title: ÐÐ¿ÑÐ¸Ð¾ÑÐ½ÑÐµ Ð¾ÑÐµÐ½ÐºÐ¸ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐ½Ð¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ Ð±Ð¸Ð¾Ð¼Ð¾Ð»ÐµÐºÑÐ»
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Priori estimates of the thermal stability of biomolecules
Creators: name: ÐÐ»ÑÑÐºÐ¾Ð²ÑÐºÐ°Ñ, Ð®Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐºÐ¾Ð½ÑÑÐ°Ð½ÑÐ° ÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ¸Ñ
ÑÐ¾Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ðµ ÐÑÑÐµÐ½Ð¸ÑÑÐ°
composition constant
Arrhenius equation

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description: The subject of the graduate qualification work is âPriori estimates of the thermal stability of biomoleculesâ. The work is devoted to finding the basic minimum of experimental information about biomolecules, that is necessary for assessing the physical parameters of the biological environment and their temperature dependences. As part of the work performed, the published data related to theoretical descriptions of the processes of thermal dissociation of quasi-diatomic molecules and recombination of their fragments were analyzed. The conclusion about the difficulty of a purely theoretical quantitative ab initio description of thermal dissociation processes is justified. A model of an indirect experiment was built using literature data.As a result, the possibility of obtaining the dependence of the degree of association of the SARS-CoV-2 protease dimer on temperature, the absolute concentration of the "dry" substance of this dimer, as well as the energy of dissociation of the dimer, based on the temperature dependence of the monomer concentration known from the experiment, has been shown.