cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Pursuit of Utopia on a Spectrum from Nature to Technology
Creators: name: Drotleff, Oliver
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 500317
subject: Philosophy of science (excl. history and philosophy of specific fields)

description: Written from an engineer’s perspective, this philosophical paper is intended to be a manifest of a holistic perspective on progress. Given that utopia in its description of an ideal state cannot refer to an isolated technology or field of science, and always implies an interconnected system of flawless components, it would make sense to frame the discussion about it in an interdisciplinary manner. The goal, therefore, is to cover as many different topics, aspects, and thoughts about the subject in question, without venturing into too much detail, as the depth of the discussion would limit the width that the chosen topic has the potential for. While undoubtedly losing some nuance in the abstraction of scientific fields, it is seen as a necessary and calculated compromise to rely on the concept of thin-slicing, representative segments to approximate a comparative quality of description, while also targeting a much larger demographic. In academia, this is an approach that is arguably both rare and underrated and this thesis is trying to add to the compensation of this discrepancy. In order to be accessible to as many disciplines as possible, complex developments will be broken down into simple concepts, so that their analysis can ensue in layman’s terms and the essence of the scientific principle can be expanded to allow for philosophical interpretation. Engineering, in a broad way, acts as the gateway that connects all theoretical sciences with the tangible world, and allows for the application of theoretical and empirical science with the goal of enhancing the quality of life in our society, and as this bottleneck of conceptualization, that all future inventions have to traverse. Thus, for the key position that it finds itself in, engineering is an essential step in impacting the direction of development humanity is taking, with utopia being the end destination a long way down the road of that chosen direction. And as the tool that has the capability to create all things people consume, naturally this decision of what to make, and what not to, has to be linked to an ethical component, that in and of itself can be best judged when looking at the bigger picture. It is an existential assessment, based on philosophical, but also technical, psychological as well as socio-economic implications, and precisely this is what the thesis is intended to give an overview for.
Towards a Categorical Representation of Reversible Event Structures
Creators: name: Graversen, Eva
name: Phillips, Iain
name: Yoshida, Nobuko
Publisher: name: arXiv
Year: 2017
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We study categories for reversible computing, focussing on reversible forms of event structures. Event structures are a well-established model of true concurrency. There exist a number of forms of event structures, including prime event structures, asymmetric event structures, and general event structures. More recently, reversible forms of these types of event structures have been defined. We formulate corresponding categories and functors between them. We show that products and co-products exist in many cases. In most work on reversible computing, including reversible process calculi, a cause-respecting condition is posited, meaning that the cause of an event may not be reversed before the event itself. Since reversible event structures are not assumed to be cause-respecting in general, we also define cause-respecting subcategories of these event structures. Our longer-term aim is to formulate event structure semantics for reversible process calculi.
description: In Proceedings PLACES 2017, arXiv:1704.02418
Hand gesture controlled robotic arm
Creators: name: Riley, Solomon
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Over the years robots have been designed to perform various tasks much quicker and more effiently than humans. Though these robots may be fast and capable, controlling them can be slow and cumbersome. Hand gesture control is an emerging method of controlling robots in a simplified and more efficient manner. Using hand gesture control over other control options is beneficial as it incorporates natural human movement to achieve the same or even more control in an uncomplicated fashion. The project seeks to develop a cheap and simple method of hand gesture control for a robotic arm with five degrees of freedom (DOF). The proposed method is a glove fitted with various sensors that will interpret hand gestures, process them and control the robot. A flex sensor, two accelerometers, and a gyroscope will be attached to the glove to achieve this control. The result is a cheap and simple prototype that has full control over the 5 DOF of the robotic arm. The concepts of this project can be applied to many areas of industry, with possibilities such as military applications, medical procedures, or even handling hazardous waste such as nuclear etc.
title: ADCO, Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Cart. 21 (G 125), 71 folios, f. 00007
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00007, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00007, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Protein and hydration-water dynamics are decoupled: A new model connecting dynamics and biochemical function is required
Creators: name: Benedetto, Antonio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Water plays a major role in bio-systems, greatly contributing to determine their structure, stability and even function. It is well know, for instance, that proteins require a minimum amount of water to be functionally active. Since the biological functions of proteins involve changes of conformation, and sometimes chemical reactions, it is natural to expect a connection of these functions with dynamical properties of the coupled system of proteins and their hydration water. However, despite many years of intensive research, the detailed nature of protein - hydration water interactions, and their effect on the biochemical activity of proteins through peculiar dynamical effects, is still partly unknown. In particular, models proposed so far, fail to explain the full set of experimental data. The well-accepted 'protein dynamical transition' scenario is based on perfect coupling between the dynamics of proteins and of their hydration water, which has never been confuted experimentally. We present high-energy resolution elastic neutron scattering measurements of the atomistic dynamics of the model protein, lysozyme, in water that were carried out on the IN16B spectrometer at the Institut Laue-Langevin in Grenoble, France. These show for the first time that the dynamics of proteins and of their hydration water are actually de-coupled. This important result militates against the well-accepted scenario, and requires a new model to link protein dynamics to the dynamics of its hydration water, and, in turn, to biochemical function.
description: 8 pages, 3 figures, new results
Inequalities for the modified Bessel function of the second kind and the kernel of the Krätzel integral transformation
Creators: name: Gaunt, Robert E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33C10

description: We obtain new inequalities for the modified Bessel function of the second kind $K_ν$ in terms of the gamma function. These bounds follow as special cases of inequalities that we derive for the kernel of the Krätzel integral transformation.
description: 4 pages, to appear in Mathematical Inequalities and Applications, 2017+
Additional file 2: Figure S2. of Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells
Creators: name: Pietrosemoli, Natalia
name: Mella, Sébastien
name: Yennek, Siham
name: Baghdadi, Meryem
name: Sakai, Hiroshi
name: Ramkumar Sambasivan
name: Pala, Francesca
name: Girolamo, Daniela Di
name: Shahragim Tajbakhsh
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Violin plots of the logFC distribution for each individual dataset. Density plots of the logFC (|logFC| 1 in blue. (PDF 156 kb)
Structural studies of RNase M5 reveal two-metal-ion supported two-step dsRNA cleavage for 5S rRNA maturation
Creators: name: Oerum, Stephanie
name: Catala, Marjorie
name: Bourguet, Maxime
name: Gilet, Laetitia
name: Barraud, Pierre
name: Cianférani, Sarah
name: Condon, Ciarán
name: Tisné, Carine
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: All species transcribe ribosomal RNA in an immature form that requires several enzymes for processing into mature rRNA. The number and types of enzymes utilized for these processes vary greatly between different species. In low G + C Gram-positive bacteria including Bacillus subtilis and Geobacillus stearothermophilus, the endoribonuclease (RNase) M5 performs the final step in 5S rRNA maturation, by removing the 3ʹ- and 5ʹ-extensions from precursor (pre) 5S rRNA. This cleavage activity requires initial complex formation between the pre-rRNA and a ribosomal protein, uL18, making the full M5 substrate a ribonucleoprotein particle (RNP). M5 contains a catalytic N-terminal Toprim domain and an RNA-binding C-terminal domain, respectively, shown to assist in processing and binding of the RNP. Here, we present structural data that show how two Mg2+ ions are accommodated in the active site pocket of the catalytic Toprim domain and investigate the importance of these ions for catalysis. We further perform solution studies that support the previously proposed 3ʹ-before-5ʹ order of removal of the pre-5S rRNA extensions and map the corresponding M5 structural rearrangements during catalysis.
Additional file 1 of Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson’s disease
Creators: name: Chen, Bing
name: Zhang, Qian
name: Zhong, Xiaoru
name: Zhang, Xinwei
name: Liu, Xin
name: Wang, Hongyang
name: Yang, Fan
name: Zhang, Jingjing
name: Huang, Jingnan
name: Wong, Yin-Kwan
name: Luo, Piao
name: Wang, Jigang
name: Sun, Jichao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Fig. S1. 1H NMR and 13C NMR of dopamine probe (DA-P). Fig. S2. CESTA and immunofluorescence to verify DA binding to PKM2 and aldolase A. A&B CETSA to verify DA binding to PKM2 or aldolase A. Cell lysates incubated with 100 µM DA for 2 h were subjected to CESTA-western blot analysis. C Representative fluorescence images of intracellular PKM2 in MN9D cells following labeling with 100 µM DA-P for 3 h. Error bars, mean ± s.d. Scale bar, 10 µm. *, p < 0.05. Fig. S3. DA suppresses the enzymatic activity of neuron α-enolase. A The immuno-blots showing the level of endogenous aldolase A after incubation with indicated concentrations of DA for 24 h. B Measurement of the catalytic activity of α-enolase extracted from cultured striatal neurons with the treatment of indicated concentrations of DA. C Measurement of the catalytic activity of α-enolase extracted from mouse midbrain tissue with the treatment of indicated concentrations of DA. Fig. S4. DA could bind to K230 residue of aldolase A, and Cys49 and Cys424 residues of PKM2. A-C In-gel fluorescence visualization of recombinant human aldolase A, α-enolase and PKM2 labeled by IAA-yne in the presence or absence of the competitors DA or IAA. D MS/MS spectrum of human aldolase A treated with 100 µM DA for 60 min. E A binding model of DA with human aldolase A predicted by molecular docking. F&G MS/MS spectrum of human PKM2 treated with 100 µM DA for 60 min. H A binding model of DA with human PKM2 predicted by molecular docking. Fig. S5. Metabolic dysfunction caused by DA via inducing mitochondrial damage. A-C Measurement of indicators of OCR rate in MN9D cells under different concentrations of DA (0, 100, 400 and 800 µM) treatment for 12 h. D Heatmap showing top up and down metabolites after 400 µM DA incubation for 12 h. E KEGG pathway enrichment analysis of DA-targeted metabolites. Top 25 pathways are shown. All error bars represent mean ± s.d. n.s. not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
Online and Offline Domain Adaptation for Reducing BCI Calibration Effort
Creators: name: Wu, Dongrui
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (cs.LG)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Many real-world brain-computer interface (BCI) applications rely on single-trial classification of event-related potentials (ERPs) in EEG signals. However, because different subjects have different neural responses to even the same stimulus, it is very difficult to build a generic ERP classifier whose parameters fit all subjects. The classifier needs to be calibrated for each individual subject, using some labeled subject-specific data. This paper proposes both online and offline weighted adaptation regularization (wAR) algorithms to reduce this calibration effort, i.e., to minimize the amount of labeled subject-specific EEG data required in BCI calibration, and hence to increase the utility of the BCI system. We demonstrate using a visually-evoked potential oddball task and three different EEG headsets that both online and offline wAR algorithms significantly outperform several other algorithms. Moreover, through source domain selection, we can reduce their computational cost by about 50%, making them more suitable for real-time applications.
description: in press
Description of turbulent dynamics in the interstellar medium: Multifractal microcanonical analysis: II. Sparse filtering of Herschel observation maps and visualization of filamentary structures at different length scales
Creators: name: Rashidi, A.
name: Yahia, H.
name: Bontemps, S.
name: Schneider, N.
name: Bonne, L.
name: Hennebelle, P.
name: Scholtys, J.
name: Attuel, G.
name: Turiel, A.
name: Simon, R.
name: Cailly, A.
name: Zebadua, A.
name: Cherif, A.
name: Lacroix, C.
name: Martin, M.
name: Aouni, A. El
name: Sakka, C.
name: Maji, S. K.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences
subject: 85-02

description: We present significant improvements to our previous work on noise reduction in {\sl Herschel} observation maps by defining sparse filtering tools capable of handling, in a unified formalism, a significantly improved noise reduction as well as a deconvolution in order to reduce effects introduced by the limited instrumental response (beam). We implement greater flexibility by allowing a wider choice of parsimonious priors in the noise-reduction process. More precisely, we introduce a sparse filtering and deconvolution approach approach of type $l^2$-$l^p$, with $p > 0$ variable and apply it to a larger set of molecular clouds using {\sl Herschel} 250 $μ$m data in order to demonstrate their wide range of application. In the {\sl Herschel} data, we are able to use this approach to highlight extremely fine filamentary structures and obtain singularity spectra that tend to show a significantly less $\log$-normal behavior and a filamentary nature in the less dense regions. We also use high-resolution adaptive magneto-hydrodynamic simulation data to assess the quality of deconvolution in such a simulated beaming framework.
description: 24 pages, 32 figures, official acceptance date on 16/05/2024 (Astronomy & Astrophysics)
Polarization-resolved terahertz third-harmonic generation in a superconductor NbN: dominance of Higgs mode beyond the BCS approximation
Creators: name: Matsunaga, Ryusuke
name: Tsuji, Naoto
name: Makise, Kazumasa
name: Terai, Hirotaka
name: Aoki, Hideo
name: Shimano, Ryo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Recent advances in time-domain terahertz (THz) spectroscopy have unveiled that resonantly-enhanced strong THz third-harmonic generation (THG) mediated by the collective Higgs amplitude mode occurs in s-wave superconductors, where charge-density fluctuations (CDF) have also been shown to contribute to the nonlinear third-order susceptibility. It has been theoretically proposed that the nonlinear responses of Higgs and CDF exhibit essentially different polarization dependences. Here we experimentally discriminate the two contributions by polarization-resolved intense THz transmission spectroscopy for a single-crystal NbN film. The result shows that the resonant THG in the transmitted light always appears in the polarization parallel to that of the incident light with no appreciable crystal axis dependence. When we compare this with the theoretical calculation here with the BCS approximation and the dynamical mean-field theory for a model of NbN constructed from first principles, the experimental result strongly indicates that the Higgs mode rather than the CDF dominates the THG resonance in NbN. A possible mechanism for this is discussed such as the retardation effect in the phonon-mediated pairing interaction beyond BCS.
Best-by-Simulations: A Framework for Comparing Efficiency of Reconfigurable Multicore Architectures on Workloads with Deadlines
Creators: name: Prasad, Sanjiva
Publisher: name: arXiv
Year: 2017
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences
subject: C.1.3; F.3.1; F.3.2

description: Energy consumption is a major concern in multicore systems. Perhaps the simplest strategy for reducing energy costs is to use only as many cores as necessary while still being able to deliver a desired quality of service. Motivated by earlier work on a dynamic (heterogeneous) core allocation scheme for H.264 video decoding that reduces energy costs while delivering desired frame rates, we formulate operationally the general problem of executing a sequence of actions on a reconfigurable machine while meeting a corresponding sequence of absolute deadlines, with the objective of reducing cost. Using a transition system framework that associates costs (e.g., time, energy) with executing an action on a particular resource configuration, we use the notion of amortised cost to formulate in terms of simulation relations appropriate notions for comparing deadline-conformant executions. We believe these notions can provide the basis for an operational theory of optimal cost executions and performance guarantees for approximate solutions, in particular relating the notion of simulation from transition systems to that of competitive analysis used for, e.g., online algorithms.
description: In Proceedings PLACES 2017, arXiv:1704.02418
Universal functions of the σ finger in alternative σ factors during transcription initiation by bacterial RNA polymerase
Creators: name: Oguienko, Anastasiya
name: Petushkov, Ivan
name: Pupov, Danil
name: Esyunina, Daria
name: Kulbachinskiy, Andrey
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Hematology
subject: Computational Biology

description: The bacterial σ factor plays the central role in promoter recognition by RNA polymerase (RNAP). The primary σ factor, involved in transcription of housekeeping genes, was also shown to participate in the initiation of RNA synthesis and promoter escape by RNAP. In the open promoter complex, the σ finger formed by σ region 3.2 directly interacts with the template DNA strand upstream of the transcription start site. Here, we analysed the role of the σ finger in transcription initiation by four alternative σ factors in Escherichia coli, σ38, σ32, σ28 and σ24. We found that deletions of the σ finger to various extent compromise the activity of RNAP holoenzymes containing alternative σ factors, especially at low NTP concentrations. All four σs are able to utilize NADH as a noncanonical priming substrate but it has only mild effects on the efficiency of transcription initiation. The mediators of the stringent response, transcription factor DksA and the alarmone ppGpp decrease RNAP activity and promoter complex stability for all four σ factors on tested promoters. For all σs except σ38, deletions of the σ finger conversely increase the stability of promoter complexes and decrease their sensitivity to DksA and ppGpp. The result suggests that the σ finger plays a universal role in transcription initiation by alternative σ factors and sensitizes promoter complexes to the action of global transcription regulators DksA and ppGpp by modulating promoter complex stability.
Finslerian dipolar modulation of the CMB power spectra at scales $2
Creators: name: Li, Xin
name: Lin, Hai-Nan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A common explanation for the CMB power asymmetry is to introduce a dipolar modulation at the stage of inflation, where the primordial power spectrum is spatially varying. If the universe in the stage of inflation is Finslerian, and if the Finsler spacetime is non-reversible under parity flip, $x\rightarrow-x$, then a three dimensional spectrum which is the function of wave vector and direction is valid. In this paper, a three dimensional primordial power spectrum with preferred direction is derived in the framework of Finsler spacetime. It is found that the amplitude of dipolar modulation is related to the Finslerian parameter, which in turn is a function of wave vector. The angular correlation coefficients are presented, and the numerical results for the anisotropic correlation coefficients over the multipole range $2
description: 13 pages, 1 figure, accepted by EPJC
Behavioural model derivation from swept-power load-pull data
Creators: name: Moore, Reese
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Behavioural modelling is a method of describing an electronic circuit or device, without any knowledge of the internal workings of the device. This means that when placed in simulation software, the output signal of the behavioural model should be determined from the input signal.This thesis presents a model of producing a behavioural model from load pull simulations in AWR, and verifies the correctness of the behaviooural model. This is done by applying the method to a UMS.GH25TZ1S.8S150 transistor model and comparing output measurement results of the behavioral model and transistor model. It is shown that the behavioural model has no error in AM-AM or AM-PM simulations, however there are varying degrees of accuracy in IM3 based on load impedances applied to the model. Additionally, designing an amplifier circuit from behavioural models produced by the behaviour modelling process is briefly investigated in terms of fundamental and IM3 output power levels. It si shown for a two stage amplifier design, a gain of 15.16dB is obtained and a three stage amplifier has a gain of 18.83dB. The results presented show the potential of using the designed behavioural modelling process in amplifier design, however future research into the design process is needed before full implementation.
PhasiRNAnalyzer: an integrated analyser for plant phased siRNAs
Creators: name: Fei, Yuhan
name: Feng, Jiejie
name: Wang, Rui
name: Zhang, Baoyi
name: Zhang, Hongsheng
name: Huang, Ji
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Phased siRNAs (phasiRNAs) are a class of small interfering RNAs (siRNAs) which play essential roles in plant development and defence. However, only a few phasiRNAs have been extensively studied due to the difficulties in identifying and characterizing plant phasiRNAs by plant biologists. Herein, we describe a comprehensive and multi-functional web server termed PhasiRNAnalyzer, which is able to identify all crucial components in plant phasiRNA’s regulatory pathway (phase-initiator→PHAS gene→phasiRNA cluster→target gene). Currently, PhasiRNAnalyzer exhibits the following advantages: I) It is the most comprehensive platform which hosts 170 plant species with 256 genome data, 438 cDNA data and 271 degradome data. II) It can identify all crucial components in phasiRNA’s regulatory pathway, and verify the interactions between phasiRNAs and their target genes based on degradome data. III) It can perform differential expression analysis of phasiRNAs on each PHAS gene locus between different samples conveniently. IV) It provides the user-friendly interfaces and introduces several improvements, primarily by making more accurate and efficient analysis when dealing with deep sequencing data. In summary, PhasiRNAnalyzer is a comprehensive and systemic phasiRNA analysis server with high sensitivity and efficiency. It can be freely accessed at https://cbi.njau.edu.cn/PPSA/.
Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach
Creators: name: Adji, Audrey Indrawati
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The elucidation of mechanisms whereby arterial stiffness with increasing age alters the propagation of pressure (and flow ejection) waves generated by each heart beat is still evolving and sometimes debated. The research described in this thesis aims to better characterise the age-related changes in ascending aortic blood pressure and blood flow non-invasively. This thesis investigates four key areas:- (i) measurement of aortic stiffness with pulse wave velocity; (ii) non-invasive central arterial pressure measurements; (iii) characterisation of age-related changes in central aortic pressure and flow with non-invasive methodology; (iv) relationship of cerebral arterial pressure and flow with central aortic pressure and flow. Findings of this investigation highlight the clinical importance of non-invasive measurement of central aortic pressure and aortic flow to determine ascending aortic impedance as a measure of cardiac load. The physical relationship between aortic pressure, flow and arterial impedance is quantified in terms of age-related changes. Changes in aortic flow pattern and means to derive aortic flow waveform from aortic pressure waveform non-invasively are compared with other methods. Results show that changes in the cardiac ejection pattern with age are better determined using magnetic resonance imaging compared to Doppler ultrasound techniques. Initial investigation of the effect of arterial stiffening, as occurs with age, shows that there is a relationship between the higher pressure pulsations from the heart and the damage in the brain due to the higher flow pulsations being transferred to the cerebral circulation. This investigation confirmed the changes in central aortic blood pressure and flow ejection with aging. Derivation of the aortic flow pattern from central aortic pressure is feasible, through their relationship with aortic impedance. Increased pulsatility of arterial pressure and flow may cause damage to the microvasculature in the brain and may relate to the cognitive decline with aging and disease.
Neutron star crusts from mean field models constrained by chiral effective field theory
Creators: name: Lim, Yeunhwan
name: Holt, Jeremy W.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate the structure of neutron star crusts, including the crust-core boundary, based on new Skyrme mean field models constrained by the bulk-matter equation of state from chiral effective field theory and the ground-state energies of doubly-magic nuclei. Nuclear pasta phases are studied using both the liquid drop model as well as the Thomas-Fermi approximation. We compare the energy per nucleon for each geometry (spherical nuclei, cylindrical nuclei, nuclear slabs, cylindrical holes, and spherical holes) to obtain the ground state phase as a function of density. We find that the size of the Wigner-Seitz cell depends strongly on the model parameters, especially the coefficients of the density gradient interaction terms. We employ also the thermodynamic instability method to check the validity of the numerical solutions based on energy comparisons.
description: 13 pages, 13 figures
The limitation on fair trial rights in summary criminal processes: implications for Vietnam from the experience of England and Wales
Creators: name: Bui, Dat Tien
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Minor offences account for the vast majority of criminal cases and for the most part they are subject to few of the protections of fair trial rights. The extent to which procedural rights can be limited in dealing with these offences is controversial and has not been rigorously examined. This thesis aims to investigate this issue in order to propose reforms to the Vietnamese minor offences legal framework, by offering and drawing upon a critical analysis of the experience of the United Kingdom (and in particular, the criminal jurisdiction of England and Wales). The analysis reveals a natural convergence between the cases of the England-Wales and Vietnam, concerning the expansion, fragmentation and due-process evasion of minor offence justice. Regarding a theoretical framework, this study seeks an account of crime and criminal processes that is most suitable for practice, and most compatible with the broad notion of a criminal charge under international human rights instruments. It is argued that minor offences should be considered forms of public wrong that warrant a short period of imprisonment or a non-custodial punishment. The fragmentation of minor offences into several groups calls for a suitable approach to procedural proportionality: The procedure for each type of offence should be proportionate to the severity of the punishment and should ultimately be fair as a whole. Procedural proportionality is endorsed as key for the constitutionality of summary processes. To assess the constitutionality of limitations on fair trial rights, the thesis develops two analytical tools, serving as prerequisites for the overall balancing of the proportionality test. First, it proposes a form of reasoning about three models of two-stage overall fairness and analyses their suitability for different types of offences. Second, it makes a suggestion about the inviolable core of procedural due process, the latter being comprised of several absolute elements of the right to a fair trial. As a contribution to Vietnam’s legal reform, the thesis analyses the challenges of incorporating a human-rights-limitation principle into the 2013 Constitution and argues for an extension of fair trial rights to minor offence justice. By examining the useful lessons of the English system, this study advocates the idea of treating minor offences as types of criminal offence, and embracing procedural pragmatism and procedural proportionality in Vietnam, rather than a due-process-evading form of justice.
Additional file 6: Figure S4. of Trends in cause and place of death for children in Portugal (a European country with no Paediatric palliative care) during 1987–2011: a population-based study
Creators: name: Lacerda, Ana Forjaz De
name: Gomes, Barbara
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology
subject: FOS: Biological sciences

description: Trend for home death in 0–17 year-old decedents from cancer and non-cancer CCCs in Portugal (1987–2011, N = 10,571). (DOCX 101 kb)
Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy
Creators: name: Matsukawa, Koji
name: Kukharsky, Michail S.
name: Park, Sei-Kyoung
name: Park, Sangeun
name: Watanabe, Naruaki
name: Iwatsubo, Takeshi
name: Hashimoto, Tadafumi
name: Liebman, Susan W.
name: Shelkovnikova, Tatyana A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Pathological changes involving TDP-43 protein (‘TDP-43 proteinopathy’) are typical for several neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD). FTLD-TDP cases are characterized by increased binding of TDP-43 to an abundant lncRNA, NEAT1, in the cortex. However it is unclear whether enhanced TDP-43-NEAT1 interaction represents a protective mechanism. We show that accumulation of human TDP-43 leads to upregulation of the constitutive NEAT1 isoform, NEAT1_1, in cultured cells and in the brains of transgenic mice. Further, we demonstrate that overexpression of NEAT1_1 ameliorates TDP-43 toxicity in Drosophila and yeast models of TDP-43 proteinopathy. Thus, NEAT1_1 upregulation may be protective in TDP-43 proteinopathies affecting the brain. Approaches to boost NEAT1_1 expression in the CNS may prove useful in the treatment of these conditions.
Resonant Ionization Laser Ion Source (RILIS) Development on Lu and Pr
Creators: name: Li, R.
name: Lassen, J.
name: Ames, F.
name: Kunz, P.
name: Mostamand, M.
name: Reich, B. B.
name: Teigelhöfer, A.
name: Yan, H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Resonance ionization laser ion sources are efficient and element selective ion sources, which are particularly well suited for radioactive ion beam facilities. Using TRIUMF's off-line laser ion source test stand with a system of tunable titanium sapphire (Ti:Sa) lasers, laser resonance ionization schemes for lutetium and praseodymium have been investigated with a particular interest to autoionizing states. New ionization schemes via Rydberg states and autoionizing states were found. Their investigation and comparison of ion yields at the off-line test stand will be discussed, and the data of on-line Lu delivery will be presented.
description: 17 pages, 8 figures, 4 tables
Additional file 1: of Implementation of guidelines for multidisciplinary team management of pregnancy in women with pre-existing diabetes or cardiac conditions: results from a UK national survey
Creators: name: Taylor, Cath
name: McCance, David
name: Chappell, Lucy
name: Nelson-Piercy, Catherine
name: Thorne, Sara
name: Ismail, Khaled
name: Green, James
name: Bick, Debra
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Taylor Maternal Survey. The survey used in the study (PDF 414Â kb)
Is GN-z11 powered by a super-Eddington massive black hole?
Creators: name: Bhatt, Maulik
name: Gallerani, Simona
name: Ferrara, Andrea
name: Mazzucchelli, Chiara
name: D'Odorico, Valentina
name: Valentini, Milena
name: Zana, Tommaso
name: Farina, Emanuele Paolo
name: Chakraborty, Srija
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Observations of $z \sim 6$ quasars powered by supermassive black holes (SMBHs; $M_{\rm BH} \sim 10^{8-10}\, M_\odot$) challenge our current understanding of early black hole (BH) formation and evolution. The advent of the James Webb Space Telescope (JWST) has enabled the study of massive BHs (MBHs; $M_{\rm BH}\sim 10^{6-7} \ \mathrm{M}_\odot$) up to $z\sim 11$, thus bridging the properties of $z\sim 6$ quasars to their ancestors. The JWST spectroscopic observations of GN-z11, a well-known $z=10.6$ star-forming galaxy, have been interpreted with the presence of a super-Eddington (Eddington ratio $\equiv \,λ_{\rm Edd}\sim 5.5$) accreting MBH. To test this hypothesis, we used a zoom-in cosmological simulation of galaxy formation and BH co-evolution. We first tested the simulation results against the observed probability distribution function (PDF) of $λ_{\rm Edd}$ found in $z\sim 6$ quasars. Then, in the simulation we selected the BHs that satisfy the following criteria: (a) $10 < z < 11 $, (b) $M_{\rm BH} > 10^6 \ \mathrm{M}_\odot$. Next, we apply the extreme value statistics to the PDF of $λ_{\rm Edd}$ resulting from the simulation and we find that the probability of observing a $z\sim 10-11$ MBH accreting with $λ_{\rm Edd} \sim 5.5$ in the volume surveyed by JWST is very low ($<0.2\%$). We compared our predictions with those in the literature, and discuss the main limitations of our work. Our simulation cannot explain the JWST observations of GN-z11. This might be due to (i) poor resolution and statistics in simulations, (ii) simplistic sub-grid models (e.g. BH accretion and seeding), (iii) uncertainties in the data analysis and interpretation.
description: 8 pages, 2 figures; accepted for publication in A&A
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation
Creators: name: Yue, Meng
name: Yun, Zhennan
name: Li, Shiquan
name: Yan, Guoqiang
name: Kang, Zhenhua
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: NEDD4 is an E3 ubiquitin ligase that recognizes substrates through protein–protein interactions and is involved in cancer development. This study aimed to elucidate the function of NEDD4 in colon cancer (CC) progression and its mechanism of action. NEDD4 was abundantly expressed in CC tissues and cells, and the overexpression of NEDD4 promoted the growth and metastasis of xenograft tumours as well as the tumorigenesis rate of primary CC in mouse models. In in vitro experiments, the silencing (or upregulation) of NEDD4 inhibited (or increased) the viability, invasion, and epithelial-to-mesenchymal transition of CC cells. The binding relationships between NEDD4 and FOXA1, FOXA1 and microRNA (miRNA)-340-5p, and miR-340-5p and ATF1 were validated by Co-immunoprecipitation, chromatin immunoprecipitation and luciferase assays, and NEDD4 was demonstrated to trigger FOXA1 ubiquitination and degradation. FOXA1 transcriptionally activated miR-340-5p, which subsequently bound to ATF1 mRNA. The upregulation of FOXA1 or miR-340-5p or the downregulation of ATF1 blocked certain functions of NEDD4 in CC cells. Altogether, NEDD4 was demonstrated to trigger FOXA1 ubiquitination and promote CC progression under the involvement of microRNA-340-5p suppression and ATF1 upregulation.
FAIR Implementation Workshop - Building FAIR skills at a national level
Creators: name: Dumouchel, Suzanne
name: Lazzeri, Emma
Publisher: name: Zenodo
Year: 2024

description: The "FAIR Implementation Workshop - Building FAIR skills at a National Level" took place on 27 February 2024 from 11:00 to 13:00 CET.

In this session, we explore strategies for instilling FAIR principles—making data findable, accessible, interoperable, and reusable—at both national and European Union scales. From outlining effective national-level plans to fostering collaboration through the development of FAIR Competence Center Networks, this workshop aims to equip participants with actionable insights to navigate the FAIR data landscape. This event is organized in conjunction with the Skills4EOSC project.
Predicting The One-Particle Density Matrix With Machine Learning
Creators: name: Hazra, S.
name: Patil, U.
name: Sanvito, S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Two of the most widely used electronic structure theory methods, namely Hartree-Fock and Kohn-Sham density functional theory, both requires the iterative solution of a set of Schrödinger-like equations. The speed of convergence of such self-consistent field process depends on the complexity of the system under investigation and on the initial guess for the density matrix. An initial density matrix close to the ground-state one will effectively allow one to cut out many of the self-consistent steps necessary to achieve convergence. Here, we predict the density matrix of Kohn-Sham density functional theory by constructing a neural network, which uses the atomic positions as only information. Such neural network provides an initial guess for the density matrix far superior to any other recipes available, in particular for molecules with metallic bonds. Furthermore, the quality of such neural-network density matrix is good enough for the evaluation of interatomic forces. This allows us to run accelerated {\it ab-initio} molecular dynamics with little to no self-consistent steps.
A Model to Study Finite-Size and Magnetic Effects on the Phase Transition of a Fermion Interacting System
Creators: name: Corrêa, Emerson B. S.
name: Linhares, César A.
name: Malbouisson, Adolfo P. C.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We present a model to study effects from an external magnetic field, chemical potential, and finite size, on the phase structure of a massive four- and six-fermion interacting system. These effects are introduced by a method of compactification of coordinates, a generalization of the standard Matsubara prescription. Through the compactification of the $z$ coordinate and of imaginary time, we describe a heated system with the shape of a film of thickness $L$, at temperature $β^{-1}$ undergoing first- or second-order phase transition. We have found a strong dependence of the temperature transition on the constants couplings $λ$ and $η$. Besides magnetic catalysis and symmetry breaking for both kinds of transition, we have found an inverse symmetry breaking phenomenon with respect to first-order phase transition.
Re-membering Michael Field: scenes from a biographical praxis
Creators: name: Morley, Rachel Natalie
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: THIS thesis comprises a collection of published and submitted essays presented in the form of the thesis by publication model. The essays explore the experience of researching and writing biography in order to develop an understanding of the effects of that experience on both the subject who is written, and on the subject who writes. The project takes as its starting point the idea that 'doing biography' is not purely an intellectual endeavour, as some critics would have it, but that it is also a deeply personal and affective one too. To this effect the project deploys theories of affect and cognition, combined with a literary/ethnographic approach, in order to document and analyse some of the ways in which the researching/writing experience influences how and what biographers learn, and how such experiences might be productively harnessed for conscious inclusion within the final work. Where biographical theorists have tended to focus on interpretive studies of the already produced biographical text, this project sees the processes leading to that production as both an important and generative subject for study itself. -- Here, critical theory is enhanced through creative discourse, much of which is drawn from a series of biographical explorations based on my own research into the English-born couple Katharine Bradley (1846-1914) and her niece Edith Cooper (1862-1913), two Victorian poet/dramatists better known by their joint pen-name 'Michael Field'. The critical/creative framework provides the opportunity to discuss (and reveal) through praxis, some of the mechanical and philosophical questions pertinent to the study. Matters of praxis include the choice of subject, the identity of the biographer, the use of certain biographical materials and sources, the biographical pilgrimage as journey/quest, the act of writing/rewriting, and the final production itself. These issues inevitably lead to an exploration of more complex matters such as the cultural/social/historical impulse/s that connect biographers to particular subjects, and the impact of that relationship (whether 'positive' or not) on writing; the relationship between the researcher and the archive; the function of life-writing; and questions and issues pertaining to postmodern writing techniques. The challenge is to develop a writing technique that engages with the Experience o f doing and making biography in such a way as not to diminish or detract from the primary task - to tell the story of the other.