cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The functional interaction of EGFR with AT1R or TP in primary vascular smooth muscle cells triggers a synergistic regulation of gene expression
Creators: name: Dubourg, Virginie
name: Schreier, Barbara
name: Schwerdt, Gerald
name: Rabe, Sindy
name: Benndorf, Ralf
name: Gekle, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 611

description: In vivo, cells are simultaneously exposed to multiple stimuli whose effects are difficult to distinguish. Therefore, they are often investigated in experimental cell culture conditions where stimuli are applied separately. However, it cannot be presumed that their individual effects simply add up. As a proof-of-principle to address the relevance of transcriptional signaling synergy, we investigated the interplay of the Epidermal Growth Factor Receptor (EGFR) with the Angiotensin-II (AT1R) or the Thromboxane-A2 (TP) receptors in murine primary aortic vascular smooth muscle cells. Transcriptome analysis revealed that EGFR-AT1R or EGFR-TP simultaneous activations led to different patterns of regulated genes compared to individual receptor activations (qualitative synergy). Combined EGFR-TP activation also caused a variation of amplitude regulation for a defined set of genes (quantitative synergy), including vascular injury-relevant ones (Klf15 and Spp1). Moreover, Gene Ontology enrichment suggested that EGFR and TP-induced gene expression changes altered processes critical for vascular integrity, such as cell cycle and senescence. These bioinformatics predictions regarding the functional relevance of signaling synergy were experimentally confirmed. Therefore, by showing that the activation of more than one receptor can trigger a synergistic regulation of gene expression, our results epitomize the necessity to perform comprehensive network investigations, as the study of individual receptors may not be sufficient to understand their physiological or pathological impact.
Transit Timing Analysis in the HAT-P-32 system
Creators: name: Seeliger, M.
name: Dimitrov, D.
name: Kjurkchieva, D.
name: Mallonn, M.
name: Fernandez, M.
name: Kitze, M.
name: Casanova, V.
name: Maciejewski, G.
name: Ohlert, J. M.
name: Schmidt, J. G.
name: Pannicke, A.
name: Puchalski, D.
name: Göğüş, E.
name: Güver, T.
name: Bilir, S.
name: Ak, T.
name: Hohle, M. M.
name: Schmidt, T. O. B.
name: Errmann, R.
name: Jensen, E.
name: Cohen, D.
name: Marschall, L.
name: Saral, G.
name: Bernt, I.
name: Derman, E.
name: Gałan, C.
name: Neuhäuser, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the results of 45 transit observations obtained for the transiting exoplanet HAT-P-32b. The transits have been observed using several telescopes mainly throughout the YETI network. In 25 cases, complete transit light curves with a timing precision better than $1.4\:$min have been obtained. These light curves have been used to refine the system properties, namely inclination $i$, planet-to-star radius ratio $R_\textrm{p}/R_\textrm{s}$, and the ratio between the semimajor axis and the stellar radius $a/R_\textrm{s}$. First analyses by Hartman et al. (2011) suggest the existence of a second planet in the system, thus we tried to find an additional body using the transit timing variation (TTV) technique. Taking also literature data points into account, we can explain all mid-transit times by refining the linear ephemeris by 21ms. Thus we can exclude TTV amplitudes of more than $\sim1.5$min.
description: MNRAS accepted; 13 pages, 10 figures
A large-deviations approach to gelation
Creators: name: Andreis, Luisa
name: König, Wolfgang
name: Patterson, Robert I. A.
Publisher: name: Weierstrass Institute
Year: 2019
Subjects: subject: Coagulation process
subject: multiplicative coalescent
subject: gelation
subject: phase transition
subject: large deviations
subject: Erdős-Rényi random graph
subject: 05C80
subject: 60F10
subject: 60K35
subject: 82B26

description: A large-deviations principle (LDP) is derived for the state, at fixed time, of the multiplicative coalescent in the large particle number limit. The rate function is explicit and describes each of the three parts of the state: microscopic, mesoscopic and macroscopic. In particular, it clearly captures the well known gelation phase transition given by the formation of a particle  containing a positive fraction of the system mass at time t=1. Via a standard map of the multiplicative coalescent onto a time-dependent version of the Erdős-Rényi random graph, our results can also be rephrased as an LDP for the component sizes in that graph.  Our proofs rely on estimates and asymptotics for the probability that smaller Erdős-Rényi graphs are connected.
Design, synthesis and characterization of vitrimers with low topology freezing transition temperature
Creators: name: Krishnan, Baiju Pazhamkalathil
name: Saalwächter, Kay
name: Adjedje, Vico K. B.
name: Binder, Wolfgang H.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 541

description: Vitrimers are crosslinked polymeric materials that behave like fluids when heated, regulated by the kinetics of internal covalent bond-exchange that occurs rapidly at or above the topology freezing transition temperature (Tv) of the vitrimer, making these materials readily reprocessable and recyclable. We report two novel multiphase vitrimeric materials prepared by the cross-linking of two polymers, namely poly(triethylene glycol sebacate) and poly(2-hydroxyethyl acrylate), using zinc acetate or tin(II) 2-ethylhexanoate as catalysts, which exhibit significantly low Tv temperatures of 39 °C and 29 °C, respectively. The transesterification reactions allow rapid and pronounced stress relaxation at high temperatures, following the Arrhenius law. The lower Tv of these vitrimers could be attributable to the flexible long chains of these polymers and the significant excess of OH moieties present along the main chain of the polymer. The design of such multiphase vitrimers is not only useful for the practical application of vitrimers to reduce plastic waste but could also facilitate further development of functional polymer materials that can be reprocessed at low temperatures.
Origin Of the enhanced flexoelectricity of relaxor ferroelectrics
Creators: name: Narvaez, Jackeline
name: Catalan, Gustau
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have measured the bending-induced polarization of Pb(Mg1/3Nb2/3)O3-PbTiO3 single crystals with compositions at the relaxor-ferroelectric phase boundary. The crystals display very large flexoelectricity, with flexocoupling coefficients an order of magnitude bigger than the theoretical upper limit set by the theories of Kogan and Tagantsev. This enhancement persists in the paraphrase up to a temperature T* that coincides with the start of elastic softening in the crystals. Analysis of the temperature dependence and cross-correlation between flexoelectric, dielectric and elastic properties indicates that the large bendinginduced polarization of relaxor ferroelectrics is not caused by intrinsically giant flexoelectricity, but by the reorientation of polar nanotwins that become ferroelastically active below T*.
title: The Electronic Structure of 2-Azapentalenes. Photoelectron Spectroscopic Investigations
Creators: name: Eckert-Maksić, Mirjana
name: Gleiter, Rolf
name: Hafner, Klaus
name: Kläs, Heinz-Gerd
Publisher: name: Wiley
Year: 2022

description: The He(I) photoelectron spectra of eight 2-azapentalenes, substituted in 1,3-position by electron releasing groups (dimethylamino, ethoxy, and tert-butyl) revealed that the first four ionization energies (6.4–9.3 eV) are due to ionziation from π MO's. This assignment is based on the comparison with the PE data of 1,3-bis(dimethylamino)pentalene (10) and the results of MNDO calculations. The comparison between experiment and calculations suggests that the first two bands are due to ionizations from π MO's mainly localized in the pentalene moiety.
The memory B cell response to influenza vaccination is impaired in older persons
Creators: name: Burton, Alice R
name: Guillaume, Stephane M
name: Foster, William S
name: Wheatley, Adam K
name: Hill, Danika L
name: Carr, Edward J
name: Linterman, Michelle A
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology

description: Influenza infection imparts an age-related increase in mortality and morbidity. The most effective countermeasure is vaccination; however, vaccines offer modest protection in older adults. To investigate how aging impacts the memory B cell response, we track hemagglutinin-specific B cells by indexed flow sorting and single-cell RNA sequencing (scRNA-seq) in 20 healthy adults that were administered the trivalent influenza vaccine. We demonstrate age-related skewing in the memory B cell compartment 6 weeks after vaccination, with younger adults developing hemagglutinin-specific memory B cells with an FcRL5+ “atypical” phenotype, showing evidence of somatic hypermutation and positive selection, which happened to a lesser extent in older persons. We use publicly available scRNA-seq from paired human lymph node and blood samples to corroborate that FcRL5+ atypical memory B cells can derive from germinal center (GC) precursors. Together, this study shows that the aged human GC reaction and memory B cell response following vaccination is defective.
Twisting and Bending Stress in DNA Minicircles
Creators: name: Zoli, Marco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biomolecules (q-bio.BM)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The interplay between bending of the molecule axis and appearance of disruptions in circular DNA molecules, with $\sim 100$ base pairs, is addressed. Three minicircles with different radii and almost equal content of AT and GC pairs are investigated. The DNA sequences are modeled by a mesoscopic Hamiltonian which describes the essential interactions in the helix at the level of the base pair and incorporates twisting and bending degrees of freedom. Helix unwinding and bubble formation patterns are consistently computed by a path integral method that sums over a large number of molecule configurations compatible with the model potential. The path ensembles are determined, as a function of temperature, by minimizing the free energy of the system. Fluctuational openings appear along the helix to release the stress due to the bending of the molecule backbone. In agreement with the experimental findings, base pair disruptions are found with larger probability in the smallest minicircle of \textit{66-bps} whose bending angle is $\sim 6^{o} $. For this minicircle, a sizeable untwisting is obtained with the helical repeat showing a step-like increase at $τ=\,315K$. The method can be generalized to determine the bubble probability profiles of open ends linear sequences.
description: Soft Matter (2014), in press
Setting of the magnetic structure of chiral kagome antiferromagnets by a seeded spin-orbit torque
Creators: name: Pal, Banabir
name: Hazra, Binoy K.
name: Göbel, Börge
name: Jeon, Jae-Chun
name: Pandeya, Avanindra K.
name: Chakraborty, Anirban
name: Busch, Oliver
name: Srivastava, Abhay Kant
name: Deniz, Hakan
name: Taylor, James Mark
name: Meyerheim, Holger
name: Mertig, Ingrid
name: Yang, See-Hun
name: Parkin, Stuart S. P.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 538

description: The current-induced spin-orbit torque switching of ferromagnets has had huge impact in spintronics. However, short spin-diffusion lengths limit the thickness of switchable ferromagnetic layers, thereby limiting their thermal stability. Here, we report a previously unobserved seeded spin-orbit torque (SSOT) by which current can set the magnetic states of even thick layers of the chiral kagome antiferromagnet Mn3Sn. The mechanism involves setting the orientation of the antiferromagnetic domains in a thin region at the interface with spin currents arising from an adjacent heavy metal while also heating the layer above its magnetic ordering temperature. This interface region seeds the resulting spin texture of the entire layer as it cools down and, thereby, overcomes the thickness limitation of conventional spin-orbit torques. SSOT switching in Mn3Sn can be extended beyond chiral antiferromagnets to diverse magnetic systems and provides a path toward the development of highly efficient, high-speed, and thermally stable spintronic devices.
Sigma-terms and axial charges for hyperons and charmed baryons
Creators: name: Alexandrou, C.
name: Hadjiyiannakou, K.
name: Jansen, K.
name: Kallidonis, Ch.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present results for the $σ$-terms and axial charges for various hyperons and charmed baryons using $N_f=2+1+1$ twisted mass fermions. For the computation of the three-point function we use the fixed current method. For one of the $N_f=2+1+1$ ensembles with pion mass of 373 MeV we compare the results of the fixed current method with those obtained with a stochastic method for computing the all-to-all propagator involved in the evaluation of the three point functions.
description: Talk presented at 31st International Symposium on Lattice Field Theory LATTICE 2013, July 29 - August 3, 2013, Mainz, Germany, PoS(LATTICE 2013)279. 7 pages and6 figures
Extraction Method of Fine Granular Performance from Scintillator Strip Electromagnetic Calorimeter
Creators: name: Kotera, Katsushige
name: Jeans, Daniel
name: Miyamoto, Akiya
name: Takeshita, Tohru
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We describe an algorithm which has been developed to extract fine granularity information from an electromagnetic calorimeter with strip-based readout. Such a calorimeter, based on scintillator strips, is being developed to apply particle flow reconstruction to future experiments in high energy physics. Tests of this algorithm in full detector simulations, using strips of size 45 x 5 mm^2 show that the performance is close to that of a calorimeter with true 5 x 5 mm^2 readout granularity. The performance can be further improved by the use of 10 x 10 mm^2 tile- shaped layers interspersed between strip layers.
description: 11 pages, 10 figures
A comparison of depressive symptoms in medical and psychology students in Germany : associations with potential risk and resilience factors
Creators: name: Kindt, Tordis
name: Rabkow, Nadja
name: Pukas, Lilith
name: Keuch, Lea
name: Sapalidis, Alexandra
name: Piloty-Leskien, Anna
name: Röhler, Jonas
name: Proyer, René T.
name: Watzke, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 152

description: Background: Previous studies have shown that medical students are more prone to suffer from symptoms related to depression than other students. Even though there is some evidence that psychology students also experience such symptoms, research concerning the mental health of future psychologists is scarce. Objective: The aims of this study were threefold: (a) to determine the prevalence of symptoms related to depression among medical and psychology students (b) to investigate risk factors, which may have a potential influence on the development of depressive symptoms and (c) to examine resilience factors in order to indicate possible approaches to improve the mental health of the students. Methods: A total of 673 medical and psychology students completed the Beck Depression Inventory-II (BDI-II) to assess depressive symptoms, a neuroticism scale, and a standardized questionnaire for 13 risk and eight resilience factors derived from the literature. Results: While the results of previous research concerning the prevalence of depressive symptoms could be replicated for medical students (22% exceeding the cut-off in the BDI-II), psychology students demonstrated an even higher prevalence (28%). Ten potential risk factors and five potential resilience factors could be identified, which also showed a cumulative effect: The more risk factors students reported, the more depressive symptoms they experienced; the inverse effect was observed for resilience factors. Conclusions: Not only medical but also psychology students show elevated depressive symptomatology. In the university context, notably, the pressure to perform represents a potential risk factor, whereas the presence of just two resilience factors such as emotional support and study satisfaction contribute to a decrease of symptoms.
Supply Control Savings for Hog Slaughtering-Processing Plants
Creators: name: Holtman, J. B.
name: Sullivan, J. D.
name: Barreto, H. F.
name: Holtman, J. B.
name: Sullivan, J. D.
name: Barreto, H. F.
Publisher: name: Unknown
Year: 1974
Subjects: subject: Livestock Production/Industries
subject: Production Economics
subject: Research Methods/ Statistical Methods
subject: Hogs
subject: Marketing
subject: FOS: Economics and business
subject: Supply
subject: Control
subject: Costs
subject: Slaughtering
subject: Processing
subject: Economies of scale
subject: Seasonal
subject: Fluctuations

description: According to a random-process simulation model, slaughter plant cost savings of over 10 percent could be realized if complete market hog supply control were to be obtained. For the five sizes of plants studied, costs could be reduced by an average of $1.33 per hog. Cost savings via complete supply control ranged from $1.02 per hog for a 600-head-per-hour plant to $1.80 per hog for a 50-head-per-hour plant. Even though a high daily variation was considered, seasonal variation was the major determinant of costs attributed to supply variation. A feature of the model used in the systems analysis is the random component in determining the actual per hour productivity of workers in the slaughtering, cutting, processing, and rendering operations.
Decision tree analyses to explore the relevance of multiple sex/gender dimensions for the exposure to green spaces : results from the KORA INGER study
Creators: name: Dandolo, Lisa Catherine
name: Hartig, Christina
name: Telkmann, Klaus
name: Horstmann, Sophie
name: Schwettmann, Lars
name: Selsam, Peter
name: Schneider, Alexandra
name: Bolte, Gabriele
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 313

description: Recently, attention has been drawn to the need to integrate sex/gender more comprehensively into environmental health research. Considering theoretical approaches, we define sex/gender as a multidimensional concept based on intersectionality. However, operationalizing sex/gender through multiple covariates requires the usage of statistical methods that are suitable for handling such complex data. We therefore applied two different decision tree approaches: classification and regression trees (CART) and conditional inference trees (CIT). We explored the relevance of multiple sex/gender covariates for the exposure to green spaces, measured both subjectively and objectively. Data from 3742 participants from the Cooperative Health Research in the Region of Augsburg (KORA) study were analyzed within the INGER (Integrating gender into environmental health research) project. We observed that the participants’ financial situation and discrimination experience was relevant for their access to high quality public green spaces, while the urban/rural context was most relevant for the general greenness in the residential environment. None of the covariates operationalizing the individual sex/gender self-concept were relevant for differences in exposure to green spaces. Results were largely consistent for both CART and CIT. Most importantly we showed that decision tree analyses are useful for exploring the relevance of multiple sex/gender dimensions and their interactions for environmental exposures. Further investigations in larger urban areas with less access to public green spaces and with a study population more heterogeneous with respect to age and social disparities may add more information about the relevance of multiple sex/gender dimensions for the exposure to green spaces.
FACTORS AFFECTING STUDENTS' ATTITUDE TOWARDS ENTREPRENEURSHIP፡ THE CASE OF ADDIS ABABA SCIENCE AND TECHNOLOGY UNIVERSITY GRADUATING STUDENTS
Creators: name: WALLELIGN WONDIE ABEBE
Publisher: name: Zenodo
Year: 2020

description: The objective of this study was to examine factors affecting graduating students’ attitude towards entrepreneurship: the case of Addis Ababa Science and Technology University undergraduate and postgraduate students. The primary challenge of higher education students is securing a job after graduation. Furthermore, there is no established mindset among the students as to how to go about translating their academic gains into innovations that can be commercialized. The study employed explanatory research design supported with deductive/quantitative approach data was collected with questionnaire and structured interview from graduating class students and university officers. The Taro Yamane (1967) formula sample size determination method was used to determine the sample size and the sample size was 328. The collected data was analyzed using inferential analysis techniques: regression and correlation. The correlation analysis result reported there is strong association among the study variables. From the simple linear regression result, it was found that family background explained 77.9% of the variation in students’ entrepreneurial attitude. The simultaneous multiple regression result reported that 83.6% of the variation in students’ entrepreneurial attitude is explained by the proposed model. Based on these major findings the researcher recommends that family of the students should financially support and morally encourage youth children to enhance their entrepreneurial attitude. The researcher further notes that entrepreneurial government support programs’ should be reachable to the needy young.
The terminal enzymatic step in piperine biosynthesis is co-localized with the product piperine in specialized cells of black pepper (Piper nigrum L.)
Creators: name: Jäckel, Luise
name: Schnabel, Arianne
name: Stellmach, Hagen
name: Klauß, Ulrike
name: Matschi, Susanne
name: Hause, Gerd
name: Vogt, Thomas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 583

description: Piperine (1-piperoyl piperidine) is responsible for the pungent perception of dried black pepper (Piper nigrum) fruits and essentially contributes to the aromatic properties of this spice in combination with a blend of terpenoids. The final step in piperine biosynthesis involves piperine synthase (PS), which catalyzes the reaction of piperoyl CoA and piperidine to the biologically active and pungent amide. Nevertheless, experimental data on the cellular localization of piperine and the complete biosynthetic pathway are missing. Not only co-localization of enzymes and products, but also potential transport of piperamides to the sink organs is a possible alternative. This work, which includes purification of the native enzyme, immunolocalization, laser microdissection, fluorescence microscopy, and electron microscopy combined with liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS), provides experimental evidence that piperine and PS are co-localized in specialized cells of the black pepper fruit perisperm. PS accumulates during early stages of fruit development and its level declines before the fruits are fully mature. The product piperine is co-localized to PS and can be monitored at the cellular level by its strong bluish fluorescence. Rising piperine levels during fruit maturation are consistent with the increasing numbers of fluorescent cells within the perisperm. Signal intensities of individual laser-dissected cells when monitored by LC-ESI-MS/MS indicate molar concentrations of this alkaloid. Significant levels of piperine and additional piperamides were also detected in cells distributed in the cortex of black pepper roots. In summary, the data provide comprehensive experimental evidence of and insights into cell-specific biosynthesis and storage of piperidine alkaloids, specific and characteristic for the Piperaceae. By a combination of fluorescence microscopy and LC-MS/MS analysis we localized the major piperidine alkaloids to specific cells of the fruit perisperm and the root cortex. Immunolocalization of native piperine and piperamide synthases shows that enzymes are co-localized with high concentrations of products in these idioblasts.
Air Separation of Alfalfa Into High and Low Protein Fractions: An Economic Evaluation
Creators: name: Vosloh, Carl J.
name: Kuzmicky, Donald D.
name: Kohler, George O.
name: Enochian, Robert V.
name: Vosloh, Carl J.
name: Kuzmicky, Donald D.
name: Kohler, George O.
name: Enochian, Robert V.
Publisher: name: Unknown
Year: 1974
Subjects: subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics
subject: Research Methods/ Statistical Methods
subject: Alfalfa
subject: dehydrated alfalfa
subject: livestock feeds
subject: feed prices
subject: marketing
subject: linear programming
subject: feed ingredients

description: Five separated dehydrated alfalfa products of different protein levels were evaluated using prices of feed ingredients from four different markets and three different time periods in both poultry and cattle rations. This evaluation shows that in some market situations the economic value of dehydrated alfalfa (dehy) can be increased by separation. The study also describes how the value of separation can be estimated. The method for air separating the light leafy fraction, which is high in protein and low in fiber, from the denser stem fraction, which contains most of the fiber, was developed by the Western Regional Research Center, Agricultural Research Service, USDA. This technique provides the potential for producing dehydrated alfalfa products that can be more efficiently utilized by different livestock classes.
Higher temperature variability in deforested mountain regions impacts the competitive advantage of nocturnal species
Creators: name: Shen, Sheng-Feng
name: Chan, Shih-Fan
name: Rubenstein, Dustin R.
name: Chen, I-Ching
name: Fan, Yu-Meng
name: Zheng, Yuan-Wen
Publisher: name: Zenodo
Year: 2022
Subjects: deforestation
daily temperature fluctuation
daily activity pattern
nocturnal species
interspecific competition
Nicrophorus nepalensis

description: Deforestation is a primary cause of biodiversity loss. However, we know little about its effects on global patterns of daily microclimate variation, which can differentially impact species with different daily activity patterns. Using a recently developed microclimate model, we show that deforestation causes an increase in the diurnal temperature range (DTR) in lowland habitats at low latitudes and the mountains at high latitudes. Furthermore, we investigate competitive interactions between nocturnal burying beetles and all-day active blowfly maggots in forested and deforested habitats in Taiwan. We show that deforestation leads to increased DTR at higher elevations, which enhances the competitiveness of blowfly maggots during the day and leads to a higher failure rate of carcass burial by the nocturnal beetles. Thus, deforestation-induced temperature variability not only modulates exploitative competition between species with different daily activity patterns but also likely exacerbates the negative impacts of climate change on nocturnal organisms.
description: Funding provided by: Academia Sinica
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001869
Award Number: AS-SS-106-05Funding provided by: Minister of Science and Technology of Taiwan*
Crossref Funder Registry ID:
Award Number: 100-2621-B-001-004-MY3Funding provided by: Minister of Science and Technology of Taiwan*
Crossref Funder Registry ID:
Award Number: 104-2311-B-001-028-MY3Funding provided by: Minister of Science and Technology of Taiwan*
Crossref Funder Registry ID:
Award Number: 108-2314-B-001-009-MY3Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: IOS-1656098
Active RhoA exerts an inhibitory effect on the homeostasis and angiogenic capacity of human endothelial cells
Creators: name: Hauke, Michael
name: Eckenstaler, Robert
name: Ripperger, Anne
name: Ender, Anna
name: Braun, Heike
name: Benndorf, Ralf
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 611

description: Background: The small GTPase RhoA (Ras homolog gene family, member A) regulates a variety of cellular processes, including cell motility, proliferation, survival, and permeability. In addition, there are reports indicating that RhoA‐ROCK (rho associated coiled‐coil containing protein kinase) activation is essential for VEGF (vascular endothelial growth factor)‐mediated angiogenesis, whereas other work suggests VEGF‐antagonistic effects of the RhoA‐ROCK axis. Methods and Results: To elucidate this issue, we examined human umbilical vein endothelial cells and human coronary artery endothelial cells after stable overexpression (lentiviral transduction) of constitutively active (G14V/Q63L), dominant‐negative (T19N), or wild‐type RhoA using a series of in vitro angiogenesis assays (proliferation, migration, tube formation, angiogenic sprouting, endothelial cell viability) and a human umbilical vein endothelial cells xenograft assay in immune‐incompetent NOD scid gamma mice in vivo. Here, we report that expression of active and wild‐type RhoA but not dominant‐negative RhoA significantly inhibited endothelial cell proliferation, migration, tube formation, and angiogenic sprouting in vitro. Moreover, active RhoA increased endothelial cell death in vitro and decreased human umbilical vein endothelial cell‐related angiogenesis in vivo. Inhibition of RhoA by C3 transferase antagonized the inhibitory effects of RhoA and strongly enhanced VEGF‐induced angiogenic sprouting in control‐treated cells. In contrast, inhibition of RhoA effectors ROCK1/2 and LIMK1/2 (LIM domain kinase 1/2) did not significantly affect RhoA‐related effects, but increased angiogenic sprouting and migration of control‐treated cells. In agreement with these data, VEGF did not activate RhoA in human umbilical vein endothelial cells as measured by a Förster resonance energy transfer–based biosensor. Furthermore, global transcriptome and subsequent bioinformatic gene ontology enrichment analyses revealed that constitutively active RhoA induced a differentially expressed gene pattern that was enriched for gene ontology biological process terms associated with mitotic nuclear division, cell proliferation, cell motility, and cell adhesion, which included a significant decrease in VEGFR‐2 (vascular endothelial growth factor receptor 2) and NOS3 (nitric oxide synthase 3) expression. Conclusions: Our data demonstrate that increased RhoA activity has the potential to trigger endothelial dysfunction and antiangiogenic effects independently of its well‐characterized downstream effectors ROCK and LIMK.
Do the Fix Ingredients Already Exist? An Empirical Inquiry into the Redundancy Assumptions of Program Repair Approaches
Creators: name: Martinez, Matias
name: Weimer, Westley
name: Monperrus, Martin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Much initial research on automatic program repair has focused on experimental results to probe their potential to find patches and reduce development effort. Relatively less effort has been put into understanding the hows and whys of such approaches. For example, a critical assumption of the GenProg technique is that certain bugs can be fixed by copying and re-arranging existing code. In other words, GenProg assumes that the fix ingredients already exist elsewhere in the code. In this paper, we formalize these assumptions around the concept of ''temporal redundancy''. A temporally redundant commit is only composed of what has already existed in previous commits. Our experiments show that a large proportion of commits that add existing code are temporally redundant. This validates the fundamental redundancy assumption of GenProg.
description: ICSE - 36th IEEE International Conference on Software Engineering (2014)
Association between usual dietary intake of food groups and DNA methylation and effect modification by metabotype in the KORA FF4 cohort
Creators: name: Hellbach, Fabian
name: Baumeister, Sebastian E.
name: Wilson, Rory
name: Wawro, Nina
name: Dahal, Chetana
name: Freuer, Dennis
name: Hauner, Hans
name: Peters, Annette
name: Winkelmann, Juliane
name: Schwettmann, Lars
name: Rathmann, Wolfgang
name: Kronenberg, Florian
name: Koenig, Wolfgang
name: Meisinger, Christa
name: Waldenberger, Melanie
name: Linseisen, Jakob
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Associations between diet and DNA methylation may vary among subjects with different metabolic states, which can be captured by clustering populations in metabolically homogenous subgroups, called metabotypes. Our aim was to examine the relationship between habitual consumption of various food groups and DNA methylation as well as to test for effect modification by metabotype. A cross-sectional analysis of participants (median age 58 years) of the population-based prospective KORA FF4 study, habitual dietary intake was modeled based on repeated 24-h diet recalls and a food frequency questionnaire. DNA methylation was measured using the Infinium MethylationEPIC BeadChip providing data on >850,000 sites in this epigenome-wide association study (EWAS). Three metabotype clusters were identified using four standard clinical parameters and BMI. Regression models were used to associate diet and DNA methylation, and to test for effect modification. Few significant signals were identified in the basic analysis while many significant signals were observed in models including food group-metabotype interaction terms. Most findings refer to interactions of food intake with metabotype 3, which is the metabotype with the most unfavorable metabolic profile. This research highlights the importance of the metabolic characteristics of subjects when identifying associations between diet and white blood cell DNA methylation in EWAS.
Economic Impact of Controlling Surface Water Runoff from U.S. Dairy Farms
Creators: name: Buxton, Boyd M.
name: Ziegler, Stephen J.
name: Buxton, Boyd M.
name: Ziegler, Stephen J.
Publisher: name: Unknown
Year: 1974
Subjects: subject: Environmental Economics and Policy
subject: Livestock Production/Industries
subject: Production Economics
subject: Dairy
subject: animal waste
subject: pollution
subject: runoff control
subject: economic impact
subject: industry
subject: investment costs

description: U.S. dairy farmers will soon be faced with Environmental Protection Agency waste control regulations. This study estimated the investment and annual costs they will incur for lot runoff control and solid waste storage systems. Findings indicate that total investment for facilities and equipment to control lot runoff for typical dairy farms, assuming all U.S. dairy producers have lot discharge problems, would be $780 million. An estimated 40 percent of the dairy producers actually have problems. This would represent an aggregate investment of $312 million. EPA regulations will fall heaviest on dairy farms with fewer than 20 cows, where investment could be almost $200 per cow and the cost of producing 100 pounds of milk could increase by 45 cents. Exempting these small producers from compliance would reduce total investment to $528 million, assuming all producers have lot discharge problems. It is expected that runoff control regulations will hasten the exit of small dairy producers and stimulate the current shift to fewer and larger farms.
title: Synthesis and Properties of Vinylogous 6-(Cyclopentadienyl)pentafulvenes
Creators: name: Eiermann, Matthias
name: Stowasser, Bernd
name: Hafner, Klaus
name: Bierwirth, Klaus
name: Frank, Anette
name: Lerch, Alexander
name: Reußwig, Jürgen
Publisher: name: Wiley
Year: 2022

description: The application of the principle of kinetic stabilization on vinylogous 6-(cyclopentadienyl)pentafulvenes 1 led to the synthesis of the di- and tetra-tert-butyl derivatives 7a – e and 8a - c. Their reactions with bases and acids form charged, heteroatom-free cyanine-type carbanionic 9a - e, 10a – e and carbocationic 11a – e, 12a – c species which were characterized with NMR and UV/Vis spectroscopy. Conclusions on the ion pair structures of the alkali metal salts 9a - e and 10a – c are drawn from the spectroscopic data. Additionally, in one case the behavior of the alkali metal salt 10b towards oxidants was studied by cyclic voltammetry and the structure of the corresponding hydrocarbon 8b was proved by X-ray structural analysis.
Educational policies matter : how schooling strategies influence refugee adolescents' school participation in lower secondary education in Germany
Creators: name: Will, Gisela
name: Becker, Regina
name: Winkler, Oliver
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 371

description: This article investigates the educational participation of refugee adolescents in Germany as a main European destination country of refugee migration. Opportunities and restrictions for school participation vary not only across countries–, but in the case of the Federal Republic of Germany, also within countries. The influence of different regional educational policies on refugees' educational participation and the extent to which they limit or enable individual agency, are however, widely understudied. We thus aim to analyze how different regional educational policies within Germany influence refugee students' educational participation regarding four central indicators: the duration until school enrollment, the type of class attended (newcomer vs. regular class), the type of school attended, and whether they are enrolled in settings appropriate for their age. We rely on a theoretical model which sees educational decisions as the result of rational cost-benefit calculations. The individual educational investments depend on individual motivations and resources within a given opportunity structure. We integrate the legal regulations via the opportunity structures into the theoretical model. Our analyses are based on data from 2,415 adolescents who were interviewed in the “ReGES–Refugees in the German Educational System” study. Our results show significant correlations between different regional educational policies and the four domains of educational participation. These effects remain stable when considering family and individual resources, as well as further control variables that previous research on social and ethnic educational inequality has shown to be relevant. Family and individual resources only partially influence educational participation. This indicates that refugee students and their parents have only limited options for action concerning their educational participation. Thus, our study shows that educational policies in fact matter: the assignment to a federal state plays a significant role in determining the duration until school enrollment, whether one is placed to a grade level age-appropriately, and whether one attends a newcomer class. Most significantly, legal regulations strongly influence refugees' chances of attending a higher school track (Gymnasium). Due to the low permeability of the German education system, this creates path dependencies for the further education and career paths of new immigrant students.
Developments in Marketing Spreads for Agricultural Products
Creators: name: Economic Research Service
name: Economic Research Service
Publisher: name: Unknown
Year: 1975
Subjects: subject: Demand and Price Analysis
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics
subject: Price spreads
subject: food marketing
subject: costs

description: Reflecting strong inflationary forces in the economy, charges for processing and distributing food products rose an extraordinary amount in 1974 and accounted for most of the rise in retail food prices. These food marketing charges, as measured by the spread between the retail cost and farm value of a market basket of farm foods, rose 20 percent in 1974, three times greater than any previous annual rise. Returns to farmers for commodities equivalent to market basket foods averaged 6 percent higher than in 1973. The retail cost of the market basket rose 14 percent. Estimates of cost and profit components of margins for 22 foods reveal that labor and packaging account for the largest share of the processing and retailing margins for most products.
The sensilla-specific expression and subcellular localization of SNMP1 and SNMP2 reveal novel insights into their roles in the antenna of the desert locust Schistocerca gregaria
Creators: name: Cassau, Sina
name: Sander, Doreen
name: Karcher, Thomas
name: Laue, Michael
name: Hause, Gerd
name: Breer, Heinz
name: Krieger, Jürgen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 595

description: Insect olfactory sensilla house olfactory sensory neurons (OSNs) and supports cells (SCs). The olfactory sensory processes require, besides the odorant receptors (ORs), insect-specific members of the CD36 family, named sensory neuron membrane proteins (SNMPs). While SNMP1 is considered to act as a coreceptor in the OR-mediated detection of pheromones, SNMP2 was found to be expressed in SCs; however, its function is unknown. For the desert locust, Schistocerca gregaria, we previously visualized mRNA for SNMP1 in OSNs and SNMP2 mRNA in cells associated with OSN clusters. Towards an understanding of their functional implication, it is imperative to explore the cellular and the subcellular localization the SNMP proteins. Therefore, we have generated polyclonal antibodies against SNMP1 and SNMP2 and used fluorescence immunohistochemistry (FIHC) to visualize the SNMP proteins. We found SNMP1 in the somata and respective dendrites of all OSNs in trichoid sensilla and in subsets of OSNs in basiconic sensilla. Notably, SNMP1 was also detected in SCs of these sensilla types. In contrast, SNMP2 protein was only visualized in SCs of basiconic and coeloconic sensilla, but not of trichoid sensilla. Exploring the subcellular localization by electron microscopy using anti-SNMP1-ab and anti-SNMP2-ab revealed an immunogold labelling of SC microvilli bordering the sensillum lymph. Together our findings suggest a dual role of SNMP1 in the antenna of S. gregaria, in some OSN subpopulations in odor detection as well as in functions of some SCs, whereas the role of SNMP2 is limited to the functions of support cells.
On the connectedness of planar self-affine sets
Creators: name: Liu, Jing-Cheng
name: Luo, Jun Jason
name: Xie, Heng-Wen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: General Topology (math.GN)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In this paper, we consider the connectedness of planar self-affine set $T(A,\mathcal{D})$ arising from an integral expanding matrix $A$ with characteristic polynomial $f(x)=x^2+bx+c$ and a digit set $\mathcal{D}=\{0,1,\dots, m\}v$. The necessary and sufficient conditions only depending on $b,c,m$ are given for the $T(A,\mathcal{D})$ to be connected. Moreover, we also consider the case that ${\mathcal D}$ is non-consecutively collinear.
description: 18 pages; 18 figures
Interpenetrating Polymerization of Styrene in Polypropylene and Poly(Ethylene Terephthalate) Using Microwave Irradiation
Creators: name: Peerasak Paoprasert
Publisher: name: Thammasat University
Year: 2018
Subjects: interpenetrating polymer
poly(ethylene terephthalate)
polypropylene
polystyrene
microwave irradiation

description: Thai Journal of Science and Technology, 7, 6, 567-580
Modulating the fibrillization of parathyroid-hormone (PTH) peptides : azo-switches as reversible and catalytic entities
Creators: name: Paschold, André
name: Voigt, Bruno
name: Hause, Gerd
name: Kohlmann, Tim
name: Rothemund, Sven
name: Binder, Wolfgang H.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 540

description: We here report a novel strategy to control the bioavailability of the fibrillizing parathyroid hormone (PTH)-derived peptides, where the concentration of the bioactive form is controlled by an reversible, photoswitchable peptide. PTH1–84, a human hormone secreted by the parathyroid glands, is important for the maintenance of extracellular fluid calcium and phosphorus homeostasis. Controlling fibrillization of PTH1–84 represents an important approach for in vivo applications, in view of the pharmaceutical applications for this protein. We embed the azobenzene derivate 3-{[(4-aminomethyl)phenyl]diazenyl}benzoic acid (3,4′-AMPB) into the PTH-derived peptide PTH25–37 to generate the artificial peptide AzoPTH25–37 via solid-phase synthesis. AzoPTH25–37 shows excellent photostability (more than 20 h in the dark) and can be reversibly photoswitched between its cis/trans forms. As investigated by ThT-monitored fibrillization assays, the trans-form of AzoPTH25–37 fibrillizes similar to PTH25–37, while the cis-form of AzoPTH25–37 generates only amorphous aggregates. Additionally, cis-AzoPTH25–37 catalytically inhibits the fibrillization of PTH25–37 in ratios of up to one-fifth. The approach reported here is designed to control the concentration of PTH-peptides, where the bioactive form can be catalytically controlled by an added photoswitchable peptide.
Techniques to treat the continuum applied to electromagnetictransitions in $^8$Be
Creators: name: Garrido, E.
name: Jensen, A. S.
name: Fedorov, D. V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Bremsstrahlung emission in collisions between charged nuclei is equivalent to nuclear gamma decay between continuum states. The way the continuum spectrum can be treated is not unique, and efficiency and accuracy of cross section calculations depend on the chosen method. In this work we describe, relate, and compare three different methods in practical calculations of inelastic cross sections, that is, by (i) treating the initial and final states as pure continuum states on the real energy axis, (ii) discretizing the continuum states on the real energy axis with a box boundary condition, and (iii) complex rotation of the hamiltonian(complex scaling method). The electric quadrupole transitions, $2^+ \rightarrow 0^+$ and $4^+ \rightarrow 2^+$, in $α+α$ scattering are taken as an illustration.
description: To be published in Few-body Systems
THE ATTITUDES OF STUDEHTS, PAREHTS AHD TEACHERS roWARDS THE PROHO'I'IOH AHD PRDVISIOH OF OOHDOHS FOR ADOLESCEHTS IH ADDIS ABABA
Creators: name: FISSEHA ESHETU
Publisher: name: Zenodo
Year: 1994

description: A cross-sectional descriptive survey through a selfadministered,

anonymous and structured questionnaire was conducted

from September to December, 1993 in ten high schools in Addis Ababa

to determine the sexual behaviour of adolescents, their knowledge

about AIDS, attitudes and practices regarding condoms, their

attitudes towards the promotion and distribution of condoms in

schools, and towards the incorporation of health and sex education

into the regular teaching curricula and into the teachers' training

curricula.