cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
КРИМИНОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА ОТДЕЛЬНЫХ ВИДОВ ПЕНИТЕНЦИАРНЫХ ПРЕСТУПЛЕНИЙ
Creators: name: МАЙОРОВА СВЕТЛАНА ЕВГЕНЬЕВНА
Publisher: name: Закон и право
Year: 2020
Subjects: КРИМИНОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА
ПРЕСТУПЛЕНИЕ
ХУЛИГАНСТВО
МАССОВЫЕ БЕСПОРЯДКИ
ДЕЗОРГАНИЗАЦИЯ
ОСУЖДЕННЫЙ
ЗАКЛЮЧЕННЫЙ
CRIMINOLOGICAL CHARACTERISTICS
CRIME
HOOLIGANISM
RIOTS
DISORGANIZATION
CONVICTED
PRISONER

description: В статье рассматриваются некоторые виды пенитенциарных преступлений: хулиганство, массовые беспорядки, дезорганизация деятельности учреждений, обеспечивающих изоляцию от общества. Объединение именно данных преступлений в одну группу обусловлено схожестью способов их совершения. Анализ эмпирических источников показал, что детерминанты совершения рассматриваемых преступлений достаточно единообразны. В статье автор постарался подробно рассмотреть причины совершения данных преступлений, обратить внимание на условия их совершения. В статье поднята проблема об упущениях в деятельности по предупреждению рассматриваемых преступлений. В заключение автор указал, на что следует обратить внимание практических работников уголовно-исполнительной системы для более эффективной профилактики данных преступных деяний.This article discusses some types of penal crimes: hooliganism, riots, disorganization of the activities of institutions providing isolation from society. The combination of these crimes in one group is due to the similarity of the methods of their commission. An analysis of empirical sources showed that the determinants of the commission of the crimes in question are quite similar. In the article, the author tried to consider in detail the reasons for the commission of these crimes, to pay attention to the conditions for their commission. The article raises the problem of omissions in the prevention of the crimes in question. In conclusion, the author indicated that attention should be paid to practitioners of the penal system for more effective prevention of these criminal acts.
НЕЗАКОННОЕ ПРОИЗВОДСТВО ЛЕКАРСТВЕННЫХ СРЕДСТВ И МЕДИЦИНСКИХ ИЗДЕЛИЙ
Creators: name: ЧЕРНЫШЕВА ЮЛИЯ АНДРЕЕВНА
Publisher: name: Закон и право
Year: 2020
Subjects: НЕЗАКОННОЕ ОСУЩЕСТВЛЕНИЕ МЕДИЦИНСКОЙ ИЛИ ФАРМАЦЕВТИЧЕСКОЙ ДЕЯТЕЛЬНОСТИ
ПРОИЗВОДСТВО МЕДИЦИНСКОГО ИЗДЕЛИЯ
ПРОИЗВОДСТВО ЛЕКАРСТВЕННЫХ СРЕДСТВ БЕЗ СПЕЦИАЛЬНОГО РАЗРЕШЕНИЯ (ЛИЦЕНЗИИ)
ILLEGAL CARRYING OUT OF MEDICAL OR PHARMACEUTICAL ACTIVITY
PRODUCTION OF MEDICAL PRODUCT
PRODUCTION OF MEDICINES WITHOUT SPECIAL PERMISSION (LICENSE)

description: В статье автор исследует вопросы, связанные с незаконным обращением лекарственных средств. Проводится анализ объекта и предмета преступлений, предусмотренных ст. 235.1 УК РФ. В работе рассматривается уголовно-правовая характеристика незаконных деяний, которые совершаются при производстве лекарственных средств и медицинских изделий.In this article, the author explores issues related to the illegal circulation of medicines. An analysis of the object and subject matter of the offences provided for in article 235.1 of the Criminal code Russian Federation is carried out. The work deals with the criminal legal characteristics of illegal acts committed in the production of medicines and medical products.
(100409) Thomas Nangham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Benefits of Early Adopter Feedback in Innovation Commercialisation
Creators: name: Nakandala, Dilupa
name: Hurriyet, Hilal
name: Perry, Neil
Publisher: name: Western Sydney University
Year: 2020

description: In this report we analyse how successful innovative firms select early adopter users, collect feedback from them and create benefits in the innovation commercialisation stage. Adopting the multiple case study method, we investigated 14 successful innovative firms operating in Australia, conducted in-depth interviews with managers holding high-level responsibilities in the case firms and analysed the data using a thematic analysis method. We find that innovator firms’ access to end users depends on the type of user (corporate or individual), downstream supply chain structure, congruence between the innovation and the core business products as well as built relationships with users. Case firms use an array of strategies to select early adopters and generate specific benefits of user feedback for product innovation. Successful case firms institutionalise the learning from user feedback to create sustained benefits. To institutionalise learning, firms need to interact with users across the innovation process and learn efficiently. Subsequently, governments can promote interactive learning relationships among actors in the national innovation system by diffusing the knowledge created in innovative firms to nudge the behaviour of laggard firms towards best practices.
АНАЛИЗ УГОЛОВНО-ПРАВОВЫХ СРЕДСТВ ОХРАНЫ ПОТЕРПЕВШИХ
Creators: name: МАЙСТРЕНКО ГРИГОРИЙ АЛЕКСАНДРОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: ЗАКОН
ПРАВА
ГРАЖДАНИН
ЛИЧНОСТЬ
ПОТЕРПЕВШИЙ
УГОЛОВНЫЙ КОДЕКС РФ
LAW
RIGHTS
CITIZEN
PERSON
VICTIM
CRIMINAL CODE OF THE RUSSIAN FEDERATION

description: В статье частично проводится уголовно-правовой анализ отечественного законодательства по применению средств защиты потерпевших как в ходе проведения следственных мероприятий, так и в ходе судебного разбирательства. Основное внимание при рассмотрении данной проблемы уделено гражданам, имеющим особенный гражданский статус.The article partially conducts a criminal-legal analysis of domestic legislation on the use of remedies for victims, both during the investigative activities, as well as during the trial. The focus of this issue is on citizens with special civic status.
ПРИЧИНЕНИЕ ВРЕДА ПРИ ЗАДЕРЖАНИИ ЛИЦА, СОВЕРШИВШЕГО ПРЕСТУПЛЕНИЕ, И ВОПРОСЫ ЕГО СОВЕРШЕНСТВОВАНИЯ В УГОЛОВНОМ ПРАВЕ РОССИИ
Creators: name: СМИРНОВ АЛЕКСАНДР МИХАЙЛОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: ПРИЧИНЕНИЕ ВРЕДА ПРИ ЗАДЕРЖАНИИ ЛИЦА
СОВЕРШИВШЕГО ПРЕСТУПЛЕНИЕ
ОБСТОЯТЕЛЬСТВА
ИСКЛЮЧАЮЩИЕ ПРЕСТУПНОСТЬ ДЕЯНИЯ
СОЦИАЛЬНАЯ СПРАВЕДЛИВОСТЬ
HARM DURING THE DETENTION OF THE PERSON WHO COMMITTED THE CRIME
CIRCUMSTANCES PRECLUDING THE CRIME OF ACTS
SOCIAL JUSTICE

description: В статье актуализируется вопрос о внесении изменений и дополнений в ст. 38 Уголовного кодекса Российской Федерации, регламентирующей причинение вреда при задержании лица, совершившего преступление. На основании результатов проведенного исследования предлагается авторский вариант данной уголовно-правовой нормы, обеспечивающий бульшую справедливость при решении вопроса об освобождении граждан, самостоятельно задерживающих таких лиц и причиняющих при этом им вынужденный вред.The article actualizes the issue of making amendments and additions to Art. 38 of the Criminal Code of the Russian Federation governing the infliction of harm during the detention of the person who committed the crime. Based on the results of the study, the author's version of this criminal law is proposed, which provides greater justice in deciding on the release of citizens who independently detain such persons and cause them harm.
УГОЛОВНАЯ ПОЛИТИКА СОВРЕМЕННОЙ РОССИИ КАК СРЕДСТВО БОРЬБЫ С ПРЕСТУПЛЕНИЯМИ КОРРУПЦИОННОЙ НАПРАВЛЕННОСТИ
Creators: name: МЕРЗЛЯКОВ СЕРГЕЙ ЭНГЕЛЬСОВИЧ
name: БОРИСОВ РУСЛАН ВАХАБОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: УГОЛОВНАЯ ПОЛИТИКА
КОРРУПЦИЯ
ВЗЯТКА
КОРРУПЦИОННАЯ ПРЕСТУПНОСТЬ
ПРЕДУПРЕЖДЕНИЕ КОРРУПЦИИ
CRIMINAL POLICY
CORRUPTION
BRIBERY
CORRUPTION CRIME
PREVENTION OF CORRUPTION

description: В статье дается определение современной российской уголовной политике и фиксируется ее место в системе социальной политики государства, в рамках которой и формируются основные направления борьбы с коррупционной преступностью. Определяется необходимость совершенствования институтов уголовного права страны в рамках внесения изменений в ряд статей, обеспечивающих борьбу с преступлениями коррупционной направленности.The article provides a definition of modern Russian criminal policy and fixes its place in the system of social policy of the state, within which the main directions for the fight against corruption crime are formed. The need to improve the institutions of criminal law of the country in the framework of amendments to a number of articles that ensure the fight against corruption-related crimes is fixed
Rhitymna verruca Wang 1991
Creators: name: Jäger, Peter
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Sparassidae
Rhitymna
Rhitymna verruca

description: Rhitymna verruca (Wang 1991) Material examined. 1 male (PJ 2497, SD 129), 1 female (PJ 2498) (SMF 56646), L3. 1 male (SMF 56654), L5, 8.XI.2004, PJ 2488. Further material from Laos (between Vientiane and Luang Prabang) see Jäger (2003). The present specimens represent the first records for the Luang Nam Tha Prov. This species lives in the foliage of shrubs and trees in forests. In the same habitat Thelcticopis severa, Heteropoda dagmarae and Olios spp. were found.
description: Published as part of Jäger, Peter, 2007, Spiders from Laos with descriptions of new species (Arachnida: Araneae), pp. 29-58 in Acta Arachnologica 56 (1) on page 56, DOI: 10.2476/asjaa.56.29, http://zenodo.org/record/818339
description: {"references": ["Jager, P. 2003. Rhitymna Simon 1897: an Asian, not an African spi- der genus. Generic limits and description of new species (Arachnida, Araneae, Sparassidae). Senckenbergiana biologica 82 (1 / 2): 99 - 125."]}
Patients With Recently Diagnosed Nonischemic Cardiomyopathy Benefit From Implantable Cardioverter-Defibrillators
Creators: name: Kadish, Alan
name: Sanders, William
name: Subacius, Haris
name: Schaechter, Andi
name: Goldberger, Jeffrey
name: Levine, Joseph
name: Thattassery, Emil
name: Anderson, Kelley
name: Dyer, Alan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: OBJECTIVES This study sought to determine whether the time from diagnosis to randomization was related to outcome in a clinical trial of implantable cardioverter-defibrillator (ICD) insertion in nonischemic cardiomyopathy. BACKGROUND Whether the duration of nonischemic cardiomyopathy is related to arrhythmic risk and the possible benefit of ICD insertion is unknown. METHODS The Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation (DEFINITE) trial randomized 458 patients with nonischemic dilated cardiomyopathy and a left ventricular ejection fraction <36% to receive standard medical therapy with or without an ICD. Patients were randomized regardless of the duration of known cardiomyopathy as long as a reversible cause of left ventricular dysfunction was not present. Patients were divided into recently and remotely diagnosed nonischemic cardiomyopathy groups based on the time from diagnosis of cardiomyopathy to randomization. To categorize patients, cut points of three and nine months were used. RESULTS Patients with recently diagnosed cardiomyopathy who received an ICD had better survival than those treated with standard therapy at both cut points. This difference in survival was significant at three months (p < 0.05) and was borderline significant at nine months (p = 0.058). Patients with remotely diagnosed cardiomyopathy did not have a significant survival benefit with ICD insertion, but there were no significant differences between ICD benefit in the recent and remote diagnosis groups (p = 0.17 and 0.25). CONCLUSIONS Patients who have a recent cardiomyopathy diagnosis do not have any less ICD benefit than those with a remote diagnosis. Thus, ICD therapy should be considered in such patients as soon as they are identified as long as a reversible cause of left ventricular dysfunction is excluded.
УГОЛОВНО-ПРАВОВОЕ ЗНАЧЕНИЕ ПРЕСТУПЛЕНИЯ, СОВЕРШЕННОГО В ПЕРВЫЙ РАЗ В ЖИЗНИ С НЕОСТОРОЖНОЙ ФОРМОЙ ВИНЫ
Creators: name: ПАРХОМЕНКО ДМИТРИЙ АЛЕКСАНДРОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: СОВЕРШЕНИЕ ПРЕСТУПЛЕНИЯ ВПЕРВЫЕ
НЕОСТОРОЖНОЕ ПРЕСТУПЛЕНИЕ
УГОЛОВНО-ПРАВОВОЕ ЗНАЧЕНИЕ
КАТЕГОРИИ ПРЕСТУПЛЕНИЙ
ОСВОБОЖДЕНИЕ ОТ НАКАЗАНИЯ
COMMITTING A CRIME FOR THE FIRST TIME
CARELESS CRIME
CRIMINAL LEGAL SIGNIFICANCE
CATEGORIES OF CRIMES
EXEMPTION FROM PUNISHMENT

description: На основе системного анализа норм УК РФ о неосторожных преступлениях обращается внимание на отсутствие четкой градации уголовно-правового значения преступлений в зависимости от формы их вины. В связи с этим автор, используя результаты проведенного им исследования, высказал предложения по совершенствованию уголовного законодательства в данном направлении.Based on a systematic analysis of the criminal code rules on careless crimes, attention is drawn to the lack of a clear gradation of the criminal legal meaning of crimes depending on the form of their guilt, and therefore, using the results of the study conducted by the author, suggestions are made to improve the criminal legislation in this direction.
ПОНЯТИЕ И ПРОБЛЕМЫ КОРРУПЦИИ В ОБРАЗОВАТЕЛЬНОЙ СФЕРЕ
Creators: name: РАМАЗАНОВА ШИРИН ДЖАМАЛУТДИНОВНА
name: ИБРАГИМОВА АНЖЕЛА МАГОМЕДОВНА
Publisher: name: Закон и право
Year: 2020
Subjects: КОРРУПЦИЯ
ОБРАЗОВАНИЕ
КОРРУПЦИЯ В ОБРАЗОВАНИИ
ПОЛУЧЕНИЕ ВЗЯТКИ
ПРЕПОДАВАТЕЛЬ
АНТИКОРРУПЦИОННЫЕ МЕРЫ
CORRUPTION
EDUCATION
CORRUPTION IN EDUCATION
BRIBERY
THE TEACHER
PREVENTING MEASURES IN CORRUPTION

description: В статье анализируется коррупция как социально-правовое явление, выявляются ее причины и последствия. Рассмотрены проблемы коррупции в России и эффективность противодействия данному явлению. Анализируется многообразие проявлений коррупции в вузах. Изучены отдельные проблемы коррупции в образовательной сфере, вскрыты причины и формы ее проявления. Показана общественная опасность этого явления для высшей школы и в целом для развития российского общества. Рассмотрены предположительные меры противодействия коррупции.The article analyzes corruption as a social and legal phenomenon, identifies its causes and consequences. The article considers the problems of corruption in Russia and the effectiveness of its counteraction. The article analyzes the variety of manifestations of corruption in higher education institutions. The author studies some problems of corruption in the educational sphere, reveals the causes and forms of its manifestation. The article shows the social danger of this phenomenon for higher education and for the development of Russian society in General. The article considers the possible measures to counter corruption.
(100411) John Thomas
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(100408) Robert Mullet
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Subclasses of Type Ia Supernovae as the origin of [α/Fe] ratios in dwarf spheroidal galaxies
Creators: name: Kobayashi, Chiaki
name: Nomoto, Ken'ichi
name: Hachisu, Izumi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recent extensive observations of Type Ia Supernovae (SNe Ia) have revealed the existence of a diversity of SNe Ia, including SNe Iax. We introduce two possible channels in the single degenerate scenario: 1) double detonations in sub-Chandrasekhar (Ch) mass CO white dwarfs (WDs), where a thin He envelope is developed with relatively low accretion rates after He novae even at low metallicities, and 2) carbon deflagrations in Ch-mass possibly hybrid C+O+Ne WDs, where WD winds occur at [Fe/H] ~ -2.5 at high accretion rates. These subclasses of SNe Ia are rarer than `normal' SNe Ia and do not affect the chemical evolution in the solar neighborhood, but can be very important in metal-poor systems with stochastic star formation. In dwarf spheroidal galaxies in the Local Group, the decrease of [α/Fe] ratios at [Fe/H] ~ -2 to -1.5 can be produced depending on the star formation history. SNe Iax give high [Mn/Fe], while sub-Ch-mass SNe Ia give low [Mn/Fe], and thus a model including a mix of the two is favoured by the available observations.
description: 6 pages, 4 figures, accepted for publication in ApJ Letters
НЕКОТОРЫЕ ДОКТРИНАЛЬНЫЕ ПОДХОДЫ К ПРОБЛЕМНЫМ ВОПРОСАМ ЭФФЕКТИВНОСТИ НАКАЗАНИЯ
Creators: name: ЖИРОВ РУСЛАН МИХАЙЛОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: ТЕОРИЯ УГОЛОВНОГО ПРАВА
НАУКА УГОЛОВНО-ИСПОЛНИТЕЛЬНОГО ПРАВА
НАКАЗАНИЕ
ЦЕЛИ
ЭФФЕКТИВНОСТЬ
ПРОБЛЕМЫ
THEORY OF CRIMINAL LAW
SCIENCE OF CRIMINAL ENFORCEMENT LAW
PUNISHMENT
GOALS
EFFICIENCY
PROBLEMS

description: В данной статье предпринята попытка рассмотреть некоторые доктринальные подходы к проблемным вопросам эффективности наказания в виде лишения свободы. В качестве сравнения приводится раскрытие термина «эффективность» в философии и экономике; проводится анализ позитивных, спорных и не очень удачных, на взгляд автора, определений термина «эффективность наказания», существовавших ранее и ныне существующих в теории уголовного и уголовно-исполнительного права.This article attempts to address some doctrinal approaches to problematic issues of the effectiveness of custodial punishment. The disclosure of the term «efficiency» in philosophy and economics is cited as a comparison; An analysis is being made of the positive, controversial and not very successful definitions, in the author ‘s view, of the term «effectiveness of punishment», which existed previously and now in the theory of criminal and penal enforcement law.
title: Evaluation of mechanical properties and corrosion behavior of wire arc additively manufactured 13CR (AISI 420)
Creators: name: Lunde, Jonas Halvorsen
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: In this study, a 13Cr stainless steel multi-layer thin-wall part was fabricated using wire arc additive manufacturing (WAAM). In Chapter 1 the microstructure and mechanical properties of the bottom, middle and top regions in as-printed condition were investigated. A multi-phase microstructure consisting of a hard martensitic matrix along with retained austenite and delta ferrite was detected for all regions. The top region exhibited both lower strength and elongation compared with the other regions, due to the presence of harder martensite with vermicular delta ferrite. In Chapter 2 a post-fabrication heat treatment was applied to the as-printed part. Here, austenitizing and quenching eliminated the detrimental secondary phases and the microstructure and corrosion behavior after tempering at 300°C, 400°C, 500°C, and 600°C for 2 hours were investigated. Electrochemical tests revealed that tempering at 400°C provided the best corrosion resistance and tempering at 500°C provided the worst resistance. In chapter 3 tempering at 400°C was looked into further by varying the tempering time; 1 h, 2h, 4h, and 8h were investigated by microstructural observations and electrochemical testing. A decreasing corrosion resistance with increasing tempering time was found due to the growth of intergranular carbide precipitates.
On the transition period of implementing new mathematics curriculum for Foundation Engineering students
Creators: name: Karjanto, N.
name: Osman, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: History and Overview (math.HO)
subject: FOS: Mathematics
subject: 97A99, 97B70, 97C70, 97D80

description: An overview on several mathematics modules in the transition period of introducing a new curriculum for the Foundation programme in Engineering at the University of Nottingham Malaysia Campus is discussed in this paper. In order to progress to Undergraduate programmes in Engineering, previously the students must complete three mathematics modules of 40 credit points in total, for which one of them was a year-long module with 20 credit points. Currently under the new curriculum, the students are required to complete five mathematics modules with 10 credit points each. The new curriculum gives positive impacts for both the lecturers and the students in terms of material organization, fully utilizing textbooks and a new arrangement for tutorial sessions. The new curriculum also provides the students with stronger mathematical background in critical thinking and problem solving skills to equip them to embark the Undergraduate programmes in Engineering.
description: 17 pages
(100404) Unknown Morgan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Influence of Blood Pressure on the Effectiveness of a Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine in the African-American Heart Failure Trial
Creators: name: Adams, Kirkwood
name: Worcel, Manuel
name: Rector, Thomas
name: Cohn, Jay
name: Taylor, Anne
name: Archambault, W. Tad
name: Sabolinski, Michael
name: Anand, Inder
name: Tam, S. William
name: Olukotun, Adeoye
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: OBJECTIVES: This study sought to assess the effect of baseline systolic blood pressure (SBP) and changes in SBP on the effectiveness of treatment with fixed-dose combination of isosorbide dinitrate and hydralazine (FDC I/H) in patients with heart failure (HF). BACKGROUND: Low SBP is a risk factor for adverse outcomes in patients with HF. However, FDC I/H lowered SBP in the A-HeFT (African-American Heart Failure Trial) and yet prolonged survival. Whether blood pressure (BP) lowering is critical to the efficacy of FDC I/H and whether a low BP limits its effectiveness is unclear. METHODS: The effects of FDC I/H on SBP and on mortality and hospitalization were compared in patients with a low or high baseline SBP using multivariable Cox regression models. The interaction between the effect of treatment and baseline SBP was examined. RESULTS: Mean +/- SD baseline SBP in all of the patients was 126 +/- 18 mm Hg. Patients with baseline SBP equal to or below the median (126 mm Hg) had features of more severe HF. Baseline SBP equal to or below the median was an independent risk factor for death (hazard ratio [HR] 2.09; 95% confidence interval [CI] 1.02 to 4.29) or first hospitalization for HF (HR 1.66; 95% CI 1.18 to 2.34). The FDC I/H treatment reduced BP in patients with SBP above the median but not in patients with SBP below 126 mm Hg. The FDC I/H treatment was associated with a similar decrease in mortality or hospitalization for HF in patients with SBP below the median and above the median. The effects of FDC I/H on mortality alone were also similar. CONCLUSIONS: In A-HeFT, patients with lower SBP had a greater risk but a similar relative benefit from the use of FDC I/H as those with higher SBP. The FDC I/H treatment did not reduce SBP in patients with low SBP. An asymptomatic low SBP should not be considered a contraindication to use of FDC I/H in patients with HF.
Inner functions and inner factors of their derivatives
Creators: name: Dyakonov, Konstantin M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Classical Analysis and ODEs (math.CA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 30H05, 30H10, 30J05, 47B35

description: For an inner function $θ$ with $θ'\in\mathcal N$, where $\mathcal N$ is the Nevanlinna class, several problems are posed in connection with the canonical (inner-outer) factorization of $θ'$.
description: 5 pages; to appear in Integral Equations and Operator Theory
ПОНЯТИЕ И ПРАВОВАЯ ПРИРОДА ПРИНУДИТЕЛЬНЫХ МЕР МЕДИЦИНСКОГО ХАРАКТЕРА
Creators: name: ПЕТРОВ КОНСТАНТИН НИКОЛАЕВИЧ
name: МОИСЕЕНКО ЕВГЕНИЙ ЕВГЕНЬЕВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: ПРИНУДИТЕЛЬНЫЕ МЕРЫ МЕДИЦИНСКОГО ХАРАКТЕРА
ПРИНУДИТЕЛЬНОЕ ЛЕЧЕНИЕ
УГОЛОВНО-ПРАВОВОЕ ПРИНУЖДЕНИЕ
МЕРЫ УГОЛОВНО-ПРАВОВОЙ ЗАЩИТЫ
МЕРЫ СОЦИАЛЬНОЙ ЗАЩИТЫ
COMPULSORY MEDICAL MEASURES
COMPULSORY TREATMENT
CRIMINAL LAW ENFORCEMENT
CRIMINAL LAW PROTECTION MEASURES
SOCIAL PROTECTION MEASURES

description: Авторы обращаются к анализу правовой природы института принудительных мер медицинского характера в российском уголовном праве. В статье последовательно рассматриваются юридические, социальные и медицинские аспекты принудительных мер медицинского характера. Авторы анализируют основные теоретические подходы к определению данных мер. Делается вывод о необходимости разработки четкой дефиниции принудительных мер медицинского характера и ее законодательного закрепления.The authors analyzes the legal nature of the institution of compulsory medical measures in Russian criminal law. The article consistently examines the legal, social and medical aspects of compulsory medical measures. The authors analyzes the main theoretical approaches to the definition of these measures. It is concluded that it is necessary to develop a clear definition of compulsory medical measures and its legislative consolidation.
(100406) William Morgan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Anti-Ischemic Mechanism of Action of Ranolazine in Stable Ischemic Heart Disease
Creators: name: Sano, Junko
name: Stone, Peter
name: Chaitman, Bernard
name: DeVault, Arthur
name: Koch, Gary
name: Stocke, Karen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: OBJECTIVES: The purpose of this explanatory analysis was to investigate the relationship between ST-segment depression and the rate-pressure product (RPP) during exercise to determine whether ranolazine's mechanism of action was related to a reduction in myocardial oxygen demand or preservation of myocardial oxygen supply. BACKGROUND: In patients with stable ischemic heart disease, ranolazine increases exercise duration and reduces maximal ST-segment depression while exerting minimal effects on heart rate and blood pressure, although its mechanism of action during exercise has not been investigated. METHODS: Patients with stable ischemic heart disease (n = 191) were randomly allocated to a 4-period, double-blind, balanced Latin square crossover study to receive placebo, and ranolazine 500, 1,000, and 1,500 mg twice daily (bid) for 1 week each. Exercise treadmill tests were performed at baseline and at the end of each treatment period. The RPP and ST-segment depression were assessed before starting exercise, at each stage of exercise, and at maximal exercise. RESULTS: Compared with placebo, ranolazine produced a dose-dependent reduction in ST-segment depression that became more marked as exercise-induced ischemia became more pronounced, associated with clinically minor decreases in heart rate and blood pressure. At 12-min exercise, the amount of ST-segment depression compared with placebo and controlled for RPP was reduced by 22.3% on ranolazine 500 mg bid (p = 0.137), by 35.4% on 1,000 mg bid (p = 0.005), and by 45.8% on 1,500 mg bid (p < 0.001). CONCLUSIONS: The progressive magnitude of ischemia reduction on ranolazine was proportionally more substantial than the minor reductions in heart rate or RPP, suggesting that ranolazine's beneficial mechanism of action is most likely primarily due to an improvement in regional coronary blood flow in areas of myocardial ischemia.
Radio-AGN Feedback: When the Little Ones were Monsters
Creators: name: Williams, W. L.
name: Röttgering, H. J. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a study of the evolution of the fraction of radio-loud active galactic nuclei (AGN) as a function of their host stellar mass. We make use of two samples of radio galaxies: one in the local universe, $0.01 < z < 0.3$, using a combined SDSS-NVSS sample and one at higher redshifts, $0.5 < z < 2$, constructed from the VLA-COSMOS_DEEP Radio Survey at 1.4 GHz and a K$_s$-selected catalogue of the COSMOS/UltraVISTA field. We observe an increase of more than an order of magnitude in the fraction of lower mass galaxies ($M_* < 10^{10.75}$ M$_{\odot}$) which host Radio-Loud AGN with radio powers $P_{1.4GHz} > 10^{24}$ W/Hz at z ~ 1-2 while the radio-loud fraction for higher mass galaxies ($M_* > 10^{11.25}$ M$_{\odot}$) remains the same. We argue that this increase is driven largely by the increase in cold or radiative mode accretion with increasing cold gas supply at earlier epochs. The increasing population of low mass Radio-Loud AGN can thus explain the upturn in the Radio Luminosity Function (RLF) at high redshift which is important for understanding the impact of AGN feedback in galaxy evolution.
description: Accepted for publication in MNRAS; 9 pages, 7 figures
The role of 3-body H$_2$ formation in the fragmentation of primordial gas
Creators: name: Dutta, Jayanta
name: Nath, Biman B.
name: Clark, Paul C.
name: Klessen, Ralf S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: It has been shown that the behaviour of primordial gas collapsing in a dark matter minihalo can depend on the adopted choice of 3-body H$_2$ formation rate. The uncertainties in this rate span two orders of magnitude in the current literature, and so it remains a source of uncertainty in our knowledge of population III star formation. Here we investigate how the amount of fragmentation in primordial gas depends on the adopted 3-body rate. We present the results of calculations that follow the chemical and thermal evolution of primordial gas as it collapses in two dark matter minihalos. Our results on the effect of 3-body rate on the evolution until the first protostar forms agree well with previous studies. However, our modified version of GADGET-2 SPH also includes sink particles, which allows us to follow the initial evolution of the accretion disc that builds up on the centre of each halo, and capture the fragmentation in gas as well as its dependence on the adopted 3-body H$_2$ formation rate. We find that the fragmentation behaviour of the gas is only marginally effected by the choice of 3-body rate co-efficient, and that halo-to-halo differences are of equal importance in affecting the final mass distribution of stars.
description: 8 pages, 5 figures, accepted to MNRAS
title: (Авто)биографии современных горожан 1945 года рождения как источник сведений по антропологии Ленинграда — Петербурга
Creators: name: Сымонович, Ч. Э.
Publisher: name: Реноме
Year: 2023

description: В статье представлен аналитический обзор, обобщающий сто (автобиографических очерков современных жителей Санкт-Петербурга 1945 года рождения, опубликованных в сборнике «Ровесники Победы: истории наших читателей», который был издан ЦГПБ им. В. В. Маяковского в 2020 году. Научная актуальность публикации сборника состоит в значимости первичных личностных автобиографических и биографических материалов как источников сведений не только об обстоятельствах жизни нынешних жителей Санкт-Петербурга, рожденных в 1945 году, но и об их восприятии, переживании этапов своей жизни, о представлении в их сознании ее «смысла». Главная ценность материалов сборника состоит в социальном и культурном, психологическом многообразии, разнохарактерности и представленных в нем воспоминаний, и их авторов. Благодаря этому биографические воспоминания могут быть использованы как исторический источник представителями социальных и гуманитарных наук. При этом в статье подчеркивается характерная тональная заданность, которая проявляется в содержании и форме воспоминаний. Это объясняется тем, что отбор и первичная редактура текстов осуществлялись в районных библиотеках, которые собирали воспоминания горожан.
Safety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19
Creators: name: Eron, Joseph J.
name: Yan, Li
name: Li, Jonathan Z.
name: Bender Ignacio, Rachel
name: Chew, Kara W.
name: Mocherla, Bharat
name: Zhu, Qing
name: Wohl, David Alain
name: ACTIV-2/A5401 Study Team
name: D’Andrea Nores, Ulises
name: Ritz, Justin
name: Currier, Judith S.
name: Moser, Carlee
name: Choudhary, Manish C.
name: Margolis, David
name: Hughes, Michael D.
name: Pinilla, Mauricio
name: Zhong, Lijie
name: Fletcher, Courtney V.
name: Hoover, Keila
name: Javan, Arzhang Cyrus
name: Daar, Eric S.
name: Deo, Rinki
name: Ma, Ji
name: Smith, Davey
name: Fischer, William A.
name: Evering, Teresa H.
name: Giganti, Mark J.
Publisher: name: American College of Physicians
Year: 2023

description:
BACKGROUND: Development of safe and effective SARS-CoV-2 therapeutics is a high priority. Amubarvimab and romlusevimab are noncompeting anti-SARS-CoV-2 monoclonal antibodies with an extended half-life. OBJECTIVE: To assess the safety and efficacy of amubarvimab plus romlusevimab. DESIGN: Randomized, placebo-controlled, phase 2 and 3 platform trial. (ClinicalTrials.gov: NCT04518410). SETTING: Nonhospitalized patients with COVID-19 in the United States, Brazil, South Africa, Mexico, Argentina, and the Philippines. PATIENTS: Adults within 10 days onset of symptomatic SARS-CoV-2 infection who are at high risk for clinical progression. INTERVENTION: Combination of monoclonal antibodies amubarvimab plus romlusevimab or placebo. MEASUREMENTS: Nasopharyngeal and anterior nasal swabs for SARS-CoV-2, COVID-19 symptoms, safety, and progression to hospitalization or death. RESULTS: Eight-hundred and seven participants who initiated the study intervention were included in the phase 3 analysis. Median age was 49 years (quartiles, 39 to 58); 51% were female, 18% were Black, and 50% were Hispanic or Latino. Median time from symptom onset at study entry was 6 days (quartiles, 4 to 7). Hospitalizations and/or death occurred in 9 (2.3%) participants in the amubarvimab plus romlusevimab group compared with 44 (10.7%) in the placebo group, with an estimated 79% reduction in events (P < 0.001). This reduction was similar between participants with 5 or less and more than 5 days of symptoms at study entry. Grade 3 or higher treatment-emergent adverse events through day 28 were seen less frequently among participants randomly assigned to amubarvimab plus romlusevimab (7.3%) than placebo (16.1%) (P < 0.001), with no severe infusion reactions or drug-related serious adverse events. LIMITATION: The study population was mostly unvaccinated against COVID-19 and enrolled before the spread of Omicron variants and subvariants. CONCLUSION: Amubarvimab plus romlusevimab was safe and significantly reduced the risk for hospitalization and/or death among nonhospitalized adults with mild to moderate SARS-CoV-2 infection at high risk for progression to severe disease. PRIMARY FUNDING SOURCE: National Institute of Allergy and Infectious Diseases of the National Institutes of Health.
X-ray radiation damage cycle of solvated inorganic ions
Creators: name: Bloß, Dana
name: Trinter, Florian
name: Unger, Isaak
name: Zindel, Christina
name: Honisch, Carolin
name: Viehmann, Johannes
name: Kiefer, Nils
name: Marder, Lutz
name: Küstner-Wetekam, Catmarna
name: Heikura, Emilia Jasmiina
name: Cederbaum, Lorenz Srulek
name: Björneholm, Olle
name: Hergenhahn, Uwe
name: Ehresmann, Arno
name: Hans, Andreas
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: atomic and molecular interactions with photons
subject: chemical physics
subject: electron transfer
subject: energy transfer
subject: 530
subject: 540
subject: Röntgenstrahlung
subject: Strahlenschaden
subject: Ion
subject: Strahlenchemie
subject: Energietransfer
subject: Elektronentransfer

description: Gefördert im Rahmen des Projekts DEAL
СХЕМЫ ПРЕСТУПЛЕНИЙ С ИСПОЛЬЗОВАНИЕМ КРИПТОВАЛЮТЫ
Creators: name: СИМАКОВ АЛЕКСАНДР АЛЕКСАНДРОВИЧ
name: НЕЕЛОВ ВАДИМ ВЛАДИСЛАВОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: КРИПТОВАЛЮТЫ
ПРАВОВОЕ РЕГУЛИРОВАНИЕ
ЭЛЕКТРОННЫЕ ПЛАТЕЖНЫЕ СИСТЕМЫ
ПРЕСТУПНАЯ СХЕМА
МОШЕННИЧЕСТВО
БИТКОИН
МАЙНИНГ
CRYPTOCURRENCIES
LEGAL REGULATION
ELECTRONIC PAYMENT SYSTEMS
CRIMINAL SCHEME
FRAUD
BITCOIN
MINING

description: Развитие электронных платежных систем на основе криптовалют и отсутствие правового регулирования отношений среди субъектов этой системы, неопределенность позиции государства к криптовалютам как средству платежа позволяет криминальным элементам использовать криптовалюты в преступных целях для легализации денег, полученных незаконным путем.The development of electronic payment systems based on cryptocurrencies and the lack of legal regulation of relations among the subjects of this system, the uncertainty of the state's position on cryptocurrencies as a means of payment allows criminal elements to use cryptocurrencies for criminal purposes to legalize money obtained illegally
Guide to COVID-19 Rapid Response Data Sharing and Deposit for Canadian Researchers
Creators: name: Portage COVID-19 Working Group
name: Fry, Jane
name: Ripp, Chantal
name: Tayler, Felicity
name: Minglu Wang
name: Thompson, Kristi
name: Costanzo, Lucia
name: Szigeti, Kathy
name: Zhang, Qian
name: Dickson, Rebecca
name: Reka, Roger
name: Rochlin, Nick
name: Leggott, Mark
name: Clary, Erin
name: Knazook, Beth
name: Parlette-Stewart, Melanie
Publisher: name: Zenodo
Year: 2020

description: This guide for Canadian researchers is based on the Research Data Alliance (RDA) COVID-19 Working Group Recommendations and Guidelines for Data Sharing, which were designed to help researchers follow best practices for data sharing in their discipline and maximize the impact of their work. This guide is modelled on previous work of Tayler and Ripp (2020) FAQ: COVID-19 Rapid Response Data Sharing and Deposit Support.
(100401) John Morgan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
О ДОПУСТИМОСТИ ИСПОЛЬЗОВАНИЯ РЕШЕНИЙ КОНСТИТУЦИОННОГО СУДА РОССИЙСКОЙ ФЕДЕРАЦИИ В КАЧЕСТВЕ ИСТОЧНИКОВ УГОЛОВНОПРОЦЕССУАЛЬНОГО ПРАВА
Creators: name: ТАТАРОВ ЛЕОН АНАТОЛЬЕВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: УГОЛОВНО-ПРОЦЕССУАЛЬНЫЙ КОДЕКС РФ
УГОЛОВНЫЙ ПРОЦЕСС
ИСТОЧНИКИ УГОЛОВНО-ПРОЦЕССУАЛЬНОГО ПРАВА
КОНСТИТУЦИОННЫЙ СУД РФ
ФЕДЕРАЛЬНЫЙ КОНСТИТУЦИОННЫЙ ЗАКОН РФ "О КОНСТИТУЦИОННОМ СУДЕ РОССИЙСКОЙ ФЕДЕРАЦИИ" ОТ 12 ИЮЛЯ 1994 Г
РЕГЛАМЕНТ КОНСТИТУЦИОННОГО СУДА РФ
РЕШЕНИЯ
ПОСТАНОВЛЕНИЯ
ОПРЕДЕЛЕНИЯ
ЗАКЛЮЧЕНИЕ
CRIMINAL PROCEDURE CODE OF THE RUSSIAN FEDERATION
CRIMINAL PROCEDURE THE SOURCES OF CRIMINAL PROCEDURAL LAW
CONSTITUTIONAL COURT OF THE RUSSIAN FEDERATION
THE FEDERAL CONSTITUTIONAL LAW "ON THE CONSTITUTIONAL COURT OF THE RUSSIAN FEDERATION" OF 12 JULY 1994
THE RULES OF THE CONSTITUTIONAL COURT OF THE RUSSIAN FEDERATION
JUDGMENT
DECREE
DETERMINATION
SENTENCE

description: В статье на основе анализа юридической литературы и законодательства об источниках уголовно-процессуального права обосновано несколько суждений: источниками уголовно-процессуального права являются нормативные правовые акты с разной юридической силой, в которых закреплены положения об уголовно-процессуальной деятельности; Конституция РФ является источником уголовно-процессуального-права, но опосредованно; нормативным правовым актом, специально предназначенным для регулирования уголовно-процессуальных отношений, является Уголовнопроцессуальный кодекс РФ; из решений Конституционного Суда РФ могут быть признаны источниками уголовно-процессуального права лишь постановления, причем опосредованно.The article based on the analysis of the legal literature and legislation on the sources of criminal procedure law justifies several judgments: sources of criminal procedural law are normative legal acts of different legal force, which enshrined provisions on criminal procedure; the Constitution is the source of criminal procedural law, but indirectly; laws and regulations specifically designed to regulate criminal procedure is the Criminal procedure code of the Russian Federation; judgment of the Constitutional Court of the Russian Federation can be recognized as sources of criminal procedural law only for the decision, and indirectly.
СТАНОВЛЕНИЕ ИНСТИТУТА АПЕЛЛЯЦИОННОГО ПРОИЗВОДСТВА
Creators: name: ТУРКИЕВ РАМАЗАН МАГОМЕДСАИДОВИЧ
name: СЕФИКУРБАНОВ КАЗИМАГОМЕД СЕФИКУРБАНОВИЧ
Publisher: name: Закон и право
Year: 2020
Subjects: АПЕЛЛЯЦИЯ
ИСТОРИЧЕСКОЕ РАЗВИТИЕ
УГОЛОВНОЕ СУДОПРОИЗВОДСТВО
АПЕЛЛЯЦИОННОЕ ПРОИЗВОДСТВО
ИНСТИТУТ ОБЖАЛОВАНИЯ
APPEAL
HISTORICAL DEVELOPMENT
CRIMINAL PROCEEDINGS
APPEAL PROCEEDINGS
INSTITUTE OF APPEAL

description: В статье излагается процесс возникновения и развития апелляции со времен Древнего Рима и в Средние века. Рассматривается процесс становления апелляции как комплексного уголовно-процессуального института в отечественном судопроизводстве. Описывается, как основные особенности апелляционного производства отражают его характерные черты. Отмечается значимость института апелляционного обжалования по уголовным делам как гаранта соблюдения ряда принципов уголовного судопроизводства.The article describes the process of emergence and development of appeal from the time of Ancient Rome and in the Middle ages. The article considers the process of formation of the appeal as a complex criminal procedure institution in the domestic legal proceedings. It describes how the main features of the appeal process reflect its characteristic features. The author notes the importance of the institute of appeal in criminal cases as a guarantor of compliance with a number of principles of criminal procedure.
Effects of demand characteristics in VVG research
Creators: name: Seetahul, Yashvin
name: Greitemeyer, Tobias
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: aggression
subject: demand characteristics
subject: violent video games

description: This project aims to investigate the effects of demand characteristics in violent video game research
Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the relaxin in acute heart failure (RELAX-AHF) development program: Correlation with outcomes
Creators: name: Marmor, Alon
name: Dorobantu, Maria
name: Schumacher, Christoph
name: Felker, G. Michael
name: Ponikowski, Piotr
name: Filippatos, Gerasimos
name: Bush, Christopher
name: Cotter, Gad
name: Trapani, Angelo
name: Edwards, Christopher
name: Prescott, Margaret
name: Werdan, Karl
name: Adams, Kirkwood
name: Severin, Thomas
name: Davison, Beth
name: Teerlink, John
name: Jondeau, Guillaume
name: Saini, Rajnish
name: Metra, Marco
name: Unemori, Elaine
name: Pang, Peter
name: Teichman, Sam
name: Voors, Adriaan
name: Greenberg, Barry
name: Masip, Josep
name: Grinfeld, Liliana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: OBJECTIVES: The aim of this study was to assess the effects of serelaxin on short-term changes in markers of organ damage and congestion and relate them to 180-day mortality in patients with acute heart failure. BACKGROUND: Hospitalization for acute heart failure is associated with high post-discharge mortality, and this may be related to organ damage. METHODS: The Pre-RELAX-AHF (Relaxin in Acute Heart Failure) phase II study and RELAX-AHF phase III study were international, multicenter, double-blind, placebo-controlled trials in which patients hospitalized for acute heart failure were randomized within 16 h to intravenous placebo or serelaxin. Each patient was followed daily to day 5 or discharge and at days 5, 14, and 60 after enrollment. Vital status was assessed through 180 days. In RELAX-AHF, laboratory evaluations were performed daily to day 5 and at day 14. Plasma levels of biomarkers were measured at baseline and days 2, 5, and 14. All-cause mortality was assessed as a safety endpoint in both studies. RESULTS: Serelaxin reduced 180-day mortality, with similar effects in the phase II and phase III studies (combined studies: N = 1,395; hazard ratio: 0.62; 95% confidence interval: 0.43 to 0.88; p = 0.0076). In RELAX-AHF, changes in markers of cardiac (high-sensitivity cardiac troponin T), renal (creatinine and cystatin-C), and hepatic (aspartate transaminase and alanine transaminase) damage and of decongestion (N-terminal pro-brain natriuretic peptide) at day 2 and worsening heart failure during admission were associated with 180-day mortality. Serelaxin administration improved these markers, consistent with the prevention of organ damage and faster decongestion. CONCLUSIONS: Early administration of serelaxin was associated with a reduction of 180-day mortality, and this occurred with fewer signs of organ damage and more rapid relief of congestion during the first days after admission.