Dataset for 'In situ theranostic platform uniting highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D'
Creators: name: Hofmann, Ulrich G.
name: Buchholz, Oliver
name: Bär, Sebastian
name: Franke, Jochen
name: Sajjamark, Kulthisa
name: Wei, Huimin
name: Behrends, André
name: Münkel, Christian
name: Grüttner, Cordula
name: Levan, Pierre
name: von Elverfeldt, Dominik
name: Graeser, Matthias
name: Buzug, Thorsten
Publisher: name: figshare
Year: 2023
Subjects: Medical physics
Other biomedical and clinical sciences not elsewhere classified
Biomedical imaging
Biomaterials
Biomedical instrumentation
Micro- and nanosystems
Nanomaterials
Experimental methods in fluid flow, heat and mass transfer

description: This file contains information about the file names and locations for the data used to build figurtes in the manuscript: In situ theranostic platform uniting highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D <br> # figure 1 - general description # MPI guided MFH. Visualization of the gradient field distribution in space resulting from spatially varying magnetic fields. Only SPION located in the region with the vanishing magnetic strength (field free region, FFR) can interact (imaging, heating, etc.) with additional magnetic influences. FLIR-camera characterization of global heating (selection field OFF) and spatial distribution in a 3D phantom of SPION samples within the FOT distributed over a grid of 16x16mm (in y- and z- direction) surrounding the center of the MPI-MFH platform (x =0). <br> # figure 2 - Determination of field of therapy (FOT) # MFH insert is moved in X-direction equipped with 9 SPION samples (synomag-D-70, 140µl, 10mg/(Fe)/ml). global MFH is applied (P = 600W, two heating cycles 25s) # figure 3 - Determination of MFH-FFR # driving through the MFH insert in every direction around the center with a robot controlled sample holder equipped with SPION sample (synomag-D-70, 27µl, 10mg/(Fe)/ml). local MFH is applied to the MPI-MFH platoforms' center (fixed FFP (x,y,z direction of 1.25 T/m , 1.25 T/m , 2.5 T/m respectively), P = 300W, one heating cycle 30 s) # figure 4- Agarose MFH # Thermal camera monitored extent of temperature change in a SPION-filled petri dish subjected to localized and global MFH. # Localized MFH: # figure 5A-E - comparison of different SPION samples at different concentrations samples were subjected to MFH: P = 600 W, selection field gradient = 1 T/m, 1 T/m, 2 T/m, (x, y, z), 1 heating cycle of duration = 10 s <br> # figure 5F - MPS measurements # folder "MPS_Data" contains the raw MPS measurements (pure devices, drive field = 25mT, excitation frequency = 25kHz) from the different SPION samples (50µl) at their respective stock concentration (see figure 10 (table SPION samples)) <br> # figure 6a - targetted heating in punctiform SPION samples samples were successively subjected to MFH: P = 600 W, selection field gradient = 1 T/m, 1 T/m, 2 T/m, (x, y, z), 1 heating cycle of duration = 10 s <br> # figure 6b - targetted heating in agarose # folder "targetted heating"; subfolder "agarose" MFH targeting in a continuous agarose-SPION suspension. The MFH target describes a circle through the agarose-SPION hydrogel. Spatio-temporal distribution of the maximal temperature on the agarose surface every 3.3 s corroborates a circular MFH trajectory. two lines were drawn through the center of the thermal camera recordings representing the y- and z planes within the MPI-MFH platform. The maxima at distinct timepoints during MFH of those axes were plotted. # thermal camera recordings: subfolder "thermal camera readout" Z_1(-34).csv represents the maximal temperature values of the z- plane Y_1(-34).csv represents the maximal temperature values of the y- plane # pixel size = 0.29 mm # Figure 7 - Interleaved MPI-MFH1 # Three SPION samples at equidistant positions within the MPI-MFH platform (x, z = 0 mm; y = -8, 0, 8 mm form center) were subjected to alternating MPI-MFH sequences. # By adjusting the MFH-FFR, the SPION sample positioned at y= -8 mm, was targeted by MFH while MPI images were acquired of all samples. # The MPI images used for MPI-based thermometry are stored in folder "MPI meausurements" subfolder "E31" (name of measurement) subsubfolder "19" (name of reconstruction) # The multi-contrast reconstruction results are stored in the folder "MPI multi-contrast results". "multi_color_spot1.mat is the MPI signal over time for the SPION sample at y= -8 mm "multi_color_spot2.mat is the MPI signal over time for the SPION sample at y= 0 mm "multi_color_spot3.mat is the MPI signal over time for the SPION sample at y= +8 mm <br> # thermal camera data of SPION samples is stored in the folder "thermal camera readout" Rec138_left.txt is the temperature profile of the SPION sample at y= -8 mm Rec138_mid.txt is the temperature profile of the SPION sample at y= 0 mm Rec138_right.txt is the temperature profile of the SPION sample at y= +8 mm <br> # Figure 8 - Interleaved MPI-MFH2 # Three SPION samples at equidistant positions within the MPI-MFH platform (x, z = 0 mm; y = -8, 0, 8 mm form center) were subjected to alternating MPI-MFH sequences. # By adjusting the MFH-FFR, the SPION samples were targeted successively while the temperature profile was monitored with a thermal camera. <br> # The MPI images used for MPI-based thermometry are stored in folder "MPI meausurements" subfolder "E24" (name of measurement) &amp; subsubfolder "3" (name of reconstruction) # The multi-contrast reconstruction results are stored in the folder "MPI multi-contrast results". E24_values_left.mat &lt;- MPI signal over time for the SPION sample at y= -8 mm E24_values_center.mat &lt;- MPI signal over time for the SPION sample at y= 0 mm E24_values_right.mat &lt;- MPI signal over time for the SPION sample at y= +8 mm <br> # thermal camera data of SPION samples is stored in the folder "thermal camera readout" Rec139_left.txt is the temperature profile of the SPION sample at y= -8 mm Rec139_center.txt is the temperature profile of the SPION sample at y= 0 mm Rec139_right.txt is the temperature profile of the SPION sample at y= +8 mm <br> # figure 9 - dynamic phantom # Effect of MFH in a flow phantom. A flow system connected to a tube filled with SPIONs was placed inside the MPI bore to mimic blood circulation and investigate the effect of circulation velocity on heating efficiency. The circulation phantom was targeted with interleaved MPI and MFH cycles successively heating and imaging the circulating SPION. # folder "dynamic_phantom" # Thermal camera measurements at different flow velocities: <br> Rec261_center.txt &lt;- 0.0 ml/min Rec264_center.txt &lt;- 0.2 ml/min Rec265_center.txt &lt;- 0.3 ml/min Rec266_center.txt &lt;- 0.4 ml/min Rec267_center.txt &lt;- 0.5 ml/min Rec268_center.txt &lt;- 0.6 ml/min Rec269_center.txt &lt;- 0.7 ml/min Rec270_center.txt &lt;- 0.8 ml/min Rec271_center.txt &lt;- 0.9 ml/min Rec272_center.txt &lt;- 1.0 ml/min Rec273_center.txt &lt;- 1.1 ml/min Rec274_center.txt &lt;- 1.2 ml/min Rec275_center.txt &lt;- 1.3 ml/min Rec276_center.txt &lt;- 1.4 ml/min Rec277_center.txt &lt;- 1.5 ml/min Rec278_center.txt &lt;- 1.6 ml/min Rec280_center.txt &lt;- 1.8 ml/min Rec279_center.txt &lt;- 2.0 ml/min Rec281_center.txt &lt;- 2.25 ml/min Rec285_center.txt &lt;- 6.0 ml/min Rec286_center.txt &lt;- 7.5 ml/min Rec287_center.txt &lt;- 10.0 ml/min Rec288_center.txt &lt;- 12.5 ml/min <br> # Acquired MPI images were used to reconstruct temperature progression during MFH using the MPI-based multicolor method on the basis of thermal camera measurements. # Folder: "MPI measurements" # MPI measurements used for temperature reconstruction (measurement folder/reconstruction folder): 387/20 &lt;- 0.0 ml/min 388/20 &lt;- 0.2 ml/min 389/16 &lt;- 0.3 ml/min 390/12 &lt;- 0.4 ml/min 392/11 &lt;- 0.5 ml/min <br> # MPI- based multi-contrast results in folder "multi_contrast_results" <br> # figure 10 - table comparison tracer # stored in folder: "tracer comparison/figures/table_tracers" <br>