cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
News media consumption and support for counter-terrorism measures: the role of hatred and fear
Creators: name: Arnoso-Martínez, Maitane
name: Bobowik, Magdalena
name: González-Ortega, Nerea
name: Martinović, Borja
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Media are a key social agent shaping society’s responses to measures implemented in the fight against terrorism. We argue that emotions elicited by media narratives on terrorist attacks are decisive to understand the link between the news media consumption and citizens’ support for military intervention in the Middle East, as well as for security measures in the home country. In two studies conducted after the Brussels attacks (N = 250) and the Barcelona attacks (N = 633), we tested the explanatory role of emotions – specifically fear and hatred – in the association between media narratives and these two outcomes. The results of both studies show that hatred explained the positive relationship between news media consumption and support for military intervention, and to a lesser degree, agreement with security measures. In contrast, the positive relationship between news media consumption and agreement with security measures was explained by fear. This research underscores the need to consider how emotions are utilized in media discourse. We discuss practical implications of our findings for promoting ethical journalism.
Fusing ToF-SIMS images for spatial-spectral resolution enhancement using a convolutional neural network
Creators: name: Gardner, Wil
name: Winkler, David
name: Maliki, Ruqaya
name: Cutts, Suzanne
name: Ellis, Sarah
name: Anderson, Robin
name: Muir, Benjamin
name: Pigram, Paul
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 340199
subject: Analytical chemistry not elsewhere classified
classificationCode: 340699
subject: Physical chemistry not elsewhere classified

description: Hyperspectral data sets generated by time-of-flight secondary ion mass spectrometry (ToF-SIMS) contain valuable spatial-spectral information characterizing the distribution of atomic and molecular species across a sample surface. Modern ToF-SIMS instruments have high spatial resolution (in the order of tens of nanometers) relative to most other mass spectrometry imaging (MSI) techniques. However, there is generally a trade-off between spatial and mass resolution when using different instrument modes. In this study, a convolutional neural network (CNN) fusion method is used to fuse correlated high spatial and high mass resolution ToF-SIMS hyperspectral data sets. This process generates resolution-enhanced data, which exhibit both high spatial and mass resolution. The CNN fusion method is applied to ToF-SIMS images of a simple, well-characterized gold mesh sample and a significantly more complex biological (tumor) tissue section. The method is compared to another linear fusion method used in the broader MSI community and a substantial improvement is found. This comparison focuses on both visual quality observations as well as statistical similarity measures. This work demonstrates the utility of the CNN fusion method for ToF-SIMS data, enabling investigation of the atomic and molecular characteristics of surfaces at high spatial and mass spectral resolution.
Secondary Omental Infarction
Creators: name: Eiroa GutiÃ©Rrez, Daniel
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Abdomen
subject: CT
subject: Diagnostic procedure
subject: Acute

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 77 years
description: Clinical History: 77 year-old patient who had undergone a right hemicolectomy less than a month before presents in the emergency room with right lower quadrant and middle lower quadrant pain and tenderness. No fever was reported. Lab tests showed mild leukocytosis and anae... Final Diagnosis: Omental Infarction
Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons
Creators: name: Widagdo, J
name: Udagedara, Saumya
name: Bhembre, N
name: Tan, JZA
name: Neureiter, L
name: Huang, J
name: Anggono, V
name: Lee, Mihwa
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). We have previously reported that zinc mediates SFPQ polymerization and promotes the formation of cytoplasmic aggregates in neurons. Here we characterize two familial ALS (fALS)-associated SFPQ variants, which cause amino acid substitutions in the proximity of the SFPQ zinc-coordinating centre (N533H and L534I). Both mutants display increased zinc-binding affinities, which can be explained by the presence of a second zinc-binding site revealed by the 1.83 Å crystal structure of the human SFPQ L534I mutant. Overexpression of these fALS-associated mutants significantly increases the number of SFPQ cytoplasmic aggregates in primary neurons. Although they do not affect the density of dendritic spines, the presence of SFPQ cytoplasmic aggregates causes a marked reduction in the levels of the GluA1, but not the GluA2 subunit of AMPA-type glutamate receptors on the neuronal surface. Taken together, our data demonstrate that fALS-associated mutations enhance the propensity of SFPQ to bind zinc and form aggregates, leading to the dysregulation of AMPA receptor subunit composition, which may contribute to neuronal dysfunction in ALS.
Sigmoid Colon Endometriosis: Mimicking Sigmoid Colon Carcinoma with Extra-serosal Involvement
Creators: name: Salahudeen, Hajamohideen
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Abdomen
subject: CT
subject: Diagnostic procedure
subject: Inflammation

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 48 years
description: Clinical History: A 48-year-old female, with a history of haemorrhoidal disease, presented to our institution with haematochezia and increased bowel frequency for the past 3 months. Digital rectal examination revealed non-bleeding, non-prolapsed internal haemorrhoids. Colo... Final Diagnosis: Endometriosis of the sigmoid colon
Homologous peptides derived from influenza A, B and C viruses induce variable CD8(+) T cell responses with cross-reactive potential
Creators: name: Nguyen, Andrea
name: Lau, Hiu Ming Peter
name: Sloane, Hannah
name: Jayasinghe, Dhilshan
name: Mifsud, Nicole A
name: Chatzileontiadou, Dimitra
name: Grant, Emma
name: Szeto, Christopher
name: Gras, Stephanie
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 320499
subject: Immunology not elsewhere classified
classificationCode: 320799
subject: Medical microbiology not elsewhere classified

description: Objective: Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally, infecting humans and causing widespread morbidity and mortality. Here, we investigate the T cell response towards an immunodominant IAV epitope, NP265-273, and its IBV and ICV homologues, presented by HLA-A*03:01 molecule expressed in ~ 4% of the global population (~ 300 million people). Methods: We assessed the magnitude (tetramer staining) and quality of the CD8+ T cell response (intracellular cytokine staining) towards NP265-IAV and described the T cell receptor (TCR) repertoire used to recognise this immunodominant epitope. We next assessed the immunogenicity of NP265-IAV homologue peptides from IBV and ICV and the ability of CD8+ T cells to cross-react towards these homologous peptides. Furthermore, we determined the structures of NP265-IAV and NP323-IBV peptides in complex with HLA-A*03:01 by X-ray crystallography. Results: Our study provides a detailed characterisation of the CD8+ T cell response towards NP265-IAV and its IBV and ICV homologues. The data revealed a diverse repertoire for NP265-IAV that is associated with superior anti-viral protection. Evidence of cross-reactivity between the three different influenza virus strain-derived epitopes was observed, indicating the discovery of a potential vaccination target that is broad enough to cover all three influenza strains. Conclusion: We show that while there is a potential to cross-protect against distinct influenza virus lineages, the T cell response was stronger against the IAV peptide than IBV or ICV, which is an important consideration when choosing targets for future vaccine design.
The anti-inflammatory effects of vitamin B6 on neuroinflammation and neuronal damage caused by 1,2-diacetylbenzene in BV2 microglial and sH-SY5Y cells
Creators: name: Nguyen, Hai Duc
name: Jo, Won Hee
name: Hoang, Ngoc Hong Minh
name: Kim, Min‐Sun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The pathophysiology of cognitive impairment has recently focused on 1,2-Diacetylbenzene (DAB), B vitamins, tau hyperphosphorylation, and neuroinflammation. While past evidence shows that vitamin B6 influences the immune system, the molecular processes behind DAB-induced neuroinflammation and cognitive impairment remain largely unknown. This study aimed to assess the protective roles of vitamin B6 against DAB-induced toxicity in BV2 microglial and SH-SY5Y cells. In vitro approaches included Western blot, qRT-PCR, cell viability assays, immunocytochemistry, reactive oxygen species, and nitrite assays. For in silico analysis, we utilized Metascape, Cytoscape, MIENTURNET, and molecular docking. Vitamin B6 suppressed the TLR4/NF-κB pathway and the TREM-1/DAP12/NLRP3/caspase-1/IL1B pathway in DAB-activated BV2 cells. Additionally, it reduced reactive oxygen species and nitric oxide levels while increasing Nrf2 and IL10 production. In SH-SY5Y cells, vitamin B6 inhibited GSK-3β Tyr216, tau hyperphosphorylation, and β-amyloid production. The in silico analysis identified ‘positive regulation of NF-κB transcription factor activity,’ ‘regulation of IL-6 production,’ and ‘positive regulation of adaptive immune response’ as key molecular mechanisms linked with DAB-induced cognitive impairment and targeted by vitamin B6. Core genes, miRNAs, and transcription factors included IL1β, IL6, IL10, TNF, hsa-miR-155-5p, hsa-miR-203a-3p, hsa-miR-106a-5p, hsa-miR-26a-5p, CEBPB, and PXR. Our findings indicate that vitamin B6 may protect against DAB-induced cognitive impairment by attenuating key inflammatory pathways, reducing oxidative stress, and inhibiting tau hyperphosphorylation, β-amyloid production, and GSK-3β Tyr216 phosphorylation. This highlights its potential as a therapeutic agent for cognitive impairment. B6 inhibited the DAB-induced TREM-1/DAP12/NLRP3/caspase-1/IL1B pathwayB6 suppressed the DAB-induced and the TLR4/NF-κB pathwayB6 inhibited ROS, NO, and activated Nrf2 and IL-10 expressionB6 attenuated DAB-caused GSK-3β, β-amyloid, and tau hyperphosphorylationIn-silico analysis found B6 involved in cognitive impairment etiology caused by DAB B6 inhibited the DAB-induced TREM-1/DAP12/NLRP3/caspase-1/IL1B pathway B6 suppressed the DAB-induced and the TLR4/NF-κB pathway B6 inhibited ROS, NO, and activated Nrf2 and IL-10 expression B6 attenuated DAB-caused GSK-3β, β-amyloid, and tau hyperphosphorylation In-silico analysis found B6 involved in cognitive impairment etiology caused by DAB
Additional file 1 of Factors associated with anemia among children in South and Southeast Asia: a multilevel analysis
Creators: name: Sunuwar, Dev Ram
name: Singh, Devendra Raj
name: Pradhan, Pranil Man Singh
name: Shrestha, Vintuna
name: Rai, Pushpa
name: Shah, Sunil Kumar
name: Adhikari, Bipin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary Material 1
Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways
Creators: name: Abdelaala, Nashwa
name: El-Shoura, Ehab A. M.
name: Khalaf, Marwa M.
name: Zafaar, Dalia
name: Ahmed, Ahmed A. N.
name: Atwa, Ahmed M.
name: Abdel-Wahab, Basel A.
name: Ahmed, Yasmine H.
name: Abomandour, Ahmed
name: Salem, Esraa A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Hematology

description: Amikacin (AMC), an aminoglycoside antibiotic known for its rapid and potent bactericidal activity, is also associated with nephrotoxicity. Diosmin and perindopril have been reported to improve renal function and hold promise as therapeutic agents for preventing drug-induced nephrotoxicity. This study aimed to investigate the protective effect of Diosmin and perindopril, either alone or in combination, against renal damage induced by AMC toxicity and to elucidate the underlying mechanisms. The researchers evaluated the impact of Diosmin (50 mg/kg, orally) and perindopril (2 mg/kg, intraperitoneally) on AMC-induced kidney injury (1.2 g/kg, intraperitoneally) in rats. Invasive blood pressure, serum kidney function and toxicity parameters, oxidative stress biomarkers, and inflammatory cytokine levels in serum and renal tissue were assessed. Histopathological changes in the kidney were examined using hematoxylin and eosin (H&E) staining, electron microscopy, and immunohistochemical analysis. The molecular mechanisms underlying the protective effect of the combination pretreatment on kidney injury were investigated using enzyme-linked immunosorbent assay (ELISA) and Western blotting techniques. The findings demonstrated that the combination therapy improved kidney function by attenuating pathological changes observed in H&E staining including tubular necrosis and glomerular damage, in addition to reducing levels of kidney function including serum levels of creatinine compared to the AMC group, blood urea nitrogen (BUN) uric acid, and albumin. Mean arterial blood pressure, and toxicity markers including Kidney Injury Molecule-1 (KIM-1), Cystatin-c were also decreased in samples of combination group compared to AMC group. Furthermore, the protective combination therapy downregulated NF-κB-p65, P53, Keap-1, and C-FOS, while upregulating Mammalian sirtuin 1 (SIRT1), inhibitor of nuclear factor kappa B (Iκβ), nuclear factor erythroid 2–related factor 2 (Nrf2), and Heme oxygenase-1 (HO-1) levels. The findings reveal the potential clinical application of combining Diosmin and perindopril to reduce AMC-induced nephrotoxicity, which requires further research in clinical settings.
Giant cavernous hemangioma with âflame-shapedâ enhancement in female patient
Creators: name: Petrenko, Dmytro
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Liver
subject: CT
subject: MR
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Haemangioma

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 46 years
description: Clinical History: Female patient 46 y.o. has arrived to emergency department with complaints of abdominal pain in right upper quadrant and abdominal distension. Laboratory tests were normal except PCR of 8.1. After hospitalization both MDCT and MRI have been performed. Final Diagnosis: Giant cavernous hemangioma
Therapeutic effect of nintedanib in orbital fibroblasts in patients with Graves’ orbitopathy
Creators: name: Park, Hyun Young
name: Choi, Soo Hyun
name: Ko, JaeSang
name: Yoon, Jin Sook
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Nintedanib is a potent antifibrotic angiokinase inhibitor approved for various fibrotic lung diseases. Potential therapeutic efficacy of nintedanib in various inflammatory diseases is under investigation. In this study, we investigated the therapeutic effect of nintedanib on adipogenesis and fibrosis in orbital fibroblasts in patients with Graves’ orbitopathy (GO). Primary orbital fibroblasts were cultured from orbital connective tissue of patients with GO and healthy controls. The cells were pretreated with nintedanib before stimulation with either interleukin (IL)-1β, transforming growth factor (TGF)-β, insulin-like growth factor-1, or IL-11. Fibrosis-related and intracellular signaling protein expressions were assessed using western blotting. Hyaluronan and procollagen concentrations were quantified using enzyme-linked immunosorbent assay. Adipogenesis was quantified by Oil Red O staining and the levels of adipogenic transcription factors were determined by Western blot. TGF-β-induced fibronectin and collagen 1/3 protein expression was abrogated by nintedanib treatment. Nintedanib decreased the phosphorylation of signal transducer and activator of transcription 3, SMAD 2/3, Akt, c-Jun N-terminal kinase, and extracellular regulated protein kinase. Exposure to nintedanib hindered adipocyte differentiation and expression of adipogenic transcription factors, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein α/β, adipocyte protein 2, adiponectin, and leptin. Additionally, nintedanib reduced hyaluronan and procollagen secretion. Nintedanib suppressed profibrotic protein production, adipogenesis, and hyaluronan production in in vitro. These findings indicate the potential therapeutic efficacy of nintedanib in GO management.
SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER) versus minimal intervention for young adults at risk of knee osteoarthritis after ACL reconstruction: SUPER-Knee randomised controlled trial protocol
Creators: name: Culvenor, Adam
name: West, Thomas
name: Bruder, Andrea
name: Scholes, Mark
name: Barton, Christian
name: Roos, Ewa
name: Oei, E
name: McPhail, SM
name: Souza, RB
name: Lee, J
name: Patterson, Brooke
name: Girdwood, Michael
name: Couch, Jamon
name: Crossley, Kay
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified
classificationCode: 420109
subject: Rehabilitation

description: Introduction Anterior cruciate ligament injury and reconstruction (ACLR) is often associated with pain, functional loss, poor quality of life and accelerated knee osteoarthritis development. The effectiveness of interventions to enhance outcomes for those at high risk of early-onset osteoarthritis is unknown. This study will investigate if SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER) is superior to a minimal intervention control for improving pain, function and quality of life in young adults with ongoing symptoms following ACLR. Methods and analysis The SUPER-Knee Study is a parallel-group, assessor-blinded, randomised controlled trial. Following baseline assessment, 184 participants aged 18-40 years and 9-36 months post-ACLR with ongoing symptoms will be randomly allocated to one of two treatment groups (1:1 ratio). Ongoing symptoms will be defined as a mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score (KOOS 4) subscales covering pain, symptoms, function in sports and recreational activities and knee-related quality of life. Participants randomised to SUPER will receive a 4-month individualised, physiotherapist-supervised strengthening and neuromuscular programme with education. Participants randomised to minimal intervention (ie, control group) will receive a printed best-practice guide for completing neuromuscular and strengthening exercises following ACLR. The primary outcome will be change in the KOOS 4 from baseline to 4 months with a secondary endpoint at 12 months. Secondary outcomes include change in individual KOOS subscale scores, patient-perceived improvement, health-related quality of life, kinesiophobia, physical activity, thigh muscle strength, knee function and knee cartilage morphology (ie, lesions, thickness) and composition (T2 mapping) on MRI. Blinded intention-to-treat analyses will be performed. Findings will also inform cost-effectiveness analyses. Ethics and dissemination This study is approved by the La Trobe University and Alfred Hospital Ethics Committees. Results will be presented in peer-reviewed journals and at international conferences. Trial registration number ACTRN12620001164987.
Mineral Healing: Gemstone Remedies in Astrological and Medical Traditions
Creators: name: Cerulli, Anthony
name: Guenzi, Caterina
Publisher: name: Equinox Publishing, Ltd.
Year: 2016
Subjects: subject: Indian literature
subject: Sanskrit literature
subject: India

description: A philological and ethnographic study of medical and astrological positions on gemstones in Sanskrit literature and contemporary North Indian society.
Additional file 1 of The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Creators: name: Morena da Silva, Francielly
name: Lim, Seongkyun
name: Cabrera, Ana Regina
name: Schrems, Eleanor R.
name: Jones, Ronald G.
name: Rosa-Caldwell, Megan E.
name: Washington, Tyrone A.
name: Murach, Kevin A.
name: Greene, Nicholas P.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Top unique to female dysregulated pathways (a), Top unique to maledysregulated pathways (b). Top 20 of each Kegg, Reactome, and WikiPathways.Adjusted P-value<0.05.
Supplemental Material, Zunmin_Wu_(Appendix) - China’s Experiences in Developing Lifelong Education, 1978–2017
Creators: name: Wu, Zunmin
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education

description: Supplemental Material, Zunmin_Wu_(Appendix) for China’s Experiences in Developing Lifelong Education, 1978–2017 by Zunmin Wu in ECNU Review of Education
Unveiling the potential of PVDF@LaFeO3 based flexible composite films towards high performance broad band EMI shielding
Creators: name: Mamatha, G. M.
name: Dixit, Pradipkumar
name: Krishna, R. Hari
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Information Systems not elsewhere classified
subject: Cancer

description: The present study deals with development of optimized polyvinylidene difluoride (PVDF)-based flexible composite thin film with magnetic filler (LaFeO3) and conductive fillers-graphene and multi-walled carbon nanotubes (MWCNT). The performance of developed PVDF-based composite films has been tested for EMI SE over a wide band ranging from 8.2 to 12.4 GHz and 12.4 to 18 GHz covering X and Ku band. The work has been carried out using experimental setup based on ASTM D5568 standard for EMI SE measurements and the investigation has been extended to validate EMI performance of the developed lightweight, flexible, thin polymer composite films using finite element analysis (FEA) simulation software ANSYS HFSS. In both experimental and simulation results, a film composed of 5 wt.% of LaFeO3, 5 wt.% MWCNT and 25 wt.% of graphene unveiled a better EMI SE compared to bare PVDF and films with only conducting graphene.
A Buried Water Network Modulates the Activity of the Escherichia coli Disulphide Catalyst DsbA
Creators: name: Wang, Geqing
name: Qin, J
name: Verderosa, AD
name: Hor, Lilian
name: Santos Martin, Carlos Fernando
name: Paxman, Jason
name: Martin, JL
name: Totsika, M
name: Heras, Begona
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: The formation of disulphide bonds is an essential step in the folding of many proteins that enter the secretory pathway; therefore, it is not surprising that eukaryotic and prokaryotic organisms have dedicated enzymatic systems to catalyse this process. In bacteria, one such enzyme is disulphide bond-forming protein A (DsbA), a thioredoxin-like thiol oxidase that catalyses the oxidative folding of proteins required for virulence and fitness. A large body of work on DsbA proteins, particularly Escherichia coli DsbA (EcDsbA), has demonstrated the key role that the Cys30-XX-Cys33 catalytic motif and its unique redox properties play in the thiol oxidase activity of this enzyme. Using mutational and functional analyses, here we identify that a set of charged residues, which form an acidic groove on the non-catalytic face of the enzyme, further modulate the activity of EcDsbA. Our high-resolution structures indicate that these residues form a water-mediated proton wire that can transfer protons from the bulk solvent to the active site. Our results support the view that proton shuffling may facilitate the stabilisation of the buried Cys33 thiolate formed during the redox reaction and promote the correct direction of the EcDsbA–substrate thiol–disulphide exchange. Comparison with other proteins of the same class and proteins of the thioredoxin-superfamily in general suggest that a proton relay system appears to be a conserved catalytic feature among this widespread superfamily of proteins. Furthermore, this study also indicates that the acidic groove of DsbA could be a promising allosteric site to develop novel DsbA inhibitors as antibacterial therapeutics.
The Symbolic Meaning of Water in 'A Room with a View' by E. M. Forster
Creators: name: Fordonski, Krzysztof
Publisher: name: Universitas
Year: 1999
Subjects: subject: English literature

description: The article presents a detailed analysis of the variety of uses of water symbolism in E. M. Forster's novel 'A Room with a View'
Bela, Teresa and Zbigniew Mazur eds. Tradition and Postmodernity. English and American Studies and the Challenge of the Future. Kraków: Universitas, 1999 pp. 203-212.This is an early version based on conference paper
Additional file 1 of Recurrence intervals for M > 7 Miyagi-ken-Oki earthquakes during an M ~ 9 earthquake cycle
Creators: name: Nakata, Ryoko
name: Uchida, Naoki
name: Hori, Takane
name: Hino, Ryota
Publisher: name: figshare
Year: 2024
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences

description: Additional file 1. 1.1-1.3. Detailed discription of Methods. Table S1. Parameters used in this study. Figure S1. Schematic illustration of the definition of subfaults.
Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth
Creators: name: Poh, Qi Hui
name: Rai, Alin
name: Pangestu, Mulyoto
name: Salamonsen, Lois A
name: Greening, David
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3101
subject: Biochemistry and cell biology

description: Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth critical for successful implantation. While EVs have garnered immense interest in their therapeutic potential in assisted reproductive technology by improving implantation success, their large-scale generation remains a major challenge. Here, we report a rapid and scalable production of nanovesicles (NVs) directly from human trophectoderm cells (hTSCs) via serial mechanical extrusion of cells; these NVs can be generated in approximately 6 h with a 20-fold higher yield than EVs isolated from culture medium of the same number of cells. NVs display similar biophysical traits (morphologically intact, spherical, 90–130 nm) to EVs, and are laden with hallmark players of implantation that include cell-matrix adhesion and extracellular matrix organisation proteins (ITGA2/V, ITGB1, MFGE8) and antioxidative regulators (PRDX1, SOD2). Functionally, NVs are readily taken up by low-receptive endometrial HEC1A cells and reprogram their proteome towards a receptive phenotype that support hTSC spheroid attachment. Moreover, a single dose treatment with NVs significantly enhanced adhesion and spreading of mouse embryo trophoblast on fibronectin matrix. Thus, we demonstrate the functional potential of NVs in enhancing embryo implantation and highlight their rapid and scalable generation, amenable to clinical utility.
Development and fabrication of a novel nano-bilosomal system for enhanced oral delivery of Trametinib: apoptotic induction and anticancer efficacy evaluation
Creators: name: Chettupalli, Ananda Kumar
name: Chokkarapu, Suryanarayana
name: Singh, Ankit
name: Babu, Molakpogu Ravindra
name: Singh, Mukul Pratap
name: Bukke, Sarad Pawar Naik
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: In order to inhibit growth factor-mediated cell signalling and cell proliferation in various cancers, Trametinib (TM) binds preferentially to Mitogen-Activated Protein Kinase Kinase 1 and 2 (MEK). This study marks a first impression in assessing the impact of bilosomes (BS) of TM on oral bioavailability. A thin-film hydration technique, and the optimisation was done using Box-Behnken Design. Quantities of sodium taurocholate (STC), cremophor EL and Span 60 were taken as independent variables. The optimized formulation depicted a low hydrodynamic diameter (158.32±10.24nm) and high entrapment efficiency (94.27±2.16%), zetapotential (-46.57±1.06 mV) and PDI (0.132±0.03). The TM-BS showed a biphasic release pattern and obtained significantly high penetration compared to the pure TM solution (p<.05). The modified formulation, which is an optimised TM-BS, demonstrated lower IC50 in comparison to A549 cells, according to the cytotoxic evaluation. Additionally, enhanced TM-BS dramatically raised cellular caspase-3 protein expression. The TM-BS killed A549 cells better than TM solution.
Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.
Creators: name: Cross, Jonathon
name: Rai, Alin
name: Fang, Haoyun
name: Claridge, Bethany
name: Greening, David
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 310109
subject: Proteomics and intermolecular interactions (excl. medical proteomics)

description: The integration of robust single-pot, solid-phase-enhanced sample preparation with powerful liquid chromatography-tandem mass spectrometry (LC-MS/MS) is routinely used to define the extracellular vesicle (EV) proteome landscape and underlying biology. However, EV proteome studies are often limited by sample availability, requiring upscaling cell cultures or larger volumes of biofluids to generate sufficient materials. Here, we have refined data independent acquisition (DIA)-based MS analysis of EV proteome by optimizing both protein enzymatic digestion and chromatography gradient length (ranging from 15 to 44 min). Our short 15 min gradient length can reproducibly quantify 1168 (from as little as 500 pg of EV peptides) to 3882 proteins groups (from 50 ng peptides), including robust quantification of 22 core EV marker proteins. Compared to data-dependent acquisition, DIA achieved significantly greater EV proteome coverage and quantification of low abundant protein species. Moreover, we have achieved optimal magnetic bead-based sample preparation tailored to low quantities of EVs (0.5 to 1 µg protein) to obtain sufficient peptides for MS quantification of 1908–2340 protein groups. We demonstrate the power and robustness of our pipeline in obtaining sufficient EV proteomes granularity of different cell sources to ascertain known EV biology. This underscores the capacity of our optimised workflow to capture precise and comprehensive proteome of EVs, especially from ultra-low sample quantities (sub-nanogram), an important challenge in the field where obtaining in-depth proteome information is essential.
Supplemental_Material – Supplemental material for Managerial Judgment In City Benchmarking
Creators: name: Zekan, Bozana
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental material, Supplemental_Material for Managerial Judgment In City Benchmarking by Bozana Zekan in Journal of Hospitality & Tourism Research
The EU Open Research Repository on Zenodo – supporting the implementation of the EU open science policy
Creators: name: Nielsen, Lars Holm
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Zenodo
subject: Policy
subject: Data Management
subject: Policy implementation
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: The EU Open Research Repository, launched on Zenodo in 2024, operationalises the EU Open Science policy by providing a research repository tailored for EU research funding beneficiaries. This presentation outlines its innovative data-curation framework, featuring AI-driven tools and high-quality open datasets that reduce the cost and effort of curation. It emphasises the repository’s adherence to FAIR (findable, accessible, interoperable and reusable) data principles through automated checks and guidance. Integration with data.europa.eu enhances repository optimisation and data quality.

Recording available on YouTube
Sourous, Apa Sourous, superior and holy man at the monastery of Apa Phoibammon on the mountain of Jeme
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Sourous, Apa Sourous, superior and holy man at the monastery of Apa Phoibammon on the mountain of Jeme.
Additional file 1 of Examining the replicability of backfire effects after standalone corrections
Creators: name: Prike, Toby
name: Blackley, Phoebe
name: Swire-Thompson, Briony
name: Ecker, Ullrich K. H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Additional file 1. Supplementary materials containing pilot study results, additional analyses, and study materials.
Additional file 1 of Hunting practices in southwestern Amazonia: a comparative study of techniques, modalities, and baits among urban and rural hunters
Creators: name: Oliveira, Marcela Alvares
name: Braga-Pereira, Franciany
name: El Bizri, Hani Rocha
name: Morcatty, Thais Queiroz
name: Doria, Carolina Rodrigues da Costa
name: Messias, Mariluce Rezende
Publisher: name: figshare
Year: 2024
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Details of the full models and the null model using a generalized linear model to check the relationship of hunting motivations in urban and rural huntersand personal variables in urban and rural hunters.
sj-pdf-1-jhs-10.1177_1753193420965393 - Supplemental material for Patient-reported outcomes after digit replantation and revision amputation: when is maximum recovery attained?
Creators: name: Yoon, Alfred P.
name: Wang, Yibo
name: Wang, Lu
name: Chung, Kevin C.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Orthopaedics
Sports Medicine
Surgery

description: Supplemental material, sj-pdf-1-jhs-10.1177_1753193420965393 for Patient-reported outcomes after digit replantation and revision amputation: when is maximum recovery attained? by Alfred P. Yoon, Yibo Wang, Lu Wang, Kevin C. Chung and for The FRANCHISE Group in Journal of Hand Surgery (European Volume)
HB-EGF-loaded nanovesicles enhance trophectodermal spheroid attachment and invasion.
Creators: name: Poh, Qi Hui
name: Rai, Alin
name: Cross, Jonathon
name: Greening, David
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3215
subject: Reproductive medicine
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3205
subject: Medical biochemistry and metabolomics

description: The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial cells and subsequently invade the underlying matrix are critical stages of embryo implantation during successful pregnancy establishment. Extracellular vesicles (EVs) have been implicated in embryo-maternal crosstalk, capable of reprogramming endometrial cells towards a pro-implantation signature and phenotype. However, challenges associated with EV yield and direct loading of biomolecules limit their therapeutic potential. We have previously established generation of cell-derived nanovesicles (NVs) from human trophectodermal cells (hTSCs) and their capacity to reprogram endometrial cells to enhance adhesion and blastocyst outgrowth. Here, we employed a rapid NV loading strategy to encapsulate potent implantation molecules such as HB-EGF (NVHBEGF). We show these loaded NVs elicit EGFR-mediated effects in recipient endometrial cells, activating kinase phosphorylation sites that modulate their activity (AKT S124/129, MAPK1 T185/Y187), and downstream signalling pathways and processes (AKT signal transduction, GTPase activity). Importantly, they enhanced target cell attachment and invasion. The phosphoproteomics and proteomics approach highlight NVHBEGF-mediated short-term signalling patterns and long-term reprogramming capabilities on endometrial cells which functionally enhance trophectodermal-endometrial interactions. This proof-of-concept study demonstrates feasibility in enhancing the functional potency of NVs in the context of embryo implantation.
Yawnan/Jonah and Brikhišo‘/Barachisios, brothers and martyrs in Persia under Shapur II, with nine companions
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Yawnan/Jonah and Brikhišo‘/Barachisios, brothers and martyrs in Persia under Shapur II, with nine companions.
Transcriptomic analysis and fusion gene identifications of midbody remnants released from colorectal cancer cells reveals they are molecularly distinct from exosomes and microparticles
Creators: name: Suwakulsiri, Wittaya
name: Xu, Rong
name: Rai, Alin
name: Chen, Maoshan
name: Shafiq, Adnan
name: Greening, David
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3101
subject: Biochemistry and cell biology

description: Abstract: Previously, we reported that human primary (SW480) and metastatic (SW620) colorectal (CRC) cells release three classes of membrane-encapsulated extracellular vesicles (EVs); midbody remnants (MBRs), exosomes (Exos), and microparticles (MPs). We reported that MBRs were molecularly distinct at the protein level. To gain further biochemical insights into MBRs, Exos, and MPs and their emerging role in CRC, we performed, and report here, for the first time, a comprehensive transcriptome and long noncoding RNA sequencing analysis and fusion gene identification of these three EV classes using the next-generation RNA sequencing technique. Differential transcript expression analysis revealed that MBRs have a distinct transcriptomic profile compared to Exos and MPs with a high enrichment of mitochondrial transcripts lncRNA/pseudogene transcripts that are predicted to bind to ribonucleoprotein complexes, spliceosome, and RNA/stress granule proteins. A salient finding from this study is a high enrichment of several fusion genes in MBRs compared to Exos, MPs, and cell lysates from their parental cells such as MSH2 (gene encoded DNA mismatch repair protein MSH2). This suggests potential EV-liquid biopsy targets for cancer detection. Importantly, the expression of cancer progression-related transcripts found in EV classes derived from SW480 (EGFR) and SW620 (MET and MACCA1) cell lines reflects their parental cell types. Our study is the report of RNA and fusion gene compositions within MBRs (including Exos and MPs) that could have an impact on EV functionality in cancer progression and detection using EV-based RNA/ fusion gene candidates for cancer biomarkers.
Use of pharmacokinetic versus pharmacodynamic endpoints to support human dose predictions: implications for rational drug design and early clinical development
Creators: name: Li, Rui
name: Maurer, Tristan S.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The predicted human dose regimen of new chemical entities represents the most holistic and clinically relevant measure of drug-likeness upon which to base decisions in drug design and selection of candidate molecules for further development. Likewise, the predicted human dose regimen for efficacy and safety provides critical insight into clinical development planning. As such, human dose predictions are commonly generated in early stages of research and continually revisited as new data are generated through development. In this work, the authors illustrate scenarios where conventional approaches based on discrete pharmacokinetic metrics are inappropriate and propose a generalizable approach leveraging a predicted average pharmacodynamic effect rather than pharmacokinetic metrics. Preclinical and clinical data of a JAK inhibitor, tofacitinib, were used to illustrate the relative value of this approach to human dose prediction. Due to the simplicity of implementation, pharmacokinetic-based approaches which target a discrete maximal, average, or minimum concentration have been widely used across the pharmaceutical industry. However, in emphasizing only one point on the overall exposure-time profile, such approaches can be misleading in terms of the expected pharmacodynamic effect. For future projections, the authors recommend using the average pharmacodynamic effect-based approach to calculate human efficacious dose.
'Mingled Yarn': The State of Computing in Shakespeare 2.0
Creators: name: Craig, Hugh
name: Greatley-Hirsch, Brett
Publisher: name: unknown
Year: 2014
Subjects: subject: Shakespeare, William, 1564-1616
subject: Digital humanities

description: Brett D. Hirsch and Hugh Craig, " 'Mingled Yarn': The State of Computing in Shakespeare 2.0." Digital Shakespeares: Innovations, Interventions, Mediations, ed. Brett D. Hirsch and Hugh Craig. Special issue of The Shakespearean International Yearbook 14 (2014): 3-35.
description: Brett D. Hirsch and Hugh Craig, " 'Mingled Yarn': The State of Computing in Shakespeare 2.0." Digital Shakespeares: Innovations, Interventions, Mediations, ed. Brett D. Hirsch and Hugh Craig. Special issue of The Shakespearean International Yearbook 14 (2014): 3-35.
title: 'What are these faces?' Interpreting Bearded Women in Macbeth
title: 'What are these faces?' Interpreting Bearded Women in Macbeth
titleType: Other
Creators: name: Greatley-Hirsch, Brett
Publisher: name: Cambridge Scholars Press
Year: 2008
Subjects: subject: Shakespeare, William, 1564-1616

description: Brett D. Hirsch, " 'What are these faces?' Interpreting Bearded Women in Macbeth." Renaissance Drama and Poetry in Context: Essays for Christopher Wortham. Ed. Andrew Lynch and Anne M. Scott. Newcastle-upon-Tyne: Cambridge Scholars Press, 2008. 91-114.
description: Brett D. Hirsch, " 'What are these faces?' Interpreting Bearded Women in Macbeth." Renaissance Drama and Poetry in Context: Essays for Christopher Wortham. Ed. Andrew Lynch and Anne M. Scott. Newcastle-upon-Tyne: Cambridge Scholars Press, 2008. 91-114.
Rupture of an echinococcal cyst within the colon in a case of disseminated abdominal cystic echinococcosis
Creators: name: Giarraputo, Leonardo
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Abdomen
subject: Education
subject: CT
subject: Ultrasound
subject: Diagnostic procedure
subject: Education
subject: Parasites

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 25 years
description: Clinical History: A young woman from Eastern Europe presented to the emergency room for an acute abdominal pain at the left flank. Routine blood tests showed elevation of white cell blood count (18.3x109/L) and increase of serum C-reactive protein (4.53 mg/dL, u... Final Diagnosis: Disseminated abdominal cystic echinococcosis with cyst-colon rupture
title: Lycanthropy in Early Modern England: The Case of John Webster's The Duchess of Malfi
title: Lycanthropy in Early Modern England: The Case of John Webster's The Duchess of Malfi
titleType: Other
Creators: name: Greatley-Hirsch, Brett
Publisher: name: Brepols
Year: 2011

description: Brett D. Hirsch, "Lycanthropy in Early Modern England: The Case of John Webster's The Duchess of Malfi." Diseases of the Imagination and Imaginary Disease in the Early Modern Period. Ed. Yasmin Haskell. Turnhout: Brepols, 2011. 297-337.
description: Brett D. Hirsch, "Lycanthropy in Early Modern England: The Case of John Webster's The Duchess of Malfi." Diseases of the Imagination and Imaginary Disease in the Early Modern Period. Ed. Yasmin Haskell. Turnhout: Brepols, 2011. 297-337.