cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation into the role of La/SS-B in Interferon regulation and its relevance in health and human disease
Creators: name: Mahony, Rebecca G.
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: The La/SS-B protein is well documented as an autoantigen for autoimmune conditions such as systemic lupus erythematosus (SLE). Recently, a link between La and viruses has been reported, an interesting observation given the fact that viral infection is a significant risk factor in SLE. However, the direct mechanism by which La functions in the innate immune response to viral challenge remains elusive. As such, we sought to investigate whether La directly regulates the induction of the anti-viral cytokines, type I Interferons, (IFNs) by direct modulation of innate immune toll-like receptor (TLR) or RIG-I-like receptor (RLR) signalling pathways. Our findings have highlighted a dual and complex role for La in the regulation of IFN production. Initial studies demonstrated a role for La in the specific attenuation of IFN promoter transcriptional activity downstream of RLR activation. In confirmation of this, elevated IFN levels were observed following La knockdown in resting cells, compared with controls. Studies in a cohort of SLE patients supported these findings, with decreased La expression observed in SLE patients compared with healthy controls in basal cells, both at an mRNA and protein level. However upon activation of the anti-viral RIG-I receptor, La was shown to promote anti-viral responses by direct interaction with RIG-I receptor, enhancing complex formation between RIG-I and its ligand as well as downstream adaptor protein IPS-1, the overall consequence of which was increased IFN induction. Sendai virus infection experiments supported these findings with depletion of La leading to increased viral infection efficiency and decreased IFN and IFN stimulated gene (ISG) expression. Thus a dual role exists for La in the context of RIG-I-mediated IFN production, with the protein capable of both inhibiting basal type I IFN in resting cells, most likely in an attempt to prevent inappropriate IFN induction and maintain innate immune balance. In the context of infection, however, La is a potent activator of IFN responses, promoting RIG-I binding to its ligand and enhanced type I and type III IFN production, in an effort to protect the host by limiting viral replication and promoting the clearance of the pathogen. Interestingly, we have observed that phosphorylation of La by casein kinase 2 (CK2) may be the regulatory switch that turns La from being active to inactive, and that in cells treated with a CK2-specific inhibitor, La has a higher affinity for RIG-I. With respect to a potential involvement of this protein in SLE we have observed that a higher ratio of expression of a potentially active form of La (neo-La) is observed in SLE patients, suggesting that this imbalance between full length and neo-La in SLE patients contributes to the dysregulated IFN expression observed in patients. Our work has important implications for our understanding of pathways regulating IFN production in the context of SLE.
Direct Numerical Simulation of structural vacillation in the transition to geostrophic turbulence
Creators: name: Randriamampianina, Anthony
name: Maubert, Pierre
name: Fruh, Wolf-Gerrit
name: Read, Peter L.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Geophysics (physics.geo-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The onset of small-scale fluctuations around a steady convection pattern in a rotating baroclinic annulus filled with air is investigated using Direct Numerical Simulation. In previous laboratory experiments of baroclinic waves, such fluctuations have been associated with a flow regime termed Structural Vacillation which is regarded as the first step in the transition to fully-developed geostrophic turbulence.
description: 6 pages
title: Chairs Checklist for Shared Decision Making
Creators: name: Kanelee, Ember Skye W.
name: Mickey, Ethel L.
name: Smith-Doerr, Laurel
Publisher: name: University of Massachusetts Amherst
Year: 2022

description: UMass ADVANCE survey results indicate that women faculty are less clear on personnel processes than men, and women faculty members from underrepresented racial minority groups are the least clear on tenure and promotion processes. This checklist is for department chairs/heads to assess departmental shared decision-making and create equitable practices that will support the inclusion and retention of women faculty and faculty of color.
Peptide Modified Probes and Surfaces for Protein Sensing and Platelet Capture
Creators: name: Adamson, Kellie
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Integrin αIIbβ3 is the central protein in haemostasis and thrombosis; its activation is the first step in a cascade of biochemical processes which leads to platelet activation, spreading and clotting. The mechanism of integrin activation and molecular details of platelet activation are still being worked out so tools which aid in this process are useful in both diagnostic and therapy development. Many questions remain on the conformational changes in the key integrin responsible for stimulating thrombosis and methods of preventing or forcing adhesion of platelets on solid surfaces is key in medical devices and diagnostics respectively. This work exploits the RGD peptide sequence (recognises fibrinogen which plays a key role in platelet activation), for both exploring conformational status of αIIbβ3 integrin in solution and tracking it in platelets and also for binding and releasing platelets from substrates. The former focusses on novel ruthenium(II) polypyridyl metal complex probes with long luminescent lifetimes which through changes to their photophysics and anisotropy can be used to determine the activation status of an integrin. In addition, the application of two stokes shifted probes: ruthenium(II) polypyridyl complexes, developed in this programme and also a near infra-red BODIPY in neurological tissue imaging is reported. Ru(II)binding to β-amyloid protein aggregates (linked to Alzheimer’s disease) is also presented, proving that the application of ruthenium complexes in biology is diverse, presenting huge potential in a wide variety of areas including tissue imaging and diagnostics. The latter focusses on novel means of binding or preventing binding of human blood platelets to planar or nanostructured surfaces which through chemical or geometrical modifications can be used to alter the binding ability, morphology and activation status of platelets, an aspect which is vital towards managing thrombus related diseases. Overall, this thesis introduces some new probes and tools which may have significant value and insight to offer in study and prevention of thrombosis.
A Factoid Question Answering System for Vietnamese
Creators: name: Le-Hong, Phuong
name: Bui, Duc-Thien
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: In this paper, we describe the development of an end-to-end factoid question answering system for the Vietnamese language. This system combines both statistical models and ontology-based methods in a chain of processing modules to provide high-quality mappings from natural language text to entities. We present the challenges in the development of such an intelligent user interface for an isolating language like Vietnamese and show that techniques developed for inflectional languages cannot be applied "as is". Our question answering system can answer a wide range of general knowledge questions with promising accuracy on a test set.
description: In the proceedings of the HQA'18 workshop, The Web Conference Companion, Lyon, France
Zipf's Law and Avoidance of Excessive Synonymy
Creators: name: Manin, Dmitrii
Publisher: name: arXiv
Year: 2007
Subjects: subject: Computation and Language (cs.CL)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Zipf's law states that if words of language are ranked in the order of decreasing frequency in texts, the frequency of a word is inversely proportional to its rank. It is very robust as an experimental observation, but to date it escaped satisfactory theoretical explanation. We suggest that Zipf's law may arise from the evolution of word semantics dominated by expansion of meanings and competition of synonyms.
description: 47 pages; fixed reference list missing in v.1
A Comparison of Cosmological Hydrodynamic Codes
Creators: name: Kang, Hyesung
name: Ostriker, Jeremiah P.
name: Cen, Renyue
name: Ryu, Dongsu
name: Hernquist, Lars
name: Evrard, August E.
name: Bryan, Greg L.
name: Norman, Michael L.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a detailed comparison of the simulation results of various cosmological hydrodynamic codes. Starting with identical initial conditions based on the Cold Dark Matter scenario for the growth of structure, we integrate from redshift $z=20$ to $z=0$ to determine the physical state within a representative volume of size $L^3$ where $L=64 h^{-1} {\rm Mpc}$. Five independent codes are compared: three of them Eulerian mesh based and two variants of the Smooth Particle Hydrodynamics "SPH" Lagrangian approach. The Eulerian codes were run at $N^3=(32^3,~64^3,~128^3,~{\rm and},~256^3)$ cells, the SPH codes at $N^3= 32^3$ and $64^3$ particles. Results were then rebinned to a $16^3$ grid with the expectation that the rebinned data should converge, by all techniques, to a common and correct result as $N \rightarrow \infty$. We find that global averages of various physical quantities do, as expected, tend to converge in the rebinned model, but that uncertainties in even primitive quantities such as $\langle T \rangle$, $\langle ρ^2\rangle^{1/2}$ persists at the 3\%-17\% level after completion of very large simulations. The two SPH codes and the two shock capturing Eulerian codes achieve comparable and satisfactory accuracy for comparable computer time in their treatment of the high density, high temperature regions as measured in the rebinned data; the variance among the five codes (at highest resolution) for the mean temperature (as weighted by $ρ^2$) is only 4.5\%. Overall the comparison allows us to better estimate errors, it points to ways of improving this current generation of hydrodynamic codes and of suiting their use to problems which exploit their individually best features.
description: 20p plaintex to appear in The Astrophysical Journal on July 20, 1994
Photonic glass for high contrast structural color
Creators: name: Shang, Guoliang
name: Maiwald, Lukas
name: Renner, Hagen
name: Jalas, Dirk
name: Dosta, Maksym
name: Heinrich, Stefan
name: Petrov, Alexander Yu.
name: Eich, Manfred
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Non-iridescent structural colors based on disordered arrangement of monodisperse spherical particles, also called photonic glass, show low color saturation due to gradual transition in reflectivity. No significant improvement is usually expected from particles optimization, as the Mie resonances are broad for small dielectric particles with moderate refractive index. Moreover, the short range order of a photonic glass alone is also insufficient to cause sharp spectral features. We show here, that the combination of a well-chosen particle geometry with the short range order of a photonic glass has strong synergetic effects. We demonstrate how core-shell particles can be used to obtain a sharp transition in the reflection spectrum of photonic glass which is essential to achieve a strong color saturation. The Fourier transform required for a highly saturated color can be achieved by shifting the first zero position of the motif Fourier transform to smaller wave numbers in respect to the peak of the lattice Fourier transform. We show that this can be obtained by choosing a non-monotonous refractive index distribution from the center of the particle through the shell and into the background material. The first-order theoretical predictions are confirmed by numerical simulations.
Cosmological Rotation of Quantum-Mechanical Origin and Anisotropy of the Microwave Background
Creators: name: Grishchuk, L. P.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It is shown that rotational cosmological perturbations can be generated in the early Universe, similarly to gravitational waves. The generating mechanism is quantum-mechanical in its nature, and the created perturbations should now be placed in squeezed vacuum quantum states. The physical conditions under which the phenomenon can occur are formulated. The generated perturbations can contribute to the large-angular-scale anisotropy of the cosmic microwave background radiation. An exact formula is derived for the angular correlation function of the temperature variations caused by the quantum-mechanically generated rotational perturbations. The multipole expansion begins from the dipole component. The comparison with the case of gravitational waves is made.
description: WUGRAV 93-6, Phys. Rev. D (in press), 33 pages
Software development for the use of a mathematical prediction tool for chemotherapy responsiveness in a clinical and in a research environment
Creators: name: Zink, Elisabeth
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Since cancer is the second most common cause of death in Ireland (Irish Cancer Society, 2013), there is great potential to improve personal treatment of cancer patients and to reduce the mortality rate. The search for biomarkers to predict the responsiveness to chemotherapy fails for certain cancer types due to their high heterogeneity. Integrating systems knowledge into biomarker research can improve the classification of patients into responder and non-responder. For instance the systems model APOPTO-CELL, which was developed in our group previously, predicts the treatment outcome of stage II and stage III colorectal cancer patients (Hector et al, 2012). This mathematical model outperforms classical statistical methods and is able to calculate whether targeted therapeutics such as apoptosis sensitizers may improve the responsiveness of individual patients to chemotherapy. Interviews with physicians and pathologists revealed that there is a need for prediction tools such as APOPTO-CELL that can support the consultant in the treatment decision process. APOPTO-CELLup could be validated successfully against the original published version. We therefore investigated how APOPTO-CELL may be integrated into a clinical diagnostic environment. For this purpose a requirement analysis was performed and as a result two possible use cases, one in the clinical pathology and the other in the clinical research setting were defined. Based on the use cases, a prototype for a graphical user interface was developed. Feedback from potential users resulted in a refined user interface that can be integrated into existing clinical workflows. APOPTO-CELL provides the prediction of treatment responsiveness in different standardized exchange formats. Here, I present a workflow integration strategy and a functional prototype for the APOPTO-CELL response prediction. A final application of the model to a patient set with 221 stage II and III CRC patients revealed that the model is able to predict chemotherapy responsiveness in patients with stage III CRC and classify correctly responders and non- responders to chemotherapy.
Additional file 2 of Complete plastome sequencing resolves taxonomic relationships among species of Calligonum L. (Polygonaceae) in China
Creators: name: Song, Feng
name: Li, Ting
name: Burgess, Kevin S.
name: Feng, Ying
name: Ge, Xue-Jun
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S1. Sequence identity plots for 21 assembled Calligonum chloroplast. Genomes, with C. jeminaicum as reference (left). Special insertion (or deletion) test results (right). Segments I: about 800 bp, segments II: about 400 bp.
Bernstein-Bezier Bases for Tetrahedral Finite Elements
Creators: name: Ainsworth, Mark
name: Fu, Guosheng
Publisher: name: arXiv
Year: 2018
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We present a new set of basis functions for H(curl)-conforming, H(div)-conforming, and L2 -conforming finite elements of arbitrary order on a tetrahedron. The basis functions are expressed in terms of Bernstein polynomials and augment the natural H1 -conforming Bernstein basis. The basis functions respect the differential operators, namely, the gradients of the high-order H1 -conforming Bernstein-Bezier basis functions form part of the H(curl)-conforming basis, and the curl of the high-order, non-gradients H(curl)-conforming basis functions form part of the H(div)-conforming basis, and the divergence of the high-order, non-curl H(div)-conforming basis functions form part of the L2-conforming basis. Procedures are given for the efficient computation of the mass and stiffness matrices with these basis functions without using quadrature rules for (piece-wise) constant coefficients on affine tetrahedra. Numerical results are presented to illustrate the use of the basis to approximate representative problems.
description: 27 pages
ORCID adoption in academic communities survey
Creators: name: Borger, Eva
name: Clements, Anna
Publisher: name: figshare
Year: 2018
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: The survey described in this document has been developed using the Qualtrics survey platform as part of an OCLC / ALISE funded study investigating the adoption of ORCID iDs in academic communities. It aims to reveal insights into participants’ adoption, understanding and usage of ORCID iDs.
Fuzzy almost quadratic functions
Creators: name: Mirmostafaee, A. K.
name: Moslehian, M. S.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46S40, 39B52, 39B82, 26E50

description: We approximate a fuzzy almost quadratic function by a quadratic function in a fuzzy sense. More precisely, we establish a fuzzy Hyers--Ulam--Rassias stability of the quadratic functional equation $f(x+y)+f(x-y)=2f(x)+2f(y)$. Our result can be regarded as a generalization of the stability phenomenon in the framework of normed spaces. We also prove a generalized version of fuzzy stability of the Pexiderized quadratic functional equation $f(x+y)+f(x-y)=2g(x)+2h(y)$.
description: 17 pages
Multiple stellar populations in Magellanic Cloud clusters. VI. A survey of multiple sequences and Be stars in young clusters
Creators: name: Milone, A. P.
name: Marino, A. F.
name: Di Criscienzo, M.
name: D'Antona, F.
name: Bedin, L. R.
name: Da Costa, G.
name: Piotto, G.
name: Tailo, M.
name: Dotter, A.
name: Angeloni, R.
name: Anderson, J.
name: Jerjen, H.
name: Li, C.
name: Dupree, A.
name: Granata, V.
name: Lagioia, E. P.
name: Mackey, A. D.
name: Nardiello, D.
name: Vesperini, E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The split main sequences (MSs) and extended MS turnoffs (eMSTOs) detected in a few young clusters have demonstrated that these stellar systems host multiple populations differing in a number of properties such as rotation and, possibly, age.We analyze Hubble Space Telescope photometry for thirteen clusters with ages between ~40 and ~1000 Myrs and of different masses. Our goal is to investigate for the first time the occurrence of multiple populations in a large sample of young clusters. We find that all the clusters exhibit the eMSTO phenomenon and that MS stars more massive than ~1.6 solar masses define a blue and red MS, with the latter hosting the majority of MS stars. The comparison between the observations and isochrones suggests that the blue MSs are made of slow-rotating stars, while the red MSs host stars with rotational velocities close to the breakup value. About half of the bright MS stars in the youngest clusters are H-alpha emitters. These Be stars populate the red MS and the reddest part of the eMSTO thus supporting the idea that the red MS is made of fast rotators. We conclude that the split MS and the eMSTO are a common feature of young clusters in both Magellanic Clouds. The phenomena of a split MS and an eMSTO occur for stars that are more massive than a specific threshold which is independent of the host-cluster mass. As a by-product, we report the serendipitous discovery of a young SMC cluster, GALFOR1.
description: 22 pages, 20 figures, accepted for publication in MNRAS
Complementary metal-oxide semiconductor compatible source of single photons at near-visible wavelengths
Creators: name: Cernansky, Robert
name: Martini, Francesco
name: Politi, Alberto
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate on chip generation of correlated pairs of photons in the near-visible spectrum using a CMOS compatible PECVD Silicon Nitride photonic device. Photons are generated via spontaneous four wave mixing enhanced by a ring resonator with high quality Q-factor of 320,000 resulting in a generation rate of 950,000 $\frac{pairs}{mW}$. The high brightness of this source offers the opportunity to expand photonic quantum technologies over a broad wavelength range and provides a path to develop fully integrated quantum chips working at room temperature.
description: 4 pages, 5 figures
Precession, nutation, and space geodetic determination of the Earth's variable gravity field
Creators: name: Bourda, G.
name: Capitaine, N.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Precession and nutation of the Earth depend on the Earth's dynamical flattening, H, which is closely related to the second degree zonal coefficient, J2 of the geopotential. A small secular decrease as well as seasonal variations of this coefficient have been detected by precise measurements of artificial satellites (Nerem et al. 1993; Cazenave et al. 1995) which have to be taken into account for modelling precession and nutation at a microarcsecond accuracy in order to be in agreement with the accuracy of current VLBI determinations of the Earth orientation parameters. However, the large uncertainties in the theoretical models for these J2 variations (for example a recent change in the observed secular trend) is one of the most important causes of why the accuracy of the precession-nutation models is limited (Williams 1994; Capitaine et al. 2003). We have investigated in this paper how the use of the variations of J2 observed by space geodetic techniques can influence the theoretical expressions for precession and nutation. We have used time series of J2 obtained by the "Groupe de Recherches en Géodésie spatiale" (GRGS) from the precise orbit determination of several artificial satellites from 1985 to 2002 to evaluate the effect of the corresponding constant, secular and periodic parts of H and we have discussed the best way of taking the observed variations into account. We have concluded that, although a realistic estimation of the J2 rate must rely not only on space geodetic observations over a limited period but also on other kinds of observations, the monitoring of periodic variations in J2 could be used for predicting the effects on the periodic part of the precession-nutation motion.
Eco-toxicity of water, soil, and sediment from agricultural areas of Kilombero Valley Ramsar wetlands, Tanzania
Creators: name: Materu, S. F.
name: Heise, S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: This study was conducted in the KVRS to; evaluate the seasonal eco-toxicity of water, soil and sediment samples; establish the suitability of using temperate biotest batteries in tropical systems; classify the toxicity of samples using Fuzzy Rules to estimate potential ecological risks. 143 water, sediment, and soil samples were collected during dry and rainy seasons in plantation areas. Pseudokirchneriella subcapitata, Aliivibrio fischeri and Arthrobacter globiformis bioassays were used to assess the toxicity of the samples. Results were categorized and classified into toxicity classes. Dry season presented a significantly higher mean inhibition of 31% than 5% shown by rainy season samples (p < 0.001) in the bacterial bioassays, indicating a lower concentration of contaminants due to flooding and increased surface runoff. A few sediment samples resulted into 100% inhibition of A. globiformis, implying organisms were physiologically inactive upon exposure to contaminants. Seventy-three percent of samples posed little or no toxic potential risk, 25% posed critical risk and 1% posed elevated critical risk, implying the KVRS ecosystem might be at risk if the extensive usage of pesticides in the area is not well managed and monitored. The temperate micro-biotests can be used in tropical systems, but with further research on suitable organisms and standardized methods.
Anomalies in the effective theory of heavy quarks
Creators: name: Soto, J.
name: Tzani, R.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The question of the anomalies in the effective theory of heavy quarks is investigated at two different levels. Firstly, it is shown that none of the symmetries of this effective theory contains an anomaly. The existence of a new `$ γ_ 5 $'-symmetry is pointed out and shown to be also anomaly free. Secondly, it is shown that the chiral anomaly of QCD is not reproduced in the effective lagrangian for the heavy quarks, thus contradicting 't Hooft's anomaly matching condition. Finally, the effective theory of heavy quarks is derived from the QCD lagrangian in such a way that the terms leading to the anomaly are included. For this derivation the generating functional method is used.
description: 16 pages, UB-ECM-PF-92/15
Characterising falls risk factors and health care utilisation in patients with a low trauma wrist fracture attending a physiotherapy clinic
Creators: name: O'Reilly, Ciara
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Introduction: Ireland's population is ageing and falls continue to be the most common cause of injury for those aged over 65. International guidelines recommend screening of low-risk falls patients in order to prevent significant impairments in the future. Mallmin et al (1993) stated that distal radius fractures occur on average 15 years prior to a hip fracture. Aims and Objectives: The aim of this study was to characterise multifactorial falls risk factors in subjects who had sustained a low trauma wrist fracture and identify their health care utilisation. Methods: This was a case-control, observational study which involved recruitment of 41 consecutive adults between 55 and 80 years who sustained a low trauma wrist fracture. For comparison 41 healthy controls were also recruited. A comprehensive multi-factorial falls assessment was performed on both groups. Results: The mean age of the female cases (n=36) was 68.19± 6.71 and the male cases (n=5) was 61.0± 6.75. There were statistically significant differences in the TUG test (p Conclusions and Implications: This study identified the presence of both intrinsic and extrinsic falls risk factors in subjects who sustained a low-trauma wrist fracture. Furthermore, 92% of the subjects required an intervention which they would not routinely have received, highlighting the increased health care needs of this cohort. The findings of this study could form the basis of the development of a targeted falls prevention screening tool and intervention programme for patients over 55 years of age patients who sustain a fragility fracture.
Visual clutter reduction in zoomable proportional point symbol maps
Creators: name: Opach, Tomasz
name: J. Korycka-Skorupa
name: I. Karsznia
name: T. Nowacki
name: I. Gołębiowska
name: J. K. Rød
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Proportional point symbols are commonly used in map displays. However, when such displays are zoomed out, the available map space shrinks and consequently symbols overlap and the display suffers from visual clutter. Therefore, solutions are needed to reduce visual clutter in zoomable map displays that contain proportional point symbols. The authors add to the body of knowledge through the investigation of the performance of three solutions: aggregation of unit areas, the displacement of overlapping symbols, and modified symbolization; four variations of modified symbolization are examined in detail. The original study begins with a consideration of the strengths and weaknesses of the solutions, with an emphasis on information loss. Thereafter, user sessions with 165 participants are arranged to gain empirical evidence of the performance of the solutions. The results reveal that although participants zoom out the map to zoom levels that implement visual clutter reduction techniques, they tend to zoom in the map and pan it to examine specific areas. Moreover, they willingly use the map with aggregated unit areas in cases when the solution facilitates task accomplishment. A certain amount of skepticism attaches to the solution that displaces overlapping symbols.
Revisiting $A_4$ model for leptons in light of NuFIT 3.2
Creators: name: Kang, Sin Kyu
name: Shimizu, Yusuke
name: Takagi, Kenta
name: Takahashi, Shunya
name: Tanimoto, Morimitsu
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We revisit the $A_4$ model for leptons in light of new result of NuFIT 3.2. We introduce a new flavon $η$ transforming as $A_4$ singlet $1'$ or $1"$ which couples to both charged leptons and neutrinos in next-leading order operators. The model consists of the five parameters: the lightest neutrino mass $m_1$, the vacuum expectation value of $η$ and three CP violating phases after inputting the experimental values of $Δm_{\rm atm}^2$ and $Δm_{\rm sol}^2$. The model with the $1"$ singlet flavon gives the prediction of $\sin^2 θ_{12}$ around the best fit of NuFIT 3.2 while keeping near the maximal mixing of $θ_{23}$. Inputting the experimental mixing angles with the $1\,σ$ error-bar, the Dirac CP violating phase is clearly predicted to be $|δ_\text{CP}|=50^\circ- 120^\circ$, which will be tested by the precise observed value in the future. In order to get the best fit value $\sin^2θ_{23}=0.538$, the sum of three neutrino masses is predicted to be larger than $90\,$meV. The cosmological observation for the sum of neutrino masses will also provide a crucial test of our predictions. It is remarked that the model is consistent with the experimental data only for the normal hierarchy of neutrino masses.
description: 21 pages, 14 figures
Adiabatic Invariants in Stellar Dynamics: I. Basic concepts
Creators: name: Weinberg, Martin D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The adiabatic criterion, widely used in astronomical dynamics, is based on the harmonic oscillator. It asserts that the change in action under a slowly varying perturbation is exponentially small. Recent mathematical results precisely define the conditions for invariance show that this model does not apply in general. In particular, a slowly varying perturbation may cause significant evolution stellar dynamical systems even if its time scale is longer than any internal orbital time scale. This additional `heating' may have serious implications for the evolution of star clusters and dwarf galaxies which are subject to long-term environmental forces. The mathematical developments leading to these results are reviewed, and the conditions for applicability to and further implications for stellar systems are discussed. Companion papers present a computational method for a general time-dependent disturbance and detailed example.
description: uuencoded compressed PostScript, Preprint 94-1
Seismic Rayleigh waves on an exponentially graded, orthotropic half-space
Creators: name: Destrade, Michel
Publisher: name: arXiv
Year: 2007
Subjects: subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Efforts at modelling the propagation of seismic waves in half-spaces with continuously varying properties have been mostly focused on shear-horizontal waves. Here a sagittaly polarized (Rayleigh type) wave travels along a symmetry axis (and is attenuated along another) of an orthotropic material with stiffnesses and mass density varying in the same exponential manner with depth. Contrary to what could be expected at first sight, the analysis is very similar to that of the homogeneous half-space, with the main and capital difference that the Rayleigh wave is now dispersive. The results are illustrated numerically for (i) an orthotropic half-space typical of horizontally layered and vertically fractured shales and (ii) for an isotropic half-space made of silica. In both examples, the wave travels at a slower speed and penetrates deeper than in the homogeneous case; in the second example, the inhomogeneity can force the wave amplitude to oscillate as well as decay with depth, in marked contrast with the homogeneous isotropic general case.
description: 8 pages
Canonical Quantization of Spherically Symmetric Gravity in Ashtekar's Self-Dual Representation
Creators: name: Thiemann, T.
name: Kastrup, H. A.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show that the quantization of spherically symmetric pure gravity can be carried out completely in the framework of Ashtekar's self-dual representation. Consistent operator orderings can be given for the constraint functionals yielding two kinds of solutions for the constraint equations, corresponding classically to globally nondegenerate or degenerate metrics. The physical state functionals can be determined by quadratures and the reduced Hamiltonian system possesses 2 degrees of freedom, one of them corresponding to the classical Schwarzschild mass squared and the canonically conjugate one representing a measure for the deviation of the nonstatic field configurations from the static Schwarzschild one. There is a natural choice for the scalar product making the 2 fundamental observables self-adjoint. Finally, a unitary transformation is performed in order to calculate the triad-representation of the physical state functionals and to provide for a solution of the appropriately regularized Wheeler-DeWitt equation.
description: 43 pages
A Mazur--Ulam theorem in non-Archimedean normed spaces
Creators: name: Moslehian, Mohammad Sal
name: Sadeghi, Ghadir
Publisher: name: arXiv
Year: 2007
Subjects: subject: Functional Analysis (math.FA)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 46S10, 47S10, 26E30, 12J25

description: The classical Mazur--Ulam theorem which states that every surjective isometry between real normed spaces is affine is not valid for non-Archimedean normed spaces. In this paper, we establish a Mazur--Ulam theorem in the non-Archimedean strictly convex normed spaces.
description: 5 pages, to appear in Nonlinear Analysis: Theory, Methods & Applications
From synchronous to one-time delayed dynamics in coupled maps
Creators: name: Anteneodo, Celia
name: Gonzalez-Avella, Juan Carlos
name: Vallejos, Raul O.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study the completely synchronized states (CSSs) of a system of coupled logistic maps as a function of three parameters: interaction strength ($\varepsilon$), range of the interaction ($α$), that can vary from first-neighbors to global coupling, and a parameter ($β$) that allows to scan continuously from non-delayed to one-time delayed dynamics. % We identify in the plane $α$-$\varepsilon$ periodic orbits, limit cycles and chaotic trajectories, and describe how these structures change with the delay. These features can be explained by studying the bifurcation diagrams of a two-dimensional non-delayed map. This allows us to understand the effects of one-time delays on CSSs, e.g, regularization of chaotic orbits and synchronization of short-range coupled maps, observed when the dynamics is moderately delayed. Finally, we substitute the logistic map by cubic and logarithmic maps, in order to test the robustness of our findings.
Microemulsion-based anthocyanin systems: effect of surfactants, cosurfactants, and its stability
Creators: name: Chen, Jian
name: Ma, Xin-hui
name: Yao, Guang-long
name: Zhang, Wen-ting
name: Zhao, Ying
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Anthocyanins exhibit natural antioxidants but exhibit poor stability and low oil solubility. Therefore, increasing the stability and fat solubility of anthocyanins is necessary to broaden their applications. In our experiment, an anthocyanin microemulsion system was constructed and its stability was investigated. At an oil phase and emulsifier ratio of 7:3, the hydrophilic oil-wet value reached 7.5 and the Km was 2:1. Furthermore, the microemulsion area was the largest. The bicontinuous region of the microemulsion exhibited optimal experimental conditions and resulted in a microemulsion containing 425.54 ± 1.58 μg/g anthocyanins. The anthocyanin microemulsion was a water-in-oil type, with a particle size of 0.07 ± 0.009 μm. Moreover, the temperature, light, and sample observation tests showed that the anthocyanin retention rate in the microemulsion was higher than that in the anthocyanin solution. Low-concentration NaCl and less than 9% of glucose and sucrose exerted no significant influence on the anthocyanin microemulsion stability.
The Development of an Assay to Evaluate the Efficacy of a Novel GPIb Antagonist, and the Functional Characterisation of the Drug
Creators: name: Cox, Alysia
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Thrombosis is central to the pathogenesis of many life-threatening diseases, including stroke and myocardial infarction. Current treatments for thrombosis, particularly anti-platelet agents that target GPIIb/IIIa, can cause serious bleeding complications. Unlike GPIIb/IIIa, GPIb initiates thrombus formation at the high shear stress that is prominent in atherosclerotic vessels. Therefore, this target could prevent pathological thrombosis while leaving normal haemostasis at low shear rates relatively unaffected. Anfibatide is a novel GPIb antagonist isolated from snake venom in China. Anfibatide will enter phase Ib-IIa trials in early 2015 and therefore, it is necessary to develop an assay to measure its efficacy in patients. We have developed a flow cytometry based receptor occupancy assay. In this assay, total GPIb receptor numbers are measured using an anti-GPIb monoclonal antibody, and the percentage of GPIb receptor occupancy by anfibatide is measured. Receptor occupancy by anfibatide correlated with dose-dependent inhibition of ristocetin-induced aggregation in whole blood by anfibatide. Functional studies were carried out using anfibatide. Anfibatide did not inhibit binding of two anti-GPIIb/IIIa antibodies. Anfibatide partially inhibited the anti-GPIb antibodies VM16d, and SZ 2, indicating that it binds to GPIbα between the thrombin-binding site and the sulfated tyrosine motif. Anfibatide did not cause platelet activation or loss of single platelets in vitro. Anfibatide had no effect on aggregation induced by low dose or high dose thrombin, ADP or arachidonic acid. Anfibatide inhibited Streptococcus sanguinis 133-79 induced aggregation by 50% in half of healthy donors, but had no effect on Staphylococcus aureus Newman aggregation. The receptor occupancy assay is optimised and available for use in Phase Ib-IIa clinical trials, and in future clinical use of anfibatide.
Non-Gaussian Corrections to Higgs Mass in Autonomous lambda phi**4
Creators: name: Ritschel, Uwe
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recent calculations in one-loop and Gaussian appro- ximation, using the so-called autonomous renormalization scheme, indicate a comparatively massive, narrow Higgs excitation at about 2 TeV. Here I show that this result qualitatively persists in the framework of a post-Gaussian variational approximation for the pure O(N)-symmetric phi**4-theory for N>1. The method is based on nonlinear transformations of path-integral variables, and the optimization amounts to a Schwinger-Dyson-type summation of diagrams. In the case of O(4), for example, I find M_Higgs = 2.3 TeV, compared to 1.9 TeV and 2.1 TeV in 1-loop and Gaussian approximation, respectively.
description: 12 pages
Adiabatic Invariants in Stellar Dynamics: II. Gravitational shocking
Creators: name: Weinberg, Martin D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A new theory of gravitational shocking based on time-dependent perturbation theory shows that the changes in energy and angular momentum due to a slowly varying disturbance are not exponentially small for stellar dynamical systems in general. It predicts significant shock heating by slowly varying perturbations previously thought to be negligible according to the adiabatic criterion. The theory extends the scenarios traditionally computed only with the impulse approximation and is applicable to a wide class of disturbances. The approach is applied specifically to the problem of disk shocking of star clusters.
description: uuencoded compressed PostScript, Preprint 94-2
title: Rethinking the Witness: Art After the Lebanese Wars
Creators: name: Saadawi, Ghalya
Publisher: name: Goldsmiths, University of London
Year: 2019

description: This thesis offers a critical investigation of art after the declared end of the Lebanese civil wars and their prolongation through various discourses and politics. This violence, insidious and structural, was said to have foreclosed certain forms of representation and of speech. The subsequent hijacking of time and space would demanded a rethinking of the witness, of representation, and of the politics of form in art. This rethinking asks what particular tactics in art, attentive to form and apparatus as much as to content, can oppose the ideologies in war and post-war discourse, but can produce and become the conditions of possibility for a politics of art. The declared end of the Lebanese wars coincided with the end of the Cold War and its concomitant muffling of a long history of revolution and counter-revolution, naturally also in the Lebanese post-civil war context. The thesis addresses how certain nascent artistic propositions challenged the crises of historical representation, legacies of witnessing, as well as the heart of testimony as fiction. It argues that certain Lebanese artists in the post-civil war era were attentive to form and to world in such as a way as to extend from waves of political modernism. Through tactics such as parody, direct modes of address, alienation effect, use of text and vernacular modes, to name but a few, they foregrounded an awareness of the ideologies of their apparatus, and brought forth a rethinking of witnessing as a political and historical position from which to speak.
Non-equilibrium turbulence scalings and self-similarity in turbulent planar jets
Creators: name: Cafiero, G
name: Vassilicos, JC
Publisher: name: arXiv
Year: 2018
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We study the self-similarity and dissipation scalings of a turbulent planar jet and the theoretically implied mean flow scalings. Unlike turbulent wakes where such studies have already been carried out (Dairay et al. 2015; Obligado et al. 2016), this is a boundary- free turbulent shear flow where the local Reynolds number increases with distance from inlet. The Townsend-George theory revised by Dairay et al. (2015) is applied to turbulent planar jets. Only a few profiles need to be self-similar in this theory. The self- similarity of mean flow, turbulence dissipation, turbulent kinetic energy and Reynolds stress profiles is supported by our experimental results from 18 to at least 54 nozzle sizes, the furthermost location investigated in this work. Furthermore, the non-equilibrium dissipation scaling found in turbulent wakes, decaying grid-generated turbulence, various instances of periodic turbulence and turbulent boundary layers (Vassilicos 2015, Dairay et al. 2015, Goto & Vassilicos 2015, Nedic et al. 2017) is also observed in the present turbulent planar jet and in the turbulent planar jet of Antonia et al. (1980). Given these observations, the theory implies new mean flow and jet width scalings which are found to be consistent with our data and the data of Antonia et al. (1980). In particular, it implies a hitherto unknown entrainment behaviour: the ratio of characteristic cross-stream to centreline streamwise mean flow velocities decays as the -1/3 power of streamwise distance in the region where the non-equilibrium dissipation scaling holds.
description: 26 pages
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0003v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0003v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0003v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v