cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Effect of Ascending and Descending Fartlek Training on the Development of Specific Speed for 3000 Meter Runners According to Target Time for Track and Field Youth Athletes
Creators: name: طنيبة ساعد
name: سعودي سليم
Publisher: name: Zenodo
Year: 2025
Subjects: Fartlek- Specific Speed- 3000 Meter Distance- Target Time- Youth Athletes

description: The objective of the study aims to identify the effect of ascending and descending fartlek training methods on the special speed of 3000-meter runners under 18 years old. For this purpose, we used the experimental method on a sample composed of 12 athletes, chosen purposively from track and field runners in Jijel. For data collection, we used physical fitness tests. After collecting the results and having treated them statistically using the SPSS statistical package, we concluded that both ascending and descending fartlek training methods positively affected the special speed of the runners, with significant statistical differences observed in favor of the experimental groups. On this basis, the study recommended the application of ascending fartlek training as an effective method for improving special speed in 3000-meter runners under 18 years old
The impact of Artificial Intelligence on teaching and learning in higher education
Creators: name: P, K
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 390305
subject: Professional education and training
classificationCode: 390308
subject: Technical, further and workplace education

description: Artificial Intelligence (AI) is reshaping higher education by enabling personalised learning experiences that adapt to individual student needs, preferences, and learning styles. Educators can deliver tailored content through AI-powered tools, provide real-time feedback, and support diverse learning pathways. It enhances both teaching efficiency and learner engagement by automating routine tasks and enabling data-driven decision-making. AI also fosters inclusive education by addressing learning gaps and supporting students with varying abilities. As AI continues to evolve, it holds the potential to transform higher education into a more flexible, adaptive, and student-centered ecosystem.
JHC768230_Supplemental_Material – Supplemental material for Depolarized Hepatocytes Express the Stem/Progenitor Cell Marker Neighbor of Punc E11 After Bile Duct Ligation in Mice
Creators: name: Bowe, Andrea
name: Zweerink, Susanne
name: Mück, Vera
name: Kondylis, Vangelis
name: Schulte, Sigrid
name: Goeser, Tobias
name: Nierhoff, Dirk
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Cell Biology
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, JHC768230_Supplemental_Material for Depolarized Hepatocytes Express the Stem/Progenitor Cell Marker Neighbor of Punc E11 After Bile Duct Ligation in Mice by Andrea Bowe, Susanne Zweerink, Vera Mück, Vangelis Kondylis, Sigrid Schulte, Tobias Goeser and Dirk Nierhoff in Journal of Histochemistry & Cytochemistry
Specific Inhibition Of Beta-Secretase Processing Of The Alzheimer'S Disease Amyloid Precursor Protein
Creators: name: L. Rajendran
Publisher: name: Zenodo
Year: 2016

description: Development of disease-modifying therapeutics is urgently needed for treating Alzheimer's disease (AD). AD is characterized by the toxic b-amyloid (Ab) peptides, produced by b-and g-secretases-cleavage of the amyloid precursor protein (APP). b-Secretase inhibitors reduce Ab levels, however mechanism-based side effects arise because they also inhibit b-cleavage of non-amyloid substrates like Neuregulin. We report that b-secretase has higher affinity for Neuregulin than APP. Kinetic studies demonstrate that the affinities and catalytic efficiencies of b-secretase are higher towards the non-amyloid substrates than APP. We show that non-amyloid substrates are processed by b-secretase in an endocytosis-independent manner. Exploiting this compartmentalization of substrates, we specifically target the endosomal b-secretase by an endosomally-targeted-b-secretase inhibitor, which blocked cleavage of APP but not non-amyloid substrates in many cell systems including induced pluripotent stem-cell (iPSC)-derived neurons. b-Secretase inhibitors can be designed to specifically inhibit the Alzheimer's process, enhancing their potential as therapeutics for AD without undesired side effects.
MPEC 2025-H201 : 2025 HB7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 HB7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Les politiques de cooperation au developpement et de l'aide humanitaire: est-ce que le traité étabilissant una constitution pour l'Europe signifie un vrai progrès?
Creators: name: Gonzalez Del Pino, Sivia
Publisher: name: My University
Year: 2005
Subjects: cooperation
European Union
development aid
humanitarian assistance

description: Second semester University: Université de Montpellier.
title: Dynamische Netzentgelte und ihre mögliche Ausgestaltung für Deutschland
Creators: name: Weidlich, Anke
name: Bublitz, Andreas
name: Fichtner, Wolf
name: Grimm, Gunter
name: Hagenmeyer, Veit
name: Helfer, Marcus
name: Herrmann, Martin
name: Hofmann, Rebecca
name: Jahn, Andreas
name: Löbbe, Sabine
name: Möst, Dominik
name: Neuhoff, Karsten
name: Staudt, Philipp
name: Tretter, Richard
name: Weißbach, Tobias
name: Zapf, Martin
Publisher: name: Albert-Ludwigs-Universität Freiburg
Year: 2025
Subjects: subject: 333

description: Die aktuelle Netzentgeltsystematik wird den Anforderungen eines zunehmend von erneuerbaren Energien geprägten Stromsystems immer weniger gerecht und steht daher derzeit auf dem Prüfstand. Dynamische Netzentgelte werden in dieser Debatte häufiger als wichtiger Reformbaustein genannt, allerdings fehlt es bislang an konkreten Konzepten für deren Ausgestaltung in Deutschland. Das vorliegende Papier schließt an diese Lücke an, indem es notwendige Voraussetzungen analysiert und mögliche Ausgestaltungsformen dynamischer Netzentgelte erörtert. Es soll damit einen fundierten und konstruktiven Beitrag zur Weiterentwicklung des Netzentgeltsystems in Deutschland leisten.
Supplementary document for Emulating the Deutsch-Josza algorithm with an inverse-designed terahertz gradient-index lens - 6532730.pdf
Creators: name: Blackwell, Ashley
name: Yahiaoui, Riad
name: chen, yi-haun
name: Chen, Pai-Yen
name: Searles, Thomas
name: Chase, Zizwe
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental
Supplementary Material, alves_online_appendix – Sharing Rare Attitudes Attracts
Creators: name: Alves, Hans
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplementary Material, alves_online_appendix for Sharing Rare Attitudes Attracts by Hans Alves in Personality and Social Psychology Bulletin
Open Research Position Statement
Creators: name: Open Research Steering Committee
Publisher: name: Apollo - University of Cambridge Repository
Year: 2025
Subjects: Open research

description: This Statement summarises the University’s approach to open research. It is aimed at all those at the University who are conducting, disseminating or supporting University research, either directly or indirectly. It sets out key principles for the conduct and support of open research at the University of Cambridge. The University encourages researchers (staff and students who are conducting research) to embed open research practices throughout the lifecycle of research projects and to make research outputs as open as possible, as closed as necessary.
R2_Table_S4 – Supplemental material for Proteomics detection of S100A6 in tumor tissue interstitial fluid and evaluation of its potential as a biomarker of cholangiocarcinoma
Creators: name: Sudarat Onsurathum
name: Ornuma Haonon
name: Porntip Pinlaor
name: Chawalit Pairojkul
name: Narong Khuntikeo
name: Raynoo Thanan
name: Sittiruk Roytrakul
name: Somchai Pinlaor
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Cell Biology
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, R2_Table_S4 for Proteomics detection of S100A6 in tumor tissue interstitial fluid and evaluation of its potential as a biomarker of cholangiocarcinoma by Sudarat Onsurathum, Ornuma Haonon, Porntip Pinlaor, Chawalit Pairojkul, Narong Khuntikeo, Raynoo Thanan, Sittiruk Roytrakul and Somchai Pinlaor in Tumor Biology
Targeting Peptides Versus Proteins By Vaccination: Size Matters
Creators: name: M.F. Bachmann
Publisher: name: Zenodo
Year: 2016

description: In contrast to passive immunization with monoclonal antibodies (mAbs), which recognize a single epitope on the target, active vaccination induces polyclonal antibody responses, potentially targeting multiple epitopes on the antigen. mAbs therefore cause a stabilization of soluble target proteins (as e.g. cytokines), as they increase the half-life of the bound antigen. In contrast, polyclonal antibodies cause formation of small immune complexes, resulting in elimination of the target antigen. This, however, is only possible for proteins but for peptides, as they are too small for multiple antibody binding. This talk will show clinical and preclinical examples of this mechanism and discuss potentially resulting safety and efficacy issues.
Supplemental Material, SC_4_Flow_Chart_1 - What Is Lean Management in Health Care? Development of an Operational Definition for a Cochrane Systematic Review
Creators: name: Rotter, Thomas
name: Plishka, Christopher
name: Adegboyega Lawal
name: Harrison, Liz
name: Sari, Nazmi
name: Goodridge, Donna
name: Flynn, Rachel
name: Chan, James
name: Fiander, Michelle
name: Poksinska, Bonnie
name: Willoughby, Keith
name: Kinsman, Leigh
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material, SC_4_Flow_Chart_1 for What Is Lean Management in Health Care? Development of an Operational Definition for a Cochrane Systematic Review by Thomas Rotter, Christopher Plishka, Adegboyega Lawal, Liz Harrison, Nazmi Sari, Donna Goodridge, Rachel Flynn, James Chan, Michelle Fiander, Bonnie Poksinska, Keith Willoughby, and Leigh Kinsman in Evaluation & the Health Professions
Supplementary document for Nanolaminate-based Antireflection Coatings for Enhanced Scratch and Tribological Performance - 6533221.pdf
Creators: name: Wang, Yu-Si
name: Yang, Chenying
name: Yuan, Wenjia
name: tingting, zheng
name: Liu, Yujie
name: chen, xiao
name: Zhang, Yueguang
name: Shen, Weidong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Supplementary_Table_5._GLP1 – Supplemental material for Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization
Creators: name: Pop, Raoul
name: Kong, Seong-Ho
name: Langlois, Allan
name: Marchegiani, Francesco
name: Shlomovitz, Eran
name: Legnèr, András
name: Bietiger, William
name: Pinget, Michel
name: Beaujeux, Rémy
name: Mutter, Didier
name: Marescaux, Jacques
name: Diana, Michele
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, Supplementary_Table_5._GLP1 for Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization by Raoul Pop, Seong-Ho Kong, Allan Langlois, Francesco Marchegiani, Eran Shlomovitz, András Legnèr, William Bietiger, Michel Pinget, Rémy Beaujeux, Didier Mutter, Jacques Marescaux and Michele Diana in Surgical Innovation
Recent Advances In Solid Phase Peptide Synthesis
Creators: name: P.D. White
Publisher: name: Zenodo
Year: 2016

description: Since its introduction by Merrifield half a century ago, solid phase peptide synthesis has evolved to become the enabling technology for the development of peptide therapeutics. Using modern methods, 100 - 1000s of peptides can be routinely synthesised in parallel for screening as leads for drug development and peptide APIs are produced in ton scale. In this talk I consider the state of art and report on recent advances to overcome remaining issues such as aspartimide formation, racemisation during the coupling of cysteine and histidine residues, introduction of PTMs, and the synthesis of peptide thioesters.
GAMIFIKATSIYA METAVERS VA KVEST TEXNOLOGIYALARI TA'LIMNING KELAJAGI
Creators: name: O'rinboyeva, Kumushoy
name: Maripova, Madinabonu
name: Abubakirova, SHohista
name: Zafarova, SHohsanam
Publisher: name: Zenodo
Year: 2025

description: Zamonaviy ta'lim jarayonida texnologik yutuqlar o'ziga xos o'rin tutmoqda. Gamifikatsiya, metavers va kvest texnologiyalari kabi innovatsion usullar talabalarning motivatsiyasini oshirish va ularni interfaol muhitga jalb qilish uchun samarali vositalar sifatida qo'llanilmoqda. Ushbu tezisda gamifikatsiya tamoyillari, metavers platformalarining potensiali va kvest texnologiyalarining ta'limdagi roli tahlil qilinadi. Natijada, bu usullar ta'lim jarayonini yanada samarali va mazmunli qilish uchun zarur vosita ekanligi isbotlanadi.
Supplementary_Appendices – Supplemental material for Who Do They Think They Are? Identity as an Antecedent of Social Activism by Institutional Shareholders
Creators: name: Sikavica, Katarina
name: Perrault, Elise
name: Rehbein, Kathleen
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, Supplementary_Appendices for Who Do They Think They Are? Identity as an Antecedent of Social Activism by Institutional Shareholders by Katarina Sikavica, Elise Perrault and Kathleen Rehbein in Business & Society
Supplementary Table 1 -Supplemental material for Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury
Creators: name: Kang, Xue-Jing
name: Chi, Ye-Nan
name: Chen, Wen
name: Liu, Feng-Yu
name: Cui, Shuang
name: Liao, Fei-Fei
name: Cai, Jie
name: Wan, You
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Aged Health Care

description: Supplemental material, Supplementary Table 1 for Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury by Xue-Jing Kang, Ye-Nan Chi, Wen Chen, Feng-Yu Liu, Shuang Cui, Fei-Fei Liao, Jie Cai and You Wan in Molecular Pain
Online_Supplementary_Table_1 – Supplemental material for Perceived Calling and Work Engagement Among Nurses
Creators: name: Arunas Ziedelis
Publisher: name: Figshare
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Online_Supplementary_Table_1 for Perceived Calling and Work Engagement Among Nurses by Arunas Ziedelis in Western Journal of Nursing Research
Engineering The Way To Selective Inhibition Of Human Nav1.7: A Target For Pain
Creators: name: S. Ahuja
Publisher: name: Zenodo
Year: 2016

description: Human voltage gated sodium (hNav) channels have been implicated in a multitude of debilitating cardiovascular and neurological disorders. The high degree of sequence identity shared by the nine human Nav channel isoforms present a significant challenge in designing selective channel blockers. These Nav channels also remain recalcitrant to high-resolution structural studies because of their dynamic and complex multi-domain architecture. By exploiting the established portability of the voltage-sensor domains (VSDs) and the evolutionary relationship between human and homotetrameric bacterial Nav channels, we have established a robust protein-engineering strategy that has allowed us first ever insights into the molecular structure of the fourth VSD (VSD4) domain from hNav1.7 in complex with isoform-selective small molecule antagonists.
hNav1.7 is essential for pain perception and hence serves as an attractive target for development of novel analgesics. GX-936 and related inhibitors bind to the activated state of VSD4, where their anionic aryl sulfonamide warhead engages the fourth arginine gating charge on the S4 helix. These antagonists inhibit Nav1.7 through a ?voltage sensor trapping? mechanism by opposing the deactivation of VSD4, which in turn stabilizes inactivated states of the channel. Our structure reveals non-conserved residues on the S2 and S3 helices of hNav1.7 (VSD4) that form key determinants of isoform selectivity. In addition, we have observed a unique tripartite phospholipid-antagonist-VSD4 interaction, which furthers the role of membrane bilayers in modulating ion channel function and pharmacology. Our results shed light on the molecular basis of voltage sensing and establish a structural blueprint to design selective Nav channel antagonists for treating pain and other diseases.
Supplementary Material, 4_-_Online_Data_Appendix_(REVISED) – The Benefits of Backlash: EU Accession and the Organization of LGBT Activism in Postcommunist Poland and the Czech Republic
Creators: name: O’Dwyer, Conor
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography
subject: 160607 International Relations
subject: FOS: Political science

description: Supplementary Material, 4_-_Online_Data_Appendix_(REVISED) for The Benefits of Backlash: EU Accession and the Organization of LGBT Activism in Postcommunist Poland and the Czech Republic by Conor O’Dwyer in East European Politics & Societies and Cultures
Protein Production - Dealing With The Unpredictable
Creators: name: D.J. McMillan
Publisher: name: Zenodo
Year: 2016

description: Often the first activity within a new project is the generation of protein reagents for assay development, antibody discovery or structural studies. This poses problems for the protein biochemist working within industry as we have to give a timeline for delivery and years of experience suggest that it is almost impossible to predict how long it will take to express and purify a protein. Using worked examples I will highlight the unpredictability of recombinant protein production and share details on the processes implemented at UCB to increase chances of success.
New Approaches In The Selection Of Candidate Therapeutic Binders With Calcium Dependent Fragment Assembly Separation Technology (Cd-Fast)
Creators: name: D.J. O'Connell
Publisher: name: Zenodo
Year: 2016

description: Successful isolation of protein molecules in their native state for purification and high throughput screening strategies is simplified with a stable, high affinity interaction between an affinity tag and a covalently immobilised affinity ligand. This interaction must be high affinity, stable and completely reversible to be useful. To engineer a stable high-affinity interaction that is fully reversible at neutral pH, in non-denaturing, buffer conditions we have engineered two protein fragments from calbindin D9k to bind each other with picomolar affinity in the presence of calcium with stable off rate characteristics enabling screening that can be completely regenerated with chelation of calcium. Purification of binder scaffolds including scFv, Fc fusions, and DARPins has proven to be highly effective with downstream assays such as high throughput surface plasmon resonance proving to be robust with targets and binders from crude expression lysates. In this talk I will discuss examples of this system and how it may be best utilised for new therapeutic discovery.
Development Of Ipsc-Based Assays For Drug Development In Neuroscience: Tauopathies As An Entry Point
Creators: name: A. Cabrera Socorro
Publisher: name: Zenodo
Year: 2016

description: Tau aggregation is the pathological hallmark that best correlates with the progression of Alzheimer's Disease (AD). The presence of neurofibrillary tangles (NFTs), formed of hyperphosphorylated tau, leads to neuronal dysfunction and loss, and is directly associated with the cognitive decline observed in AD patients. The limited success in targeting ?-amyloid pathologies has reinforced the hypothesis of blocking tau phosphorylation, aggregation and/or spreading as alternative therapeutic entry points to treat AD. Identification of novel therapies requires disease-relevant and scalable assays capable of reproducing key features of the pathology in an in vitro setting. Here we will present our work using induced pluripotent stem cells (iPSC) as a virtually unlimited source of human cortical neurons to develop a robust and scalable tau aggregation model compatible with high throughput screening (HTS). We have downscaled cell culture conditions to 384-well plate format and used matrigel to introduce an extra physical protection against cell detachment that reduces shearing stress and better recapitulates pathological conditions. We complemented the assay with AlphaLISA technology for the detection of tau aggregates in a high throughput-compatible format. The assay is reproducible across users and works with different commercially available iPSC-lines, representing a highly translational tool for the identification of novel treatments against tauopathies including AD. In addition, we will be presenting the current efforts made in Europe to validate and consolidate iPSC technology as a robust tool for biomedical research: the European Bank of iPSCs (EBiSC).
FAI746181-ICMJE – Supplemental material for Role of Subtalar Arthroscopy in Operative Treatment of Sanders Type 2 Calcaneal Fractures Using a Sinus Tarsi Approach
Creators: name: Park, Chul Hyun
name: Yoon, Doo Hyung
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110323 Surgery
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, FAI746181-ICMJE for Role of Subtalar Arthroscopy in Operative Treatment of Sanders Type 2 Calcaneal Fractures Using a Sinus Tarsi Approach by Chul Hyun Park and Doo Hyung Yoon in Foot & Ankle International
Long-Term Starspot Activity Of Some Chromospherically Active Rs Cvn And By Dra Stars
Creators: name: Kozhevnikova Alla
name: Alekseev Ilya
Publisher: name: Zenodo
Year: 2016
Subjects: active stars
spots
activity cycles

description: We present results of our long-term photometric observations of a sample of 15 chromospherically active BY Dra and RS CVn-type stars. Observations were carried out at a 70-cm telescope and multichannel photometer of Kourovka Astronomical Observatory of Ural Federal University and at a 1.25-m telescope of Crimean Astrophysical Observatory from 2003 to 2015 in Johnson B, V, R, I bands. We also use the previously published photometric data for all these stars to find the meaning of historical star’s brightness, that we assume as a brightness of unspotted photosphere. Using a renewed zonal spot model for spotted stellar photospheres we determined spot parameters for all observational seasons, as our as published ones, that were spanning almost over 45 years for some stars (e.g. CG Cyg, WY Cnc, EV Lac, V 1396 Cyg). It is shown that the spots were located at low and middle latitudes up to 58 deg., are cooler than the surrounding photosphere by 200 - 2000 K according to the spectral class. The spotted area varied from season to season, comprising 13%−47% of the surface area of the star. Almost half of the stars display drifts of their spots towards the equator and poles during certain time intervals; however, the speeds of the spots’ latitude drifts are lower than the analogous speeds for sunspots, by factors of 1.5–4, on average. Activity cycles lasting from 5 to 40 years have been determined or confirmed for majority of the studied stars. As a rule, cycles are expressed in synchronous variations of spot areas, spot latitudes and average photometric star’s brightness.
description: {"references": ["Strassmeier, K.G. 2009, A&A Rev., vol. 17, p. 251", "Berdyugina, S.V. 2005, Living Rev. Solar Phys., vol. 2, N8, p.1", "Ol\u0430h, K. et al. 2009, A&A, vol. 501, p.703"]}
LAP766909_Spanish_Translation – Supplemental material for Indigenous Peoples’ Right to Communication with Identity in Argentina, 2009–2017
Creators: name: Doyle, María Magdalena
name: Emilse Siares
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, LAP766909_Spanish_Translation for Indigenous Peoples’ Right to Communication with Identity in Argentina, 2009–2017 by María Magdalena Doyle and Emilse Siares in Latin American Perspectives
DS_10.1177_0363546518759674 – Supplemental material for Nonsurgical Treatments of Patellar Tendinopathy: Multiple Injections of Platelet-Rich Plasma Are a Suitable Option: A Systematic Review and Meta-analysis
Creators: name: Andriolo, Luca
name: Altamura, Sante Alessandro
name: Reale, Davide
name: Candrian, Christian
name: Zaffagnini, Stefano
name: Filardo, Giuseppe
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110323 Surgery
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, DS_10.1177_0363546518759674 for Nonsurgical Treatments of Patellar Tendinopathy: Multiple Injections of Platelet-Rich Plasma Are a Suitable Option: A Systematic Review and Meta-analysis by Luca Andriolo, Sante Alessandro Altamura, Davide Reale, Christian Candrian, Stefano Zaffagnini, and Giuseppe Filardo in The American Journal of Sports Medicine
Human Induced Pluripotent Stem Cell Derived Bronchial Epithelium To Model Primary Ciliary Dyskinesia
Creators: name: J. De Vos
Publisher: name: Zenodo
Year: 2016

description: Human induced pluripotent stem cells (iPSC) are obtained by reprogramming differentiated cells into pluripotency. They can differentiate in vitro into numerous, if not every, human cell type and are therefore a promising source of cells for normal and diseased organ modelling.
As a proof of concept that iPSC can model lung disease, we aimed to reproduce in vitro primary ciliary dyskinesia, a genetic disease that causes defects in the action of cilia of the respiratory tract. We reprogrammed human skin fibroblasts from a patient with primary ciliary dyskinesia using Sendai viruses expressing OCT4, SOX2, c-MYC and KLF4. Several iPSC clones were amplified, characterized and validated. These diseased iPSC were then differentiated into cells of the lung lineage by a 4 steps protocol. Definitive endoderm was obtained by adding Activin A in low serum concentration conditions. Anterior foregut endoderm was then induced by blocking TGF and BMP signaling, and lung progenitor cells by exposure to BMP4 and FGF10. Cells were further cultured in air liquid interface (ALI) conditions to promote the formation of bronchial epithelium. Analysis of the final epithelium shows the expression of several mRNAs from the airway lineage, such as NKX2.1, FOXJ1, MUC5A, and SFPTC. These results demonstrate the production of bronchial epithelial cells and lung cells from iPSC. Further characterization of this epithelium is underway to measure the extent of the differentiation, the proportion of each cell type obtained and the cilia activity.
title: Tough guys: The portrayal of hypermasculinity and aggression in televised police dramas
Creators: name: Scharrer, Erica
Publisher: name: University of Massachusetts Amherst
Year: 2001

description: Psychological research evidence reveals serious, harmful implications for the intersection of macho personality and criminal behavior in individuals. This content analysis examines that intersection as it occurs in television content. Three hundred twenty-one male characters from police and detective dramas from the 1970s through the 1990s were examined for their levels of hypermasculinity and antisocial behavior. Results find strong associations for all male characters between physical aggression/antisocial behaviors and hypermasculinity measured along three dimensions. "Bad guys" consistently rated higher than "good guys" for hypermasculinity, and "good guys" appeared to have become less hypermasculine over time.
Genome Editing In Human Stem Cells - Creation Of Novel And Relevant Models For Basic Research And Drug Discovery
Creators: name: M.A. Gerber
Publisher: name: Zenodo
Year: 2016

description: The development of induced pluripotent stem cells as disease models has enabled significant progress in drug discovery. Thanks to modern genome engineering technologies, patient-derived iPSCs can be altered to introduce or correct disease-related mutations, making ideal isogenic cell models. Precision genome editing also allows for tagging of endogenous alleles, even those not expressed in the pluripotent state. These modifications have proven extremely useful for high content analysis, high throughput screening, target validation, and more. Here we will provide an overview of genome editing strategies that can be applied to stem cell engineering. A survey of targeted integration will be presented, with a focus on integrated reporters and SNP introduction/correction. Additional criteria for successful completion of stem cell engineering projects will also be discussed.
DAAHCVGNTablesIFNmodified – Supplemental material for Immunosuppressive and antiviral treatment of hepatitis C virus–associated glomerular disease: A long-term follow-up
Creators: name: Fabrizi, Fabrizio
name: Aghemo, Alessio
name: Lampertico, Pietro
name: Fraquelli, Mirella
name: Cresseri, Donata
name: Moroni, Gabriella
name: Passerini, Patrizia
name: Donato, Francesca M
name: Messa, Piergiorgio
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, DAAHCVGNTablesIFNmodified for Immunosuppressive and antiviral treatment of hepatitis C virus–associated glomerular disease: A long-term follow-up by Fabrizio Fabrizi, Alessio Aghemo, Pietro Lampertico, Mirella Fraquelli, Donata Cresseri, Gabriella Moroni, Patrizia Passerini, Francesca M Donato, Piergiorgio Messa in The International Journal of Artificial Organs
Supplementary document for Backward multiplex coherent anti-Stokes Raman (CARS) spectroscopic imaging with electron-multiplying CCD (EM-CCD) camera - 6533546.pdf
Creators: name: MURAKAMI, YUSUKE
name: Yoshimura, Minami
name: Klement, W.J.
name: Oda, Atsuki
name: Sakamoto, Ryo
name: Yakabe, Miho
name: Matsumoto, Atsushi
name: Oketani, Ryosuke
name: Leproux, Philippe
name: Ikenouchi, Junichi
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Fig. S1, S2
COMO_Supplementary_Table_(1) – Supplemental material for A 12-month, multicenter, parallel group comparison of dexamethasone intravitreal implant versus ranibizumab in branch retinal vein occlusion
Creators: name: Bandello, Francesco
name: Augustin, Albert
name: Tufail, Adnan
name: Leaback, Richard
Publisher: name: SAGE Journals
Year: 2018
Subjects: Medicine

description: Supplemental material, COMO_Supplementary_Table_(1) for A 12-month, multicenter, parallel group comparison of dexamethasone intravitreal implant versus ranibizumab in branch retinal vein occlusion by Francesco Bandello, Albert Augustin, Adnan Tufail and Richard Leaback in European Journal of Ophthalmology
Supplemental material for Infections in hospitalized lupus nephritis patients: characteristics, risk factors, and outcomes
Creators: name: P Liu
name: H Z Tan
name: H Li
name: C C Lim
name: J C J Choo
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material for Infections in hospitalized lupus nephritis patients: characteristics, risk factors, and outcomes by P Liu, H Z Tan, H Li, C C Lim and J C J Choo in Lupus
Persicaria Miller
Creators: name: Li, Bo
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Polygonales
Polygonaceae
Persicaria

description: Diagnostic key of the taxa studied
1. Leaves with peppery taste; flowers monomorphic...................................................................................... P. hydropiper
- Leaves without peppery taste; flowers dimorphic ........................................................................................................ 2
2. Inflorescences uninterrupted; flowers small; tepals without glandular dots ...................................................................... P.jucunda
- Inflorescences usually interrupted at base; flowers large; tepals densely or sparsely golden punctuate ......................................... 3
3. Plants without special odor; stems, leaves and ocreae densely or sparsely appressed ...................................................... P. japonica
- Plants intensely odoriferous (just like Houttuynia Thumb.); stems, leaves and ocreae glabrous or pubescent................................ 4
4. Perennial herbs with developed rhizomes; leaf blades lanceolate or narrowly lanceolate, both surfaces glabrous or nearly glabrous; ocreae glabrous; achenes shiny, smooth .................................................................................................................. P. odorata
- Annual herbs; leaf blades ovate or ovate-lanceolate, rarely broadly lanceolate, both surfaces sparsely pubescent; ocreae densely pubescent; achenes opaque, densely pitted .......................................................................................................... P. wugongshanensis
description: Published as part of Li, Bo, 2014, Persicaria wugongshanensis (Polygonaceae: Persicarieae), an odoriferous and distylous new species from Jiangxi, eastern China, pp. 133-144 in Phytotaxa 156 (3) on page 142, DOI: 10.11646/phytotaxa.156.3.4, http://zenodo.org/record/5127800
Supplementary Tables - Supplemental material for Chronotypes and circadian timing in migraine
Creators: name: WPJ Van Oosterhout
name: EJW Van Someren
name: GG Schoonman
name: MA Louter
name: GJ Lammers
name: MD Ferrari
name: GM Terwindt
Publisher: name: SAGE Journals
Year: 2017
Subjects: subject: Neuroscience
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary Tables for Chronotypes and circadian timing in migraine by WPJ van Oosterhout, EJW van Someren, GG Schoonman, MA Louter, GJ Lammers, MD Ferrari and GM Terwindt in Cephalalgia
Intraspecific variation in the venom composition of wild Vipera berus from two English populations
Creators: name: Cunningham, Oliver
Publisher: name: Anglia Ruskin Research Online (ARRO)
Year: 2025

description: Intraspecific variation in snake venom composition (protein and peptide toxins) has been documented on numerous occasions, predominantly within the families Viperidae and Elapidae. Known sources of this variation include: snake age, size, sex, feeding ecology, population geography and abiotic ecological factors associated with changing seasons. Such variation has been studied before in venoms of the European adder (Vipera berus) from Eastern European and Russian populations. However, the venoms of wild, British V. berus and their potential variation have never been studied. Two potential sources of British V. berus venom variation were investigated (differing population geography/ecology and snake sex). The two ecologically distinct wild V. berus populations sampled in this study are located in the English counties of Staffordshire and Essex. Reverse Phase High Performance Liquid Chromatography (RP-HPLC) analysis was used in isolation to separate V. berus venoms into their respective components. Venom composition data analysis involved a combination of Multivariate Analysis (MVA) and hypothesis testing. Subsequent results revealed that venom components varied between all samples. Based on the MVA, some of this venom component variation is attributed to potentially differing population ecology. Hypothesis testing (nonparametric Mann Whitney U test) revealed that the abundance of venom components varied significantly with V. berus sex. Experience gained during this study’s venom collection field work and the results of RP-HPLC analysis will contribute to further research. This includes the search for pharmacologically active venom components, not only in V. berus but also other snake species. Furthermore, this study contributes to addressing whether or not there is the need for locality specific V. berus antivenom development. Knowledge of snake venom composition intraspecific variation being fundamental to antivenom design, production and administration.
DS_10.1177_2381468318761027 – Supplemental material for Comparing and Monitoring Risk-Adjusted Hospital Performance Measures: A Weighted Estimating Equations Approach
Creators: name: Barfoot, Patricia Cooper
name: R. Jock MacKay
name: Steiner, Stefan H.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, DS_10.1177_2381468318761027 for Comparing and Monitoring Risk-Adjusted Hospital Performance Measures: A Weighted Estimating Equations Approach by Patricia Cooper Barfoot, R. Jock MacKay and Stefan H. Steiner in MDM Policy & Practice
Bioprinted Tissue Models For Substance Evaluation
Creators: name: M. Rimann
Publisher: name: Zenodo
Year: 2016

description: The bioprinting technology allows the creation of three-dimensional (3D) tissues in an additive manufacturing process with spatial control of cells, bioactive materials and molecules and therefore reflects the inherent complexity of native tissues to a high degree.
As applied university we focus on industry-driven projects. We are developing bioprinting solutions in the fields of the cosmetic and pharma industry. The current bioprinting solution offers the following specifications: i) inkjet- and extruder-based printheads with temperature control for cell jetting and contact printing into well plates, ii) different cell-compatible printable matrices (bioinks), iii) a photopolymerization unit to crosslink bioinks at 365 nm and iv) a cell mixer to avoid cell sedimentation in the print cartridge while printing. For tissue generation alternating layers of bioink and cells are printed to produce a multi-layered 3D tissue construct.
In our aging population there is a huge demand for treatments of muscle-tendon related diseases. In an industry research project we are developing an all-in-one solution to produce and analyse printed in vitro muscle-tendon tissues in a customized well plate. Two posts in each well of the well plate will serve as anchor points to build muscle/tendon tissues. First, monocultures of primary human myoblasts and primary rat tenocytes were printed separately in a dumbbell-shape around the posts. After cell differentiation the myoblasts were stained positive for myosin heavy chain (MHC) and myotubes developed and for tendon the characteristic collagen I-distribution around the cell nuclei was detected. The printed muscle tissue is contracting on electrical stimulation and shows physiological functionality. The integration of electrodes in the well plates will allow electrical stimulation and subsequent read-out in the well plate.
Nephrotoxicity is a major cause for effective drugs not being marketed. In a precompetitive research project we are reproducing parts of the nephron the so called proximal tubulus. In preliminary experiments we printed the proximal tubule of the kidney seeded with proximal tubule epithelial cells to cultivate them under physiological flow conditions.
The development of standardized 3D in vitro tissue models combined with read-outs is a prerequisite for the future success of 3D tissues in substance testing and medicine in general.
Disclosure: Funding: CTI, Project Numbers: 14331.1, 16313.1, SNF No.: 20PC21_161566 / 1
Application Of Stem Cell Glycomics For Efficient Generation Of De Novo Ips Cell Lines Using Glycan Biomarkers
Creators: name: T. Satomaa
Publisher: name: Zenodo
Year: 2016

description: All human cells are covered with a glycocalyx made of glycan structures that are characteristic to the cell type. We have studied the glycome of many human stem cell types and differentiated cells with modern glycan analysis methods. Based on this pioneering stem cell glycomics research, we have discovered antibodies against pluripotency markers that specifically recognize glycans on the surface of emerging iPS cells. Automatization with magnetic bead selection and FACS has enabled us to replace the laborious manual phase of cell colony selection and passaging normally associated with iPS cell line generation. Increased efficacy has brought down the cost of iPSC generation so that swift generation of large numbers of iPS cell lines is possible. Further, isolation of the newly formed iPSCs at a time when the colonies are only starting to form considerably shortens the time of the process. The generated iPSC clones are then expanded and characterized with standard methods. We have demonstrated that the technology is robust and applicable to difficult-to-reprogram samples due to the isolation step that can efficiently capture the struggling iPS cells. Either fibroblasts or mononuclear blood cells are reprogrammed using Sendai virus based or episomal and traceless reprogramming vectors. The process is already xeno-free on all the other steps and reagents except for the antibodies used in the sorting, which can be replaced with xeno-free antibodies to form a completely GMP-compatible process. Thus, generation of pure iPS cell lines using glycan biomarkers may enable translation to also clinical applications in the future.

Disclosure: TS, JH and JS are co-founders of Glykos Finland Ltd. that has a business in iPSC generation (Medeina Cell Technologies).
title: From wise to foolish: The portrayal of the sitcom father, 1950s-1990s
Creators: name: Scharrer, Erica
Publisher: name: University of Massachusetts Amherst
Year: 2001

description: An exploratory content analysis of family-oriented sitcoms shows modern television fathers and working class television fathers are more likely to be portrayed foolishly than fathers of the past or fathers of higher socioeconomic classes. A sample of long-running and top rated domestic sitcoms from the 1950s through the 1990s is examined. A theoretical argument is made that the portrayal of sitcom fathers can be linked to changing social climates in which certain jokes become "fair game."
The effect of reperted hypoxic training on the maximum aerobic speed(vma)of U17 football players
Creators: name: لكحل سفيان
name: الصادق إسماعيل
Publisher: name: Zenodo
Year: 2025
Subjects: Repeated hypoxic training / Maximum aerobic speed (vma) / footballers U17

description: The Object of the study aims to identify impact of repeated hypoxic training on the maximum aerobic speed (VMA) of U17 football players. For this purpose, we used an experimental design simulating oxygen deficiency conditions by conducting training sessions indoors. On a sample composed of 20 players from the Rayed Challalet El Adaoura team in the second regional league Blida,it is divided into two groups: an experimental group undergoing hypoxic training and a control group, for data collection, we used a tool of the Luc-Leger test. After collecting the results and having treated them statistically, we conclude that the repeated hypoxic training significantly improved maximum aerobic speed among these players. On this basis, the study recommended the importance of this type of training in enhancing athletic performance in sports requiring advanced aerobic capacities such as football.
April_2018_ASR_media_abstracts_Wilmers – Supplemental material for Wage Stagnation and Buyer Power: How Buyer-Supplier Relations Affect U.S. Workers’ Wages, 1978 to 2014
Creators: name: Wilmers, Nathan
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, April_2018_ASR_media_abstracts_Wilmers for Wage Stagnation and Buyer Power: How Buyer-Supplier Relations Affect U.S. Workers’ Wages, 1978 to 2014 by Nathan Wilmers in American Sociological Review
Supplementary document for Different-Mode Power Splitters Based on a Multi-Dimension Direct-Binary-Search Algorithm - 6533633.pdf
Creators: name: Ma, Hansi
name: He, Xin
name: Zhu, Gangyi
name: Wu, Jia-Gui
name: Jiang, Xinpeng
name: Du, Te
name: Zhang, Zhaojian
name: Wang, yaorong
name: Wei, Wei Linyi
name: Zhang, Shumao
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplementary materials
Supplementary Table 1 -Supplemental material for Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy
Creators: name: R Pessato Timóteo
name: A Ferreira Silva
name: D Côbo Micheli
name: E F Candido Murta
name: M Freire
name: R Botelho Teodoro
name: F M Lima
name: B Martins Tavares Murta
name: D Bertoncello
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, Supplementary Table 1 for Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy by R Pessato Timóteo, A Ferreira Silva, D Côbo Micheli, E F Candido Murta, M Freire, R Botelho Teodoro, F M Lima, B Martins Tavares Murta and D Bertoncello in Lupus
Supplemental material for Extended negative binomial hurdle models
Creators: name: Maengseok Noh
name: Youngjo Lee
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111708 Health and Community Services
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material for Extended negative binomial hurdle models by Maengseok Noh and Youngjo Lee in Statistical Methods in Medical Research