cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rare genetic variants explain missing heritability in smoking
Creators: name: Telen, M.J.
name: Wang, Z.
name: Jenkins, B.W.C.
name: Kelly, S.
name: Gordeuk, V.R.
name: Qiao, D.
name: Hwang, S.-J.
name: Damrauer, S.M.
name: Heckbert, S.R.
name: Garrett, M.E.
name: Custer, B.
name: Justice, A.E.
name: Redline, S.
name: Rotter, J.I.
name: Yang, I.V.
name: Levy, D.
name: Peljto, A.L.
name: Keller, M.C.
name: Zhang, Y.
name: Manichaikul, A.W.
name: Meyers, D.A.
name: Fialkowski, A.
name: Reed, R.M.
name: Haessler, J.
name: Kardia, S.L.R.
name: Oelsner, E.C.
name: Judy, R.
name: Kooperberg, C.
name: North, K.E.
name: Smith, J.A.
name: Evans, L.
name: Psaty, B.M.
name: Hou, L.
name: Bis, J.C.
name: Rafaels, N.
name: Liu, D.J.
name: Yanek, L.R.
name: Silverman, E.K.
name: Payton, M.
name: Smith, N.L.
name: Young, K.L.
name: David, S.P.
name: Cade, B.E.
name: Fornage, M.
name: Brody, J.A.
name: Preuss, M.
name: Kim, W.
name: Peyser, P.A.
name: Martin, L.W.
name: Becker, D.M.
name: Barnes, K.C.
name: Wiggins, K.L.
name: Rich, S.S.
name: Loos, R.J.F.
name: Cupples, L.A.
name: Smith, A.V.
name: Lloyd-Jones, D.M.
name: Palmer, N.D.
name: Smith, J.G.
name: Young, K.A.
name: Vasan, R.S.
name: Freedman, B.I.
name: Jang, S.-K.
name: Fingerlin, T.E.
name: Boorgula, M.P.
name: Glahn, D.C.
name: Gharib, S.A.
name: Ashley-Koch, A.E.
name: Montgomery, C.G.
name: Chavan, S.
name: Taylor, K.D.
name: Reiner, A.P.
name: Tang, W.
name: Rader, D.J.
name: Hokanson, J.E.
name: Hyman, M.C.
name: Arnett, D.K.
name: Schwartz, D.A.
name: Kaplan, R.C.
name: Bowden, D.W.
name: Shadyab, A.H.
name: Bleecker, E.R.
name: Melander, O.
name: Vrieze, S.
name: Blangero, J.
name: Nouraie, M.
name: de Andrade, M.
name: Carson, A.P.
name: Dinardo, C.L.
name: Gladwin, M.T.
Publisher: name: Nature Research
Year: 2022

description: Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this ‘missing heritability’. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability (hSNP2) was estimated from 0.13 to 0.28 (s.e., 0.10–0.13) in European ancestries, with 35–74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5–4 times higher than past estimates based on common variants alone and accounted for 60% to 100% of our pedigree-based estimates of narrow-sense heritability (hped2, 0.18–0.34). In the African ancestry samples, hSNP2 was estimated from 0.03 to 0.33 (s.e., 0.09–0.14) across the four smoking traits. These results suggest that rare variants are important contributors to the heritability of smoking.
Fold-back: Using emerging technologies to move from quality assurance to quality enhancement
Creators: name: Leonard, Simon N.
name: Fitzgerald, Robert N.
name: Bacon, Matt
Publisher: name: figshare
Year: 2014
Subjects: Design
Education

description: A draft paper arguing for more nuanced approaches to feedback in education. In this paper we develop the idea of 'foldback' to suggest that feedback should be from a variety of information sources, and well mixed to support the specific user. We develop a matrix of analysis that may assist in this, and discuss how emerging technologies may support a foldback approach.
ПАЛЕОПЕДОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ МНОГОСЛОЙНОГО ПОСЕЛЕНИЯ КОЩЕЕВКА-8
Creators: name: Матвиишина Жанна Николаевна
name: Лысенко Сергей Дмитриевич
name: Пархоменко Александр Григорьевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Среднее Поднепровье
эпоха бронзы
тшинекий культурный круг
комаровская культура
палеопочвы
суббореал

description: Статья посвящена анализу палеопочв многослойного поселения Кощеевка-8, расположенного в Фастовском районе Киевской области (позднее триполье, эпоха бронзы, древнерусский период). За исторический период ландшафты данной территории не могли сильно измениться. Вероятно, что и в эпоху бронзы, как и в древнерусское время была развита обширная пойма (до 100 м шириной) р. Унавы, сформированы аллювиальные песчаные отложения I—II надпойменных террас. Песчаные и супесчаные отложения явились предпосылкой для формирования дёрновых почв под травянистой (а не лесной) растительностью, но профили почв были короче современных. Интенсивная фаунистическая активность является дополнительным свидетельством того, что условия были благоприятными для занятия сельским хозяйством, водно-физические свойства почв улучшились благодаря их окультуриванию. Вероятно, как и сейчас, существовали открытые пространства, пригодные для сельскохозяйственного использования благодаря лёгкости их обработки. Мощные профили торфяно-болотных почв на поймах свидетельствуют о том, что они не могли сформироваться в короткое время и население древнего поселения могло использовать участки лугов на поймах для выпаса скота, а реку — для отлова рыбы. Человек выбирал место поселения ближе к водной артерии и с максимальным разнообразием ландшафтов, именно таким местом и является описываемая территория у с. Кощеевка.
ПЕКТОРАЛИ ИРАНСКИХ И ИРАНИЗИРОВАННЫХ НАРОДОВ ДРЕВНОСТИ
Creators: name: Яценко Сергей Александрович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: пекторали
древний иранский мир
этапы распространения
специфика использования в регионах
ритуальные и социальные функции
гендерные различия
обряды с пекторалями.

description: Пекторали иранского мира VII в. до н.э. — VII в. н.э. — очень редкие аксессуары костюма, обычно делавшиеся из золота. Многие из них не имели декора. Они почти не представлены в изобразительном искусстве и не упоминаются в письменных источниках. Ритуальная ценность пекторалей демонстрируется обрядами с ними и их хозяевами (помещение их отдельно от умершего, как бы нависая над ним; удаление всех нижних подвесок; нахождение могил с ним на краю некрополя и др.). Имеются различия в сюжетах между женщинами (1—2 ряда копытных) и мужчинами (терзание крупных животных или сражение, две симметричных пары—тройки мужчин). Исходный импульс был в бронзовом веке с северо-запада Китая и с VII в до н.э. из Тувы, во второй половине VI в. до н.э. они появляются в империи Ахеменидов, с середины V в. до н.э. в Скифии. На западе на них повлияли особенности пекторалей Урарту. У разных народов их назначение было, вероятно, разным (в Туве — как символы доминирующих кланов, в Иране — как царские дары чиновникам, в Скифии — как сакральные атрибуты с изображением модели мироздания). Последним районом их использования еще недавно был Восточный Гиндукуш, где пуштуны и дарды сохранили в декоре пекторалей часть традиций древних иранцев
ТРЕТЬЯ СЕРИЯ ЗЕРКАЛ БОРИСФЕНИТСКОГО ТИПА (К ВОПРОСУ О КЛАССИФИКАЦИИ МАССОВОГО АРХЕОЛОГИЧЕСКОГО МАТЕРИАЛА ЭПОХИ АРХАИКИ)
Creators: name: Зуев Вадим Юрьевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: археология
история
Скифия
архаика
бронзовые зеркала борисфенитского типа
ионийское художественное литье
классификация массового археологического материала

description: Вводится в научный оборот шестьдесят шесть экз. зеркал и их фрагментов из самой массовой — третьей серии зеркал борисфенитского типа. Они изготовлялись в одном производственном центре — в металлургической мастерской г. Борисфен на острове Березань, работавшей с середины по конец VI в. до н.э. Зеркала делятся по морфологическим признакам на четыре варианта. Они отличаются деталями оформления. Все они изготавливали методом литья по утрачиваемой восковой модели с последующей сборкой фрагментов (диск, рукояти, фигурок пантер на цапфах для насада) в цельный экземпляр. Приводится каталог этих артефактов. Он содержит исчерпывающую информацию обо всех артефактах этой серии, в т.ч. сведения о географической локализации их находок от Южного Приуралья и Северного Кавказа на востоке до Трансильвании на западе, включая все Северное Причерноморье.
О КОЛЧАННЫХ НАБОРАХ СКИФОВ ПЕРВОЙ ПОЛОВИНЫ — СЕРЕДИНЫ V В. ДО Н.Э. (БАШНЕВИДНЫЙ ГОРИЗОНТ)
Creators: name: Дараган Марина Николаевна
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Северное Причерноморье
скифы
хронология
наконечники стрел
производство
снабжение.

description: На примере башневидных скифских наконечников стрел проведен поиск в различных колчанах из курганов Северного Причерноморья серий идентичных и однотипных наконечников, отлитых в одной форме или в однотипных формах. Выделена серия погребений с идентичными однотипными башневидными наконечниками стрел с ложком до острия, с П-образным ложком на ⅔ высоты головки с выступающей втулкой и аналогичных им по строению головки наконечниками со скрытой втулкой размерами 2—3,5 см. Весом 1,4—2,7 г. Воины, в погребениях которых найдены такие наконечники, были современниками. Время использования наконечников стрел из этих погребений по их отложению в погребальных комплексах ограничено первой четвертью V — не позже третьей четверти V в. до н.э. Изученные группы башневидных наконечников стрел являются исключительно северопричерноморским продуктом. Башневидные стрелы этого временного среза отличны от стрел как предшествующих базисного горизонта (второй половины VI — начала V в. до н.э.), так и сменяющих их стрел, образующих горизонт «крестовидных меток», датирующийся с третьей четверти V в. до н.э. Появление серий идентичных в техническом и стилистическом отношениях наконечников на сравнительно большой территории свидетельствует не только об изготовлении их в одной среде, но и о существовании ремесленных производств, работавших на рынок. В источнике снабжения можно видеть одного мастера или одну мастерскую или же несколько мастерских, но работавших по единым шаблонам.
Fold-back: Using technology assisted developmental evaluation to chart value in education
Creators: name: Leonard, Simon N.
name: Fitzgerald, Robert N.
name: Bacon, Matt
Publisher: name: figshare
Year: 2014
Subjects: Design
Education

description: A draft paper arguing for more nuanced approaches to feedback in education. In this paper we develop the idea of 'foldback' to suggest that feedback should be from a variety of information sources, and well mixed to support the specific user. We discuss emerging technologies that may support this.
БЕНДЕРСКАЯ КРЕПОСТЬ В XVI В. ПО ДАННЫМ АРХЕОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ
Creators: name: Разумов Сергей Николаевич
name: Фидельский Сергей Анатольевич
name: Четвериков Игорь Анатольевич
name: Симоненко Сергей Олегович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Нижнее Поднестровье
XVI в.
Бендерская крепость
Османская империя
фортификация
Молдавское княжество
археология
архитектура

description: В феврале—марте 2019 г. Днестровская археологическая экспедиция провела исследования нижнего яруса Юго-Восточной башни цитадели Бендерской крепости. На глубине 3,35 м от уровня входа расчищен пол из каменной крошки с известью. Его сооружение связано с первым стратиграфическим горизонтом башни (1538 г.). Второй горизонт представлен заполнением нижнего яруса башни в виде светло-жёлтого лессовидного суглинка, мощностью 1,6—1,7 м, в котором были найдены фрагменты гончарной керамики XVI в., металлические изделия и кости животных. Археологические исследования 2019 г. подтвердили версию о том, что первые каменные укрепления были сооружены здесь именно турками, и не ранее конца 1530-х гг. В ходе исследований второго стратиграфического горизонта установлено, что он сформировался в процессе реконструкции и расширения крепости в 1584 г. В начале этого года по приказу турецкого султана молдавский господарь Пётр Хромой приступил к реконструкции полуразрушенных польско-казацкими набегами укреплений. За несколько месяцев были сооружены внутренний ров и Нижняя крепость. Суглинок из заполнения рва был использован для засыпки нижнего яруса Юго-Восточной, и вероятно, других башен цитадели, чтобы укрепить их против усилившейся осадной артиллерии и подкопов. В материалах этого горизонта отразились новые тенденции в фортификационном искусстве второй половины XVI в. на территории Северного Причерноморья и соседних регионов.
ЮЛИАН АПОСТАТ. ПЕРСИДСКИЙ ПОХОД И ЗАГАДКА БИТВЫ У ТУММАРА 26 ИЮНЯ 363 Г.
Creators: name: Вус Олег Владимирович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Юлиан Апостат
стратегическая наступательная операция
Персидский поход
Месопотамия
Маранга
битва при Туммаре

description: В статье на основе изучения и анализа нарративных источников исследуется завершающий этап Римско-Иранской войны 338—363 гг. Главной составляющей этого этапа стала стратегическая наступательная операция (Персидский поход), разработанная и проведенная императором Юлианом Апостатом. В исследовании освещается военно-дипломатическая, организационная и боевая деятельность Юлиана при подготовке и в ходе операции; проведен пошаговый анализ боевых столкновений в Месопотамии с апреля по июль 363 г. Подвергнуты корректировке вопросы хронологии и топографии сражений, и определен пик боевого напряжения, наступивший 25—26 июня 363 г. в битвах у Маранги и Туммара. Выдвинута гипотеза о ранении Юлиана в схватке с воином-арабом племени Бану Тайи, и причине смерти императора, наступившей в полночь 29 июня 363 г. Автор констатирует, что из-за гибели командующего и потери управления, стратегическая наступательная операция римлян против Ирана своих целей не достигла, и завершилась полным военным и морально-психологическим разгромом; крупными людскими и территориальными потерями Римской империи в Месопотамии.
Fold-back: Using technology assisted developmental evaluation to chart value in education
Creators: name: Leonard, Simon N.
name: Fitzgerald, Robert N.
name: Bacon, Matt
Publisher: name: figshare
Year: 2015
Subjects: Design
Education

description: A draft paper arguing for more nuanced approaches to feedback in education. In this paper we develop the idea of 'foldback' to suggest that feedback should be from a variety of information sources, and well mixed to support the specific user. We discuss emerging technologies that may support this.
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
Creators: name: Lefort, Sylvain
name: Joffre, Carine
name: Kieffer, Yann
name: Givel, Anne-Marie
name: Bourachot, Brigitte
name: Zago, Giulia
name: Bieche, Ivan
name: Dubois, Thierry
name: Meseure, Didier
name: Vincent-Salomon, Anne
name: Camonis, Jacques
name: Mechta-Grigoriou, Fatima
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Astronomy, Astrophysics, Space Science
subject: Pharmacology
subject: Cell Biology
subject: Biochemistry

description: The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify autophagy as a key mechanism in the progression and chemoresistance of a subset of TN tumors. We demonstrate that LC3B, a protein involved in autophagosome formation, is a reliable marker of poor prognosis in TN BC, validating this prognostic value at both the mRNA and protein levels in several independent cohorts. We also show that LC3B has no prognostic value for other BC subtypes (Luminal or HER2 BC), thus revealing a specific impact of autophagy on TN tumors. Autophagy is essential for the proliferative and invasive properties in 3D of TN BC cells characterized by high LC3B levels. Interestingly, the activity of the transcriptional co-activator YAP1 (Yes-associated protein 1) is regulated by the autophagy process and we identify YAP1 as a new actor in the autophagy-dependent proliferative and invasive properties of high-LC3B TN BC. Finally, inhibiting autophagy by silencing ATG5 or ATG7 significantly impaired high-LC3B TN tumor growth in vivo. Moreover, using a patient-derived TN tumor transplanted into mice, we show that an autophagy inhibitor, chloroquine, potentiates the effects of chemotherapeutic agents. Overall, our data identify LC3B as a new prognostic marker for TN BC and the inhibition of autophagy as a promising therapeutic strategy for TN BC patients.
Dynamic relationships between body fat and circulating adipokine levels from adolescence to young adulthood: The Santiago Longitudinal Study
Creators: name: Santos, J.L.
name: Albala, C.
name: Gordon-Larsen, P.
name: Memili, A.
name: Blanco, E.
name: Gahagan, S.
name: Angel, B.
name: North, K.E.
name: Lozoff, B.
name: Correa-Burrows, P.
name: Burrows, R.
name: Kim, D.
name: Howard, A.G.
name: Justice, A.E.
Publisher: name: Elsevier B.V.
Year: 2022

description: Background and aims: Adipose tissue secretes adipokines such as adiponectin and leptin, playing important roles in energy metabolism. The longitudinal associations between such adipokines and body fat accumulation have not been established, especially during adolescence and young adulthood and in diverse populations. The study aims to assess the longitudinal association between body fat measured with dual X-ray absorptiometry and plasma adipokines from adolescence to young adulthood. Methods and results: Among Hispanic/Latino participants (N = 537) aged 16.8 (SD: 0.3) years of the Santiago Longitudinal Study, we implemented structural equation modeling to estimate the sex-specific associations between adiposity (body fat percent (BF%) and proportion of trunk fat (PTF)) and adipokines (adiponectin and leptin levels) during adolescence (16 y) and these values after 6 years of follow-up (22 y). In addition, we further investigated whether the associations differed by baseline insulin resistance (IR) status. We found evidence for associations between 16 y BF% and 22 y leptin levels (β (SE): 0.58 (0.06) for females; 0.53 (0.05) for males), between 16 y PTF and 22 y adiponectin levels (β (SE): −0.31 (0.06) for females; −0.18 (0.06) for males) and between 16 y adiponectin levels and 22 y BF% (β (SE): 0.12 (0.04) for both females and males). Conclusion: We observed dynamic relationships between adiposity and adipokines levels from late adolescence to young adulthood in a Hispanic/Latino population further demonstrating the importance of this period of the life course in the development of obesity.
Fold-back: Using emerging technologies to move from quality assurance to quality enhancement
Creators: name: Leonard, Simon N.
name: Fitzgerald, Robert N.
name: Bacon, Matt
Publisher: name: figshare
Year: 2015
Subjects: Design
Education

description: A draft paper arguing for more nuanced approaches to feedback in education. In this paper we develop the idea of 'foldback' to suggest that feedback should be from a variety of information sources, and well mixed to support the specific user. We develop a matrix of analysis that may assist in this, and discuss how emerging technologies may support a foldback approach.
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
Creators: name: Lefort, Sylvain
name: Joffre, Carine
name: Kieffer, Yann
name: Givel, Anne-Marie
name: Bourachot, Brigitte
name: Zago, Giulia
name: Bieche, Ivan
name: Dubois, Thierry
name: Meseure, Didier
name: Vincent-Salomon, Anne
name: Camonis, Jacques
name: Mechta-Grigoriou, Fatima
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Astronomy, Astrophysics, Space Science
subject: Pharmacology
subject: Cell Biology
subject: Biochemistry

description: The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify autophagy as a key mechanism in the progression and chemoresistance of a subset of TN tumors. We demonstrate that LC3B, a protein involved in autophagosome formation, is a reliable marker of poor prognosis in TN BC, validating this prognostic value at both the mRNA and protein levels in several independent cohorts. We also show that LC3B has no prognostic value for other BC subtypes (Luminal or HER2 BC), thus revealing a specific impact of autophagy on TN tumors. Autophagy is essential for the proliferative and invasive properties in 3D of TN BC cells characterized by high LC3B levels. Interestingly, the activity of the transcriptional co-activator YAP1 (Yes-associated protein 1) is regulated by the autophagy process and we identify YAP1 as a new actor in the autophagy-dependent proliferative and invasive properties of high-LC3B TN BC. Finally, inhibiting autophagy by silencing ATG5 or ATG7 significantly impaired high-LC3B TN tumor growth in vivo. Moreover, using a patient-derived TN tumor transplanted into mice, we show that an autophagy inhibitor, chloroquine, potentiates the effects of chemotherapeutic agents. Overall, our data identify LC3B as a new prognostic marker for TN BC and the inhibition of autophagy as a promising therapeutic strategy for TN BC patients.
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
Creators: name: Lefort, Sylvain
name: Joffre, Carine
name: Kieffer, Yann
name: Givel, Anne-Marie
name: Bourachot, Brigitte
name: Zago, Giulia
name: Bieche, Ivan
name: Dubois, Thierry
name: Meseure, Didier
name: Vincent-Salomon, Anne
name: Camonis, Jacques
name: Mechta-Grigoriou, Fatima
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify autophagy as a key mechanism in the progression and chemoresistance of a subset of TN tumors. We demonstrate that LC3B, a protein involved in autophagosome formation, is a reliable marker of poor prognosis in TN BC, validating this prognostic value at both the mRNA and protein levels in several independent cohorts. We also show that LC3B has no prognostic value for other BC subtypes (Luminal or HER2 BC), thus revealing a specific impact of autophagy on TN tumors. Autophagy is essential for the proliferative and invasive properties in 3D of TN BC cells characterized by high LC3B levels. Interestingly, the activity of the transcriptional co-activator YAP1 (Yes-associated protein 1) is regulated by the autophagy process and we identify YAP1 as a new actor in the autophagy-dependent proliferative and invasive properties of high-LC3B TN BC. Finally, inhibiting autophagy by silencing ATG5 or ATG7 significantly impaired high-LC3B TN tumor growth in vivo. Moreover, using a patient-derived TN tumor transplanted into mice, we show that an autophagy inhibitor, chloroquine, potentiates the effects of chemotherapeutic agents. Overall, our data identify LC3B as a new prognostic marker for TN BC and the inhibition of autophagy as a promising therapeutic strategy for TN BC patients.
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
Creators: name: Lefort, Sylvain
name: Joffre, Carine
name: Kieffer, Yann
name: Givel, Anne-Marie
name: Bourachot, Brigitte
name: Zago, Giulia
name: Bieche, Ivan
name: Dubois, Thierry
name: Meseure, Didier
name: Vincent-Salomon, Anne
name: Camonis, Jacques
name: Mechta-Grigoriou, Fatima
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify autophagy as a key mechanism in the progression and chemoresistance of a subset of TN tumors. We demonstrate that LC3B, a protein involved in autophagosome formation, is a reliable marker of poor prognosis in TN BC, validating this prognostic value at both the mRNA and protein levels in several independent cohorts. We also show that LC3B has no prognostic value for other BC subtypes (Luminal or HER2 BC), thus revealing a specific impact of autophagy on TN tumors. Autophagy is essential for the proliferative and invasive properties in 3D of TN BC cells characterized by high LC3B levels. Interestingly, the activity of the transcriptional co-activator YAP1 (Yes-associated protein 1) is regulated by the autophagy process and we identify YAP1 as a new actor in the autophagy-dependent proliferative and invasive properties of high-LC3B TN BC. Finally, inhibiting autophagy by silencing ATG5 or ATG7 significantly impaired high-LC3B TN tumor growth in vivo. Moreover, using a patient-derived TN tumor transplanted into mice, we show that an autophagy inhibitor, chloroquine, potentiates the effects of chemotherapeutic agents. Overall, our data identify LC3B as a new prognostic marker for TN BC and the inhibition of autophagy as a promising therapeutic strategy for TN BC patients.
title: The circular economy practices of the tapioca starch industry in northeastern Thailand
Creators: name: Charoenrungrueang, Chitphinan
name: Sawettham, Arunrat
name: Ngeoywijit, Sumalee
name: Weesaphen, Sarun
name: Kosacka-Olejnik, Monika
Publisher: name: Publishing House of Poznan University of Technology
Year: 2021

description: Zeszyty Naukowe Politechniki Poznańskiej. Organizacja i Zarządzanie, 84, 5-18
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
Creators: name: Pyarajan, S.
name: Ho, Y.-L.A.
name: Zhao, H.
name: Marouli, E.
name: Raghavan, S.
name: Hunter-Zinck, H.
name: Huffman, J.E.
name: Wilson, P.W.F.
name: Tsao, P.S.
name: O'Donnell, C.J.
name: Gaziano, J.M.
name: Assimes, T.L.
name: Lange, L.A.
name: Sun, Y.V.
name: Lange, E.
name: Tcheandjieu, C.
name: Cho, K.
name: Liu, C.
name: Huang, J.
name: Voight, B.F.
name: Litkowski, E.
name: North, K.E.
name: Hauser, E.R.
name: Chang, K.-M.
Publisher: name: Public Library of Science
Year: 2022

description: Background Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (MR-PheWAS) using clinical and genetic data from a national healthcare system biobank. Methods and findings Analyses were performed using data from the US Veterans Affairs (VA) Million Veteran Program in non-Hispanic White (EA, n = 222,300) and non-Hispanic Black (AA, n = 58,151) adults in the US. We estimated height genetic risk based on 3290 height-associated variants from a recent European-ancestry genome-wide meta-analysis. We compared associations of measured and genetically-predicted height with phenome-wide traits derived from the VA electronic health record, adjusting for age, sex, and genetic principal components. We found 345 clinical traits associated with measured height in EA and an additional 17 in AA. Of these, 127 were associated with genetically-predicted height at phenome-wide significance in EA and 2 in AA. These associations were largely independent from body mass index. We confirmed several previously described MR associations between height and cardiovascular disease traits such as hypertension, hyperlipidemia, coronary heart disease (CHD), and atrial fibrillation, and further uncovered MR associations with venous circulatory disorders and peripheral neuropathy in the presence and absence of diabetes. As a number of traits associated with genetically-predicted height frequently co-occur with CHD, we evaluated effect modification by CHD status of genetically-predicted height associations with risk factors for and complications of CHD. We found modification of effects of MR associations by CHD status for atrial fibrillation/flutter but not for hypertension, hyperlipidemia, or venous circulatory disorders. Conclusions We conclude that height may be an unrecognized but biologically plausible risk factor for several common conditions in adults. However, more studies are needed to reliably exclude horizontal pleiotropy as a driving force behind at least some of the MR associations observed in this study.
Transmitting Cultural Values Through Music Education
Creators: name: Clemson, Chigwindiri
Publisher: name: Zenodo
Year: 2024

description: : Music education in Zimbabwe plays a significant role in conveying cultural values and norms. This study focuses mainly on the role of music education in preserving and promoting Zimbabwean cultural heritage. The methodology involves a case study of five music teachers from diverse cultural backgrounds to survey various cultural events and uses purposive sampling techniques to gather information from knowledgeable individuals. The findings and discussions cover different aspects such as the incorporation of cultural education in the music curriculum, the impact of globalization on Zimbabwean culture, teaching methods including field research, storytelling, performance of traditional dances, instrument making, traditional songs, and motivating students through cultural activities, as well as preservation approaches. The study explores how music education serves as a conduit through which traditional practices, beliefs, values, and norms are preserved and handed down from one generation to another. Through assessing the experiences and insights of the selected participants, this research showed how music education contributes to the sustainability of Zimbabwean cultural identity and heritage
Transformative education: philosophical, psychological, and pedagogical dimensions
Creators: name: Yacek, Douglas
name: Rödel, Severin Sales
name: Karcher, Martin
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: 370
subject: Pädagogik
subject: Erziehungsphilosophie
subject: Lebensführung
subject: Pädagogische Psychologie

description: Ed Theory;70(5)
Globalization and children’s diets: The case of Maya of Mexico and Central America
Creators: name: Azcorra, Hugo
name: Wilson, Hannah
name: Vasquez-Vasquez, Adriana
name: Avila, Maria Luisa
name: Castillo-Burguete, Maria Teresa
name: Dickinson, Federico
name: Varela-Silva, Maria Ines
Publisher: name: figshare
Year: 2014
Subjects: subject: Anthropology
subject: FOS: Sociology

description: Globalization is, in part, an economic force to bring about a closer integration of national economies. Globalization is also a biological, social and ideological process of change. Globalization results in powerful multinational corporations imposing their products on new markets. Food globalization brings about nutritional transitions, the most common being a shift from a locally-grown diet with minimally refined foods, to the modern diet of highly processed foods, high in saturated fat, animal products and sugar, and low in fiber. This paper will examine the influences of food globalization using the Maya of Mexico as a case study. The Maya people of Mexico are a poignant case. Maya health and culture has deteriorated as a result, with highly processed foods affecting physical growth and health of Maya children and their families. The case of the Maya is not isolated and we must come to terms with food globalization if we are to translate research into better child health and well-being.
Illich in the library: putting theory into practice
Creators: name: Grace, Dan
Publisher: name: figshare
Year: 2014
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: The purpose of this paper is to draw out critical concepts and ideas useful to understanding how the public library can help build resilient communities, particularly in relation to the challenges posed by climate change, from the theories of Ivan Illich. Resilience is identified as a problematic concept in need of critical understanding if it is to be of utility in the struggle against climate change. Critical theory is advanced as the means through which this can be achieved, being put into practice through praxis, the dialectic between theory and action. Specifically, Illich’s ideas of the commons, conviviality and false public utility are advanced as potential starting points for a process of transformational community resilience in relation to the public library
Maternal Short Stature Does Not Predict Their Children’s Fatness Indicators in a Nutritional Dual-Burden Sample of Urban Mexican Maya
Creators: name: Wilson, Hannah
name: Dickinson, Federico
name: Griffiths, Paula L
name: Bogin, Barry
name: Hobbs, Matthew
name: Varela-Silva, Maria Ines
Publisher: name: figshare
Year: 2014
Subjects: subject: Diseases
subject: Anthropology
subject: FOS: Sociology

description: The co-existence of very short stature due to poor chronic environment in early life and obesity is becoming a public health concern in rapidly transitioning populations with high levels of poverty. Individuals who have very short stature seem to be at an increased risk of obesity in times of relative caloric abundance. Increasing evidence shows that an individual is influenced by exposures in previous generations. This study assesses whether maternal poor early life environment predicts her child’s adiposity using cross sectional design on Maya schoolchildren aged 7–9 and their mothers (n 5 57 pairs). We compared maternal chronic early life environment (stature) with her child’s
adiposity (body mass index [BMI] z-score, waist circumference z-score, and percentage body fat) using multiple linear regression, controlling for the child’s own environmental exposures (household sanitation and maternal parity).
РАННЕВИЗАНТИЙСКИЕ КАПИТЕЛИ ИЗ ХЕРСОНЕСА ТАВРИЧЕСКОГО*
Creators: name: Хрушкова Людмила Георгиевна
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Византия
Крым
Херсонес
базилики
декор
мрамор
элементы интерьера
капители

description: В статье впервые публикуется коллекция ранневизантийских мраморных изделий из Херсонеса Таврического, которая хранится в Государственном историческом музее (ГИМ, Москва). Она включает несколько капителей, фрагментов алтарных преград и других элементов интерьера. Предметы из ГИМ рассмотрены в сопоставлении с большой коллекцией мраморов, которая находится в Государственном историко-археологическом музее-заповеднике «Херсонес Таврический» (ГИАМЗ ХТ) в древнем Херсонесе (совр. Севастополь). Статья дает представление о масштабах и характере импорта мрамора из византийских проконнесских мастерских в Херсонес, преимущественно во второй половине V и в VI вв.
Taeniasis case report in our media
Creators: name: Gutiérrez-Fernández, José
name: Gomez, Jairo Lopez
name: Villena, Jaime Jiménez
Publisher: name: figshare
Year: 2014
Subjects: subject: Pathology
subject: Medicine
subject: Parasitology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Diseases
subject: Ecology
subject: FOS: Biological sciences

description: Se describe un caso clínico de teniasis de gran interés por la improbabilidad de encontrarlo en nuestro medio. A case of great interest teniasis unlikely to find in our environment is described.
Molecular epidemiology of GAS virulence factors in invasive disease in tropical and subtropical Australia
Creators: name: Del Vecchio, Armando
Publisher: name: Charles Darwin University
Year: 2003

description: Streptococcus pyogenes or group A streptococcus (GAS) is a common human pathogen responsible for a variety of diseases ranging from the uncomplicated common sore throat (pharyngitis), pyoderma (impetigo) to more life threatening conditions such as bacteremia, necrotising fasciitis, and toxic shock like syndrome. Recurrent episodes may lead to serious sequelae such as acute glomerulonephritis (APSGN) and acute rheumatic fever. Streptococcus pyogenes strains may express several distinct fibronectin binding proteins (FBP's) which are considered as major streptococcal adhesins. SfbI a GAS FBP was shown in vitro to promote both adherence and internalisation of the bacterium into host cells and has been implicated in persistence. In the tropical Northern Territory (NT) of Australia, skin and not throat is the major reservoir for isolation of GAS. Recent studies suggest association of NADase in conjunction with streptolysin O a pore forming cytolysin, in subsequent cellular toxicity and tissue destruction in invasive disease. It has also been suggested as an alternate mechanism in GAS inernalisation and subsequent persistence. This thesis investigated the association of FBP's, NADase and streptococcal pyrogenic exotoxins with invasive disease propensity in isolates from bacteremia, necrotising fasciitis and uncomplicated infections. We have used molecular biological tools such as polymerase chain reaction (PCR), southern hybridisation using radiolabelled DNA probes, serological and fluorometric assays on invasive and non-invasive cases from the NT and South Western Sydney (SWS) to screen for these particular phenotypes. The sample isolates included seventy five strains from the NT (INVASIVES = 37, NON-INVASIVE= 38 and 39 from SWS (INV ASIVES = 26, NON-INVASIVE = 13). The results showed that although sfbI the gene for the FBP SfbI implicated in propensity for invasiveness and persistence is found in 60 % of NT isolates there was no significant association with invasive disease and the same was for SWS. Interestingly prtfII although not significant with a p value of 0.0732 showed a trend towards association being represented more often in invasive case isolates. In both the NT and SWS no significant association between NADase production and posession of the three streptococcal pyrogenic exotoxins with invasive disease was found. There was however significantly more expression overall of speC and NADase in SWS than the NT, p = 0.0034, p = 0.0013 respectively. This is interesting, given that the overall crude incidence of severe GAS diseases in the indigenous population of the NT is much higher than SWS. It appears that these results do not directly implicate adhesins, NADase or streptococcal pyrogenic exotoxins with invaisve disease in the NT and SWS.
Antibacterial and antioxidant constituents of Acalypha wilkesiana
Creators: name: Chinedu P. Anokwuru
name: Sinisi, Annamaria
name: Amidou Samie
name: Taglialatela-Scafati, Orazio
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry

description: This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of Acalypha wilkesiana. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, geraniin, corilagin, quadrangularic acid M and shikimic acid were purified and isolated. Shikimic acid, reported for the first time from this plant, proved to be the major metabolite of the extract. All the four isolated compounds showed bactericidal activity against extended spectrum beta-lactamase-producing Klebsiella pneumoniae (700603), while corilagin was the single compound to exhibit antioxidant activity (IC50 53 μg/mL).
Essential oil of Cephalotaxus griffithii needle inhibits proliferation and migration of human cervical cancer cells: involvement of mitochondria-initiated and death receptor-mediated apoptosis pathways
Creators: name: Moirangthem, Dinesh Singh
name: Surbala Laishram
name: Virendra Singh Rana
name: Jagat Chandra Borah
name: Talukdar, Narayan Chandra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry

description: This study was conducted to determine the effect of Cephalotaxus griffithii needle essential oil (CGNO) on proliferation and migration of human cervical cancer (HCC) cells. CGNO treatment decreased the viability of all the tested HCC (HeLa, ME-180 and SiHa) cells. Morphological and DNA fragmentation analysis of CGNO-treated HeLa cells indicated the involvement of apoptosis in inducing HCC cell death. CGNO increased mitochondrial membrane depolarisation and upregulated the expression of caspase-9, caspase-8, caspase-3 and cleaved-PARP. The activity of caspase-8 and caspase-9 was also significantly increased. Wound healing and transwell migration assay demonstrated that CGNO significantly inhibited the migration of HeLa cells to close a scratched wound and also inhibited their migration through filter towards a chemotactic stimulus. Taken together, these results indicated that CGNO inhibited the proliferation and migration of HCC cells. Of note, CGNO induced HeLa cell death through mitochondria-initiated and death receptor-mediated apoptosis pathway.
IN03208 Aṁpiṭiya Rock Inscription
Creators: name: Codrington, H. W.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03208
Epigraphia Zeylanica
Aṁpiṭiya

description: IN03208 Aṁpiṭiya Rock Inscription - Transcript and Translation Source: Codrington, H. W. (1934–41). ‘No. 35. The Aṁpiṭiya Rock-Inscription,’ Epigraphia Zeylanica 4, pp. 271–273.
Extended Supporting Information - Toward the Scalable, Rapid, Reproducible, and Cost-Effective Synthesis of Personalized Nanomedicines at the Point of Care
Creators: name: Wilhelm, Stefan
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400302
subject: Biomaterials
classificationCode: 400301
subject: Biofabrication

description: These files represent the extended supporting information for the following publication:Toward the Scalable, Rapid, Reproducible, and Cost-Effective Synthesis of Personalized Nanomedicines at the Point of CareHamilton Young, Yuxin He, Bryan Joo, Sam Ferguson, Amberlynn Demko, Sarah K. Butterfield, James Lowe, Nathan F. Mjema, Vinit Sheth, Luke Whitehead, Maria J. Ruiz-Echevarria, and Stefan WilhelmNano Letters, 2024, https://doi.org/10.1021/acs.nanolett.3c04171 Extended Supporting InformationAll optimized 3D printer files and Excel files can be downloaded:-Output Tubing Holder.stl: 3D model to hold the synthesized liposomes-T-Mixer Holder.stl: 3D model to hold the T-Mixer-X X Motor Stepper Mount.stl: 3D model placed on the beginning portion of the syringe pumps-E Stepper Mount.stl: 3D model placed on the beginning portion of the syringe pumps-Ender3_SyringePumpCalibration.xlsx: Excel spreadsheet used for calibrating the step sizes to atarget syringe in the GCODE. A “Read Me” is included to help familiarize the reader to the file.
A new ester coumarin from Ferula Persica wild, indigenous to Iran
Creators: name: Razavi, Seyed Mehdi
name: Janani, Mehrnoush
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Ecology
subject: Chemistry
subject: Pharmacology
subject: Biochemistry

description: Ferula persica wild (Apiaceae) is a perennial herb indigenous to Iran. It has been used in folk medicine for treatment of diabetes, lowering of blood pressure and for antispasmodic, carminative, laxative and expectorant effects in central Iran. Dried ground roots of F. persica (150 g) were extracted sequentially with n-hexane, dichloromethane and methanol (MeOH), 500 ml each, using a Soxhlet apparatus. The n-hexane extract of the roots (3 g) was subjected to vacuum liquid chromatography on silica gel, eluting with solvent mixtures of increasing polarity: 100% n-hexane–ethyl acetate (EtOAc), to yield a number of fractions, Fraction 4 (80% EtOAc in n-hexane) was further analysed by preparative TLC (mobile phase was 12% acetone in chloroform) to yield a coumarin ester (10.1 mg, Rf = 0.31, blue florescent). The structure of the isolated compound was elucidated by spectroscopic means. The compound is 7-O-(4,8,12 -trihydroxy-4,8,12-trimethyl-tridecanoyl)-coumarin, named, ferulone C as a new natural product.
Suomalaisten arseenialtistus elintarvikkeista. Tiivistelmä kansallisen riskinarvioinnin tuloksista
Creators: name: Suomi, Johanna
Publisher: name: Zenodo
Year: 2020
Subjects: subject: inorganic arsenic
subject: exposure assessment
subject: http://id.agrisemantics.org/gacs/C1470
subject: http://id.agrisemantics.org/gacs/C3860

description: This is a short document for the general reader on the dietary exposure of Finnish children and adults to arsenic. The results summarized in this document have been presented in more detail in two national risk assessments: https://doi.org/10.5281/zenodo.851785
 and
 http://doi.org/10.5281/zenodo.3772613
description: FI; PDF; johanna.suomi@ruokavirasto.fi