cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging
Creators: name: Wang, Yongjun
name: Zhang, Yuan
name: Srinivas, Ramishetti
name: Wang, Yuhua
name: Satterlee, Andrew
name: Huang, Leaf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Etoposide phosphate, a water-soluble anti-cancer prodrug, was successfully encapsulated together with indium in nanoparticles. We have used indium both as a carrier to deliver etoposide phosphate and as a SPECT imaging agent through incorporation of 111 In.
(400359) Margaret Craighead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Chemoenzymatic synthesis of heparan sulfate and heparin oligosaccharides and NMR analysis: Paving the way to a diverse library for glycobiologists
Creators: name: Linhardt, Robert J.
name: Liu, Jian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Heparin and heparan sulfate are sulfated carbohydrates that display a wide range of biological functions. A chemoenzymatic method is becoming a promising approach to synthesize heparin-like oligosaccharides with high efficiency.
The role of small and medium agrifood enterprises in rural transformation – The case of rice processors in Kenya
Creators: name: ​Ilie, Elena Teodora
name: Hickey, Amanda
name: Kelly, Siobhan
name: ​Ilie, Elena Teodora
name: Hickey, Amanda
name: Kelly, Siobhan
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: rural areas
subject: agrifood sector
subject: small and medium enterprises
subject: rice
subject: agrifood systems
subject: rural development
subject: logistics
subject: finance
subject: marketing techniques
subject: human resources
subject: partnerships
subject: Kenya

description: This study looks at the business models of small and medium-sized rice processors in Kenya in order to better understand the policy and technical support they need to grow and fulfill their role in agrifood systems transformation. More specifically, by employing semi-structured interviews with Kenyan rice millers, the technical study identifies challenges in their day-to-day business activities, including procurement, inbound and outbound logistics, in-house operations, financing, and human resources management. Additionally, the publication looks at opportunities for improving the business enabling environment in which these enterprises operate, providing a set of policy options to foster their role. The methodology cross fertilizes different disciplinary perspectives in order to gather evidence for formulating policy in a way that integrates several policy fields and cross-cutting issues such as food safety, quality and nutrition; farmer-market linkages; decent rural employment and gender equality; or rural investment. The paper showcases how small and medium agrifood manufacturers respond to the business-enabling environment and also contribute to local development from multiple angles.
description: FAO Document Repository: https://doi.org/10.4060/cb8953en
Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics
Creators: name: Bowers, Albert A.
name: Li, Bo
name: Walsh, Christopher T.
name: Wever, Walter J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Dithiolopyrrolone natural products have unique structures and exhibit a broad-spectrum of antimicrobial and anticancer activities. Isolated in the late 1940s, these molecules have attracted an increasing interest towards their biosynthesis, synthesis and mechanisms of action.
A Systematic Evaluation of Websites Offering Information on Chronic Kidney Disease
Creators: name: Bridgman, Jessica
name: Costello, Kaitlin
name: Jo, Minjeong
name: Song, Mi-Kyung
name: Lutz, Erin
name: Gilet, Constance
name: Hawley, Jennifer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In this study, we described the content and characteristics of 40 non-proprietary websites offering information about chronic kidney disease (CKD) and evaluated their information quality using the DISCERN scale and readability using Flesch Reading Ease and Flesch-Kincaid grade level. The areas in which the websites scored the lowest on the DISCERN scale were whether the website discussed knowledge gaps, presented balanced information, and was clear about the information source. Websites that rated higher quality on the DISCERN scale were more difficult to read. The quality and readability of many websites about CKD to be used as meaningful educational resources for patients who desire to learn more about CKD and treatment options remain inadequate.
METHODOLOGY FOR THE DEVELOPMENT OF DESIGN COMPETENCE IN STUDENTS THROUGH ENGINEERING PEDAGOGY.
Creators: name: Asrorova, Saodat
Publisher: name: Zenodo
Year: 2023

description: This article explores a comprehensive methodology for enhancing design competence in engineering students through effective pedagogical strategies. The study presents methods, results, and discussions of implementing this approach, concluding with suggestions for its successful integration into engineering education.
(400353) Elizabeth Dicksen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Tomographic reconstruction of quasistatic surface polariton fields
Creators: name: Hauer, Raphael
name: Haberfehlner, Georg
name: Kothleitner, Gerald
name: Kociak, Mathieu
name: Hohenester, Ulrich
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We theoretically investigate the tomographic reconstruction of the three-dimensional photonic environment of nanoparticles. As input for our reconstruction we use electron energy loss spectroscopy (EELS) maps for different rotation angles. We perform the tomographic reconstruction of surface polariton fields for smooth and rough nanorods, and compare the reconstructed and simulated photonic local density of states, which are shown to be in very good agreement. Using these results, we critically examine the potential of our tomography scheme, and discuss limitations and directions for future developments.
description: 13 pages, 9 figures
(400354) Jane [Meicklyohu] Dickson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Выращивание телок для роботизированной технологии доения
Creators: name: Филиппова О.Б.
name: Фролов А.И.
name: Бетин А.Н.
name: Хализова З.Н.
Publisher: name: Эффективное животноводство
Year: 2022
Subjects: молочное скотоводство
воспроизводство стада
продуктивность
dairy cattle breeding
herd reproduction
productivity

description: В условиях молочного комплекса проведен научно-производственный опыт на телках голштинской породы в возрасте от рождения до 6 месяцев. Животные опытной группы получали в составе рациона кормовые добавки. В результате их использования в 6-месячном возрасте превосходили животных контрольной группы по показателям продуктивности – на 4,2 % в валовом приросте живой массы и на 4,3 % в среднесуточном приросте.
description: In the conditions of the dairy complex, scientific and production experience was carried out on heifers of the Holstein breed aged from birth to 6 months. Animals of the experimental group received feed additives as part of the diet. As a result of their use at the age of 6 months, the animals of the control group were superior in terms of productivity – by 4.2% in gross weight gain and by 4.3% in average daily growth.
Supplementary Methods and Figures from Using museum specimens to track morphological shifts through climate change.
Creators: name: MacLean, Heidi J.
name: Nielsen, Matthew E.
name: Kingsolver, Joel G.
name: Buckley, Lauren B.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Museum specimens offer a largely untapped resource for detecting morphological shifts in response to climate change. However, morphological shifts can be obscured by shifts in phenology or distribution or sampling biases. Additionally, interpreting phenotypic shifts requires distinguishing whether they result from plastic or genetic changes. Previous studies using collections have documented consistent historical size changes, but the limited studies of other morphological traits have often failed to support, or even test, hypotheses. We explore the potential of collections by investigating shifts in the functionally significant coloration of a montane butterfly, Colias meadii, over the past 60 years within three North American geographical regions. We find declines in ventral wing melanism, which correspond to reduced absorption of solar radiation and thus reduced risk of overheating, in two regions. However, contrary to expected responses to climate warming, we find melanism increases in the most thoroughly sampled region. Relationships among temperature, phenology and morphology vary across years and complicate the distinction between plastic and genetic responses. Differences in these relationships may account for the differing morphological shifts among regions. Our findings highlight the promise of using museum specimens to test mechanistic hypotheses for shifts in functional traits, which is essential for deciphering interacting responses to climate change.This article is part of the theme issue ‘Biological collections for understanding biodiversity in the Anthropocene’.
Measure of noncompactness in the study of solutions for a system of integral equations
Creators: name: Karakaya, Vatan
name: Mursaleen, Mohammad
name: Bouzara, Nour El Houda
name: Sekman, Derya
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47H10, 47H08, 45G15

description: In this work, we prove the existence of solutions for a tripled system of integral equations using some new results of fixed point theory associated with measure of noncompactness. These results extend some previous works in the literature, since the condition under which the operator admits fixed points is more general than the others in literature.
description: 13 pages
Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation
Creators: name: Camilleri, M.
name: Becker, G.
name: Davies, A. N.
name: Mawe, G. M.
name: Drossman, D. A.
name: Webster, L. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Opioids are effective for acute and chronic pain conditions, but their use is associated with often difficult-to-manage constipation and other gastrointestinal (GI) effects due to effects on peripheral μ-opioid receptors in the gut. The mechanism of opioid-induced constipation (OIC) differs from that of functional constipation (FC), and OIC may not respond as well to most first-line treatments for FC. The impact of OIC on quality of life (QoL) induces some patients to decrease or stop their opioid therapy to relieve or avoid constipation.
Supplementary Methods and Figures from Using museum specimens to track morphological shifts through climate change
Creators: name: MacLean, Heidi J.
name: Nielsen, Matthew E.
name: Kingsolver, Joel G.
name: Buckley, Lauren B.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Museum specimens offer a largely untapped resource for detecting morphological shifts in response to climate change. However, morphological shifts can be obscured by shifts in phenology or distribution or sampling biases. Additionally, interpreting phenotypic shifts requires distinguishing whether they result from plastic or genetic changes. Previous studies using collections have documented consistent historical size changes, but the limited studies of other morphological traits have often failed to support, or even test, hypotheses. We explore the potential of collections by investigating shifts in the functionally significant coloration of a montane butterfly, Colias meadii, over the past 60 years within three North American geographical regions. We find declines in ventral wing melanism, which correspond to reduced absorption of solar radiation and thus reduced the risk of overheating, in two regions. However, contrary to expected responses to climate warming, we find melanism increases in the most thoroughly sampled region. Relationships among temperature, phenology and morphology vary across years and complicate the distinction between plastic and genetic responses. Differences in these relationships may account for the differing morphological shifts among regions. Our findings highlight the promise of using museum specimens to test mechanistic hypotheses for shifts in functional traits, which is essential for deciphering interacting responses to climate change.This article is part of the theme issue ‘Biological collections for understanding biodiversity in the Anthropocene’.
Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI-IBS)
Creators: name: Kanazawa, M.
name: Whitehead, W. E.
name: Palsson, O. S.
name: Gangarosa, L. M.
name: Fukudo, S.
name: van Tilburg, M. A. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Acute intestinal infection leads to persistent intestinal smooth muscle hypercontractility and pain hypersensitivity after resolution of the infection in animal models. We investigated whether post-infectious irritable bowel syndrome (PI-IBS) is associated with abnormalities in phasic contractions of the colon, smooth muscle tone and pain sensitivity compared to non-PI-IBS (NI-IBS) or healthy controls (HC).
Electronic Supplementary Material from Mechanism of memory effect of paste which dominates desiccation crack patterns.
Creators: name: Nakahara, Akio
name: Hiraoka, Tomoki
name: Rokuya Hayashi
name: Matsuo, Yousuke
name: Kitsunezaki, So
Publisher: name: The Royal Society
Year: 2018
Subjects: Mechanics

description: Directions of primary and additional shakes in memory-rewriting experiments and resultant desiccation crack patterns.
ANMS-ESNM position paper and consensus guidelines on biofeedback therapy for anorectal disorders
Creators: name: Whitehead, W. E.
name: Bharucha, A. E.
name: Rao, S. S. C.
name: Di Lorenzo, C.
name: Benninga, M. A.
name: Chiarioni, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Anorectal disorders such as dyssynergic defecation, fecal incontinence, levator ani syndrome and solitary rectal ulcer syndrome are common, and affect both the adult and pediatric populations. Although they are treated with several treatment approaches, over the last two decades, biofeedback therapy using visual and verbal feedback techniques has emerged as an useful option. Because it is safe, it is commonly recommended. However, the clinical efficacy of biofeedback therapy in adults and children is not clearly known, and there is a lack of critical appraisal of the techniques used and the outcomes of biofeedback therapy for these disorders. The American Neurogastroenterology and Motility Society and the European Society of Neurogastroenterology and Motility convened a task force to examine the indications, study performance characteristics, methodologies used and the efficacy of biofeedback therapy, and to provide evidence-based recommendations. Based on the strength of evidence, biofeedback therapy is recommended for the short term and long term treatment of constipation with dyssynergic defecation (Level I, Grade A), and for the treatment of fecal incontinence (Level II, Grade B). Biofeedback therapy may be useful in the short-term treatment of Levator Ani Syndrome with dyssynergic defecation (Level II, Grade B), and solitary rectal ulcer syndrome with dyssynergic defecation (Level III, Grade C), but the evidence is fair. Evidence does not support the use of biofeedback for the treatment of childhood constipation (Level 1, Grade D).
(400355) James Deuchars
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Short proofs, generalizations and applications of certain identities concerning multiple Dirichlet series
Creators: name: Tóth, László
Publisher: name: arXiv
Year: 2022
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11A05, 11A25, 11N37

description: We present other proofs, generalizations and analogues of the identities concerning multiple Dirichlet series by Tahmi and Derbal (2022). As applications, we obtain asymptotic formulas with remainder terms for certain related sums.
description: 14 pages, revised
Baryon chemical potential and in-medium properties of BPS skyrmions
Creators: name: Adam, C.
name: Klähn, T.
name: Naya, C.
name: Sanchez-Guillen, J.
name: Vazquez, R.
name: Wereszczynski, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We continue the investigation of thermodynamical properties of the BPS Skyrme model. In particular, we analytically compute the baryon chemical potential both in the full field theory and in a mean-field approximation. In the full field theory case, we find that the baryon chemical potential is always exactly proportional to the baryon density, for arbitrary solutions. We further find that, in the mean-field approximation, the BPS Skyrme model approaches the Walecka model in the limit of high density - their thermodynamical functions as well as the equation of state agree in this limit. This fact allows to read off some properties of the $ω$-meson from the BPS Skyrme action, even though the latter model is entirely based on the (pionic) $SU(2)$ Skyrme field. On the other hand, at low densities, at the order of the usual nuclear matter density, the equations of state of the two models are no longer universal, such that a comparison depends on some model details. Still, also the BPS Skyrme model gives rise to nuclear saturation in this regime, leading, in fact, to an exact balance between repulsive and attractive forces. The perfect fluid aspects of the BPS Skyrme model, which, together with its BPS properties, form the base of our results, are shown to be in close formal analogy with the Eulerian formulation of relativistic fluid dynamics. Within this analogy, the BPS Skyrme model, in general, corresponds to a non-barotropic perfect fluid.
description: Latex, 28 pages, 3 figures
Thermodynamics and evaporation of a modified Schwarzschild black hole in a non--commutative gauge theory
Creators: name: Filho, A. A. Araújo
name: Zare, S.
name: Porfírio, P. J.
name: Kříž, J.
name: Hassanabadi, H.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this work, we study the thermodynamic properties on a non--commutative background via gravitational gauge field potentials. This procedure is accomplished after contracting de Sitter (dS) group, $\mathrm{SO}(4,1)$, with the Poincarè group, $\mathrm{ISO}(3,1)$. Particularly, we focus on a static spherically symmetric black hole. In this manner, we calculate the modified Hawking temperature and the other deformed thermal state quantities, namely, entropy, heat capacity, Helmholtz free energy and pressure. Finally, we also investigate the black hole evaporation process in such a context.
description: 14 pages
(400356) David Deuchars
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Electronic Supplementary Material from Mechanism of memory effect of paste which dominates desiccation crack patterns
Creators: name: Nakahara, Akio
name: Hiraoka, Tomoki
name: Rokuya Hayashi
name: Matsuo, Yousuke
name: Kitsunezaki, So
Publisher: name: The Royal Society
Year: 2018
Subjects: Mechanics

description: Directions of primary and additional shakes in memory-rewriting experiments and resultant desiccation crack patterns.
Экдистерон содержащие субстанции для кормовых добавок с улучшенными качествами
Creators: name: Тимофеев Н.П.
Publisher: name: Эффективное животноводство
Year: 2022
Subjects: кормовые добавки
фитоэкдистероиды
анаболические субстанции
20-гидроксиэкдизон
левзея сафлоровидная
серпуха венценосная
feed additives
phytoecdysteroids
anabolic substances
20-hydroxyecdysone
Rhaponticum carthamoides
Serratula coronata

description: В статье рассмотрены и предложены перспективные компоненты для производства фитогенных кормовых добавок с улучшенными качествами на основе экдистероидов и главного их биоактивного компонента экдистерона (20-гидроксиэкдизона). Показано, что экдистерон содержащие фитобиотики являются альтернативными субстанциями в сравнении с запрещенными кормовыми антибиотиками, синтетическими стимуляторами гормонального действия и антистрессовыми транквилизаторами. При этом они имеют прямой анаболический и антистрессовый эффект, экономически выгодны для производителя продукции, не имеют проблем с безопасностью и токсичностью и сочетаю тся с другими традиционными средствами. Растения, которые заслуживают внимания для масштабного производства высокоэффективных, общедоступных субстанций с экдистероном в достаточных количествах и по разумной цене из флоры России – это левзея сафлоровидная Rhaponticum carthamoides и серпуха венценосная Serratula coronata.
description: The article considers and proposes promising components for the production of phytogenic feed additives with improved qualities based on ecdysteroids and the main bioactive component ecdysterone (20-hydroxyecdysone). It was shown that ecdisterone-containing phytobiotics are alternative substances compared to prohibited synthetic hormonal stimulants and anti-stress tranquilizers. At the same time, they have a direct anabolic and anti-stress effect, are economically profitable for the product manufacturer, have no safety and toxicity problems and are combined with other traditional means. Plants that deserve attention for the large-scale production of highly effective, commonly available substances with ecdysterone in sufficient quantities and at a reasonable price from the flora of Russia are Rhaponticum carthamoides and Serratula coronata.
Globalization of Twisted partial Hopf actions
Creators: name: Alves, Marcelo M. S.
name: Batista, Eliezer
name: Dokuchaev, Michael
name: Paques, Antonio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 16T05, 16S40

description: In this work, we review some properties of twisted partial actions of Hopf algebras on unital algebras and give necessary and sufficient conditions for a twisted partial action to have a globalization. We also elaborate a series of examples.
description: 31 pages
Инфекционная анемия цыплят – современное представление о болезни
Creators: name: Джавадов Э.Д.
name: Веретенников В.В.
name: Тарлавин Н.В.
name: Красков Д.А.
Publisher: name: Эффективное животноводство
Year: 2022
Subjects: птицеводство
инфекционная анемия цыплят
птица
вирус
Poultry farming
infectious anemia of chickens
poultry
virus

description: Современное Российское птицеводство является наиболее значимым в агропромышленном комплексе по своей окупаемости и получении прибыли. Для того, чтобы поддерживать эти параметры на должном уровне необходимы глубокие знания ветеринарных специалистов в области инфекционных заболеваний, особенно иммунодепрессивных.
description: Modern Russian poultry farming is the most significant in the agro-industrial complex in terms of its payback and profit. In order to maintain these parameters at the proper level, in-depth knowledge of veterinary specialists in the field of infectious diseases, especially immunosuppressive ones, is necessary.
(400352) James Dicksen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary tables and figures from Facets of phylodiversity: evolutionary diversification, divergence and survival as conservation targets.
Creators: name: Kling, Matthew M.
name: Mishler, Brent D.
name: Thornhill, Andrew H.
name: Baldwin, Bruce G.
name: Ackerly, David D.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Science

description: Biodiversity is often described as having multiple facets, including species richness, functional diversity and phylogenetic diversity. In this paper, we argue that phylogenetic diversity itself has three distinct facets—lineage diversification, character divergence and survival time—that can be quantified using distinct branch length metrics on an evolutionary tree. Each dimension is related to different processes of macroevolution, has different spatial patterns and is tied to distinct goals for conserving biodiversity and protecting its future resilience and evolutionary potential. We compared the landscapes identified as top conservation priorities by each of these three metrics in a conservation gap analysis for California, a world biodiversity hotspot, using herbarium data on the biogeography and evolutionary relationships of more than 5000 native plant species. Our analysis incorporated a novel continuous metric of current land protection status, fine-scale data on landscape intactness and an optimization algorithm used to identify complementary priority sites containing concentrations of taxa that are evolutionarily unique, vulnerable due to small range size and/or poorly protected across their ranges. Top conservation priorities included pockets of coastal and northern California that ranked highly for all three phylodiversity dimensions and for species richness, as well as sites uniquely identified by each metric whose value may depend on whether properties such as genetic divergence, high net diversification or independent survival experience are most desirable in an Anthropocene flora.
Evolution of column density distributions within Orion~A
Creators: name: Stutz, A. M.
name: Kainulainen, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We compare the structure of star-forming molecular clouds in different regions of Orion A to determine how the column density probability distribution function (N-PDF) varies with environmental conditions such as the fraction of young protostars. A correlation between the N-PDF slope and Class 0 protostar fraction has been previously observed in a low-mass star-formation region (Perseus) by Sadavoy; here we test if a similar correlation is observed in a high-mass star-forming region. We use Herschel data to derive a column density map of Orion A. We use the Herschel Orion Protostar Survey catalog for accurate identification and classification of the Orion A young stellar object (YSO) content, including the short-lived Class 0 protostars (with a $\sim$ 0.14 Myr lifetime). We divide Orion A into eight independent 13.5 pc$^2$ regions; in each region we fit the N-PDF distribution with a power-law, and we measure the fraction of Class 0 protostars. We use a maximum likelihood method to measure the N-PDF power-law index without binning. We find that the Class 0 fraction is higher in regions with flatter column density distributions. We test the effects of incompleteness, YSO misclassification, resolution, and pixel-scale. We show that these effects cannot account for the observed trend. Our observations demonstrate an association between the slope of the power-law N-PDF and the Class 0 fractions within Orion A. Various interpretations are discussed including timescales based on the Class 0 protostar fraction assuming a constant star-formation rate. The observed relation suggests that the N-PDF can be related to an "evolutionary state" of the gas. If universal, such a relation permits an evaluation of the evolutionary state from the N-PDF power-law index at much greater distances than those accesible with protostar counts. (abridged)
description: A&A Letter, accepted
Restriction of Uniform Crossnorms
Creators: name: Kubrusly, Carlos S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47A80, 46M05

description: Consider the space $B[X\otimes_αY]$ of operators on the tensors product ${X\otimes_αY}$ of normed spaces $X$ and $Y$ equipped with a uniform crossnorm ${\|\cdot\|_α}$$.$ Take the induced uniform norm on $B[X\otimes_αY]$ and consider its restriction to the tensor product ${B[X]\otimes B[Y]}$ of the algebra of operators $B[X]$ and $B[Y].$ It is proved that such a restriction is a reasonable crossnorm on ${B[X]\otimes B[Y]}$.
Development and pilot testing of an integrated, web-based self-management program for irritable bowel syndrome (IBS)
Creators: name: Weinberger, M.
name: Fowler, B.
name: Palsson, O. S.
name: Dorn, S. D.
name: McCoy, R.
name: Drossman, D. A.
name: Woldeghebriel, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Although essential, many medical practices are unable to adequately support irritable bowel syndrome (IBS) patient self-management. Web-based programs can help overcome these barriers.
Minocycline treatment for HIV-associated cognitive impairment: Results from a randomized trial
Creators: name: Jarocki, B.
name: Hosey, L.
name: Singer, E.
name: Smith, E.
name: Sacktor, N.
name: Paul, R.
name: Nath, A.
name: Robertson, K.
name: Ellis, R. J.
name: Deng, L.
name: Clifford, D. B.
name: Schifitto, G.
name: Evans, S.
name: Scarsi, K.
name: Weihe, J.
name: McCarthy, S.
name: Cohen, B. A.
name: Miyahara, S.
name: Zink, M. C.
name: Coombs, R. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: OBJECTIVE: We conducted a study of minocycline to assess its safety, tolerability, and efficacy for the treatment of HIV-associated cognitive impairment.

METHODS: HIV-1-infected individuals with progressive neurocognitive decline were enrolled in a double-blind, placebo-controlled study of minocycline. Participants were randomized to receive minocycline 100 mg or matching placebo orally every 12 hours. The primary efficacy measure was change in a neuropsychological test composite z score (NPZ-8) from baseline to week 24. Measures of safety included the frequency of adverse events and changes over time in laboratory tests. After 50% of participants completed the double-blind phase, an interim analysis of futility for the primary outcome measure was performed, and our Data and Safety Monitoring Board recommended early study termination.

RESULTS: A total of 107 HIV-1-infected individuals with cognitive impairment were enrolled. The minocycline group did not show improvement in the primary outcome measure (NPZ-8) (mean 24-week change = 0.12) compared to placebo (mean 24-week change = 0.17) (95% confidence interval = [-0.26, 0.39], p = 0.70). There were few severe adverse events or laboratory abnormalities in either treatment group.

CONCLUSION: Minocycline was safe and well-tolerated in individuals with HIV-associated cognitive impairment, but cognitive improvement was not observed. Classification of evidence. This interventional study provides Class II evidence for the safety, tolerability, and efficacy of minocycline for the treatment of HIV-associated cognitive impairment.
Symmetry protected skyrmions in 3D spin-orbit coupled Bose gases
Creators: name: Chen, Guanjun
name: Li, Tiantian
name: Zhang, Yunbo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We present a variational study of pseudo-spin $1/2$ Bose gases in a harmonic trap with weak 3D spin-orbit coupling of $\bmsigma\cdot\mathbf{p}$ type. This spin-orbit coupling mixes states with different parities, which inspires us to approximate the single particle state with the eigenstates of the total angular momentum, i.e. superposition of harmonic $s$-wave and $p$-wave states. As the time reversal symmetry is protected by two-body interaction, we set the variational order parameter as the combination of two mutually time reversal symmetric eigenstates of the total angular momentum. The variational results essentially reproduce the 3D skyrmion-like ground state recently identified by Kawakami {\it et al.}. We show that these skyrmion-like ground states emerging in this model are primarily caused by $p$ wave spatial mode involving in the variational order parameter that drives two spin components spatially separated. We find the ground state of this system falls into two phases with different density distribution symmetries depending on the relative magnitude of intraspecies and interspecies interaction: Phase I has parity symmetric and axisymmetric density distributions, while Phase II is featured with special joint symmetries of discrete rotational and time reversal symmetry. With the increasing interaction strength the transition occurs between two phases with distinct density distributions, while the topological 3D skyrmion-like spin texture is symmetry protected.
description: 7.1 pages, 3 figures
Mathematical analysis of an in-host model of viral dynamics with spatial heterogeneity
Creators: name: Pankavich, Stephen
name: Parkinson, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35K51, 92C17, 35Q92, 35K45, 35K57, 92C50, 35B40

description: We consider a spatially-heterogeneous generalization of a well-established model for the dynamics of the Human Immunodeficiency Virus-type 1 (HIV) within a susceptible host. The model consists of a nonlinear system of three coupled reaction-diffusion equations with parameters that may vary spatially. Upon formulating the model, we prove that it preserves the positivity of initial data and construct global-in-time solutions that are both bounded and smooth. Finally, additional results concerning the local and global asymptotic behavior of these solutions are also provided.
description: 21 pages
Star Formation and Relaxation in 379 Nearby Galaxy Clusters
Creators: name: Cohen, Seth A.
name: Hickox, Ryan C.
name: Wegner, Gary A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the relationship between star formation (SF) and level of relaxation in a sample of 379 galaxy clusters at z < 0.2. We use data from the Sloan Digital Sky Survey to measure cluster membership and level of relaxation, and to select star-forming galaxies based on mid-infrared emission detected with the Wide-Field Infrared Survey Explorer. For galaxies with absolute magnitudes M_r < -19.5, we find an inverse correlation between SF fraction and cluster relaxation: as a cluster becomes less relaxed, its SF fraction increases. Furthermore, in general, the subtracted SF fraction in all unrelaxed clusters (0.117 +/- 0.003) is higher than that in all relaxed clusters (0.097 +/- 0.005). We verify the validity of our SF calculation methods and membership criteria through analysis of previous work. Our results agree with previous findings that a weak correlation exists between cluster SF and dynamical state, possibly because unrelaxed clusters are less evolved relative to relaxed clusters.
description: 6 pages, 4 figures, accepted for publication in ApJ
(400349) Robert Dickson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
FADO: Floorplan-Aware Directive Optimization for High-Level Synthesis Designs on Multi-Die FPGAs
Creators: name: Du, Linfeng
name: Liang, Tingyuan
name: Sinha, Sharad
name: Xie, Zhiyao
name: Zhang, Wei
Publisher: name: arXiv
Year: 2022
Subjects: subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: Multi-die FPGAs are widely adopted to deploy large hardware accelerators. Two factors impede the performance optimization of HLS designs implemented on multi-die FPGAs. On the one hand, the long net delay due to nets crossing die-boundaries results in an NP-hard problem to properly floorplan and pipeline an application. On the other hand, traditional automated searching flow for HLS directive optimizations targets single-die FPGAs, and hence, it cannot consider the resource constraints on each die and the timing issue incurred by the die-crossings. Further, it leads to an excessively long runtime to legalize the floorplan of HLS designs generated under each group of configurations during directive optimization due to the large design scale. To co-optimize the directives and floorplan of HLS designs on multi-die FPGAs, we propose the FADO framework, which formulates the directive-floorplan co-search problem based on the multi-choice multi-dimensional bin-packing and solves it using an iterative optimization flow. For each step of directive search, a latency-bottleneck-guided greedy algorithm searches for more efficient directive configurations. For floorplanning, instead of repetitively incurring global floorplanning algorithms, we implement a more efficient incremental floorplan legalization algorithm. It mainly applies the worst-fit online bin-packing algorithm to balance the floorplan, together with an offline best-fit-decreasing re-packing to compact the floorplan, followed by pipelining of long wires crossing die-boundaries. Through experiments on HLS designs mixing dataflow and non-dataflow kernels, FADO not only well-automates the co-optimization and finishes within 693X~4925X shorter runtime, compared with DSE assisted by global floorplanning, but also yields an improvement of 1.16X~8.78X in overall workflow execution time after implementation on the Xilinx Alveo U250 FPGA.
description: Accepted as a conference paper at FPGA '23. Open source at: https://github.com/RipperJ/FADO
Supplementary tables and figures from Facets of phylodiversity: evolutionary diversification, divergence and survival as conservation targets
Creators: name: Kling, Matthew M.
name: Mishler, Brent D.
name: Thornhill, Andrew H.
name: Baldwin, Bruce G.
name: Ackerly, David D.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Science

description: Biodiversity is often described as having multiple facets, including species richness, functional diversity and phylogenetic diversity. In this paper, we argue that phylogenetic diversity itself has three distinct facets—lineage diversification, character divergence and survival time—that can be quantified using distinct branch length metrics on an evolutionary tree. Each dimension is related to different processes of macroevolution, has different spatial patterns and is tied to distinct goals for conserving biodiversity and protecting its future resilience and evolutionary potential. We compared the landscapes identified as top conservation priorities by each of these three metrics in a conservation gap analysis for California, a world biodiversity hotspot, using herbarium data on the biogeography and evolutionary relationships of more than 5000 native plant species. Our analysis incorporated a novel continuous metric of current land protection status, fine-scale data on landscape intactness and an optimization algorithm used to identify complementary priority sites containing concentrations of taxa that are evolutionarily unique, vulnerable due to small range size and/or poorly protected across their ranges. Top conservation priorities included pockets of coastal and northern California that ranked highly for all three phylodiversity dimensions and for species richness, as well as sites uniquely identified by each metric whose value may depend on whether properties such as genetic divergence, high net diversification or independent survival experience are most desirable in an anthropocene flora.
Olfactory copy number association with age at onset of Alzheimer disease
Creators: name: Lupski, J. R.
name: Li, Y.
name: Zaidi, S. N.Y.
name: Chasse, S.
name: Belmont, J. W.
name: Jin, W.
name: Wilhelmsen, K.
name: Dawson, B.
name: Szigeti, K.
name: Doody, R. S.
name: Shaw, C. A.
name: Wiszniewska, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: OBJECTIVES: Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability for occurrence and age at onset (AAO). We performed a cases-only genome-wide CNV association study for age at onset of AD.

METHODS: The discovery case series (n = 40 subjects with AD) was evaluated using array comparative genome hybridization (aCGH). A replication case series (n = 507 subjects with AD) was evaluated using Affymetrix array (n = 243) and multiplex ligation-dependent probe amplification (n = 264). Hazard models related onset age to CNV.

RESULTS: The discovery sample identified a chromosomal segment on 14q11.2 (19.3-19.5 Mb, NCBI build 36, UCSC hg18 March 2006) as a region of interest (genome-wide adjusted p = 0.032) for association with AAO of AD. This region encompasses a cluster of olfactory receptors. The replication sample confirmed the association (p = 0.035). The association was found for each APOE4 gene dosage (0, 1, and 2).

CONCLUSION: High copy number in the olfactory receptor region on 14q11.2 is associated with younger age at onset of AD.