cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Jacobson--Morozov morphism for Langlands parameters in the relative setting
Creators: name: Meli, Alexander Bertoloni
name: Imai, Naoki
name: Youcis, Alex
Publisher: name: arXiv
Year: 2022
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We construct a moduli space $\mathsf{LP}_G$ of $\mathrm{SL}_2$-parameters over $\mathbb{Q}$, and show that it has good geometric properties (e.g. explicitly parametrized geometric connected components and smoothness). We construct a Jacobson--Morozov morphism $\mathsf{JM}\colon \mathsf{LP}_G\to\mathsf{WDP}_G$ (where $\mathsf{WDP}_G$ is the moduli space of Weil--Deligne parameters considered by several other authors). We show that $\mathsf{JM}$ is an isomorphism over a dense open of $\mathsf{WDP}_G$, that it induces an isomorphism between the discrete loci $\mathsf{LP}^{\mathrm{disc}}_G\to\mathsf{WDP}_G^{\mathrm{disc}}$, and that for any $\mathbb{Q}$-algebra $A$ it induces a bijection between Frobenius semi-simple equivalence classes in $\mathsf{LP}_G(A)$ and Frobenius semi-simple equivalence classes in $\mathsf{WDP}_G(A)$ with constant (up to conjugacy) monodromy operator.
description: 41 pages
On the convergence of Magnetorotational turbulence in stratified isothermal shearing boxes
Creators: name: Bodo, G.
name: Cattaneo, F.
name: Mignone, A.
name: Rossi, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We consider the problem of convergence in stratified isothermal shearing boxes with zero net magnetic flux. We present results with the highest resolution to-date--up to 200 grid-point per pressure scale height--that show no clear evidence of convergence. Rather, the Maxwell stresses continue to decrease with increasing resolution. We propose some possible scenarios to explain the lack of convergence based on multi-layer dynamo systems.
description: 10 pages, 4 figures, accepted for publication in ApJ Letters
A Euclidean Fourier-analytic approach to vertical projections in the Heisenberg group
Creators: name: Harris, Terence L. J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 28A78, 28A80

description: An improved a.e. lower bound is given for Hausdorff dimension under vertical projections in the first Heisenberg group, with respect to the Carnot-Carathéodory metric. This improves the known lower bound, and answers a question of Fässler and Hovila. The approach uses the Euclidean Fourier transform, Basset's integral formula, and modified Bessel functions of the second kind.
description: 16 pages. V2: Some minor refinements to Lemma 3.1, and added some background on Bessel functions. V3: Minor corrections V4: Minor corrections and added some concluding remarks. V5: Simplified proof of Lemma 3.2. V6: Minor corrections. Accepted version
Additional file 1 of An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases
Creators: name: Robert, Jerome
name: Weilinger, Nicholas L.
name: Cao, Li-Ping
name: Cataldi, Stefano
name: Button, Emily B.
name: Stukas, Sophie
name: Martin, Emma M.
name: Seibler, Philip
name: Gilmour, Megan
name: Caffrey, Tara M.
name: Elyn M. Rowe
name: Jianjia Fan
name: MacVicar, Brian
name: Farrer, Matthew J.
name: Wellington, Cheryl L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Additional file 1: Supplemental Figure 1. Histological structure of human arterial NVU. a) Human cortex (Brodmann area 9) were stained against a) vWF (EC marker), αSMA (SMC marker) and GFAP (astrocyte marker) and against b) MAP 2 (neuron marker), αSMA (SMC marker) and GFAP (astrocyte marker) to visualize the cerebrovasculature.
Anomalous $HZγ$ couplings in photon-induced collisions at the LHC
Creators: name: Senol, A.
name: Tasci, A. T.
name: Cakir, I. T.
name: Cakir, O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We have examined $HZγ$ vertex to obtain the limits on anomalous $a_γ$, $b_γ$ and $\tilde b_γ$ couplings in a model independent way through the $γp$ collisions via the process $pp\to p γp\to pHqX$. The sensitivities to the anomalous couplings can be obtained as $|b_γ|$, $|\tilde{b}_γ|\sim 10^{-3}$ for the integrated luminosity of $L_{int}=100 ~\mathrm{fb}^{-1}$ at the LHC with $\sqrt{s}=14$ TeV.
description: 10 pages, 7 figures, 3 tables
Mathematische Textaufgaben lesen, verstehen und lösen. Ein systematischer Review zu wirksamen Förderinterventionen
Creators: name: Keller, Marlis
Publisher: name: Zenodo
Year: 2022
Subjects: Sonderpädagogik
Masterarbeit
Mathematische Textaufhaben
Förderinterventionen

description: Sprache ist in allen mathematischen Themen ein wichtiger Faktor. An das Lesen, Verstehen und Lösen von mathematischen Textaufgaben sind spezifische Kompetenzen gebunden. Der Aufbau dieser Fertigkeiten stellt für alle Lernenden auf der Primarstufe eine Herausforderung dar. Für Kinder mit sprachlichen Schwierigkeiten bedeuten sie eine enorme Hürde. Die theoretische Forschung beschäftigt sich seit über vierzig Jahre mit der Thematik. Vor einiger Zeit entdeckte die empirische Wissenschaft das komplexe Thema und untersucht fachspezifische Strategien. In der evidenzbasierten Forschung liegen darüber bislang wenige Studien vor. Das Ziel dieser Arbeit ist es, mittels systematischem Review die Wirksamkeit von Förderinterventionen auf der Primarstufe zu untersuchen. Die Auswertungen zeigen die Möglichkeiten und Einschränkungen von Interventionen zu Textaufgaben auf und spiegeln die aktuelle, spezifische Forschung wider.
Additional file 3 of An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases
Creators: name: Robert, Jerome
name: Weilinger, Nicholas L.
name: Cao, Li-Ping
name: Cataldi, Stefano
name: Button, Emily B.
name: Stukas, Sophie
name: Martin, Emma M.
name: Seibler, Philip
name: Gilmour, Megan
name: Caffrey, Tara M.
name: Elyn M. Rowe
name: Jianjia Fan
name: MacVicar, Brian
name: Farrer, Matthew J.
name: Wellington, Cheryl L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Additional file 3: Supplemental Figure 3. Aβ40 and Aβ42 concentration in circulation media. (a) Aβ40 and (b) Aβ42 levels in circulation media of tissue composed of EC and SCM (bipartite), EC, SMC and astrocyte (tripartite) and EC, SMC, astrocytes and neurons (NVU) after 1 or 3 weeks in culture were quantified by ELISA. Points in graphed data represent individual bioengineered vessels, bars represent mean, error bars represent ±SEM and analysed by one way ANOVA. Values below the detection of the ELISA are plotted in gray. * = p
Linear and quadratic static response functions and structure functions in Yukawa liquids
Creators: name: Magyar, P.
name: Donko, Z.
name: Kalman, G. J.
name: Golden, K. I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We compute linear and quadratic static density response functions of three-dimensional Yukawa liquids by applying an external perturbation potential in molecular dynamics simulations. The response functions are also obtained from the equilibrium fluctuations (static structure factors) in the system via the fluctuation-dissipation theorems. The good agreement of the quadratic response functions, obtained in the two different ways confirms the quadratic fluctuation-dissipation theorem. We also find that the three-point structure function may be factorizable into two-point structure functions, leading to a cluster representation of the equilibrium triplet correlation function.
Comprehensive Analyses of the Neutrino-Process in the Core-collapsing Supernova
Creators: name: Ko, Heamin
name: Jang, Dukjae
name: Cheoun, Myung-Ki
name: Kusakabe, Motohiko
name: Sasaki, Hirokazu
name: Yao, Xingqun
name: Kajino, Toshitaka
name: Hayakawa, Takehito
name: Ono, Masaomi
name: Kawano, Toshihiko
name: Mathews, Grant J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the neutrino flavor change effects due to neutrino self-interaction, shock wave propagation as well as matter effect on the neutrino-process of the core-collapsing supernova (CCSN). For the hydrodynamics, we use two models: a simple thermal bomb model and a specified hydrodynamic model for SN1987A. As a pre-supernova model, we take an updated model adjusted to explain the SN1987A employing recent development of the $(n,γ)$ reaction rates for nuclei near the stability line $(A \sim 100)$. As for the neutrino luminosity, we adopt two different models: equivalent neutrino luminosity and non-equivalent luminosity models. The latter is taken from the synthetic analyses of the CCSN simulation data which involved quantitatively the results obtained by various neutrino transport models. Relevant neutrino-induced reaction rates are calculated by a shell model for light nuclei and a quasi-particle random phase approximation model for heavy nuclei. For each model, we present abundances of the light nuclei ($^7$Li, $^7$Be, $^{11}$B and $^{11}$C) and heavy nuclei ($^{92}$Nb, $^{98}$Tc, $^{138}$La and $^{180}$Ta) produced by the neutrino-process. The light nuclei abundances turn out to be sensitive to the Mikheyev-Smirnov-Wolfenstein (MSW) region around O-Ne-Mg region while the heavy nuclei are mainly produced prior to the MSW region. Through the detailed analyses, we find that neutrino self-interaction becomes a key ingredient in addition to the MSW effect for understanding the neutrino-process and the relevant nuclear abundances. The normal mass hierarchy is shown to be more compatible with the meteorite data. Main nuclear reactions for each nucleus are also investigated in detail.
Higher Gauging and Non-invertible Condensation Defects
Creators: name: Roumpedakis, Konstantinos
name: Seifnashri, Sahand
name: Shao, Shu-Heng
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We discuss invertible and non-invertible topological condensation defects arising from gauging a discrete higher-form symmetry on a higher codimensional manifold in spacetime, which we define as higher gauging. A $q$-form symmetry is called $p$-gaugeable if it can be gauged on a codimension-$p$ manifold in spacetime. We focus on 1-gaugeable 1-form symmetries in general 2+1d QFT, and gauge them on a surface in spacetime. The universal fusion rules of the resulting invertible and non-invertible condensation surfaces are determined. In the special case of 2+1d TQFT, every (invertible and non-invertible) 0-form global symmetry, including the $\mathbb{Z}_2$ electromagnetic symmetry of the $\mathbb{Z}_2$ gauge theory, is realized from higher gauging. We further compute the fusion rules between the surfaces, the bulk lines, and lines that only live on the surfaces, determining some of the most basic data for the underlying fusion 2-category. We emphasize that the fusion "coefficients" in these non-invertible fusion rules are generally not numbers, but rather 1+1d TQFTs. Finally, we discuss examples of non-invertible symmetries in non-topological 2+1d QFTs such as the free $U(1)$ Maxwell theory and QED.
description: 83 pages; v2: published version; v3: minor revision
Cell Ablation in Transgenic Mice
Creators: name: Markkula, Merja
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: The toxigcne approach. in which the toxic gene product is guided by the cell specific promoter to the desired tissue. is an effective way of ablating cells both in germline transgenic mice and also in somatic transgenic tissues. It opens up new possibilities for physiological and cell lineage studies and gene therapy of tumors. The more effective targeting of toxigcnes into the genome and timing of their expression will further increase their applicability.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Sisyphus Effect in Pulse Coupled Excitatory Neural Networks with Spike-Timing Dependent Plasticity
Creators: name: Mikkelsen, Kaare
name: Imparato, Alberto
name: Torcini, Alessandro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Chaotic Dynamics (nlin.CD)
subject: Biological Physics (physics.bio-ph)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The collective dynamics of excitatory pulse coupled neural networks with spike timing dependent plasticity (STDP) is studied. Depending on the model parameters stationary states characterized by High or Low Synchronization can be observed. In particular, at the transition between these two regimes, persistent irregular low frequency oscillations between strongly and weakly synchronized states are observable, which can be identified as infraslow oscillations with frequencies 0.02 - 0.03 Hz. Their emergence can be explained in terms of the Sisyphus Effect, a mechanism caused by a continuous feedback between the evolution of the coherent population activity and of the average synaptic weight. Due to this effect, the synaptic weights have oscillating equilibrium values, which prevents the neuronal population from relaxing into a stationary macroscopic state.
description: 18 pages, 24 figures, submitted to Physical Review E
Criticality and Phase Classification for Quadratic Open Quantum Many-Body Systems
Creators: name: Zhang, Yikang
name: Barthel, Thomas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the steady states of translation-invariant open quantum many-body systems governed by Lindblad master equations, where the Hamiltonian is quadratic in the ladder operators, and the Lindblad operators are either linear or quadratic and Hermitian. These systems are called quasifree and quadratic, respectively. We find that steady states of one-dimensional systems with finite-range interactions necessarily have exponentially decaying Green's functions. For the quasifree case without quadratic Lindblad operators, we show that fermionic systems with finite-range interactions are noncritical for any number of spatial dimensions and provide bounds on the correlation lengths. Quasifree bosonic systems can be critical in $D>1$ dimensions. Last, we address the question of phase transitions in quadratic systems and find that, without symmetry constraints beyond invariance under single-particle basis and particle-hole transformations, all gapped Liouvillians belong to the same phase.
description: 13 pages, 2 figures; minor improvements and additional references; published version. The employed methods for the solution of quasi-free and quadratic open systems are described in arXiv:2112.08344
T cell Receptor αβ Transgenic Mice in Immunological Research
Creators: name: Bogen, Bjarne
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: T cell receptor transgenic mice have had an increasingly large impact on immunological research for the last 8 years during which such mice have been available. The mice have been important to further our understanding of T cell receptor acquisition and thymocyte development. In the coming years, it is anticipated that the mice will contribute to our apprehension of peripheral T cell activation and differentiation, and to the role of T cells in disease states.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Cosmology in $f(R,L_m)$ gravity
Creators: name: Jaybhaye, Lakhan V.
name: Solanki, Raja
name: Mandal, Sanjay
name: Sahoo, P. K.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this letter, we investigate the cosmic expansion scenario of the universe in the framework of $f(R,L_m)$ gravity theory. We consider a non-linear $f(R,L_m)$ model, specifically, $f(R,L_m)=\frac{R}{2}+L_m^n + β$, where $n$ and $β$ are free model parameters. Then we derive the motion equations for flat FLRW universe and obtain the exact solution of corresponding field equations. Then we estimate the best fit ranges of model parameters by using updated $H(z)$ datasets consisting of 57 points and the Pantheon datasets consisting of 1048 points. Further we investigate the physical behavior of density and the deceleration parameter. The evolution of deceleration parameter depicts a transition from deceleration to acceleration phases of the universe. Moreover, we analyze the stability of the solution of our cosmological model under the observational constraint by considering a linear perturbation. Lastlty, we investigate the behavior of Om diagnostic parameter and we observe that our model shows quintessence type behavior. We conclude that our $f(R,L_m)$ cosmological model agrees with the recent observational studies and can efficiently describe the late time cosmic acceleration.
description: PLB published version
NISQ algorithm for the matrix elements of a generic observable
Creators: name: Erbanni, Rebecca
name: Bharti, Kishor
name: Kwek, Leong-Chuan
name: Poletti, Dario
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The calculation of off-diagonal matrix elements has various applications in fields such as nuclear physics and quantum chemistry. In this paper, we present a noisy intermediate scale quantum algorithm for estimating the diagonal and off-diagonal matrix elements of a generic observable in the energy eigenbasis of a given Hamiltonian. Several numerical simulations indicate that this approach can find many of the matrix elements even when the trial functions are randomly initialized across a wide range of parameter values without, at the same time, the need to prepare the energy eigenstates.
Transgenic Mice as Immunogenicity Model
Creators: name: Ottesen, Jan L
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: The development of antibodies after administration of pharmaceutical proteins is not only of academic interest. Antibodies can be responsible for local and systemic allergic reactions, injection site lipoatrophy and have effect on the dose requirements.Tolerant transgenic mice are used to evaluate the potential immunogenicity of pharmaceutical proteins, e.g.. human insulin. human tissue plasminogen activator and human growth hormone. The results indicate that transgenic mice should be useful as an in vivo model to map immunogenic epitopes. Transgenic mice with tissue specific expression of human insulin that are tolerant to human insulin (in contrast to their nontransgenic littermates that produce antibodies) are able to respond with antibody formation against human insulin With substitution of single amino acids, if the substitutions results in immunogenic epitopes. Finally potential future immunogenicity models are discussed.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Interpolating between small- and large-$g$ expansions using Bayesian Model Mixing
Creators: name: Semposki, A. C.
name: Furnstahl, R. J.
name: Phillips, D. R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Bayesian Model Mixing (BMM) is a statistical technique that can be used to combine models that are predictive in different input domains into a composite distribution that has improved predictive power over the entire input space. We explore the application of BMM to the mixing of two expansions of a function of a coupling constant $g$ that are valid at small and large values of $g$ respectively. This type of problem is quite common in nuclear physics, where physical properties are straightforwardly calculable in strong and weak interaction limits or at low and high densities or momentum transfers, but difficult to calculate in between. Interpolation between these limits is often accomplished by a suitable interpolating function, e.g., Padé approximants, but it is then unclear how to quantify the uncertainty of the interpolant. We address this problem in the simple context of the partition function of zero-dimensional $ϕ^4$ theory, for which the (asymptotic) expansion at small $g$ and the (convergent) expansion at large $g$ are both known. We consider three mixing methods: linear mixture BMM, localized bivariate BMM, and localized multivariate BMM with Gaussian processes. We find that employing a Gaussian process in the intermediate region between the two predictive models leads to the best results of the three methods. The methods and validation strategies we present here should be generalizable to other nuclear physics settings.
description: 14 pages, 11 figures, with supplemental material
Additional file 4 of An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases
Creators: name: Robert, Jerome
name: Weilinger, Nicholas L.
name: Cao, Li-Ping
name: Cataldi, Stefano
name: Button, Emily B.
name: Stukas, Sophie
name: Martin, Emma M.
name: Seibler, Philip
name: Gilmour, Megan
name: Caffrey, Tara M.
name: Elyn M. Rowe
name: Jianjia Fan
name: MacVicar, Brian
name: Farrer, Matthew J.
name: Wellington, Cheryl L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Additional file 4: Supplemental Figure 4. Aβ and p-tau histology. Cryopreserved bioengineered arterial NVU were cut longitudinally to show a cross-section of the NVU wall. a) Immunohistochemistry against OC fibril confirmed the deposition of Aβ fibril both in the neuron layer (β-tub III positive, white arrow) as well as deeper in the vascular wall (blue arrows). b) The expression of Aβ was further investigated by staining against Aβ 1–16. Positive signal was found both deep in the vascular wall (white arrow) as well as co-localized within MAP 2 positive cells (yellow arrow). c) Immunohistochemistry against AT8 suggest the deposition of p-tau both within neuron (MAP 2 positive, yellow arrow) as well as extracellular (white arrow), purple arrow shows the remaining of the scaffold. Human brains were used as representative staining pattern. ABL = albumen.
Inflationary Tensor Perturbation in Eddington-inspired Born-Infeld gravity
Creators: name: Cho, Inyong
name: Kim, Hyeong-Chan
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the tensor perturbation in the inflation model driven by a massive-scalar field in Eddington-inspired Born-Infeld gravity. For short wave-length modes, the perturbation feature is very similar to that of the usual chaotic inflation. For long wave-length modes, the perturbation exhibits a peculiar rise in the power spectrum which may leave a signature in the cosmic microwave background radiation.
description: 14 pages, 4 figures
Insulin gene regulation and islet development as studied in genetically modified tumors and transgenic laboratory animals
Creators: name: Madsen, Ole D
name: Petersen, Helle V
name: Blume, Niels
name: Karlsen, Christina
name: Lund, Kaare
name: Serup, Palle
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: The pancreatic islet of Langerhans is composed of four highly distinct cell types specialized to mass produce a particular hormone. Insulin is thus the main product released from the islet B—cell in response to elevated glucose.The four cell types maturate during fetal development. Pluripotent rat islet tumors can to a certain degree undergo similar maturation processes when passaged in vivo. Such a model has been used to study the B—cell specific process of insulin gene activation. Transgenic mice have been instrumental in defining the functional regulatory elements involved in restricting the insulin gene activity to the pancreatic B-cell. The tissue-specific enhancer/promoter has thus been identified and used in combination with a series of other genes which in transgenic mice targets expression of the gene in question selectively to the B-cell. Important transacting factors have been identified and cloned which are in part responsible for mediating tissue specific insulin gene expression. One such factor when "knocked-out" results in a phenotype lacking the entire pancreas. Future developments in targeting "knockout" of genes to particular cell types will help dissecting out the multiple functions of such regulatory transacting factors.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Old pre-main-sequence Stars: Disc reformation by Bondi-Hoyle accretion
Creators: name: Scicluna, P.
name: Rosotti, G.
name: Dale, J. E.
name: Testi, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Young stars show evidence of accretion discs which evolve quickly and disperse with an e-folding time of $\sim$ 3Myr. This is in striking contrast with recent observations that suggest evidence for numerous $>30$ Myr old stars with an accretion disc in large star-forming complexes. We consider whether these observations of apparently old accretors could be explained by invoking Bondi-Hoyle accretion to rebuild a new disc around these stars during passage through a clumpy molecular cloud. We combine a simple Monte Carlo model to explore the capture of mass by such systems with a viscous evolution model to infer the levels of accretion that would be observed. We find that a significant fraction of stars may capture enough material via the Bondi-Hoyle mechanism to rebuild a disc of mass $\gtrsim$ 1 minimum-mass solar nebula, and $\lesssim 10\%$ accrete at observable levels at any given time. A significant fraction of the observed old accretors may be explained with our proposed mechanism. Such accretion may provide a chance for a second epoch of planet formation, and have unpredictable consequences for planetary evolution.
description: 5 pages, 2 figures. Accepted by A&A
Evaluating histopathology transfer learning with ChampKit
Creators: name: Kaczmarzyk, Jakub R.
name: Kurc, Tahsin M.
name: Abousamra, Shahira
name: Gupta, Rajarsi
name: Saltz, Joel H.
name: Koo, Peter K.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: J.3; I.4.9; D.2.13

description: Histopathology remains the gold standard for diagnosis of various cancers. Recent advances in computer vision, specifically deep learning, have facilitated the analysis of histopathology images for various tasks, including immune cell detection and microsatellite instability classification. The state-of-the-art for each task often employs base architectures that have been pretrained for image classification on ImageNet. The standard approach to develop classifiers in histopathology tends to focus narrowly on optimizing models for a single task, not considering the aspects of modeling innovations that improve generalization across tasks. Here we present ChampKit (Comprehensive Histopathology Assessment of Model Predictions toolKit): an extensible, fully reproducible benchmarking toolkit that consists of a broad collection of patch-level image classification tasks across different cancers. ChampKit enables a way to systematically document the performance impact of proposed improvements in models and methodology. ChampKit source code and data are freely accessible at https://github.com/kaczmarj/champkit .
description: Submitted to NeurIPS 2022 Track on Datasets and Benchmarks. Source code available at https://github.com/kaczmarj/champkit
Counterintuitive temporal shape of single photons
Creators: name: Gulati, Gurpreet Kaur
name: Srivathsan, Bharath
name: Chng, Brenda
name: Cerè, Alessandro
name: Matsukevich, Dzmitry
name: Kurtsiefer, Christian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We prepare heralded single photons from a photon pair source based on non-degenerate four-wave mixing in a cold atomic ensemble via a cascade decay scheme. Their statistics shows strong antibunching with g(2)(0) < 0.03, indicating a near single photon character. In an optical homodyne experiment, we directly measure the temporal envelope of these photons and find, depending on the heralding scheme, an exponentially decaying or rising profile. The rising envelope will be useful for efficient interaction between single photons and microscopic systems like single atoms and molecules. At the same time, their observation illustrates the breakdown of a realistic interpretation of the heralding process in terms of defining an initial condition of a physical system.
description: 4 pages, 4 figures
ASSESSMENT OF ASSOCIATION BETWEEN PARENTAL FEEDING PRACTICE AND CHILDREN EATING BEHAVIOR AMONG PRESCHOOL CHILDREN IN ADDIS ABABA
Creators: name: Nardos Wondafrash
Publisher: name: Zenodo
Year: 2019

description: Background: Low and middle-income countries are facing both extremes of public health nutrition problems. Despite the well-established risk factors of mal-nutrition, individual differences in eating behaviors may contribute to the existing variation in nutritional status. Eating behaviors are biological and behavioral processes directed towards meeting bodily requirements; and these behaviors develop during the first years of life. Eating behaviors can be categorized as food approach and food avoidant. Some of the food approach behaviors are enjoyment of food (EF), food responsiveness (FR), emotional overeating (EOE), desire to drink (DD), and food avoidant behaviors are satiety responsiveness (SR), slowness in eating (SE), emotional under eating (EUE) and food fussiness (FF). Parents and caregivers influence their children’s eating behavior through communicating their attitudes and beliefs about food and feeding.

Objective: To assess the different eating behaviors of preschool children and to determine its association with parental feeding practice in Addis Ababa.
Cloud Disruption via Ionized Feedback: Tracing Pillar Dynamics in Vulpecula
Creators: name: Klaassen, P. D.
name: Mottram, J. C.
name: Dale, J. E.
name: Juhasz, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The major physical processes responsible for shaping and sculpting pillars in the clouds surrounding massive stars (i.e. the `Pillars of Creation') are now being robustly incorporated into models quantifying the ionizing radiation from massive stars. The detailed gas dynamics within these pillars can now be compared with observations. Our goal is to quantify the gas dynamics in a pillar being sculpted by a nearby massive star. To do this, we use the CO, $^{13}$CO, and C$^{18}$O J=1-0 emission towards a pillar in the Vulpecula Rift. These data are a combination of CARMA and FCRAO observations providing high resolution ($\sim5''$) imaging of large scale pillar structures ($>100''$). We find that this cold ($\sim18$ K), low density material ($8\times10^3$ cm$^{-3}$) material is fragmenting on Jeans scales, has very low velocity dispersions ($\sim0.5$ km s$^{-1}$), and appears to be moving away from the ionizing source. We are able to draw direct comparisons with three models from the literature, and find that those with lower velocity dispersions best fit our data, although the dynamics of any one model do not completely agree with our observations. We do however, find that our observed pillar exhibits many of the characteristics expected from simulations.
description: 8 pages, including 7 figures. Accepted for publication in MNRAS
Transgenic laboratory animals in cystic fibrosis research
Creators: name: Krogh Johansen, Helle
name: Holby, Niels
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: Cystic fibrosis (CF) is the most common fatal autosomal recessive genetic disorder in Caucasian populations. The incidence in Denmark is approximately 1:4500 and about 50.000 CF patients are registred in Europe and the Americas.The disease is characterized by malabsorption due to exocrine pancreatic insufficiency, chronic bacterial infections in the lower respiratory tract, increased salt loss in sweat, and male infertility due to absence or stenosis of the vas deferens. The CF gene was identified on Chromosome 7 in 1989. More than 450 different mutations have been detected, the most common being the AF508.This gene encodes for the cystic fibrosis transmembrane regulator protein (CFTR) which is a Cl' channel regulated by protein kinase C and ATP. It facilitates transport of Cl' and other ions through the cell membrane. Two years ago. three different groups of scientists published articles describing three different variants of CF mice (>>knock—out<< mice). Two of these mice suffer from severe CF-like symptoms. especially in the intestine. and most of them die within 3 weeks. The last one has some residual CFTR activity and survives for several months. These mice allow investigations on gene therapy using different vectors and investigations on the pathogenesis of the chronic Pseudomonas aeruginosa lung infection to be carried out. Thus. the prospects for understanding CF seems promising.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Witnessing entanglement in hybrid systems
Creators: name: Borrelli, Massimo
name: Rossi, Matteo
name: Macchiavello, Chiara
name: Maniscalco, Sabrina
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We extend the definition of entanglement witnesses based on structure factors to the case in which the position of the scatterers is quantized. This allows us to study entanglement detection in hybrid systems. We provide several examples that show how these extra degrees of freedom affect the detection of entanglement by directly contributing to the measurement statistics. We specialize the proposed witness operators for a chain of trapped ions. Within this framework, we show how the collective vibronic state of the chain can act as an undesired quantum environment and how ions quantum motion can affect the entanglement detection. Finally, we investigate some specific cases where the method proposed leads to detection of hybrid entanglement.
description: 6 pages, 4 figures
Transgenic laboratory animal models in atherosclerosis research
Creators: name: Mortensen, Alicja
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: Atherosclerosis and its clinical sequela coronary heart disease is a major cause of death in the modern world. It is caused by a complex interaction between genetical and environmental factors. Over the last decade the development of transgenic techniques and the isolation of human genes coding for proteins that directly interact with plasma lipids made it possible to create new transgenic animal models in atherosclerosis research. Several transgenic mouse lines have now been established that overexpress many of the lipoprotein transport genes. Additionally, the technique of homologous recombination in embryonic stem cells has been used to knock out lipoprotein transport genes. The new models allow in Vivo investigation of over- or underexpression or total lack of different lipoprotein transport genes on development of atherosclerosis under controlled conditions. The models are a promising tool for studying the effect of drugs, diet and chosen environmental factors on atherosclerosis, and will facilitate thelunderstanding of the pathophysiology of atherosclerotic lesions.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Ruling Out New Physics at Low Redshift as a solution to the $H_0$ Tension
Creators: name: Keeley, Ryan E.
name: Shafieloo, Arman
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We make the case that there can be no low-redshift solution to the $H_0$ tension. To robustly answer this question, we use a very flexible parameterization for the dark energy equation of state such that every cosmological distance still allowed by data exists within this prior volume. To then answer whether there exists a satisfactory solution to the $H_0$ tension within this comprehensive parameterization, we constrained the parametric form using different partitions of the Planck cosmic microwave background, SDSS-IV/eBOSS DR16 baryon acoustic oscillation, and Pantheon supernova datasets. When constrained by just the cosmic microwave background dataset, there exists a set of equations of state which yields high $H_0$ values, but these equations of state are ruled out by the combination of the supernova and baryon acoustic oscillation datasets. In other words, the constraint from the cosmic microwave background, baryon acoustic oscillation, and supernova datasets together does not allow for high $H_0$ values and converges around an equation of state consistent with a cosmological constant. Thus, since this very flexible parameterization does not offer a solution to the $H_0$ tension, there can be no solution to the $H_0$ tension that adds physics at only low redshifts. This is directly related to the expansion history of the Universe and its geometrical properties and would include models beyond those parametrized by $w(z)$.
description: 7 pages, 7 figures
Nécrose et infection locales compliquant une envenimation par Echis ocellatus chez un enfant au Mali
Creators: name: KEITA, Moussa
name: COULIBALY, Sanou Khô
name: SANOGO, Sanra Déborah
Publisher: name: MTSI
Year: 2023

description: Local necrosis and infection complicating envenomation with Echis ocellatus in a child in Mali Abstract A 4-year-old child living with his parents in Kolokani, a town about 100 km from Bamako, was bitten on the left index finger by a snake of the species Echis ocellatus (fonfoni in local language). After 2 weeks of traditional treatment, local complications were observed. The child was admitted to the Néné clinic in Kati (Mali) on 19 July 2022. The signs observed were correlated with the degree of enve-nomation and the whole blood coagulation test showed coagulation disorders, which justified the ad-ministration of antivenom. Necrosis of the whole index finger required amputation of the finger, which was not followed by any complications. Snakebites require proper management to prevent complica-tions such as necrosis and infection of the bite site. Administration of antivenom is necessary if coagu-lation disorders persist. Surgical treatment and broad-spectrum antibiotic therapy may improve the prognosis. Nécrose et infection locales compliquant une envenimation par Echis ocellatus chez un enfant au Mali Un enfant de 4 ans, vivant avec ses parents à Kolokani, une localité située à une centaine de kilomètres de Bamako a été mordu au niveau de l’index gauche par un serpent de l’espèce Echis ocellatus (fonfoni en langue locale). Après 2 semaines de traitement traditionnel, des complications locales ont été observées. L’enfant a été admis à la clinique Néné de Kati (Mali) le 19 juillet 2022. Les signes observés avaient été corrélés au degré d’envenimation et le test de coagulation sur tube sec avait montré des troubles de la coagulation, ce qui avait justifié l’administration d’antivenin. En raison d’une nécrose de la totalité de l’index, une amputation a été réalisée, avec des suites simples. Les morsures de serpent nécessitent une prise en charge adéquate afin de prévenir des complications telles que la nécrose et l’infection du site de morsure. L’administration d’antivenin est nécessaire si les troubles de la coagulation persistent. Un traitement chirurgical et une antibiothérapie à large spectre peuvent améliorer le pronostic vital.
description: MTSI, Vol. 3 No 1 (2023): MTSI-Revue
Transgenic Mice in Carcinogenicity Testing
Creators: name: Kryspin-Sorensen, Ilona
Publisher: name: Scandinavian Journal of Laboratory Animal Sciences
Year: 2019

description: The ability to transfer oncogenes into the germline of animals, which became available over 10 years ago has contributed to our understanding of the function of oncogenes and their role in genetic diseases and cancer. Studies have been conducted with transgenics to assess the usefulness of transgenic mice in short term carcinogenicity testing. The next decade should bring about the characterisation of transgenic animal models that are susceptible to carcinogens leading to a more rapid and precise categorisation of genotoxic carcinogens and to a better understanding of the role of genetic events in the process that results in cancer caused by chemical carcinogens.
description: Scandinavian Journal of Laboratory Animal Sciences, Vol. 22 No. 2 (1995)
Multichannel Quantum Defect Theory of Strontium Rydberg Series
Creators: name: Vaillant, C L
name: Jones, M P A
name: Potvliege, R M
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Using the reactance matrix approach, we systematically develop new multichannel quantum defect theory models for the singlet and triplet S, P, D and F states of strontium based on improved energy level measurements. The new models reveal additional insights into the character of doubly excited perturber states, and the improved energy level measurements for certain series allow fine structure to be resolved for those series' perturbers. Comparison between the predictions of the new models and those of previous empirical and \emph{ab initio} studies reveals good agreement with most series, however some discrepancies are highlighted. Using the multichannel quantum defect theory wave functions derived from our models we calculate other observables such as Landé $g_J$-factors and radiative lifetimes. The analysis reveals the impact of perturbers on the Rydberg state properties of divalent atoms, highlighting the importance of including two-electron effects in the calculations of these properties. The work enables future investigations of properties such as Stark maps and long-range interactions of Rydberg states of strontium.
description: 22 pages, 14 figures
Additional file 1 of The attachment process and physiological properties of Escherichia coli O157:H7 on quartz
Creators: name: Liliang Wang
name: Yichao Wu
name: Cai, Peng
name: Qiaoyun Huang
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Differentially expressed genes and proteins during attachment; the y-axis of the graph represents the number of up- and downregulated genes and proteins in attached cells compared to planktonic cells. Figure S2. Schematic diagram of the structure of the vector plasmid PMD18-T. Table S1. Summary of protein identification in the attached and planktonic E. coli O157:H7 using the iTRAQ platform. Table S2. Deleted genes and their primers used in this study. Table S3. Significantly enriched KEGG pathways in either transcriptomic or proteomic data. Table S4. Significantly enriched GO terms in both transcriptomic and proteomic data. Table S5. Differentially altered proteins and genes associated with metabolism. Table S6. Differentially altered proteins and genes associated with general stress response and antibiotic resistance. Table S7. PCR primers used in this study.