cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
Creators: name: Nyante, Sarah J.
name: Millikan, Robert C.
name: Hu, Yijuan
name: Barnholtz-Sloan, Jill S.
name: Lin, Dan Yu
name: Kaufman, Jay S.
name: Bensen, Jeannette T.
name: He, Qianchuan
name: Gammon, Marilie D.
name: Luo, Jingchun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Adipocytokines are produced by visceral fat, and levels may be associated with breast cancer risk. We investigated whether single nucleotide polymorphisms (SNPs) in adipocytokine genes adiponectin (ADIPOQ), leptin (LEP), and the leptin receptor (LEPR) were associated with basal-like or luminal A breast cancer subtypes. 104 candidate and tag SNPs were genotyped in 1776 of 2022 controls and 1972 (200 basal-like, 679 luminal A) of 2311 cases from the Carolina Breast Cancer Study (CBCS), a population-based case–control study of whites and African Americans. Breast cancer molecular subtypes were determined by immunohistochemistry. Genotype odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Haplotype ORs and 95% CIs were estimated using Hapstat. Interactions with waist-hip ratio were evaluated using a multiplicative interaction term. Ancestry was estimated from 144 ancestry informative markers (AIMs), and included in models to control for population stratification. Candidate SNPs LEPR K109R (rs1137100) and LEPR Q223R (rs1137101) were positively associated with luminal A breast cancer, whereas ADIPOQ +45 T/G (rs2241766), ADIPOQ +276 G/T (rs1501299), and LEPR K656N (rs8129183) were not associated with either subtype. Few patterns were observed among tag SNPs, with the exception of 3 LEPR SNPs (rs17412175, rs9436746, and rs9436748) that were in moderate LD and inversely associated with basal-like breast cancer. However, no SNP associations were statistically significant after adjustment for multiple comparisons. Haplotypes in LEP and LEPR were associated with both basal-like and luminal A subtypes. There was no evidence of interaction with waist-hip ratio. Data suggest associations between LEPR candidate SNPs and luminal A breast cancer in the CBCS and LEPR intron 2 tag SNPs and basal-like breast cancer. Replication in additional studies where breast cancer subtypes have been defined is necessary to confirm these potential associations.
title: Using Head Start Children's Language Development to Predict Social Information Processing Ability
Creators: name: Newman, Kendra
Publisher: name: Utah State University
Year: 2023

description: As young children grow and develop, gaining social skills and different language abilities is extremely important. As children develop, they also acquire the ability to process social information, which then helps them respond in various social situations. Children should eventually be able to respond to social situations in socially acceptable ways, instead of answering in aggressive or passive ways. This study examined the relations between children’s language development, and social information processing ability. This study included 51 children, from 19 Head Start classrooms. Results showed that at the beginning of the Head Start year children with more language, responded in more socially competent ways than children with less language. By the end of the Head Start year, this association was no longer significant. More research is needed to better understand the role of language development in children’s social information processing abilities.
title: Executive Functioning in Children With Autism and Co-Occurring Neurodevelopmental Disorders: A Systematic Review and Quantitative Analysis
Creators: name: Benallie, Kandice
Publisher: name: Utah State University
Year: 2023

description: Children with autism and other NDDs experience some level of executive dysfunction including challenges with problem-solving, judgement, working memory, and flexibility. Considering autism and other NDDs including ADHD and ID have overlapping symptoms, it can be difficult to differentially diagnose the disorders. This dissertation sought to explore how co-occurring ADHD and ID impact the EF of autistic children. The first study systematically reviewed the current research examining EF of autistic children with co-occurring ADHD and ID. Findings suggest that co-occurring ADHD and ID result in increased executive dysfunction as compared to children with autism only. The systematic review also revealed inconsistencies in the current literature as well as supported previous research suggesting that different ways of measuring EF (i.e., performance-based vs. indirect) are measuring different constructs of EF. This led to the second study which investigated whether intellectual functioning, autism symptomology, and ADHD symptomology predict EF in autistic children using an indirect measure of EF and (due to its ecological validity) and a model of EF (due to the overlapping nature of areas of EF). Results suggest that social communication difficulties and hyperactivity/impulsivity negatively impact EF whereas restricted/repetitive behaviors, inattention, and intellectual functioning do not significantly predict EF. Additionally, the student identified emotion regulation as a relative EF weakness as compared to behavior and cognitive regulation. Overall, this multi-part dissertation adds to the current literature by suggesting a co-occurring ADHD or ID worsens EF; suggested significant predictors of EF with autistic children (i.e., social communication challenges and hyperactivity/impulsivity); and, identified emotion regulation as a possible relative EF weakness. These results provide clinical application for differential diagnostic strategies and targeted interventions.
title: A Cohesive Simulation and Testing Platform for Civil Autonomous Aerial Sensing and Operations
Creators: name: Slack, Stockton G.
Publisher: name: Utah State University
Year: 2023

description: Drones (also known as sUAS or small Uncrewed Aerial Systems) are often flown with cameras to take images of an area of land. These images can then be used to create a map by stitching these images together. This map can then be analyzed using scientific principles to learn things about the land and make decisions or take action based on the information.
The scientific application of drones is very advantageous, but flying a drone is inherently dangerous, impacting the safety of the airspace (particularly in the event of a crash), and drones are more dangerous the bigger they are. Smaller off-the-shelf drones are readily available to the public and are quite safe and easy to use. Larger near 55-lb fixed-wing mapping drones that can fly for 2.5 hours are quite costly and bring new risks into the equation. There are many barriers and risks to being able to successfully test equipment and to improving drone mapping technology.
This research focuses on creating a simulator that can simulate the entire process of creating these scientific maps. Simulating a drone, a camera payload, and a world for the drone to fly over. By having a simulator, researchers will be able to test out new technologies without having to risk flying a drone or without having to overcome the challenges mentioned above.
This research also focuses on creating a smaller simple camera payload that can be attached to a drone for performing test flights. This allows researchers to do scientific tests without risking flying larger systems.
This work enables the testing of sUAS payload systems many times in the simulation and then, when the system works as it should, the test flights with an actual drone can commence. This reduces the amount of time it takes to develop scientific drone systems and reduces the risk of flight.
Race and age disparities in receipt of sentinel lymph node biopsy for early-stage breast cancer
Creators: name: Meyer, Anne Marie
name: Amos, Keith D.
name: Weiner, Bryan J.
name: Bainbridge, John
name: Godley, Paul A.
name: Carpenter, William R.
name: Reeder-Hayes, Katherine E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To evaluate differences in use of sentinel lymph node biopsy (SLNB) by age and race in Medicare recipients with early-stage breast cancer, we examined Surveillance, Epidemiology and End Results—Medicare linked data for women undergoing breast conserving surgery for stage I or II breast cancer, including axillary staging, between January 2000 and December 2002. Multivariable generalized linear modeling with generalized estimating equations was used to identify predictors of receiving SLNB versus standard axillary lymph node dissection as the primary axillary staging modality. Women were significantly less likely to receive SLNB as their primary staging procedure if they were African American (OR 0.65), greater than 80 years of age (OR 0.71 vs. age <70), or dually eligible for Medicare and Medicaid (OR 0.61). Tumor characteristics, including well-differentiated histology and stage I disease, were associated with increased likelihood of SLNB, but estrogen receptor status was not a significant predictor. Women treated at an institution affiliated with an NCI cooperative research group had significantly greater likelihood of receiving SLNB (OR 2.31). Likelihood of receiving SLNB increased for women diagnosed in 2001 and 2002 compared with 2000. Significant disparities exist in receipt of SLNB in the Medicare population, with African Americans, the elderly, and economically disadvantaged patients being less likely to receive this innovative and morbidity-sparing procedure. These findings continue a previously observed pattern of reduced access to state of the art breast cancer care among underserved populations.
title: All Good Women Are Mothers: Exploring Gender Binaries in How I Met Your Mother
Creators: name: Marinho, Jessica
Publisher: name: Utah State University
Year: 2023

description: Television is thought to be a form of entertainment through its many genres from comedy to drama, however, it is more than a relaxing pastime. Television series construct messages that influence audiences to accept specific behaviors. In this thesis, I analyzed the portrayal of the two main female characters in the popular television series How I Met Your Mother (2005-2009) and I argued how their depiction served to represent childless women as unwomanly and mothers as the ideal woman.
High x Structure Function of the Virtually Free Neutron
Creators: name: Cosyn, Wim
name: Sargsian, Misak M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The pole extrapolation method is applied to the semi-inclusive inelastic electron scattering off the deuteron with tagged spectator protons to extract the high-x structure function of the neutron. This approach is based on the extrapolation of the measured cross sections at different momenta of the spectator proton to the non-physical pole of the bound neutron in the deuteron. The advantage of the method is in the possibility of suppression of the nuclear effects in a maximally model-independent way. The neutron structure functions obtained in this way demonstrate a surprising x dependence at $x\ge 0.6$ and $1.6 \leq Q^2 \leq 3.38$ GeV$^2$, indicating a possible rise of the neutron to proton structure function ratio. If the observed rise is valid in the true deep inelastic region then it may indicate new dynamics in the generation of high-x quarks in the nucleon. One such mechanism we discuss is the possible dominance of short-range isosinglet quark-quark correlations that can enhance the d-quark distribution in the proton.
description: Seven pages and five figures. The version published in Phys. Rev. C 93, 055205 (2016)
title: The birth of 3 MAX microcatheter for mechanical thrombectomy, how far can it go?
Creators: name: Iturralde-Garriz, Amaya
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Ischaemia / Infarction
subject: Embolism / Thrombosis
subject: Technical aspects
subject: Catheters
subject: Arterial access
subject: MR
subject: CT-Angiography
subject: Catheter arteriography
subject: Vascular
subject: Neuroradiology brain
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - To present the experience of our center with a series of cases where the microcatheter 3MAX was used in the context of acute ischemic stroke with occlusion in distal vessels. -To show that the endovascular approach to thrombosis located beyond the...
title: Hybride Lehre in den Fächern und im Lehramt
Creators: name: Hochmuth, Reinhard
name: Becker, Tabea
name: Kempen, Leander
Year: 2022
Subjects: subject: 370 Erziehung, Schul- und Bildungswesen

description: Die Lehre an Hochschulen in Deutschland befindet sich gegenwärtig im Umbruch. Die Maßnahmen zur Eindämmung der COVID-19-Pandemie haben dazu geführt, dass die Lehre an Hochschulen in Deutschland seit dem Sommersemester 2020 häufig nicht in der gewohnten Form von Präsenzveranstaltungen stattfinden konnte. Die Hochschulen haben mittlerweile eine große Bandbreite lokaler Lösungen für die notwendig gewordene Umstellung auf digitale Lehre umgesetzt. Für die weitere Zukunft der universitären Lehre stellen sich Fragen, die sowohl die methodischdidaktische wie insbesondere auch die fachliche Ausgestaltung hybrider Lehrkonzepte berühren: Welche Chancen und Potenziale, aber auch Herausforderungen sind mit zunehmend hybrider Hochschullehre verbunden? Inwieweit können Präsenzveranstaltungen sinnvoll durch digitale Formate, weitere Lernorte und informelle Lernprozesse ergänzt werden? Welche Implikationen lassen sich aus den empirischen Daten für die hybride Hochschullehre in den Fächern und im Lehramt und deren jeweiligen Spezifika ableiten? Gegenstand dieses Hrsg.-Bandes sind Einblicke in digitale, aber auch hybride Lehre, die Anlässe zur Reflexion der Förderung spezifisch fachlicher und/oder lehramtsbezogener Kompetenzentwicklungen bieten.
description: Forschung und Innovation in der Hochschulbildung; 15
title: COLONIC COMPLICATIONS IN PATIENTS WITH ACUTE PANCREATITIS: What you should know as a radiologist
Creators: name: Iturralde-Garriz, Amaya
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Colon
subject: CT
subject: Contrast agent-intravenous
subject: Localisation
subject: Infection
subject: Fistula
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: -To emphasize the importance of colonic complications in acute pancreatitis (frequency and severity). -To specify how to identify these complications in the controls or in the additional tests performed in some patient cases. -To highlight the...
title: Telehealth Acceptance and Commitment Therapy for Adolescents With Transdiagnostic Health-Related Anxiety: A Randomized Controlled Trial
Creators: name: Petersen, Julie M.
Publisher: name: Utah State University
Year: 2023

description: Health-related anxiety is a growing issue to understand how to treat, particularly following the COVID-19 pandemic. Some studies show that a specific type of therapy, acceptance and commitment therapy (ACT), may be beneficial for health anxiety in adults, but this has not yet been tested with adolescents. The present study is a randomized, waitlist-controlled trial of ACT delivered via Zoom for adolescents struggling with health-related anxiety. A total of 30 adolescents (ages 12-17), plus one caretaker each (N = 60), living in Utah and currently struggling with health-related anxiety were enrolled. The majority of caretakers and adolescents were White, non- Hispanic/Latine, and female. Participants in the treatment condition received ten weekly, 50-minute sessions of ACT delivered via Zoom. Overall, adolescents who received ACT reported small, significant decreases in health-related anxiety as compared to the waitlist. No differences were found between groups for adolescent-rated general anxiety, depression, psychological inflexibility, or anxiety sensitivity. Caretakers reported decreases in child general anxiety and improvements in parental psychological inflexibility. No significant differences were found between groups for caretaker-rated familial accommodation and accommodation-related child distress. Overall, adolescents and caretakers rated the treatment positively. Future studies should test ACT with more diverse groups of adolescents as well as compare it to other available therapy options. However, this study is the first to examine ACT as a potential treatment for health-related anxiety in adolescents, and thereby adds to the growing literature supporting the use of ACT as a potential treatment option for youth.
Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger
Creators: name: Glaser, Sally L.
name: Bernstein, Jonine L.
name: Press, Michael F.
name: Thompson, W. Douglas
name: Lynch, Charles F.
name: Gammon, Marilie D.
name: Gaudet, Mia M.
name: Schildkraut, Joellen
name: Haile, Robert W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Differences in incidence, prognosis, and treatment response suggest gene expression patterns may discern breast cancer subtypes with unique risk factor profiles; however, previous results were based predominantly on older women. In this study, we examined similar relationships in women ≤56 years, classified by immunohistochemical staining for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 for 890 breast cancer cases and 3,432 frequency-matched population-based controls. Odds ratios (OR) and 95% confidence intervals (CI) for tumor subtypes were calculated using multivariate polytomous regression models. A total of 455 (51.1%) tumors were considered luminal A, 72 (8.1%) luminal B, 117 (13.1%) non-luminal HER-2/neu+,and 246 (27.6%) triple negative. Triple negative tumors were associated with breast feeding duration (per 6 months: OR = 0.76, 95% CI 0.64–0.90). Among pre-menopausal women, increasing body size was more strongly associated with luminal B (OR = 1.73, 95% CI 1.07–2.77) and triple negative tumors (OR = 1.67, 95% CI 1.22–2.28). A history of benign breast disease was associated only with increased risk of luminal A tumors (OR = 1.89, 95% CI 1.43–2.50). A family history of breast cancer was a risk factor for luminal A tumors (OR = 1.93, 95% CI 1.38–2.70) regardless of age, and triple negative tumors with higher risks for women <45 (OR = 5.02, 95% CI 2.82–8.92; P for age interaction = 0.005). We found that little-to-no breastfeeding and high BMI were associated with increased risk of triple negative breast cancer. That some risk factors differ by molecular subtypes suggests etiologic heterogeneity in breast carcinogenesis among young women.
title: River Response to Sediment Supply: The Sand Bed Case
Creators: name: Leonard, Christina M.
Publisher: name: Utah State University
Year: 2022

description: Effective management of in-channel and floodplain habitat requires an ability to forecast river response to changes in water and sediment supply. These changes may result from dam construction/decommissioning, changes in reservoir operations, or changes in grazing or forestry practices. If a change in water and sediment supply causes sediment to be delivered faster than the channel’s capacity to transport it, sediment will accumulate in the reach, leading to changes in channel form and increasing the potential for flooding. A decrease in sediment supply relative to transport capacity can lead to channel incision. The extent and timing of sediment accumulation or evacuation can be moderated, even reversed, by poorly understood changes in the river bed grain size. This dissertation explores the joint response of river bed texture and sediment storage in order to better predict the magnitude of channel change in response to upstream changes in infrastructure or land use in sand bed rivers. We use a combination of field measurements of sediment transport, analysis of channel change from repeat aerial images, and numerical modeling to explore the interaction among sediment supply rate and grain size with bed grain size and morphologic adjustment. We find that sand sizes are sorted throughout the alluvial channel and floodplain such that the in-channel response may be different than floodplain adjustments. At our field site, certain sand sizes evacuate as the bed coarsened while other sand sizes accumulated in the floodplains. These findings indicate that conditions of sediment accumulation or evacuation cannot reveal important changes in the river and size fractional sediment budgets are needed to evaluate channel change. Our numerical modeling indicates that the supply grain size has a strong effect on the grain size of sand on the bed, making the river more or less effective at transporting sediment. Under conditions when the sediment supply increases, such as after wildfires, dam removals, or changes in land use or forestry practices, small changes in the grain size of sand on the channel bed can cause sediment to accumulate, evacuate, or there may be no morphologic adjustment depending on the length of the disturbance and how the supply grain size changes. This has important implications for forecasting downstream impacts. Management concerns may be delayed or even eliminated depending on the bed grain size response. These findings demonstrate the importance of considering the supply grain size and behavior and destination of the fractional sizes in transport when predicting a sand-bed river response to a watershed disturbance.
Finite volume corrections to the binding energy of the X(3872)
Creators: name: Jansen, M.
name: Hammer, H. -W.
name: Jia, Yu
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The quark mass dependence of hadrons is an important input for lattice calculations. We investigate the light quark mass dependence of the binding energy of the X(3872) in a finite box to next-to-leading order in an effective field theory for the X(3872) with perturbative pions (XEFT). At this order, the quark mass dependence is determined by a quark mass-dependent contact interaction in addition to the one-pion exchange. While there is only a moderate sensitivity to the light quark masses in the region up to twice their physical value, the finite volume effects are significant already at box length as large as 20 fm.
description: 23 pages, 9 figures, REVTeX
French translation of: Plain language summary of results from the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer.
Creators: name: Powles, Thomas
name: Hoon Park, Se
name: Voog, Eric
name: Caserta, Claudia
name: Valderrama, Begoña P.
name: Gurney, Howard
name: Kalofonos, Haralabos
name: Radulovic, Sinisa
name: Demey, Wim
name: Ullén, Anders
name: Loriot, Yohann
name: Sridhar, Srikala S.
name: Tsuchiya, Norihiko
name: Kopyltsov, Evgeny
name: Sternberg, Cora N.
name: Bellmunt, Joaquim
name: Aragon-Ching, Jeanny B.
name: Petrylak, Daniel P.
name: Laliberte, Robert J.
name: Huang, Bo
name: Costa, Nuno
name: Blake-Haskins, John A.
name: Grivas, Petros
Publisher: name: Future Science Group
Year: 2023
Subjects: Cancer therapy (excl. chemotherapy and radiation therapy)

description: French Translation
title: Study of Neutrino and Antineutrino Oscillations in the Three-Flavour PMNS Paradigm at the T2K Experiment: Determination of the CP-Violating Phase and the Search for Muon Antineutrino to Electron Antineutrino Oscillations
Creators: name: Bench, Francis
Publisher: name: University of Liverpool Repository
Year: 2022

description: T2K (Tokai to Kamioka) is an accelerator-based long-baseline neutrino oscillation experiment that aims to study the parameters which govern these oscillations. An almost pure muon neutrino or muon antineutrino beam with flux sharply peaked at a neutrino energy of 0.6 GeV is produced at the J-PARC facility in Japan before passing through a suite of near detectors then travelling 295 km through the Earth’s crust to the 50 ktonne water Cherenkov far detector, Super-Kamiokande. The near detectors, located 280 m from the beam production target, measure the unoscillated flavour composition of the beam and constrain the flux and neutrino-nucleus interaction models. Together, the near and far detectors measure the change in flavour composition, therefore allowing the oscillation parameters to be determined. This thesis presents a simultaneous analysis of observations from five Super-Kamiokande event samples, selected to measure the disappearance of muon neutrinos/antineutrinos and the appearance of electron neutrinos/antineutrinos. Working in the three active neutrino flavour paradigm and using the PMNS parameterisation, constraints are obtained on the oscillation parameters δCP, sin²(θ₂₃), Δm²₃₂, and sin²(θ₁₃) in both mass orderings. Additionally, the muon antineutrino to electron antineutrino oscillation channel was specifically analysed in order to determine whether such events could be fully distinguished from the expected backgrounds and it was found that the background-only hypothesis was disfavoured at a significance of 2.4σ. For all fits to the oscillation parameters, the best-fit was found to be in the normal mass ordering and the corresponding best-fit points and ±1σ ranges are as follows, where the global best-fit measurement on sin²(2θ₁₃) from reactor antineutrino experiments was used as a constraint except when producing the T2K constraint on sin²(θ₁₃). δCP = -2.01 (+0.93 / -0.76) sin²(θ₂₃) = 0.552 (+0.024 / -0.048) Δm²₃₂ = (2.49 ± 0.05) × 10¯³ eV²c⁻⁴ sin²(θ₁₃) = 2.54 (+0.49 / -0.38) × 10¯² For δCP, the best-fit point is close to the maximally CP-violating value of -π/2, and CP-conservation is excluded at close to the 90% confidence level. The observed constraint on δCP is stronger than expected from sensitivity studies, but was found to be compatible with the three-flavour oscillation model. The T2K constraints on Δm²₃₂ and sin²(θ₁₃) are competitive with recent measurements from other experiments, and are world-leading for sin²(θ₂₃) and δCP.
A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab
Creators: name: Wheatley, Duncan
name: Winer, Eric P.
name: Hickish, Tamas
name: Garcia, Agustin A.
name: Vinisko, Richard
name: Munster, Pamela
name: Mendelson, David
name: Uttenreuther-Fischer, Martina
name: Wind, Sven
name: Frakes, Laurie
name: Houston, Stephen
name: Kelly, Steve
name: Lin, Nancy U.
name: Jones, Hilary
name: Carey, Lisa A.
name: Cleator, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Afatinib is an oral, ErbB family blocker, which covalently binds and irreversibly blocks all kinase-competent ErbB family members. This phase II, open-label, single-arm study explored afatinib activity in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients progressing after trastuzumab treatment. Patients had stage IIIB/IV HER2-positive metastatic breast cancer, with progression following trastuzumab or trastuzumab intolerance and an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2. Patients received 50mg afatinib once-daily until disease progression. Primary endpoint was objective response rate (Response Evaluation Criteria in Solid Tumors 1.0), with tumor assessments every 8weeks. Forty-one patients were treated. Patients had received a median of three prior chemotherapy lines (range, 0–15) and 68.3% had received trastuzumab for >1year. Four patients (10% of 41 treated; 11% of evaluable patients) had partial response. Fifteen patients (37% of 41) had stable disease as best response and 19 (46% of 41) achieved clinical benefit. Median progression-free survival was 15.1weeks (95% confidence interval [CI]: 8.1–16.7); median overall survival was 61.0weeks (95% CI: 56.7–not evaluable). Most frequent common terminology criteria for adverse events grade 3 treatment-related adverse events were diarrhea (24.4%) and rash (9.8%). Afatinib monotherapy was associated with promising clinical activity in extensively pretreated HER2-positive breast cancer patients who had progressed following trastuzumab treatment.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-012-2003-y) contains supplementary material, which is available to authorized users.
MPEC 2024-R211 : 2024 RH9
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RH9

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival
Creators: name: Nobel, Andrew
name: Nwachukwu, Chika
name: Weigman, Victor J.
name: He, Xiaping
name: Nordgard, Silje H.
name: Shabalin, Andrey A.
name: Perou, Charles M.
name: Huo, Dezheng
name: Grushko, Tatyana
name: Børresen-Dale, Anne Lise
name: Kristensen, Vessela N.
name: Parker, Joel S.
name: Chao, Hann Hsiang
name: Olopade, Olufunmilayo I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Breast cancer is a heterogeneous disease with known expression-defined tumor subtypes. DNA copy number studies have suggested that tumors within gene expression subtypes share similar DNA Copy number aberrations (CNA) and that CNA can be used to further sub-divide expression classes. To gain further insights into the etiologies of the intrinsic subtypes, we classified tumors according to gene expression subtype and next identified subtype-associated CNA using a novel method called SWITCHdna, using a training set of 180 tumors and a validation set of 359 tumors. Fisher’s exact tests, Chi-square approximations, and Wilcoxon rank-sum tests were performed to evaluate differences in CNA by subtype. To assess the functional significance of loss of a specific chromosomal region, individual genes were knocked down by shRNA and drug sensitivity, and DNA repair foci assays performed. Most tumor subtypes exhibited specific CNA. The Basal-like subtype was the most distinct with common losses of the regions containing RB1, BRCA1, INPP4B, and the greatest overall genomic instability. One Basal-like subtype-associated CNA was loss of 5q11–35, which contains at least three genes important for BRCA1-dependent DNA repair (RAD17, RAD50, and RAP80); these genes were predominantly lost as a pair, or all three simultaneously. Loss of two or three of these genes was associated with significantly increased genomic instability and poor patient survival. RNAi knockdown of RAD17, or RAD17/RAD50, in immortalized human mammary epithelial cell lines caused increased sensitivity to a PARP inhibitor and carboplatin, and inhibited BRCA1 foci formation in response to DNA damage. These data suggest a possible genetic cause for genomic instability in Basal-like breast cancers and a biological rationale for the use of DNA repair inhibitor related therapeutics in this breast cancer subtype.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-011-1846-y) contains supplementary material, which is available to authorized users.
Weak Gravitational Lensing of quantum perturbed Lukewarm Black Holes and cosmological constant effect
Creators: name: Ghaffarnejad, H.
name: Mojahedi, M. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: Aim of the paper is study weak gravitational lensing of quantum (perturbed) (QLBHL) and classical (CLBHL) Lukewarm black hole in presence of cosmological parameter $Λ$. We apply numerical method to evaluate deflection angle of bending light rays, images locations $θ$ of sample source $β=-\fracπ{4},$ and corresponding magnifications $μ.$ There is not obtained real values for Einstein rings locations $θ_E(β=0)$ for CLBHL but we calculate them for QLBHL. As experimental test of our calculations, we choose mass $M$ of 60 type of most massive observed galactic black holes as gravitational lens and study quantum matter fields effects on the angle of bending light rays in presence of the cosmological constant effects. We calculate locations of non-relativistic images and corresponding magnifications. Numerical diagrams show that the quantum matter effects cause to be reduce absolute values of the quantum deflection angle with respect to the classical ones. Sign of the quantum deflection angle is changed with respect to the classical values in presence of the cosmological constant. This means dominance of anti-gravity counterpart of the cosmological horizon on the bending light rays angle with respect to absorbing effects of local 60 type of observed most massive black holes. Variations of the image positions and magnifications are negligible by increasing dimensionless cosmological constant $ε=\frac{16ΛM^2}{3}.$ Deflection angle takes positive (negative) values for CLBHL (QLBHL) and they decrease very fast (slow) by increasing closest distance $x_0$ of bending light ray and/or dimensionless cosmological parameter for sample giant black holes $0.001
description: 38 pages, 5 figures, 14 tables, accepted as Poster presentation: 11th Int. LISA Symposium, 5 to 9 Sep 2016, Zurich, Switzerland
Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)
Creators: name: Dressler, Lynn
name: Van't Veer, Laura J.
name: Berry, Donald A.
name: Davis, Sarah E.
name: Chhieng, David
name: Mies, Carolyn
name: Livasy, Chad
name: Rugo, Hope S.
name: Singh, Baljit
name: Carpenter, John T.
name: Hudis, Clifford
name: Giri, Dilip
name: Krontiras, Helen
name: Cheang, Maggie C.U.
name: Wolf, Denise
name: Hylton, Nola
name: Yau, Christina
name: Tripathy, Debu
name: Lehman, Constance
name: Montgomery, Leslie
name: Conway-Dorsey, Kathleen
name: Perou, Charles M.
name: Chin, Koei
name: Gray, Joe W.
name: Liu, Minetta C.
name: Carey, Lisa
name: Olopade, Olufunmilayo I.
name: Lenburg, Marc E.
name: Buxton, Meredith B.
name: Chen, Yunni Yi
name: De Michele, Angela
name: Au, Alfred
name: Rabban, Joseph
name: Esserman, Laura J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Neoadjuvant chemotherapy for breast cancer allows individual tumor response to be assessed depending on molecular subtype, and to judge the impact of response to therapy on recurrence-free survival (RFS). The multicenter I-SPY 1 TRIAL evaluated patients with ≥3cm tumors by using early imaging and molecular signatures, with outcomes of pathologic complete response (pCR) and RFS. The current analysis was performed using data from patients who had molecular profiles and did not receive trastuzumab. The various molecular classifiers tested were highly correlated. Categorization of breast cancer by molecular signatures enhanced the ability of pCR to predict improvement in RFS compared to the population as a whole. In multivariate analysis, the molecular signatures that added to the ability of HR and HER2 receptors, clinical stage, and pCR in predicting RFS included 70-gene signature, wound healing signature, p53 mutation signature, and PAM50 risk of recurrence. The low risk signatures were associated with significantly better prognosis, and also identified additional patients with a good prognosis within the no pCR group, primarily in the hormone receptor positive, HER-2 negative subgroup. The I-SPY 1 population is enriched for tumors with a poor prognosis but is still heterogeneous in terms of rates of pCR and RFS. The ability of pCR to predict RFS is better by subset than it is for the whole group. Molecular markers improve prediction of RFS by identifying additional patients with excellent prognosis within the no pCR group.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-011-1895-2) contains supplementary material, which is available to authorized users.
Barjols, place de la Rouguière, vue d'ensemble avec le public, le foyer, le tourne-broche et le boeuf
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel
Creators: name: Carey, Lisa A.
name: Winham, Stacey J.
name: McLeod, Howard L.
name: Dees, E. Claire
name: Drobish, Amy
name: Hertz, Daniel L.
name: Motsinger-Reif, Alison A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Paclitaxel is one of the most frequently used chemotherapeutic agents for the treatment of breast cancer patients. Using a candidate gene approach, we hypothesized that polymorphisms in genes relevant to the metabolism and transport of paclitaxel are associated with treatment efficacy and toxicity. Patient and tumor characteristics and treatment outcomes were collected prospectively for breast cancer patients treated with paclitaxel-containing regimens in the neoadjuvant setting. Treatment response was measured before and after each phase of treatment by clinical tumor measurement and categorized according to RECIST criteria, while toxicity data were collected from physician notes. The primary endpoint was achievement of clinical complete response (cCR) and secondary endpoints included clinical response rate (complete response + partial response) and grade 3+ peripheral neuropathy. The genotypes and haplotypes assessed were CYP1B1*3, CYP2C8*3, CYP3A4*1B/CYP3A5*3C, and ABCB1*2. A total of 111 patients were included in this study. Overall, cCR was 30.1 % to the paclitaxel component. CYP2C8*3 carriers (23/111, 20.7 %) had higher rates of cCR (55 % vs. 23 %; OR = 3.92 [95 % CI: 1.46–10.48], corrected p = 0.046). In the secondary toxicity analysis, we observed a trend toward greater risk of severe neuropathy (22 % vs. 8 %; OR = 3.13 [95 % CI: 0.89–11.01], uncorrected p = 0.075) in subjects carrying the CYP2C8*3 variant. Other polymorphisms interrogated were not significantly associated with response or toxicity. Patients carrying CYP2C8*3 are more likely to achieve clinical complete response from neoadjuvant paclitaxel treatment, but may also be at increased risk of experiencing severe peripheral neurotoxicity.
Genetic polymorphisms in telomere pathway genes, telomere length, and breast cancer survival
Creators: name: Bradshaw, Patrick T.
name: Wang, Qiao
name: Santella, Regina M.
name: Terry, Mary Beth
name: Shen, Jing
name: Neugut, Alfred I.
name: Teitelbaum, Susan L.
name: Gammon, Marilie D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The impact of genetic variants in telomere pathway genes on telomere length and breast cancer survival remains unclear. We hypothesized that telomere length and genetic variants of telomere pathway genes are associated with survival among breast cancer patients. A population-based cohort study of 1,026 women diagnosed with a first primary breast cancer was conducted to examine telomere length and 52 genetic variants of 9 telomere pathway genes. Adjusted Cox regression analysis was employed to examine associations between telomere length, genetic variants and all-cause and breast cancer-specific mortality. Longer telomere length was significantly correlated with all-cause mortality in the subgroup with HER-2/neu negative tumors (HR=1.90, 95%CI: 1.12–3.22). Carrying the PINX1-33 (rs2277130) G-allele was significantly associated with increased all-cause mortality (HR=1.45, 95% CI: 1.06–1.98). Three SNPs (TERF2-03 rs35439397, TERT-14 rs2853677 and TERT-67 rs2853669) were significantly associated with reduced all-cause mortality. A similar reduced trend for breast cancer-specific mortality was observed for carrying the TERT-14 (rs2853677) T-allele (HR=0.57, 95% CI: 0.39–0.84), while carrying the POT1-18 (rs1034794) T-allele significantly increased breast cancer specific-mortality (HR=1.48, 95% CI: 1.00–2.19). However, none of the associations remained significant after correction for multiple tests. A significant dose-response effect was observed with increased number of unfavorable alleles/genotypes (PINX1-33 G-allele, POT1-18 T-allele, TERF2-03 GG, TERT-14 CC, and TERT-67 TT genotypes) and decreased survival. These data suggest that unfavorable genetic variants in telomere pathway genes may help to predict breast cancer survival.
title: Confidence and College Applications: Evidence from a Randomized Intervention
Creators: name: Hakimov, Rustamdjan
name: Schmacker, Renke
name: Terrier, Camille
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2023

description: This paper investigates the role self-confidence plays in college applications. Using incentivized experiments, we measure the self-confidence of more than 2,000 students applying to colleges in France. This data reveals that the best female and low-SES students significantly underestimate their rank in the grade distribution compared to male and high-SES students. By matching our survey data with administrative data on real college applications and admissions, we show that miscalibrated confidence affects college choice on top of grades. We then estimate the impact of a randomized intervention that corrects students' under- and overconfidence by informing them of their real rank in the grade distribution. The treatment reduces the impact of under- and overconfidence for college applications, to the point where only grades but not miscalibrated confidence predict the application behavior of treated students. Providing feedback also makes the best students, who were initially underconfident, apply to more ambitious programs with stronger effects for female and low-SES students.
EFT for Vortices with Dilaton-dependent Localized Flux
Creators: name: Burgess, C. P.
name: Diener, Ross
name: Williams, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study how codimension-two objects like vortices back-react gravitationally with their environment in theories (such as 4D or higher-dimensional supergravity) where the bulk is described by a dilaton-Maxwell-Einstein system. We do so both in the full theory, for which the vortex is an explicit classical `fat brane' solution, and in the effective theory of `point branes' appropriate when the vortices are much smaller than the scales of interest for their back-reaction (such as the transverse Kaluza-Klein scale). We extend the standard Nambu-Goto description to include the physics of flux-localization wherein the ambient flux of the external Maxwell field becomes partially localized to the vortex, generalizing the results of a companion paper to include dilaton-dependence for the tension and localized flux. In the effective theory, such flux-localization is described by the next-to-leading effective interaction, and the boundary conditions to which it gives rise are known to play an important role in how (and whether) the vortex causes supersymmetry to break in the bulk. We track how both tension and localized flux determine the curvature of the space-filling dimensions. Our calculations provide the tools required for computing how scale-breaking vortex interactions can stabilize the extra-dimensional size by lifting the dilaton's flat direction. For small vortices we derive a simple relation between the near-vortex boundary conditions of bulk fields as a function of the tension and localized flux in the vortex action that provides the most efficient means for calculating how physical vortices mutually interact without requiring a complete construction of their internal structure. In passing we show why a common procedure for doing so using a $δ$-function can lead to incorrect results. Our procedures generalize straightforwardly to general co-dimension objects.
description: 45 pages + appendix, 6 figures
title: Montpelier, Idaho's Locomotive Firemen and Enginemen: A Community of Railroaders, 1900-1920
Creators: name: Fife, Kimball M.
Publisher: name: Utah State University
Year: 1993

description: Research for this thesis drew from the records of the Brotherhood of Locomotive Firemen, Re-Echo Lodge #195 of Montpelier, Idaho; the U.S. Censuses for the years 1900, 1910, and 1920; and the Montpelier Examiner, 1900-1920. The study focused on the world of railroad firemen and enginemen from the standpoint of the firemen's union members. A special focus examined the locomotive firemen's experiences of working in a predominantly Mormon settlement and the diversity that the railroaders brought to Montpelier.
Locomotive firemen and enginemen who were union members relied on their solidarity as a body of organized labor for protection of life and livelihood. The union provided stability to its members who labored in an uncertain and dangerous line of work. Locomotive firemen and enginemen emerged as a distinct class of involved workers in a society economically and socially impacted by the railroad. The Brotherhood of Locomotive Firemen in Montpelier, Idaho proved to be a valuable constituent of the railroad community specifically and Montpelier generally.
ジャズ音楽のピアノ演奏における発音時刻の可視化システムの提案
Creators: name: 森田果歩
Publisher: name: Zenodo
Year: 2023
Subjects: ジャズ
発音タイミング
可視化

description: ジャズにはスウィングといわれるリズムで演奏するなど,必ずしも楽譜上のジャストなタイミングで演奏されないことが多い.しかし,演奏者や曲によって発音のタイミングをどの程度ずらすかは様々である. これまでジャズを対象とした発音タイミングの分析が行われてきた.これらの研究では,8分音符のずれに着目したものが多数あったが,重要な特徴はこれだけではない.ジャズミュージシャンは8分音符だけを演奏するわけではなく,16分音符の発音のタイミングをずらすこともある.そのため,発音タイミングの全体を可視化することが有効であると考えられる. 本研究では,ジャズのピアノ演奏のオーディオを対象とし,既存の発音時刻検出技術やビート解析技術を使って発音時刻とビート時刻を検出し,発音タイミング全体を可視化する方法を提案する. 8つの演奏を可視化した図を比較した結果,演奏間の類似点,相違点を読み取ることができた.具体的には,すべてのテータムにおいて鋭いピークが読み取れる演奏があったことから16分音符での発音のずれが読み取れることがわかった.一方で,鋭いピークが読み取れない演奏があった.これは,様々な要因が考えられるが,そのうちの一つとしてテンポが遅いことが共通しており,発音時刻の検出が細かすぎたため本研究の可視化の提案手法では読み取れなかったと考えられる.しかし,発音時刻,ビート時刻の検出は自動であり,正確な検出ができるわけではない.加えて,可視化結果が本来のジャズの演奏の特徴を見いだせているかの疑問が残っている.今後は,可視化結果の妥当性を実際の演奏を聴いてもらいながら専門家から評価を得ることで検証するとともに,妥当であった場合,より多様な楽曲に対して可視化を試みていきたい.