cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Understanding the early stage of cluster formation
Creators: name: Shi, Ke
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: High energy astrophysics and galactic cosmic rays
Astroparticle physics and particle cosmology
Cosmology and extragalactic astronomy

description: Understanding the formation and evolution of galaxies is a crucially important task in modern astronomy. It is well known that galaxy formation is strongly affected by the environments they reside in. Galaxy clusters, as the densest large-scale structures in the Universe, thus serve as ideal laboratories to study how galaxy formation proceeds in dense environments. Clusters already began to form at $z>2$, therefore to directly witness the early stage of galaxy formation in dense environments, it is necessary to identify progenitors of clusters (`protoclusters') and study their galaxy constituents within. In this thesis, I present two observational studies on high-redshift protoclusters at $z>3$. Utilizing multiwavelength data and different galaxy selection techniques, significant galaxy overdensities are found in the two protoclusters, which are predicted to evolve into Coma-like clusters by present day. Various types of galaxies are identified in the protocluster, such as normal star-forming galaxies, massive quiescent galaxies and post-starburst galaxies. Together with extreme and rare sources such as giant Lyman-alpha nebulae and brighest cluster galaxy, they paint a picture of how different galaxy populations trace the underlying dark matter halos. Finally, the environmental impact on galaxy properties appears to be a subtle one for these protoclusters, which might depend on the galaxy population one chooses to study.
Additional file 1 of Optimizing organically nano-fabricated Ni metal complexes for enhanced antioxidant and anticancer activity using response surface methodology
Creators: name: Aleti, Swathi
name: Belwal, Savita
name: Medala, Mukunda Vani
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Four tables of statistical data are being provided for Anti-cancer studies.
Supplemental Material, sj-pdf-2-jic-10.1177_08850666211032175 - The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients
Creators: name: Ritter, Lindsay A.
name: Britton, Noel
name: Heil, Emily L.
name: Teeter, William A.
name: Murthi, Sarah B.
name: Chow, Jonathan H.
name: Ricotta, Emily
name: Chertow, Daniel S.
name: Grazioli, Alison
name: Levine, Andrea R.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental Material, sj-pdf-2-jic-10.1177_08850666211032175 for The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients by Lindsay A. Ritter, Noel Britton, Emily L. Heil, William A. Teeter, Sarah B. Murthi, Jonathan H. Chow, Emily Ricotta, Daniel S. Chertow, Alison Grazioli and Andrea R. Levine in Journal of Intensive Care Medicine
Additional file 4 of A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery
Creators: name: Kaeslin, Rahel
name: Latal, Beatrice
name: Mitteregger, Elena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Additional file 4. PRISMA 2020 checklist.
Impfungen von Kindern und Jugendlichen auch gegen den Elternwillen? - Ein Diskussionsbeitrag zu ärztlichen Aufgaben und rechtlichen Rahmenbedingungen
Creators: name: Nassauer, Alfred
name: Meyer, Christiane
Publisher: name: Robert Koch-Institut
Year: 2004
Subjects: subject: Impfung
subject: 610 Medizin

description: Berichte über Todesfälle oder bleibende Gesundheitsschäden nach impfpräventablen Erkrankungen sind in Deutschland ob der in Teilen doch zufrieden stellenden Durchimpfungsraten eine Seltenheit. Das Grundgesetz garantiert den Eltern das weitgehende, von staatlichen Einflüssen ausgenommene Recht, für das Wohl der Kinder zu sorgen. Der Staat hat im Rahmen seines Wächteramtes bei der Ausgestaltung dieses Rechtes lediglich eine koordinierende Funktion. Dies führt zur Frage, ob Kinder ein eigenes, ethisch und/oder gesetzlich begründetes Recht auf Schutzimpfungen haben. Ein solches lässt sich aus der UN-Kinderrechtskonvention, dem individuellen Recht auf Gesundheit und der Tatsache ableiten, dass Kinder und Jugendliche jeden Alters Träger dieser Grundrechte sind und sie bei der erforderlichen Einsichtsfähigkeit und Reife auch selbst wahrnehmen können. Regelungen zu Schutzimpfungen im Infektionsschutzgesetz (IfSG) nehmen Gesundheitsämter bzgl. der Information der Öffentlichkeit besonders in die Pflicht. Nur nach ihren individuellen Bedürfnissen entsprechend aufgeklärte Eltern sind in der Lage, sich bewusst für oder gegen Schutzimpfungen zu entscheiden. Aufgrund ihrer Garantenstellung obliegt aber auch impfenden Ärzten eine umfassende Hinweispflicht zu den genannten Präventionsmaßnahmen. Nach der epidemiologischen Situation fällt es schwer, Schutzimpfungen als dringliche medizinische Maßnahme zu begründen und bei einer entsprechenden Weigerung durch Eltern oder andere Sorgeberechtigte Ärzten aufzuerlegen, in solchen Fällen Jugendämter oder Familiengerichte einzuschalten, damit diese ggf. die Einwilligung zur Impfung erteilen. Die Postulierung einer solchen Pflicht wäre einem vertrauensvollen Arzt-Patienten-Verhältnis derart abträglich, dass sie aus ethischen Gründen nicht ernsthaft gefordert werden kann. Gemäß § 20 Abs. 6 und 7 IfSG können Schutzimpfungen durch Rechtsverordnung angeordnet werden. Diese Möglichkeit sollte für die Fälle bedacht und erneut diskutiert werden, in denen Kinder Gemeinschaftseinrichtungen besuchen und die individuelle Freiheit (auch als Freiheit der Eltern) gegenüber der Sozialbindung von Grundrechten zurücktreten muss.
Additional file 1 of A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery
Creators: name: Kaeslin, Rahel
name: Latal, Beatrice
name: Mitteregger, Elena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Additional file 1. Initial search strategy.
A study of the prediction performance and multivariate extensions of the horseshoe estimator
Creators: name: Li, Yunfan
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Statistics not elsewhere classified

description: The horseshoe prior has been shown to successfully handle high-dimensional sparse estimation problems. It both adapts to sparsity efficiently and provides nearly unbiased estimates for large signals. In addition, efficient sampling algorithms have been developed and successively applied to a vast array of high-dimensional sparse estimation problems. In this dissertation, we investigate the prediction performance of the horseshoe prior in sparse regression, and extend the horseshoe prior to two multivariate settings.

We begin with a study of the finite sample prediction performance of shrinkage regression methods, where the risk can be unbiasedly estimated using Stein's approach. We show that the horseshoe prior achieves an improved prediction risk over global shrinkage rules, by using a component-specific local shrinkage term that is learned from the data under a heavy-tailed prior, in combination with a global term providing shrinkage towards zero. We demonstrate improved prediction performance in a simulation study and in a pharmacogenomics data set, confirming our theoretical findings.

We then shift to extending the horseshoe prior to handle two high-dimensional multivariate problems. First, we develop a new estimator of the inverse covariance matrix for high-dimensional multivariate normal data. The proposed graphical horseshoe estimator has attractive properties compared to other popular estimators. The most prominent benefit is that when the true inverse covariance matrix is sparse, the graphical horseshoe estimator provides estimates with small information divergence from the sampling model. The posterior mean under the graphical horseshoe prior can also be almost unbiased under certain conditions. In addition to these theoretical results, we provide a full Gibbs sampler for implementation. The graphical horseshoe estimator compares favorably to existing techniques in simulations and in a human gene network data analysis.

In our second setting, we apply the horseshoe prior to the joint estimation of regression coefficients and the inverse covariance matrix in normal models. The computational challenge in this problem is due to the dimensionality of the parameter space that routinely exceeds the sample size. We show that the advantages of the horseshoe prior in estimating a mean vector, or an inverse covariance matrix, separately are also present when addressing both simultaneously. We propose a full Bayesian treatment, with a sampling algorithm that is linear in the number of predictors. Extensive performance comparisons are provided with both frequentist and Bayesian alternatives, and both estimation and prediction performances are verified on a genomic data set.
Additional file 1 of Antimicrobial resistance and heterogeneity of Neisseria gonorrhoeae isolated from patients attending sexually transmitted infection clinics in Lusaka, Zambia
Creators: name: Sarenje, Kelvin Lutambo
name: van Zwetselaar, Marco
name: Kumburu, Happiness
name: Sonda, Tolbert
name: Mmbaga, Blandina
name: Ngalamika, Owen
name: Maimbolwa, Margaret C.
name: Siame, Amon
name: Munsaka, Sody
name: Kwenda, Geoffrey
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
TARGETED DELIVERY OF DASATINIB FOR ACCELERATED BONE FRACTURE REPAIR
Creators: name: Wang, Mingding
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Biochemistry and cell biology not elsewhere classified
Organic chemistry not elsewhere classified
Medicinal and biomolecular chemistry not elsewhere classified

description: Approximately 6.3 million bone fractures occur annually in the USA, resulting in considerable morbidity, deterioration in quality of life, loss of productivity and wages, and sometimes death (e.g. hip fractures). Although anabolic and antiresorptive agents have been introduced for treatment of osteoporosis, no systemically-administered drug has been developed to accelerate the fracture healing process. To address this need, we have undertaken to target a bone anabolic agent selectively to fracture surfaces in order to concentrate the drug’s healing power directly on the fracture site. We report here that conjugation of dasatinib to a bone fracture-homing oligopeptide via a releasable linker reduces fractured femur healing times in mice by ~60% without causing overt off-target toxicity or remodeling of nontraumatized bones. Thus, achievement of healthy bone density, normal bone volume, and healthy bone mechanical properties at the fracture site is realized after only 3-4 weeks in dasatinib-targeted mice, but requires ~8 weeks in PBS-treated controls. Moreover, optimizations have been implemented to the dosing regimen and releasing mechanisms of this targeted-dasatinib therapy, which has enabled us to cut the total doses by half, reduce the risk of premature release in circulation, and still improve upon the therapeutic efficacy. These efforts might reduce the burden associated with frequent doses on patients with broken bones and lower potential toxicity brought by drug degradation in the blood stream. In addition to dasatinib, a few other small molecules have also been targeted to fracture surfaces and identified as prospective therapeutic agents for the acceleration of fracture repair. In conclusion, in this dissertation, we have successfully targeted dasatinib to bone fracture surfaces, which can significantly accelerate the healing process at dasatinib concentrations that are known to be safe in oncological applications. A modular synthetic method has also been developed to allow for easy conversion of a bone-anabolic warhead into a fracture-targeted version for improved fracture repair.
Alcuni appunti sul condizionale in italiano
Creators: name: Ardolino, Francesco
Publisher: name: Humanities Commons
Year: 1998
Subjects: subject: Linguistics
subject: FOS: Languages and literature
subject: Italian language

description: The aim of this article is that of clarifying those issues of the analysis of the conditional structures in Italian which are more difficult to pin down. Once their «double nature» (temporal and modal) is established, attention is switched to the most conflicting aspects shown by the conditional structures («mixed» hypothetical periods, reported speech conditional, their liability to be substituted by a past tense, etc.) and the basis for a future stylistic analysis, of a more systematic kind, is put forward.
Clostridium-difficile-Ribotyp 027: Epidemiologie und Klinik des erstmaligen endemischen Auftretens in Deutschland
Creators: name: Jansen, Andreas
name: Kleinkauf, Niels
name: Weiß, B.
name: Zaiß, Henning
name: Witte, Wolfgang
name: Bornhofen, Bernhard
name: Kist, Manfred
name: Eichel-Streiber, C. Von
name: Neumann, M.
name: Michels, H.
name: Eckmanns, Tim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger; Robert Koch-Institut, Infektionsepidemiologie
Year: 2010
Subjects: subject: infektiöse Kolitis
subject: Darm
subject: pseudomembranöse Kolitis
subject: 610 Medizin

description: Hintergrund: Im September 2007 trat eine Häufung von ungewöhnlich schwer verlaufenden Clostridium-difficile-assoziierten Infektionen (CDI) in einem Trierer Krankenhaus auf. Es wurde vermutet, dass ein neuer Stamm (PCR-Ribotyp 027) mit diesen Ereignissen im Zusammenhang stehen könnte. Zur Untersuchung der Erkrankungsfälle wurde das Gesundheitsamt Trier auf Einladung des Landes Rheinland-Pfalz von einem Feldteam des Robert Koch-Instituts unterstützt. Ziel der Untersuchung war die Aufklärung und Unterbrechung der vermuteten Infektkette. Methoden: Neben einer retrospektiven Fallsuche von schwer verlaufenden CDI durch Analyse von Patientenakten und Totenscheinen erfolgte eine intensivierte Surveillance von schweren CDI in den Krankenhäusern der betroffenen Region. Dazu wurden bei allen neu auftretenden Verdachtsfällen parallel ein Toxin-A/B-Nachweis und eine selektive Anzucht auf C. difficile durchgeführt. Die Isolate wurden mittels PCR ribotypisiert. Daten zum Krankheitsverlauf und zur Letalität wurden mit einem standardisierten Erhebungsbogen erfasst und statistisch in einer multivariaten Analyse ausgewertet. In dem Index-Krankenhaus wurden Personaluntersuchungen durchgeführt. Ergebnisse: Bis zum 31.1.2008 wurden insgesamt 27 schwere CDI ohne Ribotypisierung und 21 bestätigte Fälle von C.-difficile-Ribotyp-027-Infektionen der Region Trier identifiziert. Im Rahmen der intensivierten Surveillance wurden 399 Patienten untersucht, von denen 76 (19 %) C.-difficile-Isolate angezüchtet werden konnten. Bei 20 Patienten wurde der PCR-Ribotyp 027 nachgewiesen. Insgesamt kam es zu 9 Todesfällen (19 %). Eine bestehende immunsupressive Therapie (Odds Ratio 35,8; 95 %-Konfidenzintervall 2,8 - 464,5) war unabhängiger Risikofaktor für einen letalen Krankheitsverlauf. Schwer verlaufende Infektionen wurden auch bei anderen, Nicht-027-Ribotypen beobachtet. Im Screening vom Krankenhauspersonal des Indexkrankenhauses (n = 161) waren 6 % der Mitarbeiter C.-difficile-Toxin positiv. Diskussion: In dieser Untersuchung konnte erstmalig die endemische Verbreitung von C.-difficile-PCR-Ribotyps 027 in einer Region Deutschlands nachgewiesen werden. Als direkte Konsequenz des Ausbruchs wurde Ende 2007 die Ärztliche Meldepflicht für schwer verlaufende CDI eingeführt. Neben krankenhaushygienischen Maßnahmen ist die kritische Verwendung von Antibiotika eine wichtige Maßnahme zur Verhinderung einer weiteren Zunahme von CDI.
Nonlinear Growth and Breakdown of the Hypersonic Crossflow Instability
Creators: name: Edelman, Joshua B
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Hypersonic propulsion and hypersonic aerothermodynamics

description: A sharp, circular 7° half-angle cone was tested in the Boeing/AFOSR Mach-6 Quiet Tunnelat 6° angle of attack, extending several previous experiments on the growth and breakdown ofstationary crossflow instabilities in the boundary layer.
Measurements were made using infraredimaging and surface pressure sensors. Detailed measurements of the stationary and travelingcrossflow vortices, as well as various secondary instability modes, were collected over a largeregion of the cone.
The Rod Insertion Method (RIM) roughness, first developed for use on a flared cone, wasadapted for application to crossflow work. It was demonstrated that the roughness elements werethe primary factor responsible for the appearance of the specific pattern of stationary streaksdownstream, which are the footprints of the stationary crossflow vortices. In addition, a roughnessinsert was created with a high RMS level of normally-distributed roughness to excite the naturallymost-amplified stationary mode.
The nonlinear breakdown mechanism induced by each type of roughness appears to bedifferent. When using the discrete RIM roughness, the dominant mechanism seems to be themodulated second mode, which is significantly destabilized by the large stationary vortices. Thisis consistent with recent computations. There is no evidence of the presence of traveling crossflowwhen using the RIM roughness, though surface measurements cannot provide a complete picture.The modulated second mode shows strong nonlinearity and harmonic development just priorto breakdown. In addition, pairs of hot streaks merge together within a constant azimuthalband, leading to a peak in the heating simultaneously with the peak amplitude of the measuredsecondary instability. The heating then decays before rising again to turbulent levels. This nonmonotonicheating pattern is reminiscent of experiments on a flared cone and earlier computationsof crossflow on an elliptic cone.
When using the distributed roughness there are several differences in the nonlinear breakdownbehavior. The hot streaks appear to be much more uniform and form at a higher wavenumber,which is expected given computational results. Furthermore, the traveling crossflow waves becomevery prominent in the surface pressure fluctuations and weakly nonlinear. In addition thereappears in the spectra a higher-frequency peak which is hypothesized to be a type-I secondary instabilityunder the upwelling of the stationary vortices. The traveling crossflow and the secondaryinstability interact nonlinearly prior to breakdown.
sj-pdf-1-pul-10.1177_20458940211029899 - Supplemental material for Quality of life in ambulatory pulmonary arterial hypertension in connective tissue diseases and its relationship with risk stratification
Creators: name: Shi, Yue
name: Meng, Yanling
name: Dong, Xingbei
name: Liu, Yang
name: Liu, Yongtai
name: Lai, Jinzhi
name: Tian, Zhuang
name: Zhao, Jiuliang
name: Peng, Jinmin
name: Wang, Qian
name: Li, Mengtao
name: Zeng, Xiaofeng
Publisher: name: SAGE Journals
Year: 2021
Subjects: Cardiology
Respiratory Diseases

description: Supplemental material, sj-pdf-1-pul-10.1177_20458940211029899 for Quality of life in ambulatory pulmonary arterial hypertension in connective tissue diseases and its relationship with risk stratification by Yue Shi, Yanling Meng, Xingbei Dong, Yang Liu, Yongtai Liu, Jinzhi Lai, Zhuang Tian, Jiuliang Zhao, Jinmin Peng, Qian Wang, Mengtao Li and Xiaofeng Zeng in Pulmonary Circulation
German-austrian recommendations for HIV1-therapy in pregnancy and in HIV1-exposed newborn - update 2008
Creators: name: Buchholz, Bernd
name: Beichert, Matthias
name: Marcus, Ulrich
name: Grubert, Thomas
name: Gingelmaier, Andrea
name: Haberl, Annette
name: Schmied, Brigitte
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: Pregnancy
subject: HIV-therapy
subject: HIV-status
subject: HIV-testing
subject: anti-retroviral drugs
subject: recommendations
subject: 610 Medizin

description: German-Austrian recommendations for HIV1-therapy in pregnancy - Update 2008 Bernd Buchholz (University Medical Centre Mannheim, Pediatric Clinic), Matthias Beichert (Mannheim, Gynecology and Obstetrics Practice), Ulrich Marcus (Robert Koch Institute, Berlin), Thomas Grubert, Andrea Gingelmaier (Gynecology Clinic of the Ludwig Maximilians University of Munich), Dr. med. Annette Haberl (HIV-Department, J. W. Goethe-University Hospital, Frankfurt), Dr. med. Brigitte Schmied (Otto-Wagner Spital, Wien). In Germany during the last years about 200-250 HIV1-infected pregnant women delivered a baby each year, a number that is currently increasing. To determine the HIV-status early in pregnancy voluntary HIV-testing of all pregnant women is recommended in Germany and Austria as part of prenatal care. In those cases, where HIV1-infection was known during pregnancy, since 1995 the rate of vertical transmission of HIV1 was reduced to 1-2%. This low transmission rate has been achieved by the combination of anti-retroviral therapy of pregnant women, caesarean section scheduled before onset of labour, anti-retroviral post exposition prophylaxis in the newborn and refraining from breast-feeding by the HIV1-infected mother. To keep pace with new results in research, approval of new anti-retroviral drugs and changes in the general treatment recommendations for HIV1-infected adults, in 1998, 2001, 2003 and 2005 an interdisciplinary consensus meeting was held. Gynaecologists, infectious disease specialists, paediatricians, pharmacologists, virologists and members of the German AIDS Hilfe (NGO) were participating in this conference to update the prevention strategies. A fifth update became necessary in 2008. The updating process was started in January 2008 and was terminated in September 2008. The guidelines provide new recommendations on the indication and the starting point for HIV-therapy in pregnancies without complications, drugs and drug combinations to be used preferably in these pregnancies and updated information on adverse effects of anti-retroviral drugs. Also the procedures for different scenarios and risk constellations in pregnancy have been specified again. With these current guidelines in Germany and Austria the low rate of vertical HIV1-transmission should be further maintained.
Additional file 2 of A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery
Creators: name: Kaeslin, Rahel
name: Latal, Beatrice
name: Mitteregger, Elena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Additional file 2. Update search strategy.
Architecting Query Compilers for Diverse Workloads
Creators: name: Tahboub, Ruby Y
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Applied computing not elsewhere classified
Software engineering not elsewhere classified

description: To leverage modern hardware platforms to their fullest, more and more database systems embrace compilation of query plans to native code. In the research community, there is an ongoing debate about the best way to architect such query compilers. This is perceived to be a difficult task, requiring techniques fundamentally different from traditional interpreted query execution. In this dissertation, we contribute to this discussion by drawing attention to an old but underappreciated idea known as Futamura projections, which fundamentally link interpreters and compilers. Guided by this idea, we demonstrate that efficient query compilation can actually be very simple, using techniques that are no more difficult than writing a query interpreter in a high-level language. We first develop LB2: a high-level query compiler implemented in this style that is competitive with the best compiled query engines both in sequential and parallel execution on the standard TPC-H benchmark.
Query engines process a variety of data types and structures including text, spatial, graphs, etc. Several spatial and graph engines are implemented as extensions to relational query engines to leverage optimized memory, storage, and evaluation. Still, the performance of these extensions is often stymied by the interpretive nature of the underlying data management, generic data structures, and the need to execute domain-specific external libraries. On that basis, compiling spatial and graph queries to native code is a desirable avenue to mitigate existing limitations and improve performance. To support compiling spatial queries, we extend the LB2 main-memory query compiler with spatial predicates, indexing structures, and spatial operators. To support compiling graph queries, we extend LB2 with graph data structures and operators. The spatial extension matches the performance of hand-written code and outperforms relational query engines and map-reduce extensions. Similarly, the graph extension matches, and sometimes outperforms, low-level graph engines.
Laboratory preparedness for detection and monitoring of Shiga toxin 2-producing Escherichia coli O104:H4 in Europe and response to the 2011 outbreak
Creators: name: Rosin, Polyia
name: Niskanen, T.
name: Palm, D.
name: Struelens, M.
name: Takkinen, J.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2013
Subjects: subject: Animals
subject: Humans
subject: Europe/epidemiology
subject: Disease Outbreaks
subject: Clinical Laboratory Techniques/methods
subject: Developing Countries
subject: Diarrhea/diagnosis
subject: Diarrhea/epidemiology
subject: Diarrhea/microbiology
subject: Escherichia coli/isolation & purification
subject: Escherichia coli Infections/diagnosis
subject: Escherichia coli Infections/epidemiology
subject: European Union/statistics & numerical data
subject: Feces/microbiology
subject: Shiga Toxin 2/isolation & purification
subject: Shiga-Toxigenic Escherichia coli/isolation & purification
subject: 610 Medizin

description: A hybrid strain of enteroaggregative and Shiga toxin 2-producing Escherichia coli (EAEC-STEC) serotype O104:H4 strain caused a large outbreak of haemolytic uraemic syndrome and bloody diarrhoea in 2011 in Europe. Two surveys were performed in the European Union (EU) and European Economic Area (EEA) countries to assess their laboratory capabilities to detect and characterise this previously uncommon STEC strain. Prior to the outbreak, 11 of the 32 countries in this survey had capacity at national reference laboratory (NRL) level for epidemic case confirmation according to the EU definition. During the outbreak, at primary diagnostic level, nine countries reported that clinical microbiology laboratories routinely used Shiga toxin detection assays suitable for diagnosis of infections with EAEC-STEC O104:H4, while 14 countries had NRL capacity to confirm epidemic cases. Six months after the outbreak, 22 countries reported NRL capacity to confirm such cases following initiatives taken by NRLs and the European Centre for Disease Prevention and Control (ECDC) Food- and Waterborne Disease and Zoonoses laboratory network. These data highlight the challenge of detection and confirmation of epidemic infections caused by atypical STEC strains and the benefits of coordinated EU laboratory networks to strengthen capabilities in response to a major outbreak.
Giardia duodenalis arginine deiminase modulates the phenotype and cytokine secretion of human dendritic cells by depletion of arginine and formation of ammonia
Creators: name: Banik, Stefanie
name: Viveros, Pablo Renner
name: Seeber, Frank
name: Klotz, Christian
name: Ignatius, Ralf
name: Aebischer, Toni
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2013
Subjects: subject: Humans
subject: Immunoglobulins/immunology
subject: Phenotype
subject: Ammonia/metabolism
subject: Antigens CD/immunology
subject: Antigens CD86/immunology
subject: Arginine/metabolism
subject: Dendritic Cells/immunology
subject: Dendritic Cells/parasitology
subject: Giardia lamblia/enzymology
subject: Giardia lamblia/immunology
subject: Giardia lamblia/pathogenicity
subject: Hydrolases/genetics
subject: Hydrolases/metabolism
subject: Interleukin-10/immunology
subject: Interleukin-12 Subunit p40/immunology
subject: Lipopolysaccharides/immunology
subject: Membrane Glycoproteins/immunology
subject: Phosphorylation
subject: Ribosomal Protein S6 Kinases/genetics
subject: Ribosomal Protein S6 Kinases/metabolism
subject: Signal Transduction
subject: TOR Serine-Threonine Kinases/immunology
subject: Tumor Necrosis Factor-alpha/immunology
subject: Urea/metabolism
subject: 610 Medizin

description: Depletion of arginine is a recognized strategy that pathogens use to evade immune effector mechanisms. Depletion depends on microbial enzymes such as arginases, which are considered virulence factors. The effect is mostly interpreted as being a consequence of successful competition with host enzymes for the substrate. However, both arginases and arginine deiminases (ADI) have been associated with pathogen virulence. Both deplete arginine, but their reaction products differ. An ADI has been implicated in the virulence of Giardia duodenalis, an intestinal parasite that infects humans and animals, causing significant morbidity. Dendritic cells (DC) play a critical role in host defense and also in a murine G. duodenalis infection model. The functional properties of these innate immune cells depend on the milieu in which they are activated. Here, the dependence of the response of these cells on arginine was studied by using Giardia ADI and lipopolysaccharide-stimulated human monocyte-derived DC. Arginine depletion by ADI significantly increased tumor necrosis factor alpha and decreased interleukin-10 (IL-10) and IL-12p40 secretion. It also reduced the upregulation of surface CD83 and CD86 molecules, which are involved in cell-cell interactions. Arginine depletion also reduced the phosphorylation of S6 kinase in DC, suggesting the involvement of the mammalian target of rapamycin signaling pathway. The changes were due to arginine depletion and the formation of reaction products, in particular, ammonium ions. Comparison of NH4+ and urea revealed distinct immunomodulatory activities of these products of deiminases and arginases, respectively. The data suggest that a better understanding of the role of arginine-depleting pathogen enzymes for immune evasion will have to take enzyme class and reaction products into consideration.
sj-pdf-5-tar-10.1177_17534666211028072 – Supplemental material for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Creators: name: Liu, Panpan
name: Zhang, Huali
name: Zeng, Haizhu
name: Meng, Yingxia
name: Gao, Hongchang
name: Zhang, Meilan
name: Zhao, Lei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-5-tar-10.1177_17534666211028072 for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis by Panpan Liu, Huali Zhang, Haizhu Zeng, Yingxia Meng, Hongchang Gao, Meilan Zhang and Lei Zhao in Therapeutic Advances in Respiratory Disease
Additional file 3 of A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery
Creators: name: Kaeslin, Rahel
name: Latal, Beatrice
name: Mitteregger, Elena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Additional file 3. Prisma 2020 abstract checklist.
Facilitating Multi-Electron Chemistry in the F-Block Using Iminoquinone Ligands
Creators: name: Coughlin, Ezra J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Analytical spectrometry
Organometallic chemistry
Inorganic chemistry not elsewhere classified
F-block chemistry

description: The chemistry of the f-block is relatively unknown when compared to the rest of the periodic table. Transition metals and main group elements have enjoyed thorough study and development over the last 200 years, while many of the lanthanides and actinides weren’t even discovered until the 1940’s. This is troublesome, as knowledge of these elements is critical for environmental, industrial and technological advances. Understanding bonding motifs and reactivity pathways is fundamental to advancing the field of f-block chemistry. The use of redox- active ligands has aided in the construction of new bonding modes and discovery of new reaction pathways by providing electrons for these transformations. A particularly successful partnership is formed when redox-active ligands are combined with lanthanides, as these elements are usually considered redox-restricted. A series of lanthanide complexes featuring the iminoquinone ligand in three oxidation states will be discussed. The use of the ligands as a source of electrons for reactivity is also described, with new bonding motifs for lanthanides being realized. The iminoquinone ligand can also serve to break bonds. The uranyl (UO22+) ion is notoriously difficult to handle due to its strong U-O multiple bonds. To overcome this, we developed a series of uranyl complexes and studied the ability of the iminoquinone ligand to serve as an electron source for reduction of uranium, with concomitant U-O bond cleavage.
Additional file 1 of Characteristics associated with SF-36 in alpha-1 antitrypsin deficiency-associated COPD: a cross-sectional analysis
Creators: name: Choate, Radmila
name: Holm, Kristen E.
name: Sandhaus, Robert A.
name: Mannino, David M.
name: Strange, Charlie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
sj-docx-2-tam-10.1177_17588359211022905 – Supplemental material for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03)
Creators: name: Grossi, Francesco
name: Jaśkiewicz, Piotr
name: Ferreira, Marion
name: Czyżewicz, Grzegorz
name: Kowalski, Dariusz
name: Ciuffreda, Libero
name: Garcia-Gomez, Ramon
name: Caruso, Salvatore
name: Bosch-Barrera, Joaquim
name: Gautier, Stéphanie
name: Ta Thanh Minh, Christine
name: Henriet, Sébastien
name: de Castro, Gilberto
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-2-tam-10.1177_17588359211022905 for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03) by Francesco Grossi, Piotr Jaśkiewicz, Marion Ferreira, Grzegorz Czyżewicz, Dariusz Kowalski, Libero Ciuffreda, Ramon Garcia-Gomez, Salvatore Caruso, Joaquim Bosch-Barrera, Stéphanie Gautier, Christine Ta Thanh Minh, Sébastien Henriet and Gilberto de Castro in Therapeutic Advances in Medical Oncology
title: Bue Esther pe triomph Mardoche
title: Bue Esther pe triomph Mardoche
Creators: name: Coat, Joseph (1798-1858)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025

description: Provenance: Bibliothèque Yves Le Gallo, Centre de Recherche Bretonne et Celtique
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sj-docx-7-tam-10.1177_17588359211022905 – Supplemental material for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03)
Creators: name: Grossi, Francesco
name: Jaśkiewicz, Piotr
name: Ferreira, Marion
name: Czyżewicz, Grzegorz
name: Kowalski, Dariusz
name: Ciuffreda, Libero
name: Garcia-Gomez, Ramon
name: Caruso, Salvatore
name: Bosch-Barrera, Joaquim
name: Gautier, Stéphanie
name: Ta Thanh Minh, Christine
name: Henriet, Sébastien
name: de Castro, Gilberto
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-7-tam-10.1177_17588359211022905 for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03) by Francesco Grossi, Piotr Jaśkiewicz, Marion Ferreira, Grzegorz Czyżewicz, Dariusz Kowalski, Libero Ciuffreda, Ramon Garcia-Gomez, Salvatore Caruso, Joaquim Bosch-Barrera, Stéphanie Gautier, Christine Ta Thanh Minh, Sébastien Henriet and Gilberto de Castro in Therapeutic Advances in Medical Oncology
Enabling Precision Medicine With Digital Case Classification at the Point-of-Care
Creators: name: Obermeier, Patrick
name: Muehlhans, Susann
name: Hoppe, Christian
name: Karsch, Katharina
name: Tief, Franziska
name: Chen, Xi
name: Conrad, Tim
name: Böttcher, Sindy
name: Diedrich, Sabine
name: Rath, Barbara
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2016
Subjects: subject: Meningitis
subject: Surveillance
subject: Encephalitis
subject: ADEM
subject: Mobile health
subject: Data standards
subject: 610 Medizin

description: Infectious and inflammatory diseases of the central nervous system are difficult to identify early. Case definitions for aseptic meningitis, encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM) are available, but rarely put to use. The VACC-Tool (Vienna Vaccine Safety Initiative Automated Case Classification-Tool) is a mobile application enabling immediate case ascertainment based on consensus criteria at the point-of-care. The VACC-Tool was validated in a quality management program in collaboration with the Robert-Koch-Institute. Results were compared to ICD-10 coding and retrospective analysis of electronic health records using the same case criteria. Of 68,921 patients attending the emergency room in 10/2010–06/2013, 11,575 were hospitalized, with 521 eligible patients (mean age: 7.6 years) entering the quality management program. Using the VACC-Tool at the point-of-care, 180/521 cases were classified successfully and 194/521 ruled out with certainty. Of the 180 confirmed cases, 116 had been missed by ICD-10 coding, 38 misclassified. By retrospective application of the same case criteria, 33 cases were missed. Encephalitis and ADEM cases were most likely missed or misclassified. The VACC-Tool enables physicians to ask the right questions at the right time, thereby classifying cases consistently and accurately, facilitating translational research. Future applications will alert physicians when additional diagnostic procedures are required.
Rate Estimators for Non-stationary Point Processes
Creators: name: Tatara, Anna N
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other engineering not elsewhere classified
Statistics not elsewhere classified

description: Non-stationary point processes are often used to model systems whose rates vary over time. Estimating underlying rate functions is important for input to a discrete-event simulation along with various statistical analyses. We study nonparametric estimators to the marked point process, the infinite-server queueing model, and the transitory queueing model. We conduct statistical inference for these estimators by establishing a number of asymptotic results.
For the marked point process, we consider estimating the offered load to the system over time. With direct observations of the offered load sampled at fixed intervals, we establish asymptotic consistency, rates of convergence, and asymptotic covariance through a Functional Strong Law of Large Numbers, a Functional Central Limit Theorem, and a Law of Iterated Logarithm. We also show that there exists an asymptotically optimal interval width as the sample size approaches infinity.
The infinite-server queueing model is central in many stochastic models. Specifically, the mean number of busy servers can be used as an estimator for the total load faced to a multi-server system with time-varying arrivals and in many other applications. Through an omniscient estimator based on observing both the arrival times and service requirements for n samples of an infinite-server queue, we show asymptotic consistency and rate of convergence. Then, we establish the asymptotics for a nonparametric estimator based on observations of the busy servers at fixed intervals.
The transitory queueing model is crucial when studying a transitory system, which arises when the time horizon or population is finite. We assume we observe arrival counts at fixed intervals. We first consider a natural estimator which applies an underlying nonhomogeneous Poisson process. Although the estimator is asymptotically unbiased, we see that a correction term is required to retrieve an accurate asymptotic covariance. Next, we consider a nonparametric estimator that exploits the maximum likelihood estimator of a multinomial distribution to see that this estimator converges appropriately to a Brownian Bridge.
sj-pdf-1-pus-10.1177_09636625211022975 – Supplemental material for Science, Maddá, and ‘Ilm: The language divide in scientific information available to Internet users
Creators: name: Zoubi, Kawther
name: Sharon, Aviv J.
name: Nitzany, Eyal
name: Baram-Tsabari, Ayelet
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Science Policy

description: Supplemental material, sj-pdf-1-pus-10.1177_09636625211022975 for Science, Maddá, and ‘Ilm: The language divide in scientific information available to Internet users by Kawther Zoubi, Aviv J. Sharon, Eyal Nitzany and Ayelet Baram-Tsabari in Public Understanding of Science
sj-pdf-1-sci-10.1177_00368504211032084 – Supplemental material for RNA sequencing identified novel target genes for Adansonia digitata in breast and colon cancer cells
Creators: name: El-Masry, Omar S.
name: Goja, Arafat
name: Rateb, Mostafa
name: Owaidah, Amani Y
name: Alsamman, Khaldoon
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-pdf-1-sci-10.1177_00368504211032084 for RNA sequencing identified novel target genes for Adansonia digitata in breast and colon cancer cells by Omar S. El-Masry, Arafat Goja, Mostafa Rateb, Amani Y Owaidah and Khaldoon Alsamman in Science Progress
Inovasi Teknologi AI untuk Penilaian Esai di Era Kurikulum Merdeka
Creators: name: Irfan Ananda, Ismail
name: Qadriati, Qadriati
name: Sufyarma, Marsidin
name: I Ketut, Budaraga
Publisher: name: Harian Singgalang
Year: 2024

description: Inovasi Teknologi AI untuk Penilaian Esai di Era Kurikulum Merdeka" yang terbit di Harian Singgalang pada 7 September 2024, menyoroti terobosan penting dalam dunia pendidikan Indonesia. Dipimpin oleh Irfan Ananda Ismail Staf Ahli Rektor Universitas Ekasati, penelitian ini mengembangkan teknologi Vision Language Model (VLM) untuk membantu guru dalam penilaian esai siswa.Inovasi ini muncul sebagai respons terhadap tantangan yang dihadapi guru dalam era Kurikulum Merdeka, terutama dalam hal objektivitas, konsistensi, dan efisiensi penilaian. VLM dirancang sebagai asisten virtual yang mampu menganalisis jawaban esai berdasarkan rubrik yang telah ditentukan, memberikan penilaian yang konsisten, dan menyediakan umpan balik yang konstruktif bagi siswa.Penelitian menggunakan pendekatan mixed methods dan mendapat dukungan dari berbagai pihak termasuk Pembimbing PPG Universitas Negeri Padang. Tim peneliti juga mempertimbangkan aspek etika dan privasi data dalam pengembangan teknologi ini. Ke depannya, sistem ini akan diuji coba di berbagai sekolah di Indonesia dengan tujuan menjadi standar teknologi penilaian yang dapat mendukung implementasi Kurikulum Merdeka secara efektif.