cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Propagation of Ultra High Energy Protons over Cosmological Distances and Implications for Topological Defect Models
Creators: name: Protheroe, R. J.
name: Johnson, P. A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We describe the results of a hybrid matrix--Monte Carlo calculation of cascading of UHE cosmic rays and $γ$-rays through the cosmic background radiation fields over cosmological distances. We calculate the $γ$-ray and neutrino emission that results from the cascade, as well as the effect of cascading on the primary spectrum. We discuss the results for various cosmic ray injection spectra and primary species. Certain models for the production of the highest energy cosmic rays are ruled out.
description: 32 pages, uuencoded postscript, also available from http://www.physics.adelaide.edu.au/astrophysics/
Simia silenus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Atelidae
Simia
Simia silenus

description: Simia silenus [spec. nov.]
S. caudata barbata, corpore nigro, barba nivea prolixa.
Simia Callitriches magnitudine cynocephalorum. Alp. aegypt. 242?
Habitat in Asia: Zeylona, Java &c.
Species obscurior, ignotis Pedum unguibus aliisque plurimis attribucis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 26, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
MOESM1 of Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3
Creators: name: P. Bojarová
name: M. Tavares
name: D. Laaf
name: L. Bumba
name: L. Petrásková
name: R. Konefał
name: M. Bláhová
name: H. Pelantová
name: L. Elling
name: T. Etrych
name: P. Chytil
name: V. Křen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1. Structural characterization of disaccharides 5–7 (NMR data and spectra, MS spectra, HPLC chromatograms of preparations), procedures of the synthesis of polymer precursors and glyconanomaterials, structural characterization of selected compounds (NMR spectra), hydrodynamic radii of selected compounds.
Utricular and visual aspects of inner ear disorders
Creators: name: Agarwal, Kiran
Publisher: name: Imperial College London
Year: 2015

description: The research described in this thesis is about investigation of the two less well understood mechanisms of balance system, namely utricular function and interactions of visual and vestibular system. Utricules are part of otolith apparatus and sense linear acceleration including gravity and lateral head tilts. Recent advances in rotational technology allow robust methods of assessment of unilateral utricular function using centrifugation techniques. Unilateral centrifugation generates substantial linear acceleration and the utricular response can be measured via tilt perception using subjective visual vertical (chapter 2). Utricular function was studied in common vestibular disorders seen in clinics, like chronic vestibular neuritis, benign positional paroxysmal vertigo, unilateral Ménière’s disease, migraine and bilateral vestibular hypofunction. Bilateral vestibular hypofunction produced significantly low utricular gain (chapter 3). A detailed study of the utricular function of larger group of unilateral Ménière’s disease showed significantly greater utricular asymmetry and lower utricular gain than normal controls. Interestingly, hearing loss was a predictor of utricular asymmetry (chapter 4). There was poor correlation between subjective measures and audiovestibular function. The chronic course of Ménière’s disease is well known with slow decline over years and absence of correlation between symptoms and function may point to ‘burn out’ as long term phenomenon (chapter 5). An investigation into visual dependence and vertigo was performed to understand the effect of visual dependence on tilt perception in chronic vertigo. Individuals with vestibular symptoms can have increased visual dependency and migraineurs can have a non-adaptable increase in visual dependency (chapter 6). In summary, we found that the unilateral centrifugation is a safe and well tolerated technique and provides additional, potentially useful information about utricular function. In future, the study of utricular function during acute phases of vertigo will further help overall understanding of otolith pathophysiology and mechanisms used for compensation.
Measuring Hubble's Constant in our Inhomogeneous Universe
Creators: name: Shi, Xiangdong
name: Widrow, Lawrence M.
name: Dursi, L. Jonathan
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent observations of Cepheids in the Virgo cluster have bolstered the evidence that supports a Hubble constant in 70-90 km/s/Mpc range. This evidence, by and large, probes the expansion of the Universe within 100 Mpc. We investigate the possibility that the expansion rate within this region is systematically higher than the true expansion rate due to the presence of a local, large underdense region or void. We begin by calculating the expected deviations between the locally measured Hubble constant and the true Hubble constant for a variety of models. We also discuss the expected correlations between these deviations and mass fluctuation for the sample volume. We find that the fluctuations are small for the standard cold dark matter as well as mixed dark matter models but can be substantial in a number of interesting and viable nonstandard scenarios. However, deviations in the Hubble flow for a region of radius 200 Mpc are small for virtually all reasonable models. Therefore, methods based on supernovae or the Sunyaev-Zel'dovich effect, which can probe 200 Mpc scales, will be essential in determining the true Hubble constant. We discuss, in detail, the fluctuations induced in the cosmic background radiation by voids at the last scattering surface. In addition, we discuss the dipole and quadrupole fluctuations one would expect if the void enclosing us is aspherical or if we lie off-center.
description: 20 pages (58K), 8 Postscript figures (111K compressed); Submitted to MNRAS. Postscript source available at http://astro.queensu.ca/~dursi/preprints/
Entanglement evolution and generalised hydrodynamics: noninteracting systems
Creators: name: Bertini, Bruno
name: Fagotti, Maurizio
name: Piroli, Lorenzo
name: Calabrese, Pasquale
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The large-scale properties of homogeneous states after quantum quenches in integrable systems have been successfully described by a semiclassical picture of moving quasiparticles. Here we consider the generalisation for the entanglement evolution after an inhomogeneous quench in noninteracting systems in the framework of generalised hydrodynamics. We focus on the protocol where two semi-infinite halves are initially prepared in different states and then joined together, showing that a proper generalisation of the quasiparticle picture leads to exact quantitative predictions. If the system is initially prepared in a quasistationary state, we find that the entanglement entropy is additive and it can be computed by means of generalised hydrodynamics. Conversely, additivity is lost when the initial state is not quasistationary; yet the entanglement entropy in the large-scale limit can be exactly predicted in the quasiparticle picture, provided that the initial state is low entangled.
description: 13 pages, 4 figures
Additional file 4 of sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression
Creators: name: He, Yuan
name: Chhetri, Surya B.
name: Arvanitis, Marios
name: Srinivasan, Kaushik
name: Aguet, François
name: Ardlie, Kristin G.
name: Barbeira, Alvaro N.
name: Bonazzola, Rodrigo
name: Im, Hae Kyung
name: Brown, Christopher D.
name: Battle, Alexis
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4 Review history.
On Quasar Masses and Quasar Host Galaxies
Creators: name: Laor, Ari
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The mass of massive black holes in quasar cores can be deduced using the typical velocities of Hb-emitting clouds in the Broad Line Region (BLR) and the size of this region. However, this estimate depends on various assumptions and is susceptible to large systematic errors. The Hb-deduced black hole mass in a sample of 14 bright quasars is found here to correlate with the quasar host galaxy luminosity, as determined with the Hubble Space Telescope (HST). This correlation is similar to the black hole mass vs. bulge luminosity correlation found by Magorrian et al. in a sample of 32 nearby normal galaxies. The similarity of the two correlations is remarkable since the two samples involve apparently different types of objects and since the black hole mass estimates in quasars and in nearby galaxies are based on very different methods. This similarity provides a ``calibration'' of the Hb-deduced black hole mass estimate, suggesting it is accurate to +-0.5 on log scale. The similarity of the two correlations also suggests that quasars reside in otherwise normal galaxies, and that the luminosity of quasar hosts can be estimated to +-0.5 mag based on the quasar continuum luminosity and the Hb line width. Future imaging observations of additional broad-line active galaxies with the HST are required in order to explore the extent, slope, and scatter of the black hole mass vs. host bulge luminosity correlation in active galaxies.
description: Accepted for publication in ApJ Letters, 7 pages, aas2pp4.sty
Simia faunus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Atelidae
Simia
Simia faunus

description: Simia faunus [spec. nov.]
S. caudata barbata, cauda apice floccosa. Syst. nat. 3.
Cercopithecus barbatus 1. Clus. exot. 371. t. 371. Nic{?X}- remb. nat. 179. Raj. quadr. 153.
Habitat
Corpus nigricans; Barba, Pectus, anteriora abdominis alba.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 26, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Nostalgia and ethnocentric product preferences
Creators: name: Dimitriadou, Marika
Publisher: name: Imperial College London
Year: 2015

description: Understanding consumers’ preferences is central in marketing. Their tendency to prefer products of domestic rather than foreign origin, and the impact their emotional and affective state has on their purchasing decisions are well-documented in the literature. This thesis connects these two research themes by examining the impact feelings of nostalgia have on ethnocentric product preferences. The focus on nostalgia is not accidental. Advertising and marketing campaigns of several multinational companies have recently attempted to trigger such feelings amongst consumers in order to promote their products. The thesis begins by offering a more robust investigation for the presence of country of origin effects and the impact of consumer ethnocentrism on it, using a multi- cultural sample and measuring individuals’ actual preferences. Using separate inducements for nostalgia — at the ‘personal’ level, referring to past events the consumers experienced alone, and at the ‘collective’ level, referring to past events the consumers experienced in the company of others — it proceeds by providing evidence suggesting that feelings of nostalgia significantly increase preferences for domestic products, as well as ratings of their perceived quality. Both inducements have similar effects on preferences and ratings. Subsequently investigating the underlying psychological mechanism responsible for the effect of nostalgia on ethnocentric product preferences, the thesis provides evidence that self-reported ‘meaning of life’ — a composite measure previously linked to nostalgia — is a significant mediator of this effect; having a significantly positive indirect effect on both preferences for and ratings of domestic products. The thesis concludes by discussing the implications these findings have for man- agerial practice and outlining future directions for marketing research in this field.
The molecular basis of persistent staphylococcal bacteraemia
Creators: name: Painter, Kimberley Louise
Publisher: name: Imperial College London
Year: 2016

description: In Staphylococcus aureus, the accessory gene regulator (Agr) system controls the expression of toxins that damage the host. Agr is required for bacterial survival in a range of animal infection models, although its role during bacteraemia is poorly understood. Agr is also important for survival of S. aureus in the presence of neutrophils in vitro, but there is paradoxical clinical evidence that loss of Agr (either via agr mutations or mutations that result in the small colony variant [SCV] phenotype) promotes bacterial survival during bacteraemia. Therefore, the aim of this thesis was to decipher the role of Agr in the survival of S. aureus in blood. Mutants with deletions in the agr operon or in genes that confer the SCV phenotype were tested alongside their isogenic wildtype strain in an ex vivo whole human blood model. Functional Agr was shown to be important for maximal survival of wildtype S. aureus in blood. However, S. aureus could survive in an Agr-independent manner as an SCV, the survival of which was much higher in blood than wildtype bacteria. This elevated SCV survival in blood was due to increased resistance to the neutrophil oxidative burst. For one SCV type, this was partly due to increased catalase activity, although this was not the case for the other type of SCV examined, suggesting additional mechanisms of oxidative stress resistance. Inductively coupled plasma mass-spectrometry revealed that SCVs had reduced levels of iron and increased levels of manganese relative to the wildtype, which could protect against exposure to reactive oxygen species. In conclusion, the data within this thesis support the importance of Agr for S. aureus survival in the blood, as well as revealing a novel Agr-independent mechanism by which S. aureus can persist in the host.
Development of a clinical decision support system to assess the risk of lung cancer for prevention and earlier diagnosis in people with HIV
Creators: name: Amoruccio, Vincent
Publisher: name: No Publisher Supplied
Year: 2021

description: The advent of antiretroviral therapy (ART) changed the prognosis of HIV. People with HIV (PWH) live longer lives but are susceptible to the same age-related disease as people without HIV. Cancer is a leading cause of death for PWH, and lung cancer is the leading cause of cancer-related death. Smoking and increased age are the primary causes of lung cancer in the general population. Still, they do not explain the significant increase in lung cancer incidence in PWH. Risk factors specific to HIV, such as immunocompetence and respiratory disease, present more lung cancer risk in PWH. Existing guidance for lung cancer prevention exclude PWH and do not consider HIV specific risk factors. This deficiency has led to increased incidence and mortality from lung cancer and at younger ages and more advanced stages.This study addresses the urgent and unmet need to develop a lung cancer risk assessment tool for prevention and earlier diagnosis in PWH. Using an integrated set of public-use data of 7,607 HIV-positive men and women from Johns Hopkins University, knowledge-based risk factors specific to PWH were formed using logistic regression models predicting lung cancer. Twenty-one HIV-specific risk factors were identified from 51 candidates using bivariable logistic regression models conditioned on gender, race, and smoking status. Similarly, stratified multivariable logistic regression models determined 14 lung cancer predictors for PWH. A multiplicate risk score was created for each risk factor and then summed to create a single risk score. Risk stratifications for low, medium and high risk were identified using the quartiles of risk.The risk score in the knowledge-base had a sensitivity of 77%. It led to the developing of the inference engine and a web-based Clinical Decision Support System (CDSS) for PWH and their clinicians. A random sample of 20 patients reserved for validating the CDSS had a sensitivity of 80%, while criteria from existing guidelines for the general population missed between 97 and 100% of lung cancer cases. These results demonstrate that a risk assessment tool, such as this CDSS, predicts lung cancer in PWH better than existing guidance and can prevent or diagnose it earlier.
Software for producing trichromatic images in astronomy
Creators: name: Morel, Sebastien
name: Davoust, Emmanuel
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a software package for combining three monochromatic images of an astronomical object into a trichromatic color image. We first discuss the meaning of "true" colors in astronomical images. We then describe the different steps of our method, choosing the relevant dynamic intensity range in each filter, inventorying the different colors, optimizing the color map, modifying the balance of colors, and enhancing contrasts at low intensity levels. While the first steps are automatic, the last two are interactive.
description: 12 pages (including 2 figures) uuencoded compressed Postscript file. To appear in Experimental Astronomy
Additional file 3: of Occurrence, Risk Factors, Prognosis and Prevention of Swimming-Induced Pulmonary Oedema: a Systematic Review
Creators: name: Spencer, Sarah
name: Dickinson, John
name: Forbes, Lindsay
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Data extraction forms. (DOCX 17 kb)
A scientific approach to improvement: the use of Plan-Do-Study-Act cycles in healthcare
Creators: name: McNicholas, Chris
Publisher: name: Imperial College London
Year: 2016

description: This thesis contributes further understanding on how to pursue improvements in healthcare and informs the academic growth of improvement science. Derived from manufacturing industries, QI methods are common approaches to structure the process of making improvements in healthcare, however, questions over their scientific legitimacy and application have arisen due to their varied effectiveness. A review of how QI methods are associated with science identifies the prominent theoretical role of QI methods in facilitating change and improvement by supporting the local application of the scientific method. The Plan-Do-Study-Act (PDSA) cycle method is identified as playing a central role in this and a theoretical framework is developed to assess the use of the method in published and local team’s accounts. This demonstrates that the method is commonly not used with high fidelity; a key novel addition to the research literature. Studies are presented to further understand the reality of PDSA cycle use. These provide a novel identification and empirically grounded description of the social dimensions of applying the PDSA cycle method including negotiating through a single PDSA cycle and navigating the iteration and scale up of change and complexity of learning. A novel association between understanding, intentions and process of applying the PDSA cycle method and the fidelity of the methods use is also presented as well as the views of teams using the method which demonstrate different conceptual views of the PDSA cycle method and the wider social benefits of using the method. Overall, this thesis provides clarity in regards to the technical and social elements of PDSA cycle use. It demonstrates research approaches to open the “black box” of PDSA cycle use and investigate the use of QI methods more widely. It calls for continued exploration of applying science to improve the quality of healthcare for patients.
Model averaging for robust extrapolation in evidence synthesis
Creators: name: Röver, Christian
name: Wandel, Simon
name: Friede, Tim
Publisher: name: arXiv
Year: 2018
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Extrapolation from a source to a target, e.g., from adults to children, is a promising approach to utilizing external information when data are sparse. In the context of meta-analysis, one is commonly faced with a small number of studies, while potentially relevant additional information may also be available. Here we describe a simple extrapolation strategy using heavy-tailed mixture priors for effect estimation in meta-analysis, which effectively results in a model-averaging technique. The described method is robust in the sense that a potential prior-data conflict, i.e., a discrepancy between source and target data, is explicitly anticipated. The aim of this paper to develop a solution for this particular application, to showcase the ease of implementation by providing R code, and to demonstrate the robustness of the general approach in simulations.
description: 18 pages, 7 figures, 5 tables
Phase stability in steels under electropulsing
Creators: name: Lu, Wenjun
Publisher: name: Imperial College London
Year: 2015

description: There are increasing interests to alternate the microstructure and hence the properties of steels that are applied in various environment conditions using a work-efficient and energy-saving manner. The desirable microstructure evolution is often not achievable by means of conventional thermo-mechanical processing and solid-state phase transition. This thesis has considered four fundamental engineering problems, namely (i) the possibility of anti-aging processing for the aged steels in service at high temperature, (ii) the recovery of the lost strength for the steels at high temperature, (iii) the suspension of crack initiation and propagation during cold-working of steels with eutectoid microstructures and (iv) the regaining of strength during tempering of a steel containing martensite. Phase stability in the processing environment is the primary concern in each of the list problems because it presents, in thermodynamically, the possibility to achieve the goals using the designed processing. Electropulsing processing has been considered and integrated with the conventional thermomechanical processing in the development of this PhD thesis. The so-called electropulsing treatment utilises electric current pulses with high peak current density and short pulse duration. Due to the nature of the short duration pulse, the energy consumption is very low. The high current density enables a very strong impact of electropulsing on the microstructure evolution and hence is work efficient. Following results have been obtained through the study： • Using the appropriate electropulsing parameters, the formed secondary phase (e.g. χ-phase) by precipitation in 316L stainless steels at elevated temperature can be dissolved. Electropulsing processing can supress the precipitation and homogenize the alloying elements in the stainless steel. The stability of the secondary phases in the stainless steel has been changed by the imposed electropulse. • Electropulsing treatment is able to alternate the delta-ferrite phase transition. This has been proved in the treatment of 2205 duplex stainless steel. The new format of phase transition causes strengthening of the steel at high temperature. The stability of phases in the steel has been affected by the applied electropulsing treatment. • For the light steels containing high aluminium composition, electropulsing is able to affect the thermodynamic stability and grain morphology of κ-carbide. This leads to significant improvement of steel formability. • Application of electropulsing processing to dual-phase automotive steel changes the stability of martensite phase. The processing improve the mechanical properties and refined the microstructure of this steel. The fundamental understanding of the experimental observations has been developed based on the thermodynamic and kinetic analysis.
The purpose of astronomy
Creators: name: Davoust, Emmanuel
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: This is a presentation of the purpose of astronomy in the context of modern society. After exposing two misconceptions about astronomy, I detail its role in five domains, certified knowledge, incorporated abilities, innovations, collective goods, and popular science; with each domain is associated an institution, an incentive, and a method of evaluation. Finally, I point out the role of astronomy as a source of inspiration in other fields than science.
description: 9 pages (including 1 figure) uuencoded compressed Postscript file. To appear in Vistas in Astronomy
Additional file 3 of Morphological characteristics and transcriptome analysis at different anther development stages of the male sterile mutant MS7–2 in Wucai (Brassica campestris L.)
Creators: name: Wang, Jian
name: Yang, Yitao
name: Zhang, Lei
name: Wang, Shaoxing
name: Yuan, Lingyun
name: Chen, Guohu
name: Tang, Xiaoyan
name: Hou, Jinfeng
name: Zhu, Shidong
name: Wang, Chenggang
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Fig. S3. Heatmap analysis of phenylpropanoid biosynthesis-related genes.
Simia paniscus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Atelidae
Simia
Simia paniscus

description: Simia paniscus [spec. nov.]
S. caudata barbata, cauda prehensili, palmis subtetradactylis. Syst. nat. 3.
Simia fusca major, palmis tetradactylis, cauda prehensili ad apicem subtus nuda. Brown. jam. 489.
Guariba. Marcgr. bras. 229. t. 226. Raj. quadr. 153.
Habitat in America meridionali: Brasilia.
Corpus nigrum. Pedes & Cauda dimidia exterior brunnea; Caudae extremitas hinc nuda, qua, quidquid e terra elevet, prehendit. Digiti Pedum 4-5. Z. Hallman; est vero Pollex reliquis minor, introrsum a caeteris remotus, Unguesque manuum rotundati, pedum subulati. D. Aymen. Pullos in dorso gerit, qui ambiunt matris corpus posterius angustius: Oriente & Occiaente sole congregantur concionem celebrantes. Marcgr.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 26, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Investigation of phenotypic rescue of Mybpc3 deficient mouse
Creators: name: Abou Al Saud, Sara
Publisher: name: Imperial College London
Year: 2015

description: Mutations in the myosin binding protein C gene (MYBPC3) are a frequent cause of hypertrophic cardiomyopathy (HCM) and calcineurin plays a major role in hypertrophic remodelling. However, a functional link between MYBPC3 mutations and calcineurin has not been investigated. Mybpc3 knock out (KO) mice were generated and an increase in the regulator of calcineurin 1 (Rcan1) mRNA expression was detected, indicating an increase in calcineurin activity (Knöll et al. unpublished data). Accordingly, it was hypothesised that calcineurin, particularly its major β-isoform (CnAβ), plays a role in the pathogenesis of these mice. Therefore we investigated Mybpc3/CnAβ double KO (dKO) mice. Our results confirmed that the severe heart failure (HF) phenotype observed in Mybpc3 KO mice is completely rescued by additional ablation of CnAβ as judged by echocardiography, gravimetric analysis, histology and electron microscopy studies. We also have measured muscle contractility in skinned cardiac trabeculae from dKO mice and demonstrated that the rescue was present at the level of the contractile apparatus. Moreover, this rescue was specific to Mybpc3 KO mice as the phenotype of a mouse model expressing the apical hypertrophic cardiomyopathy-causing mutation ACTC E99K actin was more severe in ACTC E99K/ CnAβ double transgenic (dTG) mice. Crucially, it was found that ventricular myosin light chain (MLC2v) was hyperphosphorylated in the Mybpc3/CnAβ dKO mice. Furthermore, calcineurin was shown to dephosphorylate MLC2v in vitro. We therefore investigated whether MLC2v hyperphosphorylation per se could rescue the Mybpc3 KO phenotype. Mybpc3 KO mice were injected with AAV9 overexpressing pseudophosphorylated MLC2v (S14/15D; AAV9-pMLC2v), cardiomyocytes were transfected with adv-pMLC2v, and a construct to create a TG mice overexpressing pMLC2v was made. 3 | P a g e The AAV9-pMLC2v injected mice were studied in detail. A maximal improvement in cardiac function was observed 6 weeks after injection. Echocardiography demonstrated ~20%EF and ~25%FS increase in the Mybpc3 KO hearts whilst there was a trend to diminished performance in WT. However, two different concentrations of AAV9-pMLC2v resulted in gravimetric parameters, left ventricle (LV) dimensions, and typical HCM abnormalities indistinguishable from untreated Mybpc3 KO mice. The beneficial effects of MLC2v hyperphosphorylation on the regulation and enhancement of myocardial contractile function point to a possible molecular mechanism in attenuating the hypertrophy and enhancing myocardial function in the dKO mice. Genetic testing combined with inhibition of calcineurin and/or modification of MLC2v phosphorylation in individuals affected by MYBPC3 mutations, might provide a novel strategy to prevent and/or treat specifically this otherwise serious condition.
Piecewise Adiabatic Following: General Analysis and Exactly Solvable Models
Creators: name: Gong, Jiangbin
name: Wang, Qing-hai
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The dynamics of a periodically driven system whose time evolution is governed by the Schrödinger equation with non-Hermitian Hamiltonians can be perfectly stable. This finding was only obtained very recently and will be enhanced by many exact solutions discovered in this work. The main concern of this study is to investigate the adiabatic following dynamics in such non-Hermitian systems stabilized by periodic driving. We focus on the peculiar behaviour of stable cyclic (Floquet) states in the slow-driving limit. It is found that the stable cyclic states can either behave as intuitively expected by following instantaneous eigenstates, or exhibit piecewise adiabatic following by sudden-switching between instantaneous eigenstates. We aim to cover broad categories of non-Hermitian systems under a variety of different driving scenarios. We systematically analyse the sudden-switch behaviour by a universal route. That is, the sign change of the critical exponent in our asymptotic analysis of the solutions is always found to be the underlying mechanism to determine if the adiabatic following dynamics is trivial or piecewise. This work thus considerably extends our early study on the same topic [Gong and Wang, Phys. Rev. A 97, 052126 (2018)] and shall motivate more interests in non-Hermitian systems.
description: 16 pages, 7 figures, to be published on Phys. Rev. A
MOESM8 of Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas
Creators: name: Jonckheere, Nicolas
name: Seuningen, Isabelle Van
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 8: Figure S5. Overall survival of MUC4/MUC16/MUC20 high and low risk groups in cancer datasets available in TCGA. (A) Overall survival of MUC4/MUC16/MUC20 high and low risk groups in bladder cancer, colon cancer, lung adenocarcinoma, lung squamous adenocarcinoma, skin cancer and stomach cancer. High risk and low risk cohorts were determined by SurvExpress optimized algorithm. Log rang test and Hazard ratio were calculated to compare both cohorts. The numbers below horizontal axis represent the number of individuals not presenting the event of MUC4 high and low risk group along time. (B) Overall survival of MUC4/MUC16/MUC20 high and low risk group in liver and acute myeloid leukemia (AML).
Visual Search for Galaxies near the Northern Crossing of the Supergalactic plane by the Milky Way
Creators: name: Hau, G. K. T.
name: Ferguson, H. C.
name: Lahav, O.
name: Lynden-Bell, D.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have visually examined twelve Palomar red Plates for galaxies at low Galactic latitude b, where the Supergalactic Plane (SGP) is crossed by the Galactic Plane (GP), at Galactic longitude l ~135 degrees. The catalogue consists of 2575 galaxy candidates, of which 462 have major axis diameters d >= 0.8 arc min (uncorrected for extinction). Galaxy candidates can be identified down to |b| ~ 0 degrees. One of our galaxy candidates (J24 = Dwingeloo 1) has recently been discovered independently in 21cm by Kraan-Korteweg et al. (1994) as a nearby galaxy. Comparisons with the structures seen in the IRAS and UGC catalogues are made. We compare the success rate of identifying galaxies using the IRAS Point Source Catalogue under different colour selection criteria. The criteria that require both the 60 micron and 100 micron fluxes to be of high quality, have the highest probability of selecting a galaxy (with d >= 0.6 arc min), but at the expense of selecting a smaller number of galaxies in total.
description: uuencoded compressed postscript, without figures. The figures are available at http://www.ast.cam.ac.uk/preprint/PrePrint.html
Survey of Correction Techniques for Remote Sensing Devices in Complex Flow
Creators: name: Black, Andrew
name: Mazoyer, Paul
name: Wylie, Scott
name: Debnath, Mishu
name: Lammers, Andrew
name: Spalding, Taurin
name: Schultz, Robert
Publisher: name: Zenodo
Year: 2020
Subjects: wind energy
wind lidar
complex terrain
complex flow
resource assessment

description: As part of its mission to reduce the uncertainty of preconstruction wind resource estimates, the Consortium for the Advancement for Remote Sensing (CFARS) is engaged in a survey of correction techniques for remote wind sensing devices in complex terrain. This webinar presented and compared correction techniques from several suppliers (Leosphere, WindSim, Meteodyn) when applied to data collected by the most prominent sensing devices (Triton, WindCube, ZX). All techniques show similar results: uncorrected RSD wind speeds differ from cup measurement by 2%-5% and corrected data are all within ±1%. This study also examines anemometer biases due to flow inclination. The webinar goes beyond the CFARS presentation to AWEA 2020, providing further detail on the datasets, terrain classification and methods used to compare mast and lidars. Andrew Hastings Black, Scott Wylie, and Paul Mazoyer presented the survey results. The discussion was moderated by Andy Clifton from IEA Wind Task 32. This repository includes the following files: An introduction by Task 32 ("2020 12 08...") The main presentation ("CFARS_...").
description: This material was presented in an IEA Wind Task 32 webinar on 8 December 2020. For more information about IEA Wind Task 32 see https://community.ieawind.org/task32/home. For more information about CFARS see http://www.cfars.org/.
Search for an exotic decay of the Higgs boson to a pair of light pseudoscalars in the final state with two b quarks and two $τ$ leptons in proton-proton collisions at $\sqrt{s}=$ 13 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for an exotic decay of the Higgs boson to a pair of light pseudoscalar bosons is performed for the first time in the final state with two b quarks and two $τ$ leptons. The search is motivated in the context of models of physics beyond the standard model (SM), such as two Higgs doublet models extended with a complex scalar singlet (2HDM+S), which include the next-to-minimal supersymmetric SM (NMSSM). The results are based on a data set of proton-proton collisions corresponding to an integrated luminosity of 35.9 fb$^{-1}$, accumulated by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV. Masses of the pseudoscalar boson between 15 and 60 GeV are probed, and no excess of events above the SM expectation is observed. Upper limits between 3 and 12% are set on the branching fraction $\mathcal{B}$(h $\to$ aa $\to$ 2$τ$2b) assuming the SM production of the Higgs boson. Upper limits are also set on the branching fraction of the Higgs boson to two light pseudoscalar bosons in different 2HDM+S scenarios. Assuming the SM production cross section for the Higgs boson, the upper limit on this quantity is as low as 20% for a mass of the pseudoscalar of 40 GeV in the NMSSM.
description: Replaced with the published version. Added the journal reference. All the figures and tables, including additional supplementary figures, can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-17-024 (CMS Public Pages)
Simia diana Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Atelidae
Simia
Simia diana

description: Simia diana [spec. nov.]
S. caudata barbata, fronte barbaque fastigiata. Linn. act. Stockh. 1754. p. 210. t. 6.
Cercopithecus barbatus guineensis. Marcgr. bras. 227. t. 228. Raj. quadr. 159.
Cercopithecus barbatus 2. Clus. exot. 311.
Habitat in Guinea.
Magnitudo Felis majoris, nigra punctis albidis. Dorsum postice ferrugineum. Femora subtus helvola. Gula pectusque alba. Frons pilis erectis, albis, fastigiatis linea transversa in formam lunae crescentis. Barba fastigiata, nigra, subtus alba, insidens tuberi adiposo. Linea alba ab ano ad genua ab exteriori latere femorum ducta. Ludibunda omnia dejicit, peregrinos nutitando salutat; irata ore hiat maxillasque exagitat; vocata respondet greck
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on pages 26-27, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Towards 4U 1630-47: a black-hole soft X-ray transient odyssey
Creators: name: Kuulkers, Erik
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: 4U 1630-47 is a black-hole X-ray transient with one of the shortest recurrence times. Despite its regular outburst behaviour little is known about this source. Only recently has attention to this system increased. I discuss there the basic known (X-ray) properties of 4U 1630-47 and report on X-ray and radio observations obtained during its recent outburst, starting in 1998 February. These observations strengthen some of the similarities seen between 4U 1630-47 and the Galactic superluminal sources GRO J1655-40 and GRS 1915+105, and provide the first detection of 4U 1630-47 in the radio. Using an updated outburst ephemeris I predict the next outburst to occur about a week before Christmas 1999.
description: 4 pages, 2 figures, updated how to refer to this paper: to appear in: R.N.Ogley, J. Bell Burnell (eds.), 2nd Workshop on Galactic Sources with Relativistic Jets, NewAR, 42, in press
Organic mixed ionic/electronic conductors for bioelectronics applications
Creators: name: Pacheco Moreno, Celia Maria
Publisher: name: Imperial College London
Year: 2016

description: The bioelectronics field has incorporated an increasing variety of conducting polymers in applications that involve mixed ionic/electronic transport, yet there is still a lack of design rules to purposefully tune the electronic and ionic contributions to a material's conductivity, as well as processing methods to further control and understand their interplay. New undoped co-polymers were explored as electroactive materials in aqueous media. The range of materials allowed establishing a simple design rule with potential to be explored in other model semiconductors. The most hydrophilic system showed promising response when benchmarked with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) in order to be employed in new operation modes of devices which rely on the electrochemical doping of the active layer, such as organic electrochemical transistors (OECTs). The capabilities of the most promising system were further exploited as an ion-to-electron converter by creating multicomponent systems that included a polar insulator to tune their ionic transport. The straight-forward and chemically inert blending approach showed enhanced transport of ionic species while maintaining their electronic transport as well as displaying characteristic response times linked to the presence of the polar phase. By using the semiconductor as a model system and controlling the volume of aggregates present in the solid-state by means of processing, a phenomenological description was given of ionic transport in different regions of semicrystalline polymers along with their associated decay rates. Finally, the effect of humidity in the charge transport of the undoped co-polymers was explored, with a focus on elucidating ionic contributions from electronic ones. The incorporation of a ionic conductor, Nafion, in a bilayer structure was explored and showed an intimate interaction between the proton conductor and the electronic conductor. The potential of the multilayer structures as humidity sensors and other remarkable features found in their charge transport make these promising systems for further applications in bioelectronics.
Resilient entanglement gates for trapped ions
Creators: name: Webb, A. E.
name: Webster, S. C.
name: Collingbourne, S.
name: Bretaud, D.
name: Lawrence, A. M.
name: Weidt, S.
name: Mintert, F.
name: Hensinger, W. K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Constructing a large scale ion trap quantum processor will require entangling gate operations that are robust in the presence of noise and experimental imperfection. We experimentally demonstrate how a new type of Mølmer-Sørensen gate protects against infidelity caused by heating of the motional mode used during the gate. Furthermore, we show how the same technique simultaneously provides significant protection against slow fluctuations and mis-sets in the secular frequency. Since this parameter sensitivity is worsened in cases where the ions are not ground state cooled, our method provides a path towards relaxing ion cooling requirements in practical realisations of quantum computing and simulation.
description: 9 pages, 4 figures
Synthesis of aziridines and the functionalisation of the intact ring
Creators: name: Boultwood, Tom
Publisher: name: Imperial College London
Year: 2015

description: Aziridines continue to offer synthetic interest, whilst providing important intermediates in the preparation of a variety of biologically active targets. This thesis describes the preparation of novel functionalised aziridines that offer new complementary reactivity in aziridine functionalisation chemistry. The development of divergent stereospecific methodology to functionalise these aziridines will also be explored, keeping the ring intact during this process. The first preparation of an iodo-aziridine is detailed, achieved via the use of LiCHI2 and imines in a diastereoselective addition-cyclisation protocol. Both aromatic and alkyl iodoaziridines can be accessed in good yields, exclusively as their cis-diastereoisomers. These bench stable functionalised aziridines provide scaffolds for further derivatisation of the intact ring via formation of aziridinyl anions, aziridinyl radicals and aziridinyl metal species. Stereospecific lithiation of alkyl and aryl N-Ts iodoaziridines at low temperature generates an unstabilized aziridinyl lithium species which can be subsequently trapped with a range of carbon and heteroatom electrophiles allowing the exclusive formation of cis-substituted aziridines. Furthermore, aziridinyl radicals can be generated from the N-Ts iodoaziridine via single electron transfer in a radical substitution. The resulting aziridines are accessed predominately as their trans-diastereoisomer, with the reaction proceeding via a planar aziridinyl radical intermediate. The use of transition metal catalysis has also enabled the first cross-coupling of an iodoaziridine, with excellent diastereoselectivity observed in the coupling protocol. The stereochemical outcome at each stage of functionalisation will be fully discussed.