cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Using Fitbits to physiologically measure Japanese English language learner speaking anxiety - a proof of concept
Creators: name: Shachter, Jonathan
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Language learning (LL) anxiety is a research area of increasing interest in the field of second language acquisition mainly due to its debilitating effects on speaking performance. Classified as a state or situational specific anxiety, automatic-emotional or cognitive worry responses related to LL anxiety can appear habitually or momentarily. LL anxiety has primarily been assessed using students’ self-reported levels of anxiety using a variety of questionnaires. However, researchers in the broader field of psychology often collect physiological responses (e.g., heart rate) in addition to self-reports. To date, tracking a language learner's heart rate (HR) changes and correlating these changes with a self-report measure in a classroom context, has been impractical both due to the cost and obtrusive nature of laboratory equipment. For this reason, an original research tool (The Fitbit Data Collection System (FDCS)) was designed and created to unobtrusively track student HR changes via Fitbit™ "smart watches". The aim of this proof-of-concept data collection was to test the efficacy of the FDCS as a tool to examine the relationship between momentary state-assessments related to LL anxiety and HR response. Participants in this study were undergraduate Japanese language students (5 males and 5 females, mean age = 19.7 years, SD = .95) at a private university in Japan. Over a period of three sessions, students wore Fitbit smart watches and performed a class-observed dialog while seated at their desks. Students were also asked how they were feeling at three intervals within each session: class start, preperformance, and post-performance. The main finding of this study is that the self-reported feelings of distress and embarrassment had a significant relationship with HR response. The FDCS was also found to be an effective tool to collect HR responses in a classroom. Tracking HR response in a classroom may further understanding of how individuals may be feeling during the course of a lesson, lecture, or performance.
Failure of the Weierstrass Preparation Theorem in quasi-analytic Denjoy-Carleman rings
Creators: name: Acquistapace, Francesca
name: Broglia, Fabrizio
name: Bronshtein, Michail
name: Nicoara, Andreea
name: Zobin, Nahum
Publisher: name: arXiv
Year: 2012
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 26E10, 32B05 (Primary), 46E25 (Secondary)

description: It is shown that Denjoy-Carleman quasi-analytic rings of germs of functions in two or more variables fail to satisfy the Weierstrass Preparation Theorem. The result is proven via a non-extension theorem.
description: 17 pages; accepted at the Advances in Mathematics
Nursing interventions of critically ill patient for stress-related hyperglycemia：A scoping review
Creators: name: Huang, Miao
name: Yang, Ruiqi
name: Pang, Dong
name: Gan, Xiuni
Publisher: name: figshare
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: ObjectiveTo map the current status of nursing interventions in critically ill patient for stress-related hyperglycemia，this review also seeks to identify the problems in the management of critical-ill with hyperglycemia.IntroductionThe raising of blood sugar is a common symptom in severe illness in adult patients, it can occur in patients with diabetes mellitus or in patients who are not diabetics. Stress-related Hyperglycemia（SHG） has been associated with increased morbidity and mortality in intensive care unit. But it’s still have contradictions in the management of SHG. Effective interventions on SHG in severe patients can improve avoiding perioperative complications and thus decrease the risk of mortality. Here we outline a scoping review that will systematically map the current status of nursing interventions or managements of SHG in critically ill.Methods and analysisOur research will follow the methodological framework for scoping reviews originally described by Arksey and O’Malley. The following databases will be searched: China National Knowledge Infrastructure（CNKI）,Wan Fang database, Vip-database, Pubmed, CINAHL, Embase, Web of science, CENTRAL, Best practice, Database of Abstracts of Reviews of Effectiveness (DARE), PsycINFO, Open Grey. Studies will be limited to those published in Chinese or English in recent 5 years. This scoping review will consider any studies including ICU patients with SHG that received any nursing interventions. Two independent review authors will screen all abstracts and titles, and full-text publications during a second stage. Next, they will extract data from each included study using a data extraction form informed by the aim of the study, a third researcher will be consulted. The results will be presented in tabular form, accompanied by a narrative summary related to the objectives of the scoping review.
title: Μελέτη για την δυνατότητα ανάκτησης του λιγνίτη με βαρυτομετρική ανάλυση
Creators: name: Μαργετης Στυλιανος
Publisher: name: Technical University of Crete
Year: 2014

description: H εργασία είχε σκοπό την ανάκτηση του εναπομένοντος λιγνίτη από την υγρή τέφρα, η οποία παράγεται από την καύση του λιγνίτη στους λέβητες των ατμοηλεκτρικών σταθμών της Δ.Ε.Η. Για τη μελέτη αυτή χρησιμοποιήθηκε η μέθοδος εμπλουτισμού της βαρυτομετρικής ανάλυσης. Το θετικό αποτέλεσμα της μελέτης επιτρέπει την παραγωγή καυσίμου με μικρή περιεκτικότητα σε τέφρα, αλλά και σταθερή ποιότητα, με αποτέλεσμα το προϊόν αυτό να μπορεί να συντελέσει στην αύξηση των διαθέσιμων εγχώριων αποθεμάτων πηγών ενέργειας.
Η συγκεκριμένη μέθοδος βασίστηκε στο διαχωρισμό του λιγνίτη από την υγρή τέφρα, με βάση τα διαφορετικά τους ειδικά βάρη, με τη βοήθεια μιας σειράς βαρέων υγρών, με προοδευτικά αυξανόμενη πυκνότητα. Με αυτόν τον τρόπο, το αρχικό δείγμα διαχωρίστηκε σε κλάσματα βάρους που αντιστοιχούσαν σε διαφορετικά ειδικά βάρη. Τα κλάσματα αυτά ζυγίστηκαν και αναλύθηκαν. Τα αποτελέσματα των ζυγίσεων και αναλύσεων εκφράστηκαν σε εκατοστιαία βάση και στη συνέχεια κατασκευάστηκαν οι καμπύλες εμπλουτισιμότητας. Έτσι είχαμε την εξαγωγή συμπερασμάτων, τόσο για τις δυνατότητες εμπλουτισμού, όσο και για την ανάκτηση του λιγνίτη.
Η εφαρμογή του βαρυτομετρικού διαχωρισμού για την ανάκτηση του λιγνίτη από την υγρή τέφρα φάνηκε ότι είναι δυνατή, γιατί το προϊόν εμπλουτίσματος που προέκυψε είχε σχετικά χαμηλή περιεκτικότητα σε τέφρα. Λαμβάνοντας υπόψη τη χαμηλή περιεκτικότητα σε τέφρα, πτητικά συστατικά, αλλά και τη σταθερότητα των ποιοτικών χαρακτηριστικών του  εμπλουτίσματος, φάνηκε η μεγάλη σημασία που έχει η αξιοποίηση της υγρής τέφρας για την οικονομία μας, αφού ο εμπλουτισμένος λιγνίτης θα αυξήσει το βαθμό απόδοσης των εξαρτημένων από την καύση του λιγνίτη μονάδων.
title: ПЕРЕВОД МНОГОЗНАЧНОЙ ЛЕКСИКИ В ПАТОФИЗИОЛОГИИ
Creators: name: Решетникова, Полина
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Полисемия, встречающаяся в медицинских текстах, осложняет работу переводчика. Перевод научных текстов, содержащих многозначную лексику, требует особой точности. В данной статье приведены стратегии работы с многозначной лексикой, позволяющие минимизировать переводческие ошибки, а также причины возникновения полисемии в языке. Была рассмотрена статья Scleroderma: “An insight into causes, pathogenesis and treatment strategies”, на примере которой были приведены примеры распознавания и перевода многозначной лексики.
title: Ανάλυση κυκλώματος αερισμού μεταλλείου Ολυμπιάδας
Creators: name: Παπαδοπουλος Θεοδωρος
Publisher: name: Technical University of Crete
Year: 2014

description: Η παρούσα διπλωματική εργασία αναφέρεται στην προσομοίωση του δικτύου αερισμού του μεταλλείου μικτών θειούχων της Ολυμπιάδας στη Χαλκιδική.
Καταρχήν παρουσιάζονται και περιγράφονται τα χαρακτηριστικά του υφιστάμενου δικτύου. Στην συνέχεια παρουσιάζεται το ισοδύναμο προσομοίωμα του υφιστάμενου δικτύου το οποίο κατασκευάστηκε. Ακολουθεί η βαθμονόμηση του μοντέλου αερισμού η οποία έγινε με δύο διαφορετικούς τρόπους. Με την πρώτη προσέγγιση, η βαθμονόμηση έγινε με σταθερές τιμές παροχής στα σημεία εισόδου και εξόδου του αέρα, ενώ η επίλυση στο δεύτερο μοντέλο έγινε με την εισαγωγή τεσσάρων ανεμιστήρων ανά δύο συνδεδεμένων παράλληλα στη βάση και στη έξοδο του φιρέ αερισμού του μεταλλείου. Στη συνέχεια συγκρίνονται τα αποτελέσματα που λαμβάνονται από την προσομοίωση του δικτύου με μετρήσεις παροχής σε διάφορα σημεία του υπόγειου δικτύου.
Από την σύγκριση των μετρήσεων και των υπολογιζόμενων ποσοτήτων προκύπτει η ανάγκη ελέγχου των μετρήσεων σε ορισμένα σημεία. Επίσης, εντοπίζονται τα βραχυκυκλώματα του δικτύου αερισμού, τα οποία οφείλονται σε διαρροές κατά μήκος αυτού, καθώς και οι δυνατότητες αερισμού των διαφόρων σημείων του μεταλλείου.
Investigation of the cryogenic deformation behaviour and subsequent recrystallization in magnesium alloy AZ31
Creators: name: Zhang, Kai
Publisher: name: Imperial College London
Year: 2021

description: Magnesium alloys attract great interest from industry and academia, as they are the lightest structural metals, which can be applied to achieve a weight reduction of car bodies to reduce energy consumption and air pollution. However, their ductility and strength are generally poor at room temperature, mainly because of their coarse grains and strong texture. This study aims to develop a novel method to refine grains and weaken the texture in magnesium (Mg) alloy AZ31, and investigate its underlying deformation and recrystallization mechanisms. This can contribute to improving the applications of Mg alloys. For this purpose, the hot deformation with pre-deformation at cryogenic temperature (CT) and room temperature (RT) was conducted and compared to the direct-hot-deformed Mg alloy. Recrystallization mainly occurred near deformation bands in RT-hot-deformed and direct-hot-deformed samples, while active recrystallization occurred near twin-twin interactions in the CT-hot-deformed sample. This resulted in finer grains and a weaker texture in the CT-hot-deformed sample, and its ductility and strength improved significantly. The pre-deformation behaviour at CT and RT was investigated with a quasi-in-situ Electron Backscatter Diffraction (EBSD). More twin-twin interactions were observed at CT than RT, which contributed to forming a weaker texture and finer twins, and higher hardening rates at CT. To further investigate how twinning and deformation bands evolve, rolling tests at CT and RT were conducted. With increasing strain, abundant deformation bands, evolving from {101 ̅1}-{101 ̅2} double twins, were observed in RT-rolled samples, while abundant twins, starting from {101 ̅2} tension twins to twin-twin interactions and twinning sequence, were observed in CT-rolled samples. During the subsequent annealing process, recrystallization occurred around deformation bands in the annealed RT-rolled sample, resulting in a strong basal texture. However, recrystallization occurred around twin-twin interactions in the annealed CT-rolled sample, forming the weak texture and fine grains.
Additional file 1 of SUFI: an automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and post-mortem human brain tissues
Creators: name: Sadashivaiah, Vijay
name: Tippani, Madhavi
name: Page, Stephanie C.
name: Kwon, Sang Ho
name: Bach, Svitlana V.
name: Bharadwaj, Rahul A.
name: Hyde, Thomas M.
name: Kleinman, Joel E.
name: Jaffe, Andrew E.
name: Maynard, Kristen R.
Publisher: name: figshare
Year: 2023
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Figure S1. Extracted spectral signatures (fingerprints) from single positive vs. multiplex lambda stacks. Comparison of spectral signatures extracted from single positives vs. a multiplex lambda stack using the Vector Component Analysis (VCA). In each subplot, normalized pixel intensity is plotted against wavelength. (i) solid lines represent the fingerprints extracted using single positives. (ii) dotted lines represent fingerprints extracted from a multiplex lambda stack. The color corresponds to peak wavelength for DAPI and Opal dyes. Lipofuscin is pseudo-colored to black. Root mean squared error (RMSE) between the two lines is calculated for each set of fingerprints. Figure S2. Extracted spectral signatures (fingerprints) of immunofluorescence data from post-mortem human brain tissue sections derived from a donor with Alzheimer's disease. Spectral signatures are extracted from single positive lambda stacks using the Vector Component Analysis (VCA). In each subplot, normalized pixel intensity is plotted against wavelength. The color corresponds to peak wavelength for DAPI and Opal dyes. Lipofuscin is pseudo-colored to black.
title: ЯЗЫК ПАНДЕМИИ: COVID-НЕОЛОГИЗМЫ В НЕМЕЦКОЯЗЫЧНОМ МЕДИАДИСКУРСЕ И ИХ ПЕРЕВОД
Creators: name: Родионова, Анастасия
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Статья посвящена изучению неологизмов, появившихся на почве пандемии вируса COVID-19 и встречающихся в актуальных публикациях немецкоязычных СМИ. Рассматривается проблема классифицирования неологизмов,
выявляются словообразовательные и семантические особенности коронавирусной лексики, отображается специфика функционирования и перевода немецких ковидизмов на русский язык.
The regulatory role of the NCoR/HDAC3 complex in Alzheimer's disease pathology
Creators: name: Davis, Nicola
Publisher: name: Imperial College London
Year: 2021

description: In the brain of Alzheimer’s disease (AD) patients, accumulation of amyloid-β and tau is accompanied by synaptic and neuronal loss and chronic inflammation. Amyloid-β is generated from the processing of the amyloid precursor protein (APP), through sequential cleavage by the β-APP-cleaving enzyme (BACE1) and the γ-secretase. The BACE1 promoter contains consensus binding sites for transcription factors, including the Peroxisome Proliferator-activated receptor-γ (PPAR- γ). PPAR- γ is a nuclear receptor, which upon ligand activation can regulate the transcription of target genes. Therefore, manipulation of PPAR-γ activity may present a potential avenue for targeting AD pathology. Nuclear receptor co-repressor 1 (NCoR) is a co-repressor of PPAR-γ, amongst other transcription factors, and exerts its repressive function by working with histone deacetylase 3 (HDAC3). We hypothesised that NCoR drives production of amyloid-β in AD through PPAR-γ modulation and our aim was to investigate the mechanisms whereby NCoR affects amyloid-β generation and degradation in the N2a neuroblastoma cell line. In addition, we assessed whether HDAC3 inhibition resulted in the opposite effects, and also affected synaptic and inflammatory markers in an ex vivo AD model. We have shown that NCoR is enriched in neurons and certain glial cells, that its expression is increased in the hippocampus of AD patients compared with healthy controls, and that NCoR increases with age. In addition, NCoR over-expression in N2a cells resulted in increased BACE1 expression, while it led to a reduction in the levels of APP and amyloid-β. Conversely, inhibition of HDAC3, using a specific inhibitor, resulted in elevations of APP and amyloid-β levels. Furthermore, HDAC3 inhibition in organotypic brain cultures of 5xFAD mice increased APP expression, lowered glial activation and rescued spine density, without altering amyloid-β levels. These data suggest that NCoR and HDAC3 play multi-faceted roles in the modulation of AD pathology, most prominently on the expression of APP, and that targeting the NCoR/HDAC3 complex could be a promising therapeutic strategy for AD.
title: МУЗЕЙ В СИСТЕМЕ КОММУНИКАЦИИ МОЛОДЕЖНОЙ АУДИТОРИИ: ФОРМАТЫ, ТЕНДЕНЦИИ, ПЕРСПЕКТИВЫ
Creators: name: Рыжкова, Ольга
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье рассмотрены особенности коммуникации музея, молодежной аудитории и цифровых СМИ. Потребность респондентов в медийном освещении музейных событий, заинтересованность в культурном досуге и преимущественные каналы информации были выявлены путем анкетирования аудитории в возрасте 18–22 лет.
title: Συγκριτική αξιολόγηση κριτηρίων αστοχίας βραχομάζας
Creators: name: Καραγιαννης Δημητριος
Publisher: name: Technical University of Crete
Year: 2014

description: Τις τελευταίες δεκαετίες παρουσιάστηκαν αρκετά κριτήρια αστοχίας για την περιγραφή της αντοχής της βραχομάζας. Τα κριτήρια αυτά στηρίζονται κυρίως σε εργαστηριακές μελέτες βραχομηχανικής, αλλά συχνά καθιστούν περίπλοκο το πρόβλημα υπολογισμού της αντοχής πετρωμάτων αντί να το επιλύσουν πρακτικά. Στο κεφάλαιο 1 της διπλωματικής εργασίας παρατίθενται ιστορικά στοιχεία, οι εξισώσεις και οι γραφικές παραστάσεις που περιγράφουν τα πρώτα κριτήρια αστοχίας που υιοθετήθηκαν στη βραχομηχανική: Mohr – Coulomb, von Mises, Tresca, Drucker – Prager, Hoek – Brown και Θεωρία Griffith.

Το κρίσιμο ερώτημα είναι ποιο από τα διαθέσιμα κριτήρια αστοχίας περιγράφει καλύτερα τη συμπεριφορά του έκαστου συγκεκριμένου πετρώματος. Στο κεφάλαιο 2 γίνεται προσπάθεια συνόψισης της μεθοδολογίας σύγκρισης κριτηρίων, όπως αυτή απορρέει από τη βιβλιογραφία, δηλαδή τις υπάρχουσες συγκριτικές μελέτες κριτηρίων αστοχίας που διερευνούν την εφαρμοσιμότητα κάποιων από τα γνωστά κριτήρια αστοχίας στον υπολογισμό μεγεθών ποικιλίας πετρωμάτων για τα οποία είναι διαθέσιμες πειραματικές τιμές πολυαξονικών δοκιμών.  Επίσης παρατίθεται ο τρόπος εφαρμογής μίας μαθηματικής μεθόδου για τον προσδιορισμό των τιμών των παραμέτρων δώδεκα κριτηρίων: Mohr-Coulomb, Hoek – Brown, Pan – Hudson, Zhang – Zhu, Drucker – Prager, Simplified Priest, Modified Wiebols – Cook, Murrel, Παραβολοειδές εκ περιστροφής (Theocaris) και Τροποποιημένο Παραβολοειδές εκ περιστροφής, καθώς και Mogi 1967 και Mogi 1971. Στο τέλος του 2ου κεφαλαίου αναφέρονται ενδεικτικά κάποιες χαρακτηριστικές μελέτες που εστιάζουν σε συγκεκριμένες πτυχές του ζητήματος.

Στο 3ο κεφάλαιο επιχειρείται αρχικά η στατιστική σύγκριση των κριτηρίων που αναλύονται στο 2ο κεφάλαιο με αποτελέσματα πολυαξονικών δοκιμών. Πιο συγκεκριμένα συγκρίνονται η μέση τυπική απόκλιση μεταξύ της υπολογισμένης τάσης αστοχίας και της αντίστοιχης πειραματικής τιμής. Επίσης λαμβάνεται υπόψη η απόκλιση υπολογισμένης-πειραματικής αντοχής σε μονοαξονική θλίψη. Το κεφάλαιο ολοκληρώνει η ποιοτική σύγκριση των κριτηρίων βάσει των διαγραμμάτων ( ,  ) για τις διάφορες τιμές  . Επίσης γίνεται αναφορά στο κριτήριο Modified Lade.

Στο 4ο κεφάλαιο παρατίθενται τα συμπεράσματα της παρούσας διπλωματικής εργασίας. Το ερώτημα στο οποίο επιχείρησε να απαντήσει μέσα από τη βιβλιογραφική έρευνα δεν απαντήθηκε θετικά: δεν υπάρχει πρόταση στις συγκεκριμένες συγκριτικές μελέτες για το ποιο είναι το βέλτιστο κριτήριο αστοχίας ανά πέτρωμα. Το κριτήριο Mohr – Coulomb 240 χρόνια μετά παραμένει επίκαιρο. Η εύκολα κατανοητή φυσική σημασία του το καθιστά ακόμη πρακτικό εργαλείο. Επίσης διαδεδομένο είναι το κριτήριο Hoek – Brown. Είναι εύκολα εφαρμόσιμο, γιατί στηρίζεται σε εύκολες εργαστηριακές δοκιμές κι όχι σε πολύπλοκες και πολυδάπανες πολυαξονικές δοκιμές. Επίσης, έχει εύκολα προσδιορίσιμες παραμέτρους και μέσα σε σχεδόν 35 χρόνια έχει γνωρίσει πολλές επεκτάσεις και προσθήκες. Κάποια από τα πιο πρόσφατα κριτήρια εχουν εξίσου καλά αποτελέσματα.
The formation of Er-oxide nanoclusters in SiO$_2$ thin films with excess Si
Creators: name: Thøgersen, Annett
name: Mayandi, Jeyanthinath
name: Finstad, Terje
name: Olsen, Arne
name: Diplas, Spyros
name: Mitome, Masanori
name: Bando, Yoshio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The nucleation, distribution and composition of erbium embedded in a SiO$_2$-Si layer were studied with High Resolution Transmission Electron Microscopy (HRTEM), Electron Energy Loss Spectroscopy (EELS), Energy Filtered TEM (EFTEM), Scanning Transmission Electron Microscopy (STEM) and X-ray Photoelectron Spectroscopy (XPS). When the SiO$_2$ layer contains small amounts of Si and Er, nanoclusters of Er-oxide are formed throughout the whole layer. Exposure of the oxide to an electron beam with 1.56*10$^6$ electrons/nm$^2$/sec. causes nanocluster growth. Initially this growth matches the Ostwald ripening model, but eventually it stagnates at a constant nanocluster radius of 2.39 nm.
title: ЯЗЫКОВОЕ ЯВЛЕНИЕ «DENGLISCH» И ЕГО ПЕРЕВОД
Creators: name: Сахно, Карина
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье рассматривается понятие, причины и типологизация такого языкового явления как «Denglisch», а также способы его перевода. «Denglisch» неоднороден. Некоторые лексические единицы в его составе имеют синонимы в
классическом немецком языке, другие – являются псевдоанглицизмами. При переводе важно понимать, когда и где стоит использовать те или иные эквивалентные соответствия.
Expression levels of blood microRNAs as biomarker of cognitive decline due to Alzheimer's disease
Creators: name: Sadlon, Angélique
Publisher: name: Imperial College London
Year: 2021

description: Studies investigating differential miRNAs expression levels in patients with Alzheimer’s disease (AD) abounded in the last decades and catalysed the interest towards miRNAs as novel non-invasive biomarkers of AD. Chapter 1 provides an overview of AD’s pathogenesis, discusses the evolution of the disease’s definition, and introduces miRNAs. In Chapter 2, a systematic review and a P-value based meta-analysis of 107 studies investigate miRNA expression levels in AD patients. This leads to a prioritisation of 25, 32 and 5 dysregulated miRNAs at study-wide significance in the brain, the blood and the cerebrospinal fluid (CSF) of AD patients, respectively. A pathway enrichment analysis for the top dysregulated miRNAs in the brain confirms their role in regulating biological functions implicated in AD. In Chapter 3, expression levels of the 32 dysregulated miRNAs in the blood and 6 top dysregulated miRNAs in the brain of AD patients, are assessed using real-time quantitative polymerase chain reaction in the blood of cognitively healthy individuals from the CHARIOT-PRO cohort. Low performers on the total Repeatable Battery for the Assessment of Neuropsychological Status scale show downregulation of six miRNAs (hsa-miR-128-3p, hsa-miR-144-5p, hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR-29c-3p and hsa-miR-363-3p). Pathway enrichment analysis highlights involvement in pathways initiating early pathogenetic changes in AD. Finally, in chapter 4, whole-genome sequencing data from the Alzheimer’s Disease Neuroimaging Initiative is used to perform an association analysis between polymorphisms within the six miRNAs’ genes and CSF biomarkers of neurodegeneration. A functional annotation of significant variants highlights expression quantitative trait loci, location in enhancer regions and alterations in the binding sites of transcription factors regulating neuronal function. The association of variants located within the same miRNA gene with different markers of neurodegeneration reveals a positive correlation between members of the amyloid cascade and microglial activation in the CSF. The final chapter highlights the clinical relevance of these findings and discusses future perspectives.
The Hamiltonian structure and Euler-Poincaré formulation of the Vlasov-Maxwell and gyrokinetic systems
Creators: name: Squire, J.
name: Qin, H.
name: Tang, W. M.
name: Chandre, C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present a new variational principle for the gyrokinetic system, similar to the Maxwell-Vlasov action presented in Ref. 1. The variational principle is in the Eulerian frame and based on constrained variations of the phase space fluid velocity and particle distribution function. Using a Legendre transform, we explicitly derive the field theoretic Hamiltonian structure of the system. This is carried out with a modified Dirac theory of constraints, which is used to construct meaningful brackets from those obtained directly from Euler-Poincaré theory. Possible applications of these formulations include continuum geometric integration techniques, large-eddy simulation models and Casimir type stability methods. [1] H. Cendra et. al., Journal of Mathematical Physics 39, 3138 (1998)
description: 36 pages, 1 figure
title: ПРАГМАТИКА ПЕРЕВОДА ИСТОРИЧЕСКИХ РЕАЛИЙ В КИНОФИЛЬМАХ
Creators: name: Семёнова, Валерия
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Данная статья посвящена вопросу перевода исторических реалий в кинофильмах. Анализ трёх вариантов киноперевода, таких как субтитры, дубляж и закадровая озвучка, выявил сложности при передаче исторических реалий, обусловленные их спецификой и особенностями киноперевода. Наиболее частотными трансформациями во всех вариантах перевода являются транскрипция, калька, контекстуальный перевод и родовидовая замена. Особое внимание уделено необходимости сохранения в переводе коммуникативно-прагматического эффекта. Именно коммуникативно-прагматический подход, который объединяет всю
совокупность вербальных и невербальных средств, помогает переводчику сохранить прагматический потенциал оригинала и должным образом передать интенции реципиентам другой языковой культуры.
Co-infections with gastrointestinal parasites in a free-range swine farm from the Transylvania area
Creators: name: Băieş, Mihai-Horia
Publisher: name: Zenodo
Year: 2021

description: Parasitic diseases cause significant economic losses in swine by diminishing productions, diseases and mortality. In the last decade, an increase in the number of free-range swine farms was noticed in Romania, further complicating the epidemiology of parasitic diseases.  The current study aimed to identify the parasitic profile of swine raised on a free-range farm from the Transylvania area. Sixty faecal samples collected from piglets, fattening pigs, and sows were investigated by flotation (Willis and McMaster), active sedimentation, Ziehl-Neelsen stain modified by Henricksen, and modified Blagg methods. The coproparasitological examination revealed parasitic infections with Balantidium coli, Eimeria spp./Isospora suis, Ascaris suum and Trichocephalus suis. The number of oocysts (OPG), cysts (CPG) and eggs (EPG) were counted per gram of faeces. Prevalence (P) and the average intensity (I) of infection varied according to age and category of investigated swine. During the spring season, the broadest spectrum of parasites was identified in fattening pigs: B. coli (P = 40%, I = 300 CPG), Eimeria spp./I. suis (P = 90%, I = 700 OPG), A. suum (P = 70%, I = 200 EPG) and T. suis (P = 60%, I = 800 EPG). Similar infection rates were observed in piglets: B. coli (P = 40%, I = 400 CPG) and Eimeria spp./I. suis (P = 90%, I = 1.000 OPG), and sows: B. coli (P = 30%, I = 200 CPG) and Eimeria spp./I. suis (P = 90%, I = 9.100 OPG). In the autumn season, the highest number of parasite species was identified in fattening pigs: B. coli (P= 40%, I=50 CPG), Eimeria spp./I. suis (P=100%, I=1700 OPG), A. suum (P=100%, I= 5940 EPG), and T. suis (P=20%, I= 225 EPG), followed by sows: B. coli (P= 90%, I= 400), Eimeria spp./I. suis (P= 30%, I= 467 OPG), and A. suum (P=60%, I=533 EPG) and piglets: B. coli (P=20%, I=225 CPG) and Eimeria spp./I. suis (P=100%, I= 31.480 OPG). Furthermore, the study showed statistical significance between seasons and age groups for all diagnosed parasites.  However, further research is required to understand better the epidemiology of these infections in swine from Transylvania.
Simultaneous exoplanet detection and instrument aberration retrieval in multispectral coronagraphic imaging
Creators: name: Ygouf, Marie
name: Mugnier, Laurent M.
name: Mouillet, David
name: Fusco, Thierry
name: Beuzit, Jean-Luc
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: High-contrast imaging for the detection and characterization of exoplanets relies on the instrument's capability to block out the light of the host star. Some current post-processing methods for calibrating out the residual speckles use information redundancy offered by multispectral imaging but do not use any prior information on the origin of these speckles. We investigate whether additional information on the system and image formation process can be used to more finely exploit the multispectral information. We developed an inversion method in a Bayesian framework that is based on an analytical imaging model to estimate both the speckles and the object map. The model links the instrumental aberrations to the speckle pattern in the image focal plane, distinguishing between aberrations upstream and downstream of the coronagraph. We propose and validate several numerical techniques to handle the difficult minimization problems of phase retrieval and achieve a contrast of 10^6 at 0.2 arcsec from simulated images, in the presence of photon noise. This opens up the the possibility of tests on real data where the ultimate performance may override the current techniques if the instrument has good and stable coronagraphic imaging quality. This paves the way for new astrophysical exploitations or even new designs for future instruments.
Controlling charge injection and balance in solution-processed organic optoelectronic devices
Creators: name: Yan, Hao
Publisher: name: Imperial College London
Year: 2021

description: Solution-processed optoelectronic devices, including organic light-emitting diodes (OLEDs) and organic photodetectors (OPDs), have the promising potential to produce low-cost, flexible, and large-area functional devices via printing technologies. To achieve efficient and stable devices with low driving voltages in OLEDs, hole/electron injection and transport, as well as balanced hole/electron carriers, are important parameters. This thesis presents several efficient approaches to enhance charge injection and balance by either doping or inserting interlayers and explores the origin of charge injection mechanisms. Firstly, hole injection improvement by electrochemical doping process is discussed. An electrochemical doping process (p-type doping) is proved to strongly reduce hole injection barrier, enhance hole injection and mobility, thereby lowering OLED turn-on voltages with reduced efficiency roll-off. Secondly, controlling dipole strength and energetics of conjugated polyelectrolytes as electron injection layers in OLEDs has achieved more balanced charge carrier density and hole blocking property with improved device efficiency, which gives a new synthesis route for developing highly efficient CPE injection materials. Thirdly, controlling dark current and response time of OPD via non-fullerene acceptor (NFAs) is discussed. The nano-scale aggregated morphology of trap-free NFA blends can not only maintain charge generation, but also improve charge mobility to reduce the response time of OPDs. Finally, dynamic molecular conformation-controlled energy transfer from locally excited states to either charge transfer state (CT) or β phase in light-emitting polymers is discussed. The formation of the β-phase was a dynamic and reversible process. Spontaneous and reversible CT on-off emission with temperature dependence was observed due to dynamic molecular conformation activated by thermal energy to align transition dipole and enhance energy transfer from glassy to CT. Overall, these findings of this thesis provide important insights into the mechanism of charge carrier injection and balance in organic optoelectronic devices that can guide for improving device performance.
Dynamic Sunk Costs: Importance matters when opportunity costs are explicit.
Creators: name: Harman, Jason
name: Gonzalez-Valejjo, Claudia
name: Vancouver, Jeffrey
Publisher: name: Journal of Dynamic Decision Making
Year: 2021

description: The sunk cost fallacy is a well-established phenomenon where decision makers continue to commit resources, or escalate commitment, because of previously committed efforts, even when they have knowledge that their returns will not outweigh their investment. Most research on the sunk cost fallacy is done using hypothetical scenarios where participants make a single decision to continue with a project or to abandon it. This paradigm has several limitations and has resulted in a relatively limited understanding sunk cost behavior. To address some of these limitations, we created a dynamic repeated choice paradigm where sunk costs are learned over time and opportunity costs are explicit. Over three experiments we show that the sunk cost fallacy depends on the relative a priori importance of the goal being invested in. We observed escalation of commitment only when the sunk cost domain is more important than alternatives (explicit opportunity costs), and participants showed de-escalation of commitment to the sunk costs domain otherwise.
description: Journal of Dynamic Decision Making, Vol 6 (2020)
Qualitative Face of Big Data
Creators: name: Wendt, Alexander Nicolai
Publisher: name: Journal of Dynamic Decision Making
Year: 2020

description: The technological possibilities for new data sources in media psychology, such as online live recordings, called Live Streaming, are growing continuously. These sources do not only offer plentiful quantitative material but also a fairly new access to ecologically valid and unobtrusive observation of problem-solving and decision-making processes. However, to exploit these potentials, epistemological and methodological reflection should guide research. The availability of Big Data and naturally occurring data sets (NODS) allows to revise the historical controversies on the eligibility of self-description. Drawing on such reflections, media psychology can contribute to renovate well established research methods, such as think aloud protocols, in order to enhance their empirical claims. Apart from other confident attempts to improve these methods, phenomenology and ethnomethodology offer a fruitful account to develop innovative data sources for self-description. Yet, this approach does not support a recurrence of self-description’s previous application but proposes an epistemological shift towards more subtle observations. In order to convey the potentials of media psychology, the risk of repeating classical mistakes, such as introspectionism, have to be regarded. Beyond these fallacies, however, modern digital technology holds encouraging potentials which have already partly been sighted by video gaming research. Due to the similarity of digital environments to laboratory setups, there remains to be a continuity from offline to online research, from traditional data to Big Data. Nevertheless, a true advance into new possibilities requires understanding the qualitative meaning of such data.
description: Journal of Dynamic Decision Making, Vol 6 (2020)
title: ПРОБЛЕМЫ ФУНКЦИОНИРОВАНИЯ ЭСТОНСКИХ ШКОЛ В НОВГОРОДСКОЙ ГУБЕРНИИ В 1918–1927 гг.
Creators: name: Соколов, Павел
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В данной статье рассматриваются основные проблемы реализации советской образовательной политики в эстонских колониях Новгородской губернии в первое послереволюционное десятилетие. Конец 1910-х – начало 1920-х гг. характеризуется стихийным открытием национальных школ в рамках новой национальной политики, многие из которых не имели необходимого для функционирования материального и кадрового обеспечения. Для эстонских школ Новгородской губернии были характерны малокомплектность, повышенная площадь
районов обслуживания, слабая посещаемость, короткий учебный год, снижавшие эффективность их работы. После 1922 г. количество эстонских школ в губернии стабилизировалось, наметилась тенденция к улучшению их материального положения.
Additional file 1 of Physical activity and psychological adjustment among retirees: a systematic review
Creators: name: Sharifi, Mehdi
name: Nodehi, Davud
name: Bazgir, Behzad
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Medical complications in Australian children with achondroplasia
Creators: name: Armstrong, Jennifer
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis builds on the currently available literature on medical complications in achondroplasia, the most common skeletal dysplasia causing short stature in humans. Studies have reported the rates of medical investigations, complications, interventions, and service utilisation in achondroplasia. Limitations have been uncertain diagnosis, clarity of follow up, variable quality medical records, and reliance on self-reports therefore recall. Management of medical complications has evolved over time in line with American Academy of Pediatrics Guidelines, and there is a need for contemporary accounts of medical complications. Pharmaceutical therapies for achondroplasia are emerging, and this natural history data will assist in the evaluation of these. A retrospective cohort study of 108 participants was undertaken to address identified gaps in the literature. Rates of craniocervical stenosis, hydrocephalus, hearing impairment, sleep disordered breathing, lower limb malalignment, thoracolumbar kyphosis, symptomatic spinal stenosis, obesity, respiratory illness, and death were recorded. There was variability in the rates of complications in this cohort, compared with previous reports related to differences in population demographics, local practices, and changes in management over time. Recommendations for improving clinical practice include improved record keeping, incorporating new evidence into practice, improving the clinical management of some conditions, and improving data collection for rare and less studied complications. Recommendations for future research include the standardisation of prospective data collection across multiple sites, evaluation of medical complications in children treated with pharmaceutical therapists, and to better understand phenotypical differences in achondroplasia.
Regression modelling of conditional morphogene expression links and quantifies the impact of growth rate, fitness and macromorphology with protein secretion in Aspergillus niger
Creators: name: Cairns, Timothy C.
name: De Kanter, Tom
name: Zheng, Xiaomei Z.
name: Zheng, Ping
name: Sun, Jibin
name: Meyer, Vera
Publisher: name: Springer Science and Business Media LLC
Year: 2023
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
subject: Aspergillus niger
subject: macromorphology
subject: pellet
subject: cell wall
subject: chitin
subject: growth rate
subject: total protein
subject: tet-on
subject: genome editing
subject: dlpA
subject: crzA

description: Background: Filamentous fungi are used as industrial cell factories to produce a diverse portfolio of proteins, organic acids, and secondary metabolites in submerged fermentation. Generating optimized strains for maximum product titres relies on a complex interplay of molecular, cellular, morphological, and macromorphological factors that are not yet fully understood. Results: In this study, we generate six conditional expression mutants in the protein producing ascomycete Aspergillus niger and use them as tools to reverse engineer factors which impact total secreted protein during submerged growth. By harnessing gene coexpression network data, we bioinformatically predicted six morphology and productivity associated ‘morphogenes’, and placed them under control of a conditional Tet-on gene switch using CRISPR-Cas genome editing. Strains were phenotypically screened on solid and liquid media following titration of morphogene expression, generating quantitative measurements of growth rate, filamentous morphology, response to various abiotic perturbations, Euclidean parameters of submerged macromorphologies, and total secreted protein. These data were built into a multiple linear regression model, which identified radial growth rate and fitness under heat stress as positively correlated with protein titres. In contrast, diameter of submerged pellets and cell wall integrity were negatively associated with productivity. Remarkably, our model predicts over 60% of variation in A. niger secreted protein titres is dependent on these four variables, suggesting that they play crucial roles in productivity and are high priority processes to be targeted in future engineering programs. Additionally, this study suggests A. niger dlpA and crzA genes are promising new leads for enhancing protein titres during fermentation. Conclusions: Taken together this study has identified several potential genetic leads for maximizing protein titres, delivered a suite of chassis strains with user controllable macromorphologies during pilot fermentation studies, and has quantified four crucial factors which impact secreted protein titres in A. niger.
EIT-control of single-atom motion in an optical cavity
Creators: name: Kampschulte, Tobias
name: Alt, Wolfgang
name: Manz, Sebastian
name: Martinez-Dorantes, Miguel
name: Reimann, René
name: Yoon, Seokchan
name: Meschede, Dieter
name: Bienert, Marc
name: Morigi, Giovanna
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We demonstrate cooling of the motion of a single atom confined by a dipole trap inside a high-finesse optical resonator. Cooling of the vibrational motion results from EIT-like interference in an atomic Λ-type configuration, where one transition is strongly coupled to the cavity mode and the other is driven by an external control laser. Good qualitative agreement with the theoretical predictions is found for the explored parameter ranges. The role of the cavity in the cooling dynamics is confirmed by means of a direct comparison with EIT-cooling performed in the dipole trap in free space. These results set the basis to the realization of an efficient photonic interface based on single atoms.
Poster: Ensemble Learning for Industrial Intrusion Detection
Creators: name: Kus, Dominik Adam
name: Wolsing, Konrad
name: Pennekamp, Jan
name: Wagner, Eric
name: Henze, Martin
name: Wehrle, Klaus
Publisher: name: RWTH Aachen University
Year: 2022

description: 38. Annual Computer Security Applications Conference, ACSAC ’22, Austin, TX, USA, 5 Dec 2022 - 9 Dec 2022
title: Υλοποίηση αλγορίθμου μοριακής δυναμικής (molecular dynamics) σε αναδιατασσόμενη λογική
title: Implementation of a molecular dynamics algorithm in reconfigurable logic
Creators: name: Μαλαβαζος Κωνσταντινος
Publisher: name: Technical University of Crete
Year: 2016

description: Η συνεχής ανάπτυξη της επιστήμης των υπολογιστών τα τελευταία χρόνια έχει αλλάξει ριζικά τον τρόπο προσέγγισης των επιστημονικών προβλημάτων. Οι προσομοιώσεις σε υπολογιστή έχουν εξελιχθεί ως τον τρίτο πυλώνα της επιστήμης, γεφυρώνοντας το χάσμα ανάμεσα στην παραδοσιακές δύο διαδικασίες, θεωρία και πείραμα. Ένα τέτοιο παράδειγμα αποτελούν οι προσομοιώσεις Μοριακής Δυναμικής. Η προσομοίωση Μοριακής Δυναμικής βασίζεται στον υπολογισμό διαφόρων δυνάμεων. Οι σημαντικότερες και πιο χρονοβόρες για τον υπολογισμό τους είναι οι long-ranged non-bonded forces. Στο παρελθόν έχουν γίνει διάφορες προσπάθειες επιτάχυνσης αυτού του κομματιού της προσομοίωσης.
Η παρούσα διπλωματική εργασία στοχεύει να επιταχύνει την προσομοίωση Μοριακής Δυναμικής που προσφέρει το πακέτο NAMD 2.10 με την βοήθεια της τεχνολογίας των FPGAs. Το πακέτο αυτό προσφέρει από μόνο του ποικίλους τρόπους επιτάχυνσης της διαδικασίας, όπως με την βοήθεια του CHARM++ ή και μέσω GPU χρησιμοποιώντας CUDA. Για την επίτευξη του στόχου της διπλωματικής εργασίας αυτής χρειάστηκε η μετατροπή του κώδικα από CUDA σε C και έπειτα με την βοήθεια του εργαλείου Vivado HLS 2015.4 να δημιουργηθεί κώδικας περιγραφής υλικού κατάλληλος για την εκάστοτε επιθυμητή FPGA.
Πιο συγκεκριμένα, ο πολυνηματικός κώδικας CUDA που υλοποιούσε τις δυνάμεις αυτές μετατράπηκε σε ένα μονονηματικό κώδικα C ώστε το εργαλείο Vivado HLS να τον δεχτεί. Έπειτα στο Vivado HLS 2015.4 υλοποιήθηκαν μια σειρά από διαφορετικές σχεδιάσεις πάνω σε συγκεκριμένη FPGA και χρησιμοποιήθηκαν μια σειρά από directives που παρέχει το εργαλείο και δημιουργούν βέλτιστο κώδικα περιγραφής υλικού.
Τέλος, οι σχεδιάσεις δεν κατέβηκαν ποτέ πραγματικά σε FPGA αλλά έγιναν πάρα πολλές προσομοιώσεις του κώδικα με το εργαλείο. Τα αποτελέσματα έδειξαν πως το I/O δημιουργεί ιδιαίτερα προβλήματα και χωρίς αυτό το σύστημα μπορεί να πάρει μέχρι και 6,18x speedup σε σχέση με το Software με χρήση CHARM++, που εκτελέστηκε σε ένα σύστημα με CPU Intel Core i5-4690Κ (4 cores – 4 threads) στα 3.9 GHz και 8 GB RAM και λειτουργικό σύστημα Linux Ubuntu 15.04 64bit.
Sustainability of carbon management technologies
Creators: name: Alqahtani, Amjad Saeed
Publisher: name: Imperial College London
Year: 2021

description: Carbon dioxide (CO2) is the main contributor to climate change and thereby to global warming. Several technologies have been proposed to reduce atmospheric CO2 emissions, such as CO2 capture and storage (CCS), CO2 capture and utilization (CCU) and hydrogen production. From these proposals, converting the captured CO2 into valuable products was seen as a promising area to explore. Correspondingly, CCU is achieved when the captured CO2 is utilised to produce chemicals and fuels that are more environmentally friendly than their fossil-based ones. Yet, the cost of hydrogen and the energy consumption associated are key issues to deal with. This thesis aims to understand and explain the role of hydrogen production, CCS, and CCU in the sustainability context. The first part of the study focused on the hydrogen production pathways as a crucial component in the decarbonisation of the transport, heating, and chemicals sectors. A linear optimisation model was built to explore carbon-neutral shares of all the investigated production routes in terms of their total cost that included the externalities plus the economic performance. The results supported an approach for establishing strategies for the much-needed energy transition by promoting blue (fossil-based with CCS) hydrogen at present until green hydrogen becomes competitive. The second part focused on evaluating the best use of wind energy between the CCU route to methanol from CO2 and hydrogen to be used as a fuel in the transport sector or to decarbonise the electricity mix directly considering the energy systems constraints through scenario-based modelling. It was concluded that, at present, decarbonising the electricity grid using renewable energy sources with CCS would offer greater environmental benefits, without incurring large changes indirect economic costs, compared to producing methanol from the hydrogenation of captured CO2.