cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(3223) Frederick Gouldthorpe Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On Equilibrium States for Partially Hyperbolic Horseshoes
Creators: name: Rios, Isabel
name: Siqueira, Jaqueline
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We prove existence and uniqueness of equilibrium states for a family of partially hyperbolic systems, with respect to Holder continuous potentials with small variation. The family comes from the projection, on the center-unstable direction, of a family of partially hyperbolic horseshoes introduced in [Díaz,L., Horita,V., Rios, I., Sambarino, M., Destroying horseshoes via heterodimensional cycles: generating bifurcations inside homoclinic classes, Ergodic Theory and Dynamical Systems, 2009]. For the original three dimensional system, we consider potentials with small variation, constant on local stable manifolds, obtaining existence and uniqueness of equilibrium states.
description: 29 pages, 7 figures
(3224) Thomas Wilson Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dealing with large gaps in asteroseismic time series
Creators: name: Bedding, Timothy R.
name: Kjeldsen, Hans
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: With long data sets available for asteroseismology from space missions, it is sometimes necessary to deal with time series that have large gaps. This is becoming particularly relevant for TESS, which is revisiting many fields on the sky every two years. Because solar-like oscillators have finite mode lifetimes, it has become tempting to close large gaps by shifting time stamps. Using actual data from the Kepler Mission, we show that this results in artificial structures in the power spectrum that compromise the measurements of mode frequencies and linewidths.
description: published in RNAAS
Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.
Creators: name: Swick, A. G.
name: Jambou, R. C.
name: Blake, M. C.
name: Azizkhan, J. C.
name: Kahn, J. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Numerous genes contain TATAA-less promoters, and the control of transcriptional initiation in this important promoter class is not understood. We have determined that protein-DNA interactions at three of the four proximal GC box sequence elements in one such promoter, that of the hamster dihydrofolate reductase gene, control initiation and relative use of the major and minor start sites. Our results indicate that although the GC boxes are apparently equivalent with respect to factor binding, they are not equivalent with respect to function. At least two properly positioned GC boxes were required for initiation of transcription. Abolishment of DNA-protein interaction by site-specific mutation of the most proximal GC box (box I) resulted in a fivefold decrease in transcription from the major initiation site and a threefold increase in heterogeneous transcripts initiating from the vicinity of the minor start site in vitro and in vivo. Mutations that separately abolished interactions at GC boxes II and III while leaving GC box I intact affected the relative utilization of both the major and minor initiation sites as well as transcriptional efficiency of the promoter template in in vitro transcription and transient expression assays. Interaction at GC box IV when the three proximal boxes were in a wild-type configuration had no effect on transcription of the dihydrofolate reductase gene promoter. Thus, GC box interactions not only are required for efficient transcription but also regulate start site utilization in this TATAA-less promoter.
(3219) Herbert Wharfedale Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Periodically driven Rydberg chains with staggered detuning
Creators: name: Mukherjee, Bhaskar
name: Sen, Arnab
name: Sengupta, K.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the stroboscopic dynamics of a periodically driven finite Rydberg chain with staggered ($Δ$) and time-dependent uniform ($λ(t)$) detuning terms using exact diagonalization (ED). We show that at intermediate drive frequencies ($ω_D$), the presence of a finite $Δ$ results in violation of the eigenstate thermalization hypothesis (ETH) via clustering of Floquet eigenstates. Such clustering is lost at special commensurate drive frequencies for which $\hbar ω_d=n Δ$ ($n \in Z$) leading to restoration of ergodicity. The violation of ETH in these driven finite-sized chains is also evident from the dynamical freezing displayed by the density-density correlation function at specific $ω_D$. Such a correlator exhibits stable oscillations with perfect revivals when driven close to the freezing frequencies for initial all spin-down ($|0\rangle$) or Neel ($|{\mathbb Z}_2\rangle$, with up-spins on even sites) states. The amplitudes of these oscillations vanish at the freezing frequencies and reduces upon increasing $Δ$; their frequencies, however, remains pinned to $Δ/\hbar$ in the large $Δ$ limit. In contrast, for the $|{\bar {\mathbb Z}_2}\rangle$ (time-reversed partner of $|{\mathbb Z}_2\rangle$) initial state, we find complete absence of such oscillations leading to freezing for a range of $ω_D$; this range increases with $Δ$. We also study the properties of quantum many-body scars in the Floquet spectrum of the model as a function of $Δ$ and show the existence of novel mid-spectrum scars at large $Δ$. We supplement our numerical results with those from an analytic Floquet Hamiltonian computed using Floquet perturbation theory (FPT) and also provide a semi-analytic computation of the quantum scar states within a forward scattering approximation (FSA).
description: v1; 19 pages, 19 figs
Budget Deficit Financing in Tanzania: Implications for Price Stabilization
Creators: name: Mwamkonko, Mussa Ally
name: Mwamkonko, Mussa Ally
Publisher: name: Unknown
Year: 2022
Subjects: subject: Financial Economics
subject: budget deficit
subject: financing
subject: co-integration
subject: error correction model
subject: inflation
subject: Tanzania

description: The study investigates whether budget deficit financing modes have differential implications on general price level in Tanzania. The study employs the co-integration and error correction modeling approach to examine the short-term and long-term effects of budget deficit financing on inflation. The study finds that the effects of budget deficit on general price level depends significantly on its financing modes. The results reveal that while domestic financing is inflationary foreign financing is deflationary. The results further show that seigniorage revenue financed budget deficit has no significant effect on price level whereas grants financed budget deficit has significant inflationary outcome. Moreover, the study finds that budget deficit financed by drawing down excess foreign reserves would mitigate inflation. Thus, to combat budget deficit oriented inflationary pressure, the government has to opt for external borrowing as opposed to internal borrowing and foreign aids in the nature of grants. In addition, the central bank has to control money supply and foreign reserves in such a way the additional money supply does not exceed expansion of the economy and excess foreign reserves could be used to finance budget deficit.
Online Read Ebook Practical RF Design Manual by Doug DeMaw
Creators: name: Taylor
Publisher: name: Zenodo
Year: 2024

description: Practical RF Design Manual by Doug DeMaw

 

 

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Practical RF Design Manual

Doug DeMaw

Page: 246

Format: pdf, ePub, mobi, fb2

ISBN: 9781891237003

Publisher: M F J Enterprises, Incorporated

 

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Nonseparability and von Neumann's theorem for domains of unbounded operators
Creators: name: ter Elst, A. F. M.
name: Sauter, Manfred
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46C07 (Primary), 47A05, 03E10 (Secondary)

description: A classical theorem of von Neumann asserts that every unbounded self-adjoint operator $A$ in a separable Hilbert space $H$ is unitarily equivalent to an operator $B$ in $H$ such that $D(A)\cap D(B)=\{0\}$. Equivalently this can be formulated as a property for nonclosed operator ranges. We will show that von Neumann's theorem does not directly extend to the nonseparable case. In this paper we prove a characterisation of the property that an operator range $\mathcal{R}$ in a general Hilbert space $H$ admits a unitary operator $U$ such that $U\mathcal{R}\cap\mathcal{R}=\{0\}$. This allows us to study stability properties of operator ranges with the aforementioned property.
การตัดสินใจเลือกอาชีพและการศึกษาของนักเรียนกับกรอบยุทธศาสตร์การพัฒนาทรัพยากรมนุษย์ของประเทศไทยระยะ 20 ปี : กรณีศึกษาโรงเรียนคงทองวิทยา จ.นครปฐม
Creators: name: อรษา ตันติยะวงศ์ษา
Publisher: name: ภาควิชาวิจัยและจิตวิทยาการศึกษา คณะครุศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: กรอบยุทธศาสตร์การพัฒนาทรัพยากรมนุษย์ของประเทศไทยระยะ 20 ปี
ทักษะด้าน STEM
เจตคติ

description: วารสารวิธีวิทยาการวิจัย (Journal of Research Methodology: JRM), 36, 1, 31-46
การถ่ายทอดการเรียนรู้ของผู้เข้าร่วมโปรแกรมเสริมสร้างทุนจิตวิทยาด้านสุขภาพที่เกี่ยวข้องกับกลุ่มโรคไม่ติดต่อเรื้อรังสู่ครอบครัว : การวิเคราะห์ข้อมูลระดับบุคคลและระดับครอบครัว
Creators: name: วิธัญญา วัณโณ
Publisher: name: ภาควิชาวิจัยและจิตวิทยาการศึกษา คณะครุศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: ทุนจิตวิทยาด้านสุขภาพ
กลุ่มโรคไม่ติดต่อเรื้อรัง
โปรแกรมเสริมสร้าง
ตัวแปรระดับกลุ่ม
การรวมค่าข้อมูล

description: วารสารวิธีวิทยาการวิจัย (Journal of Research Methodology: JRM), 36, 1, 47-62
(3220) Rebecca Huckvale
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
[PDF] Drawing From Photos: Problem Solving and Interpretation when Figure Drawing by Patrick J. Jones, Steve Huston
Creators: name: Downey
Publisher: name: Zenodo
Year: 2024

description: Drawing From Photos: Problem Solving and Interpretation when Figure Drawing by Patrick J. Jones, Steve Huston

 

 

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Drawing From Photos: Problem Solving and Interpretation when Figure Drawing

Patrick J. Jones, Steve Huston

Page: 160

Format: pdf, ePub, mobi, fb2

ISBN: 9781912740178

Publisher: Korero Press

 

Ebook for manual testing download Drawing From Photos: Problem Solving and Interpretation when Figure Drawing 9781912740178 (English Edition) PDB

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Evaluating second-order phase transitions with Diagrammatic Monte Carlo: Néel Transition in the doped three-dimensional Hubbard model
Creators: name: Lenihan, Connor
name: Kim, Aaram J.
name: IV., Fedor Šimkovic
name: Kozik, Evgeny
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Diagrammatic Monte Carlo -- the technique for numerically exact summation of all Feynman diagrams to high orders -- offers a unique unbiased probe of continuous phase transitions. Being formulated directly in the thermodynamic limit, the diagrammatic series is bound to diverge and is not resummable at the transition due to the non-analyticity of physical observables. This enables the detection of the transition with controlled error bars from an analysis of the series coefficients alone, avoiding the challenge of evaluating physical observables near the transition. We demonstrate this technique by the example of the Néel transition in the $3d$ Hubbard model. At half-filling and higher temperatures, the method matches the accuracy of state-of-the-art finite-size techniques, but surpasses it at low temperatures and allows us to map the phase diagram in the doped regime, where finite-size techniques struggle from the fermion sign problem. At low temperatures and sufficient doping, the transition to an incommensurate spin density wave state is observed.
ปัญหาสุขภาพที่เป็นอุปสรรคต่อการเรียนรู้ของนักเรียนในโรงเรียนนำร่องจังหวัดเชียงราย : การวิจัยแบบผสมวิธี
Creators: name: กนิษฐ์ ศรีเคลือบ
Publisher: name: ภาควิชาวิจัยและจิตวิทยาการศึกษา คณะครุศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: ปัญหาสุขภาพ
อุปสรรคต่อการเรียนรู้
การวิจัยแบบผสมวิธี

description: วารสารวิธีวิทยาการวิจัย (Journal of Research Methodology: JRM), 36, 1, 63-87
Universal metasurfaces for complete linear control of coherent light transmission
Creators: name: Chang, Taeyong
name: Jung, Joonkyo
name: Nam, Sang-Hyeon
name: Kim, Hyeonhee
name: Kim, Jong Uk
name: Kim, Nayoung
name: Jeon, Suwan
name: Heo, Minsung
name: Shin, Jonghwa
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Recent advances in metasurfaces and optical nanostructures have enabled complex control of incident light with optically thin devices. However, it has thus far been unclear whether it is possible to achieve complete linear control of coherent light transmission, i.e., independent control of polarization, amplitude, and phase for both input polarization states, with just a single, thin nanostructure array. Here we prove that it is possible and propose a universal metasurface, a bilayer array of high-index elliptic cylinders, that possesses a complete degree of optical freedom with fully designable chirality and anisotropy. We mathematically show the completeness of achievable light control with corresponding Jones matrices, experimentally demonstrate new types of three-dimensional holographic schemes that were formerly impossible, and present a systematic way of realizing any input-state-sensitive vector linear optical device. Our results unlock previously inaccessible degrees of freedom in light transmission control.
description: Main text: 30 pages, 5 figures. Supplementary discussion: 12 pages, 4 figures
Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation
Creators: name: Chen, Ruby
name: Horner, Kathleen
name: Threadgill, David W.
name: Lee, Daekee
name: Panigone, Sara
name: Hsieh, Minnie
name: Conti, Marco
name: Theologis, Alekos
name: Lee, David C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: In the preovulatory ovarian follicle, mammalian oocytes are maintained in prophase meiotic arrest until the luteinizing hormone (LH) surge induces reentry into the first meiotic division. Dramatic changes in the somatic cells surrounding the oocytes and in the follicular wall are also induced by LH and are necessary for ovulation. Here, we provide genetic evidence that LH-dependent transactivation of the epidermal growth factor receptor (EGFR) is indispensable for oocyte reentry into the meiotic cell cycle, for the synthesis of the extracellular matrix surrounding the oocyte that causes cumulus expansion, and for follicle rupture in vivo. Mice deficient in either amphiregulin or epiregulin, two EGFR ligands, display delayed or reduced oocyte maturation and cumulus expansion. In compound-mutant mice in which loss of one EGFR ligand is associated with decreased signaling from a hypomorphic allele of the EGFR, LH no longer signals oocyte meiotic resumption. Moreover, induction of genes involved in cumulus expansion and follicle rupture is compromised in these mice, resulting in impaired ovulation. Thus, these studies demonstrate that LH induction of epidermal growth factor-like growth factors and EGFR transactivation are essential for the regulation of a critical physiological process such as ovulation and provide new strategies for manipulation of fertility.
Analogue quantum simulation of the Hawking effect in a polariton superfluid
Creators: name: Jacquet, Maxime J.
name: Joly, Malo
name: Giacomelli, Luca
name: Claude, Ferdinand
name: Glorieux, Quentin
name: Bramati, Alberto
name: Carusotto, Iacopo
name: Giacobino, Elisabeth
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Quantum effects of fields on curved spacetimes may be studied in the laboratory thanks to quantum fluids. Here we use a polariton fluid to study the Hawking effect, the correlated emission from the quantum vacuum at the acoustic horizon. We show how out-of-equilibrium physics affects the dispersion relation, and hence the emission and propagation of correlated waves: the fluid properties on either side of the horizon are critical to observing the Hawking effect. We find that emission may be optimised by supporting the phase and density of the fluid upstream of the horizon in a regime of optical bistability. This opens new avenues for the observation of the Hawking effect in out-of-equilibrium systems as well as for the study of new phenomenology of fields on curved spacetimes.
description: 16 pages + appendix, 6 figures, comments are welcome. arXiv admin note: substantial text overlap with arXiv:2110.14452
MEKK1 Mediates the Ubiquitination and Degradation of c-Jun in Response to Osmotic Stress
Creators: name: Johnson, Gary L.
name: Wang, Ji
name: Xia, Yan
name: Xu, Shuichan
name: Hunter, Tony
name: Lu, Zhimin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: c-Jun, a major transcription factor in the activating protein 1 family of regulatory proteins, is activated by many physiologic and pathological stimuli. We show here that c-Jun was downregulated in response to osmotic stress via ubiquitination-dependent degradation by the PHD/RING finger domain of MEKK1, which exhibited E3 ubiquitin ligase activity toward c-Jun in vitro and in vivo. The reduced c-Jun protein level resulting from exogenous expression of wild-type MEKK1 and the opposite effect induced by expression of a MEKK1 PHD/RING finger domain mutant were consistent with a higher level of c-Jun protein in MEKK1−/− cells than in corresponding wild-type cells. The deficiency of MEKK1 blocked posttranslational downregulation of c-Jun in response to osmotic stress. Furthermore, apoptosis induced by osmotic stress was suppressed by overexpression of c-Jun, indicating that the downregulation of c-Jun promotes apoptosis.
การวิเคราะห์พัฒนาการของดัชนีการอ่านของไทย
Creators: name: วรรณี แกมเกตุ
Publisher: name: ภาควิชาวิจัยและจิตวิทยาการศึกษา คณะครุศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: การวิเคราะห์พัฒนาการ
ดัชนีการอ่านของไทย
พฤติกรรมการอ่าน
ความสามารถในการอ่าน
ผลลัพธ์จากการอ่าน

description: วารสารวิธีวิทยาการวิจัย (Journal of Research Methodology: JRM), 36, 1, 88-107
Innovative overcoatings for soft X-ray reflectivity enhancement
Creators: name: Cotroneo, Vincenzo
name: Rivolta, Giacomo
name: Bavdaz, Marcos
name: Bruni, Ricardo
name: Civitani, Marta Maria
name: Döhring, Thorsten
name: Ferreira, Ivo
name: Gibertini, Eugenio
name: Giglia, Angelo
name: Gollwitzer, Christian
name: Iovenitti, Simone
name: Krumney, Michael
name: Magagnin, Luca
name: Mahne, Nicola
name: Nannarone, Stefano
name: Pareschi, Giovanni
name: Romaine, Suzanne
name: Sethares, Leandra
name: Shortt, Brian
name: Skroblin, Dieter
name: Sironi, Giorgia
name: Spiga, Daniele
name: Tagliaferri, Gianpiero
name: Valsecchi, Giuseppe
Publisher: name: Zenodo
Year: 2022
Subjects: X-ray optics
light coatings
carbon coatings
soft X-rays
thin films
Athena
grazing incidence optics

description: “Dip-coatings” are a completely new technology for depositing a carbon-based overcoating on the reflecting surface of X-ray mirrors. This simple deposition process is controllable and repeatable, as well as scalable and inexpensive, and can be carried out without the requirement for specialistic equipment or trained personnel. We have considered the use of these coatings on different materials, in particular Ir monolayers and Ir/Cr bilayers, which can be convenient coatings for ATHENA mirrors. We measured the X-ray reflectivity of tens of samples in three different beamlines (one laboratory source and two synchrotron radiation facilities), covering a broad range of angular and energetic ranges. Results are in excellent agreement with the model and show that the technology has a good potential for application to X-ray optics and telescopes. More details can be found in the reference paper.
description: {"references": ["Cotroneo et al. (2022), \"Dopamine dip-liquid overcoatings for soft x-ray reflectivity enhancement,\" Proc. SPIE 12181, Space Telescopes and Instrumentation 2022: Ultraviolet to Gamma Ray, 1218117, https://doi.org/10.1117/12.2630212"]}
A compact concentration of large grains in the HD142527 protoplanetary dust trap
Creators: name: Casassus, Simon
name: Wright, Chris
name: Marino, Sebastian
name: Maddison, Sarah T.
name: Wootten, Al
name: Roman, Pablo
name: Perez, Sebastian
name: Pinilla, Paola
name: Wyatt, Mark
name: Moral, Victor
name: Menard, Francois
name: Christiaens, Valentin
name: Cieza, Lucas
name: van der Plas, Gerrit
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A pathway to the formation of planetesimals, and eventually giant planets, may occur in concentrations of dust grains trapped in pressure maxima. Dramatic crescent-shaped dust concentrations have been seen in recent radio images at sub-mm wavelengths. These disk asymmetries could represent the initial phases of planet formation in the dust trap scenario, provided that grain sizes are spatially segregated. A testable prediction of azimuthal dust trapping is that progressively larger grains should be more sharply confined and furthermore the trapped grains should follow a distribution that is markedly different from the gas. However, gas tracers such as CO and the infrared emission from small grains are both very optically thick where the submm continuum originates, so observations have been unable to test the trapping predictions or to identify compact concentrations of larger grains required for planet formation by core-accretion. Here we report multifrequency observations of HD142527, from 34GHz to 700GHz, that reveal a compact concentration of ~cm-sized grains, with a few Earth masses, embedded in a large-scale crescent of ~mm-sized particles. The emission peaks at wavelengths shorter than ~1mm are optically thick and trace the temperature structure resulting from shadows cast by the inner regions. Given this temperature structure, we infer that the largest dust grains are concentrated in the 34 GHz clump. We conclude that dust trapping is efficient for approximately cm-sized grains and leads to enhanced concentrations, while the smaller grains largely reflect the gas distribution.
description: Submitted to ApJ
Structural features discriminate androgen receptor N/C terminal and coactivator interactions
Creators: name: Wilson, Elizabeth M.
name: Hnat, Andrew T.
name: Askew, Emily B.
name: Minges, John T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Human androgen receptor (AR) transcriptional activity involves interdomain and coactivator interactions with the agonist-bound AR ligand binding domain (LBD). Structural determinants of the AR NH2- and carboxyl-terminal interaction between the AR NH2-terminal FXXLF motif and activation function 2 (AF2) in the LBD were shown previously by crystallography. In this report, we provide evidence for a region in AR LBD helix 12 outside the AF2 binding cleft that facilitates interactions with the FXXLF and LXXLL motifs. Mutagenesis of glutamine 902 to alanine in AR LBD helix 12 (Q902A) disrupted AR FXXLF motif binding to AF2, but enhanced coactivator LXXLL motif binding. Functional compensation for defective FXXLF motif binding by AR-Q902A was suggested by the slower dissociation rate of bound androgen. Functional importance of glutamine 902 was indicated by the charged residue germline mutation Q902R that caused partial androgen insensitivity, and a similar somatic mutation Q902K reported in prostate cancer, both of which increased the androgen dissociation rate and decreased AR transcriptional activity. High affinity equilibrium androgen binding was retained by alanine substitution mutations at Tyr-739 in AR LBD helix 5 or Lys-905 in helix 12 structurally adjacent to AF2, whereas transcriptional activity decreased and the androgen dissociation increased. Deleterious effects of these loss of function mutations were rescued by the helix stabilizing AR prostate cancer somatic mutation H874Y. Sequence NH2-terminal to the AR FXXLF motif contributed to the AR NH2- and carboxyl-terminal interaction based on greater AR-2-30 FXXLF motif peptide binding to the agonist-bound AR LBD than a shorter AR-20-30 FXXLF motif peptide. We conclude that helix 12 residues outside the AF2 binding cleft modulate AR transcriptional activity by providing flexibility to accommodate FXXLF or LXXLL motif binding.
Src kinase participates in LPS-induced activation of NADPH oxidase
Creators: name: Byrd, Christy L.
name: Hines, Ian N.
name: Menio, Jade
name: Check, Jennifer
name: Rippe, Richard A.
name: Wheeler, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The production of superoxide from NADPH oxidase by macrophages in response to endotoxin (LPS) is an important innate immune response, yet it is not clear how LPS signals the activation of NADPH oxidase. The hypothesis is that LPS-induced src kinase and PI3 kinase (PI3K) facilitates the activation of p47phox, the regulatory subunit of NADPH oxidase. In mouse macrophage RAW264.7 cells, inhibition of src tyrosine family kinases inhibited LPS-induced activation of NADPH oxidase, phosphorylation of p47phox, activation of PI3K and phosphorylation of the TLR4. Moreover, inhibition of LPS-induced increases in intracellular calcium blunted src kinase activation, PI3K association with TLR4, as well as PI3 kinase activation. These data suggest that both src kinase and PI3 kinase are involved in LPS-induced NADPH oxidase activation. Importantly, these data suggest that LPS-induced src kinase activation is critical for PI3 kinase activation as well as TLR4 phosphorylation and is dependent upon LPS-induced increase in intracellular calcium. These signaling events fill critical gaps in our understanding of LPS-induced free radical production as well as may potentially responsible for the mechanism of innate immune tolerance or desensitization caused by steroids or ethanol.
Theory of Nuclear Fission
Creators: name: Schunck, Nicolas
name: Regnier, David
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Atomic nuclei are quantum many-body systems of protons and neutrons held together by strong nuclear forces. Under the proper conditions, nuclei can break into two (sometimes three) fragments which will subsequently decay by emitting particles. This phenomenon is called nuclear fission. Since different fission events may produce different fragmentations, the end-products of all fissions that occurred in a small chemical sample of matter comprise hundreds of different isotopes, including $α$ particles, together with a large number of emitted neutrons, photons, electrons and antineutrinos. The extraordinary complexity of this process, which happens at length scales of the order of a femtometer, mostly takes less than a femtosecond but is not completely over until all the lingering $β$ decays have completed - which can take years - is a fascinating window into the physics of atomic nuclei. While fission may be more naturally known in the context of its technological applications, it also plays a pivotal role in the synthesis of heavy elements in astrophysical environments. In both cases, experimental measurements are not sufficient to provide complete data. Simulations are needed, yet at levels of accuracy and precision that pose formidable challenges to nuclear theory. The goal of this article is to provide a comprehensive overview of the theoretical methods employed in the description of nuclear fission.
description: 106 pages, 28 figures, 1 table, 513 references; submitted for publication in Progress in Nuclear and Particle Physics
Does Land Ownership Security Matter in Agricultural Productivity? Evidence from Panel Data in Tanzania
Creators: name: Selejio, Onesmo
name: Norman, Fatma
name: Selejio, Onesmo
name: Norman, Fatma
Publisher: name: Unknown
Year: 2022
Subjects: subject: Land Economics/Use
subject: Research Methods/ Statistical Methods
subject: agricultural productivity
subject: land ownership security
subject: panel data
subject: maize smallholder farmers
subject: Tanzania

description: This paper investigates the effect of land ownership security on agricultural productivity, specifically maize yield. It applies a Random Effect Model on a balanced panel sample size of 672 smallholder maize farmers derived from the last two waves of the Tanzania National Panel Survey (TNPS) data, which were collected in 2014/2015 (wave 4) and 2019/2020 (wave 5). The empirical results reveal that land ownership security is a significant factor in promoting agricultural productivity. Moreover, the results indicate that gender, farm size, education, and improved agricultural technologies significantly influence maize productivity. Thus, policies aimed to promote legal land ownership security are important in boosting smallholder farmers’ agricultural productivity and food security.
The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability: GonococcalpilQmutants with increased antibiotic resistance
Creators: name: Nicholas, Robert A.
name: Hu, Mei
name: Zhao, Shuqing
name: Seifert, H. Steven
name: Tobiason, Deborah M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The penC resistance gene was previously characterized in a FA19 penA mtrR penB gonococcal strain (PR100) as a spontaneous mutation that increased resistance to penicillin and tetracycline. We show here that antibiotic resistance mediated by penC is the result of a Glu-666 to Lys missense mutation in the pilQ gene that interferes with the formation of the SDS-resistant high-molecular-mass PilQ secretin complex, disrupts piliation, and decreases transformation frequency by 50-fold. Deletion of pilQ in PR100 confers the same level of antibiotic resistance as the penC mutation, but increased resistance was observed only in strains containing the mtrR and penB resistance determinants. Site-saturation mutagenesis of Glu-666 revealed that only acidic or amidated amino acids at this position preserved PilQ function. Consistent with early studies suggesting the importance of cysteine residues on stability of the PilQ multimer, mutation of either of the two cysteine residues in FA19 PilQ led to a similar phenotype as penC: increased antibiotic resistance, loss of piliation, intermediate levels of transformation competence, and absence of SDS-resistant PilQ oligomers. These data show that a functional secretin complex can enhance the entry of antibiotics into the cell and suggest that the PilQ oligomer forms a pore in the outer membrane through which antibiotics diffuse into the periplasm.
Scaling Quantum Approximate Optimization on Near-term Hardware
Creators: name: Lotshaw, Phillip C.
name: Nguyen, Thien
name: Santana, Anthony
name: McCaskey, Alexander
name: Herrman, Rebekah
name: Ostrowski, James
name: Siopsis, George
name: Humble, Travis S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The quantum approximate optimization algorithm (QAOA) is an approach for near-term quantum computers to potentially demonstrate computational advantage in solving combinatorial optimization problems. However, the viability of the QAOA depends on how its performance and resource requirements scale with problem size and complexity for realistic hardware implementations. Here, we quantify scaling of the expected resource requirements by synthesizing optimized circuits for hardware architectures with varying levels of connectivity. Assuming noisy gate operations, we estimate the number of measurements needed to sample the output of the idealized QAOA circuit with high probability. We show the number of measurements, and hence total time to solution, grows exponentially in problem size and problem graph degree as well as depth of the QAOA ansatz, gate infidelities, and inverse hardware graph degree. These problems may be alleviated by increasing hardware connectivity or by recently proposed modifications to the QAOA that achieve higher performance with fewer circuit layers.
description: 10 pages, 5 figures
DOWNLOADS The 100 Tactical Patterns You Must Know Workbook: Practical Exercises to Spot the Key Chess Moves by Frank Erwich
Creators: name: Maggio
Publisher: name: Zenodo
Year: 2024

description: The 100 Tactical Patterns You Must Know Workbook: Practical Exercises to Spot the Key Chess Moves by Frank Erwich

 

 

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The 100 Tactical Patterns You Must Know Workbook: Practical Exercises to Spot the Key Chess Moves

Frank Erwich

Page: 304

Format: pdf, ePub, mobi, fb2

ISBN: 9789083387741

Publisher: New in Chess

 

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Probabilistic Constraint Programming for Parameters Optimisation of Generative Models
Creators: name: Zanin, Massimiliano
name: Correia, Marco
name: Sousa, Pedro A. C.
name: Cruz, Jorge
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Complex networks theory has commonly been used for modelling and understanding the interactions taking place between the elements composing complex systems. More recently, the use of generative models has gained momentum, as they allow identifying which forces and mechanisms are responsible for the appearance of given structural properties. In spite of this interest, several problems remain open, one of the most important being the design of robust mechanisms for finding the optimal parameters of a generative model, given a set of real networks. In this contribution, we address this problem by means of Probabilistic Constraint Programming. By using as an example the reconstruction of networks representing brain dynamics, we show how this approach is superior to other solutions, in that it allows a better characterisation of the parameters space, while requiring a significantly lower computational cost.
description: 12 pages, 5 figures. Presented at 17th Portuguese Conference on Artificial Intelligence - EPIA 2015
Disulfide Bond Bridge Insertion Turns Hydrophobic Anticancer Prodrugs into Self-Assembled Nanomedicines
Creators: name: Haynes, Matthew T.
name: Liu, Dan
name: Zhao, Linxiang
name: Wang, Dun
name: Zhang, Hongjuan
name: Zhang, Rong
name: Ma, Yan
name: Lin, Guimei
name: Fu, Qiang
name: Wang, Yongjun
name: Fallon, John K.
name: Zhao, Qiang
name: Zheng, Qingchuan
name: Yang, Xinggang
name: He, Zhonggui
name: Liu, Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: It is commonly observed that hydrophobic molecules alone cannot self-assemble into stable nanoparticles, requiring amphiphilic or ionic materials to support nanoparticle stability and function in vivo. We report herein newly self-assembled nanomedicines through entirely different mechanisms. We present proof-of-concept methodology and results in support of our hypothesis that disulfide-induced nanomedicines (DSINMs) are promoted and stabilized by the insertion of a single disulfide bond into hydrophobic molecules, in order to balance the competition between intermolecular forces involved in the self-assembly of nanomedicines. This hypothesis has been explored through diverse synthetic compounds, which include four first-line chemotherapy drugs (paclitaxel, doxorubicin, fluorouracil, and gemcitabine), two small-molecule natural products and their derivatives, as well as a fluorescent probe. Such an unprecedented and highly reproducible system has the potential to serve as a synthetic platform for a wide array of safe and effective therapeutic and diagnostic nanomedicine strategies.
The effect of co-location on human communication networks
Creators: name: Carmody, Daniel
name: Mazzarello, Martina
name: Santi, Paolo
name: Harris, Trevor
name: Lehmann, Sune
name: Abbiasov, Timur
name: Dunbar, Robin
name: Ratti, Carlo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The ability to rewire ties in communication networks is vital for large-scale human cooperation and the spread of new ideas. We show that lack of researcher co-location during the COVID-19 lockdown caused the loss of more than 4,800 weak ties -- ties between distant parts of the social system that enable the flow of novel information -- over 18 months in the email network of a large North American university. Furthermore, we find that the re-introduction of partial co-location through a hybrid work mode led to a partial regeneration of weak ties. We quantify the effect of co-location in forming ties through a model based on physical proximity, which is able to reproduce all empirical observations. Results indicate that employees who are not co-located are less likely to form ties, weakening the spread of information in the workplace. Such findings could contribute to a better understanding of the spatio-temporal dynamics of human communication networks, and help organizations that are moving towards the implementation of hybrid work policies evaluate the minimum amount of in-person interaction necessary for a productive work environment.
description: 19 pages, ~2500 words, 6 main figures. Supplementary information included as appendix. v3/v4 cleaned supplementary info. First two authors are co-first
Development of a novel orthotopic non-small cell lung cancer model and therapeutic benefit of 2′-(2-bromohexadecanoyl)-docetaxel conjugate nanoparticles
Creators: name: Yuan, Hong
name: Benhabbour, S. Rahima
name: Peng, Lei
name: Mumper, Russell J.
name: Feng, Lan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The aims of these studies were to establish an orthotopic non-small-cell lung cancer (NSCLC) mouse model, and to investigate the therapeutic efficacy of lipid-based nanoparticles (NPs) containing 2′-(2-bromohexadecanoyl)-docetaxel (Br-C16-DX) in this new model. A novel orthotopic NSCLC model was established in nude mice through dorsal side injection of luciferase-expressing A549 cells. The model was characterized by survival study, histological staining, bioluminescence imaging and PET/CT imaging. The therapeutic efficacy of the Br-C16-DX NPs versus Taxotere® was investigated in this model. The results demonstrated that mouse survival time was significantly prolonged by weekly intravenous administration of the NPs or Taxotere. Furthermore, the NPs group had 35 days longer progression-free survival and 27 days longer median survival compared to the Taxotere group. It was concluded that the developed orthotopic NSCLC model represents a feasible, reproducible, and clinically-relevant experimental mouse model to test current and potential therapies including nanomedicines.