cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modernizing Drug Substance Manufacturing: Continuous Crystallization in Traditional And Innovative Platforms
Creators: name: Liu, Yiqing
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Chemical engineering not elsewhere classified

description: Crystallization, the final isolation and purification step in many drug substance manufacturing processes, has substantial impact on downstream efficiency and possibly final drug product qualities. Currently, crystallization is largely carried out in batch which may suffers from batch-to-batch variations. Continuous crystallization is the missing key to end-to-end continuous manufacturing of oral solid dosage form pharmaceuticals. It is estimated that shifting from batch to continuous operations may help the pharmaceutical industry (1) reduce plant footprint, (2) decrease energy consumption and (3) spawn faster response to drug shortages. The overall aim of this thesis is to study and design continuous crystallization processes in both a traditional stirred tank crystallizer (STC) and a novel oscillatory baffle reactor (OBR). In the STC, the thesis aims to establish a systematic framework to model crystallization via a risk-based approach. This methodology considers the highly regulated nature of the pharmaceutical industry where an impactful model must be verified and validated carefully. The OBR on the other hand is a novel commercial platform in which continuous operations have never been established. Its performance was compared to the STC in terms of residence time distribution where OBR showed more uniform and consistent operation. A start-up study was then carried out to study different start-up strategies to examine their effects on process dynamics and steady state products. The last piece is to study the integration of continuous crystallization with continuous filtration which is not well studied in the current literature. A novel commercial continuous filtration unit, the continuous filtration carousel (CFC) was studied to construct a truly continuous drug substance separation step. The operating conditions were optimized based on filter capacity and filter efficiency studies with particles of different shapes. Continuous coupling of crystallization and CFC was successfully carried out based on the optimized conditions and a risk consideration discussion was given for process safety assessments.
Additional file 1 of Identifying knowledge deficiencies in genetics education among medical students and interns in Saudi Arabia- A cross-sectional study
Creators: name: Zakariyah, Abeer F.
name: Alamri, Sadin A.
name: Alzahrani, Manal M.
name: Alamri, Aseel A.
name: Khan, Muhammad A.
name: Hanbazazh, Mehenaz A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Carare - D3.5 Report On Europeana Gis Services And Archaeology/Architecture Site Data (Final)
Creators: name: Zakrajšek, Frank J.
name: Vodeb, Vlasta
name: Stare, Jurij
Publisher: name: Zenodo
Year: 2012
Subjects: Archaeology and Architecture
Digital Heritage
Geographic Information System (GIS)

description: The deliverable Report on Europeana GIS services and archaeology/architecture site data introduces the Europeana GIS services to the archaeology/architecture site data sector. The added value of the inclusion of geographic location data in Europeana is in the:

	browsing of Europeana efficiently through space and time,
	searching for content in a more user friendly way, without need to type geographical names,
	making it possible to discover overlapping cultural content at the same location but originating from different sources and at different times,
	mapping and visualization of the content,
	performing GIS calculations and simulations.

The objectives of this deliverable are:

	to inform content providers, aggregators, cultural institutions and others with geographic information services especially Europeana GIS services,
	to present the results of the initial testing Europeana GIS services,
	to give recommendations on a few topics such as co-ordinate systems and the INSPIRE directive when providing geographical data to aggregators,
	to investigate the potential for enriching the place-name services on the basis of geographical information contained in archeological and architectural inventories.
Additional file 1 of Exploring the factors impacting choice and quality of overnight private hospital stays and consumer perspectives on patient reported experience measures (PREMs) in Australia: a qualitative interview study
Creators: name: Verlis, Krista
name: McCaffery, Kirsten
name: Copp, Tessa
name: Dodd, Rachael
name: Laidsaar-Powell, Rebekah
name: Nickel, Brooke
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
sj-docx-1-msj-10.1177_13524585211028561 – Supplemental material for A smartphone sensor-based digital outcome assessment of multiple sclerosis
Creators: name: Montalban, Xavier
name: Graves, Jennifer
name: Midaglia, Luciana
name: Mulero, Patricia
name: Julian, Laura
name: Baker, Michael
name: Schadrack, Jan
name: Gossens, Christian
name: Ganzetti, Marco
name: Scotland, Alf
name: Lipsmeier, Florian
name: van Beek, Johan
name: Bernasconi, Corrado
name: Belachew, Shibeshih
name: Lindemann, Michael
name: Hauser, Stephen L
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-msj-10.1177_13524585211028561 for A smartphone sensor-based digital outcome assessment of multiple sclerosis by Xavier Montalban, Jennifer Graves, Luciana Midaglia, Patricia Mulero, Laura Julian, Michael Baker, Jan Schadrack, Christian Gossens, Marco Ganzetti, Alf Scotland, Florian Lipsmeier, Johan van Beek, Corrado Bernasconi, Shibeshih Belachew, Michael Lindemann and Stephen L Hauser in Multiple Sclerosis Journal
Additional file 1 of In vitro and in silico studies of enterobactin-inspired Ciprofloxacin and Fosfomycin first generation conjugates on the antibiotic resistant E. coli OQ866153
Creators: name: Khazaal, Mohamed T.
name: Faraag, Ahmed H. I.
name: El-Hendawy, Hoda H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1.
sj-pdf-2-trr-10.1177_03611981211025279 – Supplemental material for Travel Mode Choices in a Greening Market: The Impact of Electric Vehicles and Prior Investments
Creators: name: van Dijk, Jeremy
name: Farsi, Mehdi
name: Weber, Sylvain
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-2-trr-10.1177_03611981211025279 for Travel Mode Choices in a Greening Market: The Impact of Electric Vehicles and Prior Investments by Jeremy van Dijk, Mehdi Farsi and Sylvain Weber in Transportation Research Record
sj-docx-1-sci-10.1177_00368504211036133 – Supplemental material for A study on heat transfer load in large space buildings with stratified air-conditioning systems based on building energy modeling: Model validation and load analysis
Creators: name: Zhang, Yunqian
name: Lu, Jun
name: Jiang, Xin
name: Shen, Shuren
name: Wang, Xin
Publisher: name: SAGE Journals
Year: 2021
Subjects: Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-sci-10.1177_00368504211036133 for A study on heat transfer load in large space buildings with stratified air-conditioning systems based on building energy modeling: Model validation and load analysis by Yunqian Zhang, Jun Lu, Xin Jiang, Shuren Shen and Xin Wang in Science Progress
Additional file 1 of Liver abscess in the caudate lobe caused by Klebsiella pneumoniae: a rare case report and literature review
Creators: name: Cheng, Lingxia
name: Li, Lei
name: Liu, Yongzao
name: Cheng, Wei
name: Wang, Guan
name: Xu, Ping
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
Test Generation and Resynthesis Procedures for Test and Diagnosis Quality
Creators: name: Wang, Naixing
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Digital processor architectures
Other information and computing sciences not elsewhere classified

description: Testing and diagnosis are performed to detect and identify manufacturing failures in integrated circuits. In this dissertation, we focus on three important issues in test and diagnosis. The solutions to these issues are implemented using commercial EDA tools. No modification to the commercial tools is required. Thus, they can be easily applied to complex designs with state-of-the-art features. We first address overtesting of delay faults. Overtesting may occur when the circuit is brought into states that cannot be reached during functional operations. We address this issue by generating functional broadside tests using reachable states as scan-in states. Next, we address the issue of improving the resolution of multiple-defect diagnosis by ignoring certain tests. A feature of commercial defect diagnosis tools is used to avoid losing accuracy. Last, we address the issue of avoiding undetectable faults that model potential systematic defects caused by design-for-manufacturability (DFM) guideline violations in a cell-based design. We demonstrate that these undetectable faults tend to cluster in certain areas of the circuit, resulting in circuit areas with low coverage. The missing tests may allow detectable defects in these areas to escape detection. This can impact the defective-parts-per-million (DPPM) and reliability significantly since the defects are likely to be systematic. We address this issue in a cell-based design by eliminating the undetectable faults related to DFM guidelines that are internal and external to cells. We first propose a logic resynthesis procedure to eliminate large clusters of undetectable faults that are internal to cells. Next, we propose a layout resynthesis procedure that eliminates undetectable faults external to cells by making fine changes to the layout so as to fix the corresponding DFM guideline violations.
sj-pdf-2-jso-10.1177_23971983211033772 – Supplemental material for Genome-wide DNA methylation pattern in systemic sclerosis microvascular endothelial cells: Identification of epigenetically affected key genes and pathways
Creators: name: Nada, Shadia
name: Kahaleh, Bashar
name: Altorok, Nezam
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-2-jso-10.1177_23971983211033772 for Genome-wide DNA methylation pattern in systemic sclerosis microvascular endothelial cells: Identification of epigenetically affected key genes and pathways by Shadia Nada, Bashar Kahaleh and Nezam Altorok in Journal of Scleroderma and Related Disorders
КОРРУПЦИЯГА ОИД ҲУҚУҚБУЗАРЛИКЛАР ПРОФИЛАКТИКАСИДА ИЧКИ ИШЛАР ОРГАНЛАРИНИНГ ВАЗИФАЛАРИ
Creators: name: Хожиматов, Илхомжон
Publisher: name: Zenodo
Year: 2025

description: Мақола ички ишлар органларининг коррупцияга оид ҳуқуқбузарликлар профилактикасидаги вазифалари ва ролига бағишланган. Унда коррупциянинг ижтимоий-иқтисодий оқибатлари, унинг олдини олишда ички ишлар органлари томонидан қўлланиладиган усуллар ва қонунчийлик асослари кўриб чиқилади. Шунингдек, коррупцияга қарши курашишда ахборот технологиялари, таҳлилий усуллар ва жамоатчилик билан ҳамкорликнинг аҳамияти таъкидланади. Профилактика самарадорлигини ошириш учун замонавий ёндашувлар ва таклифлар таҳлил қилинади.
sj-pdf-2-cjk-10.1177_20543581211032857 – Supplemental material for Voicing Individual Concerns for Engagement in Hemodialysis (VOICE-HD): A Mixed Method, Randomized Pilot Trial of Digital Health in Dialysis Care Delivery
Creators: name: Thompson, Stephanie
name: Schick-Makaroff, Kara
name: Bello, Aminu
name: Tonelli, Marcello
name: Wiebe, Natasha
name: Buzinski, Robert
name: Courtney, Mark
name: Szigety, Susan
name: Shah, Nikhil
name: Bohm, Clara
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-2-cjk-10.1177_20543581211032857 for Voicing Individual Concerns for Engagement in Hemodialysis (VOICE-HD): A Mixed Method, Randomized Pilot Trial of Digital Health in Dialysis Care Delivery by Stephanie Thompson, Kara Schick-Makaroff, Aminu Bello, Marcello Tonelli, Natasha Wiebe, Robert Buzinski, Mark Courtney, Susan Szigety, Nikhil Shah and Clara Bohm in Canadian Journal of Kidney Health and Disease
sj-pdf-2-jpc-10.1177_21501327211034807 – Supplemental material for Customizing a Program for Older Adults Living with Frailty in Primary Care
Creators: name: Rasiah, Jananee
name: O’Rourke, Tammy
name: Dompé, Brian
name: Rolfson, Darryl
name: Mansell, Beth
name: Pereira, Rachel
name: Chan, Titus
name: McDonald, Karen
name: Summach, Anne
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-pdf-2-jpc-10.1177_21501327211034807 for Customizing a Program for Older Adults Living with Frailty in Primary Care by Jananee Rasiah, Tammy O’Rourke, Brian Dompé, Darryl Rolfson, Beth Mansell, Rachel Pereira, Titus Chan, Karen McDonald and Anne Summach in Journal of Primary Care & Community Health
Additional file 2 of In vitro and in silico studies of enterobactin-inspired Ciprofloxacin and Fosfomycin first generation conjugates on the antibiotic resistant E. coli OQ866153
Creators: name: Khazaal, Mohamed T.
name: Faraag, Ahmed H. I.
name: El-Hendawy, Hoda H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 2.
Synchronization of the bovine estrous cycle: Current and emerging opportunities
Creators: name: Thomas, Jordan
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2024
Subjects: estrous cycle
bovine
beef cattle

description: Controlling the bovine estrous cycle is a necessity if performing fixed-time artificial insemination or embryo transfer. Addition­ally, irrespective of the genetic objectives driving the decision to use reproductive technologies, the use of synchronization protocols often has beneficial effects on the overall reproduc­tive performance and commercial production output of a beef cattle operation. This proceedings paper provides a general review of the conceptual goals and challenges associated with synchronization of estrus, and directs readers to resources on current protocols and emerging opportunities in the field.
description: American Association of Bovine Practitioners Conference Proceedings, No. 57 (2024): 2024 Recent Graduate Conference Proceedings
Supplement Number 1
Creators: name: Wu, Hsin-Yeh
name: Besancon, Marc
name: Chen, Jia-Wern
name: Chen, Pisin
name: Glicenstein, Jean-François
name: Liu, Shu-Xiao
name: Lu, Yu-Jung
name: Navick, Xavier-Francois
name: paganis, Stathes
name: Tuchming, Boris
name: Tsionou, Dimitra
name: Tsai, Feng-Yang
Publisher: name: AIP Publishing
Year: 2025
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Supplementary Material
Effect of Climatic Changes on Subgrade Stiffness
Creators: name: Quiroga, Andrea Ardila
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Civil geotechnical engineering

description: There is consistent research evidence that shows improvement of the engineering properties of subgrade soils treated with lime or cement. However, limited information is available on the effect of climatic changes on the subgrade stiffness. The thesis studies the effects of changes in soil moisture content and temperature on the resilient modulus of treated and untreated subgrades in Indiana. Two types of soils were tested: A-6 and A-7-6, from two locations in Indiana: Hartford City and Bloomington, respectively. When existing standards ASTM D559/559-15 and ASTM D560/560-16 for wetting/drying (WD) and freezing/thawing (FT) processes, respectively, were followed, the treated and untreated samples failed through the process of preparation due to the stringent procedures in the standards. Appropriate test conditions were investigated, as part of the research, to develop new protocols more appropriate to the field conditions in Indiana. Two new test protocols were developed and successfully applied to the treated soils. A total of 26 resilient modulus, MR, tests were conducted following the standard AASHTO T307-99. The MR results showed that the repeated action of WD and FT cycles reduced the stiffness of the chemically-treated soils down to values similar to or lower than those of the untreated soils. However, when the amount of chemical was doubled, with respect to the optimum, the MR of the treated soils improved over that of the untreated soils, even after the wetting-drying cycles.
Additional file 1 of The application of health information technology for the elderly care in the emergency department: a conceptual model
Creators: name: Shagerdi, Ghazal
name: Ayatollahi, Haleh
name: Hemmat, Morteza
name: Zeraatkar, Kimia
Publisher: name: figshare
Year: 2024
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: Information Systems

description: Supplementary Material 1
CAUGHT IN THE MIDDLE: KENYA'S FOREIGN POLICY BETWEEN BEIJING AND TAIPEI
Creators: name: Smith, Emily Anne
Publisher: name: AYDEN JOURNAL
Year: 2025
Subjects: Kenya, economic evolution, political transition, multi-party system, democratic pluralism

description: Kenya's historical narrative is characterized by significant milestones, particularly in its economic and political realms. Economically, the country has undergone a remarkable evolution since gaining independence from British colonial rule in 1963. Initially reliant on agriculture, Kenya has diversified its economy over the years, embracing various sectors to foster growth and development. This transition reflects the nation's resilience and adaptability in navigating global economic shifts.

Politically, Kenya's journey has been equally intriguing, marked by pivotal shifts in governance structures. The adoption of a multi-party system in 1991 signified a significant departure from its previous political landscape, ushering in a new era of democratic pluralism. This transition underscores Kenya's commitment to political inclusivity and the promotion of democratic ideals.

This article endeavors to explore Kenya's dynamic historical trajectory, examining its economic diversification and political evolution. By delving into these dual narratives, the study seeks to uncover the underlying factors driving Kenya's development trajectory and the implications for its future trajectory. Understanding Kenya's historical context is essential for comprehending its present challenges and opportunities, offering valuable insights for policymakers, scholars, and stakeholders invested in the nation's socio-economic progress
Additional file 1 of Translation and measurement properties of pregnancy and childbirth questionnaire in Iranian postpartum women
Creators: name: Abdolalipour, Somayeh
name: Abbasalizadeh, Shamsi
name: Mohammad-Alizadeh-Charandabi, Sakineh
name: Abbasalizadeh, Fatemeh
name: Jahanfar, Shayesteh
name: Asghari Jafarabadi, Mohammad
name: Abdollahi, Kosar
name: Mirghafourvadsnd, Mojgan
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Reconfigurable Cavity Filters with Contactless Tuners
Creators: name: Abdelfattah, Mahmoud
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Wireless communication systems and technologies (incl. microwave and millimetrewave)

description: The recent development of tunable microwave filters has shown their great potential for being an integral component in future wireless systems across a wide range of applications. In the last decade, filters based on tunable evanescent-mode (EVA) cavity resonators have demonstrated a high performance with high quality factor (Q), wide tuning range and high power handling. However, the implementation of these filters suffers from reliability issues and integration complexity which restricted the practical utilization of these filters in different real-system applications. This dissertation will present and evaluate several practical and novel solutions to overcome these practical challenges without compromising the filter performance. The first part of the dissertation focuses on the design of quasi-absorptive bandstop filters with passive absolute bandwidth compensation utilizing micromachined cavity filters. The second part of the dissertation presents a novel method to tune substrate-integrated-waveguide (SIW) cavity filters using contactless tuners. In this work, a new tuning mechanism is proposed to overcome the mechanical reliability issues and the sensitive assembly of conventional tunable cavity filters. Furthermore, a new utilization of dual-mode SIW resonators is introduced in order to improve response selectivity and realize constant absolute bandwidth filters without compromising filter size and performance.
Supplemental Material, sj-pdf-3-tva-10.1177_15248380211030502 - Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis
Creators: name: Matsumoto, Maya
name: Piersiak, Hannah A.
name: Letterie, Mia C.
name: Humphreys, Kathryn L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-3-tva-10.1177_15248380211030502 for Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis by Maya Matsumoto, Hannah A. Piersiak, Mia C. Letterie and Kathryn L. Humphreys in Trauma, Violence, & Abuse
Additional file 1 of Upstream CtrA-binding sites both induce and repress pilin gene expression in Caulobacter crescentus
Creators: name: Rijal, Anurag
name: Johnson, Eli T.
name: Curtis, Patrick D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 1
2018 New Zealand Mental Health Monitor: Questionnaire
Creators: name: Health Promotion Agency, Te Hiringa Hauora |
Publisher: name: Health New Zealand
Year: 2024
Subjects: classificationCode: 420312
subject: Implementation science and evaluation

description: The New Zealand Mental Health Monitor (NZMHM) is a nationally-representative survey, conducted for the first time in 2015.This report is the questionnaire for the 2018 NZMHM which collected information about the mental health and wellbeing of New Zealand adults.
Supplemental Material, sj-docx-1-tva-10.1177_15248380211032213 - PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies
Creators: name: Dworkin, Emily R.
name: Jaffe, Anna E.
name: Bedard-Gilligan, Michele
name: Fitzpatrick, Skye
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-docx-1-tva-10.1177_15248380211032213 for PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies by Emily R. Dworkin, Anna E. Jaffe, Michele Bedard-Gilligan and Skye Fitzpatrick in Trauma, Violence, & Abuse
Additional file 1 of Non-contrast CT radiomics-clinical machine learning model for futile recanalization after endovascular treatment in anterior circulation acute ischemic stroke
Creators: name: Sun, Tao
name: Yu, Hai-yun
name: Zhan, Chun-hua
name: Guo, Han-long
name: Luo, Mu-yun
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
The Picturesque Domestication of Iran for an American Counter-Modern Retreat
Creators: name: Laga, Benjamin W
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Comparative and transnational literature

description: This thesis examines one of the most fraught and distorted relationships—the association between the United States and Iran. Contemporarily, most scholars and professionals associated with this connection evaluate the relationship in terms of politics, religion, power, and national security. Far fewer, however, evaluate it from its roots—the cultures, relationships, and dependencies that ultimately produced the prickly relationship of these two countries today. This thesis utilizes American authored travel narratives from 1921- 1941, written primarily by recreational travelers, to contradict American contemporary and paternalistic views of the relationship with Iran. This thesis posits that a nascent and unsure America depended on a pre-modern Iran to ease her into an impending modern existence.
title: The role of work-privacy conflict, work factors and leadership on the psychological well-being of general practice personnel
title: Results from the IMPROVEjob study
titleType: AlternativeTitle
Creators: name: Göbel, Julian
Publisher: name: Universitäts- und Landesbibliothek Bonn
Year: 2024
Subjects: subject: leadership
subject: work-privacy conflict
subject: work factors
subject: psychological well-being
subject: chronic stress
subject: burnout
subject: general practitioner
subject: primary care
subject: ddc:150
subject: ddc:610

description: Introduction:  Healthy general practitioners and their teams are a fundamental component of a functioning primary care system that facilitates a healthy and longer-living population. However, the mental health of this population is at risk as they suffer from high chronic stress in comparison with other occupational groups. Among the main predictors of this perceived chronic stress are work-privacy conflicts, challenging work demands and poor leadership quality. However, quantitative models for German general practitioners and their teams are lacking. The publications of this dissertation are based on a comprehensive model of stress among general practice personnel, a review of work-privacy conflict and leadership and its correlates, and the efficacy of the cluster-randomised controlled IMPROVEjob leadership trial.
 Methods:  This work draws on data from the IMPROVEjob study of German general practitioners and their teams with initially 60 general practices and 366 participants (84 practice leaders, 28 employed physicians, 254 practice assistants) at baseline. Perceived chronic stress, work-privacy conflict, work demands and leadership were assessed using validated questionnaires. Multilevel regression models and paired t-tests were used for statistical analysis.
 Results:  A quantitative model identifies high levels of work-privacy conflict, high quantitative work demands and poor leadership quality as factors associated with high perceived chronic stress among general practice personnel. Work-privacy conflict is particularly pronounced in practice leaders, and full-time employees are more likely to suffer from work-privacy conflict. According to the Leader-Member Exchange Theory, practice leaders and their employees have a good relationship quality. The IMPROVEjob intervention had no effect on job satisfaction but was rated very highly by the participants.
 Discussion:  The data show a need for strong leadership interventions in the general practice setting, as good leadership quality can have a positive influence on the psychological well-being of general practitioners and their teams. Reducing work-privacy conflict and work demands should also be targeted. Addressing these issues can have a positive impact on strengthening primary care, which in turn ensures better care for society.
A Pilot Investigation of an Instrument for the Assessment of Feeding Disorders in Children with Severe Disabilities
Creators: name: Norris, Annaliese E.
Publisher: name: University of Kentucky Libraries
Year: 2018
Subjects: subject: Speech Pathology and Audiology

description: The purpose of this pilot investigation was to assess the inter-rater reliability of an expert-validated pediatric feeding assessment, designed for clinician use with children who have severe disabilities. The tool would ideally allow for standardization of the clinical mealtime assessment process.

A comprehensive review of available feeding instruments revealed that there is a need for an assessment tool for children with motor and developmentally based feeding problems.In response to this need, a new clinician administered instrument called the Mealtime Assessment Tool for Children (MATCH) was developed in order to guide the assessment of a child during a clinical meal.

The items on the MATCH were selected based on expert validation of normal and abnormal feeding patterns that remain constant across the feeding assessments found in the literature. The tool includes a rating scale that allows for gradation of the severity of the problem. Child participants were taped while eating, and clips were rated by four SLPs using the MATCH. The resulting data was analyzed quantitatively, and it was found that across items there was a strong percentage agreement.
Additional file 1 of txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility
Creators: name: Zhang, Hao
name: Mulqueen, Ryan M.
name: Iannuzo, Natalie
name: Farrera, Dominique O.
name: Polverino, Francesca
name: Galligan, James J.
name: Ledford, Julie G.
name: Adey, Andrew C.
name: Cusanovich, Darren A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Fig S1. Collision rates of standard 10X protocol coupled with combinatorial indexing. Fig S2. Exponential amplification during GEM PCR enables deconvolution of cells in the same droplet. Fig S3. Evaluating the performance of txci-ATAC-seq on brain samples. Fig S4. Consistency of scATAC-seq mouse brain datasets. Fig S5. Quality metrics of txci-ATAC-seq in the native lung and liver samples with loading 100,000 or 200,000 nuclei. Fig S6. Cell type annotation of mouse lung samples. Fig S7. Cell type annotation of mouse liver samples. Fig S8. Cell type annotation of human lung sample with label transfer. Fig S9. Comparison of prediction accuracy between txci-ATAC-seq and sci-ATAC-seq in mouse lung cells. Fig S10. Characterization of cellular heterogeneity in human lung tissue. Fig S11. txci-ATAC-seq are robust to batch effects. Fig S12. Comparison of txci-ATAC with dsciATAC using a bead-merging strategy. Fig S13. Phased-txci-ATAC-seq improves multiplexing capability without sacrificing data quality. Fig S14. Chromatin accessibility changes induced by CC16-/- deficiency in mouse lung. Fig S15. Functional analysis and regulatory variant identification in CC16 deficient mouse. Fig S16. SNP-driven differences in motif usage alter chromatin accessibility. Fig S17. Comparison of empirical and theoretical cell recovery between molecular and cellular hashing strategies. Fig S18. Examination of efficiency for in-droplet and sample index PCR.
Additional file 1 of A qualitative approach to assess the opinion of physicians about the challenges and prospects of pharmacogenomic testing implementation in clinical practice in Greece
Creators: name: Koufaki, Margarita-Ioanna
name: Patrinos, George P.
name: Vasileiou, Konstantinos Z.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Impact of Antimicrobial Carcass Washes on Beef Trim Quality in the Production of Beef Frankfurters
Creators: name: Ford, Emily A
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Animal production not elsewhere classified

description: This objective of this study was to determine the impact of antimicrobial carcass washes on beef trim quality in the production of frankfurters. Twenty-four beef carcasses were randomly applied a different antimicrobial wash treatments (TRT) during the harvest procedure: 82° C water (CON), peroxyacetic acid (PAA), or lactic acid (LA). Beef carcasses were analyzed for microbial counts and carcass pH. Frankfurters were produced using carcass trim at two different batter temperature processes (PROC): 4°C (CP) or 21°C (HP). Frankfurters were analyzed for cook loss, emulsion stability (ES), color (Minolta L*, a*, b*) over 60-day storage, purge loss, texture, and sensory analysis. LA carcass had a lower pH (6.36; P<0.001) 30 min post wash compared to other wash treatments. Frankfurters produced from CON trim had the highest ES water (P<0.0001) and ES fat (P<0.0001) separation where the LA and PAA treatments were not significantly different (P>0.05). The HP frankfurters had less ES water (P<0.0001) and ES fat separation (P<0.0001) when compared to CP. However, the CP had a higher cook yield (P=0.002). The HP frankfurters had higher internal and external L* values (PPPPPP=0.004), a decrease in cohesiveness (P=0.03) and an increase in juiciness (PP=0.009) and chewiness (P=0.01) results showed the CON frankfurters were significantly harder than PAA (P<0.05), while LA were not different from CON or PAA frankfurters (P>0.05). The CP frankfurters were found to have a decrease in springiness (P=P=0.03). There was a significant difference in microbial reduction of pre to post wash petri film counts for all treatments (Log10CFU/mL) of aerobic plate count (P= <0.0001), E.coli coliform (P= 0.0002), yeast (P=0.04) and mold (P= <0.001). TRT was found to be significant for APC (P=0.06) and yeast (P=0.004). Overall, our research indicated antimicrobial wash treatments have little effect on frankfurter quality and displayed viable methods for reducing microbial growth on beef carcasses.
Targeting of Suppressive Myeloid Cells via Small Molecule Immunomodulators
Creators: name: Kischuk, Erin M
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Cellular immunology

description: Suppressive myeloid cells including myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), are a significant barrier to cancer immunotherapy. These cells enhance tumor growth and metastasis and promote immune escape by suppressing the anti-tumor T cell response. One of the key mechanisms of suppression is the production of nitric oxide (NO) via iNOS which leads to the modification and inactivation of various proteins involved in T cell effector function. Previous efforts to control suppressive myeloid cells have included direct elimination, blockade of accumulation or function at the tumor site, and conversion to an anti-tumor phenotype. Unfortunately, though several strategies have been tested in preclinical models and in clinical trials, there are currently no approved and effective therapies that are selective for these cells. The discovery of new drugs for these cells is hampered by the limited availability of primary cells for screening. The studies herein describe efforts to develop effective immunotherapies that target suppressive myeloid cells more specifically. Using a specific receptor, FRβ, combined with photodynamic therapy we were able to deplete MDSC and TAM from solid tumors. This strategy limits the cytotoxic effects to the target cells within the tumor site. We also pursued a strategy of targeting accumulation and/or suppressive function via testing of GCL.2, a compound expected to reduce the accumulation of MDSC at the tumor site. Finally, we targeted the NO production pathway using synthetic small molecules. Importantly, we did not target iNOS directly but utilized a computer-based model that analyzed the interactions of compounds with a large set of putatively overexpressed targets in suppressive MDSC. Experimental data was integrated into the model to refine additional selections. With this approach, we were able to identify several hit compounds and verified the immunomodulatory activity of one compound in vivo. These studies demonstrate that targeting the suppressive phenotype is a viable approach to cancer immunotherapy, and we have also validated a novel approach to drug discovery for suppressive myeloid cells.
SÍR ISLEP SHÍǴARÍWDA QOLLANÍLATUǴÍN SHIYKI ZATLAR  HÁM  TÚRLERI
Creators: name: Pirjanova, Shaxnoza
Publisher: name: Zenodo
Year: 2024

description: Maqalada sır ónimleriniń túrleri hám qollanılatuǵın shiyki zatlar, qosımshalar sonıń menen sırlardıń quramı keltirilgen. Sırlarda belok (25% ke shekem), sút mayı (60% ke shekem) hám mineral zatlardıń (3,5% ke shekem, as duzın esapqa almaǵanda) kópligi menen ajıralıp turadi. Sır ónimleriniń  belokları sút beloklarına qaraganda organizm tárepinen jaqsı ózlestiriledi. Sırlardaǵı ekstraktiv zatlar as siniriw bezlerine unamlı tásir kórsetedi, ishteydi ashadı. Sırdıń quramındaǵı azıqlıq zatlar organizm tárepinen derlik tolıq 98 - 99% ózlestiriliwi haqqında maǵlıwmatlar berilgen.
Additional file 1 of Risk factors of mortality in patients with rheumatoid arthritis-associated interstitial lung disease: a single-centre prospective cohort study
Creators: name: Song, Yeo-Jin
name: Kim, Hyoungyoung
name: Cho, Soo-Kyung
name: Kim, Hye Won
name: Lim, Chaewhi
name: Nam, Eunwoo
name: Choi, Chan-Bum
name: Kim, Tae-Hwan
name: Jun, Jae-Bum
name: Bae, Sang-Cheol
name: Yoo, Dae Hyun
name: Hong, Su Jin
name: Yoo, Seung-Jin
name: Lee, Youkyung
name: Sung, Yoon-Kyoung
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
The Effect of Reflection on Narrative Writing Ability of Low- and High-Achieving Students
Creators: name: Cianci, Kirsten
Publisher: name: Maryland Shared Open Access Repository
Year: 2017
Subjects: subject: Education -- Research papers (Graduate).

description: There has long been an argument going on in the field of education about the nature of learning, pitting the importance of what students learn against how students learn, or the content versus the process. Recent years have shown a boost in research on metacognition, including a focus on metastrategic knowledge and metacognitive knowledge monitoring. This study looks at a form of metacognition – reflection – to examine its potential correlation to narrative writing ability in low- and high-achieving 10th grade students at an all-girls school. The short nature of the study opened up many questions about the impact of reflection in the classroom and whether its effectiveness might be correlated to time spent or explicit teaching and what areas other than narrative writing might benefit from the use of reflection. In the future, the study should be continued over a lengthier time frame.
STEM AND DATA: INSTRUCTIONAL DECISION MAKING OF SECONDARY SCIENCE AND MATHEMATICS TEACHERS
Creators: name: Johns, Gary Lee
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Curriculum and pedagogy not elsewhere classified

description: This research is focused on the intersection of secondary teachers’ data-use to inform instructional decisions and their teaching of STEM in STEM-focused high schools. Teaching STEM requires presenting more than just the content knowledge of the STEM domains. The methods of inquiry (e.g., scientific inquiry, engineering design) are skills that should be taught as part of STEM activities (e.g., science labs). However, under the data- and standards-based accountability focus of education, it is unclear how data from STEM activities is used in instructional decision-making. While teachers give tremendous weight to the data they collect directly from their observations of their classrooms, it is data from standardized testing that strongly influences practices through accountability mandates. STEM education alters this scenario because, while there is a growing focus on teaching STEM, important aspects of STEM education are not readily standardized. This mixed-methods study will examine the perspectives of 9th through 12th grade science and mathematics teachers, in STEM-focused schools, on data-use and STEM teaching. We developed a framework, adapted from existing frameworks of data-use, to categorize these perspectives and outline contexts influencing them. Through a concurrent triangulation design we will combine quantitative and qualitative data for a comprehensive synthesis of these perspectives.
Is the impact of childhood influenza vaccination less than expected: a transmission modelling study
Creators: name: Weidemann, Felix
name: Remschmidt, Cornelius
name: Buda, Silke
name: Buchholz, Udo
name: Ultsch, Bernhard
name: Wichmann, Ole
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: Influenza
subject: Bayesian inference
subject: childhood vaccination
subject: transmission model
subject: NNV
subject: 610 Medizin

description: Background: To reduce the burden of severe influenza, most industrialized countries target specific risk-groups with influenza vaccines, e.g. the elderly or individuals with comorbidities. Since children are the main spreaders, some countries have recently implemented childhood vaccination programs to reduce overall virus transmission and thereby influenza disease in the whole population. The introduction of childhood vaccination programs was often supported by modelling studies that predicted substantial incidence reductions. We developed a mathematical transmission model to examine the potential impact of childhood influenza vaccination in Germany, while also challenging established modelling assumptions. Methods: We developed an age-stratified SEIR-type transmission model to reproduce the epidemic influenza seasons between 2003/04 and 2013/14. The model was built upon German population counts, contact patterns, and vaccination history and was fitted to seasonal data on influenza-attributable medically attended acute respiratory infections (I-MAARI) and strain distribution using Bayesian methods. As novelties we (i) implemented a stratified model structure enabling seasonal variability and (ii) deviated from the commonly assumed mass-action-principle by employing a phenomenological transmission rate. Results: According to the model, by vaccinating primarily the elderly over ten seasons 4 million (95% prediction interval: 3.84 – 4.19) I-MAARI were prevented which corresponds to an 8.6% (8.3% – 8.9%) reduction compared to a no-vaccination scenario and a number-needed-to-vaccinate (NNV) to prevent one I-MAARI of 37.1 (35.5 – 38.7). Additional vaccination of 2-10 year-old children at 40% coverage would have led to an overall I-MAARI reduction of 17.8% (17.1 – 18.7%) mostly due to indirect effects with a NNV of 20.7 (19.6 – 21.6). When employing the traditional mass-action-principle, the model predicted a more than 3-fold higher I-MAARI reduction (55.6%) due to childhood vaccination. Conclusion: In Germany, the introduction of routine childhood influenza vaccination could considerably reduce I-MAARI among all age-groups and improve the NNV. However, the predicted impact is much lower compared to previous studies, which is primarily caused by our phenomenological approach to modelling influenza virus transmission.
Trophic ecology and habitat occupancy of yellow perch in nearshore Lake Michigan and Saginaw Bay, Lake Huron
Creators: name: Senegal, Taylor J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Fisheries sciences not elsewhere classified

description: Elucidation of habitat and resource use patterns is important for facilitating sustainable management of fisheries. Discrete habitats in large aquatic ecosystems may offer distinct resources and differentially affect performance. Movement of organisms and organic materials links these habitats and potentially leads to spatially complex trophic pathways between basal resources and consumers. Habitat and resource use are commonly explored via two common methods: stable isotopes and morphometric analysis. The first research chapter of this thesis employed both methods to investigate seasonal habitat use of yellow perch Perca flavescensin eastern Lake Michigan and connected waterbodies known as drowned river mouth (DRM) lakes. Landmark-based geometric morphometrics was used to compare shape differences among habitats. Stable isotopes of ambient water, otoliths, and soft tissues were compared to differentiate among habitats. Both methods provided evidence of resident nearshore Lake Michigan fish, resident DRM lake fish occupying the littoral zone, and transient Lake Michigan fish occupying the profundal zone of DRM lakes. The majority of transient Lake Michigan fish moved into the profundal zone of DRM lakes in the fall. These results support previously published genetic data of distinct populations of yellow perch in eastern Lake Michigan and connected waterbodies. The second research chapter of this thesis also employed stable isotopes and morphometric analysis, but to investigate the consistency of resource use of age-0 yellow perch in Saginaw Bay, Lake Huron. These methods served as long-term diet indicators, as compared to short-term stomach contents analysis. Both stable isotopes of soft tissues and morphometric analysis showed spatial consistency in variation among sites. Fish from the two sites closer to the tributary input had higher δ15N values and more fusiform bodies, while fish from the third site further away from the tributary had lower δ15N values and were deeper-bodied. This spatial variation supports stomach content analysis of age-0 yellow perch from a previously published study. δ13C ratios displayed annual variation, and while inconsistent with stomach content analysis, was consistent with available prey items. The findings from this study suggest that young yellow perch in Saginaw Bay have limited movement and forage in a similar area to where they were collected. Previous studies have found discrepancies among indicators and have cautioned generalization of trophic relationships when only relying on a single metric. Agreement between complementary techniques provided additional support to previously-published genetic results and stomach content data, and thereby helped more fully describe habitat use by yellow perch in these systems.