cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
INVESTIGATING ROLES OF THE METABOLIC ENZYME FUMARASE AND THE METABOLITE FUMARATE IN DNA DAMAGE RESPONSE
Creators: name: Saatchi, Faeze
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: In eukaryotic cells, DNA is packaged into a structure named chromatin which contains DNA and proteins. Nucleosomes are building blocks of chromatin and contain DNA wrapped around a histone octamer. Chromatin modifications (histone post-translational modifications and histone variants) play central roles in various cellular processes including gene expression and DNA damage response. Chromatin modifying enzymes use metabolites as co-substrates and co-factors, and changes in metabolic pathways and metabolite availability affects chromatin modifications and chromatin-associated functions. Moreover, recent studies have uncovered direct roles of metabolic enzymes in chromatin-associated functions. Fumarase, a TCA cycle enzyme that catalyzes the reversible conversion of fumarate to malate in mitochondria (a hydration reaction), is an example of an enzyme with dual functions in metabolism and genome integrity. Cytoplasmic fraction of yeast fumarase, Fum1p, localizes to the nucleus and promotes growth upon DNA damage. Fum1p promotes homologous recombination by enhancing DNA end resection. Human fumarase is involved in DNA repair by non-homologous end joining. Here, we provide evidence that yeast Fum1p and the histone variant Htz1p are also involved in DNA replication stress response and DNA repair by non-homologous end joining (NHEJ). Using mutants lacking the histone variant HTZ1, we show that high cellular levels of fumarate, by deletion of FUM1 or addition of exogenous fumarate, suppressed the sensitivity to DNA replication stress by modulation of activity of Jhd2p. This suppression required sensors and mediators of the intra-S phase checkpoint, but not factors involved in the processing of replication intermediates. These results imply that high cellular levels of fumarate can confer resistance to DNA replication stress by bypassing or complementing the defects caused by loss of HTZ1 and replication fork processing factors. We also show that upon induction of DSBs, exogenous fumarate conferred resistance to mutants with defects in NHEJ, early steps of homologous recombination (DNA end resection pathway) or late steps of homologous recombination (strand invasion and exchange). Taken together, these results link the metabolic enzyme fumarase and the metabolite fumarate to DNA damage response and show that modulation of DNA damage response by regulating activity of chromatin modifying enzymes is a plausible pathway linking metabolism and nutrient availability to chromatin-associated functions like genome integrity.
Surveillance of recent HIV infections among newly diagnosed HIV cases in Germany between 2008 and 2014
Creators: name: Hofmann, Alexandra
name: Hauser, Andrea
name: Zimmermann, Ruth
name: Santos-Hövener, Claudia
name: Bätzing-Feigenbaum, Jörg
name: Wildner, Stephan
name: Kücherer, Claudia
name: Bannert, Norbert
name: Hamouda, Osamah
name: Bremer, Viviane
name: Bartmeyer, Barbara
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger; Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: Germany
subject: HIV
subject: Surveillance
subject: Recent HIV infection
subject: Test for recency of infection
subject: Bed-CEIA
subject: 610 Medizin

description: Background: The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely between persons, it is difficult to determine the number of cases of recent HIV infection among newly diagnosed cases of HIV. In Germany, the BED-capture-enzyme immunoassay (BED-CEIA) has been used to distinguish between recent and long-standing HIV infection. The aim of this analysis is to report the proportion of cases of recent HIV infection among newly diagnosed cases in Germany between 2008 and 2014 and to identify factors associated with recent infections. Methods: A sample of voluntary laboratories among all HIV diagnostic laboratories was recruited. Residual blood from HIV diagnostic tests was spotted on filter paper as dried serum or dried plasma spots and was sent along with the notification form of the HIV cases. The BED-CEIA test was performed. A case was defined as recent HIV infection with a BED-CEIA test result of less than 0.8 normalized optical density, with the exclusion of CDC stage C. The proportion of recent newly diagnosed HIV infections among different groups (such as transmission groups, gender or age groups) was calculated. We used logistic regression to identify factors associated with recent HIV infection and to identify subpopulations with high proportions of recent HIV infections. Results: Approximately 10,257 newly diagnosed cases were tested for recency using the BED-CEIA. In total, 3084 (30.4%) of those were recently infected with HIV. The highest proportion of recent HIV infections was found among men who had sex with men (MSM) (35%) and persons between 18 and 25 years of age (43.0%). Logistic regression revealed that female German intravenous drug users with a recent HIV infection had a higher chance of being detected than German MSM (OR 2.27). Conclusions: Surveillance of recent HIV infection is a useful additional tool to monitor the HIV epidemic in Germany. We could observe ongoing HIV transmission in Germany in general and in different subgroups, and we could identify factors associated with recent HIV infection in Germany.
sj-pdf-2-ejo-10.1177_11206721211023320 – Supplemental material for Topical corticosteroids with topical cyclosporine A versus topical corticosteroids alone for immunological corneal graft rejection
Creators: name: Marques, Raquel Esteves
name: Leal, Inês
name: Guerra, Paulo Silva
name: Barão, Rafael Correia
name: Quintas, Ana Miguel
name: Rodrigues, Walter
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-2-ejo-10.1177_11206721211023320 for Topical corticosteroids with topical cyclosporine A versus topical corticosteroids alone for immunological corneal graft rejection by Raquel Esteves Marques, Inês Leal, Paulo Silva Guerra, Rafael Correia Barão, Ana Miguel Quintas and Walter Rodrigues in European Journal of Ophthalmology
A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH
Creators: name: Osman, Mohamed
name: Mistry, Anoop
name: Keding, Ada
name: Gabe, Rhian
name: Cook, Elizabeth
name: Forrester, Sarah
name: Wiggins, Rebecca
name: Marco, Stefania Di
name: Colloca, Stefano
name: Siani, Loredana
name: Cortese, Riccardo
name: Smith, Deborah F.
name: Aebischer, Toni
name: Kaye, Paul M.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: Background: Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin condition that often occurs in patients after successful treatment for VL. Lack of effective or appropriately targeted cell mediated immunity, including CD8+ T cell responses, underlies the progression of VL and progression to PKDL, and can limit the therapeutic efficacy of anti-leishmanial drugs. Hence, in addition to the need for prophylactic vaccines against leishmaniasis, the development of therapeutic vaccines for use alone or in combined immuno-chemotherapy has been identified as an unmet clinical need. Here, we report the first clinical trial of a third-generation leishmaniasis vaccine, developed intentionally to induce Leishmania-specific CD8+ T cells. Methods: We conducted a first-in-human dose escalation Phase I trial in 20 healthy volunteers to assess the safety, tolerability and immunogenicity of a prime-only adenoviral vaccine for human VL and PKDL. ChAd63-KH is a replication defective simian adenovirus expressing a novel synthetic gene (KH) encoding two Leishmania proteins KMP-11 and HASPB. Uniquely, the latter was engineered to reflect repeat domain polymorphisms and arrangements identified from clinical isolates. We monitored innate immune responses by whole blood RNA-Seq and antigen specific CD8+ T cell responses by IFNγ ELISPOT and intracellular flow cytometry. Findings: ChAd63-KH was safe at intramuscular doses of 1x1010 and 7.5x1010 vp. Whole blood transcriptomic profiling indicated that ChAd63-KH induced innate immune responses characterized by an interferon signature and the presence of activated dendritic cells. Broad and quantitatively robust CD8+ T cell responses were induced by vaccination in 100% (20/20) of vaccinated subjects. Conclusion: The results of this study support the further development of ChAd63-KH as a novel third generation vaccine for VL and PKDL.
Additional file 1 of Community-based rehabilitation for people with psychosocial disabilities in low- and middle-income countries: a systematic review of the grey literature
Creators: name: Butura, Ana-Maria
name: Ryan, Grace K.
name: Shakespeare, Tom
name: Ogunmola, Olusegun
name: Omobowale, Olubukola
name: Greenley, Rachel
name: Eaton, Julian
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Science Policy

description: Additional file 1: Categories of the International Classification of Diseases (ICD-10).
Erwerbsarbeit, Familie und Gesundheit bei Männern im erwerbsfähigen Alter in Deutschland
Creators: name: Kroll, Lars Eric
name: Müters, Stephan
name: Rattay, Petra
name: Lampert, Thomas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: Gesundheitsverhalten
subject: Männer
subject: Erwerbsarbeit
subject: Partnerschaft
subject: Elternschaft
subject: Psychische Belastungen
subject: 610 Medizin

description: Hintergrund: Männer wollen sich heute stärker als früher in die Erziehung ihrer Kinder einbringen, sind aber zugleich beruflich stark eingebunden. Der vorliegende Beitrag beschreibt, welche Bedeutung Elternschaft, Partnerschaft und Beruf für die Gesundheit und das Gesundheitsverhalten von Männern im erwerbsfähigen Alter haben. Datenbasis: Für die Analysen werden repräsentative Daten der Studien „Gesundheit in Deutschland aktuell“ (GEDA) für die Jahre 2009, 2010 und 2012 zusammengefasst. Es stehen Daten von 18.465 Männern im Alter von 18 bis 64 Jahren zur Verfügung; 11.429 davon leben mit Kindern im Haushalt. Als Outcomes wurden seelische Belastungen, Gesundheitsbewusstsein, sportliche Aktivität und Rauchen betrachtet. Ergebnisse: Vollzeiterwerbstätige mit einer Wochenarbeitszeit von über 48 Stunden und Arbeitslose sind signifikant häufiger seelisch belastet (Odds Ratio [OR] 1,44 bzw. 2,35; p < 0,05) als Vollzeiterwerbstätige mit Arbeitszeiten von 48 h oder weniger pro Woche; vergleichbare Zusammenhänge zeigen sich auch für das Achten auf die eigene Gesundheit, die sportliche Aktivität und das Rauchverhalten. Für die Partner- und Elternschaft sind die Effekte etwas schwächer: Männer mit Kind/-ern und Partner/-in im Haushalt zeigen sich insgesamt weniger belastet und verhalten sich gesundheitsförderlicher als alleinstehende Männer. Bei gleichzeitiger Betrachtung von Erwerbsstatus, Eltern- und Partnerschaft sind Arbeitslose und Vollzeiterwerbstätige mit langen Arbeitszeiten besonders belastet. Diskussion: Die Ergebnisse geben Hinweise auf gesundheitliche Belastungen von Männern in Deutschland durch Arbeitslosigkeit und überlange Arbeitszeiten, die unabhängig von ihrer Partner- oder Vaterschaft zum Tragen kommen. Die Assoziation der Gesundheit mit der Arbeitswelt ist dabei stärker als die mit der Partner- oder Vaterschaft.
JavaScript Affogato: Programming a Culture of Improvised Expertise
Creators: name: Lennon, Brian
Publisher: name: Humanities Commons
Year: 2018
Subjects: subject: Web site development

description: This essay attempts a philological, meaning a both technically and socially attentive historical study of an individual computer programming language, JavaScript. From its introduction, JavaScript’s reception by software developers, and its importance in web development as we now understand it, was structured by a continuous negotiation of expertise. I use the term “improvised expertise” to describe both conditions for and effects of the unanticipated development of JavaScript, originally designed for casual and inexpert coders, into a complex of technical artifacts and practices whose range and complexity of use has today propelled it into domains previously dominated by other, often older and more prestigious languages. “Improvised expertise” also marks the conditions for and effects of three specific developmental dynamics in JavaScript’s recent history: first, the rapidly accelerated development of the language itself, in the versions of its standard specification; second, the recent, abruptly emerging, yet rapid growth of JavaScript in server-side networking, data processing, and other so-called back end development tasks previously off limits to it; third, the equally recent and abrupt, yet decisive emergence of JavaScript as the dominant language of a new generation of dynamic web application frameworks and the developer toolchains or tooling suites that support them.
Effectiveness of Procedural Agreements in Securities Law
Creators: name: Piterman, Marcel
Publisher: name: Católica Law Review
Year: 2024

description: Investment funds hold important economic and social signif- icance as a savings model that complements state pensions and pen- sion savings plans. The current trend of retail investors gathering to the capital markets is not only attributed to evolving market dynamics; it is also driven by individuals who lack the knowledge and time to thoroughly evaluate all the legal implications of their investments. Consequently, both the total amount of assets invested in funds and the number of individuals participating in investment funds will continue to surge. As a result, the increased participation in investment funds also raises the chances of civil litigation between the involved parties. So, my objective is to evalu- ate this potential development and its management through procedural agreements by studying the effectiveness of procedural agreements in Securities Law.
description: Católica Law Review, v. 8 n. 2 (2024): Católica law review
Additional file 2 of Community-based rehabilitation for people with psychosocial disabilities in low- and middle-income countries: a systematic review of the grey literature
Creators: name: Butura, Ana-Maria
name: Ryan, Grace K.
name: Shakespeare, Tom
name: Ogunmola, Olusegun
name: Omobowale, Olubukola
name: Greenley, Rachel
name: Eaton, Julian
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Science Policy

description: Additional file 2: Search terms.
Supplemental Material, sj-pdf-1-jgp-10.1177_08919887211023592 - A Survey of People With Parkinson’s and Their Carers: The Management of Pain in Parkinson’s
Creators: name: Naisby, Jenni
name: Amjad, Anneesa
name: Ratcliffe, Natasha
name: Yarnall, Alison J.
name: Rochester, Lynn
name: Walker, Richard
name: Baker, Katherine
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental Material, sj-pdf-1-jgp-10.1177_08919887211023592 for A Survey of People With Parkinson’s and Their Carers: The Management of Pain in Parkinson’s by Jenni Naisby, Anneesa Amjad, Natasha Ratcliffe, Alison J. Yarnall, Lynn Rochester, Richard Walker and Katherine Baker in Journal of Geriatric Psychiatry and Neurology
sj-pdf-1-jah-10.1177_08982643211029716 – Supplemental Material for Trends in Dementia Prevalence, Incidence, and Mortality in the United States (2000–2016)
Creators: name: Farina, Mateo P.
name: Zhang, Yuan S.
name: Kim, Jung Ki
name: Hayward, Mark D.
name: Crimmins, Eileen M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-1-jah-10.1177_08982643211029716 for Trends in Dementia Prevalence, Incidence, and Mortality in the United States (2000–2016) by Mateo P. Farina, Yuan S. Zhang, Jung Ki Kim, Mark D. Hayward and Eileen M. Crimmins in Journal of Aging and Health
Programming Support for Scalable, Serializable and Elastic Cloud Applications
Creators: name: Sang, Bo
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Distributed computing and systems software not elsewhere classified
Programming languages

description: Elasticity is an essential feature for cloud applications to handle varying and unpredictable workloads in a cost-effective way on cloud platforms. However, implementing a stateful elastic application is hard, as programmers have to: (1) reason about concurrent execution in the applications (serializability); (2) guarantee the application can process more requests with larger scale (scalability); and (3) provide elasticity management to improve performance and resource efficiency for applications (efficient elasticity management). Unfortunately, addressing all those concerns requires deep understanding and rich experience in distributed systems and cloud computing. In this dissertation, we provide programming support to help programmers implement their stateful elastic cloud applications in a simpler manner. Specifically, we present AEON, an actor-based programming language, and \arch, an elastic programming framework. On the one hand, AEON provides programmers with scalability and serialzability, executing actor-based programs in a serialized manner while still retaining a high degree of parallelism. Meanwhile, AEON can adjust programs' scale via fine-grained live actor migration. On the other hand, PLASMA includes (1) an elastic programming language as a second ``level'' of programming (complementing the main application programming language) for describing elasticity behaviors, and (2) a novel semantics-aware elasticity management runtime that tracks program execution and acts upon application features as suggested by elasticity behaviors. With these, PLASMA can provide efficient elasticity management to cloud applications
Protracted outbreak of S. Enteritidis PT 21c in a large Hamburg nursing home
Creators: name: Frank, Christina
name: Buchholz, Udo
name: Maaß, Monika
name: Schröder, Arthur
name: Bracht, Karl- Hans
name: Domke, Paul-Gerhard
name: Rabsch, Wolfgang
name: Fell, Gerhard
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger; Robert Koch-Institut, Infektionsepidemiologie
Year: 2007
Subjects: subject: Aged
subject: Humans
subject: Disease Outbreaks
subject: Gastroenteritis/epidemiology
subject: Germany/epidemiology
subject: Homes for the Aged
subject: Nursing Homes
subject: Salmonella Food Poisoning/epidemiology
subject: Salmonella enteritidis/classification
subject: Salmonella enteritidis/isolation & purification
subject: Salmonella enteritidis/pathogenicity
subject: 610 Medizin

description: Background: During August 2006, a protracted outbreak of Salmonella (S.) Enteritidis infections in a large Hamburg nursing home was investigated. Methods: A site visit of the home was conducted and food suppliers' premises tested for Salmonella. Among nursing home residents a cohort study was carried out focusing on foods consumed in the three days before the first part of the outbreak. Instead of relying on residents' memory, data from the home's patient food ordering system was used as exposure data. S. Enteritidis isolates from patients and suspected food vehicles were phage typed and compared. Results: Within a population of 822 nursing home residents, 94 case patients among residents (1 fatality) and 17 among staff members were counted 6 through 29 August. The outbreak peaked 7 through 9 August, two days after a spell of very warm summer weather. S. Enteritidis was consistently recovered from patients' stools throughout the outbreak. Among the food items served during 5 through 7 August, the cohort study pointed to afternoon cake on all three days as potential risk factors for disease. Investigation of the bakery supplying the cake yielded S. Enteritidis from cakes sampled 31 August. Comparison of the isolates by phage typing demonstrated both isolates from patients and the cake to be the exceedingly rare phage type 21c. Conclusion: Cake (various types served on various days) contaminated with S. Enteritidis were the likely vehicle of the outbreak in the nursing home. While the cakes were probably contaminated with low pathogen dose throughout the outbreak period, high ambient summer temperatures and failure to keep the cake refrigerated led to high pathogen dose in cake on some days and in some of the housing units. This would explain the initial peak of cases, but also the drawn out nature of the outbreak with cases until the end of August. Suggestions are made to nursing homes, aiding in outbreak prevention. Early outbreak detection is crucial, such that counter measures can be swift and drawn-out outbreaks of nosocomial food-borne infections avoided.
title: A Vision for Peace and Stability in North-East India: An Integrative Approach Anchored in Cultural Understanding and Constructive Communication
title: A Path to Harmony in Northeast India
titleType: Subtitle
Creators: name: Kallol, Chakrabarti
Publisher: name: Zenodo
Year: 2024

description:     The North-Eastern region of India, particularly states such as Manipur, has historically been characterized by insurgency, ethnic conflict, and socio-political instability. Establishing a framework for enduring peace necessitates addressing the underlying causes of these challenges. This document presents a comprehensive strategy aimed at mitigating violence, insurgency, and detrimental narratives through the promotion of cultural education, community engagement, and effective communication. Key initiatives include the eradication of narcotic cultivation, the dissemination of constructive rhetoric via social media, and the integration of the philosophies presented in the Bhagavad Gita within local and tribal communities.
Neutron Spectroscopy Development in Tensioned Metastable Fluid Detectors
Creators: name: Sansone, Anthony A.
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Nuclear engineering (incl. fuel enrichment and waste processing and storage)

description: This dissertation describes work conducted in pursuit of interests in adapting Tension Metastable Fluid Detectors (TMFDs) for dosimetry-related applications with the specific intent of engineering a neutron ambient dose spectrometer. TMFDs possess several charac- teristics desirable for neutron spectrometry, including high efficiencies, complete blindness to gamma and beta radiation, and tailorable-threshold response functions. Prior spectro- scopic work with TMFDs, aptly named Single Atom Spectroscopy (SAS), was constrained to a specific subset of detection fluids who’s composition includes hydrogen and only one other higher Z element (e.g. hydrocarbons), where only one element is assumed capable of initiating a cavitation detection event (CDE). The present work alleviates these restrictions, enabling spectroscopy in detection fluids with multiple constituent elements. Simulating the detector’s response predicates knowledge of the energy necessary for ra- diation induced nucleation, which has been theoretically derived with nucleation theory for superheated fluids, but remains unbeknownst for tensioned metastable states. This limi- tation was overcome using MCNPX-PoliMI to model the spatial recoil nuclei spectra from isotope sources and coupled with SRIM to generate the ion energy deposition probabil- ity density within a critical length scale of each interaction event. Thereafter, the energy deposition threshold necessary to generate a detection event, and corresponding response matrix, was derived empirically by solving for the solution curve that minimizes the residual difference between the measured and simulated count rates. The accuracy of the derived response matrix was evaluated through comparisons with a 6LiI Bonner Sphere Spectrometer in which, for 252Cf and 239PuBe/241AmBe isotope source neutron spectra, the two systems offered results within ±10% of each other for ambient equivalent fluences on the order of 100 μRem/hr fields. Notably, when under ultra-low (10 μRem/hr) fields the Bonner spectrometer and other traditional detectors proved impractical. In contrast, the TMFD system was capable of resolving underlying spectral features and corresponding ambient dose rates within ±5% of MCNP predictions.
Additional file 3 of Community-based rehabilitation for people with psychosocial disabilities in low- and middle-income countries: a systematic review of the grey literature
Creators: name: Butura, Ana-Maria
name: Ryan, Grace K.
name: Shakespeare, Tom
name: Ogunmola, Olusegun
name: Omobowale, Olubukola
name: Greenley, Rachel
name: Eaton, Julian
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Science Policy

description: Additional file 3: Data extraction table; summary of results.
Identifying outbreaks of sexually transmitted infection: who cares?
Creators: name: Werber, Dirk
name: Evans, Meirion R
name: Thomas, Daniel Rh
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2006
Subjects: subject: Humans
subject: Population Surveillance
subject: Clinical Competence
subject: Communicable Disease Control/standards
subject: Cross-Sectional Studies
subject: Disease Outbreaks*/prevention & control
subject: Health Personnel/psychology
subject: Health Personnel/standards
subject: Health Personnel/statistics & numerical data
subject: Patient Care Team
subject: Public Health Administration/standards
subject: Questionnaires
subject: Sexually Transmitted Diseases/prevention & control
subject: Sexually Transmitted Diseases/psychology
subject: Specialties
subject: Medical/statistics & numerical data
subject: Wales/epidemiology
subject: 610 Medizin

description: Background: Current routine surveillance schemes for sexually transmitted infections (STIs) in the United Kingdom (UK) are not designed for outbreak identification. Recognising STI outbreaks, therefore, depends almost entirely on the alertness of health professionals. The objective of this study was to explore health professionals' knowledge of, and attitudes towards, identification and investigation of STI outbreaks in Wales. Methods: We conducted a cross-sectional survey in Wales in June 2005, and sent a questionnaire to consultants of genitourinary medicine (GUM, n = 11), a consultant microbiologist from each laboratory (n = 14), all consultants in communicable disease control (n = 5), and to epidemiologists of the National Public Health Service (n = 4). Results: 26 (76%) of 34 survey recipients responded. Of these, 17 (65%) ranked the investigation of STI outbreaks as important or very important, and 19 (73%) perceived participation in the investigation of an STI outbreak as part of their responsibility. Only six (25%) respondents had actively searched their computer system or patient records for a possible STI outbreak in the previous twelve months, and 15 (63%) had never looked for an outbreak. Of seven GUM physicians who said they had identified at least one STI outbreak, three had never informed public health authorities. Conclusion: Prompt identification and coordinated investigation of outbreaks, usually through a multidisciplinary outbreak control team, is central to the control of many infectious diseases. This does not appear to be the case for STIs, which we believe represents a lost opportunity to reduce transmission. Besides improved surveillance methods, a change in culture towards STI outbreaks is needed among health professionals in Wales.
Gender and Politics in the Henrician Court: The Douglas-Howard Lyrics in the Devonshire Manuscript (BL Add 17492)
Creators: name: Irish, Bradley
Publisher: name: Humanities Commons
Year: 2011
Subjects: subject: European poetry--Renaissance
subject: Manuscripts
subject: Women authors
subject: Literature
subject: Sixteenth century

description: BL Additional MS 17492, the so-called Devonshire Manuscript of Henrician courtly verse, is a prime example of how social and cultural phenomena contributed to early modern manuscript culture. Among the treasures of the Devonshire MS is a series of lyrics that chronicles a fascinating courtly intrigue of the 1530s: the illicit, clandestine marriage of Lord Thomas Howard and Lady Margaret Douglas, the headstrong niece of Henry VIII. After unpacking this historical drama, this essay advances the first substantial literary analysis of these poems by exploring the textual strategies through which Howard and Douglas attempted to negotiate the crown’s insistent management of their erotic life. This treatment of the Douglas-Howard lyrics provides new opportunity to consider how the Devonshire MS reflects and refracts the gender dynamics of the contemporary Henrician court.
Oseltamivir-Resistant Influenza Virus A (H1N1), Europe, 2007–08 Season
Creators: name: Meijer, Adam
name: Lackenby, Angie
name: Hungnes, Olav
name: Lina, Bruno
name: Werf, Sylvie Van Der
name: Schweiger, Brunhilde
name: Opp, Matthias
name: Paget, John
name: Kassteele, Jan Van De
name: Hay, Alan
name: Zambon, Maria
name: Buchholz, Udo
name: Haas, Walter
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: Human/epidemiology
subject: Viral
subject: Humans
subject: Genes
subject: Phylogeny
subject: Population Surveillance/methods
subject: Mutation
subject: Antiviral Agents/pharmacology
subject: Communicable Diseases
subject: Emerging/drug therapy
subject: Emerging/epidemiology
subject: Emerging/virology
subject: Drug Resistance
subject: Viral/genetics
subject: Enzyme Inhibitors/pharmacology Europe/epidemiology
subject: Hemagglutinins
subject: Influenza A Virus
subject: H1N1 Subtype/classification
subject: H1N1 Subtype/drug effects
subject: H1N1 Subtype/enzymology
subject: H1N1 Subtype/genetics
subject: Influenza
subject: Human/drug therapy
subject: Human/virology
subject: Neuraminidase/antagonists & inhibitors
subject: Neuraminidase/genetics
subject: Oseltamivir/pharmacology
subject: Seasons
subject: 610 Medizin

description: In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.
Sleep and Dream-States in Literature, Science, and Medicine, 1700-1899
Creators: name: Schatz, Stephanie L.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aesthetics
Art history, theory and criticism not elsewhere classified
Historical studies not elsewhere classified
History and philosophy of science
British history
British and Irish literature

description: The purpose of this study has been to contribute to the emerging interdisciplinary field of historical sleep studies, which spans the biological and social sciences, legal studies, and the humanities. As an interdisciplinary scholar based primarily in the humanities, my goals have been twofold: to develop a critical archive for the use of scholars in this emerging field; and to demonstrate how that archive might be used to productive effect in literary studies. To that end, this project begins with a critical introduction to the field of sleep studies and its relationship to eighteenth- and nineteenth-century thought and follows with two distinct but connected sections: the archive itself and a short series of literary case-studies drawn from across the eighteenth and nineteenth centuries. My hope is that these case studies will show how the materials in the archive allow literary scholars to produce new insights about familiar, canonical texts.
Additional file 4 of Community-based rehabilitation for people with psychosocial disabilities in low- and middle-income countries: a systematic review of the grey literature
Creators: name: Butura, Ana-Maria
name: Ryan, Grace K.
name: Shakespeare, Tom
name: Ogunmola, Olusegun
name: Omobowale, Olubukola
name: Greenley, Rachel
name: Eaton, Julian
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Science Policy

description: Additional file 4: Quality assessment scoring and Inter-rater score.
Additional file 5 of Community-based rehabilitation for people with psychosocial disabilities in low- and middle-income countries: a systematic review of the grey literature
Creators: name: Butura, Ana-Maria
name: Ryan, Grace K.
name: Shakespeare, Tom
name: Ogunmola, Olusegun
name: Omobowale, Olubukola
name: Greenley, Rachel
name: Eaton, Julian
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Science Policy

description: Additional file 5: Additional extraction: Reported challenges to implementation.
Quantitative Prediction of Non-Local Material and Transport Properties Through Quantum Scattering Models
Creators: name: Sarangapani, Prasad
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Nanomaterials
Nanoelectronics
Foundations of quantum mechanics
Quantum physics not elsewhere classified
Elemental semiconductors

description: Challenges in the semiconductor industry have resulted in the discovery of a plethora of promising materials and devices such as the III-Vs (InGaAs, GaSb, GaN/InGaN) and 2D materials (Transition-metal dichalcogenides [TMDs]) with wide-ranging applications from logic devices, optoelectronics to biomedical devices. Performance of these devices suffer significantly from scattering processes such as polar-optical phonons (POP), charged impurities and remote phonon scattering. These scattering mechanisms are long-ranged, and a quantitative description of such devices require non-local scattering calculations that are computationally expensive. Though there have been extensive studies on coherent transport in these materials, simulations are scarce with scattering and virtually non-existent with non-local scattering. In this work, these scattering mechanisms with full non-locality are treated rigorously within the Non-Equilibrium Green's function (NEGF) formalism. Impact of non-locality on charge transport is assessed for GaSb/InAs nanowire TFETs highlighting the underestimation of scattering with local approximations. Phonon, impurity scattering, and structural disorders lead to exponentially decaying density of states known as Urbach tails/band tails. Impact of such scattering mechanisms on the band tail is studied in detail for several bulk and confined III-V devices (GaAs, InAs, GaSb and GaN) showing good agreement with existing experimental data. A systematic study of the dependence of Urbach tails with dielectric environment (oxides, charged impurities) is performed for single and multilayered 2D TMDs (MoS2, WS2 and WSe2) providing guideline values for researchers.
Often, empirical local approximations (ELA) are used in the literature to capture these non-local scattering processes. A comparison against ELA highlight the need for non-local scattering. A physics-based local approximation model is developed that captures the essential physics and is computationally feasible.
Analysis of collection of hemolytic uremic syndrome-associated enterohemorrhagic Escherichia coli.
Creators: name: Mellmann, Alexander
name: Bielaszewska, Martina
name: Köck, Robin
name: Friedrich, Alexander W.
name: Fruth, Angelika
name: Middendorf, Barbara
name: Harmsen, Dag
name: Schmidt, M. Alexander
name: Karch, Helge
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2008
Subjects: subject: Humans
subject: Phylogeny
subject: Enterohemorrhagic Escherichia coli/classification
subject: Enterohemorrhagic Escherichia coli/genetics*
subject: Enterohemorrhagic Escherichia coli/isolation & purification
subject: Hemolytic-Uremic Syndrome/microbiology
subject: 610 Medizin

description: Multilocus sequence typing of 169 non-O157 enterohemorrhagic Escherichia coli (EHEC) isolated from patients with hemolytic uremic syndrome (HUS) demonstrated 29 different sequence types (STs); 78.1% of these strains clustered in 5 STs. From all STs and serotypes identified, we established a reference panel of EHEC associated with HUS (HUSEC collection).
Inspection of Steel Bridge Welds Using Phased Array Ultrasonic Testing
Creators: name: Schroeder, Curtis J.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Structural engineering

description: The objective of this research is to develop recommendations on calibration standards, scanning procedures, and acceptance criteria for phased array ultrasonic testing (PAUT) of complete joint penetration butt welds within the AWS D1.5 Bridge Welding Code. These recommendations include the development of a rational acceptance criteria which is based in engineering analysis and fracture mechanics. It is expected that the updated scanning procedures and acceptance criteria will result in improved reliability for bridges and improved consistency in bridge fabrication quality.
 While PAUT was included in the 2015 edition of AWS D1.5 in Annex K, the acceptance criteria for this procedure was developed as an adaptation of an existing conventional ultrasonic testing (UT) acceptance criteria in AWS D1.1. Therefore, the acceptance criteria in AWS D1.5:2015 is a workmanship-based criteria and is not based on engineering analysis of the criticality of weld flaws. The scanning procedures and application of PAUT inspections of bridge welds according to this procedure differ greatly from the scanning procedures outlined in AWS D1.5 for conventional UT inspections. Previous research has shown that differences in flaw rejection are possible for PAUT and conventional UT ultrasonic methods under the AWS D1.5:2015 approach.
 In order to develop recommendations for improved calibration standards, scanning procedures, and acceptance criteria for PAUT within AWS D1.5, this research project utilized both analytical techniques and experimental testing. This research project included determination of target critical flaw sizes for routine detection and rejection through fitness-for-service evaluations. This was followed by a round robin ultrasonic testing program in order to collect data on the variability of inspection results of eleven weld samples with nineteen weld flaws using different ultrasonic inspection techniques. Next, calibration requirements were developed to account for differences in ultrasonic attenuation and shear wave velocity between calibration blocks and test objects. Development of these requirements included experimental testing of base metals and weld metals, along with simulations of ultrasonic inspection using commercial software. Finally, minimum requirements for weld scanning procedures, reference standard reflectors, and corresponding amplitude limits for detection and rejection of target critical weld flaws were developed using ultrasonic inspection simulations and verified through experimental testing of weld samples with known weld flaws.
sj-pdf-1-aas-10.1177_00953997211025983 – Supplemental material for The Effectiveness of Monetary and Promotion Rewards in the Public Sector and the Moderating Effect of PSM (PSM-Reward Fit or PSM Crowding Out): A Survey Experiment
Creators: name: Ki, Namhoon
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-pdf-1-aas-10.1177_00953997211025983 for The Effectiveness of Monetary and Promotion Rewards in the Public Sector and the Moderating Effect of PSM (PSM-Reward Fit or PSM Crowding Out): A Survey Experiment by Namhoon Ki in Administration & Society
sj-docx-1-vaw-10.1177_10778012211021108 – Supplemental material for Correlates of Safety Strategy Use Among South African Women Living With HIV and at Risk of Intimate Partner Violence
Creators: name: Brown, Leslie Lauren
name: Perkins, Jessica Mayson
name: Hargrove, Jami Lynn
name: Pahl, Kathryn Elenor
name: Mogoba, Phepo
name: van Zyl, Michiel Adriaan
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, sj-docx-1-vaw-10.1177_10778012211021108 for Correlates of Safety Strategy Use Among South African Women Living With HIV and at Risk of Intimate Partner Violence by Leslie Lauren Brown, Jessica Mayson Perkins, Jami Lynn Hargrove, Kathryn Elenor Pahl, Phepo Mogoba and Michiel Adriaan van Zyl in Violence Against Women
Additional file 1 of Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Creators: name: Kim, Eun-Young
name: Kim, Ji-Eun
name: Kim, Young-Eun
name: Choi, Bongkun
name: Sohn, Dong Hyun
name: Park, Si-On
name: Chung, Yeon-Ho
name: Kim, Yongsub
name: Robinson, William H.
name: Kim, Yong-Gil
name: Chang, Eun-Ju
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Cancer

description: Additional file 1: Figure S1. Parkin expression in mOCs was colocalized with tubulin but not actin. mOCs from WT mice grown on glass coverslips were stained with phalloidin probe (for F-actin; red), Cy™3-conjugated antibodies (for β-tubulin; yellow), or/and FITC-conjugated antibodies (for parkin; green), counterstained for nuclei (DAPI, blue), and observed by confocal microscopy. Figure S2. Inflammatory cytokines reduce parkin expression. (A, B) BMMs (A) andRANKL-primed OCs (B) were treated with inflammatory cytokines, such as TNF-α (10 ng/ml) or IL-1β (10 ng/ml) for 48 h, and parkin protein expression was analyzed by western blot analysis. Densitometric quantification of parkin was compared to β-actin using ImageJ software. Data are represented as means ± SD. *P < 0.005, **P < 0.005, and ***P < 0.001 vs. buffer control. Figure S3. Depletion of parkin enhances IL-1β-induced OC activity. (A–C) Depletion of parkin does not affect differentiation but increases OC activity. BMMs from WT or Parkin-/- mice in osteoclastogenic media were treated with IL-1β, fixed, and TRAP-stained. The (A) numbers of TRAP+ MNCs (≥ 3 nuclei), (B) TRAP+ MNCs with actin rings, and (C) the area of TRAP+ MNCs werequantified under a light microscope. Data are the mean ± SD; *P < 0.05, **P < 0.005, and ***P < 0.001 between the indicated groups. P-values were calculated by Tukey’s test for multiple comparisons. Table S1. Primer information for cloning of parkin-deletion mutants.
Der telefonische Gesundheitssurvey 2003 als Instrument der Gesundheitsberichterstattung des Bundes
Creators: name: Ziese, Thomas
name: Neuhauser, Hannelore
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2005
Subjects: subject: Gesundheitssurveys
subject: Gesundheitsziele
subject: CATI
subject: Gesundheitsdaten
subject: Monitoring
subject: Health targets
subject: Health monitoring
subject: Health surveys
subject: Health data
subject: 610 Medizin

description: Im Robert Koch-Institut werden Gesundheitssurveys bereits seit den 1980er-Jahren in unregelmäßigen Abständen durchgeführt. Telefonsurveys werden international seit einiger Zeit als Ergänzung zu den Untersuchungs- und Befragungssurveys eingesetzt. Diese kostengünstige und schnelle Art der Datengewinnung ermöglicht es zum einen, Zeitreihen zur Gesundheit weiterzuführen, und zum anderen, gleichzeitig auf aktuelle gesundheitsrelevante Fragestellungen reagieren zu können, unter anderem auch deshalb bilden die telefonischen Gesundheitssurveys einen wichtigen Baustein für das aufzubauende Gesundheitsmonitoringsystem in Deutschland. Von September 2002–März 2003 wurden erstmals 8313 Personen aus der deutschsprachigen Wohnbevölkerung ab 18 Jahren u. a. zu Krankheiten, zu ihrem Gesundheitsverhalten und zur Inanspruchnahme von Leistungen des Gesundheitswesens befragt.
description: The Robert Koch Institute has carried out health surveys at irregular intervals since the 1980s . Internationally telephone surveys have been used to supplement examination surveys for some time. Health interview surveys by telephone provide a timely and inexpensive possibility to build up a time series on health while being flexible enough to cover new health aspects. Health telephone surveys will also serve as a module of a coming health-monitoring system in Germany, which is currently under discussion. From September 2002 to March 2003, 8,313 German-speaking people randomly selected from the resident population aged 18 years and over were asked about topics such as chronic diseases, health behaviour and the extent to which they make use of health care services and others.
Alkoholkonsum unter Berliner Schülern
Creators: name: Heß, Heike
name: Richter, Matthias
name: Dortschy, Reinhard
name: Kahl, Heidrun
name: Tietze, Konrad
name: Hüther, Hans
name: Röseler, G.
Publisher: name: Robert Koch-Institut
Year: 1998
Subjects: subject: 610 Medizin

description: Der Alkoholkonsum Berliner Schüler der siebten bis zehnten Klassen, untersucht an Haupt- und Gymnasialschülern, hat sich in den vergangenen zehn Jahren verändert: Der Anteil Abstinenter ist insgesamt gestiegen, die Häufigkeit und Menge des getrunkenen Alkohols sind leicht zurückgegangen. Doch ist der Gesamtverbrauch an Alkohol unter den von uns untersuchten Schülern der siebten bis zehnten Klassen um 32% gestiegen. Dies ist vor allem von den Vieltrinkern verursacht; es gibt einen Anteil von etwa 6% der Schüler, die täglich trinken und damit in Gefahr sind, eine Alkoholikerkarriere zu beginnen. Die wichtigsten Korrelate des Trinkens sind der eigene Spaß am Trinken und ein Freundeskreis, der am Trinken Gefallen findet. Schüler in Ostberlin sind stärker gefährdet als solche in Westberlin, Mädchen weniger als Jungen. Die Trinkmenge steigt mit dem Altersgang rasch an.
description: The alcohol consumption among Berlin school children from the 7th to 10th class investigated in school children of primary and secondary schools has changed during the past ten years: altogether, the number of school children refraining from alcohol has increased, the frequency and the amount of alcohol consumed have slightly diminished. However, the total consumption of alcohol among school children from the 7th to 10th class investigated has increased by 32%. This has to be attributed mainly to those who drink considerable quantities; about 6% of the school children drink daily and thus are endangered to start a career as an alcoholic. The most important factors corelated with drinking are the own joy in drinking and friends who take pleasure in drinking. School children in East Berlin are more endangered than those in West Berlin and girls less than boys. The amount consumed increases rapidly with advancing age.