cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combination of bendamustine-azacitidine against Syk target of breast cancer: an in silico study
Creators: name: Muthumanickam, Sankar
name: Ramachandran, Balajee
name: Boomi, Pandi
name: Jeyakanthan, Jeyaraman
name: Prabu, Halliah Gurumallesh
name: Jegatheswaran, Sonamuthu
name: Premkumar, Kumpati
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Breast cancer (BC) is the most serious and second leading cause of death in women worldwide. When breast cancer is diagnosed and treated early, the chance of long-term survival is up to 90%. On the other hand, 90% of BC patient deaths are due to metastasis and a lack of effective early diagnosis. The existing conventional chemotherapy provides negative feedback due to transportation barriers towards the action sites, multidrug resistance, poor bio-availability, non-specific delivery and systemic side effects on the healthy tissue. Syk protein Kinase has been reported in BC, as a tumor modulator, providing a pro-survival signal and also by restricting epithelial-mesenchymal transition, enhancing cell-cell interactions and inhibiting migration. In the present study, we explored the possibility of targeting BC by attenuating Syk protein Kinase. Hence, we have conjugated the hydrophobic Bendamustine (BEN) and hydrophilic Azacitidine (AZA) anticancer drugs to evaluate their efficacy against BC. The native drugs (BEN and AZA) and designed drug-drug conjugate (BEN-AZA) were docked with Syk protein. Then, the docked complex was performed for Binding Free Energy and Molecular Dynamics Simulations. Furthermore, DFT and ADME properties were carried out. The results revealed that the designed drug-drug conjugate has a better docking score, ΔGbind and admirable stability throughout the simulation when compared with native drugs. In DFT and ADME analyses, the designed drug-drug conjugate has shown good stereo electronic features and pharmaceutical relevant parameters than that of native drugs. The overall results suggested that the designed drug-drug conjugate may be a suitable candidate for BC treatment. Communicated by Ramaswamy H. Sarma
A refinement of the local class field theory of Serre and Hazewinkel
Creators: name: Suzuki, Takashi
name: Yoshida, Manabu
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11S31

description: We give a refinement of the local class field theory of Serre and Hazewinkel. This refinement allows the theory to treat extensions that are not necessarily totally ramified. Such a refinement was obtained and used in the authors' paper on Fontaine's property (Pm), where the explanation had to be rather brief. In this paper, we give a complete account, from necessary knowledge of an appropriate Grothendieck site to the details of the proof. We start by reviewing the local class field theory of Serre and Hazewinkel.
description: 29 pages, final version to appear in Algebraic Number Theory and Related Topics 2010, 163--191, RIMS K\^oky\^uroku Bessatsu, B32, Res. Inst. Math. Sci. (RIMS), Kyoto, 2012
Wigner's friend's memory and the no-signaling principle
Creators: name: Baumann, Veronika
name: Brukner, Časlav
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Wigner's friend experiment is a thought experiment in which a so-called superobserver (Wigner) observes another observer (the friend) who has performed a quantum measurement on a physical system. In this setup Wigner treats the friend, the system and potentially other degrees of freedom involved in the friend's measurement as one joint quantum system. In general, Wigner's measurement changes the internal record of the friend's measurement result such that after the measurement by the superobserver the result stored in the observer's memory register is no longer the same as the result the friend obtained initially, i.e. before she was measured by Wigner. Here, we show that any awareness by the friend of this change of her memory, which can be modeled by an additional register storing the information about the change, conflicts with the no-signaling condition in extended Wigner-friend scenarios.
Non-Kahler heterotic rotations
Creators: name: Martelli, Dario
name: Sparks, James
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study a supersymmetry-preserving solution-generating method in heterotic supergravity. In particular, we use this method to construct one-parameter non-Kahler deformations of Calabi-Yau manifolds with a U(1) isometry, in which the complex structure remains invariant. We explain how to obtain corresponding solutions to heterotic string theory, up to first order in α', by a modified form of the standard embedding. In the course of the paper we also show that Abelian heterotic supergravity embeds into type II supergravity, and note that the solution-generating method in this context is related to a dipole-type deformation when there is a field theory dual.
description: 42 pages; v2: references added
title: Multimodal approach for reduction of x-ray radiation in pediatric hospital practice
Creators: name: Hambardzumyan, Andrias
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Safety
subject: Equipment
subject: Diagnostic procedure
subject: Ultrasound
subject: Digital radiography
subject: CT-High Resolution
subject: Radioprotection / Radiation dose
subject: Paediatric
subject: Biological effects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To keep the radiation dose as low as reasonably achievable (ALARA) is important in general and more important in pediatric radiology practice. [1,2]. Some researcher is trying to evaluate the effects of lowering the detector entrance exposure in...
Frobenius distributions of low dimensional abelian varieties over finite fields
Creators: name: Arango-Piñeros, Santiago
name: Bhamidipati, Deewang
name: Sankar, Soumya
Publisher: name: arXiv
Year: 2023
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Given a $g$-dimensional abelian variety $A$ over a finite field $\mathbf{F}_q$, the Weil conjectures imply that the normalized Frobenius eigenvalues generate a multiplicative group of rank at most $g$. The Pontryagin dual of this group is a compact abelian Lie group that controls the distribution of high powers of the Frobenius endomorphism. This group, which we call the Serre--Frobenius group, encodes the possible multiplicative relations between the Frobenius eigenvalues. In this article, we classify all possible Serre--Frobenius groups that occur for $g \le 3$. We also give a partial classification for simple ordinary abelian varieties of prime dimension $g>3$.
description: Fixed typesetting bug from v3
Influence of socio-cultural factors and gender on waste behaviour of travellers: Insights from 11 touristic destinations in Europe
Creators: name: Luca, Claudia De
name: Louw, Erik
name: Große, Juliane
name: Buckingham, Susan
name: Romein, Arie
name: Fertner, Christian
Publisher: name: Zenodo
Year: 2019
Subjects: waste management
waste prevention
waste behaviour
tourism
municipal waste

description: In the course of a global increase of tourism, the need to deal with waste generation, management and prevention caused by tourism activities requires increased attention. In this regard, tourists’ behaviour is a crucial factor for improving the efficacy and efficiency of the waste strategies in place.

Tourists’ behaviour has been extensively studied in terms of environmental awareness, while less attention has been given to behaviour and attitudes of tourists in terms of waste generation and prevention. Especially, the socio-cultural and gender component have been hardly addressed in available research. There is some evidence about differences in environmental attitudes and behaviour between tourists from different countries of origin, just as there is evidence of different attitudes towards the environment between men and women, but these two sets of evidences are not integrated, and certainly not with regard to waste behaviour.

The present study was developed as part of the H2020 project “URBANWASTE” that aims at understanding the influence of tourism on waste management and production and at developing eco-innovative and gender sensitive strategies for waste prevention and management in 11 European pilot cases.

Particularly, this study aimed at analysing and understanding the role and effect of socio-cultural factors (e.g. place of residence, age, education) and gender on ‘waste behaviour’ of tourists; the study includes the tourists’ behaviour at home in comparison to their behaviour on holidays and accounts, hence, also for ‘behavioural gaps’ between home- vs. holiday-behaviour.
A Data-Driven Approach to Lightweight DVFS-Aware Counter-Based Power Modeling for Heterogeneous Platforms
Creators: name: Mazzola, Sergio
name: Benz, Thomas
name: Forsberg, Björn
name: Benini, Luca
Publisher: name: arXiv
Year: 2023
Subjects: subject: Performance (cs.PF)
subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: Computing systems have shifted towards highly parallel and heterogeneous architectures to tackle the challenges imposed by limited power budgets. These architectures must be supported by novel power management paradigms addressing the increasing design size, parallelism, and heterogeneity while ensuring high accuracy and low overhead. In this work, we propose a systematic, automated, and architecture-agnostic approach to accurate and lightweight DVFS-aware statistical power modeling of the CPU and GPU sub-systems of a heterogeneous platform, driven by the sub-systems' local performance monitoring counters (PMCs). Counter selection is guided by a generally applicable statistical method that identifies the minimal subsets of counters robustly correlating to power dissipation. Based on the selected counters, we train a set of lightweight, linear models characterizing each sub-system over a range of frequencies. Such models compose a lookup-table-based system-level model that efficiently captures the non-linearity of power consumption, showing desirable responsiveness and decomposability. We validate the system-level model on real hardware by measuring the total energy consumption of an NVIDIA Jetson AGX Xavier platform over a set of benchmarks. The resulting average estimation error is 1.3%, with a maximum of 3.1%. Furthermore, the model shows a maximum evaluation runtime of 500 ns, thus implying a negligible impact on system utilization and applicability to online dynamic power management (DPM).
Vibrational spectroscopy simulation of solvation effects on a G-quadruplex
Creators: name: Moscato, Davide
name: Gabas, Fabio
name: Conte, Riccardo
name: Ceotto, Michele
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: It is commonly believed that solvation effects on the vibrational properties of a solute are easily accounted for by simple rules of thumbs, that is, solvating a polar molecule in a polar medium has the only effect of red shifting all its spectroscopical features and, similarly, solvating a polar molecule in a nonpolar medium has the opposite effect. In this work, we use theoretical vibrational spectroscopy at quasi-classical and quantum approximate semiclassical level to gain atomistic insights about solvent–solute interactions for 2′-deoxyguanosine and the G-quadruplex. We employ the quasi-classical trajectory method to include full anharmonicity into our calculated spectra, and then introduce quantum nuclear effects by means of divide-and-conquer semiclassical spectroscopy calculations. Solvation is treated explicitly leading to a good reproducibility of the available experimental data and reliable predictions when an experimental reference is missing. Communicated by Ramaswamy H. Sarma
"The horrific struggle to establish a human self" : the hideous immanence of David Foster Wallace's Brief interviews with hideous men
Creators: name: Fairbairn, Isaac
Publisher: name: University of British Columbia
Year: 2022

description: David Foster Wallace’s fiction is haunted by the spectral threats of solipsism and narcissism, evidence of a career-long preoccupation with the isolation and suffering of the modern subject. In the large body of scholarship amassed by Wallace's work a critical axiom has emerged that his artistic project is ultimately redemptive, committed to upholding the values of compassion, authenticity, and empathy in the face of a prevalent alienation, extensively and disturbingly depicted, resulting from the ironic distance, paralyzing self-consciousness, and crushing boredom endemic to contemporary U.S. society. Adam Kelly, despite authoring the hugely influential paper responsible for Wallace’s association with New Sincerity, intriguingly concludes his 2016 review of Wallace criticism by suggesting its overwhelming stress on the "affirmative quality” of Wallace’s work risks failing to “capture the darker side of Wallace's dialectic, the bleaker aspects of his vision," which may, "in the end, be the most productive to consider” ("Critical" 59). Taking up Kelly’s charge, my thesis will explore Wallace's short story cycle Brief Interviews with Hideous Men and argue for its investment in a different, less straightforwardly affirmative conceptual framework: the philosophy of immanence. To rehabilitate the redemptive conception of immanent experience typically ascribed to Wallace's fiction, I turn to some key pieces of his non-fiction to suggest that Wallace conceives of immanence as a deeply uncomfortable affective state in which the structured modes of understanding that typically organize reality are violently stripped away. Finally, I argue that Brief Interviews is not just invested in the darkness and terror of immanent social life but is itself darkly terrifying: its interrogative and antagonistic relationship with the reader repeatedly functions to disturb, communicating the uncomfortable uncertainty of immanent experience as a lived emotional reality.
Supplementary Information from Performance of goats in a detour and a problem-solving test following long-term cognitive test exposure
Creators: name: Rosenberger, K.
name: Simmler, M.
name: Langbein, J.
name: Keil, N.
name: Nawroth, C.
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Description of cognitive tests, treatments and supplementary tables
Unconventional plasmon-phonon coupling in graphene
Creators: name: Jablan, M.
name: Soljačić, M.
name: Buljan, H.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We calculate hybridization of plasmons and intrinsic optical phonons in graphene by using the self-consistent linear response formalism. We find that longitudinal plasmons (transverse magnetic modes) couple exclusively to transverse optical phonons, whereas graphene's transverse plasmons (transverse electric modes) couple only to longitudinal optical phonons. This mixing of polarizations is in contrast to the usual plasmon-phonon coupling in other systems. The resulting change in phonon frequencies increases (decreases) for transverse (longitudinal) phonons by increasing the concentration of charge carriers.
Cluster structures on quantum coordinate rings
Creators: name: Geiss, C.
name: Leclerc, B.
name: Schröer, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We show that the quantum coordinate ring of the unipotent subgroup N(w) of a symmetric Kac-Moody group G associated with a Weyl group element w has the structure of a quantum cluster algebra. This quantum cluster structure arises naturally from a subcategory C_w of the module category of the corresponding preprojective algebra. An important ingredient of the proof is a system of quantum determinantal identities which can be viewed as a q-analogue of a T-system. In case G is a simple algebraic group of type A, D, E, we deduce from these results that the quantum coordinate ring of an open cell of a partial flag variety attached to G also has a cluster structure.
description: v2: minor corrections. v3: references updated, final version to appear in Selecta Mathematica
EFT for Soft Drop Double Differential Cross Section
Creators: name: Pathak, Aditya
name: Stewart, Iain W.
name: Vaidya, Varun
name: Zoppi, Lorenzo
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020
Subjects: * Automatic Keywords *
jet: mass
correction: hadronization
numerical calculations: Monte Carlo
differential cross section
effective field theory
factorization
coherence

description: We develop a factorization framework to compute the double differential cross section in soft drop groomed jet mass and groomed jet radius. We describe the effective theories in the large, intermediate, and small groomed jet radius regions defined by the interplay of the jet mass and the groomed jet radius measurement. As an application we present the NLL$'$ results for the perturbative moments that are related to the coefficients $C_1$ and $C_2$ that specify the leading hadronization corrections up to three universal parameters. We compare our results with Monte Carlo simulations and a calculation using the coherent branching method.
Analyzing the success of T-matrix diagrammatic theories in representing a modified Hubbard model
Creators: name: Pisarski, P.
name: Gooding, R. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a systematic study of various forms of renormalization that can be applied in the calculation of the self-energy of the Hubbard model within the T-matrix approximation. We compare the exact solutions of the attractive and repulsive Hubbard models, for linear chains of lengths up to eight sites, with all possible taxonomies of the T-matrix approximation. For the attractive Hubbard model, the success of a minimally self-consistent theory found earlier in the atomic limit (Phys. Rev. B 71, 155111 (2005)) is not maintained for finite clusters unless one is in the very strong correlation limit. For the repulsive model, in the weak correlation limit at low electronic densities -- that is, where one would expect a self-consistent T-matrix theory to be adequate -- we find the fully renormalized theory to be most successful. In our studies we employ a modified Hubbard interaction that eliminates all Hartree diagrams, an idea which was proposed earlier (Phys. Rev. B 63, 035104 (2000)).
description: Includes modified discussion of 1st-order phase transition. Accepted for publication in J. Phys.: Condensed Matter
Möbius transformations and electronic transport properties of large disorderless networks
Creators: name: Jiang, Yu
name: Martínez-Mares, M.
name: Castaño, E.
name: Robledo, A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We show that the key transport states, insulating and conducting, of large regular networks of scatterers can be described generically by negative and zero Lyapunov exponents, respectively, of Möbius maps that relate the scattering matrix of systems with successive sizes. The conductive phase is represented by weakly chaotic attractors that have been linked with anomalous transport and ergodicity breaking. Our conclusions, verified for serial as well as parallel stub and ring structures, reveal that mesoscopic behavior results from a drastic reduction of degrees of freedom.
description: latex, 5 figs, more specific title, abstract, and introduction, some sentences removed, references changed and added
Venetoclax analogs as promising anticancer therapeutics via targeting Bcl-2 protein: in-silico drug discovery study
Creators: name: Almansour, Nahlah Makki
name: Allemailem, Khaled S.
name: Aty, Abeer Abas Abd El
name: Boussoufa, Dhouha
name: Fagiree, Ekram Ismail
name: Ibrahim, Mahmoud A. A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: B-cell lymphoma 2 (Bcl-2) protein plays a vital role in enhancing malignant cell survival by alleviating programmed cell death. Therefore, Bcl-2 protein has been identified as a charming druggable target for cancer treatment. Venetoclax has enticed considerable attention as a potential Bcl-2 inhibitor. Herein, in-silico computations were executed to search for new venetoclax analogs against the Bcl-2 protein. A library involving 4112 was collected, prepared, and virtually screened against Bcl-2 protein using AutoDock Vina1.1.2 software. Promising analogs in complex with Bcl-2 protein were further submitted to molecular dynamics (MD) simulations, pursued by binding energy computations using the MM-GBSA approach. Compared to venetoclax (ΔGbinding = −51.2 kcal/mol), PubChem-873-158-83 and PubChem-148-422-478 demonstrated greater binding affinities with Bcl-2 protein throughout 100 ns MD simulations with ΔGbinding values of −69.1 and −62.4 kcal/mol, respectively. Structural and energetical analyses unveiled good stabilization of the identified analogs complexed with Bcl-2 protein over the MD course. The pharmacokinetic features of the two identified analogs were anticipated and unveiled the oral bioavailability of these compounds. Further in-vitro/in-vivo biological evaluations around these compounds could assist in identifying anticancer leads towards Bcl-2 protein. Communicated by Ramaswamy H. Sarma
Spin structure of the pion from the instanton vacuum
Creators: name: Nam, Seung-il
name: Kim, Hyun-Chul
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences
subject: 81V35

description: We investigate the spin structure of the pion within the framework of the nonlocal chiral quark model from the instanton vacuum. We first evaluate the tensor form factors of the pion for the first and second moment (n=1,2) and compare it with the lattice data. Combining the tensor form factor of the pion with the electromagnetic one, we determine the impact-parameter dependent probability density of transversely polarized quarks inside the pion. It turns out that the present numerical results for the tensor form factor as well as those for the probability density are in good agreement with the lattice data. We also discuss the distortion of the spatial distribution of the quarks in the transverse plane inside the pion.
description: 9 pages, 10 figures, accepted for publication in Phys. Lett. B
In silico discovery of potent inhibitors against monkeypox’s major structural proteins
Creators: name: Lokhande, Kiran Bharat
name: Shrivastava, Ashish
name: Singh, Ashutosh
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Monkeypox virus (MPXV) outbreak in non-endemic countries is a worldwide public health emergency. An enveloped double-stranded DNA virus belongs to the genus Orth poxvirus. A viral zoonotic infection known as monkeypox has been a serious risk to public health, especially in Africa. However, it has recently spread to other continents, so it might soon become a worldwide problem. There is an increased risk of transmission of the virus because there is a lack of effective treatment that cures the disease. To stop the multi-country outbreak from spreading, it is important to discover effective medications urgently. The objective of the current study is to swiftly find new treatments for the monkeypox virus using advanced computational approaches. By investigating five potential MPXV targets (DNA ligase, Palmytilated Extracellular Enveloped Virus (EEV) membrane protein, Scaffold protein D13, Thymidylate Kinase, and Viral core cysteine proteinase), this research was carried out using cutting-edge computational techniques against human monkeypox virus infection. Here we present the accurate 3D structures and their binding cavities of the selected targets with higher confidence using AlphaFold 2 and SiteMap analysis. Molecular docking and MD simulation analysis revealed the top five potential lead compounds with higher binding affinity and stability toward selected targets. Binding free energy calculations and other essential dynamics analysis supports the finding. The selected lead compounds utilizing virtual screening and drug repurposing approach reported in this study are beneficial for medical scientists and experimental biologists in drug development for the treatment of human MPXV. Communicated by Ramaswamy H. Sarma
Traversable wormholes with double layer thin shells in quadratic gravity
Creators: name: Rosa, Joao Luís
name: André, Rui
name: Lemos, José P. S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In quadratic gravity, the junction conditions are six and permit the appearance of double layer thin shells. Double layers arise typically in theories with dipoles, i.e., two opposite charges, such as electromagnetic theories, and appear exceptionally in gravitational theories, which are theories with a single charge. We explore this property of the existence of double layers in quadratic gravity to find and study traversable wormholes in which the two domains of the wormhole interior region, where the throat is located, are matched to two vacuum domains of the exterior region via the use of two double layer thin shells. The quadratic gravity we use is essentially given by a $R+αR^2$ Lagrangian, where $R$ is the Ricci scalar of the spacetime and $α$ is a coupling constant, plus a matter Lagrangian. The null energy condition, or NEC for short, is tested for the whole wormhole spacetime. The analysis shows that the NEC is satisfied for the stress-energy tensor of the matter in the whole wormhole interior region, notably at the throat, and is satisfied for some of the stress-energy tensor components of the matter at the double layer thin shell, but is not satisfied for some other components, namely, the double layer stress-energy distribution component, at the thin shell. This seems to mean that the NEC is basically impossible, or at least very hard, to be satisfied when double layer thin shells are present. Single layer thin shells are also admitted within the theory, and we present thin shell traversable wormholes, i.e., wormholes without interior, with a single layer thin shell at the throat for which the corresponding stress-energy tensor satisfies the NEC, that are asymmetric, i.e., with two different vacuum domains of the exterior region joined at the wormhole throat.
description: 22 pages, 3 figures
Unconventional superfluidity of superconductivity on Penrose lattice
Creators: name: Liu, Yu-Bo
name: Shao, Zi-Yan
name: Cao, Ye
name: Yang, Fan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We theoretically investigate the gap function, superfluid density and the transition temperature of the superconductivity (SC) on semi-periodic Penrose lattice, where an attractive Hubbard model is adopted as an example. Firstly, we clarify that the gap function, density of states and superfluid density are all positively correlate to the extended degree of single particle states around the Fermi energy. Secondly, we identify that the paramagnetic component of the superfluid density does not decay to zero in the thermodynamic limit, which is completely different from the periodic system. The difference between the diamagnetic and paramagnetic currents keeps stable with whatever scaling, which is consistent with recent experimental results that although the superfluid density is lower than that of the periodic system, the system has bulk SC. Thirdly, we find that both the superfluid density and SC transition temperature can be boosted with the increase of disorder strength, which should be general to quasicrystal but unusual to periodic systems, reflecting the interplay between the underlying geometry and disorder.
description: 7 pages, 4 figures. version accepted by Sci. China-Phys. Mech. & Astron
In silico analysis of substitution mutations in the β-globin gene in Turkish population of β-thalassemia
Creators: name: Alkilani, Sima
name: Sevimoglu, Tuba
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Beta-thalassemia is a genetic blood disorder represented by anomalies in hemoglobin’s beta chain production. Most hemoglobin defects are a result of mutations of the structural β-globin gene. Many diseases, including β-thalassemia, benefit from computational studies that aid researchers in investigating the association of genotype and phenotype. In this study, the alanine substitution mutations of the β-globin protein sub-units in the Turkish population (Hb Ankara, Hb Siirt and Hb Izmir) and the effects of those mutations on the β-globin protein structure and performance are examined using molecular dynamics simulation. While Hb Ankara variant showed a non-conservative mutation, Hb Siirt and Hb Izmir showed a semi-conservative mutation. RMSF values of Hb Siirt, between residues 95 and 99, were higher than wild-type and the other mutant proteins. The residues of Hb Ankara showed lower fluctuation compared to the other structures. The mean ROG values were 1.47 nm, 1.46 nm, 1.49 nm and 1.48 and the average number of the hydrogen bonds were 92, 100, 99, and 89 for Hb Ankara, Hb Siirt and Hb Izmir, respectively. Moreover, a significant increase in overall motion in Hb Siirt was observed based on PCA analysis. Hb Siirt substitution mutation might cause an effect in β-globin proteins which could impact the protein function. This indicates a major role on beta globin subunit’s stability for alanine on 27th position. However, Hb Ankara and Hb Izmir variants may act as a silent mutation, since these two mutations did not show a large change in the dynamics of the protein. Communicated by Ramaswamy H. Sarma
Integrating out geometry: Holographic Wilsonian RG and the membrane paradigm
Creators: name: Faulkner, Thomas
name: Liu, Hong
name: Rangamani, Mukund
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We formulate a holographic Wilsonian renormalization group flow for strongly coupled systems with a gravity dual, motivated by the need to extract efficiently low energy behavior of such systems. Starting with field theories defined on a cut-off surface in a bulk spacetime, we propose that integrating out high energy modes in the field theory should correspond to integrating out a part of the bulk geometry. We describe how to carry out this procedure in practice in the classical gravity approximation using examples of scalar and vector fields. By integrating out bulk degrees of freedom all the way to a black hole horizon, this formulation defines a refined version of the black hole membrane paradigm. Furthermore, it also provides a derivation of the semi-holographic description of low energy physics.
description: 21 pages, 2 figures; references added, minor changes
Emotion Recognition for Challenged People Facial Appearance in Social using Neural Network
Creators: name: Deivendran, P.
name: Babu, P. Suresh
name: Malathi, G.
name: Anbazhagan, K.
name: Kumar, R. Senthil
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Human communication is the vocal and non verbal signal to communicate with others. Human expression is a significant biometric object in picture and record databases of surveillance systems. Face appreciation has a serious role in biometric methods and is good-looking for plentiful applications, including visual scrutiny and security. Facial expressions are a form of nonverbal communication; recognizing them helps improve the human machine interaction. This paper proposes an idea for face and enlightenment invariant credit of facial expressions by the images. In order on, the person's face can be computed. Face expression is used in CNN classifier to categorize the acquired picture into different emotion categories. It is a deep, feed-forward artificial neural network. Outcome surpasses human presentation and shows poses alternate performance. Varying lighting conditions can influence the fitting process and reduce recognition precision. Results illustrate that dependable facial appearance credited with changing lighting conditions for separating reasonable facial terminology display emotions is an efficient representation of clean and assorted moving expressions. This process can also manage the proportions of dissimilar basic affecting expressions of those mixed jointly to produce sensible emotional facial expressions. Our system contains a pre-defined data set, which was residential by a statistics scientist and includes all pure and varied expressions. On average, a data set has achieved 92.4% exact validation of the expressions synthesized by our technique. These facial expressions are compared through the pre-defined data-position inside our system. If it recognizes the person in an abnormal condition, an alert will be passed to the nearby hospital/doctor seeing that a message.
Electromagnetic Waves in Variable Media
Creators: name: Brosa, Ulrich
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences
subject: 78

description: Two methods are explained to exactly solve Maxwell's equations where permittivity, permeability and conductivity may vary in space. In the constitutive relations, retardation is regarded. If the material properties depend but on one coordinate, general solutions are derived. If the properties depend on two coordinates, geometrically restricted solutions are obtained. Applications to graded reflectors, especially to dielectric mirrors, to filters, polarizers and to waveguides, plain and cylindrical, are indicated. New foundations for the design of optical instruments, which are centered around an axis, and for the design of invisibility cloaks, plain and spherical, are proposed. The variability of material properties makes possible effects which cannot happen in constant media, e.g. stopping the flux of electromagnetic energy without loss. As a consequence, spherical devices can be constructed which bind electromagnetic waves.
In silico investigation of the structural stability as the origin of the pathogenicity of α-synuclein protofibrils
Creators: name: Yoon, Jeseong
name: Lee, MinJun
name: Park, Yunsu
name: Lee, Kyunghee
name: Shin, Seokmin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: α-Synuclein is a presynaptic neuronal protein. The fibril form of α-synuclein is a major constituent of the intraneuronal inclusion called Lewy body, a characteristic hallmark of Parkinson’s disease. Recent ssNMR and cryo-EM experiments of wild-type α-synuclein fibrils have shown polymorphism and observed two major polymorphs, rod and twister. To associate the cytotoxicity of α-synuclein fibrils with their structural features, it is essential to understand the origins of their structural stability. In this study, we performed molecular dynamics simulations of the two major polymorphs of wild-type α-synuclein fibrils. The predominance of specific fibril polymorphs was rationalized in terms of relative structural stability in aqueous environments, which was attributed to the cooperative contributions of various stabilizing features. The results of the simulations indicated that highly stable structures in aqueous environments could be maintained by the cooperation of compact sidechain packing in the hydrophobic core, backbone geometry of the maximal β-sheet content wrapping the hydrophobic core, and solvent-exposed sidechains with large fluctuations maximizing the solvation entropy. The paired structure of the two protofilaments provides additional stability, especially at the interface region, by forming steric zipper interactions and hiding the hydrophobic residues from exposure to water. The sidechain interaction analyses and pulling simulations showed that the rod polymorph has stronger sidechain interactions and exhibits higher dissociation energy than the twister polymorph. It is expected that our study will provide a basis for understanding the pathogenic behaviors of diverse amyloid strains in terms of their structural properties. Communicated by Ramaswamy H. Sarma
Применение проективных групп преобразования в инвариантных системах передачи информации
Creators: name: Павлов И. И.
name: Павлова М. С.
name: Гусельников И. А.
name: Тагаков С. С.
Publisher: name: Colloquium-journal
Year: 2019
Subjects: проективное преобразование
аффинное преобразование
сигнал
длина вектора
коэффициент.
projective transformation
affine transformation
the signal
vector length
coefficient.

description: Описание каналов связи группами преобразований, открывает теоретические возможности безыскаженной передачи сообщений за счет использования инвариантов соответствующей каналу группы. В статье рассмотрена схема проективного преобразования, которая сравнивается со схемой аффинного преобразования. Определяется аналитическое выражение для соотношений модулей входных и выходных сигналов для каналов, характеризуемых проективной схемой преобразований. Проективная группа преобразований описывает широкий класс нелинейных каналов с основным инвариантом в форме сложного от-ношения четырех точек.
description: The description of communication channels by transformation groups opens up theoretical possibilities of untraceable message transmission due to the use of invariants corresponding to the channel of the group. The article deals with the projective transformation scheme, which is compared with the affine transformation scheme. The analytical expression for the ratio of input and output signal modules for channels characterized by a projective transformation scheme is determined. The projective transformation group describes a wide class of nonlinear channels with a basic invariant in the form of a complex relation of four points.
Gliese 581g as a scaled-up version of Earth: atmospheric circulation simulations
Creators: name: Heng, Kevin
name: Vogt, Steven S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use three-dimensional simulations to study the atmospheric circulation on the first Earth-sized exoplanet discovered in the habitable zone of an M star. We treat Gliese 581g as a scaled-up version of Earth by considering increased values for the exoplanetary radius and surface gravity, while retaining terrestrial values for parameters which are unconstrained by current observations. We examine the long-term, global temperature and wind maps near the surface of the exoplanet --- the climate. The specific locations for habitability on Gliese 581g depend on whether the exoplanet is tidally-locked and how fast radiative cooling occurs on a global scale. Independent of whether the existence of Gliese 581g is confirmed, our study highlights the use of general circulation models to quantify the atmospheric circulation on potentially habitable, Earth-sized exoplanets, which will be the prime targets of exoplanet discovery and characterization campaigns in the next decade.
description: Accepted by MNRAS. 15 pages, 13 figures. Sample movies of simulations are available at http://www.phys.ethz.ch/~kheng/fms/
Structural, spectroscopic, molecular docking, ADME, molecular dynamics studies of Val-Trp dipeptide
Creators: name: Bicak, Bilge
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Hypertension is a significant risk factor for various diseases, especially heart, brain, and kidney diseases. It is known that many peptides have the property of lowering blood pressure and determine as ACE inhibitors. The purpose of this study is to obtain information about the molecular structure of Val-Trp (L-valyl-L-tryptophan), which is one of the antihypertensive peptides, by molecular mechanical, quantum mechanical, and spectroscopic methods (FT-IR and Raman). Also, it is aimed to investigate the interactions of Val-Trp dipeptide with receptors related to hypertension and to determine the pharmacokinetic profile due to the potential of the peptide to be a drug candidate. The peptide structure was optimized by DFT/B3LYP/6-311++G(d,p) basis set, then vibrational wavenumbers, molecular electrostatic potential (MEP), HOMO-LUMO (highest occupied molecular orbital- lowest unoccupied molecular orbital), NBO (natural bond orbital) analyzes were performed. The assignment of fundamental theoretical vibration wavenumbers was carried out with potential energy distribution analysis (PED). After the structural analyzes of the peptide were performed, the interactions of the peptide with Angiotensin-converting enzyme (ACE), Angiotensin II Receptor Type 1 (AT1R) and Renin were investigated by molecular docking study. Then, the molecular dynamic (MD) simulation of the peptide-ACE complex with the best binding affinity in the molecular docking studies was carried out for 50 ns. ADME (absorption, distribution, metabolism, and excretion) analysis of Val-Trp dipeptide was performed. In support of the studies carried out, enlightening information about the feasibility of the antihypertensive drug of Val-Trp dipeptide with the help of the ADME profile was presented to the literature. Communicated by Ramaswamy H. Sarma
Расчет соотношения между объемами токоподводящей жидкости и виноградных черенков при электростимуляции
Creators: name: Турчанин О. С.
name: Коваленко Ю. А.
name: Титаревский А. Л.
name: Щебетеев В. А.
name: Сбитнева Н. И.
Publisher: name: Colloquium-journal
Year: 2019
Subjects: черенки
виноград
электростимуляция
токоподводящая жидкость
cuttings
grapes
electrical stimulation
current-carrying fluid

description: В статье выводится формула для расчета оптимального соотношения объема электропроводящей жидкости (электролита), применяемой для подвода тока к черенкам винограда при стимуляции их роста, и объемом обрабатываемого материала с целью снижения затрат электроэнергии.
description: The article presents a formula for calculating the optimal ratio of the volume of an electrically conductive liquid (electrolyte) used to supply current to the grapes cuttings when stimulating their growth, and the volume of the material being processed in order to reduce electricity costs.
Synthesis, molecular docking and anticancer activity of 5,5'-(phenylmethylene)bis(6-amino-2-thiouracil) derivatives
Creators: name: Aremu, Oluwole Samuel
name: Alapour, Saba
name: Manhas, Neha
name: Singh, Moganavelli
name: Singh, Parvesh
name: Koorbanally, Neil Anthony
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: A series of 5,5′-(phenylmethylene)bis(6-amino-2-thiouracil) derivatives (1–13) were synthesized by the condensation of 6-amino-2-thiouracil and benzaldehyde derivatives under reflux in glacial acetic acid. Nine compounds (3, 5 and 7–13) were novel. Good binding affinity (BE) in the active site of Eg5 was shown by all compounds, which ranged between −5.0 kcal mol−1 to −26.7 kcal mol−1. Most compounds in the series exhibited a stronger interaction than 5-fluorouracil (BE = −8.0 kcal mol−1) with Eg5. The docking results were supported by cytotoxicity studies of the synthesized compounds against HeLa (cervical cancer) cell lines, where all compounds exhibited better anti-cancer activity than 5-fluorouracil (IC50 = 12.08 µg mL−1) at the lowest concentration (10 µg mL−1) with IC50 values ranging from 4.18 to 10.20 µg mL−1.
Perturbed breakup of gas bubbles in water: Memory, gas flow, and coalescence
Creators: name: Keim, Nathan C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The pinch-off of an air bubble from an underwater nozzle ends in a singularity with a remarkable sensitivity to a variety of perturbations. I report on experiments that break both the axial (i.e., vertical) and azimuthal symmetry of the singularity formation. The density of the inner gas influences the axial asymmetry of the neck near pinch-off. For denser gases, flow through the neck late in collapse changes the pinch-off dynamics. Gas density is also implicated in the formation of satellite bubbles. The azimuthal shape oscillations described by Schmidt et al., can be initiated by anisotropic boundary conditions in the liquid as well as with an asymmetric nozzle shape. I measure the n = 3 oscillatory mode, and observe the nonlinear, highly three-dimensional outcomes of pinch-off with large azimuthal perturbations. These are consistent with prior theory.