cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of Early Pancreatic Graft Loss on Outcome after Simultaneous Pancreas–Kidney Transplantation (SPKT)—A Landmark Analysis
Creators: name: Lehner, Lukas Johannes
name: Öllinger, Robert
name: Globke, Brigitta
name: Naik, Marcel G.
name: Budde, Klemens
name: Pratschke, Johann
name: Eckardt, Kai-Uwe
name: Kahl, Andreas
name: Zhang, Kun
name: Halleck, Fabian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: simultaneous kidney-pancreas transplantation
subject: kidney transplantation
subject: pancreas transplantation
subject: diabetes mellitus type I
subject: graft loss
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: (1) Background: Simultaneous pancreas-kidney transplantation (SPKT) is a standard therapeutic option for patients with diabetes mellitus type I and kidney failure. Early pancreas allograft failure is a complication potentially associated with worse outcomes. (2) Methods: We performed a landmark analysis to assess the impact of early pancreas graft loss within 3 months on mortality and kidney graft survival over 10 years. This retrospective single-center study included 114 adult patients who underwent an SPKT between 2005 and 2018. (3) Results: Pancreas graft survival rate was 85.1% at 3 months. The main causes of early pancreas graft loss were thrombosis (6.1%), necrosis (2.6%), and pancreatitis (2.6%). Early pancreas graft loss was not associated with reduced patient survival (p = 0.168) or major adverse cerebral or cardiovascular events over 10 years (p = 0.741) compared to patients with functioning pancreas, after 3 months. Moreover, kidney graft function (p = 0.494) and survival (p = 0.461) were not significantly influenced by early pancreas graft loss. (4) Conclusion: In this study, using the landmark analysis technique, early pancreas graft loss within 3 months did not significantly impact patient or kidney graft survival over 10 years.
title: Investigation of Aircraft Accident: CALIFORNIA ARROW AIRLINES: NEAR VALLEJO, CALIFORNIA: 1949-12-07
Creators: name: Civil Aeronautics Board
Publisher: name: Civil Aeronautics Board
Year: 1949
Subjects: classificationCode: https://trt.trb.org/term/90718
subject: Crash analysis
classificationCode: https://trt.trb.org/term/90683
subject: Crash causes
classificationCode: https://trt.trb.org/term/90697
subject: Crash characteristics
classificationCode: https://trt.trb.org/term/90719
subject: Crash investigation
classificationCode: https://trt.trb.org/term/90647
subject: Crash types
classificationCode: https://trt.trb.org/term/87909
subject: Air transportation
classificationCode: https://trt.trb.org/term/90648
subject: Air transportation crashes
classificationCode: https://trt.trb.org/term/91987
subject: Airlines
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety
classificationCode: https://trt.trb.org/term/90771
subject: Casualties
classificationCode: https://trt.trb.org/term/92063
subject: Civil aviation
classificationCode: https://trt.trb.org/term/90775
subject: Fatalities
classificationCode: https://trt.trb.org/term/90773
subject: Injury rates
classificationCode: https://trt.trb.org/term/90774
subject: Injury severity
classificationCode: https://trt.trb.org/term/91785
subject: Passengers
classificationCode: https://trt.trb.org/term/90757
subject: Fires

description: Civil Aeronautics Board
68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma
Creators: name: Graef, Josefine
name: Furth, Christian
name: Kluge, Anne Kathrin
name: Acker, Gueliz
name: Kord, Melina
name: Zimmermann, Zoe
name: Amthauer, Holger
name: Makowski, Marcus
name: Loebel, Franziska
name: Vajkoczy, Peter
name: Budach, Volker
name: Senger, Carolin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: 68Ga-DOTATOC
subject: hybrid imaging
subject: optic nerve sheath meningioma
subject: PET/MRI
subject: robotic radiosurgery
subject: stereotactic radiotherapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Simple Summary: Through combined information about spatial spread in magnetic resonance imaging (MRI) and positron emission tomography (PET), gallium-68-labeled (DOTA0-Phe1-Tyr3) octreotide (Ga68-DOTATOC) PET/MRI before radiosurgery allows safe treatment planning for optic nerve sheath meningiomas (ONSM). Moreover, because of specific receptor stocking, diagnostic accuracy is improved without the need for biopsy. Thus, Ga68-DOTATOC-PET/MRI can be considered a safe "one-stop shop" image tool prior to radiosurgery for ONSM. Abstract: Optic nerve sheath meningiomas (ONSM) are rare but can lead to irreversible blindness. Hybrid imaging may enhance tumor delineation and diagnostic accuracy via receptor binding. However, relevant clinical data for ONSM are lacking. We evaluated the feasibility of receptor-based hybrid imaging prior to robotic radiosurgery (RRS). We retrospectively analyzed all of our institution's patients with suspected ONSM who underwent combined positron emission tomography and magnetic resonance imaging (PET/MRI) with gallium-68-labeled (DOTA0-Phe1-Tyr3) octreotide (Ga68-DOTATOC) before RRS between 2018 and 2019. Eight patients with ten suspected ONSM (female = 7; median age, 51.2 years; IQR, 43.0-66.0) were included. Nine out of ten ONSM were deemed PET-positive with a median standard uptake value (SUV) max of 5.6 (IQR, 2.6-7.8). For all nine ONSM that presented 68Ga-DOTATOC uptake, hybrid PET/MRI was used for target volume contouring prior to RSS. At a median follow-up of 11.7 months (IQR, 9.4-16.4), tumor control was achieved in all patients. Radiosurgery resulted in the improvement of visual acuity in two of eight patients, whereas six showed stable vision. Ga68-DOTATOC-PET/MRI can be used for target volume contouring prior to RRS for ONSM as it enables safe treatment planning and improves diagnostic accuracy.
Spectroscopic study of the O-type runaway supergiant HD 195592
Creators: name: De Becker, M.
name: Linder, N.
name: Rauw, G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The scope of this paper is to perform a detailed spectroscopic study of the northern O-type supergiant HD 195592. We use a large sample of high quality spectra in order to investigate its multiplicity, and to probe the line profile variability. Our analysis reveals a clear spectroscopic binary signature in the profile of the He {\sc i} $λ$ 6678 line, pointing to a probable O + B system. We report on low amplitude radial velocity variations in every strong absorption line in the blue spectrum of HD 195592. These variations are ruled by two time-scales respectively of 5.063 and about 20 days. The former is firmly established, whilst the latter is poorly constrained. We report also on a very significant line profile variability of the H $β$ line, with time scales strongly related to those of the radial velocities. Our results provide significant evidence that HD 195592 is a binary system, with a period that might be the variability time-scale of about 5 days. The second time scale may be the signature of an additional star moving along a wider orbit provided its mass is low enough, even though direct evidence for the presence of a third star is still lacking. Alternatively, the second time-scale may be the signature of a variability intrinsic to the stellar wind of the primary, potentially related to the stellar rotation.
description: 9 pages, 5 postscript figures, accepted for publication in New Astronomy
title: "Orient in Berlin": Asien und Afrika in Kultur, Politik und Gelehrsamkeit gestern, heute und morgen
Creators: name: Haarmann, Ulrich
Publisher: name: Zentrum Moderner Orient
Year: 2013
Subjects: subject: Berlin
subject: Orientalistik
subject: 943
subject: 950

description: ZMO Programmatic Texts, no. 5
Systematic variation in the apparent burning area of thermonuclear bursts and its implication for neutron star radius measurement
Creators: name: Bhattacharyya, Sudip
name: Miller, M. Coleman
name: Galloway, Duncan K.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Precision measurements of neutron star radii can provide a powerful probe of the properties of cold matter beyond nuclear density. Beginning in the late 1970s it was proposed that the radius could be obtained from the apparent or inferred emitting area during the decay portions of thermonuclear (type I) X-ray bursts. However, this apparent area is generally not constant, preventing reliable measurement of the source radius. Here we report for the first time a correlation between the variation of the inferred area and the burst properties, measured in a sample of almost 900 bursts from 43 sources. We found that the rate of change of the inferred area during decay is anticorrelated with the burst decay duration. A Spearman rank correlation test shows that this relation is significant at the <10^{-45} level for our entire sample, and at the 7x10^{-37} level for the 625 bursts without photospheric radius expansion. This anticorrelation is also highly significant for individual sources exhibiting a wide range of burst durations, such as 4U 1636-536 and Aql X-1. We suggest that variations in the colour factor, which relates the colour temperature resulted from the scattering in the neutron star atmosphere to the effective temperature of the burning layer, may explain the correlation. This in turn implies significant variations in the composition of the atmosphere between bursts with long and short durations.
description: 8 pages, 4 figures, accepted for publication in MNRAS
title: Investigation of Aircraft Accident: CAPITAL AIRLINES: WASHINGTON NATIONAL AIRPORT, WASHINGTON D.C.: 1949-12-12
Creators: name: Civil Aeronautics Board
Publisher: name: Civil Aeronautics Board
Year: 1949
Subjects: classificationCode: https://trt.trb.org/term/90718
subject: Crash analysis
classificationCode: https://trt.trb.org/term/90683
subject: Crash causes
classificationCode: https://trt.trb.org/term/90697
subject: Crash characteristics
classificationCode: https://trt.trb.org/term/90719
subject: Crash investigation
classificationCode: https://trt.trb.org/term/90647
subject: Crash types
classificationCode: https://trt.trb.org/term/87909
subject: Air transportation
classificationCode: https://trt.trb.org/term/90648
subject: Air transportation crashes
classificationCode: https://trt.trb.org/term/91987
subject: Airlines
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety
classificationCode: https://trt.trb.org/term/90771
subject: Casualties
classificationCode: https://trt.trb.org/term/92063
subject: Civil aviation
classificationCode: https://trt.trb.org/term/90775
subject: Fatalities
classificationCode: https://trt.trb.org/term/90773
subject: Injury rates
classificationCode: https://trt.trb.org/term/90774
subject: Injury severity
classificationCode: https://trt.trb.org/term/91785
subject: Passengers
classificationCode: https://trt.trb.org/term/90757
subject: Fires

description: Civil Aeronautics Board
Integrability of invariant metrics on the diffeomorphism group of the circle
Creators: name: Constantin, Adrian
name: Kolev, Boris
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 35Q35, 35Q53, 37K10, 37K65

description: Each H^k Sobolev inner product defines a Hamiltonian vector field X_k on the regular dual of the Lie algebra of the diffeomorphism group of the circle. We show that only X_0 and X_1 are bi-Hamiltonian relatively to a modified Lie-Poisson structure.
Probing nucleon-nucleon interactions in breakup of a one-neutron halo $^{11}$Be on a proton target
Creators: name: Cravo, E.
name: Crespo, R.
name: Moro, A. M.
name: Deltuva, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A comparison between full few-body Faddeev/Alt-Grassberger-Sandhas (Faddeev/AGS) and continuum-discretized coupled channels (CDCC) calculations is made for the resonant and nonresonant breakup of $^{11}$Be on proton target at 63.7 MeV/u incident energy. A simplified two-body model is used for $^{11}$Be which involves an inert $^{10}$Be(0$^+$) core and a valence neutron. The sensitivity of the calculated observables to the nucleon-nucleon potential dynamical input is analysed. We show that with the present NN and N-core dynamics the results remain a puzzle for the few-body problem of scattering from light exotic halo nuclei.
description: To be published Phys Rev Rapid Communication
Expression Silencing of Glutathione Peroxidase 4 in Mouse Erythroleukemia Cells Delays In Vitro Erythropoiesis
Creators: name: Rademacher, Marlena
name: Kuhn, Hartmut
name: Borchert, Astrid
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: cell differentiation
subject: lipid peroxidation
subject: oxidative stress
subject: eicosanoids
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Among the eight human glutathione peroxidase isoforms, glutathione peroxidase 4 (GPX4) is the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols. In mice, corruption of the Gpx4 gene leads to embryonic lethality and more detailed expression silencing studies have implicated the enzyme in several physiological processes (e.g., embryonal cerebrogenesis, neuronal function, male fertility). Experiments with conditional knockout mice, in which expression of the Gpx4 gene was silenced in erythroid precursors, indicated a role of Gpx4 in erythropoiesis. To test this hypothesis in a cellular in vitro model we transfected mouse erythroleukemia cells with a Gpx4 siRNA construct and followed the expression kinetics of erythropoietic gene products. Our data indicate that Gpx4 is expressed at high levels in mouse erythroleukemia cells and that expression silencing of the Gpx4 gene delays in vitro erythropoiesis. However, heterozygous expression of a catalytically inactive Gpx4 mutant (Gpx4(+/Sec46Ala)) did not induce a defective erythropoietic phenotype in different in vivo and ex vivo models. These data suggest that Gpx4 plays a role in erythroid differentiation of mouse erythroleukemia cells but that heterozygous expression of a catalytically inactive Gpx4 is not sufficient to compromise in vivo and ex vivo erythropoiesis.
Who is the culprit: Is pest infestation responsible for crop yield losses close to semi-natural habitats?
Creators: name: Raatz, Larissa
name: Walzl, Karin Pirhofer
name: Müller, Marina E. H.
name: Scherber, Christoph
name: Joshi, Jasmin
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: arable weeds
subject: cereal leaf beetle
subject: fungal pathogens
subject: herbivory
subject: structural equation model
subject: wheat
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Semi-natural habitats (SNHs) are becoming increasingly scarce in modern agricultural landscapes. This may reduce natural ecosystem services such as pest control with its putatively positive effect on crop production. In agreement with other studies, we recently reported wheat yield reductions at field borders which were linked to the type of SNH and the distance to the border. In this experimental landscape-wide study, we asked whether these yield losses have a biotic origin while analyzing fungal seed and fungal leaf pathogens, herbivory of cereal leaf beetles, and weed cover as hypothesized mediators between SNHs and yield. We established experimental winter wheat plots of a single variety within conventionally managed wheat fields at fixed distances either to a hedgerow or to an in-field kettle hole. For each plot, we recorded the fungal infection rate on seeds, fungal infection and herbivory rates on leaves, and weed cover. Using several generalized linear mixed-effects models as well as a structural equation model, we tested the effects of SNHs at a field scale (SNH type and distance to SNH) and at a landscape scale (percentage and diversity of SNHs within a 1000-m radius). In the dry year of 2016, we detected one putative biotic culprit: Weed cover was negatively associated with yield values at a 1-m and 5-m distance from the field border with a SNH. None of the fungal and insect pests, however, significantly affected yield, neither solely nor depending on type of or distance to a SNH. However, the pest groups themselves responded differently to SNH at the field scale and at the landscape scale. Our findings highlight that crop losses at field borders may be caused by biotic culprits; however, their negative impact seems weak and is putatively reduced by conventional farming practices.
The influence of alternate course locations on distances travelled by participants in urban adult evening classes
Creators: name: Melton, James Edward
Publisher: name: University of British Columbia
Year: 2011

description: The distances travelled by non-credit evening class participants of two adult education institutions, the University of British Columbia Extension Department and the Vancouver School Board Night Schools, were studied by means of the analytic survey method. The participants in most of the non-credit courses offered on the campus by the Extension Department in one term were included in the study. A much smaller sample population of courses was selected from the three major night school centers operated by the Vancouver School Board. The participants of both institutions were grouped into two categories, Unique or Common. Unique participants were those who could obtain the course they attended at that one location only. Common participants were those who could have chosen alternative course locations. The distances travelled from place of residence to course location by Unique and Common Extension participants were compared as were the distances travelled by Unique and Common night school participants. The chi-square test of independence was used in the comparisons of the distributions of Unique and Common participants while the significance of the differences between the mean distances travelled and between the median distances travelled was determined by the use of critical ratios. The .01 level of confidence was the criterion used to determine the significance of differences. Distances travelled by Extension participants were found not to be influenced by alternative course locations in the same community when these alternatives were public school night school centers. Participants came from the whole of metropolitan Vancouver and distance did not seem to be a barrier within this area. Alternative course location in comparable centers in the community was found to influence the travel patterns of public school night school participants. Courses available at a single location attracted participants from the whole community whereas courses offered at three locations tended to attract participants more from the neighborhood of the center. Although there was some participation from the greater metropolitan area, the night schools tended more to serve the city alone than did the Extension Department. These findings suggest that the usefulness or necessity of additional Extension course locations in the metropolitan area is questionable. However, an increase in the number of public school evening course locations would seem likely to yield increased participation providing care was taken to avoid the competition which may result when new locations are placed too close to existing ones.
title: Investigation of Aircraft Accident: CAPITAL AIRLINES: NEAR WASHINGTON NATIONAL AIRPORT, WASHINGTON, D.C.: 1949-12-12
Creators: name: Civil Aeronautics Board
Publisher: name: Civil Aeronautics Board
Year: 1949
Subjects: classificationCode: https://trt.trb.org/term/90718
subject: Crash analysis
classificationCode: https://trt.trb.org/term/90683
subject: Crash causes
classificationCode: https://trt.trb.org/term/90697
subject: Crash characteristics
classificationCode: https://trt.trb.org/term/90719
subject: Crash investigation
classificationCode: https://trt.trb.org/term/90647
subject: Crash types
classificationCode: https://trt.trb.org/term/87909
subject: Air transportation
classificationCode: https://trt.trb.org/term/90648
subject: Air transportation crashes
classificationCode: https://trt.trb.org/term/91987
subject: Airlines
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety
classificationCode: https://trt.trb.org/term/90771
subject: Casualties
classificationCode: https://trt.trb.org/term/92063
subject: Civil aviation
classificationCode: https://trt.trb.org/term/90775
subject: Fatalities
classificationCode: https://trt.trb.org/term/90773
subject: Injury rates
classificationCode: https://trt.trb.org/term/90774
subject: Injury severity
classificationCode: https://trt.trb.org/term/91785
subject: Passengers
classificationCode: https://trt.trb.org/term/90757
subject: Fires

description: Civil Aeronautics Board
title: Язык анатомии для иностранцев, изучающих русский язык
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебное пособие представляет собой комплекс заданий по языку анатомии, знакомит студентов со специальной лексикой по анатомии и грамматическими конструкциями научного стиля речи. Издание содержит адаптированные тексты из школьных учебников, посвященные описанию основных систем организма человека. Адресовано иностранцам, владеющим русским языком в объёме базового уровня (А2). Может быть рекомендовано для изучения дисциплины «Научный стиль речи» в аудитории с преподавателем.
Chasing the non-linear evolution of matter power spectrum with numerical resummation method: solution of closure equations
Creators: name: Hiramatsu, Takashi
name: Taruya, Atsushi
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a new numerical scheme to treat the non-linear evolution of cosmological power spectra. Governing equations for matter power spectra have been previously derived by a non-perturbative technique with closure approximation. Solutions of the resultant closure equations just correspond to the resummation of an infinite class of perturbation corrections, and they consistently reproduce the one-loop results of standard perturbation theory. We develop a numerical algorithm to solve closure evolutions in both perturbative and non-perturbative regimes. The present numerical scheme is particularly suited for examining non-linear matter power spectrum in general cosmological models, including modified theory of gravity. As a demonstration, we study weakly non-linear evolution of power spectrum in a class of modified gravity models, as well as various dark energy models.
description: 17 pages, 8 figures; Fig.3 updated and typos fixed
Replication of cowpox virus in macrophages is dependent on the host range factor p28/N1R
Creators: name: Bourquain, Daniel
name: Schrick, Livia
name: Tischer, Bernd Karsten
name: Osterrieder, Klaus
name: Schaade, Lars
name: Nitsche, Andreas
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Orthopoxvirus
subject: Cowpox virus
subject: Host range
subject: p28
subject: RING finger
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Zoonotic orthopoxvirus infections continue to represent a threat to human health. The disease caused by distinct orthopoxviruses differs in terms of symptoms and severity, which may be explained by the unique repertoire of virus factors that modulate the host’s immune response and cellular machinery. We report here on the construction of recombinant cowpox viruses (CPXV) which either lack the host range factor p28 completely or express truncated variants of p28. We show that p28 is essential for CPXV replication in macrophages of human or mouse origin and that the C-terminal RING finger domain of p28 is necessary to allow CPXV replication in macrophages.
Strategic directions of fighting obesity as a leading method for reducing a stroke pathology
Creators: name: Mishchenko, Marina M.
name: Shevchenko, Alexander S.
name: Mishchenko, Alexander N.
Publisher: name: Zenodo
Year: 2020

description: К тезисам [Mishchenko MM, Shevchenko AS, Mishchenko AN. Strategic directions of fighting obesity as a leading method for reducing a stroke pathology. Proceedings of the International scientific-practical conference "Medicine of the XXI century: perspective and priority directions of scientific researches" (Dnipro, July 24-25, 2020). Dnipro: Organization of scientific medical research "Salutem". P. 84-9. https://doi.org/10.5281/zenodo.3971034] первоисточники (архивные копии): 03 In English: [Pletsuga, O.I. (2018) Laparoscopic sleeve resection of the stomach in the treatment of obese patients. The dissertation ... Ph.D. in the specialty 14.01.03 "Surgery". Kyiv, National Institute of Surgery and Transplantology named after O.O. Shalimov of the National Academy of Medical Sciences of Ukraine, 181 p. Архивная копия: https://doi.org/10.5281/zenodo.3971072] Українською: [Плецуга, О.І. (2018) Лапароскопічна рукавна резекція шлунка в лікуванні хворих на ожиріння. Дисертація ... к.мед.н. за спеціальністю 14.01.03 «Хірургія». Київ, Національний інститут хірургії та трансплантології імені О.О. Шалімова Національної академії медичних наук України, 181 с. Архивная копия: https://doi.org/10.5281/zenodo.3971072]
El buen uso del lenguaje desde la lingüística chilena: entrevista a Guillermo Andrés Soto Vergara
Creators: name: Delgado Del Aguila, Jesús Miguel
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 470499
subject: Linguistics not elsewhere classified

description: Delgado Del Aguila, Jesús Miguel (2025). «El buen uso del lenguaje desde la lingüística chilena: entrevista a Guillermo Andrés Soto Vergara», en: Argus-a. Artes & Humanidades. Buenos Aires, Argentina: Editorial Argus-a. Vol. XIV, n.° 55, marzo, pp. 1-11. Disponible en https://argus-a.org/archivos-dinamicas/1863-1.pdf
The strand-biased transcription of SARS-CoV-2 and unbalanced inhibition by remdesivir
Creators: name: Zhao, Yan
name: Sun, Jing
name: Li, Yunfei
name: Li, Zhengxuan
name: Xie, Yu
name: Feng, Ruoqing
name: Zhao, Jincun
name: Hu, Yuhui
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: virology
subject: mathematical biosciences
subject: systems biology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive single-stranded RNA virus, causes the coronavirus disease 19 pandemic. During the viral replication and transcription, the RNA-dependent RNA polymerase “jumps” along the genome template, resulting in discontinuous negative-stranded transcripts. Although the sense-mRNA architectures of SARS-CoV-2 were reported, its negative strand was unexplored. Here, we deeply sequenced both strands of RNA and found SARS-CoV-2 transcription is strongly biased to form the sense strand with variable transcription efficiency for different genes. During negative strand synthesis, numerous non-canonical fusion transcripts are also formed, driven by 3-15 nt sequence homology scattered along the genome but more prone to be inhibited by SARS-CoV-2 RNA polymerase inhibitor remdesivir. The drug also represses more of the negative than the positive strand synthesis as supported by a mathematic simulation model and experimental quantifications. Overall, this study opens new sights into SARS-CoV-2 biogenesis and may facilitate the antiviral vaccine development and drug design.
Environmental Effects on the Star Formation Activity in Galaxies at z=1.2 in the COSMOS Field
Creators: name: Ideue, Y.
name: Nagao, T.
name: Taniguchi, Y.
name: Shioya, Y.
name: Saito, T.
name: Murayama, T.
name: Sasaki, S. S.
name: Trump, J. R.
name: Koekemoer, A. M.
name: Aussel, H.
name: Capak, P.
name: Ilbert, O.
name: McCracken, H.
name: Mobasher, B.
name: Salvato, M.
name: Sanders, D. B.
name: Scoville, N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the relation between the star-formation activity in galaxies and environment at z=1.2 in the COSMOS field, using the fraction of [OII] emitters and the local galaxy density. The fraction of [OII] emitters appears to be almost constant over the surface density of galaxies between 0.2 and 10 Mpc^-2. This trend is different from that seen in the local universe where the star-formation activity is weaker in higher density regions. To understand this difference between z~1 and z~0, we study the fraction of non-isolated galaxies as a function of local galaxy density. We find that the fraction of non-isolated galaxies increases with increasing density. Our results suggest that the star formation in galaxies at z~1 is triggered by galaxy interaction and/or mergers.
description: 10pages, 5figures, accepted for publication in ApJ
The role of MEC-17/αTAT1 in nervous system integrity and repair
Creators: name: TEOH, JEAN - SEBASTIEN KWOH Z
Publisher: name: Monash University
Year: 2021
Subjects: classificationCode: 320999
subject: Neurosciences not elsewhere classified

description: Neurons extend cable-like axons throughout the body to communicate with each other and other cells. Keeping these axons intact is critical for our nervous system’s function. In fact, disruptions to axons are associated with many human disorders, which are frequently incurable because our body lacks effective repair mechanisms. In this thesis, we have studied internal structures in axons, known as microtubules. We discovered that two microtubule-associated proteins are required to prevent the axon structure from degrading and to repair itself. Our findings add to our understanding of how neurons can keep their axons intact and repair themselves when injured.
Features of exceptional points and the continuum spectroscopy
Creators: name: Okolowicz, J.
name: Ploszajczak, M.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss observable features of exceptional points and the resonance spectroscopy of $^{16}$Ne using the Shell Model Embedded in the Continuum.
description: 10 pages, 4 figures Zakopane Conference on Nuclear Physics, September 1-7, 2008, Zakopane, Poland
Stability, causality and quasinormal modes of cosmic strings and cylinders
Creators: name: Pavan, Alan B.
name: Abdalla, E.
name: Molina, C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work we consider the evolution of a massive scalar field in cylindrically symmetric space-times. Quasinormal modes have been calculated for static and rotating cosmic cylinders. We found unstable modes in some cases. Rotating as well as static cosmic strings, i.e., without regular interior solutions, do not display quasinormal oscillation modes. We conclude that rotating cosmic cylinder space-times that present closed time-like curves are unstable against scalar perturbations.
description: 13 pages, 3 figures, 6 graph files, 4 tables
The Bottom Billion: Why the Poorest Countries are Failing and What Can be Done about it (by Paul Collier) - A Discussion
Creators: name: Nelson, Hank
Publisher: name: Canberra, ACT: State, Society and Governance in Melanesia (SSGM), Research School of Pacific and Asian Studies, The Australian National University
Year: 2008

description: Former Director of Development Research at the World Bank and now Professor of Economics and Director of the Centre for the Study of African Economies at Oxford University, Paul Collier has produced a broad, condensed, accessible book about why one sixth of the world's population suffers long-term poverty and what can and should be done about it. Given Collier's status in research and practice, the significance of the issues he raises and the critical reception of his book, his arguments deserve careful examination by those concerned with aid policy and its implementation.
Phases of hot and dense QCD matter
Creators: name: Blaizot, Jean-Paul
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: This talk summarizes some of the theoretical issues currently most debated in the field of hot and dense QCD matter and ultra-relativistic heavy ion collisions.
description: 6 pages, 1 figure, invited talk at the 10th International Conference on Nucleus-Nucleus Collisions, Aug 16-21, 2009, Beijing, China
The role of MEC-17/αTAT1 in nervous system integrity and repair
Creators: name: TEOH, JEAN - SEBASTIEN KWOH Z
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 320999
subject: Neurosciences not elsewhere classified

description: Neurons extend cable-like axons throughout the body to communicate with each other and other cells. Keeping these axons intact is critical for our nervous system’s function. In fact, disruptions to axons are associated with many human disorders, which are frequently incurable because our body lacks effective repair mechanisms. In this thesis, we have studied internal structures in axons, known as microtubules. We discovered that two microtubule-associated proteins are required to prevent the axon structure from degrading and to repair itself. Our findings add to our understanding of how neurons can keep their axons intact and repair themselves when injured.
Decoding Transcriptional Control of Germline Development in Caenorhabditis elegans
Creators: name: CAO, WEI
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310404
subject: Evolution of developmental systems

description: Regulation of gene expression is important for driving germ cell development, however, little is known regarding the function of transcriptional regulators in this process. To identify transcriptional regulators that are important for germ cell development, these genes were knocked down one by one, and the impact on the germline and reproduction were examined. In this analysis, germline cell-autonomous regulators and germline non-cell-autonomous regulators were discovered. Subsequent analysis on a previously uncharacterized gene F43G9.12 determined its cell-autonomous roles in the germline, likely through both transcriptional regulation and post-transcriptional process.
11.2% Efficient Germanium TPV Cells Measured Under High-Temperature Irradiance Conditions
Creators: name: Medrano Gómez, Álvaro Manuel
name: López, Esther
name: Garcia-Linares, Pablo
name: Villa Morales, Juan
name: Rivera Vila, Gerard
name: Gamel, Mansur Mohammed Ali
name: López, Gema
name: Garín Escrivá, Moisés
name: Martín García, Isidro
name: DEL CAÑIZO NADAL, CARLOS
name: Datas, Alejandro
Publisher: name: Zenodo
Year: 2025
Subjects: subject: thermophotovoltaic
subject: Photovoltaic

description: Germanium is a low-cost alternative to the highly expensive III-V semiconductors commonly used on thermophotovoltaic (TPV) devices. Despite efficiencies up to 16.5 % having been theorized in previous works, no experimental efficiencies have been reported so far for germanium-based devices. In this work, we present the first experimental germanium TPV cell efficiency measured under high view factor and high temperature irradiance conditions. Efficiencies and electric power densities up to 11.2 % and 1.43 W/cm2 have been obtained using a graphite emitter heated at 1440ºC.
Maximum L$q$-likelihood estimation
Creators: name: Ferrari, Davide
name: Yang, Yuhong
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62F99 (Primary) 60F05, 94A17, 62G32 (Secondary)

description: In this paper, the maximum L$q$-likelihood estimator (ML$q$E), a new parameter estimator based on nonextensive entropy [Kibernetika 3 (1967) 30--35] is introduced. The properties of the ML$q$E are studied via asymptotic analysis and computer simulations. The behavior of the ML$q$E is characterized by the degree of distortion $q$ applied to the assumed model. When $q$ is properly chosen for small and moderate sample sizes, the ML$q$E can successfully trade bias for precision, resulting in a substantial reduction of the mean squared error. When the sample size is large and $q$ tends to 1, a necessary and sufficient condition to ensure a proper asymptotic normality and efficiency of ML$q$E is established.
description: Published in at http://dx.doi.org/10.1214/09-AOS687 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Kaluza-Klein modes of bulk fields in a generalized Randall-Sundrum scenario
Creators: name: Mitra, Joydip
name: SenGupta, Soumitra
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a generalised two brane Randall-Sundrum model with non-zero cosmological constant on the visible TeV brane. Massive Kaluza-Klein modes for various bulk fields namely graviton, gauge field and antisymmetric second rank Kalb-Ramond field in a such generalized Randall-Sundrum scenario are determined. The masses for the Kaluza-Klein excitations of different bulk fields are found to depend on the brane cosmological constant indicating interesting consequences in warped brane particle phenomenology
description: 12 Pages, 1 Figure
title: Учим русский от А до Я. Готовимся к ТРКИ-1 (В1)
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии важная роль отводится работе над лексикой. Это обусловлено тем, что иностранные учащиеся нередко ошибаются при выполнении заданий на различение значений слов. Правильность употребления русской лексики напрямую связана с уровнем сформированности фонетических, грамматических навыков и умений, с объемом активного словаря обучаемых слушателей. В связи с этим представлены задания, совершенствующие фонетические и грамматические навыки и умения. Также есть упражнения, развивающие умения иностранцев пользоваться моделями русской речи. Предназначено для иностранных слушателей подготовительных факультетов, а также для студентов бакалавриата 1-го и 2-го курсов, владеющих русским языком на уровне, приближенном к B1.
1/f noise and slow relaxations in glasses
Creators: name: Amir, Ariel
name: Oreg, Yuval
name: Imry, Yoseph
Publisher: name: arXiv
Year: 2009
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Recently we have shown that slow relaxations in the electron glass system can be understood in terms of the spectrum of a matrix describing the relaxation of the system close to a metastable state. The model focused on the electron glass system, but its generality was demonstrated on various other examples. Here, we study the noise spectrum in the same framework. We obtain a remarkable relation between the spectrum of relaxation rates $λ$ described by the distribution function $P(λ) \sim 1/λ$ and the $1/f$ noise in the fluctuating occupancies of the localized electronic sites. This noise can be observed using local capacitance measurements. We confirm our analytic results using numerics, and also show how the Onsager symmetry is fulfilled in the system.
Rational polymyxin triple combination therapy against polymyxin-resistant multidrug-resistant (MDR) Klebsiella pneumoniae using a system pharmacology approach
Creators: name: AYE, SU MON
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 310799
subject: Microbiology not elsewhere classified
classificationCode: 321499
subject: Pharmacology and pharmaceutical sciences not elsewhere classified
classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Antibiotic resistance is a serious threat to global health. Due to the lack of new antibiotics and emergence of resistance to the last-line polymyxins, developing effective antibiotic combinations against 'superbugs' is of utmost importance. This thesis is the first to identify a synergistic polymyxin-based triple combination against multidrug-resistant Klebsiella pneumoniae, elucidate the potential mechanism of enhanced antibacterial killing, and propose a potential effective dosage regimen for critically-ill patients. This thesis has made a substantial contribution to polymyxin pharmacology and the optimisation of combination therapy for the treatment of life-threatening infections caused by multidrug-resistant K. pneumoniae.
ABC News/Ipsos Poll: 2020 Coronavirus Wave 16
Creators: name: ABC News
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Concern about coronavirus (COVID-19) (1); support/oppose re-opening of public schools with in-school instruction (1); concern about children falling behind in education because of coronavirus (1); willingness to do activities currently (during coronavirus pandemic) (15).
Tests for jumps in yield spreads
Creators: name: Winkelmann, Lars
name: Yao, Wenying
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: High-frequency data
subject: sequential testing
subject: news announcements
subject: term spread
subject: break-even inflation
subject: 300 Sozialwissenschaften::330 Wirtschaft::339 Makroökonomie und verwandte Themen

description: This paper develops high-frequency econometric methods to test for jumps in the spread of bond yields. We derive a coherent inference procedure that detects a jump in the yield spread only if at least one of the two underlying bonds displays a jump. We formalize the test as a sequential procedure in the context of an intersection union test in multiple testing and introduce a new bivariate jump test for pre-averaged intra-day returns. In an empirical application involving high-frequency data of U.S. government bonds, we contrast response patterns of term spreads and break-even inflation across monetary policy announcements, inflation, and employment news releases.
Service Users’ Experiences of “Paranoia” on Psychiatric Wards
Creators: name: Cox, Georgina
Publisher: name: University of East London
Year: 2022

description: Background: Research suggests that admission to an inpatient psychiatric ward can have a detrimental impact on service users’ mental health and may give rise to distressing and traumatising experiences. However, there has been limited exploration or conceptual development regarding how or why this may occur, and what the emotional response to these experiences may be. Paranoia can be conceptualised as an emotional threat response to anxiety-provoking and unsafe environments. Consequently, the current study aims to fill a gap in the literature by considering how admission to a psychiatric ward may give rise to experiences which lead people to feel unsafe, threatened, suspicious and paranoid. Aim: This study aimed to explore what service users perceive to be the factors which influence their experience of paranoia on psychiatric wards and therefore consider what services could do differently to alleviate experiences of paranoia. Methods: Eight semi-structured interviews were conducted with service users who had previously accessed inpatient psychiatric services. Transcripts were analysed using Thematic Analysis. Results: The current study found that service users’ experiences of paranoia during admission to inpatient psychiatric wards were influenced by five overarching themes: (1) feeling disbelieved, persecuted, stigmatised and discarded (2) feeling unsure of what was going on (3) experiencing the ward as an unsafe place to be (4) paranoia as a coping mechanism and (5) moments of care and connection. A description of these themes and accompanying subthemes is presented. Conclusion: The findings indicate that a range of factors can influence service users’ experiences of paranoia on inpatient psychiatric wards which can lead to mistrust of the mental health system, staff, and other service users. The findings also highlight that certain factors can alleviate paranoia and support a positive inpatient experience. Results have implications for policy, practice, and Clinical Psychology, and support the incorporation of paranoia-reducing practices into Trauma-Informed Care approaches implemented on inpatient psychiatric wards.
Clustering at 74 MHz
Creators: name: de Oliveira-Costa, Angelica
name: Capodilupo, John
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In order to construct accurate point sources simulations at the frequencies relevant to 21 cm experiments, the angular correlation of radio sources must be taken into account. Using the 74 MHz VLSS survey, we measured the angular 2-point correlation function, w(θ). We obtain the first measurement of clustering at the low frequencies relevant to 21 cm tomography. We find that a single power law with shape w(θ) = A θ^{-γ} fits well the data. For a galactic cut of 10 degrees, with a data cut of δless than -10 degrees, and a flux limit of S = 770 mJy, we obtain a slope of γ= (-1.2 +/- 0.35). This value of γis consistent with that measured from other radio catalogues at the millimeter wavelengths. The amplitude of clustering has a length of 0.2 degrees - 0.6 degrees, and it is independent of the flux-density threshold.
description: 7 pages, 5 figures, 3 tables. Submitted to MNRAS
Unsupervised Learning Methods for Molecular Simulation Data
Creators: name: Glielmo, Aldo
name: Husic, Brooke E.
name: Rodriguez, Alex
name: Clementi, Cecilia
name: Noé, Frank
name: Laio, Alessandro
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Redox reactions
subject: Algorithms
subject: Diffusion
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Unsupervised learning is becoming an essential tool to analyze the increasingly large amounts of data produced by atomistic and molecular simulations, in material science, solid state physics, biophysics, and biochemistry. In this Review, we provide a comprehensive overview of the methods of unsupervised learning that have been most commonly used to investigate simulation data and indicate likely directions for further developments in the field. In particular, we discuss feature representation of molecular systems and present state-of-the-art algorithms of dimensionality reduction, density estimation, and clustering, and kinetic models. We divide our discussion into self-contained sections, each discussing a specific method. In each section, we briefly touch upon the mathematical and algorithmic foundations of the method, highlight its strengths and limitations, and describe the specific ways in which it has been used-or can be used-to analyze molecular simulation data.