cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In practice: interoperability and data management in SSH
Creators: name: Degl'Innocenti, Emiliano
name: Manuel, Adeline
name: Larousse, Nicolas
name: Concordia, Cesare
name: Michaud, Geneviève
name: Bottoni, Gianmaria
name: Wittenberg, Marion
Publisher: name: Zenodo
Year: 2022
Subjects: SSHOC
Social Sciences and Humanities Open Cloud
European Open Science Cloud
EOSC
Interoperability
data management in SSH
AïOLI
RESTORE
Web Panel Sample Service
WPSS
Archive in a Box
Dataverse

description: Moderator: Emiliano Degl'Innocenti (CNR, E-RIHS) Platforms for GLAM institutions: AïOLI - Adeline Manuel (CNRS) RESTORE - Emiliano Degl'Innocenti, Carmen Di Meo, Francesco Coradeschi, Maurizio Sanesi, OVI Research Fellows (CNR, OVI) Citation prototype as a data management tool - Nicolas Larousse (CNRS, DARIAH), Cesare Concordia (CNR, ISTI) The Web Panel Sample Service (WPSS) for cross-national surveys and panels - Gianmaria Bottoni (ESS Survey), Geneviève Michaud (SciencesPO, CDSP) The 'Archive in a Box', based on Dataverse - Marion Wittenberg & Vyacheslav Tykhonov (DANS-KNAW)
Additional file 1: of Gene-diet interaction effects on BMI levels in the Singapore Chinese population
Creators: name: Chang, Xuling
name: Dorajoo, Rajkumar
name: Sun, Ye
name: Han, Yi
name: Wang, Ling
name: Khor, Chiea-Chuen
name: Sim, Xueling
name: Tai, E-Shyong
name: Liu, Jianjun
name: Yuan, Jian-Min
name: Koh, Woon-Puay
name: van Dam, Rob
name: Friedlander, Yechiel
name: Heng, Chew-Kiat
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health
subject: Hematology

description: Table S1. SNP information and Meta-analysis between 78 SNPs and BMI level. Table S2. Interaction between SNPs and AHEI-2010 dietary score on BMI. Table S3. Interaction between SNPs and total calories on BMI. Table S4. Interaction between SNPs and %protein on BMI. Table S5. Interaction between SNPs and út on BMI. Table S6. Interaction between SNPs and %SFA on BMI. Table S7. Interaction between SNPs and %MUFA on BMI. Table S8. Interaction between SNPs and %PUFA on BMI. Table S9. Interaction between SNPs and Êrbohydrate on BMI. Table S10. Interaction between SNPs and %starch on BMI. Table S11. Interaction between SNPs and fiber on BMI. Table S12. Interaction between SNPs and cholesterol on BMI. Table S13. Interaction between GRS and dietary factors on BMI in individual datasets used in the study. (PDF 1521Â kb)
title: Nanny von Escher
title: geboren den 4. Mai 1855, gestorben den 22. Juli 1932
titleType: Subtitle
Creators: name: Huber, Max
Publisher: name: [Verlag nicht ermittelbar]
Year: 1932
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Escher, Nanny von
subject: Zürich

description: Enth.: Ansprache des Professors Dr. Max Huber
SLIDEpresentation_Sociedad española de psicofisiología y neurociencia cognitiva y afectiva SEPNECA Septiembre 2021. POSTER PRESENTATION “Virtual Labs. Sci-Training. An open science interface for interactive scientific visualization in neuroscience.”
Creators: name: Eloisa Ruiz-Marquez, Centre Of Psychology MAP Institute
Publisher: name: OSF Registries
Year: 2023
Subjects: active learning
cognitive neuroscience
interactive scientific visualization
learning
psychology
teaching innovation

description: Scientific productivity is mainly based on scientific literature. But even for scientists it is not always easy to understand an experiment. At university, students struggle to form a mental image of what is being done in research, and for people with a different professional activity, it is difficult to understand scientific publications. However, they usually need to make their decisions based on scientific evidence. During the last decade, many tools have been developed for facilitating open data resources, improving replicability and science’s quality. Moreover, audio-visual material and license-free software have helped to learn science easily. But still today, the comprehension of science is a handicap, particularly in the field of experimental psychology and cognitive neuroscience. Active learning is based on the idea that people learn by interacting and manipulating reality. Science is something that is done. We learn it not just by studying, reading, listening, or watching it, but mainly, by doing it. Virtual-Labs is a space that will allow scientists to build their experiments easily. For readers, it will be an immersive framework where they will progressively develop the experiment. Virtual-Labs will be based on Shiny apps, an R package for interactive web apps. Initially, a prototype about brain video games research will be built. Secondly, the app will be tested in online sites and e-devices. Then, a beta project will start as an open resource and will be evaluated to improve experience.
title: Enhancement of hydrogen terminated diamond FET performance through integration of electron acceptor oxides
Creators: name: Macdonald, David Andrew
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Diamond, high power, field effect transistor, FET, hydrogen termination, surface transfer doping, MoO3, V2O5, wide band gap, electron acceptor oxide, surface transfer doping oxide.

description: This work reports on the improvement to the performance of hydrogen terminated diamond field effect transistors (FETs) by replacing surface adsorbed atmospheric species with transition metal oxides MoO3 and V2O5, and the implementation of a pre-deposition vacuum anneal at 400°C which is required to maintain the stability of the doping within the devices. MESFET structures incorporating a metal/H-diamond gate contact were observed to be irreversibly damaged by exposure to the 400°C pre deposition vacuum annealing prior to deposition of MoO3 or V2O5. Therefore preliminary investigation of devices including the MoO3 or V2O5 without pre annealing was carried out. An increase in maximum drain current of up to 50% was observed when comparing output characteristics before and after deposition of MoO3 or V2O5 without the 400°C pre anneal. Following this, investigation of the inclusion of Al2O3 into the FET structure as a gate dielectric was explored in order to increase the thermal robustness of the gate and allow inclusion of the pre deposition vacuum annealing at 400°C. It was shown that FETs fabricated using Al2O3 as a gate dielectric maintained transistor operation after vacuum annealing at 400°C and deposition of 10nm of MoO3 or V2O5. FETs were characterized after exposure to atmospheric adsorbates, and after deposition of 10nm of MoO3 or V2O5 and pre deposition 400°C vacuum anneal. FETs with Al2O3 gate dielectric using V2O5 and pre deposition annealing showed an increase in drain current of up to 276%. The V2O5 FETs using Al2O3 as a gate dielectric showed maximum drain currents of -376mA/mm, extrinsic transconductances of 97mS/mm, and on resistances as low as 17Ω.mm. These are important parameters for assessing the performance of power FETs.
Additional file 1: of Development and evaluation of novel tumor-targeting paclitaxel-loaded nano-carriers for ovarian cancer treatment: in vitro and in vivo
Creators: name: Yao, Shu
name: Li, Li
name: Su, Xuan-tao
name: Wang, Kai
name: Lu, Zai-jun
name: Yuan, Cun-zhong
name: Feng, Jin-bo
name: Yan, Shi
name: Kong, Bei-hua
name: Song, Kun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: STR for A2780, SK-OV-3 and HO-8910 cells. (DOC 75 kb)
The forensic toxicology of antipsychotic drugs: method development, stability and redistribution studies
Creators: name: Saar, Eva
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Antipsychotic drugs are commonly prescribed for the treatment of a number of metal illnesses. However, people suffering from mental illness are at a higher risk of suicide than healthy individuals and these drugs are associated with the onset and exacerbation of particular comorbidities. Accordingly, antipsychotic drugs are commonly detected in cases reported to the coroner. The detection and quantification of antipsychotic drugs in postmortem specimens and the ensuing interpretation of these results therefore play an important role determining the cause of death. A study is presented which describes the development of a comprehensive detection method for the analysis of antipsychotic drugs in whole blood, as well as research into several factors that can potentially alter blood concentrations after death, with a focus on post-mortem redistribution and stability of blood samples containing antipsychotic drugs. The research indicated that several antipsychotic drugs are prone to significant losses if stored at temperatures above 0 ºC, potentially compromising post-mortem drug results. Furthermore, the atypical antipsychotic drug olanzapine showed significant losses even if stored at temperatures below 0 ºC. Further analysis of the degradation of this commonly prescribed drug revealed 2-hydroxymethyl olanzapine as a new degradation product of olanzapine in aqueous solutions. The investigation of the post-mortem redistribution of antipsychotic drugs in peripheral blood specimens revealed that the majority of targeted drugs underwent a time-dependent bi-phasic process with an initial increase followed by a decrease in concentration. However, different patterns of change were also present. The results highlighted the need for immediate sample collection post-admission of a deceased person to the mortuary, in addition to appropriate sample storage; pre- and post-analysis. When interpreting post-mortem blood results of antipsychotic drugs, the factors described in this thesis must be considered as sources of potential variation.
title: Factors affecting the implementation of a National Digital Health & Wellbeing Service at scale
Creators: name: Egbunike-Agbakoba, Ruth Ngozika Ifunanya Obianuju
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Digital health, implementation, normalisation process theory, scale, barriers, facilitators, informatics, eHealth, process evaluation.

description: No abstract available.
International student satisfaction with university services at Victorian universities
Creators: name: Padlee, Siti Falindah
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: International student enrolments make a vital economic contribution to the Australian economy. Because of the importance of international students to the economy, a number of studies have emerged examining the subject of international students in Australia in relation to their living experiences, attitudes and behaviour. In spite of this, very few studies have examined international students’ overall satisfaction with their university experience. This study therefore examines international students’ satisfaction with six service factors in Victorian universities. This study also examines student satisfaction as an antecedent of behavioural intentions and how different student characteristics moderate the relationship between overall satisfaction and behavioural intentions (e.g. intention to spread positive word of mouth about their university to others, intention to re-enrol with their university and willingness to recommend their university to others). An online survey was distributed to four participating universities. Structural equation modeling (SEM) and multiple regression were employed to analyse the main research questions, whilst descriptive analysis and inferential analysis were employed to analyse the subsidiary research questions. The results from the SEM analysis revealed that overall student satisfaction is influenced by the level of satisfaction with academic services, courses offered, access (i.e. the accessibility to campus buildings and facilities, library operating hours and the various clubs and societies for students) and augmented services. In contrast, administrative services and physical evidence were found to have a non-significant impact on overall satisfaction. Analysis also revealed a strong relationship between overall satisfaction and behavioural intentions. The results from the multiple regression analysis show that the various student characteristics under study (e.g. gender, nationality and education level) do not moderate the relationship between students’ overall satisfaction and behavioural intentions. This thesis concludes by discussing the various contributions made by this study to both academics and practitioners. It also details several recommendations for future research and for attracting and retaining international students to Australian universities.
title: Genetically engineered Mouse Models reveal a tumourigenic collaboration between Sdhb deficiency and oncogenic Hras
Creators: name: Däbritz, Jan Henry Matthias
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Cancer, genetically engineered mouse model, metabolism, metabolomics, renal cell carcinoma, succinate dehydrogenase.

description: The mitochondrial tumour suppressor succinate dehydrogenase is found inactivated in several tumour entities, amongst them SDH–deficient renal cell carcinoma (RCC) and pheochromocytoma/paraganglioma (Pheo/PGL). An in-depth understanding of cooperating events that enable malignant transformation of SDH-deficient tissues and preclinical model systems of SDH-deficient malignancies are still lacking. The first major goal of this thesis project was to generate a genetically engineered model of SDH-deficient RCC as an easy-to-monitor pathology in mice. In addition, we set out to study tissue-specific phenotypes resulting from stochastic Sdhb loss in peripheral organs. Driven by a Cadherin 16 promoter (KspCre) and thus in the distal renal tubular system, a fatal cystic degeneration of Sdhbfl/fl kidneys resulted from Cre expression. Ongoing untargeted metabolomics analyses of kidney, plasma and urine specimens obtained from this model hold potential for discovery of new biomarkers of SDH-deficient tumours. In a RosaCreERT2-based model, dramatic weight loss within the first weeks after transgene induction correlated with succinate accumulation in peripheral organs of Sdhbfl/fl, Hraswt/wt animals. Less intense transgene induction schemes resulted in long-term survival irrespective of Sdhb status. To the best of my knowledge, this work describes the first, albeit not perfect, genetically engineered mouse model of SDH-deficient RCC. Ongoing experimental efforts focus on reliable identification of systemic metabolic biomarkers that could improve monitoring of patients who are at (relapse) risk of SDH-deficient tumours.
title: A search for top-antitop quark resonances with the ATLAS detector at the LHC
Creators: name: Duncan, Anna
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: LHC ATLAS.

description: Various extensions to the Standard Model postulate the existence of heavy particles that decay to a top-antitop quark pair. If one of these particles exists with a mass of a few TeV then it may be produced during proton-proton collisions at the Large Hadron Collider (LHC). The analysis presented in this thesis searches 36 fb−1 of √s = 13 TeV proton- proton collision data collected by the ATLAS detector for evidence of a top-antitop quark resonance, and sets upper limits on the production cross section of new heavy particles in a set of benchmark models. The observed top-antitop quark invariant mass spectrum agrees well with the spectrum expected under the Standard Model and no evidence of a top-antitop quark resonance is found. A 1% width Z′ boson in a topcolour-assisted technicolour model is observed to be excluded at masses below 3.0 TeV, a 30% (15%) width Kaluza-Klein gluon in a Randall-Sundrum model is observed to be excluded at masses below 3.7 TeV (3.8 TeV), and a 3-6% width Kaluza-Klein graviton in a Randall-Sundrum model is observed to be excluded in the mass interval 0.45 < mGKK < 0.65 TeV. Some techniques developed to improve the sensitivity of the analysis are described: a new method of electron-in-jet overlap removal and a reconstruction of semi-boosted and very boosted top-antitop quark decay topologies. A study evaluating the prospects of this search at the High Luminostiy LHC is also presented. It estimates that a search of 3000 fb−1 of proton-proton collision data collected using an upgraded ATLAS detector will be able to exclude a Z′ boson at masses below 4 TeV.
title: Examining clinical homologues of “Hikikomori”: development of a scale assessing social withdrawal in young people in Scotland. And clinical research portfolio
Creators: name: Dzik, Kamila
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Social withdrawal, hikikomori, scale development.

description: Background: Social withdrawal contributes to poor emotional, behavioural, social and occupational functioning. In Japan, social withdrawal affecting adolescents and young adults has been conceptualised as a syndrome called Hikikomori (Saito, 2013). At present no adequate measure exists that would support targeted assessment of the presence and severity of social withdrawal amongst adolescents in Scotland. The Glasgow Hikikomori Scale (GHS) is a new measure developed with the aim of providing an English language rating scale for social withdrawal in young people. Aims: This study aimed to develop and conduct preliminary investigation of a new measure for assessing social withdrawal in young people, the GHS. Methods: The first part of this feasibility study involved refinement of the GHS. Clinicians working in Child and Adolescent Mental Health Services (CAMHS) were invited to take part in the online feedback survey regarding the wording of this scale. The second part of this feasibility study involved recruiting the participants to explore the psychometric properties of the GHS. Participants between the age of 13 and 17 with varying levels of social withdrawal were sought from the NHS GG&C CAMHS. The GHS and a mixture of self-report and observer-report scales were used. Results: Forty-nine clinicians from the NHS Greater Glasgow & Clyde (GG&C) area working in the CAMHS took part in the rating of the GHS items on the scale ranging from 1 (very unclear) to 9 (perfectly clear). The median scores of the items ranged from 6 (IQR: 3, 7) to 9 (IQR: 8, 9). The GHS scale was refined in accordance with the received feedback. We then attempted to examine the utility and psychometric properties of the scale by applying it to the assessment of young people with social withdrawal. Recruitment proved to be very challenging with only five people completing the measures in a period of three months. This sample size did not allow to use statistical methods of analysis that were planned to explore the psychometric properties of the GHS. However, the data provided useful information about the challenges of accessing and engaging this sub-group of withdrawn young people. Conclusions: Although only a very small sample was recruited, it allowed to explore the feasibility of the recruitment of this hard to reach population. It also enabled to estimate the time scale necessary to increase the feasibility of the future studies and identify some of the factors that could hinder the recruitment process. Based on the collected data, the recruitment period needed to get a full sample would be approximately 20 months. Future studies will either need to have very long recruitment timeframes or different research methods may need to be used to access usable data on this withdrawn and socially isolated population.
title: Towards the total synthesis of Thapsigargin
Creators: name: Jeuken, Alan
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Total synthesis, Thapsigargin, Ring Closing Ene-yne metathesis, RCEYM, SERCA.

description: Thapsigargin is a sesquiterpene lactone of the guaianolide class whose structure was first assigned in 1984. It is a highly cytotoxic agent, inhibiting the sarco/endoplasmic Ca2+- ATPase (SERCA) at sub-nanomolar concentrations (KD = 0.4 nM), and its prodrug formulations have been of intense interests for many oncological applications. In collaboration with the group of J.-P. Férézou, a strategy towards the construction of the carbon skeleton of thapsigargin and related natural and unnatural analogues was developed based on a ring-closing ene-yne metathesis (RCEYM) step. In this work the scope of that strategy was expanded to fulfil the enantioselectivity requirement of the synthesis via the use of asymmetric transfer hydrogenation under dynamic kinetic resolution conditions on a cyclopentenone γ-ester. These enantioenriched cyclopentenone derivatives have then been used to construct [5,7]-bicyclic structures with varying substitutions. These resulting bicyclic derivates were sensitive to many subsequent reaction conditions, however a robust synthetic strategy was found to chemoselectively oxidise the C-7/8 double bond and from there further derivation was possible, resulting in an advanced [5,7,5]-tricyclic derivative. Finally, the flexibility of the RCEYM strategy was demonstrated through the concise synthesis of an unnatural [5,8]-bicyclic thapsigargin core analogue from a common ketone precursor.
title: Constellating the real
Creators: name: Doohan, Carmel
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Realism, constellation, new-materialism, mimesis.

description: This thesis comprises a novel and a critical essay. Both investigate the philosophical, political and aesthetic implications of trying to understand and write the real, focusing on mimesis, interpretation, boundary-making and the possibility of connection. Although each piece can stand-alone, they have been developed in tandem, with each feeding into and informing the other. My critical essay draws on a wide range of theoretical arguments to explore the possibilities for a new multidisciplinary understanding of realism. The importance of the mimetic faculty in our existential reality and a focus on the materiality of language are crucial to my argument. I explore how pattern decipherment is a fundamental part of our being-in-the-world and offer a re-working of the post-structuralist split between word and thing. Responding to arguments discussed in the essay, my novel questions the idea of fixed boundaries and the dangers of binary thinking. It consciously shows how narrative is co-created through a cognitive, pattern-making desire to form a whole from disparate parts, problematizing any realism that claims to impart a fixed truth or objective 'external' reality. The novel explores the material and linguistic ways in which narratives are created, incorporating discourses of epigenetics, big data and psychometric testing. Its fragmented style combines theory, scientific discourse and autofiction to create the experience of an everyday in need of constant interpretation, a dissonant paradox that combines a deeply interconnected materiality reality with an experience of it that is continually interrupted and alienated. Through fragmentation and the play of the seemingly random, I critique the information-overload of our contemporary digital everyday, exploring how the logic of equivalence and simultaneity can affect the sense-making patterns that structure our reality. The novel functions as a constellation, achieving narrative through a mimetic reading of relation, resemblance and analogy. I argue that the constellation - as an arrangement of the unfixed yet readable, and the creation of meaning through open, changing relations rather than fixity – offers a form able to interact with, and write, the interdependent, symbiotic real it exists within.
Data-centric parallel debugging technique for petascale computers
Creators: name: Dinh, Minh Ngoc
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Petascale computers and computing systems have the potential to solve large-scale, data-intensive problems in science and engineering. Petascale scientific applications, such as the Weather Research and Forecasting Model (WRF), involve enormous multi-dimensional data structures and operate with hundreds of thousands of concurrent processing threads. On the one hand, programming languages and environments have evolved significantly to support parallel application developers to explore the advantages in terms of computational power and memory usage. Co-array Fortran, Split-C, MPI and OpenMP are some successful examples. On the other hand, debugging tools for highly parallel software are still immature, especially in techniques for controlling multiple processes and monitoring large scale data structures during debugging time. Typically, contemporary parallel debuggers allow users to control more than one processing thread while supporting the same examination and visualisation operations that of sequential debuggers. This approach restricts the use of parallel debuggers when it comes to large scale scientific applications run across hundreds of thousands compute cores. First, manually observing the runtime data to detect error becomes impractical because the data is too big. Second, performing expensive but useful debugging operations, such as distributed expression evaluation, becomes infeasible as the computational codes become more complex, involving larger data structures, and as the machines become larger. This thesis explores the idea of a data-centric debugging approach, which could be used to make parallel debuggers more powerful. It discusses the use of ad-hoc debug-time assertions that allow a user to reason about the state of a parallel computation. These assertions are modeled on programming language systems that support the verification and validation of program state as a whole rather than focusing on that of only a single process state. The advantage of this approach is the capability to reason about the massive data structure at runtime. Furthermore, on parallel machines, the debugger‟s performance can be improved by exploiting the underlying parallel platform. The available compute cores can execute parallel debugging functions while idling at a program breakpoint.
The effect of interrupted ageing on the strength and elongation of precipitation hardened aluminium alloys
Creators: name: Chen, Yu
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Yield strength and elongation are both important properties of engineering alloys, but they typically exhibit an inverse correlation and engineers are forced to design around this constraint in applications of the alloys. It was recently reported that precipitation hardenable Al alloys subjected to a new type of heat treatment called ‘interrupted ageing’ exhibited simultaneous increases in both yield strength and elongation, i.e. the inverse correlation was broken. This finding is of considerable technological significance but the physical origin of the effects is not currently understood. The objective of this study is to develop a quantitative explanation for the simultaneous enhancement of yield strength and uniform elongation in age hardenable Al alloys subjected to the interrupted ageing schedule. The investigation of the simultaneous improvement of yield strength (y) and uniform elongation (u) in a model Al-4Cu-0.05Sn (wt. %) alloy has been the main focus of this work and a quantitative model explaining the improvements has been developed. The experiments confirm the reports of Lumley et al. that simultaneous improvements in both y and u are possible through the interrupted ageing procedure. Low temperature ageing of the model Al-4Cu-0.05Sn alloy induces the precipitation of a fine distribution of shearable GP zones with no major change in the precipitate distribution that is formed in the elevated temperature step of the interrupted ageing schedule. Tensile tests demonstrate that the strain hardening behaviour of the samples with and without GP zones is approximately the same at low strains (
The molecular programs controlling follicular helper T cell differentiation and function
Creators: name: Tsai, Louis Meng-Chin
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The phenomena of T cell providing assistance to activated B cells is one of the fundamental requirement for the establishment of effective, and long-term immune protection against invading pathogens. The generation of effective antibody response is an orchestrated process that is both procedural and highly regulated. While the product of this process is required for efficacious immune protection, disregulation of any of its processes can just as easily lead to an immune response against self. We explored the functional role of the master transcriptional factor, BCL6, in orchestrating antibody responses in an extrafollicular response and also how BCL6 regulate microRNAs to influence T cell identity. Lastly, we demonstrated that during CD4+ helper T cell response, a distinct population of circulating CXCR5+ PD1+ cell emerges. This population of cells is capable of rapidly differentiate into mature, canonical T follicular helper cells upon antigen stimulation.
An investigation of the psychosocial correlates to optimal health management in young people with type 1 diabetes
Creators: name: Buttigieg, Kelly Maree
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Type 1 diabetes (T1D) presents considerable challenges to affected children and their families. Medical complications arising from poorly managed T1D may be present from a young age, and worsen over time. It is imperative that illness management is as optimal as possible from a young age, in order to establish a pattern of positive health management lasting into adulthood. Studies of adults and adolescents also demonstrate psychological complications associated with T1D, with implications for medical outcomes. However, these relationships remain relatively underexplored in Australian children. Investigating psychological wellbeing in children engaged with current treatment options is also needed, as the greater flexibility offered by contemporary treatment regimens may be less psychologically demanding. The aim of the current study was to investigate the role of specific psychosocial factors as barriers to optimal illness management in children and adolescents with T1D. As psychosocial wellbeing has previously been reliably linked to illness management in studies of adults and adolescents with T1D, psychosocial outcomes were also of interest. Eighty child and adolescent participants were recruited from a paediatric outpatient diabetes clinic at an Australian hospital. Participants were aged between 7 and 15 years, and held a diagnosis of T1D for at least twelve months. Participants completed written measures which assessed depressive and anxiety symptoms, family functioning, self-efficacy, coping and T1D knowledge. In order to assess illness functioning, T1D outcomes were determined by HbA1c level, and the number of school days missed. Discriminant function analysis was used to explore differences between groups of children and adolescents on several outcomes. Significant differences between groups on the basis of depressive symptoms, coping, family functioning and school days missed were identified. Glycaemic control was not significantly associated with psychosocial wellbeing. The results are discussed individually with a view to identifying markers of problems in psychosocial and illness functioning in Australian children and adolescents with T1D. The findings highlight the importance of specific individual and family factors in the psychosocial wellbeing and illness functioning in this group. This information may assist in the refinement of existing clinical interventions which aim to improve psychosocial and illness outcomes in young people with T1D.
Additional file 1 of MicroRNA-455-3p regulates proliferation and osteoclast differentiation of RAW264.7 cells by targeting PTEN
Creators: name: Zhang, Xiaolu
name: Wang, Liangming
name: Huang, Nianlai
name: Zheng, Yiqiang
name: Cai, Liquan
name: Ke, Qingfeng
name: Wu, Shiqiang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1.
Additional file 1 of Determinants of induced abortion among women received maternal health care services in public hospitals of Arba Minch and Wolayita Sodo town, southern Ethiopia: unmatched case–control study
Creators: name: Abebe, Mesfin
name: Mersha, Abera
name: Degefa, Nega
name: Gebremeskel, Feleke
name: Kefelew, Etenesh
name: Molla, Wondwosen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. English version information sheet. Amharic version information sheet and consent form.
title: Pesticides monitoring with beehives data evaluation from a hazards perspective
Creators: name: Niell, Silvina
name: Santos, Estela
name: Silva, Ivana
name: Jesús, Florencia
name: Dorrego, Melina
name: Genolet, Romina
name: Pequeño, Fiamma
name: Gérez, Natalia
name: Cesio, Verónica
name: Heinzen, Horacio
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2025
Subjects: subject: 630

description: Julius-Kühn-Archiv, vol. 481Hazards of pesticides to bees, 16th International Symposium of the ICP-PR Bee Protection Group, - Proceedings -; 15th - 17th October, 2024; Sevilla (Spain), p. 36
Supplementary Information from Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition.
Creators: name: Koch, Franziska
name: Müller, Michael
name: König, Finja
name: Meyer, Nina
name: Gattlen, Jasmin
name: Pieles, Uwe
name: Peters, Kirsten
name: Kreikemeyer, Bernd
name: Mathes, Stephanie
name: Saxer, Sina
Publisher: name: The Royal Society
Year: 2018

description: Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and their nanofibrillar structure. Thus, self-assembling peptide hydrogels might be suitable scaffolds for regenerative therapies and tissue engineering. Owing to the use of various peptide concentrations and buffer compositions, the self-assembling peptide hydrogels might be influenced regarding their mechanical characteristics. Therefore, the mechanical properties and stability of a set of self-assembling peptide hydrogels, consisting of 11 amino acids, made from four beta sheet self-assembling peptides in various peptide concentrations and buffer compositions were studied. The formed self-assembling peptide hydrogels exhibited stiffnesses ranging from 0.6 to 205 kPa. The hydrogel stiffness was mostly affected by peptide sequence followed by peptide concentration and buffer composition. All self-assembling peptide hydrogels examined provided a nanofibrillar network formation. A maximum self-assembling peptide hydrogel dissolution of 20% was observed for different buffer solutions after 7 days. The stability regarding enzymatic and bacterial digestion showed less degradation in comparison to the self-assembling peptide hydrogel dissolution rate in buffer. The tested set of self-assembling peptide hydrogels were able to form stable scaffolds and provided a broad spectrum of tissue-specific stiffnesses that are suitable for a regenerative therapy.
Supplementary Information from Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition
Creators: name: Koch, Franziska
name: Müller, Michael
name: König, Finja
name: Meyer, Nina
name: Gattlen, Jasmin
name: Pieles, Uwe
name: Peters, Kirsten
name: Kreikemeyer, Bernd
name: Mathes, Stephanie
name: Saxer, Sina
Publisher: name: The Royal Society
Year: 2018

description: Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and nanofibrillar structure. Thus, self-assembling peptide hydrogels might be suitable scaffolds for regenerative therapies and tissue engineering. Owing to the use of various peptide concentrations and buffer compositions, the self-assembling peptide hydrogels might be influenced regarding their mechanical characteristics. Therefore, the mechanical properties and stability of a set of self-assembling peptide hydrogels, consisting of 11 amino acids, made from four beta sheet self-assembling peptides in various peptide concentrations and buffer compositions were studied. The formed self-assembling peptide hydrogels exhibited stiffnesses ranging from 0.6 to 205 kPa. The hydrogel stiffness was mostly affected by peptide sequence followed by peptide concentration and buffer composition. All self-assembling peptide hydrogels examined provided a nanofibrillar network formation. A maximum self-assembling peptide hydrogel dissolution of 20% was observed for different buffer solutions after 7 days. The stability regarding enzymatic and bacterial digestion showed less degradation in comparison to the self-assembling peptide hydrogel dissolution rate in buffer. The tested set of self-assembling peptide hydrogels were able to form stable scaffolds and provided a broad spectrum of tissue-specific stiffnesses that are suitable for a regenerative therapy.
Additional file 1 of Fighting the waves; Covid-19 family life interference in a neurodevelopmental disorder-caregiver population
Creators: name: Nylén-Eriksen, Mats
name: Lara-Cabrera, Mariela Loreto
name: Grov, Ellen Karine
name: Skarsvaag, Hanne
name: Lie, Irene
name: Dahl-Michelsen, Tone
name: Sæterstrand, Torill Margaret
name: Mandahl, Arthur
name: Hafstad, Hege
name: Lersveen, Mona Breding
name: Bjørnnes, Ann Kristin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary table. Correlation matrix of independent variables - Checking for multicollinearity.
title: The broken triangle: women’s gender based oppression, community development and the promotion of women’s health and wellbeing in Ireland
Creators: name: Doherty, Rosalie
Publisher: name: University of Glasgow
Year: 2019

description: The starting point for this study were the challenges I experienced in my efforts to develop a feminist approach to the promotion of women’s health in Ireland. This approach, informed by a social determinants model of health identifies gender as a determinant of women’s health and wellbeing and as a socially constructed social injustice. I argue that, as a social justice issue, gender as a determinant of women’s health and wellbeing should be addressed by those avowing a social justice agenda. The research questions are explored with community development practitioners in the Republic of Ireland. My position is based on personal experience of living as a woman in Ireland and working for almost a decade as a women’s health officer in the Irish health services, principally in health promotion. The ‘Broken triangle’ of the title of this study refers to the damaging disconnect which I argue exists between the three constituent elements, women’s gender based oppression, community development and the promotion of women’s health and wellbeing. In theory the elements should fit neatly together as a joint framework for professional action. In reality there are a number of obstacles preventing the connection of the different elements which is necessary for the operationalising of the framework. One of the obstacles is the inclination of both health promotion and community development, despite the rhetoric, to maintain professional separateness. Building healthy communities is recognised universally as a goal of community development and efforts to achieve this goal are informed by such principles as social justice, empowerment and respect. Theory relating to the promotion of health extends the understanding of health to include wellbeing and mental and emotional health and recognises the impact and importance of social and cultural factors as determinants of health. I explore some of the reasons for this lack of connection between community development and health promotion. The principal barrier to fixing the triangle identified in my argument is the absence of a feminist analysis in community development and in health promotion. Feminism in professional practice, particularly in community development, is not an issue that has received much attention. Nearly forty years after Wilson’s call to ‘inject some feminism into community development’ (Wilson, 1997) Emejulu and Bronstein (2011) conclude that feminist community development is still in a precarious position’ (Emejulu and Bronstein, 2011, p.283). Using a feminist postcolonial analysis I explore the particular challenges presented by the patriarchal culture in Ireland, including a level of accommodation and denial by practitioners themselves.
title: What went wrong for Quilliam: an investigative analysis of the Quilliam Foundation and the reasons behind its apparent failure
Creators: name: Johnson, Amy M.
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Quilliam.

description: The thesis undertakes an investigative analysis of the Quilliam Foundation, the world’s first counter extremism think tank. A strong opponent of Islamist ideology in its battle against extremism, since its formation Quilliam has attracted growing criticism. The thesis traces the reasons behind this criticism in order to answer the question posed - what went wrong for Quilliam? Issues of unsound theory, the influencing of government, the support of the Prevent policy and a series of public relations disasters has caused Quilliam to alienate the very people it needs to work alongside. Its actions have caused it to be mistrusted and to be deemed out of touch with what it mean to be Muslim in modern Britain.
Additional file 1 of Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study
Creators: name: Ayyagari, Vijayalakshmi
name: Li, Maio
name: Pasman, Zvi
name: Wang, Xinjia
name: Louis, Somaja
name: Diaz-Sylvester, Paula
name: Groesch, Kathleen
name: Wilson, Teresa
name: Brard, Laurent
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Inorganic Chemistry

description: Additional file 1: Supplementary Table 1. Ovarian Cancer - PrognoscanOnline Platform Analysis. Supplementary Figure 1. Kaplan-Meier Plotter Analysis. Overall survival curves for SOAT1 (221561_at) were obtained for Ovarian Cancer patients divided into two groups as low-expression and high-expression based on the optimal cut-off value for survival. Information was obtained from the public database available at https://kmplot.com/analysis/ . Supplementary Figure 2. The Cancer Genome Atlas (TCGA) Analysis. 5-year survival curves for Ovarian Cancer patients divided into two groups (low vs. high ACAT1 expression) based on the optimal cut-off value for survival. Information was obtained from the public database available at https://www.proteinatlas.org . Supplementary Figure 3. cBioPortaldatabase analysis. Overall survival curves for Ovarian Cancer patients divided into different ACAT1 gene expression groups based on quartiles. Information was obtained from the public database available at https://www.cbioportal.org .
Chemical structures, MS spectra, 1H-NMR spectra, HPLC spectra and the antifungal effect of compounds or drugs. from Amphotericin B-conjugated poly-peptide hydrogels as a novel innovative strategy for fungal infections
Creators: name: Shu, Chang
name: Li, Tengfei
name: Yang, Wen
name: Li, Duo
name: Ji, Shunli
name: Ding, Li
Publisher: name: The Royal Society
Year: 2018

description: Chemical structures, MS spectra, and 1H-NMR spectra of compounds. The HPLC spectra of AmB and Dex drugs. The antifungal effect of AmB and AmB-conjugated hydrogels were tested against Candida albicans.
SI for Royal-Society-Open-Science-submitted-20171115 from Unexpected solvent effects on the UV/Vis absorption spectra of o-cresol in toluene and benzene: in contrast with non-aromatic solvents
Creators: name: Zheng, Dong
name: Yuan, Xiang-Ai
name: Ma, Haibo
name: Li, Xiaoxiong
name: Wang, Xizhang
name: Liu, Ziteng
name: Ma, Jing
Publisher: name: The Royal Society
Year: 2018

description: Cresol is a prototype molecule in understanding intermolecular interactions in material and biological systems, because it offers different binding sites with various solvents and protonation states under different pH values. It is remarkable to find that the UV/Vis absorption spectra of o-cresol in aromatic solvents (benzene, toluene) are featured by a sharp peak, unlike the broad double-peaks in 11 non-aromatic solvents. Both molecular dynamics simulations and electronic structure calculations revealed the formation of intermolecular π-complexation between o-cresol and aromatic solvents. The solvent and thermal movements render the conformations of o-cresol changing between trans and cis isomers. The π-interaction makes the cis configuration a dominant isomer, hence leading to the single keen-edged UV/Vis absorption peak at approximately 283 nm. The free conformation changes between trans and cis in aqueous solution rationalize the broader absorption peaks in the range of 260–280 nm. The pH dependence of the UV/Vis absorption spectra in aqueous solutions is also rationalized by different protonation states of o-cresol. The explicit solvent model with long-ranged interactions is vital to describe the effects of π-complexation and electrostatic interaction on the UV/Vis absorption spectra of o-cresol in toluene and alkaline aqueous (pH > 10.3) solutions, respectively.