cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Differential radiosensitivity between synchronous primary and metastatic patient derived head and neck cancer cell lines and the effects of hypofractionation
Creators: name: Tseng, Michelle
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Head and neck
subject: Experimental
subject: Radiobiology
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Primary head and neck cancer is known to be radiosensitive however, once the disease becomes metastatic, it is unclear if the radiosensitivity remains the same. We aim to investigate the difference in intrinsic radiosensitivity and dose...
On the correlation functions of the characteristic polynomials of the sparse hermitian random matrices
Creators: name: Afanasiev, Ievgenii
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider asymptotics of the correlation functions of characteristic polynomials corresponding to random weighted $G(n, \frac{p}{n})$ Erd{\H o}s -- Rényi graphs with Gaussian weights in the case of finite $p$ and also when $p \to \infty$. It is shown that for finite $p$ the second correlation function demonstrates a kind of transition: when $p < 2$ it factorizes in the limit $n \to \infty$, while for $p > 2$ there appears an interval $(-λ_*(p), λ_*(p))$ such that for $λ_0 \in (-λ_*(p), λ_*(p))$ the second correlation function behaves like that for GUE, while for $λ_0$ outside the interval the second correlation function is still factorized. For $p \to \infty$ there is also a threshold in the behavior of the second correlation function near $λ_0 = \pm 2$: for $p \ll n^{2/3}$ the second correlation function factorizes, whereas for $p \gg n^{2/3}$ it behaves like that for GUE. For any rate of $p \to \infty$ the asymptotics of correlation functions of any even order for $λ_0 \in (-2, 2)$ coincide with that for GUE.
description: 32 pages; moved subsection on Grassmann variables to Appendix, replaced the proof of lemma 1 by more elegant one, added some references, corrected typos
Two new species of Spionidae (Annelida: Polychaeta) from Mid-Atlantic Ridge hydrothermal vents
Creators: name: SIGVALDADÓTTIR, Elín
name: DESBRUYÈRES, Daniel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Two new species of polychaetous annelids Prionospio unilamellata sp. nov. and Laonice asaccata sp. nov.
 (Spionidae) are described from samples collected at Mid-Atlantic hydrothermal vent fields close to the Azores Triple
 Junction and in the Snake Pit vent field. These two species are important components of the communities associated with
 active venting. Prionospio unilamellata differs from all other Prionospio species in the form of anterior notopodial lamellae.
 Laonice asaccata differs from other Laonice species by lacking interparapodial pouches.
A Type II Radio Burst without a Coronal Mass Ejection
Creators: name: Su, W.
name: Cheng, X.
name: Ding, M. D.
name: Chen, P. F.
name: Sun, J. Q.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Type II radio bursts are thought to be a signature of coronal shocks. In this paper, we analyze a short-lived type II burst that started at 07:40 UT on 2011 February 28. By carefully checking white-light images, we find that the type II radio burst is not accompanied by a coronal mass ejection, only with a C2.4 class flare and narrow jet. However, in the extreme-ultraviolet (EUV) images provided by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO), we find a wave-like structure that propagated at a speed of $\sim$ 600 km s$^{-1}$ during the burst. The relationship between the type II radio burst and the wave-like structure is in particular explored. For this purpose, we first derive the density distribution under the wave by the differential emission measure (DEM) method, which is used to restrict the empirical density model. We then use the restricted density model to invert the speed of the shock that produces the observed frequency drift rate in the dynamic spectrum. The inverted shock speed is similar to the speed of the wave-like structure. This implies that the wave-like structure is most likely a coronal shock that produces the type II radio burst. We also examine the evolution of the magnetic field in the flare-associated active region and find continuous flux emergence and cancellation taking place near the flare site. Based on these facts, we propose a new mechanism for the formation of the type II radio burst, i.e., the expansion of the strongly-inclined magnetic loops after reconnected with nearby emerging flux acts as a piston to generate the shock wave.
description: 18 pages, 10 figures, accepted for publication in ApJ
Insights into Regulated Ligand Binding Sites from the Structure of ZO-1 Src Homology 3-Guanylate Kinase Module
Creators: name: Fanning, Alan S.
name: Lye, Ming F.
name: Anderson, James M.
name: Lavie, Arnon
name: Su, Ying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Tight junctions are dynamic components of epithelial and endothelial cells that regulate the paracellular transport of ions, solutes, and immune cells. The assembly and permeability of these junctions is dependent on the zonula occludens (ZO) proteins, members of the membrane-associated guanylate kinase homolog (MAGUK) protein family, which are characterized by a core Src homology 3 (SH3)-GUK module that coordinates multiple protein-protein interactions. The structure of the ZO-1 SH3-GUK domain confirms that the interdependent folding of the SH3 and GUK domains is a conserved feature of MAGUKs, but differences in the orientation of the GUK domains in three different MAGUKs reveal interdomain flexibility of the core unit. Using pull-down assays, we show that an effector loop, the U6 region in ZO-1, forms a novel intramolecular interaction with the core module. This interaction is divalent cation-dependent and overlaps with the binding site for the regulatory molecule calmodulin on the GUK domain. These findings provide insight into the previously observed ability of the U6 region to regulate TJ assembly in vivo and the structural basis for the complex protein interactions of the MAGUK family.
Review of the hydrothermal vent shrimp genus Mirocaris, redescription of M. fortunata and reassessment of the taxonomic status of the family Alvinocarididae (Crustacea: Decapoda: Caridea)
Creators: name: KOMAI, Tomoyuki
name: SEGONZAC, Michel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: The hydrothermal vent shrimp genus Mirocaris is reviewed. Morphological comparison between the two nominal
 species in the genus, M. fortunata and M. keldyshi, was made based on the re-examination of the holotype and paratypes of
 Mirocaris fortunata and the paratypes of M. keldyshi. Samples newly collected from various sites on the Mid-Atlantic Ridge
 were also examined. The validity of the genus Mirocaris has been confirmed. However, our study has revealed that the
 supposed morphological characters distinguishing M. fortunata and M. keldyshi do not provide significant taxonomic
 differences and further comparison failed to detect morphological differences between the two taxa. Thus
M. keldyshi is synonymized with M. fortunata, and so there is only one single species in the genus Mirocaris. This supports
 the suggestion by Shank et al. (1999), based on a molecular study, that the two taxa might be conspecific.
A redescription of M. fortunata is provided to better establish the morphology of the species. The clarification led us to
 improve the morphological descriptions of the caridean species associated with vent or seep environments and to reassess
 the relationships among Mirocaris and the other shrimp taxa in the superfamily Bresilioidea. The generic diagnosis of
 Mirocaris is emended. Because a number of presumably apomorphic characters are shared by Mirocaris and other
 alvinocaridid genera, the genus Mirocaris is now assigned to the family Alvinocarididae. The family Mirocarididae is syn-
 onymized with the Alvinocarididae and the diagnosis of this family is emended.
THE CYATHOLAIMIDAE (NEMATODA, CHROMADOROIDEA) OFF THE COAST OF NORTHUMBERLAND
Creators: name: WARWICK, Richard M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Ten species of freeliving marine nematodes belonging to the family Cyatho- laimidae are reported from three stations off the coast of Northumberland (England). Their distribution at these three stations is indicated. Eight species are new, and are described as Longicyatholaimus complexus sp. nov., Paracan- thoncus longicaudatus sp. nov., Paralongicyatholaimus minutus sp. nov., Neotonchus filiformis sp. nov., N. vitius sp. nov., N. votadinii sp. nov., N. interruptus sp. nov. and N. meeki sp. nov.
(4011) William Howatson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Insulin-like Growth Factor-I-stimulated Insulin Receptor Substrate-1 Negatively Regulates Src Homology 2 Domain-containing Protein-tyrosine Phosphatase Substrate-1 Function in Vascular Smooth Muscle Cells
Creators: name: Maile, Laura A.
name: Clemmons, David R.
name: Radhakrishnan, Yashwanth
name: Busby Jr., Walker H.
name: Shen, Xinchun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Vascular smooth muscle cells maintained in normal (5.6 mm) glucose respond to insulin-like growth factor-I (IGF-I) with increased protein synthesis but do not proliferate. In contrast, hyperglycemia alters responsiveness to IGF-I, resulting in increased SHPS-1 phosphorylation and assembly of a signaling complex that enhances MAPK and phosphatidylinositol 3-kinase pathways. Hyperglycemia also reduces the basal IRS-1 concentration and IGF-I-stimulated IRS-1-linked signaling. To determine if failure to down-regulate IRS-1 alters vascular smooth muscle cell (VSMC) responses to IGF-I, we overexpressed IRS-1 in VSMCs maintained in high glucose. These cultures showed reduced SHPS-1 phosphorylation, transfer of SHP-2 to SHPS-1, and impaired Shc and MAPK phosphorylation and cell proliferation in response to IGF-I. In vitro studies demonstrated that SHPS-1 was a substrate for type I IGF receptor (IGF-IR) and that IRS-1 competitively inhibited SHPS-1 phosphorylation. Exposure of VSMC cultures to a peptide that inhibited IRS-1/IGF-IR interaction showed that IRS-1 binding to IGF-IR impairs SHPS-1 phosphorylation in vivo. IRS-1 also sequestered SHP-2. Expression of an IRS-1 mutant (Y1179F/Y1229F) reduced IRS-1/SHP-2 association, and exposure of cells expressing the mutant to the inhibitory peptide enhanced SHPS-1 phosphorylation and SHP-2 transfer. This result was confirmed by expressing an IRS-1 mutant that had both impaired binding to IGF-IR and to SHP-2 IGF-I increased SHPS-1 phosphorylation, SHP-2 association with SHPS-1, Shc MAPK phosphorylation, and proliferation in cells expressing the mutant. We conclude that IRS-1 is an important factor for maintaining VSMCs in the non-proliferative state and that its down-regulation is a component of the VSMC response to hyperglycemic stress that results in an enhanced response to IGF-I.
Temporal dynamics of molluscan assemblages from soft and bioclastic bottoms in the Strait of Gibraltar
Creators: name: RUEDA, Jose L.
name: SALAS, Carmen
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: The temporal dynamics of molluscan assemblages of bioclastic gravels and sand bottoms have been studied
 monthly from October 1993 to September 1995 at four sampling stations in the Bay of Barbate, SW Spain (at the Atlantic
 entrance of the Strait of Gibraltar), between 18 m and 29 m depth. Species richness per month ranged between 20 and 40,
 comparable with or greater than those obtained in other studies from soft bottom assemblages of molluscs in European
 coasts. The strong settlement of the bivalve Chamelea striatula during the first studied year, favoured by the effects of
 dredging in the harbour, decreased the values of diversity of Shannon-Wiener and evenness indices. The values of diversity
 (Shannon-Wiener) ranged between 2-3 bits for the entire community. According to the ANOVA tests, the ecological indices
 did not show significant seasonal trend, with and without taking into account the abundance of C. striatula. In the same way,
 the MDS grouped samples without clear seasonal trends. Nevertheless, ANOSIM analyses indicated for both assemblages:
 (1) significant intra-annual variation between colder (autumn-winter) and warmer (spring-summer) periods for both sampled
 years and (2) significant inter-annual differences. According to the ANOVA and ANOSIM results, the works in the harbour
 influenced significantly both assemblages (with and without the data of C. striatula). Some species, mainly gastropods with
 direct development, showed seasonal and cyclical patterns. The absence of seasonality and annual cycles could be explained
 by (1) the absence of strong seasonal characteristics of the bottom (e.g. seagrass, temperature); (2) the possible influence of
 strong bottom currents, and (3) anthropogenic impact in the area.
An Ultraviolet Chiral Theory of the Top for the Fundamental Composite (Goldstone) Higgs
Creators: name: Cacciapaglia, Giacomo
name: Sannino, Francesco
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce a scalar-less anomaly free chiral gauge theory that serves as natural ultraviolet completion of models of fundamental composite (Goldstone) Higgs dynamics. The new theory is able to generate the top mass and furthermore features a built-in protection mechanism that naturally suppresses the bottom mass. At low energies the theory predicts new fractionally charged fermions, and a number of four-fermion operators that, besides being relevant for the generation of the top mass, also lead to an intriguing phenomenology for the new states predicted by the theory.
description: 5 pages, minor modifications, matches published version
Feeding habits of the peacock wrasse Symphodus tinca (Linnaeus, 1758) (Actinopterygii: Perciformes: Labridae) from Eastern Algeria
Creators: name: BOUGHAMOU, Naima
name: DERBAL, Farid
name: KARA, M. Hichem
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The peacock wrasse Symphodus tinca is an abundant and common species along the coast of Algeria. The aim of this study is to provide qualitative and quantitative information on the feeding strategy and food habits of this species in Eastern Algeria. Digestive tracts of 572 specimens with total length ranged from 4.9 to 31.3 cm, and total weight from 1.41 and 420.11 g, were analyzed. The vacuity index (%VI), the index of relative importance (%IRI) and trophic level (TROPH) were studied. Differences in diet depending on season, fish sex and sexual maturity were also checked by statistical analysis. The average annual coefficient of digestive vacuity was 8.74% (50 empty digestive tracts). This percentage varied over the year, with a maximum during the winter and spring which coincides with the spawning period (March-June). The index of relative importance showed that crustaceans were preferentially consumed, whereas sipunculans and mollusks were secondary preys. According to Spearman rank correlation coefficient (rho), the diet composition was homogenous between season, sex and maturity. However, the proportion of ingested peracarid, particularly amphipods and isopods, was more important in immature than in mature individuals. Symphodus tinca is not only omnivorous, but also generalist- opportunist predator with a preference for invertebrate. Nevertheless, it revealed a trophic specialization toward sipunculans.
title: Is this a subpleural nodule or a mediastinal lymph node? Chest CT in prone position helps to solve the mystery – a case report.
Creators: name: Patel, Dhruv
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Oncology
subject: Mediastinum
subject: Lymph nodes
subject: CT
subject: PET-CT
subject: Localisation
subject: Cancer
subject: Neoplasia

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Be careful of lung malignancy adjacent to Fluorodeoxyglucose(FDG) avid mediastinal sarcoidosis. Usefulness of Computed Tomography (CT) in the prone position for accurate anatomical localisation of pulmonary nodules. Usefulness of Endoscopic...
Effect of Number of Users in Multi-level Coded Caching
Creators: name: Hachem, Jad
name: Karamchandani, Nikhil
name: Diggavi, Suhas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: It has been recently established that joint design of content delivery and storage (coded caching) can significantly improve performance over conventional caching. This has also been extended to the case when content has non-uniform popularity through several models. In this paper we focus on a multi-level popularity model, where content is divided into levels based on popularity. We consider two extreme cases of user distribution across caches for the multi-level popularity model: a single user per cache (single-user setup) versus a large number of users per cache (multi-user setup). When the capacity approximation is universal (independent of number of popularity levels as well as number of users, files and caches), we demonstrate a dichotomy in the order-optimal strategies for these two extreme cases. In the multi-user case, sharing memory among the levels is order-optimal, whereas for the single-user case clustering popularity levels and allocating all the memory to them is the order-optimal scheme. In proving these results, we develop new information-theoretic lower bounds for the problem.
description: 13 pages; 2 figures. A shorter version is to appear in IEEE ISIT 2015
FACTEURS ÉCOLOGIQUES ET CYCLE SEXUEL DE LITTORINA SAXATILIS (OLIVI) (MOLLUSQUES, GASTÉROPODES)
Creators: name: BERGERARD, Joseph
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Unlike other species of Littorina that presents during the year a long period of sexual rest, illustrated by the regression of genital glands, accessory glands, and penis of the male, Littorina saxatilis is known to have reproduction the whole year. It is demonstrated that many populations have an important regression of sexual activity in summer, and that this fact is correlated with the local ecological factors. This must have a repercussion on the densities of populations.
Analogies between optical propagation and heat diffusion: Applications to micro-cavities, gratings and cloaks
Creators: name: Amra, Claude
name: Petiteau, David
name: Zerrad, Myriam
name: Guenneau, Sébastien
name: Soriano, Gabriel
name: Gralak, Boris
name: Bellieud, Michel
name: Veynante, Denis
name: Rolland, Nathalie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A new analogy between optical propagation and heat diffusion in heterogeneous anisotropic media has been proposed recently [S. Guenneau, C. Amra, and D. Veynante, Optics Express Vol. 20, 8207-8218 (2012)]. A detailed derivation of this unconventional correspondence is presented and developed. In time harmonic regime, all thermal parameters are related to optical ones in artificial metallic media, thus making possible to use numerical codes developed for optics. Then the optical admittance formalism is extended to heat conduction in multilayered structures. The concepts of planar micro-cavities, diffraction gratings, and planar transformation optics for heat conduction are addressed. Results and limitations of the analogy are emphasized.
description: 20 pages, 11 figures
(4006) Duncan Lamont
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
Creators: name: Modrich, Paul
name: Liu, Yiyong
name: Fang, Yanan
name: Shao, Hongbing
name: Lindsey-Boltz, Laura
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: At clinically relevant doses, chemotherapeutic SN1 DNA methylating agents induce an ATR-mediated checkpoint response in human cells that is dependent on functional MutSα and MutLα. Deficiency of either mismatch repair activity renders cells highly resistant to this class of drug, but the mechanisms linking mismatch repair to checkpoint activation have remained elusive. In this study we have systematically examined the interactions of human MutSα and MutLα with proteins of the ATR-Chk1 pathway using both nuclear extracts and purified proteins. Using nuclear co-immunoprecipitation, we have detected interaction of MutSα with ATR, TopBP1, Claspin, and Chk1 and interaction of MutLα with TopBP1 and Claspin. We were unable to detect interaction of MutSα or MutLα with Rad17, Rad9, or replication protein A in the extract system. Use of purified proteins confirmed direct interaction of MutSα with ATR, TopBP1, and Chk1 and of MutLα with TopBP1. MutSα-Claspin and MutLα-Claspin interactions were not demonstrable with purified proteins, suggesting that extract interactions are indirect or depend on post-translational modification. Use of a modified chromatin immunoprecipitation assay showed that proliferating cell nuclear antigen, ATR, TopBP1, and Chk1 are recruited to chromatin in a MutLα- and MutSα-dependent fashion after N-methyl-N′-nitro-N-nitrosoguanidine treatment. However, chromatin enrichment of replication protein A, Claspin, Rad17-RFC, and Rad9-Rad1-Hus1 was not detected in these experiments. Although our failure to observe enrichment of the latter activities could be due to sensitivity limitations, these observations may indicate a novel mechanism for ATR activation.
The lattice gluon propagator in renormalizable $ξ$ gauges
Creators: name: Bicudo, P.
name: Binosi, D.
name: Cardoso, N.
name: Oliveira, O.
name: Silva, P. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the SU(3) gluon propagator in renormalizable $R_ξ$ gauges implemented on a symmetric lattice with a total volume of (3.25 fm)$^4$ for values of the guage fixing parameter up to $ξ=0.5$. As expected, the longitudinal gluon dressing function stays constant at its tree-level value $ξ$. Similar to the Landau gauge, the transverse $R_ξ$ gauge gluon propagator saturates at a non-vanishing value in the deep infrared for all values of $ξ$ studied. We compare with very recent continuum studies and perform a simple analysis of the found saturation with a dynamically generated effective gluon mass.
description: 6 pages, 4 figures
title: A Rare Case of Metastatic Malignant Mesothelioma in the Inter-atrial Septum.
Creators: name: Patel, Dhruv
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Oncology
subject: Nuclear medicine
subject: PET-CT
subject: CT
subject: Molecular imaging
subject: Neoplasia
subject: Metastases

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Presentation of an extremely rare condition for...
Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes
Creators: name: Harden, T. Kendall
name: Gresset, Aurelie
name: Sondek, John
name: Hicks, Stephanie N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and mostly disordered X/Y linker inserted within the catalytic domain. Release of this auto-inhibition is driven by electrostatic repulsion between the plasma membrane and the electronegative X/Y linker. In contrast, PLC-γ isozymes (PLC-γ1 and -γ2) are structurally distinct from other PLCs because multiple domains are present in their X/Y linker. Moreover, although many tyrosine kinases directly phosphorylate PLC-γ isozymes to enhance their lipase activity, the underlying molecular mechanism of this activation remains unclear. Here we define the mechanism for the unique regulation of PLC-γ isozymes by their X/Y linker. Specifically, we identify the C-terminal SH2 domain within the X/Y linker as the critical determinant for auto-inhibition. Tyrosine phosphorylation of the X/Y linker mediates high affinity intramolecular interaction with the C-terminal SH2 domain that is coupled to a large conformational rearrangement and release of auto-inhibition. Consequently, PLC-γ isozymes link phosphorylation to phospholipase activation by elaborating upon primordial regulatory mechanisms found in other PLCs.
(4007) Ellen Hall Rogers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
Creators: name: Qian, Shu Bing
name: Patterson, Cam
name: Zhang, Xingqian
name: Yewdell, Jonathan W.
name: Bennink, Jack R.
name: Sun, Jun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Balanced protein synthesis and degradation are crucial for proper cellular function. Protein synthesis is tightly coupled to energy status and nutrient levels by the mammalian target of rapamycin complex 1 (mTORC1). Quality of newly synthesized polypeptides is maintained by the molecular chaperone and ubiquitin-proteasome systems. Little is known about how cells integrate information about the quantity and quality of translational products simultaneously. We demonstrate that cells distinguish moderate reductions in protein quality from severe protein misfolding using molecular chaperones to differentially regulate mTORC1 signaling. Moderate reduction of chaperone availability enhances mTORC1 signaling, whereas stress-induced complete depletion of chaperoning capacity suppresses mTORC1 signaling. Molecular chaperones regulate mTORC1 assembly in coordination with nutrient availability. This mechanism enables mTORC1 to rapidly detect and respond to environmental cues while also sensing intracellular protein misfolding. The tight linkage between protein quality and quantity control provides a plausible mechanism coupling protein misfolding with metabolic dyshomeostasis.
Additional file 1 of Translation, cultural adaptation and validation of the Somatic Symptom Scale-8 (SSS-8) for the Brazilian Portuguese language
Creators: name: Pollo, Camila Fernandes
name: Meneguin, Silmara
name: Miot, Hélio Amante
name: de Oliveira, César
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Hematology

description: Additional file 1. Somatic Symptom Scale-8 (SSS-8-BRA).
Multifunctional Nanoparticles Delivering Small Interfering RNA and Doxorubicin Overcome Drug Resistance in Cancer
Creators: name: Bathula, Surendar Reddy
name: Huang, Leaf
name: Li, Jun
name: Chen, Yunching
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Drug resistance is a major challenge to the effective treatment of cancer. We have developed two nanoparticle formulations, cationic liposome-polycation-DNA (LPD) and anionic liposome-polycation-DNA (LPD-II), for systemic co-delivery of doxorubicin (Dox) and a therapeutic small interfering RNA (siRNA) to multiple drug resistance (MDR) tumors. In this study, we have provided four strategies to overcome drug resistance. First, we formed the LPD nanoparticles with a guanidinium-containing cationic lipid, i.e. N,N-distearyl-N-methyl-N-2-(N′-arginyl) aminoethyl ammonium chloride, which can induce reactive oxygen species, down-regulate MDR transporter expression, and increase Dox uptake. Second, to block angiogenesis and increase drug penetration, we have further formulated LPD nanoparticles to co-deliver vascular endothelial growth factor siRNA and Dox. An enhanced Dox uptake and a therapeutic effect were observed when combined with vascular endothelial growth factor siRNA in the nanoparticles. Third, to avoid P-glycoprotein-mediated drug efflux, we further designed another delivery vehicle, LPD-II, which showed much higher entrapment efficiency of Dox than LPD. Finally, we delivered a therapeutic siRNA to inhibit MDR transporter. We demonstrated the first evidence of c-Myc siRNA delivered by the LPD-II nanoparticles down-regulating MDR expression and increasing Dox uptake in vivo. Three daily intravenous injections of therapeutic siRNA and Dox (1.2 mg/kg) co-formulated in either LPD or LPD-II nanoparticles showed a significant improvement in tumor growth inhibition. This study highlights a potential clinical use for the multifunctional nanoparticles with an effective delivery property and a function to overcome drug resistance in cancer. The activity and the toxicity of LPD- and LPD-II-mediated therapy are compared.
Closing the detection loophole in tripartite Bell tests using the W state
Creators: name: Pal, Karoly F.
name: Vertesi, Tamas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the problem of closing the detection loophole in three-qubit Bell tests, the experimentally most relevant case beyond the usual bipartite scenario, and show that the minimal detection efficiencies required can be considerably lowered compared to the two-qubit case. The lowest reported detection efficiency thresholds for two and three qubits so far are $\sim66.7\%$ and $60\%$, respectively. Using the three-qubit W state and a 3-setting Bell inequality, we beat these thresholds and with an 8-setting Bell inequality we reach $50.13\%$. We also investigate generic three-qubit states which allow us to attain a detection efficiency of $50\%$ in a 4-setting Bell test. We conjecture that the limit of $50\%$ is unbeatable using three-qubit states and any number of measurements.
description: 10 pages, 1 figure, 2 tables
Myosin X Regulates Sealing Zone Patterning in Osteoclasts through Linkage of Podosomes and Microtubules
Creators: name: Lee, Beth S.
name: Cheney, Richard E.
name: McMichael, Brooke K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Osteoclasts use actin-rich attachment structures in place of focal adhesions for adherence to bone and non-bone substrates. On glass, osteoclasts generate podosomes, foot-like processes containing a core of F-actin and regulatory proteins that undergo high turnover. To facilitate bone resorption, osteoclasts generate an actin-rich sealing zone composed of densely packed podosome-like units. Patterning of both podosomes and sealing zones is dependent upon an intact microtubule system. A role for unconventional myosin X (Myo10), which can bind actin, microtubules, and integrins, was examined in osteoclasts. Immunolocalization showed Myo10 to be associated with the outer edges of immature podosome rings and sealing zones, suggesting a possible role in podosome and sealing zone positioning. Further, complexes containing both Myo10 and β-tubulin were readily precipitated from osteoclasts lysates. RNAi-mediated suppression of Myo10 led to decreased cell and sealing zone perimeter, along with decreased motility and resorptive capacity. Further, siRNA-treated cells could not properly position podosomes following microtubule disruption. Osteoclasts overexpressing dominant negative Myo10 microtubule binding domains (MyTH4) showed a similar phenotype. Conversely, overexpression of full-length Myo10 led to increased formation of podosome belts along with larger sealing zones and enhanced bone resorptive capacity. These studies suggest that Myo10 plays a role in osteoclast attachment and podosome positioning by direct linkage of actin to the microtubule network.
Complete collisions approximation to the Kadanoff-Baym equation: a first--principles implementation
Creators: name: Sangalli, D.
name: Marini, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We show carriers dynamics on bulk Silicon in the sub pico-second time scale. The results are obtained from a first-principles implementation of the the Kadanoff-Baym equations within the generalized Baym-Kadanoff ansatz and the complete collision approximation. The resulting scattering term is similar to the scattering described within the semi-classical Boltzmann equation.
description: 5 pages, 3 figures, supplementary material 1 video
(4004) Samuel Price
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis
Creators: name: Runge, Mason
name: Szyndralewiez, Cédric
name: Madamanchi, Nageswara R.
name: Molnar, Kimberly C.
name: Vendrov, Aleksandr E.
name: Runge, Marschall S.
name: Niu, Xi Lin
name: Page, Patrick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The intracellular signaling events by which NADPH oxidase-generated reactive oxygen species (ROS) modulate vascular smooth muscle cell (VSMC) function and atherogenesis are yet to be entirely elucidated. We previously demonstrated that NADPH oxidase deficiency decreased atherosclerosis in apoE−/− mice and identified adhesion protein CD44 as an important ROS-sensitive gene expressed in VSMC and atherosclerotic lesions. Here, we examined the molecular mechanisms by which NADPH oxidase-generated ROS regulate the expression of CD44 and its principal ligand, hyaluronan (HA), and how CD44-HA interaction affects VSMC proliferation and migration and inflammatory gene expression in apoE−/− mice aortas. Thrombin-induced CD44 expression is mediated by transcription factor AP-1 in a NADPH oxidase-dependent manner. NADPH oxidase-mediated ROS generation enhanced thrombin-induced HA synthesis, and hyaluronan synthase 2 expression in VSMC. Hyaluronidase, which generates low molecular weight HA (LMW-HA), is induced in VSMC in a NADPH oxidase-dependent manner and LMW-HA stimulated ROS generation and cell proliferation in wild-type but not p47phox−/− VSMC, effects that were enhanced by thrombin pretreatment. Haptotactic VSMC migration toward HA was increased by thrombin in a CD44-dependent manner. HA expression in atherosclerotic lesions and plasma-soluble CD44 and HA levels were higher in apoE−/− compared with apoE−/−/p47phox−/− mice. HA-regulated pro-inflammatory gene expression was higher in apoE−/− than apoE−/−/p47phox−/− mouse aortas. GKT136901, a specific inhibitor of Nox1- and Nox4-containing NADPH oxidase activity, attenuated ROS generation and atherosclerosis and decreased CD44 and HA expression in atherosclerotic lesions. Together, these data suggest that increased CD44 and HA expression and CD44-HA-dependent gene regulation may play a role in atherosclerosis stimulated by NADPH oxidase activation.
BENTHIC COMMUNITIES OF BILBAO HARBOR AND ENVIRONS (NORTHERN SPAIN)
Creators: name: Rallo, A.
name: Gorostiaga, J. M.
name: Saiz, J. I.
name: Isasi, I.
name: Limia, J. M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract
Filling transitions on rough surfaces: inadequacy of Gaussian surface models
Creators: name: Dufour, Renaud
name: Semprebon, Ciro
name: Herminghaus, Stephan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We present numerical studies of wetting on various topographic substrates, including random topographies. We find good agreement with recent predictions based on an analytical interface-displacement-type theory \cite{Herminghaus2012, Herminghaus2012a}. The phase diagrams are qualitatively as predicted, but differently in this study the critical points are found to lie within the physical parameter range (i.e., at positive contact angle) in all cases studied. Notably, it is corroborated that Gaussian random surfaces behave qualitatively different from all non-Gaussian topographies investigated, exhibiting a qualitatively different phase diagram. This shows that Gaussian random surfaces must be used with great care in the context of wetting phenomena.
Nickel Ions Inhibit Histone Demethylase JMJD1A and DNA Repair Enzyme ABH2 by Replacing the Ferrous Iron in the Catalytic Centers
Creators: name: Costa, Max
name: Yamane, Kenichi
name: Zhang, Yi
name: Giri, Nitai Charan
name: Chen, Haobin
name: Maroney, Michael
name: Zhang, Ronghe
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Iron- and 2-oxoglutarate-dependent dioxygenases are a diverse family of non-heme iron enzymes that catalyze various important oxidations in cells. A key structural motif of these dioxygenases is a facial triad of 2-histidines-1-carboxylate that coordinates the Fe(II) at the catalytic site. Using histone demethylase JMJD1A and DNA repair enzyme ABH2 as examples, we show that this family of dioxygenases is highly sensitive to inhibition by carcinogenic nickel ions. We find that, with iron, the 50% inhibitory concentrations of nickel (IC50 [Ni(II)]) are 25 μm for JMJD1A and 7.5 μm for ABH2. Without iron, JMJD1A is 10 times more sensitive to nickel inhibition with an IC50 [Ni(II)] of 2.5 μm, and approximately one molecule of Ni(II) inhibits one molecule of JMJD1A, suggesting that nickel causes inhibition by replacing the iron. Furthermore, nickel-bound JMJD1A is not reactivated by excessive iron even up to a 2 mm concentration. Using x-ray absorption spectroscopy, we demonstrate that nickel binds to the same site in ABH2 as iron, and replacement of the iron by nickel does not prevent the binding of the cofactor 2-oxoglutarate. Finally, we show that nickel ions target and inhibit JMJD1A in intact cells, and disruption of the iron-binding site decreases binding of nickel ions to ABH2 in intact cells. Together, our results reveal that the members of this dioxygenase family are specific targets for nickel ions in cells. Inhibition of these dioxygenases by nickel is likely to have widespread impacts on cells (e.g. impaired epigenetic programs and DNA repair) and may eventually lead to cancer development.
title: Electronic Skin Brachytherapy with Elekta Esteya: Technique and Early Experience
Creators: name: Gorayski, Peter
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Radiation therapy / Oncology
subject: Ultrasound
subject: Soft tissues / Skin
subject: Head and neck
subject: Extremities
subject: Radiotherapy techniques

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To describe the early experience and technique of Australia’s first Elekta Esteya® electronic skin brachytherapy (EB) unit. To give an overview of the equipment and quality assurance processes in place atour...
(4005) Eliza Bull
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The sea slug genus Limacia Müller, 1781 (Mollusca: Gastropoda: Heterobranchia) in Europe
Creators: name: CABALLER GUTIÉRREZ, Manuel
name: ALMÓN PAZOS, Bruno
name: PÉREZ DIESTE, Jacinto
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The study of biodiversity is often hindered by the existence of complexes of morphologically similar species. However, most of the times, the so-called cryptic species are, indeed, distinguishable if the adequate characters are compared. There are 6 accepted species of the genus Limacia Müller, 1781 in the world, but only one of them, Limacia clavigera (O. F. Müller, 1776), is known in Europe. In September 2010, during the course of a regular biodiversity survey in the north east coast of Spain, a small polycerid was captured and misidentified with L. clavigera. This animal is described as a new species in this paper, and discussed with L. clavigera and with its other Atlantic congener, Limacia annulata Vallès, Valdés & Ortea, 2000. In addition, the taxonomic history of Limacia is summarized, the rest of the species of the genus are compared, some potentially controversial cases are analysed and new data are given on the morphology of the spicules of the types of L. annulata.
Temperature dependent formation-time approach for $Υ$ suppression at energies available at the CERN Large Hadraon Collider
Creators: name: Ganesh, S.
name: Mishra, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present here a comprehensive model to describe the bottomonium suppression data obtained from the CERN Large Hadron Collider (LHC) at center-of-mass energy of $\sqrt{s_{NN}}=2.76$ TeV. We employ a quasiparticle model (QPM) equation of state for the quark-gluon plasma (QGP) expanding under Bjorken's scaling law. The current model includes the modification of the formation time based on the temperature of the QGP, color screening during bottomonium production, gluon induced dissociation and collisional damping due to the imaginary part of the potential between the $b\bar b$ pair. We propose a method for determining the temperature-dependent formation time of bottomonia using the solution of the time-independent Schrödinger equation and compare it with another approach based on time-dependent Schrödinger wave equation simulation. We find that these two independent methods based on different axioms give similar results for the formation time. Cold nuclear matter effects and feed-down from higher resonance states of $Υ$ have also been included in the present work. The suppression of the bottomonium states at mid rapidity is determined as a function of centrality. The results compare closely with the recent centrality-dependent suppression data at the energies available at the CERN LHC in the mid rapidity region.
description: 14 pages, 14 figures. Figs. 10, 11 and 13 include shading in published version, but not in arxiv version due to file size limitations. Technical content is exactly the same. arXiv admin note: substantial text overlap with arXiv:1402.1560
A new Tetranchyroderma species (Gastrotricha, Macrodasyida, Thaumastodermatidae) from the Canary Islands (Spain)
Creators: name: TODARO, M. Antonio
name: ANCONA, Patrizia
name: MARZANO, Alessandra
name: GALLO DADDABBO, Maria
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Shallow sublittoral sediment collected from Tenerife (Canary Islands, Spain) yielded several specimens of an
 undescribed thaumastodermatid gastrotrich species along with some specimens of Paraturbanella teissieri and one
 unidentifiable specimen belonging to the genus Crasiella. The paper deals with the description of Tetranchyroderma
 canariense sp. nov. The new species, which appears closely allied with T. thysanogaster, Tetranchyroderma sp. 4 and
 Tetranchyroderma sp. 5 (Valbonesi & Luporini 1984), is characterized by: 1. a complete cuticular covering made up of
 tetrancres, that are larger on the head and rear trunk region; 2. caudal pedicles each made up of two adhesive tubes; 3. up to
 10 anterior adhesive tubes; up to 20 ventrolateral adhesive tubes per side, and two clusters of ventral adhesive tubes of 4
 tubes each, located in the posterior trunk region. This represents the first record of marine Gastrotricha from the Canary
 Archipelago and the second marine gastrotrich species from Spain.