cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma
Creators: name: Guo, J
name: Liu, Y
name: Gao, Y
name: Liu, Z
name: Wang, M
name: Huang, L
name: Yu, Z
Publisher: name: BioMed Central Ltd
Year: 2022

description: Background: Hepatocellular carcinoma (HCC) developed in fibrotic liver does not respond well to immunotherapy, mainly due to the stromal microenvironment and the fibrosis-related immunosuppressive factors. The characteristic of liver sinusoidal endothelial cells (LSECs) in contributing to fibrosis and orchestrating immune response is responsible for the refractory to targeted therapy or immunotherapy of HCC. We aim to seek a new strategy for HCC treatment based on an old drug simvastatin which shows protecting effect on LSEC. Method: The features of LSECs in mouse fibrotic HCC model and human HCC patients were identified by immunofluorescence and scanning electron microscopy. The effect of simvastatin on LSECs and hepatic stellate cells (HSCs) was examined by immunoblotting, quantitative RT-PCR and RNA-seq. LSEC-targeted delivery of simvastatin was designed using nanotechnology. The anti-HCC effect and toxicity of the nano-drug was evaluated in both intra-hepatic and hemi-splenic inoculated mouse fibrotic HCC model. Results: LSEC capillarization is associated with fibrotic HCC progression and poor survival in both murine HCC model and HCC patients. We further found simvastatin restores the quiescence of activated hepatic stellate cells (aHSCs) via stimulation of KLF2-NO signaling in LSECs, and up-regulates the expression of CXCL16 in LSECs. In intrahepatic inoculated fibrotic HCC mouse model, LSEC-targeted nano-delivery of simvastatin not only alleviates LSEC capillarization to regress the stromal microenvironment, but also recruits natural killer T (NKT) cells through CXCL16 to suppress tumor progression. Together with anti-programmed death-1-ligand-1 (anti-PD-L1) antibody, targeted-delivery of simvastatin achieves an improved therapeutic effect in hemi-splenic inoculated advanced-stage HCC model. Conclusions: These findings reveal an immune-based therapeutic mechanism of simvastatin for remodeling immunosuppressive tumor microenvironment, therefore providing a novel strategy in treating HCC.
sj-pdf-1-pus-10.1177_09636625211002375 – Supplemental material for Masculinity in the public image of physics and mathematics: a new model comparing Japan and England
Creators: name: Ikkatai, Yuko
name: Inoue, Atsushi
name: Minamizaki, Azusa
name: Kano, Kei
name: McKay, Euan
name: Yokoyama, Hiromi M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Science Policy

description: Supplemental material, sj-pdf-1-pus-10.1177_09636625211002375 for Masculinity in the public image of physics and mathematics: a new model comparing Japan and England by Yuko Ikkatai, Atsushi Inoue, Azusa Minamizaki, Kei Kano, Euan McKay and Hiromi M. Yokoyama in Public Understanding of Science
Bridge damage analysis under joint environmental and operational variability
Creators: name: Delgadillo, Rick M.
name: Tenelema, Fernando J.
name: Casas, Joan R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: One of the main challenges for bridge damage identification using monitoring data is to acquire sensitive damage features but insensitive to operational and environmental effects as well as noise. Specifically, the temperature as part of environmental variability can mask structural damages in bridges. Principal Component Analysis (PCA) has been applied here as a well-known and robust technique for removing environmental variability and obtain damage-sensitive indices. As a first aim, PCA is used considering only ambient vibrations and the natural frequencies are considered as damage indicators. As a second objective, PCA in conjunction with Hilbert Huang Transform (HHT) and Variational Mode Decomposition (VMD) are applied to eliminate the environmental influence in transient vibrations due to traffic. The combined methodology is applied to the case of a numerical benchmark by using the Instantaneous Phase Difference (IPD) as novel vibration damage feature in the case of non-stationary vibrations. The results show that the proposed strategy to use the non-stationary vibration due to traffic instead of ambient vibration seems a promising tool for damage identification and, therefore, its capabilities in real bridge applications are worth exploring further when experimental data from real bridges will become available.
An improved method for predicting the shear strength of corroded reinforced concrete beams with experimental and numerical validation
Creators: name: Xue, Xin
name: Cheng, Jian
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Shear failure of reinforced concrete (RC) beams is a brittle failure without giving sufficient warning. Steel bar corrosion is one of the main deterioration phenomena for concrete structures in marine environments. However, the effect of steel bar corrosion on the shear-transfer mechanism of RC beams is not yet fully understood, and existing findings are insufficient for reasoned and accurate prediction of shear strength. Thus, the primary objective of this study was to propose and validate a revised fictitious-support-point method for better predicting the shear strength of corroded RC beams. The revised method determines the fictitious support points based on a more transparent mechanical model than previously. Finite element simulation confirms the validity of the revised method from the load-bearing mechanism point of perspective. Validation with copious previously-published test data show that the revised method predicts the shear strength of corroded RC beams more accurately and reasonably than the existing method proposed by other researchers. This study contributes to effective and reasonable maintenance of corroded RC structures.
sj-pdf-1-erp-10.1177_08902070211001258 - Supplemental material for Neuroticism and satisfaction in romantic relationships: A systematic investigation of intra- and interpersonal processes with a longitudinal approach
Creators: name: Kreuzer, Marianne
name: Gollwitzer, Mario
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-erp-10.1177_08902070211001258 for Neuroticism and satisfaction in romantic relationships: A systematic investigation of intra- and interpersonal processes with a longitudinal approach by Marianne Kreuzer and Mario Gollwitzer in European Journal of Personality
GROVER DNA language model tutorial
Creators: name: Sanabria Melissa
name: Hirsch Jonas
name: Poetsch Anna R
Publisher: name: Zenodo
Year: 2024
Subjects: DNA Language Models
GROVER

description: Tutorial for the use of GROVER as a foundation model for different tasks to interrogate the human genome. More information on the study can be found at https://www.biorxiv.org/content/10.1101/2023.07.19.549677v1. Links in the tutorial point to Google Collab, but are also uploaded at Zenodo.  

Pretrained GROVER can be found at https://doi.org/10.5281/zenodo.8373117.

The tokenised genome (hg19) can be found at https://doi.org/10.5281/zenodo.8373053.
Additional file 1 of miR-6076 rs1463411 polymorphisms are associated with bleeding during clopidogrel treatment in patients with acute coronary syndrome
Creators: name: Mo, Zhen-Zhen
name: Yuan, Zhen
name: Peng, Yuan-Yuan
name: Zhou, Wan-Lu
name: Dai, Wei
name: Wang, Guo
name: Tang, Jie
name: Zhang, Wei
name: Chen, Bi-Lian
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Computational Biology

description: Additional file 1: miRNA, CYP2C19*2, and CYP2C19*3 polymorphisms.
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth
Creators: name: Shen, L
name: Tiruthani, K
name: Song, W
name: Huang, L
name: Lai, S.K
name: Li, J
name: Liu, Q
name: Liu, R
name: Dorosheva, O
name: Zhang, X
name: Das, M
name: Hu, H
Publisher: name: Elsevier B.V.
Year: 2022

description: Interactions between different cell types in the tumor microenvironment (TME) affect tumor growth. Tumor-associated fibroblasts produce C-X-C motif chemokine ligand 13 (CXCL13) which recruits B cells to the TME. B-cells in the TME differentiate into regulatory B cells (Bregs) (IL-10+CD1d+CD5+CD138+CD19+). We highlight these Breg cells as a new important factor in the modulation of the immunosuppressive TME in different desmoplastic murine tumor models. In addition, CXCL13 also stimulates epithelial–mesenchymal transition (EMT) of the tumor cells. The tumorigenic roles of CXCL13 led us to explore an innovative anti-cancer strategy based on delivering plasmid DNA encoding a CXCL13 trap to reduce Bregs differentiation and normalize EMT, thereby suppressing tumor growth. CXCL13 trap suppressed tumor growth in pancreatic cancer, BRAF-mutant melanoma, and triple-negative breast cancer. In this study, following treatment, the affected tumor remained dormant resulting in prolonged progression-free survival of the host.
sj-pdf-9-erp-10.1177_08902070211001258 - Supplemental material for Neuroticism and satisfaction in romantic relationships: A systematic investigation of intra- and interpersonal processes with a longitudinal approach
Creators: name: Kreuzer, Marianne
name: Gollwitzer, Mario
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-9-erp-10.1177_08902070211001258 for Neuroticism and satisfaction in romantic relationships: A systematic investigation of intra- and interpersonal processes with a longitudinal approach by Marianne Kreuzer and Mario Gollwitzer in European Journal of Personality
sj-pdf-1-epb-10.1177_2399808320951205 - Supplemental material for Polycentric urban development and urban amenities: Evidence from Chinese cities
Creators: name: Mingshu Wang
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Geography
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-1-epb-10.1177_2399808320951205 for Polycentric urban development and urban amenities: Evidence from Chinese cities by Mingshu Wang in EPB: Urban Analytics and City Science
Partitë politike në Shqipëri (përmbledhje)
Creators: name: Krasniqi, Afrim
Publisher: name: KAS (Konrad Adenauer Stiftung)
Year: 2017

description: I.	Zhvillimi i partive politike në Shqipëri
II.	Partitë politike më të rëndësishme në Shqipëri
III.	Koalicionet politike në Shqipëri
IV.	Ideologjitë e partive në Shqipëri
V.	Demokracia brenda-partive në partitë shqiptare
VI.	Organizimi i brendshëm i partive shqiptare
VII.	Perspektiva të ardhshme e partive shqiptare
sj-docx-6-pmj-10.1177_02692163211001721 – Supplemental material for Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study
Creators: name: Sato, Takashi
name: Fujisawa, Daisuke
name: Arai, Daisuke
name: Nakachi, Ichiro
name: Takeuchi, Mari
name: Shigenari Nukaga
name: Kobayashi, Keigo
name: Ikemura, Shinnosuke
name: Terai, Hideki
name: Yasuda, Hiroyuki
name: Kawada, Ichiro
name: Sato, Yasunori
name: Satomi, Ryosuke
name: Takahashi, Saeko
name: Mizuha Haraguchi Hashiguchi
name: Nakamura, Morio
name: Oyamada, Yoshitaka
name: Terashima, Takeshi
name: Sayama, Koichi
name: Fumitake Saito
name: Sakamaki, Fumio
name: Inoue, Takashi
name: Naoki, Katsuhiko
name: Fukunaga, Koichi
name: Soejima, Kenzo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-docx-6-pmj-10.1177_02692163211001721 for Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study by Takashi Sato, Daisuke Fujisawa, Daisuke Arai, Ichiro Nakachi, Mari Takeuchi, Shigenari Nukaga, Keigo Kobayashi, Shinnosuke Ikemura, Hideki Terai, Hiroyuki Yasuda, Ichiro Kawada, Yasunori Sato, Ryosuke Satomi, Saeko Takahashi, Mizuha Haraguchi Hashiguchi, Morio Nakamura, Yoshitaka Oyamada, Takeshi Terashima, Koichi Sayama, Fumitake Saito, Fumio Sakamaki, Takashi Inoue, Katsuhiko Naoki, Koichi Fukunaga and Kenzo Soejima in Palliative Medicine
AWARENESS ABOUT ROS MEDIATED DNA METHYLATION CHANGES AMONG ALLIED HEALTH SCIENCE STUDENTS
Creators: name: Kethan Umakanth
name: Pooja. T
name: Sivakumar Ekambaram
name: Jagadeswaran
name: Dhanraj Ganapathy
Publisher: name: Zenodo
Year: 2024
Subjects: Awareness, Health, ROS, DNA Methylation.

description: Abstract

Introduction: Reactive oxygen species (ROS), including free radicals, play important roles in cellular signaling, being an important element of organismal homeostasis. ROS are implicated in the pathogenesis of many human diseases, and, in fact, it is not easy to find a disorder without ROS in its pathogenesis. Aim: This survey was conducted to assess the knowledge level and create awareness about Ros mediated DNA methylation changes among Allied Health Science students. Materials and Method: A cross-section research was conducted with a self-administered questionnaire containing ten questions distributed amongst 100 Allied Health Science Students. The questionnaire assessed the awareness about Ros mediated DNA methylation changes. The responses were recorded and analysed. Result: 48.5% respondents were aware of ROS mediated DNA methylation changes .50% were aware of mechanisms involves direct chemical modification of DNA. 50% were aware that it is a new invention. 37% of respondents have knowledge about the method. 31% were aware of the uses of mechanism. Conclusion: There is a limited awareness among allied health sciences about Ros mediatied DNA methylation and changes. Enhanced awareness initiatives and educational programmes together with increased importance for curriculum improvements that further promote knowledge and awareness of Ros mediated DNA methylation and changes among Allied Health Science Students.
O INSTITUTO JURÍDICO DA ADOÇÃO DE CRIANÇAS E ADOLESCENTES NO DIREITO COMPARADO ENTRE BRASIL E ARGENTINA
Creators: name: Martini, Micaela Daniela
name: Horongozo, Mikaeli
Publisher: name: Zenodo
Year: 2025
Subjects: direito
adoçao
Brasil
Argentina

description: O presente artigo tem como objetivo, a análise do instituto jurídico da adoção de crianças e adolescentes, no estudo comparativo entre o sistema jurídico brasileiro e Argentino. Com o estudo atual da doutrina e legislação, a pesquisa aponta similitudes e dissimilitudes do instituto nos dois países, no que concerne conceitos, finalidades, tipos e efeitos. Dentre as principais semelhanças, ocorre a previsão do princípio do melhor interesse da criança e do adolescente como orientador no processo de adoção além do princípio da afetividade. Por fim, os resultados do estudo mostraram que o principal interesse sempre será resguardar a proteção integral do menor tanto no Brasil quanto na Argentina. Sobre os procedimentos metodológicos acerca da caracterização da pesquisa, utilizou-se o método dedutivo.
Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer
Creators: name: Cheng, Y.-Y
name: Zhang, J
name: Qiu, N
name: Liu, Y
name: Huang, L
name: Shen, L
name: Lee, K.-H
name: Liu, Q
Publisher: name: Elsevier B.V.
Year: 2020

description: Triple negative breast cancer (TNBC) does not respond to checkpoint blockade immunotherapy as a result of immunosuppressive tumor microenvironment. To remodel the tumor microenvironment, we developed a liposome formulation to deliver a potential immunogenic cell death (ICD) inducing agent, 17-(allylamino)-17-demethoxygeldanamycin (17-AAG, or tanespimycin), in a tumor targeted manner to reverse the immunosuppressive microenvironment and facilitate the checkpoint blockade immunotherapy. The 17-AAG liposomes was prepared by thin film dispersion methods. The orthotopic 4T1 murine triple negative breast cancer model was studied. 17-AAG delivered by liposome remodeled the immunosuppressive microenvironment, significantly increased tumor infiltrating T cells, lowered the hypoxia level, decreased the suppressive lymphocytes such as tumor associated macrophages and myeloid derived suppressor cells in the tumor microenvironment. In addition, real-time PCR analysis revealed that chemokines and cytokines with immunosuppressive properties were notably reduced, which further facilitated the T cell mediated immunotherapy. Despite the fact that low dose 17-AAG liposomes demonstrated a limited therapeutic effect alone on 4T1 tumor, promising efficacy was observed when 17-AAG liposomes combined with checkpoint blockade immunotherapy. Taken together, 17-AAG liposomes could remodel the immunosuppressive microenvironment of triple negative breast cancer and facilitate the checkpoint blockade immunotherapy.
Additional file 1 of Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter radiopharmaceutical therapy
Creators: name: Bastiaannet, Remco
name: Liatsou, Ioanna
name: F Hobbs, Robert
name: Sgouros, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1: Figure S1. Additional method details.
sj-pdf-1-msj-10.1177_13524585211005339 – Supplemental material for Impact of COVID-19 on multiple sclerosis care and management: Results from the European Committee for Treatment and Research in Multiple Sclerosis survey
Creators: name: Portaccio, Emilio
name: Fonderico, Mattia
name: Hemmer, Bernhard
name: Derfuss, Tobias
name: Stankoff, Bruno
name: Selmaj, Krzysztof
name: Tintorè, Mar
name: Amato, Maria Pia
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-msj-10.1177_13524585211005339 for Impact of COVID-19 on multiple sclerosis care and management: Results from the European Committee for Treatment and Research in Multiple Sclerosis survey by Emilio Portaccio, Mattia Fonderico, Bernhard Hemmer, Tobias Derfuss, Bruno Stankoff, Krzysztof Selmaj, Mar Tintorè and Maria Pia Amato in Multiple Sclerosis Journal
Nanodelivery of cGAS-STING activators for tumor immunotherapy
Creators: name: Huang, L
name: Guo, J
Publisher: name: Elsevier Ltd
Year: 2022

description: Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote antitumor immunity. Development of activators for the cGAS-STING pathway (cGAS-STING activators) has profoundly revolutionized tumor immunotherapy. However, successful clinical application of cGAS-STING activators is contingent on having appropriate systems to achieve safe, effective, and specific delivery. There is an increasing emphasis on the design and application of nano drug delivery systems (NDDS) that can facilitate the delivery potential of cGAS-STING activators. In this review, we discuss barriers for translational development of cGAS-STING activators (DNA damaging drugs and STING agonists) and recent advances of NDDS for these agents in tumor immunotherapy.
Nanodrug delivery systems modulate tumor vessels to increase the enhanced permeability and retention effect
Creators: name: Sun, L
name: Chen, Y
name: Huang, L
name: Huang, D
Publisher: name: MDPI AG
Year: 2021

description: The use of nanomedicine for antitumor therapy has been extensively investigated for a long time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently regarded as an effective way to bring drugs to tumors, especially macromolecular drugs and drug-loaded pharmaceutical nanocarriers. However, a disordered vessel network, and occluded or embolized tumor blood vessels seriously limit the EPR effect. To augment the EPR effect and improve curative effects, in this review, we focused on the perspective of tumor blood vessels, and analyzed the relationship among abnormal angiogenesis, abnormal vascular structure, irregular blood flow, extensive permeability of tumor vessels, and the EPR effect. In this commentary, na-noparticles including liposomes, micelles, and polymers extravasate through the tumor vascula-ture, which are based on modulating tumor vessels, to increase the EPR effect, thereby increasing their therapeutic effect.
Roman enamelled copper-alloy disc brooch
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Roman bronze disc-brooch, diam. 2.7cm. In centre a shallow cast cell with lost setting; around this a plain ridge, then a zone of bronze dots in relief possibly in the remains of an enamel field; then a border of scallop decoration. The whole very decayed. On the back a damaged pin catch, and at the other side a pair of pierced lugs with a bronze bolt between and the remainder of the spring coil, also bronze.
Mitochondrial DNA variation in honey bee (Apis mellifera) colonies from Arkansas, U.S.
Creators: name: Cleary, Dylan
name: Adams, Richard
name: Szalanski, Allen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: This study characterized the mitochondrial DNA (mtDNA) genetic variation in Arkansas honey bee, Apis mellifera L., by sequencing a portion of the mitochondrial cytochrome oxidase (COI-COII) intergenic region). The samples were primarily of hobbyist-managed origin (n = 180), as well as 32 feral colonies and two swarms. Of the 214 honey bee colonies and swarms sampled, 23 haplotypes were observed. The haplotypes were from the: A (African) (1.87%); C (South eastern European) (92.52%); M (Northern and Western European) (3.27%); and O (Near East and Middle East) lineages (2.34%). Six C lineage haplotypes were predominantly detected (n = 189, 88.31%), all of which are common in U.S. commercial queen breeder colonies. The remaining 27 honey bee samples represented 19 haplotypes, all of which are absent from commercial queen breeder colonies but have been observed in feral honey bee populations collected in other States. These haplotypes, particularly those from the M and O lineages, are likely hundred-year-old remnants of historical importations, surviving for generations despite the arrival of threats, such as Varroa mites. Understanding honey bee genetics and population structure are valuable for maintaining genetic diversity. Results from this study provide evidence that Arkansas honey bee populations differ from U.S. commercial queen breeder colonies. The 15 haplotypes detected in our Arkansas study absent from commercial queen breeder colonies could be important sources of genetic diversity in future honey bee breeding programs, highlighting the importance of State-level genetic surveys.
Additional file 1 of Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study
Creators: name: Angriman, Federico
name: Lawler, Patrick R.
name: Shah, Baiju R.
name: Martin, Claudio M.
name: Scales, Damon C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplementary appendix.
Everybody pro and against communism: paradoxes in the change of the political system and attitudes towards communism (1990–1992)
Creators: name: Krasniqi, Afrim
Publisher: name: Humanities Commons
Year: 2019

description: The retrospective analysis of the events of 1990-1992, and their treatment today in instruments of collective and institutional memory, proves the thesis that the historical period of breaking with the past and forming the new system is characterized more by the feature of the displacement of elites, of imposition by an urban liberal minority, than by a process that has at its foundations a project of structural reform or democratic revolution. In many respects, the new system continued to function as an appendix severed from the old system, and the main bearers of this phenomenon were the main political parties and the institutions they created. There are a series of arguments that support the assessment that the features of this period lie at the foundation of political transition and in many of its elements, and that they determine or continue to condition it. The transition to democracy, more than a legal or political act, turned out to be an extraordinary test of moral values, of cultural formation, and of the sense of responsibility.  The findings do not allow us to understand clearly whether the results achieved during the transition, especially at its beginning, constitute the most that could have been achieved by elites with the same upbringing but with different perspectives and political interests, or whether we are dealing with the impossibility of balancing due to the influence of the communist heritage and geopolitical developments in the region. The dilemma of whether the transition constitutes the maximum of values and standards that Albanian society could offer continues to be dominant, as well as simultaneously a critical indicator of our cultural ability to represent the values of a new system not lived through during our age-old state history.
Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer
Creators: name: Huang, L
name: Song, W
name: Liu, Y
name: Zhang, J
name: Shen, L
name: Li, X
Publisher: name: American Chemical Society
Year: 2019

description: Microsatellite-stable colorectal cancer (CRC) is known to be resistant to immunotherapy. The combination of quercetin (Q) and alantolactone (A) was found to induce synergistic immunogenic cell death (ICD) at a molar ratio of 1:4 (Q:A). To achieve ratiometric loading and delivery, the micellar delivery of Q and A (QA-M) was developed with high entrapment efficiency and drug loading at an optimal ratio. QA-M achieved prolonged blood circulation and increased tumor accumulation for both drugs. More importantly, QA-M retained the desired drug ratio (molar ratio of Q to A = 1:4) in tumors at 2 and 4 h after intravenous injection for synergistic immunotherapy. Tumor growth was significantly inhibited in murine orthotopic CRC by the treatment of QA-M compared to PBS and the combination of free drugs (p < 0.005). The combination of nanotherapy stimulated the host immune response to induce long-term tumor destruction and induced memory tumor surveillance with a 1.3-fold increase in survival median time compared to PBS (p < 0.0001) and a combination of free drugs (p < 0.0005). The synergistic therapeutic effect induced by codelivery of Q and A is capable of reactivating antitumor immunity by inducing ICD, causing cell toxicity and modulating the immune-suppressive tumor microenvironment. Such a combination of Q and A with synergistic effects entrapped in a simple and safe nanodelivery system may provide the potential for scale-up manufacturing and clinical applications as immunotherapeutic agents for CRC.
Der Lichtstrom und der Fall mit mehreren Karten
Creators: name: Schröer, Harald
Publisher: name: Zenodo
Year: 2015
Subjects: luminous flux, chart, illumination,absorption,surface,source,illuminance

description: Behandelt wird hier der Lichtstrom und die Beleuchtungsstärke durch allgemeine Flächen. Die Flächen und die Lichtquelle sind durch mehrere Karten parametriziert. Die Absorption wird auch berücksichtigt.
description: German
Everybody pro and against communism: paradoxes in the change of the political system and attitudes towards communism (1990–1992)
Creators: name: Krasniqi, Afrim
Publisher: name: IDMC
Year: 2019

description: The retrospective analysis of the events of 1990-1992, and their treatment today in instruments of collective and institutional memory, proves the thesis that the historical period of breaking with the past and forming the new system is characterized more by the feature of the displacement of elites, of imposition by an urban liberal minority, than by a process that has at its foundations a project of structural reform or democratic revolution. In many respects, the new system continued to function as an appendix severed from the old system, and the main bearers of this phenomenon were the main political parties and the institutions they created. There are a series of arguments that support the assessment that the features of this period lie at the foundation of political transition and in many of its elements, and that they determine or continue to condition it. The transition to democracy, more than a legal or political act, turned out to be an extraordinary test of moral values, of cultural formation, and of the sense of responsibility.

The findings do not allow us to understand clearly whether the results achieved during the transition, especially at its beginning, constitute the most that could have been achieved by elites with the same upbringing but with different perspectives and political interests, or whether we are dealing with the impossibility of balancing due to the influence of the communist heritage and geopolitical developments in the region. The dilemma of whether the transition constitutes the maximum of values and standards that Albanian society could offer continues to be dominant, as well as simultaneously a critical indicator of our cultural ability to represent the values of a new system not lived through during our age-old state history.
Nanomaterial Manipulation of Immune Microenvironment in the Diseased Liver
Creators: name: Hu, M
name: Huang, L
Publisher: name: Wiley-VCH Verlag
Year: 2019

description: The liver contains intricate immunological mechanisms, capable of inducing both immune activation and suppression for the maintenance of a homeostatic immune environment. From an immunological point of view, chronic liver disease is indeed a result of the imbalance of pro- and anti-inflammatory responses. Therefore, application of immunotherapy in liver diseases is logical and contains a huge potential for future development. Despite rapid advances in immunotherapy, research at the interdisciplinary interface of immunology and material science is important for further enhancement of immunotherapeutic efficiency and reduction of side effects. Moreover, the liver is particularly suitable for the application of nanomaterial-based immunotherapy due to its biological filtration function to sequester a majority of administrated nanoparticles from systemic circulation. Here, an insight of advanced liver diseases and how liver cells exert their immune functions in the diseased liver is summarized first to provide basic principles for therapeutic application, followed by an overview of the latest studies on nanomaterial-based immunotherapy for liver diseases.
Additional file 2 of Facultative mycorrhization in a fern (Struthiopteris spicant L. Weiss) is bound to light intensity
Creators: name: Guillen-Otero, Thais
name: Lee, Soon-Jae
name: Hertel, Dietrich
name: Kessler, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: Supplementary Material 2
Effect of dietary supplement on the reproductive traits, products and behavioral characteristics of the European honey bee (Apis mellifera)
Creators: name: Shadmehr, Sara
name: Chamani, Mohammad
name: Tajabadi, Naser
name: Sadeghi, Ali Asghar
name: Seidavi, Alireza
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: We evaluated the effects of dietary supplements on hive populations of the European honey bee (Apis mellifera) through experimental trials. The population, reproduction rate, quality of honey, quantity and quality of venom, and behavioral characteristics of 15 hives were assessed in a randomized experimental design with three groups and five replicates. Each replicate contained one modern Langstroth–Hive. The experimental period was 86 days, and each hive in the control group (control), received 500 mL syrup without dietary supplement per day (sugar and water in equal quantities), Group 1 received 500 mL syrup with 5 g dietary supplement added, and Group 2 received 500 mL syrup with 10 g dietary supplement added. The colony population and reproduction rate increased significantly in both treatment groups (p < 0.01). Honey production increased significantly in Group 2 (p < 0.05). Diastase activity and protein and sucrose content in honey increased significantly in both groups (p < 0.05). The general behavior of the bees improved significantly in both groups (p < 0.01). Aggressive behavior decreased significantly in Group 2 (p < 0.01). Overall, Group 2 showed statistically significant improvements which were better than Group 1.
Additional file 3 of Facultative mycorrhization in a fern (Struthiopteris spicant L. Weiss) is bound to light intensity
Creators: name: Guillen-Otero, Thais
name: Lee, Soon-Jae
name: Hertel, Dietrich
name: Kessler, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: Supplementary Material 3
Supplemental Material, sj-docx-1-jpx-10.1177_2374373521997221 - Complaints and Satisfaction of Patients in Psychiatric Hospitals: The Case of Israel
Creators: name: Semyonov-Tal, Keren
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Medicine

description: Supplemental Material, sj-docx-1-jpx-10.1177_2374373521997221 for Complaints and Satisfaction of Patients in Psychiatric Hospitals: The Case of Israel by Keren Semyonov-Tal in Journal of Patient Experience
Institutionelle Forschungsdaten-Policies. Interview mit Paolo Budroni
Creators: name: Hiemenz, Bea
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 020 Bibliotheks- und Informationswissenschaften
subject: FD-Policy
subject: Forschungsdaten-Policy
subject: Forschungsdaten
subject: Forschungsdatenmanagement
subject: FAIR Data Principles
subject: Leitlinie
subject: Richtlinie
subject: Grundsätze
subject: FDMentor

description: Das BMBF-Verbundprojekt FDMentor (01.05.2017-30.04.2019) zielt darauf ab, die strategische Entwicklung des Forschungsdatenmanagements an deutschen Hochschulen gezielt zu unterstützen und zu beschleunigen. Im Fokus des Teilprojekts „Modalitäten und Entwicklung institutioneller Forschungsdaten-Policies“ der TU Berlin stehen die Entwicklung eines nachnutzbaren Forschungsdaten-Policy-Kits für die Erstellung von FD-Policies an deutschen Universitäten und Hochschulen sowie die Entwicklung eines Leitfadens zur Unterstützung der strategischen Prozesse. Um Rückschlüsse für die Erarbeitung eines FD-Policy-Kit in Deutschland zu ziehen, wurde Paolo Budroni, der Leiter des Workpackage Policy Development and Alignment im H2020-Projekt LEARN, zu den Hintergründen der LEARN-Muster-Policy und der LEARN-Guidelines und zum strategischen Vorgehen bei der Etablierung einer FD-Policy befragt.
Unveiling beekeepers’ use and preference of precision apiculture systems
Creators: name: Vardakas, Philippos
name: Mainardi, Giulia
name: Minaud, Etienne
name: Patalano, Solenn
name: Rebaudo, François
name: Requier, Fabrice
name: Steffan-Dewenter, Ingolf
name: Hatjina, Fani
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Amid growing ecological concerns surrounding honey bee colony mortality, Precision Apiculture Systems (PAS) emerge as promising monitoring tools to safeguard bee health as well as to improve the beekeeping practices and economic sustainability of apiary operations. These systems offer critical insights into colony dynamics, aiding decision-making processes in beekeeping. Despite a surge in relevant academic research, knowledge of actual PAS usage and preference among beekeepers remains limited. To fill this gap, a standardized survey was conducted among beekeepers in France, Germany, and Greece. This focused geographical scope survey aimed to determine the extent of current and potential PAS adoption, the motivations behind usage or avoidance, and ascertain future preferences. Among the 538 respondents, 45% reported utilizing some form of PAS, with beekeeping scales being the most commonly used. The study revealed that the use of PAS positively correlates with both the number of hives managed and the distance of the apiary from the beekeeper’s residence. Overall, 90% of respondents expressed a certain degree of satisfaction with their use of PAS, although the high costs of these tools were identified as a primary obstacle to broader adoption. About 48% of the beekeepers preferred systems with external sensors, highlighting a clear demand for non-invasive health-related colony information. The advantages that foster PAS usage include decision-making support and improved efficiency in monitoring colony growth and honey productivity. These findings can assist in making PAS more accessible to beekeepers, with the aim to enhance colony performance and decision-making capabilities, thus addressing honey bee colony mortality.
La muerte es un producto de su imaginación: la falacia definitiva como un estereotipo desadaptativo, - Argumento materialista de que "la espiritualidad es irreal": estar más allá de la medida [Miller y Thompson] - Filtrado - William James
Creators: name: Peck Jr, Charles
Publisher: name: unknown
Year: 2008
Subjects: subject: Logic
subject: Latin America
subject: Spirituality
subject: Hispanic Americans
subject: Naturalistic fallacy
subject: Spanish literature
subject: Psychology
subject: FOS: Psychology
subject: Philosophy, Spanish

description: La "profecía de Mar" de Jung: el materialismo académico impulsado por el escapismo extremo de los psicólogos materialistas
Pregunta de un periodista a Carl Jung: ¿Cree que, dentro de veinte años, a alguien le importará el espíritu de los símbolos, de lleno en la era de los viajes interplanetarios, con los Sputniks, los Gagarin y los Shephards? ¿No llegará el espíritu a parecer pasado de moda? El Dr. Jung sonríe astutamente y afirma: "Tarde o temprano el hombre tendrá que volver a sí mismo, aunque sea de las estrellas. Todo esto que está pasando ahora es una forma extrema de escapismo, porque es más fácil llegar a Marte que encontrarse a uno mismo. Si el hombre no se encuentra a sí mismo, entonces enfrenta el mayor de los peligros: su propia aniquilación.
Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis
Creators: name: Rojas, J.D
name: Graboski, A
name: Zhang, J
name: Yazdimamaghani, M
name: Wang, A.Z
name: Li, L
name: Hu, M
name: Sultanpuram, N
name: McCabe, E
name: Huang, L
name: Sendi, H
name: Moody, A.S
name: Dayton, P.A
name: Wang, J
Publisher: name: American Association for Cancer Research Inc.
Year: 2021

description: Liver metastasis is a leading cause of cancer morbidity and mortality. Thus, there has been strong interest in the development of therapeutics that can effectively prevent liver metastasis. One potential strategy is to utilize molecules that have broad effects on the liver microenvironment, such as miR-122, a liver-specific miRNA that is a key regulator of diverse hepatic functions. Here we report the development of a nanoformulation miR-122 as a therapeutic agent for preventing liver metastasis. We engineered a galactose-targeted lipid calcium phosphate (Gal-LCP) nanoformulation of miR-122. This nanotherapeutic elicited no significant toxicity and delivered miR-122 into hepatocytes with specificity and high efficiency. Across multiple colorectal cancer liver metastasis models, treatment with Gal-LCP miR-122 treatment effectively prevented colorectal cancer liver metastasis and prolonged survival. Mechanistic studies revealed that delivery of miR-122 was associated with downregulation of key genes involved in metastatic and cancer inflammation pathways, including several proinflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes. Moreover, Gal-LCP miR-122 treatment was associated with an increased CD8+/CD4+ T-cell ratio and decreased immunosuppressive cell infiltration, which makes the liver more conducive to antitumor immune response. Collectively, this work presents a strategy to improve cancer prevention and treatment with nanomedicine-based delivery of miRNA.
The effect of diet on the development of pheromone signals in Apis mellifera scutellata workers
Creators: name: du Rand, Esther E.
name: Pirk, Christian W. W.
name: Okosun, Olabimpe O.
name: Yusuf, Abdullahi A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The social organization of honey bee colonies is predominantly controlled by the pheromonal cues produced by the queen, workers and brood. Pheromone composition is dependent on the social environment, context, audience and physiological status of the individual. In the absence of the queen, ontogenic changes and reproductive status modulate pheromone production and composition in workers. In these queenless workers, pheromonal status influences diet with dominant workers consuming less pollen than subordinates as they are fed protein jelly through trophallaxis, which positively correlates with their ovarian activation. However, it is not known to what extent diet affects pheromonal status in queenless workers. To investigate whether diet affects the production of glandular signals, Apis mellifera scutellata workers were fed carbohydrate-only or protein-rich diets for twenty-five days. The mandibular and tergal gland secretions were analyzed using gas chromatography and the ovarian activation statuses were evaluated. A clear link between diet and pheromone profiles was observed with workers fed a protein-rich diet producing mandibular gland chemical profiles more typical of queens. The effect of diet on tergal gland chemical profiles was less distinct, but a shift from fatty acid to n-alkane components was seen in the older workers irrespective of diet, most likely due to ontogeny. Though mandibular gland profiles were queen-like with high proportions of 9-HDA, the levels of 9-ODA remained in the range of non-reproductive workers and the ovaries were not fully activated. This suggests that diet could prime queenless workers to become false queens, but do not trigger the transformation into false queens.
La muerte es un producto de su imaginación: la falacia definitiva como un estereotipo desadaptativo, - Argumento materialista de que "la espiritualidad es irreal": estar más allá de la medida [Miller y Thompson] - Filtrado - William James
Creators: name: Peck Jr, Charles
Publisher: name: Humanities Commons
Year: 2008
Subjects: subject: Philosophy, Spanish
subject: Latin America
subject: Hispanic Americans
subject: Spirituality
subject: Logic
subject: Psychology
subject: FOS: Psychology
subject: Naturalistic fallacy
subject: Spanish literature

description: La "profecía de Mar" de Jung: el materialismo académico impulsado por el escapismo extremo de los psicólogos materialistas Pregunta de un periodista a Carl Jung: ¿Cree que, dentro de veinte años, a alguien le importará el espíritu de los símbolos, de lleno en la era de los viajes interplanetarios, con los Sputniks, los Gagarin y los Shephards? ¿No llegará el espíritu a parecer pasado de moda? El Dr. Jung sonríe astutamente y afirma: “Tarde o temprano el hombre tendrá que volver a sí mismo, aunque sea de las estrellas. Todo esto que está pasando ahora es una forma extrema de escapismo, porque es más fácil llegar a Marte que encontrarse a uno mismo. Si el hombre no se encuentra a sí mismo, entonces enfrenta el mayor de los peligros: su propia aniquilación.
Eine Randverteilung von einer gleichmäßigen Verteilung im Inneren einer Ellipse
Creators: name: Schröer, Harald
Publisher: name: Zenodo
Year: 2019
Subjects: Randverteilung, gleichmäßig, Verteilung, Wahrscheinlichkeitsdichte, Ellipse, Innere, R², Flächeninhalt

description: Es wird eine gleichmäßige Verteilung innerhalb einer Ellipse betrachtet. Anschließend wird eine Randverteilung berechnet.
Eine Wahrscheinlichkeitsdichte über einen Parabelausschnitt mit Randverteilungen und bedingten Wahrscheinlichkeitsdichten
Creators: name: Schröer, Harald
Publisher: name: Zenodo
Year: 2019
Subjects: Wahrscheinlichkeitsdichte, Parabel,Ausschnitt, Randverteilungen,bedingte Wahrscheinlichkeit,Parabelfläche,Zufallsvariable, Zufallsvektor

description: Berechnung einer Wahrscheinlichkeitsdichte über einen Parabelausschnitt, Ermittlung der zugehörigen Randverteilungen und der bedingten Wahrscheinlichkeitsdichten
Natural products remodel cancer-associated fibroblasts in desmoplastic tumors
Creators: name: Chen, R
name: Hu, K
name: Huang, L
Publisher: name: Chinese Academy of Medical Sciences
Year: 2020

description: Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which usually result in therapeutic resistance. Current treatment prescriptions for desmoplastic tumors are usually not sufficient to eliminate the malignancy. Recently, through modulating cancer-associated fibroblasts (CAFs) which are the most abundant cell type among all stromal cells, natural products have improved chemotherapies and the delivery of nanomedicines to the tumor cells, showing promising ability to improve treatment effects on desmoplastic tumors. In this review, we discussed the latest advances in inhibiting desmoplastic tumors by modeling CAFs using natural products, highlighting the potential therapeutic abilities of natural products in targeting CAFs for cancer treatment.