cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Contrast enhanced ultrasonography is safe in paediatric patients: a 10-year retrospective study
Creators: name: Torres, Alvaro
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Contrast agents
subject: Liver
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Transplantation
subject: Metastases
subject: Haemodynamics / Flow dynamics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Contrast enhanced ultrasound (CEUS) is valuable in adults. However, it is not licensed for children <18 years, but off-label use is known to occur. We have used CEUS in children for the last decade in specific diagnostic questions. Our aim was to...
Universality in higher order spin noise spectroscopy
Creators: name: Li, Fuxiang
name: Sinitsyn, N. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Higher order time-correlators of spontaneous spin fluctuations reveal the information about spin interactions. We argue that in a broad class of spin systems one can justify a phenomenological approach to explore such correlators. Thus, we predict that the 3rd and 4th order spin cumulants are described by a universal function that can be parametrized by a small set of parameters. We show that the fluctuation theorem constrains this function so that such correlators are fully determined by lowest nonlinear corrections to the free energy and the mean and variance of microscopic spin currents. We also provide an example of microscopic calculations for conduction electrons.
description: 5 pages with supplementary materials, 2 Figs
Dynamic Programming Methods for Characterizing In-Season Farm Management Decisions
Creators: name: Gallagher, Nicholas James
Publisher: name: Unknown
Year: 2024
Subjects: subject: Crop Production/Industries
subject: Environmental Economics and Policy
subject: agriculture industry
subject: agricultural production system
subject: computing sequential decision-making models
subject: environment

description: The agriculture industry is unique in the high level of influence from randomness in the environment due to the many ways in which an agricultural production system interacts with the environment. Static models fail to accurately characterize the sequential decision process of the farmer. Capturing the temporal dynamics of farm management decisions necessitates a sequential decision model. The demands of conceptualizing and computing sequential decisionmaking models are especially salient in agriculture, where substantial influence from countless exogenous random variables has made useful formulations of many farm-level decisions intractable. I begin with an assessment of decision making in agriculture, focusing on the potential of sequential decision models, and provide a brief history of their applications in farmlevel decision making. I then present a generalized model of in-season crop production that ties all field level decisions to the temporal constraint inherent to a single production season. I discuss the considerations necessary to effectively model farm-level decision making with a dynamic model, and additional considerations for possible extensions of the model. I then present three applications of the model. The first application is to a simplified crop decision problem where a farmer is deciding the allocation of acres between corn and soybeans. The second application is to the prevented planting policy of Revenue Protection crop insurance. The third application is to a short-horizon alfalfa harvest optimization problem.
title: The role of diffusion tensor imaging (DTI) in developmental brain anomalies in pediatric age group of Egyptian patients
Creators: name: Haroun, Dina
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: CNS
subject: Paediatric
subject: MR-Diffusion/Perfusion
subject: Computer Applications-3D
subject: Imaging sequences
subject: Congenital
subject: Developmental disease
subject: Metabolic disorders

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The developmental brain anomalies are commonly encountered in day to day practice, it is very important for every radiologist to be familiar with the basic imaging findings of common anomalies to make correct diagnosis necessary for optimum...
title: Characteristics of interval cancers after adding 3D automated breast ultrasound (ABUS) to a service screening programme
Creators: name: Wilczek, Brigitte
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Ultrasound physics
subject: Ultrasound
subject: Screening
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To describe the characteristics of interval cancers after adding 3D Automated Breast Ultrasound (ABUS) ( Fig. 1 )to a service screening...
Replication of Worst-Motive Fallacy at BYUI in Winter 2021
Creators: name: Trautman, Cody
name: Hubbard, Jordyn
name: Johns, Colin
name: Bradbury, Holly
name: Wiggins, Bradford
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: This is a replication of the "Worst Motive Original" study. In that study they were exploring if people had a tendency to assume people's actions were done out of the worst motives that they had. They conducted the study by presenting several vignettes display two motivations that include two different actions and recording their responses along with what they thought they would choose. It was found that the participants thought the protagonist would pick the worst option that they felt the protagonist would do.
title: Influence of X-ray energy spectrum in the post-reconstruction method for beam hardening correction in polyenergetic CT reconstruction
Creators: name: Yang, Bin
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Radiation physics
subject: Computer applications
subject: CT
subject: Physics
subject: Computer Applications-Virtual imaging
subject: Technical aspects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Beam hardening artifacts are common in X-ray computed tomography and are mainly caused by the polyenergetic spectrum of X-ray source. Post-reconstruction method is one of the widely used algorithms for reducing the beam harending artifacts. While...
MPEC 2024-R123 : 2019 EY8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2019 EY8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
Creators: name: Jarvis, Marc A.
name: Yanishevski, David
name: Brown, Nicholas G.
name: Miller, Darcie J.
name: Schulman, Brenda A.
name: Yamaguchi, Masaya
name: Harper, J. Wade
name: Lu, Ying
name: Haselbach, David
name: Kuhlman, Brian
name: Yu, Shanshan
name: Sidhu, Sachdev S.
name: VanderLinden, Ryan
name: Qiao, Renping
name: Petzold, Georg
name: Weissmann, Florian
name: Brunner, Michael R.
name: Stark, Holger
name: Watson, Edmond R.
name: Kirschner, Marc W.
name: Peters, Jan-Michael
name: Davidson, Iain F.
name: Harrison, Joseph S.
name: Mercredi, Peter Y.
name: Grace, Christy R.R.
name: Zhang, Wei
name: Dube, Prakash
name: Wu, Kuen-Phon
name: Ordureau, Alban
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Protein ubiquitination involves E1, E2, and E3 trienzyme cascades. E2 and RING E3 enzymes often collaborate to first prime a substrate with a single ubiquitin (UB) and then achieve different forms of polyubiquitination: multiubiquitination of several sites and elongation of linkage-specific UB chains. Here, cryo-EM and biochemistry show that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two partner E2s, UBE2C (aka UBCH10) and UBE2S, adopt specialized catalytic architectures for these two distinct forms of polyubiquitination. The APC/C RING constrains UBE2C proximal to a substrate and simultaneously binds a substrate-linked UB to drive processive multiubiquitination. Alternatively, during UB chain elongation, the RING does not bind UBE2S but rather lures an evolving substrate-linked UB to UBE2S positioned through a cullin interaction to generate a Lys11-linked chain. Our findings define mechanisms of APC/C regulation, and establish principles by which specialized E3-E2-substrate-UB architectures control different forms of polyubiquitination.
title: Increasing the diagnostic performance of automated breast ultrasound by reducing breathing artifacts
Creators: name: de Korte, Chris
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Ultrasound physics
subject: Ultrasound
subject: Image manipulation / Reconstruction
subject: Screening
subject: Physics
subject: Artifacts
subject: Cancer
subject: Cysts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Automated Breast Volume Scanning (ABVS) is a user-independent 3-D ultrasound (US) method developed for breast cancer screening with similar sensitivity and specificity to hand-held US [1,2]. It has a high potential for screening patients with dense...
title: Diffusion-weighted imaging and MR-perfusion in different acute stroke subtypes
Creators: name: Suslin, Alexander
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Acute
subject: Ischaemia / Infarction
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of our study was to evaluate magnetic resonance diffusion and perfusion characteristics of the brain tissue in different pathogenetic subtypes of acute stoke in the territory of the middle cerebral...
MPEC 2024-R124 : 2019 EZ8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2019 EZ8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Creators: name: Li, Lin
name: Org, Elin
name: Didonato, Joseph A.
name: Sartor, R. Balfour
name: Tang, W.H. Wilson
name: Silverstein, Roy L.
name: Fu, Xiaoming
name: Zhu, Weifei
name: Gupta, Nilaksh
name: Gregory, Jill C.
name: Brown, J. Mark
name: Lusis, Aldons J.
name: Hazen, Stanley L.
name: Mehrabian, Margarete
name: McIntyre, Thomas M.
name: Wang, Zeneng
name: Buffa, Jennifer A.
name: Wu, Yuping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Normal platelet function is critical to blood hemostasis and maintenance of a closed circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic diseases and enhanced potential for thrombotic events. We now show gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential. Plasma TMAO levels in subjects (N>4000) independently predicted incident (3 yr) thrombosis (heart attack, stroke) risk. Direct exposure of platelets to TMAO enhanced submaximal stimulus-dependent platelet activation from multiple agonists through augmented Ca2+ release from intracellular stores. Animal model studies employing dietary choline or TMAO, germ-free mice, and microbial transplantation, collectively confirm a role for gut microbiota and TMAO in modulating platelet hyperresponsiveness and thrombosis potential, and identify microbial taxa associated with plasma TMAO and thrombosis potential. Collectively, the present results reveal a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thrombosis risk.
Electromagnetic form factors in the Hypercentral Constituent Quark Model
Creators: name: De Sanctis, M.
name: Giannini, M. M.
name: Santopinto, E.
name: Vassallo, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss the recent experimental results on the ratio bertween the electric and magnetic proton form factors and how they can be described by the hypercentral Constituent Quark Model.
Troy, Ford, McRae, Zarolia, & Mauss (2017) Replication at IIT Spring 2021
Creators: name: Legate, Nicole
name: Bullock, Alexandra
name: Parro, Sarah
name: Rodriguez, Yunuen
name: Hamilton, Jack
name: Galvan, Michael
name: Duda, Evan
name: Shack, Ana
name: Habercoss, Phallyn
name: Stoyanova, Nadia
name: Oziemkowski, Rebecca
name: Bastea, Allan
name: Moton, Deriniece
name: Dani, Aseem
name: Hildebrandt, Lea
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: CREP
subject: Illinois Tech
subject: Lewis College

description: We have just received approval for data collection from the CREP (our project is #21-19). No data has been collected or analyzed.
MC^2: Mapping the Dark Matter Distribution of the "Toothbrush" Cluster RX J0603.3+4214 with Hubble Space Telescope and Subaru Weak-lensing
Creators: name: Jee, M. James
name: Dawson, William A.
name: Stroe, Andra
name: Wittman, David
name: Van Weeren, Reinout J.
name: Bruggen, Marcus
name: Bradac, Marusa
name: Rottgering, Huub
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The galaxy cluster RX J0603.3+4214 at z=0.225 is one of the rarest clusters boasting an extremely large (~2 Mpc) radio-relic. Because of the remarkable morphology of the relic, the cluster is nicknamed "Toothbrush Cluster". Although the cluster's underlying mass distribution is one of the critical pieces of information needed to reconstruct the merger scenario responsible for the puzzling radio-relic morphology, its proximity to the Galactic plane b~10 deg has imposed significant observational challenges. We present a high-resolution weak-lensing study of the cluster with Subaru/Suprime Cam and Hubble Space Telescope imaging data. Our mass reconstruction reveals that the cluster is comprised of complicated dark matter substructures closely tracing the galaxy distribution, however in contrast with the relatively simple binary X-ray morphology. Nevertheless, we find that the cluster mass is still dominated by the two most massive clumps aligned north-south with a ~3:1 mass ratio (M_{200}=6.29_{-1.62}^{+2.24} x 10^{14} Msun and 1.98_{-0.74}^{+1.24} x 10^{14} Msun for the northern and southern clumps, respectively). The southern mass peak is ~2' offset toward the south with respect to the corresponding X-ray peak, which has a "bullet"-like morphology pointing south. Comparison of the current weak-lensing result with the X-ray, galaxy, and radio-relic suggests that perhaps the dominant mechanism responsible for the observed relic may be a high-speed collision of the two most massive subclusters, although the peculiarity of the morphology necessitates involvement of additional sub-clusters. Careful numerical simulations should follow in order to obtain more complete understanding of the merger scenario utilizing all existing observations.
description: Matched to the published version in ApJ
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
Creators: name: Woods, Elliot C.
name: Bergmeier, Wolfgang
name: Freeman, Spencer A.
name: Goyette, Jesse
name: Furuya, Wendy
name: Bertozzi, Carolyn R.
name: Hinz, Boris
name: Van Der Merwe, P. Anton
name: Das, Raibatak
name: Grinstein, Sergio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Phagocytosis is initiated by lateral clustering of receptors, which in turn activates Src-family kinases (SFKs). Activation of SFKs requires depletion of tyrosine phosphatases from the area of particle engagement. We investigated how the major phosphatase CD45 is excluded from contact sites, using single-molecule tracking. The mobility of CD45 increased markedly upon engagement of Fcγ receptors. While individual CD45 molecules moved randomly, they were displaced from the advancing phagocytic cup by an expanding diffusional barrier. By micropatterning IgG, the ligand of Fcγ receptors, we found that the barrier extended well beyond the perimeter of the receptor-ligand engagement zone. Second messengers generated by Fcγ receptors activated integrins, which formed an actin-tethered diffusion barrier that excluded CD45. The expanding integrin wave facilitates the “zippering” of Fcγ receptors onto the target and integrates the information from sparse receptor-ligand complexes, coordinating the progression and ultimate closure of the phagocytic cup.
title: 3-marker technique for the localisation and delineation of residual tumour bed following neoadjuvant chemotherapy in patients within the I-SPY 2 trial
Creators: name: Nelson, Michael
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Efficacy studies
subject: Biopsy
subject: Cancer
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast biopsy clips allow for the precise localization of biopsy-proven neoplastic breast lesions, minimizing the volume of breast tissue needed to be excised during the surgical removal of the tumor. 1 Already, clips have been shown to be useful in...
A systematic review and meta-analysis of the associaionts between non-paraphilic compulsive sexual behavior disorder (CSBD) and comorbid psychiatric disorders
Creators: name: Koós, Mónika
name: Bőthe, Beáta
name: Demetrovics, Zsolt
name: Nagy, Léna
name: Ünsal, Berk Can
name: Takacs, Zsofia
name: Kassai, Reka
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Clinical Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: comorbid psychiatric disorders
subject: compulsive sexual behavior
subject: hypersexuality
subject: meta-analysis
subject: sex addiction

description: The present meta-analysis aims to synthesize the available evidence regarding the association between non-paraphilic compulsive sexual behavior disorder (CSBD) and the comorbid psychiatric disorders. All psychiatric disorders will be examined listed in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013) in section III, and the 11th Revision of the International Classification of Diseases (ICD-11; World Health Organization, 2018) in chapter 6 (mental, behavioural or neurodevelopmental disorders).
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
Creators: name: Gerfen, Gary J.
name: Briggs, Kimberly J.
name: Witkiewicz, Agnieszka K.
name: Cao, Shugeng
name: Cravatt, Benjamin F.
name: Backus, Keriann M.
name: Zhang, Qing
name: Signoretti, Sabina
name: Clardy, Jon
name: Richardson, Andrea L.
name: Olenchock, Benjamin A.
name: Koivunen, Peppi
name: Kaelin, William G.
name: Patel, Hetalben
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The HIFα subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. We confirmed that TNBC cells secrete glutamate, which we found is both necessary and sufficient for the paracrine induction of HIF1α in such cells under normoxic conditions. Glutamate inhibits the xCT glutamate-cystine antiporter, leading to intracellular cysteine depletion. EglN1, the main HIFα prolyl-hydroxylase, undergoes oxidative self-inactivation in the absence of cysteine both in biochemical assays and in cells, resulting in HIF1α accumulation. Therefore, EglN1 senses both oxygen and cysteine.
title: Patient size and radiation dose: a grid too far?
Creators: name: Shur, Joshua
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Paediatric
subject: Radioprotection / Radiation dose
subject: Dosimetry
subject: Radiation safety
subject: Equipment

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Due to the wide variation in patient size with age, dose optimisation in paediatric patients performed with age alone is inadequate [1-4]. Despite recommendations that size should be considered in radiographic optimisation, sparse literature exists...
title: Vertebral artery diameter and flow: nature or nurture
Creators: name: Tarnoki, Adam
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Arteries / Aorta
subject: Cardiovascular system
subject: Vascular
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Ultrasound-Spectral Doppler
subject: Normal variants
subject: Screening
subject: Physiological studies
subject: Blood
subject: Epidemiology
subject: Haemodynamics / Flow dynamics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The vertebral arteries (VAs) are the primary blood supply for infratentorial brain structures, such as the posterior cortex, the cerebellum and the brainstem. VAs are smaller than the internal carotid artery, with a diameter ranging between 3 and 5...
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Creators: name: Schools, Zachary L.
name: Che, Tao
name: Shoichet, Brian K.
name: McCorvy, John D.
name: Dror, Ron O.
name: Levit, Anat
name: Nichols, David E.
name: Lansu, Katherine
name: Wang, Sheng
name: Venkatakrishnan,
name: Wacker, Daniel
name: Betz, Robin M.
name: Roth, Bryan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: SummaryThe prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety. LSD dissociates exceptionally slow from both 5-HT2BR and 5-HT2AR—a major target for its psychoactivity. Molecular dynamics (MD) simulations suggest that LSD's slow binding kinetics may be due to a "lid" formed by extracellular loop 2 (EL2) at the entrance to the binding pocket. A mutation predicted to increase the mobility of this lid greatly accelerates LSD's binding kinetics and selectively dampens LSD-mediated β-arrestin2 recruitment. This study thus reveals an unexpected binding mode of LSD; illuminates key features of its kinetics, stereochemistry, and signaling; and provides a molecular explanation for LSD's actions at human serotonin receptors.PaperClip
title: The challenge of B3 breast lesions at ultrasound-guided core needle biopsy: how to reduce the frequency of benign excision biopsies
Creators: name: Rella, Rossella
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Ultrasound
subject: Biopsy

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Percutaneous imaging-guided core needle biopsy (CNB) is a valid alternative to surgical biopsy for the diagnosis of suspicious breast lesions and it usually provides a definitive diagnosis [1, 2]. However, there are a number of histopathological...
Modeling Rett Syndrome Using TALEN-Edited  MECP2  Mutant Cynomolgus Monkeys
Creators: name: Yu, Juehua
name: Zhang, Kunshan
name: Hu, Xintian
name: Liu, Xiaojing
name: Huang, Shaoyong
name: Chen, Zhenzhen
name: Jiang, Tianzi
name: Luo, Yuping
name: Liu, Hailiang
name: Ji, Weizhi
name: Jiang, Yong
name: Li, Siguang
name: Niu, Yuyu
name: Zhang, Qingping
name: Lu, Yi
name: Chen, Yongchang
name: Wang, Jiaojian
name: Ma, Yuanye
name: Qin, Dongdong
name: Geng, Rui
name: Sun, Yi Eve
name: Si, Chenyang
name: He, Jing
name: Hu, Yingzhou
name: Li, Fuxing
name: Wei, Jingkuan
name: Wang, Shuang
name: Bao, Xinhua
name: Kang, Yu
name: Shen, Dinggang
name: Li, Gang
name: Liang, Aibin
name: Liu, Jie
name: Bai, Raoxian
name: Wu, Kunhua
name: Chen, Xiaoying
name: Wang, Junbang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental disorder, Rett syndrome (RTT), which is caused by loss-of-function mutations in the human MECP2 gene. Male mutant monkeys were embryonic lethal, reiterating that RTT is a disease of females. Through a battery of behavioral analyses, including primate-unique eye-tracking tests, in combination with brain imaging via MRI, we found a series of physiological, behavioral, and structural abnormalities resembling clinical manifestations of RTT. Moreover, blood transcriptome profiling revealed that mutant monkeys resembled RTT patients in immune gene dysregulation. Taken together, the stark similarity in phenotype and/or endophenotype between monkeys and patients suggested that gene-edited RTT founder monkeys would be of value for disease mechanistic studies as well as development of potential therapeutic interventions for RTT.
Analysis of Open Data and Computational Reproducibility in Registered Reports in Psychology
Creators: name: Obels, Pepijn
name: Lakens, Daniel
name: Coles, Nicholas
name: Gottfried, Jaroslav
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: data
subject: open data
subject: Psychology
subject: FOS: Psychology
subject: reproducibility
subject: RR

description: Ongoing technological developments have made it easier than ever before for scientists to share their data, materials, and analysis code. Sharing data and analysis code makes it easier for other researchers to re-use or check published research. These benefits will only emerge if researchers can reproduce the analysis reported in published articles, and if data is annotated well enough so that it is clear what all variables mean. Because most researchers have not been trained in computational reproducibility, it is important to evaluate current practices to identify practices that can be improved. We examined data and code sharing, as well as computational reproducibility of the main results, without contacting the original authors, for Registered Reports published in the in psychological literature between 2014 and 2018. Of the 62 articles that met our inclusion criteria, data was available for 40 articles, and analysis scripts for 37 articles. For the 35 articles that shared both data and code and performed analyses in SPSS, R, Python, MATLAB, or JASP, we could run the scripts for 31 articles, and reproduce the main results for 20 articles. Although the articles that shared both data and code (35 out of 62, or 56%) and articles that could be computationally reproduced (20 out of 35, or 57%) was relatively high compared to other studies, there is clear room for improvement. We provide practical recommendations based on our observations, and link to examples of good research practices in the papers we reproduced.
Factors Affecting Surgical Care-Seeking Behavior Among Rural Residents: A Scoping Review Protocol (Revision)
Creators: name: Zhang, Yuqi
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Rural Sociology
subject: Public Health
subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: Sociology
subject: FOS: Sociology
subject: Health Services Research
subject: Rural Bypass

description: This is a revised version of a previous protocol (https://osf.io/6ghzu). The proposed research will build on the understanding of factors influencing surgical care-seeking behavior among rural residents. Systematically analyzing the literature on surgical care-seeking behavior will elucidate trends in bypass rates and factors that may predict higher or lower rates. Main research question: What are the factors that have been proposed to affect hospital choice among rural residents seeking surgery? Objective: Using results from a scoping review of the literature, we will build a conceptual model of hospital choice for rural residents seeking surgery.
title: Can breast cancer biopsy influence sentinel lymph node status?
Creators: name: Rella, Rossella
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Ultrasound
subject: Biopsy
subject: Cancer
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Spreading neoplastically altered cells from a tumour during biopsy or simple procedure like needle aspiration is a possibility because they lack cohesiveness, and they attain the capacity to migrate and colonize [1, 2]. Considering the fact that...
Identity threat in response to gender differences in academic achievement
Creators: name: Sicard, Alyson
name: Martinot, Delphine
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This registration comprises the study material for the two studies in this project, prior to the publication of the results in a peer review article.
DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase
Creators: name: Köseoğlu, M. Murat
name: Djakbarova, Umidahan
name: Marzluff, William F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In eukaryotes, bulk histone expression occurs in the S phase of the cell cycle. This highly conserved system is crucial for genomic stability and proper gene expression. In metazoans, Stem-loop binding protein (SLBP), which binds to 3′ ends of canonical histone mRNAs, is a key factor in histone biosynthesis. SLBP is mainly expressed in S phase and this is a major mechanism to limit bulk histone production to the S phase. At the end of S phase, SLBP is rapidly degraded by proteasome, depending on two phosphorylations on Thr 60 and Thr 61. Previously, we showed that SLBP fragment (aa 51–108) fused to GST, is sufficient to mimic the late S phase (S/G2) degradation of SLBP. Here, using this fusion protein as bait, we performed pull-down experiments and found that DCAF11, which is a substrate receptor of CRL4 complexes, binds to the phosphorylated SLBP fragment. We further confirmed the interaction of full-length SLBP with DCAF11 and Cul4A by co-immunoprecipitation experiments. We also showed that DCAF11 cannot bind to the Thr61/Ala mutant SLBP, which is not degraded at the end of S phase. Using ectopic expression and siRNA experiments, we demonstrated that SLBP expression is inversely correlated with DCAF11 levels, consistent with the model that DCAF11 mediates SLBP degradation. Finally, we found that ectopic expression of the S/G2 stable mutant SLBP (Thr61/Ala) is significantly more toxic to the cells, in comparison to wild type SLBP. Overall, we concluded that CRL4-DCAF11 mediates the degradation of SLBP at the end of S phase and this degradation is essential for the viability of cells.
Educational content for patients with acute non-specific low back pain – A systematic analysis of the literature.
Creators: name: Zerritsch, Isabella
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Physiotherapy
subject: Medicine and Health Sciences
subject: Education
subject: Rehabilitation and Therapy

description: The aim of the study is to provide a comprehensive overview of all potential patient education contents for acute non-specific low back pain using a systematic analysis of the literature to provide a starting point for specifying structured education contents. To identify appropriate publications, a systematic literature search will be performed in the databases Medline (via Pubmed), CINAHL, Cochrane, and Pedro. In addition, secondary and gray literature is searched via publisher databases (Springer, Thieme) and dissertations via Dissonline. Hand-searching will include the reference lists of previously identified publications. Every content which can be identified as potential part of education for patients with acute low back pain will be extracted from the publications meeting the inclusion criteria. The main outcome of the review will be a comprehensive and evidence-based collection of educational content for patients with acute non-specific low back pain.
Probe of new light Higgs bosons from bottomonium chi_{b0} decay
Creators: name: Godfrey, Stephen
name: Logan, Heather E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We calculate the branching ratios of chi_{b0} --> tau+ tau- via an s-channel Higgs boson and estimate the sensitivity to this process from Upsilon --> gamma chi_{b0} --> gamma tau+ tau-. We show that future running at the Upsilon(3S) at a very high luminosity super B factory can put significant constraints on the Type-II two-Higgs-doublet model when the discovered 125 GeV Higgs boson is the heavier of the two CP-even scalars.
description: 7 pages, 2 figures. v2: minor improvements to text. v3: several refs added, discussion expanded, competing processes considered, conclusions unchanged
Key Success Factors for the CompetitiveAdvantagesof Human ResourcesManagement onGolf Tourism in ChiangMa
Creators: name: ChanikaChatsungnern
Publisher: name: Mae Jo University, Thailand.
Year: 2018
Subjects: Internal Organizational Environment, External Organizational, Environment,Human Resources Management, Challenge, & Key Success, Factors for the Competitive Advantages of Golf Tourism-Based Human Resources Management

description: ASEAN Journal of Management & Innovation, 5, 2, p 1-15
Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway
Creators: name: Maddox, Paul S.
name: Voisin, Laure
name: Meloche, Sylvain
name: Tanguay, Pierre-Luc
name: Duhamel, Stéphanie
name: Girondel, Charlotte
name: Dorn, Jonas F.
name: Smits, Ron
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Aneuploidy is a common feature of human solid tumors and is often associated with poor prognosis. There is growing evidence that oncogenic signaling pathways, which are universally dysregulated in cancer, contribute to the promotion of aneuploidy. However, the mechanisms connecting signaling pathways to the execution of mitosis and cytokinesis are not well understood. Here, we show that hyperactivation of the ERK1/2 MAP kinase pathway in epithelial cells impairs cytokinesis, leading to polyploidization and aneuploidy. Mechanistically, deregulated ERK1/2 signaling specifically downregulates expression of the F-box protein Fbxw7β, a substrate-binding subunit of the SCFFbxw7 ubiquitin ligase, resulting in the accumulation of the mitotic kinase Aurora A. Reduction of Aurora A levels by RNA interference or pharmacological inhibition of MEK1/2 reverts the defect in cytokinesis and decreases the frequency of abnormal cell divisions induced by oncogenic H-RasV12. Reciprocally, overexpression of Aurora A or silencing of Fbxw7β phenocopies the effect of H-RasV12 on cell division. In vivo, conditional activation of MEK2 in the mouse intestine lowers Fbxw7β expression, resulting in the accumulation of cells with enlarged nuclei. We propose that the ERK1/2/ Fbxw7β/Aurora A axis identified in this study contributes to genomic instability and tumor progression.
Clinical practice guidelines for recurrent miscarriage in high-income countries: A systematic review
Creators: name: Hennessy, Marita
name: Dennehy, Rebecca
name: Meaney, Sarah
name: Linehan, Laura
name: Devane, Declan
name: O'Donoghue, Keelin
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: This is a registration of data underlying the manuscript accepted for publication in Reproductive BioMedicine Online: (i) original data extraction file, and (ii) AGREEII evaluations.
Treatment of MOG-IgG associated disease in paediatric patients: a systematic review
Creators: name: da Costa, Bruna
name: Sato, Douglas
name: Banwell, Brenda
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: MOGAD
subject: MOG-IgG associated disease
subject: paediatric CNS inflammatory demyelinating diseases

description: Systematic review of the literature on treatment of paediatric patients with MOG-IgG associated disease (MOGAD).
title: Prognostic importance of SWE on breast cancer: lysyl oxidase gene study
Creators: name: Kayadibi, Yasemin
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Elastography
subject: Biopsy
subject: Laboratory tests
subject: Neoplasia
subject: Image verification

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Shear wave elastography (SWE) is a new developed technique, which can provide quantitative elasticity values by calculating the velocity of transverse shear waves through the tissue [1]. By this property, SWE improves the sensitivity and specifity...
Heme oxygenase-1 in the forefront of a multi-molecular network that governs cell–cell contacts and filopodia-induced zippering in prostate cancer
Creators: name: Bruno, Luciana
name: Salierno, Marcelo
name: Cotignola, Javier H.
name: Labanca, Estefania
name: Giudice, Jimena
name: Valacco, Maria Pia
name: Vazquez, Elba S.
name: Martí, Marcelo A.
name: Anselmino, Nicolás
name: Binaghi, Maria
name: Gueron, Geraldine
name: Levi, Valeria
name: Navone, Nora
name: Ortiz, Emiliano G.
name: Paez, Alejandra V.
name: Pallavicini, Carla
name: Woloszynska-Read, Anna
name: Schuster, Federico
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Prostate cancer (PCa) cells display abnormal expression of cytoskeletal proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown that heme oxygenase 1 (HO-1) is implicated in cell morphology regulation in PCa. Here, through a multi 'omics' approach we define the HO-1 interactome in PCa, identifying HO-1 molecular partners associated with the integrity of the cellular cytoskeleton. The bioinformatics screening for these cytoskeletal-related partners reveal that they are highly misregulated in prostate adenocarcinoma compared with normal prostate tissue. Under HO-1 induction, PCa cells present reduced frequency in migration events, trajectory and cell velocity and, a significant higher proportion of filopodia-like protrusions favoring zippering among neighboring cells. Moreover forced expression of HO-1 was also capable of altering cell protrusions in transwell co-culture systems of PCa cells with MC3T3 cells (pre-osteoblastic cell line). Accordingly, these effects were reversed under siHO. Transcriptomics profiling evidenced significant modulation of key markers related to cell adhesion and cell–cell communication under HO-1 induction. The integration from our omics-based research provides a four molecular pathway foundation (ANXA2/HMGA1/POU3F1; NFRSF13/GSN; TMOD3/RAI14/VWF; and PLAT/PLAU) behind HO-1 regulation of tumor cytoskeletal cell compartments. The complementary proteomics and transcriptomics approaches presented here promise to move us closer to unravel the molecular framework underpinning HO-1 involvement in the modulation of cytoskeleton pathways, pushing toward a less aggressive phenotype in PCa.
title: Role of STIR and T2-weighted TSE MR sequences for recognizing occult inflammatory breast cancer
Creators: name: Moschetta, Marco
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: MR
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Occultinflammatorybreastcancer is defined as an invasive cancer without any clinical inflammatory signs but with pathologically proven dermal lymphovascular invasion. Some studies reported thatMRI can predict occult IBC on the basis of thepresence...
Ubaldino Peruzzi a Luigi Calamai (24 febbraio 1848)
Creators: name: Peruzzi, Ubaldino
name: Calamai, Luigi
Publisher: name: Zenodo
Year: 2023
Subjects: Peruzzi, Ubaldino
Accademia dei Georgofili
Calamai, Luigi
Lettera
Carteggio
Correspondence
Letter
1848

description: Lettera di Ubaldino Peruzzi a Luigi Calamai del 24 febbraio 1848. Segnatura dell'unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio, Busta 29, 2181. Natura del documento: manoscritto. Consistenza: cc. 2.
description: Digitalizzato come parte della Mostra virtuale: Ubaldino Peruzzi : un percorso in rete : in occasione del bicentenario della nascita. https://www.georgofili.it/contenuti/ubaldino-peruzzi-un-percorso-in-rete/17485
Factors Affecting the Willingness to Pay for Solar Home Systems: An Empirical Study in Bangkok, Nonthaburi, Pathum Thani, and Samut Prakan Provinces, Thailand
Creators: name: Suthathip Suanmali
Publisher: name: Thammasat University
Year: 2018
Subjects: Contingent valuation method, Solar home system, Willingness to pay, Bidding game question, Adoption process, Binary logistic regression, Environmental awareness, Green product

description: ASEAN Journal of Management & Innovation, 5, 2, p 63-76
Robustness to outliers in location-scale parameter model using log-regularly varying distributions
Creators: name: Desgagné, Alain
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Estimating the location and scale parameters is common in statistics, using, for instance, the well-known sample mean and standard deviation. However, inference can be contaminated by the presence of outliers if modeling is done with light-tailed distributions such as the normal distribution. In this paper, we study robustness to outliers in location-scale parameter models using both the Bayesian and frequentist approaches. We find sufficient conditions (e.g., on tail behavior of the model) to obtain whole robustness to outliers, in the sense that the impact of the outliers gradually decreases to nothing as the conflict grows infinitely. To this end, we introduce the family of log-Pareto-tailed symmetric distributions that belongs to the larger family of log-regularly varying distributions.
description: Published at http://dx.doi.org/10.1214/15-AOS1316 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Navigating the Research Software Engineering Community Landscape in Asia
Creators: name: Bhogal, Saranjeet Kaur
Publisher: name: Zenodo
Year: 2023
Subjects: Research Software Engineering
Community Engagement
Community Management
Open Science

description: Talk presented at the 56th meeting of the Asia Pacific Advanced Network (APAN56) during 21-25 August 2023 at Colombo, Sri Lanka.
Proprioceptive neuromuscular facilitation-based physical therapy on improvement of balance and gait in patients with chronic stroke: A systematic review and meta-analysis
Creators: name: Nguyen, Phan The
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: Proprioceptive neuromuscular facilitation (PNF) has been used for early rehabilitation for improving motor functions of stroke patients. However, evaluation of its merit on balance and gait in chronic stroke patients is limited. This study determines the potential benefits of PNF on balance and gait function in patients with chronic stroke. A systematic database search was conducted for randomized control trials (RCTs) that investigated the effects of PNF intervention in patients with chronic stroke using balance and gait parameters as outcome measures. The primary outcomes of interest were Berg Balance Scale (BBS), Functional Reach Test (FRT), Timed Up and Go Test (TUG) and 10-Meter Walking Test (10MWT).
Non-communicable diseases: mapping research funding organisations, funding mechanisms and research practices in Italy and Germany
Creators: name: Stephani, Victor
name: Sommariva, Silvia
name: Spranger, Anne
name: Ciani, Oriana
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 610 Medizin und Gesundheit
subject: non-communicable diseases
subject: biomedical research
subject: Germany
subject: Italy
subject: cross-country comparison
subject: funding

description: Background Evidence shows that territorial borders continue to have an impact on research collaboration in Europe. Knowledge of national research structural contexts is therefore crucial to the promotion of Europe-wide policies for research funding. Nevertheless, studies assessing and comparing research systems remain scarce. This paper aims to further the knowledge on national research landscapes in Europe, focusing on non-communicable disease (NCD) research in Italy and Germany. Methods To capture the architecture of country-specific research funding systems, a three-fold strategy was adopted. First, a literature review was conducted to determine a list of key public, voluntary/private non-profit and commercial research funding organisations (RFOs). Second, an electronic survey was administered qualifying RFOs. Finally, survey results were integrated with semi-structured interviews with key opinion leaders in NCD research. Three major dimensions of interest were investigated – funding mechanisms, funding patterns and expectations regarding outputs. Results The number of RFOs in Italy is four times larger than that in Germany and the Italian research system has more project funding instruments than the German system. Regarding the funding patterns towards NCD areas, in both countries, respiratory disease research resulted as the lowest funded, whereas cancer research was the target of most funding streams. The most reported expected outputs of funded research activity were scholarly publication of articles and reports.