cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Controlled-NOT gate operating with single photons
Creators: name: Pooley, M. A.
name: Ellis, D. J. P.
name: Patel, R. B.
name: Bennett, A. J.
name: Chan, K. H. A.
name: Farrer, I.
name: Ritchie, D. A.
name: Shields, A. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The initial proposal for scalable optical quantum computing required single photon sources, linear optical elements such as beamsplitters and phaseshifters, and photon detection. Here we demonstrate a two qubit gate using indistinguishable photons from a quantum dot in a pillar microcavity. As the emitter, the optical circuitry, and the detectors are all semiconductor, this is a promising approach towards creating a fully integrated device for scalable quantum computing.
Assessment of Technical Competence for Central Venous Catheterization
Creators: name: Ma, Irene Wai Yan
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Education--Health
subject: Medicine and Surgery
subject: Health Education

description: Purpose Central venous catheterization (CVC) is a commonly performed procedure. Technical competence in its insertion is critical for patient safety reasons. It is unclear how competence should be diagnosed. Using a unified framework of validity that outlines five sources of validity evidence, results from three published studies are presented on the use of a formative simulation-based examination, assessing for technical competence in video-recorded performances of CVC by medical trainees. Methods Validity evidence based on content: study one evaluated all available published assessment tools on CVC performances. Items on each tool were classified into competency themes. Response process: study two compared the reliability measures of assessment data of 18 video-recorded performances with direct observation, rated by two independent, trained raters. Adequacy of video recordings was reviewed qualitatively. Internal structure: study three used principal component analysis to assess for the dimensions assessed by an 8-item global rating scale. Relationship with other variables: scores rated by two checklists were correlated with global assessment, confidence and number of needle attempts. Consequences of testing: the ability of checklists to identify procedural competence was assessed. Results Of the 25 published checklists identified, only six (20%) assessed each of the seven competency domains. The most frequently under-represented domains were “team working” and “communication with the patient.” Assessments between video-recorded performances and direct observations were comparable. However, wire handling was not fully captured in 13 of the 18 videos (72%). Of these, 5 (38%) were considered to have impacted rating. Drape handling was not fully captured in 17 videos (94%) and felt to be consequential to rating in 9 (53%). Two dimensions were identified in the global rating scale: technical ability and procedural safety, accounting for 84.1% of the overall variance. For both checklists, scores correlated positively with weighted factor scores on technical ability, but negatively with scores on safety. Both checklists demonstrated lower specificity than sensitivity in the diagnosis of competence, and high checklist scores did not preclude incompetence. Discussion Together, these three studies presented validity evidence from multiple sources that support the use of the simulation-based examination in identifying trainees who may benefit from further training.
On the Use of Hybrid Compact Polarimetric SAR for Ship Detection
Creators: name: Atteia Allah, Ghada Emam Mohamed
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Engineering--Electronics and Electrical
subject: Synthetic Aperture Radar
subject: Compact polarimetry
subject: Ship detection
subject: Stokes parameters
subject: Quad-pol reconstruction
subject: Hybrid polarity

description: Maritime surveillance is an issue of particular interest and importance for countries bordering on the sea. Monitoring and controlling maritime activities are essential for these countries to assert their sovereignty over their waters. Ship detection is one of the most vital elements of maritime control. Traditional surveillance methods suffer from narrow coverage and high cost to achieve comprehensive surveillance. However, Synthetic Aperture Radar (SAR) with its ability to provide images covering wide geographic areas and acquired with a variety of imaging modes, polarization configurations, incidence angles and resolutions may be considered as a promising alternative/complement for existing methods. Quad-polarimetric SAR data has been used successfully for ship detection. However, narrow swath of quad-polarimetric SAR promotes the urgent need to explore ship detectors for dual-polarimetric systems. Compact polarimetric (CP) SAR has high potential of providing more information than linear dual-polarimetric SAR. Even wider swaths will be provided in many of the CP imaging modes of the upcoming Canadian Radarsat Constellation Mission (RCM) SAR to be launched in 2018. In this thesis, the use of CP SAR for ship detection is explored. To fulfill this purpose, two novel contributions are introduced. The first is an investigation study of the possibility and benefits of using pseudo-quad data for improved ship detection. This is achieved by comparing the ship detection performance of dual-polarized CP and pseudo-quad data to linear and circular dual-polarized SAR. The pseudo-quad data is generated by a reconstruction algorithm that aims to reconstruct some elements of the quad-pol covariance matrix from CP data specifically for maritime applications. This study is applied on Radarsat-2 scenes with fine resolution and simulated medium and low resolution RCM data . The effect of spatial resolution, ship orientation and incidence angle on the detection performance has been explored. The second contribution is a new hybrid ship detection algorithm that utilized CP Stokes parameters and some of their derived parameters for ship detection. The pre-screener of the algorithm merges three detection strategies to declare candidate ships and the discriminator uses a CP decomposition technique to discriminate ships from false alarms based on the type of scattering mechanism. The proposed detection algorithm is applied to a number of simulated RCM scenes with medium and low resolutions. The findings of this thesis suggest the usefulness of CP reconstruction for improved ship detection. For the hybrid ship detection algorithm, a detection rate of 100% is obtained for medium resolution data and about 98% for low resolution data.
title: Assessment of trimethylamine-N-oxide at the blood-cerebrospinal fluid barrier
title: results from 290 lumbar punctures
titleType: AlternativeTitle
Creators: name: Enko, Dietmar
name: Zelzer, Sieglind
name: Niedrist, Tobias
name: Holasek, Sandra
name: Baranyi, Andreas
name: Schnedl, Wolfgang J.
name: Herrmann, Markus
name: Meinitzer, Andreas
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Biomarkers
subject: Blood-cerebrospinal fluid barrier
subject: Liquid chromatography-tandem mass spectrometry
subject: Trimethylamine-N-oxide
subject: 610

description: Recently, the microbiome-derived trimethylamine-N-oxide (TMAO) was shown to be present in human cerebrospinal fluid (CSF). However, data on the potential of TMAO crossing the blood-CSF barrier are still lacking. This retrospective study aimed at investigating possible associations between the CSF/serum albumin (QALB) and TMAO (QTMAO) quotient and evaluating QTMAO values in individuals with and without blood-CSF barrier dysfunction. A total of 290 patients, who underwent diagnostic lumbar puncture with QALB and QTMAO determination, were evaluated. Serum and CSF TMAO measurements were performed on a tandem mass spectrometry SCIEX QTRAP 4500 (Applied Biosystems, Framingham, MA, USA) coupled with an Agilent 1260 Infinity HPLC system (Agilent Technologies Santa Clara, CA, USA). Serum and CSF albumin were measured on the Atellica® NEPH 630 system (Siemens Healthineers, Erlangen, Germany). CSF TMAO levels were positively correlated with serum TMAO levels (ρ = 0.709, p < 0.001). The QALB was significantly associated with the QTMAO (ß-coefficient = 0.312; p < 0.001). A total of 117 patients with blood-CSF barrier dysfunction had significantly higher median (Q1 – Q3) QTMAO values (4.7 (2.8 – 7.5) vs. 3.8 (2.5 – 5.7) x 10-1, p = 0.002) compared to 173 individuals with normal blood-CSF barrier function. CSF and serum TMAO concentrations were significantly associated in 290 CSF/serum pairs from lumbar punctures of clinical routine. QALB showed a relevant influence on QTMAO. Present results indicate that TMAO may cross the blood-CSF barrier.
description: EXCLI Journal;Vol. 19. 2020, pp.1275-1281
Innovative Approaches to Teaching and Learning
Creators: name: Filipe, Sandra
name: Aragonez, Teresa
name: Saur-Amaral, Irina
Publisher: name: International Journal of Marketing, Innovation and Strategy
Year: 2023

description: The main goal of this paper is to describe a specific teaching-learning project implemented in two higher education courses – Bachelor in Marketing and Master in Competitiveness and Business Development, offered at a higher education institution. The project integrated Project Based Learning (PBL) methodologies and authentic learning, supported by technology, with Sustainable Development Goals (SDGs), studying real companies from different industries, and aiming to improve the quality of the learning experience, students’ motivation and academic success. A total of 300 students were involved in the first semester of the year 2022/2023. The idea of sustainable cocreation was at the base of this pedagogical innovation project, so that students may become aware and assume responsibility on the impact of marketing, strategy and competitiveness decisions in the contemporary society. Students were challenged to include in their works a proposal of actions that had positive impact and contributed to the SDGs defined by the United Nations and to reflect and measure the potential impact of these actions at the level of the community. From an operational perspective, students developed different activities in their academic works, in four different curricular units, in line with the educational level and syllabus of each curricular unit, always related to real companies from different industries and supported by different technologies, using different immersive learning experiences where students could combine authentic learning and SDGs analysis.
description: International Journal of Marketing, Innovation and Strategy, vol. 1 n.º 2 (2023)
LncRNA HOTAIR promotes MPP+-induced neuronal injury in Parkinson’s disease by regulating the miR-874-5p/ATG10 axis
Creators: name: Zhao, Jingya
name: Li, Hongli
name: Chang, Na
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Parkinson’s disease
subject: HOTAIR
subject: miR-874-5p
subject: ATG10
subject: Neuronal injury
subject: 610

description: Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. Long non-coding RNAs (lncRNAs) play an important role in many neurological diseases, including PD. This study aimed to investigate the role of lncRNA HOX transcript antisense RNA (HOTAIR) in PD pathogenesis and its potential mechanism. SK-N-SH cells were exposed to 1-methyl-4-phenylpyridinium (MPP+) to mimic PD model in vitro. The levels of HOTAIR, miR-874-5p and autophagy-related 10 (ATG10) were determined by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot assay. Cell viability and apoptosis were assessed by Cell Counting Kit-8 (CCK-8) assay and flow cytometry. The expression of apoptosis-related proteins was measured by western blot. The levels of neuroinflammation-related factors were detected by enzyme-linked immunosorbent assay (ELISA). Commercial kits was used to monitor lactate dehydrogenase (LDH) activity, reactive oxygen (ROS) generation and superoxide dismutase (SOD) activity. The interaction among HOTAIR, miR-874-5p and ATG10 were verified by dual-luciferase reporter assay or RNA immunoprecipitation (RIP) assay. HOTAIR and ATG10 were up-regulated, and miR-874-5p was down-regulated in dose- and time-dependent manners in MPP+-treated SK-N-SH cells. HOTAIR knockdown reduced MPP+-induced neuronal damage. HOTAIR aggrandized MPP+-triggered neuronal injury by sponging miR-874-5p. Also, miR-874-5p attenuated MPP+-triggered neuronal damage by targeting ATG10. Moreover, HOTAIR regulated ATG10 expression via sponging miR-874-5p. HOTAIR promoted MPP+-induced neuronal injury via modulating the miR-874-5p/ATG10 axis in SK-N-SH cells.
description: EXCLI Journal;Vol. 19 2020
Fully Autonomous Programming with Large Language Models
Creators: name: Liventsev, Vadim
name: Grishina, Anastasiia
name: Härmä, Aki
name: Moonen, Leon
Publisher: name: arXiv
Year: 2023
Subjects: subject: Software Engineering (cs.SE)
subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Current approaches to program synthesis with Large Language Models (LLMs) exhibit a "near miss syndrome": they tend to generate programs that semantically resemble the correct answer (as measured by text similarity metrics or human evaluation), but achieve a low or even zero accuracy as measured by unit tests due to small imperfections, such as the wrong input or output format. This calls for an approach known as Synthesize, Execute, Debug (SED), whereby a draft of the solution is generated first, followed by a program repair phase addressing the failed tests. To effectively apply this approach to instruction-driven LLMs, one needs to determine which prompts perform best as instructions for LLMs, as well as strike a balance between repairing unsuccessful programs and replacing them with newly generated ones. We explore these trade-offs empirically, comparing replace-focused, repair-focused, and hybrid debug strategies, as well as different template-based and model-based prompt-generation techniques. We use OpenAI Codex as the LLM and Program Synthesis Benchmark 2 as a database of problem descriptions and tests for evaluation. The resulting framework outperforms both conventional usage of Codex without the repair phase and traditional genetic programming approaches.
description: Accepted for publication in the Genetic and Evolutionary Computation Conference (GECCO 2023)
Quantum Private Information Retrieval with Sublinear Communication Complexity
Creators: name: Gall, François Le
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Computational Complexity (cs.CC)
subject: Cryptography and Security (cs.CR)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: This note presents a quantum protocol for private information retrieval, in the single-server case and with information-theoretical privacy, that has O(\sqrt{n})-qubit communication complexity, where n denotes the size of the database. In comparison, it is known that any classical protocol must use Ω(n) bits of communication in this setting.
description: 4 pages
Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
Creators: name: Abd Rashid, Norhashima
name: Hussan, Farida
name: Hamid, Asmah
name: Adib Ridzuan, Nurul Raudzah
name: Halim, Syarifah Aisyah Syed Abdul
name: Abdul Jalil, Nahdia Afiifah
name: Najib, Nor Haliza Mohamad
name: Teoh, Seong Lin
name: Budin, Siti Balkis
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Apoptosis
subject: Cisplatin
subject: Hepatotoxicity
subject: Inflammation
subject: Polygonum minus essential oil
subject: Oxidative stress
subject: 610

description: Oxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of Polygonum minus essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly divided into seven groups: control, cisplatin, β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg + cisplatin (PmEO100CP), PmEO 200 mg/kg + cisplatin (PmEO200CP), PmEO 400 mg/kg + cisplatin (PmEO400CP) and PmEO 400 mg/kg (PmEO400). Rats in the BCP, PmEO100CP, PmEO200CP, PmEO400CP and PmEO400 group received respective treatment orally for 14 consecutive days prior to cisplatin injection. All animals except for those in the control group and PmEO400 were administered with a single dose of cisplatin (10 mg/kg) intraperitoneally on day 15 and all animals were sacrificed on day 18. PmEO100CP pretreatment protected against cisplatin-induced hepatotoxicity by decreasing CYP2E1 and indicators of oxidative stress including malondialdehyde, 8-OHdG and protein carbonyl which was accompanied by increased antioxidant status (glutathione, glutathione peroxidase, superoxide dismutase and catalase) as compared to cisplatin group. PmEO100CP pretreatment also modulated changes in liver inflammatory markers (TNF-α, IL-1α, IL-1β, IL-6 and IL-10). PmEO100CP administration also notably reduced cisplatin-induced apoptosis significantly as compared to cisplatin group. In conclusion, our results suggested that P. minus essential oil at a dose of 100 mg/kg may protect against cisplatin-induced hepatotoxicity possibly via inhibition of oxidative stress, inflammation and apoptosis.
description: EXCLI Journal;Vol. 19. 2020, pp.1246-1265
Bench-Breakers? Women Judges in Prairie Canada 1916 - 1980
Creators: name: Jakobsen, Pernille
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: History--Canadian
subject: History of Canada, Women Judges, Prairies

description: Between 1916 and 1980 a small number of women magistrates and judges adjudicated in courtrooms across the Prairie Provinces of Alberta, Saskatchewan, and Manitoba. Often they worked in “family court,” through its historic incarnations including juvenile courts, women’s courts, and domestic relations tribunals. The first of these women, practicing between 1916 and 1935, included magistrates Emily Murphy and Alice Jamieson in Alberta, and judge Jean Ethel MacLachlan in Saskatchewan. None of these women held law degrees or membership within the legal profession, but all three had a “motherly outlook.” Murphy and Jamieson’s expertise was derived from their leading roles in influential women’s organizations and connections to the suffrage and dower campaigns. MacLachlan’s authority developed from her remunerated work with the Children’s Aid Society, and she received significant support from the Regina Local Council of Women. They worked within quasi-judicial courts, associated with volunteer-based social welfare initiatives, appended on to, rather than integrated into, existing established legal institutions. During the 1930s, these Prairie women magistrates and judges lost their positions in the midst of economic and professional rearrangements. In the meanwhile, a vibrant women’s legal culture, assisted by developments in legal education and professionalism, emerged to provide the basis for a rebirth of women judges in the 1950s. The next cohort of Prairie women judges was appointed to the bench beginning in 1957 with Nellie McNichol Sanders. In common with their early-twentieth century precursors, the media often positioned women judges as “role mothers” by highlighting their maternal, rather than professional, suitability for the courtroom even though all women judges held law degrees and were members of provincial law societies. Illustrative of continued connections with the volunteer sector, these women judges pursued human rights and advocated the re-dressing of inequitable laws and customs for children, women, and other vulnerable groups including Aboriginal persons. At the same time, women judges’ individual perspectives suggest discord with the egalitarian goals of the late 1960s and early 1970s women’s movement, and reveal that not all women judges were feminist actors. In the final analysis, this dissertation uses an unconventional timeline to argue that Prairie women judges were part of a broader movement of change associated with continuities and changes in the women’s movement and in legal professionalism. Women judges worked within the prescriptions imposed by their times, contemporary legal codes, and society’s expectation of family courts. Their public work in the Prairie Provinces reveals that legal and social change was influenced by local, national, and international influences; change did not move uniformly from Ontario to the West.
Curcumin as an indirect methylation inhibitor modulates the effects of Toxoplasma gondii on genes involved in male fertility
Creators: name: Saki, Jasem
name: Sabaghan, Mohamad
name: Arjmand, Reza
name: Teimoori, Ali
name: Rashno, Mohammad
name: Saki, Ghasem
name: Shojaee, Saeedeh
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Toxoplasma gondii
subject: DNMTs
subject: Gene expression
subject: NF‑κB
subject: DNA methylation
subject: 610

description: Toxoplasma gondii is a common protozoan parasite, which infects warm-blooded mammals, including mice and humans, throughout the world. The negative effects of T. gondii infection on the human reproductive system have been documented, especially in females. However, only few studies have examined the effects of T. gondii infection on the male reproductive system. Previous research shows that T. gondii can induce DNA methylation in some gene promoters, which are key regulators of spermatogenesis. Therefore, this study aimed to evaluate the effects of curcumin on the activity of DNA methyltransferases (DNMTs), as well as selected genes, involved in spermatogenesis in spermatogenic cells. In the spermatogenic cells exposed to T. gondii, there was a significant increase in DNMT1 and DNMT3A gene expression and a significant reduction in HSPA1A, MTHR, and DAZL gene expression, compared to the controls. The present results showed that curcumin could regulate changes in T. gondii-mediated gene expression. The effect of T. gondii on DNMT activity was also investigated in this study. A 40 % increase in DNMT activity was observed due to T. gondii infection. However, DNMT activity was restored by treatment with 20 μM curcumin for eight hours. The results revealed that T. gondii increases the NF-κB activity, compared to the control group. The increase in NF-κB activity, induced by T. gondii, was inhibited by curcumin. In conclusion, T. gondii, by increasing DNMT expression and activity, leads to an increase in NF-κB activity in cells. On the other hand, curcumin reduced DNA methylation, induced by T. gondii, owing to its NF-κB-inhibiting properties. Therefore, curcumin, as a hypomethylating agent, can be potentially used to alleviate the negative effects of T. gondii on the male reproductive system.
description: EXCLI Journal;Vol. 19. 2020, pp.
Electronic Supplementary Material for: A comprehensive and cost-effective approach for investigating passive dispersal in minute invertebrates with case studies of phytophagous eriophyid mites
Creators: name: Kuczyński, Lechosław
name: Radwańska, Anna
name: Karpicka-Ignatowska, Kamila
name: Laska, Alicja
name: Lewandowski, Mariusz
name: Rector, Brain G.
name: Majer, Agnieszka
name: Raubic, Jarosław
name: Skoracka, Anna
Publisher: name: Zenodo
Year: 2020

description: Filename: ESM_1.pdf Photos and technical drawings of the 'wind-transience' tunnel, 'vector-transience' tunnel and 'departure' tunnel, and the scheme of Lego Mindstorms NXT 2.0 - engine program for a robotic mammalian vector simulation. Filename: ESM_2.R and ESM_3.R Reproducible examples on how to estimate dispersal parameters using the methodology proposed in this article. Filename: ESM_4.pdf Estimated costs of devices construction in USD.
 Filename: ESM_5.mp4 Video 3D model of the ‘wind-transience’ tunnel. Filename: ESM_6.mp4 Video 3D model of the ‘vector-transience’ tunnel. Filename: ESM_7.mp4 Video 3D model of the ‘departure’ tunnel. Filename: ESM_8.mp4 Video of eriophyid mite behaviors observed within the ‘departure’ tunnel.
description: The study was funded by the National Science Centre (NSC) grant no. 2016/21/B/NZ8/00786, and supported by NSC PhD scholarship no. 2018/28/T/NZ8/00060 awarded to Agnieszka Majer and NSC PhD scholarship no. 2019/32/T/NZ8/00151 awarded to Alicja Laska. Agnieszka Majer and Alicja Laska scholarships were founded by European Social Funds POWR.03.02.00–00–I006/17. Alicja Laska is a scholarship holder from the Adam Mickiewicz University Foundation awarded in 2019/2020
Refining urban design governance: an investigation of the urban design assessment processes in Aotearoa New Zealand
Creators: name: Batchelor, David
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: classificationCode: 120599
subject: Urban and Regional Planning not elsewhere classified
classificationCode: 120199
subject: Architecture not elsewhere classified

description: No description supplied
Incidence of Adverse Reaction of Drugs used in COVID-19 Management: A Retrospective, Observational Study
Creators: name: LEE Jia Yin
name: ANG Abby Shoon Yeun
name: MOHD ALI Nurdalila
name: ANG Li Min
name: OMAR Azura
Publisher: name: Zenodo
Year: 2021
Subjects: adverse drug reaction
COVID-19
COVID-19 management
medication

description: Background:
 The safety profile of medications for COVID-19 remains unknown in Malaysia. Our study aims to establish the incidence of adverse drug reaction (ADR) for drugs used in COVID-19 management in a Malaysian tertiary hospital. Methods:
 This retrospective observational study enrolled patients started on drugs for COVID-19 in Sungai Buloh Hospital from 1 March 2020 to 31 May 2020. Suspected ADRs were evaluated with a trigger tool of pre-defined laboratory values or the adverse events listed in the registered product insert. Causality assessment was conducted when an ADR was suspected using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) system, and only cases classified as certain, probable and possible ADR were analysed. Data analysis was completed with descriptive, univariate and multivariate analysis. Results:
 The study (N = 1,080) identified 217 patients (20.1%) who experienced ADR, with 246 adverse events detected. Most events were related to the gastrointestinal (43.5%), hepatobiliary (36.2%) and cardiac (16.3%) systems. The most commonly suspected drugs were atazanavir (52.7%), chloroquine (36.8%) and lopinavir/ritonavir (34.6%). The independent risk factors of ADR were female (adjusted odds ratio (OR): 1.53; 95% CI 1.06-2.20; p = 0.024), diagnosis of COVID-19 stage 3 (adjusted OR: 2.58; 95% 1.20-5.55; p = 0.015) and stage 4 (adjusted OR: 4.17; 95% CI 1.79-9.73; p = 0.001), and the number of COVID-19 drugs (adjusted OR: 3.34; 95% CI 2.51-4.44; p < 0.001). Conclusion:
 Medications used in COVID-19 management had resulted in one in five patients experiencing ADR. Our study suggests a similar safety profile when used for FDA-approved indications.
 Disclaimer: Abstract text might vary slightly from what is displayed in the e-poster.
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) in August 18-20, 2021. https://nccrconference.com.my/
An appraisal of Understanding Pressure Effects on Structural, Optical, and Magnetic Properties of CsMnF_{4} and Other 3d^{n} Compounds
Creators: name: Rodriguez, Fernando
Publisher: name: arXiv
Year: 2025
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A recently published article in Inorganic Chemistry (DOI: 10.1021/acs.inorgchem.4c00599) offers theoretical calculations on the effects of pressure on the structural, optical, and magnetic behavior of CsMnF_{4}. Although a thorough theoretical and experimental understanding of this material is certainly warranted, there are previously published experimental results on CsMnF_{4}, as well as on other Mn^{3+} fluorides, under pressure that have not been considered in the aforementioned article. These findings raise questions about the accuracy of the theoretical estimates and the validity of the methodology used to determine the reported structural, optical, and magnetic properties. This paper intends to provide the readers of Inorganic Chemistry and the broader scientific community with a perspective on a publication that directly contradicts interpretations presented in prior research.
description: 19 pages, 8 figures
Discovery of period doubling in BL Herculis stars of the OGLE survey. Observations and theoretical models
Creators: name: Smolec, R.
name: Soszynski, I.
name: Moskalik, P.
name: Udalski, A.
name: Szymanski, M. K.
name: Kubiak, M.
name: Pietrzynski, G.
name: Wyrzykowski, L.
name: Ulaczyk, K.
name: Poleski, R.
name: Kozlowski, S.
name: Pietrukowicz, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the discovery of a period doubling behaviour in a 2.4d BL Herculis-type variable of the Galactic bulge. Another bulge BL Her-type star (P=2.25d) is a strong period doubling candidate. Both objects have been identified with the OGLE-III photometry. Possibility of period doubling in this type of pulsators has been predicted almost twenty years ago by Buchler & Moskalik. Our finding is the first observational confirmation of their theoretical results. Discovery of the first BL Herculis star showing the period doubling effect motivates a new theoretical investigation with the state-of-the-art convective pulsation codes. We present the results of initial model survey, specifically aimed at studying the observed period-doubled BL Her variable. All of our non-linear models have P=2.4d. The computations confirm that the period doubling effect is caused by the 3:2 resonance between the fundamental mode and the first overtone, as indicated by earlier radiative models of Buchler & Moskalik. Comparison of the computed and the observed light curves allows to constrain the parameters of the star, in particular its metallicity, which appears to be high, Z is approximately 0.01. The recent evolutionary tracks put also constraint on the mass of the star, which is close to M=0.50 solar masses.
description: 18 pages, 18 figures, accepted for publication in MNRAS
Compilation for real-time systems : an overview of the WCET-aware C compiler WCC
Creators: name: Oehlert, Dominic Paul
name: Luppold, Arno
name: Falk, Heiko
Publisher: name: TUHH Universitätsbibliothek
Year: 2018
Subjects: subject: Real-Time
subject: Compiler
subject: WCC
subject: Optimization
subject: 600: Technik
subject: 620: Ingenieurwissenschaften
subject: 600
subject: 620

description: Traditionell finden Design und zeitliche Analyse eines eingebetteten harten Echtzeitsystems getrennt voneinander statt. Dies führt zu einem komplexen Designfluss, der menschliche Interaktion benötigt. Weiter optimieren Standardcompiler in Bezug auf die durchschnittliche Performanz, so dass der Systemdesigner nicht bei der Optimierung hinsichtlich der schlimmstmöglichen Programmlaufzeit unterstützt wird. Der WCET-Aware C Compiler WCC verbessert diese Situation, indem Planbarkeitsanalysen eng in den Compilierungs- und Optimierungsprozess mit eingebuden werden. Weiter bietet der Compiler gezielte Möglichkeiten um echtzeitbewusst Optimierungen durchzuführen und dabei gezielt mikroarchitekturelle Eigenschaften der jeweiligen Zielarchitektur auszunutzen. Hierdurch kann automatisiert Programmcode für Mehrprozess- und Mehrprozessor-systeme erzeugt erden, der alle Zeitschranken einhält.
description: Traditionally, design of embedded hard real-time software and timing analysis are decoupled from each other, leading to complicated design flows involving human interaction. Furthermore, traditional compilers optimize for average-case performance so that no tool support exists supporting the designer to systematically reduce Worst-Case Execution Times in case that deadlines are missed. The WCET-Aware C Compiler WCC improves this situation by tightly schedulability analyses into the compilation and optimization flow. Furthermore, the compiler features dedicated real-time aware optimizations and exploits detailed architectural knowledge so that schedulable code meeting deadlines can be generated automatically, even for multitask or multicore systems.
Negative impact of COVID-19 pandemic on sleep quantitative parameters, quality, and circadian alignment
Creators: name: Salehinejad, Mohammad Ali
name: Majidinezhad, Maryam
name: Ghanavati, Elham
name: Kouestanian, Sahar
name: Vicario, Carmelo M.
name: Nitsche, Michael A.
name: Nejati, Vahid
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: COVID-19
subject: Circadian misalignment
subject: Chronotype
subject: Quarantine
subject: Lifestyle
subject: Sleep
subject: 610

description: The COVID-19 pandemic has spread worldwide, affecting millions of people and exposing them to home quarantine, isolation, and social distancing. While recent reports showed increased distress and depressive/anxiety state related to COVID-19 crisis, we investigated how home quarantine affected sleep parameters in healthy individuals. 160 healthy individuals who were in home quarantine in April 2020 for at least one month participated in this study. Participants rated and compared their quantitative sleep parameters (time to go to bed, sleep duration, getting-up time) and sleep quality factors, pre-and during home quarantine due to the COVID-19 pandemic. Furthermore, participants’ chronotype was determined to see if sleep parameters are differentially affected in different chronotypes. Time to fall asleep and get-up in the morning were significantly delayed in all participants, indicating a significant circadian misalignment. Sleep quality was reported to be significantly poorer in all participants and chronotypes. Poor sleep quality included more daily disturbances (more sleep disturbances, higher daily dysfunctions due to low quality of sleep) and less perceived sleep quality (lower subjective sleep quality, longer time taken to fall asleep at night, more use of sleep medication for improving sleep quality) during home quarantine. Home quarantine due to COVID-19 pandemic has a detrimental impact on sleep quality. Online interventions including self-help sleep programs, stress management, relaxation practices, stimulus control, sleep hygiene, and mindfulness training are available interventions in the current situation.
description: EXCLI Journal;Vol. 19. 2020, pp.1297-1308
Towards code obfuscation through video game crowd sourcing
Creators: name: Dey, Sutapa
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Computer Science
subject: Code Obfuscatio
subject: Crowdsourcing
subject: Video games

description: Code obfuscation is used to prevent software piracy as well as to avoid reverse engineering of malicious software (malware). From the perspective of malware authors, unique approaches to obfuscate code are beneficial to avoid detection. There have been instances where malware authors have leveraged the support of unsuspecting humans for malicious activities. In this work, we analyze if humans can obfuscate code without knowing that they are generating code. We opted to examine if video games could be a possible channel to extract code obfuscations from humans. In this thesis, we discuss the development of a new game that is designed to generate obfuscated code during gameplay. We also research if code obfuscations are possible using existing games. We assess our implementation to check if it is feasible to generate diverse obfuscated versions of original code based on the randomness generated in the game due to player interactions or movements in video games. Lastly, we discuss the limitations of this approach and recommend some future work.
Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines
Creators: name: Elbehairi, Serag Eldin I.
name: Ezzat Ahmed, Ahmed
name: Alshati, Ali A.
name: Al-Kahtani, Mohammed A.
name: Alfaifi, Mohammad Y.
name: Alsyaad, Khalid M.
name: Alalmie, Ali Yahya A.
name: Elimam Ahamed, Mohammed M.
name: Moustafa, Mahmoud F.
name: Alhag, Sadeq K.
name: Al-Abd, Ahmed M.
name: Abbas, Ahmed M.
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Prosopis juliflora
subject: Cytotoxicity
subject: Apoptosis
subject: cancer
subject: MCF-7
subject: HepG2
subject: LS-174T
subject: 610

description: Prosopis juliflora (P. juliflora) is a widespread phreatophytic tree, which belongs to the Fabaceae family. The goal of the present study is to investigate the potential anti-cancer effect of P. juliflora leave extracts and to identify its chemical composition. For this purpose, MCF-7 (breast), HepG2 (liver), and LS-174T (colorectal) cancer cell lines were cultivated and incubated with various concentrations of P. juliflora leave extracts, and its impact on cell viability, proliferation, and cell cycle stages was investigated. P. juliflora leave extracts induced concentration-dependent cytotoxicity against all tested cancer cell lines. The calculated IC50 was 18.17, 33.1 and 41.9 μg/ml for MCF-7, HePG2 and LS-174T, respectively. Detailed analysis revealed that the cytotoxic action of P. juliflora extracts was mainly via necrosis but not apoptosis. Moreover, DNA content flow cytometry analysis showed cell-specific anti-proliferative action and cell cycle stages arrest. In order to identify the anti-cancer constituents of P. juliflora, the ethyl extracts were analyzed by liquid chromatography-mass spectrometry. The major constituents identified in the ethyl extracts of P. juliflora leaves were hydroxymethyl-pyridine, nicotinamide, adenine, and poly-(methyl methacrylate) (PMMA). In conclusion, P. juliflora ethyl acetate extracts have a potential anti-cancer effect against breast adenocarcinoma, hepatocellular carcinoma, and colorectal adenocarcinoma, and is enriched with anti-cancer constituents.
description: EXCLI Journal;Vol. 19. 2020, pp.1282-1294
Hierarchical information clustering by means of topologically embedded graphs
Creators: name: Song, Won-Min
name: Di Matteo, T.
name: Aste, Tomaso
Publisher: name: arXiv
Year: 2011
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Data Structures and Algorithms (cs.DS)
subject: Biological Physics (physics.bio-ph)
subject: Quantitative Methods (q-bio.QM)
subject: Computational Finance (q-fin.CP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences
subject: FOS: Economics and business

description: We introduce a graph-theoretic approach to extract clusters and hierarchies in complex data-sets in an unsupervised and deterministic manner, without the use of any prior information. This is achieved by building topologically embedded networks containing the subset of most significant links and analyzing the network structure. For a planar embedding, this method provides both the intra-cluster hierarchy, which describes the way clusters are composed, and the inter-cluster hierarchy which describes how clusters gather together. We discuss performance, robustness and reliability of this method by first investigating several artificial data-sets, finding that it can outperform significantly other established approaches. Then we show that our method can successfully differentiate meaningful clusters and hierarchies in a variety of real data-sets. In particular, we find that the application to gene expression patterns of lymphoma samples uncovers biologically significant groups of genes which play key-roles in diagnosis, prognosis and treatment of some of the most relevant human lymphoid malignancies.
description: 33 Pages, 18 Figures, 5 Tables
Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction
Creators: name: Ye, Xiaofeng
name: Kong, Wen
name: Zafar, Mohammad Ishraq
name: Zeng, Junchao
name: Yang, Rui
name: Chen, Lu-Lu
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Vascular endothelial growth factor B
subject: Non-alcoholic fatty liver disease
subject: Blood pressure
subject: Renal dysfunction
subject: Metabolism
subject: 610

description: Vascular endothelial growth factor B (VEGF-B) is a critical metabolic regulator in insulin resistance, and lipid distribution. We intended to ascertain the relationship between circulating VEGF-B and non-alcoholic fatty liver disease (NAFLD) in the general public. We recruited a total of 194 general participants for a routine physical health examination; of these, 84 participants were identified with NAFLD and 110 without NAFLD based on ultrasonographic findings. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), HbA1c, liver function, kidney function, plasma VEGF-B levels and indexes of metabolic syndrome (blood pressure, fasting plasma glucose, fasting lipids) were evaluated. Plasma VEGF-B values were significantly higher in individuals with NAFLD compared to those without NAFLD (P = 0.022), and analysis of covariance confirmed this result. VEGF-B showed a positive correlation with γ-glutamyl transpeptidase (γ-GT) and HOMA-IR in univariate analysis (q = 0.242; P = 0.001; q =0.174; P = 0.019, respectively). Multiple linear regression analysis showed that γ-GT and ALT were independently correlated with VEGF-B even after adjusted for gender and age (q = 0.286; P = 0.01; q =0.237; P = 0.033, respectively). Moreover, plasma VEGF-B showed a powerful correlation with blood pressure and renal dysfunction. Plasma VEGF-B might be a new clinical variable related to NAFLD and could be a proper biomarker for the early detection of hypertension and renal dysfunction. However, further studies with large cohorts’ size are warranted to validate our findings.
description: EXCLI Journal;Vol. 19. 2020, 1186-1195
Mobile Mapping Using Smartphones
Creators: name: Al-Hamad, Amr
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Geotechnology
subject: MMS
subject: Photogrammetry
subject: Smartphones

description: This thesis details the development of a mobile mapping system (MMS) using smartphones and investigates its ability to be a major source for Geographic Information System (GIS) and mapping applications. Nowadays, smartphones contain all the required components for any MMS (i.e., Global Positioning System (GPS) receiver, a digital camera, accelerometers, gyroscopes, and magnetometers). However, the accuracy of the sensors in smartphones is poor, which is the main drawback of using smartphones for mapping applications. In this thesis, two Android applications were developed to capture synchronized images or videos with various sensors measurements. Using a smartphone’s GPS receiver, its initial positions at the instants of exposure can be estimated; and a smartphone’s initial orientation parameters can be calculated using its accelerometers and magnetometers sensors. These initial values, which are called the Exterior Orientation Parameters (EOPs) and the initial Interior Orientation Parameters (IOPs) of the camera in use, are corrected using epipolar geometry constraints along with a set of automatically matched points between each two consecutive images. The corrected EOPs and IOPs are then used to estimate the 3D coordinates of the interest points using a developed bundle adjustment software application. The implementation of the prototype system is also shown, and all of the methods utilized to obtain the final mapping results are detailed. Using this prototype system, examples of the mapping results are shown where the absolute maximum mapping errors did not exceed 0.32 and 0.5 meter in the horizontal and vertical directions respectively using six captured images and two control points. Other obtained mapping results also are presented in this thesis to demonstrate the developed system’s ability to obtain mapping results efficiently, by pedestrians or from a moving vehicle, using both the captured images and recorded videos.
title: Association between resilience and a functional polymorphism in the serotonin transporter (SLC6A4) gene
title: a meta-analysis
titleType: AlternativeTitle
Creators: name: González-Giraldo, Yeimy
name: Forero, Diego A.
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Resilience
subject: Genetics
subject: FOS: Biological sciences
subject: SLC6A4 gene
subject: 5HTTLPR Polymorphism
subject: Meta-analysis
subject: 610

description: Resilience is a mechanism used by humans to adapt to adverse situations. It is a protective factor against mental health problems. This process can be influenced by environmental and genetic factors. Several genes have been associated with interindividual differences in resilience levels, but the results are inconclusive. Therefore, the aim of this meta-analysis was to evaluate the effect of a functional polymorphism (5-HTTLPR) in the SLC6A4 gene on resilience levels. A search in PubMed, HugeNavigator and Google Scholar databases was carried out and 16 studies about the association of 5-HTTLPR polymorphism and resilience in humans were identified. The OpenMeta[Analyst] program was employed to perform statistical analysis using a random-effects model. The final analysis included 9 studies, for a total of 4,080 subjects. Significant results were found when the standardized mean differences (SMD) of LL and SL carriers were compared, (SMD: -0.087 (confidence interval: -0.166 to -0.008; I2: 0 %); P value: 0.031). A significant result was also found in an analysis comparing SS/SL versus LL genotypes (SMD: -0.231; confidence interval: -0.400 to -0.061, P value: 0.008; I2: 0 %). This is the first meta-analysis performed to identify the pooled association of a functional polymorphism in the serotonin transporter gene and resilience. The current results suggest that the L/L genotype is associated with resilience. Further studies are necessary to elucidate the role of genetics on the resilience mechanisms.
description: EXCLI Journal;Vol. 19 2020
WASP-4b Transit Observations With GROND
Creators: name: Nikolov, Nikolay
name: Henning, Thomas
name: Koppenhoefer, Johannes
name: Lendl, Monika
name: Maciejewski, Gracjan
name: Greiner, Jochen
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Ground-based simultaneous multiband transit observations allow an accurate system parameters determination and may lead to the detection and characterization of additional bodies via the transit timing variations (TTVs) method. We aimed to (i) characterize the heavily bloated WASP-4b hot Jupiter and its star by measuring system parameters and the dependence of the planetary radius as a function of four (Sloan g', r', i', z') wavelengths and (ii) search for TTVs. We recorded 987 images during three complete transits with the GROND instrument, mounted on the MPG/ESO-2.2m telescope at La Silla Observatory. Assuming a quadratic law for the stellar limb darkening we derive system parameters by fitting a composite transit light curve over all bandpasses simultaneously. To compute uncertainties of the fitted parameters, we employ the Bootstrap Monte Carlo Method. The three central transit times are measured with precision down to 6 s. We find a planetary radius Rp = 1.413+/-0.020 RJup, an orbital inclination i = 88deg57'+/-0.45deg and calculate a new ephemeris, a period P = 1.33823144+/-0.00000032days and a reference transit epoch T0 = 2454697.798311+/-0.000046 (BJD). Analysis of the new transit mid-times in combination with previous measurements shows no sign of a TTV signal greater than 20s. We perform simplified numerical simulations to place upper-mass limits of a hypothetical perturber in the WASP-4b system.
description: 8 pages