Synergistic effects of herbal medicines and anticancer drugs: A protocol for systematic review and meta analysis
Creators: name: Cheon, Chunhoo
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Neoplasms
subject: Alternative and Complementary Medicine
subject: Diseases
subject: Medicine and Health Sciences

description: 1. Review title. Synergistic effects of herbal medicines and anticancer drugs: A protocol for systematic review and meta analysis 2. Anticipated or actual start date. 01/10/2021 3. Anticipated completion date. 31/03/2022 4. Stage of review at time of this submission. Preliminary searches: No Started Piloting of the study selection process: No Started Formal screening of search results against eligibility criteria: No Started Data extraction: No Started Risk of bias (quality) assessment: No Started Data analysis: No Started 5. Named contact. Chunhoo Cheon 6. Named contact email. hreedom@khu.ac.kr 7. Named contact address Department of Preventive medicine, Korean medicine College, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea 8. Named contact phone number. +822-961-2382 9. Organisational affiliation of the review. Kyung Hee University Korean Medicine-Based Drug Repositioning Cancer Research Center http://kdcrc.kr 10. Review team members and their organisational affiliations. Dr Chunhoo Cheon. Kyung Hee University 11. Funding sources/sponsors. This research was supported by a grant of the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A5A2019413) and the Korea Health Technology R&amp;D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &amp; Welfare, Republic of Korea (grant number: HI18C2382). 12. Conflicts of interest. None 13. Collaborators. None 14. Review question. Which herbal medicines show a synergistic effect when combined with anticancer drugs? 15. Searches. The following electronic databases will be searched: PubMed, EMBASE, Cochrane Library, Korean databases and Chinese databases. The search terms will be the MeSH terms of ' Antineoplastic Agents', 'Phytotherapy', and 'Drug Synergism'. 16. Condition or domain being studied. Cancer 17. Participants/population. Patient with cancer or cancer model 18. Intervention(s), exposure(s). Herbal medicine combined with anticancer drug 19. Comparator(s)/control. No specific restriction 20. Types of study to be included. no restriction 21. Main outcome(s). Synergistic effect of herbal medicine and anticancer drug 22. Additional outcome(s). None 23. Data extraction (selection and coding). Two independent researchers will review all articles and extract the data using a standard data extraction form. Any disagreement between the authors will be resolved by discussion or third party arbitration. 24. Risk of bias (quality) assessment. RoB 2 tool (revised tool for Risk of Bias in randomized trials) will be used to assess risk of bias of randomized controlled trials. 25. Strategy for data synthesis. The data will be narratively synthesized. 26. Analysis of subgroups or subsets. Subgroup analysis will be conducted according to the herbal medicine and anticancer drug. 27. Type and method of review. Type of review- Intervention, Narrative synthesis Health area of the review-Complementary therapies 28. Language. English 29. Country. South Korea 30. Dissemination plans. Do you intend to publish the review on completion? Yes 31. Current review status. Ongoing