cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Environmental Causes of Breast Cancer Across Generations
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This study will test the idea that prenatal exposure to environmental chemicals increases the risk of breast cancer. Many of these compounds are known to affect fertility, birth outcomes and immune function and are thus suspected causes of or contributors to breast cancer. However, no human study has been able to measure exposure in the womb, a time of vulnerability for the developing fetus.

 This project will focus on polycholorinated biphenyls (PCBs) and the chemical that it breaks down into in the body, which is known to increase estrogen action and to cross over to the fetus more readily than the original PCB compounds. Investigators will also further examine the insecticide DDT, which they previously linked to increased breast cancer risk.

 This project will follow-up on the Child Health and Development Studies cohort, a group of women who gave birth in the Bay Area between 1959 and 1967. Daughters of these women will be surveyed to identify their risk factors and environmental exposures. Blood samples from when their mothers were pregnant will be tested for the suspect chemicals to look for differences between those women with a breast cancer diagnosis and those without in their 40s, and between women of different race/ethnicity, education and geographic areas.

 CHDS granddaughters, who are now in young childhood and adolescence, when contemporary exposures to environmental chemicals can be captured at a vulnerable period of breast development, will also be invited to participate with their mothers.

 This project will also establish procedures for ongoing participant involvement in this project as the daughters and the granddaughters move through the ages of breast cancer risk. An Advisory Committee consisting of cohort members will help design study procedures, materials, review research objectives and disseminate findings.

 This project will result in a wholly unique three-generation study of the environmental causes of breast cancer and will describe disparities in these exposures based on multiple available classifications of social educational and geographic characteristics in addition to race/ethnicity. This project is the first “womb to breast cancer study”. Because prior research strongly implicates early life exposures as important, we expect to make a significant contribution to understanding preventable, environmental causes of breast cancer.
Anti-metastatic properties of a polyamide HIF antagonist
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The capacity of malignant cells for invasion and metastasis is triggered in part by the metabolic needs of the growing tumor. As the cancer grows, its demand for nutrients and oxygen overwhelms the local blood supply. A low oxygen level, or hypoxia, causes the cell to increase the amount of a DNA-binding protein, called hypoxia inducible factor (HIF). In addition to activating genes involved in blood vessel formation, recent studies in breast cancer cells have shown that HIF also induces the expression or tumor cell genes directly implicated in invasion and metastasis. These genes, which include lysyl oxidase and endothelins, allow the cell to detach from its neighbors and digest a path through the extracellular matrix. This new data strongly implicates HIF in the transition a breast tumor makes from a benign lesion to malignant disease.

 In this project, we have chosen to target HIF using polyamides, a class of synthetic, sequence-specific DNA-binding molecules that can block the transcription factor-DNA interaction. Towards this goal, we have designed a polyamide to recognize the same DNA sequence as HIF to block the protein from binding to its target site. By interfering with HIF binding in this fashion, we can inhibit the expression of some HIF-target genes in cell culture. Preliminary results from the breast cancer cell line MCF-7 indicate that endothelin expression may indeed be inhibited by polyamide treatment. Our approach is to induce hypoxia and compare gene expression levels between treated and untreated cells to establish activity of the polyamide inhibitor of HIF. As a control we will use RNAi vs. HIF, a well-established anti-gene methodology. The results of the gene expression studies will be confirmed using protein-based assays as well as chromatin immunoprecipitation (ChIP), which can confirm reduced binding of HIF to its target site when the polyamide is present. Finally, we will measure the ability of the polyamide inhibitors to block cell migration.

 DNA-binding drugs have been part of cancer therapy for years. Most of these drugs damage DNA in a non-selective manner, killing cancerous cells and healthy cells alike. Many of the negative sequelae associated with chemotherapy, including anemia, treatment-related leukemia and infertility, are direct consequences of non-specific genomic insult. Polyamides, on the other hand, are designed to control cancer-causing genes without DNA damage. Therefore, in addition to providing a new way to control the spread of breast cancer, we hope that a polyamide-based, non-cytotoxic breast cancer drug would also help patients avoid the pain and suffering associated with conventional chemotherapy.
Additional file 1: Table S1. of The peptidylglycine-Îą-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population
Creators: name: Yoo, Hye
name: Minjoo Kim
name: Minkyung Kim
name: Jey Chae
name: Sang-Hyun Lee
name: Lee, Jong
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Characteristics of the Korean chip. Table S2. Top ten SNPs associated with systolic and diastolic BP. Table S3. Frequencies of the PAM rs13175330 A>G SNP genotypes in the normotensive controls and HTN group based on antihypertensive therapy. Table S4. PAM gene function. (DOCX 22Â kb)
Goniobranchus tinctorius
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus tinctorius

description: Goniobranchus cf. tinctorius (Rüppell & Leuckart, 1830)
(Figures 7 E–F)
Material examined. Four specimens. MB28-004870, VAR, 23 May 2014, 3m, 62mm, collected at night; MB28- 0 0 4872, VAR, 23 May 2014, 3m, 84mm, collected at night; ZMBN94194, 2 spcs., VAR, 28 Jan. 2014, 4m, 50mm and 70mm.
Habitats. Artificial reef on seagrass bank in the transitional zone between the tropics and subtropics. Occurences. Vilanculos.
Geographic distribution. Indian Ocean. Oman (Gosliner et al. 2008), India (Remakrishna et al. 2010), Red Sea, South Africa (Gosliner 1987) and Mozambique.
Remarks. There was a slight colour variation between the specimens mainly on the submarginal region of the mantle. The specimen MB28-004870 has a submarginal band formed by pinkish oval markings with white spots (Fig. 7 E); whereas, in specimen MB28-004872 the submarginal band lacks oval markings (Fig. 7 F). Both specimens were found together, therefore the difference is likely to be simply intraspecific variation. This species matches most of the original description of Goniobranchus tinctorius (Rüppel & Leuckart 1828), except by the dorsal part of the foot; which in the specimens from Mozambique is white with a purple-white edge, but in original description shows irregular colour with red spots. Our specimens, as with many of the red reticulate Goniobranchus, belong to a potential Goniobranchus tinctorius complex, which is in need of further studies (Gosliner et al. 2008, 2015).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 30-31, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Coleoxestia apeara Galileo & Santos-Silva 2016
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Coleoxestia
Coleoxestia apeara

description: 2. Coleoxestia apeara Galileo & Santos-Silva, 2016b: 126, figs. 1 – 4 Holotype, male
Type locality. Brazil, Distrito Federal: Brasília (Fazenda Água Limpa, Universidade de Brasília, 1050 m, 15°56'49"S / 47°56'15"W), 25.III.2008, J.A. Rafael & F.F. Xavier Filho
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 348, DOI: 10.5281/zenodo.250291
Assembly of natural photosynthetic components on graphene oxide and gold surfaces for light energy transduction
Creators: name: Harrold Jr., John W.
Publisher: name: No Publisher Supplied
Year: 2014

description: Photosynthetic reaction centers are integral membrane proteins of particular interest for their remarkable ability to catalyze photo-induced charge separation with high quantum efficiency. For this reason they have been targeted for integration in biohybrid systems for capture and conversion of solar energy. In this study isolated photosynthetic core complexes from phototrophic organisms are interfaced with conductive materials for the development of photoelectrochemical systems. Photosystem II core complexes (PSII CCs) bearing poly histidine tags isolated from genetically modified Thermosynechococcus elongatus, were tethered to a graphene oxide (GO) support through immobilized metal coordination sites. The PSII CCs tethered to GO-coated gold electrodes and GO nanosheets in suspension showed 59% retention of quantum yield of photochemistry. Fluorescence kinetic relaxation analyses indicates that a direct electron transfer occurs between embedded quinone (QA) of PSII and GO. Flash oxygen evolution activity shows a threefold improvement in comparison with isolate PSII in suspension. Photosystem I core complexes (PSI CCs) isolated from Synnehcoccous PCC &002 was also immobilized on GO. The co-immobilization of PSII and PSI on GO resulted in a biohybrid electron transport chain on the model of the photosynthetic Z-scheme. As a robust alternative to PSII, a very labile enzyme, chromatophores isolated from the bacterium Rhodospirillum rubrum were adsorbed on gold electrodes. These intracytoplasmic membrane vesicles containing bacterial type II reaction centers yielded a maximum photo-driven current of 1.5 μA/cm2 that slowly declined in a week. This study demonstrates the utility of bottom-up reconstruction of biological nanostructure as a platform for fundamental experimental approaches and the pursuit of new paradigms toward renewable energy resources.
Characterization of the novel h82r mutation in cgi-58 that causes neutral lipid storage disorder in humans
Creators: name: Hassanien, Sarah
Publisher: name: No Publisher Supplied
Year: 2014

description: Comparative gene identification-58 (CGI-58) interacts with and co-activates adipose triglyceride lipase (ATGL). The H82R mutation in human CGI-58 causes a neutral lipid storage disorder (NLSD) characterized by ichthyosis and excessive triacylglycerol storage in many types of cells. We studied the comparable H84R mutation in mouse CGI-58, and H84A mutated CGI-58, to ask how CGI-58 function is impaired. The ectopic expression of wild-type (WT) CGI-58 in human NLSD fibroblasts reduced excessive triglyceride storage to normal levels, whereas H84R CGI-58 was ineffective. Additionally, H84R CGI-58 failed to co-activate ATGL in an in vitro triglyceride hydrolase assay and H84A CGI-58 was not as efficient, when compared to WT CGI-58. Immunofluorescence microscopy revealed that H84R and H84A CGI-58 localized to ectopic perilipin 1A on lipid droplets of cultured NIH3T3CARΔ fibroblasts as well as WT CGI-58. Moreover, the addition of forskolin and isobutylmethylxanthine to the cells triggered the dispersion of all three variants of CGI-58 from the perilipin scaffold into the cytoplasm. A co-immunoprecipitation assay demonstrated that H84R and H84A CGI-58 bound ATGL as well as WT CGI-58. Additionally, while WT CGI-58 and ATGL can be individually recruited to lipid droplets and ATGL recruitment to lipid droplets is increased in the presence of CGI-58, the H84R and H82R mutations do not interfere with lipid droplet recruitment of CGI-58 with ATGL. Thus, although H84R CGI-58 shows appropriate subcellular localization in cells expressing perilipin 1A, binds to ATGL, and is effectively recruited to lipid droplets, it does not co-activate ATGL’s hydrolase activity. Future experiments are needed to explore additional mechanisms for deficient function of H84R CGI-58.
Cnestus mutilatus
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Cnestus
Cnestus mutilatus

description: Cnestus mutilatus (Blandford, 1894)
МатериаΛ: 2 экз.: 07.2022.
Новый эΛемент фауны Приморья, распространяющийся к северу, так как в монографиях Куренцова (1941) и КривоΛуцкой (1996) этот виΑ еще отсутствует. Раньее в Приморском крае быΛ найΑен тоΛько в Партизанском районе (МанΑеΛьштам и Αр. 2018). В Приморье на грабе Carpinus cordata.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Anisandrus maiche
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Anisandrus
Anisandrus maiche

description: Anisandrus maiche (Kurentsov, 1941)
МатериаΛ: 6 экз.: 12.06.2022; 9 экз.: 18.06.2022; 120 экз.: 07.2022; 15 экз.: 14.08.2022, И. Δ. СоΛоΑкий; 5 экз.: 18.08.2022, И. Δ. СоΛоΑкий.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Goniobranchus verrieri
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus verrieri

description: Goniobranchus verrieri (Crosse, 1875)
(Figures 7 G, 8 A–D)
Material examined. Two specimens. MB28-004596, ZJS, 23 Jun. 2012, 8m, 8mm; MB28-004657, ZWH, 17 Mar. 2013, 19m, 15mm.
Habitats. Subtropical rocky reefs.
Occurrences. Zavora.
Geographic distribution. Indo-west, central Pacific. Hawaii, Philippines, Papua New Guinea, Indonesia (Gosliner et al. 2008), Marshal Islands, New Caledonia, Tanzania (Rudman 1985), South Africa, Madagascar (Gosliner et al. 2008) and Mozambique.
Remarks. This species is externally similar to Verconia subnivalis Baba, 1987 from Japan. Thus, the confirmation of its identity was done through examination of the radula in optical microscope. The radula formula of the specimen MB28-004657 was 40X 34.0.34 (+2). The radula matches the description of Goniobranchus verrieri provided by Rudman (1985) and it clearly differs from Verconia subnivalis by a distinctive central tickeness, which is absent in V. subnivalis (Baba 1987a).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 31-32, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Novel Cell-matrix Markers and Drivers of Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A critical determinant of breast cancer progression is the genesis of abnormal interactions between the cancer cells and their microenvironment. Influencial components of the normal and cancer microenvironment are extracellular matrix (ECM) molecules. Receptors for ECM molecules undergo changes in expression in breast cancers, and these alterations are associated with disease progression. Thus, novel therapies that target ECM receptors would have broad utility.

 My laboratory has recently identified the presence of a novel ECM receptor on the surface of breast cancer cells, called Lutheran or BCAM. It appears to bind with high affinity to the laminin α5 subunit, a component of the ECM. The α5 laminins are virtually uniform elements of the breast tumor microenvironment; therefore, aberrant adhesive interactions between BCAM and α5 laminins can potentially drive breast cancer progression at multiple stages. Recently, we have established that elevated BCAM expression arises frequently in human breast cancers, including both invasive breast cancers and a subset of ductal carcinoma in situ (DCIS).

 To further study the consequence of elevated BCAM expression on cell behavior, in this project we will manipulate BCAM expression in normal and cancerous breast epithelial cells and measure the resulting changes in cell function using both in cell-based and animal-model assays. The cell-based assays will employ 3D assays of growth, morphogenesis, and invasion within “gels” of reconstituted ECM/basement membrane proteins. Animal work will employ xenograft (mouse model) assays of human breast cancer growth and metastasis in the presence and absence of elevated BCAM expression. In addition, a genetically engineered mouse model is being generated to produce elevated BCAM expression in the normal mouse mammary epithelium, and will be analyzed for disruption of normal mammary tissue morphogenesis and homeostasis. Finally, we will determine whether BCAM can act as a biomarker of breast cancer progression.
Reducing Surgical Morbidity of Breast Cancer Staging
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Underarm lymph nodes are commonly removed to determine how far breast cancer has spread. Swelling of the arm after (lymphedema) is a common (up to 77% of patients) complication of this operation and can lead to loss of function, pain, or disfigurement. This is due to the loss of lymphatic channels draining the arm that are damaged or removed during removal of lymphatics draining the breast. Any decrease in this complication either in rate or severity could dramatically improve patients’ quality of life.

 This project is a continuation of a previous IDEA grant from CBCRP and involves “mapping” the lymphatic drainage of the arm will allow us to spare them when removing breast draining lymphatics to stage breast cancer. We call this approach axillary reverse mapping (ARM). The surgical procedure is accomplished by injecting a blue dye into the arm at the time breast draining lymphatics are removed. During the pilot phase of our clinical trial, the mapping will occur, but patients will receive the standard operation in order to best determine the number of patients who can benefit and estimate the risk of potentially failing to remove cancer containing lymph nodes. After this phase, future patients will be randomized to either receive the blue dye injection prior to the operation with the surgeon attempting to save all arm related lymphatics, or after a standard operation. Comparisons of these two groups using both objective measurements and patient questionnaires will identify the usefulness of this procedure in reducing complications. Our research includes the City of Hope National Medical Center, the University of California Davis, and the University of North Carolina.

 Improvements in the ability of surgeons to perform lower morbidity operations for breast cancer staging and locoregional control of breast cancer will have an impact in multiple ways. More women will be willing to undergo completion axillary dissection, potentially leading to improved staging of patients, improved cancer control for patients, and the potential ability to decrease the use of radiation to the axilla, with its attendant risks. Further understanding of the factors leading to lymphedema after axillary dissection, may lead to further improvements in surgical techniques that avoid this devastating complication.
Cryphalus redikorzevi Berger 1917
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Cryphalus
Cryphalus redikorzevi

description: Cryphalus redikorzevi Berger, 1917
МатериаΛ: 8 экз.: 20.08.2000, поΑ корой суков пихты цеΛьноΛистной Abies holophylla, Λежащих на земΛе, МЮМ; 6 экз.: 5.08.2021; 5 экз.: 13– 28.07.2021; 45 экз.: 10.05.2022, массовый Λет на свежих ветроваΛах, МЕС; 3 экз.: 11.05.2022; 1 экз.: 17.05.2022; 71 экз.: 28.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Additional file 3: Figure S4. of Chloroplast PetD protein: evidence for SRP/Alb3-dependent insertion into the thylakoid membrane
Creators: name: Jarosław Króliczewski
name: Rafał Bartoszewski
name: Bożena Króliczewska
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The Kyte–Doolittle hydropathy profile of the first 75 amino acids of pea PetD and ceQORH (Chloroplast Envelope Quinone Oxido-Reductase Homologue). (PDF 146 kb)
Victorian elegy in the age of photography
Creators: name: Hoffman, Jesse
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation argues that nineteenth-century elegiac literature and photography exist in a surprisingly close, interconstitutive relationship that enables elegy to continue to redress loss in a culture where the proliferation of images threatens to subsume the work of mourning. The project builds on important scholarship in the history of science and technology in order to demonstrate the troubled role of elegy’s fascination with visual media in the nineteenth century. I identify a pervasive ambivalence about how to visualize the deceased that shapes major elegies by Alfred Tennyson, Dante Gabriel Rossetti, and Thomas Hardy—works that both desire and resist the photographic technologies they imagine. In Tennyson’s In Memoriam, for example, the poet evokes a medium that will allow him to see Hallam, but he disavows the images themselves as inadequate consolations. Furthermore, I argue that Tennyson’s great poems of light and loss, “Tithon” and “Tithonus,” are concerned with the same paradox of visualizing absence that the scientist John William Draper describes as “tithonicity,” which he defines as the imponderable force responsible for the creation and destruction of photographs. In another poignant instance, Rossetti’s destruction of photographic portraits of his late wife, Elizabeth Siddal, reveals a fearful ambivalence about reproducibility instantiated textually in the elegiac sections of The House of Life. In the age of photography, elegy’s conventional aspiration to mourn and commemorate the dead is not only reshaped as a struggle to reconcile what remains with what cannot return, but the ambivalence towards the beloved’s residual image becomes increasingly acute in verses consumed with traces, outlines, and other signs of loss that the age of photography makes visible.  For this reason, I understand photography as a dynamic site—as much cultural as technical. Drawing on recent revisions to the history of photography’s origins in the nineteenth century, I offer an account of Victorian elegy’s vexed relationship with this technology as it develops between the anticipations of photography in Romanticism and the emergent motion pictures of early Modernism.
Hypselodoris bullockii
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Hypselodoris
Hypselodoris bullockii

description: Hypselodoris bullockii (Collingwood, 1881)
(Figures 7 H, 9 A–D)
Material examined. Six specimens. MB28-004828, 5 spcs., POA, 0 8 May 2014, 40m, 34mm; MHN-YT1671, NSS, 16 Feb. 2017, 25m, 49mm.
Habitats. Subtropical tidal reefs and tropical coral reefs.
Occurrences. Ponta do Ouro.
Geographic distribution. Indo-west, central Pacific. Marshall Islands, Japan, New Caledonia (Gosliner et al. 2008), Australia (Debelius 1996; Gosliner et al. 2008), Taiwan, Indonesia, the Philippines (Gosliner et al. 2008), Thailand (Mehrotra & Scott 2015), Christmas Island, Indonesia, Maldives (Debelius 1996) and Mozambique (King & Fraser 2014).
Remarks. Published details of the morphology of H. bullockii are relatively poor and in need of further study (Gosliner & Johnson 1999). Gosliner et al. (2015) consider H. bullockii to be restricted to the Pacific Ocean and note that records from the Indian Ocean refer to Thorunna punicea (Rudman, 1995). Thus, to confirm the generic placement of our material, we examined the radula of one specimen (MB28-004828, Fig. 9). Despite some external similarities between Thorunna and Hypselodoris, the radular teeth of these two genera are distinctive (Rudman 1990). The radula formula of the examined specimen was 57x 47.0.47 (Fig. 9 A). Central teeth are absent (Fig. 9 B), the innermost teeth bear two to three pointed denticles of different size on the inner and four on the outer sides (Fig. 9 C). The median lateral teeth bear 3-5 denticles including one that is bicuspid (Fig. 9 D). This confirms that this species belongs to the genus Hypselodoris. Nevertheless, additional studies are needed to verify the intraspecific variability of this species.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 32, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Post-decolonization secession
Creators: name: Hu, Pei-Ling
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation presents the phenomenon of post-decolonization secession and its literature as important new topic and genre for postcolonial studies. It draws on legal documents from international law, human rights law and UN doctrines to examine the paradox within the presumably inalienable, yet context-confined, right of peoples to self-determination. Although in UN’s 1960 Declaration on the Granting of Independence to Colonial Countries and Peoples, the first introduction of the right of self-determination in international law, it was set up to be the right of all peoples, it is only practiced as a binding, legal right in the context of decolonization. The UN-assisted decolonization process insists that self-determination happen along colonial borders, and newly independent postcolonial states inherit colonial territories. Postcolonial independence achieved in this manner retains the racial fault lines from the colonial era, which facilitates the reenactment of the dialectics of the settler and the native, hindering the development of a sense of national consciousness. This dissertation reads post-decolonization secession as delayed decolonization endeavor emerging out of strong (ethno)nationalist sentiment. It argues that post-decolonization secession lays bare the conditions and terms of the decolonization process, and of becoming/being postcolonial itself.  This study discusses four post-decolonization secession movements—Biafra/Nigeria, Gorkhaland/India, Tamil Eelam/Sri Lanka, and South Sudan/Sudan—alongside five secession literary texts: Chinua Achebe’s There Was a Country, Chimamanda Adichie’s Half of a Yellow Sun, Kiran Desai’s The Inheritance of Loss, Michael Ondaatje’s Anil’s Ghost and Dave Eggers’s What Is the What. It traces the evolution of the concept of the self-determination right after 1960 and the world’s changing response to these secession crises in postcolonial regions. The literature not only bears testimony to these shifts but also examines aspects of the situation that the political and legal processes cannot resolve. While politically and legally, secession aspiration is always conflated with state-building, secession literature reminds us that secession movements are first and foremost anti-state projects, especially in the post-decolonization context. Secession literature dwells on this anti-state sentiment and pre-state phase, and suggests “non-state nationalism” as an alternative mode of a people’s political being and a new type of sovereignty.
Cyclorhipidion pelliculosum
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Cyclorhipidion
Cyclorhipidion pelliculosum

description: Cyclorhipidion pelliculosum (Eichhoff, 1878)
МатериаΛ: 3 экз.: 11.05.2022; 3 экз.: 17.05.2022; 5 экз.: 22.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Coleoxestia moromokoi Galileo & Santos-Silva 2016
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Coleoxestia
Coleoxestia moromokoi

description: 3. Coleoxestia moromokoi Galileo & Santos-Silva, 2016b: 129, figs. 5 – 8 Holotype, male
Type locality. Brazil, Amazonas: Ipixuna (Rio Liberdade, Estirão da Preta, 07°21'46.7"S / 71°52'07.1"W), 11- 15.V.2011, J.A. Rafael, J.T. Câmara, R.F. Silva, A. Somavilla & C. Gonçalves
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 348, DOI: 10.5281/zenodo.250291
Risk factors and breast cancer survival in black/white women
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Eliminating racial disparities in cancer mortality by the year 2015 is an American Cancer Society challenge goal. To date, the disparity in breast cancer mortality between black women and white women is still increasing with black women having the highest mortality rates. The reasons for this racial disparity are not completely understood. Risk factors for breast cancer incidence may promote the development of specific types of breast cancer, and thus influence the course of disease and have an effect on survival. Although data on relationship between risk factors and breast cancer survival are increasing, few studies provide detailed information on multiple risk factors and few data on these relationships exist for black women.

 In this project, we will use the unique opportunity provided by the Women’s Contraceptive and Reproductive Experiences (CARE) Study to investigate the association between established breast cancer risk factors and their effect on all-cause mortality and breast cancer-specific mortality. We will also examine whether these risk factors explain at least, in part, the racial disparity in breast cancer survival between black women and white women. Our aims to determine whether breast cancer survival is affected by a woman’s:

 - family history of breast cancer

 -body size measures including height, weight, body mass index (kg/m2, BMI), and weight change before diagnosis

 -recreational physical activity before diagnosis

 -reproductive characteristics including age at menarche, parity, age at first full-term pregnancy, and time since most recent birth and breastfeeding

 -use of exogenous hormones (oral contraceptives and menopausal hormone therapy)

 For this study we will use participants in the Women’s CARE Study, which enrolled 2953 white and 1622 black invasive breast cancer patients aged 35 to 64 years, have been followed for survival since their diagnoses between 1994 and 1998. Since completing a detailed interview on breast cancer risk factors shortly after diagnosis, 1044 (511 black and 533 white) have died with 793 deaths (394 black and 399 white) attributed to breast cancer.

 Identifying lifestyle and other factors that modify the risk of mortality following breast cancer will enhance our ability to improve the survival experience of women diagnosed with breast cancer. It will help us predict whether specific subgroups have an increased risk of mortality. It will also provide leads to understanding the underlying biology mechanisms influencing prognosis, and thus will provide potential solutions for clinical decision for breast cancer patients.
Additional file 1: of Treatment recommendations within the leeway of clinical guidelines: A qualitative interview study on oncologistsâ   clinical deliberation
Creators: name: I. Otte
name: S. Salloch
name: A. Reinacher-Schick
name: J. Vollmann
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Interview guide (PDF): This file contains the set of interview questions which has been used for the semi-structured interview part of this study. (PDF 110Â kb)
A Novel Mediator of AI Resistance in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Seventy-five percent of postmenopausal and 60% of premenopausal women exhibit hormone responsive tumors such as the estrogen receptor (ER+) phenotype. Currently, FDA-approved third generation drugs called aromatase inhibitors (AIs), which inhibit catalysis of androgens into estrogen, are utilized for these ER+ phenotypic breast cancers. However, over the course of treatment, these endocrine responsive tumors, in many women, acquire resistance to treatments; hence, metastasis of breast cancer is inevitable. It has been reported that long term estrogen deprived treatments lead to continual tumor growth. This occurs via ER? molecular “crosstalk” with growth factor receptors and through activation of cell signaling pathways.

 This project aims to identify novel kinases/growth factors and the cell signaling pathways they activate. In previous work we identified a novel cell cycle protein, called cyclin-dependent kinase-7 (Cdk7), which has been reported to activate ER?. However, information about the molecular mechanisms and the role of Cdk7, specifically, in acquired AI-resistance is lacking. By elucidating Cdk7’s role in the pathogenesis of AI-resistant breast cancer cells, inhibition of metastasis and the development of novel drugs to overcome resistance will be possible.

 For these studies we specifically use endocrine-resistant cell line such as the long term estrogen-deprived cell line (LTEDaro), generated in our laboratory. This cell line serves as a model of late stage endocrine resistance because it does not respond to tamoxifen or any AIs. This cell line model is representative of cells prior to metastasis of disease.

 Our specific aims are to:

 1. Knockdown Cdk7 via RNA inhibition and by using inhibitor (Roscovitine) treatments to observe if AI-resistance is reversed.

 2. Determine if Cdk7 overexpression alone is sufficient to confer AI-resistance.

 3. Determine the molecular mechanisms by which Cdk7 affects AI-resistance. We will perform a microarray (gene profile) analysis on these cell lines to detect gene expression profile changes.

 Acquired resistance to endocrine therapy is inevitable for many hormone responsive tumors; hence, women who develop AI-resistant tumors have no other effective treatment for combating the disease. Knowledge of the mechanisms of acquired endocrine resistance will have a potential impact on the development of new anti-cancer drugs.
Relating diet and morphology of the head, mandibles and proventriculus in adult carabid beetles
Creators: name: Ingerson-Mahar, Joseph Michael
Publisher: name: No Publisher Supplied
Year: 2014

description: The Carabidae is a large family of beetles with 33,920 valid species world-wide.  While the specific diets of many of these species are known, especially among the Carabinae, the feeding preferences of the majority of species are unknown.  Attempts to determine the food preferences have been made relying upon morphological characters of the head and mouthparts but not in a quantitative manner.   A literature review of morphological characters of the Carabidae in 2002 showed that no consistent morphological character would predict the feeding preferences of all species.  In this study, twenty morphological measurements and character conditions from the adults of fourteen species of carabids representing five subfamilies and ten tribes were evaluated to determine whether there is a correlation between the morphology of the mandibles and proventriculus, the gut contents and field observations.  Using cluster analysis the measurement means and the presence or absence of structures of all twenty characteristics were evaluated.  Five characters were found to provide the most information and provided logical groupings.  However, it was apparent that predicting specific food preferences was not possible.  Instead the analysis indicated the type of feeding, that is, fluid feeding with extra-oral digestion, particulate feeding or mixed feeding incorporating both fluid feeding, and particulate feeding.     Fluid and mixed feeding species (Cicindela punctulata Oliver and Calosoma calidum F., Paraclivina bipustulata (F.)) were predaceous while particulate feeders (primarily carnivorous: Omophron labiatum F., Bembidion quadrimaculatum L., Poecilus chalcites (Say), Stenocrepis duodecimstriata Chevrolet, Lebia grandis Hentz, and Calathus gregarius Say; primarily herbivorous: Harpalus caliginosus F., Geopinus incrassatus Dej., Stenolophus lineola F., Zabrus tenebroides Goeze, and Anisodactylus laetus Dej.) could be both predaceous and herbivorous to varying degrees. Lack of field observations or conflicting evidence of other workers makes some of the designations questionable. Convergent evolution seemed a likely mechanism in unrelated groups in the development of the proventriculus.  Harpalus caliginosus demonstrated that although the members of the genus Harpalus are widely regarded to be seed eaters, H. caliginosus is at least a scavenger, if not predator, despite having mandibles appropriate for eating seeds.
Hylastes plumbeus Blandford 1894
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylastes
Hylastes plumbeus

description: Hylastes plumbeus Blandford, 1894
МатериаΛ: 3 экз.: 28.05.2022, оконные Λовушки, И. Δ. СоΛоΑкой.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Survival in de novo and recurrent metastatic breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is unclear whether newer chemotherapy agents have, in fact, improved overall patient survival overall. We have previously reported data from the City of Hope Comprehensive Cancer Center (COHCCC) registry which suggests that there is no improvement in survival for patients with metastatic breast cancer treated in two consecutive decades (between 1985 and 1994, or between 1995 and 2004). This finding was irrespective of the use of chemotherapy. Importantly, the patients considered in this analysis all had metastatic disease at the time of their original diagnosis of breast cancer.

 In this project we will expand our analysis to also include patients who have had localized breast cancer that has spread to distant sites (referred to as recurrent metastatic breast cancer). The key clinical questions we will address include:

 ~ For patients who have had a recurrence metastatic breast cancer, have advances in chemotherapy affected survival?

 ~ Is there a difference in survival amongst patients who have recurrent metastatic breast cancer, as compared to those patients who present initially with metastatic disease (i.e., the group of patients included in our original analysis)?

 For these studies we will obtain information regarding survival of patients with recurrent metastatic breast cancer treated with chemotherapy. We will divide these patients into two groups (patients diagnosed between 1985 and 1994, or between 1995 and 2004), and compare survival amongst these two groups. We will try to account for factors that may influence survival in these groups (for instance, the amount of time between the initial diagnosis of breast cancer and the diagnosis of metastatic disease). Finally, we will compare survival in the group analyzed in the previous study (patients who initially present with metastatic disease) and compare to survival in patients with recurrent metastatic breast cancer.

 Thus, this study may be the first to indicate differences in survival trends with chemotherapy in these two disease processes, and may ultimately lead to a change in the current therapeutic approach for both. Furthermore, these data may serve as the rationale for laboratory explorations of biological differences between de novo and recurrent MBC, perhaps yielding novel drug targets for both.
Additional file 4: Figure S5. of Chloroplast PetD protein: evidence for SRP/Alb3-dependent insertion into the thylakoid membrane
Creators: name: Jarosław Króliczewski
name: Rafał Bartoszewski
name: Bożena Króliczewska
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: MALDI-TOF mass spectra. (PDF 112 kb)
The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays
Creators: name: Inoyama, Daigo
Publisher: name: No Publisher Supplied
Year: 2014

description: Keap1-Nrf2 interaction is a key protein-protein interaction involved in the activation of antioxidant response element which regulates the expression of cytoprotective enzymes in response to oxidative stress conditions. To identify direct inhibitors of Keap1-Nrf2 interaction, a series of fluorescently-labeled Nrf2 peptides were synthesized and evaluated as tracers in the development of a fluorescence polarization (FP) assay. The optimized tracer, FITC-9mer Nrf2 amide, was determined to have the highest binding affinity and dynamic range of all tracers evaluated. The FP assay has considerable tolerance towards DMSO and was capable of distinguishing the inhibitory Nrf2 peptides with a Z'-factor of 0.&0 as determined under the FP assay conditions. Taken together, these results demonstrate that the FP assay is suitable for application in high-throughput screening (HTS).  In addition, a series of novel lanthanide chelates were designed, synthesized, and evaluated for the development of a time-resolved fluorescence resonance energy transfer (TR-FRET) assay using an in situ labeling approach. The cyclam and EDTA-based tris-NTA were found to have the strongest affinity to the His6-tag of Keap1 Kelch domain with a Kd of 1.6 nM and 2.2 nM, respectively. Among the tris-NTA conjugates evaluated as donors of TR-FRET, the EDTA-tris-NTA Acp6-linker conjugate was found to have the highest TR-FRET signal. The in situ labeling technique was also evaluated for Eu(III) chelate and through biotin-streptavidin interaction, increasing the choice of fluorophores and extending the application of the assay to biotinylated biomolecules. Thus, the novel labeling reagent provides an excellent solution for facile development of TR-FRET assays in drug discovery.  The FP assay was adapted for HTS of the NIH MLPCN library. Eight confirmed hits were obtained and one of the promising hits (LH602) was targeted for preliminary structure-activity relationship (SAR) studies. Among the synthesized compounds, 2,4,6-trimethylbenzenesulfonamide substituted analog 81 showed the highest affinity to Keap1 Kelch domain. However, LH602 was found to be unstable due to its naphthoquinone structure with a half-life of 6 hours in the assay buffer. Further SAR studies are needed to improve the binding affinity as well as stability of the compound in our effort to identify potent inhibitors of Keap1-Nrf2 interaction.