COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
Creators: name: Carrabba, Maria
name: Lima, Fabiana Mascarenhas Souza
name: Giardino, Giuliana
name: Martone, Giulia M.
name: Pignata, Claudio
name: Jeong, Stephanie
name: Tarquini, Lucia
name: Jordan, Michael B.
name: Magnusson, Julieann
name: Vergadi, Eleni
name: Alsaati, Nouf
name: Ariue, Barbara
name: Fernandez, James M.
name: Consonni, Filippo
name: Hammarström, Lennart
name: Bergerson, Jenna R. E.
name: Mustillo, Peter J.
name: Naviglio, Samuele
name: Tang, Monica
name: Raje, Nikita
name: Risma, Kimberly A.
name: Doss, Alexa Michelle Altman
name: Arnold, Danielle E.
name: Chandra, Sharat
name: Tam, Jonathan S.
name: Cabanillas, Diana
name: Ortega-López, María Claudia
name: Leiding, Jennifer W.
name: Lim, Xin Rong
name: Boesing, John
name: Brodszki, Nicholas
name: Niebur, Hana B.
name: Mechtler, Annamaria G.
name: Demirdag, Yesim Yilmaz
name: Diaz-Cabrera, Natalie M.
name: Chapdelaine, Hugo
name: Geerlinks, Ashley V.
name: Grecco, Octavio
name: Kokron, Cristina M.
name: Salemi, Negin
name: Kalkat, Amanpreet
name: Catanzaro, Jason R.
name: Wang, Christine
name: Milner, Joshua D.
name: Notarangelo, Luigi
name: Khoury, Ruby
name: Chong, Hey Jin
name: Khani, Hedieh Haji Khodaverdi
name: Sullivan, Kathleen E.
name: Schuval, Susan J.
name: Hsiao, Kuang-Chih
name: Galant-Swafford, Jessica
name: Signa, Sara
name: Wu, Eveline Y.
name: Zhou, Jessie J.
name: Verbsky, James
name: Callahan, Meghan A.
name: Prince, Benjamin T.
name: McDonnell, John
name: Abolhassani, Hassan
name: Carbone, Javier
name: Petrovic, Gordana
name: Fill, Lauren
name: Franco, Guacira R.
name: Abraham, Roshini S.
name: Cousins, Kimberley
name: ElGhazali, Gehad
name: Fabio, Giovanna
name: Jaber, Faris
name: Jamee, Mahnaz
name: Aytekin, Caner
name: Heimall, Jennifer
name: Seneviratne, Suranjith L.
name: Sherkat, Roya
name: Cunningham-Rundles, Charlotte
name: Qamar, Nashmia
name: Al-Faris, Eman Hesham
name: Wall, Luke A.
name: Routes, John
name: Marseglia, Gian Luigi
name: Horner, Caroline C.
name: Kellner, Erinn S.
name: Hristova, Nataliya
name: Siddiqi, Abeer
name: Jean, Tiffany
name: López, Ana Laura
name: Lundgren, Ingrid S.
name: Alfaro-Murillo, Alberto
name: Feng, Jin
name: Connors, Lori
name: Regairaz, Lorena
name: Rabusin, Marco
name: AlKhater, Suzan A.
name: Castagnoli, Riccardo
name: Angarola, Ernestina
name: Chan, Samantha
name: Stenehjem, Kristen K.
name: Garabedian, Elizabeth K.
name: Khojah, Amer
name: Porras, Oscar
name: Jhaveri, Devi
name: Marinho, Ana Karolina B. B.
name: Joshi, Avni Y.
name: Voelker, Dayne H.
name: Anderson, Melissa
name: Lehman, Heather K.
name: Lesmana, Harry
name: Bleesing, Jack
name: Hartog, Nicholas L.
name: Naderi, Asal Gharib
name: Bouso, Carolina
name: Nell, Jeremy
name: Ristagno, Elizabeth H.
name: Barros, Myrthes Toledo
name: Assa’ad, Amal H.
name: Delmonte, Ottavia Maria
name: Caorsi, Roberta
name: Deshpande, Deepti R.
name: Lopes, Joao Pedro
name: Mendonca, Leonardo
name: Dimitriades, Victoria R.
name: Chavoshzadeh, Zahra
name: Goudouris, Ekaterini
name: Cook, Alexandria
name: Pan-Hammarström, Qiang
name: Kumar, Ashish
name: Scalchunes, Christopher
name: Lecerf, Kelsey
name: Williams, Kelli W.
name: Wu, Shan Shan
name: Cady, Carol
name: Oleastro, Matias
name: Patel, Neil R.
name: El-Owaidy, Rasha
name: Al-Hammadi, Suleiman
name: Marsh, Rebecca
name: Ivankovich-Escoto, Gabriela
name: Gambineri, Eleonora
name: Jalil, Maaz
name: Fuleihan, Ramsay L.
name: Sobh, Ali
name: Correa-Jimenez, Oscar
name: Puck, Jennifer M.
name: Younger, M. Elizabeth M.
name: Al-Tamemi, Salem
name: Volpi, Stefano
name: Frenck, Robert W.
name: Lane, Adam
name: Aldave-Becerra, Juan Carlos
name: Faure, Astrid Schellnast
name: Bank, Meaghan
name: Hernandez-Molina, Gabriela
name: Kanarek, Henry J.
name: Hostoffer, Robert W.
name: Shankar, Ashwin
name: D’Astous-Gauthier, Katherine
name: Shin, Junghee Jenny
name: Roxo-Junior, Persio
Publisher: name: Springer Nature
Year: 2024

description: Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.