cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
FUNDAMENTALS OF BIOCONVERSION OF BIOREFINERY WASTES TO LIPIDS BY RHODOCOCCUS STRAINS
Creators: name: Li, Xiaolu
Publisher: name: Washington State University
Year: 2022
Subjects: Biofuel
Lignin
Lipid
Non-sugar compounds
Proteomics
Rhodococcus sp.

description: Valorization of lignin-rich biorefinery wastes to biofuels and bioproducts is critical but challenging to improve overall carbon efficiency and facilitate the commercial viability of lignocellulose-based biorefinery. The goal of this dissertation is to understand the fundamentals of bioconversion of lignin and typical non-sugar compounds from biorefinery waste to lipids by Rhodococcus strains. The key contributions of this work include the development of a co-fermentation module employing natural and engineered Rhodococcus strains with significantly improved lignin degradation and/or lipid biosynthesis capacities, which enabled simultaneous conversion of glucose, lignin and its derivatives into lipids. 2D 1H-13C NMR analysis supported the degradation of lignin. Qualitative secretome analysis identified candidate ligninolytic enzymes and accessory oxidases. Global proteome profiles of strains uncovered the ring cleavage of lignin-derived aromatics potentially through a variety of routes to generate central metabolites, including phenylacetic acid pathway, homogentisate pathway and meta-cleavage of catechol, besides widely recognized β-ketoadipate pathway. In addition, R. jostii RHA1 showed excellent catabolic capacity to degrade various non-sugar compounds common in pretreated biomass hydrolysates, including vanillin, vanillate, furfural, 5-hydroxymethylfurfural, and acetate. Distinct utilization efficiency and selective contribution to lipid biosynthesis was observed when different carbon sources were fed. 1H NMR analysis revealed the oxidation pathway of furfural and 5-hydroxymethylfurfural which cannot be fully converted to central metabolites but promoted lipid production from benzoate, suggesting concealed regulatory mechanisms. On the other hand, up-regulation of proteins involved in oxidative stress response and fatty acid metabolism suggested imbalanced cellular redox status and deficiency of reducing power, pointing to a plausible explanation to low lipid yield of lignin conversion. To test this hypothesis, a new mass spectrometry-based proteomics workflow was developed to quantitatively compare protein abundances and redox states in Rhodococcus strains of lignin fermentation to that of glucose. Results showed the prevalence of redox-dependent regulation on metabolic network in response to available carbon sources and cellular redox states. Oxidative stress occurred using lignin as carbon source was proposed as a key barrier to obtain feasible lipid production. These results provide new angles and functional modules for strain metabolic engineering and facilitate the platform design of lignocellulose valorization.
Leptophyes punctatissima Bosc 1792
Creators: name: Monnerat, C.
name: Thorens, P.
name: Walter, T.
name: Gonseth, Y.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Phaneropteridae
Leptophyes
Leptophyes punctatissima

description: Leptophyes punctatissima (Bosc, 1792) Punktierte Zartschrecke LC
description: Published as part of Monnerat C., Thorens P., Walter T. & Gonseth Y., 2007, Rote Liste der Heuschrecken der Schweiz, pp. 1-62 in Umwelt-Vollzug 7 (19) on page 34, DOI: 10.5281/zenodo.270238
title: Vergleichsgruppenwahl in Studien zur zyklischen Ermüdung endodontischer Instrumente: Social Network Analyse zu Legierungen und Herstellern
Creators: name: Herbst, Sascha
name: Krois, Joachim
name: Schwendicke, Falk
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Da die Fraktur endodontischer Instrumente (EI) eine häufige Komplikation während einer Wurzelkanalbehandlungen darstellt, werden EI u.a. auf ihre Widerstandsfähigkeit gegenüber zyklischer Ermüdung (ZE) untersucht. Die vorliegende Arbeit untersuchte[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
How can collaborative coding help your research?
Creators: name: Martinez, Paula
Publisher: name: Zenodo
Year: 2022
Subjects: code
research
pair programming
collaboration
software
benefits

description: This short talk is about the benefits of pair programming. Abstract Let's face it, as researchers, we know that the best outcomes are produced when we collaborate with others. We can gain and share expertise, learn more, and challenge ourselves to improve. Then, why don't we apply the same guidelines of efficient collaboration to writing analysis code? Collaboration is a strategy in which multiple people work together to accomplish a particular goal; the best is that it can be applied to everything we do. Has the thought of 'cross fertilisation between industry and academia' crossed your mind? One of the ground rules of industry development teams is to 'not work alone'. In academia, we tend to work in silos or be solo drivers. In this talk, I will go through the benefits of collaborative coding and show examples of how it would help your research and give you a competitive advantage in the future. ---------------------------------------- Author: Dr Paula Andrea Martinez is the Software Project Coordinator at the Australian Research Data Commons (ARDC). She leads projects that improve the recognition of research software and research software authors. ---------------------------------------- Please cite this presentation: Martinez, Paula Andrea. (2022, November 3). How can collaborative coding help your research?. ResBaz QLD Conference 2022, online. Zenodo. https://doi.org/10.5281/zenodo.7266735 ---------------------------------------- Presentation given at ResBaz QLD 2022
 https://resbaz.github.io/resbaz2022qld/schedule/#session-1055
Reply to: Assessing the precision of morphogen gradients in neural tube development
Creators: name: Vetter, Roman
name: Iber, Dagmar
Publisher: name: arXiv
Year: 2024
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: In a recent article [Vetter and Iber, Nat. Commun. 13, 1145 (2022)], we demonstrated that single morphogen gradients in the developing mouse neural tube can carry sufficient positional accuracy to explain the patterning precision of progenitor domain boundaries. Zagorski et al. had previously concluded otherwise [Zagorski et al., Science 356, 1379-1383 (2017)], based on methodological inconsistencies that we have revealed. The authors now comment on our work with a Matters Arising letter. We rebut their criticism point by point in the Supplement, and summarize the main aspects here.
description: This document supersedes the published version
ANALYZING A GROUP OF DOCTORAL STUDENTS WRITING A RESEARCH PAPER COLLABORATIVELY ONLINE: A CASE STUDY IN A DOCTORAL PROGRAM OF EDUCATION
Creators: name: Segoh, David
Publisher: name: Washington State University
Year: 2022
Subjects: Contradictions
Cultural-Historical Activity Theory
Doctoral student writing group
Online Collaborative Learning Theory
Online collaborative writing
Online mediating tools
Educational technology

description: This dissertation consists of two papers that explore the journey of a writing group by four doctoral students who wanted to publish during their doctoral studies in an educational program at a research-intensive university in the northwest U.S. Using the Online Collaborative Learning Theory (Harasim, 2012) the first paper reveals the occurrences of social discourse and intellectual discourse that occurred when this group decided to collaborate online to try to write a publishable paper from research data originally presented to them by their professor in a course. During their online communication, mainly conducted on Skype chat application, there were clear traces of all the three phases of intellectual discourse, namely idea generating, idea organizing, and intellectual convergence. The group also showed signs of community building, social engagement, and user satisfaction. The transition chapter explains the need to use a more comprehensive theory to better investigate the struggles that the group experienced during their online collaboration and how they used the available online tools. The second study looks at the contradictions that occurred from the beginning the group’s paper was initiated to the moment they decided to meet on Zoom to revise it during summer 2020. Cultural-Historical Activity Theory (CHAT) was utilized to investigate the situation. It was revealed that not only did the group was able to tackle the contradictions throughout the process, but they were also able to reflect on how these contradictions helped shape their experiences as scholarly writers, on how they managed to reconcile with the influences from their interconnecting activity systems, namely their personal lives and their doctoral studies, and on how the online mediating tools had important roles in their efforts to refine and finalize the paper. The final chapter argues that there needs to be more research in online doctoral student writing groups as higher education is becoming more online and there are more and more doctoral programs that demand their students to publish during their studies.
WHEAT GENOTYPE-SPECIFIC RECRUITMENT OF RHIZOSPHERE MICROBIOMES THAT ARE SUPPRESSIVE TO RHIZOCTONIA ROOT ROT
Creators: name: Ermita, Christine Jade Dilla
Publisher: name: Washington State University
Year: 2022
Subjects: subject: Microbiomes
subject: Recruitment
subject: Root rot
subject: Suppression
subject: Wheat
subject: Microbiology
subject: FOS: Biological sciences

description: The soilborne fungal pathogen Rhizoctonia solani AG8 causes root-rot and bare patch disease and is an important disease of wheat especially in the dryland areas of the Pacific Northwest. Despite large scale screening for resistance, resistance is limited in the wheat germplasm. Harnessing suppressive soils with the use of specific wheat genotypes that recruit suppressive rhizosphere microbiomes is a potential alternative in managing the disease. To determine wheat genotype-specific recruitment of microbiomes, growth chamber cycling experiments using six winter wheat genotypes were initially done and suppression assays performed to determine suppression against R. solani AG8. Furthermore, a more diverse wheat panel was assembled for a two-year field cycling experiment to explore more suppressive microbiomes. Disease suppression, observed using field rhizosphere soils, was validated in the growth chamber. PBW343 a spring wheat variety, exhibited more suppressiveness compared with PI561725, a winter wheat breeding line that was identified to have a suppressive microbiome in the initial growth chamber cycling experiment. To identify bacterial taxa that constitute the suppressive microbiome, 16S rRNA sequencing was done and revealed notable abundance of Proteobacteria in more suppressive soils compared to less suppressive soils. Bacterial taxa belonging to Chitinophagaceae, Bradyrhizobiaceae, Rhodospirillaceae, Phyllobacteriaceae, Burkholderiaceae, Caulobacteraceae, Xanthomonadaceae, Glycomycetaceae and Pseudonocardiaceae were differentially more abundant in rhizosphere from PBW343 and were associated with pathogen suppression. Furthermore, bacterial isolation from the rhizosphere soil of PBW343 was done to isolate suppressive bacterial taxa and to determine direct antagonism to the pathogen. Classification of bacterial isolates was done through 16S rRNA amplicon sequencing of colonies and have aided in narrowing down to 13 isolates for antagonism assays. Among the isolates tested, Pseudomonas baetica, Stenotrophomonas maltophilia and Pseudomonas fluorescens significantly inhibited the radial growth of the pathogen. Our research demonstrated that disease suppression elicited by microbiomes are recruited by specific wheat genotypes. With this, specific wheat genotypes can be used to manipulate soil as part of a cropping system to manage root rot and bare patch disease in wheat.
Automated Discovery of Elementary Chemical Reaction Steps Using Freezing String and Berny Optimization Methods
Creators: name: Suleimanov, Yury V.
name: Green, William H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We present a simple protocol which allows fully automated discovery of elementary chemical reaction steps using in cooperation single- and double-ended transition-state optimization algorithms - the freezing string and Berny optimization methods, respectively. To demonstrate the utility of the proposed approach, the reactivity of several systems of combustion and atmospheric chemistry importance is investigated. The proposed algorithm allowed us to detect without any human intervention not only "known" reaction pathways, manually detected in the previous studies, but also new, previously "unknown", reaction pathways which involve significant atom rearrangements. We believe that applying such a systematic approach to elementary reaction path finding will greatly accelerate the possibility of discovery of new chemistry and will lead to more accurate computer simulations of various chemical processes.
Three-dimensional trajectories and network analyses of group behaviour within chimney swift flocks during approaches to the roost
Creators: name: Raja, Sathish K.
name: Ray, Dylan D.
name: Hedrick, Tyson L.
name: Evangelista, Dennis J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Chimney swifts (Chaetura pelagica) are highly manoeuvrable birds notable for roosting overnight in chimneys, in groups of hundreds or thousands of birds, before and during their autumn migration. At dusk, birds gather in large numbers from surrounding areas near a roost site. The whole flock then employs an orderly, but dynamic, circling approach pattern before rapidly entering a small aperture en masse. We recorded the three-dimensional trajectories of ≈1 800 individual birds during a 30 min period encompassing flock formation, circling, and landing, and used these trajectories to test several hypotheses relating to flock or group behaviour. Specifically, we investigated whether the swifts use local interaction rules based on topological distance (e.g. the n nearest neighbours, regardless of their distance) rather than physical distance (e.g. neighbours within x m, regardless of number) to guide interactions, whether the chimney entry zone is more or less cooperative than the surrounding flock, and whether the characteristic subgroup size is constant or varies with flock density. We found that the swift flock is structured around local rules based on physical distance, that subgroup size increases with density, and that there exist regions of the flock that are less cooperative than others, in particular the chimney entry zone.
title: Effektivität von Screening nach Parodontalerkrankungen außerhalb des zahnärztlichen Settings – Ergebnisse eines mehrstufigen Review-Verfahrens mit unterschiedlichen Methoden
Creators: name: Teufer, Birgit
name: Nußbaumer-Streit, Barbara
name: Sommer, Isolde
name: Kien, Christina
name: Affengruber, Lisa
name: Persad, Emma
name: Szelag, Monika
name: Klerings, Irma
name: Bruckmann, Corinna
name: Gartlehner, Gerald
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Die österreichische Vorsorgeuntersuchung (VU) sieht ein Screening nach Parodontalerkrankungen durch einen Fragebogen und eine Inspektion der Mundhöhle durch den Arzt/die Ärztin vor. Internationale Leitlinien sprechen keine Empfehlungen für oder[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Self-similar pattern in coupled parabolic systems as non-equilibrium steady states
Creators: name: Mielke, Alexander
name: Schindler, Stefanie
Publisher: name: Weierstrass Institute
Year: 2023
Subjects: subject: Coupled parabolic systems
subject: reaction-diffusion systems
subject: scaling laws
subject: self-similarity
subject: non-equilibrium steady states
subject: 35C06
subject: 35K40
subject: 35K57
subject: 35K65
subject: 80M30

description: We consider reaction-diffusion systems and other related dissipative systems on unbounded domains which would have a Liapunov function (and gradient structure) when posed on a finite domain. In this situation, the system may reach local equilibrium on a rather fast time scale but the infinite amount of mass or energy leads to persistent mass or energy flow for all times. In suitably rescaled variables the system converges to a steady state that corresponds to asymptotically self-similar behavior in the original system.
Continuous-time Quantum Monte Carlo using Worm Sampling
Creators: name: Gunacker, Patrik
name: Wallerberger, Markus
name: Gull, Emanuel
name: Hausoel, Andreas
name: Sangiovanni, Giorgio
name: Held, Karsten
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a worm sampling method for calculating one- and two-particle Green's functions using continuous-time quantum Monte Carlo simulations in the hybridization expansion (CT-HYB). Instead of measuring Green's functions by removing hybridization lines from partition function configurations, as in conventional CT-HYB, the worm algorithm directly samples the Green's function. We show that worm sampling is necessary to obtain general two-particle Green's functions which are not of density-density type and that it improves the sampling efficiency when approaching the atomic limit. Such two-particle Green's functions are needed to compute off-diagonal elements of susceptibilities and occur in diagrammatic extensions of the dynamical mean field theory and efficient estimators for the single-particle self-energy.
description: 12 pages, 11 figures
Self-Selecting Priority Queues with Burr Distributed Waiting Costs
Creators: name: Kulkarni, Vidyadhar G.
name: Gavirneni, Srinagesh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Service providers, in the presence of congestion and heterogeneity of customer waiting costs, often introduce a fee-based premier option using which the customers self-segment themselves. Examples of this practice are found in health care, amusement parks, government (consular services), and transportation. Using a single-server queuing system with customer waiting costs modeled as a Burr Distribution, we perform a detailed analysis to (i) determine the conditions (fees, cost structure, etc.) under which this strategy is profitable for the service provider, (ii) quantify the benefits accrued by the premier customers; and (iii) evaluate the resulting impact on the other customers. We show that such self-selecting priority systems can be pareto-improving in the sense that they are beneficial to everyone. These benefits are larger when the variance in the customer waiting costs is high and the system utilization is high. We use income data from the poorest and richest areas (identified by zipcode) in the United States along with the countrywide income distribution to illustrate our results. Numerical results indicate that planning for a 20–40% enrollment in the high-priority option is robust in ensuring that all the stakeholders benefit from the proposed strategy.
Additional file 1 of Navigating the ethical complexities of severe and enduring (longstanding) eating disorders: tools for critically reflective practice and collaborative decision-making
Creators: name: Jamieson, Sacha Kendall
name: Tan, Jacinta
name: Piekunka, Kym
name: Calvert, Shannon
name: Anderson, Stephen
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Science Policy
subject: Mental Health

description: Additional file 1.
ARDC IU Federation University RDM Survey 2022
Creators: name: Germaine, Sae Ra
name: Pyers, Emily
Publisher: name: Federation University Australia
Year: 2022
Subjects: Data management and data science not elsewhere classified

description: The Australian Research Data Commons (ARDC) in 2021 commenced the Institutional Underpinnings (IU) project, a collaborative project between 25 of Australia’s universities to develop a shared approach to university research data management in the form of a nationally-agreed framework. During 2021, participating institutions, including Federation University Australia, prioritised and developed an initial series of eight ‘elements’ of such a framework. Phase Two of the IU project (until August 2022) involved the testing of one of more of these elements by each participating University, with Phase Three (August until November 2022) using data from the testing phase to finalise the national framework. Federation University Australia nominated a Phase Two project which would test the Culture Change element through undertaking a Scoping Study to identify current University practices, resources and infrastructure related to research data management, together with developing a plan to implement, achieve and monitor sustainable best practice RDM. This project was undertaken on the University’s behalf by Sae Ra Germaine (Manager of Member and Academic Services) and Emily Pyers (Business Analyst (Metadata & Repositories)) from CAVAL Ltd. One component of this Phase Two Project was a survey of University researchers, with plans for follow up interviews with interested respondents to the Survey. The survey questions above, as well as the proposed interview questions, have been made available for reuse under a CC BY 4.0 licence.
Meconema meridionale Costa 1860
Creators: name: Monnerat, C.
name: Thorens, P.
name: Walter, T.
name: Gonseth, Y.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Meconema
Meconema meridionale

description: Meconema meridionale Costa, 1860 Südliche Eichenschrecke LC In Ausbreitung
description: Published as part of Monnerat C., Thorens P., Walter T. & Gonseth Y., 2007, Rote Liste der Heuschrecken der Schweiz, pp. 1-62 in Umwelt-Vollzug 7 (19) on page 34, DOI: 10.5281/zenodo.270238
title: Effectiveness of treatment sequences for elderly patients with multiple myeloma – a comparison of treatment schedules from clinical trials and experience from the Austrian Myeloma Registry
Creators: name: Rochau, Ursula
name: Vukicevic, Durda
name: Angerer, Silvia
name: Schaffner, Monika
name: Qerimi Rushaj, Vjollca
name: Conrads-Frank, Annette
name: Jahn, Beate
name: Hackl, Werner O.
name: Ammenwerth, Elske
name: Stummer, Harald
name: Garrison, Louis Preston
name: Weger, Roman
name: Willenbacher, Ella
name: Willenbacher, Wolfgang
name: Siebert, Uwe
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: Multiple myeloma (MM) originates from a neoplastic proliferation of plasma cells in the bone marrow. Usually, multiple treatment lines are applied after disease progression [ref:1]. Results from randomized controlled trials evaluating different treatment [for full text, please go to the a.m. URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Full counting statistics of information content in the presence of Coulomb interaction
Creators: name: Utsumi, Yasuhiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We calculate the Rényi entropy of a positive integer order $M$ for a reduced density matrix of a single-level quantum dot connected to left and right leads. We exploit a $2 \times 2$ modified Keldysh Green function matrix obtained by the discrete Fourier transform of a $2 M \times 2M$ multi-contour Keldysh Green function matrix. A moment generating function of self-information is deduced from the analytic continuation of $M$ to the complex plane. We calculate the probability distribution of self-information and find that, within the Hartree approximation, the on-site Coulomb interaction affects rare events and modifies a bound of the probability distribution. A simple equality, from which an upper bound of the average, i.e., the entanglement entropy, would be inferred, is presented. For noninteracting electrons, the entanglement entropy is expressed with current cumulants of the full-counting statistics of electron transport.
description: 15 pages, 8 figures
AN INVESTIGATION OF TAX RISK DISCLOSURES AND ESTIMATION UNCERTAINTY IN SECURITIES AND EXCHANGE COMMISSION ANNUAL REPORTS
Creators: name: axelton, zhuoli zhou
Publisher: name: Washington State University
Year: 2022
Subjects: audit fees
audit report lag
cost of debt
critical accounting policies and estimates
modified audit opinion
risk disclosures

description: This dissertation investigates the incremental effects of uncertain disclosure narratives in annual filings of public companies. In the first essay, I investigate the effects of Form 10-K qualitative tax risk disclosures on the prices of syndicated loans. I find that firms with more extensive tax risk disclosures enjoy lower loan spreads. This effect is more pronounced among firms with higher IRS audit risk and information risk. I also find that tax risk disclosures convey managements’ ability to manage tax risks, as evidenced by lower future tax volatility following the initiation of extensive tax risk disclosures. Consistent with tax risk disclosures enhancing management credibility and providing greater assurance to lenders, I document that these disclosures attenuate the association between tax risk and the cost of debt. My second essay focuses on auditor decisions related to estimation uncertainty in financial reporting. I construct a composite measure of estimation uncertainty that captures the length, the number of estimation-related words, and topical coverage in the critical accounting policies and estimates (CAPEs) portion of Form 10-K filings. I validate this measure by demonstrating its association with earnings attributes linked to measurement uncertainty and lower accrual reliability. Relying on this measure, I investigate the extent that auditors incorporate estimation uncertainty reflected in CAPEs in their risk assessments. I find that auditors charge higher audit fees, take longer to issue audit reports, and are more likely to issue modified audit opinions when CAPE estimation uncertainty is higher. These results are robust to entropy balancing, year-to-year change analysis, and controls for firm fixed effects. When I focus on tax and goodwill estimation uncertainty, I document that estimation uncertainty reflected in CAPEs has incremental effects beyond existing measures of estimates reported in financial statements. I demonstrate the positive association between CAPE estimation uncertainty and the textual properties of critical audit matter (CAM) disclosures, which supports the view that auditors incorporate estimation uncertainty reflected in CAPEs in their risk assessments.
IMPAIRED DEVELOPMENTAL AND METABOLIC PROCESSES WITHIN THE SKELETAL MUSCLE IN RESPONSE TO HIGH-FAT-DIET
Creators: name: Zhao, Liang
Publisher: name: Washington State University
Year: 2022
Subjects: Developmental biology

description: Obesity has become a major health concern due to its close associations with the development of multiple metabolic syndromes. Disruption of the skeletal muscle under the challenge of obesity has severe adverse outcomes on the systematic metabolism. Obesity during the pregnancy impairs the developmental progress in the offspring which predisposes the risks of metabolic disorders later in life. A better understanding of the impairments caused by obesity to the skeletal muscle and the underlying mechanism are urgently needed to help with the prevention of obesity-associated metabolic dysfunctions. In this dissertation, the impairments of obesity to the skeletal muscle were examined both at the embryonic and adult stages. (1) Using single-cell transcriptomic analysis, we found that maternal obesity enhanced a hypoxic state in the mouse embryos at embryonic 9.5 day, accompanied by increased glycolysis, decreased oxidative phosphorylation and elevated oxidative stress. The bone morphogen protein signaling transduction within the dermomyotome was enhanced by maternal obesity, which attenuated the myogenic differentiation by suppressing the expression of an important myogenic regulator, Mef2c. The myogenic inhibitory function of the hypoxia regulator, HIF1A, was achieved through up-regulation of the down-stream effector of Notch signaling, Hes1. Maternal obesity-attenuated myogenic differentiation at the embryonic stage may account for the impairments in muscle growth and function at later lives. (2) Retinoic acid signaling in fibro/adipogenic progenitors was found to facilitate the myofiber regeneration after injury as well as to suppress their ectopic differentiation into adipocytes. Decreased retinoic acid signaling in the skeletal muscle caused by obesity disrupted the physiological functions of fibro/adipogenic progenitors, which resulted in failed muscle repair with enhanced lipid and fibrosis accumulation. (3) AMPKα1 was identified as an important mediator for the beneficial effects of raspberry supplementation on alleviating inflammatory responses and promoting insulin sensitivity in skeletal muscle of obese mice. Taken together, our studies provide us with a better understanding of obesity-induced impairments to the skeletal muscle at both the embryonic and adult stages. Signaling mechanisms identified in these studies provide theoretic supports to the therapeutic treatments of obesity and associated metabolic syndromes.
title: Wie gut sprechen alte Patienten mit einer majoren Depression auf Antidepressiva an: Eine systematische Übersichtsarbeit und Metaanalyse
Creators: name: Krause, Marc
name: Gutsmiedl, Katharina
name: Leucht, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Depressionen sind in der älteren Bevölkerung sehr häufig und führen oft zu einer reduzierten Lebensqualität und im Extremfall zum Tod durch Suizid. Antidepressiva sind die am häufigsten verwendeten Behandlungen. Aufgrund der pharmakokinetischen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
How Inbred is the Tasmanian Devil? A Meta-Analysis of Island Mammals (Sarcophilus harrisii)
Creators: name: Kane, Rachael
Publisher: name: Washington State University
Year: 2022
Subjects: devil facial tumor disease
disease
genetic diversity
inbreeding
population genetics
Sarcophilus harrisii
Conservation biology

description: Island species are vulnerable to extinction due to small population sizes and low genetic diversity, and their declines contribute disproportionately to global biodiversity losses. Despite decades of research studying inbreeding of island species, meta-analyses of relative levels of inbreeding and underlying environmental factors are rare. Such studies can help elucidate generalities regarding the influences on species’ genetic diversity and thereby help direct management toward ecosystem-wide efforts. One type of management strategy entails genetic rescue, or captive breeding or translocations aimed at maintenance or enhancement of genome-wide genetic diversity to facilitate adaptation potential, but recent efforts have begun to focus on targeted maintenance of current adaptive variation in response to specific threats. Endemic to the island of Tasmania, the Tasmanian devil is a species threatened with extinction and the focus of such management efforts. Devils are endangered owing to devil facial tumor disease (DFTD), a transmissible cancer, and historic population bottlenecks and potential inbreeding depression are thought to contribute to near-universal disease susceptibility. Diseased populations have declined more than 80%, elevating further inbreeding risk. Nonetheless, devils have shown rapid evolutionary responses to DFTD suggesting standing genetic diversity is adequate to respond to this intense selective pressure. In this thesis, I assess the overall genetic diversity of the Tasmanian devil pre- and post-DFTD to determine whether significant reductions in genetic diversity in the devil have occurred via DFTD-induced declines. Because current devil management includes genetic rescue, I assess devil genetic diversity relative to other island mammals in a meta-analysis of available literature. I found that the devil has not experienced a significant change in inbreeding or genetic diversity based on pre- and post-DFTD comparison. Relative to other island mammals, devils were intermediate in their inbreeding values. The meta-analysis results were mixed with some relationships aligning with island biogeography theory and some being contradictory. Generally, the meta-analysis provides evidence that distance to mainland, island area, animal mass, and species contribute to genetic diversity or population differentiation in island mammal species. Overall, this thesis provides a contemporary evaluation of island biographic factors and their contribution to genetic diversity estimates and applies a refined assessment of Tasmanian devil genetic diversity that can be used as a framework for future management.
LINEAR MR-BRAKE WITH PERMANENT MAGNET ARRAY
Creators: name: Wang, Ziqi
Publisher: name: Washington State University
Year: 2022
Subjects: Linear Brake
Linear MRB
MR-brake
MRB
Permanent Magnets
PM

description: Currently, MR dampers with electromagnets (EM) are the main type of devices with MR- fluid to provide linear damping and braking forces. The EM devices are simple in structure and easy to control, but consume significant amount of energy and hard to miniaturize. Therefore, use of permanent magnets (PM) in the design of a linear MR-brake (MRB) can be a potential improvement. The main goal of this research was to design and manufacture a compact linear MRB with PMs. A prototype device has been manufactured. Dynamic response, curve following, force profile, hysteresis and control experiments have been conducted. The results indicate that use of PMs in such a linear brake is a viable option as it can lead to a relatively compact device with a large braking force. However, faster response with shorter time constant remains to be improved. This can be achieved using slightly larger motors and with some structural alterations of the design. The device uses only 2.1 J of energy to engage the brake and maintains high damping force with 0 power consumption. A similar brake with EM activation needs up to 1.7 W to keep the same damping force.
title: Netzwerk-Metaanalyse zur Wirksamkeit und Sicherheit von Antidepressiva, Psychotherapie und anderen Behandlungen akut kranker älterer Patienten mit einer majoren Depression
Creators: name: Krause, Marc
name: Gutsmiedl, Katharina
name: Chaimani, Anna
name: Bighelli, Irene
name: Leucht, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Depressionen sind in der älteren Bevölkerung sehr häufig und führen oft zu einer reduzierten Lebensqualität und im Extremfall zum Tod durch Suizid. Antidepressiva sind die am häufigsten verwendeten Behandlungen. Welches Antidepressiva besonders[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
FUNCTIONAL AND IMMUNOLOGICAL CHARACTERIZATION OF CLAMP AND RAP-1 PROTEINS IN THEILERIA EQUI
Creators: name: Onzere, Cynthia
Publisher: name: Washington State University
Year: 2022
Subjects: CLAMP
Equine
Erythrocytes
Invasion
RAP-1
Theileria equi

description: Theileria equi (T. equi) is one of the causative agents of equine piroplasmosis, a severe tick-transmitted disease that affects most equid species. Control of the parasite is impeded by the lack of an effective vaccine and the fact that it can be transmitted by multiple tick vectors. T. equi is classified within the phylum Apicomplexa due to the presence of secretory organelles (micronemes, rhoptries and dense granules) on the apical end of the parasite that are essential for invasion and establishment of apicomplexans within host cells. Unlike most apicomplexan species, the roles of these organelles, and their contents in host cell invasion remain unexplored in T. equi. In chapter one, we evaluate the role of T. equi micronemes by assessing the role of the claudin like apicomplexan microneme protein (CLAMP) in erythrocyte invasion and identify equine erythrocyte components that interact with the protein during cell entry. We also assess expression of CLAMP in the merozoite and intra-erythrocytic developmental stages of T. equi and evaluate its immunogenicity as a potential vaccine candidate. The results show that the protein is expressed in both developmental stages and elicits significant antibody responses in horses during T. equi infection, indicating that it is a viable candidate for vaccine development. The results also show that CLAMP is involved in invasion of equine erythrocytes and the protein interacts with key components of the equine erythrocyte cytoskeleton during cell entry. In chapter two, we evaluate the role of T. equi rhoptries in invasion. In this regard, we assess the expression of the rhoptry associated protein-1a and -1b (RAP-1a and RAP-1b) in the merozoite and intra-erythrocytic developmental stages of T. equi and evaluate their immunogenicity and roles in invasion. Our findings show that both proteins are expressed in both developmental stages and while RAP-1a is highly immunogenic and involved in erythrocyte entry, the N- and C-termini of RAP-1b are not required for cell entry and are not immunogenic. In conclusion, our findings show that like most apicomplexan species, the T. equi secretory organelles are involved in invasion and their contents can be targeted for vaccine development.
Dimensions of treatment quality most valued by adolescent substance users and their caregivers.
Creators: name: Becker, Sara J.
name: Clark, Melissa A.
name: Zeithaml, Valarie A.
name: Spirito, Anthony
name: Midoun, Miriam M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Professional psychologists are increasingly encouraged to document and evaluate the quality of the treatment they provide. However, there is a significant gap in knowledge about the extent to which extant definitions of treatment quality converge with patient perceptions. The primary goal of this study was to examine how adolescent substance users (ASU) and their caregivers perceive treatment quality. The secondary goal was to determine how these perceptions align with expert-derived definitions of ASU treatment quality and dimensions of perceived quality used frequently in other service disciplines. Focus groups and individual interviews were conducted with 24 ASU and 29 caregivers to explore how participants conceptualize a quality treatment experience. Content analysis identified three major dimensions of perceived treatment quality, each of which contained three sub-dimensions: Therapeutic Relationship (i.e., Acceptance, Caring, Connection), Provider Characteristics (i.e., Experience, Communication Skills, Accessibility), and Treatment Approach (i.e., Integrated Care, Use of Structure, and Parent Involvement). Results revealed modest convergence between patient perceptions and existing definitions of quality, with several meaningful discrepancies. Most notably, the Therapeutic Relationship was the most important dimension to ASU and their caregivers, while expert-derived definitions emphasized the Treatment Approach. Implications for practicing psychologists to enhance training and supervision, quality improvement, and health education initiatives are discussed.
Meconema thalassinum De Geer 1773
Creators: name: Monnerat, C.
name: Thorens, P.
name: Walter, T.
name: Gonseth, Y.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Meconema
Meconema thalassinum

description: Meconema thalassinum (De Geer, 1773) Gemeine Eichenschrecke LC
description: Published as part of Monnerat C., Thorens P., Walter T. & Gonseth Y., 2007, Rote Liste der Heuschrecken der Schweiz, pp. 1-62 in Umwelt-Vollzug 7 (19) on page 34, DOI: 10.5281/zenodo.270238
Metrioptera bicolor Philippi 1830
Creators: name: Monnerat, C.
name: Thorens, P.
name: Walter, T.
name: Gonseth, Y.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Metrioptera
Metrioptera bicolor

description: Metrioptera bicolor (Philippi, 1830) Zweifarbige Beissschrecke VU B2b(iii,iv) Grünlandart
description: Published as part of Monnerat C., Thorens P., Walter T. & Gonseth Y., 2007, Rote Liste der Heuschrecken der Schweiz, pp. 1-62 in Umwelt-Vollzug 7 (19) on page 34, DOI: 10.5281/zenodo.270238
Robust Subspace Clustering via Smoothed Rank Approximation
Creators: name: Kang, Zhao
name: Peng, Chong
name: Cheng, Qiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Information Theory (cs.IT)
subject: Machine Learning (cs.LG)
subject: Numerical Analysis (math.NA)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Matrix rank minimizing subject to affine constraints arises in many application areas, ranging from signal processing to machine learning. Nuclear norm is a convex relaxation for this problem which can recover the rank exactly under some restricted and theoretically interesting conditions. However, for many real-world applications, nuclear norm approximation to the rank function can only produce a result far from the optimum. To seek a solution of higher accuracy than the nuclear norm, in this paper, we propose a rank approximation based on Logarithm-Determinant. We consider using this rank approximation for subspace clustering application. Our framework can model different kinds of errors and noise. Effective optimization strategy is developed with theoretical guarantee to converge to a stationary point. The proposed method gives promising results on face clustering and motion segmentation tasks compared to the state-of-the-art subspace clustering algorithms.
description: Journal, code is available
Global production networks and value(s) : lessons from the Chinese soy case
Creators: name: Watt, E
Publisher: name: University Of Tasmania
Year: 2023

description: The influence of globalised food production and consumption on the earth’s resources is being felt more strongly as the ecological consequences of contemporary political-economic structures become ever more threatening. The Chinese Party-State and associated firms are playing a more significant role in existing global governance structures, while also fostering new arrangements such as the Belt and Road Initiative. This dissertation develops a new model for thinking about these structures and their implications. Employing a modified version of the Global Production Networks (GPN) framework, this dissertation investigates the actors, structures and forces that govern the flow of food products into and out of mainland China and shape how ‘value’ is captured. I argue that while the processes of food production and consumption can be understood as occurring through GPNs, the impacts of their operation need to be evaluated through the broader conception of ‘value’ than previously employed. Building on the recent literature on value as a plural concept, the thesis combines GPN and sustainability value (SV) approaches to analyse Chinese firms’ interactions with state and multinational actors in the global soy trade. Through an in-depth case study of soy GPNs it examines the interactions between the Chinese government, Chinese firms and multinational grain corporations in the global soy agrifood supply chain. Soy was chosen as it presents an acute case of many contemporary issues relating to China in global food and agricultural markets; it is critical for industrial meat production, subject to heavy corporate concentration, and has been targetted in the US-China trade wars. Data for the case was collected from academic literature, government announcements and policy documents, company reports, grey literature and statistical data from national governments and international organisations. Based on the investigation, I find that the political economy of food and agriculture in China is a case of centrally managed capitalism where the capitalistic form of production comes under elite control to ensure that marketised production serves national purposes. I also find that there are limitations to this approach to managing the food system and that the current approach leaves China reliant on the global market and vulnerable to its fluctuations. Applying the modified GPN framework to Chinese firms’ overseas operations reveals, pace much popular and academic discourse, that they are limited in scale and confront a greater range of operating challenges compared to established global players.
Metrioptera brachyptera Linnaeus 1761
Creators: name: Monnerat, C.
name: Thorens, P.
name: Walter, T.
name: Gonseth, Y.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Metrioptera
Metrioptera brachyptera

description: Metrioptera brachyptera (Linnaeus, 1761) Kurzflüglige Beissschrecke NT
description: Published as part of Monnerat C., Thorens P., Walter T. & Gonseth Y., 2007, Rote Liste der Heuschrecken der Schweiz, pp. 1-62 in Umwelt-Vollzug 7 (19) on page 34, DOI: 10.5281/zenodo.270238