cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
C. elegans as a platform to characterize genes and therapeutics affecting genome stability
Creators: name: Ye, Bin
Publisher: name: University of British Columbia
Year: 2021

description: Genome stability is essential for survival in all living organisms. Perturbations of genome stability can lead to cancer and other diseases in human. Dysfunction of genome care-taking genes and exposure to external genotoxins are the two major drivers of genomic instability. Here, we used a model organism, C. elegans to study these factors and how they interact to affect genome stability. We first generated a chemi-genetic interaction map as a preliminary reference for characterizing genes and agents. From there, we elucidated the mechanisms of action for an emerging anticancer therapeutic CX-5461. CX-5461 turned out to be a multi-modal agent that exhibits genotypic sensitivity, mutagenicity and photosensitivity. Next, we identified a few genetic interactions within and between double-strand break repair pathways in C. elegans, which have implications in the response to both endogenous and exogenous DNA damage. We also characterized a less-understood gene SMRC-1, an annealing helicase. Loss of SMRC-1 results in copy number variations, and SMRC-1 is synthetic lethal with a number of DNA damage response genes. Our work concludes that C. elegans is a great platform to untangle the sophisticated complexity in genome maintenance, and provide meaningful insights for prospective anticancer therapeutic development.
Additional file 1 of Breastfeeding, first-food systems and corporate power: a case study on the market and political practices of the transnational baby food industry in Brazil
Creators: name: Robles, Cindy Alejandra Pachón
name: Mialon, Mélissa
name: Mais, Laís Amaral
name: Neri, Daniela
name: Silva, Kimielle Cristina
name: Baker, Phillip
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1
Relation Between Globular Clusters and Supermassive Black Holes in Ellipticals as a Manifestation of the Black Hole Fundamental Plane
Creators: name: Snyder, Gregory F.
name: Hopkins, Philip F.
name: Hernquist, Lars
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We analyze the relation between the mass of the central supermassive black hole (Mbh) and the number of globular clusters (Ngc) in elliptical galaxies and bulges as a ramification of the black hole fundamental plane, the theoretically predicted and observed multi-variable correlation between Mbh and bulge binding energy. Although the tightness of the Mbh-Ngc correlation suggests an unlikely causal link between supermassive black holes and globular clusters, such a correspondence can exhibit small scatter even if the physical relationship is indirect. We show that the relatively small scatter of the Mbh-Ngc relation owes to the mutual residual correlation of Mbh and Ngc with stellar mass when the velocity dispersion is held fixed. Thus, present observations lend evidence for feedback-regulated models in which the bulge binding energy is most important; they do not necessarily imply any `special' connection between globular clusters and Mbh. This raises the question of why Ngc traces the formation of ellipticals and bulges sufficiently well to be correlated with binding energy.
description: 7 pages, 2 figures, accepted for publication in ApJL
Preliminary Optics Investigation for ALMA Multibeam Receiver
Creators: name: Haoran Kang
Publisher: name: Zenodo
Year: 2021
Subjects: Multibeam Receiver
Atacama Large Millimeter/submillimeter Array

description: This presentation introduced a possible solution for multibeam receiver optics of ALMA. This design is based on frequency independent concept, and it is demonstrated by physical optics simulation, by using this design concept, we can realize almost constant aperture efficiency in >50% fraction bandwidth, which covers two current ALMA frequency bands.
title: Traumatic hand finger injuries in labor accident: Imaging findings review.
Creators: name: Converti, Agustina
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Musculoskeletal joint
subject: MR
subject: eLearning
subject: Motility

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: A systematic recap of the different findings in MRI scans in patients with traumatic injury of the finger joints, that occurred in work context, will be described as a practical guide to discriminate the most important ligament injuries and their...
Fisa descriere si cheie de identificare pentru specia Amorpha fruticosa
Creators: name: Pioarca-Ciocanea, C.M.
name: Manolache, A.S.
name: Anastasiu, P.
name: Rozylowicz, L.
name: Manta, N.
Publisher: name: Zenodo
Year: 2020
Subjects: specii invazive
invasive alien species
Amorpha fruticosa
salcam pitic

description: Fisa descriere si cheie de identificare pentru specia Amorpha fruticosa
description: Managementul adecvat al speciilor invazive din România, în conformitate cu Regulamentul UE 1143/2014 referitor la prevenirea și gestionarea introducerii și răspândirii speciilor alogene invazive, POIM 2014+ 120008, 2018-2022. http://invazive.ccmesi.ro/
title: Quantification of organ motion with magnetic resonance imaging (MRI) in carbon ions therapy (CIRT) of the abdominal district.
Creators: name: Anemoni, Luca
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Abdomen
subject: Oncology
subject: Radiographers
subject: CT
subject: MR
subject: Radiation safety
subject: Radiation therapy / Oncology
subject: Radiobiology
subject: Pathology
subject: Radiotherapy techniques

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Hadrontherapy is a specific kind of radiotherapy which uses heavy and charged ions to make damage in carcinogenic cells. At CNAO, we deliver in clinical practice protons and carbon ions.The treatment of tumors through hadrontherapy implies the use...
Generalized conditional symmetries of evolution equations
Creators: name: Kunzinger, Michael
name: Popovych, Roman O.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 35B06 (Primary) 35K55, 35K57, 35C05 (Secondary)

description: We analyze the relationship of generalized conditional symmetries of evolution equations to the formal compatibility and passivity of systems of differential equations as well as to systems of vector fields in involution. Earlier results on the connection between generalized conditional invariance and generalized reduction of evolution equations are revisited. This leads to a no-go theorem on determining equations for operators of generalized conditional symmetry. It is also shown that up to certain equivalences there exists a one-to-one correspondence between generalized conditional symmetries of an evolution equation and parametric families of its solutions.
description: 23 pages, extended version
title: Can MR Urography be an alternate for CT Urography?
Creators: name: Rastogi, Rajul
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Kidney
subject: Urinary Tract / Bladder
subject: CT
subject: MR
subject: Comparative studies
subject: Diagnostic procedure
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Introduction Urinary tract (UT) pathologies are common causes of morbidity presenting mainly as acute flank pain, obstructive uropathy, and hematuria with calculus being the commonest cause. Computed tomography (CT) (noncontrast, contrast enhanced...
АНАЛИЗ НАДЕЖНОСТИ МНОГОУРОВНЕВЫХ СЕТЕЙ С НЕНАДЕЖНЫМИ ВЕРШИНАМИ
Creators: name: Кальней Артем Максимович
name: Алексей Сергеевич Родионов
Publisher: name: Проблемы информатики
Year: 2020
Subjects: многоуровневые сети
моделирование
гиперсети
анализ надежности.

description: Рассматриваются вопросы расчета показателей надежности многоуровневых сетей е ненадежными вершинами. Представление показатели: вероятность связности нары узлов сети, средняя арифметическая вероятность связности нары узлов сети (АРС), средний размер связного подграфа, содержащих) выделенную вершину (ASCS). Для математического описания многоуровневых сетей используется гиперсеть. Был разработан алгоритм на основе известных методов расчета сети е ненадежными элементами. В статье приведен пример работы алгоритма для показателя ASCS, который показывает возможность его использования для оптимизации расстановки датчиков мониторинга окружающей среды части транспортной сети Новосибирска.
РЕЗУЛЬТАТЫ ЧИСЛЕННЫХ ЭКСПЕРИМЕНТОВ ПО МОДЕЛИРОВАНИЮ МАГНИТОТЕЛЛУРИЧЕСКОГО ПОЛЯ В ВЕРТИКАЛЬНО ГРАДИЕНТНОЙ СРЕДЕ
Creators: name: Забинякова Ольга Борисовна
name: Скляр Сергей Николаевич
Publisher: name: Проблемы информатики
Year: 2020
Subjects: прямая одномерная задача магнитотеллурического зондирования
вертикально градиентная среда
метод локальных интегральных уравнений
численные эксперименты

description: В работе представлены результаты численных экспериментов но решению прямой одномерной задачи магнитотеллурического зондирования для вертикально градиентной среды с разными вариантами постановки краевых условий. Вычисления осуществлялись в матричной форме в среде Mat lab с помощью алгоритмов, полученных на основе метода локальных интегральных уравнений.
Evidence for forward scattering and coupling to acoustic phonon modes in high-T$_c$ cuprate superconductors
Creators: name: Johnston, S.
name: Vishik, I. M.
name: Lee, W. S.
name: Schmitt, F.
name: Uchida, S.
name: Fujita, K.
name: Ishida, S.
name: Nagaosa, N.
name: Shen, Z. X.
name: Devereaux, T. P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Recent laser angle-resolved photoemission spectroscopy studies have established the presence of a new kink in the low-energy nodal dispersion of Bi$_2$Sr$_2$CaCu$_2$O$+{8+δ}$ (Bi-2212). The energy scale (~8-15 meV) of this kink appears below the maximum of the superconducting gap $δ_0$. Therefore it is difficult to interpret this feature in terms of the usual coupling to a sharp dispersionless mode. In this paper we examine electron-phonon coupling to the in-plane acoustic phonon branch arising from the modulation of the screened Coulomb potential. We demonstrate that such a coupling has a strong forward scattering peak, and as a consequence, a kink occurs in the dispersion at an energy scale shifted by the local gap $δ(k)$. In addition, considerations for the reduction of screening with underdoping naturally explains the observed doping dependence of the low-energy kink. These results point to a strong coupling to the acoustic branch which is peaked in the forward scattering direction and has important implications for transport and pairing in the high-T$_c$ cuprates.
description: 4.5 pages, 4 figures, Submitted to PRL
title: Analysis of white matter DTI metrics with clinical correlations in patients with essential tremor submitted to MRgFUS thalamotomy
Creators: name: Bruno, Federico
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: CNS
subject: MR-Functional imaging
subject: Imaging sequences
subject: Image verification

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: MRgFUS thalamotomy is an innovative, minimally invasive, ablation technique clinically approved for the treatment of essential tremor and Parkinson's disease tremor. The procedure involves the use of focused high-intensity ultrasound beams to target...
title: Data-driven energy modeling of a dynamical system
title: Energy modeling with neural networks on the example of an industrial robot
titleType: Subtitle
Creators: name: Steurer, Philipp
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2021
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften

description: The purpose of an energy model is to predict the energy consumption of a real system and to use this information to address challenges such as rising energy costs, emission reduction or variable energy availability. Industrial robots account for an important share of electrical energy consumption in production, which makes the creating of energy models for industrial robots desirable. Currently, energy modeling methods for industrial robots are often based on physical modeling methods. However, due to the increased availability of data and improved computing capabilities, data-driven modeling methods are also increasingly used in areas such as modeling and system identiﬁcation of dynamic systems. This work investigates the use of current data-driven modeling methods for the creation of energy models focusing on the energy consumption of industrial robots. For this purpose, a robotic system is excited with various trajectories to obtain meaningful data about the system behavior. This data is used to train diﬀerent artiﬁcial neural network (ANN) structures, where the structures used can be categorized into (i) Long Short Term Memory Neural Network (LSTM) with manual feature engineering, where meaningful features are extracted using deeper insights into the system under consideration, and (ii) LSTM with Convolutional layers for automatic feature extraction. The results show that models with automatic feature extraction are competitive with those using manually extracted features. In addition to the performance comparison, the learned ﬁlter kernels were further investigated, whereby similarities between the manually and automatically extracted features could be observed. Finally, to determine the usefulness of the derived models, the best-performing model was selected for demonstrating its performance on a real use case.
О региональной фагологии
Creators: name: Елистратов Владимир Станиславович
Publisher: name: Еда и культура
Year: 2015
Subjects: региональная фагология
танатофагия
эротофагия
regional fagology
tanatofagia
erotofagia

description: Данная статья посвящена описанию антиномий региональных гастрономических систем. В статье предлагается оригинальная терминологическая система («фагология», «фагокультура», «региональная фагосистема» и др.), которая дает возможность методоллогически более точно и глубоко описать мировую культуру еды.
description: This article is devoted to the description of the antinomies of gastronomic regional systems. The article suggests the original terminological system («fagology», «fagoculture», «regional fagosystem» and others), enabling a more methodologically accurately and deeply describe the world food culture.
ПРОГРАММНОЕ ОБЕСПЕЧЕНИЕ ДЛЯ ОБНАРУЖЕНИЯ ГРАНИЦ НА ПРИМЕРЕ ИЗОБРАЖЕНИЙ СЕЙСМИЧЕСКОГО ВОЛНОВОГО ПОЛЯ
Creators: name: Якименко Александр Александрович
name: Макфузова Анна Игоревна
name: Михайленко Дмитрий Александрович
Publisher: name: Проблемы информатики
Year: 2020
Subjects: обнаружение границ
распознавание изображений
нейроная есть
неокогнитрон

description: В статье производится оценка эффективности программного обеспечения (ПО) для обнаружения границ на примере изображений картин сейсмического волнового ноля. Для обнаружения границ на изображениях применяются фильтры Соболя, Превитта, Робертса, Габора и алгоритм Канин. Оценка ПО производится количественными и качественными характеристиками. Результаты будут использованы в работе но исследованию нейронной сети неокогнитрон для распознавания геолого-физических моделей сред (ГФМС).
On the effects of microphysical grain properties on the yields of carbonaceous dust from type II SNe
Creators: name: Fallest, David W.
name: Nozawa, Takaya
name: Nomoto, Ken'ichi
name: Umeda, Hideyuki
name: Maeda, Keiichi
name: Kozasa, Takashi
name: Lazzati, Davide
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the role of the unknown microphysical properties of carbonaceous dust particles in determining the amount and size distribution of carbonaceous dust condensed in type II supernova explosions. We parametrize the microphysical properties in terms of the shape factor of the grain and the sticking coefficient of gas-phase carbon atoms onto the grain surfaces. We find that the amount of dust formed is fairly independent of these properties, within the parameter range considered, though limited by the available amount of carbon atoms not locked in CO molecules. However, we find that the condensation times and size distributions of dust grains depend sensitively on the microphysical parameters, with the mass distributions being weighted toward larger effective radii for conditions considering grains with higher sticking coefficients and/or more aspherical shapes. We discuss that this leads to important consequences on the predicted extinction law of SN dust and on the survival rate of the formed grains as they pass through the reverse shock of the SN. We conclude that a more detailed understanding of the dust formation process and of the microphysical properties of each dust species needs to be achieved before robust prediction on the SN dust yields can be performed.
description: 13 pages, 18 figures
title: Perceptions and perspectives of therapeutic radiographers on the use of Artificial Intelligence in a Clinical Setting –a UK study
Creators: name: McFadden, Sonyia
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Artificial Intelligence
subject: Professional issues
subject: Radiographers
subject: Gamma knife
subject: Decision analysis
subject: Education
subject: Technology assessment
subject: Cancer
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: [fig]5[/fig] Radiotherapy involves complex treatment planning and delivery techniques and processes. Artificial Intelligence (AI) solutions in radiotherapy include automated contouring, autoplanning for dosimetry, synthetic generation of planning...
title: Entwicklung einer Open-Source Programmierhilfe für Roboterzellen
Creators: name: Lerchbaumer, Thomas
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2021
Subjects: subject: 004 Informatik

description: Die Arbeit beschreibt die Entwicklung eines Open-Source Plugins für die 3D-Modellierungssoftware FreeCAD, mit welchem es möglich ist, Roboterpfade anhand von 3D-Modellen zu erstellen. Die Pfade sind in einem geeigneten Format exportierbar und können beispielsweise zur Steuerung eines Roboters durch eine speicherprogrammierbare Steuerung verwendet werden. Im ersten Teil der Arbeit wird der geplante Arbeitsablauf der Pfadgenerierung beschrieben und genauer erläutert, welche Vorteile und Pflichten die Erstellung von Open-Source-Software nach sich zieht. Anschließend wird anhand der Systeme „Robot Studio“ von ABB und „MotoSim EG VRC“ von Yaskawa analysiert, wie proprietäre Systeme die Programmierung von Roboterpfaden realisieren. Nach einem Überblick über den aktuellen Stand der Technik in der Roboterprogrammierung, wird die Implementierung des Plugins für FreeCAD beschrieben. Dazu wird anhand des Sourcecodes erläutert, wie neue Arbeitsbereiche erstellt werden können. Es werden verschiedene Funktionen implementiert, welche essenziell für die Erstellung von Roboterpfaden sind. Dazu zählen die Möglichkeit zur Definition von Koordinatensystemen, Roboterposen und das Beschreiben des Roboterpfades durch Pfadsegmente mit verschiedenen Parametern, wie Bewegungsart, Geschwindigkeit und Wegpunkte. Das Plugin wurde getestet indem eine einfache Pick & Place Anwendung erstellt wurde. Anschließend sind mögliche Erweiterungen des Plugins, wie zum Beispiel die Möglichkeit des Duplizierens von Pfadsegmenten am Ende der Arbeit beschrieben.
title: Non-contrast CT-based Radiomics: Predicting renal function in patients with atherosclerotic renal artery stenosis undergoing endovascular treatment
Creators: name: Fu, Jia
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Abdomen
subject: Arteries / Aorta
subject: Kidney
subject: CT
subject: Angioplasty
subject: Angioscopy
subject: Arterial access
subject: Developmental disease
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Atherosclerotic renal artery stenosis (ARAS) is the prominent cause of renal artery stenosis[1]. Sever renal artery stenosis can be asymptomatic [2].Therefore ,majority newly diagnosed patients were suffer from serious complications such as...
title: SysML Modellierung komplexer Systeme und automatische Erzeugung domänenspezifischer Ressourcen
Creators: name: Franz, Sebastian
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2021
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften

description: Moderne Technische Systeme und ihre Entwicklung werden zunehmend komplexer. Durch eine Vielzahl bei der Entwicklung beteiligter Modelle/Dokumente wird eine konsistente und rückverfolgbare Modellierung erschwert. Model-Based Systems Engineering (MBSE) ist ein Ansatz, welcher diese Problemstellung adressiert und bei der Systementwicklung formale Modelle anstelle von Dokumenten einsetzt/verwendet. Im Gegensatz zu Dokumenten sind Modelle formal definiert, können automatisiert überprüft werden und ermöglichen eine leichte maschinelle Verarbeitung der Informationen. Im Zentrum der Entwicklung steht ein Systemmodell, welches mit einer formalen Modellierungssprache erstellt wurde. Während der Entwicklung entstehende Informationen werden in das Systemmodell integriert, sodass eine konsistente Single Source of Truth entsteht. Aus dem Systemmodell können über automatisierte Modelltransformationen domänenspezifische Ressourcen, wie beispielsweise Digital Twins, generiert werden. Digital Twins und die damit verbundenen Simulationen können einen deutlichen Mehrwert in Bereichen, wie Optimierung, Wartung und Anomalieerkennung liefern. Allerdings ist die manuelle Erzeugung Aufwändig und Fehleranfällig sein, weshalb eine automatische Erzeugung aus den Informationen des Systemmodells eine Erleichterung darstellt. Diese Arbeit beschäftigt sich mit dieser Problemstellung und der Modellierung komplexer Systeme. Es wird ein Systemmodell mit der Modellierungssprache Systems Modeling Language (SysML) erstellt, welches durch domänenspezifische Profile erweitert wird um Modellierung/Integration der Domänen zu ermöglichen. Mittels einer Modelltransformation in Acceleo werden Informationen aus dem Systemmodell in ein Simulationsmodell der Simulationssoftware twin, welche zur Simulation von Digital Twins geeignet ist, transformiert. Der in der Arbeit präsentierte Ansatz wird anhand er Modellfabrik des Forschungszentrums Digital Factory Vorarlberg veranschaulicht.
title: Accelerated 3D PDWI in knee imaging: Quality and efficiency of a deep learning-based Compressed SENSE reconstruction
Creators: name: Mu, Lin
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Musculoskeletal joint
subject: MR
subject: CAD
subject: Imaging sequences
subject: Technology assessment
subject: Artifacts
subject: Athletic injuries
subject: Image verification

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The purpose of the study is to determine the feasibility of 3D PDWI accelerated with Compressed-SENSE Artificial Intelligence (CS-AI) for evaluating the knee image quality, scan time and compared with SENSE and standard Compressed-SENSE with...
title: Evaluation of Levator Hiatus by MRI
Creators: name: Rastogi, Rajul
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Anatomy
subject: Genital / Reproductive system female
subject: Pelvis
subject: MR
subject: Diagnostic procedure
subject: Screening
subject: Pelvic floor dysfunction

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Introduction Levator hiatus is the largest potential hernial portal in the human body. Excessive distensibility is associated with female pelvic floor dysfunction (PFD). PFD which includes conditions like Pelvic Organ Prolapse, Stress Urinary...
ПРОГРАММНАЯ СРЕДА И МЕТОДИКА РАЗРАБОТКИ ИНТЕЛЛЕКТУАЛЬНЫХ СППР
Creators: name: Загорулько Галина Борисовна
Publisher: name: Проблемы информатики
Year: 2020
Subjects: разработка интеллектуальных СППР
онтология
оболочка СППР
фреймворк
информационно-аналитический интернет-ресурс

description: В статье рассматриваются наиболее известные доступные программные среды, используемые для построения интеллектуальных СППР, jColibri и CLIPS, анализируются их назначение, функциональные возможности, области использования. Подробно описывается фреймворк СПОРА+, предназначенный для комплексной поддержки разработки интеллектуальных СППР. Описываются модель комплексной поддержки и предлагаемые ею средства онтология поддержки принятия решений, информационно-аналитический интернет-ресурс, репозиторий методов поддержки принятия решений и методика разработки интеллектуальных СППР. Предлагаемые средства основываются на принципах и подходах, хорошо зарекомендовавших себя при разработке систем такого класса, и используют технологии разработки интеллектуальных научных интернет-ресурсов и Semantic Web. Описываются методика и алгоритм использования СПОРА+. Подчеркиваются отличительные особенности данного фреймворка.
The immune microenvironment of sarcomas : a comprehensive evaluation of infiltrating immune cells and checkpoint biomarkers in musculoskeletal tumors
Creators: name: Dancsok, Amanda R
Publisher: name: University of British Columbia
Year: 2019

description: Sarcomas are aggressive cancers of the connective tissues, such as bone, muscle, cartilage, and fat. Despite their diverse origins, sarcomas are predominantly treated by surgery and radiation, as conventional chemotherapy has limited benefit for most subtypes. When sarcomas recur or metastasize, there are few options for systemic therapy, and prognosis is very poor. Despite advancements in our understanding of the molecular drivers of sarcomas, almost no new treatments have proven benefit for metastatic sarcomas. Immunotherapy has shown value for other cancers, such as melanoma and lung cancer; however, sarcomas lag behind the common cancers in our understanding of their immune microenvironment and potential for treatment with immunotherapeutics. Early trials using single-agent immune checkpoint inhibitors in sarcomas delivered mixed results, but these studies somewhat indiscriminately lumped together different sarcoma subtypes that might have critical immunological differences. My study employs tissue microarrays incorporating 1360 sarcoma specimens (spanning 23 subtypes) to characterize immune infiltrates and expression of targetable immune biomarkers, using immunohistochemistry. Genomically-complex sarcoma types – driven by mutations and/or copy-number alterations – are found to have much higher levels of lymphocytic and phagocytic immune infiltrates than translocation-associated sarcomas. Across nearly all subtypes, tumor-associated macrophages outnumber tumor-infiltrating lymphocytes, predominately M2 (anti-inflammatory) macrophages. Expression of the target of first-generation immune checkpoint PD-(L)1 is uniformly low, but expression of LAG-3 and TIM-3 – emerging immune checkpoints – is significantly more common. Expression of anti-phagocytic immune checkpoint CD47 is yet more predominant, displaying all-or-nothing expression with 100% positivity seen in over half of positive cases. To further characterize the lymphocytic response, T-cell receptor (TCR) sequencing was performed on specimens from 25 sarcoma patients on a clinical trial of tremelimumab (anti-CTLA-4) with durvalumab (anti-PD-L1). We found that the TCR repertoire is richer and more diverse among the genomically-complex sarcomas relative to the translocation-associated sarcomas, and following immune checkpoint blockade, we observed an overall increase in the clonality of the peripheral TCR repertoire. My study demonstrates a tangible positive relationship between genomic complexity and immunogenicity, and highlights novel immune checkpoints of relevance to sarcomas. As such, this work provides the essential translational background to direct the use of immunotherapy in sarcoma management.
title: Untersuchung von Schankanlagen
title: Vermessung, Simulation und Konzepte zur Optimierung
titleType: Subtitle
Creators: name: Pfefferkorn, Simon
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2021
Subjects: subject: 620 Ingenieurwissenschaften und Maschinenbau

description: Im Rahmen dieser Masterthesis wurde beispielhaft gezeigt, mit welchen Maßnahmen die Handhabung (Gewicht, Größe) von Nasskühlern verbessert werden kann. Dabei wurde berücksichtigt, dass Kühlleistung und Durchsatz dem aktuellen Stand der Technik entsprechen. Die zu Beginn durchgeführten Messungen an einem, in der Praxis eingesetzten, Referenzgerät und die darauffolgenden Berechnungen lieferten die thermodynamischen Größen (Temperatur, Druck). Diese physikalischen Größen lieferten die Randbedingungen der darauffolgenden Computational Fluid Dynamics (kurz CFD) Simulationen. Aus technischen Gründen wurde der Druck nicht direkt über Sensoren gemessen, sondern mit Hilfe der gemessenen Temperaturen berechnet. Da die Druckmessung einen zu starken Eingriff ins System dargestellt hätte. Um die Korrektheit der berechneten Drücke sicherzustellen, wurden in weiterer Folge die Temperaturen nachgerechnet und mit den Messwerten verglichen. Um die Messwerte beziehungsweise die Berechnungen weiter zu bestätigen, ist zuerst ein CAD-Modell des vorhanden Referenzgerätes erstellt worden. Dieses CAD-Modell wurde dann hergenommen, um die ersten CFD Simulationen durchzuführen. Die Schwierigkeit hierbei lag bei der realistischen Abbildung der physikalischen Vorgänge, wie beispielsweise bei dem Verdampfen und Kondensieren des Kältemittels (Arbeitsmedium). Es wurden die einzelnen Komponenten des Kältekreislaufes simuliert (Wärmetauscher des Nutzmediums, Verdampfer und Kondensator des Arbeitsmediums). Abschließend wurde ein Entwurf zur Optimierung von Schankanlagen erarbeitet. Von diesen wurden (teilweise) CAD Modelle erstellt. Die Modelle der optimierten Komponenten wurden dann, bezogen auf ihr Volumen und Gewicht, mit denen des Referenzgerätes, gegenübergestellt. Den Abschluss der Arbeit bildet ein Fazit über die durchgeführten Berechnungen, Messungen und Simulationen. Des Weiteren wurden hier Aspekte, die nicht in der Arbeit berücksichtigt wurden, kurz aufgegriffen und erläutert.
Process Evaluation of the Integrated Childsmile Programme. Report of the first tranche of fieldwork (August 2010 to June 2011)
Creators: name: Eaves, Jennifer
name: Williams, Nicola
name: Deas, Leigh
name: Mattu, Leanne
name: Robertson, Lynn
name: Buch Larsen, Helle
name: Gnich, Wendy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine

description: This report provides findings from the first tranche of the process evaluation of the integrated Childsmile programme, covering the period August 2010 to June 2011.
Childsmile is the national, early years oral health improvement in Scotland. It comprises interacting components (Core: toothbrushing in all nurseries and targeted primary schools, provision of oral health packs at key stages; Nursery & School: fluoride varnishing provided to children in targeted educational establishments; and Practice: support for families with young children to register with and attend dental practices and to engage in protecting their children's oral health).
The purpose of the process evaluation is to explore implementation of the programme, to aid the interpretation of its outcomes.
title: MR imaging in parotid tumors
Creators: name: Elma, Sara
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Head and neck
subject: MR
subject: Biopsy
subject: Cancer
subject: Cysts

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Imaging of parotid gland tumors is challenging due to the wide variety of differential diagnoses. Malignant parotid tumors can have very similar features to benign ones, and may not be clinically distinguishable. Correct characterization of parotid...
The spin parameter of uniformly rotating compact stars
Creators: name: Lo, Ka-Wai
name: Lin, Lap-Ming
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the dimensionless spin parameter $j (= c J/ (G M^2))$ of uniformly rotating neutron stars and quark stars in general relativity. We show numerically that the maximum value of the spin parameter of a neutron star rotating at the Keplerian frequency is $j_{\rm max} \sim 0.7$ for a wide class of realistic equations of state. This upper bound is insensitive to the mass of the neutron star if the mass of the star is larger than about $1 M_\odot$. On the other hand, the spin parameter of a quark star modeled by the MIT bag model can be larger than unity and does not have a universal upper bound. Its value also depends strongly on the bag constant and the mass of the star. Astrophysical implications of our finding will be discussed.
description: Minor changes to match the published version
BigDataGrapes D4.2 - Methods and Tools for Distributed Inference
Creators: name: Yankova, Milena
name: SImeonov, Boyan
name: Kiryakov, Atanas
name: Alexiev, Vladimir
Publisher: name: Zenodo
Year: 2019
Subjects: data security; access rights; data inference

description: The objective of this deliverable is to develop inference methods that support efficient information selection from heterogeneous data pools. There are many challenges in data reasoning and inference based on distributed data. The first one is addressing data security and access rights to both original data and inferred information. The second challenge is how the actual inference over distributed sources can be performed and implemented. We address the main principles applied to data inference and different types of inference – rule-based, query-based, model-based and fuzzy inference – and their application in BigDataGrapes project. The Final section is dedicated to state of the art with a standard theoretical approach to inference from descriptive logic standpoint, as well as related work in implementing those approaches.
title: Predictive maintenance for test tower
title: Analysis of suitability of a predictive maintenance strategy for an electrical test tower
titleType: Subtitle
Creators: name: Sayfutdinov, Gabdelgaziz
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2021
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften

description: This paper analyses an electrical test tower of the OMCIRON electronics GmbH and evaluates whether a Predictive Maintenance (PdM) strategy can be implemented for the test towers. The company OMICRON electronics GmbH performs unit tests for its devices on test towers. Those tests consist of a multitude of subtests which all return a measurement value. Those results are tracked and stored in a database. The goal is to analyze the data of the test towers subtests and evaluate the possibility of implementing a predictive maintenance system in order to be able to predict the RUL and quantify the degradation of the test tower. By assuming that the main degradation source are the relays of the test tower, a reliability modelling is performed which is the model-driven approach. The data-driven modelling process of the test tower consists of multiple steps. Firstly, the data is cleaned and compromised by removing redundances and optimizing for the best subtests where a subtest is rated as good if the trendability and monotonicity metric values are above a specific threshold. In a second step, the trend behaviours of the subtests are analyzed and ranked which illustrates that none of the subtests contained usable trend behaviour thus making an implementation of a PdM system impossible. By using the ranking, the data-driven model is compared with the reliability model which shows that the assumption of the relays being the main error source is inaccurate. An analysis of a possible anomaly detection model for a PdM is evaluated which shows that an anomaly detection is not possible for the test towers as well. The implementability of PdM for test towers and other OMICRON devices is discussed and followed up with proposals for future PdM implementations as well as additional analytical analyses that can be performed for the test towers.
Quantum Sheaf Cohomology, a précis
Creators: name: Guffin, Josh
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 32L10, 81T20

description: We present a brief introduction to quantum sheaf cohomology, a generalization of quantum cohomology based on the physics of the (0,2) nonlinear sigma model.
description: 6 pages, to appear in Proc. Second Latin Congress on Symmetries in Geometry and Physics
title: Der Arbeitsalltag im Homeoffice – Voraussetzungen und Auswirkungen des neuen Arbeitstrends
Creators: name: Lehrmann, Melissa
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2021
Subjects: subject: 300 Sozialwissenschaften

description: Nicht zuletzt seit der Pandemie sind sich Wissenschaftler einig, dass Homeoffice ein fester Bestandteil der Arbeitswelt bleiben wird. Die Coronakrise hat dabei gezeigt, wie wichtig Kompetenzen, wie digitales Know-how und Selbstorganisation, sowie eine offene Unternehmens- und partizipative Führungskultur, für den Erfolg von Homeoffice sind. So soll in der Masterarbeit am Beispiel von Vorarlberg die Forschungsfrage geklärt werden, welche Voraussetzungen für Homeoffice vorliegen müssen und wie sich Homeoffice unter Berücksichtigung soziodemografischer Moderatoren auf Angestellte mit und ohne Führungsverantwortung im Arbeits- und Privatalltag auswirkt. Zur Beantwortung der Forschungsfrage wurden die Erkenntnisse aus Literatur und Forschung mittels einer quantitativen Erhebung in Vorarlberg untersucht. Anhand dieser wird ersichtlich, dass die Rahmenbedingungen in Vorarlberg überwiegend erfüllt werden, aber einzelne, wie die Ergonomie des Heimarbeitsplatzes oder Schulungen im Umgang mit dezentraler Arbeit, noch ausbaufähig sind und Homeoffice selten einzelvertraglich vereinbart wird. Dennoch sind die Angestellten Vorarlbergs insgesamt zufrieden mit Homeoffice und sehen vor allem die Produktivität und Vereinbarkeit von Privat- und Berufsleben positiver als bei der Präsenzarbeit.
description: Not least since the pandemic, scientists have agreed that working from home will remain an integral part of the work environment. The corona crisis has shown how important skills such as digital know-how and self-organization, as well as an open corporate and participatory management culture, are for the success of working from home. In the master's thesis, using the example of Vorarlberg, the research question is to be clarified, which requirements must be met for working from home and how working from home affects employees with and without managerial responsibility in the everyday work and private life, taking into account socio-demographic moderators. To answer the research question, the findings from literature and research were examined by means of a quantitative research in Vorarlberg. The empirical results reveal that the requirements are largely met in Vorarlberg, but some, such as the ergonomics of the home office or training in dealing with decentralized work, are still improvable and that home office is rarely agreed in individual contracts. Nevertheless, the employees in Vorarlberg are overall satisfied with working from home and, above all, see productivity and reconciliation of private and professional life more positively than when working onsite.
Process Evaluation of the Integrated Childsmile Programme. Report of the second tranche of fieldwork (August 2011 to July 2012)
Creators: name: Eaves, Jennifer
name: Williams, Nicola
name: Deas, Leigh
name: Mattu, Leanne
name: Buch Larsen, Helle
name: Gnich, Wendy
Publisher: name: figshare
Year: 2017
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: This report provides findings from the second tranche of the process evaluation of the integrated Childsmile programme, covering the period August 2011 to July 2012.
Childsmile is the national, early years oral health improvement in Scotland. It comprises interacting components (Core: toothbrushing in all nurseries and targeted primary schools, provision of oral health packs at key stages; Nursery & School: fluoride varnishing provided to children in targeted educational establishments; and Practice: support for families with young children to register with and attend dental practices and to engage in protecting their children's oral health).
The purpose of the process evaluation is to explore implementation of the programme, to aid the interpretation of its outcomes.
H-twisted Lie algebroids
Creators: name: Grutzmann, Melchior
Publisher: name: arXiv
Year: 2010
Subjects: subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 17A32, 53D05, 58A50

description: We define a new kind of algebroid which fulfills a Leibniz rule, a Jacobi identity twisted by a 3-form $H$ with values in the kernel of the anchor map, and the twist is closed under a naturally occurring exterior covariant derivative. We give examples and define three kinds of cohomology two via realization as Q-structure on graded manifolds. This classifies PQ3-manifolds.
description: 18 pages, improvements due to the referee, to appear in Journal of Geometry and Physics
title: Clinical low dose photon counting CT for the detection of urolithiasis: Radiation dose reduction is possible without compromising image quality
Creators: name: Kröger, Jan Robert
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Abdomen
subject: Radioprotection / Radiation dose
subject: Urinary Tract / Bladder
subject: CT
subject: Diagnostic procedure
subject: Acute
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Kidney and ureter stones can cause severe symptoms and can lead to hospitalization and renal impairment. Patients suffering from kidney and ureter stones can be of young age with high recurrence rates. Thus, urolithiasis presents a major disease...
Process Evaluation of the Integrated Childsmile Programme. Report of the third tranche of fieldwork (August 2012 to July 2013)
Creators: name: Eaves, Jennifer
name: Williams, Nicola
name: Deas, Leigh
name: Gilmartin, Andrea
name: Buch Larsen, Helle
name: Mackenzie, Sarah
name: Gnich, Wendy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine

description: This report provides findings from the third tranche of the process evaluation of the integrated Childsmile programme, covering the period August 2012 to July 2013.
Childsmile is the national, early years oral health improvement in Scotland. It comprises interacting components (Core: toothbrushing in all nurseries and targeted primary schools, provision of oral health packs at key stages; Nursery & School: fluoride varnishing provided to children in targeted educational establishments; and Practice: support for families with young children to register with and attend dental practices and to engage in protecting their children's oral health).
The purpose of the process evaluation is to explore implementation of the programme, to aid the interpretation of its outcomes.
title: Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸ÐµÐ¼ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾ ÑÑÐ¾Ð»Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Medical table motion control
Creators: name: ÐÑÑÐ¾ÑÐºÐ¸Ð½, ÐÐ¼Ð¸ÑÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: ÐÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¸Ðµ Ð¿ÑÐ¸Ð±Ð¾ÑÑ, Ð°Ð¿Ð¿Ð°ÑÐ°ÑÑ Ð¸ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÑ
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Ð´Ð¸ÑÑÐ°Ð½ÑÐ¸Ð¾Ð½Ð½Ð¾Ðµ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð¸ ÑÐµÐ°Ð»Ð¸Ð·Ð¾Ð²Ð°Ð½Ð° Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸ÐµÐ¼ Ð¼ÐµÑÐ°Ð½ÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐ¾Ð»Ð°. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½ ÐºÑÐ°ÑÐºÐ¸Ð¹ Ð¾Ð±Ð·Ð¾Ñ Ð¼ÐµÑÐ°Ð½ÑÑÐ³Ð¸ÑÐµÑÐºÐ¸Ñ ÑÑÑÐ°Ð½Ð¾Ð²Ð¾Ðº. ÐÐ¿Ð¸ÑÐ°Ð½Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð¼ÐµÑÐ°Ð½ÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐ¾Ð»Ð° Ð¿ÑÐ¸ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¾ÑÐµÐ´ÑÑ. ÐÐ¿Ð¸ÑÐ°Ð½Ð° ÑÐ¸Ð»Ð¾Ð²Ð°Ñ ÑÐ°ÑÑÑ ÑÐ¸ÑÑÐµÐ¼Ñ. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¿Ð¾Ð´ÐºÐ»ÑÑÐµÐ½Ð¸Ðµ ÑÑÑÑÐ¾Ð¹ÑÑÐ² Ð¸ Ð¸Ñ ÐºÐ¾Ð½ÑÐ¸Ð³ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¸ Ð¾Ð¿Ð¸ÑÐ°Ð½Ñ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ñ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¸ ÑÑÑÐ½Ð¾Ð³Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¸Ð½ÑÐµÑÑÐµÐ¹Ñ Ð´Ð»Ñ ÐÐ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Ð½Ð° Ð¾Ð±ÑÐµÐºÑÐµ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ.
description: In this work was developed and implemented an automated motion control system of mechanoreceptor table. A brief overview mechanoelectric installations. Describes the use mechanoreceptor table when casting procedures. The power part of the system is described. The devices are connected and configured. Algorithms of automated and manual control are developed and described. A graphical interface for PC has been developed. The program was tested at the control facility.
title: Limb muscle analysis by magnetic resonance: a quantitative volumetric method
Creators: name: Di Meo, Rosario
Publisher: name: European Congress of Radiology
Year: 2023
Subjects: subject: Artificial Intelligence
subject: Computer applications
subject: Musculoskeletal soft tissue
subject: MR
subject: MR-Functional imaging
subject: Neural networks
subject: Computer Applications-3D
subject: Computer Applications-Virtual imaging
subject: Segmentation
subject: Athletic injuries
subject: Pathology
subject: Tissue characterisation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: In our study, we focus on the creation of a reproducible method for 3D reconstruction and mapping of muscle layers, to lay the foundations for the creation of a reconstruction method that could then be the basis for a future deep learning systems...