cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: Table S1. of BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer
Creators: name: Weber-Lassalle, Nana
name: Hauke, Jan
name: Ramser, Juliane
name: Richters, Lisa
name: Groß, Eva
name: Blümcke, Britta
name: Gehrig, Andrea
name: Anne-Karin Kahlert
name: Müller, Clemens
name: Hackmann, Karl
name: Honisch, Ellen
name: Weber-Lassalle, Konstantin
name: Niederacher, Dieter
name: Borde, Julika
name: Thiele, Holger
name: Ernst, Corinna
name: Altmüller, Janine
name: Neidhardt, Guido
name: Nürnberg, Peter
name: Klaschik, Kristina
name: Schroeder, Christopher
name: Platzer, Konrad
name: Volk, Alexander
name: Wang-Gohrke, Shan
name: Just, Walter
name: Auber, Bernd
name: Kubisch, Christian
name: Schmidt, Gunnar
name: Horvath, Judit
name: Wappenschmidt, Barbara
name: Engel, Christoph
name: Arnold, Norbert
name: Dworniczak, Bernd
name: Rhiem, Kerstin
name: Meindl, Alfons
name: Schmutzler, Rita
name: Hahnen, Eric
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Inclusion criteria of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) for BRCA1 and BRCA2 germline testing. Table S2. Heterozygous protein-truncating mutations identified in the BRIP1 gene. Figure S1. Characterization of the c.507G > A variant within the BRIP1 gene (rs876660937) on transcript level. Table S3. Genotypes and phenotypes of heterozygous BRIP1 mutation carriers identified within the BC/OC index patient cohorts. Table S4. Potentially damaging missense variants identified in the BRIP1 gene. (PDF 215 kb)
(RS27) Evaluation of Spironolactone Use and the Effects on Left Ventricle Ejection Fraction Among Chronic Heart Failure Patients in Hospital Kuala Lumpur: A Retrospective Observational Cohort Study.
Creators: name: Jivanraj R Nagarajah
Publisher: name: Zenodo
Year: 2022

description: Introduction: Spironolactone has been indicated in managing patients with heart failure with reduced left ventricle ejection fraction (LVEF). Randomized Aldactone Evaluation Study (RALES) 1999 showed that spironolactone reduces all-cause mortality rate in heart failure patients. Despite that, ASIAN HF registry 2018 shows that only 58% of patients with LVEF <35% were on spironolactone. Results and discussion : 95 patients were included with 46 patients (48.4%) on spironolactone and 49 patients (51.6%) who were not. Common factors for not starting spironolactone include asymptomatic patient (35%), preexisting hyperkalemia (23%), low blood pressure and renal impairment (8% for both). Only three patient developed spironolactone-related hyperkalemia throughout one year of spironolactone treatment and no other adverse effects were observed. LVEF outcome in patients was improved after one year on spironolactone add on therapy, which from average baseline LVEF of 27.5±5.4% during the first visit to clinic to an average LVEF of 37.2±10.4% (P<0.0001; 95% CI 6.4, 12.9). However, when LVEF differences were compared between patients receiving spironolactone and those who did not, no significant differences were found after one year of treatment (P<0.901). Conclusion : Initiation of spironolactone are determined by many factors such as the presence of pre-existing hyperkalaemia, and low blood pressure. Although addition of spironolactone did improve LVEF outcome, the improvement cannot be compared with patients ACEi /ARBs and beta blockers alone in this study.
Additional file 1 of The effectiveness and acceptability of evidence synthesis summary formats for clinical guideline development groups: a mixed-methods systematic review
Creators: name: Sharp, Melissa K.
name: Baki, Dayang Anis Binti Awang
name: Quigley, Joan
name: Tyner, Barrie
name: Devane, Declan
name: Mahtani, Kamal R.
name: Smith, Susan M.
name: O’Neill, Michelle
name: Ryan, Máirín
name: Clyne, Barbara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. PRISMA checklist.
Breaking the 3/2 barrier for unit distances in three dimensions
Creators: name: Zahl, Joshua
Publisher: name: arXiv
Year: 2017
Subjects: subject: Metric Geometry (math.MG)
subject: Computational Geometry (cs.CG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We prove that every set of $n$ points in $\mathbb{R}^3$ spans $O(n^{295/197+ε})$ unit distances. This is an improvement over the previous bound of $O(n^{3/2})$. A key ingredient in the proof is a new result for cutting circles in $\mathbb{R}^3$ into pseudo-segments.
description: 44 pages, 0 figures. v3: This version fixes an error in the proof of Lemma 3.2 that was pointed out by Micha Sharir. The rest of the paper remains unchanged
Additional file 2 of The effectiveness and acceptability of evidence synthesis summary formats for clinical guideline development groups: a mixed-methods systematic review
Creators: name: Sharp, Melissa K.
name: Baki, Dayang Anis Binti Awang
name: Quigley, Joan
name: Tyner, Barrie
name: Devane, Declan
name: Mahtani, Kamal R.
name: Smith, Susan M.
name: O’Neill, Michelle
name: Ryan, Máirín
name: Clyne, Barbara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Search strategy results.
Additional file 1 of Association between overall dietary quality and constipation in American adults: a cross-sectional study
Creators: name: Liu, Qingye
name: Kang, Yulong
name: Yan, Jin
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary Material 1
Systèmes territoriaux d'innovation, source de compétitivité et de résilience des territoires
Creators: name: MAMOUNI ALAOUI, Charifa
name: EDDELANI, Oumhani
Publisher: name: Zenodo
Year: 2024
Subjects: Innovation territoriale ; Compétitivité ; Proximité ; Acteurs locaux ; Gouvernance

description: Dans un contexte international en profonde mutation, une nouvelle façon de reconnaître les réalités des territoires, nécessite un soutien à l’innovation répondant aux exigences et aux défis de la mondialisation. Dès lors, il est légitime de renouveler les réflexions sur l’autonomie des territoires, d’où la nécessité d’opérer un choix clair en faveur de la compétitivité des territoires. Et cela, à travers une politique de création d’une économie en réseau pour redynamiser les régions, basée sur des spécificités locales.

En raison de ce renouvellement, des configurations territoriales fondées sur la concentration géographique de divers intervenants ont vu le jour, et des effets de la dimension spatiale ont été ressentis, offrant aux acteurs locaux une capacité d'adaptation.

Cette étude se veut exploratoire. Elle repose sur une démarche qualitative qui vise à explorer les Systèmes Territoriaux d’Innovation (STI), par les liens qu’ils tissent en leur sein, leur recherche permanente d’innovation, leur ouverture sur l’extérieur, offrent une réponse adaptée. L’étude présente dans cet esprit le cas de la région de Fès-Meknès qui offrent une compréhension des réalités vécues sur le terrain par ces systèmes d’innovation, leur intérêt s’est affirmé tant au Nord qu’au Sud surtout pour les pays en développement comme le Maroc.
Patient biochemistry and treatment need in chronic hepatitis B virus infection across three continents: retrospective cross-sectional cohort studies.
Creators: name: Gillespie, Iain A
name: Barnes, Eleanor
name: Wong, Ian CK
name: Matthews, Philippa C
name: Cooke, Graham S
name: Tipple, Craig
name: Elston, Robert C
name: Liu, Yunhao
name: Smith, David A
name: Wang, Tingyan
name: Davies, Jim
name: Várnai, Kinga A
name: Freeman, Oliver
name: Man, Kenneth KC
name: Lau, Wallis CY
name: Glampson, Ben
name: Meng, Xing
name: Morais, Eleonora
name: Liu, Sen
name: Mercuri, Luca
name: Boxall, Naomi
name: Jenner, Sarah
name: Kendrick, Stuart
name: Dong, Jane
name: Theodore, Dickens
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: classificationCode: Infectious Disease
subject: Infectious Disease
classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: Genetics & Genomics
subject: Genetics & Genomics

description: INTRODUCTION: Chronic hepatitis B virus (HBV) infection is associated with significant global morbidity and mortality. Low treatment rates are observed in patients living with HBV; the reasons for this are unclear. This study sought to describe patients' demographic, clinical and biochemical characteristics across three continents and their associated treatment need. METHODS: This retrospective cross-sectional post hoc analysis of real-world data used four large electronic databases from the United States, United Kingdom and China (specifically Hong Kong and Fuzhou). Patients were identified by first evidence of chronic HBV infection in a given year (their index date) and characterized. An algorithm was designed and applied, wherein patients were categorized as treated, untreated but indicated for treatment and untreated and not indicated for treatment based on treatment status and demographic, clinical, biochemical and virological characteristics (age; evidence of fibrosis/cirrhosis; alanine aminotransferase [ALT] levels, HCV/HIV coinfection and HBV virology markers). RESULTS: In total, 12,614 US patients, 503 UK patients, 34,135 patients from Hong Kong and 21,614 from Fuzhou were included. Adults (99.4%) and males (59.0%) predominated. Overall, 34.5% of patients were treated at index (range 15.9-49.6%), with nucleos(t)ide analogue monotherapy most commonly prescribed. The proportion of untreated-but-indicated patients ranged from 12.9% in Hong Kong to 18.2% in the UK; almost two-thirds of these patients (range 61.3-66.7%) had evidence of fibrosis/cirrhosis. A quarter (25.3%) of untreated-but-indicated patients were aged ≥ 65 years. CONCLUSION: This large real-world dataset demonstrates that chronic hepatitis B infection remains a global health concern; despite the availability of effective suppressive therapy, a considerable proportion of predominantly adult patients apparently indicated for treatment are currently untreated, including many patients with fibrosis/cirrhosis. Causes of disparity in treatment status warrant further investigation.
Additional file 1: Figure S1. of ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systems
Creators: name: Thomas, Dennis
name: Smith, Jordan
name: Thrall, Brian
name: Baer, Donald
name: Jolley, Hadley
name: Prabhakaran Munusamy
name: Vamsi Kodali
name: Demokritou, Philip
name: Cohen, Joel
name: Teeguarden, Justin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Model predictions of total dissolved silver for different initial concentrations of free and bound ions and 12.5 μg/mL particle concentration in RPMI + 1% (a), 10% (b) and 30% (c) FBS. Figure S2. Collinearity of parameters (in log10 scale) as a function of the number of parameters selected. Figure S3. Sensitivity range of model predictions for total dissolved silver to each parameter of the model, while keeping the other parameters fixed at their fitted values. Figure S4. Sensitivity range of model predictions for total dissolved silver concentration for 12.5 μg/ml particle concentration in RPMI + 1% (a), 10% (b) and 30% (c) FBS, to 10% change in all parameters. Figure S5. Number of particles in the liquid media as a function particle diameter (Dp) at selected time points from 0.024 to 24 h, starting with: a) 12.5 μg/mL concentration of 20 nm particles; and, b) 9.15 μg/mL concentration of 110 nm particles. Figure S6. Péclet number as a function particle diameter (Dp) based on particle densities, 1.583 g/cm3 (20 nm system) (a) and 1.914 g/cm3 (110 nm system) (b). Figure S7. Effect of changing the lower limit for the particle size from 10 nm to 2 nm (due to dissolution) in the 20 nm system with an initial concentration of 1 μg/mL: (a) Particle number density versus particle diameter. Figure S8. Negative results showing the effect of dissolution on the percentage dose of silica in cells (a) and in the liquid media (b), using silver dissolution kinetics. Figure S9. Effect of increasing the cell’s resistance to particle uptake on deposited mass of silver for 20 nm particles, by varying the parameter K from 0 to 0.05. (PDF 1772 kb)
The Role of Physical, Cognitive, and Interpersonal Occupational Requirements and Working Conditions on Disability and Retirement
Creators: name: Garcia, Italo Lopez
name: Mullen, Kathleen J.
name: Wenger, Jeffrey B.
Publisher: name: My University
Year: 2022
Subjects: subject: job demands, occupational requirements survey, retirement, disability status
subject: Population and Demography
subject: Social Sciences

description: We examine of the role of physical and mental job requirements, as well as hazardous working conditions, on retirement and disability among older individuals in the United States. By linking occupation-level data on job requirements from the Occupational Requirements Survey (ORS) to individual-level data from the Health and Retirement Study (HRS), we create composite indices for physical activities and the physical work environment, as well as two indices of mental job requirements related to job autonomy and flexibility index, and being supervised and working with the pubic. Using data from the HRS Life History Mail Survey, we merge these indices to the HRS panel using the most important occupation held by the individual in her prime years. We find that a 1 standard deviation (SD) increase in the physical activity and physical work environment indices are associated with a 10 to 13 percentage point (pp) increase in the probability of being retired and a 3 to 5 pp increase in the probability of transitioning into retirement. The associations of these indices with disability outcomes follow the same patterns as retirement, but they are lower in magnitude. A 1 SD increase in job autonomy/flexibility is associated with a 22 pp decrease in the probability of being retired and a 12 pp decrease in retirement transitions, but it does not predict disability outcomes. Finally, the effects of physically demanding and hazardous jobs on labor force exit are concentrated among men and low-educated workers, while delays in retirement predicted by higher job autonomy and flexibility are driven by college-educated workers.
DSS validation
Creators: name: Panunzi, Simona
name: Guerri, Marco
name: Karlsson, Patrik
name: Angelidis, Christos
name: Kallia Angelaki
Publisher: name: Zenodo
Year: 2021
Subjects: DSS
Validation

description: The aim of the present deliverable is to present the DSS validation framework, in all its steps, from the software verification to the establishment of a panel of experts identifying possible shortcomings or further user requirements that the stakeholders would declare to be necessary.
 Several scenarios (simulated Uses Cases, described in Section 4) will illustrate the potentiality and usefulness of the S&R DSS platform from a user perspective. The proposed simulated Use Cases will be the object of the upcoming tabletop demonstration (the first one taking place before the execution of the real S&R Use Case 1: Victims trapped under the rubble, Italy).
 The simulated Use Case Scenarios of Section 4 will therefore have the purpose to show all the DSS features implemented in the first version; feedback gathered from the panel of experts will help to fill the existing gaps to create an improved subsequent version of the component.
 The present document also shows the way the DSS will be validated in the scheduled real S&R Use Cases and will provide a series of benchmarks against which the performance of DSS will be measured in a real situation. A User/Observer questionnaire will be adopted as a further instrument of validation.
 The document is structured in the following Sections: in Section 2, Methodology, a background to a DSS validation approach is presented, with the description of the procedure set up for the establishment of the panel of experts. Section 3 presents a detailed description of the software verification; Section 4 presents the simulated Use Cases foreseen for the tabletop demonstration and Section 5 gives an overview of the real S&R Use Cases where the DSS will be validated with the presentation of the User
 /Observer questionnaire which will be administered at the end of the real demonstrations.
 Finally, Section 6, Conclusions, summarizes the results achieved and their usefulness in relationship with future work to be performed.
(RS28) Comparison of Models for the Prediction of Death Among Severe Dengue Cases by Statistical and Machine Learning Algorithms
Creators: name: Saiful Safuan Md Sani
Publisher: name: Zenodo
Year: 2022

description: Introduction: Many studies built predictive models to predict dengue outbreaks, identify dengue and stratify dengue, but none has predicted death in severe dengue cases. Results and discussion: The basic logistic regression model had a c-statistic (also area under the receiver operating characteristic curve) of 85.3%, sensitivity of 28.7% and rescaled Brier score of 0.32. A stepwise logistic regression model had a c-statistic of 86.2%, sensitivity of 24.5% and rescaled Brier 0.29. The two best performing models with the highest c-statistic were a rule based C5.0 decision tree, 89.5% and a naive Bayes model, 89.1%. The two most sensitive models were the naive Bayes model, 50.3%, and the logistic regression model. The two best performing models with the highest rescaled Brier were a random forest model, 0.88, and a C5.0 rule-based decision tree, 0.65. Conclusion: Quantifying the risk of death and its prediction justify intensifying clinical management and aggressive treatment.
Additional File 1:
Creators: name: Nitika Sanger
name: Meha Bhatt
name: Zielinski, Laura
name: Sanger, Stephanie
name: Hamnah Shahid
name: Bantoto, Bianca
name: M.Constantine Samaan
name: Souza, Russell De
name: Samaan, Zainab
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Data extraction form in. This form includes all the information we intend to extract from the included studies. (PDF 54Â kb)
The TRAPUM Survey for New Gamma-ray Pulsars
Creators: name: Clark, Colin
Publisher: name: Zenodo
Year: 2024

description: One major goal of the TRAPUM Large Survey Project is to use MeerKAT to discover new millisecond pulsars by targeting unidentified GeV gamma-ray sources detected by the Fermi Large Area Telescope (LAT). This sub-project has now discovered more than 30 new pulsars through short, repeated observations of around 150 Fermi-LAT sources. In this talk, I will describe our ongoing survey, and present highlights from among these new discoveries, many of which are in exotic, short-period ``spider'' binaries, whose discovery rate has been significantly boosted by MeerKAT's exceptional sensitivity. MeerKAT's unique capabilities provide us with sub-arcsecond localisations for our new discoveries, enabling rapid identification of multi-wavelength counterparts to follow up, and easing the process of obtaining full timing solutions and detecting gamma-ray pulsations. I will explain how this allows us to maximise the scientific potential of our new discoveries, with goals ranging from constraining the neutron star equation-of-state with new pulsar-mass measurements, to providing new sources for pulsar timing array projects, and even searching for continuous gravitational waves from our new pulsars in archival detector data.
Additional file 4 of The effectiveness and acceptability of evidence synthesis summary formats for clinical guideline development groups: a mixed-methods systematic review
Creators: name: Sharp, Melissa K.
name: Baki, Dayang Anis Binti Awang
name: Quigley, Joan
name: Tyner, Barrie
name: Devane, Declan
name: Mahtani, Kamal R.
name: Smith, Susan M.
name: O’Neill, Michelle
name: Ryan, Máirín
name: Clyne, Barbara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4. Quantitative findings.
Diversity of threatened medicinal plants of Indian Himalayan Region
Creators: name: Mehta, Poonam
name: Bisht, Kapil
name: Sekar, K. Chandra
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology
subject: 60506 Virology

description: Medicinal and aromatic plants (MAPs) are frequently being used for various ailments since time immemorial by a vast range of human communities. The Indian Himalayan Region (IHR), which forms part of one of the 36 global biodiversity hotspots, is known for its rich and unique biodiversity elements. In last decades, plant-based medicines have gained popularity over synthetic pharmaceutical products as they are retained less harmful. However, increased demand of these plant-based medicinal products has caused over-harvesting, unmonitored trade, habitat destruction and anthropogenic pressure on MAPs. In view of their importance, the present study aims to document the diversity of threatened plants in IHR that are medicinally important, their distribution in 12 Himalayan states and suggest conservation measures. A total of 112 plant species were documented of which 19 species were found to be in high-risk categories viz. critically endangered (seven), endangered (seven) and vulnerable (five) as per IUCN. Distribution, life-forms, medicinal values, plant parts used, threat categories, population trends, market value and conservation approaches of the species are also presented. The study strongly recommends prohibition of unmanaged extraction of medicinally important threatened plants from the wild and encourages their cultivation.
(CR1) The Forgotten Tetanus and Role of Magnesium Infusion in Managing Generalised Tetanus
Creators: name: Roslan, Nurul Liana
Publisher: name: Zenodo
Year: 2022

description: Introduction: Tetanus is a syndrome of acute painful muscular spasm with autonomic dysfunction. The diagnosis often delayed as it is rare, especially in urban settlement; until the manifestation become overt. We report a case of localised tetanus which subsequently became generalised tetanus. Case Presentation: 35-year-old gentlemen presented with generalised muscle spasm, progressive dysphagia, and intermittent fever. He had a wound over his right limb a week prior following a fall. Three days earlier, he presented with abdominal pain but was discharged. On examination, neck stiffness, trismus and risus sardonicus was observed with evidence of autonomic dysfunction. Human tetanus immunoglobulin, tetanus toxoid, metronidazole and diazepam were instituted promptly. Magnesium sulphate therapy was initiated to avoid intubation and control the dysautonomia. Patient was admitted to the high dependency unit and discharged well after 3 weeks without intubation. Conclusion: Clinical tetanus (generalized, local, and cephalic) can cause autonomic dysfunction and hyper sympathetic reactions. The principle of treating tetanus is reducing muscle spasm and rigidity, autonomic instability, neutralization of tetanospasmin, wound debridement and administration of antibiotic to eradicate locally proliferating bacteria at the wound site. Emergency physician needs to be cognizant of the unique presentation of tetanus. Early administration of magnesium sulphate has been proven to avoid intubation in severe tetanus. A standardized protocol for the treatment of tetanus related dysautonomia need to be further studied.
Plant growth promoting potential of bacterial endophytes from three terrestrial mediterranean orchid species
Creators: name: Alibrandi, Pasquale
name: Monaco, Nicolò Lo
name: Calevo, Jacopo
name: Voyron, Samuele
name: Puglia, Anna Maria
name: Cardinale, Massimiliano
name: Perotto, Silvia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Orchids are highly dependent on symbiotic microorganisms during their entire life cycle. Whereas an important role in orchid seed germination and early plant development is well established for mycorrhizal fungi, the influence of endophytic bacteria on orchid growth has been less investigated. Here, we report the isolation of endophytic bacteria from different organs of three terrestrial Mediterranean orchid species (Spiranthes spiralis, Serapias vomeracea and Neottia ovata), the investigation of their potential Plant Growth-Promoting (PGP) traits and their interaction with the orchid mycorrhizal (OM) fungus Tulasnella calospora in vitro. Little overlap was found among endophytic bacteria isolated from the different organs of the three orchid species. Taxonomic identification, based on the 16S rRNA gene, of fifty dereplicated bacterial isolates revealed that they belong to the genera Pseudomonas, Pantoea, Rahnella, Staphylococcus, Sphingomonas, Microbacterium, Streptomyces, Fictibacillus and Bacillus. Most bacterial isolates exhibited some potential PGP traits, such as nutrient solubilization, ACC deaminase activities and/or IAA biosynthesis. Although some Pseudomonas reduced growth of the OM fungus Tulasnella calospora, most isolates did not affect fungal growth. These results increase our understanding of the diversity and potential PGP functions of bacterial endophytes in terrestrial orchids, and suggest a role as beneficial partners in the orchid microbiota.
Additional file 1: of Factors associated with the use of dietary supplements and over-the-counter medications in Japanese elderly patients
Creators: name: Masumoto, Shoichi
name: Mikiya Sato
name: Takami Maeno
name: Ichinohe, Yumiko
name: Maeno, Tetsuhiro
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Factors associated with the use of dietary supplements and OTC drugs (subgroup analyses). Logistic regression analyses were conducted for assessing factors associated with the use of dietary supplements and OTC drugs. (DOCX 23 kb)
Partial or complete replacement of soybean meal with black soldier fly larvae meal improves feed efficiency in laying hens between 22 to 30 weeks of age
Creators: name: Veldkamp, T.
name: Rezaei Far, A.
name: Caimi, C.
name: Gasco, L.
name: Lima, R.C.
name: Cunha, L.M.
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 309999
subject: Other agricultural, veterinary and food sciences not elsewhere classified

description: The European Commission recently authorised the inclusion of insect meal in poultry feed. Black soldier fly larvae meal (BSF) has comparable nutritional value to soybean meal (SBM) and higher calcium content, making it an attractive alternative protein source for laying hens While a few studies have explored this objective, inconsistent results have been reported, likely due to variations in hen age, breed, husbandry systems, and sunflower meal composition across studies, making it difficult to draw clear conclusions . We hypothesised that partial or complete replacement of SBM with BSF has no adverse effects on egg production and quality in laying hens at the initiation of laying (22-30 weeks of age). This study consisted of three dietary treatments and nine replicates per treatment. Diets were a control diet, and two diets containing 5% (BSF5%) and 10% (BSF10%). The experimental unit was a pen (100 × 200 × 200 cm) of 14 Brown Nick laying hens resembling an aviary setting. We found that complete replacement of SBM with BSF10% in the diet of laying hens improved feed efficiency attributed to a lower feed intake in comparison to laying hens fed the BSF5% or the control diets, while production performance, body weight, and egg quality were maintained and the colour of the egg yolk increased. Therefore, replacing SBM with up to 10% BSF in brown laying hens in aviary pens at the initiation of laying had no adverse effects on production performance, chemical and physical characteristics, and sensory attributes of eggs. Maintaining production and egg quality with a lower intake of nutrients requires further investigation.
Online Chat Counselling and Psychotherapy: A Scoping Review Protocol
Creators: name: Nogueira, Isabel Cunha
name: Henriques, Margarida Rangel
name: Mende, Fritz
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Counseling
subject: Telemedicine
subject: Clinical Psychology
subject: Psychology
subject: FOS: Psychology
subject: Health Information Technology
subject: Counseling Psychology
subject: Medicine and Health Sciences
subject: Internet Psychotherapy
subject: Online Therapy
subject: Online Counselling
subject: Chat-based
subject: Scoping Review Protocol
subject: Internet Counselling
subject: Chat Support
subject: Chat
subject: Synchronous Chat
subject: E-therapy

description: Online chat counselling and psychotherapy – synchronous text-based one-to-one engagement between a client and a counsellor or psychotherapist – is a fast-growing field, increasingly popular among clients and professionals, and widely available through virtual clinics and online mental healthcare services. Researchers in the field have pointed out that it is of utmost importance to firmly ground chat-based mental health interventions in empirical research, and over the last years, numerous studies and several systematic reviews have been carried out. Tentative support for the effectiveness of online interventions using synchronous chat has been reported, although, a solid evidence base is still lacking and many questions remain unanswered. A scoping review will be undertaken, targeting empirical studies on online chat counselling and psychotherapy – mapping and describing their focus and aims, methodology and research methods, summarising main findings, and identifying knowledge gaps in need of future research – to provide a comprehensive overview of the available research literature. The review will adhere to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-SCR) and the JBI Manual for Evidence Synthesis recommendations.
Additional file 5 of The effectiveness and acceptability of evidence synthesis summary formats for clinical guideline development groups: a mixed-methods systematic review
Creators: name: Sharp, Melissa K.
name: Baki, Dayang Anis Binti Awang
name: Quigley, Joan
name: Tyner, Barrie
name: Devane, Declan
name: Mahtani, Kamal R.
name: Smith, Susan M.
name: O’Neill, Michelle
name: Ryan, Máirín
name: Clyne, Barbara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5. Qualitative synthesis recommendations.
(CS2) Lucio's Phenomenon, Complication of Neglected Leprosy: A Case Series from Malaysia
Creators: name: His, Chang Wei
Publisher: name: Zenodo
Year: 2022

description: Introduction: Lucio’s phenomenon (LP), characterized by severe necrotizing cutaneous vasculitis, is a rare manifestation of lepromatous leprosy, due to high Mycobacterium leprae load. We describe 5 cases of LP who were admitted to the Dermatology Ward Hospital Kuala Lumpur between 2015 and 2021. Case series : Three Indonesians (2 males, 1 female) and two pregnant Malaysian females, with a mean age of 39.2 years presented with LP as the manifestation of leprosy. They had hypoesthetic skin patches for a mean of 16 months. All had grade 2 deformity, madarosis, thickened peripheral nerves, swelling and paresthesia of extremities, with extensive painful reticulated purpura and ulcerations of lower limbs. The mean bacteriological index and morphological index on slit skin smear were 3.9 and 1.2 respectively. Histopathology examinations of skin tissue revealed aggregates of foamy histiocytes in dermis and subcutaneous fat, thrombotic vasculopathy and presence of numerous bacilli on wade fite stain. They were prescribed daily rifampicin, clofazimine and dapsone for 3-4 weeks, followed by maintenance WHO Multibacillary regime together with prednisolone. The mean duration of in-patient stay was 33.6 days. The two pregnancies were complicated with anemia, oligohydramnios, and intrauterine growth restriction which led to preterm emergency caesarean section. Two patients developed dapsone induced anemia. Two suffered erythema nodosum leprosum concurrently. Three patients recovered with no relapse on surveillance, one loss to follow up, and one succumbed to sepsis. Conclusion : Management of LP is challenging. Intensive multi-drug therapy renders earlier elimination of live bacilli. In-patient supportive care and meticulous wound management are vital.
Additional file 1: Table S1. of Deep learning of mutation-gene-drug relations from the literature
Creators: name: Kyubum Lee
name: Byounggun Kim
name: Yonghwa Choi
name: Sunkyu Kim
name: Wonho Shin
name: Sunwon Lee
name: Sungjoon Park
name: Seongsoon Kim
name: Aik Tan
name: Jaewoo Kang
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Feature contribution analysis in our CNN model. Table S2. Results of simple co-occurrence-based method. Table S3. VarDrugPub and OncoKB comparison examples. Figure S1. Precision-Recall curves of our CNN classifier (Blue: Mutation-Gene, Red: Mutation-Drug). (DOCX 50 kb)
(CR3) A Case Report of Elemental Mercury Ingestion in A Psychiatric Patient
Creators: name: Roslan, Nurul Liana
Publisher: name: Zenodo
Year: 2022

description: Introduction: Pica, an eating habit disorder which substances with no significant nutritional value is consumed and it is related to psychiatric illness. We describe a case of intentional lightbulb ingestion which contained elemental mercury. Case Presentation : 46-year-old gentleman brought by police officers for attempted suicide, sustained soft tissue injury with a normal vitals, conscious level, and unremarkable findings of physical assessment. abdominal x-ray (AXR) showed multiple heterogenous opacities; ‘fireflies. Further history revealed that he has auditory and visual hallucinations for the past 3 years and worsened. He admitted that he enjoyed ingesting fluorescent light bulbs, which contain elemental mercury. Blood and urine samples were sent to detect mercury level, however, due to unavoidable glitch, no results able to be traced. Serial AXR was performed to monitor the passage of the radio-opaque substance which cleared on the fifth day. The patient was then discharged but defaulted his follow-up appointment. Conclusion : History of eating disorder in neuropsychiatric patients often abandoned. Classic triad of chronic mercury toxicity (tremor, gingivitis and erethism) was observed in our patient. Whole-blood mercury level of >5 micrograms/L or 24-hour urine mercury level of >20 micrograms/L only confirms the exposure but not its toxicity. Mercury appeared like ‘fireflies’ and ‘Christmas tree’ on abdominal and chest x-ray respectively. Chelating antidotes (dimercaprol and succimer) rarely required but prompt intervention needed in suspected perforation. For suspected mercury toxicity, thorough history; occupations, and dietary intake need to be explored. There is a role of observational medicine in alleged ingestion of mercury poisoning.
Proteome of Erythroxylum pungens (Erythroxylaceae): an endemic species of the semiarid Caatinga
Creators: name: Chacon, Daisy Sotero
name: da Silva, Ivanice Bezerra
name: Torres, Taffarel Melo
name: Pereira, Gabrielle Macedo
name: Moreira, Letícia Gondim Lambert
name: de Souza, Luiz Fernando Rodrigues
name: Reginaldo, Fernanda Priscila Santos
name: de Araújo Roque, Alan
name: Zuanazzi, José Angelo S.
name: Libonati, Renata
name: Rodrigues, Julia A.
name: Santos, Filippe L.M
name: Ricart, Carlos André O.
name: Castro, Mariana S.
name: Fontes, Wagner
name: de Sousa, Marcelo Valle
name: Fett-Neto, Arthur Germano
name: Giordani, Raquel Brandt
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Herein the descriptive label-free mass spectrometry (LC-MS/MS) proteome of Erythroxylum pungens (roots, barks, leaves) harvested from its natural habitat is described. Processes related to defense were most important in roots. Main protective proteins differed among organs, suggesting part-specific strategies of environmental adaptation.
Additional file 2: of The Mini-International Neuropsychiatric Interview is useful and well accepted as part of the clinical assessment for depression and anxiety in primary care: a mixed-methods study
Creators: name: Pettersson, Agneta
name: Modin, Sonja
name: WahlstrĂśm, Rolf
name: Hammarberg, Sandra Af Winklerfelt
name: Krakau, Ingvar
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Hematology

description: An example of the coding structure. (PDF 263Â kb)
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00738
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00738, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: Vom Bierbrauen zur Forschung im 21. Jahrhundert
Creators: name: Westermann, Benedikt
name: Klecker, Till
Publisher: name: University of Bayreuth
Year: 2022
Subjects: subject: 500
subject: 570

description: Baker’s yeast Saccharomyces cerevisiae has been used in the production of food and alcoholic beverages since ancient times. In the last century it emerged as a leading model organism for studying molecular processes in eukaryotic cells, and it still is a very powerful experimental system in 21st century biology. The remarkable features of this unicellular fungus made its astonishing journey from the brewery and bakery to the research laboratory possible.
Additional file 7 of The effectiveness and acceptability of evidence synthesis summary formats for clinical guideline development groups: a mixed-methods systematic review
Creators: name: Sharp, Melissa K.
name: Baki, Dayang Anis Binti Awang
name: Quigley, Joan
name: Tyner, Barrie
name: Devane, Declan
name: Mahtani, Kamal R.
name: Smith, Susan M.
name: O’Neill, Michelle
name: Ryan, Máirín
name: Clyne, Barbara
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 7. Qualitative synthesis recommendations (with at least 3 supporting studies or mixed methods support).
Additional file 1: Figure S1. of Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study
Creators: name: Shantakumar, Sumitra
name: Raoh-Fang Pwu
name: D’Silva, Liesel
name: Keele Wurst
name: Yao-Wen Kuo
name: Yen-Yun Yang
name: Juan, Yi-Chen
name: K. Arnold Chan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Patient flow diagram for the COPD cohort. Figure S2. Patient flow diagram for the asthma cohort. Figure S3. Patient flow diagram for the ACO cohort and groups with different ACO definitions. Table S1. Characteristics of the ACO cohort and groups with different ACO definitions at index date. Table S2. Respiratory-related medication use in the 12 months post-index date for the ACO cohort and groups with different ACO definitions. Table S3. All-cause medical utilisation in the asthma, COPD and ACO cohorts in the 12 months post-index date. Table S4. Respiratory-related medical utilisation in the 12 months post-index date for the ACO cohort and groups with different ACO definitions. (PDF 2324 kb)
(CR4) Bell's Palsy Post Administration of COVID-19 Inactivated Vaccine
Creators: name: Thivakar Sivalingam
Publisher: name: Zenodo
Year: 2022

description: Introduction: To report a case of Bell’s Palsy occurring post vaccination. Case Presentation: This is case report of a 23 years old Malay lady presented with left sided facial weakness over the past 2 weeks associated with occasional tearing over the left eye. Noted to have left sided facial weakness. No peripheral weakness. Patient was administered her first dose of COVID-19 vaccination 1 week prior to her presentation to the Ophthalmology clinic. Conclusion: Patients who have received inactivated COVID-19 vaccines may be at risk for developing Bell’s palsy
Conservation status of three endemic plants of the Selvagens Islands (Northern Atlantic Ocean): Argyranthemum thalassophilum, Asparagus nesiotes subsp. nesiotes and Euphorbia anachoreta
Creators: name: Carvalho, José Augusto
name: Vilatersana, Roser
name: López-Pujol, Jordi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Argyranthemum thalassophilum, Asparagus nesiotes subsp. nesiotes and Euphorbia anachoreta are three threatened taxa that are endemic to the Selvagens Islands, a very isolated archipelago of small islands in the Atlantic Ocean. As a part of a conservation project for the three taxa, we conducted fieldwork that included detailed censuses and identification of threatening factors, which ultimately allowed the assessment of their IUCN Red List status. The three species should be categorized as Endangered under the criterion D, as for all the cases there are fewer than 250 mature individuals (79, 119, and 58 for Argyranthemum thalassophilum, Asparagus nesiotes subsp. nesiotes and Euphorbia anachoreta, respectively). In spite of the fact that A. thalassophilum does not show the lowest census size, this taxon should be regarded as the most threatened because it is the only one showing no regeneration (i.e. a total lack of seedings and/or juveniles).
Additional file 4: Table S1. of Cerebral metabolic effects of strict versus conventional glycaemic targets following severe traumatic brain injury
Creators: name: Plummer, Mark
name: Notkina, Natalia
name: Timofeev, Ivan
name: Hutchinson, Peter
name: Finnis, Mark
name: Gupta, Arun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: Recorded variables by treatment phase. (DOCX 24 kb)
ТИПОЛОГИЯ КУЛЬТОВЫХ СООРУЖЕНИЙ КИТАЙСКО-ВОСТОЧНОЙ ЖЕЛЕЗНОЙ ДОРОГИ НАЧАЛА ХХ ВЕКА
Creators: name: Михайленко, Татьяна
Publisher: name: ООО Цифра
Year: 2024
Subjects: Trans-Siberian Railway
China Eastern Railway
church-school
orthodox church
typical construction
Транссибирская магистраль
Китайско-Восточная железная дорога
церковь-школа
православный храм
типовое строительство

description: Современное строительство и архитектура, Выпуск 3 (46) 2024
MOESM1 of Association between basilar artery configuration and Vessel Wall features: a prospective high-resolution magnetic resonance imaging study
Creators: name: Xu, Ziqi
name: Li, Mingyao
name: Hou, Zhikai
name: Lyu, Jinhao
name: Zhang, Na
name: Lou, Xin
name: Miao, Zhongrong
name: Ma, Ning
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Tables S1. Parameters of multiple sequences on GE and Siemens MR scanners.