cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assisted reproductive technology: what are the cardiovascular risks for women?
Creators: name: Guan, Carolyn
name: Rodriguez, Carla
name: Elder-Odame, Petal
name: Minhas, Anum S.
name: Zahid, Salman
name: Baker, Valerie L.
name: Shufelt, Chrisandra L.
name: Michos, Erin D.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Infertility affects 15% of women of reproductive age in the United States. The use of assisted reproductive technology (ART) has been rising globally, as well as a growing recognition of reproductive factors that increase risk for cardiovascular disease (CVD). Women with infertility who use ART are more likely to have established CVD risk factors, such as obesity, dyslipidemia, hypertension, and diabetes. They are also more likely to experience adverse pregnancy outcomes, which are associated with both peripartum and long-term cardiovascular complications. ART may lead to increased cardiometabolic demands due to ovarian stimulation, pregnancy itself, and higher rates of multifetal gestation. Preeclampsia risk appears greater with frozen rather than fresh embryo transfers. The use of ART and its association with long term CVD has not been well-studied. Future prospective and mechanistic studies investigating the association of ART and CVD risk may help determine causality. Nevertheless, CVD risk screening is critical pre-pregnancy and during pregnancy to reduce pregnancy complications that elevate future CVD risk. This also offers a window of opportunity to connect patients to longitudinal care for early management of cardiometabolic risk profile and initiation of preventive lifestyle and pharmacotherapy interventions tailored toward patient-specific risk factors.
Development of a broadband reflective T-filter for voltage biasing high-Q superconducting microwave cavities
Creators: name: Hao, Yu
name: Rouxinol, Francisco
name: LaHaye, M. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present the design of a reflective stop-band filter based on quasi-lumped elements that can be utilized to introduce large dc and low-frequency voltage biases into a low-loss superconducting coplanar waveguide (CPW) cavity. Transmission measurements of the filter are seen to be in good agreement with simulations and demonstrate insertion losses greater than $20\,{\rm dB}$ in the range of ${\rm 3\,to\,10\,GHz}$. Moreover, transmission measurements of the CPW's fundamental mode demonstrate that loaded quality factors exceeding $10^5$ can be achieved with this design for dc voltages as large as ${\rm 20\,V}$ and for the cavity operated in the single-photon regime. This makes the design suitable for use in a number of applications including qubit-coupled mechanical systems and circuit QED.
description: 4 pages, 4 figures
Free energies for refolding of the common beta turn into the inverse-common beta turn: simulation of the role of D/L chirality.
Creators: name: Tropsha, A.
name: Erickson, B. W.
name: Hermans, J.
name: Yan, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Quantitative estimates of the Gibbs free-energy change (delta G) for refolding of one beta-turn conformation into another would assist rational protein design. For beta-turn models, we studied a chirally representative set of nine peptides of the form CH3CO-L1-L2-NHCH3, where loop residues L1 (i + 1) and L2 (i + 2) are achiral Gly (G), L-Ala (A), or D-Ala (a). The stabilities of their common (type I) and inverse-common (type I') beta-turn conformers (GGI is the type-I GG conformer, etc.) were estimated by free-energy simulations using explicit water molecules. An alpha-hydrogen atom of a Gly residue at L1 or L2 was replaced by a methyl group by slow growth. The resulting conformers were less stable than GGI and GGI' by about 1-3 kcal/mol (delta G = 0.9 kcal/mol for AGI and aGI', 1.0 kcal/mol for GAI and GaI', 2.1 kcal/mol for aGI and AGI', and 2.8 kcal/mol for GaI and GAI'; 1 kcal = 4.18 kJ). The delta G value for simultaneous growth of one methyl group at L1 and another at L2 was the sum of the two component delta G values. The delta G values for I-->I' refolding of the common beta-turn conformer into the inverse-common beta-turn conformer ranged over 6 kcal/mol (-3.0 for aa, -1.8 for Ga, -1.1 for aG, -0.7 for Aa, 0 for GG, 0.7 for aA, 1.1 for AG, 1.8 for GA, and 3.0 for AA). Thus, replacing L-Ala by D-Ala at both L1 and L2 of a common beta turn may contribute as much as 6 kcal/mol toward its refolding as an inverse-common beta turn.
Genomic structure and chromosomal localization of the human deoxycytidine kinase gene.
Creators: name: Song, J. J.
name: Mitchell, B. S.
name: Johnson, E. E.
name: Chen, E.
name: Gribbin, T.
name: Spychala, J.
name: Walker, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Deoxycytidine kinase (NTP:deoxycytidine 5'-phosphotransferase, EC 1.7.1.74) is an enzyme that catalyzes phosphorylation of deoxyribonucleosides and a number of nucleoside analogs that are important in antiviral and cancer chemotherapy. Deficiency of this enzyme activity is associated with resistance to these agents, whereas increased enzyme activity is associated with increased activation of such compounds to cytotoxic nucleoside triphosphate derivatives. To characterize the regulation of expression of this gene, we have violated genomic clones encompassing its entire coding and 5' flanking regions and delineated all the exon/intron boundaries.Deoxycytidine kinase (NTP:deoxycytidine 5'-phosphotransferase, EC 1.7.1.74) is an enzyme that catalyzes phosphorylation of deoxyribonucleosides and a number of nucleoside analogs that are important in antiviral and cancer chemotherapy. Deficiency of this enzyme activity is associated with resistance to these agents, whereas increased enzyme activity is associated with increased activation of such compounds to cytotoxic nucleoside triphosphate derivatives. To characterize the regulation of expression of this gene, we have violated genomic clones encompassing its entire coding and 5' flanking regions and delineated all the exon/intron boundaries.
Independently gated multiple substates of an epithelial chloride-channel protein.
Creators: name: Dillard, M.
name: Finn, A. L.
name: Gaido, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: We have purified a protein from Necturus maculosus gallbladder cells that forms chloride channels in an artificial membrane. The same protein apparently can form channels that are highly selective for chloride but can have conductances varying from 9 to about 150 pS. The high-conductance channels are blocked by the monoclonal antibody used to purify the protein, but this antibody has no effect on the 9-pS channels. The observation that gating of the low- and high-conductance states is independent and that the antibody affects only the latter has implications regarding the control of chloride conductance in cell membranes and the different types of channels described in those cells.
Humanae vitae: Die Herausforderungen einer Aktualisierung nach 40 Jahren
Creators: name: Anjos, Márcio Fabri Dos
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 44 Nr. 1 (2008): Concilium: Internationale Zeitschrift für Theologie, Band 44, Heft 1
Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.
Creators: name: Clemmons, D. R.
name: Wright, G.
name: Busby, W. H.
name: Gockerman, A.
name: Jones, J. I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Insulin-like growth factor (IGF)-binding protein 1 (IGFBP-1) contains an Arg-Gly-Asp (RGD) integrin recognition sequence. In vitro mutagenesis was used to alter this RGD sequence to Trp-Gly-Asp (WGD). Migration of Chinese hamster ovary (CHO) cells expressing the wild-type protein was more than 3-fold greater in 48 hr compared with cells expressing the WGD mutant form of IGFBP-1. Similarly, wild-type IGFBP-1 added to the media of control CHO cells stimulated migration 2-fold compared with the WGD protein. A synthetic RGD-containing peptide, when added to the medium with wild-type IGFBP-1, blocked the effect of IGFBP-1 on cell migration. The addition of IGF-I to the culture medium had no effect on the migration of cells expressing IGFBP-1 or vector alone. Affinity chromatography of 125I-labeled CHO cell membrane proteins, using IGFBP-1 coupled to agarose, identified the alpha 5 beta 1 integrin (fibronectin receptor) as the only cell surface molecule capable of binding IGFBP-1 in an RGD-dependent manner. Furthermore, wild-type IGFBP-1, but not the WGD mutant form, could be coprecipitated from CHO cells with an antibody directed against the alpha 5 integrin subunit. These studies demonstrate that IGFBP-1 stimulates CHO cell migration and binds to the alpha 5 beta 1 integrin receptor, both by an RGD-dependent mechanism. The effect of IGFBP-1 on migration is independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin.
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
Creators: name: Shehee, W. R.
name: Smithies, O.
name: Oliver, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of a- and β-globin chains that form hemoglobin. We have disrupted the major adult β-globin gene (b1) in mouse embryonic stem cells by using homologous recombination to insert selectable sequences into the gene. Mice homozygous for this insertional disruption of the b1 gene (Hbbth-1/Hbbth-2) are severely anemic and die perinatally. In contrast, ≃60% of mice homozygous for deletion of the same gene (Hbbth-1/Hbbth-1) survive to adulthood and are much less anemic [Skow, L. C., Burkhart, B. A., Johnson, F. M., Popp, R. A., Goldberg, S. Z., Anderson, W. F., Barnett, L. B. & Lewis, S. E. (1983) Cell 34, 1043-1052].Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of a- and β-globin chains that form hemoglobin. We have disrupted the major adult β-globin gene (b1) in mouse embryonic stem cells by using homologous recombination to insert selectable sequences into the gene. Mice homozygous for this insertional disruption of the b1 gene (Hbbth-1/Hbbth-2) are severely anemic and die perinatally. In contrast, ≃60% of mice homozygous for deletion of the same gene (Hbbth-1/Hbbth-1) survive to adulthood and are much less anemic [Skow, L. C., Burkhart, B. A., Johnson, F. M., Popp, R. A., Goldberg, S. Z., Anderson, W. F., Barnett, L. B. & Lewis, S. E. (1983) Cell 34, 1043-1052].
Bayesian parameter estimation of core collapse supernovae using gravitational wave simulations
Creators: name: Edwards, Matthew C.
name: Meyer, Renate
name: Christensen, Nelson
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Using the latest numerical simulations of rotating stellar core collapse, we present a Bayesian framework to extract the physical information encoded in noisy gravitational wave signals. We fit Bayesian principal component regression models with known and unknown signal arrival times to reconstruct gravitational wave signals, and subsequently fit known astrophysical parameters on the posterior means of the principal component coefficients using a linear model. We predict the ratio of rotational kinetic energy to gravitational energy of the inner core at bounce by sampling from the posterior predictive distribution, and find that these predictions are generally very close to the true parameter values, with $90\%$ credible intervals $\sim 0.04$ and $\sim 0.06$ wide for the known and unknown arrival time models respectively. Two supervised machine learning methods are implemented to classify precollapse differential rotation, and we find that these methods discriminate rapidly rotating progenitors particularly well. We also introduce a constrained optimization approach to model selection to find an optimal number of principal components in the signal reconstruction step. Using this approach, we select 14 principal components as the most parsimonious model.
Polynomial approximation with doubling weights
Creators: name: Kopotun, Kirill A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 41A10, 41A17, 41A25, 41A27

description: Among other things, we prove that, for a doubling weight $w$, $0< p\leq\infty$, $r\in{\mathbb N}_0$, and $0
Pertemuan 4 Praktek Akuntansi Buku Besar/ Posting 27 September 2022
Creators: name: Dr. Rusdiyanto, SE,. M. Ak,. CH,. CHt
Publisher: name: Zenodo
Year: 2022
Subjects: Buku Besar, Posting, Pertemuan 4, 26, September, 2022

description: Buku Besar Dalam Perusahaan Jasa Buku besar adalah buku utama pencatatan transaksi keuangan yang mengkonsolidasikan masukan dari semua jurnal akuntansi dan merupakan penggolongan rekening yang sejenis. Hal ini dilakukan guna mempermudah dalam menganalisis kegiatan transaksi keuangan perusahaan. Pada dasarnya buku besar menjadi salah satu aspek penting karena terdapat berbagai akun untuk meringkas transaksi yang sudah dicatat pada jurnal. Jumlah perkiraan yang terdapat pada buku besar setiap perusahaan selalu berbeda-beda. Hal ini bergantung kepada kekayaan, kondisi keuangan, jenis kegiatan, volume transaksi, dan informasi yang dibutuhkan oleh perusahaan
The observational status of Galileon gravity after Planck
Creators: name: Barreira, Alexandre
name: Li, Baojiu
name: Baugh, Carlton
name: Pascoli, Silvia
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use the latest CMB data from Planck, together with BAO measurements, to constrain the full parameter space of Galileon gravity. We constrain separately the three main branches of the theory known as the Cubic, Quartic and Quintic models, and find that all yield a very good fit to these data. Unlike in $Λ{\rm CDM}$, the Galileon model constraints are compatible with local determinations of the Hubble parameter and predict nonzero neutrino masses at over $5σ$ significance. We also identify that the low-$l$ part of the CMB lensing spectrum may be able to distinguish between $Λ{\rm CDM}$ and Galileon models. In the Cubic model, the lensing potential deepens at late times on sub-horizon scales, which is at odds with the current observational suggestion of a positive ISW effect. Compared to $Λ$CDM, the Quartic and Quintic models predict less ISW power in the low-$l$ region of the CMB temperature spectrum, and as such are slightly preferred by the Planck data. We illustrate that residual local modifications to gravity in the Quartic and Quintic models may render the Cubic model as the only branch of Galileon gravity that passes Solar System tests.
description: 25 pages, 11 figures, 2 tables. Comments welcomed; v2 contains an extra appendix discussing the role of tensor perturbations
Model observers for assessment of image quality.
Creators: name: Myers, K. J.
name: Yao, J.
name: Rolland, J. P.
name: Barrett, H. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Image quality can be defined objectively in terms of the performance of some "observer" (either a human or a mathematical model) for some task of practical interest. If the end user of the image will be a human, model observers are used to predict the task performance of the human, as measured by psychophysical studies, and hence to serve as the basis for optimization of image quality. In this paper, we consider the task of detection of a weak signal in a noisy image. The mathematical observers considered include the ideal Bayesian, the nonprewhitening matched filter, a model based on linear-discriminant analysis and referred to as the Hotelling observer, and the Hotelling and Bayesian observers modified to account for the spatial-frequency-selective channels in the human visual system. The theory behind these observer models is briefly reviewed, and several psychophysical studies relating to the choice among them are summarized. Only the Hotelling model with channels is mathematically tractable in all cases considered here and capable of accounting for all of these data. This model requires no adjustment of parameters to fit the data and is relatively insensitive to the details of the channel mechanism. We therefore suggest it as a useful model observer for the purpose of assessing and optimizing image quality with respect to simple detection tasks.
Appendix to IFAM2022.0099
Creators: name: Herchenbach, Jody S.
name: Briggeman, Brian C.
name: Bergtold, Jason S.
name: Shanoyan, Aleksan
name: A. Low, Sarah
name: Miller, Brandi
Publisher: name: Brill Online
Year: 2023
Subjects: classificationCode: 300208
subject: Farm management, rural management and agribusiness

description: Questionnaires used for this study
Free function theory through matrix invariants
Creators: name: Klep, Igor
name: Špenko, Špela
Publisher: name: arXiv
Year: 2014
Subjects: subject: Rings and Algebras (math.RA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 16R30, 32A05, 46L52, 47A56, Secondary 15A24, 46G20

description: In this article we introduce powerful tools and techniques from invariant theory to free analysis. This enables us to study free maps with involution. These maps are free noncommutative analogs of real analytic functions of several variables. With examples we demonstrate that they do not exhibit strong rigidity properties of their involution-free free counterparts. We present a characterization of polynomial free maps via properties of their finite-dimensional slices. This is used to establish power series expansions for analytic free maps about scalar and non-scalar points; the latter are given by series of generalized polynomials for which we obtain an invariant-theoretic characterization. Finally, we give an inverse and implicit function theorem for free maps with involution.
description: 26 pages
STRUCTURE OF AFFIRMATIVE AND NEGATIVE SENTENCES IN UZBEKI AND TURKISH: COMMONALITIES AND DIFFERENCES
Creators: name: Abdurahimova, Nigora
Publisher: name: Zenodo
Year: 2024

description: This article aims to research common and different aspects of affirmative and negative sentences in Uzbek and Turkish languages. First of all, the problem of definition and interpretation of words in Uzbek and Turkish linguistics, which express the meaning of affirmation and negation in the compared languages, was studied. Then the adverbs and compounds that form negative sentences in both languages were compared and studied. In some situations, it is noted that the form of affirmative sentences expresses the negative meaning, and negative sentences express the affirmative meaning. That is, it was observed that in the affirmative and negative sentences of the compared languages, semantic-formal inconsistency sometimes appeared in the structure of the text. The article uses the methods of analysis, comparison, synthesis, generalization, description. As a result of the research, the common and different features of grammatical additions and tools forming affirmative and negative sentences in Uzbek and Turkish languages were studied. Also, the means of forming affirmative and negative sentences, which ensure the inconsistency of affirmation and negation from a semantic and formal point of view, are described.
Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.
Creators: name: Wing, B.
name: Baldwin, A. S.
name: Azizkhan, J. C.
name: Haskill, J. S.
name: Huang, E. S.
name: Kowalik, T. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Infection-induced activation of the human cytomegalovirus major immediate early enhancer/promoter has been shown to be regulated primarily by transcription factor NF-kappa B cis elements. However, the mechanism(s) by which human cytomegalovirus induces NF-kappa B activity is unknown. A study was therefore undertaken to determine how this virus would affect normal NF-kappa B regulation. Viral infection of fibroblasts resulted in the specific stimulation of promoters containing major histocompatibility complex NF-kappa B cis elements fused upstream of the chloramphenicol acetyltransferase reporter gene. Electrophoretic mobility shift assays of nuclear extracts derived from mock- and virus-infected cells showed dramatic and sustained increases in DNA-binding proteins specific for these NF-kappa B sequences. Experiments using MAD-3 I kappa B, a specific inhibitor of NF-kappa B, and antibodies directed against rel family members demonstrated that the induced binding activities contained p50 and p65 proteins but not c-rel. Northern analysis indicated maximal levels of p50 mRNA by 4 h postinfection, whereas p65 and MAD-3 I kappa B mRNA accumulation peaked at 48-72 h postinfection, suggesting different regulatory mechanisms for p50 and p65/I kappa B genes. Electrophoretic mobility shift assays with deoxycholate-treated cytoplasmic extracts demonstrated a 3- to 4-fold decrease in the cytosolic stores of NF-kappa B binding activity by 4 h postinfection. Western blots probed with antibodies directed against MAD-3 I kappa B or pp40 (a protein isolated from chicken with sequence and biochemical properties similar to those of MAD-3 I kappa B) indicated that a cross-reactive peptide of 39 kDa was no longer detectable after 24 h postinfection. These results demonstrate that the activation and maintenance of nuclear NF-kappa B DNA binding and enhancer activities upon human cytomegalovirus infection occurs by multiple mechanisms.
"Ein G-String-Tanga ist nicht samoanisch"
Creators: name: Culbertson, Philip Loroy
name: Maliko, Tavita
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 44 Nr. 1 (2008): Concilium: Internationale Zeitschrift für Theologie, Band 44, Heft 1
Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.
Creators: name: Kole, R.
name: Dominski, Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Antisense 2'-O-methylribooligonucleotides were targeted against specific sequence elements in mutated human beta-globin pre-mRNAs to restore correct splicing of these RNAs in vitro. The following mutations of the beta-globin gene, A-->G at nt 110 of the first intron (beta 110), T-->G at nt 705 and C-->T at nt 654 of the second intron (IVS2(705) and IVS2(654), respectively), which led to aberrant splicing of the corresponding pre-mRNAs, were previously identified as the underlying causes of beta-thalassemia. Aberrant splicing of beta 110 pre-mRNA was efficiently reversed by an oligonucleotide targeted against the branch point sequence in the first intron of the pre-mRNA but not by an oligonucleotide targeted against the aberrant 3' splice site. In both IVS2(705) and IVS2(654) pre-mRNAs, correct splicing was restored by oligonucleotides targeted against the aberrant 5' splice sites created by the mutations in the second intron or against a cryptic 3' splice site located upstream and activated in the mutated background. These experiments represent an approach in which antisense oligonucleotides are used to restore the function of a defective gene and not, as usual, to down-regulate the expression of an undesirable gene.
Correcting Errors in Digital Lexicographic Resources Using a Dictionary Manipulation Language
Creators: name: Zajic, David
name: Maxwell, Michael
name: Doermann, David
name: Rodrigues, Paul
name: Bloodgood, Michael
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: We describe a paradigm for combining manual and automatic error correction of noisy structured lexicographic data. Modifications to the structure and underlying text of the lexicographic data are expressed in a simple, interpreted programming language. Dictionary Manipulation Language (DML) commands identify nodes by unique identifiers, and manipulations are performed using simple commands such as create, move, set text, etc. Corrected lexicons are produced by applying sequences of DML commands to the source version of the lexicon. DML commands can be written manually to repair one-off errors or generated automatically to correct recurring problems. We discuss advantages of the paradigm for the task of editing digital bilingual dictionaries.
description: 5 pages, 3 figures, 1 table; appeared in Proceedings of Electronic Lexicography in the 21st Century (eLex), November 2011
Retinoic acid is a negative regulator of the Epstein-Barr virus protein (BZLF1) that mediates disruption of latent infection.
Creators: name: Pagano, J. S.
name: Liao, W.
name: Sista, N. D.
name: Kenney, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Disruption of latent Epstein-Barr virus (EBV) infection is induced by the key immediate-early protein BZLF1 (or Z, a member of the basic leucine-zipper family), which transactivates the viral early promoters. Viral reactivation is marked by renewed synthesis of early gene products such as EBV early antigen-diffuse (EA-D). Retinoic acid has been previously shown to inhibit reactivation of EBV infection. Retinoic acid responsive receptors are known to act as positively regulating transcription factors but can also negatively regulate AP-1 responsive genes. Here we demonstrate that the retinoic acid receptor a (RARα) and retinoid X receptor a (RXRα) inhibit the ability of the Z protein to transactivate the viral early promoter BMRF1, which directs transcription of EA-D.Disruption of latent Epstein-Barr virus (EBV) infection is induced by the key immediate-early protein BZLF1 (or Z, a member of the basic leucine-zipper family), which transactivates the viral early promoters. Viral reactivation is marked by renewed synthesis of early gene products such as EBV early antigen-diffuse (EA-D). Retinoic acid has been previously shown to inhibit reactivation of EBV infection. Retinoic acid responsive receptors are known to act as positively regulating transcription factors but can also negatively regulate AP-1 responsive genes. Here we demonstrate that the retinoic acid receptor a (RARα) and retinoid X receptor a (RXRα) inhibit the ability of the Z protein to transactivate the viral early promoter BMRF1, which directs transcription of EA-D.
Lie algebroids generated by cohomology operators
Creators: name: García-Beltrán, D.
name: Vallejo, J. A.
name: Vorobiev, Yu.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 58F15 (Primary), 58F17, 53C35 (Secondary)

description: By studying the Frölicher-Nijenhuis decomposition of cohomology operators (that is, derivations $D$ of the exterior algebra $Ω(M)$ with $\mathbb{Z}-$degree $1$ and $D^2=0$), we describe new examples of Lie algebroid structures on the tangent bundle $TM$ (and its complexification $T^{\mathbb{C}}M$) constructed from pre-existing geometric ones such as foliations, complex, product or tangent structures. We also describe a class of Lie algebroids on tangent bundles associated to idempotent endomorphisms with nontrivial Nijenhuis torsion.
description: Second version
Reengineering observatory operations for the time domain
Creators: name: Seaman, Robert L.
name: Vestrand, W. Thomas
name: Hessman, Frederic V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Observatories are complex scientific and technical institutions serving diverse users and purposes. Their telescopes, instruments, software, and human resources engage in interwoven workflows over a broad range of timescales. These workflows have been tuned to be responsive to concepts of observatory operations that were applicable when various assets were commissioned, years or decades in the past. The astronomical community is entering an era of rapid change increasingly characterized by large time domain surveys, robotic telescopes and automated infrastructures, and - most significantly - of operating modes and scientific consortia that span our individual facilities, joining them into complex network entities. Observatories must adapt and numerous initiatives are in progress that focus on redesigning individual components out of the astronomical toolkit. New instrumentation is both more capable and more complex than ever, and even simple instruments may have powerful observation scripting capabilities. Remote and queue observing modes are now widespread. Data archives are becoming ubiquitous. Virtual observatory standards and protocols and astroinformatics data-mining techniques layered on these are areas of active development. Indeed, new large-aperture ground-based telescopes may be as expensive as space missions and have similarly formal project management processes and large data management requirements. This piecewise approach is not enough. Whatever challenges of funding or politics facing the national and international astronomical communities it will be more efficient - scientifically as well as in the usual figures of merit of cost, schedule, performance, and risks - to explicitly address the systems engineering of the astronomical community as a whole.
description: SPIE 2014 Astronomical Telescopes + Instrumentation, Observatory Operations: Strategies, Processes, and Systems V, Proc. SPIE 9149-5
Roles of the six peptide-binding pockets of the HLA-A2 molecule in allorecognition by human cytotoxic T-cell clones.
Creators: name: Frelinger, J. A.
name: Matsui, M.
name: Hioe, C. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: To evaluate the contribution of the major histocompatibility complex class I pockets to the binding of self-peptides recognized by alloreactive cytotoxic T-lymphocyte (CTL) clones, we have constructed an extensive library of HLA-A2 mutants with different amino acid substitutions in each of the six pockets. When these mutants were tested in cytotoxicity assays with a panel of HLA-A2-specific alloreactive CTL clones, each CTL clone showed a unique pattern of reactivity, implying the different contributions of each pocket to binding individual peptides. We noted that the majority of the mutants in pocket B significantly affect recognition by the CTL clones. Unexpectedly, the mutations influencing allorecognition are found in all other pockets as well. Overall, this study demonstrates that each of the six peptide-binding pockets plays an important and distinct role in binding of self-peptides required for recognition of the HLA-A2 molecule by alloreactive CTLs.
NLO Vertex for a Forward Jet plus a Rapidity Gap at High Energies
Creators: name: Hentschinski, Martin
name: Martínez, José Daniel Madrigal
name: Murdaca, Beatrice
name: Vera, Agustín Sabio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the calculation of the forward jet vertex associated to a rapidity gap (coupling of a hard pomeron to the jet) in the BFKL formalism at next-to-leading order (NLO). Real emission contributions are computed via Lipatov's effective action. The NLO jet vertex turns out to be finite within collinear factorization and allows, together with the NLO non-forward gluon Green's function, to perform NLO studies of jet production in diffractive events (e.g. Mueller-Tang dijets).
description: 4 pages, Proceedings of DIFFRACTION 2014 (Primo\v{s}ten, Croatia, September 2014)
The Secret Life of Writing: A Holistic Palaeography Project
Creators: name: Castro Correa, Ainoa
Publisher: name: Zenodo
Year: 2021
Subjects: Paleography
Palaeography
Manuscript Studies
Medieval History
Visigothic script

description: Presentation and draft text of the talk presented at the Medieval Manuscripts Seminars, Institute of English Studies-School of Advanced Study University of London series 2020-2021.
Systemic immunological effects of cytokine genes injected into skeletal muscle.
Creators: name: Raz, E.
name: Baird, S. M.
name: Carson, D. A.
name: Kipps, T. J.
name: Watanabe, A.
name: Lotz, M.
name: Parr, T. B.
name: Eisenberg, R. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Somatic gene therapy is an interesting approach for the delivery of cytokines for prolonged periods. The present experiments show that direct injections into mouse skeletal muscle of cDNA expression vectors encoding interleukin 2 (IL-2), IL-4, or type beta 1 transforming growth factor (TGF-beta 1) induce biological effects characteristic of these cytokines in vivo. Mice injected intramuscularly with a vector encoding IL-2 had enhanced humoral and cellular immune responses to an exogenous antigen, transferrin, that was delivered at a separate site. These IL-2 effects were abolished by coadministration of a vector directing synthesis of TGF-beta 1. The TGF-beta 1 vector by itself depressed the anti-transferrin antibody response and caused an 8-fold increase in plasma TGF-beta 1 activity. The TGF-beta 1 plasmid injection did not cause muscle infiltration with monocytes or neutrophils and there was no evidence for fibrotic changes. Muscle injection with a cDNA encoding IL-4 selectively increased IgG1 levels but did not alter the cellular immune response to transferrin. In lupus-prone mice (MRL/lpr/lpr), injection with IL-2 expression vectors increased and TGF-beta 1 vectors decreased auto-antibodies to chromatin. These results demonstrate that intramuscular injection of cytokine genes, in the absence of infectious viral vectors, can regulate humoral and cellular immune responses in vivo.
The Magneto Hydro Dynamical Model of KHz Quasi Periodic Oscillations in Neutron Star Low Mass X-ray Binaries (II)
Creators: name: Shi, Chang-Sheng
name: Zhang, Shuang-Nan
name: Li, Xiang-Dong
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the kilohertz quasi-periodic oscillations (kHz QPOs) in neutron star low mass X-ray binaries (LMXBs) with a new magnetohydrodynamics (MHD) model, in which the compressed magnetosphere is considered. The previous MHD model (Shi \& Li 2009) is re-examined and the relation between the frequencies of the kHz QPOs and the accretion rate in LMXBs is obtained. Our result agrees with the observations of six sources (4U 0614+09, 4U 1636--53, 4U 1608--52, 4U 1915--15, 4U 1728--34, XTE 1807--294) with measured spins. In this model the kHz QPOs originate from the MHD waves in the compressed magnetosphere. The single kHz QPOs and twin kHz QPOs are produced in two different parts of the accretion disk and the boundary is close to the corotation radius. The lower QPO frequency in a frequency-accretion rate diagram is cut off at low accretion rate and the twin kHz QPOs encounter a top ceiling at high accretion rate due to the restriction of innermost stable circular orbit.
description: 24 pages, 8 figures, 1 table. Accepted for publication in The Astrophysical Journal and tentatively scheduled for the August 10, 2014, V791 - 1 issue
Analysis of $J/ψ(η_c)\to γ~+$ invisible decays in the standard model
Creators: name: Gao, Dao-Neng
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Motivated by the experimental study of $J/ψ\toγ~+$ invisible decay by the CLEO Collaboration, we analyze the process $J/ψ\to γν\barν$, as the standard model background for this invisible decay, at the lowest order. Our investigation shows that Br($J/ψ\to γν\barν$) is far below the present experimental upper limit on the branching ratio of $J/ψ\toγ~+$ invisible, which indicates that some interesting room for new physics in this channel might be expected. We also present a similar analysis of the $η_c\to γν\barν$ decay.
description: 7 pages, 4 figures. An appendix added, published version
The rhetoric of humour in Arabic comedy : countering violent extremism and politicisation of religion
Creators: name: Alkheder, Moutaz
Publisher: name: The University of St Andrews
Year: 2023
Subjects: subject: Rhetoric
subject: Humour
subject: Comedy
subject: Countering violent extremism (CVE)
subject: Counterterrorism
subject: Terrorism
subject: Narrative
subject: Spotlight (Buq’at Ḍawʾ)
subject: The Programme (Al-Barnāmij)
subject: HV6433.M5A6
subject: Terrorism--Prevention
subject: Arabic wit and humor
subject: Humor in Islam
subject: Television programs--Egypt--History--21st century
subject: Television programs--Syria--History--21st century.

description: This thesis explores a relatively recent phenomenon in the Arab world: the use of humour as a counternarrative to the propaganda disseminated by violent extremist groups, particularly 'The Islamic State,' and as a response to the political instrumentalisation of religion by religiopolitical movement, exemplified by the Muslim Brotherhood in Egypt. The primary focus of this research centres on mainstream comedy programs, specifically "Buqʿat Ḍawʾ" (Spotlight) and "al-Barnāmij" (The Programme). The central inquiry underlying this study pertains to the capacity of humour to function as a rhetorical tool, a distinct form of persuasion aimed at reshaping perspectives and attitudes. In light of notable gaps in the existing academic literature, this thesis presents a multifaceted and interdisciplinary theoretical framework, with rhetoric serving as the primary guiding theory. The framework harmoniously synthesizes classical rhetoric with humour research, incorporates insights from contemporary scientific research on emotions to explain the persuasive role of emotions, and draws from the field of argumentation studies to inform the manner in which humour can effectively construct an argument. The primary conclusion of this study is that rhetorical humour can serve as a valuable instrument within the communication model for countering violent extremism (CVE). It advocates for the utilization of rhetorical strategies, as opposed to logic-centric approaches, positing that such strategies may yield more favourable outcomes in the context of countering violent extremism. The study underscores the practical significance of rhetoric, as it employs non-argumentative persuasive methods, thereby addressing the intricate emotional, social, and ideological underpinnings of radicalization. Rhetorical humour, in this regard, emerges as a justified "response in kind" to the emotionally charged persuasive appeal of extremist narratives, rendering it a suitable tool for mitigating the risk of radicalization among susceptible individuals.
title: Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model
Creators: name: Grotz, Melanie
name: Gijzel, Lieke van
name: Bitsch, Peter
name: Carrara, Stefania C.
name: Kolmar, Harald
name: Garg, Sakshi
Publisher: name: Frontiers Media S.A.
Year: 2024

description: Targeting the tumor microenvironment (TME) is an attractive strategy for cancer therapy, as tumor cells in vivo are surrounded by many different influential cell types, with complex interactions strongly affecting tumor progression and therapeutic outcome. Cancer-associated fibroblasts (CAFs) represent an abundant stromal cell type in the TME that modulate tumor development by exerting an immunosuppressive effect to influence effector immune cell activation. One promising target for TME-directed therapy is the CAF marker fibroblast activation protein-α (FAP). In this study, we employ a multicellular three-dimensional (3D) spheroid model, including tumor cells, fibroblast cells, and naïve T cells and could observe a protective effect of fibroblasts on tumor cells. Subsequently, we demonstrate that fibroblasts express FAP at differing expression levels in two-dimensional (2D) versus 3D cells. Lastly, we show that in a triple-culture of tumor cells, T cells and fibroblasts, the simultaneous assembly of fibroblasts using the high-affinity ligand oncoFAP with an engineered α-CD3-scFv-Fc-dextran-oncoFAP construct resulted in effective T cell activation to augment immunogenicity. Overall, this model can be routinely used for preclinical screening to study the effects of fibroblasts on the TME in vitro.
Frauen und Kinder vor sozialen Konflikten und Naturkatastrophen in Indonesien
Creators: name: Mangunsong, Frieda
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 43 Nr. 5 (2007): Concilium: Internationale Zeitschrift für Theologie, Band 43, Heft 5
Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.
Creators: name: Lee, D.
name: Maeda, N.
name: Smith, T. J.
name: Homanics, G. E.
name: Zhang, S. H.
name: Young, S. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Familial hypobetalipoproteinemia is an autosomal codominant disorder resulting in a dramatic reduction in plasma concentrations of apolipoprotein (apo) B, cholesterol, and beta-migrating lipoproteins. A benefit of hypobetalipoproteinemia is that mildly affected individuals may be protected from coronary vascular disease. We have used gene targeting to generate mice with a modified Apob allele. Mice containing this allele display all of the hallmarks of human hypobetalipoproteinemia: they produce a truncated apoB protein, apoB70, and have markedly decreased plasma concentrations of apoB, beta-lipoproteins, and total cholesterol. In addition, the mice manifest several characteristics that are occasionally observed in human hypobetalipoproteinemia, including reduced plasma triglyceride concentrations, fasting chylomicronemia, and reduced high density lipoprotein cholesterol. An unexpected finding is that the modified Apob allele is strongly associated with exencephalus and hydrocephalus. These mice should help increase our understanding of hypobetalipoproteinemia, atherogenesis, and the etiology of exencephalus and hydrocephalus.
Supplementary material to JEMCA 20230005: Efficacy of biological larvicide VectoMax® FG against Aedes albopictus and Culex pipiens under field conditions in urban catch basins
Creators: name: Ravasi, D.
name: Parrondo Monton, D.
name: Tanadini, M.
name: Campana, V.
name: Flacio, E.
Publisher: name: Brill Online
Year: 2023
Subjects: classificationCode: 420203
subject: Environmental epidemiology
classificationCode: 300909
subject: Veterinary parasitology

description: The invasive Asian tiger mosquito Aedes albopictus appeared in southern Switzerland in 2003 and is currently well established in most of its urban regions. In public areas, the control measures against the mosquito focus on its aquatic phase with removal of breeding sites and applications of larvicides at sites that cannot be eliminated. Larvicidal products are applied mainly to catch basins, one of the major sites of oviposition for both Ae. albopictus and Culex pipiens in urban areas. We evaluated the efficacy of a larvicidal formulation (i.e. VectoMax® FG), combing the action of spore-forming bacteria Bacillus thuringiensis var. israelensis and Lysinibacillus sphaericus, against Ae. albopictus, Cx. pipiens and non-target organisms present in urban catch basins. We used floating adult emergence traps to compare the number of adults emerging from 38 catch basins treated once during the study period with ten untreated (control) catch basins. The catch basins were monitored for 21 weeks and the efficacy was evaluated fitting a Generalised Additive Mixed Model (GAMM). The efficacy of the treatment varied among species. It was high against Cx. pipiens (100% reduction in emerging adults at maximal efficacy) and lower against Ae. albopictus (60% reduction). This suggests that it is important to examine target species separately when evaluating the efficacy of larvicidal products. The product showed a long residual larvicidal activity with the number of emerging adults still being reduced by 75% for Cx. pipiens and 60% for Ae. albopictus at ten weeks after the treatment. We also observed that the maximal efficacy of the product was reached about two weeks after the treatment. The effect on non-target organisms, specifically, chironomids, was also strong (80% reduction). However, their numbers raised again rather quickly (i.e. after two weeks), and the effect vanished around week 11.
Lebensalter und christlicher Glaube unter Ordensleuten und ehemaligen Ordensleuten
Creators: name: Blasi, Anthony J.
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 43 Nr. 5 (2007): Concilium: Internationale Zeitschrift für Theologie, Band 43, Heft 5
The genetic basis of Weber-Cockayne epidermolysis bullosa simplex.
Creators: name: Fuchs, E.
name: Yu, Q. C.
name: Chan, Y. M.
name: Fine, J. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Epidermolysis bullosa simplex (EBS) is a group of autosomal dominant skin diseases characterized by blistering, due to mechanical-stress-induced degeneration of basal epidermal cells. Recently, it was discovered that the more severe types, Dowling-Meara and Koebner, are genetic disorders of the basal epidermal keratins, keratin 5 (K5) and keratin 14 (K14). Here, we show that the mildest type of EBS, Weber-Cockayne, is also a disorder of these keratins. Affected members of two unrelated families with Weber-Cockayne EBS had a T → G point mutation in the second base position of codon 161 of one of two K5 alleles, leading to an Ile → Ser mutation. This mutation was not present in unaffected members or in 156 alleles from normal individuals. Linkage analyses mapped the defect to the type II keratin gene cluster on chromosome 12q11-q13 (peak logarithm of odds score at θ = 0 of 3.0), providing strong additional evidence that this mutation is responsible for the Weber-Cockayne EBS phenotype. Conserved among type II keratins, Ile-161 is in the nonhelical head domain of K5, a region previously shown to be important for 10-nm filament assembly. The mutation generates a potential substrate site for protein kinase C, which could influence intermediate filament architecture, perhaps leading to the intrafilament association seen ultrastructurally in patients with the mutation.