cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Investigation of Kentucky For-Hire Requirements
Creators: name: Martin, Andrew
name: Keathley, Valerie J.
name: Walton, Jennifer R.
Publisher: name: Kentucky Transportation Center, University of Kentucky
Year: 2018

description: This study analyzes the costs and benefits of the Kentucky For-Hire operating authority, which is issued to all carriers who pick up and drop off freight in Kentucky on a for-hire basis. It reviews current statutory and regulatory requirements, calculates the costs and benefits of administering Kentucky For-Hire, reviews the legal history of trucking regulation and deregulation, reports on a survey of other states about their practices with intrastate operating authority, and proposes three alternatives to current policies. The primary benefit of Kentucky For-Hire is that it enables the Kentucky Transportation Cabinet to verify carriers have commercial liability insurance. Several major challenges confront Kentucky For-Hire — the costs of administering the program exceed the revenue it generates, the requirement is loosely enforced, and violations potentially punish the commercial vehicle operator instead of the motor carrier owner or management. Each solution attempts to address one or more of these challenges. The study analyzes the benefits and challenges of the proposed policy alternatives. The report concludes with a supplementary chapter pertaining to the regulation of transportation network companies and parcel delivery service subcontractors.
description: Copyright:
© 2018 University of Kentucky, Kentucky Transportation Center
Statistik der Rechtspflege des Kantons Zürich 1874
Creators: name: (:Unkn) Unknown
Publisher: name: Bleuler-Hausheer & Cie.
Year: 1875
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 340 Recht
subject: Kanton Zürich
subject: Amtliche Statistik
subject: Rechtspflege

description: Rückwirkend nummeriert als Heft 10 der Stat. Mitteilungen betr. den Kanton Zürich.
title: Issues Pertaining to Rebuilt Vehicle Titles
Creators: name: Keathley, Valerie J.
name: Martin, Andrew
name: Koo, Jeeyen
name: Walton, Jennifer R.
Publisher: name: Kentucky Transportation Center, University of Kentucky
Year: 2019

description: In Kentucky, salvage titles are issued when a vehicle has been wrecked, destroyed, or damaged and the cost of repairs exceeds 75 percent of the vehicle’s fair market value. Once a vehicle is repaired to roadworthy condition it is issued a rebuilt title. Kentucky issued 110,000 rebuilt and salvage titles in 2018. Over the 2014 to 2018 period, the number of rebuilt and salvage titles issued climbed 31 percent. The economic impact of rebuilt and salvage titles in Kentucky is considerable — approximately $331 million in 2018, based on data for the taxable values or sales prices of vehicles.

To document titling practices for rebuilt and salvage vehicles adopted by other agencies, the Kentucky Transportation Center (KTC) distributed a survey to all American states and Canadian provinces and territories. From it, researchers learned that Ohio has a very robust inspection program for rebuilt and salvage vehicles. The survey and interviews with Ohio personnel revealed that other states have persistent concerns about Kentucky’s rebuilt and salvage titles. In particular, some states do not accept Kentucky’s red titles (rebuilt and salvage vehicles that were transferred into Kentucky). Ohio inspectors have identified multiple stolen vehicles that had been titled as rebuilt or salvage in the Commonwealth. To improve the rebuilt and salvage vehicle titling process, state administrators in the Division of Motor Vehicle Licensing could consider implementing a program similar to Ohio’s in terms of technology, workflow and the inspection cost assessed to individuals or businesses wishing to obtain a rebuilt or salvage title.
description: Copyright:
© 2018 University of Kentucky, Kentucky Transportation Center
幽门螺杆菌感染对人类肠道微生态结构的影响
Creators: name: Wang, Daoming
Publisher: name: CNGB
Year: 2022
Subjects: Raw sequence reads
Other
metagenomic raw sequence reads
Medical

description: Helicobacter pylori infection (HPI) is a prevalent infectious disease, associated with gastric ulcer, gastric cancer, and lots of non-gastrointestinal diseases. The effects of HPI on host may mediate by gut microbiome shift. We aim to evaluate the alterations of microbial functions and species abundance in the gut of HPI patients, and their potential associations with out-gastric HPI related diseases.
Le fonti del diritto al tempo dell’emergenza pandemica. Note su alcune tendenze in atto
Creators: name: Pastore, Baldassarre
Publisher: name: Società e diritti
Year: 2021

description: Riassunto Il contributo ha ad oggetto il rapporto che intercorre tra le fonti del diritto e la gestione dell’emergenza pandemica nell’ordinamento giuridico italiano. Tale questione si inserisce in alcune tendenze in atto riguardanti la complessità del diritto contemporaneo, che si articola in fonti di origine e autoritatività differenziate, in un contesto destrutturato, frammentato, fluido, reticolare che oscura il loro ordine gerarchico. In questo scenario, gioca un ruolo importante il soft law. Il disordine delle fonti si connette alle tematiche della certezza giuridica e dell’interpretazione.
description: Società e diritti, V. 6 N. 11 (2021): Pandemia, Criminologia e Diritti Umani
La Pandemia ed i suoi con-testi
Creators: name: Damiani Di Vergada Franzetti, Enrico
Publisher: name: Società e diritti
Year: 2021

description: Riassunto L'analisi della distanza tra prassi sociali e diritto spesso dimentica come tale rapporto necessariamente debba includere il contesto, l'ambiente fisico, naturale e umano, ove tale rapporto si svolge: i condizionamenti posti dall'ambiente fisico, naturale e umano, rappresentano e costituiscono altrettanti fattori in grado di condizionare l'agire socio-giuridico, dunque i soggetti, il diritto e il contesto ove tale agire si svolge. Si tratta di aspetti rispetto ai quali la politica, il diritto ma anche il contesto sociale spesso inseguono i problemi posti dalla società pandemica in continua e rapida trasformazione. Occorre dunque analizzare le implicazioni giuridiche dei “nuovi problemi sociali” connessi allo sviluppo, alla diffusione della pandemia mondiale da Covid-19 ovvero le conseguenze prodotte dai “fatti bruti”, fisici, naturali e umani, sull'agire socio-giuridico, sulla politica, sul diritto e sul contesto sociale. Parole chiave: pandemia - d
description: Società e diritti, V. 6 N. 11 (2021): Pandemia, Criminologia e Diritti Umani
Universal central extensions in semi-abelian categories
Creators: name: Casas, Jose Manuel
name: Van der Linden, Tim
Publisher: name: arXiv
Year: 2013
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 17A32, 18B99, 18E99, 18G50, 20J05

description: Basing ourselves on Janelidze and Kelly's general notion of central extension, we study universal central extensions in the context of semi-abelian categories. We consider a new fundamental condition on composition of central extensions and give examples of categories which do, or do not, satisfy this condition.
description: 12 pages, compact revised and published version of the paper arXiv:0908.3762
Broad Balmer line emission and cosmic ray acceleration efficiency in supernova remnant shocks
Creators: name: Morlino, G.
name: Blasi, P.
name: Bandiera, R.
name: Amato, E.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Balmer emission may be a powerful diagnostic tool to test the paradigm of cosmic ray (CR) acceleration in young supernova remnant (SNR) shocks. The width of the broad Balmer line is a direct indicator of the downstream plasma temperature. In case of efficient particle acceleration an appreciable fraction of the total kinetic energy of the plasma is channeled into CRs, therefore the downstream temperature decreases and so does the broad Balmer line width. This width also depends on the level of thermal equilibration between ions and neutral hydrogen atoms in the downstream. Since in general in young SNR shocks only a few charge exchange (CE) reactions occur before ionization, equilibration between ions and neutrals is not reached, and a kinetic description of the neutrals is required in order to properly compute Balmer emission. We provide a method for the calculation of Balmer emission using a self-consistent description of the shock structure in the presence of neutrals and CRs. We use a recently developed semi-analytical approach, where neutral particles, ionized plasma, accelerated particles and magnetic fields are all coupled together through the mass, momentum and energy flux conservation equations. The distribution of neutrals is obtained from the full Boltzmann equation in velocity space, coupled to Maxwellian ions through ionization and CE processes. The computation is also improved with respect to previous work thanks to a better approximation for the atomic interaction rates. We find that for shock speeds >2500km/s the distribution of broad neutrals never approaches a Maxwellian and its moments differ from those of the ionized component. These differences reflect into a smaller FWHM than predicted in previous calculations, where thermalization was assumed. The method presented here provides a realistic estimate of particle acceleration efficiency in Balmer dominated shocks.
description: 6 pages, 3 figures. Accepted for publication in Astronomy & Astrophysics
Scanning micro X-ray diffraction unveils the distribution of oxygen chains nano-puddles in YBa2Cu3O6.33
Creators: name: Campi, Gaetano
name: Ricci, Alessandro
name: Poccia, Nicola
name: Barba, Luisa
name: Arrighetti, Gianmichele
name: Burghammer, Manfred
name: Caporale, Alessandra-Stella
name: Bianconi, Antonio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Oxygen chain fragments are known to appear at the insulator to superconductor transition (SIT) in YBa2Cu3O6+y. However the self organization and the size distribution of oxygen chain fragments is not known. Here we contribute to fill this gap, using scanning micro X ray diffraction which is a novel imaging method based on advances in focusing synchrotron radiation beam. This novel approach allows us to probe both real-space and k-space of a high-quality YBa2Cu3O6.33 single crystals with Tc=7K. We report compelling evidence for nanoscale striped puddles, with Ortho-II structure, made of chain fragments in the basal Cu(1) plane with local oxygen concentration 0.5. The size of the Ortho-II puddles spans a range between 2 and 9 nanometers. The real space imaging of Ortho-II puddles granular network shows that superconductivity, at low hole-doping regime, occurs in a network of nanoscale oxygen ordered patches, interspersed with oxygen depleted regions. The manipulation by thermal treatments of the striped Ortho II puddles has been investigated focusing on the spontaneous symmetry breaking near the order to disorder phase transition at 350 K.
description: 6 pages, 5 Figures
Tunable polaronic conduction in anatase TiO2
Creators: name: Moser, S.
name: Moreschini, L.
name: Jacimovic, J.
name: Barisic, O. S.
name: Berger, H.
name: Magrez, A.
name: Chang, Y. J.
name: Kim, K. S.
name: Bostwick, A.
name: Rotenberg, E.
name: Forro, L.
name: Grioni, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Oxygen vacancies created in anatase TiO2 by UV photons (80 - 130 eV) provide an effective electron-doping mechanism and induce a hitherto unobserved dispersive metallic state. Angle resolved photoemission (ARPES) reveals that the quasiparticles are large polarons. These results indicate that anatase can be tuned from an insulator to a polaron gas to a weakly correlated metal as a function of doping and clarify the nature of conductivity in this material.
Third- and fourth-order constants of incompressible soft solids and the acousto-elastic effect
Creators: name: Destrade, Michel
name: Gilchrist, Michael D.
name: Saccomandi, G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Acousto-elasticity is concerned with the propagation of small-amplitude waves in deformed solids. Results previously established for the incremental elastodynamics of exact non-linear elasticity are useful for the determination of third- and fourth-order elastic constants, especially in the case of incompressible isotropic soft solids, where the expressions are particularly simple. Specifically, it is simply a matter of expanding the expression for $ρv^2$, where $ρ$ is the mass density and v the wave speed, in terms of the elongation $e$ of a block subject to a uniaxial tension. The analysis shows that in the resulting expression: $ρv^2 = a + be + ce^2$, say, $a$ depends linearly on $μ$; $b$ on $μ$ and $A$; and $c$ on $μ$, $A$, and $D$, the respective second-, third, and fourth-order constants of incompressible elasticity, for bulk shear waves and for surface waves.
description: 14 pages
Current-induced asymmetries of incompressible stripes in narrow quantum Hall systems
Creators: name: Gerhardts, Rolf R.
name: Panos, Konstantinos
name: Weis, Jürgen
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present recent experimental results confirming previously predicted strong asymmetries of the current distribution in narrow Hall bars under the conditions of the integer quantum Hall effect (IQHE). Using a previously developed self-consistent screening and transport theory of the IQHE, we investigate how these asymmetries, which are due to a non-linear feedback effect of the imposed current on the electron distribution in the sample, depend on relevant parameters, such as the strength of the imposed current, the magnetic field, the temperature, and the collision broadening of the Landau-quantized energy bands. We find that many aspects of the experimental results can be understood within this approach, whereas other aspects require explicit consideration of mechanism, which enforce the breakdown of the IQHE.
description: 15 pages, 11 figures
Statistik der Rechtspflege des Kantons Zürich 1878
Creators: name: (:Unkn) Unknown
Publisher: name: Bleuler-Hausheer & Cie.
Year: 1879
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 340 Recht
subject: Kanton Zürich
subject: Amtliche Statistik
subject: Rechtspflege

description: Rückwirkend nummeriert als Heft 14 der Stat. Mitteilungen betr. den Kanton Zürich.
Cosmic Ray acceleration and Balmer emission from SNR 0509-67.5
Creators: name: Morlino, G.
name: Blasi, P.
name: Bandiera, R.
name: Amato, E.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Context: Observation of Balmer lines from the region around the forward shock of supernova remnants may provide precious information on the shock dynamics and on the efficiency of particle acceleration at the shock. Aims: We calculate the Balmer line emission and the shape of the broad Balmer line for parameter values suitable for SNR 0509-67.5, as a function of the cosmic ray acceleration efficiency and of the level of thermal equilibration between electrons and protons behind the shock. This calculation aims at using the width of the broad Balmer line emission to infer the cosmic ray acceleration efficiency in this remnant. Methods: We use the recently developed non-linear theory of diffusive shock acceleration in the presence of neutrals. The semi-analytical approach that we developed includes a description of magnetic field amplification as due to resonant streaming instability, the dynamical reaction of both accelerated particles and turbulent magnetic field on the shock, and all channels of interaction between neutral atoms and background plasma that change the shock dynamics. Results: We achieve a quantitative assessment of the CR acceleration efficiency in SNR 0509-67.5 as a function of the shock velocity and different levels of electron-proton thermalization in the shock region. If the shock moves faster than ~4500 km/s, one can conclude that particle acceleration must be taking place with efficiency of several tens of percent. For lower shock velocity the evidence for particle acceleration becomes less clear because of the uncertainty in the electron-ion equilibration downstream. We also discuss the role of future measurements of the narrow Balmer line.
description: 7 pages, 5 figure. Accepted for publication in Astronomy & Astrophysics
Statistik der Rechtspflege des Kantons Zürich 1880
Creators: name: (:Unkn) Unknown
Publisher: name: Bleuler-Hausheer & Cie.
Year: 1881
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 340 Recht
subject: Kanton Zürich
subject: Amtliche Statistik
subject: Rechtspflege

description: Rückwirkend nummeriert als Heft 18 der Stat. Mitteilungen betr. den Kanton Zürich.
HRD Predicts Response to Platinum Therapy in Chinese EOC
Creators: name: 陈冬菊(Dongju Chen)
Publisher: name: CNGB
Year: 2022
Subjects: Variation
Multiisolate
Medical

description: This is the first study to investigate the clinical significance of HRD in Chinese EOC patients as we know. We use 22 tumor cell lines and 160 patients to establish a biological HRD threshold as 30, and then analyze the relationship between the HRD status of 150 Chinese patients with ovarian cancer and the efficacy of platinum-based chemotherapy. Furtherly, this study also evaluates the proportion of HRD status in Chinese ovarian cancer patients, the correlation between HRD scores and BRCA1/2 mutations, and its correlation with the efficacy of platinum-containing chemotherapy. This study will provide a powerful data basis for the next study of HRD in Chinese ovarian cancer patients as a biomarker for PARP inhibitors efficacy prediction.
Statistik der Rechtspflege des Kantons Zürich 1875
Creators: name: (:Unkn) Unknown
Publisher: name: Bleuler-Hausheer & Cie.
Year: 1876
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 340 Recht
subject: Kanton Zürich
subject: Amtliche Statistik
subject: Rechtspflege

description: Rückwirkend nummeriert als Heft 11 der Stat. Mitteilungen betr. den Kanton Zürich.
Analysis of Wharton's jelly mesenchymal stem cell heterogeneity by combining single cell and Spatial transcriptome sequencing
Creators: name: 陈小松(Xiaosong Chen)
Publisher: name: CNGB
Year: 2022
Subjects: Transcriptome or Gene expression
Monoisolate
Medical

description: Single-cell RNA sequencing: Fresh umbilical cords were collected. We isolated mesenchymal stem cell from Wharton's jelly of umbilical cord ( WJ-MSCs) using tissue block culture methods, and obtained passage 3 (P3) cells by in vitro expansion. After the preparation of single-cell suspensions, 10x Genomic scRNA-seq and bioinformatics analysis were performed to draw the heterogeneity maps of WJ-MSCs from transcriptome level. Spatial transcriptome: Two fresh umbilical cords homologous to scRNA-seq were selected to prepare the tissue blocks with a length of 3 cm were prepared at the maternal and fetal ends of umbilical cord, respectively. ST sequencing technology was used to draw the spatial expression maps between and within wharton's jelly tissue regions.
Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer -sequencing data
Creators: name: 殷, 建华
Publisher: name: CNGB
Year: 2022
Subjects: Raw sequence reads
Multiisolate

description: Cancer-associated fibroblasts (CAFs) play a role in cancer treatment response and thereby affect patient prognosis. CAFs contain phenotypically and functionally heterogeneous subpopulations and differed widely in tumors of different tissue origin.Using single-cell RNA sequencing of bladder cancer (BC), we discovered a previously unidentified CAF subpopulation characterized by urea transporter SLC14A1 overexpression. Mechanistically, this population, which could be induced by interferon signaling, confers stemness to bladder cancer cells via WNT5A paracrine pathway. By delineating the source of interferons, we reveal a link between cGAS-STING signaling and SLC14A1 + CAFs differentiation. Furthermore, inhibition of SLC14A1 + CAFs formation via targeting STAT1 or STING could sensitize tumor cells to chemo therapy. More importantly, patients with high proportions of SLC14A1 + CAFs in their BC showed cancer stage independent poor outcome and worse response rate towards neoadjuvant chemotherapy (NAC) or immunotherapy. Single-cell RNA sequencing data for 16 samples from 8 bladder cancer patients, including 8 primary bladder tumor tissues and matching para-cancerous mucosa
INNOVATIVE TRENDS IN ENTREPRENEURSHIP:  Need, Opportunities and Challenges
Creators: name: PANDEY, SHIVAM
Publisher: name: RED'SHINE PUBLICATION PVT. LTD
Year: 2023
Subjects: INNOVATIVE TRENDS IN ENTREPRENEURSHIP: Need, Opportunities and Challenges

description: Edited Peer Reviewed Book on INNOVATIVE TRENDS IN ENTREPRENEURSHIP: Need, Opportunities and Challenges
Jet measurements in proton-proton collisions with the ALICE experiment at LHC
Creators: name: Vajzer, Michal
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The study of jets, collimated sprays of particles associated with hard partons, is an important tool in testing perturbative quantum chromodynamics (pQCD) and probing hot and dense nuclear matter created in high energy heavy-ion collisions. Jets enable the study of hard scatterings, fragmentation and hadronisation and their modification in the presence of a nuclear medium with respect to baseline vacuum measurements, which is acquired from jet measurements in proton-proton collisions. We have analysed data from proton-proton collisions at s= \sqrt{s} = 7 TeV measured by the ALICE experiment at the LHC and reconstructed the inclusive spectra of charged particle jets at mid- rapidity using anti-kT clustering algorithm. We present the jet spectra corrected for detector effects using several unfolding methods. Furthermore, we examine various properties of jets, such as their charged particle multiplicity and jet shapes.
description: 4 pages & 5 figures
Statistik der Rechtspflege des Kantons Zürich 1876
Creators: name: (:Unkn) Unknown
Publisher: name: Bleuler-Hausheer & Cie.
Year: 1877
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 340 Recht
subject: Kanton Zürich
subject: Amtliche Statistik
subject: Rechtspflege

description: Rückwirkend nummeriert als Heft 12 der Stat. Mitteilungen betr. den Kanton Zürich.
title: Инновационные приемы в практике преподавания РКИ. Предложно-падежная система русского языка (приемы fishbone и mind-map). Уровни А1, А2, В1
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2021

description: В учебно-методическом пособии объясняются алгоритмы работы с инновационными приемами графического представления информации: издание содержит графическое представление предложно-падежной системы современного русского языка согласно инновационным приемам fishbone и mind-map. Для элементарного уровня владения РКИ значения падежей даны в виде схемы fishbone, для базового и I сертификационного уровней владения РКИ значения падежей представлены в mind-map («интеллект-картах»). Применение предложенных инновационных приемов на уроках РКИ способствует более эффективному усвоению предложно-падежной системы и предотвращает ошибки, связанные со смешением падежных значений. Учебно-методическое пособие адресовано преподавателям-филологам и всем изучающим русский язык как иностранный.
Statistik der Rechtspflege des Kantons Zürich 1879
Creators: name: (:Unkn) Unknown
Publisher: name: Bleuler-Hausheer & Cie.
Year: 1880
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 340 Recht
subject: Kanton Zürich
subject: Amtliche Statistik
subject: Rechtspflege

description: Rückwirkend nummeriert als Heft 16 der Stat. Mitteilungen betr. den Kanton Zürich.
BGIphageX_TUdelft
Creators: name: 宋, 文琛
Publisher: name: CNGB
Year: 2022
Subjects: Genome sequencing and assembly
Genome sequencing
Metagenomic assembly
Environment
Environmental

description: 立足于基因组学，合成生物学研究与噬菌体相关的环境微生物，探究研究相关作用机制
title: ВЛИЯНИЕ ПСИХОАКТИВНЫХ ВЕЩЕСТВ НА ПСИХИЧЕСКОЕ ЗДОРОВЬЕ ЧЕЛОВЕКА В КОНТЕКСТЕ СОВРЕМЕННОГО ОККУЛЬТИЗМА
Creators: name: Борисова, А.
name: Лашкова , В.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье рассмотрено влияние психоактивных веществ, а именно наркотических, на психическое здоровье человека, и следствие после применения данных препаратов. В тексте используется пример из магистерской диссертации по антропологии и нового религиозного культа в виде идейной общины, на которых основаны научные результаты данной статьи по влиянию психоактивных веществ на психику человека. Особое внимание
обращается на возрастной контингент, так как большинство студентов и преподавателей относятся именно к возрасту риска, что необходимо для предупреждения населения. По последним данным 2020 года Россия заняла лидирующее положение по изъятым психоактивным веществам, что составило 35 600 кг (второе место в мире после Европы). По сравнению с другими работами данная статья сравнивает два религиозных учения,
основанных на применении различных препаратов, и дает оценку влияния данных веществ на психическое здоровье человека. В заключении делается вывод о негативном влиянии психоактивных веществ на психику человека.
Double focus in the modelling of anti-influenza properties of 2-iminobenzimidazolines: pharmacology and toxicology
Creators: name: Pereira, I.V.
name: de Freitas, M.P.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: Influenza affects millions of people globally and the appearance of drug-resistant strains is an ongoing problem. Therefore, this work reports the development of quantitative structure-activity relationship (QSAR) models to predict some biological properties of new 2-iminobenzimidazoline candidates for the treatment of the flu. A series of 2-iminobenzimidazoline derivatives with experimentally available values for cytotoxicity (pCC50) and anti-influenza activity (pIC50) was used for multivariate image analysis applied to QSAR (MIA-QSAR). The models were vigorously validated according to the best practices in QSAR and the chemical features responsible for the response variables were analysed based on MIA-plots, which assess the PLS regression coefficients and variable importance in projection scores. MIA descriptors encoding atomic properties (van der Waals radius and electronegativity) were capable of properly modelling the pCC50 and pIC50 data. The internally and externally validated models were used to predict the selectivity indexes (SI = pCC50/pIC50) of unprecedented analogues, which were designed upon analysis of the MIA-plots that show the substituent groups most affecting the biological data and by the combination of substructures of selected molecules. At least three promising anti-influenza candidates could be proposed from the predictive MIA-QSAR models.
Insights into effect of the Asp25/Asp25ʹ protonation states on binding of inhibitors Amprenavir and MKP97 to HIV-1 protease using molecular dynamics simulations and MM-GBSA calculations
Creators: name: Yu, Y.X.
name: Wang, W.
name: Sun, H.B.
name: Zhang, L.L.
name: Wu, S.L.
name: Liu, W.T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The protonation states of two aspartic acids in the catalytic strands of HIV-1 protease (PR) remarkably affect bindings of inhibitors to PR. It is requisite for the design of potent inhibitors towards PR to investigate the influences of Asp25/Asp25ʹ protonated states on dynamics behaviour of PR and binding mechanism of inhibitors to PR. In this work, molecular dynamics (MD) simulations, MM-GBSA method and principal component (PC) analysis were coupled to explore the effect of Asp25/Asp25′ protonation states on conformational changes of PR and bindings of Amprenavir and MKP97 to PR. The results show that the Asp25/Asp25′ protonation states exert different impacts on structural fluctuations, flexibility and motion modes of PR. Dynamics analysis verifies that Asp25/Asp25ʹ protonated states highly affect conformational dynamics of two flaps in PR. The binding free energy calculations results suggest that the Asp25/Asp25ʹ protonated states obviously strengthen bindings of inhibitors to PR compared to the non-protonation state. Calculations of residue-based free energy decomposition indicate that the Asp25/Asp25ʹ protonation not only disturbs the interaction network of inhibitors with PR but also stabilizes bindings of inhibitors to PR by cancelling the electrostatic repulsive interaction. Therefore, special attentions should be paid to the Asp25/Asp25ʹ protonation in the design of potent inhibitors towards PR.
Gravitationally Driven Electromagnetic Perturbations of Neutron Stars and Black Holes
Creators: name: Sotani, Hajime
name: Kokkotas, Kostas D.
name: Laguna, Pablo
name: Sopuerta, Carlos F.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Gravitational perturbations of neutron stars and black holes are well known sources of gravitational radiation. If the compact object is immersed in or endowed with a magnetic field, the gravitational perturbations would couple to electromagnetic perturbations and potentially trigger synergistic electromagnetic signatures. We present a detailed analytic calculation of the dynamics of coupled gravitational and electromagnetic perturbations for both neutron stars and black holes. We discuss the prospects for detecting the electromagnetic waves in these scenarios and the potential that these waves have for providing information about their source.
description: accepted for publication in PRD
Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer -count matrix
Creators: name: 建华 殷
Publisher: name: CNGB
Year: 2022
Subjects: Transcriptome or Gene expression
Multiisolate

description: Cancer-associated fibroblasts (CAFs) play a role in cancer treatment response and thereby affect patient prognosis. CAFs contain phenotypically and functionally heterogeneous subpopulations and differed widely in tumors of different tissue origin.Using single-cell RNA sequencing of bladder cancer (BC), we discovered a previously unidentified CAF subpopulation characterized by urea transporter SLC14A1 overexpression. Mechanistically, this population, which could be induced by interferon signaling, confers stemness to bladder cancer cells via WNT5A paracrine pathway. By delineating the source of interferons, we reveal a link between cGAS-STING signaling and SLC14A1 + CAFs differentiation. Furthermore, inhibition of SLC14A1 + CAFs formation via targeting STAT1 or STING could sensitize tumor cells to chemo therapy.More importantly, patients with high proportions of SLC14A1 + CAFs in their BC showed cancer stage independent poor outcome and worse response rate towards neoadjuvant chemotherapy (NAC) or immunotherapy The scRNA-seq count matrix for 16 samples from 8 bladder cancer patients, including 8 primary bladder tumor tissues and matching para-cancerous mucosa.
Rare-event trajectory ensemble analysis reveals metastable dynamical phases in lattice proteins
Creators: name: Mey, Antonia S. J. S.
name: Geissler, Phillip L.
name: Garrahan, Juan P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We explore the dynamical large-deviations of a lattice heteropolymer model of a protein by means of path sampling of trajectories. We uncover the existence of non-equilibrium dynamical phase-transitions in ensembles of trajectories between active and inactive dynamical phases, whose nature depends on properties of the interaction potential. When the full heterogeneity of interactions due to the amino-acid sequence is preserved, as in a fully interacting model or in a heterogeneous version of the Gō model where only native interactions are considered, the transition is between the equilibrium native state and a highly native but kinetically trapped state. In contrast, for the homogeneous Gō model, where there is a single native energy and the sequence plays no role, the dynamical transition is a direct consequence of the static bi-stability between unfolded and native states. In the heterogeneous case the native-active and native-inactive states, despite their static similarity, have widely varying dynamical properties, and the transition between them occurs even in lattice proteins whose sequences are designed to make them optimal folders.
description: 9 pages, 9 figures, paper + supplementary material
A Framework for Linear Stability Analysis of Finite-Area Vortices
Creators: name: Elcrat, Alan
name: Protas, Bartosz
Publisher: name: arXiv
Year: 2012
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Numerical Analysis (math.NA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this investigation we revisit the question of the linear stability analysis of 2D steady Euler flows characterized by the presence of compact regions with constant vorticity embedded in a potential flow. We give a complete derivation of the linearized perturbation equation which, recognizing that the underlying equilibrium problem is of the free-boundary type, is done systematically using methods of the shape-differential calculus. Particular attention is given to the proper linearization of the contour integrals describing vortex induction. The thus obtained perturbation equation is validated by analytically deducing from it the stability analyses of the circular vortex, originally due to Kelvin (1880), and of the elliptic vortex, originally due to Love (1893), as special cases. We also propose and validate a spectrally-accurate numerical approach to the solution of the stability problem for vortices of general shape in which all singular integrals are evaluated analytically.
description: 22 pages, 2 figures (accepted for publication in the "Proceedings of the Royal Society A")
title: COVID-19 И КОМБИНИРОВАННЫЕ ОРАЛЬНЫЕ КОНТРАЦЕПТИВЫ КАК ПРИЧИНЫ ТРОМБООБРАЗОВАНИЯ. КЛИНИЧЕСКИЙ СЛУЧАЙ
Creators: name: Волкова, З.
name: Иванова, А.
name: Кокорина, Е.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Вопросы тромбообразования актуальны как в рассмотрении механизма патогенеза, так и в подборе антикоагулянтной терапии. Острое нарушение мозгового кровообращения (ОНМК) является важной медико-социальной проблемой и особый интерес представляет у людей трудоспособного возраста. Важно учитывать не только типичные причины тромбозов (тромбовоспаление, гиперкоагуляция), но и другие, например, приём
эстрогенсодержащих препаратов. В клиническом исследовании, представленном в данной статье, на примере клинического случая отражена чёткая связь некорректного приёма эстрогенсодержащего средства, перенесённого COVID-19 в возникновении ОНМК. Это доказывает, что при назначении комбинированных оральных контрацептивов необходим тщательный сбор анамнеза.
An exact real-space renormalization method and applications
Creators: name: Feiguin, Adrian E.
name: Somma, Rolando D.
name: Batista, Cristian D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a numerical method based on real-space renormalization that outputs the exact ground space of "frustration-free" Hamiltonians. The complexity of our method is polynomial in the degeneracy of the ground spaces of the Hamiltonians involved in the renormalization steps. We apply the method to obtain the full ground spaces of two spin systems. The first system is a spin-1/2 Heisenberg model with four-spin cyclic-exchange interactions defined on a square lattice. In this case, we study finite lattices of up to 160 spins and find a triplet ground state that differs from the singlet ground states obtained in C.D. Batista and S. Trugman, Phys. Rev. Lett. 93, 217202 (2004). We characterize such a triplet state as consisting of a triplon that propagates in a background of fluctuating singlet dimers. The second system is a family of spin-1/2 Heisenberg chains with uniaxial exchange anisotropy and next-nearest neighbor interactions. In this case, the method finds a ground-space degeneracy that scales quadratically with the system size and outputs the full ground space efficiently. Our method can substantially outperform methods based on exact diagonalization and is more efficient than other renormalization methods when the ground-space degeneracy is large.
description: 10 pages, 8 Figs. Typos corrected
Unusual Kondo physics in a Co impurity atom embedded in noble-metal chains
Creators: name: Di Napoli, S.
name: Barral, M. A.
name: Roura-Bas, P.
name: Aligia, A. A.
name: Mokrousov, Y.
name: Llois, A. M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We analyze the conduction bands of the one dimensional noble-metal chains that contain a Co magnetic impurity by means of ab initio calculations. We compare the results obtained for Cu and Ag pure chains, as well as O doped Cu, Ag and Au chains with those previously found for Au pure chains. We find similar results in the case of Cu and Au hosts, whereas for Ag chains a different behavior is obtained. Differences and similarities among the different systems are analyzed by comparing the electronic structure of the three noble-metal hosts. The d-orbitals of Cu chains at the Fermi level have the same symmetry as in the case of Au chains. These orbitals hybridize with the corresponding ones of the Co impurity, giving rise to the possibility of exhibiting a two-channel Kondo physics.
description: Accepted in IEEE Trans. Magn. - April 2013
Coulomb corrections to density and temperature of bosons in heavy ion collisions
Creators: name: Zheng, Hua
name: Giuliani, Gianluca
name: Bonasera, Aldo
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A recently proposed method, based on quadrupole and multiplicity fluctuations in heavy ion collisions, is modified in order to take into account distortions due to the Coulomb field. This is particularly interesting for bosons produced in heavy ion collisions, such as $d$ and $α$ particles. We derive temperatures and densities seen by the bosons and compare to similar calculations for fermions. The resulting energy densities agree rather well with each other and with the one derived from neutrons. This suggests that a common phenomenon, such as the sudden opening of many reaction channels and/or a liquid gas phase transition, is responsible for the agreement.
description: arXiv admin note: substantial text overlap with arXiv:1305.5494. Accepted for publication in Phys. Rev. C
Insight into the structural requirement of aryl sulphonamide based gelatinases (MMP-2 and MMP-9) inhibitors – Part I: 2D-QSAR, 3D-QSAR topomer CoMFA and Naïve Bayes studies – First report of 3D-QSAR Topomer CoMFA analysis for MMP-9 inhibitors and jointly inhibitors of gelatinases together
Creators: name: Das, S.
name: Amin, S.A.
name: Jha, T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Gelatinases [gelatinase A – matrix metalloproteinase-2 (MMP-2), gelatinase B – matrix metalloproteinase-9 (MMP-9)] play key roles in many disease conditions including cancer. Despite some research work on gelatinases inhibitors both jointly and individually had been reported, challenges still exist in achieving potency as well as selectivity. Here in part I of a series of work, we have reported the structural requirement of some arylsulfonamides. In particular, regression-based 2D-QSARs, topomer CoMFA (comparative molecular field analysis) and Bayesian classification models were constructed to refine structural features for attaining better gelatinase inhibitory activity. The 2D-QSAR models exhibited good statistical significance. The descriptors nsssN, SHBint6, SHBint7, PubchemFP629 were directly correlated with the MMP-2 binding affinities whereas nsssN, SHBint10 and AATS2i were directly proportional to MMP-9 binding affinities. The topomer CoMFA results indicated that the steric and electrostatic fields play key roles in gelatinase inhibition. The established Naïve Bayes prediction models were evaluated by fivefold cross validation and an external test set. Furthermore, important molecular descriptors related to MMP-2 and MMP-9 binding affinities and some active/inactive fragments were identified. Thus, these observations may be helpful for further work of aryl sulphonamide based gelatinase inhibitors in future.
Phase Diagram of a Spin-Orbit Coupled Fermi Gases in a Bilayer Optical Lattice
Creators: name: Yang, Xiaosen
name: Huang, Beibing
name: Lin, Hai-Qing
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate the stability of helical superfluid phase in a spin-orbit coupled Fermi gas loaded in a bilayer optical lattice. The phase diagram of the system is constructed in the mean field framework. We investigate the topological properties of the superfluid phases by a nontrivial application of the Fermi surface topological invariant to our time-reversal invariant system with degeneracies on the Fermi surface. We find that there is a first-order phase boundary in the phase diagram of half filling case and the superfluid phases are all topological trivial. The superfluid phase is topological nontrivial when the filling fraction deviates from the half filling. In the topological nontrivial superfluid phase, a full pairing gap exists in the bulk and gapless helical Majorana edge states exist at the boundary.
description: 6 pages, 3 figures
Nuclear effective charge factor originating from covariant density functional theory
Creators: name: Niu, Z. M.
name: Liu, Q.
name: Niu, Y. F.
name: Long, W. H.
name: Guo, J. Y.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Guiding by the relativistic local density approximation, we explore a phenomenological formula for the coupling strength of Coulomb field to take into account the Coulomb exchange term effectively in the relativistic Hartree approximation. Its validity in finite nuclei is examined by comparing with the exact treatment of the Coulomb exchange energies in the relativistic Hartree-Fock-Bogoliubov approach. It is found that the exact Coulomb exchange energies can be reproduced by employing the phenomenological formula with the relative deviations less than 1% for semi-magic Ca, Ni, Sn, and Pb isotopes. Furthermore, we check the applicability of the phenomenological formula for the effective interactions in the relativistic Hartree approach by investigating the binding energy differences of mirror nuclei.
description: 10 pages, 4 figures
Proximity breakdown of hydrides in superconducting niobium cavities
Creators: name: Romanenko, A.
name: Barkov, F.
name: Cooley, L. D.
name: Grassellino, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Many modern and proposed future particle accelerators rely on superconducting radio frequency cavities made of bulk niobium as primary particle accelerating structures. Such cavities suffer from the anomalous field dependence of their quality factors Q0. High field degradation - so-called high field Q-slope - is yet unexplained even though an empirical cure is known. Here we propose a mechanism based on the presence of proximity-coupled niobium hydrides, which can explain this effect. Furthermore, the same mechanism can be present in any surface-sensitive experiments or superconducting devices involving niobium.
Skyrmion crystals in the pseudo-spin-1/2 Bose-Einstein condensates
Creators: name: Zhang, Cong
name: Guo, Wenan
name: Feng, Shiping
name: Yang, Shi-Jie
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Exact two-dimensional solutions are constructed for the pseudo-spin-1/2 Bose-Einstein condensates which are described by the coupled nonlinear Gross-Pitaevskii equations where the intraspecies and interspecies coupling constants are assumed to be equal. The equations are decoupled by means of re-combinations of the nonlinear terms of the hyperfine states according to the spatial dimensions. These stationary solutions form various spin textures which are identified as skyrmion crystals. In a special case, the crystal of skyrmion-antiskyrmion pairs is formed in the soliton limit.
description: 7 figures
The AdS3 x S3 x S3 x S1 Hernandez-Lopez Phases: a Semiclassical Derivation
Creators: name: Abbott, Michael C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This note calculates the Hernandez-Lopez phases for strings in AdS3 x S3 x S3 x S1 by semiclassical methods using the d(2,1;α)^2 algebraic curve. By working at general α we include modes absent from previous semiclassical calculations of this phase in AdS3 x S3 x T4, and in particular can study the scattering of particles of different mass. By carefully re-deriving the semiclassical formula we clarify some issues of antisymmetrisation, cutoffs and surface terms which could safely be ignored in AdS5 x S5, and some issues about the terms c_1,s which were absent there. As a result we see agreement with the recently calculated all-loop dressing phase in the AdS3 x S3 x T4 case, and exactly 1/2 this in the general case AdS3 x S3 x S3 x S1 for any α and any (light) polarisations.
description: 17 pages. v2 has new sections 3.2 and 3.3, fixes typos, adds references