cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DECIPHERING THE ROLE OF ⍺-N-TERMINAL METHYLATION IN MODULATING YEAST PROTEIN FUNCTION INCLUDING THE MULTITASKING STRESS RESPONSE PROTEIN, HSP31
Creators: name: Chen, Panyue
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Plant cell and molecular biology
Animal cell and molecular biology

description: Protein methylation is one of the most common protein posttranslational modifications (PTMs), within which protein α-N-terminal methylation is largely underexplored. Protein α-N-terminal methylation has been implicated in disease development, including cancer and neurodegenerative diseases, but the physiological and pathological roles of this PTM is not well understood. Protein α-N-terminal methylation modifies the free α-amino group on the protein N-termini and adds between one and three methyl groups by α-N-terminal methyltransferases. It has been shown that protein α-N-terminal methylation is conserved across prokaryotes and eukaryotes. The identification and characterization of the two α-N-terminal methyltransferases in humans, NTMT1 and NTMT2, and their homolog in yeast, Tae1, shows a high conserved substrate recognition and possible shared biological roles. α-N-terminal methyltransferases in humans and yeast recognize substrates with a canonical N-terminal motif, X1-P2-[K/R]3 (X=A, S, P or G after the initial M is cleaved). However, most of the proteins containing the canonical motif have not been studied and identified as substrates. In this study, we use a yeast as a model to explore the substrate members in the protein α-N-terminal methylome and understand the potential regulatory mechanisms. We characterized the yeast phenotypes associated with a TAE1 deletion strain, including increased resistance to heat stress, oxidative stress and paromomycin, and increased sensitivity to benomyl. We also extended the substrate repertoire by validating the presence of α-N-terminal methylation on six substrates by mass spectrometry. Furthermore, we investigate how α-N-terminal methylation could regulate Hsp31, a multifunctional heat shock protein that is associated with yeast heat response and oxidative response. Results suggest that methylation might regulate the localization of Hsp31, rather than directly regulating Hsp31 chaperone activity or methylglyoxalase activity. Alternatively, we developed another methodology to explore the α-N-terminal methylome without motif restriction by repurposing public mass spectrometry datasets for α-N-terminal methylation events in both yeast and humans. We found about 1-2 % of the total proteome are α-N-terminally methylated. Interestingly, the majority of the α-N-terminal methylation events were not on the canonical motif sequence. This indicates a more prevalent existence of α-N-terminal methylation.
Additional file 1 of Genome-wide identification and characterization of members of the LEA gene family in Panax notoginseng and their transcriptional responses to dehydration of recalcitrant seeds
Creators: name: Jia, Jin-Shan
name: Ge, Na
name: Wang, Qing-Yan
name: Zhao, Li-Ting
name: Chen, Cui
name: Chen, Jun-Wen
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1:Figure S1. The neighbor-joining (NJ) phylogenetic tree of PnoLEA proteins. PnoLEA genes families are grouped by different colors. The tree was constructed with amino acid sequences of identified PnoLEA genes and bootstrap value of 1000 replicates.
DESIGN AND COMMISSIONING OF A TEST STAND TO CONDUCT PERFORMANCE DEGRADATION STUDIES AND ACCELERATED LIFE TESTING ON WATER-COOLED VARIABLE-SPEED SCREW COMPRESSOR CHILLERS
Creators: name: Hoess, Andreas Josef
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Mechanical engineering not elsewhere classified

description: Environmental challenges, increasing energy costs and demand, and upcoming regulations (e.g., new equipment performance ratings, phase-down of HFCs) are a few of the main drivers behind the research on advanced HVAC&R equipment. The HVAC&R systems are one of the largest energy consumers in both commercial and residential buildings and their operation is essential to ensure thermal comfort as well as other industrial needs. Within this context, large chillers provide chilled water to condition commercial buildings and the new generation of smart chillers feature variable speed compressors that enable active capacity modulation. In turn, variable speed operation along with other factors can contribute to performance degradation. Understanding mechanisms of degradation and developing models that enable predicting the decrease in performance with respect to the rated values are still open topics in the literature. The overarching goal of this research is to investigate the performance degradation of a water-cooled variable-speed screw chiller under long term operation and to gain insights on the behavior of the chiller under accelerated life testing. In particular, this thesis covers the initial task of designing an experimental test setup that enables performance testing according to the AHRI 550/590 standard. Once the experimental setup was commissioned, a set of four standard-conform baseline tests was conducted to map the rated performance of the chiller at both full and part-load conditions. After completing the baseline tests, an accelerated life test cycle procedure was developed and implemented in order to conduct 24/7 automated testing on the chiller. To this end, two test modes were established to simulate a real-life use of the chiller and induce high level of thermo-mechanical stresses on the compressor. Furthermore, eight recurring baseline tests were conducted to determine the performance behavior after 1000 operating hours. Finally, a preliminary system model was set up. This thesis describes the design of the system, the commissioning and control and provides insights on the performance testing as well as long-term testing methodology and the modeling work that was done so far.
sj-pdf-3-neu-10.1177_19714009211047455 - Supplemental material for Correlation of dual energy computed tomography electron density measurements with cerebral glioma grade
Creators: name: Chakrabarti, Ritwik
name: Gupta, Vivek
name: Vyas, Sameer
name: Gupta, Kirti
name: Singh, Vikram
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-pdf-3-neu-10.1177_19714009211047455 for Correlation of dual energy computed tomography electron density measurements with cerebral glioma grade by Ritwik Chakrabarti, Vivek Gupta, Sameer Vyas, Kirti Gupta and Vikram Singh in The Neuroradiology Journal
Additional file 3 of Genome-wide identification and characterization of members of the LEA gene family in Panax notoginseng and their transcriptional responses to dehydration of recalcitrant seeds
Creators: name: Jia, Jin-Shan
name: Ge, Na
name: Wang, Qing-Yan
name: Zhao, Li-Ting
name: Chen, Cui
name: Chen, Jun-Wen
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3:Figure S2. Collinearity map of the PnoLEA genes in P. notoginseng to other four species. The blue lines denote collinearity between the PnoLEA genes and other species, while the gray lines represent collinearity between the P. notoginseng genome and other species.
Contributions to the theory of Gaussian Measures and Processes with Applications
Creators: name: Selk, Zachary A
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Probability theory
Optimisation
Stochastic analysis and modelling

description: This thesis studies infinite dimensional Gaussian measures on Banach spaces. Let $\mu_0$ be a centered Gaussian measure on Banach space $\mathcal B$, and $\mu^\ast$ is a measure equivalent to $\mu_0$. We are interested in approximating, in sense of relative entropy (or KL divergence) the quantity $\frac{d\mu^z}{d\mu^\ast}$ where $\mu^z$ is a mean shift measure of $\mu_0$ by an element $z$ in the so-called ``Cameron-Martin" space $\mathcal H_{\mu_0}$. That is, we want to find the information projection
 $$\inf_{z\in \mathcal H_{\mu_0}} D_{KL}(\mu^z||\mu_0)=\inf_{z\in \mathcal H_{\mu_0}} E_{\mu^z} \left(\log \left(\frac{d\mu^z}{d\mu^\ast}\right)\right).$$
 We relate this information projection to a mode computation, to an ``open loop" control problem, and to a variational formulation leading to an Euler-Lagrange equation. Furthermore, we use this relationship to establish a kind of Feynman-Kac theorem for systems of ordinary differential equations. We demonstrate that the solution to a system of second order linear ordinary differential equations is the mode of a diffusion, analogous to the result of Feynman-Kac for parabolic partial differential equations.
Observing the northern limb of the Atlantic Meridional Overturning Circulation (AMOC) - OBPS workshop
Creators: name: Hátún, Hjálmar
Publisher: name: Zenodo
Year: 2024

description: Presentation delivered at Ocean Best Practices Workshop, online, on 17 October 2024. Part of the session "Ocean-Climate Nexus - Importance of Ocean Observing for Tipping Points, and the downstream effects of Tipping Points." organized jointly by TipESM, OCEAN:ICE, ClimTip and ObsSea4Clim EU Horizon projects.
Ready or Not: A Narrative Study Examining the Preparation Experiences of Black Women Engineers for the Raced and Gendered Engineering Workplace
Creators: name: Brown, Harriet Paige Lewt
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Other engineering not elsewhere classified

description: Black women make up 1.3% of undergraduate engineering students, 1% of bachelor’s engineering degrees awarded, and 0.6% of employed engineers. The magnitude of underrepresentation of Black women is strongly evident given the juxtaposition between these statistics and the percentage of Black women within the U.S. population. This underrepresentation of Black women in engineering exemplifies serious equity concerns involving the quality of women’s experiences in education and employment systems. The issues related to representation and retention in engineering among Black women signify that professional engineering environments that can be characterized by raced and gendered practices; practices that should be changed if engineering desires to be a more inclusive space for Black women. This reality brings up the question of whether undergraduate engineering education programs prepare Black women for the workplace and the extent to which their preparation process accounts for the raced and gendered challenges. This study examines the undergraduate preparation experiences of ten Black women engineers, exploring the challenges they have experienced that are associated with the raced and gendered culture of the engineering workplace. The goal of this study is to consider how undergraduate engineering education can better meet the needs of Black women so that they can successfully navigate the raced and gendered culture of engineering. Grounded in critical race feminism, this study leveraged narrative inquiry and counter-storytelling to address the following research question: How do Black women engineers describe their preparation to navigate the challenges in the engineering workplace associated with the raced and gendered culture of engineering? Findings from this study indicate that the formal curriculum of undergraduate engineering programs did not prepare Black women engineers for the raced and gendered culture of engineering. However, co-curricular activities, situated learning experiences, faith and spirituality, knowledge gained from graduate coursework, and the subsequent community cultural wealth gained from those experiences were instrumental in the preparation of Black women engineers for the raced and gendered culture of engineering. Two major implications of this work prompt the need for an ecosystems approach to change the culture of engineering and a formal preparation process for the raced and gendered culture of engineering.
sj-docx-5-rse-10.1177_07419325211047956 – Supplemental material for Examining the Likelihood of Parents’ Homework Involvement With Elementary-Aged Students With Individualized Education Plans
Creators: name: Womack, Tyler A.
name: Johnson, Austin H.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-5-rse-10.1177_07419325211047956 for Examining the Likelihood of Parents’ Homework Involvement With Elementary-Aged Students With Individualized Education Plans by Tyler A. Womack and Austin H. Johnson in Remedial and Special Education
Additional file 1 of Walkability and urban built environments—a systematic review of health impact assessments (HIA)
Creators: name: Westenhöfer, Joachim
name: Nouri, Elham
name: Reschke, Merle Linn
name: Seebach, Fabian
name: Buchcik, Johanna
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Additional file 1: Table S1. Geographic distribution of HIAs. Table S2. Types of projects, programs or policies that is evaluated using HIA. Table S3. Type of HIA. Table S4. Type of health endpoints. Table S5. Type of data source for the HIA. Table S6. Type of results.
SCALABLE NANO-MANUFACTURING OF INK-BASED HUMAN INTEGRATED ENERGY HARVESTING DEVICES
Creators: name: Perera, Hettiarachchige D
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Nanomanufacturing

description: This masters thesis presents a literature review of widely used ink-based manufacturing techniques, ink-based materials used in energy harvesting. their preparation and applications in human-integrated energy harvesting devices. In addition, the challenges, and opportunities in this area of study is discussed. Lastly, the experimental methodology and results of a stencil printed PVA-gelatin composite ink based flexible triboelectric nanogenerator used for human-integrated energy harvesting is summarized.
Material docente-ilustrativo audiovisual: Ingles para Animación Turística
Creators: name: Neolaidis González Cintra
name: Nuria Garcia Rodriguez
Publisher: name: Zenodo
Year: 2025

description: Este material docente metodológico se enmarcó entre los llamados Materiales ilustrativos audiovisuales. El uso de este material en la impartición del inglés con fines específicos para la especialidad de animación turística permitirá en su resultado final que el estudiante se sienta más interesado en aprender todo lo relacionado con la especialidad. El mismo contiene imágenes, videos y audios vinculados a los temas a tratar en cada unidad logrando de esta forma un acercamiento en la enseñanza del inglés para la especialidad de animación turística. Problema:  inexistencia de un material ilustrativo-audiovisual relacionado con la especialidad de animación turística en el centro. Objetivo: complementar las clases diseñadas para el curso Ingles para animación turística y/o para ser usado por los estudiantes como material de apoyo para su auto-aprendizaje. Impacto: se observó una gran motivación por parte de los estudiantes y un acercamiento a modelos auténticos lo que conllevó a una adecuada preparación para mejorar su desempeño acorde con las competencias exigidas por el plan de estudio. Métodos y técnicas utilizadas: consulta de varios sitios web dedicados a la enseñanza con fines específicos, recopilación y edición de videos relacionados con la especialidad, consulta a especialistas. Resultado: se logró un material ilustrativo-audiovisual con ejercicios metodológicamente gradados que complementan la preparación de la asignatura Ingles para la especialidad de animación turística.

Palabras claves: material, audiovisual, inglés, animación
Additional file 1 of How the Plants for Joints multidisciplinary lifestyle intervention achieved its effects: a mixed methods process evaluation
Creators: name: Wagenaar, Carlijn A.
name: Toonstra, Alie
name: Walrabenstein, Wendy
name: van Schaardenburg, Dirkjan
name: van Nassau, Femke
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1. Plants for Joints Intervention. Overview of Plants for Joints intervention including content of group meetings and program timeline.
KORXONANING INNOVATSION FAOLIYATINI BOSHQARISH TIZIMIGA TA'SIR ETUVCHI OMILLARNI BAHOLASH
Creators: name: Akramboyev, Azizbek
Publisher: name: Zenodo
Year: 2025

description: Korxonaning innovatsion faoliyatini boshqarish tizimiga ta’sir etuvchi omillarni o‘rganish, har bir korxonaga innovatsiyalarni boshqarish tizimini rivojlantirishdagi omillarni guruhlarga ajratish.
Additional file 2 of How the Plants for Joints multidisciplinary lifestyle intervention achieved its effects: a mixed methods process evaluation
Creators: name: Wagenaar, Carlijn A.
name: Toonstra, Alie
name: Walrabenstein, Wendy
name: van Schaardenburg, Dirkjan
name: van Nassau, Femke
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 2. Process evaluation questionnaire. English translation (from Dutch) of the process evaluation questionnaire for Plants for Joints participants.
sj-pdf-1-qhr-10.1177_10497323211043493 – Supplemental material for An Overwhelming Burden of Psychosocial Stress: Life With Ischemic Heart Disease for Midlife Patients With Low Socioeconomic Status and Lack of Flexible Resources
Creators: name: Rasmussen, Amanda Nikolajew
name: Petersen, Kirsten Schultz
name: Overgaard, Charlotte
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-qhr-10.1177_10497323211043493 for An Overwhelming Burden of Psychosocial Stress: Life With Ischemic Heart Disease for Midlife Patients With Low Socioeconomic Status and Lack of Flexible Resources by Amanda Nikolajew Rasmussen, Kirsten Schultz Petersen and Charlotte Overgaard in Qualitative Health Research
Supplemental Material, sj-docx-1-cll-10.1177_09636897211041587 - Therapeutic and Systemic Adverse Events of Immune Checkpoint Inhibitors Targeting the PD-1/PD-L1 axis for Clinical Management of NSCLC
Creators: name: Chen, Jing
name: Alduais, Yaser
name: Chen, Baoan
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine
Cell Biology

description: Supplemental Material, sj-docx-1-cll-10.1177_09636897211041587 for Therapeutic and Systemic Adverse Events of Immune Checkpoint Inhibitors Targeting the PD-1/PD-L1 axis for Clinical Management of NSCLC by Jing Chen, Yaser Alduais and Baoan Chen in Cell Transplantation
title: Ekkehard Felder (Hg.). 2013. Faktizitätsherstellung in Diskursen. Die Macht des Deklarativen
Creators: name: Kalwa, Nina
Publisher: name: De Gruyter
Year: 2025

description: Seit dem Jahr 2005 besteht das Forschungsnetzwerk Sprache und Wissen, dessen Mitglieder Wissenschaftlerinnen und Wissenschaftler verschiedener Disziplinen sind, die sich für das Verhältnis von Sprache und Wissen interessieren und dieses aktiv beforschen. Dem Netzwerk „liegt die Sprachauffassung zugrunde, dass jede Erkenntnis auch sprachabhängig ist“ (Felder 2008: 270). Dass Sprache die Wirklichkeit nicht bloß abbildet, sondern häufig erst konstituiert, dass „die gesamtgesellschaftlich relevanten Wissensbestände durch die eingesetzten sprachlichen Mittel (mit)geformt“ (Felder 2008: 270) werden, ist eine Prämisse, die inzwischen vielen diskurslinguistischen Arbeiten zugrunde liegt (z. B. Radeiski 2011, Spieß 2011, Vogel 2012, Kalwa 2013). Der von Ekkehard Felder herausgegebene Sammelband fragt, „wie kommunikativ in Sprache erst hergestellt wird, was schon da zu sein scheint“ (S. V).
Modulating ATP synthase activity as a therapeutic strategy for mitochondrial diseases
Creators: name: Patrick, Labenyimoh
Publisher: name: No Publisher Supplied
Year: 2025

description: Mitochondrial dysfunction due to mutations in the MT-atp6 gene is a key factor in diseases like Leigh syndrome, characterized by impaired ATP production. Our study aims to investigates the potential of a C-terminal extension from M. solifigus ATP6 to rescue mitochondrial function in a Leigh syndrome cell model harboring the m8993T>G mutation. We use a cybrid cell line, GM16530, derived from the fusion of enucleated B-lymphocytes from a Leigh syndrome patient with the 143BTK- osteosarcoma cell line, which is depleted of mtDNA. We have created a plasmid containing the C-terminal extension fused to human ATP6 and will employ mitochondrial targeting sequences from COX10 or LOC100282174 to facilitate mitochondrial translocation. Following transient transfection of this construct into the cybrid cell line, we will assess mitochondrial localization using immunofluorescence and evaluate functionality by comparing cell growth on glucose (glycolysis) versus galactose (OXPHOS) media. To further evaluate the extension's effectiveness, we will generate stable cell lines via retroviral infection and assess growth rates and mitochondrial function. Key assays will include ATP detection, and oxygen consumption measurements using the Seahorse XF Extracellular Flux Analyzer.
Additional file 3 of How the Plants for Joints multidisciplinary lifestyle intervention achieved its effects: a mixed methods process evaluation
Creators: name: Wagenaar, Carlijn A.
name: Toonstra, Alie
name: Walrabenstein, Wendy
name: van Schaardenburg, Dirkjan
name: van Nassau, Femke
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 3. Focus group guide. Guide used for process evaluation focus groups with participants.
Additional file 4 of How the Plants for Joints multidisciplinary lifestyle intervention achieved its effects: a mixed methods process evaluation
Creators: name: Wagenaar, Carlijn A.
name: Toonstra, Alie
name: Walrabenstein, Wendy
name: van Schaardenburg, Dirkjan
name: van Nassau, Femke
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 4. Interview guide. Guide used for process evaluation interviews with coaches.
sj-docx-2-pie-10.1177_09544089211045907 - Supplemental material for Numerical modelling of activation energy and hydromagnetic non-Newtonian fluid particle deposition flow in a rotating disc
Creators: name: Babu, B. Hari
name: Rao, P. Srinivasa
name: Reddy, M. Gnaneswara
name: Varma, S.V.K.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-2-pie-10.1177_09544089211045907 for Numerical modelling of activation energy and hydromagnetic non-Newtonian fluid particle deposition flow in a rotating disc by B. Hari Babu, P. Srinivasa Rao, M. Gnaneswara Reddy and S.V.K. Varma in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
UNRAVELING CYCLIC DINUCLEOTIDE SIGNALING IN IMMUNE CELLS AND DISCOVERY OF NOVEL ANTIBACTERIAL AGENTS
Creators: name: Onyedibe, Kenneth Ikenna
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Immunology not elsewhere classified
Infectious diseases
Bioinformatics and computational biology not elsewhere classified
Microbiology not elsewhere classified
Proteomics and intermolecular interactions (excl. medical proteomics)

description: Cyclic dinucleotides (CDNs) such as the bacterial CDNs (cyclic-di-AMP, cyclic-di-GMP and 3’3’cyclic GMP-AMP) and mammalian CDN, 2’3’-cGAMP, are essential immune response second messenger signaling molecules. These CDNs act via Stimulator of interferon genes (STING)-TANK Binding Kinase 1 (TBK1)-Interferon Regulatory Factor 3 (IRF3) pathway. However, data from our lab and others indicate that beyond the classical STING-TBK1-IRF3 pathway, CDNs also regulate other signaling axes related to both inflammatory and non-inflammatory pathways. But, a global view of how these CDNs affect signaling in diverse cells or through non-STING pathways is lacking. There is also paucity of data on CDN modulated kinases and no global assessment of phosphorylation events that follow cyclic GMP AMP synthase (cGAS)-STING axis stimulation in immune cells. Herein, I have used a proteomics approach to determine signaling pathways regulated by bacterial CDNs, c-di-GMP and c-di-AMP in human gingival fibroblasts such as pathways related to nucleotide excision repair (NER) which ordinarily do not channel through STING (Chapter 3). Additionally, with the use of phosphoproteomics and bioinformatics, this project accomplished a system-wide phosphorylation analyses of T cells treated with 2’3’cGAMP and showed that 2’3’cGAMP impact various, yet unreported critical kinases (E.g. LCK, ZAP70, ARG2) and signaling pathways important for T cell function (Chapter 4). Asides known interferon signaling, these differentially phosphorylated kinases were involved in T cell receptor (TCR) signaling, myeloid cell differentiation, cell cycle regulation, and regulation of double strand break repair. Another area of interest addressed by this project is the discovery of novel antibacterial agents against multi-drug resistant (MDR) bacteria. Thus, in Chapters 5 and 6, I show the identification, antibacterial activity and characterization of HSD1835 and HSD1919 as novel SF5 and SCF-containing membrane active compounds, highly potent against preformed MDR biofilms with fast bactericidal activity against persister bacteria. Plus, an exciting addition to the fight against MDR bacteria in Chapter 7, the discovery of HSD1624 and analogs, which are able to re-sensitize MDR and colistin resistant bacteria such as Pseudomonas aeruginosa from a colistin MIC of 1024 μg/mL to 0.03 μg/mL (64000-fold reduction). Ultimately, these compounds could be translated into anti-biofilm and, anti-MDR bacteria therapeutics, preventing repeated surgeries due to infections, and saving lives.
Capsella D5.2 Social Media Analysis Report
Creators: name: Pontiki, Maria
name: Pappas, Dimitris
name: Papageorgiou, Haris
Publisher: name: Zenodo
Year: 2016
Subjects: Social Media
Data Management
Sentiment Analysis

description: This deliverable provides details regarding the CAPSELLA social media analysis platform (the social media channels and the insights extracted for specific communities). The document will be updated on a regular basis reflecting the developments on the platform and the CAPSELLA pilots.
THE INTERPLAY BETWEEN CHRONIC RENAL FAILURE AND HYPOTHYROIDISM: EXPLORING A COMPLEX MEDICAL RELATIONSHIP
Creators: name: Dr. Rachel, Chen
name: Prof. David, Wang
Publisher: name: continental journal
Year: 2024
Subjects: Chronic renal failure, end-stage renal disease, thyroid-related diseases, treatment, metabolic disruptions

description: Chronic renal failure (CRF) is a complex condition characterized by metabolic disruptions, fluid and electrolyte imbalances, and systemic symptoms stemming from renal dysfunction caused by various primary or secondary chronic renal diseases. It progressively evolves into end-stage renal disease (ESRD), a common outcome of various chronic renal conditions. The long and generally ineffective treatment course for CRF, coupled with the high cost and potential complications associated with alternative therapies such as dialysis or renal transplantation, places substantial burdens on patients and society. These therapies can significantly impact disease prognosis and diminish the quality of life for affected individuals, underscoring the urgency of early and effective interventions.

Recent years have witnessed a growing focus on the link between thyroid-related disorders and kidney-related diseases. Understanding this connection holds promise for advancing the management and treatment of CRF. This study explores the intricate relationship between thyroid-related conditions and chronic renal failure, shedding light on potential avenues for more effective therapeutic approaches.
VISUAL EXPERIENCE ENHANCED FEATURE SELECTIVITY IN PRIMARY VISUAL CORTEX
Creators: name: Gao, Mang
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Neurosciences not elsewhere classified

description: The primary visual cortex (V1) is a center in the visual pathway that receives the converging information and sends diverging information to multiple visual areas. It is essential for the normal functioning of the visual system. While processing the input from the outside world, it is also continually modified by the sensory experience. This thesis is dedicated to studying the plasticity in the visual cortex that is associated with experience and brain damage recovery. In this thesis, we discovered that the visual experience induces 5 Hz oscillations that recruit inhibition in V1, sharpening the feature selectivity. We have also demonstrated that gene therapy to convert astrocytes into neurons induces neuronal circuit plasticity and functional recovery in mouse V1 following ischemia.
Capsella D5.3 Enhanced Ciard Ring With Capsella Data Sets & Global Map Of Challenges & Ideas For Solutions 1
Creators: name: Zervas, Panagiotis
name: Kastrantas, Kostas
name: Stoitsis, Giannis
name: Tsantilis, Vassilis
Publisher: name: Zenodo
Year: 2016
Subjects: open datasets
registering
challenges
ideas for solutions
voting mechanisms
CIARD-RING

description: This software deliverable presents the deployment of the online catalogues of challenges, needed data sources, ideas/prototypes of solutions and voting mechanisms.
Additional file 6 of How the Plants for Joints multidisciplinary lifestyle intervention achieved its effects: a mixed methods process evaluation
Creators: name: Wagenaar, Carlijn A.
name: Toonstra, Alie
name: Walrabenstein, Wendy
name: van Schaardenburg, Dirkjan
name: van Nassau, Femke
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 6: Supplementary figure 1. Results flow chart, Supplementary table 1. Mixed method results for participant recruitment via questionnaire and focus groups, Supplementary table 2. Mixed method results for participant’s motivation to join via questionnaire and focus groups, Supplementary table 3. Mixed method results for stimulation and usefulness of behavioral change techniques used by coaches according to participants and coaches, Supplementary table 4. Mixed method results for usage and perceived usefulness of offered tools and activities according to participants and coaches, Supplementary table 5. Mixed method results for satisfaction of the group sessions according to participants and coaches, Supplementary table 6. Mixed method results for group sessions perceived as most and least useful according to participants and coaches, Supplementary table 7. Mixed method results for group dynamic of live, hybrid, or online group sessions according to participants, Supplementary table 8. Mixed method results for effect of the Plants for Joints lifestyle intervention on lifestyle changes during the intervention and in the future according to participants.
Capsella D5.4 Enhanced Ciard Ring With Capsella Data Sets & Global Map Of Challenges & Ideas For Solutions 2
Creators: name: Zervas, Panagiotis
name: Tsantilis, Vasilios
name: Stoitsis, Giannis
name: Koukourikos, Antonios
name: Palavitsinis, Nikolaos
name: Konstanitinidis, Sotirios
Publisher: name: Zenodo
Year: 2017
Subjects: open datasets
registering
challenges
ideas for solutions
voting mechanisms
CIARD-RING

description: This software deliverable presents the deployment of the online catalogues of challenges, needed data sources, ideas/prototypes of solutions and voting mechanisms.
Characteristics of Self-Excited Wave Propagation in a Non-Premixed Linear Detonation Combustor
Creators: name: Jackson, Deborah Renae
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Aerospace engineering not elsewhere classified

description: The interaction and behavior of detonation waves propagating in a linear detonation combustor (LDC) were studied to identify the coupled thermoacoustic-chemical phenomenon responsible for self-generated and self-sustained detonation waves. The LDC was operated with natural gas and gaseous oxygen over a wide range of equivalence ratios and optically observed with OH*-chemiluminescence, schlieren, and broadband imaging in addition to high-frequency pressure transducers and photomultiplier tubes. Counter-propagating, self-sustained detonation waves were observed in the semi-bounded combustor to accelerate and amplify consistently from the closed-boundary to the open-boundary. The incident waves then reflect off of the open-boundary and transition into weaker waves that propagate acoustically relative to the burned products before being reflected by the closed-boundary and accelerating to dominancy once again. The combustor was then modified to have symmetric boundary conditions with both ends closed. For closed cases, the detonation waves experienced similar acceleration and amplification processes. The incident waves accelerate until they are reflected by a closed boundary into a flow field for which the fuel-injectors have yet to recover. For this reason, the reflected waves propagate through burned products until they encounter fresh reactants and accelerate again. The closed boundary conditions also caused the direction of dominance to periodically alternate. This study indicates that the local mixing field between open and closed boundary conditions affects the strength and speed of the reflected wave and demonstrates the impact of combustor geometry on coupled thermoacoustic-chemical phenomenon in RDEs.
MPEC 2025-F105 : 2025 FP4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 FP4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Association of neutrophil–lymphocyte ratio with survival in peripheral early-stage non-small cell lung cancer after stereotactic body radiation therapy
Creators: name: Huang, Karen
name: Prasad, Sharan
name: Ma, Sung Jun
name: Yu, Han
name: Iovoli, Austin J.
name: Farrugia, Mark K.
name: Dexter, Elizabeth U.
name: Demmy, Todd L.
name: Malik, Nadia K.
name: Singh, Anurag K.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: eTable 1. Fine-Gray multivariate analysis for nodal and distant failure recurrences. eTable 2. Characteristics of NSCLC patients after propensity score matching (n=214). eTable 3. Logistic regression of NSCLC patient cohort to identify related variables to NLR.
La ciencia de la sostenibilidad desde la interprofesionalidad en la conservación del espacio turístico patrimonial
Creators: name: Mabel Teresa Chaos Yeras
name: Raúl Alberto Morales Rivero
name: Jorge García Batán
name: Belkis Sóñora Álvarez
Publisher: name: Zenodo
Year: 2025

description: Las amenazas a la salud humana centraron las investigaciones en alcanzar una ciencia de la sostenibilidad como elemento indispensable para la supervivencia. Desde esta perspectiva, los procesos de formación profesional deben ser actualizados bajo el prisma de la educación interprofesional. Para ello se valoran las distintas implicaciones de la relación patrimonio-turismo, así como la necesidad de la toma de decisiones colegiadas y el trabajo en equipo. El objetivo del trabajo es proponer un conjunto de consideraciones para una futura estrategia sustentada en un modelo de formación interprofesional que propicie el cambio hacia un modo de actuación profesional para garantizar la conservación del espacio turístico patrimonial. Se utilizaron métodos teóricos como el análisis crítico de las fuentes para establecer las relaciones entre los conceptos abordados y el método analítico-sintético para integrar los resultados. La necesidad urgente de activar las economías a partir de la recesión económica global, ha obligado a repensar las problemáticas de las ciudades relacionadas con la conservación del espacio turístico patrimonial desde la ciencia de la sostenibilidad. La ciencia de la sostenibilidad lleva a promover un enfoque de pensamiento integrado, lo cual implica cambios profundos para lo cual cobran sentido conceptos como educación interprofesional (EIP), trabajo en equipo (TE) y toma de decisiones colegiadas (TDC). Ello se traduce en la necesidad de que la formación fomente el desarrollo de competencias para la conservación del espacio turístico patrimonial. Como resultado de los análisis realizados se obtienen consideraciones para una futura estrategia sustentada en un modelo de formación interprofesional.
Additional file 2 of Qualitative exploration of perspectives of the pharmacists working in public-sector hospitals during COVID-19 pandemic
Creators: name: Khadka, Sitaram
name: Saleem, Mohammad
name: Usman, Muhammad
name: Hashmi, Furqan K.
name: Tariq, Fatima
name: Zaheer, Warda
name: Imon, Sabahat
name: Inam, Aqsa
name: Gupta, Ravi Prasad
name: Aryal, Pallav
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2. COREQ checklist.
The Power Of Scheduling-Aware Synchronization
Creators: name: Fatourou, Panagiota
name: Kallimanis, Nikolaos D.
Publisher: name: Zenodo
Year: 2014
Subjects: synchronization
universal constructions

description: We present Hydra, a blocking synchronization protocol which signi cantly outperforms all previous state-of-the-art synchronization algorithms. We experimentally show that the throughput of Hydra is higher than that of CC-Synch, a state-of-the-art synchronization protocol presented in PPoPP '12, by a multiplicative factor of up to 7.9; this throughput is surprisingly close to the ideal. Hydra implements the combining technique. It also employs user-level threads and schedules them appropriately to ensure their synchronization, as well as to improve performance.

We show that by appropriately using user-level threads, we can also get a simple variant of PSim, called PSimX, with highly upgraded performance than that of PSim; PSim is a state-of-the-art wait-free universal construction, rst appeared in SPAA '11. The performance of PSimX, albeit lower than that of Hydra, is also very close to the ideal. Experiments show that by employing user-level threads in other state-of-the-art synchronization protocols, we do not get so big performance advantages as for Hydra and PSimX.

To evaluate the performance of Hydra and PSimX, we implement and experimentally evaluate implementations of concurrent queues and stacks, based on Hydra and PSimX. Our queue implementation outperforms by far all current state-of-the-art concurrent

queue implementations.

Based on our protocols, it is easy to implement useful primitives (like double CAS and others) at a surprisingly low cost.
description: This is a Technical Report at FORTH ICS: FORTH-ICS TR 442, JANUARY 2014
Oligomeric Collagen Encapsulation Design and Mechanism of Protection for Beta-cell Replacement Therapy
Creators: name: Morrison, Rachel Alena
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Biomedical engineering not elsewhere classified

description: Type 1 Diabetes Mellitus (T1D), a chronic disease affecting over 1.5 million Americans, is characterized by the autoimmune destruction of insulin-producing β-cells within pancreatic islets. Islet/β-cell replacement therapies, where replenishable β-cell sources are implanted within protective microenvironments, have the potential to provide a long-term solution for individuals with T1D by restoring glucose-sensitive, insulin release and overall glycemic control. However, most conventional encapsulation materials elicit an immune reaction, known as a foreign body response (FBR), which compromises β-cell health and function. In this dissertation, we designed and evaluated various formulations of a polymerizable collagen, namely type I oligomeric collagen (Oligomer), as encapsulation materials for minimally invasive, subcutaneous delivery of replacement β-cells. Preclinical validation in chemically-induced diabetic mice demonstrated rapid (within 24 hours) reversal of diabetes for beyond 90 days with no signs of rejection or FBR after subcutaneous delivery of both allogeneic and xenogeneic (rat) islets. To further define this uncommon mechanism of protection, the tissue response to Oligomer, in comparison to commercial synthetic and collagen-based materials, was evaluated following subcutaneous implantation within rats, a well-established biocompatibility model. Histological and transcriptomics analyses were used to define the immune response at both cellular and molecular levels. Interestingly, Oligomer showed minimal and transient activation of innate immune cells similar to the sham surgical control, with no evidence of foreign body giant cell formation, inflammatory-mediated bioresorption, or fibrosis. Overall, this work evaluates preclinical efficacy and demonstrates mechanistic understanding of immune tolerance for Oligomer materials for β-cell replacement therapy and other regenerative medicine applications.
Additional file 1 of Real-world evidence of treatment patterns and survival of metastatic gastric cancer patients in Germany
Creators: name: Luna, Jaime
name: Picker, Nils
name: Wilke, Thomas
name: Lutz, Magnus
name: Hess, Jürgen
name: Mörtl, Bernhard
name: Xiong, Yan
name: Götze, Thorsten Oliver
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
sj-pdf-5-neu-10.1177_19714009211047455 - Supplemental material for Correlation of dual energy computed tomography electron density measurements with cerebral glioma grade
Creators: name: Chakrabarti, Ritwik
name: Gupta, Vivek
name: Vyas, Sameer
name: Gupta, Kirti
name: Singh, Vikram
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-pdf-5-neu-10.1177_19714009211047455 for Correlation of dual energy computed tomography electron density measurements with cerebral glioma grade by Ritwik Chakrabarti, Vivek Gupta, Sameer Vyas, Kirti Gupta and Vikram Singh in The Neuroradiology Journal
Lernzielmatrix zum Themenbereich Forschungsdatenmanagement (FDM) für die Zielgruppen Studierende, PhDs und Data Stewards
Creators: name: Petersen, Britta
name: Engelhardt, Claudia
name: Hörner, Tanja
name: Jacob, Juliane
name: Kvetnaya, Tatiana
name: Mühlichen, Andreas
name: Schranzhofer, Hermann
name: Schulz, Sandra
name: Slowig, Benjamin
name: Trautwein-Bruns, Ute
name: Voigt, Anne
name: Wiljes, Cord
Publisher: name: Zenodo
Year: 2022
Subjects: Forschungsdatenmanagement
FDM
Datenkompetenz
RDM
Lernziel
Studium
Lehre
Data Steward
Fort- und Weiterbildung
Data Literacy
Schulung
Hochschullehre
Training
Curriculum
Kompetenz

description: Ein bedeutendes neues Handlungsfeld der Forschung, welches im Zuge der Digitalisierung entstanden ist, ist das Management von digitalen Forschungsdaten. Wissenschaftler*innen benötigen für ein nachhaltiges Forschungsdatenmanagement (FDM) neben Kenntnissen und Fähigkeiten im fachlichen Bereich zusätzliche Kompetenzen im Umgang mit digitalen Daten. Die Vermittlung dieser Kenntnisse sollte idealerweise bereits im Studium erfolgen. Zudem besteht ein steigender Bedarf an forschungsunterstützendem Personal, z.B. in Form von Data Stewards, der nur über geeignete Aus- und Weiterbildungsmaßnahmen gedeckt werden kann. Die vorliegende Lernzielmatrix fasst für das FDM relevante Vermittlungsinhalte sowie zugehörige Lernziele auf den Qualifikationsstufen Bachelor, Master, PhD und Data Steward aus einer Reihe von nationalen wie internationalen Projekten und Fortbildungskonzepten zum Themenbereich FDM in einheitlicher Form zusammen und bietet Nachnutzenden eine Orientierungshilfe für die Identifikation von relevanten Inhaltsaspekten sowie eine Arbeitsgrundlage, etwa für eine erweiterte fach- oder veranstaltungsspezifische Ausgestaltung. Die Lernzielmatrix entstand im Rahmen der DINI/nestor AG Forschungsdaten UAG Schulungen/Fortbildungen unter Einbezug externer Kolleg*innen.
Additional file 2 of Real-world evidence of treatment patterns and survival of metastatic gastric cancer patients in Germany
Creators: name: Luna, Jaime
name: Picker, Nils
name: Wilke, Thomas
name: Lutz, Magnus
name: Hess, Jürgen
name: Mörtl, Bernhard
name: Xiong, Yan
name: Götze, Thorsten Oliver
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2.