cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The challenge of skill development through “experiencing” integrated marketing communications
Creators: name: O'Connor, Christina
name: Moran, Gillian
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 3506
subject: Marketing
subject: FOS: Economics and business

description: Purpose – Integrated marketing communications (IMC) is possibly “the richest and most accessible service-learning experience” in the marketing curriculum (Petkus, 2000, p. 68). Yet, despite this recognition, scholars and practitioners continue to lament the pronounced theory-practice gap between how IMC is taught and the practice of it in industry (Schultz and Patti, 2009; Kerr and Kelly, 2017). This research embeds IMC practice within a classroom setting and subsequently explores student marketers’ perceptions of their skill development through experiential client-based learning.
Design/methodology/approach – An in-depth qualitative study demonstrates the value of integrating experiential learning within an IMC course, captured through students’ reflective practice.
Findings – Evidence suggests that experiential, client-based projects are suitable for fostering key practice-based skills in the classroom through students “experiencing” IMC at work. However, this is not always easy.
In fact, building key skills such as leadership, motivation, communications, organisation and teamwork presents various challenges for students, whilst students appear unaware of other pertinent skills (e.g. persuasion, critical thinking) gained through exposure to “real-world” IMC tasks.
Practical implications – Instructors adopting experiential learning in the marketing classroom have an opportunity to actively design tasks to embed key workplace skills to bridge the theory-practice gap. Client-based projects offer fertile ground for students to experience marketing in action whilst ultimately bolstering their confidence in their workplace skills.
Originality/value – This research contributes to the marketing education literature and acknowledges the importance of embedding key workplace skills into the contemporary marketing curriculum. An overview of challenges and solutions for instructors seeking to adopt experiential learning via client-based projects in the IMC classroom is presented within this research.
Ion size effects on the electric double layer of a spherical particle in a realistic salt-free concentrated suspension
Creators: name: Roa, Rafael
name: Carrique, Félix
name: Ruiz-Reina, Emilio
Publisher: name: arXiv
Year: 2011
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A new modified Poisson-Boltzmann equation accounting for the finite size of the ions valid for realistic salt-free concentrated suspensions has been derived, extending the formalism developed for pure salt-free suspensions [Roa et al., Phys. Chem. Chem. Phys., 2011, 13, 3960-3968] to real experimental conditions. These realistic suspensions include water dissociation ions and those generated by atmospheric carbon dioxide contamination, in addition to the added counterions released by the particles to the solution. The electric potential at the particle surface will be calculated for different ion sizes and compared with classical Poisson-Boltzmann predictions for point-like ions, as a function of particle charge and volume fraction. The realistic predictions turn out to be essential to achieve a closer picture of real salt-free suspensions, and even more important when ionic size effects are incorporated to the electric double layer description. We think that both corrections have to be taken into account when developing new realistic electrokinetic models, and surely will help in the comparison with experiments for low-salt or realistic salt-free systems.
description: 12 pages, 7 figures
Itinerant-Electron Magnet of the Pyrochlore Lattice: Indium-Doped YMn2Zn20
Creators: name: Okamoto, Yoshihiko
name: Shimizu, Takeshi
name: Yamaura, Jun-ichi
name: Kiuchi, Yoko
name: Hiroi, Zenji
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report on a ternary intermetallic compound, "YMn2Zn20", comprising a pyrochlore lattice made of Mn atoms. A series of In-doped single crystals undergo no magnetic long-range order down to 0.4 K, in spite of the fact that the Mn atom carries a local magnetic moment at high temperatures, showing Curie-Weiss magnetism. However, In-rich crystals exhibit spin-glass transitions at approximately 10 K due to a disorder arising from the substitution, while, with decreasing In content, the spin-glass transition temperature is reduced to 1 K. Then, heat capacity divided by temperature approaches a large value of 280 mJ K-2 mol-1, suggesting a significantly large mass enhancement for conduction electrons. This heavy-fermion-like behavior is not induced by the Kondo effect as in ordinary f-electron compounds, but by an alternative mechanism related to the geometrical frustration on the pyrochlore lattice, as in (Y,Sc)Mn2 and LiV2O4, which may allow spin entropy to survive down to low temperatures and to couple with conduction electrons.
description: 5 pages, 4 figures, J. Phys. Soc. Jpn., in press
The grainy multiverse
Creators: name: Czech, Bartlomiej
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: I consider a landscape containing three vacua and study the topology of global spacelike slices in eternal inflation. A discrete toy model, which generalizes the well studied Mandelbrot model, reveals a rich phase structure. Novel phases include monochromatic tubular phases, which contain crossing curves of only one vacuum, and a democratic tubular phase, which contains crossing curves of all three types of vacua. I discuss the generalization to realistic landscapes consisting of many vacua. Generically, the system ends up in a grainy phase, which contains no crossing curves or surfaces and consists of packed regions of different vacua. Other topological phases arise on the scale of several generations of nucleations.
description: 16 pages, 7 figures
Partial Schauder estimates for second-order elliptic and parabolic equations
Creators: name: Dong, Hongjie
name: Kim, Seick
Publisher: name: arXiv
Year: 2010
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We establish Schauder estimates for both divergence and non-divergence form second-order elliptic and parabolic equations involving Hölder semi-norms not with respect to all, but only with respect to some of the independent variables.
description: CVPDE, accepted (2010).
Field-tunable stochasticity in the magnetization reversal of a cylindrical nanomagnet
Creators: name: Mukhopadhyay, Soumik
name: Singh, Amrita
name: Ghosh, Arindam
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The nature of magnetization reversal in an isolated cylindrical nanomagnet has been studied employing time-resolved magnetoresistance measurement. We find that the reversal mode is highly stochastic, occurring either by multimode or single-step switching. Intriguingly, the stochasticity was found to depend on the alignment of the driving magnetic field to the long axis of the nanowires, where predominantly multimode switching gives way to single-step switching behavior as the field direction is rotated from parallel to transverse with respect to the nanowire axis.
description: Accepted in Phys. Rev. B
Development of a cheminformatics platform for selectivity analyses of carbonic anhydrase inhibitors
Creators: name: Poli, Giulio
name: Galati, Salvatore
name: Martinelli, Adriano
name: Supuran, Claudiu T.
name: Tuccinardi, Tiziano
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Inorganic Chemistry
subject: Hematology
subject: Plant Biology

description: The selectivity for a specific human Carbonic Anhydrase (hCA) isoform is an important property a hCA inhibitor (CAI) should be endowed with, in order to constitute a valuable therapeutic tool for the treatment of a desired pathology. In this context, we developed a chemoinformatic platform that allows the analysis of the structure and selectivity profile of known CAIs reported in literature, with the aim of identifying structural motifs connected to ligand selectivity, thus providing useful guidelines for the design of novel ligands selective for the desired hCA isoform. The platform is able to perform ultrafast structure and selectivity analyses through ligand fingerprint similarity, with no need of structural information about the target receptor and ligands’ binding mode. It is easily accessible to the non-expert user through the implementation of a KNIME Analytic Platform workflow and could be extended to analyze the selectivity profile of known ligands of different target proteins.
Rotating Shallow Water Dynamics: Extra Invariant and the Formation of Zonal Jets
Creators: name: Balk, Alexander M.
name: van Heerden, Francois
name: Weichman, Peter B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Other Condensed Matter (cond-mat.other)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We show that rotating shallow water dynamics possesses an approximate (adiabatic-type) positive quadratic invariant, which exists not only at mid-latitudes (where its analogue in the quasigeostrophic equation has been previously investigated), but near the equator as well (where the quasigeostrophic equation is inapplicable). Deriving the extra invariant, we find "small denominators" of two kinds: (1) due to the triad resonances (as in the case of the quasigeostrophic equation) and (2) due to the equatorial limit, when the Rossby radius of deformation becomes infinite. We show that the "small denominators" of both kinds can be canceled. The presence of the extra invariant can lead to the generation of zonal jets. We find that this tendency should be especially pronounced near the equator. Similar invariant occurs in magnetically confined fusion plasmas and can lead to the emergence of zonal flows.
description: 29 pages, 4 figures
Piezoelectricity in the dielectric component of nanoscale dielectric/ferroelectric superlattices
Creators: name: Jo, Ji Young
name: Sichel, Rebecca J.
name: Lee, Ho Nyung
name: Nakhmanson, Serge M.
name: Dufresne, Eric M.
name: Evans, Paul G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The origin of the functional properties of complex oxide superlattices can be resolved using time-resolved synchrotron x-ray diffraction into contributions from the component layers making up the repeating unit. The CaTiO3 layers of a CaTiO3/BaTiO3 superlattice have a piezoelectric response to an applied electric field, consistent with a large continuous polarization throughout the superlattice. The overall piezoelectric coefficient at large strains, 54 pm/V, agrees with first-principles predictions in which a tetragonal symmetry is imposed on the superlattice by the SrTiO3 substrate.
description: 4 figures
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
Creators: name: Corrigan, Thomas S.
name: Diaz, Leilani M. Lotti
name: Border, Sarah E.
name: Ratigan, Steven C.
name: Kasper, Kayla Q.
name: Sojka, Daniel
name: Fajtova, Pavla
name: Caffrey, Conor R.
name: Salvesen, Guy S.
name: McElroy, Craig A.
name: Hadad, Christopher M.
name: Ekici, Özlem Doğan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases. We designed and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like active site of the proteasome, aza-Asp derivatives that were effective inhibitors of caspases-3 and -6, and aza-Asn derivatives that inhibited S. mansoni and I. ricinus legumains. The crystal structure of caspase-3 in complex with our caspase-specific aza-peptide methyl ketone inhibitor with an aza-Asp residue at P1 revealed a covalent linkage between the inhibitor carbonyl carbon and the active site cysteinyl sulphur. Aza-peptide aldehydes and ketones showed no cross-reactivity towards cathepsin B or chymotrypsin. The initial in vitro selectivity of these inhibitors makes them suitable candidates for further development into therapeutic agents to potentially treat multiple myeloma, neurodegenerative diseases, and parasitic infections.
Neutron stars with small radii -- the role of delta resonances
Creators: name: Schürhoff, Torsten
name: Schramm, Stefan
name: Dexheimer, Veronica
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Recent neutron star observations suggest that the masses and radii of neutron stars may be smaller than previously considered, which would disfavor a purely nucleonic equation of state. In our model, we use a the flavor SU(3) sigma model that includes delta resonances and hyperons in the equation of state. We find that if the coupling of the delta resonances to the vector mesons is slightly smaller than that of the nucleons, we can reproduce both the measured mass-radius relationship and the extrapolated equation of state.
description: 4 pages, 4 figures
Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates
Creators: name: Küçükbay, Hasan
name: Buğday, Nesrin
name: Küçükbay, F. Zehra
name: Ageli, Andrea
name: Bartolucci, Gianluca
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: A series of amino acid–sulphonamide conjugates was prepared through benzotriazole mediated coupling reactions and characterised by 1H-NMR, 13C-NMR, MS, and FTIR spectroscopic techniques as well as elemental analysis. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of the new compounds was determined against four human (h) isoforms, hCA I, hCA II, hCA VA, and hCA XII. Most of the synthesised compounds showed effective in vitro CA inhibitory properties. The new amino acid–sulphonamide conjugates showed potent inhibitory activity against hCA II, some of them at subnanomolar levels, exhibiting more effective inhibitory activity compared to the standard drug acetazolamide. Some of these sulphonamides were also found to be effective inhibitors of hCA I, hCA VA, and hCA XII, with activity from the low to high nanomolar range.
Usability evaluation of emerging virtual reality technologies in telerobotics
Creators: name: Haghjoo, Fatemeh
Publisher: name: University of British Columbia
Year: 2018

description: Recent technological advancements in robotic systems have led to increasing exposure of humans to these systems. Therefore, the quality of Human-Robot Interactions (HRI), which effect adoption of robots by human operators, is increasingly important [1]. This is particularly true in telerobotic applications, where users can only operate a robot remotely and a problematic interface can have major implications. Therefore, the objective of this study is to investigate whether using a head-mounted display and a hand-tracking device in the development of HRI systems can result in better interactions. Hence, usability testing was performed via user studies considering three factors: effectiveness, efficiency, and user satisfaction. Three different HRI modes were developed: manual, Virtual Reality (VR), and Mixed Reality (MR). The manual mode involved manual control of a robotic arm using a keyboard with visual feedback on a monitor. The VR mode entailed controlling the robotic arm by hand gestures using Leap Motion and visual feedback from a VR environment provided through Oculus Rift. The MR mode was similar to the VR, but the visual feedback was augmented with views from two cameras provided to the user through Oculus Rift. These modes were used to perform a pick-and-place task. Effectiveness was evaluated by measuring the success rates of each mode and performing an error analysis; efficiency was examined by considering the time-of-completion; and user satisfaction was subjectively measured using a Likert-type questionnaire. Statistical analysis revealed that the VR mode was the most efficient and effective and also resulted in fewer human and system errors. Users' gaming experience was also considered as a factor, but had no effect on the effectiveness or efficiency of any mode. Therefore, it is concluded that users require no prior experience, and consequently training, to achieve effective and efficient HRI using this mode. Moreover, the questionnaire revealed that users were highly satisfied with both VR and MR modes, with no clear preference. To conclude, the application of Oculus Rift and Leap Motion results in more effective and efficient HRI, and is recommended for use in real-world applications similar to pick-and place tasks, such as in the manufacturing industry.
Female entrepreneurs need to be self-efficient and not risk-taking: personality and perceived success throughout the entrepreneurial journey
Creators: name: Gerke, Alina
name: Ianiro-Dahm, Patrizia
name: Muck, Peter
name: Lehmann-Willenbrock, Nale
name: Hell, Benedikt
Publisher: name: SAGE
Year: 2023
Subjects: subject: 330 - Wirtschaft
subject: 150 - Psychologie

description: This study addresses the underrepresentation of women and the so-far neglected process perspective in empirical entrepreneurial research. It aims to identify the personality traits that differentiate successful female entrepreneurs from their less successful peers and to determine which traits are crucial for pre-launch, launch, and post-launch success. Independent t-tests on 305 female entrepreneurs (and 476 male entrepreneurs) from the DACH region highlight the role of self-efficacy, proactivity, locus of control, and need for achievement for female entrepreneurs. Multiple regression analyses further reveal the importance of self-efficacy for every phase of women’s entrepreneurial journey. While the need for autonomy was critical during pre-launch and launch, locus of control significantly predicted female entrepreneurial success in the pre-launch and post-launch phases. Contrary to previous research, risk-taking was not a crucial trait for female entrepreneurs when compared to their male counterparts, while both showed similar levels of need for autonomy, proactivity, need for achievement, perseverance, self-control, and locus of control. The study offers valuable insights into successful entrepreneurship and highlights the need for female- and phase-specific support programs to enhance self-efficacy among female entrepreneurs.
Raman spectroscopy on etched graphene nanoribbons
Creators: name: Bischoff, Dominik
name: Güttinger, Johannes
name: Dröscher, Susanne
name: Ihn, Thomas
name: Ensslin, Klaus
name: Stampfer, Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate etched single-layer graphene nanoribbons with different widths ranging from 30 to 130 nm by confocal Raman spectroscopy. We show that the D-line intensity only depends on the edge-region of the nanoribbon and that consequently the fabrication process does not introduce bulk defects. In contrast, the G- and the 2D-lines scale linearly with the irradiated area and therefore with the width of the ribbons. We further give indications that the D- to G-line ratio can be used to gain information about the crystallographic orientation of the underlying graphene. Finally, we perform polarization angle dependent measurements to analyze the nanoribbon edge-regions.
Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro
Creators: name: Jo, Seri
name: Kim, Suwon
name: Kim, Dae Yong
name: Kim, Mi-Sun
name: Shin, Dong Hae
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the termination is not yet predictable. Currently, researches to develop vaccines and treatments is going on globally to cope with this disastrous disease. Main protease (3CLpro) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the good targets to find antiviral agents before vaccines are available. Some flavonoids are known to inhibit 3CLpro from SARS-CoV which causes SARS. Since their sequence identity is 96%, a similar approach was performed with a flavonoid library. Baicalin, herbacetin, and pectolinarin have been discovered to block the proteolytic activity of SARS-CoV-2 3CLpro. An in silico docking study showed that the binding modes of herbacetin and pectolinarin are similar to those obtained from the catalytic domain of SARS-CoV 3CLpro. However, their binding affinities are different due to the usage of whole SARS-CoV-2 3CLpro in this study. Baicalin showed an effective inhibitory activity against SARS-CoV-2 3CLpro and its docking mode is different from those of herbacetin and pectolinarin. This study suggests important scaffolds to design 3CLpro inhibitors to develop antiviral agents or health-foods and dietary supplements to cope with SARS-CoV-2.
Projectile's mass, reactivity and molecular dependence on ion nanostructuring
Creators: name: Bhattacharjee, S.
name: Karmakar, P.
name: Sinha, A. K.
name: Chakrabarti, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have reported the dependence of projectile mass along with the chemical reactivity and nonlinear effects on ion beam induced nano structure formation when 8 keV He1+, N1+, O1+, Ar1+ atomic ions and 16 keV N21+ and O21+ molecular ions are bombarded on the Si (100) surface at an incidence angle of 600. Ex situ atomic force microcopy (AFM) measurements reveals the ripple structure development of various forms and dimensions depending on the projectiles mass, chemical reactivity and molecular state. This experimental study explores the necessary requirements for ion induced nanopatterning and their control.
Deliverable: D6.1 – Data Hub
Creators: name: Jean-Francois Perrin
name: La Rocca, Giuseppe
Publisher: name: Zenodo
Year: 2022

description: The work of WP6 concerning data transfer is driven by 3 different uses cases where we try to explore the technical solutions available today, to understand their limits and how they could be integrated in the RIs ecosystem (technical integration, sustainability, investment and operational cost, support organisation, etc.): A RI wants to archive its experimental data in a remote data centre. A user wants to access a data analysis service, data has to be available “transparently”. A facility user wants to transfer a large dataset from an RI’s archive to a remote compute centre or her or his home pc. In the work related to this deliverable, the 2nd use case where a scientist wants to access a data analysis service offered by another organisation has been explored. The compute resources, where the service lives, are distant from the RI archive holding the data.
Parallaxes of Southern Extremely Cool objects - I: Targets, Proper motions and first results
Creators: name: Andrei, Alexandre H.
name: Smart, Richard L.
name: Penna, Jucira L.
name: d'Avila, Victor A.
name: Bucciarelli, Beatrice
name: Camargo, Julio I. B.
name: Crosta, Maria Teresa
name: Dapra, Mario
name: Goldman, Bertrand
name: Jones, Hugh R. A.
name: Lattanzi, Mario G.
name: Nicastro, Luciano
name: Neto, Dario N. da Silva
name: Teixeira, Ramachrisna
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present results from the PARallaxes of Southern Extremely Cool objects (PARSEC) program, an observational program begun in April 2007 to determine parallaxes for 122 L and 28 T southern hemisphere dwarfs using the Wide Field Imager on the ESO 2.2m telescope. The results presented here include parallaxes of 10 targets from observations over 18 months and a first version proper motion catalog. The proper motions were obtained by combining PARSEC observations astrometrically reduced with respect to the UCAC2 Catalog, and the 2MASS Catalog. The resulting median proper motion precision is 5mas/yr for 195,700 sources. The 140 0.3deg2 fields sample the southern hemisphere in an unbiased fashion with the exception of the galactic plane due to the small number of targets in that region. We present preliminary parallaxes with a 4.2 mas median precision for 10 brown dwarfs, 2 of which are within 10pc. These increase by 20% the present number of L dwarfs with published parallaxes. Of the 10 targets, 7 have been previously discussed in the literature: two were thought to be binary but the PARSEC observations show them to be single, one has been confirmed as a binary companion and another has been found to be part of a binary system, both of which will make good benchmark systems. Observations for the PARSEC program will end in early 2011 providing 3-4 years of coverage for all targets. The main expected outputs are: more than a 100% increase of the number of L dwarfs with parallaxes; to increment - in conjuction with published results - to at least 10 the number of objects per spectral subclass up to L9, and; to put sensible limits on the general binary fraction of brown dwarfs. We aim to contribute significantly to the understanding of the faint end of the H-R diagram and of the L/T transition region.
description: Subnmitted to Astronomical Journal
Design, synthesis, and evaluation of novel N'-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents
Creators: name: Le Cong Huan
name: Anh, Duong Tien
name: Hai, Pham-The
name: Anh, Lai Duc
name: Park, Eun Jae
name: Ji, A Young
name: Kang, Jong Soon
name: Dung, Do Thi Mai
name: Oanh, Dao Thi Kim
name: Tung, Truong Thanh
name: Hai, Dinh Thi Thanh
name: Han, Sang-Bae
name: Nam, Nguyen-Hai
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: In continuity of our search for novel anticancer agents acting as procaspase activators, we have designed and synthesised two series of (E)-N′-benzylidene-carbohydrazides (4a–m) and (Z)-N'-(2-oxoindolin-3-ylidene)carbohydrazides (5a–g) incorporating 1-(4-chlorobenzyl)-1H-indole core. Bioevaluation showed that the compounds, especially compounds in series 4a–m, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer). Within series 4a–m, compounds with 2-OH substituent (4g–i) exhibited very strong cytotoxicity in three human cancer cell lines assayed with IC50 values in the range of 0.56–0.83 µM. In particular, two compounds 4d and 4f bearing 4-Cl and 4-NO2 substituents, respectively, were the most potent in term of cytotoxicity with IC50 values of 0.011–0.001 µM. In caspase activation assay, compounds 4b and 4f were found to activate caspase activity by 314.3 and 270.7% relative to PAC-1. This investigation has demonstrated the potential of these simple acetohydrazides, especially compounds 4b, 4d, and 4f, as anticancer agents.
Archäoprognose in Schleswig-Holstein
Creators: name: Mennenga, Moritz
Publisher: name: Zenodo
Year: 2016
Subjects: Archaeology
Predictive Modelling
Neolithic
Germany

description: This is the slightly amended version of the authors Diplom-thesis in prehistoric archaeology. In the region of Eastern Holstein in Northern Germany a large amount of neolithic surface finds leading to potential settlements or burials. By using the data of the archäologische Landesaufnahme it was possible to date the sites and classify them. This data was used to do a predictive modelling by using a logistic regression analysis.
Loose mechanochemical coupling of molecular motors
Creators: name: Zhang, Yunxin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: In living cells, molecular motors convert chemical energy into mechanical work. Its thermodynamic energy efficiency, i.e. the ratio of output mechanical work to input chemical energy, is usually high. However, using two-state models, we found the motion of molecular motors is loosely coupled to the chemical cycle. Only part of the input energy can be converted into mechanical work. Others is dissipated into environment during substeps without contributions to the macro scale unidirectional movement.
GRBs in the SWIFT and Fermi era: a new view of the prompt emission
Creators: name: Massaro, F.
name: Grindlay, J. E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Gamma Ray Bursts (GRBs) show evidence of different light curves, duration, afterglows, host galaxies and they explode within a wide redshift range. However, their spectral energy distributions (SEDs) appear to be very similar showing a curved shape. In 1993 Band et al. proposed a phenomenological description of the integrated spectral shape for the GRB prompt emission, the so called Band function. We present an alternative scenario to explain the curved shape of GRB SEDs: the log-parabolic model.
description: 4 pages, 4 figures, prroceedings of the "GRBs 2010" conference in Annapolis (MD-USA)
The medium is the massacre : broadcasting from the apocalypse in The War of the Worlds
Creators: name: De Santis, Michael
Publisher: name: University of British Columbia
Year: 2018

description: In this thesis, I discuss the 1938 radio play The War of the Worlds, analyzing the circumstances of its broadcast, its representation of apocalypse, and its manipulation of the medium of radio through its form of a simulated news program. I propose that the immediate hysteria it caused and the enduring anxieties it left were because of its medium more than any verisimilitude achieved in its tired and recycled narrative of Martian invasion. I consider qualities of radio as a telecommunicative and single-sensory medium, the demands of apocalyptic representation, and how the broadcast manipulated these qualities of radio to satisfy these representational demands, thus portraying an account of simulated apocalypse that was, on a formal and medial level, indistinguishable from a real one over the radio. Borrowing from the work of Richard Berger, I discuss how apocalyptic representation must occur immediately and immanently with the apocalypse itself; that is, the representation must be separated neither by time nor space with what it represents, right until the annihilating end. While many media cannot facilitate these demands of apocalyptic representation, instead reverting to prophetic or post-apocalyptic representation, I suggest that telecommunicative media are able to navigate the demands of truly apocalyptic representation through their overcoming of spatial separation and temporal delay. Working with the theory of Andrew Crisell, I consider the single-sensory nature of the medium of radio, and its propensity to render real and imaginary events indistinguishable. As a purely acoustic medium, radio necessarily incites an indexical process while simultaneously prohibiting its completion. Because radio prohibits the ability to index a sound with a particular source, and its specific temporal and spatial location, it creates a level playing field for reality and simulation where the two cannot be differentiated. As such, broadcast sounds become untethered from their particular source, ungrounded in time, space, and even reality. Thus, War was able to represent a simulated apocalypse indiscernible from a real one because of the single-sensory nature of radio, and satisfy the demands of apocalyptic representation with the immanency and immediacy inherent to the telecommunicative medium of its broadcast.
title: Technologien des Glaubens: Schubkräfte zwischen technologischen Entwicklungen und religiösen Diskursen : Tagung veranstaltet vom Landesforschungsschwerpunkt „Aufklärung – Religion – Wissen“ der Martin-Luther-Universität Halle-Wittenberg in Kooperation mit den Franckeschen Stiftungen und der Deutschen Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften 24. – 26. September 2015 in Halle (Saale)
Creators: name: :None
Publisher: name: Wissenschaftliche Verlagsgesellschaft Stuttgart
Year: 2017
Subjects: subject: Technologie
subject: Religion
subject: Glaube
subject: Weltanschauung
subject: Wissenschaftsgeschichte
subject: 000
subject: 600
subject: 200

description: Religion und rational verstandene Wissenschaft und Technik scheinen streng getrennte Bereiche. Die Wissenschafts- und Technikgeschichte zeigt bei gründlicher Analyse aber, dass Gläubige und Glaubensgemeinschaften in verschiedenen Zeiten immer wieder bestrebt waren, rationales Wissen und daraus entwickelte Technologie und Techniken in ihr Weltbild zu integrieren bzw. innerhalb ihrer Weltsicht zu interpretieren und es dann sogar für ihre Zwecke in den Dienst zu nehmen. In den archaischen Religionen galten Technologien als göttlichen Ursprungs, und bis in die Moderne hinein finden sich bemerkenswerte Fälle einer positiven Aneignung neuer Technologien durch religiöse Gemeinschaften. Der vorliegende Band versammelt Beiträge zu diesen positiven Kontinuitäten zwischen Religionen und Technologien seit der Frühen Neuzeit. Sie verweisen auf die sich seitdem verdichtenden religiösen Diskurse und deren Akteure, die sich um eine Integration der technischen Innovationen in den metaphysischen Rahmen des Glaubens bemühen. Die Beispiele widerlegen eine ausschließlich fortschreitende Verdrängung der Religion durch Wissenschaft, sondern zeichnen ein wesentlich differenzierteres Bild, indem die Warner- und Begrenzerattitüde, die oft als gängiges Klischee für das Verhältnis von Religion zur Technik gebraucht wird, durch mannigfaltigere Perspektiven zu ersetzen ist.
description: Acta historica Leopoldina, vol. 71
Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane
Creators: name: Cirigliano, Angela
name: Amelina, Antonia
name: Biferali, Beatrice
name: Macone, Alberto
name: Mozzetta, Chiara
name: Bianchi, Michele Maria
name: Mori, Mattia
name: Botta, Bruno
name: Pick, Elah
name: Negri, Rodolfo
name: Rinaldi, Teresa
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medical use, yet statins treatment could induce side effects as hepatotoxicity and myopathy in patients. We used Saccharomyces cerevisiae as a model to investigate the effects of statins on mitochondria. We demonstrate that statins are active in S.cerevisiae by lowering the ergosterol content in cells and interfering with the attachment of mitochondrial DNA to the inner mitochondrial membrane. Experiments on murine myoblasts confirmed these results in mammals. We propose that the instability of mitochondrial DNA is an early indirect target of statins.
Auf der Suche nach der Trichterbecherkultur / Op zoek naar de trechterbekercultuur
Creators: name: Jöns, Hauke
name: Groenendijk, Henny
name: Raemaekers, Daan
name: Kegler, Jan
name: Mennenga, Moritz
name: Nösler, Daniel
Publisher: name: Zenodo
Year: 2013
Subjects: Single Grave Culture
TRB Culture
Funnelbeaker
Trichterbecher
Swifterband

description: Bi-lingual (Dutch-German) overview of the TRB culture in the northern Netherlands and adjacent Lower Saxony. Part of the exhibition catalogue 'Land of Discoveries'.
D9.5 Feasibility report on setting up a collection on questionnaires relating to Ethnic and Migrant Minorities in the European Question Bank
Creators: name: Morales, Laura
name: Saji, Ami
name: Winn, Meredith
Publisher: name: Zenodo
Year: 2021
Subjects: SSHOC
Social Sciences and Humanities Open Cloud
European Open Science Cloud
EOSC
survey data
Ethnic and migrant minority
ETHMIGSURVEYDATA
EMM

description: This document is a deliverable of the Social Sciences and Humanities Open Cloud (SSHOC) project. It is a report assessing the feasibility of setting up, as part of the CESSDA ERIC-led European Question Bank (EQB), a collection dedicated to the questionnaires and question items included in quantitative surveys on Ethnic and Migrant Minorities’ (EMMs’) inclusion and/or integration identified as part of the creation of the EMM Survey Registry (i.e. the SSHOC Deliverable 9.4 Database with the metadata of surveys to EMMs across Europe1). As such, the main aim of this report is to provide a detailed account of how the ethnic and migration studies data community—i.e. the team of Task 9.2 Ethnic and Migrant Studies of Work Package 9 Data Communities of SSHOC, COST Action 16111 - ETHMIGSURVEYDATA, and the French Open Science project, FAIRETHMIGQUANT—critically examined the realities of being able to create an EMM collection for the EQB. The report begins by illustrating how the FAIR principles, as well as the cumulative experience in developing the EMM Survey Registry, led to the EMM collection for the EQB being conceptualized as a standalone service, the EMM Question Data Bank (QDB) from which the EQB would be able to ingest the questionnaires of the EMM surveys. It then describes the key challenges identified in setting up the conceptualized EMM collection and the subsequent solutions to these challenges, which in turn helped create workflows for creating an EMM collection. It concludes with a reflection of the overall assessment process, undertaken by the ethnic and migration studies data community, where the argument is made that an EMM collection for the EQB can be constructed, but with careful consideration of the budgetary, human resources, and technical demands of creating such an innovative and novel resource, as well as the sustainability and durability of the linkage between the EMM QDB and the EQB.
Low energy ($p,γ$) reactions in Ni and Cu nuclei using microscopic optical model
Creators: name: Gangopadhyay, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Radiative capture reactions for low energy protons have been theoretically studied for Ni and Cu isotopes using the microscopic optical model. The optical potential has been obtained in the folding model using different microscopic interactions with the nuclear densities from Relativistic Mean Field calculations. The calculated total cross sections as well as the cross sections for individually low lying levels have been compared with measurements involving stable nuclear targets. Rates for the rapid proton capture process have been evaluated for astrophysically important reactions.
description: To appear in Physical Review C
Modeling the formation and evolution of star cluster populations in galaxy simulations
Creators: name: Kruijssen, J. M. Diederik
name: Pelupessy, F. Inti
name: Lamers, Henny J. G. L. M.
name: Zwart, Simon F. Portegies
name: Icke, Vincent
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: (Abridged) The formation and evolution of star cluster populations are related to the galactic environment. Cluster formation is governed by processes acting on galactic scales, and star cluster disruption is driven by the tidal field. In this paper, we present a self-consistent model for the formation and evolution of star cluster populations, for which we combine an N-body/SPH galaxy evolution code with semi-analytic models for star cluster evolution. The model includes star formation, feedback, stellar evolution, and star cluster disruption by two-body relaxation and tidal shocks. We apply the model by simulating a suite of 9 isolated disc galaxies and 24 galaxy mergers. The evolutionary histories of individual clusters in these simulations are discussed to illustrate how the environment of clusters changes in time and space. The resulting variability of the disruption rate with time and space affects the properties of star cluster populations. The combined effect of clusters escaping their dense formation sites (`cluster migration') and the preferential disruption of clusters residing in dense environments (`natural selection') implies that the mean disruption rate of the population decreases with cluster age. This affects the slope of the cluster age distribution, which becomes a function of the star formation rate density. The evolutionary histories of clusters in a galaxy merger vary widely and determine which clusters survive the merger. This impacts the age distributions and the locations of the surviving clusters at all times during a merger. We conclude that accounting for the interplay between the formation, disruption, and orbital histories of clusters enables a more sophisticated interpretation of observed properties of cluster populations, thereby extending the role of cluster populations as tracers of galaxy evolution.
description: 28 pages, 18 figures, 2 tables; Accepted for publication in MNRAS
Magnetoresistance and Magnetic Ordering Fingerprints in Hydrogenated Graphene
Creators: name: Soriano, David
name: Leconte, Nicolas
name: Ordejón, Pablo
name: Charlier, Jean-Christophe
name: Palacios, Juan José
name: Roche, Stephan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin-dependent features in the conductivity of graphene, chemically modified by a random distribution of hydrogen adatoms, are explored theoretically. The spin effects are taken into account using a mean-field self-consistent Hubbard model derived from first-principles calculations. A Kubo-Greenwood transport methodology is used to compute the spin-dependent transport fingerprints of weakly hydrogenated graphene-based systems with realistic sizes. Conductivity responses are obtained for paramagnetic, antiferromagnetic, or ferromagnetic macroscopic states, constructed from the mean-field solutions obtained for small graphene supercells. Magnetoresistance signals up to $\sim 7%$ are calculated for hydrogen densities around 0.25%. These theoretical results could serve as guidance for experimental observation of induced magnetism in graphene.
description: 4 pages, 4 figures
2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors
Creators: name: Lamie, Phoebe F.
name: Philoppes, John N.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77–1.74 µM, against K-562 cell line), 9a and 9r (IC50=1.37–3.56 µM against MCF-7 cell line), and 9a, 9l, and 9n (IC50=2.10 and 2.37 µM against HT-29 cell line). Compounds 9a, 9d, 9f, 9n, and 9r were further evaluated for their cytotoxicity against normal fibroblast cell line WI38. Moreover, STAT3 and STAT5a inhibitory activities were determined for the most active derivatives 9a, 9d, 9f, 9n, and 9r. Dual inhibitory activity was observed in compound 9n (IC50=113.31 and 50.75 µM, against STAT3 and STAT5a, respectively). Prediction of physicochemical properties, drug likeness score, pharmacokinetic and toxic properties was detected.