cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On internal structure of smaller domains in domain coarsening dynamics of spontaneous Z_2-symmetry breaking in two dimensions
Creators: name: Takeuchi, Hiromitsu
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The internal structure of domains smaller than the characteristic size in domain coarsening dynamics of $Z_2$ symmetry breaking is evaluated theoretically for different phase ordering systems in two dimensions. In the previous works on (non-) conserved Ising systems and binary superfluids, the statistical properties of smaller domains are analyzed by assuming that the contribution from its internal structure is negligible. It is shown that this assumption is justified analytically with respect to the statistical quantities, such as domain area, domain-wall length and superfluid circulation, according to the empirical dynamic scaling law for the smaller domains.
description: 7 pages, 1 figure
Compositional boundary layers trigger liquid unmixing in a basaltic crystal mush
Creators: name: Honour, Victoria C.
name: Holness, Marian B.
name: Charlier, Bernard
name: Piazolo, Sandra C.
name: Namur, Olivier
name: Prosa, Ty J.
name: Martin, Isabelle
name: Helz, Rosalind T.
name: Maclennan, John
name: Jean, Marlon M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/704/2151/209
/704/2151/213
/704/2151/431
/704/2151/598
/147
/147/28
/147/135
/147/136
/147/3
/132
/123
article

description: Abstract: The separation of immiscible liquids has significant implications for magma evolution and the formation of magmatic ore deposits. We combine high-resolution imaging and electron probe microanalysis with the first use of atom probe tomography on tholeiitic basaltic glass from Hawaii, the Snake River Plain, and Iceland, to investigate the onset of unmixing of basaltic liquids into Fe-rich and Si-rich conjugates. We examine the relationships between unmixing and crystal growth, and the evolution of a nanoemulsion in a crystal mush. We identify the previously unrecognised role played by compositional boundary layers in promoting unmixing around growing crystals at melt-crystal interfaces. Our findings have important implications for the formation of immiscible liquid in a crystal mush, the interpretations of compositional zoning in crystals, and the role of liquid immiscibility in controlling magma physical properties.
Exploring antibiofilm potential of some new imidazole analogs against C. albicans: synthesis, antifungal activity, molecular docking and molecular dynamics studies
Creators: name: Pathan, Shahebaaz K.
name: Shelar, Amruta
name: Deshmukh, Satish
name: Khan, Firoz A. Kalam
name: Ansari, Siddique Akber
name: Ansari, Irfan Aamer
name: Patil, Rajesh B.
name: Arote, Rohidas
name: Bhusnure, Omprakash
name: Patil, Rajendra H.
name: Sangshetti, Jaiprakash N.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: A series of 1, 2, 4, 5-tetrasubstituted imidazole derivatives were synthesized and their antibiofilm potential against Candida albicans was evaluated in vitro. Two of the synthesized derivatives 5e (IC50 = 25 µg/mL) and 5m (IC50 = 6 µg/mL),displayed better antifungal and antibiofilm potential than the standard drug Fluconazole (IC50 = 40 µg/mL) against C. albicans. Based on the in vitro results, we escalated the real time polymerase chain reaction (RT-PCR) analysis to gain knowledge of the enzymes expressed in the generation and maintenance of biofilms and the mechanism of biofilm inhibition by the synthesized analogues. We then investigated the possible interactions of the synthesized compounds in inhibiting agglutinin-like proteins, namely Als3, Als4 and Als6 were prominently down-regulated using in-silico molecular docking analysis against the previously available crystal structure of Als3 and constructed structure of Als4 and Als6 using the SWISS-MODEL server. The stability and energy of the agglutinin-like proteins–ligand complexes were evaluated using molecular dynamics simulations (MDS). According to the 100 ns MDS, all the compounds remained stable, formed a maximum of 3, and on average 2 hydrogen bonds, and Gibb’s free energy landscape analysis suggested greater affinity of the compounds 5e and 5m toward Als4 protein.
Fremanezumab in the prevention of migraine: a profile of its use
Creators: name: Lamb, Yvette
Publisher: name: Adis Journals
Year: 2019
Subjects: subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Compliance with ethical standards
 Funding: The preparation of this review was not supported by any external funding.
 Conflicts of interest: Y. N. Lamb is a salaried employee of Adis International Ltd./Springer Nature, is responsible for the article content and declares no conflicts of interest.
Additional information about this Adis Drug Review can be found here
Abstract
Fremanezumab (fremanezumab-vfrm; Ajovy®), a monoclonal antibody that targets calcitonin gene-related peptide (CGRP), is indicated for the prevention of migraine in adults in the EU and USA. Subcutaneous fremanezumab 225 mg once monthly or 675 mg once every 3 months was effective in reducing monthly migraine days or headache days in patients with episodic or chronic migraine in pivotal, 12-week clinical trials. Both regimens also reduce acute headache medication use and headache-related disability. Improvements were maintained through ≤ 52 weeks of additional treatment in a longer-term extension study. In a trial in treatment-resistant migraine, both fremanezumab regimens reduced monthly migraine days in patients who had failed 2–4 classes of preventive medications. Fremanezumab is generally well tolerated, with most adverse events (AEs) being injection site reactions of mild or moderate severity.

© Springer Nature Switzerland AG 2019
Liparogetus sulcatissimus Broun 1915
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Liparogetus
Liparogetus sulcatissimus

description: Liparogetus sulcatissimus Broun, 1915
 Liparogetus sulcatissimus Broun, 1915: 331 (type locality: New Zealand: Remarkables, near Queenstown, Otago; type material: H: BMNH).
 Distribution. New Zealand (Alonso-Zarazaga and Lyal, 1999).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 27, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Residual Symmetries in the Presence of an EM Background
Creators: name: Carrion, H. L.
name: Rojas, M.
name: Toppan, F.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The symmetry algebra of a QFT in the presence of an external EM background (named "residual symmetry") is investigated within a Lie-algebraic, model independent scheme. Some results previously encountered in the literature are here extended. In particular we compute the symmetry algebra for a constant EM background in D=3 and D=4 dimensions. In D= 3 dimensions the residual symmetry algebra is isomorphic to $u(1)\oplus {\cal P}_c(2)$, with ${\cal P}_c(2)$ the centrally extended 2-dimensional Poincaré algebra. In D=4 dimension the generic residual symmetry algebra is given by a seven-dimensional solvable Lie algebra which is explicitly computed. Residual symmetry algebras are also computed for specific non-constant EM backgrounds.
description: 11 pages, Latex
Introduction to $\mathrm{G}_2$ geometry
Creators: name: Karigiannis, Spiro
Publisher: name: arXiv
Year: 2019
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: These notes give an informal and leisurely introduction to $\mathrm{G}_2$ geometry for beginners. A special emphasis is placed on understanding the special linear algebraic structure in $7$ dimensions that is the pointwise model for $\mathrm{G}_2$ geometry, using the octonions. The basics of $\mathrm{G}_2$-structures are introduced, from a Riemannian geometric point of view, including a discussion of the torsion and its relation to curvature for a general $\mathrm{G}_2$-structure, as well as the connection to Riemannian holonomy. The history and properties of torsion-free $\mathrm{G}_2$ manifolds are considered, and we stress the similarities and differences with Kahler and Calabi-Yau manifolds. The notes end with a brief survey of three important theorems about compact torsion-free $\mathrm{G}_2$ manifolds.
description: 37 pages. To appear in a forthcoming volume of the Fields Institute Communications, entitled "Lectures and Surveys on G2 manifolds and related topics". Version 2: Corrected the references. No other changes
Additional file 1 of Epidemiological characterization of Clonorchis sinensis infection in humans and freshwater fish in Guangxi, China
Creators: name: Xie, Yihong
name: Kanankege, Kaushi S. T.
name: Jiang, Zhihua
name: Liu, Shun
name: Yang, Yichao
name: Wan, Xiaoling
name: Perez, Andres M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1: Table S1. AIC values of the model fits.
Regional institutions and competitiveness dynamics of typical and quality products in the new EU scenery
Creators: name: Montresor, Elisa
name: Mazzocchi, Mario
name: Zanchini, Alessandra
name: Montresor, Elisa
name: Mazzocchi, Mario
name: Zanchini, Alessandra
Publisher: name: Unknown
Year: 1999
Subjects: subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: Research Methods/ Statistical Methods
subject: rural development
subject: multivariate statistics
subject: regional policy

description: The aim of this work is to contribute to the definition of an analytical approach to evaluate the dynamics in progress in the agricultural and agro-food sector development at local and regional levels. Special care will be devoted to examining the role played by the regional Institutions in determining higher levels of competitiveness for typical and quality products in the new EU scenery. The auxiliary statistical methodology adopted here consists in cluster analysis preceded by principal components analysis. Starting from a wide set of indicators, which is assumed to be sufficient to describe the territorial system, the principal components analysis allows to synthesise such a set into a reduced number of uncorrelated components. The components are then utilised in the cluster analysis in order to identify the agricultural systems on the territory. Then, the relevance of typical and quality productions in each territorial system can be analysed. A case study on Emilia-Romagna region is presented. The region is characterised by a high level of development and an important agricultural productivity. This study mainly highlighted the role played by standard requirements of some typical and quality productions that enable to reach a higher competitiveness in the new national and European contexts. The role that the regional institutions will play is also examined throughout the paper. The function of public support, programming and developing initiatives at a local level is discussed.
Recommendations for hemodynamic monitoring for critically ill children—expert consensus statement issued by the cardiovascular dynamics section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)
Creators: name: Singh, Yogen
name: Villaescusa, Javier Urbano
name: Da Cruz, Eduardo M.
name: Tibby, Shane M.
name: Bottari, Gabriella
name: Saxena, Rohit
name: Guillén, Marga
name: Herce, Jesus Lopez
name: Di Nardo, Matteo
name: Cecchetti, Corrado
name: Brierley, Joe
name: De Boode, Willem
name: Lemson, Joris
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research
Hemodynamic monitoring (HD)
Paediatric intensive care unit (PICU)
Children
Cardiovascular instability
Recommendations

description: Abstract: Background: Cardiovascular instability is common in critically ill children. There is a scarcity of published high-quality studies to develop meaningful evidence-based hemodynamic monitoring guidelines and hence, with the exception of management of shock, currently there are no published guidelines for hemodynamic monitoring in children. The European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Cardiovascular Dynamics section aimed to provide expert consensus recommendations on hemodynamic monitoring in critically ill children. Methods: Creation of a panel of experts in cardiovascular hemodynamic assessment and hemodynamic monitoring and review of relevant literature—a literature search was performed, and recommendations were developed through discussions managed following a Quaker-based consensus technique and evaluating appropriateness using a modified blind RAND/UCLA voting method. The AGREE statement was followed to prepare this document. Results: Of 100 suggested recommendations across 12 subgroups concerning hemodynamic monitoring in critically ill children, 72 reached “strong agreement,” 20 “weak agreement,” and 2 had “no agreement.” Six statements were considered as redundant after rephrasing of statements following the first round of voting. The agreed 72 recommendations were then coalesced into 36 detailing four key areas of hemodynamic monitoring in the main manuscript. Due to a lack of published evidence to develop evidence-based guidelines, most of the recommendations are based upon expert consensus. Conclusions: These expert consensus-based recommendations may be used to guide clinical practice for hemodynamic monitoring in critically ill children, and they may serve as a basis for highlighting gaps in the knowledge base to guide further research in hemodynamic monitoring.
Monoterpenes as potential antifungal molecules against Candida cell membranes: in-vitro and in-silico studies
Creators: name: Raj, Nafis
name: Fakhri, Khalid Umar
name: Pathak, Prerna
name: Ahmedi, Saiema
name: Manzoor, Nikhat
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Azoles are the frequently used antifungal drugs that target the enzyme lanosterol 14 α-demethylase (erg11p). This enzyme plays a vital role in ergosterol biosynthesis and hence maintainenance of cell membrane fluidity and integrity. The emergence of resistance to azoles and their fungistatic nature against several fungal pathogens is the major challenge to combat invasive candidiasis. Therefore, there is an urgent need to discover new antifungals with better efficacy. This study targets erg11 protein using in silico approach and identifies the monoterpene compounds (α-terpineol, carveol, and terpinene-4-ol) based on docking score and ligand interaction analysis. Further dynamic behavior of best-docked compounds with erg11p was analyzed by various parameters of MD simulation. The binding free energy of selected compounds towards the definitive pocket was also calculated. To further investigate the antifungal activity of selected compounds, in vitro studies were conducted on C. albicans. Studies thus suggest that the proposed the mechanism of antifungal action of test compounds involves targeting the ergosterol biosynthetic pathway. The compounds were explored for their effect on the disruption of membrane integrity by studying ERG11gene expression analysis, scanning electron microscopy, PI uptake (fluorescence microscopy,) and H+-extrusion. The results suggest that the selected monoterpenes are safer natural antifungals that disrupt membrane integrity by inhibiting ergosterol biosynthesis and other membrane associated structures.
Red Giant Branch stars: the theoretical framework
Creators: name: Salaris, M.
name: Cassisi, S.
name: Weiss, A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Theoretical predictions of Red Giant Branch stars' effective temperatures, colors, luminosities and surface chemical abundances are a necessary tool for the astrophysical interpretation of the visible--near infrared integrated light from unresolved stellar populations, the Color-Magnitude-Diagrams of resolved stellar clusters and galaxies, and spectroscopic determinations of red giant chemical abundances. On the other hand, the comparison with empirical constraints provides a stringent test for the accuracy of present generations of red giant models. We review the current status of red giant stars' modelling, discussing in detail the still existing uncertainties affecting the model input physics (e.g., electron conduction opacity, treatment of the superadiabatic convection), and the adequacy of the physical assumptions built into the model computations. We compare theory with several observational features of the Red Giant Branch in galactic globular clusters, such as the luminosity function bump, the luminosity of the Red Giant Branch tip and the envelope chemical abundance patterns, to show the level of agreement between current stellar models and empirical data concerning the stellar luminosities, star counts, and surface chemical abundances.
description: 71 pages, 18 figures, PASP review (in press)
Listroderes Schonherr 1826
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listroderes

description: Listroderes Schönherr, 1826
 Listroderes Schönherr, 1823: col. 1142 (nom. nud.).
 Listroderes Schönherr, 1826: 158 (type species: L. costirostris Schönherr, 1826, by original designation, combined description); Germain, 1895: 464 (revision, Chile); Morrone, 1993c: 16 (revision, L. curvipes species group); Morrone, 1993d: 273 (revision, L. costirostris species group); Morrone, 1993e: 118 (revision, L. nodifer species group); Morrone, 1993f: 397 (phylogenetic analysis); Morrone, 1995b: 74 (revision, L. robustus species group).
 Listroderus Erichson, 1847: 129 (lapsus); Bruch, 1914: 414 (lapsus).
 Listoderes Kuschel, 1990: 71 (lapsus).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 28, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
A Spectral Characterization for Concentration of the Cover Time
Creators: name: Hermon, Jonathan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
Mixing times
Hitting times
Cover times
Vertex-transitive graphs
Spectral gap
60J10
60J27

description: Abstract: We prove that for a sequence of finite vertex-transitive graphs of increasing sizes, the cover times are asymptotically concentrated if and only if the product of the spectral gap and the expected cover time diverges. In fact, we prove this for general reversible Markov chains under the much weaker assumption (than transitivity) that the maximal hitting time of a state is of the same order as the average hitting time.
Economic organisation and territoriality within the wine industry of quality : a comparison between France and New Zealand
Creators: name: Moran, Waren
name: Perrier-Cornet, Philippe
name: Traversac, Jean Baptiste
name: Moran, Waren
name: Perrier-Cornet, Philippe
name: Traversac, Jean Baptiste
Publisher: name: Unknown
Year: 1999
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Institutional and Behavioral Economics
subject: Wine industry
subject: agrocommodity chain
subject: regulation
subject: territoriality
subject: Burgundy
subject: New Zealand

description: At first sight the wine industries of the countries of Europe and the New World use geographic space to create value in quite different ways. The French appellation system divides space in an intricate, hierarchical manner and regulates many of the actions of enterprises. In most New World countries, in contrast, rules about the naming of wines and viticultural and winemaking practices are much looser. Yet, when it comes to commercial practices and details of labelling, enterprises in the New World use territory in a range of ways to enhance their images and to manage their risks. Moreover, different forms of production, notably family producers and large corporations, relate to territory at different scales and in different ways. These practices are investigated by examining the geography of the commodity chains of winemaking enterprises in New Zealand and France (Burgundy} in relation to their local and regional environments. The use of different analytical perspectives - the enterprise and the territorial complex - to understand these agro-commodity chains is explored. This paper explores three themes from our initial interviews and data collection. The first is a description of the forms of territoriality of two central protagonists in the two contexts : the large corporation Montana in New Zealand, which plays a dominant role in the New Zealand"filiere" and the "negociants-eleveurs" in Burgundy. The second is the role of geographic indications and the professional organisations of the two regions in their territoriality and the third is to reflect on the convergence between France and New Zealand in the territorial behaviour of the participants in industries of the two countries.
Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
Creators: name: Firbank, Michael J.
name: O’Brien, John T.
name: Ritchie, Karen
name: Wells, Katie
name: Williams, Guy
name: Su, Li
name: Ritchie, Craig W.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original Communication
MRI
Alcohol
Mid-life
Brain volume
Longitudinal
Atrophy

description: Abstract: Background and aims: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects. Methods: A sample of 162 subjects (aged 40–59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM. Results: Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this. Conclusions: We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40–60-year-olds.
Crust Cooling Models are Insensitive to the Crust-Core Transition Pressure for Realistic Equations of State
Creators: name: Lalit, Sudhanva
name: Meisel, Zach
name: Brown, Edward F.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Neutron stars cooling after sustained accretion outbursts provide unique information about the neutron star crust and underlying dense matter. Comparisons between astronomical observations of these cooling transients and model calculations of neutron star crust cooling have frequently been used to constrain neutron star properties such as the mass, radius, crust composition, and presence of nuclear pasta. These calculations often use a fixed pressure at which the crust-core transition happens, though this quantity depends on the dense matter equation of state. We demonstrate that varying the crust-core transition pressure in a manner consistent with adopting various equations of state results in modest changes to the crust cooling light curve. This validates the approach adopted in most crust cooling studies to date, where the neutron star mass and radius are varied while leaving the crust-core transition pressure constant.
description: 6 figures
Additional file 1 of Evaluation of multi-level barriers and facilitators in a large diabetic retinopathy screening program in federally qualified health centers: a qualitative study
Creators: name: De Carvalho, Ana Bastos
name: S. Lee Ware
name: Belcher, Tamara
name: Franceska Mehmeti
name: Higgins, Eric B.
name: Sprang, Rob
name: Williams, Cody
name: Studts, Jamie L.
name: Studts, Christina R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Standards for Reporting Qualitative Research checklist.
Identification of potential inhibitors targeting yellow fever virus helicase through ligand and structure-based computational studies
Creators: name: Zaib, Sumera
name: Rana, Nehal
name: Ali, Hafiz Saqib
name: Rehman, Mujeeb ur
name: Awwad, Nasser S.
name: Ibrahium, Hala A.
name: Khan, Imtiaz
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Yellow fever is a flavivirus having plus-sensed RNA which encodes a single polyprotein. Host proteases cut this polyprotein into seven nonstructural proteins including a vital NS3 protein. The present study aims to identify the most effective inhibitor against the helicase (NS3) using different advanced ligand and structure-based computational studies. A set of 300 ligands was selected against helicase by chemical structural similarity model, which are similar to S-adenosyl-l-cysteine using infiniSee. This tool screens billions of compounds through a similarity search from in-built chemical spaces (CHEMriya, Galaxi, KnowledgeSpace and REALSpace). The pharmacophore was designed from ligands in the library that showed same features. According to the sequence of ligands, six compounds (29, 87, 99, 116, 148, and 208) were taken for pharmacophore designing against helicase protein. Subsequently, compounds from the library which showed the best pharmacophore shared-features were docked using FlexX functionality of SeeSAR and their optibrium properties were analyzed. Afterward, their ADME was improved by replacing the unfavorable fragments, which resulted in the generation of new compounds. The selected best compounds (301, 302, 303 and 304) were docked using SeeSAR and their pharmacokinetics and toxicological properties were evaluated using SwissADME. The optimal inhibitor for yellow fever helicase was 2-amino-N-(4-(dimethylamino)thiazol-2-yl)-4-methyloxazole-5-carboxamide (302), which exhibits promising potential for drug development.
On Schwarzschild causality in higher dimensions
Creators: name: Cameron, Peter
name: Dunajski, Maciej
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Paper
conformal infinity
causality
Schwarzschild solution

description: Abstract: We show that the causal properties of asymptotically flat spacetimes depend on their dimensionality: while the time-like future of any point in the past conformal infinity I− contains the whole of the future conformal infinity I+ in (2 + 1) and (3 + 1) dimensional Schwarzschild spacetimes, this property (which we call the Penrose property) does not hold for (d + 1) dimensional Schwarzschild if d > 3. We also show that the Penrose property holds for the Kerr solution in (3 + 1) dimensions, and discuss the connection with scattering theory in the presence of positive mass.
Simultaneous off-axis multiplexed holography and regular fluorescence microscopy of biological cells
Creators: name: Nygate, Yoav N.
name: Singh, Gyanendra
name: Barnea, Itay
name: Shaked, Natan T.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a new technique for obtaining simultaneous multimodal quantitative phase and fluorescence microscopy of biological cells, providing both quantitative phase imaging and molecular specificity using a single camera. Our system is based on an interferometric multiplexing module, externally positioned at the exit of an optical microscope. In contrast to previous approaches, the presented technique allows conventional fluorescence imaging, rather than interferometric off-axis fluorescence imaging. We demonstrate the presented technique for imaging fluorescent beads and live biological cells.
Setting the tree-ring record straight
Creators: name: Ludescher, Josef
name: Bunde, Armin
name: Büntgen, Ulf
name: Schellnhuber, Hans Joachim
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
Tree-ring
Temperature reconstructions
Harvest dates
Long-term persistence
Hurst exponent

description: Funder: Potsdam-Institut f├╝r Klimafolgenforschung (PIK) e.V. (3500)
description: Abstract: Tree-ring chronologies are the main source for annually resolved and absolutely dated temperature reconstructions of the last millennia and thus for studying the intriguing problem of climate impacts. Here we focus on central Europe and compare the tree-ring based temperature reconstruction with reconstructions from harvest dates, long meteorological measurements, and historical model data. We find that all data are long-term persistent, but in the tree-ring based reconstruction the strength of the persistence quantified by the Hurst exponent is remarkably larger (h≅1.02) than in the other data (h= 0.52–0.69), indicating an unrealistic exaggeration of the historical temperature variations.We show how to correct the tree-ring based reconstruction by a mathematical transformation that adjusts the persistence and leads to reduced amplitudes of the warm and cold periods. The new transformed record agrees well with both the observational data and the harvest dates-based reconstructions and allows more realistic studies of climate impacts. It confirms that the present warming is unprecedented.
On the theoretical uncertainties in the muon anomalous magnetic moment
Creators: name: Melnikov, Kirill
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I present a fairly detailed discussion of various contributions to the anomalous magnetic moment of the muon a_mu. I try to give an unbiased evaluation of the validity of the SM prediction for this quantity and to point out some delicate issues involved in its calculation. I conclude that the theory uncertainties in the SM prediction for the muon anomalous magnetic moment are underestimated and a great deal of work will be required to reduce these uncertainties to the level required by experiment.
description: 12 pages, revtex
Additional file 3 of Evaluation of multi-level barriers and facilitators in a large diabetic retinopathy screening program in federally qualified health centers: a qualitative study
Creators: name: De Carvalho, Ana Bastos
name: S. Lee Ware
name: Belcher, Tamara
name: Franceska Mehmeti
name: Higgins, Eric B.
name: Sprang, Rob
name: Williams, Cody
name: Studts, Jamie L.
name: Studts, Christina R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Complete interview structure.
Annonaceous acetogenins as promising DNA methylation inhibitors to prevent and treat leukemogenesis – an in silico approach
Creators: name: Subaramaniyam, Udayadharshini
name: Ramalingam, Divya
name: Balan, Ranjini
name: Paital, Biswaranjan
name: Sar, Pranati
name: Ramalingam, Nirmaladevi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Leukemia is a haematological malignancy affecting blood and bone marrow, ranking 10th among the other common cancers. DNA methylation is an epigenetic dysregulation that plays a critical role in leukemogenesis. DNA methyltransferases (DNMTs) such as DNMT1, DNMT3A and DNMT3B are the key enzymes catalysing DNA methylation. Inhibition of DNMT1 with secondary metabolites from medicinal plants helps reverse DNA methylation. The present study focuses on inhibiting DNMT1 protein (PDB ID: 3PTA) with annonaceous acetogenins through in-silico studies. The docking and molecular dynamic (MD) simulation study was carried out using Schrödinger Maestro and Desmond, respectively. These compounds’ drug likeliness, ADMET properties and bioactivity scores were analysed. About 76 different acetogenins were chosen for this study, among which 17 showed the highest binding energy in the range of −8.312 to −10.266 kcal/mol. The compounds with the highest negative binding energy were found to be annohexocin (-10.266 kcal/mol), isoannonacinone (-10.209 kcal/mol) and annonacin (-9.839 kcal/mol). MD simulation results reveal that annonacin remains stable throughout the simulation time of 100 ns and also binds to the catalytic domain of DNMT1 protein. From the above results, it can be concluded that annonacin has the potential to inhibit the DNA methylation process and prevent leukemogenesis.
Fakeons and microcausality: light cones, gravitational waves and the Hubble constant
Creators: name: Anselmi, Damiano
name: Marino, Antonio
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The concept of fake particle, or "fakeon", allows us to make sense of quantum gravity as an ultraviolet complete theory, by renouncing causality at very small distances. We investigate whether the violation of microcausality can be amplified or detected in the most common settings. We show that it is actually short range for all practical purposes. Due to our experimental limitations, the violation does not propagate along the light cones or by means of gravitational waves. In some cases, the universe even conspires to make the effect disappear. For example, the positivity of the Hubble constant appears to be responsible for the direction of time in the early universe.
description: 24 pages; CQG
Listroderes affinis Hustache 1926
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listroderes
Listroderes affinis

description: Listroderes affinis Hustache, 1926
 Listroderes affinis Hustache, 1926: 197 (type locality: Argentina: Río Negro; type material: H: MNHN and P: 1 MACN).
 Distribution. Southern Argentina and southern Chile (Morrone, 1993d).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 28, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Efficient Electrocatalytic Reduction of CO2 by Nitrogen-Doped Nanoporous Carbon-Carbon Nanotube Membranes - A Step Towards the Electrochemical CO2 Refinery
Creators: name: Wang, Hong
name: Jia, Jia
name: Song, Pengfei
name: Wang, Qiang
name: Li, Debao
name: Min, Shixiong
name: Qian, Chenxi
name: Wang, Lu
name: Li, Young Feng
name: Ma, Chun
name: Wu, Tom
name: Yuan, Jiayin
name: Antonietti, Markus
name: Ozin, Geoffrey A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The search for earth abundant, efficient and stable electrocatalysts that can enable the chemical reduction of CO2 to value-added chemicals and fuels at an industrially relevant scale, is a high priority for the development of a global network of renewable energy conversion and storage systems that can meaningfully impact greenhouse gas induced climate change. Here we introduce a straightforward, low cost, scalable and technologically relevant method to manufacture an all-carbon, electroactive, nitrogen-doped nanoporous carbon-carbon nanotube composite membrane, dubbed "HNCM-CNT". The membrane is demonstrated to function as a binder-free, high-performance electrode for the electrocatalytic reduction of CO2 to formate. The Faradaic efficiency for the production of formate is 81%. Furthermore, the robust structural and electrochemical properties of the membrane endow it with excellent long-term stability.
Visual Tree Convolutional Neural Network in Image Classification
Creators: name: Liu, Yuntao
name: Dou, Yong
name: Jin, Ruochun
name: Qiao, Peng
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In image classification, Convolutional Neural Network(CNN) models have achieved high performance with the rapid development in deep learning. However, some categories in the image datasets are more difficult to distinguished than others. Improving the classification accuracy on these confused categories is benefit to the overall performance. In this paper, we build a Confusion Visual Tree(CVT) based on the confused semantic level information to identify the confused categories. With the information provided by the CVT, we can lead the CNN training procedure to pay more attention on these confused categories. Therefore, we propose Visual Tree Convolutional Neural Networks(VT-CNN) based on the original deep CNN embedded with our CVT. We evaluate our VT-CNN model on the benchmark datasets CIFAR-10 and CIFAR-100. In our experiments, we build up 3 different VT-CNN models and they obtain improvement over their based CNN models by 1.36%, 0.89% and 0.64%, respectively.
description: 7 pages, 2 figures, conference
Review on methods of solving the refractive index-thickness coupling problem in digital holographic microscopy of biological cells
Creators: name: Dardikman, Gili
name: Shaked, Natan T.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Digital holographic microscopy is a thriving imaging modality that attracted considerable research interest in quantitative biological cell imaging due to its ability to not only create excellent label-free contrast, but also supply valuable physical information regarding the density and dimensions of the sample with nanometer-scale axial sensitivity. This technique records the interference pattern between a sample beam and a reference beam, and by digitally processing it, one can reconstruct the optical path delay between these beams. Per each spatial point, the optical path delay map is proportional to the product of the sample physical thickness and the integral refractive index of the sample. Since the refractive index of the cell indicates its contents without the need for labeling, it is highly beneficial to decouple cell physical thickness from its refractive index profile. This manuscript reviews various approaches of extracting the refractive index from digital holographic microscopy measurements of cells. As soon as the refractive index of the cell is available, it can be used for either biological assays or medical diagnosis, as reviewed in this manuscript.
Discovery potential for New Physics in view of the RHIC-Spin upgrade
Creators: name: Taxil, P.
name: Virey, J. -M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In view of a possible upgrade of the RHIC-Spin program at BNL, concerning both the machine and the detectors, we give some predictions concerning the potentialities of New Physics detection with polarized proton beams. We focus on parity-violating asymmetries in one-jet production due to contact terms or to a new leptophobic neutral gauge boson. We comment on the main uncertainties and we compare with unpolarized searches at Tevatron.
description: Latex file, 9 pages and 1 ps fig included with psfig.sty
Listroderes angusticeps Blanchard 1851
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listroderes
Listroderes angusticeps

description: Listroderes angusticeps Blanchard, 1851
 Listroderes angusticeps Blanchard, 1851: 341 (type locality: Chile: Mount Gray; type material: H: MNHN); Kuschel, 1946: 137 (subspecies of L. costirostris); Kuschel, 1955: 289 (reinstated as a distinct species).
 Listroderes proximus Germain, 1895: 76 (type locality: Chile; type material: H: MHNS); Kuschel, 1955: 289 (= L. angusticeps).
 Distribution. Central Chile (Morrone, 1993d).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 28, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Evaluating the Marketing Impact of a Regional Branding Program Using Contingent Valuation Methods: The Case of the Appalachian Grown™ Branding Program
Creators: name: Aborisade, Olumide
name: Carpio, Carlos E.
name: Mathews, Leah
name: Boonsaeng, Tullaya
name: Perrett, Allison
name: Descieux, Katie
name: Aborisade, Olumide
name: Carpio, Carlos E.
name: Mathews, Leah
name: Boonsaeng, Tullaya
name: Perrett, Allison
name: Descieux, Katie
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agribusiness
subject: Consumer/Household Economics
subject: Demand and Price Analysis
subject: Food Consumption/Nutrition/Food Safety
subject: Marketing
subject: FOS: Economics and business
subject: local food
subject: willingness to pay

description: The main objective of this study was to develop and test effective messaging and marketing efforts for the Appalachian Grown™ regional branding program. The study included the following activities: 1) A pilot consumer survey to design and evaluate messages and promotional materials to be used in the marketing campaign, 2) Pre and post intervention consumer surveys, and 3) Implementation of the marketing campaign in three stores in the region. The evaluation of the impact of the marketing efforts utilized contingent valuation methods. Our results indicate that consumers’ willingness to pay may be positively impacted by the implementation of in-store local food marketing campaigns. We also identified criteria of trustworthiness, including information about farm name and location, which local food marketing campaigns should consider implementing in the future.
Setting maximum levels for lead in game meat in EC regulations: An adjunct to replacement of lead ammunition
Creators: name: Thomas, Vernon G.
name: Pain, Deborah J.
name: Kanstrup, Niels
name: Green, Rhys E.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Perspective
Europe
Game meat
Hunting
International trade
Regulation
Scavengers

description: Abstract: Each year, hunters from 12 of the 27 European Union (EU) countries and the UK shoot over 6 million large game mammals, 12 million rabbits and hares and over 80 million birds. They support an international game meat market worth over 1.1 thousand million Euros. Animals shot with lead ammunition frequently contain lead fragments in the carcass which contaminate meals made from game meat with concentrations of lead substantially above the maximum allowable level (ML) set by European Commission Regulation EC1881/2006 for meat from domesticated animals. This poses a health risk to frequent consumers of wild-shot game meat, with children and pregnant women being particularly vulnerable. Total replacement of lead rifle and shotgun ammunition with available non-toxic alternatives is needed for all hunting in EU nations to prevent exposure of humans and wildlife to ammunition-derived lead and to allow the depletion of the long-term environmental legacy of lead from spent ammunition. We propose that EC1881/2006 is amended to incorporate an ML for game meats as a supplementary measure to the replacement of lead ammunition. This would harmonise food safety standards for lead in meats traded across and imported into the EU.
Additional file 5 of Comprehensive identification of somatic nucleotide variants in human brain tissue
Creators: name: Wang, Yifan
name: Bae, Taejeong
name: Thorpe, Jeremy
name: Sherman, Maxwell A.
name: Jones, Attila G.
name: Cho, Sean
name: Daily, Kenneth
name: Dou, Yanmei
name: Ganz, Javier
name: Galor, Alon
name: Lobon, Irene
name: Pattni, Reenal
name: Rosenbluh, Chaggai
name: Tomasi, Simone
name: Tomasini, Livia
name: Yang, Xiaoxu
name: Zhou, Bo
name: Akbarian, Schahram
name: Ball, Laurel L.
name: Bizzotto, Sara
name: Emery, Sarah B.
name: Doan, Ryan
name: Fasching, Liana
name: Jang, Yeongjun
name: Juan, David
name: Lizano, Esther
name: Luquette, Lovelace J.
name: Moldovan, John B.
name: Narurkar, Rujuta
name: Oetjens, Matthew T.
name: Rodin, Rachel E.
name: Sekar, Shobana
name: Shin, Joo Heon
name: Soriano, Eduardo
name: Straub, Richard E.
name: Zhou, Weichen
name: Chess, Andrew
name: Gleeson, Joseph G.
name: Marquès-Bonet, Tomas
name: Park, Peter J.
name: Peters, Mette A.
name: Pevsner, Jonathan
name: Walsh, Christopher A.
name: Weinberger, Daniel R.
name: Vaccarino, Flora M.
name: Moran, John V.
name: Urban, Alexander E.
name: Kidd, Jeffrey M.
name: Mills, Ryan E.
name: Abyzov, Alexej
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5. BSMN_Membership_List.
Additional file 4 of Evaluation of multi-level barriers and facilitators in a large diabetic retinopathy screening program in federally qualified health centers: a qualitative study
Creators: name: De Carvalho, Ana Bastos
name: S. Lee Ware
name: Belcher, Tamara
name: Franceska Mehmeti
name: Higgins, Eric B.
name: Sprang, Rob
name: Williams, Cody
name: Studts, Jamie L.
name: Studts, Christina R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 4. Manifestation of CFIR constructs.