title: ÐÐ¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¼Ð°ÑÐºÐµÑÑ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð° Ð»ÐµÐ³ÐºÐ¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Molecular markers of pulmonary tuberculosis activity
Creators: name: ÐÐµÐ¾Ð½ÑÑÐµÐ²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·
ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°
Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ðµ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
tuberculosis
degree of tuberculosis activity
granulomatous inflammation

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð¼Ð°ÑÐºÐµÑÐ¾Ð², ÑÑÐ°ÑÑÐ²ÑÑÑÐ¸Ñ Ð² Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ· ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ Ð»ÐµÐ³ÐºÐ¸Ñ. ÐÐ°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ÑÐ»ÑÐ¶Ð¸Ð»Ð¸ Ð¾Ð±ÑÐ°Ð·ÑÑ ÑÐºÐ°Ð½Ð¸ Ð»ÐµÐ³ÐºÐ¾Ð³Ð¾ Ð»ÑÐ´ÐµÐ¹ Ñ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð¾Ð¼. ÐÐµÑÐ¾Ð´Ð¾Ð¼ Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾ÑÐ¸Ð¼Ð¸Ð¸ Ð±ÑÐ»Ð° Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð°Ñ Ð¿Ð»Ð¾ÑÐ°Ð´Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÐºÐ»Ð°ÑÑÐµÑÐ° Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÐ¾Ð²ÐºÐ¸ CD44, Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð¹ Ð°Ð´Ð³ÐµÐ·Ð¸Ð¸ ICAM-1, ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð³Ð¾ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾ÑÐ° Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð· TIMP-1. Ð¡ Ð¾ÑÐµÐ½ÐºÐ¾Ð¹ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾Ñ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°, ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ Ð¸ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð¸. Ð£ÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ CD44 Ð² Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ðµ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð» ÑÐ°Ð·Ð»Ð¸ÑÐ¸Ñ Ð¿ÑÐ¸ ÑÑÐµÐ¿ÐµÐ½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°, Ð°ÑÑÐ¾ÑÐ¸Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ñ Ð¼Ð¸Ð³ÑÐ°ÑÐ¸ÐµÐ¹ ÐºÐ»ÐµÑÐ¾Ðº. Ð£ÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ICAM-1 Ð² ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÐºÐ°Ð½Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐµ Ð¾ÑÑÐ°Ð¶Ð°ÐµÑ Ð°ÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð²Ð½ÑÐµ Ð¿ÑÐ¾ÑÐµÑÑÑ Ð¸ Ð°ÑÑÐ¾ÑÐ¸Ð¸ÑÐ¾Ð²Ð°Ð½ Ñ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° ÑÐ¸Ð±ÑÐ¾Ð±Ð»Ð°ÑÑÐ¾Ð². TIMP-1 Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÑÐµÑ ÑÐ²ÑÐ·Ñ Ñ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð²Ð½ÑÐ¼Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÐ°Ð¼Ð¸, Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð½Ðµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÐµÑ Ð¿ÑÐµÐ¾Ð±Ð»Ð°Ð´Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð²ÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ Ð¸Ð»Ð¸ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð¸. Ð ÑÐ²ÑÐ·Ð¸ Ñ ÑÑÐ¸Ð¼, ICAM-1 Ð¼Ð¾Ð¶ÐµÑ ÑÐ»ÑÐ¶Ð¸ÑÑ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¼Ð°ÑÐºÐµÑÐ¾Ð¼ ÑÑÐ°Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð¸ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°. CD44 Ð¼Ð¾Ð¶ÐµÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¼Ð°ÑÐºÐµÑÐ° Ð¼Ð¸Ð³ÑÐ°ÑÐ¸Ð¸ ÐºÐ»ÐµÑÐ¾Ðº, Ð² ÑÐ¾ÑÐµÑÐ°Ð½Ð¸Ð¸ Ñ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ð°Ð¼Ð¸, ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÑÑÐ¸Ñ Ð¿ÑÐ» Ð¼Ð¸Ð³ÑÐ¸ÑÑÑÑÐ¸Ñ ÐºÐ»ÐµÑÐ¾Ðº. TIMP-1 Ð¼Ð¾Ð¶ÐµÑ ÑÐ»ÑÐ¶Ð¸ÑÑ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¼Ð°ÑÐºÐµÑÐ¾Ð¼ ÑÐ¾Ð»ÑÐºÐ¾ Ð² ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ð¹ Ð¾ÑÐµÐ½ÐºÐµ Ñ Ð´ÑÑÐ³Ð¸Ð¼Ð¸ Ð¼Ð°ÑÐºÐµÑÐ°Ð¼Ð¸ Ð´Ð»Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°. ÐÐ°ÑÐºÐµÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÑÐµÐ¿ÐµÐ½ÐµÐ¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð»Ñ Ð¾ÑÐµÐ½ÐºÐ¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ñ.
description: The given work is devoted to the analysis of markers expression involved in specific inflammation pathogenesis in pulmonary tuberculosis. Lung tissue samples from people with tuberculosis were used as the material for this study. The relative expression area of the differentiation cluster CD44, cell adhesion molecule ICAM-1, tissue inhibitor of metalloproteinases TIMP-1 were determined by immunohistochemistry. The relationship between the data obtained and the degree of tuberculous process activity, the characteristics of granulomatous inflammation and reparation were evaluated. The expression level of CD44 in the granuloma showed differences in degrees of tuberculous process activity associated with cells migration. The expression level of ICAM-1 in the connective tissue component reflects active reparative processes and is associated with an increase in the number of fibroblasts. TIMP-1 demonstrates a link with reparative processes but does not characterize the prevalence of damage or reparation. Thereby, ICAM-1 can serve as a diagnostic marker of process stabilization and positive dynamics in tuberculosis. CD44 may be used as a diagnostic marker of cells migration in conjunction with molecules that characterize the migrating cells pool. TIMP-1 can serve as a diagnostic marker only in integrated assessment with other markers for the detection of tuberculous process activity. The markers can be used to develop a diagnostic model of tuberculous process activity, and also to evaluate treatment efficacy.