cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Heterogeneous validity of daily data on symptoms of seasonal allergic rhinitis recorded by patients using the e‐diary AllergyMonitor®
Creators: name: Dramburg, Stephanie
name: Perna, Serena
name: Di Fraia, Marco
name: Tripodi, Salvatore
name: Arasi, Stefania
name: Castelli, Sveva
name: Villalta, Danilo
name: Buzzulini, Francesca
name: Sfika, Ifigenia
name: Villella, Valeria
name: Potapova, Ekaterina
name: Brighetti, Maria Antonia
name: Travaglini, Alessandro
name: Verardo, Pier Luigi
name: Pelosi, Simone
name: Matricardi, Paolo Maria
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: allergic rhinitis
subject: mHealth
subject: patient-generated data
subject: patient-reported outcomes
subject: symptom scores
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Patient-generated symptom and medication scores are essential for diagnostic and therapeutic decisions in seasonal allergic rhinitis (SAR). Previous studies have shown solid consistencies between different scores at population level in real-life data and trials. For clinicians, the evaluation of individual data quality over time is essential to decide whether to rely on these data in clinical decision-making. Objective: To analyze the consistency of different symptom (SS) and symptom medication scores (SMSs) at individual level in two study cohorts with different characteristics and explore individual patient trajectories over time. Methods: Within the pilot phase of the @IT.2020 project on diagnostic synergy of mobile health and molecular IgE assessment in patients with SAR, we analyzed data of 101 children and 93 adults with SAR and instructed them to record their symptoms and medication intake daily via the mobile app AllergyMonitor®. We then assessed the correlation between different SMS and a visual analogue scale (VAS) on the impact of allergy symptoms on daily life at population and individual level. Results: At population level, the Rhinoconjunctivitis total symptom score (RTSS) correlated better with VAS than the combined symptom and medication score (CSMS). At individual level, consistency among RTSS and VAS was highly heterogeneous and unrelated to disease severity or adherence to recording. Similar heterogeneity was observed for CSMS and VAS. Conclusions: The correlation of clinical information provided by different disease severity scores based on data collected via electronic diaries (e-diaries), is sufficient at population level, but broadly heterogeneous for individual patients. Consistency of the recorded data must be examined for each patient before remotely collected information is used for clinical decision making.
Dynamical modelling of spontaneous oscillation during nanostructuring burnishing
Creators: name: Lyashenko I., A.
name: Kuznetsov V., P.
name: Popov M.
name: Popov V., L.
name: Gorgots V., G.
Publisher: name: Физическая мезомеханика
Year: 2015
Subjects: ВЫГЛАЖИВАНИЕ
НЕЛИНЕЙНАЯ ДИНАМИКА
ПРОФИЛЬ ПОВЕРХНОСТИ
ПОДАВЛЕНИЕ КОЛЕБАНИЙ
BURNISHING
NONLINEAR DYNAMICS
SURFACE PATTERNS
SUPPRESSION OF INSTABILITIES

description: We study experimentally and theoretically the process of nanostructuring burnishing by a spherical indenter and show that if the smoothing surfaces contain a localized unevenness (a drilled hole), a stable limiting cycle of self-excited oscillations may occur, which results in wavy permanent deformation of the surface. We propose a numerical model for computing the topography of a surface that has been subjected to nanostructuring burnishing and show that it is in a good qualitative agreement with the experimental observations. Based on the model, the critical value of the damping is determined suppressing the oscillating mode.
Generalized multi-plane gravitational lensing: time delays, recursive lens equation, and the mass-sheet transformation
Creators: name: Schneider, Peter
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We consider several aspects of the generalized multi-plane gravitational lens theory, in which light rays from a distant source are affected by several main deflectors, and in addition by the tidal gravitational field of the large-scale matter distribution in the Universe when propagating between the main deflectors. Specifically, we derive a simple expression for the time-delay function in this case, making use of the general formalism for treating light propagation in inhomogeneous spacetimes which leads to the characterization of distance matrices between main lens planes. Applying Fermat's principle, an alternative form of the corresponding lens equation is derived, which connects the impact vectors in three consecutive main lens planes, and we show that this form of the lens equation is equivalent to the more standard one. For this, some general relations for cosmological distance matrices are derived. The generalized multi-plane lens situation admits a generalized mass-sheet transformation, which corresponds to uniform isotropic scaling in each lens plane, a corresponding scaling of the deflection angle, and the addition of a tidal matrix (mass sheet plus external shear) to each main lens. We show that the time delay for sources in all lens planes scale with the same factor under this generalized mass-sheet transformation, thus precluding the use of time-delay ratios to break the mass-sheet transformation.
description: 10 pages, 2 embedded figures. Submitted to A&A
Parking Spot Classification based on surround view camera system
Creators: name: Xiao, Andy
name: Doshi, Deep
name: Wang, Lihao
name: Gorantla, Harsha
name: Heitzmann, Thomas
name: Groth, Peter
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Surround-view fisheye cameras are commonly used for near-field sensing in automated driving scenarios, including urban driving and auto valet parking. Four fisheye cameras, one on each side, are sufficient to cover 360° around the vehicle capturing the entire near-field region. Based on surround view cameras, there has been much research on parking slot detection with main focus on the occupancy status in recent years, but little work on whether the free slot is compatible with the mission of the ego vehicle or not. For instance, some spots are handicap or electric vehicles accessible only. In this paper, we tackle parking spot classification based on the surround view camera system. We adapt the object detection neural network YOLOv4 with a novel polygon bounding box model that is well-suited for various shaped parking spaces, such as slanted parking slots. To the best of our knowledge, we present the first detailed study on parking spot detection and classification on fisheye cameras for auto valet parking scenarios. The results prove that our proposed classification approach is effective to distinguish between regular, electric vehicle, and handicap parking spots.
description: SPIE Optical Engineering + Applications, 2023, San Diego, California, United States. Proc. SPIE 12675, Applications of Machine Learning 2023
Myoglobin for Detection of High-Risk Patients with Acute Myocarditis
Creators: name: Kottwitz, Jan
name: Bruno, Katelyn A.
name: Berg, Jan
name: Salomon, Gary R.
name: Fairweather, DeLisa
name: Elhassan, Mawahib
name: Baltensperger, Nora
name: Kissel, Christine K.
name: Lovrinovic, Marina
name: Baltensweiler, Andrea
name: Schmied, Christian
name: Templin, Christian
name: Lima, Joao A.C.
name: Landmesser, Ulf
name: Lüscher, Thomas F.
name: Manka, Robert
name: Heidecker, Bettina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Biomarker
subject: Cardiac enzymes
subject: Late gadolinium enhancement
subject: Magnetic resonance imaging
subject: Myocardial inflammation
subject: Myocarditis
subject: Myoglobin
subject: Troponin
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (rs = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (rs = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. Graphical Abstract Receiver operating curve analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis and these data were reproduced in an established model of coxsackievirus B3 myocarditis in mice: CMRI, cardiac magnetic resonance imaging; Mb, myoglobin; LGE, late gadolinium enhancement; ROC, receiver operating curve analysis.
title: Unequal access to the global financial safety net
title: an index for the quality of crisis finance
titleType: Subtitle
Creators: name: Zucker Marques, Marina
name: Mühlich, Laurissa
name: Fritz, Barbara
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Global financial safety net
subject: financial crisis
subject: short-term crisis finance
subject: IMF
subject: central bank policies
subject: regional financial arrangements
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft
subject: 300 Sozialwissenschaften::330 Wirtschaft::332 Finanzwirtschaft

description: The Global Financial Safety Net (GFSN) – the institutions and arrangements that provide short-term crisis finance – has turned into a highly complex, uncoordinated system of global, multilateral, and bilateral instruments. The present paper elaborates on a composite index of the GFSN to analyse its preparedness for shielding countries from financial crises. This first-of-its-kind index comprises six components that measure the vulnerability and resilience of individual countries to financial crises derived from economic and political economy financial crisis literature. We apply this index to data from 192 UN member countries we collected in the GFSN tracker for the period of the COVID-19 pandemic in terms of their asses to and use of the GFSN. This index, and the use of novel forms of graphical displaying, allow us to identify a hierarchy in the access to short-term liquidity by the GFSN. At the bottom, we find low-income countries with sole access to IMF standard conditional crisis finance, while we find at the top countries with access to bilateral currency swaps, especially those provided by the US Federal Reserve. Our analysis also reveals that first, the temporary reformed unconditional access of IMF crisis finance during the pandemic has temporarily improved those countries’ position in the GFSN hierarchy; second, bilateral swaps as crisis finance instruments reinforce the GFSN hierarchy. Since access to adequate emergency liquidity is decisive for a country’s financial crisis prevention capacity and the ability to engage in social cohesion and climate policy, we suggest to flatten the hierarchy by keeping access to IMF unconditional finance open beyond the COVID-19 crisis, expanding regional financial arrangements, and by coordinating GFSN elements, including currency swap providing central banks.
An analysis of Ermakov-Zolotukhin quadrature using kernels
Creators: name: Belhadji, Ayoub
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: Computation (stat.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We study a quadrature, proposed by Ermakov and Zolotukhin in the sixties, through the lens of kernel methods. The nodes of this quadrature rule follow the distribution of a determinantal point process, while the weights are defined through a linear system, similarly to the optimal kernel quadrature. In this work, we show how these two classes of quadrature are related, and we prove a tractable formula of the expected value of the squared worst-case integration error on the unit ball of an RKHS of the former quadrature. In particular, this formula involves the eigenvalues of the corresponding kernel and leads to improving on the existing theoretical guarantees of the optimal kernel quadrature with determinantal point processes.
Combined Experimental and Theoretical Studies on Iodine Capture of Zr-based Metal-Organic Frameworks: Effect of N-functionalization and Adsorption Mechanism
Creators: name: Liang, Jie
name: Tan, Haoyi
name: Liu, Jiaomei
name: Qi, Huizhao
name: Li, Xin
name: Wu, Liu
name: Xue, Xiangfei
name: Shan, Guangcun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The potential leakage of nuclear waste, especially radioiodine, is a major safety concerning issue around the world. To remove radioiodine from nuclear waste efficiently, there is an urgent demand for adsorbents that possess both high stability and strong adsorption affinity for environmental remediation. Herein, two Zr-based metal-organic frameworks (Zr-MOFs) and their N-functionalized analogues have been synthesized and researched for iodine adsorption in both vapours and solutions. It was found that Zr-MOFs with N-enriched ligands (e.g., pyridine and amino) exhibited the faster iodine adsorption rate and the higher iodine uptake amount (e.g., reaching adsorption equilibrium within 4 hours with the removal rate of above 85% for iodine solution adsorption) than their unfunctionalized counterparts (UiO-66 and UiO-67). The critical role played by N-enriched groups in enhancing iodine adsorption has been revealed through versatile model fittings, X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy characterizations, as well as density functional theory (DFT) calculations. Compared to those in amino-group, the N-atoms in pyridine-groups showed a deeper affinity towards iodine molecules. Remarkably, the N-enriched UiOs adsorbents also exhibited good recyclability, especially UiO-66-PYDC and UiO-67-NH2 could maintain the removal efficiency of 89.05% and 85.49% after four adsorption-desorption recycling tests. With the strong iodine uptake affinity and outstanding regeneration performance, this work has systematically investigated the impact of N-functionalization on the enhanced performance for iodine capture by using the N-enriched UiO MOFs as promising adsorbents, providing an insightful guideline into the physical chemistry of adsorption mechanism behind the radioiodine capture.
description: 28 pages, in press, Materials Today Sustainability Available online 4 October 2023, 100574
A quiescent galaxy at the position of the long GRB 050219A
Creators: name: Rossi, A.
name: Piranomonte, S.
name: Savaglio, S.
name: Palazzi, E.
name: Michałowski, M. J.
name: Klose, S.
name: Hunt, L. K.
name: Amati, L.
name: Elliott, J.
name: Greiner, J.
name: Guidorzi, C.
name: Japelj, J.
name: Kann, D. A.
name: Faro, B. Lo
name: Guelbenzu, A. Nicuesa
name: Schulze, S.
name: Vergani, S. D.
name: Arnold, L. A.
name: Covino, S.
name: D'Elia, V.
name: Ferrero, P.
name: Filgas, R.
name: Goldoni, P.
name: Yoldaş, A. Küpcü
name: Borgne, D. Le
name: Pian, E.
name: Schady, P.
name: Stratta, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Long-duration gamma-ray bursts (LGRBs) are produced by the collapse of very massive stars. Due to the short lifetime of their progenitors, LGRBs pinpoint star-forming galaxies. We present here a multi-band search for the host galaxy of the long dark GRB 050219A within the enhanced Swift/XRT error circle. We used spectroscopic observations acquired with VLT/X-shooter to determine the redshift and star-formation rate of the putative host galaxy. We compared the results with the optical/IR spectral energy distribution obtained with different facilities. Surprisingly, the host galaxy is a old and quiescent early-type galaxy at z = 0.211 characterised by an unprecedentedly low specific star-formation rate. It is the first LGRB host to be also an early-type post-starburst galaxy. This is further evidence that GRBs can explode in all kind of galaxies, with the only requirement being an episode of star-formation.
description: 11 pages, 10 figures, 3 tables; accepted for publication in Astronomy & Astrophysics
A Prospective Pilot Study to Identify a Myocarditis Cohort who may Safely Resume Sports Activities 3 Months after Diagnosis
Creators: name: Patriki, D.
name: Baltensperger, N.
name: Berg, J.
name: Cooper, L. T.
name: Kissel, C. K.
name: Kottwitz, J.
name: Lovrinovic, M.
name: Manka, R.
name: Scherff, F.
name: Schmied, C.
name: Tanner, F. C.
name: Luescher, T. F.
name: Heidecker, Bettina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Myocarditis
subject: Sudden cardiac death
subject: Magnetic resonance imaging
subject: Exercise
subject: Arrhythmia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: International cardiovascular society recommendations to return to sports activities following acute myocarditis are based on expert consensus in the absence of prospective studies. We prospectively enrolled 30 patients with newly diagnosed myocarditis based on clinical parameters, laboratory measurements and cardiac magnetic resonance imaging with mildly reduced or pre served left ventricular ejection fraction (LVEF) with a follow-up of 12 months. Cessation of physical activity was recommended for 3 months. The average age was 35 (19–80) years with 73% male patients. One case of non-sustained ventricular tachycardia was recorded during 48-h-Holter electrocardiogram. Except for this case, all patients were allowed to resume physical exercise after 3 months. At 6- (n = 26) and 12-month (n = 19) follow-up neither cardiac events nor worsening LVEF were recorded. The risk of cardiac events at 1 year after diagnosis of myocarditis appears to be low after resumption of exercise after 3 months among patients who recover from acute myocarditis.
Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells
Creators: name: Xu, Xun
name: Nie, Yan
name: Wang, Weiwei
name: Ma, Nan
name: Lendlein, Andreas
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Actuation
subject: Antiviral
subject: Biomaterial
subject: COVID-19
subject: Shape memory
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.
A Toolbox of Potential Immune-Related Therapies for Inflammatory Cardiomyopathy
Creators: name: Elsanhoury, Ahmed
name: Tschöpe, Carsten
name: Van Linthout, Sophie
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Immunomodulation
subject: Immunosuppression
subject: Inflammatory cardiomyopathy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Myocarditis is a multifactorial disorder, characterized by an inflammatory reaction in the myocardium, predominantly triggered by infectious agents, but also by antigen mimicry or autoimmunity in susceptible individuals. Unless spontaneously resolved, a chronic inflammatory course concludes with cardiac muscle dysfunction portrayed by ventricular dilatation, clinically termed inflammatory cardiomyopathy (Infl-CM). Treatment strategies aim to resolve chronic inflammation and preserve cardiac function. Beside standard heart failure treatments, which only play a supportive role in this condition, systemic immunosuppressants are used to diminish inflammatory cell function at the cost of noxious side effects. To date, the treatment protocols are expert-based without large clinical evidence. This review describes concept and contemporary strategies to alleviate myocardial inflammation and sheds light on potential inflammatory targets in an evidence-based order.
Evolution of turbulence in the expanding solar wind, a numerical study
Creators: name: Dong, Yue
name: Verdini, Andrea
name: Grappin, Roland
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We study the evolution of turbulence in the solar wind by solving numerically the full 3D magneto-hydrodynamic (MHD) equations embedded in a radial mean wind. The corresponding equations (expanding box model or EBM) have been considered earlier but never integrated in 3D simulations. Here, we follow the development of turbulence from 0.2 AU up to about 1.5 AU. Starting with isotropic spectra scaling as $k^{-1}$, we observe a steepening toward a $k^{-5/3}$ scaling in the middle of the wavenumber range and formation of spectral anisotropies. The advection of a plasma volume by the expanding solar wind causes a non-trivial stretching of the volume in directions transverse to radial and the selective decay of the components of velocity and magnetic fluctuations. These two effects combine to yield the following results. (i) Spectral anisotropy: gyrotropy is broken, and the radial wavevectors have most of the power. (ii) Coherent structures: radial streams emerge that resemble the observed microjets. (iii) Energy spectra per component: they show an ordering in good agreement with the one observed in the solar wind at 1 AU. The latter point includes a global dominance of the magnetic energy over kinetic energy in the inertial and $f^{-1}$ range and a dominance of the perpendicular-to-the-radial components over the radial components in the inertial range. We conclude that many of the above properties are the result of evolution during transport in the heliosphere, and not just the remnant of the initial turbulence close to the Sun.
description: 14 pages, 12 figures, accepted in ApJ
A clear age-velocity dispersion correlation in Andromeda's stellar disk
Creators: name: Dorman, Claire E.
name: Guhathakurta, Puragra
name: Seth, Anil C.
name: Weisz, Daniel R.
name: Bell, Eric F.
name: Dalcanton, Julianne J.
name: Gilbert, Karoline M.
name: Hamren, Katherine M.
name: Lewis, Alexia R.
name: Skillman, Evan D.
name: Toloba, Elisa
name: Williams, Benjamin F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The stellar kinematics of galactic disks are key to constraining disk formation and evolution processes. In this paper, for the first time, we measure the stellar age-velocity dispersion correlation in the inner 20 kpc (3.5 disk scale lengths) of M31 and show that it is dramatically different from that in the Milky Way. We use optical Hubble Space Telescope/Advanced Camera for Surveys photometry of 5800 individual stars from the Panchromatic Hubble Andromeda Treasury (PHAT) survey and Keck/DEIMOS radial velocity measurements of the same stars from the Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo (SPLASH) survey. We show that the average line-of-sight velocity dispersion is a steadily increasing function of stellar age exterior to R=10 kpc, increasing from 30 km/s for the young upper main sequence stars to 90 km/s for the old red giant branch stars. This monotonic increase implies that a continuous or recurring process contributed to the evolution of the disk. Both the slope and normalization of the dispersion vs. age relation are significantly larger than in the Milky Way, allowing for the possibility that the disk of M31 has had a more violent history than the disk of the Milky Way, more in line with cosmological predictions. We also find evidence for an inhomogeneous distribution of stars from a second kinematical component in addition to the dominant disk component. One of the largest and hottest high-dispersion patches is present in all age bins, and may be the signature of the end of the long bar.
description: Accepted for publication in ApJ. Figure 12 is the money plot
Polydopamine-based biofunctional substrate coating promotes mesenchymal stem cell migration
Creators: name: Deng, Zijun
name: Wang, Weiwei
name: Xu, Xun
name: Ma, Nan
name: Lendlein, Andreas
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Materials Science, general
subject: Materials Engineering
subject: FOS: Materials engineering
subject: Applied and Technical Physics
subject: Nanotechnology
subject: FOS: Nanotechnology
subject: Characterization and Evaluation of Materials
subject: Biomaterials
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Rapid migration of mesenchymal stem cells (MSCs) on device surfaces could support in vivo tissue integration and might facilitate in vitro organoid formation. Here, polydopamine (PDA) is explored as a biofunctional coating to effectively promote MSC motility. It is hypothesized that PDA stimulates fibronectin deposition and in this way enhances integrin-mediated migration capability. The random and directional cell migration was investigated by time-lapse microscopy and gap closure assay respectively, and analysed with softwares as computational tools. A higher amount of deposited fibronectin was observed on PDA substrate, compared to the non-coated substrate. The integrin β1 activation and focal adhesion kinase (FAK) phosphorylation at Y397 were enhanced on PDA substrate, but the F-actin cytoskeleton was not altered, suggesting MSC migration on PDA was regulated by integrin initiated FAK signalling. This study strengthens the biofunctionality of PDA coating for regulating stem cells and offering a way of facilitating tissue integration of devices.
Perioperative echocardiography-guided hemodynamic therapy in high-risk patients: a practical expert approach of hemodynamically focused echocardiography
Creators: name: Trauzeddel, Ralf Felix
name: Ertmer, Martin
name: Nordine, Michael
name: Groesdonk, Heinrich V.
name: Michels, Guido
name: Pfister, Roman
name: Reuter, Daniel
name: Scheeren, T. W. L.
name: Berger, Christian
name: Treskatsch, Sascha
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Echocardiography
subject: Hemodynamic optimization
subject: Monitoring
subject: Perioperative
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The number of high-risk patients undergoing surgery is growing. To maintain adequate hemodynamic functioning as well as oxygen delivery to the vital organs (DO2) amongst this patient population, a rapid assessment of cardiac functioning is essential for the anesthesiologist. Pinpointing any underlying cardiovascular pathophysiology can be decisive to guide inter ventions in the intraoperative setting. Various techniques are available to monitor the hemodynamic status of the patient, however due to intrinsic limitations, many of these methods may not be able to directly identify the underlying cause of cardiovascular impairment. Hemodynamic focused echocardiography, as a rapid diagnostic method, ofers an excellent opportunity to examine signs of flling impairment, cardiac preload, myocardial contractility and the function of the heart valves. We thus propose a 6-step-echocardiographic approach to assess high-risk patients in order to improve and maintain perioperative DO2. The summary of all echocardiographic based fndings allows a diferentiated assessment of the patient’s cardiovascular function and can thus help guide a (patho)physiological-orientated and individualized hemodynamic therapy.
Detecting Speech Abnormalities with a Perceiver-based Sequence Classifier that Leverages a Universal Speech Model
Creators: name: Soltau, Hagen
name: Shafran, Izhak
name: Ottenwess, Alex
name: Duffy, Joseph R. JR
name: Utianski, Rene L.
name: Barnard, Leland R.
name: Stricker, John L.
name: Wiepert, Daniela
name: Jones, David T.
name: Botha, Hugo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: We propose a Perceiver-based sequence classifier to detect abnormalities in speech reflective of several neurological disorders. We combine this classifier with a Universal Speech Model (USM) that is trained (unsupervised) on 12 million hours of diverse audio recordings. Our model compresses long sequences into a small set of class-specific latent representations and a factorized projection is used to predict different attributes of the disordered input speech. The benefit of our approach is that it allows us to model different regions of the input for different classes and is at the same time data efficient. We evaluated the proposed model extensively on a curated corpus from the Mayo Clinic. Our model outperforms standard transformer (80.9%) and perceiver (81.8%) models and achieves an average accuracy of 83.1%. With limited task-specific data, we find that pretraining is important and surprisingly pretraining with the unrelated automatic speech recognition (ASR) task is also beneficial. Encodings from the middle layers provide a mix of both acoustic and phonetic information and achieve best prediction results compared to just using the final layer encodings (83.1% vs. 79.6%). The results are promising and with further refinements may help clinicians detect speech abnormalities without needing access to highly specialized speech-language pathologists.
Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
Creators: name: Rubens, Muni
name: Saxena, Anshul
name: Ramamoorthy, Venkataraghavan
name: Ahmed, Md Ashfaq
name: Zhang, Zhenwei
name: McGranaghan, Peter
name: Veledar, Emir
name: McDermott, Michael
name: De Los Rios La Rosa, Felipe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: coronavirus
subject: death
subject: hospitalization
subject: ischemic stroke
subject: morbidity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective analysis of data from California State Inpatient Database (SID) during 2019 and 2020. COVID-19 hospitalizations with age >= 18 years during 2020 and a historical cohort without COVID-19 from 2019 were included in the analysis. The primary outcomes studied were in-hospital mortality and discharge to destinations other than home. There were 91,420 COVID-19 hospitalizations, of which, 1027 (1.1%) had AIS. The historical control cohort included 58,083 AIS hospitalizations without COVID-19. Conditional logistic regression analysis showed that the odds of in-hospital mortality, discharge to destinations other than home, DVT, pulmonary embolism, septic shock, and mechanical ventilation were significantly higher among COVID-19 hospitalizations with AIS, compared to those without AIS. The odds of in-hospital mortality, DVT, pulmonary embolism, septic shock, mechanical ventilation, and respiratory failure were significantly higher among COVID-19 hospitalizations with AIS, compared to AIS hospitalizations without COVID-19. Although the prevalence of AIS was low among COVID-19 hospitalizations, it was associated with higher mortality and greater rates of discharges to destinations other than home.
Are There Extended Cognitive Improvements from Different Kinds of Acute Bouts of Physical Activity?
Creators: name: Haeger, Mathias
name: Bury, Nils
name: Endres, Christian
name: Klatt, Stefanie
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Cognition
subject: Executive functions
subject: Older adults
subject: Physical activity
subject: Young adults
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Acute bouts of physical activity of at least moderate intensity have shown to enhance cognition in young as well as older adults. This effect has been observed for different kinds of activities such as aerobic or strength and coordination training. However, only few studies have directly compared these activities regarding their effectiveness. Further, most previous studies have mainly focused on inhibition and have not examined other important core executive functions (i.e., updating, switching) which are essential for our behavior in daily life (e.g., staying focused, resisting temptations, thinking before acting), as well. Therefore, this study aimed to directly compare two kinds of activities, aerobic and coordinative, and examine how they might affect executive functions (i.e., inhibition, updating, and switching) in a test-retest protocol. It is interesting for practical implications, as coordinative exercises, for example, require little space and would be preferable in settings such as an office or a classroom. Furthermore, we designed our experiment in such a way that learning effects were controlled. Then, we tested the influence of acute bouts of physical activity on the executive functioning in both young and older adults (young 16-22 years, old 65-80 years). Overall, we found no differences between aerobic and coordinative activities and, in fact, benefits from physical activities occurred only in the updating tasks in young adults. Additionally, we also showed some learning effects that might influence the results. Thus, it is important to control cognitive tests for learning effects in test-retest studies as well as to analyze effects from physical activity on a construct level of executive functions.
colon RNA sequencing of colitis mice
Creators: name: 余婧婷(Jingting Yu)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Raw sequence reads
Genome sequencing
Assembly
Monoisolate
Model organism

description: To deeply investigate the underlying mechanisms responsible for Lacidophilin on ulcerative colitis, the transcriptome was conducted.
Revealing cytotoxic substructures in molecules using deep learning
Creators: name: Webel, Henry E.
name: Kimber, Talia B.
name: Radetzki, Silke
name: Neuenschwander, Martin
name: Nazaré, Marc
name: Volkamer, Andrea
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Cytotoxic substructures
subject: Deep Neural Networks
subject: Deep Taylor Decomposition
subject: Toxicophores
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In drug development, late stage toxicity issues of a compound are the main cause of failure in clinical trials. In silico meth ods are therefore of high importance to guide the early design process to reduce time, costs and animal testing. Technical advances and the ever growing amount of available toxicity data enabled machine learning, especially neural networks, to impact the feld of predictive toxicology. In this study, cytotoxicity prediction, one of the earliest handles in drug discovery, is investigated using a deep learning approach trained on a highly consistent in-house data set of over 34,000 compounds with a share of less than 5% of cytotoxic molecules. The model reached a balanced accuracy of over 70%, similar to previ ously reported studies using Random Forest. Albeit yielding good results, neural networks are often described as a black box lacking deeper mechanistic understanding of the underlying model. To overcome this absence of interpretability, a Deep Taylor Decomposition method is investigated to identify substructures that may be responsible for the cytotoxic efects, the so-called toxicophores. Furthermore, this study introduces cytotoxicity maps which provide a visual structural interpretation of the relevance of these substructures. Using this approach could be helpful in drug development to predict the potential toxicity of a compound as well as to generate new insights into the toxic mechanism. Moreover, it could also help to de-risk and optimize compounds.
Kardinal Döpfners Friedensaufruf an das deutsche und polnische Volk
Creators: name: Döpfner, Julius
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 15 Nr. 3 (1960): Herder Korrespondenz, Band 15, Heft 3
CaRegiving frOm A Distance (ROAD): home care in the future—flexible and nearby – multimethod qualitative study protocol
Creators: name: Budnick, Andrea
name: Bünning, Farina
name: Kuhlmey, Adelheid
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: QUALITATIVE RESEARCH
subject: PUBLIC HEALTH
subject: Protocols & guidelines
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Demographic change in Germany is accompanied by a birth rate deficit and increasing life expectancy. One effect of the ageing population is an increase in people needing care, most of whom want to grow old in their homes and to be cared for there. At the same time, informal caregivers are a core resource in the German care system, but due to social changes, this resource is not endless. Processes of social change in German society will cause further erosion in the potential number of informal local caregivers. Therefore, it will be increasingly important to provide conditions so that individuals at a distance who support people needing care are actually able to do so. Distance caregiving is a broad field, posing questions of intergenerational and intragenerational solidarity and the balance between work, family and caring responsibilities. Systematic research is required into opportunities and limitations, including innovative technology, in the whole field of care arrangements over a distance. The demands of the different actors in the distance caregiving arrangement are not yet known and are the subject of our study. Methods and analysis: This study will develop a model for distance caregiving. A qualitative multimethod research design (non-interventional study) will be adopted. The study will take place between September 2021 and August 2024. Participants will be selected by a purposeful sampling process. Phenomenological analysis will guide our data analysis. Data collected in this study will allow for triangulation, thereby increasing the trustworthiness of findings. Ethics and dissemination: Ethical approval for this study has been granted by the ethics committee of the Faculty of Medicine of the Charite, Universitatsmedizin Berlin (ID: EA1/371/21). Dissemination of the results will take place among the scientific community. Results will also be disseminated among the public and actors involved in healthcare and nursing care.
Arthroscopic iliac crest bone grafting in recurrent anterior shoulder instability: minimum 5-year clinical and radiologic follow-up
Creators: name: Boehm, Elisabeth
name: Minkus, Marvin
name: Moroder, Philipp
name: Scheibel, Markus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Shoulder instability
subject: Glenoid defect
subject: Autograft
subject: Autologous iliac crest bone grafting
subject: Anatomic glenoid reconstruction
subject: Bone block procedure
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: To investigate the clinical and radiologic mid- to long-term results of arthroscopic iliac crest bone-grafting for anatomic glenoid reconstruction in patients with recurrent anterior shoulder instability. Methods: Seventeen patients were evaluated after a minimum follow-up of 5 years. Clinical [range of motion, subscapularis tests, apprehension sign, Subjective Shoulder Value (SSV), Constant Score (CS), Rowe Score (RS), Walch Duplay Score (WD), Western Ontario Shoulder Instability Index (WOSI)], and radiologic [X-ray (true a.p., Bernageau and axillary views) and computed tomography (CT)] outcome parameters were assessed. Results: Fourteen patients [mean age 31.1 (range 18–50) years] were available after a follow-up period of 78.7 (range 60–110) months. The SSV averaged 87 (range 65–100) %, CS 94 (range 83–100) points, RS 89 (range 30–100) points, WD 87 (range 25–100) points, and WOSI 70 (range 47–87) %. The apprehension sign was positive in two patients (14%). One patient required an arthroscopic capsular plication due to a persisting feeling of instability, while the second patient experienced recurrent dislocations after a trauma, but refused revision surgery. CT imaging showed a signifcant increase of the glenoid index from preoperative 0.8±0.04 (range 0.7–0.8) to 1.0±0.11 (range 0.8–1.2) at the fnal follow-up (p<0.01). Conclusion: Arthroscopic reconstruction of anteroinferior glenoid defects using an autologous iliac crest bone-grafting tech nique yields satisfying clinical and radiologic results after a mid- to long-term follow-up period. Postoperative re-dislocation was experienced in one (7.1%) of the patients due to a trauma and an anatomic reconstruction of the pear-shaped glenoid confguration was observed. Level of evidence IV.
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Management of Low-Grade Gliomas and Radiation Necrosis: A Single-Institution Case Series
Creators: name: Scherschinski, Lea
name: Jubran, Jubran H.
name: Shaftel, Kelly A.
name: Furey, Charuta G.
name: Farhadi, Dara S.
name: Benner, Dimitri
name: Hendricks, Benjamin K.
name: Smith, Kris A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: low-grade glioma
subject: oligodendroglioma
subject: astrocytoma
subject: laser interstitial thermal therapy
subject: LITT
subject: minimally invasive
subject: survival
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Laser interstitial thermal therapy (LITT) has emerged as a minimally invasive treatment modality for ablation of low-grade glioma (LGG) and radiation necrosis (RN). Objective: To evaluate the efficacy, safety, and survival outcomes of patients with radiographically presumed recurrent or newly diagnosed LGG and RN treated with LITT. Methods: The neuro-oncological database of a quaternary center was reviewed for all patients who underwent LITT for management of LGG between 1 January 2013 and 31 December 2020. Clinical data including demographics, lesion characteristics, and clinical and radiographic outcomes were collected. Kaplan-Meier analyses comprised overall survival (OS) and progression-free survival (PFS). Results: Nine patients (7 men, 2 women; mean [SD] age 50 [16] years) were included. Patients underwent LITT at a mean (SD) of 11.6 (8.5) years after diagnosis. Two (22%) patients had new lesions on radiographic imaging without prior treatment. In the other 7 patients, all (78%) had surgical resection, 6 (67%) had intensity-modulated radiation therapy and chemotherapy, respectively, and 4 (44%) had stereotactic radiosurgery. Two (22%) patients had lesions that were wild-type IDH1 status. Volumetric assessment of preoperative T1-weighted contrast-enhancing and T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences yielded mean (SD) lesion volumes of 4.1 (6.5) cm(3) and 26.7 (27.9) cm(3), respectively. Three (33%) patients had evidence of radiographic progression after LITT. The pooled median (IQR) PFS for the cohort was 52 (56) months, median (IQR) OS after diagnosis was 183 (72) months, and median (IQR) OS after LITT was 52 (60) months. At the time of the study, 2 (22%) patients were deceased. Conclusions: LITT is a safe and effective treatment option for management of LGG and RN, however, there may be increased risk of permanent complications with treatment of deep-seated subcortical lesions.
The herbal extract EPs® 7630 increases the antimicrobial airway defense through monocyte-dependent induction of IL-22 in T cells
Creators: name: Witte, Katrin
name: Koch, Egon
name: Volk, Hans-Dieter
name: Wolk, Kerstin
name: Sabat, Robert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Antimicrobial proteins
subject: IL-17
subject: IL-22
subject: Monocyte
subject: NKT cell
subject: Pelargonium sidoides
subject: T cell
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The phytotherapeutic compound EPs® 7630, an extract manufactured from Pelargonium sidoides roots, is frequently used for the treatment of airway infections. Nevertheless, the knowledge of the mode of action of EPs® 7630 is still sparse. Our study aimed at further elucidating the underlying pharmacological mechanisms by focusing on antimicrobial defense mechanisms of EPs® 7630. While investigating the influence of EPs® 7630 on lymphokine production by PBMCs, we found that EPs® 7630 is a novel inducer of IL-22 and IL-17. This cytokine-inducing effect was most pronounced for IL-22 and clearly dose-dependent starting from 1 μg/ml of the extract. Furthermore, EPs® 7630 pretreatment selectively enhanced the IL-22 and IL-17 production capacity of CD3/28-activated PBMCs while strongly limiting the IFN-γ production capacity of innate lymphoid cells. The relevance of EPs® 7630-induced IL-22 production was proven in vitro and in vivo, where IL-22 provoked a strong increase of the antimicrobial protein S100A9 in lung epithelial cells and pulmonary tissue, respectively. A detailed analysis of IL-22 induction modi revealed no direct influence of EPs® 7630 on the basal or anti-CD3/CD28 antibody-induced IL-22 production by CD4+ memory T cells. In fact, EPs® 7630-induced IL-22 production by CD4+ memory T cells was found to be essentially dependent on soluble mediators (IL-1/IL-23) as well as on direct cellular contact with monocytes. In summary, our study reveals a new immune-modulating function of EPs® 7630 that might confer IL-22 and IL-17-induced protection from bacterial airway infection. KEY MESSAGES: EPs® 7630 selectively strengthens IL-22 and IL-17 production of memory T cells. EPs® 7630 limits the IFN-y production capacity of innate lymphoid cells. EPs® 7630-caused IL-22 production by T cells is essentially dependent on monocytes. IL-22 increase antimicrobial proteins (AMPs) in airway epithelium. EPs® 7630 might protect against airway infection by induction of AMP-inducers.