cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(103073) Herbert Edward de Rougemont
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(103071) Clara Mary Monica Blundell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Celebrating 4TU.ResearchData's Role in Fostering Open Science
Creators: name: Casella, Deirdre
name: Dunning, Alastair
name: van Giessen, Femke
name: Gramsbergen, Egbert
name: Ilamparuthi, Santosh
name: Jones, Sarah
name: Plomp-Petersen, Esther
name: de Smaele, Madeleine
name: Teperek, Marta
name: Turkyilmaz-van der Velden, Yasemin
name: Verbakel, Ellen
Publisher: name: Zenodo
Year: 2020
Subjects: FAIR
Open Science
4TU.ResearchData
open science
FAIR practice
data stewardship
FAIR Data
community
EOSC
collaboration
4TUResearchData
repository
data sharing

description: Presentations and materials of the event: Celebrating 4TU.ResearchData’s Role in Fostering Open Science, which was hosted by 4TU.ResearchData on 29 September 2020.
Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents
Creators: name: Lu, Yuan
name: Schoenfisch, Mark H.
name: Slomberg, Danielle L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Secondary amine-functionalized chitosan oligosaccharides of different molecular weights (i.e., ~2500, 5000, 10000) were synthesized by grafting 2-methyl aziridine from the primary amines on chitosan oligosaccharides, followed by reaction with nitric oxide (NO) gas under basic conditions to yield N-diazeniumdiolate NO donors. The total NO storage, maximum NO flux, and half-life of the resulting NO-releasing chitosan oligosaccharides were controlled by the molar ratio of 2-methyl aziridine to primary amines (e.g., 1:1, 2:1) and the functional group surrounding the N-diazeniumdiolates (e.g., polyethylene glycol (PEG) chains), respectively. The secondary amine-modified chitosan oligosaccharides greatly increased the NO payload over existing biodegradable macromolecular NO donors. In addition, the water-solubility of the chitosan oligosaccharides enabled their penetration across the extracellular polysaccharides matrix of Pseudomonas aeruginosa biofilms and association with embedded bacteria. The effectiveness of these chitosan oligosaccharides at biofilm eradication was shown to depend on both the molecular weight and ionic characteristics. Low molecular weight and cationic chitosan oligosaccharides exhibited rapid association with bacteria throughout the entire biofilm, leading to enhanced biofilm killing. At concentrations resulting in 5-log killing of bacteria in Pseudomonas aeruginosa biofilms, the NO-releasing and control chitosan oligosaccharides elicited no significant cytotoxicity to mouse fibroblast L929 cells in vitro.
Towards Inclusive Avatars: Disability Representation in Avatar Platforms
Creators: name: Mack, Kelly
name: Hsu, Rai Ching Ling
name: Monroy-Hernández, Andrés
name: Smith, Brian A.
name: Liu, Fannie
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Digital avatars are an important part of identity representation, but there is little work on understanding how to represent disability. We interviewed 18 people with disabilities and related identities about their experiences and preferences in representing their identities with avatars. Participants generally preferred to represent their disability identity if the context felt safe and platforms supported their expression, as it was important for feeling authentically represented. They also utilized avatars in strategic ways: as a means to signal and disclose current abilities, access needs, and to raise awareness. Some participants even found avatars to be a more accessible way to communicate than alternatives. We discuss how avatars can support disability identity representation because of their easily customizable format that is not strictly tied to reality. We conclude with design recommendations for creating platforms that better support people in representing their disability and other minoritized identities.
(103068) Edmund Harrington Molyneux-Seal
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Non-Tachyonic Semi-Realistic Non-Supersymmetric Heterotic String Vacua
Creators: name: Ashfaque, Johar M.
name: Athanasopoulos, Panos
name: Faraggi, Alon E.
name: Sonmez, Hasan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The heterotic--string models in the free fermionic formulation gave rise to some of the most realistic string models to date, which possess N=1 spacetime supersymmetry. Lack of evidence for supersymmetry at the LHC instigated recent interest in non-supersymmetric heterotic-string vacua. We explore what may be learned in this context from the quasi--realistic free fermionic models. We show that constructions with a low number of families give rise to proliferation of a priori tachyon producing sectors, compared to the non--realistic examples, which typically may contain only one such sector. The reason being that in the realistic cases the internal six dimensional space is fragmented into smaller units. We present one example of a quasi--realistic, non--supersymmetric, non--tachyonic, heterotic--string vacuum and compare the structure of its massless spectrum to the corresponding supersymmetric vacuum. While in some sectors supersymmetry is broken explicitly, i.e. the bosonic and fermionic sectors produce massless and massive states, other sectors, and in particular those leading to the chiral families, continue to exhibit fermi-bose degeneracy. In these sectors the massless spectrum, as compared to the supersymmetric cases, will only differ in some local or global U(1) charges. We discuss the conditions for obtaining $n_b=n_f$ at the massless level in these models. Our example model contains an anomalous U(1) symmetry, which generates a tadpole diagram at one loop-order in string perturbation theory. We speculate that this tadpole diagram may cancel the corresponding diagram generated by the one-loop non-vanishing vacuum energy and that in this respect the supersymmetric and non-supersymmetric vacua should be regarded on equal footing. Finally we discuss vacua that contain two supersymmetry generating sectors.
description: 31 pages. 10 tables. Minor corrections. Tables are amended. Published version
(103067) Teresa Molyneux-Seal
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Electronic structure of few-layer black phosphorus from $μ$-ARPES
Creators: name: Margot, Florian
name: Lisi, Simone
name: Cucchi, Irène
name: Cappelli, Edoardo
name: Hunter, Andrew
name: Gutiérrez-Lezama, Ignacio
name: Ma, KeYuan
name: von Rohr, Fabian
name: Berthod, Christophe
name: Petocchi, Francesco
name: Poncé, Samuel
name: Marzari, Nicola
name: Gibertini, Marco
name: Tamai, Anna
name: Morpurgo, Alberto F.
name: Baumberger, Felix
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Black phosphorus (BP) stands out among two-dimensional (2D) semiconductors because of its high mobility and thickness dependent direct band gap. However, the quasiparticle band structure of ultrathin BP has remained inaccessible to experiment thus far. Here we use a recently developed laser-based micro-focus angle resolved photoemission ($μ$-ARPES) system to establish the electronic structure of 2-9 layer BP from experiment. Our measurements unveil ladders of anisotropic, quantized subbands at energies that deviate from the scaling observed in conventional semiconductor quantum wells. We quantify the anisotropy of the effective masses and determine universal tight-binding parameters which provide an accurate description of the electronic structure for all thicknesses.
description: Supporting Information available upon request
(103066) Florence Madelena Saunders
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Tetraspecific ligand for tumor-targeted delivery of nanomaterials
Creators: name: Liu, Rihe
name: Kim, Dongwook
name: Friedman, Adam D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The polygenetic nature of most cancers emphasizes the necessity of cancer therapies that target multiple essential signaling pathways. However, there is a significant paucity of targeting ligands with multi-specificities for targeted delivery of biomaterials. To address this unmet need, we generated a tetraspecific targeting ligand that recognizes four different cancer biomarkers, including VEGFR2, αvβ3 integrin, EGFR, and HER2 receptors, which have been implicated in numerous malignant tumors. The tetraspecific targeting ligand was constructed by sequentially connecting four targeting ligand subunits via flexible linkers, yielding a fusion protein that can be highly expressed in E. coli and readily purified to near homogeneity. Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI) studies and extensive cellular binding analyses indicated that all the targeting ligand subunits in the tetraspecific fusion protein recognized their target receptors proximately to the corresponding monospecific ligands. The resulting tetraspecific targeting ligand was applied for the delivery of nanomaterials such as gold nanoparticles (AuNPs) for targeted hyperthermic killing of various cancer cell lines with biomarkers of interest expressed. We demonstrate that the tetraspecific ligand can be facilely introduced on the surface of AuNPs and efficient target-dependent killing of cancer cells can be achieved only when the AuNPs are conjugated with the tetraspecific ligand. Significantly, the tetraspecific ligand simultaneously interacts with more than one receptors, such as EGFR and HER2 receptors, when they are expressed on the surface of the same cell, as demonstrated by in vitro binding assays and cell binding analyses. Our results demonstrate that the tetraspecific ligand, through multivalency and synergistic binding, can be readily used to generate various ‘smart’ biomaterials with greatly broadened tumor targeting range for simultaneous targeting of multiple signaling pathways on many different cancer types.
(103065) Jessie Adelaide Saunders
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(103064) Edith Caroline Saunders
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
[OS FAIR 2023] Monitoring Open Science in the context of rewards and incentives for Open Science
Creators: name: Malaguarnera, Giulia
Publisher: name: Zenodo
Year: 2023

description: These are the slides presented by Giulia Malaguarnera for GraspOS in the workshop on Monitoring Open Science in the context of rewards and incentives for Open Science, held at the Open Science FAIR in Madrid on 25 September 2023. 
The workshop aimed to establish the context for Open Science Policy and Research Assessment and to provide a brief overview of the importance of monitoring Open Science practices and policies, and to offer insights from the collective efforts of the OPUS, GraspOS, and PathOS projects.
Materials and analysis of the workshops conducted for inspiration process followed by teachers' study
Creators: name: Miriam, Calvera-Isabal
Publisher: name: Zenodo
Year: 2024
Subjects: citizen science
learning
learning design
inspiration

description: This dataset contains the materials and analysis of the workshops conducted with teachers to understand the inspiration process followed by teachers during the learning design process. It is part of a study by Calvera-Isabal M. (to be published). 

This work has been funded by PID2020-112584RB-C33 funded by MCIN/AEI/10.13039/501100011033, the CS Track project, EU Horizon 2020 programme [grant agreement No 872522] and H2O Learn project PID2020-112584RB-C33 funded by MCIN/ AEI / 10.13039/501100011033.
Lectura Vitae – Émergence d'un langage biologique universel à l'intérieur du génome humain
Creators: name: BOUHADJILA, MOURAD
Publisher: name: Zenodo
Year: 2025
Subjects: génome - symbolique language - Lectura Vitae - Cellular Biology - semantics - genetic code

description: Lectura Vitae – Une hypothèse symbolique pour la lecture cellulaire du génome humain.

Cette thèse propose un langage universel basé sur la symbolisation des fonctions cellulaires exprimées par les gènes. Chaque cellule devient un lecteur, chaque gène un verbe, chaque pathologie une faute de lecture. Le projet Lectura Vitae vise à relier la génétique, la sémantique et la médecine à travers une nouvelle grammaire du vivant. Cette publication est destinée à ouvrir un dialogue avec les chercheurs, médecins, enseignants et ingénieurs en IA.
Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy
Creators: name: Xu, Zhenghong
name: Wang, Yuhua
name: Miao, Lei
name: Huang, Leaf
name: Guo, Shutao
name: Lin, Ching Hsuan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The formulation of water insoluble organic compounds into nanoparticles has become a widely established method for enhancing the delivery and efficacy of cancer therapeutics. Therefore, a comparable approach when applied to water insoluble inorganic compounds should also promote similar advantages. Herein, we have successfully formulated insoluble iodinated cisplatin (CDDP-I) into a LPI NPs (lipid-coated iodinated CDDP nanoparticles). Two separate microemulsions were combined, each containing a precursor for the synthesis of CDDP-I. The resulting CDDP-I precipitate was then coated with an anionic lipid and dispersed in water with the help of an additional lipid. This method allows us to effectively encapsulate CDDP-I and was able to achieve a considerable drug loading of 82 wt%. Administered LPI NPs demonstrated high level accumulation in tumor tissues and exhibited an anti-cancer activity comparable to free CDDP in two melanoma xenograft models without inducing nephrotoxocity. The benefits offered through this delivery formulation are not unique to CDDP-I, as this versatile platform may be extended to the formulation of other inorganic compounds that are both water and oil insoluble into nanoparticles for superior anticancer efficacy.
Tunneling Plasmonics in Bilayer Graphene
Creators: name: Fei, Z.
name: Iwinski, E. G.
name: Ni, G. X.
name: Zhang, L. M.
name: Bao, W.
name: Rodin, A. S.
name: Lee, Y.
name: Wagner, M.
name: Liu, M. K.
name: Dai, S.
name: Goldflam, M. D.
name: Thiemens, M.
name: Keilmann, F.
name: Lau, C. N.
name: Castro-Neto, A. H.
name: Fogler, M. M.
name: Basov, D. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report experimental signatures of plasmonic effects due to electron tunneling between adjacent graphene layers. At sub-nanometer separation, such layers can form either a strongly coupled bilayer graphene with a Bernal stacking or a weakly coupled double-layer graphene with a random stacking order. Effects due to interlayer tunneling dominate in the former case but are negligible in the latter. We found through infrared nano-imaging that bilayer graphene supports plasmons with a higher degree of confinement compared to single- and double-layer graphene, a direct consequence of interlayer tunneling. Moreover, we were able to shut off plasmons in bilayer graphene through gating within a wide voltage range. Theoretical modeling indicates that such a plasmon-off region is directly linked to a gapped insulating state of bilayer graphene: yet another implication of interlayer tunneling. Our work uncovers essential plasmonic properties in bilayer graphene and suggests a possibility to achieve novel plasmonic functionalities in graphene few-layers.
description: 27 pages, 11 figures
LIDAR-based Stabilization, Navigation and Localization for UAVs Operating in Dark Indoor Environments
Creators: name: ik, Matěj Petrl\'
name: ik, Tom\' aš Krajn\'
name: Saska, Martin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Autonomous operation of UAVs in a closed environment requires precise and reliable pose estimate that can stabilize the UAV without using external localization systems such as GNSS. In this work, we are concerned with estimating the pose from laser scans generated by an inexpensive and lightweight LIDAR. We propose a localization system for lightweight (under 200g) LIDAR sensors with high reliability in arbitrary environments, where other methods fail. The general nature of the proposed method allows deployment in wide array of applications. Moreover, seamless transitioning between different kinds of environments is possible. The advantage of LIDAR localization is that it is robust to poor illumination, which is often challenging for camera-based solutions in dark indoor environments and in the case of the transition between indoor and outdoor environment. Our approach allows executing tasks in poorly-illuminated indoor locations such as historic buildings and warehouses, as well as in the tight outdoor environment, such as forest, where vision-based approaches fail due to large contrast of the scene, and where large well-equipped UAVs cannot be deployed due to the constrained space.
(103063) Mary Elizabeth [Bendall]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery
Creators: name: Mo, Ran
name: Gu, Zhen
name: Sun, Wujin
name: Jiang, Tianyue
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Stimuli-triggered drug delivery systems are primarily focused on the applications of the tumor microenvironmental or cellular physiological cues to enhance the release of drugs at the target site. In this study, we applied adenosine-5′-triphosphate (ATP), the primary “energy molecule”, as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level. A new ATP-responsive anticancer drug delivery strategy utilizing DNA-graphene crosslinked hybrid nanoaggregates as carriers was developed for controlled release of doxorubicin (DOX), which consists of graphene oxide (GO), two single-stranded DNA (ssDNA, denoted as DNA1 and DNA2) and ATP aptamer. The single-stranded DNA1 and DNA2 together with the ATP aptamer serve as the linkers upon hybridization for controlled assembly of the DNA-GO nanoaggregates, which effectively inhibited the release of DOX from the GO nanosheets. In the presence of ATP, the responsive formation of the ATP/ATP aptamer complex causes the dissociation of the aggregates, which promoted the release of DOX in the environment with a high ATP concentration such as cytosol compared with that in the ATP-deficient extracellular fluid. This supports the development of a novel ATP-responsive platform for targeted on-demand delivery of anticancer drugs inside specific cells.
Local and global adjustments of stimulus-based task conflict
Creators: name: Moretti, Luca
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: A prominent feature of cognitive control is that its deployment is regulated depending on the environmental circumstances. Control upregulation has been widely documented in response-conflict paradigms where congruency effects are reduced both following incongruent trials, and in blocks where incongruent trials are the majority. In two preregistered task switching experiments, we investigate whether similar flexible mechanisms are also available when dealing with stimulus-based task conflict. Building up on previous Stroop studies, task conflict was measured as the difference in performance between bivalent congruent and univalent trials, which we name the “valency effect”. If cognitive control is upregulated analogously to what observed with response conflict, valency effects should be reduced following bivalent trials and in majority-bivalent blocks. Furthermore, as cognitive control upregulation has been proposed to be task specific, we assessed whether switching to a new task eliminates the expected modulations of task conflict. The results broadly matched our predictions. First, we observed a reduction of the valency effect following bivalent trials similar to the well-known congruency sequence effect, demonstrating similar patterns of flexible control adjustment to task and response conflict. This valency sequence effect was limited to task repetitions, indicating that local control adjustments are task specific. Furthermore, task conflict was reduced in majority-bivalent blocks, similar to the proportion-congruency effect. This finding extends previous Stroop studies suggesting that control is recruited proactively when dealing with stimulus-based task conflict. The proportion-valency effect was limited to task-switch trials, leaving open the question on the precise mechanisms behind sustained control adjustments.
(103062) William Edward Bendall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On one-step replica symmetry breaking in the Edwards-Anderson spin glass model
Creators: name: Del Ferraro, Gino
name: Wang, Chuang
name: Zhou, Hai-Jun
name: Aurell, Erik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We consider a one-step replica symmetry breaking description of the Edwards-Anderson spin glass model in 2D. The ingredients of this description are a Kikuchi approximation to the free energy and a second-level statistical model built on the extremal points of the Kikuchi approximation, which are also fixed points of a Generalized Belief Propagation (GBP) scheme. We show that a generalized free energy can be constructed where these extremal points are exponentially weighted by their Kikuchi free energy and a Parisi parameter $y$, and that the Kikuchi approximation of this generalized free energy leads to second-level, one-step replica symmetry breaking (1RSB), GBP equations. We then proceed analogously to Bethe approximation case for tree-like graphs, where it has been shown that 1RSB Belief Propagation equations admit a Survey Propagation solution. We discuss when and how the one-step-replica symmetry breaking GBP equations that we obtain also allow a simpler class of solutions which can be interpreted as a class of Generalized Survey Propagation equations for the single instance graph case.
description: 34 pages, 4 figures
Highly stable aptamers selected from a 2′-fully modified fGmH RNA library for targeting biomaterials
Creators: name: Liu, Rihe
name: Kim, Dongwook
name: Friedman, Adam D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: When developed as targeting ligands for the in vivo delivery of biomaterials to biological systems, RNA aptamers immediately face numerous obstacles, in particular nuclease degradation and post-selection 2′ modification. This study aims to develop a novel class of highly stable, 2′-fully modified RNA aptamers that are ideal for the targeted delivery of biomaterials. We demonstrated the facile transcription of a fGmH (2′-F-dG, 2′-OMe-dA/dC/dU) RNA library with unexpected hydrophobicity, the direct selection of aptamers from a fGmH RNA library that bind Staphylococcus aureus Protein A (SpA) as a model target, and the superior nuclease and serum stability of these aptamers compared to 2′-partially modified RNA variants. Characterizations of fGmH RNA aptamers binding to purified SpA and to endogenous SpA present on the surface of S. aureus cells demonstrate fGmH RNA aptamer selectivity and stability. Significantly, fGmH RNA aptamers were able to functionalize, stabilize, and further deliver aggregation-prone silver nanoparticles (AgNPs) to S. aureus with SpA-dependent antimicrobial effects. This study describes a novel aptamer class with considerable potential to improve the in vivo applicability of nucleic acid-based affinity molecules to biomaterials.
Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma
Creators: name: Wang, Yuhua
name: Huo, Meirong
name: Zhao, Yan
name: Huang, Leaf
name: Xu, Zhenghong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Lipid-calcium-phosphate nanoparticle (NP) delivery of Trp2 peptide vaccine is one of the most effective vaccine strategies against melanoma. However, due to the immunosuppressive microenvironment in the tumor, the achievement of potent immune responses remains a major challenge. NP delivery systems provide an opportunity to deliver chemotherapy agent to modulate the tumor microenvironment (TME) and improve the vaccine activity. Anti-inflammatory triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is a broad spectrum inhibitor of several signaling pathways that are important in both cancer cells and cells in the TME. Intravenous delivery of CDDO-Me using poly-lactic-glycolic-acid NP combination with subcutaneous Trp2 vaccine resulted in an increase of antitumor efficacy and apoptotic tumor tissue than Trp2 vaccine alone in B16F10 melanoma. There was a significant decrease of both Treg cells and MDSCs and a concomitant increase in the cytotoxic T-lymphocyte infiltration in TEM of the vaccinated animals. Also, CDDO-Me remodeled the tumor associated fibroblasts, collagen and vessel in TME, meanwhile, enhanced the Fas signaling pathway which could sensitize the tumor cells for cytotoxic T lymphocyte mediated killing. The combination of systemic induction of antigen-specific immune response using Trp2 nanovaccine and targeted modification of the TME with the NP delivered CDDO-Me offers a powerful combination therapy for melanoma.
Geometrothermodynamic cosmology
Creators: name: Luongo, Orlando
name: Quevedo, Hernando
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We review the main aspects of geometrothermodynamics, a formalism that uses contact geometry and Riemannian geometry to describe the properties of thermodynamic systems. We show how to handle in a geometric way the invariance of classical thermodynamics with respect to Legendre transformations, which means that the properties of the systems do not depend on the choice of the thermodynamic potential. Moreover, we show that in geometrothermodynamics it is possible to apply a variational principle to generate thermodynamic fundamental equations, which can be used in the context of relativistic cosmology to generate cosmological models. As a particular example, we consider a fundamental equation that relates the entropy with the internal energy and the volume of the Universe, and construct cosmological models with arbitrary parameters, which can be fixed to reproduce the main aspects of the inflationary era and the standard cosmological paradigm.
description: Invited review, 33 pages, 1 figure
(103061) Edith Kathleen Bendall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A VLBI Proper Motion Analysis of the Recoiling Supermassive Black Hole Candidate Mrk 1018
Creators: name: Walsh, Gregory
name: Burke-Spolaor, Sarah
name: Lazio, T. Joseph W.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Mrk 1018 is a nearby changing-look AGN that has oscillated between spectral Type 1.9 and Type 1 over a period of 40 years. Recently, a recoiling supermassive black hole (rSMBH) scenario has been proposed to explain the spectral and flux variability observed in this AGN. Detections of rSMBHs are important for understanding the processes by which SMBH binaries merge and how rSMBHs influence their galactic environment through feedback mechanisms. However, conclusive identification of any rSMBHs has remained elusive to date. In this paper, we present an analysis of 6.5 years of multi-frequency Very Long Baseline Array (VLBA) monitoring of Mrk 1018. We find that the radio emission is compact down to 2.4 pc, and displays flux density and spectral variability over the length of our campaign, typical of a flat spectrum radio core. We observe proper motion in RA of the radio core at -36.4 $\pm$ 8.6 $μ$as yr$^{-1}$ (4.2$σ$), or $0.10c \pm 0.02c$ at the redshift of Mrk 1018. No significant proper motion is found in DEC (31.3 $\pm$ 25.1 $μ$as yr$^{-1}$). We discuss possible physical mechanisms driving the proper motion, including a rSMBH. We conclude that the apparent velocity we observe of the VLBI radio core is too high to reconcile with theoretical predictions of rSMBH velocities and that the proper motion is most likely dominated by an unresolved, outflowing jet component. Future observations may yet reveal the true nature of Mrk 1018. However, our observations are not able to confirm it as a true rSMBH.
description: 17 pages, 7 figures, 3 tables; accepted for publication in ApJ
Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors
Creators: name: Cox, Adrienne D.
name: Hyder, Nabeel
name: Wang, Edina C.
name: Wagner, Kyle T.
name: Min, Yuanzeng
name: Tian, Xi
name: Caster, Joseph M.
name: Palm, Robert C.
name: Wang, Andrew Z.
name: Fiordalisi, James J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Histone deacetylase inhibitors (HDACIs) represent a class of promising agents that can improve radiotherapy in cancer treatment. However, the full therapeutic potential of HDACIs as radiosensitizers has been restricted by limited efficacy in solid malignancies. In this study, we report the development of nanoparticle (NP) formulations of HDACIs that overcome these limitations, illustrating their utility to improve the therapeutic ratio of the clinically established first generation HDACI vorinostat and a novel second generation HDACI quisinostat. We demonstrate that NP HDACIs are potent radiosensitizers in vitro and are more effective as radiosensitizers than small molecule HDACIs in vivo using mouse xenograft models of colorectal and prostate carcinomas. We found that NP HDACIs enhance the response of tumor cells to radiation through the prolongation of γ-H2AX foci. Our work illustrates an effective method for improving cancer radiotherapy treatment.
SINFONI spectra of heavily obscured AGNs in COSMOS: evidence of outflows in a MIR/O target at z$\sim2.5$
Creators: name: Perna, M.
name: Brusa, M.
name: Salvato, M.
name: Cresci, G.
name: Lanzuisi, G.
name: Berta, S.
name: Delvecchio, I.
name: Fiore, F.
name: Lutz, D.
name: Floc'h, E. Le
name: Mainieri, V.
name: Riguccini, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present new data for four candidate obscured Compton-Thick (CT) quasars at z $\sim$1-2.5 observed with SINFONI VLT spectrograph in AO mode. These sources were selected from a 24$μ$m Spitzer MIPS survey of the COSMOS field, on the basis of red mid-infrared-to-optical and optical-to-near-infrared colours, with the intention of identifying active galactic nuclei (AGNs) in dust enshrouded environments, where most of the black hole mass is assembled in dust enshrouded environments. Near infrared spectra were analyzed in order to check for emission line features and to search for broad components in the [OIII]-H$β$ and H$α$-[NII] regions. X-ray spectral analysis, radio and MIR diagnostics, and SED fitting have also been employed to study the nature of the sources. We successfully identified three objects for which we had only a photometric redshift estimate. Based on their emission line diagnostics and on ancillary multi-wavelength constraints, we find that all four targets harbor obscured AGNs. Broad profiles that could be attributed to the effects of outflows are revealed in only one target, MIRO20581. In particular, we clearly resolved a fast ($\sim$1600 km/s) and extended ($\sim$5 kpc) outflow in the [OIII]5007 emission line. This feature, the commonly used indicator for ionised outflowing gas, was sampled and detected only for this target; hence, we can not exclude the presence of outflows in the other sources. Overall, the constraints we obtain from our targets and from other comparative samples from the literature suggest that these optically faint luminous infrared galaxies, hosting obscured AGNs, may represent a brief evolutionary phase between the post-merger starburst and the unobscured QSO phases.
description: 13 pages, 8 figures, accepted for publication in A&A
IT and Lacan / IT i Lacan
Creators: name: Fuks, Adam Mateusz Jan
Publisher: name: Zenodo
Year: 2022
Subjects: lacan
psychoanalysis
lacanian
plt
programming language theory

description: EN Towards formalization of Lacanian Psychoanalysis. The paper applies computer science and mathematical terms to psychoanalytical concepts to aid formalization of Lacanian Psychoanalysis. This paper is a work in progress. PL Ku formalizacji Psychoanalizy Lacanowskiej. W artykule terminy informatyczne i matematyczne stosowane są do pojęć psychoanalitycznych celem formalizacji Psychoanalizy Lacanowskiej. Prace nad artykułem są w toku. https://github.com/aammff/lacan
description: {"references": ["https://github.com/aammff/lacan"]}
(103060) Gertrude Margery Kemp
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Fire smoke dispersion inside and outside of a warehouse building in moderate and strong wind conditions
Creators: name: Węgrzyński, Wojciech
name: Krajewski, Grzegorz
name: Kimbar, Grzegorz
name: Lipecki, Tomasz
Publisher: name: arXiv
Year: 2023
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: A moderate-sized (8 MW) fire was modeled in a warehouse located in an urban area with diverse architecture, under wind conditions. The study investigates the impact of neighboring architecture on the wind field and the resulting effect on smoke control performance and smoke dispersion in the vicinity of the building. 25 CFD simulations were performed using ANSYS Fluent CFD code, for wind velocities of 5 m/s (moderate), 10 m/s (strong) at 12 wind angles each (0 - 330$^\circ$, 30$^\circ$ increment), and at 0 m/s for reference. The results show that the performance of the building smoke venting system was impacted by the wind, reaching 74% - 114% and 78% - 158% of the reference mass flow at moderate and strong wind velocities, respectively. Interestingly, in multiple cases, the exhaust flow rate of the ventilators was increased rather than hindered by the wind. This was attributed to the arrangement of inlets and outlets on the facades and the resulting pressure difference between the wall and roof openings. The smoke plume was highly dependent on the wind angle and the type of architecture upwind and downwind of the fire. Significant urban canyon effects and large vortices forming behind tall buildings were observed, leading to smoke accumulation at a significant distance from the fire.
Child Abuse for Information and Communication Technologies (ICTs)
Creators: name: V.Vasuki
Publisher: name: Zenodo
Year: 2019

description: Information and Communication Technologies (ICTs) – especially
 internet and mobile technologies – are increasingly becoming an
 integral part of children’s lives. More and more children rely on
 them to learn, engage, participate, play, work and socialise. ICTs are
 also proving to be useful in children’s protection. They can be used
 to seek information on services, collect, document and share data,
 and report abuse. Furthermore, ICTs can have an enormous potential
 to overcome many of the challenges vulnerable children face in the
 offline world. For instance, for children with disabilities ICTs can
 serve as valuable tools for accessing services and offer opportunities
 for social inclusion, networking and participation.
 The openness of the internet coupled with the digital divide
 between children, parents, caregivers and teachers can, however,
 leave children exposed to online harm, which can negatively impact
 their personal development and well-being. This is especially the
 case in low and middle-income countries where gaps in overall child
 protection tend to be greater, and digital literacy levels among parents
 and caregivers lower. Examples of potential risks include exposure
 to disturbing or potentially harmful content such as violent images,
 cyberbullying, sexual solicitation (‘online grooming’), circulation of
 child sexual abuse materials and live stream abuse. It is therefore
 important to strike a balance between opportunities and risks that
 the ICTs bring and to better understand what makes some children
 particularly vulnerable to risk of harm, so that protective strategies
 can be effectively targeted.
 UNICEF is increasingly exploring how ICTs can be used in child
 protection programmings such as the facilitation of birth registration,
 rapid family tracing and case management. UNICEF is also engaged
 in advocacy for the criminalization of child sexual abuse materials
 and online grooming of children; the strengthening of institutional
 capacities to implement legislation and policies related to investigation
 and prosecution of cases involving online sexual abuse/exploitation;
 supporting the establishment of comprehensive services for children
 abused/exploited through the internet and mobile phones; raising awareness and building capacities of children, teachers and caregivers on the risks of ICTs and
 protective measures and supporting research projects to enhance the understanding of children’s
 use of ICTs and appropriate responses to violence, exploitation and abuse facilitated through ICTs.
(103055) Emma Clara Miles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.