cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dog checking the clay sculpture The Vision of Eof
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 190502 Fine Arts (incl. Sculpture and Painting)
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: I got a bit concerned as the claywork of the sculpture was finished and I thought my dog might take a bite out of the clay snout - he did things like that when he was younger! [A4A Art for Architecture, High McGowanston Studio, Ayrshire, Scotland] This clay sculpture was created of The vision of Eof by sculptor John McKenna ARBS, before moulding at the A4A studio foundry, in Ayrshire. From the mould a full size wax version was made for investing, ready to cast in bronze. The bronze statue was unveiled in 2008 on site on the edge of the town market square in Evesham. The sculptor had won a public art competition held by the Cotswold and Vale Magazine of Evesham around the 2000 millennium, to select by public vote a sculpture using the theme of the legend of Eof. The legend of the founding of Evesham is that while searching for his pigs on the banks of the River Avon, Eof, a swineherd, received a vision of the Virgin Mary. Eof related this vision to Ecgwine (Saint Egwin), Bishop of Worcester. Ecgwine founded the great Evesham Abbey in about 701 AD on the site of the vision. The town's early name 'Eofeshamme' reflects this legend.
Nicotine Alters the Proteome of Two Human Pancreatic Duct Cell Lines
Creators: name: Paulo, Joao A
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Amyloid; Nicotine; Pancreatic Ducts; Pancreatic Neoplasms; Receptors, Nicotinic

description: Context Cigarette smoking is a known risk factor of pancreatic disease. Nicotine - a major cigarette tobacco component - can traffic through the circulatory system and may induce fibrosis and metastasis, hallmarks of chronic pancreatitis and pancreatic adenocarcinoma, respectively. However, at the biomolecular level, particularly in pancreatic research, the effects of nicotine remain unresolved. Methods The effects of nicotine on the proteomes of two pancreatic duct cell lines–an immortalized normal cell line (HPNE) and a cancer cell line (PanC1)- were investigated using mass spectrometry-based proteomics. For each cell line, the global proteomesof cells exposed to nicotine for 24 hrswere compared with untreated cells in triplicate using 6-plex tandem mass tag-based isobaric labeling techniques. Results Over 5,000 proteins were detectedper cell line. Of these, over 900 proteins were differentially abundant with statistical significance (corrected P-value <0.01) upon nicotine treatment, 57 of which were so in both cell lines. Amyloid precursor protein, previously observed to increase expression in pancreatic stellate cells when exposed to nicotine, was also up-regulated in both cell lines.In general, the two cell lines varied in the classes of proteins altered by nicotine treatment, supporting published evidence that nicotine may play different roles in the initiation and progression of pancreatic disease. Conclusions Understanding the underlying mechanisms associating nicotine with pancreatic function is paramount to intervention aiming to retard, arrest, or ameliorate pancreatic disease.

Image: Heat map of 315 proteins that were statistically significant in the HPNE cell line.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Agenesis of Dorsal Pancreas Associated with Periampullary Pancreaticobiliary Type Adenocarcinoma
Creators: name: Sannappa, Raghu M
name: Buragohain, Jadunath
name: Sarma, Dipti
name: Saikia, Uma Kaimal
name: Choudhury, Bipul Kumar
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Adenocarcinoma; Carcinoembryonic Antigen; Carcinoma, Pancreatic Ductal; Pancreas agenesis, dorsal

description: Context Agenesis of the dorsal pancreas is one of the rare congenital malformations of pancreas. The association of agenesis of the dorsal pancreas with pancreatic tumors is extremely rare and only around 9 cases being reported till date. Case report We report a case of a fifty one year old woman with an agenesis of the dorsal pancreas with periampullary pancreaticobiliary adenocarcinoma. She presented with features of obstructive jaundice without pain abdomen or fever. Laboratory data showed conjugated hyperbilirubinemia, raised alkaline phosphatase and impaired glucose tolerance. Ultrasound abdomen showed periampullary mass. MRI abdomen and MRCP demonstrated dorsal agenesis of the pancreas, dilated intra and extra hepatic bile ducts with narrowing of distal CBD with periampullary mass. Pancreatic tumor was considered as preoperative diagnosis, and pancreaticoduodenectomy was performed. Histopathology confirmed pancreaticobiliary type of adenocarcinoma. Conclusion A rare case of dorsal agenesis of the pancreas with periampullary pancreaticobiliary type of adenocarcinoma was presented. Therefore this case therefore merits reference as a rare clinical presentation.

Image: Immunohistochemical staining of poorly differentiated tumor showing positivity for proliferative marker Ki-67.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
All Saints' Church, Sinnington, North Yorkshire
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: The present church of All Saint's in Sinnington is mostly a late Norman building, but numerous fragments of Anglo-Saxon and Norse sculpture work are preserved in the fabric of the church, clearly implying that its origins are much earlier. I believe that the door on the west end of the nave it probably late Saxon, which implies that part of the building is probably pre-Norman. Its location, situated on top of a prominent hill overlooking the village of Sinnington may further suggest its early origins.
Bei der Redaktion eingegangene Neuerscheinungen
Creators: name: Redaktion, Die
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Bd. 20 Nr. 1 (1967): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
LUFTA KUNDËR FALLSIFIKIMIT TË MALLRAVE DHE SHËRBIMEVE, SFIDË E DOGANAVE SHQIPTARE EDHE GJATË PANDEMISË
Creators: name: SULA, Ledia
Publisher: name: Zenodo
Year: 2021

description: The globalization of exchanges, which is characterized by the circulation of goods in an unprecedented speed, unfortunately nourishes a favorable environment for the distribution of counterfeit products on a global scale. Counterfeit products present an amount of more than hundreds of billions of euros, keeping the second place in the criminal activity, after the drug traffic. Initially it is the responsibility of the Customs that are entirely modernized to undertake an uninterrupted, quick and more complex development of the international exchanges, but also to withstand a scam and an organized, multiform and aggressive criminal act. Albania is quite conscious that a stable system of the intellectual property, including the efficient application of the intellectual property rights, is an essential element for the further social progress, for the enhance of the competitiveness of the country, for better conditions in the local employment, etc. It contributes in the creation of optimal conditions for foreign investments and in the process of european integration. According to the last Report of the European Commission in October 2020, (Chapter 29: Customs Union), Albania is moderately prepared in the field of customs union. Limited progress has been made, in particular on improving cash flow control at border crossing points. According to this report, efforts to enforce intellectual property rights have improved. Legislation on customs enforcement of Intellectual Property Rights (IPR) is in line with the EU acquis. In 2019, the import of a total of 23,273 goods that were suspected of violating intellectual property rights was suspended, as well as 4,149 goods destroyed after confirmation received from the property right holder. Among the challenges for the future of Albanian Customs can be mentioned: - Construction of a proper administrative infrastructure within the national institutions involved in ensuring the protection of Intellectual Property. - Installation of the full version of INES + software, which will serve as a database and in processing requests for customs action in electronic format. - Training of GDC staff and increase cooperation at national and international level with other actors involved in the protection of Intellectual Property Rights. - Undertaking public awareness campaigns regarding the importance of IPR.
The Role of Endoscopic Ultrasound in Primary Pancreatic Lymphoma Presented with Acute Pancreatitis: A Case Report
Creators: name: Abedi, Seyed Hassan
name: Ahmadzadeh, Alireza
name: Nikmanesh, Ali
name: Mohammad Alizadeh, Amir Houshang
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Adenocarcinoma; Lymphoma; Pancreas; Pancreatic Neoplasms

description: Context Primary pancreatic lymphoma (PPL) is rare but manageable malignant tumor of the pancreas which may be confused with pancreatic adenocarcinoma. Case report We report a 38 year-old smoker man with IVDA and history of B (inactive carrier), C (Ia genotype) hepatitis and negative for HIV admitted to our hospital because of nausea, vomiting, epigastric and RUQ pain as a result of long period of alcohol consumption. Due to high amount of amylase (480 U/L) and lipase (326 U/L) Pancreatitis was diagnosed. Four days after admission CT was done that showed enhancement a large tumor of the head of the pancreas. Endoscopic ultrasound (EU) revealed diffusely enlarged of pancreas. There was a mixed echoic mass lesion 37-50 mm at the head of pancreas (R/O walled off necrosis) with adhesion to portal vein and SMV. On the other hand the CBD was 9 mm. Abdominal MRI and MRCP for patient was done. The intra-hepatic bile ducts, main hepatic ducts, CHD and CBD were mildly dilated and displaced to the right side by a large lobulated mass (160×112×130 mm) of pancreatic head with low signal intensity on T1W images and high intensity on T2W images. we did EUS-FNA and there was a mixed echotic lesion (38-40 mm) adhered to head of pancreas with invasion to portal vein, SMA and SMV. The diagnosis of pancreatic lymphoma was established by immunohistochemical study and the assessment of the neoplastic cells revealed B cell lymphoma phenotypes. Conclusion Herein we present an interesting 38 year- old man with pancreas head tumor. Primary pancreatic lymphoma is almost never suspected clinically. It is usually diagnosed by imaging and histological methods.

Image: Enlarged pancreas and echoic mass lesion.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Dissociation of Relativistic $^{10}$B Nuclei in Nuclear Track Emulsion
Creators: name: Zaitsev, A. A.
name: Artemenkov, D. A.
name: Bradnova, V.
name: Zarubin, P. I.
name: Zarubina, I. G.
name: Kattabekov, R. R.
name: Kornegrutsa, N. K.
name: Mamatkulov, K. Z.
name: Mitsova, E. K.
name: Neagu, A.
name: Rukoyatkin, P. A.
name: Rusakova, V. V.
name: Sarkisyan, V. R.
name: Stanoeva, R.
name: Haiduc, M.
name: Firu, E.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The structural features of $^{10}$B are studied by analyzing the dissociation of nuclei of this isotope at an energy of 1 A GeV in nuclear track emulsion. The fraction of the $^{10}$B $\to$ 2He + H channel in the charge state distribution of fragments is 78\%. It was determined based on the measurements of fragment emission angles that unstable $^{8}$Be$_{g.s.}$ nuclei appear with a probability of (26 $\pm$ 4)\%, and (14 $\pm$ 3)\% of them are produced in decays of an unstable $^9$B$_{g.s.}$ nucleus. The Be + H channel was suppressed to approximately 1\%.
description: Published as proceedings of The International Session-Conference of SNP PSD RAS "Physics of Fundamental Interactions"
Role of Neoadjuvant Therapy in Management of Pancreatic Cancer
Creators: name: Li, Jia
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Chemoradiotherapy; Neoadjuvant Therapy; Pancreatic Neoplasms

description: Surgery remains the only curative treatment for pancreatic cancer; however, majority of patients present with advanced unresectable disease upon diagnosis. Treatment of nonmetastatic, locally advanced pancreatic cancer (LAPC) continues to require multidisciplinary bimodality or trimodality approach. Neoadjuvant therapies have been investigated for LAPC given its established role in other solid cancers such as breast cancer, gastric cancer, and rectal cancer. This strategy is now moving forward to management of potentially resectable disease as well. This meeting highlight focuses on recent updates on neoadjuvant therapy for both borderline resectable disease and potentially resectable disease, Abstracts #4120, #e15189, #e15226 and #TPS4158 will be discussed.

Image: Yale Cancer Center. New Haven, CT, USA.
description: JOP. Journal of the Pancreas, Vol 15, No 4 (2014): July - p. 280-412
Pancreatic Cancer: New Hopes for Early Detection and a Future Screening Tool?
Creators: name: El-Jurdi, Najla H
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Neuroendocrine Tumors; Pancreas; Pharmacogenetics

description: Given the overall poor prognosis of patients with pancreatic cancer, there has always been an interest in early screening and primary prevention. An abstract presented in ASCO 2014 by Orlowski et al. introduced the potential use of an elevated serum procarboxypeptidase A (PCPA) and high ratios of PCPA to free carboxypeptidase A (FCPA) in enhancing the diagnostic efficacy of pancreatic cancer either alone or with CA19-9 (Abstract #4118).

Image: Screening.
description: JOP. Journal of the Pancreas, Vol 15, No 4 (2014): July - p. 280-412
Archäologische Untersuchungen auf der Wüstung Medefeld bei Bennigsen, Region Hannover
Creators: name: Gärtner, Tobias
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2019

description: Nachrichten aus Niedersachsens Urgeschichte, Bd. 78 (2009): Nachrichten aus Niedersachsens Urgeschichte
All Saints' Church, Sinnington, North Yorkshire
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: The present church of All Saint's in Sinnington is mostly a late Norman building, but numerous fragments of Anglo-Saxon and Norse sculpture work are preserved in the fabric of the church, clearly implying that its origins are much earlier. I believe that the door on the west end of the nave it probably late Saxon, which implies that part of the building is probably pre-Norman. Its location, situated on top of a prominent hill overlooking the village of Sinnington may further suggest its early origins.
Comments on the Article “Management of Suspected Acute Inflammatory Pancreatopathies in a "Real-world" Setting: A Single-Centre Observational Study”
Creators: name: Goyal, Hemant
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Disease Management; Pancreatitis

description: No abstract available.

Image: Mercer University School of Medicine (Macon, GA, USA) logo.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
On the 'Consequences of War' by Peter Paul Rubens
Creators: name: Chmelinová, Katarína
Publisher: name: Quart
Year: 2019

description: Includes a summary in English Zawiera streszczenie w języku polskim
description: Quart, Bd. 31 Nr. 1 (2014): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Cross Branch Feature Fusion Decoder for Consistency Regularization-based Semi-Supervised Change Detection
Creators: name: Xing, Yan
name: Xu, Qi'ao
name: Zeng, Jingcheng
name: Huang, Rui
name: Gao, Sihua
name: Xu, Weifeng
name: Zhang, Yuxiang
name: Fan, Wei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Semi-supervised change detection (SSCD) utilizes partially labeled data and a large amount of unlabeled data to detect changes. However, the transformer-based SSCD network does not perform as well as the convolution-based SSCD network due to the lack of labeled data. To overcome this limitation, we introduce a new decoder called Cross Branch Feature Fusion CBFF, which combines the strengths of both local convolutional branch and global transformer branch. The convolutional branch is easy to learn and can produce high-quality features with a small amount of labeled data. The transformer branch, on the other hand, can extract global context features but is hard to learn without a lot of labeled data. Using CBFF, we build our SSCD model based on a strong-to-weak consistency strategy. Through comprehensive experiments on WHU-CD and LEVIR-CD datasets, we have demonstrated the superiority of our method over seven state-of-the-art SSCD methods.
description: 5 pages, 4 figures, accepted by ICASSP 2024
Omówienie wystawy „Van Gogh: Couleurs du Nord, couleurs du Sud” (Fondation Vincent van Gogh Arles, 7 IV – 31 VIII 2014)
Creators: name: Jarosz, Andrzej
Publisher: name: Quart
Year: 2019

description: Includes a summary in English
description: Quart, Bd. 33 Nr. 3 (2014): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Pancreatic Neuroendocrine Tumor with Extensive Intraductal Invasion of the Main Pancreatic Duct: A Case Report
Creators: name: Kiyonaga, Maki
name: Matsumoto, Shunro
name: Mori, Hiromu
name: Yamada, Yasunari
name: Takaji, Ryo
name: Hijiya, Naoki
name: Yoshizumi, Fumitaka
name: Aramaki, Masanori
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Neuroendocrine Tumors; Pancreas

description: Context Pancreatic neuroendocrine tumors account for only 1-3% of all pancreatic neoplasms and the intraductal invasion of the main pancreatic duct (MPD) is rare. Case report We report a case of a 26-year-old woman with an endocrine tumor of the pancreas extensively invading into the MPD. She presented abdominal pain and her laboratory data showed abnormal liver function. Contrast-enhanced computed tomography demonstrated a well-enhanced mass on the arterial dominant phase in the head of the pancreas. The mass grew within the lumen of the MPD in the body of the pancreas, with dilatation of the upstream MPD. The contrast-enhancement pattern between the main tumor of the head and the intraductal lesion of the body was different. On T2-weighted magnetic resonance (MR) imaging, the pancreatic head lesion showed non homogeneously low signal intensity, while the intraductal lesion of the pancreatic body showed high signal intensity. MR cholangiopancreatography showed obstruction of the MPD in the pancreatic head to body, with dilatation of the upstream MPD. An endocrine tumor or acinar cell carcinoma of the pancreas was considered as preoperative diagnosis, and pancreaticoduodenectomy was performed. As a result, pancreatic endocrine tumor (G2) was confirmed pathologically. Conclusion A rare case of pancreatic neuroendocrine tumor with extensive growth within the MPD was presented. The intraductal extension is a unique growth pattern of nonfunctioning pancreatic neuroendocrine tumor, and the desmoplastic reaction in this tumor may reflect the increased invasiveness.

Image: Histopathological findings (H&E stain). The pancreatic head lesion is comprised of small nests and cords of uniform cells.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Diabetes and Cancer: The Problem of Reverse Causality and Missing Links
Creators: name: Whitcomb, David C
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: Several epidemiology studies have observed that there is a higher than expected association between diabetes mellitus (DM) and pancreatic ductal adenocarcinoma (PDAC). However, because no plausible mechanistic link exists between high glucose levels and carcinogenesis, additional risk factors are likely involved. Evaluating these epidemiologic data has been confounded by difficulty in identifying appropriate control populations and in replicating the demographics and risk found in previous studies. Furthermore, a significant subset of patients developed DM up to 2 years before the detection of cancer, suggesting that the glucose intolerance in these patients is a paraneoplastic syndrome linked to factors released from the tumor rather than typical type 1 or type 2 DM. Indeed, DM is a major co-morbidity of PDAC and is often reversed following resection of the cancer and a major part of the pancreas, while in other cases, pancreatic resection leads to DM. Finally, the DM may be associated with previous acute pancreatitis and/or subclinical chronic pancreatitis, so that the diagnosis of pancreatitis is often missed. The pancreatitis factor is important since the link between pancreatitis and pancreatic cancer is well established and a close temporal link between pancreatitis and diabetes in known. In these cases the primary epidemiology association is between DM and pancreatitis rather, and secondarily, there is a mechanistic association between pancreatitis and PDAC. To date, though, pancreatitis and pancreatogenic DM (Type 3c) has not been adequately assessed in a major epidemiology study. These observations indicate that glucose intolerance is non-specific, that PDAC can cause DM, and that pancreatitis may be an important missing link between DM and PDAC. Thus, new carefully controlled studies are needed to better understand the underlying cause of the association of PDAC with DM.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Chronic Pancreatitis, Type 3c Diabetes, and Pancreatic Cancer Risk
Creators: name: Whitcomb, David C
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: About half of all patients with chronic pancreatitis (CP) develop diabetes mellitus (DM) due to the loss of islet cell mass, not just beta cells as in Type 1 DM (T1DM), or due to insulin resistance, as in Type 2 DM (T2DM). Patients with DM from loss of islets due to pancreatic disease or resection are diagnosed with pancreatogenic or Type 3c DM (T3cDM). Patients with T3cDM also lose counter-regulatory hormones, such as glucagon and pancreatic polypeptide, and experience maldigestion associated with pancreatic exocrine insufficiency. Patients with T3cDM are therefore more susceptible to hypoglycemia and a mismatch (asynchrony) between food ingestion and nutrient absorption. At the same time, the use of incretin therapy is likely useless, since maldigestion leads to the release of higher levels of hind gut hormones, including GLP1. Thus, T3cDM caused by CP or destruction of the islets involves a special class of potential risks and comorbidity that may be overlooked if the CP has not been diagnosed. Further, because CP is also associated with pancreatic ductal adenocarcinoma, better classification of patients with DM is needed to determine if PDAC is associated with DM or with undetected CP that gave rise to T3cDM that was previously misclassified as T1DM to T2DM.

Image: Cathedral of Learning at University of Pittsburgh. Pittsburgh, PA, USA. (Author: Kevin Albright, Wikimedia Commons)
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Region Mixup
Creators: name: Saha, Saptarshi
name: Garain, Utpal
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: I.2.10

description: This paper introduces a simple extension of mixup (Zhang et al., 2018) data augmentation to enhance generalization in visual recognition tasks. Unlike the vanilla mixup method, which blends entire images, our approach focuses on combining regions from multiple images.
description: Published as a Tiny Paper at ICLR 2024
Islet Inflammation: A Causal Link Between Diabetes and Pancreatic Cancer?
Creators: name: Butler, Peter C
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: Type 2 diabetes (T2DM) is characterized hyperglycemia due to impaired insulin secretion and a deficit of pancreatic beta cells in the setting of insulin resistance. Most individuals are able to compensate for insulin resistance by increasing insulin secretion so the genetic basis of T2DM appears to be linked to the underlying mechanisms leading to this abnormal pancreatic islet response to insulin resistance. In support of this, pancreatic islets in T2DM have a specific pathology. The ~65% deficit in beta cells is presumably due to increased beta cell apoptosis, the underlying mechanisms of which include a misfolded protein induced endoplasmic reticulum stress, mitochondrial dysfunction and local release of inflammatory cytokines. It has long been recognized that there is an association between T2DM and pancreatic cancer. One explanation for this is the development of diabetes in relation to pancreatic cancer, when the diagnoses are temporarily related. However there is also an increased risk of pancreatic cancer with long standing T2DM. We propose that a plausible explanation for this association is the consequence of long term exposure of surrounding pancreas to cytokines release by inflamed islets. Further, we speculate that there is a common progenitor cell niche in the pancreas for exocrine and endocrine repair, comparable to that in other gastroenterological organs, repopulating the exocrine and endocrine pancreas. Chronic inflammatory mediated stimulus of such a progenitor would be expected with time, in those with underlying relevant mutations such as KRAS activating, to increase the risk of malignant transformation.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Chironomus undetermined
Creators: name: Armitage, Brian J.
name: Andersen, Trond
name: Giłka, Wojciech
name: Castillo Sánchez, Kayla N.
name: Ríos González, Tomás A.
name: Aguirre, Yusseff P.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Chironomus
Chironomus undetermined

description: Chironomus spp.
Material examined. Panama, Chiriqui Province, Cuenca 102, Renacimiento District, Reserva Privado Landis, Quebrada sin nombre, 1 male, 15–30 December 2021, Malaise trap, leg M. Landis. Chiriqui Province, Cuenca 102, Tierras Altas District, Mount Totumas Cloud Forest and Biological Reserve, Quebrada Norte, 2 males, 26–28 December 2017, Malaise trap, leg B. Armitage & J. Dietrich. Chiriquí Province, Cuenca 108, Gualaca District, Quebrada Grande, 5 males, 27 February 2019, UV light trap, leg Y. Aquirre. Chiriquí Province, Cuenca 108, Boquete District, Quebrada Grande, Valle Escondido, Condo unit 157-G, 3 males, June 2022, UV light trap, leg T.I. Arefina-Armitage. Chiriquí Province, Cuenca 108, Boquete District, Quebrada Jaramillo Abajo, 2 males, 28 November 2018, UV light trap, leg K. Castillo; as previous except 10 males, February–March 2019.
description: Published as part of Armitage, Brian J., Andersen, Trond, Giłka, Wojciech, Castillo Sánchez, Kayla N., Ríos González, Tomás A. & Aguirre, Yusseff P., 2025, The Diptera of Panama. II. A first benchmark for the family Chironomidae, pp. 201-240 in Zootaxa 5613 (2) on page 208, DOI: 10.11646/zootaxa.5613.2.1, http://zenodo.org/record/15224174
GLP-1 Based Therapy and the Exocrine Pancreas: Accelerated Dysplasia and Cancer?
Creators: name: Butler, Peter C
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: Type 2 diabetes (T2DM) is characterized by a deficit in pancreatic beta cell mass with increased beta cell apoptosis. Abnormalities of the exocrine pancreas have also been reported in T2DM, including a decreased overall pancreas size and increased pancreatitis. A promising therapy for T2DM emerged from an old observation that ingested glucose enhances insulin secretion to a greater extent than intravenously infused glucose, an observation termed the incretin effect. The hormone glucagon like peptide one (GLP-1) released from endocrine cells in the gut in response to food ingestion was identified as one of the incretin factors. GLP-1 based therapy has been marked for treatment of T2DM, either as injected GLP-1 mimetics or as orally active inhibitors of the enzyme that degrades endogenously secreted GLP-1 (Dipeptidyl peptidase 4, DPP-4). DPP-4 inhibitors and GLP-1 mimetics are effective at lowering blood glucose in T2DM. The concern as regards the unintended actions of GLP-1 based therapy on the exocrine pancreas was first noted in case reports of pancreatitis in individuals treated with the GLP-1 mimetic exenatide, and this was followed by a caution from the Federal Drug Administration (FDA) based on increased reports of pancreatitis noted in the FDA adverse event reporting system (AERS). Subsequent reports of the actions of GLP-1 on the exocrine pancreas have been controversial. Some, but not all studies, have reported an increase in pancreatic size in animal treated with GLP-1 based therapies. In one human study (of brain dead organ donors) we reported an increase in pancreas weight and pancreatic dysplasia in individuals with T2DM exposed to prior therapy with GLP-1 based therapy (7 DPP-4 inhibitors, 1 GLP-1 mimetic). Others have contested those findings. It is our view that the matter is not resolved and that additional studies are required to establish the safety of this widely prescribed class of drugs.

Image: Gila monster (Heloderma suspectum) venom contains a substance that shares much of its chemistry with human GLP-1. (Author: Blueag9, Wikimedia Commons)
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Napier Pamphlets Box I-II Aldhelm-King Alfred
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 200301 Early English Languages
subject: FOS: Languages and literature
subject: 200503 British and Irish Literature

description: These pamphlets formed part of the collection of Professor Arthur Napier, which was acquired by the University after his death. They are reproduced by kind permission of the Oxford University English Faculty Library. Please note that these are zipped files: in order to open a file, you will need to download it, right-click and choose 'Extract all'.
Napier Pamphlets Box I-II Aldhelm-King Alfred
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 200301 Early English Languages
subject: FOS: Languages and literature
subject: 200503 British and Irish Literature

description: These pamphlets formed part of the collection of Professor Arthur Napier, which was acquired by the University after his death. They are reproduced by kind permission of the Oxford University English Faculty Library. Please note that these are zipped files: in order to open a file, you will need to download it, right-click and choose 'Extract all'.
Ślady modernizmu: krytyczne re-wizje mitologii abstrakcyjnego ekspresjonizmu
Creators: name: Lipiński, Filip
Publisher: name: Quart
Year: 2019

description: Includes a summary in English
description: Quart, Bd. 40 Nr. 2 (2016): Quart. The Quarterly of the Institute of Art History at the University of Wrocław
Thunderfield Castle, Horley, Surrey
Creators: name: Team, Woruldhord Project
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: Photographs of this site, a moat around a flat island probably dating back to Anglo-Saxon times. It is overgrown with trees and only accessible by public footpath round 3/4 of the oval moat structure. There is also an inner moat that is not accessible. Private house(s) established on the site. It is listed in "Anglo-Saxon England" (F Stenton 1943f) as one site where King Athelstan held his council; and as a bequest of King Alfred in Anglo-Saxon Charters, S 1507: http://hwaet.heroku.com/charters?range=1482-1539 However other resources date it back only to the 12th century. Local, unsubstantiated, claims are that King Harold II's army camped here before Hastings. The photos only show the moat and low mound inside, and that is all that is currently accessible.
Role of Signal Dynamics in the Link Between Type 2 Diabetes and Cancer
Creators: name: Osman, Mahasin
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: Epidemiological studies revealed a connection between several types of cancer and type 2 diabetes (T2D), and suggested that T2D is both a symptom and a risk factor of pancreatic cancer. High level of circulating insulin (hyperinsulinemia) associated with obesity has been implicated in promoting aggressive types of cancers. Peripheral insulin resistance, a symptom/risk factor of T2D, pressures pancreatic b-cells to increase insulin secretion, which results in hyperinsulinemia. This in turn, is believed to lead to a poorly understood gradual loss of functional b-cell mass, thus suggesting the existence of a fine-balance and interplay between b-cell function and mass. While the mechanisms of these connections are unclear, the mammalian target of rapamycin complex 1 (mTORC1) pathway has been implicated in controlling b-cell function and mass, and mediating a link between cancer and T2D. However, the mechanism by which the mTOR pathway does so remains unclear. Moreover, incomplete understating of how the pathway is regulated and how it integrates body metabolism has hindered its efficacy as a clinical target. The IQ motif containing GTPase-activating protein 1 (IQGAP1) is a growth factor- and nutrient-sensor that couples cell growth and division, and regulates glucose-stimulated insulin secretion from b-cells. Dysregulation of IQGAP1 is associated in humans with several carcinomas and with T2D. Here we discuss how IQGAP1, through differential interactions with Rho-type of small guanosine triphosphatases (GTPases), acts as a rheostat that fine-tunes the mTORC1 and the mitogen-activated protein kinase (MAPK) signals, and potentially integrates b-cell function and mass with insulin action. Dysfunction of IQGAP1 provides a plausible molecular mechanism for understanding cancer initiation in diabetes, and a potential clinical target for treating both cancer and diabetes with high selectivity.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Cucheb: A GPU implementation of the filtered Lanczos procedure
Creators: name: Aurentz, Jared L.
name: Kalantzis, Vassilis
name: Saad, Yousef
Publisher: name: arXiv
Year: 2024
Subjects: subject: Numerical Analysis (math.NA)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: This paper describes the software package Cucheb, a GPU implementation of the filtered Lanczos procedure for the solution of large sparse symmetric eigenvalue problems. The filtered Lanczos procedure uses a carefully chosen polynomial spectral transformation to accelerate convergence of the Lanczos method when computing eigenvalues within a desired interval. This method has proven particularly effective for eigenvalue problems that arise in electronic structure calculations and density functional theory. We compare our implementation against an equivalent CPU implementation and show that using the GPU can reduce the computation time by more than a factor of 10.
GFP: Lighting Up Life
Creators: name: Chalfie, Martin
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: The great American baseball player Yogi Berra once said: “You can observe a lot by watching.” Unfortunately, before the early 1990s observations in the biological sciences were usually done on dead specimens that were specially prepared and permeabilized to allow entry of reagents to stain cell components. These methods allowed a glimpse of what cells were doing, but they gave a necessarily static view of life, just snapshots in time. GFP and other fluorescent proteins revolutionized the biological sciences because these proteins allowed scientists to look at the inner workings of living cells. GFP can be used to tell where genes are turned on, where proteins are located within tissues, and how cell activities change over time. Once a cell can be seen, it can be studied and manipulated. The story of the discovery and development of GFP also provides a very nice example of how scientific progress is often made: through accidental discoveries, the willingness to ignore previous assumptions and take chances, and the combined efforts of many people. The story of GFP also shows the importance of basic research on non-traditional organisms.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Modulation of Sensory Mechanoreceptor Neurons in Caenorhabditis elegans by Insulin and Other Signals
Creators: name: Chalfie, Martin
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: Gentle touch is sensed in the nematode Caenorhabditis elegans by six touch receptor neurons (TRNs). Transduction requires a heterotrimeric channel comprised of two DEG/ENaC proteins, MEC-4 and MEC-10, in a 2:1 ratio. Touch sensitivity is modulated by several different factors and on at least two different time scales. In the short term repeated stimuli result in two forms of habituation, one involving intrinsic regulation and the other requiring synaptic regulation. In addition long-term affects (resulting after several hours) are produced by vibration, which acts through integrins and other focal adhesion molecules in the TRNs to increase sensitivity and low oxygen, high salt, and entry into the dauer state, which affect neurohormonal regulation by the products of two different insulin genes of the TRNs to reduce sensitivity. These long-term modifications act through the transcription factor DAF-16 to change the amount of surface MEC-4. These changes, which are integrated at several levels within the animal and in the TRNS, allow the animals to respond differently to touch under various environmental conditions and to prioritize sensory signals.

Image: Caenorhabditis elegans, adult hermaphrodite (Author: Bob Goldstein, University of North Carolina (UNC), Chapel Hill, NC, USA. Wikimedia Commons)
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Vasoactive Intestinal Peptide-mediated Gene Therapy for Diabetes
Creators: name: Şanlioğlu, Salih
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: All patients with type 1 diabetes (T1DM) and most patients with type 2 diabetes (T2DM) become insulin dependent due to the progressive nature of the disease, eventually leading to beta-cell loss. The increase in apoptosis, but not the decrease in new islet formation or beta-cell replication, is blamed for the loss of beta-cell mass observed in patients with T2DM. Thus, therapeutic approaches that either interfere with apoptosis of beta cells and/or increase beta-cell mass have the potential not only for managing hyperglycemia but also for reversing disease progression. Vasoactive intestinal peptide (VIP) is a neuropeptide of the secretin family just like GLP1 and PACAP with equipotent insulinotropic effects. More importantly, it is an effective anti-inflammatory agent involved in suppression of Th1 immune response and activation of regulatory T cells for inducing immune tolerance. For this reason, VIP is now considered to be an emerging therapeutic agent for autoimmune diseases such as rheumatoid arthritis, ulcerative colitis, multiple sclerosis, and T1DM. Despite all these advantages, VIP is extremely sensitive to peptidases (DPP-4) present in most tissues. Thus, multiple injections of VIP at high doses are required to observe any therapeutic effect. Contrary to using peptide forms of therapeutic agents, some gene therapy vectors can provide long-term and stable gene expression. Thus, viral and non-viral VIP gene delivery methods have been under development. Despite the successful results obtained from these studies, especially against autoimmune diseases, some limitations of using gene therapy vectors were revealed in recent studies. For example, the clinical efficacy of plasmid DNA transfer is low. Adenoviral vectors only provide transient gene expression due to the antigenic character of adenoviral epitopes. AAV has limited cargo capacity and low transduction efficiency. Compared with other gene therapy vectors, lentiviral vectors appear to be the vector of choice when considering long-term gene expression, transduction efficacy, and safety. Consequently, the testing of the efficacy of lentivirus-mediated VIP gene delivery against diabetes became an essential issue to discuss in experimental animal model of diabetes.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Role and Potential Therapeutic Use of TRAIL in Diabetes
Creators: name: Şanlioğlu, Ahter Dilşad
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: TNF-related apoptosis-inducing ligand (TRAIL) is a TNF superfamily member, defined by its high homology to CD95L/FasL and TNF-alpha. It is known for its strong selective apoptotic effect on many transformed cell lines and tumor cells but not in most normal cell types. TRAIL appears to be a more complex molecule than predicted, with a higher therapeutic potential than previously anticipated. This is mainly because it has 5 different receptors that it can bind to in contrast to other TNF family members with one or two receptors; it is expressed widely in human tissues; and it has anti-inflammatory effects. For instance, type 1 diabetes (T1D) development was exacarbated in non-obese diabetic (NOD) mice when TRAIL function was blocked, and TRAIL-/- C57BL/6 mice developed T1D at a much earlier stage following streptozotocin (STZ) injection, compared to mice which displayed normal TRAIL expression. Furthermore, TRAIL displayed a pro-angiogenic effect in primary human vascular endothelial cells. It also induced survival against the apoptosis triggered by pro-inflammatory cytokines in vascular smooth muscle cells, as well as promoting migration and proliferation. Results from studies aiming to clear out the role of TRAIL in diabetes development suggest a protective role for this molecule on beta cells. TRAIL generally does not induce beta cell apoptosis, plays a protective role in these cells against the apoptotic effects of cytokines such as FasL and TNF-alpha, and its receptors are expressed at a significant level in the pancreatic islets. While TRAIL’s role or potential use in diabetes is investigated in various cell and animal systems by many reasearch groups including ours, it is still not clearly identified. Our previous and current results, which mainly support a protective role for TRAIL, will be discussed comparatively with similar and contradictory results of other groups.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Immunosuppressive and Anti-apoptotic Properties of Pancreatic Islet Derived Stem Cells
Creators: name: Karaöz, Erdal
Publisher: name: JOP. Journal of the Pancreas
Year: 2014
Subjects: Congresses; Diabetes Mellitus; English Abstract; Neoplasms

description: Several studies have been reported on the in vitro expansion of stem cells from pancreatic islet (PI-SCs) cultures and on the differentiation of these SCs into multi-lineage cells. These mesenchymal-type cells which exhibit no hormone expression could then be induced to differentiate into hormone-expressing islet-like cell aggregates. It has been shown that human islet-derived precursor cells (hIPCs) were a type of mesenchymal stem cell (MSC). Newly we and some other research groups showed that nestin-positive progenitor/stem cells isolated from islets of human and murine pancreas have phenotypic markers identical to MSCs from bone marrow and that are able to proliferate and differentiate into insulin-producing cells in vitro. We also searched for the transcripts of Oct-4, Rex-1 and Sox-2, because these genes are generally known to be the master regulators of stem cell renewal and differentiation and were expressed by rat pancreatic islet-derived progenitor/stem cells. Therefore, based on our positive outcomes we called them as pancreatic islet-derived stem cells (PI-SCs). We showed by RT-PCR that the nestin-positive cells in the pancreatic islets express neither the hormones insulin, glucagon, somatostatin, or pancreatic polypeptide, nor the markers of embryonic development of endocrine pancreas. Recent studies also recommend that MSCs possess the dual ability to suppress and/or activate the immune responses depending on stimulus to which they are exposed. In addition, MSCs was shown to induce the production of Treg and it was suggested that they could play a potential role in treatment of autoimmune diseases. We studied the protective role of islet derived stem cells in the apoptosis of beta cells. After co-culture of damaged pancreatic islets with pancreatic islet derived stem cells, the expression of regulatory proteins in apoptosis, like Bcl3, TNIP1 (TNFAIP3 interacting protein 1) and MAPKAPK2, were increased under stress in pancreatic islets (unpublished data). The number of viable cells and insulin secretion capacity were preserved in the co culture with stem cells, whereas necrotic bodies were formed in the absence of the stem cells. Under the light of all these findings, SCs of islets like BM-MSCs might have the immunosuppressive and immunomodulatory roles, anti-apoptotic effects and a key function in the evolvement of type 1 diabetes. Therefore, strategies targeting the islet derived MSCs for the correction of the β-cell loss in type 1 diabetes should be established to prevent the destruction of β-cells.
description: JOP. Journal of the Pancreas, Vol 15, No 5 (2014): September - p. 413-540
Thunderfield Castle, Horley, Surrey
Creators: name: Lee, Stuart
Publisher: name: University of Oxford
Year: 2022
Subjects: Archaeology

description: Photographs of this site, a moat around a flat island probably dating back to Anglo-Saxon times. It is overgrown with trees and only accessible by public footpath round 3/4 of the oval moat structure. There is also an inner moat that is not accessible. Private house(s) established on the site. It is listed in "Anglo-Saxon England" (F Stenton 1943f) as one site where King Athelstan held his council; and as a bequest of King Alfred in Anglo-Saxon Charters, S 1507: http://hwaet.heroku.com/charters?range=1482-1539 However other resources date it back only to the 12th century. Local, unsubstantiated, claims are that King Harold II's army camped here before Hastings. The photos only show the moat and low mound inside, and that is all that is currently accessible.