Discovery of new Trichophyton members, T. persicum and T. spiraliforme spp. nov., as a cause of highly inflammatory tinea cases in Iran and Czechia
Creators: name: Čmoková, Adéla
name: Rezaei-Matehkolaei, Ali
name: Kuklová, Ivana
name: Kolařík, Miroslav
name: Shamsizadeh, Forough
name: Ansari, Saham
name: Gharaghani, Maral
name: Miňovská, Viera
name: Najafzadeh, Mohammad Javad
name: Nouripour‐Sisakht, Sadegh
name: Yaguchi, Takashi
name: Zomorodian, Kamiar
name: Zarrinfar, Hossein
name: Hubka, Vit
Publisher: name: Zenodo
Year: 2021
Subjects: dermatophytosis
molecular epidemiology
multigene phylogeny
skin mycoses
Trichophyton benhamiae complex
zoonotic infections
zoophilic dermatophytes

description: Pathogens from the <i>Trichophyton benhamiae</i> complex are one of the most important causes of animal mycoses with significant zoonotic potential. In the light of the recently revised taxonomy of this complex, we retrospectively identified 38 <i>Trichophyton</i> isolates that could not be resolved in any of the existing species. These strains were isolated from Iranian and Czech patients during molecular epidemiological surveys on dermatophytosis and were predominantly associated with highly inflammatory tinea corporis cases suggesting possible zoonotic etiology. Subsequent phylogenetic (4 markers), population-genetic (10 markers) and phenotypic analyses supported recognition of two novel species. The first species, <i>T.</i> <i>persicum </i>sp. nov., was identified in 36 cases of human dermatophytosis and one case of feline dermatophytosis, mainly in Southern and Western Iran. The second species, <i>T. spiraliforme </i>sp. nov., is only known from a single case of tinea corporis in a Czech patient who probably contracted the infection from a dog. Although the zoonotic source of infections summarized in this study is very likely, little is known about the host spectrum of these pathogens. Awareness of these new pathogens among clinicians should refine our knowledge about their poorly explored geographic distribution.
description: Single-gene alignments (4 fasta files) and combined alignment (1 fasta file) comprising members of the Trichophyton benhamiae complex, including two newly described species. List of Trichophyton strains examined in this study: provenance and results of molecular analyses (1 excel file). Two supplementary Figures S1-S2 (phylogenies) and one Supplementary Table S1 (substitutions in the ITS region). Funding provided by: Ministerstvo Zdravotnictví Ceské Republiky<br>Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100003243<br>Award Number: NU21-05-00681Funding provided by: Univerzita Karlova v Praze<br>Crossref Funder Registry ID: http://dx.doi.org/10.13039/100007397<br>Award Number: 204069: Research Centre ProgramFunding provided by: Akademie Věd České Republiky<br>Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004240<br>Award Number: RVO: 61388971 Long-term Research Development ProjectFunding provided by: National Institutes for Medical Research Development<br>Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100012155<br>Award Number: 958797Funding provided by: Grant-in-aid for JSPS research fellow*<br>Crossref Funder Registry ID: <br>Award Number: 20F20772Funding provided by: Grant-in-aid for JSPS research fellow<br>Crossref Funder Registry ID: <br>Award Number: 20F20772