cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation
Creators: name: Welch, C. L.
name: Sayers, S.
name: Kuo, C.-L.
name: Yvan-Charvet, L.
name: Li, R.
name: Tall, A. R.
name: Murphy, A. J.
name: Puig, O.
name: Krishnamurthy, J.
name: Liu, Y.
name: Davis, J. Z.
name: Sharpless, N. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Common genetic variants in a 58-kilobase region of chr 9p21, near the CDKN2A/CDKN2B tumor suppressor locus, are strongly associated with coronary artery disease. However, the underlying mechanism of action remains unknown.
Pointed Homotopy of Maps Between 2-Crossed Modules of Commutative Algebras
Creators: name: Akça, İ. İlker
name: Emir, Kadir
name: Martins, João Faria
Publisher: name: arXiv
Year: 2014
Subjects: subject: Category Theory (math.CT)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55U10 (principal), 18D05, 18D20, 55Q15 (secondary)

description: We address the homotopy theory of 2-crossed modules of commutative algebras, which are equivalent to simplicial commutative algebras with Moore complex of length two. In particular, we construct for maps of 2-crossed modules a homotopy relation, and prove that it yields an equivalence relation in very unrestricted cases (freeness up to order one of the domain 2-crossed module). This latter condition strictly includes the case when the domain is cofibrant. Furthermore, we prove that this notion of homotopy yields a groupoid with objects being the 2-crossed module maps between two fixed 2-crossed modules (with free up to order one domain), the morphisms being the homotopies between 2-crossed module maps.
description: 29 pages, Final version to appear in HHA
Effects of Government Policy on Agriculture: An Empirical Analysis
Creators: name: Lamm, R. McFall
name: Lamm, R. McFall
Publisher: name: Unknown
Year: 1980
Subjects: subject: Agricultural and Food Policy
subject: Research Methods/ Statistical Methods
subject: Agriculture policy
subject: farm programs
subject: price support
subject: land diversion
subject: food stamp program
subject: dairy price support program

description: Most empirical efforts to evaluate the effects of government policies on agriculture have considered policies applied to specific commodity sectors. The results have been the construction of a number of highly specialized sector models which ignore cross-sector policy effects. This paper presents the results of an attempt to construct an aggregate model of agriculture which considers jointly all major agricultural policies implemented over the last 3 decades. The results indicate that government intervention in agriculture generally reduced farm income and production below what it would have been; lead to lower food prices, benefitting consumers; and constrained capital for labor substitution. Government programs did lead to greater price stability, however, which was a basic objective of agricultural programs.
Focal Adhesion Kinase Regulates Smooth Muscle Cell Recruitment to the Developing Vasculature
Creators: name: Sayers, R. L.
name: Musunuri, S.
name: Taylor, J. M.
name: Mangiante, L. E.
name: Mack, C. P.
name: Sundberg-Smith, L. J.
name: Hakim, Z. S.
name: Maguire, C. T.
name: Majesky, M. W.
name: Cheng, Z.
name: Zhou, Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The investment of newly formed endothelial cell tubes with differentiated smooth muscle cells (SMC) is critical for appropriate vessel formation, but the underlying mechanisms remain unknown. We previously showed that depletion of focal adhesion kinase (FAK) in the nkx2.5 expression domain led to aberrant outflow tract (OFT) morphogenesis and strove herein to determine the cell types and mechanisms involved.
Additional file 1 of In search of an international multidimensional action plan for second victim support: a narrative review
Creators: name: Seys, Deborah
name: Panella, Massimiliano
name: Russotto, Sophia
name: Strametz, Reinhard
name: Joaquín Mira, José
name: Van Wilder, Astrid
name: Godderis, Lode
name: Vanhaecht, Kris
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1: Additional information
Formin Homology Domain-Containing Protein 1 Regulates Smooth Muscle Cell Phenotype
Creators: name: Mack, C. P.
name: Blaker, A. L.
name: Medlin, M. D.
name: Staus, D. P.
name: Taylor, J. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Our goal was to test whether formin homology protein 1 (FHOD1) plays a significant role in the regulation of SMC differentiation, and if so, whether Rho-kinase (ROCK)-dependent phosphorylation in the diaphanous auto-inhibitory domain is an important signaling mechanism that controls FHOD1 activity in SMC.
Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study
Creators: name: Tse, C.-K.
name: Olshan, A.F.
name: Troester, M.A.
name: Engel, L.S.
name: Parada, H., Jr
name: Sun, X.
Publisher: name: Elsevier Ltd
Year: 2019

description: Objectives: To examine plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) in association with survival among women with breast cancer who participated in a population-based case-control study. Methods: Participants included 456 white and 292 black women from the Carolina Breast Cancer Study Phase I who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had available DDE/DDT and lipid measurements from blood samples obtained on average 4.1 months after diagnosis. Using the National Death Index, we identified 392 deaths (210 from breast cancer) over a median follow-up of 20.6 years. We used Cox regression to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and breast cancer-specific 5-year mortality, and 20-year mortality conditional on 5-year survival, for lipid-standardized DDE and DDT levels. Associations stratified by race and estrogen receptor (ER) status were also examined. Results: The highest versus lowest DDE tertile and the highest vs non-detectable DDT quantile were associated with HRs of 1.95 (95% CI = 1.31–2.92) and 1.64 (95% CI = 1.10–2.44), respectively, for 20-year conditional all-cause mortality. DDE levels above versus below the median were associated with a HR of 1.69 (95% CI = 1.06–2.68) for 20-year conditional breast cancer-specific mortality among women overall, and HRs were 2.36 (95% CI = 1.03–5.42) among black women and 1.57 (95% CI = 0.86–2.89) among white women (PInteraction = 0.42), and 3.24 (95% CI = 1.38–7.58) among women with ER− tumors and 1.29 (95% CI = 0.73–2.28) among women with ER+ tumors (PInteraction = 0.03). Conclusion: Exposure to DDE/DDT may adversely impact overall and breast cancer-specific survival. DDE exposure may contribute to the racial disparities in breast cancer survival.
Additional file 1 of The confidante method to measure abortion: implementing a standardized comparative analysis approach across seven contexts
Creators: name: Owolabi, Onikepe O.
name: Giorgio, Margaret
name: Leong, Ellie
name: Sully, Elizabeth
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Appendix 1. Assumptions of the Confidante Method.
Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis
Creators: name: Stevens, J. W.
name: Griffin, J. H.
name: Erger, R. A.
name: Leo, L.
name: Fernandez, J. A.
name: Kim, H.-S.
name: Dwyre, D. M.
name: Lentz, S. R.
name: Wilson, K. M.
name: Maeda, N.
name: Raife, T. J.
name: Wilder, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We sought to develop a murine model to examine the antithrombotic and antiinflammatory functions of human thrombomodulin in vivo.
title: Why Bayesian inference?
Creators: name: Arhonditsis, George
Publisher: name: Friedrich-Schiller-Universität Jena
Year: 2018
Subjects: subject: Bayesian Inference
subject: Mechanistic Modelling
subject: Uncertainty Analysis
subject: Risk Assessment
subject: Adaptive Management Implementation
subject: 004
subject: 570
subject: 580
subject: 590
subject: 600
subject: 630

description: The scientific methodology of mathematical models and their credibility to form the basis of public policy decisions have been frequently challenged. The development of novel methods for rigorously assessing the uncertainty underlying model predictions is one of the priorities of the modelling community [1]. Striving for novel uncertainty analysis tools, I present the Bayesian calibration of process -based models as a methodological advancement that warrants consideration in ecosystem analysis and biogeochemical research [2]. This modelling framework combines the advantageous features of both process -based and statistical approaches; that is, mechanistic understanding that remains within the bounds of data- based parameter estimation. The incorporation of mechanism improves the confidence in predictions made for a variety of conditions, whereas the statistical methods provide an empirical basis for parameter value selection and all ow for realistic estimates of predictive uncertainty [3]. Other advantages of the Bayesian approach include the ability to sequentially update beliefs as new knowledge is available, the rigorous assessment of the expected consequences of different management actions, the optimization of the sampling design of monitoring programs, and the consistency with the scientific process of progressive learning and the policy practice of adaptive management. I illustrate some of the anticipated benefits from the Bayes ian calibration framework, well suited for stakeholders and policy makers when making environmental management decisions, using the Hamilton Harbour and the Bay of Quinte – two eutrophic systems in Ontario, Canada – as case studies [4]. REFERENCES: 1. Arhonditsis, G.B., Brett, M.T., 2004. Evaluation of the current state of mechanistic aquatic biogeochemical modelling. Mar. Ecol. Prog. Ser. 271, 13- 26. 2. Arhonditsis, G.B., Qian, S.S., Stow, C.A., Lamon, E.C., Reckhow, K.H., 2007. Eutrophication risk assessment using Bayesian calibration of process -based models: Application to a mesotrophic lake. Ecol Model. 208, 215-229 . 3. Arhonditsis G.B., Kim, D -K., Kelly, N. , Neumann, A. , Javed , A., 2017. Uncertainty Analysis by Bayesian Inference , in Recknagel , F. , Michener , W. , (Eds) , Ecological Informatics. 3 rd Edition Springer. , Cham, pp. 215-249. 4. Recknagel F., Arhonditsis, G.B. , Kim, D -K ., Nguyen H.H. , 2017. Strategic Forecasting in Ecology by Inferential and Process -based Models . in Recknagel , F., Michener , W. , (Eds), Ecological Informatics. 3 rd Edition Springer. , Cham, pp. 341-372.
Evolution of ferromagnetic and non-Fermi liquid state with doping:the case of Ru doped UCoGe
Creators: name: Vališka, Michal
name: Pospíšil, Jiří
name: Sechovský, Vladimír
name: Diviš, Martin
name: Abd-Elmeguid, Mohsen M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have investigated the impact of Ru substitution for Co on the behavior of the ferromagnetic superconductor UCoGe by performing x-ray diffraction, magnetization, specific heat and electrical resistivity measurements on polycrystalline samples of the $\mathrm{UCo}_{1-x}\mathrm{Ru}_{x}\mathrm{Ge}$ series ($0\geq x\leq0.9$). The initial Ru substitution up to $x\approx0.1$ leads to a simultaneous sharp increase of the Curie temperature and spontaneous magnetization up to maximum values of $T_{\mathrm{C}}=8.6 K$ and $M_{\mathrm{S}}=0.1 μ_{\mathrm{B}}$ per formula unit, respectively, whereas superconductivity vanishes already for $x\approx0.03$. Further increase of the Ru content beyond $x\approx0.1$ leads to a precipitous decrease of both, $T_{\mathrm{C}}$ and $M_{\mathrm{S}}$ towards a ferromagnetic quantum critical point (QCP) at $x_{\mathrm{cr}}=0.31$. Consequently the $T-x$ magnetic phase diagram consists of a well-developed ferromagnetic dome. We discuss the evolution of ferromagnetism with $x$ on the basis of band structure changes due to varying 5$f$-ligand hybridization. This scenario is supported by the results of electronic structure calculations and consideration of the simplified periodic Anderson model. The analysis of the temperature dependencies of the electrical resistivity and heat capacity at low temperatures of the samples in the vicinity of the QCP reveals a non-Fermi liquid behavior and assigns the ferromagnetic quantum phase transition to be most likely of a continuous Hertz-Millis type.
description: accepted for publication in PRB
Prediagnostic serum organochlorine insecticide concentrations and primary liver cancer: A case–control study nested within two prospective cohorts
Creators: name: O'Brien, T.R.
name: Grimsrud, T.K.
name: Van Den Eeden, S.K.
name: Rothman, N.
name: Satagopan, J.
name: Zhang, M.
name: Widell, A.
name: Engel, L.S.
name: Zabor, E.C.
Publisher: name: Wiley-Liss Inc.
Year: 2019

description: Although experimental evidence indicates that certain organochlorine insecticides are hepatocarcinogens, epidemiologic evidence for most of these chemicals is very limited. We estimated associations, using prospectively collected sera, between organochlorine insecticide concentrations and cancer registry-identified primary liver cancer in two cohorts, one from the United States and one from Norway. In nested case–control studies, we used sera collected in the 1960s-1980s from 136 cases and 408 matched controls from the Kaiser Permanente Northern California Multiphasic Health Checkup (MHC) cohort and 84 cases and 252 matched controls from the population-based Norwegian Janus cohort. We measured concentrations of nine organochlorine insecticides/metabolites and markers of hepatitis B and C in sera. Adjusted odds ratios (OR) and 95% confidence intervals (CI) for tertiles of lipid-corrected organochlorines were calculated for each cohort using conditional logistic regression. Among MHC participants with sera from the 1960s, there was a suggestive exposure-response trend for trans-nonachlor (second and third tertile of analyte ORs = 1.63 and 1.95, respectively; p-trend = 0.08) and a nonsignificantly elevated risk for the highest tertile of oxychlordane (OR = 1.87). Among Janus participants with sera from the 1970s, we observed an apparent trend for p,p’-DDT (second and third tertile ORs = 1.70 and 2.14, respectively; p-trend = 0.15). We observed little consistency in patterns of association between the cohorts. We found limited evidence that exposure to p,p’-DDT and chlordane-related oxychlordane and trans-nonachlor may be associated with increased risk of primary liver cancer. However, the modest strength of these associations and their lack of concordance between cohorts necessitate caution in their interpretation.
Molecular Mechanisms Affecting Fibrin Structure and Stability
Creators: name: Lord, S. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Fibrin structure and stability have been linked to many thrombotic diseases, including venous thromboembolism. Analysis of the molecular mechanisms that affect fibrin structure and stability became possible when Doolittle and colleagues solved the crystal structure of fibrinogen. Biochemical studies of natural and recombinant variant fibrinogens have examined the interactions that mediate the conversion of soluble fibrinogen to the insoluble fibrin network. These studies identified intermolecular interactions that control fibrin structure, though some critical events remain ambiguous. Studies show fibrin structure modulates the enzymatic lysis of the fibrin network, so the molecular mechanisms that control structure also control stability. Studies show the mechanical stability of the fibrin clot depends on the properties of the fibrin monomer, leading investigators to explore the molecular basis of the monomer’s mechanical properties. The work summarized here provides insight that might allow development of pharmaceuticals and treatments to modulate fibrin structure and stability in vivo and thereby prevent or limit thrombotic disease.
Rank $n$ swapping algebra for the $\operatorname{PSL}(n, \mathbb{R})$ Hitchin component
Creators: name: Sun, Zhe
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 53D30 (Primary), 05E99 (Secondary)

description: F. Labourie [arXiv:1212.5015] characterized the Hitchin components for $\operatorname{PSL}(n, \mathbb{R})$ for any $n>1$ by using the swapping algebra, where the swapping algebra should be understood as a ring equipped with a Poisson bracket. We introduce the rank $n$ swapping algebra, which is the quotient of the swapping algebra by the $(n+1)\times(n+1)$ determinant relations. The main results are the well-definedness of the rank $n$ swapping algebra and the "cross-ratio" in its fraction algebra. As a consequence, we use the sub fraction algebra of the rank $n$ swapping algebra generated by these "cross-ratios" to characterize the $\operatorname{PSL}(n, \mathbb{R})$ Hitchin component for a fixed $n>1$. We also show the relation between the rank $2$ swapping algebra and the cluster $\mathcal{X}_{\operatorname{PGL}(2,\mathbb{R}),D_k}$-space.
description: 22 pages, 8 figures, version 2: section 5 add
Bharatavolzia (Bharatavolziella) pallida Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydrovolziidae
Bharatavolzia
Bharatavolzia pallida

description: Bharatavolzia (Bharatavolziella) pallida Cook, 1967
Records from the study area: Maharashtra—Cook (1967); Prasad (1974); Pešić & Ranga Reddy (2009).
Habitat: Hyporheic interstitial.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 3, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
THE ROLE OF NADPH OXIDASE-DERIVED REACTIVE OXYGEN SPECIES IN AXONAL REGENERATION FOLLOWING INJURY
Creators: name: Alam, S M Sabbir
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Neurosciences not elsewhere classified
Biochemistry and cell biology not elsewhere classified

description: Although long known for their damaging effects to cell components and contribution to aging, cancer, and neurodegeneration, reactive oxygen species (ROS) have recently been found to have beneficial roles, such as mediating intracellular signaling and triggering regenerative inflammatory responses. While excessive ROS causes oxidative stress and cellular damage, an optimum ROS level is crucial for proper cell functioning, growth, and proliferation. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) is a major source of cellular ROS that has been linked to neuronal polarity, axonal growth, and nervous system development. However, the precise role of Nox-derived ROS in axonal regeneration after injury has remained unclear. Here, we tested a role for neuronal Nox in neurite regeneration following mechanical transection in cultured neurons. Using a novel hydrogen peroxide (H2O2)-sensing dye, p-bispinacolatoboron-5’-phenylpyridylthiazole (BPPT), we found that H2O2 -levels are elevated in regenerating growth cones following injury. Increased Nox2 co-localization with p40phox in the growth cone central domain suggests Nox2 activation after injury. Inhibiting Nox with pharmacological Nox inhibitor, celastrol, or reducing ROS with the chemical antioxidant N-acetyl-L-cysteine, reduced neurite regeneration rate. Higher level of H2O2 had negative effects on neurite outgrowth and regeneration. Growth cones treated with celastrol had reduced F-actin content in the growth cone periphery and T domain. Pharmacological inhibition of Nox also caused reduced activity of Src2, a redox modifiable protein that regulates actin organization and dynamics in the growth cone. Using a zebrafish larval spinal cord injury model, we found that pharmacological inhibition of Nox affects swimming behavior indicating impaired spinal cord regeneration due to the inhibition of Nox. Taken together, these findings indicate that the level of neuronal Nox-derived ROS is critical for neurite regeneration following injury. Identification of Nox downstream effectors in the growth cone is the next goal of this project to better understand the signaling pathway of Nox involved in neurite regeneration.
Blood BTEX levels and neurologic symptoms in Gulf states residents
Creators: name: Werder, E.J.
name: Blair, A.
name: Sandler, D.P.
name: McGrath, J.A.
name: Engel, L.S.
name: Kwok, R.K.
Publisher: name: Academic Press Inc.
Year: 2019

description: Background: The chemicals benzene, toluene, ethylbenzene, and xylenes (BTEX) are neuroactive. Exposures often co-occur because they share common sources. We examined neurologic effects of environmental BTEX exposure among U.S. Gulf coast residents taking into account concomitant exposures. Methods: We measured blood concentrations of BTEX in 690 Gulf state residents. Neurologic symptoms were ascertained via telephone interview. We used log-binomial regression to estimate associations between blood BTEX levels and self-reported neurologic symptoms independently for the presence of any neurologic, central (CNS), or peripheral nervous system (PNS) symptoms. We estimated associations in single chemical models mutually adjusted for co-occurring BTEX and used weighted quantile sum regression to model associations between the combined BTEX mixture and neurologic symptoms. Results: Half (49%) of participants reported at least one neurologic symptom. Each BTEX chemical was associated with increased CNS and PNS symptoms in single-chemical models comparing the highest to lowest quartile of exposure. After adjusting for coexposures, benzene was associated with CNS symptoms among all participants (PR = 2.13, 95% CI: 1.27, 3.57) and among nonsmokers (PR = 2.30, 95% CI: 1.35, 3.91). After adjusting for coexposures, associations with toluene were apparent only for reporting multiple PNS symptoms (PR = 2.00, 95% CI: 0.96, 4.16). In mixture analyses, a one-quartile increase in BTEX exposure was associated with neurologic symptoms (OR = 1.47, 95% CI: 1.11, 1.98). The weighted quantile sum index weighted benzene most heavily, which was consistent with single chemical analyses. Conclusions: Increasing blood benzene concentration was associated with increased prevalence of CNS symptoms. In this sample, BTEX-associated neurologic effects are likely driven by exposure to benzene and, to a lesser extent, toluene.
Overexpression of the Cell Cycle Inhibitor p16INK4a Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice
Creators: name: Whinna, H. C.
name: Church, F. C.
name: Owens, A. P.
name: Sharpless, N. E.
name: Cardenas, J. C.
name: Krishnamurthy, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Age-associated cellular senescence is thought to promote vascular dysfunction. p16INK4a is a cell cycle inhibitor that promotes senescence and is upregulated during normal aging. In this study, we examine the contribution of p16INK4a overexpression on venous thrombosis.
Masses of physical scalars in two Higgs doublet models
Creators: name: Biswas, Ambalika
name: Lahiri, Amitabha
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We find bounds on scalar masses resulting from a criterion of naturalness, in a broad class of two Higgs doublet models (2HDMs). Specifically, we assume the cancellation of quadratic divergences in what are called the type I, type II, lepton-specific and flipped 2HDMs, with an additional U(1) symmetry. This results in a set of relations among masses of the physical scalars and coupling constants, a generalization of the Veltman conditions of the Standard Model. Assuming that the lighter $CP$-even neutral Higgs particle is the observed scalar particle of mass $\sim$125 GeV, and imposing further the constraints from the electroweak T-parameter, stability, and perturbative unitarity, we calculate the range of the mass of each of the remaining physical scalars.
description: v3: 14pp 2fig. Minor changes. Content agrees with published version
Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3-Dependent NOSTRIN Expression
Creators: name: Goel, R.
name: McCormick, M. E.
name: Newman, D.
name: Oess, S.
name: Tzima, E.
name: Fulton, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is an important regulator of cardiovascular physiology and pathology. eNOS is activated by numerous stimuli and its activity is tightly regulated. Platelet-endothelial cell adhesion molecule-1 (PECAM-1) has been implicated in regulating eNOS activity in response to shear stress. The goal of the current study is to determine the role of PECAM-1 in the regulation of basal eNOS activity.
Recombinant Human Interleukin-11 Treatment Enhances Collateral Vessel Growth After Femoral Artery Ligation
Creators: name: Srivastava, S.
name: Jha, S.
name: Wang, Z.
name: Lockyer, P.
name: Aitsebaomo, J.
name: Pi, X.
name: Patterson, C.
name: Veleva, A. N.
name: Winnik, S.
name: Faber, J. E.
name: Zhang, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We investigated the role of recombinant human interleukin-11 (rhIL-11) on in vivo mobilization of CD34+/VEGFR2+ mononuclear cells and collateral vessel remodeling in mouse model of hindlimb ischemia.
Additional file 1 of From purists to pragmatists: a qualitative evaluation of how implementation processes and contexts shaped the uptake and methodological adaptations of a maternal and neonatal quality improvement programme in South Africa prior to, and during COVID-19
Creators: name: Odendaal, Willem
name: Chetty, Terusha
name: Goga, Ameena
name: Tomlinson, Mark
name: Singh, Yages
name: Marshall, Carol
name: Kauchali, Shuaib
name: Pillay, Yogan
name: Makua, Manala
name: Hunt, Xanthe
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1
TRANSACTION COSTS OF COMMUNITY PARTICIPATION FOR THE DEVELOPMENT OF CULTURE-BASED FISHERIES IN VILLAGE RESERVOIRS OF SRI LANKA
Creators: name: Gunasekara, Udeni
Publisher: name: figshare
Year: 2022
Subjects: subject: 70401 Aquaculture
subject: FOS: Agriculture, forestry and fisheries
subject: 70402 Aquatic Ecosystem Studies and Stock Assessment
subject: 70107 Farming Systems Research
subject: FOS: Other agricultural sciences
subject: 70403 Fisheries Management

description: Results show that the aquaculture committees generate the highest total revenue and the highest net profit among all other arrangements. This study provides important insights into the cost and benefits associated with different management approaches.
Self-reported myocardial infarction and fatal coronary heart disease among oil spill workers and community members 5 years after Deepwater Horizon
Creators: name: Keil, A.P.
name: Engel, L.S.
name: Richardson, D.B.
name: Gammon, M.D.
name: Strelitz, J.
name: Sandler, D.P.
name: Heiss, G.
name: Kwok, R.K.
Publisher: name: Academic Press Inc.
Year: 2019

description: Background: Chemical, physical and psychological stressors due to the 2010 Deepwater Horizon oil spill may impact coronary heart disease (CHD) among exposed populations. Using longitudinal information from two interviews in the Gulf Long Term Follow-up (GuLF) STUDY, we assessed CHD among oil spill workers and community members. Objective: To assess the associations between duration of oil spill clean-up work, residential proximity to the oil spill, and incidence of self-reported myocardial infarction or fatal CHD. Methods: Among respondents with two GuLF STUDY interviews (n = 21,256), there were 395 first incident heart disease events (self-reported myocardial infarction or fatal CHD) across 5 years. We estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for associations with duration of oil spill clean-up work and residential proximity to the oil spill. To assess potential impacts of non-response, we compared covariate distributions for those who did (n = 21,256) and did not (n = 10,353) complete the second interview and used inverse probability (IP) of censoring weights to correct for potential non-response bias. Results: Living in proximity to the oil spill (vs. living further away) was associated with heart disease, with [HR(95%CI) = 1.30(1.01–1.67)] and without [1.29(1.00–1.65)] censoring weights. For work duration, hazard of heart disease appeared to be higher for those who worked > 180 days (vs. 1–30 days), with and without censoring weights [1.43(0.91–2.25) and 1.36(0.88–2.11), respectively]. Associations persisted throughout the 5-year follow-up. Conclusions: Residential proximity to the spill and duration of clean-up work were associated with a suggested 29–43% higher hazard of heart disease events. Associations were robust to censoring.
Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation
Creators: name: Mack, C. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Extensive studies over the last 30 years have demonstrated that vascular smooth muscle cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of environmental cues. The identification of the signaling mechanisms by which these environmental cues regulate SMC phenotype has been more difficult because of our incomplete knowledge of the transcription mechanisms that regulate SMC-specific gene expression. However, recent advances in this area have provided significant insight, and the goal of this review is to summarize the signaling mechanisms by which extrinsic cues control SMC differentiation.
Dynamics of Two-Dimensional $\mathcal{N}=(2,2)$ Supersymmetric Theories with Semichiral Superfields I
Creators: name: Nian, Jun
name: Zhang, Xinyu
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze the dynamics of a general two-dimensional $\mathcal{N}=(2,2)$ gauged linear sigma model with semichiral superfields. By computing the elliptic genera, we study the vacuum structure of the model. The result coincides with the model without using semichiral superfields. We also show that the low energy effective twisted superpotential contributed by semichiral superfields vanishes, whether we turn on twisted masses or not.
description: 25 pages; v2 with minor revision, references added
Bmper Inhibits Endothelial Expression of Inflammatory Adhesion Molecules and Protects Against Atherosclerosis
Creators: name: Schisler, J. C.
name: Pi, X.
name: Lockyer, P.
name: Chen, Z.
name: Tzima, E.
name: Moser, M.
name: Patterson, C.
name: Sweet, D. T.
name: Willis, M. S.
name: Homeister, J. W.
name: Russell, B.
name: Carey, S.
name: Dyer, L. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Bone morphogenetic proteins (Bmps) are important mediators of inflammation and atherosclerosis, though their mechanism of action is not fully understood. To better understand the contribution of the Bmp signaling pathway plays in vascular inflammation, we investigated the role of Bmper (Bmp-endothelial cell precursor-derived regulator), an extracellular Bmp modulator, in an induced in vivo model of inflammation and atherosclerosis.
Critical Review of Mouse Models of Venous Thrombosis
Creators: name: Diaz, J. A.
name: Obi, A. T.
name: Mackman, N.
name: Wrobleski, S. K.
name: Wakefield, T. W.
name: Myers, D. D.
name: Henke, P. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.
Additional file 1 of Guideline on multimodal rehabilitation for patients with post-intensive care syndrome
Creators: name: Renner, Caroline
name: Jeitziner, Marie-Madlen
name: Albert, Monika
name: Brinkmann, Sabine
name: Diserens, Karin
name: Dzialowski, Imanuel
name: Heidler, Maria-Dorothea
name: Lück, Martina
name: Nusser-Müller-Busch, Ricki
name: Sandor, Peter S.
name: Schäfer, Andreas
name: Scheffler, Bettina
name: Wallesch, Claus
name: Zimmermann, Gudrun
name: Nydahl, Peter
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1. Table S1: Authors’ Involvement. Table S2: AGREE Reporting Checklist.
High-Resolution Association Mapping of Atherosclerosis Loci in Mice
Creators: name: Lusis, A. J.
name: Wang, X.
name: Kostem, E.
name: Erbilgin, A.
name: Guan, B.
name: Neuhaus, I.
name: Bennett, B. J.
name: Eskin, E.
name: Orozco, L.
name: Dallinga, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To fine map previously identified quantitative trait loci (QTL) affecting atherosclerosis in mice using association analysis.
Time-dependent thermal transport theory
Creators: name: Biele, Robert
name: D'Agosta, Roberto
name: Rubio, Angel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Understanding thermal transport in nanoscale systems presents important challenges to both theory and experiment. In particular, the concept of local temperature at the nanoscale appears difficult to justify. Here, we propose a novel theoretical approach where we replace the temperature gradient with controllable external black-body radiations. The theory recovers known physical results, for example the linear relation between the thermal current and the temperatures difference of two black-bodies. Furthermore, our theory is not limited to the linear regime and goes beyond accounting for non linear effects and transient phenomena. In the strong coupling and large temperature gradients, we show that there is a maximum energy current that the system can sustain and we recover the Kramers' turnover. Since the present theory is general and can be adapted to describe both electron and phonon dynamics, it provides a first step towards a unified formalism for investigating thermal and electronic transport.
description: 5 pages, 4 figures, revtex4-1
Mitochondrial Oxidative Stress in Aortic Stiffening With Age: The Role of Smooth Muscle Cell Function
Creators: name: Molnar, K. C.
name: Zhou, R.-H.
name: Rojas, M.
name: Tong, H.
name: Runge, M. S.
name: Vendrov, A. E.
name: Madamanchi, N. R.
name: Carter, J. D.
name: Stouffer, G. A.
name: Niu, X.-L.
name: Tchivilev, I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Age-related aortic stiffness is an independent risk factor for cardiovascular diseases. Although oxidative stress is implicated in aortic stiffness, the underlying molecular mechanisms remain unelucidated. Here, we examined the source of oxidative stress in aging and its effect on smooth muscle cell (SMC) function and aortic compliance using mutant mouse models.
Exposure to Total Hydrocarbons during Cleanup of the Deepwater Horizon Oil Spill and Risk of Heart Attack across 5 Years of Follow-up
Creators: name: Heiss, G.
name: Stewart, P.A.
name: Engel, L.S.
name: Sandler, D.P.
name: Kwok, R.K.
name: Keil, A.P.
name: Stenzel, M.R.
name: Richardson, D.B.
name: Strelitz, J.
name: Gammon, M.D.
Publisher: name: Oxford University Press
Year: 2019

description: Exposure to total hydrocarbons (THC) and volatile organic compounds from air pollution is associated with risk of coronary heart disease. THC exposure from oil spills might be similarly associated, but no research has examined this. We assessed the relationship between THC exposure during the response and cleanup of the Deepwater Horizon oil spill (Gulf of Mexico) and heart attack risk among 24,375 oil spill workers enrolled in the Gulf Long-Term Follow-up Study. There were 312 first heart attacks (self-reported physician-diagnosed myocardial infarction, or fatal coronary heart disease) ascertained during the study period (2010-2016). THC exposures were estimated using a job-exposure matrix incorporating self-reported activities and personal air measurements. We used Cox proportional hazards regression to estimate hazard ratios, with inverse-probability weights to account for confounding and censoring. Maximum THC levels of ≥0.30 parts per million (ppm) were associated with heart attack risk, with a 1.8-fold risk for exposure of ≥3.00 ppm versus <0.30 ppm (hazard ratio = 1.81, 95% confidence interval: 1.11, 2.95). The risk difference for highest versus lowest THC level was 10 excess cases per 1,000 workers. This is the first study of the persistent health impacts of THC exposure during oil spill work, and results support increased protection against oil exposure during cleanup of future spills.
Federal Programs Supporting Substate Regionalism: 1977-79
Creators: name: Reid, J. Norman
name: Stam, Jerome M.
name: Honadle, Beth W.
name: Reid, J. Norman
name: Stam, Jerome M.
name: Honadle, Beth W.
Publisher: name: Unknown
Year: 1980
Subjects: subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: Environmental Economics and Policy
subject: Health Economics and Policy
subject: Multicounty districts
subject: Governmental aid
subject: Federal
subject: Programs
subject: Planning
subject: Grants
subject: Regional
subject: Local governments
subject: Economic development
subject: Rural development

description: This paper presents a summary of a study of Federal programs supporting multicounty substate regional activities. The study identified 39 Federal programs supporting substate regionalism that were operating during the 1977-79 period. The programs were identified on the basis of five criteria: (1) Federal connection with regional activities, (2) multicounty area focus, (3) planning and policy development focus, (4) local control, and (5) a continuing nature. The paper presents an overview of the study, identifies the 39 programs, and discusses their key features. Detailed analysis of the programs is available in other reports.
description: Prepared for presentation at the annual meetings of the American Society for Public Administration, San Francisco, California, April 14, 1980.
Pro- and Antiatherogenic Effects of a Dominant-Negative P465L Mutation of Peroxisome Proliferator-Activated Receptor-  in Apolipoprotein E-Null Mic
Creators: name: McNair, M.
name: Wilhelm, C.
name: Johnson, L. A.
name: Maeda, N.
name: Nipp, C. T.
name: Pendse, A. A.
name: Kim, H.-S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The dominant-negative mutation, P467L, in Peroxisome Proliferator Activated Receptor gamma (PPARγ) affects adipose tissue distribution, insulin sensitivity and blood pressure in heterozygous humans. We hypothesized that the equivalent mutation, PPARγ-P465L, in mice will worsen atherosclerosis.
Hydrovolzia infringata Walter 1928
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydrovolziidae
Hydrovolzia
Hydrovolzia infringata

description: Hydrovolzia infringata Walter, 1928
Records from the study area: West Bengal—Walter (1928); Prasad (1974).
Habitat: In mosses in a stream.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 3, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Rap1-Rac1 Circuits Potentiate Platelet Activation
Creators: name: Leblond, B.
name: Ouellette, T. D.
name: Andre, P.
name: Conley, P. B.
name: Boulaftali, Y.
name: Stefanini, L.
name: Bergmeier, W.
name: Holinstat, M.
name: Desire, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The goal of this study was to investigate the potential crosstalk between Rap1 and Rac1, 2 small GTPases central to platelet activation, particularly downstream of the collagen receptor GPVI.
Predictors of blood volatile organic compound levels in Gulf coast residents article
Creators: name: Gam, K.B.
name: Kwok, R.K.
name: Ekenga, C.C.
name: Curry, M.D.
name: Birnbaum, L.S.
name: Chambers, D.M.
name: Sandler, D.P.
name: Engel, L.S.
name: Blair, A.
name: Miller, A.K.
name: Werder, E.J.
Publisher: name: Nature Publishing Group
Year: 2018

description: To address concerns among Gulf Coast residents about ongoing exposures to volatile organic compounds, including benzene, toluene, ethylbenzene, o-xylene, and m-xylene/p-xylene (BTEX), we characterized current blood levels and identified predictors of BTEX among Gulf state residents. We collected questionnaire data on recent exposures and measured blood BTEX levels in a convenience sample of 718 Gulf residents. Because BTEX is rapidly cleared from the body, blood levels represent recent exposures in the past 24 h. We compared participants' levels of blood BTEX to a nationally representative sample. Among nonsmokers we assessed predictors of blood BTEX levels using linear regression, and predicted the risk of elevated BTEX levels using modified Poisson regression. Blood BTEX levels in Gulf residents were similar to national levels. Among nonsmokers, sex and reporting recent smoky/chemical odors predicted blood BTEX. The change in log benzene was -0.26 (95% CI: -0.47, -0.04) and 0.72 (0.02, 1.42) for women and those who reported odors, respectively. Season, time spent away from home, and self-reported residential proximity to Superfund sites (within a half mile) were statistically associated with benzene only, however mean concentration was nearly an order of magnitude below that of cigarette smokers. Among these Gulf residents, smoking was the primary contributor to blood BTEX levels, but other factors were also relevant.
Additional file 1 of Incidence and outcomes of critical illness in indigenous peoples: a systematic review and meta-analysis
Creators: name: Bowker, Samantha L.
name: Williams, Kienan
name: Volk, Auriele
name: Auger, Leonard
name: Lafontaine, Alika
name: Dumont, Paige
name: Wingert, Aireen
name: Davis, Amanda
name: Bialy, Liza
name: Wright, Erica
name: Oster, Richard T.
name: Bagshaw, Sean M.
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1: File S1. Full search strategy and search terms. File S2. Risk of bias assessments for included studies, using the Newcastle–Ottawa Scale. File S3. Summary of the Aboriginal and Torres Strait Islander Quality Assessment Tool appraisal. File S4. Ancillary analysis of outcomes not included in the main manuscript. File S5. GRADE evidence profile comparing Indigenous vs. non-Indigenous populations for the primary outcomes. File S6. Forest plots for of Indigenous vs. non-Indigenous for ICU mortality (Figure s6A), ICU Length of Stay (Figure s6B), and IMV (Figure s6C): subgroup analysis by indication. File S7. Forest plots of Indigenous vs. non-Indigenous populations among an obstetric critically ill population for: ICU mortality (Figure s7A), ICU LOS (Figure s7B), and IMV (Figure s7C). File S8. Egger’s Funnel plot for small study bias.
Development of a total hydrocarbon ordinal job-exposure matrix for workers responding to the Deepwater Horizon disaster: The GuLF STUDY
Creators: name: Banerjee, S.
name: Groth, C.P.
name: Kwok, R.K.
name: Stenzel, M.R.
name: Stewart, P.A.
name: Ramachandran, G.
name: Sandler, D.P.
name: Engel, L.S.
name: Huynh, T.B.
name: Blair, A.
Publisher: name: Nature Publishing Group
Year: 2018

description: The GuLF STUDY is a cohort study investigating the health of workers who responded to the Deepwater Horizon oil spill in the Gulf of Mexico in 2010. The objective of this effort was to develop an ordinal job-exposure matrix (JEM) of airborne total hydrocarbons (THC), dispersants, and particulates to estimate study participants' exposures. Information was collected on participants' spill-related tasks. A JEM of exposure groups (EGs) was developed from tasks and THC air measurements taken during and after the spill using relevant exposure determinants. THC arithmetic means were developed for the EGs, assigned ordinal values, and linked to the participants using determinants from the questionnaire. Different approaches were taken for combining exposures across EGs. EGs for dispersants and particulates were based on questionnaire responses. Considerable differences in THC exposure levels were found among EGs. Based on the maximum THC level participants experienced across any job held, 1/414% of the subjects were identified in the highest exposure category. Approximately 10% of the cohort was exposed to dispersants or particulates. Considerable exposure differences were found across the various EGs, facilitating investigation of exposure-response relationships. The JEM is flexible to allow for different assumptions about several possibly relevant exposure metrics.