cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterisation of the 1B4 antigen.
Creators: name: Luus, Lia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Molecular.

description: Processes occurring within the nucleus are thought to be organised by a matrix of protein and RNA. The individual protein components of this structure are not well defined. This work describes the characterisation of an antigen identified by the 1B4 antibody, which was created as part of an effort to identify novel nuclear proteins. This antibody was raised against a nuclear matrix extract of HL-60 cells to specifically target proteins which are components of, or associated with, the nonchromatin structure of the nucleus. It detects a 100 kDa protein in mitotic HeLa cells. I have performed experiments to verify that this antigen is a nuclear matrix protein in which I extracted cells in situ and detected the 1B4 antigen by immunofluorescence. Further experiments involved immunofluorescence studies in which I compared the distribution of the 1B4 antigen to distributions of proteins with known functions related to pre-mRNA splicing. (Abstract shortened by UMI.)
How are school counselors implementing school-based career counseling interventions within the context of COVID-19? A qualitative inquiry
Creators: name: Smith, Enrique
Publisher: name: University of Iowa
Year: 2023
Subjects: Career Counseling
COVID
middle school
public abstract

description: In the year of 2020, COVID-19 disrupted the provision of face-to-face school interventions, namely career interventions, across the United States. This is problematic as school-based career interventions have been found to: increase interest in future careers through course preparation, increase academic achievement, and increase the possibility of students graduating and going on to post-secondary settings (Albritton et al., 2018; Stipanovic et al., 2017; Sanders et al., 2017) Moreover, middle schools in Iowa are mandated to provide career development and exploration curriculum to students (American School Counselor Association). Given this disruption to services, especially in regards to school-based career interventions in Iowa, this qualitative study aimed to examine how school counselors in Iowa Middle schools responded and worked to adapt career curriculum in the context of COVID-19, as well as what barriers hindered them and how effective these efforts were. Specifically, this study conducted semi-structured interviews with eight middle school counselors in Iowa. Data was analyzed using Consensual Qualitative Research (CQR; Hill et al., 2005). Results from this study showed domains related to social emotional factors, structural impact on schooling, resiliency, interest shifts, and hopes for the future.
3646167.pdf
Creators: name: Magrini, Lorenzo
name: Norte, Richard
name: Riedinger, Ralf
name: Marinković, Igor
name: Grass, David
name: Delić, Uroš
name: Gröblacher, Simon
name: Hong, Sungkun
name: Aspelmeyer, Markus
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document that contains additional information about the detailed experimental procedures and relevant theoretical background of the works presented in the main manuscript
The SSRMI scale : development and validation of a self-stigma measure for first-degree relatives of people with mental illness
Creators: name: Morris, E.
name: Hippman, C.
name: Murray, G.
name: Michalak, Erin E.
name: Boyd, J.E.
name: Livingston, J.
name: Inglis, A.
name: Carrion, P.
name: Austin, J.
Publisher: name: The University of British Columbia
Year: 2019

description: Background: Serious mental illnesses (SMIs) are profoundly stigmatized, such that even relatives of people with SMI are impacted. Aims: To develop/validate a scale to comprehensively measure self-stigma among first-degree relatives of individuals with SMI. Methods: We conducted group interviews focusing on self-stigma with first-degree relatives (n=20) of people with SMI, from which 74 representative quotations were reframed as Likert-type items. Cognitive interviews with relatives (n=11) identified 30 items for the Self-Stigma in Relatives of people with Mental Illness (SSRMI) scale. Relatives (n=195) completed the scale twice, a month apart, together with four external correlate scales. Results: The 30-item SSRMI was reliable, with scores stable over time. Its single factor structure allowed generation of a 10-item version. Construct validity of 30- and 10-item versions was supported by expected relationships with external correlates. Conclusions: Both versions of the SSRMI scale are valid and reliable instruments appropriate for use in clinical/research contexts.
3646167.pdf
Creators: name: Magrini, Lorenzo
name: Norte, Richard
name: Riedinger, Ralf
name: Marinković, Igor
name: Grass, David
name: Delić, Uroš
name: Gröblacher, Simon
name: Hong, Sungkun
name: Aspelmeyer, Markus
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental Document that contains additional information about the detailed experimental procedures and relevant theoretical background of the works presented in the main manuscript
Transient spurious intrathecal immunoglobulin synthesis in neurological patients after therapeutic apheresis
Creators: name: Berger, Benjamin
name: Hottenrott, Tilman
name: Leubner, Jonas
name: Dersch, Rick
name: Rauer, Sebastian
name: Stich, Oliver
name: Prüss, Harald
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Guillain-Barré syndrome
subject: Plasmapheresis
subject: Immunoadsorption
subject: Cerebrospinal fluid
subject: Intrathecal synthesis of immunoglobulins
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The analysis of cerebrospinal fluid (CSF) is usually done under steady-state conditions, when proteins (e.g., immunoglobulins) reach diffusion equilibrium between blood and CSF. However, little data has been published on CSF analysis under non-steady-state conditions after therapeutic apheresis. By reducing serum proteins (e.g., immunoglobulins), while leaving CSF unchanged, therapeutic apheresis might cause spuriously altered intrathecal immunoglobulin fractions. Methods Based on the incidental finding of plasma exchange-induced increased intrathecal immunoglobulin fractions in a cohort of 12 unsystematically selected patients with various neurological disorders, we retrospectively investigated CSF results that had been raised during routine diagnostic work-up from 41 consecutive neurological patients (predominantly Guillain-Barré syndrome and autoimmune encephalitis) treated with plasmapheresis or immunoadsorption in a tertiary care university hospital in whom lumbar puncture (LP) was performed after a varying number of treatments of therapeutic apheresis. Results Only when LP was performed 1 day after therapeutic apheresis, spurious quantitative intrathecal immunoglobulin (Ig) synthesis of at least one subclass (IgG, IgA and/or IgM) was found in 68.4 % of the patients, irrespective of the number of treatments, in all age groups and independent of other previous immunotherapies (e.g., steroids). This phenomenon occurred only transiently and was almost always accompanied by an elevation of the IgG index. In one patient, an elevated IgG index was noticed even 2 days after plasmapheresis. Neither quantitative Ig synthesis, nor elevated IgG index was observed when the LP was performed three or more days after therapeutic apheresis. Conclusions Spurious quantitative intrathecal Ig synthesis and increased IgG index are common findings shortly after plasmapheresis or immunoadsorption due to altered serum immunoglobulin levels. Knowledge of this phenomenon is needed for clinicians to prevent false interpretations leading to unnecessary diagnostic and therapeutic procedures. Misdiagnoses can be avoided by considering the characteristic CSF constellation including absence of oligoclonal bands and the close temporal relation to therapeutic apheresis
Heat pump's role in decarbonization of building thermal control in the US midwest
Creators: name: Doak, Austin
Publisher: name: University of Iowa
Year: 2022
Subjects: Building energy
Decarbonization
Heat pumps
Midwest
public abstract

description: Climate change mitigation demands rapid decarbonization; in cold regions such as the US Midwest, building thermal control (BTC) presents a potential for significant cuts in emissions by combining renewable energy with heat pumps. Trends in natural gas and electricity pricing over the period 2007-2020 in the Midwest have significantly upended economic feasibility of this decarbonization approach. Heat pump-based BTC has moved from being cost advantageous in operations but higher GHG emitting (in 2007), to the exact opposite – higher cost but lower emitting (in 2020). Due to energy price fluctuations, the coefficient of performance (COP) required of a heat pump to break even on operational cost with high efficiency natural gas heating has doubled, changing from 2.25 to 4.5 over the period 2007 to 2019. The value of 4.5 is infeasible for all available cold-climate heat pump systems. Thus, while electrification via both air- source and ground-source heat pumps is a commonly identified component of decarbonization plans in the region, actual implementation has declined. However, in recent years (2020-2021) electricity prices have decreased while natural gas prices have increased, resulting in the breakeven COP to decrease to value of 3.8. When comparing to propane, the annual average breakeven COP has not exceeded a value of 2.2 which is achievable by most heat pump systems. Thus, homeowners with propane heating systems would likely experience operating cost saving from switch to electric heat pump system. In northern regions of the Midwest, the colder climate lowers the operational efficiency of ASHP systems which results in increased operational cost relative to natural gas heating but in southern regions electric heat pumps are competitive with high efficiency natural gas furnaces. In all regions of the Midwest except North Dakota, electric heat pumps emit less than that of a natural gas furnace with central air conditioning. Thus electric heat pumps offer an environmental benefit in the form of reduced carbon emissions in all regions of the Midwest while the economic saving are primarily dependent on location. Improvements in heat pump performance, overcoming adoption barriers, and adopting policies that buffer long-term climate solutions against short-term price fluctuations are all needed. In part due to continuing decreases in carbon intensity of electricity, heat pump climate benefits can be substantial over project life cycles; however, there is no current policy mechanism to enable this benefit to be considered relative to short-run economic considerations.
Evaluation of β-hydroxy protected aldehyde 1,3-stereoinduction in Mukaiyama aldol reactions and progress towards the total synthesis of bastimolide A
Creators: name: Howell, Lucas W.
Publisher: name: University of Iowa
Year: 2023
Subjects: bastimolide a
mukaiyama aldol
organic synthesis
polyol
stereoinduction
total synthesis
public abstract

description: Bastimolide A is a polyhydroxy 40-membered lactone that was isolated off the coast of Bocas del Toro, Panama in 2015. Bioactivity experiments revealed that it possesses potent (IC50 = 80–270 nM) anti-malarial activity against four drug resistant strains of P. falciparum. Bastimolide A does not share the same structural motifs compared to other known anti-malarial active compounds; therefore, it presumably inhibits malaria via an unknown mechanism of action. Coupling this with the fact that it possesses multiple 1,5-diols, which allows for application of our configuration-encoded 1,5-polyol methodology, bastimolide A is a desirable target for our group to pursue and investigate.
description: We envision a convergent approach that unionizes two fragments, C2–C21 (“Fragment A”) and C22–C43 (“Fragment B”). The northern Fragment A is the main focus of the work presented herein, while my colleague, Jacob Hackbarth, worked towards Fragment B. Fragment A could be accessed from commercially available 1-octenol by applying two prior methods in our group – (1) a detour around our silyl cation-induced ring-opening of enol ester epoxides that includes hydrolysis of a halohydrin ester and (2) configuration-encoded 1,5-polyol synthesis – an iterative approach using Julia Kocienski olefination. These two methods are also the core of the synthesis of Fragment B.
description: Inspiration from prior work in our group led to a plan for joining Fragments A and B via an asymmetric BF3•OEt2-mediated Mukaiyama aldol reaction with high 1,3-anti stereoinduction. Fragment A is a β-silyloxy aldehyde that lacks branching at the γ-carbon, and is the electrophilic partner of the anti-selective Mukaiyama aldol reaction. The resultant stereocenter produced from the aldol is influenced by 1,3-stereoinduction of the nearby β-silyloxy group. A short study was conducted to identify the optimal β-hydroxy protecting group by performing Mukaiyama aldol reactions with β-silyloxy- and β-alkoxy aldehyde analogs where only the protecting group was changed to measure the effect on 1,3-stereoinduction. Broader impacts of this stereoinduction study include further refinement of Evans 1,3- merged stereoinduction model, aiding in future polyketide (polyacetate) synthesis, and experimental benchmarks for computational studies.
description: Once C2–C43 of bastimolide A is in-hand, we aim to complete the total synthesis by alkene hydrogenation, Horner-Wadsworth-Emmons (HWE) olefination, and macrolactonization ring-closure. Smith and coworkers completed the first total synthesis of bastimolide A in May 2022, so inspiration will likely be draw upon their work as unforeseen reactivity was observed and optimization was needed for their final steps.
A novel, well-resolved direct laser bioprinting system for rapid cell encapsulation and microwell fabrication
Creators: name: Wang, Zongjie
name: Jin, Xian
name: Tian, Zhenlin
name: Menard, Frederic
name: Holzman, Jonathan
name: Kim, Keekyoung
Publisher: name: Wiley
Year: 2021

description: A direct laser bioprinting (DLBP) system is introduced in this work. The DLBP system applies visible-laser-induced photocrosslinking at a wavelength of 405 nm using the photoinitiator VA086. It is shown that such a system can fabricate vertical structures with fine features (less than 50 μm), and high cell viability (greater than 95%). Experimental characterizations and theoretical simulations are presented, with good agreement seen between the experiments and theory. The DLBP system is applied to the fabrication of (1) cell-laden hydrogel microgrids, (2) hydrogel microwells, as well as a test of (3) cell encapsulation, and (4) cell seeding. The DLBP system is found to be a promising tool for bioprinting.
Pascal and Wittgenstein : common epistemological elements in the Pensées and On certainty.
Creators: name: Moran, Patrick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Philosophy.

description: The guiding intuition behind this disquisition is that Blaise Pascal and Ludwig Wittgenstein are similar philosophers with similar philosophies. This intuition is not argued in its entirety here. Instead, the author seeks to establish a limited version of this intuition as his thesis; viz., that Wittgenstein and Pascal share six elements of their theories of knowledge. The author executes a demonstration of this thesis by contrasting Wittgenstein's epistemology with G. E. Moore's and contrasting Pascal's epistemology with Rene Descartes'. By showing that Wittgenstein's epistemology contrasts with G. E. Moore's in the same way that Pascal's epistemology contrasts with Descartes', the author is able to conclude that Wittgenstein's theory of knowledge is indeed similar to Pascal's with respect to the six elements mentioned above.
Effects of Helmet Mounted Display symbology and spatial audio cueing on spatial disorientation prevention and recovery
Creators: name: Brown, James Elwin
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: Spatial Disorientation (SD) is a major aeromedical/physiological factor in aviation accidents and encompasses a significant number of destroyed aircraft, fatalities, and monetary costs. Historically, SD has been a factor in approximately 13% of United States Air Force (USAF) mishaps, occurring at a rate across all aircraft types at 0.36 accidents per 100,000 flying hours, approximating to about $33M per mishap in monetary costs. With the development of Helmet Mounted Displays (HMDs) beginning in the 1950s, they have since advanced and are currently fielded on many platforms, such as fighter/attack aircraft. The current generation of HMDs project symbology onto the visor or near eye reticle of the pilot, providing a virtual Head-Up Display (vHUD) and weapons/targeting information. Currently, researchers are focusing on the addition of attitude information to the HMD in a way that provides enhanced aircraft situation awareness, prevents and mitigates SD susceptibility, and aids in recovery from unusual attitudes. Previous research has shown flight performance benefits when attitude information is added to an HMD. The aim of this thesis was to assess the effectiveness of three different symbologies (Current Display Format (CDF), Conformal Reference (CF), and Forward Reference (FR)) in regard to EP flight technical performance and spatial disorientation prevention and recovery. The results herein demonstrate significant flight performance benefits when aircraft attitude information is added to the HMD, which, if fielded, may have a profound impact on SD-related mishap rates.
Konservierung mittelalterlicher Glasmalerei im Kontext spezieller materieller und umweltbedingter Gegebenheiten
Creators: name: Bornschein, Falko
name: Torge, Manfred
name: Sabel, Martin
name: Feldmann, Ines
name: Kohl, Anka
name: Sterzing, Nicole
name: Hahn, Oliver
name: Drewello, Rainer
name: Wetter, Nils
name: Rahrig, Max
name: Bellendorf, Paul
Publisher: name: Dom zu Erfurt St. Marien, Domkapitel
Year: 2010
Subjects: Conservation science

description: Die mittelalterlichen Glasmalereien im Hohen Chor des Erfurter Doms gehören zu den wertvollsten ihrer Gattung in Deutschland. Doch ihr Bestand ist gefährdet: Die im Mittelalter hergestellten Flach- gläser sind unbeständig gegenüber Umwelteinflüssen. Auf der Außenseite dieser Fenster hat sich eine Korrosionsschicht gebildet, der so genannte Wetterstein. Der dadurch eingeschränkte Lichtein- fall beeinträchtigt die Lesbarkeit und das Farbenspiel der Fenster. Manche Darstellungen sind kaum noch zu erkennen. Die Restaurierungsarbeiten am ersten Fenster auf der Nordseite stellten das KUR-Projekt vor neue Anforderungen, da die zwischen 1909 und 1911 auf der Innenseite der Fenster erfolgten restaurato- rischen Eingriffe zu berücksichtigen sind. In naturwissenschaftlichen Voruntersuchungen werden die Schadensbilder analysiert, um die optimalen Methoden für die anstehenden Restaurierungsmaßnah- men zu ermitteln. Darüber hinaus sollen Umwelteinflüsse und frühere restauratorische Eingriffe un- tersucht werden, die als Ursache für heutige Schäden an Glasmalereien dieser Art vermutet werden. Ein innovatives 3D-Monitoring zeigt künftig ein mögliches Fortschreiten der Korrosion an. Aus dem Projekt erhoffen sich Fachleute wertvolle Erkenntnisse für die Erhaltung von Glasmalereien.
Process model for two-dimensional braiding of elliptical cross-section preforms.
Creators: name: Eustace, Stephen A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Mechanical.

description: One form of composite material consists of an amorphous matrix (generally a polymer) with a set of fibres contained in fibre bundles or strands, embedded within it. Often the strands are arranged in an interwoven fabric. Two-dimensional (2D) braiding provides one means of creating such a fabric. The composite's properties depend very much on the configuration of the strands. This configuration depends on aspects of the braiding process, such as machine size and machine speeds. Thus there is a need to establish the relationships between the process parameters and the resulting configuration for braiding processes. In this research effort, relationships of this type were developed for hollow tubular fabric "preforms" with an elliptical cross-section that varies in size along the product's length. These relationships take the form of both single line equations and algorithms with several inherent equations and decision steps. The algorithms give the property distributions over the preform surface. Relationships were developed for both steady state and transient processes. The algorithms, which were run for various process and mandrel conditions, gave reasonable results. When run for circular cylindrical preforms, the results agreed with previously published work.
Neue Therapieansätze für die Behandlung Embryonaler Tumoren im Kindesalter
Creators: name: Künkele, Annette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: chimeric antigen receptor
subject: T cell adoptive therapy
subject: pediatric tumors
subject: TP53 signaling pathway
subject: embryonal tumors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die Heilungschancen für Kinder mit therapierefraktärem oder rezidiviertem Medullo- oder Neuroblastom sind weiterhin schlecht und die Langzeitnebenwirkungen schränken die Betroffenen teilweise ihr Leben lang ein. Daher ist die Entwicklung neuer Therapieformen, die gezielt Krebszellen erkennen und zerstören, essentiell. Große Beachtung finden die sogenannten „small molecules“, die bestimmte tumorspezifische Signalwege angreifen. Wir haben drei verschiedene Inhibitoren des für die Tumorentstehung essentiellen TP53-MDM2-Signalweges in Medullo- und Neuroblastom Zellkultur- und Mausmodellen untersucht. Dabei konnten wir zeigen, dass diese Inhibitoren, teilweise unabhängig des TP53-Status, das Wachstum der Tumorzellen verhinderte. Weiterhin konnten wir keine toxischen Nebenwirkungen in den präklinischen Mausversuchen beobachten. Eine weitere vielversprechende Therapieform stellt die CAR-T-Zelltherapie dar. Hier werden patienteneigene T-Zellen entnommen, gentechnisch modifiziert, so dass sie nach einer Reinfusion in der Lage sind, gezielt Antigene zu erkennen und die antigenpräsentierende Zelle zu zerstören. In unserem Fall ist die antigenpräsentierende Zelle eine Krebszelle. Während diese Therapie in den USA und in China schon in zahlreichen klinischen Phase-I/II-Studien getestet wird, gibt es in Deutschland noch keine Einrichtung mit einem fest etablierten Prozess der GMP-gerechten CAR-T-Zellherstellung. Wir stehen kurz vor der Beantragung einer Herstellungserlaubnis beim Landesamt für Gesundheit und Soziales in Berlin, um an der Charité CD19-spezifische CAR-T-Zellen herstellen zu dürfen. Ähnliche herausragende Ansprechraten, wie sie bei der CD19-spezifischen CAR-T-Zelltherapie beobachtet wurden, wurden für CAR-T-Zellen, die in Phase-I/II-Studien zur Behandlung von Patienten mit soliden Tumoren eingesetzt werden, noch nicht erreicht. In ersten präklinischen Versuchen konnten wir zeigen, dass eine Kombinationstherapie mit „small molecules“, die spezielle Signalwege, Mutationen oder die Tumorumgebung angreifen, zum einen zu einer Effektivitätssteigerung der CAR-T-Zellen führt und zum anderen einer Resistenzbildung vorbeugt. Um sinnvolle Kombinationstherapien zu entwickeln, ist ein grundlegendes Verständnis der molekularen Genetik und der zellulären Mechanismen und Signalwege, welche Krebs vorantreiben notwendig. Zusätzlich muss in geeigneten präklinischen Modellen untersucht werden, ob eine Kombination zu einem synergistischen Effekt führt oder sich die Therapieformen gegenseitig in ihrer anti-tumoralen Wirkung beeinträchtigen. Zuletzt müssen diese präklinischen Ergebnisse konsequent in frühen klinischen pädiatrischen Studien an spezialisierten Kliniken umgesetzt werden.
Cutting polygons and a problem on illumination of stages.
Creators: name: Contreras, Felipe.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Theater.

description: This work presents the solution to two problems in Computational Geometry. First, we introduce an algorithm to calculate (provided an O( n log n) preprocessing or linear if the polygon is convex) the area of an n-gon "cut" by a query interior segment in O(n log n) time. As an application we also show how to find the line cutting 1r of the area of a convex polygon and parallel to a given line. Secondly, we show how to illuminate a stage represented by a line segment s , with floodlights placed at n points above s such that the sum of their angles is minimized. The algorithm runs in theta(n log n) time and we include a videotape presenting it.
Aufbau und öffentliche Kommunikation eines wissenschafts-basierten Sammlungsmanagements für naturkundliche Nasssammlungen
Creators: name: Neuhaus, Birger
Publisher: name: Museum für Naturkunde, Berlin
Year: 2012
Subjects: Conservation

description: Im Rahmen eines von der Kulturstiftung des Bundes und der Kulturstiftung der Länder geförderten Projektes zum Erhalt naturkundlicher Nasssammlungen wurden
1) der Zustand der Sammlungen bewertet (Profiling; Analyse der Vergällungsmittel),
2) über Workshops Expertenwissen in das Projekt gebracht,
3) neue archivbeständige Materialien und Managementmaßnahmen eingeführt (Borosilikat-Gläser und - Röhrchen, Augenwatte, Tefloneinlagen, Japanpapier, archivbeständige Kleber und Papier, Etikettenaufbewahrung; digitales Dichtemessgerät, Alcomon-Indikator, Kontrollintervalle),
4) Erhaltungsmaßnahmen zur langfristigen Konservierung in großem Umfange durchgeführt (Messen der Alkoholkonzentration, Umsetzen von Präparaten in geeignetere Gefäße, Wiederverschluss von Schaugläsern) und
5) Erfahrungen und Diskussionsergebnisse zusammengestellt, nicht ohne auf Wissenslücken und wünschenswerte Forschungsaspekte hinzuweisen.
Das Projekt profitierte besonders von der Expertise aus den Materialwissenschaften und der Papierrestaurierung. Das Museum für Naturkunde Berlin kooperierte eng mit dem Berliner Medizinhistorischen Museum der Charité, der Zoologischen Staatssammlung München und dem Forschungsinstitut Senckenberg in Frankfurt. Letzteres Museum führte ein eigenes, themenverwandtes KUR-Projekt Restauration der Sammlungen "Vergleichende Anatomie, Embryologie und Histologie" des Naturmuseums Senckenberg durch.
title: Untangling the bramble
title: establishing defining ranges of multimodal composition in three classroom studies
titleType: Subtitle
Creators: name: Goldberg, Michael
Publisher: name: University of Iowa
Year: 2023
Subjects: Born-digital
Composition
Digital literacies
Multiliteracies
Multimodal composition
Multimodality
public abstract

description: What role does multimodal composition play in the modern secondary English Language Arts (ELA) classroom? How can we bring useful nuance to the definition of multimodal composition, in ways that can help teachers plan and support effective composition assignments that use a variety of modalities? In this dissertation, I establish three defining ranges:
description: 1. Alphabetic: how central is alphabetic composition and oral/written language to the composition?
description: 2. Digital: how offline or online is the composing, both in process and product?
description: 3. Thinking Multimodally: to what degree and in how many modalities will composers need experience?
description: Using three studies of students composing in classrooms from secondary to graduate school, I set bounds to these ranges and discuss the breadth of composition acts that can be defined as multimodal. These studies center a theater student at an arts-focused summer camp, two pre-service secondary ELA teachers, and my own attempts at a website-based autoethnographic memoir. Each study illustrates segments of the three ranges, speaks to the variety of tasks that multimodal composition describes, and offers ways to expand the variety of modalities students and teachers can practice in their ELA classroom.
description: Based on a pedagogy of multiliteracies, I believe multimodal composition more accurately reflects how students are and will be composing inside and outside of school. It also provides more pathways for students to find their authentic voices, and provides opportunities for students to learn and practice a broader array of contemporary tools for communicating knowledge in an ELA classroom.
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors
Creators: name: Larsen, Esben Kjær Unmack
name: Nielsen, Thomas
name: Wittenborn, Thomas
name: Rydtoft, Louise Munk
name: Lokanathan, Arcot R.
name: Hansen, Line
name: Østergaard, Leif
name: Kingshott, Peter
name: Howard, Kenneth A.
name: Besenbacher, Flemming
name: Nielsen, Niels Chr.
name: Kjems, Jørgen
Publisher: name: Swinburne
Year: 2024

description: Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333-20 000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (Mw) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating Mw of 10 000 Da.
Free radical cyclizations onto -C=N-R acceptors: Kinetics and synthetic applications and synthesis of taxoid mimics.
Creators: name: Tauh, Poonam.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Chemistry, Organic.

description: The kinetics for the 5-exo cyclizations of secondary alkyl radicals onto various imine acceptors (alkyl-, aryl-, benzoylhydrazones, oxime ethers, etc) have been determined. The preparation of a series of halo C=N containing "bis imine" systems (182 a--i ) for use in kinetic studies has been described. The rate constants have been established by competitive "internal radical clock" type cyclizations on the basis of the known rate constants for alkene and N,N-diphenylhydrazone systems. In refluxing benzene the rate constants for these 5-exo cyclizations fall within the range of 4 x 107 to 16 x 107 s-1 depending on the electron withdrawing capacity of the imine acceptor. These rate constants are approximately 200 times faster than those for the corresponding 5-exo cyclizations onto alkenes. The fastest rate constants were observed for the N,N-diphenylhydrazones and N-benzoylhydrazones. N,N-Diphenylhydrazones were further employed in the formation of nitrogen containing bicyclic systems via tandem radical cyclizations. Tandem products were obtained for 5,5- and 6,5-bicyclic systems. Attempted synthesis of 5,6- and 6,6-bicyclic systems via tandem cyclizations resulted only in the formation of monocylized products 284 and 285 respectively. A new chiral auxiliary 327 was synthesized for use in the study of asymmetric induction in radical cyclizations in the presence of chiral auxiliaries in systems such as 328b. In search of "taxoid mimics" with less functionality and better therapeutic profile as compared to the anti cancer drug "Taxol", small taxol like compounds 350 and 351 were synthesized and their biological activity was evaluated.
title: Total Aortic Arch Replacement
title: Superior Ventriculo-Arterial Coupling with Decellularized Allografts Compared with Conventional Prostheses
titleType: Subtitle
Creators: name: Weymann, Alexander
name: Radovits, Tamás
name: Schmack, Bastian
name: Korkmaz, Sevil
name: Li, Shiliang
name: Chaimow, Nicole
name: Pätzold, Ines
name: Becher, Peter Moritz
name: Hartyánszky, István
name: Soós, Pál
name: Merkely, Gergo
name: Németh, Balázs Tamás
name: Istók, Roland
name: Veres, Gábor
name: Merkely, Béla
name: Terytze, Konstantin
name: Karck, Matthias
name: Szabó, Gábor
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement. This study investigated ventriculoarterial coupling and vascular impedance after replacement of the aortic arch with conventional prostheses vs. decellularized allografts. Methods After preparing decellularized aortic arch allografts, their mechanical, histological and biochemical properties were evaluated and compared to native aortic arches and conventional prostheses in vitro. In open-chest dogs, total aortic arch replacement was performed with conventional prostheses and compared to decellularized allografts (n = 5/group). Aortic flow and pressure were recorded continuously, left ventricular pressure-volume relations were measured by using a pressure- conductance catheter. From the hemodynamic variables end-systolic elastance (Ees), arterial elastance (Ea) and ventriculoarterial coupling were calculated. Characteristic impedance (Z) was assessed by Fourier analysis. Results While Ees did not differ between the groups and over time (4.1±1.19 vs. 4.58±1.39 mmHg/mL and 3.21±0.97 vs. 3.96±1.16 mmHg/mL), Ea showed a higher increase in the prosthesis group (4.01±0.67 vs. 6.18±0.20 mmHg/mL, P<0.05) in comparison to decellularized allografts (5.03±0.35 vs. 5.99±1.09 mmHg/mL). This led to impaired ventriculoarterial coupling in the prosthesis group, while it remained unchanged in the allograft group (62.5±50.9 vs. 3.9±23.4%). Z showed a strong increasing tendency in the prosthesis group and it was markedly higher after replacement when compared to decellularized allografts (44.6±8.3dyn·sec·cm−5 vs. 32.4±2.0dyn·sec·cm−5, P<0.05). Conclusions Total aortic arch replacement leads to contractility-afterload mismatch by means of increased impedance and invert ventriculoarterial coupling ratio after implantation of conventional prostheses. Implantation of decellularized allografts preserves vascular impedance thereby improving ventriculoarterial mechanoenergetics after aortic arch replacement.
Interpretation and violence: Reason, narrative, and religious toleration in the works of John Milton.
Creators: name: Donnelly, Phillip Johnathan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Literature, English.

description: This dissertation is a study of the prose and poetry of John Milton (1608--1674). It considers how his poetic practice was shaped by the sustained attempt to argue for religious toleration. The first stage of the analysis examines, in Chapter 1, the theological basis for arguments justifying the use of religious coercion in seventeenth-century Britain. Chapter 2 then considers Milton's response to such arguments in his pre-Restoration prose. This first part of the argument clarifies one of the most urgent questions that constituted the horizon of expectations to which Milton's writing was addressed. The second stage considers, in Chapter 3, the debate over whether Milton authored the Ramist treatise De Doctrina Christiana, in order to understand how he attempts to move beyond the stylistic limitations of customary theological and theoretical discourse. Chapter 4 compares the apparently contrasting accounts of rational truth presented in Areopagitica and Artis Logicae Plenior Institutio in order to establish a precise account of the educative reading process to which Milton exhorts his readers. The third stage of the argument demonstrates how Paradise Lost addresses, by the most biblically consistent and subtle means, the root issues of human freedom and divine justice, as they relate ultimately to arguments regarding the use of state coercion in religious causes. The analysis considers Raphael's narration of the war in heaven (books 5 and 6), the account of the Fall and its consequences (books 9 and 10), and Michael's account of biblical history (books 11 and 12). The argument shows the poem's exceptional capacity to engage the issues of coercion, charity, and biblical truth by a necessarily indirect means that recapitulates within itself the whole of the biblical story. In effect, the epic poses for its English Protestant readers a necessary choice between either advocating religious toleration or abandoning their own sense of authentic Christian faith. The conclusion briefly considers how the preceding account of Paradise Lost leads also to a new understanding of Paradise Regained.
title: Survey on the usage of marking by professional singers
title: the operatic stage and beyond
titleType: Subtitle
Creators: name: Williams, John Elson
Publisher: name: University of Iowa
Year: 2022
Subjects: Conserving Voice
Marking
Singing
Stamina
Vocal Pedagogy
Voice
public abstract

description: The purpose of this study was to identify the approaches that singers utilize while marking during singing. Marking is the global term for how singers preserve their voice while continuing to being engaged in the rehearsal process. Participants in the study were singers with five to ten years of professional singing experience, with at least a master’ degree in music or theater, and who sing in opera, musical theater, professional choirs, sacred music in church jobs or contemporary commercial music (CCM), which consists of any popular styles, including rap, rhythm and blues, country, soul, rock, gospel, and pop. Participants were contacted using Facebook and the National Association of Teachers of Singing database. An online questionnaire was monitored through survey processes according to the Institutional Review Board of the University of Iowa. Results demonstrated that the utilization of marking is situational and that healthy vocal practices are not only the responsibility of the singer, but also the person leading rehearsal. While some singers indicated that they do not practice marking, many of them revealed that they practice marking while learning music by focusing on components of the music such as vowels, the meaning of the words, and breathing.
The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
Creators: name: Weiss, William Michael.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Biology, Molecular.

description: The role of Th1 (IL,-2 and IFN-gamma) and Th2 (IL-4 and IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood and constituted the major aim of this investigation. To understand the molecular mechanisms of chemokine receptor down regulation induced by Th1 and Th2 cytokines, the expression of mRNA encoding CXCR4 and CCR5 was examined. The functional consequences of decreases in CXCR4 and CCR5 expression by Th1 and Th2 cytokines were investigated by chemotactic assays. Monocytes from HIV negative adults, HIV positive adults, and HIV negative cord blood were cultured in the presence and absence of Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-13) cytokines before their ability to migrate in response to the CXCR4 ligand SDF-1, and the CCR5 ligand MIP-1alpha, were measured. The consequences of decreases in CXCR4 and CCR5 expression by Th1 and Th2 cytokines were also investigated with respect to HIV entry and replication. (Abstract shortened by UMI.)
ISP liability for end-user copyright infringements: the High Court decision in Roadshow Films v iiNet
Creators: name: Lindsay, David
Publisher: name: Swinburne
Year: 2024

description: In Roadshow Films v iiNet, the High Court unanimously held that iiNet was not liable for copyright infringements committed by its subscribers by means of the BitTorrent peer-to-peer file-sharing system. While the two judgments delivered by the High Court have clarified the extent to which ISPs may be liable for end-user infringements, they have created considerable legal uncertainty about authorisation liability, which is the main Australian doctrine under which a person may be found liable for the infringing conduct of another person. This article explains and analyses the two judgments delivered by the High Court in iiNet, focussing on the implications of the decision for ISPs, and for authorisation liability more generally. The evidence establishes that detection ⋯ followed by warning over three occasions and eventual discontinuance of Internet access will succeed in strongly alleviating the problem of Internet piracy. EMI Records (Ireland) Ltd v UPC Communications Ireland Ltd [2010] IEHC 377 at [71] per Charleton J. Was it a reasonable step to require of iiNet that it monitor continually the activities of IP addresses to provide precise details of primary infringements that had been committed, and then take further steps to forestall further infringements? Warnings might or might not have that effect. Evidence was lacking of likely behaviour in that respect by users of ISP facilities. Roadshow Films Pty Ltd v iiNet Ltd ((2012) 286 ALR 466, 498) per Gummow and Hayne JJ.
The home food environment and associations with dietary intake among adolescents presenting for a lifestyle modification intervention
Creators: name: Watts, Allison W.
name: Barr, Susan I.
name: Hanning, Rhona M.
name: Lovato, Chris Y.
name: Mâsse, Louise C.
Publisher: name: BioMed Central
Year: 2018

description: Background: The home food environment may be an important target for addressing adolescent obesity. The aim of this study was to investigate associations between aspects of the home food environment and the diets of adolescents who present for obesity treatment. Methods: Cross-sectional baseline data were collected from 167 overweight/obese adolescent-parent pairs participating in an e-health lifestyle modification intervention. Adolescent intake of specific foods (fruit and vegetables, total fat, sugar-sweetened beverages, desserts/treats, and snacking occasions) was assessed by three 24-h dietary recalls, while household factors were collected from adolescent and parent questionnaires. Structural Equation Modeling, controlling for relevant covariates, was used to examine the relationship between adolescent diet and the following household factors: parent modeling, parenting style, family meal practices, and home food/beverage availability. Results: Findings reveal that few characteristics of the home food environment were associated with adolescent dietary intake. Greater home availability of high-fat foods was moderately associated with adolescent snack intake (β = 0.27, p < .001). Associations with fruit/vegetables and fat intake were small and some were in unexpected directions. Parent modeling of healthful food choices and healthier family meal practices were associated with lower availability of high-fat foods and treats in the home, but were not directly associated with adolescent diets. Conclusions: Parent modeling of healthy foods and positive mealtime routines might contribute to the healthfulness of foods offered in the homes of adolescents who are overweight/obese. Additional research is needed to better characterize the complex aspects of the household environment that influence adolescent diet.
Characterizing the signatures of electron Landau damping throughout the inner heliosphere
Creators: name: Conley, Sarah A.
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: A long-standing goal in the heliophysics community is to understand the mechanisms of particle energization that dissipate turbulent energy in the weakly collisional plasma of the solar wind. One mechanism that is thought to play a major role is Landau damping, though the extent to which it contributes to turbulence dissipation in the solar wind remains unclear. Despite decades of study, the small length scales and fast time scales at which these mechanisms operate make them difficult to simulate or observe \emph{in situ}. Recently, however, Landau damping by electrons became the first of the many proposed turbulence dissipation mechanisms to be observed using the field-particle correlation technique. This recently developed method uses single-point observations of electromagnetic fields and particle velocity distribution functions to reveal velocity-space signatures of particle energization that are distinct to the various dissipation mechanisms. Motivated by the first \emph{in situ} observation of Landau damping in Earth's magnetosheath, the goal of this thesis is to characterize signatures of particle energization via electron Landau damping under solar wind conditions in order to develop a more complete understanding of how this mechanism may be observed. We do this by generating high-resolution, gyrokinetic simulations of plasma turbulence and applying the field-particle correlation technique to the simulation data. First, we perform a case-study analysis to corroborate the observed field-particle correlation signature of electron Landau damping by generating a simulation of magnetosheath plasma turbulence. Next, we consider how signatures of electron Landau damping vary throughout the inner heliosphere by using a suite of four gyrokinetic turbulence simulations with varying plasma-$\beta$. Finally, we demonstrate the ability of the field-particle correlation technique to recover velocity-space signatures of resonant Landau damping when the frequency of the damped \Alfven wave is above the Nyquist frequency of the spacecraft. Since this occurs even for modern spacecraft like the \emph{Magnetospheric Multiscale Mission} and \emph{Parker Solar Probe}, we develop a rule-of-thumb model for using field-particle correlations to recover \emph{in situ} signatures in under-sampled conditions. Our results expand existing theory on identifying electron Landau damping in the heliosphere and create context for future applications of the field-particle correlation technique to spacecraft data.