The European Reference Network for Rare Neurological Diseases
Creators: name: Reinhard, Carola
name: Bachoud-Lévi, Anne-Catherine
name: Bäumer, Tobias
name: Bertini, Enrico
name: Brunelle, Alicia
name: Buizer, Annemieke I.
name: Federico, Antonio
name: Gasser, Thomas
name: Groeschel, Samuel
name: Hermanns, Sanja
name: Klockgether, Thomas
name: Krägeloh-Mann, Ingeborg
name: Landwehrmeyer, G. Bernhard
name: Leber, Isabelle
name: Macaya, Alfons
name: Mariotti, Caterina
name: Meissner, Wassilios G.
name: Molnar, Maria Judit
name: Nonnekes, Jorik
name: Ortigoza Escobar, Juan Dario
name: Pérez Dueñas, Belen
name: Renna Linton, Lori
name: Schöls, Ludger
name: Schuele, Rebecca
name: Tijssen, Marina A. J.
name: Vandenberghe, Rik
name: Volkmer, Anna
name: Wolf, Nicole I.
name: Graessner, Holm
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: rare neurological diseases
subject: standards of care
subject: training and education
subject: virtual healthcare
subject: European reference network
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine &amp; health
subject: Nervous system diseases
subject: Rare diseases
subject: Delivery of health care
subject: Nervenkrankheit
subject: Seltene Krankheit
subject: Medizinische Versorgung

description: While rare diseases (RDs) are by definition of low prevalence, the total number of patients suffering from an RD is high, and the majority of them have neurologic manifestations, involving central, peripheral nerve, and muscle. In 2017, 24 European Reference Networks (ERNs), each focusing on a specific group of rare or low-prevalence complex diseases, were formed to improve the care for patients with an RD. One major aim is to have “the knowledge travel instead of the patient,” which has been put into practice by the implementation of the Clinical Patient Management System (CPMS) that enables clinicians to perform pan-European virtual consultations. The European Reference Network for Rare Neurological Diseases (ERN-RND) provides an infrastructure for knowledge sharing and care coordination for patients affected by a rare neurological disease (RND) involving the most common central nervous system pathological conditions. It covers the following disease groups: (i) Cerebellar Ataxias and Hereditary Spastic Paraplegias; (ii) Huntington's disease and Other Choreas; (iii) Frontotemporal dementia; (iv) Dystonia, (non-epileptic) paroxysmal disorders, and Neurodegeneration with Brain Iron Accumulation; (v) Leukoencephalopathies; and (vi) Atypical Parkinsonian Syndromes. At the moment, it unites 32 expert centers and 10 affiliated partners in 21 European countries, as well as patient representatives, but will soon cover nearly all countries of the European Union as a result of the ongoing expansion process. Disease expert groups developed and consented on diagnostic flowcharts and disease scales to assess the different aspects of RNDs. ERN-RND has started to discuss diagnostically unclear patients in the CPMS, is one of four ERNs that serve as foundation of Solve-RD, and has established an RND training and education program. The network will facilitate trial readiness through the establishment of an ERN-RND registry with a minimal data of all patients seen at the ERN-RND centers, thus providing a unique overview of existing genotype-based cohorts. The overall aim of the ERNs is to improve access for patients with RDs to quality diagnosis, care, and treatment. Based on this objective, ERNs are monitored by the European Commission on a regular basis to provide transparency and reassurance to the RD community and the general public.