cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of suppressor of cytokine signaling 3 in colorectal cancer
Creators: name: Hamilton, Kathryn Elizabeth
Publisher: name: University of North Carolina at Chapel Hill
Year: 2010

description: Patients with inflammatory bowel diseases (IBD) have an increased lifetime risk of developing colorectal cancer (CRC). Suppressors of cytokine signaling (SOCS) are intracellular proteins that provide negative feedback on pro-inflammatory cytokine signaling. SOCS3 silencing in intestinal epithelial cells has previously been shown to promote tumorigenesis in the azoxymethane/dextran sodium sulfate (AOM/DSS) mouse model of inflammation-associated CRC. Mechanisms associated with this effect were increased activation of signal transducer and activator of transcription 3 (STAT3) and NF[kappa]B, and increased expression of TNF[alpha] receptor 2 (TNFR2). TNFR2 is increased in IBD and CRC, but how this receptor is regulated remains undefined. Studies in this dissertation tested the hypothesis that TNFR2 is induced by STAT3 and/or NF[kappa]B pathways, that SOCS3 limits TNFR2 expression, and that SOCS3 is a tumor suppressor in both sporadic and inflammation-associated cancer. Colon cancer cell lines were treated with IL-6 and TNF[alpha] in the presence of STAT3 or NF[kappa]B inhibitors. STAT3 inhibition dramatically decreased cytokine-induction of TNFR2, implicating STAT3 as a critical mediator of TNFR2 induction. SOCS3 limited cytokine-induction of TNFR2, as well as STAT3 binding to consensus sequences within the TNFR2 promoter. SOCS3 also limited TNFR2-mediated proliferation and anchorage-independent growth of colon cancer cells. Together these findings support the concept that SOCS3 exerts a tumor suppressor role in part by limiting the growth-promoting abilities of TNFR2. To test the whether low SOCS3 expression predicts risk of early stage CRC, biopsies of normal mucosa from colonoscopy patients with and without adenomas were assayed for SOCS3 mRNA. No significant difference in SOCS3 mRNA was observed in normal mucosa of patients with and without adenoma. Thus SOCS3 silencing in normal mucosa does not predict adenoma risk. To test whether SOCS3 normally limits tumorigenesis in sporadic CRC, mice with IEC-SOCS3 silencing were subjected to the AOM model of spontaneous, non-inflammatory CRC. Mice with SOCS3 silencing exhibited a 75% increase in colon tumor incidence. Collectively, these data indicate that SOCS3 normally modulates multiple pro-tumorigenic pathways that contribute to both inflammation-associated and sporadic CRC.
Explore the Dark Side of Proteome
Creators: name: Shao, Xinhao
Publisher: name: University of Illinois at Chicago
Year: 2023

description: Recent advancements in proteomics have improved protein identifications, but a significant portion of the proteome remains undetected, offering opportunities for exploring uncovered regions of proteome that may unveil valuable information such as post-translational modifications and protein isoforms. This study delves into the dark side of the proteome using various approaches. On the experimental side, a novel time-lapsed digestion method is developed to enhance sequence coverage and provide structural insights on extracellular matrix (ECM) proteome. The ECM plays a vital role in cellular processes and its dysregulation is associated with diseases such as fibrosis and cancer. While mass spectrometry-based proteomics has been instrumental in profiling ECM protein composition, limitations exist in capturing the dynamic range of protein abundance and obtaining structural information. The optimized time-lapsed proteomics method in our study surpasses traditional workflows in terms of sequence coverage, even outperforming traditional offline fractionation. On the informatics side, a proteomics knowledge database, MatrisomeDB, is developed to enhance sequence coverage and serves as a user-friendly web platform for the ECM research community. MatrisomeDB focuses solely on ECM proteomics, curating data from various ECM proteomics studies and providing direct quantitative comparison between projects. The database includes a comprehensive collection of ECM proteoforms and achieves near-complete sequence coverage of the predicted matrisome. Additionally, we utilize native limited proteolysis to validate protein structures predicted by AlphaFold. This is facilitated by a web application that visualizes sequence coverage on 3D protein structures. Protein structure determination has traditionally been challenging, but recent breakthroughs in deep learning-based protein prediction, such as AlphaFold, have shown promising results. However, the accuracy of predictions for proteins with unknown structures and domains still requires validation. The presented method using native limited proteolysis and visualization tool offers a means to validate predictions and potentially offer an opportunity to refine predicted protein structures. Overall, this study explores the darks side of proteome and improves proteome sequence coverage by developing and implementing a novel time lapsed digestion approach, and a searchable proteomics knowledge database. Last, as an application, we present a method to validate predicted AlphaFold protein structures with native limited proteolysis.
The effect of anisotropic exchange interactions and short-range phenomena on superfluidity in a homogeneous dipolar Fermi gas
Creators: name: Corro, I.
name: Martin, A. M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We develop a simple numerical method that allows us to calculate the Bardeen-Cooper-Schriefer (BCS) superfluid transition temperature (Tc) precisely for any interaction potential. We apply it to a polarised, ultracold Fermi gas with long-range, anisotropic, dipolar interactions and include the effects of anisotropic exchange interactions. We pay particular attention to the short-range behaviour of dipolar gasses and re-examine current renormalisation methods. In particular, we find that dimerisation of both atoms and molecules significantly hampers the formation of a superfluid. The end result is that at high density/interaction strengths, we find Tc is orders of magnitude lower than previous calculations.
description: 10 pages, 2 figures
The Global History of Reionisation
Creators: name: Greig, Bradley
name: Mesinger, Andrei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Using a Bayesian framework, we quantify what current observations imply about the history of the epoch of reionisation (EoR). We use a popular, three-parameter EoR model, flexible enough to accommodate a wide range of physically-plausible reionisation histories. We study the impact of various EoR observations: (i) the optical depth to the CMB measured by Planck 2016; (ii) the dark fraction in the Lyman $α$ and $β$ forests; (iii) the redshift evolution of galactic Ly$α$ emission (so-called "Ly$α$ fraction"); (iv) the clustering of Ly$α$ emitters; (v) the IGM damping wing imprint in the spectrum of QSO ULASJ1120+0641; (vi) and the patchy kinetic Sunyaev-Zel'dovich signal. Combined, (i) and (ii) already place interesting constraints on the reionisation history, with the epochs corresponding to an average neutral fraction of (75, 50, 25) per cent, constrained at 1$σ$ to $z= (9.21\substack{+1.22 -1.15}, 8.14\substack{+1.08 -1.00}, 7.26\substack{+1.13 -0.96})$. Folding-in more model-dependent EoR observations [(iii--vi)], strengthens these constraints by tens of per cent, at the cost of a decrease in the likelihood of the best-fit model, driven mostly by (iii). The tightest constraints come from (v). Unfortunately, no current observational set is sufficient to break degeneracies and constrain the astrophysical EoR parameters. However, model-dependent priors on the EoR parameters themselves can be used to set tight limits by excluding regions of parameter space with strong degeneracies. Motivated by recent observations of $z\sim7$ faint, lensed galaxies, we show how a conservative upper limit on the virial temperature of haloes which host reionising galaxies can constrain the escape fraction of ionising photons to $f_{\rm esc} = 0.14\substack{+0.26 -0.09}$
description: 15 pages, 12 figures, 1 table. Accepted to MNRAS, matches online version
Expanding Nuclear Physics Horizons with the Gamma Factory
Creators: name: Budker, Dmitry
name: Berengut, Julian C.
name: Flambaum, Victor V.
name: Gorchtein, Mikhail
name: Jin, Junlan
name: Karbstein, Felix
name: Krasny, Mieczyslaw Witold
name: Litvinov, Yuri A.
name: Pálffy, Adriana
name: Pascalutsa, Vladimir
name: Petrenko, Alexey
name: Surzhykov, Andrey
name: Thirolf, Peter G.
name: Vanderhaeghen, Marc
name: Weidenmüller, Hans A.
name: Zelevinsky, Vladimir
Publisher: name: arXiv
Year: 2021
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: Accelerator Physics (physics.acc-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The Gamma Factory (GF) is an ambitious proposal, currently explored within the CERN Physics Beyond Colliders program, for a source of photons with energies up to $\approx 400\,$MeV and photon fluxes (up to $\approx 10^{17}$ photons per second) exceeding those of the currently available gamma sources by orders of magnitude. The high-energy (secondary) photons are produced via resonant scattering of the primary laser photons by highly relativistic partially-stripped ions circulating in the accelerator. The secondary photons are emitted in a narrow cone and the energy of the beam can be monochromatized, eventually down to the $\approx1$ ppm level, via collimation, at the expense of the photon flux. This paper surveys the new opportunities that may be afforded by the GF in nuclear physics and related fields.
description: 69 pages, 13 tables, 33 figures
Maternal psychological control and youth HIV/AIDS risk behavior: a study of African American single mother families
Creators: name: Kincaid, Carlye Yates
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The proposed study examined the relation between maternal psychological control, youth psychosocial adjustment and youth HIV/AIDS risk behavior (e.g., sexual intercourse and alcohol use) in a community sample of 194 African American single mother-youth (11-16 year old) dyads. As predicted, higher levels of maternal psychological control were associated with increased psychosocial adjustment problems, as well as an increased likelihood that youth would report engaging in sexual intercourse and alcohol use. Furthermore, youth externalizing problems were found to mediate the relation between psychological control and HIV/AIDS risk behavior; accordingly, greater psychological control was associated with greater externalizing problems which, in turn, was associated with increased odds that youth would engage in alcohol use and sexual intercourse. Findings are discussed with regard to their implications for family-based HIV/AIDS risk behavior prevention programs aimed at African American youth from single mother homes.
Propagating speed of primordial gravitational waves and inflation
Creators: name: Cai, Yong
name: Wang, Yu-Tong
name: Piao, Yun-Song
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that if the propagating speed of gravitational waves (GWs) gradually diminishes during inflation, the power spectrum of primordial GWs will be strongly blue, while that of the primordial scalar perturbation may be unaffected. We also illustrate that such a scenario is actually a disformal dual to the superinflation, but it does not have the ghost instability. The blue tilt obtained is $0
description: 18 pages, 4 figures; published version in PRD; two appendixes were moved to the main body; references and comments added, presentation improved
Les jeux d'argent et de hasard : une pratique intégrée au monde urbain ? Étude de cas sur le VIIe arrondissement parisien
Creators: name: Brun, Nicolas
Publisher: name: Zenodo
Year: 2021
Subjects: Gambling
Paris mutuel urbain
Française des jeux
Paris 7th arrondissement -- France

description: [Français] L’industrie des jeux d’argent et de hasard (JAH) a connu une croissance importante durant les cinquante dernières années, avec un allégement progressif de la législation qui les limitait jusque-là, aussi bien en France que dans un grand nombre d’autres pays. On ne compte aujourd’hui plus qu’une poignée de d'Etats à travers le monde dans lesquels les jeux d’argent sont encore interdits (Redon & Lebeau, 2021). L’essor de l’industrie du jeu se mesure aussi à l’importance de son marché, celui-ci s’évaluant aux alentours des 420 milliards de dollars en 2014 pour la partie légale et des 1 000 milliards si l’on englobe l’offre illégale (Redon & Lebeau, 2020). Suffisant pour faire des jeux d’argent et de hasard un « nouvel enjeu social ? » (Järvinen-Tassopoulos, 2010). Nous verrons dans ce mémoire comment les jeux d'argent et de hasard ont su s'intégrer aux espaces et pratiques urbaines du VIIe arrondissement. [English] The gambling industry has grown significantly over the past fifty years, with a gradual relaxation of the legislation that limited them until then, both in France and in many other countries. Today there are only a handful of states around the world in which gambling is still banned (Redon & Lebeau, 2021). The growth of the gaming industry is also measured by the size of its market, which is estimated at around 420 billion dollars in 2014 for the legal part and 1000 billion if we include illegal offer (Redon & Lebeau, 2020). Enough to make gambling a "new social issue?" ”(Järvinen-Tassopoulos, 2010). We will see in this thesis how gambling have been integrated into the urban spaces and practices of the 7th arrondissement of Paris.
description: Mémoire de recherche de Master 1. [English Title] Gambling: a practice integrated into the urban world? Case study on the 7th arrondissement of Paris
Diagnostik pneumonischer Veränderungen in der Röntgenthoraxübersichtsaufnahme bei Patienten mit ARDS
Creators: name: Blumberg, Detlef
Publisher: name: Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
Year: 1999
Subjects: subject: ARDS
subject: Pneumonie
subject: Röntgenthorax
subject: Verschattungsqualitäten
subject: pneumonia
subject: radiographic chest view
subject: shadow quality
subject: 610 Medizin
subject: 33 Medizin
subject: YB 6700

description: Anlass dieser Studie war die Erfassung und Beurteilung radiologischer Genauigkeit in Thoraxübersichtsaufnahmen bei der Diagnostik von ARDS und Pneumonie. Dazu wurden von 84 Patienten (35 mit ARDS, 46 Patienten mit zusätzlicher Pneumonie) drei aufeinander folgende Aufnahmen befundet und hinsichtlich verschiedener radiomorphologischer Merkmale qualitativ, quantitativ und statistisch analysiert. Es konnte nachgewiesen werden, daß es für eine sichere Befundung von Röntgenthoraces keine statistisches Korrelat gibt (p > 0.6). Die Irrtumswahrscheinlichkeit für falsch positive und falsch negative Ergebnisse lag bei 78% und entsprach dabei den Angaben in der Literatur. Die Ergebnisse unterstreichen zudem die Feststellung, daß auch Serienaufnahmen nicht zur Verbesserung der diagnostischen Sicherheit führen, die Wertigkeit von Röntgenthoraxaufnahmen beim ARDS daher nur im Rahmen einer allgemeinen Verlaufsbeurteilung zu sehen ist.
description: In addition to general clinical factors involved in the course of ARDS, the aspect of pneumonia superimposed on ARDS, its incidence, the predisposing factors and the underlying sources of infection were to be analysed and the reasons for the different radiological interpretation of this disease reported in literature and practice were to be established. Three consecutive radiographic chest views of 84 patients (35 with ARDS, 49 with ARDS and primary or secondary pneumonia) which were optically and statistically comparable as regards their radiological features were reviewed and evaluated comparatively by discriminance analysis. The study showed that no statistical correlate exists (p > 0.6) for a reliable interpretation of adiographic chest views with regard to ARDS and/or ARDS with additional pneumonia. Furthermore, the results underline the fact that even a series of films obtained within a 24-hour interval cannot help to improve the diagnostic safety and that, consequently, radiographic chest views are of value only for a general assessment of the course of ARDS, whether with or without accompanying pneumonia.
Additional file 1 of Circulating NPTX2 methylation as a non-invasive biomarker for prognosis and monitoring of metastatic pancreatic cancer
Creators: name: García-Ortiz, María Victoria
name: Cano-Ramírez, Pablo
name: Toledano-Fonseca, Marta
name: Cano, María Teresa
name: Inga-Saavedra, Elizabeth
name: Rodríguez-Alonso, Rosa María
name: Guil-Luna, Silvia
name: Gómez-España, María Auxiliadora
name: Rodríguez-Ariza, Antonio
name: Aranda, Enrique
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Primers and probes for methylation analysis of different genes in cfDNA. Table S2. Comparison of NPTX2 methylation levels and Poisson’s error in patient samples at diagnosis and after initiation of treatment with and without pre-ddPCR amplification.
The Jacobi Stochastic Volatility Model
Creators: name: Ackerer, Damien
name: Filipović, Damir
name: Pulido, Sergio
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Finance (q-fin.MF)
subject: Computational Finance (q-fin.CP)
subject: FOS: Economics and business
subject: 91B25, 91B70, 91G20, 91G60

description: We introduce a novel stochastic volatility model where the squared volatility of the asset return follows a Jacobi process. It contains the Heston model as a limit case. We show that the joint density of any finite sequence of log returns admits a Gram-Charlier A expansion with closed-form coefficients. We derive closed-form series representations for option prices whose discounted payoffs are functions of the asset price trajectory at finitely many time points. This includes European call, put, and digital options, forward start options, and can be applied to discretely monitored Asian options. In a numerical analysis we show that option prices can be accurately and efficiently approximated by truncating their series representations.
description: 32 pages, 5 Figures, 1 Table
The Cauchy-Riemann equation with support conditions on domains with Levi-degenerate boundaries
Creators: name: Brinkschulte, Judith
Publisher: name: Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II
Year: 2002
Subjects: subject: Cauchy-Riemann Gleichung
subject: pseudokonvexes Gebiet
subject: Fortsetzbarkeit von CR Funktionen
subject: Levi-degenerierte Hyperflächen
subject: Cauchy-Riemann equation
subject: pseudoconvex domain
subject: extension of CR functions
subject: Levi-degenerate hypersurfaces
subject: 510 Mathematik
subject: 27 Mathematik
subject: SK 780

description: In einem ersten Teil betrachten wir ein relativ kompaktes Gebiet Omega einer n-dimensionalen Kähler-Mannigfaltigkeit, mit Lipschitz-Rand, welches eine gewisse "log delta"-Pseudokonvexität besitzt. Wir zeigen, dass die Cauchy-Riemann Gleichung mit exaktem Träger in Omega für alle Bigrade (p,q) mit 0< q< n-1 eine Lösung besitzt. Ausserdem ist das Bild des Cauchy-Riemann Operators auf glatten (p,n-1)-Formen mit exaktem Träger in Omega abgeschlossen. Wir geben Anwendungen für die Lösbarkeit der tangentialen Cauchy-Riemann Gleichungen für glatte Formen und Ströme auf Rändern von schwach pseudokonvexen Gebieten Steinscher Mannigfaltigkeiten und für die Lösbarkeit der tangentialen Cauchy-Riemann Gleichungen für Ströme auf Levi-flachen CR Mannigfaltigkeiten beliebiger Kodimension. In einem zweiten Teil untersuchen wir die Cauchy-Riemann Gleichung mit Randbedingung Null entlang einer Hyperfläche mit konstanter Signatur. Wir geben Anwendungen für die Lösbarkeit der tangentialen Cauchy-Riemann Gleichung für glatte Formen mit kompaktem Träger und für Ströme auf der Hyperfläche. Wir zeigen auch, dass das Hartogs-Phänomen in schwach 2-konvex-konkaven Hyperflächen mit konstanter Signatur Steinscher Mannigfaltigkeiten gilt.
description: In a first part, we consider a domain Omega with Lipschitz boundary, which is relatively compact in an n-dimensional Kaehler manifold and satisfies some "log delta-pseudoconvexity" condition. We show that the Cauchy-Riemann equation with exact support in Omega admits a solution in bidegrees (p,q), 1 < q < n. Moreover, the range of the Cauchy-Riemann operator acting on smooth (p,n-1)-forms with exact support in Omega is closed. Applications are given to the solvability of the tangential Cauchy-Riemann equations for smooth forms and currents for all intermediate bidegrees on boundaries of weakly pseudoconvex domains in Stein manifolds and to the solvability of the tangential Cauchy-Riemann equations for currents on Levi-flat CR manifolds of arbitrary codimension. In a second part, we study the Cauchy-Riemann equation with zero Cauchy data along a hypersurface with constant signature. Applications to the solvability of the tangential Cauchy-Riemann equations for smooth forms with compact support and currents on the hypersurface are given. We also prove that the Hartogs phenomenon holds in weakly 2-convex-concave hypersurfaces with constant signature of Stein manifolds.
Coding sheets for the analysis of media narratives on migration (Work Package 3) in the H2020 project BRIDGES
Creators: name: Maneri, Marcello
Publisher: name: Zenodo
Year: 2023
Subjects: Coding sheet Media Newspapers TV Narratives Migration

description: Coding sheets for the analysis of media narratives on migration (Work Package 3) in the H2020 project BRIDGES
description: Free usage with citation
My voice on cloth: story quilters of the South Carolina Lowcountry
Creators: name: Hester, Susan Scott
Publisher: name: University of North Carolina at Chapel Hill
Year: 2010

description: My Voice on Cloth explores the lives and artistry of a group of African-American women art quilters based in the Lowcountry region of South Carolina. The thesis describes how art quilters use textiles to tell stories that challenge social constructs and negotiate identity, transforming a traditional medium into a contemporary art form. My research analyzes story or pictorial quilts as ethnographic narratives that serve to re-tell history, to reflect individual experience, to project the artist's voice, and to shape the creator's identity. I argue that story quilts are platforms for invention, re-interpretation, and cultural negotiation. By expanding the boundaries of her art each quiltmaker claims freedom of expression and the power to transform a practical skill into creative energy capable of pushing the world in a new direction.
Approximating faces of marginal polytopes in discrete hierarchical models
Creators: name: Wang, Nanwei
name: Rauh, Johannes
name: Massam, Hélène
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: The existence of the maximum likelihood estimate in hierarchical loglinear models is crucial to the reliability of inference for this model. Determining whether the estimate exists is equivalent to finding whether the sufficient statistics vector $t$ belongs to the boundary of the marginal polytope of the model. The dimension of the smallest face $F_t$ containing $t$ determines the dimension of the reduced model which should be considered for correct inference. For higher-dimensional problems, it is not possible to compute $F_{t}$ exactly. Massam and Wang (2015) found an outer approximation to $F_t$ using a collection of sub-models of the original model. This paper refines the methodology to find an outer approximation and devises a new methodology to find an inner approximation. The inner approximation is given not in terms of a face of the marginal polytope, but in terms of a subset of the vertices of $F_t$. Knowing $F_t$ exactly indicates which cell probabilities have maximum likelihood estimates equal to $0$. When $F_t$ cannot be obtained exactly, we can use, first, the outer approximation $F_2$ to reduce the dimension of the problem and, then, the inner approximation $F_1$ to obtain correct estimates of cell probabilities corresponding to elements of $F_1$ and improve the estimates of the remaining probabilities corresponding to elements in $F_2\setminus F_1$. Using both real-world and simulated data, we illustrate our results, and show that our methodology scales to high dimensions.
description: 50 pages, 7 figures, 6 tables
A Higher Order Equilibrium Finite Element Method
Creators: name: Olesen, K.
name: Gervang, B.
name: Reddy, J. N.
name: Gerritsma, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper a mixed spectral element formulation is presented for planar, linear elasticity. The degrees of freedom for the stress are integrated traction components, i.e. surface force components. As a result the tractions between elements are continuous. The formulation is based on minimization of the complementary energy subject to the constraints that the stress field should satisfy equilibrium of forces and moments. The Lagrange multiplier which enforces equilibrium of forces is the displacement field and the Lagrange multiplier which enforces equilibrium of moments is the rotation. The formulation satisfies equilibrium of forces pointwise if the body forces are piecewise polynomial. Equilibrium of moments is weakly satisfied. Results of the method are given on orthogonal and curvilinear domains and an example with a point singularity is given.
description: 32 pages, 27 figures, Article accepted in International Journal for Numerical Methods in Engineering
Veränderungen von B-Zellantigenen unter Rituximab-Therapie
Creators: name: Jordanova, Maya
Publisher: name: Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
Year: 2004
Subjects: subject: B-CLL
subject: CD20
subject: FMC7
subject: indolente B-Zell-Lymphome
subject: Indolent B-cell lymphomas
subject: 610 Medizin
subject: 33 Medizin
subject: WF 9900
subject: YC 2500
subject: YV 4500

description: Das FMC7-Antigen, eine unbekannte B-Zell-Membranstruktur, dient als eines der immunphänotypischen Grundkriterien zur Diagnose der typischen B-CLL. Die unterschiedliche CD20-Expressionsintensität ist auch ein charakteristisches Merkmal bei der Subtypisierung der Lymphomentitäten. In der vorliegenden Arbeit wurde die Modulation des CD20- und des FMC7-Antigens während einer Therapie mit CD20-Antikörper (Rituximab) bei Patienten mit indolenten B-Zell-Lymphomen untersucht. Bei der durchflusszytometrischen Untersuchung quantitativer und qualitativer Charakteristika der monoklonalen B-Zell-Population bei CLL- (n=12) und Non-CLL-Patienten (n=10) unmittelbar nach der Antikörperinfusion und bis zur 8. Woche nach der Therapie wurden parallele Veränderungen von FMC7 und CD20 festgestellt. Die Anzahl und die Fluoreszenzintensitäten der für die beiden Antigene positiven Zellen korrelierten signifikant sowohl bei der malignen Zell-Population (Kurzzeitbeobachtung: n=89; r=0,9; p
description: The FMC7, although being an unknown structure of the B-cell membrane, represents one of the basic immunophenotypic criteria for the diagnosis of the typical B-CLL. A different CD20 expression is a characteristic sign for the sub-typing of lymphomas also. The underlying study investigated the qualitative and quantitative modulation of the CD20 and FMC7 antigens in patients with indolent B-cell lymphomas (CLL, n=12 and non-CLL, n=10) during the therapy with a CD20 antibody (rituximab). Concomitant changes of FMC7 and CD20 expression were found immediately after rituximab infusion and up to 8 weeks thereafter. A correlation was seen for the number of positive malignant cells and for the corresponding fluorescence intensity (short-time observation n=89; r=0.9; p
W-symmetry, topological vertex and affine Yangian
Creators: name: Procházka, Tomáš
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We discuss the representation theory of non-linear chiral algebra $\mathcal{W}_{1+\infty}$ of Gaberdiel and Gopakumar and its connection to Yangian of $\hat{\mathfrak{u}(1)}$ whose presentation was given by Tsymbaliuk. The characters of completely degenerate representations of $\mathcal{W}_{1+\infty}$ are for generic values of parameters given by the topological vertex. The Yangian picture provides an infinite number of commuting charges which can be explicitly diagonalized in $\mathcal{W}_{1+\infty}$ highest weight representations. Many properties that are difficult to study in $\mathcal{W}_{1+\infty}$ picture turn out to have a simple combinatorial interpretation.
description: JHEP version
Exploring sources of the association between sleep and risk-taking from late-childhood into adolescence
Creators: name: Bagley, Erika J.
Publisher: name: University of North Carolina at Chapel Hill
Year: 2011

description: This doctoral dissertation seeks to provide a deeper understanding of the association between sleep variables (sleep duration, variability and problems) and risk-taking behaviors (general delinquency, substance use and sexual risk-taking) from late childhood into adolescence. The study examines the change over time in sleep and risk-taking separately and the association between these variables over time. The influences of pubertal development and parental monitoring on the association between sleep and risk-taking are considered. Finally, executive functioning and impulse control are explored as possible mediators that may explain the association. Data for the study are drawn from the National Institutes of Child Health and Development Study of Early Child Care and Youth Development (NICHD SECCYD) sixth grade and 15 year data collections. As predicted, sleep variables demonstrated changes from sixth grade to 15 years that reflected worsening sleep with decreased sleep durations, increased variability, and increased sleep problems. Earlier pubertal development and greater parental monitoring were related to greater increases in sleep problems, but not other sleep variables. General risk-taking and substance use also increased over the period from sixth grade to 15 years. Greater parental monitoring was predictive of less increase in general risk-taking and substance use behaviors. Pubertal development was not predictive of change in risk-taking. All of the sleep variables were associated with general risk-taking, but not other risk-taking variables. Parental monitoring, but not pubertal development, moderated the effect of sleep on risk-taking. Executive functioning did not function as a mediator of the relationship between sleep and risk-taking. Impulse control did, however, play a mediating role, partially explaining the effect of sleep on risk-taking behaviors. Developmental systems theory frames the discussion of results, limitations and future directions.
Extreme depolarization for any spin
Creators: name: Denis, Jérôme
name: Martin, John
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The opportunity to build quantum technologies operating with elementary quantum systems with more than two levels is now increasingly being examined, not least because of the availability of such systems in the laboratory. It is therefore essential to understand how these single systems initially in highly non-classical states decohere on different time scales due to their coupling with the environment. In this work, we consider the depolarization, both isotropic and anisotropic, of a quantum spin of arbitrary spin quantum number $j$ and focus on the study of the most superdecoherent states. We approach this problem from the perspective of the collective dynamics of a system of $N=2j$ constituent spin-$1/2$, initially in a symmetric state, undergoing collective depolarization. This allows us to use the powerful language of quantum information theory to analyze the fading of quantum properties of spin states caused by depolarization. In this framework, we establish a precise link between superdecoherence and entanglement. We present extensive numerical results on the scaling of the entanglement survival time with the Hilbert space dimension for collective depolarization. We also highlight the specific role played by anticoherent spin states and show how their Markovian isotropic depolarization alone can lead to the generation of bound entangled states.
description: 28 pages, 11 figures, 3 tables
Workload Equity in Vehicle Routing Problems: A Survey and Analysis
Creators: name: Matl, Piotr
name: Hartl, Richard F.
name: Vidal, Thibaut
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: Over the past two decades, equity aspects have been considered in a growing number of models and methods for vehicle routing problems (VRPs). Equity concerns most often relate to fairly allocating workloads and to balancing the utilization of resources, and many practical applications have been reported in the literature. However, there has been only limited discussion about how workload equity should be modeled in VRPs, and various measures for optimizing such objectives have been proposed and implemented without a critical evaluation of their respective merits and consequences. This article addresses this gap with an analysis of classical and alternative equity functions for biobjective VRP models. In our survey, we review and categorize the existing literature on equitable VRPs. In the analysis, we identify a set of axiomatic properties that an ideal equity measure should satisfy, collect six common measures, and point out important connections between their properties and those of the resulting Pareto-optimal solutions. To gauge the extent of these implications, we also conduct a numerical study on small biobjective VRP instances solvable to optimality. Our study reveals two undesirable consequences when optimizing equity with nonmonotonic functions: Pareto-optimal solutions can consist of non-TSP-optimal tours, and even if all tours are TSP optimal, Pareto-optimal solutions can be workload inconsistent, i.e. composed of tours whose workloads are all equal to or longer than those of other Pareto-optimal solutions. We show that the extent of these phenomena should not be underestimated. The results of our biobjective analysis are valid also for weighted sum, constraint-based, or single-objective models. Based on this analysis, we conclude that monotonic equity functions are more appropriate for certain types of VRP models, and suggest promising avenues for further research.
description: Accepted Manuscript
Sonic Representations of Categorical Difference in Diegetic Video Game Music
Creators: name: Maenhout, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: In artistic works combining music and narration, composers have long used music to make statements about the works’ characters. Though much related scholarship exists concerning opera and film, little has been written about video game music and characters. This thesis argues that video game composers have used diegetic music – music making in which game characters participate – to draw attention to the categorical differences that distinguish characters of minority groups from the game’s majority. Drawing from scholarship on music and gender, critical race theory, and traditional Western music theory, I argue that the characters in three Fire Emblem games perform music inspired by real-world musical stereotypes associated with women and racially peripheral groups. Finally, I identify and fill, through a proposed syllabus, a lacuna in game music pedagogy so that undergraduate students might be taught to critically engage with these subject matters in and through video games.
Additional file 1 of Medications influencing the risk of fall-related injuries in older adults: case–control and case-crossover design studies
Creators: name: Jung, Yu-Seon
name: Suh, David
name: Kim, Eunyoung
name: Park, Hee-Deok
name: Suh, Dong-Churl
name: Jung, Sun-Young
Publisher: name: figshare
Year: 2023
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
classificationCode: 19999
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Supplementary Table 1. Subgroup analysis of the case-crossover design by CCI (0–1, 2–4, 5 or more). Supplementary Table 2. Sensitivity analysis of the case-crossover design with an additional washout period (control periods: 120–180 and 240–300 days prior to the index date).
Goldstone Boson Scattering with a Light Composite Scalar
Creators: name: Appelquist, T.
name: Brower, R. C.
name: Cushman, K. K.
name: Fleming, G. T.
name: Gasbarro, A.
name: Hasenfratz, A.
name: Ingoldby, J.
name: Jin, X. Y.
name: Kiskis, J.
name: Neil, E. T.
name: Osborn, J. C.
name: Rebbi, C.
name: Rinaldi, E.
name: Schaich, D.
name: Vranas, P.
name: Weinberg, E.
name: Witzel, O.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The appearance of a light composite $0^+$ scalar resonance in nearly conformal gauge-fermion theories motivates further study of the low energy structure of these theories. To this end, we present a nonperturbative lattice calculation of s-wave scattering of Goldstone bosons in the maximal-isospin channel in SU(3) gauge theory with $N_f=8$ light, degenerate flavors. The scattering phase shift is measured both for different values of the underlying fermion mass and for different values of the scattering momentum. We examine the effect of a light flavor-singlet scalar (reported in earlier studies) on Goldstone boson scattering, employing a dilaton effective field theory (EFT) at the tree level. The EFT gives a good description of the scattering data, insofar as the magnitude of deviations between EFT and lattice data are no larger than the expected size of next-to-leading order corrections in the EFT.
description: 13 pages, 6 figures, 4 tables. References and clarifying comments added. To match published version
Correspondence between Einstein-Yang-Mills-Lorentz systems and dynamical torsion models
Creators: name: Cembranos, Jose A. R.
name: Valcarcel, Jorge Gigante
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In the framework of Einstein-Yang-Mills theories, we study the gauge Lorentz group and establish a particular correspondence between this case and a certain class of theories with torsion within Riemann-Cartan space-times. This relation is specially useful in order to simplify the problem of finding exact solutions to the Einstein-Yang-Mills equations. The applicability of the method is divided into two approaches: one associated with the Lorentz group SO(1,n-1) of the space-time rotations and another one with its subgroup SO(n-2). Solutions for both cases are presented by the explicit use of this correspondence and, interestingly, for the last one by imposing on our ansatz the same kind of rotation and reflection symmetry properties as for a nonvanishing space-time torsion. Although these solutions were found in previous literature by a different approach, our method provides an alternative way to obtain them and it may be used in future research to find other exact solutions within this theory.
description: 10 pages, 0 figures, minor changes, references added. It matches the version published in Phys. Rev. D
Thomas Gregor SCHATTNER (Hg.) – Wolfram MARTINI, Mulva VII
Creators: name: Wolf, Markus
Publisher: name: Göttinger Forum für Altertumswissenschaft
Year: 2023

description: Rezension zu: Thomas Gregor Schattner (Hg.) – Wolfram Martini, Mulva VII. Die Ther­men und das Forum. Madrider Bei­träge Bd. 41, mit Beiträgen von C. Basas Fauré, M. Gutiérrez-Rodríguez, Ch. Hartl-Reiter, H. Ruipérez und D. Schäff­ler. Wiesbaden: Reichert 2021, 512 S., 411 Abb., 37 Taf., EUR 220,00. ISBN: 978-3-95490-508-9
description: Göttinger Forum für Altertumswissenschaft, Bd. 25 Nr. 1 (2022): Göttinger Forum für Altertumswissenschaft
Commemorating the Nanchang Uprising: How the Chinese Communist Party Legitimized Its Use of Force, 1933-1953
Creators: name: Bush, Sara M.
Publisher: name: University of North Carolina at Chapel Hill
Year: 2011

description: Drawing upon theoretical concepts from the field of memory studies, this thesis argues that Chinese Communist Party (CCP) leaders emphasized doctrinal priorities, mobilized troops, and legitimized their use of military force in part through annual commemoration of the August 1, 1927 Nanchang uprising, which they declared to be the founding event for the armies that became the PRC's armed forces. Tracing the evolution of the Nanchang uprising narrative between 1933, when CCP leaders first officially commemorated the event, and 1953, when Chinese involvement in the Korean War concluded, reveals new insight about how the Communist leaders used collective memory to recruit support for its continued use of military force, even as strategic priorities evolved. Official party documents and party-authored editorial articles directed at the public from 1933 to 1953 suggest that party members constructed a commemorative narrative about the 1927 uprising that they saw as legitimizing the party's military actions.
Additional file 1 of Neuraxial versus general anesthesia in elderly patients undergoing hip fracture surgery and the incidence of postoperative delirium: a systematic review and stratified meta-analysis
Creators: name: Cheung, Karis Yui-Lam
name: Yang, Timothy Xianyi
name: Chong, David Yew-Chuan
name: So, Eric Hang-Kwong
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
New hydrodynamic solutions for line-driven winds of hot massive stars using Lambert $W$-function
Creators: name: Gormaz-Matamala, Alex C.
name: Curé, Michel
name: Hillier, D. John
name: Najarro, Francisco
name: Kubátová, Brankica
name: Kubát, Jiří
Publisher: name: arXiv
Year: 2021
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Hot massive stars present strong stellar winds that are driven by absorption, scattering and re\-emission of photons by the ions of the atmosphere (\textit{line-driven winds}). A better comprehension of this phenomenon, and a more accurate calculation of hydrodynamics and radiative acceleration is required to reduce the number of free parameters in spectral fitting, to determine accurate wind parameters such as mass-loss rates and velocity profiles. We use the non-LTE model-atmosphere code CMFGEN to numerically solve the radiative transfer equation in the stellar atmosphere and to calculate the radiative acceleration $g_\text{rad}(r)$. Under the assumption that the radiative acceleration depends only on the radial coordinate, we solve analytically the equation of motion by means of the Lambert $W$-function. An iterative procedure between the solution of the radiative transfer and the equation of motion is executed in order to obtain a final self-consistent velocity field that is no longer based on any $β$-law. We apply the Lambert-procedure to three O supergiant stars ($ζ$-Puppis, HD~165763 and $α$-Cam) and discuss the Lambert-solutions for the velocity profiles. It is found that, even without recalculation of the mass-loss rate, the Lambert-procedure allows the calculation of consistent velocity profiles that reduce the number of free parameters when a spectral fitting using CMFGEN is performed. Synthetic spectra calculated from our Lambert-solutions show significant differences compared to the initial $β$-law CMFGEN models. The results indicate the importance of consistent velocity profile calculation in the CMFGEN code and its usage in a fitting procedure and interpretation of observed spectra.
description: Published in the Astrophysical Journal (ApJ), in 13 October 2021
Pollinator foraging flexibility and coexistence of competing plants
Creators: name: Revilla, Tomás A.
name: Křivan, Vlastimil
Publisher: name: arXiv
Year: 2016
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: We use the optimal foraging theory to study coexistence between two plant species and a generalist pollinator. We compare conditions for plant coexistence for non-adaptive vs. adaptive pollinators that adjust their foraging strategy to maximize fitness. When pollinators have fixed preferences, we show that plant coexistence typically requires both weak competition between plants for resources (e.g., space or nutrients) and pollinator preferences that are not too biased in favour of either plant. We also show how plant coexistence is promoted by indirect facilitation via the pollinator. When pollinators are adaptive foragers, pollinator's diet maximizes pollinator's fitness measured as the per capita population growth rate. Simulations show that this has two conflicting consequences for plant coexistence. On the one hand, when competition between pollinators is weak, adaptation favours pollinator specialization on the more profitable plant which increases asymmetries in plant competition and makes their coexistence less likely. On the other hand, when competition between pollinators is strong, adaptation promotes generalism, which facilitates plant coexistence. In addition, adaptive foraging allows pollinators to survive sudden loss of the preferred plant host, thus preventing further collapse of the entire community. Keywords: mutualism, competition, optimal foraging, evolutionarily stable strategy, coexistence, adaptation rate
description: 29 pages, 7 main figures, 2 appendix figures
Specters and Spooks: Developing A Hauntology of The Black Body
Creators: name: Powell, Kashif
Publisher: name: University of North Carolina at Chapel Hill Graduate School
Year: 2014
Subjects: Performing arts
Communication
African Americans--Study and teaching

description: This dissertation utilizes theories of embodiment and performance to develop a "hauntology of blackness," which investigates imaginative sites of death constructed through the historical, social, and performative facets of institutional slavery in the United States to theorize notions of blackness and the black body. I argue that the relationship between the black body and death have conjured a death-driven specter that manifest historically, performatively, visually, and phenomenally as blackness. The rise and continual return of this "specter of blackness" positions the black body in the United States as a body "haunted" by its own biological and phenotypical disposition. Placing the theory of Jacques Derrida and Frantz Fanon in conversation with scholars such as Avery Gordon, Saidiya Hartman, Toni Morrison, and others, I evoke the language of haunting to consider the profound effect the relationship between the black body and death has had on ontological, psychoanalytic, and phenomenological understandings of blackness within post-modernity.