cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 4: Figure S1. of Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315
Creators: name: Sass, Andrea
name: Acker, Heleen Van
name: Förstner, Konrad
name: Nieuwerburgh, Filip Van
name: Deforce, Dieter
name: Vogel, Jörg
name: Coenye, Tom
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology

description: Transcription start sites confirmed by 5′RACE. dRNA-Seq data are represented as number of read starts per base and gRNA-Seq data as read coverage, both are visualised using the Integrated Genome Browser [51]. dRNA-Seq data are represented as read starts per base, gRNA-Seq data are represented as coverage. Blue arrows depict representative sequences derived from 5′RACE analysis. Panel A: pTSS of BCAL3153, confirmed by 2 out of 8 RACE sequences, 6 sequences were shorter than the putative 5′UTR. Panel B: pTSS of BCAL0672, confirmed by 5 out of 12 RACE sequences, 7 sequences were shorter than the putative 5′UTR. The isTSS internal to BCAL0672 was not confirmed by 5′RACE, transcripts originating from this locus are probably truncated. Panel C: pTSS of BCAL0301 confirmed by 2 out of 7 RACE sequences, 5 sequences were shorter than the putative 5′UTR. The isTSS located internal to BCAL0300 could not be confirmed, transcripts originating from this locus are probably truncated. Panel D: Internal pTSS of BCAL0063. 4 out of 5 RACE sequences confirmed the internal pTSS, one read was shorter. Panel E: isTSS within BCAL3201: 3 out of 9 RACE sequences confirmed the isTSS, 3 were shorter and 3 longer than the transcript originating at this TSS. Sequences were therefore derived from transcripts originating from this TSS as well as from TSS further upstream in the operon. Panel F: pTSS for BCAL3391, internal to BCAL3390: confirmed by 6 out of 6 RACE sequences. (PDF 114 kb)
Wie das TecLab den MINT-Nachwuchs fördert
Creators: name: Schiendorfer, Jana
Publisher: name: Berner Fachhochschule, Wirtschaft
Year: 2024

description: Fledermäuse, Solaranlagen, kreislauffähige Brücken oder kollaborative Roboter – das Themenfeld am TecLab ist breit. Hinter den Workshops und Kursen für Schülerinnen und Schüler steckt das Ziel, zukünftige Fachpersonen für MINT-Berufe zu motivieren. Das TecLab reflektiert Erfahrungen aus der Pilotphase.
Effects of Teaching English Using Phonics with Storybooks on Oral Reading Fluency of sixth Graders
Creators: name: Thoopthong Worratao
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยราชภัฏนครราชสีมา
Year: 2567
Subjects: หนังสือนิทาน
การอ่านคล่อง
โฟนิคส์

description: วารสารชุมชนวิจัยและพัฒนาสังคม, 18, 2, 346-362
MOESM2 of Maintenance-energy requirements and robustness of Saccharomyces cerevisiae at aerobic near-zero specific growth rates
Creators: name: Vos, Tim
name: Hakkaart, Xavier
name: Hulster, Erik
name: Maris, Antonius
name: Pronk, Jack
name: Daran-Lapujade, Pascale
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Number of genes identified in cluster 1 and 2 that overlap with genes identified in previous growth studies of which the expression correlated with specific growth rate. “Repressed” indicates a positive correlation, “induced” indicates a negative correlation, referring to the mode of regulation at low specific growth rates. Numbers outside the circle indicate the number of genes identified by the corresponding study, but not identified in the present study.
Additional file 2: Table S4. of Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study
Creators: name: Muller, David
name: Murphy, Neil
name: Johansson, Mattias
name: Ferrari, Pietro
name: Tsilidis, Konstantinos
name: Marie-Christine Boutron-Ruault
name: Francoise Clavel
name: Dartois, Laureen
name: Kuanrong Li
name: Kaaks, Rudolf
name: Weikert, Cornelia
name: Bergmann, Manuela
name: Boeing, Heiner
name: Tjønneland, Anne
name: Overvad, Kim
name: M. Redondo
name: Agudo, Antonio
name: Molina-Portillo, Elena
name: Altzibar, Jone
name: Lluís Cirera
name: Ardanaz, Eva
name: Kay-Tee Khaw
name: Wareham, Nicholas
name: Key, Timothy
name: Travis, Ruth
name: Bamia, Christina
name: Orfanos, Philippos
name: Trichopoulou, Antonia
name: Palli, Domenico
name: Pala, Valeria
name: Tumino, Rosario
name: Vineis, Paolo
name: Panico, Salvatore
name: H. Bueno-De-Mesquita
name: W. Verschuren
name: Struijk, Ellen
name: Peeters, Petra
name: Engström, Gunnar
name: Melander, Olle
name: Sund, Malin
name: Weiderpass, Elisabete
name: Skeie, Guri
name: Lund, Eiliv
name: Norat, Teresa
name: Gunter, Marc
name: Riboli, Elio
name: Brennan, Paul
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Population attributable fractions of deaths prior to age 75 years given the distribution of covariates in the EPIC cohort, using waist-to-hip ratio to assess for obesity. (PDF 76 kb)
Spinal Compressive Forces in Adolescent Idiopathic Scoliosis With and Without Carrying Loads: A Musculoskeletal Modeling Study
Creators: name: Schmid, Stefan
name: Burkhart, Katelyn A.
name: Allaire, Brett T.
name: Grindle, Daniel
name: Bassani, Tito
name: Galbusera, Fabio
name: Anderson, Dennis E.
Publisher: name: Frontiers Media
Year: 2020
Subjects: OpenSim
inverse dynamics
validation
spinal loading
AIS
muscle asymmetry
subject-specific modeling
backpack carrying

description: The pathomechanisms of curve progression in adolescent idiopathic scoliosis (AIS) remain poorly understood and biomechanical data are limited. A deeper insight into spinal loading could provide valuable information toward the improvement of current treatment strategies. This work therefore aimed at using subject-specific musculoskeletal full-body models of patients with AIS to predict segmental compressive forces around the curve apex and to investigate how these forces are affected by simulated load carrying. Models were created based on spatially calibrated biplanar radiographic images from 24 patients with mild to moderate AIS and validated by comparing predictions of paravertebral muscle activity with reported values from in vivo studies. Spinal compressive forces were predicted during unloaded upright standing as well as standing with external loads of 10, 15, and 20% of body weight (BW) applied to the scapulae to simulate carrying a backpack in the regular way on the back as well as in front of the body and over the shoulder on the concave and convex sides of the scoliotic curve. The predicted muscle activities around the curve apex were higher on the convex side for the erector spinae (ES) and multifidi (MF) muscles, which was comparable to the EMG-based in vivo measurements from the literature. In terms of spinal loading, the implementation of spinal deformity resulted in a 10% increase of compressive force at the curve apex during unloaded upright standing. Apical compressive forces further increased by 50–62% for a simulated 10% BW load and by 77–94% and 103–128% for 15% and 20% BW loads, respectively. Moreover, load-dependent compressive force increases were the lowest in the regular backpack and the highest in the frontpack and convex conditions, with concave side-carrying forces in between. The predictions indicated increased segmental compressive forces during unloaded upright standing, which could be ascribed to the scoliotic deformation. When carrying loads, compressive forces further increased depending on the carrying mode and the weight of the load. These results can be used as a basis for further studies investigating segmental loading in AIS patients during functional activities. Models can thereby be created using the same approach as proposed in this study.
MOESM13 of Maintenance-energy requirements and robustness of Saccharomyces cerevisiae at aerobic near-zero specific growth rates
Creators: name: Vos, Tim
name: Hakkaart, Xavier
name: Hulster, Erik
name: Maris, Antonius
name: Pronk, Jack
name: Daran-Lapujade, Pascale
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 13. Averaged normalized gene expression of housekeeping genes for S. cerevisiae strain CEN.PK113-7D [75]. Dotted bars indicate 20Â % variation around normalized expression.
Real Driving Emissions in Extended Driving Conditions
Creators: name: Engelmann, Danilo
name: Zimmerli, Yan
name: Czerwinski, Jan
Publisher: name: MDPI
Year: 2021

description: The real driving emission (RDE) testing for certification of vehicles is performed in conditions that are well defined in legislation. For emissions inventories and for research, the influences of some extended driving conditions on emissions are an interesting issue. In the present work, some examples of RDE results from two common passenger cars with gasoline and diesel propulsion are given. The varying driving conditions were “winter/summer”, “mild/aggressive”, and “higher altitude/slop”. The driving conditions: “winter”, “aggressive”, and “higher slope/altitude” gen-erally require more energy, cause higher fuel consumption, and therefore, higher CO2-emissions. The condition of “winter driving”, especially in the urban type of operation, may cause some longer phases with not enough warmed-up exhaust aftertreatment and consequently some in-creased gaseous emissions. The DPF eliminates the nanoparticles (PN) independently on the driving conditions. Nevertheless, the DPF regeneration has an influence on the CO2-normality of the trip. The CO2-normality primary tolerance range can also be exceeded with aggressive driving. The elaborated results confirm the usefulness of the existing legal limits for the driving conditions of RDE homologation tests.
Additional file 2: of RepeatAnalyzer: a tool for analysing and managing short-sequence repeat data
Creators: name: Catanese, Helen
name: Brayton, Kelly
name: Assefaw Gebremedhin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Figure S1. Geographic Visualization of repeats (Zoomed in to Venezuela from Figure 4). The figure shows the output of the query: Repeats: 10; 11; 12; 13; 14; 15; B; C; α; β; Γ, Strains: None, Location: Any, Scale: 1. Figure S2. Geographic Visualization of repeats (Zoomed out from Figure 5). The figure shows the output of the query: Repeats: α; β; Γ; EV1; EV3; EV7; EV6, Strains: EV1 β β β Γ; α β β β Γ; EV1 β β Γ; EV3 EV7 β β EV6, Location: Nayarit, Mexico, Scale: 1.5. (PDF 689 kb)
THE MOST EFFICIENT MARKETING STRATEGIES TO REPAIR BAD REPUTATION
Creators: name: Yusupov, R.M.
Publisher: name: Zenodo
Year: 2024

description: In the present digital age, reputation management has already become more critical than ever for business entities and entrepreneurs alike. Negative publicity or feedback is highly likely to spread rapidly through online channels while being responsible for significant damage to a brand's reputation. However, with the right marketing strategies, it is possible to repair a tarnished reputation and rebuild trust with stakeholders and consumers. This article looks into some of the most efficient marketing strategies for repairing a bad reputation and restoring credibility in the eyes of the public.
Additional file 8: Table S5. of Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study
Creators: name: Muller, David
name: Murphy, Neil
name: Johansson, Mattias
name: Ferrari, Pietro
name: Tsilidis, Konstantinos
name: Marie-Christine Boutron-Ruault
name: Francoise Clavel
name: Dartois, Laureen
name: Kuanrong Li
name: Kaaks, Rudolf
name: Weikert, Cornelia
name: Bergmann, Manuela
name: Boeing, Heiner
name: Tjønneland, Anne
name: Overvad, Kim
name: M. Redondo
name: Agudo, Antonio
name: Molina-Portillo, Elena
name: Altzibar, Jone
name: Lluís Cirera
name: Ardanaz, Eva
name: Kay-Tee Khaw
name: Wareham, Nicholas
name: Key, Timothy
name: Travis, Ruth
name: Bamia, Christina
name: Orfanos, Philippos
name: Trichopoulou, Antonia
name: Palli, Domenico
name: Pala, Valeria
name: Tumino, Rosario
name: Vineis, Paolo
name: Panico, Salvatore
name: H. Bueno-De-Mesquita
name: W. Verschuren
name: Struijk, Ellen
name: Peeters, Petra
name: Engström, Gunnar
name: Melander, Olle
name: Sund, Malin
name: Weiderpass, Elisabete
name: Skeie, Guri
name: Lund, Eiliv
name: Norat, Teresa
name: Gunter, Marc
name: Riboli, Elio
name: Brennan, Paul
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Hazard ratios and confidence intervals for death prior to age 70 years in the EPIC cohort. (PDF 76 kb)
Additional file 2: of Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study
Creators: name: Stagg, Helen
name: Abubakar, Ibrahim
name: Brown, James
name: Lalor, Maeve
name: H. Thomas
name: Tehreem Mohiyuddin
name: Pedrazzoli, Debora
name: Merle, Corinne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Flow chart of data. Flow chart documenting exclusion from the patient cohort. (DOCX 41 kb)
Real-time control of powder coating
Creators: name: Huwiler, Ursin
name: Rehm, Klaus
Year: 2018

description: Powder coating on MDF is still largely intuitive and experience-based. Processes are tuned until the result meets the requirements, which currently is assessed visually or destructively. The Swiss company Winterthur Instruments has developed the coatmaster, based on a thermal measuring method called Advanced Thermal Optics, which for the first time accurately measures layer thickness of uncured powder on MDF in a noncontact and non-destructive manner. Thanks to the measurement of the uncured powder early in the process, online quality assurance can be carried out. Faulty production items are detected before they enter the curing process and appropriate measures can be taken. It allows a real-time control of the coating process as well as 100% quality documentation. The quality requirements of the customer are guaranteed for each component. The current miniaturization of technology and the automation of measurement processes offer even further potential for process control. Overall, the use of this system leads to an increase in the production efficiency and provides significant savings of powder material.
Additional file 1: of Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex
Creators: name: Becker, Noémie
name: Margos, Gabriele
name: Blum, Helmut
name: Krebs, Stefan
name: Graf, Alexander
name: Lane, Robert
name: Castillo-Ramírez, Santiago
name: Sing, Andreas
name: Fingerle, Volker
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: S1. Strains included in this study, date of isolation, biological source, MLST sequence type (ST), geographic origin and previously determined species designation. S2. Phylogenetic inference including outgroup B. duttonii. S3. Estimates of divergence in generations for Borrelia genospecies. S4. Genes showing nucleotide diversity (π) (Nei 1987) or Tajima’s D (Tajima 1989) values exceeding two standard deviations in each species with respect to the 114 genes under study. S5. Additional material and methods: Phylogeny reconstruction and recombination estimation for three genes in 12 reference Borrelia species. S6. Four-Gamete analysis of loci used by Morlon et al. [18]. S7. Phylogenies reconstructed with BEAST v1.7.5 of a) three genes studied by Morlon et al. [18] combined, b) fla, c) groEL and d) rrs. (PDF 460 kb)
Pinnotheridae De Haan 1833
Creators: name: Tsang, Ling Ming
name: Naruse, Tohru
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Pinnotheridae

description: Family Pinnotheridae De Haan, 1833
Pinnotheridea De Haan, 1833: 34.
Diagnosis. Carapace circular (mainly Pinnotherinae) to ellipsoidal (mainly Pinnixinae and Pinnixulalinae), dorsally vaulted to flat, regions generally ill-defined, carapace cuticle usually poorly calcified in female pinnotherines. Buccal cavern semicircular, large. Mxp3 obliquely placed in buccal cavern; ischium and merus indistiguishably fused (mainly pinnotherines) or with or without superficial suture (mainly pinnixines and pinnixualines), ischiomerus produced mesiosubdistally, somewhat hatchet-shaped; palp 2- or 3-segmented, small, 3-segmented species with slender to narrowly spatulated dactylus inserted subdistally on lateral margin (in situ) of propodus; ambulatory legs mostly symmetrical but bilaterally asymmetrical in some pinnotherines. Male pleonal somites and telson free, telson not usually markedly wider than pleonal somite 6. G1 simple, slender to rather stout, straight to broadly curved. G2 small. Female pleonal somites and telson free, covering most of thoracic sternum in large female.
Remarks. This study formally transfers Tetrias and Parapinnixa + Sakina from Pinnotheridae to their own families, Tetriasidae fam. nov. and Parapinnixidae, respectively. The monophyletic Pinnotheridae sensu stricto is the largest family in Pinnotheroidea and is comprised of nearly 300 species in 3 subfamilies and 59 genera (Ng et al. 2008; Ng & Ho 2016; Palacios Theil et al. 2016; Ahyong 2018; Ng 2018; Ng et al. 2019; Palacios Theil & Felder 2020; Ng & Ahyong 2022). Pinnotheridae exhibits high morphological diversity, especially between subfamilies. For instance, crabs from Pinnixinae and Pinnixulalinae mostly live in the tubes or burrows of other marine benthos (e.g. mud shrimps and annelids). They have a much wider carapace (i.e. high aspect ratio carapace) compared to more circular carapace observed in the species from Pinnotherinae that predominantly live endosymbiotically with bivalve hosts, or occasionally with gastropod, ascidian and echinoderm hosts (Hultgren et al. 2022).
description: Published as part of Tsang, Ling Ming & Naruse, Tohru, 2023, Recognition of Parapinnixidae Števčić, 2005, and Tetriasidae fam. nov. in Pinnotheroidea De Haan, 1833 (Crustacea: Brachyura: Thoracotremata), pp. 540-558 in Zootaxa 5249 (5) on page 544, DOI: 10.11646/zootaxa.5249.5.2, http://zenodo.org/record/7701343
Additional file 6: of Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study
Creators: name: Stagg, Helen
name: Abubakar, Ibrahim
name: Brown, James
name: Lalor, Maeve
name: H. Thomas
name: Tehreem Mohiyuddin
name: Pedrazzoli, Debora
name: Merle, Corinne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Sensitivity analyses â   multivariable random effects logistic regression of the association between clinician caseload at different thresholds and treatment outcome, post-toolkit. Sensitivity analyses setting the clinician caseload threshold to one and a level designated by recursive partitioning. (DOCX 24 kb)
Analysis of finger joints from beech wood
Creators: name: Franke, Bettina
name: Schusser, A.
name: Müller, Andreas
Year: 2014
Subjects: Hardwood Finger joints Production Testing FEM-Analysis

description: The hardwood stock in European forest increases with primary beech as the main representing species. To use the mechanical potential of hardwood, it is necessary to adopt wood products known for soft wood like glulam or cross laminated timber to provide construction materials and to find new sales markets. Finger joints play a key role for the production line to respect the less available sizes of boards due to the growing and drying characteristics of hardwood. To guarantee high quality products, the production parameters like profiles of finger joints, applicable adhesives and pressing pressure and pressing time are analysed in detail using experimental test series and a numerical model.
title: Sonographische Differenzierung erhöhter Cholestaseparameter
Creators: name: Janus, Tanja
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Hintergrund Im klinischen Alltag zeigen Patientinnen und Patienten regelmäßig erhöhte Cho- lestasewerte, die zum Teil auf eine beginnende, aber auch auf eine bereits fortgeschrittene, chronische Veränderung der Leber hindeuten können. Ihre Ausgeprägtheit lässt nicht rück- schließen auf die Dauer, Schwere oder Genese der zugrunde liegenden Lebererkrankung. Früh- zeitige Erkennung, sowie die weitere Differenzierung sind für die Therapie und den Krank- heitsverlauf von immenser Wichtigkeit. Diagnostisch ist zur weiteren Differenzierung das Mit- tel der Wahl der Ultraschall mit seinen unterschiedlichen Möglichkeiten wie der Dopplersono- graphie oder die ARFI. Ziel Ziel dieser prospektiven Studie ist die Bewertung diagnostischer Leistungen durch den Ultraschall mit entsprechendem Einsatz der Dopplersonographie und der ARFI zur Differen- zierung der Ausprägung und Genese einer nicht obstruktiv bedingten Erhöhung der Cholesta- sewerte. Methoden In diese Studie eingeschlossen wurden 127 Patientinnen und Patienten mit cholesta- tischer Hepatitis, die über den Zeitraum von 10 Monaten von 06/2017 bis 04/2018 an zwei Zentren klinisch, echokardiographisch, sonographisch und teils endoskopisch untersucht wur- den. Ergebnisse Die im Rahmen dieser Studie erhobenen Ergebnisse belegen, dass durch den Ein- satz der Sonographie mit der Doppler-Untersuchung der Leber und der Pfortader eine Diffe- renzierung bzgl. einer intrahepatischen oder kardialen bzw. weit fortgeschrittenen Genese mög- lich ist. Es zeigt sich bzgl. einer kardialen Erkrankung eine Sensitivität von 0.84 und eine Spe- zifität von 0.97 im Falle der Darstellung eines vermehrten Reflux der Lebervenen. Eine fortge- schrittene Parenchymveränderung i.S. einer Zirrhose kann durch die Darstellung des Leberve- nenflussprofils bei monophasischem Fluss mit einer Sensitivität von 0.78 und einer Spezifität von 0.95 diagnostiziert werden. Fazit Zur ersten Einteilung der Ausprägung und Genese erhöhter Cholestasewerte ist die So- nographie mit ihren zusätzlichen Funktionen der Doppler-Sonographie und der ARFI die Di- agnostik der Wahl. Sie lässt die Differenzierung einer biliären, kardialen oder intrahepatischen Genese auch bei nur leicht ausgeprägter hepatischer Erkrankung zu.
title: Zeitliche Entwicklung und unterschiedliche Muster der zellulären Rekonstitution nach Therapie von Krebserkrankungen im Kindes- und Jugendalter
title: Temporal evolution and differential patterns of cellular reconstitution after therapy for childhood cancers
Creators: name: Hofmann, Gina
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Hintergrund und Ziele Die Immunrekonstitution nach Therapie einer Krebserkrankung im Kindes- und Jugendalter ist für das posttherapeutische Infektionsrisiko und den optimalen Zeitpunkt der Revakzinierung von Bedeutung. Zahlreiche Studien beschreiben die Immunrekonstitution nach allogener hämatopoetischer Stammzelltransplantation. Die Regeneration des Immunsystems bei an Krebs erkrankten Kindern und Jugendlichen, die keine Transplantation erhalten haben, ist vor allem für die akute lymphoblastische Leukämie untersucht, weniger für solide Tumore. Das Ziel der vorliegenden Studie ist es, krankheits- und therapiespezifische Unterschiede in der zellulären Immunrekonstitution nach Krebserkrankungen im Kindesalter zu untersuchen. Auf deren Basis soll eine Grundlage für zukünftige Empfehlungen hinsichtlich der Beendigung der Infektionsprophylaxe sowie der Wiederaufnahme von Schutzimpfungen nach Beendigung der antineoplastischen Therapie geschaffen werden. Methoden In dieser retrospektiven monozentrischen Studie wurde die Regeneration der Gesamtleukozyten-, Neutrophilen- und Lymphozytenzahl als orientierende Indikatoren der posttherapeutischen Immunrekonstitution in einer großen Kohorte von n=52 Patienten mit akuter lymphoblastischer Leukämie (ALL), n=58 Patienten mit Morbus Hodgkin (HD) und n=28 Patienten mit Ewing-Sarkom (ES) erfasst. Ergebnisse und Beobachtungen Patienten mit ALL wiesen den raschesten Anstieg der Blutwerte auf und erreichten zwischen 4 und 5 Monaten nach Ende der Erhaltungstherapie die altersentsprechenden unteren Normwerte. Die beiden Patientengruppen mit HD und ES zeigten eine protrahierte Erholung der Gesamtleukozytenzahl und eine deutliche posttherapeutische Lymphopenie, welche bei zusätzlich bestrahlten Patienten mit HD am Stärksten ausgeprägt war. Schlussfolgerungen und Diskussion Die in dieser Arbeit angestellten Untersuchungen zeigen abhängig von den Grunderkrankungen und den applizierten Therapiemodalitäten unterschiedliche Verläufe der zellulären Regeneration nach Therapie von Krebserkrankungen im Kindes- und Jugendalter. Damit könnten sie zur Diskussion krankheits- und therapiespezifischer Empfehlungen für die Dauer der Infektionsprophylaxe und den optimalen Zeitraum der Revakzinierung beitragen.
Alte Sau
Creators: name: Scheeder, Martin
Publisher: name: Suisseporcs / SUISAG
Year: 2021

description: Die jüngst entdeckte und bislang älteste bekannte durch Menschen geschaffene gegenständliche Darstellung zeigt: ein Schwein. Offenbar war es in den tropischen Regionen eine sehr begehrte Jagdbeute und ist es bis heute geblieben – wo der ursprüngliche Regenwald noch besteht.
Additional file 6: Table S1. of Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study
Creators: name: Muller, David
name: Murphy, Neil
name: Johansson, Mattias
name: Ferrari, Pietro
name: Tsilidis, Konstantinos
name: Marie-Christine Boutron-Ruault
name: Francoise Clavel
name: Dartois, Laureen
name: Kuanrong Li
name: Kaaks, Rudolf
name: Weikert, Cornelia
name: Bergmann, Manuela
name: Boeing, Heiner
name: Tjønneland, Anne
name: Overvad, Kim
name: M. Redondo
name: Agudo, Antonio
name: Molina-Portillo, Elena
name: Altzibar, Jone
name: Lluís Cirera
name: Ardanaz, Eva
name: Kay-Tee Khaw
name: Wareham, Nicholas
name: Key, Timothy
name: Travis, Ruth
name: Bamia, Christina
name: Orfanos, Philippos
name: Trichopoulou, Antonia
name: Palli, Domenico
name: Pala, Valeria
name: Tumino, Rosario
name: Vineis, Paolo
name: Panico, Salvatore
name: H. Bueno-De-Mesquita
name: W. Verschuren
name: Struijk, Ellen
name: Peeters, Petra
name: Engström, Gunnar
name: Melander, Olle
name: Sund, Malin
name: Weiderpass, Elisabete
name: Skeie, Guri
name: Lund, Eiliv
name: Norat, Teresa
name: Gunter, Marc
name: Riboli, Elio
name: Brennan, Paul
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Number of participants in the EPIC cohort: overall, for premature deaths (prior to age 70 years), by country of recruitment and sex. (PDF 32 kb)
title: Mediterrane Ernährung an der Universitätsklinik Erlangen Analyse mediterraner Scoring-Modelle und Bewertung der Krankenhausmahlzeiten anhand eines modifizierten Scoring-Modells
Creators: name: Herrlinger, Yannick
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Die mediterrane Diät (MD) gilt allgemein als gesundheitsfördernde Ernährungsweise. Um dies zu validieren, wurden die bei Erstellung dieser Arbeit vorliegenden wissenschaftlichen Publikationen zum Thema MD analysiert, um die medizinischen Vorteile einer entsprechenden Diät zu identifizieren. Darüber hinaus wurden die in der Literatur gängigen Scoring-Modelle zur Evaluation einer MD zusammengefasst und auf ihre Anwendbarkeit für die vorliegende Fragestellung geprüft. Ziel dieser Arbeit war es, ein Scoring-Modell zu finden, mit der eine Bewertung der aktuellen Menülinien für Patienten im Rahmen einer MD während eines Aufenthalts in der Klinik für Psychiatrie des Universitätsklinikums Erlangen (UKE) möglich ist. Nach der Bewertung der einzelnen Scoring-Modelle von MD wurde der „Medi-Lite-Score“ (Sofi et al., 2017) als am geeignetsten für die Auswertung für die Fragestellung dieser Arbeit befunden. Anschließend wurde der Score aufgrund der spezifischen Gegebenheiten der Krankenhauskost am UKE modifiziert. Außerdem wurden die Makronährstoffe sowie die Bestellungen der einzelnen Menülinien für das Jahr 2021 ausgewertet und verglichen. In der Auswertung zeigten sich signifikante Unterschiede zwischen den einzelnen Menülinien anhand eines mediterranen Scoring-Modells sowie verschiedene Verteilungen der Makronährstoffe. Es konnten außerdem Divergenzen bei den Bestellungen der Menülinien im Vergleich der einzelnen Stationen der psychiatrischen Klinik aufgezeigt werden.
Fischgesundheit - eine Herausforderung für alle
Tagungsband der XVII. Gemeinschaftstagung der Deutschen, Österreichischen und Schweizer Sektionen der European Association of Fish Pathologists EAFP
Creators: name: (:Unav)
Publisher: name: Universität Bern, Zentrum für Fisch- und Wildtiermedizin
Year: 2021

description: Die XVII Gemeinschaftstagung der Deutschen, Österreichischen und Schweizer Sektionen der European Association of Fish Pathologists (E-APF) wurde vom 2. bis zum 9. Oktober im Hotel Au Parc in Fribourg (Freiburg im Üechtland) durchgeführt. Die Tagung stand unter dem Motto «Fischgesundheit – eine Herausforderung für alle». Dieses Motto veran-schaulicht, dass das Erhalten einer guten Gesundheit bei Wassertieren von zentraler Bedeutung ist, wobei hier der Ausdruck «Fisch» sehr weit gefasst werden muss, sind doch in den Tagungsthemen nicht nur Fische, sondern auch Krebstiere enthalten. Immer wieder treten neue Krankheiten sowohl bei freilebenden als auch bei unter menschlicher Obhut gehaltenen Was-sertieren auf, was einerseits für die Wissenschaft andererseits aber auch für die Halter von solchen Tieren eine Herausforderung bedeutet. Ohne die Zusammenarbeit von Wissenschaft, Medizin, Haltung und Naturbehörden ist eine erfolgreiche Lösung solcher Probleme kaum möglich. Dabei geht es aber nicht nur um neue Probleme, sondern auch seit langem bekannte Krankheiten können immer wieder eine Herausforderung darstellen, sei es, weil erfolgreiche Therapien fehlen oder nicht mehr verfügbar sind, sei es, weil Probleme wieder neu auftreten. Dazu kommen immer wieder neue gesetzliche Vorgaben, die es zu berücksichtigen gilt, sowie neu definierte Ansprüche bezüglich Tierhaltung und Tierwohl. Mit dem breit gefächerten thematischen Angebot versuchte die Tagung, Einblicke in diese Heraus-forderungen zu geben. Dabei dienten nicht nur Vorträge und Poster der Wissensvermittlung. Ebenso wichtig waren die persönlichen Kontakte, die einen regen Austausch unter den Teilnehmenden ermöglichten.
Sclerotherapy and prolotherapy for chronic patellar tendinopathies - a promising therapy with limited available evidence, a systematic review
Creators: name: Morath, Oliver
name: Beck, Manuel
name: Taeymans, Jan
name: Hirschmüller, Anja
Year: 2020

description: Chronic Patellar tendinopathy (CPT) is a frequent overuse disorder in athletes and active people. Sclerotherapy (ST) and prolotherapy (PT) are, among a wide range of conservative treatment options, two promising therapies and have shown positive results in other tendinopathies. Since the treatments' efficacy and safety are still not defined, this review sought to answer questions on recommendations for use in clinical utility, safety, and how to perform the injection in the most effective way. An electronic database search was conducted following the PRISMA guidelines. Inclusion criteria were set up according to the PICOS-scheme. Included were athletes and non-athletes of all ages with diagnosed painful CPT. Studies including patients suffering from patellar tendinopathy which can be originated to any systemic condition affecting the musculoskeletal system (e.g. disorders associated with rheumatism) and animal studies were excluded. Methodological quality (modified Coleman Methodology Score) and risk of bias (Cochrane Risk of Bias Assessment Tool 2.0) were assessed by two independent reviewers, with disagreements resolved with a third reviewer. The search yielded a total of 416 entries. After screening titles, abstracts, and full texts, ten articles were found for qualitative analysis. The mean Coleman Score was 64.57. Three randomized-controlled trials showed positive results with an increase in VISA-P score or a decrease in VAS or NPPS, respectively. The non-randomized studies confirmed the positive results as well. Among all ten studies no serious adverse events were reported. Based on this limited set of studies, there seems to be some evidence that ST and PT may be effective treatment options to treat pain and to improve function in patients with CPT. To strengthen this recommendation, more research is needed with larger volume studies and randomized controlled studies with long term follow up. LEVEL OF EVIDENCE: IV.
title: Grundlegende Untersuchungen zur Entwicklung Bioorthogonaler Reaktionssysteme auf Basis von Olefinmetathesereaktionen
Creators: name: Benkert, Tobias
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: DDC Classification::5 Naturwissenschaften::54 Chemie::547 Organische Chemie

description: Carrying out artificial chemical reactions in living cells is one of the greatest challenges in modern chemistry. To date, there are only a few reactions that are able to fulfil the strict constraints of a bioorthogonal reaction. In this work, fundamental studies on a bioorthogonal reaction system based on olefin metathesis have been investigated. Several synthetic routes to different systems were investigated and carried out. Particular attention was paid to the preparation of piperidine-labelled systems for future targeted use in cell lysosomes. Three different approaches were studied in detail and led to the conclusion that the detailed investigation of suitable fluorescent dyes prior to their direct synthesis is a more promising strategy, as no surprising discrepancies arise between the existing and the required properties of the systems for use in cells.
Additional file 5: of Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study
Creators: name: Stagg, Helen
name: Abubakar, Ibrahim
name: Brown, James
name: Lalor, Maeve
name: H. Thomas
name: Tehreem Mohiyuddin
name: Pedrazzoli, Debora
name: Merle, Corinne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Sensitivity analysis â   stratified multivariable random effects logistic regression of the association between hospital caseload and treatment outcome, adjusted for clinician caseload. Sensitivity analysis of the impact of including clinician caseload in the hospital caseload model. (DOCX 20 kb)
Irrweg oder Offenbarung? Albrechtsbergers "reinster Satz" in Theorie und Praxis
Creators: name: Zirwes, Stephan
Publisher: name: GMTH
Year: 2020

description: Johann Georg Albrechtsberger verfasste 1804 mit der Abhandlung Kurze Regeln des reinsten Satzes einen Nachtrag zu seiner Gründlichen Anweisung zur Composition (1790). Auf nur wenigen Seiten stellt er Überlegungen zu einer völlig dissonanzfreien Satztechnik an. Als Besonderheit schließt Albrechtsberger dabei die Verwendung der wohlklingenden bzw. konsonanten Quarte aus, die im Dreiklang zwischen dem Quint- und Oktavton bzw. im Sextakkord zwischen dem Terz- und Sextton entsteht. 1807 setzte Albrechtsberger seine theoretischen Überlegungen mit der Missa sine dissonantiis auch kompositorisch um. Im vorliegenden Text wird zunächst Albrechtsbergers Idee einer dissonanzlosen Musik genauer untersucht, anschließend werden anhand analytischer Beobachtungen zur Messvertonung satztechnische Konsequenzen für das Komponieren ohne Dissonanzen aufgezeigt.
Künstlerrollen im Kontext. Das Repertoire der Begleitrollen für Welte-Mignon und Welte-Philharmonie
Creators: name: Köpp, Kai
Publisher: name: Hochschule der Künste HKB
Year: 2017

description: Begleitrollen weisen über die Repertoiregrenzen der solistischen Tastenliteratur hinaus und bieten damit besonders lohnende Perspektiven für die Interpretationsforschung. Selbstspielende Klaviere und Orgeln, die auch Begleitmusik für Gesang und Instrumente spielten, gab es schon seit den 1880er-Jahren. Neu an dem Begleitrollen-Programm der Firma Welte mit 184 Einträgen für Welte-Mignon und 23 Einträgen für Welte-Philharmonie war der künstlerische Anspruch dieser Begleitungen. Dieser zeigt sich auch daran, dass zeitgenössische Komponisten die Begleitung zu eigenen Werken aufnahmen, darunter Gustav Mahler mit zwei Liedern und Cyril Scott mit sechs Liedern. Eine wichtige Frage ist, ob bei der Aufnahme ein realer Sänger oder Instrumentalist begleitet wurde. Der Beitrag demonstriert, wie sich aus den Informationen der Begleitstimme konkrete Hinweise auf die Interpretation der nicht dokumentierten Solostimme ableiten lassen.
Lebensereignisse: Neue Ansätze für eine individualisierte und gesundheitsförderliche Personalarbeit. Projekt LEO: Lebensereignisorientierte Personalarbeit
Creators: name: Clerc, Michael
name: Artho, Simone
name: Clerc, Isabelle
Publisher: name: Gesundheitsförderung Schweiz
Year: 2015

description: Die vorliegende Expertise thematisiert die aktuellen Herausforderungen des sich verändernden Arbeitskräfteangebots aus Sicht des betrieblichen Personalmanagements. Vor allem im Bereich der hoch qualifizierten Arbeit besteht in gewissen Branchen der Wirtschaft und in gewissen Berufsfeldern ein Fachkräftemangel. Die Bindung hoch qualifizierter Mitarbeitender und eine Mobilisierung weiterer Arbeitskräftereserven (v. a. Frauen, ältere ArbeitnehmerInnen, bereits Pensionierte, zu gering ausgebildete junge ArbeitnehmerInnen usw.) kann nur gelingen, wenn Unternehmen individuell auf ihre Mitarbeitenden eingehen und es ihnen ermöglichen, die Erwerbsarbeit so lange wie möglich mit Lebensereignissen in privaten Lebens- und Arbeitsbereichen zu vereinbaren. Die kritischsten Lebensereignisse finden zumeist im Privatleben statt, sind oft mit grossem Stress verbunden und können schwerwiegende gesundheitliche Folgen für die betroffenen Mitarbeitenden mit sich bringen.
Pinnotheroidea De Haan 1833
Creators: name: Tsang, Ling Ming
name: Naruse, Tohru
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda

description: Key to the families in Pinnotheroidea De Haan, 1833
1. Pereopod 2 or pereopods 2 and 3 distinctly larger, more inflated and longer than pereopods 4 and 5. G1 long, slender, markedly bent mesially at proximal one-third to quarter....................................... Parapinnixidae Števčić, 2005
- Pereopod 2 shorter than, and not more inflated than other pereopods. G1 slender to rather stout, variously curved but not markedly bent at proximal one-third to quarter.................................................................. 2
2. Mxp3 palp articles (carpus, propodus, dactylus) all large, each article is about two-thirds length of merus; dactylus always present, extending to base of ischiomerus when palp folded...................................... Tetriasidae fam. nov.
- Mxp3 palp articles (carpus, propodus, dactylus) may be developed but not always all large; dactylus present or absent, if present, extending at most to distal quarter of ischiomerus when palp folded.................. Pinnotheridae De Haan, 1833
description: Published as part of Tsang, Ling Ming & Naruse, Tohru, 2023, Recognition of Parapinnixidae Števčić, 2005, and Tetriasidae fam. nov. in Pinnotheroidea De Haan, 1833 (Crustacea: Brachyura: Thoracotremata), pp. 540-558 in Zootaxa 5249 (5) on page 550, DOI: 10.11646/zootaxa.5249.5.2, http://zenodo.org/record/7701343
Additional file 4: of Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study
Creators: name: Stagg, Helen
name: Abubakar, Ibrahim
name: Brown, James
name: Lalor, Maeve
name: H. Thomas
name: Tehreem Mohiyuddin
name: Pedrazzoli, Debora
name: Merle, Corinne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy

description: Sensitivity analysis â   multivariable random effects logistic regression of the association between clinician or hospital caseload and treatment outcome, with different clustering structures. Sensitivity analysis of the impact of different clustering structures on the clinician and hospital caseload models. (DOCX 30 kb)
Differential and shared effects of psychological skills training and mindfulness training on performance-relevant psychological factors in sport: a randomized controlled trial
Creators: name: Röthlin, Philipp
name: Horvath, Stephan
name: Trösch, Severin
name: Grosse Holtforth, Martin
name: Birrer, Daniel
Publisher: name: BioMed Central
Year: 2020
Subjects: Sport psychology Intervention Randomized controlled trial Psychological skills training Mindfulness Competitive sport Athletic performance Bayesian analysis

description: Background: Mental training intends to support athletes in mastering challenges in sport. The aim of our study was to investigate the differential and shared effects of psychological skills training and mindfulness training on psychological variables relevant to athletic performance (e.g., handling emotions or attention control). We assumed that each approach has its own strengths (e.g., mindfulness has a differential effect on the acceptance of emotions), but for some goals (e.g., attention control), both training forms are expected to be equally successful (i.e., shared effects). Methods: A total of 95 athletes (Mage = 24.43, SDage = 5.15; 49% female) were randomly assigned into three groups: psychological skills training intervention (PST), mindfulness training intervention (MT), and wait-list control group (WL). Participants completed a questionnaire battery before and after the training (pretest and posttest). We assessed mindfulness, use of mental strategies, handling of emotions, attention in training and competition, as well as the dealing with failure. The two intervention programs each consisted of four 90-min group workshops conducted over a period of 4 weeks. Results: Both interventions passed the manipulation check, that is, PST led to more mental strategies being used (probabilities > 95%), and MT led to an increase in two of three aspects of mindfulness (probabilities > 98%) when compared to WL. Compared to WL, both interventions equally improved in the ability to not let emotions interfere with performance (probabilities > 99%) and in controlling attention in training and competition (probabilities > 89%). To a lesser extend, both interventions showed shared improvements in dealing with failure indicated by more action orientation (probabilities > 82%). We found a differential effect of MT on decreased experiential avoidance: MT decreased compared to WL and PST (probabilities > 92%), whereas PST did not differ from WL. Conclusion: We conclude that both forms of mental training lead to improvements in performance-relevant psychological factors, especially concerning the handling of emotions and attention control. The results of our study suggest that different paths may lead to the desired outcomes, and accordingly, both forms of mental training seem justified.
Additional file 3: of Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study
Creators: name: Stagg, Helen
name: Abubakar, Ibrahim
name: Brown, James
name: Lalor, Maeve
name: H. Thomas
name: Tehreem Mohiyuddin
name: Pedrazzoli, Debora
name: Merle, Corinne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Sensitivity analysis â   multivariable random effects logistic regression of the association between clinician caseload and treatment outcomes in a restricted dataset of 10 hospitals. Sensitivity analysis restricted to 4,884 cases from 10 hospitals where the named clinician field was further checked. (DOCX 16 kb)