cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chitin oligosaccharide deacetylase from Shewanella baltica ATCC BAA-1091
Creators: name: Hirano, Takako
name: Shiraishi, Haruka
name: Ikejima, Masafumi
name: Uehara, Rie
name: Hakamata, Wataru
name: Nishio, Toshiyuki
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Chitin oligosaccharide deacetylase (COD) from bacteria that have been examined so far typically comprise two carbohydrate-binding domains (CBDs) and one polysaccharide deacetylase domain. In contrast, Shewanella baltica ATCC BAA-1091 COD (Sb-COD) has only one CBD, yet exhibits chitin-binding properties and substrate specificities similar to those of other CODs.
Roman and medieval coins found during sewer renewal in Carlisle, 1983-87.
Creators: name: Caruana, Ian D
name: Shotter, David C A
name: Pine, E J E
name: Pirie, Elizabeth J E
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 65-76
description: Provides details of sites and lists of coins. `Northumbrian stycas' are described by E J E Pirie (74--6).
Signalling and the design of the Cumberland Coast System.
Creators: name: Woolliscroft, David J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 55-64
description: A consideration of the Cumberland coastal defence system's design and signalling following on from similar recent studies of other Roman frontiers. The survey of the signalling system mainly concerns the section between Bowness and Flimby in its known and finished form.
Recent excavations on Hadrian's Wall, Burgh-by-Sands.
Creators: name: Austen, Paul S
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 35-54
description: Presents an account of two excavations and a number of smaller observations of remains of Hadrian's Wall in Burgh-by-Sands undertaken between 1978 and 1989. Results include the discovery that sections of the turf wall were underlain with a cobbled surface.
Rome and the Brigantes: Early Hostilities.
Creators: name: Shotter, David C A
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 21-34
description: The fruits of fieldwork over recent years allow for a refinement of understanding concerning Roman expansion in the north west of Britain. There is an `Appendix: the coins and their sources' (32--4).
A Bronze Age gold neckring from Greysouthen, Cumbria.
Creators: name: Needham, Stuart P
name: Richardson, Colin
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 13-20
description: Reports a fragmentary gold ornament discovered in 1991 and declared Treasure Trove in 1992. There is a report on the fabric `Analysis' using X-ray fluorescence by Duncan Hook (15).
The Stone Circle of Long Meg and Her Daughters, Little Salkeld.
Creators: name: Burl, H Aubrey W
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 1-12
description: A detailed overview of the monument, encompassing possible origins for the name, antiquarian attention over the years, alignments and physical comparison to other like-monuments, and possible models for its use and role in its contemporary community.
Ramucirumab in combination with dacarbazine in patients with progressive well-differentiated metastatic pancreatic neuroendocrine tumors (RamuNET): study protocol for a multicenter single-arm trial
Creators: name: Krug, Sebastian
name: Kegel, Thomas
name: Gress, Thomas M.
name: Rinke, Anja
name: Apostolidis, Leonidas
name: Jann, Henning
name: König, Alexander
name: Hörsch, Dieter
name: Schrader, Jörg
name: Ettrich, Thomas J.
name: Richter, Michael
name: Steighardt, Jörg
name: Michl, Patrick
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: PanNET
subject: PNET
subject: Chemotherapy
subject: Ramucirumab
subject: DTIC
subject: Neuroendocrine
subject: PROGNOSTIC-FACTORS
subject: DOUBLE-BLIND
subject: 1ST-LINE THERAPY
subject: BEVACIZUMAB
subject: PLACEBO
subject: ANGIOGENESIS
subject: TEMOZOLOMIDE
subject: RESISTANCE
subject: STREPTOZOCIN
subject: DDC 610 / Medicine & health

description: Abstract Background Cytotoxic chemotherapy combinations and targeted agents represent established treatment concepts in advanced pancreatic neuroendocrine tumors (PNETs). However, response rates, side effects and outcome data strongly vary among these therapeutic approaches. Head-to-head comparisons between chemo- and molecular therapies are missing and secondary resistances frequently occur. The RamuNET trial aims to identify the effectiveness of dual treatment with DTIC and ramucirumab in progressive advanced PNET patients. Methods The RamuNET study is an investigator-initiated multicenter prospective single-arm trial to evaluate the efficacy of ramucirumab in combination with dacarbazine (DTIC) over a period of at least 6 months. Patients with progressive well-differentiated and metastatic pancreatic neuroendocrine tumors are eligible. The study aims to include 45 patients over a period of 24 months with a minimum follow-up of 24 months. The primary endpoint is disease control after 6 months. Secondary endpoints include progression-free survival, biochemical response, overall survival, quality of life and toxicity. Based on the hypothesis that 80% of the patients can achieve a disease control after 6 months, the sample size calculation follows an exact binomial single-stage design. H0: p < =p0 = 60% versus H1: p > =p1 = 80%, alpha = 0.05, beta = 0.1. Discussion This study investigates a new therapeutic approach using the combination of cytotoxic and targeted antiangiogenic therapy in advanced PNET. If positive, this trial will be the basis for a randomized two-arm study to investigate the combination of ramucirumab and DTIC against other established therapies in PNET. Trial registration EudraCT: 2017–001207-68. Date of registration: 2018.01.03.
Additional file 2 of Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort
Creators: name: Azzouz, Mehjar
name: Xu, Yiyi
name: Barregard, Lars
name: Fagerberg, Björn
name: Zöller, Bengt
name: Molnár, Peter
name: Oudin, Anna
name: Spanne, Mårten
name: Engström, Gunnar
name: Stockfelt, Leo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Additional file 2.
Variation and change in the use of hestitation markers in Germanic languages
Creators: name: Wieling, Martijn
name: Grieve, Jack
name: Bouma, Gosse
name: Fruehwald, Josef
name: Coleman, John
name: Liberman, Mark
Publisher: name: Brill Online
Year: 2016
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: Data, methods and results
In this study, we investigate crosslinguistic patterns in the alternation between UM, a hesitation marker consisting of a neutral vowel followed by a final labial nasal, and UH, a hesitation marker consisting of a neutral vowel in an open syllable. Based on a quantitative analysis of a range of spoken and written corpora, we identify clear and consistent patterns of change in the use of these forms in various Germanic languages (English, Dutch, German, Norwegian, Danish, Faroese) and dialects (American English, British English), with the use of UM increasing over time relative to the use of UH. We also find that this pattern of change is generally led by women and more educated speakers. Finally, we propose a series of possible explanations for this surprising change in hesitation marker usage that is currently taking place across Germanic languages.
Additional file 3 of Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort
Creators: name: Azzouz, Mehjar
name: Xu, Yiyi
name: Barregard, Lars
name: Fagerberg, Björn
name: Zöller, Bengt
name: Molnár, Peter
name: Oudin, Anna
name: Spanne, Mårten
name: Engström, Gunnar
name: Stockfelt, Leo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Additional file 3.
The Babylonian Dodecatemoria and Calendar Texts: Inverse Schemes for Determining Position and Times for the Schematic Sun and Moon
Creators: name: Brack-Bernsen, Lis
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Babylonian Mathematical Astronomy, Lunar and Solar Theory, Dodecatemoria, Calendar Texts
subject: 510 Mathematik
subject: 520 Astronomie
subject: 900 Geschichte

description: The Dodecatemoria may be understood as a very simple reproduction of the Moon’s movement: for each day in the schematic year, the Dodecatemoria-scheme gives the position of the schematic Moon in the zodiacal circle. The Moon’s angular velocity was calculated as 13°/day and the Sun’s, as 1°/day. The scheme of the Calendar Texts may also be interpreted astronomically: for each position in the zodiacal circle, it gives the date at which the schematic Moon was in that position. We know that the schemes are inverse. A closer analysis of the texts accompanying the Calendar Text (LBAT 1586+1587) shows that the Babylonians also knew and utilized that fact as well.
In Memoriam: James Mcintyre, F.S.A.; William Edward Simpson Patrickson; Major James Winstanley Cropper; Canon Samuel Taylor, M.A.; Mr Charles William Robinson
Creators: name: Anon,
Publisher: name: Archaeology Data Service
Year: 2017

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 56, 178-180
Accelerated aging in mice with astrocytic redox imbalance as a consequence of SOD2 deletion
Creators: name: Tsesmelis, Konstantinos
name: Maity‐Kumar, Gandhari
name: Croner, Dana
name: Sprissler, Jasmin
name: Tsesmelis, Miltiadis
name: Hein, Tabea
name: Baumann, Bernd
name: Wirth, Thomas
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: CNS
subject: Motoric impairment
subject: Premature aging
subject: SOD2
subject: Manganese superoxide-dismutase
subject: Mitochondrial
subject: Lacking
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Aging
subject: Astrocytes
subject: Brain
subject: Central nervous system
subject: Oxidative stress
subject: Energy metabolism
subject: Altern
subject: Astrozyt
subject: Gehirn
subject: Zentralnervensystem
subject: Oxidativer Stress

description: Aging of the central nervous system (CNS) leads to motoric and cognitive decline and increases the probability for neurodegenerative disease development. Astrocytes fulfill central homeostatic functions in the CNS including regulation of immune responses and metabolic support of neurons and oligodendrocytes. In this study, we investigated the effect of redox imbalance in astrocytes by using a conditional astrocyte-specific SOD2-deficient mouse model (SOD2ako) and analyzed these animals at different stages of their life. SOD2ako mice did not exhibit any overt phenotype within the first postnatal weeks. However, already as young adults, they displayed progressive motoric impairments. Moreover, as these mice grew older, they exhibited signs of a progeroid phenotype and early death. Histological analysis in moribund SOD2ako mice revealed the presence of age-related brain alterations, neuroinflammation, neuronal damage and myelin impairment in brain and spinal cord. Additionally, transcriptome analysis of primary astrocytes revealed that SOD2 deletion triggered a hypometabolic state and promoted polarization toward A1-neurotoxic status, possibly underlying the neuronal and myelin deficits. Conclusively, our study identifies maintenance of ROS homeostasis in astrocytes as a critical prerequisite for physiological CNS aging.
Additional file 4 of Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort
Creators: name: Azzouz, Mehjar
name: Xu, Yiyi
name: Barregard, Lars
name: Fagerberg, Björn
name: Zöller, Bengt
name: Molnár, Peter
name: Oudin, Anna
name: Spanne, Mårten
name: Engström, Gunnar
name: Stockfelt, Leo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Additional file 4.
Trueness of full-arch IO scans estimated based on 3D translational and rotational deviations of single teeth : an in vitro study
Creators: name: Radeke, Johanna
name: Vogel, Annika B.
name: Schmidt, Falko
name: Kilic, Fatih
name: Repky, Stefan
name: Beyersmann, Jan
name: Lapatik, Bernd G.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Intraoral scanning
subject: Digital impression
subject: Full arch scan
subject: Trueness
subject: DDC 510 / Mathematics
subject: DDC 610 / Medicine & health
subject: Photography, Dental
subject: Digitales Drucksystem

description: Objectives To three-dimensionally evaluate deviations of full-arch intraoral (IO) scans from reference desktop scans in terms of translations and rotations of individual teeth and different types of (mal)occlusion. Materials and methods Three resin model pairs reflecting different tooth (mal)positions were mounted in the phantom head of a dental simulation unit and scanned by three dentists and three non-graduate investigators using a confocal laser IO scanner (Trios 3®). The tooth-crown surfaces of the IO scans and reference scans were superimposed by means of best-fit alignment. A novel method comprising the measurement of individual tooth positions was used to determine the deviations of each tooth in the six degrees of freedom, i.e., in terms of 3D translation and rotation. Deviations between IO and reference scans, among tooth-(mal)position models, and between dentists and non-graduate investigators were analyzed using linear mixed-effects models. Results The overall translational deviations of individual teeth on the IO scans were 76, 32, and 58 µm in the lingual, mesial, and intrusive directions, respectively, resulting in a total displacement of 114 µm. Corresponding rotational deviations were 0.58° buccal tipping, 0.04° mesial tipping, and 0.14° distorotation leading to a combined rotation of 0.78°. These deviations were the smallest for the dental arches with anterior crowding, followed by those with spacing and those with good alignment (p < 0.05). Results were independent of the operator’s level of education. Conclusions Compared to reference desktop scans, individual teeth on full-arch IO scans showed high trueness with total translational and rotational deviations < 115 µm and < 0.80°, respectively. Clinical relevance Available confocal laser IO scanners appear sufficiently accurate for diagnostic and therapeutic orthodontic applications. Results indicate that full-arch IO scanning can be delegated to non-graduate dental staff members.
Additional file 5 of Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort
Creators: name: Azzouz, Mehjar
name: Xu, Yiyi
name: Barregard, Lars
name: Fagerberg, Björn
name: Zöller, Bengt
name: Molnár, Peter
name: Oudin, Anna
name: Spanne, Mårten
name: Engström, Gunnar
name: Stockfelt, Leo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Additional file 5.
Additional file 6 of Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort
Creators: name: Azzouz, Mehjar
name: Xu, Yiyi
name: Barregard, Lars
name: Fagerberg, Björn
name: Zöller, Bengt
name: Molnár, Peter
name: Oudin, Anna
name: Spanne, Mårten
name: Engström, Gunnar
name: Stockfelt, Leo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Additional file 6.
Supplementary Material for: Effect of Type I Diabetes on the Proteome of Mouse Oocytes
Creators: name: Jiang, G.
name: Zhang, G.
name: An, T.
name: He, Z.
name: Kang, L.
name: Yang, X.
name: Gu, Y.
name: Zhang, D.
name: Wang, Y.
name: Gao, S.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: Type I diabetes is a global public health concern that affects young people of reproductive age and can damage oocytes, reducing their maturation rate and blocking embryonic development. Understanding the effects of type I diabetes on oocytes is important to facilitate the maintenance of reproductive capacity in female diabetic patients. Methods: To analyze the effects of type I diabetes on mammalian oocytes, protein profile changes in mice with streptozotocin-induced type I diabetes were investigated using proteomic tools; non-diabetic mouse oocytes were used as controls. Immunofluorescence analysis for the spindle and mitochondria of oocytes. Results: We found that type I diabetes severely disturbed the metabolic processes of mouse oocytes. We also observed significant changes in levels of histone H1, H2A/B, and H3 variants in diabetic oocytes (fold change: > 0.4 or < -0.4), with the potential to block activation of the zygotic genome and affect early embryo development. Furthermore, diabetic oocytes exhibited higher abnormal spindle formation and spatial remodeling of mitochondria than observed in the controls. Conclusion: Our results indicate that type I diabetes disrupts metabolic processes, spindle formation, mitochondria distribution and modulates epigenetic code in oocytes. Such effects could have a major impact on the reproductive dynamics of female patients with type I diabetes.
Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results
Creators: name: Rücker, Frank G.
name: Du, Ling
name: Luck, Tamara J.
name: Benner, Axel
name: Krzykalla, Julia
name: Gathmann, Insa
name: Voso, Maria Teresa
name: Amadori, Sergio
name: Prior, Thomas W.
name: Brandwein, Joseph M.
name: Appelbaum, Frederick R.
name: Medeiros, Bruno C.
name: Tallman, Martin S.
name: Savoie, Lynn
name: Sierra, Jorge
name: Pallaud, Celine
name: Sanz, Miguel A.
name: Jansen, Joop H.
name: Niederwieser, Dietger
name: Fischer, Thomas
name: Ehninger, Gerhard
name: Heuser, Michael
name: Ganser, Arnold
name: Bullinger, Lars
name: Larson, Richard A.
name: Bloomfield, Clara D.
name: Stone, Richard M.
name: Döhner, Hartmut
name: Thiede, Christian
name: Döhner, Konstanze
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Prognosis
subject: Translational research
subject: INTERNAL TANDEM DUPLICATIONS
subject: HUMAN BONE-MARROW
subject: YOUNGER ADULTS
subject: MUTATIONS
subject: CELLS
subject: AML
subject: PROLIFERATION
subject: CHEMOTHERAPY
subject: RESISTANCE
subject: DIAGNOSIS
subject: DDC 610 / Medicine & health

description: Abstract In acute myeloid leukemia (AML) internal tandem duplications of the FLT3 gene (FLT3-ITD) are associated with poor prognosis. Retrospectively, we investigated the prognostic and predictive impact of FLT3-ITD insertion site (IS) in 452 patients randomized within the RATIFY trial, which evaluated midostaurin additionally to intensive chemotherapy. Next-generation sequencing identified 908 ITDs, with 643 IS in the juxtamembrane domain (JMD) and 265 IS in the tyrosine kinase domain-1 (TKD1). According to IS, patients were categorized as JMDsole (n = 251, 55%), JMD and TKD1 (JMD/TKD1; n = 117, 26%), and TKD1sole (n = 84, 19%). While clinical variables did not differ among the 3 groups, NPM1 mutation was correlated with JMDsole (P = 0.028). Overall survival (OS) differed significantly, with estimated 4-year OS probabilities of 0.44, 0.50, and 0.30 for JMDsole, JMD/TKD1, and TKD1sole, respectively (P = 0.032). Multivariate (cause-specific) Cox models for OS and cumulative incidence of relapse using allogeneic hematopoietic cell transplantation (HCT) in first complete remission as a time-dependent variable identified TKD1sole as unfavorable and HCT as favorable factors. In addition, Midostaurin exerted a significant benefit only for JMDsole. Our results confirm the distinct molecular heterogeneity of FLT3-ITD and the negative prognostic impact of TKD1 IS in AML that was not overcome by midostaurin.
Additional file 7 of Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort
Creators: name: Azzouz, Mehjar
name: Xu, Yiyi
name: Barregard, Lars
name: Fagerberg, Björn
name: Zöller, Bengt
name: Molnár, Peter
name: Oudin, Anna
name: Spanne, Mårten
name: Engström, Gunnar
name: Stockfelt, Leo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Additional file 7.
Mixed emotional variants of gratitude: antecedent situations, cognitive appraisals, action tendencies, and psychosocial outcomes
Creators: name: Oh, Vincent Y. S.
name: Tong, Eddie M. W.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: This research provides an exploratory investigation of whether gift/help-receiving contexts that elicit mixed emotional variants of gratitude can be distinguished from typical gratitude-eliciting situations in their associated appraisals, action tendencies, and psychosocial effects. We examined 473 participants (159 males, 312 females, 2 others; Mage = 31.07) using a one-way four-conditions between-subjects experiment. Participants were randomly assigned to complete recall tasks describing four different gratitude-eliciting situations. Emotions, cognitive appraisals, action tendencies, and general psychosocial outcomes were assessed. Relative to a control condition involving receiving a gift or help (gift/help condition), receiving something at the expense of a benefactor (benefactor-inconvenience condition) elicited gratitude-guilt; receiving something with an expectation of return (return-favour condition) elicited gratitude-disappointment and gratitude-anger; while receiving a disliked gift or receiving assistance that made things worse (backfire condition) primarily elicited gratitude-disappointment while also eliciting gratitude-anger and gratitude-guilt. Each condition was differentiable from control in their appraisals, action tendencies, and psychosocial effects. Notably, contexts which elicited mixed emotional variants of gratitude were characterised by the co-occurrence of conflicting appraisals such as pleasantness and unpleasantness or goal-congruence and goal-incongruence. Additionally, the return-favour and backfire conditions were most dissimilar from control, and were associated with the most negative action tendencies and psychosocial outcomes.
A photopatternable conjugated polymer with thermal‐annealing‐promoted interchain stacking for highly stable anti‐counterfeiting materials
Creators: name: Liu, Chengwei
name: Steppert, Ann‐Kathrin
name: Liu, Yazhi
name: Weis, Philipp
name: Hu, Jianyu
name: Nie, Chen
name: Xu, Wen‐Cong
name: Kühne, Alexander J. C.
name: Wu, Si
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: annealing
subject: anti‐counterfeiting
subject: photoresponsive
subject: stable
subject: DDC 540 / Chemistry & allied sciences
subject: Conjugated polymers
subject: Thermoresponsive polymers
subject: Konjugierte Polymere

description: Photoresponsive polymers can be conveniently used to fabricate anti‐counterfeiting materials through photopatterning. However, an unsolved problem is that ambient light and heat can damage anti‐counterfeiting patterns on photoresponsive polymers. Herein, photo‐ and thermostable anti‐counterfeiting materials are developed by photopatterning and thermal annealing of a photoresponsive conjugated polymer (MC‐Azo). MC‐Azo contains alternating azobenzene and fluorene units in the polymer backbone. To prepare an anti‐counterfeiting material, an MC‐Azo film is irradiated with polarized blue light through a photomask, and then thermally annealed under the pressure of a photonic stamp. This strategy generates a highly secure anti‐counterfeiting material with dual patterns, which is stable to sunlight and heat over 200 °C. A key for the stability is that thermal annealing promotes interchain stacking, which converts photoresponsive MC‐Azo to a photostable material. Another key for the stability is that the conjugated structure endows MC‐Azo with desirable thermal properties. This study shows that the design of photopatternable conjugated polymers with thermal‐annealing‐promoted interchain stacking provides a new strategy for the development of highly stable and secure anti‐counterfeiting materials.
Influence of the pesticide flupyradifurone on mobility and physical condition of larval green lacewings
Creators: name: Scheibli, Leonie
name: Elsenhans, Tabita
name: Wolf, Harald
name: Stemme, Torben
name: Pfeffer, Sarah Elisabeth
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Agroecology
subject: Behavioural ecology
subject: Entomology
subject: Neurophysiology
subject: DDC 570 / Life sciences

description: Global pesticide use in agriculture is one reason for the rapid insect decline in recent years. The relatively new pesticide flupyradifurone is neurotoxic to pest insects but considered harmless to bees according to previous risk assessments. With this study, we aim to investigate lethal and sublethal effects of flupyradifurone on larvae of the beneficial arthropod Chrysoperla carnea. We treated the animals orally with field-realistic concentrations of flupyradifurone and examined lethality as well as effects on condition, mobility and locomotion. For the lethal dose 50, we determined a value of > 120–200 ng/mg (corresponding to a mean amount of 219 ng/larva) after 168 h. Abnormal behaviors such as trembling and comatose larvae were observed even at the lowest concentration applied (> 0–20 ng/mg, 59 ng/larva). Mobility analysis showed impaired activity patterns, resulting in acute hypoactivity at all pesticide concentrations and time-delayed hyperactivity in larvae treated with > 40–60 ng/mg (100 ng/larva) and > 80–100 ng/mg (120 ng/larva), respectively. Even locomotion as a fundamental behavioral task was negatively influenced throughout larval development. In conclusion, our results demonstrate that flupyradifurone impacts life and survival of lacewing larvae and may pose—despite its status as bee-friendly—a major threat to insect fauna and environment.
Party, policy – or both? Partisan-biased processing of policy arguments in direct democracy
Creators: name: Colombo, Céline
name: Kriesi, Hanspeter
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: How do party cues and policy information affect citizens’ political opinions? In direct democratic settings, this question is particularly relevant. Direct democratic campaigns are information-rich events which offer citizens the opportunity to learn detailed information about a policy. At the same time parties try to influence citizens’ decision procedure by publishing their own positions on the issue. The current debate on whether “party” or “policy” has more impact on political opinions has not yet yielded conclusive results. We examine the effect of policy arguments and party cues on vote intention in two Swiss referendum votes using panel survey data. To the simple dichotomous question of “party cues or policy information” we add an additional twist in asking how party cues affect the processing of policy information through processes of motivated reasoning. We find first that both, policy arguments and party cues, have an independent effect on vote intention. However, in a second part of the analysis, we find strong evidence for partisan-biased processing of policy arguments – that is, voters tend to align their arguments with their preferred party’s position. Our conclusions with regard to the democratic quality of these vote decisions are therefore ambivalent.
title: OFROM: interview avec unine15a82m
Creators: name: Delafontaine, François
name: Ehinger, Maude
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.ca99ul2c.v2#7396755d573ebdf91b617d1a184bf73a97d048ef
The divide between daily event appraisal and emotion experience in major depression
Creators: name: Panaite, Vanessa
name: Cohen, Nathan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Appraisal theories predict that emotional experiences are tightly linked to context appraisals. However, depressed people tend to perceive a variety of emotional events more negatively and stressfully and their emotional experience has been described as context insensitive. This raises the question: how different is the intensity of context appraisals from related emotion experiences among depressed relative to healthy people? Surprisingly, we do not know how cohesive intensity of context appraisals and emotional experiences are in depression. In this study, we assessed differences in intensity of context appraisals and emotional experiences across 1634 daily events during three days within and between depressed participants (N = 41) and healthy controls (N = 33) using linear mixed models. Models compared intensities of stressfulness and unpleasantness appraisals to the intensity of negative affect, and intensity of pleasantness appraisals to the intensity of positive affect. Our findings partially supported our predictions of lower cohesiveness in depression: while intensities of pleasantness appraisals and positive affect were more alike among control participants, intensities of unpleasantness and stressfulness appraisals were more similar to the intensities of negative affect in the depressed group. Current work suggests that hedonic dysfunction in depression is possibly driven by a loosely tied positive context appraisal-emotion experience process.
Analysis of the GPR17 receptor in NG2‐glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions
Creators: name: Miralles, Antonio J.
name: Unger, Nicole
name: Kannaiyan, Nirmal
name: Rossner, Moritz J.
name: Dimou, Leda
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: OPC
subject: Behavior
subject: Mouse
subject: Proliferation
subject: DDC 610 / Medicine & health
subject: Neuroglia
subject: Cell Differentiation
subject: Models, Animal
subject: Sequence analysis, RNA
subject: Oligodendrocyte precursor cells
subject: Oligodendrocyt
subject: Tiermodell

description: NG2-glia comprise a heterogeneous population of cycling cells that give rise to mature, myelinating oligodendrocytes. The mechanisms that regulate the process of differentiation from NG2-glia into oligodendrocytes are still not fully understood but over the last years the G Protein-coupled Receptor 17 (GPR17) has been on the spotlight as a possible key regulator. Interestingly, GPR17-expressing NG2-glia show under physiological conditions a slower and lower level of differentiation compared to NG2-glia without GPR17. In contrast, after a CNS insult these react with proliferation and differentiation in a high rate, pointing towards a role in repair processes. However, the role of GPR17+ NG2-glia under healthy conditions in adulthood has not been addressed yet. Therefore, we aimed here to characterize the GPR17-expressing NG2-glia. Using transgenic mouse models, we showed restricted GPR17 expression in only some NG2-glia. Furthermore, we found that these cells constitute a distinct subset within the NG2-glia population, which shows a different gene expression profile and behavior when compared to the total NG2-glia population. Genetic depletion of GPR17+ cells showed that these are not contributing to the dynamic and continuous generation of new oligodendrocytes in the adult brain. Taken together, GPR17+ NG2-glia seem to play a distinct role under physiological conditions that goes beyond their classic differentiation control, that needs to be further elucidated. These results open new avenues for using the GPR17 receptor as a target to change oligodendrogenesis under physiological and pathological conditions, highlighting the importance of further characterization of this protein for future pharmacological studies.
Longitudinal integrated clerkships*
Creators: name: Hudson, Judith Nicky
name: Poncelet, Ann N.
name: Weston, Kath M.
name: Bushnell, John A.
name: Farmer, Elizabeth A
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: There is increased interest in longitudinal integrated clerkships (LICs) due to mounting evidence of positive outcomes for students, patients and supervising clinicians. Emphasizing continuity as the organizing principle of an LIC, this article reviews evidence and presents perspectives of LIC participants concerning continuity of care, supervision and curriculum, and continuity with peers and systems of care. It also offers advice on implementing or evaluating existing LIC programs.
A phase II study of the PI3K inhibitor copanlisib in combination with the anti-CD20 monoclonal antibody rituximab for patients with marginal zone lymphoma: treatment rationale and protocol design of the COUP-1 trial
Creators: name: Grunenberg, Alexander
name: Kaiser, Lisa M.
name: Woelfle, Stephanie
name: Schmelzle, Birgit
name: Viardot, Andreas
name: Möller, Peter
name: Barth, Thomas F. E.
name: Muche, Rainer
name: Dreyhaupt, Jens
name: Raderer, Markus
name: Kiesewetter, Barbara
name: Buske, Christian
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Marginal zone lymphoma
subject: PI3K inhibitor
subject: Copanlisib
subject: Rituximab
subject: BAY 80-6946
subject: IDELALISIB
subject: THERAPY
subject: P110-ALPHA
subject: MECHANISM
subject: DDC 610 / Medicine & health

description: Abstract Background Advanced stage marginal zone lymphoma (MZL) is an incurable indolent B-cell lymphoma, for which a wide variety of treatments ranging from single agent rituximab to more dose intense immunochemotherapy exists. One of the major goals in this palliative setting is to develop chemotherapy-free treatments, which approach the efficacy of immunochemotherapies, but avoid chemotherapy associated toxicity in this often elderly patient population. The PI3K inhibitor copanlisib has recently shown remarkable clinical activity in refractory or relapsed indolent B–cell lymphomas, among them MZL. Based on these data, copanlisib monotherapy was granted breakthrough designation by the FDA for the treatment of adult patients with relapsed marginal zone lymphoma who have received at least two prior therapies. However, data are still limited in particular for MZL. Based on this, the COUP-1 trial aims at testing the toxicity and efficacy of copanlisib in combination with rituximab in treatment naive and relapsed MZL. Methods COUP-1 is a prospective, multicenter, single-arm, open-label, non-randomized phase II trial of 6 cycles (28 days cycle) of copanlisib (60 mg intravenous day 1, 8, 15) and rituximab (375 mg/m2 intravenous day 1) in the induction phase followed by a maintenance phase of copanlisib (d1, d15 every 4 weeks for a maximum of 12 cycles) and rituximab (d1 every 8 weeks for a maximum of 12 cycles) in patients aged ≥18 years with previously untreated or relapsed MZL in need of treatment. A total of 56 patients are to be enrolled. Primary endpoint is the complete response (CR) rate determined 12 months after start of induction therapy. Secondary endpoints include the overall response (OR) rate, progression free survival (PFS), overall survival (OS), safety and patient related outcome with quality of life. The study includes a translational bio-sampling program with the prospect to measure minimal residual disease. The study was initiated in November 2019. Discussion The COUP-1 trial evaluates the efficacy and toxicity of the treatment of copanlisib in combination with rituximab in patients with MZL and additionally offers the chance for translational research in this heterogenous type of lymphoma. Trial registration ClinicalTrials.gov: NCT03474744. Registration date: 03/23/2018.
Additional file 1 of Multimorbidity among midlife women in India: well-being beyond reproductive age
Creators: name: Puri, Parul
name: Sinha, Abhinav
name: Mahapatra, Pranab
name: Pati, Sanghamitra
Publisher: name: figshare
Year: 2022
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1. Multivariable analysis of chronic disease score among women in mid-life years (45–65 years).
Symbolic number ordering strategies and math anxiety
Creators: name: Dubinkina, Natalia
name: Sella, Francesco
name: Vanbecelaere, Stefanie
name: Reynvoet, Bert
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Math anxiety results in a drop in performance on various math-related tasks, including the symbolic number ordering task in which participants decide whether a triplet of digits is presented in order (e.g. 3-5-7) or not (e.g. 3-7-5). We investigated whether the strategy repertoire and reaction times during a symbolic ordering task were affected by math anxiety. In study 1, participants performed an untimed symbolic number ordering task and indicated the strategy they used on a trial-by-trial basis. The use of the memory retrieval strategy, based on the immediate recognition of the triplet, decreased with high math anxiety, but disappeared when controlling for general anxiety. In the study 2, participants completed a timed version of the number order task. High math-anxious participants used the decomposition strategy (e.g. 5 is larger than 3 and 7 is larger than 5 to decide whether 3-5-7 is in the correct order) more often, and were slower in responding when both memory- and other decomposition strategies were used. Altogether, both studies demonstrate that high-math anxious participants are not only slower to decide whether a number triplet is in the correct order, but also rely more on procedural strategies.
The buildings of Moorhouse, Burgh by Sands.
Creators: name: Jennings, Nina
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 93, 237-268
description: Presents a survey, based on cartographic, documentary, and building survey evidence, of the vernacular architecture at Moorhouse. Farm buildings, houses, wash-houses and coach-houses figure, along with the Friend's Meeting House. Details of particular note include the similarity between farmhouse plans and the extent of clay wall patching. The clay buildings are thought to be of considerable historic interest.
Researcher Skills Development Needs Survey 2023 survey instrument
Creators: name: Steel, Kay
name: Claridge, Cheryl
name: Foster, Jason
name: Roga, Erin
name: McDonald, Kelsey
Publisher: name: Federation University Australia
Year: 2024
Subjects: classificationCode: 390305
subject: Professional education and training
classificationCode: 460912
subject: Knowledge and information management

description: Federation University Australia Library conducted a survey of researchers, including Higher Degree by Research candidates, at the University during mid-2023 to obtain data on researcher requirements related to digital skills development. This Collection draws together the Survey instrument, the Report, two Infographics presenting some of the responses to the survey as well as a comparison with some of the responses from the 2020 survey, and the de-identified Excel dataset of survey responses.
Bifunctional co‐based catalysts for fischer‐tropsch synthesis : descriptors affecting the product distribution
Creators: name: Straß‐Eifert, Angela
name: Van Der Wal, Lars I.
name: Hernández Mejía, Carlos
name: Weber, Lennart J.
name: Yoshida, Hideto
name: Zečević, Jovana
name: De Jong, Krijn P.
name: Güttel, Robert
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Bifunctional catalyst
subject: Fischer Tropsch synthesis
subject: Supported catalysts
subject: DDC 540 / Chemistry & allied sciences
subject: Cobalt
subject: Heterogeneous catalysis
subject: Bifunktioneller Katalysator

description: Fischer-Tropsch synthesis: The properties of Co/zeolite bifunctional catalysts were correlated to the product distribution in Fischer-Tropsch synthesis. It is observed that both the acidity and the pore structure play a vital role in primary and secondary hydrocracking/isomerization reactions. The conversion of synthesis gas to hydrocarbons in the Fischer‐Tropsch (FT) synthesis suffers from a broad product distribution not directly providing high fuel quality. This work, therefore, aims at bifunctional catalysts combining the FT and hydroprocessing (HP) reaction for tailoring the product spectrum. Therefore, we applied a bottom‐up synthesis strategy for bifunctional cobalt/zeolite catalysts and investigated the obtained materials by advanced characterizations such as 3D TEM tomography. Based on the results, descriptors are defined for the acidity and the porosity, which are varied by changing the material preparation parameters. The catalytic properties of the obtained materials are studied in FT experiments at industrially relevant conditions (20 bar, 240 and 260 °C) and are correlated to the material properties by means of the respective descriptors. Therefore, the product distribution was analyzed in detail and distinguished between n‐paraffins and 1‐olefins as typical FT‐products as well as paraffinic and olefinic isomers formed in the HP classified in different fractions. It was found that, apart from the acidity, the pore structure plays a vital role in primary and secondary cracking/isomerization reactions. In addition to that, the particular 3D pore structure and thus the individual transport trajectories of the FT products are strongly affecting the cracking and isomerization probability and consequently the product distribution.
Words matter when inferring emotions: a conceptual replication and extension
Creators: name: Ventura-Bort, C.
name: Panza, D.
name: Weymar, M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: It is long known that facial configurations play a critical role when inferring mental and emotional states from others. Nevertheless, there is still a scientific debate on how we infer emotions from facial configurations. The theory of constructed emotion (TCE) suggests that we may infer different emotions from the same facial configuration, depending on the context (e.g. provided by visual and lexical cues) in which they are perceived. For instance, a recent study found that participants were more accurate in inferring mental and emotional states across three different datasets (i.e. RMET, static and dynamic emojis) when words were provided (i.e. forced-choice task), compared to when they were not (i.e. free-labelling task), suggesting that words serve as contexts that modulate the inference from facial configurations. The goal of the current within-subject study was to replicate and extend these findings by adding a fourth dataset (KDEF-dyn), consisting of morphed human faces (to increase the ecological validity). Replicating previous findings, we observed that words increased accuracy across the three (previously used) datasets, an effect that was also observed for the facial morphed stimuli. Our findings are in line with the TCE, providing support for the importance of contextual verbal cues in emotion perception.