cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation of the impact of two C5 genetic variants on C5-eculizumab complex stability at the molecular level
Creators: name: Peixoto, Vanda P.
name: Prudêncio, Cristina
name: Vieira, Mónica
name: Sousa, Sérgio F.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Complement C5 is the target of the monoclonal antibody eculizumab, used in complement dysregulating disorders, like the rare disease Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is an acquired hematopoietic stem cell condition characterized by aberrant destruction of erythrocytes, chronic hemolytic anemia, and thromboembolism propensity. C5 is a protein component of the complement system which is part of the immune system of the body and plays a prominent role in the destruction of red blood cells, misidentifying them as a threat. This work describes the application of molecular dynamics simulations to the study of the underlying interactions between complement C5 and eculizumab. This study also reveals the importance of single nucleotide polymorphisms on C5 protein concerning the effective inhibition of the mAB, involving the mechanistic events taking place at the interface spots of the complex. The predicted conformational change in the C5 Arg885/His/Cys mutation has implications on the protein’s interaction with eculizumab, compromising their compatibility. The acquired insights into the conformational changes, dynamics, flexibility, and interactions shed light on the knowledge of the function of this biomolecule providing answers about the poor response to the treatment in PNH patient carriers of the mutations. By investigating the intricate dynamics, significant connections between C5 and eculizumab can be uncovered. Such insights may aid in the creation of novel compounds or lead to the enhancement of eculizumab’s efficacy.
title: ÐÐµÐ¾Ð´ÐµÐ·Ð¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´ÐµÐ½Ð¸Ðµ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° 20-ÑÑÐ°Ð¶Ð½Ð¾Ð³Ð¾ Ð¶Ð¸Ð»Ð¾Ð³Ð¾ Ð´Ð¾Ð¼Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾ÑÑÐºÐ¾Ð²Ð°, ÐÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð³ÐµÐ¾Ð´ÐµÐ·Ð¸ÑÐµÑÐºÐ¸Ð¹ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ
Ð¶Ð¸Ð»Ð¾Ð¹ Ð´Ð¾Ð¼
Ð¼Ð½Ð¾Ð³Ð¾ÑÑÐ°Ð¶Ð½ÑÐµ Ð·Ð´Ð°Ð½Ð¸Ñ
Ð³ÐµÐ¾Ð´ÐµÐ·Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð¼Ð¾Ð½Ð¸ÑÐ¾ÑÐ¸Ð½Ð³ Ð·Ð´Ð°Ð½Ð¸Ð¹
Ð²ÑÑÐ¾ÐºÐ¾ÑÐ¾ÑÐ½ÑÐµ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ

description: ÐÑÐ¸ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ðµ Ð²Ð¾Ð·Ð½Ð¸ÐºÐ°ÐµÑ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð°Ñ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð° - ÐºÐ°ÑÐµÑÑÐ²Ð¾ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ°Ð±Ð¾Ñ. ÐÐ»Ñ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÑ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸ÑÐ¼ Ðº Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ñ, ÑÐ¾Ð±Ð»ÑÐ´Ð°ÑÑ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½ÑÐµ ÑÑÐ°Ð½Ð´Ð°ÑÑÑ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð² ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ðµ, Ð´Ð¾ÐºÑÐ¼ÐµÐ½ÑÑ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð½Ð°Ð´Ð·Ð¾ÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð²ÐµÐ´Ð¾Ð¼ÑÑÐ²ÐµÐ½Ð½ÑÐµ Ð½Ð¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½ÑÐµ Ð´Ð¾ÐºÑÐ¼ÐµÐ½ÑÑ.
ÐÐµÐ¾Ð´ÐµÐ·Ð¸ÑÐµÑÐºÐ¸Ð¹ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ°Ð±Ð¾Ñ Ð¸Ð³ÑÐ°ÐµÑ Ð²Ð°Ð¶Ð½ÑÑ ÑÐ¾Ð»Ñ Ð¿ÑÐ¸ ÑÐµÑÐµÐ½Ð¸Ð¸ ÑÑÐ¸Ñ Ð·Ð°Ð´Ð°Ñ. Ð¡Ð²Ð¾ÐµÐ²ÑÐµÐ¼ÐµÐ½Ð½Ð°Ñ Ð¸ Ð²ÑÑÐ¾ÐºÐ¾ÑÐ¾ÑÐ½Ð°Ñ Ð³ÐµÐ¾Ð´ÐµÐ·Ð¸ÑÐµÑÐºÐ°Ñ ÑÐºÑÐ¿ÐµÑÑÐ½Ð°Ñ Ð¾ÑÐµÐ½ÐºÐ°, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸ÑÑÑ Ð²Ð¾ Ð²ÑÐµÐ¼Ñ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ°Ð±Ð¾Ñ Ð¸ Ð´Ð»Ñ ÐºÐ¾ÑÐ¾ÑÐ¾Ð¹ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÑÑÑÑ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐµ ÑÐ¿ÑÑÐ½Ð¸ÐºÐ¾Ð²ÑÐµ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð½Ð° ÑÐ°Ð½Ð½Ð¸Ñ ÑÑÐ°Ð¿Ð°Ñ ÑÐ·Ð½Ð°ÑÑ Ð¾Ð± Ð¾ÑÐºÐ»Ð¾Ð½ÐµÐ½Ð¸ÑÑ Ð¾Ñ Ð·Ð°Ð´Ð°Ð½Ð½ÑÑ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð².
ПОСТАНОВКА РУК АРФИСТА КАК ПРОЦЕСС ЗВУКОИЗВЛЕЧЕНИЯ
Creators: name: ПОКРОВСКАЯ НАДЕЖДА НИКОЛАЕВНА
Publisher: name: Вестник музыкальной науки
Year: 2019
Subjects: АРФА
А. И. СЛЕПУШКИН
РУССКАЯ АРФОВАЯ ШКОЛА
МЕТОДИКА ОБУЧЕНИЯ
МЕТОДИЧЕСКИЕ ИЗДАНИЯ
ЗВУКОИЗВЛЕЧЕНИЕ
HARP
A. I. SLEPUSHKIN
RUSSIAN HARP SCHOOL
TEACHING METHODS
METHODICAL PUBLICATIONS
SOUND PRODUCTION

description: Статья посвящена вопросам методики обучения игре на арфе. Это вызвано не только крайней скудостью методической базы инструмента, в которой насчитывается лишь около 10 работ по методике, изданных на русском языке. В работах Н. Г. Парфёнова (1927), М. П. Мчеделова (1960 и 1973), К. А. Эрдели (1967), М. А. Рубина (1973), В. Г. Дуловой (1975), К. К. Сараджева (2001), Н. Н. Покровской (2012) освещены особенности русской арфовой школы, созданной по методу А.И. Слепушкина в начале XX в. Из них только публикации Парфёнова, Рубина и Покровской чисто методические. В трудах других авторов наряду с историей инструмента, общемузыкальными вопросами и мемуарами уделено место и методике. Автора статьи насторожила противоречивость в трактовке некоторыми ведущими педагогами-арфистами основных положений постановочных принципов русской арфовой школы, впервые в 1927 г. ясно изложенных в публикации ученика великого русского арфиста Н. Г. Парфёнова «Техника игры на арфе. Метод проф. А. И. Слепушкина». Эта противоречивость заметно проступила уже в редакции М. П. Мчеделова, выпущенной им «Школы...» под именем Н. Г. Парфёнова и 1960 и в 1973 гг. Кроме того, ключевые сегменты обучения, связанные с пониманием термина «постановка в широком смысле слова», с движениями в цепочке «плечо рука предплечье локоть запястье -кисть палец» в переходные моменты игры, остаются до сих пор не разработанными. Это также вопросы о возникновении напряжения в разных частях игрового аппарата учащихся, предупреждения и исправления постановочных ошибок и др. В пределах одной статьи проблемы, названные в ней, не решить. Поэтому задачами автора статьи были побудить арфистов-педагогов критически отнестись к некоторым методическим изданиям и привлечь их внимание к самостоятельной методической разработке «болевых» вопросов обучения игре на арфе.
Chemical characterization of cell-death-dependent calcification in aortic valve stenosis by Raman mapping on sections and matching against histochemical counterparts
Creators: name: Ortolani, Fulvia
name: Bonifacio, Alois
name: Bonetti, Antonella
name: Della Mora, Alberto
name: Sergo, Valter
name: Marchini, Maurizio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: raman-imaging; aortic valve stenosis; soft tissue calcification

description: Raman micro-spectroscopy is a qualitative and quantitative non-destructive analytical technique in which a monochromatic radiation emitted from a laser source is focused on a sample through microscope optics, and the light inelastically scattered by the sample is thus collected and analyzed by means of an optical spectrograph. The bands observed in Raman spectra correspond to molecular vibrations of the biochemical species constituting the sample, with each species contributing with a specific molecular “spectral fingerprint”. Exploiting this analytical capability, “chemical images” showing the distribution of different biochemical species are produced by collecting spectra from each point of the sample: an approach called “Raman mapping”. With diagnostic purposes, Raman mapping is being increasingly exploited to characterize pathological tissues. 30-mμ-thick cryosections of samples from aortic valve leaflets surgically excised from patients affected by calcific aortic valve stenosis (CAVS) were mounted on calcium-fluoride-slides for Raman-analysis. Nearly adjacent 8-mμ-thick cryosections were mounted on histological slides for histochemical analysis, including von Kossa silver staining. The localization of prominent hydroxyapatite quantities closely correlated with von Kossa staining at level of calcific nodules and single neighbouring dead cells and cell debris. In addition, Raman imaging revealed great amounts of phspholipids and cholesterol around the calcific nodules, where a distinct cell degeneneration occurs, as previuosly ultrastructurally described (Ortolani et al., Histol. Histopathol. 22, 261-272, 2007), which includes increasing in cell membranous component, its subsequent dissolution, and release/clustering of lipid-containing material acting as major hydroxyapatite nucleator. Such a lipid distribution in Raman-maps was superimposable to specific reactivity for von Kossa and Cuprolinic blue staining on histological sections. Interestingly, Raman-maps also showed further co-localization of carotenoids with lipid moiety and in particular cholesterol. In conclusion, more detailed chemical characterization was provided of the calcific process underlying CAVS by implementing histochemical and ultrastructural procedures with Raman micro-spectroscopy. In addition, considering that Raman spectra could be obtained in-vivo upon shining the laser light on the valvular tissues via an optical fiber, the intense and characteristic signal of carotenoids might be used as an optical marker for precocious diagnosis of valve calcification.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Oxidative stress and skeletal muscle in exercise
Creators: name: Castrogiovanni, Paola
name: Imbesi, Rosa
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2012
Subjects: reactive oxygen species; physical exercise

description: Reactive oxygen species (ROSs) are often associated with damage to cellular functions. ROSs production is indicatives of oxidative stress during physical exercise. Oxidative stress occurs in those circumstances in which free radicals determine a tissue damage or production of toxic and dangerous compounds for tissues. In a relaxation state, antioxidant defense of body may hold under control free radicals. Physical activity promotes specific adaptations in relation to type, intensity and duration of physical exercise performed, and a cytoprotective response in skeletal muscle is the increased production of heat shock proteins (HSPs).
 In ageing, skeletal muscle shows a series of deteriorations, and numerous data suggest that redox processes may play an important role in ageing processes.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (2012)
title: Ð¡Ð¾Ð³Ð»Ð°ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ ÑÐµÐ³ÑÐ»ÑÑÐ¸Ñ Ð¿ÑÐ¾-Ð¼Ð¸Ð¾Ð³ÐµÐ½Ð½ÑÑ Ð¸ Ð¿ÑÐ¾-Ð°Ð´Ð¸Ð¿Ð¾Ð³ÐµÐ½Ð½ÑÑ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð¿ÑÑÐµÐ¹ Ð² Ð¼Ð¸Ð¾Ð±Ð»Ð°ÑÑÐ°Ñ Ð»Ð¸Ð½Ð¸Ð¸ C2C12
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ²Ð°Ð½Ð¾Ð²Ð°, ÐÐºÑÐ°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¼Ð¸Ð¾Ð±Ð»Ð°ÑÑÑ C2C12
Ð¼Ð¸Ð¾ÑÑÑÐ±ÐºÐ¸
Ð¼Ð¸Ð¾Ð³ÐµÐ½Ð½Ð°Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÐ¾Ð²ÐºÐ°
Ð°Ð´Ð¸Ð¿Ð¾Ð³ÐµÐ½Ð½Ð°Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÑÐ¾Ð²ÐºÐ°
ÑÐ½Ðº-ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¼Ñ Ð¿ÑÐ¾Ð²ÐµÑÑÐ»Ð¸ Ð³Ð¸Ð¿Ð¾ÑÐµÐ·Ñ Ð¾ ÑÐ²ÑÐ·Ð¸ Ð¼Ð¸Ð¾Ð³ÐµÐ½Ð½ÑÑ Ð¸ Ð°Ð´Ð¸Ð¿Ð¾Ð³ÐµÐ½Ð½ÑÑ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð¿ÑÑÐµÐ¹ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¼Ð¸Ð¾Ð±Ð»Ð°ÑÑÐ¾Ð² C2C12. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð¾Ð±Ð·Ð¾Ñ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ Ð¿Ð¾ ÑÑÑÐ¾ÐµÐ½Ð¸Ñ Ð¼ÑÑÐµÑÐ½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² Ð¼Ð¸Ð¾Ð³ÐµÐ½ÐµÐ·Ð°. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð¾Ð±Ð·Ð¾Ñ ÑÐ¸ÑÑÐµÐ¼ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ Ð¼ÑÑÐµÑÐ½ÑÑ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½. ÐÑÐ»Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð¼ÐµÑÐ¾Ð´Ñ ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÑ Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹, Ð²ÐºÐ»ÑÑÐ°Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ Ð¸ ÐÐ¦Ð  Ð°Ð½Ð°Ð»Ð¸Ð·. ÐÑÑÐ²Ð»ÐµÐ½Ð¾ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð°Ð´Ð¸Ð¿Ð¾Ð³ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð° Ð½Ð° ÑÐ°Ð½Ð½Ð¸Ñ ÑÑÐ°Ð¿Ð°Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÐ¾Ð²ÐºÐ¸ Ð¼Ð¸Ð¾Ð±Ð»Ð°ÑÑÐ¾Ð².
Angiogenic marker expression in cancer stem cells derived from glioblastoma and peritumor tissue
Creators: name: Lama, Gina
name: Colabianchi, Anna
name: D’Alessio, Alessio
name: Angelucci, Cristiana
name: Proietti, Gabriella
name: De Bonis, Pasquale
name: Mangiola, Annunziato
name: Binda, Elena
name: Vescovi, Angelo
name: Maira, Giulio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Glioblastoma; cancer stem cells; angiogenesis

description: Glioblastoma (GBM) is a lethal cancer characterized by florid vascularization and aberrantly elevated VEGF. Antiangiogenic therapy with VEGF antibodies reduces GBM tumor growth. However, the clinical benefits are transient and invariably followed by tumor recurrence. Recently, it has been demonstrated that in GBM cancer stem cells (CSCs) are responsible for either tumorigenesis or neoangiogenesis. In particular, a fraction of CSCs is represented by a population of endothelial progenitors. In our previous studies, we showed the presence of nestin+ cells and nestin+ and endoglin (CD105)+ vasculature, not only in the GBM but also in the tissue surrounding the tumor, suggesting the involvement of CSC endothelial differentiation also in peritumor tissue. In this study, with the aim of understanding CSCs involvement in angiogenesis, we investigated the expression of angiogenesis markers (VEGF, VEGFR1, VEGFR2, HIF1α and HIF2α) by immunocytochemistry, western blot or real time PCR analysis, in CSCs derived from GBM (GCSC) and peritumor tissue (PCSC) of 4 patients. Both GCSCs and PCSCs were immunopositive for HIF1α and HIF2α, VEGF and its receptors VEGFR1 and VEGFR2, which underlines the presence of autocrine and paracrine growth factor loops. Immunoblotting showed that VEGF is expressed at higher levels in GCSCs than PCSCs, with the exception of a patient who showed an up-regulation in PCSCs. Moreover, real time PCR showed that both VEGFR1 and VEGFR2 were expressed at low level in the two types of CSCs with a down-regulation of VEGFR1 in PCSCs. These results indicate the presence of all angiogenic markers in PCSCs suggesting their involvement in GBM local recurrence. The inhibition of multiple angiogenic pathways may be a new line of attack on this deadly cancer.  We acknowledge Prof. Gigliola Sica for her effectiveness in coordinating this study supported by FIRB “Accordi di Programma” 2010.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Meteorology Driven Ozone Variability
Creators: name: Santra, Samrat
name: Patra, Aditya Kumar
name: Penchala, Abhishek
name: Mishra, Namrata
name: Pradhan, Dhruti Sundar
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Meteorology plays a significant role in influencing ground-level ozone (O3) concentrations that can adversely affect public health through exposure to elevated O3 levels. Currently, regulatory compliance measurements rely on large, expensive instruments that provide O3 averaged data over extended periods. In recent years, continuous air quality monitoring stations have gained popularity for real-time O3 monitoring in outdoor environments (mostly in metropolitan cities). However, there is a lack of comprehensive studies evaluating the impact of local meteorological conditions on O3 levels in both road and rural settings. This study aims to assess the interaction between major meteorological variables and O3 concentrations at a high-traffic road site and no-traffic rural site. A comparative analysis was conducted using high-precision reference instruments in uncontrolled outdoor environments. Single-factor GAM (generalized additive model) demonstrated strong performance (R2 = 0.95–0.96) and deviance explained (95–96%). When paired variables were incorporated, the multi-factor GAM further improved performance and explained 97–99% of the variability in O3 concentrations. The multi-factor GAM outperformed the GLM (generalized linear model) (R2 = 0.88–0.89) and achieved superior results (R2 = 0.979–0.987; deviance explained = 98.2–98.8%) in accurately predicting O3 levels and can be applied in various occupational environments like personal exposure monitoring among industry workers.
Fluid moment hierarchy equations derived from gauge invariant quantum kinetic theory
Creators: name: Haas, F.
name: Zamanian, J.
name: Marklund, M.
name: Brodin, G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The gauge invariant electromagnetic Wigner equation is taken as the basis for a fluid-like system describing quantum plasmas, derived from the moments of the gauge invariant Wigner function. The use of the standard, gauge dependent Wigner function is shown to produce inconsistencies, if a direct correspondence principle is applied. The propagation of linear transverse waves is considered and shown to be in agreement with the kinetic theory in the long wavelength approximation, provided an adequate closure is chosen for the macroscopic equations. A general recipe to solve the closure problem is suggested.
description: 12 pages, 1 figure
Additional file 1 of Relationship between early-onset stroke and triglyceride-glucose index among young Chinese adults
Creators: name: Xu, Wenqi
name: Zhao, Haiyan
name: Han, Xu
name: Liu, Jianrong
name: Li, Haixia
name: Sun, Junyan
name: Xing, Aijun
name: Chen, Shuohua
name: Wu, Shouling
name: Wu, Yuntao
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1: Supplementary Table 1. Stratification analysis of HRs for risk of outcomes according to quartiles of baseline TyG index. Supplementary Table 2. Sensitive analysis for hazard ratios values and 95% Confidence Intervals (CI) according to the period of baseline and follow-up. Supplementary Table 3. HRs for risk of outcomes after excluding the participants with subarachnoid hemorrhage stroke(n=11). Supplementary Table 4. HRs from Competing Risk Models for outcomes after excluding the participants with subarachnoid hemorrhage stroke(n=11).
КОМПОЗИТОРЫ-КАРАИМЫ В ИСТОРИИ РУССКОЙ МУЗЫКИ КОНЦА XIX - ПЕРВОЙ ПОЛОВИНЫ XX В
Creators: name: МАКСИМОВА АНАСТАСИЯ МИХАЙЛОВНА
Publisher: name: Вестник музыкальной науки
Year: 2019
Subjects: КАРАИМЫ
С. М. МАЙКАПАР
А. М. АЙВАЗ
В. Г. ИВАНОВ-КАПОН
ПРЕЕМСТВЕННОСТЬ
ТЕМА МАЛОЙ РОДИНЫ
ТЕМА ДЕТСТВА
KARAITES
S. M. MAIKAPAR
A. M. AIVAZ
V. G. IVANOV-KAPON
CONTINUITY
THE THEME OF A SMALL HOMELAND
THE THEME OF CHILDHOOD

description: Статья посвящена композиторам-караимам XIX-XXI вв. С. М. Майкапару, А. М. Айвазу, В. Г. Иванову-Капону. На фоне опубликованных биографических материалов их композиторское творчество все еще остается без исследовательского внимания. При этом своей творческой деятельностью авторы сформировали самобытную ветвь русской композиторской школы. В этом видится актуальность статьи необходимость всестороннего изучения жизни и творчества названных композиторов-караимов. В статье прослеживаются нити преемственности в творчестве обозначенных композиторов на уровне тематики их сочинений ведущими становятся тема малой Родины и детства. В творчестве Майкапара тема малой Родины не очень выражена, но ярко представлена в сочинениях Айваза. В его сочинениях сильны традиции петербургской композиторской школы с ее исканиями в сфере народной музыки и представлениями о музыке Востока, сложившимися в творчестве композиторов-кучкистов. У Иванова-Капона данная тема воплощается посредством обращения к фольклорным основам музыкальной культуры караимов, что делает его творчество созвучным стилевому движению новой фольклорной волны. Тема детства, ярко выраженная в творчестве Майкапара и Айваза, у Иванова-Капона воплотилась своеобразно в его деятельности в качестве композитора для детско-юношеского ансамбля «Фидан».
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð°ÑÐ³Ð¾Ð½Ð¾Ð´ÑÐ³Ð¾Ð²Ð¾Ð¹ ÑÐ²Ð°ÑÐºÐ¸ ÑÑÐ°Ð»Ð¸ 12Ð¥18Ð10Ð¢ Ñ Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÑÑÐ¸Ð¼ ÑÐ»ÑÑÐ¾Ð¼
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð¡ÑÑÐ¾ÑÑÐºÐ¾Ð², ÐÐ¸ÑÐ°Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐ»ÑÑ
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description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ðµ ÑÐ²Ð°ÑÐºÐ¸ Ð²ÑÑÐ¾ÐºÐ¾Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÑÑÐ¾Ð¼Ð¾Ð½Ð¸ÐºÐµÐ»ÐµÐ²ÑÑ Ð°ÑÑÑÐµÐ½Ð¸ÑÐ½ÑÑ ÑÑÐ°Ð»ÐµÐ¹. ÐÑÐ» Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½ ÐºÑÐ¸ÑÑÐ°Ð»Ð»Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐ»ÑÑ Ð¤ÐÐ¡Ð¢-2 (ÑÐ»ÑÑ, Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÑÑÐ¸Ð¹, Ð´Ð»Ñ ÑÐ²Ð°ÑÐºÐ¸ ÑÑÐ°Ð»ÐµÐ¹) Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ (SiO2-TiO2-LiF-AlF3). ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ ÑÐµÐ¶Ð¸Ð¼Ñ Ð°ÑÐ³Ð¾Ð½Ð¾Ð´ÑÐ³Ð¾Ð²Ð¾Ð¹ ÑÐ²Ð°ÑÐºÐ¸ Ð½ÐµÐ¿Ð»Ð°Ð²ÑÑÐ¸Ð¼ÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð¼ Ñ Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÑÑÐ¸Ð¼ ÑÐ»ÑÑÐ¾Ð¼ Ð¤ÐÐ¡Ð¢-2 ÑÑÐ°Ð»Ð¸ 12Ð¥18Ð10Ð¢. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ»ÑÑÐ° Ð½Ð° Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ ÑÐ²Ð°ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ Ð¿Ð¾ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐ¼ ÑÐµÐ¶Ð¸Ð¼Ð°Ð¼ - Ð¿Ð¾ ÑÐµÐ¶Ð¸Ð¼Ñ â 2 Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ðµ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð³Ð»ÑÐ±Ð¸Ð½Ñ Ð¿ÑÐ¾Ð¿Ð»Ð°Ð²Ð»ÐµÐ½Ð¸Ñ 32,70 %, Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ðµ ÑÑÐ¶ÐµÐ½Ð¸Ðµ ÑÐ¸ÑÐ¸Ð½Ñ ÑÐ²Ð° 26,62 %.
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¸ÐºÐ¾Ð³Ð¾ÑÑÐ½, ÐÐ°ÑÐµÐº
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸Ñ
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description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¼Ð¾Ð¶Ð½Ð¾ Ð½Ð°Ð·Ð²Ð°ÑÑ Ð¿ÑÐ°Ð²Ð¾Ð²ÑÐµ, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÑÑ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐµ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð°. Ð¦ÐµÐ»Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ - ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¼ÐµÑÑ Ð´Ð»Ñ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð² ÐÐÐ Â«Ð®ÐÐÐÐÐ (Ð Ð£Ð¡)Â». Ð¡Ð´ÐµÐ»Ð°Ð½ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð· Ð²ÑÑÑÑÐºÐ¸ Ð¸ Ð·Ð°ÑÑÐ°Ñ Ð¾Ñ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¼ÐµÑ Ð¿Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð² ÐÐÐ Â«Ð®ÐÐÐÐÐ (Ð Ð£Ð¡)Â».Ð ÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð¼ÐµÑ Ð¿Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÑ Ðº Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐ¾Ð¹ Ð¿ÑÐ¸Ð±ÑÐ»Ð¸ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸.
Relaxin and Sertoli cell proliferation
Creators: name: Nascimento, Aline R.
name: Pimenta, Maristela T.
name: Lucas, Thais F.G.
name: Porto, Catarina S.
name: Lazari, Maria F.M.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: relaxin; FSH; Sertoli cells; cell proliferation

description: Immature Sertoli cells proliferate and several factors affect their number, including the follicle stimulating hormone (FSH), testosterone, estradiol and several paracrine growth factors. Using a primary culture of Sertoli cells isolated from 15-day old Wistar rats we have shown that relaxin stimulates Sertoli cell proliferation through the activation of MEK/ERK1/2 and PI3K/AKT pathways. In contrast, FSH inhibited both ERK1/2 and AKT phosphorylation. Furthermore, FSH strongly increased cAMP production, whereas relaxin inhibited basal cAMP production. Our results indicate that in rat Sertoli cells from 15-day old rats relaxin and FSH affect the same signaling pathways in opposite directions. Interplay between both hormones may be important to control the proliferation and differentiation of Sertoli cells.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013
Growth and shape transformations of giant phospholipid vesicles upon interaction with an aqueous oleic acid suspension
Creators: name: Peterlin, Primoz
name: Arrigler, Vesna
name: Kogej, Ksenija
name: Svetina, Sasa
name: Walde, Peter
Publisher: name: arXiv
Year: 2009
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The interaction of two types of vesicle systems was investigated: micrometer-sized, giant unilamellar vesicles (GUVs) formed from 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and submicrometer-sized, large unilamellar vesicles (LUVs) formed from oleic acid and oleate, both in a buffered aqueous solution (pH=8.8). Individual POPC GUVs were transferred with a micropipette into a suspension of oleic acid/oleate LUVs, and the shape changes of the GUVs were monitored using optical microscopy. The behavior of POPC GUVs upon transfer into a 0.8 mM suspension of oleic acid, in which oleic acid/oleate forms vesicular bilayer structures, was qualitatively different from the behavior upon transfer into a 0.3 mM suspension of oleic acid/oleate, in which oleic acid/oleate is predominantly present in the form of monomers and possibly non-vesicular aggregates. In both cases, changes in vesicle morphology were observed within tens of seconds after the transfer. Vesicle initially started to evaginate. In 60% of the cases of transfer into a 0.8 mM oleic acid suspension, the evagination process reversed and proceeded to the point where the membrane formed invaginations. In some of these cases, several consecutive transitions between invaginated and evaginated shapes were observed. In the remaining 40% of the cases of transfer into the 0.8 mM oleic acid uspension and in all cases of vesicle transfer into the 0.3 mM oleic acid suspension, no invaginations nor subsequent evaginations were observed. An interpretation of the observed vesicle shape transformation on the basis of the bilayer-couple model is proposed, which takes into account uptake of oleic acid/oleate molecules by the POPC vesicles, oleic acid flip-flop processes and transient pore formation.
description: 12 pages, 8 figures, accepted for publication in Chem. Phys. Lipids
Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice
Creators: name: Smith, Craig M.
name: Hosken, Ihaia T.
name: Downer, Natalie L.
name: Chua, Berenice E.
name: Hossain, Mohammad Akhter
name: Wade, John D.
name: Gundlach, Andrew L.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: Relaxin-3, RXFP3, feeding, arousal, motivation, knockout

description: The neuropeptide relaxin-3 and its cognate G-protein-coupled receptor, RXFP3, have been implicated in the control of feeding behaviour in rats. For example, relaxin-3-positive projections and RXFP3 are present within hypothalamic feeding circuits, and icv injection of human relaxin-3 (~0.2 to 1.0 nmol) robustly increases feeding behaviour in satiated rats. To explore whether this action is conserved in other experimental species, the present study examined feeding behaviour in C57BL/6J mice following RXFP3 modulation, as mice display near identical regional distribution patterns of relaxin-3/RXFP3, and relaxin-3/RXFP3 signalling has been shown to modulate behavioural arousal in both species. Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment. Furthermore, relaxin-3 knockout mice displayed similar basal 24-h chow consumption and 1-h palatable food consumption to wildtype littermate controls; although further studies involving acute pharmacological antagonism of RXFP3 in WT mice are required to eliminate the likelihood of compensation in these life-long relaxin-3 deficient mice. Taken together, these findings are in contrast to the potent orexigenic effects of RXFP3 activation observed in rats, and may reflect differential RXFP3 expression within hypothalamic neuron populations in the rat and mouse, or differences in signalling upstream or downstream of relaxin-3/RXFP3 networks in these two species.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013
On the Feedback Efficiency of Active Galactic Nuclei
Creators: name: Kurosawa, Ryuichi
name: Proga, Daniel
name: Nagamine, Kentaro
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: (Abridged) We measure and analyze the energy, momentum, and mass feedback efficiencies due to radiation from AGN in relatively large scale outflows. Our measurements are based on the axisymmetric and time-dependent radiation-hydrodynamical simulations recently presented in Kurosawa & Proga. These simulations follow dynamics of gas under the influences of the AGN radiation and the gravity of the central 10^8 Msun black hole on scales from ~0.01 to ~10pc. We compare our Mdot_a-rho_o relation with that predicted by the Bondi accretion model. For high luminosities comparable to the Eddington limit, the power-law fit (Mdot_a ~ rho_o^q) to our models yields q=~0.5 instead of q=1.0 which is predicted by the Bondi model. This difference is caused by the outflows which are important for the overall mass budget at high luminosities. The maximum momentum and mass feedback efficiencies found in our models are ~10^-2 and ~10^-1, respectively. However, the outflows are much less important energetically: their thermal and kinetic powers in units of the radiative luminosity are ~10^-5 and ~10^-4, respectively. The efficiencies do not increase monotonically with the accretion luminosity but rather peak around the Eddington limit beyond which a steady state disk-wind-like solution exists. Our energy feedback efficiencies are significantly lower than 0.05, which is required in some cosmological and galaxy merger simulations. The low feedback efficiencies found here could have significant implications on the mass growth of super massive black holes in the early universe. We stress however that we have not considered the innermost parts of the accretion and outflow where radiation and matter interact most strongly. The feedback from this region could have efficiencies significantly above the low values found here.
description: 11 pages, 6 figures, accepted for publication in ApJ
title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð³Ð°Ð·Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð² Ð¿Ð½ÐµÐ²Ð¼Ð¾Ð¿ÑÐ¸Ð²Ð¾Ð´Ð°Ñ
title: Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ¾Ð½ÑÐºÐ¾Ð¹, ÐÐ½Ð°ÑÐ¾Ð»Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: ÐÐ½ÐµÐ²Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿ÑÐ¸Ð²Ð¾Ð´Ñ
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description: ÐÐ·Ð»Ð°Ð³Ð°ÑÑÑÑ Ð¼ÐµÑÐ¾Ð´Ñ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°Ð±Ð¾ÑÐ¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð² Ð¿Ð½ÐµÐ²Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð°Ñ Ð¸ ÑÑÑÐ±Ð¾Ð¿ÑÐ¾Ð²Ð¾Ð´Ð°Ñ.
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Relaxin, cardiac stem cells and heart regeneration
Creators: name: Silvia, Lucia
name: Nistri, Silvia
name: Sassoli, Chiara
name: Bani, Daniele
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: relaxin; heart; cardiac stem cells; mesenchymal stromal cells

description: The notion that the adult heart of mammals including humans contain a small population of resident cardiac progenitor/stem cells (CSCs) have questioned the traditional paradigm of the myocardium as a post-mitotic terminally differentiated tissue. These cells, however, are relatively scarce and unable to be recruited in large number at the site of tissue damage. This has sparkled novel interest in the identification of molecules capable of stimulating the regenerative potentials of CSCs in their microenvironment. In this context, the peptide hormone relaxin (RLX), recently validated as a cardiovascular hormone, deserves a key place. This article summarizes the most recent findings of our group on the ability of RLX to modulate growth and differentiation of mouse neonatal cardiomyocytes, suggesting that this hormone, for which the heart is both a source and target organ, may participate in the endogenous mechanisms of myocardial repair/regeneration. Moreover, we have recently observed that RLX, by a Notch-1-mediated mechanism, inhibits cardiac myofibroblast differentiation and function, suggesting that the known anti-fibrotic effects of RLX may be part of a complex network of actions whereby this hormone facilitates cardiac stem cell growth and improves myocardial regeneration.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013
К ИССЛЕДОВАНИЮ ПРОВИНЦИАЛЬНОЙ МУЗЫКАЛЬНОЙ ЖИЗНИ В УЕЗДНЫХ ГОРОДАХ КРЫМСКОГО ПОЛУОСТРОВА (НА ПРИМЕРЕ ЯЛТЫ И ЕВПАТОРИИ)
Creators: name: ДУБРОВСКАЯ МАРИНА ЮЗЕФОВНА
Publisher: name: Вестник музыкальной науки
Year: 2019
Subjects: ПРОВИНЦИАЛЬНАЯ МУЗЫКАЛЬНАЯ ЖИЗНЬ ЮГА ТАВРИЧЕСКОЙ ГУБЕРНИИ
ПОСЛЕДНЯЯ ЧЕТВЕРТЬ XIX НАЧАЛО XX ВВ
УЕЗДНЫЕ ГОРОДА КРЫМА
ЯЛТА
ЕВПАТОРИЯ
ИРМО
КОРЕННЫЕ НАРОДЫ
РАЗЛИЧИЯ В ИСХОДНЫХ ПОЗИЦИЯХ ФОРМИРОВАНИЯ АКАДЕМИЧЕСКОЙ МУЗЫКАЛЬНОЙ КУЛЬТУРЫ
PROVINCIAL MUSICAL LIFE OF THE SOUTH OF TAURIDA PROVINCE
THE LAST QUARTER OF THE XIX EARLY XX CENTURIES
COUNTY TOWNS OF CRIMEA
YALTA
EVPATORIA
IMPERIAL RUSSIAN MUSICAL SOCIETY
INDIGENOUS PEOPLES
DIFFERENCES IN THE INITIAL POSITIONS OF THE FORMATION OF ACADEMIC MUSICAL CULTURE

description: В статье впервые представлены некоторые результаты сравнительного исследования явлений формирования академической музыкальной жизни и образования в последнюю четверть XIX начале XX вв. в двух провинциальных уездных городах юга Таврической губернии: Ялте и Евпатории. В опоре на подходы российского гуманитарного знания, исследования и публикации крымских авторов и собственные изыскания автора осуществляется выявление разительных отличий базисных для развития академической музыкальной культуры элементов в Ялте и Евпатории. В их числе наличие в Ялте отделения ИРМО и отсутствие такового в Евпатории, различный количественный и этнический состав населения двух городов, приоритетность и соответственно благоустроенность курортной зоны Ялты в сравнении с Евпаторией, количественное и качественное преобладание в Ялте гастролеров корифеев столичной музыкальной жизни. Однако данные отличия не умаляют достижений музыкальной культуры Евпатории, которая развивалась в иной плоскости (силами представителей коренных народов Крыма). Рассмотрение двух феноменов уездной музыкальной культуры Юга дореволюционной России в исторической перспективе позволило сделать вывод о немалом значении и Ялты, и Евпатории в формировании в Крыму профессионального композиторского творчества не только русского, но и иного национального генезиса в силу доминирования в Евпатории этнических традиций коренных народов Крыма, в частности, караимов и греков.
Localization of the autonomic, somatic and sensory neurons innervating the cranial tibial muscle of the pig
Creators: name: Botti, Maddalena
name: Gazza, Ferdinando
name: Ragionieri, Luisa
name: Bo Minelli, Luisa
name: Panu, Rino
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: cranial tibial muscle; pig; retrograde neuronal tracer; Fast Blue

description: The location of sympathetic, somatic and sensory neurons projecting to the cranial tibial muscle of the pig hindlimb was studied with the neuronal non-transynaptic tracer Fast Blue. Additionally, the number and the size of these neurons were determinated. The Fast blue, randomly applied to the cranial tibial muscle belly of 3 pigs, labelled sympathetic neurons in the ipsilateral L5-S3 and contralateral S1 sympathetic trunk ganglia and in the prevertebral caudal mesenteric ganglia of both sides. The somatic motoneurons were identified in the ipsilateral ventral horn of the S1 segment of spinal cord, while the sensory neurons were located in the ipsilateral L7-S1 spinal ganglia. The diameter of the multipolar sympathetic neurons oscillated between 26 and 46 µm in the sympathetic trunk ganglia and between 18 and 42 µm in the caudal mesenteric ganglia. The size of the multipolar spinal motoneurons oscillated between 33 and 102 µm. The size of the pseudounipolar sensory neurons oscillated between 23 and 67 µm. In all ganglia, the labelled neurons were localized at random and did not show a somatotopic distribution. Our results document a conspicuous autonomic innervation projecting to the “classic” skeletal cranial tibial muscle. Probably this innervation is destined to the muscle vessels.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (2011)
title: Ð¢ÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¿ÑÐ¾ÑÐµÑÑ Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð´ÐµÑÐ°Ð»Ð¸ Â«ÐÐ°Ð» Ð¿ÐµÑÐ²Ð¸ÑÐ½ÑÐ¹Â»
title: Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½ÑÐ¹ Ð¿ÑÐ¾ÐµÐºÑ
titleType: Subtitle
Creators: name: Ð¨Ð°ÑÐºÐ¸Ð½, ÐÑÑÐµÐ¼
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ° Ð´ÐµÑÐ°Ð»ÐµÐ¹
ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¿ÑÐ¾ÑÐµÑÑ
ÑÐ¾ÐºÐ°ÑÐ½ÑÐ¹ ÑÑÐ°Ð½Ð¾Ðº

description: Ð Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½Ð¾Ð¼ Ð¿ÑÐ¾ÐµÐºÑÐµ ÑÐ´ÐµÐ»Ð°Ð½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÑÐµÑÑÐ²ÑÑÑÐµÐ³Ð¾ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÐÐ°Ð»Ð° Ð¿ÐµÑÐ²Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ ÐµÐ³Ð¾ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐºÐ¸. Ð¡Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¿ÑÐ¾ÑÐµÑÑ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÐ¾ÐºÐ°ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÐºÐ° Ñ Ð§ÐÐ£, Ð·ÑÐ±Ð¾Ð´Ð¾Ð»Ð±ÐµÐ¶Ð½Ð¾Ð³Ð¾, Ð·ÑÐ±Ð¾ÑÑÐµÐ·ÐµÑÐ½Ð¾Ð³Ð¾, Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð¾-ÑÐ²ÐµÑÐ»Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸ ÐºÑÑÐ³Ð»Ð¾ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÐºÐ¾Ð². Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð°Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ°Ñ Ð¾ÑÐ½Ð°ÑÑÐºÐ° Ð½Ð° ÑÐ²ÐµÑÐ»Ð¸Ð»ÑÐ½ÑÑ Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ñ. Ð¢Ð°ÐºÐ¶Ðµ ÑÐºÐ¾Ð½ÑÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾-Ð¸Ð·Ð¼ÐµÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð¿ÑÐ¸ÑÐ¿Ð¾ÑÐ¾Ð±Ð»ÐµÐ½Ð¸Ðµ. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð²Ð¾Ð¿ÑÐ¾ÑÑ ÑÐµÑÐ½Ð¸ÐºÐ¸ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ Ð¸ ÑÐ´ÐµÐ»Ð°Ð½Ð¾ ÑÐµÑÐ½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾ÐµÐºÑÐ°.
title:  Giurisprudenza nazionale ed europea e frammentazione legislativa della responsabilità civile del provider
Creators: name: Sica  ,  Salvatore
Publisher: name: Roma TrE-Press
Year: 2021

description: Il contributo espone i problemi di interpretazione sollevati dalla disciplina della responsabilità del provider. Quindi, passa in rassegna la giurisprudenza in materia di responsabilità dell’internet provider, per rilevare come non sembra avviarsi a compimento il percorso che, in materia, muove dalle corti nazionali, passa per quelle europee (CGUE e CtEDU), per approdare ad un livello di stabilizzazione credibile del tema. L’incertezza continua a regnare sovrana e, in questo contesto, è difficile azzardare l’esito finale. La sola certezza è che il circuito tra la giurisprudenza nazionale ed europea è indispensabile, anche come unico tracciato in cui si possa ritrovare il filo delle regole giuridiche emanazione di scelte valoriali condivise, oggi smarrito nel caos (non casuale) che il governo economico dei processi ha generato.
description: National Judges and the Case Law of the Court of Justice of the European Union
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÐÑÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð·Ð¾Ð½Ñ Ð Ð¤ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÑÑÐ¼Ð°Ð½ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
Creators: name: ÐÑÐ¼Ð°Ð·Ð°, ÐÐ±Ð´ÐµÑÑÐ°ÑÐ¼Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐÑÑÐ¼Ð°Ð½ÑÐºÐ°Ñ Ð¾Ð±Ð»Ð°ÑÑÑ
ÐÑÐºÑÐ¸ÑÐµÑÐºÐ°Ñ Ð·Ð¾Ð½Ð°
Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ðµ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ
ÑÐµÐ³Ð¸Ð¾Ð½Ñ

description: Ð¦ÐµÐ»ÑÑ Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¾Ð¹ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ ÑÐ²Ð»ÑÐµÑÑÑ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ°Ð²Ð¾Ð²Ð¾Ð³Ð¾ ÑÐµÐ¶Ð¸Ð¼Ð° Ð½ÐµÐ´ÑÐ¾Ð¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð½Ð° Ð°ÑÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¼ Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²Ðµ Ð¸ Ð¾ÑÐµÐ½ÐºÐ° Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð² ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ ÐÑÐºÑÐ¸ÐºÐ¸ Ð² ÐºÐ¾Ð½ÑÐµÐºÑÑÐµ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð² Ð¸ ÑÐ°ÑÑÐ¸ÑÐµÐ½Ð¸Ñ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐµÐ¹ Ð¡ÐµÐ²ÐµÑÐ½Ð¾Ð³Ð¾ Ð¼Ð¾ÑÑÐºÐ¾Ð³Ð¾ Ð¿ÑÑÐ¸. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿ÑÐ°Ð²Ð¾Ð²Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð±ÑÐ» Ð¾ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð¾Ð²Ð°Ð½ Ð¿ÑÐ°Ð²Ð¾Ð²Ð¾Ð¹ ÑÑÐ°ÑÑÑ Ð°ÑÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÐ¸ÑÐ¾ÑÐ¸Ð¹ Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ ÑÑÐ¸Ð´Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÑÐ¾Ð·ÑÐ¹ÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð² ÑÑÐ¾Ð¼ ÑÐµÐ³Ð¸Ð¾Ð½Ðµ. ÐÑÐ»Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÐµ Ð¼ÐµÑÑ ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ñ Ð»Ð¾Ð³Ð¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÑÐ°ÑÑÑÑÐºÑÑÑÑ ÑÐµÐ²ÐµÑÐ½ÑÑ Ð³Ð¾ÑÐ¾Ð´Ð¾Ð²-Ð¿Ð¾ÑÑÐ¾Ð² Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÑÑÐ°Ð½Ð³ÐµÐ»ÑÑÐºÐ° Ð¸ ÐÑÑÐ¼Ð°Ð½ÑÐºÐ°.
ГИМНОГРАФИЧЕСКИЙ КОМПЛЕКС СВЯТИТЕЛЮ ФИЛИППУ МИТРОПОЛИТУ МОСКОВСКОМУ
Creators: name: КАЗАНЦЕВА ДАРЬЯ ВАСИЛЬЕВНА
Publisher: name: Вестник музыкальной науки
Year: 2019
Subjects: МИТРОПОЛИТ ФИЛИПП МОСКОВСКИЙ И ВСЕЯ РУСИ
ЗНАМЕННЫЙ РАСПЕВ
ГИМНОГРАФИЧЕСКИЙ КОМПЛЕКС
РЕДАКЦИИ
METRAPOLITAN OF MOSCOW AND ALL RUSSIA PHILIP
ZMAMENY CHANT
GYMNOGRAPHIC COMPLEX
EDITION

description: В настоящей статье рассматривается гимнографический комплекс, посвященный митрополиту Московскому и всея Руси Филиппу, становление агиографии которому до сих пор оставляет много вопросов. В связи с этим затрагиваются вопросы, связанные с датой канонизации святителя Филиппа, временем сложения жития и составления службы, а также ее певческого воплощения. Исследователями установлено, что певческие списки службы митрополиту Филиппу появляются в середине XVII в. Достаточное количество вариантов музыкального текста службы святителю позволяет осуществить их систематизацию через выяснение точного числа реально существующих певческих редакций и их соотношения между собой. На основании наиболее ранних и репрезентативных списков службы, не переходящих границы XVIII в., были обнаружены две категории гимнографических текстов, среди которых тексты, исполняющиеся на подобен и имеющие самостоятельный напев. Основной материал статьи посвящен выявлению репертуара песнопений службы митрополиту московскому Филиппу. Анализ показал, что комплекс песнопений святителю в выбранных списках представлен в разном объеме. Их сопоставление позволило выделить пять редакций состава службы, отличающихся количеством входящих песнопений -основную, краткую, расширенную, полную, избыточную.
title: ÐÐµÐ¼ÐµÑÐºÐ¸Ð¹ ÑÐ·ÑÐº. ÐÐ°Ð·Ð¾Ð²ÑÐ¹ ÐºÑÑÑ. Ð¡Ð±Ð¾ÑÐ½Ð¸Ðº Ð»ÐµÐºÑÐ¸ÐºÐ¾-Ð³ÑÐ°Ð¼Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ¿ÑÐ°Ð¶Ð½ÐµÐ½Ð¸Ð¹. Ð§. 2
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ°ÑÐ¿Ð¾Ð²Ð¸Ñ, ÐÑÐ¸Ð½Ð°
name: ÐÑÐµÐ¿ÐºÐ°Ñ, Ð¢Ð°ÑÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð½ÐµÐ¼ÐµÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
Ð»ÐµÐºÑÐ¸ÐºÐ¾Ð»Ð¾Ð³Ð¸Ñ
Ð³ÑÐ°Ð¼Ð¼Ð°ÑÐ¸ÐºÐ°
ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ·Ð¾Ð²

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