cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Generic BI Application for Real-time Monitoring of Care Processes
Creators: name: Baffoe, Shirley A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Care Process Monitoring
Business Process Monitoring
Real-time Patient Flow Monitoring
Real-time data integration architecture
Real-time care process monitoring
Performance Monitoring
State Monitoring Engine
Events Processing

description: Patient wait times and care service times are key performance measures for care processes in hospitals. Managing the quality of care delivered by these processes in real-time is challenging. A key challenge is to correlate source medical events to infer the care process states that define patient wait times and care service times. Commercially available complex event processing engines do not have built in support for the concept of care process state. This makes it unnecessarily complex to define and maintain rules for inferring states from source medical events in a care process. Another challenge is how to present the data in a real-time BI dashboard and the underlying data model to use to support this BI dashboard. Data representation architecture can potentially lead to delays in processing and presenting the data in the BI dashboard. In this research, we have investigated the problem of real-time monitoring of care processes, performed a gap analysis of current information system support for it, researched and assessed available technologies, and shown how to most effectively leverage event driven and BI architectures when building information support for real-time monitoring of care processes. We introduce a state monitoring engine for inferring and managing states based on an application model for care process monitoring. A BI architecture is also leveraged for the data model to support the real-time data processing and reporting requirements of the application’s portal. The research is validated with a case study to create a real-time care process monitoring application for an Acute Coronary Syndrome (ACS) clinical pathway in collaboration with IBM and Osler hospital. The research methodology is based on design-oriented research.
Development of New Bioorthogonal Strain-Promoted Alkyne-Nitrone Cycloaddition Methodology for Applications in Living Systems
Creators: name: Chigrinova, Mariya
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Bioorthogonal
Strain-promoted
Alkyne
Nitrone
Cycloaddition
Kinetic
Biarylazacyclooctynone (BARAC)
Rearrangement
Biomolecule Labelling
Applications
Bioconjugation
Imaging

description: Nitrones are alternatives to azides in rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes. To evaluate the differences between nitrones and azides we have performed kinetic studies of strain-promoted alkyne-nitrone cycloaddition (SPANC) reactions of biarylazacyclooctynone (BARAC) with various acyclic and cyclic nitrones. The reactions were conducted under pseudo first-order reaction conditions using UV-visible spectroscopy. The reactivity of the acyclic nitrones was evaluated by varying the stereoelectronic and steric character of substituents at both the α-aryl and nitrogen positions. Cyclic nitrone reactivity was assessed according to the size of the ring and additional steric and strain effects. The obtained second-order rate constants for reactions of BARAC with cyclic nitrones were found to be greater than those for acyclic nitrones. However, all nitrones employed in the kinetic studies herein displayed significantly greater reactivity than azides in the analogous cycloadditions with BARAC. It is of particular note that the five-membered cyclic nitrones showed exceptional reactivity and, if used as rapid alternatives to azides in reactions with BARAC, can increase the reaction rates by up to 50 fold. An attempt to synthesize an allylated BARAC analogue is also described; the rearrangement reaction leading to the unexpected products is reported. The reaction rate for the novel rearrangement under both neutral and acidic conditions was obtained and plausible mechanisms for formation of products are proposed. Based on the results reported herein we anticipate that development of a labelling probe based on BARAC and a five-membered cyclic nitrone would allow for significant decrease of the concentrations of labelling reagents, thereby minimizing reaction time and reagent usage in life sciences applications. Nevertheless, a possible labelling decrease due to side reactions should be given consideration for prolonged labelling.
DNA paternity testing without the knowledge or consent of the mother: new technology, new choices, new debates
Creators: name: Gilding, Michael
Publisher: name: Swinburne
Year: 2024

description: New technologies are creating new choices and dilemmas in contemporary families. DNA parentage testing exemplifies this process. This article examines the contentious issue of DNA paternity testing without the knowledge or consent of the mother. It discusses terminology; the context, including a brief overview of the DNA parentage testing industry; public opinion; proposed regulation; a possible way forward in the regulation of tests.
Interactions Between Dopamine Neurons and Radial Glial Cells In the Adult Goldfish Forebrain
Creators: name: Xing, Lei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Radial glial cell
Dopamine
Aromatase
Teleost

description: Aromatase is the only enzyme that converts androgens into estrogens, which is found in the brain, testes and ovaries. In teleosts, brain aromatase is exclusively expressed in radial glial cells, which are the abundant stem-like non-neuronal progenitors involved in neuroendocrine functions and neurogenesis in the central nervous system. With little information about radial glial cell regulation by neurotransmitters and neurohormones available, the overall goal of this thesis is to investigate the interactions between dopamine neurons and radial glial cells in the adult goldfish (Carassius auratus) forebrain. Immunocytochemistry and confocal imaging revealed a close anatomical relationship between dopamine neurons and radial glial cells along the ventricular surface in the telencephalon. Transcriptional regulation of brain aromatase by dopamine indicated a brain region-specific pattern and suggested the involvement of other regulators in the goldfish forebrain. A novel goldfish primary radial glial cell culture model was established and characterized for brain aromatase regulation studies. Pharmacological studies demonstrated that specific activation of dopamine D1 receptors up-regulates brain aromatase through a cAMP-dependent molecular mechanism, which can be enhanced or attenuated by the product of aromatase action, 17β-estradiol. Proteome profiling and the response following treatment with the specific dopamine D1 receptor agonist SKF 38393 revealed that proteins involved in cell proliferation and growth are regulated through small molecules- and transcription factors-mediated signaling pathways. Analysis of genes related to radial glial cell and dopamine neuron functions demonstrated that glial activation and dopamine neuron recovery are estrogen-dependent in a neurotoxin MPTP-induced goldfish model of Parkinson’s disease. This thesis illustrates novel molecular mechanisms underlying brain aromatase regulation as well as radial glial cell function regulation and provides a framework for future investigation of existing endocrine disruptors modulating neurosteroid levels in the teleost brain.
Molecular Regulation of Satellite Cell Maintenance and Differentiation During Adult Myogenesis
Creators: name: Jones, Andrew E. D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Myogenesis
Satellite Cell
Pax7
Follistatin
Alternative Splicing
Myogenic Differentiation

description: The post-natal regenerative capacity of skeletal muscle is attributed to myogenic satellite cells, which function as lineage-committed precursors to replace terminally differentiated muscle. The development and differentiation of the satellite cell lineage is regulated by Pax7 and the myogenic regulatory factors. While the expression of Pax7 is vital to the function of the satellite cell compartment, the paired domain alternative splicing events that regulate its DNA binding potential remain elusive. Interestingly, the generation of Pax7 splice variants differentially regulate Myf5 expression. We performed a global analysis of two Pax7 isoforms, which differ by a glycine-leucine dipeptide, to determine how paired domain splicing events modify the ability of Pax7 to regulate target genes. To this end, we observe that although the homeodomain is important for Pax7 binding, these isoform differences in the paired domain can regulate Pax7 targets during myogenesis. In addition to further examining the role of Pax7 during satellite cell proliferation and maintenance, it remains important to understand their downstream differentiation potential. Since activation of the canonical Wnt signalling pathway results in reduced regenerative efficiency in vivo, we undertook a global analysis of satellite cell derived myoblasts to examine their ability to respond to canonical Wnt signalling. We demonstrate that Wnt/β-Catenin signalling drives myogenic differentiation, via the myogenin-dependent control of follistatin expression, further fine-tuning the myogenic differentiation process. The effects of canonical Wnt signalling on myogenic differentiation complement our observations regarding Pax7 alternative splicing during myoblast proliferation and provide a greater comprehensive understanding of the molecular regulation of satellite cell development and differentiation during adult myogenesis.
HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish
Creators: name: Eisa-Beygi, Shahram
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Intracerebral hemorrhage
stroke
zebrafish
etiology
pathophysiology
development
vascular development

description: Intracerebral hemorrhage (ICH) is a severe form of stroke, with a high mortality rate and often resulting in irreversible neurological deterioration. Although animal studies have provided insight into the etiology of the disease, many of the causative genes and mechanisms implicated in cerebral-vascular malformations are unknown. Treatment options remain ineffective. With the present models, the pathophysiological consequences of ICH can only be assessed in situ and after histological analysis. Furthermore, common deficiencies of the current models include the heterogeneity, low expression and low reproducibility of the desired phenotype. Hence, there is a requirement for novel approaches to model ICH pathogenesis. Zebrafish (Danio rerio) has gained recognition as a vertebrate model for stroke research. Through a combination of pharmacological blockers, metabolite rescue, genetic approaches, and confocal imaging analysis, I demonstrate a requirement for the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway in regulating developmental cerebral-vascular stabilization. A transient loss in HMGCR function induces ICH, characterised by progressive dilation of blood vessels, vascular permeability and vessel rupture. These effects are likely due to reduced prenylation of Rho GTPases, evidenced by morpholino-mediated blocking of the prenylation pathway and in vivo assessment of endothelial-specific localization of cdc42, a Rho GTPase family protein. These results are in conformity with recent clinical and experimental evidence. I have further shown that this model consistently replicates common pathoghysiological processes associated with ICH. The hemorrhages are associated with the disruption of the blood-brain barrier, vessel disintegration, hematoma expansion and edema into the adjacent brain regions. Also, enhanced apoptosis, activation of inflammatory mediators in the periphery of the hematoma, enriched heme oxygenase 1 (HO-1) expression and localised thrombosis were observed in these embryos. I show that the patterning and distribution of catecholaminergic neurons, response to sensory stimulus and swimming speed were impaired as a consequence of ICH. These results suggest that HMGCR contributes to cerebral-vascular stabilisation through Rho GTPase mediated-signalling and that zebrafish can serve as a powerful paradigm for the systemic analysis of the etiological and pathophysiological underpinnings of ICH and can help establish the basis for future studies into screening for putative therapeutics and elucidating mechanisms aiding functional recovery.
Predicting Reactive and Proactive Relational Aggression in Early Adolescence as a Function of Individual Differences in Machiavellianism, Empathy, and Emotion Regulation
Creators: name: Pursoo, Tiffany
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: relational aggression
reactive aggression
proactive aggression
empathy
Machiavellianism
emotion regulation
child
adolescent
school
individual differences

description: Relational aggression encompasses behaviour meant to hurt others by destroying their friendships and reputation (Crick & Grotpeter, 1995). As peer relationships take on greater importance in early adolescence, relational aggression becomes more accepted and prevalent, yet perceived as equally or more harmful to its targets than physical aggression. The present study explored whether reactive and proactive subtypes of relational aggression were associated with an inability to empathize with others, regulate emotional states, and hold attitudes that it is acceptable to manipulate and harm others. Empathy, emotion regulation, and Machiavellianism’s roles in predicting reactive and proactive relational aggression was examined using Crick and Dodge’s (1994) reformulated Social Information-Processing Theory’s framework. Reactive relational aggression was expected to be associated with low empathy and high emotion dysreglation. Proactive relational aggression was expected to be predicted by high empathy, low emotion dysregulation, and high Machiavellianism. Low empathy was expected to predict overt aggression indices. One hundred and thirty-three children (73 females, 60 males, Mage = 12.84 years) in grades 6 through 8 from five schools in a public Ontario schoolboard were recruited. Caregivers completed a measure of their child’s emotions and behaviours (The Emotion Regulation Checklist; Shields & Cicchetti, 1995). Participating students completed four self-report measures assessing relational and overt aggression (Children’s Social Behaviour Scale – Self-Report; Crick & Grotpeter, 1995), proactive and reactive subtypes of aggression (Little, Jones, Henrich, & Hawley, 2003), empathy (Interpersonal Reactivity Index; Davis, 1980), and Machiavellianism (Kiddie Mach Scale; Christie & Geis, 1970) during one 60 minute session. Empathy, Machiavellianism, and emotion dysregulation scores were associated with total, reactive, and proactive relational aggression scores. When contrasting subtypes of aggression were controlled, however, these emotional and cognitive variables did not predict total and reactive relational aggression. There was a non-significant trend for higher levels of empathy to predict proactive relational aggression. Low empathy significantly predicted total and reactive overt aggression indices. Machiavellianism predicted reactive and proactive overt aggression. Emotion regulation was not a significant predictor in analyses. Results provide support for the role of Machiavellianism and empathy in relational aggression, particularly proactive or goal-oriented instances.
Automatic Generation of Goal Models from Regulations
Creators: name: Rashidi-Tabrizi, Rouzbahan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Goal models generation
Regulation modeling
Automatic goal modeling
Regulation compliance

description: Organizations in many domains such as healthcare, finances, telecommunications, educa-tion, and software development, must comply with an ever-increasing number of regula-tions, including laws and policies. In order to measure compliance to regulation, several recent approaches propose modelling regulations using goals and indicators. However, creating goal models for regulations is time consuming and prone to errors, especially as this is usually done manually. This thesis tackles this issue by automating some of the steps for creating goal models, and by offering better ways to create graphical views of goal models than what is currently available nowadays in goal modelling tools. The notation used in this thesis is the Goal-oriented Requirement Language (GRL), which is part of the User Requirements Notation standard and is supported by the jUCMNav tool. The concepts of regulations and their indicators are captured using a tab-ular presentation in Comma-Separated Value (CSV) files. An import mechanism is added to jUCMNav to automatically create regulation goal models from such files. The imported GRL model can then by visualized using novel features that enable the addition of multiple views/diagrams in an efficient and usable way.
Supplementary document for A dual-step method to manufacture polymeric GRIN lens with high refractive index range - 5425643.pdf
Creators: name: Loffredo, Fausta
name: Villani, Fulvia
name: De Girolamo Del Mauro, Anna
name: Sico, Giuliano
name: Nenna, Giuseppe
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supporting information
Chaos Based RFID Authentication Protocol
Creators: name: Chung, Harold
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: RFID
Chaos
ISO-14443
ISO-15693
Authentication
Cryptology

description: Chaotic systems have been studied for the past few decades because of its complex behaviour given simple governing ordinary differential equations. In the field of cryptology, several methods have been proposed for the use of chaos in cryptosystems. In this work, a method for harnessing the beneficial behaviour of chaos was proposed for use in RFID authentication and encryption. In order to make an accurate estimation of necessary hardware resources required, a complete hardware implementation was designed using a Xilinx Virtex 6 FPGA. The results showed that only 470 Xilinx Virtex slices were required, which is significantly less than other RFID authentication methods based on AES block cipher. The total number of clock cycles required per encryption of a 288-bit plaintext was 57 clock cycles. This efficiency level is many times higher than other AES methods for RFID application. Based on a carrier frequency of 13.56Mhz, which is the standard frequency of common encryption enabled passive RFID tags such as ISO-15693, a data throughput of 5.538Kb/s was achieved. As the strength of the proposed RFID authentication and encryption scheme is based on the problem of predicting chaotic systems, it was important to ensure that chaotic behaviour is maintained in this discretized version of Lorenz dynamical system. As a result, key boundaries and fourth order Runge Kutta approximation time step values that are unique for this new mean of chaos utilization were discovered. The result is a computationally efficient and cryptographically complex new RFID authentication scheme that can be readily adopted in current RFID standards such as ISO-14443 and ISO-15693. A proof of security by the analysis of time series data obtained from the hardware FPGA design is also presented. This is to ensure that my proposed method does not exhibit short periodic cycles, has an even probabilistic distribution and builds on the beneficial chaotic properties of the continuous version of Lorenz dynamical system.
Fetichismo e fantasmagoria no mundo do consumo (Fetishism and phantasmagoria in the world of consumption)
Creators: name: Castro, Julio Cesar Lemes De
Publisher: name: figshare
Year: 2020
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Anthropology
subject: FOS: Sociology
subject: 220399 Philosophy not elsewhere classified
subject: 220315 Philosophy of Religion
subject: 220317 Poststructuralism
subject: 220318 Psychoanalytic Philosophy
subject: 220405 Religion and Society
subject: 220499 Religion and Religious Studies not elsewhere classified
subject: Religious Studies
subject: 220319 Social Philosophy
subject: 160199 Anthropology not elsewhere classified
subject: 200203 Consumption and Everyday Life
subject: FOS: Other humanities
subject: 200299 Cultural Studies not elsewhere classified
subject: 200204 Cultural Theory

description: The term “fetishism,” which emerges in modernity, finds important applications in three different areas: anthropology, psychoanalysis, and political economy. Among these applications there are multiple correlations, including the fundamental role played in them by the visual dimension. Starting from the Marxist conception of commodity fetishism, Benjamin comes to emphasize this dimension through the notion of phantasmagoria, which refers to the most visible and exuberant aspects of commodity, their subjective impact and their spreading to other spheres of existence. Thus, he takes account of spectacular facets of the consumer world already detectable in the 19th century and anticipates further theoretical developments, represented, for example, by Debord, Haug, and Baudrillard. / O termo “fetichismo”, que surge na modernidade, encontra aplicações importantes em três diferentes áreas: a antropologia, a psicanálise e a economia política. Entre essas aplicações há várias correspondências, incluindo o papel fundamental nelas desempenhado pela dimensão da visualidade. Partindo da concepção marxista de fetichismo da mercadoria, Benjamin é levado a enfatizar tal dimensão por intermédio da noção de fantasmagoria, que remete aos aspectos mais visíveis e exuberantes da mercadoria, a seu impacto subjetivo e a seu espraiamento para outras esferas da existência. Dessa forma, ele dá conta de facetas espetaculares do mundo do consumo já detectáveis no século XIX e antecipa desenvolvimentos teóricos posteriores, representados, por exemplo, por Debord, Haug e Baudrillard.
Extended Einstein-Dirac-aether theory: Spinor modifications of the dynamic aether kinetic term
Creators: name: Balakin, Alexander B.
name: Efremova, Anna O.
Publisher: name: arXiv
Year: 2025
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In the framework of the Einstein-Dirac-aether theory the extended model is established, in which the backreaction of the spinor field on the unit vector field, describing the dynamic aether, is taken into account. For this purpose, we extended the Jacobson constitutive tensor, which enters the kinetic part of the Lagrangian of the unit vector (aetheric) field, by the terms containing spinor tensors and pseudotensors. The self-consistent system of master equations for the unit vector field, as well as, the spinor and gravitational fields is derived using the variation formalism in the framework of the effective field theory up to the second order in derivatives.
description: 5 pages, 0 figures, short communication based on the talk, presented on the Conference RUSGRAV-18
Virtually Arming Genre with Politics? An Analysis of Electronic Military Recruitment in Venezuela, Colombia, and the United States. A Multimodal Approach
Creators: name: Smith, Allison M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: social semiotics
multimodality
discourse analysis
reading path
Venezuelan military
Colombian military
United States Miltary

description: In this dissertation, I address the relationship between the content and design of governmental websites and the ideological interests of the overseeing political administrations. Three case studies contrast the contemporary political climates in the Bolivarian Republic of Venezuela, the Republic of Colombia, and the United Stastes with the form and function of their respective military recruitment homepages. Through a semiotic, and specifically multimodal lens, I aim to determine to what degree there is evidence of the governing poltical party’s ideological perspective on the websites. To accomplish this task, each case study is introduced by a brief contemporary history in order to provide a summary of key political events within state. Each case study then includes a detailed analysis of 3-4 governmental homepages. Within those analyses, a comprehensive multimodal analysis is conducted for the most evocative content on each homepage. Finally, conclusions are reached for each case study, paying special attention to the content found along the reading path.
Fetichismo e fantasmagoria no mundo do consumo
Creators: name: Castro, Julio Cesar Lemes De
Publisher: name: figshare
Year: 2016
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Anthropology
subject: FOS: Sociology

description: The term “fetishism,” which emerges in modernity, finds important applications in three different areas: anthropology, psychoanalysis, and political economy. Among these applications there are multiple correlations, including the fundamental role played in them by the visual dimension. Starting from the Marxist conception of commodity fetishism, Benjamin comes to emphasize this dimension through the notion of phantasmagoria, which refers to the most visible and exuberant aspects of commodity, their subjective impact and their spreading to other spheres of existence. Thus, he takes account of spectacular facets of the consumer world already detectable in the 19th century and anticipates further theoretical developments, represented, for example, by Debord, Haug, and Baudrillard. / O termo “fetichismo”, que surge na modernidade, encontra aplicações importantes em três diferentes áreas: a antropologia, a psicanálise e a economia política. Entre essas aplicações há várias correspondências, incluindo o papel fundamental nelas desempenhado pela dimensão da visualidade. Partindo da concepção marxista de fetichismo da mercadoria, Benjamin é levado a enfatizar tal dimensão por intermédio da noção de fantasmagoria, que remete aos aspectos mais visíveis e exuberantes da mercadoria, a seu impacto subjetivo e a seu espraiamento para outras esferas da existência. Dessa forma, ele dá conta de facetas espetaculares do mundo do consumo já detectáveis no século XIX e antecipa desenvolvimentos teóricos posteriores, representados, por exemplo, por Debord, Haug e Baudrillard.
Newborn Screening for Mucopolysaccharidosis I: Moving Forward Learning from Experience
Creators: name: Clarke, Lorne A.
name: Dickson, Patricia
name: Ellinwood, N. Matthew
name: Klein, Terri L.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: There have been significant advances allowing for the integration of mucopolysaccharidosis I into newborn screening programs. Initial experiences using a single-tier approach for this disorder have highlighted shortcomings that require immediate remediation. The recent evaluation of a second-tier biomarker integrated into the MPS I newborn screening protocol has been demonstrated to greatly improve the precision and predictive value of newborn screening for this disorder. This commentary urges newborn screening programs to learn from these experiences and improve newborn screening for mucopolysaccharidosis I and future mucopolysaccharidoses newborn screening programs by implementation of a second-tier biomarker analyte.
Supplementary document for A dual-step method to manufacture polymeric GRIN lens with high refractive index range - 5425643.pdf
Creators: name: Loffredo, Fausta
name: Villani, Fulvia
name: De Girolamo Del Mauro, Anna
name: Sico, Giuliano
name: Nenna, Giuseppe
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: supporting information
Spatiotemporal Non-Uniformity-Aware Online Task Scheduling in Collaborative Edge Computing for Industrial Internet of Things
Creators: name: Li, Yang
name: Zhang, Xing
name: Sun, Yukun
name: Wang, Wenbo
name: Lei, Bo
Publisher: name: arXiv
Year: 2025
Subjects: subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Mobile edge computing mitigates the shortcomings of cloud computing caused by unpredictable wide-area network latency and serves as a critical enabling technology for the Industrial Internet of Things (IIoT). Unlike cloud computing, mobile edge networks offer limited and distributed computing resources. As a result, collaborative edge computing emerges as a promising technology that enhances edge networks' service capabilities by integrating computational resources across edge nodes. This paper investigates the task scheduling problem in collaborative edge computing for IIoT, aiming to optimize task processing performance under long-term cost constraints. We propose an online task scheduling algorithm to cope with the spatiotemporal non-uniformity of user request distribution in distributed edge networks. For the spatial non-uniformity of user requests across different factories, we introduce a graph model to guide optimal task scheduling decisions. For the time-varying nature of user request distribution and long-term cost constraints, we apply Lyapunov optimization to decompose the long-term optimization problem into a series of real-time subproblems that do not require prior knowledge of future system states. Given the NP-hard nature of the subproblems, we design a heuristic-based hierarchical optimization approach incorporating enhanced discrete particle swarm and harmonic search algorithms. Finally, an imitation learning-based approach is devised to further accelerate the algorithm's operation, building upon the initial two algorithms. Comprehensive theoretical analysis and experimental evaluation demonstrate the effectiveness of the proposed schemes.
description: Accepted to IEEE Transactions on Mobile Computing
Umple C++ Code Generator
Creators: name: Sultan, Almaghthawi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: umepl
model-oriented software engineering
uml
model
modeling
metamodel
aop
aspect oriented
mdd
tdd
test-driven
testing
c++
cpp
object-oriented

description: We discuss the design and analysis of a code generator for C++, implemented in the Umple model-oriented programming technology. Umple adds UML constructs and patterns to various base programming languages such as Java and PhP. Umple code generators create code for those constructs, which can include UML associations and state machines, as well as patterns such as immutable and singleton. Base language methods are passed through unchanged along with the generated code. Creating a C++ code generator for Umple posed many challenges, all of which are discussed in this thesis: We had to focus on the appropriate C++ idioms and stylistic conventions to follow. We followed a test-driven development process to ensure that the resulting code was correct. To evaluate the work, we compared our C++ generator with those in other tools such as ArgoUML and IBM Rational Software Architect. We conclude that our C++ generator is superior in many ways to these widely used tools because it is more complete and generates better quality code.
French Immersion Teachers' Experiences with the Factors that Influence Student Attrition
Creators: name: Berube, Gabrielle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: French immersion
teacher experience
student attrition

description: This instrumental qualitative case study sought to explore the experiences of four Ontario elementary French immersion teachers with the factors that influence elementary student attrition, where French is the minority language. The study used the social constructivist approach to learning and development (Vygotsky, 1978), as well as the principles of interaction and continuity in experience (Dewey, 1971), to show that experience shapes learning within a social context. The three research questions that guided this study were: 1) According to a group of Ontario elementary French immersion teachers, what academic and social factors influence student attrition from French immersion?; 2) How are this group of teachers’ current teaching practices affected by their previous experiences with the academic and social factors that influence student attrition in French immersion, by their personal and professional learning experiences, as well as by their social context?; and 3) How might these teachers encourage students to stay in or leave French immersion? Two semi-structured individual interviews with each of the four participants were conducted. The interviews were audio recorded and transcribed verbatim for coding and analysis. Results suggest that academic and social factors influence student attrition, that the teachers regularly change their teaching approaches and strategies to address student attrition and to help their students learn French, and that the teachers have experience encouraging students to stay in and leave French immersion. The findings of the present study contribute to the literature on French immersion teachers’ experiences with the factors that influence student attrition.
Acute Appendicitis - Basics and Management
Creators: name: Baig, Mirza Altamish M.
Publisher: name: Zenodo
Year: 2020
Subjects: Appendix
Appendicitis
McBurney's point
Alvarado score
Gridirion Incision
Lanz Incision
Appendectomy

description: Acute appendicitis is a fairly commonly encountered condition among surgeons worldwide. Still, it may be overlooked due to the various differential diagnoses one must exclude when suspecting this condition. When untreated, it can complicate to form mucocoele, paracecal abscess, or diffuse peritonitis, increasing morbidity several fold. It can have different presentations in different age groups, and even due to the anatomical variations in the location of appendix. As such, careful and prompt management is necessary to improve quality of life of the patient.
description: {"references": ["Bailey & Love's Short Practice of Surgery, 27th Edition"]}
PsiNet LAB: Transformando la psicología con ciencia avanzada para una comprensión más profunda del comportamiento humano
Creators: name: García O'Diana, Angel
name: Quispe Callo, Gleni
name: Zumarán Baldeón, Álvaro
name: Mamani, Jefri Justo
name: Casa Chicata, Marcelo
Publisher: name: Zenodo
Year: 2024
Subjects: Ciencia Abierta
Open Science

description: Esta es una Historia de Ciencia Abierta en Acción escrita por sus representantes para compartir la iniciativa en canales de MetaDocencia y más allá. Si quieres enviar tu historia, completa el formulario.
Melanoma and Tanning: A Case Study of Sun Safety Knowledge and Practices Among 15 Canadian University Women
Creators: name: Bashir, Kainat
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Health
Melanoma
Youth
Cancer
Women
Beauty
Gender

description: The purpose of this thesis was to investigate the knowledge and perceptions on the sun, risks of prolonged exposure, tanning and beauty of young Canadian women. Conversations with 15 young pregnant women from the University of Ottawa were tape-recorded, transcribed, and then analyzed using thematic analysis and theories on gender and beauty. The results were divided into two articles, the first exploring the perception and knowledge young Canadian women have about the sun, tanning and its risks. In the first article, the themes generated were (a) perceptions of benefits and risks of sun exposure; (b) outdoor versus Indoor tanning; (c) conformity; (d) conflicting and ambiguous messaging; (e) self risk and other’s risk and; (f) no UV index awareness. The second article explores how the fifteen interviewees make sense of the sun safety messaging they are exposed to, and how they act on it. The themes identified were: (a) tanning as a social activity; (b) beauty; (c) base tanning; and (d) wearing SPF and reapplication. The overall conclusion to be drawn from this study is that while for the most part the group of women I interviewed was well informed when it came to sun safety and tanning, they still felt the pressure to tan from peers, society and the media. There were times when they shared that they were misinformed on the risks of engaging in harmful tanning practices. Further, the study contributed to finding that the vast majority of the participants admitted to not checking the UV index before going outdoors, either because they did not understand it or because they felt it would not make a difference to their daily practices and behaviours. This contradicted previous literature that emphasized on the connection Canadians often made with the environment and UV index. Impacts, implications, and future research directions are discussed in both articles.
title: Zur Idee von Open Digital Makerspaces
title: Last Friday's Lab Talk des DHELab der BBF | Bibliothek für Bildungsgeschichtliche Forschung des DIPF | Leibniz-Institut für Bildungsforschung und Bildungsinformation am 28. Februar 2025
titleType: Subtitle
Creators: name: Kaden, Ben
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Open Access
subject: Open Science
subject: Community-Based Participatory Research
subject: Open Research
subject: Digital Makerspaces

description: Zusammenfassung des Last Friday's Lab Talk des DHELab der BBF | Bibliothek für Bildungsgeschichtliche Forschung des DIPF | Leibniz-Institut für Bildungsforschung und Bildungsinformation am 28. Februar 2025Abstract: Der Vortragstext argumentiert für die stärkere Integration von Open-Access- und Open-Research-Prinzipien in so genannte Digital Makerspaces. Er schlägt vor, solche Angebote als „Open Digital Makerspaces“ zu konzipieren, die durch offene Zugänge, Kollaboration, Kompetenzvermittlung und die Förderung unerwarteter Kooperationen gekennzeichnet sind. Das Ziel ist die Gestaltung dieser Räume als inklusive Orte, an denen sich unterschiedliche Akteure an der Schnittstelle zwischen akademischer Wissenschaft und unterschiedlichen Öffentlichkeiten mit Daten, Objekten, Sammlungen einerseits und digitalen Methoden und Konzepten andererseits auseinandersetzen. So sollen sich sowohl die Kompetenzen und Perspektiven der Nutzenden als auch der Institutionen und das Verständnis von offener Wissenschaft weiterentwickeln.

The presentation argues in favour of the strong integration of open access and open research principles in so-called digital makerspaces. It proposes designing such services as ‘open digital makerspaces’, which are characterised by open access, collaboration, skills transfer and the facilitation of spontaneous collaborations. The intention is to design these spaces as inclusive places where different actors at the intersection between academic research and different communities and audiences can jointly engage with data, objects and collections as well as reflect on digital methods and concepts. The aim is to further develop both, the respective skills and viewpoints of users and institutions as well as an understanding of open science.
Mutational Analysis of the HIV-1 Tat Protein and its Role in Downregulating CD127 on CD8 T Cells
Creators: name: Sugden, Scott M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: HIV
CD127
CD8 T Cell
Interleukin-7
Tat

description: HIV Tat protein downregulates surface expression of the interleukin-7 receptor alpha-chain (CD127) on CD8 T cells resulting in impaired T cell proliferation and cytolytic capacity. Once taken up by CD8 T cells, Tat binds directly to the cytoplasmic tail of CD127 inducing receptor internalization and degradation. Given the important roles of CD127 in proper immune function, the Tat/CD127 interactions were characterized and the mechanisms required to induce receptor loss from the surface of CD8 T cells were investigated. Tat deletion mutants were generated each sequentially lacking a region of the protein. CD8 T cells isolated from HIV negative volunteers were exposed to exogenous or intracellular Tat proteins before surface CD127 expression was analyzed by flow cytometry. To characterize Tat/CD127 physical interactions, wild type Tat and Tat mutants were incubated with lysates from a CD127+ Jurkat cell line followed by CD127/Tat co-immunoprecipitation. The effect of Tat on CD127 post-translational modifications was also investigated. Removal of the N-terminus of Tat (aa 1-10 or aa 17-21) prevented Tat from downregulating CD127 and prevented Tat from binding CD127 as assessed by co-immunoprecipitation. Deletion of the basic region (aa 48-59) also prevented Tat from downregulating CD127 but did not prevent Tat from interacting physically as demonstrated by co-immunoprecipitation. Strikingly, endogenously expressed Basic Tat acted as a dominant negative mutant, causing an accumulation of CD127 at the cell surface. These observations suggest that Tat may bind CD127 via its N-terminus to disrupt the normal recycling of the receptor, and then recruit cellular endocytic machinery to the receptor via it’s basic region, to remove the receptor from the cell surface and target it for degradation. Furthermore, Tat encourages the ubiquitination of CD127 by recruiting the cytokine-inducible SH2 containing (CIS) protein to the receptor, possibly leading to accelerated CD127 internalization and proteasomal degradation. I propose a model whereby Tat binds CD127 via its N-terminal region then recruits CIS via its basic region. CIS in turn recruits a cellular E3 ubiquitin ligase to ubiquitin tag the receptor for internalization and proteasome degradation. This research may lead to novel treatments designed to maintain IL-7 signalling and strengthen CD8 T cell function in HIV+ persons.
Knowledge Management in Collaborative Environment and Service Oriented Organizations
Creators: name: Alaieri, Fahad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Knowledge Management
Collaborative Environment
Service Oriented Architecture
Service Oriented Organizations
Virtual Organisation

description: In this research, we propose a knowledge management architecture in a collaborative environment and service oriented organization. The architecture contains five components, including partners, knowledge bases, portals, pipes, and cloud. Each segment of knowledge which is created in partners’ portals will be displayed in the cloud. The cloud contains knowledge from portals. Portals and the cloud will be linked by a specific type of connections (pipes), which presents the knowledge to the cloud without copying them. We implement the proposed architecture online to prove its validity. The prototype that we examine has three partners including finance, insurance, and transportation. Each partner creates knowledge by using its portal and saving it in its own knowledge base (KB). Likewise, each partner has an access to other partners’ portals to ask questions or perform inquiries. The answered questions are saved in the KBs and displayed in the cloud. For implementation, we use Joomla as CMS portals, K2 as KB in each portal, Yahoo Pipes as connections between the portals and the cloud. Finally, the cloud is a webpage that displays knowledge from different portals. We demonstrate that the proposed architecture facilitates sharing knowledge among the partners in the VO, and prevents knowledge duplications in different KBs. Moreover, we could move the stored knowledge from KB to another by using backup feature the CMS portal if any partner want to leave or the VO decides to terminate.
The Role of the Glycerophosphocholine Remodelling in Alzheimer’s Disease
Creators: name: P. Blanchard, Alexandre
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Alzheimer’s disease
Aging
Lipid
Lipidomics
Glycerophosphocholine
Mass spectrometry
Bioinformatic
Lipid identification

description: Advances in high performance liquid chromatography-electrospray ionization-mass spectrometry made in proteomics and now applied to the emerging field of lipidomics has enabled the identification of lipid composition at the molecular level. These improvements have given fresh impetus to lipid research. Modulating lipid compositions has been suggested to represent a novel therapeutic target for intervention in Alzheimer’s disease. A better understanding of how metabolic alterations in the lipid landscape alter Alzheimer’s disease prognosis is required to realize this promise. To achieve this goal, further methodological improvement in lipidomic data acquisition and analysis are required as are comprehensive comparative analyses of lipid metabolism at the systems level in clinical samples and mouse models of human neurodegenerative disease. In this thesis, I present two new lipidomic bioinformatic tools Retention Time Standardization and Registration (RTStaR) and Visualization and Phospholipid Identification (VaLID) designed to facilitate analysis of high performance liquid chromatography-electrospray ionization-mass spectrometry lipidomic data. Using these tools and methodologies, I then comparatively profiled the glycerophosphocholine lipidome in the plasma of young adults, cognitively normal elderly with vascular impairment, mild cognitive impairment and late-onset Alzheimer’s disease patients and the entorhinal-hippocampal circuit of late-onset Alzheimer’s disease patients, TgCRND8 human amyloid beta precursor protein transgenic mice (Alzheimer’s disease mouse model), and across the lifespan of NonTg female littermates. Systems-level analyses identified aberrant glycerophosphocholine metabolic pathways systemically perturbed by age, disease, and amyloid beta biogenesis resulting in the regionally-specific accumulation of critical platelet-activating factor and, to a lesser extent, the lysoglycerophosphocholine, metabolites in brain that could be, in part, predicted by changes in plasma. Finally, using proteomic approaches I identified additional changes in lipid metabolic pathways associated with phenoconversion in the TgCRND8 mouse model of Alzheimer’s disease.
L'utilisation des textos entre partenaires amoureux: Une exploration des liens entre interactions par textos et interactions en face-à-face
Creators: name: Schryer, Benoit
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Messagerie texte
Communication médiée par ordinateur
Relations amoureuses
Effets des médias

description: Les partenaires amoureux valorisent particulièrement l’utilisation de la messagerie texte (ou textos) entre eux (Coyne et al., 2011; Pettigrew, 2009). La présente thèse s’intéresse à la façon dont les partenaires amoureux utilisent les textos entre eux en mettant l’accent sur le fait que leurs interactions par textos sont généralement interdépendantes avec leurs interactions en face-à-face (Cardon et al., 2005; Ramirez & Broneck, 2009), traditionnellement reconnues comme étant importantes en relations amoureuses (Andersen et al., 2006; Frisby & Booth-Butterfield, 2012). En considérant notamment la théorie de l’hyperpersonnel (Walther, 1996), les résultats de la présente thèse suggèrent entre autres que les jeunes partenaires amoureux réfléchissent aux effets de leurs textos sur le déroulement de leurs interactions en face-à-face entre eux et qu’ils profitent des textos pour préparer et cadrer leurs interactions en face-à-face à venir.