cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Geriatric Radiology – Challenges and Opportunities
Creators: name: Scheffler, Max
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/616.0757

description:
In the light of an ongoing demographic change in Switzerland, an increasing quantity of radiologic exams is performed in older people. The Trois-Chêne Hospital in Thônex, Switzerland, is a 300-bed hospital dedicated to geriatric patients and disposes since 2014 of a fully equipped radiological platform with computed tomography (CT) and magnetic resonance imaging (MRI) machines, in addition to conventional radiography and ultrasound equipment. A great number of routine exams can now be performed on site without having to transfer patients to the main hospital site of Geneva University Hospitals, about seven kilometers away, thus avoiding stress and costs. Steps have been taken to adapt procedures for performing imaging studies in older patients, considering specific limitations and needs. Following a short review on the coronavirus disease 2019 (COVID-19) pandemic's impact on the imaging site, some of these steps are explained in this work, followed by the presentation of three areas of research the radiological section is involved in. Firstly, as dementing diseases are increasing in older age groups, often of the mixed type of Alzheimer's disease and vascular dementia, the radiological section participated in a radiologic-histopathologic correlation study aiming to gain knowledge about lesser known biomarkers associated with cognitive disorders of vascular origin – cerebral microbleeds and cortical microinfarcts – and two of the studies performed are presented here (articles 1 and 2). Secondly, chronic back pain-associated sciatica is a common condition in older patients, and treatment options include minimally invasive nerve root infiltrations. Sometimes these are performed repeatedly in the same patient, as the effects may wean off after some time, and we optimized procedural steps in the radiological section to perform them under MRI guidance – allowing for high contrast resolution and preferable in situations where radioprotection might be a concern or in patients that are allergic to iodine. Article 3 treats this subject. Thirdly and finally, pneumonia is a common and – even in the pre- COVID-19 era – devastating disease in older patients, and we were interested in the role CT should assume in the diagnostic process, as opposed to conventional radiographs. Two articles we published on a retrospective interventional study on this subject (articles 4 and 5) are presented in this work. The conclusion section finally offers a future outlook on the three treated fields – dementia, minimally invasive pain therapy, and improvement in the diagnosis of pneumonia in older patients - with a short presentation of already planned or envisaged research projects.
MOESM2 of Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma
Creators: name: Li, Jun
name: Tan, Wenle
name: Peng, Linna
name: Zhang, Jialiang
name: Huang, Xudong
name: Cui, Qionghua
name: Zheng, Jian
name: Tan, Wen
name: Wu, Chen
name: Lin, Dongxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 2: Table S2. Short interfering RNA (siRNA) sequences used in this study.
Synthesis of 2-pyridylthiophosphinic acids and 2-pyridylthiophosphonate monoesters via nucleophilic aromatic substitution
Creators: name: Natsuhisa Oka
name: Ori, Kensuke
name: Ando, Kaori
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: Hematology

description: In this study, we developed a method for the synthesis of 2-pyridylthiophosphinic acids and 2-pyridylthiophosphonate monoesters using easily accessible starting materials, H-phosphinate and H-phosphonate esters and pyridine N-oxides. The H-phosphinate and H-phosphonate esters were sulfurized to give H-thiophosphinate and H-thiophosphonate esters. The pyridine N-oxides were converted into N-methoxypyridinium sulfonates, which were then used for nucleophilic aromatic substitution with the H-thiophosphinate/thiophosphonate esters to afford 2-pyridylthiophosphinate monoesters and 2-pyridylthiophosphonate diesters. Finally, alkaline hydrolysis and subsequent neutralization afforded various 2-pyridylthiophosphinic acids and 2-pyridylthiophosphonate monoesters in good yields. The structure of a 2-pyridylthiophosphonate monoester was determined using X-ray crystallographic analysis.
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2
Creators: name: Hotop, Sven-Kevin
name: Reimering, Susanne
name: Shekhar, Aditya
name: Asgari, Ehsaneddin
name: Beutling, Ulrike
name: Dahlke, Christine
name: Fathi, Anahita
name: Khan, Fawad
name: Lütgehetmann, Marc
name: Ballmann, Rico
name: Gerstner, Andreas
name: Tegge, Werner
name: Cicin-Sain, Luka
name: Bilitewski, Ursula
name: McHardy, Alice C.
name: Brönstrup, Mark
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The coronavirus SARS-CoV-2 is the causative agent for the disease COVID-19. To capture the IgA, IgG and IgM antibody response of patients infected with SARS-CoV-2 at individual epitope resolution, we constructed planar microarrays of 648 overlapping peptides that cover the four major structural proteins S(pike), N(ucleocapsid), M(embrane) and E(nvelope). The arrays were incubated with sera of 67 SARS-CoV-2 positive and 22 negative control samples. Specific responses to SARS-CoV-2 were detectable, and nine peptides were associated with a more severe course of the disease. A random forest model disclosed that antibody binding to 21 peptides, mostly localized in the S protein, was associated with higher neutralization values in cellular anti-SARS-CoV-2 assays. For antibodies addressing the N-terminus of M, or peptides close to the fusion region of S, protective effects were proven by antibody depletion and neutralization assays. The study pinpoints unsual viral binding epitopes that might be suited as vaccine candidates.
Palliative care integration in advanced chronic obstructive pulmonary disease: are we ready?
Creators: name: Fusi-Schmidhauser, Tanja
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/618.97

description:
Background: Chronic obstructive pulmonary disease (COPD) is a life-limiting condition with intrinsic unpredictability and developing palliative care needs along the disease trajectory. Despite increasing evidence about the important role that palliative care plays in care delivery for patients with advanced COPD, its accessibility and integration remain underdeveloped. Several factors influence the development of integrated care initiatives for patients with advanced COPD, such as misconceptions about palliative care and different modalities of care provision.

Aim: To identify, retrieve and summarise the available body of knowledge on palliative care integration in advanced COPD.

Methods: A narrative literature review was conducted following pre-defined quality criteria for this type of literature review. Six electronic databases were searched using a comprehensive search strategy to identify studies on palliative care integration in advanced COPD, published from January 1, 1960 to October 31, 2021.

Results: Twenty-six studies were included in the literature review. Of these papers, 12 adopted a qualitative approach, 12 adopted a quantitative approach and two were mixed-methods studies. Different aspects of integrated palliative care were considered in these papers, such as accessibility to care integration, patients', informal caregivers' and healthcare professionals' perceptions and experiences on integrated care initiatives, clinical and non-clinical outcomes of integrated care initiatives and development of new conceptual models for integrated care delivery.

Conclusion: This narrative literature review highlighted several key aspects of palliative care integration in advanced COPD, such as promoting accessibility through identification of patients' needs, improving communication between healthcare providers and with patients and their families, and fostering effective advance care planning and coordination of services. Further research is needed to encourage a broader understanding of the challenges that are related to palliative care integration in advanced COPD and to support the development of new integrated care initiative in all settings.
Association between depressive symptoms and morningness-eveningness, sleep duration and rotating shift work in Japanese nurses
Creators: name: Fumiharu Togo
name: Yoshizaki, Takahiro
name: Komatsu, Taiki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Higher depressive symptoms have been reported in rotating shift workers compared with day workers. Depressive symptoms in adults who do not engage in night work have also been shown to be associated with chronotype and sleep duration. This study examines associations between depressive symptoms, morningness-eveningness (i.e. the degree to which people prefer to be active in the morning or the evening), sleep duration and rotating shift work. Japanese nurses (1252 day workers and 1780 rotating shift workers, aged 20–59) were studied using a self-administered questionnaire. The questionnaire covered depressive symptoms, morningness-eveningness, sleep habits and demographic characteristics of the participants. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to determine the levels of depressive symptoms. A Japanese version of the Morningness-Eveningness Questionnaire (MEQ) was used to measure morningness-eveningness. The CES-D score of shift workers was significantly (p < 0.05) higher than that of day workers. The MEQ score was significantly (p < 0.05) lower (i.e. greater eveningness) in shift workers than in day workers. Sleep duration on the day shift was significantly (p < 0.05) shorter in shift workers than in day workers. Simple linear regression revealed that the MEQ score, sleep duration on the day shift and current work shift (i.e. rotating shift work) were significantly (p < 0.05) associated with the CES-D score. Multivariate linear regression indicated that greater eveningness and shorter sleep duration were independently associated with higher CES-D scores, while rotating shift work was not. These associations between the MEQ score, the sleep duration and the CES-D score were also confirmed in both day workers and shift workers when the groups were analyzed separately. These results suggest that greater eveningness and shorter sleep duration on the day shift were independently associated with higher levels of depressive symptoms, which may explain associations between rotating shift workers and depressive symptoms. These findings have important implications for the development of novel strategies for preventing poor mental health in day workers and rotating shift workers.
Generationenbeziehungen im Alter: Türkische Familien in der Türkei und in Westeuropa
Creators: name: Baykara-Krumme, Helen
Publisher: name: Journal of Family Research
Year: 2013

description: This paper explores the consequences of international migration on family relationships of elderly migrants from a new perspective: It compares intergenerational relationships among migrants from Turkey who live in Europe with those among non-migrants who never went abroad and, as a third group, transnational families. This study draws from the international LineUp Survey “Migration Histories of Turks in Europe”. Dependent variables are the frequency of contact, mutual support exchange patterns and family values as reported by the adult children. Findings indicate more intense intergenerational relationships in migrant families as compared to families in Turkey, but lower agreement with norms on intergenerational solidarity among the former. Whereas differences in behavior can be explained almost completely by compositional differences, multivariate analyses suggest persisting divergences in attitudes. Transnational families show the lowest degree of intergenerational solidarity which can be explained by the large spatial distance. By tendency, the findings indicate a change in values, but overall continuity in behavior patterns in the course of an international migration. Zusammenfassung Dieser Beitrag nähert sich der Frage nach den Auswirkungen einer internationalen Migration auf die Generationenbeziehungen älterer Menschen aus einer neuen Perspektive: Verglichen werden die Beziehungen in türkeistämmigen Familien in Westeuropa mit Familien in der Türkei sowie, als dritte Gruppe, transnationalen Familien. Die Datengrundlage bildet die internationale LineUp- Studie „Migration Histories of Turks in Europe“. Zielvariablen sind familienbezogene Werteinstellungen sowie Kontakthäufigkeit und gegenseitige Unterstützungsleistungen aus Sicht der erwachsenen Kinder. Migrantenfamilien zeigen in den Verhaltensmustern intensivere Beziehungen als Familien in der Türkei, allerdings stellen diese Unterschiede nahezu vollständig Kompositionseffekte dar. Unterschiede in den Werteeinstellungen, mit geringerer normativer Solidarität in Migrantenfamilien, bleiben dagegen auch in multivariaten Analysen tendenziell bestehen. Transnationale Familien weisen die geringste Generationensolidarität auf, was auf die große Wohnentfernung zurückzuführen ist. Die Befunde geben tendenziell Hinweise auf einen Wertewandel in der Migration bei weitgehender Kontinuität der Verhaltensmuster.
description: Journal of Family Research, Vol 25 No 1 (2013): Türkische Familien in Deutschland
Einstellungen zur familialen Solidarität im Alter: Eine vergleichende Analyse mit türkischen Migranten und Deutschen
Creators: name: Carnein, Marie
name: Baykara-Krumme, Helen
Publisher: name: Journal of Family Research
Year: 2013

description: The study examines the attitudes toward family solidarity and filial care obligations among Turks of the first and second immigrant generation as compared to Germans. The focilie on the impact of ethnic-cultural and socio-structural predictors, respectively, and whether patterns change across different age groups. Processes of intergenerational transmission and acculturation in migration constitute the theoretical background. Data from the Generations and Gender Survey 2005 and 2006 are used, including respondents in private households in Germany aged 18 to 79 years of the main sample, and the migrant sample, conducted on same-aged Turkish citizens in Germany. It was found that the family solidarity potential is far higher among Turkish migrants than among Germans. These differences persist in the second generation and in all age groups. Socio-structural predictors are of little relevance. The analyses indicate strong transmission processes between family generations: There ist little evidence of an “acculturation gap”. Zusammenfassung Die Studie untersucht das familiale Solidaritätspotenzial für pflegebedürftige Eltern bei türkischen Migranten der ersten und zweiten Generation und kontrastiert es mit jenem der deutschen einheimischen Bevölkerung. Die zentralen Fragen lauten, welche Rolle ethnisch-kulturellen bzw. sozialstrukturellen Einflussgrößen zukommt und ob sich die Muster über verschiedene Altersgruppen hinweg verändern. Den theoretischen Hintergrund bilden Diskussionen um Transmissions- und Akkulturationsprozesse in der Migration. Auf Grundlage der Daten des Generations and Gender Survey 2005 und 2006, der die 18 bis 79-jährige Wohnbevölkerung in Privathaushalten Deutschlands sowie in einer Zusatzerhebung ergänzend die türkischen Staatsangehörigen berücksichtigt, kann gezeigt werden, dass das familiale Solidaritätspotenzial bei türkischen Migranten wesentlich stärker ausgeprägt ist als bei Deutschen. Die Unterschiede bleiben in der nachfolgenden Generation und über alle Altersgruppen hinweg bestehen. Sozialstrukturelle Merkmale sind von geringer Bedeutung. Die Befunde zeigen, wie stark die Transmissionsprozesse zwischen den Generationen sind: Es gibt wenig Hinweise auf einen intergenerationalen „acculturation gap“.
description: Journal of Family Research, Vol 25 No 1 (2013): Türkische Familien in Deutschland
MOESM3 of Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma
Creators: name: Li, Jun
name: Tan, Wenle
name: Peng, Linna
name: Zhang, Jialiang
name: Huang, Xudong
name: Cui, Qionghua
name: Zheng, Jian
name: Tan, Wen
name: Wu, Chen
name: Lin, Dongxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Table S3. Primers used for real-time PCR in this study.
Digital health in Pediatric Emergency Medicine
Creators: name: Siebert, Johan
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/618
Digital health
Pediatric emrgency medicine
Pediatrics
Information technologies
Children
m-Health
e-Health

description:
Recent advances in digital technologies over the past two decades have created unparalleled opportunities to positively transform the medical sector, such as web platforms, mobile devices and smart wearables (known as the “Internet of Things”), artificial intelligence and big data analytics. Digital health offers the prospect of new diagnostic and therapeutic tools and services for better, safer, patient-centered and more easily accessible care, including at a distance, while better informing and empowering patients, and reducing costs. However, the advent of technology also brings its own set of challenges that must be addressed.

While many fields of medicine have rapidly embraced recent advances in digital health and are devoting a significant amount of resources to it for research and development, pediatric emergency medicine is still struggling to harness the considerable opportunities presented by digital health. At present, much of digital health used in pediatrics is off-label, relying on repurposed adult technologies that may not meet children's unique needs and supported by little or no evidence in this population.

This thesis outlines the author's research focus by presenting some of his contributions to the development and evaluation of digital health services and tools tailored for pediatric emergency medicine. The first study describes an interoperable digital health information system aimed at empowering patients throughout their journey to the pediatric emergency department and enabling the latter to anticipate their arrival, facilitate their visit, and enhance their follow-up. The next two trials focus on the trial-and-error development of a digital tool and its evaluation to increase adherence to pediatric cardiopulmonary resuscitation algorithms. Finally, the last two trials are part of an evaluation of a mobile application (app) to reduce pediatric medication errors, which began with an initial pilot study and expanded nationally to both a large-scale multicenter study in the hospital setting and another in the distinctly different prehospital setting. The thesis also aims to situate these projects in both a historical and current context, followed by a discussion of how they open up new and exciting perspectives in the pediatric field.
Erwerbsbeteiligung und Einstellungen zur Familie von türkischen Migrantinnen im Generationenvergleich
Creators: name: Milewski, Nadja
Publisher: name: Journal of Family Research
Year: 2013

description: The extent of labour force participation of women with a Turkish migration background in Germany is lower than that of women of other ethnic origins or that of non-migrant women. In this study, we focus on a within-group comparison of the labour force participation among Turkish women. Using data of the Generations and Gender Survey (2005/ 2006), we distinguish between first and second immigrant generations. The study pays special attention to both the human and social capital approach and aspects of intergenerational transmission and solidarity between generations. In line with the human capital theory, a strong increase in labour force participation can be noted among women belonging to the second migrant generation: Whereas only about 34 per cent of first generation immigrants participate in the workforce, the share among the second generation amounts to about 60 per cent. In addition to family status and education, mothers’ employment is found to increase the likelihood of the daughter’s participation in the workforce. Also, more egalitarian gender role attitudes favour a higher degree of employment. Zusammenfassung Die Arbeitsmarktbeteiligung von Frauen mit türkischem Migrationshintergrund in Deutschland ist geringer als die anderer Migrantengruppen und als die von Frauen ohne Migrationshintergrund. Diese Studie untersucht mit Daten des Generations and Gender Survey (2005/2006), inwiefern sich Frauen der ersten und zweiten Migrantengenerationen hinsichtlich ihrer Erwerbsbeteiligung unterscheiden und welche Faktoren dafür ursächlich sind. In Einklang mit der Humankapitaltheorie lässt sich für die zweite Generation eine stark gesteigerte Erwerbsbeteiligung feststellen: Während in der ersten Generation nur etwa 34 Prozent der Frauen einer Beschäftigung nachgehen, beteiligen sich rund 63 Prozent in der zweiten Generation am Arbeitsmarkt. Besondere Berücksichtigung erfährt der Sozialkapitalansatz bzw. Aspekte intergenerationaler Transmission und Solidarität. Demnach übt – neben Bildung und Familienstand ? eine Erwerbstätigkeit der Mutter einen Einfluss auf die Erwerbsbeteiligung der Tochter aus, und stärker egalitäre Genderrolleneinstellungen begünstigen eine Erwerbstätigkeit.
description: Journal of Family Research, Vol 25 No 1 (2013): Türkische Familien in Deutschland
Design-Based Maps for Finite Populations of Spatial Units
Creators: name: L. Fattorini
name: M. Marcheselli
name: L. Pratelli
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology
subject: Cardiology

description: The estimation of the values of a survey variable in finite populations of spatial units is considered for making maps when samples of spatial units are selected by probabilistic sampling schemes. The single values are estimated by means of an inverse distance weighting predictor. The design-based asymptotic properties of the resulting maps, referred to as the design-based maps, are considered when the study area remains fixed and the sizes of the spatial units tend to zero. Conditions ensuring design-based asymptotic unbiasedness and consistency are derived. They essentially require the existence of a pointwise or uniformly continuous density function of the survey variable onto the study area, some regularities in the size and shape of the units and the use of spatially balanced designs to select units. The continuity assumption can be relaxed into a Riemann integrability assumption when estimation is performed at a sufficiently small spatial grain and the estimates are subsequently aggregated at a greater grain. A computationally simple mean squared error estimator is proposed. A simulation study is performed to assess the theoretical results. An application to estimate the map of wine cultivations in Tuscany (Central Italy) is considered.
Unter welchen Bedingungen bekommen Eltern weitere Kinder? Ein Vergleich zwischen Deutschen und Türken unter besonderer Berücksichtigung ökonomischer Abwägungen
Creators: name: Naderi, Robert
Publisher: name: Journal of Family Research
Year: 2013

description: The article examines the question of how the selfreported financial situation has an effect on the actual birth of additional children in regard to generational support and migration background. The hypotheses to be tested are based on economic theories and research on the importance of economic uncertainty for fertility. Based on multivariate analyses of the two waves of the German Generations and Gender Survey, neither the individual financial situation, nor the relations between generations can be detected as effects on family expansion. The results show, however, that Turkish citizens differ in their migration experience in comparison to those who have immigrated in childhood or were born in Germany in terms of the explanatory factors. Factors like age of the woman, number and age of children are crucial in all groups under study. Zusammenfassung Im Beitrag wird der Frage nachgegangen, wie sich die selbsteingeschätzte persönliche finanzielle Situation auf die tatsächliche Geburt weiterer Kinder, unter Berücksichtigung generationaler Unterstützungspotenziale und dem Migrationshintergrund, auswirkt. Die zu überprüfenden Hypothesen basieren auf der ökonomischen Theorie und dem Forschungsstand zur Bedeutung ökonomischer Unsicherheiten für Fertilität. Mittels multivariater Analysen der zwei Wellen des deutschen Generations and Gender Survey, können weder Effekte der individuellen finanziellen Lage, noch der Generationenbeziehungen auf die Familienerweiterung nachgewiesen werden. Die Ergebnisse zeigen hingegen, dass sich türkische Staatsbürger mit eigener Migrationserfahrung von denen, die im Kindesalter immigriert sind bzw. in Deutschland geboren wurden, bezüglich der Erklärungsfaktoren unterscheiden. In allen drei Gruppen sind Faktoren wie das Alter der Frau, die Kinderzahl und das Alter der Kinder für die Familienerweiterung zentral.
description: Journal of Family Research, Vol 25 No 1 (2013): Türkische Familien in Deutschland
MOESM4 of Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma
Creators: name: Li, Jun
name: Tan, Wenle
name: Peng, Linna
name: Zhang, Jialiang
name: Huang, Xudong
name: Cui, Qionghua
name: Zheng, Jian
name: Tan, Wen
name: Wu, Chen
name: Lin, Dongxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 4: Table S4. Pancreatic cancer microarray datasets included in the study.
Phegea53-2. Filatima incomptella (Lepidoptera: Gelechiidae: Gelechiini), nieuw voor de Belgische fauna
Creators: name: Steeman, Chris
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310913
subject: Invertebrate biology

description: On September 9, 2023, Filatima incomptella (Herrich-Schäffer, 1854) (Gelechiidae) was captured at a light trap in the Brackvenn in the High Fens national nature reserve near Eupen (province of Liège). This species is mentioned here for the first time for the Belgian fauna.
Intrinsic energy flow in laser-excited 3d ferromagnets
Creators: name: Zahn, Daniela
name: Jakobs, Florian
name: Seiler, Hélène
name: Butcher, Tim A.
name: Engel, Dieter
name: Vorberger, Jan
name: Atxitia, Unai
name: Windsor, Yoav William
name: Ernstorfer, Ralph
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Electron-phonon coupling
subject: Lattice dynamics
subject: Ultrafast magnetization dynamics
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Ultrafast magnetization dynamics are governed by energy flow between electronic, magnetic, and lattice degrees of freedom. A quantitative understanding of these dynamics must be based on a model that agrees with experimental results for all three subsystems. However, ultrafast dynamics of the lattice remain largely unexplored experimentally. Here we combine femtosecond electron diffraction experiments of the lattice dynamics with energy-conserving atomistic spin dynamics (ASD) simulations and ab initio calculations to study the intrinsic energy flow in the 3d ferromagnets cobalt (Co) and iron (Fe). The simulations yield a good description of experimental data, in particular an excellent description of our experimental results for the lattice dynamics. We find that the lattice dynamics are influenced significantly by the magnetization dynamics due to the energy cost of demagnetization. Our results highlight the role of the spin system as the dominant heat sink in the first hundreds of femtoseconds. Together with previous findings for nickel [Zahn et al., Phys. Rev. Research 3, 023032 (2021)], our work demonstrates that energy-conserving ASD simulations provide a general and consistent description of the laser-induced dynamics in all three elemental 3d ferromagnets.
The dissociative subtype of PTSD in trauma-exposed individuals: a latent class analysis and examination of clinical covariates
Creators: name: Deen, Aljosha
name: Biedermann, Sarah V.
name: Lotzin, Annett
name: Krüger-Gottschalk, Antje
name: Dyer, Anne
name: Knaevelsrud, Christine
name: Rau, Heinrich
name: Schellong, Julia
name: Ehring, Thomas
name: Schäfer, Ingo
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: PTSD
subject: dissociative subtype
subject: dissociation
subject: depression
subject: emotion regulation
subject: derealization
subject: depersonalization
subject: latent class analysis
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Background A dissociative subtype of posttraumatic stress disorder (D-PTSD) was introduced into the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) but latent profiles and clinical correlates of D-PTSD remain controversial. Objective The aims of our study were to identify subgroups of individuals with distinct patterns of PTSD symptoms, including dissociative symptoms, by means of latent class analyses (LCA), to compare these results with the categorization of D-PTSD vs. PTSD without dissociative features according to the CAPS-5 interview, and to explore whether D-PTSD is associated with higher PTSD severity, difficulties in emotion regulation, and depressive symptoms. Method A German sample of treatment-seeking individuals was investigated (N = 352). We conducted an LCA on the basis of symptoms of PTSD and dissociation as assessed by the CAPS-5. Moreover, severity of PTSD (PCL-5), difficulties in emotion regulation (DERS), and depressive symptoms (BDI-II) were compared between patients with D-PTSD according to the CAPS-5 interview and patients without dissociative symptoms. Results LCA results suggested a 5-class model with one subgroup showing the highest probability to fulfill criteria for the dissociative subtype and high scores on both BDI and DERS. Significantly higher scores on the DERS, BDI and PCL-5 were found in the D-PTSD group diagnosed with the CAPS-5 (n = 75; 35.7%). Sexual trauma was also reported more often by this subgroup. When comparing the dissociative subtype to the LCA results, only a partial overlap could be found. Conclusions Our findings suggest that patients with D-PTSD have significantly more problems with emotion regulation, more depressive symptoms, and more severe PTSD-symptoms. Given the results of our LCA, we conclude that the dissociative subtype seems to be more complex than D-PTSD as diagnosed by means of the CAPS-5.
Einführung in das Schwerpunktthema. Türkische Familien in Deutschland – Generationenbeziehungen und Generationenperspektiven
Creators: name: Milewski, Nadja
Publisher: name: Journal of Family Research
Year: 2013

description: -
description: Journal of Family Research, Vol 25 No 1 (2013): Türkische Familien in Deutschland
Specific IgE positivity against inhalant allergens and development of autoimmune disease
Creators: name: Skaaby, Tea
name: Husemoen, Lise Lotte Nystrup
name: Thuesen, Betina Heinsbæk
name: Fenger, Runa Vavia
name: Linneberg, Allan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background: Allergic and autoimmune diseases have been suggested to be inversely associated. We investigated the association between atopy and development of any and specific types of autoimmune disease. Methods: We included a total of 14 849 individuals from five population-based studies with measurements of atopy defined as specific IgE positivity against inhalant allergens. We followed the participants by linkage to the Danish National Patient Register (median follow-up time 11.2 years). Hazard ratio (HR) and 95% confidence interval (CI) of autoimmune disease were estimated by Cox regression. Results: The risk for atopics versus non-atopics was: for any autoimmune disease (HR = 0.99, 95% CI: 0.83, 1.18), thyrotoxicosis (HR = 0.69, 95% CI: 0.34, 1.37), type 1 diabetes (HR = 1.16, 95% CI: 0.84, 1.60), multiple sclerosis (HR = 1.97, 95% CI: 0.95, 4.11), iridocyclitis (HR = 0.82, 95% CI: 0.38, 1.74), Crohn’s disease (HR = 1.03, 95% CI: 0.47, 2.25), ulcerative colitis (HR = 0.93, 95% CI: 0.52, 1.69), psoriasis vulgaris (HR = 1.50, 95% CI: 0.86, 2.62), seropositive rheumatoid arthritis (HR = 0.74, 95% CI: 0.48, 1.14) and polymyalgia rheumatica (HR = 0.79, 95% CI: 0.44, 1.44). Conclusions: We found no statistically significant associations between atopy and autoimmune disease, but we cannot exclude relatively small to moderate effects - protective or promotive - of atopy on autoimmune disease.
MOESM1 of Microbial community and diversity in the feces of Sichuan takin (Budorcas taxicolor tibetana) as revealed by Illumina Miseq sequencing and quantitative real-time PCR
Creators: name: Zhu, Hui
name: Zeng, Dong
name: Wang, Ning
name: Niu, Li-li
name: Zhou, Yi
name: Zeng, Yan
name: Ni, Xue-qin
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Additional file 1: Table S1. Primers used for group-specific quantitative real-time PCR.
Contribution of autoallergy to the pathogenesis in the NOD mice
Creators: name: Thyagarajan, Radha
name: Viqar Banday
name: Zhoujie Ding
name: Lejon, Kristina
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The immunoglobulin isotype IgE is commonly associated with allergy. However, its involvement in autoimmune disease in general, and Type 1 diabetes (T1D) in particular, is still not completely clarified, nonetheless IgE has been observed in patients with T1D. In this article, we aimed to elucidate the contribution of IgE in the pathogenesis of the disease in a spontaneous model for T1D, i.e. the NOD mouse. We observed increased levels of IgE in splenic, lymph node and peripheral blood B cells in the NOD mice compared to the control C57BL/6 (B6) mice. No correlation was found between the IgE levels on B cells and those in the sera of these mice, indicating a B cell intrinsic property mediating IgE capture in NOD. Functionally, the B cells from NOD were similar to B6 in rescuing the IgE-mediated immune response via the low affinity receptor CD23 in a transgenic adoptive transfer system. However, the involvement of IgE in diabetes development was clearly demonstrated, as treatment with anti-IgE antibodies delayed the incidence of the diabetes in the NOD mice compared to the PBS treated group. Pancreas sections from a 13-week-old NOD revealed the presence of tertiary lymphoid structures with T cells, B cells, germinal centers and IgE suggesting the presence of autoantigen specific IgE. Our study provides an insight to the commonly overlooked immunoglobulin IgE and its potential role in autoimmunity.
Reactivation of persistent Epstein–Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface
Creators: name: Nagata, Keiko
name: Nakayama, Yuji
name: Higaki, Katsumi
name: Ochi, Marika
name: Kanai, Kyosuke
name: Matsushita, Michiko
name: Kuwamoto, Satoshi
name: Kato, Masako
name: Murakami, Ichiro
name: Iwasaki, Takeshi
name: Nanba, Eiji
name: Kimura, Hiroshi
name: Hayashi, Kazuhiko
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Epstein–Barr virus (EBV) is a ubiquitous virus that infects most adults latently. It persists in B lymphocytes and reactivates occasionally. Graves' disease is an autoimmune hyperthyroidism caused by thyrotropin receptor antibodies (TRAbs). We have reported that Graves' disease patients and healthy controls have EBV-infected lymphocytes that have TRAbs on their surface (TRAb(+)EBV(+) cells) in peripheral blood mononuclear cells (PBMCs). EBV reactivation is known to be associated with plasma cell differentiation and antibody production of B cells. In this study, we investigated whether TRAb(+)EBV(+) cells really produce TRAbs or not when persistent EBV is reactivated. We cultured PBMCs from 12 Graves' disease patients and 12 healthy controls for several days with cyclosporine A to expand the EBV-infected cell population, and then compared TRAb levels between EBV reactivation by 33 °C culture and EBV nonreactivation by 37 °C culture of PBMCs. Flow cytometry confirmed that all samples at day 0 (reactivation starting point) contained TRAb(+)EBV(+) cells. During 33 °C culture, EBV-reactivated cells with EBV-gp350/220 expression increased from about 1 to 4%. We quantified TRAb levels in culture fluids by radio-receptor assay, and detected an increased concentration for at least one sampling point at 33 °C (from days 0 to 12) for all patients and healthy controls. TRAb levels were significantly higher in supernatants of 33 °C culture than of 37 °C culture, and also significantly higher in supernatants from patients than those from controls. This study revealed TRAb production from TRAb(+)EBV(+) cells in response to reactivation induction of persistent EBV in different efficiencies between patients and controls.
MOESM5 of Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma
Creators: name: Li, Jun
name: Tan, Wenle
name: Peng, Linna
name: Zhang, Jialiang
name: Huang, Xudong
name: Cui, Qionghua
name: Zheng, Jian
name: Tan, Wen
name: Wu, Chen
name: Lin, Dongxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 5: Table S5. Hazard ratio (HR) of death for genes in the pathway in cancer that are differentially expressed in pancreatic cancer, based on data in two databases.
Interaction between lipid droplets and endoplasmic reticulum in human atherosclerotic plaques
Creators: name: Perrotta, Ida
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Lipid droplets (LDs) are intracellular organelles that are found in nearly all cell types, where they serve fundamental roles in lipid metabolism and energy homeostasis. Traditionally considered as simple lipid storage deposits, these dynamic and remarkable organelles have recently been implicated in a number of other cellular functions, ranging from protein storage and degradation to virus replication. Intracellular accumulation of LDs is also a hallmark feature of diverse human diseases including diabetes type II, obesity, hepatosteatosis, cancer, and atherosclerosis. LDs are highly motile and possess the capability to interact with a variety of cell organelles, such as the endoplasmic reticulum membranes, mitochondria, endosomes, and peroxisomes. To date, however, much remains to be learned regarding the existence and structure of these interactions in the cardiovascular system. The results presented herein demonstrate that in the foam cells of human atherosclerotic plaques, LDs are preferentially associated with ER membranes probably to form a lipid-buffer system that allows the storage of free fatty acids and reduces the risk of lipotoxicity.
Additional file 2: of Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice
Creators: name: Zhang, Jing
name: Malo, Danielle
name: Mott, Richard
name: Panthier, Jean-Jacques
name: Montagutelli, Xavier
name: Jaubert, Jean
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. QTLs associated with bacterial loads in spleen after S. Typhimurium infection in different subsets of CC strains. X-axis: genome location of each QTL Stls1 and Stls2 identified in Fig. 2; Y-axis: probability of detecting QTLs at different genomic significance (E < 0.5 in gray, E < 0.1 in orange, E < 0.05 in red and combined in blue). Genome-wide thresholds of association at E < 0.5, E < 0.1 and E < 0.05 significance levels of each test were determined by 200 permutation tests. Subsets of 15, 20, 25, 30 and 34 CC strains were tested. Within each subset, 500 random permutations were tested, except for subset of 34 CC, with only 35 possible permutations. (PDF 66 kb)
MOESM6 of Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma
Creators: name: Li, Jun
name: Tan, Wenle
name: Peng, Linna
name: Zhang, Jialiang
name: Huang, Xudong
name: Cui, Qionghua
name: Zheng, Jian
name: Tan, Wen
name: Wu, Chen
name: Lin, Dongxin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 6: Table S6. Genes associated with CKS2 expression level in pancreatic cancer tissues, based on data in The Cancer Genome Atlas.
Efficacy and safety of intravitreal dexamethasone implant (Ozurdex®) in real-life practice
Creators: name: Malcles, Ariane
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/616.8
Œdème maculaire
Dexamethasone
Traitement

description:
Millions of patients worldwide suffer from macular edema and associated loss of visual acuity. Luckily, the range of available treatments has widened over the past few years including the dexamethasone sustained-release implant (Ozurdex®) - a biodegradable intravitreal implant that maintains a high concentration of corticosteroids in the vitreous for up to 3 - 4 months. This progressive release decreases treatment burden compared to anti-VEGF that often require monthly injections.

We present the results of 3 real-life studies investigating the effects of Ozurdex® in diabetic macular edema (RELDEX study), non-infectious uveitis (RUVDEX study) and persistent postsurgical macular edema (EPISODIC 2 study).

A known side effect of steroids is ocular hypertension. Real-life studies SAFODEX 1 and 2 report new data on pressure tolerance of Ozurdex® and identify risk factors for ocular hypertension after dexamethasone implant offering scientific proof for better patient selection and follow-up.