cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Biogeochemical Examination of Ontario’s Boreal Forest Ecosite Classification System
Creators: name: Tamminga, Aaron
name: Scott, Neal A.
name: Treitz, Paul
name: Woods, Murray
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The ecosite unit in Ontario’s boreal forest ecological land classification system is a polygon of common vegetation type and soil conditions intended to provide a standardized provincial framework to inform meso-scale forestry and planning applications. To determine whether the physical factors used for ecosite classification relate to patterns in ecological function over finer spatial scales, we examined 14 soil properties in replicate boreal forest plots representing eight mineral soil ecosite classes and three organic soil ecosite classes in the Hearst Forest. Despite large differences in vegetation composition, we found few statistically significant differences in properties when compared for individual classes or for more general groupings based on vegetation type and soil texture or expected fertility status. However, some properties (soil organic carbon, total nitrogen, and C:N ratio) were approaching significance in the 0–10 cm depth increment, and there were distinct differences between organic soil and mineral soil sites. Overall, these results suggest few explicit links between ecosystem function and ecosite class at this scale of measurement, highlighting the potential importance of non-steady-state relationships between vegetation species and soil properties in disturbed forests and the potential need for finer-scale characterization to capture patterns in ecosystem function.
title: Das Loyalitätsverhalten von Firmenkunden im Corporate Banking
Creators: name: Kapeller, Alexander
Publisher: name: University of Bayreuth
Year: 2020
Subjects: subject: Loyalität
subject: Firmenkunden
subject: B2B
subject: Bank
subject: Dienstleistung
subject: Service Dominant Logic
subject: 330

description: Die Frage, wie sich das Loyalitätsverhalten von Firmenkunden im Corporate Banking im Kontext der Beziehungsdyade zu Bank und Kundenberater entwickelt, steht im Mittelpunkt der Arbeit. Auch die entsprechenden Größenunterschiede der Firmenkunden werden betrachtet. Zur Beantwortung der Forschungsfragen wird ein Loyalitätsmodell entwickelt und mittels der Service Dominant Logic über die Ebenen Bank und Kundenberater projeziert. Die empirische Untersuchung wird mittels Strukturgleichungsmodell durchgeführt. Es zeigt sich, dass die Entwicklung der Loyalität zum Kundenberater keine Durchgängigkeit bis hin zur Verhaltensloyalität aufzeigt. Dies ist bei der Loyalität zur Bank hingegen der Fall, jedoch nur für kleinere Firmenkunden. Die Unternehmensgröße zeigt generell einen starken negativen Einfluss auf die Verhaltensloyalität.
Wechsler, Mayer
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1829

description: Ort: Memmingen
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Verwaltungsrat Protokollbuch 5
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1956

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Verwaltungsrat Protokollbuch 4
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1948

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Verwaltungsrat Protokollbuch 3
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1939

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
74 Briefe Hans Georg Nägelis an Breitkopf & Härtel in Leipzig
Creators: name: Nägeli, Hans Georg
name: Refardt, Edgar
Publisher: name: [s.n.]
Year: 1793

description: Im Besitze der Firma Breitkopf & Härtel kopiert nach den Originalen im Mai 1930 von Edgar Refardt
description: Briefe ohne verbindenden Text
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Juni 2024 HAN-Katalogisierungsregeln Revision nach Vorlage ben
Abrégé de la science du salut
Discours theologiques auxquels l'on explique netement tout ce qu'il faut croire et tout ce qu'il faut pratiquer pour estre sauvé
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1692

description: Auf Bl. 80v, 110r und 211r sind kleine kolorierte Holzschnitte mit verschiedenen Sujets eingeklebt; auf Bl. 24r, 154r, 164v und 277r sind ebensolche herausgeschnitten worden.
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Jan. 2010 Titel, Jahr und Signatur nach: Steinmann, unpublizierte Beschreibung
description: Verzeichnung=Description=Inventaire Nov. 2014 HAN-Katalogisierungsregeln Minimalaufnahme nach: Steinmann, unpublizierte Beschreibung
description: Verzeichnung=Description=Inventaire Juni 2024 HAN-Katalogisierungsregeln Ergänzung der Minimalaufnahme nach Autopsie und Steinmann
description: Digitalisierung=Digitization=Numérisation Juni 2024 TIFF
description: Erschliessungsniveau Minimalniveau
Understanding the role of the shha-expressing cells during zebrafish caudal fin regeneration
Creators: name: Jeradi, Shirine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Molecular.

description: Zebrafish is able to regenerate its fins following amputation. We are interested in elucidating the cellular and molecular events that are underlying regeneration of the bones of the fin rays. Previous studies from our laboratory showed that genes involved in the Hedgehog Hh pathway are re-expressed during fin regeneration. In addition, gain and loss of function experiments previously showed that Hedgehog signalling might be involved in regenerate outgrowth and osteoblasts differentiation and patterning. Two members of the hedgehog gene family are expressed during fin regeneration: ihha (Indian Hedgehog) is expressed in the newly differentiated osteoblasts, while shha (Sonic Hedgehog) is expressed in a small domain of the basal epidermal layer in the differentiation zone. To understand the specific role of the shha-expressing cells, we precisely monitored these cells during the process of branching morphogenesis, using the transgenic line 2.4shha:GFPABC#15. We subsequently defined 3 stages that are successively taking place during the formation of the branches in the regenerating fin ray. We also assessed the expression profile of genes that might be involved in potential cross-talks between HH/FGF signalling during fin ray regeneration. Shh has been shown to play a role during branching morphogenesis in different organs that branche, through inducing cell proliferation. We analysed the cell proliferation profile during branching morphogenesis in the regenerating fin rays, and we suggest that shha-expressing cells might regulate the proliferation rate during branching morphogenesis. Previous results obtained from laser ablation experiments, where the transgenic line 2.4shha:gfp:ABC#15 was used to specifically but transiently ablate the shha-expressing cells using a laser beam showed that the transient absence of the shha --expressing cells from the regenerating ray results in a branching delay. Based on this finding, along with our results from cell proliferation analysis, and the time course analysis of the shha --expressing cells during branching morphogenesis, we propose a model for branches formation during fin regeneration, in which the splitting of shha ---expressing cells govern branches formation. We also elaborated a new approach based on the generation of a transgenic line expressing the nitroreductase in the shha-expressing cells, through which we aim to conditionally ablate these cells in the fin regenerate by addition of the prodrug, metronidazole. This will allow us to maintain the absence the shh-expressing cells long enough to observe the long term ablation effects and to better understand the role of these cells during caudal fin regeneration.
Studies toward the total synthesis of (+-)-agelasimine A and its analogs, and development of the tandem oxy-copeeneClaisen reaction
Creators: name: Denissova, Irina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Chemistry, Organic.

description: The discovery and development of a novel tandem oxy-Cope/ene/Claisen reaction is described. The strategy allows for highly diastereoselective formation of trans-decalins having a quaternary carbon center at C9. Depending on the substitution pattern of the terminal olefin of the starting 1,2-divinylcyclohexanol an additional tertiary or quaternary carbon center can be introduced at C11.* The oxy-Cope/ene/Claisen reaction of 1,2-divinylcyclohexanol propargyl ethers provides decalines possessing an allene moiety.* An approach toward the total synthesis of (+/-)-agelasimine A, a clerodane-related diterpene isolated from orange sponge Agelas mauritiana , via the oxy-Cope/ene and the oxy-Cope/ene/Claisen reaction has been investigated.* The factors affecting the selectivity at C8 during the oxy-Cope/ene reaction have been studied in detail. Control over the selectivity at C8 can be achieved by either increasing the energy difference between transition states of the ene-reaction or changing the electronic properties of the substituent a to the carbonyl.* The new approach toward formation of the quaternary carbon centers via an anionic oxy-Cope/alkylation reaction is also described. The anionic oxy-Cope reaction affords the macrocyclic enolate, which geometry is predetermined by the stereochemistry of the starting material and a chair-like transition state of the oxy-Cope reaction. The conformation of the macrocycle provides excellent means for controlling facial approach of the electrophile in the following alkylation step. Cleavage of the resulting macrocyclic ketone would afford a chiral ester bearing a quaternary carbon center alpha to a carbonyl.* *Please refer to dissertation for diagrams.
Evaluating the e-PASS: the psychometric properties and user experience of an online clinical diagnostic assessment program for mental disorders
Creators: name: Nguyen, David Phong
Publisher: name: Swinburne
Year: 2024

description: Diagnostic assessment is critical for identifying and treating mental disorders. However, consumers face numerous barriers to effective diagnostic assessment in traditional clinical practice, including: stigma and poor mental health literacy; high costs and shortage of clinicians; and inadequate assessment resources and training for clinicians. With recent internet usage growth, web-based diagnostic assessment programs offer a means of overcoming these barriers while also providing benefits such as added accuracy and efficiency through automated item and scoring administration. However, they also raise issues which emphasise the need to ensure such programs are effective. At present, various web-based programs are publically available, although most present limited diagnostic functionality (e.g., narrow scope of disorders, limited feedback) and lack supporting research. This prompted development of the e-PASS, a freely available web-based clinical assessment program providing diagnostic and referral feedback for 21 disorders. To inform its appropriate use and address the dearth of empirical literature regarding similar applications, this thesis reports an evaluation of the e-PASS's performance in real-world circumstances. Participants consisted of Australian adults (N = 616, M age = 38.1 years) recruited online and representing actual e-PASS users. In a psychometric study, participant subsets underwent: a structured clinical interview (n = 158); standardised clinical questionnaires (n = 173); and e-PASS re-testing (n = 39). With the clinical interview as the gold standard, the e-PASS's diagnostic results displayed: strong agreement for some disorders (e.g. panic disorder) but not others (e.g. social phobia, OCD); high specificity, and varying sensitivity; similar or better accuracy compared to certain clinical questionnaires; and limited accuracy in primary diagnosis. Test-retest reliability was found to be high, while logistic regression indicated that reducing the diagnostic threshold and adding particular items could improve e-PASS validity. Two studies evaluated the e-PASS's user experience, with participants (recruited from the psychometric study) completing an online survey (n = 88) or in-depth qualitative interviewing (n = 15). Results showed high e-PASS acceptability, including motivation to re-take the e-PASS for future needs. The e-PASS was widely praised for being more comprehensive and less-judgmental than previous assessment experiences, promoting accessibility, anonymity, self-reflection, and disclosure. Group differences in experiences, as well as criticisms regarding length, restrictive response options, and lack of support in some cases highlighted the need to tailor online assessment to optimise outcomes. In conclusion, the e-PASS clearly demonstrates the potential to enhance traditional clinical assessment practice, and improve consumer mental health awareness and access to appropriate services.
From Cmv1 to Ly49h: Molecular genetics, haplotype analysis and transgenesis to characterize innate immunity to cytomegalovirus
Creators: name: Lee, Seung-Hwan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Genetics.

description: In mice, natural resistance to infection with murine cytomegalovirus (MCMV) is controlled by a dominant chromosome 6 locus, Cmv1, which is expressed at the level of Natural killer (NK) cells. To characterize the molecular mechanism underlying MCMV-resistance, our laboratory initiated a positional cloning approach for the identification of Cmv1, and localized the host resistance locus to a 0.35 cM genetic interval, corresponding to 1.6 Mb genomic DNA. This dissertation presents the results leading to the cloning and characterization of the Cmv1 gene. First, I constructed a transcription map for the Cmv1 interval, which included 19 genes comprising the full Ly49 gene cluster and other novel candidate genes. In an attempt to narrow down the localization of Cmv1, I determined haplotypes in the vicinity of the Cmv1 interval in a panel of 17 inbred mice strains. This approach demonstrated the presence of three major classes of independent haplotypes. Close inspection of allele sharing among those haplotypes excluded Ly49e, Ly49f and Ly49d as Cmv1 candidates. As an alternative approach to cloning Cmv1, I took advantage of a recombinant inbred strain, the BXD-8 strain. The BXD-8 line was of particular interest because it is susceptible to MCMV infection while harboring an MCMV-resistance C57BL/6 haplotype at Cmv1. Using STS content and PFGE analysis, I showed the presence of a 23 kb deletion in BXD-8. Subsequent gene expression analysis of the full Ly49 gene cluster revealed that the deletion of Ly49h is associated with MCMV susceptibility in BXD-8 mice. Finally, to test the role of Ly49h in host resistance to MCMV infection, I introduced the Ly49h gene into a susceptible background. Investigation of Ly49h gene expression by RT-PCR and FRCS analysis demonstrated a strong correlation between the level of Ly49h mRNA and protein expression and the control of MCMV replication, providing conclusive evidence of the allelism between Cmv1 and Ly49h. In conclusion, I identified the Ly49h gene encoding a NK activation receptor as Cmv1 supporting a specific role for NK cells in antiviral immunity. Transgenic mice expressing Ly49H will be instrumental for understanding of mechanism of NK mediated resistance and possible pleiotropic effects of Cmv1.
BioExcel Webinar #45 - PDB-Dev: A prototype system for archiving integrative structures
Creators: name: Vallat, Brinda
name: Webb, Benjamin
Publisher: name: Zenodo
Year: 2020
Subjects: webinar

description: PDB-Dev is a prototype system for archiving structures of biological macromolecules determined using integrative modeling methods. Integrative modeling combines spatial restraints derived from a variety of biophysical techniques to determine the three dimensional structures of complex macromolecular assemblies. In addition, structures determined using integrative modeling can comprise of diverse spatio-temporal scales and conformational states, which pose unique challenges for data archiving. This talk will focus on recent developments including the creation of data standards and building the foundational infrastructure required for archiving integrative structures.
Effects of Peroxisome Proliferator-Activated Receptor Ligands on the Hypothalamic-Pituitary-Gonadal Axis of the Male Goldfish
Creators: name: Cameron, Colin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Endocrinology.

description: Fibrate pharmaceuticals are peroxisome proliferator-activated receptor alpha (PPARalpha) ligands that are detected in sewage treatment plant effluents, surface water and groundwater. In a previous study, male goldfish ( Carassius auratus) exposed to the fibrate gemfibrozil (GEM) in the water exhibited decreased plasma testosterone concentrations. The following studies investigate the effects of GEM and other PPAR ligands on components of the hypothalamic-pituitary-gonadal axis of the male goldfish; the pituitary and testes. In vitro cultures of dispersed goldfish pituitary cells and testis fragments were employed to study these two tissues in isolation. The secretion of neither luteinizing hormone nor growth hormone from pituitary cells was affected in a manner that could explain decreases in circulating testosterone. Testosterone synthesis in testis fragments stimulated with human chorionic gonadotropin (hCG) was suppressed following treatment with GEM. This inhibition appeared to be the result of impaired mitochondrial cholesterol transport. However, changes in the expression of two proteins important for mitochondrial cholesterol transport, steroidogenic acute regulatory protein and peripheral benzodiazepine receptor, were not affected by GEM treatment. Investigations on the involvement of extracellular-regulated signal kinase 1/2 (ERK 1/2) in the steroidogenic pathway revealed that phosphorylated ERK 1/2 (P-ERK 1/2) is required for hCG-stimulated testosterone synthesis and that GEM treatment decreased levels of P-ERK 1/2 in the mitochondria of this tissue. The main conclusions from these studies include the following: (1) The effect of waterborne GEM on the HPG axis of the goldfish is a direct effect on the testis, (2) GEM impairs mitochondrial cholesterol transport in the goldfish testis, (3) Phospho-ERK 1/2 is required for hCG-stimulated steroidogenesis in the goldfish testis, and (4) the proposed mechanism by which GEM impairs mitochondrial cholesterol transport is through a reduction in mitochondrial phospho-ERK 1/2.
Test of CP-invariance of the Higgs boson in vector-boson fusion production and its decay into four leptons
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for CP violation in the decay kinematics and vector-boson production of the Higgs boson is performed in the $H \to ZZ^{*} \to 4\ell$ ($\ell = e,μ$) decay channel. The results are based on proton-proton collision data produced at the LHC at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector from 2015 to 2018, corresponding to an integrated luminosity of 139 $\mbox{fb\(^{-1}\)}$. Matrix element-based optimal observables are used to constrain CP-odd couplings beyond the Standard Model in the framework of Standard Model effective field theory expressed in the Warsaw and Higgs bases. Differential fiducial cross-section measurements of the optimal observables are also performed, and a new fiducial cross-section measurement for vector-boson-fusion production is provided. All measurements are in agreement with the Standard Model prediction of a CP-even Higgs boson.
description: 66 pages in total, author list starting page 49, 17 figures, 6 tables, published in JHEP. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2018-30/
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
Creators: name: Wiegand, Kimberly C.
name: Hennessy, Bryan T.
name: Leung, Samuel
name: Wang, Yemin
name: Ju, Zhenlin
name: McGahren, Mollianne
name: Kalloger, Steve
name: Finlayson, Sarah
name: Stemke-Hale, Katherine
name: Lu, Yiling
name: Zhang, Fan
name: Anglesio, Michael
name: Gilks, C. Blake
name: Mills, Gordon B.
name: Huntsman, David G.
name: Carey, M. S.
Publisher: name: BioMed Central
Year: 2016

description: Background: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC and CCC. Methods: Immunohistochemistry (IHC) for BAF250a expression was performed on 127 chemotherapy-naive ovarian carcinomas (33 CCC, 29 EC, and 65 high-grade serous ovarian carcinomas (HGSC)). Whole tumor lysates were prepared from frozen banked tumor samples and profiled by RPPA using 116 antibodies. ARID1A mutations were identified by exome sequencing, and PIK3CA mutations were characterized by MALDI-TOF mass spectrometry. SAM (Significance Analysis of Microarrays) was performed to determine differential protein expression by histological subtype and ARID1A mutation status. Multivariate logistic regression was used to assess the impact of ARID1A mutation status/BAF250a expression on AKT phosphorylation (pAKT). PIK3CA mutation type and PTEN expression were included in the model. BAF250a knockdown was performed in 3 clear cell lines using siRNA to ARID1A. Results: Marked differences in protein expression were observed that are driven by histotype. Compared to HGSC, SAM identified over 50 proteins that are differentially expressed in CCC and EC. These included PI3K/AKT pathway proteins, those regulating the cell cycle, apoptosis, transcription, and other signaling pathways including steroid hormone signaling. Multivariate models showed that tumors with loss of BAF250a expression showed significantly higher levels of AKT-Thr308 and AKT-Ser473 phosphorylation (p < 0.05). In 31 CCC cases, pAKT was similarly significantly increased in tumors with BAF250a loss on IHC. Knockdown of BAF250a by siRNA in three CCC cell lines wild type for ARID1A showed no increase in either pAKT-Thr308 or pAKT-S473 suggesting that pAKT in tumor tissues is indirectly regulated by BAF250a expression. Conclusions: Proteomic assessment of CCC and EC demonstrates remarkable differences in protein expression that are dependent on histotype, thereby further characterizing these cancers. AKT phosphorylation is associated with ARID1A/BAF250a deficient tumors, however in ovarian cancers the mechanism remains to be elucidated.
Methylmercury uptake and bioconcentration by the freshwater green alga Pseudokirchineriella subcapitata
Creators: name: Nwobu, Ogochukwu L
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Ecology.
subject: Environmental Sciences.
subject: Agriculture, Fisheries and Aquaculture.

description: Methylmercury (MeHg) enters most aquatic food webs primarily at the phytoplankton level. However, in the complex aquatic ecosystem, it is difficult to fully examine specific pathways. Consequently, in this study, the uptake of environmentally realistic levels of added MeHg concentrations (0.21 to 20 ng Hg L-1 ) by the freshwater green alga Pseudokirchniriella subcapitata grown in batch and semi-continuous cultures at biomass levels of (0.03, 0.15, 0.3 and 3 mg (dw) L-1) was investigated. In algal culture media without dissolved organic carbon (DOC) and in river water samples with DOC concentration of (2.8 mg L-1) uptake, uptake rate constant, algal concentration of MeHg and the bioconcentration factor (BCF) after 48 h was measured. MeHg uptake was biphasic, with rapid uptake of at least 50% of the total uptake taking place over the first 2 h of incubation followed by a more gradual uptake for the remaining 46 h. Desorption of MeHg from algal cells by re-suspension in acidic medium (pH 3) was < 10% of the total uptake at 48 h. Uptake rate constants of MeHg (ku) increased with aqueous MeHg concentration (r2 = 0.99). At 48 h, algal concentration of MeHg (MeHg (ng) divided by dry weight of algal biomass (g)) increased with aqueous MeHg concentration (r2 = 0.98) but decreased with increasing biomass (r2 = 0.75). This was shown to be a biomass dilution effect as the total uptake of MeHg did increase with biomass. Log MeHg BCF decreased with increasing algal biomass (r 2 = 0.99) with values of 6.9, 6.2 and 5.2 at 0.03, 0.3 and 3 mg (dw) L-1 respectively at all concentrations of MeHg added (0.5, 1.0 and 20 ng L-1).
The mechanism by which protein elongation factor eEF1A2 enhances cell growth and oncogenicity
Creators: name: Kulkarni, Geeta
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Cell.
subject: Health Sciences, Immunology.

description: EEF1A2 is a putative ovarian and breast oncogene that encodes protein elongation factor eEF1A2. During protein translation, eEF1A2 binds amino-acylated tRNA and recruits it to the ribosome. eEF1A2 also regulates the translocation of the growing polypeptide from the acceptor (A) site to the peptidyl (P) site of the ribosome. Human EEF1A2 is one of two isoforms of eukaryotic elongation factor 1alpha(EEF1A). EEF1A1 and EEF1A2 share more than 90% DNA and amino acid sequence homology. eEF1A proteins from several species and genera associate with the cellular actin network by binding actin filaments and depolymerizing alpha-tubulin microtubules. This suggests that eEF1A proteins may contribute to the regulation of cytoskeletal organization in addition to controlling protein translation. EEF1A2 is increased in copy number in about 25% of primary ovarian tumors and highly expressed in approximately 30% of ovarian tumors and established cell lines. (Abstract shortened by UMI.)
Erreurs judiciaires: Le rôle des interrogatoires policiers dans la production de faux aveux
Creators: name: Héroux, Mélanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Sociology, Criminology and Penology.

description: La présente recherche a pour objet de comprendre le rôle des interrogatoires policiers dans la production de faux aveux au Canada. Nous cherchons ainsi de possibles liens entre des individus qui avouent faussement des crimes et les interrogatoires dont ils ont fait l'objet. La méthodologie adoptée pour sa réalisation est de type qualitative, composée d'entretiens avec des personnes qui ont fait de faux aveux et d'enquêteurs, d'une analyse documentaire ainsi que d'une revue de littérature. Notre objet de recherche n'ayant pas été encore étudié au Canada, nous avons été dans l'obligation de nous référer à divers sujets venant des États-Unis ainsi que de manuels et recherches provenant également des États-Unis, mais aussi de l'Europe et du Royaume-Uni. Il nous aurait été très difficile de comprendre adéquatement notre objet de recherche sans ces ressources, puisque la littérature canadienne est quasi inexistante. Les résultats des entretiens que nous avons réalisé permettent de mettre en relief diverses pratiques problématiques qui peuvent expliquer la production de faux aveux. À partir des données obtenues, nous démontrerons que les personnes qui ont fait un faux aveu ont subi diverses pressions (psychologiques, physiques ou juridiques) pendant leur interrogatoire. Ce constat est considérable à l'avancement des connaissances puisque le Canada ne possède présentement que quelques données sur ce sujet. La présente recherche, nous l'espérons, permettra ainsi de contribuer à la prévention de faux aveux durant les interrogatoires au Canada.
Le lyrisme dans la poésie de Pierre Morency
Creators: name: Codaire, Émilie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Literature, Modern.
subject: Literature, Canadian (French).

description: Notre thèse consiste à étudier les caractéristiques du lyrisme contemporain dans les cinq premiers recueils de poèmes de Pierre Morency: Poèmes de la froide merveille de vivre (1967), Poèmes de la vie déliée (1968), Au nord constamment de l'amour (1970), Lieu de naissance (1973) et Torrentiel (1978). Ces oeuvres forment un bloc d'environ dix ans d'écriture poétique et se définissent par un lyrisme plus marqué, par comparaison avec la production poétique de Pierre Morency après 1978. Dans un premier temps, nous définirons la spécificité du lyrisme contemporain en France et au Québec. Ensuite, nous analyserons les manifestations du lyrisme dans les cinq recueils du poète. Cette étude nous permettra de saisir l'originalité de la voix lyrique de Pierre Morency, ainsi que son évolution d'un recueil à l'autre. Notre thèse apportera ainsi un éclairage nouveau sur une oeuvre---à tout le moins, sur une partie de celle-ci, la plus significative, selon nous---peu étudiée.
The role of attachment insecurity in symptom presentation, treatment process and treatment outcome in a clinical sample of women with eating disorders
Creators: name: Illing, Vanessa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Psychology, Clinical.

description: The current state of knowledge makes it necessary to consider other theoretical frameworks to account for symptom presentation and treatment outcomes for women with an eating disorder (ED). Attachment theory is a theoretical framework that could playa central role in our understanding and treatment of EDs. This thesis consists of two studies that examine the role of adult attachment in understanding: (1) ED symptom expression and treatment outcome among a sample of women with anorexia nervosa restricting subtype (ANR), AN binge purge subtype (ANB) or bulimia nervosa (BN), and (2) group treatment processes among women with ANR, ANB, BN and eating disorder not otherwise specified (EDNOS) receiving treatment in day hospital group-based program with rolling admissions. In the first study women diagnosed with ANR, ANB, or BN completed an attachment scale pre-treatment, and ED symptom scales pre-treatment (N = 243) and post-treatment (N = 157). A comparison sample of 126 non-ED women completed attachment scales on one occasion. Those with EDs had significantly higher attachment insecurity than non-ED. ANB was associated with higher attachment avoidance compared to ANR and BN, and higher attachment anxiety compared to BN. Higher attachment anxiety was significantly related to greater ED symptom severity and poorer treatment outcome across all EDs even after controlling for ED diagnosis. In the second study women (N= 264) diagnosed with an ED completed attachment scales pre-treatment, ED symptom scales pre- and post-treatment, and group climate scales weekly during treatment. Engaged group climate increased and Avoidance group climate decreased across weeks of treatment. Engaged group climate growth was associated with improved ED symptoms post-treatment. Higher attachment avoidance at pre-treatment was related to lower Engaged group climate at week 1, and was related to a greater impact of the group on the individual's experience of group engagement. Overall, attachment dimensions substantially contribute to our understanding of ED symptoms and treatment outcome. Addressing attachment insecurity when treating those with EDs may improve treatment outcomes. Furthermore, clinicians might improve group processes and outcomes by tailoring interventions to individuals' attachment avoidance when treating women for EDs.
Transient Analysis of Electromagnetic Waves Based on Numerical Inversion of Laplace Transform
Creators: name: Zeng, Qingsheng
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Engineering, Electronics and Electrical.

description: The advancement of electromagnetic engineering has been driving the need to develop efficient techniques for the transient analysis of transmission, propagation and reception of electromagnetic waves in different media. This thesis addresses a new method based on the numerical inversion of Laplace transform (NILT), which overcomes the restrictions in previous approaches, leads to good accuracy in both late and early time, and has simple algorithms, short calculation time and small required memory sizes. To our knowledge, this would be the first time that systematically treats the theory of NILT and its application in the transient analysis of electromagnetic waves. In this thesis, firstly a literature survey is carried out and the weaknesses and limitations of some current time domain techniques are identified. Then Hosono's algorithm for the NILT is treated and developed under a strict theoretical framework. Next, this new technique based on NILT is employed to model the transient reflection of horizontally and vertically polarized waves from a conductive interface with exponentially decaying incident signals. After that, this technique is combined with Prony's method and applied to modeling the transient reflection from a conductive interface and propagation through a lossy dielectric slab with an arbitrary incident signal for both polarizations. Furthermore, this technique is used for the transient analysis of exponentially decaying pulses propagating in plasma with a zero and nonzero electron collision frequency for both polarizations. The technique is extended and applied to the transient anlysis of horizontally and vertically polarized waves reflected from Lorentz, Debye and Cole--Cole half spaces with an arbitrary incident pulse, using the convolution of a time domain reflection coefficients and an incident signal. Finally, based on the transient anlysis of pulses reflected from a dispersive medium half space, the relationships between the waveform parameters of reflected pulses and the properties of dispersive materials as well as the incident angles are discussed, and the application of these results to material characterization and diagnosis is explored. This thesis highlights how to overcome the restriction that numerical inversion of Laplace transform has high demands on image functions, and places the emphasis on how to extend and apply this method to a variety of cases. The correctness and effectiveness of this thesis work are validated through the comparisons between our results and those published in the literature. Meanwhile, the results that cannot be achieved with the previous approaches are also provided. Moreover, this thesis presents some applications of the new technique in diverse engineering fields, including ultra wideband technology and material science.
Domestic Violence in Aboriginal Communities: A Context for Resilience
Creators: name: Olsen Harper, Anita
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Education, Adult and Continuing.
subject: Psychology, Counseling.
subject: Native American Studies.

description: My research is a study of the perspectives of resilience by survivors of domestic violence (DV) in three Aboriginal communities. The Executive Directors (EDs) of the women's shelters on these reserves were interviewed, as well as three DV survivors who were identified by the EDs. The meanings articulated by interviewees is intended to provide educators and those in anti-violence efforts with an increased understanding of resilience as defined by Aboriginal DV survivors. The interpretations that were voiced are different from those that are understood according to prevailing Western tradition. Among Aboriginal populations, internally-derived perspectives of resilience, I contend, are foundational in developing curricula aimed at reducing DV and its traumatic manifestations. DV is often deceptively and simplistically construed as the conduct and dynamics of two people within a home. However, my investigative study that includes a comprehensive literature review, exposes the fallacy of this assumption as it pertains to Aboriginal communities: DV has historic origins that are strongly grounded in colonialism. DV is, as well, socially constructed in power hierarchies that sustain patriarchal supremacy, and a devastating social and psychological plague in all reserve communities. My research recognizes that community-based interventions in Aboriginal communities can only be effectively operationalized with the knowledge of the intricacies of colonialism as they pertain specifically to DV. Drawing on traditional beliefs and community principles such as meaningful participation, integration of cultural and spiritual practices, recognition of historical injustices by colonizing forces, consensus-derived decision-making involving women and youth all help inform educational offerings about the actionable content and delivery of resilience teachings. Keywords: Aboriginal, colonialism, domestic violence, resilience, well-being
The association between "hypertriglyceridemic waist" and sub-clinical atherosclerosis in a multiethnic population: a cross-sectional study
Creators: name: Gasevic, Danijela
name: Carlsson, Axel C.
name: Lesser, Iris A.
name: Mancini, GB J.
name: Lear, Scott A.
Publisher: name: BioMed Central
Year: 2015

description: Background: "Hypertriglyceridemic waist" (HTGW) phenotype, an inexpensive early screening tool for detection of individuals at risk for type 2 diabetes and cardiovascular disease was found to be associated with subclinical atherosclerosis in various patient populations such as those with diabetes mellitus, chronic kidney disease, and those infected with human immunodeficiency virus. However, less is known regarding an association between HTGW and subclinical atherosclerosis in the apparently healthy, multiethnic population. Therefore, the aim of the study was to explore the association between HTGW and sub-clinical atherosclerosis in an apparently healthy, multiethnic population; and to investigate whether the effect of HTGW on sub-clinical atherosclerosis persists over and above the traditional atherosclerosis risk factors. Methods We studied 809 individuals of Aboriginal, Chinese, European and South Asian origin who were assessed for indices of sub-clinical atherosclerosis (intima-media thickness (IMT), total area and presence of carotid plaques), socio-demographic and lifestyle characteristics, anthropometrics, lipids, glucose, blood pressure, and family history of cardiovascular disease. Results We found that, compared to individuals without HTGW and after adjusting for age, ethnicity, smoking, and physical activity; men and women with HTGW had a significantly higher: IMT (men: B (95%CI = 0.084 (0.037, 1.133), p < 0.001; women: B (95%CI) = 0.041 (0.006, 0.077), p = 0.020); and total area (men: B (95%CI = 0.202 (0.058, 0.366), p = 0.005; women: B (95%CI) = 0.115 (0.006, 0.235), p = 0.037). The association between HTGW waist and presence of plaques was significant for men (OR (95%CI) = 1.904 (1.040, 3.486), p = 0.037 vs. men without HTGW), but not for women (p = 0.284). Once analyses were adjusted for additional, traditional risk factors for atherosclerosis, the effect of HTGW on sub-clinical atherosclerosis was no longer significant. Conclusions In conclusion, HTGW may serve as an early marker of subclinical atherosclerosis in men and women, irrespective of ethnicity. However, once individuals are assessed for all traditional risk factors for atherosclerosis, the additional assessment for HTGW is not warranted.
Virus-receptor interactions of Enterovirus 70: Roles of sialic acid and decay-accelerating factor
Creators: name: Alexander, David A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Cell.
subject: Biology, Microbiology.
subject: Chemistry, Biochemistry.

description: The interaction of viruses with host cell receptors is the initial step in viral infection and is an important determinant of virus host range, tissue tropism and pathogenesis. The complement regulatory protein decay-accelerating factor (DAF/CD55) is an attachment receptor for Enterovirus 70 (EV70), a member of the family Picornaviridae commonly associated with an eye infection in humans known as acute hemorrhagic conjunctivitis. In earlier work, the EV70 receptor on erythrocytes responsible for viral hemagglutinating activity was shown to be sensitive to neuraminidase, implying an essential role for sialic acid in virus attachment. Here, these findings are extended to show that cell surface sialic acid is required for EV70 binding to nucleated cells susceptible to virus infection, and that sialic acid binding is important in productive infection. Through the use of site-directed mutagenesis to eliminate the single N-linked glycosylation site of DAF and of a chimeric receptor protein in which the O-glycosylated domain of DAF was replaced by a region of the HLA-B44 molecule, a role in EV70 binding for the sialic acid residues of DAF was excluded, suggesting the existence of at least one additional, sialylated EV70-binding factor at the cell surface. Treatment of cells with metabolic inhibitors of glycosylation excluded a role for the N-linked oligosaccharides of glycoproteins, but suggested that O-linked glycosylation is important for EV70 binding. Finally, the virus-receptor interactions of EV70 in physiologically relevant human corneal cell lines and tissue were investigated. Sialic acid, but not DAF, was found to be an essential component of the EV70 receptor on ocular cells. These results provide proof of principle for the novel application of human corneal equivalents as a model system for infections of the eye.
The role of apoptosis in a BMPR2 mutant model of pulmonary arterial hypertension
Creators: name: Yelle, Dominique
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Molecular.

description: Pulmonary arterial hypertension (PAH) is a rare and fatal disease caused by excessive remodelling of small pulmonary arterioles. Heterozygous loss-of-function mutations in the bone morphogenetic protein receptor 2 (BMPR2) have recently been identified in a large portion of patients with familial and idiopathic PAH. However, how mutations in this ubiquitously expressed receptor result in such a specific abnormality of the lung microcirculation is unknown. We hypothesized that loss-of-function mutations in BMPR2 lead to PAH by increasing the susceptibility of ECs to apoptosis, particularly within fragile pulmonary arterioles. To examine the consequences of BMPR2 mutations on the development of PAH, we generated mice that ubiquitously over-express an arginine to stop mutation in the receptor's C-terminal domain (BMPR2 R899X) Characterization of these mice revealed a significant increase in right ventricular systolic pressure, an indicator of pulmonary pressure, which was associated with muscularization of small pulmonary arterioles, alveolar septal thickening and pulmonary macrophage infiltration. In addition, a modest increase in apoptosis was detected in these mice. These data suggest that BMPR2 loss-of-function mutations increase the susceptibility of ECs to apoptosis and set the stage for excessive inflammation, possibly leading to spontaneous PAH. This new model will help elucidate the pathophysiological events leading to the development of PAH and provide a unique tool to evaluate novel potential treatments for this disease.
title: s' Paradies
Creators: name: Riff, Jean
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022

description: TEI version for play in Alsatian. Play subtitle: E luschdigs Schwänkele in aam Uffzug von Jean Riff
Du huis clos au roman: Paroles carcérales et concentrationnaires dans le cadre de la littérature contemporaine
Creators: name: Delorme, Julie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Literature, Canadian (French).

description: Le huis clos, phénomène tout d'abord rattaché à l'espace, se présente replié sur lui-même, entièrement assujetti à l'enfermement, son premier moteur. Cette recherche le conçoit comme un haut lieu d'intensités où toutes les ouvertures débouchent sur le Même. C'est donc à partir du Soi qu'il cherche à transformer autrui. Or, sa force d'altération est d'autant plus forte qu'elle réclame la parole littéraire (c'est d'ailleurs l'enjeu fondamental de cette thèse) comme seule voi(x)e de sortie. Dans l'impossibilité d'interroger toutes les figures du huis clos, la prison et le camp de concentration ont été choisis afin de comprendre les différentes logiques inhérentes aux liens entre la littérature et l'enfermement. Dans l'espace même ou la parole est censée perdre sa liberté, il arrive qu'elle remplisse les conditions lui permettant de développer sa force de représentation, voire son pouvoir de subversion. C'est ce paradoxe sous-jacent au rapport entre le huis clos et la parole littéraire que cette thèse vise à mettre en lumière. L'oeuvre du marquis de Sade servira ici de point de repère. Alors qu'il était incarcéré, l'auteur des Cent vingt journées de Sodome n'a jamais cessé d'écrire afin de libérer l'imaginaire, et ce, jusqu'à toucher les limites de la représentation. Par la suite, cette recherche étudie les stratégies discursives auxquelles fait appel la parole littéraire dans le but de représenter la prison et le camp de concentration dans la fiction romanesque (Camus, Puig, Nothomb, Littell). Aussi ce travail entend-il déterminer les conditions de possibilité des paroles carcérales (Arenas, Liscano, Gagnon) et concentrationnaires (Wiesel, Semprun, Gray) dans la littérature contemporaine.
Vehemence and Victims: Using generic lexicons to investigate emotions in historical Dutch parliamentary debates on war victim legislation (1945-1990)
Creators: name: Lange, Milan Van
name: Futselaar, Ralf
Publisher: name: Zenodo
Year: 2020
Subjects: emotion mining
parliamentary history
history of emotions
digital history

description: This working paper analyses digitized historical parliamentary debates on post-war welfare legislation for victims of the German occupation of the Netherlands. We confront a well-researched historical case with an additional, computational approach. This case also allows us to explore and evaluate the use of generic emotion lexicons in an innovative approach to historical research.