cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficacy of heel lifts for lower limb musculoskeletal conditions: A systematic review
Creators: name: Bourke, Jaryd
name: Munteanu, Shannon
name: Merza, E
name: Garofolini, A
name: Taylor, S
name: Malliaras, P
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4207
subject: Sports science and exercise
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 4201
subject: Allied health and rehabilitation science

description: Introduction: The objective of this systematic review is to determine the benefits and harms of heel lifts to any comparator for lower limb musculoskeletal conditions. Methods: Ovid MEDLINE, Ovid AMED, Ovid EMCARE, CINAHL Plus and SPORTDiscus were searched from inception to the end of May 2024. Randomised, quasi-randomised or non-randomised trials comparing heel lifts to any other intervention or no-treatment were eligible for inclusion. Data was extracted for the outcomes of pain, disability/function, participation, participant rating of overall condition, quality of life, composite measures and adverse events. Two authors independently assessed risk of bias and certainty of evidence using the GRADE approach at the primary time point 12 weeks (or next closest). Results: Eight trials (n = 903), investigating mid-portion Achilles tendinopathy, calcaneal apophysitis and plantar heel pain were included. Heel lifts were compared to exercise, ultrasound, cryotherapy orthotics, stretching, footwear, activity modification, felt pads and analgesic medication. No outcome was at low risk of bias and few effects (2 out of 47) were clinically important. Low-certainty evidence (1 trial, n = 199) indicates improved pain relief (55.7 points [95% CI: 50.3–61.1], on a 100 mm visual analogue scale) with custom orthotics compared to heel lifts at 12 weeks for calcaneal apophysitis. Very low-certainty evidence (1 trial, n = 62) indicates improved pain and function with heel lifts over indomethacin (35.5 points [95% CI: 21.1–49.9], Foot Function Index) at 12 months for plantar heel pain. Conclusions: Few trials have assessed the benefits and harms of heel lifts for lower limb musculoskeletal conditions. Only two outcomes out of 47 showed clinically meaningful between group differences. However, due to very low to low certainty evidence we are unable to be confident in the results and the true effect may be substantially different. Registration: PROSPERO registration number CRD42022309644.
Linkage Isomerization in Nitrosothiols (RSNOs): The X-ray Crystal Structure of an S-nitrosocysteine and DFT Analysis of Its Metastable MS1 and MS2 Isomers
Creators: name: Powell, Douglas R.
name: Yi, Jun
name: Coppens, Philip
name: Richter-Addo, George B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Density functional theory calculations reveal that the previously unreported nitrosothiol MS1 and MS2 linkage isomers are metastable species with energies similar to those determined for other experimentally observed XNO linkage isomers.Nitrosation of protein cysteines to yield S-nitrosocysteine (cySNO) is an important component of nitric oxide biology. However, high-resolution structural data of cySNO in the absence of protein environment effects is lacking, as is information on cySNO linkage isomers. We report the ordered X-ray crystal structure of a cySNO compound. We employ density functional theory calculations to probe the ground-state and linkage isomers of cySNO, CH3SNO, and CF3SNO. The HOMO of CH3SNO contains an intramolecular CH···O interaction that helps rationalize the stability of the cis conformation; this interaction is absent in CF3SNO, which favors the trans conformation. We show that the isonitroso MS1 (RSON) and side-on MS2 (RS(η2-ON)) linkage isomers are metastable species, with MS1 and MS2 energies similar to those of other experimentally observed nitroso linkage isomers.
Additional file 6 of Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
Creators: name: Gallagher, Hugh
name: Dumbleton, Jennifer
name: Maishman, Tom
name: Whitehead, Amy
name: Moore, Michael V.
name: Fuat, Ahmet
name: Fitzmaurice, David
name: Henderson, Robert A.
name: Lord, Joanne
name: Griffith, Kathryn E.
name: Stevens, Paul
name: Taal, Maarten W.
name: Stevenson, Diane
name: Fraser, Simon D.
name: Lown, Mark
name: Hawkey, Christopher J.
name: Roderick, Paul J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer

description: Additional file 6. Protocol versioning.
Additional file 5 of Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
Creators: name: Gallagher, Hugh
name: Dumbleton, Jennifer
name: Maishman, Tom
name: Whitehead, Amy
name: Moore, Michael V.
name: Fuat, Ahmet
name: Fitzmaurice, David
name: Henderson, Robert A.
name: Lord, Joanne
name: Griffith, Kathryn E.
name: Stevens, Paul
name: Taal, Maarten W.
name: Stevenson, Diane
name: Fraser, Simon D.
name: Lown, Mark
name: Hawkey, Christopher J.
name: Roderick, Paul J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer

description: Additional file 5. SPIRIT checklist.
Quality assessment of prostate cancer reports to the Danish Cancer Registry
Creators: name: Ingimarsdóttir, Inga Jóna
name: Rusch, Ea
name: Engholm, Gerda
name: Storm, Hans H.
name: Brasso, Klaus
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Background. The Danish Cancer Registry (DCR) is the oldest nationwide population-based cancer registry in the Nordic countries. At the time of the study the DCR recorded date of diagnosis, tumor stage and initial treatment. The validity of the clinical information reported to the DCR has never been analyzed. Material and methods. Patients diagnosed with prostate cancer from 1 May to 31 December 1997 and living in eight Danish counties were identified through the DCR. Clinical data was retrieved from hospital records where date of diagnosis, stage at diagnosis and treatment received were registered. Results. The mean age at diagnosis was 74.6 years (s.d. 8.6 years). Diagnosis was verified histologically for 87% of cases. Overall 95% of the patients had a difference less than three months between the reported date of diagnosis and the date found in hospital records. Correction of dates of diagnosis had no impact on survival. Hospital records identified 86 patients with T1-2 disease without distant metastases (M0), but only 56 of these patients (65%) were reported to the DCR as having localized disease. According to hospital records a total of 242 patients were confirmed having distant metastases (M1) at diagnosis but only 139 of these cases (57%) were reported to the DCR as such. Considerable “over reporting” of curative treatment was observed. Conclusion. The DCR has been shown to be reliable in terms of new cases being reported. For the majority of cases there were insignificant differences concerning the date of diagnosis. However, the DCR information on stage and treatment was found to be inaccurate. Since 2004 the DCR registration process, including staging according to the TNM classification, has been carried out electronically from several registers. Future comparison between cohorts of different time intervals or international comparison should be interpreted with caution when clinical information is included.
Efficacy of heel lifts for lower limb musculoskeletal conditions: A systematic review
Creators: name: Bourke, J
name: Munteanu, Shannon
name: Merza, E
name: Garofolini, A
name: Taylor, S
name: Malliaras, P
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4207
subject: Sports science and exercise
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 4201
subject: Allied health and rehabilitation science

description: Introduction: The objective of this systematic review is to determine the benefits and harms of heel lifts to any comparator for lower limb musculoskeletal conditions. Methods: Ovid MEDLINE, Ovid AMED, Ovid EMCARE, CINAHL Plus and SPORTDiscus were searched from inception to the end of May 2024. Randomised, quasi-randomised or non-randomised trials comparing heel lifts to any other intervention or no-treatment were eligible for inclusion. Data was extracted for the outcomes of pain, disability/function, participation, participant rating of overall condition, quality of life, composite measures and adverse events. Two authors independently assessed risk of bias and certainty of evidence using the GRADE approach at the primary time point 12 weeks (or next closest). Results: Eight trials (n = 903), investigating mid-portion Achilles tendinopathy, calcaneal apophysitis and plantar heel pain were included. Heel lifts were compared to exercise, ultrasound, cryotherapy orthotics, stretching, footwear, activity modification, felt pads and analgesic medication. No outcome was at low risk of bias and few effects (2 out of 47) were clinically important. Low-certainty evidence (1 trial, n = 199) indicates improved pain relief (55.7 points [95% CI: 50.3–61.1], on a 100 mm visual analogue scale) with custom orthotics compared to heel lifts at 12 weeks for calcaneal apophysitis. Very low-certainty evidence (1 trial, n = 62) indicates improved pain and function with heel lifts over indomethacin (35.5 points [95% CI: 21.1–49.9], Foot Function Index) at 12 months for plantar heel pain. Conclusions: Few trials have assessed the benefits and harms of heel lifts for lower limb musculoskeletal conditions. Only two outcomes out of 47 showed clinically meaningful between group differences. However, due to very low to low certainty evidence we are unable to be confident in the results and the true effect may be substantially different. Registration: PROSPERO registration number CRD42022309644.
The Life and Times of La Trobe's Department of Environmental Management and Ecology: A Reflective Review
Creators: name: Suter, Phillip
name: Hill, John
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 430302
subject: Australian history
classificationCode: 390303
subject: Higher education

description: A history of the La Trobe University Department of Environmental Management and Ecology
The Life and Times of La Trobe's Department of Environmental Management and Ecology: A Reflective Review
Creators: name: Suter, Phil
name: Hill, John
Publisher: name: La Trobe
Year: 2019
Subjects: subject: 210303 Australian History (excl. Aboriginal and Torres Strait Islander History)
subject: FOS: History and archaeology
subject: 130103 Higher Education
subject: FOS: Educational sciences

description: A history of the La Trobe University Department of Environmental Management and Ecology
Late urinary toxicity modeling after stereotactic body radiotherapy (SBRT) in the definitive treatment of localized prostate cancer
Creators: name: Kole, Thomas P.
name: Tong, Michael
name: Binbin Wu
name: Siyuan Lei
name: Olusola Obayomi-Davies
name: Chen, Leonard N.
name: Simeng Suy
name: Dritschilo, Anatoly
name: Yorke, Ellen
name: Collins, Sean P.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Background. Late urinary symptom flare has been shown to occur in a small subset of men treated with ultra- hypofractionated stereotactic body radiotherapy (SBRT) for prostate cancer. The purpose of this study was to use normal tissue complication probability modeling in an effort to derive SBRT specific dosimetric predictor's of late urinary flare. Material and methods. Two hundred and sixteen men were treated for localized prostate cancer using ultra- hypofractionated SBRT. A dose of 35–36.25 Gy in 5 fractions was delivered to the prostate and proximal seminal vesicles. Functional surveys were conducted before and after treatment to assess late toxicity. Phenomenologic NTCP models were fit to bladder DVHs and late urinary flare outcomes using maximum likelihood estimation. Results. Twenty-nine patients experienced late urinary flare within two years of completion of treatment. Fitting of bladder DVH data to a Lyman NTCP model resulted in parameter estimates of m, TD50, and n of 0.19 (0–0.47), 38.7 Gy (31.1–46.4), and 0.13 (-0.14–0.41), respectively. Subsequent fit to a hottest volume probit model revealed a significant association of late urinary flare with dose to the hottest 12.7% of bladder volume. Multivariate analysis resulted in a final model that included patient age and hottest volume probit model predictions. Kaplan-Meier analysis demonstrated a two-year urinary flare free survival of 95.7% in patients 65 years or older with a bladder D12.7% of 33.5 Gy or less, compared to 74.5% in patients meeting none of these criteria. Conclusion. NTCP modeling of late urinary flare after ultra-hypofractionated prostate SBRT demonstrates a relatively small volume effect for dose to the bladder, suggesting that reduction of volume receiving elevated dose will result in decreased incidence of late urinary toxicity. Future studies will be needed to examine the impact of dose to other potential sources of late genitourinary toxicity.
Additional file 1 of Validity of self-report measures of cannabis use compared to biological samples among women of reproductive age: a scoping review
Creators: name: Skelton, Kara R.
name: Donahue, Erin
name: Benjamin-Neelon, Sara E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Large Eddy simulation of supersonic combustion using a probability density function method
Creators: name: Paixao De Almeida, Yuri
Publisher: name: Imperial College London
Year: 2019

description: The scramjet propulsion system is regarded to be a key technology to deliver the next generation of hypersonic planes. It consists of a ramjet engine in which the combustion occurs at supersonic speed. Experiments have been used to investigate the scramjet engine, however, the high costs of gathering data is a limiting factor in its development. In this context, the numerical simulation is an affordable alternative to shed a light into supersonic combustion. The simulation of high-speed compressible and reactive flows, however, is not straightforward, including shock/boundary layer interactions and combustion. Nonetheless, most combustion models have been designed for subsonic flames and their portability to high-speed flows is non-trivial. This work investigates the use of the Probability Density Function (PDF) method for supersonic combustion within the Large Eddy Simulation (LES) framework. Two methods are considered: one is an extension of a joint scalar PDF model (SPDF) for high speed flows and the other is a new joint velocity-scalar PDF formulation (VSPDF). The LES-PDF equations are solved using the Eulerian stochastic fields method, which is implemented into the in-house compressible code CompReal. Their performance are evaluated through a reactive shock-tube, mixing layers and a homogeneous isotropic turbulence cube simulation. Two supersonic burner configurations are simulated to validate the code against experimental data. The results show that sub-grid contributions are important at coarse meshes and the stochastic fields approach can reproduce experimental results. The University of Virginia scramjet configuration A is also simulated using the joint scalar PDF model. Results of topwall pressure, temperature and molar fractions are compared with experimental data. Overall, the results suggest that the joint scalar PDF is the most robust and reliable formulation and the sub-grid closures for the joint velocity-scalar PDF require further investigation.
Introduction - Spiritual Care for Allied Heath Practice
Creators: name: Rumbold, Bruce
Publisher: name: La Trobe
Year: 2018
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Rumbold, B. (2018) Introduction. In: Carey, L.B. & Mathisen, B.A. Spiritual Care for Allied Health Practice: A Person-Centered Approach (Chapter 1: pp: 1-21). London: Jessica Kingsley Publishers [ISBN 9781785922206]. DOI10.4225/22/5ae16cdc3c99f
Summary: The goal of spiritual care in healthcare settings is for the patient, or client, to bring together the disconnected aspects of new experiences and the fragmented understandings that are produced by the disruptive impact of injury or illness. Ultimately, it is up to the person to reassemble those pieces and restore some coherence to the story of their lives. Spiritual care comprises strategies to elicit resources, point to options, remind people of their previous capabilities to transcend, and set up reflective spaces in which people can gather themselves. A range of professional caregivers can support spiritual care in healthcare settings, with each person’s contribution located by their role in the client’s treatment and rehabilitation. Allied health practitioners have an important place in spiritual care, because they work on tasks that generate possibilities from the client’s illness experience.
Introduction - Spiritual Care for Allied Heath Practice
Creators: name: Rumbold, Bruce
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Rumbold, B. (2018) Introduction. In: Carey, L.B. & Mathisen, B.A. Spiritual Care for Allied Health Practice: A Person-Centered Approach (Chapter 1: pp: 1-21). London: Jessica Kingsley Publishers [ISBN 9781785922206]. DOI10.4225/22/5ae16cdc3c99f
Summary: The goal of spiritual care in healthcare settings is for the patient, or client, to bring together the disconnected aspects of new experiences and the fragmented understandings that are produced by the disruptive impact of injury or illness. Ultimately, it is up to the person to reassemble those pieces and restore some coherence to the story of their lives. Spiritual care comprises strategies to elicit resources, point to options, remind people of their previous capabilities to transcend, and set up reflective spaces in which people can gather themselves. A range of professional caregivers can support spiritual care in healthcare settings, with each person’s contribution located by their role in the client’s treatment and rehabilitation. Allied health practitioners have an important place in spiritual care, because they work on tasks that generate possibilities from the client’s illness experience.
Novel characterization method of ceria-based catalyst and electrode in solid oxide fuel cells
Creators: name: Ouyang, Mengzheng
Publisher: name: Imperial College London
Year: 2019

description: Due to the worldwide rising awareness for environmental protection, there is a needfor novel energy sourceswith high efficiency and low pollutant emission. Solid oxide fuel cells (SOFCs) have received more and more attention for their ability to fulfill such requirementsand theirfuel flexibility. Materials with mixed ionic and electronic conductivity (MIEC) have emerged to be a promising class of candidates for SOFCs’ electrodes. However, due to the participation of dual-phase boundary and the resulting complex electrochemical and chemical reaction mechanism, the knowledge on the properties of MIEC materials is still insufficient. Therefore, it is difficult to quantitatively assess the relation of microstructures and performance of MIEC electrodes and efficiently improve the design strategy. In this thesis, efforts are made on the development of characterization method for gadolinium-doped ceria anode for SOFCs, to investigate the mechanism of hydrogen and methane reaction on the electrodes and the relationship between the performance and microstructures. A meliorated methane pulse transient experiments is first performed onimpregnated Ni/CGO catalyst along with in-situ Raman spectroscopy. Through qualitative and quantitative analysis of the peaks, the mechanism of methane oxidation on Ni/CGO is revealed. Furthermore, the relationship of Ni surface area, CGO oxidation state,CGO surface oxygen with the methane uptake and carbon resistance is revealed. This implication is further applied in combined with electrochemical impedance spectroscopy in the characterization of aged Ni/CGO electrodes, to investigate the influence of aging to its performance. The influence of co-impregnation of Cu is also investigated via methane pulse transient experiment. In the final chapter, a general approach of deconvoluting the DPB and TPB processes in MIEC electrodes is developed and applied to summarize a general design strategy for this class of materials. According to the strategy a novel structure is synthesized and shows better performance compared with conventional structures.
Public interest in and acceptability of the prospect of risk-stratified screening for breast and prostate cancer
Creators: name: Koitsalu, Marie
name: Sprangers, Mirjam A. G.
name: Eklund, Martin
name: Czene, Kamila
name: Hall, Per
name: Grönberg, Henrik
name: Brandberg, Yvonne
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Background. For risk-stratified screening to be implemented as a screening program for breast and prostate cancer it has to be accepted among the general population. Investigating public interest in stratified screening and its acceptability to the public is therefore essential since as yet little is known. Method. Cross-sectional web survey sent to a sample of 10 000 individuals (20–74 years of age) representative of the Swedish population as registered in 2009. Results. Among the responders (28%), a vast majority (94%) expressed an interest in knowing their breast or prostate cancer risk and stated wanting to know to ‘avoid worrying’. Men and women were equally interested in knowing their prostate and breast cancer risk, respectively. However, men showed more certainty. Trusting the healthcare workers with personal information (63%) as well as genetic information (70%), in order to calculate the risk, did not seem to be a major issue. Furthermore, 87% would agree to get screened more often if identified with a high risk, whereas, if identified with a low risk, only 27% would agree to get screened less often. Finally, although a consultation with a physician seemed to be the preferred way to communicate the risk, a majority would agree to receive it via a letter or a phone call. Conclusion. Risk-stratified screening has the possibility to be accepted by the general public. Knowledge about interest and acceptability of the prospect of risk-stratified screening for breast and prostate cancer will help when implementing new screening strategies.
Additional file 2 of Validity of self-report measures of cannabis use compared to biological samples among women of reproductive age: a scoping review
Creators: name: Skelton, Kara R.
name: Donahue, Erin
name: Benjamin-Neelon, Sara E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2.
Extraction of potash values from pyrophyllite mine waste
Creators: name: S. K. Jena
name: N. Dhawan
name: D. S. Rao
name: P. K. Misra
name: B. Das
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Hematology

description: A waste sample generated during the mining of pyrophyllite ore is characterized for the extraction of potash values. Mineral liberation analysis (MLA) reveals that the waste material consists of muscovite, K-Feldspar (orthoclase), and pyrophyllite as the major mineral phases. The sample contains 49.5% SiO2, 23.9% Al2O3, 1.8% Fe2O3, and 9.8% K2O as its prime constituents. An effort has been made for the extraction of potash value by physical and chemical beneficiation techniques. Beneficiation studies using magnetic separation, froth flotation, and even chemical leaching with inorganic acids could not extract any appreciable potash values. Finally, a roast leach method using calcium chloride followed by leaching in water has been employed. The process variables such as calcium chloride dosage, roasting time, and temperature are optimized using L9 Taguchi statistical design. It has been possible to achieve about 85% potash values at 900°C, 45 minutes of roasting time and calcium chloride dosage of 75% with respect to the ore. The change in mineral phases in the feed, roast, and leached residue has been characterized by X-ray diffraction (XRD) and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), which shows the phase conversion into wollastonite and halite potassian.
Investigating competitive interactions between normal and transformed neural stem cells
Creators: name: Lawlor, Katerina Marie
Publisher: name: Imperial College London
Year: 2019

description: Glioblastoma is the most aggressive subtype of malignant glioma and, despite intensive research efforts, has an extremely poor prognosis with a median survival of just 15 months. It has long been speculated that adult neural stem cells (NSCs) that reside in the subventricular zone (SVZ) of the brain could be the cell of origin in glioblastoma. Indeed, it has been demonstrated that murine SVZ NSCs, which have lost the Ink4a/Arf tumour suppressor locus and express a constitutively active form of the epidermal growth factor receptor, EGFRvIII, are able to form aggressive tumours in vivo that recapitulate many of the features of glioblastoma. In this project, I sought to investigate the interactions between these transformed NSCs and their wild-type counterparts to determine whether a selective advantage could be aiding their expansion in the niche. I found that, when these cells were co-cultured, transformed NSCs induced wild-type NSCs to dramatically reduce their proliferation rate and adopt a quiescent-like state. This could be observed through a reduction in cell number and a decreased proportion of BrdU-positive wild-type cells in co-culture compared to homogenous culture. Transcriptional profiling also revealed downregulated expression of genes associated with cell cycle progression in co-cultured wild-type NSCs. Importantly, this phenotype was contact dependent, as no reduction in proliferation was observed when the two cell types were physically separated. To test the molecular mechanism underlying this cell cycle repression, I inhibited Notch signalling, a cell-to-cell signalling pathway known to have a role in sustaining NSC proliferation. Interestingly, I found that both treatment with γ-secretase inhibitors and genetic deletion of key Notch signalling genes rescued the proliferation of wild-type NSCs in co-culture. Together these results indicate that NSCs that acquire oncogenic mutations expand in the niche in part by suppressing the growth of surrounding NSCs in a Notch-dependent manner.
Prosthetics, Orthotics and Spiritual Care
Creators: name: Fisher, Kerry
name: Francis, Anthony
name: Collins, Nathan
Publisher: name: La Trobe
Year: 2018
Subjects: Health Care

description: Kerry Fisher, Anthony Francis, & Nathan Collins (2018).Prosthetics, Orthotics and Spiritual Care. In: Carey, L.B. & Mathisen, B.A. Spiritual Care for Allied Health Practice: A Person-Centered Approach (Chapter 10: pp: 207-228). London: Jessica Kingsley Publishers [ISBN 9781785922206]. https://doi.org/10.4225/22/5ae18534bbac0
Summary: This chapter considers the role of the prosthetics and orthotics profession with regard to spiritual care in the context of a client-centered model. It is not proposed that every prosthetist/orthotists should necessarily be competent in or attempt spiritual assessment or counselling. However, it is proposed that they should increase their awareness of spiritual factors influencing the health and wellbeing of their clients, and improve their competence and confidence to engage with their clients about the role that spirituality may have in a client’s life.
SPARQLing Ogham Stones - Blogpost
Creators: name: Schmidt, Sophie Charlotte
name: Thiery, Florian
Publisher: name: Zenodo
Year: 2020
Subjects: subject: best practices
subject: data
subject: interdisciplinarity
subject: ogham
subject: repositories
subject: Wikidata
subject: http://www.wikidata.org/entity/Q71937877
subject: http://www.wikidata.org/entity/Q70873595
subject: http://www.wikidata.org/entity/Q184661

description: This is a blogpost from Archaeoloinformatics.net. http://archaeoinformatics.net/linked-and-sparqling-ogham-stones/
A study on natural clinoptilolite for CO2/N2 gas separation
Creators: name: Karousos, Dionysios S.
name: Sapalidis, Andreas A.
name: Kouvelos, Evangelos P.
name: Romanos, George Em.
name: Nickolaos K. Kanellopoulos
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology

description: Based on its low cost and low water adsorption capacity, compared to synthetic zeolites (A-type, X-type and Y-type), natural, untreated clinoptilolite was examined as a potential adsorbent for a separation process targeting on removal of CO2 from flue gas. Taking into consideration typical flue gas composition and temperature, adsorptive properties of binary CO2/N2 mixtures were tested in the temperature range of 268 to 403 K and compared with literature data. The results showed that CO2 concentration, total pressure, and temperature strongly affect selectivity and working capacity, restricting the conditions under which the material could be used as an efficient adsorbent.
Additional file 1 of The KIDSCREEN-27 scale: translation and validation study of the Slovenian version
Creators: name: Budler, Leona Cilar
name: Pajnkihar, Majda
name: Ravens-Sieberer, Ulrike
name: Barr, Owen
name: Stiglic, Gregor
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Supplement 1: Mokken Scaling for KIDSCREEN subscales items.
Extraction of potash values from pyrophyllite mine waste
Creators: name: S. K. Jena
name: N. Dhawan
name: D. S. Rao
name: P. K. Misra
name: B. Das
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Hematology

description: A waste sample generated during the mining of pyrophyllite ore is characterized for the extraction of potash values. Mineral liberation analysis (MLA) reveals that the waste material consists of muscovite, K-Feldspar (orthoclase), and pyrophyllite as the major mineral phases. The sample contains 49.5% SiO2, 23.9% Al2O3, 1.8% Fe2O3, and 9.8% K2O as its prime constituents. An effort has been made for the extraction of potash value by physical and chemical beneficiation techniques. Beneficiation studies using magnetic separation, froth flotation, and even chemical leaching with inorganic acids could not extract any appreciable potash values. Finally, a roast leach method using calcium chloride followed by leaching in water has been employed. The process variables such as calcium chloride dosage, roasting time, and temperature are optimized using L9 Taguchi statistical design. It has been possible to achieve about 85% potash values at 900°C, 45 minutes of roasting time and calcium chloride dosage of 75% with respect to the ore. The change in mineral phases in the feed, roast, and leached residue has been characterized by X-ray diffraction (XRD) and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), which shows the phase conversion into wollastonite and halite potassian.
NEUES SEHEN – Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft
Creators: name: Günther, Elisabeth
name: Sascha, Schmitz
name: Bleser, Eva
name: Drechsler, Michael
name: Feld, Nico
name: Mahler, Karl-Uwe
Publisher: name: Digital Classics Online
Year: 2024

description: Die Konferenz NEUES SEHEN. Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft, die vom 20. bis 22.05.2022 an der Universität Trier stattfand, untersuchte das Potenzial digitaler Werkzeuge und Methoden, die auf archäologische Objekte und Bilder angewendet werden können. Dieser vierte Teil des Tagungsbandes erörtert das Potenzial der digitalen Archäologie für den interinstitutionellen Austausch zwischen Universität, Museum und Landesamt für Denkmalpflege, mit besonderem Fokus auf die Stadt Trier (Session 4 der Tagung).
description: Digital Classics Online, Bd. 9 (2023)
Prosthetics, Orthotics and Spiritual Care
Creators: name: Fisher, Kerry
name: Francis, Anthony
name: Collins, Nathan
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 420306
subject: Health care administration

description: Kerry Fisher, Anthony Francis, & Nathan Collins (2018).Prosthetics, Orthotics and Spiritual Care. In: Carey, L.B. & Mathisen, B.A. Spiritual Care for Allied Health Practice: A Person-Centered Approach (Chapter 10: pp: 207-228). London: Jessica Kingsley Publishers [ISBN 9781785922206]. https://doi.org/10.4225/22/5ae18534bbac0
Summary: This chapter considers the role of the prosthetics and orthotics profession with regard to spiritual care in the context of a client-centered model. It is not proposed that every prosthetist/orthotists should necessarily be competent in or attempt spiritual assessment or counselling. However, it is proposed that they should increase their awareness of spiritual factors influencing the health and wellbeing of their clients, and improve their competence and confidence to engage with their clients about the role that spirituality may have in a client’s life.
Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial
Creators: name: Lin, Chun-Yuan
name: Sun-Yuan Liang
name: Yue-Cune Chang
name: Shuo-Yen Ting
name: Ching-Ling Kao
name: Yu-Hsin Wu
name: Guochuan E. Tsai
name: Hsien-Yuan Lane
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives Hypofunction of NMDA receptor is implicated in the pathophysiology, particularly cognitive impairment, of schizophrenia. Sarcosine, a glycine transporter I (GlyT-1) inhibitor, and sodium benzoate, a d-amino acid oxidase (DAAO) inhibitor, can both enhance NMDA receptor-mediated neurotransmission. We proposed simultaneously inhibiting DAAO and GlyT-1 may be more effective than inhibition of either in improving the cognitive and global functioning of schizophrenia patients. Methods This study compared add-on sarcosine (2 g/day) plus benzoate (1 g/day) vs. sarcosine (2 g/day) for the clinical symptoms, as well as the cognitive and global functioning, of chronic schizophrenia patients in a 12-week, double-blind, randomised, placebo-controlled trial. Participants were measured with the Positive and Negative Syndrome Scale and the Global Assessment of Functioning Scale every 3 weeks. Seven cognitive domains, recommended by the Measurement and Treatment Research to Improve Cognition in Schizophrenia Committee, were measured at weeks 0 and 12. Results Adjunctive sarcosine plus benzoate, but not sarcosine alone, improved the cognitive and global functioning of patients with schizophrenia, even when their clinical symptoms had not improved. Conclusions This finding suggests N-methyl-d-aspartate receptor-enhancement therapy can improve the cognitive function of patients with schizophrenia, further indicating this pro-cognitive effect can be primary without improvement in clinical symptoms.
NEUES SEHEN – Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft
Creators: name: Günther, Elisabeth
name: Bendschus, Torsten
name: Deligio, Chrisowalandis
name: Hofmann, Kerstin P.
name: Kipke, Marta
name: Langner, Martin
name: Reinhardt, Corinna
name: Rösler, Katja
name: Verstegen, Ute
Publisher: name: Digital Classics Online
Year: 2023

description: Die Konferenz NEUES SEHEN. Aktuelle Ansätze der Digitalen Archäologie in der Objekt und Bildwissenschaft, die vom 20. bis 22.05.2022 an der Universität Trier stattfand, untersuchte das Potenzial digitaler Werkzeuge und Methoden, die auf archäologische Objekte und Bilder angewendet werden können. Entsprechend den vier Sessions der Konferenz werden wir in Digital Classics Online (DCO) eine Reihe von vier Beiträgen veröffentlichen, die jeweils eine kurze Einführung der Organisatoren, die Abstracts der während der Session vorgestellten Projekte und eine Mitschrift einer Gruppendiskussion zwischen den jeweiligen Referenten enthalten. Dieser dritte Teil konzentriert sich auf das Potenzial der Mustererkennung und die Anwendung von KI in der archäologischen Forschung.
description: Digital Classics Online, Bd. 9 (2023)
NEUES SEHEN – Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft
Creators: name: Günther, Elisabeth
name: Schmitz, Sascha
name: Cordie, Rosemarie
name: Kelp, Ute
name: Klöckner, Anja
name: Langendorf, Alarich
name: Meinecke, Katharina
name: Süß, Jürgen
Publisher: name: Digital Classics Online
Year: 2023

description: Die Konferenz NEUES SEHEN. Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft, die vom 20. bis 22.05.2022 an der Universität Trier stattfand, untersuchte das Potenzial digitaler Werkzeuge und Methoden, die auf archäologische Objekte und Bilder angewendet werden. Dieser zweite Teil widmet sich dem Potenzial und den Herausforderungen der 3D-Modellierung (Session 2) als Werkzeug für die archäologische Rekonstruktion in Forschung und Lehre sowie deren Visualisierung und Präsentation für die Öffentlichkeit, z.B. in Museen oder Kulturerbestätten.
description: Digital Classics Online, Bd. 9 (2023)
A study on natural clinoptilolite for CO2/N2 gas separation
Creators: name: Karousos, Dionysios S.
name: Sapalidis, Andreas A.
name: Kouvelos, Evangelos P.
name: Romanos, George Em.
name: Nickolaos K. Kanellopoulos
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology

description: Based on its low cost and low water adsorption capacity, compared to synthetic zeolites (A-type, X-type and Y-type), natural, untreated clinoptilolite was examined as a potential adsorbent for a separation process targeting on removal of CO2 from flue gas. Taking into consideration typical flue gas composition and temperature, adsorptive properties of binary CO2/N2 mixtures were tested in the temperature range of 268 to 403 K and compared with literature data. The results showed that CO2 concentration, total pressure, and temperature strongly affect selectivity and working capacity, restricting the conditions under which the material could be used as an efficient adsorbent.
NEUES SEHEN – Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft
Creators: name: Günther, Elisabeth
name: Brünenberg, Clemens
name: Mischka, Carsten
name: Mischka, Doris
name: Stroth, Fabian
Publisher: name: Digital Classics Online
Year: 2023

description: Die Konferenz NEUES SEHEN. Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft, die vom 20. bis 22.05.2022 an der Universität Trier stattfand, untersuchte das Potenzial digitaler Werkzeuge und Methoden, die auf archäologische Objekte und Bilder angewendet werden können. Dieser erste Teil befasst sich mit der Rolle, die digitale Werkzeuge und Methoden in der akademischen Lehre spielen – und spielen sollten – (Session 3 der Konferenz), mit den technischen und didaktischen Herausforderungen, denen man sich im Seminarraum stellen muss, und mit der Frage, wie Lehre und Forschung in der digitalen Archäologie unsere Disziplin in der (sehr nahen) Zukunft prägen werden.
description: Digital Classics Online, Bd. 9 (2023)
NEUES SEHEN – Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft
Creators: name: Günther, Elisabeth
name: Schmitz, Sascha
Publisher: name: Digital Classics Online
Year: 2023

description: Die Konferenz NEUES SEHEN. Aktuelle Ansätze der Digitalen Archäologie in der Objekt- und Bildwissenschaft, organisiert von Elisabeth Günther und Sascha Schmitz an der Universität Trier (20.–22.05.2022), war den Potenzialen digitaler Anwendungen und Methoden bei der wissenschaftlichen Auseinandersetzung mit archäologischen (Bild-)Objekten gewidmet. Die Einführung stellt Aufbau und Inhalt der Konferenz vor.
description: Digital Classics Online, Bd. 9 (2023)
Cladistic analysis of the Stephaniellaceae (Marchantiophyta) based on morphological data
Creators: name: JuÁrez-MartÍnez, Catalina
name: Ochoterena, Helga
name: Delgadillo-Moya, Claudio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This work evaluates the phylogenetic relationships between Stephaniellaceae, Arnelliaceae, Southbyaceae, and Gymnomitriaceae, and between genera and species of the Stephaniellaceae. We analysed morphological data obtained from herbarium specimens and from the literature under the parsimony criterion using equal weightings and implied weightings. The inclusion of Stephaniella and Stephaniellidium within Arnelliaceae, Southbyaceae or Gymnomitriaceae is not supported in this analysis. The clade Stephaniellaceae had a moderately high Jackknife support and the family was characterized by the following synapomorphies: presence of paraphyllia and presence of longitudinal folds in female bracts. Within the Stephaniellaceae, Stephaniella is corroborated as monophyletic and Stephaniellidium is resolved as its sister group. The relationship between Stephaniella uncifolia Winkler and Stephaniella hamata Stephani was strongly supported in both analyses while the relationship between Stephaniella paraphyllina Jack and Stephaniella boliviensis Stephani was weakly supported. With these results, S. boliviensis is proposed as a synonym of S. paraphyllina. We propose changes in the taxonomic position of Stephaniella and Stephaniellidium and in their classification in consideration of the complex morphology of the species and the lack of sexual structures and collections.
Anion-driven Ag(I) coordination architectures: structural diversity and photoluminescence behaviors
Creators: name: Jiyong Hu
name: Junshuai Zhang
name: Jin’an Zhao
name: Liangliang Hu
name: Shufang Chen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology

description: To observe anion impact on structural diversity of coordination architectures, three 1-D Ag(I) complexes with distinct features have been prepared, {[Ag(bpbib)2(NO3)]·C3NH9O)}n (1), [Ag2(bpbib)2·(BF4)2]n (2), and [Ag2(bpbib)2·(ClO4)2]n (3), by the reactions of 4,4′-bis((2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl)biphenyl (bpbib) with Ag(I) salts. Complex 1 is a 1-D helical chain, whereas 2 and 3 bear ligand-unsupported Ag(I)···Ag(I) interaction-directed 1-D structural motif, with synergetic working of flexible organic linker and anions. All complexes exhibit strong triplet state emission at cryogenic temperatures, which profits from the reduction of nonradiative transitions.