Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis
Creators: name: Haufe, Sven
name: Hupa-Breier, Katharina L.
name: Bayerle, Pauline
name: Boeck, Hedwig T.
name: Rolff, Simone
name: Sundermeier, Thorben
name: Kerling, Arno
name: Eigendorf, Julian
name: Kück, Momme
name: Hanke, Alexander A.
name: Ensslen, Ralf
name: Nachbar, Lars
name: Lauenstein, Dirk
name: Böthig, Dietmar
name: Hilfiker-Kleiner, Denise
name: Stiesch, Meike
name: Terkamp, Christoph
name: Wedemeyer, Heiner
name: Haverich, Axel
name: Tegtbur, Uwe
Publisher: name: London : Nature Publ. Group
Year: 2021
Subjects: subject: Adult
subject: Exercise
subject: Exercise Therapy
subject: Female
subject: Germany
subject: Humans
subject: Life Style
subject: Linear Models
subject: Liver
subject: Liver Cirrhosis
subject: Liver Function Tests
subject: Male
subject: Metabolic Syndrome
subject: Middle Aged
subject: Obesity
subject: Prospective Studies
subject: Telemetry
subject: Wearable Electronic Devices
subject: alanine aminotransferase
subject: alkaline phosphatase
subject: aminotransferase
subject: anticoagulant agent
subject: antidiabetic agent
subject: antihypertensive agent
subject: antilipemic agent
subject: aspartate aminotransferase
subject: creatinine
subject: gamma glutamyltransferase
subject: hemoglobin A1c
subject: low density lipoprotein cholesterol
subject: urea
subject: adult
subject: alcohol consumption
subject: anxiety
subject: aspartate aminotransferase to platelet ratio index
subject: body composition
subject: carbohydrate intake
subject: cholesterol blood level
subject: cohort analysis
subject: controlled study
subject: depression
subject: exercise
subject: female
subject: Freiburger Physical Activity Questionnaire
subject: general health status assessment
subject: hepatitis
subject: human
subject: hypertransaminasemia
subject: liver fibrosis
subject: liver injury
subject: major clinical study
subject: male
subject: metabolic fatty liver
subject: metabolic syndrome X
subject: middle aged
subject: obesity
subject: platelet count
subject: prospective study
subject: protein intake
subject: randomized controlled trial (topic)
subject: Short Form 36
subject: telemonitoring
subject: electronic device
subject: kinesiotherapy
subject: lifestyle
subject: liver
subject: liver cirrhosis
subject: liver function test
subject: pathology
subject: pathophysiology
subject: procedures
subject: randomized controlled trial
subject: statistical model
subject: telemetry
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: INTRODUCTION:Metabolic syndrome (MetS) is a major health problem worldwide and the main risk factor for metabolic-associated fatty liver disease (MAFLD). Established treatment options are lifestyle interventions facilitating dietary change and increased physical activity. Here, we tested the effect of a telemonitoring-supported intervention on liver parameter of inflammation and fibrosis in individuals with MetS.METHODS:This was a prospective, randomized, parallel-group, and assessor-blind study performed in workers of the main Volkswagen factory (Wolfsburg, Germany). Volunteers with diagnosed MetS were randomly assigned (1:1) to a 6-month lifestyle intervention focusing on supervised, activity-tracker-guided exercise or to a waiting-list control group. This secondary analysis assessed the effect of the intervention on liver enzymes and MAFLD-related parameters.RESULTS:We screened 543 individuals between October 10, 2017, and February 27, 2018, of whom 314 were randomly assigned to the intervention group (n = 160) or control group (n = 154). Liver transaminases, alkaline phosphatase, and gamma-glutamyl transferase significantly decreased after 6 months in the intervention group compared with the CG. Furthermore, an aspartate aminotransferase-to-platelet ratio index score as a marker for liver fibrosis significantly decreased in the intervention group. These improvements were associated with changes in obesity and exercise capacity.DISCUSSION:A 6-month lifestyle intervention based on exercise training with individualized telemonitoring-based supervision led to improvements of liver inflammation and fibrosis in employees with MetS. Therefore, this intervention shows therapeutic potential for individuals at high risk of MAFLD (ClinicalTrials.gov Identifier: NCT03293264).