cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The Study of Oxygen Transport Through Polycrystalline, Single Crystal and Alloyed Silver
Creators: name: Wu, Dongchuan
Publisher: name: Old Dominion University Libraries
Year: 1990

description: The permeation of oxygen through large grain polycrystalline silver, through the (110), (111) and (100) single crystals of silver and through Ag0.05Zr alloy have been studied over the temperature range of 400 - 800 °C. In addition, studies were also conducted using glow discharge dissociation of the supply side ( upstream ) molecular oxygen in order to examine whether normal dissociative adsorption is a limiting step in the overall transport process.

The permeability of oxygen through polycrystalline silver was found to be quite linear and quite repeatable. The diffusivity measurements were found to exhibit two distinct linear regions, one above and one below a critical temperature of 630 °C. The high-temperature data have an activation energy (11.1 kcal/mole ) similar to that reported by others, but the low-temperature data have a comparatively larger activation energy ( 15.3 kcal/mole ) which is probably due to the higher efficiency of traps.

The permeability of oxygen through the (110), (111) and (100) single ·crystals of silver· all fell along a linear Arrhenius plot with the activation energy and the preexponential very similar to that found for the polycrystalline silver. This indicates that the transport limitation is approximately the same, even though there is some substantial difference in the microstructure. The magnitude of the diffusivity was found to be different for the three different crystal orientations which is inconsistent with the relation of K = DS since the solubility must be the same. The variation in the diffusivity can be explained by the relative displacement along a given crystallographic direction for a given number of jumps. The diffusivity ratios were in reasonable agreement with the ratio of the displacements squared.

The permeability for Ag0.05Zr alloy was found to be a fact of 1 .86 higher than polycrystalline silver. The 0.05 percent Zr gives a much higher grain boundary and defect density to provide more reservoirs for oxygen which will increase the solubility and give the higher permeability. The diffusivity data have a higher activation energy but are very close in magnitude to the polycrystalline silver.

The effect of the surface limitation on the transport was further examined by using a glow discharge on the upstream side to enhance the formation of oxygen atoms. It was found that the flux of oxygen substantially increased from the steady state dissociative adsorption level by a factor of 6. This indicates that there is a definite surface limitation for normal dissociative adsorption. The increased signal during the glow discharge suggests that the adsorption and dissolution rate for oxygen atoms is substantially greater than for the previously conducted permeation experiments where 02 molecules are dissociatively adsorbed.
-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription
Creators: name: Wilson, E. M.
name: Song, L.-N.
name: Herrell, R.
name: Byers, S.
name: Shah, S.
name: Gelmann, E. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: β-Catenin is a multifunctional molecule that is activated by signaling through WNT receptors. β-Catenin can also enhance the transcriptional activity of some steroid hormone receptors such as the androgen receptor and retinoic acid receptor α. Androgens can affect nuclear translocation of β-catenin and influence its subcellular distribution. Using mammalian two-hybrid binding assays, analysis of reporter gene transcription, and coimmunoprecipitation, we now show that β-catenin binds to the androgen receptor ligand-binding domain (LBD) and modulates the transcriptional effects of TIF2 and the androgen receptor N-terminal domain (NTD). In functional assays, β-catenin bound to androgen receptor only in the presence of ligand agonists, not antagonists. β-Catenin binding to the androgen receptor LBD was independent of and cooperative with the androgen receptor NTD and the p160 coactivator TIF2, both of which bind to the activation function 2 (AF-2) region of the androgen receptor. Different mutations of androgen receptor helix 3 amino acids disrupted binding of androgen receptor NTD and β-catenin. β-Catenin, androgen receptor NTD, and TIF2 binding to the androgen receptor LBD were affected similarly by a subset of helix 12 mutations, but disruption of two sites on helix 12 affected only binding of β-catenin and not of TIF2 or the androgen receptor NTD. Mutational disruption of each of five LXXLL peptide motifs in the β-catenin armadillo repeats did not disrupt either binding to androgen receptor or transcriptional coactivation. ICAT, an inhibitor of T-cell factor 4 (TCF-4), and E-cadherin binding to β-catenin also blocked binding of the androgen receptor LBD. We also demonstrated cross talk between the WNT and androgen receptor signaling pathways because excess androgen receptor could interfere with WNT signaling and excess TCF-4 inhibited the interaction of β-catenin and androgen receptor. Taken together, the data show that β-catenin can bind to the androgen receptor LBD and modulate the effects of the androgen receptor NTD and TIF2 on transcription.
Primacy & Ranking of UEFA Soccer Teams from Biasing Organizing Rules
Creators: name: Ausloos, Marcel
name: Gadomski, Adam
name: Vitanov, Nikolay K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: A question is raised on whether some implied regularity or structure, as found in soccer team ranking by the Union of European Football Associations (UEFA), is due to implicit game result value or score competition conditions. The analysis is based on considerations about complex systems, i.e. searching whether power or other simple law fits are appropriate to describe some internal dynamics. It is observed that the ranking is specifically organized: a major class made of a few teams emerges after each game season. Other classes which apparently have regular sizes subsequently occur. Thus, the notion of Sheppard primacy index is envisaged to describe the findings. Additional primacy indices are discussed for enhancing the features. These measures can be used to sort out peer classes in more general terms. A very simplified toy model containing ingredients of the UEFA ranking rules suggests that such peer classes are an extrinsic property of the ranking, as obtained in many nonlinear systems under boundary condition constraints.
description: 31 pages, 77 references, 9 figures, comment prepared for Physica Scripta
Effect of Damage Type on Stimulation of Human Excision Nuclease by SWI/SNF Chromatin Remodeling Factor
Creators: name: Hara, R.
name: Sancar, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: To investigate the repair of different types of DNA lesions in chromatin, we prepared mononucleosomes containing an acetylaminofluorene-guanine adduct (AAF-G), a (6-4) photoproduct, or a cyclobutane pyrimidine dimer (CPD) and measured the repair of these lesions by reconstituted 6-factor human excision nuclease. We find that incorporation into nucleosomes inhibits the repair of CPD more severely than repair of the AAF-G adduct and the (6-4) photoproduct. Equally important, we find that SWI/SNF stimulates the removal of AAF-G and (6-4) photoproduct but not of CPD from nucleosomal DNA. These results shed new light on the low rate of repair of CPDs in human cells in vivo.
Evaluation of an Early Childhood Language and Literacy Program
Creators: name: Villar, Anna Lissa Santos
Publisher: name: Zenodo
Year: 2023
Subjects: subject: EYFS, early childhood, language and literacy program
subject: https://files.eric.ed.gov/fulltext/EJ1034914.pdf

description: This study evaluated the early childhood language and literacy program of Dubai Flower Preschool, a group of nurseries and early learning centers with 26 locations in Dubai and Abu Dhabi, United Arab Emirates. The study sought to identify the preschool’s challenges and problems in the implementation of the early years education program; focusing on language and literacy instruction, strategies, and evidence-based practices. It also examined the quality of learning in the preschool, with particular focus on instructional materials, level of content knowledge of the educators, and instructional strategies used in teaching language and literacy, particularly in the UAE setting.
Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs
Creators: name: Wilson, E. M.
name: He, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Coactivator recruitment by activation function 2 (AF2) in the steroid receptor ligand binding domain takes place through binding of an LXXLL amphipathic α-helical motif at the AF2 hydrophobic surface. The androgen receptor (AR) and certain AR coregulators are distinguished by an FXXLF motif that interacts selectively with the AR AF2 site. Here we show that LXXLL and FXXLF motif interactions with steroid receptors are modulated by oppositely charged residues flanking the motifs and charge clusters bordering AF2 in the ligand binding domain. An increased number of charged residues flanking AF2 in the ligand binding domain complement the two previously characterized charge clamp residues in coactivator recruitment. The data suggest a model whereby coactivator recruitment to the receptor AF2 surface is initiated by complementary charge interactions that reflect a reversal of the acidic activation domain-coactivator interaction model.
Solitonic Vortices in Bose-Einstein Condensates
Creators: name: Tylutki, Marek
name: Donadello, Simone
name: Serafini, Simone
name: Pitaevskii, Lev P.
name: Dalfovo, Franco
name: Lamporesi, Giacomo
name: Ferrari, Gabriele
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We analyse, theoretically and experimentally, the nature of solitonic vortices (SV) in an elongated Bose-Einstein condensate. In the experiment, such defects are created via the Kibble-Zurek mechanism, when the temperature of a gas of sodium atoms is quenched across the BEC transition, and are imaged after a free expansion of the condensate. By using the Gross-Pitaevskii equation, we calculate the in-trap density and phase distributions characterizing a SV in the crossover from an elongate quasi-1D to a bulk 3D regime. The simulations show that the free expansion strongly amplifies the key features of a SV and produces a remarkable twist of the solitonic plane due to the quantized vorticity associated with the defect. Good agreement is found between simulations and experiments.
description: 6 pages, 4 figures
Alter(n) als Zukunft. Studienreport
Creators: name: Münch, Anne
name: Lessenich, Stephan
Publisher: name: Universität Bremen
Year: 2022
Subjects: subject: Altern
subject: Alterssoziologie
subject: Zeitsoziologie
subject: Biografieforschung
subject: Pflegeforschung
subject: Grounded Theory
subject: 300

description: Das Forschungsprojekt untersucht das Alter(n) als Zukunftsprojekt und -projektion von Menschen in alternden Gesellschaften. Es setzt auf der Ebene subjektiv-individueller Deutungen, Entwürfe und Strategien zukünftigen Alterns an und richtet sein Erkenntnisinteresse maßgeblich auf die Dimensionen der Altersbilder, der Zeitgestaltung und des Vorsorgehandelns. Es macht sich dabei systematisch die Verknüpfung soziologischer und psychologischer Expertise zunutze und richtet zudem einen kulturvergleichenden Fokus auf drei verschiedene, spät- bzw. postindustrielle Gesellschaften, um die differente Wirkung von sozialstrukturellen, politisch-institutionellen und soziokulturellen Rahmenbedingungen auf das alternsbezogene Zukunftshandeln der Menschen ergründen zu können.
title: Scolarité et maternité
title: un double défi à relever
titleType: Subtitle
Creators: name: Roux, Fanny
Publisher: name: Unknown
Year: 0

description: Cette revue de littérature a pour but d’identifier les différents rôles que peut jouer l’infirmière scolaire dans l’accompagnement d’une adolescente devenant mère. Il me semble pour cela essentiel de s’intéresser aux besoins de ces jeunes filles. Cela m’a donc conduit à me poser la question suivante : « Comment l’infirmière scolaire peut-elle accompagner une adolescente tout au long de sa grossesse et durant le postpartum, en Suisse ? »
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Classical taxonomy and modern methodology
Creators: name: Koste, W
name: Shiel, R. J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Classical rotifer taxonomy and recent approaches are reviewed. -taxonomy (morphology) remains the most widely-used technique, and most prone to subjective errors. Computer technology, and genetic or biochemical methods are not widely available in areas of most need — those with developing limnology programs. Strict adherence to the International Code of Zoological Nomenclature, uniform treatment of ecotypic variation and polymorphism, communication with and between systematists, and establishment of a centralized data base are among the points discussed. A standardized nomenclature is proposed.
Non-thermal dynamics in a spin-1/2 lattice Schwinger model
Creators: name: Gao, Chunping
name: Tang, Zheng
name: Zhu, Fei
name: Zhang, Yunbo
name: Pu, Han
name: Chen, Li
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Local gauge symmetry is intriguing for the study of quantum thermalization breaking. For example, in the high-spin lattice Schwinger model (LSM), the local U(1) gauge symmetry underlies the disorder-free many-body localization (MBL) dynamics of matter fields. This mechanism, however, would not work in a spin-1/2 LSM due to the absence of electric energy in the Hamiltonian. In this paper, we show that the spin-1/2 LSM can also exhibit disorder-free MBL dynamics, as well as entropy prethermalization, by introducing a four-fermion interaction into the system. The interplay between the fermion interaction and U(1) gauge symmetry endows the gauge fields with an effectively disordered potential which is responsible for the thermalization breaking. It induces anomalous (i.e., non-thermal) behaviors in the long-time evolution of such quantities as local observables, entanglement entropy, and correlation functions. Our work offers a new platform to explore emergent non-thermal dynamics in state-of-the-art quantum simulators with gauge symmetries.
H1 Linker Histones Are Essential for Mouse Development and Affect Nucleosome Spacing In Vivo
Creators: name: Fan, Y.
name: Morin-Kensicki, E. M.
name: Magnuson, T. R.
name: Nikitina, T.
name: Zhao, J.
name: Skoultchi, A. I.
name: Woodcock, C. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Most eukaryotic cells contain nearly equimolar amounts of nucleosomes and H1 linker histones. Despite their abundance and the potential functional specialization of H1 subtypes in multicellular organisms, gene inactivation studies have failed to reveal essential functions for linker histones in vivo. Moreover, in vitro studies suggest that H1 subtypes may not be absolutely required for assembly of chromosomes or nuclei. By sequentially inactivating the genes for three mouse H1 subtypes (H1c, H1d, and H1e), we showed that linker histones are essential for mammalian development. Embryos lacking the three H1 subtypes die by mid-gestation with a broad range of defects. Triple-H1-null embryos have about 50% of the normal ratio of H1 to nucleosomes. Mice null for five of these six H1 alleles are viable but are underrepresented in litters and are much smaller than their littermates. Marked reductions in H1 content were found in certain tissues of these mice and in another compound H1 mutant. These results demonstrate that the total amount of H1 is crucial for proper embryonic development. Extensive reduction of H1 in certain tissues did not lead to changes in nuclear size, but it did result in global shortening of the spacing between nucleosomes.
Nucleon D-term in holographic QCD
Creators: name: Fujita, Mitsutoshi
name: Hatta, Yoshitaka
name: Sugimoto, Shigeki
name: Ueda, Takahiro
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The D-term is one of the conserved charges of hadrons defined as the forward limit of the gravitational form factor $D(t)$. We calculate the nucleon's D-term in a holographic QCD model in which the nucleon is described as a soliton in five dimensions. We show that the form factor $D(t)$ is saturated by the exchanges of infinitely many $0^{++}$ and $2^{++}$ glueballs dual to transverse-traceless metric fluctuations on the Wick rotated AdS$_7$ black hole geometry. We refer to this phenomenon as `glueball dominance', in perfect analogy to the vector meson dominance of the electromagnetic form factors. However, the value at vanishing momentum transfer $D(t=0)$ can be interpreted as due to the exchange of pairs of pions and infinitely many vector and axial-vector mesons without any reference to glueballs. We find that the D-term is slightly negative as a result of a cancellation between the isovector and isoscalar meson contributions.
description: 40 pages
title: Polish stabilization program after four months
Creators: name: Malawski, Michal
Year: 2017
Subjects: subject: Osteuropa

description: Das Paper wurde im Rahmen der Ost-West Konferenz (New Economic Relations beween East and West - Conference of the Kreisky Commission and the Swedish Embassy in Vienna, May 17-18, 1990) präsentiert.
description: Typoskript, 5 Blätter
title: L'incontinence urinaire chez les personnes âgées en institution
title: quel accompagnement infirmier ?
titleType: Subtitle
Creators: name: Pignolet, Thi Nhieu
Publisher: name: Unknown
Year: 0
Subjects: subject: INCONTINENCE URINAIRE
subject: PERSONNE AGEE
subject: ETABLISSEMENT MEDICO-SOCIAL
subject: ROLE INFIRMIER

description: L’incontinence urinaire est fréquente chez les personnes âgées vivant en institution. Elle est souvent banalisée et sous-estimée par les professionnels de la santé. Elle a un impact négatif aux niveaux physiques, psychologiques, sociaux et financiers des résidents. Les infirmières ont un rôle important à jouer dans la prise en soins de l’incontinence urinaire afin d’améliorer la qualité de vie des résidents.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Sunspot Catalogue of the Valencia Observatory (1920-1928)
Creators: name: Carrasco, V. M. S.
name: Vaquero, J. M.
name: Aparicio, A. J. P.
name: Gallego, M. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A sunspot catalogue was maintained by the Astronomical Observatory of Valencia University (Spain) from 1920 to 1928. Here we present a machine-readable version of this catalogue (OV catalog or OVc), including a quality control analysis. Sunspot number (total and hemispheric) and sunspot area series are constructed using this catalogue. The OV catalog's data are compared with other available solar data, demonstrating that the present contribution provides the scientific community with a reliable catalogue of sunspot data.
description: 20 pages, 12 figures, accepted for publication in Solar Physics
title: L'approche non pharmacologique en pédiatrie
title: des moyens de gestion de la douleur liée aux procédures douloureuses
titleType: Subtitle
Creators: name: Pereira Neves, Sara
name: Roch, Manon
Publisher: name: Unknown
Year: 0
Subjects: subject: DOULEUR
subject: PEDIATRIE
subject: ANGOISSE
subject: PEUR

description: La douleur provoquée par les soins en pédiatrie est une problématique d’actualité et sa gestion représente encore aujourd’hui un enjeu majeur pour les professionnels. Certaines émotions associées, telles que l’anxiété ou la peur, amplifient le ressenti douloureux et complexifient sa prise en charge. L’approche non pharmacologique est reconnue comme une stratégie complémentaire efficace à l’antalgie médicamenteuse, toutefois ses bénéfices sont souvent sous-estimés. Les situations observées dans la pratique démontrent l’existence de certaines barrières chez les professionnels de la santé et un manque de ressources institutionnelles qui réduisent le recours aux moyens non pharmacologiques.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Nonresonant scattering of relativistic electrons by electromagnetic ion cyclotron waves in Earth's radiation belts
Creators: name: An, Xin
name: Artemyev, Anton
name: Angelopoulos, Vassilis
name: Zhang, Xiaojia
name: Mourenas, Didier
name: Bortnik, Jacob
Publisher: name: arXiv
Year: 2022
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Electromagnetic ion cyclotron waves are expected to pitch-angle scatter and cause atmospheric precipitation of relativistic ($> 1$ MeV) electrons under typical conditions in Earth's radiation belts. However, it has been a longstanding mystery how relativistic electrons in the hundreds of keV range (but $<1$ MeV), which are not resonant with these waves, precipitate simultaneously with those $>1$ MeV. We demonstrate that, when the wave packets are short, nonresonant interactions enable such scattering of $100$s of keV electrons by introducing a spread in wavenumber space. We generalize the quasi-linear diffusion model to include nonresonant effects. The resultant model exhibits an exponential decay of the scattering rates extending below the minimum resonant energy depending on the shortness of the wave packets. This generalized model naturally explains observed nonresonant electron precipitation in the hundreds of keV concurrent with $>1$ MeV precipitation.
Haploinsufficiency of p18INK4c Sensitizes Mice to Carcinogen-Induced Tumorigenesis
Creators: name: Bai, F.
name: Xiong, Y.
name: Pei, X.-H.
name: Godfrey, V. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and thereby retains the growth-suppressive function of Rb family proteins. Mutations in the CDK4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in humans and result in a wide spectrum of tumors in mice. Whereas loss of function of other INK4 genes in mice leads to little or no tumor development, targeted deletion of p18INK4c causes spontaneous pituitary tumors and lymphoma late in life. Here we show that treatment of p18 null and heterozygous mice with a chemical carcinogen resulted in tumor development at an accelerated rate. The remaining wild-type allele of p18 was neither mutated nor silenced in tumors derived from heterozygotes. Hence, p18 is a haploinsufficient tumor suppressor in mice.
title: L'état confusionnel aigu chez l'adulte âgé
title: les interventions de prévention infirmières dans les unités de soins intensifs
titleType: Subtitle
Creators: name: Péquignot, Mélanie
name: Wicky, Pauline
Publisher: name: Unknown
Year: 0

description: L’Etat confusionnel aigu (ECA) est un syndrome aux conséquences néfastes tant pour le patient que pour le système de santé. Il est un phénomène fréquent chez l’adulte âgé hospitalisé mais reste toutefois méconnu par le personnel soignant et très souvent sous évalué. La prise en charge d’un adulte âgé dans un milieu de soins aigus représente un enjeu de taille pour l’infirmier. Le milieu des soins intensifs, en raison de de ses multiples spécificités, semble être le milieu le plus à risque pour développer un ECA.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
title: Preparing for the storm?
Creators: name: Héthy, Lajos
Year: 2017
Subjects: subject: Osteuropa

description: Auf der Rückseite der letzten Seite befinden sich Konferenz-Notizen von Josef Steindl. - Das Paper wurde im Rahmen der Ost-West Konferenz (New Economic Relations beween East and West - Conference of the Kreisky Commission and the Swedish Embassy in Vienna, May 17-18, 1990) präsentiert.
description: Typoskript, 7 Blätter, paginiert, 2-7
title: Défi infirmier
title: favoriser l'engagement des patients atteints de psychose débutante
titleType: Subtitle
Creators: name: Mansiat, Cindy
name: Rapin, Méris
name: Tinghir, Sevan
Publisher: name: Unknown
Year: 0
Subjects: subject: ACCOMPAGNEMENT
subject: PSYCHOSE
subject: SOINS INFIRMIERS EN PSYCHIATRIE
subject: ROLE INFIRMIER

description: 3% de la population présente un épisode psychotique au cours de sa vie, dont 80% entre 15 et 30 ans. La fin de l’adolescence et le début de l’âge adulte sont synonymes de multiples bouleversements et changements ; ces populations sont donc particulièrement vulnérables. La durée moyenne entre les premiers symptômes psychotiques et le début du traitement est de un à deux ans. La psychose débutante est définie par la période comprenant la phase prodromique jusqu’à la 5ème année suivant le premier épisode psychotique. Favoriser rapidement l’engagement dans les soins de ces jeunes patients est très important, car une prise en charge précoce permet de soulager leur détresse. En plus, nous avons appris que 40% des patients atteints de psychose débutante interrompent leur médication pendant les neufs premiers mois, ce qui fait que les risques de rechutes ne sont pas négligeables.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Probing the structural evolution along the fission path in the superheavy nucleus $^{256}$Sg
Creators: name: Li, Ting-Ting
name: Wang, Hua-Lei
name: Zhang, Zhen-Zhen
name: Liu, Min-Liang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The evolution of structure property along the fission path in the superheavy nucleus $^{256}$Sg is predicted through the multi-dimensional potential-energy(or Routhian)-surface calculations,in which the phenomenological deformed Woods-Saxon potential is adopted. Calculated nuclear deformations and fission barriers for $^{256}_{106}$Sg$_{150}$ and its neighbors, e.g., $^{258,260}$Sg, $^{254}$Rf and $^{252}$No are presented and compared with other theoretical results. A series of energy maps and curves are provided and used to evaluate the corresponding shape-instability properties, especially in the directions of triaxial $γ$ and different hexadecapole deformations (e.g., $α_{40}$, $α_{42}$ and $α_{44}$). It is found that the triaxial deformation may help the nucleus bypass the first fission-barrier of the axial case. After the first minimum in the nuclear energy surface, the fission pathway of the nucleus can be affected by $γ$ and hexadecapole deformation degrees of freedom. In addition, microscopic single-particle structure, pairing and Coriolis effects are briefly investigated and discussed.
description: 26 pages, 10 figures
Monopole correlations in holographically flavored liquids
Creators: name: Iqbal, Nabil
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Many-body systems with a conserved U(1) current in (2+1) dimensions may be probed by weakly gauging this current and studying correlation functions of magnetic monopole operators in the resulting dynamical gauge theory. We study such monopole correlations in holographic liquids with fundamental flavor, where the monopole operator is dual to a magnetically charged particle in the bulk. In charge-gapped phases the monopole operator is expected to condense. We show that this condensation is holographically dual to the capping off of the bulk flavor brane and compute the monopole condensate. We argue that from the lower-dimensional point of view this may be understood as a simple example of confinement of a gauge field in the bulk. In a compressible finite-density phase we present a novel calculation of the monopole correlation in space and time: the correlation is power law in time but is Gaussian in space due to interaction with the background charge density.
description: 13 pages + appendices, 8 figures
Multimodal Attention-based Deep Learning for Alzheimer's Disease Diagnosis
Creators: name: Golovanevsky, Michal
name: Eickhoff, Carsten
name: Singh, Ritambhara
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Alzheimer's Disease (AD) is the most common neurodegenerative disorder with one of the most complex pathogeneses, making effective and clinically actionable decision support difficult. The objective of this study was to develop a novel multimodal deep learning framework to aid medical professionals in AD diagnosis. We present a Multimodal Alzheimer's Disease Diagnosis framework (MADDi) to accurately detect the presence of AD and mild cognitive impairment (MCI) from imaging, genetic, and clinical data. MADDi is novel in that we use cross-modal attention, which captures interactions between modalities - a method not previously explored in this domain. We perform multi-class classification, a challenging task considering the strong similarities between MCI and AD. We compare with previous state-of-the-art models, evaluate the importance of attention, and examine the contribution of each modality to the model's performance. MADDi classifies MCI, AD, and controls with 96.88% accuracy on a held-out test set. When examining the contribution of different attention schemes, we found that the combination of cross-modal attention with self-attention performed the best, and no attention layers in the model performed the worst, with a 7.9% difference in F1-Scores. Our experiments underlined the importance of structured clinical data to help machine learning models contextualize and interpret the remaining modalities. Extensive ablation studies showed that any multimodal mixture of input features without access to structured clinical information suffered marked performance losses. This study demonstrates the merit of combining multiple input modalities via cross-modal attention to deliver highly accurate AD diagnostic decision support.
description: 11 pages, 5 figures
Histone Deacetylase 1/mSin3A Disrupts Gamma Interferon-Induced CIITA Function and Major Histocompatibility Complex Class II Enhanceosome Formation
Creators: name: Zika, E.
name: Ting, J. P.-Y.
name: Greer, S. F.
name: Zhu, X.-S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The class II transactivator (CIITA) is a master transcriptional regulator of major histocompatibility complex class II (MHC-II) promoters. CIITA does not bind DNA, but it interacts with the transcription factors RFX5, NF-Y, and CREB and associated chromatin-modifying enzymes to form an enhanceosome. This report examines the effects of histone deacetylases 1 and 2 (HDAC1/HDAC2) on MHC-II gene induction by gamma interferon (IFN-γ) and CIITA. The results show that an inhibitor of HDACs, trichostatin A, enhances IFN-γ-induced MHC-II expression, while HDAC1/HDAC2 inhibits IFN-γ- and CIITA-induced MHC-II gene expression. mSin3A, a corepressor of HDAC1/HDAC2, is important for this inhibition, while NcoR, a corepressor of HDAC3, is not. The effect of this inhibition is directed at CIITA, since HDAC1/HDAC2 reduces transactivation by a GAL4-CIITA fusion protein. CIITA binds to overexpressed and endogenous HDAC1, suggesting that HDAC and CIITA may affect each other by direct or indirect association. Inhibition of HDAC activity dramatically increases the association of NF-YB and RFX5 with CIITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter. These results suggest a model where HDAC1/HDAC2 affect the function of CIITA through a disruption of MHC-II enhanceosome and relevant coactivator-transcription factor association and provide evidence that CIITA may act as a molecular switch to modulate MHC-II transcription by coordinating the functions of both histone acetylases and HDACs.
title: L'évaluation clinique infirmière
title: gage de sécurité et de qualité des soins
titleType: Subtitle
Creators: name: Mabica, Sarah
name: Marbacher, Esther
Publisher: name: Unknown
Year: 0
Subjects: subject: EVALUATION CLINIQUE
subject: SOINS INFIRMIERS
subject: GESTION DES RISQUES

description: Cette revue de littérature s'intéresse aux éléments influençant l'évaluation clinique infirmière et la réduction des complications ainsi que du taux de mortalité par Failure to Rescue (FRT) dans les services de médecine et de chirurgie générale.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Experimental consequences at high temperatures of quantum critical points
Creators: name: Freitas, D. C.
name: Rodière, P.
name: Núñez, M.
name: Marcus, J.
name: Gay, F.
name: Continentino, M. A.
name: Núñez-Regueiro, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the Cr_(1-x) Re_x phase diagram finding that its phase transition temperature towards an antiferromagnetic order T_N follows a quantum [(x_c-x)/x_c ]^ψ law, with ψ=1/2, from the quantum critical point (QCP) at x_c=0.25 up to T_N=600K. We compare this system to others in order to understand why this elemental material is affected by the QCP up to such unusually high temperatures. We determine a general criterion for the crossover, as function of an external parameter such as concentration, from the region controlled solely by thermal fluctuations to that where quantum effects become observable. The properties of materials with low coherence lengths will thus be altered far away from the QCP.
title: La préparation de la personne âgée au placement en EMS
title: une possibilité ou une nécessité dans la prise en soins infirmière?
titleType: Subtitle
Creators: name: Heuzé, Leslie
name: Jaques, Lise
Publisher: name: Unknown
Year: 0
Subjects: subject: VIEILLISSEMENT
subject: PERSONNE AGEE
subject: ETABLISSEMENT MEDICO-SOCIAL
subject: ACCOMPAGNEMENT

description: Le vieillissement de la population est une problématique actuelle. Il y a en effet un accroissement de la population âgée depuis quelques années, et avec celui-ci une augmentation des besoins en soins. Ce phénomène va encore s’intensifier ces prochaines décennies. La question du placement en établissement médico-social (EMS) risque ainsi d’être de plus en plus fréquente. Souvent représenté comme une transition complexe, le placement est généralement redouté par les personnes âgées. Nous pensons donc qu’une préparation au placement est nécessaire et que celle-ci peut relever du rôle infirmier. Notre question de recherche est alors : quelles interventions infirmières pouvons-nous mettre en place dans l’accompagnement des personnes âgées à domicile afin de favoriser la transition du placement en établissement médico-social ?
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment
Creators: name: Roig, Marta Bofill
name: Melis, Guadalupe Gómez
name: Posch, Martin
name: Koenig, Franz
Publisher: name: arXiv
Year: 2022
Subjects: subject: Methodology (stat.ME)
subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints are widely chosen as the primary endpoint. Despite being commonly used, composite endpoints entail challenges in designing and interpreting results. Given that the components may be of different relevance and have different effect sizes, the choice of components must be made carefully. Especially, sample size calculations for composite binary endpoints depend not only on the anticipated effect sizes and event probabilities of the composite components, but also on the correlation between them. However, information on the correlation between endpoints is usually not reported in the literature which can be an obstacle for planning of future sound trial design. We consider two-arm randomized controlled trials with a primary composite binary endpoint and an endpoint that consists only of the clinically more important component of the composite endpoint. We propose a trial design that allows an adaptive modification of the primary endpoint based on blinded information obtained at an interim analysis. We consider a decision rule to select between a composite endpoint and its most relevant component as primary endpoint. The decision rule chooses the endpoint with the lower estimated required sample size. Additionally, the sample size is reassessed using the estimated event probabilities and correlation, and the expected effect sizes of the composite components. We investigate the statistical power and significance level under the proposed design through simulations. We show that the adaptive design is equally or more powerful than designs without adaptive modification on the primary endpoint. The targeted power is achieved even if the correlation is misspecified while maintaining the type 1 error. We illustrated the proposal by means of two case studies.
HoxB5 Is an Upstream Transcriptional Switch for Differentiation of the Vascular Endothelium from Precursor Cells
Creators: name: Patterson, C.
name: Moser, M.
name: Bautch, V. L.
name: Wu, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Endothelial cells differentiate from mesoderm-derived precursors to initiate the earliest events in vascular development. Although the signaling events that regulate the successive steps of vascular development are known in some detail, the transcriptional processes that regulate the first steps in vasculogenesis are not well defined. We have studied the regulatory mechanisms of flk1 expression as a model to understand the upstream events in endothelial cell differentiation, since flk1 is the earliest marker of endothelial precursors. Using a variety of biochemical approaches, we identified a cis-acting element in the first intron of the flk1 gene that is required for endothelium-dependent expression in transgenic reporter gene assays. Using the yeast one-hybrid system, we identified HoxB5 as the transcription factor that binds this cis-acting element, the HoxB5-binding element (HBE). HoxB5 mRNA colocalized with flk1 expression in differentiating embryoid bodies, and HoxB5 potently transactivated the flk1 promoter in an HBE-dependent fashion in transient-transfection assays. Overexpression of HoxB5 led to expansion of flk1+ angioblasts in differentiating embryoid bodies and increased the number of PECAM (platelet-endothelial cell adhesion molecule)-positive primitive blood vessels. HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors.
Mass-corrections to double-Higgs production & TopoID
Creators: name: Grigo, Jonathan
name: Hoff, Jens
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider power corrections due to a finite top quark mass M_t to the production of a Higgs boson pair within the Standard Model at next-to-leading order (NLO) in QCD. Previous calculations for this process and at this precision were done in the limit of an inifinitely heavy top quark. Our results for the inclusive production cross section at NLO include terms up to O(1/M_t^12). We present the Mathematica package TopoID which for arbitrary processes aims to perform the necessary steps from Feynman diagrams to unrenormalized results expressed in terms of master integrals. We employ it for advancing in this process towards next-to-next-to-leading order (NNLO) where further automatization is needed.
description: Contribution to the proceedings of Loops and Legs in Quantum Field Theory, 27 April - 2 May 2014, Weimar, Germany
Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells
Creators: name: Kabakov, A. E.
name: Patterson, C.
name: Kanon, B.
name: Salomons, F. A.
name: Kampinga, H. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: CHIP is a cochaperone of Hsp70 that inhibits Hsp70-dependent refolding in vitro. However, the effect of altered expression of CHIP on the fate of unfolded proteins in mammalian cells has not been determined. Surprisingly, we found that overexpression of CHIP in fibroblasts increased the refolding of proteins after thermal denaturation. This effect was insensitive to geldanamycin, an Hsp90 inhibitor, and required the tetratricopeptide repeat motifs but not the U-box domain of CHIP. Inhibition of Hsp70 chaperone activity abolished the effects of CHIP on protein folding, indicating that the CHIP-mediated events were Hsp70 dependent. Hsp40 competitively inhibited the CHIP-dependent refolding, which is consistent with in vitro data indicating that these cofactors act on Hsp70 in the ATP-bound state and have opposing effects on Hsp70 ATPase activity. Consistent with these observations, CHIP overexpression did not alter protein folding in the setting of ATP depletion, when Hsp70 is in the ADP-bound state. Concomitant with its effects on refolding heat-denatured substrates, CHIP increased the fraction of nascent chains coimmunoprecipitating with Hsc70, but only when sufficient ATP was present to allow Hsp70 to cycle rapidly. Our data suggest that, consistent with in vitro studies, CHIP attenuates the Hsp70 cycle in living cells. The impact of this effect on the fate of unfolded proteins in cells, however, is different from what might be expected from the in vitro data. Rather than resulting in inhibited refolding, CHIP increases the folding capacity of Hsp70 in eukaryotic cells.
The Star Formation Relation for Regions in the Galactic Plane: The Effect of Spatial Resolution
Creators: name: Vutisalchavakul, Nalin
name: Evans, Neal J.
name: Battersby, Cara
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We examined the relations between molecular gas surface density and star formation rate surface density in a 11 square degree region of the Galactic Plane. Dust continuum at 1.1 mm from the Bolocam Galactic Plane Survey and 22 micron emission from the WISE All-sky survey were used as tracers of molecular gas and star formation rate, respectively, across Galactic longitude of 31.5 > l > 20.5 and Galactic latitude of 0.5 > b > -0.5. The relation was studied over a range of resolutions from 33 arcsecond to 20 arcminute by convolving images to larger scales. The pixel-by-pixel correlation between 1.1 mm and 22 micron increases rapidly at small scales and levels off at the scale of 5 - 8 arcminute. We studied the star formation relation based on pixel-by-pixel analysis and 1.1 mm and 22 micron peaks analysis. The star formation relation was found to be nearly linear with no significant changes in the form of the relation across all spatial scales and lie above the extragalactic relation from Kennicutt (1998). The average gas depletion time is approximately 200 Myr and does not change significantly at different scales, but the scatter in the depletion time decreases as the scale increases.
description: 23 pages, 14 figures, accepted for publication in ApJ
title: Les infections nosocomiales néonatales
title: quand l'infirmière a une place centrale dans la prévention
titleType: Subtitle
Creators: name: Hayoz, Mathilde
name: Moser, Olivia
Publisher: name: Unknown
Year: 0
Subjects: subject: ROLE INFIRMIER
subject: PREVENTION
subject: INFECTION NOSOCOMIALE
subject: NEONATOLOGIE
subject: NOUVEAU-NE
subject: SOINS INTESIFS

description: L’objectif de cette revue de littérature est de répondre au questionnement clinique suivant : quelles sont les mesures de prévention que l’infirmière peut mettre en place afin de diminuer le taux d’infections nosocomiales lors de procédures invasives auprès des nouveau-nés dans un service de soins intensifs de néonatologie ?
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Germination and seedling emergence in Diplachne fusca: a semi-aquatic weed of rice fields
Creators: name: McIntyre, S
name: Mitchell, D. S
name: Ladiges, P. Y
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

(1) The native grass Diplachne fusca has become and important weed in rice fields in temperate Australia since rice cultivation began there in 1922. Field and glasshouse experiments were conducted to examine the population dynamics of D. fusca in rice fields and to develop strategies for its control.(2) D. fusca can develop a persistent seed bank, with 48 000 seeds m-2 (0-6 cm depth) measured at one site 18 months after the last seed input. No seedlings emerged from depths >10 mm whereas 60% of seedlings arose from seed lying on the soil surface. Emergence was strongly inhibited by the presence of litter or living pasture plants. The highest seedling density was on bare ground (1480 m-2), but this represented < 5% of the seed bank.(3) The patterns of seedling emergence were similar to those observed after experimentally storing seeds for 7.5 months in a range of semi-natural and artificial storage conditions. High dormancy levels were found in seed which had been stored dry and exposed to natural weather conditions. Storage in water gave the highest germination, but a single drying cycle reduced germination from 44% to 10%. Darkness inhibited germination of non-dormant seed.(4) The development of dormant seed reserves in the soil and the dependence on open areas for regeneration are features that D. fusca shares with many arable weeds and colonizing species. These features, as well as the loss of seed dormancy with prolonged flooding, are interpreted as adaptations to intermittent wetlands, the natural habitat of D. fusca prior to its invasion of rice fields.