cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of The Gini coefficient as a useful measure of malaria inequality among populations
Creators: name: Abeles, Jonathan
name: Conway, David J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Text S1. Calculating the Gini coefficient and bootstrap 95% confidence intervals using R version 3.6.3. Table S1. Gini coefficients of inequality among WHO world regions in the estimated burden (per 100,000 of the population) of major global diseases. Table S2. No decline in the Gini coefficient of global malaria inequality based on estimated malaria cases as a percentage of Population at Risk between 2010 and 2018. Table S3. No decline in the Gini coefficient of malaria inequality among 16 West African countries based on estimated malaria cases as a percentage of Population at Risk between 2010 and 2018. Table S4. Gini coefficients show differences among West African countries in the levels of sub-national variation in malaria parasite prevalence in community surveys of children <5 years of age. Table S5. Gini coefficients show extent of variation in community prevalence of P. falciparum among 16 villages in the Garki Project in northern Nigeria in eight cross-sectional surveys during the pre-intervention phase of the project. Figure S1. High Gini coefficients of variation in P. falciparum prevalence among villages in The Gambia with seasonal malaria transmission. Variation was analysed among 20 villages each surveyed at two seasonal times.
KMD Sag
Creators: Kerteminde Gl. Kommune
Langeskov Kommune
Munkebo Kommune
Kerteminde Ny Kommune
Publisher: name: Rigsarkivet
Year: 2023

description: Kerteminde Kommune anvender KMD Sag EDH til registrering og styring hovedsagelig af borgersager. I KMD Sag EDH har brugerne adgang til at se/læse eller sagsbehandle sager, journalnotater, adviser (erindringer) inden for deres arbejdsområde.
Derudover modtager brugerne også ’dagens post’. Brugerne har forskellige rolleprofiler og derved har de forskellige adgange til at se/læse, registrere og sagsbehandle ind i systemet.
Majorana modes in smooth normal-superconductor nanowire junctions
Creators: name: Osca, Javier
name: Serra, Llorens
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A numerical method to obtain the spectrum of smooth normal-superconductor junctions in nanowires, able to host Majorana zero modes, is presented. Softness in the potential and superconductor interfaces yields opposite effects on the protection of Majorana modes. While a soft potential is a hindrance for protection, a soft superconductor gap transition greatly favors it. Our method also points out the possibility of extended Majorana states when propagating modes are active far from the junction, although this requires equal incident fluxes in all open channels.
description: 10 pages, 13 figures
Room for Improvement in the New York State Pharmacy-Based Syringe Access Program
Creators: name: Logan, Katherine
name: Deutsch, Sarah
Publisher: name: Columbia University
Year: 2015
Subjects: Medicine
Medical sciences
Health services administration
Medical care
Public health
Drugs

description: Pharmacies in New York State can opt-in to a pharmacy based syringe access program called the Expanded Syringe Access Program (ESAP). Washington Heights CORNER Project, a syringe exchange program in New York City, undertook a two-part survey of pharmacies located less than two miles from the program in Northern Manhattan. The study sought to determine whether pharmacies registered for the Expanded Syringe Access Program were a reliable source of syringes for populations who purchase syringes without a prescription, including people who inject drugs. The surveys found that 71.4% of pharmacies listed on the ESAP directory sold syringes to a Washington Heights CORNER Project participant acting as a secret shopper. A follow up survey assessed pharmacy attitudes toward the program and other harm reduction measures. In this survey, pharmacies demonstrated interest in harm reduction measures, with 92% of pharmacies reporting willingness to refer potential customers to a local syringe exchange program. The researchers make recommendations for improvement to pharmacy-based syringe access programs at the individual, community and policy level, including increasing face to face interactions between syringe exchange programs and pharmacies and requiring regular updates to the online directory of ESAP-registered pharmacies.
Rectified Rotational Dynamics of Mobile Inclusions in Two-Dimensional Active Nematics
Creators: name: Ray, Sattvic
name: Zhang, Jie
name: Dogic, Zvonimir
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We investigate the dynamics of mobile inclusions embedded in 2D active nematics. The interplay between the inclusion shape, the boundary-induced nematic order, and the autonomous flow powers the inclusion motion. Disks and achiral gears exhibit unbiased rotational motion, but with distinct dynamics. In comparison, chiral gear-shaped inclusions exhibit long-term rectified rotation, which is correlated with dynamics and polarization of nearby +1/2 topological defects. The chirality of defect polarities and the active nematic texture around the inclusion correlate with the inclusion's instantaneous rotationr ate. Inclusions provide a promising tool for probing the rheological properties of active nematics and extracting ordered motion from the inherently chaotic motion of active nematics.
Theoretical description and measurement of the pion-photon transition form factor
Creators: name: Mikhailov, S. V.
name: Pimikov, A. V.
name: Stefanis, N. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Detailed predictions for the scaled pion-photon transition form factor are given, derived with the method of light-cone sum rules and using pion distribution amplitudes with two and three Gegenbauer coefficients obtained from QCD sum rules with nonlocal condensates. These predictions agree well with all experimental data that are compatible with QCD scaling (and collinear factorization), but disagree with the high-$Q^2$ data of the BaBar Collaboration that grow with the momentum. A good agreement of our predictions with results obtained from AdS/QCD models and Dyson-Schwinger computations is found.
description: 10 pages, 4 figures, 6 references added, minor style corrections, Presented by the first author at the Light-Cone Conference 2013, May 20-24, 2013, Skiathos, Greece
Reduced graphene oxide thin films as ultrabarriers for organic electronics
Creators: name: Yamaguchi, Hisato
name: Granstrom, Jimmy
name: Nie, Wanyi
name: Sojoudi, Hossein
name: Fujita, Takeshi
name: Voiry, Damien
name: Chen, Mingwei
name: Gupta, Gautam
name: Mohite, Aditya D.
name: Graham, Samuel
name: Chhowalla, Manish
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Encapsulation of electronic devices based on organic materials that are prone to degradation even under normal atmospheric conditions with hermetic barriers is crucial for increasing their lifetime. A challenge is to develop 'ultrabarriers' that are impermeable, flexible, and preferably transparent. Another important requirement is that they must be compatible with organic electronics fabrication schemes (i.e. must be solution processable, deposited at room temperature and be chemically inert). Here, we report lifetime increase of 1,300 hours for poly(3-hexylthiophene) (P3HT) films encapsulated by uniform and continuous thin (~10 nm) films of reduced graphene oxide (rGO). This level of protection against oxygen and water vapor diffusion is substantially better than conventional polymeric barriers such as CytopTM, which degrades after only 350 hours despite being 400 nm thick. Analysis using atomic force microscopy, x-ray photoelectron spectroscopy and high resolution transmission electron microscopy suggest that the superior oxygen gas/moisture barrier property of rGO is due to the close interlayer distance packing and absence of pinholes within the impermeable sheets. These material properties can be correlated to the enhanced lag time of 500 hours. Our results provide new insight for the design of high performance and solution processable transparent 'ultrabarriers' for a wide range of encapsulation applications.
description: Advanced Energy Materials (2013)
title: Sperm Mitochondrial DNA Biomarkers as a Measure of Male Fecundity and Overall Sperm Quality
Creators: name: Rosati, Allyson
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Introduction. Sperm parameter analysis is the standard method of male fecundity testing; however, minimal evidence supports associations between individual sperm parameters and reproductive outcomes. Our previous work shows strong associations between sperm mitochondrial DNA copy number (mtDNAcn) and time-to-pregnancy (TTP) in general populations, and between mtDNAcn and fertilization outcomes in clinical populations. Thus it is possible for sperm mtDNA biomarkers to act as summary measures of semen quality. In this study, we developed a sperm quality index (SQI) from semen parameters and compared its ability to measure fecundity to sperm mtDNAcn.
Methods. We received 384 semen samples from the Longitudinal Investigation of Fertility in the Environment Study. Sperm mtDNAcn and mtDNA deletions (mtDNAdel) were quantified using a triplex probe-based qPCR method. The SQI was developed by ranking and summing select sperm parameters within the study population, including sperm concentration, sperm count, normal morphology, high DNA stainability, and DNA fragmentation to create a cumulative index. Discrete-time proportional hazards models were used to determine fecundability odds ratios (FOR), indicating associations between mtDNAcn, SQI, and TTP. Receiver operating characteristic (ROC) analyses determined the validity of the SQI and mtDNAcn as predictors of pregnancy within 12 months.
Results. The SQI was highly associated with mtDNAcn, both continuously (Spearman Rho: -0.487; p-value: <0.001) and in deciles (ANOVA p-value: <0.001). The SQI (FOR: 1.25; 95% confidence interval (CI): 1.09, 1.43) and mtDNAcn (FOR: 0.754; 95% CI: 0.657, 0.866) performed similarly in discrete-time survival models and indicated a significant decrease and increase in TTP, respectively. MtDNAcn more effectively predicted pregnancy within 12 months (AUC: 0.703; 95% CI: 0.617, 0.789) than the SQI (AUC: 0.642; 95% CI: 0.531, 0.753). With multiple predictors, mtDNAcn outperformed summary models, with addition of the SQI and percent normal morphology minimally increasing model efficacy (AUC: 0.718, 95% CI: 0.617, 0.819).
Conclusion. The association between the SQI and mtDNAcn suggest that mtDNAcn may serve as a summary biomarker for overall sperm quality. Neither individual nor summed sperm parameters are useful indicators of couple fecundity and reproductive outcomes compared to mtDNAcn. These results suggest that mtDNAcn has potential for use as a biomarker of fecundity.
Negative azimuthal force of a nanofiber-guided light on a particle
Creators: name: Kien, Fam Le
name: Rauschenbeutel, Arno
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We calculate the force of a quasicircularly polarized guided light field of a nanofiber on a dielectric spherical particle. We show that the orbital parts of the axial and azimuthal components of the Poynting vector are always positive while the spin parts can be either positive or negative. We find that, for appropriate values of the size parameter of the particle, the azimuthal component of the force is directed oppositely to the circulation direction of the energy flow around the nanofiber. The occurrence of such a negative azimuthal force indicates that the particle undergoes a negative torque.
description: 13 pages, 10 figures
Momentum - digitale interventioner til at støtte fælles beslutningstagning i psykiatrien
Creators: Region Hovedstadens Psykiatri, PsykiatriskCenter Ballerup, Kompetencecenter forRehabilitering og Recovery
Lone Petersen
Publisher: name: Rigsarkivet
Year: 2023

description: Studies undersøger effekften af en smartphoneapplication til at styrke patient aktivering samt støtte fælles beslutningstagning for personer med en diagnose inden for skizofreni området.Patienter er randomiseret til enten kontrolgruppe bestående af standard behandling: specialiserettidlig interventions behandling for unge med debuterende psykose (OPUS) versus standardbehandling + smartphone appen.
Det primære formål er at undersøge effekten af at bruge appen som supplement til standardbehandling på patient aktivering over en 6 måneders periode. Deltagere måles ved baseline, 3 måneder samt 6 måneder efter baseline. Sekundære outcomes er positive og negative symptomer, funktionsniveau, arbejdsalliance, self-efficacy, tilfredshed med behandling, håbsfølelse, følelse af at være forberedt til beslutningstagning, kommunikation med behandler, antal og varighed af hospitalsindlæggelser, brug af antipsykotisk medicin samt antal kontakter til OPUS. Patientens behandler vil desuden besvare spørgsmål om hvordan behandler oplever arbejdsalliancen samt hvordan de oplever patients engagement i behandlingen. Eksplorative outcomes er brugsmønstre på brugen af appen.
Additional file 1 of Urine creatine metabolite panel as a screening test in neurodevelopmental disorders
Creators: name: Bahl, Shalini
name: Cordeiro, Dawn
name: MacNeil, Lauren
name: Schulze, Andreas
name: Mercimek-Andrews, Saadet
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Computational Biology

description: Additional file 1. Demographics, clinical features, urine creatine panel, neuroimaging and molecular genetic test results of patients who have undergone urine creatine panel and diagnosed with other genetic diagnoses are listed in Supplemental Table 1.
All about us: acknowledging mental illness, psychotherapy, stigma, and shame
Creators: name: Sawyer, Annita
Publisher: name: Columbia University
Year: 2015
Subjects: Medicine
Medical sciences
Health services administration
Medical care
Mental health

description: This article explores compromising effects of stigma regarding mental illness and, by association, psychotherapy. Using examples from her years as a young psychiatry patient decades earlier, the author describes her own attitude, which reflected that stigma. This self-prejudice – shame and fear of stigma – compelled her to hide her hospital history and ongoing psychotherapy for most of her life. Many respected mental health professionals confide similar fears and avoid disclosure to protect themselves and their reputations. The author posits that medical professionals’ high status in our society offers each of us an opportunity to modify that stigma, if we dare to acknowledge personal psychological struggles and involvement in psychotherapy. Framing the essay, a recent exchange from the author’s psychotherapy practice illustrates both the potential of disclosure to encourage participation, and the powerful stigma that ultimately overwhelmed her patient’s willingness to pursue treatment, underscoring our responsibility as professionals to act.
title: Protest wider das öffentliche Sittenzeugniß, welches der H. Abgeordnete Kolb von Speyer nach dem Vorgange des H. Abgeordneten Lette aus Berlin dem bayerischen Volksstamme auszustellen für gut fand; [1848]
title: [Frankfurt am Main, den 19. Juli 1848]
titleType: Subtitle
Creators: name: Sepp, Johann Nepomuk
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel
title: Inclusion and Exclusion of Gender, Social Class, Race and Ability  in Elementary German Textbooks
Creators: name: Keenan, Emmalie
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Elementary German language textbooks today lack diverse representations of gender, social class, race, and ability. This thesis argues that the exclusion of those categories of diversity impedes the objectives of the communicative learning approach for students in first-year German courses. It examines research on diversity in textbooks with a focus on the concept of the “third space”, and shows how these findings apply to German students. An analysis of chapters from three German textbooks published between 2018 and 2020: Netzwerk neu A1, Impuls Deutsch 1, and Grenzenlos Deutsch provides specific examples of how images, texts, dialogs, grammar, and vocabulary exercises could be designed or redesigned to make the German language classroom a space in which all students are able to communicate and express themselves.
Should there be specialty courts for medical malpractice litigation?
Creators: name: Chodos, Joel
Publisher: name: Columbia University
Year: 2015
Subjects: subject: Medicine
subject: Medical sciences
subject: Health services administration
subject: Medical care
subject: Law
subject: FOS: Law

description: Medical malpractice suits consume time, money and energy. They strike fears of nightmarishly lengthy, complex litigation in the minds of health care providers. Ill or injured patients filing such suits feel wronged, unsure of what really happened and desperately seek justice and compensation. The current tort system with jury trials, in place in America for over 200 years, is cumbersome, slow, and yields often unpredictable results. Establishing working judicial standards of what constitutes malpractice in specific clinical situations is difficult in the existing system. Specialty health care courts have been proposed as an alternative. In this paper, I look at the scope of the current problem in terms of numbers of suits, costs – both economic and non-economic – and the reality of the current system versus what it is supposed to do. Who currently benefits and which injured parties are left behind are discussed, as are jury limitations. Other examples of specialty courts, such as Delaware’s Court of Chancery for business and the Workman’s Compensation system, will be discussed as precedents for an analogous system for health care. This lays the foundation for a rationale for healthcare specialty courts and a discussion of some proposed systems. Advantages and disadvantages of health care courts are reviewed.
Additional file 2 of Birth attendants’ hand hygiene compliance in healthcare facilities in low and middle-income countries: a systematic review
Creators: name: Gon, Giorgia
name: Barra, Mícheál De
name: Dansero, Lucia
name: Nash, Stephen
name: Campbell, Oona M. R.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. “PRISMA 2009 Checklist” – It includes the details of our manuscript against the PRISMA checklist.
Polyhedral realizations for crystal bases of integrable highest weight modules and combinatorial objects of type ${\rm A}^{(1)}_{n-1}$, ${\rm C}^{(1)}_{n-1}$, ${\rm A}^{(2)}_{2n-2}$, ${\rm D}^{(2)}_{n}$
Creators: name: Kanakubo, Yuki
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Algebra (math.QA)
subject: Combinatorics (math.CO)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In this paper, we consider polyhedral realizations for crystal bases $B(λ)$ of irreducible integrable highest weight modules of a quantized enveloping algebra $U_q(\mathfrak{g})$, where $\mathfrak{g}$ is a classical affine Lie algebra of type ${\rm A}^{(1)}_{n-1}$, ${\rm C}^{(1)}_{n-1}$, ${\rm A}^{(2)}_{2n-2}$ or ${\rm D}^{(2)}_{n}$. We will give explicit forms of polyhedral realizations in terms of extended Young diagrams or Young walls that appear in the representation theory of quantized enveloping algebras of classical affine type. As an application, a combinatorial description of $\varepsilon_k^*$ functions on $B(\infty)$ will be given.
description: 39 pages. arXiv admin note: text overlap with arXiv:2110.14140
Chronic pain, mental health and substance use disorders: how can we manage this triad in our healthcare system and in our communities?
Creators: name: Ross, Sydelle
Publisher: name: Columbia University
Year: 2015
Subjects: Medicine
Medical sciences
Mental health
Health services administration
Medical care

description: The use of opioid analgesics for the treatment of chronic non-cancer pain has become a topic of intense debate in the medical community. Over the last decade there has been a significant rise in the morbidity and mortality associated with the use of these medications. In patients with mental health and substance use disorders, prescribing opioid analgesics for chronic non-cancer pain is perhaps even more challenging. Deficits in training for clinicians, together with a lack of clinical guidelines, make the management of these patients even more difficult. This article serves to provide insight into the clinical management of these patients based on personal experience as well as current established guidelines. It also highlights some of the roles that we can play to help manage this societal problem.
Bending of Sparklers
Creators: name: Abdullah, Mikrajuddin
name: Khairunnisa, Shafira
name: Akbar, Fathan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A new equation is proposed to explain the curvature of spent sparklers. We found the state of a segment of the sparkler to depend strongly on the state of its spent segments. The equation is nearly able to produce the sparkler shape for a range of lengths and for all elevation angles. The method proposed here is likely to explain any phenomena in nature related to an evolving length scale associated with some material that becomes progressively stiff or dry, such as the growth of resin exuded from trees. The equation can produce a very rich spectrum of shapes by varying material parameters (density, temperature-dependent strength), heating temperature, elevation angle, and gravitational acceleration. This might provide new insights into explaining many shapes in nature or man-made structures.
description: 11 pages, 5 figures.Suplementary materials can be obtained from: http://www.mediafire.com/watch/up9hxydyut4x4mn/Sparklers%20of%20zero%20elevation.flv;http://www.mediafire.com/watch/0v1ruq2czrluuwu/Sparklers%20elevated%20at%2060%20degree.flv; Accepted for publication in Eur. J. Phys
The LeRoy catastrophe: A story of death, determination, and the importance of nutrition in medicine
Creators: name: Meguid, Michael
Publisher: name: Columbia University
Year: 2015
Subjects: Medicine
Medical sciences
Health services administration
Medical care
Nutrition

description: In August 1976, a young man named LeRoy fell from a ledge, fracturing his femur. Major internal bleeding was suspected. During a laparotomy, the trauma team ensured that all internal organs were intact and the orthopedic team set his fracture. Thirty days later, LeRoy died. He had eaten little; each day he only received three liters of glucose, the equivalent of 510 calories, intravenously. The glucose was insufficient to meet his nutritional needs, and he lost over 20% of his body weight during his hospital stay. The cause of death was due to “physician- induced” malnutrition. Meanwhile, a paper around the same time documented that the prevalence of malnutrition in Boston hospitals was 44% and that malnutrition itself was a predictor of higher complication and death rates. As a result, like-minded physicians formed a society that created training programs and encouraged formation of hospital nutrition teams. Industry produced nutrition formulas and catheters. Complications in sick hospitalized patients plummeted while survival rates rose, and California passed legislation to mandate nutritional support. Though the health care industry recognized the importance of nutrition in patient care, Congress failed to pass fiscal support for nutrition teams. As a result, hospitals disbanded their newly created nutrition teams, nutrition education and skills declined, and hospital complications and death rates have risen again.
Additional file 1 of Birth attendants’ hand hygiene compliance in healthcare facilities in low and middle-income countries: a systematic review
Creators: name: Gon, Giorgia
name: Barra, Mícheál De
name: Dansero, Lucia
name: Nash, Stephen
name: Campbell, Oona M. R.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. “Systematic review search strategy” – it includes the search strategy for each database used in our review.
Omsorgssystem
Creators: Svendborg Kommune
Publisher: name: Rigsarkivet
Year: 2023

description: Formålet med it-systemet er at samle dokumentation vedr. sagsbehandling, ydelser, intern kommunikation m.v. i forhold til borgere, der modtager ydelser inden for serviceloven, sundhedsloven og lovgivningen for ældre- og plejeboliger. Derudover kunne kommunikere elektronisk med sygehuse, læger, apoteker, andre kommuner i forhold til de gældende sundhedsaftaler. Kunne levere elektronisk data til Danmarks Statistik om borgernes ydelser m.m. samt danne grundlag for styring af økonomi og ressourcer. Kunne opfylde den nationale it-strategi om digitalisering.
Regulation of Fas Expression by STAT3 and c-Jun Is Mediated by Phosphatidylinositol 3-Kinase-AKT Signaling
Creators: name: Ivanov, Vladimir N.
name: Krasilnikov, Mikhail
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2002
Subjects: Protein kinases
Apoptosis
Cytology
Oncology

description: Cooperation between STAT3 and c-Jun results in suppression of Fas Receptor (FasR) transcription, which is often seen in advanced human tumors. To identify requirements for STAT3-Jun cooperation, we elucidated the role of protein kinases that affect both transcription factors. The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway was found capable of down-regulating both STAT3- and c-Jun-dependent transcription, resulting in derepression of FasR transcription. Conversely, inhibition of PI3K-AKT signaling via the specific pharmacological inhibitor LY294002 up-regulated AP1/Jun- and STAT-dependent transcriptional activities, resulting in suppression of the FasR promoter activities and decreased FasR surface expression. PI3K-AKT's ability to affect FasR transcription was not observed in c-jun null fibroblasts, suggesting that c-Jun is required for PI3K/AKT-mediated regulation of FasR transcription. Interestingly, the dominant negative form of Rac1 (RacN17) was also efficient in relieving FasR expression, suggesting that the increase in FasR expression following AKT stimuli could be mediated via AKT ability to elicit suppression of Rac1, which in turn decreases JNK activities and c-Jun phosphorylation. Overall, our findings demonstrate that through its negative effects on both c-Jun and STAT3, the PI3K-AKT pathway disrupts cooperation between c-Jun and STAT3, which is required for silencing the FasR promoter, resulting in increased expression of surface FasR and concomitant sensitization to FasL-mediated programmed cell death.
Additional file 1 of How contact patterns during the COVID-19 pandemic are related to pre-pandemic contact patterns and mobility trends
Creators: name: Lajot, Adrien
name: Wambua, James
name: Coletti, Pietro
name: Franco, Nicolas
name: Brondeel, Ruben
name: Faes, Christel
name: Hens, Niel
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Investigating The Hubble Tension Through Hubble Parameter Data
Creators: name: Thakur, Rahul Kumar
name: Gupta, Shashikant
name: Nigam, Rahul
name: Thiruvikraman, PK
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Hubble constant ($H_0$), which represents the expansion rate of the Universe, is one of the most important cosmological parameters. The recent measurements of $H_0$ using the distance ladder methods such as Type Ia Supernovae (SNe Ia) are significantly greater than the CMB measurements by Planck. The difference points to a crisis in the standard model of cosmology termed as Hubble tension. In this work we compare different cosmological models, determine the Hubble constant and comment on the Hubble tension using the data from differential ages of galaxies. The data we use is free from the systematic effects as the absolute age estimation of the galaxies is not needed. We have used the Bayesian approach along with the commonly used maximum likelihood method to estimate $H_0$ and have calculated the AIC scores to compare the different cosmological models.The non-flat cosmological model provides a higher value for matter density as well as the Hubble constant compared to the flat $Λ$CDM model. The AIC score is smaller for the flat $Λ$CDM cosmology compared to the non-flat model indicating the flat model a better choice. The best-fit value of $H_0$ for both these models are $68.7\pm3.1$ km/s/Mpc and $72.2\pm4$ km/s/Mpc, respectively. Our results are consistent with the CCHP measurements. However, flat model result does not agree with the SH0ES result, while the non-flat result is inconsistent with the Planck value.
description: 9 pages, 2 figures
The Asymptotics of Large Constrained Graphs
Creators: name: Radin, Charles
name: Ren, Kui
name: Sadun, Lorenzo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Social and Information Networks (cs.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We show, through local estimates and simulation, that if one constrains simple graphs by their densities $\varepsilon$ of edges and $τ$ of triangles, then asymptotically (in the number of vertices) for over $95\%$ of the possible range of those densities there is a well-defined typical graph, and it has a very simple structure: the vertices are decomposed into two subsets $V_1$ and $V_2$ of fixed relative size $c$ and $1-c$, and there are well-defined probabilities of edges, $g_{jk}$, between $v_j\in V_j$, and $v_k\in V_k$. Furthermore the four parameters $c, g_{11}, g_{22}$ and $g_{12}$ are smooth functions of $(\varepsilon,τ)$ except at two smooth `phase transition' curves.
Digitaliser.dk
Creators: IT- og Telestyrelsen
Digitaliseringsstyrelsen
Publisher: name: Rigsarkivet
Year: 2023

description: Digitalisér.dk er en social netværksplatform for erfaringsudveksling og videndeling om offentlig digitalisering af Danmark, hvor du blandt andet finder vejledninger, software eller driftsinformationer. Du kan selv oprette en gruppe på Digitalisér.dk, hvis du ønsker at dele viden eller debattere med andre om offentlig digitalisering. Fx om et projekt, driftssamarbejde eller noget helt andet. Digitalisér.dk kan både bruges som projektrum, ideforum og supportrum. Du vælger selv om din gruppe skal have en åben medlemspolitik, som tillader alle at melde sig ind, eller om man skal ansøge eller inviteres til at blive medlem af gruppen (lukket gruppe). På samme vis kan du vælge om alle kan oprette en debat, nyhed eller begivenhed i din gruppen, eller det kun skal være medlemmer af gruppen eller kun administratorer der kan oprette indhold.
Additional file 2 of Fowl adenovirus (FAdV) fiber-based vaccine against inclusion body hepatitis (IBH) provides type-specific protection guided by humoral immunity and regulation of B and T cell response
Creators: name: Luca, Carlotta De
name: Schachner, Anna
name: Taniya Mitra
name: Heidl, Sarah
name: Liebhart, Dieter
name: Hess, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2. Antibody panels. List of antibodies and antibody combinations used in this study.
Vanishing of interband light absorption in a persistent spin helix state
Creators: name: Li, Zhou
name: Marsiglio, F.
name: Carbotte, J. P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Spin-orbit coupling plays an important role in various properties of very different materials. Moreover efforts are underway to control the degree and quality of spin-orbit coupling in materials with a concomitant control of transport properties. We calculate the frequency dependent optical conductivity in systems with both Rashba and Dresselhaus spin-orbit coupling. We find that when the linear Dresselhaus spin-orbit coupling is tuned to be equal to the Rashba spin-orbit coupling, the interband optical conductivity disappears. This is taken to be the signature of the recovery of SU(2) symmetry. The presence of the cubic Dresselhaus spin-orbit coupling modifies the dispersion relation of the charge carriers and the velocity operator. Thus the conductivity is modified, but the interband contribution remains suppressed at most but not all photon energies for a cubic coupling of reasonable magnitude. Hence, such a measurement can serve as a diagnostic probe of engineered spin-orbit coupling.
KMD Børn og Voksne
Creators: Assens Kommune
Fredericia Kommune
Faaborg-Midtfyn Kommune
Hillerød Kommune
Ikast-Brande Kommune
Jammerbugt Kommune
Kalundborg Kommune
Morsø Kommune
Norddjurs Kommune
Nyborg Kommune
Samsø Kommune
Skanderborg Kommune
Solrød Kommune
Svendborg Kommune
Varde Kommune
Vesthimmerlands Kommune
Viborg Kommune
Skive Kommune
Publisher: name: Rigsarkivet
Year: 2023

description: KMD Børn og Voksne anvendes til afregninger for foranstaltninger både over for børn og unge samt voksne og er dermed med til at understøtte kommuners håndtering af især det specialiserede socialområde
Additional file 1 of Increased prevalence of pfdhfr and pfdhps mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Jazan Region, Southwestern Saudi Arabia: important implications for malaria treatment policy
Creators: name: Aymen M. Madkhali
name: Al-Mekhlafi, Hesham M.
name: Atroosh, Wahib M.
name: Ghzwani, Ahmad Hassn
name: Zain, Khalid Ammash
name: Abdulhaq, Ahmed A.
name: Ghailan, Khalid Y.
name: Alkhansa A. Anwar
name: Eisa, Zaki M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Frequency of pfdhfr and pfdhps single mutant alleles for P. falciparum isolates from Jazan, Saudi Arabia according to demographic factors and parasitaemia. Table S2. Frequency distribution of pfdhfr, pfdhps, and combined pfdhfr–pfdhps mutant haplotypes for P. falciparum isolates from Jazan, Saudi Arabia according to governorates.
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis
Creators: name: Krasilnikov, Mikhail
name: Ivanov, Vladimir N.
name: Dong, Jinali
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2003
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Signal transducers and activators of transcription (STAT) proteins nuclear translocation and transcriptional activity are regulated by diverse protein kinases in response to extracellular stimuli by cytokines, growth factors and stress. Using two melanoma-derived cell lines that exhibit marked differences in basal activities of MAPKs and PI3K-AKT, we studied changes both in STAT activities and in their sensitization to apoptosis. Activating mutations of B-RAF (T1796A) and impaired expression of PTEN are detected in LU1205, but not in FEMX melanoma cells, and are reflected in high basal levels of expression and activities of MAPKs and PI3K-AKT. Treatment with either PD98059 (PD) or LY294002 (LY), the pharmacological inhibitors of MEK-ERK and PI3K, respectively, markedly increased GAS-Luc activity in LU1205, but not in FEMX cells. Tyrosine phosphorylation of STAT3/5 and of JAK2 also increased upon treatment of LU1205 cells with either PD or LY, suggesting that constitutive active MAPK and PI3K signals inhibit tyrosine phosphorylation of JAK/STATs. Treatment of FEMX and LU1205 with PD sensitized the cells to apoptosis, albeit by TNFalpha and TRAIL death cascades, respectively, indicating that additional yet distinct targets are affected by each signaling pathway. Indeed, the combination of LY and PD treatment synergistically increased the apoptosis of LU1205 and FEMX cells. Overall, whereas PI3K and MAPK downregulate JAK-STAT signaling, additional targets are affected by these kinases and sensitizes melanoma to apoptosis via distinct death cascades.
Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFα and suppression of NF-κB activities
Creators: name: Ivanov, Vladimir N.
name: Fodstad, Ø
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2001
Subjects: Apoptosis
Melanoma
Radiotherapy
Cytology
Oncology

description: Mechanisms underlying radiation and chemotherapy resistance, the hallmark of human melanoma, are not well understood. Here we demonstrate that expression levels of signal adaptor protein TRAF2 coincide with melanoma resistance to UV-irradiation. Altered TRAF2 signaling by a form of TRAF2, which lacks the ring finger domain (TRAF2ΔN), increases activities of p38 MAPK, ATF2, and the level of TNFα expression. Forced expression of TRAF2ΔN in HHMSX highly metastatic melanoma cells that lack Fas expression and thus utilize the TNFα-TNFR1 as the major apoptotic pathway sensitized cells to UV-induced apoptosis. An over twofold increase in degree of apoptosis was observed in TRAF2ΔN expressing cells that were treated with actinomycin D, anisomycin or with the radiomimetic drug neocarzinostatin. Sensitization by TRAF2ΔN is selective since it was not observed in response to either Taxol or cis-platinum treatment. TRAF2ΔN effects are primarily mediated via p38 since inhibition of p38 reduces, whereas activation of p38 promotes the level of UV-induced apoptosis. Conversely, activation of IKK attenuates the sensitization of melanoma by TRAF2ΔN, indicating that p38-mediated suppression of NF-κB activity is among TRAF2ΔN effects. Our finding identifies p38, TNFα and NF-κB among key players that efficiently sensitizes melanoma cells to UV-, ribotoxic (anisomycin) and radiomimetic chemicals-induced programmed cell death in response to aberrant TRAF2 signaling.
Evaluation of heat extraction through sapphire fibers for the GW observatory KAGRA
Creators: name: Khalaidovski, Alexander
name: Hofmann, Gerd
name: Chen, Dan
name: Komma, Julius
name: Schwarz, Christian
name: Tokoku, Chihiro
name: Kimura, Nobuhiro
name: Suzuki, Toshikazu
name: Scheie, Allen O.
name: Majorana, Ettore
name: Nawrodt, Ronny
name: Yamamoto, Kazuhiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Currently, the Japanese gravitational wave laser interferometer KAGRA is under construction in the Kamioka mine. As one main feature, it will employ sapphire mirrors operated at a temperature of 20K to reduce the impact from thermal noise. To reduce seismic noise, the mirrors will also be suspended from multi-stage pendulums. Thus the heat load deposited in the mirrors by absorption of the circulating laser light as well as heat load from thermal radiation will need to be extracted through the last suspension stage. This stage will consist of four thin sapphire fibers with larger heads necessary to connect the fibers to both the mirror and the upper stage. In this paper, we discuss heat conductivity measurements on different fiber candidates. While all fibers had a diameter of 1.6mm, different surface treatments and approaches to attach the heads were analyzed. Our measurements show that fibers fulfilling the basic KAGRA heat conductivity requirement of $κ\geq $5000W/m/K at 20K are technologically feasible.
description: 11 pages, 4 figures
Introduction: Animals, Ethics, and Enchantment in South Asia and the Middle East
Creators: name: Ahmed Asif, Manan
name: Taneja, Anand Vivek
Publisher: name: Columbia University
Year: 2015
Subjects: South Asians
History

description: Introduction to special journal issue "ANIMALS and ENCHANTMENT in SOUTH ASIA" for Comparative Studies of South Asia, Africa and the Middle East
Additional file 1 of Time series prediction of under-five mortality rates for Nigeria: comparative analysis of artificial neural networks, Holt-Winters exponential smoothing and autoregressive integrated moving average models
Creators: name: Adeyinka, Daniel Adedayo
name: Muhajarine, Nazeem
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1Table S1. Aggregated under-five mortality rates for Nigeria, 1964–2017.
An astronomical survey conducted in Belgium
Creators: name: Naze, Yael
name: Fontaine, Sebastien
Publisher: name: arXiv
Year: 2013
Subjects: subject: Physics Education (physics.ed-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: This article presents the results of the first survey conducted in Belgium about the interest and knowledge in astronomy. Two samples were studied, the public at large (667 questionnaires) and students (2589 questionnaires), but the results are generally similar in both samples. We evaluated people's interest, main information source, and attitudes towards astronomy, as well as their supposed and actual knowledge of the subject. The main conclusion is that, despite a poor self-confidence, people do know the basic astronomical concepts. However, that knowledge is not deeply rooted, as reasoning questions show well-spread misconceptions and/or misunderstandings.
description: accepted for publication by Physics Education
title: Compound Effects of Clock and Voltage Based Power Side-Channel Countermeasures
Creators: name: Lagasse, Jacqueline
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: The power side-channel attack, which allows an attacker to derive secret information from power traces, continues to be a major vulnerability in many critical systems. Numerous countermeasures have been proposed since its discovery as a serious vulnerability, including both hardware and software implementations. Each countermeasure has its own drawback, with some of the highly effective countermeasures incurring large overhead in area and power. In addition, many countermeasures are quite invasive to the design process, requiring modification of the design and therefore additional validation and testing to ensure its accuracy. Less invasive countermeasures that do not require directly modifying the system do exist but often offer less protection.
This thesis analyzes two non-invasive countermeasures and examines ways to maximize the protection offered by them while incurring the least amount of overhead. These two countermeasures are called clock phase noise (CPN) and voltage noise (VN), and are placed on the same FPGA as an AES encryption module that we are trying to protect. We test these designs against a highly effective algorithm called correlation power analysis (CPA) and a preprocessing technique called the sliding window attack (SW).
We found that the combined effects of the two countermeasures was greater than the impact of either countermeasure when used independently, and published a paper in the 2019 IEEE 30th International Conference on Application-specific Systems, Architectures and Processors (ASAP) on our findings. We found that our best combined countermeasure protected about 76% of the maximum amount of traces that a well-known but invasive competitor, wave dynamic differential logic (WDDL), could with only about 41% of the area and 78% of the power. However, the sliding window attack significantly reduced the amount of protection our combined countermeasure could offer to only 11% of that offered by WDDL. Since then, we updated our methodology and made some adjustments to VN and CPN. Our CPN countermeasure greatly improved, and therefore so did our combined countermeasure, which on average protected up to about 90% of the maximum amount of traces that WDDL could with only about 43% of the area and about 60% of the power. This is remarkable because these results are after the sliding window attack, meaning that our post-proposal countermeasures protect almost as well as WDDL while requiring only about half of the resources.
Evidence of 3D Dirac conical bands in TlBiSSe by optical and magneto-optical spectroscopy
Creators: name: Mardelé, F. Le
name: Wyzula, J.
name: Mohelsky, I.
name: Nasrallah, S.
name: Loh, M.
name: David, S. Ben
name: Toledano, O.
name: Tolj, D.
name: Novak, M.
name: Eguchi, G.
name: Paschen, S.
name: Barišić, N.
name: Chen, J.
name: Kimura, A.
name: Orlita, M.
name: Rukelj, Z.
name: Akrap, A.
name: Santos-Cottin, D.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: TlBiSSe is a rare realization of a 3D semimetal with a conically dispersing band that has an optical response which is well isolated from other contributions in a broad range of photon eneries. We report optical and magneto-optical spectroscopy on this material. When the compound is chemically tuned into a state of the lowest carrier concentration, we find a nearly linear frequency dependence of the optical conductivity below 0.5~eV. Landau level spectroscopy allows us to describe the system with a massive Dirac model, giving a gap $2Δ=32$~meV and an in-plane velocity parameter $v= 4.0\times 10^5$~m/s. % Finally, we provide a theoretical recipe to extract all parameters of the anisotropic Dirac band, including the Fermi energy and band degeneracy.
Evaluering af Etablering af samarbejdsfora mellem Centre for SeksueltMisbrugte og behandlingspsykiatri
Creators: Social- og Boligstyrelsen
Kristian Mark Bech Andersen
Publisher: name: Rigsarkivet
Year: 2023

description: Social- og Boligstyrelsen har gennemført evalueringen, der samler op på erfaringerne fra de tre samarbejdsfora. Evalueringen belyser bl.a. målopfyldelse, drivkræfter og barrierer og udbytte af samarbejdet. Evalueringen belyser særligt de erfaringer og pointer, som kan uddrages på tværs af de tre fora, selv om der ikke er tale om en fælles model på tværs af foraene, fordi de tre samarbejdsfora er forskellige i forhold til lokal organisering og udmøntning af samarbejdet.