title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼Ð°ÑÑÐ¸ÑÑ Ð´Ð»Ñ ÑÑÐ°Ð½ÑÐ´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Creation of the matrix for transdermal therapeutic system
Creators: name: Ð§ÐµÑÐºÐ°Ñ, ÐÐ»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÑÐ°Ð½ÑÐ´ÐµÑÐ¼Ð°Ð»ÑÐ½ÑÐµ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ
ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð°Ð½ÑÐ°Ð³Ð¾Ð½Ð¸ÑÑÑ Ð¾Ð¿Ð¸Ð¾Ð¸Ð´Ð½ÑÑ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð²
Ð½Ð°Ð»ÑÑÐµÐºÑÐ¾Ð½
transdermal therapeutic system
electrospinning
opioid antagonist
naltrexon

description: ÐÐ° 73 Ñ., 13 ÑÐ°Ð±Ð»., 24 ÑÐ¸Ñ., 8 ÑÐ¾ÑÐ¼ÑÐ» Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼Ð°ÑÑÐ¸ÑÑ Ð´Ð»Ñ ÑÑÐ°Ð½ÑÐ´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼ÑÂ». ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¼Ð°ÑÑÐ¸ÑÑ Ð´Ð»Ñ ÑÑÐ°Ð½ÑÐ´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð°Ð½ÑÐ°Ð³Ð¾Ð½Ð¸ÑÑÐ¾Ð² Ð¾Ð¿Ð¸Ð¾Ð¸Ð´Ð½ÑÑ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ñ. ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: 1. Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÐ°Ð±Ð¾ÑÐµÐ¹ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ ÑÐ¾ÑÐ¼Ð¾Ð²Ð¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ°ÑÑÐ²Ð¾ÑÐ°; 2. Ð¿Ð¾Ð´Ð±Ð¾Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ñ; 3. Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð½Ð°Ð»ÑÑÐµÐºÑÐ¾Ð½Ð° Ð² Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ½Ð¸ÑÑÑÑ Ð¼Ð°ÑÑÐ¸ÑÑ; 4. Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ðµ Ð¼Ð°ÑÑÐ¸Ñ Ð½Ð° ÑÐºÐ¾ÑÐ¾ÑÑÑ Ð²ÑÑÐ²Ð¾Ð±Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð½Ð°Ð»ÑÑÐµÐºÑÐ¾Ð½Ð°. ÐÐ±ÑÐµÐºÑÐ°Ð¼Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÑÑÑÑ Ð¼Ð°ÑÑÐ¸ÑÑ Ð´Ð»Ñ ÑÑÐ°Ð½ÑÐ´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ, Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð½ÑÐµ Ð¸Ð· Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÑ ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¹ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð ÑÐ¾Ð´Ðµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð² ÑÐ¾Ð·Ð´Ð°Ð½Ð° Ð¼Ð°ÑÑÐ¸ÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð½Ð°Ð½Ð¾Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ð¸Ð· Ð¿Ð¾Ð»Ð¸Ð»Ð°ÐºÑÐ¸Ð´Ð°. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½ Ð¿ÑÐ¾ÑÐ¸Ð»Ñ ÑÐºÐ¾ÑÐ¾ÑÑÐ¸ Ð²ÑÑÐ²Ð¾Ð±Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð½Ð°Ð»ÑÑÐµÐºÑÐ¾Ð½Ð° Ð¸Ð· Ð¼Ð°ÑÑÐ¸ÑÑ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ»Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¼Ð°ÑÑÐ¸ÑÑ Ñ Ð½Ð°Ð»ÑÑÐµÐºÑÐ¾Ð½Ð¾Ð¼, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð¼Ð¾Ð¶ÐµÑ Ð¿Ð¾ÑÐ»ÑÐ¶Ð¸ÑÑ Ð¾ÑÐ½Ð¾Ð²Ð¾Ð¹ Ð´Ð»Ñ Ð¿ÑÐ¾Ð¼ÑÑÐ»ÐµÐ½Ð½Ð¾Ð¹ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÑÑÐ°Ð½ÑÐ´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÑÐµÐ´ÑÑÐ².
description: 73 pages, 13 tables, 24 figures, 8 formulas Theme of the graduate qualification work is Â«Preparation of matrix for transdermal therapeutic systemÂ» This work is devoted to the creation of the matrix for transdermal drug delivery system of opioid antagonists on basis nanofibers preparation electrospinning method. The research set the following tasks: 1. Defined concentration of spinning solution. 2. Selection of technological parameters of electrospinning. 3. Drug loading in the matrix of nanofibers. 4. In vitro drug release. During the experiments, a matrix based on polylactide nanofibres was created. The profile of the rate of release of naltrexone from the matrix was studied. As a result, a technology to obtain the matrix with naltrexon was developed, which can serve as the basis for the industrial development of a transdermal system drug delivery.