Additional file 1 of Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Santé cohort study
Creators: name: Kesse-Guyot, Emmanuelle
name: Rebouillat, Pauline
name: Payrastre, Laurence
name: Allès, Benjamin
name: Fezeu, Léopold K.
name: Druesne-Pecollo, Nathalie
name: Srour, Bernard
name: Bao, Wei
name: Touvier, Mathilde
name: Galan, Pilar
name: Hercberg, Serge
name: Lairon, Denis
name: Baudry, Julia
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1 Table S1. Components, scoring and weighting used for sPNNS-GS2 cFigureS4ek. Table S2. Sensitivity analyses of the associations between organic food consumption and risk of T2D, NutriNet-Santé study, 2014–2019*. Abbreviations: CI: confidence interval, HR: Hazard ratio, PNNS-GS2: Programme National Nutrition Santé-guideline score 2, Q: quintile, T2D: type 2 diabetes. * Values are mean differences (95% confidence intervals). 5 points correspond to 5% of the contribution of OF to the diet. Model are adjusted for age (time-scale), gender, familial history of diabetes, physical activity, occupation, marital status, education, monthly income per unit, smoking status, sPNNS-GS2, energy intake, alcohol consumption and body mass index. 1P for continuous independent variable. 2T2D cases occurring during the first year of follow-up were excluded from the sample (final n = 33,162. 199 cases). 3Participants developing a cardiovascular disease during the follow-up or before were excluded from the sample (final n = 32,468, 273 cases). 4Participants with hypertension or dyslipidemia at baseline were removed (final n = 24,316. 85 cases). 5Model was further adjusted for consumption of processed meat, whole grain and sweetened beverages. 6Model was further adjusted for intake of saturated fatty acids, sugar, sodium and fiber. 7Residual of the regression of organic food consumption on sPNNS-GS2 was considered as principal exposure. 8Model with sPNNE-GS2 replaced by 4 dietary factors extracted by principal component analysis. Table S3. Mediation of the association between organic food consumption and risk of T2D by a healthy diet, NutriNet-Santé study, 2014–2019, N = 33,256*. Abbreviations: Q, Quintile; HR, hazard ratio. * The direct effect corresponds to the direct relation between organic food consumption and T2D, and the indirect effect corresponds to the relation mediated by sPNNS-GS2 (diet quality, in deciles) as described in the supplemental material. Values are hazard ratio and 95% confidence interval adjusted for age (time-scale), gender, family history of diabetes, physical activity, occupation, marital status, education, monthly income per unit, smoking status, energy intake, alcohol consumption and body mass index. 1Values correspond to the percentage of the total association mediated by sPNNS-GS2. Table S4. Association between the proportion of organic food in the diet and risk of T2D, adjusted for the Medi-Lite score, NutriNet-Santé study, 2014–2019, N = 33,256*. Abbreviation: Q: sex-specific quintile. *Values are Hazard ratio (95% confidence intervals), 5 points correspond to 5% of the contribution of OF to the diet. 1P for trend modeling quintile as ordinal independent variable. 2P for continuous independent variable. 3Model 1 is adjusted for age (time-scale), gender, familial history of diabetes, physical activity, occupation, marital status, education, monthly income per unit, smoking status, MEDI-LITE, energy intake and alcohol consumption. 4Model 2 is model 1 adjusted for body mass index. 5Model 3 is model 1 adjusted for total plant food consumption. 6Model 4 is model 3 adjusted for body mass index. 7Model 5 is model 1 adjusted for total animal food consumption. 8Model 6 is model 5 adjusted for body mass index. S5 Material.