cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 9 of FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia
Creators: name: Zhu, Xiao-Na
name: Wei, Yu-Sheng
name: Yang, Qian
name: Liu, Hao-Ran
name: Zhi, Zhe
name: Zhu, Di
name: Xia, Li
name: Hong, Deng-Li
name: Yu, Yun
name: Chen, Guo-Qiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Cancer
subject: Hematology

description: Additional file 9. Uncropped Western blots
Unsustainable hospital charges are incurred in the treatment of Medicare beneficiaries admitted with subarachnoid hemorrhage
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Introduction—Rising medical care expenditures and the unchanging Medicare reimbursements have placed restraints on the health care delivery system. Objective—The goal of this study is to identify the magnitude and determinants of discrepancy between hospitalization charges and Medicare re-imbursement observed in the management of Medicare beneficiaries admitted with aneurysmal subarachnoid hemorrhage in the United States. Methods—Patients entered in the Nationwide Inpatient Sample between 2002 and 2010, with a ruptured intracranial aneurysm who underwent either surgical or endovascular treatment were included in the study. Factors associated with higher discrepancy between hospitalization charges and Medicare re-imbursement were identified. Results—Discrepancies in hospital charges and Medicare reimbursement associated with endovascular and surgical treatment have increased over the decade. The median discrepancy per patient for Medicare patients aged 65 years and older treated surgically or endovascularly for a ruptured aneurysm from 2009 to 2010 was $177,380. The predictors of higher than median discrepancy(charges versus reimbursement), included Hispanic ethnicity (OR 2.1, 95% CI 1.1–3.9, p = 0.02), urinary tract infection (OR 2.0, 95% CI 1.4–2.8, p = <0.001), pneumonia (OR 3.0, 95% CI 1.8–4.8, p = <0.001), deep vein thrombosis (OR 2.5, 95% CI 1.2–5.2, p = 0.02), and pulmonary embolism (OR 18, 95% CI 2.0–169, pp = 0.01). Conclusions—There is a growing gap between hospital charges and Medicare reimbursement. If hospitals continue to be reimbursed at significantly lower rates than charges incurred, this current system may be unsustainable due to losses incurred by hospitals.
“That’s the Work”: Reframing Talk during Meetings
Creators: name: Milburn, Trudy
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2012

description: Conversation analysts often examine everyday interaction for the micro-features that comprise talk. Often, these micro-features are labeled and transcend any one instance. Some genres of talk have been examined to see if patterned speech occurs within that genre. For instance, a typical business event, such as a meeting or strategic planning process, may indicate particular ways of speaking. In Drew and Heritage’s (1992) edited volume, Talk at Work, each chapter employs CA to detail features of talk in a variety of institutional settings. Schwartzman’s (1989) work on the business meeting illustrates clearly the boundaries of what counts as a meeting, and how the participants and their various roles work to create this demarcation. Finally, in The Business of Talk, Boden (1994) uses CA to closely examine the turns that members take that influence the outcome of meetings.
description: Studies in Applied Linguistics and TESOL, Vol. 12 No. 1 (2012)
“You Can Make a Tower”: Using Conversation Analysis to Understand a Math Tutoring Session
Creators: name: Creider, Sarah
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2012

description: A recent article in the New York Times (Spencer, 2011) described a series of well-attended workshops on how to encourage children to play effectively with wooden blocks. At first glance, the idea of teaching children to play seems somewhat absurd. And yet, if we think about learning via play rather than learning to play, it is reasonable to ask how adults can encourage mathematical and verbal complexity in children’s games and activities. By looking closely at what parents and teachers say to children during play sessions, we can perhaps better understand the kind of language that supports intellectual development in the context of child-directed play. In this brief paper, I attempt to show how one teacher uses language to bring together learning and play in a math tutoring session. Specifically, I discuss an instance where the teacher finds a moment in a student’s self-directed game where it would be appropriate to introduce beginning math concepts.
description: Studies in Applied Linguistics and TESOL, Vol. 12 No. 1 (2012)
THE MAIN APPROACHES TO THE SEMANTIC CLASSIFICATION OF BEHAVIORAL VERBS IN THE SCIENTIFIC LITERATURE
Creators: name: Alimuhammedova, K.R.
Publisher: name: Zenodo
Year: 2023

description: From birth to old age, a person communicates with his type, performs certain actions. The set of principles of behavior in which a single person reacts to the life of society is called social behavior. The peculiarities of behavior, human relations with other people are reflected in the oral dictionary, which is a socially significant branch of the national picture of the world.
Quantization for an elliptic equation of order 2m with critical exponential non-linearity
Creators: name: Martinazzi, Luca
name: Struwe, Michael
Publisher: name: arXiv
Year: 2010
Subjects: subject: Functional Analysis (math.FA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: On a smoothly bounded domain $Ω\subset\R{2m}$ we consider a sequence of positive solutions $u_k\stackrel{w}{\rightharpoondown} 0$ in $H^m(Ω)$ to the equation $(-Δ)^m u_k=λ_k u_k e^{mu_k^2}$ subject to Dirichlet boundary conditions, where $0
description: 33 pages
Case A or Case B? The effective recombination coefficient in gas clouds of arbitrary optical thickness
Creators: name: Nebrin, Olof
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In calculations of the ionization state, one is often forced to choose between the Case A recombination coefficient $α_{\rm A}$ (sum over recombinations to all hydrogen states) or the Case B recombination coefficient $α_{\rm B}$ (sum over all hydrogen states except the ground state). If the cloud is optically thick to ionizing photons, $α_{\rm B}$ is usually adopted on the basis of the "on-the-spot" approximation, wherein recombinations to the ground state are ignored because they produce ionizing photons absorbed nearby. In the opposite case of an optically thin cloud, one would expect the Case A recombination coefficient to better describe the effective recombination rate in the cloud. In this paper, I derive an analytical expression for the effective recombination coefficient in a gas cloud of arbitrary optical thickness which transitions from $α_{\rm A}$ to $α_{\rm B}$ as the optical thickness increases. The results can be readily implemented in numerical simulations and semi-analytical calculations.
description: 4 pages, 1 figure. Accepted for publication in RNAAS
On Language Teachers’ Classroom Practices: Bridging Conversation Analysis with Language Teacher Education Research
Creators: name: Fagan, Drew S.
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2012

description: Since the late 1980s, second language teacher education (SLTE) research has grown immensely as a field of inquiry within applied linguistics, particularly as teacher knowledge, expertise, and cognition have been found to influence students’ language learning processes in classroom contexts (Borg, 2011). Much empirical evidence illustrating this connection has been gathered using a variety of ethnographic data techniques such as individual interviews, focus groups, journal writing, questionnaires, field notes, and stimulated recall sessions. The strengths of these data sources are numerous in that, when triangulated, they provide insight into teachers’ thought processes and perceptions of their teaching practices. It has been asserted elsewhere (see Fagan, in press a), though, that while many studies within the SLTE field have attempted to draw implications from such findings for teachers’ classroom practices, the methods used do not allow for such assumptions. In fact, as Borg (2011) presents in his summary of SLTE research over the past two decades, there remains a lack of juxtaposition between findings on teachers’ perceptions and their actual classroom practices in situ.
description: Studies in Applied Linguistics and TESOL, Vol. 12 No. 1 (2012)
Applying Conversation Analysis to Real-world Concerns
Creators: name: Box, Catherine
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2012

description: A few weeks ago, I sat in the audience of an atypical professional panel at an uplifting conference. The panel and audience members, all enthusiastic alumni and students of my alma mater’s English Department, were discussing the career paths they had (or had not) chosen since college graduation. There were contributions from two lawyers, two English teachers, a global corporate chairman, and a few graduate students, as well as a smattering of undergraduates who were eager and anxious to learn more about possible job opportunities. Despite our diverse backgrounds and at times contentious conversation, we left that conference room having agreed on at least one thing: successful professionals are exceptional analysts. Someone who builds a principled argument in the courtroom, the boardroom, the classroom, or any other room, will go a long way. I had remarked that knowing how to analyze hinges on not only being able to build arguments, but also on being able to break them down. In order to critically engage with or respond to a piece of text, one must understand it in a deep sense, and mull over the connections within or between the lines. From intricate exploration comes enlightening analysis, no matter the context.
description: Studies in Applied Linguistics and TESOL, Vol. 12 No. 1 (2012)
Child Second Language Acquisition: What Do We Know?
Creators: name: Miller, Andrew
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2012

description: Despite the growing number of research studies in recent years, what is known about child second language acquisition (SLA) remains by and large a fraction of what is still to be known. In the present review, child SLA is defined as pertinent to both second language (L2) and sequential bilingual learners between the ages of two and twelve. Studies undertaken over the past 15 years are subdivided by paradigm (i.e., the generativists, the emergentists, the psycholinguists, and the neurocognitivists) and then thoroughly discussed. These studies are presented and critiqued in such a way that the significant holes persisting in our general understanding of child SLA will become apparent.
description: Studies in Applied Linguistics and TESOL, Vol. 12 No. 1 (2012)
Effects of a phase transition on HBT correlations in an integrated Boltzmann+Hydrodynamics approach
Creators: name: Li, Qingfeng
name: Steinheimer, Jan
name: Petersen, Hannah
name: Bleicher, Marcus
name: Stoecker, Horst
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A systematic study of HBT radii of pions, produced in heavy ion collisions in the intermediate energy regime (SPS), from an integrated (3+1)d Boltzmann+hydrodynamics approach is presented. The calculations in this hybrid approach, incorporating an hydrodynamic stage into the Ultra-relativistic Quantum Molecular Dynamics transport model, allow for a comparison of different equations of state retaining the same initial conditions and final freeze-out. The results are also compared to the pure cascade transport model calculations in the context of the available data. Furthermore, the effect of different treatments of the hydrodynamic freeze-out procedure on the HBT radii are investigated. It is found that the HBT radii are essentially insensitive to the details of the freeze-out prescription as long as the final hadronic interactions in the cascade are taken into account. The HBT radii $R_L$ and $R_O$ and the $R_O/R_S$ ratio are sensitive to the EoS that is employed during the hydrodynamic evolution. We conclude that the increased lifetime in case of a phase transition to a QGP (via a Bag Model equation of state) is not supported by the available data.
description: 7 pages, 5 figures. Accepted by Phys. Lett. B
Power, Position and Autonomy: Student Conflict in a Communicative Language Classroom
Creators: name: Hale, Chris Carl
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2012

description: Foreign language educators dedicated to facilitating a communicative classroom often express their satisfaction when their learners actively engage the target language with minimal teacher interference. However, with the nearly ubiquitous implementation of pair-and group-work activities in the language classroom, it is virtually impossible for even the most perceptive teachers to be cognizant of the dynamics of every conversation. Even in what may appear to be cooperative, equal participation in the completion of the task, conflicts, domination and marginalization of participants can emerge. In this study, a semi-autonomous learning environment in which students were placed in pairs to complete a learning task without the teacher present to mediate the student interaction was examined using Conversation Analysis (CA). It was found that the participants each attempted to be in control of the task and their partner by competing for the position of “the dominant knower,” resulting in a prolonged power struggle. The fact that the teacher was called in to settle their disagreements even inadvertently reinforced one student’s claim to the dominant position.
description: Studies in Applied Linguistics and TESOL, Vol. 12 No. 1 (2012)
Heat transfer from nanoparticles: a corresponding state analysis
Creators: name: Merabia, Samy
name: Shenogin, Serguei
name: Joly, Laurent
name: Keblinski, Pawel
name: Barrat, J. -L.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this contribution, we study situations in which nanoparticles in a fluid are strongly heated, generating high heat fluxes. This situation is relevant to experiments in which a fluid is locally heated using selective absorption of radiation by solid particles. We first study this situation for different types of molecular interactions, using models for gold particles suspended in octane and in water. As already reported in experiments, very high heat fluxes and temperature elevations (leading eventually to particle destruction) can be observed in such situations. We show that a very simple modeling based on Lennard-Jones interactions captures the essential features of such experiments, and that the results for various liquids can be mapped onto the Lennard-Jones case, provided a physically justified (corresponding state) choice of parameters is made. Physically, the possibility of sustaining very high heat fluxes is related to the strong curvature of the interface that inhibits the formation of an insulating vapor film.
The varieties for some Specht modules
Creators: name: Lim, Kay Jin
Publisher: name: arXiv
Year: 2009
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 20C30

description: We concern the VIGRE's conjecture; namely the complexity of a Specht module is the p-weight of the corresponding partition if and only if the partition is not p by p. In abelian defect case, we calculate the cohomological variety of the Specht modules. In particular, we show that the Specht modules have complexities exactly given by the p-weights of the corresponding partitions. For some p-regular partitions not more than p parts with empty p-core, we show that the Specht modules fit into the conjecture. For the partition p^p, we show that the Specht module has complexity p-1 and we study the rank variety of the Specht module restricted to a maximal elementary abelian p-subgroup of rank p.
description: to appear in Journal of Algebra
Measuring the parameters of massive black hole binary systems with Pulsar Timing Array observations of gravitational waves
Creators: name: Sesana, Alberto
name: Vecchio, Alberto
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The observation of massive black hole binaries (MBHBs) with Pulsar Timing Arrays (PTAs) is one of the goals of gravitational wave astronomy in the coming years. Massive (>10^8 solar masses) and low-redshift (< 1.5) sources are expected to be individually resolved by up-coming PTAs, and our ability to use them as astrophysical probes will depend on the accuracy with which their parameters can be measured. In this paper we estimate the precision of such measurements using the Fisher-information-matrix formalism. We restrict to "monochromatic" sources. In this approximation, the system is described by seven parameters and we determine their expected statistical errors as a function of the number of pulsars in the array, the array sky coverage, and the signal-to-noise ratio (SNR) of the signal. At fixed SNR, the gravitational wave astronomy capability of a PTA is achieved with ~20 pulsars; adding more pulsars (up to 1000) to the array reduces the source error-box in the sky ΔΩby a factor ~5 and has negligible consequences on the statistical errors on the other parameters. ΔΩimproves as 1/SNR^2 and the other parameters as 1/SNR. For a fiducial PTA of 100 pulsars uniformly distributed in the sky and a coherent SNR = 10, we find ΔΩ~40 deg^2, a fractional error on the signal amplitude of ~30% (which constraints only very poorly the chirp mass - luminosity distance combination M_c^{5/3}/D_L), and the source inclination and polarization angles are recovered at the ~0.3 rad level. The ongoing Parkes PTA is particularly sensitive to systems located in the southern hemisphere, where at SNR = 10 the source position can be determined with ΔΩ~10 deg^2, but has poorer performance for sources in the northern hemisphere. (Abridged)
description: 20 pages, 12 figures, 2 color figures, submitted to Phys. Rev. D
Some Unresolved Issues in an ELT New Media Age: Towards Building an Interlanguage Semantics
Creators: name: Lew, Adrienne Wai Man
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: On May 10, 2011, students from Professor ZhaoHong Han’s Advanced Second Language Acquisition (SLA) class in Spring 2011 had the honor of attending an invited seminar in which Professor Larry Selinker, was the honorary speaker.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Readers’ Credits for Volume 11, Issue 2
Creators: name: Lew, Adrienne Wai Man
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Teachers College, Columbia University Working Papers in TESOL & Applied Linguistics would like to thank the following individuals for reviewing the manuscripts for Volume 11, Issue 2 (2011).
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
The Roles of Attitude, Motivation, and Identity in Heritage Language Learning Among Korean Americans
Creators: name: Kong, Grace
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Much research has been conducted on learning English as an additional language both in the United States and around the world. However, there have been fewer studies focused on heritage language learners (HLLs) who have already acquired English as their native tongue and are learning their heritage language as an L2, or second language (Joo, 2009). The rapidly growing number of language minority individuals who have turned their attention towards learning their heritage languages have led both secondary schools and universities to restructure their foreign language classes in order to better address the needs of HLLs (Jensen & Llosa, 2007). Who exactly are HLLs and what defines them as such? What makes HLLs different from L2 learners? This paper will take a sociolinguistic and socio-psychological approach on HLLs with a particular focus on Korean Americans in the United States. How do attitude, motivation, and identity play a role in heritage language acquisition among Korean American learners? Do these socio-psychological factors affect one another in the learning process? What are the pedagogical implications for teachers and students?
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Impact of reimbursement restriction on drug market sales under the National Health Insurance in Japan
Creators: name: Mamiya, Hiroaki
name: Igarashi, Ataru
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: National health care expenditures have been increasing each year, although the Japanese government has annually revised official drug prices. Managing the health care system to pay for expensive drugs is a major concern. The reimbursement restriction, which is the only way that a drug can be implemented before market entry in Japan, is crucial for managing expenditures. Therefore, this study identifies the impact of the reimbursement restriction on drug market sales in Japan, particularly in the situation where health technology assessment or other market access regulations are not applicable before market entry. All new drugs listed in fiscal years 2011–2019, along with their market size forecast, were identified using the materials from the Central Social Insurance Medical Council. We then calculated the percentage rate of reimbursement amounts based on the National Database of Health Insurance Claims relative to the predicted market size as a dependent variable. Using the reimbursement restriction for each drug as an independent variable, we performed descriptive and univariate analyses on each variable, followed by generalized linear mixed-effects model regression analysis. We identified 211 drugs. The mean rates of drugs that required physicians, facilities, and patients to meet criteria for use were 30.85% (n = 2), 31.42% (n = 2), and 72.11% (n = 6), respectively. The mean rate of drugs that required diagnostic testing was 22.99% (n = 7), which was 3.7 times lower than the rate of drugs that did not require such testing (p Our results indicate that the reimbursement restriction requiring diagnostic testing has a substantial impact on decreasing market sales. As the number of cases for each requirement is small, further study is needed to measure the impact of the other reimbursement restrictions.
Dementia and Epistemic Authority: A Conversation Analytic Case Study
Creators: name: Black, Rebecca
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Imagine you have spent nearly all of the seventy years of your adult life being an organized and authoritative woman, raising three daughters, working as a clinical psychologist, maintaining many relationships and friendships. Now you’ve noticed more and more trouble remembering things, confusion about how to implement a plan or even what the right plan should be, even about things you know you used to do easily like shopping or making reservations. Imagine that, on top of all of this, one of those daughters you raised so competently is now sitting in front of you telling you that you’re so incompetent now that you don’t even know whether you’re capable of writing a letter to a friend. Recently, there has been much research applying the tools of discourse analysis to the talk of individuals with cognitive impairments (Cherney, Shadden, & Coelho, 1998). Many studies have examined the coherence, informational content, and topic management ability of older adults with various forms of dementia. In this case study I examine the interactions between a woman diagnosed with dementia of the Alzheimer’s type (DAT) and her daughter from a slightly different angle.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Automated Essay Scoring: A Literature Review
Creators: name: Blood, Ian
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: In recent decades, large-scale English language proficiency testing and testing research have seen an increased interest in constructed-response essay-writing items (Aschbacher, 1991; Powers, Burstein, Chodorow, Fowles, & Kukich, 2001; Weigle, 2002). The TOEFL iBT, for example, includes two constructed-response writing tasks, one of which is an integrative task requiring the test-taker to write in response to information delivered both aurally and in written form (Educational Testing Service, n.d.). Similarly, the IELTS academic test requires test-takers to write in response to a question that relates to a chart or graph that the test-taker must read and interpret (International English Language Testing System, n.d.). Theoretical justification for the use of such integrative, constructed-response tasks (i.e., tasks which require the test-taker to draw upon information received through several modalities in support of a communicative function) date back to at least the early 1960’s.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Measuring dark energy spatial inhomogeneity with supernova data
Creators: name: Cooray, Asantha
name: Holz, Daniel E.
name: Caldwell, Robert
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The gravitational lensing distortion of distant sources by the large-scale distribution of matter in the Universe has been extensively studied. In contrast, very little is known about the effects due to the large-scale distribution of dark energy. We discuss the use of Type Ia supernovae as probes of the spatial inhomogeneity and anisotropy of dark energy. We show that a shallow, almost all-sky survey can limit rms dark energy fluctuations at the horizon scale down to a fractional energy density of ~10^-4
description: 4 pages; PRL submitted
Impact of reimbursement restriction on drug market sales under the national health insurance in Japan
Creators: name: Mamiya, Hiroaki
name: Igarashi, Ataru
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: National health care expenditures have been increasing each year, although the Japanese government has annually revised official drug prices. Managing the health care system to pay for expensive drugs is a major concern. The reimbursement restriction, which is the only way that a drug can be implemented prior to market entry in Japan, is crucial for managing expenditures. Therefore, this study identifies the impact of the reimbursement restriction on drug market sales in Japan, particularly in the situation where health technology assessment or other market access regulations are not applicable before market entry. All new drugs listed in fiscal years 2011 to 2019, along with their market size forecast, were identified using the materials from the Central Social Insurance Medical Council. We then calculated the percentage rate of reimbursement amounts based on the National Database of Health Insurance Claims relative to the predicted market size as a dependent variable. Using the reimbursement restriction for each drug as an independent variable, we performed descriptive and univariate analyses on each variable, followed by generalized linear mixed-effects model regression analysis. We identified 211 drugs. The mean rates of drugs that required physicians, facilities, and patients to meet criteria for use were 30.85% (n = 2), 31.42% (n = 2), and 72.11% (n = 6), respectively. The mean rate of drugs that required diagnostic testing was 22.99% (n = 7), which was 3.7 times lower than the rate of drugs that did not require such testing (p Our results indicate that the reimbursement restriction requiring diagnostic testing has a substantial impact on decreasing market sales. As the number of cases for each requirement is small, further study is needed to measure the impact of the other reimbursement restrictions.
The neurotechnology patent landscape in a time of neuroethics : 2016-2020
Creators: name: Rotenberg, Ari
Publisher: name: University of British Columbia
Year: 2023

description: Over the past decades, invasive and non-invasive neuromodulation approaches have emerged to manage neurologic and psychiatric conditions, along with powerful functional neuroimaging methods that provide insights to the physiologic bases for cognition and behavior. However, new capabilities realized by neurotechnology also introduce new concerns. Neurotechnology has proliferated into industries such as defense, advertising, and retail, evolving in ways that may impinge on the privacy of thought and create injustices in human performance. In these contexts, newfound access to the brain raises broad concerns for human rights. In this thesis, I examine 779 patents granted by the USPTO between 2016 and 2020 as a publicly accessible record of inventions early in commercial development to understand the characteristics of neurotechnology innovation and assess their ethical and social implications. By applying qualitative methods to existing patent infrastructure, I develop a perspective of an innovation landscape rooted strongly in healthcare. Neuromodulation is most prominent, with conditions affecting the injured or aging brain a substantial focus. Neurotechnology across other industries such as entertainment and finance raise concerns about consent and coercion. I further consider how these inventions may support or impede the mental protections proposed by neurorights advocates. With some concerns identified in past work and in this thesis, anticipating that more ethically fraught innovation may come down the commercial pipeline is a critical exercise. Such a practice is also fundamental to the anticipatory tenet of neuroethics. To this end, I conclude by welcoming patent experts into the neuroethics circle, and at the same time urge ongoing attention to the patent landscape as a means of informing outreach and ensuring long term societal benefits.
DMPP-3: confirmation of short-period S-type planet(s) in a compact eccentric binary star system, and warnings about long-period RV planet detections
Creators: name: Stevenson, Adam T.
name: Haswell, Carole A.
name: Barnes, John R.
name: Barstow, Joanna K.
name: Ross, Zachary O. B.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present additional HARPS radial velocity observations of the highly eccentric ($e \sim 0.6$) binary system DMPP-3AB, which comprises a K0V primary and a low-mass companion at the hydrogen burning limit. The binary has a $507$ d orbital period and a $1.2$ au semi-major axis. The primary component harbours a known $2.2$ M$_{\oplus}$ planet, DMPP-3A b, with a $6.67$ day orbit. New HARPS measurements constrain periastron passage for the binary orbit and add further integrity to previously derived solutions for both companion and planet orbits. Gaia astrometry independently confirms the binary orbit, and establishes the inclination of the binary is $63.89 \pm 0.78 ^{\circ}$. We performed dynamical simulations which establish that the previously identified $\sim800$ d RV signal cannot be attributed to an orbiting body. The additional observations, a deviation from strict periodicity, and our new analyses of activity indicators suggest the $\sim800$ d signal is caused by stellar activity. We conclude that there may be long period planet 'detections' in other systems which are similar misinterpreted stellar activity artefacts. Without the unusual eccentric binary companion to the planet-hosting star we could have accepted the $\sim800$ d signal as a probable planet. Further monitoring of DMPP-3 will reveal which signatures can be used to most efficiently identify these imposters. We also report a threshold detection (0.2 per cent FAP) of a $\sim2.26$ d periodicity in the RVs, potentially attributed to an Earth-mass S-type planet interior to DMPP-3A b.
description: 20 pages, 15 figures. Accepted for publication in MNRAS
Jokes and the Linguistic Mind
Creators: name: Roberts, Elaine
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: It is often said that understanding humor in a language is the highest sign of fluency. Comprehending de dicto jokes, specifically, demonstrates our tacit knowledge of and competence in that language. In Aarons’s Jokes and the Linguistic Mind, multitudinous examples of humor are examined in regard to the wide range of linguistic concepts they address. The text is based on Chomsky’s (1965) definition of competence as our implicit knowledge of the rules of language; it aims to show that when, for example, a joke about the ambiguity of a certain article is funny, it is precisely because it brings a rule governing article use to our consciousness. Aarons’ detailed analyses of jokes play on semantic, phonologic, pragmatic, and syntactic rules, and are therefore of interest to the linguist. At the same time, her analyses are of equal importance to the language teacher, considering that many of these rules and explanations are of pedagogical use.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Ensuring Effective Second Language Learning via CALL
Creators: name: Sun, Yayun Anny
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Bhatia and Ritchie (2009), in their book chapter, present a very promising outlook of computer-assisted language learning (CALL) and computer-assisted second language acquisition research (CASLAR). As CALL becomes an unstoppable trend in the field of education, there exist certain issues that remain to be addressed in order to maximize its potential and avoid rendering the application mere peripheral or gimmicky.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
The complexity of the Specht modules corresponding to hook partitions
Creators: name: Lim, Kay Jin
Publisher: name: arXiv
Year: 2009
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 20C30

description: Let w be the p-weight of a hook partition μand E be an elementary abelian p-subgroup generated by w disjoint p-cycles. We compute the generic Jordan type of the Specht module corresponding to the partition μrestricted to E. In particular, we show that the complexity of the Specht module is precisely the p-weight of the partition μ.
The Use of Technology In-and-Outside of Second Language Classrooms: The Need for Teacher Training in Technology
Creators: name: Park, Mi Sun
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Research has shown that the use of technology can be a pioneering and innovative means of language learning and teaching. Computer-assisted language learning (CALL) provides learners with individualized instruction, naturalistic linguistic environment, and greater opportunities to actively engage in interaction with peers and teachers A number of studies (see Bhatia & Ritchie, 2009 for more details) have reported that students in the CALL setting tend to show less negative affect but higher levels of interest, motivation, and participation in learning the target language. However, such encouraging findings were observed primarily with students who had positive attitudes toward technology, as pointed out by Bhatia and Ritchie (2009). This highlights the fact that the application of technology to language learning and/or teaching settings must be preceded by proper user education or training in materials and technology tools. In other words, both students and teachers need to be given sufficient opportunities to practice and become familiar with the technology in use in the first place; the absence of these prerequisites can render any argument for the effectiveness of CALL insufficient.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Der Einsatz gestufter Lernhilfen als Unterstützung für Lernende im Kontext des biologischen Experimentierens
Creators: name: Kleinert, Svea Isabel
name: Besa, Kris-Stephen
name: Wilde, Matthias
Publisher: name: Zeitschrift für Didaktik der Biologie (ZDB) - Biologie Lehren und Lernen
Year: 2022

description: Experimentieren im Biologieunterricht als komplexer Problemlöseprozess könnte durch den Einsatz gestufter Lernhilfen gefördert werden. Aus lernpsychologischer Sicht unterstützen diese binnendifferenzierenden und selbstständigkeitsfördernden Instrumente die Kompetenzwahrnehmung von Schüler*innen. Gleichzeitig könnte dem Motivations- und Interessenabfall in den Naturwissenschaften begegnet werden. Vor dem Hintergrund fehlender mathematischer Kompetenzen bei der Auswertung eines Experimentes könnten zusätzliche gestufte Lernhilfen im Mathematikunterricht implementiert werden. Diese instruktionalen Unterstützungen könnten gleichzeitig einen positiven Einfluss auf die wahrgenommene Kompetenz und die intrinsische Motivation der Lernenden entfalten. Die vorliegende Studie untersuchte daher den Einfluss gestufter Lernhilfen während der Auswertung eines Experimentes im Biologieunterricht sowie im Rahmen einer Unterrichtseinheit zum Thema Lineare Funktionen im Mathematikunterricht auf die Kompetenzwahrnehmung und die intrinsische Motivation der Schüler*innen. Hierzu wurden 75 Lernende einer Versuchsschule (55,2 % weiblich; MAlter = 16.5 Jahre, SDAlter = 0.80 Jahre) in einer Unterrichtseinheit zum Thema Osmose im Naturwissenschaftsunterricht sowie zum Thema Lineare Funktionen im Fach Mathematik unterrichtet und Daten zur Kompetenzwahrnehmung und weitere Daten zur intrinsischen Motivation erhoben. Mithilfe von univariaten Kovarianzanalysen wurden für den Naturwissenschafts- und Mathematikunterricht deutliche deskriptive bzw. signifikante Unterschiede in der wahrgenommenen Kompetenz, zugunsten der Lernenden, die beim biologischen Experimentieren gestufte Lernhilfen nutzten, gefunden; tendenziell signifikante Unterschiede in der intrinsischen Motivation konnten nur für das biologische Experimentieren berichtet werden. Der zusätzliche Einsatz gestufter Lernhilfen im Mathematikunterricht konnte keine Hinweise auf eine erhöhte Motivation der Lernenden hervorbringen.
description: Zeitschrift für Didaktik der Biologie (ZDB) - Biologie Lehren und Lernen, Bd. 26 (2022)
Technology’s Impact on SLA: A Response to Bhatia and Ritchie (2009)
Creators: name: Miller, Andrew
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Bhatia and Ritchie (2009) focus on the positive impact of technology, specifically “the potential and promise of technology in shaping and reshaping the direction of research on SLA and in providing a potential testing ground for current theories of SLA” (p. 545). Their enthusiastic assessment, subsequently elaborated from the perspectives of users and researchers, seems intuitively relevant in this age. Nevertheless, it is important to acknowledge technology’s limitations in language education. For example, Bhatia and Ritchie (2009) accurately observe that the emergence of technology is responsible for “the democratization of language teaching” (p. 547) to the degree that it facilitates exposure both to less commonly taught languages (LCTLs) and to almost never taught languages (ANTLs). This democratization emerges as problematic for researchers in that it generates a level of participant assimilation within a technology-driven learning space that tends to obscure not only important inter-learner differences, but also the differential effects on acquisition of technology.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
Extremely high velocity gas from the massive YSOs in IRAS 17233-3606
Creators: name: Leurini, S.
name: Codella, C.
name: Zapata, L. A.
name: Belloche, A.
name: Stanke, T.
name: Wyrowski, F.
name: Schilke, P.
name: Menten, K. M.
name: Guesten, R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Molecular outflows from high-mass young stellar objects provide an excellent way to study the star formation process, and investigate if they are scaled-up versions of their low-mass counterparts. We selected the nearby massive star forming region IRAS 17233-3606 in order to study the kinematics and physics along the molecular outflow(s) originating from this source. We observed IRAS 17233-3606 in CO, a typical tracer of gas associated with molecular outflow, with the Submillimeter Array in the (2-1) transition, and with the APEX telescope in the higher excitation (6-5) line. Additional infrared H2 observations were performed with the UKIRT telescope. The CO data were analysed using a LVG approach. Our data resolve the previously detected molecular outflow in at least three different components, one of them with a high collimation factor ~4, and characterised by emission at extremely high velocities (|v-v_{LSR}|>120 km s^{-1}). The estimate of the kinematical outflow parameters are typical of massive YSOs, and in agreement with the measured bolometric luminosity of the source. The kinematic ages of the flows are in the range 10^2-10^3 yr, and therefore point to young objects that still did not reach the main sequence.
description: accepted for publication in A&A
Computer-Assisted Second Language Teaching, Learning, and Research
Creators: name: Qi, Shaoyan
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Bhatia and Ritchie’s (2009) book chapter provided preliminary answers to the following questions: (1) In what way(s) has computer technologies impacted second language (L2) teaching and learning inside and outside of classroom? (2) In what way(s) has computer technologies shaped the field of second language acquisition (SLA)?
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)
High-power-charging: Integrationsstrategien für Niederspannungsnetze
Creators: name: Schwarz, Tim Matthias
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: 360

description: High Power Charging kann einen wesentlichen Beitrag zur Bereitstellung einer leistungsfähi-gen öffentlichen Ladeinfrastruktur leisten. Gegenwärtig ist High Power Charging überwie-gend an Verkehrsachsen – angeschlossen an die Mittelspannungsebene – vorzufinden. Im Niederspannungsnetz hingegen ist der Betrieb von High Power Charging aufgrund geringer Netzkapazitäten jedoch herausfordernd. Das Ziel dieser Arbeit ist daher die Ausfertigung einer Strategie zur Integration von High Power Charging in das Niederspannungsnetz. Zu diesem Zweck wird ein urbanes Verteilnetz in MatPower modelliert. High Power Charging-Infrastruktur und ein Batteriespeicher werden mittels Zeitreihen und dynamischer Modelle simuliert. Durch Lastflussrechnungen werden die Potentiale und Netzauswirkungen von High Power Charging im Niederspannungsnetz identifiziert. Anschließend wird ein Batterie-speicher zur Bereitstellung von Energie an die High Power Charging Infrastruktur dimensio-niert. Die Simulationsergebnisse zeigen, dass High Power Charging grundsätzlich in das Nie-derspannungsnetz integriert werden kann, dabei an transformatorfernen Standorten jedoch ein Batteriespeicher installiert werden sollte. Weiterhin wird dessen Eignung zum Ausgleich von dezentraler Erzeugung geprüft. Das Ausgleichspotential für dezentrale Erzeugung vari-iert mit den Anwendungsfällen von High Power Charging und der Jahreszeit. Photovoltaik kann wiederum Deckung der HPC-Nachfrage effektiv unterstützen.
description: High Power Charging can make a significant contribution to the provision of efficient public charging infrastructure. Currently, High Power Charging is mainly found on transport axes - connected to the medium voltage level. In the low-voltage grid, however, the operation of High Power Charging is challenging due to low grid capacities. The aim of this work is there-fore to develop a strategy for the integration of high power charging into the low voltage grid. For this purpose, an urban distribution network is modelled in MatPower. High Power Charging infrastructure and a battery storage system are simulated using time series and dynamic models. Load flow calculations are used to identify the potentials and grid effects of high power charging in the low-voltage grid. Subsequently, a battery storage system is di-mensioned to provide energy to the high power charging infrastructure. The simulation re-sults show that high power charging can in principle be integrated into the low-voltage grid, but that a battery storage system should be installed at locations remote from the trans-former. Furthermore, its suitability for balancing decentralised generation is examined. The balancing potential for decentralised generation varies with the applications of high power charging and the time of year. Photovoltaics can in turn effectively support HPC demand response.
Extended Implications of Technology in Second Language Teaching and Learning
Creators: name: Chen, Cheng-Ling Alice
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2011

description: Bhatia and Ritchie’s (2009) book chapter provides an extensive review of the core issues pertaining to second language (L2) acquisition in the information age. It also reiterates the influence of information technology on second language education. Technology, with all its merits, has “brought about a new generation of information and language learning tools” (p. 547). This is so be it used online or offline, inside or outside of the classroom, synchronously or asynchronously.
description: Studies in Applied Linguistics and TESOL, Vol. 11 No. 2 (2011)