cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Asymptotic base loci via Okounkov bodies
Creators: name: Choi, Sung Rak
name: Hyun, Yoonsuk
name: Park, Jinhyung
name: Won, Joonyeong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: An Okounkov body is a convex subset of Euclidean space associated to a divisor on a smooth projective variety with respect to an admissible flag. In this paper, we recover the asymptotic base loci from the Okounkov bodies by studying various asymptotic invariants such as the asymptotic valuations and the moving Seshadri constants. Consequently, we obtain the nefness and ampleness criteria of divisors in terms of the Okounkov bodies. Furthermore, we compute the divisorial Zariski decomposition by the Okounkov bodies, and find upper and lower bounds for moving Seshadri constants given by the size of simplexes contained in the Okounkov bodies.
description: 17 pages. Final version
Clinical Implementation of Germ Line Cancer Pharmacogenetic Variants During the Next-Generation Sequencing Era
Creators: name: Patel, J. N.
name: Gillis, N. K.
name: Innocenti, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Over 100 FDA-approved medications include pharmacogenetic biomarkers in the drug label, many with cancer indications referencing germline DNA variations. With the advent of next-generation sequencing (NGS) and its rapidly increasing uptake into cancer research and clinical practice, an enormous amount of data to inform documented gene-drug associations will be collected, which must be exploited to optimize patient benefit. This state-of-the-art article focuses on the implementation of germline cancer pharmacogenetics into clinical practice. Specifically, it discusses the importance of germline variation in cancer and the role of NGS in pharmacogenetic discovery and implementation. In the context of a scenario where massive NGS-based genetic information will be increasingly available to health stakeholders, this review explores the ongoing debate over the threshold of evidence necessary for implementation, provides an overview of recommendations in cancer by professional organizations and regulatory bodies, discusses limitations of current guidelines and strategies to improve third-party coverage.
Pictorial depiction of stability measurement via centrifugation, and droplet size measurements using optical light microscopy from Investigation of the formation mechanisms in high-internal phase Pickering emulsions stabilized by cellulose nanocrystals
Creators: name: Chuanwei Miao
name: Tayebi, Mani
name: Wadood Y. Hamad
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Medium and high internal phase Pickering emulsions stabilized by cellulose nanocrystals (CNC) have been prepared and the effects of CNC concentration and type of oil phase on the properties of emulsions were studied. The maximum oil phase volume that can be stabilized by CNC is 87% when the CNC concentration is 0.6 wt.%, and slightly decreases to 83% when the CNC concentration is increased to 1.2 wt.% or higher. In addition, the oil droplets stabilized with 0.6 wt.% CNC suspensions have a larger size than those stabilized with higher concentration CNC suspensions. As evidenced by the change in oil droplet morphology and size, two different emulsion formation mechanisms are proposed. For CNC concentration at 0.6 wt.%, the extra oil added into the emulsion is accommodated by expansion of oil droplets size, whereas for CNC concentrations 1.2 wt.% and higher, the oil is stabilized mainly by formation of new oil droplets.This article is part of a discussion meeting issue ‘New horizons for cellulose nanotechnology'.
title: Clinical Utility of Cardiovascular Magnetic Resonance in Hypertrophic Cardiomyopathy
Creators: name: Affes, Meriem
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: MR
subject: Imaging sequences
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To remind cardiac MR sequences required for hypertrophic cardiomyopathy (HCM) assessment To be able to identify HCM phenotypes To recognize differential diagnosis. To focus on the MRI prognosis signs and on HCM complications To Provide a standard...
title: Brain lesions with annular enhancement on MRI: how to untie the diagnostic line
Creators: name: azouazi, hajar
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: CT
subject: MR
subject: MR-Diffusion/Perfusion
subject: Imaging sequences
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To show the main etiologies that manifest them selves on MRI as a ring enhacing ring brain lesion in our region To explain the argument that make one diagnosis prevail over anothe by illustrating each etiologie with images from the...
National Survey of Solidarity and Voluntary Action - ENSAV 2021
Creators: name: CEMEX
name: Centro De Investigación Y Estudios Sobre Sociedad Civil (CIESC)
name: Citibanamex
name: Fundación FEMSA
name: Fundación Kaluz
name: De Piedad, The Nacional Monte
Publisher: name: Roper Center for Public Opinion Research
Year: 2023

description: Service actions without payment (26); beneficiaries of service/volunteer work (25); frequency of service/volunteer work (25); effect of coronavirus (COVID-19) pandemic on service activities/donations (26); duration of service/volunteer work (25); performed service/volunteered in the last month (25); organization/location of service (25); impetus for becoming involved in service (1); reasons for performing service (2); people in respondent’s immediately family in service to others (6); have invited others to be in service to others (1); propensity to act in service (4); group identity (3); donation in money and kind in the last year (8); has received support in time or kind from non-relatives or non-governmental organization (3); personal financial situation compared to last year (1); service activities at place of work (5); online giving (2).
Supplementary Material from A random-matrix theory of the number sense.
Creators: name: T. Hannagan
name: A. Nieder
name: P. Viswanathan
name: S. Dehaene
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Methods and analyses. Supplementary Notes 1 to 11; Supplementary Figures 1 to 5; Supplementary Tables 1 to 3; Supplementary References
(400917) Henry T[hwaites] Palmer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Z boson pole mass at two-loop order in the pure MS-bar scheme
Creators: name: Martin, Stephen P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I obtain the complex pole squared mass of the Z boson at full two-loop order in the Standard Model in the pure MS-bar renormalization scheme. The input parameters are the running gauge couplings, the top-quark Yukawa coupling, the Higgs self-coupling, and the vacuum expectation value that minimizes the Landau gauge effective potential. The effects of non-zero Goldstone boson mass are resummed. Within a reasonable range of renormalization scale choices, the scale dependence of the computed pole mass is found to be comparable to the current experimental uncertainty, but the true theoretical error is likely somewhat larger.
description: 15 pages. arXiv admin note: text overlap with arXiv:1503.03782
title: Covered stent-graft repair of hepatic artery pseudoaneurysm- A flow preserving non-surgical technique with review of literature.
Creators: name: Israr, Amrin
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Emergency
subject: Interventional vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: Arterial access
subject: Stents
subject: Technical aspects
subject: Aneurysms
subject: Embolism / Thrombosis

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Pseudoaneurysms (PSA) of hepatic artery are rare complications usually secondary to iatrogenic causes or inflammatory diseases. 1,2 Among the iatrogenic causes pancreatico-duodenectomy (PD) followed by cholecystectomy are the commonest cases of...
Erlotinib in African Americans With Advanced Non–Small Cell Lung Cancer: A Prospective Randomized Study With Genetic and Pharmacokinetic Analyses
Creators: name: Papp, A.
name: Gao, Y.
name: Wei, L.
name: Li, J.
name: Wang, D.
name: Socinski, M. A.
name: Aimiuwu, J.
name: Hicks, W. J.
name: Zhao, W.
name: Otterson, G. A.
name: Blachly, J. S.
name: Stinchcombe, T. E.
name: Poi, M.
name: Villalona-Calero, M. A.
name: Schaaf, L. J.
name: Starrett, S. L.
name: Phelps, M. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Prospective studies focusing on EGFR inhibitors in African Americans with NSCLC have not been previously performed. In this phase II randomized study, 55 African Americans with NSCLC received erlotinib 150mg/day or a body weight adjusted dose with subsequent escalations to the maximum allowable, 200mg/day, to achieve rash. Erlotinib and OSI-420 exposures were lower compared to previous reports, consistent with CYP3A pharmacogenetics implying higher metabolic activity. Tumor genetics revealed only two EGFR mutations, EGFR amplification in 17/47 samples, 8 KRAS mutations and 5 EML4-ALK translocations. Although absence of rash was associated with shorter time to progression (TTP), disease control rate, TTP, and 1-year survival were not different between the two dose groups, indicating the dose-to-rash strategy failed to increase clinical benefit. Observed low incidence of toxicity and low erlotinib exposure suggest standardized and maximum allowable dosing may be suboptimal in African Americans.
title: Contribution of CT in emergency occlusive syndromes, based on a literature review of 415 cases
Creators: name: El Ouazzani, Lamiaa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: CT
subject: Diagnostic procedure
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Intestinal obstruction is a syndrome defined by an impediment to the aboral progression of intestinal contents by mechanical obstruction or by failure of intestinal muscle activity. It represents 10% of acute abdominal pain in adults. Small bowel...
Dental plaque and gingival bleeding in adolescents with juvenile idiopathic arthritis and controls: a multilevel analysis
Creators: name: Gil, Elisabeth Grut
name: Åstrøm, Anne Nordrehaug
name: Lie, Stein Atle
name: Rygg, Marite
name: Fischer, Johannes
name: Rosén, Annika
name: Bletsa, Athanasia
name: Luukko, Keijo
name: Shi, Xie-Qi
name: Halbig, Josefine
name: Frid, Paula
name: Cetrelli, Lena
name: Tylleskär, Karin
name: Rosendahl, Karen
name: Skeie, Marit Slåttelid
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: To explore whether plaque and gingival bleeding are more frequently experienced by adolescents with juvenile idiopathic arthritis (JIA) compared to matched controls without JIA; explore whether surface- and site-specific periodontal outcomes vary between the two groups; and for participants with JIA, investigate associations between disease-specific features and periodontal outcomes. In this comparative cross-sectional study, selected surfaces, and sites of index teeth in 10–16-year-olds with JIA and matched controls were examined by modified versions of Simplified Oral Hygiene Index (OHI-S) and Gingival Bleeding Index (GBI). Mixed-effects logistic regressions, reporting odds ratios (OR) with 95% confidence interval (CI), were applied. Intra-class correlation coefficients (ICCs) were calculated to quantify the degree of dependency of measures within the same individual. 144 and 159 adolescents with JIA were evaluated according to OHI-S and GBI; corresponding numbers of controls were 154 and 161. Plaque and gingival bleeding were more frequent in individuals with JIA than controls. Adjusted analyses showed association between JIA status and OHI-S > 0 (OR = 2.33, 95% CI: 1.47 − 3.67, ICC = 0.45) and GBI > 0 (OR = 1.54, 95% CI: 1.10 − 2.16, ICC = 0.41 and 0.30). Surface-specific distribution of plaque varied among the two groups. Our results highlight the importance of increased awareness of oral health care in patients with JIA and that surface- and site-specific differences in periodontal outcomes exist between individuals with JIA and controls. Few JIA disease-specific variables associated with plaque or gingival bleeding.
Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid–Mediated Troglitazone Hepatotoxicity
Creators: name: Watkins, P. B.
name: Woodhead, J. L.
name: Yang, K.
name: Brouwer, K. L.R.
name: Howell, B. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Troglitazone (TGZ) caused delayed, life-threatening drug-induced liver injury (DILI) in some patients, but was not hepatotoxic in rats. This study investigated altered bile acid (BA) homeostasis as a mechanism of TGZ hepatotoxicity using a systems pharmacology model incorporating drug/metabolite disposition, BA physiology/pathophysiology, hepatocyte life cycle, and liver injury biomarkers. In the simulated human population, TGZ (200–600mg/day×6months) resulted in delayed increases in serum ALT>3× ULN in 0.3–5.1% of the population with concomitant bilirubin elevations>2× ULN in 0.3–3.6%. In contrast, pioglitazone (15–45mg/day×6months) did not elicit hepatotoxicity, consistent with clinical data. TGZ was not hepatotoxic in the simulated rat population. In summary, mechanistic modeling based only on BA effects accurately predicted the incidence, delayed presentation, and species differences in TGZ hepatotoxicity, and the relative liver safety of pioglitazone. Systems pharmacology models integrating physiology and experimental data can evaluate DILI mechanisms and may be useful to predict hepatotoxic potential of drug candidates.
Closing the proximity gap in a metallic Josephson junction between three superconductors
Creators: name: Padurariu, C.
name: Jonckheere, T.
name: Rech, J.
name: Mélin, R.
name: Feinberg, D.
name: Martin, T.
name: Nazarov, Yu. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We describe the proximity effect in a short disordered metallic junction between three superconducting leads. Andreev bound states in the multi-terminal junction may cross the Fermi level. We reveal that for a quasi-continuous metallic density of states, crossings at the Fermi level manifest as closing of the proximity-induced gap. We calculate the local density of states for a wide range of transport parameters using quantum circuit theory. The gap closes inside an area of the space spanned by the superconducting phase differences. We derive an approximate analytic expression for the boundary of the area and compare it to the full numerical solution. The size of the area increases with the transparency of the junction and is sensitive to asymmetry. The finite density of states at zero energy is unaffected by electron-hole decoherence present in the junction, although decoherence is important at higher energies. Our predictions can be tested using tunneling transport spectroscopy. To encourage experiments, we calculate the current-voltage characteristic in a typical measurement setup. We show how the structure of the local density of states can be mapped out from the measurement.
description: 8 pages, 7 figures
Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis
Creators: name: Stewart, P. W.
name: Johnston, C. K.
name: Ferslew, B. C.
name: Jia, W.
name: Brouwer, K. L.R.
name: Tsakalozou, E.
name: Barritt, A. S.
name: Paine, M. F.
name: Bridges, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The functional impact of altered drug transport protein expression on the systemic pharmacokinetics of morphine, hepatically-derived morphine glucuronide (morphine-3- and morphine-6-glucuronide), and fasting bile acids was evaluated in patients with biopsy-confirmed non-alcoholic steatohepatitis (NASH) compared to healthy subjects. The maximum concentration (Cmax) and area under the concentration-time curve (AUC0-last) of morphine glucuronide in serum were increased in NASH patients (343 vs. 225nM and 58.8 vs. 37.2μM*min, respectively; P≤0.005); morphine pharmacokinetics did not differ between groups. Linear regression analyses detected an association of NASH severity with increased morphine glucuronide Cmax and AUC0-last (P<0.001). Fasting serum glycocholate, taurocholate and total bile acid concentrations were associated with NASH severity (P<0.006). Increased hepatic basolateral efflux of morphine glucuronide and bile acids is consistent with altered hepatic transport protein expression in patients with NASH and may partially explain differences in efficacy and/or toxicity of some highly transported anionic drugs/metabolites in this patient population.
Supplementary Material from A random-matrix theory of the number sense
Creators: name: T. Hannagan
name: A. Nieder
name: P. Viswanathan
name: S. Dehaene
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Methods and analyses. Supplementary Notes 1 to 11; Supplementary Figures 1 to 5; Supplementary Tables 1 to 3; Supplementary References
title: Post-therapeutic aspect of squamous cell carcinoma of the oropharynx and oral cavity on imaging
Creators: name: OUKASSEM, SIHAM
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Oncology
subject: Radiation physics
subject: CT
subject: MR
subject: PET-CT
subject: Complications
subject: Radiation therapy / Oncology
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The objective of this study is to illustrate the radiological aspect of the postoperative complications as well as the complications of radiotherapy according to the operative status of the patient (excisional and reconstruction surgery) and the...
Androgen receptor targeting drugs in castration-resistant prostate cancer and mechanisms of resistance
Creators: name: Whang, Y. E.
name: Milowsky, M. I.
name: Crona, D. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Reactivated androgen receptor (AR) signaling drives castration-resistant prostate cancer (CRPC). Novel AR targeting drugs abiraterone and enzalutamide have improved survival of CRPC patients. However, resistance to these agents develops and patients ultimately succumb to CRPC. Potential mechanisms of resistance include the following: 1) Expression of AR splice variants such as the AR-V7 isoform which lacks the ligand-binding domain, 2) AR missense mutations in the ligand-binding domain, such as F876L and T877A, and 3) Mutation or overexpression of androgen biosynthetic enzymes or glucocorticoid receptor. Several novel agents may overcome resistance mechanisms. Galeterone acts through multiple mechanisms that include degradation of AR protein and is being evaluated in CRPC patients positive for AR-V7. EPI-001 and related compounds inhibit AR splice variants by targeting the N-terminal transactivation domain of AR. Promising therapies and novel biomarkers, such as AR-V7, may lead to improved outcomes for CRPC patients.
(400912) Betrand Aubrey Palmer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dalla festa di Iside a quella di Sant’Agata Una storia di culti femminili
Creators: name: Nonveiller, Elena
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Isis cults
Saint Agatha
Female cults

description: In the paper the author aims to examine some aspects of the history of the official cult of Saint Agatha, in Sicily and Constantinople, starting with the Greco-Roman cults of Isis, and then focusing in particular on the unofficial or the initiatory women’s festival, celebrated in Constantinople, attested by only one literary source from the 11th century AD. This source, consisting of a short philosophical treatise, ascribed to Michael Psellos, informs us about some interesting aspects of the religious and social life of women in Constantinople in the mid-Byzantine era.
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group
Creators: name: Brouwer, K. L.R.
name: Giacoia, G. P.
name: Wildt, Sn De
name: Lukacova, V.
name: Meibohm, B.
name: M Rieder, M.
name: Aleksunes, L. M.
name: Knipp, G.
name: Nigam, Sk
name: Brandys, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
title: Vulvar cancer imaging: what the radiologist needs to know
Creators: name: Sivagurunathan, Gayathri
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Oncology
subject: MR
subject: PET-CT
subject: Staging
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To learn the MRI anatomy of the vulva. FIGO staging and corresponding MRI appearances. Follow-up and recurrent disease imaging....
Body composition assessment in overweight women: validation of air displacement plethysmography
Creators: name: Smith-Ryan, Abbie E.
name: Wingfield, Hailee L.
name: Graff, Rachel M.
name: Woessner, Mary N.
name: Fultz, Sarah N.
name: Melvin, Malia N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The purpose of this study was to evaluate the validity and reliability of air displacement plethysmography (ADP) compared to a dual energy x-ray absorptiometry (DXA) criterion for body composition measurement in overweight and obese women (BMI ≥ 25.0 kg m2).
Dynamics of locally coupled agents with next nearest neighbor interaction
Creators: name: Herbrych, J.
name: Chazirakis, A. G.
name: Christakis, N.
name: Veerman, J. J. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We consider large but finite systems of identical agents on the line with up to next nearest neighbor asymmetric coupling. Each agent is modelled by a linear second order differential equation, linearly coupled to up to four of its neighbors. The only restriction we impose is that the equations are decentralized. In this generality we give the conditions for stability of these systems. For stable systems, we find the response to a change of course by the leader. This response is at least linear in the size of the flock. Depending on the system parameters, two types of solutions have been found: damped oscillations and reflectionless waves. The latter is a novel result and a feature of systems with at least next nearest neighbor interactions. Analytical predictions are tested in numerical simulations.
Efficient extraction of proteins from formalin-fixed paraffin-embedded tissues requires higher concentration of tris(hydroxymethyl)aminomethane
Creators: name: Matsumoto, Hiroyuki
name: Kodera, Yoshio
name: Matsumoto, Masaomi
name: Kawashima, Yusuke
name: Singh, Anil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundNumerous formaldehyde-fixed and paraffin-embedded clinical tissues have been created in the past decades and stored in pathological depositories at hospitals as well as in clinical laboratories worldwide. In addition to the archived tissues, formaldehyde-fixation is also mandatory for preparing proteomics samples from diseased patients or animal models in order to inactivate contagious agents. Protein extraction from formaldehyde-fixed tissues is hampered by the Schiff base formation between the amino groups of proteins and formaldehyde. Although achievement of the highest extraction efficiency of proteins from the formaldehyde-fixed tissues is essential for obtaining maximum proteomics information, no attention has been paid to the concentration dependence of tris(hydroxymethyl)aminomethane on the extraction efficacy. We suspected that the concentration of tris(hydroxymethyl)aminomethane affects the protein extraction efficiency because of its property as a primary amine that reverses the Schiff base formation between the primary amines of proteins and formaldehyde. Thus we pursued optimization of the component and protocol of protein extraction buffer to achieve better extraction efficiency of proteins from formaldehyde-fixed and paraffin-embedded tissues.ResultsIn order to simulate protein extraction from diseased tissues we made formaldehyde-fixed and paraffin-embedded samples from mouse liver slices and investigated the protein extraction efficiency and speed by changing the concentration of the protein extraction buffer component tris(hydroxymethyl)aminomethane under various extraction conditions. We find, as expected, that tris(hydroxymethyl)aminomethane significantly affects the performance of protein extraction from the formaldehyde-fixed and paraffin-embedded samples both in the extraction yield and in the extraction speed.ConclusionsWe recommend the concentration of tris(hydroxymethyl)aminomethane in protein extraction buffer to be higher than 300mM when extraction is conducted for 90min at 90°C to achieve the most efficient protein extraction in a shorter time. The information will be essential for performing the most efficient protein extraction from formaldehyde-fixed and paraffin-embedded tissue samples for proteomics analysis.
title: A dedicated technical acquisition protocol for magnetic resonance imaging cholangiography in patients with sclerosing cholangitis
Creators: name: Amelio, Matteo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: MR
subject: MR-Cholangiography
subject: Diagnostic procedure
subject: Technical aspects
subject: Cancer
subject: Dilatation
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The purpose of this study is to present the technical protocol for functional magnetic resonance cholangiography in patients with sclerosing cholangitis adopted in our Institute: The IRCCS Policlinico Sant'Orsola-Malpighi,...
title: Imaging the unborn: Fetal MRI in evaluation of the fetal abdomen- a case based review
Creators: name: Prakash, Aparna
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Foetal imaging
subject: Gastrointestinal tract
subject: MR
subject: Diagnostic procedure
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Fetal MRI is well established as a complementary modality to ultrasound in fetal imaging and can confirm findings of sonography providing additional useful information and structural detail. Its safety is well established,(1) and it is an...
Improving risk assessment of violence among military Veterans: An evidence-based approach for clinical decision-making
Creators: name: Brooks, Stephanie
name: Johnson, Sally C.
name: Kinneer, Patricia
name: Beckham, Jean C.
name: Elbogen, Eric B.
name: Fuller, Sara
name: Calhoun, Patrick S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Despite increased media attention on violent acts against others committed by military Veterans, few models have been developed to systematically guide violence risk assessment among Veterans. Ideally, a model would identify which Veterans are most at risk for violence and increased attention could then be turned to determining what could be done to prevent violent behavior. This article suggests how empirical approaches to risk assessment used successfully in civilian populations can be applied to Veterans. A review was conducted of the scientific literature on Veteran populations regarding factors related to interpersonal violence generally and to domestic violence specifically. A list was then generated of empirically-supported risk factors for clinicians to consider in practice. To conceptualize how these known risk factors relate to a Veteran’s violence potential, risk assessment scholarship was utilized to develop an evidence-based method to guide mental health professionals. The goals of this approach are to integrate science into practice, overcome logistical barriers, and permit more effective assessment, monitoring, and management of violence risk for clinicians working with Veterans, both in Veteran Administration settings and in the broader community. It is likely that the use of a systematic, empirical framework could lead to improved clinical decision-making in the area of risk assessment, and help reduce violence among Veterans.
ДИАГНОТИКА ОСТРОГО ИНФАРКТА МИОКАРДА С ПЕРЕД ХИРУРГИЧЕСКИМ ВМЕШАТЕЛЬСТВОМ: ВЫСОКО ЧУВСТВИТЕЛЬНЫЙ ТРОПОНИНТ ИЛИ АМИНОТЕРМИНАЛЬНЫЙ ФРАГМЕНТ ПРО-МОЗГОВОГО НАТРИЙУРЕТИЧЕСКОГО ПЕПТИДА ТИПА В?
Creators: name: Сафаров, Диёр
name: Омонкулова, Жасмина
name: Рахманов, Маьмуржон
Publisher: name: Zenodo
Year: 2024

description: Currently, there are data in the literature about the importance of the aminoterminal fragment of pro-brain natriuretic peptide type B in the diagnosis of patients with acute myocardial infarction.
title: A practical review of ultrasound images in intestinal neoplasms
Creators: name: Martinez Perez, Maria Jesus
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Colon
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Comparative studies
subject: Education
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: -Describe and illustrate different ultrasound (US) manifestations of gastrointestinal (GI) neoplasms, highlighting presentation patterns, more frequent locations and features -Evaluate different presentation aspects and possible complications. -Show...
Upward spirals of positive emotions counter downward spirals of negativity: Insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology
Creators: name: Johnson, David P.
name: Garland, Eric L.
name: Meyer, Piper S.
name: Kring, Ann M.
name: Fredrickson, Barbara
name: Penn, David L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: This review integrates Fredrickson’s broaden-and-build theory of positive emotions with advances in affective neuroscience regarding plasticity in the neural circuitry of emotions to inform the treatment of emotion deficits within psychopathology. We first present a body of research showing that positive emotions broaden cognition and behavioral repertoires, and in so doing, build durable biopsychosocial resources that support coping and flourishing mental health. Next, by explicating the processes through which momentary experiences of emotions may accrue into self-perpetuating emotional systems, the current review proposes an underlying architecture of state-trait interactions that engenders lasting affective dispositions. This theoretical framework is then used to elucidate the cognitive-emotional mechanisms underpinning three disorders of affect regulation, depression, anxiety, and schizophrenia. In turn, two mind training interventions, mindfulness and loving-kindness meditation, are highlighted as means of generating positive emotions that may counter the negative affective processes implicated in these disorders. We conclude with the proposition that positive emotions may exert a countervailing force on the dysphoric, fearful, or anhedonic states characteristic of persons with psychopathology typified by emotional dysfunctions.
A Visualization of Null Geodesics for the Bonnor Massive Dipole
Creators: name: Oliva-Mercado, Guillermo Andree
name: Bonatti-González, Javier
name: Cordero-García, Iván
name: Frutos-Alfaro, Francisco
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this work we simulate null geodesics for the Bonnor massive dipole metric by implementing a symbolic-numerical algorithm in Sage and Python. This program is also capable of visualizing in 3D, in principle, the geodesics for any given metric. Geodesics are launched from a common point, collectively forming a cone of light beams, simulating a solid-angle section of a point source in front of a massive object with a magnetic field. Parallel light beams also were considered, and their bending due to the curvature of the space-time was simulated.
description: 9 pages, 5 figures, Presented at XIX Simposio Internacional de M\'etodos Matem\'aticos Aplicados a las Ciencias (19th International Symposium of Mathematical Methods Applied to Sciences, XIX-SIMMAC)
title: Tuberculosis or Inflammatory Bowel Disease – A Diagnostic conundrum in an Indian scenario
Creators: name: KUMAR, T SEETAM
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Gastrointestinal tract
subject: CT
subject: CT-Enterography
subject: Contrast agent-intravenous
subject: Contrast agent-oral
subject: Infection
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: -To classify subtle signs of abdominal tuberculosis compared with Crohn's disease (CD) -Describing radiological signs of Inflammatory Bowel Disease (IBD) -In an Indian context, it's always a conundrum but to differentiate each other by more chances...
A review of parenting and adolescent sexual behavior: The moderating role of gender
Creators: name: Sterrett, Emma
name: Kincaid, Carlye
name: Jones, Deborah J.
name: McKee, Laura
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In spite of the established link between parenting and adolescent sexual risk behavior, less is known about the role of adolescent gender as a potential moderator of this association. This literature review integrates findings from 24 studies to examine gender as a moderator of the link between parenting and youth sexual risk behavior. Despite the wide variability in methodology across the reviewed studies, findings suggest that monitoring may be more protective against sexual risk behavior for boys than girls, whereas parental warmth and emotional connection may be an especially salient factor for girls. The results of this review support further research on gender as an important factor in better understanding the role of parenting in the development of adolescent sexual behavior. Furthermore, the findings highlight the potential role of gender-specific, tailored family-focused prevention programs targeting sexual behavior.
Gauge Freedom in Path Integrals in Abelian Gauge Theory
Creators: name: Saito, Teijiro
name: Endo, Ryusuke
name: Miura, Hikaru
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We extend gauge symmetry of Abelian gauge field to incorporate quantum gauge degrees of freedom. We twice apply the Harada--Tsutsui gauge recovery procedure to gauge-fixed theories. First, starting from the Faddeev--Popov path integral in the Landau gauge, we recover the gauge symmetry by introducing an additional field as an extended gauge degree of freedom. Fixing the extended gauge symmetry by the usual Faddeev--Popov procedure, we obtain the theory of Type I gaugeon formalism. Next, applying the same procedure to the resulting gauge-fixed theory, we obtain a theory equivalent to the extended Type I gaugeon formalism.
description: 16 pages
title: Which is the best time point to assess complete response after concurrent chemoradiotherapy in locally advanced cervical cancer? Preliminary results.
Creators: name: D'Erme, Luca
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Oncology
subject: Pelvis
subject: MR
subject: Radiation therapy / Oncology
subject: Multidisciplinary cancer care

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Cervical cancer (CC) is the fourth most common cancer in women, representing the first gynaecological malignancy worldwide [1]. Concurrent chemoradiation (CTRT) is the established standard of care for locally advanced cervical cancer (LACC),...
(400914) Francis John William Palmer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary materials from The functional syndrome: linking individual trait variability to ecosystem functioning.
Creators: name: Raffard, Allan
name: Lecerf, Antoine
name: Cote, Julien
name: Buoro, Mathieu
name: Lassus, Remy
name: Cucherousset, Julien
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Phenotypic variability is increasingly assessed through functional response and effect traits, which provide a mechanistic framework for investigating how an organism responds to varying ecological factors and how these responses affect ecosystem functioning. Covariation between response and effect traits has been poorly examined at the intraspecific level, thus hampering progress in understanding how phenotypic variability alters the role of organisms in ecosystems. Using a multi-trait approach and a nine-month longitudinal monitoring of individual red-swamp crayfish (Procambarus clarkii), we demonstrated that most of the measured response and effect traits were partially stable during the ontogeny of individuals. Suites of response and effect traits were associated with a response syndrome and an effect syndrome, respectively, which were correlated to form a functional syndrome. Using a bioenergetic model, we predicted that differences in the response syndrome composition of hypothetical populations had important ecological effects on a key ecosystem process (i.e. whole-lake litter decomposition) to a level similar to those induced by doubling population size. Demonstrating the existence of a functional syndrome is likely to improve our understanding of the ecological impacts of phenotypic variation among individuals in wild populations across levels of biological organization, and the linkage between ecosystem and evolutionary ecology.
Creativity and bipolar disorder: Touched by fire or burning with questions?
Creators: name: Youngstrom, Eric A.
name: Schooler, Jonathan
name: Johnson, Sheri L.
name: Fredrickson, Barbara
name: Bass, Julie Malbrancq
name: Salloum, Ihsan
name: Deckersbach, Thilo
name: Murray, Greg
name: Hinshaw, Stephen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Substantial literature has linked bipolar disorder with creative accomplishment. Much of the thinking in this area has been inspired by biographical accounts of poets, musicians, and other highly accomplished groups, which frequently document signs of bipolar disorder in these samples. A smaller literature has examined quantitative measures of creativity among people with bipolar disorder or at risk for the disorder. In this paper, we provide a critical review of such evidence. We then consider putative mechanisms related to the link of bipolar disorder with creativity, by drawing on literature outside of bipolar disorder on personality, motivational, and affective predictors of creativity. Because so little research has directly evaluated whether these factors could help explain the elevations of creativity in bipolar disorder, we conclude with an agenda for future research on the theoretically and clinically compelling topic of creativity in bipolar disorder.
Behavioral parenting interventions for child disruptive behaviors and anxiety: What's different and what's the same
Creators: name: Forehand, Rex
name: Jones, Deborah J.
name: Parent, Justin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: This paper reviews the role of parents in behavioral interventions with children’s disruptive and anxiety problems. The evolution of interventions for these two types of problems differs, as has the role of parents in these interventions. In contrast to the central role of parents in the conceptualization and treatment of disruptive behaviors, parents have played a more varied and less prominent role in the conceptualization and treatment of children’s anxiety. Furthermore, the literature involving parents in the treatment of children’s anxiety indicates these interventions are more efficacious than control groups but not more efficacious than intervening with the child alone. Some limited evidence emerges for parenting as a mediator in the treatment of disruptive behaviors, but not of anxiety, where the role of parenting has rarely been measured. Implications for conceptualizing the role of parents in intervention programs for youth are discussed and directions for future research are delineated (e.g., collecting long term follow-up data, examine moderators of treatment response, develop programs for comorbid diagnoses).
Supplementary materials from The functional syndrome: linking individual trait variability to ecosystem functioning
Creators: name: Raffard, Allan
name: Lecerf, Antoine
name: Cote, Julien
name: Buoro, Mathieu
name: Lassus, Remy
name: Cucherousset, Julien
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Phenotypic variability is increasingly assessed through functional response and effect traits, which provide a mechanistic framework for investigating how an organism responds to varying ecological factors and how these responses affect ecosystem functioning. Covariation between response and effect traits has been poorly examined at the intraspecific level, thus hampering progress in understanding how phenotypic variability alters the role of organisms in ecosystems. Using a multi-trait approach and a nine-month longitudinal monitoring of individual red-swamp crayfish (Procambarus clarkii), we demonstrated that most of the measured response and effect traits were partially stable during the ontogeny of individuals. Suites of response and effect traits were associated with a response syndrome and an effect syndrome, respectively, which were correlated to form a functional syndrome. Using a bioenergetic model, we predicted that differences in the response syndrome composition of hypothetical populations had important ecological effects on a key ecosystem process (i.e. whole-lake litter decomposition) to a level similar to those induced by doubling population size. Demonstrating the existence of a functional syndrome is likely to improve our understanding of the ecological impacts of phenotypic variation among individuals in wild populations across levels of biological organization, and the linkage between ecosystem and evolutionary ecology.