cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Determining whether trait-level character strengths predict engagement in a digital mental health intervention
Creators: name: Mangelsdorf, Shaminka N.
name: Smith, Alicia
name: Alvarez-Jimenez, Mario
name: Hitchcock, Caitlin
name: Cross, Shane
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Health Information Technology
subject: Translational Medical Research
subject: Medicine and Health Sciences
subject: Psychiatry and Psychology

description: Mental illness is a leading cause of disability worldwide and 75% of problems emerge prior to the age of 25. Despite the high prevalence and pressures on mental health services, access to support has not improved. MOST (Moderated Online Social Therapy) is an award winning, world leading digital intervention that provides evidence-based psychological treatment. Using the platform, young people (12-25) are able to access professional psychological, vocational, and social support. The digital mental health intervention provides individuals with immediate access to evidence-based care, and facilitates rapid detection and response to risk or relapse between sessions. Although digital interventions have been associated with improved outcomes, there is substantial user drop out and discontinuation of program engagement. To address this issue, here we will use statistical modelling techniques to identify groups of users based on character strengths recorded at intake, and assess their patterns of engagement with MOST. Engagement measures include platform use, therapeutic content use, social network use and interaction with the moderation team. We hypothesise that trait level characteristics will (1) predict the length of engagement with MOST, (2) predict different patterns of engagement with the platform, and (3) predict improvement in symptoms as a degree of engagement. This study will enable us to determine at intake which users may need additional support, and in what areas, to stay engaged with the program.
Caracterização de ácaros trombiculídeos em cães e gatos de Portugal e pesquisa de potenciais agentes zoonóticos
Creators: name: Marques, Cátia
name: Diogo, Inês
name: Cruz, João T
name: Costa, Pedro
name: Munhoz, Ana Maria
name: Waap, Helena
name: Pereira, André
name: Ramilo, David W.
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: Os ácaros trombiculídeos são ectoparasitas com potencial zoonótico, responsáveis por sinais clínicos dermatológicos e neurológicos em cães, gatos e humanos. Para além do seu potencial zoonótico, os trombiculídeos podem ser vetores de vários agentes patogénicos, tratando-se de um problema de saúde pública. Os Médicos Veterinários geralmente não detetam a presença destes parasitas nos animais domésticos e, quando os detetam, assumem-nos empiricamente como sendo da espécie Neotrombicula autumnalis, o que, por vezes, não corresponde à realidade. Como a sua distribuição em Portugal não está completamente estudada e tratando-se de uma parasitose negligenciada, o nosso projeto de investigação tem como objetivo a recolha e identificação destes ácaros em animais com tutor e errantes e no meio ambiente em várias regiões do nosso país, assim como detetar a presença de agentes patogénicos através de técnicas de biologia molecular. Sendo um tema que abrange as áreas científicas de Parasitologia, Doenças Parasitárias, Doenças Infecciosas e Biologia Molecular, este trabalho pode fornecer dados relevantes para a elaboração de até duas dissertações de Mestrado Integrado em Medicina Veterinária. Palavras-chave: Ácaro, Trombiculídeo, Zoonose, Agentes patogénicos. Financiamento: Projetos de investigação da Faculdade de Medicina Veterinária, Universidade Lusófona, 2021 - Trombiculidae.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
Infeção por Crenosoma striatum e Brachylaemus erinacei num exemplar de Ouriço europeu (Erinaceus europaeus) – Case report.
Creators: name: Godinho, Guilherme
name: Nunes, Carolina
name: Lopes, Carolina
name: Gonçalves, Andreia
name: Munoz, Ana Maria
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: Objetivos: Este estudo teve como objetivo realizar o diagnóstico copropasitológico de fezes de um ouriço juvenil, macho, oriundo da zona de Sines e internado no CRASSA para reabilitação. Materiais e métodos: Foram realizadas duas técnicas coproparasitológicas (Willis e Baermann) para observação de ovos de helmintes e de larvas (L1) de nematodes pulmonares. Em primeiro lugar foi analisado pelo método de Willis uma amostra de fezes fresca. Posteriormente foram recolhidas quatro amostras de fezes frescas em dias consecutivos; estas foram divididas ao meio e analisadas pelo método de Willis com solução saturada de açúcar e a outra metade pelo método de Baermann para pesquisa de larvas pulmonares. Resultados: Nos resultados coprológicos observou-se grande número de ovos de Brachylaemus erinacei, tendo sido proposto o tratamento com praziquantel (10 mg/kg PO). Após 30 dias realizou-se uma segunda análise corológica onde foram observados ovos de B. erinacei inviáveis e a presença de larvas de C. striatum pela técnica de Baermann. Foi administrado um novo tratamento com imidacloprida (10 mg/kg) + moxidectina (1 mg/kg) (spot on). Na análise coprológica realizada 2 dias depois foi possível observar larvas mortas de C. striatum. Para a confirmação da eficácia do tratamento foram realizados novos exames coprológicos uma semana depois, cujos resultados foram negativos. Conclusões:Comprovou-se a necessidade da realização de exames coprológicos para a escolha do tratamento apropriado, devendo verificar-se a eficácia do mesmo através de exames coprológicos. Os anti-helmínticos não são eficazes no tratamento de todas as parasitoses, sendo que o seu uso indiscriminado pode levar ao aparecimento de resistências. Palavras-chave: Crenosoma striatum, Brachylaemus erinacei, Ouriço europeu.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
A Ciência Aberta é possível com dados clínicos? Ferramentas para planeamento e avaliação de risco
Creators: name: Rodrigues, Joana
name: Sales, Célia
name: Matos, Paula Mena
name: Castro, João
name: Ribeiro, Cristina
Publisher: name: Zenodo
Year: 2020

description: Communication presented at the Research Data Management Forum, Instituto Politécnico de Castelo Branco, Castelo Branco, Portugal. [In Portuguese]
Functional characterization of neural circuits responsible for goal-directed behaviors in the healthy and Autistic brain
Creators: name: Remondes, Miguel
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: The ability of selecting actions based on desired goals, according to knowledge stored previously in memory, is essential for survival. However, we must also be ready to adapt such behaviour to unexpected changes in context, often contrary to what would be supported by previous knowledge. Consistently, medical literature, fMRI, and electrophysiology studies, suggest a dialogue between the medial temporal structures entorhinal cortex (EC) and hippocampus (HIPP), and medial mesocortical (MMC) cingulate (CG) and retrosplenial (RSC) cortices in forming an enduring internal representation of existing context (contextual memory) in HIPP, made available to executive CG regions responsible for behavioral control and action planning. The mechanisms behind these operations remain unknown, but available data strongly suggests that they rely on the synaptic connectivity associating the HIPP-EC with RSC-CG structures1. On the other hand, such neural circuit is a frequent target of dysfunction in common neuropsychiatric conditions, namely Autism Spectrum Disorders (ASD), leading us to hypothesize that a malfunctioning cortico-thalamic-hippocampal circuit disrupts the translation of percepts between ego and allocentric reference frames, hindering behaviors directed at the outside world. To dissect the mechanisms behind adaptive goal-directed behavior and dysfunctions thereof, we record and manipulate neural activity in rodents trained to perform GDB tasks in mazes using mild food deprivation as a motivation factor. While rats perform goal-directed choices contingent on context we use, a) in vivo electrophysiology with 32-independently movable tetrodes targeting relevant brain areas, b) genetically-encoded neural actuators (Optogenetics and Chemogenetics) expressed in specific neuronal populations, c) behavioral protocols using distinct contextual manipulations, d) all managed by a single open-source software. This setup grants us the possibility of simultaneously interacting with the animal’s behavior and with the brain physiology in real-time gives us unprecedent control over the animal, the environment, and neural circuits. By applying our experimental paradigm to VPA-ASD rodents we will characterize circuit malfunctions underlying behavioral deficits therein present, use pharmacology and optogenetics to revert such malfunctions, and test whether we can entrain native oscillatory and plasticity mechanisms to achieve a permanent reversal of ASD symptoms. We realize the potential of leveraging our discoveries to inform future therapeutic strategies, something we will capitalize on by reaching out to groups involved in medical research, and explore possible applications of our research developments.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
Individual Characteristics and Physical Activity in Older Adults: A Systematic Review
Creators: name: Notthoff, Nanna
name: Reisch, Peter
name: Gerstorf, Denis
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: Aging
subject: Individual characteristics
subject: Demographics
subject: Self-efficacy
subject: Motivation
subject: Locus of control
subject: Health
subject: Physical activity
subject: 610 Medizin und Gesundheit

description: Background: People aged 50 years and older are regularly identified as the most sedentary group in the population. However, even within this group, there are considerable interindividual variations in physical activity (PA) levels. They have been the subject of many studies. Based on single studies, no clear picture as to which characteristics are important has emerged. Objective: The goal of our contribution was to identify which individual characteristics are consistently linked to high PA levels in older adults. Methods: We conducted a systematic review of the literature considering demographic characteristics (gender, education, marital status, employment), health (subjective, health problems), and psychological factors (motivation, self-efficacy, locus of control). A systematic search of abstracts in the database Web of Science and a thorough screening process according to a priori specified criteria yielded 63 studies for inclusion in this review. Results: Two psychological factors - motivation and self-efficacy - and the perception of one's health seem to be consistently linked to higher PA levels in older adults. Selected demographic variables - gender and education - may be important for some types of PA. Conclusion: Our review suggests that differentiation of PA by domains is important for identifying and understanding which individual characteristics are associated with PA levels and how. Pinpointing what reliably distinguishes older adults who are active from those who are not is essential for designing effective interventions to promote PA in later life.
Authoritative Parenting and Self Esteem
Creators: name: Miller, Jessica
name: Zizhong Xiao
name: Sheisa Naderi
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: causal variable
subject: observational research
subject: outcome variable

description: Using authoritative parenting is known to raise well adjusted and socially successful individuals. This poses the question, what is the effect that being raised with an authoritative parenting style has on self esteem?
Fermentative Cyclohexane Carboxylate Formation in Syntrophus aciditrophicus
Creators: name: Boll, Matthias
name: Kung, Johannes W.
name: Ermler, Ulrich
name: Martins, Berta
name: Buckel, Wolfgang
Publisher: name: Humboldt-Universität zu Berlin
Year: 2016
Subjects: subject: Fermentation
subject: Syntrophus aciditrophicus
subject: Cyclohexane carboxylate
subject: 570 Biologie

description: Short-chain fatty acids such as acetic, propionic, butyric or lactic acids are typical primary fermentation products in the anaerobic feeding chain. Fifteen years ago, a novel fermentation type was discovered in the obligately anaerobic Deltaproteobacterium Syntrophus aciditrophicus. During fermentative growth with crotonate and/or benzoate, acetate is formed in the oxidative branch and cyclohexane carboxylate in the reductive branch. In both cases cyclohexa-1,5-diene-1-carboxyl-CoA (Ch1,5CoA) is a central intermediate that is either formed by a class II benzoyl-CoA reductase (fermentation of benzoate) or by reverse reactions of the benzoyl-CoA degradation pathway (fermentation of crotonate). Here, we summarize the current knowledge of the enzymology involved in fermentations yielding cyclohexane carboxylate as an excreted product. The characteristic enzymes involved are two acyl-CoA dehydrogenases specifically acting on Ch1,5CoA and cyclohex-1-ene-1-carboxyl-CoA. Both enzymes are also employed during the syntrophic growth of S. aciditrophicus with cyclohexane carboxylate as the carbon source in coculture with a methanogen. An investigation of anabolic pathways in S. aciditrophicus revealed a rather unusual pathway for glutamate synthesis involving a Re-citrate synthase. Future work has to address the unresolved question concerning which components are involved in reoxidation of the NADH formed in the oxidative branch of the unique cyclohexane carboxylate fermentation pathway in S. aciditrophicus.
Current Pharmacy Curriculum Faculty Process for Reviewing and Utilizing Course Evaluation Comments
Creators: name: Wilcox, Brandyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Objective: To assess faculty utilization and perceptions of course evaluation comments from students. Methods: Course faculty from the UNC Eshelman School of Pharmacy were recruited via email to participate in a 30-minute interview session. Previous course evaluation comments were adapted to create a deidentified mock evaluation. Six interviews were conducted via Zoom, consisting of a think aloud protocol based on the mock course evaluation followed by a cognitive interview focused on goals and current utilization of comments, and common patterns and issues sought by faculty. Interview transcripts were manually cleaned and deidentified. Transcripts were inductively coded by one researcher using MAXQDA. Results: Three overarching themes were identified: general faculty process for reviewing comments (ie, how faculty perceive and analyze comments), comments utilization for course change (ie, how faculty utilize comments in making course changes), and faculty search process (ie, faculty approach to locating common patterns in evaluation comments). The most common subthemes included usefulness of comments, methods for tracking of comment patterns, and challenges with the large quantity of comments each semester. Conclusions: Faculty provided useful insight and feedback regarding the current state of the course evaluation process that can be used to improve the structure, organization, and utilization of course evaluations by faculty. These findings could inform the creation of the course evaluation comment automated analysis program in the next stage of an ongoing project.
Dinâmica de transmissão de Clostridioides difficile – exemplos de abordagens One Health
Creators: name: Nunes, Alexandra
name: Gomes, João Paulo
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: A bactéria Clostridioides difficile tem um impacto importante em termos de saúde animal e humana e o seu isolamento em fezes de animais da cadeia alimentar, itens alimentares e em amostras ambientais levantam questões quanto à sua dinâmica de transmissão. Diversos estudos têm ainda realçado um possível papel dos animais de companhia na transmissão comunitária de estirpes toxigénicas de C. difficile em humanos. Neste contexto, o INSA, em colaboração com a FMV-ULHT, tem vindo a desenvolver alguns estudos para tentar perceber a prevalência e a dinâmica de transmissão deste patogénio. Esta apresentação abordará dois pequenos estudos, um numa suinicultura e outro envolvendo animais de companhia (cães e gatos). O 1º estudo sustenta a possibilidade de transmissão entre animais e reservatórios ambientais, tendo-se ainda identificado, pela 1ª vez a nível mundial, um novo clone produtor de toxinas (RT033), cujas características genéticas contribuem para a manutenção do ciclo de transmissão e com potenciais implicações para a saúde pública. Já no 2º estudo, apesar da diversidade de tipos toxigénicos encontrada, C. difficile do ribotipo RT106 foi o mais prevalente em animais de companhia. Alguns isolados animais deste ribotipo mostraram-se geneticamente próximos a isolados humanos, explicando o recente aumento observado deste ribotipo em infeções humanas no panorama comunitário. Considerando que muitos destes animais são assintomáticos e transportam marcadores de resistência a antimicrobianos, estes reservatórios animais podem constituir um risco adicional para a saúde pública. No geral, estes 2 estudos reforçam a importância de uma vigilância contínua e global no âmbito do conceito One Health. Palavras-chave: Clostridioides difficile, Animais de companhia, Transmissão ambiental-animal-humana, One Health.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
MAICO - Music AI Comparison
Creators: name: Rau, Simeon
name: Sedlmair, Michael
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Music
subject: Musicology
subject: Physical Sciences and Mathematics
subject: Computer Sciences
subject: Arts and Humanities
subject: Graphics and Human Computer Interfaces
subject: Artificial Intelligence and Robotics
subject: human-computer interaction
subject: ai-assisted collaboration
subject: music composition
subject: human-ai interaction

description: We investigate how AI for users can analyze AI for music melody generation and how our tool can help them with it.
The ‘Arab Clans’ Discourse: Narrating Racialization, Kinship, and Crime in the German Media
Creators: name: Özvatan, Özgür
name: Neuhauser, Bastian
name: Yurdakul, Gokce
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: media
subject: critical discourse analysis
subject: corpus linguistics
subject: racism
subject: crime
subject: immigrants
subject: Germany
subject: 300 Sozialwissenschaften

description: In the last decade’s media discourse, particular Arab immigrant groups received the name ‘Arab clans’ and have been portrayed as criminal kinship networks irrespective of actual involvement in crime. We question how ‘Arab clans’ are categorized, criminalized, and racialized in the German media. To answer this question, we collected clan-related mainstream media articles published between 2010 and 2020. Our first-step quantitative topic modeling of ‘clan’ coverage (n = 23,893) shows that the discourse about ‘Arab clans’ is situated as the most racialized and criminalized vis-à-vis other ‘clan’ discourses and is channeled through three macro topics: law and order, family and kinship, and criminal groupness. Second, to explore the deeper meaning of the discourse about ‘Arab clans’ by juxtaposing corpus linguistics and novel narrative approaches to the discourse-historical approach, we qualitatively analyzed 97 text passages extracted with the keywords in context search (KWIC). Our analysis reveals three prevalent argumentative strategies (Arab clan immigration out of control, Arab clans as enclaves, policing Arab clans) embedded in a media narrative of ethnonational rebirth: a story of Germany’s present-day need (‘moral panic’) to police and repel the threats associated with ‘the Arab clan Other’ in order for a celebratory return to a nostalgically idealized pre-Arab-immigration social/moral order.
Compostos bioativos para a saúde e segurança alimentar
Creators: name: Mota, Joana
name: Marques, Cátia
name: Belas, Adriana
name: Teixeira, Daniela
name: Agrícola, Ricardo
name: Resendes, Ana
name: Prazeres, José
name: Lourenço, Armindo
name: Pedroso, Laurentina
name: Santos, Isabel
name: Lima, Ana
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: Atualmente, o tópico dos compostos bioativos para a segurança alimentar tem sido alvo de grande foco, sobretudo numa época em que a utilização de desinfetantes químicos e de antibióticos é cada vez mais evitada na área agro-alimentar, dentro de um contexto One Health. Deste modo, o estudo de compostos moleculares com capacidade de inibir a presença de bactérias ou fungos patogénicos ou de promover uma população microbiana saudável é um campo de investigação cada vez com mais importância. Se por um lado os compostos bioativos naturais têm atraído grande atenção devido aos seus efeitos benéficos para a saúde, sobretudo ao nível da prevenção de doenças inflamatórias e oncológicas, por outro, as suas atividades antimicrobianas podem ser muito úteis para segurança alimentar e para a saúde global, como alternativas a desinfetantes e a antibióticos. É nestas áreas que a nossa equipa dos bioativos e da segurança alimentar trabalha. Iremos apresentar alguns trabalhos mais importantes, exemplificativos do tipo de técnicas e áreas em que nos focamos, que envolvem o isolamento e caracterização de proteínas, péptidos e compostos fenólicos bioativos de alimentos, utilizando diversas metodologias moleculares e celulares, modelos in vitro e in vivo de atividades anti-inflamatórias, anti-tumorais e antibacterianas. Desde a descoberta de uma proteína anti-tumoral no tremoço, ao desenvolvimento de um protocolo de fermentação de soro de queijo para produzir péptidos anti-inflamatórios e antibacterianos, até ao desenvolvimento de alternativas ao sal em carnes, promotores de uma microbiota saudável, à identificação de alimentos para combater a osteoartrite em equinos e as mastites em bovinos, vamos fazer uma viagem pelos vários compostos bioativos que já descobrimos e com os quais temos desenvolvido projetos em colaboração com várias equipas da FMV-ULHT e várias instituições extramuros. Palavras-chave: Compostos bioativos, Alimentos, Anti-inflamatórios, Anti-tumorais, Antibacterianos, One Health. Financiamento: Projetos FMV-ULHT Estratégicos 2021 – OSTEOHEALTH e OP-FEED&FOOD; Projeto FMV-ULHT Exploratório 2021 - Lupine4Weaning. Projeto FCT PTDC/BAA-AGR/28608/2017.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
Additional file 1: of Mindfulness as a complementary intervention in the treatment of overweight and obesity in primary health care: study protocol for a randomised controlled trial
Creators: name: Salvo, Vera
name: Kristeller, Jean
name: Marin, Jesus Montero
name: Sanudo, Adriana
name: Lourenço, Bárbara
name: Schveitzer, Mariana
name: D’Almeida, Vania
name: Morillo, Héctor
name: Suely Gimeno
name: Garcia-Campayo, Javier
name: Demarzo, Marcelo
Publisher: name: Figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SPIRIT checklist. (DOC 137 kb)
Classical Gluon Production Amplitude for Nucleus-Nucleus Collisions: First Saturation Correction in the Projectile
Creators: name: Chirilli, Giovanni A.
name: Kovchegov, Yuri V.
name: Wertepny, Douglas E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We calculate the classical single-gluon production amplitude in nucleus-nucleus collisions including the first saturation correction in one of the nuclei (the projectile) while keeping multiple-rescattering (saturation) corrections to all orders in the other nucleus (the target). In our approximation only two nucleons interact in the projectile nucleus: the single-gluon production amplitude we calculate is order-g^3 and is leading-order in the atomic number of the projectile, while resumming all order-one saturation corrections in the target nucleus. Our result is the first step towards obtaining an analytic expression for the first projectile saturation correction to the gluon production cross section in nucleus-nucleus collisions.
description: 37 pages, 24 figures
Re-Engineering Lumbar Microdiscectomy: From the Bench to the Bedside
Creators: name: CHRISTOPHER DENIS DALY
Publisher: name: Figshare
Year: 2018
Subjects: subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology
subject: 110323 Surgery
subject: FOS: Clinical medicine
subject: Stem Cells
subject: 110314 Orthopaedics
subject: Medicine

description: This thesis explores ways to re-engineer lumbar discectomy surgery, the most commonly performed spine surgery in the word, via pre-clinical and clinical investigation.  The preclinical investigation consists of developing a large animal model of the post lumbar discectomy intervertebral disc and developing a new therapy for disc degeneration using mesenchymal progenitor cells, a type of adult stem cell, pre-treated with the drug pentosan polysulfate. The clinical investigation consists of a survey of Australasian neurosurgeons characterising their lumbar discectomy practices and the protocol for a clinical trial investigating the role, if any, of activity restrictions following lumbar discectomy.
Resistência a antimicrobianos: Para onde caminhamos?
Creators: name: Santos, Raquel
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: O meu nome é Raquel Santos e tenho formação em Biologia Molecular e Genética e Medicina Veterinária. A minha linha de investigação é centrada na bacteriologia, com ênfase na resistência a antimicrobianos. Considerando a importância do conceito Uma Só Saúde, tenho investigado a resistência a antimicrobianos em diversas áreas: No ambiente, em medicina veterinária, em higiene e segurança alimentar e em medicina humana. Entre os projectos mais relevantes onde participei, saliento o estudo da doença periodontal canina e da úlcera do pé diabético. A doença periodontal canina é caracterizada pela presença de uma microbiota, cujas características se modificam com o evoluir do estado clínico do animal, capaz de causar graves implicações sistémicas, nomeadamente endocardite bacteriana. A formação de biofilmes resistentes a antibióticos apresentada por esta microbiota conduziu à necessidade de desenvolver terapias alternativas para o seu combate. A úlcera do pé diabético é uma importante consequência da diabetes, doença que afecta milhões de pessoas em todo o mundo. Devido ao ambiente propício, nomeadamente a vasculopatia, a neuropatia e a imunossupressão, a colonização bacteriana nestas úlceras frequentemente evolui para infecção. A microbiota presente nas infecções do pé diabético tende a organizar-se na forma de biofilmes extremamente recalcitrantes à antibioterapia convencional. Neste I Encontro de Investigação da FMV da Universidade Lusófona, pretendo partilhar com os meus colegas o resultado do estudo de péptidos antimicrobianos, bem como dos seus veículos de administração, contra uma colecção de estirpes bacterianas multirresistentes isoladas de canídeos com doença periodontal e de pacientes com úlcera do pé diabético. Palavras-chave: Biofilme, Doença periodontal, Pé diabético, Péptido antimicrobiano, Resistência antimicrobiana.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
Additional file 1: of Mindfulness as a complementary intervention in the treatment of overweight and obesity in primary health care: study protocol for a randomised controlled trial
Creators: name: Salvo, Vera
name: Kristeller, Jean
name: Marin, Jesus
name: Sanudo, Adriana
name: Lourenço, Bárbara
name: Schveitzer, Mariana
name: D’Almeida, Vania
name: Morillo, Héctor
name: Suely Gimeno
name: Garcia-Campayo, Javier
name: Demarzo, Marcelo
Publisher: name: Figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SPIRIT checklist. (DOC 137 kb)
Self-gravitating systems in Extended Gravity
Creators: name: Stabile, A.
name: Capozziello, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Starting from the weak field limit, we discuss astrophysical applications of Extended Theories of Gravity where higher order curvature invariants and scalar fields are considered by generalizing the Hilbert-Einstein action linear in the Ricci curvature scalar $R$. Results are compared to General Relativity in the hypothesis that Dark Matter contributions to the dynamics can be neglected thanks to modified gravity. In particular, we consider stellar hydrostatic equilibrium, galactic rotation curves, and gravitational lensing. Finally, we discuss the weak field limit in the Jordan and Einstein frames pointing out how effective quantities, as gravitational potentials, transform from one frame to the other and the interpretation of results can completely change accordingly.
description: Review paper; 59 pages, 15 figures
Does the Newton's gravitational constant vary sinusoidally with time? Orbital motions say no
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: A sinusoidally time-varying pattern of the values of the Newton's constant of gravitation $G$ measured in Earth-based laboratories over the latest decades has been recently reported in the literature. We put to the test the hypothesis that the aforementioned harmonic variation may pertain $G$ itself in a direct and independent way. We numerically integrated the ad-hoc modified equations of motion of the major bodies of the Solar System by finding that the orbits of the planets would be altered by an unacceptably larger amount in view of the present-day high accuracy astrometric measurements. In the case of Saturn, its geocentric right ascension $α$, declination $δ$ and range $ρ$ would be affected up to $10^4-10^5$ milliarcseconds and $10^5$ km, respectively; the present-day residuals of such observables are as little as about $4$ milliarcseconds and $10^{-1}$ km, respectively. \textcolor{black}{We analytically calculated the long-term orbital effects induced by the putative harmonic variation of $G$ at hand finding non-zero rates of change for the semimajor axis $a$, the eccentricity $e$ and the argument of pericenter $ω$ of a test particle. For the LAGEOS satellite, an orbital increase as large as $3.9$ m yr$^{-1}$ is predicted, in contrast with the observed decay of $-0.203\pm 0.035$ m yr$^{-1}$. An anomalous perihelion precession as large as 14 arcseconds per century is implied for Saturn, while latest observations constrain it down to the $10^{-4}$ arcseconds per century level. The rejection level provided by Mercury is of the same order of magnitude.
description: LaTex2e, 17 pages, 1 table, 1 figure. Accepted for publication in Classical and Quantum Gravity (CQG)
Observation Research on How Positive Affirmations Impact Self-Esteem
Creators: name: Miller, Jessica
name: Zizhong Xiao
name: Tomlinson, Tracy
name: Charles, Ayana Faith
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: natural observation
subject: positive affirmation
subject: self esteeem

description: In this research, I will be using natural observation research to assess how positive affirmations impact self-esteem.
Grupo de interesse em Biologia Molecular
Creators: name: Ropio, Joana
name: Valença, Andreia
name: Belas, Adriana
name: Amaral, Ana
name: Pires, Ana Elisabete
name: Marques, Cátia
name: Batista, Mariana
name: Serafim, Michelle
name: Van Harten, Sofia
name: Alves, Margarida
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: A biologia molecular é uma área da biologia que se centra na utilização de técnicas baseadas no estudo de DNA, RNA e proteínas. Esta é, também, uma área transversal a virtualmente todas as áreas de investigação científica na atualidade. O recentemente formado Grupo de Interesse em Biologia Molecular (GIBioM) da FMV da Universidade Lusófona tem por objectivo reunir docentes e investigadores com valências técnicas nas várias vertentes de Biologia Molecular. O GIBioM pretende favorecer a partilha de conhecimentos técnicos na área de Biologia Molecular entre colegas com experiência nesta área e, também, potenciar parcerias entre os seus membros com outras linhas de investigação na FMV da Universidade Lusófona, prosseguindo as prioridades desta Unidade Orgânica quanto à criação de equipas colaborativas, multidisciplinares e vocacionadas para a investigação científica. Nesta comunicação iremos apresentar os elementos que integram este grupo bem como alguns trabalhos já desenvolvidos ou em desenvolvimento no âmbito de colaborações existentes entre docentes da FMV da Universidade Lusófona. Palavras-chave: Biologia Molecular, DNA, RNA, GIBioM.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
Reassessment of Progression-Free Survival as a Surrogate End Point of Overall Survival
Creators: name: Liu, Hsuan-Hui Grace
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Progression-free survival (PFS) has been increasingly used as a surrogate endpoint for overall survival (OS) by FDA in cancer drug approval. However, whether PFS can fully represent OS has remained uncertain. Breast cancer is the most prevalent cancer among females, and PFS has been the most common endpoint in drug approval trials for decades. Nevertheless, studies have shown conflicting results on whether PFS correlates with OS among subtypes of breast cancer and across different treatments. This study aims to reassess the correlation between PFS and OS in breast cancer, and evaluate under what circumstances can we consider using PFS as a surrogate of OS.
Is Open Science possible with clinical data? Tools for planning and risk assessment
Creators: name: Rodrigues, Joana
name: Castro, João
name: Ribeiro, Cristina
name: Matos, Paula Mena
name: Sales, Célia
Publisher: name: Zenodo
Year: 2020

description: Poster presented at the XLVIII Congreso de la Sociedad Española de Medicina Psicosomática, Zaragoza, Spain.
Examining the Impact of Persistent Social Media Engagement on Self-Esteem
Creators: name: Tomlinson, Tracy
name: Cope, Donell Haywood
name: Zizhong Xiao
name: Miller, Jessica
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Observational research
subject: Outcome variable
subject: Causal variable

description: I will be viewing the comments of people who have been using social media for a while and determining if they have any matching traits with low self-esteem.
Reaction probability and defluorination mechanisms of a potent greenhouse gas SF5CF3 attacked by CH3 radical: a theoretical study
Creators: name: Liu, Yan
name: Yue-Tian Huang
name: Wang, Wen-Liang
Publisher: name: Figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: Computational Biology

description: The defluorination mechanisms for the reactions between SF5CF3 and CH3 radicals were investigated by using the B3PW91/6-311++G(d,p) method. Optimised geometries of all the species (reactants, transition states, products and intermediates) were verified by the analysis of vibration frequency and intrinsic reaction coordinate. The energies were refined by the higher method of G3MP2. The results show that SF5CF3 is easier to be attacked by the carbon rather than the hydrogen atom of CH3 radical. Moreover, the F atom on the molecular axis (Fa) of SF5CF3 molecule is easier to be extracted than others [the F atom perpendicular to the molecular axis (Fb) or in -CF3 group(Fc)] because the barrier of transition state TS1 is 26.9 or 92.7 kJ mol−1 lower than that of TS2 or TS3, respectively. The most favourable channel for the title reactions are R→TS1→Dp1→TS7→CP-1→Dp4[CF3SF3+CH2F+HF]. The three-parameter-fitted Arrhenius expressions of the two elemental steps R→TS1→Dp1 and Dp1→TS7→CP-1 are  and , respectively. The tunnelling effect is more significant for the reactions involving lighter atom or molecule group, especially in lower temperatures.
A genómica “das coisas” no conceito One Health
Creators: name: Gomes, João Paulo
Publisher: name: Revista Lusófona de Ciência e Medicina Veterinária
Year: 2022

description: O presente Abstract pretende ilustrar as principais linhas de investigação do Laboratório que coordeno no Instituto Ricardo Jorge, agora em estreita colaboração com a FMV, abrindo a porta a alunos e docentes da FMV a desenvolverem a sua investigação com a nossa colaboração no fantástico mundo da genómica microbiana. Venho mostrar, por exemplo, como identificámos as características genómicas e evolutivas do vírus Monkeypox, o qual, tendo como hospedeiro natural pequenos roedores, está agora a causar um surto mundial. Ou como a demonstração de uma improvável transmissão animal-homem num zoo vem desafiar o que se pensa saber sobre a origem da tuberculose nas “Américas”. Ou como a genómica em Toxoplasma gondii nos ajudou concluir que é possível diminuir o número de ratinhos de laboratório que são necessários para a manutenção e estudo deste parasita. Finalmente, e não menos importante, a forma como a genómica nos permite perceber a origem de surtos infeciosos, identificando cadeias de transmissão que envolvem alimentos, animais, o ambiente e o Homem, em toda a dimensão do conceito One Health. Convido-vos assim a mergulharem comigo nesta “sopa de letras” que é a sequência genética dos micróbios que nos rodeiam, e que, para além de reescreverem séculos de história, nos ensinam também o quanto a nossa saúde depende dos animais com que convivemos e do ambiente em que vivemos. Palavras-chave: Genómica, Doenças infeciosas, One Health.
description: Revista Lusófona de Ciência e Medicina Veterinária, v. 13 (2022): I Encontro de Investigação da FMV da Universidade Lusófona- Edição Especial
Effect of Positive Relationships on Self-Esteem
Creators: name: Nusayba Khaled Abd-Elmoniem
name: Miller, Jessica
name: Zizhong Xiao
name: Tomlinson, Tracy
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: positive relationships
subject: observational research
subject: self esteem

description: Using a naturalistic approach, the study will observe individuals' behaviors and interactions with others in their daily lives to understand how positive social connections influence their self-esteem.
Most appropriate information communication technology for health education in HIV management in rural communities: a systematic review
Creators: name: Bester, Petra
Publisher: name: Figshare
Year: 2018
Subjects: subject: 111712 Health Promotion
subject: FOS: Health sciences
subject: 111717 Primary Health Care

description: Most appropriate information communication technology
for health education in HIV management in rural communities: a systematic
review

TL Malinga, P Bester, K Smit

Presenting author’s e-mail:
petra.bester@nwu.ac.za

Africa Unit for Transdisciplinary Health Research
(AUTHeR) Faculty of Health Sciences, North-West University (NWU),
Potchefstroom, South Africa

BACKGROUND

HIV management (testing, disclosure, ART, etc.) implies complex regimens
activated and monitored within overburdened health systems. Innovative health
education extending beyond facility borders needed to inform and empower
citizens. ICT has such potential in rural contexts. Nearly two decades into
eHealth and multiple ICT-related research, the most appropriate ICT in rural
communities remains uncertain.

OBJECTIVE

To identify most appropriate ICTs for health education in HIV management
in rural communities.

METHOD

Systematic review methodology was rigorously followed. The technology acceptance model (TAM) and
eHealth model for developing countries framed this review. Articles
published on appropriateness of ICT for HIV management in rural communities
were eligible for inclusion. Several databases were searched, using MeSH and
key terms separated by Boolean operators. Searches were limited from 1999 to 2016.

RESULTS

Forty-five articles were retrieved (through electronic searches and
other resources), of which seven (n7) were eligible for inclusion (n4
quantitative -, n5 qualitative designs). Articles were analysed according to
ease-of-use and usefulness (from TAM); context, content, connectivity,
capacity, community (from eHealth model). ICTs used were sms/mobile phones
(n4); personal development assistant (PDA) (n1), website (n1);
various/non-specified (n3). Ease-of-use was recognised (n8), but usefulness
less prominent. Awareness of rural context was reported. Connectivity wasn’t
always possible but not a limiter. ICT may fortify inequality, but can unlock
capacity.

CONCLUSIONS

Despite the known potential of ICT, evidence remains scattered. SMS more feasible within rural
communities. Ease-of-use exceeded usefulness. Challenge the traditional,
consider first the context and connectivity, then the content. 
Assessment of the District Health Information System in the North West Province
Creators: name: Bester, Petra
Publisher: name: Figshare
Year: 2018
Subjects: subject: 111711 Health Information Systems (incl. Surveillance)
subject: FOS: Health sciences

description: Assessment of the District Health Information System
in the North West Province

aP Bester, bMS
Lubbe, cA Robinson, dJ Clase, bJR Burger, bM
Malik

Presenting author’s e-mail:
petra.bester@nwu.ac.za

aAfrica
Unit for Transdisciplinary Health Research (AUTHeR) Faculty of Health Sciences,
North-West University (NWU), Potchefstroom, South Africa

bMedicine Usage in South Africa (MUSA) Faculty of
Health Sciences, NWU, Potchefstroom, South Africa

cProvincial
Office, North West Department of Health, Mahikeng, South Africa

dSchool
of Nursing Science, Faculty of Health Sciences, NWU, Potchefstroom, South
Africa

BACKGROUND

Several apprehensions regarding data quality
generated by the District Health Information System (DHIS) were reported. Manual processes integrated
with incompatible computerised systems reduced data quality.

OBJECTIVES

DHIS was assessed in 2015 in collaboration with the
North West Department of Health to inform policies related to comprehensive
eHealth challenges based on empirical evidence.

METHODS

·
Phase 1 a quantitative qualitative design was
followed. All-inclusive
sample of estimated employee complement (N=1410) was invited to participate. A descriptive cross-sectional
design lead to data collected from all levels and service points within the Dr Kenneth
Kaunda and Bojanala Platinum Districts. Eight facility/level-of-care-specific
questionnaires regarding input, output, process factors of DHIS were completed
and statistically analysed. Data collection on different service-levels implied
fluctuating sample sizes. Qualitative, interpretive descriptive design followed
with individual interviews with managers (n=23) regarding the DHIS.

·
Phase
2 shared preliminary results in collaborative seminars in June 2016.

·
Phase
3 integrated results towards final conclusions and recommendations.

RESULTS

Five clusters of conclusions with recommendations emerged.
Conclusions related to training; data quality; lack of ownership and
insufficient data usage; human resources and associated technology adoption;
ICT and systems-specific conclusions.

CONCLUSION

Urgent need for multi-level, purposive
training to all service-levels. Top-down system of multiple hand-to-hand
actions from bottom-up compromised data quality. Migration from technology
adoption towards integration in process with insufficient data usage.
Connectivity, insufficient equipment and poor ICT maintenance detrimental to
DHIS progress and unprepared for DHIS2. To consider operations software leading
to once-off data capturing by health practitioners.
Success and failure of the plasma analogy for Laughlin states on a torus
Creators: name: Fremling, Mikael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the nature of the plasma analogy for the Laughlin wave function on a torus describing the quantum Hall plateau at $ν=\frac{1}{q}$. We first establish, as expected, that the plasma is screening if there are no short nontrivial paths around the torus. We also find that when one of the handles has a short circumference -- i.e. the thin-torus limit -- the plasma no longer screens. To quantify this we compute the normalization of the Laughlin state, both numerically and analytically. For the numerical calculation we expand the Laughlin state in a Fock basis of slater-determinants of single particle orbitals, and determine the Fock coefficients of the expansion as a function of torus geometry. In the thin torus limit only a few Fock configurations have non-zero coefficients, and their analytical forms simplify greatly. Using this simple limit, we can reconstruct the normalization and analytically extend it back into the 2D regime. We find that there are geometry dependent corrections to the normalization, and this in turn implies that the plasma in the plasma analogy is not screening when in the thin torus limit. Further we obtain an approximate normalization factor that gives a good description of the normalization for all tori, by extrapolating the thin torus normalization to the thick torus limit.
description: 28 pages, 13 figures + 10 pages supplementary material. v3: Moved parts to supplementary material v2: Major changes compared to v1