Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent
Creators: name: He, Chunyan
name: Corre, Tanguy
name: Mangino, Massimo
name: Uitterlinden, André G.
name: Strachan, David P.
name: Hu, Frank B.
name: Franceschini, Nora
name: Murabito, Joanne M.
name: Cousminer, Diana L.
name: Hunter, David J.
name: Boyd, Heather A.
name: Willemsen, Gonneke
name: Mihailov, Evelin
name: Carola Zillikens, M.
name: Chasman, Daniel I.
name: Rudan, Igor
name: Harris, Tamara B.
name: Hayward, Caroline
name: Yerges-Armstrong, Laura M.
name: Fernández-Rhodes, Lindsay
name: Oostra, Ben
name: Launer, Lenore
name: Buring, Julie E.
name: Montgomery, Grant W.
name: Gudnason, Vilmundur
name: Lin, Peng
name: Widen, Elisabeth
name: Lunetta, Kathryn L.
name: Kraft, Peter
name: Van Duijn, Cornelia M.
name: Elks, Cathy E.
name: Tao, Ran
name: McArdle, Patrick F.
name: Ridker, Paul M.
name: Toniolo, Daniela
name: Byrne, Enda M.
name: Rose, Lynda M.
name: Ong, Ken K.
name: Hofman, Albert
name: Porcu, Eleonora
name: Martin, Nicholas G.
name: Bierut, Laura J.
name: Stöckl, Doris
name: Feenstra, Bjarke
name: Broer, Linda
name: Murray, Anna
name: Zhai, Guangju
name: Rivadeneira, Fernando
name: Lai, Dongbing
name: Warrington, Nicole M.
name: Spector, Tim D.
name: Vollenweider, Peter
name: Poole, Charles
name: Hottenga, Jouke Jan
name: Crisponi, Laura
name: Visser, Jenny A.
name: Wilson, James F.
name: Koller, Daniel L.
name: Perry, John R.B.
name: Dreyfus, Jill G.
name: Polasek, Ozren
name: Pennell, Craig E.
name: Fisher, Sherri L.
name: Boomsma, Dorret I.
name: Kutalik, Zoltán
name: Albrecht, Eva
name: Grallert, Harald
name: Smith, Albert V.
name: North, Kari E.
name: Gieger, Christian
name: Stolk, Lisette
name: Esko, Tõnu
name: Metspalu, Andres
name: Demerath, Ellen W.
name: Hirschhorn, Joel N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)2), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970–2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9–17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.