Additional file 1 of Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU
Creators: name: Fuest, Kristina E.
name: Ulm, Bernhard
name: Daum, Nils
name: Lindholz, Maximilian
name: Lorenz, Marco
name: Blobner, Kilian
name: Langer, Nadine
name: Hodgson, Carol
name: Herridge, Margaret
name: Blobner, Manfred
name: Schaller, Stefan J.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Mathematical Sciences not elsewhere classified

description: Additional file 1. Figure S1: Elbow method for determination of clusters. Figure S2: Euclidian distance plot. Heatmap showing Euclidean distances between samples clustered using complete linkage. Factors used for Cluster Analysis are visualized as column annotations. Table S1: Patient Characteristics. Numbers are presented as n (%) or median [IQR]. “Frail” is defined as Clinical Frailty Scale 5–9. A p-value of &lt; 0.05 was considered significant. ICU Intensive Care Unit, IQR Interquartile Range, APACHE II Acute Physiology and Chronic Health Evaluation Score, SOFA Sepsis-related Organ Failure Assessment Score, MTB Mobility-Transfer-Barthel. Table S2: Post-hoc Analyses of patient characteristics in the four clusters. Numbers are presented as n (%) or median [IQR]. “Frail” is defined as Clinical Frailty Scale 5–9. A p-value of &lt; 0.05 was considered significant. APACHE Acute Physiology and Chronic Health Evaluation Score, SOFA Sepsis-related Organ Failure Assessment Score, MTB Mobility-Transfer-Barthel. Table S3: Post-hoc Analyses of mobilization characteristics in the four clusters. Early mobilization is defined as mobilization within 72h of ICU admission. A p-value of &lt; 0.05 was considered significant. Numbers are presented as n (%) or median [IQR]. IQR Interquartile Range, SOMS Surgical Intensive Care Unit Optimal Mobilization Score. Table S4: Stepwise Regression Models. “Frailty” is defined as Clinical Frailty Scale 5–9. A p-value of &lt; 0.05 was considered significant. Early mobilization is defined as mobilization within 72h of ICU admission. OR Odds Ratio, CI Confidence interval, ICU Intensive Care Unit, IQR Interquartile Range, APACHE II Acute Physiology and Chronic Health Evaluation Score, SOFA Sepsisrelated Organ Failure Assessment Score, SOMS Surgical Intensive Care Unit Optimal Mobilization Score. Table S5: Logistic regression models of survivors of hospital stay. Early mobilization is defined as mobilization within 72h of ICU admission. A p-value of &lt; 0.05 was considered significant. OR Odds Ratio, CI Confidence interval, SOMS Surgical Intensive Care Unit Optimal Mobilization Score. a Model was corrected for postoperative care, frailty, department. b Model was corrected for Sepsis-related Organ Failure Assessment Score, body mass index (categories), postoperative, frailty, other admission reasons, admission, and non-traumatic brain injury. c Model was corrected for department and Glasgow Coma Scale. d Model was corrected for APACHE II, department, admission, Mobility-Transfer-Barthel Score at hospital admission and age (categories). Table S6: Sensitivity Analysis with the ICU Mobility Scale. Early mobilization is defined as mobilization within 72h of ICU admission. A p-value of &lt; 0.05 was considered significant. OR Odds Ratio, CI Confidence interval. IQR Interquartile Range, IMS ICU Mobility Scale. Table S7: Secondary Endpoints. Secondary endpoints in dependence of the four clusters. Here, the results of the primary analysis as well as the post-hoc analyses are listed. Numbers are presented as n (%) or median [IQR]. A p-value of &lt; 0.05 was considered significant. IQR Interquartile Range, ICU Intensive Care Unit.