cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Challenges in implementation of public policies in aging and dementia in Peru
Creators: name: Pintado-Caipa, Maritza
name: Diaz, Monica M.
name: Garcia, Patricia J.
Publisher: name: Public Library of Science
Year: 2023

description: Due to population aging and health transitions, people with dementia in Latin America and Caribbean region (LAC) are expected to increase from 7.8 million in 2013 to over 27 million by 2050. Fragmented healthcare systems in the LAC region make it challenging to provide adequate dementia care. However, implementing preventive interventions to reduce the burden of dementia can help strengthen services for aging populations. It is crucial to establish public policies that allocate governmental resources to implement these strategies.
Symmetry reduction of turbulent pipe flows
Creators: name: Fedele, Francesco
name: Abessi, Ozeair
name: Roberts, Philip
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We propose and apply a Fourier-based symmetry reduction scheme to remove, or quotient, the streamwise translation symmetry of Laser-Induced-Fluorescence measurements of turbulent pipe flows that are viewed as dynamical systems in a high-dimensional state space. We also explain the relation between Taylor's hypothesis and the comoving frame velocity $U_{d}$ of the turbulent orbit in state space. In particular, in physical space we observe flow structures that deform as they advect downstream at a speed that differs significantly from $U_{d}$. Indeed, the symmetry reduction analysis of planar dye concentration fields at Reynolds number $\mathfrak{\mathsf{Re}}=3200$ reveals that the speed $u$ at which high concentration peaks advect is roughly 1.43 times $U_{d}$. In a physically meaningful symmetry-reduced frame, the excess speed $u-U_{d}\approx0.43U_{d}$ can be explained in terms of the so-called geometric phase velocity $U_{g}$ associated with the orbit in state space. The 'self-propulsion velocity' $U_{g}$ is induced by the shape-changing dynamics of passive scalar structures observed in the symmetry-reduced frame, in analogy with that of a swimmer at low Reynolds numbers.
description: arXiv admin note: substantial text overlap with arXiv:1407.7487
Citrullination of α2-antiplasmin is unlikely to contribute to enhanced plasmin generation in COVID-19 pathophysiology
Creators: name: Wolberg A.S.
name: Tilvawala R.
name: Flick M.J.
name: Campbell R.A.
name: Kangro K.
Publisher: name: Elsevier B.V.
Year: 2023

description: COVID-19 is caused by the SARS-CoV-2. Severe COVID-19 is characterized by immune cell activation, leading to inflammation and the formation of neutrophil extracellular traps (NETs). COVID-19 is also associated with an imbalance in coagulation and fibrinolytic activity. Exuberant fibrinogen production secondary to the inflammatory response, coupled with elevated thrombin generation, provokes fibrin deposition. However, despite paradoxically increased plasmin generation potential in plasma from patients with COVID-19, fibrinolytic pathways are unable to counter this process. Patients with severe COVID-19 have a high risk of developing venous thromboembolism, and patients with COVID-19 with venous thromboembolism have an increased risk of death.
Effect of the DEF motif on phosphorylation of peptide substrates by ERK
Creators: name: Allbritton, Nancy L.
name: Fernandes, Neychelle
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: MAP kinase ERK maintains specificity by binding to docking sites such as the DEF domain or D domain. It was previously shown that appending peptides derived from D domains to a substrate peptide increased apparent efficiency of peptide phosphorylation while preserving its apparent specificity for ERK. Here we determine the effect of the DEF motif on efficiency and specificity of peptide phosphorylation by ERK. The DEF motif modulated the apparent affinity of the peptide for ERK while the substrate motif dominated the apparent catalytic rate. Attachment of the DEF sequence improved apparent phosphorylation efficiency by 60-fold. Addition of peptides possessing both the DEF and D motif to a substrate sequence did not yield additive effects on the KM of the substrate for ERK. Further, the DEF motif diminished the apparent specificity for ERK and increased the apparent efficiencies of phosphorylation of the substrate peptide by p38α kinase and JNK1.
Comparing typologies of violence exposure and associations with syndemic health outcomes among cisgender and transgender female sex workers living with HIV in the Dominican Republic
Creators: name: Barrington C.
name: Perez M.
name: Rodriguez-Diaz C.
name: MacLin B.J.
name: Kerrigan D.
name: Donastorg Y.
name: Wang Y.
name: Gomez H.
Publisher: name: Public Library of Science
Year: 2023

description: Violence against women research largely excludes transgender women’s experiences and violence from perpetrators other than intimate partners. This study compares patterns of violence exposure among cisgender and transgender female sex workers (FSWs) and the associations with syndemic health outcomes. We used cross-sectional surveys from samples of cisgender and transgender FSWs living with HIV in the Dominican Republic (N = 211 and 100, respectively). We used latent class analysis to identify patterns of emotional, physical and sexual violence and harassment by partners, clients, and police. We assessed sociodemographic and occupational predictors in relation to class membership, and class membership in relation to health (HIV continuum of care outcomes, mental health, substance use), using logistic regression. Two classes were identified in cisgender sample: Low Reported Violence Exposure (Class 1) and Sex Work-related Police Harassment (Class 2). Class 2 participants had greater odds of scoring abnormal or borderline abnormal anxiety on the Hospital Anxiety and Depression Scale (HADS-A) (adjusted OR = 3.97 p<0.01), moderate-to-severe depression per the Patient Health Questionnaire-9 (PHQ-9) (aOR = 5.74, p<0.01), and any illicit drug use in the past six months (aOR = 3.06, p<0.05) compared to Class 1. The transgender sample produced three classes: Low Reported Violence Exposure (Class 1); Sex Work-related Police Harassment (Class 2); and Sex Workrelated Violence and Harassment (Class 3). Class 3 participants had greater odds of having anxiety (aOR = 6.65, p<0.01) and depression (aOR = 4.45, p<0.05), while Class 2 participants had greater odds of perfect ART adherence during the previous four days (aOR = 2.78, p<0.05), compared to Class 1. The more diverse and extreme violence patterns uncovered for the transgender sample show this group’s heightened risk, while similar patterns across groups regarding police abuse highlight a need for police-focused violence prevention interventions. Each sample’s highest violence class was associated with poor mental health, underscoring the need for mental health interventions for all FSWs.
Kasus konsep lahan di desa sei mencirim
Creators: name: Nadia, Putri Ayu
name: Nadia, Putri Ayu
Publisher: name: Zenodo
Year: 2024

description: Kasus ini membahas tentang konfik yang terjadi di desa sei mencirim yaitu tentang sengketa antara masyarakat adat dengan perusahaan perkebunan sawit
Cosmological horizons as new examples of membrane paradigm
Creators: name: Wang, Tower
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we aim to provide new examples of the application and the generality of the membrane paradigm. The membrane paradigm is a formalism for studying the event horizon of black holes. After analyzing it with some technical details and realizing it in the Reissner-Nordstrom black hole, we apply the paradigm to cosmological horizons, firstly to the pure de Sitter horizon, and then to the trapping horizon of the Friedmann-Lemaitre-Robertson-Walker universe. In the latter case, the cosmological stretched horizon is oblique, thus the running of renormalization parameter is nonzero in the timelike direction and gives a correction to the membrane pressure. In this paradigm, the cosmological equations come from continuity equations of the membrane fluid and the bulk fluid respectively.
description: 24 pages, title changed, sect V and appendix enlarged
Complications of Mandibular Distraction Osteogenesis in Infants with Isolated Robin Sequence
Creators: name: Mao, Zhe
name: Ye, Liang
name: Zhou, Jiawei
name: Tian, Gabriel
name: Shrivastava, Mayank
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2023

description: Mandibular Distraction Osteogenesis (MDO) is now the preferred procedure to alleviate airway obstruction in infants with severe Robin Sequence (RS). However, there have been very few studies investigating complications related to MDO surgery performed on patients affected by isolated RS. In this study, age at distraction, weight at distraction, preoperative intubation, repeat MDO and complications associated with MDO were included as variables. Minor, moderate and major problems were evaluated and recorded as surgical site infections (SSI), injuries to the facial nerve, self-extinction hypertrophic scars, temporomandibular joint ankylosis, device failures, early ossification and fibrous non-union. One hundred and fifty one patients with isolated RS were included. At distraction, the mean age was 72 days (12–540 days) and the mean weight was 4.05 kg (2.4–12.2 kg). Only one patient needed tracheostomy after MDO, and none required further distraction. Ultimately, the complication rate was 15.23%, and there was a total of 7.95% minor, 9.27% moderate and 0% major complications. Minor incidents included surgical site infection (SSI) managed with antibiotics taken orally (n = 8), neuropraxia in the VII cranial nerve (CN) (n = 1), and hypertrophic scarring (n = 3). Incidents reported as moderate were SSIs managed with intravenous antibiotics (n = 9), incision and drainage (n = 3) and self-extubation (n = 2). There was no case of TMJ ankylosis. There were no cases of early or premature ossification, fibrous non-union and device fracture. In conclusion, MDO is an effective and appropriate management technique for infants with isolated RS and severe airway obstruction. Infections at the surgery site accounted for the vast majority of the complications. Further investigations may be needed to determine the long-term consequences of MDO.
The ERIЯƎ Theory: Geometrically Restricted Coherence — Interference and the Casimir Effect
Creators: name: DanBrasilP
Publisher: name: GitHub
Year: 2025
Subjects: Quantum Interference
Casimir Effect
ERIRE Theory
Rotational Geometry
Coherent Structures
Phase Resonance
Spatial Constraints
Quantum Foundations

description: This article (Expansion 16 of the ERIЯƎ Theory) presents a unified geometric model that reproduces electron interference and the Casimir effect based on rotational coherence restricted by spatial constraints.

Rather than treating quantum phenomena as inherently probabilistic or reliant on vacuum fluctuations, the ERIЯƎ model interprets them as coherent projections from a higher-dimensional rotational structure. The double-slit experiment is simulated through phase superposition, and the Casimir force arises naturally from differences in mode density between free and confined geometries.

The model yields accurate numerical estimates without postulated constants and suggests that quantum behavior may emerge from geometry and coherence itself.

Source code and simulations: https://github.com/DanBrasilP/ERIRE
description: Este artigo (Expansão 16 da Teoria ERIЯƎ) apresenta um modelo geométrico unificado que reproduz a interferência eletrônica e o efeito Casimir com base na coerência rotacional restrita por restrições espaciais.

Em vez de tratar fenômenos quânticos como inerentemente probabilísticos ou dependentes de flutuações do vácuo, o modelo ERIЯƎ os interpreta como projeções coerentes de uma estrutura rotacional de dimensão superior. O experimento da dupla fenda é simulado por meio de superposição de fases, e a força Casimir surge naturalmente das diferenças na densidade modal entre geometrias livres e confinadas.

O modelo produz estimativas numéricas precisas sem constantes postuladas e sugere que o comportamento quântico pode emergir da geometria e da própria coerência.

Código-fonte e simulações: https://github.com/DanBrasilP/ERIRE
Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells
Creators: name: Bromberg, Philip A.
name: Jaspers, Ilona
name: Peden, David B.
name: Alexis, Neil E.
name: Wu, Weidong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: CD40 plays important roles in cell-mediated and humoral immune responses. In this study, we explored mechanisms underlying lipopolysaccharide (LPS)-induced CD40 expression in purified human peripheral blood monocytic cells (PBMCs) from healthy volunteers. Exposure to LPS induced increases in CD40 mRNA and protein expression on PBMCs. LPS stimulation caused IκBα degradation. Inhibition of NFκB activation abrogated LPS-induced CD40 expression. LPS stimulation also resulted in phosphorylation of mitogen-activated protein kinases, however, only Jun N-terminal kinase (JNK) was partially involved in LPS-induced CD40 expression. In addition, LPS exposure resulted in elevated interferon γ (IFNγ) levels in the medium of PBMCs. Neutralization of IFNγ and IFNγ receptor using specific antibodies blocked LPS-induced CD40 expression by 44% and 37%, respectively. In summary, LPS induced CD40 expression on human PBMCs through activation of NFκB and JNK, and partially through the induction of IFNγproduction.
IPBES Invasive Alien Species Assessment, data management report for Chapter 3. Section 3.2.5: Policies, governance, and institutions
Creators: name: Morales, Carolina L.
Publisher: name: Zenodo
Year: 2023
Subjects: Data management report

description: Section 3.2.5 assesses the role of international institutions and organizations as drivers of biological invasions for chapter 3 of IPBES thematic assessment of invasive alien species and their control. The experts conducted a systematic review to report on the existing knowledge on this driver. This systematic review consists in the main source of evidence for the section. In addition, further references suggested by internal reviewers (ZOD and FOD) and external reviewer (FOD) were revised and included, when appropriate.
title: Protecting Borders or Individual Rights? A Comparative Due Process Rights Analysis of EU and Member State Responses to 'Weaponised' Migration
Creators: name: Peerboom, Felix
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2022
Subjects: subject: 'weaponisation' of migration
subject: Member States and EU reforms
subject: EU asylum law
subject: EU fundamental rights law
subject: Lithuania
subject: Greece

description: European Papers - A Journal on Law and Integration, 2022 7 (2), 583-600
description: European Forum Insight of 17 September 2022
description: I. Introduction. - II. The 'weaponisation' of migration in an EU context. - III. EU and Member State reforms and the impact on due process rights. - III.1. Lithuanian reforms. - III.2. Greek reforms. - III.3. EU reforms. - IV. Common trends and concluding thoughts.
description: In recent years the EU and its Member States have claimed to be increasingly targeted by “weaponised” migration. Due to the contemporary sensitivity of migration-related issues in the EU, neighbouring states are supposedly using the threat of increased migration to force the Union’s hand in other policy areas. Below, several recent examples of this supposedly happening will be dis-cussed, with an emphasis on: (i) the 2021 crisis along the Lithuania-Belarus external border; and (ii) the Turkish decision to briefly open its borders with Greece in February 2020. While the phenomenon of “weaponised” migration raises numerous legal questions, this Insight focusses only on the responses of self-proclaimed “targets” within a European context: the EU and its Member States. With the aim of understanding the impact of Lithuanian, Greek, and EU reforms on due process rights of the migrants supposedly being “weaponised”, the most prominent reforms will be critically scrutinised from the perspective of EU asylum and fundamental rights law. In this Insight, it will be argued that the EU and its Member States strongly favour border security over the due process rights of the migrants involved, reflecting a wider trend of a normalisation of illegal practices at both domestic and EU level.
Comprehensive mandatory policies are needed to fully protect all children from unhealthy food marketing
Creators: name: Stoltze, Fernanda Mediano
name: Popkin, Barry M.
name: Carpentier, Francesca R. Dillman
Publisher: name: Public Library of Science
Year: 2023

description: The World Health Organization (WHO) have released a new guideline, “Policies to protect children from the harmful impact of food marketing” [1] which recommends the development of comprehensive laws to reduce children’s exposure to unhealthy food marketing. This new guideline extends previous recommendations [2] to limit the adverse effects of unhealthy food marketing on the health of the world’s children. We consider here whether these new recommendations go far enough.
TNFα is required for cholestasis-induced liver fibrosis in the mouse
Creators: name: Rippe, Richard A.
name: Gäbele, Erwin
name: Uesugi, Takehiko
name: Froh, Matthias
name: Schölmerich, Jürgen
name: Hellerbrand, Claus
name: Brenner, David A.
name: Arteel, Gavin E.
name: Thurman, Ronald G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: TNFα, a mediator of hepatotoxicity in several animal models, is elevated in acute and chronic liver diseases. Therefore, we investigated whether hepatic injury and fibrosis due to bile duct ligation (BDL) would be reduced in TNFα knockout mice (TNFα−/−). Survival after BDL was 60% in wild-type mice (TNFα+/+) and 90% in TNFα−/− mice. Body weight loss and liver to body weight ratios were reduced in TNFα−/− mice compared to TNFα+/+ mice. Following BDL, serum alanine transaminases (ALT) levels were elevated in TNFα+/+ mice (268.6 ± 28.2 U/L) compared to TNFα−/− mice (105.9 U/L ± 24.4). TNFα −/− mice revealed lower hepatic collagen expression and less liver fibrosis in the histology. Further, α-smooth muscle actin, an indicator for activated myofibroblasts, and TGF-β mRNA, a profibrogenic cytokine, were markedly reduced in TNFα−/− mice compared to TNFα+/+ mice. Thus, our data indicate that TNFα induces hepatotoxicity and promotes fibrogenesis in the BDL model.
The abundance and colours of galaxies in high redshift clusters in the cold dark matter cosmology
Creators: name: Merson, Alexander I.
name: Baugh, Carlton M.
name: Gonzalez-Perez, Violeta
name: Abdalla, Filipe B.
name: Lagos, Claudia del P.
name: Mei, Simona
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: High-redshift galaxy clusters allow us to examine galaxy formation in extreme environments. Here we compile data for 15 $z>1$ galaxy clusters to test the predictions from a state-of-the-art semi-analytical model of galaxy formation. The model gives a good match to the slope and zero-point of the cluster red sequence. The model is able to match the cluster galaxy luminosity function at faint and bright magnitudes, but underestimates the number of galaxies around the break in the cluster luminosity function. We find that simply assuming a weaker dust attenuation improves the model predictions for the cluster galaxy luminosity function, but worsens the predictions for the red sequence at bright magnitudes. Examination of the properties of the bright cluster galaxies suggests that the default dust attenuation is large due to these galaxies having large reservoirs of cold gas as well as small radii. We find that matching the luminosity function and colours of high-redshift cluster galaxies, whilst remaining consistent with local observations, poses a challenge for galaxy formation models.
description: Corrected author list. 20 pages, 14 figures, 2 tables
Regulation of ryanodine receptors by sphingosylphosphorylcholine: Involvement of both calmodulin-dependent and -independent mechanisms
Creators: name: Kovacs, Erika
name: Liliom, Karoly
name: Xu, Le
name: Pasek, Daniel A.
name: Meissner, Gerhard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Sphingosylphosphorylcholine (SPC), a lipid mediator with putative second messenger functions, has been reported to regulate ryanodine receptors (RyRs), Ca2+ channels of the sarco/endoplasmic reticulum. RyRs are also regulated by the ubiquitous Ca2+ sensor calmodulin (CaM), and we have previously shown that SPC disrupts the complex of CaM and the peptide corresponding to the CaM-binding domain of the skeletal muscle Ca2+ release channel (RyR1). Here we report that SPC also displaces Ca2+-bound CaM from the intact RyR1, which we hypothesized might lead to channel activation by relieving the negative feedback Ca2+CaM exerts on the channel. We could not demonstrate such channel activation as we have found that SPC has a direct, CaM-independent inhibitory effect on channel activity, confirmed by both single channel measurements and [3H]ryanodine binding assays. In the presence of Ca2+CaM, however, the addition of SPC did not reduce [3H]ryanodine binding, which we could explain by assuming that the direct inhibitory action of the sphingolipid was negated by the simultaneous displacement of inhibitory Ca2+CaM. Additional experiments revealed that RyRs are unlikely to be responsible for SPC-elicited Ca2+ release from brain microsomes, and that SPC does not exert detergent-like effects on sarcoplasmic reticulum vesicles. We conclude that regulation of RyRs by SPC involves both CaM-dependent and -independent mechanisms, thus, the sphingolipid might play a pysiological role in RyR regulation, but channel activation previously attributed to SPC is unlikely.
กระบวนการทางการทูต และความหลากหลายทางวัฒนธรรม
Creators: name: ชุติมา สุดจรรยา
Publisher: name: บัณฑิตศึกษา สถาบันบัณฑิตพัฒนศิลป์ กระทรวงวัฒนธรรม
Year: 2023
Subjects: การทูต
กระบวนการทางการทูต
ความหลากหลายทางวัฒนธรรม

description: วิพิธพัฒนศิลป์, 3, 2, 47-65
Editorial: Curbing global warming with multi-scale and multi-sectoral Water-Energy-Food nexus
Creators: name: Hong J.
name: Zhong H.
name: Peng X.
name: Chen H.
name: Song K.
Publisher: name: Frontiers Media SA
Year: 2023

description: Food, energy, and water play fundamental roles in human life and development. The rapid growth of global population requires increasing demand for agriculture product, renewable energy, and water resource supplies. Such demands echo with the United Nation’s Sustainable Development Goals (SDGs), especially zero hunger (Goal 2), clean water and sanitation (Goal 6), and affordable and clean energy (Goal 7) in the shared blueprint for people and planet’s future.
Editorial: Epigenetic insights into diagnostic and therapeutic applications
Creators: name: Pattenden S.G.
name: Jerónimo C.
name: Perry A.S.
name: Fratta E.
Publisher: name: Frontiers Media SA
Year: 2023

description: Studies of the heredity and variation in DNA sequence that directs normal development of all living organisms has fundamentally reshaped our understanding of human disease. However, a greater focus on an additional layer of information that does not depend on the underlying DNA sequence referred to as “epigenetics”, has emerged. Epigenetic processes have been recognized as critical for refining DNA-encoded instructions that direct cellular function, and there is increasing evidence that epigenetic dysregulation plays a central role in human disease. In contrast to irreversible genetic mutations, alterations to epigenetic pathways are dynamic, making them attractive therapeutic targets.
COMPARATIVE STUDY OF VARIOUS DISINFECTANTS EFFICIENCY IN POULTRY FARMS
Creators: name: Samiuddin Rahil
name: Anayetullah Janati
name: Weqar, Sayed Mohammad
name: Qiamudin Shinwari
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2023
Subjects: DISINFECTION
PREVENTION
MICRO-ORGANISMS
POULTRY FARM
DISEASE

description: Pathogenic Micro-organisms are contaminating poultry or animal farms through various ways such as air, water, labors, feeds, insects, birds etc. For this reason, need to have biological risk management protocols, which are important to prevent, control and removing the risks of diseases and spread of microbes. Disinfection protocols, when implemented appropriately, economically and according to productivity rate is better for the reducing pathogenic Micro-organisms and it is a significant step for several biological risk Management programs and preventions from various diseases. Anticipation and disinfection of disease is normally very easier, economically and medically effective than addressing outbreak circumstances of the diseases. Therefore, general awareness about systematically disinfection protocol for the control and prevention of infectious disease has become chief for poultry farms and control of the diseases which is need to become develop. Aim of this study is to evaluate the efficiency of some available disinfectants in poultry farms and examine of its advantages and benefits against the control of various diseases. Four broiler farms were selected for the experiment, which had treated with three types of disinfectants: Veterinary Disinfectant cleaner, glutaraldehyde , quaternary ammonium salt and last one is the control group. Finally the result had shown a farm in which we had used Veterinary Disinfectant cleaner spray economically was better than other three groups. Similarly glutaraldehyde treated farm are better in second stage and quaternary ammonium salt treated farm are less economically better than the control group. Thus using of disinfectant in farm reducing the pressure and load of micro-organism and prevent farm from various diseases.
PLATO Complementary Science
Creators: name: Aerts, Conny
name: Tkachenko, Andrew
Publisher: name: Zenodo
Year: 2024

description: ESA's PLATO space project stands for PLAnetary Transits and Oscillations of stars. The nominal mission has a 4-year duration, with an extension option of up to 8 years of operations. PLATO's launch is scheduled for December 2026 and after its cruise to L2 and the commissioning, its 26 telescopes will stare for a minimum of 2 years at its identified first southern field-of-view (aka LOPS2). The Core Science program of the mission concerns the detection and characterization of anunprecedented sample of exoplanets, with emphasis on planets in the habitable zone of Sun-like host stars.  Aside from its Core program, PLATO has an extensive Complementary Science program (PLATO-CS) for 8% of the total data rate. PLATO-CS has the aim to maximize the scientific return of the mission. This will be achieved via a Guest Observer (GO) program open to the worldwide community. In this invited talk, we present an overview and the current status of the PLATO-CS activities. Their aim is to optimally prepare the stellar, galactic, and extragalactic science communities to submit competitive GO proposals by investigating and showcasing the capabilities of the mission. We provide several examples of scientifictopics fitting in PLATO-CS's realm, backed by preparatory work based on existing photometric surveys and/or PLATO simulations.
Editorial: Mechanisms underlying the interactions between stress and pain
Creators: name: Florea R.
name: Géranton S.M.
name: Linnstaedt S.D.
Publisher: name: Frontiers Media SA
Year: 2023

description: Chronic pain results from a complex interplay between biological, psychological, and socioeconomic factors. To date, numerous risk factors have been associated with the increased susceptibility to chronic pain, from mental health state and lifestyle, to gender and the presence of medical comorbidities, such as insomnia and cardiovascular diseases. Despite the identification of these risk factors, managing chronic pain, let alone preventing it, remains a major clinical challenge. This is because the specific circuits and mediators underlying the diverse components of the multidimensional experience of pain are not specific to the processing of nociceptive information and are often engaged in response to other bodily threats, including stress exposure. This prompts the need for clinical and preclinical studies that examine the multifaceted aspects of chronic pain and how these may overlap with other long-term conditions.
The effect of spermine on the initiation of mitochondrial protein synthesis
Creators: name: Haque, Md. Emdadul
name: Spremulli, Linda L.
name: Christian, Brooke E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Polyamines are important in both prokaryotic and eukaryotic translational systems. Spermine is a quaternary aliphatic amine that is cationic under physiological conditions. In this paper, we demonstrate that spermine stimulates fMet-tRNA binding to mammalian mitochondrial 55S ribosomes. The stimulatory effect of spermine is independent of the identity of the mRNA. The degree of stimulation of spermine is the same at all concentrations of mitochondrial initiation factor 2 (IF2mt) and mitochondrial initiation factor 3 (IF3mt). This observation indicates that IF2mt and IF3mt, while essential for initiation, are not the primary components of the translation initiation system affected by spermine. IF3mt dissociates 55S ribosomes detectably in the absence of spermine, but this effect is strongly inhibited in the presence of spermine. This observation indicates that the positive effect of spermine on initiation is not due to an increase in the availability of the small subunits for initiation. Spermine also promotes fMet-tRNA binding to small subunits of the mitochondrial ribosome in the presence of IF2mt. The major effect of spermine in promoting initiation complex formation thus appears to be on the interaction of fMet-tRNA with the ribosome.
Editorial: Meiosis in plants: sexual reproduction, genetic variation and crop improvement
Creators: name: Chen, Changbin
name: Copenhaver, Gregory P.
name: Wang, Yingxiang
name: Wang, Chung-Ju Rachel
Publisher: name: Frontiers Media SA
Year: 2023

description: Meiosis is essential for sexual reproduction and required for the formation of sperm and egg; its central events are the associations between homologous chromosomes (homologs), including pairing, synapsis, recombination and segregation. During recombination, the exchange of DNA between homologs results in new allelic combinations between the parents and offspring and among individual progeny (Wang and Copenhaver, 2018). This genetic variation is the foundation for biodiversity and speciation. The phenotypic diversity that results from genetic variation is also used to develop new elite traits during commercial plant and animal breeding practices. Thus, understanding the molecular mechanisms drive and regulate plant meiosis can accelerate crop improvement, and provide a theoretical foundation for the development and maintenance of new agricultural varieties.
Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1
Creators: name: Kusuhara, Hiroyuki
name: Sato, Takashi
name: Koga, Tomoaki
name: Suzuki, Shingo
name: Cyr, Douglas M.
name: Sugiyama, Takashi
name: Kai, Hirofumi
name: Shuto, Tsuyoshi
name: Suico, Mary Ann
name: Sugiyama, Yuichi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Human breast cancer resistance protein (BCRP)/MXR/ABCG2 is a well-recognized ABC half-transporter that is highly expressed at the apical membrane of many normal tissues and cancer cells. BCRP facilitates disposition of endogenous and exogenous harmful xenobiotics to protect cells/tissues from xenobiotic-induced toxicity. Despite the enormous impact of BCRP in the physiological and pathophysiological regulation of the transport of a wide variety of substrates, little is known about the factors that regulate posttranslational expression of BCRP. Here, we identified Derlin-1, a member of a family of proteins that bears homology to yeast Der1p, as a posttranslational regulator of BCRP expression. Overexpression of Derlin-1 suppressed ER to Golgi transport of wild-type (WT) BCRP that is known to be efficiently trafficked to the plasma membrane. On the other hand, protein expression of N596Q variant of BCRP, N-linked glycosylation- deficient mutant that preferentially undergoes ubiquitin-mediated ER-associated degradation (ERAD), was strongly suppressed by the overexpression of Derlin-1, whereas knockdown of Derlin-1 stabilized N596Q protein, suggesting a negative regulatory role of Derlin-1 for N596Q protein expression. Notably, knockdown of Derlin-1 also stabilized the expression of tunicamycin-induced deglycosylated WT BCRP protein, implying the importance of glycosylation state for the recognition of BCRP by Derlin- 1. Thus, our data demonstrate that Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression and provide a novel posttranslational regulatory mechanism of BCRP by Derlin-1.
Editorial: Vagus nerve-mediated drive in supporting homeostasis: optimizing global health through monitoring and stimulating vagal function
Creators: name: Niezgoda A.
name: Rangon C.M.
name: Porges S.W.
name: Moyse E.
Publisher: name: Frontiers Media SA
Year: 2023

description: Epigenetics encompasses the changes in gene expression triggered by environmental cues that occur without altering the underlying DNA sequences. Although epigenetics involves a limited number of identified mechanisms so far (DNA methylation, histone modifications and noncoding RNAs), the field of Epigenetics is spreading rapidly over integrated physiopathology (Jeffries, 2020). The importance of epigenetics has been acknowledged in cancer (Sun et al., 2022), sepsis (Binnie et al., 2020), autoimmune/inflammatory diseases (Surace and Hedrich, 2019), addiction (Hamilton and Nestler, 2019), aging (Pal and Tyler, 2016; Pérez et al., 2022), neurodegenerative diseases (Berson et al., 2018; Zhang et al., 2022) and even in neurodevelopmental (Esposito et al., 2018; Wu et al., 2020) and psychiatric diseases (Abdolmaleky et al., 2023). Likewise, a broad and expanding set of therapies in clinics have been potentialized by tuning the vagal complex of brainstem, i.e., the key neural node of homeostasis, via non-invasive Vagus Nerve Stimulation (VNS) (Hilz, 2022). Moreover, Heart Rate Variability (HRV), a physiologically validated and easily accessible read-out of the vagal tone (Lewis et al., 2012), is acknowledged as a polyvalent prognostic tool (Gidron et al., 2018; Mol et al., 2021). This is not surprising, since Epigenome is considered as a “mediator for host-microbiome crosstalk” (Peery et al., 2021) and since vagus nerve represents the fastest pathway of the Microbiota-Gut-brain Axis (Fülling et al., 2019). However, except for regulating neuro-inflammation (Chen et al., 2022), the mechanisms through which VNS influences peripheral and central nervous system plasticity are not well described yet, limiting therapeutic optimization (Morrison et al., 2020; Keute and Gharabaghi, 2021). Therefore, as the vagal complex (i.e., peripheral and brainstem components) is definitely prone to bring about epigenetic modulations, notably through neuro-endocrine stimuli (Gil et al., 2013), we questioned the epigenetic role of vagus nerve, in order to promote noninvasive VNS, guided by HRV monitoring, as a universal therapy to stay healthy.
Inelastic Maxwell models for monodisperse gas-solid flows
Creators: name: Kubicki, Aleksander
name: Garzó, Vicente
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The Boltzmann equation for $d$-dimensional inelastic Maxwell models is considered to analyze transport properties for monodisperse gas-solid suspensions. The influence of the interstitial gas phase on the dynamics of solid particles is modeled via a viscous drag force. The Chapman-Enskog method is applied to solve the inelastic Boltzmann equation to first order in the deviations of the hydrodynamic fields from their values in the homogeneous cooling state. Explicit expressions for the Navier-Stokes transport coefficients are \emph{exactly} obtained in terms of both the coefficient of restitution and the friction coefficient characterizing the amplitude of the external force. The conditions under which a hydrodynamic regime independent of the initial conditions is reached are widely discussed. Finally, the results derived here are compared with those previously obtained for inelastic hard spheres in steady state conditions by using the so-called first Sonine approximation.
description: 21 pages, 7 figures. A conceptual error (which does not affect the main scientific outcomes of the publised paper but slightly alters some intermediate results) has been fixed in this new version
การเปรียบเทียบผลสัมฤทธิ์การพัฒนาทักษะการรำเชิดฉิ่ง - เชิดจีน ด้วยการจัดการเรียนรู้แบบห้องเรียนกลับด้าน ในรายวิชาทักษะนาฏศิลป์ 1 สำหรับผู้เรียนระดับปริญญาตรีปีที่ 1
Creators: name: วรินทร์พร ทับเกตุ
Publisher: name: บัณฑิตศึกษา สถาบันบัณฑิตพัฒนศิลป์ กระทรวงวัฒนธรรม
Year: 2023
Subjects: การพัฒนาทักษะการรำเชิดฉิ่ง – เชิดจีน, การจัดการเรียนรู้, ห้องเรียนกลับด้าน

description: วิพิธพัฒนศิลป์, 3, 2, 16-32
Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase
Creators: name: Graves, Lee M.
name: Jones, Shannon Z.
name: Yang, Jing
name: Zimmerman, Eric I.
name: Huang, Min
name: Leisewitz, Andrea V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Equilibrative Nucleoside Transporters (ENTs) are facilitative transporters broadly selective for pyrimidine and purine nucleosides and are essential for the modulation of nucleoside concentration and nucleoside analog availability. Resistance to nucleoside-derived drugs strongly correlates with a deficiency of ENT1 expression in several tumor cells. Thus, it is crucial to understand the mechanisms by which this transporter is modulated. Using a mouse myeloid leukemic cell line as a model, we investigated whether stress-activated kinases regulate ENT1 expression and function. JNK activation, but not p38 MAPK results in rapid loss of mENT1 function, mRNA expression and promoter activity. c-Jun but not the mutant c-Jun Ser63/73Ala, decreased mENT1 promoter activity. Moreover cJun bound to an AP-1 site identified at −1196 of the promoter, suggesting a specific role for this transcription factor in mENT1 regulation. We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance.
Environmental monitoring of antimicrobial resistant bacteria in North Carolina water and wastewater using the WHO Tricycle protocol in combination with membrane filtration and compartment bag test methods for detecting and quantifying ESBL E. coli
Creators: name: Appling, K. Clark
name: Sobsey, Mark D.
name: Fisher, Michael B.
name: Durso, Lisa M.
Publisher: name: Public Library of Science
Year: 2023

description: Antimicrobial resistance (AMR) threatens human and animal health; effective response requires monitoring AMR presence in humans, animals, and the environment. The World Health Organization Tricycle Protocol (WHO TP) standardizes and streamlines global AMR monitoring around a single indicator organism, extended-spectrum-β-lactamase-producing Escherichia coli (ESBL-Ec). The WHO TP culture-based method detects and quantifies ESBL-Ec by spread-plating or membrane filtration on either MacConkey or TBX agar (supplemented with cefotaxime). These methods require laboratories and trained personnel, limiting feasibility in low-resource and field settings. We adapted the WHO TP using a simplified method, the compartment bag test (CBT), to quantify most probable numbers (MPN) of ESBL-Ec in samples. CBT methods can be used correctly in the field by typical adults after a few hours’ training. We collected and analyzed municipal wastewater, surface water, and chicken waste samples from sites in Raleigh and Chapel Hill, NC over an 8-month period. Presumptive ESBL-Ec were quantified using MF on TBX agar supplemented with cefotaxime (MF+TBX), as well as using the CBT with chromogenic E. coli medium containing cefotaxime. Presumptive ESBL-Ec bacteria were isolated from completed tests for confirmation and characterization by Kirby Bauer disk diffusion tests (antibiotic sensitivity) and EnteroPluri biochemical tests (speciation). Both methods were easy to use, but MF+TBX required additional time and effort. The proportion of E. coli that were presumptively ESBL in surface water samples was significantly greater downstream vs upstream of wastewater treatment plant (WWTP) outfalls, suggesting that treated wastewater is a source of ESBL-Ec in some surface waters. The CBT and MF+TBX tests provided similar (but not identical) quantitative results, making the former method suitable as an alternative to the more complex MF+TBX procedure in some applications. Further AMR surveillance using MF+TBX and/or CBT methods may be useful to characterize and refine their performance for AMR monitoring in NC and elsewhere.
Role of glycosaminoglycans of biglycan in BMP-2 signaling
Creators: name: Miguez, P.A.
name: Terajima, M.
name: Nagaoka, H.
name: Yamauchi, M.
name: Mochida, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Recently we have reported that biglycan (BGN) promotes osteoblast differentiation and that this function is due in part to its ability to positively modulate bone morphogenetic protein (BMP) functions. In this study we investigated the role of glycosaminoglycans (GAGs) of BGN in this function using in vitro and in vivo models. C2C12 myogenic cells were treated or untreated with BMP-2 alone or in combination with glycanated, partially glycanated or de-glycanated BGN, and the effects on BMP signaling and function were assessed by Smad1/5/8 phosphorylation and alkaline phosphatase (ALP) activity. Furthermore, the effect of de-glycanation of BGN on BMP-2 induced osteogenesis was investigated employing a rat mandible defect model. The defects were filled with collagen scaffolds loaded with glycanated, partially glycanated or de-glycanated BGN alone or in combination with a sub-optimal dose of BMP-2 (subBMP). In in vitro experiments, BMP signaling and function were the greatest when BMP-2 was combined with de-glycanated BGN among the groups tested. In the rat mandible experiments, μCT analyses revealed that the newly formed bone was significantly increased only when subBMP was combined with de-glycanated BGN. The data indicate that the GAG component of BGN functions as a suppressor for the BGN-assisted BMP function.
Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids
Creators: name: Matson, Steven W.
name: Redinbo, Matthew R.
name: McNamara, Dan E.
name: Keith Ballentine III, W.
name: Nash, Rebekah P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Bacterial plasmids propagate through microbial populations via the directed process of conjugative plasmid transfer (CPT). Because conjugative plasmids often encode antibiotic resistance genes and virulence factors, several approaches to inhibit CPT have been described. Bisphosphonates and structurally related compounds (BSRCs) were previously reported to disrupt conjugative transfer of the F (fertility) plasmid in E. coli. We have further investigated the effect of these compounds on the transfer of two additional conjugative plasmids, pCU1 and R100, between E. coli. The impact of BSRCs on E. coli survival and plasmid transfer was found to be dependent on the plasmid type, the length of time the E. coli were exposed to the compounds, and the ratio of plasmid donor to plasmid recipient cells. Therefore, these data indicate that BSRCs produce a range of effects on the conjugative transfer of bacterial plasmids in E. coli. Since their impact appears to be plasmid type-dependent, BSRCs are unlikely to be applicable as broad inhibitors of antibiotic resistance propagation.
การวอร์มเสียงร้องด้วยวิธีการบูรณาการศาสตร์กายบริหารเพื่อเสริมกระบวนการคิเนสเตติก
Creators: name: ภคอิงค์ภักดิ์ ศุภการ
Publisher: name: บัณฑิตศึกษา สถาบันบัณฑิตพัฒนศิลป์ กระทรวงวัฒนธรรม
Year: 2023
Subjects: การวอร์มเสียง
การบูรณาการศาสตร์
คิเนสเตติก

description: วิพิธพัฒนศิลป์, 3, 2, 33-46
Turbulence in the solar wind: spectra from Voyager 2 data at 5 AU
Creators: name: Fraternale, F.
name: Gallana, L.
name: Iovieno, M.
name: Opher, M.
name: Richardson, J. D.
name: Tordella, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Fluctuations in the flow velocity and magnetic fields are ubiquitous in the Solar System. These fluctuations are turbulent, in the sense that they are disordered and span a broad range of scales in both space and time. The study of solar wind turbulence is motivated by a number of factors all keys to the understanding of the Solar Wind origin and thermodynamics. The solar wind spectral properties are far from uniformity and evolve with the increasing distance from the sun. Most of the available spectra of solar wind turbulence were computed at 1 astronomical unit, while accurate spectra on wide frequency ranges at larger distances are still few. In this paper we consider solar wind spectra derived from the data recorded by the Voyager 2 mission during 1979 at about 5 AU from the sun. Voyager 2 data are an incomplete time series with a voids/signal ratio that typically increases as the spacecraft moves away from the sun (45% missing data in 1979), making the analysis challenging. In order to estimate the uncertainty of the spectral slopes, different methods are tested on synthetic turbulence signals with the same gap distribution as V2 data. Spectra of all variables show a power law scaling with exponents between -2.1 and -1.1, depending on frequency subranges. Probability density functions (PDFs) and correlations indicate that the flow has a significant intermittency.
description: 14 pages, 7 figures. Discussion improved since the previous version
"Ram Phat Cha" (รำพัดชา), the Trace of Indian Dance in the Siamese Royal Elephant Sacred Ceremony
Creators: name: Akarin Pongpandecha
Publisher: name: บัณฑิตศึกษา สถาบันบัณฑิตพัฒนศิลป์ กระทรวงวัฒนธรรม
Year: 2023
Subjects: phat cha dance, thot chuak - dam chuak royal ceremony
Devakarma
Ekadanta

description: วิพิธพัฒนศิลป์, 3, 2, 66-80
The Impact of the Use of E-Learning to the Students' Attitude
Creators: name: Usigan, Alvin
name: Talusan, Gavin
name: Ramos, Erika Andrea
name: Barredo, James
name: Hill, Irish Dianne
name: Torres, Lanz Jayson
name: Hicban, Roxanne Janella
name: Romero, Patrick Dominic
Publisher: name: figshare
Year: 2022
Subjects: subject: 130306 Educational Technology and Computing
subject: FOS: Educational sciences
subject: 130106 Secondary Education

description: This study aims to know if e-learning has a positive impact to the students’ attitude with theapplication of Fishbein’s ABC model of attitude (Fishbein, 1963). This study is limited only to the bona fide grade 12 students of the Senior High School Department of Colegio de San Juan de Letran-Manila who are currently enrolled in the school year 2018-2019 along with this, the study only focuses on e-learning, but not as a certain tool. This study will be significant to its users and mostly students, they are the primary users of E-learning. Content- reators, for them to know what more to improve to their interface and features for better learning experience. Lastly, future researchers, this can be a good source and a basis for their studies