cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Movie S1. High-speed video of snap-jaw strike loading phase. from Snap-jaw morphology is specialized for high-speed power amplification in the Dracula ant, Mystrium camillae
Creators: name: Larabee, Fredrick J.
name: Smith, Adrian A.
name: Suarez, Andrew V.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 60801 Animal Behaviour

description: Representative video used for visualization of the loading phase and for FEA validation. Filmed at 1000 frames s-1.
Regulation and Autoregulation of the Promoter for the Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus
Creators: name: Kim, Jong Wook
name: McMurtrey, Curtis P.
name: Dittmer, Dirk P.
name: Jeong, Joseph H.
name: Renne, Rolf
name: Orvis, Joshua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 has been established as the etiological agent of Kaposi's sarcoma and certain AIDS-associated lymphomas. KSHV establishes latent infection in these tumors, invariably expressing high levels of the viral latency-associated nuclear antigen (LANA) protein. LANA is necessary and sufficient to maintain the KSHV episome. It also modulates viral and cellular transcription and has been implicated directly in oncogenesis because of its ability to bind to the p53 and pRb tumor suppressor proteins. Previously, we identified the LANA promoter (LANAp) and showed that it was positively regulated by LANA itself. Here, we present a detailed mutational analysis and define cis-acting elements and trans-acting factors for the core LANAp. We found that a downstream promoter element, TATA box, and GC box/Sp1 site at -29 are all individually required for activity. This architecture places LANAp into the small and unusual group of eukaryotic promoters that contain both the downstream promoter element and TATA element but lack a defined initiation site. Furthermore, we demonstrate that LANA regulates its own promoter via its C-terminal domain and does bind to a defined site within the core promoter.
Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation
Creators: name: Cox, Adrienne D.
name: Rossman, Kent L.
name: Solski, Patricia A.
name: Sondek, John
name: Campbell, Sharon L.
name: Wilder, Rhonda S.
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Ect2 was identified originally as a transforming protein and a member of the Dbl family of Rho guanine nucleotide exchange factors (GEFs). Like all Dbl family proteins, Ect2 contains a tandem Dbl homology (DH) and pleckstrin homology (PH) domain structure. Previous studies demonstrated that N-terminal deletion of sequences upstream of the DH domain created a constitutively activated, transforming variant of Ect2 (designated DeltaN-Ect2 DH/PH/C), indicating that the N terminus served as a negative regulator of DH domain function in vivo. The role of sequences C-terminal to the DH domain has not been established. Therefore, we assessed the consequences of mutation of C-terminal sequences on Ect2-transforming activity. Surprisingly, in contrast to observations with other Dbl family proteins, we found that mutation of the invariant tryptophan residue in the PH domain did not impair DeltaN-Ect2 DH/PH/C transforming activity. Furthermore, although the sequences C-terminal to the PH domain lack any known functional domains or motifs, deletion of these sequences (DeltaN-Ect2 DH/PH) resulted in a dramatic reduction in transforming activity. Whereas DeltaN-Ect2 caused formation of lamellipodia, DeltaN-Ect2 DH/PH enhanced actin stress fiber formation, suggesting that C-terminal sequences influenced Ect2 Rho GTPase specificity. Consistent with this possibility, we determined that DeltaN-Ect2 DH/PH activated RhoA, but not Rac1 or Cdc42, whereas DeltaN-Ect2 DH/PH/C activated all three Rho GTPases in vivo. Taken together, these observations suggest that regions of Ect2 C-terminal to the DH domain alter the profile of Rho GTPases activated in vivo and consequently may contribute to the enhanced transforming activity of DeltaN-Ect2 DH/PH/C.
(1686) Helen Elizabeth [Turner]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Composition of Transfer Matrices for Potentials with Overlapping Support
Creators: name: Loran, Farhang
name: Mostafazadeh, Ali
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: For a pair of real or complex scattering potentials $v_j:\mathbb{R}\to\mathbb{C}$ ($j=1,2$) with support $I_j$ and transfer matrix $M_j$, the transfer matrix of $v_1+v_2$ is given by the product $M_2 M_1$ provided that $I_1$ lies to the left of $I_2$. We explore the prospects of generalizing this composition rule for the cases that $I_1$ and $I_2$ have a small intersection. In particular, we show that if $I_1$ and $I_2$ intersect in a finite closed interval of length $\ell$ in which both the potentials are analytic, then the lowest order correction to the above composition rule is proportional to $\ell^5$. This correction is of the order of $\ell^3$, if $v_1$ and $v_2$ are respectively analytic throughout this interval except at $x=\ell$ and $x=0$. We use these results to explore the superposition of a pair of unidirectionally invisible potentials with overlapping support.
description: 14 pages, 1 figure
(1688) Clement Stone Wigg
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary material 1 from Reporting of thermography parameters in biology: a systematic review of thermal imaging literature.
Creators: name: Harrap, Michael J. M.
name: Ibarra, Natalie Hempel De
name: Whitney, Heather M.
name: Rands, Sean A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: The Web of Science search employed in our systematic review
Oscillation of heavy sterile neutrino in decay of $B \to μe π$
Creators: name: Cvetic, Gorazd
name: Kim, C. S.
name: Kogerler, Reinhart
name: Zamora-Saa, Jilberto
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In a scenario with two almost mass degenerate heavy sterile Majorana neutrinos with a mass $\sim 1$ GeV, we present the semileptonic decay widths of heavy charged pseudoscalars such as $B$ mesons, either lepton-number-violating ($B^{\pm} \to μ^{\pm} e^{\pm} π^{\mp}$), or lepton-number-conserving ($B^{\pm} \to μ^{\pm} e^{\mp} π^{\pm}$), mediated by such on-shell neutrinos. It had been explained in the literature that such decays may be eventually detected, and that they can present even detectable CP violation effects. In this work we point out that, in addition, such decays may present detectable effects of heavy neutrino oscillation, allowing us to extract the oscillation length and thus the heavy neutrino mass difference $ΔM_N$, as well as a CP-violating Majorana phase.
description: 18 pages,7 figures; minor improvements in presentation; the last paragraph in Sec.III is new; new Sec. V; Refs.[6a] and [27] are new; published in PRD
(1683) William Pollock Henderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary material 1 from Reporting of thermography parameters in biology: a systematic review of thermal imaging literature
Creators: name: Harrap, Michael J. M.
name: Ibarra, Natalie Hempel De
name: Whitney, Heather M.
name: Rands, Sean A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: The Web of Science search employed in our systematic review
RhoA Activates Purified Phospholipase C-ϵ by a Guanine Nucleotide-dependent Mechanism
Creators: name: Sondek, John
name: Gershburg, Svetlana
name: Wing, Michele R.
name: Seifert, Jason P.
name: Snyder, Jason T.
name: Harden, T. Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Phospholipase C-epsilon (PLC-epsilon) is a recently identified PLC isoform activated by subunits of heterotrimeric G proteins (Galpha(12), Galpha(13), and Gbetagamma) as well as by the low molecular weight GTPases, Rho and Ras. To define the enzymatic activity and substrate specificity of PLC-epsilon as well as its potential direct activation by Rho family GTPases, a major fragment of PLC-epsilon encompassing the catalytic core (EF-hand repeats through the tandem Ras-associating domains; approximately 118 kDa) was purified to near homogeneity and assayed after reconstitution under various conditions. Similar to the enzymatic profiles of previously purified PLC-beta isozymes, the purified fragment of PLC-epsilon maximally hydrolyzed phosphatidylinositol 4-phosphate at a rate of approximately 10 mumol/mg of protein/min, exhibited phospholipase activity dependent on the concentration of free calcium, and favored phosphatidylinositol 4,5-bisphosphate as substrate relative to other phosphoinositides. Furthermore, in mixed detergent phospholipid micelles, RhoA stimulated the phospholipase activity of the PLC-epsilon fragment in both a concentration-dependent and guanosine 5'-O-(3-thiotriphosphate)-dependent manner. This activation was abolished by the deletion of a unique approximately 65 amino acid-insert within the catalytic core of PLC-epsilon. Although Rac1 activated purified PLC-beta2ina guanine nucleotide-dependent manner, Rac1 failed to promote guanine nucleotide-dependent activation of purified PLC-epsilon. These results indicate that PLC-epsilon is a direct downstream effector for RhoA and that RhoA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase.
Recruitment of participants in multicentre surgical randomised controlled trials: a protocol for a comprehensive review of trials funded and published by the National Institute for Health and Care Research (NIHR) Health Technology Assessment (HTA) Programme
Creators: name: Mongelli, Gloria
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: RCTs
subject: Recruitment
subject: Surgery

description: This registration contains the protocol for this comprehensive review.
The Formation and Historical Implication of Cheonik Irrigation Association in Colonial Korea
Creators: name: Chung, Seungjin
name: Chung, Seungjin
Publisher: name: Unknown
Year: 2009
Subjects: subject: Resource /Energy Economics and Policy
subject: irrigation
subject: Mangyong River
subject: water project

description: This paper is to clarify the formation of early irrigation associations in the colonial Korea, focusing on the case study of Chonik(全益) Irrigation Association. From the early 1910s, there used to be a traditional-style irrigation system called bo(洑) in Ch’unp’o myon, Iksan County, Jeonbuk province. Chonik Association was little innovative in irrigation techniques, but it brought about certain important changes in managing the institution. First of all, it was the Japanese rather than Koreans who initiated a modern system of association. Chonik Association carried out large river projects for regional development too. The Mangyong River improvement project started in its middle reach in 1925. The initial project was further extended by five years to develop the lower reach and a tributary(Iksan Stream) of the river as well. This water project combined with the irrigation project enhanced much a synergic effect. However, given the well-established and highly effective irrigation association, the regional rural society far surpassed other ordinary Korean villages in agricultural environments. The dilemma of the colonial development was that as their influences in the region deepened, so the gap between them and neighboring villages widened.
(1684) Fanny G [Chadwick]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Ring1b-mediated H2A Ubiquitination Associates with Inactive X Chromosomes and Is Involved in Initiation of X Inactivation
Creators: name: Chen, Taiping
name: Chadwick, Brian
name: Fang, Jia
name: Li, En
name: Zhang, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Histone modifications are thought to serve as epigenetic markers that mediate dynamic changes in chromatin structure and regulation of gene expression. As a model system for understanding epigenetic silencing, X chromosome inactivation has been previously linked to a number of histone modifications including methylation and hypoacetylation. In this study, we provide evidence that supports H2A ubiquitination as a novel epigenetic marker for the inactive X chromosome (Xi) and links H2A ubiquitination to initiation of X inactivation. We found that the H2A-K119 ubiquitin E3 ligase Ring1b, a Polycomb group protein, is enriched on Xi in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. Consistent with Ring1b mediating H2A ubiquitination, ubiquitinated H2A (ubH2A) is also enriched on the Xi of both TS and ES cells. We demonstrate that the enrichment of Ring1b and ubH2A on Xi is transient during TS and ES cell differentiation, suggesting that the Ring1b and ubH2A are involved in the initiation of both imprinted and random X inactivation. Furthermore, we showed that the association of Ring1b and ubH2A with Xi is mitotically stable in non-differentiated TS cells.
Optimal control of a buoyancy-driven liquid steel stirring modeled with single-phase Navier--Stokes equations
Creators: name: Wilbrandt, Ulrich
name: Alia, Najib
name: John, Volker
Publisher: name: Weierstrass Institute
Year: 2020
Subjects: subject: ladle stirring
subject: single-phase Navier--Stokes equations
subject: turbulent incompressible flows
subject: optimal control of PDEs
subject: finite element method
subject: 65M60
subject: 76F65

description: Gas stirring is an important process used in secondary metallurgy. It allows to homogenize the temperature and the chemical composition of the liquid steel and to remove inclusions which can be detrimental for the end-product quality. In this process, argon gas is injected from two nozzles at the bottom of the vessel and rises by buoyancy through the liquid steel thereby causing stirring, i.e., a mixing of the bath. The gas flow rates and the positions of the nozzles are two important control parameters in practice. A continuous optimization approach is pursued to find optimal values for these control variables. The effect of the gas appears as a volume force in the single-phase incompressible NavierStokes equations. Turbulence is modeled with the Smagorinsky Large Eddy Simulation (LES) model. An objective functional based on the vorticity is used to describe the mixing in the liquid bath. Optimized configurations are compared with a default one whose design is based on a setup from industrial practice.
Selective Roles for Tumor Necrosis Factor α-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family: THE JUXTAMEMBRANE STALK DETERMINES CLEAVAGE EFFICIENCY
Creators: name: Hinkle, C. Leann
name: Loiselle, David
name: Lee, David C.
name: Russell, William E.
name: Sunnarborg, Susan W.
name: Stevenson, Mary
name: Parker, Carol E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Epidermal growth factor (EGF) family ligands are derived by proteolytic cleavage of the ectodomains of integral membrane precursors. Previously, we established that tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) is a physiologic transforming growth factor-alpha (TGF-alpha) sheddase, and we also demonstrated enhanced shedding of amphiregulin (AR) and heparin-binding (HB)-EGF upon restoration of TACE activity in TACE-deficient EC-2 fibroblasts. Here we extended these results by showing that purified soluble TACE cleaved single sites in the juxtamembrane stalks of mouse pro-HB-EGF and pro-AR ectodomains in vitro. For pro-HB-EGF, this site matched the C terminus of the purified human growth factor, and we speculate that the AR cleavage site is also physiologically relevant. In contrast, ADAM9 and -10, both implicated in HB-EGF shedding, failed to cleave the ectodomain or cleaved at a nonphysiologic site, respectively. Cotransfection of TACE in EC-2 cells enhanced phorbol myristate acetate-induced but not constitutive shedding of epiregulin and had no effect on betacellulin (BTC) processing. Additionally, soluble TACE did not cleave the juxtamembrane stalks of either pro-BTC or pro-epiregulin ectodomains in vitro. Substitution of the shorter pro-BTC juxtamembrane stalk or truncation of the pro-TGF-alpha stalk to match the pro-BTC length reduced TGF-alpha shedding from transfected cells to background levels, whereas substitution of the pro-BTC P2-P2' sequence reduced TGF-alpha shedding less dramatically. Conversely, substitution of the pro-TGF-alpha stalk or lengthening of the pro-BTC stalk, especially when combined with substitution of the pro-TGF-alpha P2-P2' sequence, markedly increased BTC shedding. These results indicate that efficient TACE cleavage is determined by a combination of stalk length and scissile bond sequence.
ESM Methods detailed from Stress behaviour and physiology of developing Arctic barnacle goslings (Branta leucopsis) is affected by legacy trace contaminants.
Creators: name: Scheiber, Isabella B. R.
name: Weiß, Brigitte M.
name: Jong, Margje E. D.
name: Braun, Anna
name: Brink, Nico W. V. D.
name: Loonen, Maarten J. J. E.
name: Millesi, Eva
name: Komdeur, Jan
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: 60801 Animal Behaviour

description: Detailed description of behaviours during stress tests, dropping collections for baseline and stress induced corticosterone metabolites (CORTm), statistical analyses, and ESM relevant literature.
(1681) John Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On the growth rate of a linear stochastic recursion with Markovian dependence
Creators: name: Pirjol, Dan
name: Zhu, Lingjiong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider the linear stochastic recursion $x_{i+1} = a_{i}x_{i}+b_{i}$ where the multipliers $a_i$ are random and have Markovian dependence given by the exponential of a standard Brownian motion and $b_{i}$ are i.i.d. positive random noise independent of $a_{i}$. Using large deviations theory we study the growth rates (Lyapunov exponents) of the positive integer moments $λ_q = \lim_{n\to \infty} \frac{1}{n} \log\mathbb{E}[(x_n)^q]$ with $q\in \mathbb{Z}_+$. We show that the Lyapunov exponents $λ_q$ exist, under appropriate scaling of the model parameters, and have non-analytic behavior manifested as a phase transition. We study the properties of the phase transition and the critical exponents using both analytic and numerical methods.
description: 39 pages, 4 figures
ESM Results detailed from Stress behaviour and physiology of developing Arctic barnacle goslings (Branta leucopsis) is affected by legacy trace contaminants.
Creators: name: Scheiber, Isabella B. R.
name: Weiß, Brigitte M.
name: Jong, Margje E. D.
name: Braun, Anna
name: Brink, Nico W. V. D.
name: Loonen, Maarten J. J. E.
name: Millesi, Eva
name: Komdeur, Jan
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: 60801 Animal Behaviour

description: Figure 1: Daily mean mass of control and exposed goslings. 2: Reanalysis of group cohesion during the group isolation with a potential outlier excluded (see also Fig. 2b in the publication).
Magnetic monopole - domain wall collisions
Creators: name: Brush, Micah
name: Pogosian, Levon
name: Vachaspati, Tanmay
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Interactions of different types of topological defects can play an important role in the aftermath of a phase transition. We study interactions of fundamental magnetic monopoles and stable domain walls in a Grand Unified theory in which $SU(5) \times Z_2$ symmetry is spontaneously broken to $SU(3)\times SU(2)\times U(1)/Z_6$. We find that there are only two distinct outcomes depending on the relative orientation of the monopole and the wall in internal space. In one case, the monopole passes through the wall, while in the other it unwinds on hitting the wall.
description: 8 pages, 7 figures; new title and minor changes; matches the version accepted to Phys Rev D
Speriolin Is a Novel Spermatogenic Cell-specific Centrosomal Protein Associated with the Seventh WD Motif of Cdc20
Creators: name: Goto, Masuo
name: Eddy, Edward M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The fundamental mechanisms of mitosis are conserved throughout evolution in eukaryotes, including ubiquitin-mediated proteolysis of cell cycle regulators by the anaphase-promoting complex/cyclosome. The spindle checkpoint protein Cdc20 activates the anaphase-promoting complex/cyclosome in a substrate-specific manner. It is present in the cytoplasm and concentrated in the centrosomes throughout the cell cycle, accumulates at the kinetochores in metaphase, and is no longer detected following anaphase. However, it is unknown whether Cdc20 has the same activities and distribution during meiosis in male germ cells. We found that in mice, Cdc20 accumulates in the cytoplasm of pachytene spermatocytes during meiosis I, is distributed throughout spermatocytes undergoing meiotic division, and is present in the cytoplasm of postmeiotic spermatids. Several proteins bind to and regulate the function of Cdc20 during mitosis. We identified speriolin and determined that it is a novel spermatogenic cell-specific Cdc20-binding protein, is present in the cytoplasm, and is concentrated at the centrosomes of spermatocytes and spermatids and that a leucine zipper domain is required to target speriolin to the centrosome. The seven tandem WD motifs of Cdc20 probably fold into a seven-blade beta-propeller structure, and we determined that they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells.
Thermodynamic of universe with a varying dark energy component
Creators: name: Ebadi, H.
name: Moradpour, H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider a FRW universe filled by a dark energy candidate together with other possible sources which may include the baryonic and non-baryonic matters. Thereinafter, we consider a situation in which the cosmos sectors do not interact with each other. By applying the unified first law of thermodynamics on the apparent horizon of the FRW universe, we show that the dark energy candidate may modify the apparent horizon entropy and thus the Bekenstein limit. Moreover, we generalize our study to the models in which the cosmos sectors have a mutual interaction. Our final result indicates that the mutual interaction between the cosmos sectors may add an additional term to the apparent horizon entropy leading to modify the Bekenstein limit. Relationships with previous works have been addressed throughout the paper. Finally, we investigate the validity of the second law of thermodynamics and its generalized form in the interacting and non-interacting cosmoses.
description: Accepted for Publishing in IJMPD
Quantisation of the holographic Ricci dark energy model
Creators: name: Albarran, Imanol
name: Bouhmadi-López, Mariam
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: While general relativity is an extremely robust theory to describe the gravitational interaction in our Universe, it is expected to fail close to singularities like the cosmological ones. On the other hand, it is well known that some dark energy models might induce future singularities; this can be the case for example within the setup of the Holographic Ricci Dark Energy model (HRDE). On this work, we perform a cosmological quantisation of the HRDE model and obtain under which conditions a cosmic doomsday can be avoided within the quantum realm. We show as well that this quantum model not only avoid future singularities but also the past Big Bang.
description: 10 pages, RevTex4-1. Expanded and improved discussion. Version accepted in JCAP
ESM Methods detailed from Stress behaviour and physiology of developing Arctic barnacle goslings (Branta leucopsis) is affected by legacy trace contaminants
Creators: name: Scheiber, Isabella B. R.
name: Weiß, Brigitte M.
name: Jong, Margje E. D.
name: Braun, Anna
name: Brink, Nico W. V. D.
name: Loonen, Maarten J. J. E.
name: Millesi, Eva
name: Komdeur, Jan
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: 60801 Animal Behaviour

description: Detailed description of behaviours during stress tests, dropping collections for baseline and stress induced corticosterone metabolites (CORTm), statistical analyses, and ESM relevant literature.
(1682) Francis Wilmer Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Shocks inside CMEs: A Survey of Properties from 1997 to 2006
Creators: name: Lugaz, N.
name: Farrugia, C. J.
name: Smith, C. W.
name: Paulson, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: We report on 49 fast-mode forward shocks propagating inside coronal mass ejections (CMEs) as measured by Wind and ACE at 1 AU from 1997 to 2006. Compared to typical CME-driven shocks, these shocks propagate in different upstream conditions, where the median upstream Alfv{é}n speed is 85 km s$^{-1}$, the proton $β= 0.08$ and the magnetic field strength is 8 nT. These shocks are fast with a median speed of 590 km s$^{-1}$ but weak with a median Alfv{é}nic Mach number of 1.9. They typically compress the magnetic field and density by a factor of 2-3. The most extreme upstream conditions found were a fast magnetosonic speed of 230 km s$^{-1}$, a plasma $β$ of 0.02, upstream solar wind speed of 740 km s$^{-1}$ and density of 0.5 cm$^{-3}$. Nineteen of these complex events were associated with an intense geomagnetic storm (peak Dst under $-100$ nT) within 12 hours of the shock detection at Wind, and fifteen were associated with a drop of the storm-time Dst index of more than 50 nT between 3 and 9 hours after shock detection. We also compare them to a sample of 45 shocks propagating in more typical upstream conditions. We show the average property of these shocks through a superposed epoch analysis, and we present some analytical considerations regarding the compression ratios of shocks in low $β$ regimes. As most of these shocks are measured in the back half of a CME, we conclude that about half the shocks may not remain fast-mode shocks as they propagate through an entire CME due to the large upstream and magnetosonic speeds.
description: Accepted to JGR, 17 pages, 2 tables, 10 figures
Identifying cosmological perturbations in group field theory condensates
Creators: name: Gielen, Steffen
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: One proposal for deriving effective cosmological models from theories of quantum gravity is to view the former as a mean-field (hydrodynamic) description of the latter, which describes a universe formed by a 'condensate' of quanta of geometry. This idea has been successfully applied within the setting of group field theory (GFT), a quantum field theory of 'atoms of space' which can form such a condensate. We further clarify the interpretation of this mean-field approximation, and show how it can be used to obtain a semiclassical description of the GFT, in which the mean field encodes a classical statistical distribution of geometric data. In this sense, GFT condensates are quantum homogeneous geometries that also contain statistical information about cosmological inhomogeneities. We show in the isotropic case how this information can be extracted from geometric GFT observables and mapped to quantities of observational interest. Basic uncertainty relations of (non-commutative) Fourier transforms imply that this statistical description can only be compatible with the observed near-homogeneity of the Universe if the typical length scale associated to the distribution is much larger than the fundamental 'Planck' scale. As an example of effective cosmological equations derived from the GFT dynamics, we then use a simple approximation in one class of GFT models to derive the 'improved dynamics' prescription of holonomy corrections in loop quantum cosmology.
description: 21 pages; v2: corrected minor typos, matches published version
Sphingosine 1-Phosphate Stimulates Smooth Muscle Cell Differentiation and Proliferation by Activating Separate Serum Response Factor Co-factors
Creators: name: Lockman, Kashelle
name: Hinson, Jeremiah S.
name: Morris, Dionne
name: Medlin, Matt D.
name: Taylor, Joan M.
name: Mack, Christopher P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Sphingosine 1-phosphate (S1P) is a lipid agonist that regulates smooth muscle cell (SMC) and endothelial cell functions by activating several members of the S1P subfamily of G-protein-coupled Edg receptors. We have shown previously that SMC differentiation is regulated by RhoA-dependent activation of serum response factor (SRF). Because S1P is a strong activator of RhoA, we hypothesized that S1P would stimulate SMC differentiation. Treatment of primary rat aortic SMC cells with S1P activated RhoA as measured by precipitation with a glutathione S-transferase-rhotekin fusion protein. In SMC and 10T1/2 cells, S1P treatment up-regulated the activities of several transiently transfected SMC-specific promoters, and these effects were inhibited by the Rho-kinase inhibitor, Y-27632. S1P also increased smooth muscle alpha-actin protein levels in SMC but had no effect on SRF binding to the smooth muscle alpha-actin CArG B element. Quantitative reverse transcriptase-PCR showed that S1P treatment of SMC or 10T1/2 cells did not increase the mRNA level of either of the recently identified SRF co-factors, myocardin or myocardin-related transcription factor-A (MRTF-A). MRTF-A protein was expressed highly in SMC and 10T1/2 cultures, and importantly the effects of S1P were inhibited by a dominant negative form of MRTF-A indicating that S1P may regulate the transcriptional activity of MRTF-A. Indeed, S1P treatment increased the nuclear localization of FLAG-MRTF-A, and the effect of MRTF-A overexpression on smooth muscle alpha-actin promoter activity was inhibited by dominant negative RhoA. S1P also stimulated SMC growth by activating the early growth response gene, c-fos. This effect was not attenuated by Y-27632 but could be inhibited by the MEK inhibitor, UO126. S1P enhanced SMC growth through ERK-mediated phosphorylation of the SRF co-factor, Elk-1, as measured by gel shift and Elk-1 activation assays. Taken together these results demonstrate that S1P activates multiple signaling pathways in SMC and regulates proliferation by ERK-dependent activation of Elk-1 and differentiation by RhoA-dependent activation of MRTF-A.
ESM Results detailed from Stress behaviour and physiology of developing Arctic barnacle goslings (Branta leucopsis) is affected by legacy trace contaminants
Creators: name: Scheiber, Isabella B. R.
name: Weiß, Brigitte M.
name: Jong, Margje E. D.
name: Braun, Anna
name: Brink, Nico W. V. D.
name: Loonen, Maarten J. J. E.
name: Millesi, Eva
name: Komdeur, Jan
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: 60801 Animal Behaviour

description: Figure 1: Daily mean mass of control and exposed goslings. 2: Reanalysis of group cohesion during the group isolation with a potential outlier excluded (see also Fig. 2b in the publication).
(1677) James Henry Moore
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
details of behaviour classification methods from Migrating ospreys use thermal uplift over the open sea.
Creators: name: Duriez, Olivier
name: PERON, Guillaume
name: Gremillet, David
name: Sforzi, Andrea
name: Monti, Flavio
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Most large raptors on migration avoid crossing the sea because of the lack of atmospheric convection over temperate seas. The osprey Pandion haliaetus is an exception among raptors, since it can fly over several hundred kilometres of open water. We equipped five juvenile ospreys with GPS-Accelerometer-Magnetometer loggers. All birds were able to find and use thermal uplift while crossing the Mediterranean Sea, on average 7.5 times per 100 km, and could reach altitudes of 900 m above the sea surface. Their climb rate was 1.6 times slower than over land, and birds kept flapping most of the time while circling in the thermals, indicating that convections cells were weaker than over land. The frequency of thermal soaring was correlated with the difference between the sea surface and air temperature, indicating that atmospheric convection occurred when surface waters were warmer than the overlaying air. These observations help explain the transoceanic cosmopolitan distribution of osprey, and question the widely held assumption that water bodies represent strict barriers for large raptors.
Taz1 Binding to a Fission Yeast Model Telomere: FORMATION OF TELOMERIC LOOPS AND HIGHER ORDER STRUCTURES
Creators: name: Willcox, Smaranda
name: Slezakova, Judita
name: Griffith, Jack D.
name: Nosek, Jozef
name: Tomaska, Lubomir
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Similar to its human homologues TRF1 and TRF2, fission yeast Taz1 protein is a component of telomeric chromatin regulating proper telomere maintenance. As mammalian TRF1 and TRF2 proteins have been shown to directly bind telomeric DNA to form protein arrays and looped structures, termed t-loops, the ability of Taz1p to act on fission yeast telomeric DNA in similar ways was examined using purified protein and model DNA templates. When incubated with Taz1p, model telomeres containing 3' single-stranded telomeric overhangs formed t-loops at a frequency approaching 13%. Termini with blunt ends and non-telomeric overhangs were deficient in t-loop formation. In addition, we observed arrays of multiple Taz1p molecules bound to the telomeric regions, resembling the pattern of TRF1 binding. The presence of t-loops larger than the telomeric tract, a high frequency of end-bound DNAs and a donut shape of the Taz1p complex suggest that Taz1p binds the 3' overhang then extrudes a loop that grows in size as the donut slides along the duplex DNA. Based on these in vitro results we discuss possible general implications for fission yeast telomere dynamics.
Termination of Protease-activated Receptor-1 Signaling by β-Arrestins Is Independent of Receptor Phosphorylation
Creators: name: Paing, May M.
name: Chen, Chii Heui
name: Trejo, Jo Ann
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Protease-activated receptor 1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, is the prototypic member of a family of protease-activated receptors. PAR1 is irreversibly proteolytically activated; thus, the magnitude and duration of thrombin cellular responses are determined primarily by mechanisms responsible for termination of receptor signaling. Both phosphorylation and beta-arrestins contribute to rapid desensitization of PAR1 signaling. However, the relative contribution of each of these pathways to the termination of PAR1 signaling is not known. Co-expression of PAR1 with beta-arrestin 1 (betaarr1) in COS-7 cells resulted in a marked inhibition of PAR1 signaling, whereas beta-arrestin 2 (betaarr2) was essentially inactive. Strikingly, signaling by a PAR1 cytoplasmic tail mutant defective in agonist-induced phosphorylation was also attenuated more effectively by betaarr1 compared with betaarr2. In contrast, both beta-arrestin isoforms were equally effective at desensitizing the substance P receptor, a classic reversibly activated GPCR. PAR1 coimmunoprecipitated betaarr1 in an agonist-dependent manner, whereas betaarr2 association was virtually undetectable. Remarkably, betaarr1 also interacted with phosphorylation defective PAR1 mutant, whereas betaarr2 did not. Moreover, constitutively active beta-arrestin mutants, betaarr1 R169E and betaarr2 R170E, that bind to activated receptor independent of phosphorylation failed to enhance either wild type or mutant PAR1 desensitization compared with normal versions of these proteins. In contrast, beta-arrestin mutants displayed enhanced activity at desensitizing the serotonin 5-hydroxytryptamine(2A) receptor. Taken together, these results suggest that, in addition to PAR1 cytoplasmic tail phosphorylation itself, beta-arrestin binding independent of phosphorylation promotes desensitization of PAR1 signaling. These findings reveal a new level of complexity in the regulation of protease-activated GPCR signaling.
Invariant approach to CP in unbroken $Δ(27)$
Creators: name: Branco, Gustavo C.
name: Varzielas, Ivo de Medeiros
name: King, Stephen F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The invariant approach is a powerful method for studying CP violation for specific Lagrangians. The method is particularly useful for dealing with discrete family symmetries. We focus on the CP properties of unbroken $Δ(27)$ invariant Lagrangians with Yukawa-like terms, which proves to be a rich framework, with distinct aspects of CP, making it an ideal group to investigate with the invariant approach. We classify Lagrangians depending on the number of fields transforming as irreducible triplet representations of $Δ(27)$. For each case, we construct CP-odd weak basis invariants and use them to discuss the respective CP properties. We find that CP violation is sensitive to the number and type of $Δ(27)$ representations.
description: 24 pages, 1 figure. v2: to be published in NPB
Projeto Integridade GRU - O QUE O VEREADOR ESTÁ FAZENDO?
Creators: name: Tavares, Rodrigo
name: Altieres De Oliveira Silva
Publisher: name: Zenodo
Year: 2019
Subjects: Câmara Municipal guarulhense
vereadores
PORTAL DA TRANSFERÊNCIA
Guarulhos
governança

description: O poder legislativo do município da cidade Guarulhense é exercido pela câmara municipal, composta por 34 vereadores eleitos democraticamente. Uma pesquisa realizada pelo Tribunal de Contas do Estado de São Paulo -, mapeou os gastos públicos de todas as câmaras paulistas. Infelizmente, a câmara municipal guarulhense ficou entre as mais caras do Brasil, com um custo médio de R$ 97 milhões por ano (JORNAL DA BAND, 2019).
(1678) John Stone Wigg
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Epstein-Barr Virus Polymerase Accessory Factor BMRF1 Adopts a Ring-shaped Structure as Visualized by Electron Microscopy
Creators: name: Griffith, Jack D.
name: Makhov, Alexander M.
name: Subramanian, Deepa
name: Kenney, Shannon C.
name: Holley-Guthrie, Elizabeth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Epstein-Barr virus (EBV) encodes a set of core replication factors used during lytic infection in human cells that parallels the factors used in many other systems. These include a DNA polymerase and its accessory factor, a helicase/primase, and a single strand binding protein. The EBV polymerase accessory factor has been identified as the product of the BMRF1 gene and has been shown by functional assays to increase the activity and processivity of the polymerase. Unlike other members of this class of factors, BMRF1 is also a transcription factor regulating certain EBV genes. Although several polymerase accessory factors, including eukaryotic proliferating cell nuclear antigen, Escherichia coli beta protein, and T4 gene 45 protein have been shown to form oligomeric rings termed sliding clamps, nothing is known about the oligomeric state of BMRF1 or whether it forms a ring. In this work, BMRF1 was purified directly from human cells infected with an adenovirus vector expressing the BMRF1 gene product. The protein was purified to near homogeneity, and examination by negative staining electron microscopy revealed large, flat, ring-shaped molecules with a diameter of 15.5 +/- 0.8 nm and a distinct 5.3-nm diameter hole in the center. The size of these rings is consistent with an oligomer of 6 monomers, nearly twice as large as the trimeric proliferating cell nuclear antigen ring. Unlike the herpes simplex virus UL42 homologue, BMRF1 was found to self-associate in solution. These findings extend the theme of polymerase accessory factors adopting ring-shaped structures and provide an example in which the ring is significantly larger than any previously described sliding clamp.