cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Operations scheduling with delivery deadlines in multi-echelon supply chains
Creators: name: Wang, Gang
Publisher: name: No Publisher Supplied
Year: 2012

description: We study the operations scheduling problem with delivery deadlines over capacitated multi-echelon shipping networks. Our main results consist of new mathematical models, structural analysis, and solution methodologies for this type of operations scheduling problems, which are in general computationally difficult due to their inherent combinatorial nature.        Part I of the dissertation investigates three polynomial-time solvable cases, including case 1) identical order sizes; case 2) designated suppliers; and case 3) divisible order sizes. For the first case, we prove that the original problem can be decomposed into two sub-problems: the transportation problem and a specially structured mixed integer programming model that is totally unimodular. For the second case, we show that the original problem can be solved by the Minimal Spanning Tree algorithm that runs in polynomial time. The third case is shown to be solvable in polynomial time by extending the literature results for a special case of the well- known bin packing problem. Part II of this dissertation analyzes the structure properties of the network scheduling problem with a single processing center (PC) between the suppliers and customers.  A dynamic programming-based search algorithm that correctly identifies the optimal subset of customer orders to be fulfilled under each given utilization level of the PC capacity is proposed. We also prove that the resulting search algorithm converges to the optimal solution within pseudo-polynomial time.  Part III of the dissertation focuses on the methodology of solving the general operations scheduling problems with customer delivery deadlines. We propose a linear programming relaxation-based algorithm. With this algorithm, a given network scheduling problem is solved through an iterative process. During each iteration, a threshold parameter is used to select the relaxed linear variables to be binary variables for the next iteration, while a subset of binary variables is still relaxed to bounded linear variables. The iteration continues until the values of all the binary variables are determined. This partial relaxation allows us to avoid dealing with the generalized knapsack problem, a difficult NP-hard problem, in the solution process.
The effect of interleukin 17 on oligodendrocyte proliferation and differentiation
Creators: name: Tetteh, Sandra
Publisher: name: No Publisher Supplied
Year: 2012

description: Interleukin-17 (IL-17) is a cytokine that may cross the blood-brain barrier to promote inflammation and participate in the formation of lesions in patients with multiple sclerosis, where recurrent inflammatory attacks lead to oligodendrocyte loss, loss of axons, and ensuing neurological infirmities. Studies have indicated that the levels of IL-17 mRNA are elevated in the cerebrospinal fluid of multiple sclerosis (MS) patients, and microarray analysis of MS lesions show elevated levels of IL-17 transcripts. In this study we set up an in vitro system to examine the role of IL-17 on oligodendrocyte precursor cell (OPC) proliferation and their differentiation into mature oligodendrocytes (OLs). OPCs were treated with increasing doses of IL-17 (0.03 nM, 0.1 nM, 0.3 nM, 0.9 nM) in the presence of PDGF and FGF, and the effect on proliferation was assessed by BrdU uptake. The results show that while IL-17 alone had nominal mitogenic effect on OPCs it promoted growth factor induced proliferation (p<0.0001). Interestingly, the effect on proliferation was only seen at low doses of IL-17, whereas at high doses, the cytokine inhibited OPC proliferation. IL-17 did not have any significant effect on OPC differentiation in culture. All together these results show a dose-dependent effect by IL-17 on OPC proliferation. Additional experiments will be important to further elucidate the role of IL-17 on the oligodendrocyte lineage formation.
The role of Nrg1-ErbB signaling in promoting Schwann cell myelination
Creators: name: Syed, Neeraja
Publisher: name: No Publisher Supplied
Year: 2012

description: Myelination is important for rapid saltatory conduction of nerve signals along the axons. Under various pathological conditions, myelin is lost and rebuilding myelin is required for functional recovery. In the PNS, myelination is regulated by axonal signals. Therefore, enhancing the promyelinating signals could be used as a therapeutic strategy to improve myelin repair by endogenous or transplanted myelinating glial cells such as Schwann cells. Recent studies identified Nrg1-type III as an important promyelinating signal that regulate Schwann cell myelination. Therefore, we hypothesized that providing an ectopic Nrg1-type III signal in a soluble form would increase the myelinating potential of Schwann cells. Since Nrg1-type III is normally expressed by axons as a membrane bound protein, in Aim 1 we first characterized the signaling function and the therapeutic potential of soluble Nrg1-type III in Schwann cells. Results from this study show that soluble Nrg1-type III elicits a promyelinating effect in-vitro: it increases myelin gene expression and enhances myelination on axons that express low levels of Nrg1-type III. However, when used at high concentrations it has a contrasting effect and inhibits myelination. Remyelination in the adult PNS is often incomplete: the myelin segments are thin and short. To determine the cell type that contributes to the defect, we characterized the myelination potentials of Schwann cells and neurons isolated from adult PNS in Aim 2. Results show that while adult Schwann cells myelinate normally, the axons provide insufficient promyelinating signals by expressing low levels of Nrg1-type III. In Aim 3, we investigated whether providing ectopic Nrg1-type III improves myelination on adult axons. Surprisingly, neither treatment with soluble nor over expressing membrane bound Nrg1-type III was sufficient to enhance myelination on adult axons. Further analysis revealed that adult axons increases Erk1/2 activity in the associated Schwann cells, an inhibitory signal for myelination. Inhibiting those signals significantly increase myelination on adult axons.
Lichnocythere tubrabucca Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Lichnocythere
Lichnocythere tubrabucca

description: Lichnocythere tubrabucca Hart & Hart, 1967
1967b Lichnocythere tubrabucca sp. nov. —Hart & Hart: 6, 7, 8, 19, 21, 24, 25, 26, 46, 47, Figs. 70–74 (A, D, H, K, R, T).
1969a Lichnocythere tubrabucca Hart and Hart, 1967.—Hart & Hart: 180, 181, Fig. 4 (T).
1969b Lichnocythere tubrabucca.—Hart & Hart: 157, Fig. 4 (H, T).
1973 Lichnocythere tubrabucca Hart and Hart. —McKenzie: 139 (D).
1974 Lichnocythere tubrabucca Hart and Hart, 1967.—Hart & Hart: 145, 155, 217, 237, Pl. XLI Figs. 4–6, Pl. LXI (C, D, H, K, R, T).
1975 Lichnocythere tubrabucca Hart & Hart, 1967.—Hart & Hart: 58 (C, D, H).
2014a Lichnocythere tubrabucca Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 950 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 103, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Hyssopus olivaceus Thomson
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hyssopus
Hyssopus olivaceus

description: 48. Hyssopus olivaceus (Thomson)
Material examined. 1 ♀, Israel, Botanical garden, Tel Aviv, M.T., 1.i.2011 (Z. Yefremova, V. Kravchenko). Hosts. Ectoparasitoid of Coleophoridae (Lepidoptera) (Bouček & Askew 1968). Distribution. Israel *; Palearctic (Bouček & Askew 1968; Bouček 1977; Boyadzhiev 1997, 2004, 2006; Kalina 1989, Vidal 2001).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 13, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Lichnocythere victoria Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Lichnocythere
Lichnocythere victoria

description: * Lichnocythere victoria Hart & Hart, 1967
1967b Lichnocythere victoria sp. nov. —Hart & Hart: 8, 23, 24–25, 26, 28, 44, 45, Figs. 63–66 (A, D, H, K, R, T).
1974 Lichnocythere victoria Hart and Hart, 1967.—Hart & Hart: 145, 154, 155–156, 217, 237, Pl. XLI Figs. 7–10, Pl. LXI (C, D, H, K, T).
1975 Lichnocythere victoria Hart & Hart, 1967.—Hart & Hart: 57, 58 (C, D, H).
2014a Lichnocythere victoria Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 951 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 103, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Photonically Generated Millimetre-Wave and THz Links for Wireless Fronthaul and Backhaul
Creators: name: Fice, M
name: Guerrero, LG
name: Li, T
name: Renaud, CC
name: Seeds, A
name: Penty, R
name: White, I
Publisher: name: IEEE
Year: 2021
Subjects: Wireless networks
millimetre wave
THz
fronthaul
backhaul
optical heterodyne

description: Requirements for backhaul and fronthaul links in future cellular wireless networks and the potential role of photonically generated millimetre-wave and THz wireless signals for these applications are discussed. An experiment demonstrating photonically generated 50 Gb/s 16QAM wireless transmission at 182 GHz for backhaul and 7 Gb/s fronthaul at 31 GHz is presented and analysed. The fronthaul link uses a novel digital radio-over-fibre compression system which allows 14 LTE channels to be transmitted within the 10 Gb/s line rate.
Doing it under the table
Creators: name: Smith, Matthew Grady
Publisher: name: No Publisher Supplied
Year: 2012

description: In developing economies, managers often choose to hide their firms' activities in the informal sector, beyond the reach of government officials. In this dissertation, I examine the factors that drive one widespread form of participation in the informal sector: the hiding or underreporting of sales. In the first study, I present a novel empirical strategy to estimate the extent of sales underreporting using readily available firm financial data. Applying this model to a sample of Indian manufacturing firms over the period from 1999 to 2007, I examine how sales underreporting is influenced by macroeconomic conditions and by the firm's institutional environment, including the regulatory burden and corruption. For robustness, I benchmark my estimates against the World Bank Enterprise Survey dataset for India, which includes data on managers' self-reported hidden sales. Comparison with the survey results provides broad support for the model.    In the second essay, I explore the links between participation in the informal economy and corporate governance. In particular, I argue that unreported sales can be viewed simultaneously as expropriation of shareholders and as participation in the informal economy. Building on the corporate governance literature, I examine the  relationship between informality and two corporate governance mechanisms: the concentration of ownership, and legal protection of minority investors. Using a dataset of 643 publicly listed firms in 14 countries, drawn from the World Bank Enterprise Surveys (WBES), I find that both ownership concentration and the quality of investor protection are important drivers of informality.    In the third essay, I build on the previous two chapters, using the empirical model introduced in the first study to examine the relationship between corporate governance and unreported sales among Indian manufacturing firms. In particular, I examine how underreporting of sales is influenced by ownership concentration, cross-listing on US and European exchanges, and by business group affiliation. As in the cross-country study, I find that ownership concentration significantly influences unreported sales. I also find that cross-listed firms report a larger portion of their sales, consistent with the argument that cross-listing limits the ability of insiders to expropriate value from external investors. Finally, I find that business group affiliated firms engage in more extensive under-reporting of sales. Furthermore, ownership concentration and cross-listing have no influence on the behavior of group firms, suggesting that these governance mechanisms are insufficient to constrain the behavior of insiders of Indian business groups.
Axina parcepunctata Schenkling 1900
Creators: name: Opitz, Weston
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cleridae
Axina
Axina parcepunctata

description: Axina parcepunctata Schenkling, 1900
Figures 19, 70, 87.
Axina parcepunctata Schenkling, 1900: 388. Lectotype. Male. Here designated. Type locality: Goyaz, Bras., Donckier (Brasil) (SDEI). Paralectotypes: 4 specimens. Brazil; Estado do Goias, Collection date not noted, Donckier (FMNH, 1; SDEI, 3). Corporaal 1950: 98. There is indication that Schenkling examined more than one specimen in his description of this species, but he did not select a holotype, therefore, I invoke Recommendation 73F of the ICZN (1999) and designate a lectotype for this nominal species.
Diagnosis. There are only a few asetiferous punctures at the middle of the elytral disc near the sutural margin. This characteristic will distinguish the members of this species from congeners.
Redescription. Size. Length 10.8 mm; width 2.8 mm. Form. As in Fig. 87. Color. Cranium dark castaneous; antenna testaceous; prothorax and pterothorax testaceous; elytra bicolorous, disc mostly flavotestaceous, each elytron with 2 brown fasciae, one faintly visible at elytron middle and one at elytral subapex; legs testaceous, distal half of femora and tibiae slightly darker; abdomen testaceous. Head. Cranium finely punctate, frons slightly narrower than length of antennal pedicel; EW/FW 55/7. Thorax. Pronotum finely punctate, with 2 tumescences, concave at middle; PW/PL 120/135; elytra with few asetiferous punctures concentrated in basal half near sutural margin; EL/EW 500/100. Abdomen. Aedeagus, phallobasic lobes diverge slightly near apex; phallic plates very serrate near phallic apex; phallobasic apodeme abbreviated.
Variation. Size. Length 8.0–14.0 mm; width 2.0– 3.8 mm. The brown transverse fasciae on the elytral disc may only be faintly visible or absent. The elytral base may be completely testaceous.
Natural history. Specimens were collected in Brazil during May and October, one at 960 m. Distribution (for map see Fig. 70). In addition to the lectotype and paralectotypes, I examined 32 specimens from: Brazil: Estado do Rio de Janeiro, Rio de Janeiro,?-X-?. collector not noted; Corcovado, 14-V-1912, G. E. Briant; Estado do São Paulo, Regente Feijo,?- X-1945; Villa Victoria,?-?-1890, Ch. Pujol; Estado do Goiás, Mineiro Goyas, collection date and collector not noted; Rio Verde,?-?-1908, G. A. Baer; Jatai,?- XI-1972, F. M. Oliveira. Specimens are deposited in: AMNH, BMNH, CASC, CMNH, CUIC, FMNH, FSCA, MCNZ, MNHN, SDEI, WFBM, and WOPC.
description: Published as part of Opitz, Weston, 2020, Taxonomic revision of the Western Hemisphere checkered beetle genus Axina Kirby (Coleoptera: Cleridae: Clerinae), pp. 1-70 in Insecta Mundi 2020 (793) on page 19, DOI: 10.5281/zenodo.4564947
A Peptide Vaccine for Breast Cancer Prevention
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer is a serious health problem both in the US and worldwide. In the US alone approximately 182,000 new cases of breast cancer are diagnosed each year and breast cancer is the most common malignancy and the third leading cause of cancer deaths in women (46,000/year). Because most of these deaths are the result of tumor recurrences and metastatic disease, new approaches to prevent disease progression such as immune-based vaccines must be seriously considered. The purpose of this project is to define the capacity of synthetic protein fragments (peptides) to induce cytotoxic T lymphocyte (CTL) responses to antigens expressed on breast tumor cells. Because CTL are the immune cells most capable of directly killing tumor cells, vaccines that induce these immune responses are an attractive way of preventing cancer recurrences or at least inhibiting tumor progression in women with early disease. Most significantly, such vaccines could be used to prevent the occurrence of breast carcinoma in healthy women who are genetically at high risk of developing this disease. This could be accomplished by immunization of young women from families with high rates of breast carcinoma.

 CTL recognize antigenic peptides derived from processed proteins which bind to major histocompatibility gene complex (MHC) molecules. The MHC molecules, also known as the transplantation-rejection antigens, are present in most cells including tumors and have the main function of presenting antigenic peptides to CTL. We aim to identify CTL antigenic peptides in a specific protein called HER2/neu, which is produced in high amounts in aggressive breast tumors. Potential CTL antigens from the HER2/neu protein have already been selected for these studies by the identification of those peptides from the protein that bind to the human MHC molecules. Following a protocol successfully utilized to identify melanoma tumor CTL antigens, we will test the MHC-binding peptides from the HER2/neu protein for breast cancer-specific CTL responses. These experiments will be done in tissue culture using blood lymphocytes from normal volunteers and breast cancer patients. The final goal of this work is to identify several peptides from the HER2/neu protein which are capable of eliciting tumor-specific CTL. The outcome of these studies will be the basis of the development of these peptides into CTL-inducing vaccines used to prevent or delay progression of breast tumors that express the HER2/neu antigen.
Hyssopus geniculatus Hartig
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hyssopus
Hyssopus geniculatus

description: 49. Hyssopus geniculatus (Hartig)
Material examined. 2 ♀, Israel, Regba, ex. Cacoecimorpha pronubana Hübner on avocado, 24.vi.1972 (M. Wysoki); 1 ♂, Mt. Carmel, Nahal Oren, sweeping, 14.iv.2006 (A. Freidberg); 1 ♀, Herzliiyya, 32°11’N; 34°49’E, sweeping, 25.iv.2008 (A. Freidberg); 3 ♀, Ma’agan Mikha’el, M.T., i.2009 (W. Kuslitzky); 1 ♀, Ma’agan Mikha’el, M.T., 10.v.2007 (W. Kuslitzky); 1 ♀, Ma’agan Mikha’el, M.T., 1.ix.2008 (W. Kuslitzky); 1 ♀, Almagor, M.T., 22.ix.2010 (W. Kuslitzky).
Host. Ectoparasitoids of Gelechiidae, Gracillariidae, Pyralidae and Tortricidae (Lepidoptera) (Bouček & Askew 1968); new host-record C. pronubana (Tortricidae).
Distribution. Israel *; Palearctic (Bouček & Askew 1968).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 13, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Blocking Stromelysin-3 to Inhibit Breast Cancer Metastasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastasis, the spread of cells from the primary cancer to distant sites in the body, is the most fearsome aspect of breast cancer. Despite significant advances in breast cancer detection and treatment, most deaths from breast cancer are due to metastasis that is resistant to conventional therapies. Occult or hidden micro-metastases may already exist in women diagnosed with tumors. Metastasis consists of a series of linked, sequential steps that enable tumor cells to secrete tissue-destroying enzymes, which allow cells to break away from the original cancer. Therefore, current drugs that only stop cancer growth may not always halt the metastatic spread of the cancer. Recent studies on breast cancer biopsies reported high levels of a new enzyme, stromelysin-3 (ST-3), particularly from patients who later developed metastasis. ST-3 was found to be involved in the early steps of metastasis, which convert a tumor cell to a metastatic cell. ST-3 belongs to a well-known class of zinc-containing enzymes (matrix metalloproteinases, MMPs), but it has several unique properties. Interestingly, it does not directly break down the extracellular matrix surrounding tumor cells, but instead appears to bind to and inactivate a natural inhibitor of other tissue-destroying enzymes. This then allows these other enzymes to degrade the matrix, leading to metastasis.

 The goal of this proposed research is to target the unique aspects of ST-3 to design and develop a drug that will specifically block the action of ST-3 and thereby halt the process of metastasis in its early stages. We will use a multidisciplinary approach for drug design, which consists of organic synthesis, computer modeling and biological testing. We will target the active site of ST-3 by using small protein-based (dipeptide) inhibitors that incorporate a strong zinc-binding component. We will evaluate the effectiveness of these inhibitors by using both purified ST-3 and whole cell systems to better represent a natural, biological model. Feedback from this biological evaluation will be integrated into the drug design to obtain a therapeutically viable anti-metastatic compound.

 Novel antimetastatic drugs would be especially valuable in combination with surgery and/or chemotherapy. Current widespread use of screening mammography has increased the detection of very small, early-stage breast cancers. Thus, drugs that prevent metastasis would serve to combat recurrence and assure a complete and lasting cure.
The evolution of the innovation network and the technological system in a standard developing organization. The example of cellular telecommunications
Creators: name: Piepenbrink, Anke
Publisher: name: No Publisher Supplied
Year: 2012

description: Standard developing organizations (SDOs) are voluntary inter-organizational collaborations with the goal to develop jointly compatibility standards for complex  modular technological systems.  This dissertation examines the evolution of the innovation network and technological system in a SDO with the perspective of complementing micro and macro level.   The dissertation is rooted in the multidisciplinary complex system theory and draws on a broad range of literature from management, sociology, biology and physics with the common theme of bipartite network analysis.    The innovation network is conceptualized as a bipartite network with ties between organizations and innovations to which they contribute. I show that technical capital, resources in the SDO and their match between organization and innovation, rather than social capital, network position, drive the tie formation in the innovation network.   To answer the question of emerging order in an innovation ecology without formal hierarchy I borrow from the literature of ecological mutualistic networks. I show that a nested order emerges based on a parsimonious process of matching resources, that leads to a rather stable system over more than ten years.     The evolution of the technological system in the SDO environment departs from the established life cycle model and is best described by a life spiral model with continuously increasing system performance rather than punctuated equilibria. The key distinction to market-based technological evolution is the coordinated and designed development process within the SDO, that allows to introduce new services and change core parts of the system based on architectural knowledge. As a consequence the development process follows a gradual change model with changing tempo. Furthermore the evolution is characterized by simultaneity of innovation types that identifies the SDO as ambidextrous organization with separation of exploitation and exploration on project level.    The research context is Third Generation Partnership Project (3GPP) in the cellular telecommunications industry with data from 1992 to 2011.
Notocythere Hart & Hart 1967, gen. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Notocythere

description: ** Notocythere Hart & Hart, 1967
1967b Notocythere gen. nov. —Hart & Hart: 6, 7, 8, 9, 50 [by implication], 51, Fig. 93 (D, K, R, T).
1968 Notocythere.—Sohn: 441 (C).
1974 Notocythere Hart and Hart, 1967.—Hart & Hart: viii, 145, 156, Fig. 47 (C, D, H, K, T).
1974 Notocythere Hart & Hart, 1967.—Hartmann & Puri: 51 (C).
1975 Notocythere Hart & Hart, 1967.—Hart & Hart: 54, 58 (C, D, H).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 103, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Macro-3D carbon nanotube/metallic wool hierarchical hybrids for adsorptive cooling and novel TiO2/graphene composites for photocatalytic applications
Creators: name: Ma, Tao
Publisher: name: No Publisher Supplied
Year: 2012

description: The objective of the research is to develop an innovative approach for a rapid and mass production of macro-3D hierarchical porous hybrids for adsorptive cooling. The most innovative feature of this cooling system is the capability to utilize solar energy or any heat waste as the driving force, which is an energy- favored and environmental-friendly alternative to traditional cooling systems. The macro-3D hierarchical porous hybrids are used as the adsorbent in the cooling system and composed with vertically aligned carbon nanotubes directly grown on highly conductive metal microwires in stainless steel wool. The stainless steel wool has stochastic foam features composed of microwires and pores of wide range of sizes from millimeters down to nanometers. Significantly improved performance for adsorptive cooling by this novel design is expected due to the unique 3D hierarchical porous structures, which not only dramatically increases effective surface area for coolant adsorption and desorption, but also facilitates mass transport of the coolants. Directly growing CNTs on a conductive surface will dramatically improve the contact between the CNTs and the underlying metal substrates, which has been a long-lasting problem and is the key to speed up heat transfer. To reach these goals, several important parameters, such as in-situ catalyst fabrication, growing temperature, flow rates of carbon resourses, reduction and inert carrier gases, were systematically investigated and optimized to grow vertically aligned carbon nanotubes on each metal wire in stainless steel wool. We also have established an adsorptive cooling system to study the cooling cycles using pressure-temperature (P-T) diagram. This system allows us to timely evaluate the refrigeration performance (such as the coefficient of performance, COP) of the fabricated novel 3D hierarchical porous adsorbent.         Another part of this thesis is to fabricate urchin-like or flower-like assembled TiO2 nanorods/graphene nanocomposites by a facile hydrothermal treatment using an inorganic titanium source and highly-conductive, low-defective amphiphilic graphene sheets prepared by a microwave-enabled dispersion approach developed by our group. The structures and composition of the flower shaped composite particles and sheets were characterized by scanning electron microscope (SEM), Raman, and ultraviolet visible spectroscopy (UV-Vis), etc. The efficiency enhancement for photocatalytic reduction of CO2 and photocatalytic oxidation of pharmaceutical drug waste in the environment will be examined in future studies.
Triviidae Troschel 1863
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Triviidae

description: Family Triviidae
Proterato rehderi Raines, 2002 (Figure 30); one paratype.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Epitoniidae S.S.Berry 1910
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Epitoniidae

description: Family Epitoniidae
Epitonium leali García, 2011 (Figure 31); one paratype.
Epitonium pigrum García, 2011 (Figure 32); one paratype.
Scalina billeeana DuShane & Bratcher, 1965 (Figure 33); one paratype.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Inventaire du fonds Bastaire de littérature populaire et infantine [version 1]. Le livre national (collection rouge) (et romans de cape et d'épée) (Tallandier) (Tallandier)
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Numérisation ICB CollEx-Persée AAP20212022
description: Les titres sont ceux donnés par Jean Bastaire. Les dates indiquées ont été établies depuis un courrier de Jean à Michel Bastaire qui lui demandait de dresser l'inventaire. Et la date de fin correspond à la donation et à la publication de Lectures englouties. Listes manuscrites de la collection établie par Jean Bastaire et Michel Bastaire ; Jean sous forme de livrets thématiques et feuilles volantes au format A5. Michel a consigné les titres dans un carnet bloc type Rhodia format A6.
description: Source: Fonds Bastaire Université Clermont Auvergne (Bas-G08_D013)
description: Relation: http://www.calames.abes.fr/pub/ms/_631139801_Bas-G08_D013
description: created: 1993/2008
Cerithiopsidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Cerithiopsidae

description: Family Cerithiopsidae
Cerithiopsis krisbergi Rolán & Fernández-Garcés, 2007 (Figure 34); one paratype.
Cerithiopsis susieae Rolán & Krisberg, 2014 (Figure 35); one paratype.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 6, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Notocythere antichthon Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Notocythere
Notocythere antichthon

description: Notocythere antichthon Hart & Hart, 1967
1967b Notocythere antichthon sp. nov. —Hart & Hart: 9, 16–17, 18, 22, 38, 39, Figs. 36–37 (A, D, H, K, R, T).
1974 Notocythere antichthon Hart and Hart, 1967.—Hart & Hart: 146, 157, 158, 217, 236, Pl. XLI Figs. 11–12, Pl. LX (D, H, K, R, T).
1975 Notocythere antichthon Hart & Hart, 1967.—Hart & Hart: 58 (C, D, H).
2014a Notocythere antichthon Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 951 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 103, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Hyssopus nigritulus Zetterstedt
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hyssopus
Hyssopus nigritulus

description: 50. Hyssopus nigritulus (Zetterstedt)
Material examined. 22 ♀, Israel, Emeq Bet She’an, reared from Zeuzera pyrina on Olea sp., 1992 (D. Gerling); 2 ♀, Tel Aviv, M.T., 23.vi.2007 (W. Kuslitzky); 2 ♀, Ma’agan Mikha’el, M.T., 29.ii.2008 (W. Kuslitzky); 1 ♀, Ma’agan Mikha’el, M.T., xi.2008 (W. Kuslitzky); 1 ♀, Ma’agan Mikha’el, M.T., 5.iii.2009 (W. Kuslitzky); 3 ♀, Tel Aviv, M.T., 15.iv.2007 (W. Kuslitzky); 1 ♂, Ashdod, sweeping, 14.x.1971 (D. Gerling); 1 ♀, Tel Aviv, M.T., 23.v.2007 (W. Kuslitzky); 1 ♀, Mt. Carmel, Nahal Oren, sweeping, 1.iv.2010 (Z. Yefremova); 2 ♀, ‘En Perat, M.T., 28.xi.2011 (Z. Yefremova, V. Kravchenko).
Hosts. Ectoparasitoid of Tortricidae and Cosmopterigidae (Lepidoptera) (Bouček & Askew 1968); new host - record Z. pyrina (L.) on Olea sp.
Distribution. Israel *; Palearctic (Bouček & Askew 1968).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 13, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Notocythere blundelli Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Notocythere
Notocythere blundelli

description: Notocythere blundelli Hart & Hart, 1967
1967b Notocythere blundelli sp. nov. —Hart & Hart: 9, 14, 17–18, 23, 40, 41, Figs. 38–41 (A, D, H, K, R, T).
1974 Notocythere blundelli Hart and Hart, 1967.—Hart & Hart: 146, 157, 217, 236, Pl. XLI Figs. 13–16, Pl. LX (D, H, K, R, T).
1975 Notocythere blundelli Hart & Hart, 1967.—Hart & Hart: 58–59 (C, D, H).
2014a Notocythere blundelli Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 951 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 103, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
A Candidate Breast Tumor Suppressor Gene on Chromosome 13
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the fundamental goals in breast cancer research is to identify genes that are involved in the origin and progression of cancer. One group of cancer-related genes are tumor suppressor genes (TSG) that normally function to prevent or suppress tumors. When the TSG is mutated or lost and its function is lacking, tumors are then capable of unimpeded growth and proliferation. We have isolated a candidate gene (designated Brush-1) that is located on chromosome 13 in a region of frequent genetic instability in breast tumors. The Brush-1 gene's function is lost in more than one third of primary breast tumors and about half of breast cancer cell lines tested. Furthermore, the loss of Brush-1 function occurs specifically in those breast tumors carrying the chromosome 13 genetic anomaly. This differential loss of Brush-1 function for both primary tumors and breast cancer cell lines is the expected pattern for a breast TSG. We will show a role for the normal Brush-1 gene in suppressing breast tumors by inserting a normal Brush-1 gene directly into breast cancer cells lacking Brush-1 function. We will then examine the effect of restoring Brush-1 function in these breast cancer cells. We will characterize these genetically modified cells for a number of cancer properties including high growth rate and motility and also the ability to invade other tissues and form tumors. Loss or reduction of tumor-related properties will support a key role for Brush-1 in suppressing breast cancer. To further characterize Brush-1, we will determine the localization and patterns of Brush-1 gene function in normal and tumor tissues.

 The proposed characterization of Brush-1 is a necessary first step toward an understanding of the processes involved in breast cancer. Besides serving as an important new genetic marker for breast cancer, the replacement of normal Brush-1 function may prove to be an important strategy in the prevention of a significant proportion of breast cancers.
The medicinal phage-regulatory roadmap for phage therapy under EU pharmaceutical legislation
Creators: name: Faltus, Timo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 349

description: Bacteriophage therapy is a promising approach to treating bacterial infections. Research and development of bacteriophage therapy is intensifying due to the increase in antibiotic resistance and the faltering development of new antibiotics. Bacteriophage therapy uses bacteriophages (phages), i.e., prokaryotic viruses, to specifically target and kill pathogenic bacteria. The legal handling of this type of therapy raises several questions. These include whether phage therapeutics belong to a specially regulated class of medicinal products, and which legal framework should be followed with regard to the various technical ways in which phage therapeutics can be manufactured and administered. The article shows to which class of medicinal products phage therapeutics from wild type phages and from genetically modified (designer) phages do or do not belong. Furthermore, the article explains which legal framework is relevant for the manufacture and administration of phage therapeutics, which are manufactured in advance in a uniform, patient-independent manner, and for tailor-made patient-specific phage therapeutics. For the systematically coherent, successful translation of phage therapy, the article considers pharmaceutical law and related legal areas, such as genetic engineering law. Finally, the article shows how the planned legislative revisions of Directive 2001/83/EC and Regulation (EC) No 726/2004 may affect the legal future of phage therapy.
Microlycus erdoesi Boucek
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Microlycus
Microlycus erdoesi

description: 51. Microlycus erdoesi Bouček
Material examined. 1 ♀, Israel, Ma’agan Mikha’el, M.T., 29.iv.2009 (W. Kuslitzky); 1 ♀, Ma’agan Mikha’el, M.T., 22.iv.2009 (W. Kuslitzky); 1 ♀, Almagor, M.T., 9.xii.2010 (W. Kuslitzky). Hosts. Unknown.
Distribution. Israel *; Palearctic (Yefremova 2002).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 13, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Cell Microenvironment and Progression of Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Progression of breast cancer from benign cells to a life-threatening disease is characterized by acquisition of migratory and invasive properties of tumor cells as they move through the breast tissue in search of blood vessels. It is this process and the subsequent infiltration of blood vessels and colonization of other organs which constitutes metastasis. From our own past and ongoing research, and from published reports, we have concluded that a major factor in tumor progression is the interaction of tumor cells with their surrounding microenvironment. This microenvironment consists of stroma, cells that create a supporting framework which is often composed of connective tissue for a gland or organ, and extracellular matrix (ECM), the interwoven network of proteins which provides additional support and vital information to surrounding cells.

 It is known that for normal functioning, cells require the surrounding structure of the ECM. Although attempts have been made to understand the interaction of the cell with its microenvironment, the lack of suitable tissue culture models has hampered the precise interpretation of the data obtained and raised questions about their physiological relevance. We have now begun to reconstitute the cellular and ECM microenvironment of tumor cells in three dimensions by taking into culture a cell line which recapitulates the different stages of tumor progression. With this designer microenvironment in hand, we are able to analyze the role of tumor cell-stroma interactions and molecules of the ECM in tumor progression and to test our hypotheses by experimental manipulation. In our investigation, we will focus on a class of matrix-degrading enzymes, metalloproteinases, which are frequently found in large amounts in breast tumors, and are believed to promote tumor cell invasion by breaking down the components of ECM.

 The proposed study is expected to enable a better understanding of the development of breast cancer and to identify molecular changes associated with the early stages of tumor progression in the breast. Detection of these changes in tumor patients would thus provide a valuable tool for the diagnosis of breast cancer. Furthermore and foremost, we expect to identify those molecules which are indispensable for tumor migration and invasion. By interfering with their function we hope to block tumor progression. We will also search for signals inside the ECM which attenuate or abolish tumor progression. Upon identification of these inhibitory signals we will engineer small peptides (chains of amino acids) which can be administered to breast tissues and block tumor progression.
Tree and mycorrhizal fungal diversity drive intraspecific and intraindividual trait variation in temperate forests: Evidence from a tree diversity experiment
Creators: name: Castro Sánchez-Bermejo, Pablo
name: Monjau, Tilo
name: Goldmann, Kezia
name: Ferlian, Olga
name: Eisenhauer, Nico
name: Bruelheide, Helge
name: Ma, Zeqing
name: Haider, Sylvia Simone Rebekka
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 580

description: The study of tree species coexistence is crucial to understand the assembly of forest communities. In this context, trees adjust their traits in response to the interactions with other trees and, specifically, as a result of the competition for resources. Further, mycorrhizal fungal diversity and associations are important drivers of ecosystem functioning in forests, but their role as drivers of intraspecific trait variation has been disregarded. Here, we studied intraspecific trait variation of trees in response to tree and mycorrhizal fungal diversity. We sampled 3200 leaves from 640 trees belonging to 10 native, deciduous species in a tree diversity experiment in Central Germany. This experiment relies on the combination of gradients of tree richness and mycorrhizal associations. To handle large amounts of leaf samples, we acquired leaf-level spectral data and used deep learning to predict values for five leaf traits from the leaf economics spectrum (LES): specific leaf area, leaf dry matter content, carbon to nitrogen ratio, carbon content and phosphorus content. For every tree, we calculated the mean value for every trait and two multi-trait functional indices (functional richness and functional dispersion) based on values for individual leaves. Finally, we used sequencing-based data to assess the richness of mycorrhizal fungi associated with the trees. We found that tree and mycorrhizal fungi richness had an effect on different leaf functional traits. Specifically, tree richness positively affected specific leaf area and, additionally, had a negative effect on the functional indicies, which revealed that the phenotypic diversity within the tree crown decreased with tree species richness. In addition, leaf carbon to nitrogen ratio decreased with increasing arbuscular mycorrhizal fungal richness in both arbuscular and ectomycorrhizal tree species. Finally, we did not find differences between arbuscular and ectomycorrhizal trees regarding their location within the LES. Our results suggest that trees modify their strategy in response to local tree diversity, not only by shifting trait values but also by shifting the variability intraindividually. In addition, higher mycorrhizal fungal diversity does not seem to lead to higher complementarity, but instead, tree and mycorrhizal fungi affect different aspects of leaf traits.
Peptide Vaccines for Immunoprevention of Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project will examine how the immune system can be used to prevent recurrent breast cancer. About a third of all women with breast cancer have breast tumor cells that make a large amount of a particular protein, called erbB-2. Because of this, these tumor cells can be distinguished immunologically from normal cells. We aim to take advantage of this distinctive feature of breast cancer cells to develop a novel strategy to treat those patients who have tumors that make large amounts of the erbB-2 protein. Our research will investigate ways to induce an immune response against this protein in such patients. Such an immune response should destroy tumor cells that make erbB-2, and thereby protect such patients from developing recurrent breast cancer.

 We propose to study synthetic peptide vaccines that can stimulate an immune response against cells that overproduce erbB-2. Because erbB-2 is a ‘self protein’, it ordinarily does not stimulate an immune response. However, synthetic peptides that mimic portions of the erbB-2 protein can induce an immune response against erbB-2, particularly when such peptides are physically coupled to an immunogenic protein or presented by activated immune cells that can initiate the immune response. The immune response induced by these synthetic peptides can result in the production of antibodies that bind erbB-2. Alternatively, they may activate "helper T cells" that can induce cytotoxic T cells and/or macrophages that specifically can kill tumor cells. We have identified candidate synthetic peptides that can induce such responses and have developed methods for identifying additional synthetic peptides for use as vaccines against recurrent breast cancer.

 We plan to: 1) characterize the antibodies induced by synthetic peptides of erbB-2 for their ability to affect adversely the growth or survival of breast tumor cells; 2) identify synthetic peptides of erbB-2 that can be presented to, and recognized by, helper T cells; and 3) examine peptide vaccines for their ability to prevent breast cancer recurrence. Through these studies we may discover effective strategies for the active immune prevention of recurrent breast cancer.