cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis
Creators: name: Schlicker, Andreas
name: Ellappalayam, Architha
name: Beumer, Ines J.
name: Snel, Mireille H. J.
name: Mittempergher, Lorenza
name: Diosdado, Begona
name: Dreezen, Christa
name: Tian, Sun
name: Salazar, Ramon
name: Loupakis, Fotios
name: Pietrantonio, Filippo
name: Santos Vivas, Cristina
name: Martinez‐Villacampa, Maria Mercedes
name: Villanueva, Alberto
name: Sanjuán, Xavier
name: Schirripa, Marta
name: Fassan, Matteo
name: Martinetti, Antonia
name: Fucà, Giovanni
name: Lonardi, Sara
name: Keilholz, Ulrich
name: Glas, Annuska M.
name: Bernards, René
name: Vecchione, Loredana
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: colorectal cancer molecular classification
subject: gene expression profile of primary and synchronous liver metastasis
subject: molecular concordance between primary and liver metastasis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: To date, no systematic analyses are available assessing concordance of molecular classifications between primary tumors (PT) and matched liver metastases (LM) of metastatic colorectal cancer (mCRC). We investigated concordance between PT and LM for four clinically relevant CRC gene signatures. Twenty-seven fresh and 55 formalin-fixed paraffin-embedded pairs of PT and synchronous LM of untreated mCRC patients were retrospectively collected and classified according to the MSI-like, BRAF-like, TGFB activated-like and the Consensus Molecular Subtypes (CMS) classification. We investigated classification concordance between PT and LM and association of TGFBa-like and CMS classification with overall survival. Fifty-one successfully profiled matched pairs were used for analyses. PT and matched LM were highly concordant in terms of BRAF-like and MSI-like signatures, (90.2% and 98% concordance, respectively). In contrast, 40% to 70% of PT that were classified as mesenchymal-like, based on the CMS and the TGFBa-like signature, respectively, lost this phenotype in their matched LM (60.8% and 76.5% concordance, respectively). This molecular switch was independent of the microenvironment composition. In addition, the significant change in subtypes was observed also by using methods developed to detect cancer cell-intrinsic subtypes. More importantly, the molecular switch did not influence the survival. PT classified as mesenchymal had worse survival as compared to nonmesenchymal PT (CMS4 vs CMS2, hazard ratio [HR] = 5.2, 95% CI = 1.5-18.5, P = .0048; TGFBa-like vs TGFBi-like, HR = 2.5, 95% CI = 1.1-5.6, P = .028). The same was not true for LM. Our study highlights that the origin of the tissue may have major consequences for precision medicine in mCRC.
The prospects for a new search for the electron electric dipole moment in solid Gadolinium iron garnet ceramics
Creators: name: Sushkov, A. O.
name: Eckel, S.
name: Lamoreaux, S. K.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We address a number of issues regarding solid state electron electric dipole moment (EDM) experiments, focusing on gadolinium iron garnet (abbreviated GdIG, chemical formula Gd$_3$Fe$_5$O$_{12}$) as a possible sample material. GdIG maintains its high magnetic susceptibility down to 4.2 K, which enhances the EDM-induced magnetization of a sample placed in an electric field. We estimate that lattice polarizability gives rise to an EDM enhancement factor of approximately 20. We also calculate the effect of the demagnetizing field for various sample geometries and permeabilities. Measurements of intrinsic GdIG magnetization noise are presented, and the fluctuation-dissipation theorem is used to compare our data with the measurements of the imaginary part of GdIG permeability at 4.2 K, showing good agreement above frequencies of a few hertz. We also observe how the demagnetizing field suppresses the noise-induced magnetic flux, confirming our calculations. The statistical sensitivity of an EDM search based on a solid GdIG sample is estimated to be on the same level as the present experimental limit. Such a measurement would be valuable, given the completely different methods and systematics involved. The most significant systematics in such an experiment are the magnetic hysteresis and the magneto-electric effect. Our analysis shows that it should be possible to control these at the level of statistical sensitivity.
Developing a Nationwide Infrastructure for Therapeutic Drug Monitoring of Targeted Oral Anticancer Drugs: The ON-TARGET Study Protocol
Creators: name: Mc Laughlin, Anna M.
name: Schmulenson, Eduard
name: Teplytska, Olga
name: Zimmermann, Sebastian
name: Opitz, Patrick
name: Groenland, Stefanie L.
name: Huitema, Alwin D. R.
name: Steeghs, Neeltje
name: Müller, Lothar
name: Fuxius, Stefan
name: Illerhaus, Gerald
name: Joerger, Markus
name: Mayer, Frank
name: Fuhr, Uwe
name: Holdenrieder, Stefan
name: Hempel, Georg
name: Scherf-Clavel, Oliver
name: Jaehde, Ulrich
name: Kloft, Charlotte
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: therapeutic drug monitoring
subject: oral anticancer drugs
subject: renal cell carcinoma
subject: volumetric absorptive microsampling
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Exposure-efficacy and/or exposure-toxicity relationships have been identified for up to 80% of oral anticancer drugs (OADs). Usually, OADs are administered at fixed doses despite their high interindividual pharmacokinetic variability resulting in large differences in drug exposure. Consequently, a substantial proportion of patients receive a suboptimal dose. Therapeutic Drug Monitoring (TDM), i.e., dosing based on measured drug concentrations, may be used to improve treatment outcomes. The prospective, multicenter, non-interventional ON-TARGET study (DRKS00025325) aims to investigate the potential of routine TDM to reduce adverse drug reactions in renal cell carcinoma patients receiving axitinib or cabozantinib. Furthermore, the feasibility of using volumetric absorptive microsampling (VAMS), a minimally invasive and easy to handle blood sampling technique, for sample collection is examined. During routine visits, blood samples are collected and sent to bioanalytical laboratories. Venous and VAMS blood samples are collected in the first study phase to facilitate home-based capillary blood sampling in the second study phase. Within one week, the drug plasma concentrations are measured, interpreted, and reported back to the physician. Patients report their drug intake and toxicity using PRO-CTCAE-based questionnaires in dedicated diaries. Ultimately, the ON-TARGET study aims to develop a nationwide infrastructure for TDM for oral anticancer drugs.
Sequential decision schemes for statistical pattern recognition problems with dependent and independent hypotheses
Creators: name: Hussain, Abul Bashar Shahidul
Publisher: name: University of British Columbia
Year: 2011

description: Sequential decision schemes for the purpose of both pattern classification and feature ordering are investigated. An optimum compound sequential probability ratio test (OCSPRT) for recognition problems with memory in the source as well as the observation medium is developed. The results of theoretical analysis and computer simulation of the OCSPRT for a two-class problem with first order Markov dependence among the pattern classes are presented. For multiclass recognition problems the suitability of Bayes sequential decision schemes based on one-state ahead truncation approximation, with and without on-line feature ordering, is assessed from the points of view of computational complexity and expected cost of a terminal decision. The Bayes sequential decision scheme for dependent hypothesis problems is formulated and its performance is compared with that of the optimum compound nonsequential decision scheme. For dependent hypothesis recognition problems, compound sequential pattern recognition schemes (CSPRS) are formulated. In CSPR schemes the required additional feature is observed either on the pattern to be decided, as in the classical sequential schemes, or on any one of the neighbouring patterns. The pattern selected and the feature actually observed are the ones which provide the maximum amount of additional information. The results of analytical and experimental evaluation of the CSPR schemes are presented. The suitability of the suboptimal sequential decision scheme with on-line ordering of features as a feature evaluation and ordering criterion is discussed. A modified on-line sequential (MOLS) decision scheme based on limited length of search is proposed as a compromise between the additional computational complexity and improvement in the recognition performance resulting from the on-line ordering of features. The advantage of incorporating such limited length of search over available features into sequential decision schemes using a set of preordered features is also examined. For the purpose of experimental evaluation of the various decision schemes, recognition of handprinted English text as a particular example of a pattern recognition problem was simulated on a digital computer. The handprinted characters were obtained from Munson's multiauthor data file prepared at Stanford Research Institute.
Decay eta_b->J/ψJ/ψin light cone formalism
Creators: name: Braguta, V. V.
name: Kartvelishvili, V. G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The decays of pseudoscalar bottomonium eta_b into a pair of vector charmonia, J/ψJ/ψ, J/ψψ', ψ' ψ' are considered in the light cone formalism. Relativistic and leading logarithmic radiative corrections to the amplitudes of these processes are resummed. It is shown that the small value for the branching ratio of the decay eta_b-> J/ψJ/ψobtained within the leading order nonrelativistic QCD is a consequence of a fine-tuning between certain parameters, which is broken when relativistic and leading logarithmic radiative corrections are taken into account. As a result, the branching ratio obtained in this paper is enhanced by an order of magnitude.
description: 7 pages, 1 figure
Two-loop corrections to the Lamb shift
Creators: name: Dowling, Matthew
name: Mondejar, Jorge
name: Piclum, Jan H.
name: Czarnecki, Andrzej
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a new calculation of the order alpha^2 (Z alpha)^5 correction to the Lamb shift, which uses methods developed for multi-loop calculations.
description: 5 pages, 3 figures, presented at RADCOR 2009
Ultraviolet and extreme-ultraviolet line ratio diagnostics for O IV
Creators: name: Keenan, F P
name: Crockett, P J
name: Aggarwal, K M
name: Jess, D B
name: Mathioudakis, M
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Aims: We generate theoretical ultraviolet and extreme-ultraviolet emission line ratios for O IV and show their strong versatility as electron temperature and density diagnostics for astrophysical plasmas. Methods: Recent fully relativistic calculations of radiative rates and electron impact excitation cross sections for O IV, supplemented with earlier data for A-values and proton excitation rates, are used to derive theoretical O IV line intensity ratios for a wide range of electron temperatures and densities. Results: Diagnostic line ratios involving ultraviolet or extreme-ultraviolet transitions in O IV are presented, that are applicable to a wide variety of astrophysical plasmas ranging from low density gaseous nebulae to the densest solar and stellar flares. Comparisons with observational data, where available, show good agreement between theory and experiment, providing support for the accuracy of the diagnostics. However, diagnostics are also presented involving lines that are blended in existing astronomical spectra, in the hope this might encourage further observational studies at higher spectral resolution.
description: 5 pages; 8 figures; Astronomy and Astrophysics, in press
MOESM4 of Comparative transcriptome and metabolome analyses provide new insights into the molecular mechanisms underlying taproot thickening in Panax notoginseng
Creators: name: Li, Xue-Jiao
name: Yang, Jian-Li
name: Hao, Bing
name: Lu, Ying-Chun
name: Qian, Zhi-Long
name: Li, Ying
name: Ye, Shuang
name: Tang, Jun-Rong
name: Chen, Mo
name: Long, Guang-Qiang
name: Zhao, Yan
name: Zhang, Guang-Hui
name: Chen, Jun-Wen
name: Fan, Wei
name: Yang, Sheng-Chao
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology

description: Additional file 4: Table S2. Statistics analysis of TFs gene expression in taproot thickening in P. notoginseng.
ReWiKs - Das war erst das Vorspiel! - Überblick zur digitalen Abschlusstagung 30.11.23
Creators: name: Krüger, Tim
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: Präsentation
Abschlusstagung
ReWiKs
Fortbildungen
Freiraum-Gruppen
Sexuelle Selbstbestimmung
Behinderung
Sexualität
Menschen mit Behinderungen
Menschen mit Lernschwierigkeiten
Ausblick 2024

description: Präsentation gezeigt auf der digitalen Abschlussveranstaltung des ReWiKs-Projekts am 30.11.23.

Erste Ergebnisse aus den drei Bereichen Fortbildung, Freiraum-Gruppen, Material des ReWiKs-Projektes inklusive einer Einführung in das Projekt.
Beam dynamics and wake-field simulations for the CLIC main linacs
Creators: name: Khan, V.
name: Jones, R. M.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The CLIC linear collider aims at accelerating multiple bunches of electrons and positrons and colliding them at a centre of mass energy of 3 TeV. These bunches will be accelerated through X-band linacs, operating at an accelerating frequency of 12 GHz. Each beam readily excites wake-fields within the accelerating cavities of each linac. The transverse components of the wake-fields, if left unchecked, can dilute the beam emittance. The present CLIC design relies on heavy damping of these wake-fields in order to ameliorate the effects of the wake-fields on the beam emittance. Here we present initial results on simulations of the long-range wake-fields in these structures and on beam dynamics simulations. In particular, detailed simulations are performed, on emittance dilution due to beams initially injected with realistic offsets from the electrical centre of the cavities.
description: 3 Pages. To be published in proceedings of LINAC 2008, Victoria, Canada
Pre-service Biology Teachers’ Responses to First-Hand Anomalous Data During Modelling Processes
Creators: name: Meister, Sabine
name: Krell, Moritz
name: Göhner, Maximilian
name: Upmeier Zu Belzen, Annette
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Anomalous data
subject: Modelling
subject: Pre-service science teachers
subject: Scientific thinking
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::378 Hochschulbildung

description: In this research project we investigate the role of responses to anomalous data during modelling processes. Modelling is seen as a comprehensive practice that encompasses various aspects of scientific thinking; hence, it is an important style of scientific thinking, especially if analysed from a process-based perspective. Therefore, it provides the opportunity to understand the role of anomalous data on scientific thinking from a broader perspective. We analysed how pre-service biology teachers (N = 11) reacted to self-generated anomalous data during modelling processes induced by investigating a water black box. The videotaped and transcribed modelling processes were analysed using qualitative content analysis. If anomalous data were recognised, a majority of explanations were based on methodical issues. This finding supports results from previous studies investigating responses to first-hand anomalous data. Furthermore, we found four response patterns to anomalous data during modelling processes: no recognition, no explanation, methodical explanation, and model-related explanation. Besides, our study indicates by trend a systematic relation between response patterns to anomalous data and modelling strategies. Consequently, the improvement of responses to anomalous data could be a promising way to foster modelling competencies. We are convinced that an integrated approach to anomalous data and modelling could lead to deeper insights into the role of data in scientific thinking processes.
Extracting spatial data from historic artwork of Hobart and its region
Creators: name: Farag-Miller, M
Publisher: name: University Of Tasmania
Year: 2023

description: The integration of spatial techniques with art can potentially provide information on past environments and culture. Nineteenth century landscape artwork from Hobart was examined to assess the accuracy of artists by applying photogrammetric techniques. Four prominent artists of the time, each from different backgrounds, varied markedly in their accuracy of depiction of landscapes. Computation of areas on artworks dedicated to features, such as forests, sky and fields, highlighted the significance of the social background and profession of the artist in composition. While gender did not affect the feature composition of works, the media used by 19th century females were restricted to drawing and water colour. To demonstrate the potential for integration of historical and spatial processes, forest clearance boundaries were mapped and dated from raw data of 19th Century paintings and photographs and later aerial photographs. Keywords: Historical artwork, features, spatial analysis, Hobart region.
Beta-gamma systems and the deformations of the BRST operator
Creators: name: Zeitlin, Anton M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We describe the relation between simple logarithmic CFTs associated with closed and open strings, and their "infinite metric" limits, corresponding to the beta-gamma systems. This relation is studied on the level of the BRST complex: we show that the consideration of metric as a perturbation leads to a certain deformation of the algebraic operations of the Lian-Zuckerman type on the vertex algebra, associated with the beta-gamma systems. The Maurer-Cartan equations corresponding to this deformed structure in the quasiclassical approximation lead to the nonlinear field equations. As an explicit example, we demonstrate, that using this construction, Yang-Mills equations can be derived. This gives rise to a nontrivial relation between the Courant-Dorfman algebroid and homotopy algebras emerging from the gauge theory. We also discuss possible algebraic approach to the study of beta-functions in sigma-models.
description: LaTeX2e, 15 pages; minor revision, typos corrected, Journal of Physics A, in press
Beyond the Relativistic Point Particle: A Reciprocally Invariant System and its Generalisation
Creators: name: Pavsic, Matej
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate a reciprocally invariant system proposed by Low and Govaerts et al., whose action contains both the orthogonal and the symplectic forms and is invariant under global $O(2,4)\cap Sp(2,4)$ transformations. We find that the general solution to the classical equations of motion has no linear term in the evolution parameter, $τ$, but only the oscillatory terms, and therefore cannot represent a particle propagating in spacetime. As a remedy, we consider a generalisation of the action by adopting a procedure similar to that of Bars et al., who introduced the concept of a $τ$ derivative that is covariant under local Sp(2) transformations between the phase space variables $x^μ(τ)$ and $p^μ(τ)$. This system, in particular, is similar to a rigid particle whose action contains the extrinsic curvature of the world line, which turns out to be helical in spacetime. Another possible generalisation is the introduction of a symplectic potential proposed by Montesinos. We show how the latter approach is related to Kaluza-Klein theories and to the concept of Clifford space, a manifold whose tangent space at any point is Clifford algebra Cl(8), a promising framework for the unification of particles and forces.
description: 15 pages; Revised version, accepted for publication in Physics Letters B
Generalized Mittag-Leffler Distributions and Processes for Applications in Astrophysics and Time Series Modeling
Creators: name: Jose, K. K.
name: Uma, P.
name: Lekshmi, V. Seetha
name: Haubold, H. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Geometric generalized Mittag-Leffler distributions having the Laplace transform $\frac{1}{1+β\log(1+t^α)},00$ is introduced and its properties are discussed. Autoregressive processes with Mittag-Leffler and geometric generalized Mittag-Leffler marginal distributions are developed. Haubold and Mathai (2000) derived a closed form representation of the fractional kinetic equation and thermonuclear function in terms of Mittag-Leffler function. Saxena et al (2002, 2004a,b) extended the result and derived the solutions of a number of fractional kinetic equations in terms of generalized Mittag-Leffler functions. These results are useful in explaining various fundamental laws of physics. Here we develop first-order autoregressive time series models and the properties are explored. The results have applications in various areas like astrophysics, space sciences, meteorology, financial modeling and reliability modeling.
description: 12 pages, LaTeX
Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations
Creators: name: Bao, Huayin
name: Wang, Wei
name: Sun, Haibo
name: Chen, Jianzhong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Mutations highly affect the structural flexibility of two switch domains in M-RAS considered an important target of anticancer drug design. Gaussian accelerated molecular dynamics (GaMD) simulations were applied to probe the effect of mutations P40D, D41E, and P40D/D41E/L51R on the conformational transition of the switch domains from the GTP-bound M-RAS. The analyses of free energy landscapes (FELs) not only reveal that three mutations induce less energetic states than the wild-type (WT) M-RAS but also verify that the switch domains are extremely disordered. Principal component analysis (PCA) and dynamics analysis suggest that three mutations greatly affect collective motions and structural flexibility of the switch domains that mostly overlap with binding regions of M-RAS to its effectors, which in turn disturbs the activity of M-RAS. The analyses of the interaction network between GTP and M-RAS show that the high instability in hydrogen bonding interactions (HBIs) of GTP with residue 41 and Y42 in the switch domain I drives the disordered states of the switch domains. This work is expected to provide a molecular mechanism for deeply understanding the function of M-RAS and future drug design towards the treatment of cancers.
Matrix Product States: Symmetries and Two-Body Hamiltonians
Creators: name: Sanz, M.
name: Wolf, M. M.
name: Perez-Garcia, D.
name: Cirac, J. I.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We characterize the conditions under which a translationally invariant matrix product state (MPS) is invariant under local transformations. This allows us to relate the symmetry group of a given state to the symmetry group of a simple tensor. We exploit this result in order to prove and extend a version of the Lieb-Schultz-Mattis theorem, one of the basic results in many-body physics, in the context of MPS. We illustrate the results with an exhaustive search of SU(2)--invariant two-body Hamiltonians which have such MPS as exact ground states or excitations.
description: PDFLatex, 12 pages and 6 figures
The dissolution of platinum-iron alloys in oxygeneted acid chloride solutions
Creators: name: Scott, John Wilfred
Publisher: name: University of British Columbia
Year: 2011

description: The dissolution of platinum from platinum iron alloys in oxygenated hydrochloric acid/sodium chloride solutions has been investigated using an autoclave technique. The dissolution rate was found to be dependent on alloy composition, acid concentration, and oxygen pressure. The dissolution followed typical corrosion kinetics and analysis of the results indicated that the cathodic reduction of oxygen was the rate controlling step in the dissolution reaction, at high chloride ion concentrations. An apparent activation energy of 16.8 kcal per mold was found for the dissolution of PtFe alloys, and 19 kcal per mole for pure Pt sheet.
Disparities in Spousal Desired Fertility and Land Tenure Expectations: Experimental Evidence from Rural Tanzania
Creators: name: Herrera-Almanza, Catalina
name: McCarthey, Aine Seitz
Publisher: name: Unknown
Year: 2023
Subjects: subject: Consumer/Household Economics
subject: Farm Management
subject: Labor and Human Capital
subject: Intrahousehold bargaining
subject: fertility
subject: randomized experience
subject: fertility preferences

description: Fertility decline in rural sub-Saharan Africa has lagged behind other developing countries. The gap in fertility preferences between men and women plays a pivotal role in determining household fertility and reproductive health outcomes, with men desiring more children and exerting more significant influence in household decision-making. This disparity becomes more pronounced in rural regions where patrilineal norms, especially those associated with land inheritance, remain prevalent. We estimate the effect of an informational family planning intervention on male and female fertility preferences in rural Tanzania. The experiment consisted of randomizing household consultations on modern contraception, with sessions conducted either jointly for husbands and wives or exclusively for wives in private. Surprisingly, husbands who engaged in joint consultations increased their desired additional number of children, and their wives mirrored this increase in fertility preferences. In contrast, women in private consultations reduced their additional desired number of children while their husbands’ preferences remained unchanged. We provide suggestive evidence that the unintended effects on fertility preferences might be motivated by land inheritance expectations, as our results are driven by households with firstborn daughters (rather than sons).
Left dissent : the Australian commercial news media's characterisation of 21st century protests critical of capitalism
Creators: name: Eiszele, JS
Publisher: name: University Of Tasmania
Year: 2023

description: 21st Century protests critical of capitalism feature prominently in Australian commercial news media. Because the individuals in these protests criticise the social and economic system commercial news media operates within, this raises questions about how these protests and protesters are characterised in news coverage. To explore the issue, this thesis analysed the newspaper reportage of the Occupy Melbourne City Square protest (October 2011) and the Brisbane G20 protests (November 2014) in Australia over two week reporting periods. A framing analysis was conducted to identify the dominant frames by which the protests and those involved were characterised, with a focus on the framing devices of language choice and source selection. Based on these approaches, several findings were made. Both protests were predominantly framed in terms of conflict. This included both verbal hostility and violent conflict between protesters and government, or between protesters and police. The newspapers' focus on physical conflict or the potential for physical conflict served to support a framing of the protests as dangerous, particularly for innocent bystanders. An economic consequences frame was also identified. This was exemplified in the foregrounding of the protest's negative impacts on local businesses. Correspondingly, the perspectives of representatives of the business fraternity and business operators predominated within the news coverage. Overall, this was consistent with the use of sources throughout the newspaper reportage, where elite voices from the government and police establishment predominated and served to support the characterisation of the protests and protesters in typically negative ways. However, the study also found that protesters, as news sources, were able to articulate counter-frames and, at times, define their own characterisations within the news texts, albeit to a far lesser extent than the elite sources. As a result, the newspaper coverage was characterised by only minimal engagement with the causes of the radical protest groups, which seemed to negate the purpose of the protests (to raise awareness of the groups' objectives). News frames were instead constructed in accordance with the agendas of primary definers, such as the police and government. This is significant because it highlights the potential limitations of Australian commercial news media within a liberal capitalist democracy.
Optimal covariant measurements: the case of a compact symmetry group and phase observables
Creators: name: Carmeli, Claudio
name: Heinosaari, Teiko
name: Pellonpää, Juha-Pekka
name: Toigo, Alessandro
Publisher: name: arXiv
Year: 2008
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study various optimality criteria for quantum observables. Observables are represented as covariant positive operator valued measures and we consider the case when the symmetry group is compact. Phase observables are examined as an example.
Additional file 1: of A statistical measure for the skewness of X chromosome inactivation based on family trios
Creators: name: Xu, Si-Qi
name: Zhang, Yu
name: Wang, Peng
name: Liu, Wei
name: Wu, Xian-Bo
name: Zhou, Ji-Yuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Appendix A. Derivation of P(FMC| D) in Table 1. Appendix B. Choice of initial value of θ (θ0) and MLE of θ (θ0) using family trios with missing parental genotypes. Appendix C. Inapplicability of ECM algorithm when using only single daughters. Appendix D. Contribution of single daughters to estimate of θ in ECM algorithm. Appendix E. Effect of different initial values of θ (θ0) on ECM algorithm. Tables S1–S3. The conditional probabilities and conditional expectations for seven types of possible mother-daughter pairs, four types of possible father-daughter pairs and three types of possible single daughters, respectively. Tables S4–S5. Statistical properties of likelihood-based confidence interval of γ against missing pattern (MP) and γ with ρ=0.05, (pm, pf) = (0.30, 0.30), (0.25, 0.30) and (0.30, 0.25), and λ2=1.5 and 2, respectively. Tables S6–S9. Statistical properties of likelihood-based confidence interval of γ against missing pattern (MP) and γ with (pm, pf)= (0.20, 0.20), (0.15, 0.20) and (0.20, 0.15), ρ=0 and 0.05, and λ2=1.5 and 2, respectively. Table S10. Averages of absolute differences of each element of θ ̂ $$ \widehat{\theta} $$ and ln L θ ̂ $$ \ln L\left(\widehat{\theta}\right) $$ between ECM1 and ECM1000 with ρ=0, λ2= 1.5 and (pm, pf) = (0.30, 0.30) under MP1-MP6. Table S11. Averages of absolute differences of each element of θ ˜ 0 $$ {\tilde{\theta}}_0 $$ and ln L θ ˜ 0 $$ \ln L\left({\tilde{\theta}}_0\right) $$ between ECM1/ECM10 and ECM1000 with ρ=0, λ2= 1.5 and (pm, pf) = (0.30, 0.30) under MP1-MP6. Figures S1–S2. Medians of point estimates of γ against MP for different pm, pf and λ2 values with ρ=0 and 0.05, respectively. Figures S3–S6. Estimated powers of LRT against γ with ρ=0.05 and (pm, pf) being (0.30, 0.30), (0.25, 0.30) and (0.30, 0.25) under MP1–MP4 and MP5–MP6, and λ2=1.5 and 2, respectively. Figures S7–S14. Estimated powers of LRT against γ with (pm, pf) being (0.20, 0.20), (0.15, 0.20) and (0.20, 0.15) under MP1–MP4 and MP5–MP6, ρ=0 and 0.05, and λ2=1.5 and 2, respectively. (PDF 2328 kb)
Looking for New Physics in B --> K^* πand B --> ρK Decays
Creators: name: Chiang, Cheng-Wei
name: London, David
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: B --> K^* πand B --> ρK decays involve the same quark-level processes as B --> πK. Analyzing the measurements of the former decays might be able to shed additional light on the new-physics hints in the current B --> πK data. We perform fits to B --> K^* πand B --> ρK decays, and find that the data can be accommodated within the standard model. However, this agreement is due principally to the large errors in the data, particularly the CP-violating asymmetries. If the errors on the B --> K^* πand B --> ρK observables can be reduced, one will have a clearer sense of whether new physics is present in these decays.
description: 12 pages and 6 plots; version to appear in journal
Valuing the Tarkine : a systematic quantification of optimal land use and potential conflict compromise
Creators: name: Evans, JD
Publisher: name: University Of Tasmania
Year: 2023

description: Ecosystems continue to deplete as global demand for natural resources force land use change and cause environmental conflict. Optimal land use that considers both the significance of ecosystems and the sustainable human consumption of natural resources is required. Thus, the primary aim of the thesis was to develop an integrated approach to resolving land use conflict using the Tarkine as an exemplar. Land use change and environmental conflict are influenced by complex socio-economic factors and necessitate systematic resolution practices that address deep disagreement on values. This thesis fills a research gap by providing a systematic quantification of optimal land use and potential conflict compromise that integrates attitudes, preferences and economic values. The spatial patterns of optimal land use in the Tarkine are established using two approaches: a) the a priori approach to determine the different levels of significance and the relative worth of values and b) the a posteriori approach to determine the importance of values to people. The heritage importance of conservation values in the Tarkine was determined using their level of significance, legal recognition of importance, area in relation to Tasmania, Australia and the world, rarity, and distinctiveness. Aboriginal cultural heritage, coastal interdigitation, rainforest river landscapes and wild Dasyuridae habitats may meet criteria for World Heritage listing. Aboriginal cultural heritage, biodiversity and wilderness values may increase in the future. The international significance of the Aboriginal cultural landscape in the Tarkine has not been fully determined. Cost-benefit analysis, variable discount rates, time frames and output multipliers were used to calculate economic values. There is high economic potential for carbon and tourism development in the Tarkine, and localised potential for mining. However, the application of output multipliers changes the results creating large areas of forest with greater economic value than tourism and carbon combined. A novel reciprocal triangulation of data using attitudes and participant mapping found that conflict is multidimensional; that informed discussion of values leads to increased willingness to compromise potential outcomes; and, that variation in such willingness is predictable. A practical example suggests a way forward to resolve conflict in the Tarkine through applying a second iteration of the research findings to quantify future trade-offs and advance conflict resolution processes.
High-resolution spectroscopy of triplet states of Rb2 by femtosecond pump-probe photoionization of doped helium nanodroplets
Creators: name: Mudrich, M.
name: Heister, Ph.
name: Hippler, T.
name: Giese, Ch.
name: Dulieu, O.
name: Stienkemeier, F.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The dynamics of vibrational wave packets in triplet states of rubidium dimers (Rb2) formed on helium nanodroplets are studied using femtosecond pump-probe photoionization spectroscopy. Due to fast desorption of the excited Rb2 molecules off the droplets and due to their low internal temperature, wave packet oscillations can be followed up to very long pump-probe delay times >1.5ns. In the first excited triplet state (1)^3Σ_g^+, full and fractional revivals are observed with high contrast. Fourier analysis provides high-resolution vibrational spectra which are in excellent agreement with ab initio calculations.
Veille.science : une veille et intelligence scientifique en SHS à destination des décideurs
Creators: name: POUYLLAU, Stéphane
Publisher: name: Zenodo
Year: 2016
Subjects: IST
Veille scientifique
moteur de recherche

description: Le web sémantique et l’ouverture des données (publications, archives, référentiels) dans les sciences humaines et sociales (SHS) ont permis la création outils de recherche nouveaux permettant à la fois de créer des portails web (autour de moteurs de recherche sémantiques) et des applications on demand. ISIDORE (https://isidore.science), l’accès unifié aux données, publications et informations des SHS entre dans cette catégorie. Il contient 6 millions de ressources numériques en SHS (articles, données textuelles et audiovisuelles, référentiels issus du monde scientifique et culturel) collectées dans plus de 7000 gisements de données en France et à l’international. Lancé en 2010 par le CNRS et actuellement développé par Huma-Num, ISIDORE propose, outre un moteur de recherche sur le web, une collection d’applications permettant de l’utiliser de façon « embarqué » pour des usages aux plus près des besoins des enseignants-chercheurs et des étudiants. Le projet Veille.science en est un exemple.
Field test : Heptamaloxyloglucan and Sorbitol sprayed on grapevines does not provide -3 C spring frost protection in Canada
Creators: name: Gagne, Fabien
Publisher: name: figshare
Year: 2021
Subjects: subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: Plant Biology
subject: FOS: Biological sciences

description: Heptamaloxyloglucan and Sorbitol, together commercialized as PEL101GV, was applied on Frontenac hybrid grapevines at 60 mg/ha and 100 g/ha respectively, 43 hours prior to a spring frost event in the Montérégie region (Quebec, Canada). In the test plot, the minimum temperature varied between -3.1 oC to -3.7 oC, as measured at the 70 cm shoot's height. The agents were compared to no-treatment in a complete randomized test block with 13 repetitions. The average shoot survival rate was 15.9% and 14.5% for the agent and the no-treatment respectively, but data analysis shows no statistical significance with p = 0.577. Data suggests that shoot survival rate is correlated to the physical position in the field. In the conditions tested, Heptamaloxyloglucan and Sorbitol were not effective at protecting against spring frost.
Evaluation of an Early Intervention Model for Child and Adolescent Victims of Interpersonal Violence
Creators: name: Calvano, Claudia
name: Murray, Elena
name: Bentz, Lea
name: Bos, Sascha
name: Reiter, Kathrin
name: Ihme, Loretta
name: Winter, Sibylle M.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: children and adolescents
subject: clinical practice
subject: early intervention
subject: interpersonal violence
subject: sexual abuse
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Only the minority of youth exposed to traumatic events receive mental health care, as trauma-informed clinical services are lacking or are poorly accessible. In order to bridge this gap, the Outpatient Trauma Clinic (OTC) was founded, an easily accessible early, short-time intervention, with onward referral to follow-up treatment. This report presents the OTC’s interventional approach and first outcome data. Using a retrospective naturalistic design, we analyzed trauma- and intervention-related data of the sample (n = 377, 55.4% female, mean age 10.95, SD = 4.69). Following drop-out analyses, predictors for treatment outcome were identified by logistic regression. The majority (81.9%) was suffering from posttraumatic stress disorder (PTSD) or adjustment disorders. Around one forth dropped out of treatment; these cases showed higher avoidance symptoms at presentation. In 91%, psychological symptoms improved. Experience of multiple traumatic events was the strongest predictor for poor treatment outcome (B = −0.823, SE = 0.313, OR = 0.439, 95% CI 0.238–0.811). Around two thirds were connected to follow-up treatment. The OTC realized a high retention rate, initial improvement of symptoms and referral to subsequent longer-term psychotherapeutic treatment in the majority. Further dissemination of comparable early intervention models is needed, in order to improve mental health care for this vulnerable group.
Ansätze zur visuell unterstützten Vergleichsanalyse von Konnektomdaten
Creators: name: Schwanke, Sebastian
Publisher: name: Universität Rostock
Year: 2018
Subjects: subject: 004 Data processing Computer sciences
subject: 610 Medical sciences Medicine

description: Der Vergleich von Konnektomen ist ein essentieller Schritt, um Veränderungen in Nervensystemen zu identifizieren. Die Analyse von Konnektomen und deren Vergleich erfordert vielfältige Methoden. Das plattformunabhängige und generische Framework neuroVIISAS stellt flexible Lösungen zu funktionellen und vergleichenden Fragestellungen zur Verfügung. Im Rahmen dieser Arbeit wird eine Methodik beschrieben, um verschiedene Konnektome mit vielfältigen analytischen und visuellen Methoden zu vergleichen. Die entwickelte Vergleichssystematik wird beschrieben und auf zwei Fragestellungen angewandt.
The Role of ESLEA in the development of eVLBI
Creators: name: Spencer, R. E.
name: Hughes-Jones, R.
name: Strong, M.
name: Casey, S.
name: Rushton, A.
name: Burgess, P.
name: Kershaw, S.
name: Greenwood, C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The internet has been used for data transfer in radio astronomy ever since its inception; however it is only recently that network bandwidth capability means that the internet becomes competitive with traditional forms of data storage. Very Long Baseline Interferometry (VLBI) uses widely separated telescopes between which high bandwidth direct connections have not been feasible until recently. The academic networks now allow us to connect at high data rates (~1Gbps) in "eVLBI". The ESLEA project (Exploitation of Switched Lightpaths for E-science Applications) has played a major role in the development of eVLBI. We outline this development in this paper.
description: 23 pages, to be published in Future Generation Computer Systems 26 (2010), pp. 111-119
A Cell Culture System to Investigate Marek’s Disease Virus Integration into Host Chromosomes
Creators: name: You, Yu
name: Vychodil, Tereza
name: Aimola, Giulia
name: Previdelli, Renato L.
name: Göbel, Thomas W.
name: Bertzbach, Luca D.
name: Kaufer, Benedikt B.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: MDV
subject: herpesvirus
subject: telomere integration
subject: in vitro assay
subject: telomeric repeats
subject: fluorescence in situ hybridization
subject: genome maintenance
subject: latency
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes a devastating neoplastic disease in chickens. MDV has been shown to integrate its genome into the telomeres of latently infected and tumor cells, which is crucial for efficient tumor formation. Telomeric repeat arrays present at the ends of the MDV genome facilitate this integration into host telomeres; however, the integration mechanism remains poorly understood. Until now, MDV integration could only be investigated qualitatively upon infection of chickens. To shed further light on the integration mechanism, we established a quantitative integration assay using chicken T cell lines, the target cells for MDV latency and transformation. We optimized the infection conditions and assessed the establishment of latency in these T cells. The MDV genome was efficiently maintained over time, and integration was confirmed in these cells by fluorescence in situ hybridization (FISH). To assess the role of the two distinct viral telomeric repeat arrays in the integration process, we tested various knockout mutants in our in vitro integration assay. Efficient genome maintenance and integration was thereby dependent on the presence of the telomeric repeat arrays in the virus genome. Taken together, we developed and validated a novel in vitro integration assay that will shed light on the integration mechanism of this highly oncogenic virus into host telomeres.