title: Beyond the Surface: Statistical Approaches to Internal Anatomy Prediction
Creators: name: Keller, Marilyn Justine
Publisher: name: Universität Tübingen
Year: 2025
Subjects: subject: Knochen , Skelett , Anatomie , Deep learning , Maschinelles Sehen
subject: 004
subject: 3D morphable models
subject: statistical shape models

description: The creation of personalized anatomical digital twins is important in the fields of medicine, computer graphics, sports science, and biomechanics. But to observe a subject's anatomy, expensive medical devices (MRI or CT) are required and creating a digital model is often time-consuming and involves manual effort. Instead, we can leverage the fact that the shape of the body surface is correlated with the internal anatomy; indeed, the external body shape is related to the bone lengths, the angle of skeletal articulation, and the thickness of various soft tissues. In this thesis, we leverage the correlation between body shape and anatomy and aim to infer the internal anatomy solely from the external appearance. Learning this correlation requires paired observations of people's body shape, and their internal anatomy, which raises three challenges. First, building such datasets requires specific capture modalities. Second, these data must be annotated, i.e. the body shape and anatomical structures must be identified and segmented, which is often a tedious manual task requiring expertise. Third, to learn a model able to capture the correlation between body shape and internal anatomy, the data of people with various shapes and poses has to be put into correspondence. In this thesis, we cover three works that focus on learning this correlation. We show that we can infer the skeleton geometry, the bone location inside the body, and the soft tissue location solely from the external body shape. First, in the OSSO project, we leverage 2D medical scans to construct a paired dataset of 3D body shapes and corresponding 3D skeleton shapes. This dataset allows us to learn the correlation between body and skeleton shapes, enabling the inference of a custom skeleton based on an individual's body. However, since this learning process is based on static views of subjects in specific poses, we cannot evaluate the accuracy of skeleton inference in different poses. To predict the bone orientation within the body in various poses, we need dynamic data. To track bones inside the body in motion, we can leverage methods from the biomechanics field. So in the second work, instead of medical imaging, we use a biomechanical skeletal model along with simulation to build a paired dataset of bodies in motion and their corresponding skeletons. In this work, we build such a dataset and learn SKEL, a body shape and skeleton model that includes the locations of anatomical bones from any body shape and in any pose. After dealing with the skeletal structure, we broaden our focus to include different layers of soft tissues. In the third work, HIT, we leverage segmented medical data to learn to predict the distribution of adipose tissues (fat) and lean tissues (muscle, organs, \etc) inside the body. In conclusion, in this thesis we leverage statistical models and multi-modal data to learn to predict from external body shape: the geometry of the bones, their location and orientation inside the body, as well as the soft tissue distribution inside the body.