cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of docetaxel-loaded PEG–PLA nanoparticles using surfactant-free method for controlled release studies
Creators: name: Prajna Mishra
name: Dey, Ratan Kumar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Docetaxel (DTX)-loaded poly(ethylene glycol)–poly(D,L-lactide) is prepared by nanoprecipitation method in the absence of any surfactants. The average particle size of the copolymer was found to be 101 nm. The drug entrapment efficiency (%) and drug loading (%) of polymer were found to be 9.471 ± 0.047 and 94.71 ± 0.466, respectively. The in vitro drug release characteristics show the controlled release of 98% of docetaxel in 72 h. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and apoptosis measured in terms of cleaved Poly(ADP-ribose) Polymerase (PARP) and cleaved caspase-3 protein expression shows that the copolymer has better cytotoxicity effect and apoptosis in comparison to free DTX in HeLa cells.
ПРИВЕРЖЕННОСТЬ ОТДЕЛЬНЫХ ГРУПП НАСЕЛЕНИЯ К ВАКЦИНОПРОФИЛАКТИКЕ ДЕТЕЙ
Creators: name: Хакимова Резеда Фидаиловна
name: Васильева Алла Александровна
name: Хакимова Миляуша Рашитовна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: вакцинация
дети
Национальный календарь профилактических прививок
отношение к вакцинации
медицинский отвод от вакцинации

description: Целью исследования явилось изучение отношения к вакцинопрофилактике, в том числе медицинских работников, и определение причин медицинских отводов от вакцинации. Методы исследования: проведен online-опрос 350 респондентов (средний возраст 31 год) по разработанной анкете и анализ клинико-анамнестических данных 148 детей в возрасте от 0 до 7 лет. Результаты: установлена высокая частота отрицательного отношения к вакцинации среди респондентов (около 1/3 опрошенных). При этом отмечено понимание необходимости повышения информированности населения в отношении проблемы вакцинопрофилактики. Профессия, связанная с медициной, влияет на формирование отношения к вакцинации: среди медицинских работников частота отрицательного отношения в 2 раза ниже. Выявлена прямая зависимость от возраста ребенка частоты необоснованных медицинских отводов от вакцинации, что свидетельствует о необходимости формирования компетенций в области вакцинопрофилактики при переподготовке врачей.
Review Essay: Eleonora Stoppino, Genealogies of Fiction: Women Warriors and the Dynastic Imagination in the Orlando Furioso
Creators: Cavallo, Jo Ann
Publisher: name: Columbia University
Year: 2012
Subjects: Literature
Women's studies

description: Book review of Genealogies of Fiction: Women Warriors and the Dynastic Imagination in the Orlando Furioso by Eleonora Stoppino
Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes
Creators: name: Li, Hong Xu
name: Eunji Jo
name: Chang-Seon Myung
name: Kim, Young Ho
name: Yang, Seo Young
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8–9 and 17–18 exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation.
MOESM6 of Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study
Creators: name: Chauvin, Anthony
name: Ravaud, Philippe
name: Moher, David
name: Schriger, David
name: Hopewell, Sally
name: Shanahan, Daniel
name: Alam, Sabina
name: Baron, Gabriel
name: Regnaux, Jean-Philippe
name: Crequit, Perrine
name: Martinez, Valeria
name: Riveros, Carolina
name: Cleach, Laurence
name: Recchioni, Alessandro
name: Altman, Douglas
name: Boutron, Isabelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 6. The COBPeer tool. Details of each domains evaluated by early career researchers with COBPeer tool.
АЛЛЕРГИЯ К БЕЛКАМ КОРОВЬЕГО МОЛОКА КАК ТРИГГЕР АНАФИЛАКСИИ У ДЕТЕЙ
Creators: name: Лепешкова Татьяна Сергеевна
name: Бельтюков Евгений Кронидович
name: Царькова Софья Анатольевна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: Ключевые слова: анафилаксия на продукты
дети
продукты
жизнеугрожающие реакции
адреналин

description: Проблема пищевой аллергии в последние годы становится все более актуальной. Симптомы пищевой анафилаксии, как наиболее тяжелой формы ПА, возникают молниеносно или очень быстро, затрагивают несколько систем организма человека, нарушая при этом их нормальные функции и становясь в единичных случаях причиной фатальных исходов. Возможность избежать подобных острых эпизодов аллергии может быть обеспечена полным прекращением употребления продукта, ранее вызывавшего пищевую анафилаксию. В статье представлены последние данные литературы по аллергии и пищевой анафилаксии на белки коровьего молока, которые проиллюстрированы клиническими примерами. В ряде представленных клинических случаев, именно неверные действия взрослых (рекомендации медицинских специалистов, действия родителей) способствовали усилению степени чувствительности к молочным протеинам и возникновению пищевой анафилаксии у описанных детей. Цель работы — представить клинические случаи тяжелых проявлений аллергии к белкам коровьего молока и значимость углубленного аллергологического обследования (ISAC, ImmunoCAP) с целью дальнейшей профилактики новых эпизодов пищевой анафилаксии у детей.
Analyse des propriétés mécaniques et microstructurales des mortiers riches en MgO
Creators: name: Matamba, Raphael
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Les matières premières utilisées pour la fabrication du Ciment Portland sont principalement le calcaire, l'argile et d'autres matériaux à base de Ca, Al, Fe et Si. Souvent, les matériaux calcaires dolomitiques sont évités en raison de problèmes d’hydratation et d'expansion de MgO. Il n'y a pas une large littérature publiée sur les problèmes d'expansion des mortiers riches en MgO car c’est le calcaire qui est largement utilisé pour la fabrication de ciment au cours d’expériences de laboratoire. Dans ce travail, la microstructure et les propriétés mécaniques d'un mortier à base de liant riche en MgO sont évaluées et comparées à celles des mortiers à base du liant hydraulique (XHA 10).Des échantillons à faciès dolomitique ont été prélevés dans la région du Kasaï (Centre de la RD Congo) et un liant riche en MgO a été mise au point. Les analyses chimiques (XRF), minéralogiques (DRX, analyses thermiques et la microscopie électronique), ont permis d’évaluer les propriétés mécaniques et microstructurales du mortier à base de ce liant. Les essais ont été réalisés sur des mortiers à 28, 90 et 210 jours. Les résultats ont montré que les problèmes d‘expansion des mortiers riches en MgO ne dépendent que de la microstructure de cristaux de dolomites de la matière première utilisée.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming
Creators: name: Xiang, Ge
name: Yang, Liang
name: Long, Qi
name: Keshi Chen
name: Haite Tang
name: Wu, Yi
name: Zihuang Liu
name: Yanshuang Zhou
name: Juntao Qi
name: Lingjun Zheng
name: Wenbo Liu
name: Zhongfu Ying
name: Weimin Fan
name: Hongyan Shi
name: Hongmei Li
name: Xiaobing Lin
name: Gao, Mi
name: Jinglei Liu
name: Feixiang Bao
name: Linpeng Li
name: Lifan Duan
name: Li, Min
name: Xingguo Liu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogramming have not been extensively explored. We show that both SKP/SKO (Sox2, Klf4, Pou5f1/Oct4) and SKPM/SKOM (SKP/SKO plus Myc/c-Myc) reprogramming lead to decreased mitochondrial mass but with different kinetics and by divergent pathways. Rapid, MYC/c-MYC-induced cell proliferation may function as the main driver of mitochondrial decrease in SKPM/SKOM reprogramming. In SKP/SKO reprogramming, however, mitochondrial mass initially increases and subsequently decreases via mitophagy. This mitophagy is dependent on the mitochondrial outer membrane receptor BNIP3L/NIX but not on mitochondrial membrane potential (ΔΨm) dissipation, and this SKP/SKO-induced mitophagy functions in an important role during the reprogramming process. Furthermore, endosome-related RAB5 is involved in mitophagosome formation in SKP/SKO reprogramming. These results reveal a novel role of mitophagy in reprogramming that entails the interaction between mitochondria, macroautophagy/autophagy and endosomes.
Instructed Task Demands and Utilization of Action Effect Anticipation
Creators: name: Gaschler, Robert
name: Nattkemper, Dieter
Publisher: name: Humboldt-Universität zu Berlin
Year: 2012
Subjects: subject: action effect
subject: effect anticipation
subject: stimulus based
subject: intention based
subject: instruction manipulation
subject: 150 Psychologie

description: Automatic acquisition of action effect associations may serve as a parsimonious account of how people acquire the basis for intentionally controlled action. However, recent research suggests that learning or the expression of action effect links might depend on whether task demands impose either a stimulus based mode of action control or an intention based action control mode. In the current study we develop a paradigm that allows the mode of action control to be varied via instructions while keeping stimuli identical. Participants were to respond to the location of a cloud of dots. Their actions were followed by predictable visual effects, either consistently congruent or incongruent with the location of the action. In Experiment 1, a displaced new cloud of random dots was presented as a spatial action effect. In Experiment 2 an arrow was presented as effect with a pointing direction congruent or incongruent to the response position. The location of the stimulus in the reference frame was easy to detect in some of the trials while the location of the cloud of dots was completely ambiguous in others. The instruction manipulation targeted the latter trials, suggesting to one group of participants to freely choose a key in a difficult trial, while asking another group to react to their spontaneous impression in the event of a difficult stimulus. In this way, we aimed at rendering actions either as stimulus driven or internally generated. By this we could investigate how effect anticipation changed with practice depending on action mode. We employed the impact of action effect compatibility on speed and choice of action as a measure for action effect anticipation. Our results suggest that action effect associations can be acquired when instructions suggest stimulus based action control or intention based action control. Instructions aiming at the mode of task processing can influence when and how action effect links influence behavior.
Review of  Immigration and Integration in Urban Communities: Renegotiating the City, ed. Lisa Hanley, Blair Ruble, and Allison Garland
Creators: Irazabal Zurita, Clara E.
Publisher: name: Columbia University
Year: 2010
Subjects: City planning

description: This book challenges the prevailing, counterpoising paradigms of immigration studies and integration strategies -- multiculturalism and assimilationism -- by noting that host communities are not as static and migrants are constantly evolving, reacting and adapting to each other.
Review essay "The Sport of Kings and the Kings of Crime: Horse Racing, Politics, and Organized Crime in New York, 1865-1913" by Steven A. Reiss. Syracuse, NY: Syracuse University Press, 2011
Creators: Steenshorne, Jennifer E.
Publisher: name: Columbia University
Year: 2015
Subjects: Horse racing
Horse racing--Betting
Horse racing--Social aspects

description: Review essay of Steven Reiss's study of horse racing in New York. "Sport of Kings" traces the rise of horseracing in New York, its emerging dominance as a sport, efforts to police the sport, and the concurrent rise of legal and illegal gambling, set against the backdrop of Gilded Age politics and Progressive reform.
Review of "Make/Believing the World(s): Toward a Christian Ontological Pluralism," by Mark S. McLeod-Harrison
Creators: Knitter, Paul
Publisher: name: Columbia University
Year: 2010
Subjects: Religion

description: McLeod-Harrison's volume presents a well-honed, intricate, somewhat overextended argument for a simple but bold claim: in knowing reality, we give shape to reality.
Review of A Short History of the Mughal Empire by Michael Fisher
Creators: Ahmed Asif, Manan
Publisher: name: Columbia University
Year: 2017
Subjects: Historiography
History

description: A Short History of the Mughal Empire. By Michael Fisher. London: I.B. Tauris, 2015. 256 pp. ISBN: 9781848858725 (cloth, also available in paper).
Review of Biomedical Image Processing. Edited by Thomas Martin Deserno. Springer-Verlag New York, LLC; 2011, 595 pages
Creators: Ciaccio, Edward J.
Publisher: name: Columbia University
Year: 2011
Subjects: Biomedical engineering

description: This article is a review of the book: 'Biomedical Image Processing', by Thomas M. Deserno, which is published by Springer-Verlag. Salient information that will be useful to decide whether the book is relevant to topics of interest to the reader, and whether it might be suitable as a course textbook, are presented in the review. This includes information about the book details, a summary, the suitability of the text in course and research work, the framework of the book, its specific content, and conclusions.
Review of Alexander Markus Schilling, Mögliches, Unwahrscheinliches, Fabelhaftes...
Creators: Riedel, Dagmar A.
Publisher: name: Columbia University
Year: 2015
Subjects: Middle Ages
Civilization, Western--Middle Eastern influences
Germanic peoples--Religion
History

description: This slim paperback presents the text of a lecture (p. 7), in which Schilling, a specialist of Christian Arabic literature at the University of Jena, suggests that the Carmelite friar John of Hildesheim (d. 1375; cf. VL2, 4, cols. 638–647) could have been familiar with the Coptic Kitāb al-majāll (Book of the rolls).
D4.4: InnWater Governance Platform V1
Creators: name: Ribalta Gené, Marc
Publisher: name: Zenodo
Year: 2024

description: The objective of this deliverable is to explain all the initial decisions regarding the design and development of the platform during the first 12 months (M6-M18). It covers everything from the requirements identified in discussions with stakeholders and end users to the decisions about the platform architecture design that will ensure the correct functioning of the software. Therefore, this document contains information prior to the technical implementation of the platform, right now ongoing, but which will be reported in the future D4.5 “InnWater Governance platform V2”.
Additional file 1 of Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study
Creators: name: Zhang, Hui
name: Hao, Meng
name: Hu, Zixin
name: Li, Yi
name: Jiang, Xiaoyan
name: Wang, Jiucun
name: Jin, Li
name: Liu, Zuyun
name: Wang, Xiaofeng
name: Sun, Xuehui
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplemental Table S1. Characteristics of the study population stratified by quartiles of NLR levels at baseline. Supplemental Table S2. Characteristics of the study population stratified by quartiles of PLR levels at baseline. Supplemental Table S3. Characteristics of the study population stratified by quartiles of SII levels at baseline. Supplemental Table S4. Association of immunity markers with risk of frailty at baseline. Supplemental Table S5. Association of immunity markers with risk of frailty among all individuals at baseline. Supplemental Table S6. Association of immunity markers with risk of frailty among individuals without comorbidity at baseline
Chemical analysis and antiviral activity evaluation of Baccharis anomala
Creators: name: Venturi, Caroline Rita
name: Srgio Augusto De Loreto Bordignon
name: Roehe, Paulo Michel
name: Jarbas Alves Montanha
name: Cibulski, Samuel Paulo
name: Gosmann, Grace
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Hematology

description: The chemical composition and antiviral activity of aqueous extract from Baccharis anomala was studied by bioactivity-guided fractionation. Ethanol precipitation and fractionation by molecular permeation allowed the separation of the anti-herpes simplex virus 1 (HSV-1) active fraction from aqueous extract (Fraction B). Natural Product Reagent A, FeCl3 and thin-layer chromatography indicated the presence of phenolic compounds in the aqueous extract. Fraction B showed pronounced antiviral activity when tested with HSV-1 strains VR733/ATCC and Acyclovir-resistant 29-R, displaying virucidal but not virustatic activity.
Review of Christian Lee Novetzke's The Quotidian Revolution: Vernacularization, Religion, and the Premodern Public Sphere in India
Creators: Ahmed Asif, Manan
Publisher: name: Columbia University
Year: 2018
Subjects: History
Religion
Social conditions
Marathi literature

description: Review of Christian Lee Novetzke. The Quotidian Revolution: Vernacularization, Religion, and the Premodern Public Sphere in India., in The American Historical Review, Volume 123, Issue 1, 1 February 2018, Pages 201–202.
MOESM7 of Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study
Creators: name: Chauvin, Anthony
name: Ravaud, Philippe
name: Moher, David
name: Schriger, David
name: Hopewell, Sally
name: Shanahan, Daniel
name: Alam, Sabina
name: Baron, Gabriel
name: Regnaux, Jean-Philippe
name: Crequit, Perrine
name: Martinez, Valeria
name: Riveros, Carolina
name: Cleach, Laurence
name: Recchioni, Alessandro
name: Altman, Douglas
name: Boutron, Isabelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 7. Information for participants. The invitation letter received by the early career researchers.
Review of Daniel Fanous. Taught by God: Making Sense of the Difficult Sayings of Jesus.
Creators: Trostyanskiy, Sergey
Publisher: name: Columbia University
Year: 2010
Subjects: Religion

description: Dr. Daniel Fanous, an Orthodox independent researcher with degrees in medicine and engineering, presents to the reader the most profound sayings of Jesus and attempts to decipher their meanings by contextualizing them within the framework of first-century Mediterranean culture. Taking into account that the sayings represent God’s speech and are “intrinsic manifestations of Jesus’ entire life and mission” the author empathetically insists on the necessity of placing the sayings into their proper historical and intellectual contexts to extract their significance. He does so because the un-contextualized reading of ancient sources leads to the fusion of ancient and modern horizons and results in misinterpretations at best and to significant doctrinal distortions of the original meaning at worst.
BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during Three Factors Induced Somatic Cell Reprogramming
Creators: name: Xiang, Ge
name: Yang, Liang
name: Long, Qi
name: Keshi Chen
name: Haite Tang
name: Wu, Yi
name: Zihuang Liu
name: Yanshuang Zhou
name: Juntao Qi
name: Lingjun Zheng
name: Wenbo Liu
name: Zhongfu Ying
name: Weimin Fan
name: Hongyan Shi
name: Hongmei Li
name: Xiaobing Lin
name: Gao, Mi
name: Jinglei Liu
name: Feixiang Bao
name: Linpeng Li
name: Lifan Duan
name: Li, Min
name: Xingguo Liu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Induced pluripotent stem cells (iPSCs) have less and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogramming have not been extensively explored. We show that both SKP/SKO (Sox2, Klf4, Pou5f1/Oct4) and SKPM/SKOM (SKP/SKO plus Myc/c-Myc) reprogramming lead to decreased mitochondrial mass but with different kinetics and by divergent pathways. Rapid, MYC/c-MYC-induced cell proliferation may function as the main driver of mitochondrial decrease in SKPM/SKOM reprogramming. In SKP/SKO reprogramming, however, mitochondrial mass initially increases and subsequently decreases via mitophagy. This mitophagy is dependent on the mitochondrial outer membrane receptor BNIP3L/NIX but not on mitochondrial membrane potential (ΔΨm) dissipation, and this SKP/SKO-induced mitophagy functions in an important role during the reprogramming process. Furthermore, endosome-related RAB5 is involved in mitophagosome formation in SKP/SKO reprogramming. These results reveal a novel role of mitophagy in reprogramming that entails the interaction between mitochondria, macroautophagy/autophagy and endosomes.
Review of Evan Jones, ed., Intimate Voices: The Twentieth CenturyString Quartet (Rochester University Press, 2009)
Creators: Kozak, Mariusz S.
Publisher: name: Columbia University
Year: 2012
Subjects: Music

description: This two-volume, 750-page tome, edited by Evan Jones, is a major contribution both to music analysis and to scholarship on the string quartet. It comprises essays by some of today’s leading theorists, each one taking on a single composer and closely examining his or her approach to the string quartet. As such, it is truly a scholarly tour de force, a monumental assembly--both in size and essence--of analytical and historical approaches to the genre.
Lamesticumin G, a new α-glucosidase inhibitor from the fruit peels of Lansium parasiticum
Creators: name: Thammatee Potipiranun
name: Wisuttaya Worawalai
name: Preecha Phuwapraisirisan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: A novel onoceranoid triterpene, named lamesticumin G (1) along with four known compounds (2–5) were isolated from the ethyl acetate extract of the fruit peels of Lansium parasiticum. The structure of lamesticumin G (1) was fully characterised using spectroscopic data. Lamesticumin G (1) inhibited α-glucosidase (maltase) with IC50 value of 2.27 mM, while 2–5 showed no inhibition.
Development of Docetaxel Loaded PEG-PLA Nano-Particles Using Surfactant Free Method for Controlled Release Studies
Creators: name: Prajna Mishra
name: R. K. Dey
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Docetaxel (DTX) loaded PEG-PLA is prepared by nano-precipitation method in absence of any surfactants. The average particle size of the copolymer was found to be 101 nm. The drug entrapment efficiency (%) and drug loading (%) of polymer was found to be 9.471 ± 0.047 and 94.71 ± 0.466, respectively. The in vitro drug release characteristics shows controlled release of 98% of docetaxel in 72 h. The MTT assay and apoptosis measured in terms of cleaved PARP and cleaved caspase-3 protein expression shows that the copolymer has better cytotoxicity effect and apoptosis in comparison to free DTX in HeLa cells.
Review of Demetrios Trakatellis, Archbishop of America. Authority and Passion: Christological Aspects of the Gospel According to Mark.
Creators: Gall, William Ephrem
Publisher: name: Columbia University
Year: 2010
Subjects: Religion

description: Our Lord’s image is revealed in the Gospel of Mark with singular clarity and power, according to His Eminence Archbishop Demetrios Trakatellis in his 1987 book Authority and Passion: Christological Aspects of the Gospel According to Mark. This image is held forth as “the irreplaceable criterion of every Christology.”1 This strong statement is supported by a complete exposition of the Gospel of Mark which brings forth key details and much reflection in regard to the two overarching Christological aspects, authority and passion. Authority is the divine Christological aspect, expressions of Christ’s power and glory; passion is the human aspect, the various forms of suffering Christ experienced. These two aspects are woven together in Mark’s narrative to enable the hearer to take both to heart together, avoiding both triumphalism and despair.
Rho-kinase inhibitors from adlay seeds
Creators: name: Yhiya Amen
name: Qinchang Zhu
name: Hai-Bang Tran
name: Afifi, Mohamed S.
name: Halim, Ahmed F.
name: Ashour, Ahmed
name: Fujimoto, Ryoji
name: Goto, Takahiro
name: Kuniyoshi Shimizu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Hematology
subject: 60506 Virology

description: Rho-kinase enzymes are one of the most important targets recently identified in our bodies. Several lines of evidence indicate that these enzymes are involved in many diseases and cellular disorders. ROCK inhibitors may have clinical applications for cancer, hypertension, glaucoma, etc. Our study aims to identify the possible involvement of Rho-kinase inhibition to the multiple biological activities of adlay seeds and provide a rationale for their folkloric medicines. Hence, we evaluated Rho-kinase I and II inhibitory activity of the ethanol extract and 28 compounds derived from the seeds. A molecular docking assay was designed to estimate the binding affinity of the tested compounds with the target enzymes. The results of our study suggest a possible involvement of Rho-kinase inhibition to the multiple biological activities of the seeds. Furthermore, the results obtained with the tested compounds revealed some interesting skeletons as a scaffold for design and development of natural Rho-kinase inhibitors.
Review of Feminist Technology, by Kate Boyer, Linda Layne, and Sharra Vostral
Creators: Natarajan, Vani M.
Publisher: name: Columbia University
Year: 2010
Subjects: Library science

description: The scope of both feminism and technology is vast, and where they meet is no small place. So, the editors focus on just a few medical technologies, with articles on the menstrual suppressing birth control pill, the breast pump, the home pregnancy test, and the tampon. In her introduction, Linda Layne writes, “…clearly technological fixes are not enough. Feminists must also work toward undoing patriarchy in all its forms. This means not only introducing new technologies, but changing technosocial systems…”
Review of Finbarr B. Flood, Objects of Translation: Material Culture and Medieval ‘Hindu– Muslim’ Encounter
Creators: Ahmed Asif, Manan
Publisher: name: Columbia University
Year: 2011
Subjects: History
Middle Ages

description: Finbarr Flood’s Objects of Translation is then a breathtakingly refreshing work of synthesis and analysis. Flood offers us a ‘highly contoured landscape’ of pre-modern (his focus is roughly 800–1250 CE) central-south regions of Asia (from the river Amū Daryā to the Indus valley, from the Iranian region of Khurasan to the Ganges River). In his introduction, Flood makes two central points on the historiography—that the contemporary scholarly accounts of eighth to fourteenth century India are bifurcated, reductive and obscurest, treating this period as little more than background material for the Mughal ecumene; and that contemporary understandings of religious ideations are anachronistically projected onto earlier pasts. To reframe this discourse, Flood focuses on the framework of translation and transculturation where distinct modes of living and knowing are formed as a result of contact with prior forms and are reshaped to create newly intelligible ones. Methodologically, Flood re-opens vistas that modern South Asian studies has diligently avoided: the study of texts as objects, objects as texts and the environments within which both are placed and displaced.
Assessment of secondary school students’ knowledge and attitude towards drug abuse: implications for counselling
Creators: name: YUSUF, FLORENCE ADEOTI
name: OKANLAWON, AYOADE EJIWALE
Publisher: name: Educational Journal of the University of Patras UNESCO Chair
Year: 2019
Subjects: Secondary school students, attitudes, drugs

description: The rate at which adolescents fall victims of drug abuse is high due to their ignorance about the negative consequence of the act. The descriptive study assessed the knowledge and attitude of secondary school students towards drug abuse and its implications for counseling. Random sampling techniques was used in drawn 600 secondary school students from Ilesa Metroplis in Osun State. Four research questions were raised to guide the study. Questionnaire Knowledge and Attitude towards Drug Abuse Questionnaire (KATDAQ) was used in collecting data for the study. Data collected were analyzed using mean scores and mean ranking of items, and t-test. The results of the study reveal that (a) university students were not knowledgeable about drug abuse, (b) they have a positive disposition towards drug abuse, (c) the most common place undergraduates source for information about drug abuse are from friends, neighbours and social networks. It was however, found that there was significant difference in the attitude of male and female students towards drug abuse. Based on the findings of the study, the researcher recommended the establishment of counseling units in the schools, Churches, mosques, other places of worship and the media should work assiduously with a view to curbing drug abuse. The school counsellors should work in collaboration with NDLEA (National Drug Law Enforcement Agency) to be organizing workshop, talks for students on the dangers of drug abuse.
description: Educational Journal of the University of Patras UNESCO Chair, Vol. 6, N. 2 (2019)
Respondents Perception on Appropriate Manifesto Design in General Election
Creators: name: Hua, Ang Kean
name: OWI WEI PING
Publisher: name: figshare
Year: 2017
Subjects: subject: 160609 Political Theory and Political Philosophy
subject: FOS: Political science
subject: 160605 Environmental Politics
subject: 160603 Comparative Government and Politics
subject: 160699 Political Science not elsewhere classified
subject: 160606 Government and Politics of Asia and the Pacific

description: Election through manifesto will ensure winning seat in general election. This research study determinesrespondent’s perception on appropriate manifesto design for the general election. Quantitative approach with questionnaire methods applied into Malacca State in targeting 100 respondents, where questionnaire are divided into two categories namely (1) respondent’s demographic profile, and (2) respondent’s perception on appropriate manifesto designed for general election. Result indicate majority are male with ages from 31 to 40 that working in private sector. Most of respondent studied until secondary level and having monthly income of RM 1501 to RM 2000. Respondents are likely to support registered political parties and vote for same party. At the same time, there are respondents that more preferred towards candidates, especially candidates that have confidence in making decision. Majority respondents receive all contesting candidate’s manifesto and understand every aspect that proposed in manifesto. Fortunately, manifesto becomes positive ‘attraction’ towards respondents in decision making. In other words, although majority respondents are preferred on candidate and party, however, they are more preferred to choose the manifesto that emphasizes on having a safer and a better life not only for themselves, but also for their children in the future generation. Therefore, election manifesto do influencing the respondents in chosen the candidate or party.
Review of Hieromonk Silouan. Wisdom Songs: A Book of Wisdom Chapters in Five Centuries.
Creators: Knitter, Paul
Publisher: name: Columbia University
Year: 2010
Subjects: Religion

description: For anyone not familiar with the ancient patristic genre Kephalaia, hermit Priest-monk Silouan provides an inviting, tantalizing, and, in the end, captivating introduction.
Review of John Chryssavgis. In the Heart of the Desert: The Spirituality of the Desert Fathers and Mothers.
Creators: Petrakis, Vicki
Publisher: name: Columbia University
Year: 2010
Subjects: Religion

description: This study explores the essence of the monastic desert movement from the third century to the end of the fourth century CE by men and women who fled the surrounding cities they lived in, and came into the arid sands of Egypt in order to continue the trajectory of life. The ancient texts that survive, mainly 1,202 Sayings of the Desert Fathers or Apothegmata, which Dr. Chryssavgis explores for the purpose of resurrecting the ancient spirit of the desert within a modern context, reveal that these men and women had been specific about their goal in coming to the desert: “We entreat you, make us truly alive.” In seeking out these “…unconventional persons…[who] sought aggressively to understand the deeper meaning and the fuller measure of human existence…,” the author breathes new life into their Sayings.
Manifesto Based Geographical Applied in General Election: A Review
Creators: name: OWI WEI PING
name: Hua, Ang Kean
Publisher: name: figshare
Year: 2017
Subjects: subject: 160609 Political Theory and Political Philosophy
subject: FOS: Political science
subject: 160605 Environmental Politics
subject: 160603 Comparative Government and Politics
subject: 160699 Political Science not elsewhere classified
subject: 160606 Government and Politics of Asia and the Pacific

description: Manifesto is important tool in ensuring winning the seat in general election, while giving improvement andenhancing the quality of life in the country. Several categories are defined based on geographical perspective inmanifesto, namely safety of our family, a better quality of life, gender equality and empowering youth, generate strongand sustainable growth, balanced development progress for bridging the gaps, increasing access to education andstandard, and people’s threatened crime-disaster hazard. Manifesto successfully implemented will bring better life tocitizen in the country.
Understanding the context of alcohol impaired driving for fatal crash–involved drivers: A descriptive case analysis
Creators: name: Wundersitz, Lisa
name: Raftery, Simon
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: The objective of this study was to understand the social context and circumstances surrounding alcohol-impaired driving prior to fatal crash involvement for drivers with an illegal blood alcohol concentration (BAC ≥ 0.05 g/100 ml or 0.00 g/100 ml for restricted license holders). Methods: Coroners' case reports investigating fatal crashes in South Australia over a 3-year period (2008–2010) were examined. The personal and crash characteristics of drivers with an illegal BAC were compared with those who had a legal BAC. For each driver with an illegal BAC, information was recorded including characteristics of last trip, location and social context of alcohol consumption, quantity and type of alcohol consumed, BAC level, presence of drugs, perceived alcohol intoxication, and alcohol dependence. Official traffic offense records were also obtained. Results: Of the 284 fatal crashes included in the study, 34% (n = 95) involved a driver or rider with an illegal BAC. Prior to the crash, alcohol was most frequently consumed by drivers in rural areas, within private homes, and was part of normal social activities. Drivers recorded a high level of alcohol impairment, with a mean BAC of 0.173 g/100 ml and a level of alcohol dependence that was above the Australian national average (7.4 vs. 3.9%). In addition, 23% of drivers were known to be experiencing psychological stress at the time of the crash. The results also confirm that drink driving recidivism continues to be a significant problem, with 44% of drivers recording at least one prior alcohol driving offense. Conclusions: Alcohol-impaired driving continues to be a leading cause of fatal crashes. The popularity of drinking at home, particularly in rural areas, has implications for police enforcement strategies and suggests that drink driving interventions that focus on community values and looking after friends might be beneficial. Importantly, the study highlights the need for a broader holistic approach to reduce the high levels of alcohol consumption and alcohol dependence underlying drink driving behavior.
Review of Kenton L. Sparks, God's Word in Human Words: An Evangelical Appropriation of Critical Biblical Scholarship
Creators: Vaughan, Matthew
Publisher: name: Columbia University
Year: 2010
Subjects: Religion
Religion--Philosophy
Bible

description: This is a book review of Kenton L. Sparks, "God's Word in Human Words: An Evangelical Appropriation of Critical Biblical Scholarship." Critical biblical scholarship has long seemed only to undermine the authority of the Bible in the minds of both critical and evangelical scholars. This is particularly difficult for evangelicals because it often calls into question such sacred ideas as inerrancy. Many evangelicals simply ignore critical scholarship or deny its conclusions as incorrect. Evangelicalism is ready for another option. Kenton Sparks's new book, God's Word in Human Words, calls for a fresh look at critical scholarship by the evangelical community. Sparks's thesis is that critical scholarship can inform evangelical faith and, in fact, must if the church is to take Scripture seriously on its own terms—acknowledging inaccuracies, tensions, and diversity in the text. He argues that evangelicals must accept three fundamental presuppositions in order to articulate a believing criticism: epistemological humility, a theology of accommodation, and sensitivity to the Bible's theological trajectories.
Education in Malaysia: A Review
Creators: name: OWI WEI PING
name: Hua, Ang Kean
Publisher: name: figshare
Year: 2017
Subjects: subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences
subject: Education
subject: 130102 Early Childhood Education (excl. Maori)
subject: Geography
subject: 130103 Higher Education

description: HOTS can be defined as a concept based on learning Taxonomies Bloom that concerned on analysis, evaluation and synthesis (creation of new knowledge) that required different learning and teaching methods than learning of facts and concept. In other words, HOTS concept concentrate on student understanding in learning process based on their own methods, and able to train students to think creatively, critic and innovative. Due to advantages of HOTS concept, the Malaysian Education System is transforming from ‘chalk and talk’ to ‘students’ centroid’; and yet the concept is continuously changing into Higher Order Thinking Skills (HOTS) that applied into students’ mindset today. Although there is various issues and problems exist among teachers, between-teacher-and-students, and among students on the acceptance of HOTS concept, however, continuous research study is required to increase the effective of implementation on HOTS concept into the mindset which will increase the quality of education system in Malaysia.
Review of Michael F. Palmer. Philosophy of Religion: Classic and Contemporary Readings.
Creators: Trostyanskiy, Sergey
Publisher: name: Columbia University
Year: 2010
Subjects: Religion

description: This anthology of the philosophy of religion represents a successful attempt to introduce the reader to key Western religious thinkers and their heritage. The author’s intention to create a “user-friendly and digestible” book finds its fulfillment in the well-structured and historically contextualized volume which elucidates all essential aspects of philosophy of religion. To the reader’s surprise, this volume, arranged by topic, extends its content beyond the narrow scope of traditional anthologies heavily geared toward a few key themes of philosophy of religion to the exclusion of many other relevant topics. Thus, beyond common themes associated with the attributes of God, the arguments for God’s existence, and the nature of evil, the author introduces philosophical works on miracles, religious language, and the diversity of world religions, among others. The most distinctive features of this book are its carefully crafted introductions to each chapter’s problems; biographical and philosophical summaries of each thinker; and the list of primary and secondary sources that will allow the reader to pursue the further studies on the subject.
Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination
Creators: name: Wang, Hongyu
name: Xue, Quanlin
name: Zhang, Haocheng
name: Yuan, Guanmin
name: Wang, Xun
name: Sheng, Kai
name: Li, Chen
name: Cai, Jianpeng
name: Sun, Yuhan
name: Zhao, Jingjing
name: Lu, Jiahuan
name: Fang, Shuyu
name: Yang, Yongfeng
name: Zhang, Yeting
name: Huang, Ying
name: Wang, Jiancui
name: Xu, Jonathan H
name: Jiang, Melissa X
name: Wang, Xinyu
name: Shen, Lei
name: Liu, Yuanyuan
name: Liu, Qihui
name: Zhang, Qiran
name: Wang, Sen
name: Wang, Pengfei
name: Qiu, Chao
name: Ai, Jingwen
name: Zhang, Wenhong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Background: Omicron had swept the mainland China between December 2022 and January 2023, while SARS-CoV-2 still continued to evolve. To fully prepare for the next wave, it’s urgent to evaluate the humoral immune response post BA.5/BF.7 breakthrough infection against predominant sublineages among existing vaccination strategies and the elders. Method: This study enrolled a longitudinal young-adult cohort from 2/3-dose vaccination to 1 month after breakthrough infection, and an elder cohort at 1 month after breakthrough infection. Seral samples were collected and tested for humoral immune response to SARS-CoV-2 subvariants including WT, BA.2, BA.5, BF.7, BQ.1.1, CH.1.1, XBB.1.5. Results: BA.5/BF.7 breakthrough infection induced higher neutralization activity than solely vaccination in all SARS-CoV-2 strains, while the latest Omicron subvariants, BQ.1.1, CH.1.1, XBB.1.5, exhibited the strongest neutralization evasion ability. There was a negative correlation between age and humoral immune response in WT, BA.5, BQ.1.1, and XBB.1.5. Compared to non-vaccination groups, breakthrough infection in two-dose vaccination groups had significantly higher neutralizing antibody against WT, BA.2, BA.5, BF.7 but not to BQ.1.1, CH.1.1, XBB.1.5., while booster dose against the prototype prior-breakthrough would not further significantly enhance individual’s humoral responses against the latest Omicron subvariants. Conclusions: Newer variants manifest increasing immune evasion from neutralization and repeated prototype-based booster vaccines may not further enhance neutralizing antibody against emerging new variants. Older adults have lower levels of neutralizing antibody. Future vaccination strategies should aim to enhance effective neutralization to contemporary variants.