cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanistic studies of natural ribozymes and a synthetic DNAzyme
Creators: name: Thomas, Jason M.
Publisher: name: University of British Columbia
Year: 2009

description: This thesis reports the results of experiments designed to help elucidate the catalytic mechanisms of three RNA cleaving nucleic acid catalysts (the 9₂₅-11 DNAzyme, and the hammerhead and hairpin ribozymes). A number of enzymological and chemical probing experiments were employed in this regard, which were inspired by antecedent studies of RNA cleaving protein enzymes. First, a novel affinity labeling technique for nucleic acid catalysts was developed to probe general base catalysis. The affinity labeling substrate analogues bear a 2'-bromoacetamide modification at their cleavage sites. The second mechanistic probe employed was 5'-bridging phosphorothioate (S-link) substrate analogues, in which sulphur replaces the native oxygen leaving group. Investigation of S-link substrate cleavage in the context of active site mutations provided insight into general acid catalysis. A novel, simplified method for synthesizing S-link substrates is also presented. Several other experiments provided further mechanistic insight including pH-rate profiling, pKa perturbation, and the use of nonbridging phosphorothioate substrates. Using many of the aforementioned experiments, the catalytic mechanism 9₂₅-11 DNAzyme (a synthetically modified DNAzyme that contains unnatural protein-like functional groups) was investigated in detail. The data suggest that 9₂₅-11 uses its synthetic functional groups to mimic the active site mechanism of the protein enzyme RNaseA. Affinity labeling, pKa perturbation, and S-link cleavage experiments were also applied to the hammerhead ribozyme. The affinity labeling data suggest that the deprotonated N1 position of G12 acts as a general base catalyst. The results of pKa perturbation and S-link cleavage experiments provide strong evidence for a unique general acid mechanism in the hammerhead ribozyme. Therein, metal coordination is used to acidify a 2'-hydroxyl and thereby improve its ability to act as general acid. Finally, affinity labeling was used to characterize the role of hairpin ribozyme G8 residue, which occupies a similar structural position to the hammerhead G12 residue. Affinity labeling indeed identified G8 as a potential general base in the hairpin ribozyme. The properties of the hairpin and hammerhead affinity labeling reactions are compared and the mechanistic implications are discussed.
Additional file 4: of Allopatric integrations selectively change host transcriptomes, leading to varied expression efficiencies of exotic genes in Myxococcus xanthus
Creators: name: Zhu, Li-Ping
name: Yue, Xin-Jing
name: Han, Kui
name: Li, Zhi-Feng
name: Lian-Shuai Zheng
name: Xiu-Nan Yi
name: Wang, Hai-Long
name: Zhang, You-Ming
name: Li, Yue-Zhong
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Table S2. Significantly up- and down-regulated Myxococcus genes in different recombinants.
Palaeoneura durwest Triapitsyn 2010
Creators: name: Huber, John T.
name: Read, Jennifer D.
name: Triapitsyn, Serguei V.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mymaridae
Palaeoneura
Palaeoneura durwest

description: Palaeoneura durwest Triapitsyn, 2010
Palaeoneura durwest Triapitsyn, 2010: 73. Holotype ♀ (UCRC). TL: Guatemala, Sumpango, Durwest Farm. Triapitsyn, 2010: 76 (key); Triapitsyn, 2018b: 37 (key).
Distribution. USA: FL.
description: Published as part of Huber, John T., Read, Jennifer D. & Triapitsyn, Serguei V., 2020, Illustrated key to genera and catalogue of Mymaridae (Hymenoptera) in America north of Mexico, pp. 1-411 in Zootaxa 4773 (3) on page 283, DOI: 10.11646/zootaxa.4773.1.1, http://zenodo.org/record/3821373
title: The Creative Arts, Environmental Crises & Well-Being in Globalized Place: Methodological Considerations for an Ecocritical Mode of Practice-Based Research
Creators: name: Warren, Brad
name: West, Patrick
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2015

description: [From Introduction] Problems pertaining to environmental and ecological well-being are increasingly having effects on a global scale; climate change is the most obvious example of this, but not the only one (the pollution of the oceans and transnational light pollution are others). Our paper argues that individual and community well-being in general, which is always directly or indirectly related to specifically environmental or ecological well-being at the global scale, can be augmented through the introduction of Creative Arts activities and products into local communities.
Synthesis on solid phase of a bicyclic octapeptide amatoxin
Creators: name: Blanc, Antoine
Publisher: name: University of British Columbia
Year: 2009

description: The α-amanitin is an excellent template for use in the design of a chemical library on solid phase in order to study the mechanisms involved in the regulation of transcription. Indeed, α-amanitin selectively inhibits with high affinity the RNA Polymerase II. The α-amanitin belongs to the amatoxin family which is characterized by a defined rigid bicyclic structure consisting of a head-to-tail cyclized octapeptide, with a transannular linkage known as a tryptathionine bridge. The latter is made via the Savige-Fontana tryptathionylation of the oxidized tryptophan derivative 3α-hydroxypyrrolo[2,3-b]indoline in neat TFA. Therefore, in order to achieve the synthesis of an α-amanitin-based library on solid phase, the linker must be stable both in TFA and during the peptide synthesis. Such a linker was found in the tartrate-based linker. As proof of this concept, following completion of the linker synthesis on solid phase, the linear octapeptide precursor of Pro²-Glu³-S-deoxo-amaninamide was prepared by standard Fmoc/tert-Bu SPPS. The tryptathionine bridge was achieved by the Savige-Fontana reaction and the second cyclization was performed by a head-to-tail macrolactamization, all on PEGA resin. The bicyclic octapeptide was cleaved off from the linker with the mild sodium periodate oxidant, purified by RP-HPLC and characterized by HRMS (ESI) and UV spectra.
Additional file 2: Table S2. of Rates of pneumonia among children and adults with chronic medical conditions in Germany
Creators: name: Pelton, Stephen
name: Shea, Kimberly
name: Farkouh, Raymond
name: Strutton, David
name: Braun, Sebastian
name: Jacob, Christian
name: Klok, Rogier
name: Gruen, Elana
name: Weycker, Derek
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: High risk-conditions: Diagnosis, procedure, and drug codes for algorithms identifying baseline risk factors and study measures. (DOC 70 kb)
Von der Schule in den Weltraum – Experimente mit dem P51™-Fluoreszenz-Viewer
Creators: name: Block, Sarah
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Fast 70 Jahre nachdem von Rosalind Franklin und ihrem Doktoranden Raymond Gosling das berühmte Foto 51, die Röntgenstruktur der DNA, aufgenommen wurde, umkreist nun „P51“ die Erde. Seit 2021 können Astronauten den P51TM-Viewer der Firma miniPCR® auf der Internationalen Raumstation ISS nutzen, um fluoreszierende Biomoleküle sichtbar zu machen. Nun soll das kleine Gerät auch Einzug in deutsche Klassenzimmer halten. Was können diese kleinen Schachteln?
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Step by Step – ein Bestimmungsschlüssel der häufigsten Insektenordnungen für Einsteiger
Creators: name: Clausen, Simon
name: Seeling, Ronja
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Die Bestimmung von Insekten stellt so manchen Einsteiger aufgrund der enormen morphologischen Vielfalt dieser Gruppe vor große Herausforderungen. Um taxonomischen Einsteigern eine sichere Orientierung in der Insektenvielfalt zu ermöglichen, wird im Folgenden ein Bestimmungsschlüssel der in Deutschland am häufigsten vorkommenden Insektenordnungen vorgestellt.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Additional file 2: of Serious electronic games as behavioural change interventions in healthcare-associated infections and infection prevention and control: a scoping review of the literature and future directions
Creators: name: Castro-SĂĄnchez, Enrique
name: Yiannis Kyratsis
name: Iwami, Michiyo
name: Rawson, Timothy
name: Holmes, Alison
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Flow chart depicting the selection of studies. Flow chart depicting the selection of studies in the scoping review. (DOCX 86Â kb)
Wissenschaftliche Erkenntnis gegen Mythen und Ideologien
Creators: name: Kunz, Werner
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Wissenschaft unterliegt anderen Denkgesetzen als der Glaube. Ideologien sind Weltanschauungen, die vorgeben, für das Leben und die Welt die richtige Lösung zu haben. Die Wissenschaft dagegen räumt ein, Vieles bis heute nicht verstanden zu haben und dass das, was sie lehrt, auch falsch sein könnte. Das wissenschaftliche Denken unterscheidet sich von Mythen und Ideologien durch die Überprüfbarkeit. Der Siegeszug der Wissenschaft ist darauf zurückzuführen, dass durch ihre Denkgesetze Resultate gewonnen werden, die Voraussagen in die Zukunft erlauben, die dann tatsächlich auch eintreffen. Das haben bisher kein Mythos und keine Religion geschafft.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
The use of programming tasks in interactive videos to increase learning effectiveness at MOOCs
Creators: name: Geier, Gerald
name: Weiß, Michael
name: Wachtler, Josef
name: Ebner, Martin
Publisher: name: Graz University of Technology
Year: 2024
Subjects: subject: Computer and information sciences
subject: FOS: Computer and information sciences
subject: Educational sciences
subject: FOS: Educational sciences

description: Presentation at ED-Media 2024 conference, Brussel
Ein winziger Krebs mit hohen Stiefeln
Creators: name: Müller, Thomas Volker
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Im Grunde ist die Beschreibung einer biologischen Art eine ernsthafte Aufgabe, die zum Beispiel in den „Rules of Zoological Nomenclature“ mehr oder weniger streng festgeschrieben ist. Laut dem leitenden Paläontologen Robert Fortey vom „Natural History Museum“ in London eine der „langweiligsten Bettlektüren“, die er sich „vorstellen kann“. Dessen ungeachtet beschreibt er in seinem Buch „Trilobiten!“ mit hintergründigem britischem Humor einige Kniffe, wie man in die vordergründige Tristesse der Taxonomie vergnügliche Epitheta einbringen kann – natürlich ohne Linnes’ Inspiration ins Lächerliche zu ziehen. Hinter manch einem gräzisierten oder lateinisierten Epitheton verbergen sich die Namen von Angebeteten, Liebschaften, Rockmusikern, Schauspielern oder Schriftstellern.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Palaeoneura markhoddlei Triapitsyn 2018
Creators: name: Huber, John T.
name: Read, Jennifer D.
name: Triapitsyn, Serguei V.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mymaridae
Palaeoneura
Palaeoneura markhoddlei

description: Palaeoneura markhoddlei Triapitsyn, 2018
Palaeoneura markhoddlei Triapitsyn, 2018b: 37. Holotype ♀ (UCRC). TL: USA, California, San Diego Co., Pauma Valley. Triapitsyn, 2018b: 37 (key).
Distribution. USA: CA.
description: Published as part of Huber, John T., Read, Jennifer D. & Triapitsyn, Serguei V., 2020, Illustrated key to genera and catalogue of Mymaridae (Hymenoptera) in America north of Mexico, pp. 1-411 in Zootaxa 4773 (3) on page 283, DOI: 10.11646/zootaxa.4773.1.1, http://zenodo.org/record/3821373
Additional file 3: Figure S1. of Exploring tomato Solanum pennellii introgression lines for residual biomass and enzymatic digestibility traits
Creators: name: G. Caruso
name: L. Gomez
name: F. Ferriello
name: A. Andolfi
name: C. Borgonuovo
name: A. Evidente
name: R. Simister
name: S. McQueen-Mason
name: D. Carputo
name: L. Frusciante
name: M. Ercolano
Publisher: name: Figshare
Year: 2016
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Plant Biology

description: Correlation between saccharification rate and crystalline cellulose and between saccharification rate and hemicellulose in 13 tomato introgression lines plus M82. (PDF 13Â kb)
Palaeoneura mymaripennis
Creators: name: Huber, John T.
name: Read, Jennifer D.
name: Triapitsyn, Serguei V.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mymaridae
Palaeoneura
Palaeoneura mymaripennis

description: Palaeoneura mymaripennis (Dozier, 1933)
Polynema mymaripennis Dozier, 1933: 96. Holotype ♀ (USNM). TL: USA, Delaware, Newark, University of Delaware Agricultural Experiment Station. Peck, 1951: 417 (catalogue); Peck, 1963: 47 (catalogue); Burks, 1979: 1033 (catalogue); Yoshimoto, 1990: 83 (list).
Palaeoneura mymaripennis: Triapitsyn & Aquino, 2010: 69 (description), 76 (key); Triapitsyn, 2018b: 37 (key).
Distribution. Canada. NB, ON. USA: DE, IL, NC.
description: Published as part of Huber, John T., Read, Jennifer D. & Triapitsyn, Serguei V., 2020, Illustrated key to genera and catalogue of Mymaridae (Hymenoptera) in America north of Mexico, pp. 1-411 in Zootaxa 4773 (3) on page 288, DOI: 10.11646/zootaxa.4773.1.1, http://zenodo.org/record/3821373
Angst vor Spinnen: Fürchten wir uns eigentlich vor Skorpionen?
Creators: name: Kunz, Kriton
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Furcht und Ekel spielen in der Evolution eine wichtige Rolle. Wer sich vor gefährlichen Tieren fürchtet oder vor verdorbenen Speisen ekelt, wird heikle Situationen eher überleben und kann seine Gene an die Nachkommen weitergeben. Wie aber ist zu erklären, dass Angst und Ekel vor Spinnen häufig sind, obwohl unsere Vorfahren im Lauf der Evolution kaum mit wirklich gefährlichen Vertretern dieser Tiergruppe konfrontiert waren?
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Palaeoneura saga
Creators: name: Huber, John T.
name: Read, Jennifer D.
name: Triapitsyn, Serguei V.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mymaridae
Palaeoneura
Palaeoneura saga

description: Palaeoneura saga (Girault, 1911)
Anagrus saga Girault, 1911 [96]: 296. Holotype ♀ (USNM). TL: USA, District of Columbia, Washington. Girault, 1911 [96]: 298 (key); Crosby & Leonard, 1914a: 182 (key); Thompson, 1958: 567 (host catalogue).
Polynema saga: Girault, 1929 [428]: 17 (key); Lawson, 1929: 130 (host, percent parasitism, distribution); Swezey, 1929: 291 (list, host) [A]; Harding, 1930: 18 (host, percent parasitism, larval movement, emergence); Zimmerman, 1948: 83 (host) [A]; Yoshimoto, 1990: 83 (list, generic transfer); Wiesenborn, 2002: 116 (parasitism rate); Wiesenborn, 2005: 656 (host, distribution); Lin et al., 2007: 45 (list) [A]; Luft Albarracin et al., 2009: 12 (list) [NT]; Luft Albarracin et al., 2017: 670 (host) [NT].
Barypolynema saga: Ogloblin, 1946: 285 (generic transfer); Peck, 1951: 416 (catalogue); Peck, 1963: 42 (catalogue); Burks, 1979: 1031 (catalogue).
Polynema (Tarphypolynema) saga: Ogloblin, 1960b: 79 (key, distribution) [AT]; De Santis, 1967: 112 (catalogue) [NT].
Polynema (Polynema) saga: Triapitsyn & Fidalgo, 2006: 60 (subgeneric placement).
Palaeoneura saga: Triapitsyn, 2018b: 37 (key), 41 (generic transfer, description, distribution).
Nearctic hosts. Cicadellidae: Opsius stactogalus Fieber.
Distribution. USA: AZ, CA, DC, KS, NV, UT.
description: Published as part of Huber, John T., Read, Jennifer D. & Triapitsyn, Serguei V., 2020, Illustrated key to genera and catalogue of Mymaridae (Hymenoptera) in America north of Mexico, pp. 1-411 in Zootaxa 4773 (3) on pages 288-289, DOI: 10.11646/zootaxa.4773.1.1, http://zenodo.org/record/3821373
Additional file 4: of Comparative analysis of Wnt expression identifies a highly conserved developmental transition in flatworms
Creators: name: Koziol, Uriel
name: Jarero, Francesca
name: Olson, Peter
name: Brehm, Klaus
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Alkaline phosphatase-based development of whole-mount in situ hybridization in H. microstoma : SFRPs and posterior Wnt components. Bars: 50Â Îźm. (PDF 5034 kb)
Rekordverdächtige Innervierung des Elefantenrüssels
Creators: name: Hille-Rehfeld, Annette
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Die großzügige Ausstattung des Elefantenrüssels mit sensorischen Nerven ist bemerkenswert. Ein Vergleich mit der Innervierung von Auge und Ohr wirft neues Licht auf die Bedeutung des Tastsinns.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Additional file 1: Table S1. of Non contiguous-finished genome sequence and description of Microbacterium gorillae sp. nov.
Creators: name: Hadjadj, Linda
name: Jaishriram Rathored
name: Keita, Mamadou
name: Michelle, Caroline
name: Levasseur, Anthony
name: Raoult, Didier
name: Pierre-Edouard Fournier
name: Jean-Marc Rolain
name: Bittar, Fadi
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Differential phenotypic characteristics between Microbacterium gorillae sp. nov. strain G3T and others Microbacterium strains. (DOCX 14Â kb)
Additional file 7: Figure S3. of Positive geotactic behaviors induced by geomagnetic field in Drosophila
Creators: name: Bae, Ji-Eun
name: Sunhoe Bang
name: Soohong Min
name: Sang-Hyup Lee
name: Soon-Hwan Kwon
name: Youngseok Lee
name: Lee, Yong-Ho
name: Jongkyeong Chung
name: Kwon-Seok Chae
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: CRY, PDF and Pyx pathways are required for the near-zero GMF-induced negative geotaxis. (A, C, E) Comparisons of the geotactic positioning of the CRY-, PDF- and Pyx-deficient flies rescued with their coding genes (cry-GAL4/UAS-cry;cry 01 , pdf-GAL4/UAS-pdf;pdf 01 and pyx-GAL4/UAS-pyx;pyx 3 ), respectively. Error bars: SEM. n.s., not significant. **, P
Umgang mit personenbezogenen Forschungsdaten: Praktisches Vorgehen
Creators: name: Richter, Thomas
Publisher: name: Zenodo
Year: 2024
Subjects: Forschungsdatenmanagement
DSGVO
Informierte Einwilligung
Anonymisierung
Datennutzungsvereinbarung
Personenbezogene Daten
HeFDI Data Week 2024

description: Rechtliche und ethische Anforderungen zum Umfang mit (sensiblen) personenbezogenen Forschungsdaten sind Forschenden bekannt, aber wie können diese in der Praxis umgesetzt werden? Der Vortrag (Teil der HeFDI Data Week 2024) gibt Hinweise zu informierter Einwilligung und Anonymisierungsstrategien für quantitative und qualitative Daten.

Werfen Sie auch einen Blick auf andere Veröffentlichungen der HeFDI Data Week 2024 oder die Veröffentlichungen anderer Veranstaltungen in der HeFDI-Zenodo-Community.
Additional file 1: Table S1. of Exploring tomato Solanum pennellii introgression lines for residual biomass and enzymatic digestibility traits
Creators: name: G. Caruso
name: L. Gomez
name: F. Ferriello
name: A. Andolfi
name: C. Borgonuovo
name: A. Evidente
name: R. Simister
name: S. McQueen-Mason
name: D. Carputo
name: L. Frusciante
name: M. Ercolano
Publisher: name: Figshare
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Plant Biology

description: Fruit yield and harvest index of 37 tomato introgression lines. Table S2. Residual biomass and leaf area of tomato introgression lines. (DOCX 113Â kb)
The Realienation of the Commons: Wikidata and the Ethics of “Free” Data
Creators: name: McDowell, Zachary
name: Vetter, MA
Publisher: name: University of Illinois at Chicago
Year: 2024
Subjects: classificationCode: 4701
subject: Communication and media studies
classificationCode: 3605
subject: Screen and digital media

description: Wikipedia’s founding in 2001, accompanied by the techno-optimism of Web 2.0 and the ambitious agenda for free knowledge, inspired countless volunteers to contribute. The success of the encyclopedia both inspired and provided evidence of the power of “wikinomics,” “crowd-sourcing,” and “commons-based peer production.” In many ways, Wikipedia, and its parent company Wikimedia, can be viewed as the standardbearers of Web 2.0’s early promises for a free and open Web. However, the introduction of Wikipedia’s sister project Wikidata and its movement away from “share alike” licensing has dramatically shifted the relationship between editors and complicated Wikimedia’s ethics as it relates to the digital commons. This article investigates concerns surrounding what we term the “re-alienation of the commons,” especially as it relates to Google and other search engine companies’ reliance on data emerging from free/libre and open-source (FOSS/FLOSS) Web movements of the late 20th and early 21st centuries. Taking a Marxist approach, this article explores the labor relationship of editors to Wikimedia projects and how this “realienation” threatens this relationship, as well as the future of the community.
Begrenzter Spielraum der Evolution – Mutationen im Genom weniger zufällig als gedacht
Creators: name: Staiger, Dorothee
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Lange wurde angenommen, dass Mutationen im Erbgut zufällig entstehen und die natürliche Selektion in den nachfolgenden Generationen Mutationen an einigen Stellen des Genoms toleriert, während sie Individuen mit Mutationen in essentiellen Genen ausmerzt. Eine aktuelle Studie in der Modellpflanze Arabidopsis thaliana zeigt, dass Gene, die funktionell wichtig sind, weniger häufig mutieren und dass dies mit epigenetischen Faktoren korreliert.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Additional file 2: of Comparative analysis of Wnt expression identifies a highly conserved developmental transition in flatworms
Creators: name: Koziol, Uriel
name: Jarero, Francesca
name: Olson, Peter
name: Brehm, Klaus
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Phylogeny of sine oculis-homeobox (SIX-HD) transcription factors. The homeodomain (HD) and SIX domains of SIX-HD proteins of H. sapiens, D. melanogaster, E. multilocularis, and H. microstoma were aligned together with published planarian SIX-HD proteins, and a phylogeny was estimated by Maximum Likelihood analysis (with a JTT model) using MEGA 5.2 [85]. Bootstrap support values from 1,000 replicates are indicated next to the nodes. Genbank accession codes are given for H. sapiens, D. melanogaster, and for the planarians S. mediterranea and G. tigrina; GeneDB accession codes are given for E. multilocularis and H. microstoma. Different groups of SIX-HD proteins are outlined, and the six3/6 genes of E. multilocularis and H. microstoma are indicated by arrows. (PDF 109 kb)
KBF wieder in Präsenz unterwegs für die Biologie
Creators: name: Hänsch, Robert
name: Palmetshofer, Alois
name: Roller, Carsten
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Am 10. Juni 2022 fand die jährliche Plenartagung der Konferenz Biologischer Fachbereiche (KBF, https://www.kbf.bio) in langersehnter Präsenz in Braunschweig statt. Im Rahmen der Konferenz wurde auch die Auszeichnung Science Hero an die Virologin Melanie Brinkmann verliehen, die als Professorin für Genetik an der TU Braunschweig forscht.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Additional file 9: Figure S5. of Positive geotactic behaviors induced by geomagnetic field in Drosophila
Creators: name: Bae, Ji-Eun
name: Sunhoe Bang
name: Soohong Min
name: Sang-Hyup Lee
name: Soon-Hwan Kwon
name: Youngseok Lee
name: Lee, Yong-Ho
name: Jongkyeong Chung
name: Kwon-Seok Chae
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: CRY and Pyx function in JO for the near-zero GMF-induced negative geotaxis. (A, C, E) Comparisons of the geotactic positioning of CRY-, Pyx-, and PDF-deficient flies in which the expression of CRY, Pyx, and PDF was genetically restored in JO using nan-GAL4, a JO-specific GAL4 driver. Error bars: SEM. n.s., not significant. *, P
Platystethynium Ogloblin 1946
Creators: name: Huber, John T.
name: Read, Jennifer D.
name: Triapitsyn, Serguei V.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mymaridae
Platystethynium

description: PLATYSTETHYNIUM (PLATYPATASSON Ogloblin, 1946), stat. rev.
(Figs 800 –811)
Platystethynium Ogloblin, 1946: 290. Type species: Platystethynium onomarchicidum Ogloblin, 1946, by original designation. Platypatasson Ogloblin, 1946: 293. Type species: Platypatasson fransseni Ogloblin, 1946, by original designation. Synonymy
by Donev & Huber, 2002: 118.
Diagnosis. Body length 435–655 μm. Head in lateral view longer than high (Figs 800–803), with face strongly projecting anteriorly and mouthparts in almost same plane as toruli (Fig. 804); vertex with conspicuous, long setae next to eye (Figs 802–804); funicle segments shorter than wide (Fig. 805); clava 2-segmented (Fig. 805); fore wing narrow and parallel-sided (Fig. 806); frenum longitudinally divided medially (Fig. 807).
Discussion. Cleruchus and Platystethynium (Platypatasson) belong to the Cleruchus group of genera, which consists of species with dorsoventrally flattened bodies, claval segments quadrate or shorter than wide and head in lateral view bluntly triangular, with face strongly projecting anteriorly so toruli well anterior to the mouthparts. This group could be treated as a subgroup within a larger Anagrus group of genera depending on which features are used to define the Anagrus group. Donev & Huber (2002) treated Platypatasson as a synonym of Platystethynium rather than of Cleruchus as proposed by Schauff (1984). The frenum is entire in Cleruchus but longitudinally divided in both the former genera. Similarities in head structure, as well as their hosts (Orthoptera), also suggest a closer relationship of Platypatasson to Platystethynium and perhaps Anagrus, Omyomymar, Schizophragma and Stethynium than to Cleruchus, which are parasitoids of Coleoptera. Here we give Platypatasson subgeneric status as Platystethynium (Platypatasson), stat. rev., because the of their different number of claval segments, just as was done for A. (Anaphes) and Anaphes (Patasson). Only the subgenus Platypatasson occurs in the Nearctic.
Nearctic hosts. Unknown. Extralimital hosts are Orthoptera: Tettigoniidae (Ogloblin 1946).
Important reference. Ogloblin (1959b).
description: Published as part of Huber, John T., Read, Jennifer D. & Triapitsyn, Serguei V., 2020, Illustrated key to genera and catalogue of Mymaridae (Hymenoptera) in America north of Mexico, pp. 1-411 in Zootaxa 4773 (3) on pages 289-292, DOI: 10.11646/zootaxa.4773.1.1, http://zenodo.org/record/3821373
The Master Biology Entry Programme gewinnt den Ars legendi-Fakultätenpreis Biologie
Creators: name: Elbing, Kerstin
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Dagmar Hann und Daniela Meilinger von der Fakultät für Biologie der Ludwig-Maximilians-Universität München erhalten den diesjährigen Ars legendi-Fakultätenpreis Mathematik und Naturwissenschaften in der Kategorie Biologie. Die Preisträgerinnen haben ein umfassendes modulares Einführungsprogramm für Einsteigerinnen und Einsteiger internationaler biowissenschaftlicher Masterstudiengängen entwickelt. Die Angebote des The Master Biology Entry Programme tragen dazu bei, die internationalen Studierenden, die in Hinblick auf Theorie und Praxis recht unterschiedliche Qualifikationen mitbringen, auf einen vergleichbaren Wissensstand zu bringen.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Können Förderprogramme schaden?
Creators: name: Endesfelder, Ulrike
name: Schmidt, Fabian
name: Dresler, Martin
name: Kretschmer, Robert
name: Buddeberg, Eva
Publisher: name: Biologie in unserer Zeit - BiuZ
Year: 2022

description: Die Einwerbung von Forschungsgeldern, Stipendien und Preisen ist ein wichtiger Bestandteil einer erfolgreichen wissenschaftlichen Karriere. Doch wann lohnt es sich, wie viel Zeit in welche Ausschreibung zu investieren? Gerade für Wissenschaftler/-innen am Anfang ihrer Karriere ist dies schwer zu beurteilen. Hier kommentieren Ulrike Endesfelder, Fabian Schmidt, Martin Dresler, Robert Kretschmer und Eva Buddeberg ihre aktuelle Veröffentlichung und erklären, warum manche Förderprogramme der Wissenschaft eher schaden als nützen.
description: Biologie in unserer Zeit - BiuZ, Bd. 52 Nr. 3 (2022): Fleischproduktion 2.0
Nano-graphene oxide particles induce inheritable anomalies through altered gene expressions involved in oocyte maturation
Creators: name: Krishnakumar, Sreelakshmi
name: Malavika, Raghunath Nair
name: Nair, Shantikumar V.
name: Menon, Deepthy
name: Paul-Prasanth, Bindhu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: The inheritable impact of exposure to graphene oxide nanoparticles (GO NPs) on vertebrate germline during critical windows of gamete development remain undetermined to date. Here, we analyzed the transgenerational effects of exposure to nano-graphene oxide particles (nGO) synthesized in house with lateral dimensions 300–600 nm and surface charge of −36.8 mV on different developmental stages of germ cells (GCs): (1) during GCs undergoing early development and differentiation, and (2) during GCs undergoing gametogenesis and maturation in adulthood. Biocompatibility analyses in Japanese medaka embryos showed lethality above 1 µg/ml and also an aberrant increase in germ cell count of both males and females at doses below the lethal dose. However, no lethality or anomalies were evident in adults up to 45 µg/ml. Long term exposure of embryos and adults for 21 days resulted in reduced fecundity. This effect was transmitted to subsequent generations, F1 and F2. Importantly, the inheritable effects of nGO in adults were pronounced at a high dose of 10 µg/ml, while 1 µg/ml showed no impact on the germline indicating lower doses used in this study to be safe. Further, expressions of selected genes that adversely affected oocyte maturation were enhanced in F1 and F2 individuals. Interestingly, the inheritance patterns differed corresponding to the stage at which the fish received the exposure.
Multifunctional pro-ligands as potential Alzheimer’s disease therapeutics
Creators: name: Scott, Lauren
Publisher: name: University of British Columbia
Year: 2009

description: Alzheimer’s disease is the most common form of dementia, affecting more than 24 million individuals worldwide. Although the exact causes of disease development and progression are unknown, the amyloid hypothesis links the observed pathologies of elevated metal ion levels (Cu²⁺, Fe³⁺, Zn²⁺), deposition of amyloid peptide in senile plaques, oxidative stress and neurodegeneration in a cohesive manner. As part of a possible intervention for this process, a series of multifunctional pyridinone pro-ligands were designed and synthesised. 3-Hydroxy-4-pyridinones display a high affinity for metal ions - particularly Fe³⁺ and Cu²⁺ - and are readily functionalised by variation of the N-substituent on the heterocyclic ring. The alpha-hydroxyketone functionality serves not only to bind metal ions, but as an antioxidant via phenolic hydrogen donation; in addition, these activities may be masked by glycosylation at the 3-hydroxy position. Seven pyridinone pro-ligands were synthesised, each containing a pyridinone moiety and a second aromatic ring. Five of these pro-ligands incorporate structural features of amyloid imaging agents: 2-methyl-3-hydroxy-1-(4-dimethylaminophenyl)-4(1H)-pyridinone (Hdapp), 2-methyl-3-hydroxy-1-(4-methylaminophenyl)-4(1H)-pyridinone (Hsapp), 1-(4-aminophenyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (Hzapp), 1-(6-benzothiazolyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (Hbt6p) and 1-(2-benzothiazolyl)-3-hydroxy-2-methyl-4(1H)-pyridinone (Hbt2p). The final two compounds, 3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinone (Hppp) and 1-benzyl-3-hydroxy-2-methyl-4(1H)-pyridinone (Hnbp), were synthesised and compared to probe the impact of linker length modification between the two aromatic rings. In addition to pro-ligand synthesis, their activities were assessed using a number of in vitro assays. Ability to interfere with metal ion-induced amyloid peptide aggregation in solution, antioxidant activity, cytotoxicity, coordination of Cu²⁺ and binding to amyloid fibrils were all assayed on this series. This was done as a preliminary screen to identify promising lead compounds for further development. The compounds displayed marked ability to resolubilise metal ion-aggregated amyloid-beta, excellent antioxidant activity comparable to that of alpha-tocopherol and acceptable cytotoxicity levels. Furthermore, the ligands coordinate Cu²⁺ in the bis, square planar, tetracoordinate fashion typical of 3-hydroxy-4-pyridinones, and their binding to amyloid-beta fibrils was found to be dependent on ring structure. This work incorporates the first examples of rationally-designed small-molecule Alzheimer’s therapeutics incorporating such multifunctionality, and it is expected that the combination will promote more effective Alzheimer’s intervention than current metal ion-binding therapeutics such as clioquinol and other 8-hydroxyquinoline derivatives in development.
Additional file 3: of Physiological mechanisms of dehydration tolerance contribute to the invasion potential of Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) relative to its less widely distributed congeners
Creators: name: Weldon, Christopher
name: Boardman, Leigh
name: Marlin, Danica
name: Terblanche, John
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Table S3. General linear model for the relationship between species, sex, temperature (Temp) and relative humidity (RH) on the dehydration tolerance of three Ceratitis species. Estimated body water (determined from initial body mass using the equations in Table S1) was included as a covariate. Significant effects (Pâ
Additional file 1: of Serious electronic games as behavioural change interventions in healthcare-associated infections and infection prevention and control: a scoping review of the literature and future directions
Creators: name: Castro-Sánchez, Enrique
name: Yiannis Kyratsis
name: Iwami, Michiyo
name: Rawson, Timothy
name: Holmes, Alison
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Search strings in five electronic databases and Google Scholar. Search strings in Ovid MEDILINE, Embase Classic + Embase, PsycINFO, Scopus, The Cochrane Library Database, and Google Scholar. (DOCX 43 kb)