cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Holstein Polaron
Creators: name: Bonca, J.
name: Trugman, S. A.
name: Batistic, I.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We describe a variational method to solve the Holstein model for an electron coupled to dynamical, quantum phonons on an infinite lattice. The variational space can be systematically expanded to achieve high accuracy with modest computational resources (12-digit accuracy for the 1d polaron energy at intermediate coupling). We compute ground and low-lying excited state properties of the model at continuous values of the wavevector $k$ in essentially all parameter regimes. Our results for the polaron energy band, effective mass and correlation functions compare favorably with those of other numerical techniques including DMRG, Global Local and exact diagonalization. We find a phase transition for the first excited state between a bound and unbound system of a polaron and an additional phonon excitation. The phase transition is also treated in strong coupling perturbation theory.
description: 24 pages, 11 figures submitted to PRB
Dynamics of Lennard-Jones clusters: A characterization of the activation-relaxation technique
Creators: name: Malek, R.
name: Mousseau, N.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The potential energy surface (PES) of Lennard-Jones clusters is investigated using the activation-relaxation technique (ART). This method defines events in the configurational energy landscape as a two-step process: (a) a configuration is first activated from a local minimum to a nearby saddle-point and (b) is then relaxed to a new minimum. Although ART has been applied with success to a wide range of materials such as a-Si, a-SiO2 and binary Lennard-Jones glasses, questions remain regarding the biases of the technique. We address some of these questions in a detailed study of ART-generated events in Lennard-Jones (LJ) clusters, a system for which much is already known. In particular, we study the distribution of saddle-points, the pathways between configurations, and the reversibility of paths. We find that ART can identify all trajectories with a first-order saddle point leaving a given minimum, is fully reversible, and samples events following the Boltzmann weight at the saddle point.
description: 8 pages, 7 figures in postscript
Strong-coupling perturbation theory for the two-dimensional Bose-Hubbard model in a magnetic field
Creators: name: Niemeyer, M.
name: Freericks, J. K.
name: Monien, H.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The Bose-Hubbard model in an external magnetic field is investigated with strong-coupling perturbation theory. The lowest-order secular equation leads to the problem of a charged particle moving on a lattice in the presence of a magnetic field, which was first treated by Hofstadter. We present phase diagrams for the two-dimensional square and triangular lattices, showing a change in shape of the phase lobes away from the well-known power-law behavior in zero magnetic field. Some qualitative agreement with experimental work on Josephson-junction arrays is found for the insulating phase behavior at small fields.
description: 7 pages, 5 figures included
Symmetries of Celestial Amplitudes
Creators: name: Stieberger, Stephan
name: Taylor, Tomasz R.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Celestial amplitudes provide holographic imprints of four-dimensional scattering processes in terms of conformal correlation functions on a two-dimensional sphere describing Minkowski space at null infinity. We construct the generators of Poincare and conformal groups in the celestial representation and discuss how these symmetries are manifest in the amplitudes.
description: v2: Appendix added with examples. 7 pages
Control of Spin Diffusion and Suppression of the Hanle Effect by the Coexistence of Spin and Valley Hall Effects
Creators: name: Zhang, Xian-Peng
name: Huang, Chunli
name: Cazalilla, Miguel A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In addition to spin, electrons in many materials possess an additional pseudo-spin degree of freedom known as 'valley'. In materials where the spin and valley degrees of freedom are weakly coupled, they can be both excited and controlled independently. In this work, we study a model describing the interplay of the spin and valley Hall effects in such two-dimensional materials. We demonstrate the emergence of an additional longitudinal neutral current that is both spin and valley polarized. The additional neutral current allows to control the spin density by tuning the magnitude of the valley Hall effect. In addition, the interplay of the two effects can suppress the Hanle effect, that is, the oscillation of the nonlocal resistance of a Hall bar device with in-plane magnetic field. The latter observation provides a possible explanation for the absence of the Hanle effect in a number of recent experiments. Our work opens also the possibility to engineer the conversion between the valley and spin degrees of freedom in two-dimensional materials.
description: 15 pages, 2 figures
Adsorption on a periodically corrugated substrate
Creators: name: Rejmer, K.
name: Napiorkowski, M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Mean field analysis of the effective interfacial Hamiltonian shows that with increasing temperature the adsorption on a periodically corrugated substrate can proceed in two steps: first, there is the filling transition in which the depressions of the substrate become partially or completely filled; then there is the wetting transition at which the substrate as a whole becomes covered with a macroscopically thick wetting layer. The actual order and location of both transitions are related to the wetting properties of the corresponding planar substrate and to the form of corrugation. Certain morphological properties of the liquid-vapor interface in the case of a saw-like corrugated substrate are discussed analytically
description: 20 pages, 9 Postscript figures
Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection
Creators: name: Wang, Mingjie
name: Chen, Li
name: Dong, MinHui
name: Li, Jing
name: Zhu, Beidi
name: Yang, Zhitao
name: Gong, Qiming
name: Han, Yue
name: Yu, Demin
name: Zhang, Donghua
name: Zoulim, Fabien
name: Zhang, Jiming
name: Zhang, Xinxin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Few non-invasive models were established for precisely identifying the immune tolerant (IT) phase from chronic hepatitis B (CHB). This study aimed to develop a novel approach that combined next-generation sequencing (NGS) and machine learning algorithms using our recently published viral quasispecies (QS) analysis package. 290 HBeAg positive patients from whom liver biopsies were taken were enrolled and divided into a training group (n=148) and a validation group (n=142). HBV DNA was extracted and QS sequences were obtained by NGS. Hierarchical clustering analysis (HCA) and principal component analysis (PCA) based on viral operational taxonomic units (OTUs) were performed to explore the correlations among QS and clinical phenotypes. Three machine learning algorithms, including K-nearest neighbour, support vector machine, and random forest algorithm, were used to construct diagnostic models for IT phase classification. Based on histopathology, 90 IT patients and 200 CHB patients were diagnosed. HBsAg titres for IT patients were higher than those of CHB patients (p<0.001). HCA and PCA analysis grouped IT and CHB patients into two distinct clusters. The relative abundance of viral OTUs differed mainly within the BCP/precore/core region and was significantly correlated with liver inflammation and fibrosis. For the IT phase classification, all machine-learning models showed higher AUC values compared to models based on HBsAg, APRI, and FIB-4. The relative abundance of viral OTUs reflects the severity of liver inflammation and fibrosis. The novel QS quantitative analysis approach could be used to diagnose IT patients more precisely and reduce the need for liver biopsy.
Additional file 2: of A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable
Creators: name: Cortellini, Alessio
name: Bersanelli, Melissa
name: Buti, Sebastiano
name: Cannita, Katia
name: Santini, Daniele
name: Perrone, Fabiana
name: Giusti, Raffaele
name: Tiseo, Marcello
name: Michiara, Maria
name: Marino, Pietro Di
name: Tinari, Nicola
name: Tursi, Michele De
name: Zoratto, Federica
name: Veltri, Enzo
name: Marconcini, Riccardo
name: Malorgio, Francesco
name: Russano, Marco
name: Anesi, Cecilia
name: Zeppola, Tea
name: Filetti, Marco
name: Marchetti, Paolo
name: Botticelli, Andrea
name: Cappellini, Gian Antonini
name: Galitiis, Federica De
name: Vitale, Maria
name: Rastelli, Francesca
name: Pergolesi, Federica
name: Berardi, Rossana
name: Rinaldi, Silvia
name: Tudini, Marianna
name: Silva, Rosa
name: Annagrazia Pireddu
name: Atzori, Francesco
name: Chiari, Rita
name: Ricciuti, Biagio
name: Giglio, Andrea De
name: Iacono, Daniela
name: Gelibter, Alain
name: Occhipinti, Mario
name: Parisi, Alessandro
name: Porzio, Giampiero
name: Fargnoli, Maria
name: Ascierto, Paolo
name: Ficorella, Corrado
name: Natoli, Clara
Publisher: name: figshare
Year: 2019
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Immune-related adverse events of any grade and G3/G4 immune-related adverse events. (DOCX 15 kb)
Onthophagus hrubanti Balthasar 1955
Creators: name: Bezděk, Aleš
name: Hájek, Jiří
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Onthophagus
Onthophagus hrubanti

description: Onthophagus hrubanti Balthasar, 1955
 Onthophagus hrubanti Balthasar, 1955: 414.
Seven paratypes are deposited in NMPC (ex coll. V. Balthasar):
PARATYPE (J): ‘J. Klapperich / Sarobi, 900 m, am / Kabulfluss, 12.6.52 / O. Afghanistan [p] // Onthophagus / hrubanti n. sp. / Balth. [hw] / Paratypus [p, pink label] // Mus. nat. Pragae / Inv. [p] 65 835 [hw, red label] // Onthophagus J / ramosellus Bat. / Kabakov det.1986 [hw] // Onthophagus (Colob.) / ramosellus BAT. [p]J [hw] / J. SCHEU- ERN det. 1996 [p] // hrubanti Balth. / syn. nov. 96 [hw] / J. SCHEUERN det. [p]’.
PARATYPE (♀): ‘J. Klapperich / Sarobi, 900 m, am / Kabulfluss, 12.6.52 / O. Afghanistan [p] // Onthophagus / hrubanti / n. sp. Balth. [hw] / Paratypus [p, pink label] // Mus. nat. Pragae / Inv. [p] 65 833 [hw, red label] // Onthophagus ♀ / ramosellus Bat. / Kabakov det.1986 [hw] // Onthophagus (Colob.) / ramosellus BAT. [p] ♀ [hw] / J. SCHEU- ERN det. 1996 [p] // hrubanti Balth. / syn. nov. 96 [hw] / J. SCHEUERN det. [p]’.
PARATYPE (♀): ‘J. Klapperich / Sarobi, 900 m, am / Kabulfluss, 12.6.52 / O. Afghanistan [p] // Onthophagus / hrubanti n. sp. / Balth. [hw] / Paratypus [p, pink label] // Mus. nat. Pragae / Inv. [p] 65 831 [hw, red label] // Onthophagus (Colob.) / ramosellus BAT. [p] ♀ [hw] / J. SCHEUERN det. 1996 [p] // hrubanti Balth. / syn. nov. 96 [hw] / J. SCHEUERN det. [p]’.
PARATYPE (♀): ‘J. Klapperich / Sarobi, 900 m, am / Kabulfluss, 12.6.52 / O. Afghanistan [p] // Onthophagus / hrubanti n. sp. / ♀ Balth. [hw] / Paratypus [p, pink label] // Mus. nat. Pragae / Inv. [p] 65 834 [hw, red label] //
Onthophagus (Colob.) / ramosellus BAT. [p] ♀ [hw] / J. SCHEUERN det. 1996 [p] // hrubanti Balth. / syn. nov. 96 [hw] / J. SCHEUERN det. [p]’.
PARATYPE (♀): ‘J. Klapperich / Sarobi, 900 m, am / Kabulfluss, 12.6.52 / O. Afghanistan [p] // Onthophagus / hrubanti n. sp. / ♀ Balth. [hw] / Paratypus [p, pink label] // Mus. nat. Pragae / Inv. [p] 65 832 [hw, red label] // Onthophagus (Colob.) / ramosellus BAT. [p] ♀ [hw] / J. SCHEUERN det. 1996 [p] // hrubanti Balth. / syn. nov. 96 [hw] / J. SCHEUERN det. [p]’.
PARATYPES (2 unsexed specimens): ‘J. Klapperich / Sarobi, 900 m, am / Kabulfluss, 12.6.52 / O. Afghanistan [p]’.
 Current status. Junior subjective synonym of Onthophagus (Colobonthophagus) ramosellus Bates, 1891, see KABAKOV (2006).
description: Published as part of Bezděk, Aleš & Hájek, Jiří, 2013, Catalogue of type specimens of beetles (Coleoptera) deposited in the National Museum, Prague, Czech Republic, pp. 387-442 in Acta Entomologica Musei Nationalis Pragae 53 (1) on pages 407-408, DOI: 10.5281/zenodo.5739743
Quantitative analysis of losses close to a d-wave open-channel Feshbach resonance in Potassium 39
Creators: name: Fouche, Lauriane
name: Boissé, Amaudric
name: Berthet, Guillaume
name: Lepoutre, Steven
name: Simoni, Andrea
name: Bourdel, Thomas
Publisher: name: arXiv
Year: 2018
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We study atom losses associated to a previously unreported magnetic Feshbach resonance in potassium 39. This resonance is peculiar in that it presents $d$-wave character both in the open and in the closed channels, directly coupled by the dominant spin-exchange interaction. The losses associated to a $d$-wave open-channel resonance present specific signatures such as strong temperature dependance and anisotropic line shapes. The resonance strength and position depend on the axial projection of the orbital angular momentum of the system and are extracted from rigorous multichannel calculations. A two-step model, with an intermediate collision complex being ejected from the trap after collisions with free atoms, permits to reproduce the observed dependance of the loss rate as a function of temperature and magnetic field.
Using Fludarabine to Reduce Exposure to Alkylating Agents in Children with Sickle Cell Disease Receiving Busulfan, Cyclophosphamide, and Antithymocyte Globulin Transplant Conditioning: Results of a Dose De-Escalation Trial
Creators: name: Kasow, Kimberly A.
name: Dioguardi, Jacqueline Lagerlof
name: Brown, Clark
name: Hale, Greg
name: Horan, John T.
name: Benton, Melody
name: Nieder, Michael
name: Abraham, Allistair
name: Shelman, Chiani
name: Grizzle, Audrey
name: Chiang, Kuang-Yueh
name: Kanter, Julie
name: Haight, Ann
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: AbstractHigh-dose busulfan, cyclophosphamide, and antithymocyte globulin (BU-CY-ATG) is the most commonly used conditioning regimen in HLA-matched related hematopoietic cell transplantation for children with sickle cell disease. Disease-free survival with this regimen is now approximately 95%; however, it produces significant morbidity. We hypothesized we could create a less toxic regimen by adding fludarabine (FLU) to BU-CY-ATG and reduce the dosages of busulfan and cyclophosphamide. We conducted a multicenter dose de-escalation trial with the objective of decreasing the doses of busulfan and cyclophosphamide by 50% and 55%, respectively. Using day +28 donor-predominant chimerism as a surrogate endpoint for sustained engraftment, we completed the first 2 of 4 planned levels, enrolling 6 patients at each and reducing the total dose of cyclophosphamide from 200 mg/kg to 90 mg/kg. On the third level, which involved a reduction of i.v. busulfan from 12.8 mg/kg to 9.6 mg/kg, the first 2 patients had host-predominant T cell chimerism, which triggered trial-stopping rules. All 14 patients survive disease-free. No patients suffered severe regimen-related toxicity. Our results suggest BU-FLU-CY-ATG using lower dose CY could be a less toxic yet effective regimen. Further evaluation of this regimen in a full-scale clinical trial is warranted.
Estudo sobre o gerenciamento dos resíduos de serviços de saúde no nordeste brasileiro
Creators: name: Ferreira, Luan Prince
name: Merola, Lucca Pereira
name: Vieira, Mirella De Sousa
name: Silva, Thaynara Rodrigues
name: Milagre, Selma Terezinha
Publisher: name: Zenodo
Year: 2019
Subjects: Resíduos de Serviços de Saúde
Gerenciamento de Resíduos
Estabelecimento Assistencial de Saúde de Saúde
Educação Ambiental

description: O Plano de Gerenciamento de Resíduos de Serviços de Saúde (PGRSS) é uma ferramenta que apresenta as etapas do processo de gerenciamento de resíduos de Estabelecimentos Assistenciais de Saúde (EAS), desde a segregação até a disposição final. O presente trabalho trata de uma revisão da literatura que propõe analisar, comparar e avaliar a situação do gerenciamento de resíduos da região nordeste do Brasil. Englobando todas as etapas deste processo, da segregação inicial ao tratamento. Para isso foram escolhidos 14 artigos científicos, entre teses, dissertações e artigos completos, que retratam a realidade dessa região. A busca por esses estudos foi realizada nas plataformas, Scholar Google e Scielo, e em websites e repositórios de universidades com as palavras chave Gestão, Resíduos, Saúde + Nordeste. Foi possível analisar dados referentes à quantidade de resíduos em saúde produzidos e sobre o conhecimento dos profissionais envolvidos. Observou-se que a região nordeste conta com estabelecimentos em condições precárias de segregação de resíduos de saúde. Sugere-se aumentar a cobrança dos gestores desses estabelecimentos, melhorar o treinamento dos profissionais de saúde sobre o assunto, criar ou atualizar PGRSS e dedicar uma equipe ao controle e acompanhamento das atividades de segregação, acondicionamento, descarte e tratamento dos resíduos.
Sidedness of reconstituted calcium channels from muscle transverse tubules as determined by D600 and D890 blockade
Creators: name: Coronado, R.
name: Affolter, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: The verapamil-type calcium antagonist, D600, and its charged quaternary derivative, D890, were used to assess the sidedness of blockade in single calcium channels reconstituted from purified transverse tubules of skeletal muscle. Spontaneous single channel openings were induced with the agonist Bay-K8644 and recordings were made in a two-chamber planar bilayer setup so that drugs could be delivered to either side of the channel. Micromolar drug addition resulted in a greater than 10-fold decrease in probability of open channel events (po) without a significant change in single channel currents. Changes in po occurred in parallel with changes in mean open time and both parameters could be titrated with a similar IC50. At pH 7.2, cis or trans D600 blocked with an IC50 of 5 microM but for D890 the IC50 was cis 3 microM and trans greater than 75 microM (cis is the intracellular-equivalent side as defined by the voltage-dependent activation). The asymmetry of D890 blockade indicates that the drug can readily gain access to the blocking site from the aqueous phase adjacent to the inner but not extracellular end of the channel.
Bulk and edge correlations in the compressible half-filled quantum Hall state
Creators: name: Milovanović, Milica V.
name: Shimshoni, Efrat
Publisher: name: arXiv
Year: 1998
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study bulk and edge correlations in the compressible half-filled state, using a modified version of the plasma analogy. The corresponding plasma has anomalously weak screening properties, and as a consequence we find that the correlations along the edge do not decay algebraically as in the Laughlin (incompressible) case, while the bulk correlations decay in the same way. The results suggest that due to the strong coupling between charged modes on the edge and the neutral Fermions in the bulk, reflected by the weak screening in the plasma analogue, the (attractive) correlation hole is not well defined on the edge. Hence, the system there can be modeled as a free Fermi gas of {\em electrons} (with an appropriate boundary condition). We finally comment on a possible scenario, in which the Laughlin-like dynamical edge correlations may nevertheless be realized.
description: package now includes the file epsfig.sty, needed to incorporate properly the 8 magnificent figures
Additional file 2: of Structural and functional divergence of the Mpc1 genes in wheat and barley
Creators: name: Strygina, Ksenia
name: Khlestkina, Elena
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Putative cis-acting regulatory elements identified in the Mpc1 promoters. Promoter analysis was performed using New PLACE database. “+” – coding strand, “–” – template strand. (PDF 326 kb)
Constraints on the Quasiparticle Density of States in High-$T_c$ Superconductors
Creators: name: Cren, T.
name: Roditchev, D.
name: Sacks, W.
name: Klein, J.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In this Letter we present new tunneling data on YBa$_2$Cu$_3$O$_7$ thin films by low temperature scanning tunneling spectroscopy. Unusual peak-dip-hump features, previously reported in Bi$_2$Sr$_2$CaCu$_2$O$_{8+δ}$, are also found in YBa$_2$Cu$_3$O$_7$. To analyse these common signatures we propose a new heuristic model in which, in addition to the d-wave symmetry, the gap function is energy dependent. A simple expression for the quasiparticle density of states is derived, giving an excellent agreement with the experiment. The dynamics of the quasiparticle states and the energy scales involved in the superconducting transition are discussed.
description: 4 page Letter with 3 figures
Spectral and Temporal Variability of Earth Observed in Polarization
Creators: name: Sterzik, Michael F.
name: Bagnulo, Stefano
name: Stam, Daphne M.
name: Emde, Claudia
name: Manev, Mihail
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present a comprehensive set of spectropolarimetric observations of Earthshine as obtained by FORS2 at the VLT for phase angles from 50degree to 135degree (Sun-Earth-Moon angle), covering a spectral range from 430nm to 920nm. The degree of polarization in BVRI passbands, the differential polarization vegetation index, and the equivalent width of the O2A polarization band around 760nm are determined with absolute errors around 0.1 percent in the degree of polarization. Earthshine polarization spectra are corrected for the effect of depolarization introduced by backscattering on the lunar surface, introducing systematic errors of the order of 1 percent in the degree of polarization. Distinct viewing sceneries such as observing the Atlantic or Pacific side in Earthshine yield statistically different phase curves. The equivalent width defined for the O2A band polarization is found to vary from -5nm to +2nm. A differential polarized vegetation index is introduced and reveals a larger vegetation signal for those viewing sceneries that contain larger fractions of vegetated surface areas. We corroborate the observed correlations with theoretical models from the literature, and conclude that the Vegetation Red Edge(VRE) is a robust and sensitive signature in polarization spectra of planet Earth. The overall behaviour of polarization of planet Earth in the continuum and in the O2A band can be explained by existing models. Biosignatures such as the O2A band and the VRE are detectable in Earthshine polarization with a high degree of significance and sensitivity. An in-depth understanding of Earthshines temporal and spectral variability requires improved models of Earths biosphere, as a prerequisite to interpret possible detections of polarised biosignatures in earthlike exoplanets in the future.
description: 19 pages, 14 figures, 3 tables
Dynamics of SiO$_2$ glasses
Creators: name: Oligschleger, C.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Results on the dynamics of silica are presented: vibrations and relaxations. Using molecular dynamics, glass structures are generated by rapidly quenching melts below the glass transition. For the local minima of the structures the vibrational density of states is determined, the structures of the eigenmodes are analyzed, and the influence of the single components is discussed. Relaxations are studied in both amorphous SiO$_2$ and silica melts. Our main focus is on the type of relaxation, i.e., whether the main contributions are caused by small atomic displacements, or by bond-breaking processes, e.g. creation and annihilation of dangling bonds. The eigenvector of the relaxations is found to be similar to the low-frequency one.
description: 28 pages + 24 eps-files
Membrane Modulates Affinity for Calcium Ion to Create an Apparent Cooperative Binding Response by Annexin a5
Creators: name: Rannikko, Anika M.
name: Jaworski, Samantha R.
name: Rice, Anne M.
name: Knutson, Kristofer J.
name: Gauer, Jacob W.
name: Hinderliter, Anne
name: Lentz, Barry R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Isothermal titration calorimetry was used to characterize the binding of calcium ion (Ca2+) and phospholipid to the peripheral membrane-binding protein annexin a5. The phospholipid was a binary mixture of a neutral and an acidic phospholipid, specifically phosphatidylcholine and phosphatidylserine in the form of large unilamellar vesicles. To stringently define the mode of binding, a global fit of data collected in the presence and absence of membrane concentrations exceeding protein saturation was performed. A partition function defined the contribution of all heat-evolving or heat-absorbing binding states. We find that annexin a5 binds Ca2+ in solution according to a simple independent-site model (solution-state affinity). In the presence of phosphatidylserine-containing liposomes, binding of Ca2+ differentiates into two classes of sites, both of which have higher affinity compared with the solution-state affinity. As in the solution-state scenario, the sites within each class were described with an independent-site model. Transitioning from a solution state with lower Ca2+ affinity to a membrane-associated, higher Ca2+ affinity state, results in cooperative binding. We discuss how weak membrane association of annexin a5 prior to Ca2+ influx is the basis for the cooperative response of annexin a5 toward Ca2+, and the role of membrane organization in this response.
Targeted Inactivation of Mdm2 RING Finger E3 Ubiquitin Ligase Activity in the Mouse Reveals Mechanistic Insights into p53 Regulation
Creators: name: Lindström, Mikael S.
name: Bhat, Krishna P.
name: Godfrey, Virginia L.
name: Zhang, Yanping
name: Mao, Hua
name: Clegg, Hilary V.
name: Evan, Gerard I.
name: Itahana, Koji
name: Jin, Aiwen
name: Itahana, Yoko
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: It is believed that Mdm2 suppresses p53 in two ways: transcriptional inhibition by direct binding, and degradation via its E3 ligase activity. To study these functions physiologically, we generated mice bearing a single-residue substitution (C462A) abolishing the E3 function without affecting p53 binding. Unexpectedly, homozygous mutant mice died before E7.5, and deletion of p53 rescued the lethality. Furthermore, reintroducing a switchable p53 by crossing with mice surprisingly demonstrated that the mutant Mdm2 was rapidly degraded in a manner indistinguishable from that of the wild-type Mdm2. Hence, our data indicate that (1) the Mdm2-p53 physical interaction, without Mdm2-mediated p53 ubiquitination, cannot control p53 activity sufficiently to allow early mouse embryonic development, and (2) Mdm2's E3 function is not required for Mdm2 degradation.
THE FORMATION OF MODERN GLOBAL BALANCE AND INTERNATIONAL DIPLOMATIC RELATIONS: CHALLENGES AND OPPORTUNITIES
Creators: name: Sayfullayeva, Marjona
Publisher: name: Zenodo
Year: 2025

description: The international relations system is currently undergoing significant transformations. The formation of global balance, the changing centers of power in world politics and the clash of geopolitical interests have led to the emergence of a new dimension in international diplomatic relations. This article analyzes the development of contemporary diplomacy tools, the role of international organizations and the global threats influencing the formation of intergovernmental relations. Specifically, issues such as climate change, security concerns, economic crises and the influence of artificial intelligence on political decision-making processes are examined in terms of their impact on modern diplomatic communication. Additionally, the article explores the potential of international cooperation, regional integration and peace diplomacy in achieving global balance. It argues that achieving stability in today’s world requires mutual trust, open communication and a balanced approach to foreign policy among nations.
Additional file 1: of A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable
Creators: name: Cortellini, Alessio
name: Bersanelli, Melissa
name: Buti, Sebastiano
name: Cannita, Katia
name: Santini, Daniele
name: Perrone, Fabiana
name: Giusti, Raffaele
name: Tiseo, Marcello
name: Michiara, Maria
name: Marino, Pietro Di
name: Tinari, Nicola
name: Tursi, Michele De
name: Zoratto, Federica
name: Veltri, Enzo
name: Marconcini, Riccardo
name: Malorgio, Francesco
name: Russano, Marco
name: Anesi, Cecilia
name: Zeppola, Tea
name: Filetti, Marco
name: Marchetti, Paolo
name: Botticelli, Andrea
name: Cappellini, Gian Antonini
name: Galitiis, Federica De
name: Vitale, Maria
name: Rastelli, Francesca
name: Pergolesi, Federica
name: Berardi, Rossana
name: Rinaldi, Silvia
name: Tudini, Marianna
name: Silva, Rosa
name: Annagrazia Pireddu
name: Atzori, Francesco
name: Chiari, Rita
name: Ricciuti, Biagio
name: Giglio, Andrea De
name: Iacono, Daniela
name: Gelibter, Alain
name: Occhipinti, Mario
name: Parisi, Alessandro
name: Porzio, Giampiero
name: Fargnoli, Maria
name: Ascierto, Paolo
name: Ficorella, Corrado
name: Natoli, Clara
Publisher: name: figshare
Year: 2019
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: List of oncological institutions of the study. (DOCX 15 kb)
Inherent structures and non-equilibrium dynamics of 1D constrained kinetic models: a comparison study
Creators: name: Crisanti, A.
name: Ritort, F.
name: Rocco, A.
name: Sellitto, M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: e discuss the relevance of the Stillinger and Weber approach to the glass transition investigating the non-equilibrium behavior of models with non-trivial dynamics, but with simple equilibrium properties. We consider a family of 1D constrained kinetic models, which interpolates between the asymmetric chain introduced by Eisinger and Jäckle [Z. Phys. {\bf B84}, 115 (1991)] and the symmetric chain introduced by Fredrickson and Andersen [Phys. Rev. Lett {\bf 53}, 1244 (1984)], and the 1D version of the Backgammon model [Phys. Rev. Lett. {\bf 75}, 1190 (1995)]. We show that the configurational entropy obtained from the inherent structures is the same for all models irrespective of their different microscopic dynamics. We present a detailed study of the coarsening behavior of these models, including the relation between fluctuations and response. Our results suggest that any approach to the glass transition inspired by mean-field ideas and resting on the definition of a configurational entropy must rely on the absence of any growing characteristic coarsening pattern.
description: 32 pages, 28 figures, RevTeX
The global stability of M33: still a puzzle
Creators: name: Sellwood, J. A.
name: Shen, Juntai
name: Li, Zhi
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The inner disc of the local group galaxy M33 appears to be in settled rotational balance, and near IR images reveal a mild, large-scale, two-arm spiral pattern with no strong bar. We have constructed N-body models that match all the extensive observational data on the kinematics and surface density of stars and gas in the inner part of M33. We find that currently favoured models are unstable to the formation of a strong bar of semi-major axis 2 < a_B < 3 kpc within 1 Gyr, which changes the dynamical properties of the models to become inconsistent with the current, apparently well-settled, state. The formation of a bar is unaffected by how the gas component is modelled, by increasing the mass of the nuclear star cluster, or by making the dark matter halo counter-rotate, but it can be prevented by either reducing the mass-to-light ratio of the stars to Upsilon_V ~ 0.6 or Upsilon_K ~ 0.23 in solar units or by increasing the random motions of the stars. Also a shorter and weaker bar results when the halo is rigid and unresponsive. However, all three near-stable models support multi-arm spirals, and not the observed large-scale bi-symmetric spiral. A two-arm spiral pattern could perhaps be tidally induced, but such a model would require an implausibly low mass disc to avoid a bar and there is no visible culprit. Thus the survival of the current state of this exceptionally well-studied galaxy is not yet understood. We also suspect that many other unbarred galaxies present a similar puzzle.
description: 15 pages, 8 figures, to appear in MNRAS. A nymber of revisions from v1
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
Creators: name: Morham, Scott G.
name: Chulada, Patricia C.
name: Kim, H.S.
name: Kluckman, Kimberly D.
name: Lee, Christopher A.
name: Goulding, Eugenia H.
name: Loftin, Charles D.
name: Ghanayem, Burhan I.
name: Mahler, Joel F.
name: Smithies, Oliver
name: Tiano, Howard F.
name: Langenbach, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: AbstractCyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory drugs. To study the physiological roles of the individual isoforms, we have disrupted the mouse Ptgs1 gene encoding COX-1. Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% of wild type. The homozygous mutant mice have reduced platelet aggregation and a decreased inflammatory response to arachidonic acid, but not to tetradecanoyl phorbol acetate. Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2.
The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system
Creators: name: Heale, Shaun M.
name: Petes, Thomas D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: AbstractSimple repetitive tracts of DNA are unstable in all organisms thus far examined. In the yeast S. cerevisiae, we show that a 51 by poly(GT) tract alters length at a rate of about 10−5 per cell division. Insertion of a single variant repeat (either AT or CT) into the middle of the poly(GT) tract results in 100-fold stabilization. This stabilization requires the DNA mismatch repair system. Alterations within tracts with variant repeats occur more frequently on one side of the interruption than on the other. The stabilizing effects of variant repeats and polarity of repeat alterations have also been observed in trinucleotide repeats associated with certain human diseases.
title: Thermal Characterization of Carbon Monoxide Oxidation Catalysts Using Thermogravimetric Analysts and Differential Scanning Calorimetry
Creators: name: Bartgis, Rene A.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1991

description: Catalysts composed of platinum and/or palladium on tin (IV) oxide supports, with and without silica gel, as well as catalysts composed of gold on manganese oxide, have been developed for the recombination of carbon monoxide and oxygen to form carbon dioxide for use in carbon dioxide lasers. A thermogravimetric method and a differential scanning calorimetric method have been developed for the thermal characterization of these catalysts. The mass loss data and the enthalpy changes determined as the catalysts lost water were then related to existing activity data for these catalysts. No relationship was found between the thermal data and the activity data.
Thermal width of the Higgs boson in hot QCD matter
Creators: name: Ghiglieri, Jacopo
name: Wiedemann, Urs Achim
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Following Caron-Huot and combining results for the thermal dependence of spectral functions at large time-like momenta, we write an explicit expression for the thermal width of the Higgs boson to $\mathcal{O}(α_\mathrm{s})$ for $T \ll M_H$. It is an $\mathcal{O}( α_\mathrm{s} (T/M_H)^4 )$ correction for $H\to gg$ and $H\to q\bar{q}$. We also compile corresponding results for the thermal width of the $Z$-boson, and we recall which generic structures of the field theory, accessible via the operator product expansion, fix the $T/M$-dependence of the decay of heavy particles.
description: 5 pages plus appendices. v2: minor modifications, version accepted for publication in PRD
Additional file 1: of Structural and functional divergence of the Mpc1 genes in wheat and barley
Creators: name: Strygina, Ksenia
name: Khlestkina, Elena
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: A. The exon-intronic structure for Mpc1 genes of Triticeae tribe. B. The multiple sequence alignment of promotor sequences of HvMpc1-H3. The alignment was performed using MultAlin program. Red is high consensus colour, blue is low consensus colour, black is neutral colour. (PDF 71 kb)
Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia
Creators: name: Owen, M.J
name: Mulliken, J.B
name: Otto, F
name: Mundlos, S
name: Mundlos, C
name: Lindhout, D
name: Olsen, B.R
name: Mertelsmann, R
name: Henn, W
name: Cole, W.G
name: Albright, S
name: Aylsworth, A.S
name: Knoll, J.H.M
name: Zabel, B.U
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: AbstractCleidocranial dysplasia (CCD) is an autosomal-dominant condition characterized by hypoplasia/aplasia of clavicles, patent fontanelles, supernumerary teeth, short stature, and other changes in skeletal patterning and growth. In some families, the phenotype segregates with deletions resulting in heterozygous loss of CBFA1, a member of the runt family of transcription factors. In other families, insertion, deletion, and missense mutations lead to translational stop codons in the DNA binding domain or in the C-terminal transactivating region. In-frame expansion of a polyalanine stretch segregates in an affected family with brachydactyly and minor clinical findings of CCD. We conclude that CBFA1 mutations cause CCD and that heterozygous loss of function is sufficient to produce the disorder.
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
Creators: name: Xiong, Yue
name: Yarbrough, Wendell G
name: Zhang, Yanping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: AbstractThe INK4a-ARF locus encodes two unrelated proteins that both function in tumor suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF arrests the cell cycle in a p53-dependent manner. We show here that ARF binds to MDM2 and promotes the rapid degradation of MDM2. This interaction is mediated by the exon 1β–encoded N-terminal domain of ARF and a C-terminal region of MDM2. ARF-promoted MDM2 degradation is associated with MDM2 modification and concurrent p53 stabilization and accumulation. The functional consequence of ARF-regulated p53 levels via MDM2 proteolysis is evidenced by the ability of ectopically expressed ARF to restore a p53-imposed G1 cell cycle arrest that is otherwise abrogated by MDM2. Thus, deletion of the ARF-INK4a locus simultaneously impairs both the INK4a–cyclin D/CDK4-RB and the ARF-MDM2-p53 pathways.
Online adaptive basis refinement and compression for reduced-order models via vector-space sieving
Creators: name: Etter, Philip A.
name: Carlberg, Kevin T.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In many applications, projection-based reduced-order models (ROMs) have demonstrated the ability to provide rapid approximate solutions to high-fidelity full-order models (FOMs). However, there is no a priori assurance that these approximate solutions are accurate; their accuracy depends on the ability of the low-dimensional trial basis to represent the FOM solution. As a result, ROMs can generate inaccurate approximate solutions, e.g., when the FOM solution at the online prediction point is not well represented by training data used to construct the trial basis. To address this fundamental deficiency of standard model-reduction approaches, this work proposes a novel online-adaptive mechanism for efficiently enriching the trial basis in a manner that ensures convergence of the ROM to the FOM, yet does not incur any FOM solves. The mechanism is based on the previously proposed adaptive $h$-refinement method for ROMs [12], but improves upon this work in two crucial ways. First, the proposed method enables basis refinement with respect to any orthogonal basis (not just the Kronecker basis), thereby generalizing the refinement mechanism and enabling it to be tailored to the physics characterizing the problem at hand. Second, the proposed method provides a fast online algorithm for periodically compressing the enriched basis via an efficient proper orthogonal decomposition (POD) method, which does not incur any operations that scale with the FOM dimension. These two features allow the proposed method to serve as (1) a failsafe mechanism for ROMs, as the method enables the ROM to satisfy any prescribed error tolerance online (even in the case of inadequate training), and (2) an efficient online basis-adaptation mechanism, as the combination of basis enrichment and compression enables the basis to adapt online while controlling its dimension.
Fermi Surface and gap parameter in high-Tc superconductors: the Stripe Quantum Critical Point scenario
Creators: name: Caprara, S.
name: Di Castro, C.
name: Grilli, M.
name: Perali, A.
name: Sulpizi, M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the single-particle spectral properties of electrons coupled to quasicritical charge and spin fluctuations close to a stripe-phase, which is governed by a Quantum Critical Point near optimum doping. We find that spectral weight is transferred from the quasiparticle peak to incoherent dispersive features. As a consequence the distribution of low-laying spectral weight is modified with respect to the quasiparticle Fermi surface. The interplay of charge and spin fluctuations reproduces features of the observed Fermi surface, such as the asymmetric suppression of spectral weight near the M points of the Brillouin zone. Within the model, we also analyze the interplay between repulsive spin and attractive charge fluctuations in determining the symmetry and the peculiar momentum dependence of the superconducting gap parameter. When both spin and charge fluctuations are coupled to the electrons, we find $d_{x^2-y^2}$-wave gap symmetry in a wide range of parameter. A crossover $d$- vs $s$-wave symmetry of the gap may occur when the strength of charge fluctuations increases with respect to spin fluctuations.
description: 18 pages, 3 included figures, to be published on Physica C
Eukaryotic Fatty Acylation Drives Plasma Membrane Targeting and Enhances Function of Several Type III Effector Proteins from Pseudomonas syringae
Creators: name: Katagiri, Fumiaki
name: Leister, R.Todd
name: Marois, Eric
name: Kjemtrup, Susanne
name: Dangl, Jeffery L
name: Nimchuk, Zachary
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: AbstractBacterial pathogens of plants and animals utilize conserved type III delivery systems to traffic effector proteins into host cells. Plant innate immune systems evolved disease resistance (R) genes to recognize some type III effectors, termed avirulence (Avr) proteins. On disease-susceptible (r) plants, Avr proteins can contribute to pathogen virulence. We demonstrate that several type III effectors from Pseudomonas syringae are targeted to the host plasma membrane and that efficient membrane association enhances function. Efficient localization of three Avr proteins requires consensus myristoylation sites, and Avr proteins can be myristoylated inside the host cell. These prokaryotic type III effectors thus utilize a eukaryote-specific posttranslational modification to access the subcellular compartment where they function.