cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Matchings in Benjamini-Schramm convergent graph sequences
Creators: name: Abért, Miklos
name: Csikvári, Péter
name: Frenkel, Péter
name: Kun, Gábor
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C31, 05C70, 05C80, 05C30

description: We introduce the matching measure of a finite graph as the uniform distribution on the roots of the matching polynomial of the graph. We analyze the asymptotic behavior of the matching measure for graph sequences with bounded degree. A graph parameter is said to be estimable if it converges along every Benjamini-Schramm convergent sparse graph sequence. We prove that the normalized logarithm of the number of matchings is estimable. We also show that the analogous statement for perfect matchings already fails for d-regular bipartite graphs for any fixed d at least 3. The latter result relies on analyzing the probability that a randomly chosen perfect matching contains a particular edge. However, for any sequence of d-regular bipartite graphs converging to the d-regular tree, we prove that the normalized logarithm of the number of perfect matchings converges. This applies to random d-regular bipartite graphs. We show that the limit equals to the exponent in Schrijver's lower bound on the number of perfect matchings. Our analytic approach also yields a short proof for the Nguyen-Onak (also Elek--Lippner) theorem saying that the matching ratio is estimable. In fact, we prove the slightly stronger result that the independence ratio is estimable for claw-free graphs.
description: 21 pages. Changes compared to the previous (published) version: In Lemma 4.3, formula (4.3) and its proof have been corrected. As a consequence, the formula for the variance in Theorem 4.5 has been modified
How regiochemistry influences aggregation behavior and charge transport in conjugated organosulfur polymer cathodes for lithium-sulfur batteries
Creators: name: Schütze, Yannik
name: Gayen, Diptesh
name: Pałczynski, Karol
name: Oliveira Silva, Ranielle
name: Lu, Yan
name: Tovar, Michael
name: Partovi-Azar, Pouya
name: Bande, Annika
name: Dzubiella, Joachim
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: For lithium–sulfur (Li–S) batteries to become competitive, they require high stability and energy density. Organosulfur polymer-based cathodes have recently shown promising performance due to their ability to overcome common limitations of Li–S batteries, such as the insulating nature of sulfur. In this study, we use a multiscale modeling approach to explore the influence of the regiochemistry of a conjugated poly(4-(thiophene-3-yl)benzenethiol) (PTBT) polymer on its aggregation behavior and charge transport. Classical molecular dynamics simulations of the self-assembly of polymer chains with different regioregularity show that a head-to-tail/head-to-tail regularity can form a well-ordered crystalline phase of planar chains allowing for fast charge transport. Our X-ray diffraction measurements, in conjunction with our predicted crystal structure, confirm the presence of crystalline phases in the electropolymerized PTBT polymer. We quantitatively describe the charge transport in the crystalline phase in a band-like regime. Our results give detailed insights into the interplay between microstructural and electrical properties of conjugated polymer cathode materials, highlighting the effect of polymer chain regioregularity on its charge transport properties.
Between Merleau-Ponty and Ricoeur
Creators: name: Busacchi, Vinicio
Publisher: name: Critical Hermeneutics
Year: 2023

description: This paper aims to explore some aspects of Merleau-Ponty’s Phenomenology of perception (1945), proceeding from the chapter on attention – introductory section – to evaluate its redefining outcome, and to place it in dialectic with Paul Ricoeur’s research on Freedom and Nature (1950) – first section, chap. III. The hypothesis is that this work can help to shed new light both on a possible understanding of attention in the phenomenological perspective and that it can contribute to determine better the relationship between attention and the dimension of the involuntary. In the background, this opens up the dilemma about the possibility that a phenomenological approach to the unconscious could be a better explanation than a naturalising approach.
description: Critical Hermeneutics, V. 7 N. 1 (2023): On Attention: Between Philosophy and Psychoanalysis
Johannes Reuchlin, Briefwechsel, Bd. 1
Creators: name: Feld, Helmut
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 20 (2001): Rottenburger Jahrbuch für Kirchengeschichte, Band 20
Asymptotics of the Extremal Excedance Set Statistic
Creators: name: de Andrade, Rodrigo Ferraz
name: Lundberg, Erik
name: Nagle, Brendan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A16, 05A15

description: Answering a question of Clark and Ehrenborg (2010), we determine asymptotics for the number of permutations of size n that admit the most common excedance set. In fact, we provide a more general bivariate asymptotic using the multivariate asymptotic methods of R. Pemantle and M. C. Wilson. We also consider two applications of our main result. First, we determine asymptotics on the number of permutations of size n which simultaneously avoid the generalized patterns 21-34 and 34-21. Second, we determine asymptotics on the number of n-cycles that admit no stretching pairs.
description: 13 pages, 1 figure. Now published in the European Journal of Combinatorics
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.
Creators: name: Tejedor, Andres R
name: Sanchez-Burgos, Ignacio
name: Estevez-Espinosa, Maria
name: Garaizar, Adiran
name: Collepardo-Guevara, Rosana
name: Ramirez, Jorge
name: Espinosa, Jorge R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/57/2269
/631/57/2266
/631/114/2397
article

description: Funder: Ernest Oppenheimer Memorial Trust (Oppenheimer Memorial Trust); doi: https://doi.org/10.13039/501100009978
description: Biomolecular condensates, some of which are liquid-like during health, can age over time becoming gel-like pathological systems. One potential source of loss of liquid-like properties during ageing of RNA-binding protein condensates is the progressive formation of inter-protein β-sheets. To bridge microscopic understanding between accumulation of inter-protein β-sheets over time and the modulation of FUS and hnRNPA1 condensate viscoelasticity, we develop a multiscale simulation approach. Our method integrates atomistic simulations with sequence-dependent coarse-grained modelling of condensates that exhibit accumulation of inter-protein β-sheets over time. We reveal that inter-protein β-sheets notably increase condensate viscosity but does not transform the phase diagrams. Strikingly, the network of molecular connections within condensates is drastically altered, culminating in gelation when the network of strong β-sheets fully percolates. However, high concentrations of RNA decelerate the emergence of inter-protein β-sheets. Our study uncovers molecular and kinetic factors explaining how the accumulation of inter-protein β-sheets can trigger liquid-to-solid transitions in condensates, and suggests a potential mechanism to slow such transitions down.
On the Sensitivity of the Lasso to the Number of Predictor Variables
Creators: name: Flynn, Cheryl J.
name: Hurvich, Clifford M.
name: Simonoff, Jeffrey S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: The Lasso is a computationally efficient regression regularization procedure that can produce sparse estimators when the number of predictors (p) is large. Oracle inequalities provide probability loss bounds for the Lasso estimator at a deterministic choice of the regularization parameter. These bounds tend to zero if p is appropriately controlled, and are thus commonly cited as theoretical justification for the Lasso and its ability to handle high-dimensional settings. Unfortunately, in practice the regularization parameter is not selected to be a deterministic quantity, but is instead chosen using a random, data-dependent procedure. To address this shortcoming of previous theoretical work, we study the loss of the Lasso estimator when tuned optimally for prediction. Assuming orthonormal predictors and a sparse true model, we prove that the probability that the best possible predictive performance of the Lasso deteriorates as p increases is positive and can be arbitrarily close to one given a sufficiently high signal to noise ratio and sufficiently large p. We further demonstrate empirically that the amount of deterioration in performance can be far worse than the oracle inequalities suggest and provide a real data example where deterioration is observed.
Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression.
Creators: name: Talishinsky, Aleksandr
name: Downar, Jonathan
name: Vértes, Petra E
name: Seidlitz, Jakob
name: Dunlop, Katharine
name: Lynch, Charles J
name: Whalley, Heather
name: McIntosh, Andrew
name: Vila-Rodriguez, Fidel
name: Daskalakis, Zafiris J
name: Blumberger, Daniel M
name: Liston, Conor
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/378/1689/1414
/692/699/476/1414
/59/36
/45
/45/23
/45/91
article

description: The neural substrates of depression may differ in men and women, but the underlying mechanisms are incompletely understood. Here, we show that depression is associated with sex-specific patterns of abnormal functional connectivity in the default mode network and in five regions of interest with sexually dimorphic transcriptional effects. Regional differences in gene expression in two independent datasets explained the neuroanatomical distribution of abnormal connectivity. These gene sets varied by sex and were strongly enriched for genes implicated in depression, synapse function, immune signaling, and neurodevelopment. In an independent sample, we confirmed the prediction that individual differences in default mode network connectivity are explained by inferred brain expression levels for six depression-related genes, including PCDH8, a brain-specific protocadherin integral membrane protein implicated in activity-related synaptic reorganization. Together, our results delineate both shared and sex-specific changes in the organization of depression-related functional networks, with implications for biomarker development and fMRI-guided therapeutic neuromodulation.
Matthias Kaup, De prophetia ignota
Creators: name: Gerwing, Manfred
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 20 (2001): Rottenburger Jahrbuch für Kirchengeschichte, Band 20
Strong supermartingales and limits of nonnegative martingales
Creators: name: Czichowsky, Christoph
name: Schachermayer, Walter
Publisher: name: arXiv
Year: 2013
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Given a sequence $(M^n)^{\infty}_{n=1}$ of nonnegative martingales starting at $M^n_0=1$, we find a sequence of convex combinations $(\widetilde{M}^n)^{\infty}_{n=1}$ and a limiting process $X$ such that $(\widetilde{M}^n_τ)^{\infty}_{n=1}$ converges in probability to $X_τ$, for all finite stopping times $τ$. The limiting process $X$ then is an optional strong supermartingale. A counterexample reveals that the convergence in probability cannot be replaced by almost sure convergence in this statement. We also give similar convergence results for sequences of optional strong supermartingales $(X^n)^{\infty}_{n=1}$, their left limits $(X^n_-)^{\infty}_{n=1}$ and their stochastic integrals $(\intφ\,dX^n)^{\infty}_{n=1}$ and explain the relation to the notion of the Fatou limit.
description: Published at http://dx.doi.org/10.1214/14-AOP970 in the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Directional dependence of the local estimation of $H_0$ and the non perturbative effects of primordial curvature perturbations
Creators: name: Romano, Antonio Enea
name: Vallejo, Sergio Andrés
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recent measurements of the cosmic microwave background (CMB) radiation have shown an apparent tension with the present value of the Hubble parameter inferred from local observations of supernovae, which look closer, i.e. brighter, than what is expected in a homogeneous model with a value of $H_0$ equal to the one estimated from CMB observations. We examine the possibility that such a discrepancy is the consequence of the presence of a local inhomogeneity seeded by primordial curvature perturbations, finding that a negative peak of the order of less than two standard deviations could allow to fit low red-shift supernovae observations without the need of using a value of the Hubble parameter different from $H_0^{CMB}$. The type of inhomogeneity we consider does not modify the distance to the last scattering, making it compatible with the constraints of the PLANCK mission data. Our calculation is fully relativistic and non perturbative, and for this reason shows important effects which were missed in the previous investigations using relativistic perturbations or Newtonian approximations, because the structures seeded by primordial curvature perturbations can be today highly non linear, and relativist Doppler terms cannot be neglected. Comparison with studies of local structure based on galaxy surveys and luminosity density analysis reveals that the density profile we find could in fact be compatible with the one obtained for the same region of sky where is located most of the Cepheids used to calibrate the luminosity distance of the supernovae employed for the local $H_0$ estimation, suggesting a possible directional dependence and calibration bias which could be partially attributed to the presence of the Sloan Great Wall.
description: New updated references have been added. Some more information has been included about the region of sky in which the density profile predicted by our model is in agreement with luminosity density and galaxy surveys observations. Our model predicts the consequent overall supernovae luminosity distance calibration bias effect due to the presence in that region of the Cepheids
Can short PROMs support valid factor-based sub-scores? Example of COMQ-12 in chronic otitis media.
Creators: name: Bukurov, Bojana
name: Haggard, Mark
name: Spencer, Helen
name: Arsovic, Nenad
name: Sipetic Grujicic, Sandra
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: subject: Research Article
subject: Biology and life sciences
subject: Medicine and health sciences
subject: Social sciences
subject: FOS: Social sciences

description: PURPOSE: Interpretable factor solutions for questionnaire instruments are typically taken as justification for use of factor-based sub-scores. They can indeed articulate content and construct validities of a total and components but do not guarantee criterion validity for clinical application. Our previous documentation of basic psychometric characteristics for a 12-item patient-reported outcome measure in adult chronic otitis media (COMQ-12) justified next appraising criterion validity of sub-scores. METHODS: On 246 cases at 1st clinic visit, we compared various classes of factor solution, concentrating on the best-fitting 3-factor ones as widely supported. Clinical data offered two independent measures as external criteria: binaural hearing (audiometric thresholds measured via audiometry) for evaluating 'Hearing' sub-score, and oto-microscopic findings for the 'Ear discharge symptoms' sub-score. As criterion for the total, and for semi-generic 'Activities/healthcare' sub-score, the generic Short Form-36 item set offered a widely used multi-item criterion measure. RESULTS: Factor model fit and parsimony again favoured a 3-factor solution for COMQ-12; however insufficient item support and the dominant 1st principal component of variation made sub-scoring problematic. The best solution was bi-factor, from which only the weighted total score met the declared convergent validity standard of r = 0.50. Two of the more specific sub-scores ('Ear discharge symptoms' and 'Hearing') correlated poorly with clinical findings and weighted binaural hearing thresholds. CONCLUSION: The COMQ-12 total is acceptably content-valid for general clinical purposes, but the small item set, reflecting excessive pressure for brevity in clinical application, does not well support three criterion-valid factor-based scores. This distinction should be made explicit, and profile sub-scoring discouraged until good convergent and furthermore divergent criterion validities are shown.
Coordinated expression of the genes encoding FocA and pyruvate formate-lyase is important for maintenance of formate homeostasis during fermentative growth of Escherichia coli
Creators: name: Kammel, Michelle
name: Sawers, Robert Gary
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: FocA is a pentameric membrane channel that translocates formic acid bidirectionally across the cytoplasmic membrane of Escherichia coli during fermentation. The focA gene is co-transcribed with pflB, which encodes pyruvate formate-lyase, the enzyme that generates formate. Recent evidence has suggested that FocA serves to regulate intracellular formate levels and thus helps to maintain pH balance in fermenting cells. In this study, we aimed to provide support for this hypothesis by either altering FocA levels, mutating the chromosomal focA gene, or introducing additional copies of focA, either alone or with pflB, on a plasmid and monitoring the effect on intracellular and extracellular formate levels. Our results revealed that the expression of the native focA-pflB operon ensures that intracellular formate levels remain relatively constant during exponential phase growth, even when additional, mutated copies of focA that encode FocA variants are introduced in trans. Enhancing focA expression was balanced by higher formate excretion from the cell. Using chromosomal focA gene variants confirmed that FocA, and not PflB, sets intracellular formate homeostatic levels. Moreover, any chromosomal focA mutation that altered the formate concentration inside the cell caused a negative fermentative growth phenotype. Thus, FocA governs intracellular formate levels to ensure optimal growth during glucose fermentation.
Who Watches (and Shares) What on YouTube? And When? Using Twitter to Understand YouTube Viewership
Creators: name: Abisheva, Adiya
name: Garimella, Venkata Rama Kiran
name: Garcia, David
name: Weber, Ingmar
Publisher: name: arXiv
Year: 2013
Subjects: subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We combine user-centric Twitter data with video-centric YouTube data to analyze who watches and shares what on YouTube. Combination of two data sets, with 87k Twitter users, 5.6mln YouTube videos and 15mln video sharing events, allows rich analysis going beyond what could be obtained with either of the two data sets individually. For Twitter, we generate user features relating to activity, interests and demographics. For YouTube, we obtain video features for topic, popularity and polarization. These two feature sets are combined through sharing events for YouTube URLs on Twitter. This combination is done both in a user-, a video- and a sharing-event-centric manner. For the user-centric analysis, we show how Twitter user features correlate both with YouTube features and with sharing-related features. As two examples, we show urban users are quicker to share than rural users and for some notions of "influence" influential users on Twitter share videos with a higher number of views. For the video-centric analysis, we find a superlinear relation between initial Twitter shares and the final amounts of views, showing the correlated behavior of Twitter. On user impact, we find the total amount of followers of users that shared the video in the first week does not affect its final popularity. However, aggregated user retweet rates serve as a better predictor for YouTube video popularity. For the sharing-centric analysis, we reveal existence of correlated behavior concerning the time between video creation and sharing within certain timescales, showing the time onset for a coherent response, and the time limit after which collective responses are extremely unlikely. We show that response times depend on video category, revealing that Twitter sharing of a video is highly dependent on its content. To the best of our knowledge this is the first large-scale study combining YouTube and Twitter data.
description: 12 pages, 8 figures and 10 tables
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.
Creators: name: LaPierre, Mary P
name: Lawler, Katherine
name: Godbersen, Svenja
name: Farooqi, I Sadaf
name: Stoffel, Markus
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/692/699/2743/393
/631/443/319/367/1562
/631/337/384/331
/13
/13/1
/13/109
/13/106
/42/41
/42/44
/13/51
/64/60
/45/91
/45/77
/13/89
/123
/96/63
/82/80
article

description: Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272
description: Funder: Fondation Botnar; doi: https://doi.org/10.13039/501100011318
description: MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched miRNA in the hypothalamus, causes obesity in mice. Targeted deletion of miR-7 in Single-minded homolog 1 (Sim1) neurons, a critical component of the hypothalamic melanocortin pathway, causes hyperphagia, obesity and increased linear growth, mirroring Sim1 and Melanocortin-4 receptor (MC4R) haplo-insufficiency in mice and humans. We identified Snca (α-Synuclein) and Igsf8 (Immunoglobulin Superfamily Member 8) as miR-7 target genes that act in Sim1 neurons to regulate body weight and endocrine axes. In humans, MIR-7-1 is located in the last intron of HNRNPK, whose promoter drives the expression of both genes. Genetic variants at the HNRNPK locus that reduce its expression are associated with increased height and truncal fat mass. These findings demonstrate that miR-7 suppresses gene networks involved in the hypothalamic melanocortin pathway to regulate mammalian energy homeostasis.
First record of Erysiphe diffusa causing powdery mildew on Bergera koenigii in the USA
Creators: name: Moparthi, S.
name: Jailani, A. A. K.
name: Braun, Uwe
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 580

description: Bergera koenigii L., commonly known as the curry tree, belongs to the family Rutaceae (Singh et al., 2014). Its leaves are used as a spice for flavor in Indian cuisine and are a good source of vitamins and antioxidants (Rao et al., 2011). In March 2023, powdery mildew was observed on the young leaves of a potted B. koenigii plant in Raleigh, North Carolina (Fig. 1). The incidence of the disease on the plant was 30–40%; the mycelium mostly present on the adaxial surface. Hyphal appressoria were lobed, the foot cells of the conidiophores ranged from 23 to 60 μm in length. Hyaline conidia were formed singly, ellipsoid to cylindrical, without fibrosin bodies. The size of the conidia (n = 40) ranged from 14–38 × 11–18 μm, germ tubes were terminal. Mature chasmothecia were dark brown, globose, 92–100 μm in diameter, with most appendages unbranched, except one appendage with loosely dichotomously branched apex, tips of the ultimate branchlets straight. Each chasmothecium contained up to six asci that were broad ellipsoid-obovoid, with a short stalk. Each ascus contained four to six ellipsoid to ovoid amber-coloured ascospores (17-23 × 5–9 μm) (Fig. 2). Morphological features were consistent with the genus Erysiphe (Braun & Cook 2012). A few infected compound leaves were deposited in the herbarium at North Carolina State University (Catalog No. 000024426).
Die »Offenbarungen der Katharina Tucher«, hg. v. Ulla Williams u. Werner Williams-Krapp
Creators: name: Signori, Gabriela
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 20 (2001): Rottenburger Jahrbuch für Kirchengeschichte, Band 20
title: Vieillir au couvent, de l’habit au linge.
Fil de trame et fil de chaîne
title: Aging in convent, from the habit to laundry : weft and wrap.
Creators: name: Anchisi, Annick
Publisher: name: ethnographiques.org
Year: 2017
Subjects: Anthropologie
Ethnologie
Vieillissement
Vieillesse
congrégations, religieuses, habit religieux, linge, identité, vieillesse, soignantes
congregations, nuns, religious dress, laundry, identity, old age, dependency, caregivers

description: Les congrégations religieuses féminines vieillissent. Elles adoptent diverses stratégies pour faire face à ce phénomène, dont la transformation de parties de couvent en maisons de retraite médicalisées. Soutenu par des photos, l’accent est mis ici sur l’habit et le linge, indices de ce qui perdure autant que des impermanences. Signes d’une vie communautaire, porteurs de la mémoire et de l’intime, l’habit et le linge révèlent la vieillesse, la dépendance, le corps jusque-là davantage soustrait aux regards. Mais, malgré le grand âge et ses effets, l’habit religieux agit aussi comme marqueur d’une identité conservée. Son port rend compte d’une résistance aux injonctions de discipline du corps faites prioritairement aux femmes âgées. Témoin incorporé du temps qui passe, il permet également de garder une prise sur le monde, d’autant qu’il est partagé et porté par la congrégation. Néanmoins, aux yeux des soignantes en charge des religieuses aujourd’hui, il reste l’empreinte d’un temps qui n’aurait plus cours.
description: Women’s religious communities are aging. They adopt various strategies to cope with this phenomenon, including the transformation of parts of their convents into nursing homes for the elderly. Using photos as analytic tools, this article focuses on the habit, on clothes and on laundry as clues or hints of what persists and what vanishes. Signs of community life, holders of memory and witnesses to intimacy, the habit, clothes and laundry reveal old age, dependency and bodies that are usually concealed. Despite age and its effects, the religious dress also acts as a marker of a preserved identity. The wearing of the habit represents a form of resistance to the injunctions of bodily discipline primarily directed at elderly women. Incorporated witnesses of the passing of time, it enables a grip on the world, especially since it is shared and carried by the congregation. However, in the eyes of the health caregivers in charge of the nuns today, the religious dress remains an imprint of a time that no longer exists.
Michael Egerding, Die Metaphorik der spätmittelalterlichen Mystik
Creators: name: Signori, Gabriela
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 20 (2001): Rottenburger Jahrbuch für Kirchengeschichte, Band 20
A new method for estimation and model selection: $ρ$-estimation
Creators: name: Baraud, Yannick
name: Birgé, Lucien
name: Sart, Mathieu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62

description: The aim of this paper is to present a new estimation procedure that can be applied in many statistical frameworks including density and regression and which leads to both robust and optimal (or nearly optimal) estimators. In density estimation, they asymptotically coincide with the celebrated maximum likelihood estimators at least when the statistical model is regular enough and contains the true density to estimate. For very general models of densities, including non-compact ones, these estimators are robust with respect to the Hellinger distance and converge at optimal rate (up to a possible logarithmic factor) in all cases we know. In the regression setting, our approach improves upon the classical least squares from many aspects. In simple linear regression for example, it provides an estimation of the coefficients that are both robust to outliers and simultaneously rate-optimal (or nearly rate-optimal) for large class of error distributions including Gaussian, Laplace, Cauchy and uniform among others.
description: 66 pages
Hochmittelalterliches Geschichtsbewußtsein im Spiegel nichthistoriographischer Quellen, hg. v. Hans-Werner Goetz
Creators: name: Signori, Gabriela
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 20 (2001): Rottenburger Jahrbuch für Kirchengeschichte, Band 20
title: Les religieuses âgées et leurs soignantes.
Hybridité des espaces, des temps et des appartenances dans des institutions de soins
title: Elderly nuns and their caregivers. The hybrid nature of space, time and belonging in care institutions.
Creators: name: Amiotte-Suchet, Laurent
Publisher: name: ethnographiques.org
Year: 2017
Subjects: Anthropologie
Ethnologie
Vieillissement
Religion
communauté religieuse
alliances
hybridité
ruses
Couvent
stratégies
religion, convent, old age, hybridity, strategies, tactics, alliances

description: Basé sur une enquête ethnographique menée en France dans trois couvents de religieuses apostoliques transformés en établissements d’hébergement pour personnes âgées dépendantes (EHPAD), cet article décrit la manière dont s’organise la vie quotidienne dans ces institutions de soins d’origine congréganiste. En analysant successivement l’agencement des espaces, la gestion du temps et les relations entre les acteurs (principalement des religieuses et des soignantes), je mets en évidence leur caractère éminemment hybride. L’ethnographie permet de rendre compte de la variété des modes d’action visant à établir des règles communes pour préserver la paix sociale. Si les références religieuses et civiles se trouvent fréquemment mises en tension, les frontières entre ces deux « mondes » se révèlent particulièrement poreuses. Les acteurs en présence n’hésitent pas à construire de nouvelles alliances pour contrôler leur quotidien.
description: This article is based on ethnographic research conducted in three apostolic convents in France that have been transformed into residential care institutions for the elderly (établissements d’hébergement pour personnes âgées dépendantes – EHPAD). It examines how everyday life is organized in these previously congregational, now lay, medical institutions. By successively analysing the layout of space, the management of time and the relations between different actors (mainly nuns and nursing staff), I point up the eminently hybrid nature of life in these institutions. An ethnographic approach makes it possible to showcase the array of actions aimed at establishing common rules to preserve social peace. While religious and lay references are often in tension, the boundary between these two “worlds” is actually quite porous. The actors involved do not hesitate to forge new alliances to gain a measure of control over their daily routines.
Residue Formulas for Prepotentials, Instanton Expansions and Conformal Blocks
Creators: name: Gavrylenko, P.
name: Marshakov, A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the extended prepotentials for the S-duality class of quiver gauge theories, considering them as quasiclassical tau-functions, depending on gauge theory condensates and bare couplings. The residue formulas for the third derivatives of extended prepotentials are proven, which lead to effective way of their computation, as expansion in the weak-coupling regime. We discuss also the differential equations, following from the residue formulas, including the WDVV equations, proven to be valid for the $SU(2)$ quiver gauge theories. As a particular example we consider the constrained conformal quiver gauge theory, corresponding to the Zamolodchikov conformal blocks by 4d/2d duality. In this case part of the found differential equations turn into nontrivial relations for the period matrices of hyperelliptic curves.
description: 36 pages; typos corrected due to remarks of the authors of arXiv:1502.05581
Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A.
Creators: name: Cacioppo, Roberta
name: Lindon, Catherine
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Transcription
Translation
Cell cycle
Oncogene
Mrna Processing
Aurora Kinase A
Cell Line, Tumor
Animals
Mammals
Humans
Cell Cycle
Gene Amplification
Gene Expression Regulation, Neoplastic

description: Funder: Department of Pharmacology David James Fund
description: Aurora Kinase A (AURKA) is a positive regulator of mitosis with a strict cell cycle-dependent expression pattern. Recently, novel oncogenic roles of AURKA have been uncovered that are independent of the kinase activity and act within multiple signalling pathways, including cell proliferation, survival and cancer stem cell phenotypes. For this, cellular abundance of AURKA protein is per se crucial and must be tightly fine-tuned. Indeed, AURKA is found overexpressed in different cancers, typically as a result of gene amplification or enhanced transcription. It has however become clear that impaired processing, decay and translation of AURKA mRNA can also offer the basis for altered AURKA levels. Accordingly, the involvement of gene expression mechanisms controlling AURKA expression in human diseases is increasingly recognized and calls for much more research. Here, we explore and create an integrated view of the molecular processes regulating AURKA expression at the level of transcription, post-transcription and translation, intercalating discussion on how impaired regulation underlies disease. Given that targeting AURKA levels might affect more functions compared to inhibiting the kinase activity, deeper understanding of its gene expression may aid the design of alternative and therapeutically more successful ways of suppressing the AURKA oncogene.
Reconstructing the paleo-ecological diet of snow petrels (Pagodroma nivea) from modern samples and fossil deposits : implications for southern ocean paleoenvironmental reconstructions
Creators: name: Berg, S.
name: Emmerson, L.
name: Heim, C.
name: Buchta, E.
name: Fromm, T.
name: Glaser, Bruno
name: Hermichen, W.-D.
name: Rethemeyer, J.
name: Southwell, C.
name: Wand, U.
name: Zech, M.
name: Melles, Martin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 598

description: Snow petrels (Pagodroma nivea), which are endemic to the Antarctic region, produce proventricular stomach oil from ingested food for feeding purposes but also spit the oil in the immediate surrounds of the nests, where it forms encrustations over time (Antarctic mumiyo). These deposits provide a unique opportunity to understand the paleo-ecological diet of snow petrels and because the seabirds forage in the ocean, they potentially provide an archive of past marine environmental conditions in the Southern Ocean. For validating methods for reconstructions we use compositional data obtained on modern stomach oils and DNA data from fecal samples of snow petrels. We find that the distribution of carboxylic acid compounds in modern stomach oils and in the fossil deposits are consistent with variable contributions of fish and krill, which are the main constituents of modern snow petrel diet, and allows inference of past changes in snow petrel diet from the fossil record. Analyses of mumiyo deposits from six regions in East Antarctica reveal systematic differences in the isotopic composition of organic matter (δ13C and δ15N) and carboxylic acid patterns. This may suggest regional and/or temporal variability in the composition of snow petrels diet, likely differing in response to the prevailing environmental conditions in the foraging range of the birds, such as sea-ice variability, polynya activity and primary productivity. Our study provides confidence for using these approaches for broader scale paleo-studies in the future and for an assessment of the temporal changes and regional variability in snow petrel diet.
Quantum Monte Carlo for Noncovalent Interactions: An Efficient Protocol Attaining Benchmark Accuracy
Creators: name: Dubecký, Matúš
name: Derian, René
name: Jurečka, Petr
name: Mitas, Lubos
name: Hobza, Pavel
name: Otyepka, Michal
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Reliable theoretical predictions of noncovalent interaction energies, which are important e.g. in drug-design and hydrogen-storage applications, belong to longstanding challenges of contemporary quantum chemistry. In this respect, the fixed-node diffusion Monte Carlo (FN-DMC) is a promising alternative to the commonly used "gold standard" coupled-cluster CCSD(T)/CBS method for its benchmark accuracy and favourable scaling, in contrast to other correlated wave function approaches. This work is focused on the analysis of protocols and possible tradeoffs for FN-DMC estimations of noncovalent interaction energies and proposes an efficient yet accurate computational protocol using simplified explicit correlation terms with a favorable O(N^3) scaling. It achieves an excellent agreement (mean unsigned error ~0.2 kcal/mol) with respect to the CCSD(T)/CBS data on a number of complexes, including benzene/hydrogen,T-shape benzene dimer, stacked adenine-thymine and a set of small noncovalent complexes A24. The high accuracy and reduced computational costs predestinate the reported protocol for practical interaction energy calculations of large noncovalent complexes, where the CCSD(T)/CBS is prohibitively expensive.
Therapeutic Efficacy of GDNF Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson`s Disease Models
Creators: name: Ucar, Buket
name: Humpel, Christian
Publisher: name: Zenodo
Year: 2018
Subjects: GDNF
collagen scaffold
Parkinson´s disease

description: In this talk, our study with the aim of assessing neuroprotective effects of collagen scaffolds loaded with GDNF on dopaminergic neuron survival in ex vivo axotomy, rotenone-induced and 6-OHDA-induced models of PD was briefly explained.
description: {"references": ["Lin L-FH,Doherty DH,Lile JD,Bektesh S,Collins F. (1993) Science. 260, 1130\u20131132.", "Foidl BM,Ucar B,Schwarz A,Rebelo AL,Pandit A,Humpel C. (2018) J Neurosci Methods. 1;295:77-86"]}
title: NOVA Contemporary Music Journal, Volume 3, Issue I (2023)
title: Musical Performance as Creation (II)
titleType: Subtitle
Creators: name: Pires, Isabel
name: Magalhães, Filipa
name: Wanke, Riccardo
Publisher: name: CESEM, Faculdade de Ciências Sociais e Humanas, Universidade NOVA de Lisboa
Year: 2023

description: From the concert hall to the museum, from the street to private spaces, from live contexts to listening to recordings, from television to streaming systems, listening to music is today a subject that deserves our attention. Discussing music listening is crucial due to the diverse genres and sound art practices, as sound, music, and noise are omnipresent, shaping our environment and profoundly impacting our daily lives. In 2020, UNESCO recognized music’s role in cognitive development, learning, memorization, and skill acquisition. Listeners navigate a complex, saturated musical landscape with diverse streams and listening options.\r\n\r\nPassive uniformity, reduced concentration, aversion to complexity, cultural isolation, and limited engagement shape modern music listening and our environment. Over one billion young people risk hearing loss due to loud music. How does constant sound affect our focus and listening? Can sound and music be seen as pollution? How can sound ecology address this, and what role does music play in today’s sonic landscape, impacting society?\r\n\r\nComposers and performers are increasingly interested in listening to their own compositions and performances. In the latter half of the 20th century, space emerged as an integral musical parameter, with figures such as Stockhausen, Xenakis, Lucier, and many others contributing to this development. Today, the perceptual and cognitive potential of music pieces represents a new frontier for exploration. To what extent does listening influence the creative process? Can new listening modalities enhance our approach to historical music?\r\n\r\nIn a performative context, new listening situations are on the rise. Audiences and performers are actively engaged in innovative auditory experiences, including multimodal, virtual, and immersive encounters. How do these listening modalities influence the appreciation of a musical piece? To what extent is the listening process influenced or restricted by the context in which it occurs? What role does music listening play in settings like museum exhibitions, sound installations, or sound art events? What are the purposes and potentials of music listening in public and open spaces?
description: Pires, I., Magalhães, F., Wanke, R. (Eds.). (2023). Musical Performance as Creation; Nova Contemporary Music Journal (Vol. 3, Issue I). Centro de Estudos de Sociologia e Estética Musical, Lisboa. ISSN 2795-4803.
Schriftlichkeit und Lebenspraxis im Mittelalter
Creators: name: Eberl, Immo
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 20 (2001): Rottenburger Jahrbuch für Kirchengeschichte, Band 20
Solubilization, purification, and characterization of the hexameric form of phosphatidylserine synthase from Candida albicans
Creators: name: Zhou, Yue
name: Syed, Jawhar H.
name: Semchonok, Dmitry A.
name: Wright, Edward
name: Kyrilis, Fotis L.
name: Hamdi, Farzad
name: Kastritis, Panagiotis L.
name: Bruce, Barry D.
name: Reynolds, Todd B.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 580

description: Phosphatidylserine (PS) synthase from Candida albicans, encoded by the CHO1 gene, has been identified as a potential drug target for new antifungals against systemic candidiasis. Rational drug design or small molecule screening are effective ways to identify specific inhibitors of Cho1, but both will be facilitated by protein purification. Due to the transmembrane nature of Cho1, methods were needed to solubilize and purify the native form of Cho1. Here, we used six non-ionic detergents and three styrene maleic acids (SMAs) to solubilize an HA-tagged Cho1 protein from the total microsomal fractions. Blue native PAGE and immunoblot analysis revealed a single band corresponding to Cho1 in all detergent-solubilized fractions, while two bands were present in the SMA2000-solubilized fraction. Our enzymatic assay suggests that digitonin- or DDM-solubilized enzyme has the most PS synthase activity. Pull-downs of HA-tagged Cho1 from the digitonin-solubilized fraction reveal an apparent MW of Cho1 consistent with a hexamer. Furthermore, negative-staining electron microscopy analysis and AlphaFold2 structure prediction modeling suggest the hexamer is composed of a trimer of dimers. We purified Cho1 protein to near-homogeneity as a hexamer using affinity chromatography and TEV protease treatment, and optimized Cho1 enzyme activity for manganese and detergent concentrations, temperature (24 °C), and pH (8.0). The purified Cho1 has a Km for its substrate CDP-diacylglycerol of 72.20 μM with a Vmax of 0.079 nmol/(μg∗min) while exhibiting a sigmoidal kinetic curve for its other substrate serine, indicating cooperative binding. Purified hexameric Cho1 can potentially be used in downstream structure determination and small drug screening.
Pest defences under weak selection exert a limited influence on the evolution of height growth and drought avoidance in marginal pine populations.
Creators: name: Liu, Yang
name: Erbilgin, Nadir
name: Ratcliffe, Blaise
name: Klutsch, Jennifer G
name: Wei, Xiaojing
name: Ullah, Aziz
name: Cappa, Eduardo Pablo
name: Chen, Charles
name: Thomas, Barb R
name: El-Kassaby, Yousry A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Climate change
Drought
Forest pests
Pinus Contorta
Trait Interactions
Common-garden Approach
Pinus
Trees
Droughts
Climate Change
Forests

description: Funder: University of Cambridge
description: While droughts, intensified by climate change, have been affecting forests worldwide, pest epidemics are a major source of uncertainty for assessing drought impacts on forest trees. Thus far, little information has documented the adaptability and evolvability of traits related to drought and pests simultaneously. We conducted common-garden experiments to investigate how several phenotypic traits (i.e. height growth, drought avoidance based on water-use efficiency inferred from δ13C and pest resistance based on defence traits) interact in five mature lodgepole pine populations established in four progeny trials in western Canada. The relevance of interpopulation variation in climate sensitivity highlighted that seed-source warm populations had greater adaptive capability than cold populations. In test sites, warming generated taller trees with higher δ13C and increased the evolutionary potential of height growth and δ13C across populations. We found, however, no pronounced gradient in defences and their evolutionary potential along populations or test sites. Response to selection was weak in defences across test sites, but high for height growth particularly at warm test sites. Response to the selection of δ13C varied depending on its selective strength relative to height growth. We conclude that warming could promote the adaptability and evolvability of growth response and drought avoidance with a limited evolutionary influence from pest (biotic) pressures.
Information-based measure of nonlocality
Creators: name: Montina, Alberto
name: Wolf, Stefan
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Quantum nonlocality concerns correlations among spatially separated systems that cannot be classically explained without post-measurement communication among the parties. Thus, a natural measure of nonlocal correlations is provided by the minimal amount of communication required for classically simulating them. In this paper, we present a method to compute the minimal communication cost, which we call nonlocal capacity, for any general nonsignaling correlations. This measure turns out to have an important role in communication complexity and can be used to discriminate between local and nonlocal correlations, as an alternative to the violation of Bell's inequalities.
description: Substantial improvements have been made to the readablity of the paper. In particular, we provide a detailed justification of the adopted measure of communication. The order of Theorem 1 and 2 has been swapped and we have first considered the case of single-shot simulations, which gives a clearer clue of the ideas used for the case of parallel simulations. An appendix added