LDL Susceptibility to copper-induced oxidation after administration of a single dose of free or esterified beta-cryptoxanthin
Creators: name: Wolters, Maike
name: Hahn, Andreas
Publisher: name: Basel : S. Karger AG
Year: 2004
Subjects: subject: Beta-cryptoxanthin
subject: Beta-cryptoxanthin ester
subject: Low-density lipoprotein
subject: Low-density lipoprotein oxidation
subject: beta cryptoxanthin
subject: cholesterol
subject: copper
subject: cryptoxanthin
subject: ester
subject: low density lipoprotein
subject: oral contraceptive agent
subject: unclassified drug
subject: adult
subject: article
subject: clinical trial
subject: comparative study
subject: controlled clinical trial
subject: controlled study
subject: correlation analysis
subject: drug blood level
subject: drug effect
subject: esterification
subject: female
subject: human
subject: lipid oxidation
subject: male
subject: measurement
subject: normal human
subject: oral contraception
subject: priority journal
subject: randomized controlled trial
subject: smoking
subject: statistical significance
subject: time
subject: Adult
subject: Arteriosclerosis
subject: beta Carotene
subject: Contraceptive Agents, Female
subject: Copper
subject: Esterification
subject: Female
subject: Humans
subject: Lipoproteins, LDL
subject: Male
subject: Oxidation-Reduction
subject: Smoking
subject: Time Factors
subject: Xanthophylls
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Background: The oxidative modification of LDL is believed to be an initial step in atherosclerosis. Thus, antioxidative substances such as carotenoids may have a role in the prevention of coronary heart disease. We examined the susceptibility of LDL to Cu2+ oxidation in young adults before and after a single dose of β-cryptoxanthin. Methods: 1.3 mg of β-cryptoxanthin was administered to 12 apparently healthy young volunteers. Six of the volunteers received esters, the other six free β-cryptoxanthin. The plasma concentration of β-cryptoxanthin and the susceptibility of LDL to copper-induced oxidation ex vivo in terms of the duration of lag time were measured before and 12 h after β-cryptoxanthin ingestion. Results: A single dose of β-cryptoxanthin significantly increased the mean plasma β-cryptoxanthin concentration and the mean cholesterol adjusted β-cryptoxanthin concentration by 117 and 133%, respectively. No effect on the length of lag time was assessed. However, in LDL isolated from plasma 12 h after β-cryptoxanthin administration the lengths of lag time correlated significantly with the plasma β-cryptoxanthin concentration and with the cholesterol adjusted β-cryptoxanthin levels. The lag time did not differ significantly between volunteers who received esters and those who received the same dosage as free β-cryptoxanthin. At both measuring points, smokers, male volunteers and women using oral contraceptives tended to exhibit lower β-cryptoxanthin concentrations and lower cholesterol adjusted β-cryptoxanthin concentrations as well as increased LDL oxidizability compared to nonsmokers and women not using oral contraceptives. Conclusion: A single dose of β-cryptoxanthin does not enhance the duration of LDL lag time ex vivo in healthy young subjects. Copyright © 2004 S. Karger AG, Basel.