title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ¸ÑÑÐµÐ¼Ñ Ð³Ð¸Ð±ÐºÐ¸Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð² Ð´Ð»Ñ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿ÑÐ¸ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ°Ð²Ð¼Ñ ÑÐ¿Ð¸Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of a system of flexible electrodes for neurophysiological studies in the modeling of chronic spinal cord injury
Creators: name: Ð¡Ð°ÑÐ°ÑÐ¾Ð², ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÑÐ°Ð²Ð¼Ð° ÑÐ¿Ð¸Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°
ÑÐ»ÐµÐºÑÑÐ¾Ð´Ñ
Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ
ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð²
Ð¼Ð°Ð½Ð¶ÐµÑÐ½ÑÐµ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ñ
Ð¸Ð³Ð¾Ð»ÑÑÐ°ÑÑÐµ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ñ
Ð½Ð¸ÑÑÐ°ÑÑÐµ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ñ
spinal cord injury
electrodes
neurophysiological studies
electrode system
cuff electrodes
needle electrodes
filamentous electrodes

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð³Ð¸Ð±ÐºÐ¸Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð² Ð´Ð»Ñ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿ÑÐ¸ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ ÑÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ°Ð²Ð¼Ñ ÑÐ¿Ð¸Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°. Ð ÑÐ¾Ð´Ðµ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¿Ð¾ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐ¸ÑÑÐµÐ¼ Ð¸Ð½Ð²Ð°Ð·Ð¸Ð²Ð½ÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð² Ð´Ð»Ñ Ð´Ð»Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹, ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ¸ÑÑÐµÐ¼Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð² Ð´Ð»Ñ ÑÐµÐ»ÐµÐ²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÑÐ°Ð²Ð¼Ñ ÑÐ¿Ð¸Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð½Ð° ÐºÑÐ¾Ð»Ð¸ÐºÐµ, ÑÐ¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð° Ð¸ ÑÐ¾Ð±ÑÐ°Ð½Ð° ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ° Ð´Ð»Ñ Ð½Ð°Ð½ÐµÑÐµÐ½Ð¸Ñ ÑÐ¸Ð»Ð¸ÐºÐ¾Ð½Ð¾Ð²Ð¾Ð¹ Ð¸Ð·Ð¾Ð»ÑÑÐ¸Ð¸ Ð½Ð° Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÑ Ð¿ÑÐ¾Ð²Ð¾Ð»Ð¾ÐºÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð¾Ð±ÑÐ°Ð·ÑÑ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¾Ð² Ð±ÑÐ»Ð¸ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ, Ð´Ð»Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð³Ð¾ Ð¾ÑÐ²ÐµÑÐ° Ð½Ð° Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ. Ð ÑÐµÑÐµÐ½Ð¸Ðµ 8 Ð½ÐµÐ´ÐµÐ»Ñ Ð¸Ð·Ð¾Ð»Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð°, Ð½Ðµ Ð¾ÐºÐ°Ð·ÑÐ²Ð°Ð»Ð¸ ÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð° Ð¾ÐºÑÑÐ¶Ð°ÑÑÐ¸Ðµ ÑÐºÐ°Ð½Ð¸ Ð¸ Ð¿Ð¾ÐºÑÑÐ»Ð¸ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÐºÐ°Ð½Ð½Ð¾Ð¹ ÐºÐ°Ð¿ÑÑÐ»Ð¾Ð¹. Ð¢Ð°ÐºÐ¶Ðµ Ð±ÑÐ»Ð° ÑÐ¾Ð±ÑÐ°Ð½Ð° ÑÐ¸Ð½Ð°Ð»ÑÐ½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð², ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð±ÑÐ»Ð° Ð°Ð¿ÑÐ¾Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð° in vivo Ð½Ð° Ð´Ð²ÑÑ ÐºÑÐ¾Ð»Ð¸ÐºÐ°Ñ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð°Ð¼Ð¿Ð»Ð¸ÑÑÐ´Ñ ÑÐ¸Ð³Ð½Ð°Ð»Ð°, Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ Ð¿ÑÐµÐ´ÑÐ´ÑÑÐµÐ¹ ÑÐ¸ÑÑÐµÐ¼Ð¾Ð¹, Ð¸ ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸Ðµ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° Ð°ÑÑÐµÑÐ°ÐºÑÐ¾Ð² Ð¿ÑÐ¸ Ð·Ð°Ð¿Ð¸ÑÐ¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð² Ð¼Ð¾Ð¶ÐµÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÑÑÑÑ Ð² Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ½ÑÑ ÑÐµÐ»ÑÑ, Ð¿ÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ ÑÑÐ°Ð²Ð¼Ñ ÑÐ¿Ð¸Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð½Ð° Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ.
description: This work is devoted to the development of a system of flexible electrodes for neurophysiological studies in the simulation of chronic spinal cord injury. In the course of the work, an analysis of the literature data on the development of invasive electrode systems for long-term neurophysiological studies was carried out, the concept of an implantable electrode system for the target model of spinal cord injury on a rabbit was developed, and an installation for applying silicone insulation to the wire surface was designed and assembled. The resulting wire samples were implanted in rats to study the tissue response to the materials. According to the results of histological examinations, the wires covered with insulation did not have a toxic effect on the surrounding tissues and, within 8 weeks, were covered with a connective tissue capsule. The final electrode system was also assembled, which was tested in vivo on two rabbits. The results of neurophysiological studies showed an increase in the amplitude of the signal, compared with the previous system, and a decrease in the number of artifacts during recording. The developed system of electrodes can be used for laboratory purposes, in the study of neurophysiological indicators of spinal cord injury in laboratory animals.