cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells
Creators: name: Nanumi Han
name: Delnur Anwar
name: Hama, Naoki
name: Kobayashi, Takuto
name: Suzuki, Hidefumi
name: Takahashi, Hidehisa
name: Wada, Haruka
name: Otsuka, Ryo
name: Baghdadi, Muhammad
name: Seino, Ken-Ichiro
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 2: Supplementary Figure 2. Analysis of histone acetylation in Il34OE HM-1 derived by EF1α promoter. Percent of input values of H3K27ac in Il34OE HM-1 cells analyzed by ChIP-qPCR. Genomic DNA from JQ1 or DMSO treated HM-1 cells was immunoprecipitated with anti-H3K27ac antibody or control IgG, and amplified by qPCR with EF1α promoter region’s primer pairs. Data represents as mean ± SEM (n = 3). ND; not detected. NS; not significant, Student’s t-test.
The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β during Chlamydia trachomatis Infection
Creators: name: Marinov, Anthony
name: Nagarajan, Uma M.
name: Yeruva, Laxmi
name: Zhang, Yugen
name: Lupashin, Vladimir
name: Wyrick, Priscilla B.
name: Prantner, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: IFNβ has been implicated as an effector of oviduct pathology resulting from genital chlamydial infection in the mouse model. In this study, we investigated the role of cytosolic DNA and engagement of DNA sensors in IFNβ expression during chlamydial infection. We determined that TREX-1, a host 3’to 5’ exonuclease, reduced IFNβ expression significantly during chlamydial infection using siRNA and gene knock out fibroblasts, implicating cytosolic DNA as a ligand for this response. The DNA sensor cGAS has been shown to bind cytosolic DNA to generate cGAMP, which binds to the signaling adaptor STING to induce IFNβ expression. We determined that cGAS is required for IFNβ expression during chlamydial infection in multiple cell types. Interestingly, although infected cells deficient for STING or cGAS alone failed to induce IFNβ, co-culture of cells depleted for either STING or cGAS rescued IFNβ expression. These data demonstrate that cGAMP produced in infected cGAS+STING− cells can migrate into adjacent cells via gap junctions to function in trans in cGAS−STING+ cells. Further, we observed cGAS localized in punctate regions on the cytosolic side of the chlamydial inclusion membrane in association with STING, indicating that chlamydial DNA is likely recognized outside the inclusion as infection progresses. These novel findings provide evidence that cGAS-mediated-DNA sensing directs IFNβ expression during C.trachomatis infection and suggests that effectors from infected cells can directly upregulate IFNβ expression in adjacent uninfected cells during in vivo infection, contributing to pathogenesis.
(1802) William Ballantyne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ÉTUDE COMPARATIVE DE L'ACCUMULATION BIOLOGIQUE DE QUELQUES OLIGO-ÉLÉMENTS MÉTALLIQUES DANS L'ESTUAIRE INTERNE DE LA LOIRE ET LES ZONES NÉRITIQUES VOISINES (BAIE DE BOURGNEUF)
Creators: name: AMIARD-TRIQUET, C.
name: AMIARD, J.C.
name: ROBERT, J.M.
name: MÉTAYER, C.
name: MARCHAND, J.
name: MARTIN, J.L.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1983

Abstract
(1803) John Cowan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1804) Hugh Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of A qualitative study of how clinicians reach agreement in perioperative pathway development: the Consensus Model for Standardising Healthcare
Creators: name: Pagano, Lisa
name: Long, Janet C.
name: Francis-Auton, Emilie
name: Hirschhorn, Andrew
name: Arnolda, Gaston
name: Braithwaite, Jeffrey
name: Sarkies, Mitchell N.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Supplementary Material 1. Standards for Reporting Qualitative Research (SRQR) checklist, (.pdf). Populated checklist of ‘Standards for Reporting Qualitative Research’ reporting guidelines indicating how the manuscript adheres to the relevant guidelines.
Variabilité du microphytoplancton et des Tintinnida (Protozoaires Ciliés) d'un secteur eutrophe du golfe d'Annaba (Méditerranée sud-occidentale)
Creators: name: OUNISSI, Makhlouf
name: FREHI, Hocine
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: Variability of microphytoplankton and Tintinnida (Ciliated Protozoa) in an eutrophic sector of  the Annaba Gulf (S.W.
 Mediterranean). The western sector of the Annaba Gulf is a bay opened to the outside neritic water and to the continental discharge
 proceeding principally from the Seybouse river. The plankton was sampled monthly by horizontal hauls in four stations in 1992. The
 results show the existence of two zones fundamentally different: the zone of interface, receiving the continental runoff, and the zone
 exposed directly to the intrusion of the outside waters. The first zone is highly fertile and distinguished by the low transparency and low
 salinity of enclosed waters. It shelters dense but weakly diversified populations. Diatom populations are abundant and comprise principally
 Coscinodiscus radiatus, Chaetoceros curvisetus, Chaetoceros spp. and Rhizosolenia spp.. The Dinophycea Protoperidinium depressum,
 Dinophysis caudata, Ceratium spp. can, in hot season, develop into strong abundance. On the other hand, Tintinnida exhibit demographic
 explosions, particularly in summer and comprise essentially 4-5 opportunists species such as Favella serrata, Tintinnopsis campanula,
 Porecus apiculatus, Codonellopsis morchella. The second zone is characterized by its more transparent and renewed water with a low
 fertility. Dinoflagellates dominate in this area and diatom and tintinnid populations decrease in density and their hierarchy abundance is
 modified. The proliferation of Pseudo-nitzschia multiseries in April spreads however to the whole sector. It appears finally, that the fraction
 of the studied planktonic Protista seems to be controlled principally by the physical factors (intrusion of external neritic water and
 continental runoff).
Non standard neutrino interactions
Creators: name: Miranda, O. G.
name: Nunokawa, H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Neutrino oscillations have become well-known phenomenon; the measurements of neutrino mixing angles and mass squared differences are continuously improving. Future oscillation experiments will eventually determine the remaining unknown neutrino parameters, namely, the mass ordering, normal or inverted, and the CP-violating phase. On the other hand, the absolute mass scale of neutrinos could be probed by cosmological observations, single beta decay as well as by neutrinoless double beta decay experiments. Furthermore, the last one may shed light on the nature of neutrinos, Dirac or Majorana, by measuring the effective Majorana mass of neutrinos. However, the neutrino mass generation mechanism remains unknown. A well-motivated phenomenological approach to search for new physics, in the neutrino sector, is that of non-standard interactions. In this short review, the current constraints in this picture, as well as the perspectives from future experiments, are discussed.
description: 22 pages, 6 figures
Additional file 2 of A qualitative study of how clinicians reach agreement in perioperative pathway development: the Consensus Model for Standardising Healthcare
Creators: name: Pagano, Lisa
name: Long, Janet C.
name: Francis-Auton, Emilie
name: Hirschhorn, Andrew
name: Arnolda, Gaston
name: Braithwaite, Jeffrey
name: Sarkies, Mitchell N.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Supplementary Material 2. Topic guide for semi structured interviews utilised for surgeons, (.pdf). Provides the topic guide initially piloted by the research team and used to guide the interviewer in the semi-structured interviews for patients.
Spitzer Imaging of Strongly-Lensed Herschel-Selected Dusty Star Forming Galaxies
Creators: name: Ma, Brian
name: Cooray, Asantha
name: Calanog, J. A.
name: Nayyeri, H.
name: Timmons, N.
name: Casey, C.
name: Baes, M.
name: Chapman, S.
name: Dannerbauer, H.
name: Da Cunha, E. L.
name: De Zotti, G.
name: Dunne, L.
name: Farrah, D.
name: Fu, Hai
name: Gonzalez-Nuevo, J.
name: Magdis, G.
name: Michalowski, M. J.
name: Oteo, I.
name: Riechers, D. A.
name: Scott, D.
name: Smith, M. W. L.
name: Wang, L.
name: Wardlow, J.
name: Vaccari, M.
name: Viaene, S.
name: Vieira, J. D.
name: Vaccari, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the rest-frame optical spectral energy distribution and stellar masses of six Herschel- selected gravitationally lensed dusty, star-forming galaxies (DSFGs) at 1 < z < 3. These galaxies were first identified with Herschel/SPIRE imaging data from the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) and the Herschel Multi-tiered Extragalactic Survey (HerMES). The targets were observed with Spitzer/IRAC at 3.6 and 4.5um. Due to the spatial resolution of the IRAC observations at the level of 2 arcseconds, the lensing features of a background DSFG in the near-infrared are blended with the flux from the foreground lensing galaxy in the IRAC imaging data. We make use of higher resolution Hubble/WFC3 or Keck/NIRC2 Adaptive Optics imaging data to fit light profiles of the foreground lensing galaxy (or galaxies) as a way to model the foreground components, in order to successfully disentangle the foreground lens and background source flux densities in the IRAC images. The flux density measurements at 3.6 and 4.5um, once combined with Hubble/WFC3 and Keck/NIRC2 data, provide important constraints on the rest-frame optical spectral energy distribution of the Herschel-selected lensed DSFGs. We model the combined UV- to millimeter-wavelength SEDs to establish the stellar mass, dust mass, star-formation rate, visual extinction, and other parameters for each of these Herschel-selected DSFGs. These systems have inferred stellar masses in the range 8 x 10^10 to 4 x 10^11 Msun and star-formation rates of around 100 Msun yr-1. This puts these lensed sub-millimeter systems well above the SFR-M* relation observed for normal star-forming galaxies at similar redshifts. The high values of SFR inferred for these systems are consistent with a major merger-driven scenario for star formation.
description: 13 pages, 6 figures, submit to ApJ
Horava Gravity in the Effective Field Theory formalism: from cosmology to observational constraints
Creators: name: Frusciante, Noemi
name: Raveri, Marco
name: Vernieri, Daniele
name: Hu, Bin
name: Silvestri, Alessandra
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider Horava gravity within the framework of the effective field theory (EFT) of dark energy and modified gravity. We work out a complete mapping of the theory into the EFT language for an action including all the operators which are relevant for linear perturbations with up to sixth order spatial derivatives. We then employ an updated version of the EFTCAMB/EFTCosmoMC package to study the cosmology of the low-energy limit of Horava gravity and place constraints on its parameters using several cosmological data sets. In particular we use cosmic microwave background (CMB) temperature-temperature and lensing power spectra by Planck 2013, WMAP low-l polarization spectra, WiggleZ galaxy power spectrum, local Hubble measurements, Supernovae data from SNLS, SDSS and HST and the baryon acoustic oscillations measurements from BOSS, SDSS and 6dFGS. We get improved upper bounds, with respect to those from Big Bang Nucleosynthesis, on the deviation of the cosmological gravitational constant from the local Newtonian one. At the level of the background phenomenology, we find a relevant rescaling of the Hubble rate at all epoch, which has a strong impact on the cosmological observables; at the level of perturbations, we discuss in details all the relevant effects on the observables and find that in general the quasi-static approximation is not safe to describe the evolution of perturbations. Overall we find that the effects of the modifications induced by the low-energy Horava gravity action are quite dramatic and current data place tight bounds on the theory parameters.
description: v1: 27 pages, 7 figures. v2: 28 pages, 7 figures. Changes in Figs. 2,3,4,6,7 and Tabs. 1,2. Matches published version in Phys. Dark Univ
Nouvelles signalisations d'espèces benthiques sur les côtes françaises de la Manche orientale et de la Mer du Nord
Creators: name: DAVOULT, Dominique
name: DEWARUMEZ, Jean-Marie
name: LUCZAK, Christophe
name: MIGNÉ, Aline
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: New reports of benthic species from the french coasts of the eastern English Channel and the North Sea. Twenty
 six benthic species from several phyla have been found for the first time in the French part of the eastern English Channel
 and of the North sea : one Nematoda (Synonchus brevisetosus), one Nemertean (Tetrastemma helvolum), twelve polychaeta
 Annelida (Spio decoratus, Capitella giardi, Mediomastus fragilis, Phyllodoce longipes, Hesionura elongata, Glycera
 celtica, Glycera oxycephala, Nephtys assimilis, Myriochele oculata, Chone filicaudata, Fabricia sabella and Protodriloides
 chaetifer), one lamellibranchiata Mollusca (Ensis directus), five Bryozoans (Eurystrotos compacta, Scruparia ambigua,
 Amphiblestrum flemingii, Hippopodinella lata and Plesiothoa gigerium), one Phoronida (Phoronis muelleri), one Entoprocta
 (Pedicellina hispida) and four malacostracean Crustacea (Harpinia antennaria, Idotea metallica, Tanaopsis graciloides and
 Gastrosaccus sanctus). Their biotope and geographical distribution are discussed and compared with data from the literature.
Additional file 3 of A qualitative study of how clinicians reach agreement in perioperative pathway development: the Consensus Model for Standardising Healthcare
Creators: name: Pagano, Lisa
name: Long, Janet C.
name: Francis-Auton, Emilie
name: Hirschhorn, Andrew
name: Arnolda, Gaston
name: Braithwaite, Jeffrey
name: Sarkies, Mitchell N.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Supplementary Material 3. Topic guide for semi structured interviews utilised for allied health and nursing staff, (.pdf). Provides the topic guide initially piloted by the research team and used to guide the interviewer in the semi-structured interviews for clinicians.
Morphological and molecular characterization of Perinereis gualpensis (Polychaeta: Nereididae) and its phylogenetic relationships with other species of the genus off the Chilean coast, Southeast Pacific
Creators: name: SAMPÉRTEGUI, Sandra
name: ROZBACZYLO, Nicolás
name: CANALES-AGUIRRE, Cristian B.
name: CARRASCO, Franklin
name: HERNÁNDEZ, Cristián E.
name: RODRÍGUEZ-SERRANO, Enrique
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The genus Perinereis, family Nereididae, consists of approximately 66 worldwide distributed species with marine, estuarine, and freshwater representatives. The objective of this study is to use morphological and molecular traits to evaluate the taxonomic differentiation of the estuarine polychaete P. gualpensis. Also we reconstruct the phylogenetic relationships between P. gualpensis and congeneric species recorded in Chilean coast: P. falklandica, P. longidonta and, especially with the morphologically most similar species, P. vallata. Phylogenetic analyses based on molecular and morphological characters allow us to validate P. gualpensis and P. vallata as two independent and clearly defined species. Consequently, the taxonomic confusion about the possible sibling species P. gualpensis and P. vallata is completely resolved. However, morphological and genetic data are partially incongruent about the phylogenetic relationships of these four Perinereis species. We concluded that different evolutionary process that affect the morphological and genetics data produce different answers. Also we propose the use of new molecular evidence arising from molecular markers with different nucleotide substitution rate to that used here.
Experimental Realization of an Incompressible Newtonian Fluid in Two Dimensions
Creators: name: Qi, Zhiyuan
name: Park, Cheol Soo
name: Glaser, Matthew A.
name: Maclennan, Joseph E.
name: Clark, Noel A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The Brownian diffusion of micron-scale inclusions in freely suspended smectic A liquid crystal films a few nanometers thick and several millimeters in diameter depends strongly on the air surrounding the film. Near atmospheric pressure, the three-dimensionally coupled film/gas system is well described by Hughes/Pailthorpe/White hydrodynamic theory but at lower pressure (p < 70 torr), the diffusion coefficient increases substantially, tending in high vacuum toward the two-dimensional limit where it is determined by film size. In the absence of air, the films are found to be a nearly ideal physical realization of a two-dimensional, incompressible Newtonian fluid.
description: 5 pages, 3 figures
(1801) Walter Washington Buchanan Rodgerof Bagatelle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Diet of juveniles Mediterranean horse mackerel, Trachurus mediterraneus and horse mackerel, Trachurus trachurus (Carangidae), from the eastern central Adriatic
Creators: name: ŠANTIĆ, Mate
name: RAĐA, Biljana
name: PALLAORO, Armin
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The diet of juveniles Trachurus mediterraneus and Trachurus trachurus, in the eastern central Adriatic was investigated with respect to season and sampling localities. Specimens were collected from three localities between January 2007 and December 2008. The diet of juveniles Mediterranean horse mackerel and horse mackerel consisted mainly of Copepoda, Euphausiacea, Cladocera, Mysidacea, Amphipods and teleost eggs. For both species, planktonic copepod crustaceans were the most important ingested prey in all season and sampling localities. According to cluster, diet analysis of T. mediterraneus and T. trachurus species was similar in all sampling localities and during spring, summer and autumn. Feeding intensity for these species is very high as indicated by low vacuity index and high stomach fullness index. High values of diet overlap coefficients indicate that these two species exploit similar food resources in early stage of development.
POLYCYCLA (URCEOLARIA) SYNAPTAE CUÉNOT
Creators: name: FAURÉ-FREMIET, E.
name: CZAPIK, A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: One of the morphological characteristics of Polycycla synaptae is the presence of numerous motile cilia covering the central surface of the adhesive disc. This fact shows that, among the Peritrichida, the restrictive specialization of the thigmotactic area (the scopula) can be reversed during the course of evolution and specific diversification.
The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction in Endothelial Cells To Stimulate Transendothelial Migration
Creators: name: Guilluy, Christophe
name: Monaghan-Benson, Elizabeth
name: Osborne, Lukas D.
name: Superfine, Richard
name: O'Brien, E. Timothy
name: Lessey-Morillon, Elizabeth C.
name: Burridge, Keith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: RhoA-mediated cytoskeletal rearrangements in endothelial cells (ECs) play an active role in leukocyte transendothelial cell migration (TEM), a normal physiological process in which leukocytes cross the endothelium to enter the underlying tissue. Although much has been learned about RhoA signaling pathways downstream from ICAM-1 in ECs, little is known about the consequences of the tractional forces that leukocytes generate on ECs as they migrate over the surface before TEM. We have found that after applying mechanical forces to ICAM-1 clusters, there is an increase in cellular stiffening and enhanced RhoA signaling compared with ICAM-1 clustering alone. We have identified that leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF 12 (ARHGEF12) acts downstream of clustered ICAM-1 to increase RhoA activity, and that this pathway is further enhanced by mechanical force on ICAM-1. Depletion of LARG decreases leukocyte crawling and inhibits TEM. To our knowledge, this is the first report of endothelial LARG regulating leukocyte behavior and EC stiffening in response to tractional forces generated by leukocytes.
(1798) Margaret Caldwell (or Hope)
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Realization of a Tunable Artificial Atom at a Supercritically Charged Vacancy in Graphene
Creators: name: Mao, Jinhai
name: Jiang, Yuhang
name: Moldovan, Dean
name: Li, Guohong
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Masir, Massoud Ramezani
name: Peeters, Francois M.
name: Andrei, Eva Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The remarkable electronic properties of graphene have fueled the vision of a graphene-based platform for lighter, faster and smarter electronics and computing applications. One of the challenges is to devise ways to tailor its electronic properties and to control its charge carriers. Here we show that a single atom vacancy in graphene can stably host a local charge and that this charge can be gradually built up by applying voltage pulses with the tip of a scanning tunneling microscope (STM). The response of the conduction electrons in graphene to the local charge is monitored with scanning tunneling and Landau level spectroscopy, and compared to numerical simulations. As the charge is increased, its interaction with the conduction electrons undergoes a transition into a supercritical regime 6-11 where itinerant electrons are trapped in a sequence of quasi-bound states which resemble an artificial atom. The quasi-bound electron states are detected by a strong enhancement of the density of states (DOS) within a disc centered on the vacancy site which is surrounded by halo of hole states. We further show that the quasi-bound states at the vacancy site are gate tunable and that the trapping mechanism can be turned on and off, providing a new mechanism to control and guide electrons in graphene
description: 18 pages and 5 figures plus 14 pages and 15 figures of supplementary information. Nature Physics advance online publication, Feb 22 (2016)
Spectrum of the Supernova Relic Neutrino Background and Metallicity Evolution of Galaxies
Creators: name: Nakazato, Ken'ichiro
name: Mochida, Eri
name: Niino, Yuu
name: Suzuki, Hideyuki
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The spectrum of the supernova relic neutrino (SRN) background from past stellar collapses including black hole formation (failed supernovae) is calculated. The redshift dependence of the black hole formation rate is considered on the basis of the metallicity evolution of galaxies. Assuming the mass and metallicity ranges of failed supernova progenitors, their contribution to SRNs is quantitatively estimated for the first time. Using this model, the dependences of SRNs on the cosmic star formation rate density, shock revival time and equation of state are investigated. The shock revival time is introduced as a parameter that should depend on the still unknown explosion mechanism of core collapse supernovae. The dependence on equation of state is considered for failed supernovae, whose collapse dynamics and neutrino emission are certainly affected. It is found that the low-energy spectrum of SRNs is mainly determined by the cosmic star formation rate density. These low-energy events will be observed in the Super-Kamiokande experiment with gadolinium-loaded water.
description: 14 pages, 14 figures, accepted for publication in ApJ. The supernova relic neutrino data computed in this study are available at http://asphwww.ph.noda.tus.ac.jp/srn/
CD8 + T Cells Control Ross River Virus Infection in Musculoskeletal Tissues of Infected Mice
Creators: name: Burrack, Kristina S.
name: Montgomery, Stephanie A.
name: Morrison, Thomas E.
name: Homann, Dirk
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Ross River virus (RRV), chikungunya virus (CHIKV), and related alphaviruses cause debilitating polyarthralgia and myalgia. Mouse models of RRV and CHIKV have demonstrated a role for the adaptive immune response in the control of these infections. However, questions remain regarding the role for T cells in viral control, including the magnitude, location, and dynamics of CD8+ T cell responses. To address these questions, we generated a recombinant RRV expressing the H-2b-restricted gp33 determinant derived from the glycoprotein (gp) of lymphocytic choriomeningitis virus (LCMV) (“RRV-LCMV”). Utilizing tetramers, we tracked gp33-specific CD8+ T cells during RRV-LCMV infection. We found that acute RRV infection induces activation of CD8+ T cell responses in lymphoid and musculoskeletal tissues that peak from 10 to 14 days post-inoculation (dpi), suggesting that CD8+ T cells contribute to control of acute RRV infection. Mice genetically deficient for CD8+ T cells or wild-type mice depleted of CD8+ T cells had elevated RRV loads in skeletal muscle tissue, but not joint-associated tissues, at 14 dpi, suggesting that the ability of CD8+ T cells to control RRV infection is tissue-dependent. Finally, adoptively transferred T cells were capable of reducing RRV loads in skeletal muscle tissue of Rag1−/− mice, indicating that T cells can contribute to the control of RRV infection in the absence of B cells and antibody. Collectively, these data demonstrate a role for T cells in the control of RRV infection and suggest that the antiviral capacity of T cells is controlled in a tissue-specific manner.
Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection
Creators: name: Adler, Heiko
name: Ploegh, Hidde L.
name: Schattgen, Stefan A.
name: Sun, Ren
name: Jakobsen, Martin R.
name: Hilterbrand, Adam T.
name: Paludan, Søren R.
name: Pisitkun, Prapaporn
name: Hansen, Kathrine
name: Horan, Kristy A.
name: Damania, Blossom
name: Jorgensen, Joan P.
name: O'Hare, Peter
name: Sun, Chenglong
name: Upton, Jason W.
name: West, John A.
name: Wang, Lucas J.
name: Fitzgerald, Katherine A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infections. There is currently limited knowledge on viruses targeting the innate DNA sensing pathway and also on how the innate system impacts on the latent reservoir of herpesvirus infections. Here we report that murine gammaherpesvirus MHV68, in contrast to alpha- and beta-herpesviruses, induce very limited innate immune responses through DNA-stimulated pathways, which correspondingly played only a minor role in control of MHV68 infections in vivo. Similarly, Kaposi's sarcoma-associated herpesvirus also did not stimulate immune signaling through the DNA sensing pathways. Interestingly, a MHV68 mutant lacking the deubiquitinase (DUB) activity, embedded within the large tegument protein ORF64, gained the capacity to stimulate the DNA-activated STING pathway. We found that ORF64 targeted a step in the DNA-activated pathways upstream of the bifurcation into the STING and AIM2 pathways, and lack of the ORF64 DUB was associated with impaired delivery of viral DNA to the nucleus, which instead localized to the cytoplasm. Correspondingly, the ORF64 DUB active site mutant virus exhibited impaired ability to establish latent infection in wild type but not STING-deficient mice. Thus, gammaherpesviruses evade immune activation by the cytosolic DNA sensing pathway, which in the MHV68 model facilitates establishment of infections.
LES CELLULES GLANDULAIRES DES HYDROIDES ET DES HYDROMÉDUSES. LEUR STRUCTURE ET LA NATURE DE LEURS SÉCRÉTIONS
Creators: name: BOUILLON, Jean
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: Digestive gland cells of hydroids and hydromedusae have been studied from the view points of their histology, ultrastructure, and physiology.Various techniques have been employed to demonstrate the existence of three types of endodermal gland cells characteristic of all hydroid and hydromedusae groups.
Two of the types are localized principally in the hypostomal region of polyps and in the oral portion of the manubrium of the medusae.These types are known as hypostomal or oral spumous gland cells and hypostomal or oral spheru- lous gland cells. The third category of gland cells is found in the gastric column and stolon of polyps and also in the median and stomach regions of the manubrium of the medusae. To distinguish these cells they been designated spherulous stomach gland cells.
Besides these three types, certain polyps belonging to the super-families Ptero- nematoidea and Corynoidea possess a fourth category of gland cell, localized in the apical ectoderma of the hypostome. The name ectodermal spherulous stomach gland cells has been applied to this type of cell. The four types of gland cells differ not only in their morphology and ultra- structure, but also in the nature of their secretory products.
(1799) Alexander Stewart Morris
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Biodiversity and distribution of the Scolecida (Annelida: Polychaeta) on the continental shelf of the Gulf of California, Mexican Pacific
Creators: name: HERNÁNDEZ-ALCÁNTARA, Pablo
name: SOLÍS-WEISS, Vivianne
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The latitudinal and bathymetric distribution of the Scolecida (Polychaeta) clade species from the continental shelf of the Gulf of California are herein analysed. Eight families and 109 species were collected and identified in 53 localities from its northern, central and southern regions. The most diverse families were Capitellidae (32 species, 17 genera) and Orbiniidae (24 species, 4 genera). The localities with the highest biodiversity (> 12 species) are scattered along the Gulf. The classical north-south increasing biodiversity gradient was not observed since the number of species is similar in all three regions of the Gulf (78 to 83 species/region). Bathymetrically, a parabolic trend emerged, biased towards shallow depths. The highest number of species was found at 40 m depth (52 species), the lowest on the outer shelf, with a strong reduction in diversity from 140 m down (< 5 species). The updated and comprehensive list of species presented here includes the results of our research in the area complemented by all the literature records with their known distribution. This in particular constitutes an important tool for future taxonomical surveys, as well as ecological or biogeographical studies.
Cumacean density, biomass and productivity in the sandy bottoms of the Bay of Blanes (western Mediterranean)
Creators: name: CORBERA, Jordi
name: MARTIN, Daniel
name: PINEDO, Susana
name: SARDÁ, Rafael
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: During a study on seasonal dynamics and community structure of the sublittoral soft-bottom macroinfauna carried on from 1992 to 1997 in Bay of Blanes, ten cumacean species were collected. Density and biomass of Bodotria pulchella, Iphinoe douniae, Pseudocuma longicorne and Pseudocuma simile (the most frequent species) were calculated based on fortnightly samples, from March to September 1992. Bodotria pulchella showed the highest mean density (47.7 ind.m-2), while its mean biomass (AFDW) was 1.24 mg.m-2. Iphinoe douniae showed 35.3 ind.m-2 on average, but its mean biomass was higher than in B. pulchella (2.01 mg.m-2) due to its large size. The density and biomass trends varied independently among the four species. However, the corresponding trends for the whole community throughout the five years of study showed higher mean values of abundance and biomass during late spring/early summer. According to an empirical model, the secondary production for the four species ranged between 2.75 and 12.93 mg.m-2.yr-1, while the corresponding P/B ratio ranged between 7.1 and 10.8 year-1. Although high, these values do not differ from those previously reported for other suprabenthic crustacean populations.
IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors
Creators: name: Edwards, Andrew K.
name: Singh, Sukhbir S.
name: Ahn, Soo Hyun
name: Young, Steven L.
name: Lessey, Bruce A.
name: Tayade, Chandrakant
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neo-angiogenesis or establishment of new blood supply is one of the fundamental requirements of endometriotic lesion survival in the peritoneal cavity. IL-17A is emerging as a potent angiogenic and pro-inflammatory cytokine involved in the pathophysiology of several chronic inflammatory diseases such as rheumatoid arthritis and psoriasis. However, sparse information is available in the context of endometriosis. In this study, we demonstrate the potential importance of IL-17A in the pathogenesis and pathophysiology of endometriosis. The data show a differential expression of IL-17A in human ectopic endometriotic lesions and matched eutopic endometrium from women with endometriosis. Importantly, surgical removal of lesions resulted in significantly reduced plasma IL-17A concentrations. Immunohistochemistry revealed localization of IL-17A primarily in the stroma of matched ectopic and eutopic tissue samples. In vitro stimulation of endometrial epithelial carcinoma cells, Ishikawa cells and human umbilical vein endothelial cells with IL-17A revealed significant increase in angiogenic (VEGF, IL-8), pro-inflammatory (IL-6, IL-1β) and chemotactic cytokines (G-CSF, CXCL12, CXCL1, CX3CL1). Furthermore, IL-17A promoted tubulogenesis of HUVECs plated on matrigel in a dose-dependent manner. Thus we provide the first evidence that endometriotic lesions produce IL-17A and that the removal of the lesion via laparoscopic surgery leads to the significant reduction in the systemic levels of IL-17A. Taken together, our data shows a likely important role of IL-17A in promoting angiogenesis and pro-inflammatory environment in the peritoneal cavity for the establishment and maintenance of endometriosis lesions.
Interest-Based Access Control for Content Centric Networks (extended version)
Creators: name: Ghali, Cesar
name: Schlosberg, Marc A.
name: Tsudik, Gene
name: Wood, Christopher A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Content-Centric Networking (CCN) is an emerging network architecture designed to overcome limitations of the current IP-based Internet. One of the fundamental tenets of CCN is that data, or content, is a named and addressable entity in the network. Consumers request content by issuing interest messages with the desired content name. These interests are forwarded by routers to producers, and the resulting content object is returned and optionally cached at each router along the path. In-network caching makes it difficult to enforce access control policies on sensitive content outside of the producer since routers only use interest information for forwarding decisions. To that end, we propose an Interest-Based Access Control (IBAC) scheme that enables access control enforcement using only information contained in interest messages, i.e., by making sensitive content names unpredictable to unauthorized parties. Our IBAC scheme supports both hash- and encryption-based name obfuscation. We address the problem of interest replay attacks by formulating a mutual trust framework between producers and consumers that enables routers to perform authorization checks when satisfying interests from their cache. We assess the computational, storage, and bandwidth overhead of each IBAC variant. Our design is flexible and allows producers to arbitrarily specify and enforce any type of access control on content, without having to deal with the problems of content encryption and key distribution. This is the first comprehensive design for CCN access control using only information contained in interest messages.
description: 11 pages, 2 figures
Von der Wissenschaftssoziologie zur Soziologie wissenschaftlichen Wissens
Creators: name: Niewöhner, Jörg
Publisher: name: Humboldt-Universität zu Berlin
Year: 2012
Subjects: subject: 300 Sozialwissenschaften
subject: 301 Soziologie, Anthropologie
subject: 907 Ausbildung, Forschung, verwandte Themen

description: Robert K. Merton begründete in den 1930 und 40er Jahren die Wissenschaftssoziologie mit seinen Untersuchungen über die Entwicklung der Wissenschaft im England des 17. Jahrhunderts und ihren wechselseitigen Zusammenhang mit gesellschaftlichen Entwicklungen, speziell dem Puritanismus. Wissenschaft wird durch diesen Forschungsansatz als Institution bzw. als Organisation erstmals Untersuchungen durch die Sozialwissenschaften zugänglich. Aus diesem Verständnis von Wissenschaft heraus entwickelt Merton seine Imperative des wissenschaftlichen Ethos: Universalität, Kommunismus, Uneigennützigkeit und organisierter Skeptizismus. Die Wissenschaftssoziologie der Nachkriegszeit wird vor allen Dingen von immer neuen Angriffen auf diesen Ethos und Vereinnahmungsversuchen der Wissenschaft durch politische und wirtschaftliche Interessen geprägt. Die Technokratiedebatte und der Positivismusstreit in Deutschland, und die Untersuchungen und Streitschriften für wissenschaftliche Unabhängigkeit eines Michael Polanyi oder Jerry Ravetz in der anglo-amerikanischen Soziologie, sind so immer Ausdruck einer grundlegenden und hart geführten Debatte über Erkenntnismöglichkeiten in konkreten sozialen Institutionen. Nicht gestellt wird die Frage nach den Auswirkungen von institutionellem Wandel auf Wissen selbst. Dies ist das entscheidende Forschungsdesiderat, dessen sich die Science and Technology Studies in den 1970er Jahren annehmen: sie überführen die Wissenschaftssoziologie und ihre Untersuchungen von Wissenschaft als Institution in eine Soziologie wissenschaftlichen Wissens und machen damit Wissen selbst zum Untersuchungsgegenstand sozialwissenschaftlicher Forschung.
Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice
Creators: name: Rebeles, Jenny
name: Milner, J. Justin
name: Stewart, Delisha A.
name: Beck, Melinda A.
name: Meyers, Matthew H.
name: Sumner, Susan C.J.
name: Mancuso, Peter
name: Dhungana, Suraj
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pandemic H1N1 influenza virus (pH1N1). In this study, diet-induced and genetic-induced obese mouse models were utilized to uncover potential mechanisms by which obesity increases pH1N1 severity. High fat diet-induced and genetic-induced obese mice exhibited greater pH1N1 mortality, lung inflammatory responses and excess lung damage despite similar levels of viral burden compared with lean control mice. Further, obese mice had fewer bronchoalveolar macrophages and regulatory T cells during infection. Obesity is inherently a metabolic disease, and metabolic profiling has found widespread usage in metabolic and infectious disease models for identifying biomarkers and enhancing understanding of complex mechanisms of disease. To further characterize the consequences of obesity on pH1N1 infection responses, we performed global liquid chromatography-mass spectrometry metabolic profiling of lung tissue and urine. An array of metabolites were perturbed by obesity both prior to and during infection. Uncovered metabolic signatures were used to identify changes in metabolic pathways that were differentially altered in the lungs of obese mice such as fatty acid, phospholipid, and nucleotide metabolism. Taken together, obesity induces distinct alterations in the lung metabolome, perhaps contributing to aberrant pH1N1 immune responses.
Additional file 4 of A qualitative study of how clinicians reach agreement in perioperative pathway development: the Consensus Model for Standardising Healthcare
Creators: name: Pagano, Lisa
name: Long, Janet C.
name: Francis-Auton, Emilie
name: Hirschhorn, Andrew
name: Arnolda, Gaston
name: Braithwaite, Jeffrey
name: Sarkies, Mitchell N.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Supplementary Material 4. Topic guide for semi structured interviews utilised for leadership or management staff, (.pdf). Provides the topic guide initially piloted by the research team and used to guide the interviewer in the semi-structured interviews for clinicians.