cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Muscle-specific gene expression in differentiated embryonal carcinoma cells.
Creators: name: Pari, Giovanna.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Genetics.

description: A chimeric gene consisting of the human cardiac actin promoter linked to the lac Z reporter gene encoding $\beta$-galactosidase ($\beta$-gal), was permanently transfected into P19 cells. Differentiation of these cultures into cardiac muscle resulted in high levels of $\beta$-gal activity, while differentiation along the neuroectodermal lineage did not lead to any increase in the expression of the actin-lacZ chimeric gene. The transcription of various muscle-specific genes can be activated in different nonmuscle cell lines by the expression of MyoD, a regulatory factor of skeletal myo-genesis. MyoD activates muscle-specific genes in cooperation with other factors which interact directly or indirectly at the various cis-acting regulatory sequences of the target gene. The role of MyoD in muscle differentiation was investigated in permanent transfections of P19 cells with the MyoD expression vector. MyoD transcripts were absent during the de novo differentiation of P19 cells into cardiac muscle. The myogenic differentiation program seems to be controlled by complex interactions among multiple upstream regulatory elements and myogenic factors that are functional only in the appropriate cellular context. (Abstract shortened by UMI.)
The UN Broadband Commission for Digital Development
Creators: name: Budde, Paul
Publisher: name: Swinburne
Year: 2024

description: High-speed broadband networks are an essential element in today's society, and access should be available on an equitable basis, worldwide. The infrastructure should have the same fundamental importance as the infrastructure associated with transport, power and water supply. This paper explores how that goal can be achieved, and describes the work being done by the UN Broadband Commission for Digital Development. The Commission is working towards making broadband cost-effective and affordable to all, and towards increasing Internet user penetration in developing, as well as developed, countries. It is currently leading a trans-sectoral project aimed at the worldwide eradication of malaria, which will use digital technology such as smartphones to enable cohesive, trans-sector communications.
Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin
Creators: name: Metz, Martin; ; ; Brehler, Randolf; Gericke, Janine; Kangas, Michael; Ashton- Chess, Joanna; Jarvis,
name: Staubach, Petra
name: Bauer, Andrea
name: Brehler, Randolf
name: Gericke, Janine
name: Kangas, Michael
name: Ashton-Chess, Joanna
name: Jarvis, Philip
name: Georgiou, Panayiotis
name: Canvin, Janice
name: Hillenbrand, Rainer
name: Erpenbeck, Veit J.
name: Maurer, Marcus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background. Treatment with omalizumab, a humanized recombinant monoclonal anti-IgE antibody, results in clinical efficacy in patients with Chronic Spontaneous Urticaria (CSU). The mechanism of action of omalizumab in CSU has not been elucidated in detail. Objectives. To determine the effects of omalizumab on levels of high affinity IgE receptor-positive (FcεRI+) and IgE- positive (IgE+) dermal cells and blood basophils. Treatment efficacy and safety were also assessed. Study design. In a double-blind study, CSU patients aged 18‑75 years were randomized to receive 300 mg omalizumab (n=20) or placebo (n=10) subcutaneously every 4 weeks for 12 weeks. Changes in disease activity were assessed by use of the weekly Urticaria Activity Score (UAS7). Circulating IgE levels, basophil numbers and levels of expression of FcεRI+ and IgE+ cells in the skin and in blood basophils were determined. Results. Patients receiving omalizumab showed a significantly greater decrease in UAS7 compared with patients receiving placebo. At Week 12 the mean difference in UAS7 between treatment groups was -14.82 (p=0.0027), consistent with previous studies. Total IgE levels in serum were increased after omalizumab treatment and remained elevated up to Week 12. Free IgE levels decreased after omalizumab treatment. Mean levels of FcεRI+ skin cells in patients treated with omalizumab 300 mg were decreased at Week 12 compared with baseline in the dermis of both non-lesional and lesional skin, reaching levels comparable with those seen in healthy volunteers (HVs). There were no statistically significant changes in mean FcɛRI+ cell levels in the placebo group. Similar results were seen for changes in IgE+ cells, although the changes were not statistically significant. The level of peripheral blood basophils increased immediately after treatment start and returned to Baseline values after the follow-up period. The levels of FcεRI and IgE expression on peripheral blood basophils were rapidly reduced by omalizumab treatment up to Week 12. Conclusions. Treatment with omalizumab resulted in rapid clinical benefits in patients with CSU. Treatment with omalizumab was associated with reduction in FcɛRI+ and IgE+ basophils and intradermal cells.
Analysis of stiffened and unstiffened slabs.
Creators: name: Bhalla, D. S. B.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1972
Subjects: subject: Engineering, Civil.

description: High Precision Finite elements have been used to determine displacements and internal forces of rectangular and skewed slabs. The displacement model is derived on the assumptions of small deflection theory and the principles of linear elasticity. The high precision triangular plate bending element with six degrees of freedom per node, developed by Cowper, Lindberg, Olson & Kosko has been used to study the behaviour of slabs under concentrated loads. A computer program is developed for the generation of the stiffness maxtrix of the individual elements. These matrices are used to represent the structure force-displacement relationships. To widen the scope of study, linear elastic members are incorporated and some problems of stiffened slabs are analysed. A compatible beam element is developed to represent the stiffeners. In the case of eccentric stiffeners in-plane forces are developed. To take the in-plane forces into account a complete cubic function is assumed for the tangential displacements. Comparisons with the existing solutions are made to establish the accuracy achieved on using high precision elements.
One wild hunt
Creators: name: Rosenberg, Amelia
Publisher: name: University of Iowa
Year: 2024

description: My artwork is a reckoning rooted in lineage, survival, and generational connection. Through ceramics I grapple with my own ability to endure as an echo of my German Jewish family's survival of WWII. By engaging with Flora and Fauna found in Bavarian folk textiles once produced by my great grandfather Moritz Wallach and his brothers Julius and Max, I illustrate my understanding of this history and its relationship to my own lived experience. The Wallach brothers were established as some of Munich’s most prized artisans before the Holocaust, and their legacy remains entwined with creative and personal upheaval post exile.
description: I employ folk creatures such as goats, geese, and rabbits to illustrate human action or reaction as very animal and instinctual. As someone who has been hunted and stalked, I question how many of the deep fears I have experienced emulate the past fears of my family. Becoming acquainted with fear has allowed me to deconstruct my understanding of survival, and in turn, see it reflected in the world around me. Creating animals who epitomize human emotion connects personal grief with universal reaction. The descriptive features of creatures such as horns, webbed feet, and long ears have become mirrors of my bodily understanding of fight, flight, freeze, and fawn responses.
description: I acknowledge reverence in survival and consider evolution a companion to fear. An abundance of floral and plant-like representations such as pomegranates, flowers, and strawberries pay homage to the kinship found between grief and reclamation. I think regularly of my Grandmother Ann, who fled Germany in 1938 at age 19 and carried a combination of sweetness and laughter throughout her long life. My experience of hardship continues to evolve towards a more realized, practiced understanding of joy. I revel in the translation of experience between generations, and with the creation of my art I work to understand how truly close we are.
3701800.pdf
Creators: name: Zektzer, Roy
name: Talker, Eliran
name: Barash, Yefim
name: Mazurski, Noa
name: Levy, Uriel
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Chiral light matter interaction in hot vapor cladded waveguides: supplementary material
Genetic and molecular characterization of origins of replication from beta-lactamase-producing plasmids of Neisseria gonorrhoeae.
Creators: name: Pagotto, Franco Joesph.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Biology, Microbiology.

description: This work represents a comprehensive analysis of the precise structural relationship and organization existing amongst the gonococcal beta-lactamase-producing plasmids. The second major aspect of this work deals with investigations into the genetic and molecular characterization of the multiple origins of replication of the gonococcal beta-lactamase-producing plasmids. The Asia-plasmid, pJD4, a prototype gonococcal beta-lactamase-producing plasmid, is 7,426 bp and contains two large, direct repeats (DR-30A, 507 bp and DR-30B, 509 bp) which are implicated in the formation of deletion variant plasmids, such as the naturally-occurring Africa-type plasmid. The deletion observed in Africa-type plasmids, represented by pJD5, is 1,827 bp. One of the DR-30 repeats is also missing in the formation of Africa plasmids. The deletion in the Rio-type and several Toronto-type is 2,273 bp and the sequence spanning the deletion was identical irrespective of geographic or temporal origin. Thus, the Rio and Toronto-type plasmids are identical. The Nimes-type plasmid is proposed to be identical to the Africa-type but contains an IS 5 insertion sequence. Since IS5 has not been identified in gonococcal isolates and is not present in the gonococcal genome, it is suggested that this sequence was inserted after the original gonococcal plasmid was transformed into a strain of Escherichia coli. The New Zealand plasmid was shown to be an Asia-type plasmid which contains an endogenous tandem duplication of 1,883 bp. The direct repeat DR-2 is implicated in this duplication. Branch-point analysis by electron microscopy indicated that the Asia-type plasmid contains three origins of replication, named ori1, ori2, and ori3. Although pJD4 belongs to the incompatibility (Inc) group IncW, it also carries a silent IncFII determinant which is expressed when ori2 and ori3 are absent. The Africa-type plasmid was shown to carry only oril, belongs to the IncFII group, and, in contrast to pJD4, requires DNA polymerase I for replication. Plasmid constructs from pJD4 lacking oril but carrying ori2 and ori3 are incompatible with IncW plasmids, suggesting the ori2/ori3 region contains the IncW determinant. A novel replication initiation protein, RepB, was identified and shown to be necessary for ori2 and ori3 to function. The RepB is distinct from RepA, the replication initiation protein required for plasmids carrying ori1. (Abstract shortened by UMI.)
title: Politikszenarien für den Klimaschutz VI - Treibhausgas-Emissionsszenarien bis zum Jahr 2030
title: Political Scenarios for Climate Protection VI - Greenhouse Gas Emissions Scenarios to 2030
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: Klimapolitik
Energiepolitik
Erneuerbare Energie

description: Es werden Szenarien für Energieverbrauch und Treibhausgasemissionen erstellt. Diese erfassen die Endverbrauchssektoren (Haushalte, GHD, Verkehr, Industrie) sowie die Umwandlungssektoren (Strom- und Fernwärmeerzeugung, andere Energiesektoren). Die Szenarien wurden über die Modellierungen sektorspezifischer politischer Maßnahmen und Ziele entwickelt. Berücksichtigt werden im Aktuelle-Politik-Szenario die im Zeitraum 2005 bis Mitte 2011 umgesetzten politischen Maßnahmen. Im Energiewende-Szenario werden zusätzliche energie- und klimapolitische Maßnahmen oder Zielvorgaben abgebildet. Das Basisjahr für die Szenarien ist 2008, der Szenariohorizont reicht bis 2030. Quelle: Forschungsbericht
description: Scenarios are developed for energy consumption and greenhouse gas emissions. These comprise the end-use sectors (residential, tertiary, transport, industry) as well as the energy transformation sectors (electricity and district heat production, other energy sectors). The scenarios were elaborated using modellings of sector-specific policy measures and targets. The policy measures implemented in the time period of 2005 to mid-201 1 are taken into account in the ´Current-Policy-Scenario´. In the ´Energy-Transformation- Scenario´, additional measures and targets of energy and climate policy are represented. The base year for the scenarios is 2008: the time horizon extends to 2030. Quelle: Forschungsbericht
Major and trace element analysis of the late Cambrian SPICE Event from the Rhinehart A-1 Core, Dallas County, IA
Creators: name: Barnes, Gwen Leann
Publisher: name: University of Iowa
Year: 2025
Subjects: Cambrian
Laurentia
Rare earth elements
SPICE event
public abstract
Trace Elements

description: The Steptoean Positive Carbon Isotope Excursion (SPICE) represents a major perturbation to the global carbon cycle during which carbon isotope (δ13Ccarb) values reach up to +4-5‰ in Upper Cambrian strata spanning several paleocontinents. This prominent global shift in δ13Ccarb is accompanied by biotic turnovers and upheavals in other biogeochemical cycles. New high-resolution trace metal and rare earth element data from the SPICE in central Iowa reveal significant enrichments of these elements that are consistent with changing marine redox conditions and a substantial increase in primary production around the event onset. Both of these factors play a critical role in attempting to decipher the dominant control(s) and sequence of events responsible for driving such a large biogeochemical event. These redox proxies cannot be applied to the global oceans; however, the relationships shown here between metal enrichment, nutrient cycling, deoxygenation of marine settings, and the onset of a widespread carbon cycle perturbation resemble those observed during other Phanerozoic biogeochemical events, ultimately serving as critical models when evaluating the biogeochemical signals preserved here as well as shedding more light on the evolution of the ocean-atmosphere-biosphere system.
Applicability of trials in rheumatoid arthritis and osteoarthritis: A systematic review and meta-analysis of trial populations showing adequate proportion of women, but underrepresentation of elderly people
Creators: name: Palmowski, Andriko
name: Buttgereit, Thomas
name: Palmowski, Yannick
name: Nielsen, Sabrina Mai
name: Boers, Maarten
name: Christensen, Robin
name: Buttgereit, Frank
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Applicability
subject: Generalizability
subject: Elderly
subject: Women
subject: Rheumatoid Arthritis
subject: Osteoarthritis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To evaluate whether elderly people and women are adequately represented in randomized controlled trials (RCT) in rheumatoid arthritis (RA) and osteoarthritis (OA). Methods: Four systematic searches in MEDLINE yielded RCT in RA and OA on any intervention published in 2016 and 2017 and population-based studies (PBS) in RA and OA published between 2013 and 2017. Random effects meta-analyses estimated the pooled proportion of elderly people (defined as being ≥ 65 years old), the mean age, its standard deviation (SD), and the proportion of women stratified by disease (RA and OA) and study type (RCT and PBS). Stratified estimates were subsequently compared. Results: 265 RCT comprising 51,240 participants and 53 PBS comprising 523,630 participants were included. In both RA and OA, RCT included lower proportions of elderly people than PBS: RA –0.18 (95% confidence interval –0.22 to –0.13); OA –0.20 (–0.30 to –0.09); had lower mean ages: RA –5.2 years (–6.8 to –3.5); OA –4.7 years (–7.5 to –2.0); and smaller SD: RA –1.9 years (–2.6 to –1.3); OA –2.7 years (–4.2 to –1.2); (all comparisons: p ≤ 0.001). Proportions of women were comparable in RCT compared to PBS in both RA and OA. Conclusions: While women are adequately represented in RA and OA trials, the elderly are underrepresented, probably limiting applicability of current evidence to this growing subgroup. It is urgent to improve the inclusion of elderly people in clinical trials and study age as a determinant for outcome.
Impacts of reindeer on soil carbon storage in the seasonally frozen ground of Northern Finland: A pilot study
Creators: name: Windirsch, Torben
name: Forbes, Bruce C.
name: Ulrich, Mathias
name: Große, Guido
Publisher: name: My University
Year: 2023

description: To test the effect of reindeer husbandry on soil carbon storage of seasonally frozen ground, we analysed soil and vegetation properties in peatlands and mixed pine and mountain birch forests. We analysed sites with no grazing and contrasting intensities of grazing, and associated trampling, in Northern Finland. With a pilot study approach, we optimised the study design to include several grazing class sites including grazing seasonality but omitting sample replication at one site. Soils were analysed for water content, bulk density, total organic carbon (TOC), total nitrogen, stable carbon isotopes and radiocarbon ages. We found that there was no significant difference between grazing intensities in terms of TOC, but that TOC mainly depended on the soils' TOC content present prior to intensive herbivory introduction. In contrast, understory vegetation was visibly transformed from dwarf shrub to graminoid-dominated vegetation with increasing grazing and trampling intensity. Also, we found a decrease in bulk density with increasing animal activity on soil sites, which most likely results from named vegetation changes and therefore different peat structures. Quelle: https://www.borenv.net/BER/archive/pdfs/ber28/ber28-207-226-abstract.htm
The politics of speed: An examination of national governments' policies for FTTX networks
Creators: name: Corner, Stuart
Publisher: name: Swinburne
Year: 2024

description: The Australian Labor Government's National Broadband Network plan to fund the rollout of a fibre-to-the-premises network that will serve 93 percent of premises represents a level of
government intervention towards achieving a goal of ubiquitous high-speed broadband that almost no other national government has been prepared to make. Its supporters, here and
abroad, point to its national benefits and its international leadership. Its detractors, particularly the Australian Parliamentary Opposition, cite the uniqueness of the undertaking and its
creation of a monopoly in fixed access infrastructure as evidence of its foolhardiness. This article examines the views of a selection of national governments on the desirability of ubiquitous high speed broadband and any plans or policies in place to achieve this. It concludes that most governments share the same goal of eventual ubiquitous high-speed
broadband access for their citizens, and notes that 82 percent of investment in FTTX in 2012-17 in the world’s developed countries is estimated to be in fibre-to-the-home (FTTH). But
their current policies reflect their starting points as much as their preferred time frames – and their ideologically preferred means of achieving their national goals.
On DP-constraints for the Traveling Salesman polytope.
Creators: name: Cockburn, Sally.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Engineering, System Science.

description: The DP-constraints are a recently defined class of valid inequalities for the Symmetric Traveling Salesman Polytope (STSP) which includes the family of comb constraints. Moreover, there exists a polynomial-time exact separation algorithm for the DP-constraints for points whose support graph is planar. However, while the comb constraints are known to be facet-inducing, the same is not true in general of the DP-constraints. This thesis addresses the question of which DP-constraints are facet-inducing; some sufficient conditions are given for identifying DP-constraints which are not facet-inducing, and a family of facet-inducing DP-constraints, the twisted comb constraints, is described and shown to be distinct from other known families of facet-inducing inequalities. We also present a new formulation of the DP-constraints in terms of tripartitions of the node set, which allows easier recognition of equivalent DP-constraints.
Quillen model structures, *-autonomous categories and adherence spaces
Creators: name: Egger, Jeffrey M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Mathematics.

description: Linear logic has been intensively studied since its introduction almost twenty years ago. Originally introduced as a proof theory, two distinct semantic traditions have evolved around linear logic: the denotational semantics of linear logic, and the Geometry of Interaction. In this thesis we explore how abstract homotopy theory may be used to reconcile these semantic traditions. This approach is in some sense already suggested by the fact that, in denotational semantics, one is forced to take equivalence classes of proofs, and not proofs per se, as morphisms. Our approach amounts to taking a coarser equivalence relation than is needed to construct a denotational model, in order to create a category more closely resembling those which occur in Geometry of Interaction. A new class of denotational models, called adherence spaces and in some sense tailor-suited to the problem at hand, are introduced. Then it is shown how a Quillen model structure may be imposed on a category of adherence spaces in such a way that the resulting homotopy category is compact closed.
title: Influence of Fusarium avenaceum infections on barley malt: Monitoring changes in the albumin fraction of barley during the malting process
title: Influence of Fusarium avenaceum infections on barley malt
titleType: AlternativeTitle
Creators: name: Geißinger, Cajetan
name: Heß, Michael
name: Whitehead, Iain
name: Hofer, Katharina
Publisher: name: My University
Year: 2019
Subjects: Gerste

description: Fusarium spp. are ubiquitous field pathogens, which are known to affect quality characteristics of cereals. Infections with Fusarium pathogens in brewing cereals are problematic and augur for a poor malt quality. The negative effects of Fusarium infections are various. Besides causing agronomic losses, kernel discoloration, and the production of several mycotoxins, Fusarium spp. are known to enhance the proteolytic activity of infected barley malt. Enhanced proteolysis can be observed in higher values in free amino nitrogen (FAN) as well as in soluble nitrogen. Previous studies showed that, in recent crop years, the predominant Fusarium spp. detected in European malt was F. avenaceum. This study focuses on the changes in the albumin fraction during the malting process of barley samples artificially infected with F. avenaceum in comparison to uninfected control samples. The barley samples were grown under controlled conditions in a greenhouse, and two different sample types were studied: One was not infected with Fusarium spores whereas the other sample was inoculated during anthesis with a spore suspension of F. avenaceum. Malting trials were carried out in a micromalting facility under defined conditions. To monitor the changes in protein profiles due to Fusarium infection, samples were analyzed at different stages of the malting process: barley (raw grain), poststeeping, postgermination, and postkilning. To evaluate the changes in the protein composition, different fractionation techniques (Osborne fractionation, isoelectric focusing, and capillary gel electrophoresis) were utilized. The albumins of the Osborne fractionation were further analyzed as they represent the main metabolically active proteins. Protein maps of the different malting steps were plotted with a custom-programmed visualization tool for comparing the infected and uninfected samples at each malting step. The results elucidate the changes in the albumin fraction during the malting process and reveal the influence of Fusarium infection on the albumin composition of barley, barley malt, and the intermediate products of malting. © 2019 Elsevier B.V. All rights reserved.
Intelligent document format: A text encoding scheme.
Creators: name: Tran, Charles.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Computer Science.

description: The issue of text representation is very important in text retrieval and natural language processing. The way the data is represented can significantly affect the efficiency of storage, retrieval, routing techniques, query formulation, and information extraction. This thesis describes a potential solution to encode documents efficiently and effectively so that information may be easily retrieved. In this thesis, we present a technique for encoding textual data in a representation format called the Intelligent Document Format (IDF). The IDF encodes English text so as to store textual data efficiently, permitting retrieval of text at sentence-, paragraph-, and document levels, and assisting term searching and retrieving as well as providing linguistic processing such as morphological analysis and sense disambiguation. To illustrate the IDF encoding method, we describe IDFconvert, an IDF encoder and decoder program, and carry out encoding experiments on the electronic-text version of Dracula (Stoker 1897).
Essays in the Economics of Education and Identity
Creators: name: McKendrick, Andrew
Publisher: name: Lancaster University
Year: 2022

description: This thesis covers three research topics, each separate chapter a distinct entity designed to be submitted to (and hopefully published in) a good quality journal. Both chapters 1 and 2 make use of the Next Steps cohort study with linked administrative data. The first chapter examines the impact of faithfulness, a form of intrinsic religiosity, on a range of educational and other outcomes. Once the Oster (2019) sensitivity test is applied, faithfulness is robustly and positively associated with educational attainment at GCSE and with Christian affiliation at age 25 but with no other outcomes. Faith schooling does not have any robust impacts other than a positive association with future Christian affiliation. The popular perception that faith schools are important for outcomes, therefore, appears to be misplaced – faith matters more. The second chapter examines the impact of the Education Maintenance Allowance (EMA) on a range of outcomes covering educational attainment, risky behaviours, and employment. Positive impacts are found on retention in further education and on university attendance; negative effects are found on the chance of being on an insecure employment contract at age 25. These estimates are causal under assumptions of unconfoundedness as they are estimated using Inverse Probability Weighting Regression Adjustment (IPWRA). Treatment heterogeneity is analysed using a machine learning approach called Causal Forests, with some interesting dimensions of heterogeneity identified. Chapter 3 uses the secure access version of the Labour Force Survey to analyse the effect of education on national identity. Education is instrumented using the Raising of the School Leaving Age (RoSLA) reform. Although OLS results suggest positive and significant effects on national identity, IV estimates are mixed, with signs turning negative and significance disappearing on one of the two outcomes, despite the instrument being very strong. Each of these topics has meaningful policy implications.
Studying fluid status and the dying: The challenge of clinical research in palliative care.
Creators: name: Viola, Raymond A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Health Sciences, Medicine and Surgery.

description: The investigation of the effects of fluid status and fluid therapy on the dying illustrates some of the obstacles to doing palliative care clinical research. Fluid status and fluid therapy. Objectives. Investigate the effects of fluid status and fluid therapy on the dying. Setting. Two inpatient palliative care units (PCUs), one in Ottawa (Ott) and one in Edmonton (Edm). 123 patients were approached for participation and 94 consented. These were followed in Phase I until 70 were at clinical risk of developing a fluid deficit and started the main phase of the study. (Phase II). Hypodermoclysis was given to all patients in Edm to maintain optimal fluid balance. No parenteral fluids were administered to Ott patients. Patients remained in Phase II until their risk of fluid deficit resolved for 10 days. The groups showed differences in indicators of fluid status, with poorer fluid status, the Ott group. The groups displayed differences at the start of Phase II in several symptom-related outcomes. Median survival in Ott from the start of Phase II was four days, and in Edm was 31.5 days. Both groups showed deterioration in cognitive status close to death. Myoclonus was more prevalent in Ott as were pressure ulcers, but there were no differences in level of consciousness or prevalence of edema. Drugs with sedating effects and with anticholinergic effects were used more often in Ott, while corticosteroids and oxygen were used more in Edm. Clinical research obstacles which are particularly relevant to palliative care and strategies for dealing with them were identified. Sixty-nine studies were identified. Eight included comparison groups and six of these were randomized trials. Obstacles were classified into four main categories: problems caused by the patients' poor and unstable conditions; ethical concerns; population heterogeneity; and lack of relevant outcome measures. (Abstract shortened by UMI.)
The effect of caveolin-1 on the synthesis and efflux of cholesterol in hepatoma cells and hepatocytes
Creators: name: McKenzie, Andrea
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Cell.

description: The effect of caveolin-1 on synthesis and efflux of cholesterol was studied using three cell systems. The McA-RH7777 cells were stably transfected with caveolin-1 previously. HepG2 cells were infected with a caveolin-1 adenovirus, and primary hepatocytes were isolated from homozygous and heterozygous caveolin-1 deficient and control mice. Overexpression of caveolin-1 resulted in an increase of cholesterol synthesis, and the absence of caveolin-1 resulted in a decrease in cholesterol synthesis. Cholesterol ester and phospholipid synthesis are not affected. The influence of caveolin-1 on efflux to HDL was small in the three cell models. Efflux of cholesterol to apoA-I was not significantly affected by caveolin-1 over expression. Caveolin-1 deficient hepatocytes had reduced cholesterol synthesis. Cholesterol efflux to HDL and exogenously added apoA-I decreased in the absence of apoA-I. Phospholipid and cholesterol lipidation of endogenously synthesized apoA-I was reduced in the absence of caveolin-1. Overall, caveolin-1 deficiency had more consistent effect on cholesterol metabolism than over expression of caveolin-1, suggesting that the basal level of caveolin-1 in hepatocytes is probably sufficient to regulate cholesterol homeostasis and cellular transport.
Ultra-fast broadband in New Zealand: Early adoption experience
Creators: name: MacMahon, Rohan
name: Milner, Murray
Publisher: name: Swinburne
Year: 2024

description: The New Zealand Government Ultrafast Broadband Initiative has been in progress now for a little over two years. Are its intended goals being achieved? As at December 2012, the rollout
is essentially on schedule, even though there have been some challenges. In particular, the Government specified that most priority customers within the candidate areas should be addressed by the end of 2015 and this appears to be on track. Take-up of services by these customers is also progressing well. The paper provides a brief review of three of the ways the
UFB is being used to enhance the outcomes for business, education and healthcare. Residential coverage is also progressing, but the take-up is low at this point of time as suitable
services are only just emerging from the Retail Service Provider community. Overall it is assessed that the 10 year programme of work is delivering on expectations at this point in
time, but there is still a long way to go and there are likely to be many challenges and perhaps a few surprises ahead.
On finding the eigenvalues of the matrix of rotation symmetric Boolean functions and generalizations using character theory
Creators: name: Albrizzio, Manuel
Publisher: name: University of Iowa
Year: 2023
Subjects: Boolean Function
Character Theory
Representation Theory
Rotation Symmetric Boolean Function
public abstract
Cryptography

description: Digital signatures are an important feature in any encryption/decryption scheme, providing a message with integrity, authenticity, and nonrepudiation. The problem occurswhen long messages are being exchanged with equally long signatures. By using hash functions, a ”fingerprint” of the message can be used along with the message for verification, making the process computationally inexpensive. Considering a single iteration of a general hashing algorithm, we see Rotation Symmetric Boolean Functions (RSBFs) allow for more efficient evaluation. This is when RSBFs were studied more deeply. This thesis focuses on a matrix that comes up when investigating these functions. We not only answer an open question about this matrix, but we also generalize this matrix using another area of mathematics, Representation Theory.
Studies of the measurement of differential luminosity using Bhabha events at the International Linear Collider
Creators: name: Sailer, Andre Philippe
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2009
Subjects: thesis
electron positron: linear collider
electron positron: elastic scattering
luminosity: measurement methods
parametrization
beam: energy spectrum
numerical calculations: Monte Carlo
ILC Coll
200-500 GeV-cms

description: Humboldt Universität Berlin, Diplomarbeit, 2009; 89 pp., (2009). doi:10.3204/DESY-THESIS-2009-011
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Biomechanical comparison of stair and ramp descent
Creators: name: Post, Andrew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Health Sciences, Recreation.

description: The purpose of this project was to quantify and analyze the changes that occur to the moments of force and moment powers at the joints of the lower extremity during stair and ramp descent. Methods. A sample population of five male and five female volunteers were asked to walk five times down a 10-degree ramp at normal gait speed, followed by five stair descent trials. Results and discussion. Stair descent has a larger eccentric plantar flexor peak at the ankle joint during weight acceptance. The knee exhibits slightly larger eccentric knee extensor peaks during ramp descent at push - off and there was higher loading of the hip during ramp descent as compared with stair descent. The higher ankle powers at FS during stair descent reveal a concern for those people suffering from ankle pathology and the larger hip and knee peaks during ramp descent is of concern to those with hip and knee problems. These results could be used in the rehabilitative considerations of patients with hip, knee and ankle replacements and as a baseline for future research. (Abstract shortened by UMI.)
Innenentwicklung organisieren
Creators: name: Ferber, Uwe
name: Tomerius, Stephan
name: Schrenk, Volker
Publisher: name: My University
Year: 2015
Subjects: subject: Kommunalpolitik
subject: Flächenressourcenmanagement
subject: Nachhaltige Entwicklung
subject: Brachflächenreaktivierung
subject: Zukunftsfähige Entwicklung
subject: Flächenrecycling
subject: Nachhaltige Stadtentwicklung
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: Die Innenentwicklung und das Flächenrecycling in Städten und Gemeinden sind wesentliche Instrumente, um die Zunahme der Siedlungs- und Verkehrsfläche zu begrenzen und die Zersiedelung von Landschaft und Natur zu stoppen. Der Ratgeber enthält Anregungen, wie Prozesse und behördlicher Verwaltungsablauf beim kommunalen Flächenmanagement optimal darauf ausgerichtet werden können. Eine Checkliste soll helfen, spezifische Ansätze dafür besser zu erkennen.
Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria
Creators: name: Conroy, Andrea L
name: Hawkes, Michael T
name: Elphinstone, Robyn
name: Opoka, Robert O
name: Namasopo, Sophie
name: Miller, Christopher
name: John, Chandy C
name: Kain, Kevin C
Publisher: name: BioMed Central
Year: 2018

description: Background: Chitinase-3-like 1 (CHI3L1) is a glycoprotein elevated in paediatric severe malaria, and an emerging urinary biomarker of acute kidney injury (AKI). Based on the hypothesis that elevated CHI3L1 levels in malaria are associated with disease severity, the relationship between plasma CHI3L1 levels, AKI and mortality was investigated in Ugandan children enrolled in a clinical trial evaluating inhaled nitric oxide (iNO) as an adjunctive therapy for severe malaria. Methods: Plasma CHI3L1 levels were measured daily for 4 days in children admitted to hospital with severe malaria and at day 14 follow up. AKI was defined using the Kidney Disease: Improving Global Outcomes consensus criteria. This is a secondary analysis of a randomized double-blind placebo-controlled trial of iNO versus placebo as an adjunctive therapy for severe malaria. Inclusion criteria were: age 1–10 years, and selected criteria for severe malaria. Exclusion criteria included suspected bacterial meningitis, known chronic illness including renal disease, haemoglobinopathy, or severe malnutrition. iNO was administered by non-rebreather mask for up to 72 h at 80 ppm. Results: CHI3L1 was elevated in patients with AKI and remained higher over hospitalization (p < 0.0001). Admission CHI3L1 levels were elevated in children who died. By multivariable analysis logCHI3L1 levels were associated with increased risk of in-hospital death (relative risk, 95% CI 4.10, 1.32–12.75, p = 0.015) and all-cause 6 month mortality (3.21, 1.47–6.98, p = 0.003) following correction for iNO and AKI. Treatment with iNO was associated with delayed CHI3L1 recovery with a daily decline of 34% in the placebo group versus 29% in the iNO group (p = 0.012). CHI3L1 levels correlated with markers of inflammation (CRP, sTREM-1, CXCL10), endothelial activation (Ang-2, sICAM-1) and intravascular haemolysis (LDH, haem, haemopexin). Conclusions: CHI3L1 is a novel biomarker of malaria-associated AKI and an independent risk factor for mortality that is associated with well-established pathways of severe malaria pathogenesis including inflammation, endothelial activation, and haemolysis. Trial registration Clinicaltrials.gov, NCT01255215. Registered December 7th 2010
Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD
Creators: name: Yamasaki, Kei
name: Eeden, Stephan F. Van
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Lung macrophages (LMs) are essential immune effector cells that are pivotal in both innate and adaptive immune responses to inhaled foreign matter. They either reside within the airways and lung tissues (from early life) or are derived from blood monocytes. Similar to macrophages in other organs and tissues, LMs have natural plasticity and can change phenotype and function depending largely on the microenvironment they reside in. Phenotype changes in lung tissue macrophages have been implicated in chronic inflammatory responses and disease progression of various chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). LMs have a wide variety of functional properties that include phagocytosis (inorganic particulate matter and organic particles, such as viruses/bacteria/fungi), the processing of phagocytosed material, and the production of signaling mediators. Functioning as janitors of the airways, they also play a key role in removing dead and dying cells, as well as cell debris (efferocytic functions). We herein review changes in LM phenotypes during chronic lung disease, focusing on COPD, as well as changes in their functional properties as a result of such shifts. Targeting molecular pathways involved in LM phenotypic shifts could potentially allow for future targeted therapeutic interventions in several diseases, such as COPD.
Cinquantaine et passage spirituel : analyse du vécu spirituel de femmes de l'Outaouais.
Creators: name: Éthier, Lorraine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Religion, General.

description: Cette recherche-action traite de la spiritualite du mitan de la vie chez des femmes de la region de l'Outaouais. Partant du constat que la spiritualite se vit dans un contexte et s'articule a partir de l'experience, et partant d'une penurie d'ecrits concernant le specifique de la spiritualite des femmes, nous avons elabore une recherche avec des femmes. En suivant rigoureusement les etapes de la methode de l'analyse de contenu nous avons explore, a partir du discours des concernees, l'impact de cette etape developpementale au plan spirituel. Notre questionnement principal concerne la possibilite d'une transformation spirituelle, chez certaines femmes, apres le passage de la menopause. Ce passage de la menopause inscrit dans la biologie entrai ne-t-il des transformations au plan spirituel? Les ecrits concernant le specifique de l'experience spirituelle des femmes de la cinquantaine sont peu nombreux, particulierement en langue francaise. Notre recherche propose l'existence d'un passage spirituel intrinseque et concomitant au climatere. Ce passage spirituel se caracterise principalement par un retour a soi comme source de maturation spirituelle et mouvement d'integrite. La spiritualite des femmes a cette etape est davantage basee sur l'experience et de moins en moins orientee vers des preceptes exterieurs. Enfin, nos resultats confirment l'emergence de l'archetype de "La Vieille Femme Sage" comme une manifestation de ce phenomene, tel que le suggerent des auteures feministes americaines. Comme piste d'actualisation de symboles et de rites qui ne correspondent plus a la realite des femmes d'aujourd'hui, et en reponse aux souhaits exprimes par les participantes, nous proposons la creation de rituels de passage pour souligner, faciliter et honorer cette etape developpementale importante. Cette suggestion repond au besoin de construire un pont entre le transcendent et l'immanent, entre une spiritualite dogmatique et une experience spirituelle incarnee et engagee.
Converging on an NBN future: Content, connectivity, and control – a symposium overview
Creators: name: Middleton, Catherine
name: Park, Sora
name: Allen, Matthew
Publisher: name: Swinburne
Year: 2024

description: This paper provides an overview of presentations and discussion at the October 2012 "Converging on an NBN Future" symposium held at the University of Canberra. Key themes
explored in the paper include recognition of the importance of Australia’s National Broadband Network as an enabler of the digital economy (noting the importance of network ubiquity and reliability as well as speed) and its central role as platform for innovation and new service delivery. The paper outlines challenges in selling the NBN and notes the need for increased
digital literacy across society, industry and governments. Policy issues arising in developing next generation communications infrastructure and services are discussed. The paper
concludes with symposium participants’ recommendations for advancing the NBN.
title: Das Denkmal als Lebensraum.
title: Sanierung einer denkmalgeschützten, anthropogen umweltgeschädigten Gräfte als Ausgangspunkt für die Bewahrung der Biodiversität der Auengewässer (FFH-Gebiet)
titleType: Subtitle
Creators: name: Hehmann, Friedrich
name: Lorenz, Kay
name: Dürkop, Detlef
name: Dense, Carsten
name: Fischer, Elmar
Publisher: name: Büro für Gewässerökologie, Fischereiliche Studien und Landschaftsplanung, Osnabrück
Year: 2011
Subjects: Ecology/conservation

description: Ziel ist die Entwicklung eines modellhaften Handlungsansatzes zur nachhaltigen Sanierung historisch wertvoller wassergeprägter Baudenkmäler unter Berücksichtigung des aktuellen Standes anwendungsorientierter ökologischer Forschung zur Sicherung und Entwicklung von floristisch / faunistisch bedeutsamen Natursteinmauern sowie wertvoller Ersatzlebensräume für auengewässertypische Organismen.
Für das Modellvorhaben wurde die Gräfte (Grabenanlage) am Gut Sutthausen bei Osnabrück gewählt, da hier die besondere Konstellation der auf relativ kleinem Raum vielfältig differenzierten Land, Wasser und Übergangslebensraumtypen bei der Umsetzung eines entsprechend ausgerichteten Sanierungskonzeptes erhebliche naturschutzfachliche Entwicklungspotentiale eröffnet: So bestehen im Bereich der Gräfte gute Voraussetzungen für eine nachhaltige Ansiedlung gefährdeter und vom Aussterben bedrohter Fischarten der Auengewässer. Aber auch schon heute besitzt die Gräfte einen hohen naturschutzfachlichen Wert als Lebensraum für seltene und gefährdete Tier und Pflanzenarten.
Dass die Gräfte teilweise umfassende Mauerwerk ist in wesentlichen Teilen sanierungsbedürftig. Infolge physikalischer und chemischer Verwitterungsprozesse haben sich an der wasserseitigen Basis der Mauern vielerorts deutlich sichtbare Schäden ergeben. Das oberhalb der Wasserlinie gelegene Mauerwerk ist durch gewässerseitig auswachsende Gehölze und landseitig eingedrungenes Wurzelwerk von Bäumen vielerorts geschädigt. Durch fortgesetzten Eintrag von Laub und infolge hoher interner Primärproduktion weist die Gräfte zudem in weiten Bereichen ihrer Sohle starke Verschlammungen auf. Seit einigen Jahren fällt sie deshalb im Sommer partiell auch trocken.
Counselors-in-training, traumatic experiences, counseling self-efficacy, and the supervisory working alliance
Creators: name: Li, Huijuan
Publisher: name: University of Iowa
Year: 2024
Subjects: counseling self-efficacy
counselor training
counselors in training
supervision
Counseling
Trauma

description: Considering the pervasive impact of trauma, counselors-in-training (CITs) often support clients who have endured traumatic experiences, potentially facing trauma themselves. This study examined how CITs’ counseling self-efficacy (CSE) was influenced by their interaction with trauma-related issues. A sample of 62 CITs from diverse backgrounds and counseling specialties participated in the survey. The findings revealed a significant positive correlation between CITs’ CSE and their supervisory working alliance (SWA). Conversely, vicarious trauma (VT) exhibited a significant negative relationship with CSE. Furthermore, employing hierarchical regression modeling, the study suggested that SWA and resilience might serve as protective factors for CITs’ self-efficacy, particularly in light of their exposure to traumatic events and experiences with VT. In addition, two open-ended questions were analyzed using inductive content analysis (ICA) to gain a richer understanding of CITs’ needs in supervision regarding trauma-related issues. The study concluded by discussing implications, limitations, and suggestions for future research endeavors.