cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
Creators: name: Fukui, Yoshinori
name: Hawkins, Phillip T.
name: Rossman, Kent L.
name: Gambardella, Laure
name: Stephens, Len R.
name: Welch, Heidi C.
name: Anderson, Karen E.
name: Lawson, Campbell D.
name: Damoulakis, George
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: ABSTRACT G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small GTPases. The guanine-nucleotide-exchange factor (GEF) P-Rex1 is engaged downstream of GPCRs and phosphoinositide 3-kinase (PI3K) in many cell types, and promotes tumorigenic signalling and metastasis in breast cancer and melanoma, respectively. Although P-Rex1-dependent functions have been attributed to its GEF activity towards Rac1, we show that P-Rex1 also acts as a GEF for the Rac-related GTPase RhoG, both in vitro and in GPCR-stimulated primary mouse neutrophils. Furthermore, loss of either P-Rex1 or RhoG caused equivalent reductions in GPCR-driven Rac activation and Rac-dependent NADPH oxidase activity, suggesting they both function upstream of Rac in this system. Loss of RhoG also impaired GPCR-driven recruitment of the Rac GEF DOCK2, and F-actin, to the leading edge of migrating neutrophils. Taken together, our results reveal a new signalling hierarchy in which P-Rex1, acting as a GEF for RhoG, regulates Rac-dependent functions indirectly through RhoG-dependent recruitment of DOCK2. These findings thus have broad implications for our understanding of GPCR signalling to Rho GTPases and the actin cytoskeleton.
How environmental impact is considered in economic evaluations of critical care: A scoping review
Creators: name: Nguyen, Christina
name: Higgins, Lisa
name: Carrandi, Alayna
name: McGain, Forbes
name: Schoeler, Isabella
name: Thompson, Kelly
name: Taylor, Colman
name: Hensher, Martin
name: McAlister, Scott
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medical Specialties
subject: Critical Care
subject: Medicine and Health Sciences
subject: Environmental impact
subject: Health economics
subject: Scoping review
subject: Critical care

description: Reducing the carbon footprint in critical care requires data and costs for key healthcare inputs specific to critical care and robust methods to include and analyze these data in economic evaluations. Yet, a comprehensive review of how environmental impact data are incorporated into health economic evaluations in critical care has yet to be conducted. The purpose of this scoping review is to synthesize available literature on whether and how environmental impact is considered in health economic evaluations of critical care.
Analysis of timelike Thomsen surfaces - with deformations and singularities
Creators: name: Akamine, Shintaro
name: Cho, Joseph
name: Ogata, Yuta
Publisher: name: arXiv
Year: 2018
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53A10, 53A15, 53B30, 57R45

description: Timelike Thomsen surfaces are timelike minimal surfaces that are also affine minimal. In this paper, we make use of both the Lorentz conformal coordinates and the null coordinates, and their respective representation theorems of timelike minimal surfaces, to obtain a complete global classification of these surfaces and to characterize them using a geometric invariant called lightlike curvatures. As a result, we reveal the relationship between timelike Thomsen surfaces, and timelike minimal surfaces with planar curvature lines. As an application, we give a deformation of null curves preserving the pseudo-arclength parametrization and the constancy of the lightlike curvatures.
PDF [Download] This Disaster Loves You by Richard Roper
Creators: name: Bell
Publisher: name: Zenodo
Year: 2024

description: This Disaster Loves You by Richard Roper

 

 

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This Disaster Loves You

Richard Roper

Page: 400

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ISBN: 9780593540701

Publisher: Penguin Publishing Group

 

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Love and Other Disasters (2006) Did you know · Trivia. Both Matthew Rhys and Elliot Cowan have played the role of Mr. · Goofs. Jacks says that she was born in England but moved to America when  Dear 16-year old mentalexotica - between desire and disaster Jun 23, 2011 — Disaster Relief in 2023—“We See Firsthand Jehovah's Love” Jan 26, 2024 — Breathless: When Should You Say I Love You? Jul 16, 2019 — Beautiful Disaster: A Novel (Beautiful Disaster Series) Beautiful Disaster: A Novel (Beautiful Disaster Series). Jamie McGuire. Current Most of All You: A Love Story (Where Love Meets Destiny). Upcoming Event. Feb  Prayers In Times of Natural Disaster Let Our Cries Come Unto You. Most merciful and compassionate God, Giver of Life and Love, hear our prayers and let our cries come unto you. We  Are You a Master at Work but a Disaster at Love? Dec 17, 2022 — Richard Roper Not long to go! THIS DISASTER LOVES YOU, out Feb 13th. US: https://t.co/b0KeZoUuaa UK: https://t.co/CQvzbI1HX9.
Figure S9 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
[download pdf] Diam's
Creators: name: Harmon
Publisher: name: Zenodo
Year: 2024

description: Diam's pan Mélanie Georgiades

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Caractéristiques

Diam's

Mélanie Georgiades

Nb. de pages: 321

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782757835661

Editeur: Points

Date de parution: 2013

 

 

 

Téléchargement gratuit de nouveaux livres Diam's

 

Overview

Pour la première fois depuis 2009, Mélanie Georgiades, alias Diam's, sort de son silence. Dans une autobiographie sincère et émouvante, elle se livre sur sa carrière et ses choix de vie. Sans tabous, l'étoile du rap français raconte son enfance, la gloire, les larmes derrière les paillettes, sa solitude, son engagement humanitaire en Afrique, sa découverte de l'Islam, et sa renaissance.
Additional file 1 of Understanding the socioeconomic costs of dystrophic epidermolysis bullosa in Europe: a costing and health-related quality of life study
Creators: name: Angelis, A.
name: Mellerio, J. E.
name: Kanavos, P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Generic questionnaire instrument used for data collection.
Weakly minimal groups with a new predicate
Creators: name: Conant, Gabriel
name: Laskowski, Michael C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: Fix a weakly minimal (i.e., superstable $U$-rank $1$) structure $\mathcal{M}$. Let $\mathcal{M}^*$ be an expansion by constants for an elementary substructure, and let $A$ be an arbitrary subset of the universe $M$. We show that all formulas in the expansion $(\mathcal{M}^*,A)$ are equivalent to bounded formulas, and so $(\mathcal{M},A)$ is stable (or NIP) if and only if the $\mathcal{M}$-induced structure $A_{\mathcal{M}}$ on $A$ is stable (or NIP). We then restrict to the case that $\mathcal{M}$ is a pure abelian group with a weakly minimal theory, and $A_{\mathcal{M}}$ is mutually algebraic (equivalently, weakly minimal with trivial forking). This setting encompasses most of the recent research on stable expansions of $(\mathbb{Z},+)$. Using various characterizations of mutual algebraicity, we give new examples of stable structures of the form $(\mathcal{M},A)$. Most notably, we show that if $(G,+)$ is a weakly minimal additive subgroup of the algebraic numbers, $A\subseteq G$ is enumerated by a homogeneous linear recurrence relation with algebraic coefficients, and no repeated root of the characteristic polynomial of $A$ is a root of unity, then $(G,+,B)$ is superstable for any $B\subseteq A$.
description: 23 pages, final version incorporating referee comments
LA TRAICION DE ROMA (TRILOGIA AFRICANUS 3) leer epub gratis
Creators: name: White
Publisher: name: Zenodo
Year: 2024

description: LA TRAICION DE ROMA (TRILOGIA AFRICANUS 3) de SANTIAGO POSTEGUILLO

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LA TRAICION DE ROMA (TRILOGIA AFRICANUS 3)

SANTIAGO POSTEGUILLO

Número de páginas: 872

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788466664011

Editorial: S.A. EDICIONES B

Año de edición: 2018

 

 

 

 

 

Libros de Epub para descarga móvil LA TRAICION DE ROMA (TRILOGIA AFRICANUS 3)

 

Overview

 

Última novela de laTrilogía de Roma, en la que descubriremos el épico final de dos de los personajes más legendarios de la historia: Escipión y Aníbal.

«He sido el hombre más poderoso del mundo, pero también el más traicionado.»

Así comienza Publio Cornelio Escisión sus memorias enLa traición de Roma, para continuar con el final de dos de los más épicos personajes de la historia, Escisión y Aníbal.

Los eternos enemigos se encuentran una vez más en la batalla de Magnesia, un episodio casi desconocido dela historia de occidente. Pero además de batallas, el autor nos cuenta lo que ha sido de los hijos de Escisión; de sus enemigos, Marco Porcio Catón y de su aliado Graco; de la esclava Netikerty; de la prostituta Areté; de su fiel aliado Ledio; de Antíoco III, el rey de Siria; del ya anciano dramaturgo Plauto, que se pasea por las calles de Roma, y también de la mujer de Escisión, Emilia Tercia, digna hasta el final en medio de la mayor de las hecatombes públicas y privadas.

Con la electrizante prosa que lo caracteriza, Posteguillo nos transporta de nuevo a la antigua Roma para ser testigos privilegiados del ocaso de una vida tan intensa como desbordante:el final de la epopeya de Publio Cornelio Escisión y de todo su mundo en el marco...
Alignment-to-orientation conversion in a magnetic field at nonlinear excitation of the $D_2$ line of rubidium: experiment and theory
Creators: name: Auzinsh, M.
name: Berzins, A.
name: Ferber, R.
name: Gahbauer, F.
name: Kalvans, L.
name: Mozers, A.
name: Spiss, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We studied alignment-to-orientation conversion caused by excited-state level crossings in a nonzero magnetic field of both atomic rubidium isotopes. Experimental measurements were performed on the transitions of the $D_2$ line of rubidium. These measured signals were described by a theoretical model that takes into account all neighboring hyperfine transitions, the mixing of magnetic sublevels in an external magnetic field, the coherence properties of the exciting laser radiation, and the Doppler effect. In the experiments laser induced fluorescence (LIF) components were observed at linearly polarized excitation and their difference was taken afterwards. By observing the two oppositely circularly polarized components we were able to see structures not visible in the difference graphs, which yields deeper insight into the processes responsible for these signals. We studied how these signals are dependent on laser power density and how they are affected when the exciting laser is tuned to different hyperfine transitions. The comparison between experiment and theory was carried out fulfilling the nonlinear absorption conditions.
description: 11 pages, 13 figures
(2800) Thomas Henry Craddock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Understanding the socioeconomic costs of dystrophic epidermolysis bullosa in Europe: a costing and health-related quality of life study
Creators: name: Angelis, A.
name: Mellerio, J. E.
name: Kanavos, P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Medical unit cost sources.
Descargar PDF TERRITORIO COMANCHE
Creators: name: Heiden
Publisher: name: Zenodo
Year: 2024

description: TERRITORIO COMANCHE de ARTURO PEREZ-REVERTE

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TERRITORIO COMANCHE

ARTURO PEREZ-REVERTE

Número de páginas: 144

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788484502630

Editorial: DEBOLSILLO

Año de edición: 2017

 

 

 

 

 

Descargas gratuitas de libros electrónicos en línea TERRITORIO COMANCHE in Spanish

 

Overview

Una visión desde primera fla de la guerra de los Balcanes.En Territorio comanche, abandonando por primera vez su faceta de narrador de fcciones, Pérez-Reverte nos enfrenta con la visión más real y descarnada, no exenta de ternura e ironía, sobre el trabajo de los corresponsales de guerra en la ex Yugoslavia. Un relato apasionado que se lee como una novela y obliga a preguntarse si existe una ética en el flo entre la vida y la muerte.
Quantifying Uncertainty in Projections of Regional Climate Change: A Bayesian Approach to the Analysis of Multimodel Ensembles
Creators: name: Tebaldi, Claudia
name: Smith, Richard L.
name: Nychka, Doug
name: Mearns, Linda O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: A Bayesian statistical model is proposed that combines information from a multimodel ensemble of atmosphere-ocean general circulation models (AOGCMs) and observations to determine probability distributions of future temperature change on a regional scale. The posterior distributions derived from the statistical assumptions incorporate the criteria of bias and convergence in the relative weights implicitly assigned to the ensemble members. This approach can be considered an extension and elaboration of the reliability ensemble averaging method. For illustration, the authors consider the output of mean surface temperature from nine AOGCMs, run under the A2 emission scenario from the Synthesis Report on Emission Scenarios (SRES), for boreal winter and summer, aggregated over 22 land regions and into two 30-yr averages representative of current and future climate conditions. The shapes of the final probability density functions of temperature change vary widely, from unimodal curves for regions where model results agree (or outlying projections are discounted) to multimodal curves where models that cannot be discounted on the basis of bias give diverging projections. Besides the basic statistical model, the authors consider including correlation between present and future temperature responses, and test alternative forms of probability distributions for the model error terms. It is suggested that a probabilistic approach, particularly in the form of a Bayesian model, is a useful platform from which to synthesize the information from an ensemble of simulations. The probability distributions of temperature change reveal features such as multimodality and long tails that could not otherwise be easily discerned. Furthermore, the Bayesian model can serve as an interdisciplinary tool through which climate modelers, climatologists, and statisticians can work more closely. For example, climate modelers, through their expert judgment, could contribute to the formulations of prior distributions in the statistical model.
14-velocity and 18-velocity multiple-relaxation-time lattice Boltzmann models for three-dimensional incompressible flows
Creators: name: Zhang, Wenhuan
name: Shi, Baochang
name: Wang, Yihang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: In this paper, 14-velocity and 18-velocity multiple-relaxation-time (MRT) lattice Boltzmann (LB) models are proposed for three-dimensional incompressible flows. These two models are constructed based on the incompressible LBGK model proposed by He et al. (Chin. Phys., 2004, 13: 40-46) and the MRT LB model proposed by d'Humières et al. (Philos. Trans. R. Soc., A, 2002, 360: 437-451), which have advantages in the computational efficiency and stability, respectively. Through the Chapman-Enskog analysis, the models can recover to three-dimensional incompressible Navier-Stokes equations in the low Mach number limit. To verify the present models, the steady Poiseuille flow, unsteady pulsatile flow and lid-driven cavity flow in three dimensions are simulated. The simulation results agree well with the analytical solutions or the existing numerical results. Moreover, it is found that the present models show higher accuracy than d'Humières et al. model and better stability than He et al. model.
description: 56pages,14 figures
Figure S11 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
НЕВРОЛОГИЧЕСКИЕ ОСЛОЖНЕНИЯ И ЛЕЧЕНИЯ
Creators: name: Исматова, Ирода
Publisher: name: Zenodo
Year: 2024

description: Аритмия определяется как нарушение сердечного ритма. Определенные аритмии имеют гораздо более высокий уровень неврологических осложнений , включая инсульт, когнитивные нарушения и деменцию . Целью данной статьи является рассмотрение как прямых, так и косвенных причин неврологических проблем, вызванных аритмиями. Прямые осложнения аритмии могут включать инсульт, транзиторную ишемическую атаку (ТИА) и различные когнитивные нарушения. По данным Банка данных об инсульте, который разделил потенциальные прямые причины кардиоэмболического инсульта на сильные и слабые источники, сильными источниками этого типа ишемического инсульта считались как фибрилляция предсердий, так и синдром слабости синусового узла . Косвенные причины неврологических осложнений включают сердечно-легочную реанимацию, лекарства, кардиологические процедуры и кардиохирургические процедуры, используемые для лечения аритмий.
(2801) Winnie Amelia [McGowan]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
PDF EPUB Download Good Material by Dolly Alderton Full Book
Creators: name: Caballero
Publisher: name: Zenodo
Year: 2024

description: Good Material by Dolly Alderton

 

 

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Good Material

Dolly Alderton

Page: 336

Format: pdf, ePub, mobi, fb2

ISBN: 9780593801307

Publisher: Knopf Doubleday Publishing Group

 

French books free download pdf Good Material

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Strictification tensor product of 2-categories
Creators: name: Nikolić, Branko
Publisher: name: arXiv
Year: 2018
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 16B50, 18D35, 18G30

description: Given 2-categories $\mathcal{C}$ and $\mathcal{D}$, let $\textrm{Lax}(\mathcal{C},\mathcal{D})$ denote the 2-category of lax functors, lax natural transformations and modifications, and $[\mathcal{C},\mathcal{D}]_\mathrm{lnt}$ its full sub-2-category of (strict) 2-functors. We give two isomorphic constructions of a 2-category $\mathcal{C}\boxtimes\mathcal{D}$ satisfying $\textrm{Lax}(\mathcal{C},\textrm{Lax}(\mathcal{D},\mathcal{E})) \cong [\mathcal{C}\boxtimes \mathcal{D},\mathcal{E}]_\mathrm{lnt}$, hence generalising the case of the free distributive law $1\boxtimes 1$. We also discuss dual constructions.
ТУРИЗМ КАК СРЕДСТВО АДАПТАЦИИ ИНВАЛИДОВ К СОЦИАЛЬНОЙ СРЕДЕ
Creators: name: ДАЛЛАРИ АНТОНИНА АНТОНИ
Publisher: name: Концепт
Year: 2020
Subjects: СОЦИАЛЬНАЯ АДАПТАЦИЯ
ИНВАЛИДЫ
СОЦИАЛЬНАЯ ИНТЕГРАЦИЯ
АДАПТИВНЫЙ ТУРИЗМ
SOCIAL ADAPTATION
PEOPLE WITH DISABILITIES
SOCIAL INTEGRATION
ADAPTIVE TOURISM

description: В статье подчеркивается актуальность исследования туризма как средства адаптации инвалидов к социальной среде. Цель статьи изучение теоретических аспектов проблемы туризма как средства адаптации инвалидов к социальной среде, где адаптивный туризм выступает в качестве средства социальной интеграции инвалидов для актуализации их личностного развития. В ходе теоретического исследования было выявлено, что адаптивный туризм обладает огромным мобилизующим и оздоровительным потенциалом, так как расширяет жизненное пространство инвалидов с отклонениями в развитии опорно-двигательного аппарата и способствует их сближению со здоровыми людьми, что обусловливает их психологическую реабилитацию и социальную интеграцию в общество, активизируя их личностное развитие.The article emphasizes the relevance of tourism study as a means of adapting people with disabilities to the social environment. The purpose of the article is to study the theoretical aspects of tourism as a means of adapting people with disabilities to the social environment, where adaptive tourism acts as a means of social integration of people with disabilities to actualize their personal development. In the course of a theoretical study, it was found that adaptive tourism has a huge mobilizing and improving potential, as it extends the living environment of people with disabilities who suffer from musculoskeletal system impairments, and promotes their communication with healthy people, which determines their psychological rehabilitation and social integration in society, activating their personal development.
Table. S3 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Genomes used for standard phylogenetic analyses
Online Read Ebook The Night of the Storm: A Novel by Nishita Parekh
Creators: name: Warren
Publisher: name: Zenodo
Year: 2024

description: The Night of the Storm: A Novel by Nishita Parekh

 

 

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The Night of the Storm: A Novel

Nishita Parekh

Page: 336

Format: pdf, ePub, mobi, fb2

ISBN: 9780593473375

Publisher: Penguin Publishing Group

 

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Overview

From debut author Nishita Parekh, a fresh take on the classic locked-room thriller, about a multigenerational Indian American family marooned in a house with a murderer during Hurricane Harvey Hurricane Harvey is about to hit Houston. Meanwhile, single mom Jia Shah is already having a rough week: her twelve-year-old son, Ishaan, has just been suspended from school for getting in a fight. Still reeling from the fallout of her divorce—their move to Houston, her family’s disapproval, the struggle to make ends meet on her own—now Jia is worried about Ishaan’s future, too. Will her solo parenting be enough? Doesn’t a boy need a father? And now their apartment complex is under a mandatory evacuation order. Jia’s sister, Seema, has invited them to hunker down in her fancy house in Sugar Land, and despite Jia’s misgivings—Seema’s husband, Vipul, has been just a little too friendly with her lately—Jia concedes it’s probably the best place to keep Ishaan safe during the hurricane. With Jia’s philandering ex scrutinizing her every move, all too eager to snatch back custody of Ishaan, she can’t afford to make a mistake. When Vipul’s brother and his wife show up on Seema’s doorstep, too, it’s a recipe for disaster. Grandma, the family matriarch, has never been shy about playing favorites among her sons and their wives. As the storm escalates, tensions rise quickly, and soon someone’s dead. Was it a horrible accident or is there a murderer in their midst? With no help available until the floodwaters recede in the morning, Jia must protect her son and identify the culprit before she goes down for a crime she didn’t commit—or becomes the next victim. . . .
The Deligne-Mumford and the Incidence Variety Compactifications of the Strata of $Ω\mathcal{M}_{g}$
Creators: name: Gendron, Quentin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 14H10 (Primary) 14H45, 32J25 (Secondary)

description: The main goal of this work is to construct and study a reasonable compactification of the strata of the moduli space of Abelian differentials. This allows us to compute the Kodaira dimension of some strata of the moduli space of Abelian differentials. The main ingredients to study the compactifications of the strata are a version of the plumbing cylinder construction for differential forms and an extension of the parity of the connected components of the strata to the differentials on curves of compact type. We study in detail the compactifications of the hyperelliptic minimal strata and of the odd minimal stratum in genus three.
description: 58 pages, 5 figures
(2802) Benjamin Greenough
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Climate Variability, Fish, and Fisheries
Creators: name: van der Lingen, C. D.
name: Fromentin, J. M.
name: Ottersen, G.
name: Beaugrand, G.
name: Barange, M.
name: Perry, R. I.
name: Baumgartner, T.
name: Werner, F.
name: Drinkwater, K.
name: Lehodey, P.
name: Hare, S. R.
name: Alheit, J.
name: Roy, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Fish population variability and fisheries activities are closely linked to weather and climate dynamics. While weather at sea directly affects fishing, environmental variability determines the distribution, migra-tion, and abundance of fish. Fishery science grew up during the last century by integrating knowledge from oceanography, fish biology, marine ecology, and fish population dynamics, largely focused on the great Northern Hemisphere fisheries. During this period, understanding and explaining interannual fish recruit-ment variability became a major focus for fisheries oceanographers. Yet, the close link between climate and fisheries is best illustrated by the effect of "unexpected" events—that is, nonseasonal, and sometimes catastrophic—on fish exploitation, such as those associated with the El Niño–Southern Oscillation (ENSO). The observation that fish populations fluctuate at decadal time scales and show patterns of synchrony while being geographically separated drew attention to oceanographic processes driven by low-frequency signals, as reflected by indices tracking large-scale climate patterns such as the Pacific decadal oscillation (PDO) and the North Atlantic Oscillation (NAO). This low-frequency variability was first observed in catch fluctuations of small pelagic fish (anchovies and sardines), but similar effects soon emerged for larger fish such as salmon, various groundfish species, and some tuna species. Today, the availability of long time series of observations combined with major scientific advances in sampling and modeling the oceans' ecosystems allows fisheries science to investigate processes generating variability in abundance, distribution, and dy-namics of fish species at daily, decadal, and even centennial scales. These studies are central to the research program of Global Ocean Ecosystems Dynamics (GLOBEC). This review presents examples of relation-ships between climate variability and fisheries at these different time scales for species covering various marine ecosystems ranging from equatorial to subarctic regions. Some of the known mechanisms linking climate variability and exploited fish populations are described, as well as some leading hypotheses, and their implications for their management and for the modeling of their dynamics. It is concluded with recommendations for collaborative work between climatologists, oceanographers, and fisheries scientists to resolve some of the outstanding problems in the development of sustainable fisheries.
Figure S10 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
Additional file 3 of Understanding the socioeconomic costs of dystrophic epidermolysis bullosa in Europe: a costing and health-related quality of life study
Creators: name: Angelis, A.
name: Mellerio, J. E.
name: Kanavos, P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Table S1: Average annual costs per patient (SD), localised patients (n = 21, 2020 €) and Table S2: Average annual costs per patient (SD), generalised patients (n = 70, 2020 €).
(2798) Thomas West Mann
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Climatology of Cold-Season Nonconvective Wind Events in the Great Lakes Region
Creators: name: Durkee, Joshua D.
name: Knox, John A.
name: Fuhrmann, Christopher M.
name: Stewart, Alan E.
name: Lacke, Matthew C.
name: Dillingham, Sarah M.
name: Frye, John D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A 44-yr climatology of nonconvective wind events (NCWEs) for the Great Lakes region has been created using hourly wind data for 38 first-order weather stations during the months of November through April. The data were analyzed in terms of the two National Weather Service (NWS) criteria for a high-wind watch or warning: sustained winds of at least 18 m s-1for at least 1 h or a wind gust of at least 26 m s-1for any duration. The results indicate a pronounced southwest quadrant directional preference for nonconvective high winds in this region. Between 70% and 76% of all occurrences that satisfied the NWS criteria for NCWEs were associated with wind directions from 180° through 270°. Within the southwest quadrant, the west-southwest direction is preferred, with 14%-35% of all NCWEs coming from this particular compass heading. This directional preference is borne out in five out of six stations with high occurrences of cold-season NCWEs (Buffalo, New York; Dayton, Ohio; Lansing, Michigan; Moline, Illinois; Springfield, Illinois). Given the geographic spread of these stations, a nontopographic cause for the directional preference of cold-season NCWEs is indicated. The connection between NCWEs and low pressure systems found in this climatology and in case studies suggests that midlatitude cyclone dynamics may be a possible cause of the directional preference.
Deep neural networks algorithms for stochastic control problems on finite horizon: numerical applications
Creators: name: Bachouch, Achref
name: Huré, Côme
name: Langrené, Nicolas
name: Pham, Huyen
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: Computational Finance (q-fin.CP)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: This paper presents several numerical applications of deep learning-based algorithms that have been introduced in [HPBL18]. Numerical and comparative tests using TensorFlow illustrate the performance of our different algorithms, namely control learning by performance iteration (algorithms NNcontPI and ClassifPI), control learning by hybrid iteration (algorithms Hybrid-Now and Hybrid-LaterQ), on the 100-dimensional nonlinear PDEs examples from [EHJ17] and on quadratic backward stochastic differential equations as in [CR16]. We also performed tests on low-dimension control problems such as an option hedging problem in finance, as well as energy storage problems arising in the valuation of gas storage and in microgrid management. Numerical results and comparisons to quantization-type algorithms Qknn, as an efficient algorithm to numerically solve low-dimensional control problems, are also provided; and some corresponding codes are available on https://github.com/comeh/.
description: 39 pages, 14 figures. Methodology and Computing in Applied Probability, Springer Verlag, In press
Read [pdf]> Credence by Penelope Douglas
Creators: name: Garrison
Publisher: name: Zenodo
Year: 2024

description: Credence by Penelope Douglas

 

 

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Credence

Penelope Douglas

Page: 486

Format: pdf, ePub, mobi, fb2

ISBN: 9781660089055

Publisher: Independently published

 

Download free books online torrent Credence 9781660089055 (English literature)

How to pronounce CREDENCE in English Stream CREDENCE music CREDENCE (noun) definition and synonyms What Is Credence Resource Management? Culture & Philanthropy Credence Dynamo Solutions Credence (statistics) Credence High School Credence Definition & Meaning Credence
MPEC 2023-Q149 : 2023 QZ6
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 QZ6

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Gene Expression Profiling Reveals Reproducible Human Lung Adenocarcinoma Subtypes in Multiple Independent Patient Cohorts
Creators: name: Bhattacharjee, Arindam
name: Perou, Charles
name: Socinski, Mark A.
name: Naoki, Katsuhiko
name: Monti, Stefano
name: Meyerson, Matthew
name: Parmigiani, Giovanni
name: Gilks, C. Blake
name: Hayes, D. Neil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: PURPOSE: Published reports suggest that DNA microarrays identify clinically meaningful subtypes of lung adenocarcinomas not recognizable by other routine tests. This report is an investigation of the reproducibility of the reported tumor subtypes.

METHODS: Three independent cohorts of patients with lung cancer were evaluated using a variety of DNA microarray assays. Using the integrative correlations method, a subset of genes was selected, the reliability of which was acceptable across the different DNA microarray platforms. Tumor subtypes were selected using consensus clustering and genes distinguishing subtypes were identified using the weighted difference statistic. Gene lists were compared across cohorts using centroids and gene set enrichment analysis.

RESULTS: Cohorts of 31, 72, and 128 adenocarcinomas were generated for a total of 231 microarrays, each with 2,553 reliable genes. Three adenocarcinoma subtypes were identified in each cohort. These were named bronchioid, squamoid, and magnoid according to their respective correlations with gene expression patterns from histologically defined bronchioalveolar carcinoma, squamous cell carcinoma, and large-cell carcinoma. Tumor subtypes were distinguishable by many hundreds of genes, and lists generated in one cohort were predictive of tumor subtypes in the two other cohorts. Tumor subtypes correlated with clinically relevant covariates, including stage-specific survival and metastatic pattern. Most notably, bronchioid tumors were correlated with improved survival in early-stage disease, whereas squamoid tumors were associated with better survival in advanced disease.

CONCLUSION: DNA microarray analysis of lung adenocarcinomas identified reproducible tumor subtypes which differ significantly in clinically important behaviors such as stage-specific survival.