cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.
Creators: name: Palta, Priya
name: Klein, Ronald
name: Klein, Barbara E
name: Meyer, Michelle L
name: Tanaka, Hirofumi
name: Wong, Tien Y
name: Nambi, Vijay
name: Heiss, Gerardo
name: Sharrett, A Richey
Publisher: name: Wolters Kluwer
Year: 2020

description: BACKGROUND: The retinal microvasculature provides a window to the cerebral vasculature and enables examination of changes in retinal caliber that may mimic those occurring in cerebrovascular disease. The association of central arterial stiffness and retinal vessel caliber in a population sample is not fully understood. METHODS: In 1706 older adults (mean age 76.3, 58.1% women) from the population-based Atherosclerosis Risk in Communities Study, we examined the cross-sectional association of central arterial stiffness [carotid-femoral pulse wave velocity (cfPWV)] with retinal vessel calibers [central retinal arteriolar equivalent (CRAE) and central retinal vein equivalent (CRVE)]. We estimated the association of cfPWV with CRAE narrowing (<25th percentile) and CRVE widening (>75th percentile) after adjustment for age, sex, race-field center, BMI, smoking, and type 2 diabetes. We tested for effect modification by sex, hypertension, and type 2 diabetes. RESULTS: Carotid-femoral PWV (m/s) was not associated with the odds of CRAE narrowing [odds ratio (OR): 0.99; 95% CI: 0.95-1.03]. The association of cfPWV with CRVE widening was stronger in those without hypertension (OR: 1.10; 95% CI: 1.01-1.20) versus those with hypertension (OR: 1.01 95% CI: 0.96-1.05) and slightly stronger in those with type 2 diabetes (OR: 1.07; 95% CI: 1.00-1.14) versus without type 2 diabetes (OR: 1.01; 95% CI: 0.96-1.06). CONCLUSIONS: In older adults, cfPWV was associated with wider retinal venular caliber, particularly in individuals without hypertension. Central arterial stiffening may be associated with cerebral microvascular changes, as exhibited in its retinal vasculature component.
Community Health Worker Training Curricula and Intervention Outcomes in African American and Latinx Communities: A Systematic Review
Creators: name: Corbie-Smith, Giselle
name: Adams, Leslie B.
name: Dunlap, Phenesse
name: Cene, Crystal W.
name: Richmond, Jennifer
name: Urrutia, Rachel
name: Watson, Sable N.
name: Ataga, Onome
Publisher: name: SAGE Publications
Year: 2020

description: In recent years, community health workers (CHWs) have emerged as key stakeholders in implementing community-based public health interventions in racially diverse contexts. Yet little is known about the extent to which CHW training curriculums influence intervention effectiveness in marginalized racial and ethnic minority communities. This review summarizes evidence on the relationship between CHW training curricula and intervention outcomes conducted among African American and Latinx populations. We conducted a literature search of intervention studies that focused on CHW public health interventions in African American and Latinx populations using PubMed, PsycINFO, ERIC, CINAHL, EMBASE, and Web of Science databases. Included studies were quantitative, qualitative, and mixed methods studies employed to conduct outcome (e.g., blood pressure and HbA1c) and process evaluations (e.g., knowledge and self-efficacy) of CHW-led interventions. Out of 3,295 articles from the database search, 36 articles met our inclusion criteria. Overall, the strength of evidence linking specific CHW training curricula components to primary intervention health outcomes was weak, and no studies directly linked outcomes to specific characteristics of CHW training. Studies that described training related to didactic sessions or classified as high intensity reported higher percentages of positive outcomes compared to other CHW training features. These findings suggest that CHW training may positively influence intervention effectiveness but additional research using more robust methodological approaches is needed to clarify these relationships.
Comparison of different methods of initiating lung inflammation and the sex-specific effects on inflammatory parameters
Creators: name: Tune, Miriya K
name: McCullough, Morgan J
name: Bose, Pria G
name: Mock, Jason R
name: Doerschuk, Claire M
Publisher: name: American Physiological Society
Year: 2023

description: Sex as a biological variable is an essential element of preclinical research. Sex-specific differences in lung volume, alveolar number, body weight, and the relationship between lung and body weight result in important questions about generating equivalent injuries in males and females so that comparisons in their responses can be assessed. Few studies compare stimulus dosing methods for murine lung models investigating immune responses. To examine sex-specific effects, we explored several dosing techniques for three stimuli, LPS, Streptococcus pneumoniae, and influenza A, on survival, injury parameters in bronchoalveolar lavage (BAL), and immune cell numbers in single-cell lung suspensions after injury. These data demonstrate that body weight-based dosing produced fewer differences between sexes when compared with injury initiated with inocula containing the same number of organisms. Comparison of the lung and body weights showed that females had a greater lung-to-body weight ratio than males. However, in LPS-induced injury, adjusting the dose for sex differences in this ratio in addition to body weight provided no new information about sex differences compared with dosing by body weight alone, most likely due to the variability in measures of the immune response. Studies evaluating BAL volumes revealed that smaller but more lavages resulted in greater returns and lower protein concentrations, particularly in the smaller female lungs. Thus, designing dosing and measurement methods that generate equivalent injuries facilitates comparison of immune responses between sexes. Continued development of methods for both induction and evaluation of injury will likely facilitate identification of sex differences in immune responses.
Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis
Creators: name: Brookhart, M Alan
name: Flythe, Jennifer E
name: Assimon, Magdalene M
Publisher: name: Wolters Kluwer
Year: 2019

description: BACKGROUND: Individuals receiving maintenance hemodialysis may be particularly susceptible to the lethal cardiac consequences of drug-induced QT prolongation because they have a substantial cardiovascular disease burden and high level of polypharmacy, as well as recurrent exposure to electrolyte shifts during dialysis. Electrophysiologic data indicate that among the selective serotonin reuptake inhibitors (SSRIs), citalopram and escitalopram prolong the QT interval to the greatest extent. However, the relative cardiac safety of SSRIs in the hemodialysis population is unknown. METHODS: In this retrospective cohort study, we used data from a cohort of Medicare beneficiaries receiving hemodialysis included in the US Renal Data System registry (2007-2014). We used a new-user design to compare the 1-year risk of sudden cardiac death among hemodialysis patients initiating SSRIs with a higher potential for prolonging the QT interval (citalopram, escitalopram) versus the risk among those initiating SSRIs with lower QT-prolonging potential (fluoxetine, fluvoxamine, paroxetine, sertraline). We estimated adjusted hazard ratios using inverse probability of treatment weighted survival models. Nonsudden cardiac death was treated as a competing event. RESULTS: The study included 30,932 (47.1%) hemodialysis patients who initiated SSRIs with higher QT-prolonging potential and 34,722 (52.9%) who initiated SSRIs with lower QT-prolonging potential. Initiation of an SSRI with higher versus lower QT-prolonging potential was associated with higher risk of sudden cardiac death (adjusted hazard ratio, 1.18; 95% confidence interval, 1.05 to 1.31). This association was more pronounced among elderly individuals, females, patients with conduction disorders, and those treated with other non-SSRI QT-prolonging medications. CONCLUSIONS: The heterogeneous QT-prolonging potential of SSRIs may differentially affect cardiac outcomes in the hemodialysis population.
Detection Of Mev Supernova Neutrinos With The Km3Net Neutrino Telescope
Creators: name: LINCETTO, Massimiliano
Publisher: name: Zenodo
Year: 2018

description: Core Collapse Supernovae (CCSN) are explosive phenomena that may occur at the end of the life of massive stars, releasing over 99% of the energy through emission of MeV neutrinos. Neutrinos are believed to play an important role in the not yet fully understood explosion mechanism. Only 24 SN neutrinos have been detected from the SN1987A event.

For a galactic CCSN, the KM3NeT ORCA and ARCA detectors in the Mediterranean will observe a significant number of neutrinos via Cherenkov light, mostly from inverse beta decay interactions in a large seawater volume. Selection of coincidences between the 31 photomultipliers of KM3NeT optical modules allows to separate the signal from the optical background sources.

The KM3NeT sensitivity for the detection of a galactic CCSN and the potential for the study of the burst time profile have been estimated from MC simulations. Specific criteria are proposed for the online triggering and the participation in the SNEWS global alert network.
Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases
Creators: name: O'Banion, Colin P
name: Lawrence, David S
name: Haar, Lauren
name: Vickerman, Brianna M
Publisher: name: Elsevier
Year: 2019

description: Because small-molecule activators of adenylyl cyclases (AC) affect ACs cell-wide, it is challenging to explore the signaling consequences of AC activity emanating from specific intracellular compartments. We explored this issue using a series of engineered, optogenetic, spatially restricted, photoactivable adenylyl cyclases (PACs) positioned at the plasma membrane (PM), the outer mitochondrial membrane (OMM), and the nucleus (Nu). The biochemical consequences of brief photostimulation of PAC is primarily limited to the intracellular site occupied by the PAC. By contrast, sustained photostimulation results in distal cAMP signaling. Prolonged cAMP generation at the OMM profoundly stimulates nuclear protein kinase (PKA) activity. We have found that phosphodiesterases 3 (OMM and PM) and 4 (PM) modulate proximal (local) cAMP-triggered activity, whereas phosphodiesterase 4 regulates distal cAMP activity as well as the migration of PKA's catalytic subunit into the nucleus.
COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database
Creators: name: Korn, Daniel
name: Chirkova, Rada
name: Muratov, Eugene
name: Owen, Phillips
name: Vaidya, Gaurav
name: Tropsha, Alexander
name: Bizon, Chris
name: Kebede, Yaphet
name: Wang, Patrick
name: Li, Michael
name: Bobrowski, Tesia
Publisher: name: Oxford University Press (OUP)
Year: 2020

description: SUMMARY: In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respective confirmatory pathways of drug action. AVAILABILITY AND IMPLEMENTATION: COVID-KOP is freely accessible at https://covidkop.renci.org/. For code and instructions for the original ROBOKOP, see: https://github.com/NCATS-Gamma/robokop.
COVID-19: Clean up on IL-6
Creators: name: Murray, Brian P.
name: Hagan, Robert S.
name: Mock, Jason R.
name: Hedrick, Tanner L.
Publisher: name: American Thoracic Society
Year: 2020

description: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the latest threat to global health security, and the pressure to identify effective therapeutics during this pandemic is immense. This stress has led to the use of unproven therapies with greater than minimal risk. One example is the use of IL-6 receptor antagonists. After an early report of a “cytokine storm” in patients with coronavirus disease (COVID-19), there is increased interest in anti–IL-6 therapy as a treatment option, with ill-defined criteria for use (1).
Cultivating a Research-Ready Dialysis Community
Creators: name: Mitchell, Denise
name: Ordish, Antoinette
name: Hilliard, Tandrea
name: Lee, Shoou-Yih Daniel
name: Narendra, Julia H.
name: Building Research Capacity in the Dialysis Community at the Local Level Stakeholder Workshop Participants
name: Dember, Laura M.
name: Wilkie, Caroline
name: Dorough, Adeline
name: Frazier, Karen
name: Flythe, Jennifer E.
name: Ikeler, Kourtney
name: Amolegbe, Andrew
Publisher: name: Wolters Kluwer
Year: 2019

description: Individuals with kidney failure receiving dialysis have high morbidity and mortality rates and their condition is associated with poor health-related quality of life.
Cyclical Exacerbation of Suicidal Ideation in Female Outpatients: Prospective Evidence From Daily Ratings in a Transdiagnostic Sample
Creators: name: Eisenlohr-Moul, Tory A.
name: Schmalenberger, Katja M.
name: Bowers, Savannah
name: Girdler, Susan S.
name: Prinstein, Mitchell J.
name: Rubinow, David R.
name: Owens, Sarah A.
Publisher: name: American Psychological Association (APA)
Year: 2023

description: Suicide is a leading cause of death among females of reproductive age. The menstrual cycle is a plausible yet understudied trigger for acute suicide risk. Cross-sectional studies have demonstrated a greater frequency of suicide attempts and deaths in the weeks before and after the onset of menses compared to other cycle phases. Here, using prospective daily ratings, we examine the relationship between the cycle and suicidal ideation (SI) and related symptoms known to show a cyclical change in some patients (depression, hopelessness, guilt, rejection sensitivity, interpersonal conflict, anxiety, mood swings, and anger/irritability). Thirty-eight naturally cycling outpatients recruited for past-month SI reported SI severity and other symptoms across an average of 40 days. Participants were excluded for hormone use, pregnancy, irregular cycles, serious medical illness, and body mass index > 29.9 or < 18. Intraclass correlations ranged from .29 to .46, highlighting that most symptom variance lies within-person. Cyclical worsening of symptoms was evaluated using phase contrasts in multilevel models. Most symptoms, including SI, were significantly worse in the perimenstrual phase than in all other phases. Additionally, anger/irritability was higher in the midluteal than in the midfollicular phase, and several symptoms of depression were higher in the midfollicular than in the periovulatory phase. Otherwise, symptoms did not significantly differ between the midluteal, midfollicular, and periovulatory phases. Cycle phase predictors accounted for 25% of the within-person variance in SI. Females with SI may be at risk for perimenstrual worsening of SI and related symptoms. These findings highlight the importance of assessing the cycle phase for improved prediction of suicide risk.
Geflohen Aus Eritrea, Aufgenommen In Der Schweiz: Möglichkeiten Der Sozialen Arbeit Zur Förderung Einer Gelingenden Integration Der Eritreischen Flüchtlinge Und Vorläufig Aufgenommenen In Der Schweiz
Creators: name: Bachmann, Christian
name: Metzger, Philipp
Publisher: name: Zenodo
Year: 2011
Subjects: subject: gnd:4055676-1
subject: gnd:4017604-6
subject: gnd:4015278-9
subject: gnd:4053881-3

description: Die vorliegende Bachelor-Arbeit behandelt die Möglichkeiten der Sozialen Arbeit, eine gelingende sprachliche, berufliche und gesellschaftliche Integration der eritreischen Flüchtlinge und vorläufig aufgenommenen Personen in der Schweiz zu fördern. In den letzten Jahren sind immer mehr Eritreerinnen und Eritreer in die Schweiz geflüchtet. Die meisten haben die Aussicht, dauerhaft im Land zu bleiben. Entsprechend zentral sind adäquate Integrationsstrategien, mit denen nachhaltige Perspektiven für diese Personen generiert werden können. Die Autoren entwickeln unter Einbezug von Theorien des Soziologen Pierre Bourdieu eine Auswahl an Handlungsempfehlungen, mit deren Umsetzung die Professionellen der Sozialen Arbeit den Integrationsprozess von eritreischen Flüchtlingen und vorläufig aufgenommenen Personen unterstützen können. Die empfohlenen Massnahmen basieren auf der Analyse der aktuellen rechtlichen und sozioökonomischen Rahmenbedingungen in der Aufnahmegesellschaft sowie auf der Analyse des herkunftsgesellschaftlichen Kontextes, der soziodemographischen Angaben und der genderspezifischen Eigenschaften der Eritreerinnen und Eritreer. Die Analyse zeigt auf, dass die meist jungen und mehrsprachigen Flüchtlinge und vorläufig aufgenommenen Personen aus Eritrea über vielfältige Ressourcen verfügen. Werden diese Ressourcen durch die Professionellen der Sozialen Arbeit adäquat gefördert, können sie den Eritreerinnen und Eritreern eine Teilhabe am wirtschaftlichen, kulturellen und sozialen Leben in der Schweiz ermöglichen.
description: + Code Diss LU: hslusa basa 2011 + Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit, 2011
66250: Letter: To Marion Scott.
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Includes 'To England: A Note' / not much to do as a signaller / describes writing under attack / quotes the poet John Masefield on Shakespeare / includes a musical score entitled 'Sea Symphony' / the state of the dugout and hygiene at the front / pipes and sunsets / Milton / quotes an unknown poem / describes just escaping from a strafe / German vs. English explosives / instructions regarding a parcel from Marion Scott / the courage and humour of the men / pleasure over a trench journal, the 'Somewhere in France Gazette' / loss of a friend to hospital / things starting to 'move' regarding Russian, etc. / Bach / aeroplanes and a musical score / poppies. | File description(s):Envelope containing letter.
Includes 'To England - A Note' / not much to do as a signaller / describes writing under attack / quotes the poet John Masefield on Shakespeare / includes a musical score entitled 'Sea Symphony' / the state of the dugout and hygiene at the front / pipes and sunsets / Milton / quotes an unknown poem / describes just escaping from a strafe / German vs. English explosives / instructions regarding a parcel from Marion Scott / the courage and humour of the men / pleasure over a trench journal, the 'Somewhere in France Gazette' / loss of a friend to hospital / things starting to 'move' regarding Russian, etc. / Bach / aeroplanes and a musical score / poppies.
Includes 'To England: A Note' / not much to do as a signaller / describes writing under attack / quotes the poet John Masefield on Shakespeare / includes a musical score entitled 'Sea Symphony' / the state of the dugout and hygiene at the front / pipes and sunsets / Milton / quotes an unknown poem / describes just escaping from a strafe / German vs. English explosives / instructions regarding a parcel from Marion Scott / the courage and humour of the men / pleasure over a trench journal, the 'Somewhere in France Gazette' / loss of a friend to hospital / things starting to 'move' regarding Russian, etc. / Bach / aeroplanes and a musical score / poppies.
A 185 Kg Nai[Tl] Detector For Observing The Charged-Current Neutrino Interaction On $^{127}$I
Creators: name: HEDGES, Samuel
Publisher: name: Zenodo
Year: 2018

description: A 185 kg NaI[Tl] detector has been deployed to the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL) to measure the charged-current neutrino interaction cross section on 127
^{127}
I. Results from an initial run will be shown, as well as improvements from a recent upgrade in which muon vetos were deployed to reduce backgrounds. In addition to measuring the charged-current interaction, the 185 kg detector is also measuring low energy backgrounds in the region of interest for observing coherent elastic neutrino-nucleus scattering of 23
^{23}
Na nuclei. A tonne-scale version of the detector is currently being developed with the capability to simultaneously observe these two interactions.
De novo compartment deconvolution and weight estimation of tumor samples using DECODER
Creators: name: Yeh, Jen Jen
name: Peng, Xianlu Laura
name: Torphy, Robert J.
name: Volmar, Keith E.
name: Moffitt, Richard A.
Publisher: name: Springer Nature
Year: 2019

description: Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the ability to breakdown the gene expression contribution of each is critical. Here, we develop DECODER, an integrated framework which performs de novo deconvolution and single-sample compartment weight estimation. We use DECODER to deconvolve 33 TCGA tumor RNA-seq data sets and show that it may be applied to other data types including ATAC-seq. We demonstrate that it can be utilized to reproducibly estimate cellular compartment weights in pancreatic cancer that are clinically meaningful. Application of DECODER across cancer types advances the capability of identifying cellular compartments in an unknown sample and may have implications for identifying the tumor of origin for cancers of unknown primary.
First $\Nu_{\Mu}$ + $\Bar{\Nu}_{\Mu}$ Disappearance Results From The Nova Experiment
Creators: name: MENDEZ, Diana Patricia
Publisher: name: Zenodo
Year: 2018

description: NOvA is a long-baseline neutrino oscillation experiment measuring νμ
\nu_{\mu}
disappearance and νe
\nu_e
appearance within the NuMI beam from Fermilab. The experiment uses a Near and a Far Detector placed 810 km away from each other and at 14 milliradians off the beam-axis resulting in an observed energy spectrum that peaks at 2 GeV, close to the oscillation maximum.

A combined νμ
\nu_{\mu}
+ ν¯μ
\bar\nu_{\mu}
disappearance result will be presented including NOvA's first collected anti-neutrino data for a total exposure of 16×1020
16\times10^{20}
protons-on-target which, in addition to an upgraded analysis, will enable the experiment to set new limits to the allowed regions for Δm232
\Delta m^2_{32}
and sin2θ23
^2\theta_{23}
and make a measurement of Δm232
\Delta m^2_{32}
among the world's best.
Cumulative Exposure to Frequent Intradialytic Hypotension Associates With New-Onset Dementia Among Elderly Hemodialysis Patients
Creators: name: Wang, Lily
name: Assimon, Magdalene M.
name: Flythe, Jennifer E.
Publisher: name: Elsevier
Year: 2019

description: To the Editor: Cognitive impairment, including dementia, affects up to 70% of individuals receiving maintenance hemodialysis, a prevalence that exceeds that of the elderly general population by 3- to 7-fold. Cardiometabolic risk factors for dementia, such as diabetes, hypercholesterolemia, hypertension, and vascular disease, are highly prevalent in end-stage kidney disease. However, the rate of new-onset dementia is higher among hemodialysis patients compared with peritoneal dialysis patients, suggesting that aspects of the hemodialysis procedure may contribute to the development of dementia.
Systèmes Agroalimentaires Localisés et jeu d’acteurs : Une application de la méthode MACTOR au Système Productif de l’Attiéké dans la localité de Dabou en Côte d’Ivoire
Creators: name: YEO, Kanigui
name: BENCHEKARA, Mohammed
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Systèmes Agroalimentaires Localisés, manioc, Attiéké, Jeu d’acteurs, Méthode MACTOR.

description: Les Systèmes Agroalimentaires Localisés (SYAL), dont les bases théoriques ont été lancées dans les années 1990/1996 par le CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement), apparaissent à bien des égards comme une forme d’organisation productive qui serait capable de faire un rapprochement entre le territoire, l’activité agricole et les produits agro alimentaires. Dans leur définition, l’intéraction entre les acteurs constitue un élément d’appreciation important. C’est pourquoi nous avons identifié dans la localité de Dabou en Côte d’Ivoire, un SYAL autout de l’Attiéké et nous nous proposons d’analyser la dynamique et la mobilisation de ses acteurs en utilisant la méthode MACTOR.
description: Revue Economie, Gestion et Société, No 4 (2015)
De novo design of stable proteins that efficaciously inhibit oncogenic G proteins
Creators: name: Kuhlman, Brian
name: Tripathy, Ashutosh
name: Sondek, John
name: Cummins, Matthew C.
Publisher: name: Wiley
Year: 2023

description: Many protein therapeutics are competitive inhibitors that function by binding to endogenous proteins and preventing them from interacting with native partners. One effective strategy for engineering competitive inhibitors is to graft structural motifs from a native partner into a host protein. Here, we develop and experimentally test a computational protocol for embedding binding motifs in de novo designed proteins. The protocol uses an "inside-out" approach: Starting with a structural model of the binding motif docked against the target protein, the de novo protein is built by growing new structural elements off the termini of the binding motif. During backbone assembly, a score function favors backbones that introduce new tertiary contacts within the designed protein and do not introduce clashes with the target binding partner. Final sequences are designed and optimized using the molecular modeling program Rosetta. To test our protocol, we designed small helical proteins to inhibit the interaction between Gαq and its effector PLC-β isozymes. Several of the designed proteins remain folded above 90°C and bind to Gαq with equilibrium dissociation constants tighter than 80nM. In cellular assays with oncogenic variants of Gαq , the designed proteins inhibit activation of PLC-β isozymes and Dbl-family RhoGEFs. Our results demonstrate that computational protein design, in combination with motif grafting, can be used to directly generate potent inhibitors without further optimization via high throughput screening or selection.
Constructing Meaning through Organisations and Law: An Analysis of the Due Diligence Defence for Prospectus Misstatements and Omissions Liability in the United States, the United Kingdom and Australia
Creators: name: IMBULAGODAGE DONA RANGIKA RASANJALI PALLIYAARACHCHI
Publisher: name: Monash University
Year: 2020
Subjects: subject: Law
subject: FOS: Law

description: This thesis analyses how the meaning and content of due diligence defence in prospectus misstatements and omissions liability have been constructed in three jurisdictions: the United States, the United Kingdom and Australia. The conceptual model of Lauren B Edelman is adopted in this thesis emphasising the organisational and institutional influences in the law-making process. This enables new insights to be gained on the evolution of the DDD in common law countries. It also reveals the important role of organisations, rather than the judiciary or regulators, in constructing the meaning and content of securities laws across all three countries.
Deep Learning-driven research for drug discovery: Tackling Malaria
Creators: name: Lima, Mar­lia N. N.
name: Alves, Vinicius M.
name: Neves, Bruno J.
name: Andrade, Carolina Horta
name: Muratov, Eugene N.
name: Braga, Rodolpho C.
name: Costa, Fabio T. M.
name: Cassiano, Gustavo C.
Publisher: name: Public Library of Science (PLoS)
Year: 2020

description: Malaria is an infectious disease that affects over 216 million people worldwide, killing over 445,000 patients annually. Due to the constant emergence of parasitic resistance to the current antimalarial drugs, the discovery of new drug candidates is a major global health priority. Aiming to make the drug discovery processes faster and less expensive, we developed binary and continuous Quantitative Structure-Activity Relationships (QSAR) models implementing deep learning for predicting antiplasmodial activity and cytotoxicity of untested compounds. Then, we applied the best models for a virtual screening of a large database of chemical compounds. The top computational predictions were evaluated experimentally against asexual blood stages of both sensitive and multi-drug-resistant Plasmodium falciparum strains. Among them, two compounds, LabMol-149 and LabMol-152, showed potent antiplasmodial activity at low nanomolar concentrations (EC50 <500 nM) and low cytotoxicity in mammalian cells. Therefore, the computational approach employing deep learning developed here allowed us to discover two new families of potential next generation antimalarial agents, which are in compliance with the guidelines and criteria for antimalarial target candidates.
Le Rôle de l’assurance maladie obligatoire dans le financement des soins de santé au Maroc : état des lieux et perspective d’évolution
Creators: name: BELMAATI, Hicham
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Assurance maladie, performance, système de financement de la santé, régime à payeur multiples, régime à payeur unique.

description: Nous présentons dans ce papier le rôle de l’assurance maladie obligatoire au Maroc comme mécanisme de solidarité, permettant l’accès des citoyens aux soins de santé. Et cela à travers, tout d’abord, l’évaluation de sa performance en tant que composante du système de financement de la santé, ensuite, la réflexion sur une éventuelle réforme en envisageant deux scénarios : - garder une configuration avec un régime à multiples payeurs, ou instaurer un régime à payeur unique.
description: Revue Economie, Gestion et Société, No 4 (2015)
Development and Validation of the Trust in My Doctor, Trust in Doctors in General, and Trust in the Health Care Team Scales
Creators: name: Boynton, Marcella H
name: Ozawa, Sachiko
name: Muessig, Kathryn E
name: Richmond, Jennifer
name: Ribisl, Kurt M
name: Cykert, Samuel
Publisher: name: Elsevier
Year: 2022

description: RATIONALE: Historic and present-day racism and inequity in the United States (U.S.) have resulted in diminished trust in health care among many populations. A key barrier to improving trust in health care is a dearth of well-validated measures appropriate for diverse populations. Indeed, systematic reviews indicate a need to develop and test updated trust measures that are multidimensional and inclusive of relevant domains (e.g., fairness). OBJECTIVE: We developed three trust measures: the Trust in My Doctor (T-MD), Trust in Doctors in General (T-DiG), and Trust in the Health Care Team (T-HCT) scales. METHODS: After developing an initial item pool, expert reviewers (n = 6) provided feedback on the face validity of each scale. We conducted cognitive interviews (n = 21) with a convenience sample of adults to ensure items were interpreted as intended. In 2020, we administered an online survey to a convenience sample of U.S. adults recruited through the Qualtrics Panel (n = 801) to assess scale reliability and validity. RESULTS: Exploratory and confirmatory factor analyses indicated acceptable model fit for second order latent factor models for each scale (root mean square error of approximation: <0.07, comparative fit index: ≥0.98, and standardized root mean square residual: ≤0.03). The T-MD contained 25 items and six subscales: communication competency, fidelity, systems trust, confidentiality, fairness, and global trust. The T-DiG and T-HCT each contained 29 items and seven subscales (the same subscales in the T-MD plus an additional subscale related to stigma-based discrimination). Each scale was strongly correlated with existing trust measures and perceived racism in health care and was significantly associated with delayed health care seeking and receipt of a routine health exam. CONCLUSIONS: The multidimensional T-MD, T-DiG, and T-HCT scales have sound psychometric properties and may be useful for researchers evaluating trust-related interventions or conducting studies where trust is an important construct or main outcome.
Development of a person-centered interdisciplinary plan-of-care program for dialysis
Creators: name: Mold, James W
name: Dorough, Adeline
name: Kshirsagar, Abhijit V
name: Forfang, Derek
name: Murphy, Shannon L
name: Flythe, Jennifer E
name: DeWalt, Darren A
Publisher: name: Oxford University Press (OUP)
Year: 2020

description: BACKGROUND: Dialysis care often focuses on outcomes that are of lesser importance to patients than to clinicians. There is growing international interest in individualizing care based on patient priorities, but evidence-based approaches are lacking. The objective of this study was to develop a person-centered dialysis care planning program. To achieve this objective we performed qualitative interviews, responsively developed a novel care planning program and then assessed program content and burden. METHODS: We conducted 25 concept elicitation interviews with US hemodialysis patients, care partners and care providers, using thematic analysis to analyze transcripts. Interview findings and interdisciplinary stakeholder panel input informed the development of a new care planning program, My Dialysis Plan. We then conducted 19 cognitive debriefing interviews with patients, care partners and care providers to assess the program's content and face validities, comprehensibility and burden. RESULTS: We identified five themes in concept elicitation interviews: feeling boxed in by the system, navigating dual lives, acknowledging an evolving identity, respecting the individual as a whole person and increasing individualization to enhance care. We then developed a person-centered care planning program and supporting materials that underwent 32 stakeholder-informed iterations. Data from subsequent cognitive interviews led to program revisions intended to improve contextualization and understanding, decrease burden and facilitate implementation. CONCLUSIONS: My Dialysis Plan is a content-valid, person-centered dialysis care planning program that aims to promote care individualization. Investigation of the program's capacity to improve patient experiences and outcomes is needed.
Metadata For The Multilingual Web
Creators: name: Sasaki, Felix
Publisher: name: Zenodo
Year: 2018

description: We describe the Internationalization Tag Set (ITS) 2.0, an upcoming standard to

foster the development of the multilingual Web. its 2.0 provides metadata to integrate workflows for content production, localization and language technology. The

technical goal is to achieve better results in content creation and other language-

related processes; the goal in terms of community building is to raise awareness of

needs in multilingual workflows. This aim is also supported by providing re-usable

software components for various use cases.
LA QUALITE AU COEUR DU PROJET D’ENTREPRISE
Creators: name: KHALOUKI, Hassan
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Gestion, qualité, entreprise, relation client, mutation, compétitivité.

description: Le présent article est une simple contribution à l’étude de la relation entre la gestion de la qualité et la qualité de la gestion en tant qu’instrument de management, pour conclure que si la gestion de la qualité est nécessaire, elle n’est pas un instrument de gestion et qu’il ne semble pas exister un système de gestion idéal de la qualité.
description: Revue Economie, Gestion et Société, No 4 (2015)
Development of a preliminary conceptual model of the patient experience of chronic kidney disease: a targeted literature review and analysis
Creators: name: Sundgren, Anna
name: Cremisi, Henry
name: Flythe, Jennifer E.
name: Grandinetti, Amanda
name: Cordero, Paul
name: Ryden, Anna
name: Karlsson, Niklas
Publisher: name: Springer Nature
Year: 2021

description: BackgroundPatient-reported outcome (PRO) instruments should capture the experiences of disease and treatment that patients consider most important in order to inform patient-centred care and product development. The aim of this study was to develop a preliminary conceptual model of patient experience in chronic kidney disease (CKD) based on a targeted literature review and to characterize existing PRO instruments used in CKD.MethodsPubMed, EMBASE and Cochrane databases and recent society meetings were searched for publications reporting signs/symptoms and life impacts of CKD. Concepts identified in the literature review were used to develop a preliminary conceptual model of patient experience of CKD, overall, and within patient subpopulations of differing CKD causes, severities and complications. PRO instruments, identified from PRO databases, CKD literature and CKD clinical trials, were assessed for content validity, psychometric strength and coverage of concepts in the literature review.ResultsIn total, 100 publications met criteria for analysis; 56 signs/symptoms and 37 life impacts of CKD were identified from these sources. The most frequently mentioned signs/symptoms were pain/discomfort (57% of publications) and tiredness/low energy/lethargy/fatigue (42%); the most commonly reported life impacts were anxiety/depression (49%) and decrements in physical functioning (43%). Signs/symptoms and life impacts varied across the subpopulations and were more frequent at advanced CKD stages. The preliminary conceptual model grouped signs/symptoms into seven domains (pain/discomfort; energy/fatigue; sleep-related; gastrointestinal-related; urinary-related; skin-/hair-/nails-related; and other) and life impacts into six domains (psychological/emotional strain; cognitive impairment; dietary habit disruption; physical function decrements; interference with social relationships; and other). Eleven PRO instruments were considered to be promising for use in CKD; all had limitations.ConclusionsAlthough preliminary, the proposed conceptual model highlights key PROs for people with CKD and is intended to spur development of more tailored PRO instruments to assess these concepts.
State Of The Art In Translation Memory Technology
Creators: name: Reinke, Uwe
Publisher: name: Zenodo
Year: 2018

description: Commercial Translation Memory systems (tm) have been available on the market

for over two decades now. They have become the major language technology to

support the translation and localization industries. The following paper will provide an overview of the state of the art in tm technology, explaining the major concepts and looking at recent trends in both commercial systems and research. The

paper will start with a short overview of the history of tm systems and a description of their main components and types. It will then discuss the relation between

tm and machine translation (mt) as well as ways of integrating the two types of

translation technologies. After taking a closer look at data exchange standards relevant to tm environments, the focus of the paper then shifts towards approaches

to enhance the retrieval performance of tm systems looking at both non-linguistic

and linguistic approaches.
Dialysis Care around the World: A Global Perspectives Series.
Creators: name: Lee, Timmy
name: Flythe, Jennifer E
name: Allon, Michael
Publisher: name: Wolters Kluwer
Year: 2021

description: Introduction Worldwide, ESKD prevalence per million population (PMP) has steadily increased from 2003 to 2016 (1), with the greatest proportional increases occurring in lower- and middle-income countries (2). Although dialysis is a lifesaving therapy, it is also extraordinarily expensive, so its use is limited in lower-income countries with less resources available for healthcare. Specifically, the prevalence of dialysis in 2010 was 1176 PMP in higher-income countries, 688 PMP in upper-middle-income countries, 170 PMP in lowerincome countries, and 16 PMP in lower-income countries (2). The most common modality of kidney replacement therapy globally is dialysis (78%) and, among patients receiving dialysis, only 11% receive peritoneal dialysis (3)
المثقف والمجتمع والسلطة
Creators: name: ACHAHBOUN, Zoubida
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Governor mechanisms, intellectual, circumstantial time, the authority of intellectuals, community, power, thinker.

description: Control mechanisms of cultured stronger mechanisms of the ruling, and the intelligence and the intelligence of the largest of the ruling and intellectual thinking and analyzes and disassembles predicts. Is characterized by far-sighted and Ruwayyah and poise, puts all the possibilities and offers solutions for every eventuality, it is the flame of a volcano of ideas, explosive constantly, spring does not dry and inexhaustible, and therein lies the strength of intellectual power, while the ruling is thinking not only for reflection but from for activation sentenced Bzervih short time becoming capsize all the balances. The governor may use his intelligence or cunning in trivial things have been achieved his goals is governed by time, it may act Bandfaih based violence and savvy and cunning. Here and do not forget Prince Machiavelli in his book: How can the governor to extend his rule its use of all roads, Alice is that the end justifies the means this word that lacking in intellectual base.
description: Revue Economie, Gestion et Société, No 4 (2015)
Additional file 1 of Maternal and neonatal complications after IVF/ICSI-fresh embryo transfer in low-prognosis women under the POSEIDON criteria: a retrospective cohort study
Creators: name: Li, Shiguang
name: Tan, Huifang
name: Fu, Huimin
name: Du, Juan
name: Liu, Peihao
name: Qin, Yingying
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 1.
Detecting Supernova Neutrino Bursts With Sk-Gd Prototype: Egads
Creators: name: PRONOST, Guillaume
Publisher: name: Zenodo
Year: 2018

description: EGADS is the successful prototype of the Super-Kamiokande Gd project (SK-Gd). It is now converted as a standalone supernova (SN) detector. EGADS will serve as a backup for the SK detector this summer, when the SK tank will be opened for inspection and refurbishing. After SK tank work, it will provide automatic and immediate notification to the full community in case of a SN ν
\nu
burst detection.

The EGADS DAQ is able to handle high rate bursts of events in the detector (500k events in 10 sec). In addition, the Gd loading of the water reduces the background thanks to the delayed coincidence of the inverse β
\beta
decay reaction with the clear signal from the Gd neutron capture. These features allow EGADS to detect SN ν
\nu
bursts from stars as close as Betelgeuse to stars in the whole Milky Way.

In this poster we present the up-to-date capacities of the EGADS detector in terms of SN ν
\nu
bursts detection, as well as the details and the status of its online SN alarm system.
sj-docx-4-jmq-10.1177_10776990221093930 – Supplemental material for Moderation Effects of Language Skills, Residential Tenure, and Education on Immigrants’ Learning From News
Creators: name: Medvedeva, Yulia S.
name: Leshner, Glenn M.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Education

description: Supplemental material, sj-docx-4-jmq-10.1177_10776990221093930 for Moderation Effects of Language Skills, Residential Tenure, and Education on Immigrants’ Learning From News by Yulia S. Medvedeva and Glenn M. Leshner in Journalism & Mass Communication Quarterly
SO`Z YASALISH TIZIMINING TILSHUNOSLIKDA O`RGANILISHI. DERIVATSIYA VA OKKOZIONALIZM
Creators: name: UMAROVA, XILOLAXON
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola orqali so`z yasalishining tilshunoslikda o`rganilishi va okkozionialzmga ta’siri o`rganilgan. Shuningdek, derivatsiyaning turlari , okkozional so`zlarning hosil bo`lishida derivatsiyaning o`rni o`rganilgan.
Supplemental Material - Key Elements and Mechanisms of a Peer-Support Intervention to Reduce Loneliness and Isolation among Low-Income Older Adults: A Qualitative Implementation Science Study
Creators: name: Fuller, Shannon M.
name: Kotwal, Ashwin A.
name: Tha, Soe Han
name: Hill, Daniel
name: Perissinotto, Carla
name: Myers, Janet J.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material for Key Elements and Mechanisms of a Peer-Support Intervention to Reduce Loneliness and Isolation among Low-Income Older Adults: A Qualitative Implementation Science Study by Shannon M. Fuller, Ashwin A. Kotwal, Soe Han Tha, Daniel Hill, Carla Perissinotto and Janet J. Myers in Journal of Applied Gerontology
Additional file 2 of Maternal and neonatal complications after IVF/ICSI-fresh embryo transfer in low-prognosis women under the POSEIDON criteria: a retrospective cohort study
Creators: name: Li, Shiguang
name: Tan, Huifang
name: Fu, Huimin
name: Du, Juan
name: Liu, Peihao
name: Qin, Yingying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 2.
Dialysis-associated allergic reactions during continuous renal replacement therapy and hemodialysis: A case report
Creators: name: Flythe, Jennifer E.
name: Chen, Dhruti P.
Publisher: name: Wiley
Year: 2019

description: Dialyzer reactions are long-appreciated complications of dialysis. Despite advances in dialysis machines and membranes, these life-threatening reactions still occur. It is imperative to recognize potential dialyzer reactions when assessing adverse dialysis events as reexposure to dialytic treatments could be life threatening. We present the case of a 72-year old woman with dialysis-requiring anuric acute kidney injury who experienced acute hypotension and cardiopulmonary arrest during both continuous renal replacement therapy and a subsequent hemodialysis treatment. We concluded that she had an anaphylactic reaction to an unidentified component of the dialysis equipment. Identification, work up, treatment, and reporting of dialyzer reactions are discussed in the context of this case.