cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Efficient simulation strategy to design a safer motorcycle
Creators: name: Maier, Steffen
name: Fehr, Jörg
Publisher: name: Universität Stuttgart
Year: 2023
Subjects: subject: 620

description: This work presents models and simulations of a numerical strategy for a time and cost-efficient virtual product development of a novel passive safety restraint concept for motorcycles. It combines multiple individual development tasks in an aggregated procedure. The strategy consists of three successive virtual development stages with a continuously increasing level of detail and expected fidelity in multibody and finite element simulation environments. The results show what is possible with an entirely virtual concept study - based on the clever combination of multibody dynamics and nonlinear finite elements - that investigates the structural behavior and impact dynamics of the powered two-wheeler with the safety systems and the rider’s response. The simulations show a guided and controlled trajectory and deceleration of the motorcycle rider, resulting in fewer critical biomechanical loads on the rider compared to an impact with a conventional motorcycle. The numerical research strategy outlines a novel procedure in virtual motorcycle accident research with different levels of computational effort and model complexity aimed at a step-by-step validation of individual components in the future.
A Precise Synthetic Toolbox: H-Bond-Assisted Quadruple Reactivity of o-Dimethylaminoaryloximes
Creators: name: Tsybulin, Semyon V.
name: Meshalkin, Stepan A.
name: Tonkoglazova, Daria I.
name: Bardakov, Victor G.
name: Pozharskii, Alexander F.
name: Antonov, Alexander S.
Publisher: name: Universität Regensburg
Year: 2025
Subjects: subject: Chemical reactions; Ketones; Nitrogen compounds; Reactivity; Substituents
subject: 540 Chemie

description: Non-covalent interactions are a highly promising tool for the development of transition-metal-free chemospecific synthetic transformations. Here, we demonstrate the implementation of non-covalent interactions as a simple, precise, and flexible synthetic toolbox, allowing the controlled transformation of o-dimethylaminoaryloximes into nitriles and hard-to-reach nitrogen heterocycles under mild conditions. This diverse reactivity is activated via hydrogen bonding and facilitated via the “buttressing effect” of the substituents next to the NMe2 group. All transformations require only simple and easily available acids and solvents, which generally provide precise control over the direction of the reaction, allowing the selective synthesis of nitriles, fused pyrazoles, isoxazoles, and pyrroles.
Brief on the Role of Psychologists in Residential and Home Care Services for Older Adults
Creators: name: Davison, Tanya
name: Koder, Deborah
name: Helmes, Edward
name: Doyle, Colleen
name: Bhar, Sunil
name: Mitchell, Leander
name: Hunter, Carol
name: Knight, Bob
name: Pachana, Nancy
Publisher: name: Swinburne
Year: 2024

description: Objective: This brief examines the evidence that is currently available to inform the provision of psychological services within aged care services, considering both residential care and home care settings. Method: A narrative literature review of the literature evaluating psychological approaches for common conditions in aged care settings was conducted, focusing on the assessment and treatment of common mental health disorders and dementia. Information on the current employment and training of Australian psychologists in geropsychology was also summarised. Results: While further research is required, existing literature provides a clear rationale for the benefit of psychological approaches to address a range of conditions, including the management of dementia. There is only limited research focusing specifically on the home care setting, despite the increasing number of older adults who receive aged care services in their own homes. The current provision of psychological services in Australia is critically low, driven in part by funding limitations. Meanwhile, substantial gaps remain in the training provided to provisional psychologists. Conclusion: A number of key recommendations are made to address the growing need for age-specific psychological assessments and interventions to be included as part of the delivery of aged care services in this country. Given the continued high prevalence of mental health disorders and dementia within aged care settings, as well as even higher rates of subthreshold conditions, improved access to psychological services for older Australians must become a priority.
Higher soluble CD14 levels are associated with lower visuospatial memory performance in youth with HIV.
Creators: name: Loop, Matthew Shane
name: Kim-Chang, Julie J
name: Sleasman, John W
name: Garvie, Patricia A
name: Hong, Suzi
name: Fischer, Bernard
name: Kohn, Jordan
name: Rendina, H Jonathon
name: Venturi, Guglielmo
name: Nichols, Sharon L
name: Woods, Steven P
name: Goodenow, Maureen M
name: Donovan, Kevin
name: Adolescent Medicine Trials Network for HIV/AIDS Interventions
Publisher: name: Wolters Kluwer
Year: 2019

description: OBJECTIVE: HIV-associated neurocognitive disorders persist despite early antiretroviral therapy (ART) and optimal viral suppression. We examined the relationship between immunopathogenesis driven by various pathways of immune activation and discrete neurocognitive performance domains in youth with HIV (YWH). DESIGN: Observational cross-sectional study. METHODS: YWH, ages 20-28 years, enrolled in Adolescent Medicine Trials Network 071/101 were assessed for biomarkers of macrophage, lymphocyte activation, and vascular inflammation using ELISA/multiplex assays. Standardized neurocognitive tests were performed, and demographically adjusted z-scores were combined to form indices of attention, motor, executive function, verbal, and visuospatial memory. Cross-sectional analysis of the relationship between 18 plasma inflammatory biomarkers and each neurocognitive domain was performed. Linear regression models were fit for each combination of log-transformed biomarker value and neurocognitive domain score, and were adjusted for demographics, socioeconomic status, substance use, depression, CD4 T-cell count, HIV viral load, and ART status. RESULTS: Study included 128 YWH [mean age 23.8 (SD 1.7) years, 86% men, 68% African American]. Verbal and visuospatial memory domains were most significantly impaired in the cohort (z=-1.59 and -1.0, respectively). Higher sCD14 was associated with impaired visuospatial memory, which remained robust after adjusting for other biomarkers, demographics, and HIV-associated covariates. Among biomarkers of vascular inflammation, sICAM-1 was negatively associated with verbal memory and attention, whereas sVCAM-1 was positively associated with executive function and visuospatial memory. Specific neurocognitive domains were not associated with sCD163, LPS, or CCL2 levels. CONCLUSION: Impaired visuospatial memory in YWH is associated with immune activation, as reflected by higher sCD14.
Additional file 1 of Black men’s awareness of peripheral artery disease and acceptability of screening in barbershops: a qualitative analysis
Creators: name: Coy, Tyler
name: Brinza, Ellen
name: DeLozier, Sarah
name: Gornik, Heather L.
name: Webel, Allison R.
name: Longenecker, Christopher T.
name: White Solaru, Khendi T.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. HyPe The Cure Exit Interview Guide.
Supplemental material for Physician compliance with quality and patient safety regulations: The role of perceived enforcement approaches and commitment
Creators: name: Weske, Ulrike
name: Boselie, Paul
name: Rensen, Elizabeth Van
name: Schneider, Margriet
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental Material for Physician compliance with quality and patient safety regulations: The role of perceived enforcement approaches and commitment by Ulrike Weske, Paul Boselie, Elizabeth van Rensen and Margriet Schneider in Health Services Management Research
Telementoring_of_Surgeons_-_Supp_Mat_1 – Supplemental material for Telementoring of Surgeons: A Systematic Review
Creators: name: Erridge, Simon
name: Yeung, Derek K. T.
name: Hitendra R. H. Patel
name: Purkayastha, Sanjay
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, Telementoring_of_Surgeons_-_Supp_Mat_1 for Telementoring of Surgeons: A Systematic Review by Simon Erridge, Derek K. T. Yeung, Hitendra R. H. Patel and Sanjay Purkayastha in Surgical Innovation
Hesitancy, reactogenicity and immunogenicity of the mRNA and whole-virus inactivated Covid-19 vaccines in pediatric neuromuscular diseases
Creators: name: Yu, Michael Kwan Leung
name: Chan, Sophelia Hoi Shan
name: Cheng, Samuel
name: Leung, Daniel
name: Chan, Sau Man
name: Yan, Amy Suen Ka
name: Wong, Wilfred Hing Sang
name: Peiris, Malik
name: Lau, Yu Lung
name: Duque, Jaime S Rosa
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The mRNA-based BNT162b2 and inactivated whole-virus CoronaVac are two widely used COVID-19 vaccines that confer immune protection to healthy individuals. However, hesitancy toward COVID-19 vaccination appeared to be common for patients with neuromuscular diseases (NMDs) due to the paucity of data on the safety and efficacy in this high-risk patient population. Therefore, we examined the underlying factors associated with vaccine hesitancy across time for NMDs and assessed the reactogenicity and immunogenicity of these two vaccines. Patients aged 8–18 years with no cognitive delay were invited to complete surveys in January and April 2022. Patients aged 2–21 years were enrolled for COVID-19 vaccination between June 2021 and April 2022, and they recorded adverse reactions (ARs) for 7 days after vaccination. Peripheral blood was obtained before and within 49 days after vaccination to measure serological antibody responses compared to healthy children and adolescents. Forty-one patients completed vaccine hesitancy surveys for both timepoints, while 22 joined the reactogenicity and immunogenicity arm of the study. Two or more family members vaccinated against COVID-19 was positively associated with intention of vaccination (odds ratio 11.7, 95% CI 1.81–75.1, p = .010). Pain at the injection site, fatigue, and myalgia were the commonest ARs. Most ARs were mild (75.5%, n = 71/94). All 19 patients seroconverted against the wildtype SARS-CoV-2 after two doses of either vaccine, similar to 280 healthy counterparts. There was lower neutralization against the Omicron BA.1 variant. BNT162b2 and CoronaVac were safe and immunogenic for patients with NMDs, even in those on low-dose corticosteroids.
HIV self-testing and STI self-collection via mobile apps: experiences from two pilot randomized controlled trials of young men who have sex with men
Creators: name: Liu, Albert
name: Horvitz, Casey
name: Dormitzer, Julian
name: Mayer, Kenneth H.
name: Bojan, Kelly
name: Biello, Katie B.
name: Emmanuel, Patricia
name: iTech Team
name: Buchbinder, Susan
name: Hightow-Weidman, Lisa
name: Coleman, Kenneth
name: Norelli, Jenna
name: Mullin, Shelby
name: Mimiaga, Matthew J.
name: Sullivan, Patrick
name: Scott, Hyman
name: Futterman, Donna
Publisher: name: AME Publishing Company
Year: 2021

description: BACKGROUND: Young men who have sex with men (YMSM) are disproportionately impacted by HIV and other sexually transmitted infections (STIs) in the United States (US) and have low rates of HIV/STI testing. Provision of HIV self-testing and STI self-collection can increase testing rates, and access to these kits through mobile applications (apps) could help facilitate YMSM using HIV self-testing and STI self-collection. METHODS: Data for this study comes from two pilot randomized controlled trials (RCTs) of mobile apps within the Adolescent Trials Network-LYNX and MyChoices-aimed to increase HIV/STI testing among YMSM (age 15-24) who had not recently tested for HIV and were at high risk for HIV acquisition across five US cities. Both apps include the ability to order a HIV self-test with rapid results and a kit for STI self-collection and mailing of samples for syphilis, gonorrhea and chlamydia to a lab for testing. Using assessments of app users (n=80) at pre-randomization and at 3- and 6-months post-randomization and online interview data from a purposive sample of app users (n=37), we report on experiences and lessons learned with HIV self-testing and STI self-collection kits ordered via the apps. RESULTS: Participants were on average 20.7 years of age (SD =2.4), and 49% were non-White or multiple race/ethnicity. Sixty-three percent had a prior HIV test. Over half (58%) had a prior STI test, but only 3% had tested within the past 3 months. Nearly two-thirds ordered an HIV self-testing kit; of whom, 75% reported using at least one self-test kit over the study period. STI self-collection kit ordering rates were also high (54%); however, STI self-collection kit return rates were lower (13%), but with a high positivity rate (5.3%). Both HIV self-testing and STI self-collection kits were highly acceptable, and 87% reported that it was extremely/very helpful to be able to order these kits through the apps. The most common reason for not ordering the HIV/STI kits was preferring to test at a clinic. In interviews, participants expressed feeling empowered by being able to test at home; however, they also raised concerns around STI sample collection. CONCLUSIONS: HIV self-testing and STI self-collection kit ordering via mobile apps is feasible, acceptable and may show promise in increasing testing rates among YMSM. The LYNX and MyChoices apps are currently being tested in a full-scale efficacy trial, and if successful, these innovative mobile apps could be scaled up to efficiently increase HIV/STI testing among youth across the US.
«Nós»: database on a Galician magazine from 1920 to 1935
Creators: name: Gándara Feijóo, Javier
Publisher: name: Zenodo
Year: 2024

description: Database that contains information on the different texts published by Nós: boletín mensual da cultura galega.  This magazine existed between 1920 and 1935, becoming one of the most significant tools for the vindication of Galician cultural identity.
QoS and DLC in IaaSINDIGO-DataCloud
Creators: name: Fuhrmann, Patrick
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: International Symposium on Grids and Clouds 2016, ISGC 2016, Taipai, Taiwan, 13 Mar 2016 - 18 Mar 2016 ; (2016).
Macaroons and dCache … or delegating in a cloudy world
Creators: name: Fuhrmann, Patrick
name: Millar, Paul
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: International Symposium on Grids and Clouds 2016, ISGC 2016, Taipei, Taiwan, 13 Mar 2016 - 18 Mar 2016 ; (2016).
How Are Neighborhood Characteristics Associated With Mental and Physical Functioning Among Older Adults With Radiographic Knee Osteoarthritis?
Creators: name: Fisher, Edwin B.
name: Jordan, Joanne M.
name: Muessig, Kathryn E.
name: Gottfredson, Nisha C.
name: Kowitt, Sarah D.
name: Callahan, Leigh F.
name: Aiello, Allison E.
Publisher: name: Wiley
Year: 2021

description: OBJECTIVE: To examine how neighborhood characteristics are associated with health outcomes among older adults with osteoarthritis. METHODS: In multilevel, cross-sectional, and longitudinal analyses we examined whether 4 neighborhood characteristics were associated with depressive symptoms and reported knee impact scores, and whether the neighborhood characteristics interacted with race/ethnicity among older adults with radiographic knee osteoarthritis (n = 656 for cross-sectional analyses and n = 434 for longitudinal analyses). The data came from the Johnston County Osteoarthritis Project, a prospective cohort study in North Carolina designed to examine risk factors for osteoarthritis. RESULTS: Although few longitudinal associations were found, cross-sectional results suggested that greater perceived neighborhood social cohesion (B = -0.04, P < 0.001) and perceived neighborhood resources for physical activity and walking (B = -0.03, P < 0.001) were associated with fewer depressive symptoms, and that greater perceived neighborhood resources for physical activity and walking were associated with higher (better) knee impact scores (B = 0.48, P = 0.008). We also observed 2 significant interactions among neighborhood characteristics and race/ethnicity related to depressive symptoms (P < 0.01); for African American adults, greater perceived neighborhood resources for physical activity and walking were associated with fewer depressive symptoms (B = -0.03, P < 0.001), but for White adults, greater perceived neighborhood safety was associated with fewer depressive symptoms (B = -0.04, P = 0.003). CONCLUSION: In a sample of older adults with radiographic knee osteoarthritis, neighborhood context mattered, but in nuanced ways. Interventions aiming to improve mental and physical functioning of older adults with knee osteoarthritis can look to this study as evidence for the importance of neighborhood characteristics.
Appendix_A_-_Questions_from_Surveys – Supplemental material for Demystifying trans*+ voice education: The Transgender Singing Voice Conference
Creators: name: Cayari, Christopher
Publisher: name: SAGE Journals
Year: 2018
Subjects: Education

description: Supplemental material, Appendix_A_-_Questions_from_Surveys for Demystifying trans*+ voice education: The Transgender Singing Voice Conference by Christopher Cayari in International Journal of Music Education
Supplemental material for Endovascular treatment of cephalic arch stenosis in brachiocephalic arteriovenous fistulas: A systematic review and meta-analysis
Creators: name: Reuban Toby D’cruz
name: Sze Wai Leong
name: Syn, Nicholas
name: Tiwari, Alok
name: Sannasi, Vikram Vijayan
name: Sidhu, Harvinder Raj Singh
name: Tjun Yip Tang
Publisher: name: SAGE Journals
Year: 2018
Subjects: Cardiology

description: Supplemental material, Supplemental_Material for Endovascular treatment of cephalic arch stenosis in brachiocephalic arteriovenous fistulas: A systematic review and meta-analysis by Reuban Toby D’cruz, Sze Wai Leong, Nicholas Syn, Alok Tiwari, Vikram Vijayan Sannasi, Harvinder Raj Singh Sidhu and Tjun Yip Tang in The Journal of Vascular Access
Global trends in poliomyelitis research over the past 20 years: A bibliometric analysis
Creators: name: Liu, Qi
name: Liu, Ze
name: Huang, Biling
name: Teng, Yuanyuan
name: Li, Mingliu
name: Peng, Shuqin
name: Guo, Hongbin
name: Wang, Min
name: Liang, Jieyu
name: Zhang, Yi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Poliomyelitis is an acute infectious disease caused by poliovirus. This bibliometric analysis aims to examine the status of poliomyelitis research in the past 20 years. Information regarding polio research was obtained from the Web of Science Core Collection database. CiteSpace, VOSviewer, and Excel were used to perform visual and bibliometric analysis with respect to countries/regions, institutions, authors, journals and keywords. A total of 5,335 publications on poliomyelitis were published from 2002 to 2021. The USA was the county with the majority of publications. Additionally, the most productive institution was the Centers for Disease Control and Prevention. Sutter, RW produced the most papers and had the most co-citations. Vaccine was the journal with the most polio-related publications and citations. The most common keywords were mainly about polio immunology research (“polio,” “immunization,” “children,” “eradication” and “vaccine”). Our study is helpful for identifying research hotspots and providing direction for future research on poliomyelitis.
Supplemental material for Convergence of per capita carbon emissions in the Yangtze River Economic Belt, China
Creators: name: Shiwei Yu
name: Hu, Xing
name: Xuejiao Zhang
name: Zhenxi Li
Publisher: name: SAGE Journals
Year: 2018
Subjects: Geography

description: Supplemental Material for Convergence of per capita carbon emissions in the Yangtze River Economic Belt, China by Shiwei Yu, Xing Hu, Xuejiao Zhang and Zhenxi Li in Energy & Environment
Human Immunodeficiency Virus Pre-Exposure Prophylaxis Knowledge, Attitudes, and Self-Efficacy Among Family Planning Providers in the Southern United States: Bridging the Gap in Provider Training
Creators: name: Sales, Jessica M
name: Sheth, Anandi N
name: McCumber, Micah
name: Ramakrishnan, Aditi
name: Powell, Leah
Publisher: name: Oxford University Press (OUP)
Year: 2022

description: Background: Pre-exposure prophylaxis (PrEP) is an effective human immunodeficiency virus (HIV) prevention intervention, but its access and use are suboptimal, especially for women. Healthcare providers provision of PrEP is a key component of the Ending the HIV Epidemic initiative. Although training gaps are an identified barrier, evidence is lacking regarding how to tailor trainings for successful implementation. Title X family planning clinics deliver safety net care for women and are potential PrEP delivery sites. To inform provider training, we assessed PrEP knowledge, attitudes, and self-efficacy in the steps of PrEP care among Title X providers in the Southern United States. Methods: We used data from providers in clinics that did not currently provide PrEP from a web-based survey administered to Title X clinic staff in 18 Southern states from February to June 2018. We developed generalized linear mixed models to evaluate associations between provider-, clinic-, and county-level variables with provider knowledge, attitudes, and self-efficacy in PrEP care, guided by the Consolidated Framework for Implementation Research. Results: Among 351 providers from 193 clinics, 194 (55%) were nonprescribing and 157 (45%) were prescribing providers. Provider ability to prescribe medications was significantly associated PrEP knowledge, attitudes, and self-efficacy. Self-efficacy was lowest in the PrEP initiation step of PrEP care and was positively associated with PrEP attitudes, PrEP knowledge, and contraception self-efficacy. Conclusions: Our findings suggest that PrEP training gaps for family planning providers may be bridged by addressing unfavorable PrEP attitudes, integrating PrEP and contraception training, tailoring training by prescribing ability, and focusing on the initiation steps of PrEP care.
The first detection of the blazar S4 0954+65 at VHE with the MAGIC Telescopes during an exceptionally high optical state
Creators: name: Pedaletti, Giovanna
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: 28th Texas Symposium, Geneva, AT DESY seminar, Switzerland, 13 Dec 2015 - 18 Dec 2015 ; (2016).
dCache - delegated storage Solutions
Creators: name: Mkrtchyan, Tigran
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: International Symposium on Grids and Clouds 2016, ISGC 2016, Taipei, Taiwan, 13 Mar 2016 - 18 Mar 2016 ; (2016).
Improving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions
Creators: name: Swendeman, Dallas
name: Chowdhury, Shrabanti
name: Carcone, April Idalski
name: Starks, Tyrel
name: Brookmeyer, Ron
name: Naar, Sylvie
name: Chapman, Jason
name: Ingram, LaDrea
name: Ghosh, Samiran
name: Stanton, Bonita
name: Comulada, W. Scott
name: Simpson, Kit
name: Ciaranello, Andrea
name: LeGrand, Sara
name: Horvath, Keith J.
name: Hudgens, Michael G.
name: Reback, Cathy J.
Publisher: name: Mary Ann Liebert
Year: 2019

description: Dramatic decreases in HIV transmission are achievable with currently available biomedical and behavioral interventions, including antiretroviral therapy and pre-exposure prophylaxis. However, such decreases have not yet been realized among adolescents and young adults. The Adolescent Medicine Trials Network (ATN) for HIV/AIDS interventions is dedicated to research addressing the needs of youth at high risk for HIV acquisition as well as youth living with HIV. This article provides an overview of an array of efficient and effective designs across the translational spectrum that are utilized within the ATN. These designs maximize methodological rigor and real-world applicability of findings while minimizing resource use. Implementation science and cost-effectiveness methods are included. Utilizing protocol examples, we demonstrate the feasibility of such designs to balance rigor and relevance to shorten the science-to-practice gap and improve the youth HIV prevention and care continua.
Der Alte würfelt nicht - Einsteins Dialog mit Gott
Creators: name: Naumann, Thomas
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: Potsdamer Köpfe, Bildungsforum, Potsdam, University of Potsdam, Germany, 16 Apr 2016 ; (2016).
Implementation challenges and real-world impacts of switching pediatric vaccines: A global systematic literature review
Creators: name: Patikorn, Chanthawat
name: Kategeaw, Warittakorn
name: Perdrizet, Johnna
name: Li, Xiuyan
name: Chaiyakunapruk, Nathorn
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Switching a vaccine for another on a pediatric national immunization program is often done for the betterment of society. However, if poorly implemented, switching vaccines could result in suboptimal transitions with negative effects. A systematic review was conducted to evaluate the existing knowledge from identifiable documents on implementation challenges of pediatric vaccine switches and the real-world impact of those challenges. Thirty-three studies met the inclusion criteria. We synthesized three themes: vaccine availability, vaccination program deployment, and vaccine acceptability. Switching pediatric vaccines can pose unforeseen challenges to health-care systems worldwide and additional resources are often required to overcome those challenges. Yet, the magnitude of the impact, especially economic and societal, was frequently under-researched with variability in reporting. Therefore, an efficient vaccine switch requires a thorough consideration of the added benefits of replacing the existing vaccine, preparation, planning, additional resource allocation, implementation timing, public–private partnerships, outreach campaigns, and surveillance for program evaluation.
First Experimental Characterization of Electron Beams for THz Options at PITZ
Creators: name: Boonpornprasert, Prach
name: Good, J.
name: Gross, M.
name: Huck, H.
name: Isaev, I.
name: Kalantaryan, D.
name: Krasilnikov, M.
name: Lishilin, O.
name: Loisch, G.
name: Malyutin D. Melkumyan, D.
name: Otevrel, M.
name: Pathak, G.
name: Renier, Y.
name: Rublack, T.
name: Stephan, F.
name: Vashchenko, G.
name: Q
name: , Zhao
name: Asova, G.
name: Bakr, M.
name: Hernandez-Garcia, Carlos
name: Rybakov, I.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: 2nd general meeting of the Helmholtz Programme "Matter and Technologies" (MT), Karlsruhe, Germany, 8 Mar 2016 - 10 Mar 2016 ; (2016).
Interim analysis of a phase 1 randomized clinical trial on the safety and immunogenicity of the mRNA-1283 SARS-CoV-2 vaccine in adults
Creators: name: Yassini, Patrick
name: Hutchens, Mark
name: Paila, Yamuna D.
name: Schoch, Lorraine
name: Aunins, Anne
name: Siangphoe, Uma
name: Paris, Robert
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: This interim analysis of an ongoing phase 1 randomized clinical trial evaluated the safety, reactogenicity, and immunogenicity of mRNA-1283, a next-generation SARS-CoV-2 messenger RNA (mRNA)-based vaccine encoding two segments of the spike protein (i.e. receptor binding and N-terminal domains). Healthy adults aged 18–55 years (n = 104) were randomized (1:1:1:1:1) to receive two doses of mRNA-1283 (10, 30, or 100 µg) or mRNA-1273 (100 µg) administered 28 days apart, or a single dose of mRNA-1283 (100 µg). Safety was assessed and immunogenicity was measured by serum neutralizing antibody (nAb) or binding antibody (bAb) responses. At the interim analysis, no safety concerns were identified and no serious adverse events, adverse events of special interest, or deaths were reported. Solicited systemic adverse reactions were more frequent with higher dose levels of mRNA-1283 than with mRNA-1273. At day 57, all dose levels of the 2-dose mRNA-1283 regimen (including the lowest dose level [10 µg]) induced robust nAb and bAb responses that were comparable to those of mRNA-1273 (100 µg). mRNA-1283 was generally safe in adults, with all dose levels of the 2-dose regimen (10, 30, and 100 µg) eliciting similar immunogenicity as the 2-dose mRNA-1273 regimen (100 µg). Clinical Trials Registration: Clinicaltrials.gov, NCT04813796.
Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction
Creators: name: Purvis, Jeremy E.
name: Stanley, Natalie
name: Ranek, Jolene S.
Publisher: name: Springer Nature
Year: 2022

description: Background Current methods for analyzing single-cell datasets have relied primarily on static gene expression measurements to characterize the molecular state of individual cells. However, capturing temporal changes in cell state is crucial for the interpretation of dynamic phenotypes such as the cell cycle, development, or disease progression. RNA velocity infers the direction and speed of transcriptional changes in individual cells, yet it is unclear how these temporal gene expression modalities may be leveraged for predictive modeling of cellular dynamics. Results Here, we present the first task-oriented benchmarking study that investigates integration of temporal sequencing modalities for dynamic cell state prediction. We benchmark ten integration approaches on ten datasets spanning different biological contexts, sequencing technologies, and species. We find that integrated data more accurately infers biological trajectories and achieves increased performance on classifying cells according to perturbation and disease states. Furthermore, we show that simple concatenation of spliced and unspliced molecules performs consistently well on classification tasks and can be used over more memory intensive and computationally expensive methods. Conclusions This work illustrates how integrated temporal gene expression modalities may be leveraged for predicting cellular trajectories and sample-associated perturbation and disease phenotypes. Additionally, this study provides users with practical recommendations for task-specific integration of single-cell gene expression modalities.
Supplemental material for The Pupil Dilation Response to Auditory Stimuli: Current State of Knowledge
Creators: name: Zekveld, Adriana A.
name: Koelewijn, Thomas
name: Kramer, Sophia E.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material for The Pupil Dilation Response to Auditory Stimuli: Current State of Knowledge by Adriana A. Zekveld, Thomas Koelewijn and Sophia E. Kramer in Trends in Hearing
Inferring the structures of signaling motifs from paired dynamic traces of single cells
Creators: name: Haggerty, Raymond A.
name: Purvis, Jeremy E.
Publisher: name: Public Library of Science (PLoS)
Year: 2021

description: Individual cells show variability in their signaling dynamics that often correlates with phenotypic responses, indicating that cell-to-cell variability is not merely noise but can have functional consequences. Based on this observation, we reasoned that cell-to-cell variability under the same treatment condition could be explained in part by a single signaling motif that maps different upstream signals into a corresponding set of downstream responses. If this assumption holds, then repeated measurements of upstream and downstream signaling dynamics in a population of cells could provide information about the underlying signaling motif for a given pathway, even when no prior knowledge of that motif exists. To test these two hypotheses, we developed a computer algorithm called MISC (Motif Inference from Single Cells) that infers the underlying signaling motif from paired time-series measurements from individual cells. When applied to measurements of transcription factor and reporter gene expression in the yeast stress response, MISC predicted signaling motifs that were consistent with previous mechanistic models of transcription. The ability to detect the underlying mechanism became less certain when a cell's upstream signal was randomly paired with another cell's downstream response, demonstrating how averaging time-series measurements across a population obscures information about the underlying signaling mechanism. In some cases, motif predictions improved as more cells were added to the analysis. These results provide evidence that mechanistic information about cellular signaling networks can be systematically extracted from the dynamical patterns of single cells.
Expanding Protection Motivation Theory to explain vaccine uptake among United Kingdom and Taiwan populations
Creators: name: Huang, Po-Ching
name: Chen, I-Hua
name: Barlassina, Luca
name: Turner, James R.
name: Carvalho, Felipe
name: Martinez-Perez, Alvaro
name: Gibson-Miller, Jilly
name: Kürthy, Miklós
name: Lee, Kuo-Hsin
name: Griffiths, Mark D.
name: Lin, Chung-Ying
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Vaccination can sufficiently ameliorate the coronavirus disease-2019 (COVID-19). Investigating what factors influence vaccine uptake may benefit ongoing vaccination efforts (e.g. booster injections, annual vaccination). The present study expanded Protection Motivation Theory with possible factors including perceived knowledge, adaptive responses, and maladaptive responses to develop a proposed model investigating vaccine uptake among United Kingdom (UK) and Taiwan (TW) populations. An online survey collected responses from UK (n = 751) and TW (n = 1052) participants (August to September, 2022). The results of structural equation modeling (SEM) showed that perceived knowledge was significantly associated with coping appraisal in both samples (standardized coefficient [β] = 0.941 and 0.898; p < .001). Coping appraisal was correlated with vaccine uptake only in the TW sample (β = 0.319, p < .05). Multigroup analysis showed there were significant differences between the path coefficients of perceived knowledge to coping and threat appraisals (p < .001), coping appraisal to adaptive and maladaptive responses (p < .001), as well as threat appraisal to adaptive response (p < .001). Such knowledge may improve vaccine uptake in Taiwan. The potential factors for the UK population require further investigation.
Deployment and usage of MCollective in production
Creators: name: Dietrich, Stefan
name: Engels, Jan
name: Sternberger, Sven
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2015

description: HEPiX Spring 2015 at Oxford University, HEPiX Spring 2015, Oxford, Oxford University, UK, 23 Mar 2015 - 27 Mar 2015 ; (2015).
description: Marionette Collective, also known as MCollective, is a framework for building server orchestration, monitoring, and parallel job execution. MCollective uses a modern "Publish Subscribe Middleware" for a scalable and fast execution environment. It is a powerful tool in combination with Puppet, due to the good integration. However it can be a challenging task to configure and deploy MCollective in a reliable and secure way. In this talk, we will give an overview of our DESY MCollective setup, the design decisions, intended use and encountered problems.
Safety and immunogenicity of SCB-2019, an adjuvanted, recombinant SARS-CoV-2 trimeric S-protein subunit COVID-19 vaccine in healthy 12–17 year-old adolescents
Creators: name: Lopez, Pio
name: Bravo, Lulu
name: Buntinx, Erik
name: Borja-Tabora, Charissa
name: Velasquez, Hector
name: Rodriquez, Edith Johana
name: Rodriguez, Camilo A.
name: Carlos, Josefina
name: Montellano, May Emmeline B.
name: Alberto, Edison R.
name: Salvani-Bautista, Milagros
name: Huang, Yung
name: Hu, Branda
name: Li, Ping
name: Han, Htay Htay
name: Baccarini, Carmen
name: Smolenov, Igor
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: We previously demonstrated the efficacy of the COVID-19 vaccine candidate, SCB-2019, in adults in the SPECTRA phase 2/3 efficacy study. We extended the study to include 1278 healthy 12–17-year-old adolescents in Belgium, Colombia, and the Philippines who received either two doses of SCB-2019 or placebo 21 days apart, to assess immunogenicity as neutralizing antibodies against prototype SARS-CoV-2 and variants of concern, and safety and reactogenicity as solicited and unsolicited adverse events with a comparator group of young adults (18–25 years). In participants with no evidence of prior SARS-CoV-2 infection SCB-2019 immunogenicity in adolescents was non-inferior to that in young adults; respective geometric mean neutralizing titers (GMT) against prototype SARS-CoV-2 14 days after the second vaccination were 271 IU/mL (95% CI: 211–348) and 144 IU/mL (116–178). Most adolescents (1077, 84.3%) had serologic evidence of prior SAR-CoV-2 exposure at baseline; in these seropositive adolescents neutralizing GMTs increased from 173 IU/mL (135–122) to 982 IU/mL (881–1094) after the second dose. Neutralizing titers against Delta and Omicron BA SARS-CoV-2 variants were also increased, most notably in those with prior exposure. SCB-2019 vaccine was well tolerated with generally mild or moderate, transient solicited and unsolicited adverse events that were comparable in adolescent vaccine and placebo groups except for injection site pain – reported after 20% of SCB-2019 and 7.3% of placebo injections. SCB-2019 vaccine was highly immunogenic against SARS-CoV-2 prototype and variants in adolescents, especially in those with evidence of prior exposure, with comparable immunogenicity to young adults. Clinical trial registration: EudraCT 2020–004272–17; ClinicalTrials.gov NCT04672395.
Is the association between knee injury and knee osteoarthritis modified by the presence of general joint hypermobility?
Creators: name: Kraus, Virginia B.
name: Cleveland, Rebecca J.
name: Hannan, Marian T.
name: Flowers, Portia P.E.
name: Schwartz, Todd A.
name: Shiue, Kristin Y.
name: Nelson, Amanda E.
name: Golightly, Yvonne M.
name: Jordan, Joanne M.
name: Renner, Jordan B.
name: Hillstrom, Howard J.
name: Goode, Adam P.
Publisher: name: Elsevier
Year: 2020

description: Objective: To evaluate whether joint hypermobility modifies the association between knee joint injury and knee osteoarthritis (OA) among adults. Methods: Data were from three studies: Genetics of Generalized Osteoarthritis (GOGO; N=2,341), Genetics of Osteoarthritis (GO; N=1,872), and the population-based Johnston County Osteoarthritis Project (JoCoOA; N=1,937). Knee injury was defined as a self-report of prior fracture or severe injury to either knee. OA was defined using three variables: knee pain (pain, aching, or stiffness of the knee on most days), radiographic OA (rOA; Kellgren-Lawrence grade 2-4), and symptomatic OA (sxOA; knee rOA with knee pain). Joint hypermobility was defined as Beighton score ≥4. For each study, separate logistic regression models, stratified by joint hypermobility, were used to estimate the association of knee injury with knee pain, rOA, and sxOA, adjusting for age, sex, body mass index, and race (JoCoOA only); statistical interactions between injury and hypermobility were assessed (p-value<0.10). Results: In all three studies, knee injury was associated with OA variables of knee pain, rOA, and sxOA (adjusted odds ratios [aOR] range 1.83-3.75). The association of knee injury with rOA and sxOA was magnified among individuals with vs. without joint hypermobility in GOGO: rOA aOR 11.0, 95% confidence interval [CI] 4.0-30.1 vs. 2.7, 95% CI 2.0-3.6, p=0.009; sxOA aOR 9.2, 95% CI 3.5-24.3 vs. 3.3, 95% CI 2.4-4.4, p=0.032. Interactions were not statistically significant in GO or JoCoOA. Conclusions: In a general adult population, the presence of joint hypermobility may not modify the strong association between knee injury and OA.
Supplemental_Material_C_2018-09-17a_final – Supplemental material for The Bayesian Multilevel Trifactor Item Response Theory Model
Creators: name: Fujimoto, Ken A.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplemental_Material_C_2018-09-17a_final for The Bayesian Multilevel Trifactor Item Response Theory Model by Ken A. Fujimoto in Educational and Psychological Measurement
Meningococcal serogroup B vaccination series initiation in the United States: A real-world claims data analysis
Creators: name: Packnett, Elizabeth R.
name: Zimmerman, Nicole M.
name: Novy, Patricia
name: Morgan, Laura C.
name: Chime, Nnenna
name: Ghaswalla, Parinaz
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: In the United States (US), meningococcal serogroup B (MenB) vaccination has been recommended for 16–23-year-olds (preferably 16–18 years) based on shared clinical decision-making since 2015. MenB vaccine coverage (≥1 dose) by age 17 years has been reported, but initiation at older ages and by insurance type is unknown. In this retrospective cohort study, MarketScan claims data were analyzed to assess MenB vaccine series initiation (i.e. receipt of a first dose) during 2017–2020 among US commercially insured and Medicaid-covered individuals aged 16–18 and 19–23 years. Kaplan–Meier curves were generated to estimate series initiation at various times from index (latest of 1/1/2017 or 16th/19th birthday, depending on the cohort). Multivariable analyses were conducted to identify factors associated with series initiation. Among 1,450,354 Commercial and 1,140,977 Medicaid 16–18-year-olds, MenB vaccine series initiation rates within 3 years of each person’s first eligibility were estimated to be 33% and 20%, respectively; among 1,857,628 Commercial and 747,483 Medicaid 19–23-year-olds, 3% and 1%, respectively. Factors identified to be significantly associated with increased likelihood of initiating a MenB vaccine series included co-administration of meningococcal serogroups ACWY (MenACWY) vaccine, younger age, female sex, nonwhite race (Medicaid only), New England or Middle Atlantic location (Commercial only), urban residence, and previous influenza vaccination. MenB vaccine series initiation among the studied US adolescents and young adults was low. There is a need for continued efforts to better understand barriers to the uptake of vaccines that are recommended based on shared clinical decision-making.
Entwicklung einer Vakuumröhre für einenSpeicherring-Röntgenstrahl-Messplatz
Creators: name: Lindemann, Hendrik
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: Hamburg University of Applied Sciences, Bachelorarbeit, 2016; 86 pp., (2016).
description: Content of this report is the methodical development and construction of a lengthadjustablevacuum tube for scientific experiments. Aim of the development is to optimizethe experiment and to increase the flexibility. To achieve this, specifications are defined.Possible solutions are found with a morphological box. The main points are thetelescopic system, the vacuum bellow and the positioning system. The possible solutionsare compared to each other systematically. The best solution is prepared detailed.Therefore a prize and cost analysis as well as a work safety concept are created. Theflow of forces is checked and involved components are calculated and dimensioned.
Joint Classification and Regression via Deep Multi-Task Multi-Channel Learning for Alzheimer's Disease Diagnosis
Creators: name: Zhang, Jun
name: Liu, Mingxia
name: Adeli, Ehsan
name: Shen, Dinggang
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2018

description: In the field of computer-aided Alzheimer's disease (AD) diagnosis, jointly identifying brain diseases and predicting clinical scores using magnetic resonance imaging (MRI) have attracted increasing attention since these two tasks are highly correlated. Most of existing joint learning approaches require hand-crafted feature representations for MR images. Since hand-crafted features of MRI and classification/regression models may not coordinate well with each other, conventional methods may lead to sub-optimal learning performance. Also, demographic information (e.g., age, gender, and education) of subjects may also be related to brain status, and thus can help improve the diagnostic performance. However, conventional joint learning methods seldom incorporate such demographic information into the learning models. To this end, we propose a deep multi-task multi-channel learning (DM 2L) framework for simultaneous brain disease classification and clinical score regression, using MRI data and demographic information of subjects. Specifically, we first identify the discriminative anatomical landmarks from MR images in a data-driven manner, and then extract multiple image patches around these detected landmarks. We then propose a deep multi-task multi-channel convolutional neural network for joint classification and regression. Our DM 2L framework can not only automatically learn discriminative features for MR images, but also explicitly incorporate the demographic information of subjects into the learning process. We evaluate the proposed method on four large multi-center cohorts with 1984 subjects, and the experimental results demonstrate that DM 2L is superior to several state-of-the-art joint learning methods in both the tasks of disease classification and clinical score regression.