cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Otitesella swezeyi Fullaway, 1946, new species
Creators: name: Fullaway, D. T.
Publisher: name: Zenodo
Year: 1946
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Torymidae
Otitesella
Otitesella swezeyi

description: 5. Otitesella swezeyi, new species. Female: 1.5 mm. long, metallic green, shagreened, punctuate, the punctuations minute and rather sparse, the mesonotal sculpture appearing as fine transverse striae, basal segments of the antennae and the legs distally from the coxae yellowish brown, eyes red, wings hyaline. Head orbiculate, viewed from above transverse, somewhat menisciform, width about three times the length; occiput, frontovertex, face, and genae forming one continuous moderately convex surface; frontovertex and occiput both rather narrow, the ocelli situate on the former and arranged in form of a very obtuse triangle, the lateral members less than one diameter from eye margin and more than three from the median, anterior member; eyes lateral, oval, long diameter vertical, convex, antennae attached in middle of face, above line drawn from lower margin of eyes, short, not as long as thorax, composed of scape, pedicel, several ring joints, five funicle joints and three-jointed club; the antenna! scrobes are rather deep but short, not nearly reaching the ocelli; the scape is several times longer than wide, pedicel obconic, 1.5 times as long as wide, funicle joints transverse, increasing in thickness outwardly, the club a little more so, its three joints combined less than one half the length of the funicle, both well clothed with short, stiff, gray hairs, cheeks and postgenae fairly wide, the latter narrowing down to the slighter width of the occiput. Thorax twice as long as greatest width, moderately deep, convex dorsally and ventrally, pronotum transverse, wide behind but narrowed in front, quite short; mesonotum considerably wider than long, with well-marked, inwardly (front to back) curved parapsidal grooves and a deep sulcus on the scutellar margin; axillae small; scutellum quite large, scutiform and only moderately convex; metanotum narrow in the middle but widening considerably at sides. Abdomen sessile, as long as thorax and head together, fairly wide basally, compressed from the sides, only the first tergite more or less flat dorsally, the following are knifeedged, sparsely hairy on sides; ovipositor slightly protruded, the valves flat and heavy. Legs normal, the coxae, femora, and tibiae somewhat flattened, of equal length, the tarsi slender and a little longer. Wings fairly wide and long, the veins thin and pale, marginal much shorter than submarginal and twice as long as either the postmarginal or stigma!, which are subequal in length, discal and marginal ciliation inconspicuous. Piti, Oct. 10, ex fruit of small-leaved fig, holotype, Swezey.
description: Published as part of Fullaway, D. T., 1946, Hymenoptera, New Species Of Guam Chalcidoidea, pp. 201-210 in Insects of Guam II, Honolulu, Hawaii :Bernice P. Bishop Museum on pages 204-205, DOI: 10.5281/zenodo.5169330
Characterization of intronic variants in BRCA1 and BRCA2
Creators: name: Pyne, Michael Terry
Publisher: name: University of Utah
Year: 2012
Subjects: Breast Cancer
Mutations

description: Approximately 10% of American women develop breast cancer during their lifetimes. Of the cases of breast cancer, about 10% are attributed to a genetic trait; the remaining appear to be sporadic. Two genes involved in the genetic cases of breast cancer have been discovered in the last decade, BRCAl and BRCA2. Patients who carry a mutation in BRCAl or BRCA2 have an 85% risk during their lifetime of developing breast cancer. Patients with a mutation in BRCAl have a 44% chance of developing ovarian cancer and mutations in BRCA2 are associated with an increased risk of male breast cancer.  Since the discovery of the two breast/ovarian cancer predisposition genes, several thousand patients have been screened for variants in these genes by several methods. Over 700 genetic variants have been reported in BRCAl and over 600 in BRCAl. These variants are categorized as mutations, polymorphisms, or uncertain variants. Mutations have been characterized by their obvious deleterious effects on the protein or by linkage with disease. Polymorphisms have been characterized by their high frequency in the control population and lack of effect on the protein. Uncertain variants can not be placed in either of these two categories. The research described here details work that attempts to characterize those uncertain variants that occur in or near the splice consensus or branch sites and may affect mRNA splicing.  The assay described was developed to provide useful clinical information for patients who had received a test result indicating they carried an uncertain variant. These patients make important decisions regarding their healthcare, surgery, or families, and this extra information would potentially benefit several thousand patients.  The assay involves examining mRNA transcripts of patients who carry uncertain variants and determining if these transcripts are correctly spliced. Also, associations are made that connect the aberrant RNA transcripts to the chromosome carrying the variant. This association is made by tracking the chromosomal contribution to all RNA species through the use of a coding region polymorphism. Wherever possible, genetic haplotype analysis is performed to associate the variant to the defective transcript. If this analysis is not possible, this association is established biochemically using allele-specific amplification and sequencing.  Twenty variants to date have been characterized using this technique. The variants analyzed so far have provided a definitive clinical testing result for over 4000 patients. Although the vast majority of these were attributed to one variant that was determined to be a polymorphism, these patients would have been given an uncertain test result without the results of this new assay and would not know if they were predisposed to breast/ovarian cancer. This assay is a critical part of a comprehensive clinical testing program.
Brief an [Gottfried Kirch]
Creators: name: Wolfsburg, Johann Christian von
Publisher: name: [s.n.]
Year: 1700

description: von Hanns Christian von Wolffsburg
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Mathematical modeling of intraperitoneal drug delivery: simulation of drug distribution in a single tumor nodule
Creators: name: Steuperaert, Margo
name: Labate, Giuseppe Falvo D’Urso
name: Debbaut, Charlotte
name: De Wever, Olivier
name: Vanhove, Christian
name: Ceelen, Wim
name: Segers, Patrick
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration depths are still limited to a few millimeters. It is thus necessary to better understand the limiting factors behind this poor penetration in order to improve IP chemotherapy delivery. By developing a three-dimensional computational fluid dynamics (CFD) model for drug penetration in a tumor nodule, we investigated the impact of a number of key parameters on the drug transport and penetration depth during IP chemotherapy. Overall, smaller tumors showed better penetration than larger ones, which could be attributed to the lower IFP in smaller tumors. Furthermore, the model demonstrated large improvements in penetration depth by subjecting the tumor nodules to vascular normalization therapy, and illustrated the importance of the drug that is used for therapy. Explicitly modeling the necrotic core had a limited effect on the simulated penetration. Similarly, the penetration depth remained virtually constant when the Darcy permeability of the tissue changed. Our findings illustrate that the developed parametrical CFD model is a powerful tool providing more insight in the drug transport and penetration during IP chemotherapy.
Utah physicians' knowledge and perceptions of nurse-midwifery.
Creators: name: Hansen, Jannette Jolley and Mack
Publisher: name: University of Utah
Year: 2012
Subjects: Interprofessional Relations
Professional Competence

description: Birth attendant have been described throughout recorded history.  Professional birth attendants have usually been either female midwives or male physicians. Several studies from the last three decades have explored the relationship between certified nurse-midwives (CNMs) and MDs (medical doctors). This investigation examined Utah physicians' previous experiences with nurse-midwives, knowledge of nurse-midwifery and whether these factors impact perceptions and attitudes they hold toward nurse-midwifery.  The study design was an exploratory survey using a written questionnaire. It was comprised of the total population of physicians thought to be currently practicing obstetrics in Utah.  A 43% overall return rate was obtained, with a 39% unable rate to return. Mean scores were computed for knowledge, satisfaction, and perception.  The mean knowledge score was 5.23 out of 8, indicating a generally good knowledge level concerning CNM practice and education.  The overall man satisfaction score (n=211) falls between neutral and satisfied on the scale.  The responses were positive overall.  The overall mean perception score pertaining to competence of nurse-midwives was generally positive.  Perception scores were compared between respondents with past/present association and those without such associations.  Those with past/present associations consistently scored higher on questions with regard to perception of nurse-midwifery competence.  When asked about benefits and liabilities of having a relationship with a CNM, physician saw benefits as out-weight liabilities.  The two perceived benefits checked most frequently were increased patient satisfaction and attraction of new patients.  The two liabilities most often perceived as detrimental in even a positive CNM/MD relationship were possible increased professional liability and increased malpractice insurance.  Perception of physicians pertaining to appropriateness of employment modes, of CNMs as their employee or as fellow employees in the same institution.  They were in less favor of being partners with CNMs in a practice or having a CNM contact with physicians.  Areas which CNMs and physician might mutually address are: (a) increased knowledge about what each is prepared to do for clients; (b) mutual expectations of the collaborative relationship; and (c) education of young physicians regarding the role of the CNM.
Brief an Johann Bernoulli
Creators: name: Weiss, Ferenc
Publisher: name: [s.n.]
Year: 1773

description: von Franz Weiss
description: Enthält Notiz von Bernoulli
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 23: Astronomische Beobachtungen
Brief an [Gottfried] Kirch
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1684

description: von Joh[ann] Wölffing
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an Gottfried Kirch
Creators: name: Wölffing, Johann
Publisher: name: [s.n.]
Year: 1683

description: von Joh[ann] Wölffing
description: Mit braunem Siegel
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Automatic catalog construction for product search engines
Creators: name: Nguyen, Hoa Thanh
Publisher: name: University of Utah
Year: 2012
Subjects: Database
Data integration
Deep web
E-commerce
Machine learning
Schema matching

description: With the steady increase in online shopping, more and more consumers are resorting to Product Search Engines and shopping sites such as Yahoo! Shopping, Google Product Search, and Bing Shopping as their first stop for purchasing goods online. These sites act as intermediaries between shoppers and merchants to drive user experience by enabling faceted search, comparison of products based on their specifications, and ranking of products based on their attributes.  The success of these systems heavily relies on the variety and quality of the products that they present to users. In that sense, product catalogs are to online shopping what the Web index is to Web search. Therefore, comprehensive product catalogs are fundamental to the success of Product Search Engines. Given the large number of products and categories, and the speed at which they are released to the market, constructing and keeping catalogs up-to-date becomes a challenging task, calling for the need of automated techniques that do not rely on human intervention.  The main goal of this dissertation is to automatically construct catalogs for product search engines. To achieve this goal, the following problems must be addressed by these search engines: (i) product synthesis-creation of product instances that conform with the catalog schema; (ii) product discovery- derivation of product instances for products whose schemata are not present in the catalog; (iii) schema synthesis- construction of schemata for new product categories. We propose an end-to-end framework that automates, to a great extent, these tasks. We present a detailed  experimental evaluation using real data sets which shows that our framework is effective, scaling to  a large number of products and categories, and resilient to noise that is inherent in Web data.
Microfluidic DNA extraction and quantification using a nanoporous membrane and flow rate analysis
Creators: name: Surapaneni, Rajesh
Publisher: name: University of Utah
Year: 2012
Subjects: gDNA

description: A genomic DNA (gDNA) extraction and quantification system using flow rate  analysis was designed and fabricated using a nanoporous membrane-embedded  microfluidic system. A nanoporous aluminum oxide membrane was embedded in a  microfluidic system that was fabricated using a PDMS/tape composite. To prove the  concept of the system, 370nm nanoparticles were used and extracted on a membrane with  200nm pores. As nanoparticles collect on the membrane, the flow rate initially decreases  linearly before switching to an exponential decrease. In a similar manner, a gDNA  sample was flowed and trapped on the membrane and the measured flow rate change was  used to evaluate the mass of gDNA on the membrane. After preliminary testing, gDNA  of 6.25ng/(al, 12.5ng/ul, 18.75ng/|ul and 25ng/^l concentrations were extracted over  20nm pore sized membranes and a similar flow rate profile was observed. As the amount  of gDNA trapped on the membrane increases, the pressure drop in the microfluidic  system increases. Using the experimental data, one can develop an empirical formula for  the mass of gDNA collected and the concentration of gDNA in the sample. From this  empirical equation, it is possible to estimate the gDNA sample concentration from the  measured flow rate change caused by an unknown sample. By integrating this system  with a microfluidic gDNA sample preparation system, we not only extract gDNA, but  also quantify the mass of gDNA collected, which allows for operators to end tests that will clearly be negative or allows operators to extend the extraction process until  sufficient nucleic acid material is obtained.
Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery – comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution
Creators: name: Ishak, Rania A. H.
name: Mostafa, Nada M.
name: Kamel, Amany O.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: The blood–brain barrier is considered the leading physiological obstacle hindering the transport of neurotherapeutics to brain cells. The application of nanotechnology coupled with surfactant coating is one of the efficacious tactics overcoming this barrier. The aim of this study was to develop lipid polymer hybrid nanoparticles (LPHNPs), composed of a polymeric core and a phospholipid shell entangled, for the first time, with PEG-based surfactants (SAA) viz. TPGS or Solutol HS 15 in comparison with the gold standard Tween 80, aiming to enhance brain delivery and escape opsonization. LPHNPs were successfully prepared using modified single-step nanoprecipitation technique, loaded with the flavonoid rutin (RU), extracted from the flowers of Calendula officinalis L., and recently proved as a promising anti-Alzheimer. The effect of the critical process parameters (CPP) viz. PLGA amount, Wlecithin/WPLGA ratio, and Tween 80 concentration on critical quality attributes (CQA); entrapment, size and size distribution, was statistically analyzed via design of experiments, and optimized using the desirability function. The optimized CPP were maintained while substituting Tween 80 with other PEG-SAA. All hybrid particles exhibited spherical shape with perceptible lipid shells. The biocompatibility of the prepared NPs was confirmed by hemolysis test. The pharmacokinetic assessments, post-intravenous administration to rats, revealed a significant higher RU bioavailability for NPs relative to drug solution. Biodistribution studies proved non-significant differences in RU accumulation within brain, but altered phagocytic uptake among various LPHNPs. The present study endorses the successful development of LPHNPs using PEG-SAA, and confirms the prospective applicability of TPGS and Solutol in enhancing brain delivery.
Sonnenfleckenzeichnung Nr. 23445.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Development of low-temperature performance specifications for asphalt pavements using the bending beam rheometer
Creators: name: Jones, ZacGary Leon
Publisher: name: University of Utah
Year: 2013
Subjects: Asphalt
BBR
cracking
low-temperature
performance

description: Thermal cracking due to stress at low temperature is a major factor in roadway degradation. The purpose of this study was to measure low temperature response of asphalt from field cores, assess the practicality of using the Bending Beam Rheometer (BBR) to test field mixtures, compare test results to observed field performance, determine whether a specification value can be obtained to evaluate low-temperature pavement performance, and determine if samples constructed in the laboratory using the same mix design reflect field performance. In this study the BBR was used to test multiple field and laboratory asphalt mixtures. Field samples were obtained from cores located in the Salt Lake Valley in Utah. Laboratory samples were constructed for all sections with available materials. The response of field cores showed that although the same binder grade is used in the region, the resulting mixtures have significant differences in creep moduli and m-values. This indicates that binder testing alone might not be enough to control the material's creep modulus. The combination of BBR test results and field surveys indicates that both creep modulus and m-value play a significant role in low-temperature performance of asphalt pavements. Pavements with high creep moduli and low m-values are more susceptible to low-temperature thermal distress. From field observations, the field performance of each iv section was known; by plotting the test results of the field samples on a Black Space diagram it can be observed that a thermal stress failure envelope might exist. However, more research will be necessary to further define this specification. Results show that lab samples are not always representative of field construction samples. Although the same mix design and sample preparation protocol was used, the results vary widely. It is recommended that all sections that displayed a creep modulus/m-value relationship near the possible thermal stress failure envelope continue to be monitored for thermal distress. It is also recommended that future research focuses on pavements with similar designs which show thermal distress to verify the conclusion, which states that pavements with high creep moduli and low m-values are more prone to thermal distress.
Cholesterol-conjugated poly(D, L-lactide)-based micelles as a nanocarrier system for effective delivery of curcumin in cancer therapy
Creators: name: Kumari, Preeti
name: Muddineti, Omkara Swami
name: Rompicharla, Sri Vishnu Kiran
name: Ghanta, Pratyusha
name: N, Adithya Karthik B B
name: Ghosh, Balaram
name: Biswas, Swati
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Polymeric micelles have been widely explored preclinically as suitable delivery systems for poorly soluble chemotherapeutic drugs in cancer therapy. The present study reported the development of cholesterol (Ch)-conjugated poly(D,L-Lactide) (PLA)-based polymeric micelles (mPEG–PLA-Ch) for effective encapsulation and delivery of curcumin (CUR) at the tumor site. Cholesterol conjugation dramatically affected the particle size and improved drug loading (DL) and encapsulation efficiency (EE). mPEG–PLA-Ch-CUR showed bigger hydrodynamic diameter (104.6 ± 2.1 nm, and 169.3 ± 1.52 nm for mPEG–PLA and mPEG–PLA-Ch, respectively) due to increased size of the hydrophobic core. The newly developed polymer exhibited low critical micelles concentration (CMC) (25 μg/mL) which is close to lipid-based polymer, PEG-phosphatidyl ethanolamine (12.5 μg/mL) compared to mPEG–PLA (50 μg/mL). mPEG–PLA-Ch micelles exhibited relatively higher EE (93.74 ± 1.6%) and DL (11.86 ± 0.8%) compared to mPEG–PLA micelles (EE 91.89 ± 1.2% and DL 11.06 ± 0.8%). mPEG–PLA-Ch micelles were internalized by the cancer cells effectively and exhibited higher cytotoxicity compared to free CUR in both, murine melanoma (B16F10) and human breast cancer (MDA-MB-231) cells. mPEG–PLA-Ch exhibited satisfactory hemocompatibility indicating their potential for systemic application. Further, mPEG–PLA-Ch-CUR demonstrated higher rate of reduction of tumor volume in B16F10-xenografted tumor-bearing mice compared to free CUR. At the end of 22 days, the tumor reduced to 1.87-fold (627.72 ± 0.9 mm3 versus 1174.68 ± 1.64 mm3) compared to the treatment with free CUR. In conclusion, the experimental data in vitro and in vivo indicated that the newly developed CUR-mPEG–PLA-Ch micelles may have promising applications in solid tumors.
Mathematical modeling of intraperitoneal drug delivery: simulation of drug distribution in a single tumor nodule
Creators: name: Steuperaert, Margo
name: Labate, Giuseppe Falvo D’Urso
name: Debbaut, Charlotte
name: Wever, Olivier De
name: Vanhove, Christian
name: Ceelen, Wim
name: Segers, Patrick
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration depths are still limited to a few millimeters. It is thus necessary to better understand the limiting factors behind this poor penetration in order to improve IP chemotherapy delivery. By developing a three-dimensional computational fluid dynamics (CFD) model for drug penetration in a tumor nodule, we investigated the impact of a number of key parameters on the drug transport and penetration depth during IP chemotherapy. Overall, smaller tumors showed better penetration than larger ones, which could be attributed to the lower IFP in smaller tumors. Furthermore, the model demonstrated large improvements in penetration depth by subjecting the tumor nodules to vascular normalization therapy, and illustrated the importance of the drug that is used for therapy. Explicitly modeling the necrotic core had a limited effect on the simulated penetration. Similarly, the penetration depth remained virtually constant when the Darcy permeability of the tissue changed. Our findings illustrate that the developed parametrical CFD model is a powerful tool providing more insight in the drug transport and penetration during IP chemotherapy.
Entropy and exclusivity: gender and change in the retail environment, Alexandria, Egypt (1970-2011)
Creators: name: Snider, Marika Dalley
Publisher: name: University of Utah
Year: 2013
Subjects: Alexandria, Egypt
Gender
Informal economy
Malls
Modernity
Retail space

description: As one of the most visible signs of the modern world, the myriad of shopping places and types can be considered as a valuable lens through which to examine the contemporary city. In Alexandria, Egypt, the situation was particularly interesting because retail space was moving in two polarized directions: exclusivity and entropy. First, there was an emphasis on creating high-end restricted modern space while at the same time, low-end retail, both modern and traditional, were proliferating and becoming less organized. The high-end modern retail created exclusive spaces in which traditional forms of gendered space could be upheld, although in a reconfigured manner. On the other hand, the proliferation of lower-end retail space allowed greater female participation in consumerism but in an increasingly insecure situation. Insecurity took many forms including lack of personal safety, price volatility, unpredictable earnings, and an unreliable supply of goods. This dissertation will examine how the retail spaces in Alexandria affected gendered space and how ideas about space were reconfigured to allow women to navigate the modern globalized world without abandoning their status or virtue. This research specifically targets the difference between the shopping mall, as the embodiment of high-end retail, and the urban shopping street, as popular retail space. Through these two environments, we will see how they are defined in opposition to each other, particularly in terms of status, and their appropriateness for women, and how they are gendered differently. Specifically this research will examine the extent to which the genders mix, in terms of goods sold, shoppers, and shop workers, as well as the extent to which women are allowed privacy. This will show how the retail environment of Alexandria responded to its citizens' desires to be modern and globalized through both the creation of exclusive spaces and devolution into chaotic zones.
title: Osseointegration and biocompatibility of titanium implants
Creators: name: Gibbs, Alex
Publisher: name: URMSE
Year: 2020

description: Orthopedic implants are a growing field of modern medicine at which titanium is at the forefront. Titanium offers favorable surface modification, phase control, and mechanical properties. A challenge of orthopedic implants is the osseointegration and biocompatibility of the implant. The following pages review recent advancements in improving the osseointegration and biocompatibility of titanium implants with bone.
Sonnenfleckenzeichnung Nr. 23346.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
The Effects of early hospital discharge on maternal and infant outcomes
Creators: name: Lemmer, Corinne Marie
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Postpartum:

description: The effects of early hospital discharge of maternal and infant outcomes were studies by interviewing 21 primiparas choosing early discharge and a comparison group of 21 primparas with hospital stays longer than 24 hours.  At 1 week postpartum, maternal and infant health status was assessed and information on factors motivating choice-of early discharge and about intensity of concerns was gathered by questionnaire.  Results showed no significant differences between groups with respect to medical outcome and intensity of concerns.  A significantly greater number of infants in the early discharge group received medical supervision for jaundice.  Women in the early discharge group had greater recall of prenatal learning, more support following discharge, and ranked a statistically significant fewer number of items of concerns as much concern.  Findings support the need for greater nursing intervention during the pureperium and research evaluating programs designed to facilitate learning and postpartal adjustment of new parents
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.08.1970, erstellt von Emilia Tifrea, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery – comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution
Creators: name: Ishak, Rania A. H.
name: M. Mostafa, Nada
name: Kamel, Amany O.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: The blood–brain barrier is considered the leading physiological obstacle hindering the transport of neurotherapeutics to brain cells. The application of nanotechnology coupled with surfactant coating is one of the efficacious tactics overcoming this barrier. The aim of this study was to develop lipid polymer hybrid nanoparticles (LPHNPs), composed of a polymeric core and a phospholipid shell entangled, for the first time, with PEG-based surfactants (SAA) viz. TPGS or Solutol HS 15 in comparison with the gold standard Tween 80, aiming to enhance brain delivery and escape opsonization. LPHNPs were successfully prepared using modified single-step nanoprecipitation technique, loaded with the flavonoid rutin (RU), extracted from the flowers of Calendula officinalis L., and recently proved as a promising anti-Alzheimer. The effect of the critical process parameters (CPP) viz. PLGA amount, Wlecithin/WPLGA ratio, and Tween 80 concentration on critical quality attributes (CQA); entrapment, size and size distribution, was statistically analyzed via design of experiments, and optimized using the desirability function. The optimized CPP were maintained while substituting Tween 80 with other PEG-SAA. All hybrid particles exhibited spherical shape with perceptible lipid shells. The biocompatibility of the prepared NPs was confirmed by hemolysis test. The pharmacokinetic assessments, post-intravenous administration to rats, revealed a significant higher RU bioavailability for NPs relative to drug solution. Biodistribution studies proved non-significant differences in RU accumulation within brain, but altered phagocytic uptake among various LPHNPs. The present study endorses the successful development of LPHNPs using PEG-SAA, and confirms the prospective applicability of TPGS and Solutol in enhancing brain delivery.
Reflections on methodological tensions in doing qualitative research at the science-policy-community interface
Creators: name: Brennan, Ruth
Publisher: name: Zenodo
Year: 2020

description: Carrying out qualitative, participatory research at the science-policy-community interface can yield methodological tensions and present challenges for researchers. Sitting within the broader context of a long-running debate around the desirability of scholars’ engagement with the policy environment, the chapter conceptualises three tensions that emerge at the science-policy-community interface, between: process and outcome; engaged research and advocacy; and applied policy research and critical theoretical research. It calls for greater attention to the energy, skills and time it takes to forge the relationships needed to do impactful research and for wider institutional support for policy-engaged academics.
MPEC 2024-J67 : 2024 JJ1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 JJ1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Mapping of Possible Pathways to Sustainable Design in Social Robotics.
Creators: name: Hägglund, Susanne
name: Andtfolk, Malin
name: Rosenberg, Sara
name: Andersson, Sören
name: Nyholm, Linda
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Sustainability sciences
subject: Health care sciences
subject: Medical and health sciences
subject: FOS: Medical and health sciences
subject: Artificial intelligence

description: It’s imperative that all sectors adapt to global warming, including technology designers and researchers exploring social robotics in healthcare. However, sustainability is a complex concept, and its operationalization mechanisms are not easily defined.

In this document, we share a collaborative team reflection of possible pathways to sustainable design of an AI-augmented, socially assistive robot prototype application. Our mapping suggests that empirical and conceptual studies, within the research and design team and with stakeholders, may address all three dimensions of sustainability - environmental, economic, and social - at a micro, meso, and macro level.

The map of possible pathways is neither a complete list nor a silver bullet to a fully sustainable technological solution. Nonetheless, we hope that it furthers the discussion regarding possible ways to include sustainability as a tool in the design box and to research sustainable design in social robotics.
Surface integrity in machined aluminum alloys: effects of cutting tool coatings and cooling/lubrication
Creators: name: Juturu, Raga Madhuri
Publisher: name: University of Utah
Year: 2012
Subjects: Aluminum
Coatings
Hole-drilling strain-gage method
Lubrication
Machining
Surface integrity

description: Manufacturing processes significantly influence the type of surface that is being produced. The quality of the surface dictates the functional performance and service-life of engineered components. Residual stresses and surface roughness are some of the important constituents of these manufactured surfaces. Hence, knowledge about factors that cause residual stresses will contribute to a better fundamental understanding of  manufacturing process mechanics and improved knowledge-driven manufacturing process planning.
Docosahexaenoic acid–mediated, targeted and sustained brain delivery of curcumin microemulsion
Creators: name: Shinde, Rajshree L.
name: Devarajan, Padma V.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: We disclose microemulsions (ME) of curcumin (CUR) with docosahexaenoic acid (DHA)-rich oil (CUR DHA ME) for targeted delivery to the brain. MEs of CUR (5 mg/mL) with and without DHA-rich oil (CUR Capmul ME) suitable for intravenous and intranasal administration exhibited negative zeta potential, globule size <20 nm and good stability. Following intravenous delivery MEs exhibited high brain concentration with CUR DHA ME exhibiting a 2.8-fold higher Cmax than CUR solution. Furthermore, high and sustained concentration was demonstrated even at 24 h, which was 8- and 2-fold higher than CUR solution and CUR Capmul ME, respectively. Brain concentrations following intranasal administration were, however, substantially higher as evident from higher Cmax and AUC and sustained compared to corresponding intravenous formulations signifying nose to brain targeting. The high brain concentration of CUR DHA ME is ascribed to the targeting efficiency enabled by DHA-mediated transport across the blood–brain barrier (BBB). Histopathological and nasal toxicity confirmed safety of the MEs. Concentration-dependent cytotoxicity in vitro, on human glioblastoma U-87MG cell line was observed with CUR DHA MEs and with the blank DHA ME, implying anticancer potential of DHA. The dramatically low IC50 value of CUR DHA ME (3.755 ± 0.24 ng/mL) is therefore attributed to the synergistic effect of CUR and DHA in the ME. The CUR concentration achieved with CUR DHA ME at 24 h which translated to >66-fold(intranasal) and >21–fold (intravenous) the IC50 value in the U-87MG cell line suggests great promise of CUR DHA ME for therapy of brain cancer by both routes.
Religiousness and spirituality as moderators of physiological responses to social evaluative threat
Creators: name: Jordan, Kevin David
Publisher: name: University of Utah
Year: 2014

description: A growing body of evidence suggests that individual differences in religiousness and spirituality (R/S) predict important health outcomes; however, the processes explaining these effects are not well understood. Specific physiological stress mechanisms have been hypothesized as potential mediators of the R/S - health relationship. Provided there has been exposure to a stressful event or stimulus, R/S may influence reactivity in the cardiovascular and neuroendocrine systems. A number of studies have found that some aspects of R/S attenuated or potentiated physiological responses to stress, but they have not used a conceptual perspective from which to organize and understand the effects of taxing social circumstances. Using social self-preservation theory and the interpersonal theory of personality, social, and clinical psychology, the present study examined the association of various aspects of R/S with emotional and physiological reactivity and recovery in response to social-evaluative threats involving agency (i.e., striving for achievement and status) and communion (i.e., striving for connection with others). Multiple aspects of R/S were assessed (and reduced via factor analysis) to examine their moderating effect on emotional and physiological responses during and after two types of social-evaluative threat. Emotional responses included self-reported anxiety and shame. Physiological iv responses included salivary cortisol, heart rate, and systolic/diastolic blood pressure, all of which are widely studied mechanisms in studies of psychosocial vulnerability. Overall, social evaluative threat led to psychophysiological reactivity (e.g., increased anxiety, increased self-conscious emotions), and increased cardiovascular and neuroendocrine (i.e., cortisol) reactivity, all of which is consistent with social self-preservation theory. Contrary to predictions, the R/S factors generally did not predict emotional and physiological responses, and did not moderate the effects of stress. These results are somewhat surprising given the warm interpersonal style associated with R/S. Possible reasons for these null findings are discussed. These include the use of self-report to assess R/S, the limited relevance of the stressor to R/S individuals, and other considerations. R/S could influence health and well-being more so through day-to-day stress exposure, which was not assessed in the present study. Future studies are recommended such as daily diary protocols in which day-to-day stress exposure can be assessed.
Synthesis, characterization, and experimental investigation of photonic crystals derived from biology
Creators: name: Jorgensen, Matthew Ray
Publisher: name: University of Utah
Year: 2012
Subjects: Biomimetic
Density of optical states
Photonic crystals
Radiative lifetime

description: The synthesis, characterization, and nonclassical optical properties of photonic crystals (PCs) created from naturally occurring biological templates was studied. Biotemplated PCs were created from several different natural structures using sol-gel chemistry methods. PCs were characterized using a combination of reflection  spectroscopy, SEM image analysis, three-dimensional structure modeling, photonic band structure calculations, and density of optical states calculations. The effect our PCs had on the density of optical states (DOS) was probed using time correlated single photon counting spectroscopy.  By carefully controlling the sol-gel chemistry used in the templating process, it is possible to synthesize hollow silica inverse, solid silica inverse, hollow titania inverse,  solid titania inverse, and solid titania replicate structures. The inverse-type structures have the advantage of being accessible through a single templating step, while the titania replica is capable of a predicted full photonic band gap. Each structure was investigated using methods mentioned above.  The reliability of reflectance spectroscopy was investigated. It was found that in certain cases, a continuum of structural parameters yield reflections that match photonic band structure calculations. Methods to improve this situation are discussed. When applied to titania inverse opals, it was found that the refractive index could be determined to ±0.05 and the volume fraction to ±0.5%. Accurately determining the refractive index of inverse opals is useful in estimating the refractive index of other PCs made from the same sol-gel.  Calculation of the DOS using a combination of MIT's photonic bands package and house-written software was applied to biotemplated photonic crystals. It was found  that even partial band gap photonic crystals can greatly modify the DOS.  Finally, the rate of spontaneous emission of quantum dots embedded in photonic crystals was measured to indirectly probe the DOS. Three different models were used to extract the lifetime from radiative decay curves. It was found that a log-normal distribution of lifetimes was the most meaningful model. The radiative lifetime of  quantum dots embedded in titania photonic crystals replicated from Lamprocyphus augustus was modified by up to a factor of ten, an amount unprecedented in the photonic crystal literature.
Sonnenfleckenzeichnung Nr. 23396.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel