cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantifying Climate Shifts Across Chilean Landscapes from the Andes to the Pacific and Atacama to Patagonia
Creators: name: Laffer, Hannah
Publisher: name: Brandeis University
Year: 2024

description: Climate change is impacting every part of our planet, from mountains to deserts to coastal areas to the tundra and beyond. Chile is an interesting country to use as a lens for examining climate change due to its vast latitudinal and altitudinal expansiveness. Existing literature about Chile’s climate is regionally focused on specific variables, aiming to answer specific questions making it difficult to piece together a more comprehensive understanding of the state of Chile’s climate. This study examines 48 years of temperature, precipitation, sea surface temperature, and wind data from 24 stations in Chile to better understand how and why Chile’s climate has changed on a broader scale. Using the Mann-Kendall test, trends were identified dictating the extent to which Chile’s climate has changed. Major findings include deviations from typical, global patterns. Annual temperatures were found to increase moving toward the equator, contrary to the idea that Earth’s poles are warming more rapidly. Analysis shows sea surface temperatures overwhelmingly decreased, while the majority of global findings indicate extreme levels of warming. Additionally, precipitation has decreased to a greater extent in areas with more precipitation than areas with drier climates, defying the paradigm that dry areas are becoming increasingly drier. Together, results from this study add to a growing body of literature about climate change in Chile and can be used to inform existing climate adaptation strategies and shed light on areas for improvement.
Theoretical Modeling of Noble Metal Nanoclusters Using Semiempirical Quantum Mechanical Methods
Creators: name: Sun, Qiwei
Publisher: name: Brandeis University
Year: 2024
Subjects: DFT
INDO
Nanocluster
Plasmon
PM7
Semiempirical method
Physical Chemistry

description: Noble metal nanoclusters are widely used in chemistry, nanotechnology, and biomedicine.However, the utility of silver (Ag) or gold (Au) nanoclusters for these applications is limited by
description: the lack of understanding of their fundamental properties. Quantum mechanical modeling has
description: been proven effective as a complement to experiments to provide insights into the metal
description: nanoclusters on the atomic scale. Semiempirical quantum mechanical methods (SEQMs) are
description: widely used in computational chemistry due to their low computational cost. The parametrization
description: of semiempirical methods was necessary due to insufficient experimental reference data on Ag
description: and Au nanoclusters at the time of development. In this dissertation, I parametrized PM7 (a
description: neglect of diatomic differential overlap method) for Ag and Au, specifically on obtaining
description: parameters that recreate the ground-state potential energy surfaces (PESs) of bare Ag and Au
description: clusters as well as thiol-protected Ag (AgSH) clusters. The resulting new parameters show
description: significant improvement relative to the default PM7 parameters for the binding energies, energy
description: changes upon displacement, and relative energies of isomers of these clusters. I also employed
description: the existing INDO/S Ag parameters to study charge transfer plasmons in Ag nanocluster dimers.
description: I have successfully shown that INDO/S is capable of quantifying the charge transfer characters in
description: the Ag dimer systems, which was not attainable previously by Time-dependent density
description: functional theory (TDDFT).
Investigation of surgical patient scheduling at the University of Ottawa Heart Institute.
Creators: name: Belisario, Ella.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Health Sciences, Health Care Management.

description: This thesis presents an attempt to assess how prediction about patients' expected stay in the operating room, intensive care and postoperative surgical units could be used in the process of scheduling of patients for cardiac surgery. The study was carried out in the setting of the University of Ottawa Heart Institute (OHI) where current scheduling practices and the process of flow of patients through surgery were studied. Data were collected from all patients who underwent cardiac surgery at the University of Ottawa Heart Institute during the 1994 and 1995 calendar years. Information of interest is the relation of demographic, clinical and procedural factors for each patient to the time of operation, length of stay in the intensive care unit after surgery, length of postoperative stay until discharge from the hospital and in-hospital mortality after surgery. As a result of the analysis of the University of Ottawa Heart Institute surgical scheduling system and patient data we (i) understood how the current system is operating, (ii) developed and assessed models for predicting length of stay in ICU after cardiac surgery. (Abstract shortened by UMI.)
Change Agents: Amee Meredith and Caterina Politi on reforming ‘one-punch’ laws
Creators: name: Dodd, Andrew
name: Wilson, Samuel
name: Jarvis, Heather
Publisher: name: Swinburne
Year: 2024

description: The death of Melbourne heart surgeon Patrick Pritzwald-Stegmann has again focused attention on the fatal consequences of so-called “one-punch” attacks.
In response to this form of violence, Australian states and territories have enacted quite different laws, often following campaigns by family members seeking justice for a lost loved one.
On this episode of Change Agents, Andrew Dodd speaks to two of these campaigners. In Victoria, Caterina Politi campaigned successfully for ten-year mandatory minimum sentences following the death of her son, David Cassai. And in the Northern Territory, Amee Meredith lobbied for tougher sentences after the death of her husband, Brett, who was also a territory police officer.
A functional programming language for quantum computation with classical control
Creators: name: Valiron, Benoit
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Mathematics.
subject: Computer Science.

description: The objective of this thesis is to develop a functional programming language for quantum computers based on the QRAM model, following the work of P. Selinger (2004) on quantum flow-charts. We construct a lambda-calculus without side-effects to deal with quantum bits. We equip this calculus with a probabilistic call-by-value operational semantics. Since quantum information cannot be duplicated due to the no-cloning property, we need a resource-sensitive type system. We develop it based on affine intuitionistic linear logic. Unlike the quantum lambda-calculus proposed by Van Tonder (2003, 2004), the resulting lambda-calculus has only one lambda-abstraction, linear and non-linear abstractions being encoded in the type system. We also integrate classical and quantum data types within our language. The main results of this work are the subject-reduction of the language and the construction of a type inference algorithm.
BIOLOGICAL RISK FACTORS FOR SPONTANEOUS MISCARRIAGE
Creators: name: Bekbauliyeva, G.N.
name: Eshmuradova, S.Sh.
Publisher: name: Zenodo
Year: 2025

description: The study included 266 women who were divided into 2 groups: 166        women with early miscarriage (I - group) and 100 women who did not experience miscarriage (II - control group)
Phytochemical variation in Canadian Hydrastis canadensis L (goldenseal) and the in vitro inhibition of human cytochrome P450-mediated drug metabolism by H canadensis and other botanicals
Creators: name: Leduc, Renee Irene
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biology, Botany.
subject: Agriculture, Plant Culture.

description: To promote recovery and crop potential of Hydrastis canadensis---a botanical threatened in Canada---wild populations were phytochemically surveyed. Berberine, hydrastine and canadine were characterized in root-rhizome, stem-leaf, and berry pulp. Comparisons with cultivated material showed no difference in alkaloid content, thus the medicinal value of cultivated material is not likely increased with addition of wild plants. Quantitative analyses suggested genetic diversity among wild populations. Regression analyses indicated a minor relationship between latitude and alkaloid yield. Because H. canadensis and other botanicals may cause adverse botanical-drug interactions, 22 botanicals were assayed for cytochrome P450 (CYP) 2C19, CYP3A4 and CYP19 inhibition. Eight botanicals inhibited CYP2C19 by ≥ 57%, 17 inhibited CYP3A4 by ≥ 40% and CYP19 by ≥ 50%, of which Arctostaphylos uva-ursi, H canadensis, Oenothera biennis, Rhodiola rosea and Sanguinaria canadensis were most potent. Regression analyses indicated berberine concentration was a significant factor in CYP3A4 and CYP19 inhibition.
Opto-electrical properties of indium gallium arsenic phosphide quaternary epilayers and multiple quantum wells lattice matched to indium phosphide.
Creators: name: Demerdjiev, Penka.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Physics, Condensed Matter.

description: $In\sb{1-{\rm x}}Ga\sb{\rm x}As\sb{\rm y}P\sb{1-{\rm y}}$ epilayers lattice matched to InP and $In\sb{1-{\rm x}}Ga\sb{\rm x}As\sb{\rm y}P\sb{1-{\rm y}}/InP$ Multiple Quantum Wells (MQWs) grown by Chemical-Beam Epitaxy (CBE) are being studied systematically using the Photovoltaic (PV) effect. At first, the Schottky barriers on the interfaces (metal-semiconductor, metal-insulator-semiconductor) are determined as an important factor for the electrical and optical properties of the samples. Samples with identical Schottky contact deposition but with an insulating layer on the front surface, have shown much smaller leakage current and yield enhanced barrier heights. The photovoltaic signal in the temperature interval 4-300K has maximum amplitude at about 150-180K for the MQW samples and at about 190K for the epilayer. An applied electric field changes the integrated intensity and spectrally shifts the allowed and forbidden transitions observed in bias dependent PV spectra of various InGaAsP/InP MQWs. The combined effect of two external factors, the thermal ionization and the electric field on the shape and magnitude of the 11H exciton peak, are discussed in terms of exciton binding energy and field ionization. The optically induced changes and energy shifting of the 11H/ exciton peak are observed, when excitation dependent double beam experiments are conducted on the $In\sb{0.72}Ga\sb{0.28}As\sb{0.68}P\sb{0.32}/InP$ MQWs. The photomodulation of the internal fields through carrier transport results in observing effective nonlinearities at milliwatt power levels. The experimentally measured transition energies for the MQWs show good agreement with the envelope wave function calculations. The observed Schottky barrier heights and band gap energies are consistent with the interpolation scheme estimations. (Abstract shortened by UMI.)
title: Trauma-related mental health problems among national humanitarian staff
title: a systematic review of the literature
titleType: Subtitle
Creators: name: Strohmeier, Hannah
name: Scholte, Willem F.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Mental illness
subject: posttraumatic stress disorder
subject: PTSD
subject: depression
subject: anxiety disorder
subject: substance use disorder
subject: suicide
subject: relief workers
subject: aid workers
subject: humanitarian organization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Working in humanitarian crisis situations is dangerous. National humanitarian staff in particular face the risk of primary and secondary trauma exposure which can lead to mental health problems. Despite this, research on the mental health of national staff is scarce, and a systematic analysis of up-to-date findings has not been undertaken yet. Objective: This article reviews the available literature on trauma-related mental health problems among national humanitarian staff. It focuses on the prevalence of selected mental health problems in relation to reference groups; sex and/or gender as predictive factors of mental health problems; and the influence of organization types on mental health problems. Method: Three databases were systematically searched for relevant studies published in the English language in peer-reviewed journals. Results: Fourteen articles matched the inclusion criteria. Findings suggest that national staff experience mental health problems and the prevalence of posttraumatic stress disorder, depression, and anxiety among this occupation group is mostly similar to or higher than among reference groups. Research on both substance use disorder and suicidal behavior among national staff is particularly scarce. The relation between sex and/or gender and mental health problems among national staff appears to be complex, and organizational staff support seems to be an important determinant for mental health. Conclusion: All findings call for increased attention from the humanitarian community and further research on the topic.
Pattern formation in geochemical systems.
Creators: name: Katsev, Sergei.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Geophysics.

description: Compositional patterns are extremely common in natural minerals. While, in many cases, variations in the solid mineral composition reflect the external changes in the environment at the time of the mineral formation, the role of self-organization is increasingly acknowledged. For example, in reaction-transport systems, the patterns may form spontaneously from an unpatterned state at the time of crystal growth and then become preserved by being "frozen" in the solid mineral. In this work, the pattern formation by self-organization is investigated by means of model construction and computer simulations in several minerals from different geologic environments. The impact of environmental noise is investigated on a model of oscillatory zoning in plagioclase feldspar. It is shown that environmental noise can lead to pattern formation such as oscillatory zoning, even when no deterministic periodic solutions exist. Coherence resonance close to the Hopf bifurcation is observed. Oscillatory zoning in barite-celestite system is simulated to quantitatively describe the results of the previously reported nucleation and growth experiments. The zoning is thought to be formed by autocatalytic growth from an aqueous solution. In addition to the description of the reaction-diffusion system in terns of partial and ordinary differential equations, a cellular automata model is proposed for the first time for this oscillatory crystallization type of problems. A quantitative model of banding in Mississippi Valley-type sphalerite is presented. Banded ring-like patterns are shown to arise due to a self-propagating sequence of growth and dissolution (coarsening wave). A two-dimensional model is presented for the first time and the conditions for the pattern generation and preservation are discussed. A number of time series analysis techniques are applied to characterize the compositional patterns observed in natural minerals as well as in the colored rythmites found in the marine clay sediments of the Ottawa Valley. Several caveats in interpreting the results of such analyses are outlined.
Production and price trends in Washington's organic farm sector in a period of rapid change.
Creators: name: Granatstein, David
name: BRADY, MICHAEL P
name: Kirby, Elizabeth
Publisher: name: Washington State University
Year: 2014
Subjects: organic farming
yield
Economics

description: The organic farm sector in Washington State experienced rapid growth from 2005-2009. Acres and number of farms have declined since, while farmgate sales reached new yearly highs in 2010-2013. Specialty crops appear to make up at least 70% of the $355 million in farmgate sales (2012). Market average organic yields were generally below NASS yields for the state, but higher prices often offset lower yields and led to greater gross revenue per acre. A number of organic growers are achieving yields ≥ the NASS averages, with higher yields correlated with larger farm size for some crops. In analyzing entry and exit trends of certified organic farms, scale, region, crop choice, and market (direct vs. wholesale) were important determinants of success. Entry rates were strongly positively correlated with total organic acres and varied widely, while exit rates were very stable over time whether in a period of expansion (2005-2009) or of decline (2009-2013).
Reclaiming the Native Mother: Native American Traditionalism and the Politics of Reproduction, 1960- 1980
Creators: name: White, Ewa Maria Magdalena
Publisher: name: Brandeis University
Year: 2024
Subjects: Feminism
Indigenous traditionalism
Native American women
Reproductive politics
Native American studies
Sterilization

description: The histories of the feminist and reproductive rights movements of the 1970s have traditionally been written within a framework that support women’s issues like abortion rights and gender equality as the forefront of the movements. Feminist activists sought progressive change through challenging the traditional gender roles of mother and wife as patriarchal obstacles which they tried to dissolve. However, the research on feminism and reproductive rights has been written primarily about white women with a focus on their struggles and goals; their voices have become associated with all women, regardless of race or ethnic background. Native American women are barely recognized in histories of feminism the 1970’s, and when they are, they are often identified as an extension of minority women who presumably desire the same changes as all other women. This essay provides an Indigenous feminist critique of how the histories of the feminist and reproductive rights movement have been applied to Native American histories. I argue that unlike white feminist activists, Native American women voiced the potential in a return to traditional gender roles as a way to strengthen their sense of identity and reconnect with their culture. I analyze the existing rhetoric about indigenous traditionalist feminism and pursue the notion that persisting settler colonialist assumptions have defined the way we think and write about indigenous feminism, traditionalism, and the effects of medical sterilization; the history of Native American sterilizations, I believe, has been too often written under the circumstances of settler influence. To address these issues, I begin with a short history of the matrilineal practices of the Navajo tribe, the role of creation stories in defining gender roles and address the “taboo mentality” of menstrual and fertility rites that has often framed settler perspectives on Native women in American history. Finally, I address the American Indian Movement and its feminist branch in their discussions of traditionalism, culminating my argument with an analysis of the sterilization epidemic of Native women that occurred in the 1970s from a consideration of the ramifications of reproduction and indigenous gender politics.
A Search for New Physics in the Dilepton Channel with the ATLAS Detector at the LHC
Creators: name: Fitzgerald, Eric
Publisher: name: Brandeis University
Year: 2014
Subjects: Physics
High Energy Physics
Particle Physics
Experimental Physics

description: This thesis presents a search for a new, neutral heavy gauge boson decaying to lepton pairs using data from the ATLAS detector at the LHC. This search is performed in two channels, using both electron-pair and muon-pair final states. The results use the full 2012 ATLAS data set from proton-proton collisions at a center-of-mass energy of sqrt(s)=8 TeV with an integrated luminosity of 21 inverse femtobarns. No statistically significant signal is found, and limits are placed on a variety of Z' models. \r A Sequential Standard Model Z', with identical couplings to fermions as the Standard Model Z0 boson, is excluded at the 95% confidence level for masses lower than 2.79 TeV in the electron channel, 2.53 TeV in the muon channels, and 2.90 TeV with the channels combined. Limits are placed on additional Z' models based on the grand unification group E6, with lower masses ranging from 2.43 to 2.58 TeV.
Using the framework of corporate culture in "mergers" to support the development of a cultural basis for integrative medicine - guidance for building an integrative medicine department or service
Creators: name: Witt, Claudia M.
name: Pérard, Marion
name: Berman, Brian
name: Berman, Susan
name: Birdsall, Timothy C.
name: Defren, Horst
name: Kümmel, Sherko
name: Deng, Gary
name: Dobos, Gustav
name: Drexler, Atje
name: Holmberg, Christine
name: Horneber, Markus
name: Jütte, Robert
name: Knutson, Lori
name: Kummer, Christopher
name: Volpers, Susanne
name: Schweiger, David
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: An increasing number of clinics offer complementary or integrative medicine services; however, clear guidance about how complementary medicine could be successfully and efficiently integrated into conventional health care settings is still lacking. Combining conventional and complementary medicine into integrative medicine can be regarded as a kind of merger. In a merger, two or more organizations - usually companies - are combined into one in order to strengthen the companies financially and strategically. The corporate culture of both merger partners has an important influence on the integration. Purpose: The aim of this project was to transfer the concept of corporate culture in mergers to the merging of two medical systems. Methods: A two-step approach (literature analyses and expert consensus procedure) was used to develop practical guidance for the development of a cultural basis for integrative medicine, based on the framework of corporate culture in “mergers,” which could be used to build an integrative medicine department or integrative medicine service. Results: Results include recommendations for general strategic dimensions (definition of the medical model, motivation for integration, clarification of the available resources, development of the integration team, and development of a communication strategy), and recommendations to overcome cultural differences (the clinic environment, the professional language, the professional image, and the implementation of evidence-based medicine). Conclusion: The framework of mergers in corporate culture provides an understanding of the difficulties involved in integrative medicine projects. The specific recommendations provide a good basis for more efficient implementation.
title: Notes floristiques vaudoises 2022
title: Notes floristiques vaudoises 2022
titleType: AlternativeTitle
Creators: name: Guénat, Jérémie
name: Hoffer-Massard, Françoise
Publisher: name: Unknown
Year: 2023

description: Cette nouvelle série de notes floristiques permet de mettre en valeur le travail de nombreux botanistes de terrain. A partir du bulletin n° 34 (Ciardo & Jutzeler 2005), année après année, sauf en 2020, la présentation d’espèces remarquables observées dans le canton de Vaud est devenue une tradition. L’inventaire lié à l’Atlas de la flore vaudoise (Cercle vaudois de botanique 2023), terminé théoriquement en décembre 2021, a permis beaucoup de découvertes et redécouvertes. Certaines observations antérieures à 2022, ou déjà mentionnées dans l’Atlas de la flore vaudoise, sont présentées dans cet article parce que nous avons estimé qu’elles méritaient d’être mises en valeur.
Temporal Information Processing Across the Senses: A Study of Visual, Vibrotactile, and Bimodal Rate Discrimination
Creators: name: Villalonga, Mercedes
Publisher: name: Brandeis University
Year: 2019
Subjects: temporal processing
multisensory stimulation
rate discrimination
visual stimulation
vibrotactile stimulation

description: Beats are among the basic units of perceptual experience. Produced by regular, intermittent stimulation, beats are most commonly associated with audition, but a similar experience can be produced by stimulation in other sensory modalities as well. In this study, I conducted two experiments to investigate beat perception in visual and vibrotactile modalities. In both experiments, subjects attempted to discriminate between pulse sequences delivered in the 3-6 Hz range, categorizing pulse sequences as either “fast” or “slow”. In the first experiment, visual, vibrotactile, and bimodal pulses were used. In the second experiment, I focused on the two unimodal conditions. On the majority of trials presented in each experiment, inter-pulse intervals (IPIs) were stochastic, perturbed by random samples from zero-mean Gaussian distributions with different variances. These perturbations produced directional changes in the IPIs, which either increased or decreased the likelihood of confusing “fast” and “slow” pulse rates. This paradigm made it possible to gauge how subjects’ judgments were influenced by successive IPIs. Logistic regression revealed strong primacy effects: in both experiments, subjects’ decisions were disproportionately influenced by each trial’s initial IPIs. Error analysis suggested consistent reliance on statistically optimal decision criteria, adjusted in real time depending on the amount of external noise present in successive IPIs. Finally, temporal information delivered by vibrotactile signals proved just as robust as that conveyed by visual signals, confirming vibrotactile stimulation’s potential for timely communication.
The role of the Set7 Lysine Methyltransferase in the development of diabetic complications
Creators: name: Rodriguez Colombo, Hanah V.
Publisher: name: Swinburne
Year: 2024

description: This thesis describes the role of Set7, an enzyme involved in gene activation, during the development of diabetic cardiovascular and renal disease. By using diverse experimental approaches, including animal models of diabetes, Set7 was identified as a mediator of early pathological changes observed in the vasculature and kidney in diabetes. The results presented here suggest that this enzyme could serve as a therapeutic target to attenuate the burden of diabetic complications.
Pressure-induced structural modifications in dioxides of group IVB elements: Titanium dioxide, zirconium dioxide and hafnium dioxide.
Creators: name: Lagarec, Ken.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Physics, Condensed Matter.

description: Four specific studies are presented in this thesis, regarding the high-pressure phases of the three compounds. ZrO$\sb2$ was studied at pressures of up to 73 GPa using energy dispersive X-ray (EDX) diffraction techniques. The quenched phase was analysed using angle dispersive X-ray (ADX) diffraction with imaging plates, and was identified as having a cotunnite-type structure (space group Pnma) by Rietveld refinement. HfO$\sb2$ was also studied to 72 GPa using EDX diffraction measurements, and its quenched phase was also identified as having a cotunnite-type structure, based on the simularities of its EDX and Raman spectra with those of the quenched phase of ZrO$\sb2$. TiO$\sb2$ was involved in two separate studies. The first is a Raman spectroscopic study up to 73 GPa, starting with anatase. Some EDX diffraction measurements were also taken to pressures up to 105 GPa. Additionally, EDX diffraction measurements of TiO$\sb2$ up to 28 GPa were taken to determine the equations of state of its high-pressure phases, starting with anatase and furtile at atmospheric pressure. (Abstract shortened by UMI.)
Efficacy, safety and quality of life in a multicenter, randomized, placebo-controlled trial of low-dose peanut oral immunotherapy in children with peanut allergy
Creators: name: Blumchen, Katharina
name: Trendelenburg, Valérie
name: Ahrens, Frank
name: Gruebl, Armin
name: Hamelmann, Eckard
name: Hansen, Gesine
name: Heinzmann, Andrea
name: Nemat, Katja
name: Holzhauser, Thomas
name: Roeder, Martin
name: Rosenfeld, Leonard
name: Hartmann, Oliver
name: Niggemann, Bodo
name: Beyer, Kirsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: oral immunotherapy
subject: tolerance
subject: induction
subject: children
subject: peanut allergy
subject: desensitization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Only 2 small placebo-controlled trials on peanut oral immunotherapy (OIT) have been published. OBJECTIVE: We examined the efficacy, safety, immunologic parameters, quality of life (QOL), and burden of treatment (BOT) of low-dose peanut OIT in a multicenter, double-blind, randomized placebo-controlled trial. METHODS: A total of 62 children aged 3 to 17 years with IgE-mediated, challenge-proven peanut allergy were randomized (1:1) to receive peanut OIT with a maintenance dose of 125 to 250 mg peanut protein or placebo. The primary outcome was the proportion of children tolerating 300 mg or more peanut protein at oral food challenge (OFC) after 16 months of OIT. We measured the occurrence of adverse events (AEs), immunologic changes, and QOL before and after OIT and BOT during OIT. RESULTS: Twenty-three of 31 (74.2%) children of the active group tolerated at least 300 mg peanut protein at final OFC compared with 5 of 31 (16.1%) in the placebo group (P < .001). Thirteen of 31 (41.9%) children of the active versus 1 of 31 (3.2%) of the placebo group tolerated the highest dose of 4.5 g peanut protein at final OFC (P < .001). There was no significant difference between the groups in the occurrence of AE-related dropouts or in the number, severity, and treatment of objective AEs. In the peanut-OIT group, we noted a significant reduction in peanut-specific IL-4, IL-5, IL-10, and IL-2 production by PBMCs compared with the placebo group, as well as a significant increase in peanut-specific IgG4 levels and a significant improvement in QOL; 86% of children evaluated the BOT positively. DISCUSSION: Low-dose OIT is a promising, effective, and safe treatment option for peanut-allergic children, leading to improvement in QOL, a low BOT, and immunologic changes showing tolerance development.
Histopathological Changes in the Kidney following Congestive Heart Failure by Volume Overload in Rats
Creators: name: Aboryag, Noureddin B.
name: Mohamed, Doaa M.
name: Dehe, Lukas
name: Shaqura, Mohammed
name: Treskatsch, Sacha
name: Shakibaei, Mehdi
name: Schaefer, Michael
name: Mousa, Shaaban A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background. This study investigated histopathological changes and apoptotic factors that may be involved in the renal damage caused by congestive heart failure in a rat model of infrarenal aortocaval fistula (ACF). Methods. Heart failure was induced using a modified approach of ACF in male Wistar rats. Sham-operated controls and ACF rats were characterized by their morphometric and hemodynamic parameters and investigated for their histopathological, ultrastructural, and apoptotic factor changes in the kidney. Results. ACF- induced heart failure is associated with histopathological signs of congestion and glomerular and tubular atrophy, as well as nuclear and cellular degeneration in the kidney. In parallel, overexpression of proapoptotic Bax protein, release of cytochrome C from the outer mitochondrial membrane into cell cytoplasm, and nuclear transfer of activated caspase 3 indicate apoptotic events. This was confirmed by electron microscopic findings of apoptotic signs in the kidney such as swollen mitochondria and degenerated nuclei in renal tubular cells. Conclusions. This study provides morphological evidence of renal injury during heart failure which may be due to caspase-mediated apoptosis via overexpression of proapoptotic Bax protein, subsequent mitochondrial cytochrome C release, and final nuclear transfer of activated caspase 3, supporting the notion of a cardiorenal syndrome.
title: ÐÑÐ¾ÑÑ-ÐºÑÐ»ÑÑÑÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐµÐºÑÑÐ¾Ð² Ð´Ð»Ñ ÑÑÐµÐ½Ð¸Ñ Ð½Ð° Ð·Ð°Ð½ÑÑÐ¸ÑÑ Ð¿Ð¾ ÑÑÑÑÐºÐ¾Ð¼Ñ ÑÐ·ÑÐºÑ ÐºÐ°Ðº Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½Ð¾Ð¼Ñ Ñ ÐºÐ¸ÑÐ°Ð¹ÑÐºÐ¸Ð¼Ð¸ ÑÑÑÐ´ÐµÐ½ÑÐ°Ð¼Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Cross-cultural analysis of texts for reading in Russian as a foreign language classes with Chinese students
Creators: name: ÐÐ°Ð½ Ð¡Ð¸Ð½Ð±Ð¾
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÑÑÐ´ÐµÐ½Ñ
ÑÑÑÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
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ÑÑÐµÐ½Ð¸Ðµ
Ð¼ÐµÐ¶ÐºÑÐ»ÑÑÑÑÐ½Ð°Ñ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ñ
student
Russian language
cross-cultural analysis
exercise
reading
intercultural communication

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description: This paper examines the cross-cultural analysis of texts for reading in classes on Russian as a foreign language with Chinese students. General concepts on the chosen topic are given and a theoretical framework is presented, including cross-cultural aspects of reading and perception of the text. A comparative analysis of educational and methodological materials for teaching Chinese students the Russian language, including reading texts and related exercises, has been carried out. As a result of the research, methodological recommendations and exercises were developed that take into account the cross-cultural characteristics of Chinese students. This includes the adaptation of texts for reading, as well as the development of tasks aimed at improving the understanding and analysis of texts.
Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade
Creators: name: Atkinson, Sara Marie
name: Hoffmann, Ute
name: Hamann, Alf
name: Bach, Emil
name: Danneskiold-Samsøe, Niels Banhos
name: Kristiansen, Karsten
name: Serikawa, Kyle
name: Fox, Brian
name: Kruse, Kim
name: Haase, Claus
name: Skov, Søren
name: Nansen, Anneline
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Rheumatoid arthritis
subject: Regulatory T cells, IL-1
subject: Neutrophils
subject: C57BL/6
subject: ACPA
subject: Microbiota
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchronised onset, 100% penetrance and low variation. We investigate the role of regulatory T cells (Tregs) in DTHA through selective depletion of Tregs and the role of IL-17 in connection with Treg depletion. Given the relevance of Tregs in RA, and the possibility of developing Treg-directed therapies, this approach could be relevant for advancing the understanding of Tregs in inflammatory arthritis. Selective depletion of Tregs was achieved using a Foxp3-DTR-eGFP mouse, which expresses the diphtheria toxin receptor (DTR) and enhanced green fluorescent protein (eGFP) under control of the Foxp3 gene. Anti-IL-17 monoclonal antibody (mAb) was used for IL-17 blockade. Numbers and activation of Tregs increased in the paw and its draining lymph node in DTHA, and depletion of Tregs resulted in exacerbation of disease as shown by increased paw swelling, increased infiltration of inflammatory cells, increased bone remodelling and increased production of inflammatory mediators, as well as increased production of anti-citrullinated protein antibodies. Anti-IL-17 mAb treatment demonstrated that IL-17 is important for disease severity in both the presence and absence of Tregs, and that IL-17 blockade is able to rescue mice from the exacerbated disease caused by Treg depletion and caused a reduction in RANKL, IL-6 and the number of neutrophils. We show that Tregs are important for the containment of inflammation and bone remodelling in DTHA. To our knowledge, this is the first study using the Foxp3-DTR-eGFP mouse on a C57BL/6 background for Treg depletion in an arthritis model, and we here demonstrate the usefulness of the approach to study the role of Tregs and IL-17 in arthritis.
Investigating digital design tutorial videos online
Creators: name: Walker, Adam Douglas
Publisher: name: Swinburne
Year: 2024

description: This thesis investigates the emergence of an online phenomenon and its relationship with digital design. This phenomenon involves geographically distributed individuals sharing information related to a craft or professional practice. In this instance design practice, via video content online, in the form of a tutorial video. Creation of this content involves designers and hobbyists, who are using design applications, recording them and then sharing online the digital processes they have recorded. These digital processes are then viewed by hundreds of thousands of other designers. This content and interaction with it is studied using a content analysis and social network analysis.
Le bonheur de l'homme chez Pascal.
Creators: name: Izaguirre, Mónica.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Philosophy.

description: L'oeuvre des Pensées de Blaise Pascal constitue le cadre dans lequel nous avons essayé de donner une réponse à la question que nous dégageons de la perspective anthropologique du texte: l'homme de Pascal, retrouve-t-il le bonheur? Le développement de l'argumentation qui vise à répondre à cette question est présenté en trois sections: La première, La Misère, porte sur l'analyse des traits qui décrivent la condition malheureuse de l'homme. La deuxième, La Grandeur, présente les caractéristiques de la nature humaine qui mettent en évidence l'existence d'une première nature chez l'homme, cette nature étant imperceptible aux yeux de l'incroyant. La troisième partie, Le Bonheur, vise à analyser la façon par laquelle ces deux états de la nature humaine, Misère-Grandeur, qui d'abord se dessinent comme contraires, trouvent un point d'équilibre permettant à l'homme d'atteindre un bonheur dont il n'avait jamais soupçonné, mais qui pourtant lui était propre. La réponse au problème initial se situe donc dans le cadre des perspectives optimistes des Pensées .
A review of person-centred fall prevention: A proposal for using augmented reality to assist with co-designing home modifications as part of a service improvement strategy
Creators: name: Lo Bianco, Michael
Publisher: name: Swinburne
Year: 2024

description: The thesis investigates older adult fall prevention. The research focuses on how to use goals as design drivers to curb home modification compliance problems.
Control theory and multiple qualitative methods are employed to investigate: how should fall prevention home modification services be delivered to achieve person-centredness?
Outcomes include a control driven person-centred fall prevention service model and an augmented reality home modification design application.
Results demonstrate that active engagement in the design process is perceived to provide older adults with greater control within fall prevention services with opportunities to raise compliancy and decrease in falls through personalised fall prevention recommendations.
Enhance the Discovery and Interoperability of Culturally Rich Information: the Chinese Women Poets WikiProject
Creators: name: Jiang, Jing
name: Huang, Jie
name: Liao, Yan (Clara)
name: Liu-Spencer, Hsianghui
name: Deng, Sai
name: Zhu, Lihong
name: Li, Xiaoli
name: Heng, Greta
name: Xu, Amanda Z.
Publisher: name: Washington State University
Year: 2022
Subjects: linked data
Poets, Chinese
Knowledge Management
Library Technical Services

description: Traditionally, special collections such as culture and heritage collections and their name authority data were cataloged using local cataloging standards with limited data interoperability. The library community has questioned for a number of years how to increase the accessibility and visibility of cultural heritage information stored in centralized databases. Wikidata, a global and open knowledge repository of structured data serving as a hub for linking resources, has emerged as one of possible solutions to library data silo issues. A group of Chinese American librarians from several institutions formed a WikiProject team: Chinese Culture and Heritage group in 2020 to study Wikidata. The group hoped to explore the potential of Wikidata, contribute to the diversity of data in Wikidata which has been increasingly utilized in libraries’ discovery systems, and seek collaboration opportunities. Its primary focus is to create and enhance Wikidata items that showcase Chinese culture and heritage information. This poster will present an overview of the Chinese Women Poets Wikiproject, the first project the group has embarked on, that uses OpenRefine and PyWikibot to enhance over 4,000 Chinese women poets’ names in Wikidata. In addition, the presenters will discuss the challenges and the benefits of the project as well as their future work.
The Function of Inosine-5’-Monophosphate Dehydrogenase’s Bateman Domain in Escherichia coli
Creators: name: McDonnell, Sabrina
Publisher: name: Brandeis University
Year: 2018

description: Inosine 5’-monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting conversion of inosine 5’-monophosphate (IMP) to xanthosine 5’-monophosphate (XMP) in the de novo purine biosynthesis pathway. Overexpression of the protein is linked to the proliferation of diseased cells, and inhibitors of IMPDH have been used as anticancer, antiviral, and immunosuppressive treatments. IMPDH is a tetramer and each monomer has two domains: a catalytic domain and a Bateman domain. The function of the Bateman domain is currently unknown. The enzyme remains catalytically active when the Bateman domain is replaced with a short peptide scar (ΔCBS). Mutations in the Bateman domain of human IMPDH 1 have been linked to hereditary diseases including retinitis pigmentosa. Understanding the function of the Bateman domain in E. coli will shed light on IMPDH’s extracatalytic functions. I constructed E. coli strains that can endogenously express Strep-II tagged IMPDH and IMPDHΔCBS and used affinity purification to test for the presence of binding partners. E. coli cells were harvested during exponential growth and incubated with formaldehyde to chemically cross-link protein-protein and protein-nucleotide interactions prior to lysis. Western blots of IMPDH and IMPDHΔCBS from cross-linked lysates revealed cross-link dependent band shifts that corresponded with the molecular weight of their respective dimer, trimer, and tetramer. There was also a cross-link dependent shift of the wild-type IMPDH monomer that was absent in the IMPDHΔCBS sample, which indicates that the shift was dependent on an interaction with the Bateman domain. Mass spectrometry was inconclusive for determining a protein-binding partner for the Bateman domain, but both the WT tagged and ΔCBS tagged samples contained GMP reductase (GMPR) and adenosine deaminase. Additional research is required to identify the function of these interactions and the molecule(s) that interact with the Bateman domain.
Congregation of the Sisters of Mercy (Ireland): Analysis of the governance structures.
Creators: name: Lyons, Mary.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: History, Church.

description: This dissertation analyses the evolution of the governance structures of the Congregation of the Sisters of Mercy (Ireland), since its foundation by Catherine McAuley in Dublin, Ireland, in 1831. The topic is subdivided into four questions: (1) What form of governance did the Congregation of the Sisters of Mercy inherit from its historical roots? (2) What factors prompted the change of governance that had begun to take place in some Irish dioceses as early as 1860? (3) What considerations motivated the eventual move towards a centralised form of government in 1994? (4) What are the implications of this development? We have attempted to answer these questions in four organically related chapters by, first of all, tracing the growth and expansion of the Congregation in its historical and social context, and then examining the various changes that were implemented in its governance structures between 1841 and 1994, in response to ecclesiastical legislation. Chapter I situates the foundation of the Congregation of the Sisters of Mercy in nineteenth century Ireland as we look at the political, economic, and ecclesiastical contexts. Chapter II examines the ecclesiastical legislation that pertained especially to apostolic religious congregations of women in the twentieth century. In Chapter III we trace the restructuring of the governance structures of the Congregation in response to the Second Vatican Council's mandate for adaptation and renewal. Chapter IV examines the structure of the new congregational government that came into being in July 1994. Finally, a number of conclusions to be drawn from unification are proposed. These concern structures, internationality, inculturation, collaboration in ministry, and new forms of membership.
Integrated Pest Management, 2023 Quarter 4 Newsletter
Creators: name: Washington State University Extension
Publisher: name: Washington State University
Year: 2023
Subjects: Pest Management

description: This newsletter includes: Powdery Mildew, Phylloxera, Spotted Lanternfly in Grape; Role of Biocontrol in Spotted-Wing Drosophila Management; Tilth Conference: IPM in a Changing Climate; Master Gardeners Increase Pollinator Awareness; Breaking Down Barriers to Biodegradable Plastic Mulch Use; Honey Bee Team Has More Tools to Fight Varroa; Harvest Weed Seed Control in Small Grains; Onion Cultivar Trial Results Now Available