cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Regulation of neutrophil function by NAMPT
Creators: name: Roberts, Kate
Publisher: name: University of Liverpool Repository
Year: 2013

description: Neutrophils have capacity to cause tissue damage in chronic inflammatory disease. In rheumatoid arthritis (RA) they infiltrate joints, secrete proteases and reactive oxygen species (ROS), and express cytokines. RA neutrophils express NAMPT which is a highly conserved, pleiotropic protein, that catalyses the rate-limiting step of the NAD salvage pathway, but also has cytokine-like activity. NAMPT is elevated in inflammation and exerts pro-inflammatory effects on neutrophils. The aim of this research was to determine the role of NAMPT, as a signalling molecule and as an enzyme, in regulating neutrophil activities of pathological importance. Neutrophils were isolated from the blood of healthy donors and either stimulated with NAMPT or else NAMPT was inhibited (with FK866), in the presence and absence of pro-inflammatory cytokines in vitro. Assays for specific neutrophil functions such as production of ROS, bacterial killing and apoptosis were performed, and expression of cytokines was also examined. Transcriptome sequencing of neutrophils treated with FK866 and TNFα in combination, was carried out to investigate the wider impact of NAMPT inhibition on neutrophil gene expression. NAMPT expression was also examined in control, cytokine treated and RA patient neutrophils. NAMPT had little capacity to prime neutrophils, although it did delay neutrophil apoptosis and stabilise the anti-apoptotic protein Mcl-1. NAMPT inhibition in neutrophils, depleted NAD(P)/H and had effects on neutrophil functions and gene expression. Notably, FK866 decreased ROS production but did not affect the ability of neutrophils to kill bacteria. NAMPT-inhibited neutrophils exhibited decreased activation of signalling pathways and a diminished response to cytokines; transcriptome analysis showed that FK866 decreased TNFα-induced expression of many genes. NAMPT expression was not dynamically regulated in control neutrophils, but in RA patient neutrophils, NAMPT mRNA correlated with TNFα expression in a cohort of patients, and NAMPT protein was elevated in synovial fluid neutrophils compared to those from paired blood. Thus, NAMPT is elevated in activated inflammatory neutrophils and correlates with other markers of inflammation in RA, suggesting that it may be a marker of inflammation in these cells. Also, as a NAD biosynthetic enzyme, NAMPT regulates neutrophil functions and gene products central to RA disease pathology, without affecting bacterial killing capacity. This suggests that inhibition of NAMPT may potentially have the capacity to decrease neutrophil mediated tissue-damage observed in chronic inflammation, without adversely compromising host defence, and thus may be a future treatment option for diseases such as RA.
title: Mathematical models for exploring insecticide resistance in vector mosquitoes
Creators: name: Barbosa, Susana
Publisher: name: University of Liverpool Repository
Year: 2013

description: The emergence and spread of insecticide resistance compromises the control of mosquito borne diseases that are responsible for millions of deaths every year in tropical and subtropical areas. Mathematical modelling is a valuable tool that can be used to explore different aspects of the development and management of insecticide resistance. We have used standard population genetics theory and ecological modelling techniques for developing models to evaluate the spread of resistance in the field. We started by developing a methodology to quantify the strength of selection for resistance occurring in nature. We used data from Mexico on the mosquito Aedes aegypti and a maximum likelihood methodology to estimate the selection and dominance coefficients driving the evolution of resistance in the field. We additionally explored the impact of poor data collection, data that combine information from different locations, and the consequences of selection and dominance coefficients varying over the sampling time period. This analysis highlighted factors highly relevant to field work such as the need for frequent surveillance in discrete sentinel sites. The use of insecticidal bed nets represents the primary tool for the prevention of malaria worldwide. It is of extreme importance to maintain their efficacy against mosquitoes, which has been undermined by the development of insecticide resistance. We assed the contribution of a novel design of bed nets in delaying insecticide resistance while at the same time determining the important parameters in driving resistance in an heterogeneous environment. We showed that this new bed net can indeed contribute to the delay of the spread of resistance, but surprisingly could have the reverse effect in specific circumstances. Finally we developed a model for the vector of malaria, that considers the stage-structured nature of the mosquito life cycle and, most importantly, explicitly incorporates insecticide resistance. It can be used to understand the population dynamics of mosquitoes throughout their entire lifecycle while analysing the impact of vector control interventions, alone and in combination, and the spread of insecticide resistance that those interventions induce. We showed that targeting the larval stages has the greatest effect on the adult population followed by targeting non host-seeking female adults. According to our results, low levels of resistance can induce failure of interventions, and the rate of spread of resistance is faster when insecticides target the larval stages.
title: Criminal Careers of a sub-set of offenders in Barbados
Creators: name: Gittens, Eleanor
Publisher: name: University of Liverpool Repository
Year: 2012

description: The research in this thesis built on several papers that have brought criminal career research to the forefront of the scientific and empirical study of criminal behaviour. However, most existing research has been limited in scope and confined to a relatively small range of samples from more developed, first world, countries; in particular, the USA, the UK, and Canada. The main aim of the present research, therefore, was to replicate and extend previous work on criminal careers using a sample of offenders from a developing nation, Barbados. Given the limitations of previous work, the present research not only examined a number of key variables previously identified in relation to criminal careers (onset age, career length, chronicity, versatility, and seriousness), but also extended the investigation to look at issues surrounding specialisation, violence and demographic factors as related to criminal careers. The sample consisted of 1692 offenders who were charged in Barbados during 2002 and 2006 for robbery and sex offences and during 2006 for drug offences. Several important findings emerged. In particular, there was a significant negative relationship between onset age and the other criminal career variables, the latter of which were positively correlated with each other; this supports the idea of a general factor underlying criminal careers. Nevertheless, there were also variations according to different types of offences. Thus, on average, sex and drug offenders had the shortest career lengths and showed the least versatility and the lowest levels of chronicity and seriousness. In contrast, burglary offenders had the longest career lengths, the earliest age of onset, the greatest versatility, and committed the most serious crimes. In addition, contrary to the findings of some previous studies, there was evidence of specialisation in the sample, and specialists had an earlier age of onset, longer careers, lower versatility and lower levels of crime seriousness than non-specialists. Violent offenders showed a similar pattern of earlier age of onset, longer careers, greater versatility and higher levels of chronicity and seriousness than non-violent offenders. Finally, there were some differences according to gender, race, housing area, employment type and educational level for the key criminal career variables. The results of the research are discussed in terms of their comparability with previous research in the field from more developed nations. Despite some interesting discrepancies, it is argued that, in general, the criminal career findings of the present sample are remarkably similar to previous findings from other countries; however, this could be a feature of the particular historical background of Barbados. Other implications for criminal career research, including practical applications, are also discussed, as well as directions for future research.
title: A systematic analysis of human transmembrane E3-RING proteins
Creators: name: Jenn, Robert
Publisher: name: University of Liverpool Repository
Year: 2012

description: The reversible covalent conjugation of the small highly conserved ubiquitin protein modifier to selective substrates plays central roles in countless proteolytic and non-proteolytic cellular functions. Substrate protein ubiquitination is co-ordinated by the sequential activity of three distinct classes of proteins: (i) E1-activating enzymes, (ii) E2-conjugating enzymes, and (iii) E3-protein ligases. Really Interesting New Gene (RING) proteins represent the largest family of E3-proteins comprising over half of predicted human E3-ligases. As such, E3-RING proteins play pivotal roles in controlling both specificity and functionality within the ubiquitin system. E3-RING proteins function as catalytically inactive molecular scaffolds that position Ub~E2 and substrate proteins in close proximity for ubiquitination to occur. Within the active ligase complex, E3-RING proteins and E2 conjugating enzymes are believed to select protein substrate(s) and the form of conjugated ubiquitin upon them, respectively. Whilst E3-RING/E2 partners have been investigated in recent HTP screen approaches, a key area of data paucity exists for integral membrane E3-RING (TM-E3-RING) proteins. As such, high throughput yeast-two-hybrid assays were performed for the entire complement of TM-E3-RING proteins and E2-conjugating enzymes. A broad subset of TM-E3-RING/E2 positive and negative Y2H interactions was re-tested in secondary luciferase protein complementation assays (PCAs), which increased confidence in Y2H-derived interactions and extended network coverage. Data from these studies was collated with previously published binary TM-E3-RING/E2 interaction data to provide a high-confidence TM-E3-RING/E2 network consisting of 312 unique binary interactions. In vitro auto-ubiquitination assays were employed to assign functional activity to TM-E3-RING/E2 protein pairs, revealing high verification rates for both positive and negative Y2H or PCA binary interaction data. Furthermore, novel trends in the generation of different forms of ubiquitin modifications were identified between selective TM-E3-RING/E2 pairs. Finally, Y2H screens were also performed to identify TM-E3-RING dimerization events, which represent an emerging theme in ubiquitin system regulation. In total 71 TM-E3-RING/TM-E3-RING interactions were reported demonstrating high incidence of these binding events. Novel data was combined with known interactions to generate a TM-E3-RING network containing >500 binary interactions, encompassing both components of the core ubiquitin cascade and non-ubiquitome proteins. This TM-E3-RINGcentric network provides a valuable tool for the investigation of specificity and regulation of TM-E3-RING proteins and specific ubiquitin cascades.
The concept of instrument constituencies: accounting for dynamics and practices of knowing governance
Creators: name: Simons, Arno
name: Voß, Jan-Peter
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: Instrument constituencies
subject: policy instruments
subject: governance
subject: knowledge
subject: agency
subject: policy process
subject: policy-making
subject: practices
subject: 300 Sozialwissenschaften
subject: 330 Wirtschaft

description: This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: As a new concept in policy analysis, instrument constituencies shed light on the ‘supply side’ of policy-making and thereby fill a gap in our understanding of national and transnational policy dynamics. Policy instruments are not only ‘active’ because they contain scripts for reordering society but also because they gather a constituency comprised of practices and actors oriented towards developing, maintaining and expanding a specific instrumental model of governing. Instrument constituencies account for a hitherto neglected form of agency and explain the often-observed paradox that policy solutions sometimes chase policy problems, although the former are meant to emerge as answers to the later. We give an outline of the concept as it has been developed so far, formulate propositions, and discuss linkages with established research traditions in policy studies.
Deliverable D1.1 Initial Data Management Plan
Creators: name: Lawrence, Elizabeth
name: Appeltans, Ward
name: Lepola, Nina
name: Provoost, Pieter
name: Mtwana Nordlund, Lina
Publisher: name: Zenodo
Year: 2024
Subjects: data management plan
Horizon Europe
essential ocean variables

description: The Data Management Plan (DMP) is a mandatory component for Horizon Europe projects and provides guidance on data management for BioEcoOcean partners, particularly in making data FAIR (Findable, Accessible, Interoperable, Reusable). BioEcoOcean aims to co-create a Blueprint for Integrated Ocean Science and advance the technical readiness of Essential Ocean Variables by conducting state-of-the-art research, necessitating alignment with international data standards. BioEcoOcean DMPs (D1.1, D1.2) are deliverables due at months 6 and 24 of the project. This document is the initial version of the DMP and will be reviewed and updated periodically as a living document.
Dolomedes fimbriatus Clerck 1757
Creators: name: Thaler, Konrad
Publisher: name: Zenodo
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Pisauridae
Dolomedes
Dolomedes fimbriatus

description: Dolomedes fimbriatus (Clerck, 1757) (Pisauridae) (Abb. 9-10) Mat.: Piller Sattel1500 m, Moor, 1 cf CTh I. Juni 2003, leg. Meyer. Imst /Tarrenz, Gurgltal830 m, 19 5. Juli20m, leg. Knoflach. Der Fund am Piller Sattel ist der höchste Nachweis dieser großen, an stehende Gewässer gebundenen Jagdspinne im Gebiet (THALER 1997a).
description: Published as part of Konrad Thaler, 2005, Fragmenta Faunistica Tirolensia - XVIII (Arachnida: Araneae; Insecta: Psocoptera, Strepsiptera, Megaloptera, Neuroptera, Raphidioptera, Mecoptera, Siphonaptera, Diptera: Mycetophiloidea), pp. 161-180 in Veröffentlichungen des Tiroler Landesmuseums Ferdinandeum 84 on page 163
title: Alterations of endometrial basement membrane integrity and stem/progenitor cell markers in endometriosis
Creators: name: Palial, Kanchan
Publisher: name: University of Liverpool Repository
Year: 2012

description: Alterations of Endometrial Basement Membrane Integrity and Stem/Progenitor Cell Markers in Endometriosis Palial, K; Drury, J, Heathcote, L, Valentijin, A.J, Gazvani, R, Rudland, P.S. and Hapangama, D.K. Department of Women's and Children's Health, University of Liverpool, Liverpool, United Kingdom, L8 7SS. School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom, L69 7ZB Degradation of basement membrane (BM) is reported to be involved in the metastatic process of cancers, and has been shown to be aberrantly expressed in the benign metastatic disease of endometriosis. Emerging evidence show endometrial stem/progenitor cells are involved in endometrial physiology and in certain endometrial pathological conditions, however markers for these cells are lacking. We tested a panel of stem cell markers including cytokeratin 5/6 (CK5/6) and podocalyxin-like protein (PODXL) and stage specific embryonic antigen 1 (SSEA1) in endometrial tissue. Using immunohistochemistry, we aim to investigate if an alteration of BM integrity is associated with differential expression of these stem cell markers in eutopic endometrium collected from fertile controls, post-menopausal (PM) women and patients with endometriosis and endometrial cancer. 1. In the fertile control group, expression of BM components, Collagen IV and laminin, changed across the menstrual cycle and some of these changes agree with previously reported findings. Expression of stem cell markers SSEA1 and PODXL also showed similar changes across the menstrual cycle with both having maximal expression during the ProlP. Expression of BM components appeared to be correlated with stem cell markers. No cyclical changes in CK5/6 were reported in fertile controls. 2. In the PM group a few differences were seen in BL integrity compared with the fertile control group, especially in BM supporting endometrial vessels. Nonetheless, PODXL and SSEA1 expression was similar to the fertile control group. 3. Complete disruption of BM in the endometrial cancer group provided confirmatory results that BM is disruption in this invasive metastatic disease. 4. In the endometriosis group, differences were seen in the expression of the key BM components in eutopic endometrium sampled from women with endometriosis when compared with fertile controls, and this was similar to previous reported findings. Whereas SSEA1 showed a phase dependent expression in the fertile control group, this was lost in the endometriosis group.
Deliverable D7.2 Project Data Management Plan
Creators: name: Laguionie, Claire
name: Pade, Nicolas
name: Lear, Dan
name: Buttigieg, Pier Luigi
Publisher: name: Zenodo
Year: 2023
Subjects: data management plan
biodiversity data
essential ocean variables
Horizon Europe
Global Ocean Observing System
United Nations Decade of Ocean Science for Sustainable Development

description: The Data Management Plan is a mandatory component of any Horizon Europe project providing information about:
 − Guiding principles around data management following EC Horizon Europe requirements;
 − How to make MBO data FAIR: Findable, Accessible, Interoperable and Re-usable;
 − Data management cost and allocation of resources;
 − Data security and ethics, and confidentiality.
 MARCO-BOLO is a project built around data with the objective to make transformative change in the use of biodiversity data in decision making. Therefore MBO aims to deliver a globally relevant freshwater and marine biodiversity Data Management Plan defined with a Community of Practice of stakeholders from different sectors (industry, policy, research, society) and from different ends of the data pathway (data collector to data end-users). MBO co-design Data Management Plans (D1.1 and D1.2) are deliverables due at 24 and 36 month of the project. The present first iteration of the Data Management Plan is only an overview of MBO principles about freshwater and marine biodiversity data that will be refined and detailed in D1.1 and D1.2.
 The DMP is a live document that will be reviewed and updated periodically.
Towards exact relativistic theory of Earth's geoid undulation
Creators: name: Kopeikin, Sergei
name: Mazurova, Elena
name: Karpik, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The present paper extends the Newtonian concept of the geoid in classic geodesy towards the realm of general relativity by utilizing the covariant geometric methods of the perturbation theory of curved manifolds. It yields a covariant definition of the anomalous (disturbing) gravity potential and formulate differential equation for it in the form of a covariant Laplace equation. The paper also derives the Bruns equation for calculation of geoid's height with full account for relativistic effects beyond the Newtonian approximation. A brief discussion of the relativistic Bruns formula is provided.
description: 14 pages, no figures, several typos in equations, footnotes and bibliography were found and fixed
Steatoda triangulosa Walckenaer 1802
Creators: name: Thaler, Konrad
Publisher: name: Zenodo
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Theridiidae
Steatoda
Steatoda triangulosa

description: Steatoda triangulosa (Walckenaer, 1802) (Theridiidae) Mat.:Innsbruck, Innenstadt, Stiegenhaus, 1 cf CTh Okt. 2003; Dachboden, 19 CTh 9. Juni 2004, leg. BaUini.Mühlau, Hausfassade, I 9 CTh Sept. 2004. Von dieser in Südeuropa häufigen, im Gefolge des Menschen kosmopolitischen Art wurden bisher aus Österreich nur wenige synanthrope / urbane Streufunde bekannt (KNOFLACH & THALER 1998). Für Nordtirolliegt erst eine Meldung aus dem äußeren Ötztal ohne nähere Habitatangabe vor, von Sautens (KRITSCHER 1955). Diese ist ohne Wiederholung geblieben, dürfte aber ein (erloschenes?) Auftreten im Freiland anzeigen. Fundbereich ist ja das Wärmegebiet des äußeren Ötztales. Der um die Mitte des 20. Jahrhunderts ausgeprägt dörfliche Charakter von Sautens macht die Annahme einer Einschleppung wenig wahrscheinlich (JANETSCHEK 1960, THALER 1993, KNOFLACH & THALER 1994).
description: Published as part of Konrad Thaler, 2005, Fragmenta Faunistica Tirolensia - XVIII (Arachnida: Araneae; Insecta: Psocoptera, Strepsiptera, Megaloptera, Neuroptera, Raphidioptera, Mecoptera, Siphonaptera, Diptera: Mycetophiloidea), pp. 161-180 in Veröffentlichungen des Tiroler Landesmuseums Ferdinandeum 84 on page 163
Central Charge and Entangled Gauge Fields
Creators: name: Huang, Kuo-Wei
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Entanglement entropy of gauge fields is calculated using the partition function in curved spacetime with a boundary. We derive a Gibbons-Hawking-like term from a Becchi-Rouet-Stora-Tyutin (BRST) action and a Wald-entropy-like codimension-2 surface term is produced. It is further suggested that boundary degrees of freedom localized on the entanglement surface generated from the gauge redundancy could be used to resolve a subtle mismatch in a universal conformal anomaly- entanglement entropy relation.
description: 8 pages. v5: boundary term corrected with improved notation, minor improvements. More references added
Synergy of Green Energy Technologies through Critical Materials  Circularity
Creators: name: Rahimpour Golroudbary, Saeed
name: Lundström, Mari
name: Wilson, Benjamin P
Publisher: name: Zenodo
Year: 2023

description: Supplementary Information 
Synergy of Green Energy Technologies through Critical Materials Circularity
Saeed Rahimpour Golroudbary, Mari Lundström, Benjamin P Wilson
Hydrometallurgy and Corrosion, Circular Raw Materials Hub, Department of Chemical and Metallurgical Engineering (CMET), School of Chemical Engineering, Aalto University, P.O. Box 16200, Espoo, Finland
title: Code and Data for article "Establishing large mammal population trends from heterogeneous count data"
title: complete code and data for published article
titleType: Subtitle
Creators: name: Pradel, Roger
name: Renaud, Pierre-Cyril
name: Pays, Olivier
name: Scholte, Paul
name: Ogutu, Joseph O
name: Hibert, Fabrice
name: Casajus, Nicolas
name: MIALHE, François
name: Fritz, Hervé
Publisher: name: Zenodo
Year: 2024

description: This zip file contains the code and data used in the article entitled "Establishing large mammal population trends from heterogeneous count data".

Ecology and Evolution. 2024;14:e70193.https://doi.org/10.1002/ece3.70193

There are two main R files, located in the root directory :

estimate_countratio.RexamplesMEEpaper.R

They execute all the calculations in the article. 

After unzipping the file while maintaining the directory structure, the R code will use the data sets in the subdirectory data, and produce outputs in the subdirectory output.

some remarks:

Figure B2 is made from random subsamples and will consequently not produce the exact same output as in the article.

When building Figure B1, inappropriate initial values may cause Jags to crash. In which case, the code may have to be run again.
Simply connected sets
Creators: name: Basye, Robert Eugene
Publisher: name: The University of Texas at Austin
Year: 1933
Subjects: subject: Simply connected
subject: Connected sets
subject: Separation properties
subject: Simple connectedness
subject: Plane continua
subject: Set properties
subject: Topological definition
subject: Set theory
subject: Topological spaces

description: We shall attempt to construct a topological definition of simply connected which is applicable to any connected set. The formulation is made in terms of separation properties intrinsic to the set. In order that a connected and locally arcwise connected subset M of the plane be simply connected under the proposed definition, it is necessary and sufficient that the interior of every simple closed curve lying in M be a subset of M. The notion of simple connectedness in the weak sense is also defined. This property is possessed by every compact plane continuum which does not separate the plane, and by certain continua which do separate the plane. The properties of simply connected sets seem to have a variety of applications, and to furnish an interesting background for a number of well known theorems
Bürokratie und Spiel. Computerspiele zwischen Entscheidbarkeit und (Selbst‑)Verwaltung
Creators: name: Pčelarov, Teodor
Publisher: name: Zenodo
Year: 2023
Subjects: computer
bureau
bureaucracy
games
computer games
gaming
gamification
media
medium
media theory
philosophy
analysis
the stanley parable
stanley parable
interactive
interactivity
büro
bürokratie
spiel
spielen
spiele
computerspiele
interaktivität
medientheorie
medienphilosophie
philosophie
entscheidung
verwaltung
management
administration
berechnung
berechenbarkeit
selbsttechnologie
ästhetik
kinetik
logik

description: Computer und Büros haben vor allem eines gemeinsam: Berechenbarkeit. Geschichtlich geht die Bürokratie zwar der Kybernetik (und damit auch der Computerisierung) vorher, allerdings wurzeln beide – seinsgeschichtlich – in der Verwaltung und Bestellung von Menschen und Dingen.
Wie können Computerspiele vor diesem Hintergrund verstanden werden? Welche Kinästhet(h)iken und Logiken werden im Spielvollzug erfahren?
Code and Data for article "Establishing large mammal population trends from heterogeneous count data"
Creators: name: Pradel, Roger
name: Renaud, Pierre-Cyril
name: Pays, Olivier
name: Scholte, Paul
name: Ogutu, Joseph O
name: Hibert, Fabrice
name: Casajus, Nicolas
name: MIALHE, François
name: Fritz, Hervé
Publisher: name: Zenodo
Year: 2024

description: This zip file contains the code and data used in the article entitled "Establishing large mammal population trends from heterogeneous count data".

There are two main R files, located in the root directory :

estimate_countratio.RexamplesMEEpaper.R

They execute all the calculations in the article. 

After unzipping the file while maintaining the directory structure, the R code will use the data sets in the subdirectory data, and produce outputs in the subdirectory output.

Due to restricted access to some data, the data are not directly available but will be sent on demand, with a confidentiality clause. When received, it should be copied in the subdirectory data prior to executing the code.
title: The role of metastasis inducing proteins in endometrial cancer
Creators: name: Raju, Riya Susan
Publisher: name: University of Liverpool Repository
Year: 2012

description: INTRODUCTION Prognosis of women who develop advanced endometrial cancer is poor, with a 5 year survival rate of only 45% and 25% for stages III and IV respectively. Distant metastasis of malignant endometrial cells beyond the primary focus contributes to the advanced disease stages. A group of proteins, known as metastasis-inducing proteins (MIPs), have been shown to induce cellular invasion and metastasis, specifically AGR2, S100A4, S100P and Osteopontin (OPN). METHODS To investigate the expression of these four MIPs in endometrial cancer, and compare it to the endometrium of fertile control and postmenopausal women. Endometrial samples were collected from 55 women; 30 with endometrial cancer, 15 normal fertile control endometrium in the proliferative phase of the cycle and 10 postmenopausal. The expression of MIPs was evaluated by immunohistochemistry and confirmatory testing was undertaken with reverse transcriptase PCR. RESULTS All endometrial cancer samples showed a significantly increased immuno-reactivity to S100P (Stromal, p = 0.0221) and S100A4 (Stromal, p = 0.0275) compared to benign endometrium. However OPN was virtually absent (Glands p = 0.0047, luminal epithelium p=0.0018) in endometrial cancer cells. All postmenopausal samples showed a significantly decreased immuno-reactivity to all the MIPs (OPN, p = 0.0001, S100P, p = 0.0002, AGR2, p > 0.0001, S100A4, p = 0.0004) compared to endometrial cancer cells. RT-PCR results confirmed IHC results for the expression of S100P, AGR2 and S100A4, but contradicted OPN IHC results. The RT-PCR results gained were not statistically significant. DISCUSSION This data provides an interesting insight into the metastatic process of endometrial cancer. My results suggest that all four MIPs play a key role in metastasis of endometrial cancer, in comparison to the normal postmenopausal endometrium. Further research is required to understand the extent of the involvement OPN, S100P, AGR2 and S100A4 in inducing the metastatic process.
title: The role of political, socio-economic factors and the media in Nigeria's inter-religious conflict
Creators: name: Musa, Aliyu
Publisher: name: University of Liverpool Repository
Year: 2012

description: This study is about the coverage of religious conflict in Nigerian newspapers. Although it was not originally intended to compare the coverage of the conflicts between papers in the North and those in the South of Nigeria, the perceived differential situations of the media in the two regions necessitated such a comparison. It is a qualitative research project consisting of three studies: First, there was a comparative critical examination, through critical discourse analysis, of the reports by two newspapers, THISDAY and Daily Trust, during the November 2008 religious violence in Jos, a central Nigerian city. Second, by means of interpretative phenomenological analysis interview data obtained through the semi-structured technique from Nigeria were critically analysed. Third, also applying interpretative phenomenological analysis data obtained by means of focus group interviewing from Nigeria were critically analysed. The results in all three cases suggest the newspapers are regionally, ethnically and religiously inclined; they are particularly affected by factors like ownership, location, staffing and audience perception, which determine how they tailor reports; the newspapers are not usually the cause of religious crises but they stoke the problem through biased and sometimes inflammatory reports; and, although, they are very vibrant factors like Nigeria’s economic recession, political culture – arguably comprising of violence, corruption and tribalism – and new media/technology and so on, contribute towards making their role in the conflicts one of amplification rather than mitigation. The thesis also suggests the application of Allport’s (1954) contact hypothesis using the media as a conduit towards de-emphasising dissimilarities, while emphasising similarities to reduce tension and prevent conflict.
title: Effects of calcitriol on the crosstalk between macrophages and human adipocytes
Creators: name: Ding, Cherlyn
Publisher: name: University of Liverpool Repository
Year: 2012

description: Macrophage-infiltration of adipocytes in obesity provides an important mechanistic link that may explain the increase in inflammatory mediators produced by adipose tissue. Elucidating the crosstalk mechanisms between macrophages and adipocytes is important as adipose tissue has been shown to be the linchpin linking inflammation and insulin resistance. Growing evidence suggests that vitamin D exerts immunomodulatory effects and adipose tissue could be a target for its action. This study investigated the role of vitamin D3 (calcitriol) in alleviating inflammation mediators expressed and released by human adipocytes under the basal and stimulated conditions. The study also examined the effect of calcitriol on monocyte migration as well as on the NF-κB and MAPK signalling pathways. A simulated model of adipocyte inflammation was created by incubating adipocytes with macrophage-conditioned (MC) medium, and this model was then used to study the effect of vitamin D. High dose calcitriol (10-8M) decreased the basal levels of MCP-1 and IL-6 released by adipocytes. Pretreatment with calcitriol (10-8M) reduced the rise in protein levels of MCP-1 and IL-6 released by adipocytes after stimulation with MC medium. Calcitriol (10-8M) also decreased IL-6 release but it had no effect on MCP-1 production by adipocytes stimulated with TNF-α. Upon MC medium stimulation, calcitriol (10-8M) partially reversed the decrease in gene expression of adiponectin and ZAG although the release of adiponectin or ZAG by adipocytes was unaffected. In addition, calcitriol (10-11M and 10-8M) supplementation decreased THP-1 macrophage migration although it did not reverse the effects of MC medium or TNF-α. Furthermore, calcitriol increased the basal protein abundance of NF-κB IκBα and reversed the inhibitory effect of MC medium on IκBα. Calcitriol supplementation also decreased both basal and MC medium stimulated protein abundance of phosphorylated NF-κB p65 as well as basal and MC medium stimulated levels of phosphorylated p38 MAPK. In conclusion, this study has shown that MC medium potently stimulated inflammatory responses in human adipocytes. Calcitriol supplementation was able to reduce the basal and stimulated production of the proinflammatory mediators by adipocytes. Calcitriol also led to a decrease in chemoattractant ability of adipocytes. In addition, calcitriol exhibited an inhibitory effect on the activation of the NF-κB and MAPK signalling pathways. These results suggest that calcitriol may have a beneficial effect in protecting against adipose tissue inflammation induced by the crosstalk between macrophages and adipocytes.
Annual Report of the Bank of Japan (1909)
Creators: name: Schiltz, Michael
Publisher: name: figshare
Year: 2019
Subjects: subject: 140203 Economic History
subject: FOS: Economics and business
subject: 140101 History of Economic Thought

description: Annual Report of the Bank of Japan for the year 1909. The Report contains the Bank's official viewpoint on the economic conditions of the country, as well as the 'financial operations in the year under review'. It details elements as the bank rate, inflation etc. A most important aspect is its treatment of the outflow and inflow of specie, as the latter was tightly bound up with the country's management of the recently adopted goldstandard (1897).Every report includes an appendix detailing total operations, bank notes issued, the discount of commercial bills, the rate of discount, loans ans their rates of interest, ..., transactions in precious metals.
title: Popular music, identity and musical agency in U.S. youth films
Creators: name: McNelis, Timothy
Publisher: name: University of Liverpool Repository
Year: 2011

description: Popular music is immensely important to the construction of identity and regulation of agency for teenagers in films and in the real world. Throughout this thesis, I shall argue that music, specifically pre-existing songs, constructs identity in a manner that is complex, fluid, and unfixed. This is especially true for teenagers, who are in such a transitional period of their lives. Film music draws on ideas circulating in popular culture to construct identity, and connotations connected with discourse around certain genres of music are of particular importance. Throughout three case study chapters, I shall discuss the cultural context of various songs and genres to suggest possible elements of identity that are available for perceivers to understand. I will be grouping films together in case study chapters based on three narrative threads: teenage girls who play guitars, white characters who use African American music to express identity and improve agency, and non-white characters whose ethnic identity is musically constructed in contradictory ways. Identity and agency are tightly entwined in filmic narratives, and music plays a key role in the construction of both. Musical agency is related to narrative agency, but it also involves characters’ access to musical performance, as well as their musical representation through source music, source score, and dramatic score. The characters with the most musical agency are those who use music to their own benefit or benefit from music in the soundtrack. Finally, I shall argue that musical agency is affected by a film’s internal contradictions – by which I mean the areas of tension between music, identity, and storyline. Characters tend to have the greatest musical agency in films where musical connotations align with other elements of character identity and the character’s treatment in the storyline. Thus, musical agency tends to be less when there are contradictions between characters’ musical performance, the music they listen to, music on the soundtrack (source music, source score, or dramatic score) that they do not choose, other elements of their identity, and their narrative behaviour unrelated to music.
fast-resolve: Fast Bayesian Radio Interferometric Imaging
Creators: name: Roth, Jakob
name: Frank, Philipp
name: Bester, Hertzog Landman
name: Smirnov, Oleg M.
name: Westermann, Rüdiger
name: Enßlin, Torsten
Publisher: name: Zenodo
Year: 2024

description: Reconstruction results of fast-resolve from the publication  "fast-resolve: Fast Bayesian Radio Interferometric Imaging". All files are in the fits format and have flux units of mJy/arcsec^2. 

In the paper "fast-resolve: Fast Bayesian Radio Interferometric Imaging'', snapshots of the reconstruction of the VLA Cygnus~A S-band data are discussed to analyze the convergence speed of resolve and fast-resolve. For completeness, this archive also includes plots of snapshots of the reconstruction of the C, X, and Ku-band data.
Annual Report of the Bank of Japan (1910)
Creators: name: Schiltz, Michael
Publisher: name: figshare
Year: 2019
Subjects: subject: 140203 Economic History
subject: FOS: Economics and business
subject: 140101 History of Economic Thought

description: Annual Report of the Bank of Japan for the year 1910. The Report contains the Bank's official viewpoint on the economic conditions of the country, as well as the 'financial operations in the year under review'. It details elements as the bank rate, inflation etc. A most important aspect is its treatment of the outflow and inflow of specie, as the latter was tightly bound up with the country's management of the recently adopted goldstandard (1897).Every report includes an appendix detailing total operations, bank notes issued, the discount of commercial bills, the rate of discount, loans ans their rates of interest, ..., transactions in precious metals.
MPEC 2023-P02 : 2020 FG15
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Global patterns of genetic diversity and geographical distribution in the marine protist morphospecies Oxyrrhis marina
Creators: name: Martin, Laura E
Publisher: name: University of Liverpool Repository
Year: 2012

description: Species’ diversity and the related processes that drive it are fundamental to understanding patterns of biodiversity. There is a wealth of literature that quantifies the ranges of “large” organisms, and hence our understanding of the processes that determine macrospecies’ distributions; by contrast, this is obviously a more challenging field for microorganisms, of which protists seem to be least studied. Despite this, there are two long debated views regarding protist distribution, proposing that protists display either ubiquity or moderate endemicity. Oxyrrhis marina is an ecologically important marine protist that is used widely as a model organism, and from the pattern of genetic divergence, likely consists of two species. However, patterns of diversity and the distribution of different species (or genetic lineages) are unknown on a global scale. In this thesis I use Oxyrrhis as a model protist to quantify the amount of genetic diversity that may exist between regions at a global scale and to determine whether there are any patterns between genetic diversity and geography. First, I assess current levels of diversity within the O. marina morphospecies. Morphological and molecular literature on O. marina was reviewed and the genus subsequently split into two species: Oxyrrhis marina and Oxyrrhis maritima. Second, genetic divergence between global samples of the Oxyrrhis genus was quantified using multiple gene phylogenies to determine levels of diversity and global patterns of distribution. The three genes COI (mitochondrial), 5.8S ITS and α-tubulin (nuclear) defined the two distinct lineages (O. marina and O. maritima); moreover, 5.8S ITS and α-tubulin uncovered further genetic diversity in strains that were predominantly from East Asian waters. The divergence between these strains and both O. marina and O. maritima is such that they may represent a new species, but further morphological and phylogenetic characterisation is required to support this. The lineages displayed contrasting patterns of distribution and abundance, one being broadly distributed and abundant and the other being geographically restricted and rare in comparison, seemingly supporting both sides of the protist distribution debate. These patterns were not exclusive (i.e. they overlapped) and require further sampling to draw more precise conclusions about the processes that led to their present distributions. This thesis has uncovered high levels of genetic diversity and contrasting distribution patterns displayed in a single genus; it is therefore clearly unrealistic to make generalisations about “protist biogeography” as they display a wide range of responses and distributions.
Optimal quantum tomography with constrained elementary measurements arising from unitary bases
Creators: name: Chaturvedi, S.
name: Ghosh, Sibasish
name: Parthasarathy, K. R.
name: Singh, Ajit Iqbal
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The purpose of this paper is to introduce techniques of obtaining optimal ways to determine a d-level quantum state or distinguish such states. It entails designing constrained elementary measurements extracted from maximal abelian subsets of a unitary basis U for the operator algebra B(H) of a Hilbert space H of finite dimension d > 3 or, after choosing an orthonormal basis for H, for the *-algebra Md of complex matrices of order d > 3. Illustrations are given for the techniques. It is shown that the Schwinger basis U of unitary operators can give for d, a product of primes p and a, the ideal number d^2 of rank one projectors that have a few quantum mechanical overlaps (or, for that matter, a few angles between the corresponding unit vectors). We also give a combination of the tensor product and constrained elementary measurement techniques to deal with all d. A comparison is drawn for different forms of unitary bases for the Hilbert space and also for different Hilbert space factors of the tensor product. In the process we also study the equivalence relation on unitary bases defined by R. F. Werner [J. Phys. A: Math. Gen. 34 (2001) 7081], connect it to local operations on maximally entangled vectors bases, find an invariant for equivalence classes in terms of certain commuting systems, called fan representations, and, relate it to mutually unbiased bases and Hadamard matrices. Illustrations are given in the context of latin squares and projective representations as well.
description: 83 pages, Latex; 17 Figures; Typographical errors corrected and typesetting changed to reduce the file size of the previous version (v3), which was much extended version of the original version (v1); Overlap with arXiv:1401.0099, whose results have already been merged with v3 of the present work; Accepted for publication in Reviews in Mathematical Physics
Finite convergent presentation of plactic monoid for type C
Creators: name: Hage, Nohra
Publisher: name: arXiv
Year: 2014
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We give an explicit presentation for the plactic monoid for type C using admissible column generators. Thanks to the combinatorial properties of symplectic tableaux, we prove that this presentation is finite and convergent. We obtain as a corollary that plactic monoids for type C satisfy homological finiteness properties.
title: Dr. iur., Dr. phil. h.c. Hans E. Mayenfisch
title: Hans E. Mayenfisch
titleType: AlternativeTitle
title: Dr. Hans E. Mayenfisch
titleType: AlternativeTitle
title: geboren am 14. April 1882, gestorben am 11. Januar 1957
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Zentralbibliothek Zürich
Year: 1957
Subjects: subject: 330 Wirtschaft
subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Mayenfisch, Hans E.
subject: Zürich

description: Enthält: Biographische Notizen aus der Ansprache von Herrn Pfarrer Karl Zimmermann; Ansprache von Herrn Walter J. Bär; Ansprache von Herrn Dr. Hans Gwalter, Verwaltungsrats-Präsident der Maschinenfabrik Rüti ZH; Ansprache von Herrn Dr. Franz Meyer, Präsident der Zürcher Kunstgesellschaft; Ansprache von Herrn Prof. emer. Dr. H. v. Meyenburg; Nachruf von Herrn Dr. René Wehrli, Direktor des Kunsthauses Zürich in der «Neuen Zürcher Zeitung» vom 15. Januar 1957; Dr. Hans E. Mayenfisch zum Gedächtnis von Ernst Morgenthaler
A quantitative Carleman estimate for second order elliptic operators
Creators: name: Nakić, Ivica
name: Rose, Christian
name: Tautenhahn, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35J15, 35B60, 35B45

description: We prove a Carleman estimate for elliptic second order partial differential operators with Lipschitz continuous coefficients. The Carleman estimate is valid for any complex-valued function $u\in W^{2,2}$ with support in a punctured ball of arbitrary radius. The novelty of this Carleman estimate is that we establish an explicit dependence on the Lipschitz and ellipticity constants, the dimension of the space and the radius of the ball. In particular we provide a uniform and quantitative bound on the weight function for a class of elliptic operators given explicitly in terms of ellipticity and Lipschitz constant.
description: 23 pages