cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nativity differences in allostatic load by age, sex, and Hispanic background from the Hispanic Community Health Study/Study of Latinos
Creators: name: Isasi, Carmen R.
name: Lipton, Richard B.
name: Seeman, Teresa E.
name: Arguelles, William
name: Salazar, Christian R.
name: Sanders, Anne E.
name: Avilés-Santa, Larissa M.
name: Cai, Jianwen
name: Kaplan, Robert C.
name: Penedo, Frank J.
name: Strizich, Garrett
name: Gallo, Linda C.
Publisher: name: Elsevier
Year: 2016

description: Allostatic load (AL), an index of biological "wear and tear" on the body from cumulative exposure to stress, has been little studied in US Hispanics/Latinos. We investigated AL accumulation patterns by age, sex, and nativity in the Hispanic Community Health Study/Study of Latinos. We studied 15,830 Hispanic/Latinos of Mexican, Cuban, Dominican, Puerto Rican, Central and South American descent aged 18-74 years, 77% of whom were foreign-born. Consistent with the conceptualization of AL, we developed an index based upon 16 physiological markers that spanned the cardiometabolic, parasympathetic, and inflammatory systems. We computed mean adjusted AL scores using log-linear models across age-groups (18-44, 45-54, 55-74 years), by sex and nativity status. Among foreign-born individuals, differences in AL by duration of residence in the US (<10, ≥10 years) and age at migration (<24, ≥24 years) were also examined. In persons younger than 55 years old, after controlling for socioeconomic and behavioral factors, AL was highest among US-born individuals, intermediate in foreign-born Hispanics/Latinos with longer duration in the US (≥10 years), and lowest among those with shorter duration in the US (<10 years) (P <0.0001 for increasing trend). Similarly, AL increased among the foreign-born with earlier age at immigration. These trends were less pronounced among individuals ≥55 years of age. Similar patterns were observed across all Hispanic/Latino heritage groups (P for interaction=0.5). Our findings support both a "healthy immigrant" pattern and a loss of health advantage over time among US Hispanics/Latinos of diverse heritages.
Supplementary document for Correcting for Spatial-Spectral Crosstalk and Chromatic Aberrations in Broadband Line-Scan Spectral-Domain OCT images - 6320287.pdf
Creators: name: HAN, LE
name: Bizheva, Kostadinka
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary file
BRAF testing in metastatic colorectal carcinoma and novel, chemotherapy-free therapeutic options
Creators: name: Hummel, Michael
name: Hegewisch-Becker, Susanna
name: Neumann, Jens H. L.
name: Vogel, Arndt
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Cetuximab
subject: Encorafenib
subject: BRAF-inhibitors
subject: Protein kinase inhibitors
subject: Proto-oncogene proteins B-raf
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In the past 25 years, treatment of metastatic colorectal cancer (mCRC) has undergone profound changes. The approval of newer chemotherapeutics such as irinotecan and oxaliplatin was followed in 2005 by the first targeted therapies, for example, monoclonal antibodies directed against the epidermal growth factor receptor (EGFR), as cetuximab and panitumumab, or the angiogenesis inhibitors bevacizumab, ramucirumab, and aflibercept. With the rapidly progressing molecular characterization of mCRC in the last 10 years and the classification of the disease in four consensus subtypes, further changes are emerging, which will promote, among other things, the introduction of protein-kinase inhibitors developed for specific molecular aberrations as well as immune checkpoint inhibitors into the treatment algorithm. Thorough molecular pathologic testing is indispensable today for guideline-compliant treatment of mCRC patients. In addition to RAS testing as a precondition for the therapy decision with regard to cetuximab and panitumumab, BRAF testing is of considerable relevance to allow decision making with regard to the newly approved chemotherapy-free combination of the BRAF inhibitor encorafenib and cetuximab in cases where a BRAF-V600E mutation is detected. Additional diagnostic tests should also include genome instability (microsatellite instability). Overall, more and more molecular alterations need to be investigated simultaneously, so that the use of focused next-generation sequencing is increasingly recommended. This overview describes the prognostic relevance of BRAF testing in the context of molecular pathologic diagnostics of mCRC, presents new treatment options for BRAF-mutated mCRC patients, and explains which modern DNA analytical and immunohistochemical methods are available to detect BRAF mutations in mCRC patients.
ХУДОЖЕСТВЕННАЯ ОСОБЕННОСТЬ ПРОИЗВЕДЕНИЙ РУССКОЙ И УЗБЕКСКОЙ ЛИТЕРАТУРЫ ХХ ВЕКА НА СТЫКЕ КУЛЬТУР
Creators: name: Амонова, Гулрухсор
name: Имомкулова, Муслима
Publisher: name: Zenodo
Year: 2025

description: в статье рассматривается взаимовлияние двух культур (русской и узбекской) на художественные особенности произведений поэтов и писателей ХХ века. Описаны некоторые факторы культурного воздействия, внешне отображающиеся на литературе исследуемого периода. А также выялены и представлены примеры из художественных произведений.
Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial
Creators: name: Gomez-Mancilla, Baltazar
name: Feuerbach, Dominik
name: Marder, Stephen R.
name: Buchanan, Robert W.
name: Weiss, Markus
name: Cronenwett, Will
name: Maguire, Ralph P.
name: Pezous, Nicole
name: Barch, Deanna M.
name: Behrje, Rhett B.
name: Lopez-Lopez, Cristina
name: Jarskog, L. Fredrik
name: Johns, Donald R.
name: Chen, Li-Shiun
name: Harms, Michael P.
Publisher: name: Elsevier
Year: 2016

description: INTRODUCTION: AQW051, an α7-nicotinic acetylcholine receptor partial agonist, enhanced cognitive function in rodent models of learning and memory. This study evaluated brain activation during performance of a working memory task (WMT) and an episodic memory task (EMT), and the effect of AQW051 on task-related brain activation and performance in subjects with schizophrenia.
METHODS: This was a double-blind, randomized, placebo-controlled, multicenter, 2-period cross-over trial (NCT00825539) in participants with chronic, stable schizophrenia. Participants, stratified according to smoking status, were randomized (1:1:1:1:1:1) to 1 of 6 sequence groups that determined the study drug dose (AQW051 7.5mg, 50mg or 100mg) and order of administration versus placebo. The primary outcome was brain activation in a priori target regions of interest (ROIs) during performance of the WMT and EMT, measured using functional magnetic resonance imaging. The effect of AQW051 on task-related (EMT and WMT) brain activation and performance was also assessed, as were safety and tolerability.
RESULTS: Overall, 60 of 68 enrolled participants completed the study (AQW051 then placebo: 7.5mg n=9; 50mg n=11; 100mg n=10. Placebo then AQW051: 7.5mg n=10; 50mg n=11; 100mg n=9). Significant task-related brain activation (5% significance level) was observed with placebo. During the WMT, a medium effect size was observed in the inferior prefrontal cortex with AQW051 100mg versus placebo (0.431; p=0.105). During the EMT encoding phase, a large effect size was observed in the anterior hippocampus (0.795; p=0.007) and a medium effect size in the posterior hippocampus (0.476; p=0.079) with AQW051 7.5mg. No other medium/large effect sizes were observed with any dose on either task. Effects on brain activation were generally not associated with changes in cognitive performance. AQW051 was well tolerated with an acceptable safety profile.
CONCLUSIONS: Overall, no consistent effects of AQW051 on brain regions involved in the performance of a WMT or EMT were observed; however, this study presents a model for evaluating potential response to pharmacological interventions for cognitive impairment in schizophrenia.
title: Hamlet in American Interpretations
Creators: name: Engberg, Harald
Publisher: name: George Mason University
Year: 1997
Subjects: subject: Hamlet
subject: Engberg, Harald
subject: Breen, Robert
subject: Derwent, Clarence
subject: Davis, Blevins
subject: Boyle, Ray
subject: Borgnine, Ernest
subject: Lynn-Thomas, Derrick
subject: Abel, Walter
subject: Ford, Ophelia
subject: MacMahon, Aline

description: Theater review.
title: Mastering Scrum
title: exploring practical challenges and deriving a novel software solution
titleType: Subtitle
Creators: name: Hülsmann, Adrian
Publisher: name: Universität Paderborn
Year: 2025

description: Mehr als 75 % aller Softwareprojekte werden heutzutage mit agilen Methoden durchgeführt. Dabei wird in 80 % der Fälle Scrum eingesetzt, welches das weltweit beliebteste Softwareentwicklungsframework darstellt. Durch den einfachen Aufbau und das klare Regelwerk gilt das Scrum-Framework als leicht verständlich. Allerdings zeigen sich in der praktischen Umsetzung immer wieder Probleme, die dazu führen, dass nicht das gesamte Potential der Methodik genutzt wird, wodurch sich Projektlaufzeiten verlängern und damit die Kosten zur Entwicklung von Software erhöhen können.Diesem Problem widmet sich diese Arbeit. Sie konzentriert sich dabei auf die Analyse heutiger Projektmanagementanwendungen und stellt fest, dass diese nicht in der Lage sind, die Probleme bei der Umsetzung von Scrum adäquat zu adressieren. Aus diesem Grund wird eine neue Softwarelösung vorgestellt, die das agile Entwicklungsframework zur Gänze abbildet und Scrum-Teams bei der Bewältigung der praktischen Implementierungsprobleme besser unterstützt.
description: More than 75% of current software projects utilize agile development methods, with Scrum being employed in 80% of these projects, making it the most popular software development framework. Despite its straightforward structure and simple rules, practical implementation issues often hinder the methodology from achieving its full potential, resulting in prolonged project durations and increased development costs. This thesis is dedicated to this problem. Focusing on analyzing current Scrum project management solutions and identifying their failure to adequately address the issues with Scrum, it proposes a new software solution that fully maps the agile development framework and better supports Scrum teams in overcoming practical implementation problems.
Studienprotokoll: Register zur Prognose akut-symptomatischer Anfälle (PROSA-Register) – eine prospektive multizentrische Beobachtungsstudie
Creators: name: Herzig-Nichtweiß, Julia
name: Salih, Farid
name: Berning, Sascha
name: Malter, Michael
name: Pelz, Johann
name: Lochner, Piergiorgio
name: Wittstock, Matthias
name: Günther, Albrecht
name: Alonso, Angelika
name: Fuhrer, Hannah
name: Schönenberger, Silvia
name: Petersen, Martina
name: Kohle, Felix
name: Müller, Annekatrin
name: Gawlitza, Alexander
name: Gubarev, Waldemar
name: Holtkamp, Martin
name: Vorderwülbecke, Bernd
name: Das IGNITE!-Forschungsnetzwerk Der Deutschen Gesellschaft Für Neurointensiv- Und -Notfallmedizin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Epileptic seizure
subject: Early seizure
subject: Structural etiology
subject: Observational study
subject: Seizure outcome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Acute symptomatic epileptic seizures occur in close temporal relation to an acute disturbance of brain function. They are associated with a low risk of subsequent unprovoked seizures; thus, current guidelines recommend not to administer a long-term antiseizure medication; however, in clinical practice long-term secondary seizure prophylaxis is frequently initiated. The seizure prognosis after guideline-conform untreated or only briefly treated acute symptomatic seizures, is so far unknown. Hypothesis: Following an acute symptomatic first epileptic seizure of structural etiology, the 1-year risk of subsequent unprovoked seizures is not higher than 25%, even if antiseizure medication was not applied or for a short period only. Methods: The PROSE register is a single-arm, open, prospective, multicenter observational study. A total of 115 subjects aged 18 years or older with an acute symptomatic first epileptic seizure of structural etiology will be included if the seizure was not a status epilepticus. Intrahospital follow-up will be based on the hospital records. Telephone follow-up interviews will be conducted 3, 6, and 12 months after the acute symptomatic seizure. Discussion: The PROSE register will shed light on current treatment practice of acute symptomatic seizures and the actual seizure outcome within 1 year. The results are assumed to support the current evidence that giving antiseizure medication for a longer period of time exceeding the acute phase of the underlying condition is unnecessary.
Supplementary document for Mechanism and tuning sensitivity of symmetry-protected resonances in high-contrast gratings - 6320344.pdf
Creators: name: Yao, Hsin-Yu
name: Wang, Yi-Chen
name: Hadavandmirzaee, Fatemeh
name: Chang, Tsun-Hsu
name: Her, Tsing-Hua
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma
Creators: name: Thomas, R.
name: Demeter, Z.
name: Borst, L.
name: Kennedy, K. A.
name: Le Boedec, K.
name: Singh, K.
name: Breen, M.
name: Valli, V. E.
Publisher: name: Wiley
Year: 2016

description: Follicular lymphomas (FLs) typically exhibit a chromosome translocation that induces constitutive expression of the anti-apoptotic bcl2 protein and accumulation of additional molecular defects. This rearrangement offers a promising therapeutic target, but its nature as a fundamental driver of FL pathogenesis remains unclear as 15% of cases lack the translocation. We performed an integrated immunohistochemical and genomic investigation of 10 naturally occurring FL cases from domestic dogs, showing that, as with human tumours, they exhibit marked heterogeneity in the frequency and intensity of bcl2 protein expression. Genomic copy number aberrations were infrequent and broadly consistent with those of other canine B-cell lymphoma subtypes. None of the canine FL specimens exhibited a rearrangement consistent with the hallmark translocation of human FL, despite their remarkable histomorphologic similarity. Parallel exploration of canine and human cases may reveal alternative tumour-initiating mechanisms other than BCL2 disruption, yielding a more complete definition of the molecular pathogenesis of FL.
title: Envelope: Embossed Mason Patriots Envelope with Cancellation Stamp, April 7, 2006
Creators: name: United States Postal Service
Publisher: name: George Mason University
Year: 2006
Subjects: subject: George Mason University
subject: Basketball
subject: Fairfax City (VA)
subject: Cancellation stamp
subject: Envelope

description: Envelope: color, 4.25" x 9" (10.8 cm x 22.9 cm)
description: Limited-edition color embossed envelope bearing a cancellation stamp of the Mason Patriots logo. The envelope, stamped at Fairfax Station, VA on April 7, 2006 was part of the citywide celebration for the Patriots' tournament run. 2005-06 Men's Basketball Season and Tournament Run Collection 2.05
title: Kinsey Dialogue Series #3 Landscaping the Learning Environment to Create a Home for the Complex Mind
Creators: name: Visser, Jan
Publisher: name: University of Massachusetts Amherst
Year: 2001
Subjects: subject: Bilingual, Multilingual, and Multicultural Education
subject: Curriculum and Instruction
subject: Curriculum and Social Inquiry
subject: Educational Assessment, Evaluation, and Research
subject: Educational Methods

description: The Kinsey Dialogue Series was established in memory of our beloved colleague, David Chapin Kinsey. David Touched Countless lives in the course of his 40 years as a dedicated, brilliant and outstanding educator, helping people everywhere to inquire, explore and discover the world and themselves. From 1975, David Kinsey served as a faculty member of the School of Education in the Center for International Education at the University of Massachusetts at Amherst. It is our hope that the Kinsey Dialogue Series will uphold his legacy, keeping alive his passionate vision for a better world.
description: I am going to use the opportunity presented by the 2001 David Kinsey lecture to bring together some ideas expressed in m recent work and to reflect on my decades-long experience in creating the conditions for the development of learning in an international context. That experience, and my reflections on it, has led me to recognize that learning is an immensely more complex phenomenon than most of our current practice to promote and facilitate it would have us believe. Consequently, I have come to the conclusion that the complex human mind is poorly at home in much of the environment supposedly created to nurture it. Neglect of the essential conditions for its sustenance and growth has led the mind to lose its natural habitat, putting it at risk of becoming extinct. My emphasis will therefore be on what should be done to landscape the learning environment in such a way that the complex mind can find a home in it. I shall develop my ideas and raise questions about this issue, while calling attention to a number of key concepts.
title: The Study of Retinal Organoids: Development, Modeling, and Transplantation
Creators: name: Farag, Sally
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Retinal Organoids
subject: Retinal Modeling

description: There are several different retinal diseases prominent within the United States including age-related macular degeneration (AMD), diabetic retinopathy, and glaucoma. These three particular retinal diseases affect a total of 12.5 million people in the US alone, showing that retinal diseases are a very prevalent issue that require an improvement in the methodology of treatment. Retinal diseases can cause blindness and drastically decrease quality of life. To better treat these diseases and provide patients with proper care, it is important to maintain a proper understanding of the retina. It has been found that retinal organoids (ROs) can be produced through the use of stem cells. When perfected, these ROs can provide advanced modeling of the retina, as well as modeling of novel treatments for retinal diseases and allow for better testing. Additionally, ROs can be modified in order to better depict retinal diseases and their microenvironments. They may also be used for retinal transplants as a method of treatment. However, ROs are still being developed and understood. Before the full use and benefits of ROs can be reaped, the differences between ROs and natural retinas must be understood and minimized. Additionally, various issues within the ROs themself must be tackled in order for their uses to become more advanced.
Stellenwert von Mycophenolat-Mofetil zur Behandlung der interstitiellen Lungenerkrankung bei systemischer Sklerose
Creators: name: Schneider, Udo
name: Siegert, Elise
name: Gläser, Sven
name: Krüger, Klaus
name: Krause, Andreas
name: Die Kommission Pharmakotherapie Der DGRh
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Immunosuppression
subject: Cyclophosphamide
subject: Tocilizumab
subject: Nintedanib
subject: SSc-ILD
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Interstitial lung disease in systemic sclerosis (SSc-ILD) is a frequent organ complication with considerable mortality. Therapeutically, immunosuppressants are primarily used, particularly cyclophosphamide (CYC) and mycophenolate mofetil (MMF). Recently acquired data also showed an efficacy of the biologics rituximab and tocilizumab. The therapeutic options have most recently been expanded by the approval of the antifibrotic drug nintedanib. It is particularly beneficial in progressive fibrosing courses of ILD despite immunosuppression. The data from controlled trials on the efficacy and safety of CYC and MMF compiled in this review argue for a preferential use of MMF; however, the approval of MMF for this indication is still lacking. This is urgently needed for improved and simplified care of patients with SSc-ILD.
title: Letter: C. Harrison Mann, Jr. to Harry F. Byrd, October 28, 1961
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Kerr-Mills Act
subject: Student loans
subject: Social Security

description: Letter: typescript unsigned, 8.5" x 11" (21.6 cm x 27.9)
description: Letter from C. Harrison Mann, Jr. to Harry F. Byrd, senator from Virginia, regarding Byrd's opposition to Social Security, asking for the endorsement of the Kerr-Mills Act, and comments on expanding the federal student loan program. C. Harrison Mann Collection 3.10
Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach
Creators: name: Howe, George
name: Montag, Samantha
name: Pantin, Hilda
name: Cruden, Gracelyn
name: Brincks, Ahnalee
name: Huang, Shi
name: Young, Jami F.
name: Sandler, Irwin
name: Brown, C. Hendricks
name: Perrino, Tatiana
name: Beardslee, William
Publisher: name: Springer Nature
Year: 2016

description: This paper presents the first findings of an integrative data analysis of individual-level data from 19 adolescent depression prevention trials (n = 5210) involving nine distinct interventions across 2 years post-randomization. In separate papers, several interventions have been found to decrease the risk of depressive disorders or elevated depressive/internalizing symptoms among youth. One type of intervention specifically targets youth without a depressive disorder who are at risk due to elevated depressive symptoms and/or having a parent with a depressive disorder. A second type of intervention targets two broad domains: prevention of problem behaviors, which we define as drug use/abuse, sexual risk behaviors, conduct disorder, or other externalizing problems, and general mental health. Most of these latter interventions improve parenting or family factors. We examined the shared and unique effects of these interventions by level of baseline youth depressive symptoms, sociodemographic characteristics of the youth (age, sex, parent education, and family income), type of intervention, and mode of intervention delivery to the youth, parent(s), or both. We harmonized eight different measures of depression utilized across these trials and used growth models to evaluate intervention impact over 2 years. We found a significant overall effect of these interventions on reducing depressive symptoms over 2 years and a stronger impact among those interventions that targeted depression specifically rather than problem behaviors or general mental health, especially when baseline symptoms were high. Implications for improving population-level impact are discussed.
Supplementary document for Photon-limited Cherenkov imaging of radiation therapy dose - 6320521.pdf
Creators: name: Jia, Mengyu
name: SUN, BOSHUAI
name: WANG, YUXIA
name: Gao, Feng
name: yuan, zhiyong
name: Pogue, Brian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplement
Pre-cycling contemplation–an explanation on the interplay between recycling consideration and purchase intention, and the role of semiotic knowledge
Creators: name: Nguyen, Dung
name: D'Souza, Clare
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3507
subject: Strategy, management and organisational behaviour
classificationCode: 35
subject: Commerce, management, tourism and services
classificationCode: 3503
subject: Business systems in context
classificationCode: 3506
subject: Marketing
subject: FOS: Economics and business

description: The waste crisis in Australia has been exacerbated in recent years, emphasising the need to investigate consumer recycling. Purchasing intention of products with recyclable packaging, or recycling shopping behaviour, is identified as a more relevant touchpoint to improve overall recycling efforts, indicating that recycling signs and relevant constructs are important to be investigated. Drawing the conceptual framework from the Theory of Planned Behaviour and extending it, the study aimed at investigating the influences of semiotic knowledge, or the knowledge of signs, on recycling shopping behaviour in the context of Fast-Moving Consumers’ Goods. The construct of precycling was also conceptualised and incorporated in the model to establish the prerequisite conditions for semiotic knowledge. Using Structural Equation Modelling and AMOS 26 software, the research validated moral norms and recycling considerations as the factors constituting one’s pre-cycling contemplation, with semiotic knowledge displaying a moderating effect. The research contributes to the domain of recycling shopping behaviour and precycling, in which semiotic knowledge is found to enhance consumers’ tendency for purchasing products with recyclable packaging. Recommendations were made towards manufacturers in retail environments and policymakers for waste reduction.
title: The American National Theatre
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 1995
Subjects: subject: Breen-Porterfield Plan
subject: ANTA
subject: USO Camp Shows, Inc.
subject: National Theatre Foundation
subject: Breen, Robert
subject: Porterfield, Robert
subject: Lord Keynes
subject: Thomas, Elbert
subject: Stokowski, Leopold
subject: Hutchinson, Amory
subject: French, Mary Stewart
subject: Mason, Clara
subject: Reber, J. Howard
subject: Freedley, Vinton
subject: Kahn, Otto
subject: Campbell, C. Lawton
subject: Sherwood, Robert E.
subject: Miller, Gilbert
subject: see pages 6 and 7

description: Brochure.
title: Letter: C. Harrison Mann, Jr. to John F. Dulles, May 13, 1954
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2005
Subjects: subject: Dulles, John Foster, 1888-1959
subject: Vietnam

description: Letter: typescript unsigned, 11" x 8.5" (29.7 cm x 21.6 cm)
description: Letter from C. Harrison Mann, Jr. to John F. Dulles, Secretary of State, regarding if the United States should become involved in the situation in Vietnam , then known as Indo-China. C. Harrison Mann, Jr. Collection 3.01
Conception and evaluation of a washable multimodal smart textile
Creators: name: Lahmann, Nils A.
name: Müller-Werdan, Ursula
name: Kuntz, Simone
name: Klingehöfer-Noe, Jürgen
name: Jaenicke, Fabian
name: Strube-Lahmann, Sandra
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Smart textiles
subject: Nursing
subject: FOS: Health sciences
subject: Sensors
subject: Care
subject: Pulse
subject: Temperature
subject: Body position
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Smart textiles can support people with specific needs and diseases, such as diabetes or heart disease. Currently there are efforts to combine continuous mobile monitoring with other health-related conditions. On this basis, algorithms could be developed that can be used to detect unusual or critical conditions. A study was to investigate whether a previously developed washable Multi-Modal Smart Textile (MMST), based on inexpensive materials, would provide valid and reliable results with regard to the vital parameters of pulse, temperature and mobility. The measurement of the vital parameters was carried out with the developed prototype MMST as well as with validated devices. All electronics including the rechargeable NiMH has been washed more than 30 times with different methods and it remained fully functional. The intraclass correlation coefficients (ICC) for pulse (temperature) measurement ranged between 0.036 and 0.232 (0.077 and 0.817) depending on the activity of the tested individuals (standing, sitting, lying down, moving). Cohen's Kappa for the detection of the body position was 0.765. For the parameter of pulse, the results indicated an insufficient derivation for both validity and reliability. Due to flaws in the methodology applied, the validly and reliably for the parameter of temperature could not be determined. Valid and reliable results were obtained for the parameter mobility/change of position. If the MMST (after modification of the prototype) achieves reliable results, there are many advantages for people giving and receiving care on a budget price, even in threatening emergency situations.
Prevalence of Autism Spectrum Disorders in Guanajuato, Mexico: The Leon survey
Creators: name: Bruno, Ruth
name: Manero, Ana Cecilia
name: Marcin, Carlos
name: Fombonne, Eric
name: Nealy, Benjamin
name: Ramsay, Katrina
name: Villalobos, Michele
name: Diaz, Christian
Publisher: name: Springer Nature
Year: 2016

description: There are no epidemiological data on autism for Mexico. This study was conducted to generate a first estimate of ASD prevalence in Mexico. We surveyed children age eight in Leon (Guanajuato). The sample was stratified in two strata: (1) children having special education and medical records (SEMR; N = 432) and (2) children attending regular schools (GSS; N = 11,684). GSS children were screened with the SRS and those with the highest scores were invited to a diagnostic evaluation. The final sample comprised 36 children (80.6 % male) who had confirmed ASD. A third had intellectual disability, 25 % were non-verbal, 69 % had co-occurring behavioral problems. The prevalence overall was 0.87 % (95 % CI 0.62, 1.1 %). This survey provides an estimate for ASD prevalence in Mexico that is consistent with recent studies.
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
Creators: name: Doehn, Jan-Moritz
name: Tabeling, Christoph
name: Biesen, Robert
name: Saccomanno, Jacopo
name: Madlung, Elena
name: Pappe, Eva
name: Gabriel, Frieder
name: Kurth, Florian
name: Meisel, Christian
name: Corman, Victor M.
name: Hanitsch, Leif G.
name: Treskatsch, Sascha
name: Heim, Kathrin
name: Stegemann, Miriam S.
name: Ruwwe-Glösenkamp, Christoph
name: Müller-Redetzky, Holger C.
name: Uhrig, Alexander
name: Somasundaram, Rajan
name: Spies, Claudia
name: Bernuth, Horst Von
name: Hofmann, Jörg
name: Drosten, Christian
name: Suttorp, Norbert
name: Witzenrath, Martin
name: Sander, Leif E.
name: Hübner, Ralf-Harto
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: COVID-19
subject: SARS-CoV-2
subject: CD169
subject: SIGLEC1
subject: Type I interferons
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
title: Investigating Trophic Linkages for a Neotropical Migratory Bird: Molecular Identification of Food Items and Validation of a Protocol for Molecular Studies of Avian Diets
Creators: name: McCoskey, Dana N
Publisher: name: George Mason University
Year: 2017
Subjects: subject: DNA barcoding
subject: Molecular scatology
subject: Avian conservation
subject: Next-generation sequencing
subject: Diet
subject: Wood thrush

description: This thesis has been embargoed for 1 year. It will not be available until Decemberl 2017 at the earliest.
description: This thesis describes and validates a molecular method and its use for identifying food items in the diet of an omnivorous Neotropical migratory bird, the wood thrush (Hylocichla mustelina). Ecological understanding of niche, trophic interactions and the linkages in food webs are limited by difficulties in making accurate and efficient field observations of foraging behaviors and food choices to describe the diets of individual species within an ecosystem. To investigate the use of new methods to inform such ecological topics, a protocol based on DNA barcoding and Next Generation Sequencing was developed to utilize field collected scat samples to identify components of the wood thrush’s diet and to estimate diet diversity in temperate forests during the wood thrush’s breeding season. Comparisons of DNA sequences from diet items generated from scats were compared to concurrently collected stomach contents from the same individuals, as a primary means of validating the method to quantify that genetic information is indeed lost during digestion. To further test the efficacy of this molecular method, a secondary validation step compared molecular results from both stomach and scat samples to results obtained by a visual inspection of the same samples, where diet information was accessed by morphology of partially digested arthropod remains. These tests showed DNA barcoding of prey communities can provide a wealth of information on avian diet, and the use of additional markers provides an added benefit of detecting unique families and providing more diversity information. However, interpretation of species presence and absence information made by researchers should proceed with caution, since the types of species detected, varied by method, and some species detected in samples with a traditional morphological method were not detected with molecular techniques.
The Simultaneous Presence of Isolated Tumour Cells and Bone Marrow Micrometastases in Stage I and II Colon Cancer—Challenging the Theory of a Chronological Pathway of Tumour Cell Dissemination
Creators: name: Ramser, Michaela
name: Warschkow, Rene
name: Viehl, Carsten T.
name: Kettelhack, Christoph
name: Zettl, Andreas
name: Lobbes, Leonard A.
name: Zuber, Markus
name: Weixler, Benjamin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Stage I and II Colon Cancer
subject: Isolated Tumour Cells
subject: Bone Marrow Micrometastases
subject: Tumour Cell Dissemination
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: According to the common tenet, tumour progression is a chronological process starting with lymphatic invasion. In this respect, the meaning of bone marrow micrometastases (BMM) in patients with lymph node negative colon cancer (CC) is unclear. This study examines the relationship of isolated tumour cells (ITC) in sentinel lymph nodes (SLN) and BMM in patients in early CC. Methods: BM aspirates were taken from both pelvic crests and in vivo SLN mapping was done during open oncologic colon resection in patients with stage I and II CC. Stainings were performed with the pancytokeratin markers A45-B/B3 and AE1/AE3 as well as H&E. The correlation between the occurrence of ITC+ and BMM+ and their effects on survival was examined using Cox regression analysis. Results: In a total of 78 patients with stage I and II CC, 11 patients (14%) were ITC+, 29 patients (37%) BMM+. Of these patients, only two demonstrated simultaneous ITC+ /BMM+. The occurrence of BMM+ was neither associated with ITC+ in standard correlation (kappa = - 0.13 [95% confidence interval [CI] = - 0.4-0.14], p = 0.342) nor univariate (odds ratio [OR] = 0.39, 95%CI:0.07-1.50, p = 0.180) or multivariate (OR = 0.58, 95%CI: 0.09-2.95, p = 0.519) analyses. Combined detection of ITC+ /BMM+ demonstrated the poorest overall (HR = 61.60, 95%CI:17.69-214.52, p = 0.032) and recurrence free survival (HR = 61.60, 95%CI: 17.69-214.5, p = 0.032). Conclusions: These results indicate that simultaneous and not interdependent presence of very early lymphatic and haematologic tumour spread may be considered as a relevant prognostic risk factor for patients with stage I and II CC, thereby suggesting the possible need to reconsider the common assumptions on tumour spread proposed by the prevalent theory of sequential tumour progression.
title: Does Virtual Communication Equal Virtual Collaboration? The Influence of Technology on Job Satisfaction and Collaboration
Creators: name: Butler, Kathy
name: Perini, Michael
Publisher: name: Colorado Library Consortium (CLiC)
Year: 2015
Subjects: subject: Virtual reference
subject: Communication
subject: Job satisfaction

description: Library professionals are facing the same increasing pervasiveness of technology as other professions. Technology gives librarians positive new tools for managing and delivering information, but also changes modes of communication and collaboration with our patrons. This qualitative study explores the connection between the influx of virtual communication and its impact on collaboration and job satisfaction among academic librarians.
Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa
Creators: name: Dommisch, Henrik
name: Stolte, Kim Natalie
name: Jager, J.
name: Vogel, K.
name: Müller, R.
name: Hedtrich, S.
name: Unbehauen, M.
name: Haag, R.
name: Danker, K.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Core-multishell nanocarrier
subject: Transepithelial resistance
subject: Penetration
subject: Oral mucosal equivalents
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Topical drug administration is commonly applied to control oral inflammation. However, it requires sufficient drug adherence and a high degree of bioavailability. Here, we tested the hypothesis whether an ester-based core-multishell (CMS) nanocarrier is a suitable nontoxic drug-delivery system that penetrates efficiently to oral mucosal tissues, and thereby, increase the bioavailability of topically applied drugs. Material and methods: To evaluate adhesion and penetration, the fluorescence-labeled CMS 10-E-15-350 nanocarrier was applied to ex vivo porcine masticatory and lining mucosa in a Franz cell diffusion assay and to an in vitro 3D model. In gingival epithelial cells, potential cytotoxicity and proliferative effects of the nanocarrier were determined by MTT and sulphorhodamine B assays, respectively. Transepithelial electrical resistance (TEER) was measured in presence and absence of CMS 10-E-15-350 using an Endohm-12 chamber and a volt-ohm-meter. Cellular nanocarrier uptake was analyzed by laser scanning microscopy. Inflammatory responses were determined by monitoring pro-inflammatory cytokines using real-time PCR and ELISA. Results: CMS nanocarrier adhered to mucosal tissues within 5 min in an in vitro model and in ex vivo porcine tissues. The CMS nanocarrier exhibited no cytotoxic effects and induced no inflammatory responses. Furthermore, the physical barrier expressed by the TEER remained unaffected by the nanocarrier. Conclusions: CMS 10-E-15-350 adhered to the oral mucosa and adhesion increased over time which is a prerequisite for an efficient drug release. Since TEER is unaffected, CMS nanocarrier may enter the oral mucosa transcellularly. Clinical relevance: Nanocarrier technology is a novel and innovative approach for efficient topical drug delivery at the oral mucosa.
Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors
Creators: name: Eissa, Ibrahim H.
name: Elkady, Hazem
name: Elgammal, Walid E.
name: Mahdy, Hazem A.
name: Elshennawy, Hany S.
name: Husein, Dalal Z.
name: Amin, Fatma G.
name: Ibrahim, Ibrahim M.
name: Alsfouk, Bshra A.
name: Elkaeed, Eslam B.
name: Metwaly, Ahmed M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Thiadiazole-sulfonamide derivatives were synthesized as dual inhibitors of epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) to develop selective anticancer agents. Cytotoxicity was evaluated against MDA-MB-231 and MCF-7 breast cancer cells, with selectivity tested on Vero cells. Enzymatic inhibition studies were conducted against EGFR and CA-IX, using erlotinib and acetazolamide as reference drugs. Apoptosis was assessed through gene expression analysis of BAX/Bcl-2, caspase-8, and caspase-9, alongside flow cytometry for apoptosis and cell cycle analysis. Molecular docking and 200 ns molecular dynamics (MD) simulations evaluated binding interactions. Density Functional Theory (DFT) calculations and in silico ADMET predictions assessed stability, electronic properties, and safety. Compound 14 exhibited potent cytotoxicity (IC₅₀ = 5.78 μM, MDA-MB-231; 8.05 μM, MCF-7) and high selectivity (IC₅₀ = 313.08 μM, Vero). It inhibited EGFR (IC₅₀ = 5.92 nM) and CA-IX (IC₅₀ = 63 nM), surpassing reference drugs. Apoptosis induction was confirmed by a 13.97-fold increase in BAX/Bcl-2, caspase upregulation, and G1-phase arrest. Computational analyses confirmed stable binding and favorable safety. Compound 14 represents a promising dual EGFR/CA-IX inhibitor with selective anticancer activity. Further in vivo studies are warranted.
Side by Side: Friendship as Critical Practice in the Performance Art of Senga Nengudi and Maren Hassinger
Creators: name: Bowles, John P.
Publisher: name: Johns Hopkins University Press
Year: 2016

description: Artists Senga Nengudi and Maren Hassinger commemorated their friendship in 2006 by
making a collaborative video, Side by Side, surveying thirty years of creative dialogue and
exchange. Reflecting on the importance of having supported each other’s work since they
met in 1970s Los Angeles, the artists present a succession of video clips and photographs
documenting their participation in each other’s performances. As a result, Hassinger and
Nengudi introduce friendship as a crucial condition for the production and reception
of their work. To mark the significance of the occasion, Hassinger wrote a “Manifesto”
emphasizing how important it has been to develop their practices together in solidarity,
“side by side,” exchanging ideas and supporting each other during difficult times
[Letter from Shan Yuan to Hu Fengzhuo]
[單元致胡峯卓的信]
Creators: name: Shan, Yuan
Publisher: name: The University of British Columbia
Year: 2011

description: Shan Yuan mentions the Goose Mountain Ancestral Tomb lawsuit between the Hu and Nie clans, the renovation of Si Cheng School and needing money to send to Lianzhi who is severely sick in the hospital.
title: Application of Hydrogel Nanoparticles for Detection of Dengue Virus
Creators: name: Lee, Ji-Hyun
Publisher: name: George Mason University
Year: 2018
Subjects: subject: Dengue virus
subject: CN1030
subject: Enhanced detection
subject: Nanotrap particles

description: This thesis has been embargoed for 6 months and will not be available until June 2018 at the earliest.
description: Dengue infection is one of the most important mosquito-borne viral diseases whose origins can be tracked to hundreds of years ago. Over the years, the infection numbers and range have spread widely with significant amplification in the number of incidents and epidemics occurring. Factors, such as misdiagnosis, have been a contributing problem in our ability to control the incidence of disease across the world. Although there are diagnostic methodologies to detect dengue infection, many existing methods are not sensitive enough to detect early infections, making it possible to have many false-negatives. With no FDA approved vaccines or therapeutic options for treatment of dengue infection related disease manifestations including Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), there has been increasing interest to find a sensitive assay to detect and quantify virus, especially at the early stages of infection. As viral titers at the early stages of infection is too low to diagnose with current diagnostic methodologies, we hypothesize that Nanotrap sample preparation technology will enable enhanced detection at the lower limits of the virus using RT-qPCR. Nanotrap technology are hydrogel particles that have been engineered and tailored with specific size-sieving shell and chemical dye baits. In this study, four types of Nanotrap particles were screened to identify a particle architecture that best enriches DENV-2: CN1030, CN2010, CN2080, and CN400. CN1030 has a reactive red bait without a shell, CN2010 has a cibacron blue bait with a shell, CN1080 has an acrylic acid bait with a shell, and CN400 is a 1:1:1 ratio of CN1030, CN2010, and CN1080. Out of these Nanotrap particles, CN1030 have been found to provide the best enrichment of DENV-2 from our initial Nanotrap particles screening experiment yielding with a 10-fold enrichment. Using CN1030, we further tested limit of detection range and compared the detection range of the DENV-2 with and without CN1030. We found in absence of CN1030, DENV-2 was detected at 1.00E1 PFU/mL, but with CN1030 DENV-2 was detected at 1.00E-1 PFU/mL; this shows a 100-fold enrichment in detection. Ongoing studies are evaluating these particles for their ability to capture and enrich the other serotypes of DENV, namely DENV-1, -3, and -4 from urine. In addition, the ability of these particles to stabilize and preserve virus is also being evaluated, using DENV-2 as a prototype.
PHI density prospectively improves prostate cancer detection
Creators: name: Stephan, Carsten
name: Jung, Klaus
name: Lein, Michael
name: Rochow, Hannah
name: Friedersdorff, Frank
name: Maxeiner, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Prostate health index (PHI)
subject: PHI density (PHID)
subject: Prostate cancer
subject: Decision curve analysis (DCA)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: To evaluate the Prostate Health Index (PHI) density (PHID) in direct comparison with PHI in a prospective large cohort. Methods: PHID values were calculated from prostate-specific antigen (PSA), free PSA and [- 2]proPSA and prostate volume. The 1057 patients included 552 men with prostate cancer (PCa) and 505 with no evidence of malignancy (NEM). In detail, 562 patients were biopsied at the Charite Hospital Berlin and 495 patients at the Sana Hospital Offenbach. All patients received systematic or magnetic resonance imaging (MRI)/ultrasound fusion-guided biopsies. The diagnostic accuracy was evaluated by receiver operating characteristic (ROC) curves comparing areas under the ROC-curves (AUC). The decision curve analysis (DCA) was performed with the MATLAB Neural Network Toolbox. Results: PHID provided a significant larger AUC than PHI (0.835 vs. 0.801; p = 0.0013) in our prospective cohort of 1057 men from 2 centers. The DCA had a maximum net benefit of similar to 5% for PHID vs. PHI between 35 and 65% threshold probability. In those 698 men within the WHO-calibrated PSA grey-zone up to 8 ng/ml, PHID was also significantly better than PHI (AUC 0.819 vs. 0.789; p = 0.0219). But PHID was not different from PHI in the detection of significant PCa. Conclusions: Based on ROC analysis and DCA, PHID had an advantage in comparison with PHI alone to detect any PCa but PHI and PHID performed equal in detecting significant PCa.