cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel cancer metabolite-triggered drug delivery
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Stimuli-responsive drug delivery strategies are designed to react to changes in conditions, such as pH or temperature, within the microenvironment of tissues or cells. However, often these triggers are not adequately specific, as the conditions can occur at alternate off-target locations, or the differences between diseased vs. normal states are not sufficiently high. This proposed project will develop a novel drug delivery strategy that will target tumors by specifically responding to lactate, a signature metabolite of cancer and a hallmark of the Warburg effect. The Warburg effect has not yet been exploited in a drug release mechanism, so our proposed drug delivery material will introduce a novel means to deliver and release drug cargo to tumor environments with elevated lactate concentrations, and it is likely to be more specific towards cancer than existing approaches. We hypothesize that hydrogels responsive to the Warburg effect can be created by incorporating specifically-engineered lactate-binding proteins within polymeric matrices. The polymer component has been utilized in molecular imprinting, and the unique metabolite "sensor" will be engineered mutants of a protein with natural binding affinity to lactate. A small library of rationally-designed mutants will be created to obtain binding affinities appropriate for response. The protein and its polymerizable inhibitor will be incorporated into the hydrogel polymer, with interactions between the protein and inhibitor serving as reversible cross-linkers. Competitive binding of this material with the lactate in the microenvironment will result in material swelling and drug release. This proposed work will generate proof-of-concept data for future studies in metabolite-responsive drug therapy. Our aims are to: (1) engineer proteins that will competitively bind the lactate metabolite and its monomer inhibitor; (2) fabricate Warburg effect-responsive protein-polymer hydrogels; and (3) examine the hybrid materials' response to the lactate metabolite and the corresponding drug loading/release.
Nitzschinirmus Mey & Barker 2014
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Nitzschinirmus

description: Status of Nitzschinirmus Mey & Barker, 2014
Molecular data indicate that the type species of Nitzschinirmus Mey & Barker, 2014 is firmly nested within Guimaraesiella (Bush et al. 2015, 2016). Nevertheless, Mey (2017: 91) argues that despite this placement, there “gar nicht zur Debatte stehen kann” (= “can be no debate”) that Nitzschnirmus is a valid genus, and lists it as such in his Appendix III. We disagree with this statement.
The type species of Nitzschinirmus is Nirmus menuraelyrae Coinde, 1859. We agree with Mey & Barker (2014) that this is a morphologically very distinct species. However, apart from the peculiar abdominal chaetotaxy and the sexually dimorphic antennae, there are very few characters that actually separate N. menuraelyrae from other species of Guimaraesiella. We find the genetic placement of this species within Clade A-1 by Bush et al. (2015, 2016: 741; fig. 3a; specimen 129) consistent with other morphological characters. Statistical support for the placement of N. menuraelyrae in this clade is high (Bush et al. 2015, 2016). Whatever the correct generic name for this clade is, N. menuraelyrae belongs within it.
Prior to 2014, the clade of lice to which N. menuraelyrae belongs has been given four different names: Guimaraesiella Eichler, 1949, Xobugirado Eichler, 1949, Allobrueelia Eichler, 1951 [described as new a second time by Eichler (1952)], and Allonirmus Złotorzycka 1964. Gustafsson & Bush (2017: 220–221) considered Xobugirado, Allobrueelia, and Allonirmus to be indistinguishable from Guimaraesiella. Moreover, the type species of Guimaraesiella was included in the phylogeny of Bush et al. (2015, 2016: 741; fig. 3a; specimens 175 and 176), and placed in the same clade as N. menuraelyrae, with high support. In conclusion, the resurrection of Nitzschinirmus from synonymy under Guimaraesiella is unjustified. Furthermore, accepting Nitzschinirmus as a distinct genus would mean that Guimaraesiella, as characterised genetically by Bush et al. (2015, 2016) and morphologically by Gustafsson & Bush (2017), would need to be divided into dozens of small, monotypic genera to avoid paraphyly. Virtually all of these genera would be morphologically indistinguishable from each other, which would substantially hinder future taxonomic work.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 255, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
The Kensington jaunts
Creators: name: Deagler, Michael
Publisher: name: No Publisher Supplied
Year: 2014

description: The Kensington Jaunts is a collection of fifteen linked short stories set in the Kensington section of Philadelphia and the surrounding neighborhoods. It follows a group of violent, inebriated, underemployed, and occasionally criminal young men as they encounter the unintended consequences of addiction, violence, gentrification, and dwindling expectations for the Millennial generation of Americans and the neighborhoods the inhabit.
Insulin-Resistance Polymorphisms, Lifestyle in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This award is to provide me with collaboration through mentored guidance necessary to become an independent academic career as a gene–environmental cancer epidemiologist in the fields of cancer prevention and control research. The overarching goal of my proposed research is to understand the influence of gene–lifestyle interactions on the pathways connecting insulin resistance (IR) and breast cancer among postmenopausal women, a population highly susceptible to breast cancer. Obesity is a well-established risk factor for postmenopausal breast cancer; obesity–insulin connections in particular have gained growing attention over the last decade as potential factors of cancer development. Although IR, obesity status, and the related lifestyle factors for postmenopausal breast cancer are well established, the genetic basis of IR that is associated with breast cancer is largely unknown. In addition, no studies to date have explored the interacting role of obesity status and the lifestyle factors in these pathways among IR-related genetic variants, IR traits (e.g., IR), and postmenopausal breast cancer risk. Further, genome-wide association (GWA) study has become standard for exploring associations between common genetic variants across the genome and cancer. However, the statistical tests applied in GWA studies typically focus on single markers and some generic markers may be missed owing to the strict statistical threshold. I will use a pathway analysis as a complementary approach to identify groups of genes or biologic pathways filled with cancer-related single-nucleotide polymorphisms. Our specific aims are 1) to evaluate the influence of obesity status and lifestyle factors as effect modifiers of the associations among IR genetic variants, IR traits, and breast cancer risk and 2) to perform pathway-based association analysis between IR genes and breast cancer risk. These specific aims will be accomplished by using the existing large cohort data of postmenopausal women from the Women’s Health Initiative Database for Genotypes and Phenotypes Study. Elucidating how obesity and correlated lifestyle factors intermingle with pathways of IR, the relevant genes, and breast cancer may yield new insight into the study of gene–lifestyle interactions. This study will also suggest data on potential genetic targets in clinical trials for cancer prevention and intervention strategies.
The evangelical gender dilemma
Creators: name: Dela George, Danielle S.
Publisher: name: No Publisher Supplied
Year: 2014

description: Because feminism is concerned with equality for men and women and the interrogation of gender as a socially constructed phenomenon, evangelicalism is traditionally viewed a movement counter to feminist viewpoints. Although evangelicalism understands gender as being biblically based on the “creation order,” in terms of separate roles, male headship and women’s submission, the ways in which feminist ideology and evangelicalism interact shows that evangelicalism cannot be easily dismissed as strictly counter to feminist ideas. Changes in gender role ideology show that a significant minority of evangelicals fall somewhere in between a traditional and more egalitarian view of gender roles in the church and home. Exploring gender role ideology in the context of the evangelical movement will show that contradictions within the movement reveal that “ideology and practice do not always correspond” (Colaner 101). Through scholarly research, interviews and personal experience, I will illustrate that the evangelical movement’s engagement with contemporary society—especially since the rise of biblical feminism—has led to a mixture of traditional values and more progressive, liberal views by a small portion of its followers.
Cleopsylla townsendi Rothschild 1914
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Stephanocircidae
Cleopsylla
Cleopsylla townsendi

description: Cleopsylla townsendi Rothschild, 1914
NHM. Peru—Pachacayo. Mammalia—Rodentia—Muridae— Rattus sp. Peru; Chile; Argentina—Catamarca: Humaya, Las Juntas. Mammalia—Rodentia—Cricetidae— Akodon spegazzinii, Phyllotis osilae. Colombetti et al. (2008).
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 244, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Additional file 9: of Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
Creators: name: Oduor, Cliff
name: Kaymaz, Yasin
name: Kiprotich Chelimo
name: Otieno, Juliana
name: OngâEcha, John
name: Moormann, Ann
name: Bailey, Jeffrey
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: ATM and NLK downregulation in BL cell lines. A.) Hierarchical clustering of BL cell lines and germinal center (GC) B cells based on the expression of MYC, NLK and ATM genes. B.) Expression changes of ATM and NLK in BL cell line compared to GC B cells. (PDF 403 kb)
The Developmental Science of Adolescence
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The onset of puberty represents a period of challenges and opportunities for children and society. The emergent field of adolescent neuroscience is making inroads into informing how neural development contributes to emergent vulnerabilities for mental illness, problem behavior, and learning difficulties. Yet, these developmental changes in the adolescent brain also create opportunity—a maturational period of flexibility and potential that can be leveraged by understanding the transactions among multiple levels of influence to promote healthy positive trajectories into and through adulthood. It is becoming increasingly clear that the most promising approaches to successfully leveraging these rapid advances in neuroscience for public good will require a more integrated and interdisciplinary understanding of adolescence. Adolescence encompasses an enormous range of changes—including the pubertal effects on body and brain, the many facets of behavioral, social, emotional and cognitive development during adolescence, and changing economic and cultural influences. Given these complexities, progress in understanding the developmental science of adolescence will require transdisciplinary approaches. This is the primary goal of our project: to advance the Developmental Science of Adolescence. We seek a deeper understanding of how and when these biologically-driven maturational changes interact with the dynamic social world in ways that can increase the potential of youth to become integral, healthy, and productive members of society. Finding answers is of particular importance to California, with implications for the education, health, and social policy of the state’s diverse youth. We propose a two-year planning grant to develop a new multi-campus, interdisciplinary collaboration in order to compete for extramural awards to support an eventual integrative research and training center on the science of adolescent development. Funding agencies increasingly demand an integration of brain development with social and cultural factors critical during the adolescent years (e.g., economic resources, ethnic and cultural diversity, schools and communities), and we are unaware of organized efforts at other institutions designed to meet this challenge. The UC possesses faculty and facilities at multiple campuses that can make it a leader in setting the agenda for the next generation of research in the science of adolescent development and its implications for policy, health, and education.
“The production of a rational Being"
Creators: name: Gatian, Natasha L
Publisher: name: No Publisher Supplied
Year: 2014

description: The eighteenth century saw the emergence of two primary literary forms aimed at influencing public life: the satire and the sentimental novel.  While these two forms pursued similar goals, they were produced separately until Laurence Sterne’s mingling of the two genres in The Life and Opinions of Tristram Shandy, Gentleman.  This text combines two previously gendered genres while also undermining male authority with its narrative false starts and symbolically impotent narrator.  It also displays satirical and sentimental impulses with the character parson Yorick, who embodies both the Quixote figure and the philosopher-physician who “heals” him.  Sterne’s collapsing of these gender and generic boundaries, I argue, would open a discursive space for women to enter the literary world as satirists, as this study will demonstrate using works by Charlotte Lennox and Frances Burney.  Lennox’s The Female Quixote, which came before Sterne’s novel, will be considered for its satire of female readers of romances, while Burney’s play The Witlings will show how women engaged in satiric regulation of the public sphere post-Tristram Shandy.  Sterne’s radical challenge to the male institutions of satire and the realistic novel, I argue, allowed women to engage in the unprecedented production of satirical texts that tackle public as well as domestic concerns.
Ptilononirmus australis Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Ptilononirmus
Ptilononirmus australis

description: Ptilononirmus australis Mey, 2017
Ptilononirmus australis Mey, 2017: 100, figs 4, 13–18, pl. II: figs 3–4. S pecies inquirenda.
Type host: Scenopoeetes dentirostris (E.P. Ramsay, 1876) —tooth-billed bowerbird.
Type locality: Queensland, Australia.
Remarks. As discussed above, under the genus Ptilononirmus, P. australis needs to be redescribed to establish it correct specific status.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 257, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
Craneopsylla minerva subsp. minerva Rothschild 1903
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Stephanocircidae
Craneopsylla
Craneopsylla minerva
Craneopsylla minerva minerva (rothschild, 1903)

description: Craneopsylla minerva minerva (Rothschild, 1903)
NHM. Paraguay—Sapucay. Mammalia—Chiroptera—Phyllostomidae— Chrotopterus auritus. Didelphimorphia— Didelphidae— Didelphys aurita. Brazil; Chile; Ecuador; Paraguay; Peru; Uruguay; Venezuela; Argentina—Buenos Aires: Delta del Paraná. Catamarca: Otro Cerro. Jujuy: Cerro El Morado, Cuesta del Hurón, La Quiaca, San Antonio, Santa Catalina, Valle Grande, Villa Carolina, Río Lavallen. Mendoza. Río Negro. Salta: Orán. Tucumán: Dique San Ignacio, La Cocha, Río Grande, Tafi Viejo. Mammalia—Didelphimorphia—Didelphidae— Lutreolina crassicaudata, Thylamys cf. cinderella, Thylamys cf. sponsorius, Thylamys pusillus. Rodentia—Caviidae— Galea musteloides. Cricetidae— Akodon dolores, Akodon spegazzinii, Deltamys kempi, Graomys griseoflavus, Holochilus vulpinus, Oligoryzomys xanthopygus, Oxymycterus rufus, Scapteromys aquaticus. Lareschi et al. (2010), López Berrizbeitia et al. (2013).
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 244, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Dasybasis senilis Philippi
Creators: name: González, Christian R.
name: Brevis, Karina
name: Miranda, Carmen
name: Sotomayor, Arlen
Publisher: name: Zenodo
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tabanidae
Dasybasis
Dasybasis senilis

description: Dasybasis senilis (Philippi)
Mandibles: (Fig. 1) Total mean length = 0.330 mm. Greatest mean width 0.019 mm. Medial margin with scarcely curved, pointed and with triangular teeth; lateral margin without teeth. Apex rounded, without apical teeth. Ventral and dorsal surface bare.
Lacinia: (Fig. 2) Total mean length = 0.29 mm. Greatest mean width 0.005 mm. Apex of the dorsal surface with 2–9 teeth, flattened apically and more erect proximally, retrorse. Dorsolateral surface with short, uniform and sparse micropilosity. Dorsomedial surface, distal to the apical teeth, bare. Ventral surface bare.
Labrum: (Fig. 3) Total mean length = 0.283 mm. Greatest mean width 0.037 mm. Apex blunt. Dorsal surface with abundant and short microtrichiae; medially swollen, convex and bare. Apex with erect and triangular apical microteeth and circular depressions. Ventral surface without micropilosity.
Hypopharynx: (Fig. 4) Total mean length = 0.22 mm. Greatest mean width 0.015 mm. Apex acute. Without micropilosity or other ornamentation. Dorsomedial surface smooth, bare; salivary duct opening in the apex. Ventral surface rugose, bare.
description: Published as part of González, Christian R., Brevis, Karina, Miranda, Carmen & Sotomayor, Arlen, 2005, Comparative study of mouthparts of the female of two species of Dasybasis Macquart from Chile (Diptera: Tabanidae), pp. 35-41 in Zootaxa 1058 on pages 37-38, DOI: 10.5281/zenodo.273250
The local adaptation of the circadian clock's temperature compensation in Neurospora
Creators: name: Hozier, James
Publisher: name: No Publisher Supplied
Year: 2014

description: In the current study, we have tested the hypothesis that temperature compensation (TC) of the circadian clock plays a role in local adaptation. To test this hypothesis, we chose strains of Neurospora collected from different latitudes; Alaska (high) and Ivory Coast (low). To examine the molecular oscillator of these selected strains, we transformed the natural strains with a translational luciferase reporter of the key clock gene FREQUENCY (FRQ). To examine the developmental overt rhythm, we used the inverted race tube assay. Q10 values of the molecular periods and the developmental periods of each strain have been calculated, and used as a quantitative measure of TC. Our data suggest that the molecular oscillators of natural strains collected from different latitudes do not differ from one another, and their Q10 values are relatively similar to each other. However, we found that the developmental overt rhythms have different period and Q10 values and a period among the strains studied. The periods and Q10 values of developmental rhythm are also more variable when compared to those of the molecular rhythm. Taken our results together, we concluded that 1) TC plays a role in adaptation, 2) the adaptation occurred at either the output of the clock or at the coupling mechanism between the oscillator, and 3) the adaptation occurred at the developmental rhythm rather than the molecular oscillator
Political emotions
Creators: name: Johnston, Gabriel
Publisher: name: No Publisher Supplied
Year: 2014

description: Recent research has demonstrated the undeniable influence of emotion on political  decision making and voter choice. Research on negative campaigning has grown in the  past decade, but a recent meta-analysis reached no conclusion about its effectiveness  (Lau & Rovner, 2009). There is still debate in the literature as to whether the dimensional  emotion perspective or the discrete emotion perspective is superior, and consequently  few studies have examined whether discrete emotions (in this case anger and contempt)  have differential impacts on voters’ perceptions of candidates. Although anger and  contempt are both negatively valenced emotions related to interpersonal conflict, they  differ in both social function and prototypical behaviors (Fischer & Roseman, 200&). This  study tested the differential impacts of anger and contempt on voters’ reactions to  presidential candidates by having three groups of participants watch the second presidential debate between Barack Obama and Mitt Romney and indicate each time they either (1) perceive Obama or Romney to express anger or contempt or (2) feel anger or contempt toward Obama or Romney or (3) have favorable or unfavorable impressions of Obama or Romney. Pre- and post-debate questionnaires measured participants’ perceptions of the candidates and participants’ favorability towards the candidates. Multiple regression models tested the effects of anger and contempt on perceptions of presidential candidates and feelings of favorability toward those candidates. Feelings of anger and contempt inconsistently predicted a decrease in favorability, although feelings of anger better predicted negative perceptions than feelings of contempt. Expressions of anger by the candidates were overall related to a decrease in positive perceptions toward the expressing candidate and, in some cases, a decrease in negative perceptions of the opposing candidate. However, expressions of both anger and contempt by the candidates were also related to an increase in negative perceptions of the opposing candidate, although expressions of contempt had a stronger relationship with increased negative perceptions. Overall, anger and contempt were shown to have differential impacts on perceptions and favorability toward presidential candidates.
Fight flight freeze
Creators: name: Kennedy, Sarah
Publisher: name: No Publisher Supplied
Year: 2014

description: Fight Flight Freeze is a collection of nonfiction essays that blend personal narrative with research and contemplation. At their core, these essays are driven by questions about how we shape and define our lives. Through a series of encounters—with a libertarian survivalist and conspiracy theorist, with the wealthy patrons at Saks Fifth Avenue, with competitive stone-skippers, with Mormon missionaries, with the decaying town of my mother's youth—Fight Flight Freeze seeks answers to the question, "How do we decide how to live?" While the essays are rarely overtly political, they reflect the questions and anxieties aroused by coming into adulthood in the decade since 9/11. I ask how we shape our individual lives in relation to those around us—both loved ones and strangers, communities and governments, and the generations that have come before.
Olivinirmus agadirensis Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Olivinirmus
Olivinirmus agadirensis

description: Olivinirmus agadirensis Mey, 2017
Olivinirmus agadirensis Mey, 2017: 112, fig. 35, pl. IV: figs 3–4. Species inquirenda
Type host: Pica pica mauritanica Malherbe, 1845 —Eurasian magpie.
Type locality: Agadir, Morocco.
Remarks. Olivinirmus agadirensis Mey, 2017 is a member of the Ol. glandarii species group (sensu Gustafsson & Bush 2017). At present, it is not possible to clearly distinguish Ol. agadirensis from Ol. glandarii (Denny, 1842), as all characters purporting to separate them are either in the pigmentation patterns or variable within species, with the exception of the shape of the mesosome. Considering that the mesosome of Ol. glandarii illustrated by Gustafsson & Bush (2017: fig. 331) is more similar to that of Mey’s (2017: fig. 35b) for Ol. agadirensis than to Mey’s (2017: fig. 35a) illustration of Ol. glandarii, it is uncertain whether this character can separate the two species.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 258, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
Corruption in Africa
Creators: name: Kelly, Robert M.
Publisher: name: No Publisher Supplied
Year: 2014

description: An examination into corruption within Africa reveals that certain factors make it different than those shown in Europe, and particularly those countries that rely on one or two major sources of natural resources such as Nigeria and the Democratic Republic of the Congo, tend to exacerbate corruption within those nations. There are several solutions, such as political which have the potential to reduce corruption, however economic development and the creation of a stable middle class holds the best promise to mitigate the worst effects.
Olivinirmus amamiensis Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Olivinirmus
Olivinirmus amamiensis

description: Olivinirmus amamiensis Mey, 2017
Olivinirmus amamiensis Mey, 2197: 112, fig. 28, pl. IV: fig. 2.
Type host: Garrulus lidthi Bonaparte, 1850—Amami jay.
Type locality: Amami Oshima Island, Japan.
Remarks. Olivinirmus amamiensis Mey, 2017 is known from females only, and the description includes a single illustration of the lateral tergopleurites. Thus, it cannot be placed in any of the species groups defined by Gustafsson & Bush (2017). Mey (2017: 112) compares Ol. amamiensis with Ol. Glandarii and Ol. perisoreus, both of which belong to the Ol. Glandarii species group. Although the differences between Ol. amamiensis and Ol. Glandarii, based on Mey’s (2017) descriptions, seem tenuous, we examined additional material from the same host species and agree that they are two different species. The material we have studied belongs in the Ol. Glandarii species group.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 258, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
Olivinirmus borneensis Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Olivinirmus
Olivinirmus borneensis

description: Olivinirmus borneensis Mey, 2017
Olivinirmus borneensis Mey, 2017: 106, figs 24, 31–32, pl. III: figs 2–3.
Guimaraesiella borneensis (Mey, 2017). New combination.
Type host: Platysmurus leucopterus aterrimus (Temminck, 1824) —Bornean black magpie.
Type locality: Trusan, Borneo.
Remarks. Olivinirmus borneensis Mey, 2017 has male genitalia that are unlike those of all other known species of Olivinirmus, but are typical of many species of Guimaraesiella. The illustration of the tergopleurites and the habitus photograph support the placement of this species in Guimaraesiella. However, the lack of illustrated details of the male genitalia (Mey 2017: fig. 32, not 22 as stated in the description on page 108) make this placement somewhat tentative. Mey’s (2017: fig. 24) illustration of the lateral tergopleurites depicts an accessory postspiracular seta (aps) on segment V, which is standard in most species of Guimaraesiella (see Gustafsson & Bush 2017: table 10). This species needs to be thoroughly redescribed, so that its correct generic position can be established. We therefore tentatively place Ol. borneensis in Guimaraesiella new combination, making this taxon the first Guimaraesiella known to parasitize corvid hosts.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 258, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
Craneopsylla minerva subsp. wolffhuegeli Rothschild 1909
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Stephanocircidae
Craneopsylla
Craneopsylla minerva
Craneopsylla minerva wolffhuegeli (rothschild, 1909)

description: Craneopsylla minerva wolffhuegeli (Rothschild, 1909)
NHM. Argentina—Buenos Aires: Porvenir, Estancia La Daniela. Mammalia—Didelphimorphia—Didelphidae— Lutreolina crassicaudata. Brazil; Chile; Argentina—Buenos Aires: Ajo, Bonifacio, Chivilcoy, Ramallo. Catamarca. Chubut: Bahía Cracker, Cabo Raso, Carhué Niyeu, Estancia Los Nogales, Isla Escondida, Lago Blanco, Puerto Lobos, Puerto Piojo. Córdoba: Córdoba, Notinger, Totoral. La Pampa. Mendoza: La Paz, San Rafael. Neuquén: Neuquén. Río Negro: Pilcañeu. Salta: Piquirenda Viejo, 12.6 km al W. El Quebrachal, J.V. González. Santa Cruz: Ea. Cerro Ventana, Ea. La Ensenada. Santa Fe: Las Rosas. Santiago del Estero: El Quemado, Las Carpas. Tucumán. Tierra del Fuego Antártida e Islas del Atlántico Sur: Ea. San Martín. Mammalia. Vespertilionidae— Myotis nigricans (accidental host). Didelphimorphia—Didelphidae— Didelphis sp., Didelphis albiventris. Rodentia—Caviidae— Microcavia australis. Cricetidae— Abrothrix hirta, Abrothrix olivacea, Akodon azarae, Akodon dolores, Akodon iniscatus, Calomys musculinus, Eligmodontia typus, Graomys griseoflavus, Holochilus vulpinus, Loxodontomys micropus, Oligoryzomys sp. Phyllotis xanthopygus, Reithrodon auritus, Scapteromys aquaticus. Muridae— Rattus rattus. Autino et al. (2009), Sanchez et al. (2009), Sanchez & Lareschi (2013; 2014).
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 244, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Additional file 1: of Impaired Ciliogenesis in differentiating human bronchial epithelia exposed to non-Cytotoxic doses of multi-walled carbon Nanotubes
Creators: name: Snyder, Ryan
name: Salik Hussain
name: Tucker, Charles
name: Randell, Scott
name: Garantziotis, Stavros
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Bronchoscopy procedure and the characterization of the nanomaterials. (DOCX 680 kb)
The impact of trust in health care
Creators: name: Kelly, Caitlin Shea
Publisher: name: No Publisher Supplied
Year: 2014

description: Type 2 diabetes is a chronic disease that requires individuals to assume the primary responsibility of self-managing their health behaviors. Many professionals may be involved in promoting positive health behaviors among patients with diabetes, but how patients’ relationships with their healthcare providers impact their self-management behaviors has not yet fully been explored. Are efforts by healthcare providers to impart good self-management behaviors effective for patients with type 2 diabetes? The current study aimed to contribute to this area of the literature by exploring which providers have the strongest associations with patients’ self-management behaviors, and whether trust influences this association. Using self-report questionnaires and an in-person interview, 59 middle-aged and older adults with type 2 diabetes answered questions regarding provider use, trust in these providers, and health behaviors and clinical health outcomes. The results from linear regression analyses revealed that patients’ trust in their providers was a key factor in moderating the association between seeing a primary care provider (e.g. family practitioners), seeing an endocrinologist, or primary health insurer type and lower average fasting blood sugar and Hemoglobin A1c levels. The results of this study suggest that important diabetes health outcomes (i.e. blood glucose values) are related to the patient-provider relationship; health behaviors (e.g., exercise or diet), however, are not influenced by this relationship. The results from this study may provide some insight into how providers influence different self-management behaviors and health outcomes in patients with type 2 diabetes and how trust is a key aspect of the patient-provider relationship.
Characterization of anxiolytic compounds from Annona muricata leaf extract
Creators: name: Lallier, Brian
Publisher: name: No Publisher Supplied
Year: 2014

description: Annona muricata is a perennial tree found in most tropical areas of the world, including Western Africa, Central and South America and Southeast Asia. It has been used around the world medicinally by several cultures. Some of these cultures use A. muricata as an anxiolytic tea given to unruly patients. Traditional anxiolytic uses of Annona muricata in medicine have long existed, without knowledge of the active compound or compounds. We aim to scientifically support and extend these traditional uses by characterizing the bioactive compound(s) within the leaf extract. The active structures can then be modified to provide potentially new classes of active drugs. The anti-anxiety effects of A. muricata seen in traditional medicine were characterized by using a set of widely-accepted behavioral models of anxiolytic effects in mice. Partial phytochemical profiling done through ultra-high performance liquid chromatography (UHPLC) and gas chromatography-mass spectrometry (GC-MS) has identified a list of compounds that comprise the different fractions of the leaf extract. Through the mouse behavioral investigations, an active fraction has been determined to have a sedative effect, and through a dose-response study, an anxiolytic-like activity has been determined for the same fraction. Further fractionation of the extract and subsequent mouse behavioral studies have resulted in the discovery of smaller groups of potentially active compounds that can be fully profiled and modeled using Computer-Aided Drug Discovery (CADD). The use of mouse behavioral models of anxiolytic effects and the chromatographic analysis of the leaf extract allowed the identification of active fractions in aqueous extract. Both sedative and anxiolytic-like concentrations of the extract’s polar components were demonstrated, and further profiled. The profiled chemical compounds can be modeled to better suggest which compounds may provide the bioactive effects in vivo.
Dasybasis testaceomaculata Macquart
Creators: name: González, Christian R.
name: Brevis, Karina
name: Miranda, Carmen
name: Sotomayor, Arlen
Publisher: name: Zenodo
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tabanidae
Dasybasis
Dasybasis testaceomaculata

description: Dasybasis testaceomaculata (Macquart)
Mandibles: (Fig. 5) Total mean length = 0.345 mm. Greatest mean width 0.021 mm. Medial margin curved, pointed and with triangular teeth; lateral margin without teeth. Apex rounded, with apical pointed teeth and without triangular teeth. Ventral and dorsal surface bare.
Lacinia: (Fig. 6) Total mean length = 0.31 mm. Greatest mean width 0.006 mm. Apex of the dorsal surface with 2–8 teeth, flattened apically and more erect proximally, retrorse. Dorsolateral surface with long, not uniform and abundant micropilosity. Dorsomedial surface, distal to the apical teeth, bare. Ventral surface bare.
Labrum: (Fig. 7) Total mean length = 0.294 mm. Greatest mean width 0.041 mm. Apex blunt. Dorsal surface with sparse, short microtrichiae; median surface swollen, bare. Apex with semi erect and triangular apical microteeth and circular depressions. Ventral surface without micropilosity.
Hypopharynx: (Fig. 8) Total mean length = 0.26 mm. Greatest mean width 0.018 mm. Apex acute. Without micropilosity or other ornamentation. Dorsomedial surface smooth, bare; salivary duct opening in the apex. Ventral surface rugose, bare.
description: Published as part of González, Christian R., Brevis, Karina, Miranda, Carmen & Sotomayor, Arlen, 2005, Comparative study of mouthparts of the female of two species of Dasybasis Macquart from Chile (Diptera: Tabanidae), pp. 35-41 in Zootaxa 1058 on page 38, DOI: 10.5281/zenodo.273250
Inhibition of Breast Cancer Cell Invasion by Natural Indoles
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The metastatic spread of breast cancers accounts for the lethality of the disease. Metastatic cancers are frequently resistant to therapy and therefore there is a great need to develop new therapeutics that target the spread of both estrogen-dependent and estrogen-independent breast tumors. A promising new anti-breast cancer strategy is to develop the use of phytochemicals as natural chemotherapeutic or preventative agents. One potential source to uncover new types of therapeutics is from dietary plants because many phytochemicals, biologically active compounds in plants, have anti-carcinogenic properties. Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), naturally occurring in Brassica vegetables such as broccoli and cabbage, have striking growth arrest properties in estrogen-dependent and independent breast tumors. Most importantly, these indoles prevent the metastases of breast cancer cells injected into mice, and inhibit invasion through synthetic membranes.

 I will investigate the molecular mechanism of indole-regulated inhibition of invasion, since this process is critical to metastasis. I hypothesize that I3C and DIM exert their anti-invasive actions by inhibiting the production of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix. MMP-2 and MMP-9, which are commonly present at higher levels in patients with breast cancer, break down the main constituent of the extracellular membrane, and have been directly implicated in tumor metastasis. My preliminary data shows that I3C decreases the expression of the MMP-2 and MMP-9 genes. Thus, the objective of this proposal is to investigate the indole-regulated cellular pathways that control MMP-2 and MMP-9 and breast cancer cell invasion.

 The first aim of these studies is to establish that the extracellular secretion of MMP-2 and MMP-9 decreases in both poorly and highly invasive breast cancer cells. Then, I will functionally test that the MMPs are within the indole-regulated pathways, by reversing their decreased levels. This will be accomplished by the introducing of additional copies of MMP-2 and MMP-9 genes into breast cancer cells and determining whether indoles can no longer prevent invasion. I will then determine the precise DNA sequences and DNA-binding factors that cause MMP-2 and MMP-9 gene synthesis to be down-regulated by indoles.

 The results of these experiments will provide key insights into the molecular mechanism by which natural indoles prevent cancer cell metastasis. This study represents a novel application of phytochemical nutrients in the control of tumor dissemination.
Nonnapsylla rothschildi Wagner 1938
Creators: name: Lareschi, Marcela
name: Sanchez, Juliana
name: Autino, Analía
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Siphonaptera
Stephanocircidae
Nonnapsylla
Nonnapsylla rothschildi

description: Nonnapsylla rothschildi Wagner, 1938
ZMB. Bolivia—Río Yapacani, Santa Cruz de la Sierra. Aves—Cuculiformes—Opisthocomidae— Opisthocomus hoazin. Bolivia; Chile; Peru; Argentina—Jujuy: Cuesta del Hurón, Curques, Santa Catalina, Susques. Mammalia— Rodentia—Caviidae— Galea musteloides. Cricetidae— Eligmodontia puerulus, Phyllotis xanthopygus. Octodontidae— Octodontomys gliroides. Lareschi et al. (2011). These authors put into synonymy the subspecies rothschildi and wagneri.
description: Published as part of Lareschi, Marcela, Sanchez, Juliana & Autino, Analía, 2016, A review of the fleas (Insecta: Siphonaptera) from Argentina, pp. 239-258 in Zootaxa 4103 (3) on page 245, DOI: 10.11646/zootaxa.4103.3.3, http://zenodo.org/record/262230
Additional file 1: of The role of controllable lifestyle in the choice of specialisation among Hungarian medical doctors
Creators: name: Girasek, Edmond
name: Szócska, Miklós
name: Kovács, Eszter
name: Gaál, Péter
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Human Resource Research in Healthcare – Questionnaire. (PDF 224 kb)
Changes in BMP and EGFR signaling components underlie the evolution of Drosophila eggshell morphologies
Creators: name: Niepielko, Matthew Gene
Publisher: name: No Publisher Supplied
Year: 2014

description: A fundamental requirement for understanding the evolution of tissue  morphogenesis involves exploring underlying changes in cell signaling amongst species.  We used the magnificent diversity of Drosophila eggshell morphologies to investigate  mechanisms guiding morphological variation. Drosophila eggshell structures, including  the dorsal appendages (DAs) and the dorsal ridge (DR), are formed during oogenesis  when a 2D monolayer of follicle cells (FCs) overlying the oocyte is instructed by  numerous cell signaling pathways to form the eggshell. Here, we focus on the bone  morphogenetic protein (BMP) signaling in reference to DAs formation, and the epidermal  growth factor receptor (EGFR) in reference to DR formation. BMP signaling in the FCs  is initiated when the anteriorly secreted transforming growth factor-β-like  Decepentaplegic (DPP) activates a uniform and then patterned type I BMP receptor  Thickveins (TKV). We found that the pattern of BMP signaling is dynamic and spatially  diverse in species with different DAs morphologies. Using computational modeling and  experimental validation, we found that qualitative and quantitative changes in TKV can  account for different BMP signaling outputs across species. The DR is a lumen-like  structure along the dorsal-most side on eggshells of numerous species and absent from D.  melanogaster eggshells. We developed a binary matrix to analyze 180 2D expression  patterns of a family of structural proteins, the Chorion proteins, in species with and  without a DR and associate DR patterns to domains of known regulation. The DR  domain clusters with EGFR regulated domains and thus, we focused on EGFR and DR  formation. EGFR activation begins when the transforming growth factor-α-like ligand,  Gurken (GRK), is secreted from the oocyte and creates a dorsal-ventral activation  gradient. We found that DR morphologies correlate with EGFR signaling and GRK  patterns in the DR domain. In the DR species D. willistoni, we successfully perturbed  EGFR signaling and DR formation by genetically perturbing GRK levels. Expression of  D. willistoni GRK (wGRK) in D. melanogaster rescues the GRK null phenotype and in  some cases, wGRK is sufficient to produce a ridge-like structure on D. melanogaster  eggshells. Our results support the idea that changes in major components of  developmental pathways underlie the evolution of morphologies.
Olivinirmus cittaphilus Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Olivinirmus
Olivinirmus cittaphilus

description: Olivinirmus cittaphilus Mey, 2017
Olivinirmus cittaphilus Mey, 2017: 110, figs 27, 34, pl. IV: fig. 1.
Type host: Dendrocitta cinerascens Sharpe, 1879 —Bornean treepie.
Type locality: Kina Balu, North Bornea.
Remarks. Olivinirmus cittaphilus Mey, 2017 is a member of the Ol. meinertzhageni species group (sensu Gustafsson & Bush 2017). Mey (2017) compared his new species with Ol. meinertzhageni, and the characters given appear to separate these two species well.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 258, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680