cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Geburt durch telefonische Nachgespräche verarbeiten
Creators: name: Grylka, Susanne
name: Aeberli, Regula
name: Maute, Monique
name: Günthard, Barbara
name: Meier Käppeli, Barbara
name: Leutenegger, Vanessa
name: Pehlke-Milde, Jessica
Publisher: name: Schweizerischer Hebammenverband
Year: 2020
Subjects: Telefonisches Nachgespräch
Geburtsverarbeitung
Kontinuität in der Betreuung
618.4: Geburt

description: Frauen, die am UniversitätsSpital Zürich geboren hatten, schätzen es sehr, mit ihrer Hebamme in einem telefonischen Nachgespräch über die Geburt zu sprechen. Die Telefonate werden genutzt, um offene Fragen zum Geburtsverlauf zu klären, Rückmeldung zu negativen Erlebnissen zu geben sowie die Geburtsbetreuung abzuschliessen. Die meisten Frauen würden sich bei einer Folgegeburt wieder ein Nachgespräch wünschen. Das Angebot wurde von der Forschungsstelle Hebammenwissenschaft der Zürcher Hochschule für Angewandte Wissenschaften evaluiert.
Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing
Creators: name: Wallach, Thomas
name: Wetzel, Max
name: Dembny, Paul
name: Staszewski, Ori
name: Krüger, Christina
name: Buonfiglioli, Alice
name: Prinz, Marco
name: Lehnardt, Seija
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: microRNA
subject: toll-like receptor
subject: microglia
subject: neurons
subject: neurodegeneration
subject: small RNAsequencing
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Toll-like receptors (TLRs) belong to pattern recognition receptors, which respond to danger signals such as pathogen-associated molecular patterns or damage-associated molecular patterns. Upon TLR activation in microglia, the major immune cells in the brain, distinct signaling cascades trigger the production of inflammatory molecules, being a critical feature in neuroinflammation and neurodegenerative processes. Recently, individual microRNAs (miRNAs) were shown to act as endogenous TLR ligands. Here, we conducted systematic screening for miRNAs as potential TLR7/8 ligands by small RNA sequencing of apoptotic neurons and their corresponding supernatants. Several miRNA species were identified in both supernatants and injured neurons, and 83.3% of the media-enriched miRNAs activated murine and/or human TLR7/8 expressed in HEK293-derived TLR reporter cells. Among the detected extracellular miRNAs, distinct miRNAs such as miR-340-3p and miR-132-5p induced cytokine and chemokine release from microglia and triggered neurotoxicity in vitro. Taken together, our systematic study establishes miRNAs released from injured neurons as new TLR7/8 activators, which contribute to inflammatory and neurodegenerative responses in the central nervous system (CNS).
Two-dimensional simulations of coronal rain dynamics. I. Model with vertical magnetic field and an unbounded atmosphere
Creators: name: Martínez-Gómez, David
name: Oliver, Ramón
name: Khomenko, Elena
name: Collados, Manuel
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Aims. We aim to improve the understanding of the physical mechanisms behind the slower than free-fall motion and the two-stage evolution (an initial phase of acceleration followed by an almost constant velocity phase) detected in coronal rain events. Methods. Using the Mancha3D code, we solve the 2D ideal MHD equations. We represent the solar corona as an isothermal vertically stratified atmosphere with a uniform vertical magnetic field and the plasma condensation as a density enhancement described by a 2D Gaussian profile. We analyse the temporal evolution of the descending plasma and study its dependence on parameters such as density and magnetic field strength. Results. We confirm previous findings that the pressure gradient is the main force that opposes the action of gravity and slows down the blob descent and that larger densities require larger pressure gradients to reach the constant speed phase. We find that the shape of a condensation with a horizontal variation of density is distorted as it falls, due to the denser parts of the blob falling faster than the lighter ones. This is explained by the fact that the duration of the initial acceleration phase, and therefore the maximum falling speed attained by the plasma, increases with the ratio of blob to coronal density. We also find that the magnetic field plays a fundamental role in the evolution of the descending condensations. A strong enough magnetic field (greater than 10 G in our simulations) forces each plasma element to follow the path given by a particular field line, which allows to describe the evolution of each vertical slice of the blob in terms of 1D dynamics, without influence of the adjacent slices. In addition, under the typical conditions of the coronal rain events, the magnetic field prevents the development of the Kelvin-Helmholtz instability.
description: 14 pages, 11 figures; submitted to Astronomy & Astrophysics
Betreuen auf Distanz während des Lockdowns im Frühjahr 2020
Creators: name: Gemperle, Michael
name: Grylka, Susanne
name: Klamroth-Marganska, Verena
name: Ballmer, Thomas
name: Gantschnig, Brigitte E.
name: Pehlke-Milde, Jessica
Publisher: name: Schweizerischer Hebammenverband
Year: 2021
Subjects: Telehealth
Midwifery
Remote care
COVID-19
Perception
618: Geburtsmedizin und Hebammenarbeit

description: Das Betreuen auf Distanz, das in der Hebammenarbeit über lange Zeit keine besondere Aufmerksamkeit genoss, erhielt mit der COVID-19-Pandemie eine starke Beachtung. Eine Untersuchung der Zürcher Hochschule für angewandte Wissenschaften zeigt, welche konkreten Erfahrungen Hebammen damit während des ersten Lockdowns gemacht haben, und welche ungelösten Probleme mit im Spiel sind.
Intweetive Text Summarization
Creators: name: Cossu, Jean Valère
name: Torres-Moreno, Juan-Manuel
name: SanJuan, Eric
name: El-Bèze, Marc
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computation and Language (cs.CL)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: The amount of user generated contents from various social medias allows analyst to handle a wide view of conversations on several topics related to their business. Nevertheless keeping up-to-date with this amount of information is not humanly feasible. Automatic Summarization then provides an interesting mean to digest the dynamics and the mass volume of contents. In this paper, we address the issue of tweets summarization which remains scarcely explored. We propose to automatically generated summaries of Micro-Blogs conversations dealing with public figures E-Reputation. These summaries are generated using key-word queries or sample tweet and offer a focused view of the whole Micro-Blog network. Since state-of-the-art is lacking on this point we conduct and evaluate our experiments over the multilingual CLEF RepLab Topic-Detection dataset according to an experimental evaluation process.
description: 8 pages, 4 tables
Linee guida per l'implementazione di un sistema di monitoraggio delle politiche per prevenire e contrastare la violenza contro le donne. Seconda stesura
Creators: name: GAGLIARDI FRANCESCO
name: MOLTENI LORELLA
Publisher: name: Zenodo
Year: 2019

description: ABSTRACT (IT)
 Il rapporto presenta la seconda stesura della proposta di sistema di monitoraggio, finalizzato a verificare le realizzazioni e i risultati
 degli interventi finanziati dal Dipartimento per le Pari Opportunità della Presidenza del Consiglio a valere sia del Piano Strategico
 Nazionale sulla violenza maschile contro le donne 2017-20, sia della ripartizione delle risorse del “Fondo per le politiche relative ai
 diritti e alle pari opportunità” di cui all’articolo 5-bis, comma 1, del decreto legge 14 agosto 2013, n. 93, convertito con modificazioni
 nella legge 15 ottobre 2013, n. 119. ABSTRACT (EN) The document sets out the second draft of guidelines to help policy makers and advocates formulate effective monitoring system,
 aimed at verifying the achievements and results of the interventions financed by the Department for Equal Opportunities of the
 Presidency of the Council of Ministers. The proposal refers both to the National Strategic Plan on Men's violence against women
 2017-20, and to the “Allocation of the resources of the Fund for policies relating to rights and equal opportunities” provided by the
 Law 119/2013 (Article 5-bis).
description: DELIVERABLE N. 10 – GIUGNO 2019 Il progetto ViVa - Monitoraggio, Valutazione e Analisi degli interventi di prevenzione e contrasto alla violenza contro le donne è realizzato nell'ambito di un accordo di collaborazione tra IRPPS-CNR e Dipartimento per le Pari Opportunità della Presidenza del Consiglio dei Ministri. Il progetto prevede due principali livelli di azione:  il primo si concretizza nel supporto alle politiche di prevenzione e contrasto alla violenza sulle donne, attraverso un insieme di attività di ricerca-azione volte a sostenere il Dipartimento per le Pari Opportunità nell'attuazione del Piano Strategico Nazionale sulla violenza maschile contro le donne 2017–2020.  il secondo si sviluppa principalmente su un'analisi conoscitiva di tipo valutativo che riguarda tanto le dimensioni quantitative, quanto gli aspetti qualitativi della violenza nei confronti delle donne in Italia. È prevista una valutazione (ex post) dei processi attuativi, delle realizzazioni e dei risultati del Piano straordinario (2015-17) e ulteriori analisi valutative (ex-ante e in itinere) delle realizzazioni del Piano (2017–2020). Il progetto è realizzato dall'IRPPS-CNR ed è coordinato da Maura Misiti
The Difficulty of Symplectic Analysis with Second Class Systems
Creators: name: Shirzad, A.
name: Mojiri, M.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Using the basic concepts of chain by chain method we show that the symplectic analysis, which was claimed to be equivalent to the usual Dirac method, fails when second class constraints are present. We propose a modification in symplectic analysis that solves the problem.
description: 17 pages, no figure. accepted in JMP
Tomosvaryella demeyeri Kuznetzov 1993
Creators: name: Motamedinia, Behnam
name: Skevington, Jeffrey H.
name: Kelso, Scott
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Pipunculidae
Tomosvaryella
Tomosvaryella demeyeri

description: Tomosvaryella demeyeri Kuznetzov, 1993
Fig. 49
 Diagnosis: Following Kuznetzov (1993), this species can be recognized by the distinct ventrobasal protuberance of hind femur, bearing some distinct spines (Kuznetzov, 1993: fig. 13; Kehlmaier & Majnon-Jahromi, 2014: fig. 6); syntergosternite 8 with longitudinal suture in dorsal view (Kuznetzov, 1993: fig. 9); epandrium longer than wide (Kuznetzov, 1993: Fig. 18; Kehlmaier & Majnon-Jahromi, 2014: fig. 4); surstyli short, broadened in the middle and gradually tapering toward apices in dorsal view (Kuznetzov, 1993: fig. 18; Kehlmaier & Majnon-Jahromi, 2015: fig. 4); hypandrium with a distinct constriction after basal quarter (Kehlmaier & Majnon-Jahromi, 2015: fig. 3).
 Distribution: Egypt, Iran (Kuznetzov, 1993; Kehlmaier & Majnon Jahromi, 2015; Skevington 2020) (Fig. 49).
description: Published as part of Motamedinia, Behnam, Skevington, Jeffrey H. & Kelso, Scott, 2021, Revision of Tomosvaryella Aczél (Diptera: Pipunculidae) in the Middle East, with description of 19 new species, pp. 1-103 in Zootaxa 5002 (1) on pages 22-23, DOI: 10.11646/zootaxa.5002.1.1, http://zenodo.org/record/5122655
Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4
Creators: name: Antwi, Enoch B.
name: Olins, Ada
name: Teif, Vladimir B.
name: Bieg, Matthias
name: Bauer, Tobias
name: Gu, Zuguang
name: Brors, Benedikt
name: Eils, Roland
name: Olins, Donald
name: Ishaque, Naveed
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: DNA methylation
subject: Promyelocyte
subject: Differentiation
subject: Epigenomic regulation
subject: Long range interactions
subject: HL60
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Epigenomic regulation plays a vital role in cell differentiation. The leukemic HL-60/S4 [human myeloid leukemic cell line HL-60/S4 (ATCC CRL-3306)] promyelocytic cell can be easily differentiated from its undifferentiated promyelocyte state into neutrophil- and macrophage-like cell states. In this study, we present the underlying genome and epigenome architecture of HL-60/S4 through its differentiation. We performed whole-genome bisulphite sequencing of HL-60/S4 cells and their differentiated counterparts. With the support of karyotyping, we show that HL-60/S4 maintains a stable genome throughout differentiation. Analysis of differential Cytosine-phosphate-Guanine dinucleotide methylation reveals that most methylation changes occur in the macrophage-like state. Differential methylation of promoters was associated with immune-related terms. Key immune genes, CEBPA, GFI1, MAFB and GATA1 showed differential expression and methylation. However, we observed the strongest enrichment of methylation changes in enhancers and CTCF binding sites, implying that methylation plays a major role in large-scale transcriptional reprogramming and chromatin reorganisation during differentiation. Correlation of differential expression and distal methylation with support from chromatin capture experiments allowed us to identify putative proximal and long-range enhancers for a number of immune cell differentiation genes, including CEBPA and CCNF Integrating expression data, we present a model of HL-60/S4 differentiation in relation to the wider scope of myeloid differentiation.
Prostate Cancer Nodal Staging: Using Deep Learning to Predict 68Ga-PSMA-Positivity from CT Imaging Alone
Creators: name: Hartenstein, Alexander
name: Lübbe, Falk
name: Baur, Alexander D. J.
name: Rudolph, Madhuri M.
name: Furth, Christian
name: Brenner, Winfried
name: Amthauer, Holger
name: Hamm, Bernd
name: Makowski, Marcus
name: Penzkofer, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: prostate cancer (PCa)
subject: 68Ga-PSMA-PET/CT
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Lymphatic spread determines treatment decisions in prostate cancer (PCa) patients. 68Ga-PSMA-PET/CT can be performed, although cost remains high and availability is limited. Therefore, computed tomography (CT) continues to be the most used modality for PCa staging. We assessed if convolutional neural networks (CNNs) can be trained to determine 68Ga-PSMA-PET/CT-lymph node status from CT alone. In 549 patients with 68Ga-PSMA PET/CT imaging, 2616 lymph nodes were segmented. Using PET as a reference standard, three CNNs were trained. Training sets balanced for infiltration status, lymph node location and additionally, masked images, were used for training. CNNs were evaluated using a separate test set and performance was compared to radiologists' assessments and random forest classifiers. Heatmaps maps were used to identify the performance determining image regions. The CNNs performed with an Area-Under-the-Curve of 0.95 (status balanced) and 0.86 (location balanced, masked), compared to an AUC of 0.81 of experienced radiologists. Interestingly, CNNs used anatomical surroundings to increase their performance, "learning" the infiltration probabilities of anatomical locations. In conclusion, CNNs have the potential to build a well performing CT-based biomarker for lymph node metastases in PCa, with different types of class balancing strongly affecting CNN performance.
Unsupervised Sentiment Analysis for Code-mixed Data
Creators: name: Yadav, Siddharth
name: Chakraborty, Tanmoy
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Code-mixing is the practice of alternating between two or more languages. Mostly observed in multilingual societies, its occurrence is increasing and therefore its importance. A major part of sentiment analysis research has been monolingual, and most of them perform poorly on code-mixed text. In this work, we introduce methods that use different kinds of multilingual and cross-lingual embeddings to efficiently transfer knowledge from monolingual text to code-mixed text for sentiment analysis of code-mixed text. Our methods can handle code-mixed text through a zero-shot learning. Our methods beat state-of-the-art on English-Spanish code-mixed sentiment analysis by absolute 3\% F1-score. We are able to achieve 0.58 F1-score (without parallel corpus) and 0.62 F1-score (with parallel corpus) on the same benchmark in a zero-shot way as compared to 0.68 F1-score in supervised settings. Our code is publicly available.
Печеніги у Пороссі (територія та кількість населення)
Creators: name: Borysov, Artem
Publisher: name: figshare
Year: 2020
Subjects: Archaeology

description: Борисов, А. В. (2019). Печеніги у Пороссі (територія та кількість населення). Scientific Jornal Virtus, 38, 166–171

In the article, on the basis of the analysis of the natural environment, the territory of the Pechenegs‘ rolling of the 12th –the first half of the 13th century is localized. in Porossya Region. Based on the outlined territory of residence, the largest possible population of the Black Klobuks – Pechenegs of Ros` basin, was calculated. The paleoecological approach is used in the work. The maximum number of head of cattle in the herd is realized by the area of the territory and its productivity. The maximum number of nomadic population in the territory is calculated considering the minimum amount of livestock required for the survival of one person.
The Impact of Spinopelvic Mobility on Arthroplasty: Implications for Hip and Spine Surgeons
Creators: name: Haffer, Henryk
name: Adl Amini, Dominik
name: Perka, Carsten
name: Pumberger, Matthias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: total hip arthroplasty
subject: dislocation
subject: spine surgery
subject: spinopelvic alignment
subject: spondylodesis
subject: spinal fusion
subject: lumbar fusion
subject: spinal balance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Spinopelvic mobility represents the complex interaction of hip, pelvis, and spine. Understanding this interaction is relevant for both arthroplasty and spine surgeons, as a predicted increasing number of patients will suffer from hip and spinal pathologies simultaneously. We conducted a comprehensive literature review, defined the nomenclature, summarized the various classifications of spinopelvic mobility, and outlined the corresponding treatment algorithms. In addition, we developed a step-by-step workup for spinopelvic mobility and total hip arthroplasty (THA). Normal spinopelvic mobility changes from standing to sitting; the hip flexes, and the posterior pelvic tilt increases with a concomitant increase in acetabular anteversion and decreasing lumbar lordosis. Most classifications are based on a division of spinopelvic mobility based on ΔSS (sacral slope) into stiff, normal, and hypermobile, and a categorization of the sagittal spinal balance regarding pelvic incidence (PI) and lumbar lordosis (LL) mismatch (PI-LL = ± 10° balanced versus PI-LL > 10° unbalanced) and corresponding adjustment of the acetabular component implantation. When performing THA, patients with suspected pathologic spinopelvic mobility should be identified by medical history and examination, and a radiological evaluation (a.p. pelvis standing and lateral femur to L1 or C7 (if EOS (EOS imaging, Paris, France) is available), respectively, for standing and sitting radiographs) of spinopelvic parameters should be conducted in order to classify the patient and determine the appropriate treatment strategy. Spine surgeons, before planned spinal fusion in the presence of osteoarthritis of the hip, should consider a hip flexion contracture and inform the patient of an increased risk of complications with existing or planned THA.
Tomosvaryella dentiterebra
Creators: name: Motamedinia, Behnam
name: Skevington, Jeffrey H.
name: Kelso, Scott
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Pipunculidae
Tomosvaryella
Tomosvaryella dentiterebra

description: Tomosvaryella dentiterebra (Collin, 1949)
Figs 10A–E, 49
 Diagnosis: This species can be recognized by the asymmetrical shape of surstyli in dorsal view, left surstylus broadened apically and constricted medially, right surstylus broader than left one basally (Fig. 10A); epandrium wider than long in dorsal view (Fig. 10A); gonopods unequal in height, left is higher than right one in ventral view (Fig. 10B); phallus trifid, with three wavy ejaculatory ducts, one with tooth-like projections in basal half in lateral view (Fig. 10D–E). Based on the shape of the surstyli in dorsal view, it is closely related to T. angolensis De Meyer, 1993 and T. forchhammeri De Meyer, 1993. It differs from these species by the shape of the left surstylus in dorsal view, constricted in the middle (Fig. 10A).
 Specimens examined: UNITED ARAB EMIRATES: Bithnah, 25°06’N, 56°08’E, 12.viii–9.ix.2006, A. van Harten, Malaise trap, CNCD 160279 (1♂, CNC); Sharjah Desert Park, 25°10’N, 55°25’E, 4–8.xii.2004, A. van Harten, pan trap, CNCD 4277 (1♂, CNC); Um al-Quwain, 25°19’N, 55°19’E, 23–26.vi.2008, A. van Harten, pan trap, JSS52251 (1♂, CNC); Wadi Bih dam, 25°48’N, 56°04’E, 21–30.iv.2008, A. van Harten, light trap, JSS52243 (1♂, CNC); Wadi Bih, 25°29’N, 56°02’E, 29.iii.2007, F. Menzel, sweep net, CNCD 159626 (1♂, TAU); Wadi Maidaq, 25°11’N, 56°04’E, 29.vii–26.viii.2006, A. van Harten, Malaise trap, CNCD 159901 (1♂, EAD).
 Distribution: Egypt, Iran, United Arab Emirates (Skevington 2020) (Fig. 49).
description: Published as part of Motamedinia, Behnam, Skevington, Jeffrey H. & Kelso, Scott, 2021, Revision of Tomosvaryella Aczél (Diptera: Pipunculidae) in the Middle East, with description of 19 new species, pp. 1-103 in Zootaxa 5002 (1) on pages 24-25, DOI: 10.11646/zootaxa.5002.1.1, http://zenodo.org/record/5122655
Additional file 4 of MiR-937-3p promotes metastasis and angiogenesis and is activated by MYC in lung adenocarcinoma
Creators: name: Ma, Zijian
name: Chen, Ganyi
name: Chen, Yiqian
name: Guo, Zizhang
name: Chai, Hao
name: Tang, Yu
name: Zheng, Lin
name: Wei, Ke
name: Pan, Chunfeng
name: Ma, Zhifei
name: Xia, Yang
name: Zhang, Aiping
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 4: Table S1. Sequences of the primers in this study.
2019_borysov_009.pdf
Creators: name: Borysov, Artem
Publisher: name: figshare
Year: 2020
Subjects: Archaeology

description: Борисов А.В. Печеніги у Пороссі (територія та кількість населення). Scientific Jornal Virtus. November #38, 2019. s.166-171

In the article, on the basis of the analysis of the natural environment, the territory of the Pechenegs‘ rolling of the 12th –the first half of the 13th century is localized. in Porossya Region. Based on the outlined territory of residence, the largest possible population of the Black Klobuks – Pechenegs of Ros` basin, was calculated. The paleoecological approach is used in the work. The maximum number of head of cattle in the herd is realized by the area of the territory and its productivity. The maximum number of nomadic population in the territory is calculated considering the minimum amount of livestock required for the survival of one person.
Interdisziplinäre Zusammenarbeit im Bereich der frühen Förderung
Creators: name: Pehlke-Milde, Jessica
name: Erdin Springer, Rebekka
name: Radu, Irina
name: Grylka, Susanne
name: Krahl, Astrid
Publisher: name: Schweizerischer Hebammenverband
Year: 2018
Subjects: Interdisziplinäre Zusammenarbeit
Frühe Förderung
Hebammen
362: Gesundheits- und Sozialdienste
618: Geburtsmedizin und Hebammenarbeit

description: Eine Studie der Zürcher Hochschule für Angewandte Wissenschaften zeigt, dass Hebammen soziale Belastungen in den Familien erkennen und Sorge dafür tragen, dass die Familien mit Neugeborenen im Zugang zu weiterführenden Angeboten der Frühen Förderung unterstützt werden. Die damit verbundene intra- und interdisziplinäre Vernetzung wird fallbezogen wie auch in Netzwerken erbracht.
Environment-Specific Probiotic Supernatants Modify the Metabolic Activity and Survival of Streptococcus mutans in vitro
Creators: name: Yu, Haiyue
name: Ganas, Petra
name: Schwendicke, Falk
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: caries
subject: colony forming units
subject: dental
subject: lactate production
subject: metabolites
subject: probiotics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: A range of studies showed probiotics like Streptococcus oligofermentans and Limosilactobacillus reuteri to inhibit the cariogenic activity and survival of Streptococcus mutans, possibly via the production of substances like H2O2, reuterin, ammonia and organic acids. We aimed to assess the environment-specific mechanisms underlying this inhibition. We cultured L. reuteri and S. oligofermentans in various environments; minimal medium (MM), MM containing glucose (MM+Glu), glycerol (MM+Gly), lactic acid (MM+Lac), arginine (MM+Arg) and all four substances (MM+all) in vitro. Culture supernatants were obtained and metabolite concentrations (reuterin, ammonia, H2O2, lactate) measured. S. mutans was similarly cultivated in the above six different MM variation media, with glucose being additionally added to the MM+Gly, MM+Lac, and MM+Arg group, with (test groups) and without (control groups) the addition of the supernatants of the described probiotic cultures. Lactate production by S. mutans was measured and its survival (as colony-forming-units/mL) assessed. L. reuteri environment-specifically produced reuterin, H2O2, ammonia and lactate, as did S. oligofermentans. When cultured in S. oligofermentans supernatants, lactate production by S. mutans was significantly reduced (p < 0.01), especially in MM+Lac+Glu and MM+all, with no detectable lactate production at all (controls means ± SD: 4.46 ± 0.41 mM and 6.00 ± 0.29 mM, respectively, p < 0.001). A similar reduction in lactate production was found when S. mutans was cultured in L. reuteri supernatants (p < 0.05) for all groups except MM+Lac+Glu. Survival of S. mutans cultured in S. oligofermentans supernatants in MM+Lac+Glu and MM+all was significantly reduced by 0.6-log10 and 0.5-log10, respectively. Treatment with the supernatant of L. reuteri resulted in a reduction in the viability of S. mutans in MM+Gly+Glu and MM+all by 6.1-log10 and 7.1-log10, respectively. Probiotic effects on the metabolic activity and survival of S. mutans were environment-specific through different pathways.
The detection of stellar velocity dispersion drops in the central regions of five isolated Seyfert spirals
Creators: name: Marquez, I.
name: Masegosa, J.
name: Durret, F.
name: Delgado, R. M. Gonzalez
name: Moles, M.
name: Maza, J.
name: Perez, E.
name: Roth, M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyze the kinematics of the central regions of five isolated Seyfert spiral galaxies from the DEGAS sample (four with new data presented in this paper, IC184, UGC3223, NGC2639, NGC6814, and NGC6951 from our previous data), by using long slit spectroscopy in the CaII triplet range (at ~ 8600 A) obtained with a 4m-class telescope. A drop of the velocity dispersions in the innermost 1-3 arcsec is observed in four of them, and hinted in the remaining galaxy (NGC6814). The available HST images for our sample together with another nine galaxies with reported velocity dispersion drops, are also used to investigate the presence of morphological inner structures at the scales of the kinematical drops. Evidence for disk-like shapes is found in 12 out of the 14 cases. The only exceptions are NGC6814 and NGC6951. Existing N-body simulations including stars, gas and star formation predict that such a drop is most probably due to a young stellar population born from dynamically cold gas accreted in a circumnuclear disk formed during an episode of central gas accretion driven by a bar. The equivalent widths of the Calcium triplet lines for our 5 galaxies have been measured. Even if the profiles could be formally consistent with constant EW(CaT) values, they seem to indicate the presence of a local maximum in the regions corresponding spatially to the drops; if confirmed, this would imply the presence of a different stellar population, whose properties could help constraining the models.
description: A&A accepted for publication
A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells
Creators: name: Kobold, Sabine
name: Guhr, Anke
name: Mah, Nancy
name: Bultjer, Nils
name: Seltmann, Stefanie
name: Seiler Wulczyn, Andrea E. M.
name: Stacey, Glyn
name: Jie, Hao
name: Liu, Wang
name: Löser, Peter
name: Kurtz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: pluripotent stem cell
subject: clinical study database
subject: mbryonic stem cell
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The last 5 years have witnessed a significant increase in the number of clinical studies based on human pluripotent stem cells (hPSCs). In parallel, concern is increasing about the proliferation of unregulated stem cell treatments worldwide. Regulated clinical testing is a de facto standard to establish the safety and efficacy of new cell therapies, yet reliable information on clinical studies involving hPSCs is scattered. Our analysis of a multitude of resources found 54 clinical studies involving several types of hPSCs, which are performed in ten countries. While the majority of those studies is based on human embryonic stem cells (hESCs), clinical studies involving human induced pluripotent stem cells increased more strongly in the past 2 years than the number of hESC-based studies. A publicly accessible database was created using the human pluripotent stem cell registry (https://hpscreg.eu) platform, providing a steadily updated comprehensive overview on hPSC-based clinical studies performed worldwide.
Graft preservation with multi-stage surgical repair of an aortoesophageal fistula after thoracic endovascular aortic repair - A case report
Creators: name: Buerger, Matthias
name: Frese, Jan Paul
name: Kapahnke, Sebastian
name: Greiner, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Aortoesophageal fistula
subject: Thoracoabdominal aorta
subject: TEVAR
subject: Graft infectiona
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Aortoesophageal fistula (AEF) after thoracic endovascular aortic repair (TEVAR) is a rare complication associated with high mortality. Most well established treatment is multi-staged surgery, including removal of infected stent graft, esophageal resection and aortic reconstruction. Presentation of case: We report on a case of a 67-year-old patient with AEF and stent graft infection. Stent removal was infeasible due to the critical condition of the patient and history of multiple vascular procedures of the thoracoabdominal aorta. Surgical management included staged right and left thoracotomy, esophagectomy, vacuum therapy (VAC) on stent prosthesis and subsequent graft coverage with omental and pleural flaps, followed by esophageal reconstruction. Discussion: An established and generally accepted treatment approach for graft infections does not exist. Graft explantation and radical surgical debridement is the therapy of choice for prosthetic infections. In comparison to previous literature, our case represents the complexity of the treatment of AEF and its enormous demands on the interdisciplinary medical team. Conclusion: Our report shows that in an emergency situation without other surgical options as in our case, it was possible to stabilize the patient through application of vacuum therapy in the infected area, with simultaneous esophagectomy, followed by secondary staged reconstruction with omentoplasty and pleura parietalis flap remaining the graft in situ.
title: The adaptation of the Short Dark Triad personality measure
title: psychometric properties of a German sample
titleType: Subtitle
Creators: name: Malesza, Marta
name: Ostaszewski, Paweł
name: Büchner, Susanne
name: Kaczmarek, Magdalena Claudia
Publisher: name: Universität Potsdam
Year: 2019

description: This research was designed to adapt and investigate the psychometric properties of the Short Dark Triad measure (Jones and Paulhus Assessment, 21(1), 28-41, 2014) in a German sample within four studies (total N = 1463); the measure evaluates three personality dimensions: narcissism, psychopathy, and Machiavellianism. The structure of the instrument was analysed by Confirmatory Factor Analyses procedure. It indicated that the three-factor structure had the best fit to the data. Next, the Short Dark Triad measure was evaluated in terms of construct, convergent and discriminant validity, internal consistency (≥ .72), and test-retest reliability during a 4-week period (≥ .73). Concurrent validity of the SD3 was supported by relating its subscales to measures of the Big Five concept, aggression, and self-esteem. We concluded that the Short Dark Triad instrument presented high cross-language replicability. The use of this short inventory in the investigation of the Dark Triad personality model in the German language context is suggested.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 555
Cosmological models from a geometric point of view
Creators: name: MacCallum, M. A. H.
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: (There is no original abstract.) These are lecture notes from a 1971 summer school surveying the then known cosmological models in particular the properties of Bianchi cosmologies, and giving a pedagogical introduction to groups of isometries in spacetime and to the orthonormal tetrad method.
description: These notes have been widely cited, but were not readily available. The copyright is held by Taylor and Francis who now own Gordon and Breach and whose permission must be sought for any uses demanding copyright. They have given permission for posting to archives, for which I am grateful, saying "Given that the material was pre-digital you are permitted to scan and post the printed original."
Forms of inquiry-based science instruction and their relations with learning outcomes: evidence from high and low-performing education systems
Creators: name: Anindito Aditomo
name: Klieme, Eckhard
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Inquiry-based science instruction is widely advocated, but studies based on international large-scale assessments often show inquiry to be negatively associated with achievement. We re-examine this issue by examining whether the association between inquiry and learning depends upon the provision of teacher guidance. Participants were 151,721 students from 5089 schools from 10 highest and 10 lowest science performers in PISA 2015. Multi-group confirmatory factor analyses found that measurement invariance cannot be established, suggesting substantial regional variation in the pattern of inquiry-based instruction. Nonetheless, exploratory factor analyses indicated that at the conceptual level, many regions exhibit a pattern which contrasted between ‘Guided inquiry’ and ‘Independent inquiry’. Results of structural equation modelling showed that inquiry is positively associated with outcomes when it incorporates teacher guidance, and negatively when it doesn’t. However, the strength of the positive associations is stronger in regions where guided inquiry is measured with fewer items referring to student-centred activities. These findings are in line with current theories regarding the importance of scaffolding in learning from inquiry. This study suggests that it would be misguided to use PISA findings to support arguments to scale back inquiry and other constructivist approaches to teaching science.
Nonlinear performance of asymmetric coupler based on dual-core photonic crystal fiber: towards sub-nanojoule solitonic ultrafast all-optical switching
Creators: name: Curilla, L.
name: Astrauskas, I.
name: Pugzlys, A.
name: Stajanca, P.
name: Pysz, D.
name: Uherek, F.
name: Baltuska, A.
name: Bugar, I.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate ultrafast soliton-based nonlinear balancing of dual-core asymmetry in highly nonlinear photonic crystal fiber at sub-nanojoule pulse energy level. The effect of fiber asymmetry was studied experimentally by selective excitation and monitoring of individual fiber cores at different wavelengths between 1500 nm and 1800 nm. Higher energy transfer rate to non-excited core was observed in the case of fast core excitation due to nonlinear asymmetry balancing of temporal solitons, which was confirmed by the dedicated numerical simulations based on the coupled generalized nonlinear Schrödinger equations. Moreover, the simulation results correspond qualitatively with the experimentally acquired dependences of the output dual-core extinction ratio on excitation energy and wavelength. In the case of 1800 nm fast core excitation, narrow band spectral intensity switching between the output channels was registered with contrast of 23 dB. The switching was achieved by the change of the excitation pulse energy in sub-nanojoule region. The performed detailed analysis of the nonlinear balancing of dual-core asymmetry in solitonic propagation regime opens new perspectives for the development of ultrafast nonlinear all-optical switching devices.
description: 19 pages, 9 figures
First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects - a cohort study
Creators: name: Hamann, Lutz
name: Szwed, Malgorzata
name: Mossakowska, Malgorzata
name: Chudek, Jerzy
name: Puzianowska-Kuznicka, Monika
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Inflamm-aging
subject: Obesity
subject: STING
subject: Polymorphism
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Obesity is a risk factor for several aging-related diseases such as type 2 diabetes, cardiovascular disease, and cancer. Especially, cardiovascular disease is triggered by obesity by inducing vascular senescence and chronic low-grade systemic inflammation, also known as inflamm-aging. Released molecules from damaged cells and their recognition by the innate immune system is one of the mechanisms driving inflamm-aging. Obesity results in mitochondrial damage, leading to endothelial inflammation triggered by cytosolic mtDNA via the cGAS/STING pathway. Recently, we have shown STING SNP R293Q to be associated with a decreased risk for aging-related diseases in current smokers. Since current smoking triggers DNA damage that, similar to obesity, may result in the release of DNA into the cytoplasm, we hypothesized that the cGAS/STING pathway can modify the phenotype of aging also in obese subjects. Therefore, the objective of our study was to investigate whether STING R293Q is associated with aging-related diseases in obese individuals. We indeed show that STING 293Q is associated with protection from combined aging-related diseases (P = 0.014) and, in particular, cardiovascular disease in these subjects (P = 0.010). Therefore, we provide the first evidence that stratification for obesity may reveal new genetic loci determining the risk for aging-related diseases.
Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions
Creators: name: Wu, Jun-Yong
name: Li, Yong-Jiang
name: Xiong-Bin Hu
name: Huang, Si
name: Da-Xiong Xiang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 60506 Virology

description: Extracellular vesicles (EVs) are nanovesicles involved in multiple biological functions. Small EVs (sEVs) are emerging as therapeutics and drug delivery systems for their contents, natural carrier properties, and nanoscale size. Despite various clinical application potentials, little is known about the effects of storage conditions on sEVs for functional analysis and therapeutic use. In this study, we evaluated the stability of sEVs stored at 4 °C, −20 °C, and −80 °C up to 28 days and compared them to fresh sEVs. Also, the effect of freeze-thawing circles on the quantity of sEVs was assessed. We found that different storage temperatures, along with shelf life, impact the stability of sEVs when compared to freshly isolated sEVs. Storage changes the size distribution, decreases quantity and contents, and impacts cellular uptake and biodistribution of sEVs. For functional studies, isolated sEVs are suggested to be analyzed freshly or stored at 4 °C or −20 °C for short-term preservation depending on study design; but −80 °C condition would be more preferable for long-term preservation of sEVs for therapeutic application.
The first composite score predicting Digital Ulcers in systemic sclerosis patients using Clinical data, Imaging and Patient history-CIP-DUS
Creators: name: Friedrich, S.
name: Lüders, S.
name: Klotsche, J.
name: Burmester, G. R.
name: Riemekasten, G.
name: Ohrndorf, S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Systemic sclerosis
subject: Capillaroscopy
subject: Colour Doppler ultrasound
subject: Fluorescence optical imaging
subject: Modified Rodnan skin score
subject: Disturbed microcirculation
subject: Digital ulcers
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Digital ulcers (DU) present a challenging complication in systemic sclerosis (SSc). The aim of this study was to combine clinical characteristics and imaging methods to a composite score for the prediction of DU in SSc patients. Methods: Seventy-nine SSc patients received clinical examination, their patient history was taken and nailfold capillaroscopy (NC), colour Doppler ultrasonography (CDUS) and fluorescence optical imaging (FOI) of the hands were performed at baseline. Newly developed DU over a period of approximately 12 months were registered. We used criteria with area under the curve (AUC) of at least 0.6 in regard to the development of these new DU to create the score (CIP-DUS, clinical features, imaging, patient history-digital ulcer score). Results: Twenty-nine percent of all SSc patients developed new DU during follow-up (48.1% diffuse, 18.4% limited SSc). Based on the cross-validated (cv) AUC, a weight (cvAUC > 0.6 and ≤ 0.65: 1; cvAUC > 0.65 and ≤ 0.7: 2; cvAUC > 0.7: 3) was assigned to each selected parameter. The performance of the final CIP-DUS was assessed with and without the CDUS/FOI component. For the scleroderma patterns in NC, three points were appointed to late, two to active and one point to early capillaroscopy pattern according to Cutolo et al. The CIP-DUS including the CDUS and FOI parameters resulted in a good diagnostic performance (AUC after cross-validation: 0.83, 95%CI 0.74 to 0.92) and was well calibrated (chi-square = 12.3, p = 0.58). The cut-off associated with the maximum of sensitivity and specificity was estimated at ≥ 10 points resulting in a sensitivity of 100% and specificity of 74% for new DU during follow-up. Excluding CDUS and FOI parameters leads to a non-statistically significant lower performance (AUC after cross-validation: 0.81, 95%CI 0.72 to 0.91). However, including CDUS and FOI resulted in a better classification of patients in respect to the outcome new DU in follow-up due to significantly better reclassification performance (NRI = 62.1, p = 0.001) and discrimination improvement (IDI = 9.7, p = 0.01). Conclusion: A new score was introduced with the aim to predict digital ulcers. If applied correctly and with the new imaging techniques proposed, all patients at risk of digital ulcers throughout 12 months could be identified.
The D*0 D0bar threshold resonance
Creators: name: Close, Frank E.
name: Page, Philip R.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Tests are discussed to distinguish c cbar, hybrid charmonium and molecular interpretations of the narrow Belle resonance at 3872 MeV.
description: 8 pages, LaTeX. Details about pi exchange in molecule added
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease
Creators: name: Yalçin, Müge
name: El-Athman, Rukeia
name: Ouk, Koliane
name: Priller, Josef
name: Relógio, Angela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: circadian clock
subject: colorectal cancer
subject: drug targets
subject: high-throughput time course data
subject: Huntington’s disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Accumulating evidence points to a link between circadian clock dysfunction and the molecular events that drive tumorigenesis. Here, we investigated the connection between the circadian clock and the hallmarks of cancer in an in vitro model of colorectal cancer (CRC). We used a cross-platform data normalization method to concatenate and compare available microarray and RNA-sequencing time series data of CRC cell lines derived from the same patient at different disease stages. Our data analysis suggests differential regulation of molecular pathways between the CRC cells and identifies several of the circadian and likely clock-controlled genes (CCGs) as cancer hallmarks and circadian drug targets. Notably, we found links of the CCGs to Huntington's disease (HD) in the metastasis-derived cells. We then investigated the impact of perturbations of our candidate genes in a cohort of 439 patients with colon adenocarcinoma retrieved from the Cancer Genome Atlas (TCGA). The analysis revealed a correlation of the differential expression levels of the candidate genes with the survival of patients. Thus, our study provides a bioinformatics workflow that allows for a comprehensive analysis of circadian properties at different stages of colorectal cancer, and identifies a new association between cancer and HD.