cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
D2.4 Stakeholder-informed research questions
Creators: name: Briers, Stephanie
name: Vienni Baptista, Bianca
Publisher: name: Zenodo
Year: 2024

description: The DIAMOND project undertakes a transdisciplinary (TD) approach to update, expand, open, and develop scenarios for six Integrated Assessment Models, with the aim of addressing net zero emissions and sustainable development. WP2: Codesign leads this TD approach, which is broken down into three multi-stage phases: i) mutual understanding; ii) knowledge co-production; and iii) model co-ownership. Deliverable D2.4 presents the results of the first two out of three stages in “Phase 1: Toward Mutual Understanding”, which is based on the concept of “joint-problem framing” indicated by the TD scientific literature as the initial step within a fruitful stakeholder engagement plan. The aim and output of this phase is a set of stakeholder-informed research questions, which are co-created in three stages. Stage 1 is a familiarisation stage, aiming to find common ground among DIAMOND partners and their work. Stage 2 focuses on reaching mutual understanding of the goals and aims of the transdisciplinary approach to be implemented by DIAMOND partners. This Deliverable, D2.4, presents these two stages and concludes in actions falling under three themes. These themes include: (a) strengthening internal and external communities of practice, (b) focusing codesign activities, and (c) improving the effectiveness of stakeholder engagement. These outcomes will be picked up on in Stage 3, which commenced in January 2024 and will conclude Phase 1 of DIAMOND’s codesign process with the output of a final set of stakeholder-informed research questions, to be presented in Deliverable D2.5 (update of this deliverable).
social reproduction of labour and macro theory
Creators: name: Setterfield, Mark
Publisher: name: PSL Quarterly Review
Year: 2024
Subjects: Social reproduction of labour
human capacities
feminist macroeconomics
first Harrod problem
distribution and growth
B54
E11
E12
O41

description: The thesis advanced in this paper is that like class and technical change, gender and the social reproduction of labour routinely shape demand formation and/or the supply side of the economy — and as such, reference to the gendered social reproduction of labour should be more routinely incorporated into macro-theoretic analysis. The argument is developed with reference to two familiar issues in heterodox macrodynamics: reconciliation of the equilibrium and natural rates of growth; and the relationship between distribution and growth. Using an existing feminist macro model as a point of departure, it is shown that proper account of the social reproduction of labour and its gendered character creates important new insights into both the processes by which the equilibrium and natural rates of growth might be equalized, and the underlying character (wage- versus profit-led) of the relationship between distribution and growth.
description: PSL Quarterly Review, V. 77 N. 310 (2024): September
“CRYPTA MANENT”. I primi Cristiani e le Catacombe dell’antica Roma. Ipotesi preliminare per un percorso espositivo archeologico ad alta tecnologia, collegato a stream di dataset aperti [LOD], e installata in un moderno museo itinerante
Creators: name: Laquidara, Giuseppe
name: Boém, Marika Mazzi
Publisher: name: figshare
Year: 2013
Subjects: subject: Art
subject: Education
subject: Archaeology
subject: History
subject: Performing Arts
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Computer Engineering
subject: Applied Computer Science

description: Crypta Manent ‘013 aims to create a hybrid virtual-reality, immersive, and scenographic exhibition-space/path, representing a Catacomb of the Ancient Rome, installed inside a modern, itinerant museum. The resulting environment is dynamically connected to big open dataset [LOD], specific for the archeological Built Heritage, enriched with correlated media resources, aiming to process them in quasi-real time, through urgent computation algorithms, and live reproducing different path and archeo-environment live. The resulting experience touches every sense and stimuli [visual, acoustic,tactile, olfactory, cognitive and learning], coming to the "immersive" experiment, since a so called "tech-capsule" is installed reproducing in stereoscopic, immersive performance a real underground walkway, assisted by wearable devices. The dynamics of data streams coming from the set of Big Open Data, leads up to the experience to “5 dimensions”.
Jesse W. Torgerson, The Chronographia of George the Synkellos and Theophanes.
Creators: name: Cecota, Błażej
Publisher: name: The Byzantine Review
Year: 2024
Subjects: Theophanes the Confessor
historiography
Byzantine history

description: Jesse W. Torgerson, The Chronographia of George the Synkellos and Theophanes. The Ends of Time in Ninth-Century Constantinople (Brill’s Series on the Early Middle Ages 28). Leiden – Boston: Brill 2022. xviii + 458 pp. – ISBN 978-90-04-50169-0
description: The Byzantine Review, Bd. 6 (2024)
Jean-Luc Fournet, The Rise of Coptic: Egyptian versus Greek in Late Antiquity
Creators: name: Richter, Siegfried G.
Publisher: name: The Byzantine Review
Year: 2024
Subjects: Coptic language
Greek language

description: Jean-Luc Fournet, The Rise of Coptic: Egyptian versus Greek in Late Antiquity (The Rostovtzeff Lectures). Princeton: Princeton University Press 2020. X, 206 pp. – ISBN 978-0-691-19834-7
description: The Byzantine Review, Bd. 6 (2024)
Structural change, social inclusion, and environmental sustainability: New perspectives and policies in economic development
Creators: name: Isabella, Fernando
name: Castillo, Jimena
name: Yajima, Giuliano Toshiro
Publisher: name: PSL Quarterly Review
Year: 2024
Subjects: structural change
social inclusion
environmental sustainability
economic development
O11
O44
Q01
E24
F63
P16

description: This special issue addresses the challenges of the international economy, focusing on structural change, social inclusion, and environmental sustainability. It brings together contributions from senior and young scholars, many from Latin America, to explore multidimensional issues like inequality, geopolitical tensions, financial instability, environmental crises, and technological asymmetries. The selected papers, initially presented at the 1st International Workshop on Structural Change, Social Inclusion, and Environmental Sustainability, provide diverse perspectives on topics such as economic policy for a fair transition, centre-periphery dynamics, and the intersection of gender, labour, and economic growth. These works aim to foster collaboration between experienced and emerging voices, enriching the conversation around economic development through pluralist approaches.
description: PSL Quarterly Review, V. 77 N. 310 (2024): September
Referential GBP based on CPI (2012e)
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: Referential GBP provides the inflator/deflator multiplier for standardizing UK pounds (rGBP, r£) (within the philosophy of referential currencies). It is based on the average annual CPI for Great Britain. (Also retrievable from Wiki of Science.)
optimized filter trap assay for detecting recombinant authentic tau fibrils
Creators: name: Balaj, Allison R.
name: Rothstein, Thomas L.
name: Kaku, Hiroaki
Publisher: name: Free Neuropathology
Year: 2024
Subjects: Truncated tau fibrils
Filter trap assay
Sarkosyl
Tauopathies
Protein aggregation

description: The development and optimization of the Filter Trap Assay (FTA) for the detection of authentic tau fibrils in vitro mark a pivotal advancement in the realm of tauopathy research, particularly by addressing the limitations of using polyanion-induced tau fibrils, which structurally differ from those isolated from tauopathy patients. Recently it has been shown that truncated tau fragment (297-391), also termed dGAE, can form authentic tau fibrils in the absence of polyanions. This study introduces a refined protocol that reliably detects authentic tau fibrils in a physiologically relevant framework, utilizing nitrocellulose membranes to achieve heightened sensitivity. Our investigation highlights the superior efficacy of sarkosyl, an anionic surfactant traditionally used to prepare protein lysates from brains and cultured neurons, in preserving the aggregated state of tau dGAE fibrils in vitro, underscoring its potential for further exploratory studies. By offering a user-friendly and economically feasible approach, this technique enables a broad range of laboratories to measure the presence of authentic tau fibrils. This methodological enhancement propels our understanding of tauopathies forward and bridges the gap between basic research and advanced structural analyses, enriching the scientific community's methodologies for studying neurodegenerative disorders.
description: Free Neuropathology, Bd. 5 (2024)
On Marx and accounting: An empirical study of the transformation of values into prices of production in the Brazilian contemporary economy, 2010-2022
Creators: name: Segura Moraes, Leonardo
name: De Azevedo, Raquel
Publisher: name: PSL Quarterly Review
Year: 2024
Subjects: Competition
Brazilian economy
Marx
Accounting
B51
E11
M41
P12

description: The purpose of this paper is to present some notes on the contemporary Brazilian economy between 2010 and 2022, translating items from the value added statement (VAS) and the balance sheet of a sample of 48 companies that make up the Bovespa Index (Ibovespa, in Portuguese) portfolio into Marxist economic theory.

The information was obtained from InvestSite (https://www.investsite.com.br/) and Economatica (https://economatica.com/) databases. In this sense, we observed some general trends and countertrends of real competition in the Brazilian economy, based on the empirical formulation of the concepts of constant capital, variable capital, surplus-value, turnover of capital, cost-price, price of production, rate of profit, and rate of surplus-value. In this way, we hope to contribute to a research agenda on the criteria for production and appropriation of surplus-value in Brazil, as well as to use the Marxian procedure of transformation of values into prices of production as a macroeconomic tool.
description: PSL Quarterly Review, V. 77 N. 310 (2024): September
Factors affecting self-medication practices among people living with type 2 diabetes in India - a Systematic Review
Creators: name: Puvvada, Rahul Krishna
name: Gupta, Sabrina
name: Youci Tang
name: Althubyani, Anwar Noor Y
name: Markandeya Jois
name: Higgs, Peter
name: M Ramesh
name: Jency Thomas
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Self-medication practices of type 2 diabetes in India include the use of both traditional and western medications. It is important to understand the factors influencing self-medication. A total of 3257 studies were screened and nine studies (six quantitative and three qualitative) were included. The Hawker tool and Joanna Briggs Institute Critical Appraisal tool were used to assess the quality of studies. The findings of the quantitative studies were descriptively analysed while thematic analysis was performed to identify key themes from the qualitative studies. The analysis indicated that participants had greater trust in traditional medications regardless of their socioeconomic and/or educational backgrounds as these were often recommended by friends and family members. Low cost, ease of availability and perceived lower side effects of traditional medications were some of the factors contributing to greater trust. It is suggested that ongoing management of type 2 diabetes requires stringent policies and regulations in the dispensing of traditional and western medications. Continual education to inform people on the use of self-medications and its possible adverse effects is also required.
An intact membrane is essential for small extracellular vesicle‐induced modulation of α‐synuclein fibrillization
Creators: name: Ugalde, Cathryn
name: Gordon, Shane
name: Shambrook, Mitch
name: Amirmohammad Nasiri Kenari
name: Coleman, Bradley M
name: Perugini, Matthew
name: Lawson, Victoria A
name: Finkelstein, David I
name: Hill, Andrew
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to as the synucleinopathies. Understanding the mechanisms of αsyn misfolding is an important area of interest given that αsyn misfolding contributes to disease pathogenesis. While many studies report the ability of synthetic lipid membranes to modulate αsyn folding, there is little data pertaining to the mechanism(s) of this interaction. αSyn has previously been shown to associate with small lipid vesicles released by cells called extracellular vesicles (EVs) and it is postulated these interactions may assist in the spreading of pathological forms of this protein. Together, this presents the need for robust characterisation studies on αsyn fibrillization using biologically-derived vesicles. In this study, we comprehensively characterised the ability of lipid-rich small extracellular vesicles (sEVs) to alter the misfolding of αsyn induced using the Protein Misfolding Cyclic Amplification (PMCA) assay. The biochemical and biophysical properties of misfolded αsyn were examined using a range of techniques including: Thioflavin T fluorescence, transmission electron microscopy, analytical centrifugation and western immunoblot coupled with protease resistance assays and soluble/insoluble fractionation. We show that sEVs cause an acceleration in αsyn fibrillization and provide comprehensive evidence that this results in an increase in the abundance of mature insoluble fibrillar species. In order to elucidate the relevance of the lipid membrane to this interaction, sEV lipid membranes were modified by treatment with methanol, or a combination of methanol and sarkosyl. These treatments altered the ultrastructure of the sEVs without changing the protein cargo. Critically, these modified sEVs had a reduced ability to influence αsyn fibrillization compared to untreated counterparts. This study reports the first comprehensive examination of αsyn:EV interactions and demonstrates that sEVs are powerful modulators of αsyn fibrillization, which is mediated by the sEV membrane. In doing so, this work provides strong evidence for a role of sEVs in contributing directly to αsyn misfolding in the synucleinopathy disorders.
title: Kreative Sondervermögensgestaltung: Die Kritik des Bundesrechnungshofs an der Zweckerweiterung des Sondervermögens Bundeswehr
Creators: name: Peltzer, Fabian
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2023
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
Bionic 3D printed corals.
Creators: name: Wangpraseurt, Daniel
name: You, Shangting
name: Azam, Farooq
name: Jacucci, Gianni
name: Gaidarenko, Olga
name: Hildebrand, Mark
name: Kühl, Michael
name: Smith, Alison G
name: Davey, Matthew P
name: Smith, Alyssa
name: Deheyn, Dimitri D
name: Chen, Shaochen
name: Vignolini, Silvia
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Corals have evolved as optimized photon augmentation systems, leading to space-efficient microalgal growth and outstanding photosynthetic quantum efficiencies. Light attenuation due to algal self-shading is a key limiting factor for the upscaling of microalgal cultivation. Coral-inspired light management systems could overcome this limitation and facilitate scalable bioenergy and bioproduct generation. Here, we develop 3D printed bionic corals capable of growing microalgae with high spatial cell densities of up to 109 cells mL-1. The hybrid photosynthetic biomaterials are produced with a 3D bioprinting platform which mimics morphological features of living coral tissue and the underlying skeleton with micron resolution, including their optical and mechanical properties. The programmable synthetic microenvironment thus allows for replicating both structural and functional traits of the coral-algal symbiosis. Our work defines a class of bionic materials that is capable of interacting with living organisms and can be exploited for applied coral reef research and photobioreactor design.
Psychometric Properties of the Chinese version of UPPS-P Impulsive Behavior Scale.
Creators: name: Zhang, Yingying
name: Qiu, Xian
name: Ren, Qihuan
name: Zhou, Zhirong
name: Zhou, Huijing
name: Du, Jiang
name: Voon, Valerie
name: Zhang, Chencheng
name: Liu, Wenjuan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: The present study aimed to assess the psychometric properties of a Chinese version of the UPPS-P Impulsive Behavior Scale. The associations between the UPPS-P scale and impulsivity choice, gender, smoking, and drinking status were also assessed. A total of 127 adults ranging from 21 to 65 years old participated in the study. Participants were administered with the Chinese version of the UPPS-P Impulsive Behavior Scale, Beck Depression Inventory II (BDI-II), and State-Trait Anxiety Inventory (STAI). Impulsivity choice tasks were also tested including the Delay Discounting Task (DDT), Balloon Analogue Risk Task (BART), and Beads Task (Beads). A new version of the UPPS-P Impulsive Behavior Scale was formed that includes 40 items. The scores of the UPPS-P Impulsive Behavior Scale demonstrated adequate internal consistency on five subscales but less sufficient structure validity in the present sample. In addition, positive urgency was negatively related to the Beads task; negative urgency and positive urgency were positively related to the DDT and BART. Moreover, positive and negative urgency were positively correlated with depression; all five subscales were positively correlated with anxiety; sensation seeking was higher in males than females and in alcohol drinkers than non-drinkers; and lack of premeditation and lack of perseverance were higher in nonsmokers than smokers. The present study supports the reliability but not the structure validity of the UPPS-P Impulsive Behavior Scale. The impulsivity personality trait assessed by the UPPS-P scale was associated with impulsivity choice, depression, anxiety, gender, and drinking and smoking status. Further studies should be conducted to explore the structure of impulsivity in the Chinese population.
Characteristics, service use and mortality of clusters of multimorbid patients in England: a population-based study.
Creators: name: Zhu, Yajing
name: Edwards, Duncan
name: Mant, Jonathan
name: Payne, Rupert A
name: Kiddle, Steven
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Pattern recognition
Validation
Chronic Conditions
Latent Class Analysis
Age Stratification
Multimorbidity Phenotype

description: BACKGROUND:Multimorbidity is associated with mortality and service use, with specific types of multimorbidity having differential effects. Additionally, multimorbidity is often negatively associated with participation in research cohorts. Therefore, we set out to identify clusters of multimorbidity patients and how they are differentially associated with mortality and service use across age groups in a population-representative sample. METHODS:Linked primary and secondary care electronic health records contributed by 382 general practices in England to the Clinical Practice Research Datalink (CPRD) were used. The study included a representative set of multimorbid adults (18 years old or more, N = 113,211) with two or more long-term conditions (a total of 38 conditions were included). A random set of 80% of the multimorbid patients (N = 90,571) were stratified by age groups and clustered using latent class analysis. Consistency between obtained multimorbidity phenotypes, classification quality and associations with demographic characteristics and primary outcomes (GP consultations, hospitalisations, regular medications and mortality) was validated in the remaining 20% of multimorbid patients (N = 22,640). RESULTS:We identified 20 patient clusters across four age strata. The clusters with the highest mortality comprised psychoactive substance and alcohol misuse (aged 18-64); coronary heart disease, depression and pain (aged 65-84); and coronary heart disease, heart failure and atrial fibrillation (aged 85+). The clusters with the highest service use coincided with those with the highest mortality for people aged over 65. For people aged 18-64, the cluster with the highest service use comprised depression, anxiety and pain. The majority of 85+-year-old multimorbid patients belonged to the cluster with the lowest service use and mortality for that age range. Pain featured in 13 clusters. CONCLUSIONS:This work has highlighted patterns of multimorbidity that have implications for health services. These include the importance of psychoactive substance and alcohol misuse in people under the age of 65, of co-morbid depression and coronary heart disease in people aged 65-84 and of cardiovascular disease in people aged 85+.
Studio iniziale per un quasi-MAB [quasi-Multi Authors Blog] denominato “RIW”, ~“RevolutionIstWebber”, fondato su criteri partecipativi e di behavioural cooperation, inspirato al participatory journalism e guidato da un autore centrale
Creators: name: Laquidara, Giuseppe
name: Boém, Marika Mazzi
name: Colombani, Margaret
name: Jovenal, J.
Publisher: name: figshare
Year: 2013
Subjects: Literature
Applied Physics
Performing Arts
Applied Computer Science
Behavioral Neuroscience

description: "RIW" [portmanteau ger. "Revolution", "Ist", "Webber", also eng. "Revolutionist" "Webber"] is a quasi-MAB [quasi-Multi Authors Blog] maintaining both the centrality for a main author, and distributing its mechanism fulcrums as in the Theory of Networks, thus creating a participatory, polycentric, adaptive and genetic-growing platform. The model of the RIW is a hybrid between an organized multi-layers, hierarchical pyramid and a Network of networks [NNs], springing a fertile pattern for innovative political and social organizations. In this introductory paper, a famous Italian journalist's blog was taken as a starting example, currently maintained on Wordpress; Rivoluzione Italiana. According to the model used, the RIW can identify as a "cultural entity of the very long term," according to the principle of "Long Now", since the dynamics of his system naturally pushes the swing with long intervals.
BDNF val66met is a strong predictor of decision making and attention performance on the CONVIRT virtual reality cognitive battery
Creators: name: Corrone, Michelle
name: Nanev, Aleshia
name: Amato, Isabella
name: Bicknell, Rowena
name: Wundersitz, Daniel
name: van den Buuse, Maarten
name: Wright, Bradley
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: No description supplied
Design of thin film organic solar cells for optimum photovoltaic performance
Creators: name: Narayan, Monishka Rita
Publisher: name: Charles Darwin University
Year: 2013

description: Organic solar cells are a class of thin film solar cells that offer advantages of low-cost, flexibility, inexpensive fabrication techniques and large-scale production. However, the performance and stability of organic solar cells limit their commercialization. In this thesis, a theoretical study is carried out on the various operation mechanisms, including photo-generation of excitons, diffusion and dissociation of excitons and separation of charge carriers to their respective electrodes, in bulk-heterojunction organic solar cells. The analysis of results obtained from the above theoretical works is used in simulating optimal designs for two types of organic solar cells; bulk-heterojunction and hybrid structures. In this thesis, after the introductory chapter 1, the rates of excitation, diffusion and dissociation of excitons in bulk-heterojunction solar cells are derived, respectively, in the next three chapters of this thesis using the corresponding interaction operators, transition matrix elements and Fermi’s golden rule. The rate of excitation of singlet excitons is derived using the usual exciton-photon interaction operator as perturbation and that of triplet excitons is obtained using the new time-dependent exciton-spin-orbit-photon interaction operator which depends on the atomic number of the constituting atoms. Thus, the influence of incorporation of heavy metal atoms on the photo-generation of triplet excitons is also studied. The effect of excitonic binding energy and diffusion length on the performance of bulk-heterojunction solar cells is presented. A dissociation mechanism for the Frenkel excitons into free charge carriers at the donor-acceptor interface is proposed and possible loss mechanisms in bulk-heterojunction organic solar cells are discussed. In addition, the study of the optical properties of bulk-heterojunction and hybrid organic solar cells is presented in Chapter 5, together with their designs, which are optimized using the semiconducting thin film optics simulation software (SETFOS). The layer thicknesses have been optimized with respect to maximum photon absorption in the active layer and the optimal designs thus obtained produce high power conversion efficiencies of 12.87% and 4.70% in the bulk-heterojunction and hybrid organic solar cells, respectively. These efficiencies are found to be notable enhancements from their corresponding current experimental power conversion efficiencies. The results of this investigation are expected to contribute towards the fabrication of high-efficiency bulk-heterojunction and hybrid organic solar cells.
title: Die Implementation der IHRA-Arbeitsdefinition Antisemitismus ins deutsche Recht: eine rechtliche Beurteilung
Creators: name: Ambos, Kai
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2023
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
Fasciclin-like arabinogalactan-protein 16 (FLA16) is required for stem development in Arabidopsis
Creators: name: Liu, Edgar
name: MacMillan, Colleen P
name: Shafee, Thomas
name: Ma, Yingxuan
name: Ratcliffe, Julian
name: van de Meene, Allison
name: Bacic, Tony
name: Humphries, John
name: Johnson, Kim
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3004
subject: Crop and pasture production
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3108
subject: Plant biology

description: The predominant Fascilin 1 (FAS1)-containing proteins in plants belong to the Fasciclin-Like Arabinogalactan-protein (FLA) family of extracellular glycoproteins. In addition to FAS1 domains, these multi-domain FLA proteins contain glycomotif regions predicted to direct addition of large arabinogalactan (AG) glycans and many contain signal sequences for addition of a glycosylphosphatidylinositol (GPI)-anchor to tether them to the plasma membrane. FLAs are proposed to play both structural and signaling functions by forming a range of interactions in the plant extracellular matrix, similar to FAS1-containing proteins in animals. FLA group B members contain two FAS1 domains and are not predicted to be GPI-anchored. None of the group B members have been functionally characterized or their sub-cellular location resolved, limiting understanding of their function. We investigated the group B FLA16 in Arabidopsis that is predominantly expressed in inflorescence tissues. FLA16 is the most highly expressed FLA in the stem after Group A members FLA11 and FLA12 that are stem specific. A FLA16-YFP fusion protein driven by the endogenous putative FLA16 promoter in wild type background showed expression in cells with secondary cell walls, and FLA16 displayed characteristics of cell wall glycoproteins with moderate glycosylation. Investigation of a fla16 mutant showed loss of FLA16 leads to reduced stem length and altered biomechanical properties, likely as a result of reduced levels of cellulose. Immuno-labeling indicated support for FLA16 location to the plasma-membrane and (apoplastic) cell wall of interfascicular stem fiber cells. Together these results indicate FLA16, a two-FAS1 domain FLAs, plays a role in plant secondary cell wall synthesis and function.
Fasciclin-like arabinogalactan-protein 16 (FLA16) is required for stem development in Arabidopsis
Creators: name: Liu, Edgar
name: MacMillan, Colleen P
name: Shafee, Thomas
name: Yingxuan Ma
name: Ratcliffe, Julian
name: Meene, Allison Van De
name: Bacic, Tony
name: Humphries, John
name: Johnson, Kim
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The predominant Fascilin 1 (FAS1)-containing proteins in plants belong to the Fasciclin-Like Arabinogalactan-protein (FLA) family of extracellular glycoproteins. In addition to FAS1 domains, these multi-domain FLA proteins contain glycomotif regions predicted to direct addition of large arabinogalactan (AG) glycans and many contain signal sequences for addition of a glycosylphosphatidylinositol (GPI)-anchor to tether them to the plasma membrane. FLAs are proposed to play both structural and signaling functions by forming a range of interactions in the plant extracellular matrix, similar to FAS1-containing proteins in animals. FLA group B members contain two FAS1 domains and are not predicted to be GPI-anchored. None of the group B members have been functionally characterized or their sub-cellular location resolved, limiting understanding of their function. We investigated the group B FLA16 in Arabidopsis that is predominantly expressed in inflorescence tissues. FLA16 is the most highly expressed FLA in the stem after Group A members FLA11 and FLA12 that are stem specific. A FLA16-YFP fusion protein driven by the endogenous putative FLA16 promoter in wild type background showed expression in cells with secondary cell walls, and FLA16 displayed characteristics of cell wall glycoproteins with moderate glycosylation. Investigation of a fla16 mutant showed loss of FLA16 leads to reduced stem length and altered biomechanical properties, likely as a result of reduced levels of cellulose. Immuno-labeling indicated support for FLA16 location to the plasma-membrane and (apoplastic) cell wall of interfascicular stem fiber cells. Together these results indicate FLA16, a two-FAS1 domain FLAs, plays a role in plant secondary cell wall synthesis and function.
Discriminating verb meanings: The case of transfer verbs
Creators: name: Croft, William
name: Barðdal, Jóhanna
name: Hollmann, Willem
name: Nielsen, Maike
name: Sotirova, Violeta
name: Taoka, Chiaki
Publisher: name: Zenodo
Year: 2001

description: This is the handout of a talk given at the LAGB Meeting. It was often cited, but never written up.
Ab-initio pilots' performance using T-VASIS versus PAPI
Creators: name: J Perezgonzalez
Publisher: name: figshare
Year: 2013
Subjects: subject: Aerospace Engineering
subject: FOS: Mechanical engineering

description: Lewis (2011) compared the accuracy with which a group of ab-initio pilots tracked the correct approach-to-landing glide path when using two different approach lighting systems (T-VASIS and PAPI). Results show that pilots were better at tracking the correct glide slope in 8 scenarios out of 10 when using T-VASIS and in 2 scenarios out of 10 when using PAPI. On average, ab-initio pilots performed better with T-VASIS (mean difference = 6), a sensible difference of moderate magnitude (when attending to the unstandardized effect size). The main limitation of the study is that the low experience with flying may account for the variability in tracking the flight path (with T-VASIS offering more precise feedback than PAPI, thus the better performance). The results seem of little relevance to any other population than ab-inition pilots with 21 hours of flying experience.
The impact of COPD exacerbations in the year following pulmonary rehabilitation: Secondary analysis of a randomised controlled trial
Creators: name: Wageck, B
name: Cox, Narelle
name: McDonald, CF
name: Burge, Angela
name: Mahal, A
name: Hill, CJ
name: Lee, AL
name: Moore, R
name: Nicolson, Caroline
name: O'Halloran, Paul
name: Lahham, Aroub
name: Gillies, R
name: Holland, Anne
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3201
subject: Cardiovascular medicine and haematology
classificationCode: 3202
subject: Clinical sciences

description: © 2020 Wageck et al. Background: Pulmonary rehabilitation is an effective treatment for people with chronic obstructive pulmonary disease (COPD), but its benefits are poorly maintained. The aim of this study was to evaluate the impact of COPD exacerbations in the year following pulmonary rehabilitation on outcomes at 12 months. Methods: This was a secondary analysis from a trial of home versus hospital-based rehabilitation in COPD, with 12 months of follow-up. Moderate and severe exacerbations were identified using administrative data (prescriptions) and hospital records (admissions) respectively. The impact of exacerbations at 12 months following pulmonary rehabilitation was evaluated for quality of life (Chronic Respiratory Questionnaire, CRQ), dyspnea (mod-ified Medical Research Council, mMRC), exercise capacity (6-minute walk distance, 6MWD) and objectively measured physical activity (moderate-to-vigorous physical activity, MVPA). Results: A total of 166 participants were included, with mean age (SD) 69 (9) years and forced expiratory volume in one second (FEV1) 49 (19)% predicted. Moderate exacerbations occurred in 68% and severe exacerbations in 34% of participants. Experiencing a severe exacerbation was an independent predictor of worse 12-month outcomes for CRQ (total, fatigue and emotional function domains), mMRC, 6MWD and MVPA (all p<0.05). Participants who completed pulmonary rehabilitation were less likely to have a severe exacerbation (29% vs 48%, p=0.02). Severe exacerbations were more likely in those with worse baseline CRQ total (odds ratio 0.97, 95% CI 0.95 to 0.99) and FEV1%predicted (0.98, 95% CI 0.96 to 0.99). Conclusion: Severe exacerbations occur frequently following pulmonary rehabilitation and predict worse 12-month outcomes. Strategies to maintain the benefits of pulmonary rehabilitation should address exacerbation prevention and management.
Biology and modeling of self-organization in the New World army ant Eciton burchellii
Creators: name: Brown, Timothy
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 490104
subject: Complex systems
classificationCode: 460207
subject: Modelling and simulation
classificationCode: 310301
subject: Behavioural ecology
classificationCode: 310399
subject: Ecology not elsewhere classified
classificationCode: 310499
subject: Evolutionary biology not elsewhere classified
classificationCode: 310901
subject: Animal behaviour
classificationCode: 461301
subject: Coding, information theory and compression
classificationCode: 490102
subject: Biological mathematics

description: [PhD Thesis - originally published Nov 2006 - uploaded to Figshare for discoverablilty]ABSTRACT
The study of self-organization seeks to understand how complex system-level patterns emerge from the behavior of simple components within living systems. A significant challenge for such research is the lack of easy-to-use tools to quantify behaviors at the individual and system level. This work presents an effort to develop some of these tools and apply them to understanding the rules underlying self-organized swarming behavior in the New World army ant Eciton burchelliiE. burchellii swarms exhibit self-organization in that they collectively perform computationally complex tasks without centralized control and with access to only local information. To swarm successfully E. burchellii must spatially coordinate up to 200,000 nearly blind individuals of multiple castes in the face of changing biotic and abiotic factors. Large swarms can raid over an area larger than 2,000 m2 per day, processing and retrieving 30,000 or more prey. Swarms are robust to drastic changes in size and huge variations in substrate. Individuals have no means to measure overall spatial distribution or foraging success within different parts of the swarm. Self-organization provides evolution a mechanism by which selection on such simple individual behaviors can generate complex system-level patterns.In this thesis I examine the individual behavioral rules through which foraging swarms of E. burchellii are organized. To accomplish this, we measured the body positions of more than 30,000 ants in video of swarms from Costa Rica. From these data we generated a map approximating the pheromone landscape experienced by the ants. This landscape was matched with ant path data enabling us to quantitatively measure how E. burchellii army ants modify their turn angle and velocity in response to pheromone. Our measurements also provided evidence that ants of different lengths perform different functions in the swarm. These results were integrated into an individual-based computer model of army ant swarming that was tested against the video data.Our data and model results suggest that simple rules governing how velocity and turn angle change in response to variations in pheromone concentration and local ant density are enough to qualitatively reproduce many of the complex swarming behaviors observed in the field.
title: First Trial for Crimes Against Humanity in The Gambia Comes to an End
Creators: name: Freixo, Inês
name: Espinosa, Rodolfo González
name: Aboueldahab, Susann
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2023
Subjects: subject: 341

description: Völkerrechtsblog
The impact of COPD exacerbations in the year following pulmonary rehabilitation: Secondary analysis of a randomised controlled trial
Creators: name: B Wageck
name: Narelle Cox
name: CF McDonald
name: Burge, Angela
name: A Mahal
name: CJ Hill
name: AL Lee
name: R Moore
name: Nicolson, Caroline
name: O'Halloran, Paul
name: Aroub Lahham
name: R Gillies
name: Holland, Anne
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Wageck et al. Background: Pulmonary rehabilitation is an effective treatment for people with chronic obstructive pulmonary disease (COPD), but its benefits are poorly maintained. The aim of this study was to evaluate the impact of COPD exacerbations in the year following pulmonary rehabilitation on outcomes at 12 months. Methods: This was a secondary analysis from a trial of home versus hospital-based rehabilitation in COPD, with 12 months of follow-up. Moderate and severe exacerbations were identified using administrative data (prescriptions) and hospital records (admissions) respectively. The impact of exacerbations at 12 months following pulmonary rehabilitation was evaluated for quality of life (Chronic Respiratory Questionnaire, CRQ), dyspnea (mod-ified Medical Research Council, mMRC), exercise capacity (6-minute walk distance, 6MWD) and objectively measured physical activity (moderate-to-vigorous physical activity, MVPA). Results: A total of 166 participants were included, with mean age (SD) 69 (9) years and forced expiratory volume in one second (FEV1) 49 (19)% predicted. Moderate exacerbations occurred in 68% and severe exacerbations in 34% of participants. Experiencing a severe exacerbation was an independent predictor of worse 12-month outcomes for CRQ (total, fatigue and emotional function domains), mMRC, 6MWD and MVPA (all p<0.05). Participants who completed pulmonary rehabilitation were less likely to have a severe exacerbation (29% vs 48%, p=0.02). Severe exacerbations were more likely in those with worse baseline CRQ total (odds ratio 0.97, 95% CI 0.95 to 0.99) and FEV1%predicted (0.98, 95% CI 0.96 to 0.99). Conclusion: Severe exacerbations occur frequently following pulmonary rehabilitation and predict worse 12-month outcomes. Strategies to maintain the benefits of pulmonary rehabilitation should address exacerbation prevention and management.
Twice-Daily Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex Reduces Methamphetamine Craving: A Pilot Study.
Creators: name: Zhao, Di
name: Li, Yongqiang
name: Liu, Ting
name: Voon, Valerie
name: Yuan, Ti-Fei
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Transcranial magnetic stimulation (TMS) holds potential promise as a therapeutic modality for disorders of addiction. Our previous findings indicate that high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsal-lateral prefrontal cortex (DLPFC) and low-frequency rTMS over the right DLPFC can reduce drug craving for methamphetamine. One major issue with rTMS is the duration of treatment and hence potential dropout rate. Theta burst stimulation (TBS) has been recently shown to be non-inferior relative to repetitive transcranial magnetic stimulation for major depression. Here, we aim to compare the clinical efficacy and tolerability of intermittent and continuous theta burst stimulation protocols targeting left or right dorsolateral prefrontal cortex on methamphetamine craving in abstinent-dependent subjects. In this randomized single-blind pilot study, 83 abstinent methamphetamine-dependent subjects from a long-term residential treatment program were randomly allocated into three groups: intermittent theta burst stimulation (iTBS) over the left DLPFC (active group), continuous theta burst stimulation (cTBS) over the left DLPFC (active control group), or cTBS over the right DLPFC (active group) was administered twice daily over 5 days for a total of 10 sessions. We measured the primary outcome of cue-induced craving and secondarily sleep quality, depression, anxiety, impulsivity scores, and adverse effects. We show a pre- vs. postintervention effect on craving, which, on paired t tests, showed that the effect was driven by iTBS of the left DLPFC and cTBS of the right DLPFC, reducing cue-induced craving but not cTBS of the left DLPFC. We did not show the critical group-by-time interaction. The secondary outcomes of depression, anxiety, and sleep were unrelated to the improvement in craving in the left iTBS and right cTBS group. In the first two sessions, self-reported adverse effects were higher with left iTBS when compared to right cTBS. The distribution of craving change suggested greater clinical response (50% improvement) with right cTBS and a bimodal pattern of effect with left iTBS, suggesting high interindividual variable response in the latter. Accelerated twice-daily TBS appears feasible and tolerable at modulating craving and mood changes in abstinent methamphetamine dependence critically while reducing session length. We emphasize the need for a larger randomized controlled trial study with a sham control to confirm these findings and longer duration of clinically relevant follow-up. Chinese Clinical Trial Registry number, 17013610.
“RIW”, ~“RevolutionIstWebber”, Studio iniziale per un quasi-MAB [quasi-Multi Authors Blog] fondato su criteri partecipativi e di behavioural cooperation, inspirato al participatory journalism e guidato da una kernel-authorship centrale forte.
Creators: name: Laquidara, Giuseppe
name: Boém, Marika Mazzi
name: Colombani, Margaret
name: Jovenal, J.
Publisher: name: figshare
Year: 2013
Subjects: Literature
Applied Physics
Performing Arts
Applied Computer Science
Behavioral Neuroscience

description: "RIW" [portmanteau ger. "Revolution", "Ist", "Webber", also eng. "Revolutionist" "Webber"] is a quasi-MAB [quasi-Multi Authors Blog] maintaining both the centrality for a main author, and distributing its mechanism fulcrums as in the Theory of Networks, thus creating a participatory, polycentric, adaptive and genetic-growing platform. The model of the RIW is a hybrid between an organized multi-layers, hierarchical pyramid and a Network of networks [NNs], springing a fertile pattern for innovative political and social organizations. In this introductory paper, a famous Italian journalist's blog was taken as a starting example, currently maintained on Wordpress; Rivoluzione Italiana. According to the model used, the RIW can identify as a "cultural entity of the very long term," according to the principle of "Long Now", since the dynamics of his system naturally pushes the swing with long intervals.
When Frail Older People Relocate in Very Old Age, Who Makes the Decision?
Creators: name: Scheibl, Fiona
name: Farquhar, Morag
name: Buck, Jackie
name: Barclay, Stephen
name: Brayne, Carol
name: Fleming, Jane
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: Older people are likely to transition to a new home closer to family who can provide assistance or to long-term residential care as their health declines and their care needs increase. A minority choose to move to "age-friendly" housing before the onset of disability, but the majority prefer to "age in place" and defer moving until health crises compel a transition. Older people living with dementia are likely to move into residential care, but not much is known about the role they play in decision making around these moves. This qualitative study addresses this gap in knowledge by examining how a rare cohort of "older old" people, most with some level of cognitive impairment, were involved in decisions surrounding assistance seeking and moving to a care home. Thematic analysis of qualitative interview data from Cambridge City over-75s Cohort (CC75C) study participants aged 95 years and older, who had moved in later life, and their proxy informants (n = 26). Moves at such an old age were made due to a complexity of push and pull factors which had layered dynamics of decision making. In most cases (n = 22), decision making involved other people with varying degrees of decision ownership. Only four older people, who moved voluntarily, had full ownership of the decision to move. Many relatives reported being traumatized by events leading up to the move. "Older old" people are sometimes unable to make their own decisions about moving due to the urgency of health crisis and cognitive decline. There is a need to support relatives to discuss moving and housing options at timely junctures before health crises intervene in an effort to optimize older people's participation in decision making.
Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats
Creators: name: Schaik, John Van
name: Kettle, Christine
name: Green, Rodney
name: Sievers, William
name: Hale, Matthew
name: Irving, Helen
name: Whelan, Donna
name: JA Rathner
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021, The Author(s). The role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the brain implicated in stimulating BAT thermogenesis. This study tests the hypothesis that central administration of caffeine is sufficient to activate BAT. Low doses of caffeine administered either systemically (intravenous [IV]; 10 mg/kg) and centrally (intracerebroventricular [ICV]; 5–10 μg) increases BAT thermogenesis, in anaesthetised (1.5 g/kg urethane, IV) free breathing male rats. Cardiovascular function was monitored via an indwelling intra-arterial cannula and exhibited no response to the caffeine. Core temperature did not significantly differ after administration of caffeine via either route of administration. Caffeine administered both IV and ICV increased neuronal activity, as measured by c-Fos-immunoreactivity within subregions of the hypothalamic area, previously implicated in regulating BAT thermogenesis. Significantly, there appears to be no neural anxiety response to the low dose of caffeine as indicated by no change in activity in the basolateral amygdala. Having measured the physiological correlate of thermogenesis (heat production) we have not measured indirect molecular correlates of BAT activation. Nevertheless, our results demonstrate that caffeine, at stimulatory doses, acting via the central nervous system can increase thermogenesis, without adverse cardio-dynamic impact.