title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð° ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð°ÑÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð ÐµÐ½Ð¸Ñ-188
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Studying of the therapeutic potential of the radiopharmaceuticalbased on polymer carriers of Rhenium-188
Creators: name: ÐÐ¾ÑÑÐ¾Ð²Ð°Ð»Ð¾Ð²Ð°, ÐÐ»Ð¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
ÑÐ°Ð´Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ñ
ÑÐ°Ð´Ð¸Ð¾ÑÐ¸Ð½Ð¾Ð²ÑÐºÑÐ¾Ð¼Ð¸Ñ
Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸ÑÑ
ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ñ
ÑÐ¸Ð½Ð¾Ð²Ð¸Ñ
radiotherapy
radiosynovectomy
microparticles
radionuclides
arthritis

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð° Ð¸ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÑÐ¸Ð½ÑÐµÐ·Ð° Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹, Ñ Ð·Ð°Ð´Ð°Ð½Ð½ÑÐ¼Ð¸ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ°Ð¼Ð¸ Ð´Ð»Ñ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¸ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸ÑÂ 188Re, Ð² ÑÐµÐ»ÑÑ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð° Ðº Ð¼ÐµÑÑÑ Ð¸Ð½ÑÐµÑÐµÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÑÐµÐºÑÐ° Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ ÑÑÑÑÐ°Ð²Ð¾Ð² Ñ ÐºÑÑÑ Ð»Ð¸Ð½Ð¸Ð¸ Wistar. ÐÐ°Ð´Ð°ÑÐ¸, ÑÐµÑÐ°ÐµÐ¼ÑÐµ Ð² ÑÐ¾Ð´Ðµ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ°: 1) Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ ÑÐ¸Ð½ÑÐµÐ·Ð° Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÑ ÑÐ°ÑÑÐ¸Ñ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½ÑÐ¼ Ð²ÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð² Ð¸Ñ ÑÑÑÑÐºÑÑÑÑ ÑÐ°Ð´Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð°Â 188Re; 2) Ð¥Ð°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð²; 3) ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ ÑÂ 188Re Ð½Ð° ÑÐºÐ°Ð½Ð¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð° Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð² in vivo Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ; 4) Ð¡Ð¾Ð·Ð´Ð°Ð½Ð¸Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ ÐºÑÑÐ¿Ð½ÑÑ ÑÑÑÑÐ°Ð²Ð¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¸ ÐµÑ Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸Ñ Ð´Ð»Ñ ÑÐµÐ»ÐµÐ¹ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ; 5) ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÑÐµÐºÑÐ° ÑÐ°Ð·ÑÐ°Ð±Ð°ÑÑÐ²Ð°ÐµÐ¼Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°Â 188Re Ð½Ð° Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸. Ð Ð°Ð±Ð¾ÑÐ° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð ÐÐ¦Ð Ð¥Ð¢ Ð¸Ð¼. Ð. Ð. ÐÑÐ°Ð½Ð¾Ð²Ð° Ð¸ Ð¡ÐÐÐÐ£ Ð¸Ð¼. ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾, Ð³Ð´Ðµ Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾ÑÐ½Ð¾Ð²Ð½Ð°Ñ ÑÐ°ÑÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð²: ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾ÑÐ¾ÐºÐ¾Ð»Ð¾Ð² ÑÐ¸Ð½ÑÐµÐ·Ð° Ð¼Ð¸ÐºÑÐ¾Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð¸ Ð°Ð´ÑÐ¾ÑÐ±ÑÐ¸Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð¾Ð². ÐÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐ°Ð´Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¸ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¼Ñ ÑÑÑÐµÐºÑÑ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð¾Ð²Â Ð² in vivo ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ñ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ» ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÂ 188Re-ÐÐÐ-ÐÐ§, Ð² Ð²Ð¸Ð´Ðµ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹, Ð¼ÐµÑÐµÐ½Ð½ÑÑÂ 188Re, Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð° ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹, Ð¾ÑÐµÐ½ÐºÐ° ÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¸ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°, Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÑÐµÐºÑ Ð½Ð° ÑÐ¾Ð·Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹ ÐºÑÑÐ¿Ð½ÑÑ ÑÑÑÑÐ°Ð²Ð¾Ð².
description: This work is devoted to the development of a drug of complex composition and optimization of the technology of synthesis of polymer carriers, with specified characteristics for retention and directional action of 188Re, for the purpose of targeted delivery of radionuclide to the place of interest, as well as the study of the therapeutic effect of the drug on a model of inflammatory joint disease in Wistar rats. Tasks to be solved during the project: 1) Development of technologies for the synthesis of polymer particles with the sequential inclusion of the radioactive isotope 188Re in their structure; 2) Characterization of the obtained carriers using physico-chemical methods; 3) Study of the toxic effects of the developed carriers with 188Re on the tissues of the body of laboratory animals in in vivo studies; 4) Creation of a model of inflammatory joint disease using laboratory animals and adaptation for research purposes; 5) Study of the therapeutic effect of the developed drug 188Re on the model. The work was carried out on the basis of the N.N. A.M. Granov and St. Peter the Great, where most of the work was performed: the development of protocol for the synthesis of carriers, the adsorption of radioactive isotopes, animal experiments. As a result, the drug 188Re-PLA-MPs was developed in the form of polymer carriers labeled with 188Re, the carriers were characterized, the toxic effects and safety of using the drug were assessed, the therapeutic effect on the created model of inflammatory diseases of large joints was analyzed.