cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Licensable Power Capacity of the PUR-1 Research Reactor
Creators: name: Townsend, Clive
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Nuclear engineering (incl. fuel enrichment and waste processing and storage)

description: This work aims to develop a theoretical power operations envelope for the PUR-1 reactor. Given the bulk coolant temperature, the reactor’s power level is limited primarily by the Onset of Nucleate Boiling. Additional limitations to the reactor power are explored including the dose rate at the top of the pool due to shine and the airborne effluent of argon and nitrogen. Operations in excess of the facility cooling capacity will be proposed and are already permitted at other US research reactor facilities, provided temperature limitations are met. The MCNP and NATCON code packages have been implemented to assist in power limitation measurement. A brief discussion on the licensing considerations is included to provide some framework for pursuit of these higher power levels. The maximum power consideration ensures continued full use of the facility while maximizing its effectiveness in the teaching laboratories and access to researchers. The final power level is limited by the administrative dose limit at the top of the reactor pool as well as the Onset of Nucleate Boiling power level as a function of bulk pool temperature. The result is an operational envelope which would allow operators to have the maximum neutron flux without changing the facility or creating phase transition within the light water coolant.
The Physiological Relevance of the Adaptive Capacity of Intestinal Phosphorus Absorption
Creators: name: Vorland, Colby J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Nutritional science

description: Intestinal phosphorus absorption is a key contributor to the body phosphorus pool, but much is unknown regarding physiological adaptations in intestinal phosphorus absorption that occur in vivo. We sought to measure changes in intestinal phosphorus absorption efficiency and phosphorus balance in adolescent females and in rats in response to several factors, using physiologically relevant assessment approaches including whole-body phosphorus balance techniques and in situ ligated intestinal loop absorption methods. We first assessed phosphorus balance and net phosphorus absorption in female adolescents from a controlled crossover study with two levels of calcium intake. Despite an increased calcium intake of 600 mg/day, there was no change in phosphorus balance, nor a significant change in net phosphorus absorption. Next, we measured intestinal phosphorus absorption efficiency with the in situ ligated loop method in healthy Sprague Dawley rats as well as the Cy/+ rat model of progressive kidney disease. We found 10-week-old healthy rats had a small but higher absorption efficiency of phosphorus compared to 20- and 30-week-old rats, while 20-week Cy/+ rats had higher absorption efficiency than 30-week-old. Each of these results corresponded to net phosphorus absorption from balance as well as the concentration of 1,25-dihydroxyvitamin D3. In healthy rats, there was no effect of altering the level of phosphorus in the diet on absorption efficiency. In Cy/+ rats, kidney disease produced a small increase in absorption efficiency, contrary to the predicted decrease that would occur with lower 1,25-dihydroxyvitamin D3 observed in CKD. Gene expression of the major intestinal phosphate transporter, NaPi-2b, largely followed absorption patterns. The utility of the Cy/+ model is limited to males as females do not begin to show signs of progressive kidney decline until a much older age. Therefore, we sought to test whether ovariectomy would accelerate kidney disease in Cy/+ females, with the aim of establishing a postmenopausal model of progressive kidney disease. Our results show that kidney disease is not accelerated by ovariectomy in this rat strain, as measured by kidney weight and biochemistries including blood urea nitrogen, creatinine, creatinine clearance, and plasma phosphorus and calcium. Our results utilizing in situ absorption measures as well as net absorption of phosphorus suggest that some of the factors that are understood to influence the intestinal absorption of phosphorus do not have a significant influence in a physiological context.
How Europe is throwing the strategic communication game with China and how it could go all in
Creators: name: Mercator Institute for China Studies
name: Stec, Grzegorz
Publisher: name: Zenodo
Year: 2025
Subjects: MERICS
DWARC
China Horizons
Horizon Europe
Europe
China
Resilience
public perceptions
bilateral diplomatic exchanges
Beijing
readouts
communication
governments
EU-China relations
EU

description: European capitals are giving Beijing too much leeway to shape public perceptions of bilateral diplomatic exchanges, says MERICS Head of Brussels Office and Senior Analyst Grzegorz Stec in his recent analysis of European resilience vis-à-vis China. There are several steps European countries can take to make their messages clearer and more forceful. This analysis is part of the MERICS Europe-China Resilience Audit, including detailed country profiles and further analyses.
166. Hypervelocity stars: part 2
Creators: name: Perryman, Michael
Publisher: name: Zenodo
Year: 2024
Subjects: Gaia

description: In essay 22 (May 2021) I described some of the early insights that Gaia was providing in the field of hypervelocity stars, a rare and exotic type of star, racing through our Galaxy with velocities of 500-1000 km per second or more. Here, I bring the Gaia results up-to-date, describing the latest searches, and more recent insights into their origin.
Palau i Fabre i Itàlia
Creators: name: Ardolino, Francesco
Publisher: name: Institució de les Lletres Catalanes-Departament de Cultura de la Generalitat de Catalunya
Year: 2019
Subjects: subject: Translating and interpreting
subject: Area studies
subject: Catalan literature
subject: Europe--Catalan-speaking regions

description: Aquest estudi se centra, d'una banda, en les relacions de Palau i Fabre amb la literatura, l'art i la cultura italianes; i, de l'altra, en la recepció (molt limitada) de la seva obra.
Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community
Creators: name: Ultsch, Bernhard
name: Damm, Oliver
name: Beutels, Philippe
name: Bilcke, Joke
name: Brüggenjürgen, Bernd
name: Gerber-Grote, Andreas
name: Greiner, Wolfgang
name: Hanquet, Germaine
name: Hutubessy, Raymond
name: Jit, Mark
name: Knol, Mirjam
name: Kries, Rüdiger Von
name: Kuhlmann, Alexander
name: Levy-Bruhl, Daniel
name: Perleth, Matthias
name: Postma, Maarten
name: Salo, Heini
name: Siebert, Uwe
name: Wasem, Jürgen
name: Wichmann, Ole
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: 610 Medizin

description: Background: Incremental cost-effectiveness and cost-utility analyses [health economic evaluations (HEEs)] of vaccines are routinely considered in decision making on immunization in various industrialized countries. While guidelines advocating more standardization of such HEEs (mainly for curative drugs) exist, several immunization-specific aspects (e.g. indirect effects or discounting approach) are still a subject of debate within the scientific community. Objective: The objective of this study was to develop a consensus framework for HEEs of vaccines to support the development of national guidelines in Europe. Methods: A systematic literature review was conducted to identify prevailing issues related to HEEs of vaccines. Furthermore, European experts in the field of health economics and immunization decision making were nominated and asked to select relevant aspects for discussion. Based on this, a workshop was held with these experts. Aspects on ‘mathematical modelling’, ‘health economics’ and ‘decision making’ were debated in group-work sessions (GWS) to formulate recommendations and/or—if applicable—to state ‘pros’ and ‘contras’. Results: A total of 13 different aspects were identified for modelling and HEE: model selection, time horizon of models, natural disease history, measures of vaccine-induced protection, duration of vaccine-induced protection, indirect effects apart from herd protection, target population, model calibration and validation, handling uncertainty, discounting, health-related quality of life, cost components, and perspectives. For decision making, there were four aspects regarding the purpose and the integration of HEEs of vaccines in decision making as well as the variation of parameters within uncertainty analyses and the reporting of results from HEEs. For each aspect, background information and an expert consensus were formulated. Conclusions: There was consensus that when HEEs are used to prioritize healthcare funding, this should be done in a consistent way across all interventions, including vaccines. However, proper evaluation of vaccines implies using tools that are not commonly used for therapeutic drugs. Due to the complexity of and uncertainties around vaccination, transparency in the documentation of HEEs and during subsequent decision making is essential.
ALTERNATIVE METHODOLOGIES FOR BORESIGHT CALIBRATION OF GNSS/INS-ASSISTED PUSH-BROOM HYPERSPECTRAL SCANNERS ON UAV PLATFORMS
Creators: name: Zhou, Tian
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Geomatic engineering not elsewhere classified

description: Low-cost unmanned aerial vehicles (UAVs) utilizing push-broom hyperspectral scanners are poised to become a popular alternative to conventional remote sensing platforms such as manned aircraft and satellites. In order to employ this emerging technology in fields such as high-throughput phenotyping and precision agriculture, direct georeferencing of hyperspectral data using onboard integrated global navigation satellite systems (GNSS) and inertial navigation systems (INS) is required. Directly deriving the scanner position and orientation requires the spatial and rotational relationship between the coordinate systems of the GNSS/INS unit and hyperspectral scanner to be evaluated. The spatial offset (lever arm) between the scanner and GNSS/INS unit can be measured manually. However, the angular relationship (boresight angles) between the scanner and GNSS/INS coordinate systems, which is more critical for accurate generation of georeferenced products, is difficult to establish. This research presents three alternative calibration approaches to estimate the boresight angles relating hyperspectral push-broom scanner and GNSS/INS coordinate systems. For reliable/practical estimation of the boresight angles, the thesis starts with establishing the optimal/minimal flight and control/tie point configuration through a bias impact analysis starting from the point positioning equation. Then, an approximate calibration procedure utilizing tie points in overlapping scenes is presented after making some assumptions about the flight trajectory and topography of covered terrain. Next, two rigorous approaches are introduced – one using Ground Control Points (GCPs) and one using tie points. The approximate/rigorous approaches are based on enforcing the collinearity and coplanarity of the light rays connecting the perspective centers of the imaging scanner, object point, and the respective image points. To evaluate the accuracy of the proposed approaches, estimated boresight angles are used for ortho-rectification of six hyperspectral UAV datasets acquired over an agricultural field. Qualitative and quantitative evaluations of the results have shown significant improvement in the derived orthophotos to a level equivalent to the Ground Sampling Distance (GSD) of the used scanner (namely, 3-5 cm when flying at 60 m).
Figuring the Modern: The Objectified Present in Stéphane Mallarmé and T. S. Eliot
Creators: name: Takeda, Noriko
Publisher: name: Humanities Commons
Year: 2022

description: Contextualizing modern/modernist poetry as an artful objectification, this monograph aims to elucidate the significance of resourceful texts by Stéphane Mallarmé and T. S. Eliot in a symbolist productivity. The engaging texts represent the sublime in verbal extremity: Mallarmé's posthumous manuscript entitled Igitur in an endless circularity for the completion by an incompletion, his article "Ballets" as a printed synthesis of poetry and the performing art, ballet, and Eliot's poetic works in their entirety for a manifold development of the imagery of water that embodies a cosmic inclusion. Particularly, as a swan song for the poet Mallarmé facing a mental crisis, Igitur directs the reader to reconsider the testamentary letters written by the conscripted Japanese students in the Second World War. Representing literature as a holistic combination of the logical and the artistic, the two poets' creation leads the reader to fully recognize the importance of living this moment.
Machine � �mouvoir. Kazu? Shinohara e i dispositivi dell?inatteso
Creators: name: CESARO, GIORGIA
Publisher: name: Universit� IUAV di Venezia
Year: 2020

description: La cultura nipponica antica (e forsanche attuale) � tradizionalista per definizione: nulla pu� esistere al mondo, nel senso pi� ampio del termine, se non ripete modelli antichi. Cos�, la forma, le proporzioni, le misure stesse di una stanza del t�, di un giardino buddhista, di un gesto teatrale o di una terzina poetica sono costruite con soggetti e secondo regole precise, codificate dai trattati e dalla consuetudine. Dopo la codificazione, in teoria, nessun mutamento, cio� nessuna innovazione, pu� essere possibile. Eppure le cose non sono andate e non vanno cos�: la stessa civilt�, le stesse opere offrono l?esempio di una creativit� sfavillante e sottilmente raffinata.
Si impone allora una domanda: se tutto nella cultura nipponica � prefissato dalla tradizione e l?artista ? poeta, attore, architetto ? � divenuto tale imparando a fare l?artista, come un artigiano che ha appreso un mestiere, allora l?intera produzione � condannata a rimanere un mero formalismo, spesso particolarmente sofisticato, ma freddo e ripetitivo? In altre parole: dove risiede l?originalit� formale in cui indubbiamente gli artisti gareggiano? Il processo di animazione dello spazio artistico, tra elaborazione del passato e progettazione del futuro?
Per rispondere la ricerca ha assunto come ambito temporale di riferimento il tema della ricostruzione della citt�, dalla Seconda Guerra Mondiale fino a oggi, e come ambito formale il rapporto fra ?tradizione? e ?innovazione?, tra ?continuit�? e ?sperimentazione? nell?opera dell?architetto giapponese Kazu? Shinohara (1925-2006). Un lavoro, quello del ?maestro? Shinohara, che � stato volto ad affermare l?importanza dello spazio domestico come forma specifica di riscoperta e ricostituzione del senso fondamentale dell?uomo; vale a dire la realizzazione della realt� unitaria della sua vita tra corpo, mente e psiche. Cos� l?architettura diviene una forma capace di racchiudere in s� un?energia vitale, uno spazio ove basta un riflesso per animare un intero scenario, per trasfigurare un insieme monotono e persino desolato in un balenare vivo e inatteso.
Μελέτη συνθετικής μετατροπής α-Ιμινονιτριλίων σε Ν,Ν- και Ν,Ο- ετεροκυκλικά παράγωγα μέσω αντίδρασης ενός σταδίου
Creators: name: Δόλλα, Αργυρώ Φ.
Publisher: name: Aristotle University of Thessaloniki
Year: 2025
Subjects: α-Ιμινονιτρίλια
Ιμιδαζολίνες, Οξαζολίνες, 1,4,5,6- Τετραϋδροπυριμιδίνες
Ετεροκυκλικές ενώσεις, Αντίδραση ενός σταδίου
α-Iminonitriles
Imidazolines, Oxazolines, 1,4,5,6- Tetrahydropyrimidines
Heterocyclic Compounds, One-pot Reaction

description: Στα πλαίσια της μεταπτυχιακής αυτής εργασίας, πραγματοποιήθηκε η σύνθεση μιας βιβλιοθήκης Ν-(πυριδινο-2-υλ)ιμινονιτριλίων, ακολουθώντας ένα απλό συνθετικό πρωτόκολλο με πρώτες ύλες 2-αμινοπυριδίνες και νιτροστυρόλια, παρουσία οξινισμένης αλούμινα Al2O3. Στη συνέχεια, αναπτύχθηκε μία απλή και φιλική προς το περιβάλλον, μεθοδολογία για τη σύνθεση ετεροκυκλικών μορίων όπως οι 2-αρυλο υποκαταστημένες ιμιδαζολίνες, οξαζολίνες και 1,4,5,6-τετραϋδροπυριμιδίνες. Χρησιμοποιήθηκαν ως πρώτες ύλες τα συντιθέμενα αιμινονιτρίλια και διάφορες διαμίνες ή αμινοαλκοόλες για την παρασκευή των επιθυμητών προϊόντων σε υψηλές αποδόσεις. Η συνθετική μεθοδολογία έλαβε χώρα και σε μεγαλύτερη εργαστηριακή κλίμακα της τάξης του 1 mmol. Παράλληλα, διερευνήθηκε η συνθετική αξία των α-ιμινονιτριλίων για την σύνθεση διάφορων Ν,Ν- και Ν,Ο-ετεροκυκλικών ενώσεων όπως τα 2- αρυλο υποκατεστημένα βενζιμιδαζόλια και βενζοξαζόλια.
description: In the context of this MSc Thesis the synthesis of a library of N-(pyridin-2-yl) iminonitriles was carried out, following a simple synthetic protocol in which the starting materials were 2-aminopyridines and nitrostyrenes, in the presence of the acidic catalyst Al2O3. Subsequently, a simple and environmentally friendly methodology was then developed for the synthesis of heterocyclic compounds such as 2-aryl substituted imidazolines, oxazolines and 1,4,5,6-tetrahydropyrimidines. α-Iminonitriles were used with different diamines and amino alcohols for the synthesis of the desired products in great yields. The synthetic methodology also took place on a larger laboratory scale, at 1 mmol scale. In parallel, it is highlighted the synthetic value of α-iminonitriles for the synthesis of various N,N- and N,O-heterocyclic compounds such as 2-aryl-substituted benzimidazoles and benzoxazoles.
Visioni di un Antico Futuro. Orizzonti e frontiere della rappresentazione digitale. Tra Archetipi, Tecnologia e Immersivit�.
Creators: name: GION, ANDREA MARTINO
Publisher: name: Universit� IUAV di Venezia
Year: 2021

description: "Visioni di un Antico Futuro. Orizzonti e frontiere della rappresentazione digitale. Tra Archetipi, Tecnologia e Immersivit�.? nasce con l?obbiettivo di verificare se e in quale misura storytelling digitale e immersive-tecnologies stiano riplasmando i codici espressivi tradizionali propri dell?architettura e, segnatamente, del settore rappresentativo. Il lavoro � stato sviluppato intersecando diversi settori disciplinari e abbracciando molteplici punti di vista, con l?idea di mettere a sistema gli eterogenei ? ma intimamente interconnessi ? ambiti coinvolti nella messa in scena delle immersive experiences. Una riflessione critica che, saltando dagli aspetti definitori a quelli tecnologici, e incrociando le best practice dei massimi esponenti del settore con una sperimentazione verticale realizzata ad hoc, ha provato ad abbozzare una prima linea di riferimento per una disciplina tanto giovane quanto, per molti versi, potenzialmente rivoluzionaria.
Energy Efficient Byzantine Agreement Protocols for Cyber Physical Resilience
Creators: name: Nagaraj, Manish
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Distributed computing and systems software not elsewhere classified
Digital processor architectures
Other information and computing sciences not elsewhere classified
Electrical engineering not elsewhere classified

description: Cyber physical systems are deployed in a wide range of applications from sensor nodes in a factory setting to drones in defense applications. This distributed setting of nodes or processes often needs to reach agreement on a set of values. Byzantine Agreement protocols address this issue of reaching an agreement in an environment where a malicious entity can take control over a set of nodes and deviates the system from its normal operation. However these protocols do not consider the energy consumption of the nodes. We explore Byzantine Agreement protocols from an energy efficient perspective providing both energy resilience where the actions of the Byzantine nodes can not adversely effect the energy consumption of non-malicious nodes as well as fairness in energy consumption of nodes over multiple rounds of agreement.
Instability Measurements on Two Cone-Cylinder-Flares at Mach 6
Creators: name: Benitez, Elizabeth
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Hypersonic propulsion and hypersonic aerothermodynamics
Aerospace engineering not elsewhere classified

description: This research focuses on measurements of a convective shear-layer instability seen naturally in quiet hypersonic flow. Experiments were carried out in the Boeing/AFOSR Mach 6 Quiet Tunnel (BAM6QT) at Purdue University. The BAM6QT provides low-disturbance hypersonic flow with freestream noise levels similar to what would be experienced by a flight vehicle. To obtain high-speed, off-the-surface measurements of the instability, a modified focused laser differential interferometer (FLDI) was first designed to work with the contoured Plexiglas windows available in the tunnel.
A cone-cylinder-flare geometry was then selected to study the instabilities related to an axisymmetric separation bubble at Mach 6. The sharp cone had a 5-degree half-angle, while flare angles of 10 degrees and 3.5 degrees were tested to compare axisymmetric compression with and without separation, respectively. Under quiet flow, laminar separation and reattachment was confirmed by schlieren and surface pressure-fluctuation measurements. Coherent traveling waves were observed. These were attributed to both the second-mode instability, as well as a shear-generated instability from the separation bubble. The symmetry of the bubble was found to be highly sensitive to angle of attack. Additionally, by introducing controlled disturbances on the cone upstream of the separation, larger-amplitude shear-generated waves were measured while the second-mode amplitudes remained unchanged. Therefore, the shear-generated waves were amplified moving through the shear layer, while the second mode remained neutrally stable. These appear to be the first measurements of traveling waves that are generated in the shear layer of a separation bubble in hypersonic flow.
Additional file 1 of Prognostic value of high-sensitivity C-reactive protein in patients undergoing percutaneous coronary intervention with different glycemic metabolism status
Creators: name: Li, Le
name: Liu, Shangyu
name: Zhang, Zhuxin
name: Zhou, Likun
name: Zhang, Zhenhao
name: Xiong, Yulong
name: Hu, Zhao
name: Yao, Yan
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Additional file 1: Table S1. Relationship between hsCRP and indexes of metabolism by linear regression. Table S2. Subgroup analysis for the primary endpoint as the unadjusted model. Table S3. Subgroup analysis for the primary endpoint as the adjusted model. Table S4. Interaction analysis between hsCRP and DM in predicting outcomes. Figure S1. Flow chart. Figure S2. Kaplan–Meier analysis for major adverse cardiovascular outcomes according to A hsCRP and B diabetes mellitus. Figure S3. Kaplan–Meier analysis for major adverse cardiovascular outcomes according to different hsCRP level in the DM A and non-DM B group. Figure S4. Restricted cubic splines of hsCRP levels in relation to adjusted HR for the risk of MACEs.
Spatio-Temporal Video Analysis and the 3D Shearlet Transform
Creators: name: MALAFRONTE, DAMIANO
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: Abstract
The automatic analysis of the content of a video sequence has captured the
attention of the computer vision community for a very long time. Indeed,
video understanding, which needs to incorporate both semantic and dynamic
cues, may be trivial for humans, but it turned out to be a very complex
task for a machine. Over the years the signal processing, computer vision,
and machine learning communities contributed with algorithms that are
today effective building blocks of more and more complex systems. In
the meanwhile, theoretical analysis has gained a better understanding of
this multifaceted type of data. Indeed, video sequences are not only high
dimensional data, but they are also very peculiar, as they include spatial as
well as temporal information which should be treated differently, but are
both important to the overall process. The work of this thesis builds a new
bridge between signal processing theory, and computer vision applications. It
considers a novel approach to multi resolution signal processing, the so-called
Shearlet Transform, as a reference framework for representing meaningful
space-time local information in a video signal. The Shearlet Transform
has been shown effective in analyzing multi-dimensional signals, ranging
from images to x-ray tomographic data. As a tool for signal denoising, has
also been applied to video data. However, to the best of our knowledge,
the Shearlet Transform has never been employed to design video analysis
algorithms. In this thesis, our broad objective is to explore the capabilities of
the Shearlet Transform to extract information from 2D+T-dimensional data.
We exploit the properties of the Shearlet decomposition to redesign a variety
of classical video processing techniques (including space-time interest point
detection and normal flow estimation) and to develop novel methods to better
understand the local behavior of video sequences. We provide experimental
evidence on the potential of our approach on synthetic as well as real data
drawn from publicly available benchmark datasets. The results we obtain
show the potential of our approach and encourages further investigations in
the near future.
Additional file 1 of Treatment setting and buprenorphine discontinuation: an analysis of multi-state insurance claims
Creators: name: Xu, Kevin Y.
name: Gertner, Alex K.
name: Greenfield, Shelly F.
name: Williams, Arthur Robin
name: Grucza, Richard A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Methods S1. Design Diagram. Table S1. Classification of Setting Type. Table S2. Administrative codes for classification of covariates. Table S3. Treatment Setting Type and Time to Buprenorphine Discontinuation, Sensitivity Analyses by Length of Buprenorphine Episode Gap. Table S4. Treatment Setting Type and Time to Buprenorphine Discontinuation, Sensitivity Analyses by Length of Prescription-Prescriber Visit Linkage. Table S5. Treatment Setting Type and Time to Buprenorphine Discontinuation, Controlling for Mean Buprenorphine Dose During Treatment Episode. Table S6. Insurance status, Setting, and 180-day and 365-day buprenorphine retention.
sj-docx-1-pio-10.1177_1748006X211013257 – Supplemental material for Guest Editorial: Value of Information (VoI) in reliability and risk assessment
Creators: name: Maio, F Di
name: Fauriat, W
name: Zio, E
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-pio-10.1177_1748006X211013257 for Guest Editorial: Value of Information (VoI) in reliability and risk assessment by F Di Maio, W Fauriat and E Zio in Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability
"TREATMENT-RESISTANT DEPRESSION" AND USE OF INTRAVENOUS KETAMINE AND INTRANASAL ES-KETAMINE
Creators: name: CUOMO, ALESSANDRO
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Treatment-Resistant Depression (TRD) is defined as major depression characterized by the unsatisfactory response of two or more antidepressant therapies (adequate for dosage and duration), associated with a high incidence of comorbidities, with more marked impairment of functioning socio-occupational and greater risks of relapse, recurrence and suicidality. The high incidence of TRD has advanced scientific research towards the study of molecules with antidepressant action and with different mechanisms of action than those based on the monoaminergic theory. Ketamine is one of these molecules. A non-competitive antagonist of the glutamate N-methyl-D-aspartate (NMDA) receptor, ketamine is mainly used in clinical practice as an anaesthetic and analgesic agent. It has recently been shown that it exerts an antidepressant activity with few and transient side effects at sub anaesthetic doses. Esketamine is the S-enantiomer of ketamine and has recently been FDA approved in the United States for treating depression that has failed to respond to trials of two or more antidepressants. Although the complete molecular mechanism of ketamine is very complex and still partly unknown, it appears that NMDA blockade induces a modulation of several synaptogenic signalling pathways, such as brain-derived neurotrophic factor (BDNF), improving synaptic plasticity of the prefrontal cortex and hippocampus. The design of the observational and retrospective study object of this thesis is evaluating the clinical response following repeated administration of intravenous ketamine (off-label use) and intranasal esketamine in a sample of 16 patients referring to the Psychiatric Clinic of the Siena University Hospital suffering from TRD. The efficacy assessment was performed by administering the Montgomery-Asberg Depression Rating Scale (MADRS) by an expert clinician before and during each entire treatment cycle of ketamine or esketamine intake.
The data appeared to be significant in terms of benefit deriver from intravenous ketamine or intranasal S-ketamine therapy. In particular on the core symptoms of depression, such as sadness, apathy, inability to concentrate and fatigue, as shown by a reduction in the total score MADRS at last dose> 27% of baseline score. The most significant effects were achieved in the first 4 weeks of administration. The study limit is the small number of samples, which are still being implemented.
To date, ketamine and S-ketamine are proven to be one of the few innovative drug therapies effective and safe for the treatment of TRD.
Epidemiologisches Bulletin 04 / 2010
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: Influenza
subject: PIKS
subject: Impfung gegen die Neue Influenza
subject: Kommentar der KRINKO
subject: 610 Medizin

description: In Deutschland wurden bisher knapp 220.000 bestätigte Fälle sowie 189 Todesfälle von Neuer Influenza A/H1N1 gemäß Infektionsschutzgesetz (IfSG) an das Robert Koch-Institut (RKI) übermittelt (Stand 19. Januar 2010).1 Wichtige Indikatoren für die Beurteilung der Schwere einer Influenzawelle sind die Anzahl der mit Influenza assoziierten Erkrankungsfälle sowie Todesfälle, welche in Krankenhäusern auftreten.2,3 Eine Sentinel-Krankenhaus-Surveillance zur bundesweit systematischen Erfassung und Beschreibung der genannten Indikatoren existierte in Deutschland bis zum Jahr 2009 nicht. Deshalb hat das RKI von der 49. Kalenderwoche (KW) 2009 an beginnend die sogenannte „Pandemische Influenza A/H1N1 Krankenhaus Surveillance – PIKS“ implementiert. Durch aktuelle Daten können Änderungen im zeitlichen Verlauf zeitnah erfasst und Empfehlungen sowie Infektionsschutzmaßnahmen entsprechend angepasst werden.
Additional file 1 of An arrhythmogenic metabolite in atrial fibrillation
Creators: name: Krause, Julia
name: Nickel, Alexander
name: Madsen, Alexandra
name: Aitken-Buck, Hamish M.
name: Stoter, A. M. Stella
name: Schrapers, Jessica
name: Ojeda, Francisco
name: Geiger, Kira
name: Kern, Melanie
name: Kohlhaas, Michael
name: Bertero, Edoardo
name: Hofmockel, Patrick
name: Hübner, Florian
name: Assum, Ines
name: Heinig, Matthias
name: Müller, Christian
name: Hansen, Arne
name: Krause, Tobias
name: Park, Deung-Dae
name: Just, Steffen
name: Aïssi, Dylan
name: Börnigen, Daniela
name: Lindner, Diana
name: Friedrich, Nele
name: Alhussini, Khaled
name: Bening, Constanze
name: Schnabel, Renate B.
name: Karakas, Mahir
name: Iacoviello, Licia
name: Salomaa, Veikko
name: Linneberg, Allan
name: Tunstall-Pedoe, Hugh
name: Kuulasmaa, Kari
name: Kirchhof, Paulus
name: Blankenberg, Stefan
name: Christ, Torsten
name: Eschenhagen, Thomas
name: Lamberts, Regis R.
name: Maack, Christoph
name: Stenzig, Justus
name: Zeller, Tanja
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Additional file 1. Table S1. Baseline characteristics of the Würzburg patient cohort. Table S2. Baseline characteristics of the New Zealand patient cohort. Table S3. A Baseline characteristics of the overall BiomarCaRE case-cohort study population. B Baseline characteristics of the subcohorts comprising the BiomarCaRE case-cohort study population. Table S4. Number of individuals included in the BiomarCaRE case-cohort set. Fig. S1. Differentiation of human induced pluripotent stem cells into ventricular and atrial cardiomyocytes. Fig. S2. Force-frequency relationship. Fig. S3. Short-term effect of C18:1AC on contractility of human EHT. Fig. S4. Action potentials of C18:1AC exposed human vEHT and aEHT. Fig. S5. Post-pause force of atrial trabeculae after C18:1AC exposure. Fig. S6. Positive inotropic effect of C18:1AC. Fig. S7. Arrhythmogenic potential of C18:1AC. Fig. S8. Influence of C18:1AC on calcium load and mitochondrial membrane potential in murine ventricular cardiomyocytes. Fig. S9. Influence of C18:1AC on systolic and diastolic calcium load in murine ventricular cardiomyocytes. Fig. S10. Western blots of calcium handling related proteins. Fig. S11. Time and concentration-dependent effect of C18:1AC on human vEHT and aEHT contractility (time course raw data). Fig. S12. Detection of C18:1AC in human EHT. Fig. S13. Biphasic effect of C18:1AC on mitochondrial respiration. Fig. S14. Influence of C18:1AC on mitochondrial respiration.
Incorporating Sustainability Planning in Airport Master Plans: A Case Study of Six U.S Small Hub Airports
Creators: name: Marete, Caroline K
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other engineering not elsewhere classified

description: The Federal Aviation Administration (FAA) Report on the Sustainable Master Plan Pilot Program and Lessons Learned published in December 2012 showed that airports of all sizes can benefit from incorporating sustainability in their master plans. Global aviation organizations such as the International Civil Aviation Organization (ICAO) and Airports Council International (ACI) have been in the forefront in championing aviation sustainability. While incorporating sustainability in airport planning is highly encouraged, there are challenges associated with such a process. Some of the challenges experienced by airport managers in planning and implementation sustainability are lack of financial capability, and lack of skilled sustainability specialists. In 2009, FAA launched the Airport Sustainability - Airport Improvement Program (AIP), to provide grants to airports that were willing to invest the time and resources in preparing airport master plans that incorporate sustainability issues. To date, 44 airports have been funded through the FAA Airport Sustainability AIP grant. Six of the 44 airports are in the category of small hub airports as classified by the National Plan of Integrated Airport Systems (NPIAS). The objective of this study is to gain an in-depth understanding of the approaches to sustainability planning used by the six small hub airports in the FAA program. The researcher chose a case study design to conduct an exploratory case study with multiple cases. The results of the study show that the approaches used by the six airports vary depending on the specific airport needs and resources available. Based on the study results, the researcher concludes there are more similarities than differences in the approaches airports have used to incorporate sustainability in the master planning process.
Developing Population-Specific Brain Atlases and Monitoring Repetitive Head Impacts for Early-to-Middle Adolescent Collision-Sport Athletes
Creators: name: Zou, Yukai
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Medical biochemistry and metabolomics not elsewhere classified
Health informatics and information systems
Neurosciences not elsewhere classified
Psychophysiology
Clinical microbiology
Image processing
Central nervous system
Biostatistics
Health care administration

description: Adolescent collision-sport athletes may be exposed to repetitive head impacts over years of practices and competitions without immediately observable symptoms. Despite the growing concerns, these athletes often continue play while at risk. Concrete objective measurements are desired to inform prompt and effective preventative strategies for this vulnerable population. However, adolescent brains are rapidly developing and the accrual of brain injury is often subtle. Prospective screening with sensitive biomarkers is challenging and requires advanced technologies, rigorous data processing, and the interdisciplinary expertise of engineering, neurobiology, and cognitive sciences.
To address the challenge, we first developed population-specific brain atlases to facilitate reproducible and meaningful statistical analyses. The atlases better characterized the neuroanatomy of early-to-middle adolescent (ages 13-19) collision-sport athletes, reduced deformation introduced during spatial normalization, and exhibited higher sensitivity in image analysis compared to standardized adult or age-appropriate brain templates. The atlases can be further applied to monitor the neuroanatomical trajectory and can serve as a coordinate reference system to retrospectively harmonize data collected from different sites and imaging acquisition parameters, facilitating group analysis at large scale.
Next, to assess whether the changes of white matter microstructure can be attributed to repetitive head impacts and are reflected by cognitive performance, we analysed the diffusion tensor imaging (DTI) data of high school men’s football and women's soccer across a single season, with accompanying data from head impact sensors and neurocognitive assessments. Within multiple brain regions, we observed significantly altered DTI metrics, both transiently over a season and chronically with more years of high school experience. For the football players, hits with peak translational acceleration over 37 g were sufficient to alter the distributions of DTI changes, and deficits in white matter microstructure correlated with poorer performance of anti-saccade task at one month post-season, suggesting increased vulnerability for inhibitory control. Monitoring repetitive head impacts thus provides a temporal profile for identifying at-risk individuals during the competitive season, informing prompt interventional strategies, therefore protecting the brain and cognitive health of early-to-middle adolescent collision-sport athletes in the long run.
The role of UNESCO in the global governance of education
Creators: name: SOLESIN, Luca
Publisher: name: Universit� degli studi di Bergamo
Year: 2018

description: The multiple processes of globalization of the 1990s have drastically changed the context in which governance of education takes place, altering the relationship between sovereignty and territoriality in the education policy development, and transforming education policy spaces, content, and the governance processes, actors and structures. Over the past decades, scholars have tried to explore new frameworks through which to examine the current complex field of power relations in education, and specifically to understand better the role of intergovernmental organizations and the United Nations in it. In the context of the historical turn for international cooperation characterized by the efforts of achieving Sustainable Development Goals, this understanding could be instrumental for finding effective solutions to educational challenges, and for re-orienting educational policies in the light of sustainable development.
Proposing innovative theoretical and methodological frameworks which required an interdisciplinary approach which draw from international relations theories, political economy, philosophy, pedagogy, sociology, and global education studies, applying the global governance theory to education, the research aims to investigate the complex landscape of the global governance of education, focusing on the role of intergovernmental organizations in it and, in particular, it examines the evolution of priorities of the United Nations Educational, Scientific and Cultural Organization (UNESCO) in the agenda-setting process. By means of a mix methodology of content and discourse analyses, the main political and flagship publications of UNESCO are studied throughout a period that begins in 1990 and extends until 2017, since this timeframe encapsulates the timeline of particular international education agendas (Education for All and Sustainable Development Goals) and is marked by the rise of globalization and its effect on the governance of education. The research identifies the evolution of UNESCO?s role in the global governance of education connecting it with the endogenous and exogenous changes of the period selected; it explains how a specific mechanism of agenda-setting has gained relevance in UNESCO?s global governance role; and it illustrates the dialectic relationships between UNESCO?s priorities and those of the global education agendas that the Organization has helped shape. In so doing, this exercise could be useful as it not only provides a fresh outlook on the ways in which education governance can be analysed in contemporary interconnected world, but it also creates new perspectives for studying the role of intergovernmental organizations in global education policy. The findings of this research are a fresh contribution to the field that could be also utilized by governance actors such as UNESCO in order to reflect on, review and problematise their positioning within global governance.
Supplemental Material, sj-docx-1-ptd-10.1177_08968608211023263 - Key elements in selection of pre-dialysis patients for home dialysis
Creators: name: Bonenkamp, Anna A
name: Reijnders, Tom D Y
name: der Sluijs, Anita van Eck van
name: Hagen, E Christiaan
name: Abrahams, Alferso C
name: van Ittersum, Frans J
name: van Jaarsveld, Brigit C
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental Material, sj-docx-1-ptd-10.1177_08968608211023263 for Key elements in selection of pre-dialysis patients for home dialysis by Anna A Bonenkamp, Tom D Y Reijnders, Anita van Eck van der Sluijs, E Christiaan Hagen, Alferso C Abrahams, Frans J van Ittersum and Brigit C van Jaarsveld in Peritoneal Dialysis International
Additional file 1 of Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model
Creators: name: Hørsdal, Oskar Kjærgaard
name: Moeslund, Niels
name: Berg-Hansen, Kristoffer
name: Nielsen, Roni
name: Møller, Niels
name: Eiskjær, Hans
name: Wiggers, Henrik
name: Gopalasingam, Nigopan
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Additional file 1: Figure S1. Cardiac output for each animal. Cardiac output for each animal, n = 8. The four animals in the lactate to control group (A) and the four animals in the control to lactate group (B) plotted from baseline, T0, to study end at T300. Each animal is shown with connected black lines. The pink line marks the mean of the group. The grey masked area from T120 to T180 marks the washout period. Figure S2. Haemodynamic values. Haemodynamic values plotted from baseline, T0, to study end at T300. The grey masked area from T120 to T180 marks the washout period. Data are expressed as mean ± standard deviation (SD). Each group comprised four animals. HR heart rate, MAP mean arterial pressure, mPAP mean pulmonary artery pressure, RAP right atrial pressure, PAWP pulmonary artery wedge pressure, SvO2=mixed venous saturation, P(v-a)CO2 venoarterial CO2 difference, SVR systemic vascular resistance. Figure S3. Schematic pressure-volume loops during lactate infusion compared with control infusion. Schematics of representative pressure-volume loop during lactate (black) compared with placebo (pink). The drawings were made using mean values at the end of each infusion period. Figure S4. Biochemical parameters. Temporal evolution of arterial pH, bicarbonate concentration, sodium concentration and apparent strong ion difference from baseline to study end. The grey area from T120 to T180 marks the washout period. Data are expressed as mean ± standard deviation (SD).
Identification and Characterization of Human Aldose Reductase Differential Inhibitors
Creators: name: PINESCHI, CARLOTTA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: The approach of aldose reductase (AKR1B1) differential inhibition is based on the possibility to inhibit the activity of the enzyme depending on the substrate undergoing transformation. This approach has been proposed to counteract damaging events linked to the activity of AKR1B1 in hyperglycemic conditions (i.e. polyols accumulation and generation of pro-inflammatory signals), leaving unaffected the ability of the enzyme to remove lipid peroxidation deriving toxic aldehydes. In this thesis two different approaches for the identification of AKR1B1 differential inhibitors from both natural and synthetic sources are reported. Zolfino beans water extracts were used as a starting material for the isolation, through hydrophobic interaction chromatography, of AKR1B1 differential inhibitors. The purified active fractions contained a diglycosylated kaempferol; the tentative identification, based on mass spectroscopy results, of this compound as kaempferol 3-O-?-D- glucopyranoside-(2?1)-O-?-D-xylopyranoside (leucoside) was not supported by the kinetic characterization of the inhibitory properties of commercial lecucoside. Thus, the attribution of the chemical structure to the differential inhibitor isolated from Zolfino beans remained at the moment an open question. The second approach deals with a High Throughput Screen (HTS) of a library of 1280 chemical compounds already known to exert different biological actions. An AKR1B1 assay to be performed in 384-well plates was thus optimized in order the HTS could be accomplished. The HTS allowed the selection of 4 promising compounds, that were characterized for their mechanisms of inhibition toward different AKR1B1 substrates, essentially confirming the differential inhibitory features, and tested for their ability to affect cultured human lens epithelial cells viability. Finally, two cellular models suitable to test the ability of molecules to impair AKR1B1 activity in cultured cells and the consequent NF-kB activation were set up.