cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Historic and holocene forest disturbance in South-Central Utah
Creators: name: Morris, Jesse Lee
Publisher: name: University of Utah
Year: 2012
Subjects: Forest disturbance
Holocene
Dendroctonus
Engelmann spruce
Fire
Lake sediments
Picea
Spruce beetle

description: Paleoecological reconstructions provide important information regarding climate affects on vegetation and forest disturbance return intervals. In recent decades, bark beetles (Dendroctonus spp.) have rapidly and profoundly altered subalpine forest ecosystems across interior forests in western North America. Disturbance records for bark beetle epidemics extending beyond the most recent few centuries are absent from the paleoecological literature. The research presented here examines sedimentary pollen records from subalpine lake basins to assess both historic and Holocene disturbance by spruce beetle (D. rufipennis) and wildfire. It is evident that limited vegetative change has occurred over the last 9,000 years and climate is driving fire disturbance regimes rather than forest composition. As insolation-driven seasonal climate extremes ameliorated from the early to the middle Holocene, annual precipitation regimes transitioned from rain- to snow-dominated with perennial lakes developing in south-central Utah. The early Holocene was characterized by high fire peak magnitude and fire frequency, forced by  strong seasonal temperature and moisture contrasts. The middle Holocene was relatively warm, with dry winters and wet summers, facilitating frequent, low-magnitude fire episodes. The late Holocene was relatively cool and wet driven by decreasing summer  insolation and increasing amplitude and frequency of El Niño-Southern Oscillation (ENSO) variability. Landscape-scale stand-replacing fire disturbance becomes essentially absent over the last 3,000 years until the arrival of European settlers to the region. Pollen  ratios from host and nonhost trees assessed during the historic period allow us to infer two high-severity spruce beetle epidemics during the Holocene at ca. 4,000 and 8,200 cal yrs BP.
Sonnenfleckenzeichnung Nr. 22714.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.02.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Dendropaemon (Crassipaemon) lydiae Genier and Arnaud 2016
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dendropaemon
Dendropaemon lydiae

description: § Dendropaemon (Crassipaemon) lydiae Génier and Arnaud, 2016
Dendropaemon (Onthoecus) lydiae Génier and Arnaud 2016: 59 (Brazil)
Distribution. Brazil (NA): Génier and Arnaud 2016: 59 (as Dendropaemon (Onthoecus) lydiae) (NA).
Note. Concerning the location, the labels of the holotype of Dendropaemon lydiae indicate only “Cameta” and “Amazon,” to which the coordinates “(6°10′S, 64°14′W)” were added in Génier and Arnaud (2016: 59). However, those coordinates appear to have been copied from Google Earth, where they point to an otherwise featureless part of the forest labeled “Cametá.” There is no other location with that name in the state of Amazonas, but there is a small city bearing that name in the state of Pará. Although this city is situated along the Rio Tocantins, which technically is not part of the Amazon Basin, it is well possible that the apparent collector, M. de Mathan, who collected extensively in Brazil in the late 19 th and early 20 th century, had used the name “Amazon” to indicate the larger region. This was not unusual at the time, especially because the country name was, like here, often omitted. According to F. Génier (pers. comm. 2016), there is indeed some room for doubt and the actual origin of the holotype might in fact be Cametá in the state of Pará.
Subgenus DENDROPAEMON Perty, 1830
Dendropaemon Perty 1830: 38
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 97, DOI: 10.5281/zenodo.3678492
Maydisone, a novel oxime polyketide from the cultures of Bipolaris maydis
Creators: name: Tran, Thi-Minh-Dinh
name: Nguyen, Van-Kieu
name: Duong, Thuc-Huy
name: Tran, Thanh-Nha
name: Nguyen, Ngoc-Hong
name: Devi, Asshaima Paramita
name: Chavasiri, Warinthorn
name: Dinh, Minh-Hiep
name: Tran, Nguyen-Minh-An
name: Sichaem, Jirapast
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Plant Biology

description: A novel oxime polyketide, maydisone (1), along with two known compounds, 7-hydroxy-2,5-dimethylchromone (2) and 2,5-dimethylbenzoic acid (3) were isolated from the cultures of Bipolaris maydis. Their structures were identified by the application of NMR and MS data analyses and comparison with previous reports. Compound 1 showed the most powerful inhibition of α-glucosidase, with an IC50 value of 68.30 ± 0.83 µM.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.01.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Major Uses of Land and Water In The United States, With Special Reference to Agriculture: Summary for 1959
Creators: name: Wooten, Hugh H.
name: Gertel, Karl
name: Pendleton, William C.
name: Wooten, Hugh H.
name: Gertel, Karl
name: Pendleton, William C.
Publisher: name: Unknown
Year: 1962
Subjects: Land Economics/Use

description: Excerpt from report summary: Planted acreage in 1961 was the smallest since 1930, a peak year for total cropland acreage. Total acreage planted in 1961, including fruits, nuts, and vegetables, was 324 million acres, a reduction of one-eighth from 1930. The biggest reduction since 1930 in acreage has been in grains and cotton. The net difference in total cropland acreage in 1930 and 1961 for the country as a whole does not fully reflect shifts within States and counties. Farming methods together with improved land and water-use have increased production per acre, so that a much smaller cropland acreage can meet the 1962 demand for farm products. The shift in farm power since 1930 from horses and mules to tractors and trucks alone has released about 60 million acres of cropland, formerly used for feed, to other purposes.
Role of physical and chemical properties on gas transfer and blood compatibility of urethane membranes
Creators: name: Knight, Patricia Marie
Publisher: name: University of Utah
Year: 2012
Subjects: Thrombogenicity
Cell Adhesion

description: A major limitation to long-term blood oxygenation is damage to blood elements.  Interposition of a membrane between the gas and blood phases has helped but the thrombogenicity of the membrane material still limits the long-term use of blood oxygenators.  This can result in microemboli, local thrombosis, degradation of gas transfer or the loss of certain blood elements such as platelets.  Some copolyurethanes have been reported to have improved blood compatibility.  This study was undertaken to explore the use of these new material for blood oxygenation.  This involved the determination of the gas permeability coefficients of the copolyurethane materials.  Also, the effects of molecular structure and fabrication variables on the gas permeability coefficients were studied.  From these studies, it became apparent that to provide adequate gas transfrer, the copolyurethanes would have to be fabricated very thin or microporous.  Thus, porous copolyurethane films were cast onto porous supports and their gas fluxes and surface compatibility assessed with flowing blood in a system simulating and artificial lung.  Comparisons were made with presently used membrane materials including silicone rubber, Goretex®  and Celgard®.  The gas transfer of the porous copolyether urethane membranes was found to depend on the substrate used and the polymer coating thickness.  When the thickness of the polymer coating was kept in the 3 to 5 µm range, gas transfer was adequate for blood oxygenation.  The copolyurethane membrances were observed to have good blood compatibility as oxygenator membranes in that they absorbed fewer blood elements and had very few clots compared to the other material tested.  This may be related to the finding that these materials absorbed more albumin and less fibrinogen than the other materials.
Dendropaemon (Dendropaemon) aenigmaticus Genier and Arnaud 2016
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dendropaemon
Dendropaemon aenigmaticus

description: Dendropaemon (Dendropaemon) aenigmaticus Génier and Arnaud, 2016
Dendropaemon (Dendropaemon) aenigmaticus Génier and Arnaud 2016: 24 (French Guiana)
Distribution. French Guiana: Génier and Arnaud 2016: 24; Boilly et al. 2016: 94.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 97, DOI: 10.5281/zenodo.3678492
Additional file 5 of Fake anabolic androgenic steroids on the black market – a systematic review and meta-analysis on qualitative and quantitative analytical results found within the literature
Creators: name: Magnolini, Raphael
name: Falcato, Luis
name: Cremonesi, Alessio
name: Schori, Dominique
name: Bruggmann, Philip
Publisher: name: figshare
Year: 2022
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5. Supplementary analyses.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.02.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
In vitro progesterone metabolism by avian testicular tissue
Creators: name: Fevold, Harry Richard
Publisher: name: University of Utah
Year: 2012
Subjects: Progesterone

description: It has been shown by in vitro incubations that  cell-free homogenates of testicular tissue from the English sparrow (Passer domesticus) are capable of synthesizing androgenic steroid hormones for 4-pregnen-3,20-dione-4-C14 by a pathway involving 17?-hydroxylation, cleavage of carbons 20 and 21 to form 4-androstein-2, 17-dione, and reduction of the 17-ketone to form 4-androsten-17?-ol-3-one.  The only exogenous cofactor required for this sequence of reactions in reduced triphosphopyridinenucleotide.  In addition, both 4-pregnen-3, 20-dione, and 4-pregnen-17?-ol-3, 20-dione are reduced at the 20-ketone to form 4-pregnen-20?-ol-3-one, 4-pregnen-20?-ol-3-one, 4-Pregnen-17?, 20?-diol-3-one, and 4-pregnen-17?, 20?-diol-3-one.  Two other products of progesterone metabolism believed to be 4-pregnen-20?-ol-3-one and 4-pregnen-20?-ol-3-one with a second hydroxyl at a position in the steroid nucleus have been incompletely identified.  The variation of the testicular content of the 17?-hydroxylase and the two progesterone-20-ketone reductases over a wide range of natural and artificial testicular stimulation was determined.  It was found that on a milligram of protein basis the 17?-hydroxylase decreased by a factor of 10 with an increase in testis weight from 7.2 to 480 milligrams,  whereas the 20-ketone reductases remained relatively constant or decreased to a musch lesser extent, by a factor of two, over similar testicular weight changes.  Calculated on the basis of enzyme content per bird by use of an average combined testicular weight, the total testicular 17?-hydroxylase increased by a factor of three to four, while the 20-ketone reductases increased by a factor of twenty to forty when the mean testicular weight increased from 7.2 to ca. 500 milligrams.  Artificial testicular simulation with human chorionic gonadotropin stimulation both the 17?-hydroxylase and 20-ketone reductases, but appeared to have greater effect on the 17?-hydroxylase.
Sonnenfleckenzeichnung Nr. 22701.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.01.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Converting an Oncogenic Protein into an Apoptotic Factor: Targeting BCR-ABL to the Mitochondria
Creators: name: Constance, Jonathan Eric
Publisher: name: University of Utah
Year: 2014
Subjects: Leukemia - Treatment - Molecular aspects
Leukemia - Genetic aspects
Mitochondrial pathology

description: The advent of rational drug design to target a single molecular event, as so aptly demonstrated with tyrosine kinase inhibitor (TKI) therapy and Bcr-Abl, has set a precedent for the ability to attack malignancy directly at the level of the oncogenic event. However, in the last decade it has become clear that new therapeutic strategies for chronic myelogenous leukemia (CML) must move beyond the mere inhibition of Bcr-Abl's tyrosine kinase activity if a cure is to be found. TKI resistance, persistent leukemic stem cells, and the acute blast phase crisis remain major problems to be solved. This work describes the efforts to use the central leukemogenic protein of CML, Bcr-Abl (oncogenic event itself), to selectively destroy the diseased cells that harbor it. The subcellular localization of Bcr-Abl determines its function. This is also true for Bcr-Abl's normal counterpart, c-Abl. When localized to the mitochondria, c-Abl is a potent inducer of cell death. However, c-Abl pro-death activity is disrupted in CML. The mitochondriolytic mechanism of ‘death-directed' c-Abl is unknown. Yet, under conditions of cell stress from a variety of sources (e.g., endoplasmic reticulum stress, genotoxic agents, and oxidative stress) active c-Abl migrates to the mitochondria causing dysfunction and cell death. Our direct targeting of c-Abl and Bcr-Abl to the mitochondria demonstrated the sufficiency of c-Abl alone to kill leukemia cells and of Bcr-Abl's ability to recapitulate this function. iv The central hypothesis of this study is that forcing Bcr-Abl to the mitochondria will selectively induce the death of leukemic cells by converting Bcr-Abl into an apoptotic factor. This approach restores a defunct apoptotic pathway (i.e., the mitochondrial ‘death-directed' c-Abl pathway) and does not rely on the indirect engagement of (often dysregulated) cell death mechanisms like many chemotherapeutics. c-Abl requires a mitochondrial chaperone (protein kinase Cδ). Therefore, we designed a protein chaperone, the intracellular cryptic escort (iCE), for Bcr-Abl that selectively functions in the pro-oxidative environment of CML cells. Though, the iCE did not move Bcr-Abl to the mitochondria, it did synergistically and selectively kill CML cells as a combination with imatinib or alone was as toxic as high dose imatinib.
A new steroidal glycoside from the fruits of Solanum myriacanthum
Creators: name: Ono, Masateru
name: Shimode, Mizuki
name: Tsutsumi, Shuhei
name: Yasuda, Shin
name: Okawa, Masafumi
name: Kinjo, Junei
name: Miyashita, Hiroyuki
name: Ikeda, Tsuyoshi
name: Yoshimitsu, Hitoshi
name: Nohara, Toshihiro
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: A new cholestane-type steroidal glycoside, solamyriaside A (1), was isolated from the fruits of Solanum myriacanthum Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A (2) and aculeatiside A (3), and three known steroidal alkaloid glycosides, namely, solamargine (4), khasianine (5) and solasonine (6), which were isolated for the first time from this plant. Based on spectroscopic data as well as chemical evidence, 1 was determined to be 3-O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl-22R,25R-cholest-5-ene-3β,16α,22,26-tetraol 26-O-β-D-glucopyranoside. The cytotoxic activity of 1–6 against HL-60 human promyelocytic leukaemia cells was examined. Compounds 4–6 showed cytotoxic activity. Among them, 4 exhibited the strongest activity with an IC50 value of 4.64 ± 0.17 μM, similar to the activity of cisplatin, a positive control.
Sonnenfleckenzeichnung Nr. 22694.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.01.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 1 of Empowerment resources, decision-making and gender attitudes: which matter most to livestock keepers in the mixed and livestock-based systems in Ethiopia?
Creators: name: Kinati, Wole
name: Baker, Derek
name: Temple, Elizabeth C.
name: Najjar, Dina
name: Mulema, Annet Abenakyo
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. Ranking empowerment resources among livestock keepers, Men FGD, Boqa kebele, and Adiyo woreda. Table S2. Ranking empowerment resources among livestock keepers, Women FGD, Shuta kebele, and Adiyo woreda. Table S3. Ranking empowerment resources among livestock keepers, Women FGD, Hidi Dale kebele, and Elweya woreda. Table S4. Ranking empowerment resources among livestock keepers, Men FGD, Adegalchet kebele, and Elweya woreda. Table S5. Ranking empowerment resources among livestock keepers, Men FGD, Gitilo Dale kebele, Horo woreda. Table S6. Ranking empowerment resources among livestock keepers, Men FGD, Leku Igu kebele, Horo woreda. Table S7. Ranking decisions for key HH resources, Women FGD, Boqa kebele, and Adiyo woreda. Table S8. Ranking decisions for key HH resources, Men FGD, Shuta kebele, and Adiyo woreda. Table S9. Ranking decisions for key HH resources, Women FGD, Adegalchet kebele, Elweya woreda. Table S10. Ranking decisions for key HH resources, Men FGD, Hidi Dale kebele, Elweya woreda. Table S11. Ranking decisions for key HH resources, Men FGD, Gitilo dale kebele, Horo woreda. Table S12. Ranking decisions for key HH resources, Men FGD, Leku Igu kebele, Horo woreda
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.01.1968, erstellt als erste Tagesaufnahme um 8 h 45 von Gisèle Evrard-Kesteloot, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.02.1968, erstellt als zweite Tagesaufnahme um 12 h 05 von André Koeckelenbergh, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Characterization of free and insoluble-bound phenolics of chia (Salvia hispanica L.) seeds
Creators: name: Mitrović, Jelena
name: Nikolić, Nada
name: Karabegović, Ivana
name: Lazić, Miodrag
name: Stojanović, Gordana
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: The content, antioxidant activity and composition of free and bound phenolics from chia seeds were investigated. The free phenolics were extracted by using ethanol and methanol of analytical purity, 70% v/v ethanol and by 70% v/v methanol. The bound phenolics were extracted from seeds after alkaline hydrolysis was done. The phenolics content obtained by aqueous-alcoholic solutions was higher than the content obtained by using the pure alcoholic solution (for 20.8% by 70% methanol and 41.2% by 70% ethanol). The content of bound phenolics was 932 μg g−1. Among the identified phenolic compounds the apigenin 4'-O-glucoside was the most abundant, and among the acids, a rosmarinic was the most abundant in free phenolic extract and caffeic acid in bound. The correlation coefficients indicated the DPPH method and reducing power were more suitable for assessing the antioxidant activity than the FRAP method.
Utilising existing data for a pilot social return on investment analysis of the family wellbeing empowerment program: A justification and framework
Creators: name: Nolan, Clare
name: Bridge, Rosie
name: Holland, Grace
name: Whiteside, Mary
name: Baird, Leslie
name: Andrews, Suzanne
name: Hong, Anita Lee
name: Tsey, Komla
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 4504
subject: Aboriginal and Torres Strait Islander health and wellbeing
classificationCode: 4206
subject: Public health
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 44
subject: Human society

description: Demand is growing in the public, private, and philanthropic sectors for economic and quantifiable outcome data to guide decisions regarding the allocation of resources. This paper explores the challenges and opportunities in economically evaluating an Aboriginal Social and Emotional Wellbeing intervention, emphasising the value of utilising existing data. Driven by local and national Indigenous research priorities, the study involved a pilot Social Return on Investment analysis of the Aboriginal Family Wellbeing empowerment program. Underpinned by a collaborative mixed-methods approach, designed to mitigate data limitations and bolster trustworthiness, the analysis was undertaken across four stages, including a literature review to identify impacts and create a theory of change; co-design of an impacts framework; a targeted literature review to inform impact quantification and attribution; and calculation of the Social Return on Investment results. Results indicate that for every Australian dollar of investment in delivering Family Wellbeing between 2001 and 2021 in the Yarrabah Aboriginal community, A$4.60 of benefits were produced for participants and the community. The return is expected to be higher if important community and cultural impacts of the program were included in the monetisation. Data limitations and implications for future mixed methods economic evaluation of social interventions are explored.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.01.1968, als Blatt eröffnet dank auswärtiger Beobachtungen, ausgewertet in Zürich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung bzw. Auswertung aufgrund auswärtiger Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen direkt auf dem Vordruck, erstellt durch Mitarbeitende der Eidgenössischen Sternwarte Zürich
Dendropaemon (Dendropaemon) amazonicus Genier and Arnaud 2016
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dendropaemon
Dendropaemon amazonicus

description: § Dendropaemon (Dendropaemon) amazonicus Génier and Arnaud, 2016
Dendropaemon (Dendropaemon) amazonicus Génier and Arnaud 2016: 25 (Brazil (NA))
Distribution. Brazil (NA): Génier and Arnaud 2016: 25 (NA).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 98, DOI: 10.5281/zenodo.3678492
Limonoids and carbazole alkaloids from the twigs of Chalcas siamensis Tanaka
Creators: name: Boonyaketgoson, Sirada
name: Rukachaisirikul, Vatcharin
name: Phongpaichit, Souwalak
name: Trisuwan, Kongkiat
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: One new limonoid, named siamensinolide (1), together with two known limonoids (2 and 3) and eight carbazole alkaloids (4–11) were isolated from the twigs of Chalcas siamensis Tanaka. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. O-methylclausenolide (2) displayed strong cytotoxicity against A2780 cell lines with the IC50 value of 9.2 µM, while clausenolide (3) exhibited strong antibacterial activity against methicillin-resistant Staphylococcus aureus with the MIC value of 0.5 µg/mL.
Additional file 2 of Sulfate-reducing bioreactors subjected to high sulfate loading rate or acidity: variations in microbial consortia
Creators: name: Salo, Marja
name: Bomberg, Malin
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 2. Additional figures and tables.
Sonnenfleckenzeichnung Nr. 22709.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.02.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
A diagnostic expert system, Iliad, as a quality review screen.
Creators: name: Lau, Lee Min
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Health Care

description: A diagnostic expert system, Iliad, was evaluated as a quality review tool in the Medicare inpatient review performed by Peer Review Organizations (PROs). The current PRO review appeared to underdetect diagnostic errors. The PRO review started with a nurse review using generic quality screens. Only cases flagged by the nurse review as containing a potential quality problem were then referred for a physician review. The quality screens focused only on treatment, discharge and documentation. Physician review, directed by the concerns raised in the nurse review, might also have failed to detect diagnostic errors. Thus, the expert diagnostic capability of Iliad could be useful as a nurse review screen for diagnostic errors. A discrepancy between Iliad's diagnosis and that made by the attending physician for a case would flag a potential diagnostic error. The case could then be referred to a physician for confirmation. Two experiments were performed. The first compared Iliad review with the current PRO review. On 100 Medicare inpatient cases flagged by the Utah Peer Review Organization (UPRO) nurse review as containing potential problems, and which contained diagnoses recognized by Iliad, Iliad review found 17% of the cases to have contained a diagnostic error, significantly higher than the 0% Diagnostic Error Rate (DER) found by UPRO. The Iliad nurse review True Positive Rate (TPR) was also significantly higher than that of the UPRO nurse review. The second experiment compared Iliad review to the computerized UCDS (Unified Clinical Data Set) review undergoing testing at UPRO. In a random sample of 326 Utah Medicare inpatient cases containing diagnoses recognized by Iliad, Iliad review found a significantly higher DER of 6%, compared to that found by the UCDS review (0.8%). The Iliad nurse review TPR was also significantly higher than that of the UCDS nurse review. The effects of varying the 'strictness' of Iliad review, different diagnosis matching strategies, different nurse reviewers, and different physician reviewers were explored. A cost-benefit estimation was also performed. It was concluded that Iliad review was effective and efficient in detecting diagnostic errors causing quality of care problems in Medicare hospitalizations.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.01.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Determinants of cell fate during zebrafish embryogenesis
Creators: name: Helde, Kathryn Ann
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Embryology
subject: Genetics
subject: FOS: Biological sciences

description: The mechanisms underlying how the cells within a vertebrate embryo acquire specific fates are not well understood. From previous studies on zebrafish, two models emerged that describe the cell fate potentials of early cells (blastomeres). In one model, the tissues that will be populated by the descendants of any blastomere cannot be predicted. In the second model, tissue fates are strictly and reproducibly segregated into specific blastomeres by the initial cleavages. The work presented here supports some aspects of each of the above models. I show that in zebrafish, blastomeres do not have predictable prospective tissue fates, and there is no correlation between the position of a blastomere and the specific set of tissues derived from it. However, the position of a blastomere influences two aspects of the cell fates adopted by its descendants. Specifically, the position of a blastomere affects which germ layer the majority of the descendants populate, and affects the number of different tissues the descendants tend to populate. The inability to predict the specific tissues derived from any blastomere is consistent with some aspects of the first model, whereas the tendency for some blastomeres to populate different subsets of tissues is consistent with predictions from the second model. Based on these results, I suggest that if maternally supplied determinants are used to initiate pattern formation in the embryo, there are specific constraints as to where the determinants might be localized. If maternal determinants establish embryonic patterning they must be either localized within the cells that give rise to the marginal region of the gastrula, or sequestered within the yolk cell. In order to determine when and where zebrafish express a putative localized cell fate determinant, I examined the expression of the zebrafish homolog of Xenopus Vg1. Although Vg1 RNA is restricted to vegetal blastomeres in Xenopus, I found that Vg1 RNA is present throughout all blastomeres in zebrafish. This finding is consistent with the idea that although zebrafish blastomeres show tendencies to populate specific subsets of tissues, all blastomeres have equivalent cell fate potentials
SABYDOMA Project: Introducing Feedback Control to Safety by Design of Nanomaterials
Creators: name: Doganis, Philip
name: Nikolakopoulos, Athanassios
name: Kejun Wu
name: Nelson, Andrew
name: Haralambos Sarimveis
Publisher: name: Zenodo
Year: 2020
Subjects: Safety By Design
Computational toxicology
Nanomaterial
Nanosafety

description: In order to achieve safer nanomaterials (NMs), the safety by design (SbD) concept provides a significant advance by acting
 preemptively. Within the SbD concept, it is necessary to define systems and methodologies that ensure both the safety and efficacy
 of the final product. This must be accompanied by managing production effectively, so that out of specification product quantities
 are minimized while workplace exposure to NMs remains within safe limits. An integrated approach that addresses all these issues,
 ranging from control of processes to design of products is needed to address the challenges in the field. The SABYDOMA project aims to apply systems control and optimisation principles in all successive stages of SbD. A groundbreaking
 methodology will introduce for the first time the model predictive control (MPC) philosophy, which is one of the most popular and successful control methodologies in the chemical industry and beyond. A basic ingredient of the proposed MPC approach is the development of mathematical models, which correlate the system inputs with safety-related controlled variables, such as toxicity. The most appropriate modelling methodological approaches will be applied at different levels of SbD. The introduction of Feedback Control to the production and design of Nanomaterials addresses many problems that arise in the field, offering not only mitigation of risk, but also control over the process, bridging functionality and safety.
The Frame-based model of nursing care plans on the HELP system.
Creators: name: Wang, Ping
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Care
subject: Diagnosis
subject: Outcome and Process Assessment (Health Care)
subject: Patient Care Planning

description: The computerized Nursing; care plan is an integral part of HELP Nursing; subsystem.  The frame technology, which is a new architecture for implementing a knowledge driven hospital information system, has been used to computerize the Nursing; care plan on the HELP system. Different methods of data retrieval and storage have been introduced, tested and compared in terms of programming speed and structure.  A general and flexible model called â€œthe frame-based modelâ€ has been developed.  The model is flexible enough to accommodate the change of the Nursing; care plan database and it could be change of the Nursing; care plan database and it could be a general model for other applications on the HELP system.  The model is able to integrate HELP decision support functions sot that the expert knowledge can be used in the automation of the Nursing; care plan.
Dendropaemon (Dendropaemon) angustulus Genier and Arnaud 2016
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dendropaemon
Dendropaemon angustulus

description: Dendropaemon (Dendropaemon) angustulus Génier and Arnaud, 2016
Dendropaemon (Dendropaemon) angustulus Génier and Arnaud 2016: 26 (Venezuela (EO))
Distribution. Guyana: Génier and Arnaud 2016: 26. French Guiana: Génier and Arnaud 2016: 26; Boilly et al. 2016: 94. Brazil (NA): Génier and Arnaud 2016: 26 (NA). Venezuela (EO): Génier and Arnaud 2016: 26 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 98, DOI: 10.5281/zenodo.3678492
Two new norlignans from the aerial parts of Pouzolzia sanguinea (Blume) Merr
Creators: name: Nhung, Le Thi Hong
name: Huong, Pham Thi Mai
name: Anh, Nguyen Tuan
name: Tai, Bui Huu
name: Nhiem, Nguyen Xuan
name: Van Doan, Vu
name: Hoang, Nguyen Huy
name: Seo, Yohan
name: Kim, Seung Hyun
name: Van Kiem, Phan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry

description: Two new norlignans, pouzolignan N (1) and pouzolignan O (2), together with five known norlignans, pouzolignan F (3), pouzolignan G (4), pouzolignan H (5), pouzolignan L (6), and gnetifolin F (7) were isolated from the aerial parts of Pouzolzia sanguinea (Blume) Merr. Their chemical structures were elucidated via HR-ESI-MS and NMR spectroscopic methods. Absolute configurations at stereocenters were confirmed by comparisons of CD spectra with those of TD-DFT calculations. Compounds 1–6 exhibited chemical structures unique to Pouzolzia species. At a concentration of 30 µM, compounds 1–7 exhibited weak cytotoxic activity toward CAL27 and MDA-MB-231 cell lines (cell viability from 65.3 ± 0.86 to 98.8 ± 1.23%). They also inhibited anoctamin-1 activity with inhibitory rates from 8.1 ± 0.87 to 24.3 ± 1.41%.
Analysis of behavioral adjustment changes in heterogenously grouped psychiatric patients
Creators: name: Lindsey, Elizabeth Pinkston
Publisher: name: University of Utah
Year: 2012
Subjects: Psychiatric hospital care

description: This study was designed to analyze the behavioral adjustment changes which occurred in heterogeneously grouped psychiatric patients over a two month time period, The question was asked, is there a therapeutic effect which, as measured on a Behavioral Adjustment Scale, results in more acceptable behavioral responses for both the chronic and overtly psychotic patients as well as the acute and covertly psychotic patients?  Sixty-six patients were equated on age? diagnosis, length of stay in the hospital and the MACC Behavioral Adjustment Rating Scale,  The MACC scale was the instrument for measuring behavioral adjustment. The patients were equally distributed over three wards based upon the three above controls and the first rating on the MACC Scale. Ratings were completed at one  and two month intervals.  The wards operated under a unit organizational system.  Analysis of variance of the changes in adjustment scores indicated:  1. There was no overall improvement for all patients.  2. There was no overall improvement in the above average adjusted patient.  3. There was an improvement after one month in all below average behavioral adjusted patients.  4. There was overall improvement in the below average adjusted patient on only one ward.  It is concluded that: 1. The unit ward system per se did not contribute to the improvement in behavioral adjustment for patients.  2. There was a factor present on one ward and missing from the other two wards which could account for behavioral adjustment improvement.  3. This unidentified factor was specific to improvement in only the below average group.
Sonnenfleckenzeichnung Nr. 22724.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.03.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 1 of Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates
Creators: name: Munro, Matthew J.
name: Wickremesekera, Susrutha K.
name: Tan, Swee T.
name: Peng, Lifeng
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Additional file 1. Patient demographics, pathology and biochemical characteristics.
Role of multidrug resistance P-glycoproteins in cholesterol metabolism
Creators: name: Neklason, Deborah Wood
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolsim
Biochemical
Genetic Mapping

description: Cellular cholesterol homeostasis is maintained by regulated uptake of LDL-derived cholesterol, biosynthesis of cholesterol, and conversion of cholesterol to cholesteryl esters. Intracellular sterol transport between the plasma membrane and the endoplasmic reticulum (ER) is an important aspect of cholesterol esterification and biosynthesis. Progesterone inhibits these processes by blocking the transport of cholesterol and cholesterol precursors to the ER. Recent studies suggest that progesterone acts by inhibiting the activity of one or more of the multidrug resistance (MDR) P-glycoproteins. Structurally different inhibitors of MDR activity were shown to inhibit cholesterol esterification and biosynthesis in cell lines originating from multiple tissue types. A common mechanism requiring MDR activity is likely involved in both cholesterol biosynthesis and esterification. Using biochemical and genetic markers, the steps required for esterification of LDL-derived cholesterol were dissected. MDR inhibitors were shown to block a late step in delivery of cholesterol to the ER. Cells treated with MDR inhibitors also excluded a fluorescent cholesterol analog from the ER and accumulated novel vesicles. MDR inhibitors did not alter the general distribution of cholesterol in the plasma membrane as monitored by HDL-mediated cholesterol efflux. In addition, inhibition of MDR1 activity at the plasma membrane with MRK-16 antibody did not correlate with a decrease in cholesterol esterification or biosynthesis. MDR activity appears to be required for vesicular delivery of cholesterol to the ER after its departure from the plasma membrane. MDR P-glycoproteins catalyze translocation of phospholipids across the membrane bilayer; this activity may be required for vesicle generation or vesicle fusion events. The involvement of MDR P-glycoproteins in two cholesterol related diseases, coronary heart disease (CHD) and Smith-Lemli-Opitz syndrome (SLOS) was investigated. Coinheritance of the MDR genetic locus was analyzed in sibling pairs with CHD. Inherited abnormalities at the MDR genetic locus do not cause CHD, but quantitative trait analysis revealed that they do influence circulating triglyceride levels. Lymphoblasts from three SLOS patients with distinct phenotypes showed normal MDR mediated drug efflux, and normal subcellular localization of cholesterol and 7-dehydrocholesterol, a sterol that accumulates in SLOS patients. Differences in cholesterol biosynthesis that likely result from different mutations in 3?-hydroxysterol-?7-reductase are described.