cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genome-wide DNA methylation sequencing identifies epigenetic perturbations in the upper airways under long-term exposure to moderate levels of ambient air pollution
Creators: name: Messingschlager, Marey
name: Bartel-Steinbach, Martina
name: Mackowiak, Sebastian D.
name: Straff, Wolfgang
Publisher: name: My University
Year: 2023
Subjects: PM10

description: While the link between exposure to high levels of ambient particulate matter (PM) and increased incidences of respiratory and cardiovascular diseases is widely recognized, recent epidemiological studies have shown that low PM concentrations are equally associated with adverse health effects. As DNA methylation is one of the main mechanisms by which cells regulate and stabilize gene expression, changes in the methylome could constitute early indicators of dysregulated signaling pathways. So far, little is known about PM-associated DNA methylation changes in the upper airways, the first point of contact between airborne pollutants and the human body. Here, we focused on cells of the upper respiratory tract and assessed their genome-wide DNA methylation pattern to explore exposure-associated early regulatory changes. Using a mobile epidemiological laboratory, nasal lavage samples were collected from a cohort of 60 adults that lived in districts with records of low (Simmerath) or moderate (Stuttgart) PM10 levels in Germany. PM10 concentrations were verified by particle measurements on the days of the sample collection and genome-wide DNA methylation was determined by enzymatic methyl sequencing at single-base resolution. We identified 231 differentially methylated regions (DMRs) between moderately and lowly PM10 exposed individuals. A high proportion of DMRs overlapped with regulatory elements, and DMR target genes were involved in pathways regulating cellular redox homeostasis and immune response. In addition, we found distinct changes in DNA methylation of the HOXA gene cluster whose methylation levels have previously been linked to air pollution exposure but also to carcinogenesis in several instances. The findings of this study suggest that regulatory changes in upper airway cells occur at PM10 levels below current European thresholds, some of which may be involved in the development of air pollution-related diseases. Quelle: Elsevier
title: Conceptos claves de la imagen en la escoliosis, puesta al día.
Creators: name: Lannegrand Menéndez, Beatriz
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Musculoskeletal system
subject: Conventional radiography
subject: MR
subject: CT

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Se van a tratar los siguientes objetivos: 1. Definir las medidas básicas que deben conocer los radiólogos para la evaluación de la escoliosis. 2. Identificar el tipo y grado de escoliosis,
según las clasificaciones actuales traumatológicas. 3....
Exploring Knowledge Graphs with Directed/Mixed Graph Isomorphism
Creators: name: Wu, Yuanyuan
Publisher: name: Swinburne
Year: 2024

description: Recent years have witnessed a rapid growth of knowledge applied extensively in both academia and industry. This thesis mainly focuses on exploring KGs with graph-based computational approaches, including a novel algorithm for directed/mixed graph isomorphism in polynomial time. Furthermore, the effectiveness and efficiency of the proposed approaches are verified by their application on the identification of money laundering behavior in transactional KGs and the construction and exploration of viral/chemical similarity KGs regarding novel coronavirus disease 2019 (COVID-19). The proposed approaches in this thesis may contribute to more informed decision-making in a wide range of areas.
title: Diagnóstico por imagen de las neoplasias de las vias urinarias superiores.
Creators: name: Mas Gelabert, Miguel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Ultrasound
subject: CT
subject: MR
subject: Kidney

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Determinar las técnicas de imagen más adecuadas y los signos radiológicos observados en los tumores de las vias urinarias superiores,
aportando nuestra experiencia. Se correlacionan las imágenes de los casos de nuestro hospital con los datos...
ZFire: Using Hα equivalent widths to investigate the in situ initial mass function at z ∼ 2
Creators: name: Nanayakkara, Themiya
name: Glazebrook, Karl
name: Kacprzak, Glenn
name: Yuan, Tiantian
name: Fisher, Deanne
name: Tran, Kim Vy
name: Kewley, Lisa J.
name: Spitler, Lee
name: Alcorn, Leo
name: Cowley, Michael
name: Labbe, Ivo
name: Straatman, Caroline
name: Tomczak, Adam
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We use the ZFIRE (http://zfire.swinburne.edu.au) survey to investigate the high-mass slope of the initial mass function (IMF) for a mass-complete (
log10(M∗/M⊙)∼9.3
) sample of 102 star-forming galaxies at z ∼ 2 using their Hα equivalent widths (Hα EWs) and rest-frame optical colours. We compare dust-corrected Hα EW distributions with predictions of star formation histories (SFHs) from pegase.2 and starburst
99
synthetic stellar population models. We find an excess of high Hα EW galaxies that are up to 0.3–0.5 dex above the model-predicted Salpeter IMF locus and the Hα EW distribution is much broader (10–500 Å) than can easily be explained by a simple monotonic SFH with a standard Salpeter-slope IMF. Though this discrepancy is somewhat alleviated when it is assumed that there is no relative attenuation difference between stars and nebular lines, the result is robust against observational biases, and no single IMF (i.e. non-Salpeter slope) can reproduce the data. We show using both spectral stacking and Monte Carlo simulations that starbursts cannot explain the EW distribution. We investigate other physical mechanisms including models with variations in stellar rotation, binary star evolution, metallicity and the IMF upper-mass cut-off. IMF variations and/or highly rotating extreme metal-poor stars (Z ∼ 0.1 Z⊙) with binary interactions are the most plausible explanations for our data. If the IMF varies, then the highest Hα EWs would require very shallow slopes (Γ > −1.0) with no one slope able to reproduce the data. Thus, the IMF would have to vary stochastically. We conclude that the stellar populations at z ≳ 2 show distinct differences from local populations and there is no simple physical model to explain the large variation in Hα EWs at z ∼ 2.
Simulation and experimental study of room acoustics
Creators: name: Zhang, Wei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Mechanical.
subject: Physics, Acoustics.

description: Sound propagation is a complex subject, especially in an enclosure. The study of room acoustics involves not only a research into how sound is propagated in a room, but also a search into how to measure sound under different condition and how to control sound in the case of various wall materials. For an acoustical environment, there are three separated parts: sound sources, room acoustics, and the listens. These three items form a source-medium-receiver chain, which is typical for most of communication models. In this thesis, the image method is applied to predict the acoustical quality of a real room, and the experiment for room acoustic measurement is set up. The simulation model using image method proved the design of the measurement system is efficient for room acoustics.
Software-assisted dosimetry in peptide receptor radionuclide therapy with 177Lutetium-DOTATATE for various imaging scenarios
Creators: name: Kupitz, Dennis
name: Wetz, Christoph
name: Wissel, Heiko
name: Wedel, Florian
name: Apostolova, Ivayla
name: Wallbaum, Thekla
name: Rieke, Jens
name: Amthauer, Holger
name: Grosser, Oliver S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In peptide receptor radionuclide therapy (PRRT) of patients with neuroendocrine neoplasias (NENs), intratherapeutic dosimetry is mandatory for organs at risk (e.g. kidneys) and tumours. We evaluated commercial dosimetry software (Dosimetry Toolkit) using varying imaging scenarios, based on planar and/or tomographic data, regarding the differences in calculated organ/tumour doses and the use for clinical routines. A total of 16 consecutive patients with NENs treated by PRRT with 177Lu-DOTATATE were retrospectively analysed. Single-photon emission computed tomography (SPECT)/low-dose computed tomography (CT) of the thorax and abdomen and whole body (WB) scintigraphy were acquired up to 7 days p.i. (at a maximum of five imaging time points). Different dosimetric scenarios were evaluated: (1) a multi-SPECT-CT scenario using SPECT/CT only; (2) a planar scenario using WB scintigraphy only; and (3) a hybrid scenario using WB scintigraphy in combination with a single SPECT /low-dose CT. Absorbed doses for the kidneys, liver, spleen, lungs, bladder wall and tumours were calculated and compared for the three different scenarios. The mean absorbed dose for the kidneys estimated by the multi- SPECT-CT, the planar and the hybrid scenario was 0.5 ± 0.2 Sv GBq-1, 0.8 ± 0.4 Sv GBq-1 and 0.6 ± 0.3 Sv GBq-1, respectively. The absorbed dose for the residual organs was estimated higher by the planar scenario compared to the multi-SPECT-CT or hybrid scenario. The mean absorbed tumour doses were 2.6 ± 1.5 Gy GBq-1 for the multi-SPECT-CT, 3.1 ± 2.2 Gy GBq-1 for the hybrid scenario and 5.3 ± 6.3 Gy GBq-1 for the planar scenario. SPECT-based dosimetry methods determined significantly lower kidney doses than the WB scintigraphy- based method. Dosimetry based completely on SPECT data is time-consuming and tedious. Approaches combining SPECT/CT and WB scintigraphy have the potential to ensure compromise between accuracy and user-friendliness.
Laboratory conditions can change the complexity and composition of the natural aquatic mycobiome on Alnus glutinosa leaf litter
Creators: name: Carl, Steffen C.
name: Gergs, René
name: Mohr, Silvia
name: Sahm, René
Publisher: name: My University
Year: 2022
Subjects: Artenvielfalt
Verwitterung
Limnologie

description: Community structure is of major interest when aquatic fungi are studied, particularly in leaf decomposition experiments. Although such studies are often conducted as laboratory experiments with microbial communities taken from the field, it remains unclear to what extent natural fungal communities can be sustained under experimental conditions. Here, we used DNA metabarcoding to investigate the development of fungal communities on alder leaves both under laboratory and field conditions. Five leaf conditioning treatments were compared by colonizing leaves in a stream, exposing stream colonized leaves to a defined medium or filtered stream water and using stream colonized leaves to inoculate sterile leaves in the defined medium or stream water. Fewer species were found on leaves that were inoculated under laboratory conditions, whereas differences in fungal community composition were comparably low in the other treatments, irrespective of the chosen medium. Possible shifts in fungal communities should therefore be considered in laboratory experiments. © 2021 The Authors
title: Hallazgo casual de complicaciones vasculares en el paciente oncológico, más allá del tromboembolismo pulmonar.
Creators: name: Pascual Robles, Maria Dolores
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Embolism / Thrombosis
subject: Aneurysms
subject: Contrast agent-intravenous
subject: CT
subject: Vascular
subject: Thorax
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir el amplio rango de las complicaciones vasculares en pacientes oncológicos que pueden identificarse en los estudios rutinarios de...
Turbulent molecular gas and star formation in the shocked intergalactic medium of Stephan's quintet
Creators: name: Guillard, P.
name: Boulanger, F.
name: Pineau des Forets, G.
name: Falgarone, E.
name: Gusdorf, A.
name: Cluver, Michelle
name: Appleton, P. N.
name: Lisenfeld, U.
name: Duc, P.-A.
name: Ogle, P. M.
name: Xu, C. K.
Publisher: name: Swinburne
Year: 2024

description: The Stephan's Quintet (hereafter SQ) is a template source to study the impact of galaxies interaction on the physical state and energetics of their gas. We report on IRAM single-dish CO observations of the SQ compact group of galaxies. These observations follow up the Spitzer discovery of bright mid-IR H2 rotational line emission (L(H2) ≈ 1035 W) from warm (102 - 3 K) molecular gas, associated with a 30 kpc long shock between a galaxy, NGC 7318b, and NGC 7319's tidal arm. We detect CO(1-0), (2-1) and (3-2) line emission in the inter-galactic medium (IGM) with complex profiles, spanning a velocity range of ≈1000 km s-1. The spectra exhibit the pre-shock recession velocities of the two colliding gas systems (5700 and 6700 km s-1), but also intermediate velocities. This shows that much of the molecular gas has formed out of diffuse gas accelerated by the galaxy-tidal arm collision. CO emission is also detected in a bridge feature that connects the shock to the Seyfert member of the group, NGC 7319, and in the northern star forming region, SQ-A, where a new velocity component is identified at 6900 km s-1, in addition to the two velocity components already known. Assuming a Galactic CO(1-0) emission to H2 mass conversion factor, a total H2 mass of ≈5 × 109 M ⊙ is detected in the shock. The ratio between the warm H2 mass derived from Spitzer spectroscopy, and the H2 mass derived from CO fluxes is ≈0.3 in the IGM of SQ, which is 10--100 times higher than in star-forming galaxies. The molecular gas carries a large fraction of the gas kinetic energy involved in the collision, meaning that this energy has not been thermalized yet. The kinetic energy of the H2 gas derived from CO observations is comparable to that of the warm H2 gas from Spitzer spectroscopy, and a factor ≈5 greater than the thermal energy of the hot plasma heated by the collision. In the shock and bridge regions, the ratio of the PAH-to-CO surface luminosities, commonly used to measure the star formation efficiency of the H2 gas, is lower (up to a factor 75) than the observed values in star-forming galaxies. We suggest that turbulence fed by the galaxy-tidal arm collision maintains a high heating rate within the H2 gas. This interpretation implies that the velocity dispersion on the scale of giant molecular clouds in SQ is one order of magnitude larger than the Galactic value. The high amplitude of turbulence may explain why this gas is not forming stars efficiently.
title: Revisión del carcinoma de vesicula
Creators: name: Hernandez Caler, Rocio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: CT
subject: Ultrasound
subject: Contrast agent-intravenous
subject: Contrast agent-oral
subject: Pathology
subject: Neoplasia

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Describir los aspectos epidemiológicos,
clínicos y radiológicos del carcinoma de vesícula (CV) Valorar la utilidad de las principales pruebas de imagen radiológicas (ecografía abdominal,
TC abdomen sin y con contraste intravenoso CIV y RM) en...
The effect of cisplatin on the role of proprotein convertases (PCs) in human ovarian cancer cells
Creators: name: Boulay, Hillary Michelle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Cell.

description: Proprotein convertases (PCs) have been implicated in cancer progression as well as cell survival, although their role in ovarian cancer and drug sensitivity is largely unknown. Of all the PCs, PC4 has the most restricted expression; present only in reproductive tissues (testis, ovary and placenta). The expression and regulation of PC4 were investigated using a pair of cisplatin-sensitive and -resistant cell lines as an in vitro model of ovarian cancer. PC4 is expressed in the ovarian cancer cell lines as well as in tumours from patients diagnosed with the disease. Over-expression of PC4 in chemosensitive cells attenuated cisplatin (CDDP)-induced apoptosis, while inhibition of PC4 activity or down-regulation of PC4 by siRNA sensitized chemoresistant cells to the apoptotic effects of CDDP. Furthermore, current data suggests that the role of PC4 in chemoresistance may be mediated through the processing and activation of IGF-II. These data demonstrate for the first time that PC4 is anti-apoptotic and imply its involvement in the chemoresistance of human ovarian cancer cells.
Constructing a WISE high resolution galaxy atlas
Creators: name: Jarrett, T. H.
name: Masci, F.
name: Tsai, C. W.
name: Petty, S.
name: Cluver, Michelle
name: Assef, Roberto J.
name: Benford, D.
name: Blain, A.
name: Bridge, C.
name: Donoso, E.
name: Eisenhardt, P.
name: Fowler, J.
name: Koribalski, B.
name: Lake, S.
name: Neill, James D.
name: Seibert, M.
name: Sheth, K.
name: Stanford, S.
name: Wright, E.
Publisher: name: Swinburne
Year: 2024

description: After eight months of continuous observations, the Wide-field Infrared Survey Explorer (WISE) mapped the entire sky at 3.4 μm, 4.6 μm, 12 μm, and 22 μm. We have begun a dedicated WISE High Resolution Galaxy Atlas project to fully characterize large, nearby galaxies and produce a legacy image atlas and source catalog. Here we summarize the deconvolution techniques used to significantly improve the spatial resolution of WISE imaging, specifically designed to study the internal anatomy of nearby galaxies. As a case study, we present results for the galaxy NGC 1566, comparing the WISE enhanced-resolution image processing to that of Spitzer, Galaxy Evolution Explorer, and ground-based imaging. This is the first paper in a two-part series; results for a larger sample of nearby galaxies are presented in the second paper.
Lead Oxide and Lead-containing Slag/Glass Reduction Using Hydrogen
Creators: name: Rukini, Asywendi
Publisher: name: Swinburne
Year: 2024

description: The current study highlights the potential of decarbonisation of the lead metal industry by utilizing hydrogen reduction in processing and recycling lead-containing slag. This study emphasizes the current limited understanding of hydrogen's role as a reductant in reducing lead-containing slag, particularly in the context of complex industrial metal production slags. The study aims to address this knowledge gap by conducting a systematic investigation, ranging from simple (PbO) to complex slag systems (PbO-SiO2, PbO-SiO2-CaO, and PbO-SiO2-CaO-Fe2O3). The focus is on understanding the thermodynamics, kinetics, and mechanisms involved in the hydrogen reduction of these systems, supported by detailed materials characterization.
Histoire alluviale de la riviere Porcupine dans la plaine de Bluefish au Yukon septentrional, de 14 ka B.P. a aujourd'hui.
Creators: name: Riel, Alain.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Physical Geography.

description: La riviese Porcupine qui prend naissance dans les monts Ogilvie, au Yukon septentrional, est caracterisee par de nombreux meandres quand elle traverse la plaine de Bluefish. Cette plaine, etablie dans un bassin tectonique datant du Tertiaire, a accumule au cours du Cenozoique des sediments qui, a l'Holocene, ont ete entailles par la riviere. La photo-interpretation des depots superficiels de la riviere Porcupine a l'interieur de la plaine de Bluefish a permis d'identifier trois categories de depots meubles soit du gravier, du sable et du limon. Une etude sedimentologique a ete effectuee le long de la riviere Porcupine sur une distance d'environ 84 kilometres. A l'interieur de cette section, 6 coupes stratigraphiques ont ete etudiees et 87 echantillons ont ete retenus pour des fins d'analyses sedimentologiques. Les resultats de l'analyse granulometrique ont ete soumis a une analyse bivariees: le diagramme Md/Qd (phi) de Krumbein. La combinaison de cette analyse avec celles des datations radiocarbones et a la position geographique des coupes etudiees, a permis de reconstruire l'histoire alluviale de la riviere Porcupine dans la plaine de 14 ka B.P. a aujourd'hui. Les principaux resultats sont: (1) Un encaissement rapide (50 m), entre 14 ka et 12 ka B.P. suite a une decharge fluvio-glaciaire qui mit en place des terrasses d'erosion. (2) L'edification d'une terrasse liee a une phase de sedimentation intense associee a la fin de la decharge glacio-lacustre. (3) L'edification d'une terrasse moderne a quelques metres de la surface de la riviere Porcupine. Cette terrasse est en equilibre avec l'hydrologie actuelle.
title: Tumores y lesiones pseudotumorales del mediastino anterior
Creators: name: Cañete Abajo, Noemí
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: MR
subject: Thorax
subject: Mediastinum

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir los hallazgos radiológicos de los tumores y lesiones pseudotumorales del mediastino anterior. Describir y reconocer las características radiológicas específicas de algunas de estas...
Proceedings of the Workshop "Decarbonisation - 100 % Renewable Energy and more" 9 November 2015 in Berlin
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Erneuerbare Energie
subject: renewable energy
subject: decarbonisation
subject: Klima | Energie
subject: Climate | Energy

description: The workshop "Decarbonisation - 100% Renewable Energy and moreŁ, was held on 9 November 2015 in Berlin, hosted by the German Environment Agency and organised by Ecologic Institute. It offered a valuable opportunity for decision-makers, academia, business and civil society fromEUMember States, to exchange ideas and lessons learned on the design and implementation of longterm decarbonisation strategies and discuss how industrialised nations, regions and cities can mitigate greenhouse gas emissions in various economic sectors.Quelle: https://www.umweltbundesamt.de
description: The workshop “Decarbonisation – 100% Renewable Energy and more”, was held on 9 November 2015 in Berlin, hosted by the German Environment Agency and organised by Ecologic Institute. It offered a valuable opportunity for decision-makers, academia, business and civil society from EU Member States, to exchange ideas and lessons learned on the design and implementation of longterm decarbonisation strategies and discuss how industrialised nations, regions and cities can mitigate greenhouse gas emissions in various economic sectors.
Change in Referral Patterns to Nephrologists after Estimated Glomerular Filtration Rate (eGFR) Reporting: An interrupted time series analysis
Creators: name: Akbari, Ayub
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Health Sciences, Epidemiology.

description: Objectives: To update a Cochrane review of interventions to improve outpatient referral and to assess changes in referrals to nephrologists after initiating automatic estimated glomerular filtration rate (eGFR) reporting. Methods: Systematic review using standardized Cochrane methods. Before and after study with interrupted time series analysis using data from retrospective chart review on referrals from family medicine to nephrology. Results: Review added one new study and removed one for total of 17 studies. Referrals improved with education and structured referral sheets. Of 2766 eligible referrals for one-year pre-eGFR reporting to one-year post, 96.6% were reviewed. There was a 68.2% increase in referrals for chronic kidney disease (P < 0.01) and a 64.1% increase in total appropriate referrals (P =0.01) with no significant change in proportion of appropriate referrals (-2.5%, P=0.56). Conclusion: Systematic review findings did not change from the previous review. eGFR reporting increased both appropriate and inappropriate referrals.
Design and performance analyses of solar arrays towards a metric of energy value
Creators: name: Boivin, Adrian
name: Westgate, Timothy M.
name: Holzman, Jonathan
Publisher: name: The University of British Columbia
Year: 2021

description: In this work, the contemporary approach of analyzing and optimizing solar technology according to conversion efficiency is expanded upon to recognize an emerging paradigm for supply and demand of solar power. The analyses and optimizations are carried out with respect to energy value density, in units of dollars per metre‐squared, rather than simple energy density, in units of watt‐hours per metre‐squared, given an emerging trend in electricity prices that has become known as the Duck Curve. Such an approach is motivated by economic factors, in areas such as California, where dynamic solar power generation leads to high supply during mid‐day hours, when the demand is low, and low supply during early‐ and late‐day hours, when the demand is high. With this in mind, the metric of energy value density is analyzed for three silicon‐based solar arrays: the Flat‐Panel Array, as an established benchmark, the V‐Groove Array, as an array with enhanced conversion efficiency, and the U‐Groove Array, as a newly‐proposed array with strong performance for energy value density. Experimental characterizations and theoretical analyses are shown for the arrays' energy value density over July 2012 to June 2018. It is shown that the U‐Groove Array yields the greatest performance in terms of energy value density – and the extent of its outperformance is growing. Over the last year of the study, the U‐Groove Array generated 0.36% more value than the V‐Groove Array and 8.76% more value than the Flat‐Panel Array. The prospects for such findings to the solar industry are discussed.
title: Relationship between bone turnover and left ventricular function in primary hyperparathyroidism
title: The EPATH trial
titleType: Subtitle
Creators: name: Verheyen, Nicolas
name: Fahrleitner-Pammer, Astrid
name: Belyavskiy, Evgeny
name: Gruebler, Martin R.
name: Dimai, Hans Peter
name: Amrein, Karin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Observational studies suggested a link between bone disease and left ventricular (LV) dysfunction that may be pronounced in hyperparathyroid conditions. We therefore aimed to test the hypothesis that circulating markers of bone turnover correlate with LV function in a cohort of patients with primary hyperparathyroidism (pHPT). Cross-sectional data of 155 subjects with pHPT were analyzed who participated in the “Eplerenone in Primary Hyperparathyroidism” (EPATH) Trial. Multivariate linear regression analyses with LV ejection fraction (LVEF, systolic function) or peak early transmitral filling velocity (e’, diastolic function) as dependent variables and N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin (OC), bone- specific alkaline phosphatase (BALP), or beta-crosslaps (CTX) as the respective independent variable were performed. Analyses were additionally adjusted for plasma parathyroid hormone, plasma calcium, age, sex, HbA1c, body mass index, mean 24-hours systolic blood pressure, smoking status, estimated glomerular filtration rate, antihypertensive treatment, osteoporosis treatment, 25-hydroxy vitamin D and N-terminal pro-brain B-type natriuretic peptide. Independent relationships were observed between P1NP and LVEF (adjusted β-coefficient = 0.201, P = 0.035) and e’ (β = 0.188, P = 0.042), respectively. OC (β = 0.192, P = 0.039) and BALP (β = 0.198, P = 0.030) were each independently related with e’. CTX showed no correlations with LVEF or e’. In conclusion, high bone formation markers were independently and paradoxically related with better LV diastolic and, partly, better systolic function, in the setting of pHPT. Potentially cardio-protective properties of stimulated bone formation in the context of hyperparathyroidism should be explored in future studies.
On r-quick convergence in the law of the interated logarithm for a class of dependent sequences.
Creators: name: Dabrowski, Andre Robert.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1978
Subjects: subject: Mathematics.

description: In this thesis we study Law of the Iterated Logarithm type properties for stationary *-mixing sequences of real random variables Xi infinityi=1 under certain moment conditions. Essentially we prove that under the assumption that all moments of X1 exist finitely then for any r > 0 we have an r-quick analogue to the functional form of the Law of the Iterated Logarithm. The treatment demonstrates the result directly from the asymptotic properties of the sequence. Several applications along the lines of those given by Strassen of the functional Law of the Iterated Logarithm are also presented.
title: Europäische Mobilitätswoche 16-22 September
title: Europäische Mobilitätswoche 16-22 September
titleType: AlternativeTitle
title: EMW-Leitfaden 2019
titleType: AlternativeTitle
Creators: name: Kiso, Claudia
name: Zarske, Maja
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: subject: Nachhaltige Mobilität
subject: Europäische Mobilitätswoche
subject: EMW
subject: Verkehr

description: Die EUROPÄISCHE MOBILITÄTSWOCHE (kurz EMW) ist eine Kampagne der Europäischen Kommission. Jedes Jahr vom 16. bis 22. September bietet sie Kommunen aus ganz Europa die perfekte Möglichkeit, ihren Bürgerinnen und Bürgern die komplette Bandbreite nachhaltiger Mobilität vor Ort näher zu bringen. Der neue EMW-Leitfaden 2019 für Deutschland fasst auf 36 Seiten alle wichtigen Informationen rund um die EMW zusammen und bietet außerdem durch 18 neue Praxisbeispiele aus Deutschland und dem europäischen Ausland Inspirationen für die eigene Teilnahme. Quelle: https://www.umweltbundesamt.de
description: Die EUROPÄISCHE MOBILITÄTSWOCHE (kurz EMW) ist eine Kampagne der Europäischen Kommission. Jedes Jahr vom 16. bis 22. September bietet sie Kommunen aus ganz Europa die perfekte Möglichkeit, ihren Bürgerinnen und Bürgern die komplette Bandbreite nachhaltiger Mobilität vor Ort näher zu bringen. Der neue EMW-Leitfaden 2019 für Deutschland fasst auf 36 Seiten alle wichtigen Informationen rund um die EMW zusammen und bietet außerdem durch 18 neue Praxisbeispiele aus Deutschland und dem europäischen Ausland Inspirationen für die eigene Teilnahme.
title: Variantes Anatómicas de la Arteria Hepática. Frecuencia en Nuestro Medio y Correlación Radio-Quirúrgica.
Creators: name: Pérez Durán, Arlene
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Anatomy

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
En la cirugía abdominal superior es fundamental un conocimiento detallado de la vascularización arterial hepática.
Por ello,
el estudio radiológico preoperatorio debe proporcionar una descripción precisa de la vascularización regional,
tanto...
Extending the nearby galaxy heritage with WISE: first results from the WISE Enhanced Resolution Galaxy Atlas
Creators: name: Jarrett, T. H.
name: Masci, F.
name: Tsai, C. W.
name: Petty, S.
name: Cluver, Michelle
name: Assef, Roberto J.
name: Benford, D.
name: Blain, A.
name: Bridge, C.
name: Donoso, E.
name: Eisenhardt, P.
name: Koribalski, B.
name: Lake, S.
name: Neill, James D.
name: Seibert, M.
name: Sheth, K.
name: Stanford, S.
name: Wright, E.
Publisher: name: Swinburne
Year: 2024

description: The Wide-field Infrared Survey Explorer (WISE) mapped the entire sky at mid-infrared wavelengths 3.4 μm, 4.6 μm, 12 μm, and 22 μm. The mission was primarily designed to extract point sources, leaving resolved and extended sources, for the most part, unexplored. Accordingly, we have begun a dedicated WISE Enhanced Resolution Galaxy Atlas (WERGA) project to fully characterize large, nearby galaxies and produce a legacy image atlas and source catalog. Here we demonstrate the first results of the WERGA project for a sample of 17 galaxies, chosen to be of large angular size, diverse morphology, and covering a range in color, stellar mass, and star formation. It includes many well-studied galaxies, such as M 51, M 81, M 87, M 83, M 101, and IC 342. Photometry and surface brightness decomposition is carried out after special super-resolution processing, achieving spatial resolutions similar to that of Spitzer Infrared Array Camera. The enhanced resolution method is summarized in the first paper of this two-part series. In this second work, we present WISE, Spitzer, and Galaxy Evolution Explorer (GALEX) photometric and characterization measurements for the sample galaxies, combining the measurements to study the global properties. We derive star formation rates using the polycyclic aromatic hydrocarbon sensitive 12 μm (W3) fluxes, warm-dust sensitive 22 μm (W4) fluxes, and young massive-star sensitive ultraviolet (UV) fluxes. Stellar masses are estimated using the 3.4 μm (W1) and 4.6 μm (W2) measurements that trace the dominant stellar mass content. We highlight and showcase the detailed results of M 83, comparing the WISE/Spitzer results with the Australia Telescope Compact Array H I gas distribution and GALEX UV emission, tracing the evolution from gas to stars. In addition to the enhanced images, WISE's all-sky coverage provides a tremendous advantage over Spitzer for building a complete nearby galaxy catalog, tracing both stellar mass and star formation histories. We discuss the construction of a complete mid-infrared catalog of galaxies and its complementary role of studying the assembly and evolution of galaxies in the local universe.
PRA1 and synaptotagmin VIII: Regulators of vesicle trafficking and fusion
Creators: name: Hutt, Darren
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Neuroscience.

description: The work described within my doctoral thesis examines the localization and functional role of the prenylated Rab acceptor 1 (PRA1) in the Rab GTPase cycle and the expression, localization and functional role of synaptotagmin VIII in the mouse sperm acrosome reaction. My work began with the examination of both PRA1 and synaptotagmin VIII. The PRA1 project was taken over by other graduate students while my interests remained focused on elucidating the role of synaptotagmin VIII in sperm. Rab is a family of small Ras-like GTPases regulating intracellular vesicle transport. Prenylated Rab Acceptor (PRA1) has previously been shown to interact with Rab GTPases and VAMP2. I have examined the subcellular localization of PRA1 and examined the functional significance of its interaction with Rab3A. PRA1 is localized to the Golgi complex while truncation of the carboxy-terminus results in a mislocalization to the ER. I also observed that PRA1 is able to bind weakly to GDP dissociation inhibitor (GDI), a protein involved in the solubilization of membrane-bound Rab GTPases. Furthermore, the addition of PRA1 inhibited the extraction of membrane-bound Rab3A by GDI, suggesting that membrane localization of Rab GTPases is dependent on the opposing action of PRA1 and GDI. The sperm acrosome is a large secretory granule that undergoes calcium-stimulated exocytosis by a mechanism analogous to neuronal secretion. In neurons, the core SNARE complex, composed of syntaxin (Stx), SNAP-25 and VAMP2, mediates vesicle fusion, while calcium regulation is thought to be accomplished by the synaptotagmin (Syt) family via calcium-dependent binding to syntaxin and SNAP-25. I examined the expression, localization and function of Syt VIII in mouse sperm. I found that Syt VIII is expressed in spermatozoa and localizes to the acrosome. In addition, the introduction of Syt VIII antibodies and recombinant protein into Streptolysin O permeabilized sperm, resulted in inhibition of the acrosome reaction (AR), suggesting a critical function for this protein. Syt VIII also exhibited Ca2+-dependent binding to Stx2 with an EC50 that closely matches the calcium requirement of the AR. Taken together, our data suggest a critical role for Syt VIII and Stx2 in the acrosome reaction.
title: Resonancia Magnetica de cuerpo entero en el estudio de las miopatías.
Creators: name: Guisasola Iñiguez, Amaia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Musculoskeletal system
subject: Musculoskeletal soft tissue
subject: Extremities

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
El objetivo de este póster es mostrar la utilidad de la RM de cuerpo entero en el estudio de las...
title: Interaction of Age and Mechanical Stability on Bone Defect Healing
title: An Early Transcriptional Analysis of Fracture Hematoma in Rat
titleType: Subtitle
Creators: name: Ode, Andrea
name: Duda, Georg N.
name: Geissler, Sven
name: Pauly, Stephan
name: Ode, Jan-Erik
name: Perka, Carsten
name: Strube, Patrick
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Among other stressors, age and mechanical constraints significantly influence regeneration cascades in bone healing. Here, our aim was to identify genes and, through their functional annotation, related biological processes that are influenced by an interaction between the effects of mechanical fixation stability and age. Therefore, at day three post-osteotomy, chip-based whole- genome gene expression analyses of fracture hematoma tissue were performed for four groups of Sprague-Dawley rats with a 1.5-mm osteotomy gap in the femora with varying age (12 vs. 52 weeks - biologically challenging) and external fixator stiffness (mechanically challenging). From 31099 analysed genes, 1103 genes were differentially expressed between the six possible combinations of the four groups and from those 144 genes were identified as statistically significantly influenced by the interaction between age and fixation stability. Functional annotation of these differentially expressed genes revealed an association with extracellular space, cell migration or vasculature development. The chip-based whole-genome gene expression data was validated by q-RT-PCR at days three and seven post-osteotomy for MMP-9 and MMP-13, members of the mechanosensitive matrix metalloproteinase family and key players in cell migration and angiogenesis. Furthermore, we observed an interaction of age and mechanical stimuli in vitro on cell migration of mesenchymal stromal cells. These cells are a subpopulation of the fracture hematoma and are known to be key players in bone regeneration. In summary, these data correspond to and might explain our previously described biomechanical healing outcome after six weeks in response to fixation stiffness variation. In conclusion, our data highlight the importance of analysing the influence of risk factors of fracture healing (e.g. advanced age, suboptimal fixator stability) in combination rather than alone.
Role of interleukin-12 and interleukin-18 in murine immune cell regulation
Creators: name: Chakir, Habiba
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Health Sciences, Immunology.

description: Interleukin 12 plays a central role in NK cell activation and CD4 +T cell differentiation. IL-12 acts via a receptor composed of IL-12Rbeta1 and IL-12Rbeta2 subunits. IL-12Rbeta1 plays a primary role in ligand binding whereas IL-12Rbeta2 is responsible for signaling. IL-18 shares some functional activities of IL-12. However, there is a considerable amount of contradictory data in the literature regarding the requirements for IL-12 and IL-18 responsiveness. This work examined the expression of IL-12Rbeta2 on murine NK and T cells and the requirements for acquisition of IL-12/IL-18 responsiveness. NK cells stimulated with IL-2+IL-12 or IL-2+IL-18 exhibited rapid upregulation of IFN-gamma expression followed by upregulation of IL-10 or IL-13 mRNA, respectively. NK cells from IL-12Rbeta2-deficient mice responded to IL-2+IL-18 independently of IL-12. Furthermore, flow cytometric analyses revealed that NK cells activated in vitro with IL-2 differentiate into two distinct cell subsets expressing different levels of IL-12Rbeta2. Like NK cells, NK-T cells also responded to IL-2+IL-12 or IL-2+IL-18 without stimulation of the antigen-specific T cell receptor (TCR). Previously, it was thought that all T cells require activation via the TCR in order to respond to IL-12 or IL-18. Thus, responsiveness of conventional T cells to IL-2+IL-12 or IL-2+IL-18 in the absence of TCR ligation was assessed. Naive CD4+T cells from wild type or DO11.10/Rag2-/- OVA-specific TCR transgenic mice responded to IL-2+IL-12 or IL-2+IL-18 by expressing IFN-gamma and cells grown in IL-2+IL-12 exhibited signs of polarization towards a TH1 phenotype. Transgenic BALB/c mice constitutively expressing the IL-12Rbeta2 chain were generated and the role of the IL-12Rbeta2 in TH2 phenotype development was analyzed using the TH1-dependent murine leishmaniasis model. Despite constitutive expression of the IL-12Rbeta2 chain, transgenic TH2 cells did not revert to TH1 when restimulated with IL-12 and mice remained susceptible to Leishmania. The role of IL-12Rbeta2 in TH1 cell development was also analyzed using the same model. Resistant C57BL/6 mice defective in IL-12Rbeta2 gene exhibited susceptibility to L. major infection and expressed a T H2 phenotype, consistent with a critical role for IL-12 in this model. Thus understanding the expression of IL-12Rbeta2 in NK and CD4 +T cells and its regulation by cytokines may constitute an important element in studies in cancer and autoimmune disease therapy.
Differences in signal activation by LH and hCG are mediated by the LH/CG receptor’s extracellular hinge region
Creators: name: Grzesik, Paul
name: Kreuchwig, Annika
name: Rutz, Claudia
name: Furkert, Jens
name: Wiesner, Burkhard
name: Schuelein, Ralf
name: Kleinau, Gunnar
name: Gromoll, Joerg
name: Krause, Gerd
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: lutropin receptor
subject: GPCR activation
subject: lutropin
subject: choriogonadotropin
subject: glycoprotein hormone receptor
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The human lutropin (hLH)/choriogonadotropin (hCG) receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) – secreted by the placenta, and lutropin (LH) – produced by the pituitary. They induce different signaling profiles at the LHCGR. This cannot be explained by binding to the receptor’s leucine-rich- repeat domain (LRRD), as this binding is similar for the two hormones. We therefore speculate that there are previously unknown differences in the hormone/receptor interaction at the extracellular hinge region, which might help to understand functional differences between the two hormones. We have therefore performed a detailed study of the binding and action of LH and CG at the LHCGR hinge region. We focused on a primate-specific additional exon in the hinge region, which is located between LRRD and the serpentine domain. The segment of the hinge region encoded by exon10 was previously reported to be only relevant to hLH signaling, as the exon10-deletion receptor exhibits decreased hLH signaling, but unchanged hCG signaling. We designed an advanced homology model of the hormone/LHCGR complex, followed by experimental characterization of relevant fragments in the hinge region. In addition, we examined predictions of a helical exon10-encoded conformation by block-wise polyalanine (helix supporting) mutations. These helix preserving modifications showed no effect on hormone-induced signaling. However, introduction of a structure-disturbing double-proline mutant LHCGR-Q303P/E305P within the exon10-helix has, in contrast to exon10-deletion, no impact on hLH, but only on hCG signaling. This opposite effect on signaling by hLH and hCG can be explained by distinct sites of hormone interaction in the hinge region. In conclusion, our analysis provides details of the differences between hLH- and hCG-induced signaling that are mainly determined in the L2-beta loop of the hormones and in the hinge region of the receptor.
Acute care and emergency general surgery in patients with chronic liver disease: how can we optimize perioperative care? A review of the literature
Creators: name: Bleszynski, Michael S
name: Bressan, Alexsander K
name: Joos, Emilie
name: Morad Hameed, S.
name: Ball, Chad G
Publisher: name: BioMed Central
Year: 2018

description: The increasing prevalence of advanced cirrhosis among operative candidates poses a major challenge for the acute care surgeon. The severity of hepatic dysfunction, degree of portal hypertension, emergency of surgery, and severity of patients’ comorbidities constitute predictors of postoperative mortality. Comprehensive history taking, physical examination, and thorough review of laboratory and imaging examinations typically elucidate clinical evidence of hepatic dysfunction, portal hypertension, and/or their complications. Utilization of specific scoring systems (Child-Pugh and MELD) adds objectivity to stratifying the severity of hepatic dysfunction. Hypovolemia and coagulopathy often represent major preoperative concerns. Resuscitation mandates judicious use of intravenous fluids and blood products. As a general rule, the most expeditious and least invasive operative procedure should be planned. Laparoscopic approaches, advanced energy devices, mechanical staplers, and topical hemostatics should be considered whenever applicable to improve safety. Precise operative technique must acknowledge common distortions in hepatic anatomy, as well as the risk of massive hemorrhage from porto-systemic collaterals. Preventive measures, as well as both clinical and laboratory vigilance, for postoperative hepatic and renal decompensation are essential.
Enhanced warm H2 emission in the compact group mid-infrared "green valley"
Creators: name: Cluver, Michelle
name: Appleton, P. N.
name: Ogle, P.
name: Jarrett, T. H.
name: Rasmussen, J.
name: Lisenfeld, U.
name: Guillard, P.
name: Verdes-Montenegro, L.
name: Antonucci, R.
name: Bitsakis, T.
name: Charmandaris, V.
name: Boulanger, F.
name: Egami, E.
name: Xu, C. K.
name: Yun, M. S.
Publisher: name: Swinburne
Year: 2024

description: We present results from a Spitzer mid-infrared spectroscopy study of a sample of 74 galaxies located in 23 Hickson Compact Groups (HCGs), chosen to be at a dynamically active stage of H I depletion. We find evidence for enhanced warm H2 emission (i.e., above that associated with UV excitation in star-forming regions) in 14 galaxies (~20%), with 8 galaxies having extreme values of L(H2 S(0)-S(3))/L(7.7 μm polycyclic aromatic hydrocarbon), in excess of 0.07. Such emission has been seen previously in the compact group HCG 92 (Stephan's Quintet), and was shown to be associated with the dissipation of mechanical energy associated with a large-scale shock caused when one group member collided, at high velocity, with tidal debris in the intragroup medium. Similarly, shock excitation or turbulent heating is likely responsible for the enhanced H2 emission in the compact group galaxies, since other sources of heating (UV or X-ray excitation from star formation or active galactic nuclei) are insufficient to account for the observed emission. The group galaxies fall predominantly in a region of mid-infrared color-color space identified by previous studies as being connected to rapid transformations in HCG galaxy evolution. Furthermore, the majority of H2-enhanced galaxies lie in the optical "green valley" between the blue cloud and red sequence, and are primarily early-type disk systems. We suggest that H2-enhanced systems may represent a specific phase in the evolution of galaxies in dense environments and provide new insight into mechanisms which transform galaxies onto the optical red sequence.