cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
3D Hydrodynamic Simulations of the Galactic Supernova Remnant CTB 109
Creators: name: Bolte, Jan
name: Sasaki, Manami
name: Breitschwerdt, Dieter
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using detailed 3D hydrodynamic simulations we study the nature of the Galactic supernova remnant (SNR) CTB 109 (G109.1-1.0), which is well-known for its semicircular shape and a bright diffuse X-ray emission feature inside the SNR. Our model has been designed to explain the observed morphology, with a special emphasis on the bright emission feature inside the SNR. Moreover, we determine the age of the remnant and compare our findings with X-ray observations. With CTB 109 we test a new method of detailed numerical simulations of diffuse young objects, using realistic initial conditions derived directly from observations. We performed numerical 3D simulations with the RAMSES code. The initial density structure has been directly taken from $^{12}$CO emission data, adding an additional dense cloud, which, when it is shocked, causes the bright emission feature. From parameter studies we obtained the position $(\ell , b)=(109.1545^\circ , -1.0078^\circ)$ for an elliptical cloud with $n_\text{cloud}=25~\text{cm}^{-3}$ based on the preshock density from Chandra data and a maximum diameter of 4.54 pc, whose encounter with the supernova (SN) shock wave generates the bright X-ray emission inside the SNR. The calculated age of the remnant is about 11,000 yr according to our simulations. In addition, we can also determine the most probable site of the SN explosion. Hydrodynamic simulations can reproduce the morphology and the observed size of the SNR CTB 109 remarkably well. Moreover, the simulations show that it is very plausible that the bright X-ray emission inside the SNR is the result of an elliptical dense cloud shocked by the SN explosion wave. We show that numerical simulations using observational data for an initial model can produce meaningful results.
description: 9 pages, 6 figures, accepted for publication in A&A
(101207) Ellen Louise Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Co-delivery of Cisplatin and Rapamycin for Enhanced Anticancer Therapy through Synergistic Effects and Microenvironment Modulation
Creators: name: Miao, Lei
name: Guo, Shutao
name: Xu, Zhenghong
name: Huang, Leaf
name: Wang, Yuhua
name: Lin, C. Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The tumor microenvironment plays an important role in the tumor’s progression and metastasis. Therefore, successful alteration of this delicate setting against the tumor’s favor can open a window for therapeutic efficacy. We have developed a modality to bring about treatment-induced alterations in the tumor microenvironment by employing the synergistic effects between two drugs. Co-delivery of rapamycin (RAPA), an mTOR inhibitor that may offer notable therapy through antiangiogenic activity, alongside cisplatin can foster significant potency as RAPA sensitizes A375 melanoma cells to cisplatin therapy through microenvironment modulation. However, encapsulation of these drugs into poly(lactic-co-glycolic acid) (PLGA) NPs was inefficient due to the incompatibility between the two free drugs and the polymer matrix. Here, we show cisplatin can be made hydrophobic by coating a nanoprecipitate (cores) of the drug with dioleoylphosphatidic acid (DOPA). These DOPA coated cisplatin cores are compatible with PLGA and can be coencapsulated in PLGA NPs alongside RAPA at a molar ratio to promote synergistic antitumor activity. The presence of the cisplatin cores significantly improved the encapsulation of RAPA into PLGA NPs. Furthermore, PLGA NPs containing both cisplatin cores and RAPA induced significant apoptosis on A375-luc human melanoma cells in vitro. Additionally, they inhibited the growth of A375-luc melanoma in a xenograft tumor model through modulation of the tumor vasculature and permitted enhanced penetration of NPs into the tumor.
Additional file 1 of Building resilience in German primary care practices: a qualitative study
Creators: name: Litke, Nicola
name: Weis, Aline
name: Koetsenruijter, Jan
name: Fehrer, Valeska
name: Koeppen, Martina
name: Kuemmel, Stephanie
name: Szecsenyi, Joachim
name: Wensing, Michel
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Guide for focus groups.
title: Image-guided lung tumor ablation: a practical guide for imaging evaluation
Creators: name: Odisio, Erika
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Lung
subject: CT
subject: PET-CT
subject: Ablation procedures
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Succinctly describe percutaneous lung ablation modalities (thermal vs nonthermal), indications, technical aspects and limitations of the procedure. Discuss and illustrate computed tomography (CT) findings of involution of the ablation zone (AZ) post...
Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s
Creators: name: Schulz, Anita
name: Han, Yingchao
name: Di, Zhenyu
name: Wegener, Erik
name: Schubel, Rene
name: Jaksch, Sebastian
name: Kabanov, Alexander V.
name: Papadakis, Christine M.
name: Kressler, Jörg
name: Meister, Annette
name: Luxenhofer, Robert
name: Jordan, Rainer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Defined aggregates of polymers such as polymeric micelles are of great importance in the development of pharmaceutical formulations. The amount of drug that can be formulated by a drug delivery system is an important issue, and most drug delivery systems suffer from their relatively low drug-loading capacity. However, as the loading capacities increase, i.e., promoted by good drug–polymer interactions, the drug may affect the morphology and stability of the micellar system. We investigated this effect in a prominent system with very high capacity for hydrophobic drugs and found extraordinary stability as well as a profound morphology change upon incorporation of paclitaxel into micelles of amphiphilic ABA poly(2-oxazoline) triblock copolymers. The hydrophilic blocks A comprised poly(2-methyl-2-oxazoline), while the middle blocks B were either just barely hydrophobic poly(2-n-butyl-2-oxazoline) or highly hydrophobic poly(2-n-nonyl-2-oxazoline). The aggregation behavior of both polymers and their formulations with varying paclitaxel contents were investigated by means of dynamic light scattering, atomic force microscopy, (cryogenic) transmission electron microscopy, and small-angle neutron scattering. While without drug, wormlike micelles were present, after incorporation of small amounts of drugs only spherical morphologies remained. Furthermore, the much more hydrophobic poly(2-n-nonyl-2-oxazoline)-containing triblock copolymer exhibited only half the capacity for paclitaxel than the poly(2-n-butyl-2-oxazoline)-containing copolymer along with a lower stability. In the latter, contents of paclitaxel of 8 wt % or higher resulted in a raspberry-like micellar core.
Forecasting Internally Displaced Population Migration Patterns in Syria and Yemen
Creators: name: Huynh, Benjamin Q.
name: Basu, Sanjay
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applications (stat.AP)
subject: Physics and Society (physics.soc-ph)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Armed conflict has led to an unprecedented number of internally displaced persons (IDPs) - individuals who are forced out of their homes but remain within their country. IDPs often urgently require shelter, food, and healthcare, yet prediction of when large fluxes of IDPs will cross into an area remains a major challenge for aid delivery organizations. Accurate forecasting of IDP migration would empower humanitarian aid groups to more effectively allocate resources during conflicts. We show that monthly flow of IDPs from province to province in both Syria and Yemen can be accurately forecasted one month in advance, using publicly available data. We model monthly IDP flow using data on food price, fuel price, wage, geospatial, and news data. We find that machine learning approaches can more accurately forecast migration trends than baseline persistence models. Our findings thus potentially enable proactive aid allocation for IDPs in anticipation of forecasted arrivals.
title: Imaging of large bowel obstruction: etiology, complications and pitfalls
Creators: name: GÓMEZ VARELA, CRISTINA
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Colon
subject: CT
subject: Conventional radiography
subject: Education
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the role of imaging in the diagnosis of large bowel obstruction, reviewing the main radiological findings in multidetector computer tomography (MDCT) and abdominal radiography. To illustrate the main etiologies, complications and...
Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment
Creators: name: Huang, Leaf
name: Wang, Yuhua
name: Zhang, Lu
name: Xu, Zhenghong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Achievement of potent immunoresponses against self/tumor antigens and effective therapeutic outcome against advanced tumors remain major challenges in cancer immunotherapy. The specificity and efficiency of two nanoparticle-based delivery systems, lipid-calcium-phosphate (LCP) nanoparticle (NP) and liposome-protamine-hyaluronic acid (LPH) NP, provide us an opportunity to address both challenges. A mannose-modified LCP NP delivered both tumor antigen (Trp 2 peptide) and adjuvant (CpG oligonucleotide) to the dendritic cells and elicited a potent, systemic immune response regardless of the existence or the stage of tumors in the host. This vaccine was less effective, however, against later stage B16F10 melanoma in a subcutaneous syngeneic model. Mechanistic follow-up studies suggest that elevated levels of immune-suppressive cytokines within the tumor microenvironment, such as TGF-β, might be responsible. We strategically augment the efficacy of LCP vaccine on an advanced tumor by silencing TGF-β in tumor cells. The delivery of siRNA using LPH NP resulted in about 50% knockdown of TGF-β in the late stage tumor microenvironment. TGF-β down-regulation boosted the vaccine efficacy and inhibited tumor growth by 52% compared with vaccine treatment alone, as a result of increased levels of tumor infiltrating CD8+ T cells and decreased level of regulatory T cells. Combination of systemic induction of antigen-specific immune response with LCP vaccine and targeted modification of tumor microenvironment with LPH NP offers a flexible and powerful platform for both mechanism study and immunotherapeutic strategy development.
Additional file 2 of Building resilience in German primary care practices: a qualitative study
Creators: name: Litke, Nicola
name: Weis, Aline
name: Koetsenruijter, Jan
name: Fehrer, Valeska
name: Koeppen, Martina
name: Kuemmel, Stephanie
name: Szecsenyi, Joachim
name: Wensing, Michel
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Guide for interviews with other stakeholders.
(101208) William George Eaton Evans
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantum transport in d-dimensional lattices
Creators: name: Manzano, Daniel
name: Chuang, Chern
name: Cao, Jianshu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We prove analytically that both fermionic and bosonic uniform d-dimensional lattices can be reduced to a set of independent one-dimensional modes. This reduction leads to the conclusion that the dynamics in uniform fermionic and bosonic lattices is always ballistic. By the use of the Jordan-Wigner transformation we extend our analysis to spin lattices, proving the existence of both ballistic and non-ballistic subspaces in any dimension and for any system size. We then relate the nature of transport with the number of excitations in the spin lattice, indicating that a single excitation propagates always ballistically and that the non-ballistic behavior of uniform spin lattices is a consequence of the interaction between different excitations.
description: 13 pages, 5 figures
Accelerating the Translation of Nanomaterials in Biomedicine
Creators: name: Kataoka, Kazunori
name: Kabanov, Alexander V.
name: Venkatraman, Subbu S.
name: Xia, Younan
name: Stevens, Molly M.
name: Gu, Zhen
name: Ho, Dean
name: Karp, Jeffrey M.
name: Chen, Xiaoyuan
name: Mirkin, Chad A.
name: Wang, Shutao
name: Chow, Edward K.
name: Shi, Jinjun
name: Xu, Chenjie
name: Mitragotri, Samir
name: Sun, Shouheng
name: Petrosko, Sarah Hurst
name: Teoh, Sweehin
name: Anderson, Daniel G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Due to their size and tailorable physicochemical properties, nanomaterials are an emerging class of structures utilized in biomedical applications. There are now many prominent examples of nanomaterials being used to improve human health, in areas ranging from imaging and diagnostics to therapeutics and regenerative medicine. An overview of these examples reveals several common areas of synergy and future challenges. This Nano Focus discusses the current status and future potential of promising nanomaterials and their translation from the laboratory to the clinic, by highlighting a handful of successful examples.
title: Ultrasound-Guided Vacuum-Assisted Percutaneous Benign Breast Lesion Removal Success and Failure Explained by the Use of a Generalized Linear Model
Creators: name: Dyer Hartnett, Shelagh
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Pathology
subject: Neoplasia
subject: Vacuum assisted biopsy
subject: Ultrasound
subject: Percutaneous
subject: Interventional non-vascular
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate the efficacy of benign breast lesion removal by ultrasound-guided vacuum-assisted percutaneous excision (US-VAAB) in our tertiary centre; To compare lesion volume calculated by US against total tissue volume excised measured by an...
Additional file 1 of Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry
Creators: name: Romiti, Giulio Francesco
name: Proietti, Marco
name: Vitolo, Marco
name: Bonini, Niccolò
name: Fawzy, Ameenathul Mazaya
name: Ding, Wern Yew
name: Fauchier, Laurent
name: Marin, Francisco
name: Nabauer, Michael
name: Dan, Gheorghe Andrei
name: Potpara, Tatjana S.
name: Boriani, Giuseppe
name: Lip, Gregory Y. H.
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Items Included into the Frailty Index. Table S2. Baseline Characteristics of the Cohort. Table S3. Cox Regression for the risk of major outcomes according to clinical complexity and subgroups. Table S4. Baseline characteristics according to cluster allocation. Figure S1. Kaplan Meier Curves for the risk of MACE according to cluster analysis. Figure S2. Kaplan Meier Curves for the risk of composite outcome according to cluster analysis. Figure S3. Delay of Event analysis for MACE, ABC adherent vs. non-adherent in cluster 1 subgroup. Figure S4. Delay of Event analysis for Composite Outcome, ABC adherent vs. non-adherent in cluster 1 subgroup.
Bounded limit cycles of polynomial foliations of $\mathbb CP^2$
Creators: name: Goncharuk, Nataliya
name: Kudryashov, Yury
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: In this article we prove in a new way that a generic polynomial vector field in $\mathbb C^2$ possesses countably many homologically independent limit cycles. The new proof needs no estimates on integrals, provides thinner exceptional set for quadratic vector fields, and provides limit cycles that stay in a bounded domain.
Vacuum currents in braneworlds on AdS bulk with compact dimensions
Creators: name: Bellucci, S.
name: Saharian, A. A.
name: Vardanyan, V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The two-point function and VEV of the current density are investigated for a massive charged scalar field with arbitrary curvature coupling in the geometry of a brane on background of AdS spacetime with partial toroidal compactification.The presence of a gauge field flux enclosed by compact dimensions is assumed.On the brane the field obeys Robin boundary condition and along compact dimensions periodicity conditions with general phases are imposed.There is a range in the space of values for the coefficient in the boundary condition where Poincare vacuum is unstable.This range depends on the brane location.In models with compact dimensions the stability condition is less restrictive than for AdS bulk with trivial topology.Vacuum charge density and components of current along non-compact dimensions vanish. VEV of the current density along compact dimensions is a periodic function of the gauge field flux with a period equal to the flux quantum.It is decomposed into the boundary-free and brane-induced contributions.The asymptotic behavior of the latter is investigated near the brane, AdS boundary and horizon.In contrast to VEVs of the field squared and energy-momentum tensor, current density is finite on brane and vanishes for the special case of Dirichlet boundary condition.Both boundary-free and brane-induced contributions vanish on AdS boundary.Brane-induced contribution vanishes on the horizon and for points near the horizon the current is dominated by the boundary-free part.In the near-horizon limit, the latter is connected to the corresponding quantity for a massless field in the Minkowski bulk by a simple conformal relation.Depending on the value of the Robin coefficient, the presence of the brane can either increase or decrease the vacuum currents. Applications are given for a higher-dimensional version of the Randall-Sundrum 1-brane model
description: 30 pages, 8 figures, PACS numbers: 04.62.+v, 04.50.-h, 11.10.Kk, 11.25.-w
Fast Algorithms for Rank-1 Bimatrix Games
Creators: name: Adsul, Bharat
name: Garg, Jugal
name: Mehta, Ruta
name: Sohoni, Milind
name: von Stengel, Bernhard
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: The rank of a bimatrix game is the matrix rank of the sum of the two payoff matrices. This paper comprehensively analyzes games of rank one, and shows the following: (1) For a game of rank r, the set of its Nash equilibria is the intersection of a generically one-dimensional set of equilibria of parameterized games of rank r-1 with a hyperplane. (2) One equilibrium of a rank-1 game can be found in polynomial time. (3) All equilibria of a rank-1 game can be found by following a piecewise linear path. In contrast, such a path-following method finds only one equilibrium of a bimatrix game. (4) The number of equilibria of a rank-1 game may be exponential. (5) There is a homeomorphism between the space of bimatrix games and their equilibrium correspondence that preserves rank. It is a variation of the homeomorphism used for the concept of strategic stability of an equilibrium component.
description: New in v4: detailed comparison with Theobald (2009) on page 6. Footnotes removed. Final version accepted by OPERATIONS RESEARCH
title: MDCT evaluation of esophageal pathology: what to look for
Creators: name: Amorim, João
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Trauma
subject: Cancer
subject: Acute
subject: Diagnostic procedure
subject: CT
subject: Thorax
subject: Stomach (incl. Oesophagus)
subject: Gastrointestinal tract

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Discuss the usefulness and limitations of MDCT in the evaluation of esophageal disease, particularly in the emergency setting; Describe normal findings and variations in esophagus imaging appearance in MDCT; Illustrate the main imaging features of...
Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles
Creators: name: Wang, Andrew Z.
name: Au, Kin Man
name: Perello, Virginia
name: Tian, Xi
name: Min, Yuanzeng
name: Caster, Joseph M.
name: Zhang, Longzhen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Combining molecularly targeted agents and chemotherapeutics is an emerging strategy in cancer treatment. We engineered sub-50 nm diameter diblock copolymer nanoparticles (NPs) that can sequentially release wortmannin (Wtmn, a cell signaling inhibitor) and docetaxel (Dtxl, genotoxic anticancer agent) to cancer cells. These NPs were studied in chemoradiotherapy, an important cancer treatment paradigm, in the preclinical setting. We demonstrated that Wtmn enhanced the therapeutic efficacy of Dtxl and increased the efficiency of radiotherapy (XRT) in H460 lung cancer and PC3 prostate cells in culture. Importantly, we showed that NPs containing both Wtmn and Dtxl release the drugs in a desirable sequential fashion to maximize therapeutic efficacy in comparison to administering each drug alone. An in vivo toxicity study in a murine model validated that NPs containing both Dtxl and Wtmn do not have a high toxicity profile. Lastly, we demonstrated that Dtxl/Wtmn-coencapsulated NPs are more efficient than each sin...
Inside the tent
Creators: name: Aitchison, Kenneth
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 430205
subject: Heritage and cultural conservation

description: short article reviewing Icon, the Institute of Conservation's achievements and opportunities
Aitchison, K. 2014. “Inside the tent”, ICON News 51, 10.https://www.icon.org.uk/resource/icon-news-51-march-2014-pdf.html
(101206) Thomas Reid Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On the nature of transverse coronal waves revealed by wavefront dislocations
Creators: name: Ariste, A. López
name: Luna, M.
name: Arregui, I.
name: Khomenko, E.
name: Collados, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Coronal waves are an important aspect of the dynamics of the plasma in the corona. Wavefront dislocations are topological features of most waves in nature and also of magnetohydrodynamic waves. Are there dislocations in coronal waves? The finding and explanation of dislocations may shed light on the nature and characteristics of the propagating waves, their interaction in the corona and in general on the plasma dynamics. We positively identify dislocations in coronal waves observed by the Coronal Multi-channel Polarimeter (CoMP) as singularities in the Doppler shifts of emission coronal lines. We study the possible singularities that can be expected in coronal waves and try to reproduce the observed dislocations in terms of localization and frequency of appearance. The observed dislocations can only be explained by the interference of a kink and a sausage wave modes propagating with different frequencies along the coronal magnetic field. In the plane transverse to the propagation, the cross-section of the oscillating plasma must be smaller than the spatial resolution, and the two waves result in net longitudinal and transverse velocity components that are mixed through projection onto the line of sight. Alfvén waves can be responsible of the kink mode, but a magnetoacoustic sausage mode is necessary in all cases. Higher (flute) modes are excluded. The kink mode has a pressure amplitude that is smaller than the pressure amplitude of the sausage mode, though its observed velocity is larger. This concentrates dislocations on the top of the loop. To explain dislocations, any model of coronal waves must include the simultaneous propagation and interference of kink and sausage wave modes of comparable but different frequencies, with a sausage wave amplitude much smaller than the kink one.
description: 11 pages. 5 figures. Accepted for publication in A&A
Additional file 3 of Building resilience in German primary care practices: a qualitative study
Creators: name: Litke, Nicola
name: Weis, Aline
name: Koetsenruijter, Jan
name: Fehrer, Valeska
name: Koeppen, Martina
name: Kuemmel, Stephanie
name: Szecsenyi, Joachim
name: Wensing, Michel
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Guide for interviews with practice staff.
Manipulation of Endogenous Kinase Activity in Living Cells Using Photoswitchable Inhibitory Peptides
Creators: name: Danuser, Gaudenz
name: Wang, Hui
name: Vilela, Marco
name: Yi, Jason J.
name: Hahn, Klaus M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Optogenetic control of endogenous signaling can be an important tool for probing cell behavior. Using the photoresponse of the LOV2 domain of Avena sativa phototropin 1, we developed analogues of kinase inhibitors whose activity is light dependent. Inhibitory peptides were appended to the Jα helix, where they potently inhibited kinases in the light but were sterically blocked from kinase interaction in the dark. Photoactivatable inhibitors for cyclic-AMP dependent kinase (PKA) and myosin light chain kinase (MLCK) are described, together with studies that shed light on proper positioning of the peptides in the LOV domain. These inhibitors altered endogenous signaling in living cells and produced light-dependent changes in cell morphodynamics.
Morphological analysis of the antimicrobial action of nitric oxide on Gram-negative pathogens using atomic force microscopy
Creators: name: Deupree, Susan M.
name: Schoenfisch, Mark H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Atomic force microscopy (AFM) was used to study the morphological changes of two Gram-negative pathogens, Pseudomonas aeruginosa and Escherichia coli, after exposure to nitric oxide (NO). The time-dependent effects of NO released from a xerogel coating and the concentration-dependent effects rendered by a small-molecule that releases NO in a bolus were examined and compared. Bacteria exhibited irregular and degraded exteriors. With NO-releasing surfaces, an increase in surface debris and disorganized adhesion patterns were observed compared to controls. Analysis of cell surface topography revealed that increasing membrane roughness correlated with higher doses of NO. At a lower total dose, NO delivered via a bolus resulted in greater membrane roughness than NO released from a surface via a sustained flux. At sub-inhibitory levels, treatment with amoxicillin, an antibiotic known to compromise the integrity of the cell wall, led to morphologies resembling those resulting from NO treatment. Our observations indicate that cell envelope deterioration is a visible consequence of NO-exposure for both Gram-negative species studied.
(101202) Yarnold Hubert Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence.
Creators: name: Ragnhildstveit, Anya
name: Roscoe, Jeremy
name: Bass, Lisa C
name: Averill, Christopher L
name: Abdallah, Chadi G
name: Averill, Lynnette A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: clinical evidence
esketamine
ketamine
pharmacotherapy
posttraumatic stress disorder (PTSD)
rapid-acting antidepressant (RAAD)
treatment

description: Peer reviewed: True
description: Posttraumatic stress disorder (PTSD) is a devastating condition, for which there are few pharmacological agents, often with a delayed onset of action and poor efficacy. Trauma-focused psychotherapies are further limited by few trained providers and low patient engagement. This frequently results in disease chronicity as well as psychiatric and medical comorbidity, with considerable negative impact on quality of life. As such, off-label interventions are commonly used for PTSD, particularly in chronic refractory cases. Ketamine, an N-methyl-D-aspartate (NDMA) receptor antagonist, has recently been indicated for major depression, exhibiting rapid and robust antidepressant effects. It also shows transdiagnostic potential for an array of psychiatric disorders. Here, we synthesize clinical evidence on ketamine in PTSD, spanning case reports, chart reviews, open-label studies, and randomized trials. Overall, there is high heterogeneity in clinical presentation and pharmacological approach, yet encouraging signals of therapeutic safety, efficacy, and durability. Avenues for future research are discussed.
title: MDCT evaluation of aortic aneurysms: common and uncommon findings
Creators: name: Amorim, João
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Arteries / Aorta
subject: CT
subject: CT-Angiography
subject: Diagnostic procedure
subject: Aneurysms

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Describe common imaging findings in thoracic and abdominal aortic aneurysms; Review uncommon cases including infected aortic aneurysms, aortoenteric fistulas and other...
Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery
Creators: name: Kim, Won Jong
name: Son, Sejin
name: Repka, Michael A.
name: Jo, Seongbong
name: Kim, Jin Ki
name: Garripelli, Vivek Kumar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Development of a successful bioresponsive drug delivery system requires exquisite engineering of materials so that they are able to respond to the signals stemming from the physiological environment. In this study, we proposed a new Pluronic® based thermogelling system containing matrix metalloproteinase-2 (MMP2) responsive peptide sequences. A novel thermosensitive multiblock copolymer comprising an MMP2-labile octapeptide (Gly-Pro-Val-Gly-Leu-Ile-Gly-Lys) was synthesized from Pluronic® triblock copolymer. The polymer was designed to form thermogel at body temperature and degrade in presence of MMP overexpressed in the tumor. The synthesized polymer was a multiblock copolymer with ~ 2.5 units of Pluronic®. The multiblock copolymer solutions exhibited a reverse thermal gelation around body temperature. The gelation temperatures of the multiblock copolymer solutions were lower than those of the corresponding Pluronic® monomer at a particular concentration. The cytotoxicity of the synthesized polymer was lower comparing to its monomer. The solubility of hydrophobic anticancer drug, paclitaxel, was enhanced in the polymer solutions via micelle formation. The synthesized polymer was preferentially degraded in presence of MMP. Paclitaxel release was dependent on the enzyme concentration. These findings suggest that the synthesized polymer has the potential as controlled drug delivery system due to its unique phase transition and bioresponsive behavior.
Additional file 1 of Therapeutic potential of conditioned medium obtained from deferoxamine preconditioned umbilical cord mesenchymal stem cells on diabetic nephropathy model
Creators: name: Ozkan, Serbay
name: Isildar, Basak
name: Ercin, Merve
name: Gezginci-Oktayoglu, Selda
name: Konukoglu, Dildar
name: Neşetoğlu, Neşet
name: Oncul, Mahmut
name: Koyuturk, Meral
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Additional file 1: S1: Sample preparation for light microscopy. S2: Sample preparation for transmission electron microscopy.
Three-dimensional laser micro- and nano-structuring of acrylated poly(ethylene glycol) materials and evaluation of their cytoxicity for tissue engineering applications
Creators: name: Sternberg, K.
name: Chichkov, B.
name: Gittard, S.
name: Löbler, M.
name: Haverich, A.
name: Malinauskas, M.
name: Schmitz, K. P.
name: Schlie, S.
name: Ovsianikov, A.
name: Narayan, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The natural cell environment is characterised by complex three-dimensional structures, which contain features at multiple length scales. Many in vitro studies of cell behaviour in three dimensions rely on the availability of artificial scaffolds with controlled three-dimensional topologies. In this paper, we demonstrate fabrication of three-dimensional scaffolds for tissue engineering out of poly(ethylene glycol) diacrylate (PEGda) materials by means of two-photon polymerization (2PP). This laser nanostructuring approach offers unique possibilities for rapid manufacturing of three-dimensional structures with arbitrary geometries. The spatial resolution dependence on the applied irradiation parameters is investigated for two PEGda formulations, which are characterized by molecular weights of 302 and 742. We demonstrate that minimum feature sizes of 200 nm are obtained in both materials. In addition, an extensive study of the cytotoxicity of the material formulations with respect to photoinitiator type and photoinitiator concentration is undertaken. Aqueous extracts from photopolymerized PEGda samples indicate the presence of water-soluble molecules, which are toxic to fibroblasts. It is shown that sample aging in aqueous medium reduces the cytotoxicity of these extracts; this mechanism provides a route for biomedical applications of structures generated by 2PP microfabrication and photopolymerization technologies in general. Finally, a fully biocompatible combination of PEGda and a photoinitiator is identified. Fabrication of reproducible scaffold structures is very important for systematic investigation of cellular processes in three dimensions and for better understanding of in vitro tissue formation. The results of this work suggest that 2PP may be used to polymerize poly(ethylene glycol)-based materials into three-dimensional structures with well-defined geometries that mimic the physical and biological properties of native cell environments.
Dendritic nanoconjugates of photosensitizer for targeted photodynamic therapy
Creators: name: Yang, Bing
name: Hu, Yiqiao
name: Ming, Xin
name: Wu, Jinhui
name: Yuan, Ahu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Abstract Application of photodynamic therapy for treating cancers has been restrained by suboptimal delivery of photosensitizers to cancer cells. Nanoparticle (NP)-based delivery has become an important strategy to improve tumor delivery of photosensitizers; however, the success is still limited. One problem for many NPs is poor penetration into tumors, and thus the photokilling is not complete. We aimed to use chemical conjugation method to engineer small NPs for superior cancer cell uptake and tumor penetration. Thus, Chlorin e6 (Ce6) was covalently conjugated to PAMAM dendrimer (generation 7.0) that was also modified by tumor-targeting RGD peptide. With multiple Ce6 molecules in a single nanoconjugate molecule, the resultant targeted nanoconjugates showed uniform and monodispersed size distribution with a diameter of 28 nm. The singlet oxygen generation efficiency and fluorescence intensity of the nanoconjugates in aqueous media were significantly higher than free Ce6. Targeted nanoconjugates demonstrated approximately 16-fold enhancement in receptor-specific cellular delivery of Ce6 into integrin-expressing A375 cells compared to free Ce6 and thus were able to cause massive cell killing at low nanomolar concentrations under photo-irradiation. In contrast, they did not cause significant toxicity up to 2 μM in dark. Due to their small size, the targeted nanoconjugates could penetrate deeply into tumor spheroids and produced strong photo-toxicity in this 3-D tumor model. As a result of their great cellular delivery, small size, and lack of dark cytotoxicity, the nanoconjugates may provide an effective tool for targeted photodynamic therapy of solid tumors. Graphical abstract
MPEC 2024-R187 : 2024 RM7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RM7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: X-ray differentials of the knee region - a pictorial review of calcified masses, lytic lesions, fractures and posttraumatic alterations
Creators: name: Lanczi , Levente István
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal system
subject: Conventional radiography
subject: MR
subject: CT
subject: Diagnostic procedure
subject: Normal variants
subject: Education
subject: Arthritides
subject: Calcifications / Calculi
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Intra- and extraosseous calcified masses are quite common in the knee region on plain film: osteophytes, osteochondroma, ostechondritis, fabellae, loose bodies, bipartite patella, bone infarct, neoplasms, avulsion fractures or other traumatic...
Bisimulation and expressivity for conditional belief, degrees of belief, and safe belief
Creators: name: Andersen, Mikkel Birkegaard
name: Bolander, Thomas
name: van Ditmarsch, Hans
name: Jensen, Martin Holm
Publisher: name: arXiv
Year: 2015
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: Plausibility models are Kripke models that agents use to reason about knowledge and belief, both of themselves and of each other. Such models are used to interpret the notions of conditional belief, degrees of belief, and safe belief. The logic of conditional belief contains that modality and also the knowledge modality, and similarly for the logic of degrees of belief and the logic of safe belief. With respect to these logics, plausibility models may contain too much information. A proper notion of bisimulation is required that characterises them. We define that notion of bisimulation and prove the required characterisations: on the class of image-finite and preimage-finite models (with respect to the plausibility relation), two pointed Kripke models are modally equivalent in either of the three logics, if and only if they are bisimilar. As a result, the information content of such a model can be similarly expressed in the logic of conditional belief, or the logic of degrees of belief, or that of safe belief. This, we found a surprising result. Still, that does not mean that the logics are equally expressive: the logics of conditional and degrees of belief are incomparable, the logics of degrees of belief and safe belief are incomparable, while the logic of safe belief is more expressive than the logic of conditional belief. In view of the result on bisimulation characterisation, this is an equally surprising result. We hope our insights may contribute to the growing community of formal epistemology and on the relation between qualitative and quantitative modelling.
(101203) Alice Gertrude Martin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Automatic Three-Dimensional Cephalometric Annotation System Using Three-Dimensional Convolutional Neural Networks
Creators: name: Kang, Sung Ho
name: Jeon, Kiwan
name: Kim, Hak-Jin
name: Seo, Jin Keun
name: Lee, Sang-Hwy
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Background: Three-dimensional (3D) cephalometric analysis using computerized tomography data has been rapidly adopted for dysmorphosis and anthropometry. Several different approaches to automatic 3D annotation have been proposed to overcome the limitations of traditional cephalometry. The purpose of this study was to evaluate the accuracy of our newly-developed system using a deep learning algorithm for automatic 3D cephalometric annotation. Methods: To overcome current technical limitations, some measures were developed to directly annotate 3D human skull data. Our deep learning-based model system mainly consisted of a 3D convolutional neural network and image data resampling. Results: The discrepancies between the referenced and predicted coordinate values in three axes and in 3D distance were calculated to evaluate system accuracy. Our new model system yielded prediction errors of 3.26, 3.18, and 4.81 mm (for three axes) and 7.61 mm (for 3D). Moreover, there was no difference among the landmarks of the three groups, including the midsagittal plane, horizontal plane, and mandible (p>0.05). Conclusion: A new 3D convolutional neural network-based automatic annotation system for 3D cephalometry was developed. The strategies used to implement the system were detailed and measurement results were evaluated for accuracy. Further development of this system is planned for full clinical application of automatic 3D cephalometric annotation.