cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells
Creators: name: Schöl, Marie
name: Schempp, Rebekka
name: Hennig, Thomas
name: Wigger, Dominik
name: Schumacher, Fabian
name: Kleuser, Burkhard
name: Stigloher, Christian
name: Ham, Marco Van
name: Jänsch, Lothar
name: Schneider-Schaulies, Sibylle
name: Dölken, Lars
name: Avota, Elita
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: neutral sphingomyelinase 2 (nSMase2)
subject: tumor necrosis factor-alpha (TNF-alpha)
subject: proximity labeling
subject: APEX2
subject: proteomics
subject: ceramide
subject: plasma membrane (PM)
subject: protein dynamic
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Ceramides generated by the activity of the neutral sphingomyelinase 2 (nSMase2) play a pivotal role in stress responses in mammalian cells. Dysregulation of sphingolipid metabolism has been implicated in numerous inflammation-related pathologies. However, its influence on inflammatory cytokine-induced signaling is yet incompletely understood. Here, we used proximity labeling to explore the plasma membrane proximal protein network of nSMase2 and TNFα-induced changes thereof. We established Jurkat cells stably expressing nSMase2 C-terminally fused to the engineered ascorbate peroxidase 2 (APEX2). Removal of excess biotin phenol substantially improved streptavidin-based affinity purification of biotinylated proteins. Using our optimized protocol, we determined nSMase2-proximal biotinylated proteins and their changes within the first 5 min of TNFα stimulation by quantitative mass spectrometry. We observed significant dynamic changes in the nSMase2 microenvironment in response to TNFα stimulation consistent with rapid remodeling of protein networks. Our data confirmed known nSMase2 interactors and revealed that the recruitment of most proteins depended on nSMase2 enzymatic activity. We measured significant enrichment of proteins related to vesicle-mediated transport, including proteins of recycling endosomes, trans-Golgi network, and exocytic vesicles in the proximitome of enzymatically active nSMase2 within the first minutes of TNFα stimulation. Hence, the nSMase2 proximal network and its TNFα-induced changes provide a valuable resource for further investigations into the involvement of nSMase2 in the early signaling pathways triggered by TNFα.
sj-pdf-1-ome-10.1177_0030222820926771 - Supplemental material for Cross-Sectional Research Into People Passing Away Through Self-Ingesting Self-Collected Lethal Medication After Receiving Demedicalized Assistance in Suicide
Creators: name: Hagens, Martijn
name: H. Roeline W. Pasman
name: Onwuteaka-Philipsen, Bregje D.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-ome-10.1177_0030222820926771 for Cross-Sectional Research Into People Passing Away Through Self-Ingesting Self-Collected Lethal Medication After Receiving Demedicalized Assistance in Suicide by Martijn Hagens, H. Roeline W. Pasman and Bregje D. Onwuteaka-Philipsen in OMEGA–Journal of Death and Dying
Studying the Intrinsic Reactivity of Chromanes by Gas-Phase Infrared Spectroscopy
Creators: name: Kirschbaum, Carla
name: Greis, Kim
name: Torres-Boy, América Y.
name: Riedel, Jerome
name: Gewinner, Sandy
name: Schöllkopf, Wieland
name: Meijer, Gerard
name: Helden, Gert Von
name: Pagel, Kevin
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Chemical structure
subject: Fragmentation
subject: Infrared light
subject: Ions
subject: Reaction mechanisms
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Tandem mass spectrometry is routinely used for the structural analysis of organic molecules, but many fragmentation reactions are not well understood. Because several potential structures can correspond to a measured mass, the assignment of product ions is ambiguous using mass spectrometry alone. Here, we combine mass spectrometry with high-resolution gas-phase infrared spectroscopy and computational chemistry tools to identify product ion structures and derive collision-induced fragmentation mechanisms of the chromane derivatives Trolox and Methyltrolox. We find that protonated Trolox and Methyltrolox fragment identically via dehydration and decarbonylation, while deprotonated ions display substantially diverging reactivities. For deprotonated Methyltrolox, we observe unusual radical fragmentation reactions and suggest a [1,2]-Wittig rearrangement involving aryl migration in the gas phase. Overall, the combined experimental and theoretical approach presented here revealed complex proton dynamics and intramolecular rearrangement reactions, which expand our understanding on structure–reactivity relationships of isolated molecules in different protonation states.
title: Contemporary political performing arts in South Africa.
Creators: name: Dontsa, Luvuyo
Publisher: name: SOAS University of London
Year: 1990

description: Despite the fact that 'transculturation' between Africans and Europeans in South Africa has been going on for more than two centuries, African contemporary political performing arts continually reflect indigenous performing arts' genres of the pre-colonial era. Although a contemporary political performing artist does not play exactly the same role that is played by the traditional artist, who 'criticises the chiefs for perverting the laws and the customs of the nation and laments their abuse of power and neglect of their responsibilities and obligations to the people' (Mafeje, 1967: 195), he still represents the public: in this case a much wider public, and expresses the views which are shared by Africans throughout the whole country. The thesis surveys the political roles of contemporary African performing arts in South Africa. It demonstrates how performing arts have been systematically used as a mechanism to 'step in arenas' where one would dare not with political vehicle, and conveying political messages to promote the struggle for national liberation. The work shows the unique manner in which political performing arts are implemented, and to what degree they have succeeded. It also reveals an element of fear among both Africans and Europeans as being an overt manifestation of the national struggle by the Africans, which has resulted in harassments and detentions of the former, and the loss of privileges to the latter. Lastly, it reflects frustration among the Africans, as their endeavours for national liberation are thwarted. The research has covered the techniques employed by the performing artists to convey political messages. It also assesses the relationship between the traditional and the avant-garde (non-conventional) performing arts, and evaluates the reasons for the change in tactics. Reactions of resentment to change in cultural and social life are discussed; how the Government has ruthlessly responded to such addresses; and how people have reacted to harsh response from the Government. The work also reveals how performing arts have appealed for international attention to address the South African situation, and how international artists have used an international forum to highlight the South African situation. Lastly, the work analyses South African contemporary political performing arts in worldwide context.
At the Nexus of Design and Entrepreneurship: Exploring Designer-founders’ Practices, Identities, and Learning
Creators: name: Klenner, Nico
Publisher: name: RMIT University
Year: 2024
Subjects: classificationCode: 350704
subject: Entrepreneurship
classificationCode: 350605
subject: Marketing management (incl. strategy and customer relations)
classificationCode: 330305
subject: Design management

description: How can we meaningfully connect the domains of design and entrepreneurship? One way of shedding light on the nexus of design and entrepreneurship is to study designer-founders, i.e., designers who have ventured out into entrepreneurship and started a new venture. The present dissertation makes three significant contributions: (1) The dissertation explains how designer-founders practice designerly ways of entrepreneuring and entrepreneurial ways of designing, (2) the dissertation shows how designer founders attenuate and embrace identity tensions through self-mandated identity work, and (3) the dissertation clarifies how designer-founders leverage reflective practice to engage in business model innovation and continuous learning. By exploring the practices, identities, and learning of designer-founders, the dissertation advances our understanding of the nexus of design and entrepreneurship in theory and practice.
Dynamics of HIV PrEP use and coverage during and after COVID-19 in Germany
Creators: name: Schmidt, Daniel
name: Duport, Yannick
name: Kollan, Christian
name: Marcus, Ulrich
name: Iannuzzi, Sara
name: Kleist, Max Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: HIV-PrEP users
subject: COVID-19
subject: Germany
subject: PrEP need
subject: PrEP coverage
subject: Pharmaceutical prescription data
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Background Pre-exposure prophylaxis (PrEP) with oral emtricitabine/tenofovir disoproxil (FTC/TDF) proved highly efficient in preventing HIV. Since 09/2019, FTC/TDF-PrEP is covered by health insurances in Germany, if prescribed by licensed specialists. However, methods to longitudinally monitor progress in PrEP implementation in Germany are lacking. Methods Utilizing anonymous FTC/TDF prescription data from 2017-2021, we developed a mathematical model to disentangle HIV-treatment from PrEP prescriptions, as well as to translate PrEP prescriptions into number of PrEP users. We used the model to estimate past- and future PrEP uptake dynamics, to predict coverage of PrEP needs and to quantify the impact of COVID-19 on PrEP uptake on a national and regional level. Results We identified significant (p<0.01) decelerating effects of the first- and second COVID-19-lockdown on PrEP uptake in 04/2020 and 12/2020. We estimated 26,159 (CI: 25,751-26,571) PrEP users by 12/2021, corresponding to 33% PrEP coverage of people in need. We projected 64,794 (CI: 62,956-66,557) PrEP users by 12/2030, corresponding to 81% PrEP coverage. We identified profound regional differences, with high PrEP coverage and uptake in metropoles and low coverage in more rural regions. Conclusions Our approach presents a comprehensive solution to monitor and forecast PrEP implementation from anonymous data and highlighted that the COVID-19 pandemic significantly decelerated PrEP uptake in Germany. Moreover, slow PrEP uptake in rural areas indicate that structural barriers in PrEP care, education or information exist that may hamper the goal of ending the AIDS epidemic by 2030.
title: The Shia Imami Ismailia community in Britain.
Creators: name: Hallam, Roger N.M.
Publisher: name: SOAS University of London
Year: 1971

description: The subject of this thesis is the organisation of the Shia Imami Ismailis in Britain. Part I is concerned with certain background topics. Chapter 1 touches on the history of Ismailisia in general, including how it came to India, and on points of doctrine which can best be understood in this context. The next three chapters of part I consider respectively religious, administrative and financial aspects of Ismaili organisation in East Africa as it has been developed during the twentieth century. The last chapter in part I discusses in greater detail the role of the imam (Aga Khan) in promoting change among his followers. The relevance of some of these developments for settlement in Britain is suggested. The first chapter of part II (chapter 6) describes the pattern to Ismaili migration to Britain, and how the composition of this migration changed over the years. Something of the resultant social diversity among Ismailis in Britain is suggested in chapter 7, though here the emphasis is on diversity in terms of British social classifications. In chapter 8 some detailed case histories are set out in an attempt to bring out the altered significance of collective Ismaili organisation in Britain. At this point the question of exogamy is also considered. The Ismaili council in Britain, based on the London mosque, forms the subject of chapter 9; comparison with its East African counterparts argues the weakness of the British council, and some of the reasons are suggested. The concluding chapter 10 looks tentatively at the Ismaili migration to Britain in terms of the changing basis of community economic activity in East Africa in the light of the post-independence situation there, and also discusses the structure of the Ismaili organisation in Britain, examining the decline in collective organisation and the social fragmentation of Ismailis here.
QUADRILINGUAL SECRETARY FOR INTERPOL - ADAPTABILITY TO DIFFERENT WORK ENVIRONMENTS
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Adaptability
Quadrilingual
Corporate culture
Startup culture
International organizations
Interpol
Remote work
Cultural sensitivity
Continuous learning
Flexibility

description: This article explores the critical role of adaptability for a quadrilingual secretary navigating the distinct environments of corporate and startup cultures, with a focus on an international organization like Interpol. The analysis delves into the challenges and strategies required to adjust to varying management styles, handle unpredictable situations, and thrive in remote work settings. It emphasizes the importance of cultural sensitivity in international office dynamics, the need for continuous learning in adapting to new tools and technologies, and the balance between autonomy and team integration. Ultimately, the article highlights the significance of flexibility and proactive problem-solving in ensuring effective performance across diverse professional landscapes.
First evaluation and detection of ivermectin resistance in gastrointestinal nematodes of sheep and goats in South Darfur, Sudan
Creators: name: Mohammedsalih, Khalid M.
name: Ibrahim, Abdoelnaim I. Y.
name: Juma, Fathel-Rahman
name: Abdalmalaik, Abdalhakaim A. H.
name: Bashar, Ahmed
name: Coles, Gerald
name: Samson-Himmelstjerna, Georg Von
name: Krücken, Jürgen
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Nematode infections
subject: Eggs
subject: Sheep
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: In Sudan, resistance to benzimidazoles has been reported recently in cattle and goats from South Darfur. Herein, ivermectin efficacy against gastrointestinal nematodes (GINs) was evaluated in sheep and goats in three study areas in South Darfur. The faecal egg count reduction test (FECRT) was used to evaluate the efficacy of ivermectin in sheep and goats naturally infected with GINs in the region of Bulbul (goats: n = 106), Kass (goats: n = 40) and Nyala (Domaia (sheep: n = 47, goats: n = 77) and the University farm (goats: n = 52)), using different treatment plans, and the efficacy was evaluated 12 days after treatment. Ivermectin efficacy was also evaluated in goats experimentally infected using local Haemonchus contortus isolates from Kass and Nyala. Nematodes surviving ivermectin treatment in goats in Bulbul and Nyala were harvested and larvae used to infect worm-free male sheep (n = 6, ≤6 months old). Infected sheep were dosed subcutaneously with ivermectin every eight days with increasing doses from 0.2 mg/kg to 1.6 mg/kg bodyweight (bw). Reduced ivermectin efficacy was identified in sheep and goats in the four study locations. Using a paired statistic, the efficacy of a therapeutic dose in sheep was 75.6% (90% upper credible limit (UCrL): 77.5%), while twice the recommended dose led to a reduction of 92.6% (90% UCrL: 93.3%). In goats, the FECRs of a therapeutic dose were 72.9–95.3% (90% UCrL range: 73.6–95.7%) in Bulbul, Nyala Domaia, Nyala University farm and Kass. Twice the dose recommended for goats in Bulbul revealed a 90% UCrL of 87.6%. All post-treatment faecal cultures contained only Haemonchus spp. larvae. The experimental infection trials in sheep and goats supported our findings from field trials and calculated upper 90% CrL of below 98.9%. For the first time highly ivermectin resistant H. contortus populations have been identified in sheep and goats in Sudan, and resistance was experimentally confirmed.
An integral assessment of the impact of diet and manure management on whole-farm greenhouse gas and nitrogen emissions in dairy cattle production systems using process-based models
Creators: name: Ouatahar, Latifa
name: Bannink, André
name: Zentek, Jürgen
name: Amon, Thomas
name: Deng, Jia
name: Hempel, Sabrina
name: Janke, David
name: Beukes, Pierre
name: Weerden, Tony Van Der
name: Krol, Dominika
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Dairy production systems
subject: Feed management
subject: Greenhouse gas emissions
subject: Process-based modeling
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Feed management decisions are crucial in mitigating greenhouse gas (GHG) and nitrogen (N) emissions from ruminant farming systems. However, assessing the downstream impact of diet on emissions in dairy production systems is complex, due to the multifunctional relationships between a variety of distinct but interconnected sources such as animals, housing, manure storage, and soil. Therefore, there is a need for an integral assessment of the direct and indirect GHG and N emissions that considers the underlying processes of carbon (C), N and their drivers within the system. Here we show the relevance of using a cascade of process-based (PB) models, such as Dutch Tier 3 and (Manure)-DNDC (Denitrification-Decomposition) models, for capturing the downstream influence of diet on whole-farm emissions in two contrasting case study dairy farms: a confinement system in Germany and a pasture-based system in New Zealand. Considerable variation was found in emissions on a per hectare and per head basis, and across different farm components and categories of animals. Moreover, the confinement system had a farm C emission of 1.01 kg CO2-eq kg−1 fat and protein corrected milk (FPCM), and a farm N emission of 0.0300 kg N kg−1 FPCM. In contrast, the pasture-based system had a lower farm C and N emission averaging 0.82 kg CO2-eq kg−1 FPCM and 0.006 kg N kg−1 FPCM, respectively over the 4-year period. The results demonstrate how inputs and outputs could be made compatible and exchangeable across the PB models for quantifying dietary effects on whole-farm GHG and N emissions.
title: Exploring for the Future - An overview of Australia’s transformational geoscience program
Creators: name: L., Gow
name: Geoscience Australia
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2024
Subjects: subject: EARTH SCIENCES
subject: EFTF - Exploring for the Future
subject: Officer-Musgrave-Birrindudu
subject: National Groundwater Systems
subject: Darling-Curnamona-Delamerian
subject: Australia’s Resources Framework
subject: Australia’s Future Energy Resources
subject: Barkly-Isa-Georgetown
subject: Geoscience Knowledge Sharing
subject: Enhanced Data Delivery
subject: precompetitive geoscience
subject: groundwater
subject: Minerals
subject: Published_External

description: Australia remains underexplored or unexplored, boasting discovery potential in the mineral, groundwater, and energy resources hidden beneath the surface. These “greenfield” areas are key to Australia’s future prosperity and sustainability.

Led by Geoscience Australia, Australia’s national government geoscience organisation, the Exploring for the Future program was a groundbreaking mission to map Australia’s mineral, energy, and groundwater systems in unparalleled scale and detail. The program has advanced our understanding of Australia’s untapped potential.

Over the course of 8 years, the Exploring for the Future program provided a significant expansion of public, precompetitive geoscience data and information, equipping decision-makers with the knowledge and tools to tackle urgent challenges related to Australia’s resource prosperity, energy security, and groundwater supply.
Reduced Protein Stability of 11 Pathogenic Missense STXBP1/MUNC18-1 Variants and Improved Disease Prediction
Creators: name: André, Timon
name: Berkel, Annemiek A. Van
name: Singh, Gurdeep
name: Abualrous, Esam Tolba
name: Diwan, Gaurav D.
name: Schmenger, Torsten
name: Braun, Lara
name: Malsam, Jörg
name: Toonen, Ruud F.
name: Freund, Christian
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Aggregation
subject: Exocytosis
subject: Machine learning
subject: MUNC18-1
subject: Protein stability
subject: Syntaxin
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Background Pathogenic variants in STXBP1/MUNC18-1 cause severe encephalopathies that are among the most common in genetic neurodevelopmental disorders. Different molecular disease mechanisms have been proposed, and pathogenicity prediction is limited. In this study, we aimed to define a generalized disease concept for STXBP1-related disorders and improve prediction. Methods A cohort of 11 disease-associated and 5 neutral variants (detected in healthy individuals) were tested in 3 cell-free assays and in heterologous cells and primary neurons. Protein aggregation was tested using gel filtration and Triton X-100 insolubility. PRESR (predicting STXBP1-related disorder), a machine learning algorithm that uses both sequence- and 3-dimensional structure–based features, was developed to improve pathogenicity prediction using 231 known disease-associated variants and comparison to our experimental data. Results Disease-associated variants, but none of the neutral variants, produced reduced protein levels. Cell-free assays demonstrated directly that disease-associated variants have reduced thermostability, with most variants denaturing around body temperature. In addition, most disease-associated variants impaired SNARE-mediated membrane fusion in a reconstituted assay. Aggregation/insolubility was observed for none of the variants in vitro or in neurons. PRESR outperformed existing tools substantially: Matthews correlation coefficient = 0.71 versus <0.55. Conclusions These data establish intrinsic protein instability as the generalizable, primary cause for STXBP1-related disorders and show that protein-specific ortholog and 3-dimensional information improve disease prediction. PRESR is a publicly available diagnostic tool.
Neuronal oscillations and functional connectivity of paced nostril breathing: A high-density EEG study
Creators: name: Frohlich, Flavio
name: Frohlich, Anita B.
name: Sklerov, Miriam
Publisher: name: Public Library of Science (PLoS)
Year: 2025

description:
Controlling nostril airflow through hand manipulations is an ancient yoga technique that has been suggested to provide targeted modulation of neuronal excitability and regulation of autonomic function, which is known to be lateralized in the brain. Here, we examined if unilateral and alternate nostril breathing differentially impacts brain network oscillations measured by high-density EEG in healthy control participants with no prior experience in breathing techniques. We found that paced nostril breathing both decreased alpha/mu oscillations over central and parietal areas and increased frontal midline and occipital theta oscillations when comparing to spontaneous breathing. Alternate nostril breathing suppressed alpha/mu oscillation more than left nostril breathing. Unilateral nostril breathing resulted in an ipsilateral increase in alpha connectivity while left nostril breathing increased anterior-posterior midline theta connectivity. In contrast to the EEG results, heart rate, heart rate variability, and cognitive performance assessed with a working memory task did not differ significantly by breathing condition. Our results add to the existent literature on nasal breathing by demonstrating changes in cortical oscillations and connectivity during a task that combined slow breathing with manual nasal pathway modulation.
title: The role of non-hydrocarbon minerals in the Arab Middle East: With special reference to the use of indigenous minerals in regional economic development.
Creators: name: Gurdon, Charles G.
Publisher: name: SOAS University of London
Year: 1989

description: Chapter One provides an introduction to the thesis and outlines a theoretical model of an impact study which enables the economic role of mining to be studied in the subsequent chapters. Chapter Two first analyses the geological formation of the Arab Middle East and then outlines the major nonhydrocarbon mineral deposits in the region. Chapter Three provides a brief history of mining in the region before reviewing current mineral production in each country. Chapter Four examines employment in the mining sector and highlights the differences between the countries of the region. Chapter Five deals with the volume and direction of mineral trade including downstream mineral products. Chapter Six uses the impact model to analyse the role of the mining sector in the national economies of the Arab Middle East. It shows that its role is significantly more important than it might initially appear. Chapter Seven studies the role of mining in regional economic development. It concentrates on four regions in the Arab Middle East which illustrate the various stages of mineral development. These are the Algerian-Tunisian frontier region, central Jordan, northern Oman and the Red Sea Hills of Sudan. Chapter Eight draws the strands of the thesis together and provides specific conclusions before suggesting future areas of research on non-hydrocarbon mining in the Arab Middle East.
Supplemental Material, Supplemental_Material_for_Advanced_High-Throughput_Imaging_Applications_of_Clonogenicity_in_Cancer_by_Esquer_et_al. - Advanced High-Content-Screening Applications of Clonogenicity in Cancer
Creators: name: Esquer, Hector
name: Zhou, Qiong
name: Abraham, Adedoyin D.
name: LaBarbera, Daniel V.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental Material, Supplemental_Material_for_Advanced_High-Throughput_Imaging_Applications_of_Clonogenicity_in_Cancer_by_Esquer_et_al. for Advanced High-Content-Screening Applications of Clonogenicity in Cancer by Hector Esquer, Qiong Zhou, Adedoyin D. Abraham and Daniel V. LaBarbera in SLAS Discovery
title: Exploring for the Future program Showcase 2024 - Day 1 Plenary & Discovery and Engagement
Creators: name: U., Czarnota
name: A., Heap
name: V., Normington
name: M., Sweeney
name: M., Orr
name: M., Webster
name: K., Waltenberg
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2024
Subjects: subject: EFTF – Exploring for the Future
subject: Enhanced Data Delivery
subject: Geoscience Knowledge Sharing
subject: stakeholder engagement
subject: indigenous engagement
subject: data portal
subject: Earth Sciences
subject: Published_External

description: The Exploring for the Future program Showcase 2024 was held on 13-16 August 2024.
Day 1 - 13th August talks included:
Plenary SessionExploring for the Future: innovative science at an unprecedented scale – Dr Andrew Heap
Session 2 - Geoscience for all AustraliansRocks that Shape Australia: Sharing stories of Australian geoscience through an exhibition - Dr Verity NormingtonField work and community engagement across the whole country - 8 years of learning - Margaret SweeneySharing geoscience for managing Country - Dr Meredith OrrDigital pathways for getting our science to users - Mark WebsterLaunch of the pilot GeoInsight application: A new digital hub for access to geological insights - Dr Kathryn Waltenburg
The recordings for these talks will be available in the coming days.
Modeling of HIV-1 prophylactic efficacy and toxicity with islatravir shows non-superiority for oral dosing, but promise as a subcutaneous implant
Creators: name: Kim, Hee-Yeong
name: Zhang, Lanxin
name: Hendrix, Craig W.
name: Haberer, Jessica E.
name: Kleist, Max Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: islatravir
subject: HIV-1 prophylactic efficacy
subject: toxicity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: HIV prevention with pre-exposure prophylaxis (PrEP) constitutes a major pillar in fighting the ongoing epidemic. While daily oral PrEP adherence may be challenging, long-acting (LA-)PrEP in oral or implant formulations could overcome frequent dosing with convenient administration. The novel drug islatravir (ISL) may be suitable for LA-PrEP, but dose-dependent reductions in CD4+ T cell and lymphocyte counts were observed at high doses. We developed a mathematical model to predict ISL pro-drug levels in plasma and active intracellular ISL-triphosphate concentrations after oral vs. subcutaneous implant dosing. Using phase II trial data, we simulated antiviral effects and estimated HIV risk reduction for multiple dosages and dosing frequencies. We then established exposure thresholds where no adverse effects on immune cells were observed. Our findings suggest that implants with 56–62 mg ISL offer effective HIV risk reduction without reducing lymphocyte counts. Oral 0.1 mg daily, 3–5 mg weekly, and 10 mg biweekly ISL provide comparable efficacy, but weekly and biweekly doses may affect lymphocyte counts, while daily dosing regimen offered no advantage over existing oral PrEP. Oral 0.5–1 mg on demand provided > 90 % protection, while not being suitable for post-exposure prophylaxis. These findings suggest ISL could be considered for further development as a promising and safe agent for implantable PrEP.
Supplementary_Figures_S1 – Supplemental material for Synthesis, spectroscopic properties, crystal structures, DFT studies, and the antibacterial and enzyme inhibitory properties of a complex of Co(II) 3,5-difluorobenzoate with 3-pyridinol
Creators: name: Sertçelik, Mustafa
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, Supplementary_Figures_S1 for Synthesis, spectroscopic properties, crystal structures, DFT studies, and the antibacterial and enzyme inhibitory properties of a complex of Co(II) 3,5-difluorobenzoate with 3-pyridinol by Mustafa Sertçelik in Journal of Chemical Research
sj-pdf-1-aim-10.1177_0964528420920290 - Supplemental material for Effects of acupuncture on cardiovascular risks in patients with hypertension: a Korean cohort study
Creators: name: Hyejin Jung
name: Sujung Yeo
name: Lim, Sabina
Publisher: name: SAGE Journals
Year: 2020
Subjects: Medicine

description: Supplemental material, sj-pdf-1-aim-10.1177_0964528420920290 for Effects of acupuncture on cardiovascular risks in patients with hypertension: a Korean cohort study by Hyejin Jung, Sujung Yeo and Sabina Lim in Acupuncture in Medicine
Rethinking Human Nature: Bridging the ‘Gap’ through Landscape Analysis and Geographical Information Systems (GIS)
Creators: name: Lindholm, Karl-Johan
name: Hackwitz, Kim Von
name: Ekblom, Anneli
name: Löwenborg, Daniel
name: Ljungkvist, John
Publisher: name: Freie Universität Berlin
Year: 2015
Subjects: subject: Landscape
subject: archaeology
subject: landscape analysis
subject: GIS
subject: pedagogy
subject: Uppsala University
subject: 900 Geschichte und Geografie::930 Geschichte des Altertums (bis ca. 499), Archäologie::930 Geschichte des Altertums bis ca. 499, Archäologie

description: This paper will discuss a pedagogical approach to integrating the humanities and the natural sciences. Our approach calls for extended collaboration between the two fields and a capacity to integrate the experimental and deductive lines of reasoning within the natural sciences with the holistic and critical perspectives of the humanities. This paper will describe and discuss how this notion is applied to the construction of a pedagogical framework or a learning environment constituted from landscape theory, GIS, and pedagogical principles derived from EBL and PL. The paper highlights how a landscape approach in combination with the interactive and dynamic properties of GIS can be used as an active learning environment crossing the interfaces of the disciplines.
title: Some problems in the phonology of Old Japanese reconsidered in the light of comparative evidence from the Amami dialects.
Creators: name: Urakami, Junnosuke
Publisher: name: SOAS University of London
Year: 1989

description: This thesis focuses on the most controversial phonological problem in Old Japanese, the phonetic and phonological status of two types of syllables, found in written texts, known as the 'A/B-type' contrast. Previous approaches have centred around the phonetic evaluation of Middle Chinese characters, and examination of Pre-Old Japanese diphthongal sources reconstructed through the morpho-phonemic analysis of Old Japanese. All of these approaches have various limitations, since Old Japanese does not provide sufficient evidence to support the results thus gained. Recently attempts have been made to apply study of the Ryukyu dialects to the problem. In particular linguists have claimed that the Modern Amami dialects reflect the A/B-type distinction. The importance here lies in the fact that study within this field can provide firm empirical evidence. The present thesis, therefore, aims at shedding light on the A/B-type distinction by a study of the Modern Amami dialects, specifically by the reconstruction of the phonemes of Proto-Amami. Chapter One is an introduction, containing the argument in favour of undertaking this line of research, with details of the survey and informant information. Chapter Two contains a review of the Old Japanese A/B distinction, plus a survey of previous works in the field by Hashimoto, Arisaka, Lange, Unger, Ono, Matsumoto, Mori, etc. Problems to be dealt with in the present work are isolated. Chapter Three discusses the Ryukyu dialects, and focuses in on the importance of the Amami dialects. It concludes with a synchronic overview of the Amami dialects. Chapter Four contains the reconstruction of Proto-Amami phonemes, a synchronic description of Proto-Amami and sound changes. Chapter Five offers a sub-grouping of the Modern Amami dialects, with a tree diagram and isoglosses. Chapter Six contains a comparison of the Old Japanese A/B contrast with PA. Chapter Seven compares the results obtained for PA from Chapter Six with the work of past researchers, specifically Shibata. Chapter Eight is a summary of this work, plus suggestions for further work on Proto-Amami.
title: Untersuchungen zur Umfeldwahrnehmung mittels eines Dynamic Vision Sensor Systems im Kontext des automatisierten Fahrens
Creators: name: Hänsel, Leonard
name: Bertram, Torsten
Publisher: name: TU Ilmenau
Year: 2025
Subjects: subject: Automatisiertes Fahren
subject: Ereigniskamera
subject: Radar
subject: Sensorfusion
subject: Umfelderkennung
subject: Umfelderfassung
subject: Pixellichtsystem
subject: 621.3

description: Die visuelle Wahrnehmung ist eine wesentliche Komponente für das sichere Führen eines Fahrzeugs in jeder Verkehrssituation. Im Kontext des automatisierten Fahrens gilt es, diesen Prozess zu digitalisieren, um eine leistungsfähige Umfelderkennung zu realisieren. Konventionelle Kamerasensoren, die bisher weit verbreitet sind, stoßen hinsichtlich des Dynamikbereichs, der Geschwindigkeit und des Energieverbrauchs an ihre Grenzen. Dynamic Vision Sensoren (DVSen), auch Ereigniskameras genannt, bieten hier entscheidende Vorteile. Diese Sensoren erfassen zeitliche Helligkeitsänderungen in den beobachteten Szenen, wobei die Pixel unabhängig und asynchron voneinander arbeiten. Neben der visuellen Wahrnehmung durch Kameras haben sich verschiedene Sensorkonzepte für Fahrerassistenzsysteme entwickelt, darunter die Radio Detection and Ranging (Radar)-Technologie. Das System bietet die Möglichkeit, die Position des Objekts und die zugehörige Relativgeschwindigkeit zu erfassen. Im Rahmen des vorliegenden Beitrags werden die Vor- und Nachteile des Dynamic Vision Sensors ausführlich erläutert. Anschließend wird der Stand der Technik bei der Kombination von Dynamic Vision Sensoren und Radaren mittels Sensorfusion dargestellt und mögliche Forschungsinhalte anhand wissenschaftlicher Fragestellungen formuliert. Diesbezüglich werden die Vorteile der Fusion beider Sensorsysteme aufgezeigt und Herausforderungen bei der Umsetzung dieser Fusion diskutiert. Aus diesen Erkenntnissen wird ein Ausblick auf eine mögliche Erweiterung des Aufbaus durch ein Pixellichtsystem vorgeschlagen, um die Auflösung des Umfeldes weiter zu erhöhen.
description: Lux junior 2024: 17. Internationales Forum für den lichttechnischen Nachwuchs, 6. – 8. September 2024, Ilmenau : Tagungsband, p. 107
sj-pdf-1-mcr-10.1177_1077558720930131 - Supplemental material for Financial Vulnerability and Worker Well-Being: A Comparison of Long-Term Services and Supports Workers With Other Health Workers
Creators: name: Muench, Ulrike
name: Jura, Matthew
name: Spetz, Joanne
name: Mathison, Rachel
name: Herrington, Charlene
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-mcr-10.1177_1077558720930131 for Financial Vulnerability and Worker Well-Being: A Comparison of Long-Term Services and Supports Workers With Other Health Workers by Ulrike Muench, Matthew Jura, Joanne Spetz, Rachel Mathison, Charlene Herrington in Medical Care Research and Review
Sequencing accuracy and systematic errors of nanopore direct RNA sequencing
Creators: name: Liu-Wei, Wang
name: Toorn, Wiep Van Der
name: Bohn, Patrick
name: Hölzer, Martin
name: Smyth, Redmond P.
name: Kleist, Max Von
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Nanopore sequencing
subject: Direct RNA sequencing
subject: Transcriptomics
subject: Epitranscriptomics
subject: Sequencing errors
subject: Sequencing accuracy
subject: SQK-RNA004
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Background Direct RNA sequencing (dRNA-seq) on the Oxford Nanopore Technologies (ONT) platforms can produce reads covering up to full-length gene transcripts, while containing decipherable information about RNA base modifications and poly-A tail lengths. Although many published studies have been expanding the potential of dRNA-seq, its sequencing accuracy and error patterns remain understudied. Results We present the first comprehensive evaluation of sequencing accuracy and characterisation of systematic errors in dRNA-seq data from diverse organisms and synthetic in vitro transcribed RNAs. We found that for sequencing kits SQK-RNA001 and SQK-RNA002, the median read accuracy ranged from 87% to 92% across species, and deletions significantly outnumbered mismatches and insertions. Due to their high abundance in the transcriptome, heteropolymers and short homopolymers were the major contributors to the overall sequencing errors. We also observed systematic biases across all species at the levels of single nucleotides and motifs. In general, cytosine/uracil-rich regions were more likely to be erroneous than guanines and adenines. By examining raw signal data, we identified the underlying signal-level features potentially associated with the error patterns and their dependency on sequence contexts. While read quality scores can be used to approximate error rates at base and read levels, failure to detect DNA adapters may be a source of errors and data loss. By comparing distinct basecallers, we reason that some sequencing errors are attributable to signal insufficiency rather than algorithmic (basecalling) artefacts. Lastly, we generated dRNA-seq data using the latest SQK-RNA004 sequencing kit released at the end of 2023 and found that although the overall read accuracy increased, the systematic errors remain largely identical compared to the previous kits. Conclusions As the first systematic investigation of dRNA-seq errors, this study offers a comprehensive overview of reproducible error patterns across diverse datasets, identifies potential signal-level insufficiency, and lays the foundation for error correction methods.
title: Aspects of the phonology of the Sinhalese verb: A prosodic analysis.
Creators: name: Rajapaksa, Rajapaksa M.W.
Publisher: name: SOAS University of London
Year: 1988

description: The purpose of the thesis is to study Sinhalese verb forms in relation to slow and rapid styles. The theory used in the analysis is that of Prosodic Phonology. The thesis is presented in seven chapters and an appendix. Discussed in Chapter 1 are styles, speech situations, the theory used in the analysis, the choice of the theory as the theoretical background, the nature of the analysis, research procedure, data, informants, and new information arising from the research. Chapter 2 is divided into two parts. Part 1 is an outline description of vowel and consonant sounds. The physical characteristics of these sounds and their distribution are given here. Part 2 includes a discussion of the syllable: syllable structure, syllable quantity, syllable prominence and syllable division. Chapter 3 contains an analysis of simple verb stems. Structures and patterns of verb stems, and contrasts and functions of elements within patterns are given here. In the analysis of disyllabic structures, the relationship between the first and second syllables is also discussed. Included in chapter 4 is a phonological analysis of phrasal verb stems. Here, three types of stems, non-free morphemes, loan stems and onomatopoeic stems are described. At the end of each analysis, differences of the phonological structure of stems of the given three types are considered. In the analysis of the onomatopoeic stems, the relationship between the initial and non-initial syllables is also examined. Chapter 5 includes a phonological analysis of affixes which can be suffixes, infixes or prefixes. How phonological structures of affixes differ from those of stems is also discussed. Discussed in chapter 6 are the conjug. marker, conjug. classes, the relationship between non-past vol. and invol. stems and non-past and past vol. stems, junction prosodies, reduplication and the length relationship. The analysis of rapid verb forms is given in chapter 7. Here, stems and affixes are described separately. In the analysis, phonological structures of parallel slow forms of stems and affixes are also given for comparison with structures of rapid forms. This chapter is followed by a summary and conclusion. The appendix includes a grammatical analysis of verb forms and a list of simple verbs which are analyzed in the thesis. In the grammatical analysis, volitive and involitive forms, tenses, aspects, overlapping forms and the grammatical function of suffixes are discussed.
title: Examining Urdu: A study of 16+ examinations in the U.K.
Creators: name: Dodds, Martin C.L.
Publisher: name: SOAS University of London
Year: 1989

description: The purpose of this thesis is to investigate some aspects of Urdu examinations in Britain. The changeover from GCE to GCSE has required Urdu teachers and students to develop a broader range of skills. The goals of the Urdu-using community do not necessarily accord with the demands of the GCSE, which requires Urdu to be examined according to criteria determined for French. Chapter 1 discusses factors which affect the examination and distinguish Urdu from French: the students' bilingual background, teachers and teaching provision, the implications of the change in the examination system, the introduction of the National Curriculum and the notion of parity of status with 'Modern Languages'. Chapter 2 analyses the GCSE criteria and the Urdu syllabuses derived from them. Certain aspects of the GCSE are given special consideration, including writing standards, the oral examination, discrete-skill testing and the use of dual language papers. In view of the social priority accorded to writing by the Urdu-using community it was thought appropriate to investigate examination candidates' written performance. Chapter 3 discusses the rationale for the collection and analysis of the corpus analysed. Chapter 4 demonstrates the types and range of verbs and verb forms used by the candidates and relates them to the GCSE vocabulary and structure lists. Chapter 5 analyses errors with particular reference to the influence of Panjabi and the relationship between phonemes and graphemes and considers them from the standpoint of the GCSE assessment criteria. Chapter 6 contains an analysis of English words used in the Urdu compositions and of those included in the GCSE vocabularies. The final chapter summarises the findings of the research and suggests areas worthy of further investigation. Alternative examination formats are also suggested which may be more appropriate for Urdu than those prescribed. These include graded assessment, the introduction of national attainment targets and the development of a new post 16+ examination.
sj-pdf-6-ajr-10.1177_1945892420932487 - Supplemental material for Effect of Exposure to Cats and Dogs on the Risk of Asthma and Allergic Rhinitis: A Systematic Review and Meta-analysis
Creators: name: Gao, Xiaoping
name: Yin, Mei
name: Yang, Pei
name: Li, Xia
name: Di, Lingling
name: Wang, Wei
name: Cui, Hua
name: Yan, Xiaohui
name: Liu, Jing
Publisher: name: SAGE Journals
Year: 2020
Subjects: Otorhinolaryngology

description: Supplemental material, sj-pdf-6-ajr-10.1177_1945892420932487 for Effect of Exposure to Cats and Dogs on the Risk of Asthma and Allergic Rhinitis: A Systematic Review and Meta-analysis by Xiaoping Gao, Mei Yin, Pei Yang, Xia Li, Lingling Di, Wei Wang, Hua Cui, Xiaohui Yan and Jing Liu in American Journal of Rhinology & Allergy