cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gravitational wave constraints on spatial covariant gravities
Creators: name: Zhu, Tao
name: Zhao, Wen
name: Wang, Anzhong
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The direct discovery of gravitational waves (GWs) from the coalescence of compact binary components by the LIGO/Virgo/KAGRA Collaboration provides an unprecedented opportunity for exploring the underlying theory of gravity that drives the coalescence process in the strong and highly dynamical field regime of gravity. In this paper, we consider the observational effects of spatial covariant gravities on the propagation of GWs in the cosmological background and obtain the observational constraints on coupling coefficients in the action of spatial covariant gravities from GW observations. We first decompose the GWs into the left- and right-hand circular polarization modes and derive the effects of the spatial covariant gravities on the propagation equation of GWs. We find that these effects can be divided into three classes: 1) frequency-independent effects on GW speed and friction, 2) parity-violating amplitude and velocity birefringences, and 3) a Lorentz-violating damping rate and dispersion of GWs. With these effects, we calculate the corresponding modified waveform of GWs generated by the coalescence of compact binaries. By comparing these new effects with the publicly available posterior samples or results from various tests of gravities with LIGO/Virgo/KAGRA data in the literature, we derive the observational constraints on coupling coefficients of the spatial covariant gravities. These results represent the most comprehensive constraints on the spatial covariant gravities in the literature.
description: 14 pages, 2 figures, and 4 tables. arXiv admin note: text overlap with arXiv:2210.05259; v2: version to appear in PRD
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CITICOLINE AND PIRACETAM IN BULK AND TABLET DOSAGE FORM BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Creators: name: Kanjarla Bhavani*, MRS. Bheemagoni Jyothi
Publisher: name: Zenodo
Year: 2023

description: Formulation and evaluation of floating tablets of Atenolol. In the present study the formulations were prepared by direct compression method using different proportions of HPMC K4M, HPMC K15M, and HPMC K100M as Swellable polymers. Sodium bicarbonate is used as buoyancy-imparting agent. The prepared formulations were evaluated for different parameters during its pre-compression and post-compression stages. The release characteristics of the formulations were studied in in-vitro conditions. The in-vitro dissolution study of formulation F8 was 99.41% within 12 h for good release and was fitted to kinetics of drug release for R2 value of Higuchi release mechanism model is 0.964. As an extension of this work for formulation F8, bioavailability, pharmacokinetic, and in-vivo studies can be done in future to develop as suitable candidate for a novel drug delivery system.
Key words: Atenolol, HPMC K4M, HPMC K15M, HPMC K100M and Floating Tablets.
Performance of diagnostic mammography differs in the United States and Denmark
Creators: name: Rosenberg, Robert D.
name: Miglioretti, Diana L.
name: Vejborg, Ilse
name: Yankaskas, Bonnie
name: Carney, Patricia A.
name: Gard, Charlotte C.
name: Jensen, Allan
name: Lynge, Elsebeth
name: Geller, Berta M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Diagnostic mammography is the primary imaging modality to diagnose breast cancer. However, few studies have evaluated variability in diagnostic mammography performance in communities, and none has done so between countries. We compared diagnostic mammography performance in community-based settings in the United States and Denmark. The performance of 93,585 diagnostic mammograms from 180 facilities contributing data to the U.S. Breast Cancer Surveillance Consortium (BCSC) from 1999 through 2001 was compared to that of all 51,313 diagnostic mammograms performed at Danish clinics in 2000. We used the imaging workup’s final assessment to determine sensitivity, specificity, and an estimate of accuracy: area under the receiver-operating characteristics (ROC) curve (AUC). Diagnostic mammography had slightly higher sensitivity in the United States (85%) than in Denmark (82%). In contrast, it had higher specificity in Denmark (99%) than in the United States (93%). The AUC was high in both countries: U.S. 0.91; and Denmark 0.95. Denmark’s higher accuracy may result from supplementary ultrasound examinations, which are provided to 74% of Danish women but only 37% to 52% of U.S. women. In addition, Danish mammography facilities specialize in either diagnosis or screening, possibly leading to greater diagnostic mammography expertise in facilities dedicated to symptomatic patients. Performance of community-based diagnostic mammography settings varied markedly between the two countries, indicating that it can be further optimized.
Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men
Creators: name: Moses, Stephen
name: Ndinya-Achola, J.O.
name: Meijer, Chris J.L.M.
name: Maclean, Ian
name: Snijders, Peter J.F.
name: Smith, Jennifer S.
name: Agot, Kawango
name: Veronesi, Giovanni
name: Bogaarts, Martijn
name: Bailey, Robert C.
name: Hudgens, Michael G.
name: Backes, Danielle M.
name: Agingu, Walter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Human papillomavirus (HPV) prevalence was estimated from 2,705 sexually active, uncircumcised, human immunodeficiency virus seronegative men aged 17–28 years in Kisumu, Kenya. HPV prevalence was 51.1% (95% confidence interval: 49.2 – 53.0%) in penile cells from the glans/coronal sulcus and/or shaft. HPV prevalence varied by anatomical site, with 46.5% positivity in the glans/coronal sulcus compared with 19.1% in the shaft (p<.0001). High-risk HPV was detected in 31.2% of glans and 12.3% of shaft samples (p<.0001). HPV16 was the most common type and 29.2% of men were infected with more than one HPV type. Risk factors for HPV infection included presence of C. trachomatis, N. gonorrhea, self-reported sexually transmitted infections, and less frequent bathing. Lifetime number of sexual partners and herpes simplex virus type-2 seropositivity were also marginally associated with HPV infection.
Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: Pooled analysis in five studies within the Ovarian Cancer Association Consortium
Creators: name: DiCioccio, Richard A.
name: Ramus, Susan J.
name: Menon, Usha
name: Gentry-Maharaj, Aleksandra
name: Gayther, Simon A.
name: Hogdall, Estrid
name: Whittemore, Alice S.
name: Lurie, Galina
name: Song, Honglin
name: Palmieri, Rachel T.
name: Goodman, Marc T.
name: Carney, Michael E.
name: Kjaer, Susanne Kruger
name: Wilkens, Lynne R.
name: Pharoah, Paul D. P.
name: McGuire, Valerie
name: Thompson, Pamela J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The association of invasive ovarian carcinoma risk with the functional polymorphism rs2228570 (aka rs10735810; FokI polymorphism) in the vitamin D receptor (VDR) gene was examined in 1820 white non-Hispanic cases and 3479 controls in a pooled analysis of five population-based case-control studies within the Ovarian Cancer Association Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Carriers of the rare T allele were at increased risk of ovarian carcinoma compared to women with the CC genotype in all studies combined; each copy of the T allele was associated with a modest 9% increased risk (OR=1.09; 95% CI:1.01–1.19; p=0.04). No significant heterogeneity among studies was observed (p=0.37) and, after excluding the dataset from the Hawaii study, the risk association for rs2228570 among replication studies was unchanged (OR=1.09; 95% CI: 1.00–1.19; p=0.06). A stronger association of rs2228570 with risk was observed among younger women (aged < 50 years versus 50 years or older) (p=0.04). In all studies combined, the increased risk per copy of the T allele among younger women was 24% (OR=1.24; 95% CI: 1.04–1.47; p=0.02). This association remained statistically significant after excluding the Hawaii data (OR= 1.20; 95% CI: 1.01–1.43; p=0.04). No heterogeneity of the association was observed by stage (p= 0.46), tumor histology (p=0.98), or time between diagnosis and interview (p=0.94). This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.
PHARMACOLOGICAL EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ALLIUM CEPA IN ANIMAL MODEL
Creators: name: Teki Venkata Srujana*, Dr. Sanapala Arun Kumar
Publisher: name: Zenodo
Year: 2023

description: People in modern society suffer from different psychiatric disorders, particularly the depression. The exact cause of depression is unknown, but researchers suggest that depression is due to imbalancing of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain. Factors that may contribute to depression include heredity, stress, chronic illnesses, certain personality traits and hormonal changes. However, several syntetic drugs are available in market, but all are associated with some limitations and there is an urgent need for alternative medications for these disorders.
Depression is a widely prevalent form of mental illnesses worldwide. It is commonly associated with sad mood, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, and low energy. Allium cepa has many medicinal properties, and are used in traditional medicine in the treatment of various medical conditions. This study was conducted to better understand the antidepressant activity of Allium cepa.
To evaluate the in vivo antidepressant activity of Methanolic extract of Allium cepa leave in Swiss albino mice. Methanolic extract of Allium cepa (EEAC) leaves was prepared by a continuous method using Soxhlet apparatus. The extract was subjected to phytochemical screening followed by acute oral toxicity studies in mice. EEAC in the doses of 100mg/Kg, 200mg/Kg and 400mg/Kg mg/kg body weight was administered to test groups Group 3, 4 and 5 respectively. Imipramine hydrochloride 15mg/kg body weight was administered to Standard group by oral route. Test group 3 received 100mg/kg (p.o). Control group received Normal saline 10ml/kg body weight. Antidepressant activity was identified by using modified Forced Swimming Test (FST) and Tail Suspension Test (TST). Period of immobility was observed in both the models which was indicative of anti-depressant activity. Standard statistical methods were used to evaluate the results. The results showed significant dose dependent antidepressant effect of EASL in Swiss albino mice for both the models in all the test groups (Test group I, II and III). EEAC possess significant antidepressant activity. However, further investigations are required to determine its active constituents and molecular level of target mechanism of the extract for further use in humans.
Keywords:
 
Allium cepa, Antidepressant activity, forced swim test, Open Field Test
Observation of size-dependent boundary effects in non-Hermitian electric circuits
Creators: name: Su, Luhong
name: Guo, Cui-Xian
name: Wang, Yongliang
name: Li, Li
name: Ruan, Xinhui
name: Du, Yanjing
name: Chen, Shu
name: Zheng, Dongning
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The non-Hermitian systems with the non-Hermitian skin effect (NHSE) are very sensitive to the imposed boundary conditions and lattice size, which leads to size-dependent non-Hermitian skin effects. Here, we report the experimental observation of NHSE with different boundary conditions and different lattice size in a unidirectional hopping model based on a circuit platform. The circuit admittance spectra and corresponding eigenstates are very sensitive to the presence of the boundary. Meanwhile, our experimental results show how the lattice size and boundary terms together affect the strength of NHSE. Therefore, our electric circuit provides a good platform to observe size-dependent boundary effects in non-Hermitian systems.
description: 8 pages, 4 figures, 4 tables
INTEGRATION AND IMPLEMENTATION OF PRECISION MEDICINE IN THE MULTIFACETED INFLAMMATORY BOWEL DISEASE
Creators: name: Masroor Ahmed, Muhammad Arif, Muhammad Afzal, Sehar Naeem, Sidra Naeem
Publisher: name: Zenodo
Year: 2023

description: Background: Inflammatory Bowel Disease (IBD) represents a multifaceted group of disorders that demand precise and personalized approaches to diagnosis and treatment. 
Methods: A retrospective cohort study was conducted, involving 220 patients diagnosed with IBD. Genetic and genomic analysis, immunological profiling, and assessment of environmental and lifestyle factors were performed. Inclusion criteria ensured the selection of a relevant patient population, while ethical considerations were upheld throughout data collection.
Results: Genetic analysis identified significant single-nucleotide polymorphisms (SNPs) associated with IBD susceptibility, emphasizing the genetic complexity of the disease. Immunological profiling revealed elevated pro-inflammatory cytokine levels, underlining the role of the immune system in IBD. Environmental factors, including dietary habits and geographical location, demonstrated associations with IBD risk.
Conclusion: The integration of precision medicine in IBD management offers personalized approaches to diagnosis and treatment. While these results are hypothetical, they underscore the need for further research and the potential for tailored interventions to improve IBD outcomes.
Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk
Creators: name: Martinez, Maria Elena
name: Joshi, Amit D.
name: Siegmund, Kimberly D.
name: Wang, Jun
name: Ahnen, Dennis J.
name: Stern, Mariana C.
name: Corral, Román
name: Lance, Peter
name: Haile, Robert W.
name: Marchand, Loïc Le
name: Sandler, Robert S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Diets high in red meat are established risk factors for colorectal cancer (CRC). Carcinogenic compounds generated during meat cooking have been implicated as causal agents. We conducted a family-based case-control study to investigate the association between polymorphisms in carcinogen metabolism genes (CYP1A2 -154A>C, CYP1B1 Leu432Val, CYP2E1 -1054C>T, GSTP1 Ile105Val, PTGS2 5UTR -765, EPHX1 Tyr113His, NAT2 Ile114Thr, NAT2 Arg197Gln and NAT2 Gly286Glu) and CRC risk. We tested for gene-environment interactions using case-only analyses (N = 577) and compared statistically significant results to those obtained using case-unaffected sibling comparisons (N = 307 sibships).
Improved torque and drag modeling using traditional and machine learning methods
Creators: name: Oyedere, Mayowa Olugbenga
name: 0000-0003-1224-5139
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Drilling
Torque and drag
Machine learning
Drilling optimization

description: During the drilling process, the drillstring inadvertently comes in contact with the wellbore generating frictional losses in the rotating moment (torque) and axial force (drag). These losses reduce the rotational power available at the drill bit, thus making adequate torque and drag modeling a critical piece in the drilling puzzle. The simplifying assumptions of the widely used soft-string model for torque and drag modeling make it less accurate for new complex well designs, creating the need for the use of the more robust stiff-string model. This first part of this dissertation focuses on a new approach to developing a stiff-string model that can be easily implemented for well planning. The stiff-string model addresses the pitfalls of the soft-string model by using cubic splines for its well-path trajectory. It solves the three coupled, non-linear ordinary differential equations that describe the motion of the drillstring at each survey point to account for the shear forces and bending stiffness. The stiff-string model is then applied to design four horizontal wells. Drilling Optimization has consistently generated research interest over the years because of the cost-saving benefits of improving drilling efficiency. Rate of penetration (ROP) and torque-on-bit (TOB) predictions have become critical to the successful drilling optimization efforts. The second part of this dissertation focuses on the prediction and optimization of TOB using five regression-based machine learning algorithms. TOB was modeled as a function of rotary speed (RPM), weight-on-bit (WOB), flow rate, pump pressure, and unconfined compressive strength (UCS). Three direct search optimization algorithms—Nelder Mead, differential evolution, and particle swarm optimization (PSO)—were used to optimize TOB. The final part of this dissertation introduces a novel approach to ROP and TOB prediction by modeling it as a classification problem with two regions (low and high ROP and TOB respectively) based on a user-defined threshold. Five different classification algorithms were implemented and compared using the area under curve (AUC) classification metric. Finally, a probability gradient tool was developed to help inform the drilling engineer on the best combination of WOB and RPM to yield the desired drilling performance
To what extent are the assessments by legal academics who critiqued the Irish personal injury reforms (PIAB & related measures) defensible in light of the outcomes? A case study
Creators: name: Dowling, Dorothea
Publisher: name: University of Westminster
Year: 2020

description: This dissertation supports the hypothesis that the current debate about ‘a compensation culture’ as against ‘a negligence culture’ is missing a third dimension of ‘professional regulatory culture’ that has not been accorded sufficient attention in the tort literature to date. My original contribution to knowledge also demonstrates that many of the assertions by insurers that trends in premium rates for liability insurance are almost entirely driven by tort claims is largely a fallacy. The reason this is important is because there is often a ‘taken for granted view’ that the frequency of accidents causes claims which result in escalating insurance costs. That in turn can lead to calls for further tort reforms in many jurisdictions but the real mischief has not been properly identified, as revealed in this significant research. Proposals in 2002 to reform the Irish compensation system for negligently inflicted personal injury provoked a flurry of concerns from academics. A number of reservations were raised about the potential for success and the risks to fairness for claimants. The majority professed a preference for the status quo but they were largely operating from an evidence free environment and many relied on little more than anecdotes from the legal professions. However, their analyses also provided a unique opportunity to identify what tort scholars considered to be the key markers of an optimal redress system. To address those academic concerns the scope of this case study interrogated data for an entire nation, comprising of over 6.7 million claims with a value of €34bl and triangulated those trends with analyses of accident frequency as against insurance pricing and profitability over several decades. The role of the media in negative public perceptions of negligence law is also addressed. These wide-ranging and robust statistical analyses make a substantial contribution to address a gap that it is acknowledged exists in the tort literature. While this thesis concludes that many of the academic concerns about the reforms were misplaced, it reveals that there are layers of interlocking relationships to which tort theory does not currently ascribe sufficient weight.
Additional file 1 of Spot urinary microalbumin concentration, metabolic syndrome and type 2 diabetes: Tehran lipid and glucose study
Creators: name: Gaeini, Zahra
name: Bahadoran, Zahra
name: Mirmiran, Parvin
name: Norouzirad, Reza
name: Ghasemi, Asghar
name: Azizi, Fereidoun
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 1: Supplementary Table 1. Odds ratios and 95% CIs of different combinations of MetS components across tertiles of urinary microalbumin concentration.
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice
Creators: name: Kosyk, Oksana
name: Tumurbaatar, Batbayar
name: Melnyk, Stepan B.
name: Jeannot, Emmanuelle
name: Weinman, Steven A.
name: Tryndyak, Volodymyr
name: Boorman, Gary A.
name: Rusyn, Ivan
name: Pogribny, Igor P.
name: Bradford, Blair U.
name: Shymoniak, Svitlana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Viral hepatitis and aflatoxin B1 (AFB1) exposure are common risk factors for hepatocellular carcinoma (HCC). The incidence of HCC in individuals co-exposed to hepatitis C (HCV) or B virus and AFB1 is greater than could be explained by the additive effect, yet the mechanisms are poorly understood due to lack of an animal model. This study investigated the outcomes and mechanisms of combined exposure to HCV and AFB1. We hypothesized that HCV transgenic (HCV-Tg; expressing core, E1, E2, and p7, nucleotides 342–2771) mice will be prone to hepatocarcinogenesis when exposed to AFB1. Neonatal (7 days old) HCV-Tg or C57BL/6J wild-type mice were exposed to AFB1 (6 μg/g bw) or tricaprylin vehicle (15 μl/g bw) and male offspring were followed for up to 12 months. No liver lesions were observed in vehicle-treated wild type or HCV-Tg mice. Tumors (adenomas or carcinomas) and preneoplastic lesions (hyperplasia or foci) were observed in 22.5% (9 of 40) of AFB1-treated wild-type mice. In HCV-Tg, the incidence of tumorous or pre-tumorous lesions was significantly elevated (50%, 18 of 36), with the difference largely due to a 2.5-fold increase in the incidence of adenomas (30.5% vs 12.5%). While oxidative stress and steato-hepatisis were observed in both AFB1-treated groups, molecular changes indicative of the enhanced inflammatory response and altered lipid metabolism were more pronounced in HCV-Tg mice. In summary, HCV proteins core, E1, E2 and p7 are sufficient to reproduce the co-carcinogenic effect of HCV and AFB1 which is a known clinical phenomenon.
Decolonising the Informal: Discourse, Everyday Life, and the Politics of Urbanisation in Windhoek, Namibia
Creators: name: Luehl, Phillip
Publisher: name: University of Westminster
Year: 2020

description: In contemporary post-colonial Namibia, the concept of informality is widely applied with reference to the ‘informal economy’ and ‘informal settlements’, which are rapidly overtaking formal urbanisation processes inherited from colonial times. All the while, conventional professional spatial practices remain structurally elitist and seem ineffectual in settings of ‘urban informality’, which largely overlap with the lived experience of the black urban poor. Urban theory continues to reinforce a binary conceptualisation in which ‘informality’ remains framed as the non-formal, emphasising what it is not rather than providing a conceptual framework for what it is. This study is threefold: firstly, I investigate understandings of ‘informality’ throughin-depth interviews with professional spatial practitioners in the governmental, NGO and private sectors. Secondly, I reconceptualise ‘informality’ as everyday spatial practice based on participant observation at the “Herero Mall” ‘informal market’ in Windhoek. Thirdly, I give account of my involvement in a co-productive spatial intervention at the Herero Mall with local traders. Through these three approaches, I found that the temporal overlap between Namibia’s decolonisation (from the late 1970s until Independence in 1990) and the mainstreaming of the concept of ‘informality’ in urban theory provided the conditions of emergence for ‘informality’ to become a discursive practice. By discursively constructing the world of the ‘informal’ as the binary opposite of what is considered formal and legitimate, its actors and practices are delegitimised and thus continue to be structurally excluded. At the same time, I argue that the ‘informal’ everyday spatial and economic practices of the subaltern is a form of resistance to formal enclosure, weaving together fragments of colonial urbanisation into a decolonising urbanism. I argue that this form of alter-urbanisation provides a point of departure for an alternative professional spatial practice, the outlines of which I trace through reflecting on a co-productive spatial intervention at the Herero Mall.
Large U(1) charges from flux breaking in 4D F-theory models
Creators: name: Li, Shing Yan
name: Taylor, Washington
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the massless charged spectrum of U(1) gauge fields in F-theory that arise from flux breaking of a nonabelian group. The U(1) charges that arise in this way can be very large. In particular, using vertical flux breaking, we construct an explicit 4D F-theory model with a U(1) decoupled from other gauge sectors, in which the massless/light fields have charges as large as 657. This result greatly exceeds prior results in the literature. We argue heuristically that this result may provide an upper bound on charges for light fields under decoupled U(1) factors in the F-theory landscape. We also show that the charges can be even larger when the U(1) is coupled to other gauge groups.
description: 29 pages, 1 figure; v2: Published version in JHEP
Modelling the accretion and feedback of supermassive black hole binaries in gas-rich galaxy mergers
Creators: name: Liao, Shihong
name: Johansson, Peter H.
name: Mannerkoski, Matias
name: Irodotou, Dimitrios
name: Rizzuto, Francesco Paolo
name: McAlpine, Stuart
name: Rantala, Antti
name: Rawlings, Alexander
name: Sawala, Till
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We introduce a new model for the accretion and feedback of supermassive black hole (SMBH) binaries to the KETJU code, which enables us to resolve the evolution of SMBH binaries down to separations of tens of Schwarzschild radii in gas-rich galaxy mergers. Our subgrid binary accretion model extends the widely used Bondi--Hoyle--Lyttleton accretion into the binary phase and incorporates preferential mass accretion onto the secondary SMBH, which is motivated by results from small-scale hydrodynamical circumbinary disc simulations. We perform idealised gas-rich disc galaxy merger simulations using pure thermal or pure kinetic active galactic nuclei (AGN) feedback. Our binary accretion model provides more physically motivated SMBH mass ratios, which are one of the key parameters for computing gravitational wave (GW) induced recoil velocities. The merger time-scales of our simulated SMBH binaries are in the range $t_{\rm merge}{\sim} 10$--$400$ Myr. Prograde in-plane equal-mass galaxy mergers lead to the shortest merger time-scales, as they experience the strongest starbursts, with the ensuing high stellar density resulting in a rapid SMBH coalescence. Compared to the thermal AGN feedback, the kinetic AGN feedback predicts longer merger time-scales and results in more core-like stellar profiles, as it is more effective in removing gas from the galaxy centre and quenching star formation. This suggests that the AGN feedback implementation plays a critical role in modelling SMBH coalescences. Our model will be useful for improving the modelling of SMBH mergers in gas-rich galaxies, the prime targets for the upcoming LISA GW observatory.
description: 28 pages, 13 main + 6 appendix figures, accepted for publication in MNRAS
An Aspirations-led Capabilities Approach to Women’s Career Pathways in Quantity Surveying
Creators: name: Bowes, Denise
Publisher: name: University of Westminster
Year: 2020

description: This thesis explores the career experiences of female quantity surveyors (QSs) in the UK construction industry and examines how they can pursue their aspirations within the structure and the culture of its organisations. There is a lack of research about the careers of female QSs, although there is a lot that focuses on women in the construction industry generally. Research about women’s careers in construction has focused on their underachievement and lack of career success. However, these are based on traditional career patterns with an expectation of upwards progression. In using the Capabilities Approach (CA) of Amartya Sen, the research enables understanding of how women can pursue their aspirations and achieve their own definitions of career success. A capability set for female QSs was established, combinations of capabilities within the set enable pursuit of any stated aspiration. A mixed methods research methodology was adopted, comprising interviews with twenty-seven female QSs working for Network Rail, supplemented by a questionnaire survey of female QSs throughout the wider construction industry. Structural and cultural enablers and constraints were examined by means of interviews with fourteen representatives from a range of construction organisations. The findings build on and contribute to existing knowledge about women in the construction industry. A key finding is the identification of three career pathways. However, female QSs’ aspirations mean that their pathways are not clearly determined, and trajectories are not necessarily linear. For female QSs, career success is having the ability to choose the aspirations they pursue and to change and adapt as circumstances dictate. The research reflects that organisations can either enable or constrain the pursuit of aspirations. Although there are a range of organisations that female QSs can work for, their size and structure are significant in career development and, while many organisations have comprehensive equality policies, their implementation by line managers varies and gender stereotyped assumptions about female QSs’ careers remain. This research also contributes to existing career theory, particularly why a ‘one size fits all’ mechanism of evaluating career trajectories and career success is unsatisfactory. It also establishes that aspirations and individual definitions of career success are instrumental in determining career pathways where previously only organisational factors have been considered.
Male circumcision is associated with a lower prevalence of human papillomavirus-associated penile lesions among Kenyan men
Creators: name: Snijders, Peter J.F.
name: Bailey, Robert C.
name: Meijer, Chris J.L.M.
name: Hogewoning, Cornelis J.A.
name: Backes, Danielle M.
name: Agot, Kawango
name: Moses, Stephen
name: Smith, Jennifer S.
name: Hayombe, Juma
name: Bleeker, Maaike C.G.
name: Hudgens, Michael G.
name: Ndinya-Achola, J.O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden of cervical cancer. Visual inspection of the penis was conducted using a colposcope at the 24-month visit among participants in a randomized controlled trial of male circumcision in Kenya, from May 2006 to October 2007. All photos were read independently by two observers for quality control. Penile exfoliated cells sampled from the glans/coronal sulcus and the shaft were tested for HPV DNA using GP5+/6+ PCR and for HPV16, 18 and 31 viral loads using a real time PCR assay. Of 275 men, 151 were circumcised and 124 uncircumcised. The median age was 22 years. Circumcised men had a lower prevalence of flat penile lesions (0.7%) versus uncircumcised (26.0%); adjusted odds ratio [OR]=0.02; 95% confidence interval [CI]: 0.003–0.1). Compared to men who were HPV-negative, men who were HPV DNA positive (OR=6.5; 95%CI: 2.4–17.5) or who had high HPV16/18/31 viral load (OR=5.2; 95%CI: 1.1–24.4) had higher odds of flat penile lesions. Among men with flat penile lesions, HPV56 (29.0%) and 16 (25.8%) were the most common types. Flat penile lesions are much more frequent in uncircumcised men, and associated with higher prevalence of HPV and higher viral loads. This study suggests that circumcision reduces the prevalence of HPV-associated flat lesions and may ultimately reduce male to female HPV transmission.
snm3C-seq3 Beckman i7 Protocol
Creators: name: Bartlett, Anna
name: Castanon, Rosa
name: Luo, Chongyuan
name: Ecker, Joseph
Publisher: name: Zenodo
Year: 2023

description: We developed a single-nucleus multiomic sequencing technology (snm3C-seq3) to assay both the methylome and chromatin conformation from within the same cell. We further adapted this protocol to allow for mass-scale assessment, assaying thousands of cells at a time.
A pressure-robust discretization of Oseen's equation using stabilization in the vorticity equation
Creators: name: Ahmed, ##!Error: Attribute  Unknown!##
name: Barrenechea, Gabriel R
name: Burman, Erik
name: Guzmán, Johnny
name: Linke, Alexander
name: Merdon, Christian
Publisher: name: Weierstrass Institute
Year: 2020
Subjects: subject: incompressible Navier--Stokes equations
subject: divergence-free mixed finite element methods
subject: pressure-robustness
subject: convection stabilization
subject: Galerkin least squares
subject: vorticity equation
subject: 65N30
subject: 65N12
subject: 76D07

description: Discretization of Navier--Stokes' equations using pressure-robust finite element methods is considered for the high Reynolds number regime. To counter oscillations due to dominating convection we add a stabilization based on a bulk term in the form of a residual-based least squares stabilization of the vorticity equation supplemented by a penalty term on (certain components of) the gradient jump over the elements faces. Since the stabilization is based on the vorticity equation, it is independent of the pressure gradients, which makes it pressure-robust. Thus, we prove pressureindependent error estimates in the linearized case, known as Oseen's problem. In fact, we prove an O(hk+1/2) error estimate in the L2-norm that is known to be the best that can be expected for this type of problem. Numerical examples are provided that, in addition to confirming the theoretical results, show that the present method compares favorably to the classical residual-based SUPG stabilization.
title: Study satisfaction among university students during the COVID-19 pandemic: Longitudinal development and personal-contextual predictors
Creators: name: Gadosey, Christopher K.
name: Grunschel, Carola
name: Kegel, Lena S.
name: Schnettler, Theresa
name: Turhan, Derya
name: Scheunemann, Anne
name: Bäulke, Lisa
name: Thomas, Laura
name: Buhlmann, Ulrike
name: Dresel, Markus
name: Fries, Stefan
name: Leutner, Detlev
name: Wirth, Joachim Thorsten Christian
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 150 Psychology

description: The COVID-19 pandemic challenges the well-being and academic success of many students. Yet, little is known about students’ study satisfaction during the COVID-19 pandemic, a multilayered construct which accounts for students’ subjective cognitive well-being and academic success. Besides, previous studies on study satisfaction are mostly cross-sectional and hardly consider the distinct subdimensions of this construct. Therefore, our main goal in this study was to shed light on the understudied development of the subdimensions of study satisfaction (i.e., satisfaction with study content, conditions of studying, and coping with study-related stress) in two semesters amid the COVID-19 pandemic. Additionally, we examined how particular personal (i.e., gender, age, GPA, intrinsic motivation, motivational cost, and academic procrastination) and contextual (i.e., loneliness) factors are related to these subdimensions. We conducted two panel studies with convenience and purposeful samples of university students in Germany (Nstudy1 = 837; Nstudy2 = 719). Participants responded online to questions on each of the subdimensions of study satisfaction at the beginning, middle, and end of each semester but responded to measures of personal and contextual factors only at the beginning of each semester. In both studies, manifest growth curve models indicated a decrease in all subdimensions of study satisfaction as the semester progressed. Generally, gender (male) and intrinsic motivation were positive predictors but age (younger students), motivational cost, and loneliness were negative predictors of different subdimensions of study satisfaction – particularly satisfaction with study content. Overall, motivational costs and loneliness were the most consistent predictors of all subdimensions of study satisfaction across both studies. Our findings provide support for the understanding that study satisfaction could diminish in the face of challenging situations such as in this pandemic. The present study also highlights certain personal and contextual factors that relate to study satisfaction and calls for intensive research into the multidimensional construct of study satisfaction.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Nuclear factor kappa B pathway associated biomarkers in AIDS defining malignancies
Creators: name: Sin, Sang-Hoon
name: Dittmer, Dirk P.
name: Harrington, William
name: Ramos, Juan-Carlos
name: Roy, Debasmita
name: Staudt, Michelle R.
name: Vahrson, Wolfgang
name: Dezube, Bruce J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Nuclear Factor kappa B (NFkB) pathway is essential for many human cancers. Therapeutics such as bortezomib (Velcade™), which interfere with nuclear factor NF-kappa-B(NFkB)signaling are of great clinical interest. NFkB signaling, however, is multifaceted and variable among tissues, developmental, and disease entities. Hence, targeted biomarkers of NFkB pathways are of prime importance for clinical research. We developed a novel real-time qPCR-based NFkB array. Only mechanistically validated NFkB targets were included. We then used random-forest classification to define individual genes and gene combinations within the NFkB pathways that define viral lymphoma subclasses as well as Kaposi sarcoma (KS). Few NFkB targets emerged that were universally present in all tumor types tested, underscoring the need for additional tumor-type specific biomarker discovery. (i) We uncovered tissue of origin-specific tumor markers, specifically CD69, CSF-1, and complement factor B (C1QBP)for PEL; IL1-beta, cyclinD3 and CD48for KS. We found that IL12, jun-B, msx-1 and thrombospondin 2 were associated with EBV co-infection in PEL. (ii) We defined the NFkB signature of Epstein-Barr virus (EBV)positive AIDS-associated Burkitt lymphoma(BL). This signature identified CCR5 as the key marker. (iii) This signature differed from EBV negative BL consistent with the idea that EBV not only activates NFkB activity but that this virus also reprograms NFkB signaling towards different targets.
Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies
Creators: name: Qiao, You-Lin
name: Sellors, John W.
name: Li, Long-Yu
name: Hu, Shang-Ying
name: Zhang, Xun
name: Wei, Li-Hui
name: Li, Chang-Qing
name: Xu, Ai-Di
name: Belinson, Jerome L.
name: Lewkowitz, Adam K.
name: Zhang, Wen-Hua
name: Pan, Qin-Jing
name: Franceschi, Silvia
name: Zhang, Qing-Ming
name: Zhao, Fang-Hui
name: Smith, Jennifer S.
name: Chen, Feng
name: Wu, Rui-Fang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: High-risk (HR) human papillomavirus (HPV) prevalence has been shown to correlate well with cervical cancer incidence rates. Our study aimed to estimate the prevalence of HR-HPV and cervical intraepithelial neoplasia (CIN) in China and indirectly inform on the cervical cancer burden in the country. 30,207 women from 17 population-based studies throughout China were included. All women received HPV DNA testing (HC2, Qiagen), visual inspection with acetic acid, and liquid-based cytology. Women positive for any test received colposcopy-directed or 4-quadrant biopsies. 29,579 women had HR-HPV testing results, of whom 28,761 had biopsy-confirmed (9019, 31.4%) or assumed (19,742, 68.6%) final diagnosis. Overall crude HR-HPV prevalence was 17.7%. HR-HPV prevalence was similar in rural and urban areas but showed dips in different age groups: at age 25–29 years (11.3%) in rural and at age 35–39 (11.3%) in urban women. In rural and urban women, age-standardized CIN2 prevalence was 1.5% (95%CI: 1.4%–1.6%) and 0.7% (95%CI: 0.7%–0.8%), and CIN3+ prevalence was 1.2% (95%CI: 1.2%–1.3%) and 0.6% (95%CI: 0.5%–0.7%), respectively. Prevalence of CIN3+ as a percentage of either all women or HR-HPV positive women steadily increased with age, peaking in 45–49 year-old women. High prevalence of HR-HPV and CIN3+ was detected in both rural and urban China. The steady rise of CIN3+ up to the age group 45–49 is attributable to lack of lesion removal through screening. Our findings document the inadequacy of current screening in China while indirectly raising the possibility that the cervical cancer burden in China is under-reported.
Characterization of plasma-treated OMPs containing polluted water samples
Creators: name: Kumar, Amit
Publisher: name: Zenodo
Year: 2022

description: The files provide raw data collected after analyzing all plasma-treated selected OMPs. The UV/Vis spectrophotometer was used to analyze dyes containing plasma treated liquid samples, and the absorbance curve was recorded and reported (.CSV). Pharmaceutical plasma treatment solutions were evaluated using HPLC. After the analysis, the raw files (.CSV) are recorded. Orbitrap-LC-MS was used to evaluate some of the Diclofenac plasma-treated solutions. The raw Orbitrap data (.XLSX) that was taken is attached.
Vitamin D receptor polymorphisms in patients with cutaneous melanoma
Creators: name: Orlow, Irene
name: From, Lynn
name: Dwyer, Terence
name: Paine, Susan
name: Roy, Pampa
name: Gallagher, Richard P.
name: Berwick, Marianne
name: Yoo, Sarah
name: Reiner, Anne S.
name: Armstrong, Bruce K.
name: Kricker, Anne
name: Patel, Himali
name: Gruber, Stephen B.
name: Rosso, Stefano
name: Millikan, Robert C.
name: Busam, Klaus
name: Thomas, Nancy E.
name: Marrett, Loraine D.
name: Kanetsky, Peter A.
name: Begg, Colin B.
name: Anton-Culver, Hoda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The vitamin D receptor (VDR) gene has been associated with cancer risk, but only a few polymorphisms have been studied in relation to melanoma risk and the results have been inconsistent. We examined 38 VDR gene SNPs in a large international multi-center population-based case-control study of melanoma.
Normal ordering of three-nucleon interactions for ab initio calculations of heavy nuclei
Creators: name: Hebeler, K.
name: Durant, V.
name: Hoppe, J.
name: Heinz, M.
name: Schwenk, A.
name: Simonis, J.
name: Tichai, A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Three-nucleon (3N) interactions are key for an accurate solution of the nuclear many-body problem. However, fully taking into account 3N forces constitutes a computational challenge and hence approximate treatments are commonly employed. The method of normal ordering has proven to be a powerful tool that allows to systematically include 3N interactions in an efficient way, but traditional normal-ordering frameworks require the representation of 3N interactions in a large single-particle basis, typically necessitating a truncation of 3N matrix elements. While this truncation has only a minor impact for light and medium-mass nuclei, its effects become sizable for heavier systems and hence limit the scope of \textit{ab initio} calculations. In this work, we present a novel normal-ordering framework that allows to circumvent this limitation by performing the normal ordering directly in a Jacobi basis. We discuss in detail the new framework, benchmark it against established results, and present calculations for ground-state energies and charge radii of heavy nuclei, such as $^{132}$Sn and $^{208}$Pb.
description: 13 pages, 9 figures, 2 tables, published version
Additional file 1 of The kinome, cyclins and cyclin-dependent kinases of pituitary adenomas, a look into the gene expression profile among tumors from different lineages
Creators: name: Taniguchi-Ponciano, Keiko
name: Portocarrero-Ortiz, Lesly A.
name: Guinto, Gerardo
name: Moreno-Jimenez, Sergio
name: Gomez-Apo, Erick
name: Chavez-Macias, Laura
name: Peña-Martínez, Eduardo
name: Silva-Román, Gloria
name: Vela-Patiño, Sandra
name: Ordoñez-García, Jesús
name: Andonegui-Elguera, Sergio
name: Ferreira-Hermosillo, Aldo
name: Ramirez-Renteria, Claudia
name: Espinosa-Cardenas, Etual
name: Sosa, Ernesto
name: Espinosa-de-los-Monteros, Ana Laura
name: Salame-Khouri, Latife
name: Perez, Carolina
name: Lopez-Felix, Blas
name: Vargas-Ortega, Guadalupe
name: Gonzalez-Virla, Baldomero
name: Lisbona-Buzali, Marcos
name: Marrero-Rodríguez, Daniel
name: Mercado, Moisés
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplementary figure 1. Cell cycle stages gene expression in pituitary adenomas. Panel A) shows the G1 stage of the cell cycle gene expression profile in the three lineages of pituitary tumors and control gland. Panel B) display the G1/S transition gene expression profile, C) portray the G2 expression profile and D) the G2/M transition gene expression profile. Blue depicts the control gland, red the NR5A1 tumors, green the POU1F1 tumors and yellow the TBX19 tumors respectively.
Additional file 1 of Improving outcomes among young adults with type 1 diabetes: the D1 Now pilot cluster randomised controlled trial
Creators: name: Morrissey, Eimear C.
name: Byrne, Molly
name: Casey, Bláthín
name: Casey, Dympna
name: Gillespie, Paddy
name: Hobbins, Anna
name: Lowry, Michelle
name: McCarthy, Elizabeth
name: Newell, John
name: Roshan, Davood
name: Sharma, Shikha
name: Dinneen, Sean F.
Publisher: name: figshare
Year: 2022
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1.