cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dataset belonging to article: Cell stiffening is a label-free indicator of superoxide-induced intracellular acidification
Creators: name: Yesaswini Komaragiri 1, 2
name: Ricardo Hugo Pires 1, 2
name: Stefanie Spiegle 1, 2
name: Huy Tung Dau
name: Doreen Biedenweg1, 3
name: Clara Ortegón Salas4
name: Md. Faruq Hossain1
name: Bob Fregin1, 2
name: Stefan Gross2, 3
name: Manuela Gellert4
name: Uwe Lendeckel4
name: Christopher Horst Lillig4
name: Oliver Otto1, 2*
Publisher: name: Zenodo
Year: 2024

description: The files contains the raw data files of the data presented in the following manuscript, "Cell stiffening is a label-free indicator of superoxide-induced intracellular acidification". The files are arranged according to the figures.

Fig.1b and c.zip- This folder contain .rtdc file format. The data can be read by shapeOut and ShapeOut2 softwares which can be downloaded from https://www.zellmechanik.com/Download.html. 

Fig.2- WB and 2D-rawdata.zip- This folder contains the blot images of 1D western blots which can be analysed by using imagej or fiji. The file also contain the 2D diagonal blot images in .svg format, .scn files of the blots which can be opened using image studio.

Fig.S10.data Intensity and position-rawdata and rscripts.zip- This folder contain the raw data and r-scripts used to analyse the intensity and position of F-actin and microtubule

Fig.3a and c-pH-raw-data.zip- This folder contain .fcs and data analysis of pH curve. 

Fig.3b-pH calibration curve-data.zip- This folder contain .rtdc files.

Fig.4a and b-Lysotracker and AO staining.zip- This folder contain the raw data in .czi and image files in .tif  format.

Fig.4c- viscosity -dRT-DC data.zip- This folder contain raw data for dRT-DC files in .csv, ,text, .tdms and .tsv file formats

Fig.5a-HL60 derived neutrophils- This folder contain .rtdc files.

Fig.5b-RTDC-Primary neutrophils.zip- This folder contain .rtdc files.

Fig.5b-RTDC-Jurkat.zip- This folder contain .rtdc files.

Fig.5- other cell models-pH analysis.zip-.text files.
Testing the heating method with perturbation theory
Creators: name: Alles, B.
name: Beccaria, M.
name: Farchioni, F.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The renormalization constants present in the lattice evaluation of the topological susceptibility can be non-perturbatively calculated by using the so-called heating method. We test this method for the $O(3)$ non-linear $σ$-model in two dimensions. We work in a regime where perturbative calculations are exact and useful to check the values obtained from the heating method. The result of the test is positive and it clarifies some features concerning the method. Our procedure also allows a rather accurate determination of the first perturbative coefficients.
description: 15 pages, LaTeX file, needs RevTeX style. Tarred, gzipped, uuencoded
Flame surface density modelling for the large eddy simulation of turbulent premixed flames
Creators: name: Ma, Terence Kwai Kin
Publisher: name: Imperial College London
Year: 2013

description: Large Eddy Simulation (LES) has become an increasingly useful tool for the prediction of turbulent reactive flows with the increasing availability of cheaper and faster computing power. In the context of premixed combustion, LES encounters the challenge of resolving the flame thickness, which is normally smaller than the filter width used in typical engineering applications. This thesis considers the Flame Surface Density (FSD) approach to provide closure to the filtered LES reaction rate. The FSD can either be modelled algebraically (FSDA) or determined through a transport equation (FSDT) and both approaches are investigated in the LES of three different test cases. The first case explores the response of different FSDA models towards changes in turbulence levels, and compares the instantaneous flame structures and reaction rates predicted by FSDA and FSDT methods. The remaining cases examine the LES of two turbulent premixed burners. A relatively large range of FSDA models are tested under the same operating conditions for the first time, and the LES-FSDT equation is applied to premixed flames that involve a higher level of geometric complexity than earlier work. Generally, the results show that the performance of some FSDA models are inconsistent between the two premixed burners, suggesting that the models may operate optimally under different turbulent conditions. By contrast, the consistently good agreement of the FSDT results with experiments suggests that the method has much potential in the LES modelling of turbulent premixed flames. However, the improved FSDT predictions were dependent on the value of the model constant within the sub-grid curvature model, and the value yielded an additional dependency on filter width. For these reasons as well as for the higher computational expense, the effective use of FSDT requires further development, while the application of the FSDA models remains a viable alternative to the FSDT approach.
Synthesis and catalytic activity of silver N-heterocyclic carbene complexes based on bis(3,5-dimethylpyrazol-1-yl)methyl-substituted pyridylimidazole
Creators: name: Hao, Hai-Jun
name: Chen, Dan-Feng
name: Zhang, Wei
name: Li, Xin
name: Wang, Ke-Feng
name: Lei, Jun-Yu
name: Tang, Liang-Fu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: A series of N-heterocyclic carbene (NHC) silver complexes derived from 6-[bis(3,5-dimethylpyrazol-1-yl)methyl]-2-pyridylimidazole have been synthesized and characterized by physico-chemical and spectroscopic methods, and the structures of four complexes have been confirmed by X-ray structural analyses. The functionalized NHC is a monodentate ligand in (NHC)AgCl through the carbene carbon atom, and a bridging [C,N,N] tridentate ligand in (NHC)2Ag2(BF4)2 and (NHC)2Ag2(PF6)2 through two pyrazolyl nitrogens and the carbene carbon to form a metallomacrocycle, in which a head (carbene)– to tail (nitrogen) coordination mode to two silver atoms is observed. Preliminary catalytic tests show that these newly synthesized Ag–NHC complexes exhibit excellent catalytic activity at a low catalyst loading (0.1–1 mol%) in the aldehyde–amine–alkyne coupling reaction.
Plenty of Room at the Top radio program, circa 1958-1959
Publisher: name: Columbia University
Year: 2020
Subjects: Motion picture producers and directors
Actors
Motion pictures

description: "Plenty of Room at the Top" is an episode of the "Memoirs of the Movies" series, produced by Group W of the Westinghouse Broadcasting Company in collaboration with Columbia University's Oral History Research Office
Additional file 1 of Lipid alterations play a role in the integration of PD-1/PD-L1 inhibitors and anlotinib for the treatment of advanced non–small-cell lung cancer
Creators: name: Liu, Li
name: Zhang, Shuo
name: Yang, Hai-Yan
name: Zhou, Chun-Hua
name: Xiong, Yi
name: Yang, Nong
name: Tian, Ye
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Molecular Biology
Pharmacology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 1: Supplemental Fig. 1. The potential mechanism by which abnormal elevations of PG and PI hinder the beneficial effects of combining anlotinib with PD-1/PD-L1 inhibitors for patients. During the analysis of Pearson correlation, a positive correlation between PG and PI was observed in each response group (PR, SD, and PD). This indicates that an increase in PG content corresponds to an increase in PI content, and vice versa. A hypothesis is proposed that the elevation of PG/PI levels could activate the PI3K-AKT pathway. This is because PI can act as a substrate for PIP2, which is phosphorylated by PI3K. Activation of the PI3K-AKT pathway has been linked to promoting tumor growth.
A luminous blue kilonova and an off-axis jet from a compact binary merger at z=0.1341
Creators: name: Troja, E.
name: Ryan, G.
name: Piro, L.
name: van Eerten, H.
name: Cenko, S. B.
name: Yoon, Y.
name: Lee, S. -K.
name: Im, M.
name: Sakamoto, T.
name: Gatkine, P.
name: Kutyrev, A.
name: Veilleux, S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The recent discovery of a faint gamma-ray burst (GRB) coincident with the gravitational wave (GW) event GW 170817 revealed the existence of a population of low-luminosity short duration gamma-ray transients produced by neutron star mergers in the nearby Universe. These events could be routinely detected by existing gamma-ray monitors, yet previous observations failed to identify them without the aid of GW triggers. Here we show that GRB150101B was an analogue of GRB170817A located at a cosmological distance. GRB 150101B was a faint short duration GRB characterized by a bright optical counterpart and a long-lived X-ray afterglow. These properties are unusual for standard short GRBs and are instead consistent with an explosion viewed off-axis: the optical light is produced by a luminous kilonova component, while the observed X-rays trace the GRB afterglow viewed at an angle of ~13 degrees. Our findings suggest that these properties could be common among future electromagnetic counterparts of GW sources.
description: 28 pages, 8 figures, 2 tables. Accepted for publication
The metal absorption systems of the Hubble Deep Field South QSO
Creators: name: Savaglio, Sandra
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Hubble Deep Field South (HDFS) has been recently selected and the observations are planned for October 1998. We present a high resolution (FWHM $\simeq 14$ \kms) spectrum of the quasar J2233--606 ($z_{em}\simeq2.22$) which is located 5.1 arcmin East of the HDFS. The spectrum obtained with the New Technology Telescope redward of the Lyman--$α$ emission line covers the spectral range 4386--8270 Å. This range corresponds to redshift intervals for CIV and MgII intervening systems of $z=1.83-2.25$ and $z=0.57-1.95$ respectively. The data reveal the presence of two complex intervening CIV systems at redshift $z=1.869$ and $z=1.943$ and two complex associated ($z_{abs} \approx z_{em}$) systems. Other two CIV systems at $z=1.7865$ and $z=2.077$, suggested by the presence of strong Lyman--$α$ lines in low resolution ground based and Hubble Space Telescope (HST) STIS observations (Sealey et al. 1998) have been identified. The system at $z=1.943$ is also responsible for the Lyman limit absorption seen in the HST/STIS spectrum. The main goal of the present work is to provide astronomers interested in the Hubble Deep Field South program with information related to absorbing structures at high redshift, which are distributed along the nearby QSO line of sight. For this purpose, the reduced spectrum, obtained from three hours of integration time, has been released to the astronomical community.
description: revisited version accepted for publication by Astronomical Journal; minor changes; typographical errors corrected; results and discussion unchanged
A Markov Chain Model for the Cure Rate of Non-Performing Loans
Creators: name: Boutchaktchiev, Vilislav
Publisher: name: arXiv
Year: 2018
Subjects: subject: Risk Management (q-fin.RM)
subject: Applications (stat.AP)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences
subject: 62M05, 62N02, 91B70

description: A Markov-chain model is developed for the purpose estimation of the cure rate of non-performing loans. The technique is performed collectively, on portfolios and it can be applicable in the process of calculation of credit impairment. It is efficient in terms of data manipulation costs which makes it accessible even to smaller financial institutions. In addition, several other applications to portfolio optimization are suggested.
Miracles de Nostre Dame
Creators: name: Gautier De Coinci
name: De Coinci, Gautier
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Langue et littérature françaises médiévales

description: Texte en français médiéval. Date de composition : ca. 1218-1227 (1218 - 1227), domaine : religieux, genre : miracle, forme : vers
description: Bibliographic citation: Gautier de Coinci, Miracles de Nostre Dame, édité par Victor Frederic Koenig, Genève, 1966. Publié en ligne par la Base de français médiéval, http://catalog.bfm-corpus.org/gcoin1. Dernière révision le 2012-11-18.
Synthesis, crystal structure and luminescence of [(CH3)3S]2ZrCl6
Creators: name: Tagiara, Nagia S.
name: Psycharis, Vassilis
name: Kaltzoglou, Andreas
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The current work reports on the synthesis, crystal structure and optoelectronic properties of (Me3S)2ZrCl6, prepared by reacting the solid precursors (Me3S)Cl and ZrCl4 in pyrex tubes at 150 °C under vacuum. According to X-ray powder diffraction and Rietveld analysis, (Me3S)2ZrCl6 crystallizes in the cubic space group Pa-3 (No. 205) with a = 12.4664(1) Å. The crystal structure consists of isolated trigonal pyramidal trimethylsulfonium cations and octahedral [ZrCl6]2- anions with weak hydrogen bonds among them and no signs of structural disorder. This 0D-material is stable in air and dissolves in water and dimethylformamide. Raman spectroscopy shows characteristic vibrational modes for the organic and inorganic moieties over the frequency range of 5–3200 cm−1. UV-Vis spectroscopy reveals a large band gap of 5.1 eV and a broadband luminescence with emission maximum at 465 nm in the solid state. The luminescent properties of (Me3S)2ZrCl6 are discussed and compared with those of similar inorganic or metal-organic compounds.
Radio broadcast of an interview with Malcolm X, 1962
Publisher: name: Columbia University
Year: 2020
Subjects: African American civil rights workers
Black Muslims
Police brutality--United States

description: Malcolm X discusses the events leading up to a violent assault on Nation of Islam Temple No. 27 by Los Angeles Police Department officers on the night of April 27, 1962, during which seven Muslims were shot and one man, Ronald Stokes, was killed. He describes how a dispute stemming from police harassment of Muslim men removing dry cleaning from a car quickly led to a retaliatory raid on the mosque by the LAPD. Malcolm X goes on to detail how unarmed members of the mosque were indiscriminately beaten and shot by police, arrested and held without medical treatment, and subjected to taunting and racial epithets from officers. He concludes by sharing his views on how Muslims should respond to police violence and his thoughts on seeking justice for the incident
Continuation of trastuzumab beyond progression in HER2-positive advanced esophagogastric cancer: a meta-analysis
Creators: name: Veer, Emil Ter
name: Ende, Tom Van Den
name: Creemers, Aafke
name: Waal, Laura De
name: Oijen, Martijn G.H. Van
name: Laarhoven, Hanneke W.M. Van
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Introduction: After progression on first-line trastuzumab-based therapy, no HER2-targeted agent is available for patients with HER2-positive esophagogastric cancer. However, continuation of trastuzumab after progression is an established strategy in HER2-positive breast cancer. We conducted a meta-analysis to investigate whether continuation of trastuzumab beyond first-line therapy in combination with chemotherapy is more effective compared to chemotherapy-alone. Methods: PubMed, EMBASE, CENTRAL and meeting abstracts from ASCO and ESMO were searched up to June 2018 for studies (any design) investigating second-line trastuzumab plus chemotherapy compared to chemotherapy-alone for patients with HER2-positive esophagogastric cancer that progressed on first-line trastuzumab-based therapy. Meta-analysis was performed on the primary outcome, overall survival (OS), and on secondary outcomes progression-free survival (PFS), objective-response rate (ORR), and adverse events. Results: Four cohort studies and one randomized controlled trial (RCT) were included with n = 200 patients who received second-line trastuzumab plus chemotherapy and n = 183 who received chemotherapy-alone. Meta-analysis showed that trastuzumab plus chemotherapy did not prolonged OS [HR = 0.72, 95% confidence interval (95% CI) = 0.47–1.08, p=.11). PFS was longer with trastzumab plus chemotherapy compared to chemotherapy-alone (HR = 0.64, 95% CI = 0.45–0.91, pp=.13) and no significant differences in grade 3/4 and grade 1/2 adverse events. Conclusions: This meta-analysis showed that patients who progressed on first-line trastuzumab-based therapy but of whom trastuzumab was continued in second-line and added to chemotherapy did not show longer OS or a higher ORR compared to patients receiving second-line chemotherapy-alone. However, PFS was prolonged and trastuzumab was not associated with additional safety concerns. In absence of available second-line HER2-targeted agents, a large prospective RCT should investigate if continuation of trastuzumab might be an attractive strategy, as this meta-analysis was mostly based on non-randomized studies and a RCT with a small sample size.
Detection and Removal of B-mode Dust Foregrounds with Signatures of Statistical Anisotropy
Creators: name: Philcox, Oliver H. E.
name: Sherwin, Blake D.
name: van Engelen, Alexander
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Searches for inflationary gravitational wave signals in the CMB B-mode polarisation are expected to reach unprecedented power over the next decade. A major difficulty in these ongoing searches is that galactic foregrounds such as dust can easily mimic inflationary signals. Though typically foregrounds are separated from primordial signals using the foregrounds' different frequency dependence, in this paper we investigate instead the extent to which the galactic dust B-modes' statistical anisotropy can be used to distinguish them from inflationary B-modes, building on the work of Kamionkowski and Kovetz (2014). In our work, we extend existing anisotropy estimators and apply them to simulations of polarised dust to forecast their performance for future experiments. Considering the application of this method as a null-test for dust contamination to CMB-S4, we find that we can detect residual dust levels corresponding to $r\sim0.001$ at $2σ$, which implies that statistical anisotropy estimators will be a powerful diagnostic for foreground residuals (though our results show some dependence on the dust simulation used). Finally, considering applications beyond a simple null test, we demonstrate how anisotropy statistics can be used to construct an estimate of the dust B-mode map, which could potentially be used to clean the B-mode sky.
description: 20 pages, 13 figures, accepted by MNRAS
How adaptation changes the climate game : climate change regimes in a non-cooperative, asymmetric world
Creators: name: Leib, Joerg
Publisher: name: Imperial College London
Year: 2012

description: The history of the UNFCCC climate negotiations over the past 20 years has shown how difficult it is to reach an international climate agreement that is both legally binding and environmentally effective enough to ensure that humankind can avoid the worst consequences projected from climate change. Some experts even see the world drifting towards a 4°C mean temperature rise. It is therefore necessary to start exploring what future, non-cooperative climate change regimes might be expected to look like. One immediate consequence is that adaptation to climate change has become increasingly relevant; on a humanitarian, political, economic and the scientific level. The economic incentive structure of adaptation is different and, actually, more favourable than that of mitigation, with respect to both their inter- and intratemporal externalities. The ability to adapt makes a higher level of climate change tolerable. Furthermore, my research shows that adaptation empowers the poor to develop and to enforce a more equitable use of the atmospheric carbon sink; it may potentially also lead to an overall reduction of carbon emissions. Ultimately, it turns out that even in a non-cooperative, asymmetric world, there are prospects for clean technology transfer and adaptation funding. Drawing on the AK growth model with climate change developed by Buckle (2009a,b), the aim of this work is (i) to create a tractable, transparent economic growth model that includes climate damages and emissions abatement, (ii) to develop an adequate analytical representation of adaptation, and (iii) to analyze with the help of game-theoretic methods how the option to undertake adaptation affects the strategic nature of climate negotiations and, in particular, the outcome under a non-cooperative climate change regime.
Two new polyoxomolybdate-based organic–inorganic hybrid compounds with copper ions and bridging ligands
Creators: name: Hao, Xiu-Li
name: Jia, Shi-Fang
name: Wen, Yan-Zhen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Two new polyoxomolybdate-based organic–inorganic hybrid compounds with copper ions and bridging ligands were prepared in a hydrothermal reaction system, and the chemical formulas are [Cu2(L1)4S][Mo6O19] (1) and [CuIICuI2(L2)5][β-Mo8O26] (2) (L1 = 1,2-bis(iminazole-1-ylmethyl)benzene, L2 = 1,4-bis(1,2,4-triazol-1-ylmethyl)benzene). Complexes 1 and 2 were characterized by elemental analysis, IR spectra, TG analyses and single-crystal X-ray diffraction analyses. Compound 1 exhibits 2-D layers with honeycomb-like cavities, further stacking into a 3-D supramolecular framework with the [Mo6O19]2- polyoxoanions as guest templates in the honeycomb-like cavities. Compound 2 possesses an overall 3D(2D/3D) framework constituted by the undulating 2-D motifs and the 3D sqp framework. The photocatalytic activities of 1 and 2 under UV light were investigated based on the degradation of methylene blue (MB). Both compounds exhibit efficient catalytic activity for the degradation of MB.
A stochastic optimization framework for anticipatory transmission investment
Creators: name: Konstantelos, Ioannis
Publisher: name: Imperial College London
Year: 2014

description: An unprecedented amount of renewable generation is to be connected to the UK grid in the coming decades, giving rise to new power flow patterns and warranting unprecedented amounts of transmission investment. However, significant uncertainty surrounds the state of the electricity system, primarily in terms of the size, location and type of new generators to be connected. These sources of uncertainty render the system planner unable to make fully informed decisions about future transmission investment. This thesis presents a stochastic formulation for the transmission expansion planning problem under uncertainty in future generation developments. The problem has been modelled as a multi-stage stochastic optimization problem where the expected system cost is to be minimized. Uncertainty is captured in the form of a multi-stage scenario tree that portrays a range of possible future system states and transition probabilities. A set of investment options with different upgradeability levels and construction times have been included in the formulation to capture the diverse choices present in a realistic setting, where the planner can choose to invest in an anticipatory manner. A novel multi-cut Benders decomposition scheme is used to render the model tractable for large systems with multiple scenarios and operating points. The developed tool can identify the optimal long-term investment strategy based on the triptych of economic efficiency, adequate security provision and acceptable risk. Simulation results on test systems validate that the stochastic approach can lead to further expected cost minimization when compared to methods that ignore the planner’s decision flexibility. Moreover, decisions are taken with subsequent adaptability in mind. The benefit of keeping future expansion options open is properly valued; investment paths that enable future delivery at lower costs are favoured while premature project commitment is avoided.
Well Test Analysis of Infrequent Flow Behaviour of Fractured Wells in Oil and Gas Reservoirs
Creators: name: Amin, Aram
Publisher: name: Imperial College London
Year: 2012

description: The purpose of hydraulic fracturing is to increase the contact area of the wellbore in the reservoir to maximise production rates. For modelling purposes, the induced fracture is assumed to be of infinite or finite conductivity. The modelled fracture tends to show either features of infinite conductivity with half slope or finite conductivity with quarter slope at early time. These flow behaviours are clear indications of a stimulated well. However, observations in some post-frac well tests report a single unit slope in early time, which indicates non-fractured well response. The objective of this study is to investigate the unusual flow behaviour associated with the testing of fractured wells following a proppant frac job and address reasons for this behaviour assuming the frac job has targeted the reservoir interval of interest. This infrequent behaviour is referred to briefly in a limited number of publications but with no clear explanation. Study suggests that the controlling factors are fracture length, fracture conductivity, non-Darcy flow in the case of gas wells and the damage caused by the fracture operation including choked fracture effect and less importantly fracture face skin. This study utilizes 3-D numerical black oil and compositional simulation in single and multi-layered reservoirs containing different fluid types. A range of factors are examined that may impact the introduced fracture flow behaviour based on actual fractured well flow features found in the literature. The main fracture and reservoir parameters investigated include: fracture half-length (xf), fracture conductivity (kfwf), fracture damage including fracture choke (Sfc) and fracture face skin (Sff), non-Darcy effect, formation permeability and many others. The study also examines fractured well behaviour in naturally fractured reservoirs and gas-condensate (lean and rich) reservoirs to investigate liquid drop out effect on the induced fracture flow behaviour. It is concluded that the investigated fracture behaviour is likely to be associated with damaged fractures of short lengths and low fracture conductivity values, which often result from poorly executed frac job on the well. Knowledge obtained from the study is applied to the analysis of well tests from actual fractured wells. Understanding the flow behaviour of fractured wells is crucial to operators and service companies in evaluating the effectiveness of stimulation work performed on the well.
A Modelling Approach To Human Navigation in Constrained Spaces
Creators: name: Desmet, Antoine
Publisher: name: Imperial College London
Year: 2014

description: In this thesis, we consider algorithms and systems which dynamically guide evacuees towards exits during an emergency to minimise building evacuation time. We observe that the "shortest safe path" routing approach is inadequate when congestion is a predominant factor, and therefore focus on systems which manage congestion. We first implement a "Reactive" metric which compares paths based on real-time transit times. We find that regular route corrections must be issued to address the constant changes in path delays, and that routes oscillate. We also implement a model-based "Proactive" metric which forecasts the increase in future congestion that results from every routing decision, allowing the routing algorithm to operate offline. We combine both metrics with the Cognitive Packet Network (CPN), a distributed self-aware routing algorithm which uses neural networks to efficiently explore the building graph. We also present the first thorough sensitivity analysis on CPN's parameters, and use this to tune CPN for optimal performance. We then compare the proactive and reactive approaches through simulation and find both approaches reduce building evacuation times -- especially when evacuees are not evenly distributed in the building. We also find major differences between the Proactive and Reactive approach, in terms of stability, flexibility, sensory requirements, etc. Finally, we consider guiding evacuees using dynamic exit signs, whose pointing direction can be controlled. Dynamic signs can readily be used with Reactive routing, but since Proactive routing issues routes on an individual basis, one display is required for each evacuee. This is incompatible with dynamic signs; therefore we propose a novel algorithm which controls the dynamic signs according to the Proactive algorithm's output. We simulate both systems, compare their performance, and review their practical limitations. For both approaches, we find that updating the sign's display more often improves performance, but this may reduce evacuee compliance and make the system inefficient in real-life conditions.
Scalable Multithreaded Algorithms for Mutable Irregular Data with Application to Anisotropic Mesh Adaptivity
Creators: name: Rokos, Georgios
Publisher: name: Imperial College London
Year: 2014

description: Anisotropic mesh adaptation is a powerful way to directly minimise the computational cost of mesh based simulation. It is particularly important for multi-scale problems where the required number of floating-point operations can be reduced by orders of magnitude relative to more traditional static mesh approaches. Increasingly, finite element/volume codes are being optimised for modern multicore architectures. Inter-node parallelism for mesh adaptivity has been successfully implemented by a number of groups using domain decomposition methods. However, thread-level parallelism using programming models such as OpenMP is significantly more challenging because the underlying data structures are extensively modified during mesh adaptation and a greater degree of parallelism must be realised while keeping the code race-free. In this thesis we describe a new thread-parallel implementation of four anisotropic mesh adaptation algorithms, namely edge coarsening, element refinement, edge swapping and vertex smoothing. For each of the mesh optimisation phases we describe how safe parallel execution is guaranteed by processing workitems in batches of independent sets and using a deferred-operations strategy to update the mesh data structures in parallel without data contention. Scalable execution is further assisted by creating worklists using atomic operations, which provides a synchronisation-free alternative to reduction-based worklist algorithms. Additionally, we compare graph colouring methods for the creation of independent sets and present an improved version which can run up to 50% faster than existing techniques. Finally, we describe some early work on an interrupt-driven work-sharing for-loop scheduler which is shown to perform better than existing work-stealing schedulers. Combining all aforementioned novel techniques, which are generally applicable to other unordered irregular problems, we show that despite the complex nature of mesh adaptation and inherent load imbalances, we achieve a parallel efficiency of 60% on an 8-core Intel(R) Xeon(R) Sandy Bridge and 40% using 16 cores on a dual-socket Intel(R) Xeon(R) Sandy Bridge ccNUMA system.
The Complex Structure of 2D Surfaces
Creators: name: Kawai, H.
name: Tsuda, N.
name: Yukawa, T.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The complex structure of a surface generated by the two-dimensional dynamical triangulation(DT) is determined by measuring the resistivity of the surface. It is found that surfaces coupled to matter fields have well-defined complex structures for cases when the matter central charges are less than or equal to one, while they become unstable beyond c=1. A natural conjecture that fine planar random network of resistors behave as a continuous sheet of constant resistivity is justified numerically for c<1.
description: 4 pages of Latex, 6 Postscript figures(not include Fig.6). Uuencoded and use fleqn.sty, espcrc2.sty and psfig.sty files. Fig.6 available by request from ntsuda@theory.kek.jp, together with a hard copy of the paper. Contribution to Lattice'95
Figure S1 HRMS of Re(CO)3L1 from Synthesis of novel technetium-99 m tricarbonyl-HBED-CC complexes and structural prediction in solution by density functional theory calculation
Creators: name: Shi, Shengyu
name: Yao, Lifeng
name: Li, Linlin
name: Wu, Zehui
name: Zha, Zhihao
name: Kung, Hank F.
name: Zhu, Lin
name: Fang, De-Cai
Publisher: name: The Royal Society
Year: 2019

description: HBED-CC (N,N'-Bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid, L1) is a common bifunctional chelating agent in preparation of 68Ga-radiopharmaceuticals. Due to its high stability constant for the Ga3+ complex (logKGaL = 38.5) and its acyclic structure, it is well known for a rapid and efficient radiolabelling at ambient temperature with Gallium-68 and its high in vivo stability. [99 mTc][Tc(CO)3(H2O)3]+ is an excellent precursor for radiolabelling of biomolecules. The aim of this study was to develop a novel preparation method of 99 mTc-HBED-CC complexes. In this study, HBED-CC-NI (2,2'-(ethane-1,2-diylbis((2-hydroxy-5-(3-((2-(2-nitro-1H-imidazol-1-yl)ethyl)amino)-3-oxopropyl)benzyl)-azanediyl))-diacetic acid, L2), a derivative of HBED-CC, was designed and synthesized. Both L1 and L2 were radiolabelled by [99 mTc][Tc(CO)3(H2O)3]+ successfully for the first time. In order to explore the coordination mode of metal and chelates, non-radioactive Re(CO)3L1 and Re(CO)3L2 were synthesized and characterized spectroscopically. Tc(CO)3L1 and Tc(CO)3L2 in solution were calculated by density functional theory and were analysed with radio-HPLC chromatograms. It showed that [99 mTc]Tc(CO)3L2 forms two stable diastereomers in solution, which is similar to those of [68Ga]Ga-HBED-CC complexes. Natural bond orbital analysis through the natural population charges revealed a charge transfer between [99 mTc][Tc(CO)3]+ and L1 or L2. The experimental results showed that tricarbonyl technetium might form stable complex with HBED-CC derivatives, which is useful for the future application of using HBED-CC as a bifunctional chelating agent in developing new 99 mTc-radiopharmaceuticals as diagnostic imaging agents.
Variability Timescale and Spectral Index of Sgr A* in the Near Infrared: Approximate Bayesian Computation Analysis of the Variability of the Closest Supermassive Black Hole
Creators: name: Witzel, G.
name: Martinez, G.
name: Hora, J.
name: Willner, S. P.
name: Morris, M. R.
name: Gammie, C.
name: Becklin, E. E.
name: Ashby, M. L. N.
name: Baganoff, F.
name: Carey, S.
name: Do, T.
name: Fazio, G. G.
name: Ghez, A.
name: Glaccum, W. J.
name: Haggard, D.
name: Herrero-Illana, R.
name: Ingalls, J.
name: Narayan, R.
name: Smith, H. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Sagittarius A* (Sgr A*) is the variable radio, near-infrared (NIR), and X-ray source associated with accretion onto the Galactic center black hole. We present an analysis of the most comprehensive NIR variability dataset of Sgr A* to date: eight 24-hour epochs of continuous monitoring of Sgr A* at 4.5 $μ$m with the IRAC instrument on the Spitzer Space Telescope, 93 epochs of 2.18 $μ$m data from Naos Conica at the Very Large Telescope, and 30 epochs of 2.12 $μ$m data from the NIRC2 camera at the Keck Observatory, in total 94,929 measurements. A new approximate Bayesian computation method for fitting the first-order structure function extracts information beyond current Fast Fourier Transformation (FFT) methods of power spectral density (PSD) estimation. With a combined fit of the data of all three observatories, the characteristic coherence timescale of Sgr A* is $τ_{b} = 243^{+82}_{-57}$ minutes ($90\%$ credible interval). The PSD has no detectable features on timescales down to 8.5 minutes ($95\%$ credible level), which is the ISCO orbital frequency for a dimensionless spin parameter $a = 0.92$. One light curve measured simultaneously at 2.12 and 4.5 $μ$m during a low flux-density phase gave a spectral index $α_s = 1.6 \pm 0.1$ ($F_ν\propto ν^{-α_s}$). This value implies that the Sgr A* NIR color becomes bluer during higher flux-density phases. The probability densities of flux densities of the combined datasets are best fit by log-normal distributions. Based on these distributions, the Sgr A* spectral energy distribution is consistent with synchrotron radiation from a non-thermal electron population from below 20 GHz through the NIR.
description: Accepted for publication in ApJ on May 30, 2018. A machine readable version of the light curve data is included in the journal's online publication. Version 2 includes proof corrections
Quantum quench dynamics in Dicke superradiance models
Creators: name: Kloc, Michal
name: Stránský, Pavel
name: Cejnar, Pavel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the quantum quench dynamics in an extended version of the Dicke model where an additional parameter allows a smooth transition to the integrable Tavis-Cummings regime. We focus on the influence of various quantum phases and excited-state quantum phase transitions (ESQPTs) on the survival probability of the initial state. We show that, depending on the quench protocol, an ESQPT can either stabilize the initial state or, on the contrary, speed up its decay to the equilibrated regime. Quantum chaos smears out the manifestations of ESQPTs in quench dynamics, therefore significant effects can only be observed in integrable or weakly chaotic settings. Similar features are present also in the post-quench dynamics of some observables.
description: 14 pages, 14 figures
Effect of Crude Oil Vanadyl Porphyrin Content and Blending on Heat Exchanger Fouling
Creators: name: Bin Rostani, Khairul
Publisher: name: Imperial College London
Year: 2013

description: Fouling in the pre-heat train of crude oil distillation unit is a normal occurrence in oil refineries. With the increasing trend of heavy crude oil processing, blending of oils becomes a norm practice in a refinery. Fouling could be enhanced if incompatible oils were blended together. Also, heavy oils typically contain high trace metals composition and their effect towards fouling is yet to be explored. This study has been looking into the effect of changes in the original composition and inter-molecular stability of crude oils towards fouling. A batch system was designed and developed to produce a deposit sample from 3 crude oils of industrial interest. The reactor was successfully commissioned and an operating procedure was established. In the first part of the work, various concentrations of Vanadium were added to crude oils and subjected to high temperature in the test section. The resultant deposits and liquid products were analysed for their molecular structure and weight distribution. Analysis by Inductively Coupled Plasma Mass Spectrometer (ICP-MS) shows the added Vanadium are largely concentrated in the deposits. The amount of deposits produced increases with the concentration of Vanadium in the original samples. Analyses by Size Exclusion Chromatogram (SEC), Gas Chromatography (GC) and UV-Fluorescence Spectroscopy (UVF) show larger and more complex molecules in deposits from oils with high concentration of Vanadium. In the second part, the compatibility regions of crude oil blends were established prior to analysis in the reactor. More deposits were produced from incompatible oil blends though these were lighter and less complex than that of compatible blends. Also, oils that were blended from the incompatible region produced deposits of bigger molecular weight distributions and more complex structures. Results of Thermo-Gravimetric Analysis (TGA) confirmed those of SEC’s and UVF’s of which more volatile components were recorded in active blended deposit samples.
In silico modelling of membranes and drug membrane interactions
Creators: name: Dickson, Callum
Publisher: name: Imperial College London
Year: 2014

description: A new all-atom force field for the simulation of phospholipid bilayers using the AMBER molecular dynamics package has been developed, which is compatible with other AMBER protein, nucleic acid, carbohydrate and small molecule force fields. The force field has been validated by simulating bilayers of six different lipid types, finding favourable comparison to experiment for properties such as area per lipid, volume per lipid, bilayer thickness, NMR order parameters, scattering data, and lipid lateral diffusion. The modular nature of this force field allows numerous combinations of head and tail groups to create different lipid types, enabling the easy insertion of new lipid species. The lipid bilayer model has then been applied to the study of the interaction between radioimaging agents and membranes in an effort to understand the phenomena of non-specific binding, which remains poorly understood yet of serious detrimental consequence to the development of new imaging tracers. The effect of different concentrations of imaging agent on a homogeneous membrane has been examined using unbiased simulations, whilst the permeability coefficient of each imaging agent through a membrane has been calculated using biased simulations. It is found that radiotracers with low non-specific binding must adopt a certain orientation to cross the head group region of a membrane – this requirement may act as a barrier to membrane entry. Furthermore, once partitioned into the membrane, simulations predict that those radiotracers displaying a high degree of non-specific binding act to order lipid tail groups to a greater extent than those with low non-specific binding, reducing the permeability of the membrane and possibly acting to ‘trap’ radiotracer in the membrane. These simulations also predict that non-specific binding is not related to radiotracer membrane permeability through a homogeneous bilayer.
Partition problems in high dimensional boxes
Creators: name: Bucic, Matija
name: Lidicky, Bernard
name: Long, Jason
name: Wagner, Adam Zsolt
Publisher: name: arXiv
Year: 2018
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Alon, Bohman, Holzman and Kleitman proved that any partition of a $d$-dimensional discrete box into proper sub-boxes must consist of at least $2^d$ sub-boxes. Recently, Leader, Milićević and Tan considered the question of how many odd-sized proper boxes are needed to partition a $d$-dimensional box of odd size, and they asked whether the trivial construction consisting of $3^d$ boxes is best possible. We show that approximately $2.93^d$ boxes are enough, and consider some natural generalisations.
description: 19 pages, 10 figures
The effect of fermentable carbohydrate on glucose homeostasis and weight management in people at high-risk of developing diabetes
Creators: name: Guess, Nicola
Publisher: name: Imperial College London
Year: 2014

description: Subjects with prediabetes are at much higher risk of developing diabetes than healthy subjects. Weight loss helps reduce the risk of developing diabetes in these subjects, but long-term weight loss is difficult to achieve due to increases in appetite. Consumption of fermentable carbohydrate has been shown to reduce food intake and body weight, and also improve insulin sensitivity independent of weight loss. Therefore, fermentable carbohydrates may help prevent the development of diabetes in subjects with prediabetes via a two-pronged effect. This thesis comprises three investigations which examine the effects of inulin compared to cellulose control on 1) appetite and food intake, 2) measures of glucose homeostasis and 3) a long-term randomised control trial examining the effect of inulin on weight loss maintenance. In each investigation, subjects take 30g/inulin a day following a 4-week dose-escalation period. In investigations 1 and 2 all subjects take both inulin and cellulose supplements for a 6-week period each, separated by a 4-week wash-out phase. Investigation 3 is a randomised control trial comprising a 9-week weight loss phase, during which participants aim to reach a 5% weight loss at 9 weeks, and a 9-week weight maintenance phase during which subjects are asked to maintain the weight they have lost. In this body of work I demonstrate that inulin reduces appetite, food intake and weight in subjects with prediabetes. I also demonstrate that inulin was significantly associated with an increase in early insulin secretion and GLP-1, potentially due to an improvement in the incretin effect. Inulin also appears to improve insulin sensitivity in subjects with a specific subtype of prediabetes only. Finally, I demonstrate that inulin supplementation results in significantly greater weight loss maintenance, alongside changes in body composition likely to be beneficial long-term.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 0135r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0135r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0135r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux