cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
WHOLE EXOME SEQUENCING (WES) IN CLINICAL DIAGNOSTICS - CHALLENGES AND OPPORTUNITIES
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Genomic Revolution
Whole Exome Sequencing (WES)
Precision Medicine
Clinical Diagnostics
Genetic Variation
Data Interpretation
Ethical Considerations
Collaborative Solutions
Rare Diseases
Healthcare Transformation

description: The Genomic Revolution is reshaping healthcare, with Whole Exome Sequencing (WES) emerging as a transformative tool in clinical diagnostics. This article explores WES's potential to revolutionize personalized medicine, presenting insights into its clinical applications, challenges, and collaborative solutions. Methodologically, a systematic review was conducted, focusing on the last decade's literature from reputable databases. Challenges in data interpretation, ethical considerations, cost-effectiveness, and accessibility are addressed, alongside collaborative efforts to bridge these gaps. Results highlight WES's impact on personalized medicine, advancements in rare disease diagnosis, and its role in cancer genomics. Ethical concerns, particularly regarding informed consent and data privacy, are acknowledged. The article concludes by emphasizing the need for continued research, international collaboration, and ethical frameworks to unlock the full potential of WES in clinical genomics, promising a future of precise diagnostics and improved healthcare outcomes.

 

Die genomische Revolution verändert das Gesundheitswesen, wobei sich die Whole Exome Sequencing (WES) zu einem transformativen Werkzeug in der klinischen Diagnostik entwickelt. Dieser Artikel untersucht das Potenzial von WES, die personalisierte Medizin zu revolutionieren, und präsentiert Einblicke in seine klinischen Anwendungen, Herausforderungen und kollaborativen Lösungen. Methodisch wurde eine systematische Überprüfung durchgeführt, die sich auf die Literatur des letzten Jahrzehnts aus seriösen Datenbanken konzentrierte. Herausforderungen bei der Dateninterpretation, ethischen Überlegungen, Kosteneffizienz und Zugänglichkeit werden angegangen und es werden gemeinsame Anstrengungen unternommen, um diese Lücken zu schließen. Die Ergebnisse unterstreichen den Einfluss von WES auf die personalisierte Medizin, Fortschritte bei der Diagnose seltener Krankheiten und seine Rolle bei der Krebsgenomik. Ethische Bedenken, insbesondere hinsichtlich der Einwilligung nach Aufklärung und des Datenschutzes, werden anerkannt. Der Artikel schließt mit der Betonung der Notwendigkeit kontinuierlicher Forschung, internationaler Zusammenarbeit und ethischer Rahmenbedingungen, um das volle Potenzial von WES in der klinischen Genomik auszuschöpfen und eine Zukunft mit präziser Diagnostik und verbesserten Gesundheitsergebnissen zu versprechen.
Jonquières maps and $\mathrm{SL}(2;\mathbb{C})$-cocycles
Creators: name: Déserti, Julie
Publisher: name: arXiv
Year: 2013
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37F10, 14E07

description: We start the study of the family of birational maps $(f_{α,β})$ of $\mathbb{P}^2_\mathbb{C}$ in \cite{Deserti}. For generic $α$ and $β$ of modulus 1 the centraliser of $f_{α,β}$ is trivial, the topological entropy of $f_{α,β}$ is 0, there exist two areas of linearisation: in the first one the closure of the orbit of a point is a torus, in the other one the closure of the orbit of a point is the union of two circles. On $\mathbb{P}^1_\mathbb{C}\times \mathbb{P}^1_\mathbb{C}$ any $f_{α,β}$ can be viewed as a cocyle; using recent results about $\mathrm{SL}(2;\mathbb{C})$-cocycles (\cite{Avila}) we determine the \textsc{Lyapunov} exponent of the cocyle associated to $f_{α,β}$.
description: Proof of Theorem A has been detailed
Fundamental Membranes and the String Dilaton
Creators: name: Meissner, Krzysztof A.
name: Nicolai, Hermann
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the quantization of the bosonic sector of supermembrane theory in double dimensional reduction, in order to extract the dependence of the resulting world-sheet action on the string dilaton (which cannot be obtained from a purely kinematic reduction). Our construction relies on a Polyakov-type approach with all six metric components on the world-volume as independent quantum fields, and shows that the correct and unique answer is only obtained if the target-space dimension of the theory is restricted to the critical value ($D=11$ for the supermembrane). As a corollary, our analysis implies that there are no analogs of the non-critical string for (super-)membrane theory.
description: equations (1) and (21) corrected, one reference added
The Embedded Transparent Lens and Fermat's Least-Time Principle
Creators: name: Kantowski, Ronald
name: Chen, Bin
name: Dai, Xinyu
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a simplified version of the lowest-order embedded point mass gravitational lens theory and then make the extension of this theory to any embedded transparent lens. Embedding a lens effectively reduces the gravitational potential's range, i.e., partially shields the lensing potential because the lens mass is made a contributor to the mean mass density of the universe and not simply superimposed upon it. We give the time-delay function for the embedded point mass lens from which we can derive the simplified lens equation by applying Fermat's least-time principle. Even though rigorous derivations are only made for the point mass in a flat background, the generalization of the lens equation to lowest-order for any distributed lens in any homogeneous background is obvious. We find from this simplified theory that embedding can introduce corrections above the few percent level in weak lensing shears caused by large clusters but only at large impacts. The potential part of the time delay is also affected in strong lensing at the few percent level. Additionally we again confirm that the presence of a cosmological constant alters the gravitational deflection of passing photons.
description: 15 pages, 3 figures, Phys. Rev. D, in press
Continuous Spectrum on Cosmological Collider
Creators: name: Aoki, Shuntaro
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the effects of a massive field with a continuous spectrum (continuum isocurvaton) on the inflationary bispectrum in the squeezed limit. As a concrete example, we extend the quasi-single field inflation model to include a continuum isocurvaton with a well-motivated spectral density from extra dimensions and focus on a contribution to the bispectrum with a single continuum isocurvaton exchange. In contrast to the usual case without the continuous spectrum, the amplitude of the bispectrum has a damping feature in the deep squeezed limit, which can be strong evidence for the continuous spectrum.
description: 23 pages, 3 figures; v2: references added, to be published in Journal of Cosmology and Astroparticle Physics
title: Σχεδίαση και υλοποίηση ενδιάμεσου λογισμικού σε P-Grid δίκτυα ανεκτικά σε λάθη
Creators: name: Βουρλάκης Νικόλας
Publisher: name: Technical University of Crete
Year: 2013

description: Μη διαθέσιμο
Klaus Geus: Eratosthenes von Kyrene. Studien zur hellenistischen Kultur- und Wissenschaftsgeschichte
Creators: name: Lobe, Michael
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Klaus Geus: Eratosthenes von Kyrene. Studien zur hellenistischen Kultur- und Wissenschaftsgeschichte. (Münchener Beiträge zur Papyrusforschung und antiken Rechtsgeschichte, 92. Heft), München, C.H.Beck 2002, 412 S. (ISBN 3 406 489 761).
description: Forum Classicum, Nr. 2 (2002): Forum Classicum
title: Σεισμική καταπόνηση Χ.Υ.Τ.Α.
Creators: name: Ζανιά Βαρβάρα
Publisher: name: Technical University of Crete
Year: 2009

description: 1.Εισαγωγή -- 2.Βιβλιογραφική ανασκόπηση -- 3.Καταπόνηση Χ.Υ.Τ.Α. λόγω ενεργοποίησης υποκείμενου ρήγματος -- 4.Δυναμική απόκριση Χ.Υ.Τ.Α. -- 5.Σεισμική ευστάθεια πρανών Χ.Υ.Τ.Α.:απλοποιητικές μεθοδολογίες -- 6.Σεισμική ευστάθεια πρανών Χ.Υ.Τ.Α.:λεπτομερής αριθμητική προσομοίωση -- 7.Συμπεράσματα-προτάσεις
Joint reconstruction-segmentation on graphs
Creators: name: Budd, Jeremy
name: van Gennip, Yves
name: Latz, Jonas
name: Parisotto, Simone
name: Schönlieb, Carola-Bibiane
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences
subject: 05C99, 34B45, 35R02, 65F60, 94A08

description: Practical image segmentation tasks concern images which must be reconstructed from noisy, distorted, and/or incomplete observations. A recent approach for solving such tasks is to perform this reconstruction jointly with the segmentation, using each to guide the other. However, this work has so far employed relatively simple segmentation methods, such as the Chan--Vese algorithm. In this paper, we present a method for joint reconstruction-segmentation using graph-based segmentation methods, which have been seeing increasing recent interest. Complications arise due to the large size of the matrices involved, and we show how these complications can be managed. We then analyse the convergence properties of our scheme. Finally, we apply this scheme to distorted versions of ``two cows'' images familiar from previous graph-based segmentation literature, first to a highly noised version and second to a blurred version, achieving highly accurate segmentations in both cases. We compare these results to those obtained by sequential reconstruction-segmentation approaches, finding that our method competes with, or even outperforms, those approaches in terms of reconstruction and segmentation accuracy.
description: 33 pages, 20 figures
Use of rainfall and sea surface temperature monitoring for malaria early warning in Botswana
Creators: name: Thomson, Madeleine C.
name: Mason, Simon J.
name: Phindela, Thandie
name: Connor, Stephen J.
Publisher: name: Columbia University
Year: 2005
Subjects: Malaria
Malaria--Prevention
Climatic changes
Climatic changes--Models
Epidemics--Prevention

description: Improved prediction, prevention, and control of epidemics is a key technical element of the Roll Back Malaria partnership. We report a methodology for assessing the importance of climate as a driver of inter-annual variability in malaria in Botswana, and provide the evidence base for inclusion of climate information in a national malaria early warning system. The relationships of variability in rainfall and sea surface temperatures (SSTs) to malaria incidence are assessed at the national level after removing the impact of non-climatic trends and a major policy intervention. Variability in rainfall totals for the period December–February accounts for more than two-thirds of the inter-annual variability in standardized malaria incidence in Botswana (January–May). Both rainfall and annual malaria anomalies in December–February are significantly related to SSTs in the eastern Pacific, suggesting they may be predictable months in advance using seasonal climate forecasting methodologies.
Enhanced Surface Second Harmonic Generation in Nanolaminates
Creators: name: Abtahi, Fatemeh
name: Paul, Pallabi
name: Beer, Sebastian
name: Kuppadakkath, Athira
name: Pakhomov, Anton
name: Szeghalmi, Adriana
name: Nolte, Stefan
name: Setzpfandt, Frank
name: Eilenberger, Falk
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Second-harmonic generation (SHG) is a second-order nonlinear optical process that is not allowed in media with inversion sym-metry. However, due to the broken symmetry at the surface, surface SHG still occurs, but is generally small. We experimentally investi-gate the surface SHG in periodic stacks of alternating, subwave-length dielectric layers, which have a large number of surfaces, thus enhancing surface SHG considerably. To this end, multilayer stacks of SiO2/TiO2 were grown by Plasma Enhanced Atomic Layer Deposition (PEALD) on fused silica substrates. With this technique individual layers of a thickness of less than 2 nm can be fabricated. We experimentally show that under large angles of incidence (> 20 degrees) there is substantial SHG, well beyond the level, which can be observed from simple interfaces. We perform this experiment for samples with different periods and thickness of SiO2/TiO2 and our results are in agreement with theoretical calculations.
Conserved asymptotic charges for any massless particle
Creators: name: Nguyen, Kevin
name: West, Peter
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the conserved charges associated with the asymptotic symmetries of massless particles by examining their free theory in Minkowski spacetime. We give a procedure to systematically deduce the fall off of the massless fields at spatial infinity and show that it has a universal behaviour when expressed in tangent space. We do this for generic massless particles. We do not impose gauge fixing conditions which allows us to uncover new nonzero charges for the graviton beyond the well-known supertranslation charges. We also compute conserved charges in the dual formulations of certain low spin particles and argue that this leads to an infinite number of new conserved charges.
description: 25 pages. In this new version we added an acknowledgement, namely The work of KN is supported by the ERC Consolidator Grant N. 681908, Quantum black holes: A microscopic window into the microstructure of gravity
Multiplicité du spectre de Steklov sur les surfaces et nombre chromatique
Creators: name: Jammes, Pierre
Publisher: name: arXiv
Year: 2013
Subjects: subject: Differential Geometry (math.DG)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics

description: We prove several results about the multiplicity of the first Steklov eigenvalues on compact surfaces with boundary. We improve some bounds on the multiplicity, especially for the first eigenvalue, and we prove they are sharp on some surfaces of small genus. In a previous article, we defined a new chromatic invariant of surfaces with boundary and conjectured that this invariant is related to the bound on the first eigenvalue. In the present article, we study this invariant, and prove that the conjecture is true when the known bound is sharp.
description: in French, v3: Minor corrections
title: Ανάλυση ιχνοστοιχείων με εκλεκτική ακινητοποίηση σε ανακλαστήρες ακτίνων Χ
Creators: name: Αρετάκη Ιωάννα-Νικόλ
Publisher: name: Technical University of Crete
Year: 2011

description: Μη διαθέσιμο
Malaria early warnings based on seasonal climate forecasts from multi-model ensembles
Creators: name: Thomson, Madeleine C.
name: Doblas-Reyes, Francesco
name: Mason, Simon J.
name: Hagedorn, Renate
name: Connor, Stephen J.
name: Phindela, Thandie
name: Palmer, Timothy
Publisher: name: Columbia University
Year: 2006
Subjects: Malaria
Malaria--Prevention
Climatic changes
Climatic changes--Models
Epidemics--Prevention

description: The control of epidemic malaria is a priority for the international health community and specific targets for the early detection and effective control of epidemics have been agreed. Interannual climate variability is an important determinant of epidemics in parts of Africa where climate drives both mosquito vector dynamics and parasite development rates. Hence, skilful seasonal climate forecasts may provide early warning of changes of risk in epidemic-prone regions. Here we discuss the development of a system to forecast probabilities of anomalously high and low malaria incidence with dynamically based, seasonal-timescale, multi-model ensemble predictions of climate, using leading global coupled ocean–atmosphere climate models developed in Europe. This forecast system is successfully applied to the prediction of malaria risk in Botswana, where links between malaria and climate variability are well established, adding up to four months lead time over malaria warnings issued with observed precipitation and having a comparably high level of probabilistic prediction skill. In years in which the forecast probability distribution is different from that of climatology, malaria decision-makers can use this information for improved resource allocation.
Defining and predicting heat waves in Bangladesh
Creators: name: Nissan, Hannah J.
name: Burkart, Katrin
name: Coughlan De Perez, Erin R.
name: Van Aalst, Maarten K.
name: Mason, Simon J.
Publisher: name: Columbia University
Year: 2019
Subjects: Heat waves (Meteorology)
Emergency management--Government policy
Long-range weather forecasting
Climatic changes--Forecasting

description: This paper proposes a heat-wave definition for Bangladesh that could be used to trigger preparedness measures in a heat early warning system (HEWS) and explores the climate mechanisms associated with heat waves. A HEWS requires a definition of heat waves that is both related to human health outcomes and forecastable. No such definition has been developed for Bangladesh. Using a generalized additive regression model, a heat-wave definition is proposed that requires elevated minimum and maximum daily temperatures over the 95th percentile for 3 consecutive days, confirming the importance of nighttime conditions for health impacts. By this definition, death rates increase by about 20% during heat waves; this result can be used as an argument for public-health interventions to prevent heat-related deaths. Furthermore, predictability of these heat waves exists from weather to seasonal time scales, offering opportunities for a range of preparedness measures. Heat waves are associated with an absence of normal premonsoonal rainfall brought about by anomalously strong low-level westerly winds and weak southerlies, detectable up to approximately 10 days in advance. This circulation pattern occurs over a background of drier-than-normal conditions, with below-average soil moisture and precipitation throughout the heat-wave season from April to June. Low soil moisture increases the odds of heat-wave occurrence for 10–30 days, indicating that subseasonal forecasts of heat-wave risk may be possible by monitoring soil-moisture conditions.
title: Ύπαρξη λύσης μερικών διαφορικών εξισώσεων σε χώρους Sobolev
Creators: name: Σιδηρόπουλος Νικόλαος Ε.
Publisher: name: Technical University of Crete
Year: 2012

description: 1. Ανασκόπηση βασικής θεωρίας -- 2. Μελέτη της ύπαρξης και μοναδικότητας λύσης ψευδογραμμικού συστήματος -- 3. Ύπαρξη λύσεων σε αόριστο ένα ελλειπτικό πρόβλημα τύπου p-q Laplacian  -- 4. Ελλειπτικά προβλήματα με την p(x)-Laplacian και ανταγωνιστικές μη-γραμμικότητες
Tolman-Ehrenfest's criterion of thermal equilibrium extended to conformally static spacetimes
Creators: name: Faraoni, Valerio
name: Vanderwee, Robert
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: With insight from examples and physical arguments, the Tolman-Ehrenfest criterion of thermal equilibrium for test fluids in static spacetimes is extended to local thermal equilibrium in conformally static geometries. The temperature of the conformally rescaled fluid scales with the inverse of the conformal factor, reproducing the evolution of the cosmic microwave background in Friedmann universes, the Hawking temperature of the Sultana-Dyer cosmological black hole, and a heuristic argument by Dicke.
description: Section on cosmological black holes added, bibliography expanded. Matches the version accepted in Phys. Rev. D
title: Η μέθοδος collocation για παραβολικές μερικές διαφορικές εξισώσεις με ασυνεχή συντελεστή διάχυσης
Creators: name: Παπαδομανωλάκη Μαρία Γ.
Publisher: name: Technical University of Crete
Year: 2012

description: 1. P-cyclic SOR για προβλήματα συνοριακών τιμών με περιοδικές συνοριακές συνθήκες -- 2. Γλοιώματα - μαθηματικό μοντέλο Swanson -- 3. Μέθοδος immersed interface πεπερασμένες διαφορές για το μοντέλο διάχυσης καρκινικών όγκων στον εγκέφαλο με ασυνεχή σταθερά διάχυσης -- 4. Hermite collocation μέθοδος για το μαθηματικό μοντέλο διάχυσης καρκινικών όγκων στον εγκέφαλο με ετερογενή σταθερά διάχυσης
Gaussian Processes for Nonlinear Signal Processing
Creators: name: Pérez-Cruz, Fernando
name: Van Vaerenbergh, Steven
name: Murillo-Fuentes, Juan José
name: Lázaro-Gredilla, Miguel
name: Santamaria, Ignacio
Publisher: name: arXiv
Year: 2013
Subjects: subject: Machine Learning (cs.LG)
subject: Information Theory (cs.IT)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Gaussian processes (GPs) are versatile tools that have been successfully employed to solve nonlinear estimation problems in machine learning, but that are rarely used in signal processing. In this tutorial, we present GPs for regression as a natural nonlinear extension to optimal Wiener filtering. After establishing their basic formulation, we discuss several important aspects and extensions, including recursive and adaptive algorithms for dealing with non-stationarity, low-complexity solutions, non-Gaussian noise models and classification scenarios. Furthermore, we provide a selection of relevant applications to wireless digital communications.
Trees of manifolds as boundaries of spaces and groups
Creators: name: Swiatkowski, Jacek
Publisher: name: arXiv
Year: 2013
Subjects: subject: Group Theory (math.GR)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 20F67, 20F65, 57M07

description: We show that trees of manifolds, the topological spaces introduced by Jakobsche, appear as boundaries at infinity of various spaces and groups. In particular, they appear as Gromov boundaries of some hyperbolic groups, of arbitrary dimension, obtained by the procedure of strict hyperbolization. We also recognize these spaces as boundaries of arbitrary Coxeter groups with manifold nerves, and as Gromov boundaries of the fundamental groups of singular spaces obtained from some finite volume hyperbolic manifolds by cutting off their cusps and collapsing the resulting boundary tori to points.
description: 23 pages
Numerical study of the Schwinger effect in axion inflation
Creators: name: Cado, Yann
name: Quirós, Mariano
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Previous studies demonstrate that the inflaton, when coupled to the hypercharge Chern-Simons density, can source an explosive production of helical hypermagnetic fields. Then, in the absence of fermion production, those fields have the capability of preheating the Universe after inflation and triggering a successful baryogenesis mechanism at the electroweak phase transition. In the presence of fermion production however, we expect a strong damping of the gauge fields production from the fermion backreaction, a phenomenon called Schwinger effect, thus jeopardizing their original capabilities. Using numerical methods we study the backreaction on the generated gauge fields and revisit the processes of gauge preheating and baryogenesis in the presence of the Schwinger effect. We have found that gauge preheating is very unlikely, while still having a sizable window in the parameter space to achieve the baryon asymmetry of the Universe at the electroweak phase transition.
description: fit the Physical Review D version, 30 pages, 8 figures
Pavlos Tzermias. Für eine Hellenistik mit Zukunft. Plädoyer für die Überwindung der Krise des Humanismus
Creators: name: Werner, Jürgen
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Pavlos Tzermias. Für eine Hellenistik mit Zukunft. Plädoyer für die Überwindung der Krise des Humanismus. Universitätsverlag Freiburg (Schweiz) 1998, 237 S., (ISBN 3-7278-1153-6).
description: Forum Classicum, Nr. 2 (2003): Forum Classicum
title: Μελέτη γεωμετρικών ιδιοτήτων χώρων Banach
Creators: name: Παυλάκος Περικλής Δ.
Publisher: name: Technical University of Crete
Year: 2013

description: Κεφ. 1: Στοιχεία από τη θεωρία χώρων Banach -- Κεφ. 2: Radon-Nikodym, Krein-Milman και συναφείς ιδιότητες -- Κεφ. 3: Κάθε non-dentable υποσύνολο του C(ωωk) περιέχει ένα κλειστό κυρτό υποσύνολο L τέτοιο ώστε το L έχει την PCP και όχι την RNP. Συνεπώς η RNP και η KMP είναι ισοδύναμες ιδιότητες στα υποσύνολα των χώρων Banach C(ωωk) -- Κεφ. 4: Η RNP και η KMP είναι ισοδύναμες ιδιότητες στα πηλίκα χώρων Banach με unconditional shrinking F.D.D. -- Κεφ. 5: Παράδειγμα non-dentable υποσυνόλου στα υποσύνολα του οποίου η RNP και η PCP είναι ισοδύναμες ιδιότητες
Multi-model sub-seasonal forecasts of Spring cold spells: potential value for the hazelnut agribusiness
Creators: name: Materia, Stefano
name: Muñoz, Ángel G.
name: Álvarez-Castro, Carmen
name: Mason, Simon J.
name: Vitart, Frederic
name: Gualdi, Silvio
Publisher: name: Columbia University
Year: 2020
Subjects: Long-range weather forecasting
Statistical weather forecasting--Methodology
Climatic changes--Models
Agriculture
Hazelnut industry

description: Producing probabilistic subseasonal forecasts of extreme events up to six weeks in advance is crucial for many economic sectors. In agribusiness, this time scale is particularly critical because it allows for mitigation strategies to be adopted for counteracting weather hazards and taking advantage of opportunities. For example, spring frosts are detrimental for many nut trees, resulting in dramatic losses at harvest time. To explore subseasonal forecast quality in boreal spring, identified as one of the most sensitive times of the year by agribusiness end users, we build a multisystem ensemble using four models involved in the Subseasonal to Seasonal Prediction project (S2S). Two-meter temperature forecasts are used to analyze cold spell predictions in the coastal Black Sea region, an area that is a global leader in the production of hazelnuts. When analyzed at the global scale, the multisystem ensemble probabilistic forecasts for near-surface temperature are better than climatological values for several regions, especially the tropics, even many weeks in advance; however, in the coastal Black Sea, skill is low after the second forecast week. When cold spells are predicted instead of near-surface temperatures, skill improves for the region, and the forecasts prove to contain potentially useful information to stakeholders willing to put mitigation plans into effect. Using a cost–loss model approach for the first time in this context, we show that there is added value of having such a forecast system instead of a business-as-usual strategy, not only for predictions released 1–2 weeks ahead of the extreme event, but also at longer lead times.
Bayesian refinement of covariant energy density functionals
Creators: name: Salinas, Marc
name: Piekarewicz, J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The last five years have seen remarkable progress in our quest to determine the equation of state of neutron rich matter. Recent advances across the theoretical, experimental, and observational landscape have been incorporated in a Bayesian framework to refine existing covariant energy density functionals previously calibrated by the properties of finite nuclei. In particular, constraints on the maximum neutron star mass from pulsar timing, on stellar radii from the NICER mission, on tidal deformabilities from the LIGO-Virgo collaboration, and on the dynamics of pure neutron matter as predicted from chiral effective field theories, have resulted in significant refinements to the models, particularly to those predicting a stiff symmetry energy. Still, even after these improvements, we find challenging to reproduce simultaneously the neutron skin thickness of both ${}^{208}$Pb and ${}^{48}$Ca recently reported by the PREX/CREX collaboration.
description: 16 pages, 7 Figures, 3 Tables
Trees of metric compacta and trees of manifolds
Creators: name: Swiatkowski, Jacek
Publisher: name: arXiv
Year: 2013
Subjects: subject: Geometric Topology (math.GT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F65, 57M07, 54D80

description: We present a construction, called the limit of a tree system of spaces (or, less formally, a tree of spaces). The construction is designed to produce compact metric spaces that resemble fractals, out of more regular spaces, such as closed manifolds, compact polyhedra, compact Menger manifolds, etc. Such spaces are potential candidates to be homeomorphic to ideal boundaries of infinite groups. A very special case of this construction, trees of manifolds (known also as Jakobsche spaces), has been studied in the literature. We present here a different approach, much more general, and, as we believe, much more convenient for establishing various basic properties of the resulting spaces, in a more general setting. Already in the case of trees of manifolds, using this approach we clarify, correct and extend so far known results and properties.
description: 45 pages
A criterion for good reduction of Drinfeld modules and Anderson motives in terms of local shtukas
Creators: name: Hartl, Urs
name: Hüsken, Simon
Publisher: name: arXiv
Year: 2013
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11G09, (14L05)

description: For an Anderson A-motive over a discretely valued field whose residue field has A-characteristic ε, we prove a criterion for good reduction in terms of its associated local shtuka at ε. This yields a criterion for good reduction of Drinfeld modules. Our criterion is the function-field analog of Grothendieck's and de Jong's criterion for good reduction of an abelian variety over a discretely valued field with residue characteristic p in terms of its associated p-divisible group.
description: 15 pages
title: The use of nano-particles for the development of enhanced gas barrier polymeric coatings
Creators: name: Χουδαλάκης Γεώργιος Α.
Publisher: name: Technical University of Crete
Year: 2013

description:  Nanocomposites -- 2. Mass transport principles -- 3. Permeability models -- 4. Transport coefficients and free volume -- 5. Measurement of free volume -- 6. Laponite nanocomposites -- 7. Bentonite nanocomposites -- 8. Hectorite nanocomposites -- 9. Organo-modified montmorillonite
title: Αριθμητικές μέθοδοι τύπου χαλάρωσης για προβλήματα μεταφοράς φερτών
Creators: name: Παπόγλου Ιωάννης Κ
Publisher: name: Technical University of Crete
Year: 2006

description:  Εισαγωγή -- 2. Περιγραφή του μαθηματικού μοντέλου -- 3. Αριθμητικά σχήματα -- 4. Αριθμητικά αποτελέσματα σε μια διάσταση -- 5. Το μαθηματικό μοντέλο και το σχήμα χαλάρωσης σε δύο διαστάσεις -- 6. Αριθμητικά αποτελέσματα σε δύο διαστάσεις
Estimation of turbulent proton and electron heating rates via Landau damping constrained by Parker Solar Probe observations
Creators: name: Shankarappa, Niranjana
name: Klein, Kristopher G.
name: Martinović, Mihailo M
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: The heating of ions and electrons due to turbulent dissipation plays a crucial role in the thermodynamics of the solar wind and other plasma environments. Using magnetic field and thermal plasma observations from the first two perihelia of the Parker Solar Probe (PSP), we model the relative heating rates as a function of radial distance, magnetic spectra, and plasma conditions, enabling us to better characterize the thermodynamics of the inner heliosphere. We employ the Howes et al. 2008 steady-state cascade model, which considers the behavior of turbulent, low-frequency, wavevector-anisotropic, critically balanced Alfvénic fluctuations that dissipate via Landau damping to determine proton-to-electron heating rates $Q_p/Q_e$. We distinguish ion-cyclotron frequency circularly polarized waves from low-frequency turbulence and constrain the cascade model using spectra constructed from the latter. We find that the model accurately describes the observed energy spectrum from over 39.4 percent of the intervals from Encounters 1 and 2, indicating the possibility for Landau damping to heat the young solar wind. The ability of the model to describe the observed turbulent spectra increases with the ratio of thermal-to-magnetic pressure, $β_p$, indicating that the model contains the necessary physics at higher $β_p$. We estimate high magnitudes for the Kolmogorov constant which is inversely proportional to the non-linear energy cascade rate. We verify the expected strong dependency of $Q_p/Q_e$ on $β_p$ and the consistency of the critical balance assumption.
Pschyrembel. Klinisches Wörterbuch, 259., neubearbeitete Auflage
Creators: name: Werner, Jürgen
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Pschyrembel. Klinisches Wörterbuch, 259., neubearbeitete Auflage. 1842 S. Walter de Gruyter, Berlin, New York 2002, (ISBN 3-11-016522-8).
description: Forum Classicum, Nr. 3 (2003): Forum Classicum
A mechanism for detecting normally hyperbolic invariant tori in differential equations
Creators: name: Pereira, Pedro C. C. R.
name: Novaes, Douglas D.
name: Cândido, Murilo R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 34C23, 34C29, 34C45

description: Determining the existence of compact invariant manifolds is a central quest in the qualitative theory of differential equations. Singularities, periodic solutions, and invariant tori are examples of such invariant manifolds. A classical and useful result from the averaging theory relates the existence of isolated periodic solutions of non-autonomous periodic differential equations, given in a specific standard form, with the existence of simple singularities of the so-called guiding system, which is an autonomous differential equation given in terms of the first non-vanishing higher order averaged function. In this paper, we provide an analogous result for the existence of invariant tori. Namely, we show that a non-autonomous periodic differential equation, given in the standard form, has a normally hyperbolic invariant torus in the extended phase space provided that the guiding system has a hyperbolic limit cycle. We apply this result to show the existence of normally hyperbolic invariant tori in a family of jerk differential equations.
Field theory of the quantum Hall nematic transition
Creators: name: Maciejko, J.
name: Hsu, B.
name: Kivelson, S. A.
name: Park, YeJe
name: Sondhi, S. L.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The topological physics of quantum Hall states is efficiently encoded in purely topological quantum field theories of the Chern-Simons type. The reliable inclusion of low-energy dynamical properties in a continuum description however typically requires proximity to a quantum critical point. We construct a field theory that describes the quantum transition from an isotropic to a nematic Laughlin liquid. The soft mode associated with this transition approached from the isotropic side is identified as the familiar intra-Landau level Girvin-MacDonald-Platzman mode. We obtain z=2 dynamic scaling at the critical point and a description of Goldstone and defect physics on the nematic side. Despite the very different physical motivation, our field theory is essentially identical to a recent "geometric" field theory for a Laughlin liquid proposed by Haldane.
description: 14 pages, 1 figure; for a short summary, see http://www.princeton.edu/~jmaciejk/fqhn/. v2: added references and comment on Hall viscosity (Sec. IV.B), v3: published version
On the use and misuse of climate change projections in international development
Creators: name: Nissan, Hannah J.
name: Goddard, Lisa M.
name: Coughlan De Perez, Erin
name: Furlow, John
name: Baethgen, Walter E.
name: Thomson, Madeleine C.
name: Mason, Simon J.
Publisher: name: Columbia University
Year: 2019
Subjects: Climatic changes
Climatic changes--Risk assessment
Climatic changes--Decision making
Climatic changes--Forecasting
Sustainable development

description: Climate resilience is increasingly prioritized by international development agencies and national governments. However, current approaches to informing communities of future climate risk are problematic. The predominant focus on end-of-century projections neglects more pressing development concerns, which relate to the management of shorter-term risks and climate variability, and constitutes a substantial opportunity cost for the limited financial and human resources available to tackle development challenges. When a long-term view genuinely is relevant to decisionmaking, much of the information available is not fit for purpose. Climate model projections are able to capture many aspects of the climate system and so can be relied upon to guide mitigation plans and broad adaptation strategies, but the use of these models to guide local, practical adaptation actions is unwarranted. Climate models are unable to represent future conditions at the degree of spatial, temporal, and probabilistic precision with which projections are often provided, which gives a false impression of confidence to users of climate change information. In this article, we outline these issues, review their history, and provide a set of practical steps for both the development and climate scientist communities to consider. Solutions to mobilize the best available science include a focus on decision-relevant timescales, an increased role for model evaluation and expert judgment and the integration of climate variability into climate change services
Understanding forecast verification statistics
Creators: name: Mason, Simon J.
Publisher: name: Columbia University
Year: 2008
Subjects: Climatic changes--Forecasting
Long-range weather forecasting
Statistical weather forecasting

description: Although there are numerous reasons for performing a verification analysis, there are usually two general questions that are of interest: are the forecasts good, and can we be confident that the estimate of forecast quality is not misleading? When calculating a verification score, it is not usually obvious how the score can answer either of these questions. Some procedures for attempting to answer the questions are reviewed, with particular focus on p-values and confidence intervals. P-values are shown to be rather unhelpful in answering either question, especially when applied to probabilistic verification scores, and confidence intervals are to be preferred. However, confidence intervals cannot reveal biases in the value of a score that arises from an inadequate experimental design for testing on truly out-of-sample observations. Some specific problems with cross validation are highlighted. Finally, in the interests of increasing the insight into forecast strengths and weaknesses and in pointing towards methods for improving forecast quality, a plea is made for a more discriminating selection of verification procedures than has been adopted to date.
Folding dynamics and its intermittency in turbulence
Creators: name: Qi, Yinghe
name: Meneveau, Charles
name: Voth, Greg
name: Ni, Rui
Publisher: name: arXiv
Year: 2023
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Fluid elements deform in turbulence by stretching and folding. In this work, by projecting the material deformation tensor onto the largest stretching direction, the dynamics of folding is depicted through the evolution of the material curvature. Results from direct numerical simulation (DNS) show that the curvature growth exhibits two regimes, first a linear stage dominated by folding fluid elements through a persistent velocity Hessian which then transitions to an exponential growth driven by the stretching of already strongly bent fluid elements. This transition leads to strong curvature intermittency at later stages, which can be explained by a proposed curvature-evolution model. The link between velocity Hessian to folding provides a new way to understand the crucial steps in energy cascade and mixing in turbulence beyond the classical linear description.
title: Η κατεδάφιση ως καταστροφή και ως νέα δημιουργία
Creators: name: Καρφη Χριστιανα
Publisher: name: Technical University of Crete
Year: 2015

description: Η παρούσα ερευνητική εργασία ασχολείται με την έννοια της κατεδάφισης ως ένας από τους πιο δυναμικούς μηχανισμούς μετασχηματισμού των πόλεων. Αρχικά, γίνεται μία αναφορά σε κάποια δίπολα με έννοιες χρήσιμες για την κατανόηση του φαινομένου της κατεδάφισης. Στη συνέχεια, μελετάται το θεωρητικό πλαίσιο των δύο αντικρουόμενων απόψεων κατά και υπέρ της κατεδάφισης. Ενώ, τέλος, παρατίθενται τέσσερα παραδείγματα προμελετημένων κατεδαφίσεων, με σκοπό να αναζητηθούν αίτια και συνέπειες και να εξεταστεί αν εν τέλει επρόκειτο για καταστροφές ή αν διαμόρφωσαν τις προϋποθέσεις για νέες δημιουργίες.
title: Η πόλη σε νέα όρια. Η προσωρινή κατοίκηση ως εργαλείο επαναπροσδιορισμού της αστικής μνήμης της Δραπετσώνας
Creators: name: Μαλαμα Ελευθερια
name: Παυλακη Ευαγγελια
Publisher: name: Technical University of Crete
Year: 2015

description: Η εργασία αυτή εχει ως αντικείμενο τη μελέτη, ανάλυση και πρόταση στρατηγηκής για την αναδιαμόρφωση κομβικών σημείων και δικτύων σε περιοχή της Δραπετσώνας του Πειραιά καθώς και την πρόταση δημιουργίας συστήματος προσωρινής κατοίκησης στην περιοχή της Ηετιώνειας πύλης.
Bob Dylan
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2019
Subjects: Popular culture

description: Fass and Jake Holmes discuss art, Leon Uris, satire, drugs, and the effect of bad reviews on the profitability of musicals. "Snoot Full of Snow," by Allen & Grier and "The Ballad of a Thin Man" by Bob Dylan play.
Annihilator of Top Local Cohomology and Lynch's Conjecture
Creators: name: Fathi, Ali
Publisher: name: arXiv
Year: 2022
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13D45, 14B15, 13E05

description: Let $R$ be a commutative Noetherian ring, $\mathfrak a$ a proper ideal of $R$ and $N$ a non-zero finitely generated $R$-module with $N\neq \mathfrak a N$. Let $d$ (respectively $c$) be the smallest (respectively greatest) non-negative integer $i$ such that the local cohomology $\operatorname{H}^i_{\mathfrak a}(N)$ is non-zero. In this paper, we provide sharp bounds under inclusion for the annihilators of the local cohomology modules $\operatorname{H}^d_{\mathfrak a}(N)$, $\operatorname{H}^c_{\mathfrak a}(N)$ and these annihilators are computed in certain cases. Also, we construct a counterexample to Lynch's conjecture.
description: All comments are welcome
Collective Quantum Dot Inversion and Amplification of Photon and Phonon Waves
Creators: name: Das, Sumanta
name: Macovei, Mihai
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The possibility of steady-state population inversion in a small sample of strongly driven two-level emitters like quantum dots (QDs) in micro-cavities, and its utilization towards amplification of light and acoustic waves is investigated theoretically. We find that inversion and absorption spectrum of photons, and phonons crucially depend on the interplay between the intrinsic vacuum and phonon environments. The absorption profiles of photons and phonons show marked novel features like gain instead of transparency and absorption reversed to gain, respectively. Furthermore, we report collectivity induced substantial enhancement of inversion and pronounced gain in the photon, and phonon absorption spectrum for a wavelength size QD ensemble.
description: 5 pages, 3 figures
The 1997-98 summer rainfall season in southern Africa. Part II: model simulations and coupled model forecasts
Creators: name: Lyon, Bradfield
name: Mason, Simon J.
Publisher: name: Columbia University
Year: 2009
Subjects: Rain and rainfall--Analysis
Climatic changes--Forecasting
Climatic changes--Models

description: This is the second of a two-part investigation of rainfall in southern Africa during the strong El Nino of 1997/98. In Part I it was shown that widespread drought in southern Africa, typical of past El Nino events occurring between 1950 and 2000, generally failed to materialize during the 1997/98 El Nino, most notably during January–March (JFM) 1998. Here output from three atmospheric general circulation models (AGCMs) forced with observed sea surface temperatures (SSTs) and seasonal forecasts from three coupled models are examined to see to what extent conditions in JFM 1998 could have potentially been anticipated. All three AGCMs generated widespread drought conditions across southern Africa, similar to those during past El Nino events, and did a generally poor job in generating the observed rainfall and atmospheric circulation anomaly patterns, particularly over the eastern and southern Indian Ocean. In contrast, two of the three coupled models showed a higher probability of wetter conditions in JFM 1998 than for past El Nino events, with an enhanced moisture flux from the Indian Ocean, as was observed. However, neither the AGCMs nor the coupled models generated anomalous stationary wave patterns consistent with observations over the South Atlantic and Pacific. The failure of any of the models to reproduce an enhanced Angola low (favoring rainfall) associated with an anomalous wave train in this region suggests that the coupled models that did indicate wetter conditions in JFM 1998 compared to previous El Nino episodes may have done so, at least partially, for the wrong reasons. The general inability of the climate models used in this study to generate key features of the seasonal climate over southern Africa in JFM 1998 suggests that internal atmospheric variability contributed to the observed rainfall and circulation patterns that year. With the caveat that current climate models may not properly respond to SST boundary forcing important to simulating southern Africa climate, this study finds that the JFM 1998 rainfall in southern Africa may have been largely unpredictable on seasonal time scales.
System testing in scientific numerical software frameworks using the example of DUNE
Creators: name: Kempf, Dominic
name: Koch, Timo
Publisher: name: Archive of Numerical Software
Year: 2017
Subjects: subject: numerical software frameworks, system testing, testing, dune
subject: 68 Computer Science

description: We present dune-testtools, a collection of tools for system testing in scientific soft-
ware using the example of the Distributed Unified Numerics Environment (Dune). Testing is
acknowledged as indispensible support for scientific software development and assurance of
software quality to produce trustworthy simulation results. Most of the time, testing in soft-
ware frameworks developed at research facilities is restricted to either unit testing or simple
benchmark programs. However, in a modern numerical software framework, the number of pos-
sible feature combinations constituting a program is vast. Only system testing, meaning testing
within a possible end user environment also emulating variability, can assess software quality
and reproducibility of numerical results. We provide an easy-to-use interface taking workload off
developers and administrators in open-source scientific numerical software framework projects.
In our approach, the large number of possible combinations is reduced using the scientific expert
knowledge of developers to identify the practically relevant combinations. Our approach to
system testing is designed to be integrated in the workflow of a research software developing
scientist.
description: Archive of Numerical Software, Vol 5, No 1 (2017)