Vitamin C Mitigating and Rescuing from Synergistic Toxicity: Sodium Fluoride, Silicofluorides, Aluminum Salts, Electromagnetic Pollution, and SARS-CoV-2
Creators: name: Davidson, Robert M.
name: Winey, Timothy
Publisher: name: figshare
Year: 2021
Subjects: subject: 111602 Human Biophysics
subject: FOS: Basic medicine
subject: 110707 Innate Immunity
subject: FOS: Clinical medicine
subject: 110799 Immunology not elsewhere classified
subject: 110199 Medical Biochemistry and Metabolomics not elsewhere classified
subject: 110101 Medical Biochemistry: Amino Acids and Metabolites
subject: 110105 Medical Biochemistry: Nucleic Acids
subject: 110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
subject: 110802 Medical Infection Agents (incl. Prions)
subject: FOS: Health sciences
subject: 110899 Medical Microbiology not elsewhere classified
subject: 111699 Medical Physiology not elsewhere classified
subject: 110804 Medical Virology
subject: 110107 Metabolic Medicine
subject: 111207 Molecular Targets
subject: 111716 Preventive Medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 111104 Public Nutrition Intervention
subject: 111404 Reproduction
subject: FOS: Medical biotechnology
subject: 110203 Respiratory Diseases
subject: 111603 Systems Physiology
subject: 110705 Humoural Immunology and Immunochemistry
subject: 111712 Health Promotion
subject: 111706 Epidemiology
subject: Diseases
subject: 110305 Emergency Medicine
subject: 110499 Complementary and Alternative Medicine not elsewhere classified
subject: 110399 Clinical Sciences not elsewhere classified
subject: 110303 Clinical Microbiology
subject: 110302 Clinical Chemistry (diagnostics)
subject: 110704 Cellular Immunology
subject: 111601 Cell Physiology
subject: 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified
subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: 111201 Cancer Cell Biology
subject: 110703 Autoimmunity
subject: 110701 Allergy
subject: 111702 Aged Health Care

description: A supramolecular paradigm for mitigation and rescue from SARS-COV2 infection is proposed. Similarities between the Sanarelli-Shwartzman phenomenon and biological responses to viral pathogens are considered. Non-enzymatic group transfer catalysis (NGTC) by L-ascorbic acid, the L-ascorbic acid free radical and the 2-O-phosphate substituted L-ascorbic acid derivative are proposed under the ascorbolysis hypothesis to provide a supramolecular basis for mitigating the synergistic toxicity and catalytic mimicry by the environmental toxicants, sodium fluoride, aluminum salts, and silicofluorides in public water supplies. Ascorbolysis is the term we adopt to describe a redox active, hyperconjugated, vinylogous variant of acidolysis. The objective of this paper is to provide a plausible supramolecular basis for mitigation and rescue from well-known environmental toxicity represented by the presence of sodium fluoride, aluminum salts, and silicofluoride species in public water supplies. An overview of the conceptual basis for NGTC by vitamin C during inflammatory states is provided. Controversies concerning the initial oxidation steps and pH-dependent speciation of L-ascorbic acid are addressed. Non-skeletal fluorosis is a serious systemic malady which we propose arises from disruption of hydrogen bond networks and hydrogen bond cooperativity resulting from the marked electronegativity and hydrogen bond accepting ability of fluoride atoms found in NaF and AlFx species. AlFx species have been previously shown to arise in situ spontaneously from NaF, aluminum salts, and silicofluorides often found in toothpastes and “fluoridated” drinking water. AlFx species are thought to act as isosteric mimics of biophosphates during group transfers of phosphoryl moieties. We propose that catalytic mimicry by AlFx species inhibits postulated non-enzymatic kinase-like and RNA polymerase-like function of the AA-2P derivative during inflammatory states. We describe how NGTC by L-ascorbic acid is likely to be disrupted by AlFx and sodium fluoride of a specific H3-O2 intramolecular hydrogen bond in L-ascorbic acid, the L-ascorbic acid free radical, and their 2-O-substituted derivatives, which are necessary for NGTC in the moderately acidic, mildly oxidative, relatively hydrophobic microenvironment which typify inflammatory states. Suggestions are made to achieve less variation in results of large randomized clinical trials (RCTs) seeking to validate use of high-dose intravenous vitamin C in critical care and cancer settings.