cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques
Creators: name: Sk. Abdul Amin
name: Sonam Bhargava
name: Nilanjan Adhikari
name: Shovanlal Gayen
name: Jha, Tarun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Phosphodiesterase 1 (PDE1) is a potential target for a number of neurodegenerative disorders such as Schizophrenia, Parkinson’s and Alzheimer’s diseases. A number of pyrazolo[3,4-d]pyrimidine PDE1 inhibitors were subjected to different molecular modelling techniques [such as regression-based quantitative structure-activity relationship (QSAR): multiple linear regression, support vector machine and artificial neural network; classification-based QSAR: Bayesian modelling and Recursive partitioning; Monte Carlo based QSAR; Open3DQSAR; pharmacophore mapping and molecular docking analyses] to get a detailed knowledge about the physicochemical and structural requirements for higher inhibitory activity. The planarity of the pyrimidinone ring plays an important role for PDE1 inhibition. The N-methylated function at the 5th position of the pyrazolo[3,4-d]pyrimidine core is required for interacting with the PDE1 enzyme. The cyclopentyl ring fused with the parent scaffold is necessary for PDE1 binding potency. The phenylamino substitution at 3rd position is crucial for PDE1 inhibition. The N2-substitution at the pyrazole moiety is important for PDE1 inhibition compared to the N1-substituted analogues. Moreover, the p-substituted benzyl side chain at N2-position helps to enhance the PDE1 inhibitory profile. Depending on these observations, some new molecules are predicted that may possess better PDE1 inhibition.
title: OFROM: interview avec ilcf21a32
Creators: name: Delafontaine, François
name: Cam, Aurélie Le
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.cf25g323.v2#55f7c77bff316bc0aae98e440a4036531c46fe76
Associazione di mutuo soccorso fra i docenti ticinesi. Statuto organico riformato il 22 settembre 1878
Creators: name: (:Unkn) Unknown
Publisher: name: Lugano
Year: 1878
Subjects: subject: Civics
subject: Moral education
subject: Italian
subject: società di docenti
subject: maestri
subject: maestre
subject: scuole infantili
subject: elementari minori
subject: elementari maggiori
subject: disegno
subject: ginnasio
subject: liceo
subject: direttori
subject: soci fondatori
subject: soci onorari
subject: obblighi
subject: diritti
subject: soccorsi
subject: amministrazione sociale

description: Documento conservato presso la Forschungsbibliothek Pestalozzianum, Pädagogische Hochschule Zürich.
Evaluation of DNA, BSA binding, and antimicrobial activity of new synthesized neodymium complex containing 29-dimethyl 110-phenanthroline
Creators: name: Moradi, Zohreh
name: Mozhgan Khorasani-Motlagh
name: Rezvani, Ali Reza
name: Meissam Noroozifar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: In order to evaluate biological potential of a novel synthesized complex [Nd(dmp)2Cl3.OH2] where dmp is 29-dimethyl 110-phenanthroline, the DNA-binding, cleavage, BSA binding, and antimicrobial activity properties of the complex are investigated by multispectroscopic techniques study in physiological buffer (pH 7.2).The intrinsic binding constant (Kb) for interaction of Nd(III) complex and FS–DNA is calculated by UV–Vis (Kb = 2.7 ± 0.07 × 105) and fluorescence spectroscopy (Kb = 1.13 ± 0.03 × 105). The Stern–Volmer constant (KSV), thermodynamic parameters including free energy change (ΔG°), enthalpy change (∆H°), and entropy change (∆S°), are calculated by fluorescent data and Vant’ Hoff equation. The experimental results show that the complex can bind to FS–DNA and the major binding mode is groove binding. Meanwhile, the interaction of Nd(III) complex with protein, bovine serum albumin (BSA), has also been studied by using absorption and emission spectroscopic tools. The experimental results show that the complex exhibits good binding propensity to BSA. The positive ΔH° and ∆S° values indicate that the hydrophobic interaction is main force in the binding of the Nd(III) complex to BSA, and the complex can quench the intrinsic fluorescence of BSA remarkably through a static quenching process. Also, DNA cleavage was investigated by agarose gel electrophoresis that according to the results cleavage of DNA increased with increasing of concentration of the complex. Antimicrobial screening test gives good results in the presence of Nd(III) complex system.
Additional file 2: Table S2. of Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?
Creators: name: Hall, Michelle
name: Hinman, Rana
name: van der Esch, Martin
name: van der Leeden, Marike
name: Kasza, Jessica
name: Wrigley, Tim
name: Metcalf, Ben
name: Dobson, Fiona
name: Bennell, Kim
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Linear relationships between change in strength-related measures (independent variable) and change on WOMAC function (dependent variable) according to physical dysfunction severity at baseline (complete cases n =80). (DOCX 21 kb)
title: A world of thousand independent regions. Transforming  the World to Small Countries as ‘Independent Regions’
Creators: name: Neis, Hans Joachim (Hajo)
name: Chaiwat, Pamanee
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: Countries, Independent Regions, Urban-Regional Development and Revitalization.

description: This paper proposes a fundamental socio-spatial alternative for reorganizing our world structure, countries and regions which can help and support the ever-increasing number of refugees and, at the same time, can try to reduce or even eradicate the human-made refugee problem altogether. When the idea of ‘Independent Regions’is put into the context of refugees, it presents itself as a necessary alternative to the current imbalance of few large and dominant countries in contrast to a large number of smaller countries. First, we look at the best that current countries or groups of countries can provide for refugees based on the Geneva Refugee Convention from 1951. Second, we explore an alternative, that is based on fundamental principles of ‘Independent Regions’ with an ideal population size for governing itself, that has the potential to reduce the root problem of refugee creation of big countries vs small counties. Third, we investigate how to transition existing structures of countries to form ‘A World of Independent Regions’ in Europe, United States, Middle East and Northern Africa. We conclude that a world of ‘Independent Regions’ provides a stronger potential to deal with current issues and problems facing the world than the current system.
Additional file 3: Table S3. of Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?
Creators: name: Hall, Michelle
name: Hinman, Rana
name: van der Esch, Martin
name: van der Leeden, Marike
name: Kasza, Jessica
name: Wrigley, Tim
name: Metcalf, Ben
name: Dobson, Fiona
name: Bennell, Kim
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Linear relationships between 12-week change in strength-related measures (independent variable) and 12-week change on WOMAC physical function (dependent variable) according to tertiles of physical dysfunction severity at baseline. (DOCX 26 kb)
Data Justice in Practice: A Guide for Impacted Communities
Creators: name: Leslie, David
name: Katell, Michael
name: Aitken, Mhairi
name: Singh, Jatinder
name: Briggs, Morgan
name: Powell, Rosamund
name: Rincón, Cami
name: Perini, Antonella
name: Jayadeva, Smera
Publisher: name: Zenodo
Year: 2022
Subjects: data justice
digital rights
data ethics
AI ethics
social justice
power
access
equity
participation
knowledge
data power
digital infrastructure
human rights
data colonialism
decolonial AI
economic justice
data feminism
design justice
pluriverse
post-development theory
intercultural ethics
intercultural communication

description: The Advancing Data Justice Research and Practice project aims to broaden understanding of the social, historical, cultural, political, and economic forces that contribute to discrimination and inequity in contemporary ecologies of data collection, governance, and use. This is the consultation draft of a guide for impacted communities. It provides actionable information for communities who wish to implement the principles and priorities of data justice. In the first section, we introduce the nascent field of data justice, from its early discussions to more recent proposals to relocate understandings of what data justice means. This section includes an account of the outreach we conducted with stakeholders throughout the world in developing a nuanced and pluralistic conception of data justice and concludes with a description of the six pillars of data justice around which this guidance revolves. Depending on their contexts, potential impacts, and scale, data activities may be carried out in a way that involves stakeholder engagement. To facilitate this process, the next section provides an explainer of the Stakeholder Engagement Process and the steps it includes—preliminary horizon scanning, policy scoping and stakeholder analysis, positionality reflection, and establishing stakeholder engagement objectives and methods. This section sets out considerations relating to internal community engagement (i.e. engagement within your community) as well as approaches to engaging external stakeholders (i.e. to inform or influence external activities). Additionally, it sets out considerations to be addressed when participating in externally-led engagement processes (e.g. where communities are invited to participate in stakeholder engagement initiated by developers or policy-makers). Finally, the last section presents the guiding questions that will help communities to address issues of data, digital infrastructures, and affected areas of civic, public, and private life, in relation to past, present and future dimensions of community life and in accordance with the six pillars of data justice.
description: This report was commissioned by the International Centre of Expertise in Montréal in collaboration with GPAI's Data Governance Working Group, and produced by the Alan Turing Institute. The research was supported, in part, by a grant from ESRC (ES/T007354/1), Towards Turing 2.0 under the EPSRC Grant EP/W037211/1, and from the public funds that make the Turing's Public Policy Programme possible.
Jung, arm und krank? Unterstützung für junge, psychisch belastete Sozialhilfebeziehende
Creators: name: Schwarz, Nathalie
Publisher: name: Zenodo
Year: 2020

description: Junge Erwachsene befinden sich in einer Phase des Übergangs. Es wird von ihnen erwartet, dass sie sich durch eine Ausbildung auf ihre berufliche Integration vorbereiten. Den meisten gelingt dieser Übergang. Allerdings haben immer mehr junge Erwachsene Mühe mit den zu bewältigenden Aufgaben und benötigen Unterstützung. Oftmals ist diese Gruppe betroffen durch Mehrfachproblematiken. Ausserdem stammen viele junge Erwachsene aus armutsbetroffenen Familien. Durch die mangelnden Ressourcen bleiben die Betroffenen auch nach der Ablösung aus dem Elternhaus in ihren prekären Lebenslagen. Zudem bleibt ihnen oftmals nur der Gang zum Sozialdienst übrig, um ihre Existenz zu sichern. Armutsbetroffene Menschen sind häufig infolge von psychosozialen Belastungsfolgen psychisch belastet. Junge Erwachsene sind daher nicht nur mit der Bewältigung von altersspezifischen Entwicklungsaufgaben beschäftigt, sie sind oftmals auch durch ihre Lebenslage psychisch belastet, diese Faktoren erschweren einen gelingenden Übergang. Die vorliegende Bachelorarbeit setzt sich zum Ziel anhand des ressourcenorientierten Ansatzes Sozialarbeitenden auf den Sozialdiensten eine Hilfestellung zu geben, um junge, psychisch belastete Menschen im Alter zwischen 18 und 25 Jahren zu unterstützen. Zunächst wird die Armut in der Schweiz beleuchtet sowie die Zusammenhänge zwischen Armut und psychischer Gesundheit aufgezeigt. Danach wird auf die Entwicklungsaufgaben junger Erwachsener eingegangen und die Schwierigkeiten aufgezeigt, wenn sie durch ihre Lebenslage psychisch belastet sind. Nach einer kurzen Einführung in die Sozialhilfe, werden anhand des ressourcenorientierten Ansatzes Praxisempfehlungen sowie Grenzen des ressourcenorientierten Ansatzes im Kontext der Sozialhilfe aufgezeigt.
description: + Code Diss LU: hslusa basa 2020 + Fussnote: Bachelorarbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit 2020 + NL-Code: NLLUHSA202002
METHODOLOGY OF FORMING THE TARGET BASIS OF ACTIONS IN TEACHING MATHEMATICAL ANALYSIS
Creators: name: Koshnazarov, Rasul
name: Rizaev, Rustam
name: Ibragimova, Dilnoza
Publisher: name: Zenodo
Year: 2024

description: in this article, the method of forming the target basis of actions in teaching mathematical analysis is analyzed, it is considered that students should acquire knowledge about the subject of mathematics, but also about the actions of a methodical nature, and the skills of ordering these actions, etc. It also includes knowledge that assesses the purposeful basis of actions, that is, knowing why the action is being performed.
Chondrotinase ABC I thermal stability is enhanced by site-directed mutagenesis: a molecular dynamic simulations approach
Creators: name: Kowsar Bagherzadeh
name: Monireh Maleki
name: Abolfazl Golestani
name: Khosro Khajeh
name: Amanlou, Massoud
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Hematology
subject: Computational Biology

description: Chondroitin sulfate proteoglycans (CSPGs) are potent inhibitors of growth in the adult central nervous system. Use of the enzyme chondroitinase ABC I (ChABC I) as a strategy to reduce CSPG inhibition in experimental models of spinal cord injury has led to observations of its remarkable capacity for repair. More importantly, ChABC therapy has been demonstrated to promote significant recovery of function to spinal injured animals. Despite this incomparable function of ChABC I, its clinical application has been limited because of its thermal instability as reported in the literature. In a recent study by Nazari-Robati et al., thermal stability of ChABC I was improved by protein engineering using site-directed mutagenesis method. Here, in this study, molecular dynamics simulations were used to take a closer look into the phenomenon leading to the experimentally observed thermal stability improvement followed by the corresponding site-directed mutagenesis. We concluded that the mutations induce local flexibility along with a re-conformation into the native structure which consequently increase the protein thermal stability.
Additional file 6: Table S3. of Transcriptomic analysis of Pak Choi under acute ozone exposure revealed regulatory mechanism against ozone stress
Creators: name: Zhang, Lu
name: Xu, Bin
name: Wu, Tao
name: Wen, Mu-xuan
name: Fan, Lian-xue
name: Feng, Zhao-zhong
name: Paoletti, Elena
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: The primers used for qRT -PCR. (DOC 33Â kb)
Scrutiny of the mechanism of small molecule inhibitor preventing conformational transition of amyloid-β42 monomer: insights from molecular dynamics simulations
Creators: name: Suniba Shuaib
name: Bhupesh Goyal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by loss of intellectual functioning of brain and memory loss. According to amyloid cascade hypothesis, aggregation of amyloid-β42 (Aβ42) peptide can generate toxic oligomers and their accumulation in the brain is responsible for the onset of AD. In spite of carrying out a large number of experimental studies on inhibition of Aβ42 aggregation by small molecules, the detailed inhibitory mechanism remains elusive. In the present study, comparable molecular dynamics (MD) simulations were performed to elucidate the inhibitory mechanism of a sulfonamide inhibitor C1 (2,5-dichloro-N-(4-piperidinophenyl)-3-thiophenesulfonamide), reported for its in vitro and in vivo anti-aggregation activity against Aβ42. MD simulations reveal that C1 stabilizes native α-helix conformation of Aβ42 by interacting with key residues in the central helix region (13–26) with hydrogen bonds and π–π interactions. C1 lowers the solvent-accessible surface area of the central hydrophobic core (CHC), KLVFF (16–20), that confirms burial of hydrophobic residues leading to the dominance of helical conformation in the CHC region. The binding free energy analysis with MM–PBSA demonstrates that Ala2, Phe4, Tyr10, Gln15, Lys16, Leu17, Val18, Phe19, Phe20, Glu22, and Met35 contribute maximum to binding free energy (−43.1 kcal/mol) between C1 and Aβ42 monomer. Overall, MD simulations reveal that C1 inhibits Aβ42 aggregation by stabilizing native helical conformation and inhibiting the formation of aggregation-prone β-sheet conformation. The present results will shed light on the underlying inhibitory mechanism of small molecules that show potential in vitro anti-aggregation activity against Aβ42.
title: Mail à Moncef Guenounou, Jean-Michel Molina, Jean-François Delfraissy, Pierre-louis Fagniez, Marie-Daniele Campion, retransféré à Arnold Munnich, Michel Kazatchkine, Patrice Debré - Pièce jointe
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Pièce jointe : "progrès dans l anti VIH 20 03 09.doc".
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111135799637
description: created: start=2009-06-05;end=2009-06-16
title: OFROM: interview avec ilcf21a31
Creators: name: Delafontaine, François
name: Zayed, Ahmad
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.626652i8.v2#9287889dd91db1fd9182a623c324db66d4252640
Additional file 10: Figure S5. of Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell
Creators: name: Wang, Hua
name: Zhang, Kunshan
name: Liu, Yifei
name: Fu, Yudong
name: Gao, Shan
name: Gong, Peng
name: Wang, Haiying
name: Zhou, Zhongcheng
name: Zeng, Ming
name: Wu, Zhenfeng
name: Sun, Yu
name: Chen, Tong
name: Li, Siguang
name: Liu, Lin
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: The mapping ratio of single cell libraries is not correlated with telomere length (T/R ratio). (a) Cumulative gene diversity plot showing the proportion of the library size accounted for by the expressed features across different telomere groups. (b) Linear regression analysis of telomere length (T/R ratio) and mapping ratio at single cell level. (PDF 223 kb)
XİZMAT TARTİBİDA YARATİLGAN MUALLİFLİK HUQUQİ ASARLARİ – XORİJİY TAJRİBA
Creators: name: Qahhorova, Sohiba
Publisher: name: Zenodo
Year: 2025

description: Xizmat tartibida yaratilgan mualliflik huquqi obyektlari — ish beruvchining ko‘rsatmasi yoki buyurtmasi asosida yaratilgan asarlardir. Bu asarlar, odatda, xodim tomonidan amalga oshiriladi, lekin ularning mualliflik huquqi ish beruvchiga tegishli bo‘lishi mumkin. Xizmat tartibida yaratilgan asarlarning huquqiy rejimi, asarlarning ijodiy faoliyat jarayonida kimning asosiy rol o‘ynaganiga, shuningdek, ish beruvchi va xodim o‘rtasidagi kelishuvlarga bog‘liq hisoblanadi. Odatda, mehnat shartnomasiga ko‘ra, xizmat tartibida yaratilgan asarlarning huquqlari ish beruvchiga o‘tadi. Bu holat ish beruvchining xodimga ishlash shartlarini belgilashda va ishlagan asarlardan foydalanishda to‘liq huquq berishiga imkon yaratadi, biroq, bunday tartibda yaratilgan asarlarda xodimning mualliflik huquqlari — shaxsiy nomulkiy huquqlari saqlanib qoladi. Shaxsiy nomulkiy huquqlar muallifning asarini asliyatda saqlash, uning nomidan foydalanish va asarning o‘ziga xosligini himoya qilish huquqlarini o‘z ichiga oladi.
Primo anno.. quante cose da mettere in valigia! I fatti significativi del primo anno lavorativo del neodocente per la costruzione della propria identità professionale
Creators: name: Regazzi, Lisa
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2013

description: È una ricerca qualitativa, condotta tramite interviste semi-strutturate, che mira a far luce su alcuni interrogativi che si riferiscono a cosa accade nel primo anno scolastico in Ticino per un neodocente di scuola elementare, con un posto di lavoro fisso al 50 % oppure al 100%. Questa ricerca vuole mostrare i vissuti significativi in gioco nel primo anno lavorativo, che permettono al neodocente di essere riconosciuto nel proprio ruolo di insegnante, contribuendo così alla costruzione della propria identità professionale. L’analisi dei dati ha permesso di capire quali vissuti vengono reputati come significativi dai neodocenti, quali tra essi sono indicati come fatti problematici o di grande soddisfazione e quali dimensioni sono in gioco. Dai risultati ottenuti si evince che anche il vissuto più semplice può assumere un grande valore formativo e che la dimensione occupazionale condiziona alcune delle altre dimensioni e la costruzione stessa dell’identità professionale del neodocente. La componente relazionale si è rivelata trasversale a tutte le dimensioni, come la personalità del neodocente. Grazie soprattutto alle competenze riflessive, i fatti apparsi inizialmente problematici, si sono poi rivelati formativi. Quindi la personalità del neodocente e le occasioni di lavoro e di interazione con gli altri si rivelano i fattori principali della costruzione dell’identità professionale, la quale è dunque un continuo lavoro di socializzazione e di lavoro con se stessi e su stessi. Relatore: Silvio Canevascini
title: OFROM: interview avec ilcf21a30
Creators: name: Delafontaine, François
name: Chnebly, Igor
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.7d2ax1r2.v2#c0c6fb7a8cecd823b81120787f1db9f1824c21e0
Spectroscopic investigation on interaction of biogenic, Croton bonplandianum leaves extract mediated potential bactericidal silver nanoparticles with human hemoglobin and human serum albumin
Creators: name: Maidul Beg
name: Anukul Maji
name: Mandal, Amit Kumar
name: Das, Somnath
name: Jha, Pradeep K.
name: Maidul Hossain
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: The green synthesis of nanoparticles has received increasing attention due to the growing demand to produce safe, cost-effective, and eco-friendly technology for nanomaterials synthesis. We report on the use of aqueous Croton bonplandianum (Family: Euphorbiaceae, Genus: Croton) leaves extract for the preparation of silver nanoparticles (AgNPs) without using any external reducing and stabilizing agent. Ultraviolet–visible spectroscopy showed maximum absorbance at 446 nm due to surface plasmon resonance of AgNPs. Energy dispersive X-ray spectra also supported the existence of AgNPs. An average diameter (d = ~17.4 nm) of the spherical AgNPs was determined from the transmission electron microscopic images. Hydrodynamic size (d = ~21.1 nm) was determined by dynamic light scattering. Fourier transform infrared analysis designed that the functional groups like O–H, N–H, , CONH2, and COOH participated in the AgNPs formation. The negative zeta potential value (−19.3 mV) of the AgNPs indicated its dispersion and stability. The AgNPs exhibited strong antibacterial activity against Escherichia coli ATCC 25922 and 1.5 nM proved to be minimum inhibitory concentration for it. Hemolysis assay demonstrated the blood compatibility of the AgNPs toward human RBCs. The binding affinity of the AgNPs toward human hemoglobin and human serum albumin (HSA) was also determined by means of fluorescence spectroscopy. The circular dichroism spectroscopy revealed that the native structures of human hemoglobin and HSA remain unchanged, but its secondary structures were slightly changed upon interaction with AgNPs. Overall, it can be concluded that the AgNPs may be applied in the area of nanomedicines.
Methods and Materials (CREP #23-09)
Creators: name: Salvayre, Hugo
name: Maxyme Gallo
name: Jahier Léna
name: Gourdon-Kanhukamwe, Amélie
name: Bernard, Chloé
Publisher: name: OSF Registries
Year: 2020
Subjects: CREP

description: Here, you will find all our method and our annexes in french and english.
Additional file 1: Table S1. of Comparative analyses of plastid genomes from fourteen Cornales species: inferences for phylogenetic relationships and genome evolution
Creators: name: Fu, Chao-Nan
name: Li, Hong-Tao
name: Milne, Richard
name: Zhang, Ting
name: Ma, Peng-Fei
name: Yang, Jing
name: Li, De-Zhu
name: Gao, Lian-Ming
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The primers newly designed in this study for four junctions and two genes (rpl22, ycf15). Table S2. Molecular models selected for all the data sets of the three alignment strategies. Table S3. Model selected for each data partition identified by software PartitionFinder for unfiltered complete plastid genomes. Table S4. Gene category and gene contained in plastid genomes of Cornales. (DOC 147Â kb)
Riscopriamo la scrittura a mano
Creators: name: Mazzolini, Mara
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2014

description: In Italia la scrittura a mano sta andando via via perdendosi; le principali cause di questo fenomeno sono rintracciabili da un lato nello sviluppo della tecnologia, che implica un uso quasi esclusivo dei mezzi informatici per la comunicazione scritta, dall’altro nei cambiamenti apportati ai programmi d’insegnamento nelle scuole. Al giorno d’oggi, in Italia, non viene più dato molto rilievo alla scrittura a mano, tanto che spesso viene insegnata in modo inadeguato o superficiale, ma non sempre fu così; fino agli anni sessanta, e specialmente prima della Riforma Gentile (1923), la scrittura a mano costituiva una materia a sé, Calligrafia, insegnata e valutata a tutti i livelli d’istruzione, dalle elementari alle superiori, ma successivamente ha subito un drastico ridimensionamento, finendo con l’essere esclusa del tutto dai curriculum scolastici. Un tempo saper scrivere bene poteva essere un vanto, tanto che per invidia, tra quelli che avevano una pessima scrittura, vigeva la credenza che la bella grafia fosse “l’arte degli sciocchi” 1. Indubbiamente avere una bella scrittura non significa necessariamente essere intelligenti, ma veniva molto apprezzata e la si riteneva importante anche solo per un fattore estetico o per orgoglio personale.
title: OFROM: interview avec ilcf21a29
Creators: name: Delafontaine, François
name: Chlebny, Igor
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.babe7fav.v2#90105f441a44101715aeab99d7552aa013c27ad0
Structure formation in sugar containing pectin gels - Influence of gel composition and cooling rate on the gelation of non-amidated and amidated low-methoxylated pectin
Creators: name: Kastner, Hanna
name: Einhorn-Stoll, Ulrike
name: Drusch, Stephan
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 664 Lebensmitteltechnologie
subject: pectin
subject: gelling process
subject: rheology
subject: cooling rate
subject: calcium
subject: pH

description: Gel structure formation and gel properties of low-methoxyl pectin (LMP) and low-methoxyl amidated pectin (LMAP) with similar degree of methoxylation have been investigated by oscillatory rheological measurements. The gelling process was examined in a sugar-acid environment matching the conditions in jams and jellies. Factors studied included cooling rate, calcium content and pH. Parameters derived from the rheological measurements comprised the gel point, structuring velocity, initial and critical structuring temperature, average structuring developing rate and loss factor (tanδend). The influence of the cooling rate on the gelling process of LMP was moderate and the influence on the final gel properties was significant, tanδend decreased with increasing cooling rate. The calcium content significantly affected the structuring process of LMAP and the final gel properties. At high calcium content, the gelling process started at a higher temperature but the resulting gels were less strong. The pH had a significant but partly opposite effect on the gelation of LMP as well as LMAP. The differences in gelation behavior between LMP and LMAP can be explained by the lower number of available blocks of free carboxyl groups in LMAP as well as by the formation of additional hydrogen bonds through the amide groups.
Exclusive breastfeeding until 6 months postpartum in Lebanon - a systematic review and an online survey
Creators: name: Zablith, Nadine
Publisher: name: Lancaster University
Year: 2020

description: Breastfeeding is the ultimate food source for infants and it is highly valuable for both mothers and children’s health. The WHO recommends exclusive breastfeeding (EBF) until six months postpartum. In Lebanon, the EBF rates until six months postpartum are amongst the lowest worldwide, and the factors affecting EBF have been rarely investigated. A systematic review to determine the associations between socio-cultural-demographic factors and EBF at six months postpartum in middle-income countries was conducted. The review has shown that the most frequently reported determinant of EBF was maternal employment, followed by maternal education and maternal age. This study was the first in Lebanon to explore the association between certain demographic, social and cultural factors with EBF for the six months postpartum of mothers residing across Lebanon. The study employed social media to recruit 593 mothers to complete an online questionnaire. Data analysis consisted of bivariate analysis and multivariate logistic regressions. The findings show that EBF until six months postpartum is not associated with the housekeeper presence, positively associated with having a prenatal plan to breastfeed, the mother disagreeing that free formula samples should be distributed to the mothers after delivery at the hospital, having the baby’s crib kept by the mother’s bed side at the hospital, not being offered a free formula sample at the hospital, the mother’s partner perceiving breastfeeding as very important, not having the mother’s father living in the same household besides the partner and children when the child was between zero and six months and being non-Lebanese. It is the first study conducted in low and middle-income countries to explore the maternal attitudes and opinions regarding feeding practices and their association with EBF until six months. This study shows that ensuring appropriate systems, services and support for mothers, while applying the social-ecological model, should be a priority for the stakeholders to improve maternal and child health.
The simultaneous determination of capsaicinoids, tocopherols, and carotenoids in pungent pepper powder
Creators: name: Nagy, Zsuzsa
name: Daood, Hussein
name: Koncsek, Arnold
name: Molnár, Helga
name: Helyes, Lajos
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: From nutritional points of view, carotenoids, capsaicinoids, and tocopherols are valuable constituents in pungent peppers. A rapid and reliable high performance liquid chromatography (HPLC) method for the simultaneous determination of phytonutrients in spice red peppers and chili products was developed and validated. The method included simultaneous detection by fluorescence and diode-array detectors. The major capsaicinoids, two tocopherols and 43 carotenoid components, were simultaneously separated, detected, and identified in the appointed pepper powder (containing Capsicum annuum and Capsicum frutescens) for method validation. The separation was performed on a Nucleosil C18 reverse phase column and optimized gradient elution. Resolution ranged between 0.96 and 1.46 with the highest values corresponding to γ-tocopherol and α-tocopherol. The limits of detection and quantification of target compounds ranged between 18.77 and 148.08 ng mL−1. Recoveries were between 89.83–100.26 and 79.72–88.86% when standard materials were spiked at low and high amounts, respectively. The most sufficient extraction of the different phytonutrients was achieved by mixture of methanol and acetone, although it was only slightly better than the mixture of methanol and acetonitrile. These results suggest that the developed method could be used for rapid, one-step determination of a wide range of phytonutrients in chili and pepper powders.
Large-scale meta-analytic approaches for systematic and reproducible associations between the human microbiome and host's conditions: supplementary materials
Creators: name: Paolo, Manghi
Publisher: name: Zenodo
Year: 2022

description: This project contains the supplementary files of the PhD thesis "Large-scale meta-analytic approaches for systematic and reproducible associations between the human microbiome and host's conditions". This thesis consists of 4 main papers, two of which are in submission. A copy of their supplementary materials is therefore available here.
Large-scale meta-analytic approaches for systematic and reproducible associations between the human microbiome and host's conditions: supplementary materials
Creators: name: Manghi Paolo
Publisher: name: Zenodo
Year: 2022

description: This project contains the supplementary files of the PhD thesis "Large-scale meta-analytic approaches for systematic and reproducible associations between the human microbiome and host's conditions". This thesis consists of 4 main papers, two of which are in submission. A copy of their supplementary materials is therefore available here.
Additional file 2: Fig. S1. of Comparative analyses of plastid genomes from fourteen Cornales species: inferences for phylogenetic relationships and genome evolution
Creators: name: Fu, Chao-Nan
name: Li, Hong-Tao
name: Milne, Richard
name: Zhang, Ting
name: Ma, Peng-Fei
name: Yang, Jing
name: Li, De-Zhu
name: Gao, Lian-Ming
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: A percent identity plot showing the overall sequence similarity of the fourteen Cornales plastid genomes. Fig. S2. Phylogenetic relationships of Cornales based on three different data sets with light filtered alignment. Fig. S3. Phylogenetic relationships of Cornales based on three different data sets with strict filtered alignment. (PDF 1121Â kb)
Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase
Creators: name: Tanaka, Miyuki
name: Takahara, Michiyo
name: Nukina, Kohei
name: Hayashi, Akiyo
name: Sakai, Wataru
name: Sugasawa, Kaoru
name: Shiomi, Yasushi
name: Nishitani, Hideo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Cdt1 is rapidly degraded by CRL4Cdt2 E3 ubiquitin ligase after UV (UV) irradiation. Previous reports revealed that the nucleotide excision repair (NER) pathway is responsible for the rapid Cdt1-proteolysis. Here, we show that mismatch repair (MMR) proteins are also involved in the degradation of Cdt1 after UV irradiation in the G1 phase. First, compared with the rapid (within ∼15 min) degradation of Cdt1 in normal fibroblasts, Cdt1 remained stable for ∼30 min in NER-deficient XP-A cells, but was degraded within ∼60 min. The delayed degradation was also dependent on PCNA and CRL4Cdt2. The MMR proteins Msh2 and Msh6 were recruited to the UV-damaged sites of XP-A cells in the G1 phase. Depletion of these factors with small interfering RNAs prevented Cdt1 degradation in XP-A cells. Similar to the findings in XP-A cells, depletion of XPA delayed Cdt1 degradation in normal fibroblasts and U2OS cells, and co-depletion of Msh6 further prevented Cdt1 degradation. Furthermore, depletion of Msh6 alone delayed Cdt1 degradation in both cell types. When Cdt1 degradation was attenuated by high Cdt1 expression, repair synthesis at the damaged sites was inhibited. Our findings demonstrate that UV irradiation induces multiple repair pathways that activate CRL4Cdt2 to degrade its target proteins in the G1 phase of the cell cycle, leading to efficient repair of DNA damage.
The Simultaneous Determination of Capsaicinoids, Tocopherols and Carotenoids in Pungent Pepper Powder
Creators: name: Nagy, Zsuzsa
name: Daood, Hussein
name: Koncsek, Arnold
name: Molnár, Helga
name: Helyes, Lajos
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: From nutritional points of view carotenoids, capsaicinoids and tocopherols are valuable constituents in pungent peppers. A rapid and reliable HPLC method for the simultaneous determination of phytonutrients in spice red peppers and chili products was developed and validated. The method included simultaneous detection by fluorescence and diode-array detectors. The major capsaicinoids, two tocopherols and 43 carotenoid components were simultaneously separated, detected and identified in the appointed pepper powder (containing Capsicum annuum and Capsicum frutescens) for method validation. The separation was performed on a Nucleosil C18 reverse phase column and optimized gradient elution. Resolution ranged between 0.96 and 1.46 with the highest values corresponding to γ-tocopherol and α -tocopherol. The limits of detection (LOD) and quantification (LOQ) of target compounds ranged between 18.77 and 148.08 n g mL−1. Recoveries were among 89.83–100.26% and 79.72–88.86% when standard materials were spiked at low and high amounts respectively. The most sufficient extraction of the different phytonutrients was achieved by mixture of methanol and acetone, although it was only slightly better than the mixture of methanol and acetonitrile. These results suggest that the developed method could be used for rapid, one-step determination of a wide range of phytonutrients in chili and pepper powders.
Additional file 12: Figure S6. of Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell
Creators: name: Wang, Hua
name: Zhang, Kunshan
name: Liu, Yifei
name: Fu, Yudong
name: Gao, Shan
name: Gong, Peng
name: Wang, Haiying
name: Zhou, Zhongcheng
name: Zeng, Ming
name: Wu, Zhenfeng
name: Sun, Yu
name: Chen, Tong
name: Li, Siguang
name: Liu, Lin
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Functional annotation analysis of the differentially expressed genes from long, medium and short telomere groups. Functional annotation was performed by the assignment of Gene Ontology (GO) terms, and differentially expressed genes were annotated based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) using the R package SCDE. (PDF 1040 kb)
Mixed Reality alla Swissminiatur
Creators: name: Ferrari, Alessandro
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2019

description: Swissminiatur é un parco in miniatura all’aperto a Melide che espone oltre 120 modelli in miniatura di alcuni tra gli edifici e monumenti più famosi o importanti della Svizzera. Attratta dalle nuove tecnologie, Swissminiatur vuole capire quali sono le opportunità offerte dalla mixed reality e in quale modo questa tecnologia può essere integrata all'interno del parco. OWL Solutions é un’azienda ticinese che fornisce servizi di consulting per piccole e medie imprese con lo scopo di agevolare la transizione all’era digitale. Le due aziende hanno contattato SUPSI con lo scopo di eseguire uno studio di fattibilità in grado di fornire alcune risposte a Swissminiatur. Lo studio consiste nello sviluppo di un’applicazione per smartphone in mixed reality in grado di aumentare il modello di Piazza Grande a Locarno durante il Festival del Film di Locarno. L’applicazione é stata sviluppata per dispositivi Android e iOS utilizzando la piattaforma di sviluppo Unity3D e il kit di sviluppo per realtà aumentata Vuforia. L’applicativo risultate é stato accolto positivamente del committente e soddisfa tutti i requisiti delineati nel mandato. Tuttavia, allo scopo di migliorare la qualità del prodotto in possibili future iterazioni, ulteriore ricerca é necessaria nelle tecnologie per la realtà aumentata per uso all’esterno. Mobile Augmented Reality is a powerful and versatile tool that allows real world scenarios and environments captured through a device's camera to be enriched with virtual content. Such technology has been adopted to popular acclaim in games like Pokémon Go or utilty applications like Google Lens, as well as in a variety of travel and tourism-related applications. We were approached by Swissminiatur, a miniature park, to develop a proof of concept application to explore the viability and possible limitations of modern AR technology. The focus is on their scale replica of Piazza Grande in Locarno during the Locarno Film Festival and the application is to augment the model by adding the projection of a virtual video on the big screen, a crowd of people roaming the square, as well as the ability for users to browse further information on the model. The application was developed as multi-platform Android and iOS application based on the Unity game engine, using the Vuforia SDK as the provider of AR functionality. The final product meets all requirements set and was met positively by the client. However, while functional, it brings to light the shortcomings of using image-based tracking methods and marker-based solutions in outdoor and large scale environments. Ultimately, further research and development is needed to ensure a robust and reliable tracking method is implemented, and a few alternatives are proposed in the Future Developments chapter of this document.