cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation
Creators: name: Lu, Guang
name: Yi, Juan
name: Gubas, Andrea
name: Wang, Ya-Ting
name: Wu, Yihua
name: Ren, Yi
name: Wu, Man
name: Shi, Yin
name: Ouyang, Chenxi
name: Tan, Hayden Weng Siong
name: Wang, Tianru
name: Wang, Liming
name: Yang, Nai-Di
name: Deng, Shuo
name: Xia, Dajing
name: Chen, Ruey-Hwa
name: Tooze, Sharon A.
name: Shen, Han-Ming
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded by lysosome in response to various stress conditions. Apart from its role in the maintenance of cellular homeostasis, autophagy also involves in regulation of cell cycle progression under nutrient-deprivation conditions. However, whether and how autophagy is regulated by the cell cycle especially during mitosis remains largely undefined. Here we show that WIPI2/ATG18B (WD repeat domain, phosphoinositide interacting 2), an autophagy-related (ATG) protein that plays a critical role in autophagosome biogenesis, is a direct substrate of CUL4-RING ubiquitin ligases (CRL4s). Upon mitosis induction, CRL4s are activated via neddylation, and recruit WIPI2 via DDB1 (damage specific DNA binding protein 1), leading to polyubiquitination and proteasomal degradation of WIPI2 and suppression of autophagy. The WIPI2 protein level and autophagy during mitosis could be rescued by knockdown of CRL4s or treatment with MLN4924/Pevonedistat, a selective inhibitor of CRLs, via suppression of NAE1 (NEDD8 activating enzyme E1 subunit 1). Moreover, restoration of WIPI2 rescues autophagy during mitosis and leads to mitotic slippage and cell senescence. Our study thus discovers a novel function of CRL4s in autophagy by targeting WIPI2 for polyubiquitination and proteasomal degradation during mitosis. Abbreviations: ACTB, actin beta; ATG, autophagy-related; AMPK, AMP-activated protein kinase; AURKB/ARK2, aurora kinase B; BafA1, bafilomycin A1; CCNB1, cyclin B1; CDK1, cyclin dependent kinase 1; CHX, cycloheximide; CQ, chloroquine; CRL4s, CUL4-RING ubiquitin ligases; DDB1, damage specific DNA binding protein 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GFP, green fluorescent protein; GST, glutathione S-transferase; MAP1LC3B/LC3B, microtubule associated protein 1 light chain 3 beta; STK11/LKB1,serine/threonine kinase 11; MTORC1/MTOR complex 1, mechanistic target of rapamycin kinase complex 1; NAE1, NEDD8 activating enzyme E1 subunit 1; NOC, nocodazole; RING, really interesting new gene; RBX1, ring-box 1; SA-GLB1/β-gal, senescence-associated galactosidase beta 1; TSC2, TSC complex subunit 2; TUBA, tubulin alpha; WIPI2, WD repeat domain, phosphoinositide interacting 2
The gas-to-dust mass ratio of Centaurus A as seen by Herschel
Creators: name: Parkin, T. J.
name: Wilson, C. D.
name: Foyle, K.
name: Baes, M.
name: Bendo, G. J.
name: Boselli, A.
name: Boquien, M.
name: Cooray, A.
name: Cormier, D.
name: Davies, J. I.
name: Eales, S. A.
name: Galametz, M.
name: Gomez, H. L.
name: Lebouteiller, V.
name: Madden, S.
name: Mentuch, E.
name: Page, M. J.
name: Pohlen, M.
name: Remy, A.
name: Roussel, H.
name: Sauvage, M.
name: Smith, M. W. L.
name: Spinoglio, L.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present photometry of the nearby galaxy NGC 5128 (Centaurus A) observed with the PACS and SPIRE instruments on board the Herschel Space Observatory, at 70, 160, 250, 350 and 500 μm, as well as new CO J = 3-2 observations taken with the HARP-B instrument on the JCMT. Using a single component modified blackbody, we model the dust spectral energy distribution within the disk of the galaxy using all five Herschel wavebands, and find dust temperatures of ~30 K towards the centre of the disk and a smoothly decreasing trend to ~20 K with increasing radius. We find a total dust mass of (1.59 \pm 0.05) \times 10^7 M\odot, and a total gas mass of (2.7 \pm 0.2) \times 10^9 M\odot. The average gas-to-dust mass ratio is 103 \pm 8 but we find an interesting increase in this ratio to approximately 275 toward the centre of Cen A. We discuss several possible physical processes that may be causing this effect, including dust sputtering, jet entrainment and systematic variables such as the XCO factor. Dust sputtering by X-rays originating in the AGN or the removal of dust by the jets are our most favoured explanations.
description: Accepted for publication in MNRAS; 11 pages, 8 figures, 1 table
First stars in Damped Lyman Alpha systems
Creators: name: Salvadori, Stefania
name: Ferrara, Andrea
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In order to characterize Damped Lyman Alpha systems (DLAs) potentially hosting first stars, we present a novel approach to investigate DLAs in the context of Milky Way (MW) formation, along with their connection with the most metal-poor stars and local dwarf spheroidal (dSph) galaxies. The merger tree method previously developed is extended to include inhomogeneous reionization and metal mixing, and it is validated by matching both the Metallicity Distribution Function of Galactic halo stars and the Fe-Luminosity relation of dSph galaxies. The model explains the observed NHI-Fe relation of DLAs along with the chemical abundances of [Fe/H] < -2 systems. In this picture, the recently discovered z_abs ~ 2.34 C-enhanced DLA (Cooke et al. 2011a), pertains to a new class of absorbers hosting first stars along with second-generation long-living low-mass stars. These "PopIII DLAs" are the descendants of H2-cooling minihalos with Mh ~ 10^7 Msun, that virialize at z > 8 in neutral, primordial regions of the MW environment and passively evolve after a short initial period of star formation. The gas in these systems is warm Tg \sim (40-1000) K, and strongly C-enriched by long-living, extremely metal-poor stars of total mass M* \sim 10^{2-4} Msun.
description: 5 pages, 4 figures, accepted for publication in MNRAS letter
Proof of a conjecture by Gazeau et al. using the Gould Hopper polynomials
Creators: name: Vignat, C.
name: Lévêque, O.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We prove the "strong conjecture" expressed by Gazeau et al. in arXiv:1203.3936v1 [math-ph] about the coefficients of the Taylor expansion of the exponential of a polynomial. This implies the "weak conjecture" as a special case. The proof relies mainly about properties of the Gould-Hopper polynomials.
The Trans-Planckian Problem in the Healthy Extension of Horava-Lifshitz Gravity
Creators: name: Ferreira, Elisa G. M.
name: Brandenberger, Robert
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Planck scale physics may influence the evolution of cosmological fluctuations in the early stages of cosmological evolution. Because of the quasi-exponential redshifting, which occurs during an inflationary period, the physical wavelengths of comoving scales that correspond to the present large-scale structure of the Universe were smaller than the Planck length in the early stages of the inflationary period. This trans-Planckian effect was studied before using toy models. The Horava-Lifshitz (HL) theory offers the chance to study this problem in a candidate UV complete theory of gravity. In this paper we study the evolution of cosmological perturbations according to HL gravity assuming that matter gives rise to an inflationary background. As is usually done in inflationary cosmology, we assume that the fluctuations originate in their minimum energy state. In the trans-Planckian region the fluctuations obey a non-linear dispersion relation of Corley-Jacobson type. In the "healthy extension" of HL gravity there is an extra degree of freedom which plays an important role in the UV region but decouples in the IR, and which influences the cosmological perturbations. We find that in spite of these important changes compared to the usual description, the overall scale-invariance of the power spectrum of cosmological perturbations is recovered. However, we obtain oscillations in the spectrum as a function of wavenumber with a relative amplitude of order unity and with an effective frequency which scales nonlinearly with wavenumber. Taking the usual inflationary parameters we find that the frequency of the oscillations is so large as to render the effect difficult to observe.
description: 21 pages, 1 figure, a few references added
Equation of motion of a quantum vortex
Creators: name: Thompson, Lara
Publisher: name: University of British Columbia
Year: 2011

description: Quantum vortices are an important excitation in a wide variety of systems. They are a basic ingredient in our understanding of superfluids and superconductors --- indeed, the very definition of these phases relies heavily on the existence of quantum vortices. Despite this, the equation of motion of a quantum vortex remains controversial. In this thesis, we derive the two dimensional equation of motion of a vortex in superfluid helium, and also discuss adapting our derivation for a vortex in a ferromagnet dot. In addition to the undisputed superfluid Magnus force and vortex inertia, we derive the controversial Iordanskii force, a pair of memory forces, and the associated fluctuating force. The memory forces include a generalization of the usual longitudinal damping force, a frequency dependent inertial force, and a higher order, frequency dependent correction to the Iordanskii force. We quantify the slow limit in which these forces become local or frequency independent. In a superfluid, the motion is frequency dependent, manifest primarily through a suppression of the damping rate of the vortex motion. Magnetic vortex motion is typically at much lower frequencies and the memory effects can so far be ignored. Our analysis involves a careful separation of vortex and quasiparticle degrees of freedom. We prove definitively that there are no interactions that are first order in quasiparticle variables: therefore, all resulting forces on the vortex resulting from interactions with the quasiparticles are temperature-dependent. We calculate the vortex influence functional resulting from a velocity-dependent quadratic coupling with perturbed quasiparticles that have already been perturbed by the presence of the static vortex. From the vortex influence functional and the bare vortex action, we derive the full quantum equation of motion of a vortex. We relate our arguments and results to the wealth of ideas presented in the superfluid and magnetic literature. We discuss extensions of this work: on including normal fluid viscosity, dynamics of a multiple vortex configuration, to a finite system, and to a three-dimensional system.
Low-noise conditional operation of singlet-triplet coupled quantum dot qubits
Creators: name: Yang, Shuo
name: Sarma, S. Das
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically study the influence of charge noise on a controlled phase gate, implemented using two proximal double quantum dots coupled electrostatically. Using the configuration interaction method, we present a full description of the conditional control scheme and quantitatively calculate the gate error arising from charge fluctuations. Our key finding is that the existence of noise-immune sweet spots depends on not only the energy detuning but also the device geometry. The conditions for sweet spots with minimal charge noise are predicted analytically and verified numerically. Going beyond the simple sweet-spot concept we demonstrate the existence of other optimal situations for fast and low-noise singlet-triplet two-qubit gates.
description: 4 pages, 4 figures
CMOS programmable gain circuits: amplifiers and current conveyors
Creators: name: Quan, James
Publisher: name: University of Calgary
Year: 2005

description: Bibliography: p. 117-123
description: CJ\IOS programmable gain stages form essential building blocks i11 today's Lclccom­m1wicat.iou sys Le ms. For each specific application, there may lie a myriad of poLcnt.ial solnt.ious: however, not all soluLiom; are equally suited Lo solving all problems. Sornc problems may be directly treated with traditional voltage-mode approaches while ot.lier problems may lie more efficiently tackled via less convcnLiomt! currcut-modc methods. In view of such an expansive landscape, the present. work seeks Lo investi­gate t.wo telecommunication applications and Lhe specific solnt.iuu for each. FirsLly, a LradiLional Programmable Gain Amplifier (PGA) is clcsig11ccl for 11:-:c ui Very J-1.igh-Spccd Digit.al Suli:-:cribcr Loops (VDSL). Wide lm,ndwidLh, low noi:-:c, aml high Ii neariLy arc achicve
Fast and Exact Top-k Search for Random Walk with Restart
Creators: name: Fujiwara, Yasuhiro
name: Nakatsuji, Makoto
name: Onizuka, Makoto
name: Kitsuregawa, Masaru
Publisher: name: arXiv
Year: 2012
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: Graphs are fundamental data structures and have been employed for centuries to model real-world systems and phenomena. Random walk with restart (RWR) provides a good proximity score between two nodes in a graph, and it has been successfully used in many applications such as automatic image captioning, recommender systems, and link prediction. The goal of this work is to find nodes that have top-k highest proximities for a given node. Previous approaches to this problem find nodes efficiently at the expense of exactness. The main motivation of this paper is to answer, in the affirmative, the question, `Is it possible to improve the search time without sacrificing the exactness?'. Our solution, {it K-dash}, is based on two ideas: (1) It computes the proximity of a selected node efficiently by sparse matrices, and (2) It skips unnecessary proximity computations when searching for the top-k nodes. Theoretical analyses show that K-dash guarantees result exactness. We perform comprehensive experiments to verify the efficiency of K-dash. The results show that K-dash can find top-k nodes significantly faster than the previous approaches while it guarantees exactness.
description: VLDB2012
การเรียนรู้ของชุมชนภายใต้โครงสร้างและปฏิสัมพันธ์ในการสร้างเสริมความมั่นคงทางอาหาร
Creators: name: พรทิพย์ ติลกานันท์
Publisher: name: ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์
Year: 2564
Subjects: การเรียนรู้ของชุมชน
โครงสร้างและปฏิสัมพันธ์ทางสังคม
ความมั่นคงทางอาหาร

description: วารสารครุศาสตร์, 49, 1, EDUCU4901003 (18 หน้า)
ПРОДУКТИВНОСТЬ ПЕРЕПЕЛОВ ЭКСПЕРИМЕНТАЛЬНЫХ СОЧЕТАНИЙ
Creators: name: Рехлецкая Е. К.
name: Дымков А. Б.
Publisher: name: Эффективное животноводство
Year: 2021
Subjects: птицеводство
перепела
порода фараон
порода техасский белый
порода омская
живая масса
мясная продуктивность
экономическая эффективность
рентабельность
poultry farming
quail
Pharaoh breed
Texas white breed
Omsk breed
live weight
meat productivity
economic efficiency
profitability

description: В статье приведена продуктивность перепелов экспериментальных сочетаний. Установлено, что перспективным для создания мясного кросса перепелов может быть скрещивание породы техасский белый в качестве отцовской формы с перепёлками омской в качестве материнской.
description: The article shows the productivity of quails of experimental combinations for the prospect of creating a meat cross of quails. It has been established that the crossing of the Texas White breed as a paternal form with Omsk quails as a maternal form can be promising for creating a meat cross of quails.
Transformation of a Star into a Planet in a Millisecond Pulsar Binary
Creators: name: Bailes, M.
name: Bates, S. D.
name: Bhalerao, V.
name: Bhat, N. D. R.
name: Burgay, M.
name: Burke-Spolaor, S.
name: D'Amico, N.
name: Johnsto, S.
name: Keith, M. J.
name: Kramer, M.
name: Kulkarni, S. R.
name: Levin, L.
name: Lyne, A. G.
name: Milia, S.
name: Possenti, A.
name: Spitler, L.
name: Stappers, B.
name: van Straten, W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Millisecond pulsars are thought to be neutron stars that have been spun-up by accretion of matter from a binary companion. Although most are in binary systems, some 30% are solitary, and their origin is therefore mysterious. PSR J1719-1438, a 5.7 ms pulsar, was detected in a recent survey with the Parkes 64m radio telescope. We show that it is in a binary system with an orbital period of 2.2 h. Its companion's mass is near that of Jupiter, but its minimum density of 23 g cm$^{-3}$ suggests that it may be an ultra-low mass carbon white dwarf. This system may thus have once been an Ultra Compact Low-Mass X-ray Binary, where the companion narrowly avoided complete destruction.
description: 16 pages, 3 figures. Science Express, in press
The Inevitable Universe: Why Existence Happens in Consciousness
Creators: name: Prosperi, Giovanni
Publisher: name: Zenodo
Year: 2025

description: Why does anything exist at all, instead of nothing?

This ancient question has haunted philosophy for centuries. In this rigorous and radical essay, Giovanni Prosperi presents a new metaphysical framework: not a theory, but a logical structure.

Beginning with the impossibility of absolute nothingness, Prosperi unfolds a vision of being as logically necessary, self-generating, and actualized through coherent observation. Consciousness is not a byproduct of matter or a biological accident—it is the structural act through which the universe becomes real.

Drawing from metaphysics, logic, and quantum theory, The Inevitable Universe explores the idea that reality is not “out there” but collapses into form through conscious observation. Being is not a thing, but a process. Observation is not passive, but creative. The universe does not occur—it observes itself.

A poetic and philosophical journey into the deepest foundations of reality, this work is aimed at philosophers, scientists, and all who are willing to follow rational thought to its most daring conclusions.
Atmospheric plasma sources for surface modifications in 3d printed scaffolds
Creators: name: Neubert, Thomas
name: Lachmann, Kristina
name: Thomas, Michael
name: Scopece, Paolo
name: Moroni, Lorenzo
name: Patelli, Alessandro
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2021

description: In this work we investigate the coating of 3D-printed polymer structures with a robotic atmospheric pressure plasma jet with (3-aminopropyl)tri-methoxysilane. In particular, we investigated how deeply the coatings penetrate into the porous polymer structures and whether the nucleophilic groups are preserved. The influence of other process parameters (duty cycle, temperature, angle of the plasma jet to the substrate surface) is also discussed.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021): Trans. AMMM
Design and characterization of AM sensorized capsules for drug delivery devices
Creators: name: Graziano, Marta
name: Charig, David William
name: Di Trani, Nicola
name: Grattoni, Alessandro
name: De Pasquale, Giorgio
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2021

description: Long-acting drug delivery systems able to sustain the release of therapeutics in a controllable manner can provide several advantages in the treatment of chronic diseases. Given the high drug concentration in the reservoir, an inward osmotic fluid transport occurs across the membrane, which counters the outward diffusion of drugs. The resulting osmotic pressure buildup may be sufficient to cause the failure of implants with associated risks to patients. Confidently assessing the osmotic pressure buildup requires testing in vivo. Here, using metal and polymer additive manufacturing processes, we designed and developed implantable drug reservoirs with embedded strain sensors to directly measure the osmotic pressure in drug delivery implants in vitro and in vivo.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021): Trans. AMMM
Constraining the Flaring Region of Sagittarius A* By 1.3mm VLBI Measurements
Creators: name: Huang, Lei
name: Shen, Zhi-Qiang
name: Gao, Feng
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use a model of an accretion flow coupled with an emergent flare to interpret the latest 1.3mm VLBI measurements for Sagittarius A*. The visibility data constrained the distances from the flare center to the black hole center as $d_{\rm EW}\lesssim20{\rm R_g}$ and $d_{\rm NS}\lesssim80{\rm R_g}$ in the East-West and North-South directions, respectively. If interpreted by the hot-spot model, the flare was preferred to pass in front of the black hole at a radius much larger than $d_{\rm EW}$. If interpreted by the episodic jet launched from a nearly edge-on hot accretion flow, the flare was preferred to be ejected with $θ_{\rm j}\gtrsim40^\circ$ off the black hole rotating axis. This method can be generalized to help us understand future sub-millimeter VLBI observations, and study the millimeter/sub-millimeter variabilities in the vicinity of the Galactic Center supermassive black hole.
description: 14 pages, 3 figures, Accepted by ApJ Letter
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation
Creators: name: Lu, Guang
name: Yi, Juan
name: Gubas, Andrea
name: Wang, Ya-Ting
name: Wu, Yihua
name: Ren, Yi
name: Wu, Man
name: Shi, Yin
name: Ouyang, Chenxi
name: Tan, Hayden Weng Siong
name: Wang, Tianru
name: Wang, Liming
name: Yang, Nai-Di
name: Deng, Shuo
name: Xia, Dajing
name: Chen, Ruey-Hwa
name: A. Tooze, Sharon
name: Shen, Han-Ming
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded by lysosome in response to various stress conditions. Apart from its role in the maintenance of cellular homeostasis, autophagy also involves in regulation of cell cycle progression under nutrient-deprivation conditions. However, whether and how autophagy is regulated by the cell cycle especially during mitosis remains largely undefined. Here we show that WIPI2/ATG18B (WD repeat domain, phosphoinositide interacting 2), an autophagy-related (ATG) protein that plays a critical role in autophagosome biogenesis, is a direct substrate of CUL4-RING ubiquitin ligases (CRL4s). Upon mitosis induction, CRL4s are activated via neddylation, and recruit WIPI2 via DDB1 (damage specific DNA binding protein 1), leading to polyubiquitination and proteasomal degradation of WIPI2 and suppression of autophagy. The WIPI2 protein level and autophagy during mitosis could be rescued by knockdown of CRL4s or treatment with MLN4924/Pevonedistat, a selective inhibitor of CRLs, via suppression of NAE1 (NEDD8 activating enzyme E1 subunit 1). Moreover, restoration of WIPI2 rescues autophagy during mitosis and leads to mitotic slippage and cell senescence. Our study thus discovers a novel function of CRL4s in autophagy by targeting WIPI2 for polyubiquitination and proteasomal degradation during mitosis. Abbreviations: ACTB, actin beta; ATG, autophagy-related; AMPK, AMP-activated protein kinase; AURKB/ARK2, aurora kinase B; BafA1, bafilomycin A1; CCNB1, cyclin B1; CDK1, cyclin dependent kinase 1; CHX, cycloheximide; CQ, chloroquine; CRL4s, CUL4-RING ubiquitin ligases; DDB1, damage specific DNA binding protein 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GFP, green fluorescent protein; GST, glutathione S-transferase; MAP1LC3B/LC3B, microtubule associated protein 1 light chain 3 beta; STK11/LKB1,serine/threonine kinase 11; MTORC1/MTOR complex 1, mechanistic target of rapamycin kinase complex 1; NAE1, NEDD8 activating enzyme E1 subunit 1; NOC, nocodazole; RING, really interesting new gene; RBX1, ring-box 1; SA-GLB1/β-gal, senescence-associated galactosidase beta 1; TSC2, TSC complex subunit 2; TUBA, tubulin alpha; WIPI2, WD repeat domain, phosphoinositide interacting 2
3D printing of individualized cranial PEEK implants – saving costs and following regulatory pathways
Creators: name: Herzmann, Martin
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2021

description: This paper describes of a complete workflow to produce individualized cranial implants using additive manufacturing with PEEK filament. The workflow includes design regulations, definitions of part orientation and support generation as well as process parameter definitions and post-processing steps. In addition to technical feasibility, clinical requirements and regulatory pathways are described. The described workflow has the potential to accelerate the distribution of personalized medical care while saving material compared to milling processes. In comparison to milling technologies this manufacturing process has the enormous potential to save raw material. In additive manufacturing about 85% of the material used is used for the implant. Only 10-15% is used for support structures, which are removed in post-processing. However, with conventional manufacturing technologies such as milling, on the other hand, about 10-20% of the material is used as the implant - the rest is wasted that is removed. In addition, the described technology provides for the first time to achieve mechanical properties equivalent to those achieved by milling. Cost savings with filament printing compared to other 3D printing technologies for cranial plate manufacturing will further accelerate the acceptance of patient matched implants. Comparable low initial investments in printer hardware and reduced post-processing requirements make the overall costs shrink in comparison to titanium printing based on powder bed technology. Kumovis workflow makes individualized cranial implants affordable for a broad range of healthcare systems. In addition, it accumulates the clinical benefits of high-performance polymers such as high wearing comfort, patient`s acceptance, millimetre accuracy of fit, optimal biocompatibility and low revision rates.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021): Trans. AMMM
title: MOB : die Bahnlinie Montreux-Oberland Bernois : von Montreux bis Zweisimmen
title: MOB : die Bahnlinie Montreux-Oberland Bernois : von Montreux bis Zweisimmen
titleType: AlternativeTitle
Creators: name: Compagnie Du Chemin De Fer Montreux Oberland Bernois
Publisher: name: MITV Ltd
Year: 1992

description: L'emboîtage porte: eine Fahrt auf einer der atemberaubendsten Strecken der schweizer Bahnen von Montreux bis Zweisimmen auf der berhümten MOB
Static Kerr Green's Function in Closed Form and an Analytic Derivation of the Self-Force for a Static Scalar Charge in Kerr Space-Time
Creators: name: Ottewill, Adrian C.
name: Taylor, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We derive a closed-form solution for the Green's function for the wave equation of a static (with respect to an undragged, static observer at infinity) scalar charge in the Kerr space-time. We employ our solution to obtain an analytic expression for the self-force on such a charge, comparing our results to those previously obtained using the mode-sum regularization prescription.
description: 18 pages, 2 figures
Chrysis gribodoi Abeille de Perrin 1877
Creators: name: Paukkunen, Juho
name: Rosa, Paolo
name: Soon, Villu
name: Johansson, Niklas
name: Ødegaard, Frode
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Masaridae
Chrysis
Chrysis gribodoi

description: 10. Chrysis gribodoi Abeille de Perrin, 1877
Chrysis gribodoi Abeille de Perrin 1877: 66. Syntypes ♀♀; France: La Penne (MNHN) (examined) (Chrysis succincta group).
Remarks. As noted by Vikberg (1986a: 62), the species was added erroneously to the Finnish fauna by Silfverberg (1981: 61), who referred to Hellén (1920). In his review of the Finnish chrysidids Hellén (1920: 212) gave a short description of C. succincta ab. gribodoi Ab., though no locality was given. Later (1935: 8) he mentioned “ab. gribodoi ” in the Finnish checklist of aculeate Hymenoptera. Chrysis gribodoi is a South European species, and it is obvious that the taxon has not been found in Finland.
description: Published as part of Paukkunen, Juho, Rosa, Paolo, Soon, Villu, Johansson, Niklas & Ødegaard, Frode, 2014, Faunistic review of the cuckoo wasps of Fennoscandia, Denmark and the Baltic countries (Hymenoptera: Chrysididae), pp. 1-67 in Zootaxa 3864 (1) on page 52, DOI: 10.11646/zootaxa.3864.1.1, http://zenodo.org/record/4930433
Equivariant neural networks for inverse problems.
Creators: name: Celledoni, Elena
name: Ehrhardt, Matthias J
name: Etmann, Christian
name: Owren, Brynjulf
name: Schönlieb, Carola-Bibiane
name: Sherry, Ferdia
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Neural networks
Image reconstruction
Equivariance
Variational Regularisation

description: In recent years the use of convolutional layers to encode an inductive bias (translational equivariance) in neural networks has proven to be a very fruitful idea. The successes of this approach have motivated a line of research into incorporating other symmetries into deep learning methods, in the form of group equivariant convolutional neural networks. Much of this work has been focused on roto-translational symmetry of R d , but other examples are the scaling symmetry of R d and rotational symmetry of the sphere. In this work, we demonstrate that group equivariant convolutional operations can naturally be incorporated into learned reconstruction methods for inverse problems that are motivated by the variational regularisation approach. Indeed, if the regularisation functional is invariant under a group symmetry, the corresponding proximal operator will satisfy an equivariance property with respect to the same group symmetry. As a result of this observation, we design learned iterative methods in which the proximal operators are modelled as group equivariant convolutional neural networks. We use roto-translationally equivariant operations in the proposed methodology and apply it to the problems of low-dose computerised tomography reconstruction and subsampled magnetic resonance imaging reconstruction. The proposed methodology is demonstrated to improve the reconstruction quality of a learned reconstruction method with a little extra computational cost at training time but without any extra cost at test time.
Discovery of the Isotopes with 11 <= Z <= 19
Creators: name: Thoennessen, M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A total of 194 isotopes with 11 $\le$ Z $\le$ 19 have been identified to date. The discovery of these isotopes which includes the observation of unbound nuclei, is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.
description: to be pubslihed in At. Data Nucl. Data Tables
Stability Regions Around the Components of the Triple System 2001 SN263
Creators: name: Araujo, R. A. N.
name: Winter, O. C.
name: Prado, A. F. B. A.
name: Sukhanov, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The NEAs (Near-Earth Asteroids) are good targets for spatial missions, since they periodically approach the orbit of the Earth. Recently, the NEA (153591) 2001 SN263 was chosen as the target of the ASTER MISSION- First Brazilian Deep Space Mission, planned to be launched in 2015. In February 2008, the radio astronomers from Arecibo-Puerto Rico concluded that (153591) 2001 SN263 is actually a triple system (Nolan et al., 2008). The announcement of the ASTER MISSION has motivated the development of the present work, whose goal is to characterize regions of stability and instability of the triple system (153591) 2001 SN263. The method adopted consisted in dividing the region around the system into four distinct regions. We have performed numerical integrations of systems composed by seven bodies: Sun, Earth, Mars, Jupiter and the three components of the system, and by thousands of particles randomly distributed within the demarcated regions, for the planar and inclined prograde cases. The results are diagrams of semi-major axis versus eccentricity, where it is shown the percentage of particles that survive for each set of initial conditions. The regions where 100% of the particles survive is defined as stable regions. We found that the stable regions are in the neighborhood of Alpha and Beta, and in the external region. It was identified resonant motion of the particles with Beta and Gamma in the internal regions, which lead to instability. For particles with I>45° in the internal region, where I is the inclination with respect to Alpha's equator, there is no stable region, except for the particles placed really close to Alpha. The stability in the external region is not affected by the variation of inclination. We also present a discussion on the long-term stability in the internal region, for the planar and circular cases, with comparisons with the short-term stability.
description: 18 pages, 14 figures, 1 table. Accepted for publication at MNRAS in 2012 April 4
Improved X-ray baggage screening sensitivity with ‘targetless’ search training
Creators: name: Muhl-Richardson, Alex
name: Parker, Maximilian G.
name: Recio, Sergio A.
name: Tortosa-Molina, Maria
name: Daffron, Jennifer L.
name: Davis, Greg J.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Original Article
Visual Search in Real-World and Applied Contexts
Targetless search
X-ray baggage search
Visual search
Target templates
Templates for rejection
Distractor templates

description: Funder: Defence and Security Accelerator; doi: http://dx.doi.org/10.13039/100012339
description: Abstract: When searching for a known target, mental representations of target features, or templates, guide attention towards matching objects and facilitate recognition. When only distractor features are known, distractor templates allow irrelevant objects to be recognised and attention to be shifted away. This is particularly true in X-ray baggage search, a challenging real-world visual search task with implications for public safety, where targets may be unknown, difficult to predict and concealed by an adversary, but distractors are typically benign and easier to identify. In the present study, we draw on basic principles of distractor suppression and rejection to investigate a counterintuitive ‘targetless’ approach to training baggage search. In a simulated X-ray baggage search task, we observed significant benefits to target detection sensitivity (d′) for targetless relative to target-based training, but no effects of performance-contingent rewards or the inclusion of superordinate semantic categories during training. The benefits of targetless search training were most apparent for stimuli involving less spatial overlap (occlusion), which likely represents the difficulty and greater individual variation involved in searching more visually complex images. Together, these results demonstrate the effectiveness of a counterintuitive targetless approach to training target detection in X-ray baggage search, based on basic principles of distractor suppression and rejection, with potential for use as a real-world training tool.
Worldwide surveillance of self-reported sitting time: a scoping review
Creators: name: Mclaughlin, M.
name: Atkin, A. J.
name: Starr, L.
name: Hall, A.
name: Wolfenden, L.
name: Sutherland, R.
name: Wiggers, J.
name: Ramirez, A.
name: Hallal, P.
name: Pratt, M.
name: Lynch, B. M.
name: Wijndaele, K.
name: Adli, Saiful
name: Gardiner, Paul A.
name: Doyle, Ciaran B.
name: Meadows, Angela
name: Mabry, Ruth M.
name: Pregonero, Alberto Florez
name: Sadarangani, Kabir P.
name: Hadgraft, Nyssa T.
name: Boyle, Terry
name: Farias, Nicolas Aguilar
name: Mair, Jacqueline L.
name: Hafoka, Siosaia F.
name: Mielke, Gregore Iven
name: Lin, Selina Khoo Phaik
name: McLeod, Vienna R.
name: Ranasinghe, Chathuranga
name: Storning, Paul C.
name: Dohrn, Ing-Mari
name: Müller-Riemenschnieder, Falk
name: Al Subhi, Lyutha
name: Yee, Anne Chu Hin
name: Gad, Mayuri
name: Marques, Adilson
name: Kontostoli, Elli
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Review
Sitting time
Sedentary behaviour
Surveillance

description: Abstract: Background: Prolonged sitting time is a risk factor for chronic disease, yet recent global surveillance is not well described. The aims were to clarify: (i) the countries that have collected country-level data on self-reported sitting time; (ii) the single-item tools used to collect these data; and (iii) the duration of sitting time reported across low- to high-income countries. Methods: Country-level data collected within the last 10 years using single-item self-report were included. The six-stage methodology: (1) reviewing Global Observatory for Physical Activity! Country Cards; (2–4) country-specific searches of PubMed, the Demographic and Health Survey website and Google; (5) analysing the Eurobarometer 88.4; and (6) country-specific searches for World Health Organization STEPwise reports. Results: A total of 7641 records were identified and screened for eligibility. Sixty-two countries (29%) reported sitting time representing 47% of the global adult population. The majority of data were from high-income (61%) and middle income (29%) countries. The tools used were the International Physical Activity Questionnaire (IPAQ; n = 34), a modified IPAQ (n = 1) or the Global Physical Activity Questionnaire (GPAQ; n = 27). The median of mean daily sitting times was 4.7 (IQR: 3.5–5.1) hours across all countries. Higher-income countries recorded a longer duration of sitting time than lower-income countries (4.9 vs 2.7 h). Conclusions: This study provides an updated collation of countries collecting self-reported sitting time data. The daily sitting time findings should be interpreted cautiously. Current surveillance of sitting time is limited by a lack of coverage. Measures of population sitting time that are valid, feasible and sensitive to change should be embedded within global surveillance systems, to help guide future policy, research and practice. Trial registration: Not applicable.
Transient photoluminescence enhancement as a probe of the structure of impurity-trapped excitons in CaF$_2$:Yb$^{2+}$
Creators: name: Reid, Michael F.
name: Senanayake, Pubudu S.
name: Wells, Jon-Paul R.
name: Berden, Giel
name: Meijerink, Andries
name: Salkeld, Alexander J.
name: Duan, Chang-Kui
name: Reeves, Roger J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We demonstrate a direct measurement of the energy levels of impurity-trapped excitons in CaF$_2$:Yb$^{2+}$. The radically different radiative decay rates of the lowest exciton state and higher excited states enable the generation of a transient photoluminescence enhancement measured via a two-step excitation process. We observe sharp transitions arising from changes of state of localized electrons, broad bands associated with changes of state of delocalized electrons, and broad bands arising from trap liberation.
description: Minor corrections. arXiv admin note: text overlap with arXiv:1107.4888v2
D4.2 Evaluation Report
Creators: name: Kalypso Iordanou
name: Christodoulou, Eleni
name: Antoniou, Josephina
Publisher: name: De Montfort University
Year: 2020
Subjects: subject: 109999 Technology not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 100599 Communications Technologies not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Twelve Focus Groups with different stakeholders across Europe were pursued in the context of SHERPA’s Evaluation and Validation Strategy (T4.1).
The aim of the focus groups was two fold. Firstly, to gain stakeholders’ views regarding the recommendations that have been developed in the SHERPA project, particularly regarding the set of Guidelines for user and developers (T3.2), the Regulatory Options (T3.3.) and the terms of reference for new regulator (T3.6). Secondly, to obtain an in-depth understanding of stakeholders’ views regarding what they consider as the main ethical issues that come out of Artificial Intelligence (AI) and big data, on the way those ethical issues are currently addressed, and their suggestions on how the ethical issues can be addressed for efficiently in the future.
Kinder- und Jugenddelinquenz im Bundesland Saarland
Creators: name: Baier, Dirk
name: Rabold, Susann
Publisher: name: Universität Tübingen
Year: 2012
Subjects: subject: Kinderkriminalität , Jugendkriminalität , Gewalt , Befragung , Prävention , Saarland
subject: 360

description: Zweitveröffentlichung. Download von https://kfn.de/publikationen/kfn-forschungsberichte
Coordination Cages Selectively Transport Molecular Cargoes Across Liquid Membranes.
Creators: name: Nguyen, Bao-Nguyen T
name: Thoburn, John D
name: Grommet, Angela B
name: Howe, Duncan J
name: Ronson, Tanya K
name: Ryan, Hugh P
name: Bolliger, Jeanne L
name: Nitschke, Jonathan R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021

description: Chemical purifications are critical processes across many industries, requiring 10-15% of humanity's global energy budget. Coordination cages are able to catch and release guest molecules based upon their size and shape, providing a new technological basis for achieving chemical separation. Here, we show that aqueous solutions of FeII4L6 and CoII4L4 cages can be used as liquid membranes. Selective transport of complex hydrocarbons across these membranes enabled the separation of target compounds from mixtures under ambient conditions. The kinetics of cage-mediated cargo transport are governed by guest binding affinity. Using sequential transport across two consecutive membranes, target compounds were isolated from a mixture in a size-selective fashion. The selectivities of both cages thus enabled a two-stage separation process to isolate a single compound from a mixture of physicochemically similar molecules.
Repräsentativbefragung zu Viktimisierungserfahrungen in Deutschland
Creators: name: Hellmann, Deborah F.
Publisher: name: Universität Tübingen
Year: 2014
Subjects: subject: Einbruchdiebstahl , Gewalt , Sexueller Missbrauch , Häusliche Gewalt , Stalking , Sexuelle Gewalt , Prävalenz
subject: 360

description: Zweitveröffentlichung. Download von https://kfn.de/publikationen/kfn-forschungsberichte
Densest Subgraph in Streaming and MapReduce
Creators: name: Bahmani, Bahman
name: Kumar, Ravi
name: Vassilvitskii, Sergei
Publisher: name: arXiv
Year: 2012
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: The problem of finding locally dense components of a graph is an important primitive in data analysis, with wide-ranging applications from community mining to spam detection and the discovery of biological network modules. In this paper we present new algorithms for finding the densest subgraph in the streaming model. For any epsilon>0, our algorithms make O((log n)/log (1+epsilon)) passes over the input and find a subgraph whose density is guaranteed to be within a factor 2(1+epsilon) of the optimum. Our algorithms are also easily parallelizable and we illustrate this by realizing them in the MapReduce model. In addition we perform extensive experimental evaluation on massive real-world graphs showing the performance and scalability of our algorithms in practice.
description: VLDB2012
Gewalt gegen niedersächsische Beamtinnen und Beamte aus dem Einsatz- und Streifendienst: Zum Einfluss von personen-, arbeits- und situationsbezogenen Merkmalen auf das Gewaltopferrisiko
Creators: name: Ellrich, Karoline
name: Baier, Dirk
Publisher: name: Universität Tübingen
Year: 2014
Subjects: subject: Verbrechensopfer , Polizei , Streifendienst , Niedersachsen
subject: 360

description: Zweitveröffentlichung. Download von https://kfn.de/publikationen/kfn-forschungsberichte
D4.2 Evaluation Report
Creators: name: Kalypso Iordanou
name: Antoniou, Josephina
name: Christodoulou, Eleni
Publisher: name: De Montfort University
Year: 2020
Subjects: subject: 109999 Technology not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 100599 Communications Technologies not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Twelve Focus Groups with different stakeholders across Europe were pursued in the context of SHERPA’s Evaluation and Validation Strategy (T4.1).
The aim of the focus groups was two fold. Firstly, to gain stakeholders’ views regarding the recommendations that have been developed in the SHERPA project, particularly regarding the set of Guidelines for user and developers (T3.2), the Regulatory Options (T3.3.) and the terms of reference for new regulator (T3.6). Secondly, to obtain an in-depth understanding of stakeholders’ views regarding what they consider as the main ethical issues that come out of Artificial Intelligence (AI) and big data, on the way those ethical issues are currently addressed, and their suggestions on how the ethical issues can be addressed for efficiently in the future.
Wohnungseinbruch: Tat und Folgen: Ergebnisse einer Betroffenenbefragung in fünf Großstädten
Creators: name: Wollinger, Gina Rosa
name: Dreißigacker, Arne
name: Blauert, Katharina
name: Bartsch, Tillmann
name: Baier, Dirk
Publisher: name: Universität Tübingen
Year: 2014
Subjects: subject: Einbruchdiebstahl , Reaktion , Polizei , Justiz
subject: 360

description: Zweitveröffentlichung. Download von https://kfn.de/publikationen/kfn-forschungsberichte