Brain charts for the human lifespan
Creators: name: Bethlehem, RAI
name: Seidlitz, J
name: White, 
name: Vogel, JW
name: Anderson, KM
name: Adamson, C
name: Adler, S
name: Alexopoulos, GS
name: Anagnostou, E
name: Areces-Gonzalez, A
name: Astle, DE
name: Auyeung, B
name: Ayub, M
name: Ball, G
name: Baron-Cohen, S
name: Beare, R
name: Bedford, SA
name: Benegal, V
name: Beyer, F
name: Bin Bae, J
name: Blangero, J
name: Blesa Cábez, M
name: Boardman, JP
name: Borzage, M
name: Bosch-Bayard, JF
name: Bourke, N
name: Calhoun, VD
name: Chakravarty, MM
name: Chen, C
name: Chertavian, C
name: Chetelat, G
name: Chong, YS
name: Cole, JH
name: Corvin, A
name: Courchesne, E
name: Crivello, F
name: Cropley, VL
name: Crosbie, J
name: Crossley, N
name: Delarue, M
name: Desrivieres, S
name: Devenyi, G
name: Di Biase, MA
name: Dolan, R
name: Donald, KA
name: Donohoe, G
name: Dunlop, K
name: Edwards, AD
name: Elison, JT
name: Ellis, CT
name: Elman, JA
name: Eyler, L
name: Fair, DA
name: Fletcher, PC
name: Fonagy, P
name: Franz, CE
name: Galan-Garcia, L
name: Gholipour, A
name: Giedd, J
name: Gilmore, JH
name: Glahn, DC
name: Goodyer, I
name: Grant, PE
name: Groenewold, NA
name: Gunning, FM
name: Gur, RE
name: Gur, RC
name: Hammill, CF
name: Hansson, O
name: Hedden, T
name: Heinz, A
name: Henson, R
name: Heuer, K
name: Hoare, J
name: Holla, B
name: Holmes, AJ
name: Holt, R
name: Huang, H
name: Im, K
name: Ipser, J
name: Jack, CR
name: Jackowski, AP
name: Jia, T
name: Johnson, KA
name: Jones, PB
name: Jones, DT
name: Kahn, R
name: Karlsson, H
name: Karlsson, L
name: Kawashima, R
name: Kelley, EA
name: Kern, S
name: Kim, K
name: Kitzbichler, MG
name: Kremen, WS
name: Lalonde, F
name: Landeau, B
name: Lee, S
name: Lerch, J
name: Lewis, JD
name: Li, J
name: Liao, W
name: Linares, DP
name: Liston, C
name: Lombardo, MV
name: Lv, J
name: Lynch, C
name: Mallard, TT
name: Marcelis, M
name: Markello, RD
name: Mazoyer, B
name: McGuire, P
name: Meaney, MJ
name: Mechelli, A
name: Medic, N
name: Misic, B
name: Morgan, SE
name: Mothersill, D
name: Nigg, J
name: Ong, MQW
name: Ortinau, C
name: Ossenkoppele, R
name: Ouyang, M
name: Palaniyappan, L
name: Paly, L
name: Pan, PM
name: Pantelis, C
name: Park, MM
name: Paus, T
name: Pausova, Z
name: Pichet Binette, A
name: Pierce, K
name: Qian, X
name: Qiu, J
name: Qiu, A
name: Raznahan, A
name: Rittman, T
name: Rollins, CK
name: Romero-Garcia, R
name: Ronan, L
name: Rosenberg, MD
name: Rowitch, DH
name: Salum, GA
name: Satterthwaite, TD
name: Schaare, HL
name: Schachar, RJ
name: Schultz, AP
name: Schumann, G
name: Schöll, M
name: Sharp, D
name: Shinohara, RT
name: Skoog, I
name: Smyser, CD
name: Sperling, RA
name: Stein, DJ
name: Stolicyn, A
name: Suckling, J
name: Sullivan, G
name: Taki, Y
name: Thyreau, B
name: Toro, R
name: Tsvetanov, KA
name: Turk-Browne, NB
name: Tuulari, JJ
name: Tzourio, C
name: Vachon-Presseau, É
name: Valdes-Sosa, MJ
name: Valdes-Sosa, PA
name: Valk, SL
name: Van Amelsvoort, T
name: Vandekar, SN
name: Vasung, L
name: Victoria, LW
name: Villeneuve, S
name: Villringer, A
name: Vértes, PE
name: Wagstyl, K
name: Wang, YS
name: Warfield, SK
name: Warrier, V
name: Westman, E
name: Westwater, ML
name: Whalley, HC
name: Witte, AV
name: Yang, N
name: Yeo, BTT
name: Yun, HJ
name: Zalesky, A
name: Zar, HJ
name: Zettergren, A
name: Zhou, JH
name: Ziauddeen, H
name: Zugman, A
name: Zuo, XN
name: Alexander-Bloch, AF
name: AIBL
name: Alzheimer’s Disease Neuroimaging Initiative
name: Alzheimer’s Disease Repository Without Borders Investigators
name: ASRB
name: CALM Team
name: Cam-CAN
name: CCNP, 3R-BRAIN
name: COBRE
name: ENIGMA Developmental Brain Age Working Group
name: FinnBrain
name: Harvard Aging Brain Study
name: IMAGEN, KNE96
name: NSPN
name: OASIS-3
name: OpenPain Project
name: POND
name: The PREVENT-AD Research Group, VETSA
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Brain
Humans
Magnetic Resonance Imaging
Body Height
Longevity
Neuroimaging

description: Funder: Wellcome Trust
description: Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource ( www.brainchart.io ) to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study, against models of expected age-related trends. With the goal of basing these on the largest and most inclusive dataset, we aggregated MRI data spanning 115 days post-conception through 100 postnatal years, totaling 122,123 scans from 100,071 individuals in over 100 studies across 6 continents. When quantified as centile scores relative to the reference models, individual differences show high validity with non-MRI brain growth estimates and high stability across longitudinal assessment. Centile scores helped identify previously unreported brain developmental milestones and demonstrated increased genetic heritability compared to non-centiled MRI phenotypes. Crucially for the study of brain disorders, centile scores provide a standardised and interpretable measure of deviation that reveals new patterns of neuroanatomical differences across neurological and psychiatric disorders emerging during development and ageing. In sum, brain charts for the human lifespan are an essential first step towards robust, standardised quantification of individual variation and for characterizing deviation from age-related trends. Our global collaborative study provides such an anchorpoint for basic neuroimaging research and will facilitate implementation of research-based standards in clinical studies.