cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A brief description of general TLR signaling pathway
Creators: name: Patra, Mahesh
Publisher: name: figshare
Year: 2016
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: A general overview of TLR signaling pathways. The full names of proteins shown in the figure are as follows. MyD88: Myeloid differentiation primary response protein 88; TIRAP: TIR-domain-containing adaptor protein; IRAK1: IL-1R-associated kinase 1; TRAF6: Tumor-necrosis-factor receptor-associated factor 6; IKK: Inhibitor of nuclear factor-κB (IκB)-kinase; IRF3: Interferon regulatory factor 3; TBK1: TRAF family member-associated NF-kappa-B activator (TANK) binding kinase; TRIF: TIR domain-containing adaptor–inducing interferon-β; TRAM: TRIF-related adaptor molecule. Two different but simultaneous pathways of signal transduction are known by which TLRs activate an adaptive immune response. One is through the adaptor MyD88, which is used by all TLRs except for TLR3. TLR3 operates through the TRIF pathway. TLR4 signals through both TRIF and MyD88 pathways. In the MyD88 pathway (also called the canonical pathway), conformational alteration of TLR homo/heterodimers allows binding of the TLR-TIR domain to the MyD88-TIR domains through homotypic TIR-TIR interaction. Subsequently, MyD88 recruits the kinase IRAK4 by death domain (DD)-DD interactions. IRAK4 binds and phosphorylates IRAK1, a natural substrate of IRAK4. Phosphorylated IRAK1 brings TRAF6 to the receptor complex. TRAF6 and IRAK1 dissociate from the receptor complex and form another complex with transforming growth factor β activated kinase 1 (TAK1), which coexists with the adaptor TAK1-binding protein 2 (TAB2) and activator TAB1 at the plasma membrane. IRAK1 phosphorylates both TAB1 and TAK1, and is degraded afterward, facilitating the translocation of TRAF6, TAK1, TAB1, and TAB2 to the cytoplasm where ubiquitin-conjugating enzyme 13 (UBC13) and ubiquitin-conjugating enzyme E2 variant 1 (UEV1A) ubiquitinate TRAF6, inducing activation of TAK1. Next, TAK1 phosphorylates mitogen-activated protein kinase (MAPK) and IKK complexes. The IKK complex, in turn, phosphorylates the IκB subunit of NF-κB, leading to its ubiquitination and subsequent degradation. This allows nuclear translocation of NF-κB to induce transcription of target genes. MyD88 works in concert with an upstream DD-lacking adaptor TIRAP, also called MyD88 adaptor-like (MAL), particularly during TLR1/2, 2/6, and TLR4 signaling. The TRIF pathway, also called the MyD88-independent or alternate signaling pathway, is specifically activated by TLR3 and TLR4. TRIF, along with a second, upstream adaptor, TRAM, stimulates IKK-ε and TBK1. IKK-ε, the counterpart of IKK in the canonical pathway, and TBK1 mediate activation and nuclear translocation of IRF3 to induce transcription of antiviral IFNs.The figure was redrawn from the published paper (own: http://dx.doi.org/10.1080/13543776.2016.1185415). The figure is uploaded in Wikicommons https://commons.wikimedia.org/wiki/File:TLR_Signaling_pathway.tif
Training American Listeners to Perceive Mandarin Tones: A Pilot Study
Creators: name: Wang, Yue
name: Jongman, Allard
name: Sereno, Joan A.
Publisher: name: Zenodo
Year: 1998

description: Auditory traInIng of nonnative speech contrasts is based on the assumption that the adult perceptual system can be modified. Previous research has shown substantial improvement in the identification of nonnative segmental distinctions after a simple phonetic laboratory training procedure. This study attempted to investigate whether such a procedure is applicable to the acquisition of nonnative suprasegmental contrasts, i.e., Mandarin tones. In four sessions during the course of a week, four American learners of Mandarin were trained to identify the four tones in natural words produced by both male and female native Mandarin talkers. The trainees' identification accuracy in the pretest and posttest were compared, showing an average 11% increase after training. This indicates that tone contrasts can be obtained and improved by training. The results are discussed in terms of nonnative perceptual modification at the suprasegmental level, as well as some methodological implications for further studies.
description: This paper is copyrighted, and is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) - see https://creativecommons.org/licenses/by-nc-nd/4.0/
Talking with the Dead and Walking in their Shadows - A conversation between Leonardo Da Vinci and Thomas ROSSI
Creators: name: ROSSI, Thomas
Publisher: name: figshare
Year: 2016
Subjects: subject: Design
subject: Ecology
subject: FOS: Biological sciences

description: Fictionnal conversation between the ghost of Leonardo Da Vinci and myself, about Ecology, Design and Complexity.
Hemispheric differences in grammatical class: A hemifield investigation
Creators: name: Sereno, Joan A.
Publisher: name: Zenodo
Year: 1998

description: Although a number of studies have examined lexical asymmetries in hemispheric processing, few have systematically investigated differences between nouns and verbs. Lateralization effects of grammatical class were examined by presenting nouns and verbs of both high and low frequencies to either the right or left visual field. Results from a noun/verb categorization task revealed a significant visual field by grammatical class interaction: Verbs were processed faster in the left compared to the right hemisphere, while there was no hemispheric advantage for the processing of nouns. The present study provides new evidence for the role of grammatical class in lexical processing. These behavioral results, in combination with imaging data from fMRI (Pugh et aI., 1997), suggest that lexical knowledge is organized so that representations of different grammatical categories are processed by different brain mechanisms.
description: This paper is copyrighted, and is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) - see https://creativecommons.org/licenses/by-nc-nd/4.0/
Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids
Creators: name: Sharma, Pramod K.
name: Sakshi Balwani
name: Mathur, Divya
name: Shashwat Malhotra
name: Brajendra K. Singh
name: Prasad, Ashok K.
name: Len, Christophe
name: Eycken, Erik V. Van Der
name: Balaram Ghosh
name: Richards, Nigel G. J.
name: Virinder S. Parmar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: New isatin-triazole based hybrids have been synthesized and evaluated for their inhibitory activity of TNF-α induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the surface of human endothelial cells. Structure-activity relationship (SAR) studies revealed that the presence of the electron-attracting bromo substituent at position-5 of the isatin moiety played an important role in enhancing the anti-inflammatory potential of the synthesized compounds. Z-1-[3-(1H-1,2,4-Triazol-1-yl)propyl]-5-bromo-3-[2-(4-methoxyphenyl)hydrazono]indolin-2-one (19) with an IC50 = 20 μM and 89% ICAM-1 inhibition with MTD at 200 μM was found to be the most potent of all the synthesized derivatives. Introduction of 1,2,4-triazole ring and electron-donating methoxy group on the phenylhydrazone moiety resulted in four-fold increase of the anti-inflammatory activity.
The Metrical Structure of Yindjibarndi ----Lenition, Trochees, and Vowel Coalescence
Creators: name: Lavoie, Lisa M.
Publisher: name: Zenodo
Year: 1998

description: Yindjibarndi, a Ngarluma language spoken in northwestern Australia, displays an intriguing pattern of stress in which all long vowels may be pronounced as a sequence of two short vowels. Previous analyses (Wordick 1982, Kager 1993) have treated this as vowel breaking, but I show that the language's morphology, historical and synchronic phonology, and metrical structure support an analysis in which identical adjacent short vowels coalesce into a single long vowel, but only where they can serve as the head of a foot. I construct an Optimality Theoretic account of these facts, drawing on numerous well-established constraint types including correspondence constraints (McCarthy & Prince 1995), positional faithfulness constraints (Beckman 1997), prosodic constraints (McCarthy & Prince 1993), and a version of the Weight to Stress Principle (Prince 1990). Additionally, I motivate a sociolinguistic constraint, *RUDE, which forces consonant lenition. In addition to accounting for the interactions of consonant loss, vowel length, and metrical structure without appealing to levels or rules that look ahead, Optimality Theory offers a vocabulary for the interaction of sociolinguistic and phonological constraints.
description: This paper is copyrighted, and is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) - see https://creativecommons.org/licenses/by-nc-nd/4.0/
The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine and their cytotoxicity against three human cancer cell lines
Creators: name: Kanok-On Rayanil
name: Cholthicha Prempree
name: Surachai Nimgirawath
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine have been achieved. The crucial step involved the formation of ring C by a microwave-assisted direct biaryl coupling to produce the aporphine skeleton in high yields. The synthetic alkaloids were evaluated for their cytotoxicity against three human cancer cell lines MCF7, KB and NCI-H187. The results showed that uthongine was the best candidate of the series and it exhibited cytotoxicity against a human breast cancer MCF7 line with an IC50 = 3.05 μM
An ALMA View of the Host Galaxies of Radio-Loud Quasars at z>5
Creators: name: Mazzucchelli, Chiara
name: Decarli, Roberto
name: Bañados, Eduardo
name: Khusanova, Yana
name: Rojas-Ruiz, Sofía
name: Farina, Emanuele Paolo
Publisher: name: Zenodo
Year: 2022

description: The last few years have seen a true Golden Age for the discovery and characterization of luminous quasars at the highest redshifts (z>5, within 1Gyr from the Big Bang, i.e. in the Epoch of Reionization); ~10% of such quasars are classified as radio-loud, i.e. they show powerful radio-jets. The interaction between these jets and the interstellar medium in their host galaxies is thought to play a crucial role in the supermassive black hole/galaxy (co-)evolution. However, very little have been known so far about this interaction at high-z, due to the lack of (sub)-mm observations of such radio-loud quasars.
 Here, we present new ALMA observations of the host galaxies of six radio-loud quasars at z>5, aimed at recovering their dust emission and their [CII] emission line in the rest-frame far-infrared. We show that these galaxies already host large dust reservoirs and are forming stars at rates>~30 Msun/yrs. We compare their far-infrared and [CII] emission line properties with those of radio-quiet quasars at comparable redshifts, in order to highlight any potential star formation enhancement/suppression from the radio jets. Lastly, we search for potential gas-rich galaxies surrounding these radio-loud quasars, as expected from theoretical predictions.
Towards LSDCat2.0: An improved algorithm for detecting emission line sources in integral-field spectroscopic datasets
Creators: name: Herenz, Edmund Christian
Publisher: name: Zenodo
Year: 2022
Subjects: astronomy
software
source detection

description: LSDCat is a software for detecting emission-line sources in 3D integral-field spectroscopic (IFS) data. It has been used effectively on MUSE and KCWI cubes and it is an essential part of the MUSE-Wide survey data processing pipeline. Its algorithm is based upon a slightly simplified matched-filter ansatz. It provides optimal detection significances under the assumption of stationary noise. However, the high frequency and high amplitude noise background from the "forest" of telluric OH Meinel bands at longer wavelengths invalidate this assumption. Thus detection significances for emission-line sources falling on or in between sky-lines are biased low. We here present an improved algorithm that remedies this shortcoming. The improvement will be part of an updated LSDCat2.0. It will benefit especially the detection of \(z \gtrsim 5\) Lyman-alpha emitters in the deepest MUSE data, e.g., in the 140h MUSE eXtreme deep field.
Yuhania: a unique angiosperm from the Middle Jurassic of Inner Mongolia, China
Creators: name: Liu, Zhong-Jian
name: Wang, Xin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Despite increasing claims of pre-Cretaceous angiosperms, whether there really are angiosperms in the Jurassic is apparently still an open question for many people before further evidence is available. This question can only be answered by studying more Jurassic plant fossils. Here we report a fossil angiosperm, Yuhania daohugouensis gen. et sp. nov, from the Middle Jurassic of Inner Mongolia, China. The plant includes connected stem, leaves, flowers, aggregate fruits, fruitlets, and seeds within fruitlets. The leaves are helically arranged along the curving stem, linear in shape, with 5–6 parallel veins. The aggregate fruit is pedicellate, composed of over 20 carpels/fruitlets helically arranged. Each fruitlet encloses a seed. The reproductive organs in various stages are found in the same plant, allowing us to understand the development of Yuhania. The occurrence of Yuhania in the Middle Jurassic re-confirms the Jurassic history for angiosperms that has been suggested by other independent research and adds to the on-going study on the early evolution of angiosperms.
Bicyclic N-heterocyclic carbene (NHC) ligand precursors and their palladium complexes
Creators: name: Gümüşada, Rukiye
name: M. Emin Günay
name: Namık Özdemir
name: Çetinkaya, Bekir
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Eight bicyclic amidinium precursors (3), prepared from R,S-tmcp (R,S-tmcp: (1R,3S)-diamino-1,2,2-trimethylcyclopentane) were described. Only five of the precursors (3a–e) could be converted to palladium complexes, (PdX2(6,7-NHC)PEPPSI) (4) by treatment with PdCl2, K2CO3, and pyridine (additional KBr was used for (PdBr2(6,7-NHC)PEPPSI)). The salts and complexes were fully characterized by spectroscopic methods and X-ray crystallography.
Testimony of George Greer, M.D. in DEA Hearing on Scheduling MDMA Under the Controlled Substances Act. in the Matter of MDMA Scheduling Item
Creators: name: Greer, George
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 480701
subject: Administrative law
classificationCode: 500104
subject: Human rights and justice issues (excl. law)

description: Testimony of George Greer, M.D. in DEA Hearing on Scheduling MDMA Under the Controlled Substances Act. in the Matter of MDMA Scheduling. Docket No. 84-48. United States Department of Justice, Drug Enforcement Administration.
Physiological response of Miscanthus genotypes to salinity stress under elevated CO2
Creators: name: Liang, Kehao
name: Peng, Xiaoying
name: Liu, Fulai
Publisher: name: figshare
Year: 2022
Subjects: subject: 70302 Agronomy
subject: FOS: Agriculture, forestry and fisheries

description: Miscanthus is a class of C4 perennial grasses, which can be cultivated on marginal land even with high salinity. However, the future environment may be altered by elevated atmospheric CO2 concentration ([CO2]) and knowledge is limited about the interactive impacts of CO2 enrichment and salinity on this C4 bioenergy crop. In this study, three Miscanthus genotypes (M. sacchariflorus, M.× giganteus, and M. lutarioriparius) were grown under either ambient (400 ppm) [CO2] (a[CO2]) or elevated (800 ppm) [CO2] (e[CO2]) at five salinity levels (0, 50, 100,150 and 200 mM NaCl denoted as S0, S1, S2, S3, S4, respectively), and the impacts of e[CO2] on plant physiological responses to salt stress were investigated. Our results suggested that e[CO2] had no obvious effect on net photosynthetic rate (An), but significantly reduced the stomatal conductance (gs), thus improving water use efficiency regardless of salinity levels. In addition, e[CO2] could improve water potential of plants under both control and saline conditions, but the magnitude of increase was highly genotypic dependent. The maximum quantum yield of photosystem II (Fv/Fm) was not altered by e[CO2], which, however, could alleviate the negative effect of salt on Fv/Fm. Furthermore, salt stress increased the concentration of ABA in xylem sap and leaves, while the effect of e[CO2] on ABA level was closely associated with genotypes. e[CO2] reduced Na+ concentration and had positive influences on maintaining Na+/K+ ratio, thus favoring ionic homeostasis, though such effect was genotype-dependent. Collectively, our data suggested that e[CO2] could partially mitigate the detrimental effects of salinity, conferring higher salt tolerance of Miscanthus.
title: Novel Mantle flow retrodictions reveal preferential material flow in the sublithospheric European mantle
Creators: name:  Bunge,   Hans-Peter
name:  Ghelichkhan ,   Siavash
name:  Oeser ,   Jens
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The Cenozoic tectonic evolution of Northern Europe involves a number of events that are difficult to reconcile with an intra-plate setting, including magmatic events and topographic changes that are located far from plate boundaries. It is entirely plausible to relate these events to sublithospheric processes in a vigorously convecting mantle. However, traditional mantle convection models are difficult to link to the spatiotemporal constraints provided by geologic archives, because their output invariably depends on the assumptions of poorly known and arbitrary initial conditions. Here we explore a new class of time-dependent global geodynamic Earth models, known as retrodictions, which are based on inverse approach to reconstruct past mantle flow and structure. Our high resolution, compressible, global mantle ﬂow retrodictions involve more than 670 million finite elements. Going back 50 million years ago they reveal a preferential flow direction in the sub-European mantle related to material influx from the North Atlantic realm. The retrodictions allow us to track material back in time from any given sampling location, making them potentially useful, for example, to geochemical studies. Our results call for improved estimates on non-isostatic vertical motion of the Earth’s surface – provided, for instance, by basin analysis, seismic stratigraphy, landform studies, thermochronological data, or the sedimentation record – to constrain the recent mantle ﬂow history beneath northern Europe and suggest that mantle ﬂow retrodictions may yield powerful synergies across diﬀerent Earth sciences disciplines.
Resynchronising returns to service in anoestrous dairy cows in the South Island of New Zealand
Creators: name: AJ Bates
name: AG Kenyon
name: RA Laven
name: JC McDowell
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: AIMS: To investigate the effect of targeted resynchronisation of cows treated for non-observed oestrus before the planned start of mating (PSM), that were not detected in oestrus or pregnant 23 days after treatment (phantom cows), on the proportion pregnant at 42 days after PSM and the end of mating. METHODS: Farm staff from eight herds in two regions of the South Island of New Zealand identified 1,819 cows not showing oestrus by 10 days before PSM. These cows were treated with intravaginal progesterone for 7 days, and I/M gonadorelin 10 days and 1 day before PSM. Three days before PSM they were injected with cloprostenol and equine chorionic gonadotrophin, with fixed time artificial insemination (FTAI) at PSM. By 23 days after PSM, 1,218 cows had not returned to oestrus. Of these, 161 cows confirmed not pregnant by transrectal ultrasonography were randomly assigned to no treatment (control group; n=74) or were resynchronised 25 days after PSM using the same treatment programme as above, with FTAI 35 days after PSM (n=87). All cows that returned to oestrus were artificially inseminated until 42 days after PSM, when natural mating was used. All cows were examined using transrectal ultrasonography 80 to 90 days after PSM to confirm conception dates. RESULTS: Of the 1,819 anoestrous cows treated before PSM, 526 (29 (95% CI=23.1–34.0)%) had not been observed in oestrus by 23 days after PSM and had not conceived, so were diagnosed as phantoms cows. For resynchronised cows, 42/87 (48 (95% CI=37.8–58.8)%) were pregnant by 42 days after PSM compared to 21/74 (28 (95% CI=18.1–38.7)%) control cows (p=0.009). At the end of mating 58/87 (67 (95% CI=56.6–76.7)%) cows in the resynchronised group were pregnant and 46/74 (62 (95% CI=50.9–73.2)%) in the control group (p=0.554). The hazard of conception from 21 to 42 days after PSM was 1.9 (95% CI=1.07–3.12) times greater for resynchronised than control cows (p=0.026). CONCLUSION: In cows not observed in oestrus and treated before PSM, resynchronisation increased the proportion pregnant by 42 days after PSM. CLINICAL RELEVANCE: The benefit of resynchronisation depends on the number of anoestrous cows before PSM and the number of phantom cows after PSM. However at the herd-level it is likely that providing advice to reduce the known risk factors for cows not being observed in oestrus before the PSM may well be more cost effective than identifying and treating a sub-population of phantom cows.
Doelgroepleerlingen in het basisonderwijs. Historische ontwikkeling en actuele situatie
Creators: name: Roeleveld, Jaap
name: Driesssen, Geert
name: Ledoux, Guuske
name: Cuppen, Joris
name: Meijer, Joost
Publisher: name: Kohnstamm Instituut
Year: 2011
Subjects: onderwijsachterstanden
COOL5-18
cohortonderzoek
sociaal milieu
etniciteit
prestaties
loopbanen

description: Sinds de jaren zeventig van de vorige eeuw wordt er door de Nederlandseoverheid beleid gevoerd terbestrijding van onderwijsachterstanden die het gevolg zijn van sociale,economische en culturele factoren. Om vast te stellen of er verbeteringoptreedt in de onderwijskansen van leerlingen die behoren tot de doelgroepenvan het achterstandenbeleid, wordt vanaf het schooljaar 1988/89 in hetbasisonderwijs en vanaf schooljaar 1989/90 in het voortgezet onderwijscohortonderzoek uitgevoerd. Tot 2005 ging het om het LEO- het PRIMAcohortonderzoekin het basisonderwijs en PRIMA-VO en VOCL in hetvoortgezet onderwijs. Daarna zijn deze cohorten geïntegreerd voortgezetonder de naam COOL5-18. Dankzij deze onderzoeken zijn er uitgebreidedatabestanden opgebouwd, die informatie bevatten over meerdereleerlingcohorten in verschillende fasen van de schoolloopbaan in basis- envoortgezet onderwijs. Deze zijn al vele malen benut voor onderzoek naar deontwikkeling van de prestaties en loopbanen van de doelgroepen van hetonderwijsachterstandenbeleid.Dit rapport bevat over dit onderwerp nieuwe gegevens, op basis van nieuweanalyses op de cohortdata, waaronder de meeste recente uit COOL5-18. Tweehoofdonderwerpen komen aan de orde. In de eerste plaats wordtgerapporteerd over verschillen in leerprestaties in het basisonderwijs tussen dedoelgroepen van het beleid en overige leerlingen, en over ontwikkelingendaarin in de tijd. In de tweede plaats wordt ingegaan op de vraag of er bijdoelgroepleerlingen meer dan bij andere leerlingen sprake is van onbenuttalent en van discrepanties tussen leerprestaties en het advies voor hetvoortgezet onderwijs.
A QUEM APROVEITA, AFINAL, A JUDICIALIZAÇÃO DE POLÍTICAS PÚBLICAS TENDENTES À CONCRETIZAÇÃO DE DIREITOS FUNDAMENTAIS SOCIAIS?
Creators: name: Ferreira, Daniel
name: TATIANA DENCZUK
Publisher: name: figshare
Year: 2016
Subjects: subject: Law
subject: FOS: Law

description: This article examines the judicialization of policies concerning public services and their beneficiaries. The social rights guaranteed by the Constitution include the provision of certain public services. But where the Constitution is silent or lacking in details, it creates the opportunity for the matters to be discussed in Court, requiring the appreciation of limitations to judicial intervention. These limitations include the principle of separation of powers, scarcity of resources and public budgets, as well as limits intrinsic to very nature of jurisdiction. The article also deals with the issue of unequal access to justice, with its cultural and economic factors, since the less privileged segments of the population may not have knowledge of their rights or may lack the financial resources to hire an attorney.
GOVERNANÇA AMBIENTAL INTERNACIONAL E SUSTENTABILIDADE.pdf
Creators: name: DANIEL RUBENS CENCI
name: ALINE ANDRIGHETTO
name: JAIME FERNANDO ESTENSSORO SAAVEDRA
Publisher: name: figshare
Year: 2016
Subjects: subject: Law
subject: FOS: Law

description: The nature and its life forms have significant importance due to the biomes found on the planet. The environmental debate presupposes a reflection on the current world, where it becomes important historical and biological evolution in the modern world. Regarding the issue governance has been the subject regarding the breadth of the issues surrounding the participation of actors whose interests are concerned in decision-making processes. The environmental issue becomes important area of governance, whether considered in a broad debate the ecologically balanced environment as a universal fundamental human right, including the participation of different actors. In this sense the text search, with a literature review, discuss environmental issues which defies borders to demand recognition of their ecological interdependence between global territories.
title: 03_0751
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
Creators: name: Sim, M F Michelle
name: Persiani, Elisa
name: Talukder, Md Mesbah Uddin
name: Mcilroy, George D
name: Roumane, Ahlima
name: Edwardson, J Michael
name: Rochford, Justin J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Seipin deficiency causes severe congenital generalized lipodystrophy (CGL) and metabolic disease. However, how seipin regulates adipocyte development and function remains incompletely understood. We previously showed that seipin acts as a scaffold protein for AGPAT2, whose disruption also causes CGL. More recently, seipin has been reported to promote adipogenesis by directly inhibiting GPAT3, leading to the suggestion that GPAT inhibitors could offer novel treatments for CGL. Here we investigated the interactions between seipin, GPAT3 and AGPAT2. We reveal that seipin and GPAT3 associate via direct interaction and that seipin can simultaneously bind GPAT3 and AGPAT2. Inhibiting the expression of seipin, AGPAT2 or GPAT3 led to impaired induction of early markers of adipocyte differentiation in cultured cells. However, consistent with normal adipose mass in GPAT3-null mice, GPAT3 inhibition did not prevent the formation of mature adipocytes. Nonetheless, loss of GPAT3 in seipin-deficient preadipocytes exacerbated the failure of adipogenesis in these cells. Thus, our data indicate that GPAT3 plays a modest positive role in adipogenesis and argue against the potential of GPAT inhibitors to rescue white adipose tissue mass in CGL2. Overall, our study reveals novel mechanistic insights regarding the molecular pathogenesis of severe lipodystrophy caused by mutations in either seipin or AGPAT2.
Oil and gas companies invest in legislators that vote against the environment.
Creators: name: Goldberg, Matthew H
name: Marlon, Jennifer R
name: Wang, Xinran
name: Van Der Linden, Sander
name: Leiserowitz, Anthony
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Climate change
Congress
Campaign Contributions
Antienvironment

description: Do campaign contributions from oil and gas companies influence legislators to vote against the environment, or do these companies invest in legislators that have a proven antienvironmental voting record? Using 28 y of campaign contribution data, we find that evidence consistently supports the investment hypothesis: The more a given member of Congress votes against environmental policies, the more contributions they receive from oil and gas companies supporting their reelection.
International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC).
Creators: name: Singh, Yogen
name: Tissot, Cecile
name: Fraga, María V
name: Yousef, Nadya
name: Cortes, Rafael Gonzalez
name: Lopez, Jorge
name: Sanchez-De-Toledo, Joan
name: Brierley, Joe
name: Colunga, Juan Mayordomo
name: Raffaj, Dusan
name: Da Cruz, Eduardo
name: Durand, Philippe
name: Kenderessy, Peter
name: Lang, Hans-Joerg
name: Nishisaki, Akira
name: Kneyber, Martin C
name: Tissieres, Pierre
name: Conlon, Thomas W
name: De Luca, Daniele
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Children
Neonate
ultrasound
Neonatal Intensive Care Unit (Nicu)
Paediatric Intensive Care Unit (Picu)
Point Of Care Ultrasound (Pocus)
Humans
Critical Illness
Ultrasonography
Critical Care
Intensive Care, Neonatal
Infant, Newborn
Intensive Care Units, Neonatal
Point-of-Care Systems
Systematic Reviews as Topic

description: BACKGROUND:Point-of-care ultrasound (POCUS) is nowadays an essential tool in critical care. Its role seems more important in neonates and children where other monitoring techniques may be unavailable. POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) aimed to provide evidence-based clinical guidelines for the use of POCUS in critically ill neonates and children. METHODS:Creation of an international Euro-American panel of paediatric and neonatal intensivists expert in POCUS and systematic review of relevant literature. A literature search was performed, and the level of evidence was assessed according to a GRADE method. Recommendations were developed through discussions managed following a Quaker-based consensus technique and evaluating appropriateness using a modified blind RAND/UCLA voting method. AGREE statement was followed to prepare this document. RESULTS:Panellists agreed on 39 out of 41 recommendations for the use of cardiac, lung, vascular, cerebral and abdominal POCUS in critically ill neonates and children. Recommendations were mostly (28 out of 39) based on moderate quality of evidence (B and C). CONCLUSIONS:Evidence-based guidelines for the use of POCUS in critically ill neonates and children are now available. They will be useful to optimise the use of POCUS, training programs and further research, which are urgently needed given the weak quality of evidence available.
Proteomics analysis of zebrafish brain following chronically exposed to bisphenol A
Creators: name: Xiangyang Wu
name: Chongwei Lu
name: Dong, Xing
name: Zhang, Zhen
name: Yang, Ming
name: Xu, Hai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Bisphenol A, a plastic monomer and plasticizer, is a well-known endocrine disrupter, widely present in the aquatic environment, but little is known regarding its neurotoxicity in fish. Herein, we investigated its effects on male zebrafish brain. Zebrafish were exposed to 10 µg/L BPA for 45 days. An isobaric tags for relative and absolute quantitation approach coupled with nano high-performance liquid chromatography-tandem mass spectrometry analysis was employed to detect and identify differentially expressed proteins. A total of 46 proteins was identified and categorized into functional classes that mostly included metabolism and transport, cytoplasm and organelle, ion and nucleotide binding, indicating that bisphenol A toxicity in fish brain is complex. The biological pathways of starch and sucrose metabolism, calcium signaling, and aminoacyl-tRNA biosynthesis were also induced. Proteomic analyses add new perspectives to bisphenol A neurotoxicity in aquatic organisms.
Testimony of Joseph J. Downing, M.D. in the Matter of MDMA Scheduling
Creators: name: Downing, Joseph
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 480701
subject: Administrative law
classificationCode: 500104
subject: Human rights and justice issues (excl. law)

description: Testimony of Joseph J. Downing, M.D. in the Matter of MDMA Scheduling. Docket No. 84-48. United States Department of Justice, Drug Enforcement Administration.
Carnet nº 14, commencé à Omuta (p. 52)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 15-11-1930
Car-sharing: The impact on metropolitan spatial structures
Creators: name: Smolnicki, Piotr Marek
name: Sołtys, Jacek
Publisher: name: figshare
Year: 2017
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Many examples from the past show that new technologies designed to solve particular problems can also create side effects generating new problems. Some unforeseen or unwanted results may influence space use and spatial structures. Car-sharing is an invention to compete with car ownership. It drastically rise efficiency of car use, reducing the number of vehicles per users. Diffusion of car-sharing is going to accelerate in the near future. The spatial consequences of the car-ownership-oriented-century are already known. But things can complicate if everybody could join traffic with shared automobiles. It is therefore appropriate to anticipate potential side effects of this innovation’s diffusion to avoid negative consequences, and if necessary – to prepare to encounter them. This led to undertake research on the relationship between modern mobility innovations and metropolitan spatial structures. The earliest implementations of new transport technologies appear in metropolises which also have the highest level of general mobility. The article presents the assumptions and principles of scenario-based research. The example shows how diffusion of innovation determine possible scenarios of the future impacts of car-sharing on spatial structures.
Aquaponics Based Artificial Biosphere Included In Architecture: From Mitigation of Negative Impacts to Positive Added Values of Urban Spatial Structures on Local, Regional and Global Scale
Creators: name: Smolnicki, Piotr Marek
Publisher: name: figshare
Year: 2016
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Technologies may appear faster than spatial planning can afford it. Although applying new technologies solve particular problems, it may also create new ones. Many negative consequences of implementing new technologies are visible after years or decades – they accumulate until the need of solving them. According to The Hannover Principles (McDonough & Braungart 2013) one should, by example not think about reducing but about eliminating negative impacts. Did we learn life-cycle management from this since 1992, and implement it correctly? Can we predict and eliminate negative side effects? Could we add a positive value to the neighbourhood? In this paper author will scrutinize selected applications of modern and contemporary techniques and technologies influencing shaping of spatial structures and will emphasize their side effects in terms of urban, regional and global “health”. Author will propose contemporary local intervention and investment possibilities on creating self-sustaining neighbourhoods and buildings. Its background will be a new vision of architecture and spatial structures that include ideas inspired from biosphere, e.g.: retrieving and capturing or circulation of CO2 and nutrients. Author will present a concept based on aquaponics gardening that could be adapted to existing buildings and new designs. The concept design will not only reduce and eliminate emissions but also could have a positive impact on citizens’ health and the whole city and its surrounding.
Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study.
Creators: name: Yuan, Shuai
name: Carter, Paul
name: Vithayathil, Mathew
name: Kar, Siddhartha
name: Giovannucci, Edward
name: Mason, Amy M
name: Burgess, Stephen
name: Larsson, Susanna C
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Iron
Ferritin
Cancer
Serum transferrin
Transferrin Saturation
Mendelian Randomization

description: We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a genome-wide association study of 48,972 European-descent individuals. Summary-level data for breast and other cancers were obtained from the Breast Cancer Association Consortium and UK Biobank. Genetically predicted iron status was positively associated with liver cancer and inversely associated with brain cancer but not associated with overall cancer or the other 20 studied cancer sites at p < 0.05. The odds ratios of liver cancer were 2.45 (95% CI, 0.81, 7.45; p = 0.11), 2.11 (1.16, 3.83; p = 0.02), 10.89 (2.44, 48.59; p = 0.002) and 0.30 (0.17, 0.53; p = 2 × 10-5) for one standard deviation increment of serum iron, transferrin saturation, ferritin and transferrin levels, respectively. For brain cancer, the corresponding odds ratios were 0.69 (0.48, 1.00; p = 0.05), 0.75 (0.59, 0.97; p = 0.03), 0.41 (0.20, 0.88; p = 0.02) and 1.49 (1.04, 2.14; p = 0.03). Genetically high iron status was positively associated with liver cancer and inversely associated with brain cancer.
Variability of recurrence interval and single-event slip for surface-rupturing earthquakes in New Zealand
Creators: name: A Nicol
name: R Robinson
name: RJ Van Dissen
name: A Harvison
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Recurrence interval (RI) and single-event slip (SES) for large-magnitude earthquakes that ruptured the ground surface (Mw > 6–7.2) can vary by more than an order of magnitude on individual faults. Frequency histograms, probability density functions (PDFs) and coefficient of variation (Cv, standard deviation/arithmetic mean) values for geological and simulated earthquakes on over 100 New Zealand active faults have been used to quantify RI and SES variability. Histograms of RI and SES for geological paleoearthquakes were constructed using a Monte Carlo method which accounts for the observations and their uncertainties. For the best of the geological PDFs (i.e. ≥7 surface-rupturing events) and earthquake simulations, RI are positively skewed with long recurrence tails (c. three times the mean) which are approximately described by log-normal and Weibull distributions. The geometric mean and coefficient of variation (Cvln) calculated for these log-normal distributions may be up to a factor of two lower and higher, respectively, than those determined assuming a normal distribution. By contrast, SES for geological and simulated earthquakes is often approximately normally distributed and appears to be less variable than RI (RI Cv 0.6 ± 0.2 geological and 0.6 ± 0.3 simulations; SES Cv 0.4 ± 0.2 geological). Variations in earthquake RI and to a lesser extent SES produce order-of-magnitude changes in slip rate over time intervals up to five times the arithmetic mean RI. Quantifying variability of RI, SES and slip rates is important when producing estimates of seismic hazard for surface-rupturing earthquakes, and could be estimated for active faults with poorly constrained paleoearthquake histories using the PDFs presented here.
New Zealand GPS velocity field: 1995–2013
Creators: name: Beavan, John
name: Wallace, Laura M
name: Palmer, Neville
name: Denys, Paul
name: Ellis, Susan
name: Fournier, Nico
name: Hreinsdottir, Sigrun
name: Pearson, Christopher
name: Denham, Mike
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We collate nearly two decades of campaign GPS data gathered at over 900 sites throughout New Zealand to release a New Zealand nationwide GPS velocity field. The data span the entire North and South islands of New Zealand with a typical spacing of 10–20 km and a denser network (c. 2–8 km spacing) in the Wellington region, central Taupo Volcanic Zone and parts of the Arthur's Pass area. The dataset provides the most comprehensive-to-date view of crustal deformation within the Australia–Pacific plate boundary zone in the New Zealand region. We discuss the data acquisition, processing and derivation of the velocities and uncertainties. We also undertake corrections for earthquake displacements to obtain a velocity field that is largely representative of interseismic deformation between 1995 and 2013.
Transactions of the Digital Games Research Association -- Vol. 4, No. 1
Creators: name: Beavers, Sian
name: JAYEMANNE, DARSHANA
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 470102
subject: Communication technology and digital media studies

description: Diversity Workshop Special Issue
1. Facilitating Diversity-Centred Adult Computing Education Danielle Johnstone & Caroline Pelletier
2. Character Diversity in Digital and Non-Digital Games Alexandra To, Joselyn McDonald, Jarrek Holmes, Geoff Kaufman, & Jessica Hammer
3. Homo Includens: Surveying DiGRA’s DiversityMahli-Ann Rakkomkaew Butt, Lars de Wildt,Rachel Kowert, & Alyea Sandovar
4. DiGRA Chapter Diversity Hanna Wirman
title: Open-source and open data: combining both worlds for optimised decision making in geological subsurface models
Creators: name:  Wellmann ,   Florian
name:  de la Varga ,   Miguel
name:  Jüstel ,   Alexander
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Computational Geoscience and Reservoir Engineering (CGRE), RWTH Aachen University, Aachen, Germany(1);Terranigma Solutions GmbH, Aachen, Germany(2);Fraunhofer IEG, Fraunhofer Research Institution for Energy Infrastructures and Geothermal Systems, Am Hochschulcampus 1, 44801 Bochum, Germany(3);