cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Continuity of care among patients newly initiated on second-generation oral or long-acting injectable antipsychotics during a schizophrenia-related inpatient stay
Creators: name: Patel, Charmi
name: Pilon, Dominic
name: Morrison, Laura
name: Holiday, Christopher
name: Lafeuille, Marie-Hélène
name: Lefebvre, Patrick
name: Benson, Carmela
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Maintaining continuity of care after schizophrenia-related hospitalization is challenging for patients and healthcare providers and systems. Prior evidence suggests that second-generation long-acting injectable antipsychotics (SGLAIs) may reduce the risk of treatment nonadherence and readmission versus oral atypical antipsychotics (OAAs). Therefore, quality measures were compared between patients initiated on SGLAIs and OAAs in the United States. Adults newly initiated on an SGLAI or OAA during a schizophrenia-related inpatient stay were identified in HealthVerity databases (01/2015–12/2020); the index date was the hospital discharge date. Patients had continuous health insurance coverage for pharmacy and medical services for 6 months pre-admission and post-discharge from the inpatient stay and ≥1 pharmacy or medical claim (i.e. treatment as indicated by the observed insurance claims) for an antipsychotic other than the index SGLAI or OAA in the 6 months pre-admission. Antipsychotic use and adherence, and schizophrenia-related readmissions and outpatient visits were compared during the 6-month period post-discharge. Characteristics between cohorts were balanced using inverse probability weights. Post-discharge, only 36.9% and 40.7% of weighted SGLAI (N = 466) and OAA (N = 517) patients had ≥1 pharmacy or medical claim for the antipsychotic initiated during the inpatient stay, among whom SGLAI patients were 4.4 times more likely to be adherent to that antipsychotic compared to OAA patients (p < .001). Additionally, SGLAI patients were 2.3 and 3.0 times more likely to have a pharmacy or medical claim for and be adherent to any antipsychotic relative to OAA patients (including index antipsychotic; all p < .001). Within 7 and 30 days post-discharge, 1.7% and 13.0% of SGLAI patients and 4.1% and 12.6% of OAA patients had a readmission. Further, SGLAI patients were 51% more likely to have an outpatient visit compared to OAA patients (p = .044). Less than half of patients initiated on antipsychotics during a schizophrenia-related inpatient stay continued the same treatment post-discharge. However, SGLAI patients were more likely to be adherent to the initiated antipsychotic and to have an outpatient visit, which may suggest improved continuity of care post-discharge relative to OAA patients.
Systems analysis of the spatial regulation of oncogenic Ras signalling
Creators: name: Heinelt, Kaatje Friederike
Publisher: name: Technische Universität Dortmund
Year: 2017
Subjects: subject: (K)Ras
subject: Relocalization
subject: PDEδ
subject: Deltarasin
subject: Deltazinone 1
subject: 570

description: Ras (Rat sarcoma) isoforms are small GTP-binding proteins that play a major role in the signalling networks controlling cell growth and survival. The Kras isoform is of particular interest as in many severe kinds of cancer the presence of oncogenic Kras mutations is associated with a poor prognosis. Kras is associated with the plasma membrane due to its farnesyl moiety and a polybasic motif and functions as a signalling hub. If Kras gets lost from the plasma membrane due to spontaneous dissociation or endocytosis, it will equilibrate over the extensive endomembrane system inside the cell. With Kras no longer present at the plasma membrane, its activation and the following activation of subsequent pathways can no longer take place. However, to remain on the plasma membrane, Kras has to be constantly enriched there. This enrichment must be actively maintained in the cell by an energy-driven mechanism involving the solubilising factor PDEδ. Consequently, inhibition or down-modulation of PDEδ results in mislocalisation of Kras, making PDEδ an interesting target for anti-cancer drug development. In 2013 a small molecule, Deltarasin, was identified as a potent inhibitor of PDEδ causing a redistribution of Kras from the plasma membrane towards endomembranes when applied to cells. This work investigates whether small molecule PDEδ inhibitors such as Deltarasin affect (K) Ras localization in space and time. It demonstrates that PDEδ inhibition causes Ras relocalisation from the plasma membrane towards the endomembranes in different human cancer cell lines and in murine small intestine organoids, which express endogenous levels of oncogenic Kras. Nonetheless, it has been shown that Deltarasin has certain side effects, e.g. it becomes cytotoxic at higher concentrations. Hence, a new PDEδ inhibitor, Deltazinone 1, which is supposed to be less cytotoxic in comparison to Deltarasin, was synthesized. In order to determine whether it represents a viable alternative to Deltarasin, its ability to relocalise Kras in a panel of cancer cell lines was tested and it was indeed possible to mislocalise Kras with this inhibitor in Kras-dependent PancTuI cells. Deltazinone 1 and Deltarasin both had a demonstrable effect on cell growth/survival, respectively. In this way it appears that PDEδ constitutes a valid target for the pharmacological therapy of Kras-dependent tumours. This work demonstrates that two specific PDEδ inhibitors with completely different lead structures are capable of mislocalising Kras to endomembranes. In sum, it demonstrates that the availability of PDEδ is essential to ensure (K) Ras localization at the plasma membrane in Kras-dependent cancer cells and thus that the survival of those cells are ultimately dependent on PDEδ.
Cancer incidence and mortality trends in Asia based on regions and human development index levels: an analyses from GLOBOCAN 2020
Creators: name: Rajappa, Senthil
name: Singh, Manmohan
name: Uehara, Roberto
name: Schachterle, Stephen E.
name: Setia, Sajita
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Science Policy
Computational Biology

description: As Asian countries transition socially and economically to higher Human Development Index (HDI) levels, cancer trends are expected to shift to those seen in the Western World. A strong correlation also exists between HDI levels and age-standardized rates (ASR) for the incidence and mortality of cancer. However, there are very few reports on the trends in Asian countries, particularly in Low and Middle-Income Countries (LMICs). In this study, we have investigated the relationship between socioeconomic developments in Asia (determined using HDI levels of countries) and cancer incidence and mortality in these nations. The GLOBOCAN 2020 database was used to study the cancer incidence and mortality data for all cancers combined and those most commonly diagnosed in Asia. The difference in data was analyzed based on region and HDI level. Further, the predictions for cancer incidence and mortality in 2040 according to the GLOBOCAN 2020 were analyzed using the updated HDI stratification described in the UNDP 2020 report. Asia has the highest cancer burden compared to the other regions worldwide. Lung cancer carries the highest cancer incidence and mortality rates in the region. Inequitable distribution of cancer incidence and mortality is seen across regions and HDI levels in Asia. Inequalities in cancer incidence and mortality can only be expected to increase unless innovative and cost-effective interventions are urgently implemented. An effective cancer management plan is needed in Asia, particularly in LMICs, prioritizing effective cancer prevention and control measures for health systems.
Semaglutide versus tirzepatide for people with type 2 diabetes: cost of glycemic control in Austria, the Netherlands, Lithuania, and the United Arab Emirates
Creators: name: Reitzel, Signe Baattrup
name: Bøgelund, Mette
name: Basse, Amaury
name: Barszczewska, Olga
name: Ren, Hongye
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The glucagon-like peptide-1 agonist semaglutide and the dual glucose-dependent insulinotropic polypeptide tirzepatide have proven to significantly reduce glucose levels in people with type 2 diabetes. However, the costs needed to achieve a sustained decrease in HbA1c level and disease control with semaglutide and tirzepatide, respectively, are unclear. Therefore, this study aimed to compare the cost of treatment with semaglutide with the cost of treatment with tirzepatide for type 2 diabetes in Austria, the Netherlands, Lithuania, and the United Arab Emirates in order to determine their respective value for money. The primary outcome of this analysis was the cost in euros needed to achieve disease control in one person with type 2 diabetes based on the composite endpoint of HbA1c <7%, ≥5% weight loss, and no hypoglycemic events. In addition, analyses regarding the cost needed to reach relevant HbA1c endpoints were performed. Clinical data were obtained from the SURPASS 2 trial, registered at clinicaltrials.gov (NCT03987919), and drug cost was based on wholesale acquisition cost or pharmacy purchase prices from public domains obtained in Q1 of 2023. The cost needed to achieve disease control in one person with type 2 diabetes (HbA1c <7%, ≥5% weight loss, and no hypoglycemic events) was up to three times lower using semaglutide compared with all three doses of tirzepatide in most markets. In the HbA1c analyses, semaglutide was also found to be the least expensive treatment option. Semaglutide provides better value for money than tirzepatide for HbA1c-lowering endpoints.
Reconstruction of the Higgs mass in events with Higgs bosons decaying into a pair of tau leptons using matrix element techniques
Creators: name: Bianchini, L.
name: Calpas, B.
name: Conway, J.
name: Fowlie, A.
name: Marzola, L.
name: Perrini, L.
name: Veelken, C.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present an algorithm for the reconstruction of the Higgs mass in events with Higgs bosons decaying into a pair of tau leptons. The algorithm is based on matrix element (ME) techniques and achieves a relative resolution on the Higgs boson mass of typically 15-20%. A previous version of the algorithm has been used in analyses of Higgs boson production performed by the CMS collaboration during LHC Run 1. The algorithm is described in detail and its performance on simulated events is assessed. The development of techniques to handle tau decays in the ME formalism represents an important result of this paper.
description: 53 pages, 17 Figures
Semaglutide versus tirzepatide for people with type 2 diabetes: cost of glycemic control in Austria, the Netherlands, Lithuania and the United Arab Emirates
Creators: name: Reitzel, Signe Baattrup
name: Bøgelund, Mette
name: Basse, Amaury
name: Barszczewska, Olga
name: Ren, Hongye
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Cancer
Science Policy

description: Objectives: The glucagon-like peptide-1 agonist semaglutide and the dual glucose-dependent insulinotropic polypeptide tirzepatide have proven to significantly reduce glucose levels in people with type 2 diabetes. However, the costs needed to achieve a sustained decrease in HbA1c level and disease control with semaglutide and tirzepatide, respectively, are unclear. Therefore, this study aimed to compare the cost of treatment with semaglutide with the cost of treatment with tirzepatide for type 2 diabetes in Austria, the Netherlands, Lithuania and the United Arab Emirates in order to determine their respective value for money. Methods: The primary outcome of this analysis was the cost in euros needed to achieve disease control in one person with type 2 diabetes based on the composite endpoint of HbA1c <7%, ≥5% weight loss and no hypoglycemic events. In addition, analyses regarding the cost needed to reach relevant HbA1c endpoints were performed. Clinical data were obtained from the SURPASS 2 trial, registered at clinicaltrials.gov (NCT03987919), and drug cost was based on wholesale acquisition cost or pharmacy purchase prices from public domains obtained in Q1 of 2023. Results: The cost needed to achieve disease control in one person with type 2 diabetes (HbA1c <7%, ≥5% weight loss and no hypoglycemic events) was up to three times lower using semaglutide compared with all three doses of tirzepatide in most markets. In the HbA1c analyses, semaglutide was also found to be the least expensive treatment option. Conclusion: Semaglutide provides better value for money than tirzepatide for HbA1c-lowering endpoints.
Prescription opioid utilization patterns, and associated outcomes, among privately insured patients prescribed opioids to manage pain associated with osteoarthritis
Creators: name: Schepman, Patricia
name: Rice, J. Bradford
name: Beck, Craig G.
name: White, Alan
name: Robinson, Rebecca L.
name: Thakkar, Sheena
name: Fernan, Catherine
name: Emir, Birol
name: Silverman, Stuart
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: To describe utilization patterns, negative clinical outcomes and economic burden of patients diagnosed with osteoarthritis (OA) of the hip and/or knee who received a prescription for tramadol or non-tramadol opioids vs. non-opioid drugs. Optum Healthcare Solutions, Inc. commercial claims data were used (1/2012--3/2017). Adults with ≥2 diagnoses of OA of the hip and/or knee, and ≥30 days supply of pain medications were identified during the three-year period from the date of first prescription (index date) after the first OA diagnosis. Drug utilization statistics in the follow-up period were summarized by initial treatment (i.e. tramadol, non-tramadol opioids, non-opioid drugs). Opioid initiators were matched to those initiated on non-opioid treatments using a propensity score model accounting for baseline characteristics. Matched pairs analysis compared outcomes for these cohorts. Of 62,715 total patients, 15,270 (24.3%) initiated treatment with opioids, including 3,513 (5.6%) on tramadol and 11,757 (18.7%) on non-tramadol opioids. Opioid initiators had more comorbidities, higher baseline healthcare costs, and were more likely to have OA of the hip. Among non-opioid initiators, 27.5% switched to tramadol and 63% switched to non-tramadol opioids. Among tramadol initiators, 71% switched to non-tramadol opioids. Patients initiated on opioids had 20.4% (p < .01) higher all-cause healthcare costs and higher percentages experiencing multiple negative clinical outcomes (all p < .01) compared to matched controls. Most patients with OA of the hip and/or knee either initiate on or switch to opioids for long-term management of OA-related pain despite known risks. This highlights the need for new treatments that delay or prevent use of opioids.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 20 (6)]
Creators: name: , Petrus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1341
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Geringer Textverlust durch Beschädigung am oberen linken Rand
Conformal Patterson-Walker metrics
Creators: name: Hammerl, Matthias
name: Sagerschnig, Katja
name: Šilhan, Josef
name: Taghavi-Chabert, Arman
name: Žádník, Vojtěch
Publisher: name: arXiv
Year: 2016
Subjects: subject: Differential Geometry (math.DG)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 53A20, 53A30, 53B30, 53C07, 53C50

description: The classical Patterson-Walker construction of a split-signature (pseudo-)Riemannian structure from a given torsion-free affine connection is generalized to a construction of a split-signature conformal structure from a given projective class of connections. A characterization of the induced structures is obtained. We achieve a complete description of Einstein metrics in the conformal class formed by the Patterson-Walker metric. Finally, we describe all symmetries of the conformal Patterson-Walker metric. In both cases we obtain descriptions in terms of geometric data on the original structure.
description: v2: The article has been restructured: a section has been added and includes a characterisation of Patterson-Walker metrics. An error in Proposition 6.6 has been fixed v3: One reference clarified. v4: References added. Remark 6.9 added. Accepted for publication in The Asian Journal of Mathematics on 21 June 2018 v5: Minor changes, as published
Access and real-world use patterns of esketamine nasal spray among patients with treatment-resistant depression covered by private or public insurance
Creators: name: Teeple, Amanda
name: Zhdanava, Maryia
name: Pilon, Dominic
name: Caron-Lapointe, Gabrielle
name: Lefebvre, Patrick
name: Joshi, Kruti
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: To describe access and real-world use patterns of esketamine nasal spray among adults with treatment-resistant depression (TRD) with private or public insurance. Adults with ≥1 claim for esketamine nasal spray were selected from Clarivate’s Real World Data product (January 2016–March 2021). Patients with evidence of TRD initiating esketamine (index date) after 05 March 2019 were included. Esketamine access, as measured by pharmacy claim approval rate for each treatment session, and use patterns were described post-index (follow-up period). Among 535 patients with pharmacy claims for esketamine nasal spray (mean age 49.1 years; 65.4% females), 534 had the first esketamine claim being a pharmacy claim, of which 34.6% were approved, 46.3% were rejected, and 19.1% were abandoned. Main reasons for rejection included “claim not covered by plan” (57.1%), “claim errors” (52.6%), and “prior authorization required” (22.7%). The approval rate increased to 85.2% by the second esketamine treatment session. A total of 273 patients initiated esketamine (mean age 49.3 years; 66.3% females). Patients had a mean ± standard deviation (SD) of 11.8 ± 13.3 esketamine sessions over a mean ± SD of 11.8 ± 6.4 months; 47.6% of patients completed ≥8 sessions (i.e. the number of sessions in induction phase) over a mean ± SD of 80.1 ± 71.9 days (per label, 28 days); 48 (17.6%) patients completed induction per label, and among them 93.8% continued treatment. Initial access to esketamine nasal spray may be hindered by prior authorization or claim filing errors. Among patients who initiated esketamine, treatment compliance generally deviates from label recommendations; yet, most of those who received induction per label successfully transition to maintenance with esketamine. Esketamine nasal spray is a novel therapy for treatment-resistant depression (TRD). In the United States, insurance plans often regulate access to esketamine. Additionally, for patients, it may be challenging to comply to the treatment schedule, because patients must receive esketamine in a certified treatment center, be monitored for 2 h for potential side effects, and they cannot drive until the next day. This real-world study used insurance claims data and found that patients with TRD had difficulties accessing esketamine. Among those with access, esketamine use patterns were suboptimal.
Anano Makhashvili - Titus Andronicus and Tamora.pdf
Creators: name: Makhashvili, Anano
Publisher: name: figshare
Year: 2023
Subjects: British and Irish literature

description: Almost everyone has heard the name William Shakespeare. Many have read his plays, sonnets, and all his creations that are so valuable and important, interesting and comprehensive. Which topic is chosen by this or that person, which they consider most important, already depends on the reader, their thinking, views, and ideas. The topic of this research is Titus Andronicus. Why choose this play? Other plays that are no less interesting caught my attention, but in Titus Andronicus, we can see something that could be judged. At all times, especially in ancient times, revenge led to many conflicts or wars. Brother killed brother for revenge; no one trusted anyone. Revenge is the main focus of this research. The law of the boomerang” says it all. This research explores the justification of the revenge of the characters, Tamora and Titus, and their ruthless behavior. Even today, we can see revenge in its various forms but with less cruelty, since the law deters people from similar conduct.
The dualizing complex of $F$-injective and Du Bois singularities
Creators: name: Bhatt, Bhargav
name: Ma, Linquan
name: Schwede, Karl
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Let $(R,m,k)$ be an excellent local ring of equal characteristic. Let $j$ be a positive integer such that $H_m^i(R)$ has finite length for every $0\leq i 0$ or Du Bois in characteristic $0$, then the truncated dualizing complex $τ_{>-j}ω_R^\bullet$ is quasi-isomorphic to a complex of $k$-vector spaces. As a consequence, $F$-injective or Du Bois singularities with isolated non-Cohen-Macaulay locus are Buchsbaum. Moreover, when $R$ has $F$-rational or rational singularities on the punctured spectrum, we obtain stronger results.
description: 13 pages, final version, to appear in Math.Z
Noise filtering of composite pulses for singlet-triplet qubits
Creators: name: Yang, Xu-Chen
name: Wang, Xin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Semiconductor quantum dot spin qubits are promising candidates for quantum computing. In these systems, the dynamically corrected gates offer considerable reduction of gate errors and are therefore of great interest both theoretically and experimentally. They are, however, designed under the static-noise model and may be considered as low-frequency filters. In this work, we perform a comprehensive theoretical study of the response of a type of dynamically corrected gates, namely the {\sc supcode} for singlet-triplet qubits, to realistic $1/f$ noises with frequency spectra $1/ω^α$. Through randomized benchmarking, we have found that {\sc supcode} offers improvement of the gate fidelity for $α\gtrsim1$ and the improvement becomes exponentially more pronounced with the increase of the noise exponent in the range $1\lesssimα\leq3$ studied. On the other hand, for small $α$, {\sc supcode} will not offer any improvement. The $δJ$-{\sc supcode}, specifically designed for systems where the nuclear noise is absent, is found to offer additional error reduction than the full {\sc supcode} for charge noises. The computed filter transfer functions of the {\sc supcode} gates are also presented.
description: 9 pages, 5 figures
Free probability for purely discrete eigenvalues of random matrices
Creators: name: Collins, Benoit
name: Hasebe, Takahiro
name: Sakuma, Noriyoshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 60B20, 46L54

description: In this paper, we study random matrix models which are obtained as a non-commutative polynomial in random matrix variables of two kinds: (a) a first kind which have a discrete spectrum in the limit, (b) a second kind which have a joint limiting distribution in Voiculescu's sense and are globally rotationally invariant. We assume that each monomial constituting this polynomial contains at least one variable of type (a), and show that this random matrix model has a set of eigenvalues that almost surely converges to a deterministic set of numbers that is either finite or accumulating to only zero in the large dimension limit. For this purpose we define a framework (cyclic monotone independence) for analyzing discrete spectra and develop the moment method for the eigenvalues of compact (and in particular Schatten class) operators. We give several explicit calculations of discrete eigenvalues of our model.
description: 33 pages. Minor revisions
Hemmung der Selektin-vermittelten Granulozytenadhäsion durch Fucoidin in der frühen Reperfusionsphase nach Ischämie im Modell der ex-vivo hämoperfundierten Schweineniere
Creators: name: Lippek, Frank
Publisher: name: Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
Year: 2001
Subjects: subject: Ischämie-/Reperfusionsschaden
subject: Selektine
subject: isolierte Nierenperfusion
subject: Fucoidin
subject: ischemic-reperfusion injury
subject: selectins
subject: isolated kidney perfusion
subject: fucoidin
subject: 610 Medizin
subject: 33 Medizin
subject: YI 6500

description: Der renale Ischämie-/Reperfusionsschaden (IRI) stellt in der Transplantationsmedizin ein grosses Problem dar. Fucoidin, ein potenter Antagonist der Selektin-vermittelten Leukozytenaggregation, verbesserte an der Rattenleber (in einer Konzentration von 360mg/l) das Ausmass der leukozytären Gewebeinfiltration in der frühen Phase nach Ischämie und Reperfusion. In einem Modell der isoliert hämoperfundierten Schweineniere sollte die Wirkung von Fucoidin auf die postischämische Organfunktion untersucht werden. Hierzu wurden 24 Versuche durchgeführt. Dem Blut der Versuchsgruppen wurde vor Beginn der Reperfusion Fucoidin in einer Konzentration von 100 mg/l zugesetzt. Es zeigte sich unter Fucoidin ein signifikanter Abfall des renalen Blutflusses (55 ( 28 vs. 143 ( 97 ml*min-1*100g-1, p
description: Renal postischemic reperfusion injury constitutes a significant problem after kidney transplantation. The polysaccharide fucoidin (360 mg/l) improves postischemic function in Ratliver, presumably by blocking selectin-mediated leukocyte adhesion. Twelve pairs of ischemic pig kidneys were reperfused in an ex vivo model with autologous blood with or without fucoidin (100 mg/L). Fucoidin resulted in a significant decrease of renal blood flow (55 ( 28 vs. 143 ( 97 mL*min-1*100g-1, p < 0.001) and increased vascular resistance (2.9 ( 2.8 vs. 1.1 ( 1.5 mmHg*mL-1*min-1*100g-1, p < 0.001). Compared to untreated control kidneys significantly more interstitial and intravascular leucocytes were found in fucoidin treated kidneys. Intraglomerular fibrinogen and thrombocytic aggregates were also increased significantly. Granulocytic emboli were present in afferent glomerular arteries of 10/12 fucoidin-treated kidneys and in 2/12 controls (p < 0.001). L-selectin-dependent granulocytic aggregation under shear stress in vitro was prevented by fucoidin in a dose-dependent fashion. However similar concentrations used in reperfused kidneys caused large granulocytic aggregates. The observed formation of embolizing granulocytic aggregates indicates limited effectiveness of fucoidin as an inhibitor of selectin-mediated leukocyte adhesion.
Microwave study of superconducting Sn films above and below percolation
Creators: name: Beutel, Manfred H.
name: Ebensperger, Nikolaj G.
name: Thiemann, Markus
name: Untereiner, Gabriele
name: Fritz, Vincent
name: Javaheri, Mojtaba
name: Nägele, Jonathan
name: Rösslhuber, Roland
name: Dressel, Martin
name: Scheffler, Marc
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The electronic properties of superconducting Sn films ($T_c \approx$ 3.8 K) change significantly when reducing the film thickness down to a few nm, in particular close to the percolation threshold. The low-energy electrodynamics of such Sn samples can be probed via microwave spectroscopy, e.g. with superconducting stripline resonators. Here we study Sn thin films, deposited via thermal evaporation -ranging in thickness between 38 nm and 842 nm- which encompasses the percolation transition. We use superconducting Pb stripline resonators to probe the microwave response of these Sn films in a frequency range between 4 GHz and 20 GHz at temperatures from 7.2 K down to 1.5 K. The measured quality factor of the resonators decreases with rising temperature due to enhanced losses. As a function of the sample thickness we observe three regimes with significantly different properties: samples below percolation, i.e. ensembles of disconnected superconducting islands, exhibit dielectric properties with negligible losses, demonstrating that macroscopic current paths are required for appreciable dynamical conductivity of Sn at GHz frequencies. Thick Sn films, as the other limit, lead to low-loss resonances both above and below $T_c$ of Sn, as expected for bulk conductors. But in an intermediate thickness regime, just above percolation and with labyrinth-like morphology of the Sn, we observe a quite different behavior: the superconducting state has a microwave response similar to the thicker, completely covering films with low microwave losses; but the metallic state of these Sn films is so lossy that resonator operation is suppressed completely.
description: 9 pages, 5 figures
In vitro Charakterisierung autologer Aktivierung und Klonierung von T-Lymphozyten aus psoriatischen Plaques
Creators: name: Urban, Wiebke Dorothea
Publisher: name: Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
Year: 2005
Subjects: subject: Psoriasis
subject: T-Lymphozyten
subject: Interferon-gamma
subject: CD25-positiv
subject: psoriasis
subject: t cells
subject: gamma-Interferon
subject: CD25-positive
subject: 610 Medizin
subject: 33 Medizin
subject: YF 3404
subject: YF 3414
subject: YF 3415

description: Psoriasis ist eine komplexe entzündliche Erkrankung der Haut. Charakteristisch ist eine dichte Infiltration von T-Lymphozyten und eine Hyperproliferation der Epithelschicht. Heutzutage belegen die Ergebnisse vieler experimteller Studien, daß Psoriasis eine T-Zell-induzierte Erkrankung ist. Die Spezifität der T-Zell-stimulierenden Antigene ist noch unbekannt. Voraussetzung für die Charakterisierung psoriatischer T-Zellen ist die Isolation von T-Zell-Klonen aus psoriatischen Plaques, deren Restimulation in vitro qualitativ und quantitativ erfaßbar ist. Hierfür haben wir einen hochsensiblen gamma-Interferon Elispot-Assay etabiert, der die Aktivität der T-Zellen aus Hautplaques erfaßt. Zudem zeigen wir, daß man aktivierte T-Zell-Klone mittels CD25-Markierung isolieren und anschließend klonieren kann. Unsere Ergebnisse können als eine Grundlage für weitere Versuche dienen, die die Spezifität von T-Zell-Klonen aus psoriatischen Plaques charakterisieren sollen.
description: Psoriasis is a complex inflammatory disease of the skin characterized by a dense infiltration of T-lymphocytes and a hyperproliferation of the epithelial layer. A host of experimental and clinical data suggest that psoriasis is a T cell mediated disorder. The nature of T-cell-stimulating antigens is still unknown. One way to identify putative antigen(s) is the definition of T-cell-receptor specifities using randomized combinatorial peptide libraries. This requires the isolation and expansion of T cell clones from psoriatic plaques in vitro. Therefore we established a gamma-interferon Elispot-assay which allows quantification of the frequency of activated plaque-derived T cells in vitro. In addition, we show that activated T cell clones can be sorted via CD25 and cloned. The expanded clones can also be restimulated by autologous cells. Our results should be useful in the design of experiments aiming at a systematic analysis of the specifity of T cell clones present in psoriatic plaques.
On the relevance of language in speaker recognition
Creators: name: Satue-Villar, Antonio
name: Faundez-Zanuy, Marcos
Publisher: name: arXiv
Year: 2022
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Machine Learning (cs.LG)
subject: Sound (cs.SD)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: This paper presents a new database collected from a bilingual speakers set (49), in two different languages: Spanish and Catalan. Phonetically there are significative differences between both languages. These differences have let us to establish several conclusions on the relevance of language in speaker recognition, using two methods: vector quantization and covariance matrices
Cdh descent in equivariant homotopy K-theory
Creators: name: Hoyois, Marc
Publisher: name: arXiv
Year: 2016
Subjects: subject: K-Theory and Homology (math.KT)
subject: Algebraic Geometry (math.AG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: We construct geometric models for classifying spaces of linear algebraic groups in G-equivariant motivic homotopy theory, where G is a tame group scheme. As a consequence, we show that the equivariant motivic spectrum representing the homotopy K-theory of G-schemes (which we construct as an E-infinity-ring) is stable under arbitrary base change, and we deduce that homotopy K-theory of G-schemes satisfies cdh descent.
description: 17 pages. v4: final version, appeared in Documenta; v3: new title & minor improvements
Classical dynamics of the Bianchi IX model with timelike singularity
Creators: name: Parnovsky, S. L.
name: Piechocki, W.
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the dynamics of the vacuum Bianchi IX model with timelike singularity and compare it with the dynamics of the Bianchi IX model with cosmological singularity. We show that differences in the signs of some terms in the set of equations specifying the dynamics of both spacetimes lead to significant differences in their properties.
description: 11 pages, 2 figures, version to appear in GRG
Hand-waving and Interpretive Dance: An Introductory Course on Tensor Networks
Creators: name: Bridgeman, Jacob C.
name: Chubb, Christopher T.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The curse of dimensionality associated with the Hilbert space of spin systems provides a significant obstruction to the study of condensed matter systems. Tensor networks have proven an important tool in attempting to overcome this difficulty in both the numerical and analytic regimes. These notes form the basis for a seven lecture course, introducing the basics of a range of common tensor networks and algorithms. In particular, we cover: introductory tensor network notation, applications to quantum information, basic properties of matrix product states, a classification of quantum phases using tensor networks, algorithms for finding matrix product states, basic properties of projected entangled pair states, and multiscale entanglement renormalisation ansatz states. The lectures are intended to be generally accessible, although the relevance of many of the examples may be lost on students without a background in many-body physics/quantum information. For each lecture, several problems are given, with worked solutions in an ancillary file.
description: Published version. Introductory lecture notes, worked solutions to problems in ancillary file. Comments welcome
Entrepreneuriat social et bien-être social : Rôle du capital humain et social dans les coopératives de la région Guelmim Oued Noun
Creators: name: Salah DRIOUCH
name: Abdeljalil MAZZAOUROU
Publisher: name: Zenodo
Year: 2024

description: L'objectif de cette étude est d'analyser la contribution de l'entrepreneuriat social à l'amélioration du bien-être social de la population. Une revue de littérature exhaustive a été entreprise pour définir précisément le cadre et la portée des activités liées à l'entrepreneuriat social, tandis qu'une évaluation de sa contribution au bien-être social s'est focalisée sur le rôle du capital humain et social des coopératives dans cette dynamique. Dans ce contexte, une modélisation SEM (Structural Equation Model) a été réalisée avec la procédure SmartPLS V.3, appliquée à un échantillon représentatif de coopératives opérant dans la province de Guelmim. L'analyse visait à mettre en lumière les relations potentielles entre le rôle du capital humain et social dans les pratiques entrepreneuriales des coopératives et l'amélioration de leur bien-être social, adoptant ainsi une approche méthodologique rigoureuse dans une perspective académique, soulignant l'importance d'une compréhension approfondie des mécanismes sous-jacents à ces relations cruciales pour le développement social.
Clouds in Super-Earth Atmospheres: Chemical Equilibrium Calculations
Creators: name: Mbarek, Rostom
name: Kempton, Eliza M. -R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Recent studies have unequivocally proven the existence of clouds in super-Earth atmospheres (Kreidberg et al. 2014). Here we provide a theoretical context for the formation of super-Earth clouds by determining which condensates are likely to form under the assumption of chemical equilibrium. We study super-Earth atmospheres of diverse bulk composition, which are assumed to form by outgassing from a solid core of chondritic material, following Schaefer & Fegley (2010). The super-Earth atmospheres that we study arise from planetary cores made up of individual types of chondritic meteorites. They range from highly reducing to oxidizing and have carbon to oxygen (C:O) ratios that are both subsolar and super-solar, thereby spanning a range of atmospheric composition that is appropriate for low-mass exoplanets. Given the atomic makeup of these atmospheres, we minimize the global Gibbs free energy of formation for over 550 gases and condensates to obtain the molecular composition of the atmospheres over a temperature range of 350-3,000 K. Clouds should form along the temperature-pressure boundaries where the condensed species appear in our calculation. We find that the composition of condensate clouds depends strongly on both the H:O and C:O ratios. For the super-Earth archetype GJ 1214b, KCl and ZnS are the primary cloud-forming condensates at solar composition, in agreement with previous work (Morley et al. 2013; Miller-Ricci Kempton et al. 2012). However, for oxidizing atmospheres, K2SO4 and ZnO condensates are favored instead, and for carbon-rich atmospheres with super-solar C:O ratios, graphite clouds appear. For even hotter planets, clouds form from a wide variety of rock-forming and metallic species.
description: 11 pages, 6 figures, Accepted to ApJ
Quantum criticality with a twist - interplay of correlations and Kohn anomalies in three dimensions
Creators: name: Schäfer, T.
name: Katanin, A. A.
name: Held, K.
name: Toschi, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A general understanding of quantum phase transitions in strongly correlated materials is still lacking. By exploiting a cutting-edge quantum many-body approach, the dynamical vertex approximation, we make an important progress, determining the quantum critical properties of the antiferromagnetic transition in the fundamental model for correlated electrons, the Hubbard model in three dimensions. In particular, we demonstrate that -in contradiction to the conventional Hertz-Millis-Moriya theory- its quantum critical behavior is driven by the Kohn anomalies of the Fermi surface, even when electronic correlations become strong.
description: 6 pages, 4 figures (8 pages Supplemental Material)
Building blocks of the basin stability of power grids
Creators: name: Kim, Heetae
name: Lee, Sang Hoon
name: Holme, Petter
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Given a power grid and a transmission (coupling) strength, basin stability is a measure of synchronization stability for individual nodes. Earlier studies have focused on the basin stability's dependence of the position of the nodes in the network for single values of transmission strength. Basin stability grows from zero to one as transmission strength increases, but often in a complex, nonmonotonous way. In this study, we investigate the entire functional form of the basin stability's dependence on transmission strength. To be able to perform a systematic analysis, we restrict ourselves to small networks. We scan all isomorphically distinct networks with an equal number of power producers and consumers of six nodes or less. We find that the shapes of the basin stability fall into a few, rather well-defined classes, that could be characterized by the number of edges and the betweenness of the nodes, whereas other network positional quantities matter less.
description: 7 pages, 6 figures
The Impact of Adjacent Channel Interference in Multi-Radio Systems using IEEE 802.11
Creators: name: Nachtigall, Jens
name: Zubow, Anatolij
name: Redlich, Jens-Peter
Publisher: name: Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II
Year: 2008
Subjects: subject: Wireless Networks
subject: Multi-Radio
subject: Multi-Channel
subject: Cross-Channel
subject: Adjacent Channel Interference
subject: Measurements
subject: 004 Informatik

description: A promising approach for improving the capacity of Wireless Mesh Networks is by making use of multiple non-overlapping RF channels. Multi-channel protocols have the advantage that several devices can transmit in parallel within a collision domain on distinct channels. When using IEEE 802.11b/g/a most protocol designers assume 3 and 12 non-overlapping channels, respectively. However, this simplified assumption does not hold. We present results from measurements that show that the number of available non-interfering channels depends on the antenna separation, PHY modulation, RF band, traffic pattern and whether single- or multi-radio systems are used. The problem is caused by Adjacent Channel Interference (ACI) where nearby transmitters "bleed over" to other frequencies and either cause spurious carrier sensing or frame corruption. For nearby transceivers, as in the factory defaults of multi-radio devices, this results in at most two non-interfering channels, one within 2.4 GHz and the other within the 5 GHz band. Only if the distance between the antennas is increased, non-interfering channels within the bands themselves become available. Moreover, our comparison of single- and multi-radio systems allows us to isolate ACI from board crosstalk and radiation leakage of which only the multi-radio systems seem to suffer. Finally, we show how a packet-level simulator can be improved to realistically incorporate ACI. With the help of this simulator more confident statements about the performance of various multi-channel protocols can be made.
Nonadditivity of Rains' bound for distillable entanglement
Creators: name: Wang, Xin
name: Duan, Runyao
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Rains' bound is arguably the best known upper bound of the distillable entanglement by operations completely preserving positivity of partial transpose (PPT) and was conjectured to be additive and coincide with the asymptotic relative entropy of entanglement. We disprove both conjectures by explicitly constructing a special class of mixed two-qubit states. We then introduce an additive semidefinite programming lower bound ($E_M$) for the asymptotic Rains' bound, and it immediately becomes a computable lower bound for entanglement cost of bipartite states. Furthermore, $E_M$ is also proved to be the best known upper bound of the PPT-assisted deterministic distillable entanglement and gives the asymptotic rates for all pure states and some class of genuinely mixed states.
description: 6 pages, title changed, closed to the published version
A Data-driven Study of View Duration on YouTube
Creators: name: Park, Minsu
name: Naaman, Mor
name: Berger, Jonah
Publisher: name: arXiv
Year: 2016
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Video watching had emerged as one of the most frequent media activities on the Internet. Yet, little is known about how users watch online video. Using two distinct YouTube datasets, a set of random YouTube videos crawled from the Web and a set of videos watched by participants tracked by a Chrome extension, we examine whether and how indicators of collective preferences and reactions are associated with view duration of videos. We show that video view duration is positively associated with the video's view count, the number of likes per view, and the negative sentiment in the comments. These metrics and reactions have a significant predictive power over the duration the video is watched by individuals. Our findings provide a more precise understandings of user engagement with video content in social media beyond view count.
description: 4 pages, 2 tables, Accepted to the 10th International AAAI Conference on Web and Social Media, ICWSM'16
Iterated Kodaira Fibrations and Surface Bundles
Creators: name: Zhu, Kejia
Publisher: name: University of Illinois at Chicago
Year: 2023

description: In order to determine when surface-by-surface bundles are non-positively curved, Llosa Isenrich and Py give a necessary condition: given a surface-by-surface group G with infinite monodromy, if G is CAT(0) then the monodromy representation is injective. We extend this to a more general result: Let G be a group with a normal surface subgroup R. Assume G/R satisfies the property that for every infinite normal subgroup Λ of G/R, there is an infinite subgroup Λ0<Λ so that the centralizer CG/R(Λ0) is finite. If G is CAT(0) with infinite monodromy, then the monodromy representation has a finite kernel. We prove that acylindrically hyperbolic groups satisfy this property.