cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Precise Data Identification Services for Long Tail Research Data
Creators: name: Proell, Stefan
name: Meixner, Kristof
name: Rauber, Andreas
Publisher: name: figshare
Year: 2016
Subjects: subject: 80708 Records and Information Management (excl. Business Records and Information Management)
subject: FOS: Media and communications
subject: Library and Information Studies

description: While sophisticated research infrastructures assist scientists
in managing massive volumes of data, the so-called long tail
of research data frequently suffers from a lack of such ser-
vices. This is mostly due to the complexity caused by the va-
riety of data to be managed and a lack of easily standardise-
able procedures in highly diverse research settings. Yet, as
even domains in this long tail of research data are increas-
ingly data-driven, scientists need efficient means to precisely
communicate, which version and subset of data was used in a
particular study to enable reproducibility and comparability
of result and foster data re-use.
This paper presents three implementations of systems sup-
porting such data identification services for comma sepa-
rated value (CSV) files, a dominant format for data ex-
change in these settings. The implementations are based
on the recommendations of the Working Group on Dynamic
Data Citation of the Research Data Alliance (RDA). They
provide implicit change tracking of all data modifications,
while precise subsets are identified via the respective subset-
ting process. These enhances reproducibility of experiments
and allows efficient sharing of specific subsets of data even
in highly dynamic data settings
Stature, Skills and Adult Life Outcomes: Evidence from Indonesia
Creators: name: Bargain, Olivier
name: Zeidan, Jinan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We investigate the effect of height on earnings, occupational choices and a subjective measure of wellbeing among Indonesian men. We explore the extent to which height captures the effects of endowments set before entry in the labour market. Physical and cognitive skills, co-determined with stature early in life, do not explain much of the height earnings premium directly. Yet, human capital more broadly, including cognition, educational attainment and other factors related to childhood conditions, explains around half of the height premium and does so through occupational sorting. Indeed, taller workers tend to have more education, and educated workers tend to work in more lucrative occupations that require brain and social skills, not brawn. The unexplained share of the height earnings premium may reflect a specific role of stature on social interaction, labour market advantages or self-assurance. We also find a height premium in happiness, half of which simply accounts for the educational and earnings advantages of taller workers.
Peak effect in a superconductor/normal metal strip being in vortex-free state
Creators: name: Marychev, P. M.
name: Vodolazov, D. Yu.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We theoretically predict that the critical current $I_c$ and magnetization $M$ of hybrid superconductor/normal-metal (SN) strip may have nonmonotonous dependence on perpendicular magnetic field - so called peak effect. In contrast to familiar peak effect, which is connected either with vortex entry to the superconductor or with peculiarities of vortex pinning, the found phenomenon exists at low fields, in the vortex-free (Meissner) phase. We argue that the effect appears at specific parameters of studied hybrid structure when its in-plane current-supervelocity relation has two maxima. We expect that the same peak effect may exist in two-band superconductors (like MgB$_2$) where similar current-supervelocity dependence was predicted at low temperatures.
description: 5 pages, 3 figures
Arterial stiffness is not increased in patients with short duration rheumatoid arthritis and ankylosing spondylitis
Creators: name: Dzieża-Grudnik, Anna
name: Sulicka, Joanna
name: Strach, Magdalena
name: Siga, Olga
name: Klimek, Ewa
name: Korkosz, Mariusz
name: Grodzicki, Tomasz
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have increased cardiovascular (CV) morbidity and mortality. Arterial stiffness is an independent predictor of CV events. The aim of the study was to assess arterial stiffness and inflammatory markers in patients with short duration chronic arthritis. We assessed carotid-femoral pulse wave velocity (PWV), augmentation index (AIx), traditional CV risk factors and inflammatory and endothelial markers in 71 chronic arthritis patients (RA and AS) and in 29 healthy controls. We did not find differences in PWV (for RA, AS and controls, respectively: 10 [8.8–10.9] versus 10.7 [9.1–11.8] versus 9.2 [8.3–11.4] m/s; p = .14) and AIx (for RA, AS and controls, respectively: 24.3 ± 11.5 versus 5.7 ± 12.4 versus 10 ± 12.8%; p = .22). Both groups of arthritis patients had active disease with significantly elevated inflammatory markers compared to controls. There were no correlations between endothelial and inflammatory markers and parameters of arterial stiffness in arthritis patients. When analyzing arthritis patients according to median of PVW, there were no significant differences in inflammatory and endothelial markers. We found that in patients with short duration active RA and AS arterial stiffness was not increased and furthermore, there was no association between markers of systemic inflammation and arterial stiffness.
Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants
Creators: name: Frei, Lester
name: Gao, Beichen
name: Han, Jiami
name: Taft, Joseph M.
name: Irvine, Edward B.
name: Weber, Cédric
name: Kumar, Rachita
name: Eisinger, Benedikt N.
name: Reddy, Sai T.
Publisher: name: ETH Zurich
Year: 2023

description: Most COVID-19 antibody therapies rely on binding the SARS-CoV-2 receptor binding domain (RBD). However, heavily mutated variants such as Omicron and its sublineages, which are characterized by an ever increasing number of mutations in the RBD, have rendered prior antibody therapies ineffective, leaving no clinically approved antibody treatments for SARS-CoV-2. Therefore, the capacity of therapeutic antibody candidates to bind and neutralize current and prospective SARS-CoV-2 variants is a critical factor for drug development. Here, we present a deep learning-guided approach to identify antibodies with enhanced resistance to SARS-CoV-2 evolution. We apply deep mutational learning (DML), a machine learning-guided protein engineering method to interrogate a massive sequence space of combinatorial RBD mutations and predict their impact on angiotensin-converting enzyme 2 (ACE2) binding and antibody escape. A high mutational distance library was constructed based on the full-length RBD of Omicron BA.1, which was experimentally screened for binding to the ACE2 receptor or neutralizing antibodies, followed by deep sequencing. The resulting data was used to train ensemble deep learning models that could accurately predict binding or escape for a panel of therapeutic antibody candidates targeting diverse RBD epitopes. Furthermore, antibody breadth was assessed by predicting binding or escape to synthetic lineages that represent millions of sequences generated using in silico evolution, revealing combinations with complementary and enhanced resistance to viral evolution. This deep learning approach may enable the design of next-generation antibody therapies that remain effective against future SARS-CoV-2 variants.
description: bioRxiv
Effects of external pressure on the narrow gap semiconductor Ce$_{3}$Cd$_{2}$As$_{6}$
Creators: name: Piva, M. M.
name: Xiang, L.
name: Thompson, J. D.
name: Bud'ko, S. L.
name: Ribeiro, R. A.
name: Canfield, P. C.
name: Rosa, P. F. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Here we report the magnetic and electronic properties of recently discovered Ce$_{3}$Cd$_{2}$As$_{6}$. At ambient pressure, Ce$_{3}$Cd$_{2}$As$_{6}$ presents a semiconducting behavior with an activation gap of 74(1)~meV. At 136~K, a sudden increase of the electrical resistivity and a peak in specific heat are consistent with a charge density wave transition. At low temperatures, antiferromagnetic order of the Ce$^{3+}$ ions occurs below $T_{\rm N} = 4.0$~K with a magnetic hard axis along the $c$-axis and a $Γ_{6} = |\pm1/2\rangle$ doublet ground state. The application of external pressure strongly suppresses the charge density wave order, which is completely suppressed above 0.8(1)~GPa, and induces a metallic ground state. No evidence for superconductivity is detected above 2~K. Conversely, the antiferromagnetic state is favored by pressure, reaching a transition temperature of 5.3~K at 3.8(1)~GPa. Notably, the resistivity anomaly characterizing the antiferromagnetic order changes with increasing pressure, indicating that two different magnetic phases might be present in Ce$_{3}$Cd$_{2}$As$_{6}$ under pressure. This change in ordering appears to be associated to the crossing of the $T_{\rm CDW}$ and $T_{\rm N}$ lines.
Bioactive new metabolites from the green alga Udotea orientalis growing on the Gorgonian coral Pseudopterogorgia rigida
Creators: name: Sabry, Omar M. M.
name: Goeger, Douglas E.
name: Gerwick, William H.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: As part of our continued search for bioactive secondary metabolites from marine sources using a bioassay-guided fractionation technique (Cytotoxic and anti-trypanosome activities), we have examined the organic extract of Papua New Guinean collection of the green alga Udotea orientalis growing on the Gorgonian coral Pseudopterogorgia rigida. Successive HPLC investigations resulted in isolation of three new compounds, (+) curcuepoxide A, (+) curcuepoxide B and (+)-10α-hydroxycurcudiol. Analysis of different spectroscopic data e.g. UV, IR, LRMS, HRMS, 1D NMR and 2D NMR on the isolated compounds allowed for construction of the planar structures. Stereochemistry assignment at C-7 and C-10 in the new compounds was discussed. Isolated compounds were found to be active in an in vitro assay of antitrypanosome activity. The isolated compounds were found to have variable cytotoxic activity in human lung cancer cell lines.
Inter- and Transdisciplinary research in Integrated Water Resources Management: insights from a case study in Tandil, Buenos Aires, Argentina
Creators: name: Villalba, Luciano
name: Vienni Baptista, Bianca
Publisher: name: ETH Zurich
Year: 2022
Subjects: water management
Transdisciplinary research
Latin America

description: While integrated water governance approaches, such as Integrated Water Resources Management (IWRM), are constantly promoted in the sustainability agenda, they face several challenges, especially in developing countries, where monetary resources are scarce and socioeconomic contexts are unstable. Moreover, the baseline is often a problematic but resilient configuration of a complex system, which calls for inter- and transdisciplinary (ID and TD) research. However, the adoption of these approaches for IWRM implementation is still limited, while their use to analyse IWRM past experiences is even less frequent. In this article, we use the TD heuristic framework developed by Vienni-Baptita et al. (2022) to study a series of IWRM workshops conducted in Tandil, Argentina. Our results show that methodological weakness can excessively extend the problem-framing phase, conditioning the process outputs. Regarding actors, our analysis suggests that the engagement of citizens is not only ethically relevant, but may be crucial to impulse the actions needed to foster IWRM.
description: WATERLAT-GOBACIT Network working papers, 9 (3)
description: ISSN:2056-4864
description: ISSN:2056-4856
description: Producing knowledge about Water. Theoretical and methodological controversies, flows, meanders, rigidities, and the pursuit of “full transdiciplinarity”
Essential oil composition of Ajuga comata Stapf. from Southern Zagros, Iran
Creators: name: Karami, Akbar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The chemical composition of essential oil obtained from the aerial parts of Ajuga comata Stapf. was analyzed by GC and GC/MS. Thirty-seven components were identified in the oil. (E)-β-caryophyllene (30.9%), caryophyllene oxide (24.9%), (E)-β-farnesene (12.6%), β-eudesmol (3.2%), δ-cadinene (3.1%) and germacrene D (3.0%) were the main compounds in the EOs. The chemical composition of A. comata Stapf. from the Southern Zagros of Iran is reported for the first time.
Does nest placement in buildings influence nest predation in red-billed choughs?
Creators: name: Banda, Eva
name: Blanco, Guillermo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Factors determining nest predation are often multiple and spatiotemporally variable. We evaluated the relative importance of nest placement on predation risk of red-billed choughs (Pyrrhocorax pyrrhocorax) nesting in abandoned buildings in north-eastern Spain, while controlling for other potentially influential social, population and landscape variables at several spatial scales. Data from 705 breeding attempts belonging to 405 different pairs nesting in 342 different buildings were obtained in three breeding seasons. Nest predation was the main cause of reproductive failure. Breeding density at the territory scale and laying date were the variables most influential on nest predation. No single or combined predictors of nest predation were identified among the variables describing nesting buildings and nest placement within them. The dereliction status of buildings and the bulky and accessible nature of chough nests may result in a lack of a general pattern of nest placement that explains nest predation by the entire predator guild. Specific features of nest microhabitat explaining predation rates by particular predator species would require further research associating specific predators with the nests on which they prey, after controlling for the influence of incidental predation.
Geochronology of Neoarchaean granitoids of the NW eastern Dharwar craton: implications for crust formation
Creators: name: Sukanta Dey
name: Halla, Jaana
name: Kurhila, Matti
name: Jinia Nandy
name: Heilimo, Esa
name: Sayantan Pal
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Analytical techniques
In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis
Creators: name: Borrelli, Costanza
name: Roberts, Morgan
name: Eletto, Davide
name: Lafzi, Atefeh
name: Kretz, Jonas A.
name: Fazilaty, Hassan
name: Hussherr, Marie-Didiée
name: Guido Vinzoni, Elena
name: Handler, Kristina
name: Michler, Jan
name: Adivarahan, Srivathsan
name: Piscuoglio, Salvatore
name: Ficht, Xenia Maria
name: Moor, Andreas
Publisher: name: ETH Zurich
Year: 2023

description: It is estimated that only 0.02% of disseminated tumor cells are able to seed overt metastases1. While this indicates the presence of environmental constraints to metastatic seeding, the landscape of host factors controlling this process remains largely unknown. Combining transposon technology2 and fluorescent niche labeling3, we developed an in vivo CRISPR activation screen to systematically investigate the influence of hepatocytes on metastatic seeding in the liver. Our approach enabled the identification of Plexin B2 as a critical host-derived regulator of metastasis. Plexin B2 upregulation in hepatocytes dramatically enhances grafting in colorectal and pancreatic cancer syngeneic models, and promotes seeding and survival of patient-derived organoids. Notably, ablation of Plexin B2 in hepatocytes prevents mesenchymal-to-epithelial transition of extravasated tumor cells and thereby almost entirely suppresses liver metastasis. We dissect a mechanism by which Plexin B2 interacts with class 4 semaphorins on tumor cells, activating Rac1 signaling and actin cytoskeleton remodeling, thereby promoting the acquisition of epithelial traits. Our findings highlight the essential role of signals from the liver parenchyma for the survival of disseminated tumor cells, prior to the establishment of a growth promoting niche. They further suggest that acquisition of epithelial traits is required for the adaptation of extravasated cells to their new tissue environment. Targeting of Plexin B2 on hepatocytes shields the liver from colonizing cells and thus presents an innovative therapeutic strategy for preventing metastasis. Finally, our screening technology, which evaluates host-derived extrinsic signals rather than tumor-intrinsic factors for their ability to promote metastatic seeding, is broadly applicable and lays a framework for the screening of environmental constraints on metastasis in other organs and cancer types.
description: bioRxiv
title: 03_0131
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia
Creators: name: Ivanova, Svetlana A.
name: Osmanova, Diana Z.
name: Freidin, Maxim B.
name: Fedorenko, Olga Yu
name: Boiko, Anastasia S.
name: Pozhidaev, Ivan V.
name: Semke, Arkadiy V.
name: Bokhan, Nikolay A.
name: Agarkov, Alexey A.
name: Wilffert, Bob
name: Loonen, Anton J.M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Objectives: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT). Methods: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs. Results: None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL. Conclusions: This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
In vivo single-cell CRISPR uncovers distinct TNF-α programs in clonal expansion and tumorigenesis
Creators: name: Renz, Peter F.
name: Ghoshdastider, Umesh
name: Baghai Sain, Simona
name: Valdivia-Francia, Fabiola
name: Khandekar, Ameya
name: Ormiston, Mark
name: Bernasconi, Martino
name: Kretz, Jonas A.
name: Lee, Minkyoung
name: Hyams, Katie
name: Forny, Merima
name: Pohly, Marcel
name: Ficht, Xenia Maria
name: Ellis, Stephanie J.
name: Moor, Andreas
name: Sendoel, Ataman
Publisher: name: ETH Zurich
Year: 2023

description: The tumor evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions occur frequently in human epithelia and can remodel almost entire tissues, the mechanisms behind why only a small number of clones transform into malignant tumors remain enigmatic. Here, we develop an in vivo single-cell CRISPR strategy to systematically investigate tissue-wide clonal dynamics of the 150 most frequently mutated squamous cell carcinoma genes. We couple ultrasound-guided in utero lentiviral microinjections, single-cell RNA sequencing, guide capture and spatial transcriptomics to longitudinally monitor cell type-specific clonal expansions, document their underlying gene programs and contrast clonal expansions from tumor initiation. We uncover a TNF-α signaling module that acts as a generalizable driver of clonal expansions in epithelial tissues. Conversely, during tumorigenesis, the TNF-α signaling module is downregulated, and instead, we identify a subpopulation of invasive cancer cells that switch to an autocrine TNF-α gene program. By analyzing clonally expanded perturbations and their frequency in tumors, we demonstrate that the autocrine TNF-α gene program is associated with epithelial-mesenchymal transition (EMT) and is preexistent in a subpopulation of expanded epidermal stem cells, contributing to the predisposition for tumor initiation. Finally, we provide in vivo evidence that the epithelial TNF-α gene program is sufficient to mediate invasive properties of epidermal stem cells and show that the TNF-α signature correlates with shorter overall survival in human squamous cell carcinoma patients. Collectively, our study demonstrates the power of applying in vivo single-cell CRISPR screening to mammalian tissues and unveils distinct TNF-α programs in tumor evolution. Understanding the biology of clonal expansions in phenotypically normal epithelia and the mechanisms governing their transformation will guide the development of novel strategies for early cancer detection and therapy.
description: bioRxiv
Supplementary Material for: Medical Neighborhood Model for the Care of Chronic Kidney Disease Patients
Creators: name: Smith, Z.G.
name: McNicoll, L.
name: Clark, T.L.
name: Cohen, A.J.
name: Ross, A.L.
name: Monteiro J.F.G.
name: Dworkin, L.D.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: The patient-centered medical home is a popular model of care, but the patient-centered medical neighborhood (PCMN) is rarely described. We developed a PCMN in an academic practice to improve care for patients with chronic kidney disease (CKD). The purpose of this study is to identify the prevalence of CKD in this practice and describe baseline characteristics, develop an interdisciplinary team-based approach to care and determine cost associated with CKD patients. Methods: Patients with CKD stage 3a with comorbidities through stage 5 were identified. Data collected include demographics, comorbidities and whether patients had a nephrologist. Using a screening tool based on the 2012 Kidney Disease Improving Global Outcomes guidelines, a nurse care manager (NCM) made recommendations about management including indications for referral. A pharmacist reviewed patients' charts and made medication-related recommendations. Blue Cross Blue Shield (BCBS) insurance provided cost data for a subset of patients. Results: A total of 1,255 patients were identified. Half did not have a formal diagnosis of CKD and three-quarters had never seen a nephrologist. Based on the results of the screening tool, the NCM recommended nephrology E-consult or full consult for 85 patients. The subset of BCBS patients had a mean healthcare cost of $1,528.69 per member per month. Conclusions: We implemented a PCMN that allowed for easy identification of a high-risk, high-cost population of CKD patients and optimized their care to reflect guideline-based standards.
The Developmental Transcription Factor TBX3 Physically Engages with the Wnt/β-catenin Transcriptional Complex in Human Colorectal Cancer Cells to Regulate Metastasis Genes
Creators: name: Jauregi-Miguel, Amaia
name: Söderholm, Simon
name: Weiss, Tamina
name: Nordin, Anna
name: Ghezzi, Valeria
name: Brütsch, Salome M.
name: Pagella, Pierfrancesco
name: van de Grift, Yorick
name: Zambanini, Gianluca
name: Ulisse, Jacopo
name: Mattia, Alessandro
name: Deviatiiarov, Ruslan
name: Faustini, Elena
name: Moparthi, Lavanya
name: Lottersberger, Francisca
name: Koch, Stefan
name: Moor, Andreas
name: Sun, Xiao-Feng
name: von Castelmur, Eleonore
name: Sheng, Guojun
name: Cantù, Claudio
Publisher: name: ETH Zurich
Year: 2023

description: Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear β-catenin. Furthermore, neoplasia of the colorectal epithelium begins with aberrant Wnt/β-catenin signaling. Yet, little is known about how β-catenin generates context-specific transcriptional outcomes. We have previously identified the developmental transcription factor TBX3 as a tissue-specific component of the Wnt/β-catenin nuclear complex during mouse forelimb development. In this study, we show that TBX3 is present and functionally active in human colorectal cancers. TBX3’s genomic binding pattern suggests a regulatory role that broadly coincides with that of Wnt/β-catenin. Moreover, proteomics proximity labelling indicated that, during Wnt pathway activation, TBX3 is vicinal to several protein partners, including the transcription factors TCF/LEF and chromatin remodeling complexes which are usually found at Wnt responsive elements. Sequence and structure analysis revealed that TBX3 possesses an exposed Asp-Pro-Phe (NPF) motif predicted by AlphaFold2 Multimer to mediate direct interactions with several Wnt-activated TBX3 partners. Deletion of NPF abrogates TBX3 proximity to these partners and its ability to modulate Wnt-dependent transcription. TBX3 emerges as a key modulator of the oncogenic activity of Wnt/β-catenin in colorectal cancer, and its mechanism of action exposes a novel druggable protein-interaction surface.
description: bioRxiv
Morphodynamics of human early brain organoid development
Creators: name: Jain, Akanksha
name: Gut, Gilles
name: Sanchís-Calleja, Fátima
name: Okamoto, Ryoko
name: Streib, Simon
name: He, Zhisong
name: Zenk, Fides Lea
name: Santel, Malgorzata
name: Seimiya, Makiko
name: Holtackers, René
name: Jansen, Sophie Martina Johanna
name: Camp, J. Gray
name: Treutlein, Barbara
Publisher: name: ETH Zurich
Year: 2023

description: Brain organoids enable the mechanistic study of human brain development, and provide opportunities to explore self-organization in unconstrained developmental systems. Here, we establish long-term, live light sheet microscopy on unguided brain organoids generated from fluorescently labeled human induced pluripotent stem cells, which enables tracking of tissue morphology, cell behaviors, and subcellular features over weeks of organoid development. We provide a novel dual-channel, multi-mosaic and multi-protein labeling strategy combined with a computational demultiplexing approach to enable simultaneous quantification of distinct subcellular features during organoid development. We track Actin, Tubulin, plasma membrane, nucleus, and nuclear envelope dynamics, and quantify cell morphometric and alignment changes during tissue state transitions including neuroepithelial induction, maturation, lumenization, and brain regionalization. Based on imaging and single-cell transcriptome modalities, we find that lumenal expansion and cell morphotype composition within the developing neuroepithelium are associated with modulation of gene expression programs involving extracellular matrix (ECM) pathway regulators and mechanosensing. We show that an extrinsically provided matrix enhances lumen expansion as well as telencephalon formation, and unguided organoids grown in the absence of an extrinsic matrix have altered morphologies with increased neural crest and caudalized tissue identity. Matrixinduced regional guidance and lumen morphogenesis are linked to the WNT and Hippo (YAP1) signaling pathways, including spatially restricted induction of the Wnt Ligand Secretion Mediator (WLS) that marks the earliest emergence of nontelencephalic brain regions. Altogether, our work provides a new inroad into studying human brain morphodynamics, and supports a view that matrix-linked mechanosensing dynamics play a central role during brain regionalization.
description: bioRxiv
Country-Scale Cropland Mapping in Data-Scarce Settings Using Deep Learning: A Case Study of Nigeria
Creators: name: Gajardo, Joaquin
name: Volpi, Michele
name: Onwude, Daniel
name: Defraeye, Thijs
Publisher: name: ETH Zurich
Year: 2023
Subjects: Computer Vision and Pattern Recognition (cs.CV)
FOS: Computer and information sciences
Deep Learning
Agriculture
Satellite images
Time series
Transfer learning
Large-scale mapping
Sentinel

description: Cropland maps are a core and critical component of remote-sensing-based agricultural monitoring, providing dense and up-to-date information about agricultural development. Machine learning is an effective tool for large-scale agricultural mapping, but relies on geo-referenced ground-truth data for model training and testing, which can be scarce or time-consuming to obtain. In this study, we explore the usefulness of combining a global cropland dataset and a hand-labeled dataset to train machine learning models for generating a new cropland map for Nigeria in 2020 at 10 m resolution. We provide the models with pixel-wise time series input data from remote sensing sources such as Sentinel-1 and 2, ERA5 climate data, and DEM data, in addition to binary labels indicating cropland presence. We manually labeled 1827 evenly distributed pixels across Nigeria, splitting them into 50\% training, 25\% validation, and 25\% test sets used to fit the models and test our output map. We evaluate and compare the performance of single- and multi-headed Long Short-Term Memory (LSTM) neural network classifiers, a Random Forest classifier, and three existing 10 m resolution global land cover maps (Google's Dynamic World, ESRI's Land Cover, and ESA's WorldCover) on our proposed test set. Given the regional variations in cropland appearance, we additionally experimented with excluding or sub-setting the global crowd-sourced Geowiki cropland dataset, to empirically assess the trade-off between data quantity and data quality in terms of the similarity to the target data distribution of Nigeria. We find that the existing WorldCover map performs the best with an F1-score of 0.825 and accuracy of 0.870 on the test set, followed by a single-headed LSTM model trained with our hand-labeled training samples and the Geowiki data points in Nigeria, with a F1-score of 0.814 and accuracy of 0.842.
description: arXiv
Limpsfield Medieval Coarseware: a Descriptive Analysis
Creators: name: Prendergast, Martin D
Publisher: name: Archaeology Data Service
Year: 2008

description: Surrey Archaeological Collections, 70, 57-77
description: TQ 423526 etc. Past work is summarised and a fresh approach based on zone-groups adopted. Statistical discussion of the wares leads to the conclusion that the various sites produced fairly uniform styles over 150 years. Further work should concentrate on texture, rim forms, handles and decoration, with analyses of source clays and fired clays. Figures show 100 pots.
MOVES V. Modelling star-planet magnetic interactions of HD 189733
Creators: name: Strugarek, A.
name: Fares, R.
name: Bourrier, V.
name: Brun, A. S.
name: Réville, V.
name: Amari, T.
name: Helling, Ch.
name: Jardine, M.
name: Llama, J.
name: Moutou, C.
name: Vidotto, A. A.
name: Wheatley, P. J.
name: Zarka, P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Magnetic interactions between stars and close-in planets may lead to a detectable signal on the stellar disk. HD 189733 is one of the key exosystems thought to harbor magnetic interactions, which may have been detected in August 2013. We present a set of twelve wind models at that period, covering the possible coronal states and coronal topologies of HD 189733 at that time. We assess the power available for the magnetic interaction and predict its temporal modulation. By comparing the predicted signal with the observed signal, we find that some models could be compatible with an interpretation based on star-planet magnetic interactions. We also find that the observed signal can be explained only with a stretch-and-break interaction mechanism, while that the Alfvén wings scenario cannot deliver enough power. We finally demonstrate that the past observational cadence of HD 189733 leads to a detection rate of only between 12 to 23%, which could explain why star-planet interactions have been hard to detect in past campaigns. We conclude that the firm confirmation of their detection will require dedicated spectroscopic observations covering densely the orbital and rotation period, combined with scarcer spectropolarimetric observations to assess the concomitant large-scale magnetic topology of the star.
description: 16 pages, 8 figures, 4 tables, accepted for publication in MNRAS
Greedy Heuristics and Linear Relaxations for the Random Hitting Set Problem
Creators: name: Arpino, Gabriel
name: Dmitriev, Daniil
name: Grometto, Nicolo
Publisher: name: ETH Zurich
Year: 2023
Subjects: Probability (math.PR)
Discrete Mathematics (cs.DM)
Data Structures and Algorithms (cs.DS)
Optimization and Control (math.OC)
FOS: Mathematics
FOS: Computer and information sciences

description: Consider the Hitting Set problem where, for a given universe $\mathcal{X} = \left\{ 1, ... , n \right\}$ and a collection of subsets $\mathcal{S}_1, ... , \mathcal{S}_m$, one seeks to identify the smallest subset of $\mathcal{X}$ which has nonempty intersection with every element in the collection. We study a probabilistic formulation of this problem, where the underlying subsets are formed by including each element of the universe with probability $p$, independently of one another. For large enough values of $n$, we rigorously analyse the average case performance of Lovász's celebrated greedy algorithm (Lovász, 1975) with respect to the chosen input distribution. In addition, we study integrality gaps between linear programming and integer programming solutions of the problem.
description: arXiv
Betriebliche Abwärme zur Aufbereitung von Sekundärrohstoffen (Technology Talk)
Creators: name: Secklehner, Jürgen
Publisher: name: NEFI
Year: 2025
Subjects: NEFI
Innovationsnetzwerk
Energie
Industrie
New Energy for Industry
Klima- und Energiefonds
Vorzeigeregion
Technology Talk
Abwärme
Abwärmenutzung

description: Der NEFI Technology Talk „Betriebliche Abwärmenutzung“ des OÖ Energiesparverbandes zeigte Möglichkeiten der innerbetrieblichen Abwärmenutzung auf, und zwar für Produktionsprozesse, zur Raumheizung und -kühlung oder zur Warmwasseraufbereitung.

Die NEFI Technology Talks sind eine Veranstaltungsreihe, die sich aktuellen technischen und systemischen Fragestellungen rund um die industrielle Energiewende der Industrie widmen.

Der Talk wurde im Rahmen des NEFI Projektes TCP_to_Industry durchgeführt. Mehr zu diesem Projekt finden Sie hier.
Rediscovery of One of the Rarest Species of Tanyderidae: An Anecdotal Field Account.pdf
Creators: name: Madriz, Ruben
Publisher: name: figshare
Year: 2016
Subjects: subject: 60899 Zoology not elsewhere classified
subject: FOS: Biological sciences

description: 1. Rediscovery of Neoderus
Identifying Spatial Co-occurrence in Healthy and InflAmed tissues (ISCHIA)
Creators: name: Lafzi, Atefeh
name: Borrelli, Costanza
name: Bach, Karsten
name: Kretz, Jonas A.
name: Handler, Kristina
name: Regan-Komito, Daniel
name: Ficht, Xenia Maria
name: Frei, Andreas
name: Moor, Andreas
Publisher: name: ETH Zurich
Year: 2023

description: Spatial transcriptomics techniques are able to chart the distribution and localization of cell types and RNA molecules across a tissue. Here, we generated matched sequencing-based (Visium) and hybridization-based (Molecular Cartography) spatial transcriptomics data of human IBD samples. We then developed ISCHIA (Identifying Spatial Co-occurrence in Healthy and InflAmed tissues), a computational framework to analyze the spatial co-occurrence of cell types and transcript species in the tissue environment. ISCHIA revealed tightly associated cellular networks, ligand-receptor interactions enriched in the inflamed human colon, and their associated gene signatures, highlighting the hypothesis-generating power of co-occurrence analysis on spatial transcriptomics data.
description: bioRxiv
A generic framework of adiabatic approximation for nonlinear evolutions II
Creators: name: Zhang, Jingxuan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 37L05, 37L25

description: In this paper, we continue the development of a generic adiabatic scheme for nonlinear evolutions. We consider an abstract gradient flow of some energy functional, together with a given manifold of static solutions arising from broken symmetries. First, we list a number of explicit and generic conditions on the energy functional that ensures the validity of our adiabatic scheme. Then, we construct some explicit low-energy but no necessarily static configurations, which form a stable manifold with finite codimensions for the given gradient flow. Thirdly, we show that the gradient flow is globally well-posed with initial configuration from the stable manifold. Finally, we show that any solution to the full gradient flow starting from the stable manifold is essentially governed by an effective equation on the manifold of static solutions, up to a uniformly small and dissipating error term.
description: 27pp. Part I has appeared in arxiv.org:2103.05932
Fast analysis of volatile compounds from Lippia citriodora with nanoporous aluminum wire as solid-phase microextraction fibres
Creators: name: Kharajuo, Mohammad Nemati
name: Piryaei, Marzieh
name: Asl, Marzieh Babashpour
name: Abolghasemi, Mir Mahdi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: In this study, the efficiency of nanoporous aluminium wires as fibres for headspace solid-phase microextraction (HS-SPME) of volatile compounds from Lippia citriodora was investigated and compared with two anodised methods. The prepared fibres are durable with very good chemical and thermal stability which can be coupled to GC and GC/MS. A one at-a-time optimisation strategy was applied for optimising the important extraction parameters such as extraction temperature, extraction time, sample mass and added water. Compared with hydrodistillation (HD), HS-SPME provide the advantages of a small amount of sample, time-saving, simplicity and cheapness.
Burials on the Hog's Back excavated in 1935
Creators: name: English, Judie
name: Dyer, Steve
Publisher: name: Archaeology Data Service
Year: 2002

description: Surrey Archaeological Collections, 86, 215-216
description: Publishes what is known of a small group of burials encountered during utility works beside the A31 highway. Thought by the excavator to be Neolithic, doubts were raised and it was subsequently suggested that the bodies were of seventeenth-century plague victims.
A comprehensive study of decay modes associated with Pb isotopes
Creators: name: Sharma, R.
name: Jain, A.
name: Sharma, P. K.
name: Jain, S. K.
name: Saxena, G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Decay modes in Pb isotopes within the range 176$\leq$A$\leq$266 are investigated by the calculation of half-lives using several empirical formulas. These formulas along with various theoretical treatments are first tested to reproduce experimental half-lives and known decay modes of Pb isotopes, which are in consequence applied to estimate half-lives and decay modes of unknown Pb isotopes. A comparison between $α$-decay and weak-decay from the stable to drip-line isotopes is canvassed which leads to the excellent match with experimental data and applicability of applied empirical formulas. In addition, the full chain of Pb isotopes is probed as potential daughter candidates of cluster emission from superheavy nuclei which ensued the predominant role of $^{208}$Pb and nearby isotopes in probable cluster emission.
description: 12 pages, 2 figures, Accepted in Physica scripta, 2022
Unitary Complexity and the Uhlmann Transformation Problem
Creators: name: Bostanci, John
name: Efron, Yuval
name: Metger, Tony
name: Poremba, Alexander
name: Qian, Luowen
name: Yuen, Henry
Publisher: name: ETH Zurich
Year: 2023
Subjects: Quantum Physics (quant-ph)
Computational Complexity (cs.CC)
Cryptography and Security (cs.CR)
FOS: Physical sciences
FOS: Computer and information sciences

description: State transformation problems such as compressing quantum information or breaking quantum commitments are fundamental quantum tasks. However, their computational difficulty cannot easily be characterized using traditional complexity theory, which focuses on tasks with classical inputs and outputs. To study the complexity of such state transformation tasks, we introduce a framework for unitary synthesis problems, including notions of reductions and unitary complexity classes. We use this framework to study the complexity of transforming one entangled state into another via local operations. We formalize this as the Uhlmann Transformation Problem, an algorithmic version of Uhlmann's theorem. Then, we prove structural results relating the complexity of the Uhlmann Transformation Problem, polynomial space quantum computation, and zero knowledge protocols. The Uhlmann Transformation Problem allows us to characterize the complexity of a variety of tasks in quantum information processing, including decoding noisy quantum channels, breaking falsifiable quantum cryptographic assumptions, implementing optimal prover strategies in quantum interactive proofs, and decoding the Hawking radiation of black holes. Our framework for unitary complexity thus provides new avenues for studying the computational complexity of many natural quantum information processing tasks.
description: arXiv
Synthesis and fungicidal activity of tryptophan analogues – the unexpected calycanthaceous alkaloid derivatives
Creators: name: Shaojun Zheng
name: Yongdong Gu
name: Longbo Li
name: Zhu, Rui
name: Xingwei Cai
name: Hongjin Bai
name: Jiwen Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology

description: A series of 21 N-protected tryptophan derivatives were synthesised from tryptophan in good yields. Their structures were characterised by IR, 1H NMR, 13C NMR, DEPT (90° and 135°) and MS analysis. The synthesised compounds were evaluated against a wide variety of plant pathogen fungi. Compounds a19 and a21 displayed activity against Fusarium oxysporum (F. oxysporum), and compound a21 showed high activity against F. oxysporum and Eggplant Verticillium, with EC50 values of 58.27 and 77.39 μg mL−1, respectively. Considering that the bioassay of the title compounds was evaluated, effects of the chain alkyl substituents may contribute to the significant variations in fungicidal potency. Their structure–antifungal activity relationships were also discussed. These results will pave the way for further design, structural modification and development of calycanthaceous alkaloids as antimicrobial agents.