cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Glecaprevir and pibrentasvir for 12 weeks for hepatitis C virus genotype 1 infection and prior direct-acting antiviral treatment: Poordad et al.
Creators: name: Felizarta, Franco
name: Lovell, Sandra S.
name: Bernstein, David E.
name: Reindollar, Robert W.
name: Sulkowski, Mark S.
name: Gordon, Stuart C.
name: Asatryan, Armen
name: Ng, Teresa I.
name: Poordad, Fred
name: Landis, Charles S.
name: Fried, Michael W.
name: Flamm, Steven L.
name: Lin, Chih-Wei
name: Liu, Ran
name: Kort, Jens
name: Mensa, Federico J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Although direct‐acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection have demonstrated high rates of sustained virologic response, virologic failure may still occur, potentially leading to the emergence of viral resistance, which can decrease the effectiveness of subsequent treatment. Treatment options for patients who failed previous DAA‐containing regimens, particularly those with nonstructural protein 5A inhibitors, are limited and remain an area of unmet medical need. This phase 2, open‐label study (MAGELLAN‐1) evaluated the efficacy and safety of glecaprevir (GLE) + pibrentasvir (PIB) ± ribavirin (RBV) in HCV genotype 1–infected patients with prior virologic failure to HCV DAA‐containing therapy. A total of 50 patients without cirrhosis were randomized to three arms: 200 mg GLE + 80 mg PIB (arm A), 300 mg GLE + 120 mg PIB with 800 mg once‐daily RBV (arm B), or 300 mg GLE + 120 mg PIB without RBV (arm C). By intent‐to‐treat analysis, sustained virologic response at posttreatment week 12 was achieved in 100% (6/6, 95% confidence interval 61‐100), 95% (21/22, 95% confidence interval 78‐99), and 86% (19/22, 95% confidence interval 67‐95) of patients in arms A, B, and C, respectively. Virologic failure occurred in no patients in arm A and in 1 patient each in arms B and C (two patients were lost to follow‐up in arm C). The majority of adverse events were mild in severity; no serious adverse events related to study drug and no relevant laboratory abnormalities in alanine aminotransferase, total bilirubin, or hemoglobin were observed. Conclusion: The combination of GLE and PIB was highly efficacious and well tolerated in patients with HCV genotype 1 infection and prior failure of DAA‐containing therapy; RBV coadministration did not improve efficacy. (Hepatology 2017;66:389–397).
Application of the Compress Sensing Theory for Improvement of the TOF Resolution in a Novel J-PET Instrument
Creators: name: Raczynski, L.
name: Moskal, P.
name: Kowalski, P.
name: Wislicki, W.
name: Bednarski, T.
name: Bialas, P.
name: Czerwinski, E.
name: Gajos, A.
name: Kaplon, L.
name: Kochanowski, A.
name: Korcyl, G.
name: Kowal, J.
name: Kozik, T.
name: Krzemien, W.
name: Kubicz, E.
name: Niedzwiecki, Sz.
name: Palka, M.
name: Rudy, Z.
name: Salabura, P.
name: Sharma, N. G.
name: Silarski, M.
name: Slomski, A.
name: Smyrski, J.
name: Strzelecki, A.
name: Wieczorek, A.
name: Zielinski, M.
name: Zon, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Nowadays, in Positron Emission Tomography (PET) systems, a Time of Flight information is used to improve the image reconstruction process. In Time of Flight PET (TOF-PET), fast detectors are able to measure the difference in the arrival time of the two gamma rays, with the precision enabling to shorten significantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to Compress Sensing theory, information about the shape and amplitude of the signals is recovered. In this paper we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50 ps intervals. Experimental setup provided irradiation of a chosen position in the plastic scintillator strip with annihilation gamma quanta.
A practice-led assessment of landscape restoration potential in a biodiversity hotspot: Supplementary Material
Creators: name: Wills, Abigail R.
name: Marshall, Andrew R.
name: Shirima, Deo D.
name: Villemaire-Côté, Olivier
name: Platts, Philip J.
name: Knight, Sarah J.
name: Loveridge, Robin
name: Seki, Hamidu
name: Waite, Catherine E.
name: Munishi, Pantaleo K. T.
name: Lyatuu, Herman
name: Bernal, Blanca
name: Pfeifer, Marion
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Effective restoration planning tools are needed to mitigate global carbon and biodiversity crises. Published spatial assessments of restoration potential are often at large scales or coarse resolutions inappropriate for local action. Using a Tanzanian case study, we introduce a systematic approach to inform landscape restoration planning, estimating spatial variation in cost-effectiveness, based on restoration method, logistics, biomass modelling and uncertainty mapping. We found potential for biomass recovery across 77.7% of a 53 000 km2 region, but with some natural spatial discontinuity in moist forest biomass, that was previously assigned to human causes. Most areas with biomass deficit (80.5%) were restorable through passive or assisted natural regeneration. However, cumulative biomass gains from planting outweighed initially high implementation costs meaning that, where applicable, this method yielded greater long-term returns on investment. Accounting for ecological, funding and other uncertainty, the top 25% consistently cost-effective sites were within protected areas and/or moderately degraded moist forest and savanna. Agro-ecological mosaics had high biomass deficit but little cost-effective restoration potential. Socio-economic research will be needed to inform action towards environmental and human development goals in these areas. Our results highlight value in long-term landscape restoration investments and separate treatment of savannas and forests. Furthermore, they contradict previously asserted low restoration potential in East Africa, emphasizing the importance of our regional approach for identifying restoration opportunities across the tropics.This article is part of the theme issue ‘Understanding forest landscape restoration: reinforcing scientific foundations for the UN Decade on Ecosystem Restoration’.
Revivals in Quantum Walks with quasi-periodically time-dependent coin
Creators: name: Cedzich, C.
name: Werner, R. F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We provide an explanation of recent experimental results of Xue et al., where full revivals in a time-dependent quantum walk model with a periodically changing coin are found. Using methods originally developed for "electric" walks with a space-dependent, rather than a time-dependent coin, we provide a full explanation of the observations of Xue et al. We extend the analysis from periodic time-dependence to quasi-periodic behaviour with periods incommensurate to the step size. Spectral analysis, one of the principal tools for the study of electric walks, fails for time-dependent systems, but we find qualitative propagation behaviour of the time-dependent system in close analogy to the electric case.
description: 6 pages, 3 figures
Oratio pro Ctesiphonte de corona, mit den Varianten der Übersetzung von Nicolaus Secundinus
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1500

description: Demosthenes
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Monfasani. John. - George of Trebizond, a biography and a study of his rhetoric and logic (Columbia studies in the classical tradition, 1). - Leiden, 1976, S. 66 Anm. 165, 379f. (Abdruck) (Bezug auf 42v-43r)
description: Verzeichnung=Description=Inventaire Jan. 2010 Titel, Jahr und Signatur nach: Steinmann, unpublizierte Beschreibung
description: Erschliessungsniveau Kurzeintrag
description: Digitalisierung=Digitization=Numérisation Juni 2023 TIFF
A practice-led assessment of landscape restoration potential in a biodiversity hotspot: Supplementary Material
Creators: name: Wills, Abigail R.
name: Marshall, Andrew R.
name: Shirima, Deo D.
name: Villemaire-Côté, Olivier
name: Platts, Philip J.
name: Knight, Sarah J.
name: Loveridge, Robin
name: Seki, Hamidu
name: Waite, Catherine E.
name: Munishi, Pantaleo K. T.
name: Lyatuu, Herman
name: Bernal, Blanca
name: Pfeifer, Marion
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Effective restoration planning tools are needed to mitigate global carbon and biodiversity crises. Published spatial assessments of restoration potential are often at large scales or coarse resolutions inappropriate for local action. Using a Tanzanian case study, we introduce a systematic approach to inform landscape restoration planning, estimating spatial variation in cost-effectiveness, based on restoration method, logistics, biomass modelling and uncertainty mapping. We found potential for biomass recovery across 77.7% of a 53 000 km2 region, but with some natural spatial discontinuity in moist forest biomass, that was previously assigned to human causes. Most areas with biomass deficit (80.5%) were restorable through passive or assisted natural regeneration. However, cumulative biomass gains from planting outweighed initially high implementation costs meaning that, where applicable, this method yielded greater long-term returns on investment. Accounting for ecological, funding and other uncertainty, the top 25% consistently cost-effective sites were within protected areas (PA) and/or moderately degraded moist forest and savanna. Agro-ecological mosaics had high biomass deficit but little cost-effective restoration potential. Socio-economic research will be needed to inform action towards environmental and human development goals in these areas. Our results highlight value in long-term landscape restoration investments and separate treatment of savannas and forests. Furthermore, they contradict previously asserted low restoration potential in East Africa, emphasizing the importance of our regional approach for identifying restoration opportunities across the tropics.This article is part of the theme issue ‘Understanding forest landscape restoration: reinforcing scientific foundations for the UN Decade on Ecosystem Restoration’.
New therapeutic targets in alcoholic hepatitis
Creators: name: Farooq, Omar
name: Arsene, Diana
name: Bataller, Ramon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Alcoholic liver disease (ALD) is a leading cause of liver related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute on chronic state of alcoholic hepatitis. While multidisciplinary efforts continue to be aimed at curbing progression of this spectrum of disorders, there is an urgent need to focus our efforts on effective therapeutic interventions for alcoholic hepatitis (AH), the most severe form of ALD. AH is characterized by an abrupt development of jaundice and complications related to liver insufficiency and portal hypertension in patients with heavy alcohol intake. The mortality of patients with severe AH is very high (20–50% at 3 months). The current therapeutic regimens are limited. The development of new therapies requires translational studies in human samples and suitable animal models that reproduce clinical and histological features of human AH. This review article summarizes the clinical syndrome, pre-clinical translational tools, and pathogenesis of AH at a molecular and cellular level, with the aim to identify new targets of potential therapeutic intervention.
Opening the band gap of graphene through silicon doping for improved performance of graphene/GaAs heterojunction solar cells
Creators: name: Zhang, Shengjiao
name: Lin, Shisheng
name: Li, Xiaoqiang
name: Liu, Xiaoyi
name: Wu, Hengan
name: Wang, Peng
name: Wu, Zhiqian
name: Zhong, Huikai
name: Xu, Wenli
name: Xu, Zhijuan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Graphene has attracted increasing interests due to its remarkable properties, however, the zero band gap of monolayer graphene might limit its further electronic and optoelectronic applications. Herein, we have successfully synthesized monolayer silicon-doped graphene (SiG) in large area by chemical vapor deposition method. Raman spectroscopy and X-ray photoelectron spectroscopy measurements evidence silicon atoms are doped into graphene lattice with the doping level of 3.4 at%. The electrical measurement based on field effect transistor indicates that the band gap of graphene has been opened by silicon doping, which is around 0. 28 eV supported by the first-principle calculations, and the ultraviolet photoelectron spectroscopy demonstrates the work function of SiG is 0.13 eV larger than that of graphene. Moreover, the SiG/GaAs heterostructure solar cells show an improved power conversion efficiency of 33.7% in average than that of graphene/GaAs solar cells, which are attributed to the increased barrier height and improved interface quality. Our results suggest silicon doping can effectively engineer the band gap of monolayer graphene and SiG has great potential in optoelectronic device applications.
On the Complexity of Inner Product Similarity Join
Creators: name: Ahle, Thomas D.
name: Pagh, Rasmus
name: Razenshteyn, Ilya
name: Silvestri, Francesco
Publisher: name: arXiv
Year: 2015
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Databases (cs.DB)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: A number of tasks in classification, information retrieval, recommendation systems, and record linkage reduce to the core problem of inner product similarity join (IPS join): identifying pairs of vectors in a collection that have a sufficiently large inner product. IPS join is well understood when vectors are normalized and some approximation of inner products is allowed. However, the general case where vectors may have any length appears much more challenging. Recently, new upper bounds based on asymmetric locality-sensitive hashing (ALSH) and asymmetric embeddings have emerged, but little has been known on the lower bound side. In this paper we initiate a systematic study of inner product similarity join, showing new lower and upper bounds. Our main results are: * Approximation hardness of IPS join in subquadratic time, assuming the strong exponential time hypothesis. * New upper and lower bounds for (A)LSH-based algorithms. In particular, we show that asymmetry can be avoided by relaxing the LSH definition to only consider the collision probability of distinct elements. * A new indexing method for IPS based on linear sketches, implying that our hardness results are not far from being tight. Our technical contributions include new asymmetric embeddings that may be of independent interest. At the conceptual level we strive to provide greater clarity, for example by distinguishing among signed and unsigned variants of IPS join and shedding new light on the effect of asymmetry.
description: in Proc. 35th ACM Symposium on Principles of Database Systems, 2016
Classification of stable Dirac and Weyl semimetals with reflection and rotational symmetry
Creators: name: Gao, Zihao
name: Hua, Meng
name: Zhang, Haijun
name: Zhang, Xiao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Three dimensional (3D) Dirac semimetal is a novel state of quantum matter, characterized by the gapless bulk four-fold degeneracy near Fermi energy. Soon after its discovery, the classification of stable 3D Dirac semimetals with inversion and rotational symmetry have been studied. However, only ten out of thirty-two point groups have both inversion and rotational symmetry, and we need a more complete classification of stable 3D Dirac semimetals. Here we classify stable 3D Dirac semimetals with reflection symmetry and rotational symmetry in the presence of time reversal symmetry, which belong to seventeen different point groups. These systems include the systems preserving inversion symmetry except $\mathrm{C_{3i}}$. They have two classes of reflection symmetry, with the mirror plane parallel to rotation axis and the mirror plane perpendicular to rotation axis. In both cases two types of Dirac semimetals are determined by four different reflection symmetries. The first type of Dirac semimetals will appear through accidental band crossing (ABC). The second type of Dirac semimetals have a Dirac point at a time reversal invariant momentum (TBC). We show that in both mirror parallel and perpendicular cases, $C_{2,3}$ symmetry can only protect stable Dirac points via TBC, while $C_{4,6}$ symmetry can have stable Dirac points as ABC or TBC. We further discuss that Weyl line nodes and Dirac semimetal can exist in Brillouin zone at the same time using $\mathrm{C_{4v}}$ symmetry as an example. Finally we classify Dirac line nodes and Weyl line nodes to show in which types of mirror plane they can exist.
description: 11 pages, 3 figures
Analysis of Fermi gamma-ray burst duration distribution
Creators: name: Tarnopolski, Mariusz
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Two classes of GRBs, short and long, have been determined without any doubts, and are usually prescribed to different physical scenarios. A third class, intermediate in $T_{90}$ durations, has been reported to be present in the datasets of BATSE, Swift, RHESSI and possibly BeppoSAX. The latest release of $>1500$ GRBs observed by Fermi gives an opportunity to further investigate the duration distribution. The aim of this paper is to investigate whether a third class is present in the $\log T_{90}$ distribution, or is it described by a bimodal distribution. A standard $χ^2$ fitting of a mixture of Gaussians is applied to 25 histograms with different binnings. Different binnings give various values of the fitting parameters, as well as the shape of the fitted curve. Among five statistically significant fits none is trimodal. Locations of the Gaussian components are in agreement with previous works. However, a trimodal distribution, understood in the sense of having three separated peaks, is not found for any binning. It is concluded that the duration distribution in Fermi data is well described by a mixture of three log-normal distributions, but it is intrinsically bimodal, hence no third class is present in the $T_{90}$ data of Fermi. It is suggested that the log-normal fit may not be an adequate model.
description: 6 pages, 3 figures; matches the version to be published
Creating a Semantic Catalogue of Architectural Drawings
Creators: name: Hauschke, Christian
name: Rubach, Birte
name: Triggs, Graham
name: Walther, Tatiana
Publisher: name: Zenodo
Year: 2021
Subjects: Vitro
art historical collection
Albrecht Haupt
semantic catalogue
vivo2021

description: In 2020, TIB started a project to put the “Albrecht Haupt Collection” online, as part of a tool for creating reusable metadata about the collection. It started with the digitisation as high resolution images of the physical collection into a Goobi repository. In this presentation, we will detail the architecture, customisations and data flow, that enables us to serve high resolution, zoomable, images embedded within a Vitro user interface. An interface that allows researchers to browse the collection, whilst enriching the metadata of the collection.
The initial mass functions of M31 and M32 through far red stellar absorption features
Creators: name: Zieleniewski, Simon
name: Houghton, Ryan C. W.
name: Thatte, Niranjan
name: Davies, Roger L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using the Oxford Short Wavelength Integral Field specTrograph (SWIFT), we investigate radial variations of several initial mass function (IMF) dependent absorption features in M31 and M32. We obtain high signal-to-noise spectra at six pointings along the major axis of M31 out to ~ 700" (2.7 kpc) and a single pointing of the central 10 pc for M32. In M31 the sodium NaI λ8190 index shows a flat equivalent width profile at ~ 0.4 Å through the majority of the bulge, with a strong gradient up to 0.8 Å in the central 10" (38 pc); the Wing-Ford FeH λ9916 index is measured to be constant at 0.4 Å for all radii; and calcium triplet CaT λ8498, 8542, 8662 shows a gradual increase through the bulge towards the centre. M32 displays flat profiles for all three indices, with FeH at ~ 0.5 Å, very high CaT at ~ 0.8 Å and low NaI at ~ 0.1 Å. We analyse these data using stellar population models. We find that M31 is well described on all scales by a Chabrier IMF, with a gradient in sodium enhancement of [Na/Fe] ~ +0.3 dex in the outer bulge, rising within the central 10" to perhaps [Na/Fe] ~ +1.0 dex in the nuclear region. We find M32 is described by a Chabrier IMF and young stellar age in line with other studies. Models show that CaT is much more sensitive to metallicity and [α/Fe] than to IMF. We note that the centres of M31 and M32 have very high stellar densities and yet we measure Chabrier IMFs in these regions.
description: 11 pages, 9 figures, accepted for publication in MNRAS. Updated Figs. 5 & A4 after feedback from F. La Barbera, I. Ferreras & A Vazdekis
Mortality among Tennessee Eastman Corporation (TEC) uranium processing workers, 1943–2019
Creators: name: Boice, John D.
name: Cohen, Sarah S.
name: Mumma, Michael T.
name: Golden, Ashley P.
name: Howard, Sara C.
name: Girardi, David J.
name: Ellis, Elizabeth D.
name: Bellamy, Michael B.
name: Dauer, Lawrence T.
name: Eckerman, Keith F.
name: Leggett, Richard W.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Biotechnology
Cancer

description: There are few occupational studies of women exposed to ionizing radiation. During World War II, the Tennessee Eastman Corporation (TEC) operated an electromagnetic field separation facility of 1152 calutrons to obtain enriched uranium (235U) used for the Hiroshima atomic bomb. Thousands of women were involved in these operations. A new study was conducted of 13,951 women and 12,699 men employed at TEC between 1943 and 1947 for at least 90 days. Comprehensive dose reconstruction techniques were used to estimate lung doses from the inhalation of uranium dust based on airborne measurements. Vital status through 2018/2019 was obtained from the National Death Index, Social Security Death Index, Tennessee death records and online public record databases. Analyses included standardized mortality ratios (SMRs) and Cox proportional hazards models. Most workers were hourly (77.7%), white (95.6%), born before 1920 (58.3%), worked in dusty environments (57.0%), and had died (94.9%). Vital status was confirmed for 97.4% of the workers. Women were younger than men when first employed: mean ages 25.0 years and 33.0 years, respectively. The estimated mean absorbed dose to the lung was 32.7 mGy (max 1048 mGy) for women and 18.9 mGy (max 501 mGy) for men. The mean dose to thoracic lymph nodes (TLNs) was 127 mGy. Statistically significant SMRs were observed for lung cancer (SMR 1.25; 95% CI 1.19, 1.31; n = 1654), nonmalignant respiratory diseases (NMRDs) (1.23; 95% CI 1.19, 1.28; n = 2585), and cerebrovascular disease (CeVD) (1.13; 95% CI 1.08, 1.18; n = 1945). For lung cancer, the excess relative rate (ERR) at 100 mGy (95% CI) was 0.01 (–0.10, 0.12; n = 652) among women, and −0.15 (–0.38, 0.07; n = 1002) among men based on a preferred model for men with lung doses <300 mGy. NMRD and non-Hodgkin lymphoma were not associated with estimated absorbed dose to the lung or TLN. There was little evidence that radiation increased the risk of lung cancer, suggesting that inhalation of uranium dust and the associated high-LET alpha particle exposure to lung tissue experienced over a few years is less effective in causing lung cancer than other types of exposures. There was no statistically significant difference in the lung cancer risk estimates between men and women. The elevation of certain causes of death such as CeVD is unexplained and will require additional scrutiny of workplace or lifestyle factors given that radiation is an unlikely contributor since only the lung and lymph nodes received appreciable dose.
DBRepo: A Database Repository to Support Research
Creators: name: Weise, Martin
name: Staudinger, Moritz
name: Michlits, Cornelia
name: Gergely, Eva
name: Stytsenko, Kirill
name: Taha, Josef
name: Ganguly, Raman
name: Rauber, Andreas
Publisher: name: Zenodo
Year: 2022

description: Poster as presented on the EGI 2022 conference held in Prague, Czech Republic.
Subcortical connections of the perirhinal, postrhinal, and entorhinal cortices of the rat. I. afferents: SUBCORTICAL AFFERENTS OF PERIRHINAL, POSTRHINAL, AND ENTORHINAL CORTICES
Creators: name: Agster, Kara L.
name: Tomás Pereira, Inês
name: Burwell, Rebecca D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In this study we characterized the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA). We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and densities of labeled cells in 36 subcortical structures and nuclei distributed across septum, basal ganglia, claustrum, amygdala, olfactory structures, thalamus, and hypothalamus. We found that the complement of subcortical inputs differs across the five regions, especially the PER and POR. The PER receives input from the reuniens, suprageniculate, and medial geniculate thalamic nuclei as well as the amygdala. Overall, the subcortical inputs to the PER are consistent with a role in perception, multimodal processing, and the formation of associations that include the motivational significance of individual items and objects. Subcortical inputs to the POR were dominated by the dorsal thalamus, particularly the lateral posterior nucleus, a region implicated in visuospatial attention. The complement of subcortical inputs to the POR is consistent with a role in representing and monitoring the local spatial context. We also report that, in addition to the PER, the LEA and the medial band of the MEA also receive strong amygdala input. In contrast, subcortical input to the POR and the MEA lateral band includes much less amygdala input and is dominated by dorsal thalamic nuclei, particularly nuclei involved in spatial information processing. Like the cortical inputs, the patterns of subcortical inputs to these regions are consistent both with the view that the dorsal hippocampus is important for spatial cognition and the ventral hippocampus is important for affective cognition, and the view that they provide considerable functional integration. We conclude that the patterns of subcortical inputs to the PER, POR, and the entorhinal LEA and MEA provide further evidence for functional differentiation in the medial temporal lobe.
Combination of PAKs inhibitors IPA-3 and PF-3758309 effectively suppresses colon carcinoma cell growth by perturbing DNA damage response
Creators: name: Dukel, Muzaffer
name: Fiskin, Kayahan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: PAKs proteins are speculated as new promising targets for cancer therapy due to their central role in many oncogenic pathways. Because PAKs proteins are very significant during carcinogenesis, we aimed to investigate the hypothesis that inhibition of PAKs with IPA-3 and PF-3758309 treatment could synergistically reduce colon carcinoma cell growth. The cytotoxic effects of both drugs were determined by a cell viability assay. Cell cycle and apoptosis were analyzed by flow cytometry. The effects of inhibitor drugs on marker genes of apoptosis, autophagy, cell cycle, and DNA damage were tested via immunoblotting. We found out the synergistic effect of these drugs in pair on five colon cancer cell lines. Combined treatment with IPA-3+PF-3758309 in SW620 and Colo 205 cells markedly suppressed colon formation and induced apoptosis, cell cycle arrest, and autophagy compared with treatment with each drug alone. Additionally, this combination sensitized colon cancer cells to ionizing radiation that resulted in inhibition of cell growth. Collectively, our findings show for the first time that cotreatment of IPA-3 with PF-3758309 exhibits superior inhibitory effects on colon carcinoma cell growth via inducing DNA damage-related cell death and also enforces a cell cycle arrest.
Optical-NIR spectroscopy of the puzzling gamma-ray source 3FGL 1603.9-4903/PMN J1603-4904 with X-shooter
Creators: name: Goldoni, P.
name: Pita, S.
name: Boisson, C.
name: Mueller, C.
name: Dauser, T.
name: Jung, I.
name: Krauss, F.
name: Lenain, J. -P.
name: Sol, H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Fermi/LAT instrument has detected about two thousands Extragalactic High Energy (E > 100 MeV) gamma-ray sources. One of the brightest is 3FGL 1603.9-4903, associated to the radio source PMN J1603-4904. Its nature is not yet clear, it could be either a very peculiar BL Lac or a CSO (Compact Symmetric Object) radio source, considered as the early stage of a radio galaxy. The latter, if confirmed, would be the first detection in gamma-rays for this class of objects. Recently a redshift z=0.18 +/- 0.01 has been claimed on the basis of the detection of a single X-ray line at 5.44 +/- 0.05 keV interpreted as a 6.4 keV (rest frame) fluorescent line. We aim to investigate the nature of 3FGL 1603.9-4903/PMN J1603-4904 using optical to NIR spectroscopy. We observed PMN J1603-4904 with the UV-NIR VLT/X-shooter spectrograph for two hours. We extracted spectra in the VIS and NIR range that we calibrated in flux and corrected for telluric absorption and we systematically searched for absorption and emission features. The source was detected starting from ~6300 Ang down to 24000 Ang with an intensity comparable to the one of its 2MASS counterpart and a mostly featureless spectrum. The continuum lacks absorption features and thus is non-stellar in origin and likely non-thermal. On top of this spectrum we detected three emission lines that we interpret as the Halpha-[NII] complex, the [SII] 6716,6731 doublet and the [SIII] 9530 line, obtaining a redshift estimate of z= 0.2321 +/- 0.0004. The equivalent width of the Halpha-[NII] complex implies that PMN J1603-4904 does not follow the observational definition of BL Lac, the line ratios suggest that a LINER/Seyfert nucleus is powering the emission. This new redshift measurement implies that the X-ray line previously detected should be interpreted as a 6.7 keV line which is very peculiar.
description: Published in Astronomy and Astrophysics
Molecular Valves for Controlling Gas Phase Transport Made from Discrete Angstrom-Sized Pores in Graphene
Creators: name: Wang, Luda
name: Drahushuk, Lee W.
name: Cantley, Lauren
name: Koenig, Steven P.
name: Liu, Xinghui
name: Pellegrino, John
name: Strano, Michael S.
name: Bunch, J. Scott
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: An ability to precisely regulate the quantity and location of molecular flux is of value in applications such as nanoscale 3D printing, catalysis, and sensor design. Barrier materials containing pores with molecular dimensions have previously been used to manipulate molecular compositions in the gas phase, but have so far been unable to offer controlled gas transport through individual pores. Here, we show that gas flux through discrete angstrom-sized pores in monolayer graphene can be detected and then controlled using nanometer-sized gold clusters, which are formed on the surface of the graphene and can migrate and partially block a pore. In samples without gold clusters, we observe stochastic switching of the magnitude of the gas permeance, which we attribute to molecular rearrangements of the pore. Our molecular valves could be used, for example, to develop unique approaches to molecular synthesis that are based on the controllable switching of a molecular gas flux, reminiscent of ion channels in biological cell membranes and solid state nanopores.
description: to appear in Nature Nanotechnology
Vacuum space-times with controlled singularities and without symmetries
Creators: name: Chruściel, Piotr T.
name: Klinger, Paul
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a family of four-dimensional vacuum space-times with asymptotically velocity dominated singularities and without symmetries.
description: 4 pages, minor misprints corrected, added comment that the result holds in vacuum for all values of the cosmological constant
Red-light radiation: Does it enhance memory by increasing hippocampal LRP-1 and TRPA-1 genes expression?
Creators: name: Haghjoo, Saereh
name: Hedayati, Mojtaba
name: Rostampour, Mohammad
name: Taleghani, Behrooz Khakpour-
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Despite the extensive efforts to treat the leading cause of neurodegenerative diseases (ND), a little progress has been reported. Red light might affect ND through many specific mechanisms. The purpose of this investigation is to explore the effect of red light on the expression of low-density lipoprotein receptor-1 (LRP-1) and transient receptor potential ankyrin-1 (TRPA-1) gene in the hippocampus, and the serum melatonin level (SML) of the LPS-induced neuro-inflammated rats. Red-light therapy was implemented using a wavelength 630 nm under different light conditions and the passive avoidance (PA) and Y-Maze tests were employed to assess memory performance. To evaluate the LRP-1 and TRPA-1 genes expression, q-RT-PCR was performed. To measure the SML, ELISA was performed before and after the red-light radiation. Lipopolysaccharide (LPS) caused memory impairment in both behavioral tests. Red-light therapy improved PA memory in all light conditions (p < 0.001). However, in Y-maze, only the red-light radiation during light and dark cycles, improved memory (p < 0.01and p < 0.001, respectively). In addition, red-light radiation caused significant increase in SML (P < 0.05). The LRP-1 and TRPA-1 genes expression increased significantly during the dark phase in the red light radiated group compared to non-radiated group (P < 0.001). Taken together, the results suggest that red-light therapy can reduce the complications of memory impairment in rats. This study has found that red-light therapy demonstrates higher effect during the period of dark phase compared to light phase. No doubt, further experimental studies would help us to establish a greater degree of accuracy on this matter.
The Role of Medial Temporal Lobe Regions in Incidental and Intentional Retrieval of Item and Relational Information in Aging: Medial Temporal Lobes in Aging and Memory
Creators: name: Giovanello, Kelly S.
name: Wang, Wei-Chun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Considerable neuropsychological and neuroimaging work indicates that the medial temporal lobes are critical for both item and relational memory retrieval. However, there remain outstanding issues in the literature, namely the extent to which medial temporal lobe regions are differentially recruited during incidental and intentional retrieval of item and relational information, and the extent to which aging may affect these neural substrates. The current fMRI study sought to address these questions; participants incidentally encoded word pairs embedded in sentences and incidental item and relational retrieval were assessed through speeded reading of intact, rearranged, and new word-pair sentences, while intentional item and relational retrieval were assessed through old/new associative recognition of a separate set of intact, rearranged, and new word pairs. Results indicated that, in both younger and older adults, anterior hippocampus and perirhinal cortex indexed incidental and intentional item retrieval in the same manner. In contrast, posterior hippocampus supported incidental and intentional relational retrieval in both age groups and an adjacent cluster in posterior hippocampus was recruited during both forms of relational retrieval for older, but not younger, adults. Our findings suggest that while medial temporal lobe regions do not differentiate between incidental and intentional forms of retrieval, there are distinct roles for anterior and posterior medial temporal lobe regions during retrieval of item and relational information, respectively, and further indicate that posterior regions may, under certain conditions, be over-recruited in healthy aging.
Neurocognitive and radiological changes after cranial radiation therapy in humans and rodents: A systematic review
Creators: name: Perez, Whitney D.
name: Perez-Torres, Carlos J.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Radiation-induced brain injury is a common long-term side effect for brain cancer survivors, leading to a reduced quality of life. Although there is growing research pertaining to this topic, the relationship between cognitive and radiologically detected lesions of radiation-induced brain injury in humans remains unclear. Furthermore, clinically translatable similarities between rodent models and human findings are also undefined. The objective of this review is to then identify the current evidence of radiation-induced brain injury in humans and to compare these findings to current rodent models of radiation-induced brain injury. This review includes an examination of the current literature on cognitive and radiological characteristics of radiation-induced brain injury in humans and rodents. A thorough search was conducted on PubMed, Web of Science, and Scopus to identify studies that performed cognitive assessments and magnetic resonance imaging techniques on either humans or rodents after cranial radiation therapy. A qualitative synthesis of the data is herein reported. A total of 153 studies pertaining to cognitively or radiologically detected radiation injury of the brain are included in this systematic review; 106 studies provided data on humans while 47 studies provided data on rodents. Cognitive deficits in humans manifest across multiple domains after brain irradiation. Radiological evidence in humans highlight various neuroimaging-detectable changes post-irradiation. It is unclear, however, whether these findings reflect ground truth or research interests. Additionally, rodent models do not comprehensively reproduce characteristics of cognitive and radiological injury currently identified in humans. This systematic review demonstrates that associations between and within cognitive and radiological radiation-induced brain injuries often rely on the type of assessment. Well-designed studies that evaluate the spectrum of potential injury are required for a precise understanding of not only the clinical significance of radiation-induced brain injury in humans, but also how to replicate injury development in pre-clinical models.
A class of high-order Runge-Kutta-Chebyshev stability polynomials
Creators: name: O'Sullivan, Stephen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: 65L04, 65L20, 65M20

description: The analytic form of a new class of factorized Runge-Kutta-Chebyshev (FRKC) stability polynomials of arbitrary order $N$ is presented. Roots of FRKC stability polynomials of degree $L=MN$ are used to construct explicit schemes comprising $L$ forward Euler stages with internal stability ensured through a sequencing algorithm which limits the internal amplification factors to $\sim L^2$. The associated stability domain scales as $M^2$ along the real axis. Marginally stable real-valued points on the interior of the stability domain are removed via a prescribed damping procedure. By construction, FRKC schemes meet all linear order conditions; for nonlinear problems at orders above 2, complex splitting or Butcher series composition methods are required. Linear order conditions of the FRKC stability polynomials are verified at orders 2, 4, and 6 in numerical experiments. Comparative studies with existing methods show the second-order unsplit FRKC2 scheme and higher order (4 and 6) split FRKCs schemes are efficient for large moderately stiff problems.
description: 24 pages, 5 figures. Accepted for publication in Journal of Computational Physics, 22 Jul 2015. Revised
Schulbegleitung an Förderschulen weiterentwickeln. Pool-Modelle an Förderzentren mit dem Förderschwerpunkt geistige Entwicklung in Bayern
Creators: name: Dworschak, Wolfgang
name: Fitzek, Tobias
name: Lüders, Lisa Marie
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 370 Erziehung, Schul- und Bildungswesen

description: Die klassische Schulbegleitung als Einzelfallmaßnahme birgt neben Chancen auch Risiken. Begründet ist dies besonders durch die 1:1-Zuordnung. Seit der Einführung des Bundesteilhabegesetzes sind Pool-Modelle möglich, bei denen die Unterstützung an mehrere Leistungsberechtigte gemeinsam erbracht wird. Dieser Forschungsbericht stellt die Ergebnisse eines Modellprojektes vor, das von 2019-2023 Pool-Modelle der Schulbegleitung an Förderschulen mit dem sonderpädagogischen Schwerpunkt geistige Entwicklung erprobt hat. In den Blick genommen werden strukturelle und organisatorische Aspekte sowie die Rückmeldungen der Akteursgruppen als auch pädagogische und inhaltliche Fragen.
Aborto, abandono, y la muerte de Augusta García Platas en Ayacucho, Perú, 1946
Creators: name: López, Raúl Necochea
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Resumen Augusta García Platas murió tras un aborto clandestino en Ayacucho en 1946. Este ensayo, basado en materiales del Archivo Histórico de Ayacucho, da cuenta del proceso criminal que se abrió para determinar los responsables de su muerte. A pesar de que sindicaron a ciertos individuos como culpables directos de provocar el aborto, las autoridades judiciales consideraban que la causa de fondo de la muerte de la joven había sido el abandono por parte de quienes debían velar por su salud física y moral. Este caso nos brinda la oportunidad de esclarecer las estrategias que los implicados usaban para defenderse de acusaciones criminales. Además, nos ayuda a entender las diversas deficiencias del Poder Judicial peruano de mediados del siglo XX.
Sneutrino Higgs models explain lepton non-universality in CMS excesses
Creators: name: Berger, Joshua
name: Dror, Jeff Asaf
name: Ng, Wee Hao
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Recent searches for first-generation leptoquarks and heavy right-handed $W_R$ bosons have seen excesses in final states with electrons and jets. A bizarre property of these excesses is that they appear to violate lepton universality. With these results in mind, we study the phenomenology of supersymmetric models in which the Higgs arises as the sneutrino in an electron supermultiplet. Since the electron is singled out in this approach, one can naturally account for the lepton flavor structure of the excesses. In this work, we show that in such a framework, one can significantly alleviate the tension between the Standard Model and the data and yet evade current constraints from other searches. Lastly we point out that correlated excesses are expected to be seen in future multilepton searches.
description: 17 pages, 7 figures
OSSDIP: Open Source Secure Data Infrastructure and Processes Platform that Supports Data Visiting
Creators: name: Weise, Martin
name: Grantner, Tobias
name: Mahler, Lukas
name: Rauber, Andreas
Publisher: name: Zenodo
Year: 2022

description: Poster as presented at IKT Sicherheitskonferenz held at Vienna, Austria.
Discordant rapid HIV tests: lessons from a low-resource community
Creators: name: Irabor,
name: Robertson,
name: Audu,
name: Akpa,
name: Muyibi,
name: Solanke,
name: Berzins,
name: Kuti,
name: Ogunniyi,
name: Adetunji,
name: Ladipo,
name: Mosuro,
name: Adewole,
name: Imhansoloeva,
name: Taiwo,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: HIV rapid antibody tests are widely used in Africa, but dual testing sometimes produces discordant results. It is not clear if discordant rapid HIV tests should always heighten suspicion by frontline health workers that early HIV infection is present. Some studies have reported that discordant rapid tests have value for identifying early HIV infection in high HIV prevalence populations. It is not known if rapid test performance influenced this conclusion, or if this observation will hold true for low HIV prevalence populations. We therefore explored the occurrence of discordant rapid HIV tests in a low-resource community.
"ЮКСАК МАЪНАВИЯТ – ЕНГИЛМАС КУЧ" АСАРИДА РАҲБАР МАЪНАВИЯТИ, МУЛОҚОТ МАДАНИЯТИ ҲАҚИДА АЙТИЛГАН ФИКРЛАР
Creators: name: , Sherozbek
Publisher: name: Zenodo
Year: 2022
Subjects: Раҳбар, ходим, маънавият, нутқ, бошқарув.

description: Мақолада Республикамизнинг Биринчи Президенти И.А.Каримовнинг “Юксак маънавият – енгилмас куч” асарида раҳбар ва унинг маънавий қиёфаси, мулоқот маданияти қандай бўлиши кераклиги ҳақида айтилган фикрлар илмий таҳлил ва тадқиқ этилган.