cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Randomized Trial of Real-Time Geriatric Assessment Reporting in Nonelectively Hospitalized Older Adults with Cancer
Creators: name: Deal, A.M.
name: Markowski, N.
name: Kirk, S.
name: Busby-Whitehead, J.
name: Jolly, T.A.
name: Choi, S.K.
name: Mariano, C.
name: Perlmutt, M.S.
name: Jones, F.
name: Nyrop, K.A.
name: Muss, H.
Publisher: name: Wiley-Blackwell
Year: 2020

description: Background: Hospitalized older adults have significant geriatric deficits that may lead to poor outcomes. We conducted a randomized trial to investigate the effectiveness of providing clinicians with a real-time geriatric assessment (GA) report in nonelectively hospitalized older patients with cancer. Subjects, Materials, and Methods: We developed a web-based software platform for administering a modified GA (Cancer 2005; 104:1998–2005) to older (>70 years) nonelectively hospitalized patients with pathologically confirmed malignancy. Patients were randomized to have their GA report provided to their treating clinicians (Intervention arm) or not provided (Control arm). Results: Our study included 135 patients, median age 76 years, 52% female, 75% white, 21% black, 79% greater than high school education, 59% married, and 17% living alone. All patients had at least one GA-identified deficit, including physical function deficits (90%), cognitive impairment (22%), >5 comorbidities (28%), polypharmacy (>9 medications; 38%), weight loss ≥10% in the past 6 months (40%), anxiety (32%), or depression (30%). There was no difference between the Intervention (6%) and Control arms (9%) in the proportion of patients who were referred by their clinical team for an intervention to address a deficit (p =.53). Conclusion: Many older nonelectively hospitalized patients with cancer have geriatric deficits that are amenable to evidence-based interventions. Real-time GA reports provided to the care team prior to discharge did not influence provider referral for such interventions. There is a need for systems-level interventions to address deficits in this vulnerable patient population. Implications for Practice: Geriatric deficits are common in hospitalized older adults with cancer and lead to poor outcomes. Addressing modifiable deficits represents an appealing way to improve outcomes. Widespread geriatrician consultation is impractical owing to resource and personnel constraints. This work tested whether prompt delivery of a mostly self-administered, web-based geriatric assessment report to clinicians improved referral rates for evidence-informed interventions. It confirmed frequent geriatric deficits and high readmission rates in this population but found that real-time geriatric assessment reporting did not influence provider referral for evidence-informed interventions on geriatric assessment identified deficits. These findings highlight the need for systems-level intervention to improve outcomes in this vulnerable patient population.
Detailed microkinetic analysis of reactions in the C/H/O/N system over platinum
Creators: name: Tsopelakou, Aliki Marina
Publisher: name: Imperial College London
Year: 2020

description: The present PhD thesis considers an alternative theoretical framework based on Variational Transition State Theory (VTST) for estimating Arrhenius parameters for adsorption reactions. The estimation of rate data suitable for microkinetic analysis of reaction pathways in heterogeneous catalytic systems typically requires sticking coefficients. The use of VTST enables the construction of chemical mechanisms without the dependency on experimental data for sticking coefficients, for the final determination of the rate parameters. The energetics of the surface reactions are derived using the Unity Bond Index-Quadratic Exponential Potential (UBI-QEP) method. A comprehensive chemical mechanism is developed for the description of the surface reactions associated with the catalytic removal of the three principal oxides of nitrogen (NO, NO2 and N2O) from automotive exhaust gases through the use of supported platinum catalysts. The reference five-step Pt catalytic mechanism [1] for NO removal has been updated to 21 reversible reaction steps featuring all principal oxides of nitrogen. Gas phase reactions are considered, via a comprehensive C/H/O/N mechanism that includes ammonia. The NOx reduction mechanism was applied under nearly stoichiometric conditions, various metal loadings and coat amounts. A rigorous comparison with experimental data [2], obtained by Toyota Motor Europe, for nine different Test Cases was performed along with the analysis of modifications to the energetics and rate parameters. The outcomes obtained for CO, NO and C3H6 conversion against temperature present a promising agreement with the experimental data [2]. The same framework, with the absence of the nitrogen and propene containing catalytic chemistry, is implemented to study the ethane auto-thermal catalytic cracking in a quartz lined tubular reactor. The validation of the mechanism was carried out via experimental measurements provided by BP Chemicals [3]. The absence and presence of CO in the feed stream were studied to further explore the catalytic activity of the chemical system. The work provides a framework for the development of heterogeneous reaction mechanisms, without the reliance on experimental sticking coefficients, focusing on the reduction of NOx emissions from the automotive exhaust gases. The proposed method can be further augmented and used for the generation of novel heterogeneous reaction mechanisms.
(3510) Ada Plumb
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Lattice QCD input for axion cosmology
Creators: name: Berkowitz, Evan
name: Buchoff, Michael I.
name: Rinaldi, Enrico
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: One intriguing BSM particle is the QCD axion, which could simultaneously provide a solution to the Strong CP problem and account for some, if not all, of the dark matter density in the universe. This particle is a pNGB of the conjectured Peccei-Quinn (PQ) symmetry of the Standard Model. Its mass and interactions are suppressed by a heavy symmetry breaking scale, $f_a$, whose value is roughly greater than $10^{9}$ GeV (or, conversely, the axion mass, $m_a$, is roughly less than $10^4\ μ\text{eV}$). The density of axions in the universe, which cannot exceed the relic dark matter density and is a quantity of great interest in axion experiments like ADMX, is a result of the early-universe interplay between cosmological evolution and the axion mass as a function of temperature. The latter quantity is proportional to the second derivative of the QCD free energy with respect to the CP-violating phase, $θ$. However, this quantity is generically non-perturbative and previous calculations have only employed instanton models at the high temperatures of interest (roughly 1 GeV). In this and future works, we aim to calculate the temperature-dependent axion mass at small $θ$ from first-principle lattice calculations, with controlled statistical and systematic errors. Once calculated, this temperature-dependent axion mass is input for the classical evolution equations of the axion density of the universe. Due to a variety of lattice systematic effects at the very high temperatures required, we perform a calculation of the leading small-$θ$ cumulant of the theta vacua on large volume lattices for SU(3) Yang-Mills with high statistics as a first proof of concept, before attempting a full QCD calculation in the future. From these pure glue results, the misalignment mechanism yields the axion mass bound $m_a \geq (14.6\pm0.1) \ μ\text{eV}$ when PQ-breaking occurs after inflation.
description: 26 pages, 9 figures
Various morphologies observed in the power spectra of suppressed-dipole mode red giants
Creators: name: Coppée, Quentin
name: Müller, Jonas
name: Bazot, Michaël
name: Hekker, Saskia
Publisher: name: Zenodo
Year: 2024

description: The Kepler mission provided light curves for over 16,000 red giants, of which a small fraction show reduced power in the dipole modes. We analysed both the radial and dipole modes in the power spectra of almost 600 red giants with low dipole-mode amplitudes. We found that the radial modes are unaffected by the suppression, suggesting that the suppression is mostly active in the central regions of the star. Moreover, we confirm that the majority of these stars still have observable mixed dipole modes, i.e., no complete suppression of the contribution from the inner regions to the dipole modes. This is in contradiction with the assumption of certain suppression mechanisms proposed in the literature. Finally, we also find different types of frequency-dependent suppression in the power spectra related to the stellar evolution. These new suppression types can lead to new constraints on and insights into the suppression mechanism(s) at play.
Is “Geriatric” Assessment Just for Older Patients?
Creators: name: Wood, W.A.
name: Choi, S.K.
name: Aleixo, G.F.P.
name: Tan, A.J.
name: Deal, A.M.
name: Nyrop, K.A.
name: Jolly, T.A.
name: Muss, H.B.
Publisher: name: Wiley-Blackwell
Year: 2020

description: Geriatric assessment (GA) is used in oncology to identify deficits in older patients with cancer that may affect treatment choice. We examine GA in 550 patients with early breast cancer, including both younger (<65 years) and older women (aged 65 years or older), to assess the potential value of this tool in younger, presumed “healthier” patients. Although older women have more GA-identified deficits overall, younger patients are more anxious. Suboptimal physical function was problematic across the age spectrum. GA domains can identify major deficits in younger patients beyond those likely to be uncovered in routine investigation.
Patient-reported and clinician-reported chemotherapy-induced peripheral neuropathy in patients with early breast cancer: Current clinical practice
Creators: name: Basch, E.
name: Choi, S.K.
name: Reeder-Hayes, K.E.
name: Deal, A.M.
name: Lee, J.T.
name: Jolly, T.A.
name: Reinbolt, R.E.
name: Speca, J.C.
name: Shachar, S.S,
name: Reeve, B.B.
name: Wood, W.A.
name: Kimmick, G.G.
name: Anders, C.K.
name: Karuturi, M.S.
name: Muss, H.B.
name: Nyrop, K.A.
name: Dees, E.C.
name: Carey, L.A.
Publisher: name: John Wiley and Sons Inc
Year: 2019

description: Background: In the current study, the authors investigated the incidence of moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) for chemotherapy regimens commonly used in current clinical practice for the treatment of patients with early breast cancer. Patient-reported and clinician-assessed CIPN severity scores were compared, and risk factors for CIPN severity were identified. Methods: Patients completed a Patient-Reported Symptom Monitoring form and oncologists completed a Common Terminology Criteria for Adverse Events form. CIPN reports were collected prospectively during regularly scheduled infusion visits throughout the duration of chemotherapy. Results: The sample included 184 women with a mean age of 55 years; approximately 73% were white. The 4 chemotherapy regimens used were doxorubicin and cyclophosphamide plus paclitaxel (60 patients); docetaxel and cyclophosphamide (50 patients); docetaxel, carboplatin, and anti–human epidermal growth factor receptor 2 (HER2) (24 patients); and doxorubicin and cyclophosphamide plus paclitaxel and carboplatin (18 patients). All patients treated with doxorubicin and cyclophosphamide plus paclitaxel and doxorubicin and cyclophosphamide plus paclitaxel and carboplatin received paclitaxel; all patients treated with docetaxel and cyclophosphamide and docetaxel, carboplatin, and anti-HER2 received docetaxel. The chemotherapy dose was reduced in 52 patients (28%); in 15 patients (29%), this reduction was due to CIPN. Chemotherapy was discontinued in 26 patients (14%), 8 because of CIPN. Agreement between patient-reported and clinician-assessed CIPN severity scores was minimal (weighted Cohen kappa, P =.34). Patient-reported moderate to severe CIPN was higher for paclitaxel (50%) compared with docetaxel (17.7%) (P <.001). Pretreatment arthritis and/or rheumatism (relative risk [RR], 1.58; 95% CI, 1.06-2.35 [P =.023]) and regimens containing paclitaxel (RR, 2.88; 95% CI, 1.72-4.83 [P <.0001]) were associated with higher CIPN severity. Being married (RR, 0.57; 95% CI, 0.37-0.887 [P =.01]) was found to be associated with lower CIPN severity. Conclusions: The discrepancy between patient-reported and clinician-assessed CIPN underscores the need for both patient and clinician perspectives regarding this common, dose-limiting, and potentially disabling side effect of chemotherapy.
Quantum-enhanced gyroscopy with rotating anisotropic Bose--Einstein condensates
Creators: name: Rico-Gutierrez, L. M.
name: Spiller, T. P.
name: Dunningham, J. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: High-precision gyroscopes are a key component of inertial navigation systems. By considering matter wave gyroscopes that make use of entanglement it should be possible to gain some advantages in terms of sensitivity, size, and resources used over unentangled optical systems. In this paper we consider the details of such a quantum-enhanced atom interferometry scheme based on atoms trapped in a carefully-chosen rotating trap. We consider all the steps: entanglement generation, phase imprinting, and read-out of the signal and show that quantum enhancement should be possible in principle. While the improvement in performance over equivalent unentangled schemes is small, our feasibility study opens the door to further developments and improvements.
description: 13 pages, 6 figures
(3512) Alice Desborough
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Forward Modelling of Standing Slow Modes in Flaring Coronal Loops
Creators: name: Yuan, D.
name: Van Doorsselaere, T.
name: Banerjee, D.
name: Antolin, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Standing slow mode waves in hot flaring loops are exclusively observed in spectrometers and are used to diagnose the magnetic field strength and temperature of the loop structure. Due to the lack of spatial information, the longitudinal mode cannot be effectively identified. In this study, we simulate standing slow mode waves in flaring loops and compare the synthesized line emission properties with SUMER spectrographic and SDO/AIA imaging observations. We find that the emission intensity and line width oscillations are a quarter period out of phase with Doppler shift velocity both in time and spatial domain, which can be used to identify a standing slow mode wave from spectroscopic observations. However, the longitudinal overtones could be only measured with the assistance of imagers. We find emission intensity asymmetry in the positive and negative modulations, this is because the contribution function pertaining to the atomic emission process responds differently to positive and negative temperature variations. One may detect \textbf{half} periodicity close to the loop apex, where emission intensity modulation is relatively small. The line-of-sight projection affects the observation of Doppler shift significantly. A more accurate estimate of the amplitude of velocity perturbation is obtained by de-projecting the Doppler shift by a factor of $1-2θ/π$ rather than the traditionally used $\cosθ$. \textbf{If a loop is heated to the hotter wing, the intensity modulation could be overwhelmed by background emission, while the Doppler shift velocity could still be detected to a certain extent.
description: 18 pages, 10 figures, Astrophysics Journal
Holographic dark energy models with Interactions and entropy corrections for different cutoffs in the Brans-Dicke cosmology
Creators: name: Darabi, F.
name: Felegary, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In the framework of Brans-Dicke cosmology, we have studied the interacting power-law and logarithmic entropy-corrected holographic dark energy models with different cut-offs. The Brans-Dicke parameter is investigated versus the conditions for the acceleration and phantom phases to show that which entropy corrected model can exhibit acceleration with or without the phantom phase at early and present time universes. Moreover, the classical stability or instability of the interacting power-law and logarithmic entropy-corrected holographic dark energy models with different cut-offs is determined at early and present time
description: 14 pages, 6 tables
Measuring and understanding adherence in a home-based exercise intervention during chemotherapy for early breast cancer
Creators: name: Nyrop, K.A.
name: Wagoner, C.W.
name: Muss, H.B.
name: Carey, L.A.
name: Dees, E.C.
name: Reeder-Hayes, K.E.
name: Anders, C.
name: Deal, A.M.
name: Jolly, T.A.
name: Choi, S.K.
name: Wood, A.
name: Lee, J.T.
Publisher: name: Springer New York LLC
Year: 2018

description: Purpose: Ensuring and measuring adherence to prescribed exercise regimens are fundamental challenges in intervention studies to promote exercise in adults with cancer. This study reports exercise adherence in women who were asked to walk 150 min/week throughout chemotherapy treatment for early breast cancer. Participants were asked to wear a FitbitTM throughout their waking hours, and Fitbit steps were uploaded directly into study computers. Methods: Descriptive statistics are reported, and both unadjusted and multivariable linear regression models were used to assess associations between participant characteristics, breast cancer diagnosis, treatment, chemotherapy toxicities, and patient-reported symptoms with average Fitbit steps/week. Results: Of 127 women consented to the study, 100 had analyzable Fitbit data (79%); mean age was 48 and 31% were non-white. Mean walking steps were 3956 per day. Nineteen percent were fully adherent with the target of 6686 steps/day and an additional 24% were moderately adherent. In unadjusted analysis, baseline variables associated with fewer Fitbit steps were: non-white race (p = 0.012), high school education or less (p = 0.0005), higher body mass index (p = 0.0024), and never/almost never drinking alcohol (p = 0.0048). Physical activity variables associated with greater Fitbit steps were: pre-chemotherapy history of vigorous physical activity (p = 0.0091) and higher self-reported walking minutes/week (p < 0.001), and higher outcome expectations from exercise (p = 0.014). Higher baseline anxiety (p = 0.03) and higher number of chemotherapy-related symptoms rates “severe/very severe” (p = 0.012) were associated with fewer steps. In multivariable analysis, white race was associated with 12,146 greater Fitbit steps per week (p = 0.004), as was self-reported walking minutes prior to start of chemotherapy (p < 0.0001). Conclusions: Inexpensive commercial-grade activity trackers, with data uploaded directly into research computers, enable objective monitoring of home-based exercise interventions in adults diagnosed with cancer. Analysis of the association of walking steps with participant characteristics at baseline and toxicities during chemotherapy can identify reasons for low/non-adherence with prescribed exercise regimens.
(3507) Robert Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Adjuvant treatment for older women with invasive breast cancer
Creators: name: Nyrop, K.A.
name: Williams, G.R.
name: Jolly, T.A.
name: Muss, H.B.
name: Bushan, S.
name: Jones, E.L.
name: Pergolotti, M.
Publisher: name: Future Medicine Ltd.
Year: 2016

description: Older women experience a large share of breast cancer incidence and death. With the projected rise in the number of older cancer patients, adjuvant chemo-, radiation and endocrine therapy management will become a key component of breast cancer treatment in older women. Many factors influence adjuvant treatment decisions including patient preferences, life expectancy and tumor biology. Geriatric assessment predicts important outcomes, identifies key deficits, and can aid in the decision making process. This review utilizes clinical vignettes to illustrate core principles in adjuvant management of breast cancer in older women and suggests an approach incorporating life expectancy and geriatric assessment.
Additional file 1 of Application of the Khorana score for cancer-associated thrombosis prediction in patients of East Asian ethnicity undergoing ambulatory chemotherapy
Creators: name: Ha, Hyerim
name: Ko, Yeh-Hee
name: Kim, Kwangsoo
name: Hong, Junshik
name: Lee, Gyeong-Won
name: Jeong, Seong Hyun
name: Bang, Soo-Mee
name: Yoon, Sung-Soo
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 1
Genome analysis of coxsackievirus B1 isolates during the consecutive alternating administration course of triple antiviral combination in newborn mice
Creators: name: Stoyanova, A.
name: Joffret, M.-L.
name: Grozdanov, P.
name: Polston, P.
name: Achouri, E.
name: Nikolova, I.
name: Delpeyroux, F.
name: Galabov, A.S.
Publisher: name: SAGE Publications Inc.
Year: 2020

description: Background: We developed a new approach for the treatment of enterovirus infections, the consecutive alternating administration (CAA) of a combination of enterovirus inhibitors. On the model of coxsackievirus B1 (CVB1) in mice, two phenomena were observed: absence of drug resistance and increased susceptibility to the antivirals. This study aims to clarify the genetic basis of these phenomena. Methods: Brain samples from CVB1-infected mice subjected to a CAA course with the combination pleconaril/MDL-860/oxoglaucine were used for viral RNA extraction and next generation sequencing. In parallel, samples from monotherapeutic courses of the three substances included in the combination were studied. Whole genome sequence analysis was carried out on all samples. Results: Samples of pleconaril monotherapy showed mutations in 5′untranslated region, VP3, 2C, 3C and 2A regions of viral RNA, translated in amino acid substitution of the 2A protein. The MDL-860 course induced changes in CVB1 RNA in the VP3 and 2C regions. The oxoglaucine monotherapy samples showed RNA mutation and amino acid substitution in the VP1 region and nucleotide substitution in the 3D region. In the specimens taken from mice subjected to the CAA course with pleconaril/MDL-860/oxoglaucine, the following RNA mutations were established: 5′ untranslated region, 2A, and 2B, and amino acids substitutions in VP3 and 2A, which differ from those mentioned above. These changes could be the reason for the prevention of drug resistance development and also to be considered as the basis for the phenomenon of increased drug susceptibility. Conclusions: The results reveal that the high anti-enteroviral efficacy of the CAA course is substantiated by the appearance of specific changes in the viral genome.
Whole genome sequencing of Enterovirus species C isolates by high-throughput sequencing: Development of generic primers
Creators: name: Sadeuh-Mba, S.A.
name: Blondel, B.
name: Joffret, M.-L.
name: Razafindratsimandresy, R.
name: Bessaud, M.
name: Volle, R.
name: Njouom, R.
name: Rakoto-Andrianarivelo, M.
name: Polston, P.
name: Delpeyroux, F.
Publisher: name: Frontiers Media S.A.
Year: 2016

description: Enteroviruses are among the most common viruses infecting humans and can cause diverse clinical syndromes ranging from minor febrile illness to severe and potentially fatal diseases. Enterovirus species C (EV-C) consists of more than 20 types, among which the three serotypes of polioviruses, the etiological agents of poliomyelitis, are included. Biodiversity and evolution of EV-C genomes are shaped by frequent recombination events. Therefore, identification and characterization of circulating EV-C strains require the sequencing of different genomic regions. A simple method was developed to quickly sequence the entire genome of EV-C isolates. Four overlapping fragments were produced separately by RT-PCR performed with generic primers. The four amplicons were then pooled and purified prior to being sequenced by a high-throughput technique. The method was assessed on a panel of EV-Cs belonging to a wide-range of types. It can be used to determine full-length genome sequences through de novo assembly of thousands of reads. It was also able to discriminate reads from closely related viruses in mixtures. By decreasing the workload compared to classical Sanger-based techniques, this method will serve as a precious tool for sequencing large panels of EV-Cs isolated in cell cultures during environmental surveillance or from patients, including vaccine-derived polioviruses.
[Pdf/ePub/Mobi] TE ENCONTRARE EN EL SILENCIO - LENA BLAU descargar ebook gratis
Creators: name: Kruse
Publisher: name: Zenodo
Year: 2024

description: TE ENCONTRARE EN EL SILENCIO de LENA BLAU

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TE ENCONTRARE EN EL SILENCIO

LENA BLAU

Número de páginas: 400

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788419501271

Editorial: MONTENA

Año de edición: 2023

 

 

 

 

 

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HAY PREGUNTAS QUE NO CONOCES. Y RESPUESTAS QUE LO CAMBIAN TODO PARA SIEMPRE. La novela más romántica de Lena Blau. Amy es como una pieza de puzle perdida, de contornos suaves y redondos, que nunca ha encajado en el molde cuadriculado en el que sus padres la obligaron a entrar. Alan está lleno de aristas agudas y afi ladas, y solo es capaz de ver la vida en blanco y negro.Ella deja Nueva York para buscar la luz y el color que le faltan. Él se va de Londres para cumplir una promesa antes de rendirse definitivamente a la oscuridad. Cuando se conocen en una bahía de playas infi nitas al sur de San Francisco y emprenden un viaje inesperado por la costa de California, descubren que son dos piezas muy distintas que se complementan, por mucho que intenten evitarlo.Y es que, a veces, basta con una cámara de fotos para capturar la verdad que el silencio se empeña en ocultar.LAS LECTORAS HAN DICHO: “Nunca el silencio me había atrapado y erizado la piel como con este libro. Secretos, reencuentros, lugares especiales y mucho amor dentro de estas páginas”. Estefanía Hergueta, @EL_PARAISO_EN_LETRAS “Una historia llena de interrogantes que te tendrá enganchada a sus páginas hasta el
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine
Creators: name: Herrmann, M.
name: Ebenig, A.
name: Schnierle, B.S.
name: Horner, C.
name: Scholz, T.
name: Schurmann, C.
name: Dinnon III, K.H.
name: Muraleedharan, S.
name: Baric, R.S.
name: Auste, A.
name: Muhlebach, M.D.
Publisher: name: National Academy of Sciences
Year: 2020

description: The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has spread worldwide, with millions of cases and more than 1 million deaths to date. The gravity of the situation mandates accelerated efforts to identify safe and effective vaccines. Here, we generated measles virus (MeV)-based vaccine candidates expressing the SARS-CoV-2 spike glycoprotein (S). Insertion of the full-length S protein gene in two different MeV genomic positions resulted in modulated S protein expression. The variant with lower S protein expression levels was genetically stable and induced high levels of effective Th1- biased antibody and T cell responses in mice after two immunizations. In addition to neutralizing IgG antibody responses in a protective range, multifunctional CD8+and CD4+T cell responses with S protein-specific killing activity were detected. Upon challenge using a mouse-adapted SARS-CoV-2, virus loads in vaccinated mice were significantly lower, while vaccinated Syrian hamsters revealed protection in a harsh challenge setup using an early-passage human patient isolate. These results are highly encouraging and support further development of MeV-based COVID-19 vaccines.
(3504) Ada Fisher
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
UN NUEVO ENGAÑO leer epub gratis
Creators: name: Galloway
Publisher: name: Zenodo
Year: 2024

description: UN NUEVO ENGAÑO de JEN DELUCA

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UN NUEVO ENGAÑO

JEN DELUCA

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788419131324

Editorial: TITANIA

Año de edición: 2024

 

 

 

 

 

Descarga de libros de audio de texto UN NUEVO ENGAÑO 9788419131324 de JEN DELUCA

 

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En la feria medieval de Willow Creekáencontrarás de todo: guirnaldas deáflores, faldas escocesas, corses, luchasáde espadas... Y mucho amor.April Parker es madre soltera y ha vivido en Willow Creek duranteádoce años. Ahora está a punto de quedarse con el nido vacío, asíáque decide mudarse de su pequeño y pintoresco pueblo. Y, poráello, le pide ayuda a su amigo Mitch con algunas mejoras paraádejar su casa lista para la venta.Mitch Malone es conocido por ser el alma de todas las fiestas, peroásobre todo por el atuendo que usa en la feria medieval: una faldaáescocesa (y poco más) que resalta sus músculos a la perfección. Si bienáacepta ayudar a April, tambien necesita que ella le devuelva el favor:átendrá que fingir ser su novia en la próxima cena familiar para evitarálos sermones sobre sentar cabeza. April acepta a regañadientes, peroácuando la cena se convierte en un viaje de fin de semana, resulta difícilásaber que parte es real y cuál puro teatro. Pero la reunión familiar llegaáa su fin, y, con ella, su relación fingida.Cuando en verano la feria regresa a Willow Creek y la familia de Mitcháaparece por sorpresa, April debe fingir una vez más. pero ahoraánada parece tan falso. Y aunque ella se empeñe en negar su evidenteáconexión, ¿podrá abrir su
Warm intermediate inflation in the Randall-Sundrum II model in the light of Planck 2015 and BICEP2 results: A general dissipative coefficient
Creators: name: Herrera, Ramón
name: Videla, Nelson
name: Olivares, Marco
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A warm inflationary Universe in the Randall-Sundrum II model during intermediate inflation is studied. For this purpose, we consider a general form for the dissipative coefficient $Γ(T,ϕ)=C_ϕ\,\frac{T^{m}}{ϕ^{m-1}}$, and also analyze this inflationary model in the weak and strong dissipative regimes. We study the evolution of the Universe under the slow-roll approximation and find solutions to the full effective Friedmann equation in the brane-world framework. In order to constrain the parameters in our model, we consider the recent data from the BICEP2-Planck 2015 data together with the necessary condition for warm inflation $T>H$, and also the condition from the weak (or strong) dissipative regime.
description: 26 pages, 3 figures, accepted for publication in the European Physical Journal C
title: Geometry- and Accuracy-Preserving Random Forest Proximities with Applications
Creators: name: Rhodes, Jake S.
Publisher: name: Utah State University
Year: 2022

description: Many machine learning algorithms use calculated distances or similarities between data observations to make predictions, cluster similar data, visualize patterns, or generally explore the data. Most distances or similarity measures do not incorporate known data labels and are thus considered unsupervised. Supervised methods for measuring distance exist which incorporate data labels and thereby exaggerate separation between data points of different classes. This approach tends to distort the natural structure of the data. Instead of following similar approaches, we leverage a popular algorithm used for making data-driven predictions, known as random forests, to naturally incorporate data labels into similarity measures known as random forest proximities. In this dissertation, we explore previously defined random forest proximities and demonstrate their weaknesses in popular proximity-based applications. Additionally, we develop a new proximity definition that can be used to recreate the random forest’s predictions. We call these random forest-geometry-and accuracy-Preserving proximities or RF-GAP. We show by proof and empirical demonstration can be used to perfectly reconstruct the random forest’s predictions and, as a result, we argue that RF-GAP proximities provide a truer representation of the random forest’s learning when used in proximity-based applications. We provide evidence to suggest that RF-GAP proximities improve applications including imputing missing data, detecting outliers, and visualizing the data. We also introduce a new random forest proximity-based technique that can be used to generate 2- or 3-dimensional data representations which can be used as a tool to visually explore the data. We show that this method does well at portraying the relationship between data variables and the data labels. We show quantitatively and qualitatively that this method surpasses other existing methods for this task.
(3505) Victoria Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Ultrafast water permeation through nanochannels with a densely fluorous interior surface
Creators: name: Itoh, Yoshimitsu
name: Chen, Shuo
name: Hirahara, Ryota
name: Konda, Takeshi
name: Aoki, Tsubasa
name: Ueda, Takumi
name: Shimada, Ichio
name: Cannon, James J.
name: Shao, Cheng
name: Shiomi, Junichiro
name: Tabata, Kazuhito V.
name: Noji, Hiroyuki
name: Sato, Kohei
name: Aida, Takuzo
Publisher: name: Zenodo
Year: 2022

description: Ultrafast water permeation in aquaporins is promoted by their hydrophobic interior surface. Polytetrafluoroethylene has a dense fluorine surface, leading to its strong water repellence. We report a series of fluorous oligoamide nanorings with interior diameters ranging from 0.9 to 1.9 nanometers. These nanorings undergo supramolecular polymerization in phospholipid bilayer membranes to form fluorous nanochannels, the interior walls of which are densely covered with fluorine atoms. The nanochannel with the smallest diameter exhibits a water permeation flux that is two orders of magnitude greater than those of aquaporins and carbon nanotubes. The proposed nanochannel exhibits negligible chloride ion (Cl – ) permeability caused by a powerful electrostatic barrier provided by the electrostatically negative fluorous interior surface. Thus, this nanochannel is expected to show nearly perfect salt reflectance for desalination.
description: For the detailed methods to calculate the water permeability, please refer to the Supplemental Information (https://doi.org/10.5281/zenodo.7037980).Funding provided by: Japan Society for the Promotion of Science
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001691
Award Number: 18H05260Funding provided by: Japan Science and Technology Agency
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002241
Award Number: JPMJPR21Q1Funding provided by: Japan Society for the Promotion of Science
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001691
Award Number: 21H01903
PDF [Download] Chica conoce chica / She Gets the Girl by Rachael Lippincott, ALYSON DERRICK
Creators: name: Lake
Publisher: name: Zenodo
Year: 2024

description: Chica conoce chica / She Gets the Girl by Rachael Lippincott, ALYSON DERRICK

 

 

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Chica conoce chica / She Gets the Girl

Rachael Lippincott, ALYSON DERRICK

Page: 320

Format: pdf, ePub, mobi, fb2

ISBN: 9788418050312

Publisher: PRH Grupo Editorial

 

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[download pdf] Les Filles du dessous Tome 1
Creators: name: Dimattia
Publisher: name: Zenodo
Year: 2024

description: Les Filles du dessous Tome 1 pan Jean-Charles Gaudin, Siteb, Manon Duverdon

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Les Filles du dessous Tome 1

Jean-Charles Gaudin, Siteb, Manon Duverdon

Nb. de pages: 32

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782380756623

Editeur: Kennes

Date de parution: 2022

 

 

 

Amazon livres audio télécharger Les Filles du dessous Tome 1 (Litterature Francaise) CHM PDB ePub 9782380756623 par Jean-Charles Gaudin, Siteb, Manon Duverdon

 

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Sylvia, chargée de comptabilité et secrétaire de direction dans une société de lingerie, partage un appartement avec sa soeur, Cindy, serveuse dans une boîte de nuit. Cette dernière profite de tous les plaisirs de la vie : elle collectionne les aventures avec les hommes et les expériences sexuelles en tout genre. Lors d'une séance photo visant à promouvoir la nouvelle collection, la mannequin engagée pour l'événement fait un malaise et Sylvia se retrouve à prendre sa place pour sauver la campagne publicitaire. Satisfait du shooting, le gérant du magasin lui donne l'opportunité de créer la prochaine collection de la marque. Cindy, bien décidée à aider sa soeur, lui conseille d'oser un style "coquin" . Pour lui donner de l'inspiration, elle l'emmène alors dans un sexshop un peu particulier...
title:  Pratiche dello ‘stile moderno’ nel cinema delle Americhe
Creators: name: De Vincenti, Giorgio
Publisher: name: Roma TrE-Press
Year: 2016

description: Il saggio propone una definizione di «stile moderno» nel cinema, riflettendo sul rapporto indissolubile fra il linguaggio cinematografico e la materialità del quotidiano con cui entra in contatto. A partire da questa nuova interrogazione portata alla realtà, l’intervento si propone di mappare lo scenario del cinema moderno nelle Americhe successivo alla seconda guerra mondiale, affrontando i legami internazionali fra le figure di maggior spicco e le loro posizioni estetiche e teoriche. La rimappatura si conclude con una riflessione specifica sul cinema statunitense, che intreccia lo stile moderno con la tradizione americana del trascendentalismo filosofico e letterario, come strumento di profonda innovazione oltre che di legame con il territorio e con la concretezza dell’esperienza umana. A titolo di esempio, si è scelto infine di proporre una breve analisi di Route One USA di Robert Kramer, girato a partire da un romanzo di William Least Heat-Moon.
description: Modernità nelle Americhe
(3506) Irina Baronova Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DOWNLOAD [PDF] {EPUB} Le Petit Grevisse  - Grammaire française
Creators: name: Wheeler
Publisher: name: Zenodo
Year: 2024

description: Le Petit Grevisse - Grammaire française pan Maurice Grevisse

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Le Petit Grevisse - Grammaire française

Maurice Grevisse

Nb. de pages: 383

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782801100875

Editeur: Duculot

Date de parution: 2009

 

 

 

Lire de nouveaux livres gratuitement en ligne sans téléchargement Le Petit Grevisse - Grammaire française ePub 9782801100875 (French Edition) par Maurice Grevisse

 

Overview

Utilisé par des générations d'élèves et d'innombrables adultes dans tous les pays de la Francophonie, le petit Grevisse, est une référence incontournable, partout reconnue et appréciée. Son succès est dû à la clarté de l'exposé, à la présentation systématique des règles grammaticales, et à la somme des exemples illustrant chaque cas présenté. La langue, bien sûr, évolue, dans sa structure et son usage. Cette 32e édition, poursuivant l'incessant travail de mise à jour accompli précédemment par Grevisse lui-même, enregistre ces changements, tout en respectant la logique d'ensemble de la grammaire, ainsi que la terminologie familière à la plupart des usagers. Elle propose également une mise en page nouvelle, plus attractive, qui en facilite encore l'utilisation.
[ARTICLE] Gamma Derivatives for the Upgraded Mass-Spring Oscillatory System (Canadian Journal of Mathematics Research / 2023) - GAMMA TRIGONOMETRY
Creators: name: Teia, Luis
Publisher: name: figshare
Year: 2023
Subjects: Dynamics, vibration and vibration control
Mechanical engineering not elsewhere classified
Electrical circuits and systems
Electrical engineering not elsewhere classified
Dynamical systems in applications
Applied mathematics not elsewhere classified
Complex systems
Mathematical physics not elsewhere classified

description: ABSTRACT Derivatives in trigonometry have always been defined in orthogonal contexts (i.e., where the y-axis is set perpendicular to the x-axis). Within the context of trigonometric, the present work expands the concept of derivative (operating by the principle of 90 degrees phase shift when applicable to sine and cosine functions) to the realm where the y-axis is at a variable angle γ to the x-axis (i.e., non-orthogonal systems). This gives rise to the concept of the gamma derivative ― which expands the classical derivative to impart phase shifts of γ degrees. Hence, the ordinary derivative (with respect to α) or d/dα is a particular case of the more general gamma derivative or dγ/dγα. The formula for the nth gamma derivative of the extended sine and cosine functions is defined. For applied mathematics, the gamma derivatives of the extended sine function sin*(α,γ) and cosine function cos*(α,γ) determine the extended governing equation of the energy-coupled mass-spring oscillatory system, and by extended analogy that of the electrical LC (Inductance-Capacitance) circuit.