cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Module-based regularization improves Gaussian graphical models when observing noisy data
Creators: name: Neuman, Magnus
name: Calatayud, Joaquín
name: Tasselius, Viktor
name: Rosvall, Martin
Publisher: name: figshare
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. Sample list.
Kant with Michael Fried: Feeling, Absorption, and Interiority in the Critique of Judgment
Creators: name: Ostas, Magdalena
Publisher: name: Humanities Commons
Year: 2014
Subjects: subject: Aesthetics--Philosophy
subject: Aesthetics
subject: Kant, Immanuel, 1724-1804
subject: Art
subject: Art criticism

description: While the greater part of criticism and reflection on Kant takes the question of aesthetics in the Critique of Judgment to center on the subject’s relation to art, art is not actually Kant’s model of aesthetic experience in the text.  This essay argues that the The Critique of Judgment, in other words, cannot simply be understood as Kant’s engagement with the realm of what we understand by aesthetics. Rather, an aesthetic object for Kant constitutes itself as aesthetic object only in relation to a particular kind of subject or unique experience of the subject. Aesthetic experience for Kant is an economy between subject and object rather than an encounter with what we understand by beauty. Aesthetics, then, rather than being the division of Kant’s philosophy concerned with art or the beautiful becomes, instead, a mode or a displaced way of his posing questions about subjectivity more generally. This essay shows that this economy between subject and object bears a striking resemblance to the shift between artwork and beholder that Michael Fried claims transpires at about the same period in the history of art and aesthetics.
AGENT-BASED MODELING TO ASSESS THE EFFECTIVENESS OF RUN HIDE FIGHT
Creators: name: Lee, Jae Yong
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Modelling and simulation

description: The 1999 Columbine High School shooting was a bold reminder which emphasized the importance of active shooter preparedness for the first responder communities and the general public. Since Columbine, the preparedness for active shooter incidents (ASIs) both in the public and private sectors proactively took place. Currently, the RUN.HIDE.FIGHT.{\textregistered} (RHF) response for unarmed individuals is implemented as part of the emergency response throughout the United States. Despite the RHF's nationwide implementation, there is a lack of literature that supports the effectiveness of RHF to lower casualty rates during ASIs. This thesis examined casualty differences of RHF and the shooters' discharge interval by creating the incidents that have occurred in the library during the 1999 Columbine High School shooting with AnyLogic's agent-based modeling capabilities. Recreating ASI in a virtual environment naturally removes the participants’ physiological and psychological implications. Additionally, the flexibility of agent-based modeling allows validating the model based on the historical events than to run various what-if scenarios. The outcome of this thesis examines the effectiveness of RHF by comparing the output data from the actual event to models with RHF implementation.
Supplemental material for this article is available online.
Creators: name: Arif, Adeel
name: Arif, Amber
name: Fasciglione, Kimberly Anne
name: Jafri, Farrukh Nadeem
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Science Policy

description: Supplemental Material for The Iterative Development and Testing of an Interactive Mobile Application for Skill Retention of Cardiopulmonary Resuscitation Among High School Students: A Pilot Study by Adeel Arif, Amber Arif, Kimberly Anne Fasciglione and Farrukh Nadeem Jafri, in Simulation & Gaming
Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa
Creators: name: Bielecki, Piotr
name: Jensen, Vanessa
name: Schulze, Wiebke
name: Gödeke, Julia
name: Strehmel, Janine
name: Eckweiler, Denitsa
name: Nicolai, Tanja
name: Bielecka, Agata
name: Wille, Thorsten
name: Gerlach, Roman
name: Häussler, Susanne
Publisher: name: Robert Koch-Institut
Year: 2015
Subjects: subject: Bacterial
subject: Bacterial Proteins/metabolism
subject: DNA-Binding Proteins/genetics
subject: DNA-Binding Proteins/metabolism
subject: Bacterial Proteins/genetics
subject: Base Sequence
subject: Signal Transduction
subject: Transcription Genetic
subject: Luciferases/genetics
subject: Binding Sites
subject: Consensus Sequence
subject: Gene Expression Regulation
subject: Luciferases/analysis
subject: Promoter Regions Genetic
subject: Pseudomonas aeruginosa/genetics
subject: Pseudomonas aeruginosa/metabolism
subject: Regulon
subject: 610 Medizin

description: Two-component systems (TCS) serve as stimulus-response coupling mechanisms to allow organisms to adapt to a variety of environmental conditions. The opportunistic pathogen Pseudomonas aeruginosa encodes for more than 100 TCS components. To avoid unwanted cross-talk, signaling cascades are very specific, with one sensor talking to its cognate response regulator (RR). However, cross-regulation may provide means to integrate different environmental stimuli into a harmonized output response. By applying a split luciferase complementation assay, we identified a functional interaction of two RRs of the OmpR/PhoB subfamily, namely PhoB and TctD in P. aeruginosa. Transcriptional profiling, ChIP-seq analysis and a global motif scan uncovered the regulons of the two RRs as well as a quadripartite binding motif in six promoter regions. Phosphate limitation resulted in PhoB-dependent expression of the downstream genes, whereas the presence of TctD counteracted this activation. Thus, the integration of two important environmental signals e.g. phosphate availability and the carbon source are achieved by a titration of the relative amounts of two phosphorylated RRs that inversely regulate a common subset of genes. In conclusion, our results on the PhoB and TctD mediated two-component signal transduction pathways exemplify how P. aeruginosa may exploit cross-regulation to adapt bacterial behavior to complex environments.
Revitalisation of Cantonese Culture and Language in Aotearoa New Zealand
Creators: name: Wong She, Chelsea
name: Wong, Chelsea
name: Sew Hoy, Debbie
name: Tang, Eda
name: Chan, Samuel
name: Wong, Sidney
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470401
subject: Applied linguistics and educational linguistics

description: Our mission is to revitalise the Cantonese culture and language in Aotearoa New ZealandThe purpose of this presentation is to share our mission in revitalising Cantonese culture and language for all learners and Cantonese speakers across Aotearoa New Zealand. We believe the Cantonese culture and language is at risk of being lost through the generations in New Zealand if we do not take active steps now to retain and pass down the knowledge and language.Presented at 81st New Zealand Chinese Association Conference/Annual General Meeting, 22 June 2024, Wellington, New Zealand
TRPV4 Implications in Inflammation and Hydrocephalic Neurological Disease
Creators: name: Simpson, Stefanie J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Animal neurobiology
Biochemistry and cell biology not elsewhere classified
Comparative physiology
Neurosciences not elsewhere classified
Plant cell and molecular biology
Animal cell and molecular biology
Animal physiology - biophysics
Animal physiology - cell
Animal physiology - systems

description: Hydrocephalus is a debilitating disease characterized by an increase in cerebrospinal fluid (CSF) in the brain, leading to increases in pressure that can ultimately result in death. Current treatments for hydrocephalus include only invasive brain surgery. Therefore, the need for a pharmaceutical therapy is great. In order to develop a suitable treatment, we first must be able to study the disease and the mechanisms by which it develops. By characterizing appropriate in vivo and in vitro models, we are better able to study this disease. In this thesis, the Wpk rat model and the PCP-R cell line are described as such appropriate models. In addition to suitable models, we also require a target for drug treatment. Transient Receptor Potential Vanilloid 4 (TRPV4) is a non-selective cation ion channel present in the main CSF-producing organ in the brain, the choroid plexus (CP). Preliminary data suggest this channel plays a role in the development of hydrocephalus. In the following work, some of the mechanisms by which TRPV4 functions in the brain are also described, including through calcium-sensitive potassium channels and inflammation. From this research, we are able to achieve a better understanding of the function of TRPV4 and how it can affect the development and progression of hydrocephalus.
People's Opinion on the Issue of Traffic Muang Nong Khai Municipality In Nong Khai
Creators: name: Somsin, Kasem
name: Saowalak Kosolkittiamporn
Publisher: name: Master of Arts Program in Peace Studies, Mahachulalongkornrajavidyalaya University
Year: 2017
Subjects: People’s Opinion; Traffic problems

description: Journal of MCU Peace Studies, 5, sp1
The Relationship Between Satisfaction and Organizational Commitment to the Welfare of the Employees of Glory Kan Co., Ltd.
Creators: name: Supuassorn Ranguppai
Publisher: name: Master of Arts Program in Peace Studies, Mahachulalongkornrajavidyalaya University
Year: 2017
Subjects: Welfare; Employee; Engagement

description: Journal of MCU Peace Studies, 5, sp1
Wohnumfeld – Stolperstein oder Weg zum gesunden Altern?
Creators: name: Strobl, Ralf
name: Maier, Werner
name: Mielck, Andreas
name: Fuchs, Judith
name: Richter-Kornweitz, A.
name: Gostomzyk, J.
name: Grill, Eva
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2014
Subjects: subject: Altersforschung
subject: Teilhabe
subject: Wohnumfeld
subject: Regionalkonferenz
subject: Gesundes Altern
subject: Research on ageing
subject: Participation
subject: Living environment
subject: Regional conference
subject: Healthy ageing
subject: 610 Medizin

description: Neben einer guten medizinischen Versorgung ist die Struktur des Wohnumfeldes von zentraler Bedeutung, um soziale Teilhabe älterer Menschen zu fördern. Für die Kommunen bedeutet dies, dass sie der altersgerechten Gestaltung des direkten Wohnumfelds hohe Priorität einräumen sollten. Am 1. Oktober 2013 wurden auf der Regionalkonferenz „Wohnumfeld, Alter und Gesundheit“ im Augsburger Rathaus verschiedene Ergebnisse der KORA-Age-Studie zum Thema Teilhabe und Wohnumfeld vorgestellt und mit politischen Entscheidungsträgern aus Augsburg und Seniorenvertretern aus der Region diskutiert. Die Studie untersuchte den Zusammenhang zwischen Wohnumfeld und Teilhabe mittels zweier unterschiedlicher Ansätze: qualitative Ergebnisse aus Fokusgruppendiskussionen und quantitative Ergebnisse basierend auf Telefoninterviews und der Verwendung eines Geoinformationssystems. Die Ergebnisse wurden durch Beiträge aus regionaler und überregionaler Sicht ergänzt. In der Diskussion ergab sich, dass nur mit einem breiten Spektrum an Maßnahmen ein seniorenfreundliches Wohnumfeld geschaffen werden kann, sodass einerseits physische Barrieren abgebaut und andererseits das Gemeinschaftsgefühl, der nachbarschaftliche Zusammenhalt und das Miteinander gefördert werden.
description: In addition to good medical care, living environment is of central importance in encouraging social participation among older people. Therefore, municipalities should prioritise the age-appropriate design of living environments. Results of the KORA Age study were presented at the regional conference “Living environment, age and health” in the Augsburg town hall on October 1, 2013. The results on participation and living environment were discussed with local policy makers and senior citizens’ representatives from Augsburg and two surrounding regions. The study examined the impact of living environment on participation using two different approaches: qualitative findings from focus group discussions and quantitative findings based on telephone interviews and the use of a geographic information system. The results were complemented by contributions from a regional and national perspective. It was stressed in the closing discussion that a senior-friendly living environment can only be created by using a broad range of different measures. On the one hand physical barriers need to be removed, while at the same time the sense of community, neighborhood cohesion and solidarity should be encouraged further.
The People's Participation on the Development Plan Making of Bandue Municipality, Muang Nong khai, Nongkhai province
Creators: name: Sunetiluk Yoktep
name: Yupaporn Yupas
Publisher: name: Master of Arts Program in Peace Studies, Mahachulalongkornrajavidyalaya University
Year: 2017
Subjects: People’s Participation; the Development Plan Making

description: Journal of MCU Peace Studies, 5, sp1
Safety issues of Donepezil combined with Memantine in Alzheimer’s disease population: real-world pharmacovigilance
Creators: name: Zeng, Yi
name: Liu, Bingshuo
name: Zhou, Lisi
name: Zeng, Wenling
name: Tian, Xiaona
name: Jiang, Jiazhen
name: Dai, Dandan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Mental Health

description: Alzheimer’s disease (AD) is the most common form of dementia. The combination of Donepezil and Memantine is the only FDA-approved therapy for AD, but its adverse drug reactions (ADRs) lack systematic analysis. This study carried out drug combination analysis for AD population to provide evidence support for clinical safety of drug use. Using FAERS database reports (January 2004–January 2024) with Donepezil and Memantine as primary suspected drugs, four disproportionality analysis methods – ROR, PRR, BCPNN, and EBGM – were applied to identify positive ADR signals. Subgroup analyses were conducted by age and gender. A total of 712 reports were analyzed (54.6% female, 55.1% aged 65–85). Across the AD population, 42 ADRs were identified, including hypertensive crisis, hyperglycemia, hyperosmolar nonketotic syndrome, proteinuria, and hydronephrosis, many of which were newly reported. Subgroup analysis revealed prostate hypertrophy, acute kidney injury, and cerebral infarction in males, while females experienced more severe cardiovascular events, such as complete AV block and ventricular extrasystole. Additional ADRs included hyperkalemia, sinus bradycardia, and extrapyramidal disorders. Despite partial consistency of combined ADRs for Donepezil and Memantine with instructions, new ADR signals emerged, with significant differences in AD subgroups.
Factors Affecting Debt Burden of Farmers Tha Bo District Nong Khai
Creators: name: Sirinapha Phocapanit
name: Sanya Kenaphoom
Publisher: name: Master of Arts Program in Peace Studies, Mahachulalongkornrajavidyalaya University
Year: 2017
Subjects: Factors; Debt Burden; Farmers

description: Journal of MCU Peace Studies, 5, sp1
Safety issues of donepezil combined with memantine in Alzheimer’s disease population: real-world pharmacovigilance
Creators: name: Zeng, Yi
name: Liu, Bingshuo
name: Zhou, Lisi
name: Zeng, Wenling
name: Tian, Xiaona
name: Jiang, Jiazhen
name: Dai, Dandan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Mental Health

description: Alzheimer’s disease (AD) is the most common form of dementia. The combination of Donepezil and Memantine is the only FDA-approved therapy for AD, but its adverse drug reactions (ADRs) lack systematic analysis. This study carried out drug combination analysis for AD population to provide evidence support for clinical safety of drug use. Using FAERS database reports (January 2004–January 2024) with Donepezil and Memantine as primary suspected drugs, four disproportionality analysis methods – ROR, PRR, BCPNN, and EBGM – were applied to identify positive ADR signals. Subgroup analyses were conducted by age and gender. A total of 712 reports were analyzed (54.6% female, 55.1% aged 65–85). Across the AD population, 42 ADRs were identified, including hypertensive crisis, hyperglycemia, hyperosmolar nonketotic syndrome, proteinuria, and hydronephrosis, many of which were newly reported. Subgroup analysis revealed prostate hypertrophy, acute kidney injury, and cerebral infarction in males, while females experienced more severe cardiovascular events, such as complete AV block and ventricular extrasystole. Additional ADRs included hyperkalemia, sinus bradycardia, and extrapyramidal disorders. Despite partial consistency of combined ADRs for Donepezil and Memantine with instructions, new ADR signals emerged, with significant differences in AD subgroups.
Additional file 1 of European expert consensus recommendations on the primary care use of direct oral anticoagulants in patients with venous thromboembolism
Creators: name: Patrice, Carter
name: Ahmet, Fuat
name: Sylvia, Haas
name: Elizabeth, Smyth
name: Carlos, Brotons
name: Frank, Cools
name: Rupert, Bauersachs
name: Richard, Hobbs F. D.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Pharmacology
Science Policy

description: Supplementary Material 1
Keats and the Impersonal Craft of Writing
Creators: name: Ostas, Magdalena
Publisher: name: unknown
Year: 2009
Subjects: subject: Poetics
subject: Lyric poetry
subject: Poetry
subject: Romanticism

description: This analysis of Keats's Odes of 1819 and discussion of Keats's late lyrical style—what I term his "impersonal" craft of writing throughout—accounts for the draw toward the visual idiom in Keats criticism. This essay shows why Keats's poetics draws what critics instinctively import as visual idioms and focuses on the unique grammar of enunciation and representation in his verse. Keats's grammar of enunciation is never tied to a first-person persona or self of utterance, and this essay brings out several aspects of the critical significance of this style of writing, the logic of subjectivity that it embodies, and the late moment in the Romantic tradition that it articulates.
The Way to Enhance Quality of Life for Attaining Peace According to the Noble Eightfold Path: A case Study of Camp Son Religious Development Center in Petchabun Province
Creators: name: Wijit Junlaphan
Publisher: name: Master of Arts Program in Peace Studies, Mahachulalongkornrajavidyalaya University
Year: 2017
Subjects: Enhancing quality of Life; Peace; the Noble Eightfold Path

description: Journal of MCU Peace Studies, 5, sp1
Falldefinitionen für die Surveillance meldepflichtiger Infektionskrankheiten in Deutschland, Ausgabe 2015
Creators: name: Diercke, Michaela
name: Benzler, Justus
name: Schöneberg, Irene
name: Mücke, Ingeborg
name: Altmann, Doris
name: Claus, Hermann
name: Gilsdorf, Andreas
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2014
Subjects: subject: Surveillance
subject: Meldewesen
subject: Infektionsschutzgesetz (IfSG)
subject: Falldefinitionen
subject: Übermittlung
subject: Notification system
subject: Protection against infection act
subject: Case definitions
subject: Data transmission
subject: 610 Medizin

description: Die Falldefinitionen geben einheitliche Kriterien für die Surveillance von Infektionskrankheiten vor. Seit der letzten Überarbeitung der Gesamtausgabe (Version 2007) ist eine Aktualisierung aufgrund neuer wissenschaftlicher Erkenntnisse, veränderter Gesetzeslage, Terminologien und Klassifikationen notwendig geworden. Gleichzeitig sollten die Falldefinitionen weiter vereinheitlicht und die Arbeit in den Gesundheitsämtern vereinfacht werden. Die Überarbeitung wurde von der Abteilung für Infektionsepidemiologie des Robert Koch-Instituts (RKI) koordiniert. In mehreren Feedbackrunden wurden sowohl RKI-interne als auch externe Expertinnen und Experten aus dem Öffentlichen Gesundheitsdienst sowie medizinischen Fachgesellschaften und Laboren einbezogen. Die neue Ausgabe und eine kommentierte Version werden auf der Webseite des RKI (www.​rki.​de/​falldefinitionen​) veröffentlicht. Sie tritt am 01.01.2015 in Kraft. In diesem Beitrag werden die wichtigsten Änderungen zusammengefasst.
description: Case definitions ensure standardised criteria for the surveillance of infectious diseases in Germany. Since its last revision in 2007, an update of the complete case definition edition became necessary due to new scientific insights, changes in legislature, terminology and classification systems. At the same time, the case definition should be further standardised and work at local public health authorities should be simplified. The department for infectious disease epidemiology at the Robert Koch Institute (RKI) coordinated the revision of the case definitions. During several feedback sessions, internal RKI experts and external experts from different levels of the German public health system, as well as from medical associations and laboratories, were involved in the revision process. The new edition and an annotated version are published on the RKI website (www.​rki.​de/​falldefinitionen​). The new case definitions will become effective on 1st January 2015. The most important changes are summarised in this article.
IMPLEMENTING THE SUPERPAVE 5 ASPHALT MIXTURE DESIGN METHOD IN INDIANA
Creators: name: Patel, Harsh
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Civil engineering not elsewhere classified

description: Recent research developments have indicated that asphalt mixture durability and pavement life can be increased by modifying the Superpave asphalt mixture design method to achieve an in-place density of 95%, 2% higher than the conventional density requirements of approximately 93% (7% air voids content). Doing so requires increasing the design air voids content to 5% from the conventional requirement of 4 percent. After successful laboratory testing of this modified mixture design method, known as Superpave 5, two controlled field trials and one full scale demonstration project, the Indiana Department of Transportation (INDOT) let 12 trial projects across the six INDOT districts based on the design method. The Purdue University research team was tasked with observing the implementation of the Superpave 5 mixture design method, documenting the construction and completing an in-depth analysis of the quality control and quality assurance (QC/QA) data obtained from the projects. QC/QA data for each construction project were examined using various statistical metrics to determine construction performance with respect to INDOT Superpave 5 specifications. The data indicate that, on average, the contractors achieved 5% laboratory air voids, which coincides with the Superpave 5 recommendation of 5% laboratory air voids. However, on average, the as-constructed in-place density of 93.8% is roughly 1% less than the INDOT Superpave 5 specification. The findings of this study will benefit the future implementation of this modified mixture design method.
No Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana
Creators: name: Junglen, Sandra
name: Marklewitz, Marco
name: Zirkel, Florian
name: Wollny, Robert
name: Meyer, Benjamin
name: Heidemann, Hanna
name: Metzger, Sonja
name: Annan, Augustina
name: Dei, Dickson
name: Leendertz, Fabian H.
name: Oppong, Samuel
name: Drosten, Christian
Publisher: name: Robert Koch-Institut
Year: 2015
Subjects: subject: Animals
subject: Swine/virology
subject: Bunyaviridae Infections/blood
subject: Bunyaviridae Infections/epidemiology
subject: Bunyaviridae Infections/immunology
subject: Cote d'Ivoire/epidemiology
subject: Culicidae/pathogenicity
subject: Culicidae/virology
subject: Ghana/epidemiology
subject: Orthobunyavirus/genetics
subject: Orthobunyavirus/pathogenicity
subject: Swine/genetics
subject: Swine/immunology
subject: 610 Medizin

description: A recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes in Côte d’Ivoire and Ghana and found no evidence for infection in pigs.
Protecting Bare-metal Systems from Remote Exploitation
Creators: name: Clements, Abraham Anthony
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: System and network security
Applied computing not elsewhere classified
Digital processor architectures
Other information and computing sciences not elsewhere classified
Networking and communications

description: The Internet of Things is deploying large numbers of bare-metal systems that have no protection against memory corruption and control-flow hijacking attacks. These attacks have enabled unauthorized entry to hotel rooms, malicious control of unmanned aerial vehicles, and invasions of privacy. Using static and dynamic analysis these systems can utilize state-of-the-art testing techniques to identify and
prevent memory-corruption errors and employ defenses against memory corruption and control-flow hijacking attacks in bare-metal systems that match or exceed those currently employed on desktop systems. This is shown using three case studies.

(1) EPOXY which, automatically applies data execution prevention, diversity, stack defenses, and separating privileged code from unprivileged code using a novel
technique called privileged overlaying. These protections prevent code injection attacks, and reduce the number of privileged instruction to 0.06% verses an unprotected
application.

(2) Automatic Compartments for Embedded Systems (ACES), which automatically creates compartments that enforce data integrity and code isolation within bare-metal applications. ACES enables exploring policies to best meet security and performance requirements for individual applications. Results show ACES' can form 10s of compartments within a single thread and has a 15% runtime overhead on average.

(3) HALucinator breaks the requirement for specialized hardware to perform bare-metal system testing. This enables state-of-the-art testing techniques –e.g., coverage based fuzzing – to scale with the availability of commodity computers, leading to the discovery of exploitable vulnerabilities in bare-metal systems.

Combined, these case studies advance the security of embedded system several decades and provide essential protections for today’s connected devices.
Additional file 2 of European expert consensus recommendations on the primary care use of direct oral anticoagulants in patients with venous thromboembolism
Creators: name: Patrice, Carter
name: Ahmet, Fuat
name: Sylvia, Haas
name: Elizabeth, Smyth
name: Carlos, Brotons
name: Frank, Cools
name: Rupert, Bauersachs
name: Richard, Hobbs F. D.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Pharmacology
Science Policy

description: Supplementary Material 2
Contemporary Latinx Literatures & Cultures
Creators: name: Challener, Scott
Publisher: name: unknown
Year: 2021
Subjects: subject: United States
subject: American literature
subject: Twenty-first century
subject: Hispanic Americans--Social life and customs
subject: Culture--Study and teaching

description: This course is a study of Latinx literatures and cultures produced in the last two decades. We will concentrate our attention on how contemporary art works represent and participate in the upheavals of the twenty-first century—9/11, global economic and ecological crisis, mass migration and mass deportation, political and social mobilization, state repression, neoliberalization, border conflict, and the transformation of mass media. We will examine specific literary and cultural objects—novels, poems, plays, shows, performance art, painting, music—and the historical antagonisms that animate them. We will investigate the cultural work these objects and their authors perform. How do they project, embrace, and constitute the conflicting meanings of Latinx life today? How do they contravene, suppress, or refuse certain fantasies of the "Latin"? We will address questions about race and racialization, gender and sexuality, and assimilation and transculturation, as well as about the politics of Spanglish and Spanish and the situation of Latina/o/x artists in the global marketplace. We will conclude by looking at several works by Latin American artists that consider these questions from "beyond" the United States—that is, from outside of the political borders of the U.S., and from the margins of the canon and the culture industry.
sj-docx-1-jdr-10.1177_00220345211025242 – Supplemental material for Early Optimistic Effect in Periodontology and Implant Dentistry Trials
Creators: name: Menne, M.C.
name: Seitidis, G.
name: Faggion, C.M.
name: Mavridis, D.
name: Pandis, N.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-jdr-10.1177_00220345211025242 for Early Optimistic Effect in Periodontology and Implant Dentistry Trials by M.C. Menne, G. Seitidis, C.M. Faggion, D. Mavridis and N. Pandis in Journal of Dental Research
Contemporary Latinx Literatures & Cultures
Creators: name: Challener, Scott
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Culture--Study and teaching
subject: United States
subject: Hispanic Americans--Social life and customs
subject: American literature
subject: Twenty-first century

description: This course is a study of Latinx literatures and cultures produced in the last two decades. We will concentrate our attention on how contemporary art works represent and participate in the upheavals of the twenty-first century—9/11, global economic and ecological crisis, mass migration and mass deportation, political and social mobilization, state repression, neoliberalization, border conflict, and the transformation of mass media. We will examine specific literary and cultural objects—novels, poems, plays, shows, performance art, painting, music—and the historical antagonisms that animate them. We will investigate the cultural work these objects and their authors perform. How do they project, embrace, and constitute the conflicting meanings of Latinx life today? How do they contravene, suppress, or refuse certain fantasies of the “Latin”? We will address questions about race and racialization, gender and sexuality, and assimilation and transculturation, as well as about the politics of Spanglish and Spanish and the situation of Latina/o/x artists in the global marketplace. We will conclude by looking at several works by Latin American artists that consider these questions from “beyond” the United States—that is, from outside of the political borders of the U.S., and from the margins of the canon and the culture industry.
Complete Genome Sequence of the Gut Commensal and Laboratory Strain Enterococcus faecium 64/3
Creators: name: Bender, Jennifer K.
name: Fiedler, Stefan
name: Klare, Ingo
name: Werner, Guido
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2015
Subjects: subject: 610 Medizin

description: The genome sequence of the commensal and widely used laboratory strain Enterococcus faecium 64/3 was resolved by means of PacificBioscience and Illumina whole-genome sequencing. The genome comprises 2,575,333 bp with 2,382 coding sequences as assigned by NCBI.
Mining of adverse event signals associated with inclisiran: a post-marketing analysis based on FAERS
Creators: name: Shi, Xuezhong
name: Qiao, Ying
name: Yang, Yongli
name: Wang, Nana
name: Zhang, Yi
name: Shi, Shangxin
name: Shen, Guibin
name: Jia, Xiaocan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: This study analyzed adverse events (AEs) associated with inclisiran using the FDA’s Adverse Event Reporting System (FAERS) to detect and characterize relevant safety signals. We retrospectively extracted AE reports from the FAERS database spanning Q1 2022 to Q2 2024. Four disproportionality analysis algorithms were employed to identify AE signals for inclisiran, with subsequent comparisons made to PCSK9 monoclonal antibodies (alirocumab/evolocumab). Additionally, we examined the characteristics and onset timing of inclisiran-related AE. A total of 4,122 reports of inclisiran as the ‘primary suspected’. Compared with all other drugs, the most significant system organ class (SOC) was ‘musculoskeletal and connective tissue disorders’ (ROR = 3.64, PRR = 3.19) and the most common SOC was ‘general disorders and administration site conditions’ (n = 2,769). These two SOCs were more strongly with inclisiran than evolocumab. At the preferred term level, strong signals were detected for cellulitis gangrenous (ROR = 101.29, PRR = 101.27, IC = 6.54, EBGM = 92.91) and bladder discomfort (ROR = 12.61, PRR = 12.61, IC = 3.64, EBGM = 12.48). The median onset time for inclisiran-related AEs was 43 days (interquartile range: 7–99 days). This study enhanced our understanding of AEs to inclisiran. Future research on its long-term real-world use will offer insights into its safety.
Viral hepatitis in Germany: poor vaccination coverage and little knowledge about transmission in target groups
Creators: name: Schenkel, Karl
name: Radun, Doris
name: Bremer, Viviane
name: Bocter, Nikolaus
name: Hamouda, Osamah
Publisher: name: Robert Koch-Institut; Robert Koch-Institut, Infektionsepidemiologie
Year: 2008
Subjects: subject: Humans
subject: Adolescent
subject: Adult
subject: Aged
subject: Cross-Sectional Studies
subject: Germany
subject: Health Knowledge
subject: Attitudes
subject: Practice
subject: Health Surveys
subject: Hepatitis B/prevention & control
subject: Hepatitis B/transmission
subject: Middle Aged
subject: Vaccination/utilization
subject: Aged 80 and over
subject: 610 Medizin

description: Background: In Germany, vaccination against hepatitis B is recommended for infants, children and adolescents since 1995 and for specific target groups since 1982. Little is known about knowledge about viral hepatitis and attitudes toward hepatitis B vaccination-factors likely to influence vaccine uptake. Methods: In order to estimate vaccination coverage in adult target groups and in the overall adult population and to assess knowledge and attitudes, we conducted a nationwide cross-sectional telephone survey among 412 persons in November 2004. We defined participants as being vaccinated if they reported at least one previous vaccination against hepatitis B. Results: Vaccination coverage (vc) standardised for age, sex and residence was 29.6% in the general population and 58.2% in target groups for hepatitis B vaccination. Particular gaps in vaccine coverage were detected among health care workers (vc: 69.5%) and chronically ill persons (vc: 22.0%). Knowledge on risk factors and transmission was far below expectations, whereas the acceptance of vaccination in the majority of the population (79.0%) was good. Conclusion: We conclude that educational measures could lead to a higher vaccination uptake in adult target groups.
Supplementary Material 1 - Supplemental material for Prominent Role of Type 2 Immunity in Skin Diseases—Beyond Atopic Dermatitis
Creators: name: Belmesk, Lina
name: Muntyanu, Anastasiya
name: Cantin, Emmanuelle
name: AlHalees, Zeinah
name: Jack, Carolyn S.
name: Le, Michelle
name: Sasseville, Denis
name: Iannattone, Lisa
name: Ben-Shoshan, Moshe
name: Litvinov, Ivan
name: Netchiporouk, Elena
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, Supplementary Material 1, for Prominent Role of Type 2 Immunity in Skin Diseases—Beyond Atopic Dermatitis by Lina Belmesk, Anastasiya Muntyanu, Emmanuelle Cantin, Zeinah AlHalees, Carolyn S. Jack, Michelle Le, Denis Sasseville, Lisa Iannattone, Moshe Ben-Shoshan, Ivan Litvinov and Elena Netchiporouk in Journal of Cutaneous Medicine and Surgery
Potential drugs for reducing the occurrence of immune checkpoint inhibitor-induced interstitial lung disease: an exploratory study using the JADER and FAERS databases
Creators: name: Utsunomiya, Ayaka
name: Koseki, Takenao
name: Hatano, Masakazu
name: Kondo, Masashi
name: Imaizumi, Kazuyoshi
name: Yamada, Shigeki
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Molecular Biology
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Immune checkpoint inhibitors (ICIs) play a central role in cancer immunotherapy. However, the occurrence of immune-related adverse events, especially ICI-induced interstitial lung disease (ICI-ILD), is life-threatening and affects the effectiveness of ICI treatment. This study aimed to explore potential drugs to mitigate ICI-ILD occurrence using data from the Japanese Adverse Drug Event Report (JADER) and the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS [JAPIC AERS]). We investigated concomitant drugs that reduce ILD associated with four ICIs – nivolumab, pembrolizumab, atezolizumab, and durvalumab – across the JADER and FAERS databases. Subsequently, the identified common concomitant drugs that reduce the occurrence of ICI-ILD were detected and analyzed. We found omega-3 fatty acids, loperamide, and amlodipine as common concomitant drugs that reduced ICI-ILD occurrence in both the JADER and FAERS databases. Omega-3 fatty acids reportedly have many effects in animal models of drug-induced ILD, including their association with ILD in humans and anti-inflammatory effects against ICI-ILD. However, loperamide and amlodipine reportedly have minimal effects against ILD, thereby necessitating further evaluation. Omega-3 fatty acids have emerged as potential agents for reducing ICI-ILD occurrence, as evidenced by findings from two different pharmacovigilance databases.
sj-pdf-3-pie-10.1177_09544089211022617 - Supplemental material for Minimizing the overall loss coefficient of flat plate solar collector using energy, entropy and exergy analysis
Creators: name: Sathyakala, Ponnusamy
name: Gangadharan, Sai Sundara Krishnan
name: Kalaiarasu, Balaji
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-3-pie-10.1177_09544089211022617 for Minimizing the overall loss coefficient of flat plate solar collector using energy, entropy and exergy analysis by Ponnusamy Sathyakala, Sai Sundara Krishnan Gangadharan and Balaji Kalaiarasu in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
APPLICATIONS OF DATA MINING IN HEALTHCARE
Creators: name: Peng, Bo
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Applied computing not elsewhere classified

description: With increases in the quantity and quality of healthcare related data, data mining tools have the potential to improve people’s standard of living through personalized and pre-
dictive medicine. In this thesis we improve the state-of-the-art in data mining for several problems in the healthcare domain. In problems such as drug-drug interaction prediction
and Alzheimer’s Disease (AD) biomarkers discovery and prioritization, current methods either require tedious feature engineering or have unsatisfactory performance. New effective computational tools are needed that can tackle these complex problems.
In this dissertation, we develop new algorithms for two healthcare problems: high-order drug-drug interaction prediction and amyloid imaging biomarker prioritization in
Alzheimer’s Disease. Drug-drug interactions (DDIs) and their associated adverse drug reactions (ADRs) represent a significant detriment to the public h ealth. Existing research on DDIs primarily focuses on pairwise DDI detection and prediction. Effective computational methods for high-order DDI prediction are desired. In this dissertation, I present a deep learning based model D3I for cardinality-invariant and order-invariant high-order DDI prediction. The proposed models achieve 0.740 F1 value and 0.847 AUC value on high-order DDI prediction, and outperform classical methods on order-2 DDI prediction. These results demonstrate the strong potential of D 3 I and deep learning based models in tackling the prediction problems of high-order DDIs and their induced ADRs.
The second problem I consider in this thesis is amyloid imaging biomarkers discovery, for which I propose an innovative machine learning paradigm enabling precision medicine in this domain. The paradigm tailors the imaging biomarker discovery process to individual characteristics of a given patient. I implement this paradigm using a newly developed learning-to-rank method PLTR. The PLTR model seamlessly integrates two objectives for joint optimization: pushing up relevant biomarkers and ranking among relevant biomarkers. The empirical study of PLTR conducted on the ADNI data yields promising results to identify and prioritize individual-specific amyloid imaging biomarkers based on the individual’s structural MRI data. The resulting top ranked imaging biomarkers have the potential to aid personalized diagnosis and disease subtyping.
Role of complement and antibodies in controlling infection with pathogenic simian immunodeficiency virus (SIV) in macaques vaccinated with replication-deficient viral vector
Creators: name: Falkensammer, Barbara
name: Rubner, Barbara
name: Hiltgartner, Alexander
name: Wilflingseder, Doris
name: Stahl-Hennig, Christiane
name: Kuate, Seraphin
name: Ueberla, Klaus
name: Norley, Stephen
name: Strasak, Alexander
name: Racz, Paul
name: Stoiber, Heribert
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2009
Subjects: subject: Animals
subject: Antibodies
subject: Viral/immunology
subject: Viral/blood
subject: Adenoviruses
subject: Human/genetics
subject: Aerosols
subject: Complement System Proteins/immunology
subject: Genetic Vectors
subject: Leukemia Virus
subject: Murine/genetics
subject: Macaca mulatta
subject: Neutralization Tests
subject: Palatine Tonsil/virology
subject: SAIDS Vaccines/immunology
subject: Simian Acquired Immunodeficiency Syndrome/prevention & control
subject: Simian immunodeficiency virus/genetics
subject: Simian immunodeficiency virus/immunology
subject: Viral Load
subject: 610 Medizin

description: Background: We investigated the interplay between complement and antibodies upon priming with single-cycle replicating viral vectors (SCIV) encoding SIV antigens combined with Adeno5-SIV or SCIV pseudotyped with murine leukemia virus envelope boosting strategies. The vaccine was applied via spray-immunization to the tonsils of rhesus macaques and compared with systemic regimens. Results: Independent of the application regimen or route, viral loads were significantly reduced after challenge with SIVmac239 (p < 0.03) compared to controls. Considerable amounts of neutralizing antibodies were induced in systemic immunized monkeys. Most of the sera harvested during peak viremia exhibited a trend with an inverse correlation between complement C3-deposition on viral particles and plasma viral load within the different vaccination groups. In contrast, the amount of the observed complement-mediated lysis did not correlate with the reduction of SIV titres. Conclusion: The heterologous prime-boost strategy with replication-deficient viral vectors administered exclusively via the tonsils did not induce any neutralizing antibodies before challenge. However, after challenge, comparable SIV-specific humoral immune responses were observed in all vaccinated animals. Immunization with single cycle immunodeficiency viruses mounts humoral immune responses comparable to live-attenuated immunodeficiency virus vaccines.
Additional file 1 of An assessment of adaptation and fidelity in the implementation of an audit and feedback-based intervention to improve transition to adult type 1 diabetes care in Ontario, Canada
Creators: name: Ahmad, Syed Zain
name: Ivers, Noah
name: Zenlea, Ian
name: Parsons, Janet A.
name: Shah, Baiju R.
name: Mukerji, Geetha
name: Punthakee, Zubin
name: Shulman, Rayzel
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1. Feedback Report Template.
sj-pdf-1-sgo-10.1177_21582440211031898 – Supplemental material for Teachers’ Ratings of Students’ Learning Disabilities and Self-Reported Learned Helplessness of Polish Junior High School Students
Creators: name: Gindrich, Piotr Alfred
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-sgo-10.1177_21582440211031898 for Teachers’ Ratings of Students’ Learning Disabilities and Self-Reported Learned Helplessness of Polish Junior High School Students by Piotr Alfred Gindrich in SAGE Open
Additional file 2 of An assessment of adaptation and fidelity in the implementation of an audit and feedback-based intervention to improve transition to adult type 1 diabetes care in Ontario, Canada
Creators: name: Ahmad, Syed Zain
name: Ivers, Noah
name: Zenlea, Ian
name: Parsons, Janet A.
name: Shah, Baiju R.
name: Mukerji, Geetha
name: Punthakee, Zubin
name: Shulman, Rayzel
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 2: Table S1. Got Transition Current Assessment of Health Care Transition Activities Baseline Element Scores and Chosen Elements Targeted by Interventions. Table S2. Site Quality Improvement Initiative Summaries. Table S3. Transition Performance of Each Site Before and After Health Care Transition Process Measurement Tool Implementation. Table S4. Adaptations and modifications to site QI initiatives documented using the FRAME-IS framework.