cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Healing the Past by Nurturing the Future-co-designing perinatal strategies for Aboriginal and Torres Strait Islander parents experiencing complex trauma: framework and protocol for a community-based participatory action research study
Creators: name: Chamberlain, Catherine
name: Gee, Graham
name: Brown, Stephanie Janne
name: Atkinson, Judith
name: Herrman, Helen
name: Gartland, Deirdre
name: Glover, Karen
name: Clark, Yvonne
name: Campbell, Sandra
name: Mensah, Fiona K
name: Atkinson, Caroline
name: Brennan, Sue E
name: McLachlan, Helen
name: Hirvonen, Tanja
name: Dyall, Danielle
name: Ralph, Naomi
name: Hokke, Stacey
name: Nicholson, Jan
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Introduction Child maltreatment and other traumatic events can have serious long-term physical, social and emotional effects, including a cluster of distress symptoms recognised as 'complex trauma'. Aboriginal and Torres Strait Islander (Aboriginal) people are also affected by legacies of historical trauma and loss. Trauma responses may be triggered during the transition to parenting in the perinatal period. Conversely, becoming a parent offers a unique life-course opportunity for healing and prevention of intergenerational transmission of trauma. This paper outlines a conceptual framework and protocol for an Aboriginal-led, community-based participatory action research (action research) project which aims to co-design safe, acceptable and feasible perinatal awareness, recognition, assessment and support strategies for Aboriginal parents experiencing complex trauma. Methods and analysis This formative research project is being conducted in three Australian jurisdictions (Northern Territory, South Australia and Victoria) with key stakeholders from all national jurisdictions. Four action research cycles incorporate mixed methods research activities including evidence reviews, parent and service provider discussion groups, development and psychometric evaluation of a recognition and assessment process and drafting proposals for pilot, implementation and evaluation. Reflection and planning stages of four action research cycles will be undertaken in four key stakeholder workshops aligned with the first four Intervention Mapping steps to prepare programme plans. Ethics and dissemination Ethics and dissemination protocols are consistent with the National Health and Medical Research Council Indigenous Research Excellence criteria of engagement, benefit, transferability and capacity-building. A conceptual framework has been developed to promote the application of core values of safety, trustworthiness, empowerment, collaboration, culture, holism, compassion and reciprocity. These include related principles and accompanying reflective questions to guide research decisions.
The 'Pecked Stone', Trelleck, Monmouthshire: the siting of a former standing stone
Creators: name: J Powell, Martin
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 63-69
description: The precise location of the former standing stone known as the 'Pecked Stone', Monmouthshire, has long been a mystery. Two nineteenth-century antiquarian descriptions and local folklore suggest that the stone destroyed in the early nineteenth century was sited close to the Five Trees, north of the village of Trelleck and may originally have been associated with a barrow or cairn.
Pre-Iron Age domestic buildings in Wales
Creators: name: Burrow, Steve
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 71-103
description: The study of Wales' architecture is a well-developed field, but its narratives normally begin with the Iron Age, missing out the dwelling places of people over the preceding 9,000 years since the end of the Ice Age. This paper reviews the available evidence for domestic structures in Wales over this period scant in the Mesolithic, but with an increasing number of buildings known from the Neolithic and Bronze Age. Key themes illustrated by these buildings are discussed in the text, and a gazetteer provides a summary of the architectural form and chronological evidence for each one.
Additional file 3 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 3: CpG sites identified based on LMM or linear regression models testing associations between maternal AUCglu and DNAm in cord blood and/or in blood at 5 years of age; Table presenting CpG sites, including their chromosome number, genomic position, associated gene and regression beta and p-value, identified at suggestive P < 10−5 based on LMM or linear regression models testing association between maternal AUCglu and DNAm in cord blood and/or in blood at 5 years of age.
Additional file 4 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 4: Epigenome-wide association plot for maternal fasting glucose levels; Figure of the epigenome-wide association plot presenting CpG sites from the LMM associated with maternal fasting glucose.
Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands
Creators: name: Sikkema, Reina S.
name: Tobias, Tijs
name: Oreshkova, Nadia
name: de Bruin, Erwin
name: Okba, Nisreen
name: Chandler, Felicity
name: Hulst, Marcel M.
name: Rodon, Jordi
name: Houben, Manon
name: van Maanen, Kees
name: Bultman, Hans
name: Meester, Marina
name: Gerhards, Nora M.
name: Bouwknegt, Martijn
name: Urlings, Bert
name: Haagmans, Bart
name: Kluytmans, Jan
name: Kessel, Corine H. Geurtsvan
name: van der Poel, Wim H.M.
name: Koopmans, Marion P.G.
name: Stegeman, Arjan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands
Genetic polymorphism of angiotensin converting enzyme and angiotensin II type 1 receptors and their impact on the outcome of acute coronary syndrome
Creators: name: Fadhaa A Ghafil
name: Mohammad, Bassim I
name: Al-Janabi, Hussain S
name: Hadi, Najah R
name: Al-Aubaidy, Hayder
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 Elsevier Inc. This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril. Two hundred and fifty participants with ACS were included in this study (Group 1 (120) participants on captopril 25 mg twice daily and Group 2 (130) participants received no captopril (control study)). Participants were genotyped for ACE (rs4343) and AT1R (rs5182) polymorphisms and the phenotype was determined. ACE polymorphism (rs 4343) GG and GA genotypes are more related to STEMI (OR = 1.7, 1.5 respectively) and NSTEMI (OR = 3, 3.8 respectively), and they were more prone to have Percutaneous Coronary Intervention after ACS attack (OR = 11.6, 14.1 respectively). AT1R (rs 5182) CT genotype is mildly associated with STEMI (OR = 1.1), but also prone to have PCI after ACS attack (OR = 1.6) while TT genotype has a risk to get less improvement (OR = 1.8).
Supplementary_Table_1_1 – Supplemental material for ERCC1 expression and platinum chemosensitivity in patients with ovarian cancer: A meta-analysis
Creators: name: Zhang, Chunjie
name: Gao, Shan
name: Hou, Jingwen
Publisher: name: SAGE Journals
Year: 2020
Subjects: Oncology and Carcinogenesis not elsewhere classified

description: Supplemental material, Supplementary_Table_1_1 for ERCC1 expression and platinum chemosensitivity in patients with ovarian cancer: A meta-analysis by Chunjie Zhang, Shan Gao and Jingwen Hou in The International Journal of Biological Markers
Florence Nightingale's shells. Finding historical treasure among the collection of mollusc specimens in the University of Nottingham's Zoology Collection.
Creators: name: Hartman, Tom
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Florence Nightingale's shells. Finding historical treasure among the collection of mollusc specimens in the University of Nottingham's Zoology Collection. by Programme Chair Tom Hartman of Programme Chair University Of Nottingham Nottingham United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Castell Carndochan: survey and excavation 2014-17
Creators: name: Hopewell, David
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 177-207
description: The large apsidal tower at the small, ruinous Castell Carndochan is a diagnostic feature of thirteenth-century castles of the princes of Gwynedd. There are, however, no contemporary records of this castle. Survey and trial excavation undertaken between 2014 and 2017 suggest that in its first phase the castle comprised a small, central square tower enclosed by a defensive wall. The castle was subsequently remodelled by the insertion of an apsidal tower, a small D-shaped tower and a round tower into the curtain wall. The castle does not appear to have been intensively occupied and dating evidence is limited. The castle's setting, the continuity of building techniques and radiocarbon dates suggest that both phases of the castle belong to the reign of Llywelyn ab Iorwerth.
Local aspects of avian non-REM and REM sleep
Creators: name: Rattenborg, Niels C
name: van der Meij, Jacqueline
name: Beckers, Gabriël JL
name: Lesku, John
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3208
subject: Medical physiology
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 5202
subject: Biological psychology

description: Birds exhibit two types of sleep that are in many respects similar to mammalian rapid eye movement (REM) and non-REM (NREM) sleep. As in mammals, several aspects of avian sleep can occur in a local manner within the brain. Electrophysiological evidence of NREM sleep occurring more deeply in one hemisphere, or only in one hemisphere-the latter being a phenomenon most pronounced in dolphins-was actually first described in birds. Such asymmetric or unihemispheric NREM sleep occurs with one eye open, enabling birds to visually monitor their environment for predators. Frigatebirds primarily engage in this form of sleep in flight, perhaps to avoid collisions with other birds. In addition to interhemispheric differences in NREM sleep intensity, the intensity of NREM sleep is homeostatically regulated in a local, use-depended manner within each hemisphere. Furthermore, the intensity and temporo-spatial distribution of NREM sleep-related slow waves varies across layers of the avian hyperpallium- A primary visual area-with the slow waves occurring first in, and propagating through and outward from, thalamic input layers. Slow waves also have the greatest amplitude in these layers. Although most research has focused on NREM sleep, there are also local aspects to avian REM sleep. REM sleep-related reductions in skeletal muscle tone appear largely restricted to muscles involved in maintaining head posture. Other local aspects of sleep manifest as a mixture of features of NREM and REM sleep occurring simultaneously in different parts of the neuroaxis. Like monotreme mammals, ostriches often exhibit brainstem-mediated features of REM sleep (muscle atonia and REMs) while the hyperpallium shows EEG slow waves typical of NREM sleep. Finally, although mice show slow waves in thalamic input layers of primary sensory cortices during REM sleep, this is not the case in the hyperpallium of pigeons, suggesting that this phenomenon is not a universal feature of REM sleep. Collectively, the local aspects of sleep described in birds and mammals reveal that wakefulness, NREM sleep, and REM sleep are not always discrete states.
Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
Creators: name: Fernández-Pato, Asier
name: Virseda-Berdices, Ana
name: Resino, Salvador
name: Ryan, Pablo
name: Martínez-González, Oscar
name: Pérez-García, Felipe
name: Martin-Vicente, María
name: Valle-Millares, Daniel
name: Brochado-Kith, Oscar
name: Blancas, Rafael
name: Martínez, Amalia
name: Ceballos, Francisco C.
name: Bartolome-Sánchez, Sofía
name: Vidal-Alcántara, Erick Joan
name: Alonso, David
name: Blanca-López, Natalia
name: Martinez-Acitores, Ignacio Ramirez
name: Martin-Pedraza, Laura
name: Jiménez-Sousa, María Ángeles
name: Fernández-Rodríguez, Amanda
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were also assessed. COVID-19 patients showed 200 significant differentially expressed (SDE) miRNAs concerning healthy controls, with upregulated putative targets of SARS-CoV-2, and inflammatory miRNAs. Among COVID-19 patients, 75 SDE miRNAs were observed in asymptomatic/mild compared to symptomatic patients, which were involved in platelet aggregation and cytokine pathways, among others. Moreover, 137 SDE miRNAs were identified between severe and moderate patients, where miRNAs targeting the SARS CoV-2 genome were the most strongly disrupted. Finally, we constructed a mortality predictive risk score (miRNA-MRS) with ten miRNAs. Patients with higher values had a higher risk of 90-days mortality (hazard ratio = 4.60; p-value < 0.001). Besides, the discriminant power of miRNA-MRS was significantly higher than the observed for age and gender (AUROC = 0.970 vs. 0.881; p = 0.042). SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality.
Additional file 8 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 8: CpG sites identified in linear mixed models testing associations between maternal 1h-glucose post-OGTT and DNAm measured in cord blood and blood at 5 years of age; Table presenting CpG sites, including their chromosome number, genomic position, and associated gene, identified at suggestive P < 10−5 in linear mixed models testing associations between maternal 1h post-OGTT glucose levels and DNAm measured in cord blood and blood at 5 years of age.
sj-pdf-1-jou-10.1177_1464884920969092 – Supplemental material for Let’s dance the news! How the news media are adapting to the logic of TikTok
Creators: name: Vázquez-Herrero, Jorge
name: Negreira-Rey, María-Cruz
name: López-García, Xosé
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, sj-pdf-1-jou-10.1177_1464884920969092 for Let’s dance the news! How the news media are adapting to the logic of TikTok by Jorge Vázquez-Herrero, María-Cruz Negreira-Rey and Xosé López-García in Journalism
sj-pdf-1-fty-10.1177_1464700120967311 - Supplemental material for Feminist matters, critique and the future of the political
Creators: name: Bargetz, Brigitte
name: Sanos, Sandrine
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Gender studies
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-fty-10.1177_1464700120967311 for Feminist matters, critique and the future of the political by Brigitte Bargetz and Sandrine Sanos in Feminist Theory
PupilDilationStudy_ResponseAppendixRedacted – Supplemental material for Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation
Creators: name: Szpernal, Jacob
name: Carroll, Joseph
name: Spellecy, Ryan
name: Groth, Jane A. Bachman
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, PupilDilationStudy_ResponseAppendixRedacted for Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation by Jacob Szpernal, Joseph Carroll, Ryan Spellecy and Jane A. Bachman Groth in Journal of Empirical Research on Human Research Ethics
In the land of Beulah: the Roman military complex at Caerau, Breconshire
Creators: name: Hankinson, Richard
name: J Britnell, William
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 105-125
description: Assessment work was carried out on the complex of Roman military sites near Caerau, Breconshire by the Clwyd-Powys Archaeological Trust between 1990 and 2015 primarily for management and conservation purposes, involving topographical survey, geophysical survey, drone photogrammetry, analysis of lidar imagery, test pit digging and trial excavation. Sites examined included the Caerau Roman fort and its associated annexe and extramural settlement, Beulah marching camp, and practice camps, largely dating to the period c. AD 75-120.
Roman settlement and industry along the Dee Estuary: recent discoveries at Pentre Ffwrndan, Flintshire
Creators: name: W Jones, Nigel
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 127-163
description: The article presents an assessment of Roman activity along the Dee Estuary coastal strip in Flintshire, together with reports on recent excavations north-west of Chester Road, Pentre Ffwrndan. A Roman settlement related to the lead industry has been known in this area since the nineteenth century, with the discovery of a number of furnaces, from which the modern settlement takes its name. Excavations in the 1920s and 1930s uncovered the partial plan of several buildings, as well as further evidence for lead working, although it was not until the mid 1970s that any comprehensive investigation was conducted, with the excavation of a Roman official building at Pentre Farm. Recent developer-funded excavations have revealed significant new information, some of which has not been published previously, confirming the presence of a ribbon settlement along the Roman road from Chester to Caernarfon, as well as a cremation cemetery.
Prydd y Moch, Ellesmere, and Llywelyn ab Iorwerth's Shropshire campaigns
Creators: name: Owen Jones, Craig
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 165-176
description: Beyond the accounts contained in Welsh chronicles, little is known of the early military campaigns of Llywelyn ab Iorwerth. Two references in the poetry of Llywarch ap Llywelyn, otherwise known as Prydydd y Moch (fl. 1173-c. 1220), to an attack by Llywelyn ab Iorwerth on Ellesmere are therefore worthy of further scrutiny, as history records no such attack. Close examination of the history of the manor of Ellesmere as well as the diplomacy of Llywelyn and King John enable us to suggest two occasions on which such an attack was politically feasible, namely Llywelyn's campaign of mid-1212, and his campaign during the spring of 1215 that culminated in the capture of Shrewsbury. Based on internal evidence supported by references in English administrative documents, it is postulated that both poems were written after mid-1212, and that the awdl known as the Canu Mawr may have been composed as late as 1215.
The effects of microcrystalline cellulose on the flammability and thermal behaviours of flame retarded natural fibre epoxy composite
Creators: name: Pooria Khalili
name: Liu, Xiao Ling
name: Tshai, Kim Yeow
name: Kong, Ing
name: Rudd, Chris
name: Yi, Xiao Su
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019, Emerald Publishing Limited. Purpose: The purpose of this paper is to fabricate and characterize the natural fibre (NF) reinforced epoxy composites containing flame retardants (FRs) and microcrystalline cellulose (MCC) in terms of flammability, thermal properties and dynamic mechanical performances. Design/methodology/approach: The FRs used in this study were ammonium polyphosphate and alumina trihydrate. Findings: The results demonstrated that the addition of MCC particles into the flame retardant composite (control) further enhanced the self-extinguishing properties of composites, in particular, the burn length. Thermogravimetric analysis showed that the mass residue improved with every addition of MCC particles at 700 °C. For instance, the residual weight enhanced from 28.4 Wt.% to 33 Wt.% for the control and the composite with 7 Wt.% MCCs, respectively. As obtained from the dynamic mechanical analysis, the glass transition temperature of composites increased upon increasing inclusion of MCC particles. For example, this parameter was 77.1 °C and 86.8 °C for the control and composite loaded with 7 Wt.% MCC, respectively. Originality/value: Thus, the combination of MCC and FR had been proved to be a promising flame retardant system for NF reinforced epoxy.
Focusing on Users and Maximising Opportunities: the Sedgwick Museum Collections Research Centre, University of Cambridge
Creators: name: Hide, Liz
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Focusing on Users and Maximising Opportunities: the Sedgwick Museum Collections Research Centre, University of Cambridge by Director Liz Hide of Director Sedgwick Museum, University of Cambridge Cambridge United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Additional file 1 of Evaluation of muco-adhesive tacrolimus patch on caspase-3 induced apoptosis in oral lichen planus: a randomized clinical trial
Creators: name: Ibrahim, Suzan S.
name: Ragy, Nivine I.
name: Nagy, Noha A.
name: El-kammar, Hala
name: Elbakry, Asmaa M.
name: Ezzatt, Ola M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Manufacturer’s characterization of tacrolimus patch.
Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
Creators: name: Fernández-Pato, Asier
name: Virseda-Berdices, Ana
name: Resino, Salvador
name: Ryan, Pablo
name: Martínez-González, Oscar
name: Peréz-García, Felipe
name: Martin-Vicente, María
name: Valle-Millares, Daniel
name: Brochado-Kith, Oscar
name: Blancas, Rafael
name: Martínez, Amalia
name: Ceballos, Francisco C.
name: Bartolome-Sánchez, Sofía
name: Vidal-Alcántara, Erick Joan
name: Alonso, David
name: Blanca-López, Natalia
name: Martinez-Acitores, Ignacio Ramirez
name: Martin-Pedraza, Laura
name: Jiménez-Sousa, María Ángeles
name: Fernández-Rodríguez, Amanda
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were also assessed. COVID-19 patients showed 200 significant differentially expressed (SDE) miRNAs concerning healthy controls, with upregulated putative targets of SARS-CoV-2, and inflammatory miRNAs. Among COVID-19 patients, 75 SDE miRNAs were observed in asymptomatic/mild compared to symptomatic patients, which were involved in platelet aggregation and cytokine pathways, among others. Moreover, 137 SDE miRNAs were identified between severe and moderate patients, where miRNAs targeting the SARS CoV-2 genome were the most strongly disrupted. Finally, we constructed a mortality predictive risk score (miRNA-MRS) with ten miRNAs. Patients with higher values had a higher risk of 90-days mortality (hazard ratio=4.60; p-value<0.001). Besides, the discriminant power of miRNA-MRS was significantly higher than the observed for age and gender (AUROC=0.970 vs. 0.881; p=0.042). SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality.
Metformin attenuated sepsis-related liver injury by modulating gut microbiota
Creators: name: Liang, Huoyan
name: Song, Heng
name: Zhang, Xiaojuan
name: Song, Gaofei
name: Wang, Yuze
name: Ding, Xianfei
name: Duan, Xiaoguang
name: Li, Lifeng
name: Sun, Tongwen
name: Kan, Quancheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Increased evidence shows that gut microbiota acts as the primary regulator of the liver; however, their role in sepsis-related liver injury (SLI) in the elderly is unclear. This study assessed whether metformin could attenuate SLI by modulating gut microbiota in septic aged rats. Cecal ligation and puncture (CLP) was used to induce SLI in aged rats. Fecal microbiota transplantation (FMT) was used to validate the roles of gut microbiota in these pathologies. The composition of gut microbiota was analyzed by 16S rRNA sequencing. Moreover, the liver and colon tissues were analyzed by histopathology, immunofluorescence, immunohistochemistry,and reverse transcription polymerase chain reaction (RT-PCR). Metformin improved liver damage, colon barrier dysfunction in aged SLI rats. Moreover, metformin improved sepsis-induced liver inflammation and damage under the presence of gut microbiota. Importantly, FMT assay showed that rats gavaged with feces from metformin-treated SLI rats displayed fewer-severe liver damage and colon barrier dysfunction than did rats gavaged with feces from SLI rats.The gut microbiota composition among the sham-operated, CLP-operated and metformin-treated SLI rats were different. In particular, the proportion of Klebsiella and Escherichia_Shigella was higher in SLI rats than sham-operated and metformin-treated SLI rats;while metformin could increased the proportion of Bifidobacterium, Muribaculaceae, Parabacteroides_distasonis and Alloprevitella in aged SLI rats. Additionally, Klebsiella and Escherichia_Shigella correlated positively with the inflammatory factors in the liver. Our findings suggest that metformin may improve the liver injury by regulating the gut microbiota and alleviating colon barrier dysfunction in septic aged rats, which may be an effective therapy for SLI.
Ruthin Castle: illustrating the past
Creators: name: Davies, Will
name: Jones-Jenkins, Chris
name: Rees, Sian
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 213-223
description: A new reconstruction drawing is presented, suggesting how Ruthin Castle may have appeared towards the end of the medieval period. The reconstruction, commissioned by the Ruthin Castle Conservation Trust and part-funded by the Cambrian Archaeological Association in 2018, draws upon antiquarian descriptions and illustrations of the castle and on survey work commissioned by Cadw.
Elevated CO2 alters the structure of the bacterial community assimilating plant‐derived carbon in the rhizosphere of soya bean
Creators: name: Wang, Yan
name: ZH Yu
name: YS Li
name: GH Wang
name: Caixian Tang
name: XB Liu
name: Junjie Liu
name: ZH Xie
name: Jin, Jian
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 British Society of Soil Science Elevated CO2 (eCO2) increases rhizodeposits, which in turn alters the soil microbial community. However, it is not really known how the microbial community metabolizes plant-derived carbon (C) in the rhizosphere under eCO2, especially in agricultural soils. This study used a 13CO2 labelling technique combined with DNA-stable isotope probing (SIP) to fractionate the 13C-DNA and 12C-DNA from the rhizosphere of soya bean plants (Glycine max (L.) Merr. cv. Suinong 14) grown for 54 days under ambient CO2 (aCO2) (390 ppm) or eCO2 (550 ppm). The DNA fractions were then subjected to Illumina Miseq sequencing. The results showed that eCO2 decreased the richness and diversity of the 13C-assimilating bacterial community compared to aCO2 (p < 0.05). Elevated CO2 decreased the abundances of genera, including Pseudarthrobacter, Gaiellales_uncultured, Microlunatus, Gemmatimonas, Gemmatimonadaceae_uncultured, Ramlibacter, Massilia, Luteimonas, Acidobacteriaceae_uncultured, Bryobacter and Candidatus_Solibacter. These genera were probably fast-growing bacteria and sensitive to labile C. In contrast, eCO2 stimulated the growth of genera Novosphingobium, Acidimicrobiales_uncultured, Bacillus, Flavisolibacter and Schlesneria, which were able to assimilate complex C compounds. Moreover, the increased population of Novosphingobium under eCO2 might have accelerated electron flow from the oxidation of organic C. Correspondingly, eCO2 did not affect the concentration of the dissolved organic C but increased the plant-derived 13C in the rhizosphere. These results indicated that an eCO2-induced increase in non-labile C in rhizodeposits contributed to the increase in population size of a number of the plant-C-metabolizing genera that might become the mechanism for the turnover of fresh C in the rhizosphere, modifying the soil C cycle under eCO2 environments.
Additional file 2 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 2: Differentially methylated regions based on results from LMM testing associations between maternal AUCglu and DNAm measured in cord blood and blood at 5 years of age, using the DMRff method; Table presenting the differentially methylated regions, including their chromosome number, genomic position, number of CpGin the region, estimate value, standard error, P-value and adjusted P-value, based on results from LMM testing the association between maternal AUCglu and DNAm measured in cord blood at 5 years of age.
Cell membrane-anchored anti-HIV single-chain antibodies and bifunctional inhibitors targeting the gp41 fusion protein: new strategies for HIV gene therapy
Creators: name: Chen, Yue
name: Jin, Hongliang
name: Tang, Xiaoran
name: Li, Li
name: Geng, Xiuzhu
name: Zhu, Yuanmei
name: Chong, Huihui
name: He, Yuxian
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Emerging studies indicate that infusion of HIV-resistant cells could be an effective strategy to achieve a sterilizing or functional cure. We recently reported that glycosylphosphatidylinositol (GPI)-anchored nanobody or a fusion inhibitory peptide can render modified cells resistant to HIV-1 infection. In this study, we comprehensively characterized a panel of newly isolated HIV-1-neutralizing antibodies as GPI-anchored inhibitors. Fusion genes encoding the single-chain variable fragment (scFv) of 3BNC117, N6, PGT126, PGT128, 10E8, or 35O22 were constructed with a self-inactivating lentiviral vector, and they were efficiently expressed in the lipid raft sites of target cell membrane without affecting the expression of HIV-1 receptors (CD4, CCR5 and CXCR4). Significantly, transduced cells exhibited various degrees of resistance to cell-free HIV-1 infection and cell-associated HIV-1 transmission, as well as viral Env-mediated cell-cell fusion, with the cells modified by GPI-10E8 showing the most potent and broad anti-HIV activity. In mechanism, GPI-10E8 also interfered with the processing of viral Env in transduced cells and attenuated the infectivity of progeny viruses. By genetically linking 10E8 with a fusion inhibitor peptide, we subsequently designed a group of eight bifunctional constructs as cell membrane-based inhibitors, designated CMI01∼CMI08, which rendered cells completely resistant to HIV-1, HIV-2, and simian immunodeficiency virus (SIV). In human CD4+ T cells, GPI-10E8 and its bifunctional derivatives blocked both CCR5- and CXCR4-tropic HIV-1 isolates efficiently, and the modified cells displayed robust survival selection under HIV-1 infection. Therefore, our studies provide new strategies for generating HIV-resistant cells, which can be used alone or with other gene therapy approaches.
A cancelable iris-and steganography-based user authentication system for the internet of things
Creators: name: Yang, Wencheng
name: Wang, Song
name: Hu, J
name: Ibrahim, A
name: Zheng, G
name: Macedo, MJ
name: Johnstone, MN
name: Valli, C
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Remote user authentication for Internet of Things (IoT) devices is critical to IoT security, as it helps prevent unauthorized access to IoT networks. Biometrics is an appealing authentication technique due to its advantages over traditional password-based authentication. However, the protection of biometric data itself is also important, as original biometric data cannot be replaced or reissued if compromised. In this paper, we propose a cancelable iris-and steganography-based user authentication system to provide user authentication and secure the original iris data. Most of the existing cancelable iris biometric systems need a user-specific key to guide feature transformation, e.g., permutation or random projection, which is also known as key-dependent transformation. One issue associated with key-dependent transformations is that if the user-specific key is compromised, some useful information can be leaked and exploited by adversaries to restore the original iris feature data. To mitigate this risk, the proposed scheme enhances system security by integrating an effective information-hiding technique—steganography. By concealing the user-specific key, the threat of key exposure-related attacks, e.g., attacks via record multiplicity, can be defused, thus heightening the overall system security and complementing the protection offered by cancelable biometric techniques.
The persistence of rood lofts in Welsh churches
Creators: name: Pipes, Rose
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 225-256
description: Compared with England, Wales is relatively well-endowed with churches in which substantial elements of their original rood lofts remain in place. Wales is also fortunate in that its churches attracted the interest of a handful of nineteenth- and early twentieth-century antiquarians and travellers who, among them, visited virtually every church in the country and recorded what they found. It is largely from their accounts that the gazetteer and map which accompany the article have been compiled. The article looks at the original purposes for which rood lofts were constructed then examines the main sources of attack upon them, from the Reformation to the near present. The final sections consider possible reasons for the persistence of rood lofts in Wales. Is it a story of defiance, indifference, remoteness from scrutiny, the power of local patrons, poverty, pride, inertia, or a mixture of some or all of these?
Fragmented DNA in formalin-preserved specimens and where to find it
Creators: name: Hahn, Erin
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Fragmented DNA in formalin-preserved specimens and where to find it by Postdoctoral Fellow Erin Hahn of Postdoctoral Fellow CSIRO Canberra Australia for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Additional file 5 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 5: Epigenome-wide association plot for maternal 1h-post-OGTT glucose levels; Figure of epigenome-wide association plot presenting CpG sites from the LMM associated with maternal 1h-post-OGTT glucose levels.
Short screening tools for risky drinking in Aboriginal and Torres Strait Islander Australians: modified AUDIT-C and a new approach
Creators: name: Lee, Kylie
name: Conigrave, James
name: Wilson, Scott
name: Perry, Christopher
name: Callinan, Sarah
name: Room, Robin
name: Chikritzhs, Tanya N
name: Slade, Tim
name: Hayman, Noel
name: Leggat, Geoffrey
name: Conigrave, Katherine M
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health
classificationCode: 5203
subject: Clinical and health psychology

description: BACKGROUND: Alcohol consumption among Indigenous Australians can involve a stop-start pattern of drinking, with consumption well above recommended guidelines on each occasion. Such intermittent drinking patterns can make screening for risky drinking difficult. This study evaluates the ability of several short alcohol screening tools, contained in the Grog Survey Application, to detect short- or long-term risky drinking as defined by Australian guidelines. Tested tools include a modification of Alcohol Use Disorders Identification Test-Consumption (AUDIT-Cm). METHODS: Alcohol consumption was assessed in current drinkers in the past year (n = 184) using AUDIT-Cm and using the last four drinking occasions (Finnish method). Sensitivity and specificity were assessed relative to the Finnish method, for how AUDIT-Cm score (3 + for women, 4 + for men), and how subsets of AUDIT-Cm questions (AUDIT-1m and AUDIT-2m; and AUDIT-3mV alone) were able to determine short- or long-term risk from drinking. Responses to AUDIT-Cm were used to calculate the average standard drinks consumed per day, and the frequency at which more than four standard drinks were consumed on single occasions. Finally, shorter versions of the Finnish method (1, 2, or 3 occasions of drinking) were compared to the full Finnish method, by examining the percentage of variance retained by shorter versions. RESULTS: AUDIT-Cm has a high sensitivity in detecting at-risk drinking compared with the Finnish method (sensitivity = 99%, specificity = 67%). The combination of AUDIT-1m and AUDIT-2m was able to classify the drinking risk status for all but four individuals in the same way as the Finnish method did. For the Finnish method, two drinking sessions to calculate drinks per drinking occasion, and four to calculate frequency resulted in nearly identical estimates to data on all four of the most recent drinking occasions (r2 = 0.997). CONCLUSIONS: The combination of AUDIT-1m and AUDIT-2m may offer advantages as a short screening tool, over AUDIT-3mV, in groups where intermittent and high per occasion drinking is common. As an alternative to the full Finnish method, the quantity consumed on the last two occasions and timing of the last four occasions may provide a practical short screening tool.
Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial
Creators: name: Bohannon, Lauren
name: Ren, Yi
name: Andermann, Tessa M
name: Jensen, David
name: Johnson, Ernaya
name: Ramirez, Zeni E
name: Wan, Zihan
name: Jung, Sin-Ho
name: Sung, Julia A
name: Messina, Julia A
name: Racioppi, Alessandro
name: Zhao, Aaron T
name: Artica, Alexandra
name: Tang, Helen
name: Pamanes, Claudia
name: Wischmeyer, Paul E
name: Bush, Amy
name: Bergens, Matthew
name: Britt, Anne
name: Jiang, Danting
name: Lew, Meagan V
name: Surana, Neeraj K
name: Sung, Anthony D
name: Winthrop, Hilary
Publisher: name: Elsevier
Year: 2023

description:
BACKGROUND & AIMS: The COVID-19 pandemic continues to pose unprecedented challenges to worldwide health. While vaccines are effective, additional strategies to mitigate the spread/severity of COVID-19 continue to be needed. Emerging evidence suggests susceptibility to respiratory tract infections in healthy subjects can be reduced by probiotic interventions; thus, probiotics may be a low-risk, low-cost, and easily implementable modality to reduce risk of COVID-19. METHODS: In this initial study, we conducted a randomized, double-blind, placebo-controlled trial across the United States testing probiotic Lacticaseibacillus rhamnosus GG (LGG) as postexposure prophylaxis for COVID-19 in 182 participants who had household exposure to someone with confirmed COVID-19 diagnosed within ≤7 days. Participants were randomized to receive oral LGG or placebo for 28 days. The primary outcome was development of illness symptoms within 28 days of COVID-19 exposure. Stool was collected to evaluate microbiome changes. RESULTS: Intention-to-treat analysis showed LGG treatment led to a lower likelihood of developing illness symptoms versus placebo (26.4 % vs. 42.9 %, p = 0.02). Further, LGG was associated with a statistically significant reduction in COVID-19 diagnosis (log rank, p = 0.049) via time-to-event analysis. Overall incidence of COVID-19 diagnosis did not significantly differ between LGG and placebo groups (8.8 % vs. 15.4 %, p = 0.17). CONCLUSIONS: This data suggests LGG is associated with prolonged time to COVID-19 infection, reduced incidence of illness symptoms, and gut microbiome changes when used as prophylaxis ≤7 days post-COVID-19 exposure, but not overall incidence. This initial work may inform future COVID-19 prevention studies worldwide, particularly in developing nations where Lacticaseibacillus probiotics have previously been utilized to reduce other non-COVID infectious-morbidity. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04399252, Date: 22/05/2020. https://clinicaltrials.gov/ct2/show/NCT04399252.
Additional file 6 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 6: Epigenome-wide association plot for maternal 2h-post-OGTT glucose levels; Figure of epigenome-wide association plot presenting CpG sites from the LMM associated with maternal 2h-post-OGTT glucose levels.