cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
AN INTEGRATIVE APPROACH TO IDENTIFY BINDING PARTNERS OF MYC USING (EPI)GENOMICS DATA IN THE 3T9MYCER, EU-MYC AND TET-MYC SYSTEMS
Creators: name: BORA, PRANAMI
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: The c-MYC oncogene encodes the transcription factor Myc, which regulates a large number of biological processes and is overexpressed in a large number of cancers. When overexpressed, Myc binds to almost all open promoters but only regulates specific subsets of genes. We investigated this issue in three systems where Myc is overexpressed: 3T9MycER fibroblasts, E�-myc B cells and tet-MYC liver cells, through an approach integrating different types of next generation sequencing data, such as DNase-seq footprinting, ChIP-seq and RNA-seq, with motif analysis and machine learning methods (random forest). In particular, the DNase-seq technique can detect genome-wide open chromatin regions (DNase hypersensitive sites or DHSs) and sites where a transcription factor (TF) is bound (footprints). In order to analyse the DNase-seq footprinting data in our systems, we developed a novel pipeline that carries out a step-by-step analysis of the raw DNase-seq data, and outputs DHS and TF footprints. To select the best footprint caller for the pipeline we carried out a benchmarking study comparing two footprint calling algorithms DNaseR and Wellington on ENCODE data. The Wellington algorithm, scored consistently best both in terms of specificity and sensitivity and therefore it was chosen for our pipeline. We overlapped genome wide the footprints identified by the pipeline with matches of a PWM library, obtaining a list of footprinted PWMs. Then, we used this list as a series of features to carry out pairwise classifications of the upregulated, downregulated and not-deregulated subsets of genes in the three systems. A PWM that classifies the data with a large enough Area Under the Curve (AUC) pointed to a TF possibly selectively binding with Myc in a subset of genes only. We first applied a single feature classifier assessing the performance of each of the PWMs one by one, and we found that single PWMs only provided a limited classification of the gene subsets. We then turned to a random forest classifier that considers combinations of all the features. This strategy provided a good separation of the data sets (AUC>0.7) and identified some candidates, such as Nrf1/Nrf2 (E�-myc T up), Tead factors (E�-myc T and tet-MYC up), E2f4 (E�-myc T up) and E2f1(E�-myc T and tet-MYC up), that could potentially act with Myc in regulating specific subsets of genes.
title: Automatically Generating Functional Tests from Specifications - A Knowledge Based Constraint Logical Programming Approach
Creators: name: Chen, Ji
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1989

description: Recent experimental results indicate that functional testing is one of the most effective methods in detecting certain classes of faults. Very little work has been done in automating functional testing. This thesis research develops a method, called hierarchical partition, for automating functional testing. The key to our approach is the utilization of a pre-existing knowledge base about the domain of discourse. Several approaches to knowledge organiza­tion are discussed along with the resulting effects on the quantity and quality of functional tests produced. This research is an application and development of Generic Constraint Logic Programming and the Knowledge Driven Iterative Reasoning Architecture. The approach was applied to a small but significant and extensively studied software application known as the Launch Intercept Condition (LIC) problem. Preliminary results indicate that the application of the method described in this research could have been used to eliminate a significant class of logic errors generated during a previous study of LIC problem. Although results are not complete, we feel they demonstrate the effectiveness of the hierarchical partition method and constraint logic programming in the automation of functional testing.
FOSSR First Policy-maker session. Data Driven policy learning: the Role of FOSSR
Creators: name: REALE, EMANUELA
name: CERULLI, GIOVANNI
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Research infrastructures
subject: Data-driven
subject: Policy learning
subject: Open Cloud
subject: Policy design
subject: Social sciences
subject: FOS: Social sciences

description: This folders contains the presentations discussed during the FOSSR First policy-maker session, on the potential and limitations of data-driven policy learning. In particular, the development of a policy learning tool useful for guiding policy in different sectors has been discussed. It is an innovative system that harnesses the power of data and predictive analytics to improve policy design in different socio-economic domains.
Introduction by Emanuela Reale
Presentation by Giovanni Cerulli
Discussion with Andrea Giovanni Nuzzolese and Raffaello Bronzini
 
Session recording link: https://www.youtube.com/watch?v=BhwHJLbCLr0
Distortion-Aware Concurrent Multipath Transfer for Mobile Video Streaming in Heterogeneous Wireless Networks
Creators: name: Wu, Jiyan
name: Cheng, Bo
name: Yuen, Chau
name: Shang, Yanlei
name: Chen, Junliang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The massive proliferation of wireless infrastructures with complementary characteristics prompts the bandwidth aggregation for Concurrent Multipath Transfer (CMT) over heterogeneous access networks. Stream Control Transmission Protocol (SCTP) is the standard transport-layer solution to enable CMT in multihomed communication environments. However, delivering high-quality streaming video with the existing CMT solutions still remains problematic due to the stringent QoS (Quality of Service) requirements and path asymmetry in heterogeneous wireless networks. In this paper, we advance the state of the art by introducing video distortion into the decision process of multipath data transfer. The proposed Distortion-Aware Concurrent Multipath Transfer (CMT-DA) solution includes three phases: 1) per-path status estimation and congestion control; 2) quality-optimal video flow rate allocation; 3) delay and loss controlled data retransmission. The term `flow rate allocation' indicates dynamically picking appropriate access networks and assigning the transmission rates. We analytically formulate the data distribution over multiple communication paths to minimize the end-to-end video distortion and derive the solution based on the utility maximization theory. The performance of the proposed CMT-DA is evaluated through extensive semi-physical emulations in Exata involving H.264 video streaming. Experimental results show that CMT-DA outperforms the reference schemes in terms of video PSNR (Peak Signal-to-Noise Ratio), goodput, and inter-packet delay.
description: This paper has already accepted for publication in IEEE Transactions on Mobile Computing on Jun, 23rd, 2014
SIMBOLI E DIRITTI - UNO STUDIO SOCIOLOGICO-GIURIDICO SUL BURQA
Creators: name: FASSINI, IRENE
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: European politics, media and public opinion in the last decade has given prominence to the burqa as an icon of fundamentalist and almost terrorist Islam. This harsh debate has turned the typical garment of a religious and cultural tradition into a national security threat and a symbol of oppression against women. Thereby the opinion is that women are forced to wear the burqa as a duty sprung from family context or because they are considered "victims of their own culture", considering it a culture that promotes gender inequality and infringes female dignity and rights. The debate led to promulgate various measures to ban the burqa. France, Belgium, the Netherlands, Canton Ticino and Bulgaria have issued national laws, whereas other European are debating bills before Parliament. The reasons put forward by proponents of a ban on the burqa focus particularly on national security and the protection of women's rights. The analysis of these reasons allows the examination of their effectiveness relating to free will. In this context, it is important to evaluate whether the ban has enough social usefulness to permit a limitation of personal liberty (as the freedom of expression and the freedom of worship, even through the display of symbols). The examination of the Italian social, political and legal system, which has fueled the debate and the bills on the subject, leads to decrease the problematic nature of the burqa. It must be distinguished between what the symbol means and which kind of threat it really is. Meanwhile the origin of the burqa is deepened through archaeological, historical and literary documents dating back to pre-Islamic era to understand whether the symbol has much religious or cultural signi?cance. The outcome of this analysis shows that often the thoughts of the women who wear the burqa (0.5% of the Muslim population in Europe) are not even considered. For this reason, in the fourth chapter we try to give voice to the persons concerned, such as Muslim women who wear the full veil or those who simply wear the hijab through a qualitative empirical study conducted on a sample of 30 Muslim women, 8 of whose wear the burqa. Respondents perceive the ban as an interference by the State which claims the right to interpret the meaning of the practice of wearing the burqa and to standardize its display, unlike the same States do with customs of other denominations. They also emphasize the risk that banning the burqa could lead to counterproductive consequences compared with its original purpose. In addition, women report feeling free to decide to wear the burqa and are generally available to become identi?able. Therefore the points put forward relating to the needs of protection and emancipation of women and those of public security lose value which are the main arguments that are put forward in support of a general ban on the burqa.
An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.
Creators: name: Vivian, J. L.
name: Yee, D.
name: Magnuson, T.
name: Chen, Y.
name: Schneider, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Using selectable genes as proof of principle, a new high-throughput genotype-based mutation screen in mouse embryonic stem (ES) cells was developed [Chen et al. (2002) Nat. Genet. 24, 314–317]. If expanded to nonselectable genes, this approach would allow one to proceed quickly from sequence to whole-animal phenotypes. Here data are presented showing that a screen of a cryopreserved library of clonal, germ line competent, N-ethyl-N-nitrosurea (ENU) mutagenized ES cells can identify a large series of allelic mutations in Smad2 and Smad4, two nonselectable genes of the transforming growth factor β superfamily of signaling molecules. Whole animal phenotypic analyses of some of these alleles provided evidence for novel developmental processes mediated by these components of transforming growth factor β signaling, demonstrating the utility of non-null alleles created by chemical mutagens. The accurately assessed mutation load of the ES cell library indicates that it is a valuable resource for developing mouse lines for genetic and functional studies. This methodology can conceptually be applied for the generation of an allelic series of subtle mutations at any locus of interest in the mouse.
MPEC 2023-F71 : 2023 FV1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 FV1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Review on the mathematical modeling of cancer
Creators: name: Sbarra, Anthony
Publisher: name: No Publisher Supplied
Year: 2022

description: The goal of this project is to produce a meta-review analysis focused on the field of the mathematical modeling of cancer. Mathematical modeling of cancer is a large field that is made from different communities ranging from computational scientists, applied mathematicians, biophysicists, and more. Having a wide range of research is required as cancer is complex surrounding several different diseases with many mathematical methods proposed to approach these large areas to cover in cancer. This research was to conduct a survey of surveys from the analysis of many literature review papers from the communities for mathematical modeling of cancer. For the analysis an extensive list of supporting review literature was gathered to assist in looking for overlap and disjoint activities within the communities. While reading the literature can bring a depth of knowledge of the field as a whole, looking into aspects of the papers like keywords authorship, and citations can help to reveal more dynamics about the community. Using different graphs of networks from these things such as keywords can show how connected or disjoint aspects of the community have been over time. The research purpose helps to describe the different research communities for this broad and important topic while also looking at the scholarly production of the field, various approaches that are proposed, and how the community has evolved over time. The overall effect of the research can help bring communities together and ideas which can help advance the field for the mathematical modeling of cancer.
An Energetic Variational Approach for ion transport
Creators: name: Xu, Shixin
name: Sheng, Ping
name: Liu, Chun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The transport and distribution of charged particles are crucial in the study of many physical and biological problems. In this paper, we employ an Energy Variational Approach to derive the coupled Poisson-Nernst-Planck-Navier-Stokes system. All physics is included in the choices of corresponding energy law and kinematic transport of particles. The variational derivations give the coupled force balance equations in a unique and deterministic fashion. We also discuss the situations with different types of boundary conditions. Finally, we show that the Onsager's relation holds for the electrokinetics, near the initial time of a step function applied field.
Corporate climate liability: After Sharm El-Sheikh, Shell and Daimler judgement
Creators: name: Frenz, Walter
Publisher: name: RWTH Aachen University
Year: 2023

description: 12. Regional Meeting of the Society of Mining Professors, SOMP 2023, Nalaikh, Mongolia, 22 Jun 2023 - 23 Jun 2023; 10 Folien (2023).
35 years of public opinion surveys and European social citizenship: What can we conclude?
Creators: name: Eick, Gianna M.
name: Busemeyer, Marius R.
name: Burgoon, Brian
Publisher: name: Zenodo
Year: 2022
Subjects: welfare state
European Union
public opinion
social investment
convergence

description: What type of European social citizenship does the public across the European Union (EU) prefer on the national- and EU-levels? This paper empirically investigates the development of public opinion towards European social citizenship from 1985 to the present from a birds-eye perspective. The paper summarizes the large literature on welfare attitudes, adds new empirical evidence and points towards potential future research areas. To do that, we will review, consolidate and valorise existing large-scale quantitative research on the perceptions, attitudes and preferences of EU citizens concerning social rights.  It does so by drawing on and expanding a newly-compiled database, the Comparative Social Citizenship Dataset (CSCD), that brings together existing country-year macro data on policies, regulations, laws, social, economic and political conditions relevant to social rights, as well as public opinion data on these matters. Based on analyses of these CSCD measures, the paper focuses on painting a broad picture of a European social citizenship model from the perspective of public opinion, i.e. individual citizens’ perceptions and preferences.
Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity
Creators: name: Petes, T. D.
name: Hofmann, E. R.
name: Hengartner, M. O.
name: Greenwell, P.
name: Zhang, L.
name: Degtyareva, N. P.
name: Culotti, J. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Mismatch repair genes are important in maintaining the fidelity of DNA replication. To determine the function of the Caenorhabditis elegans homologue of the MSH2 mismatch repair gene (msh-2), we isolated a strain of C. elegans with an insertion of the transposable element Tc1 within msh-2. Early-passage msh-2 mutants were similar to wild-type worms with regard to lifespan and meiotic chromosome segregation but had slightly reduced fertility. The mutant worms had reduced DNA damage-induced germ-line apoptosis after genotoxic stress. The msh-2 mutants also had elevated levels of microsatellite instability and increased rates of reversion of the dominant unc-58(e665) mutation. In addition, serially passaged cultures of msh-2 worms died out much more quickly than those of wild-type worms. These results demonstrate that msh-2 function in C. elegans is important in regulating both short- and long-term genomic stability.
Deep Washington photometry of inconspicuous star cluster candidates in the Large Magellanic Cloud
Creators: name: Choudhury, Samyaday
name: Subramaniam, Annapurni
name: Piatti, Andrés E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present deep Washington photometry of 45 poorly populated star cluster candidates in the Large Magellanic Cloud (LMC). We have performed a systematic study to estimate the parameters of the cluster candidates by matching theoretical isochrones to the cleaned and de-reddened cluster color-magnitude diagrams (CMDs). We were able to estimate the basic parameters for 33 clusters, out of which, 23 are identified as single clusters and 10 are found to be members of double clusters. Other 12 cluster candidates have been classified as possible clusters/asterisms. About 50% of the true clusters are in the 100-300 Myr age range, while some are older or younger. We have discussed the distribution of age, location, reddening with respect to field as well as size of true clusters. The sizes and masses of the studied sample are found to be similar to that of open clusters in the Milky Way. Our study adds to the lower end of cluster mass distribution in the LMC, suggesting that the LMC apart from hosting rich clusters also has formed small, less massive open clusters in the 100-300 Myr age range.
description: 40 pages, 19 figures, 3 tables, Accepted for publication in the Astronomical Journal
Emergency Use of The Combination using OTC Quercetin and Bromelain with Zinc, Vitamin C and Vitamin D for the potential Symptom Reducer, Treatment of and Prevention of Coronavirus 2019 (COVID-19) SARS-CoV-2 when taken in conjunction
Creators: name: Orzechowski, Michelle
Publisher: name: figshare
Year: 2023
Subjects: Infectious diseases
Immunology not elsewhere classified

description: Emergency Use of The Combination using OTC Quercetin and Bromelain with Zinc, Vitamin C and Vitamin D for the potential Symptom Reducer, Treatment of and Prevention of Coronavirus 2019 (COVID-19) SARS-CoV-2 when taken in conjunction
Model Hamiltonian for topological Kondo insulator SmB6
Creators: name: Yu, Rui
name: Weng, HongMing
name: Hu, Xiao
name: Fang, Zhong
name: Dai, Xi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Starting from the kp method in combination with first-principles calculations, we systematically derive the effective Hamiltonians that capture the low energy band structures of recently discovered topological Kondo insulator SmB6. Using these effective Hamiltonians we can obtain both the energy dispersion and the spin texture of the topological surface states, which can be detected by further experiments.
description: 6 pages, 4 figures
Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups
Creators: name: Chamberlin, S. I.
name: Weeks, K. M.
name: Merino, E. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The functional groups found among the RNA bases and in the phosphoribose backbone represent a limited repertoire from which to construct a ribozyme active site. This work investigates the possibility that simple RNA phosphodiester and hydroxyl functional groups could catalyze amide bond synthesis. Reaction of amine groups with activated esters would be catalyzed by a group that stabilizes the partial positive charge on the amine nucleophile in the transition state. 2′-Amine substitutions adjacent to 3′-phosphodiester or 3′-hydroxyl groups react efficiently with activated esters to form 2′-amide and peptide products. In contrast, analogs in which the 3′-phosphodiester is replaced by an uncharged phosphotriester or is constrained in a distal conformation react at least 100-fold more slowly. Similarly, a nucleoside in which the 3′-hydroxyl group is constrained trans to the 2′-amine is also unreactive. Catalysis of synthetic reactions by RNA phosphodiester and ribose hydroxyl groups is likely to be even greater in the context of a preorganized and solvent-excluding catalytic center. One such group is the 2′-hydroxyl of the ribosome-bound P-site adenosine substrate, which is close to the amine nucleophile in the peptidyl synthesis reaction. Given ubiquitous 2′-OH groups in RNA, there exists a decisive advantage for RNA over DNA in catalyzing reactions of biological significance.
Gravitational waves from the collision of tidally disrupted stars with massive black holes
Creators: name: East, William E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We use simulations of hydrodynamics coupled with full general relativity to investigate the gravitational waves produced by a star colliding with a massive black hole when the star's tidal disruption radius lies far outside of the black hole horizon. We consider both main-sequence and white-dwarf compaction stars, and nonspinning black holes, as well as those with near-extremal spin. We study the regime in between where the star can be accurately modeled by a point particle, and where tidal effects completely suppress the gravitational wave signal. We find that nonnegligible gravitational waves can be produced even when the star is strongly affected by tidal forces, as well as when it collides with large angular momentum. We discuss the implications that these results have for the potential observation of gravitational waves from these sources with future detectors.
description: 10 pages, 13 figures; revised to match ApJ version
title: Emotionen und Emotionsregulation im Vorschulalter: Was zeigt sich im dyadischen Spiel?
Creators: name: Diebold, Tatiana
name: Burkhardt Bossi, Carine
name: Nischak, Pablo
name: Lorusso, Sonja
name: Perren, Sonja
Publisher: name: Publikationsserver der Pädagogischen Hochschule Thurgau
Year: 2023
Subjects: sozial-emotionale Entwicklung
Vorschulalter
Spiel
frühes Lernen
Soziales Lernen

description: Der Emotionsregulation wird eine hohe Bedeutung für die gesunde Entwicklung und für das erfolgreiche Lernen beigemessen. Ferner führen hohe soziale und emotionale Kompetenzen zu mehr Akzeptanz in einer Gruppe, was wiederum das Wohlbefinden positiv beeinflussen kann. Der Artikel gibt einen Einblick in die ersten Resultate des Projekts «EmU – Emotionen unter Kindern» des Schweizerischen Nationalfonds (SNF) und formuliert daraus Erkenntnisse für die Praxis.
description: Schweizerische Zeitschrift für Heilpädagogik, vol. 29, no. 9, p. 2
Mehrsprachige Auslegung zwischen EU-Verbraucherschutz und WTO-Recht: das Verhältnis von verschiedenen Sprachfassungen und dem Regelungszweck
Creators: name: Frenz, Walter
Publisher: name: RWTH Aachen University
Year: 2023

description: Veranstaltungen des ERL-Vereins und des Instituts für Völkerrecht und ausländisches öffentliches Recht der Universität zu Köln, Köln, Germany; 6 Folien (2023).
Altlastensanierung – Vor- und Nachsorge nach demKlimabeschluss des BVerfG
Creators: name: Frenz, Walter
Publisher: name: RWTH Aachen University
Year: 2023

description: AAV-Fachtagung „Aktuelle Rechtsfragen zum Altlasten- und Bodenschutzrecht“, Hattingen, Germany, 31 May 2023 - 31 May 2023; 14 Folien (2023).
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
Creators: name: Xu, W.
name: Marcu, M.
name: Yuan, X.
name: Patterson, C.
name: Mimnaugh, E.
name: Neckers, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Overexpression of the transmembrane receptor tyrosine kinase ErbB2 is common in multiple malignancies, including breast and ovarian cancer. ErbB2 is resistant to degradation mediated by c-Cbl, the E3 ubiquitin ligase responsible for ligand-induced ubiquitination of ErbB1 (epidermal growth factor receptor). Because of its resistance to degradation, ErbB2 is the preferred dimerization partner for other members of the ErbB family, and its overexpression in vivo is associated with poor prognosis. We now show that the chaperone-binding ubiquitin ligase CHIP efficiently ubiquitinates and down-regulates ErbB2. CHIP expression shortens the half-life of both nascent and mature ErbB2 protein. In vitro ubiquitination assay shows that CHIP serves as a ubiquitin ligase for ErbB2, and both exogenously expressed and endogenous CHIP coprecipitate with the kinase. Furthermore, CHIP association with ErbB2 requires a chaperone intermediate and is increased by the chaperone-binding drug geldanamycin, a potent stimulator of ErbB2 ubiquitination and degradation. These data describe a previously unrecognized pathway, amenable to pharmacologic manipulation, that mediates ErbB2 stability.
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
Creators: name: Ke, H.
name: Mondragon, A.
name: Zhao, Y.
name: Kim, H.-Y.
name: Liu, Y.
name: Huai, Q.
name: Liu, J. O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How the two structurally distinct immunophilin–drug complexes bind the same target has remained unknown. We report the crystal structure of calcineurin (CN) in complex with CyPA-CsA at 2.8-Å resolution. The CyPA-CsA complex binds to a composite surface formed by the catalytic and regulatory subunits of CN, where the complex of FK506 and its binding protein FKBP also binds. While the majority of the CN residues involved in the binding are common for both immunophilin-immunosuppressant complexes, a significant number of the residues are distinct. Unlike FKBP-FK506, CyPA-CsA interacts with Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN catalysis. The simultaneous interaction of CyPA with both the composite surface and the active site of CN suggests that the composite surface may serve as a substrate recognition site responsible for the narrow substrate specificity of CN. The comparison of CyPA-CsA-CN with FKBP-FK506-CN significantly contributes to understanding the molecular basis of regulation of CN activity by the immunophilin–immunosuppressant.
Stable knots in the trapped Bose-Einstein condensates
Creators: name: Liu, Yong-Kai
name: Feng, Shiping
name: Yang, Shi-Jie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The knot of spin texture is studied within the two-component Bose-Einstein condensates which are described by the nonlinear Gross-Pitaevskii equations. We start from the non-interacting equations including an axisymmetric harmonic trap to obtain an exact solution, which exhibits a non-trivial topological structure. The spin-texture is a knot with an integral Hopf invariant. The stability of the knot is verified by numerically evolving the nonlinear Gross-Pitaevskii equations along imaginary time.
description: 4 pages, 5 figures
Towards an integrated blood pressure self-monitoring solution for stroke/TIA in Ireland: a mixed methods feasibility study for the TASMIN5S IRL randomised controlled trial
Creators: name: Doogue, Roisin
name: HAYES, PETER
name: Hebert, R.
name: Sheikhi, A.
name: Rai, T
name: Morton, K
name: Roman, C.
name: Mcmanus, R J
name: GLYNN, LIAM
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background Optimising blood pressure (BP) control is one of the most important modifable risk factors in preventing subsequent stroke where the risk increases by one-third for every 10 mmHg rise in systolic BP. This study evaluated the feasibility and potential efectiveness of blood pressure self-monitoring with planned medication titration, to inform a defnitive trial of the intervention, in patients with a previous stroke or transient ischaemic attack (TIA). Methods Patients with a history of stroke/TIA and sub-optimal BP control were invited to take part in a mixed methods feasibility study for a randomised controlled trial. Those meeting the inclusion criteria with systolic BP >130 mmHg were randomised to a self-monitoring intervention group or usual care group. The intervention involved self-monitoring BP twice a day for 3 days within a 7-day period, every month, following text message reminders. Treatment escalation, based on a pre-agreed plan by the general practitioner (GP) and patient, was initiated according to the results of these readings. Semi-structured interviews were carried out with patients and clinicians and analysed thematically. Results Of those identifed, 47% (32/68) attended for assessment. Of those assessed, 15 were eligible for recruitment and were consented and randomised to the intervention or control group on a 2:1 basis. Of those randomised, 93% (14/15) completed the study and there were no adverse events. Systolic BP was lower in the intervention group at 3 months. Participants found the intervention acceptable and easy to use. GPs found it easy to incorporate into their practice activity without increasing workload. Conclusions TASMIN5S, an integrated blood pressure self-monitoring intervention in patients with a previous stroke/TIA, is feasible and safe to deliver in primary care. A pre-agreed three-step medication titration plan was easily implemented, increased patient involvement in their care, and had no adverse efects. This feasibility study provides important information to inform a defnitive trial to determine the potential efectiveness of the intervention in patients post-stroke or TIA.
Die Sicherung der Energieversorgung vor dem Hintergrund des Atom- und Kohleausstiegs
Creators: name: Frenz, Walter
Publisher: name: RWTH Aachen University
Year: 2023

description: Berliner Klimaschutztag 2023, Berlin, Germany, 24 Mar 2023 - 24 Mar 2023; 13 Folien (2023).
Diskussion: CO²-Preis als Klimaschutzinstrument für die Abfallwirtschaft?
Creators: name: Frenz, Walter
Publisher: name: RWTH Aachen University
Year: 2023

description: Bundeskongress der Abfallwirtschaft und Stadtsauberkeit, Berlin, Germany, 3 May 2023 - 4 May 2023; 4 Folien (2023).
An Analysis of Factors Affecting Job Satisfaction and Employment Determination of College Graduates in Agriculture, forestry and fishing Industry
Creators: name: Kang, Hyejung
name: Kang, Hyejung
Publisher: name: Unknown
Year: 2019
Subjects: subject: Resource /Energy Economics and Policy
subject: Young College graduate
subject: Agriculture, Forestry & Fisheries jobs
subject: Job satisfaction

description: This study analyzes the determinants of employment in agriculture, forestry, and fisheries, and the degree of satisfaction with jobs in the industries by using data from the Graduates Occupational Mobility Survey. The Logit model is used to analyze factors affecting young college graduates' choice of employment in agriculture, forestry, and fisheries. The Ordered Probit model is used to analyze factors influencing overall job satisfaction of agriculture, forestry, and fisheries. Results indicate that graduates from agricultural colleges have a higher probability of employment in agriculture, forestry, and fisheries. When their spouses' vocation is related to agriculture, forestry, and fisheries, they are more likely to engage in the industries. The higher the likelihood of their aptitude and interest are or the brighter the future prospects for agriculture are, the higher the probability of employment in agriculture forestry, and fisheries is. The higher the satisfaction of wage or income, job stability, and working hours, the larger overall job satisfaction is. In addition, the higher the satisfaction of job-related education or training is, the higher overall job satisfaction is. Consequently, higher education institutions need to provide on-site education and training related to agriculture, forestry, and fisheries.
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
Creators: name: Church, F. C.
name: Carrell, R. W.
name: Baglin, T. P.
name: Huntington, J. A.
name: Esmon, C. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique β-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been controversy as to the role of conformational change in their mechanism. It now is clear that protease inhibition depends entirely on rapid serpin β-sheet expansion after proteolytic attack. The regulatory advantage afforded by the conformational mobility of serpins is demonstrated here by the structures of native and S195A thrombin-complexed heparin cofactor II (HCII). HCII inhibits thrombin, the final protease of the coagulation cascade, in a glycosaminoglycan-dependent manner that involves the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. The native structure of HCII resembles that of native antithrombin and suggests an alternative mechanism of allosteric activation, whereas the structure of the S195A thrombin–HCII complex defines the molecular basis of allostery. Together, these structures reveal a multistep allosteric mechanism that relies on sequential contraction and expansion of the central β-sheet of HCII.
On the second main theorem of Cartan
Creators: name: Eremenko, Alexandre
Publisher: name: arXiv
Year: 2014
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30D35, 32A22

description: The possibility of reversion of the inequality in the Second Main Theorem of Cartan in the theory of holomorphic curves in projective space is discussed. A new version of this theorem is proved that becomes an asymptotic equality for a class of holomorphic curves defined by solutions of linear differential equations.
description: 18 pages. A mistake in the proof of Theorem 2 of the first version is corrected
Expanding protein universe and its origin from the biological Big Bang
Creators: name: Shakhnovich, B.
name: Dokholyan, N. V.
name: Shakhnovich, E. I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.
String tension from smearing and Wilson flow methods
Creators: name: González-Arroyo, Antonio
name: Okawa, Masanori
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, we proposed a new method to extract the string tension from 4-dimensionally smeared Wilson loops. In this talk, we first show that the results obtained using this smearing method are identical to those obtained by Wilson flow, once the time step is sufficiently small. We then demonstrate the practical advantage of our method by applying it to the calculation of string tension in SU(3) Yang-Mills theory.
description: 7 pages, 10 figures, Contribution to the 32nd International Symposium on Lattice Field Theory (Lattice 2014), 23-28 June 2014, Columbia University, New York, NY, USA
Low-temperature heat transport of Nd_{2-x}Ce_{x}CuO_{4} single crystals
Creators: name: Zhao, X.
name: Zhao, Z. Y.
name: Ni, B.
name: Wu, J. C.
name: Zhang, F. B.
name: Song, J. D.
name: Li, S. J.
name: Sun, X. F.
name: Li, X. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report a study of the Ce doping effect on the thermal conductivity (κ) of Nd_{2-x}Ce_{x}CuO_{4} (NCCO) at low temperatures down to 0.3 K and in magnetic fields up to 14 T. It is found that with Ce doping, the electronic thermal conductivity increases; at the same time, the a-axis field induced changes in κ(H), associated with the spin flop and spin polarization of Nd^{3+} sublattice, and the spin flop of Cu^{2+} sublattice, gradually disappear. These are clearly due to the electron doping and the destruction of the antiferromagnetic orders. In the superconducting NCCO with x = 0.14 and 0.18, although the electronic thermal conductivity shows sizable field dependencies with H // c, the paramagnetic scattering of phonons is still playing the dominant role in the heat transport, which is different from many other cuprates. In the lightly doped samples (x = 0.03 and 0.06), the low-T κ(H) isotherms with H // c show a step-like anomaly and is likely related to the spin/charge stripes.
description: 10 pages, 7 figures, accepted for publication in Phys. Rev. B
FlgM gains structure in living cells
Creators: name: Pielak, G. J.
name: Dedmon, M. M.
name: Patel, C. N.
name: Young, G. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Intrinsically disordered proteins such as FlgM play important roles in biology, but little is known about their structure in cells. We use NMR to show that FlgM gains structure inside living Escherichia coli cells and under physiologically relevant conditions in vitro, i.e., in solutions containing high concentrations (≥400 g/liter) of glucose, BSA, or ovalbumin. Structure formation represents solute-induced changes in the equilibrium between the structured and disordered forms of FlgM. The results provide insight into how the environment of intrinsically disordered proteins could dictate their structure and, in turn, emphasize the relevance of studying proteins in living cells and in vitro under physiologically realistic conditions.
On Perturbation theory improved by Strong coupling expansion
Creators: name: Honda, Masazumi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Lattice (hep-lat)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In theoretical physics, we sometimes have two perturbative expansions of physical quantity around different two points in parameter space. In terms of the two perturbative expansions, we introduce a new type of smooth interpolating function consistent with the both expansions, which includes the standard Padé approximant and fractional power of polynomial method constructed by Sen as special cases. We point out that we can construct enormous number of such interpolating functions in principle while the "best" approximation for the exact answer of the physical quantity should be unique among the interpolating functions. We propose a criterion to determine the "best" interpolating function, which is applicable except some situations even if we do not know the exact answer. It turns out that our criterion works for various examples including specific heat in two-dimensional Ising model, average plaquette in four-dimensional SU(3) pure Yang-Mills theory on lattice and free energy in c=1 string theory at self-dual radius. We also mention possible applications of the interpolating functions to system with phase transition.
description: 31+11 pages, 15 figures, 9 tables, 1 Mathematica file; v3: minor corrections
Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors
Creators: name: Botstein, D.
name: Lonning, P. E.
name: Tibshirani, R.
name: Borresen-Dale, A.-L.
name: Perou, C. M.
name: Brown, P. O.
name: Pollack, J. R.
name: Jeffrey, S. S.
name: Rees, C. A.
name: Sorlie, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Genomic DNA copy number alterations are key genetic events in the development and progression of human cancers. Here we report a genome-wide microarray comparative genomic hybridization (array CGH) analysis of DNA copy number variation in a series of primary human breast tumors. We have profiled DNA copy number alteration across 6,691 mapped human genes, in 44 predominantly advanced, primary breast tumors and 10 breast cancer cell lines. While the overall patterns of DNA amplification and deletion corroborate previous cytogenetic studies, the high-resolution (gene-by-gene) mapping of amplicon boundaries and the quantitative analysis of amplicon shape provide significant improvement in the localization of candidate oncogenes. Parallel microarray measurements of mRNA levels reveal the remarkable degree to which variation in gene copy number contributes to variation in gene expression in tumor cells. Specifically, we find that 62% of highly amplified genes show moderately or highly elevated expression, that DNA copy number influences gene expression across a wide range of DNA copy number alterations (deletion, low-, mid- and high-level amplification), that on average, a 2-fold change in DNA copy number is associated with a corresponding 1.5-fold change in mRNA levels, and that overall, at least 12% of all the variation in gene expression among the breast tumors is directly attributable to underlying variation in gene copy number. These findings provide evidence that widespread DNA copy number alteration can lead directly to global deregulation of gene expression, which may contribute to the development or progression of cancer.
Dispersion engineered silicon nitride waveguides by geometrical and refractive-index optimization
Creators: name: Boggio, J. M. Chavez
name: Bodenmueller, D.
name: Fremberg, T.
name: Haynes, R.
name: Roth, M. M.
name: Eisermann, R.
name: Lisker, M.
name: Zimmermann, L.
name: Boehm, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Dispersion engineering in silicon nitride (SiX NY ) waveguides is investigated through the optimization of the waveguide transversal dimensions and refractive indices in a multi-cladding arrangement. Ultra-flat dispersion of -84.0 +/- 0.5 ps/nm/km between 1700 and 2440 nm and 1.5 +/- 3 ps/nm/km between 1670 and 2500 nm is numerically demonstrated. It is shown that typical refractive index fluctuations as well as dimension fluctuations during the fabrication of the SiX NY waveguides are a limitation for obtaining ultra-flat dispersion profiles. Single- and multi-cladding waveguides are fabricated and their dispersion profiles measured (over nearly 1000 nm) using a low-coherence frequency domain interferometric technique. By appropriate thickness optimization, the zero-dispersion wavelength is tuned over a large spectral range in both single-cladding waveguides and multi-cladding waveguides with small refractive index contrast (3 %). A flat dispersion profile with 3.2 ps/nm/km variation over 500 nm is obtained in a multi-cladding waveguide fabricated with a refractive index contrast of 37 %. Finally, we generate a nearly three-octave supercontinuum in this dispersion flattened multi-cladding SiX NY waveguide.
Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster
Creators: name: Gilbert, L. I.
name: Parvy, J.-P.
name: Jarcho, M.
name: Petryk, A.
name: O'Connor, M. B.
name: Marques, G.
name: Warren, J. T.
name: Dauphin-Villemant, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Five different enzymatic activities, catalyzed by both microsomal and mitochondrial cytochrome P450 monooxygenases (CYPs), are strongly implicated in the biosynthesis of ecdysone (E) from cholesterol. However, none of these enzymes have been characterized completely. The present data show that the wild-type genes of two members of the Halloween family of embryonic lethals, disembodied (dib) and shadow (sad), code for mitochondrial cytochromes P450 that mediate the last two hydroxylation reactions in the ecdysteroidogenic pathway in Drosophila, namely the C22- and C2-hydroxylases. When sad (CYP315A1) is transfected into Drosophila S2 cells, the cells metabolize 2-deoxyecdysone (2dE) to E and the [3H]ketotriol (2,22-dideoxyecdysone) to 22-deoxyecdysone. In contrast, dib (CYP302A1) is responsible for the conversion of the [3H]ketotriol to [3H]2dE. When cells are transfected with both dib and sad, they metabolize the [3H]ketotriol to [3H]E in high yield. The expression of sad and dib is concentrated within the individual segments of the developing epidermis when there is a surge of ecdysteroid midway through embryogenesis. This result occurs before the ring gland has developed and suggests that the embryonic epidermis is a site of ecdysteroid biosynthesis. This pattern then diminishes, and, during late embryogenesis, expression of both genes is concentrated in the prothoracic gland cells of the developing ring gland. Expression of dib and sad continues to be localized in this endocrine compartment during larval development, being maximal in both the late second and third instar larvae, about the time of the premolt peaks in the ecdysteroid titer.