cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prediction of Early TBI Mortality Using a Machine Learning Approach in a LMIC Population.
Creators: name: Amorim, Robson Luis
name: Oliveira, Louise Makarem
name: Malbouisson, Luis Marcelo
name: Nagumo, Marcia Mitie
name: Simoes, Marcela
name: Miranda, Leandro
name: Bor-Seng-Shu, Edson
name: Beer-Furlan, Andre
name: De Andrade, Almir Ferreira
name: Rubiano, Andres M
name: Teixeira, Manoel Jacobsen
name: Kolias, Angelos G
name: Paiva, Wellingson Silva
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Mortality
Prognostic
Traumatic brain injury
Machine Learning
Lmics

description: Background: In a time when the incidence of severe traumatic brain injury (TBI) is increasing in low- to middle-income countries (LMICs), it is important to understand the behavior of predictive variables in an LMIC's population. There are few previous attempts to generate prediction models for TBI outcomes from local data in LMICs. Our study aim is to design and compare a series of predictive models for mortality on a new cohort in TBI patients in Brazil using Machine Learning. Methods: A prospective registry was set in São Paulo, Brazil, enrolling all patients with a diagnosis of TBI that require admission to the intensive care unit. We evaluated the following predictors: gender, age, pupil reactivity at admission, Glasgow Coma Scale (GCS), presence of hypoxia and hypotension, computed tomography findings, trauma severity score, and laboratory results. Results: Overall mortality at 14 days was 22.8%. Models had a high prediction performance, with the best prediction for overall mortality achieved through Naive Bayes (area under the curve = 0.906). The most significant predictors were the GCS at admission and prehospital GCS, age, and pupil reaction. When predicting the length of stay at the intensive care unit, the Conditional Inference Tree model had the best performance (root mean square error = 1.011), with the most important variable across all models being the GCS at scene. Conclusions: Models for early mortality and hospital length of stay using Machine Learning can achieve high performance when based on registry data even in LMICs. These models have the potential to inform treatment decisions and counsel family members. Level of evidence: This observational study provides a level IV evidence on prognosis after TBI.
title: "Nouvelle composition pharmaceutique utile pour le traitement des personnes atteintes du Virus de l’Immunodéficience Humaine (VIH)" : projet de brevet
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-2019311113333785
description: created: start=1975;end=2018
Generating triangle meshes by combining edge splitting, edge swapping, and angle-based smoothing
Creators: name: Johnson, Samuel
name: Renka, Robert
Publisher: name: figshare
Year: 2016
Subjects: subject: Computer Engineering
subject: Applied Computer Science
subject: 80103 Computer Graphics
subject: FOS: Computer and information sciences
subject: Computer Software

description: The Matlab implementation of the methods and the meshes used to test them described in the paper "Generating triangle meshes by combining edge splitting, edge swapping, and angle-based smoothing."
WATERSPY FOR DRINKING WATER MICROBIAL DETECTION: A SHIELD TOWARDS VASCULAR DISEASE
Creators: name: Angeli, Aikaterini
name: Doulamis, Nikolaos
Publisher: name: Zenodo
Year: 2018
Subjects: photonic, water quality, microbial detection

description: This work is a brief presentation of the WaterSpy project, it's main objectives and the challenges that all partners faced during the development of the WaterSpy system. The poster also contains a short analysis of the system's core, along with it's individual components. Emphasis is placed on the positive effect of the WaterSpy system towards the microbial detection in drinking water.
Genetic Stock Structure of Anadromous Arctic Char in Canada’s Central Arctic: Potential Implications for the Management of Canada’s Largest Arctic Char Commercial Fishery
Creators: name: Harris, Les N.
name: Jean-Sébastien Moore
name: Bajno, Robert
name: Tallman, Ross F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: The Arctic Char Salvelinus alpinus is widely considered the most important subsistence fish species in the Canadian Arctic. Throughout the species’ range, commercial fisheries for Arctic Char also exist, the management of which primarily follows river-specific harvest strategies. Such an approach, however, may not be appropriate if the management unit or stock does not accurately reflect a demographically independent population or if mixtures of populations are being harvested. We assayed microsatellite DNA variation among 744 Arctic Char from the Cambridge Bay region, Nunavut, where the largest commercial fishery for the species exists, in order to identify the most appropriate spatial scale at which these stocks should be managed. Our sampling design specifically mirrored that of the commercial fishery in order to describe patterns of genetic structure and genetic variation within and among the harvested component. We also included Arctic Char from more geographically distant sampling locations to provide a spatial context for genetic stock structuring in the region. Overall, we found moderate but significant structure across the entire study area. In contrast, commercially harvested stocks were weakly differentiated, especially among the stocks that are considered part of the Wellington Bay complex. We propose several hypotheses for this weak differentiation, including (1) our sampling design that mirrored the commercial harvest, (2) high rates of potential gene flow, and (3) large effective population sizes. Our results may have important implications for commercial and subsistence fisheries management, including the notion that there are several potential units of conservation below the species level. Received September 29, 2015; accepted August 17, 2016 Published online November 28, 2016
Links between self-injury and suicidality in autism.
Creators: name: Moseley, R L
name: Gregory, N J
name: Smith, P
name: Allison, C
name: Baron-Cohen, S
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Autism
Self-injury
Suicidality

description: BACKGROUND:Autistic individuals without intellectual disability are at heightened risk of self-injury, and appear to engage in it for similar reasons as non-autistic people. A wide divergence of autistic perspectives on self-injury, including those who frame it as a helpful coping mechanism, motivate investigating the link between self-injury, suicide ideation, and attempts which has been reported in typically developing individuals. METHOD:One hundred three autistic participants completed the Non-Suicidal Self-Injury Assessment Tool (NSSI-AT), the Suicide Behaviors Questionnaire (SBQ-R), and the Interpersonal Social Evaluation List (ISEL-12) across two online studies. Logistic regression was conducted to predict self-harming status via responses to questions on suicidality, and to predict whether certain self-injurious behaviors, including cutting, were especially associated with suicide ideation and attempts. Non-parametric correlation analysis examined relationships between suicide ideation/attempts and other variables that might characterize self-harmers especially at risk of suicidality. These included perceived access to social support, purposes or reasons for self-injury, the number of different self-injurious behaviors engaged in, the duration and lifetime incidence of self-injury, and the individual's feelings about their self-injury. RESULTS:While self-injuring status was significantly predicted by responses to a question on suicide ideation and attempts, there was no relationship between suicide ideation/attempts and a participant's personal feelings about their self-injury. The method of cutting was also predicted by suicide ideation and attempts, though other methods common in autistic people were at borderline significance. Use of self-injury for the regulation of low-energy emotional states like depression, for self-punishment or deterrence from suicide, and for sensory stimulation, was associated with suicide ideation and attempts, as was the number of self-injurious behaviors engaged in. There was no significant relationship between suicide ideation/attempts and the duration and lifetime incidence of self-injury or social support. CONCLUSIONS:These preliminary data suggest that while individuals might frame their self-injury as a positive or neutral thing, there remains a concerning relationship between self-injury and suicidality which exists regardless of individual feelings on self-injury. This is consistent with the theoretical perspective that self-injury can be a "gateway" through which individuals acquire capability for lethal suicidal behaviors. The data highlight that particular methods (cutting) and reasons for self-injury may be of significant concern, but this information, which might be of extreme value for clinicians, requires further investigation and validation.
Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.
Creators: name: Fermont, Jilles M
name: Bolton, Charlotte E
name: Fisk, Marie
name: Mohan, Divya
name: Macnee, William
name: Cockcroft, John R
name: McEniery, Carmel
name: Fuld, Jonathan
name: Cheriyan, Joseph
name: Tal-Singer, Ruth
name: Wilkinson, Ian B
name: Wood, Angela M
name: Polkey, Michael I
name: Müllerova, Hana
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The ERICA study assessed multiple clinical measures in people with COPD, including the short physical performance battery (SPPB), a simple test of physical function with 3 components (gait speed, balance and sit-to-stand). We tested the hypothesis that SPPB score would relate to risk of hospital admissions and length of hospital stay. Data were analysed from 714 of the total 729 participants (434 men and 280 women) with COPD. Data from this prospective observational longitudinal study were obtained from 4 secondary and 1 tertiary centres from England, Scotland, and Wales. The main outcome measures were to estimate the risk of hospitalisation with acute exacerbation of COPD (AECOPD and length of hospital stay derived from hospital episode statistics (HES). In total, 291 of 714 individuals experienced 762 hospitalised AECOPD during five-year follow up. Poorer performance of SPPB was associated with both higher rate (IRR 1.08 per 1 point decrease, 95% CI 1.01 to 1.14) and increased length of stay (IRR 1.18 per 1 point decrease, 95% CI 1.10 to 1.27) for hospitalised AECOPD. For the individual sit-to-stand component of the SPPB, the association was even stronger (IRR 1.14, 95% CI 1.02 to 1.26 for rate and IRR 1.32, 95% CI 1.16 to 1.49 for length of stay for hospitalised AECOPD). The SPPB, and in particular the sit-to-stand component can both evaluate the risk of H-AECOPD and length of hospital stay in COPD. The SPPB can aid in clinical decision making and when prioritising healthcare resources.
Drought Stress Causes Specific Changes to the Spliceosome and Stress Granule Components.
Creators: name: Marondedze, Claudius
name: Thomas, Ludivine
name: Lilley, Kathryn S
name: Gehring, Chris
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Drought stress
Systems analysis
RNA-binding proteins
Spliceosome
Stress Granules
Mrna Interactome Capture

description: The spliceosome processes RNAs from a pre-RNA state to a mature mRNA thereby influencing RNA availability for translation, localization, and turnover. It consists of complex structures containing RNA-binding proteins (RBPs) essential for post-transcriptional gene expression control. Here we investigate the dynamic modifications of spliceosomal RBPs under stress and in particular drought stress. We do so by mRNA interactome capture in Arabidopsis thaliana using label free quantitation. This approach identified 44 proteins associated with the spliceosome and further 32 proteins associated with stress granules. We noted a high enrichment in the motifs RDRR and RSRSRS that are characteristic of RNA interacting proteins. Identification of splicing factors reflect direct and/or indirect stress induced splicing events that have a direct effect on transcriptome and proteome changes under stress. Furthermore, detection of stress granule components is consistent with transcriptional arrest. Identification of drought induced stress granule components is critical in determining common abiotic stress-induced foci that can have biotechnological applications. This study may therefore open ways to modify plant stress responses at a systems level through the modification of key spliceosome components.
Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier.
Creators: name: Tjakra, Marco
name: Wang, Yeqi
name: Vania, Vicki
name: Hou, Zhengjun
name: Durkan, Colm
name: Wang, Nan
name: Wang, Guixue
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Blood brain barrier
Cytokines
Developmental
Mechanical stress
miRNA
Tight junctions
Physicochemical
transcytosis

description: Blood brain barrier (BBB) conserves unique regulatory system to maintain barrier tightness while allowing adequate transport between neurovascular units. This mechanism possess a challenge for drug delivery, while abnormality may result in pathogenesis. Communication between vascular and neural system is mediated through paracellular and transcellular (transcytosis) pathway. Transcytosis itself showed dependency with various components, focusing on caveolae-mediated. Among several factors, intense communication between endothelial cells, pericytes, and astrocytes is the key for a normal development. Regulatory signaling pathway such as VEGF, Notch, S1P, PDGFβ, Ang/Tie, and TGF-β showed interaction with the transcytosis steps. Recent discoveries showed exploration of various factors which has been proven to interact with one of the process of transcytosis, either endocytosis, endosomal rearrangement, or exocytosis. As well as providing a hypothetical regulatory pathway between each factors, specifically miRNA, mechanical stress, various cytokines, physicochemical, basement membrane and junctions remodeling, and crosstalk between developmental regulatory pathways. Finally, various hypotheses and probable crosstalk between each factors will be expressed, to point out relevant research application (Drug therapy design and BBB-on-a-chip) and unexplored terrain.
Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion.
Creators: name: Cortese, Andrea
name: Tozza, Stefano
name: Yau, Wai Yan
name: Rossi, Salvatore
name: Beecroft, Sarah J
name: Jaunmuktane, Zane
name: Dyer, Zoe
name: Ravenscroft, Gianina
name: Lamont, Phillipa J
name: Mossman, Stuart
name: Chancellor, Andrew
name: Maisonobe, Thierry
name: Pereon, Yann
name: Cauquil, Cecile
name: Colnaghi, Silvia
name: Mallucci, Giulia
name: Curro, Riccardo
name: Tomaselli, Pedro J
name: Thomas-Black, Gilbert
name: Sullivan, Roisin
name: Efthymiou, Stephanie
name: Rossor, Alexander M
name: Laurá, Matilde
name: Pipis, Menelaos
name: Horga, Alejandro
name: Polke, James
name: Kaski, Diego
name: Horvath, Rita
name: Chinnery, Patrick F
name: Marques, Wilson
name: Tassorelli, Cristina
name: Devigili, Grazia
name: Leonardis, Lea
name: Wood, Nick W
name: Bronstein, Adolfo
name: Giunti, Paola
name: Züchner, Stephan
name: Stojkovic, Tanya
name: Laing, Nigel
name: Roxburgh, Richard H
name: Houlden, Henry
name: Reilly, Mary M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Chronic Cough
Sensory Neuropathy
Rfc1
Repeat Expansion
Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (Canvas)

description: Ataxia, causing imbalance, dizziness and falls, is a leading cause of neurological disability. We have recently identified a biallelic intronic AAGGG repeat expansion in replication factor complex subunit 1 (RFC1) as the cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) and a major cause of late onset ataxia. Here we describe the full spectrum of the disease phenotype in our first 100 genetically confirmed carriers of biallelic repeat expansions in RFC1 and identify the sensory neuropathy as a common feature in all cases to date. All patients were Caucasian and half were sporadic. Patients typically reported progressive unsteadiness starting in the sixth decade. A dry spasmodic cough was also frequently associated and often preceded by decades the onset of walking difficulty. Sensory symptoms, oscillopsia, dysautonomia and dysarthria were also variably associated. The disease seems to follow a pattern of spatial progression from the early involvement of sensory neurons, to the later appearance of vestibular and cerebellar dysfunction. Half of the patients needed walking aids after 10 years of disease duration and a quarter were wheelchair dependent after 15 years. Overall, two-thirds of cases had full CANVAS. Sensory neuropathy was the only manifestation in 15 patients. Sixteen patients additionally showed cerebellar involvement, and six showed vestibular involvement. The disease is very likely to be underdiagnosed. Repeat expansion in RFC1 should be considered in all cases of sensory ataxic neuropathy, particularly, but not only, if cerebellar dysfunction, vestibular involvement and cough coexist.
Understanding particles emitted from spray and wall-guided gasoline direct injection and flex fuel vehicles operating on ethanol and iso-butanol gasoline blends
Creators: name: Short, Daniel
name: Vu, Diep
name: Chen, Vincent
name: Espinoza, Carlos
name: Berte, Tyler
name: Karavalakis, Georgios
name: Durbin, Thomas D.
name: Akua Asa-Awuku
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Traffic-related pollutants are an ever-growing concern. However, the composition of particle emissions from new vehicle technologies using relevant current and prospective fuel blends is not known. This study tested four current and up-and-coming vehicle technologies with nine fuel blends with various concentrations of ethanol and iso-butanol. Vehicles were driven on both the federal test procedure (FTP) and the unified cycle (UC). Additional tests were conducted under steady-state speed conditions. The vehicle technologies include spray-guided gasoline direct injection (SG-GDI), wall-guided gasoline direct injection (WG-GDI), port-fuel injection flex fuel vehicle (PFI-FFV), and a wall-guided GDI-FFV. The fuels consisted of 10–83% ethanol and 16–55% iso-butanol in gasoline. The composition of soot, water-insoluble mass (WIM), water-soluble organic mass, and water-insoluble organic mass (WIOM), and OM was measured. The majority of emissions over FTP and UC were water-insoluble (>70%), and WIOM contributes mostly to OM. PFIs have lower soot and particulate matter (PM) emissions in comparison to the WG-GDI technology even while increasing the renewable fuel content. SG-GDI technology, which has not penetrated the market, show promise as soot and PM emissions are comparable to PFI vehicles while preserving the GDI fuel economy benefits. The WIM fraction in GDI-FFV consistently increased with increasing ethanol concentration. Lastly, the impact of the future vehicle emissions and traffic pollutants is discussed. SG-GDI technology is found to be a promising sustainable technology to enhance fuel economy and also reduce PM, soot, and WIM emissions. Copyright © 2017 American Association for Aerosol Research
Ozone-free post-DBD aerosol bipolar diffusion charger: Evaluation as neutralizer for SMPS size distribution measurements
Creators: name: Mathon, Rémi
name: Jidenko, Nicolas
name: Jean-Pascal Borra
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: A postplasma neutralizer for submicron particles size measurements by mobility analysis has been evaluated. Bipolar ion currents have been measured downstream a dielectric barrier discharge (DBD) to estimate the ion fluxes at the inlet of charging volume and the ni·τ product that define the theoretical maximal concentration that can be neutralized. Charge distributions were measured versus DBD voltage, aerosol diameter and concentration for monodisperse aerosols. It is confirmed that the charge distribution of particles depends on the ratio of initial positive and negative ion currents controlled by the DBD voltage leading to a tuneable mean charge of aerosol in this post-DBD bipolar charger. As expected from Gunn's law, the mean charge and the variance are proportional to particle diameter above 50 nm and independent of the aerosol concentration. The size distributions measured with 85Kr and post-DBD neutralizer present the same modal diameters and a maximal overestimation of the total concentration of 10%, for aerosol from 15 to 730 nm with concentrations up to 6 × 1012 m−3. This post-DBD bipolar charger can be used for submicron aerosol neutralization and thus for scanning mobility particle sizer size distribution measurements in air as well as in nitrogen to suppress ozone downstream DBD. Copyright © 2017 American Association for Aerosol Research
Data & Code from TinHan et al. 2020 "Natural tags identify nursery origin of a coastal elasmobranch (Carcharhinus leucas)"
Creators: name: O'Leary, Shannon J
name: TinHand, Thomas C.
Publisher: name: Zenodo
Year: 2020

description: Data and scripts underlying analysis for "Natural tags identify nursery origin of a coastal elasmobranch (Carcharhinus leucas)" (2020), TinHan TC, O'Leary SJ, Portnoy DS, Rooker JR, Gelpi CG, Wells RJD
Understanding Particles emitted from Spray and Wall-Guided Gasoline Direct Injection and Flex Fuel Vehicles Operating on Ethanol and Iso-butanol Gasoline Blends
Creators: name: Short, Daniel
name: Vu, Diep
name: Chen, Vincent
name: Espinosa, Carlos
name: Berte, Tyler
name: Karavalakis, Georgios
name: Durbin, Thomas D.
name: Akua Asa-Awuku
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Traffic related pollutants are an ever-growing concern. However the composition of particle emissions from new vehicle technologies using relevant current and potential fuel blends is not known. This study tested four current and up-and-coming vehicle technologies with 9 current and prospective fuel blends with various concentrations of ethanol and iso-butanol. Vehicles were driven over both the Federal Test Procedure (FTP) and Unified Cycle (UC). Additional tests were conducted under steady-state speed conditions. The vehicle technologies include Spray Guided- Gasoline Direct Injection (SG-GDI), Wall Guided – Gasoline Direct Injection (WG-GDI), Port Fuel Injection Flex Fuel Vehicle (PFI- FFV), and a wall guided GDI-FFV. The fuels consisted of 10% to 83% ethanol and 16% to 55% iso-butanol in gasoline. The composition of soot, water-insoluble mass (WIM), water-soluble organic mass(WSOM) and water- insoluble organic mass(WIOM), and organic mass(OM) were measured. Briefly, the majority of emissions over FTP and UC were water insoluble (>70%) and WIOM contributes mostly to the OM. PFIs have lower soot and PM emissions in comparison with the wall-guided GDI technology; even while increasing the renewable fuel content. Spray-guided GDI technologies, which have not penetrated the market, show promise, as soot and PM emissions are comparable to PFI vehicles while preserving the GDI fuel economy benefits. The WIM fraction in GDI-FFV consistently increased with increasing ethanol concentration. Lastly, the impact for future vehicle emissions and traffic pollutants is discussed. SG-GDI technology is found to be a promising sustainable technology to enhance fuel economy and also reduce PM, soot and WIM emissions.
The effects of drug and alcohol consumption on driver-injury severities in single-vehicle crashes
Creators: name: Behnood, Ali
name: Mannering, Fred L.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: It is well known that alcohol and drugs influence driving behavior by affecting the central nervous system, awareness, vision, and perception/reaction times, but the resulting effect driver-injuries in car crashes is not fully understood. The purpose of this study was to identify factors affecting the injury severities of unimpaired, alcohol-impaired and drug-impaired drivers Method: The current paper applies a random parameters logit model to study the differences in injury severities among unimpaired, alcohol-impaired and drug-impaired drivers. Using data from single-vehicle crashes in Cook County Illinois over a nine-year period from January 1, 2004 to December 31, 2012, separate models for unimpaired, alcohol-impaired and drug-impaired drivers were estimated. A wide range of variables potentially affecting driver-injury severity was considered including roadway and environmental conditions, driver attributes, time and location of the crash, and crash-specific factors. Results: The estimation results show significant differences in the determinants of driver injury severities across groups of unimpaired, alcohol-impaired and drug-impaired drivers. The findings also show that unimpaired drivers are understandably more responsive to variations in lighting, adverse weather and road conditions, but these drivers also tend to have much more heterogeneity in their behavioral responses to these conditions, relative to impaired drivers. In addition, age and gender were found to be important determinants of injury severity, but the effects varied significantly across all drivers, particularly among alcohol-impaired drivers. Conclusions: The model estimation results show that statistically significant differences exist in driver-injury severities among the unimpaired, alcohol-impaired, and drug-impaired driver groups considered. Specifically, we find that unimpaired drivers tend to have more heterogeneity in their injury outcomes in the presence potentially adverse weather and road-surface conditions. This makes sense because one would expect unimpaired drivers to apply their full knowledge/judgment range to deal with these conditions, and the variability of this range across the driver population (with different driving experiences, etc.) should be great. In contrast we find, for the most part, that alcohol-impaired and drug-impaired drivers have far less heterogeneity in the factors that affect injury severity, suggesting an equalizing effect resulting from the decision-impairing substance.
MyGene2 automated match report: GUCY1A3
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for GUCY1A3.
MyGene2 automated match report: USP7
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for USP7.
MyGene2 automated match report: NALCN
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for NALCN.
MyGene2 automated match report: ACTC1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for ACTC1.
MyGene2 automated match report: LARS
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for LARS.
MyGene2 automated match report: MECP2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for MECP2.
MyGene2 automated match report: TPM2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for TPM2.
MyGene2 automated match report: SETBP1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for SETBP1.
MyGene2 automated match report: TAF4
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for TAF4.
MyGene2 automated match report: SATB2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for SATB2.
MyGene2 automated match report: SLC52A2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for SLC52A2.
MyGene2 automated match report: PIEZO2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for PIEZO2.
title: Digitale Medienkompetenzen in erwachsenenpädagogischen Kursangeboten
title: Eine exemplarische Programmanalyse der Volkshochschule Berlin Mitte
titleType: Subtitle
Creators: name: Jokuszies, Regina
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: Volkshochschule
subject: Erwachsenenbildung
subject: Digitalisierung
subject: DigComp-Modell
subject: 374 Erwachsenenbildung

description: Die vorliegende Masterarbeit untersucht, wie die Volkshochschule als größte Institution der Erwachsenenbildung in Deutschland – hier exemplarisch die VHS Berlin Mitte – die Digitalisierung in ihrem Programm thematisiert. Die Arbeit geht der Frage nach, welche digitalen Medienkompetenzen aufgegriffen werden, welche aktuellen gesellschaftlichen Anforderungen einer digitalisierten Welt im Programm aufgenommen sind und welche Problemlagen sich darin spiegeln. Mit ihrem öffentlichen Auftrag Lernende zu gesellschaftlicher Teilhabe zu verhelfen, versucht die Volkshochschule aktuelle gesellschaftliche Bedarfe hinsichtlich digitaler Umbrüche als Thema aufzunehmen und in Kursangebote zu übersetzen. Folglich schlagen sich antizipierte Bedarfe in den Programmen und institutionellen Zielen nieder. Planende der Volkshochschule müssen den Spagat zwischen abstrakten Diskursen und konkreten Bedürfnissen gestalten, um Transformationsprozesse der Digitalisierung adäquat zu begleiten. Das Interesse der Arbeit gilt daher der konkreten Übersetzung von Bildungsangeboten. Insbesondere der Begriff der Digitalisierung als Containerwort, der von der ein-fachen Anwendung digitaler Medien bis hin zur gesellschaftlichen Transformation viel-schichtige Bedeutungen haben kann, hebt die Relevanz der konkreten Übersetzung her-vor. Die Erwachsenenbildung als Modellierungsinstanz ist gefordert sich mit den Auswirkungen und entstandenen Herausforderungen der Digitalisierung auseinanderzusetzen, die sich in Lebens- und Arbeitswelt äußern – beispielsweise in den Punkten Demokratie und Mündigkeit sowie auch in der Gefahr einer gesellschaftlichen, digitalen Spaltung ‚digital divide‘. Um den Herausforderungen in den verschiedenen Lebenswelten adäquat zu begegnen, werden digitale Medienkompetenzen benötigt. Dementsprechend ist eine allgemeine digitale Medienkompetenz von Bürger:innen erstrebenswert, welche nicht nur auf anwendungsbezogenes Wissen abzielt, sondern vielmehr auf einer kritisch reflexiven Ebene gesellschaftliche Auswirkungen der Digitalisierung beinhaltet. Das Medienkompetenzmodell von Dieter Baacke gilt bis heute als weiterführend und wird dieser Arbeit zugrunde gelegt. Ergänzt wird dies um das 20 Jahre jüngere und weniger theoretisch rückgebundene DigComp-Modell, was als Referenzrahmen für die Gestaltung konkreter Bildungsangebote gilt und zur Analyse der Arbeit eine heuristische Hilfe darstellt. Mittels einer exemplarischen Programmanalyse wird in dieser Arbeit das Gesamtprogramm einer Volkshochschule untersucht. Die Analyse fokussiert sich auf Angebote, in denen ausschließlich digitale Medienkompetenzen als Kursinhalte aufgenommen sind.
MyGene2 automated match report: MYLK
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for MYLK.
MyGene2 automated match report: B3GAT2
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for B3GAT2.
Additional file 1 of Practitioner perspectives on building capacity for evidence-based public health in state health departments in the United States: a qualitative case study
Creators: name: Mazzucca, Stephanie
name: Valko, Cheryl A.
name: Eyler, Amy A.
name: Macchi, Marti
name: Lau, Andrew
name: Alongi, Jeanne
name: Robitscher, John
name: Brownson, Ross C.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Interview guide
title: 02_0649
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/