cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Protective effect of hydroalcoholic extract of Passiflora caerulea aerial parts on cadmium chloride-induced renal dysfunction in male rats
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Background and Aims: Passiflora caerulea has antioxidant properties. The present study aimed to assess the effects of hydroalcoholic extract of Passiflora caerulea aerial parts on cadmium chloride-induced renal dysfunction in male rats.\nMaterials and Methods: In this experimental study, 54 adults male Wistar rats 200±10 gr were divided into 6 groups (N=9). Control group, the sham group that received 0.2 ml/kg of distilled water as solvent. Renal Injury induction group: received 2 mg/kg cadmium chloride intraperitoneally (IP) for 21 days. Treatment groups 1, 2, and 3, respectively, received 2 mg/kg cadmium chloride IP for 21 days, followed by 150, 300, and 450 mg/kg hydroalcoholic extracts of aerial parts of Passiflora caerulea intraperitoneally for 30 days. At the end, blood samples were taken from all animals. Serum levels of sodium, potassium, Blood Urea Nitrogen (BUN), creatinine and uric acid were measured. Data were analyzed using SPSS 18, ANOVA and Tukey test.\nResults: Cadmium chloride caused a significant increase in serum concentrations of creatinine (P<0.001), BUN (P<0.001), sodium (P<0.001), potassium (P=0.04) and uric acid (P<0.001) compared to the control group. Different amounts of hydroalcoholic extract of aerial parts of Passiflora caerulea could significantly reduce serum concentrations of creatinine (P<0.001), BUN (P<0.001), sodium (P<0.001), potassium (P<0.001) and uric acid (P<0.001) in all treatment groups compared to cadmium chloride.\nConclusion: As evidenced by the obtained results, the hydroalcoholic extract of aerial parts of the Passiflora caerulea plant has a protective effect on cadmium chloride-induced renal dysfunction in male rats.\n
At the root: Defining and halting progression of early chronic obstructive pulmonary disease
Creators: name: Celli, B.R.
name: Tal-Singer, R.
name: Segal, L.N.
name: Kostikas, K.
name: Paine, R.
name: Woodruff, G.P.
name: Rafii, S.
name: Graham Barr, R.
name: Crystal, R.G.
name: Martinez, F.J.
name: Fageras, M.
name: Boucher, R.C.
name: Wedzicha, J.A.
name: Groenke, L.
name: Han, M.K.
name: Shaykhiev, R.
name: Rennard, S.I.
name: Calverley, P.M.A.
name: Stevenson, C.
name: Christenson, S.A.
name: Vestbo, J.
name: Kesimer, M.
name: Allinson, J.P.
name: Hoffman, E.A.
name: Curtis, J.L.
name: Freeman, C.M.
Publisher: name: American Thoracic Society
Year: 2018

description: Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with varying presentation and progression but with a limited number of disease-modifying therapies (1). This marked heterogeneity impedes identification of subpopulations at risk for accelerated progression, thwarting therapeutic advances. Most COPD studies have included populations with mean ages older than 60 years (2). However, it is increasingly evident that lung function trajectories in COPD differ significantly and that differences are detectable in young adulthood (3–5). In this Perspective, we highlight the need to distinguish “early disease” from late “mild disease,” propose an operational definition of early COPD for use in research studies, and attempt to unify current views on potential disease mechanisms. We focus on smoking, the chief etiologic factor for COPD in the industrialized world. Whether pathogenic mechanisms and effective treatments are shared with the sizable fraction of COPD in never-smokers or resulting from biomass fuel, electronic nicotine delivery systems, and other exposures, are separate, significant questions. We argue that refocusing investigation on early COPD could revolutionize understanding and therapies of this leading cause of worldwide death.
Proceedings 6th Workshop on Formal Methods and Analysis in SPL Engineering
Creators: name: Atlee, Joanne M.
name: Gnesi, Stefania
Publisher: name: arXiv
Year: 2015
Subjects: subject: Software Engineering (cs.SE)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: The workshop aims at reviewing the state of the art and the state of the practice in which formal methods and analysis approaches are currently applied in SPLE. This leads to a discussion of a research agenda for the extension of existing formal approaches and the development of new formal techniques for dealing with the particular needs of SPLE. To achieve the above objectives, the workshop is intended as a highly interactive event fostering discussion and initiating collaborations between the participants from both communities.
title: Radiogenomics classification of the 1p/19q status in presumed low-grade gliomas
Creators: name: van der Voort, Sebastian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Molecular, genomics and proteomics
subject: Cancer
subject: Computer Applications-Detection, diagnosis
subject: MR
subject: Oncology
subject: Neuroradiology brain

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study is to develop and evaluate a method to non-invasively determine the 1p/19q co-deletion status in presumed low-grade gliomas. The 1p/19q co-deletion status, i.e. combined deletion of the short arm of chromosome 1 and the long...
Classification of bounded Baire class $ξ$ functions
Creators: name: Kiss, Viktor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: Primary 26A21, Secondary 03E15, 54H05

description: Kechris and Louveau showed that each real-valued bounded Baire class 1 function defined on a compact metric space can be written as an alternating sum of a decreasing countable transfinite sequence of upper semi-continuous functions. Moreover, the length of the shortest such sequence is essentially the same as the value of certain natural ranks they defined on the Baire class 1 functions. They also introduced the notion of pseudouniform convergence to generate some classes of bounded Baire class 1 functions from others. The main aim of this paper is to generalize their results to Baire class $ξ$ functions. For our proofs to go through, it was essential to first obtain similar results for Baire class 1 functions defined on not necessary compact Polish spaces. Using these new classifications of bounded Baire class $ξ$ functions, one can define natural ranks on these classes. We show that these ranks essentially coincide with those defined by Elekes et. al.
Additional file 9 of Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis
Creators: name: Zhang, Xiaotian
name: Wu, Yuxia
name: Zhang, Yang
name: Zhang, Jin
name: Chu, Pengfei
name: Chen, Kunci
name: Liu, Haiyang
name: Luo, Qing
name: Fei, Shuzhan
name: Zhao, Jian
name: Ou, Mi
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 9: Table S1. List of GO terms enriched from DEGs in males compared to the corresponding females at 10, 15, 20, 25, 30 dpf. Table S2. List of GO terms enriched from DEGs in males compared to the corresponding females at 60, 90, 120, 150, 180 dpf. Table S3. List of KEGG pathway enriched from DEGS in males compared with corresponding females at 10, 15, 20, 25, 30 dpf. Table S4. List of KEGG pathway enriched from DEGS in males compared with corresponding females at 60, 90, 120, 150, 180 dpf. Table S5. List of sex-related DEGs in males compared with corresponding females at 10, 15, 20, 25, 30 dpf. Table S6. List of sex-related DEGs in males compared with corresponding females at 60, 90, 120, 150, 180 dpf. Table S7. List of GO terms enriched from 165 sex-related DEGs. Table S8. List of KEGG pathways enriched from 165 sex-related DEGs. Table S9. List of GO terms enriched from the female profile DEGs. Table S10. List of KEGG pathways enriched from the female profile DEGs. Table S11. List of GO terms enriched from the male profile DEGs. Table S12. List of KEGG pathways enriched from the male profile DEGs.
The effect of physical activity on metabolic and anthropometric factors in pre and postmenopausal women
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Background and Aims: The beneficial effect of physical activity on some risk factors improves and promotes the metabolic and physiological factors in individuals. Women who have gone through menopause are at a greater risk. Therefore, the present study aimed to investigate the effect of physical activity on metabolic and anthropometric factors in pre and postmenopausal women.\nMaterials and Methods: A total of 77 women participated in this quasi-experimental study. The subjects were non-randomly divided into four groups including premenopausal women [active (n= 18), inactive (n= 17)] and postmenopausal women [active (n = 23), inactive (n = 19)] which had regular activity in the gyms of Rasht, Iran for three 90-minute sessions for at least 6 months. Bouchard Three-Day Physical Activity Record was completed by subjects to assess energy expenditure and to determine levels of physical activity. Then body mass index (BMI), waist-hip ratio (WHR), and body fat percent (BF%) of subjects were measured. Also, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and TC/HDL-C were measured. Data analysis was performed by one-way analysis of variance (ANOVA) and Tukey’s test using SPSS software (version 20).\nResults: The results of this study indicated no significant difference in SBP, DBP, BMI, BF%, and WHR between pre and postmenopausal women (active and inactive). However, significant differences (P≤0.01) were observed in TC, TG, LDL-C, HDL-C, and TC/HDL-C between pre and postmenopausal inactive and active women.\nConclusion: The results of this study revealed that although physical activity failed to affect BMI, weight, or BF%, it could desirably and significantly affect lipid profile in pre and postmenopausal women.\n
(101814) Valentine Green
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Effect of resistance training on structural injuries of skeletal muscle induced by different doses of Boldenone in male rats
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Background and Aims: The use of anabolic steroids is common among athletes who perform resistance training; nonetheless, the effect of their abuse, along with resistance training, on the structural destruction of skeletal muscles is not fully understood. The present study aimed to assess the effect of different doses of Boldenone, along with resistance training, on muscle injury.\nMaterials and Methods: In this experimental study, 36 male Wistar rats (189.53±5.94 gr) were randomly assigned to six groups (n=6 in each group): control, Boldenone (2mg/kg), Boldenone (5mg/kg), training, training+Boldenone (2mg/kg), and training+Boldenone (5mg/kg). Boldenone steroid was injected twice a week into the rat serine muscle. The resistance training program consisted of ladder-climbing 5×3, three times per week for six weeks. It began with 50% of the one-repetition maximum of rats and increased to 100% in the final week. Histopathological changes in quadriceps muscle tissue were assessed using hematoxylin staining and optical microscopic. To assess the normality of data, the Kolmogorov-Smirnov test was used. One-way analysis of variance (ANOVA) and Tukey post hoc test were employed for data analysis at a significance level of P≤0.05.\nResults: Based on the results, there was no significant difference in the weight of rats in all groups. In the groups receiving Boldenone, mild and moderate damages were observed in the tissue structure of the quadriceps muscle, which was slightly improved by performing resistance exercises; however, the difference was not statistically significant (P<0.05).\nConclusion: Resistance training in the present study did not seemingly prevent or improve the muscle injuries caused by taking Boldenone steroids.\n
(101817) Joseph Taverner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SUNNYMILKFUZZER - AN OPTIMIZED FUZZER FOR JVM-BASED LANGUAGE
Creators: name: Shao, Junyang
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Software testing, verification and validation
Software and application security
Performance evaluation

description: This thesis presents an in-depth investigation into the opportunities of optimizing the performance (throughput) of fuzzing on Java Virtual Machine (JVM)-based languages. The study identifies five main areas for potential optimization, each of which contributes to the performance bottlenecks in the existing state-of-the-art Java fuzzer, Jazzer.
 Firstly, the use of coverage probes is recognized as costly due to the native method call, including call frame generation and destruction, while it only performs a simple byte increment. Secondly, the probes may become exhausted, which subsequently cease to generate signals for new interesting inputs, while the associated costs persist. Thirdly, the scanning of the coverage map is expensive, particularly for targets with a large loaded bytecode. Given that test inputs can only execute a portion of these, the probes for most bytecodes are scanned repeatedly without generating any signals, indicating a need for a more structured coverage map design to skip the code probes effectively. Lastly, exception handling in JVM is costly as it automatically fills in the stack trace whenever an exception object is created, even when most targets don't utilize this information.
 The study then designs and implements optimization techniques for these opportunities. We believe we provide the optimal solution for the first opportunity, while better optimizations could be proposed for the second, third, and fourth. The collective improvement brought about by these implementations is on average 138% and up to 441% in throughput. This work, thus, offers valuable insights into enhancing the efficiency of fuzz testing in JVM languages and paves the way for further research in optimizing other areas of JVM-based-language fuzzing performance.
title: Gastro-entero-pancreatic Neuroendocrine Tumor: Interventional Radiology management.
Creators: name: Tipaldi, Marcello Andrea
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Catheter arteriography
subject: Percutaneous
subject: Ablation procedures
subject: Embolisation
subject: Neoplasia
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Gastro-Entero-Pancreatic Neuroendocrine tumours(GEP-NETs) are a vast and heterogeneous group of neoplasmsthat may involve organs of the foregut (oesophagus,stomach, proximal duodenum, liver, pancreas), the midgut(distal...
E-cigarette use causes a unique innate immune response in the lung, involving increased neutrophilic activation and altered mucin secretion
Creators: name: Abdelwahab, S.
name: Clapp, P.W.
name: Rebuli, M.E.
name: Haridass, P.
name: Jaspers, I.
name: Kesimer, M.
name: Reidel, B.
name: Radicioni, G.
name: Alexis, N.E.
name: Ford, A.A.
Publisher: name: American Thoracic Society
Year: 2018

description: Rationale: E-cigarettes have become increasingly popular and little is known about their potential adverse health effects. Objectives: To determine the effects of e-cigarette use on the airways. Methods: Induced sputum samples from cigarette smokers, e-cigarette users, and nonsmokers were analyzed by quantitative proteomics, and the total and individual concentrations of mucins MUC5AC and MUC5B were determined by light scattering/refractometry and labeled mass spectrometry, respectively. Neutrophil extracellular trap (NET) formation rates were also determined for the same groups. Measurements and Main Results: E-cigarette users exhibited significant increases in aldehyde-detoxification and oxidative stress-related proteins associated with cigarette smoke compared with nonsmokers. The levels of innate defense proteins associated with chronic obstructive pulmonary disease, such as elastase and matrix metalloproteinase-9, were significantly elevated in e-cigarette users as well. E-cigarette users' sputum also uniquely exhibited significant increases in neutrophil granulocyte-related and NET-related proteins, such as myeloperoxidase, azurocidin, and protein-arginine deiminase 4, despite no significant elevation in neutrophil cell counts. Peripheral neutrophils from e-cigarette users showed increased susceptibility to phorbol 12-myristate 13-acetate-induced NETosis. Finally, a compositional change in the gel-forming building blocks of airway mucus (i.e., an elevated concentration of mucin MUC5AC) was observed in both cigarette smokers and e-cigarette users. Conclusions: Together, our results indicate that e-cigarette use alters the profile of innate defense proteins in airway secretions, inducing similar and unique changes relative to cigarette smoking. These data challenge the concept that e-cigarettes are a healthier alternative to cigarettes.
title: Constitutional bone diseases...Not so difficult. (I) Osteochondrodysplasias
Creators: name: Fajardo-Cascos, Manuel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Dysplasias
subject: Education
subject: Conventional radiography
subject: Paediatric
subject: Musculoskeletal bone

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Describe the radiographic features and classification of the most frequent...
Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways
Creators: name: Kesimer, M.
name: Davis, C.W.
name: Griffith, J.D.
name: Ballard, S.T.
name: Coakley, R.D.
name: Makhov, A.M.
name: Wang, T.T.
name: Nguyen, K.
name: Evans, J.R.
name: Ford, A.A.
name: Abdullah, L.H.
Publisher: name: NLM (Medline)
Year: 2017

description: In cystic fibrosis (CF), airway mucus becomes thick and viscous, and its clearance from the airways is impaired. The gel-forming mucins undergo an ordered "unpacking/maturation" process after granular release that requires an optimum postsecretory environment, including hydration and pH. We hypothesized that this unpacking process is compromised in the CF lung due to abnormal transepithelial fluid transport that reduces airway surface hydration and alters ionic composition. Using human tracheobronchial epithelial cells derived from non-CF and CF donors and mucus samples from human subjects and domestic pigs, we investigated the process of postsecretory mucin unfolding/maturation, how these processes are defective in CF airways, and the probable mechanism underlying defective unfolding. First, we found that mucins released into a normal lung environment transform from a compact granular form to a linear form. Second, we demonstrated that this maturation process is defective in the CF airway environment. Finally, we demonstrated that independent of HCO3- and pH levels, airway surface dehydration was the major determinant of this abnormal unfolding process. This defective unfolding/maturation process after granular release suggests that the CF extracellular environment is ion/water depleted and likely contributes to abnormal mucus properties in CF airways prior to infection and inflammation.
Enhancing the stability of the synchronization of multivariable coupled oscillators
Creators: name: Sevilla-Escoboza, R.
name: Gutiérrez, R.
name: Huerta-Cuellar, G.
name: Boccaletti, S.
name: Gómez-Gardeñes, J.
name: Arenas, A.
name: Buldú, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Synchronization processes in populations of identical networked oscillators are in the focus of intense studies in physical, biological, technological and social systems. Here we analyze the stability of the synchronization of a network of oscillators coupled through different variables. Under the assumption of an equal topology of connections for all variables, the master stability function formalism allows assessing and quantifying the stability properties of the synchronization manifold when the coupling is transferred from one variable to another. We report on the existence of an optimal coupling transference that maximizes the stability of the synchronous state in a network of Rössler-like oscillators. Finally, we design an experimental implementation (using nonlinear electronic circuits) which grounds the robustness of the theoretical predictions against parameter mismatches, as well as against intrinsic noise of the system.
Prevalence of hypertension, prehypertension and related factors among Under 40 years old health, medical and administrative staffs in Birjand, 2021
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Background and Aims: Prehypertension is a warning sign in young people since it is an indicator of the risk of hypertension in adulthood. This study aimed to determine the prevalence of hypertension and prehypertension, as well as their related factors, among health, medical and administrative staff in Birjand, Iran.\nMaterials and Methods: This is a descriptive-analytical cross-sectional study carried out on 1,180 health and administrative staff under 40 years old. Data were collected through a standard World Health Organization STEP questionnaire, measuring blood pressure, as well as height and weight, by the researcher and trained interviewers. To ensure the accuracy of the measurement, the employees with hypertension and prehypertension were re-evaluated according to the JNC7 criteria two weeks later. The data were analyzed using t-test, One-Way ANOVA, Chi-square, and logistic regression in the SPSS software (version 20).\nResults: The prevalence of hypertension and prehypertension was 5.3% and 34.2%, respectively. The mean for systolic blood pressure was 114.2±11.03 mmHg. Based on logistic regression analysis, age, gender, workplace, and family history had a significant relationship with hypertension, while body mass index and socioeconomic status had a significant relationship with prehypertension (P<0.05).\nConclusion: This study showed that a significant percentage of employees at young ages had prehypertension; however, they were unaware of their disease due to a lack of screening and that they were asymptomatic. Therefore, this group should benefit from intervention programs to prevent and control high blood pressure among them. The findings also suggest that this issue should be considered more seriously in the staff of other departments, compared to the medical staff. Moreover, the findings indicated that obesity can also play a role in prehypertension.\n
title: Epidemiology and etiology of solitary cavitary pulmonary lesions: a retrospective study
Creators: name: Van Hoyweghen, Astrid
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Lung
subject: Thorax
subject: CT
subject: Diagnostic procedure
subject: Epidemiology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: A cavity is defined by the Fleischner Society Glossary of Terms for Thoracic Imaging as "a gas-filled space, seen as a lucency or low-attenuation area, within pulmonary consolidation, a mass or a nodule" [1]. It is well to remember that cavities are...
(101812) Richard Lewis Nettleship
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Measuring airway mucin 2 in patients with severe chronic obstructive pulmonary disease with bacterial colonization
Creators: name: Dickey, B.F.
name: Evans, C.M.
name: Boucher, R.C.
name: Kesimer, M.
name: Thornton, D.
name: Fahy, J.V.
Publisher: name: American Thoracic Society
Year: 2016

description: Sibila and colleagues reported an analysis of the levels of the secreted polymeric mucins MUC2, MUC5AC, and MUC5B in the sputum and bronchoalveolar lavage fluid of patients with severe chronic obstructive pulmonary disease (COPD) (1). We are writing because they found a very high level of MUC2 in both specimens, whereas most recent studies by others find little or no MUC2 in the airway. Therefore, this report raises the possibility of an error in measurement that could cause confusion in the field.
Comparison of mental development between healthy children and those with hypothyroidism in, South Khorasan, Iran-2020
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Background and Aims: Congenital hypothyroidism is the most common and preventable cause of mental retardation in children. This study aimed to investigate mental development in healthy children and children with hypothyroidism treated in South Khorasan in 2020.\nMaterials and Methods: This cross-sectional study was performed on 64 children aged five to seven years in South Khorasan, divided into two groups (n=32): the control group and the group with congenital hypothyroidism. Data were collected using checklist demographic data, including gender, age, treatment, socioeconomic status, place of residence, and parents’ level of education, as well as children’s intellectual quotient (IQ) based on the Raven’s Progressive Matrices test of intelligence. Data were analyzed using the SPSS software (version 24) at a significant level of less than 0.05\nResults: The mean age of children was 6.22±0.79 years, and there was no significant difference between the two groups concerning their age (P=0.78). The results also showed no significant difference between the groups for their gender (P>0.05). The average IQ score was 125.50±8.00 in the population with hypothyroidism and 127.14±5.41 in healthy children; however, the difference was not statistically significant (P=0.50). Additionally, there was no significant relationship between the IQ scores and case groups (P=0.40). Finally, the comparison of IQ classes was not significant between the two groups regarding their age (P>0.05) and gender (P>0.05).\nConclusion: The results of the present study showed that the screening program for congenital hypothyroidism can positively affect children’s mental development or IQ.\n
The NAD +-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
Creators: name: Tolun, G.
name: Lu, J.
name: Griffith, J.D.
name: Li, X.
name: Xu, Q.
name: Zheng, X.
name: Guo, X.
name: Sheehan, J.K.
name: Kesimer, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: SIRT1, a NAD +-dependent protein deacetylase, is an important regulator in cellular stress response and energy metabolism. While the list of SIRT1 substrates is growing, how the activity of SIRT1 is regulated remains unclear. We have previously reported that SIRT1 is activated by phosphorylation at a conserved Thr 522 residue in response to environmental stress. Here we demonstrate that phosphorylation of Thr 522 activates SIRT1 through modulation of its oligomeric status. We provide evidence that nonphosphorylated SIRT1 protein is aggregation-prone in vitro and in cultured cells. Conversely, phosphorylated SIRT1 protein is largely in the monomeric state and more active. Our findings reveal a novel mechanism for environmental regulation of SIRT1 activity, which may have important implications in understanding the molecular mechanism of stress response, cell survival, and aging.
MEMORABILIA MODERNISTA DA CASA JK: a lembrança e a fruição estética no universo dos objetos
Creators: name: Caixeta de Sousa, João Francisco
Publisher: name: Zenodo
Year: 2023
Subjects: memorabilia
Kubitschek
Residence Museum
Modernism
memory

description: Esta pesquisa tem como objetivo fortalecer o conceito de memorabilia, identificando suas tipologias e formatos de exposição, além de explorar sua evolução ao longo do tempo e suas configurações contemporâneas. O Museu Casa Kubitschek, localizado na região da Pampulha, em Belo Horizonte, Minas Gerais, será utilizado como base da investigação. A pesquisa tem como propósito compreender o mundo dos objetos e suas possibilidades nas artes, explorando a capacidade de despertar os sentidos e evocar memórias e percepções por intermédio dos elementos compositivos presentes em sua materialidade. Além disso, busca-se entender as ações sistêmicas e recorrentes em espaços culturais que se utilizam da memorabilia como estratégia expositiva. A investigação também abrangerá o movimento modernista e sua influência nas artes, arquitetura e design, tanto em nível global como no Brasil. Serão analisados desde os trabalhos dos pioneiros até a construção do Projeto Modernista da Pampulha e, posteriormente, Brasília. Neste contexto, será investigado o design brasileiro e sua importância no acervo do Museu Casa Kubitschek. Para alcançar esses objetivos, os procedimentos metodológicos incluirão investigação bibliográfica, práticas curatoriais, colecionismo e narrativas que possibilitam a fruição estética. A pesquisa é estruturada, portanto, a partir de conceitos e da coleção de objetos nos espaços das artes, das memórias e, mais especificamente, nos museus. ABSTRACT This research aims to strengthen the concept of memorabilia by identifying its typologies and exhibition formats, as well as exploring its evolution over time and contemporary configurations. The Casa Kubitschek Museum, located in the Pampulha region of Belo Horizonte, Minas Gerais, will serve as the basis for the investigation. The research aims to understand the world of objects and their possibilities in the arts, exploring their ability to arouse senses and evoke memories and perceptions through the compositional elements present in their materiality. Additionally, the investigation seeks to understand the recurring systemic actions in cultural spaces that use memorabilia as an exhibition strategy. The research will also cover the modernist movement and its influence on arts, architecture, and design, both globally and in Brazil. From the works of pioneers to the construction of the Modernist Project in Pampulha and later Brasília, the Brazilian design and its importance in the Casa Kubitschek Museum's collection will also be investigated. To achieve these objectives, the methodological procedures will include bibliographic research, curatorial practices, collecting, and narratives that allow for aesthetic enjoyment. The research is structured based on concepts and the collection of objects in the spaces of arts, memories, and, more specifically, museums.
Possible vertical transmission of COVID-19 from mother to the newborn;  a case report
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Vertical transmission of the 2019 novel coronavirus (COVID-19) has been reported in several case reports and case series, while the data regarding its transmission is controversial. Therefore, presenting different experiences from different regions can shed light on the virus's behavior during pregnancy. We reported a possible vertical transmission of COVID-19 from a mother to the neonate. A pregnant woman with signs and symptoms of mild respiratory illness and a low fetal heart rate at 36 weeks of gestation was induced to terminate the pregnancy. She had a positive COVID-19 test using RT-PCR before admission to the hospital, underwent an emergency cesarean section, and gave birth to a girl neonate. The COVID-19 test for the neonate was also positive. Although vertical transmission of COVID-19 has not been confirmed yet, there is growing evidence. Careful attention to the mother and newborn with positive COVID-19 and long-term follow-ups are needed to better understand the virus’s behavior during pregnancy.
title: Osteosclerosis – The list of possibilities
Creators: name: Gaio, Raquel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Conventional radiography
subject: CT
subject: Diagnostic procedure
subject: Metabolic disorders
subject: Dysplasias

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this paper is to discuss and illustrate some of the most common diseases that cause diffuse osteosclerosis, emphasizing the features that may help the viewer with the differential...
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Creators: name: Gerszten, R.E.
name: Ampleford, E.
name: Jacobson, S.
name: Cornell, E.
name: Masters, B.
name: Tracy, R.P.
name: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
name: Basta, P.
name: Miller, M.
name: Herrera, J.
name: Pratte, K.A.
name: Liu, Y.
name: Bowler, R.P.
name: Comellas, A.P.
name: Raffield, L.M.
name: Auer, P.
name: Hastie, A.T.
name: Dang, H.
name: Rich, S.S.
name: Barjaktarevic, I.
name: Gillenwater, L.A.
name: Ortega, V.E.
name: O'Neal, W.K.
name: Freeman, C.M.
name: Ngo, D.
name: Emson, C.
name: Taylor, K.D.
name: Johnson, W.C.
name: Rotter, J.I.
name: Clish, C.B.
name: Labaki, W.W.
name: Hawkins, G.A.
name: Durda, P.
name: Curtis, J.L.
name: Peters, S.
name: Doerschuk, C.
name: Reiner, A.P.
name: Guo, X.
name: Papanicolaou, G.
Publisher: name: Wiley-VCH Verlag
Year: 2020

description: Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively and are rapidly growing in popularity. However, comparisons to conventional immunoassays remain underexplored, leaving investigators unsure when cross-assay comparisons are appropriate. The correlation of results from immunoassays with relative protein quantification is explored by SOMAscan. For 63 proteins assessed in two chronic obstructive pulmonary disease (COPD) cohorts, subpopulations and intermediate outcome measures in COPD Study (SPIROMICS), and COPDGene, using myriad rules based medicine multiplex immunoassays and SOMAscan, Spearman correlation coefficients range from −0.13 to 0.97, with a median correlation coefficient of ≈0.5 and consistent results across cohorts. A similar range is observed for immunoassays in the population-based Multi-Ethnic Study of Atherosclerosis and for other assays in COPDGene and SPIROMICS. Comparisons of relative quantification from the antibody-based Olink platform and SOMAscan in a small cohort of myocardial infarction patients also show a wide correlation range. Finally, cis pQTL data, mass spectrometry aptamer confirmation, and other publicly available data are integrated to assess relationships with observed correlations. Correlation between proteomics assays shows a wide range and should be carefully considered when comparing and meta-analyzing proteomics data across assays and studies.
An evaluation of the performance of autoclave devices in the sterilization process using biological method in dental clinics of Birjand in 2019
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Today, due to the high prevalence of infectious diseases and the risk of infection transmission in dental clinics, the control of infectious agents is critically important in dentistry. Given the importance of proper autoclave performance in dental processes, the aim of this study was to evaluate the performance of autoclave devices in the sterilization process using biological methods in dental clinics in Birjand. In this analytical cross-sectional study, all 65 dental clinics in Birjand were included. After collecting the questionnaire about equipment sterilization process and the characteristics of the autoclave, a vial containing spores of Geobacillus stearothermophilus was used for biological monitoring of autoclave devices. At the end of the autoclave cycle, the biological vials were incubated for 24-48 hours at 55 °C. Data were analyzed using Chi-Square or Fisher exact tests in SPSS 18 software. Among 46 clinics (71%) participating in this study, 36 clinics (83.7%) used class B autoclave. Out of 34 (77.3%) clinics that monitored the performance of the autoclave, 24 clinics (70.5%) used the chemical method, 6 clinics (17.5%) used the physical method and 4 clinics (12%) used biological methods. In the biological monitoring of the autoclave sterilization process in this study, the performance of one autoclave (2.2%) was reported to be inappropriate and this had a significant relationship with the number of autoclave uses. Despite the fact that biological monitoring of autoclave performance was not carried out in many dental clinics in Birjand, the results of this study showed that the autoclaves of a large number of dental clinics had good performance in the sterilization process. Given the importance of validating autoclave performance in dental processes, the quality control of autoclave devices in dental clinics can be taken into consideration.
(101815) John Henry Bakewell Green
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS
Creators: name: Couper, D.J.
name: Xing, D.
name: Bhatt, S.P.
name: Labaki, W.W.
name: Han, M.L.K.
name: Blalock, J.E.
name: Wells, J.M.
name: SPIROMICS Investigators
name: Schlange, T.
name: Freeman, C.M.
name: Wu, Y.
name: Hoffman, E.A.
name: Putcha, N.
name: Dransfield, M.T.
name: Viera, L.
name: O'Neal, W.
name: Barjaktarevic, I.
name: Gaggar, A.
name: Burkes, R.M.
name: Curtis, J.L.
Publisher: name: NLM (Medline)
Year: 2019

description: BACKGROUND: Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD. METHODS: Sputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment. AcPGP was isolated using solid phase extraction and measured by mass spectrometry. Demographics, spirometry, quality of life questionnaires, and quantitative computed tomography (CT) imaging with parametric response mapping (PRM) were obtained at baseline. Severe COPD exacerbations were recorded at 1-year of prospective follow-up. We used linear and logistic regression models to measure associations between AcPGP and features of COPD, and Kaplan-Meier analyses to measure time-to-first severe exacerbation. RESULTS: The 182 COPD participants in the analysis were 66 ± 8 years old, 62% male, 84% White race, and 39% were current smokers. AcPGP concentrations were 0.61 ± 1.89 ng/mL (mean ± SD) in sputum and 0.60 ± 1.13 ng/mL in plasma. In adjusted linear regression models, sputum AcPGP was associated with FEV1/FVC, spirometric GOLD stage, PRM-small airways disease, and PRM-emphysema. Sputum AcPGP also correlated with severe AECOPD, and elevated sputum AcPGP was associated with shorter time-to-first severe COPD exacerbation. In contrast, plasma AcPGP was not associated with symptoms, pulmonary function, or severe exacerbation risk. CONCLUSIONS: In COPD, sputum but not plasma AcPGP concentrations are associated with the severity of airflow limitation, small airways disease, emphysema, and risk for severe AECOPD at 1-year of follow-up. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01969344 (SPIROMICS).
SERMs as Contraceptives Systematic Scoping Review
Creators: name: Jindal, Jessy
name: Dixon, Sharon
name: Curtis, Chloe
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medical Specialties
subject: Obstetrics and Gynecology
subject: Medicine and Health Sciences
subject: Reproductive health
subject: SERM
subject: contraception
subject: contraceptives
subject: Sexual health

description: Selective estrogen receptor modulators (SERMs) are a class of drugs with differential, tissue-specific effects on oestrogen receptors. SERMs were originally studied as possible contraceptives, but early compounds were not found to prevent pregnancy and thus repurposed. However, new SERMs have shown potential to be highly effective contraceptives, with drugs already licensed in India and China. Due to highly heterogeneous receptor profiles in this class of drugs, SERMs could be without the same risks, side effects and contra-indications as traditional hormonal contraception because of their differential effect on estrogen receptors around the body. However, this could also mean there are different side effects and risks to consider. Little research is available compiling the evidence on SERMs as contraceptives - highlighting a gap this scoping review is trying to map.
Electrodiagnostic evaluation of cervical root involvement among patients presenting with radicular pain
Publisher: name: Birjand University of Medical Sciences
Year: 2022

description: Cervical spine pain is one of the most common problems of the spine and upper limbs, which can be axial or radicular. The present study aimed to electrodiagnostically evaluate cervical root involvement among patients presenting with radicular pain.  The population was selected using simple random sampling from patients complaining of cervical radicular pain and unilateral or bilateral upper extremity that met the inclusion criteria. Out of 120 patients studied, 21 patients (17.5%) had cervical nerve root involvement, of which 14 were women (13.7% of patients) and 7 were men (38.8% of patients). The highest and lowest prevalence was related to C7 (37.1%) and C8 and T1 cervical roots (11.4% and 4.2), respectively. Four patients (19%) had only left cervical root involvement and 3 patients (14.2%) had right cervical root involvement and 14 patients (66.6% of patients) had bilateral cervical root involvement.\nThe most common neurological finding associated with CTS cervical radiculopathy was about 52%. Based on the findings, most patients complaining of cervical radicular pain and upper extremity to investigate cervical root involvement often have no cervical radiculopathy and may have neurological causes such as carpal tunnel syndrome or musculoskeletal causes such as myofascial pain. Radicular pain and some other causes of these disorders can be simultaneously observed, which emphasizes the proper and timely use of electrodiagnostic tests and accurate examinations to diagnose nerve root damage.\n
title: The role of advanced MRI techniques to differentiate glioblastoma pseudo-progression and tumor-progression during immunotherapy.
Creators: name: Gioppo, Andrea
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Tissue characterisation
subject: Treatment effects
subject: MR-Spectroscopy
subject: MR-Diffusion/Perfusion
subject: Oncology
subject: Neuroradiology brain
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this review is to outline the current research into MRI assessment for patients undergoing...
(101806) Henry Strachey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.