cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of The role of partners, parents and friends in shaping young women’s reproductive choices in Peri-urban Nairobi: a qualitative study
Creators: name: Zinke-Allmang, Anja
name: Bhatia, Amiya
name: Gorur, Krittika
name: Hassan, Rahma
name: Shipow, Amy
name: Ogolla, Concilia
name: Keizer, Kees
name: Cislaghi, Beniamino
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Participant characteristics.
Outcrop analogues for methane hydrate habitats, East Coast, New Zealand
Creators: name: Field, BD
Publisher: name: GNS Science
Year: 2015

description: Modern methane hydrates occur in the offshore part of the Hikurangi margin, and this report outlines some potential outcrop analogues for them. Outcrop analogues are present for: methane conduits (as concretions); methane vents (as bioherms); sandstone reservoirs of various deepwater facies; and as fine-grained “reservoir” units. Analogues covering a wide range of ages are present, though this report focuses more on Neogene examples — the range in ages provides a range of burial depths and hence burial compaction and diagenesis to match the most likely offshore hydrate settings. Potential analogues are described for slope channel units, levee-overbank deposits, canyon and channel units, fan complexes and turbidite lobes, ponded turbidites, fine-grained units, tuffaceous units and fractured units. There are many more potential analogues that have not been described in this report; only some of the main, well-known analogues are mentioned. Many faults and some structural zones that are complexly deformed and fractured are also available for study, as potential analogues for hydrate habitats and fluid migration during hydrate dissociation. There is little rock property data available specifically for hydrate habitats in New Zealand, but the mercury capillary injection data available for some East Coast outcrops provides insights into pore diameters, ranging from 0.02 µm to about 1 µm; this range suggests sediments will likely offer a range of hydrate habitats in the offshore. Further work should include tabulation of parameters for the habitats of modern hydrates on the Hikurangi margin, and detailed studies of specific, high-priority analogues in outcrop.
Additional file 1 of White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta- analysis
Creators: name: Raghavan, Shailaja
name: Abu Alhaija, Elham S.
name: Duggal, Mandeep Singh
name: Narasimhan, Srinivasan
name: Al-Maweri, Sadeq Ali
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
The Association Between the Home Numeracy Environment and Early Math Skills: Math Language as a Moderator
Creators: name: King, Yemimah
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Early childhood education

description: A number of studies provide evidence that the home numeracy environment (HNE) is important for the development of early numeracy skills. There is also evidence that preschoolers understanding of math language is a strong predictor of numeracy skills. However, there is limited research on the role of math language knowledge in the relation between the HNE and early numeracy skills. The purpose of this study was to investigate the relation between different aspects of the HNE (direct vs. indirect numeracy activities) and numeracy skills while considering math language as a moderator. Participants included 125 children between 3.01 to 5.17 years (M = 4.09) and their parents. Parents reported on the frequency of engaging children in home numeracy activities. Children were assessed in the fall and spring of their preschool year on their numeracy skills and math language knowledge. Hierarchical multiple regressions were conducted to test if prior math language knowledge would moderate the relation between each component of the HNE (indirect and direct numeracy activities) and later numeracy skills. Results indicate that math language was not a moderator of these relations. However, supplemental analyses suggest that math language mediates the relation between direct HNE and numeracy skills. These findings provide evidence that the relation between the direct HNE and early numeracy may be explained by preschooler’s math language knowledge.
Infektiologie: Neue Meldepflichten beachten
Creators: name: Diercke, Michaela
name: Buda, Silke
name: Weiß, Bettina
name: Frank, Christine
name: Gilsdorf, Andreas
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: 610 Medizin

description: Die im Mai in Kraft getretene IfSG-Meldepflicht-Anpassungsverordnung berücksichtigt unter anderem die zunehmende Verbreitung von Carbapenem-resistenten Erregern und vektorübertragenden Arboviren.
Supplemental Material, sj-docx-1-ear-10.1177_01455613211028086 - Multiple Warthin Tumors With Epithelial–Myoepithelial Carcinoma of the Ipsilateral Parotid Gland: A Case Report
Creators: name: Sha, Tong
name: Yu, Yang
name: Liu, Kang
name: Sun, Bin
name: Zhang, Wei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Otorhinolaryngology

description: Supplemental Material, sj-docx-1-ear-10.1177_01455613211028086 for Multiple Warthin Tumors With Epithelial–Myoepithelial Carcinoma of the Ipsilateral Parotid Gland: A Case Report by Tong Sha, Yang Yu, Kang Liu, Bin Sun and Wei Zhang in Ear, Nose & Throat Journal
The Relationship Between Vocabulary and Reading Comprehension in Third Grade Students Who Are English Language Learners and Reading Below Grade Level
Creators: name: Boyer, Kelsey
Publisher: name: Maryland Shared Open Access Repository
Year: 2017
Subjects: subject: Vocabulary
subject: English Language Learner
subject: Reading Comprehension
subject: Education -- Research papers (Graduate).

description: The purpose of this study was to determine if direct vocabulary instruction would lead to increased reading comprehension in third grade students who were English Language Learners reading below grade level. The measurement tool used in this study was the Fountas and Pinnell Benchmark Assessment System, Third Edition. This study used a pretest and posttest to measure growth in reading comprehension. The growth rate of comprehension was higher in students after they received direct vocabulary instruction. This study utilized a variety of strategies and techniques discovered through a review of literature on vocabulary acquisition. The more words that students know and understand through vocabulary instruction, the more likely they are to comprehend what they have read. There are growing numbers of English Language Learners in classrooms across the country and therefore research focusing on the impact of vocabulary instruction on the reading comprehension of these students should continue. Data gained from this research can be used by educators to support the reading comprehension of English Language Learners in their schools.
Additional file 1 of Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome
Creators: name: Mullin, Lindsay J.
name: Rutsohn, Joshua
name: Gross, Julia L.
name: Caravella, Kelly E.
name: Grzadzinski, Rebecca L.
name: Weisenfeld, Leigh Anne
name: Flake, Lisa
name: Botteron, Kelly N.
name: Dager, Stephen R.
name: Estes, Annette M.
name: Pandey, Juhi
name: Schultz, Robert T.
name: St. John, Tanya
name: Wolff, Jason J.
name: Shen, Mark D.
name: Piven, Joseph
name: Hazlett, Heather C.
name: Girault, Jessica B.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1.
Synthesis and Structural Studies of Donor-Bridge-Acceptor Complexes Based on Co(III)(cyclam) Acetylides
Creators: name: Banziger, Susannah Dawn Cox
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Inorganic chemistry not elsewhere classified

description: Obtaining a greater understanding of photo-induced electron-transfer (PET) processes is key to synthesizing photovoltaic materials with enhanced efficiency. Gaining knowledge about the structure property relationship in photo-active donor-bridge-acceptor (D-B-A) dyads will help to optimize electronic and photoelectronic materials. Metal acetylide complexes have attracted increasing interest for their potential applications as building blocks for electronic and photoelectronic materials. Their unique υ(C≡C) (2000-2100 cm-1) allows for selective excitation, making them an appealing target for attenuating PET processes across a metal acetylide backbone. The following topics will be discussed: i.) an overview of M(cyclam′) alkynyl chemistry, where M = Cr, Fe, Co, or Ni, with a focus on reactivity and spectroscopy, ii.) selective synthesis of dissymmetric species, utilizing a CoIII(cyclam) (1,4,8,11-tetraazacyclotetradecane) alkynyl bridge, iii) synthesis and characterization of metal alkynyl D-B-A dyads trans- [R'2N-4-C6H4C2-CoIII(cyclam)-Cn-NAPR]+ (n = 2 or 4), where the chromophore acceptor is NAPiPr (N-isopropyl-1,8-napthalimide) and the putative donor is -C6H4-4-NR'2 (R' = Me or Ph-4-OMe), iv.) design and synthesis of D-B-A derivatives, alter NAPR (R = mesityl, methyl, 1-ethylpropyl, 2-ethylhexyl, or octyl) to tune reactivity and crystallinity, v.) electronic and spectroscopic influence the bridging center on A, and vi.) effect of η2 coordination of MX2 (MX2 = CuCl2 or Ag(NO3)2) to the alkyne bridge on electron transfer.
Risiko für psychische Erkrankungen in Städten
Creators: name: Gruebner, Oliver
name: Rapp, Michael A.
name: Adli, Mazda
name: Kluge, Ulrike
name: Galea, Sandro
name: Heinz, Andreas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: 610 Medizin

description: Hintergrund: Mehr als die Hälfte der Weltbevölkerung lebt derzeit in Städten, und es ist ein zunehmender Trend zur Urbanisierung zu verzeichnen. Das Leben in den Städten geht einher mit einer erhöhten Bevölkerungsdichte, Verkehrslärm und Umweltverschmutzung, aber zugleich mit einem besseren Zugang zur Gesundheitsversorgung und anderen Ressourcen. Methode: Die Arbeit basiert auf einer selektiven Literaturrecherche zu den Risikofaktoren für psychische Erkrankungen in urbanen Zentren. Ergebnisse: Studien zeigen, dass das Risiko für bedeutsame psychiatrische Erkrankungen in Städten generell höher ist als in ländlichen Gebieten. Epidemiologische Studien bestätigen, dass Menschen, die in Städten aufwuchsen, ein höheres Schizophrenierisiko haben. Allerdings sind Korrelationen keine Kausalerklärungen, denn das Leben in Armut kann zu einer geringeren psychischen Gesundheit führen, wie auch umgekehrt Beeinträchtigungen der psychischen Gesundheit zur Verarmung beitragen können. Soziale Isolation und Diskriminierung sowie Armut in der Nachbarschaft tragen zu psychischen Belastungen bei, allerdings ist bisher wenig über die spezifischen Wechselwirkungen zwischen diesen Faktoren und der baulichen Struktur der Städte bekannt. Schlussfolgerung: Weitere Erkenntnisse zu den Wechselwirkungen zwischen der räumlich heterogenen Verteilung von Ressourcen in der Nachbarschaft und sozial-ökologischen Faktoren sind nötig und erfordern interdisziplinäre Forschung.
Fallbericht: Ein möglicher Fallstrick in der akuten Differenzialdiagnose einer bakteriellen Meningitis
Creators: name: Weigl, Lorenz B.
name: Fiedler, Christian
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: Meningitis
subject: Differenzialdiagnose
subject: bakterielle Meningitis
subject: 610 Medizin

description: Aktuelle Kommentare in Leitlinien zeigen, dass es bei akuten bakteriellen Meningitis-Erkrankungen nicht in jedem Fall gelingt aus einer Liquorprobe einen mikroskopischen oder kulturellen Erregernachweis zu erzielen.1,2 Dies gilt insbesondere, aber nicht ausschließlich,2 für Fälle mit antibiotischer Vorbehandlung.3 Im vorgestellten Fall erwies sich nicht der mangelnde Erregernachweis als das grundsätzliche Problem, sondern unterschiedliche labordiagnostische Befunde. Aufgrund einer durch das Gesundheitsamt gezielt veranlassten Reevaluation des mikroskopischen Präparates, konnte der korrekte Befund ermittelt werden, welcher sich später auch kulturell bestätigen ließ. Zudem wird die Arbeit des Gesundheitsamtes aufgezeigt, die notwendig war, um beiden differentialdiagnostisch im Raum stehenden invasiven bakteriellen Erkrankungen gerecht zu werden.
Auxin-Induced Actin Cytoskeleton Rearrangements Require Auxin Resistant 1
Creators: name: Arieti, Ruth S
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified
Plant cell and molecular biology
Plant physiology
Plant developmental and reproductive biology
Plant biology not elsewhere classified

description: The actin cytoskeleton is required for cell expansion and is implicated in cellular responses to the plant growth hormone auxin. However, the molecular and cellular mechanisms that coordinate auxin signaling, cytoskeletal remodeling, and cell expansion are poorly understood. Previous studies have examined actin cytoskeleton responses to long-term auxin treatment, but plants respond to auxin over short timeframes, and growth changes within minutes of exposure to the hormone. To correlate actin arrays with degree of cell expansion, we used quantitative imaging tools to establish a baseline of actin organization, as well as of individual filament behaviors in root epidermal cells under control conditions and after treatment with a known inhibitor of root growth, the auxin indole-3-acetic acid (IAA). We found that cell length was highly predictive of actin array in control roots, and that short-term IAA treatment stimulated denser, more longitudinal, and more parallel arrays by inducing filament unbundling within minutes. By demonstrating that actin filaments were more “organized” after a treatment that stopped elongation, we show there is no direct relationship between actin organization and cell expansion and refute the hypothesis that “more organized” actin universally correlates with more rapidly growing root cells. The plasma membrane-bound auxin transporter AUXIN RESISTANT 1 (AUX1) has previously been shown necessary for archetypal short-term root growth inhibition in the presence of IAA. Although AUX1 was not previously suspected of being upstream of cytoskeletal responses to IAA, we used aux1mutants to demonstrate that AUX1 is necessary for the full complement of actin rearrangements in response to auxin, and that cytoplasmic auxin in the form of the membrane permeable auxin 1‑naphthylacetic acid (NAA) is sufficient to stimulate a partial actin response. Together, these results are the first to quantitate actin cytoskeleton response to short-term auxin treatments and demonstrate that AUX1 is necessary for short-term actin remodeling.
Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
Creators: name: Füzik, Tibor
name: Formanová, Petra
name: Růžek, Daniel
name: Yoshii, Kentaro
name: Niedrig, Matthias
name: Plevka, Pavel
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin

description: Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. However, the structure of the TBEV virion and its interactions with antibodies are unknown. Here, we present cryo-EM structures of the native TBEV virion and its complex with Fab fragments of neutralizing antibody 19/1786. Flavivirus genome delivery depends on membrane fusion that is triggered at low pH. The virion structure indicates that the repulsive interactions of histidine side chains, which become protonated at low pH, may contribute to the disruption of heterotetramers of the TBEV envelope and membrane proteins and induce detachment of the envelope protein ectodomains from the virus membrane. The Fab fragments bind to 120 out of the 180 envelope glycoproteins of the TBEV virion. Unlike most of the previously studied flavivirus-neutralizing antibodies, the Fab fragments do not lock the E-proteins in the native-like arrangement, but interfere with the process of virus-induced membrane fusion.
Additional file 1 of Overexpression of Wnt5a promoted the protective effect of mesenchymal stem cells on Lipopolysaccharide-induced endothelial cell injury via activating PI3K/AKT signaling pathway
Creators: name: Guo, Manliang
name: Li, Shiqi
name: Li, Chuan
name: Mao, Xueyan
name: Tian, Liru
name: Yang, Xintong
name: Xu, Caixia
name: Zeng, Mian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 1.
HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors
Creators: name: Bannert, Norbert
name: Hofmann, Henning
name: Block, Adriana
name: Hohn, Oliver
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2018
Subjects: subject: HERV-K
subject: cancer
subject: human endogenous retrovirus (HERV)
subject: HERV
subject: innate sensing
subject: DNA-methylation
subject: viral mimicry
subject: 610 Medizin

description: Initial indications that retroviruses are connected to neoplastic transformation were seen more than a century ago. This concept has also been tested for endogenized retroviruses (ERVs) that are abundantly expressed in many transformed cells. In healthy cells, ERV expression is commonly prevented by DNA methylation and other epigenetic control mechanisms. ERVs are remnants of former exogenous forms that invaded the germ line of the host and have since been vertically transmitted. Several examples of ERV-induced genomic recombination events and dysregulation of cellular genes that contribute to tumor formation have been well documented. Moreover, evidence is accumulating that certain ERV proteins have oncogenic properties. In contrast to these implications for supporting cancer induction, a recent string of papers has described favorable outcomes of increasing human ERV (HERV) RNA and DNA abundance by treatment of cancer cells with methyltransferase inhibitors. Analogous to an infecting agent, the ERV-derived nucleic acids are sensed in the cytoplasm and activate innate immune responses that drive the tumor cell into apoptosis. This “viral mimicry” induced by epigenetic drugs might offer novel therapeutic approaches to help target cancer cells that are normally difficult to treat using standard chemotherapy. In this review, we discuss both the detrimental and the new beneficial role of HERV reactivation in terms of its implications for cancer.
sj-docx-1-ccp-10.1177_13591045211033186 – Supplemental Material for A survey of mental health professionals in a paediatric hospital during COVID-19
Creators: name: Ching, Brian CF
name: Bennett, Sophie D
name: Heyman, Isobel
name: Liang, Holan
name: Catanzano, Matteo
name: Fifield, Kate
name: Berger, Zoe
name: Gray, Suzanne
name: Hewson, Emma
name: Bryon, Mandy
name: Coughtrey, Anna E
name: Shafran, Roz
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental Material, sj-docx-1-ccp-10.1177_13591045211033186 for A survey of mental health professionals in a paediatric hospital during COVID-19 by Brian CF Ching, Sophie D Bennett, Isobel Heyman, Holan Liang, Matteo Catanzano, Kate Fifield, Zoe Berger, Suzanne Gray, Emma Hewson, Mandy Bryon, Anna E Coughtrey and Roz Shafran in Clinical Child Psychology and Psychiatry
sj-docx-1-rsh-10.1177_17579139211018243 – Supplemental material for Experiencing loneliness in parenthood: a scoping review
Creators: name: Nowland, R
name: Thomson, G
name: McNally, L
name: Smith, T
name: Whittaker, K
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-rsh-10.1177_17579139211018243 for Experiencing loneliness in parenthood: a scoping review by R Nowland, G Thomson, L McNally, T Smith and K Whittaker in Perspectives in Public Health
Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier
Creators: name: Dahm, Tobias
name: Adams, Ortwin
name: Boettcher, Sindy
name: Diedrich, Sabine
name: Morozov, Vasily
name: Hansman, Grant
name: Fallier-Becker, Petra
name: Schädler, Sebastian
name: Burkhardt, Claus J.
name: Weiss, Christel
name: Stump-Guthier, Carolin
name: Ishikawa, Hiroshi
name: Schroten, Horst
name: Schwerk, Christian
name: Tenenbaum, Tobias
name: Rudolph, Henriette
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2018
Subjects: subject: Meningitis
subject: CNS
subject: Enterovirus
subject: Echovirus (E-30)
subject: Blood-cerebrospinal fluid barrier
subject: Outbreak strains
subject: Tight junction
subject: Genomic sequencing
subject: Transcellular transmigration
subject: Paracellular transmigration
subject: 610 Medizin

description: Background: Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the blood-cerebrospinal fluid barrier (BCSFB), which has been demonstrated to be involved in enteroviral CNS pathogenesis, may affect the tight junction (TJ) and adherens junction (AJ) function and morphology. Methods: We used an in vitro human choroid plexus epithelial (HIBCPP) cell model to investigate the effect of three clinical outbreak strains (13-311, 13-759, and 14-397) isolated in Germany in 2013, and compared them to E-30 Bastianni. Conducting transepithelial electrical resistance (TEER), paracellular dextran flux measurement, quantitative real-time polymerase chain reaction (qPCR), western blot, and immunofluorescence analysis, we investigated TJ and AJ function and morphology as well as strain-specific E-30 infection patterns. Additionally, transmission electron and focused ion beam microscopy electron microscopy (FIB-SEM) was used to evaluate the mode of leukocyte transmigration. Genome sequencing and phylogenetic analyses were performed to discriminate potential genetic differences among the outbreak strains. Results: We observed a significant strain-dependent decrease in TEER with strains E-30 Bastianni and 13-311, whereas paracellular dextran flux was only affected by E-30 Bastianni. Despite strong similarities among the outbreak strains in replication characteristics and particle distribution, strain 13-311 was the only outbreak isolate revealing comparable disruptive effects on TJ (Zonula Occludens (ZO) 1 and occludin) and AJ (E-cadherin) morphology to E-30 Bastianni. Notwithstanding significant junctional alterations upon E-30 infection, we observed both para- and transcellular leukocyte migration across HIBCPP cells. Complete genome sequencing revealed differences between the strains analyzed, but no explicit correlation with the observed strain-dependent effects on HIBCPP cells was possible. Conclusion: The findings revealed distinct E-30 strain-specific effects on barrier integrity and junctional morphology. Despite E-30-induced barrier alterations leukocyte trafficking did not exclusively occur via the paracellular route.
Legislation of direct-to-consumer genetic testing in Europe: a fragmented regulatory landscape
Creators: name: Kalokairinou, L.
name: Howard, H. C.
name: Slokenberga, S.
name: Fisher, Eva
name: Flatscher-Thöni, M.
name: Hartlev, M.
name: Hellemondt, R. Van
name: Juškevičius, J.
name: Kapelenska-Pregowska, J.
name: Kováč, P.
name: Lovrečić, L.
name: Nys, Helene De
name: Paor, A. De
name: Phillips, A.
name: Prudil, L.
name: Rial-Sebbag, E.
name: Casabona, C. M. Romeo
name: Sándor, J.
name: Schuster, A.
name: Soini, S.
name: Søvig, K. H.
name: Stoffel, D.
name: Titma, T.
name: Trokanas, T.
name: Borry, P.
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: Direct-to-consumer genetic tests
subject: Regulation
subject: In vitro diagnostic medical devices
subject: Medical supervision
subject: Genetic counselling
subject: Informed consent
subject: 610 Medizin

description: Despite the increasing availability of direct-to-consumer (DTC) genetic testing, it is currently unclear how such services are regulated in Europe, due to the lack of EU or national legislation specifically addressing this issue. In this article, we provide an overview of laws that could potentially impact the regulation of DTC genetic testing in 26 European countries, namely Austria, Belgium, Cyprus, the Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, the Netherlands and the United Kingdom. Emphasis is placed on provisions relating to medical supervision, genetic counselling and informed consent. Our results indicate that currently there is a wide spectrum of laws regarding genetic testing in Europe. There are countries (e.g. France and Germany) which essentially ban DTC genetic testing, while in others (e.g. Luxembourg and Poland) DTC genetic testing may only be restricted by general laws, usually regarding health care services and patients’ rights.
Womxn and the 'Brilliant Jerks' They Work With: Sexism and Policy Knowledge Construction in the Technology Industry
Creators: name: Martinez, Emilly K
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Communication studies
Gender, sexuality and education
Organisational, interpersonal and intercultural communication

description: Despite heightened efforts to increase gender parity, organizations in the technology industry are struggling to implement and enact Gender Diversity and Inclusion policies (GDIPs). This purpose of this dissertation was to enhance understandings of obstacles to policy enactment and unearth ways in which organizations can create more equitable work environments. Specifically, this project investigated how members of technology organizations construct knowledge about Gender Diversity and Inclusion policies through their personal experiences, attitudes and beliefs, and interactions with others within and external to their organization. Utilizing a critical-interpretivist and intersectional feminism as ontological and epistemological frameworks, this dissertation study draws from structurating activity theory (SAT; Canary, 2010) and theories of organizational identification (Scott, 2007) to explore issues of policy knowledge construction, implementation, and enactment. Completed in two phases,this dissertation employed a mixed-methods design. Phase One used DeVellis’ (2017) framework to develop a Gender Diversity and Inclusion policy attitude scale (GDIPAS) to evaluate how personal opinions about GDIPs and larger constructs like sexism, feminism, identification, and social desirability contribute to the policy knowledge construction process. Phase Two used a parallel analysis design to quantitatively (i.e., surveys) and qualitatively (i.e., interviews) investigate how members of tech-based organizations construct GDIP knowledge through intra- and extra-organizational interactions, as well as personal beliefs and attitudes (Teddlie & Tashakkori, 2009). Phase One resulted in five-factors underlying Gender Diversity and Inclusion policy attitude: perception of policy abuse, policy familiarity, perception of workforce gender inequity, policy support, and perception of organizational gender diversity. Results from Phase Two indicated that members of technology organizations interact within and across activity systems to construct knowledge about GDIPs through structural contradictions that (re)produce barriers to policy implementation and enactment.This project contributed to organizational communication theory by investigating the role of organizational identification in the policy knowledge construction process. Further, this dissertation extended SAT by identifying two new structural contradictions and a primary system-level contradiction, and by centralizing power in the investigation of policy knowledge construction. Methodologically, this dissertation offers a new policy attitude measure for scholars and practitioners. Finally, results of this project provide practical insights into barriers to policy implementation and enactment.
Occurrence and distribution of Giardia species in wild rodents in Germany
Creators: name: Helmy, Yosra A.
name: Spierling, Nastasja G.
name: Schmidt, Sabrina
name: Rosenfeld, Ulrike M.
name: Reil, Daniela
name: Imholt, Christian
name: Jacob, Jens
name: Ulrich, Rainer G.
name: Aebischer, Toni
name: Klotz, Christian
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2018
Subjects: subject: Giardia spp.
subject: Protozoan infection
subject: Sequence typing
subject: Wild rodents
subject: Reservoir
subject: 610 Medizin

description: Background: Giardiasis is an important gastrointestinal parasitic disease in humans and other mammals caused by the protozoan Giardia duodenalis. This species complex is represented by genetically distinct groups (assemblages A-H) with varying zoonotic potential and host preferences. Wild rodents can harbor potentially zoonotic assemblages A and B, and the rodent-specific assemblage G. Other Giardia spp. found in these animals are Giardia muris and Giardia microti. For the latter, only limited information on genetic typing is available. It has been speculated that wild rodents might represent an important reservoir for parasites causing human giardiasis. The aim of this study was to investigate the occurrence and distribution of Giardia spp. and assemblage types in wild rodents from different study sites in Germany. Results: Screening of 577 wild rodents of the genera Apodemus, Microtus and Myodes, sampled at eleven study sites in Germany, revealed a high overall Giardia prevalence. Giardia species determination at the SSU rDNA gene locus revealed that Apodemus mice, depending on species, were predominantly infected with one of two distinct G. muris sequence types. Giardia microti was the predominant parasite species found in voles of the genera Microtus and Myodes. Only a few animals were positive for potentially zoonotic G. duodenalis. Subtyping at the beta-giardin (bg) and glutamine dehydrogenase (gdh) genes strongly supported the existence of different phylogenetic subgroups of G. microti that are preferentially harbored by distinct host species. Conclusions: The present study highlights the preference of G. muris for Apodemus, and G. microti for Microtus and Myodes hosts and argues for a very low prevalence of zoonotic G. duodenalis assemblages in wild rodents in Germany. It also provides evidence that G. muris and G. microti subdivide into several phylogenetically distinguishable subgroups, each of which appears to be preferentially harbored by species of a particular rodent host genus. Finally, the study expands the database of sequences relevant for sequence typing of G. muris and G. microti isolates which will greatly help future analyses of these parasites’ population structure.
Additional file 1 of A cluster-randomized study to evaluate the effectiveness and cost-effectiveness of the Assessment of Burden of Chronic Conditions (ABCC) tool in South Tyrolean primary care for patients with COPD, asthma, type 2 diabetes, and heart failure: the ABCC South Tyrol study
Creators: name: Wiedermann, Christian J.
name: Marino, Pasqualina
name: Mahlknecht, Angelika
name: Barbieri, Verena
name: Piccoliori, Giuliano
name: Engl, Adolf
name: Gidding-Slok, Annerika H. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy

description: Additional file 1: Supplementary material.
Effect of Storage Humidity on Physical Stability and Aerosol Performance of Spray-Dried Dry Powder Inhaler Formulations
Creators: name: Shetty, Nivedita J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Pharmaceutical sciences

description: Dry Powder inhalers (DPIs) have been one of the most promising developments in pulmonary drug delivery systems. In general, DPIs are more effective than systemic administrations and convenient to use. However, delivering high-dose antibiotics through a DPI is still a challenge because high powder load may need a very large inhaler or increase the incidence of local adverse effects. Spray drying has been increasingly applied to produce DPI formulations for high-dose antibiotics; nevertheless, many spray-dried particles are amorphous and physically unstable during storage, particularly under the humid environment. My research focuses on addressing critical challenges in physical stability of DPIs for spray-dried high-dose antibiotics. The effects of moisture-induced crystallization on physical stability and aerosol performance of spray-dried amorphous Ciprofloxacin DPI formulations stored at different humidity conditions were studied. Our study not only provided a mechanistic understanding in the impact of crystallization on aerosol performance but also developed novel approaches for improving stability of spray-dried formulations used in DPI. Our work has shown that recrystallization of amorphous spray-dried Ciprofloxacin led to significant changes in aerosol performance of DPIs upon storage, which cause critical quality and safety concerns. These challenges have been solved through co-spray-drying Ciprofloxacin with either excipient such as leucine or synergistic antibiotic like Colistin. Co-spray-drying Ciprofloxacin with Colistin not only improved physical and aerosol stability but also enhanced antibacterial activity which is a great advantage for treating ‘difficult to cure’ respiratory infections caused by multidrug resistant bacteria. My research work is a sincere effort to maximize the utility and efficacy of high-dose DPI, an effective delivery tool for treating severe resistant bacterial respiratory infections.
FSME: Risikogebiete in Deutschland (Stand: April 2018)
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2018
Subjects: subject: FSME
subject: Erkrankungsrisiko
subject: 610 Medizin

description: In Deutschland besteht weiterhin ein Risiko für eine FSME-Infektion vor allem in Bayern und Baden-Württemberg, in Südhessen und im südöstlichen Thüringen. Einzelne Risikogebiete befinden sich zudem in Mittelhessen (LK Marburg- Biedenkopf), im Saarland (LK Saar-Pfalz-Kreis) und in Rheinland-Pfalz (LK Birkenfeld). Im Jahr 2014 wurde der Landkreis (LK) Vogtlandkreis als erster sächsischer Kreis zum FSME-Risikogebiet erklärt. Nun kommen in Sachsen 3 weitere Risikogebiete hinzu, und zwar die LK Erzgebirgskreis, Bautzen und Zwickau, die alle an bekannte Risikogebiete in Deutschland oder Tschechien grenzen. Zudem werden in Thüringen der LK Ilm-Kreis und der Stadtkreis (SK) Suhl und in Bayern die 5 Kreise LK München, LK Günzburg, LK Augsburg, LK Weilheim- Schongau und der LK Starnberg als Risikogebiete definiert. Somit sind aktuell 156 Kreise als FSME-Risikogebiete definiert. Nachdem in den Vorjahren meist nur zwischen 0 – 3 neue Risikogebiete hinzukamen, kommt die große Anzahl von aktuell 10 neuen Risikogebieten durch die hohe FSME-Inzidenz im Jahr 2017 zustande. Alle neuen Risikogebiete grenzen an bestehende Risikogebiete in Deutschland oder Tschechien. Es wurden jedoch auch in Bundesländern ohne FSME-Risikogebiete vereinzelt FSME-Erkrankungen beobachtet, sodass besonders während der Zeckensaison bei entsprechender Symptomatik überall in Deutschland differenzialdiagnostisch an FSME gedacht werden sollte. Die STIKO empfiehlt eine FSME-Impfung für Personen, die in FSME-Risikogebieten zeckenexponiert sind. Nach einem Anstieg der Impfquoten in diesen Gebieten bis ca. 2009/2010 stagnierten sie in den letzten Jahren oder nahmen sogar ab. Die Mehrzahl (97 %) der 2017 gemeldeten FSME-Erkrankten war gar nicht oder unzureichend geimpft. Ein hoher Anteil der auftretenden FSMEErkrankungen könnte also durch eine Steigerung der Impfquoten insbesondere in Risikogebieten mit hoher FSME-Inzidenz verhindert werden.
HOMEWORK IS ASSOCIATED WITH ANXIETY IN STUDENTS
Creators: name: Annous, Ibtissam
Publisher: name: Maryland Shared Open Access Repository
Year: 2017
Subjects: subject: Homework and anxiety
subject: Education -- Research papers (Graduate).

description: The purpose of this descriptive study was to determine if homework is associated with anxiety in students. A survey was delivered to medical professionals in a hospital setting in Washington, DC. Only twenty respondents completed the questions. The amount of time the participants were last enrolled in school varied from less than four years, four to six years, seven to ten years and eleven or more years. The results of this study were supported by the majority of respondents who experienced different levels of anxiety while doing homework.
Cooled Turbine Tip Design: Aerothermal Optimization for Engine Transients
Creators: name: Andreoli, Valeria
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Mechanical engineering not elsewhere classified

description: This thesis presents optimal cooled turbine tip designs that demonstrate a superior performance during an entire engine transient. The improvement of efficiency is obtained by optimizing the shape of the cooled turbine tip, considering all the phenomena associated with clearance variations. Optimal turbine blade tip designs not only enhance the aerodynamic performance, but they also reduce the thermal loads on one of the most vulnerable parts of the gas turbine. A multi-objective optimization was performed using a differential evolution strategy and Computational Fluid Dynamics software to solve Reynolds-Averaged Navier-Stokes equations. The results showed the strong impact of the over-tip coolant flows on the over-tip flow field. A detailed model for the scaling of tip convective heat flux based on Green’s functions was developed to predict the overtip heat flux at various gaps and engine conditions. The turbine aerothermal models integrated with the mathematical model of the entire engine were used to assess the effect of an improved turbine design on the overall gas turbine performance. Finally, this thesis proposes an experimental approach to validate the numerical models of the turbine aerothermal performance. This experimental procedure relies on an extensive computational analysis which resulted in the development of an unprecedented facility. This new facility, built at Purdue University, will be extensively used to evaluate transients with ad-hoc instrumentation designed using CFD. This work proposes a methodology to extrapolate the experimental results to engine conditions, in terms of aerothermal performance focusing on tip flow.
Sensitivity Analysis and Topology Optimization in Plasmonics
Creators: name: Zeng, Zhou
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified
Numerical and computational mathematics not elsewhere classified
Optimisation
Electrical engineering not elsewhere classified

description: The rapid development of topology optimization in photonics has greatly expanded the number of photonic structures with extraordinary performance. The optimization is usually solved by using a gradient-based optimization algorithm, where gradients are evaluated by the adjoint sensitivity analysis. While the adjoint sensitivity analysis has been demonstrated to provide reliable gradients for designs of dielectrics, there has not been too much success in plasmonics. The difficulty of obtaining accurate field solutions near sharp edges and corners in plasmonic structures, and the strong field enhancement jointly increase the numerical error of gradients, leading to failure of convergence for any gradient-based algorithm. We present a new method of calculating accurate sensitivity with the FDTD method by direct differentiation of the time-marching system in frequency domain. This new method supports general frequency-domain objective functions, does not relay on implementation details of the FDTD method, works with general isotropic materials and can be easily incorporated into both level-set-based and density-based topology optimizations. The method is demonstrated to have superior accuracy compared to the traditional continuous sensitivity. Next, we present a framework to carry out density-based topology optimization using our new sensitivity formula. We use the non-linear material interpolation to counter the rough landscape of plasmonics, adopt the filteringand-projection regularization to ensure manufacturability and perform the optimization with a continuation scheme to improve convergence. We give two examples involving reconstruction of near fields of plasmonic structures to illustrate the robustness of the sensitivity formula and the optimization framework. In the end, we apply our method to generate a rectangular temperature profile in the recording medium of the HAMR system.
TAQDIMOT SLAYDLARINI YARATISH BOʻLIMINI OʻQITISH METODIKASI
Creators: name: Uzoqova, Shoira
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: "Taqdimot slaydlarini yaratish boʻlimini oʻqitish metodikasi" bu taqdimot slaydlarini samarali yaratish va ularni ta'lim jarayonida qanday foydalanishni o'rgatish bo'yicha metodik yondoshuvlarni taqdim etadi. Maqolada taqdimot slaydlarining o'quvchilarga ta'lim berishda qanday ahamiyatga ega ekanligi, ularning diqqatini jalb qilish va axborotni samarali yetkazishdagi roli tahlil qilingan. Slaydlarni yaratishning asosiy prinsiplariga, vizual va matnli elementlarning muvofiqligiga, shuningdek, slaydlarning strukturaviy tuzilishiga alohida e'tibor qaratilgan. Ushbu metodika taqdimot slaydlarini yaratishda o'qituvchilarga kerakli ko'nikmalarni berish, ta'lim jarayonini yaxshilash va o'quvchilarning o'zlashtirish darajasini oshirishga qaratilgan. Maqola shuningdek, taqdimotlarni o'qitishda zamonaviy texnologiyalar va interaktiv usullarni qanday qo'llash mumkinligi haqida tavsiyalar beradi.
sj-pdf-1-tdo-10.1177_00494755211032095 - Supplemental material for Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients
Creators: name: Panda, Prateek Kumar
name: Sharawat, Indar Kumar
name: Panda, Pragnya
name: Dawman, Lesa
name: Kasinathan, Ananthanarayanan
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-tdo-10.1177_00494755211032095 for Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients by Prateek Kumar Panda, Indar Kumar Sharawat, Pragnya Panda, Lesa Dawman and Ananthanarayanan Kasinathan in Tropical Doctor
Does a Meat tax Trump Green Label Education Effects
Creators: name: Lawing, Jonthan Webster
Publisher: name: Purdue University Graduate School
Year: 2019

description: External cost from meat consumption raises an issue of possible government mechanisms toward mitigation. Economic theory provides a framework for determining the optimal set of mechanisms considering the associated benefits and costs. Such a theoretical development rests on the responsiveness of consumers to alternative mechanisms. Considering two mechanisms, a Pigouvian tax and green-label education, yields tandem theoretical optimal government mechanisms. Populating this theoretical model with empirically derived elasticities and other parameters provides an application. Results indicate education alone will likely not yield a high social-optimal level of mitigation. Instead, a Pigouvian tax will be required to move consumption toward a socially desired state.
Additional file 7 of Identification of QTL for kernel weight and size and analysis of the pentatricopeptide repeat (PPR) gene family in cultivated peanut (Arachis hypogaea L.)
Creators: name: Fang, Yuanjin
name: Liu, Hua
name: Qin, Li
name: Qi, Feiyan
name: Sun, Ziqi
name: Wu, Jihua
name: Dong, Wenzhao
name: Huang, Bingyan
name: Zhang, Xinyou
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7: Fig S6. Distribution of the Pentatricopeptide Repeat (PPR) gene family in the Arachis hypogaea cv Tifrunner genome.