cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gamma-ray bursts from accreting black holes in neutron star mergers
Creators: name: Ruffert, M.
name: Janka, H. -Th.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: By means of three-dimensional hydrodynamic simulations with a Eulerian PPM code we investigate the formation and the properties of the accretion torus around the stellar mass black hole which originates from the merging of two neutron stars. The simulations are performed with four nested cartesian grids which allow for both a good resolution near the central black hole and a large computational volume. They include the use of a physical equation of state as well as the neutrino emission from the hot matter of the torus. The gravity of the black hole is described with a Newtonian and alternatively with a Paczynski-Wiita potential. In a post-processing step, we evaluate our models for the energy deposition by nu-nubar annihilation around the accretion torus. Our models show that nu-nubar annihilation can yield the energy to account for weak, short gamma-ray bursts, if moderate beaming is involved. In fact, the barrier of the dense baryonic gas of the torus suggests that the low-density pair-photon-plasma is beamed as axial jets into a fraction 2 delta Omega/ (4 pi) between 1/100 and 1/10 of the sky, corresponding to opening half-angles of roughly ten to several tens of degrees. Thus gamma-burst energies of 10^{50}--10^{51} erg seem within the reach of our models (if the source is interpreted as radiating isotropically), corresponding to luminosities around 10^{51} erg/s for typical burst durations of 0.1--1 s. Gravitational capture of radiation by the black hole, redshift and ray bending do not reduce the jet energy significantly. Effects associated with the Kerr character of the rapidly rotating black hole, however, could increase the gamma-burst energy considerably, and effects due to magnetic fields might even be required to get the energies for long complex gamma-ray bursts.
description: 34 pages, 34 figures, submitted to A&A
Flattened non-Gaussianities from the effective field theory of inflation with imaginary speed of sound
Creators: name: Garcia-Saenz, Sebastian
name: Renaux-Petel, Sébastien
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Inflationary perturbations in multi-field theories can exhibit a transient tachyonic instability as a consequence of their non-trivial motion in the internal field space. When an effective single-field description is applicable, the resulting theory is characterized by fluctuations that propagate with an $imaginary$ speed of sound. We use the effective field theory of fluctuations to study such a set-up in a model-independent manner, highlighting the peculiarities and subtleties that make it different from the standard case. In particular, perturbations feature exponentially growing and decaying modes whose relative amplitude is undetermined within the effective field theory. Nevertheless, we prove that in an interesting limit the dimensionless bispectrum is in fact universal, depending only on the speed of sound and on the cutoff scale that limits the validity of the effective theory. Contrary to the power spectrum, we find that the bispectrum does not display an exponential enhancement. The amplitude of non-Gaussianities in the equilateral configuration is similar to the one of conventional models, but it is enhanced in flattened configurations in a way that is ultraviolet sensitive.
description: 28 pages; v2: appendix added, matches version published in JCAP
title: Rapport de voyage, De Grasse (1924) : Ligne des Antilles, 1953, voyage n°1
Creators: name: Choplin, Guy
name: De Saint-Sauveur, Charles
name: Lejeune, Jacques
name: Monnier, Albert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Compagnie Générale Transatlantique
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapports d'inspecteurs - Rapport général / du capitaine - Rapport du commissaire - Rapport du second - Rapport de l'officier de sécurité - Rapport de l'officier de navigation - Rapport du médecin - Rapport contentieux
description: Source: French Lines & Compagnies, 1997 004 4980-19
description: Coverage: 1953-01-10/1953-02-14
Creep age forming investigation on aluminum alloy 2219 and related studies
Creators: name: Yang, Haoliang
Publisher: name: Imperial College London
Year: 2013

description: By the middle of the 20th Century, traditional mechanical metal forming methods were showing to be inadequate for producing components comprising of large high strength aluminium alloy panels with complex curvatures, such as those used in modern aircraft and aerospace metal structures. To deal with this problem, a new forming method was conceived by Textron, which has proven to be very useful for forming components with these shape characteristics and good mechanical properties. The method is called Creep Age Forming (CAF). The research described in this thesis is a study of CAF of a 2219 aluminium alloy, which is used for fabricating the isogrid structure for fuel tanks of launch vehicles. The main aim of the research is to develop experimental and modelling tools for CAF of AA2219 sheet structures. A series of creep-ageing tests and stress-relaxation tests have been conducted on AA2219 at 175 °C . The age-hardening, creep deformation and stress relaxation behaviour of AA2219 have been investigated. Based on the experimental investigation, a novel set of physically based, unified creep constitutive equations has been established. A small scale CAF test rig was designed to validate the springback prediction from FE simulation. The experimental result and simulation are in good agreement. Development of FE procedures for simulating creep-ageing behaviour of the material and springback has been performed to predict and assess the springback behaviour of metal sheet in typical forming tools.
Picus pileatus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Piciformes
Picidae
Picus
Picus pileatus

description: Picus pileatus [spec. nov.]
P. niger, capite cristato rubro, temporibus alisque albis maculis.
Picus niger maximus, capite rubro. Catesb. car. 2. p. 17. t. 17. Kalm. itin. 2. p. 271.
Ipecu. Marcgr. bras. 207.
Habitat in America.
Differt a P. cornicino, quod tempora alba; maculae aliquot parvae in alis albae; caput magis late coccineum.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 113, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
title: Predicting Attitude Toward Sex Education in Public Schools
Creators: name: Gibson, Sarah A.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2008

description: According to the National Center for Health Statistics, the teen pregnancy rate rose by 3% between 2005 and 2006, presenting the first increase since 1991. These findings are troubling in light of the consequences of teen pregnancy to teen mothers, their children, and society in general. Many commentators suggest that one method of reducing the rate of teen pregnancies is through sex education programs, particularly in the public school system. However, despite the fact that discussions of sex education in public school have been present since the 1920s, polls indicate that there is still a portion of the public that is unsupportive of these programs. The present study seeks to fill a gap in the literature by investigating predictors of support for sex education in public schools using data from the 2006 General Social Survey. It has been over 25 years since this topic has been examined in the social science literature. Guided by the seminal work of sexuality theorist Ira L. Reiss, I examine the impact of labor shortages, religiosity, militarism, gender egalitarianism, regulation of sexuality, and a naturalistic view of sexuality on attitudes toward sex education. Results suggest that a number of Reiss's theoretical concepts are predictive of attitude toward sex education in public schools. Hispanics, those with high levels of religiosity, those who perceived that it would be difficult to find a job, and those who supported regulation of sexuality were shown to be significantly less likely to support sex education in public schools. When compared to previous research, the findings from this study show that predictors of attitude toward sex education have changed over the last 25 years. Finally, due to the overwhelming support for sex education observed in this study, future research should examine predictors of attitude toward the content of sex education programs instead of general support or opposition.
4−Remainder Cordial Labeling of Some Graphs
Creators: name: R. Ponraj
name: K. Annathurai
Publisher: name: figshare
Year: 2018
Subjects: Algebra

description: In this paper we investigate the 4- remainder cordial behavior of grid, subdivision of crown, Subdivision of bistar, book, Jelly fish, subdivision of Jelly fish, Mongolian tent graphs.
Mass and Mass Scalings of Super-Earths
Creators: name: Wu, Yanqin
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The majority of the transiting planets discovered by the Kepler mission (called super-Earths here, includes the so-called 'sub-Neptunes') orbit close to their stars. As such, photoevaporation of their hydrogen envelopes etch sharp features in an otherwise bland space spanned by planet radius and orbital period. This, in turn, can be exploited to reveal the mass of these planets, in addition to techniques such as radial velocity and transit-timing-variation. Here, using updated radii for Kepler planet hosts from Gaia DR2, I show that the photoevaporation features shift systematically to larger radius for planets around more massive stars (ranging from M-dwarfs to F-dwarfs), corresponding to a nearly linear scaling between planet mass and its host mass. By modelling planet evolution under photo-evaporation, one further deduces that the masses of super-Earths peak narrowly around $8 M_\oplus (M_*/M_\odot)$. Moreover, the composition of their cores is likely terrestrial, and they were initially coated with H/He envelopes a couple percent in mass. Interestingly, the masses of these planets do not appear to depend on the metallicity values of their host stars, while they may depend on the orbital separation weakly, possibly as $r^{1/2}$. Taken together, the simplest interpretation of our results is that super-Earths are at the so-called 'thermal mass', where the planet's Hill radius is equal to the vertical scale height of the gas disk.
description: expanded discussions on statistics and thermal mass in active disks; accepted to ApJ
Additional file 1 of Consequences of ignoring clustering in linear regression
Creators: name: Ntani, Georgia
name: Inskip, Hazel
name: Osmond, Clive
name: Coggon, David
Publisher: name: figshare
Year: 2021
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1: Appendix A. Data generating algorithm for clustered data with continuous outcome and explanatory variables. Appendix B. Data generating algorithm for clustered data with continuous outcome and binary explanatory variables. Supplementary Table 1. Standard deviation of derived $${\beta }_{1}^{RI}$$ β 1 RI and $${\beta }_{1}^{OLS}$$ β 1 OLS when $${x}_{ij}$$ x ij was continuous according to fifths of the distribution of dispersion (expressed as SD) of the continuous $${\stackrel{-}{x}}_{j}$$ x - j . Supplementary Table 2. Standard deviation of derived $${\beta }_{1}^{RI}$$ β 1 RI and $${\beta }_{1}^{OLS}$$ β 1 OLS when $${x}_{ij}$$ x ij was binary according to fifths of the distribution of dispersion (expressed as SD) of the prevalence of $${x}_{j}$$ x j across clusters, and overall target prevalence of $${x}_{ij}$$ x ij . Supplementary Table 3. Percentage (%) of datasets for which the null hypothesis was rejected according to level of ICC when $${\beta }_{1}=0$$ β 1 = 0 and $${x}_{ij}$$ x ij was continuous according to fifths of the distribution of dispersion (expressed as SD) of the continuous $${\stackrel{-}{x}}_{j}$$ x - j . Supplementary Table 4. Interval coverage rates by ICC levels when clustering in the continuous explanatory variable was minimal (dispersion of the continuous $${\stackrel{-}{x}}_{j}$$ x - j <0.2 SDs).
Curvature Invariants for Lorentzian Traversable Wormholes
Creators: name: Mattingly, B.
name: Kar, A.
name: Julius, W.
name: Gorban, M.
name: Watson, C.
name: Ali, M. D.
name: Baas, A.
name: Elmore, C.
name: Shakerin, B.
name: Davis, E. W.
name: Cleaver, G. B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A process for using curvature invariants is applied as a new means to evaluate the traversability of Lorentzian wormholes and to display the wormhole spacetime manifold. This approach was formulated by Henry, Overduin and Wilcomb for Black Holes in Reference [1]. Curvature invariants are independent of coordinate basis, so the process is free of coordinate mapping distortions and the same regardless of your chosen coordinates. The four independent Carminati and McLenaghan (CM) invariants are calculated and the non-zero curvature invariant functions are plotted. Three example traversable wormhole metrics (i) spherically symmetric Morris and Thorne, (ii) thin-shell Schwarzschild wormholes, and (iii) the exponential metric are investigated and are demonstrated to be traversable.
description: 16 pages, 9 figures
Lettre de Karl Frederik Ferber à Jean-François Séguier, 1773-09-05
Creators: name: Ferber, Karl Frederik
name: Ferber, Karl Frederik
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Botanique

description: [transcription] A Montpellier ce 5e septembre 1773.

Monsieur,

A mon passage à Nîmes jeudi dernier je fus chez vous pour avoir l'honneur de vous voir, mais on me dit que vous étiez à Agde depuis quelque temps. Je jugeais de là que vous n'aviez peut-être pas reçu la lettre que j'eus l'honneur de vous écrire le 18 août de Marseille pour vous faire part qu'il y avait une occasion pour la Suède, ce qui s'est trouvé vérifié par la lecture de l'agréable vôtre du 22 du même mois, que j'ai trouvé devant moi ici. Pour y satisfaire, il sera très bien que vous ayez la bonté de faire passer à votre retour à Nîmes vers le 20 ou la fin de ce mois le paquet de plantes destiné à mon frère, à Marseille, pour profiter de la susdite occasion. Comme j'y ai mon frère cadet, je vous prie de lui adresser ce paquet en lui marquant en deux mots que c'est pour envoyer en Suède. J'aurais soin de l'instruire du reste et d'en procurer l'envoi. Son adresse est Gustave Ferber, chez Messieurs Grenier frères et Cie à Marseille. [Le paquet a été envoyé le 28e de Nîmes à Marseille par la messagerie] [fol. 28 v] Je compte me rendre dans 15 jours à Sète pour y passer l'hiver. Je suis toujours à vos ordres, lorsque vous voudrez bien disposer de moi puisque je serai charmé de trouver des occasions à vous procurer l'estime distinguée avec laquelle j'ai l'honneur d'être constaamment.

Monsieur,

Votre très humble et très obéissant serviteur,

Charles Fred. Ferber
description: [note autre main] [Le paquet a été envoyé le 28e de Nîmes à Marseille par la messagerie]
description: [personnes citées] Frères Grenier, Gustav Ferber
description: Source: [lieu de Conservation] Nîmes, Bibliothèque Carré d'Art [cote]ms. 94_1, fol. 28-29
description: Source: ark:/12148/btv1b100150711
The role of gut hormones in energy homeostasis
Creators: name: McCullough, Katherine Anne
Publisher: name: Imperial College London
Year: 2013

description: Obesity is an increasing worldwide problem and yet current pharmaceutical treatments only produce modest weight loss which is rarely sustained. Glucagon and glucagon-like peptide-1 (GLP-1) are members of the secretin family of peptide hormones. Both hormones are products of the preproglucagon gene, and are produced in the pancreas and gut respectively. GLP-1 is an incretin hormone that enhances glucose-mediated insulin release and inhibits glucagon secretion. In contrast, glucagon counter-regulates insulin and stimulates gluconeogenesis in response to low circulating levels of glucose. Despite their opposing roles in glucose homeostasis, both hormones reduce food intake in rodents and humans. In addition, glucagon increases energy expenditure. In this thesis, I have investigated for the first time the effects of co-administration of glucagon and GLP-1 in energy balance. Co-administration of glucagon and GLP-1 in mice significantly reduced food intake compared to controls and appeared to do so in an additive manner. Glucagon and GLP-1 alone and in combination activated similar areas within the brainstem and amygdala. Prolonged co-administration of novel, protease- resistant analogues of glucagon and GLP-1 reduced body weight in diet-induced obese (DIO) mice, despite similar food intake compared to saline controls. Furthermore, glucagon and GLP- 1 analogue co -administration improved glucose homeostasis compared to saline controls in DIO mice. Intravenous infusion of glucagon alone and in combination with GLP-1 increased energy expenditure in overweight humans whilst GLP-1 alone had no effect. This represents a first in man study of the effects of co-administration of glucagon and GLP-1 on energy homeostasis . Sub-anorectic doses of glucagon and GLP-1 in combination reduced food intake whilst alone they had no effect. Co -administration of both hormones ameliorated the rise in plasma glucose seen following glucagon infusion alone, demonstrating an additional benefit of GLP-1 and glucagon in combination. These findings suggest that the combination of GLP-1 and glucagon represents an exciting therapeutic target for development of a novel anti-obesity agent.
Regulation of microRNAs and analysis of the splicing inhibitor Spliceostatin A
Creators: name: Sarkar, Priti Rupa
Publisher: name: Imperial College London
Year: 2013

description: The advent of deep sequencing has revealed marked differences in microRNA (miRNA) expression profiles between cell types. We focus on how miRNAs are regulated in embryonic stem cells (ESCs) and their differentiated neural progenitor stem cells (NPSCs). We discovered that 60% of miRNAs are regulated b y transcription. The remaining 40% of miRNAs were transcribed but not processed in ESCs. Furthermore, systematic analysis of miRNAs on chromosome 1 and 2 helped to validate our results. We show that 43% of these miRNAs, which are highly expressed in differentiated cell types but poorly expressed in ESCs, were transcribed but not processed in ESCs. Therefore we infer that post- transcr iptional regulation of miRNAs is prevalent in ESCs and could potentially be a characteristic of this cell type. Post-transcriptional regulation of miRNAs is also evident in miRNA clusters. Clusters of miRNAs are transcribed together however individual mature miRNA expression often differs between tissues and even within the same tissue type. Following investigation into post-transcriptional regulation, we discovered extensive alternative polyadenylation in three different miRNA clusters. We suggest that alternative polyadenylation has the potential to influence regulation of individual miRNAs within a cluster contributing to their differential expression levels.
Additional file 1 of Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran
Creators: name: Goshayeshi, Ladan
name: Akbari Rad, Mina
name: Bergquist, Robert
name: Allahyari, Abolghasem
name: Hashemzadeh, Kamila
name: Hoseini, Benyamin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1. STROBE Statement—Checklist of items that should be included in reports of cross-sectional studies.
title: Predictors of Pre-Dispositional Juvenile Detention: Race Gender and Intersectionality
Creators: name: Gebler, Jennifer Lee
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2011

description: This research examines disproportionate minority contact (DMC) in a court service unit (CSU) in Virginia which has been implementing the Juvenile Detention Alternatives Initiative (JDAI) program since 2005. Using three years of intake data, the study also explores the impact of race and gender on the likelihood of receiving pre-dispositional secure detention. Finally, using intersectionality theory, the study analyzes the joint impact of being non-white and female on the pre-dispositional detention outcome. In this CSU, non-whites were found to be overrepresented in secure detention indicating the presence of DMC. In the multivariate model, race was not found to be a significant predictor of pre-dispositional juvenile detention, but gender was significantly related to the detention decision. The interaction of race and gender was not found to significantly predict the detention decision. Germane policy implications are discussed as well as limitations and directions for future research.
On Topological Quantum Computing With Mapping Class Group Representations
Creators: name: Bloomquist, Wade
name: Wang, Zhenghan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Algebra (math.QA)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 57M99, 57R56, 81P68

description: We propose an encoding for topological quantum computation utilizing quantum representations of mapping class groups. Leakage into a non-computational subspace seems to be unavoidable for universality in general. We are interested in the possible gate sets which can emerge in this setting. As a first step, we prove that for abelian anyons, all gates from these mapping class group representations are normalizer gates. Results of Van den Nest then allow us to conclude that for abelian anyons this quantum computing scheme can be simulated efficiently on a classical computer. With an eye toward more general anyon models we additionally show that for Fibonnaci anyons, quantum representations of mapping class groups give rise to gates which are not generalized Clifford gates.
description: 26 pages, 18 figures, Updates to presentation of material. To appear in Journal of Physics A
Additional file 1 of Comparing regression modeling strategies for predicting hometime
Creators: name: Holodinsky, Jessalyn K.
name: Yu, Amy Y. X.
name: Kapral, Moira K.
name: Austin, Peter C.
Publisher: name: figshare
Year: 2021
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Figure S1. Calibration plots displaying actual 90-day hometime plotted against predicted hometime across the test data set using eight different statistical models with 15 clinically relevant covariates. Figure S2. Calibration plots displaying actual 90-day hometime plotted against predicted hometime across the test data set using seven different machine learning models with 15 clinically relevant covariates.
Flavorful Two Higgs Doublet Models with a Twist
Creators: name: Altmannshofer, Wolfgang
name: Maddock, Brian
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore Two Higgs Doublet Models with non-standard flavor structures. In analogy to the four, well studied, models with natural flavor conservation (type 1, type 2, lepton-specific, flipped), we identify four models that preserve an approximate $U(2)^5$ flavor symmetry acting on the first two generations. In all four models, the couplings of the 125 GeV Higgs are modified in characteristic flavor non-universal ways. The heavy neutral and charged Higgs bosons show an interesting non-standard phenomenology. We discuss their production and decay modes and identify the most sensitive search channels at the LHC. We study the effects on low energy flavor violating processes finding relevant constraints from $B_d$ and $B_s$ meson oscillations and from the rare decay $B_s \to μ^+ μ^-$. We also find that lepton flavor violating $B$ meson decays like $B_s \to τμ$ and $B \to K^{(*)} τμ$ might have branching ratios at an observable level.
description: 42 pages, 8 figures, 4 tables
GraphRank Pro+: Advancing Talent Analytics Through Knowledge Graphs and Sentiment-Enhanced Skill Profiling
Creators: name: Velampalli, Sirisha
name: Muniyappa, Chandrashekar
Publisher: name: arXiv
Year: 2025
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: I.2.7
subject: 05C81

description: The extraction of information from semi-structured text, such as resumes, has long been a challenge due to the diverse formatting styles and subjective content organization. Conventional solutions rely on specialized logic tailored for specific use cases. However, we propose a revolutionary approach leveraging structured Graphs, Natural Language Processing (NLP), and Deep Learning. By abstracting intricate logic into Graph structures, we transform raw data into a comprehensive Knowledge Graph. This innovative framework enables precise information extraction and sophisticated querying. We systematically construct dictionaries assigning skill weights, paving the way for nuanced talent analysis. Our system not only benefits job recruiters and curriculum designers but also empowers job seekers with targeted query-based filtering and ranking capabilities.
Dense Molecular Clouds In The Galactic Center Region : I. HCN (J=1$-$0) DATA
Creators: name: Lee, Chang Won
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Galactic Center regions $-6^\circ \le l \le 6^\circ$ and $-0.8^\circ \le b \le 0.87^\circ$ are surveyed with HCN J=1$-$0 line (88.6 GHz) on a 4$'$ grid with the 14 m telescope at the Taeduk Radio Astronomy Observatory. The data complement the previous $^{13}$CO, CS, and H$_2$CO measurements (Bally \etal 1988, Zylka \etal 1992) but cover a wider area with a better or comparable resolution. The asymmetry in emission found in the $^{13}$CO observations by Bally \etal (1988) is well confirmed in this study. Interestingly, the asymmetry in HCN emission is more pronounced here: more than $80 \%$ of the overall emission is found in the first quadrant ($l>0$) and $V_{LSR}>0$. Also confirmed is the existence of several emission components in the regions forbidden by the Galactic circular rotation. The HCN maps show clear absence of both more outer galactic emissions and the 3 kpc arm component, which are both visible in the $^{13}$CO map. This implies that the HCN emission lines are not contaminated by foreground or background gas components. Therefore HCN data are particularly useful in investigating the structures of molecular clouds in the Galactic Center. The $ΔV$s (FWHMs) of the most of the detected lines are found to be very large, \ie, about $15\sim $55 km s$^{-1}$ with the mode at $ΔV \approx25$ km s$^{-1}$. The typical value of $ΔV\approx 25$ km s$^{-1}$ may imply that clouds with mass of an order of $10^6 \msun$ are common in the GC region. Another trend found is that the maximum $ΔV$ decreases with $l$, which may be partly due to the overlapping effects of clouds.
description: ApJS submitted, 14 pages with 22 figures, uuencoded, gzipped, tarred postscript files, or available upon request to cwl@sarang.chungnam.ac.kr
Additional file 1 of Switching from TNFα inhibitor to tacrolimus as maintenance therapy in rheumatoid arthritis after achieving low disease activity with TNFα inhibitors and methotrexate: 24-week result from a non-randomized, prospective, active-controlled trial
Creators: name: Jung, Sang Youn
name: Koh, Jung Hee
name: Kim, Ki-Jo
name: Park, Yong-Wook
name: Yang, Hyung-In
name: Choi, Sung Jae
name: Lee, Jisoo
name: Choi, Chan-Bum
name: Kim, Wan-Uk
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1:. Supplemental Figure 1 and Table 1
Structural characterization of the polycomb repressor complex 1 binding partner ubiquitin specific protease 11
Creators: name: Sharif, Azar
Publisher: name: Imperial College London
Year: 2013

description: Ubiquitin Specific Protease 11 (USP11), USP4 and USP15 are highly conserved and are characterised by an N-terminal “domain present in ubiquitin specific proteases” (DUSP) and “ubiquitin-like” (UBL) domains. This DUSP-UBL (DU) domain is thought to be involved in substrate recognition. It was shown that USP11 co-purifies with human Polycomb Repressive Complex type 1 (PRC1) and regulates the stability of the E3 ligase component of PRC1 (Maertens et al, 2010). PRC1 repress transcription from the INK4a tumour suppressor locus. Hence knockdown of USP11 in primary human fibroblasts causes de-repression of INK4a, followed by a senescence-like proliferative arrest. In this project we aimed to map the interaction between USP11 and PRC1 components (BMI1, RING2, MEL18 and CBX8). We used two methods to investigate their interactions; yeast two-hybrid and in vitro pull down. Unexpectedly, we could not confirm a direct interaction between USP11 and any PRC1 component. We hypothesize that the lack of post-translation modifications, the presence of fusion tags and/or the need of a multi-subunit PRC1 complex might be needed to observe a high affinity interaction. We also aimed to map the interaction between three PRC1 components; RING2, BMI1 and RYBP, with the ultimate aim of solving the X-ray structure of the complex. The main obstacle in this project was to express, extract and purify these proteins at high levels in bacterial culture. Preliminary data suggests that RYBP and BMI1 do not interact directly. Here we report the 3.6 Å resolution X- ray structure of the human USP11 DU. The sequence linking the DUSP and UBL domains, the DU finger, could not be assigned in the electron density map due to low resolution. Comparison with the related USP4 DU crystal structure reveals that the structures are mostly conserved.
Interaction of NS3 with viral and host proteins and RNA during hepatitis C virus replication
Creators: name: Sifennasr, Nadia
Publisher: name: Imperial College London
Year: 2013

description: Hepatitis C virus (HCV) is a major cause of viral hepatitis. The World Health Organiz a- tion (WHO) estimates the global prevalence of HCV to be approximately 2.2–3.0% with 130– 170 million infected individuals worldwide. HCV has the ability to evade the i m- m une system and to establish persistent infections, which often result in chronic liver di s- ease. HCV encodes a long polyprotein which contain structural and non-structural pr o- teins. The Non-structural protein NS3 is likely to be involved in viral RNA replication by interacting with viral and host components. In this study, a purified recombinant full- length NS3 protein expressed in E. coli was examined for its ability to interact with bi otinylated full length HCV JFH-1 genomic RNA and the 3’ terminal of HCV negative strand RNA. The results showed that NS3 could bind to both full length and the 3’ end negative strand RNAs. RNA interference (siRNA) studies were also carried out to inve s- tigate the role of host genes RAB40B, RAB27B, TXNIP and Staufen 1, which had prev i- ously been shown to be important for HCV replication, on NS3 and NS3/4A proteins e x- pressed by adenovirus vectors using quantitative real-time polymerase chain reaction (qRT-PCR) and FACS analysis. While there were reductions in the levels of the NS3 and NS3/4A transcripts when the expression of these host genes was knocked down by siRNAs, the NS3 and NS3/4A proteins appeared to be more stable when RAB40B, RAB27B, but not TXNIP or Staufen 1, were knocked. One possibility is that although s i- lencing of these host genes may reduce HCV replication, this may also increase in the stability of NS3 or NS3/4A proteins by altering their location within the cell due to the absence of these host proteins. Previously it has been shown that NS3 and NS3/4A pr o- tein expression decreased the level of expression of several proteins, which were part of the innate immune response, leading to interferon production. In this study, it was found that the expression of NS3 and NS3/4A proteins, using adenovirus vectors, restored RIG- I, MDA5 and MAVS expression levels in response to dsRNA stimulation, indicating that the NS3 protein may have a role in regulating the expression of these host genes.
Chiral topological states in Bose-Fermi mixtures
Creators: name: Wu, Ying-Hai
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Topological states were initially discovered in solid state systems and have generated widespread interest in many areas of physics. The advances in cold atoms create novel settings for studying topological states that would be quite unrealistic in solid state systems. One example is that the constituents of quantum gases can be various types of bosons, fermions, and their mixtures. This paper explores interaction-induced topological states in two-dimensional Bose-Fermi mixture. We propose a class of topological states which have no fractionalized excitations but possess maximally chiral edge states. For previously known topological states, these two features can only be found simultaneously in the integer quantum Hall states of fermions and the $E_{8}$ state of bosons. The existences of some proposed states in certain continuum and lattice models are corroborated by exact diagonalization and density matrix renormalization group calculations. This paper suggests that Bose-Fermi mixture is a very appealing platform for studying topological states.
description: 10 pages, 8 figures
Molecular mechanisms and therapeutic perspectives of xenon in attenuating renal graft ischemia-reperfusion injury
Creators: name: Zhao, Halin
Publisher: name: Imperial College London
Year: 2013

description: Ischaemia-reperfusion injury (IRI) following prolonged hypothermic storage contributes to the occurrence of delayed graft function and progression of end-stage graft failure. The objective of my thesis is to evaluate xenon in preventing graft ischaemia-reperfusion injury in a rat model of kidney transplantation. The ultimate aim is to improve the long-term transplant outcome through preserving the graft quality. I have demonstrated that exposure of human proximal tubular cells (HK-2) to xenon activated IGF-1, HIF-1a, VEGF, HO-1, Bcl-2 and HSP-70. Xenon treatment prior to, or after, hypothermia-hypoxia challenge conferred protection against cell injury. In the Lewis to Lewis rat syngeneic renal grafts, xenon exposure before graft retrieval from donors or after engraftment in recipients decreased caspase-3 expression, and prevented TLR-4/NF-kB activation. The serum level of pro-inflammatory cytokines IL-1β, IL-6 and TNF-a was reduced and renal function was preserved. In the Brown-Norway to Lewis rat allogeneic renal grafts, xenon donor pre-treatment and recipient post-treatment decreased the renal tubular cell death, tubular inflammation and tubular MHC II expression. This in turn improved early graft function. T cell mediated alloresponse was therefore reduced. In combination with cyclosporine A, both xenon pre-treatment and xenon post-treatment prolonged the renal graft survival. In the Fischer-to-Lewis rat allogeneic grafts, xenon exposure to donors before graft retrieval or to recipients after engraftment enhanced tubular cell proliferation, decreased tubular cell death and graft inflammation associated with IRI. T cell infiltration and fibrosis were significantly suppressed with xenon treatment, chronic allograft nephropathy was attenuated. In summary, my thesis shows that either xenon donor pre-treatment or recipient post-treatment protected the renal graft against IRI, which in turn reduced acute immune rejection and attenuated chronic allograft nephropathy. This novel approach against IRI could be translated into clinical practice leading to considerable increase in viable organ availability and improvement in the long-term graft survival.
Spectroscopy of the roAp star Alpha-Cir -- II. The bisector and equivalent-width of the H-alpha line
Creators: name: Baldry, I. K.
name: Viskum, M.
name: Bedding, T. R.
name: Kjeldsen, H.
name: Frandsen, S.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present bisector measurements of the H-alpha line of the rapidly oscillating Ap (roAp) star, Alpha-Cir, obtained from dual-site observations with medium-dispersion spectrographs. The velocity amplitude and phase of the principal pulsation mode vary significantly, depending on the height in the H-alpha line, including a phase reversal between the core and the wings of the line. This supports the theory, suggested in Paper I, of a radial pulsational node in the atmosphere of the star. Blending with metal lines partially affects the H-alpha bisector results but probably not enough to explain the phase reversal. We have also detected changes in the equivalent-width of the line during the pulsation, and measured the oscillatory signal as a function of wavelength across the H-alpha region.
description: 13 pages, 14 figures, accepted by MNRAS
Structural studies of different form I Rubiscos using molecular dynamics simulations
Creators: name: De Manzanos Guinot, Angela
Publisher: name: Imperial College London
Year: 2016

description: Photosynthesis is the process by which autotrophic photosynthetic organisms utilise light energy to assimilate CO2 into biomass, releasing O2 into the atmosphere as a by-product. Even though photosynthetic reactions were crucial in the “Great Oxygenation Event” of our atmosphere 2.4 billion years ago, these greatly limit crop yields. Hence, increasing the photosynthetic efficiency of light conversion into biomass has become a crucial practice to feed the increasing global population. Rubisco is a fundamental enzyme in the carbon reactions of photosynthesis, which fixates atmospheric carbon dioxide into biomass. However, due to its slow turnover (3 molecules of CO2 fixed per second) and inhibition of carboxylation reactions by oxygenation, Rubisco is a major bottleneck of carbon fixation in photosynthesis. Rubisco form I from higher plants is the most abundant form of Rubisco on earth. It is a complex enzyme consisting of 8 large and 8 small subunits, which forms a hexadecameric structure with a mass of 550 kDa in higher plants. Due to Rubisco’s multimeric nature, targeted mutagenesis experiments to investigate more efficient catalysts in higher plants is extremely challenging. Furthermore, its eight active sites are located in the interface of the large subunits, a feature which further complicates the understanding of the events occurring in the active sites responsible for Rubisco’s catalytic inefficiencies. While molecular dynamics (MD) simulations can be used to investigate these inefficiencies, previous studies are limited by a 50 ns time frame, thereby lacking the ability to adequately capture the underlying structural dynamics. For the first time, this thesis presents 17 long MD simulations, ranging from 500-1500 ns, using 13 different structures of Rubisco form I from three distinct organisms (Synechoccocus, spinach and Chlamydomonas). It provides evidence of the suitability of this technique in inspecting the impact of different mutants of Rubisco on the RuBP substrate’s binding affinity. For this purpose, results were compared to existing experimental data of mutant forms of Rubisco. The essays hereby reported demonstrate that, after long MD simulations of Rubisco, the resulting binding affinity ranking of the substrate to different mutants is consistent with previous experimental work. Moreover, the simulations reveal an allosteric behaviour of the substrate binding between the eight active sites of Rubisco, and verify the influence of Rubisco’s structural elements on the binding affinity of its substrate.
Picus hirundinaceus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Piciformes
Picidae
Picus
Picus hirundinaceus

description: Picus hirundinaceus [spec. nov.]
P. niger, occipite coccineo, humeris albido punctatis.
Picus secundus niger. Alb. av. 3. p. 22. t. 23.
Habitat in America septentrionali.
Magnitudine vix Hirundinem superat.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 113, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 2 of Switching from TNFα inhibitor to tacrolimus as maintenance therapy in rheumatoid arthritis after achieving low disease activity with TNFα inhibitors and methotrexate: 24-week result from a non-randomized, prospective, active-controlled trial
Creators: name: Jung, Sang Youn
name: Koh, Jung Hee
name: Kim, Ki-Jo
name: Park, Yong-Wook
name: Yang, Hyung-In
name: Choi, Sung Jae
name: Lee, Jisoo
name: Choi, Chan-Bum
name: Kim, Wan-Uk
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2:. Supplementary methods and results
rice_seedlings_and_weeds_datarice_seedlings_and_weeds_data
Creators: name: Xiangwu Deng
name: Ma, Xu
name: Qi, Long
name: Jiang, Yu
name: Xupo Xing
name: Hongwei Li
Publisher: name: figshare
Year: 2018
Subjects: subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: The images of rice seedlings and six weeds in the paddy field.
History of Archimedean and non-Archimedean approaches to uniform processes: Uniformity, symmetry, regularity
Creators: name: Bottazzi, Emanuele
name: Katz, Mikhail G.
Publisher: name: arXiv
Year: 2025
Subjects: subject: History and Overview (math.HO)
subject: Logic (math.LO)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 03H05, 03H10, 00A30, 60A05, 26E30, 01A65

description: We apply Nancy Cartwright's distinction between theories and basic models to explore the history of rival approaches to modeling a notion of chance for an ideal uniform physical process known as a fair spinner. This process admits both Archimedean and non-Archimedean models. Advocates of Archimedean models maintain that the fair spinner should satisfy hypotheses such as invariance with respect to rotations by an arbitrary real angle, and assume that the optimal mathematical tool in this context is the Lebesgue measure. Others argue that invariance with respect to all real rotations does not constitute an essential feature of the underlying physical process, and could be relaxed in favor of regularity. We show that, working in ZFC, no subset of the commonly assumed hypotheses determines a unique model, suggesting that physically based intuitions alone are insufficient to pin down a unique mathematical model. We provide a rebuttal of recent criticisms of non-Archimedean models by Parker and Pruss.
description: 40 pages. To appear in Antiquitates Mathematicae
Additive manufacturing of locally resonant metamaterials
Creators: name: Raza, Irfan Mohammad Hussain
Publisher: name: Imperial College London
Year: 2017

description: For many engineering applications, vibrations and sound can cause a multitude of issues. Several methods for damping out these vibrations are utilised today such as insulation foam used in walls or heavy granite bases for machinery and optical equipment. More recently, the development of acoustic and elastic metamaterials has shown the possibility to manipulate propagating waves in ways that were not previously possible, such as wave attenuation at an exponential rate. Locally Resonant Metamaterials (LRMs) have been shown to attenuate waves with wavelengths two orders of magnitude greater than the lattice constant of the LRM, making them well suited for low frequency applications. They typically consist of a core, an elastic lining, and a matrix material. Much of the research into LRMs is modelling based, with fewer experimental results to correctly verify different designs. One reason for this is that the manufacture of LRMs can be difficult as they require multiple material properties, and design consistency, particularly as the LRM geometries become more complex. Additive manufacturing (aka 3D printing) promises the ability to make complex shapes reliably and repeatedly. Hence, 3D printing techniques could be used to make LRMs. In this project, a custom built 3D printer is developed, which utilises different deposition techniques to allow it to manufacture an LRM. This facilitates the fabrication of more varied designs of metamaterial, which would have been too impractical otherwise to manufacture. The printer is fully customisable in LabVIEW and utilises a unique `point-cloud' method to process part geometry. More recently, active applications of LRMs have been explored to achieve behaviours that passive metamaterials cannot. One subset of active metamaterials is the growing field of metamaterial energy harvesting. This is the principle that metamaterials can be used to convert vibrations and sound into another form of usable energy, such as electricity. Two concepts are introduced which use an LRM type design with a magnetic core. By the phenomenon of electromagnetic induction, as a propagating wave induces a periodic displacement on the core, a current is induced in adjacent wires which could potentially be stored for later use in an application.
Picus erythrocephalus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Piciformes
Picidae
Picus
Picus erythrocephalus

description: Picus erythrocephalus [spec. nov.]
P. capite toto rubro, alis caudaque nigris, abdomine albo.
Picus capite toto rubro. Catesb. car. 1. p. 20. t. 20.
Habitat in America.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 113, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206