cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sexual Attitudes and Motivations in Same-Sex and Mixed-Sex Relationships
Creators: name: Armstrong, Heather L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Sexual Attitudes
Bisexuality
Female Sexuality
Relationships
Same-Sex Attraction
Sexual Motivation

description: People engage in sex for a wide variety of reasons and these reasons can differ depending on the individual, his or her partner, and on the context of the sexual encounter. The purpose of this dissertation was to examine how sexual attraction and sexual orientation, of both self and partner, affect an individual’s reasons to engage in sex, or sexual motivation. Three studies were conducted to explore these effects from both the individual’s and the partner’s perspective. In Study 1, individual attitudes toward having casual sex, dating, and being in a committed relationship with a bisexual partner of the other gender were examined in a sample of 720 men and women. Participants reported negative attitudes toward having these relationships and more negative attitudes were reported as the commitment level of the considered relationship increased. Women also reported more negative attitudes and greater insecurity toward relationships than men. In Study 2, the psychometric properties of a comprehensive research tool, the Why Have Sex? (YSEX?) questionnaire to use in Study 3 for the study of sexual motivation were evaluated in a sample of 146 women with same-sex attraction. Overall, the reliability of this scale was excellent for casual sex motivations and motivations for sex in committed relationships with female partners. In Study 3, motivations for sex and the effects of relationship context, sexual attraction, and the gender of one’s partner were explored in a sample of 510 women including women with same-sex attraction and women with exclusively heterosexual attraction. Results of this study showed that relationship context had the largest effect on sexual motivation; physical motivations were more strongly endorsed for casual sex while emotional motivations were more strongly endorsed for sex in committed relationships. No effect of sexual attraction was reported. Further, no effect of gender of partner was reported by sexual minority women. The results of this dissertation have important implications for the study of sexual motivation, specifically as it relates to sexual attraction and orientation. Motivations for sex are likely to be affected by an individual’s attitudes and perceptions of his or her partner’s sexual orientation and associated stereotypes. In addition, the type of sexual relationship and associated level of commitment had strong, differential effects on sexual motivation. This is a novel finding as the context of the sexual relationship has not previously been considered with respect to individual motivations for sex. Henceforth, studies on sexual motivation need to be more contextualized and include more comprehensive assessments of individuals to increase the validity of findings and demonstrate the complex variation of human sexual motivation.
Limbal stem cell deficiency secondary to systemic paclitaxel (Taxol) for breast cancer: a case report
Creators: name: Sekhon, Amardeep
name: Wang, Jeff Y. F.
name: Tan, Johnson C. H.
name: Holland, Simon P.
name: Yeung, Sonia N.
Publisher: name: BioMed Central
Year: 2020

description: Background: Paclitaxel (PTX) is an antineoplastic drug widely used in treatments for ovarian, breast, and small-cell lung cancer. Although ocular effects associated with PTX have been previously described, very few studies have specifically reported systemic PTX as a contributing factor for limbal stem cell deficiency (LSCD), which is characterized by the loss of stem cell and barrier function of the limbus leading to progressive pain and reduction in visual acuity. Described here is a unique case where a patient was diagnosed with LSCD secondary to PTX use for the treatment of breast cancer, at doses of PTX far lower than what is reported in current literature. Case presentation: A 73-year-old woman with a previous diagnosis of breast cancer with liver metastasis presented with a complaint of increasing pain in the left eye more than the right, along with decreasing visual acuity in both eyes following 3 months of PTX therapy for recurrent liver metastases. Upon examination, best-corrected visual acuity was 20/100 in the right eye and counting fingers on the left. Peripheral neovascularization, stromal scarring, and features of limbal stem cell deficiency (LSCD) were noted on the right cornea. A central neurotrophic ulcer with thinning to 50% and 360 degrees of conjunctivalization were noted on the left. After the discontinuation PTX with doxorubicin as the substitute, there was no further progression of her LSCD, and stabilization of her ocular surface was achieved. Conclusion: Although chemotherapy induced LSCD is a relatively rare adverse event, it is essential for clinicians starting new chemotherapy agents to consider the potential ocular toxicities that may result in their use. Ophthalmology review is recommended for patients after starting PTX therapy to assess for signs of LSCD, particularly in patients where drug toxicity can be aggravated due to impaired hepatic function.
New Perovskite Materials for Sensors and Low Temperature Solid Oxide Fuel Cell (LT-SOFC) Applications
Creators: name: Bukhari, Syed Munawer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Perovskite oxides
Reduction stability
Reducing gases
Sensors
SOFC
Anode materials
Coke resistant
n-type material
p-type material
Low temperature

description: This work involved the development of new perovskite oxides based on SmFeO3 and testing their performances as sensors for reducing gases (H2, CO & CH4) and as anode materials for dry methane oxidation in solid oxide fuel cells. The new perovskite oxide materials with formula Sm0.95Ce0.05Fe1-xMxO3-δ (M= Co, Ni & Cr) were synthesized by a sol gel method using citric acid as a complexing agent. The resulting materials were characterized by using a battery of techniques including XRD, XRF, XPS, SEM and electrochemical methods. Sensing experiments revealed that both cobalt doped and Cr doped materials can detect H2, CO and CH4 in air at different temperatures including room temperature. The Ni doped materials did not prove good candidates as sensors. However, their reduction treatment studies showed the formation of metallic nanoparticles on the surface which deeply influence their electrical conductivity as well as sensing ability. Consequently, this modification in surface structure and chemical composition enabled them to sense hydrogen gas at 300oC very effectively. The response of sensors based on these reduced materials was measurable and reversible. Some materials were also selected on the basis of their reduction stability and electrical properties, and their electrochemical performances were evaluated as SOFC anodes under dry methane and dry hydrogen fuels separately. The performance tests as SOFC anode revealed that the best anode material for the oxidation of dry hydrogen fuel is Sm0.95Ce0.05FeO3-δ. Furthermore, Sm0.95Ce0.05FeO3-δ proved to be coke resistant anode under dry methane fuel and exhibited reasonably low charge transfer resistance values at temperatures between 600-700oC. The doping of Co and Ni at the B-site of Sm0.95Ce0.05FeO3-δ found to be very effective in further improving its performance as SOFC anode towards oxidation of dry methane fuel at the lower temperatures.
Proteomic Analysis Identifies Translationally Controlled Tumor Protein as a Potential Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension
Creators: name: Lavoie, Jessie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Pulmonary arterial hypertension
Endothelial cells
Proteomics

description: Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation of pulmonary vascular cells, such as endothelial cells (ECs). Hereditary (H) PAH is mainly caused by ―loss-of-function‖ mutations in the gene coding for the bone morphogenetic protein type II receptor (BMPR2). However, the mechanisms by which these mutations cause PAH remain unclear. The hypothesis of this thesis was that BMPR2 mutations produce an imbalance in EC protein expression and/or activity that is integrally related to the development of abnormalities in lung vascular function and structure in HPAH. Patient-specific blood-outgrowth endothelial cells (BOECs) expanded ex vivo from peripheral blood mononuclear cells from patients with HPAH and healthy subjects were used to examine the consequences of BMPR2 mutations on the BOEC protein expression profile as well as on their functionality. Functional analyses of the BOECs revealed that HPAH-derived BOECs are more susceptible to apoptosis and more proliferative compared with healthy controls. Protein isolates of BOECs from patients with HPAH and from healthy subjects were subjected to 2-D gel electrophoresis and stained for total proteins and phosphoproteins, and to a quantitative computerassisted analysis. Differentially regulated proteins were identified by mass spectrometry (LC-MS/MS). Of the 416 total proteins detected under basal conditions, 11 were significantly downregulated in HPAH-derived BOECs and 11, including the translationally controlled tumor protein (TCTP), were upregulated. TCTP has previously been shown to be involved in systemic arteriolar remodeling, inflammation and growth. Therefore, the potential role of TCTP in PAH was studied in vivo in the SU5416 rat model of severe angioproliferative PAH. Immunofluorescence staining revealed high expression of TCTP in arteriolar ECs of PAH lungs tightly localized to proliferating cells within occlusive intimal lesions; whereas, only minimal TCTP expression was seen in vascular ECs of normal lungs. Similarly, abundant TCTP immunostaining was also seen in human PAH lung sections, again associated with complex vascular lesions. In BOECs, TCTP was found to participate in cell growth and survival. These data suggest that TCTP could play an important role in PAH by mediating pro-survival and growth signaling in vascular cells, contributing to occlusive pulmonary vascular remodeling triggered by EC apoptosis.
Spectacle and Resistance in the Modern and Postmodern Eras
Creators: name: Berthelot, Martin R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Guy Debord
Society of the Spectacle
Situationist International
Jean Baudrillard
Hyperreality
Media
Capitalism
Resistance
Cinema
Film
Avant-garde
Self-reflexivity
Alternative Media
Art
Video
Video Art
Self-referential
System theory

description: The advanced stage of capitalism that we now live in has brought many changes to the way that society consumes and produces. One of the biggest shifts to the modern economy was the use of visual culture to distract, pacify, and exert power over the masses; a cultural change French theorist Guy Debord named the Society of the Spectacle. As a result, Debord and the Situationist International developed a movement of resistance to reclaim the territories of everyday life being eroded by the spectacle through separation and alienation. Since the term was coined the use of visual culture has accelerated and become even more pervasive in the postmodern world which led Jean Baudrillard to claim that the real has been replaced by simulation and hyperreality. This thesis explores this cultural shift to determine whether the practices of resistance theorized by Debord and the Situationists are still relevant as the reach of postmodernism increases. Link to associated video file: https://vimeo.com/64727252
Microcystin production revisited: conjugate formation makes a major contribution
Creators: name: Meissner, Sven
name: Fastner, Jutta
name: Dittmann, Elke
Publisher: name: My University
Year: 2013

description: The impact of environmental stimuli on the productionof the widespread cyanobacterial hepatotoxinmicrocystin (MC) is under debate. Whereas transcriptionalstudies of the biosynthetic genes suggest aclear influence of light conditions on toxin productionthe data for the metabolite itself are inconsistent andhighly strain-specific. Here, we have reassessed theMC content by using two immunological detectiontechniques that allow a parallel quantification of MCin the methanolic extracts and the residual pellet fractionthat contains high molecular weight proteins. Ourresults show a significant proportion of MC in theprotein bound fraction in strains of Microcystis andPlanktothrix and of the related toxin nodularin (NOD)in Nodularia. Moreover, we could show a very strongincrease of MC after high light illumination in theprotein fraction contributing to a significant overallincrease in MC production under these conditionsthat is not seen in extracts analysed by LC-MS andELISA. The fact that a considerable portion of MC isneglected with current analysis techniques was alsoconfirmed for selected field samples. Immunofluorescencestudies suggest strain-specific differences inthe amount of MC conjugate formation.Quelle: Environmental Microbiology (2013) 15(6), 1810-1820
Male-Type and Prototypal Depression Trajectories for Men Experiencing Mental Health Problems
Creators: name: Rice, Simon M.
name: Kealy, David
name: Seidler, Zac E.
name: Oliffe, John Lindsay
name: Levant, Ronald F.
name: Ogrodniczuk, John S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Growing interest in gender-sensitive assessment of depression in men has seen the development of male-specific screening tools. These measures are yet to be subject to longitudinal latent modelling, which limits evidence about the ability of these tools to detect change, especially relative to established screening scales. In this study, three waves of data were collected from 234 men (38.35 years, SD = 14.09) including 3- and 6-month follow-up. Analyses focused on baseline differences and symptom trajectories for the Patient Health Questionnaire (PHQ; prototypic symptoms) and the Male Depression Risk Scale (MDRS; male-type symptoms). At baseline, men not accessing treatment reported higher MDRS scores relative to treatment-engaged men. There was no group difference for the PHQ. Internal consistency (α, ω) coefficients indicated comparable reliability for both measures across the three waves. Multidomain latent growth modelling, including current treatment engagement as a covariate, reported good model fit (CFI = 0.964, TLI = 0.986, RMSEA = 0.081, SRMR = 0.033) with differential findings for the PHQ and MDRS. Consistent with the baseline between-group analysis, current treatment effects were observed for the MDRS, but not the PHQ. Trajectory modelling for the MDRS indicated that greater severity resulted in slower improvement by 6 months. In contrast, there was no difference in the PHQ rate of change between baseline and 6 months. Findings support the psychometric utility of the MDRS as a male-specific symptom domain measure sensitive to both longitudinal change and potential treatment effects for symptomatic men, in ways not discernible by the PHQ. The MDRS may be a useful adjunctive screening tool for assessing men’s depression.
Commercialisation and competition in public sector authorities: a case study in hunting with the hares and running with the hounds
Creators: name: Kloot, Louise
name: Clulow, Val
Publisher: name: Swinburne
Year: 2024

description: New Public Management has spread to many government jurisdictions over the last 15 years. It relies on principles of commercialisation, competition, and corporatisation. How do governments maintain control of commercialised public sector bodies? Is the notion of control of a commercialised public sector organisation appropriate, given the competitive marketplaces in which many of these bodies operate? This research discovered conflicts between public sector oversight bodies set up to assist, monitor and control commercialised organisations, and commercialised organisations over issues of senior executive remuneration. These conflicts bring into the question the very notion of 'government' commercialised organisations.
La question de l’ethnicité au Rwanda
Creators: name: Rurangwa, Jean-Marie Vianney
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Rwanda
ethnicité
Hutu
Twa
Tutsi

description: Ce travail qui est une recherche qualitative sur l'ethnicité au Rwanda nous a montré que les critères d'autodéfinition, d'auto-attribution ou d'attribution par les autres à une catégorie ethnique ainsi que la dichotomisation « nous » versus « eux » font que les Hutu, les Twa et les Tutsi sont groupes ethniques distincts malgré la communauté de culture et d'espace géographique. La recherche nous a montré ensuite que les drames répétitifs (pogromes, exils, génocide) qui ont endeuillé le peuple rwandais pendant plusieurs décennies ne sont pas dus à une haine atavique ou viscérale entre les Hutu et les Tutsi mais à une idéologie raciste dont les origines remontent aux temps de la colonisation. La recherche nous a montré enfin que le problème ethnique se pose chaque fois que le pouvoir monopolisé par une poignée de politiciens (Hutu ou Tutsi suivant les époques), commence à être mis en cause. In this work I use qualitative documentary research to explore the problem of ethnicity in Rwanda. I find out that self-definition, self-attribution, and attribution by others, as well as the dichotomization of “us versus them” are sufficient criteria f categorize the Hutus, Tutsis, and Twas as distinct ethnic groups in spite of the community of culture (language, custom, and religion) and of geographic space.My research also shows that the continual conflicts (pogroms, exile, and genocide) that have plagued Rwandan people for several decades are not due to an atavistic or visceral hatred between Hutus and Tutsis, but rather the result of a racist ideology whose roots lie deep in the colonial period. This work has allowed me to confirm the thesis of my research, that the “problem of ethnicity in Rwanda is stoked by an elite (whether Tutsi or Hutu depending on the era) who set their sights on seizing and maintaining power”.
Intra-grating sensing with a chirped fibre Bragg grating employing an integration method
Creators: name: Kitcher, D. J.
name: Nand, A.
name: Wade, Scott
name: Jones, R.
name: Baxter, G. W.
name: Collins, S. F.
Publisher: name: Swinburne
Year: 2024

description: A method to recover arbitrary temperature profiles along a chirped fibre Bragg grating sensor is presented. We demonstrate a nonlinear lookup table method to recover the shape, width and position of a disturbance in temperature after compensating for distortions in the result of integrating changes in the power reflectance spectrum.
The importance of shear wave velocity information of a soil site
Creators: name: Asten, M.
name: Lam, N.
name: Venkatesan, S.
name: Rutter, H.
name: Wilson, John
Publisher: name: Swinburne
Year: 2024

description: Micro-tremor surveys based on the single-station horizontal/vertical spectral ratio (HVSR) method have typically been used to determine the potential seismic hazard of a soil site. This approach assumes that sites possessing similar natural periods have similar levels of hazard. In a micro-tremor survey undertaken by the authors, multiple dominant site periods varying in the order of between 0.3 sec and 1 sec were observed on a flexible soil site. The shear wave velocity model of the site obtained by the microtremor array method with the spatial auto-correlation (SPAC) processing technique revealed a 95 m thick layer of probable gravels underlying thin layers of sands and soft silts. Earthquake simulation analyses carried out in accordance with the modelled shear wave velocity profile indicate a 30 mm maximum seismic displacement demand of the site for a 500 year return period earthquake. Had the shear wave velocity information not been available, the site seismic hazard predicted in accordance with the measured site period of 1 sec would have been much more onerous.
Traveling Wave Solutions of Integro-differential Equations of One-dimensional Neuronal Networks
Creators: name: Hao, Han
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Traveling wave solution
Neuronal network
Integral-differential equation

description: Traveling wave solutions of integro-differential equations for modeling one-dimensional neuronal networks, are studied. Under moderate continuity assumptions, necessary and sufficient conditions for the existence and uniqueness of monotone increasing (decreasing) traveling wave solutions are established. Some faults in previous studies are corrected.
Legendre polynomial expansion of the potential of a uniformly charged disk
Creators: name: Franklin, Jerrold
Publisher: name: arXiv
Year: 2025
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We use a Legendre polynomial expansion to find the electrostatic potential of a uniformly charged disk. We then use the potential to find the electric field of the disk.
description: Accepted for publication in European Journal of Physics
title: Polypharmazie in einer psychiatrischen lnstitutsambulanz
Creators: name: Brüggemann, Bernd
name: Elgeti, Hermann
name: Ziegenbein, Marc
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2008
Subjects: subject: 610

description: Psychopharmakotherapie, vol. 15, no. 2
Assessment of potential for masking in marine mammals of the Antarctic exposed to underwater sound from airguns
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: subject: Antarctic
subject: aerodynamic noise
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters
subject: Lärm
subject: Transport

description: Functional marine mammal acoustic communication evolved under natural ambient noise levels, which makes communication vulnerable to anthropogenic noise sources. In this report, we consider the potential long-range effects ofairgunnoise on marine mammal communication range. During the propagation process, airgun impulses are reflected multiple times from the sea surface, refracted in sound channels and reverberated, leading to signal stretching that may result in a continuous received sound.
Quelle: www.umweltbundesamt.de

description: Functional marine mammal acoustic communication evolved under natural ambient noise levels, which makes communication vulnerable to anthropogenic noise sources. In this report, we consider the potential long-range effects of airgun noise on marine mammal communication range. During the propagation process, airgun impulses are reflected multiple times from the sea surface, refracted in sound channels and reverberated, leading to signal stretching that may result in a continuous received sound.
Normal Factor Graphs
Creators: name: Al-Bashabsheh, Ali
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Holographic transformations
sum of products
partition function
probabilistic models
graphical models
factor graphs
trace diagrams

description: This thesis introduces normal factor graphs under a new semantics, namely, the exterior function semantics. Initially, this work was motivated by two distinct lines of research. One line is ``holographic algorithms,'' a powerful approach introduced by Valiant for solving various counting problems in computer science; the other is ``normal graphs,'' an elegant framework proposed by Forney for representing codes defined on graphs. The nonrestrictive normality constraint enables the notion of holographic transformations for normal factor graphs. We establish a theorem, called the generalized Holant theorem, which relates a normal factor graph to its holographic transformation. We show that the generalized Holant theorem on one hand underlies the principle of holographic algorithms, and on the other reduces to a general duality theorem for normal factor graphs, a special case of which was first proved by Forney. As an application beyond Forney's duality, we show that the normal factor graphs duality facilitates the approximation of the partition function for the two-dimensional nearest-neighbor Potts model. In the course of our development, we formalize a new semantics for normal factor graphs, which highlights various linear algebraic properties that enables the use of normal factor graphs as a linear algebraic tool. Indeed, we demonstrate the ability of normal factor graphs to encode several concepts from linear algebra and present normal factor graphs as a generalization of ``trace diagrams.'' We illustrate, with examples, the workings of this framework and how several identities from linear algebra may be obtained using a simple graphical manipulation procedure called ``vertex merging/splitting.'' We also discuss translation association schemes with the aid of normal factor graphs, which we believe provides a simple approach to understanding the subject. Further, under the new semantics, normal factor graphs provide a probabilistic model that unifies several graphical models such as factor graphs, convolutional factor graphs, and cumulative distribution networks.
The Identification and Characterization of Stem/Progenitor Cells in the Ovarian Surface Epithelium
Creators: name: Turchet, Lisa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013

description: When a follicle ovulates, the ovarian surface epithelium (OSE), which covers the surface of the ovary, is ruptured and then rapidly regenerates. Because of this cycle of wound and repair, we determined if the OSE contains a stem/progenitor cell population. We identified a population of OSE cells with progenitor cell characteristics that express the stem cell marker Stem Cell Antigen-1 (SCA-1). We determined the size of the SCA-1 expressing (SCA-1+) progenitor cell population is regulated by at least two ovulation associated factors present in the follicular fluid: Transforming Growth Factor beta 1 (TGFB1) and Leukaemia-Inhibitory Factor. Ovulation triggers an epithelial-to mesenchymal transition (EMT) in the OSE surrounding the ovulatory wound. Because TGFB1 is a known inducer of the EMT, and because the EMT plays a role in expanding stem cell populations in other epithelia, we determined if TGFB1 expands the SCA-1+ OSE progenitor cell population by triggering an EMT. Treatment with TGFB1 and overexpression of the EMT master gene, SNAIL, caused the OSE cells to undergo an EMT, but unlike TGFB1 treatment, SNAIL overexpression did not expand the SCA-1+ OSE population. Interestingly, EMT induced by SNAIL overexpression increased sphere formation by OSE cells, which indicated that it increased specific stem cell capabilities of the OSE. Because BRCA1 controls the size of the progenitor cell population in mammary epithelium, we determined if the OSE progenitor cell population is regulated by BRCA1. OSE with inactivated Brca1 were more stem-like and expressed higher mRNA levels of the known stem cell markers CD44, CD117, CD133 and Sca-1 compared to OSE with functional Brca1. Inactivation of Brca1 also increased the number of OSE cells with surface expression of SCA-1. In addition, TGFB1 and SNAIL-overexpression decreased BRCA1 protein expression compared to controls. Besides providing the first report of a surface maker for OSE with stem-like properties, the results suggest that these cells may play a role in ovulatory wound healing as they are regulated by the EMT, and in ovarian cancer initiation as their numbers increase when BRCA1 is dysfunctional.
Repair of Aluminum Alloy Aerospace Components and Cold Gas Dynamic Spray Flow Distribution Study
Creators: name: Nastic, Aleksandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Cold Gas Dynamic Spray
Additive Manufacturing
Threads Repair
Substrate Roughness
Pure Aluminum
Al 2024 Alloy
Al 7075 Alloy
Nozzle Material
Particle In-Flight Properties

description: Aluminum alloys have been used for decades in aircraft as they offer a wide range of properties explicitly developed to provide a set of characteristics adapted to structural and non-structural components. However, aircraft components inevitably undergo degradation during service due to their extensive use and exposure to harsh environments. Typical repair methods are either not efficient for large scale repairs due to their low material growth rate, not suitable for field repair or involve the use of high process temperatures. The present research aims at evaluating the cold gas dynamic spray (CGDS) as a potential repair technology to restore Al7075-T6 nose landing gear steering actuator threads found on the Boeing 757 aircraft. Moreover, it studies the suitability of using cold spray to deposit Al2024 material. The influence of process parameters and substrate surface preparation on the material deposition efficiency and resulting microstructural and mechanical repair properties is also evaluated.
Abundance of Non-Polarized Lung Macrophages with Poor Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)
Creators: name: Akata, Kentaro
name: Yamasaki, Kei
name: Leitao Filho, Fernando Sergio
name: Yang, Chen Xi
name: Takiguchi, Hiroto
name: Sahin, Basak
name: Whalen, Beth A.
name: Yang, Cheng Wei Tony
name: Leung, Janice M.
name: Sin, Don D.
name: Van Eeden, Stephanus Frederick
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Lung macrophages are the key immune effector cells in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Several studies have shown an increase in their numbers in bronchoalveolar lavage fluid (BAL) of subjects with COPD compared to controls, suggesting a pathogenic role in disease initiation and progression. Although reduced lung macrophage phagocytic ability has been previously shown in COPD, the relationship between lung macrophages’ phenotypic characteristics and functional properties in COPD is still unclear. (1) Methods: Macrophages harvested from bronchoalveolar lavage (BAL) fluid of subjects with and without COPD (GOLD grades, I–III) were immuno-phenotyped, and their function and gene expression profiles were assessed using targeted assays. (2) Results: BAL macrophages from 18 COPD and 10 (non-COPD) control subjects were evaluated. The majority of macrophages from COPD subjects were non-polarized (negative for both M1 and M2 markers; 77.9%) in contrast to controls (23.9%; p < 0.001). The percentages of these non-polarized macrophages strongly correlated with the severity of COPD (p = 0.006) and current smoking status (p = 0.008). Non-polarized macrophages demonstrated poor phagocytic function in both the control (p = 0.02) and COPD (p < 0.001) subjects. Non-polarized macrophages demonstrated impaired ability to phagocytose Staphylococcus aureus (p < 0.001). They also demonstrated reduced gene expression for CD163, CD40, CCL13 and C1QA&B, which are involved in pathogen recognition and processing and showed an increased gene expression for CXCR4, RAF1, amphiregulin and MAP3K5, which are all involved in promoting the inflammatory response. (3) Conclusions: COPD is associated with an abundance of non-polarized airway macrophages that is related to the severity of COPD. These non-polarized macrophages are predominantly responsible for the poor phagocytic capacity of lung macrophages in COPD, having reduced capacity for pathogen recognition and processing. This could be a key risk factor for COPD exacerbation and could contribute to disease progression.
Evaluating Social Marketing Sponsorships: an analysis of Coca-Cola Canada and ParticipACTION
Creators: name: Bagramian, Ruben
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Social Marketing
Sponsorship
Evaluation

description: Numerous not-for-profit organizations are developing and implementing social marketing programs that aim to address important social issues. Sponsorship has become an important tool to obtain necessary funds to run these programs. However, in today’s competitive environment, organizations have to compete for very limited sponsorship opportunities. To maintain and improve sponsorship relationships, organizations need to be able to evaluate sponsorships using efficient, proven methods. Thus, evaluation of social marketing sponsorship becomes an important component for both scholars and practitioners. However, this area still remains largely under-researched, especially in an empirical setting. This thesis fills this gap by evaluating Coca-Cola Canada sponsorship of the ParticipACTION Teen Challenge program. The results indicate that partners in sponsorship have successfully achieved their shared social marketing objectives by collaborating positively in delivering the program and by creating opportunities for participants to benefit from the program. The research highlights main factors that impact effective sponsorship implementation and evaluation.
Angular momentum and geometrical phases in tight-focused circularly polarized plane waves
Creators: name: Bomzon, Ze'ev
name: Gu, Min
name: Shamir, Joseph
Publisher: name: Swinburne
Year: 2024

description: Calculations for the field at the focal plane of a high numerical aperture lens focusing a circularly polarized plane wave are presented. The calculations show that the polarization of the wave front in the focal plane is space varying, and that a geometrical phase is added to the wave front. Calculation of the angular momentum at the focal plane reveals that it depends on the numerical aperture of the lens. It is shown that this dependence is directly connected to the lens acting as a spatial filter.
What is so crucial about growth, that makes it so indispensable to society despite its impossibility?
Creators: name: Tsilla Boisselet
Publisher: name: Zenodo
Year: 2020
Subjects: wardley mapping, growth, sustainability

description: A mapping exercise on why growth remains a core slogan - Is it possible to map strategic ways out? How to lay down the underlying logic and dependencies and discuss about strategy in a visual way? This is a transparent sharing of some of my reflections so far. I by no means believe I am providing any definitive answer hereby. I would instead invite an open conversation, so that together we could grow ever closer to a shared, affordable and sustainable, path forward.
Wave Blocking Phenomena and Ecological Applications
Creators: name: Dowdall, James
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Wave Blocking
Propagation Failure
Travelling Waves
Reaction Diffusion Equations
Allee Effects
Habitat Fragmentation

description: The growing flow of people and goods around the globe has allowed new, non-native species to establish and spread in already fragile ecosystems. The introduction of invasive species can have a detrimental impact on the already established species. Thus, it is important that we understand the mechanisms that facilitate or prevent invasion. Since reaction-diffusion invasion models produce travelling waves we can study invasion by looking at the mechanisms that allow for wave propagation failure, or wave-blocking. In this thesis we consider a perturbed reaction-diffusion model in which the perturbation resides in either the reaction or diffusion term. In doing so we exploit the underlying symmetry of our problem to define a region in the appropriate parameter space that leads to wave blocking. As a demonstrative example we apply our theory to the bistable equation and consider the effects of various perturbations.
Supplementary document for High performance SERS boosting by Fabry-Perot cavity of silica-gold-silicon multilayers - 7264567.pdf
Creators: name: Li, Zhipeng
name: Zhang, Meng
name: Zhou, Yixi
name: li, pan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplemental
Water maser motions in W3(OH) and a determination of its distance
Creators: name: Hachisuka, Kazuya
name: Brunthaler, Andreas
name: Menten, Karl M.
name: Reid, M. Jamila
name: Imai, Hiroshi
name: Hagiwara, Yoshiaki
name: Miyoshi, Makoto
name: Horiuchi, Shinji
name: Sasao, Tetsuo
Publisher: name: Swinburne
Year: 2024

description: We report phase-referencing VLBA observations of H2O masers near the star-forming region W3(OH) to measure their parallax and absolute proper motions. The measured annual parallax is 0.489 ±0.017 mas (2.04 ±0.07 kpc), where the error is dominated by a systematic atmospheric contribution. This distance is consistent with photometric distances from previous observations and with the distance determined from CH3OH maser astrometry presented in a related paper. We also find that the source driving the H2O outflow, the 'TW-object,' moves with a three-dimensional velocity of >7 km s-1 relative to the ultracompact H II region W3(OH).
Towards a Continuous User Authentication Using Haptic Information
Creators: name: Alsulaiman, Fawaz Abdulaziz A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: User Authentication
Identity Verification
User Identification
Haptics
Genetic Programming
Haptic-enabled Interpersonal Communication System

description: With the advancement in multimedia systems and the increased interest in haptics to be used in interpersonal communication systems, where users can see, show, hear, tell, touch and be touched, mouse and keyboard are no longer dominant input devices. Touch, speech and vision will soon be the main methods of human computer interaction. Moreover, as interpersonal communication usage increases, the need for securing user authentication grows. In this research, we examine a user's identification and verification based on haptic information. We divide our research into three main steps. The first step is to examine a pre-defined task, namely a handwritten signature with haptic information. The user target in this task is to mimic the legitimate signature in order to be verified. As a second step, we consider the user's identification and verification based on user drawings. The user target is predefined, however there are no restrictions imposed on the order or on the level of details required for the drawing. Lastly, we examine the feasibility and possibility of distinguishing users based on their haptic interaction through an interpersonal communication system. In this third step, there are no restrictions on user movements, however a free movement to touch the remote party is expected. In order to achieve our goal, many classification and feature reduction techniques have been discovered and some new ones were proposed. Moreover, in this work we utilize evolutionary computing in user verification and identification. Analysis of haptic features and their significance on distinguishing users is hence examined. The results show a utilization of visual features by Genetic Programming (GP) towards identity verification, with a probability equal to 50% while the remaining haptic features were utilized with a probability of approximately 50%. Moreover, with a handwritten signature application, a verification success rate of 97.93% with False Acceptance Rate (FAR) of 1.28% and @11.54% False Rejection Rate (FRR) is achieved with the utilization of genetic programming enhanced with the random over sampled data set. In addition, with a totally free user movement in a haptic-enabled interpersonal communication system, an identification success rate of 83.3% is achieved when random forest classifier is utilized.
Assisted injection within supervised injection services : Uptake and client characteristics among people who require help injecting in a Canadian setting
Creators: name: Kennedy, Mary Clare
name: Milloy, M-J
name: Hayashi, Kanna
name: Holliday, Elizabeth
name: Wood, Evan
name: Kerr, Thomas
Publisher: name: Elsevier
Year: 2022

description: Background: People who require help injecting illicit drugs experience elevated rates of a range of health-related harms, including overdose and acquisition of blood-borne pathogens. In response, some supervised injection services (SIS) in Canada have begun to permit clients to be physically injected by fellow clients or staff members. However, little is known about uptake and characteristics of clients who engage in this practice. We therefore sought to examine factors associated with receiving injection assistance at SIS among people who require help injecting drugs in Vancouver, Canada. Methods: Data were drawn from two community-recruited prospective cohort studies of people who inject drugs (PWID). We used multivariable generalized estimating equation (GEE) analyses with time-updated covariates to identify factors associated with self-reported receipt of injection assistance at SIS. Results: Between June 2017 and December 2018, 319 individuals who reported having recently required help injecting were included in the study. Of these, 160 (51.0%) were women and the median age was 42 years at baseline. In total, 54 (16.9%) participants reported receiving injection assistance at a SIS at least once over an average of 3.3 months of follow-up. In multivariable GEE analyses, recent homelessness (Adjusted Odds Ratio [AOR] = 2.04; 95% confidence interval [CI]: 1.13 – 3.66), fentanyl injection (AOR = 3.45; 95% CI: 1.42 – 8.41), non-fatal overdose (AOR = 1.86; 95% CI: 1.02 – 3.38) and enrolment in methadone maintenance therapy (AOR = 1.89; 95% CI: 1.03 – 3.47) were associated with increased odds of receiving injection assistance at SIS. Conclusion: Although uptake of assisted injection at SIS was relatively low among this sample of people who require help injecting, this practice was associated with several indicators of structural vulnerability and drug-related risk. These findings suggest that accommodating assisted injection within SIS may be providing opportunities to engage and reduce harms among higher-risk subpopulations of PWID in this setting.
Comprehensive Model of G Protein-coupled Receptor Regulation by Protein Kinase C: Insight from Dopamine D1 and D5 Receptor Studies.
Creators: name: Plouffe, Bianca
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: dopamine
protein kinase C
D1-like dopaminergic receptors
D1 receptor
D5 receptor
desensitization
sensitization

description: Dopamine receptors belong to the G protein-coupled receptor (GPCR) superfamily and are classified into two families: D1-like (D1R and D5R) and D2-like (D2R, D3R and D4R), based on their ability to stimulate or inhibit adenylyl cyclase (AC). Classically, GPCRs (including D2R and D3R) are desensitized by the activation of the serine/threonine protein kinase C (PKC) upon phorbol-12-myristate-13-acetate (PMA) treatment. Previous studies demonstrate that while human D5R (hD5R) is also strongly desensitized upon PMA treatment, the human D1R (hD1R) undergo a robust PMA-induced sensitization. The aim of this PhD thesis was to explore how the canonical PKC- or phorbol ester-linked pathway can control the responsiveness of two similar GPCRs like hD1R and hD5R in an opposite fashion. Our data indicate that hD1R sensitization and hD5R desensitization are not mediated by a direct modulation of AC activity by PKC. Using a chimeric approach, we identified the third intracellular loop (IL3) as the key structural determinant controlling in an opposite manner the PMA-mediated regulation of hD1R and hD5R. To delineate the potential PKC phosphorylation sites, a series of mutation of serine (Ser) and threonine (Thr) located into IL3 of hD1R and hD5R were used. No hD1R mutation decreased the PMA-mediated sensitization. This suggests that hD1R phosphorylation is not required for PMA-induced sensitization. In contrast, our results indicate that PMA-mediated hD5R desensitization occurs through a hierarchical phosphorylation of Ser260, Ser261, Ser271 and Ser274. Notably, these hD5R mutants exhibited a PMA-induced sensitization, reminiscent of the PMA-induced hD1R sensitization. Additionally, using short hairpin RNAs (shRNAs), we showed that PKCε is the potentiating PKC while the desensitizing isoform is δ. Overall, our work suggests the presence or absence of specific Ser residues on IL3 of hD1-like receptors dictate if phosphorylation-dependent desensitization (through PKCδ) or phosphorylation-independent potentiation (via PKCε) will occur.
Supplementary document for Tin reduction from fluorine doped tin oxide for silicon nanowire-based solar energy harvesting and storage - 5410921.pdf
Creators: name: Halagacka, Lukas
name: Gelnarova, Zuzana
name: Al-Ghzaiwat, Mutaz
name: Ileana, Florea
name: Hornice, Jiri
name: Postava, Kamil
name: Foldyna, Martin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement1 - Demonstration of the developed model on sample from alternative manufacturer.
title: Selected Projects in Costume Design
Creators: name: Eagan, Michael
Publisher: name: Utah State University
Year: 1979

description: In his play Picnic, William Inge has created a study in male and female roles--or rather, the roles and types which society forces on them, and which they more frequently force on themselves. The people in this play are not conscious of their roles as roles. There is no free spirit portrayed in the attempt to throw off his or her classification. Even Madge, with her dreams of escape from the confines of small-town life, is acting in accordance with the behavior patterns of her particular genus. This play does not attack the male and female character typing which it portrays, but merely examines it through several personal interactions. As must be expected when seeking to deal with characters as types, Inge at times comes close to stereotyping his people.
Fiscalité et environnement
Creators: name: Vedrine, Claire
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: droit européen
droit fiscal
protection de l'environnement
relations fiscales intergouvernementales

description: La fiscalité environnementale repose sur un double fondement : économique (le double dividende) et juridique (le principe pollueur payeur). Elle doit s’inscrire dans une réforme fiscale verte alliant flexibilité de l’instrument fiscal et pérennité des objectifs environnementaux. Dès lors, la responsabilité environnementale et sociale apparaît comme un nouveau paradigme. Cependant, face à l’internationalisation des problèmes environnementaux et de la concurrence fiscale, l’échelon régional est particulièrement approprié. Au sein même de l’Union européenne, différents scénarios sont possibles. L’ajustement des taxes aux frontières est ainsi un mécanisme efficace de reconnaissance des préoccupations environnementales. L’analyse de la fiscalité environnementale dans différents États, y compris des États en développement, permet d’en apprécier toutes les potentialités. Sans parler de fiscalité mondiale, l'usage des conventions fiscales internationales ou la reconnaissance d'une coutume internationale sont des hypothèses.