cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In vitro efficacy of essential oils against various Candida species
Creators: name: Saada, Alix
name: Monpierre, Lorra
name: Djènontin, Elie
name: Andriantsoanirina, Valérie
name: Ratsimbason, Michel
name: Randriamialinoro, Faliarivony
name: Ranarivelo, Lalasoanirina
name: Botterel, Françoise
name: Durand, Rémy
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Candida species are responsible for the most common fungal infections worldwide. We studied the in vitro antifungal activity of a large panel of essential oils (EOs) against various Candida species. The EOs activity against Candida spp. was tested using a gradient microdilution assay ranging from 4% to 0.008% (v/v). After a preliminary screening including 31 EOs, seven selected EOs were tested against 13 clinical isolates and four reference strains belonging to six Candida species. Cinnamomum zeylanicum and Cymbopogon giganteus EOs exhibited the best antifungal activity against all clinical and reference strains, with MIC ranges of 0.015%–0.25% (v/v). EOs from Litsea citrata, Backhousia citriodora and Ocimum sanctum presented MIC ranges of 0.03%–0.5% (v/v). The antifungal efficacy of EOs was independent of the susceptibility of Candida strains to usual antifungal agents. These EOs could have a promising antifungal action.
EKONOMETRIKADA INNOVATSIYALARNI MOLIYALASHTIRISH MEXANIZMI.
Creators: name: Kunakova, Fotima
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola innovatsiyalar va iqtisodiy o'sish o'rtasidagi bog'lanishni tahlil qiladi. Innovatsiyalar, yangi g'oya, mahsulot, xizmat yoki jarayonlarni yaratish jarayoni sifatida, iqtisodiy rivojlanishni rag'batlantiruvchi asosiy omil sifatida ko'rib chiqiladi. Maqolada innovatsiyalarning iqtisodiy o'sishga ta'siri, ularning turli turlari (mahsulot, jarayon, marketing va tashkiliy innovatsiyalar) va iqtisodiy model va statistik ma'lumotlardan foydalanish orqali qanday o'rganilishi haqida ma'lumot beriladi. Shuningdek, maqolada innovatsiyalar yordamida mahsuldorlikni oshirish, yangi ish o'rinlari yaratish va iste'molchilar ehtiyojlarini qondirish kabi muhim jihatlar ko'rib chiqiladi. Ekonometrik tahlil usullari, jumladan regressiya tahlili va panel ma'lumotlar, innovatsiyalarning iqtisodiy ko'rsatkichlarga ta'sirini aniqlashda qo'llaniladi. Maqola davlat va xususiy sektorning innovatsiyalarni qo'llab-quvvatlashdagi roli va innovatsiyalarni rag'batlantirish orqali iqtisodiy o'sishni kuchaytirish imkoniyatlarini taqdim etadi. Umuman olganda, innovatsiyalar iqtisodiy o'sishni rag'batlantiruvchi kuch sifatida e'tirof etiladi va ularning rivojlanishini qo'llab-quvvatlash iqtisodiy barqarorlik va farovonlikni ta'minlashda muhim ahamiyatga ega.
Myrcia amshoffae A. R. Lourenco & E. Lucas
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Myrtales
Myrtaceae
Myrcia
Myrcia amshoffae

description: [1280] Myrcia amshoffae (McVaugh) A.R.Lourenço & E.Lucas
 Phytotaxa 373 (1): 73 [23 Oct. 2018] (Lourenço & Lucas 2018). — Calyptranthes amshoffae McVaugh, Mem. New York Bot. Gard. 10 (1): 70 (McVaugh 1958).
NOTE. — Known only from the Guiana Shield.
VERNACULAR NAMES. — Wp: pila lea.
 HERBARIUM DATA (FG). — 10 collections at CAY. Sel. exs.: D. Larpin 846.
INVENTORY DATA (FG). — 6 trees in 2 plots; Fmax <1 %; dbhinv = 13.5 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 610, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Potential use of endophytic root bacteria and host plants to degrade hydrocarbons
Creators: name: Mitter, Eduardo K.
name: Kataoka, Ryota
name: J. Renato De Freitas
name: Germida, James J.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology

description: Microbe-assisted phytoremediation depends on competent root-associated microorganisms that enhance remediation efficiency of organic compounds. Endophytic bacteria are a key element of the root microbiome and may assist plant degradation of contaminants. The aim of this study was to investigate the application of four hydrocarbon-degrading endophytic strains previously isolated from an oil sands reclamation area. Strains EA1-17 (Stenotrophomonas sp.), EA2-30 (Flavobacterium sp.), EA4-40 (Pantoea sp.), and EA6-5 (Pseudomonas sp.) were inoculated in white sweet clover growing on soils amended with diesel at 5,000, 10,000, and 20,000 mg·kg−1. Our results indicate that plant growth inhibition caused by diesel fuel toxicity was overcome in inoculated plants, which showed significantly higher plant biomass. Analysis of soil F2 and F3 hydrocarbon fractions also revealed that these soils were remediated by inoculated plants when diesel was applied at 10,000 mg·kg−1 and 20,000 mg·kg−1. In addition, quantification of hydrocarbon-degrading genes suggests that all bacterial strains successfully colonized sweet clover plants. Overall, the endophytic strain EA6-5 (Pseudomonas sp.), which harbored hydrocarbon-degrading genes, was the most effective candidate in phytoremediation experiments and could be a strategy to increase plant tolerance and hydrocarbon degradation in contaminated (e.g., diesel fuel) soils.
Some Stable Difference Schemes to Describe the Flow in the Combined Region
Creators: name: U. Dalabaev
Publisher: name: Zenodo
Year: 2021
Subjects: Two phase medium
interpenetrating model
difference scheme
energy estimation
Darcy
Brinkman model

description: In many environmental, industrial and biological processes, flows occur in a saturated porous fluid medium. The transport of substances between surface water and groundwater is a very serious problem. The basis of the mathematical model is based on the interpenetrating model (Rahmatullin model) of two-phase media. The proposed equations make it possible to study the flow of a liquid in and outside the porous region in a uniform manner. In this case, the Navier-Stokes equation is obtained in the liquid region. In the porous region, the equations are close to the Brinkman model. In connection with the description of the flow from the standpoint of a single equation for the entire region, there is no need to set boundary conditions in the separation region (such as Beavers – Joseph – Saffman). Cross-border conditions arise if the energy estimation is used for the porous region. In this case, the order of the systems of equations in each area is different. On the basis of the proposed model, the energy estimation for the equation of Rahmatullin is derived using energy inequalities. The difference scheme of the equation of Rahmatullin is constructed and the stability of the constructed scheme is obtained.
Rogue Quantum Harmonic Oscillations
Creators: name: Bayindir, Cihan A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We show the existence and investigate the dynamics and statistics of rogue oscillations (standing waves) generated in the frame of the nonlinear quantum harmonic oscillator (NQHO). With this motivation, in this paper, we develop a split-step Fourier scheme for the computational analysis of NQHO. We show that modulation instability excites the generation of rogue oscillations in the frame of the NQHO. We also discuss the effects of various parameters such as the strength of trapping well potential, nonlinearity, dissipation, fundamental wave number and perturbation amplitude on rogue oscillation formation probabilities.
Different scoring systems to predict 6-week mortality in cirrhosis patients with acute variceal bleeding: a retrospective analysis of 202 patients
Creators: name: Wang, Fang
name: Cui, Shu
name: Wang, Fengmei
name: Li, Fenghui
name: Tang, Fei
name: Zhang, Xu
name: Gao, Yanying
name: Lv, Hongmin
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Objective: Determine the optimal scoring system for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with acute variceal bleeding (AVB). Prediction effects of six scoring systems, AIMS65 score, Glasgow-Blatchford (GBS) score, full Rockall (FRS) score, the model for end-stage liver disease (MELD), the MELD-Na model and the Child-Turcotte-Pugh (CTP) score were analyzed in this study. Methods: A total of 202 liver cirrhosis patients with AVB were enrolled between 1 January 2014, and 31 December 2014. All subjects were scored according to AIMS65, GBS, FRS, MELD, MELD-Na and CTP scoring systems on the first day of admission. The primary endpoint of the study was 6-week mortality. The prediction effect of these scoring systems for 6-week mortality was compared by ROC curve and the area under the curve (AUC). Results: The scores of nonsurvival group evaluated by the AIMS65, GBS, FRS, MELD, MELD-Na and CTP (2.6 ± 1.1, 12.9 ± 2.7, 6.6 ± 1.8, 26.9 ± 6.5, 31.6 ± 9.3, 9.6 ± 2.2, respectively) were higher than those of the survival group (1.2 ± 1.1, 10.2 ± 3.4, 5.1 ± 1.6, 21.0 ± 6.4, 22.8 ± 8.2, 7.7 ± 2.0, respectively) (p < .01). The values of AUC and Youden index of AIMS65 and MELD-Na scoring systems [(0.808, 0.453) and (0.781, 0.516), respectively] were superior to those of MELD (0.761, 0.454), CTP (0.748, 0.399), FRS (0.738, 0.358) and GBS scoring systems (0.726, 0.370). Conclusions: AIMS65 and MELD-Na scoring systems are recommended for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with AVB.
Diagonal Ladders: A New Class of Models for Strongly Coupled Electron Systems
Creators: name: Sierra, G.
name: Martin-Delgado, M. A.
name: White, S. R.
name: Scalapino, D. J.
name: Dukelsky, J.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We introduce a class of models defined on ladders with a diagonal structure generated by $n_p$ plaquettes. The case $n_p=1$ corresponds to the necklace ladder and has remarkable properties which are studied using DMRG and recurrent variational ansatzes. The AF Heisenberg model on this ladder is equivalent to the alternating spin-1/spin-1/2 AFH chain which is known to have a ferrimagnetic ground state (GS). For doping 1/3 the GS is a fully doped (1,1) stripe with the holes located mostly along the principal diagonal while the minor diagonals are occupied by spin singlets. This state can be seen as a Mott insulator of localized Cooper pairs on the plaquettes. A physical picture of our results is provided by a $t_p-J_p$ model of plaquettes coupled diagonally with a hopping parameter $t_d$. In the limit $t_d \to \infty$ we recover the original $t-J$ model on the necklace ladder while for weak hopping parameter the model is easily solvable. The GS in the strong hopping regime is essentially an "on link" Gutzwiller projection of the weak hopping GS. We generalize the $t_p-J_p-t_d$ model to diagonal ladders with $n_p >1$ and the 2D square lattice. We use in our construction concepts familiar in Statistical Mechanics as medial graphs and Bratelli diagrams.
description: REVTEX file, 22 pages (twocolumn), 35 figures inserted in text. 12 Tables
UTILIZING MODERN TEACHING METHODS FOR LANGUAGE INSTRUCTION IN PRIMARY EDUCATION
Creators: name: Umirzokov Sharofiddin
Publisher: name: Zenodo
Year: 2024

description: ANNOTATION: Children to strengthen their interest in being different from the first study on the subject's imagination, diligence, perseverance, lucidity, as an aspect of activity to overestimate the role and importance of preschool education institutions.                                                                                                          

KEY WORDS: Strengthen, subject's imagination, diligence, perseverance, lucidity, preschool education, technologies, preparatory schools, elementary schools, tier system.
A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia.
Creators: name: Furse, Samuel
name: Twinn, Denise
name: Beeson, Jessica H
name: Chiarugi, Davide
name: Ozanne, Susan E
name: Koulman, Albert
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/92/608
/692/163/2743/137/1926
/64/60
article

description: Funder: BHF, FS/14/59/31282
description: BACKGROUND: Gestational diabetes is associated with increased risk of type 2 diabetes mellitus and cardiovascular disease for the mother in the decade after delivery. However, the molecular mechanisms that drive these effects are unknown. Recent studies in humans have shown that lipid metabolism is dysregulated before diagnosis of and during gestational diabetes and we have shown previously that lipid metabolism is also altered in obese female mice before, during and after pregnancy. These observations led us to the hypothesis that this persistent dysregulation reflects an altered control of lipid distribution throughout the organism. METHODS: We tested this in post-weaning (PW) dams using our established mouse model of obese GDM (high fat, high sugar, obesogenic diet) and an updated purpose-built computational tool for plotting the distribution of lipid variables throughout the maternal system (Lipid Traffic Analysis v2.3). RESULTS: This network analysis showed that unlike hyperglycaemia, lipid distribution and traffic do not return to normal after pregnancy in obese mouse dams. A greater range of phosphatidylcholines was found throughout the lean compared to obese post-weaning dams. A range of triglycerides that were found in the hearts of lean post-weaning dams were only found in the livers of obese post-weaning dams and the abundance of odd-chain FA-containing lipids differed locally in the two groups. We have therefore shown that the control of lipid distribution changed for several metabolic pathways, with evidence for changes to the regulation of phospholipid biosynthesis and FA distribution, in a number of tissues. CONCLUSIONS: We conclude that the control of lipid metabolism is altered following an obese pregnancy. These results support the hypothesis that obese dams that developed GDM maintain dysregulated lipid metabolism after pregnancy even when glycaemia returned to normal, and that these alterations could contribute to the increased risk of later type 2 diabetes and cardiovascular disease.
Myrcia attenuata M. F. Santos
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Myrtales
Myrtaceae
Myrcia
Myrcia attenuata

description: [1281] Myrcia attenuata M.F.Santos
 Phytotaxa 234 (2): 163 (Santos 2015).
 HERBARIUM DATA (FG). — 2 collections at CAY. Sel. exs.: J.-J. de Granville et al. 6503 (holo-, B, not seen; iso-, BR [BR0000013176433], CAY [CAY097245], P [P05233192]); R. A. A. Oldeman T-650 [paratype], 25 m × 20 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 610, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Math for the Benefit of Society: A New MATLAB-Based Gen-Ed Course
Creators: name: Isihara, Paul
name: Townsend, Edwin
name: Ndkezi, Richard
name: Tully, Kevin
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology

description: Responding to a call for national reform of mathematical education, as well as a college-wide revision of general education (GE) requirements, we describe a new entry-level, GE course focused on the humanitarian utility of mathematics. This includes a detailed overview of how we taught the course using a Humanitarian MATLAB Lab Manual developed collaboratively with undergraduate students within an applied math program. A PRIMUS edition of this manual with complete MATLAB materials for a GE course is included as an Appendix for interested readers. A variety of social justice issues including peace-building after modern civil wars, continued cancer risk after Chernobyl, gang reduction, various dimensions of human trafficking, the use of a tractor and herbicide in subsistence farming, equitable resource distribution during the Syrian refugee crisis, and access to HIV vaccines are included in this special edition of the manual.
Orientational Ordering in Sequence-Disordered Liquid Crystalline Polymers
Creators: name: Gutman, L.
name: Shakhnovich, E. I.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Phase separation of sequence-disordered liquid crystalline polymers, a promising class of technological and biological relevance, is studied by field theory, and thermodynamic mechanisms responsible for orientational ordering observed in experiments, are discussed. The theory developed predicts that chemical disorder marginally affects the nematic/isotropic biphasic coexistence width, but strongly impacts ordering; above a critical chemical disorder threshold orientational ordering is precluded.
description: 4 pages, 5 figures
Unitary representations of SW(3/2,2) superconformal algebra
Creators: name: Gepner, Doron
name: Noyvert, Boris
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: SW(3/2,2) superconformal algebra is W algebra with two Virasoro operators. The Kac determinant is calculated and the complete list of unitary representations is determined. Two types of extensions of SW(3/2,2) algebra are discussed. A new approach to construction of W algebras from rational conformal field theories is proposed.
description: latex2e, 37 pages, 2 figures; v2: published version, introduction extended
Myrcia bracteata DC.
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Myrtales
Myrtaceae
Myrcia
Myrcia bracteata

description: [1282]  Myrcia bracteata  (Rich.) DC.
(Fig. 42C)
 Prodr. [A. P. de Candolle] 3: 245 [mid Mar. 1828] (Candolle 1828). — Eugenia bracteata Rich., Actes Soc. Hist. Nat. Paris 1: 110 [Oct. 1792] (Richard 1792). — Myrtus bracteata Mart. ex DC., Prodr. [A. P. de Candolle] 3: 245 [mid Mar. 1828] (Candolle 1828), nom. nud. pro syn.
 Myrcia lanceolata Cambess., Fl. Bras. Merid. [A. St.-Hil.] (quarto ed.) 2 (19): 329 [“1829” publ. 27 Oct. 1832] (Cambessèdes 1832).
 Myrcia lanceolata var. angustifolia Cambess., Fl. Bras. Merid. [A. St.-Hil.] (quarto ed.) 2 (19): 329 [“1829” publ. 27 Oct. 1832] (Cambessèdes 1832).
 Myrcia lanceolata var. grandifolia O.Berg, Fl. Bras. [Martius] 14 (1): 155 [15 May 1857] (Berg 1857).
 Myrcia lanceolata var. latifolia O.Berg, Fl. Bras. [Martius] 14 (1): 155 [15 May 1857] (Berg 1857).
 Myrcia lanceolata var. avenia O.Berg, Fl. Bras. [Martius] 14 (1): 156 [15 May 1857] (Berg 1857).
 Myrcia lanceolata var. racemosa O.Berg, Fl. Bras. [Martius] 14 (1): 156 [15 May 1857] (Berg 1857).
 Myrcia hirtellifolia Gleason, Bull. Torrey Bot. Club 58 (7): 411 [Oct. 1931] (Gleason 1931), “ hirtellaefolia ”.
 Eugenia hirsuta Ruiz & Pav., Anales Inst. Bot. Cavanilles 15: 220 (Ruiz & Pavón 1958).
VERNACULAR NAMES. — Pa: arak-priyu, kagegut, kagegut-ahavukune, kagegut-puvemna, karegut • Wp: kumesi sili, pikɨ lɨ sili, pila lea • Cr: koumaté • Br: cumaté, murtinha.
 HERBARIUM DATA (FG). — 50 collections at CAY.Sel. exs.: J.B.Leblond 110 (original material BR[BR0000005238668], G[G00223176]).
 SIZE. — Ecuador. C. Kajekai 356 (MO), 10 m.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on pages 610-611, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Structure of Electrorheological Fluids
Creators: name: Dassanayake, U.
name: Fraden, S.
name: van Blaaderen, A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Specially synthesized silica colloidal spheres with fluorescent cores were used as model electrorheological fluids to experimentally explore structure formation and evolution under conditions of no shear. Using Confocal Scanning Laser Microscopy we measured the location of each colloid in three dimensions. We observed an equilibrium body-centered tetragonal phase and several non-equilibrium structures such as sheet-like labyrinths and isolated chains of colloids. The formation of non-equilibrium structures was studied as a function of the volume fraction, electric field strength and starting configuration of the colloid. We compare our observations to previous experiments, simulations and calculations.
description: Revised figures included in this version. See related webpage: http://www.elsie.brandeis.edu
Evolution of enhanced innate immune evasion by SARS-CoV-2.
Creators: name: Thorne, Lucy G
name: Bouhaddou, Mehdi
name: Reuschl, Ann-Kathrin
name: Zuliani-Alvarez, Lorena
name: Polacco, Ben
name: Pelin, Adrian
name: Batra, Jyoti
name: Whelan, Matthew
name: Hosmillo, Myra
name: Fossati, Andrea
name: Ragazzini, Roberta
name: Jungreis, Irwin
name: Ummadi, Manisha
name: Rojc, Ajda
name: Turner, Jane
name: Bischof, Marie L
name: Obernier, Kirsten
name: Braberg, Hannes
name: Soucheray, Margaret
name: Richards, Alicia
name: Chen, Kuei-Ho
name: Harjai, Bhavya
name: Memon, Danish
name: Hiatt, Joseph
name: Rosales, Romel
name: McGovern, Briana L
name: Jahun, Aminu
name: Fabius, Jacqueline M
name: White, Kris
name: Goodfellow, Ian
name: Takeuchi, Yasu
name: Bonfanti, Paola
name: Shokat, Kevan
name: Jura, Natalia
name: Verba, Klim
name: Noursadeghi, Mahdad
name: Beltrao, Pedro
name: Kellis, Manolis
name: Swaney, Danielle L
name: García-Sastre, Adolfo
name: Jolly, Clare
name: Towers, Greg J
name: Krogan, Nevan J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/326/596/4130
/631/553
/82/58
article

description: The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission1,2. Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of spike are likely to contribute to adaptation. Here, using unbiased abundance proteomics, phosphoproteomics, RNA sequencing and viral replication assays, we show that isolates of the Alpha (B.1.1.7) variant3 suppress innate immune responses in airway epithelial cells more effectively than first-wave isolates. We found that the Alpha variant has markedly increased subgenomic RNA and protein levels of the nucleocapsid protein (N), Orf9b and Orf6-all known innate immune antagonists. Expression of Orf9b alone suppressed the innate immune response through interaction with TOM70, a mitochondrial protein that is required for activation of the RNA-sensing adaptor MAVS. Moreover, the activity of Orf9b and its association with TOM70 was regulated by phosphorylation. We propose that more effective innate immune suppression, through enhanced expression of specific viral antagonist proteins, increases the likelihood of successful transmission of the Alpha variant, and may increase in vivo replication and duration of infection4. The importance of mutations outside the spike coding region in the adaptation of SARS-CoV-2 to humans is underscored by the observation that similar mutations exist in the N and Orf9b regulatory regions of the Delta and Omicron variants.
title: Studium und Praxis Plus (SUP+) - Innovative Integration von Akademischer Ausbildung und beruflicher Praxis
Creators: name: Rüsssmeier, Nick
name: Haupt, Matthias
Publisher: name: twillo
Year: 2024
Subjects: classificationCode: 2
subject: FOS: Engineering and technology

description: Die Veröffentlichung zur Projektvorstellung im Rahmen der Abschlusstagung zur Förderlinie "Innovation Plus" am 7. und 8. März 2024 in Hannover
Inhaltliche Darstellung des Projektes STUDIUM UND PRAXIS PLUS (SUP+) -INNOVATIVE INTEGRATION VON AKADEMISCHER AUSBILDUNG UND BERUFLICHER PRAXIS.
Der Innovationscharakter des Projektes „Studium und Praxis plus“ lag in der Einführung von neuen didaktischen Konzepten zur besseren Wissensvermittlung im direkten Austausch von Studierenden höherer Semester mit denen niedrigerer Semester. Hierzu wurden Blended
Learning Inhalte zur Selbstreflexion, Selbstorganisation und zum kooperativen Lernen erarbeitet. Dieser neue Ansatz zur Etablierung einer praxisbezogenen Wissensvermittlung betrifft die meisten Bachelor-Studiengänge des Fachbereichs Ingenieurwissenschaften. Dabei spielte die
Digitalisierung des Prozesses eine entscheidende Rolle, da die Studierenden gerade im betrieblichen Teil des Praxissemesters meist über die ganze Welt verteilt sind und so ein Austausch ohne eine entsprechende digitale Plattform nicht denkbar ist. Es sollten daher hybride Lernsettings und Angebote zu Workshops erarbeitet werden.
Mit dem Projekt wurden zusammenfassend folgende Felder adressiert:
– Einführung neuer hochschuldidaktischer Konzepte und Maßnahmen
– Stärkung des Praxisbezugs in grundständigen Studiengängen
– Verbesserung der Lehre durch Digitalisierung
– Förderung der Kommunikation und Zusammenarbeit von Studierenden (Kollaboratives Lernen)

Gefördert im Rahmen des Programms „Innovation plus" für innovative Lehr- und Lernkonzepte des Niedersächsischen Ministerium für Wissenschaft und Kultur. Fördernummer. 041
An alternative stable solution for the Kepler-419 system, obtained with the use of a genetic algorithm
Creators: name: Carpintero, D. D.
name: Melita, M. D.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The mid-transit times of an exoplanet may be non-periodic. The variations in the timing of the transits with respect to a single period, that is, the transit timing variations (TTVs), can sometimes be attributed to perturbations by other exoplanets present in the system, which may or may not transit the star. Our aim is to compute the mass and the six orbital elements of an non-transiting exoplanet, given only the central times of transit of the transiting body. We also aim to recover the mass of the star and the mass and orbital elements of the transiting exoplanet, suitably modified in order to decrease the deviation between the observed and the computed transit times by as much as possible. We have applied our method, based on a genetic algorithm, to the Kepler-419 system. We were able to compute all fourteen free parameters of the system, which, when integrated in time, give transits within the observational errors. We also studied the dynamics and the long-term orbital evolution of the Kepler-419 planetary system as defined by the orbital elements computed by us, in order to determine its stability.
description: 11 pages, 15 figures. A&A accepted. Typo corrected
Superconductivity in Ru0.55Rh0.45P and Ru0.75Rh0.25As probed by muon spin relaxation and rotation measurements
Creators: name: Anand, V. K.
name: Adroja, D. T.
name: Lees, M. R.
name: Biswas, P. K.
name: Hillier, A. D.
name: Lake, B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Superconductivity in the pseudo-binary pnictides Ru0.55Rh0.45P and Ru0.75Rh0.25As is probed by muon spin relaxation and rotation (muSR) measurements in conjuction with magnetic susceptibility, heat capacity and electrical resistivity measurements. Powder x-ray diffraction confirmed the MnP-type orthorhombic structure (space group Pnma) and showed a nearly single phase nature with small impurity phase(s) of about 5% for both the samples. The occurence of bulk superconductivity is confirmed with Tc = 3.7 K for Ru0.55Rh0.45P and T = 1.6 K for Ru0.75Rh0.25As. The superconducting state electronic heat capacity data reveal weak-coupling single-band isotropic s-wave gap BCS superconductivity. Various normal and superconducting state parameters are determined which reveal a weak-coupling electron-phonon driven type-II dirty-limit superconductivity for both the compounds. The upper critical field shows a linear temperature dependence down to the lowest measured temperatures which is quite unusual for a single-band superconductor. The muSR data confirm the conventional type-II behavior, and show evidence for a single-band s-wave singlet pairing superconductivity with a preserved time reversal symmetry for both the compounds.
description: 11 pages, 15 figures, 1 table, accepted for publication in PRB
Supplementary document for Realizing PIT-like transparency via the coupling of plasmonic dipole and ENZ modes - 5696146.pdf
Creators: name: Mao, Miao
name: Wang, junqiao
name: mu, Kaijun
name: Fan, Chunzhen
name: Jia, Yuanlin
name: Li, Ran
name: Chen, Shu
name: Liang, Erjun
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplemental Document
Direct Electrospinning of Cellulose Acetate onto Polyurethane Sheet and Effect of Its Saponification on Mechanical Properties
Creators: name: Md. Momotaz Ali
name: Nutthira Pakkang
name: Taira, Shogo
name: Koda, Keiichi
name: Itoyama, Koki
name: Uraki, Yasumitsu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: This article reports on direct electrospinning of water-soluble cellulose acetate (WSCA) and cellulose diacetate (CDA) onto a non-conductive synthetic polymer sheet such as polyurethane (PU) sheet to modify its surface morphology. The direct electrospinning was successfully performed after spraying an anti-static agent on the PU sheet. Furthermore, tight fixation of the fibers was achieved by spraying a dimethylformamide/ethanol (1/1) solution during the spinning. Finally, the cellulose acetate fibers on the PU sheet were converted to regenerated cellulose fibers by saponification. Changes in surface morphology were evaluated via tribology tests. The friction coefficient of the PU sheet significantly decreased with increases in the amount of deposited fiber, thereby suggesting that the PU sheet surface became smoother. After saponification, the friction coefficients of the sheets slightly increased, with the exception of the PU sheet with the increased amount of saponified WSCA fibers, and this was potentially attributed to changes in the elasticity upon saponification.
Myrcia gigas McVaugh
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Myrtales
Myrtaceae
Myrcia
Myrcia gigas

description: [1290] Myrcia gigas McVaugh
 Mem. New York Bot. Gard. 18 (2): 88 (McVaugh 1969).
 HERBARIUM DATA (FG). — 16 collections at CAY. Sel. exs.: S.A. Mori et al. 20960.
INVENTORY DATA (FG). — 1 tree, dbh = 10.5 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 612, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors.
Creators: name: Kasaragod, Vikram Babu
name: Mortensen, Martin
name: Hardwick, Steven
name: Wahid, Ayla
name: Dorovykh, Valentina
name: Chirgadze, Dima
name: Smart, Trevor G
name: Miller, Paul
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/378/2586
/631/378/340
/631/535/1258/1259
/9/74
/13/1
/13/106
/13/109
/82/80
/82/83
/101/28
article

description: Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits1. αβ, α4βδ, α6βδ and α5βγ receptors favour extrasynaptic localization, and mediate an essential persistent (tonic) inhibitory conductance in many regions of the mammalian brain1,2. Mutations of these receptors in humans are linked to epilepsy and insomnia3,4. Altered extrasynaptic receptor function is implicated in insomnia, stroke and Angelman and Fragile X syndromes1,5, and drugs targeting these receptors are used to treat postpartum depression6. Tonic GABAergic responses are moderated to avoid excessive suppression of neuronal communication, and can exhibit high sensitivity to Zn2+ blockade, in contrast to synapse-preferring α1βγ, α2βγ and α3βγ receptor responses5,7-12. Here, to resolve these distinctive features, we determined structures of the predominantly extrasynaptic αβ GABAA receptor class. An inhibited state bound by both the lethal paralysing agent α-cobratoxin13 and Zn2+ was used in comparisons with GABA-Zn2+ and GABA-bound structures. Zn2+ nullifies the GABA response by non-competitively plugging the extracellular end of the pore to block chloride conductance. In the absence of Zn2+, the GABA signalling response initially follows the canonical route until it reaches the pore. In contrast to synaptic GABAA receptors, expansion of the midway pore activation gate is limited and it remains closed, reflecting the intrinsic low efficacy that characterizes the extrasynaptic receptor. Overall, this study explains distinct traits adopted by αβ receptors that adapt them to a role in tonic signalling.
description: This work was supported by a Department of Pharmacology new lab start-up fund, the University of Cambridge Isaac Newton & Wellcome Trust Institutional Strategic Support Fund, and Academy of Medical Sciences Springboard Award (SBF004\1074). Electrophysiology work in the laboratory of Professor Trevor Smart was funded by an MRC programme grant (MR/T002581/1) and Wellcome Trust Collaborative Award (217199/Z/19/Z). The cryo-EM facility receives funding from the Wellcome Trust (206171/Z/17/Z; 202905/Z/16/Z) and University of Cambridge.
Spin-Blockade in Single and Double Quantum Dots in Magnetic Fields: a Correlation Effect
Creators: name: Imamura, Hiroshi
name: Aoki, Hideo
name: Maksym, Peter A.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The total spin of correlated electrons in a quantum dot changes with magnetic field and this effect is generally linked to the change in the total angular momentum from one magic number to another, which can be understood in terms of an `electron molecule' picture for strong fields. Here we propose to exploit this fact to realize a spin blockade, i.e., electrons are prohibited to tunnel at specific values of the magnetic field. The spin-blockade regions have been obtained by calculating both the ground and excited states. In double dots the spin-blockade condition is found to be less stringent than in single dots.
description: 4pages, to be published in Phys. Rev. B (Rapid Communication)
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Creators: name: Rebelo-Guiomar, Pedro
name: Pellegrino, Simone
name: Dent, Kyle C
name: Sas-Chen, Aldema
name: Miller-Fleming, Leonor
name: Garone, Caterina
name: Van Haute, Lindsey
name: Rogan, Jack F
name: Dinan, Adam
name: Firth, Andrew
name: Andrews, Byron
name: Whitworth, Alex
name: Schwartz, Schraga
name: Warren, Alan
name: Minczuk, Michal
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/45/500
/631/535/1258/1259
/631/337/1645
/631/80/642/333
/631/337/574/1789
/101
/101/28
/101/58
/38
/38/91
/38/77
/13
/64
/64/24
article

description: Funder: Kay Kendall Leukaemia Fund (KKLF); doi: https://doi.org/10.13039/501100000402
description: Funder: EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme "People" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011264; Grant(s): Mitobiopath-705560
description: Many cellular processes, including ribosome biogenesis, are regulated through post-transcriptional RNA modifications. Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'-O-methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. MRM2 controls mitochondrial respiration by regulating mitoribosome biogenesis. In its absence, mtLSU particles (visualized by cryo-EM at the resolution of 2.6 Å) present disordered RNA domains, partial occupancy of bL36m and bound MALSU1:L0R8F8:mtACP anti-association module, allowing five mtLSU biogenesis intermediates with different intersubunit interface configurations to be placed along the assembly pathway. However, mitoribosome biogenesis does not depend on the methyltransferase activity of MRM2. Disruption of the MRM2 Drosophila melanogaster orthologue leads to mitochondria-related developmental arrest. This work identifies a key checkpoint during mtLSU assembly, essential to maintain mitochondrial homeostasis.
Collective intersubband transitions in quantum wells: a comparative density-functional study
Creators: name: Ullrich, C. A.
name: Vignale, G.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We use time-dependent (current) density functional theory to study collective transitions between the two lowest subbands in GaAs/AlGaAs quantum wells. We focus on two systems where experimental results are available: a wide single and a narrow asymmetric double well. The aim is to calculate frequency and linewidth of collective electronic modes damped via electron-electron interaction only. Since Landau damping is not effective here, the dominant damping mechanism involves dynamical exchange-correlation effects such as multipair production. To capture these effects, one has to go beyond the widely used adiabatic local density approximation (ALDA) and include retardation. We perform a comparative study of two approaches which fall in this category: the dynamical extension of the ALDA by Gross and Kohn, and a more recent method which treats exchange and correlation beyond the ALDA as viscoelastic stresses in the electron liquid. We find that the former method is more robust: it performs similarly for strongly different degrees of collectivity of the electronic motion. Results for quantum wells compare reasonably to experiment, with a tendency towards overdamping. By contrast, the viscoelastic approach is superior for systems where the electron dynamics is predominantly collective, but breaks down if the local velocity field is too rapidly varying, as in the case of a single-electron-like behavior such as tunneling through a potential barrier.
description: 23 pages, 6 ps-figures, revtex
Optimal Investment to Enable Evolutionary Rescue
Creators: name: Ashander, Jaime
name: Thompson, Lisa C.
name: Sanchirico, James N.
name: Baskett, Marissa L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: 'Evolutionary rescue' is the potential for evolution to enable population persistence in a changing environment. Even with eventual rescue, evolutionary time lags can cause the population size to temporarily fall below a threshold susceptible to extinction. To reduce extinction risk given human-driven global change, conservation management can enhance populations through actions such as captive breeding. To quantify the optimal timing of, and indicators for engaging in, investment in temporary enhancement to enable evolutionary rescue, we construct a model of coupled demographic-genetic dynamics given a moving optimum. We assume 'decelerating change', as might be relevant to climate change, where the rate of environmental change initially exceeds a rate where evolutionary rescue is possible, but eventually slows. We analyze the optimal control path of an intervention to avoid the population size falling below a threshold susceptible to extinction, minimizing costs. We find that the optimal path of intervention initially increases as the population declines, then declines and ceases when the population growth rate becomes positive, which lags the stabilization in environmental change. In other words, the optimal strategy involves increasing investment even in the face of a declining population, and positive population growth could serve as a signal to end the intervention. In addition, a greater carrying capacity relative to the initial population size decreases the optimal intervention. Therefore, a one-time action to increase carrying capacity, such as habitat restoration, can reduce the amount and duration of longer-term investment in population enhancement, even if the population is initially lower than and declining away from the new carrying capacity.
Regional Haemodynamic and Metabolic Coupling in Infants.
Creators: name: Siddiqui, Maheen F
name: Pinti, Paola
name: Lloyd-Fox, Sarah
name: Jones, Emily JH
name: Brigadoi, Sabrina
name: Collins-Jones, Liam
name: Tachtsidis, Ilias
name: Johnson, Mark H
name: Elwell, Clare E
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Human Neuroscience
metabolism
fNIRS (functional near infrared spectroscopy)
neurovascular coupling
brain specialization
neurodevelopment
mitochondria
social brain
brain metabolic imaging

description: Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy (bNIRS) provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase (ΔoxCCO) alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy.
Myrcia minutiflora Sagot
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Myrtales
Myrtaceae
Myrcia
Myrcia minutiflora

description: [1294] Myrcia minutiflora Sagot
 Ann. Sci. Nat., Bot. sér. 6, 20: 185 (Sagot 1885). — Aulomyrcia minutiflora (Sagot) Amshoff, Bull. Torrey Bot. Club 75 (5): 532 [11 Oct. 1948] (Amshoff 1948).
VERNACULAR NAMES. — Wp: wɨla wasey.
 HERBARIUM DATA (FG). — 26 collections at CAY. Sel. exs.: E.M. Mélinon 442 (original material P[P00163092]).
SIZE. — Up to 10 m tall (Holst 2003).
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 616, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777