cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the impact of maximum residue limit standards on the vegetable trade in Japan
Creators: name: Choi, Jong Woo
name: Yue, Chengyan
name: Choi, Jong Woo
name: Yue, Chengyan
Publisher: name: Unknown
Year: 2016
Subjects: subject: Crop Production/Industries
subject: Food Consumption/Nutrition/Food Safety
subject: food safety
subject: Japan
subject: MRL
subject: pesticides
subject: vegetable

description: Countries have become increasingly concerned about the safety of their food. Many countries have imposed standards on both domestically produced and imported food. In particular, countries have implemented regulations to control the quantity and quality of vegetable imports. Maximum Residue Limit (MRL) standards are one of the main restrictions adopted by numerous countries. Japan has one of the strictest MRL standards in the world. This study builds on previous studies to explore the impact of MRL standards on Japanese vegetable imports. Gravity models are used to analyze how MRL standards influence the Japanese imports of different types of vegetables (fruit vegetables, leafy vegetables, bulb vegetable, and root vegetables). The results reveal that the trade impacts of MRL standards are different for different types of vegetables, with the most significant impact on imports of leafy and fruit vegetables and the least significant impact on imports of bulb vegetables.
Existence and Uniqueness for Nonlinear Integro-Differential Equations in Real Locally Complete Spaces
Creators: name: Gilsdorf, Thomas E.
name: Khavanin, Mohammad
Publisher: name: arXiv
Year: 2020
Subjects: subject: Functional Analysis (math.FA)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: Primary: 45D05, 34K20, Secondary: 46A17, 46A13

description: We extend existence and uniqueness results of [4] for nonlinear integro-differential equations of Volterra type between real locally complete vector spaces
Self-Organized Bottleneck in Energy Relaxation
Creators: name: Morita, Hidetoshi
name: Kaneko, Kunihiko
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study an energy relaxation process after many degrees of freedom are excited in a Hamiltonian system with a large number of degrees of freedom. Bottlenecks of relaxation, where relaxations of the excited elements are drastically slowed down, are discovered. By defining an internal state for the excited degrees of freedom, it is shown that the drastic slowing down occurs when the internal state is in a critical state. The relaxation dynamics brings the internal state into the critical state, and the critical bottleneck of relaxation is self-organized. Relevance of our result to relaxation phenomena in condensed matters or large molecules is briefly discussed.
description: 4pages, 5 figures
Additional file 2 of Dispersal and genetic structure in a tropical small mammal, the Bornean tree shrew (Tupaia longipes), in a fragmented landscape along the Kinabatangan River, Sabah, Malaysia
Creators: name: Brunke, Jennifer
name: Isa-Rita M. Russo
name: Orozco-TerWengel, Pablo
name: Zimmermann, Elke
name: Bruford, Michael W.
name: Benoit Goossens
name: Radespiel, Ute
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology

description: Additional file 2 Table S5Cytochrome b haplotypes in T. longipes (n = 60) and their spatial distribution (upstream → downstream) along the northern (NA–ND) and southern (SE–SI) riverside. Figure S1: Haplotype network based on cyt b sequences.
Entropic nonextensivity as a measure of time series complexity
Creators: name: Rajkovic, Milan
Publisher: name: arXiv
Year: 2004
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Information entropy is applied to the analysis of time series generated by dynamical systems. Complexity of a temporal or spatio-temporal signal is defined as the difference between the sum of entropies of the local linear regions of the trajectory manifold and the entropy of the globally linearized manifold. When the entropies are Tsallis entropies the complexity is characterized by the value of q.
description: 6 pages, 2 figures, to appear in Physica A
Stratigraphie und Morphogenese von frühpleistozänen Ablagerungen zwischen Bodensee und Klettgau
Creators: name: Graf, Hans Rudolf
Publisher: name: Geozon Science Media
Year: 2009

description: Anhand von Feldaufnahmen, sedimentpetrographischen Untersuchungen sowie einer systematischen Auswertung von Literaturangaben und Bohraufnahmen wurde eine Neubearbeitung von Stratigrafie und Paläogeografie der Deckenschotter des Bodensee-Rheingletschersystems im Raum zwischen Bodensee und Schaffhausen sowie im Klettgau vorgenommen. Es konnten drei morphostratigraphischen Einheiten unterschieden werden: (a) Höhere Deckenschotter, (b) Tiefere Deckenschotter sowie (c) Tiefere Deckenschotter, unteres Niveau. Die Höheren Deckenschotter können lithostratigrafisch nicht weiter gegliedert werden. Die Tieferen Deckenschotter umfassen Ablagerungen aus mindestens zwei kaltzeitlichen Sedimentationsphasen. Es gibt Hinweise, dass zwischen den Sedimentationsphasen temperierte Verhältnisse herrschten. Die jüngste Einheit, „Tieferen Deckenschotter, unteres Niveau“, entstand nach einer markanten erosiven Umgestaltung des regionalen Entwässerungsnetzes, in einer einzigen Phase. Eine Analyse der tektonischen Verhältnisse im Untersuchungsgebiet ergab, dass die Höhenlagen der einzelnen Deckenschottervorkommen keine wesentlichen Verfälschungen durch neotektonische Vorgänge aufweisen. Einzig die östlich der Immensee-Verwerfung gelegenen Vorkommen im Hegau könnten eine relative tektonische Verstellung erfahren haben, da sie im Vergleich zu den talwärtigen Korrelaten topographisch ungewöhnlich hoch liegen. Die vorgeschlagene morphostratigraphische Gliederung wird dadurch jedoch nicht in Frage gestellt. Die Kontrolle des Vorflutniveaus und damit der morphogenetischen Entwicklung des Untersuchungsgebietes erfolgte dominant durch tektonische Vorgänge im Oberrheingrabensystem (Absenkung). Dies gilt auch für die Deckenschotter der zentralen Nordschweiz, weshalb die morphostratigraphischen Einheiten dieser beiden Gebiete miteinander korreliert werden können, wenngleich die Zahl der unterscheidbaren lithostratigraphischen Einheiten nicht übereinstimmt. Für die Höheren Deckenschotter kann das entweder auf eine unvollständige Überlieferung im Untersuchungsgebiet bzw. eine mangelnde Datendichte zurückzuführen sein; es könnte aber auch darauf hindeuten, dass die Verbindung Bodensee–Oberrheingraben später als die Verbindung Walenseetal–Oberrheingraben installiert wurde. Eine Korrelation mit den auf das Donau-System ausgerichteten frühpleistozänen Ablagerungen des süddeutschen Alpenvorlandes ist anhand von morpho- und lithostratigraphischen Kriterien allein nicht möglich.
description: research
Proper motions and velocity asymmetries in the RW Aur jet
Creators: name: Lopez-MArtin, L.
name: Cabrit, S.
name: Dougados, C.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present adaptive optics spectro-imaging observations of the RW Aur jet in optical forbidden lines, at an angular resolution of 0.4 arcsec. Comparison with HST data taken 2 years later shows that proper motions in the blueshifted and redshifted lobes are in the same ratio as their radial velocities, a direct proof that the velocity asymmetry in this jet is real and not an emissivity effect. The inferred jet inclination to the line of sight is i = 46 +/- 3 degrees. The inner knot spacing appears best explained by time variability with at least two modes: one irregular and asymmetric (possibly random) on timescales of <3-10 yr, and another more regular with ~ 20 yr period. We also report indirect evidence for correlated velocity and excitation gradients in the redshifted lobe, possibly related to the blue/red velocity and brightness asymmetry in this system.
description: 4 pags, 3 figures
A flexible approach to age dependence in organizational mortality. Comparing the life duration of cooperative and non-cooperative enterprises using a Bayesian Generalized Additive Discrete Time Survival Model
Creators: name: Rousselière, Damien
name: Rousselière, Damien
Publisher: name: Unknown
Year: 2017
Subjects: subject: Agribusiness
subject: Bayesian estimation
subject: Bayesian model selection
subject: cooperatives
subject: generalized additive
subject: model
subject: survival analysis

description: This paper proposes a new estimation model to capture the complex effect of age on organization survival. Testing various theoretical propositions on organizational mortality, we study the survival of French agricultural cooperatives in comparison with other firms with which they compete. The relationship between age and mortality in organizations is analyzed using a Bayesian Generalized discrete-time semi-parametric hazard model with correlated random effects, incorporating unobserved heterogeneity and isolating the various effects of time. This analysis emphasizes the specificity of the temporal dynamics of cooperatives in relation to their special role in agriculture.
Acolpenteron ureteroecetes Fischthal & Allison 1940
Creators: name: Mendoza-Garfias, Berenit
name: García-Prieto, Luis
name: León, Gerardo Pérez-Ponce De
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Monogenea
Dactylogyridea
Dactylogyridae
Acolpenteron
Acolpenteron ureteroecetes

description: Acolpenteron ureteroecetes Fischthal & Allison, 1940 *
 Acolpenteron ureteroecetes Fischthal & Allison, 1940: 517.
HOSTS. — Actinopterygii; Ureter, urinary bladder.
 GEOGRAPHIC DISTRIBUTION. — Nuevo León. Laguna de Salinillas, Presa Cerro Prieto (Linares), Presa El Cuchillo (Solidaridad), Presa Rodrígo Gómez (La Boca), Presa Sombreretillo: Micropterus salmoides (Galavíz-Silva et al. 2015).
SPECIMENS IN COLLECTIONS. — CNHE (9821).
description: Published as part of Mendoza-Garfias, Berenit, García-Prieto, Luis & León, Gerardo Pérez-Ponce De, 2017, Checklist of the Monogenea (Platyhelminthes) parasitic in Mexican aquatic vertebrates, pp. 501-598 in Zoosystema 39 (4) on page 509, DOI: 10.5252/z2017n4a5, http://zenodo.org/record/4578694
Über Aufbau und Altersgliederung des Holozäns der Lüneburger Elbmarsch
Creators: name: Benzler, Jobst-Henrich
Publisher: name: Geozon Science Media
Year: 1965

description: Zu Beginn des Holozäns waren die glazifluviatilen Sande des Elburstromtales von Schmelzwasserrinnen durchzogen, in denen teilweise die alten Elbarme verliefen. Diese Sande wurden zu Dünen aufgeweht, auf denen sich Podsole bildeten. Während des gesamten Holozäns lagerte die Elbe an ihren Ufern lehmig-sandige, im Hinterland tonreiche Sedimente ab, die sich mit Torfen in verlandeten Altarmen und im Sietland verzahnen. Die Bedeichung im Mittelalter beendete die allgemeine Sedimentation. Nur bei Deichbrüchen kamen örtlich fächerförmige Sanddecken zur Ablagerung. Das Alter von Torflagen und Humusdwögen innerhalb der tonigen Sedimente wurde mittels 14C-Untersuchung bestimmt, ebenso von Holzkohle aus den Dünenpodsolen.
description: research
Intensity of Coulomb Interaction between quasiparticles in diffusive metallic wires
Creators: name: Huard, B.
name: Anthore, A.
name: Pierre, F.
name: Pothier, H.
name: Birge, Norman O.
name: Esteve, D.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The energy dependence and intensity of Coulomb interaction between quasiparticles in metallic wires is obtained from two different methods: determination of the temperature dependence of the phase coherence time from the magnetoresistance, and measurements of the energy distribution function in out-of-equilibrium situations. In both types of experiment, the energy dependence of the Coulomb interaction is found to be in excellent agreement with theoretical predictions. In contrast, the intensity of the interaction agrees closely with theory only with the first method, whereas an important discrepancy is found using the second one. Different explanations are proposed, and results of a test experiment are presented.
description: Submitted to Solid States Communications
A physical template family for gravitational waves from precessing binaries of spinning compact objects: Application to single-spin binaries
Creators: name: Pan, Yi
name: Buonanno, Alessandra
name: Chen, Yanbei
name: Vallisneri, Michele
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The detection of the gravitational waves (GWs) emitted by precessing binaries of spinning compact objects is complicated by the large number of parameters (such as the magnitudes and initial directions of the spins, and the position and orientation of the binary with respect to the detector) that are required to model accurately the precession-induced modulations of the GW signal. In this paper we describe a fast matched-filtering search scheme for precessing binaries, and we adopt the physical template family proposed by Buonanno, Chen, and Vallisneri [Phys.Rev.D 67, 104025 (2003)] for ground-based interferometers. This family provides essentially exact waveforms, written directly in terms of the physical parameters, for binaries with a single significant spin, and for which the observed GW signal is emitted during the phase of adiabatic inspiral (for LIGO-I and VIRGO, this corresponds to a total mass M < 15Msun). We show how the detection statistic can be maximized automatically over all the parameters (including the position and orientation of the binary with respect to the detector), except four (the two masses, the magnitude of the single spin, and the opening angle between the spin and the orbital angular momentum), so the template bank used in the search is only four-dimensional; this technique is relevant also to the searches for GW from extreme--mass-ratio inspirals and supermassive blackhole inspirals to be performed using the space-borne detector LISA. Using the LIGO-I design sensitivity, we compute the detection threshold (~10) required for a false-alarm probability of 10^(-3)/year, and the number of templates (~76,000) required for a minimum match of 0.97, for the mass range (m1,m2)=[7,12]Msun*[1,3]Msun.
description: 27 pages, 11 figures; reference added for Sec. 6, typos corrected; small corrections to GW flux terms as per Blanchet et al., PRD 71, 129902(E)-129904(E) (2005)
On vacuum energies and renormalizability in integrable quantum field theories
Creators: name: Castro-Alvaredo, Olalla
name: Fring, Andreas
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute for various perturbed conformal field theories the vacuum energies by means of the thermodynamic Bethe ansatz. Depending on the infrared and ultraviolet divergencies of the models, governed by the scaling dimensions of the underlying perturbed conformal field theory in the ultraviolet, the vacuum energies exhibit different types of characteristics. In particular, for the homogeneous sine-Gordon models we observe that once the conformal dimension of the perturbing scalar field is smaller or greater than 1/2, the vacuum energies are positive or negative, respectively. This behaviour indicates the need for additional ultraviolet counterterms in the latter case. At the transition points we obtain an infinite vacuum energy, which is partly explainable with the presence of several free Fermions in the models studied.
description: 20 pages, Latex, reference added, typos corrected
Zero-point gravitational field equations
Creators: name: Pesci, Alessandro
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the recently reported qmetric (or zero-point-length) expressions of the Ricci (bi)scalar $R_{(q)}$ (namely, expressions of the Ricci scalar in a spacetime with a limit length $L_0$ built in), focusing specifically on the case of null separated events. A feature of these expressions is that, when considered in the coincidence limit $p \to P$, they generically exhibit a dependence on the geodesic along which the varying point $p$ approached $P$, sort of memory of how $p$ went to $P$. This fact demands a deeper understanding of the meaning of the quantity $R_{(q)}$, for this latter tells about curvature of spacetime as a whole at $P$ and would not be supposed to depend on whichever vector we might happen to consider at $P$. Here, we try to search for a framework in which these two apparently conflicting aspects might be consistently reconciled. We find a tentative sense in which this could be achieved by endowing spacetime of a specific operational meaning. This comes, however, at the price (or with the benefit) of having a spacetime no longer arbitrary but, in a specific sense, constrained. The constraint turns out to be in the form of a relation between spacetime geometry in the large scale (as compared to $L_0$) and the matter content, namely as sort of field equations. This comes thanks to something which happens to coincide with the expression of balance of (matter and spacetime) exchanged heats, i.e. the thermodynamic variational principle from which the field equations have been reported to be derivable. This establishes a link between (this specific, operational understanding of) the meaning of the limit expression of $R_{(q)}$ on one side and the (large-scale) field equations on the other, this way reconnecting (once more) the latter to a quantum feature.
description: 17 pages; v2: some corrections/editing/clarifications, reference added, it corresponds to the published version
The Athena X-IFU end-to-end simulator
Creators: name: Kirsch, Christian
name: Lorenz, Maximilian
name: König, Ole
name: Dauner, Lea
name: Dauser, Thomas
name: Cucchetti, Edoardo
name: Peille, Philippe
name: Ceballos, Maria Teresa
name: Cobo, Beatriz
name: Acero, Fabio
name: Decourchelle, Anne
name: Wilms, Jörn
Publisher: name: Zenodo
Year: 2022
Subjects: X-IFU
SIXTE
Simulator

description: We present the implementation of the official simulator of the Athena X-IFU instrument within the SIXTE end-to-end simulation package. For the X-IFU, SIXTE implements all relevant physical effects that are necessary for a faithful representation of the imaging spectroscopy capabilities of the instrument. SIXTE can therefore be used to simulate X-IFU observations of point sources and extended sources, including sources with spatially variable spectral shapes and very bright sources. Examples of the microcalorimeter effects that are implemented are event grading and crosstalk. These effects cause the energy reconstruction of an X-ray event to be affected by photons impacting either on the same pixel or on different pixels coupled via the focal plane or the readout chain, respectively. The different types of crosstalk are parametrized using both laboratory data and physics simulations with the X-IFU instrument simulator xifusim. As a result of these effects, the X-IFU performance degrades for very bright sources. To mitigate this degradation, the simulator can be operated in different observation modes, such as the use of Be filters to block lower energy photons and a defocused mode, which spreads events from a point source over the whole detector.
Large-N transitions for generalized Yang-Mills theories in 1+1 dimensions
Creators: name: Dubath, Florian
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We describe the entire phase structure of a large number of colour generalized Yang-Mills theories in 1+1 dimensions. This is illustrated by the explicit computation for a quartic plus quadratic model. We show that the Douglas-Kazakov and cut-off transitions are naturally present for generalized Yang-Mills theories separating the phase space into three regions: a dilute one a strongly interacting one and a degenerate one. Each region is separated into sub-phases. For the first two regions the transitions between sub-phases are described by the Jurekiewicz-Zalewski analysis. The cut-off transition and degenerated phase arise only for a finite number of colours. We present second-order phase transitions between sub-phases of the degenerate phase.
description: 18 pages, 4 figures, exemple and some references added
The emergence and proliferation of agroholdings and mega farms in a global context
Creators: name: Hermans, Frans L. P.
name: Chaddad, Fabio R.
name: Gagalyuk, Taras
name: Senesi, Sebastian
name: Balmann, Alfons
name: Hermans, Frans L. P.
name: Chaddad, Fabio R.
name: Gagalyuk, Taras
name: Senesi, Sebastian
name: Balmann, Alfons
Publisher: name: Unknown
Year: 2017
Subjects: subject: Agribusiness
subject: Farm Management
subject: agroholdings
subject: mega farms
subject: integration
subject: farm size

description: During the last two decades an increasing amount of large-scale farming operations have emerged all over the world: from (Eastern) Europe, to South America, China and the countries of the Former Soviet Union. These agribusinesses go under the name of mega-farms or agroholdings: horizontally or vertically integrated operations with farm sizes of up to 500,000 hectares and sometimes even more. These types of farms are not only found in crop farming, but also in animal husbandry. Although some information on agroholdings and other forms of mega-farming operations is available, a systematic analysis of their prevalence, economic performance as well as their social and environmental implications in an international perspective is missing. In this special issue of the International Food and Agribusiness Management Review we present a number of papers that highlight the different aspects of such farms. In this editorial we introduce the topic of agroholdings and place the papers in within the context of the available literature. We end with the presentation of a research agenda for the future.
Ehemalige Ammerseestände im Hoch- und Spätglazial des Würm
Creators: name: Feldmann, Ludger
Publisher: name: Geozon Science Media
Year: 1992

description: Auf der Grundlage terrassenmorphologischer Untersuchungen im oberen Ampertal lassen sich neben dem rezenten Ammerseespiegel von 533 m NN alte Seespiegel bei 565 m, 561 m, 555 m, 544m, 542 m und 536m rekonstruieren. Die Datierung dieser Seespiegel ergibt sich aus morphologischen und pedologischen Beobachtungen, wobei die zwei höchsten Wasserstände keinem Seespiegel, sondern einem Gerinne auf Toteis entsprechen. Die Absenkung von 565 auf 561m NN erfolgte nach dem Ammerseestadium, die folgende auf 555 m NN an der Wende vom Hoch- zum Spätglazial, wobei der Seespiegel von 536m NN sehr wahrscheinlich erst in der Jüngeren Dryas erreicht wurde. Die Zerschneidung der Endmoränen und damit die Erniedrigung des Ammerseespiegels hat vermutlich sehr viel länger gedauert, als bisher angenommen wurde.
description: research
Universality of Parametric Spectral Correlations: Local versus Extended Perturbing Potentials
Creators: name: Marchetti, F. M.
name: Smolyarenko, I. E.
name: Simons, B. D.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We explore the influence of an arbitrary external potential perturbation V on the spectral properties of a weakly disordered conductor. In the framework of a statistical field theory of a nonlinear sigma-model type we find, depending on the range and the profile of the external perturbation, two qualitatively different universal regimes of parametric spectral statistics (i.e. cross-correlations between the spectra of Hamiltonians H and H+V). We identify the translational invariance of the correlations in the space of Hamiltonians as the key indicator of universality, and find the connection between the coordinate system in this space which makes the translational invariance manifest, and the physically measurable properties of the system. In particular, in the case of localized perturbations, the latter turn out to be the eigenphases of the scattering matrix for scattering off the perturbing potential V. They also have a purely statistical interpretation in terms of the moments of the level velocity distribution. Finally, on the basis of this analysis, a set of results obtained recently by the authors using random matrix theory methods is shown to be applicable to a much wider class of disordered and chaotic structures.
description: 16 pages, 7 eps figures (minor changes and reference [17] added)
One-way street for the energy current: A ubiquitous phenomenon in boundary-driven quantum spin chains
Creators: name: Oliveira, Deborah
name: Pereira, Emmanuel
name: Lemos, Humberto C F
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Focusing on the description of nontrivial properties of the energy transport at quantum scale, we investigate asymmetrical quantum spin chains described by boundary-driven $\mathit{XXZ}$ and $\mathit{XXX}$ Heisenberg models. We search for symmetries properties of the Lindblad master equation related to the dynamics of the system in order to establish properties of the steady state. Under rather general assumptions for the target polarization at the boundaries, we show the occurrence of an effect related to (but stronger than) energy rectification, namely, the one-way street phenomenon, which is the existence of an unique way for the energy flow. Precisely, the energy current does not change in magnitude and direction as we invert the baths at the boundaries: its direction is completely determined by the asymmetry in the bulk of the chain. The results follow independent of the system size and of the transport regime. Our findings show the ubiquitous occurrence of the one-way street phenomenon for the energy flow in boundary-driven spin systems and, we believe, they shall be an useful contribution to the area devoted to the investigation and building of efficient quantum devices used to control and manipulate the energy current.
title: Preclinical Models to study the Biology and Therapy of Ovarian Cancer
Creators: name: Bizzaro, Francesca
Publisher: name: The Open University
Year: 2021

description: Ovarian cancer (OC) is one of the most common gynaecological malignancies and a cause of mortality among western women. Standard-of-care treatment consists of platinum/taxane-based chemotherapy, but 5-years survival rate remains low.

 Germline and somatic mutations in BRCA are present in half of the high grade serous (HGS) ovarian cancer. Olaparib, a PARP inhibitor affecting DNA damage repair pathway, has been approved in the treatment of germline-BRCA-mutated patients. The combination with cediranib, an angiogenesis inhibitor, has shown promising results, increasing progression-free survival in women with recurrent HGS ovarian cancer.

 In this thesis, patient-derived ovarian cancer xenografts (OC-PDX) were used to study olaparib therapy and mechanisms underlying the observed benefit of the combination.

 Next Generation Sequencing and gene expression analysis were performed on OC-PDX to identify mutations/aberrations in BRCA1/2 and other genes connected to the DNA repair pathway. A cohort (n=13) of OC-PDX was selected and classified as BRCAness and Not BRCAness, accordingly to their proficiency or deficiency in DNA damage repair. Olaparib and cediranib were administered in short-term (4 weeks) or maintenance (until progression) regimens.

 Olaparib showed activity in BRCAness OC-PDX; the effect was improved by cediranib, inducing durable responses even after treatment suspension. Of note, the combination was also beneficial in Not BRCAness OC-PDX, promoting stable disease and regression.

 The effect of the combination on changes in tumor-associated vasculature and hypoxia (likely due to cediranib) and DNA damage repair (due to olaparib), together with preliminary data on gene expression and mutational status, suggested a potential “cumulative” effect of the combination after 4 weeks of treatment. Studies are ongoing, to understand the molecular determinants that accompany the response of OC-PDX to the combination.

 The results obtained compel us to believe that the combination of olaparib with cediranib is advantageous both in DNA repair proficient and, most importantly, in deficient patients, and has to be administered until tumor progression.
Risk factors, time to onset and recurrence of delirium in a mixed medical-surgical ICU population: a secondary analysis using Cox and CHAID decision tree modeling
Creators: name: Rahimibashar, Farshid
name: Miller, Andrew C.
name: Salesi, Mahmood
name: Bagheri, Motahareh
name: Vahedian-Azimi, Amir
name: Ashtari, Sara
name: Gohari Moghadam, Keivan
name: Sahebkar, Amirhossein
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2022
Subjects: delirium
Intensive Care Units
critical care
risk factors
Iran

description: A retrospective secondary analysis of 4,200 patients was collected from two academic medical centers. Delirium was assessed using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in all patients. Univariate and multivariate Cox models, logistic regression analysis, and Chi-square Automatic Interaction Detector (CHAID) decision tree modeling were used to explore delirium risk factors. Increased delirium risk was associated with exposed only to artificial light (AL) hazard ratio (HR) 1.84 (95 % CI: 1.66-2.044, P<0.001), physical restraint application 1.11 (95 % CI: 1.001-1.226, P=0.049), and high nursing care requirements (>8 hours per 8-hour shift) 1.18 (95 % CI: 1.048-1.338, P=0.007). Delirium incidence was inversely associated with greater family engagement 0.092 (95 % CI: 0.014-0.596, P=0.012), low staff burnout and anticipated turnover scores 0.093 (95 % CI: 0.014-0.600, P=0.013), non-ICU length-of-stay (LOS)<15 days 0.725 (95 % CI: 0.655-0.804, P<0.001), and ICU LOS ≤15 days 0.509 (95 % CI: 0.456-0.567, P<0.001). CHAID modeling indicated that AL exposure and age <65 years were associated with a high risk of delirium incidence, whereas SOFA score ≤11, APACHE IV score >15 and natural light (NL) exposure were associated with moderate risk, and female sex was associated with low risk. More rapid time to delirium onset correlated with baseline sleep disturbance (P=0.049), high nursing care requirements (P=0.019), and prolonged ICU and non-ICU hospital LOS (P<0.001). Delirium recurrence correlated with age >65 years (HR 2.198; 95 % CI: 1.101-4.388, P=0.026) and high nursing care requirements (HR 1.978, 95 % CI: 1.096-3.569), with CHAID modeling identifying AL exposure (P<0.001) and age >65 years (P=0.032) as predictive variables. Development of ICU delirium correlated with application of physical restraints, high nursing care requirements, prolonged ICU and non-ICU LOS, exposure exclusively to AL (rather than natural), less family engagement, and greater staff burnout and anticipated turnover scores. ICU delirium occurred more rapidly in patients with baseline sleep disturbance, and recurrence correlated with the presence of delirium on ICU admission, exclusive AL exposure, and high nursing care requirements.
description: EXCLI Journal; 21:Doc30; ISSN 1611-2156
Holozäner Landschaftswandel im südlichen Oberrheintiefland und Schwarzwald
Creators: name: Mäckel, Rüdiger
name: Friedmann, Arne
Publisher: name: Geozon Science Media
Year: 1999

description: Die Untersuchungen zum holozänen Landschaftswandel im südlichen Oberrheintiefland und Schwarzwald konzentrieren sich auf die Zeitscheibe II (5500 bis 3000 v. Chr.) und III (1500 v. Chr. bis 500 n. Chr.) des DFG-Schwerpunktprogramms „Wandel der Geo-Biosphäre während der letzten 15 000 Jahre - Kontinentale Sedimente als Ausdruck sich ändernder Umweltbedingungen". Trotz einiger neolithischer Funde in den klimabegünstigten Lößgebieten wird der spürbare Eingriff des Menschen in die Naturlandschaft erst ab der Bronzezeit durch Kolluvien (Lößlehm) und Auensedimente nachgewiesen. Ein verstärkter Einfluß des Menschen auf die Abtragungsprozesse ist in der vorrömischen Eisenzeit, vor allem in der Latènezeit, zu beobachten. Die Ursachen dafür sind die Ausweitung der landwirtschaftlichen Nutzflächen durch die wachsende Bevölkerung bei gleichzeitiger Klimaverschlechterung. Eine einschneidende Auswirkung auf den Landschaftshaushalt hat bereits der Bergbau in der Latènezeit. Der anthropogene Einfluß auf die Geomorphodynamik verstärkt sich zur Römerzeit durch intensive landwirtschaftliche Nutzung, Siedlungen und den Bergbau. Mit dem Rückzug der Römer verringert sich die Siedlungsaktivität, und es tritt eine Stabilitätsphase mit Regeneration der Vegetation und Bodenbildung ein. Die alamannische Landnahme wirkte sich nur in den lößbedeckten und klimabegünstigten Siedlungsgebieten des Oberrheintieflandes und der Vorbergzone aus. Insgesamt führten die Aktivitäten der vorrömischen Eisenzeit und der Römerzeit zu den schwerwiegendsten anthropogenen Veränderungen im Untersuchungsgebiet während der drei Zeitscheiben.
description: research
Conditional Spectroscopy via Non-Stationary Optical Homodyne Quantum State Tomography
Creators: name: Thewes, Johannes
name: Lüders, Carolin
name: Aßmann, Marc
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Continuous variable quantum state tomography is one of the most powerful techniques to study the properties of light fields in quantum optics. However, the need for a fixed phase reference has so far prevented widespread usage in other fields such as semiconductor spectroscopy. Here, we introduce non-stationary quantum state tomography, which adapts the technique to the special requirements of ultrafast spectroscopy. In detail, we gain access to the amplitude and phase of light fields with a temporal resolution of about 100\,fs without the need for a fixed phase reference. Further, we show how our technique allows us to perform conditional studies of stochastic dynamics that are inaccessible experimentally by conventional means, and demonstrate the capabilities experimentally by monitoring the stochastic dynamics of a thermal light field on the sub-ps scale. Finally, we discuss differences and similarities to more standard Hanbury Brown-Twiss photon correlation experiments, which may be considered as the discrete variable analogues of our technique.
description: 12 pages, 6 figures
Additional file 1 of Dispersal and genetic structure in a tropical small mammal, the Bornean tree shrew (Tupaia longipes), in a fragmented landscape along the Kinabatangan River, Sabah, Malaysia
Creators: name: Brunke, Jennifer
name: Isa-Rita M. Russo
name: Orozco-TerWengel, Pablo
name: Zimmermann, Elke
name: Bruford, Michael W.
name: Benoit Goossens
name: Radespiel, Ute
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology

description: Additional file 1 Table S1 Amplification characteristics of single (S) and multiplex (M) reactions and the respective microsatellite loci used in T. longipes. Table S2 Upper table: Genetic ([FST-values], upper matrix) and geographic (Euclidean) distances ([km], bottom matrix) among forest sites. Lower table: Mean relatedness (r, upper matrix) and geographic (Euclidean) distances ([km], bottom matrix) among and within forest sites. Table S3 Results from MWU test (Observed (Ho) and expected heterozygosity (He), inbreeding index (FIS), allelic richness, haplotype (h) and nucleotide (π) diversity, relatedness (r), on the northern and southern riverside, and relatedness (r), interindividual distances of related dyads (r ≥ 0.25), mAIc in males and females) or Levene’s test (vAIc in males and females). Tests were conducted for the whole sets and for within and among forest site/sampling location comparisons. Significant differences are in bold. Table S4 Relative proportion of individuals per site and riverside, respectively, which were assigned to one of the clusters under k = 2 (LnP(D): − 3112.2), with a probability of q > 80%.
Structure of strongly charged polyelectrolyte solutions
Creators: name: Donley, James P.
name: Heine, David R.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Molecular dynamics simulation and recent theory are used to examine density correlations in semidilute solutions of highly charged, intrinsically flexible and hydrophilic polyelectrolytes in low salt. Quantitative comparison with no adjustable parameters is made with recent scattering and osmometry experiments. Agreement is found for the polymer-polymer structure factor at intermediate wavevectors q with varying chain charge fraction f. Theory is also in agreement with simulation and experiment for the osmotic pressure, but not with q -> 0 extrapolations of scattering data that show anomalously large intensities at low q.
description: 6 pages, 3 figures
Australian agricultural scale and corporate agroholdings: environmental and climatic impacts
Creators: name: Plunkett, Bradley
name: Duff, Andrew
name: Kingwell, Ross
name: Feldman, David
name: Plunkett, Bradley
name: Duff, Andrew
name: Kingwell, Ross
name: Feldman, David
Publisher: name: Unknown
Year: 2016
Subjects: subject: Environmental Economics and Policy
subject: Farm Management
subject: climatic variability
subject: large scale agroholdings

description: The average size of Australian farms in scale and revenue are the globe’s largest. This scale is a result, in part, of low average rural population densities; development patterns in broadacre production; low levels of effective public policy transfers; a stable and suitable institutional setting suitable for corporate and other large scale investment; and low yields. It is also a factor of the natural variability of the country’s climatic systems which have contributed to the scale of extensive northern cattle production; this variability has implications for the pattern of ownership of broadacre and extensive production. Corporate ownership, tends to concentrate production aggregations at sufficient scale to offset its additional overheads in areas of relative climatic stability and to replicate these agroholding aggregations spatially to protect the stability of revenue flows. Family structures are more dominant in areas of greater climatic variability. Of interest is the impact that any increasing climatic variability (versus rapid changes in technology) may have upon this pattern.
Massive Young Clusters
Creators: name: Maíz-Apellániz, Jesús
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: In the last decade we have come to realize that the traditional classification of stellar clusters into open and globular clusters cannot be easily extended beyond the realm of the Milky Way, and that even for our Galaxy it is not fully valid. The main failure of the traditional classification is the existence of Massive Young Clusters (MYCs), which are massive like Globular Clusters (GCs) but also young like open clusters. We describe here the mass and age distributions of clusters in general with an emphasis on MYCs. We also discuss the issue of what constitutes a cluster and try to establish a general classification scheme.
description: 8 pages, 1 figure, to appear in "How does the Galaxy work? A Galactic tertulia with Don Cox and Ron Reynolds"
Scale farming operations in China
Creators: name: Huang, Zuhui
name: Guan, Lijun
name: Jin, Shaosheng
name: Huang, Zuhui
name: Guan, Lijun
name: Jin, Shaosheng
Publisher: name: Unknown
Year: 2016
Subjects: subject: Farm Management
subject: China
subject: scale farming operation
subject: farmland transfer
subject: agricultural service

description: Agriculture in China is often characterized as small-scale farming because of the limited farm sizes. However, in recent years the country has witnessed widespread increased-scale farming operations. In this paper, we aim to systematically illustrate the recent scale development of farming operations in China based on cases taken from Zhejiang province. Two main types of the scale farming operations in China are identified. These are based on: (1) concentrated farmland and (2) agricultural services. Finally, the trends of scale farming operations in China are discussed.
FiberStars: Visual Comparison of Diffusion Tractography Data between Multiple Subjects
Creators: name: Franke, Loraine
name: Weidele, Daniel Karl I.
name: Zhang, Fan
name: Cetin-Karayumak, Suheyla
name: Pieper, Steve
name: O'Donnell, Lauren J.
name: Rathi, Yogesh
name: Haehn, Daniel
Publisher: name: arXiv
Year: 2020
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Tractography from high-dimensional diffusion magnetic resonance imaging (dMRI) data allows brain's structural connectivity analysis. Recent dMRI studies aim to compare connectivity patterns across subject groups and disease populations to understand subtle abnormalities in the brain's white matter connectivity and distributions of biologically sensitive dMRI derived metrics. Existing software products focus solely on the anatomy, are not intuitive or restrict the comparison of multiple subjects. In this paper, we present the design and implementation of FiberStars, a visual analysis tool for tractography data that allows the interactive visualization of brain fiber clusters combining existing 3D anatomy with compact 2D visualizations. With FiberStars, researchers can analyze and compare multiple subjects in large collections of brain fibers using different views. To evaluate the usability of our software, we performed a quantitative user study. We asked domain experts and non-experts to find patterns in a tractography dataset with either FiberStars or an existing dMRI exploration tool. Our results show that participants using FiberStars can navigate extensive collections of tractography faster and more accurately. All our research, software, and results are available openly.
description: 10 pages, 9 figures
Optimizing QKD efficiency by addressing chromatic dispersion and time measurement uncertainty
Creators: name: Czerwinski, Artur
name: Haddadi, Saeed
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In this paper, we present a Quantum Key Distribution (QKD) protocol that accounts for fundamental practical challenges, including chromatic dispersion, time measurement uncertainty, and dark counts. Our analysis provides a comprehensive framework for understanding the impact of these physical phenomena on QKD efficiency, offering practical strategies for enhancing the robustness and security of quantum communication systems in real-world applications. In particular, by manipulating the chirp parameter of single-photon wave packets, we demonstrate significant improvements in key generation rates and an extended range of secure communication.
Separating truth from lies: comparing the effects of news media literacy interventions and fact-checkers in response to political misinformation in the US and Netherlands
Creators: name: Hameleers, Michael
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Although previous research has offered important insights into the consequences of mis- and disinformation and the effectiveness of corrective information, we know markedly less about how different types of corrective information – news media literacy interventions and fact-checkers – can be combined to counter different forms of misinformation. Against this backdrop, this paper reports on experiments in the US and the Netherlands (N = 1,091) that exposed people to evidence-based or fact-free anti-immigration misinformation, fact-checkers and/or a media literacy intervention. The main findings indicate that evidence-based misinformation is seen as more accurate than fact-free misinformation, and the combination of news media literacy interventions and fact-checkers is most effective in lowering issue agreement and perceived accuracy of misinformation across countries. These findings have important implications for journalism practice and policy makers that aim to combat mis- and disinformation.
Actinocleidus fergusoni Mizelle 1938
Creators: name: Mendoza-Garfias, Berenit
name: García-Prieto, Luis
name: León, Gerardo Pérez-Ponce De
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Monogenea
Dactylogyridea
Dactylogyridae
Actinocleidus
Actinocleidus fergusoni

description: Actinocleidus fergusoni Mizelle, 1938
 Actinocleidus fergusoni Mizelle, 1938: 45.
HOSTS. — Actinopterygii (gills).
 GEOGRAPHIC DISTRIBUTION. — Hidalgo. Laguna de Atezca: Micropterus salmoides (Aguilar-Aguilar et al. 2004).
SPECIMENS IN COLLECTIONS. — None.
description: Published as part of Mendoza-Garfias, Berenit, García-Prieto, Luis & León, Gerardo Pérez-Ponce De, 2017, Checklist of the Monogenea (Platyhelminthes) parasitic in Mexican aquatic vertebrates, pp. 501-598 in Zoosystema 39 (4) on page 509, DOI: 10.5252/z2017n4a5, http://zenodo.org/record/4578694
Testing Option Pricing with the Edgeworth Expansion
Creators: name: Filho, Ruy Gabriel Balieiro
name: Rosenfeld, Rogerio
Publisher: name: arXiv
Year: 2004
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: There is a well developed framework, the Black-Scholes theory, for the pricing of contracts based on the future prices of certain assets, called options. This theory assumes that the probability distribution of the returns of the underlying asset is a gaussian distribution. However, it is observed in the market that this hypothesis is flawed, leading to the introduction of a fudge factor, the so-called volatility smile. Therefore, it would be interesting to explore extensions of the Black-Scholes theory to non-gaussian distributions. In this contribution we provide an explicit formula for the price of an option when the distributions of the returns of the underlying asset is parametrized by an Edgeworth expansion, which allows for the introduction of higher independent moments of the probability distribution, namely skewness and kurtosis. We test our formula with options in the brazilian and american markets, showing that the volatility smile can be reduced. We also check whether our approach leads to more efficient hedging strategies of these instruments.
description: 9 pages, 3 figure. Contribution to the International Workshop on Trends and Perspectives on Extensive and Non-Extensive Statistical Mechanics, November 19-21, 2003, Angra dos Reis, Brazil