cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of quark-matter symmetry energy on hadron-quark coexistence in neutron-star matter
Creators: name: Wu, Xuhao
name: Ohnishi, Akira
name: Shen, Hong
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We examine the effects of the isovector-vector coupling and hypercharge-vector coupling in quark matter on hadron-quark coexistence in neutron-star matter. The relativistic mean field theory with the TM1 parameter set and an extended TM1 parameter set are used to describe hadronic matter, and the Nambu-Jona-Lasinio model with scalar, isoscalar-vector, isovector-vector and hypercharge-vector couplings is used to describe deconfined quark matter. The hadron-quark phase transition is constructed via the Gibbs conditions for phase equilibrium. The isovector-vector and hypercharge-vector couplings in quark matter enhance the symmetry energy and hypercharge symmetry energy in neutron-star matter, while their effects are found to be suppressed at high densities by the strange quarks. As a result, the hadron-quark mixed phase shrinks with only isovector-vector coupling and moves to higher density with isovector-vector and hypercharge-vector couplings. The maximum mass of neutron-star increases slightly with isovector-vector and hypercharge-vector couplings.
description: 9 pages, 7 figures
MOESM10 of Genetic repertoires of anaerobic microbiomes driving generation of biogas
Creators: name: Grohmann, Anja
name: Yevhen Vainshtein
name: Euchner, Ellen
name: Grumaz, Christian
name: Bryniok, Dieter
name: Rabus, Ralf
name: Sohn, Kai
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: Additional file 10. Heatmap of log2-transformed RPKM values of enzymes associated with methanogenesis.
Simia satyrus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Atelidae
Simia
Simia satyrus

description: Simia satyrus [spec. nov.]
S. ecaudata subtus nuda. Syst. nat. VI. p. 3.
Satyrus indicus. Tulp. obs. III. c. 56.
Habitat in Africa, Asia.
Magnitudo pueri sexennis. Dorsum crinibus nigris hirsutum, subtus s. antice undique glaber.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 25, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Investigating heterotopic bone behaviour through the development of a finite element model
Creators: name: Rosenberg, Naomi
Publisher: name: Imperial College London
Year: 2017

description: Heterotopic ossification (HO) is the formation of mature lamellar bone in tissues that are not usually osseous. It is a significant risk in blast-related injuries and is seen in approximately 60% of UK military blast-related amputees. HO can result in reduced range of motion, pain, nerve impingement and can affect prosthesis fitting. The causes of HO are due to a mix of mechanical and biological, local and systemic factors. However, as with normal bone formation and remodelling, it may be expected that heterotopic bone also responds to mechanical stimuli to an extent. Understanding this relationship further can give insight into possible ways to manipulate the progression of HO and prevent complications in the future. The objective of this research is to create a mechanically driven physiological computational model of HO in the residual limb of a trans-femoral amputee. The current work involved expanding upon previously proposed finite element bone remodelling algorithms in the literature for the application of heterotopic remodelling in soft tissue. This study introduced an extra factor to represent the tendency for soft tissue to calcify. This factor increases in magnitude with proximity to a specified wound site and with tissue strain. Initially, soft tissue is modelled as hypoelastic with a much lower stiffness to bone. If the density in a soft tissue element exceeds a certain threshold, the material properties of the element are redefined to become proportional to the density alike bone. These newly recruited bone elements make up the projected heterotopic bone geometry. The different parameters within the algorithm were adjusted to examine their effect on the final outcome of heterotopic bone geometry. With consideration to their effects, loading was found to significantly alter the geometry of HO. Certain characteristic appearances of HO outlined in the literature were reproduced by adjusting the loading environment.
Memory effects in the Fermi-Pasta-Ulam Model
Creators: name: Amati, Graziano
name: Meyer, Hugues
name: Schilling, Tanja
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study the Intermediate Scattering Function (ISF) of the strongly-nonlinear Fermi-Pasta Ulam Model at thermal equilibrium, using both numerical and analytical methods. From the molecular dynamics simulations we distinguish two limit regimes, as the system behaves as an ideal gas at high temperature and as a harmonic chain for low excitations. At intermediate temperatures the ISF relaxes to equilibrium in a nontrivial fashion. We then calculate analytically the Taylor coefficients of the ISF to arbitrarily high orders (the specific, simple shape of the two-body interaction allows us to derive an iterative scheme for these.) The results of the recursion are in good agreement with the numerical ones. Via an estimate of the complete series expansion of the scattering function, we can reconstruct within a certain temperature range its coarse-grained dynamics. This is governed by a memory-dependent Generalized Langevin Equation (GLE), which can be derived via projection operator techniques. Moreover, by analyzing the first series coefficients of the ISF, we can extract a parameter associated to the strength of the memory effects in the dynamics.
Fluorination as a tool for controlling properties, molecular order and functionality of polythiophene derivatives
Creators: name: Boufflet, Pierre
Publisher: name: Imperial College London
Year: 2016

description: In this work, we explore the uses of fluorination in the context of π-conjugated polymers. Using extensively studied model systems such as poly(3-hexylthiophene) (P3HT) and poly(2,5-bis(3- alkylthiophen-2-yl)thieno[3,2-b]thiophene) (PBTTT), we are able to probe the influence of thiophene fluorination on the electronic structure and thin-film morphology, two defining aspects of organic semiconductor performance in electronic devices such as organic field effect transistors (OFET). Experimental data obtained from Ultraviolet photoelectron, UV-Visible and Raman spectroscopy along with differential scanning calorimetry, atomic force microscopy and X-ray diffraction suggest that fluorination leads to a stabilisation of the frontier molecular orbital levels and increased backbone planarity. The latter manifest itself as an enhanced propensity to aggregate and much higher melting point. Hole carrier mobilities in OFET devices are considerably enhanced in the backbone-fluorinated polymers, an observation attributed to the increased planarity of the polymer backbone. Computational calculations also predict an increased backbone rigidity and a strong preference for the coplanar arrangement of fluorinated thiophene rings. The origins of such planarisation are thought to be intramolecular in nature, likely from sulfur-fluorine inter-ring interactions as evidenced by S-F short contacts observed in the single crystal X-ray structure of a bithiophene monomer precursor. By synthesising well-defined diblock and alternating copolymers, backbone fluorination is then explored as a potential tool to control phase separation and dielectric constants, two key factors involved in the context of organic photovoltaic (OPV) devices. The utility of fluorine atoms as a good leaving-group in nucleophilic aromatic displacements on electron-poor aromatic systems is then used to produce a P3HT derivative end-capped with pentafluorobenzene. This polymer can then be reacted with good nucleophiles in mild conditions. As a proof of concept, three functional moieties are tethered to the P3HT derivative in this manner, opening the door towards sensing applications and hybrid organic/inorganic semiconductor interface engineering.
Novel transmission and beamforming strategies for multiuser MIMO with various CSIT types
Creators: name: Dai, Mingbo
Publisher: name: Imperial College London
Year: 2016

description: In multiuser multi-antenna wireless systems, the transmission and beamforming strategies that achieve the sum rate capacity depend critically on the acquisition of perfect Channel State Information at the Transmitter (CSIT). Accordingly, a high-rate low-latency feedback link between the receiver and the transmitter is required to keep the latter accurately and instantaneously informed about the CSI. In realistic wireless systems, however, only imperfect CSIT is achievable due to pilot contamination, estimation error, limited feedback and delay, etc. As an intermediate solution, this thesis investigates novel transmission strategies suitable for various imperfect CSIT scenarios and the associated beamforming techniques to optimise the rate performance. First, we consider a two-user Multiple-Input-Single-Output (MISO) Broadcast Channel (BC) under statistical and delayed CSIT. We mainly focus on linear beamforming and power allocation designs for ergodic sum rate maximisation. The proposed designs enable higher sum rate than the conventional designs. Interestingly, we propose a novel transmission framework which makes better use of statistical and delayed CSIT and smoothly bridges between statistical CSIT-based strategies and delayed CSIT-based strategies. Second, we consider a multiuser massive MIMO system under partial and statistical CSIT. In order to tackle multiuser interference incurred by partial CSIT, a Rate-Splitting (RS) transmission strategy has been proposed recently. We generalise the idea of RS into the large-scale array. By further exploiting statistical CSIT, we propose a novel framework Hierarchical-Rate-Splitting that is particularly suited to massive MIMO systems. Third, we consider a multiuser Millimetre Wave (mmWave) system with hybrid analog/digital precoding under statistical and quantised CSIT. We leverage statistical CSIT to design digital precoder for interference mitigation while all feedback overhead is reserved for precise analog beamforming. For very limited feedback and/or very sparse channels, the proposed precoding scheme yields higher sum rate than the conventional precoding schemes under a fixed total feedback constraint. Moreover, a RS transmission strategy is introduced to further tackle the multiuser interference, enabling remarkable saving in feedback overhead compared with conventional transmission strategies. Finally, we investigate the downlink hybrid precoding for physical layer multicasting with a limited number of RF chains. We propose a low complexity algorithm to compute the analog precoder that achieves near-optimal max-min performance. Moreover, we derive a simple condition under which the hybrid precoding driven by a limited number of RF chains incurs no loss of optimality with respect to the fully digital precoding case.
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00321
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00321, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
On the Relationship Between Short-Time Objective Intelligibility and Short-Time Spectral-Amplitude Mean-Square Error for Speech Enhancement
Creators: name: Kolbæk, Morten
name: Tan, Zheng-Hua
name: Jensen, Jesper
Publisher: name: arXiv
Year: 2018
Subjects: subject: Sound (cs.SD)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The majority of deep neural network (DNN) based speech enhancement algorithms rely on the mean-square error (MSE) criterion of short-time spectral amplitudes (STSA), which has no apparent link to human perception, e.g. speech intelligibility. Short-Time Objective Intelligibility (STOI), a popular state-of-the-art speech intelligibility estimator, on the other hand, relies on linear correlation of speech temporal envelopes. This raises the question if a DNN training criterion based on envelope linear correlation (ELC) can lead to improved speech intelligibility performance of DNN based speech enhancement algorithms compared to algorithms based on the STSA-MSE criterion. In this paper we derive that, under certain general conditions, the STSA-MSE and ELC criteria are practically equivalent, and we provide empirical data to support our theoretical results. Furthermore, our experimental findings suggest that the standard STSA minimum-MSE estimator is near optimal, if the objective is to enhance noisy speech in a manner which is optimal with respect to the STOI speech intelligibility estimator.
Self-Consistent Evolution of Ring Galaxies
Creators: name: Mazzei, Paola
name: Anna
name: Curir
name: Bonoli, Carlotta
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Ring galaxies are commonly known as objects where a burst of star formation was triggered by a close encounter with an intruder, maybe a satellite galaxy. BVRI CCD observations of five ring galaxies have been performed. Here we present the results of a self-consistent approach to reproduce their observed morphology and spectral energy distribution using updated $N$--body simulations and evolutionary population synthesis models extending from UV to far--IR wavelengths. Some suggestions about the evolutionary properties of these starburst galaxies are then derived.
description: MNRAS accepted; latex file, 20 pages, 3 tables and 11 figures available upon request
A single mutation in the cis-acting replication element identified within the EV-A71 2C-coding region causes defects in virus production in cell culture
Creators: name: Xi, Juemin
name: Ma, Chunxia
name: Wei, Zhizhong
name: Yin, Bin
name: Zhao, Siwen
name: Quan, Wenqi
name: Yang, Jing
name: Yuan, Jiangang
name: Qiang, Boqin
name: Ye, Fei
name: Peng, Xiaozhong
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Enterovirus A71 (EV-A71) can cause hand, foot and mouth disease with neurological and systemic complications, most frequently affecting children and infants. We describe a cis-acting replication element (cre) with a conserved stem-loop structure within the EV-A71 2C-coding region. By site-directed mutagenesis and reverse genetics using the EV-A71 full-length genome and the EV-A71 replicon containing the firefly luciferase reporter gene in place of the P1 region, the stem-loop structure and the AAACA in the loop of the cre were confirmed to be required for the EV-A71 replication phenotype. EV-A71 genomes containing a mutation at the first or third A residue of AAACA could not be recovered. Insertion of a wild-type cre from EV-A71 or poliovirus in the 5’UTR led to successful recovery of the replication of nonviable mutants. Furthermore, the cre mutants showed lower binding capacity with the host cellular factor IGF2BP2, knockdown of which resulted in a significant decrease in EV-A71 production. All the available evidence shows the location independence but functional importance of the interaction of the cre with the cellular host for efficient production of EV-A71, contributing to the growing body of knowledge regarding picornavirus cres.
Augmented Reality in Education
Creators: name: Kumar, Amit
Publisher: name: figshare
Year: 2020
Subjects: subject: 80602 Computer-Human Interaction
subject: FOS: Psychology

description: Evolution of technology is now compelling changes in the present education system through augmented reality which provides new opportunities for improvement in the quality of teaching and learning. This paper reviews several literatures for the use of augmented reality in education.
Additional file 1 of sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression
Creators: name: He, Yuan
name: Chhetri, Surya B.
name: Arvanitis, Marios
name: Srinivasan, Kaushik
name: Aguet, François
name: Ardlie, Kristin G.
name: Barbeira, Alvaro N.
name: Bonazzola, Rodrigo
name: Im, Hae Kyung
name: Brown, Christopher D.
name: Battle, Alexis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 Supplementary figure. Figure S1 - S38.
Amygdala resting state functional connectivity in alcohol dependence
Creators: name: Orban, Csaba
Publisher: name: Imperial College London
Year: 2016

description: Alcohol dependence is a global societal problem, yet current avenues for its treatment are largely ineffective in slowing its chronic-relapsing trajectory. Animal studies of alcohol dependence have described neuroadaptations in the amygdala that may play a central role in mechanisms of relapse. In this thesis, spontaneous amygdala network function was examined in abstinent alcohol dependent patients (ADP) using functional magnetic resonance imaging within the framework of a multi-site neuroimaging platform: ICCAM. Participants underwent five scans that included baseline, as well as scans under placebo, acute antagonism of μ-opioid, Dopamine D3 (DRD3) and Neurokinin-1 (NK1) receptor systems previously implicated in mechanisms of addiction. At baseline, amygdala – substantia nigra/ventral tegmental area (SN/VTA) resting state functional connectivity (RSFC) was elevated in abstinent ADP, despite widespread grey-matter (GM) volumetric atrophy, in both amygdala and SN/VTA, compared with age-matched healthy controls (HC). The strength of amygdala – SN/VTA RSFC in ADP was primarily associated with years of cumulative alcohol exposure, but not with amygdala or SN/VTA GM volume, length of abstinence, smoking status, or head motion. Amygdala RSFC with other regions showed sensitivity to core clinical features of ADP at baseline. Amygdala – frontoparietal (FPN) RSFC was inversely associated with abstinence length, with ADP in the first two months of abstinence showing significantly reduced amygdala – FPN RSFC compared with HC. Voxelwise comparison of amygdala RSFC between each drug session and placebo, did not reveal differential effects of receptor blockade on ADP and HC. Across both groups, however, the three drugs exhibited both overlapping and differential effects on distinct brain networks. Notably, amygdala RSFC in the superior temporal gyrus showed increases under NK1-antagonism, and decreases under naltrexone compared with placebo. Finally, amygdala – SN/VTA was significantly elevated in ADP relative to HC across all four sessions, suggesting that it may represent a stable neurophysiological feature of alcohol dependence.
Additional file 1: of Urine cultures in a long-term care facility (LTCF): time for improvement
Creators: name: J. Haaijman
name: E. Stobberingh
name: L. Van Buul
name: C. Hertogh
name: H. Horninge
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Qstnr reasons for urine cultures. Questionaire about reasons for ordering urine cultures. (DOCX 15Â kb)
The fetal brain in co-twins treated for twin-twin transfusion syndrome
Creators: name: Taylor-Clarke, Marisa
Publisher: name: Imperial College London
Year: 2015

description: Introduction : Twin-twin transfusion syndrome (TTTS) affects 10% of monochorionic pregnancies and provides a unique opportunity to study the impact of early environmental discordance in genetically identical twins. TTTS can be successfully treated with laser therapy but poor long term neurodevelopmental outcome remains a significant problem. Aberrant antenatal brain development may contribute to some of these deficits. The main aim of this study was to investigate differences in fetal brain development in identical twins treated for twin-twin transfusion syndrome. Methods : Thirty-nine twin pairs that had been treated by laser for TTTS underwent fetal MRI (1.5T) from 21 to 32 weeks gestational age. Volumetric segmentation of the fetal body was performed on 2D images whilst volumetric analysis of the supratentorial brain was performed on 3D reconstructed datasets. Development of the cortical surface was evaluated using an objective cortical scoring system. The metabolic profile of the fetal brain was assessed using magnetic resonance spectroscopy. Neurodevelopmental outcome was assessed at 1 and 2 years of age in surviving children. Results : Ex-donor fetuses had significantly smaller brains than their ex-recipient co-twins and showed evidence of global brain sparing. Extracerebral fluid volumes were significantly smaller in ex-donors relative to ex-recipient fetuses. Corrected cerebellar and cortical grey matter volumes were similar within twin pairs whereas maturation of the parieto-occipital fissure, central sulcus and Sylvian fissure was delayed in ex-donors compared to ex-recipients. Lactate was detected in 43% of fetal brains. By two years of age 20.8% of children followed up had significant neurodevelopmental impairment. This correlated with cortical maturation discordance within twin pairs. Conclusions : Significant differences in brain development exist between co-twins following laser treatment for TTTS. Discordance between twin fetuses correlates with later neurodevelopmental delay. Despite treatment and the absence of overt brain injury, in utero blood flow and endocrine influences may create divergent developmental paths in identical twins.
$Fermi$-LAT detection of a transient $γ$-ray source in the direction of a distant blazar B3 1428+422 at $z =4.72$
Creators: name: Liao, Neng-Hui
name: Li, Shang
name: Fan, Yi-Zhong
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report the detection of a transient $γ$-ray source in the direction of B3 1428+422 ($z=4.72$) by analyzing the 110-month {\it Fermi}-LAT Pass 8 data. The new transient $γ-$ray source is far away from the Galactic plane and has a rather soft spectrum, in agreement with being a high redshift blazar. We suggest that the newly discovered transient is the $γ$-ray counterpart of B3 1428+422, which could be the {\it most distant} GeV source detected so far. The detection of a group of such distant $γ-$ray blazars will be helpful to reconstruct the evolution of the luminosity function and to study the extragalactic background light at such high redshifts.
description: 9 pages, 4 figures, ApJL in press
Additional file 2 of Morphological characteristics and transcriptome analysis at different anther development stages of the male sterile mutant MS7–2 in Wucai (Brassica campestris L.)
Creators: name: Wang, Jian
name: Yang, Yitao
name: Zhang, Lei
name: Wang, Shaoxing
name: Yuan, Lingyun
name: Chen, Guohu
name: Tang, Xiaoyan
name: Hou, Jinfeng
name: Zhu, Shidong
name: Wang, Chenggang
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Fig. S2. Heatmap analysis of carbohydrate metabolism-related genes.
Infrared Colors at the Stellar/Substellar Boundary
Creators: name: Leggett, S. K.
name: Allard, F.
name: Hauschildt, P. H.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present new infrared photometry for 61 halo and disk stars around the stellar/substellar boundary. These data are combined with available optical photometry and astrometric data to produce color--color and absolute magnitude--color diagrams. The disk and halo sequences are compared to the predictions of the latest model atmospheres and structural models. We find good agreement between observation and theory except for known problems in the V and H passbands probably due to incomplete molecular data for TiO, metal hydrides and H$_2$O. The metal--poor M subdwarfs are well matched by the models as oxide opacity sources are less important in this case. The known extreme M subdwarfs have metallicities about one--hundredth solar, and the coolest subdwarfs have T$_{eff}\sim 3000$ K with masses $\sim $0.09M/M$_{\odot}$. The grainless models are not able to reproduce the flux distributions of disk objects with T$_{eff}
description: ApJ, in press. 18 pages. Also available at ftp://ftp.jach.hawaii.edu/pub/ukirt/skl/dM_preprint/
Development of precise chemical biology tools for imaging the oxytocin receptor within the central nervous system
Creators: name: Beard, Rhiannon
Publisher: name: Imperial College London
Year: 2016

description: The oxytocin system is linked with numerous neurological disorders but suffers from a lack of available tools to elucidate its role. To overcome these limitations, this thesis describes the manufacture of a positron emission tomography (PET) probe for the OT receptor using optimised Al18F chemistry. The tracer is validated through in vitro binding assays that demonstrate its avidity, selectivity and specificity. However, in spite of its favourable profile, in vivo biodistribution and nanoPET scans show limited brain uptake. As such, the utility of the tracer for brain imaging will not be realised unless the highly discriminative aspects of the blood-­brain barrier are overcome. Consequently, the secondary aim of this thesis focuses on novel approaches for improving macromolecular delivery to the brain. To achieve this feat, two pathways are typically exploited: (i) Absorptive-­ (AMT) or (ii) Receptor mediated transcytosis (RMT). While numerous ligands for these routes exist, the underlying molecular factors governing sorting at the blood-­brain barrier are largely unknown and uptake remains modest. To uncover the optimal features for uptake and trafficking at the blood-­brain barrier this thesis reports the initial screening campaign of novel, chemically defined vehicles for precise presentation. A highly convergent synthesis route allowed rapid access of a diverse library, elaborated with defined arrays of targeting motifs, which retained their secondary structure following construction. Cross examination of the library’s performance in endocytosis and transcytosis assays showed a synergic effect of merging AMT and RMT motifs on a single platform, whereby the ligand, valency and position of the targeting modalities influenced uptake and sorting. Overall this thesis serves to guide the design and approach for selecting optimal brain delivery vehicles. The utility of these can be readily validated in vivo through attachment of the OT receptor tracer as molecular cargo.
Additional file 11: of Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma
Creators: name: Cheng-Lung Hsu
name: Kar-Wai Lui
name: Lang-Ming Chi
name: Yung-Chia Kuo
name: Yin-Kai Chao
name: Yeh, Chun-Nan
name: Lee, Li-Yu
name: Yenlin Huang
name: Tung-Liang Lin
name: Mei-Yuan Huang
name: Lai, Yi-Ru
name: Yeh, Yuan-Ming
name: Hsien-Chi Fan
name: Lin, An-Chi
name: Yen-Jung Lu
name: Chia-Hsun Hsieh
name: Chang, Kai-Ping
name: Ngan-Ming Tsang
name: Hung-Ming Wang
name: Chang, Alex
name: Yu-Sun Chang
name: Hsin-Pai Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: Figure S6. Differentially expressed genes of PDX-Bone exposed to five different drugs. Volcano plots (left panel) generated by analysis of differential gene expression based on RNA sequencing data on PDX-Bone with five drug treatments: (A) GEM, (B) GSK126, (C) DEC, (D) PAL, and (E) GEM + PAL. The x-axis represents the log2 base fold change of PDX-B treated with different drugs and y-axis represents the p-value (â log10) for differential gene expression. Other genes that passed quality control are presented as gray dots. Up-regulated (red dots) and downregulated (green dots) genes are indicated. Enriched KEGG cellular pathways (right panel) are presented as circles according to scores from enrichment p-value (â log10) (y-axis) and topology analysis (pathway enrichment factor, x-axis). The circle color scale (red to green) indicates the significance of the pathway. The size of the circle represents the number of genes involved in the pathway. (F) The KEGG cell cycle pathway. Green boxes represent downregulated genes in the cell cycle pathway of PDX-B treated with PAL. (PDF 961 kb)
The Cluster Distribution as a Test for Dark Matter Models. II: The Dipole Structure
Creators: name: Brunozzi, P. Tini
name: Borgani, S.
name: Plionis, M.
name: Moscardini, L.
name: Coles, P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the dipole for a redshift sample of Abell/ACO clusters. To elucidate the constraints it places on dark matter models, we use numerical simulations based on the Zel'dovich approximation. We run 20 realizations of each of six different dark matter models: four of these have a density parameter $Ω_0=1$, while the other two have $Ω_0=0.2$, one with and one without a cosmological constant term. For the Abell/ACO sample, we evaluate the parameter $β=Ω_0^{0.6}/b_{ cl}$, which reaches its asymptotic value at $R=160 Mpc/h$. We find $β=0.15\pm 0.04$ and $0.25\pm 0.06$ in LG and CMB frames respectively. After identifying in the simulations LG-like observers, we construct mock cluster samples. We find that an alignment between the cluster dipole and observer velocity, such as that observed (about 20 degrees) should not be expected necessarily in the simulations. This, together with the large observer-to-observer variance estimates of $β$, makes it difficult to place any firm constraints on cosmological models. Our results demonstrate that the large amplitude and convergence depth of the cluster dipole cannot be taken as strong evidence either for or against a low--density Universe.
description: 15 pages + 7 figures uuencoded gzipped tarred Postscript file. Accepted for publication in MNRAS
Spectropolarimetry of the nova-like variable V1315 Aql
Creators: name: Dhillon, V. S.
name: Rutten, R. G. M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present spectropolarimetric observations of the eclipsing nova-like variable V1315 Aql, obtained with the aim of determining whether the single-peaked uneclipsed lines observed in this and related nova-likes are the result of disc emission scattered into the line of sight by the wind. The data show linear polarization with a mean value of 0.11+-0.02%. There are no significant differences between the continuum and line polarizations and no significant variations with wavelength or binary phase. We argue that the measured polarization may be attributed to scattering in the interstellar medium and hence conclude that there is no evidence of polarization intrinsic to V1315 Aql. We discuss alternative models which promise to resolve the controversy surrounding these objects.
description: uuencoded compressed postscript. The Figure is available at http://www.ast.cam.ac.uk/preprint/PrePrint.html
Linear Seesaw for Dirac Neutrinos with $A_4$ Flavour Symmetry
Creators: name: Borah, Debasish
name: Karmakar, Biswajit
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a linear seesaw model to realise light Dirac neutrinos within the framework of $A_4$ discrete flavour symmetry. The additional fields and their transformations under the flavour symmetries are chosen in such a way that naturally predicts the hierarchies of different elements of the seesaw mass matrix and also keeps the unwanted terms away. For generic choices of flavon alignments, the model predicts normal hierarchical light neutrino masses with the atmospheric mixing angle in the lower octant. Apart from predicting interesting correlations between different neutrino parameters as well as between neutrino and model parameters, the model also predicts the leptonic Dirac CP phase to lie in a specific range $-π/2\lesssim δ\lesssim -π/5$ and $π/5\lesssim δ\lesssim π/2$ that includes the currently preferred maximal value. The predictions for the absolute neutrino masses in one specific version of the model can also saturate the cosmological upper bound on sum of absolute neutrino masses.
description: 23 pages, 8 figures, matches the version accepted in Phys. Lett. B
Simia sylvanus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Atelidae
Simia
Simia sylvanus

description: Simia sylvanus [spec. nov.]
S. ecaudata, clunibus tuberoso-callosis. Syst. nat. 3.
Simia. Gesn. quadr. 847.
Simius cynocephalus alter. Alp. aegypt. 241. t. 16.
Cercopithecus. Jonst. quadr. t. 59. f. 5.
Habitat in Africa, Zeylona.
Frons ad superciliorum regioxem transverse gibba. Pellis ursina. Scrotum tamquam intra vulvam reconditum; vel penis intra Scroti foramen; autumno Testiuli intumescunt. Sedes Feminae rapi instar extuberans. Minatur minis, cachinno blanditur, caffrorum more salutat. Sorbilia manu haurit. Femina menstruat.
Anatome. E. N. C. d. 2. a. 7. obs. 40.
* * Cauda abbreviata: Papiones.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 25, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 5 of Morphological characteristics and transcriptome analysis at different anther development stages of the male sterile mutant MS7–2 in Wucai (Brassica campestris L.)
Creators: name: Wang, Jian
name: Yang, Yitao
name: Zhang, Lei
name: Wang, Shaoxing
name: Yuan, Lingyun
name: Chen, Guohu
name: Tang, Xiaoyan
name: Hou, Jinfeng
name: Zhu, Shidong
name: Wang, Chenggang
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Table S1. Identification of all DEGs associated with anther and pollen development in Wucai.
Self-consistent Gravitational Lens Reconstruction
Creators: name: Dye, S.
name: Taylor, A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a new method for directly determining accurate, self-consistent cluster lens mass and shear maps in the strong lensing regime from the magnification bias of background galaxies. The method relies upon pixellisation of the surface mass density distribution which allows us to write down a simple, solvable set of equations. We also show how pixellisation can be applied to methods of mass determination from measurements of shear and present a simplified method of application. The method is demonstrated with cluster models and applied to magnification data from the lensing cluster Abell 1689.
description: 5 pages, 4 figures. References added to introduction. Accepted by MNRAS
Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data
Creators: name: Huang, Hang
name: Xu, Haokai
name: Li, Ping
name: Ye, Xueting
name: Chen, Wei
name: Huang, Xixi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic analysis of public datasets from The Cancer Genome Atlas database (TCGA). The results showed that the expression levels of ZFC3H1 were notably lower than the corresponding non-cancerous tissues in prostate adenocarcinoma (PRAD), and patients in the high ZFC3H1-expression group showed poor survival. We hypothesized that the low expression of ZFC3H1 in tumor tissue might have be an inhibitory effect on the autoimmune system. We predicted the regulatory target and protein interaction partner network of ZFC3H1, and identified a PPI network composed of 26 node genes in PRAD. Furthermore, we found that the expression levels of MPHOSPH6 (encoding M-phase phosphoprotein 6) and MRPS31 (encoding mitochondrial ribosomal protein S31) were lower in PRAD tissues than in non-cancerous tissues, and the survival time of patients with high MPHOSPH6 and MRPS31 expression was poor. To further demonstrate the role of ZC3H1 in PRAD, we knocked-down the ZFC3H1 expression and found that the inhibition of ZFC3H1 significantly inhibited PRAD cell migration and invasion. Furthermore, ZFC3H1 siRNA treatment could reduce cell viability and increase the number of apoptotic cells in PRAD cells. Taken together, ZFC3H1 could represent a new marker for PRAD prognosis and provide a reference for the development of new therapies to treat PRAD.
The control of blood vessel formation and function through the Von Willebrand Factor – Angiopoietin 2 pathway:in vitro, in vivo and patient studies
Creators: name: Smith, Koval Elrado
Publisher: name: Imperial College London
Year: 2017

description: Von Willebrand Factor (VWF) is a large glycoprotein synthesised by endothelial cells (EC) and megakaryocytes. Defects in VWF cause the most common inherited bleeding disorder in humans, Von Willebrand disease (VWD). Some patients with VWD present with vascular malformations in the gastrointestinal (GI) tract (angiodysplasia), which can lead to severe intractable bleeding. Angiodysplasia may be linked to the ability of VWF to regulate blood vessel formation. VWF drives the formation of Weibel Palade Bodies (WPB) which store a key regulator of angiogenesis and permeability, Angiopoietin 2 (Ang-2). In this study, I investigate how VWF controls vascular formation and function through Ang-2. Inhibition of VWF expression in ECs caused enhanced synthesis and release of Ang-2. In addition, ECs isolated from a patient with a severe quantitative defect in VWF (type 3 VWD) showed enhanced synthesis and release of Ang-2, confirming that VWF regulates Ang-2 storage and synthesis in ECs. I investigate whether VWF regulates Ang-2 in vivo, and find that Ang-2 expression is increased in the hearts but not lungs of VWF-deficient mice, indicating a tissue specific regulation. I then investigate the pathway though which VWF may regulate Ang-2 expression. I show that VWF controls Ang-2 synthesis through a pathway involving Akt phosphorylation and the transcription factor FOXO1. I demonstrate a role for atorvastatin in pharmacological manipulation of this pathway, which may be relevant for patients with angiodysplasia and therapeutic manipulation of Ang-2 levels. Inhibition of Ang-2 was able to normalise the VWF-dependent increase in in vitro vascular sprouting. In vivo, increased expression of Ang-2 in the heart of VWF-deficient mice correlates with enhanced vascularisation. Furthermore, cardiac vessels from VWF-deficient mice showed enhanced permeability compared to controls assessed by perfusion of low (4.4 x 103) molecular weight dextran. The results of this thesis provides evidence for the role of VWF in controlling angiogenesis via an Ang-2 dependent pathway. Thus may suggest a novel molecular mechanism which may contribute to VWD associated vascular malformations.
Dark side of the Seesaw
Creators: name: Bhattacharya, Subhaditya
name: Varzielas, Ivo de Medeiros
name: Karmakar, Biswajit
name: King, Stephen F.
name: Sil, Arunansu
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In an attempt to unfold (if any) a possible connection between two apparently uncorrelated sectors, namely neutrino and dark matter, we consider the type-I seesaw and a fermion singlet dark matter to start with. Our construction suggests that there exists a scalar field mediator between these two sectors whose vacuum expectation value not only generates the mass of the dark matter, but also takes part in the neutrino mass generation. While the choice of $Z_4$ symmetry allows us to establish the framework, the vacuum expectation value of the mediator field breaks $Z_4$ to a remnant $Z_2$, that is responsible to keep dark matter stable. Therefore, the observed light neutrino masses and relic abundance constraint on the dark matter, allows us to predict the heavy seesaw scale as illustrated in this paper.The methodology to connect dark matter and neutrino sector, as introduced here, is a generic one and can be applied to other possible neutrino mass generation mechanism and different dark matter candidate(s).
description: 28 pages, 16 figures, matches the version accepted in JHEP
Pair annihilation radiation from relativistic jets in gamma-ray blazars
Creators: name: Boettcher, M.
name: Schlickeiser, R.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The contribution of the pair annihilation process in relativistic electron-positron jets to the gamma-ray emission of blazars is calculated. Under the same assumptions as for the calculation of the yield of inverse Compton scattered accretion disk radiation (Dermer and Schlickeiser 1993) we calculate the emerging pair annihilation radiation taking into account all spectral broadening effects due to the energy spectra of the annihilating particles and the bulk motion of the jet. It is shown that the time-integrated pair annihilation spectrum appears almost like the well-known gamma-ray spectrum from decaying $π^o$-mesons at rest, yielding a broad bumpy feature located between 50 and 100 MeV. We also demonstrate that for pair densities $> 10^9$ cm$^{-3}$ in the jet the annihilation radiation will dominate the inverse Compton radiation, and indeed may explain reported spectral bumps at MeV energies. The refined treatment of the inverse Compton radiation leads to spectral breaks of the inverse Compton emission in the MeV energy range with a change in spectral index $Δα$ larger than 0.5 as detected in PKS 0528+134 and 3C273.
title: Über eine multiparadigmatische Soziologie
Creators: name: Burzan, Nicole
Publisher: name: SSOAR -   GESIS Leibniz Institute for the Social Sciences
Year: 2019
Subjects: subject: 10201 General Sociology, Basic Research, General Concepts and History of Sociology, Sociological Theories

description: In der schriftlichen Fassung der Eröffnungsrede des Göttinger Soziologiekongresses 2018 wird diskutiert, inwiefern die Soziologie als multiparadigmatische Disziplin zu verstehen ist und welche Anknüpfungspunkte es für eine "streitbare" Verständigungsorientierung gibt.
description: The written version of the opening address at the Congress of Sociology in Göttingen 2018 discusses the extent to which sociology is to be understood as a multiparadigmatic discipline and which points of reference exist for a "disputatious" understanding.
description: Komplexe Dynamiken globaler und lokaler Entwicklungen: Verhandlungen des 39. Kongresses der Deutschen Gesellschaft für Soziologie in Göttingen 2018
Additional file 10: of Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma
Creators: name: Cheng-Lung Hsu
name: Kar-Wai Lui
name: Lang-Ming Chi
name: Yung-Chia Kuo
name: Yin-Kai Chao
name: Yeh, Chun-Nan
name: Lee, Li-Yu
name: Yenlin Huang
name: Tung-Liang Lin
name: Mei-Yuan Huang
name: Lai, Yi-Ru
name: Yeh, Yuan-Ming
name: Hsien-Chi Fan
name: Lin, An-Chi
name: Yen-Jung Lu
name: Chia-Hsun Hsieh
name: Chang, Kai-Ping
name: Ngan-Ming Tsang
name: Hung-Ming Wang
name: Chang, Alex
name: Yu-Sun Chang
name: Hsin-Pai Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology

description: Figure S5. Heatmap of RNA-seq data of PDX-B and with 5 drug treatments. RNA expression profiles of PDX-B (DMSO, control) and treated with 1. GEM, 2. GSK126, 3. DEC, 4. PAL, 5. GEM+PAL. The color scale (red, yellow and blue) indicates the expression level (log10 RPKM) from high to low. (PDF 375 kb)
Efimov effect in a $D$-dimensional Born-Oppenheimer approach
Creators: name: Rosa, D. S.
name: Frederico, T.
name: Krein, G.
name: Yamashita, M. T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Nuclear Theory (nucl-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study a three-body system, formed by two identical heavy bosons and a light particle, in the Born-Oppenheimer approximation for an arbitrary dimension $D$. We restrict $D$ to the interval $2\,