cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Perceptions of Entrepreneurship Among Graduate Students: Challenges, Opportunities, and Cultural Biases
Creators: name: Petrescu, Manuela Andreea
name: Suciu, Dan Mircea
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: K.3.2; J.4

description: The purpose of the paper is to examine the perceptions of entrepreneurship of graduate students enrolled in a digital-oriented entrepreneurship course, focusing on the challenges and opportunities related to starting a business. In today's digital era, businesses heavily depend on tailored software solutions to facilitate their operational processes, foster expansion, and enhance their competitive edge, thus assuming, to a certain degree, the characteristics of software companies. For data gathering, we used online exploratory surveys. The findings indicated that although entrepreneurship was considered an attractive option by students, very few of them declared that they intended to start a business soon. The main issues raised by the students were internal traits and external obstacles, such as lack of resources and support. Gender discrimination and cultural biases persist, limiting opportunities and equality for women. In terms of gender, women face limited representation in leadership roles, are expected to do more unpaid 'family work', are perceived as less capable in ding business, and need to prove their skills. Even if women are less discriminated now, both genders agree that women still face discrimination in business domain. In terms of percentages, women mentioned gender discrimination in higher percentages. Addressing these issues requires awareness, education, and policy changes to ensure fair treatment and opportunities for women.
description: In Proceedings of the 16th International Conference on Computer Supported Education - Volume 1, ISBN 978-989-758-697-2, ISSN 2184-5026, pages 347-354
title: The Effects of Chronic Unpredictable Stress on the Ability to Extinguish Fear: Zinc as a Mediator
Creators: name: Knaack, Gretchen Linnea
Publisher: name: George Mason University
Year: 2012
Subjects: subject: Fear Extinction
subject: Zinc
subject: Chronic Unpredictable Stress
subject: PTSD

description: Chronic stress can be deleterious to the brain and it is the unpredictability of these stressors that fails to permit habituation, the effects of which are exhibited through maladaptive behaviors such as Post Traumatic Stress Disorder (PTSD). Implementing a chronic unpredictable stress (CUS) paradigm as an animal model of PTSD may facilitate the examination of possible mechanisms relating prolonged stress to the cognitive deficits frequently observed. One factor may be zinc because it is decreased in the blood while increased in the brain during stress, and it has been previously demonstrated that excess zinc in the brain causes learning and memory deficits. To ascertain this possibility rats were raised pre- and post-natally on supplemented zinc water for four months, administered a 21 day CUS paradigm, and then underwent fear conditioning. Post stress blood samples were also analyzed. Results determined that excess zinc rats displayed learning and memory deficits on the ability to extinguish fear and recall that extinction 24 hours later. CUS decreased the level of zinc in the blood for animals that drank lab water, but increased the amount of zinc in blood for animals that were supplemented with zinc. Furthermore, there was a positive correlation between the level of zinc in the blood and the ability to extinguish fear. These data suggest that zinc may be a mediator between chronic stress and anxiety disorders.
The Perceived Learning Behaviors and Assessment Techniques of First-Year Students in Computer Science: An Empirical Study
Creators: name: Petrescu, Manuela Andreea
name: Mihoc, Tudor Dan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: K.3.2; J.4

description: The objective of our study is to ascertain the present learning behaviors, driving forces, and assessment techniques as perceived by first-year students, and to examine them through the lens of the most recent developments (pandemic, shift to remote instruction, return to in-person instruction). Educators and educational institutions can create a more accommodating learning environment that takes into account the varied needs and preferences of students by recognizing and implementing these findings, which will ultimately improve the quality of education as a whole. Students believe that in-person instruction is the most effective way to learn, with exercise-based learning, group instruction, and pair programming. Our research indicates that, for evaluation methods, there is a preference for practical and written examinations. Our findings also underscore the importance of incorporating real-world scenarios, encouraging interactive learning approaches, and creating engaging educational environments.
description: In Proceedings of the 16th International Conference on Computer Supported Education - Volume 2, CSEDU 2024, ISBN 978-989-758-697-2, ISSN 2184-5026, pages 405-412
Axisymmetric displacement flows in fluid-driven fractures
Creators: name: Tanikella, Sri Savya
name: Dressaire, Emilie
Publisher: name: arXiv
Year: 2024
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Displacement flows are common in hydraulic fracturing, as fracking fluids of different composition are injected sequentially in the fracture. The injection of an immiscible fluid at the center of a liquid-filled fracture results in the growth of the fracture and the outward displacement of the interface between the two liquids. We study the dynamics of the fluid-driven fracture which is controlled by the competition between viscous, elastic, and toughness-related stresses. We use a model experiment to characterize the dynamics of the fracture for a range of mechanical properties of the fractured material and fracturing fluids. We form the liquid-filled pre-fracture in an elastic brittle matrix of gelatin. The displacing liquid is then injected. We record the radius and aperture of the fracture, and the position of the interface between the two liquids. In a typical experiment, the axisymmetric radial viscous flow is accommodated by the elastic deformation and fracturing of the matrix. We model the coupling between elastic deformation, viscous dissipation, and fracture propagation and recover the two fracturing regimes identified for single fluid injection. For the viscous-dominated and toughness-dominated regimes, we derive scaling equations that describe the crack growth due to a displacement flow and show the influence of the pre-existing fracture on the crack dynamics through a finite initial volume and an average viscosity of the fluid in the fracture.
Appendix 6  : Results of the systematic review by outcome criterion.
Creators: name: FISCHER, Matthieu
name: BUI, Emilie
Publisher: name: Zenodo
Year: 2025

description: This section provides a consolidated synthesis of the results gathered from the 25 studies included in the systematic review. To facilitate a clear comparison of findings across the diverse body of research, the results are meticulously organized and presented according to specific outcome criteria.

Each key outcome measure investigated in this review is addressed in a dedicated sub-section (or file), aggregating all pertinent data reported by the individual studies for that particular criterion. This structure is designed to allow readers to efficiently access and compare the evidence pertaining to a single outcome across all included studies.

Given the considerable volume of aggregated data points and detailed summaries, this comprehensive results synthesis is presented in French. Nevertheless, the core quantitative findings and statistical results largely adhere to standard international mathematical and reporting norms, which should facilitate their interpretation by a non-French-speaking audience familiar with scientific data presentation.
title: Competition And The Provision Of Hospital Community Benefits
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: In the first chapter, I investigate whether nonprofit hospitals increase(decrease) with more(less) market power using the 2010-2016 IRS Form 990 Schedule H, American Hospital Association Annual Survey, and Healthcare Cost Report Information (HCRIS) database at the national level. The results show that higher levels of hospital concentration lead to a higher provision of community benefits when total market fixed-effects are controlled for. When hospital fixed-effects are controlled, the association between hospital concentration and community benefits provision becomes negative. This suggests that hospital-specific and market-level characteristics might explain the provision of community benefits better than a hospitals’ market power. In the second chapter, I add insurer market concentration to the analysis by adding Decision Resource Groups (DRG) dataset. Using Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID), I also estimate hospital choice model of patients to calculate hospital competition to address endogeneity issues of traditional competition measure. As a trade-off, I investigate the same hypothesis for only the following states from 2012 to 2016: Florida, New York, Vermont, Massachusetts, Arizona, and Utah. The results show that, considering the insurer competition, nonprofit hospitals do have increased community benefit provisions with more market power; however, there is no statistically significant evidence of the effect of hospital and insurer competition on the community benefit provision of nonprofit hospitals. In the third and final chapter, I argue that the IRS and the hospitals do not observe whether community benefit activities actually promote the communities’ health. I investigate this issue by examining how hospital market power affects the prevention quality indicators of uninsured patients — as an indication of community health. I use the data from IRS Form 990, HCRIS, and HCUP State Inpatient Database for six states from 2012 to 2016. The results show no significant evidence that nonprofit hospitals improve their communities through community benefit provisions in more concentrated markets. Unlike the hospital competition, there are supporting evidence that prevention quality indicators improve in more concentrated insurer markets.
A LOFAR sample of luminous compact radio sources coincident with nearby dwarf galaxies
Creators: name: Vohl, Dany
name: Bhandari, Shivani
name: Marcote, Benito
name: Kirsten, Franz
name: Ould-Boukattine, Omar
Publisher: name: Zenodo
Year: 2023

description: Single slide discussing paper by Vohl et al. 2023 at 9th Annual Science At Low Frequencies (SALF) Conference (2023, Amsterdam, the Netherlands), which presents an updated version of plot by Bhandari et al. 2023, adding a new bound on physical size of ILT J090406.54+530314.6 derived from European VLBI Network observations.
title: Combining Machine Learning with Evolutionary Computation: Recent Results on LEM
Creators: name: Cervone, Guido
name: Michalski, Ryszard S.
name: Kaufman, Kenneth A.
name: Panait, Liviu A.
Publisher: name: George Mason University
Year: 2000

description: The Learnable Evolution Model (LEM), first presented at the Fourth International Workshop on Multistrategy Learning, employs machine learing to guide evolutionary computation. Specifically, LEM integrates two modes of operation: Machine Learning mode, which employs a machine learning algorithm, and Darwinian Evolution mode, which employs a conventional evolutionary algorithm. The central new idea of LEM is that in machine learning mode, new individuals are "genetically engineered" by a repeated process of hypothesis formation and instantiation, rather than created by random operators of mutation and/or recombination, as in Darwinian-type evolutionary algorithms. At each stage of evoluation, hypotheses are induced by a machine learning system from examples of high and low performance individuals. New individuals are created by instantiating the hypotheses in different ways. In recent experiments concerned with complex function optimization problems, LEM has significantly outperformed selected evolutionary computation algorithms, sometimes achieving speed-ups of the evolutionary process by two or more orders of magnitude (in terms of the number of generations). In another recent application involving a problem of optimizing heat exchangers, LEM produced designs equal or superior to best expert designs. The recent results have confirmed earlier findings that LEM is able to significantly speed-up evolutionary processes (in terms of the number of generations) for certain problems. Further research is needed to determine classes of problems for which LEM is most advantagious.
Dynamics of fluid-driven fractures in the viscous-dominated regime
Creators: name: Tanikella, Sri Savya
name: Sigallon, Marie C
name: Dressaire, Emilie
Publisher: name: arXiv
Year: 2024
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: During hydraulic fracturing, the injection of a pressurized fluid in a brittle elastic medium leads to the formation and growth of fluid-filled fractures. A disc-like or penny-shaped fracture grows radially from a point source during the injection of a viscous fluid at a constant flow rate. We report an experimental study on the dynamics of fractures propagating in the viscous regime. We measure the fracture aperture and radius over time for varying mechanical properties of the medium and fluid and different injection parameters. Our experiments show that the fracture continues to expand in an impermeable brittle matrix, even after the injection stops. {In the viscous regime, the fracture radius scales as $t^{4/9}$ during the injection. Post shut-in, the crack continues to propagate at a slower rate, which agrees well with the predictions of the scaling arguments, as the radius scales as $t^{1/9}$. The fracture finally reaches an equilibrium set by the toughness of the material.} The results provide insights into the propagation of hydraulic fractures in rocks.
title: From Macro to Micro: The Biophysical Importance of Nucleic Acids and Their Interactive Partners
Creators: name: Vo, Tam
Publisher: name: Georgia State University
Year: 2019

description: Nucleic acids carry the genetic information that can be passed down through processes that involving the interactions of them with proteins. One of the critical checkpoints of these processes is transcription, where DNA is transcribed to messenger RNA. Transcription factors (TFs) are proteins that regulate the transcription process of genes to messenger RNA. TFs are essential for gene regulation and expression, and too often, these proteins are associated with many diseases, including cancers. Therefore, it is crucial to dissect the fundamental interactions of TF with nucleic acids.
The ETS family of proteins, one of the significant components in gene regulation, are associated with many diseases, including cancers. Members of this family proteins share a unique feature: a conserved DNA binding domain called ETS domain. The ETS domain recognizes DNA sequences specifically at 5?-GGAA/T-3? and flanking sequences are recognized differently among ETS proteins. Also, the co-structures of ETS proteins-DNA reveal nearly superimposable conformation. Although sharing a conserved binding domain, the role of these proteins is not redundant. The biophysical properties, including how these proteins searching for their target gene sites in the presence of nonspecific competitors in the surrounding environment, remains unclear. This project will focus on better understanding the facilitation mechanisms of ETS TF to support pharmacological control.
In another project, we focus on investigating the selectivity of small molecules toward different structures and sequences of nucleic acids of therapeutic interest. Interactions of these small molecules with different DNA, RNA, and quadruplexes are observed by various biophysical methods, including biosensor surface plasmon resonance, fluorescence spectroscopy, and thermal melting. Altogether, this project aims to understand the structure-function relationship of these selective molecules towards drug development and discovery.
title: Investigating PD-1/PD-L1 Checkpoint Inhibition as a Treatment for Platinum-Resistant Ovarian Cancer
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Cancer immunotherapy
subject: Drug resistance
subject: Extracellular vesicles
subject: PD-1/PD-L1
subject: Biology
subject: Cellular biology
subject: Molecular biology

description: Ovarian cancer is the deadliest cancer of the female reproductive system, with the majority of patients experiencing relapse on first-line platinum-based chemotherapies. Therefore, identifying potential targets for additional second-line therapies is critical for treating platinum-resistant ovarian cancer. To that end, the evolution of platinum resistance in a cell-based model of ovarian cancer was monitored via characterization of proteomic changes in cancer-derived extracellular vesicles (EVs) after progressive rounds of cisplatin treatment. The content of cancer-derived EVs was analyzed via mass spectrometry, reverse phase protein array, and Western blotting to identify pathways that could be targeted by second-line therapies. Several therapeutically relevant markers were identified in EVs collected after cisplatin treatment, including PD-L1 and other proteins regulating PD-L1 export. Monoclonal antibody-based therapies (mAbs) targeting PD-1/PD-L1 have been deployed successfully as second-line treatments for a variety of cancers, but their success has yet to be translated to ovarian cancer. Current mAb-based immunotherapies suffer from several pitfalls, including difficulties in managing immune-related adverse events and poor tumor penetration. As an alternative to anti-PD-1/PD-L1 mAb-based immunotherapies, a small interfering peptide for PD-1/PD-L1 was designed based on the interface region of PD-L1. This lead peptide underwent several rounds of in silico optimization and in vitro validation to identify and screen modifications that could improve affinity for PD-1 or stability in serum. Serum stability studies indicated the modifications dramatically improved stability, with peptide abundance still quantifiable via mass spectrometry after 72 hours. The peptide was also shown to block PD-1/PD-L1 complex formation via Amplified Luminescent Proximity Homogeneous Assay screening. The stabilized peptide, MN1.4, was chosen for further efficacy testing in a cell-based model. An ovarian cancer cell line was co-cultured with human peripheral blood mononuclear cells to measure markers of T cell activation via ELISA after MN1.4 treatment. Results showed that MN1.4 had immunosuppressive effects similar to those of full-length PD-L1, suggesting that MN1.4 was an agonist for PD-1 rather than an inhibitor as was initially hypothesized. Therefore, this peptide could have several applications for treating autoimmune disorders, including those that arise as side effects from mAb-based immunotherapies.
Options For New Forms Of Participation In The Eu (Deliverable 8.11)
Creators: name: Levi Faur, David
Publisher: name: Zenodo
Year: 2016

description: The promotion of European Citizenship and participation of citizens in EU decision making are key aims of the European Union. However, while considerable attention has been focused on citizenship in the political sphere, less has been said about the meaning of citizenship in the economic, the social, and the financial spheres. Following the literature on the financialization of the everyday, this study focuses on the meaning of citizenship in the financial sphere. We illustrate the image of an ideal European financial citizen, as reflected in (and shaped by) EU regulation. We compare this image in two EU directives, on credit (2008) and on payment accounts (2014), and highlight the influences which shaped it, with a particular focus on new forms of citizen participation. The paper argues the image of the ideal financial citizen reflected in these directives is that of a confident, empowered and active citizen, ‘making markets work’. At the same time, however, this image is complemented by the image of a vulnerable citizen, both shielded from the market and encouraged to participate in it. Compared to political citizenship, financial citizenship appears to be more demanding, requiring high levels of human capital, time and attention to detail. Citizenship in the financial sphere is more inclusive, based on the will to participate in the market, as opposed to the more exclusive nature of political citizenship.
title: An Empirical Study of an Anonymity Metric for Data Networks
Creators: name: Vasudevan, Abinash
Publisher: name: George Mason University
Year: 2013
Subjects: subject: Anonymous networks
subject: Privacy
subject: Anonymity metric
subject: Anonymity

description: Privacy and data protection are two very important needs in the modern day Internet. One of the attacks to privacy is eavesdropping, i.e., an outsider or an attacker listens to a private conversation and identifies the people involved in the conversation. In order to protect the content which is to be transmitted, encryption methods are used. Even if the data is encrypted, it is possible for the attacker to identify the end user, i.e., the person sending the data and the person to whom the data is sent. An anonymous network is a type of network that prevents traffic analysis and protects the identity of the end users. Some of the popular anonymous networks, namely Anonymizer.com, TOR, etc., are used for identity concealment. These anonymous networks provide real-time, low latency anonymous communications. Because of the low latency implementation, timing constraints are imposed on the low-latency networks. Due to this timing constraint, an attacker will be able to get details from the packet timing information and use it to identify the end users. This makes the timing attack possible in these low-latency anonymous networks. In this thesis, an anonymity metric that can measure the practical effectiveness of low-latency anonymous network is studied. The anonymity metric calculates the timing distortion between the incoming packets and the outgoing packets and uses wavelet-based Multi-Resolution Analysis (MRA) to determine the anonymity of the network. For the purpose of analysis, packet traffic is simulated based on several stochastic traffic models. The simulated traffic contains information about the timing of packets entering and leaving the anonymous network. The most basic traffic model used for this purpose is the Poisson process; we also use the Markov Modulated Poisson Process and the Markovain Arrival Process for further analysis. The end-to-end network delay is characterized with various probability distributions for this study. The results of the analysis show that the measured energy used to compute the anonymity metric is higher for more complex traffic arrival models, which implies that the anonymity level is correspondingly higher. The more complex traffic patterns introduce more randomness in the timing information, resulting in higher measured energy values. Hence, for example, the Poisson process arrival model has the least energy among the traffic models used in this study.
L'utilisation des langues dans l'enseignement secondaire et supérieur : Croyances et pratiques des enseignants
Creators: name: Cortés Velasquéz, Diego
name: Strasser, Margareta
name: Bogensperger, Theresa
name: Hülsmann, Christoph
name: Zini, Daniela
Publisher: name: Universität Hamburg
Year: 2025

description: Ce rapport, qui s’inscrit dans le projet PEP (Promouvoir l'éducation plurilingue), présente les résultats d'une étude exploratoire menée sur un échantillon non statistique et sur une base volontaire. Il prend appui sur une enquête autour des croyances et des pratiques des professeurs de langues de l'enseignement secondaire et du supérieur en matière de plurilinguisme. Menée à travers l'Europe, l'étude visait à :

1. Examiner les perceptions et les pratiques déclarées des enseignants en matière d'éducation plurilingue ;

2. Identifier les défis et les stratégies d'intégration des approches plurilingues dans l'enseignement et l'évaluation ;

3. Fournir des recommandations en matière de formation et de ressources pour soutenir l'éducation plurilingue.
title: Rapid Synthesis of Multi-Model Simulations for Computational Experiments in C2
Creators: name: Neema, Himanshu
name: Nine, H.
name: Hemingway, G.
name: Sztipanovits, J.
name: Karsai, G.
Publisher: name: George Mason University
Year: 2009
Subjects: subject: Heterogeneous simulation
subject: Multi-paradigm modeling
subject: Multi-model simulation
subject: Distributed simulation
subject: Model-based integration
subject: Meta-modeling
subject: Model-based program synthesis
subject: High-level architecture
subject: Command and control
subject: Data interoperability

description: The research was conducted by Institute for Software Integrated Systems at Vanderbilt University, in collaboration with George Mason University, University of California at Berkeley, and University of Arizona.
description: Abstract-Virtual evaluation of complex command and control concepts demands the use of heterogeneous simulation environments. Development challenges include how to integrate multiple simulation platforms with varying semantics and how to integrate simulation models and the complex interactions between them. While existing simulation frameworks may provide many of the required services needed to coordinate among multiple simulation platforms, they lack an overarching integration approach that connects and relates the semantics of heterogeneous domain models and their interactions. This paper outlines some of the challenges encountered in developing a command and control simulation environment and discusses our use of the GME meta-modeling tool-suite to create a model-based integration approach that allows for rapid synthesis of complex HLA-based simulation environments.
Adapting to the Flow: Reinforcement Learning for Dynamic Priority Assignment in TSN
Creators: name: Sertbaş Bülbül, Nurefsan
name: Fischer, Mathias
Publisher: name: Universität Hamburg
Year: 2023

description: Real-time systems employ prioritization schemes to

accommodate different traffic classes with specific quality of

service (QoS) requirements. However, in some scenarios where

numerous high-priority packages are transmitted, lower-priority

packages may fail to meet their deadlines, leading to a significant

decline in scheduling performance. Sending high-priority flows

excessively early does not provide any additional benefits beyond

meeting the deadline. Instead, it is more effective to utilize

this buffer time for lower-priority traffic and ensure on-time

transmission of high-priority traffic. We propose an adaptive

dynamic priority assignment scheme that utilizes reinforcement

learning (RL) to address this issue. This enables adaptation

to changing network conditions and continual improvement in

performance over time. Additionally, we present and discuss two

potential configuration candidates that can be utilized within the

proposed scheme.
title: Effects Of Different Halide Salts On DNA Photocleavage By 9-aminomethylanthracene Dyes
Creators: name: Safiarian, Mohammad Sadegh
Publisher: name: Georgia State University
Year: 2019

description: This dissertation describes the study of anthracene/DNA interactions with the goal of simulating and understanding the conditions of high ionic strength similar to that of cell nucleus that a DNA photosensitizer might encounter (410 mM). The compounds used for studying the photocleavage reactions were bis 9-aminomethylanthracene dye 2 vs. a mono-anthracene 4, two 9-methylaminoanthracene derivatives. We observed that the addition of sodium and potassium chloride salts into photocleavage reactions containing micromolar concentrations of antharcene triggers the conversion of supercoiled, nicked, and linear forms of pUC19 plasmid into a highly degraded band of DNA fragments, representing a dramatic and unexpected increase in levels of anthracene-sensitized DNA photocleavage (KCl > NaCl; pH 7.0 and 22 øC). Experiments using specific ROS scavengers indicate higher levels of ROS production in presence of chloride salt. Further investigation into the mechanism of ROS production suggests more involvement of type I electron transfer in generation of hydroxyl radicals. In contrast to the chloride salts, anthracene-sensitized DNA photocleavage is inhibited (KI ò NaI ò KBr ò NaBr ò KF ò NaF). The results of CD spectroscopy suggest unwinding of DNA in presence of high concentration of potassium(I) salts and UV-visible absorption and fluorescence experiments point to the possibility of a heavy atom effect involving Br? and I? anions. DNA photocleavage and fluorescence probe experiments point to the involvement of photo-oxidized form of anthracene in ROS generation.
title: Choosing trade partners to avoid falling behind
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2019

description: Recent studies find that firms obtain higher prices and higher productivity by exporting to richer and more distant destinations. This study initiates a discussion of the country-level impact of trade partners (export destinations) on economic growth. In an econometric analysis, I find that low- and middle-income countries grow more slowly when they compete against high-income countries in the same markets. In a case study, I examine how Mexico’s disappointing economic growth is partly explained by its concentration of exports to the U.S. market where it faced competition with similar goods from China. These conditions were not faced by higher-growth Malaysia and Turkey.
title: Multi-Faceted Proteomic Characterization of Host Protein Complement of Rift Valley Fever Virus Virions and Identification of Specific Heat Shock Proteins, Including HSP90, as Important Viral Host Factors
Creators: name: Nuss, Jonathan E.
name: Kehn-Hall, Kylene
name: Benedict, Ashwini
name: Costantino, Julie
name: Ward, Michael
name: Peyser, Brian D.
name: Retterer, Cary J.
name: Tressler, Lyal E.
name: Wanner, Laura M.
name: McGovern, Hugh F.
name: Zaidi, Anum
name: Anthony, Scott M.
name: Kota, Krishna P.
name: Bavari, Sina
name: Hakami, Ramin M.
Publisher: name: Public Library of Science
Year: 2014
Subjects: subject: Rift Valley Fever virus
subject: Small interfering RNAs
subject: Virions
subject: Heat shock response
subject: Chaperone proteins
subject: Membrane proteins
subject: Protein interaction networks
subject: Database searching

description: Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV). Infection with RVFV in ruminants can cause near 100% abortion rates and recent outbreaks in naïve human populations have suggested case fatality rates of greater than thirty percent. To elucidate the roles that host proteins play during RVFV infection, proteomic analysis of RVFV virions was conducted using complementary analytical approaches, followed by functional validation studies of select identified host factors. Coupling the more traditional Gel LC/MS/MS approach (SDS PAGE followed by liquid chromatography tandem mass spectrometry) with an alternative technique that preserves protein complexes allowed the protein complement of these viral particles to be thoroughly examined. In addition to viral proteins present within the virions and virion-associated host proteins, multiple macromolecular complexes were identified. Bioinformatic analysis showed that host chaperones were among over-represented protein families associated with virions, and functional experiments using siRNA gene silencing and small molecule inhibitors identified several of these heat shock proteins, including heat shock protein 90 (HSP90), as important viral host factors. Further analysis indicated that HSP inhibition effects occur during the replication/transcription phase of the virus life cycle, leading to significant lowering of viral titers without compromising the functional capacity of released virions. Overall, these studies provide much needed further insight into interactions between RVFV and host cells, increasing our understanding of the infection process and suggesting novel strategies for anti-viral development. In particular, considering that several HSP90 inhibitors have been advancing through clinical trials for cancer treatment, these results also highlight the exciting potential of repurposing HSP90 inhibitors to treat RVF.
title: Untargeted Metabolomic Studies to Assess Immunogenicity of Centrin Gene-Deleted Leishmania major Parasites in a Mouse Model
Creators: name: Oljuskin, Timur
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Leishmania
subject: Metabolomics
subject: MetaboAnalyst
subject: Parasite vaccine
subject: Immunometabolism
subject: Biomarker

description: Leishmaniasis is a neglected tropical disease that causes severe morbidity and is endemic in 98 countries. Attempts to develop a vaccine have been unfruitful, aside from leishmanization (deliberate inoculation with a miniscule number of virulent Leishmania major parasites that cause cutaneous lesions). However, leishmanization is no longer practiced due to safety concerns. A L. major parasite strain attenuated through gene deletion has shown promising results in preclinical studies in providing protection against wildtype infection without itself causing pathogenesis; Vaccination with such live, attenuated Leishmania parasites is therefore termed second-generation leishmanization. Towards assessing the safety and immunogenicity characteristics of this vaccine strain, untargeted metabolomics analysis was conducted on ears and draining lymph nodes of mice infected with the vaccine strain or the wildtype strain. The studies described here will enable understanding of immune mechanisms of protection, discovery of biomarkers or immunogenicity, and to advance the vaccine towards clinical trials.
title: Handwritten notes: "Facilitator Hints", 1983
Creators: name: Warfield, John
Publisher: name: George Mason University
Year: 1983
Subjects: subject: Warfield, John N.
subject: Facilitator
subject: Interpretive Structural Modeling (ISM)

description: Manuscript: handwritten, 2 pgs. 8.5" x 11" (21.6 cm x 29.7 cm)
description: Handwritten notes by Warfield regarding ways to improve facilitation of Interpretive Structural Modeling (ISM) workshops. John N. Warfield Collection 6.33.3
Erstellung Eines Historischen Korpus Mit Mehrebenenannotation
Creators: name: Hübner, Julia
name: Politt, Katja
name: Schutzeichel, Marc
Publisher: name: Zenodo
Year: 2015
Subjects: corpus
annotation
witch interrogation protocol
ENHG
linguistics

description: Im DFG-Projekt "Entwicklung der satzinternen Großschreibung im Deutschen" wird ein Korpus aus frühneuhochdeutschen Hexenverhörprotokollen (Macha et al. 2005) erstellt. Im Projekt wird der Einfluss unterschiedlicher Faktoren auf die Großschreibung untersucht. Hierzu wird eine Mehrebenenannotation der Texte durchgeführt. Für die einzelnen Ebenen sollen jeweils spezialisierte Annotationstools verwendet werden. Beispielsweise erfolgt die tokenbasierte Annotation halbautomatisch in GATE (Cunningham 2011) mit Hilfe von CAB. Schließlich sollen die Annotationen mit ANNIS (Zeldes et al. 2009) durchsucht werden können. Die Texte durchlaufen unterschiedliche Phasen und Dateiformate, bevor die Annotationen am Ende in PAULA-XML (Dipper et al. 2007) zusammengeführt werden. Neben der technischen Umsetzung der Annotationen ist es eine wichtige Aufgabe, die sprachlichen Besonderheiten der Textsorte zu erfassen. Existierende Annotationsrichtlinien, z.B. HiTS (Dipper et al. 2013) für die PoS Annotation, decken nicht alle Aspekte der Textsorte ab und müssen daher angepasst bzw. erweitert werden. Als Beispiele seien hier die Unterscheidung von Nomina Propria und Appellativa genannt, sowie die schwer festzustellenden Satzgrenzen in den Texten, die von zentraler Bedeutung für die Erfassung der satzinternen Großschreibung sind. Das Poster dokumentiert die Verzahnung der im Projekt entwickelten Skripte und verwendeten Tools in den einzelnen Annotationsphasen sowie Lösungen zu den an der Textsorte der Hexenverhörprotokolle exemplarisch deutlich gewordenen Annotationsproblemen und zeigt damit eine Möglichkeit auf, wie eine Mehrebenenannotation von historischen Texten generell konzipiert und durchgeführt werden kann.
description: {"references": ["Cunningham, Hamish, Diana Maynard & Kalina Bontcheva. 2011. Text processing with GATE (Version 6). University of Sheffield, Department of Computer Science.", "Dipper, Stefanie, Karin Donhauser, Thomas Klein, Sonja Linde, Stefan M\u00fcller & Klaus-Peter Wegera. 2013. HiTS: ein Tagset f\u00fcr historische Sprachstufen des Deutschen. Journal for Language Technology and Computational Linguistics 28: 1\u201353.", "Dipper, Stefanie, Michael G\u00f6tze, Uwe K\u00fcssner & Manfred Stede. 2007. Representing and querying standoff XML. In G. Rehm, A. Witt & L. Lemnitzer (eds.), Datenstrukturen f\u00fcr linguistische Ressourcen und ihre Anwendungen. Gunter Narr Verlag, T\u00fcbingen.", "Macha, J\u00fcrgen, Elvira Topalovic, Iris Hille, Uta Nolting & Anja Wilke (eds.). 2005. Deutsche Kanzleisprache in Hexenverh\u00f6rprotokollen der Fr\u00fchen Neuzeit. De Gruyter, Berlin.", "Zeldes, Amir, Julia Ritz, Anke L\u00fcdeling & Christian Chiarcos. 2009. ANNIS: A search tool for multi-layer annotated corpora. In Proceedings of Corpus Linguistics 2009, Liverpool."]}
Misura di precisione della differenza di massa fra nuclei e anti-nuclei leggeri con l'esperimento ALICE a LHC
Precision measurement of the mass difference between light nuclei and anti-nuclei with the ALICE experiment at the LHC
Creators: name: Colocci, Manuel <1987>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: FIS/01 Fisica sperimentale

description: Con questo lavoro è stata effettuata una misura della differenza $\Delta \mu = \Delta (m / |z|)$ fra il rapporto massa su carica del deutone (d) e dell'anti-deutone (${\rm \overline{d}}$), e del nucleo di ${\rm ^{3}He}$ e di anti-${\rm ^{3}He}$ con l'esperimento ALICE ad LHC in collisioni Pb--Pb a un'energia nel centro di massa per coppia di nucleoni $\sqrt{s_{\rm NN}}=2.76~{\rm TeV}$. Le misure sono pari a ${\Delta \mu}_{\rm{d\bar{d}}}/{\mu}_{\rm{d}} = [0.9 \pm 0.5 (\rm{stat.}) \pm 1.4 (\rm{syst.})] \times 10^{-4}$ e ${\Delta \mu}_{\rm{^{3}He ^{3}\overline{He}}}/{\mu}_{\rm{^{3}He}} = [-1.2 \pm 0.9 (\rm{stat.}) \pm 1.0 (\rm{syst.})] \times  10^{-3}$. Combinando questi risultati con le misure esistenti delle masse dei (anti-)nucleoni, sono state estratte le corrispondenti differenze di energia di legame ${\Delta \varepsilon}_{\rm{d\bar{d}}}/{\varepsilon}_{\rm{d}} = -0.04 \pm 0.05(\rm{stat.}) \pm 0.12(\rm{syst.})$ e ${\Delta \varepsilon}_{\rm{^{3}He ^{3}\overline{He}}}/{\varepsilon}_{\rm{^{3}He}} = 0.24 \pm 0.16(\rm{stat.}) \pm 0.18(\rm{syst.})$. I risultati verificano, con una precisione senza precedenti, l'invarianza CPT nel settore dei nuclei leggeri.
description: With this work a measurement of the difference $\Delta \mu = \Delta (m / |z|)$ between the mass-over-charge ratio of deuteron (d) and anti-deuteron (${\rm \overline{d}}$), and ${\rm ^{3}He}$ and ${\rm ^{3}\overline{He}}$ nuclei, carried out with the ALICE experiment in Pb--Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}=~2.76~\rm{TeV}$ has been performed. The measurement yields ${\Delta \mu}_{\rm{d\bar{d}}}/{\mu}_{\rm{d}} = [0.9 \pm 0.5 (\rm{stat.}) \pm 1.4 (\rm{syst.})] \times 10^{-4}$ and ${\Delta \mu}_{\rm{^{3}He ^{3}\overline{He}}}/{\mu}_{\rm{^{3}He}} = [-1.2 \pm 0.9 (\rm{stat.}) \pm 1.0 (\rm{syst.})] \times  10^{-3}$. Combining these results with existing measurements of the masses of the (anti-)nucleons, the relative binding energy differences are extracted, ${\Delta \varepsilon}_{\rm{d\bar{d}}}/{\varepsilon}_{\rm{d}} = -0.04 \pm 0.05(\rm{stat.}) \pm 0.12(\rm{syst.})$ and ${\Delta \varepsilon}_{\rm{^{3}He ^{3}\overline{He}}}/{\varepsilon}_{\rm{^{3}He}} = 0.24 \pm 0.16(\rm{stat.}) \pm 0.18(\rm{syst.})$. These results test, to an unprecedented precision, the CPT invariance in the sector of light nuclei.
Supplementary document for Development of Mixed Pitch Grating for the Optical Addressing of Trapped Sr+ Ion with Data Analysis Techniques - 6382410.pdf
Creators: name: Lim, Yu Dian
name: Zhao, Peng
name: Hu, Liangxing
name: Guidoni, Luca
name: Likforman, Jean-Pierre
name: Tan, Chuan Seng
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Optical Technology

description: Python code to generate figures in the paper
Food Supply Chains and Eva.CAN Model: a Network Analytic Approach
Creators: name: Clemente, Flavia <1970>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: AGR/01 Economia ed estimo rurale

description: The research work leading to the drafting of this PhD thesis approaches the analysis of supply chains of products of animal origin from various productive species by using network analytic methods. In the studied analysis six supply chains are embedded in a single model which highlights all the interconnections that have little evidence in traditional models. This new model that we called Eva.CAN (Evaluation of Complex Agri-food Network Model) is a new concept model, the first complex network model for the agri-food production, the first to allow the application of Network Theory analysis methods. The initial hypothesis is that the various supply chains of products of animal origin have to be interpreted and analyzed as a whole, as a single complex system. The complex network is studied analyzing the adjacency matrix that constitutes the network with algorithms and methods extensively tested and validated. This analytical approach has already been applied with positive results in many research areas such as social networks, transport networks, the stylistic of writers and musicians, proteomics, pharmacology, medicine, biology, and many others. We apply this methodology to supply chains of products of animal origin and show a series of preliminary results. This method of study of food supply chains could be useful for an observatory, bringing to light slightly evident relations and becoming a strong support for policy-makers. It can also provide useful advices to individual actors on how to optimize their own supply chains. Finally, through an effective enumeration and evaluation of the relationships, a network model could be helpful in design of tracking and traceability systems.
Cool Beans
Creators: Pelc, Corrie
Publisher: name: University of Alberta Library
Year: 2014

For such a little thing, soybeans are big business. According to the American Soybean Association, 268 million metric tons of soybeans were produced globally. Brazil was the largest producer of soybeans in 2012, producing 83.5 million metric tons, followed by the United States (US) at 82.1 million metric tons.
title: The Development of the Inductive Database System VINLEN: A Review of Current Research
Creators: name: Cervone, Guido
name: Kaufman, Kenneth A.
name: Michalski, Ryszard S.
Publisher: name: George Mason University
Year: 2003
Subjects: subject: Machine learning
subject: Evolutionary computation
subject: Function optimization
subject: Learnable evolution model
subject: Engineering design
subject: Multistrategy learning

description: The recently introduced Learnable Evolution Model (LEM) represents a form of non-Darwinian evolutionary computation that is guided by a learning system. Specifically, LEM "genetically engineers" new populations via hypothesis formation and instantiation. Initial experiments with a preliminary implementation of LEM were highly encouraging, but tentative. This paper presents results from a new study in which LEM was systematically tested on a range of optimization problems and a complex real world design task. The study involved LEM2, a new implementation oriented toward function optimization, and ISHED, an implementation oriented toward engineering design. In all cases of function optimization, LEM2 strongly outperformed tested evolutionary algorithms in terms of the evolution length, measured by the number of fitness function evaluations needed to reach the desired solution. This evolutionary speedup also translated to an execution speedup whenever the fitness evaluation time was above a small threshold (a fraction of a second). The most important result of the study was that the advantage of LEM2 over the tested Darwinian-style evolutionary methods in terms of evolution length grew rapidly with the growth of the complexity of the optimized function. Experiments with ISHED on problems of optimizing heat exchangers (evaporators) produced designs that matched or exceeded designs produced by human experts. The obtained very strong results from the application of the LEM methodology to two diverse domains suggest that it may be useful also in other application domains, especially, those in which the fitness function evaluation is time-consuming or complex.
Between Philosophy and Economics. A critical Re-Examination of Carl Menger's Scientific Contribution
Creators: name: Collina, Beatrice <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: M-FIL/02 Logica e filosofia della scienza

description: The aim of this dissertation is to offer an innovative revising of the methodological and economic contributions of the Austrian economist Carl Menger (1840-1921), and to shed light on the actual influence of his work in the history of the discipline of economics. From an economic standpoint, Menger is renowned for his contribution to the “marginal revolution” of the 19th century. However, during the past decades several critics have questioned the originality of his position. Menger was accused of having made full use of typical elements of the Aristotelian tradition and having employed economic principles already developed by his contemporaries. From a methodological standpoint, Menger’s approach has been investigated mostly with regard to the so-called "Methodenstreit". However, this debate represents only one of the several relevant aspects at stake.
The discrepancies and partiality of these criticisms induced me to fully reconsider Menger’s perspective, without a priori embracing any of the contrasting positions emerged so far. To this aim, in this dissertation I am proposing a rational reconstruction of Menger’s approach.
Chapter 1 and Chapter 2 will be addressed to a survey of epistemological and methodological issues. I will especially discuss how Menger concretely applied his methodology to the study of political economy. Chapter 3 will be devoted to critically evaluate some widespread psychological readings of Menger’s work. Then, the last two Chapters will have instead a historical nature. In Chapter 4, I will investigate the neglected relationship between Menger and the German Historical School of Law. In Chapter 5, I will originally consider the mutual influences between Menger and his German colleagues. This multifaceted analysis of Menger’s contribution will also allow me to outline a fundamental contextualization of the state of affairs of the discipline of economics in the second half of the 19th century.