cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis, characterization, anticancer activity and molecular docking of metal complexes bearing a new Schiff base ligand
Creators: name: Alorini, Thamer
name: Al-Hakimi, Ahmed N.
name: Daoud, Ismail
name: Alminderej, Fahad
name: Albadri, Abuzar E. A. E.
name: Aroua, Lotfi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: 2-((E)-((4-(((E)-4-Nitrobenzylidene)amino)phenyl)imino)methyl)naphthalen-1-ol, was synthesised followed by metalation with Fe(III), Co(III), Cu(II), Zn(II) and Ni(II) metals. The compounds were characterised by different methods CHN, AAS, IR, NMR, XRD, TGA and UV–Vis. The results reveal that the ligand has bidentate behavior, and it is bound with metals by a coordination bond through both the nitrogen atom of the azomethine group and the oxygen atom, this provided an octahedral geometry. The X-ray diffraction of the compounds indicate that the ligands and complexes of Co(III), Fe(III) and Zn(II) have a crystalline nature, whereas the Ni(II) and Cu(II) have an amorphous structure. The agar diffusion method (hole plate) was used to evaluate the ligand’s and its complexes’ antibacterial and antifungal effects on Salmonella enterica serovar typhi and Candida albicans, respectively. It was observed that the Fe(III) complex had the best activity among the compounds against microbial strains. Cytotoxicity of new metal complexes was also assessed against A549, HepG-2 and PC-3 cancer cells. Results demonstrated that the Cu(II) complex displayed the preeminent activity among the synthesised compounds against all the tested cell lines. Furthermore, molecular docking simulation revealed that the Fe(III) complex is shown to have a high affinity with the active sites of two targets of microbial strains. Also, the Cu(II) complex shown to has a high affinity with the active sites of three targets of A-549, HepG-2 and PC-3 cancer cells, which was confirmed by the formation of the different modes of interaction. Communicated by Ramaswamy H. Sarma
Critical Behaviour of the Fuzzy Sphere
Creators: name: O'Connor, Denjoe
name: Dolan, Brian P.
name: Vachovski, Martin
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study a multi-matrix model whose low temperature phase is a fuzzy sphere that undergoes an evaporation transition as the temperature is increased. We investigate finite size scaling of the system as the limiting temperature of stability of the fuzzy sphere phase is approached. We find on theoretical grounds that the system should obey scaling with specific heat exponent α=1/2, shift exponent \bar λ=4/3 and that the peak in the specific heat grows with exponent \bar ω=2/3. Using hybrid Monte Carlo simulations we find good collapse of specific heat data consistent with a scaling ansatz which give our best estimates for the scaling exponents as α=0.50 \pm 0.01,\bar λ=1.41 \pm 0.08 and \bar ω=0.66 \pm 0.08 .
description: 30 pages, 10 figures
Modulation of sensory information processing by a neuroglobin in C. elegans
Creators: name: Oda, Shigekazu
name: Toyoshima, Yu
name: de Bono, Mario
Publisher: name: arXiv
Year: 2016
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. We show that in the C. elegans URX O2 sensing neurons two putative molecular O2 sensors, a neuroglobin and O2-binding soluble guanylate cyclases, work antagonistically to sculpt a slowly sigmoidal O2 response curve tuned to approach saturation when O2 reaches 21%. glb-5 imposes this sigmoidal function by inhibiting O2-evoked Ca2+ responses in URX when O2 levels fall. Without GLB-5, the URX response curve approaches saturation at 15% O2. Behaviorally, GLB-5 signaling broadens the O2 preference of C. elegans while maintaining strong avoidance of 21% O2. Our computational aerotaxis model suggests that the relationship between GLB-5-modulated URX responses and reversal behavior is sufficient to broaden O2-preference. Thus, a neuroglobin can shift neural information coding leading to a change in perception and altered behavior.
description: 29 page, 5 figures, 11 supplementary figures
Comment on "Non-representative Quantum Mechanical Weak Values"
Creators: name: Israel, Alon Ben
name: Vaidman, L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Svensson [Found. Phys. 45, 1645 (2015)] argued that the concept of the weak value of an observable of a pre- and post-selected quantum system cannot be applied when the expectation value of the observable in the initial state vanishes. Svensson's argument is analyzed and shown to be inconsistent using several examples.
description: 2 pages, comment on Found. Phys. 45, 1645 (2015)
Lattice equations arising from discrete Painlevé systems (I): $(A_2+A_1)^{(1)}$ and $(A_1+A_1')^{(1)}$ cases
Creators: name: Joshi, Nalini
name: Nakazono, Nobutaka
name: Shi, Yang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We introduce the concept of $ω$-lattice, constructed from $τ$ functions of Painlevé systems, on which quad-equations of ABS type appear. In particular, we consider the $A_5^{(1)}$- and $A_6^{(1)}$-surface $q$-Painlevé systems corresponding affine Weyl group symmetries are of $(A_2+A_1)^{(1)}$- and $(A_1+A_1)^{(1)}$-types, respectively.
description: 27 pages, 9 figure
Sylvisorex Thomas 1904
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex

description: Sylvisorex Thomas, 1904. Abstr. Proc. Zool. Soc. Lond., 10: 12. COMMENT: This genus has been regarded as part of Suncus by Smithers and Tello, 1976, Mus. Mem. Salisbury, 8: 1-184, but was retained by Ansell, 1978:13. Subfamily Crocidurinae; see Repenning, 1967:15. ISIS NUMBER: 5301403007022000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 101, DOI: 10.5281/zenodo.7353001
description: {"references": ["Smithers, R. H. N., and J. L. P. Lobao Tello. 1976. Check list and atlas of the mammals of Mozambique. Museum Memoir, National Museums and Monuments of Rhodesia, Salisbury, 8: 1 - 184.", "Ansell, W. F. H. 1978. The mammals of Zambia. National Parks and Wildlife Service, Chilanga, 126 pp.", "Repenning, C. A. 1967. Subfamilies and genera of the Soricidae. Geological Survey Professional Paper, 565: 1 - 74."]}
Perturbative series and the 1/N expansion for the QED β-function
Creators: name: Larin, S. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A comparison of the perturbative series and the 1/N expansion for the QED renormalization group β-function in the Minimal Subtraction scheme is performed. The good agreement between two expansions is found which proves that the MS β-function is under perfect perturbative control.
description: 4 pages
A mean-field monomer-dimer model with attractive interaction. The exact solution
Creators: name: Alberici, Diego
name: Contucci, Pierluigi
name: Mingione, Emanuele
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 82B20

description: A mean-field monomer-dimer model which includes an attractive interaction among both monomers and dimers is introduced and its exact solution rigorously derived. The Heilmann-Lieb method for the pure hard-core interacting case is used to compute upper and lower bounds for the pressure. The bounds are shown to coincide in the thermodynamic limit for a suitable choice of the monomer density m. The consistency equation characterising m is studied in the phase space (h, J), where h tunes the monomer potential and J the attractive potential. The critical point and exponents are computed and show that the model is in the mean-field ferromagnetic universality class.
description: 32 pages, 6 figures
Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species
Creators: name: Dmitrieff, Serge
name: Alsina, Adolfo
name: Mathur, Aastha
name: Nédélec, François
Publisher: name: arXiv
Year: 2016
Subjects: subject: Subcellular Processes (q-bio.SC)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The fast blood stream of animals is associated with large shear stresses. Consequently, blood cells have evolved a special morphology and a specific internal architecture allowing them to maintain their integrity over several weeks. For instance, non-mammalian red blood cells, mammalian erythroblasts and platelets have a peripheral ring of microtubules, called the marginal band, that flattens the overall cell morphology by pushing on the cell cortex. In this article, we model how the shape of these cells stems from the balance between marginal band elasticity and cortical tension. We predict that the diameter of the cell scales with the total microtubule polymer, and verify the predicted law across a wide range of species. Our analysis also shows that the combination of the marginal band rigidity and cortical tension increases the ability of the cell to withstand forces without deformation. Finally, we model the marginal band coiling that occurs during the disc-to-sphere transition observed for instance at the onset of blood platelet activation. We show that when cortical tension increases faster than crosslinkers can unbind, the marginal band will coil, whereas if the tension increases slower, the marginal band may shorten as microtubules slide relative to each other.
MPEC 2025-C70 : 2021 UT11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Sylvisorex granti Thomas 1907
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex granti

description: Sylvisorex granti Thomas, 1907. Ann. Mag. Nat. Hist., ser. 7, 19: 118. TYPE LOCALITY: Uganda, Ruwenzori East, Mubuku Valley, 10,000 ft. (3048 m). DISTRIBUTION: Cameroun; Uganda; Rwanda; E. Zaire; Kenya; Tanzania. COMMENT: Includes camerounensis and inundus; see Heim de Balsac and Meester, 1977, Part 1:8. ISIS NUMBER: 5301403007022001001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 101, DOI: 10.5281/zenodo.7353001
description: {"references": ["Heim de Balsac, H., and J. Meester. 1977. Order Insectivora. Part 1. Pp. 1 - 29, in The mammals of Africa: An identification manual (J. Meester and H. W. Setzer, eds.). [issued 22 Aug 1977]. Smithsonian Institution Press, Washington, D. C., not continuously paginated."]}
title: Angelus Custos. Schutzengel; 1620
title: Das ist Sum[m]arischer Inhalt der Comoediae von dem Schutz vnd Gutthaten der lieben heiligen Engeln, gegen den Menschen. Gehalten Als der Hochwürdige Fürst vnd Herr, Herr Johann Christoff Bischoff zu Eystett [et]c. die von Seiner Fürstl. Gn. der Societet Jesu, alda New stattlich erbawte vnd gezierte Kirchen, Gott dem Allmächtigen zu Ehren vnd Gedächtnuß aller H. Englen selbst geweyhet hat. Von dem Gymnasio Societatis Jesv daselbst, den 31. Tag Augusti 1620
titleType: Subtitle
Creators: name: Baumann, Christian
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012

description: Perioche
Rotational bands in the continuum illustrated by $^{8}$Be results
Creators: name: Garrido, E.
name: Jensen, A. S.
name: Fedorov, D. V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We use the two-alpha cluster model to describe the properties of $^{8}$Be. The rotational energy sequence of the $(0^+,2^+,4^+)$ resonances are reproduced with the complex energy scaling technique for Ali-Bodmer and Buck-potentials. However, both static and transition probabilities are far from the rotational values. We trace this observation to the prominent continuum properties of the $2^+$ and $4^+$ resonances. They resemble free continuum solutions although still exhibiting strong collective rotational character. We compare with cluster models and discuss concepts of rotations in the continuum in connection with central quantities as transition probabilities, inelastic cross sections and resonance widths. We compute the $6^+$ and $8^+$ $S$-matrix poles and discuss properties of this possible continuation of the band beyond the known $4^+$ state. Regularization of diverging quantities are discussed in order to extract observable continuum properties. We formulate division of electromagnetic transition probabilities into interfering contributions from resonance-resonance, continuum-resonance, resonance-continuum, and continuum-continuum transitions.
description: To be published in Physical Review C
Sappanin-type homoisoflavonoids from Scilla nervosa inhibits acetylcholinesterase enzyme: a combined in silico and in vitro approach
Creators: name: Famuyiwa, Samson O.
name: Patil, Rajesh B.
name: Faloye, Kolade O.
name: Awotuya, Iyanu O.
name: Gadhawe, Sandeep P.
name: Oladiran, Oluyemi J.
name: Bello, Oyenike I.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Alzheimer’s disease is among the major health challenges that currently attract the attention of health care givers and drug discovery and development experts worldwide. This study investigated the acetylcholinesterase inhibitory activity of sappanin-type homisoflavonoids isolated from the inter-bulb surface of Scilla nervosa. Molecular docking, molecular dynamics simulation, ADMET and in vitro studies were performed to identify the hit molecules, understand their binding mode and interaction, druggability and establish their inhibitory potentials against acetylcholinesterase enzyme. The hit compounds 5, 2, 1 and 4 were identified as the hit molecules through the molecular docking. The molecular dynamics simulation and MM-PBSA analysis showed the hit homoisoflavonoids established stability and good binding affinity against the acetylcholinesterase enzyme. Also, 5 elicited the best inhibitory activity followed by 2, 1 and 4 in the in vitro experiment. Furthermore, the selected homoisoflavonoids exhibit interesting drug likeness and pharmacokinetic properties as drug candidate. The results suggest further investigations towards the development of the phytochemicals as possible acetylcholinesterase inhibitors. Communicated by Ramaswamy H. Sarma
A mechano-chemical feedback underlies co-existence of qualitatively distinct cell polarity patterns within diverse cell populations
Creators: name: Park, JinSeok
name: Holmes, William R.
name: Lee, Sung-Hoon
name: Kim, Hong-Nam
name: Kim, Deok-Ho
name: Kwak, Moon Kyu
name: Wang, Chiaochun Joanne
name: Suh, Kahp-Yang
name: Edelstein-Keshet, Leah
name: Levchenko, Andre
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cell Behavior (q-bio.CB)
subject: FOS: Biological sciences

description: Cell polarization and directional cell migration can display random, persistent and oscillatory dynamic patterns. However, it is not clear if these polarity patterns can be explained by the same underlying regulatory mechanism. Here, we show that random, persistent and oscillatory migration accompanied by polarization can simultaneously occur in populations of melanoma cells derived from tumors with different degrees of aggressiveness. We demonstrate that all these patterns and the probabilities of their occurrence are quantitatively accounted for by a simple mechanism involving a spatially distributed, mechano-chemical feedback coupling the dynamically changing extracellular matrix (ECM)-cell contacts to the activation of signaling downstream of the Rho-family small GTPases. This mechanism is supported by a predictive mathematical model and extensive experimental validation, and can explain previously reported results for diverse cell types. In melanoma, this mechanism also accounts for the effects of genetic and environmental perturbations, including mutations linked to invasive cell spread. The resulting mechanistic understanding of cell polarity quantitatively captures the relationship between population variability and phenotypic plasticity, with the potential to account for a wide variety of cell migration states in diverse pathological and physiological conditions.
One enzyme, many faces: urease is also canatoxin
Creators: name: Moro, Carlo Frederico
name: Nogueira, Fábio C. S.
name: Almeida, Carlos Gabriel Moreira
name: Real-Guerra, Rafael
name: Dalberto, Pedro Ferrari
name: Bizarro, Cristiano V.
name: Ligabue-Braun, Rodrigo
name: Carlini, Celia R.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Ureases catalyze the hydrolysis of urea into carbamate and ammonia. Well-conserved proteins, most plant ureases are hexamers of a single chain subunit, like the most abundant isoform of the jack bean (Canavalia ensiformis) urease (JBU). Canatoxin (CNTX) was originally isolated from these seeds as a neurotoxic protein, and later characterized as an isoform of JBU with lower molecular mass and enzyme activity. Inactive CNTX oligomers form upon storage and stabilization of CNTX was achieved by treatment with low concentration of formaldehyde, avoiding its oligomerization. Here, nano-LC-MS/MS-based peptide analysis of CNTX revealed 804 amino acids identical to those of JBU’s sequence (840 amino acids). De novo sequencing of CNTX revealed 15 different peptides containing substitution of amino acid residues, denoting CNTX as a product of a paralog gene of JBU. The MS/MS analysis of formaldehyde-treated CNTX showed that amino acid residues located at the trimer–trimer interface of JBU’s hexamer were modified. The data confirmed that CNTX is an isoform of JBU and elucidated that stabilization by formaldehyde treatment occurs by modification of amino acids at the protein’s surface that prevents the formation of the hexamer and of higher molecular mass inactive aggregates. HIGHLIGHTSCanatoxin (CNTX) is an isoform of jack bean urease (JBU, hexamer of 90 kDa chains)MS/MS sequencing of CNTX showed 804 amino acids identical in JBU (840 residues)Formaldehyde treatment of CNTX stabilizes its toxicity and avoids oligomerizationModified amino acid residues in CNTX are at the trimer–trimer interface of JBU Canatoxin (CNTX) is an isoform of jack bean urease (JBU, hexamer of 90 kDa chains) MS/MS sequencing of CNTX showed 804 amino acids identical in JBU (840 residues) Formaldehyde treatment of CNTX stabilizes its toxicity and avoids oligomerization Modified amino acid residues in CNTX are at the trimer–trimer interface of JBU Communicated by Ramaswamy H. Sarma
Improved Equation of State for Finite-Temperature Spin-Polarized Electron Liquids on the Basis of Singwi-Tosi-Land-Sjolander Approximation
Creators: name: Tanaka, Shigenori
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: An accurate expression for the exchange-correlation free energy f_{xc} of homogeneous electron fluids at finite temperatures is presented on the basis of Singwi-Tosi-Land-Sjolander (STLS) approximation. In addition to the derivation for the paramagnetic state, that for the ferromagnetic state is newly carried out in which a correction in the strong Coulomb coupling regime is incorporated into the construction of analytic expression as a function of the coupling constant and the Fermi degeneracy. The fitting formula for f_{xc} is then extended over any degree of spin polarization with the aid of available interpolation scheme. The proposed equation of state, called iSTLS formula, shows reasonable agreements with the existing quantum Monte Carlo evaluations at finite temperatures in the paramagnetic state, thus giving a consensus for the thermodynamic functions between many-body theories and computer simulations. On the other hand, the current status for the agreement among various evaluations of f_{xc} is relatively unsatisfactory in the ferromagnetic state, suggesting the necessity of further investigations.
description: 19 page manuscript, 13 figures, and Supplemental Material; Submitted to Contrib. Plasma Phys
Sylvisorex johnstoni
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex johnstoni

description: Sylvisorex johnstoni (Dobson, 1888). Proc. Zool. Soc. Lond., 1887:577. TYPE LOCALITY: Cameroun, Rio del Rey. DISTRIBUTION: S.W. Cameroun; Gabon; Boiko; Zaire. ISIS NUMBER: 5301403007022002001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 101, DOI: 10.5281/zenodo.7353001
The enclosure method for inverse obstacle scattering using a single electromagnetic wave in time domain
Creators: name: Ikehata, Masaru
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35R30, 35L50, 35Q61, 78A46, 78M35

description: In this paper, a time domain enclosure method for an inverse obstacle scattering problem of electromagnetic wave is introduced. The wave as a solution of Maxwell's equations is generated by an applied volumetric current having an {\it orientation} and supported outside an unknown obstacle and observed on the same support over a finite time interval. It is assumed that the obstacle is a perfect conductor. Two types of analytical formulae which employ a {\it single} observed wave and explicitly contain information about the geometry of the obstacle are given. In particular, an effect of the orientation of the current is catched in one of two formulae. Two corollaries concerning with the detection of the points on the surface of the obstacle nearest to the centre of the current support and curvatures at the points are also given.
description: Corrected proof of Lemma 2.1; improved proof of Lemma 2.2
Existence and non-existence of frequently hypercyclic subspaces for weighted shifts
Creators: name: Menet, Quentin
Publisher: name: arXiv
Year: 2013
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 47A16

description: We study the existence and the non-existence of frequently hypercyclic subspaces in Banach spaces. In particular, we give an example of a weighted shift on lp possessing a frequently hypercyclic subspace and an example of a frequently hypercyclic weighted shift on lp possessing a hypercyclic subspace but no frequently hypercyclic subspace. The latter example allows us to answer positively Problem 1 posed by Bonilla and Grosse-Erdmann in [Monatsh. Math. 168 (2012)].
description: 9 pages
Entanglement of a class of non-Gaussian states in disordered harmonic oscillator systems
Creators: name: Abdul-Rahman, Houssam
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: For disordered harmonic oscillator systems over the $d$-dimensional lattice, we consider the problem of finding the bipartite entanglement of the uniform ensemble of the energy eigenstates associated with a particular number of modes. Such ensemble define a class of mixed, non-Gaussian entangled states that are labeled, by the energy of the system, in an increasing order. We develop a novel approach to find the exact logarithmic negativity of this class of states. We also prove entanglement bounds and demonstrate that the low energy states follow an area law.
description: 21 pages, to appear at JMP
Novel pseudonucleosides and sulfamoyl-oxazolidinone β-D-glucosamine derivative as anti-COVID-19: design, synthesis, and in silico study
Creators: name: Mansouri, Rachida
name: Bouzina, Abdeslem
name: Sekiou, Omar
name: Aouf, Zineb
name: Zerrouki, Rachida
name: Ibrahim-ouali, Malika
name: Aouf, Nour eddine
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: New pseudonucleosides containing cyclic sulfamide moiety and sulfamoyl β-D-glucosamine derivative are described. These pseudonucleosides are synthesized in good yields starting from chlorosulfonyl isocyanate and β-D-glucosamine hydrochloride in five steps; (protection, acetylation, removal of the Boc group, sulfamoylation, and cyclization). Further, novel glycosylated sulfamoyloxazolidin-2-one is prepared in three steps; carbamoylation, sulfamoylation, and intramolecular cyclization. The structures of the synthesized compounds were confirmed by usual spectroscopic and spectrometric methods NMR, IR, MS, and EA. Interesting molecular docking of the prepared pseudonucleosides and (Beclabuvir, Remdesivir) drugs with SARS-CoV-2/Mpro (PDB:5R80) was conducted using the same parameters for a fair comparison. A low binding affinity of the synthesized compounds compared to the Beclabuvir and other analysis showed that pseudonucleosides have the ability to inhibit SARS-CoV-2. After the motivating results of molecular docking study, the complex between the SARS-CoV-2 Mpro and compound 7 was subjected to 100 ns molecular dynamics (MD) simulation using Desmond module of Schrodinger suite, during which the receptor-ligand complex showed substantial stability after 10 ns of MD simulation. Also, we studied the prediction of absorption, distribution, properties of metabolism, excretion, and toxicity (ADMET) of the synthesized compounds. Communicated by Ramaswamy H. Sarma
Conjoint hepatobiliary-enterohepatic cycles for amyloid excretion and enhancing its drug-induced clearance: a systems biology approach to Alzheimer’s disease
Creators: name: Bhattacharjee, Anindita
name: Roy, Prasun K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: The liver is the major organ responsible for metabolism of amyloid-beta, the primary toxic misfolded protein responsible for Alzheimer’s disease (AD). The present study focuses on the crucial role of liver in AD. We have developed a framework that formulates and integrates two reciprocal transport processes of amyloid, via hepato-biliary and enterohepatic circulations (EHC). Our system analysis approach shows that activating the liver X-receptor (LXR) can reduce amyloid-beta formation by increasing expression of the genes: ATP-binding-cassette-transporter (ABCA1) and Stearoyl-CoA-desaturase (SCD). Besides, activating the pregnane-X-receptor (PXR) can enhance the clearance of amyloid-beta by increasing the expression of the genes: ATP-Binding-Cassette-Superfamily-G-member-2 (ABCG2) and multidrug-resistance protein-1 (MDR1). We also identified receptor-like apical sodium-dependent bile-acid transporter (ASBT) of intestinal enterocyte, showing affinity towards amyloid-beta, suggesting amyloid-beta’s possible reuptake from intestinal contents to the systemic circulation through this receptor. Further, we have performed protein-protein interaction to evaluate the binding affinity of amyloid-beta to these receptors. Moreover, we undertook molecular docking and molecular dynamic simulation of some repurposed drugs (rifampicin, 24-hydroxycholesterols, resveratrol, cilostazol) which can target the aforesaid receptors to enhance amyloid-beta’s fecal clearance, reduce amyloid-beta formation, and prevent the reuptake of amyloid-beta from intestinal feces. Additionally, network pharmacology and synergism analysis were utilized to validate our hypothesis and identify the drug combinations, respectively. Gene-ontology investigation, network pharmacology, and consolidated pathway analysis validate the alteration of the above-mentioned gene expression profiles. Furthermore, our neuropharmacological synergism study identifies the optimal combination of the repurposed drugs. Finally, our findings on candidate drugs are substantiated by clinical-trial outcomes. Communicated by Ramaswamy H. Sarma
$B\toπ\ellν$ and $B\toπ\ell^+\ell^-$ semileptonic form factors from unquenched lattice QCD
Creators: name: Du, Daping
name: Bailey, Jon A.
name: Bazavov, A.
name: Bernard, C.
name: El-Khadra, A. X.
name: Gottlieb, Steven
name: Jain, R. D.
name: Kronfeld, A. S.
name: Laiho, J.
name: Liu, Yuzhi
name: Mackenzie, P. B.
name: Meurice, Y.
name: Van de Water, R. S.
name: Zhou, Ran
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We update the lattice calculation of the $B\toπ$ semileptonic form factors, which have important applications to the CKM matrix element $|V_{ub}|$ and the $B\toπ\ell^+\ell^-$ rare decay. We use MILC asqtad ensembles with $N_f=2+1$ sea quarks and over a range of lattice spacings $a \approx 0.045$--$0.12$ fm. We perform a combined chiral and continuum extrapolation of our lattice data using SU(2) staggered chiral perturbation theory in the hard pion limit. To extend the results for the form factors to the full kinematic range, we take a functional approach to parameterize the form factors using the Bourrely-Caprini-Lellouch formalism in a model-independent way. Our analysis is still blinded with an unknown off-set factor which will be disclosed when we present the final results.
description: 7 pages, 3 figures, presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, Germany
title: Summarischer Jnnhalt der Tragedien, Von dem heiligen Martyrer vnnd Antiochenischen Bischoff Ignatio deß Collegij Conuictorum allhie Patron; 1605
title: Welcher Auß Syrien gen Rom geschickt, vnnd allda den Löwen fürgeworffen, inn dem Jar Christi CX. Anacleti deß Bapsts im IIX. Traiani deß Keysers im XI. Gehalten inn dem Academischen Gymnasio Societatis Iesv, Zu Ingolstadt, Anno M.DCV.
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012

description: Perioche
title: Summarischer Inhalt Dramatis Von[n] Asmu[n]do deß Königs auß Hetmarchien Sohn, vnd Asuico Königs auß Vichia; 1616
title: Was massen sie vnzertrennliche Freundtschafft mit einander gemacht, vnd biß inn den Todt gelaistet. Gehalten zu Ingolstadt in dem Academischen Gymnasio der Societet Iesv, den 13. Octobris Anno 1616
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012

description: Perioche
Sylvisorex lunaris Thomas 1906
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex lunaris

description: Sylvisorex lunaris Thomas, 1906. Ann. Mag. Nat. Hist., ser. 7, 18: 139. TYPE LOCALITY: Uganda, Ruwenzori East, Mubuku Valley, 12,500 ft. (3810 m). DISTRIBUTION: Medje (N.E. Zaire) to Ruwenzori East (Uganda) and Birunga Volcanoes (Kivu, Zaire). COMMENT: Includes oriundus and ruandae; see Heim de Balsac and Meester, 1977, Part 1:8. Gureev, 1979:380-381, listed oriundus and ruandae as distinct species. ISIS NUMBER: 5301403007022003001 as S. lunaris. 5301403007022006001 as S. oriundus. 5301403007020014001 as Suncus ruandae.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 101, DOI: 10.5281/zenodo.7353001
description: {"references": ["Heim de Balsac, H., and J. Meester. 1977. Order Insectivora. Part 1. Pp. 1 - 29, in The mammals of Africa: An identification manual (J. Meester and H. W. Setzer, eds.). [issued 22 Aug 1977]. Smithsonian Institution Press, Washington, D. C., not continuously paginated.", "Gureev, A. A. 1979. Fauna SSSR, Mlekopitayutschie, tom. 4, vyp. 2. Nasekomoyadnye ... [Fauna of the USSR, Mammals, vol. 4, pt. 2. Insectivores (Mammalia, Insectivora)]. Nauka, Leningrad, 501 pp. (in Russian)."]}
Master integrals for the NNLO virtual corrections to $μe$ scattering in QED: the planar graphs
Creators: name: Mastrolia, Pierpaolo
name: Passera, Massimo
name: Primo, Amedeo
name: Schubert, Ulrich
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We evaluate the master integrals for the two-loop, planar box-diagrams contributing to the elastic scattering of muons and electrons at next-to-next-to leading-order in QED. We adopt the method of differential equations and the Magnus exponential series to determine a canonical set of integrals, finally expressed as a Taylor series around four space-time dimensions, with coefficients written as combination of generalised polylogarithms. The electron is treated as massless, while we retain full dependence on the muon mass. The considered integrals are also relevant for crossing-related processes, such as di-muon production at $e^+ e^-$-colliders, as well as for the QCD corrections to $top$-pair production at hadron colliders.
description: article unchanged; updated ancillary file
Scientific progress despite irreproducibility: A seeming paradox
Creators: name: Shiffrin, Richard M.
name: Borner, Katy
name: Stigler, Stephen M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Other Statistics (stat.OT)
subject: FOS: Computer and information sciences

description: It appears paradoxical that science is producing outstanding new results and theories at a rapid rate at the same time that researchers are identifying serious problems in the practice of science that cause many reports to be irreproducible and invalid. Certainly the practice of science needs to be improved and scientists are now pursuing this goal. However, in this perspective we argue that this seeming paradox is not new, has always been part of the way science works, and likely will remain so. We first introduce the paradox. We then review a wide range of challenges that appear to make scientific success difficult. Next, we describe the factors that make science work-in the past, present, and presumably also in the future. We then suggest that remedies for the present practice of science need to be applied selectively so as not to slow progress, and illustrate with a few examples. We conclude with arguments that communication of science needs to emphasize not just problems but the enormous successes and benefits that science has brought and is now bringing to all elements of modern society.
description: 3 figures
Synthesis, characterization and docking studies of benzenesulfonamide derivatives containing 1,2,3-triazole as potential ınhibitor of carbonic anhydrase I-II enzymes
Creators: name: Güngör, Seyit Ali
name: Köse, Muhammet
name: Tümer, Mehmet
name: Türkeş, Cüneyt
name: Beydemir, Şükrü
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Carbonic Anhydrases (CAs) are an important family of metalloenzymes that contain zinc (Zn2+) ions in their active site and catalyze the conversion of carbon dioxide to bicarbonate and proton and found in all living organisms. Sulfonamides are well-known inhibitors of CAs isoenzymes. In this study, a series of benzenesulfonamide derivatives (9a–h) containing 1,2,3-triazole-moiety were designed, synthesized and their structures were characterized by spectroscopic methods. In addition, molecular structures of compounds 5a, 5 b, 9e and 9f were elucidated by X-ray diffraction technique. To investigate drug similarity of 9a–h compounds, Lipinski’s five rules (ADMET: absorption, distribution, metabolism, excretion and toxicity) were carried out by in silico studies. According to results, the compounds showed drug-like properties. Docking studies were applied to determine the scores, interactions and binding modes of compounds 9a–h against hCA I and hCA II enzymes. Compound 9c (-5.13 kcal/mol docking score) against hCA I enzyme and 9 h (-5.32 kcal/mol docking score) against hCA II enzyme showed potent inhibitory properties. The binding interactions of the compounds with the carbonic anhydrases were examined by docking studies. Communicated by Ramaswamy H. Sarma
Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot
Creators: name: Roca, Jorjethe
name: Hori, Naoto
name: Velmurugu, Yogambigai
name: Narayanan, Ranjani
name: Narayanan, Prasanth
name: Thirumalai, D.
name: Ansari, Anjum
Publisher: name: arXiv
Year: 2017
Subjects: subject: Biomolecules (q-bio.BM)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics. Therefore, it is important to elucidate the general principles governing their thermodynamics/folding mechanisms. Here, we combine experiments and simulations to examine the folding/unfolding pathways of the VPK pseudoknot, a variant of the Mouse Mammary Tumor Virus (MMTV) PK involved in ribosomal frameshifting. Fluorescent nucleotide analogs (2-aminopurine and pyrrolocytidine) placed at different stem/loop positions in the PK, and laser temperature-jump approaches serve as local probes allowing us to monitor the order of assembly of VPK with two helices with different intrinsic stabilities. The experiments and molecular simulations show that at 50 mM KCl the dominant folding pathway populates only the more stable partially folded hairpin. As the salt concentration is increased a parallel folding pathway emerges, involving the less stable hairpin structure as an alternate intermediate. Notably, the flux between the pathways is modulated by the ionic strength. The findings support the principle that the order of PK structure formation is determined by the relative stabilities of the hairpins, which can be altered by sequence variations or salt concentrations. Our study not only unambiguously demonstrates that PK folds by parallel pathways, but also establishes that quantitative description of RNA self-assembly requires a synergistic combination of experiments and simulations.
description: Supporting Information included
Contextually learnt detection of unusual motion-based behaviour in crowded public spaces
Creators: name: Arandjelović, Ognjen
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this paper we are interested in analyzing behaviour in crowded public places at the level of holistic motion. Our aim is to learn, without user input, strong scene priors or labelled data, the scope of "normal behaviour" for a particular scene and thus alert to novelty in unseen footage. The first contribution is a low-level motion model based on what we term tracklet primitives, which are scene-specific elementary motions. We propose a clustering-based algorithm for tracklet estimation from local approximations to tracks of appearance features. This is followed by two methods for motion novelty inference from tracklet primitives: (a) we describe an approach based on a non-hierarchial ensemble of Markov chains as a means of capturing behavioural characteristics at different scales, and (b) a more flexible alternative which exhibits a higher generalizing power by accounting for constraints introduced by intentionality and goal-oriented planning of human motion in a particular scene. Evaluated on a 2h long video of a busy city marketplace, both algorithms are shown to be successful at inferring unusual behaviour, the latter model achieving better performance for novelties at a larger spatial scale.
Sylvisorex megalura
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex megalura

description: Sylvisorex megalura (Jentink, 1888). Notes Leyden Mus., 10:48. TYPE LOCALITY: Liberia, Junk River, Schieffelinsville. DISTRIBUTION: Upper Guinea to Ethiopia; Angola and Kenya to W. Mozambique and E. Zimbabwe. COMMENT: Includes angolensis, gemmeus, infuscus, Irene, phaeopus, sheppardi, sorella, and sorelloides. See Heim de Balsac and Meester, 1977, Part 1:7—8. Gureev, 1979:381, listed sorella as a distinct species without comment. ISIS NUMBER: 5301403007022004001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 101, DOI: 10.5281/zenodo.7353001
description: {"references": ["Heim de Balsac, H., and J. Meester. 1977. Order Insectivora. Part 1. Pp. 1 - 29, in The mammals of Africa: An identification manual (J. Meester and H. W. Setzer, eds.). [issued 22 Aug 1977]. Smithsonian Institution Press, Washington, D. C., not continuously paginated.", "Gureev, A. A. 1979. Fauna SSSR, Mlekopitayutschie, tom. 4, vyp. 2. Nasekomoyadnye ... [Fauna of the USSR, Mammals, vol. 4, pt. 2. Insectivores (Mammalia, Insectivora)]. Nauka, Leningrad, 501 pp. (in Russian)."]}
An index for Brouwer homeomorphisms and homotopy Brouwer theory
Creators: name: Roux, Frédéric Le
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We use the homotopy Brouwer theory of Handel to define a Poincar{é} index between two orbits for an orientation preserving fixed point free homeomorphism of the plane. Furthermore, we prove that this index is almost additive.
description: To appear in Ergodic Theory and Dynamical Systems
Generalized KdV equation subject to a stochastic perturbation
Creators: name: Millet, Annie
name: Roudenko, Svetlana
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: Primary: 60H15, 35R60, 35Q53, Secondary: 35L75, 37K10

description: We prove global well-posedness of the subcritical generalized Korteweg-de Vries equation (the mKdV and the gKdV with quartic power of nonlinearity) subject to an additive random perturbation. More precisely, we prove that if the driving noise is a cylindrical Wiener process on $L^2(\mathbb{R})$ and the covariance operator is Hilbert-Schmidt in an appropriate Sobolev space, then the solutions with $H^1(\mathbb{R})$ data are globally well-posed in $H^1(\mathbb{R})$. This extends results obtained by A. de Bouard and A. Debussche for the stochastic KdV equation.
An Experimental Investigation of Preference Misrepresentation in the Residency Match
Creators: name: Rees-Jones, Alex
name: Skowronek, Samuel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Econometrics (econ.EM)
subject: FOS: Economics and business

description: The development and deployment of matching procedures that incentivize truthful preference reporting is considered one of the major successes of market design research. In this study, we test the degree to which these procedures succeed in eliminating preference misrepresentation. We administered an online experiment to 1,714 medical students immediately after their participation in the medical residency match--a leading field application of strategy-proof market design. When placed in an analogous, incentivized matching task, we find that 23% of participants misrepresent their preferences. We explore the factors that predict preference misrepresentation, including cognitive ability, strategic positioning, overconfidence, expectations, advice, and trust. We discuss the implications of this behavior for the design of allocation mechanisms and the social welfare in markets that use them.