cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ryanodine receptor and capacitative Ca2+ entry in fresh preglomerular vascular smooth muscle cells
Creators: name: Fellner, Susan
name: Arendshorst, William
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Ryanodine receptor and capacitative Ca2+ entry in fresh preglomerular vascular smooth muscle cells.A multiplicity of hormonal, neural, and paracrine factors regulates preglomerular arterial tone by stimulating calcium entry or mobilization. We have previously provided evidence for capacitative (store-operated) Ca2+ entry in fresh renal vascular smooth muscle cells (VSMCs). Ryanodine-sensitive receptors (RyRs) have recently been identified in a variety of nonrenal vascular beds.We isolated fresh rat preglomerular VSMCs with a magnetized microsphere/sieving technique; cytosolic Ca2+ ([Ca2+]i) was measured with fura-2 ratiometric fluorescence.Ryanodine (3 μmol/L) increased [Ca2+]i from 79 to 138 nmol/L (P = 0.01). Nifedipine (Nif), given before or after ryanodine, was without effect. The addition of calcium (1 mmol/L) to VSMCs in calcium-free buffer did not alter resting [Ca2+]i. In Ca-free buffer containing Nif, [Ca2+]i rose from 61 to 88 nmol/L after the addition of the Ca2+-ATPase inhibitor cyclopiazonic acid and to 159 nmol/L after the addition of Ca2+ (1 mmol/L). Mn2+ quenched the Ca/fura signal, confirming divalent cation entry. In Ca-free buffer with Nif, [Ca2+]i increased from 80 to 94 nmol/L with the addition of ryanodine and further to 166 nmol/L after the addition of Ca2+ (1 mmol/L). Mn2+ quenching was again shown. Thus, emptying of the sarcoplasmic reticulum (SR) with ryanodine stimulated capacitative Ca2+ entry.Preglomerular VSMCs have functional RyR, and a capacitative (store-operated) entry mechanism is activated by the depletion of SR Ca2+ with ryanodine, as is the case with inhibitors of SR Ca2+-ATPase.
Predicting the long-term citation impact of recent publications
Creators: name: Stegehuis, Clara
name: Litvak, Nelly
name: Waltman, Ludo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Digital Libraries (cs.DL)
subject: FOS: Computer and information sciences

description: A fundamental problem in citation analysis is the prediction of the long-term citation impact of recent publications. We propose a model to predict a probability distribution for the future number of citations of a publication. Two predictors are used: The impact factor of the journal in which a publication has appeared and the number of citations a publication has received one year after its appearance. The proposed model is based on quantile regression. We employ the model to predict the future number of citations of a large set of publications in the field of physics. Our analysis shows that both predictors (i.e., impact factor and early citations) contribute to the accurate prediction of long-term citation impact. We also analytically study the behavior of the quantile regression coefficients for high quantiles of the distribution of citations. This is done by linking the quantile regression approach to a quantile estimation technique from extreme value theory. Our work provides insight into the influence of the impact factor and early citations on the long-term citation impact of a publication, and it takes a step toward a methodology that can be used to assess research institutions based on their most recently published work.
description: 17 pages, 17 figures
Development of Low-cost Automated Zero Wastewater System to Step towards Industry 4.0
Creators: name: Parvez, Zaif
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 401102
subject: Environmentally sustainable engineering
classificationCode: 401105
subject: Life cycle assessment and industrial ecology
classificationCode: 401106
subject: Waste management, reduction, reuse and recycling

description: The following paper proposes the optimum uses of ETP-based water. It is known that ETP works as a waste purifier and treats the water obtained from industrial plants. This project aims to ensure proper reuse of the wastewater obtained from the ETP rather than throwing it into the environment directly. This project aims to work with the filtered water produced by ETP and put it to good use. The ETP wastewater is kept inside a reservoir and, later, passed through a unique and automated distribution system which leads to various end uses. This automated distribution system controls the wastewater supply to minimize resource waste. This project also includes using sludge obtained from the ETP plant by mixing it with concrete cement. Thus, the sludge will be reused to make storage components for a distribution system. The range of ETP wastewater uses can even be expanded with adequate execution based on the produced filtered water quality. Throughout ETP-based production, the field of operations can be distributed. Throughout ETP-based production, the field of operations can be distributed. And the overall goal of this project is "environmental sustainability" and complete wastewater management. If correctly implemented, this might be an ideal method for conserving vital water while safeguarding the environment. If correctly implemented, this might be an ideal method for conserving vital water while safeguarding the environment .
(100333) Agnes Jane Kyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
From the Fourth Color to Spin-charge Separation - Neutrinos and Spinons
Creators: name: Xiong, Chi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce the spin-charge separation mechanism to the quark-lepton unification models which consider the lepton number as the fourth color. In certain finite-density systems, quarks and leptons are decomposed into spinons and chargons, which carry the spin and charge degrees of freedom respectively. Neutrinos can be related to the spinons with respect to the electric-charge and spin separation in the early universe or other circumstances. Some effective, probably universal couplings between the spinon sector and the chargon sector are derived and a phenomenological description for the chargon condensate is proposed. It is then demonstrated that the spinon current can induce vorticity in the chargon condensate, and spinon zero modes are trapped in the vortices, forming spinon-vortex bound states. In cosmology this configuration may lead to the emission of extremely high energy neutrinos when vortices split and reconnect.
description: 8 pages, 1 figure. Talk given on Feb 10, 2015, International Conference on Massive Neutrinos, Singapore
Bi-quartic parametric polynomial minimal surfaces
Creators: name: Kassabov, Ognian
name: Vlachkova, Krassimira
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53A10, 65D17

description: Minimal surfaces with isothermal parameters admitting Bézier representation were studied by Cosin and Monterde. They showed that, up to an affine transformation, the Enneper surface is the only bi-cubic isothermal minimal surface. Here we study bi-quartic isothermal minimal surfaces and establish the general form of their generating functions in the Weierstrass representation formula. We apply an approach proposed by Ganchev to compute the normal curvature and show that, in contrast to the bi-cubic case, there is a variety of bi-quartic isothermal minimal surfaces. Based on the Bezier representation we establish some geometric properties of the bi-quartic harmonic surfaces. Numerical experiments are visualized and presented to illustrate and support our results.
description: 14 pages
(100328) Alexander Gibb Kyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(100329) John Kyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Trends in mortality rates on hemodialysis in Canada, 1981–1997
Creators: name: Fenton, Stanley
name: Schaubel, Douglas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Significant improvements in hemodialysis (HD) have occurred during recent years. Few previous studies have explicitly examined trends in patient outcomes over time. In order to evaluate whether improvements in HD have resulted in decreased mortality, we analyzed trends in mortality rates among the 28,700 patients who initiated HD in Canada during the 1981–1997 period. Mortality rate ratios (RR) were estimated using Poisson regression, and adjusted simultaneously for age, race, gender, primary renal diagnosis and follow-up time. Adjusted mortality rates decreased significantly by calendar period, with RR = 0.90 (95% CI: 0.83–0.96) for 1990–93 and RR = 0.74 (0.69–0.80) for 1994–97, relative to 1981–85 (reference; RR = 1). The decrease was concentrated in the first two years of follow-up. Among causes of death, mortality due to cardiovascular disease showed the sharpest decline. Among subgroups defined by age and diabetes status, mortality improvement was strongest among diabetics age <65 years and weakest among non-diabetics age <65 years. The observed decreases in HD mortality could be due to enhancements in dialysis technology, including improvements in dialysis machines, water purification systems, dialysate composition, and biocompatibility of dialyzer membranes. Key roles were likely played by increased attention to HD adequacy on the part of clinicians, improved nutrition, better management of comorbid conditions, and increased erythropoietin utilization. Detailed data on practice patterns are required in order that the degree of association between trends in dialysis methodology and mortality may be quantitatively evaluated.
title: Nuclear quests for the r-process
Creators: name: Martínez-Pinedo, Gabriel
name: Langanke, Karlheinz
Publisher: name: Springer
Year: 2025

description: The astrophysical r-process produces about half of the elements heavier than iron in the Universe and all of the transactinides. Recently neutron star mergers have been identified as one site of r-process nucleosynthesis. Simulations of this site and the associated nucleosynthesis requires essential nuclear input, ranging from the Equation of State (EoS) of nuclear matter at extreme densities and temperatures to the properties of very neutron-rich nuclei. Many of these quantities have to be modeled, however, constrained by a steadily increasing amount of experimental data. This manuscript summarizes the knowledge of nuclear input required for r-process studies in neutron star mergers.
Endothelin A and B receptors of preglomerular vascular smooth muscle cells
Creators: name: Fellner, Susan K.
name: Arendshorst, William J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: BACKGROUND: The endothelin (ET) receptors are subclassified into ET(A,) which are purely vasoconstrictive, and ET(B). The ET(B) receptors may cause either vasodilation by stimulating the release of nitric oxide from endothelial cells, or vasoconstriction of vascular smooth muscle cells (VSMC). The relative contribution of ET(A) and ET(B) receptors to calcium signaling and vasoconstriction in the renal microcirculation is not clear. Our goal was to study the cytosolic calcium concentration ([Ca(2+)](i)) responses of fresh rat preglomerular VSMC and afferent arterioles to agonists and antagonists of ET(A) and ET(B) receptors in rats. METHODS: Fresh VSMC and afferent arterioles were isolated using the magnetized microsphere/sieving technique, followed by gentle collagenase digestion. [Ca(2+)](i) was measured with fura-2 ratiometric fluorescence. RESULTS: Afferent arterioles and VSMC responded to ET-1 stimulation with a rapid peak increase in [Ca(2+)](i) (Delta= 287 +/- 81 and 342 +/- 55 nmol/L, respectively). The ET(B) receptor agonist IRL 1620 stimulated a rise in [Ca(2+)](i) in afferent arterioles (106 +/- 35 nmol/L); subsequent addition of ET-1 at the IRL 1620 nadir to stimulate ET(A) receptors caused a second peak that was twice as large (213 +/- 44 nmol/L). In VSMC, the ET(B) agonist peak increase was 99 +/- 12 nmol/L; addition of ET-1 then increased [Ca(2+)](i) by 294 +/- 23 nmol/L. The ET(B) inhibitor BQ-788 prevented stimulation of [Ca(2+)](i) by IRL 1620 in afferent arterioles and VSMC; subsequent stimulation of ET(A) receptors with ET-1 caused an increase in [Ca(2+)](i) (239 +/- 17 and 248 +/- 22 nmol/L). Pretreatment with the selective ET(A) inhibitor PD 156707 attenuated but did not abolish the responses to ET-1, suggesting that the residual [Ca(2+)](i) response was caused by ET(B) stimulation. CONCLUSION: These results indicate that fresh preglomerular VSMC as well as afferent arterioles have both ET(A) and ET(B) receptors, and that the rapid peak [Ca(2+)](i) responses to the ET(B) agonist IRL 1620 are less than half that of subsequent stimulation of ET(A) receptors with ET-1. The similarity of findings in isolated VSMC and afferent arterioles suggests that responses in VSMC in our arteriolar preparation overshadow any potential contribution of endothelial cells when reagents are administered abluminally.
Effect of surgery versus chemotherapy in pancreatic cancer patients: a target trial emulation
Creators: name: Heide-Jørgensen, Uffe
name: Gaber, Charles
name: Mortensen, Frank Viborg
name: Cronin-Fenton, Deirdre
name: Fristrup, Claus Wilki
name: Kirkegård, Jakob
name: Lund, Jennifer L
Publisher: name: Oxford University Press (OUP)
Year: 2024

description: BACKGROUND: To estimate the causal effect of surgery vs chemotherapy on survival in patients with T1-3NxM0 pancreatic cancer in a rigorous framework addressing selection bias and immortal time bias.
METHODS: We used population-based Danish health-care registries to conduct a cohort study emulating a hypothetical randomized trial to estimate the absolute difference in survival, comparing surgery with chemotherapy. We included pancreatic cancer patients diagnosed during 2008-2021. Exposure was surgery or chemotherapy initiated within a 16-week grace period after diagnosis. At the time of diagnosis, data of each patient were duplicated; one copy was assigned to the surgery protocol, and one copy to the chemotherapy protocol of the hypothetical trial. Copies were censored when the assigned treatment deviated from the observed treatment. To account for informative censoring, uncensored patients were weighted according to confounders. For comparison, we also applied a more conventional analysis using propensity score-based inverse probability weighting.
RESULTS: We included 1744 patients with a median age of 68 years: 73.6% underwent surgery, and 18.6% had chemotherapy without surgery; 7.8% received no treatment. The 3-year survival was 39.7% (95% confidence interval [CI] = 36.7% to 42.6%) after surgery and 22.7% (95% CI = 17.7% to 28.4%) after chemotherapy, corresponding to an absolute difference of 17.0% (95% CI = 10.8% to 23.1%). In the conventional survival analysis, this difference was 23.0% (95% CI = 17.0% to 29.0%).
CONCLUSION: Surgery was superior to chemotherapy in achieving long-term survival for pancreatic cancer. The difference comparing surgery and chemotherapy was substantially smaller when using the clone-censor-weight approach than conventional survival analysis.
(100330) Margaret Kyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Effective collision strengths between Mg I and electrons
Creators: name: Merle, T.
name: Thévenin, F.
name: Zatsarinny, O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The treatment of the inelastic collisions with electrons and hydrogen atoms are the main source of uncertainties in non-Local Thermodynamic Equilibrium (LTE) spectral line computations. We report, in this research note, quantum mechanical data for 369 collisional transitions of \ion{Mg}{I} with electrons for temperatures comprised between 500 and 20000~K. We give the quantum mechanical data in terms of effective collision strengths, more practical for non-LTE studies.
description: 9 pages, 1 figure, 2 tables, research note accepted by A&A
title: A new model to describe small-angle neutron scattering from foams
Creators: name: Kühnhammer, Matthias
name: Braun, Larissa
name: Ludwig, Michael
name: Soltwedel, Olaf
name: Chiappisi, Leonardo
name: Klitzing, Regine von
Publisher: name: International Union of Crystallography
Year: 2024

description: The modelling of scattering data from foams is very challenging due to the complex structure of foams and is therefore often reduced to the fitting of single peak positions or feature mimicking. This article presents a more elaborate model to describe the small-angle neutron scattering (SANS) data from foams. The model takes into account the geometry of the foam bubbles and is based on an incoherent superposition of the reflectivity curves arising from the foam films and the small-angle scattering (SAS) contribution from the plateau borders. The model is capable of describing the complete scattering curve of a foam stabilized by the standard cationic surfactant tetradecyltrimethylammonium bromide (C14TAB) with different water contents, i.e. different drainage states, and provides information on the thickness distribution of liquid films inside the foam. The mean film thickness decreases with decreasing water content because of drainage, from 28 to 22 nm, while the polydispersity increases. These results are in good agreement with the film thicknesses of individual horizontal foam films studied with a thin-film pressure balance.
Fixed Point Realization of Iterative LR-Aided Soft MIMO Decoding Algorithm
Creators: name: Rahman, Mehnaz
name: Choi, Gwan S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Multiple-input multiple-output (MIMO) systems have been widely acclaimed in order to provide high data rates. Recently Lattice Reduction (LR) aided detectors have been proposed to achieve near Maximum Likelihood (ML) performance with low complexity. In this paper, we develop the fixed point design of an iterative soft decision based LR-aided K-best decoder, which reduces the complexity of existing sphere decoder. A simulation based word-length optimization is presented for physical implementation of the K-best decoder. Simulations show that the fixed point result of 16 bit precision can keep bit error rate (BER) degradation within 0.3 dB for 8x8 MIMO systems with different modulation schemes.
description: submitted to SPIJ (Signal Processing: An International Journal),(under review), 10 pages, 5 figures
Polarizabilities of the 87Sr Clock Transition
Creators: name: Shi, C
name: Robyr, J. -L
name: Eismann, U
name: Zawada, M
name: Lorini, L
name: Targat, R Le
name: Lodewyck, J
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: In this paper, we propose an in-depth review of the vector and tensor polarizabilities of the two energy levels of the 87Sr clock transition whose measurement was reported in [P. G. Westergaard et al., Phys. Rev. Lett. 106, 210801 (2011)]. We conduct a theoretical calculation that reproduces the measured coefficients. In addition, we detail the experimental conditions used for their measurement in two Sr optical lattice clocks, and exhibit the quadratic behaviour of the vector and tensor shifts with the depth of the trapping potential and evaluate their impact on the accuracy of the clock.
Improving Collaborations in Neuroscientist Community
Creators: name: Mirbel, Isabelle
name: Crescenzo, Pierre
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: In this paper, we present our approach, called SATIS (Semantically AnnotaTed Intentions for Services), relying on intentional process modeling and semantic web technologies and models, to assist collaboration among the members of a neurosciences community. The main expected result of this work is to derive and share semantic web service specifications from a neuro-scientists point of view in order to operationalise image analysis pipelines with web services.
description: {\'e}galement rapport de recherche I3S/RR--2009-05--FR
Globally Optimized TDOA High Frequency Source Localization Based on Quasi-Parabolic Ionosphere Modeling and Collaborative Gradient Projection
Creators: name: Xiong, Wenxin
name: Schindelhauer, Christian
name: So, Hing Cheung
Publisher: name: arXiv
Year: 2023
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We investigate the problem of high frequency (HF) source localization using the time-difference-of-arrival (TDOA) observations of ionosphere-refracted radio rays based on quasi-parabolic (QP) modeling. An unresolved but pertinent issue in such a field is that the existing gradient-type scheme can easily get trapped in local optima for practical use. This will lead to the difficulty in initializing the algorithm and finally degraded positioning performance if the starting point is inappropriately selected. In this paper, we develop a collaborative gradient projection (GP) algorithm in order to globally solve the highly nonconvex QP-based TDOA HF localization problem. The metaheuristic of particle swarm optimization (PSO) is exploited for information sharing among multiple GP models, each of which is guaranteed to work out a critical point solution to the simplified maximum likelihood formulation. Random mutations are incorporated to avoid the early convergence of PSO. Rather than treating the geolocation of HF transmitter as a pure optimization problem, we further provide workarounds for addressing the possible impairments and challenges when the proposed technique is applied in practice. Numerical results demonstrate the effectiveness of our PSO-assisted re-initialization strategy in achieving the global optimality, and the superiority of our method over its competitor in terms of positioning accuracy.
description: This is the accepted version. The final version of this paper has been published in the IEEE Transactions on Aerospace and Electronic Systems. The copyright is with IEEE. This version prevails, as there are unfortunately uncorrected editing mistakes in the final one
title: Cultures of sustainability governance in higher education institutions
title: A multi‐case study of dimensions and implications
titleType: Subtitle
Creators: name: Niedlich, Sebastian
name: Kummer, Benjamin
name: Bauer, Mara
name: Rieckmann, Marco
name: Bormann, Inka
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: sustainability governance
subject: multi-case study
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung

description: Organisational culture is frequently mentioned in the context of sustainability governance in higher education institutions, but its substance and role for organisational development remain largely unclear. This paper argues that, in fact, sustainability governance in higher education institutions is predicated on cultural orientations. These are explored empirically based on 61 expert interviews with stakeholders (management, sustainability commissioners, academic and technical staff, students) in eleven German higher education institutions. Qualitative (thematic, evaluative) content analysis was used to code and compare data across cases. The study identifies four cultural key dimensions and two overarching orientations: organisational learning orientation and holistic orientation. The analysis suggests that both orientations tend to reinforce each other. They also represent key areas which need to be addressed by higher education institutions seeking change towards sustainable development. The findings demonstrate the need for future research on organisational cultures of sustainability governance and their development over time.
Gene expression profiles of circulating leukocytes correlate with renal disease activity in IgA nephropathy
Creators: name: Jennette, J. Charles
name: Sasai, Hitoshi
name: Phillips, Brian
name: Alcorta, David A.
name: Munger, William E.
name: Sullivan, Pamela
name: Preston, Gloria A.
name: Falk, Ronald J.
name: Waga, Iwao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: BACKGROUND: The goal of these studies was to explore the possibility of using gene expression profiles of circulating leukocytes as a functional fingerprint of nephritic disease activity. METHODS: This feasibility study utilized IgA nephropathy (IgAN) as a model system. Genes differentially expressed in IgAN patients were identified by Affymetrix GeneChip microarrays, and compared with gene expression of focal segmental glomerulosclerosis (FSGS), minimal change disease, antineutrophil cytoplasmic antibody (ANCA) glomerulonephritis, and with healthy volunteers. Of the genes identified, 15 transcriptionally up-regulated were validated in a larger cohort of patients using TaqMan polymerase chain reaction (PCR). To test whether increased expression of these genes correlated with disease activity, cluster analyses were performed utilizing the TaqMan PCR values. Taking a mathematical approach, we tested whether gene expression values were correlative with kidney function, as reflected by serum creatinine and creatinine clearance values. RESULTS: We identified 15 genes significantly correlative with disease activity in IgAN. This gene signature of IgAN patients' leukocytes reflected kidney function. This was demonstrated in that mathematically generated theoretical values of serum creatinine and creatinine clearance correlated significantly with actual IgAN patient values of serum creatinine and creatinine clearance. There was no apparent correlation with hematuria and proteinuria. The expression levels of this same gene set in ANCA glomerulonephritis or Lupus nephritis patients were not correlative with serum creatinine or creatinine clearance values. CONCLUSION: These data indicate that leukocytes carry informative disease-specific markers of pathogenic changes in renal tissue.
Survival of liver transplant candidates with acute renal failure receiving renal replacement therapy
Creators: name: Klemmer, Philip
name: Andreoni, Kenneth
name: Blackley, Molly
name: Wong, Leslie
name: Falk, Ronald
name: Chin, Hyunsook
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Acute renal failure (ARF) in the setting of end-stage liver disease has a dismal prognosis without liver transplantation. Renal replacement therapy (RRT) is a common bridge to liver transplant...
Maximizing Energy Efficiency in Multiple Access Channels by Exploiting Packet Dropping and Transmitter Buffering
Creators: name: Butt, M. Majid
name: Jorswieck, Eduard A.
name: Ottersten, Bjorn
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Quality of service (QoS) for a network is characterized in terms of various parameters specifying packet delay and loss tolerance requirements for the application. The unpredictable nature of the wireless channel demands for application of certain mechanisms to meet the QoS requirements. Traditionally, medium access control (MAC) and network layers perform these tasks. However, these mechanisms do not take (fading) channel conditions into account. In this paper, we investigate the problem using cross layer techniques where information flow and joint optimization of higher and physical layer is permitted. We propose a scheduling scheme to optimize the energy consumption of a multiuser multi-access system such that QoS constraints in terms of packet loss are fulfilled while the system is able to maximize the advantages emerging from multiuser diversity. Specifically, this work focuses on modeling and analyzing the effects of packet buffering capabilities of the transmitter on the system energy for a packet loss tolerant application. We discuss low complexity schemes which show comparable performance to the proposed scheme. The numerical evaluation reveals useful insights about the coupling effects of different QoS parameters on the system energy consumption and validates our analytical results.
description: in IEEE trans. Wireless communications, 2015
PSIXOLOGIK VA PEDAGOGIK TADQIQOTLAR ASOSIDA TAʼLIMDA YANGI TEXNOLOGIYALARNI QOʻLLASHNING SAMARADORLIGI
Creators: name: Hayitmurodova, Gulinur
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqola zamonaviy ta'lim tizimida yangi texnologiyalarni qo'llashning dolzarbligi va ahamiyati, shuningdek, psixologik va pedagogik tadqiqiotlarning ta'limda yangi texnologiyalarni foydalanishga ta'siri haqida ma'lumot beradi. Bundan tashqari, oʻquvchilarning texnologiyalarni qoʻllashga bo`lgan munosabati va ularning ta'lim samaradorligiga ta'siri, turli oʻquv fanlarida texnologiyalardan foydalanishning oʻziga xos xususiyatlari, oʻqituvchilarning texnologiyalarni qoʻllashga tayyorligi  va ularning malakasini oshirish kabi jihatlar tahlil etiladi.
title: An improved particle method for simulations of slamming with fluid-structure interaction
Creators: name: Zha, Ruosi
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: It is important to study the wave impact and slamming problems, involving breaking free surface, which can cause high impact pressure and therefore structural damage on ship hulls and offshore platforms. An improved higher-order moving particle semi-implicit (MPS) method was developed to solve 2-D water entry problems. To overcome the inconsistency in the original MPS methods, a pressure gradient model was modified to guarantee the first-order consistency and to satisfy the conservation of momentum simultaneously. A particle shifting technique was also applied to improve the numerical stability. Validation studies were carried out for water entry of a rigid wedge with a deadrise angle of 30ﾟ and the tilt angles of 0ﾟ, 10ﾟ and 20ﾟ and two rigid ship sections. Convergence studies were conducted on domain size, particle spacing and time step. A Particle Convergence Index (PCI) method was proposed to evaluate numerical uncertainties in solutions by the Lagrangian particle-based methods. Uncertainties of the numerical solutions due to spatial discretization were calculated. The predicted impact pressures and forces by the present method are in good agreement with experimental data and other published numerical results. The improved higher-order MPS method has also been applied to study fluidstructure interactions (FSI) for an elastic wedge entering calm water. The structural responses of the wedge with a reinforce tip were computed during the water entry. In the present method, different particle spacings and time steps were used for the fluid and the structure. Convergence of solutions on the particle spacings for the fluid and the structure and time step were investigated. Uncertainties of the numerical solutions due to spatial discretization of both the fluid and the structure were evaluated based on the proposed PCI method. Validation studies were carried out to two wedges with deadrise angles of 20ﾟ and 30ﾟ entering water at various velocities. Numerical solutions were compared with the results based on the original higher-order MPS model and the experimental data. The present improved higher-order MPS method led to better agreement with experimental data than the original one, and significantly reduced the oscillations in numerical solutions.
Synthesis and Characterization of Poly(hydrogen halide) Halogenates (–I)
Creators: name: Voßnacker, Patrick
name: Steinhauer, Simon
name: Bader, Julia
name: Riedel, Sebastian
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Poly(hydrogen halide)Halogenates (–I)
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::546 Anorganische Chemie

description: Herein, we report the synthesis and characterization of a variety of novel poly(hydrogen halide) halogenates (−I). The bifluoride ion, which is known to have the highest hydrogen bond energy of ≈160 kJ mol−1, is the most famous among many examples of [X(HX)n]− anions (X=F, Cl) known in the literature. In contrast, little is known about poly(hydrogen halide) halogenates containing two different halogens, ([X(HY)n]−). In this work we present the synthesis of anions of the type [X(HY)n]− (X=Br, I, ClO4; Y=Cl, Br, CN) stabilized by the [PPh4]+ and [PPN]+ cation. The obtained compounds have been characterized by single‐crystal X‐ray diffraction, Raman spectroscopy and quantum‐chemical calculations. In addition, the behavior of halide ions in hydrogen fluoride was investigated by using experimental and quantum‐chemical methods in order to gain knowledge on the acidity of hydrogen halides in HF.
Simply generated non-crossing partitions
Creators: name: Kortchemski, Igor
name: Marzouk, Cyril
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We introduce and study the model of simply generated non-crossing partitions, which are, roughly speaking, chosen at random according to a sequence of weights. This framework encompasses the particular case of uniform non-crossing partitions with constraints on their block sizes. Our main tool is a bijection between non-crossing partitions and plane trees, which maps such simply generated non-crossing partitions into simply generated trees so that blocks of size $k$ are in correspondence with vertices of outdegree $k$. This allows us to obtain limit theorems concerning the block structure of simply generated non-crossing partitions. We apply our results in free probability by giving a simple formula relating the maximum of the support of a compactly supported probability measure on the real line in term of its free cumulants.
description: 31 pages, 11 figures
Mapping of myeloperoxidase epitopes recognized by MPO-ANCA using human-mouse MPO chimers
Creators: name: Erdbrügger, U.
name: Falk, R.J.
name: Bunch, D.O.
name: Hellmark, T.
name: Jennette, J.C.
name: Nachman, P.H.
name: Alcorta, D.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Myeloperoxidase (MPO) is one of the major target antigens of antineutrophil cytoplasmic autoantibodies (ANCA) found in patients with small-vessel vasculitis and pauci-immune necrotizing glomerulonephritis. To date, the target epitopes of MPO-ANCA remain poorly defined. Human MPO-ANCA do not typically bind mouse MPO. We utilized the differences between human and mouse MPO to identify the target regions of MPO-ANCA. We generated five chimeric MPO molecules in which we replaced different segments of the human or mouse molecules with their homologous counterpart from the other species. Of serum samples from 28 patients screened for this study, 43 samples from 14 patients with MPO-ANCA-associated vasculitis were tested against recombinant human and mouse MPO and the panel of chimeric molecules. Sera from 64 and 71% of patients bound to the carboxy-terminus of the heavy chain, in the regions of amino acids 517-667 or 668-745, respectively. No patient serum bound the MPO light chain or the amino-terminus of the heavy chain. All sera bound to only one or two regions of MPO. Although the pattern of MPO-ANCA binding changed over time (4-27 months) in 6 of 10 patients with several serum samples, such changes were infrequent. Other target regions of MPO-ANCA may not have been detected due to conformational differences between the native and recombinant forms of MPO. MPO-ANCA do not target a single epitope, but rather a small number of regions of MPO, primarily in the carboxy-terminus of the heavy chain.
Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: No adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy
Creators: name: Barnett, M.E.
name: Altmann, P.
name: Finn, W.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Patients with Stage 5 chronic kidney disease who have hyperphosphatemia require treatment with phosphate binders to lower serum phosphorus levels. Existing binders are effective but may be associated with important safety disadvantages. Lanthanum carbonate is a phosphate binder with demonstrated efficacy, safety, and tolerability in clinical trials. Changes in cognitive function were evaluated over time using the Cognitive Drug Research computerized cognitive assessment system (Simple Reaction Time, Digit Vigilance Task, Choice Reaction Time, Numeric Working Memory, and Delayed Picture Recognition) in 360 hemodialysis patients who were enrolled in a 2-year, multicenter, comparative study of lanthanum carbonate versus standard therapy. A decline in cognitive function from baseline was observed in both groups. The deterioration in cognitive function was similar in both the lanthanum carbonate and standard therapy groups. One parameter - Numeric Working Memory - showed a statistically significant between-group difference in favor of lanthanum carbonate (P=0.02). Given the magnitude of the changes, however, and the differences that were observed at baseline between treatment groups, the clinical significance of this difference is doubtful. This study demonstrates that cognitive function deteriorates in hemodialysis patients over a 2-year time period. Use of lanthanum carbonate as a phosphate binder does not adversely affect cognitive function compared with standard therapy.
(100331) Thomas Kyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nanocrystalline CaWO$_4$ and ZnWO$_4$ Tungstates for Hybrid Organic-Inorganic X-ray Detectors
Creators: name: Pudza, Inga
name: Pudzs, Kaspars
name: Tokmakovs, Andrejs
name: Strautnieks, Normunds Ralfs
name: Kalinko, Aleksandr
name: Kuzmin, Alexei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Hybrid materials combining an organic matrix and high-Z nanomaterials show potential for applications in radiation detection, allowing unprecedented device architectures and functionality. Herein, novel hybrid organic-inorganic systems were produced using a mixture of tungstate (CaWO$_4$ or ZnWO$_4$) nanoparticles with a P3HT:PCBM blend. The nano-tungstates with a crystallite size of 43 nm for CaWO$_4$ and 30 nm for ZnWO$_4$ were synthesized by the hydrothermal method. Their structure and morphology were characterized by X-ray diffraction and scanning electron microscopy. The hybrid systems were used to fabricate direct conversion X-ray detectors able to operate with zero bias voltage. The detector performance was tested in a wide energy range using monochromatic synchrotron radiation. The addition of nanoparticles with high-Z elements improved the detector response to X-ray radiation compared with that of a pure organic P3HT:PCBM bulk heterojunction cell. The high dynamic range of our detector allows for recording X-ray absorption spectra, including the fine X-ray absorption structure located beyond the absorption edge. The obtained results suggest that nanocrystalline tungstates are promising candidates for application in direct organic-inorganic X-ray detectors.
Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate
Creators: name: Li, F.
name: Li, Y.
name: Swenberg, J.A.
name: Takahashi, N.
name: Boysen, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Endogenous creatinine clearance (Ccr) is widely accepted as an estimate of glomerular filtration rate (GFR), the best overall biomarker of kidney function. However, current common methods of measuring creatinine are not sensitive enough for mouse plasma. Accordingly, we here report a new method of measuring creatinine by liquid chromatography tandem mass spectrometry (LC-MS/MS) using deuterated [2H3]-creatinine as an internal standard. The assay requires 10 microl or less of plasma or urine, and is eight times more sensitive than high-performance liquid chromatography. The reproducibility of the assay of replicates is approximately +/-10%. The plasma creatinine levels of wild type male C57BL/6J mice obtained by LC-MS/MS are 0.076+/-0.002 mg/dl (n=65). To estimate daily urinary creatinine excretion for calculating Ccr, we collected urine from mice housed in metabolic cages, and combined this with washes from the cage internal surfaces. Creatinine in the wash varies from 4 to 67% of the total daily urinary creatinine excretion (typically approximately 400 microg/day). Ccr obtained by LC-MS/MS was 329+/-17 microl/min, which is indistinguishable from GFR measured by using fluorescein isothiocyanate-inulin. The LC-MS/MS method is sensitive, specific, simple, fast, and inexpensive; it is suitable for estimating GFR in conscious mice or other small animals. As it allows repeated measurements in the same animals, it facilitates detection of subtle differences or changes in renal function.
(100326) Margaret Kyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Why are you thriving when I'm barely surviving?: An exploration of personal resiliency factors that enable novice nurses to thrive
Creators: name: Dames, Shannon
Publisher: name: Werklund School of Education, University of Calgary
Year: 2020
Subjects: subject: Nurses--Job stress
subject: Burn out (Psychology)
subject: Nursing--Practice
subject: Nursing--Psychological aspects

description: Despite exposure to similar workplace stressors, some novice nurses manage to thrive while others experience high levels of emotional exhaustion and burnout. This qualitative research study of eight novice nurses from British Columbia, Canada explored the interplay of personal resiliency factors that enable nurses to thrive in their nursing roles. The study outcomes demonstrate that personal resiliency factors play a significant role in how the novice nurse participants interpreted workplace stimuli, either as challenges they felt confident to navigate, or as threatening stressors. The most prominent personal resiliency factors that impacted the novice nurses’ ability to thrive included congruence, self-compassion, self-efficacy, and the resulting ability to navigate workplace stressors. Personal resiliency impacts the ability to navigate the stressors endemic in many novice nurse work environments. Study results underscore the importance of resilience education for nurses in training and ongoing support as they cross the threshold into professional practice.