cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A comprehensive collection of systems biology data characterizing the host response to viral infection
Creators: name: Gralinski, Lisa E.
name: Green, Richard R.
name: Pickett, Brett E.
name: Luna, Maria L.
name: Agnihothram, Sudhakar
name: Bolles, Meagen
name: Carter, Victoria
name: Ellis, Amy
name: Bankhead, Armand
name: Askovich, Peter S.
name: Kumar, Sanjeev
name: Heegel, Robert A.
name: Law, G. Lynn
name: Aevermann, Brian D.
name: Li, Chengjun
name: Jeng, Sophia
name: Li, Jiangning
name: Kaiser, Shari M.
name: Jacobs, Jon M.
name: Long, Casey
name: Chang, Jean
name: Fan, Shufang
name: Hatta, Masato
name: Diercks, Alan H.
name: Eisfeld, Amie J.
name: Dash, Pradyot
name: Josset, Laurence
name: Kelly, Sara
name: Clauss, Therese R.W.
name: Gritsenko, Marina A.
name: Klem, Edward B.
name: Ferris, Martin T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). By comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.
Resonant Faraday and Kerr effects due to in-gap states on the surface of a topological insulator
Creators: name: Wilson, Justin H.
name: Efimkin, Dmitry K.
name: Galitski, Victor M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: When Dirac electrons on the surface of a topological insulator are gapped, the resulting quantum anomalous Hall effect leads to universal magneto-optical Faraday and Kerr effects in the low frequency limit. However, at higher frequencies different excitations can leave their own fingerprints on the magneto-optics and can therefore be probed. In particular, we investigate the role of localized in-gap states---which inevitably appear in the presence of charged impurities---on these higher frequency magneto-optical effects. We have shown that these states resonantly contribute to the Hall conductivity and are magneto-optically active. These in-gap states lead to peculiar resonant signatures in the frequency dependence of the Faraday and Kerr angles, distinct in character to the contribution of in-gap excitonic states, and can be probed in ellipsometry measurements.
description: 10 pages, 10 figures, updated following the peer review process
Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies
Creators: name: Britton, Laura-Mae
name: Krajewski, Krzysztof
name: Rothbart, Scott B.
name: Strahl, Brian D.
name: Lin, Shu
name: Keogh, Michael-C
name: Garcia, Benjamin A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Antibodies specific for histone post-translational modifications (PTMs) have been central to our understanding of chromatin biology. Here, we describe an unexpected and novel property of histone H4 site-specific acetyl antibodies in that they prefer poly-acetylated histone substrates. By all current criteria, these antibodies have passed specificity standards. However, we find these site-specific histone antibodies preferentially recognize chromatin signatures containing two or more adjacent acetylated lysines. Significantly, we find that the poly-acetylated epitopes these antibodies prefer are evolutionarily conserved and are present at levels that compete for these antibodies over the intended individual acetylation sites. This alarming property of acetyl-specific antibodies has far-reaching implications for data interpretation and may present a challenge for the future study of acetylated histone and non-histone proteins.
Additional file 3 of Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing
Creators: name: Mansbart, Felix
name: Kienberger, Gerda
name: Sönnichsen, Andreas
name: Mann, Eva
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 3. Summary of characteristics of included studies.
The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
Creators: name: Kesimer, Mehmet
name: Xu, Qing
name: Lu, Jing
name: Tolun, Gökhan
name: Griffith, Jack D.
name: Li, Xiaoling
name: Sheehan, John K.
name: Zheng, Xunhai
name: Guo, Xiumei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: SIRT1, a NAD+-dependent protein deacetylase, is an important regulator in cellular stress response and energy metabolism. While the list of SIRT1 substrates is growing, how the activity of SIRT1 is regulated remains unclear. We have previously reported that SIRT1 is activated by phosphorylation at a conserved Thr522 residue in response to environmental stress. Here we demonstrate that phosphorylation of Thr522 activates SIRT1 through modulation of its oligomeric status. We provide evidence that nonphosphorylated SIRT1 protein is aggregation-prone in vitro and in cultured cells. Conversely, phosphorylated SIRT1 protein is largely in the monomeric state and more active. Our findings reveal a novel mechanism for environmental regulation of SIRT1 activity, which may have important implications in understanding the molecular mechanism of stress response, cell survival, and aging.
ОСОБЕННОСТИ ВЕДЕНИЯ БУХГАЛТЕРСКОГО УЧЕТА И АУДИТА ПРИ ПРОИЗВОДСТВЕ И РЕАЛИЗАЦИИ МЯСА ПТИЦЫ
Creators: name: Кот Е.М.
name: Стахеева Л.М.
name: Пильникова И.Ф.
name: Пильников Л.Н.
name: Судакова Е.А.
Publisher: name: Образование и право
Year: 2022
Subjects: бухгалтерский учет
анализ
аудит
реализация
производство
мясо птицы.

description: Птицеводство является одной из важнейших отраслей, которая обеспечивает население высококачественными диетическими продуктами питания – это мясо птицы и яйца. Результаты исследования показывают особенности ведения бухгалтерского учета и аудита при производстве и реализации мяса птицы, а также определяют некоторые особенности при проведении экономического анализа, характерные именно для данного вида деятельности. Компании в данной отрасли также могут применять различные формы налогообложения, но для эффективного ведения бизнеса всем им необходимо грамотное построение бухгалтерского учета, проведение анализа и проведение аудиторских проверок.
Interstellar ice analogs: band strengths of H$_2$O, CO$_2$, CH$_3$OH, and NH$_3$ in the far-infrared region
Creators: name: Giuliano, B. M.
name: Escribano, R. M.
name: Martín-Doménech, R.
name: Dartois, E.
name: Caro, G. M. Muñoz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We measure the band strengths in the far-infrared region of interstellar ice analogs of astrophysically relevant species, such as H$_2$O, CO$_2$, CH$_3$OH, and NH$_3$, deposited at low temperature (8-10 $\mathrm{K}$), followed by warm-up, to induce amorphous-crystalline phase transitions when relevant. The spectra of pure H$_2$O, NH$_3$, and CH$_3$OH ices have been measured in the near-, mid- and far-infrared spectroscopic regions using the Interstellar Astrochemistry Chamber (ISAC) ultra-high-vacuum setup. In addition, far-infrared spectra of NH$_3$ and CO$_2$ were measured using a different set-up equipped with a bolometer detector. Band strengths in the far-infrared region were estimated using the corresponding near- and mid-infrared values as a reference. We also performed theoretical calculations of the amorphous and crystalline structures of these molecules using solid state computational programs at density functional theory (DFT) level. Vibrational assignment and mode intensities for these ices were predicted. Infrared band strengths in the 25-500 $μ$m range have been determined for the considered ice samples by direct comparison in the near- and mid-infrared regions. Our values were compared to those we calculated from the literature complex index of refraction. We found differences of a factor of two between the two sets of values. The calculated far-infrared band strengths provide a benchmark for interpreting the observational data from future space telescope missions, allowing the estimation of the ice column densities.
description: Key words. astrochemistry -- methods: laboratory: solid state -- ISM: molecules -- techniques: spectroscopic -- infrared: ISM
Fine-grained domain counting and percolation analysis in 2D lattice systems with linked-lists
Creators: name: Sable, Hrushikesh
name: Gaur, Deepak
name: Angom, D.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We present a fine-grained approach to identify clusters and perform percolation analysis in a 2D lattice system. In our approach, we develop an algorithm based on the linked-list data structure whereby the members of a cluster are nodes of a path. This path is mapped to a linked-list. This approach facilitates unique cluster labeling in a lattice with a single scan. We use the algorithm to determine the critical exponent in the quench dynamics from the Mott insulator to the superfluid phase of bosons in 2D square optical lattices. The results obtained are consistent with the Kibble-Zurek mechanism. We also employ the algorithm to compute the correlation length using definitions based on percolation theory and use it to identify the quantum critical point of the Bose Glass to superfluid transition in the disordered 2D square optical lattices. In addition, we compute the critical exponent $ν$ which quantify the divergence of the correlation length $ξ$ across the phase transition and the fractal dimension of the hulls of the superfluid clusters.
description: 15 pages, 15 figures, Published in the October issue of Physical Review E (Vol. 108, No. 4)
High-Energy Scattering vs Static QCD Strings
Creators: name: Petrov, V. A.
name: Ryutin, R. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the shape of the interaction region of the elastically scattered protons stipulated by the high-energy Pomeron exchange which turns out to be very similar with the shape of the static string representing the confining QCD flux tube. This similarity disappears when we enter the LHC energy region, which corresponds to many-Pomeron exchanges. Reversing the argument we conjecture a modified relationship between the width and the length of the confining string at very large lengths.
description: 4 pages, 4 figures
Tomographic laser absorption spectroscopy using Tikhonov regularization
Creators: name: Guha, Avishek
name: Schoegl, Ingmar
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The application of tunable diode laser absorption spectroscopy (TDLAS) to flames with non-homogeneous temperature and concentration fields is an area where only few studies exist. Experimental work explores the performance of tomographic reconstructions of concentration and temperature profiles from wavelength-modulated TDLAS measurements within the plume of an axisymmetric McKenna burner. Water vapor transitions at 1391.67 nm and 1442.67 nm are probed using calibration free wavelength modulation spectroscopy with second harmonic detection (WMS-2f). A single collimated laser beam is swept parallel to the burner surface, where scans yield pairs of line-of-sight (LOS) data at multiple radial locations. Radial profiles of absorption data are reconstructed using Tikhonov regularized Abel inversion, which suppresses the amplification of experimental noise that is typically observed for reconstructions with high spatial resolution. Based on spectral data, temperatures and concentrations are calculated point-by-point. Here, a least-squares approach addresses difficulties due to modulation depths that cannot be universally optimized due to a non-uniform domain. Experimental results show successful reconstructions of temperature and concentration profiles based on two-transition, non-optimally modulated WMS-2f and Tikhonov regularized Abel inversion, and thus validate the technique as a viable diagnostic tool for flame measurements.
description: This paper was published in Applied Optics and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/AO.53.008095. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law
Additional file 4 of Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing
Creators: name: Mansbart, Felix
name: Kienberger, Gerda
name: Sönnichsen, Andreas
name: Mann, Eva
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 4. Summary of patient characteristics of included studies.
Additional file 1 of Seed priming to optimize germination in Arthrocnemum Moq.
Creators: name: Ramírez, Esteban
name: Chaâbene, Zayneb
name: Hernández-Apaolaza, Lourdes
name: Rekik, Mariem
name: Elleuch, Amine
name: de la Fuente, Vicenta
Publisher: name: figshare
Year: 2022
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1.
Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi
Creators: name: Mvalo, Tisungane
name: Emch, Michael
name: Escamilla, Veronica
name: Hoffman, Irving
name: Congdon, Seth
name: Juliano, Jonathan J.
name: Bowman, Natalie M.
name: Meshnick, Steven R.
name: Martinson, Francis
name: Patel, Jaymin C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Humoral immunity to Plasmodium falciparum circumsporozoite protein is partly mediated by a polymorphic NANP tetra-amino acid repeat. Antibody response to these repeats is the best correlate of protective immunity to the RTS,S malaria vaccine, but few descriptions of the natural variation of these repeats exist. Using capillary electrophoresis to determine the distribution of NANP repeat size polymorphisms among 98 isolates from Lilongwe, Malawi, we characterised the diversity of P. falciparum infection by several ecological indices. Infection by multiple distinct variants was common, and 20 distinct repeat sizes were identified. Diversity of P. falciparum appeared greater in children (18 variants) than adults (12 variants). There was evidence of genetic distance between different geographic regions by Nei's Standard Genetic Distance, suggesting parasite populations vary locally. We show that P. falciparum is very diverse with respect to NANP repeat length even on a local level and that diversity appears higher in children.
ОСОБЕННОСТИ ПРОФЕССИОНАЛЬНОГО РАЗВИТИЯ ГОСУДАРСТВЕННЫХ ГРАЖДАНСКИХ СЛУЖАЩИХ В УСЛОВИЯХ ЦИФРОВИЗАЦИИ
Creators: name: Чумаков Н.К.
Publisher: name: Образование и право
Year: 2022
Subjects: профессиональное развитие
государственные гражданские служащие
цифровизация
дистанционные технологии
самообразование.

description: Целью настоящего исследования является установление особенностей профессионального развития государственных гражданских служащих в условиях цифровизации, а также выявление путей совершенствования института государственной службы посредством получения новых компетенций государственными служащими. В рамках исследования проводится анализ возможности использования дистанционных технологий для цели профессионального развития государственных гражданских служащих. Помимо особенностей профессионального развития выявлены некоторые проблемы, предложены пути решения. По итогам представленного исследования сделаны ряд выводов, в том числе о необходимости взаимодействия государственных органов с научными и научно-исследовательскими институтами, определены пути взаимодействия.
Large-Scale Structure Observables in General Relativity
Creators: name: Jeong, Donghui
name: Schmidt, Fabian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We review recent studies that rigorously define several key observables of the large-scale structure of the Universe in a general relativistic context. Specifically, we consider i) redshift perturbation of cosmic clock events; ii) distortion of cosmic rulers, including weak lensing shear and magnification; iii) observed number density of tracers of the large-scale structure. We provide covariant and gauge-invariant expressions of these observables. Our expressions are given for a linearly perturbed flat Friedmann-Robertson-Walker metric including scalar, vector, and tensor metric perturbations. While we restrict ourselves to linear order in perturbation theory, the approach can be straightforwardly generalized to higher order.
description: 24 pages, 3 figures. A review article submitted to CQG focus issue "Relativistic Effects in Cosmology". arXiv admin note: substantial text overlap with arXiv:1204.3625, v2: correct one missing reference
Additional file 5 of Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing
Creators: name: Mansbart, Felix
name: Kienberger, Gerda
name: Sönnichsen, Andreas
name: Mann, Eva
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 5. Additional information on patient characteristics for each study used in the included meta-analyses.
Inhomogeneous viscous dark fluid coupled with dark matter in the FRW universe
Creators: name: Elizalde, E.
name: Obukhov, V. V.
name: Timoshkin, A. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A cosmological model with an inhomogeneous viscous dark fluid coupled with dark matter in a flat Friedman-Robertson-Walker universe is investigated. The influence of dark matter on the behavior of an inhomogeneous viscous fluid of this kind, responsible for cosmic acceleration and for the appearance of different types of singularities, is analyzed in detail. In particular, the critical points corresponding to the solutions of the background equations in a useful approximation are obtained explicitly.
description: 11 pages, 2 figures, to appear in MPLA
Oxygen promotes biofilm formation of Shewanella putrefaciens CN32 through a diguanylate cyclase and an adhesin
Creators: name: Wu, Chao
name: Yu, Han-Qing
name: Li, Wen-Wei
name: Yin, Hao
name: Tian, Li-Jiao
name: Han, Jun-Cheng
name: Song, Xiang-Ning
name: Zhao, Li-Ping
name: Cheng, Yuan-Yuan
name: Zhou, Xian-Xuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Although oxygen has been reported to regulate biofilm formation by several Shewanella species, the exact regulatory mechanism mostly remains unclear. Here, we identify a direct oxygen-sensing diguanylate cyclase (DosD) and reveal its regulatory role in biofilm formation by Shewanella putrefaciens CN32 under aerobic conditions. In vitro and in vivo analyses revealed that the activity of DosD culminates to synthesis of cyclic diguanylate (c-di-GMP) in the presence of oxygen. DosD regulates the transcription of bpfA operon which encodes seven proteins including a large repetitive adhesin BpfA and its cognate type I secretion system (TISS). Regulation of DosD in aerobic biofilms is heavily dependent on an adhesin BpfA and the TISS. This study offers an insight into the molecular mechanism of oxygen-stimulated biofilm formation by S. putrefaciens CN32.
Additional file 1 of Determinants of self-reported hypertension among women in South Africa: evidence from the population-based survey
Creators: name: Ntenda, Peter Austin Morton
name: El-Meidany, Walaa Mamdouh Reyad
name: Tiruneh, Fentanesh Nibret
name: Motsa, Mfundi President Sebenele
name: Nyirongo, Joyce
name: Chirwa, Gowokani Chijere
name: Kapachika, Arnold
name: Nkoka, Owen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1. Questionnaire.
Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo
Creators: name: Emch, Michael
name: Janko, Mark
name: Parobek, Christian M.
name: Meshnick, Steven R.
name: Juliano, Jonathan J.
name: Taylor, Steve M.
name: Tshefu, Antoinette K.
name: Udhayakumar, Venkatachalam
name: Antonia, Alejandro L.
name: Alam, Md Tauqeer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Understanding the spatial clustering of Plasmodium falciparum populations can assist efforts to contain drug-resistant parasites and maintain the efficacy of future drugs. We sequenced single nucleotide polymorphisms (SNPs) in the dihydropteroate synthase gene (dhps) associated with sulfadoxine resistance and 5 microsatellite loci flanking dhps in order to investigate the genetic backgrounds, genetic relatedness, and geographic clustering of falciparum parasites in the Democratic Republic of the Congo (DRC). Resistant haplotypes were clustered into subpopulations: one in the northeast DRC, and the other in the balance of the DRC. Network and clonal lineage analyses of the flanking microsatellites indicate that geographically-distinct mutant dhps haplotypes derive from separate lineages. The DRC is therefore a watershed for haplotypes associated with sulfadoxine resistance. Given the importance of central Africa as a corridor for the spread of antimalarial resistance, the identification of the mechanisms of this transit can inform future policies to contain drug-resistant parasite strains.
Counting pairs of saddle connections
Creators: name: Athreya, J. S.
name: Fairchild, S.
name: Masur, H.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 32G15, 52C23, 30F30, 28C10

description: We show that for almost every translation surface the number of pairs of saddle connections with bounded magnitude of the cross product has asymptotic growth like $c R^2$ where the constant $c$ depends only on the area and the connected component of the stratum. The proof techniques combine classical results for counting saddle connections with the crucial result that the Siegel--Veech transform is in $L^2$. In order to capture information about pairs of saddle connections, we consider pairs with bounded magnitude of the cross product since the set of such pairs can be approximated by a fibered set which is equivariant under geodesic flow. In the case of lattice surfaces, small bounded magnitude of the cross product is equivalent to counting parallel pairs of saddle connections, which also have a quadratic growth of $c R^2$ where $c$ depends in this case on the given lattice surface.
description: Accepted Version for Advances in Mathematics
Strata of rational space curves
Creators: name: Cox, David A.
name: Iarrobino, Anthony A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 14Q05, 13D40, 65D17

description: The mu-invariant mu = (μ_1,μ_2,μ_3) of a rational space curve gives important information about the curve. In this paper, we describe the structure of all parameterizations that have the same mu-type, what we call a mu-stratum, and as well the closure of strata. Many of our results are based on papers by the second author that appeared in the commutative algebra literature. We also present new results not in the earlier papers, including an explicit formula for the codimension of the locus of non-proper parametrizations within each mu-stratum and a decomposition of the smallest mu-stratum based on which two-dimensional rational normal scroll the curve lies on.
description: 28 pages; revised version reflects minor changes in final version of the paper
ОСОБЕННОСТИ ПУБЛИЧНО-ПРАВОВОГО МЕХАНИЗМАОБЕСПЕЧЕНИЯ БЕЗОПАСНОСТИ ЛИЧНОСТИ
Creators: name: Ломаченко Е.В.
Publisher: name: Образование и право
Year: 2022
Subjects: безопасность личности
публично-правовой механизм
административное судопроизводство
административный процесс
действующий закон
суд
публично-правовые правоотношения
административные правоотношения.

description: В статье обозначено, что в качестве особенности публично-правового механизма обеспечения безопасности личности можно отметить тот аспект, что роль главного субъекта в правообеспечительном механизме выполняет непосредственно государство, при тесном взаимодействии со всеми ветвей власти, но с учетом правовой сущности государственно-правового механизма, можно сделать вывод о том, что по своей сущности и своему предназначению ведущая роль по защите прав и свобод граждан отведена непосредственно судебным органам власти. Однако нельзя не заметить, что до настоящего времени система административных судов пока в России не создана, что противоречит конституционным основам российского государства и усложняет процесс реализации механизма защиты безопасности личности.
ОТДЕЛЬНЫЕ ВОПРОСЫ ПРАВОВОГО РЕГУЛИРОВАНИЯ ОБРАБОТКИ ПЕРСОНАЛЬНЫХ ДАННЫХ В МОБИЛЬНЫХ ПРИЛОЖЕНИЯХ
Creators: name: Чипигина П.А.
Publisher: name: Образование и право
Year: 2022
Subjects: IP-адрес
геолокация
информация
обработка
оператор
местоположение
мобильные приложения
персональные данные
пользовательское соглашение.

description: В статье исследуется вопросы правового регулирования обработки персональных данных на мобильных устройствах. Приводится изучение материалов судебной практики с анализом и выражением авторского мнения. Описаны пользовательские соглашения приложений «Локатор» и «Zenly», где проанализированы персональные данные, которые запрашивают приложения. Были рассмотрены и описаны те данные, которые они собирают. По итогам работы сделан вывод, что не любая обработка персональных данных соответствует их пользовательскому соглашению. На основании этого были выявлены неточности политики конфиденциальности данных приложений.
Elastic Gradient Descent, an Iterative Optimization Method Approximating the Solution Paths of the Elastic Net
Creators: name: Allerbo, Oskar
name: Jonasson, Johan
name: Jörnsten, Rebecka
Publisher: name: arXiv
Year: 2022
Subjects: subject: Methodology (stat.ME)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The elastic net combines lasso and ridge regression to fuse the sparsity property of lasso with the grouping property of ridge regression. The connections between ridge regression and gradient descent and between lasso and forward stagewise regression have previously been shown. Similar to how the elastic net generalizes lasso and ridge regression, we introduce elastic gradient descent, a generalization of gradient descent and forward stagewise regression. We theoretically analyze elastic gradient descent and compare it to the elastic net and forward stagewise regression. Parts of the analysis are based on elastic gradient flow, a piecewise analytical construction, obtained for elastic gradient descent with infinitesimal step size. We also compare elastic gradient descent to the elastic net on real and simulated data and show that it provides similar solution paths, but is several orders of magnitude faster. Compared to forward stagewise regression, elastic gradient descent selects a model that, although still sparse, provides considerably lower prediction and estimation errors.
Additional file 1 of Isophthalate:coenzyme A ligase initiates anaerobic degradation of xenobiotic isophthalate
Creators: name: Junghare, Madan
name: Frey, Jasmin
name: Naji, Khalid M.
name: Spiteller, Dieter
name: Vaaje-Kolstad, Gustav
name: Schink, Bernhard
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1.
VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer
Creators: name: Perez-Chanona, Ernesto
name: Tomkovich, Sarah
name: Jobin, Christian
name: Arthur, Janelle C.
name: Mühlbauer, Marcus
name: Sha, Wei
name: Fodor, Anthony A.
name: Uronis, Joshua M.
name: Gharaibeh, Raad Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Although probiotics have shown success in preventing the development of experimental colitis-associated colorectal cancer (CRC), beneficial effects of interventional treatment are relatively unknown. Here we show that interventional treatment with VSL#3 probiotic alters the luminal and mucosally-adherent microbiota, but does not protect against inflammation or tumorigenesis in the azoxymethane (AOM)/Il10−/− mouse model of colitis-associated CRC. VSL#3 (109 CFU/animal/day) significantly enhanced tumor penetrance, multiplicity, histologic dysplasia scores, and adenocarcinoma invasion relative to VSL#3-untreated mice. Illumina 16S sequencing demonstrated that VSL#3 significantly decreased (16-fold) the abundance of a bacterial taxon assigned to genus Clostridium in the mucosally-adherent microbiota. Mediation analysis by linear models suggested that this taxon was a contributing factor to increased tumorigenesis in VSL#3-fed mice. We conclude that VSL#3 interventional therapy can alter microbial community composition and enhance tumorigenesis in the AOM/Il10−/− model.
The Roots and Links in a Class of $M$-Matrices
Creators: name: Zhang, Xiao-Dong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 15B48

description: In this paper, we discuss exiting roots of sub-kernel transient matrices $P$ associated with a class of $M-$ matrices which are related to generalized ultrametric matrices. Then the results are used to describe completely all links of the class of matrices in terms of structure of the supporting tree.
description: 11 pages, 1 figure
Additional file 1 of Teachers as multipliers of knowledge about schistosomiasis: a possible approach for health education programmes
Creators: name: Murta, Felipe Leão Gomes
name: Massara, Cristiano Lara
name: Rodrigues, Maria Gabriela
name: Beck, Lilian Christina Nóbrega Holsbach
name: Favre, Tereza Cristina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Content addressed, activities conducted and format of classes held with the teachers in the two training courses. https://doi.org/10.6084/m9.figshare.19990871 .
A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates
Creators: name: Ming, Xin
name: Chen, Meimei
name: Kong, Yi
name: Ye, Xiaohui
name: Su, Wen
name: Wang, Ying
name: Chen, Yahui
name: Su, Xingli
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Snake venom is a natural substance that contains numerous bioactive proteins and peptides, nearly all of which have been identified over the last several decades. In this study, we subjected snake venom to enzymatic hydrolysis to identify previously unreported bioactive peptides. The novel peptide ACH-11 with the sequence LTFPRIVFVLG was identified with both FXa inhibition and anti-platelet aggregation activities. ACH-11 inhibited the catalytic function of FXa towards its substrate S-2222 via a mixed model with a Ki value of 9.02 μM and inhibited platelet aggregation induced by ADP and U46619 in a dose-dependent manner. Furthermore, ACH-11 exhibited potent antithrombotic activity in vivo. It reduced paralysis and death in an acute pulmonary thrombosis model by 90% and attenuated thrombosis weight in an arterio-venous shunt thrombosis model by 57.91%, both at a dose of 3 mg/kg. Additionally, a tail cutting bleeding time assay revealed that ACH-11 did not prolong bleeding time in mice at a dose of 3 mg/kg. Together, our results reveal that ACH-11 is a novel antithrombotic peptide exhibiting both FXa inhibition and anti-platelet aggregation activities, with a low bleeding risk. We believe that it could be a candidate or lead compound for new antithrombotic drug development.
Ni-based nanoalloys: Towards thermally stable highly magnetic materials
Creators: name: Palagin, Dennis
name: Doye, Jonathan P. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Molecular dynamics simulations and density functional theory calculations have been used to demonstrate the possibility of preserving high spin states of the magnetic cores within Ni-based core-shell bimetallic nanoalloys over a wide range of temperatures. We show that, unlike the case of Ni-Al clusters, Ni-Ag clusters preserve high spin states (up to 8 $μ_{\mathrm{B}}$ in case of Ni$_{13}$Ag$_{32}$ cluster) due to small hybridization between the electronic levels of two species. Intriguingly, such clusters are also able to maintain geometrical and electronic integrity of their cores at temperatures up to 1000 K (e.g. for Ni$_{7}$Ag$_{27}$ cluster). Furthermore, we also show the possibility of creating ordered arrays of such magnetic clusters on a suitable support by soft-landing pre-formed clusters on the surface, without introducing much disturbance in geometrical and electronic structure of the cluster. We illustrate this approach with the example of Ni$_{13}$Ag$_{38}$ clusters adsorbed on the Si(111)-(7$\times$7) surface, which, having two distinctive halves to the unit cell, acts as a selective template for cluster deposition.
description: 9 pages, 10 figures
Overlooked Implications of the Reconstruction Loss for VAE Disentanglement
Creators: name: Michlo, Nathan
name: Klein, Richard
name: James, Steven
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences
subject: I.2; I.2.6; I.4.10

description: Learning disentangled representations with variational autoencoders (VAEs) is often attributed to the regularisation component of the loss. In this work, we highlight the interaction between data and the reconstruction term of the loss as the main contributor to disentanglement in VAEs. We show that standard benchmark datasets have unintended correlations between their subjective ground-truth factors and perceived axes in the data according to typical VAE reconstruction losses. Our work exploits this relationship to provide a theory for what constitutes an adversarial dataset under a given reconstruction loss. We verify this by constructing an example dataset that prevents disentanglement in state-of-the-art frameworks while maintaining human-intuitive ground-truth factors. Finally, we re-enable disentanglement by designing an example reconstruction loss that is once again able to perceive the ground-truth factors. Our findings demonstrate the subjective nature of disentanglement and the importance of considering the interaction between the ground-truth factors, data and notably, the reconstruction loss, which is under-recognised in the literature.
description: 13 pages, 12 figures, 4 tables
Additional file 2 of Isophthalate:coenzyme A ligase initiates anaerobic degradation of xenobiotic isophthalate
Creators: name: Junghare, Madan
name: Frey, Jasmin
name: Naji, Khalid M.
name: Spiteller, Dieter
name: Vaaje-Kolstad, Gustav
name: Schink, Bernhard
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 2:. Supplementary Materials
Accurate Inference of Local Phased Ancestry of Modern Admixed Populations
Creators: name: Zhang, Kui
name: Li, Wenzhi
name: Xu, Wei
name: Ma, Yamin
name: Song, Qing
name: Wong, Jian-Syuan
name: Zhao, Jian
name: Li, Yun
name: Fu, Guoxing
name: Kittles, Rick A.
name: Ma, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Population stratification is a growing concern in genetic-association studies. Averaged ancestry at the genome level (global ancestry) is insufficient for detecting the population substructures and correcting population stratifications in association studies. Local and phase stratification are needed for human genetic studies, but current technologies cannot be applied on the entire genome data due to various technical caveats. Here we developed a novel approach (aMAP, ancestry of Modern Admixed Populations) for inferring local phased ancestry. It took about 3 seconds on a desktop computer to finish a local ancestry analysis for each human genome with 1.4-million SNPs. This method also exhibits the scalability to larger datasets with respect to the number of SNPs, the number of samples, and the size of reference panels. It can detect the lack of the proxy of reference panels. The accuracy was 99.4%. The aMAP software has a capacity for analyzing 6-way admixed individuals. As the biomedical community continues to expand its efforts to increase the representation of diverse populations, and as the number of large whole-genome sequence datasets continues to grow rapidly, there is an increasing demand on rapid and accurate local ancestry analysis in genetics, pharmacogenomics, population genetics, and clinical diagnosis.
Adeno-Associated Viral Vectors Show Serotype Specific Transduction of Equine Joint Tissue Explants and Cultured Monolayers
Creators: name: Hemphill, Daniel D.
name: Samulski, R. Jude
name: Goodrich, Laurie R.
name: McIlwraith, C. Wayne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Adeno-associated virus (AAV) receptors range from heparan sulfate proteoglycan to sialic acid moieties present on cell surfaces. Abundance of the glycan profiles is greatly influenced by animal species, cell type, and culture conditions. The objective of this study was to determine whether AAV serotypes' transduction efficiencies specifically in the equine monolayer culture model are an accurate representation of transduction efficiencies in tissue explants, a model more closely related to in vivo transduction. It was found that AAV 2 and 2.5 transduced cells more efficiently in explants than in monolayers. Through experiments involving assessing enzyme degradation of cell surface proteoglycans, this change could not be attributed to differences in the extra cellular matrix (ECM), but a similar change in AAV 5 transduction efficiency could be readily explained by differences in cell surface sialylated glycan. Unexpectedly it was found that in a small but diverse sample of horses evidence for serum neutralizing antibodies was only found to AAV 5. This suggests a unique relationship between this capsid and the equine host or an unresolved relationship between similar bovine AAV and the AAV 5 capsid immune response.
ОТДЕЛЬНЫЕ ПРОБЛЕМЫ ЗАЩИТЫ СУБЪЕКТИВНЫХ ГРАЖДАНСКИХ ПРАВ
Creators: name: Коваль В.Н.
name: Путренко А.Н.
name: Волконская С.А.
Publisher: name: Образование и право
Year: 2022
Subjects: защита права
субъективное гражданское право
субъективное гражданское право на защиту
способы защиты гражданских прав
средства защиты субъективных гражданских прав
формы защиты
механизм осуществления и защиты гражданских прав.

description: В статье рассматриваются отдельные проблемы защиты субъективных гражданских прав как с точки зрения российской гражданско-правовой и гражданско-процессуальной доктрины, действующего законодательства, так и с учетом наличия проблем в правоприменительной практике. Отмечаются такие проблемы в данной сфере, как: отсутствие понятийного единообразия в теории защиты права; отсутствие единого методологического подхода к изучению механизмов осуществления и защиты прав; восприятие правоприменителем одних и тех же категорий защиты в различных значениях, влекущее неоднозначность правоприменительных актов; отсутствие должной систематизации средств защиты гражданских прав и др. В статье обосновывается целесообразность внесения изменений в ГК РФ в части определения в нем категорий «способы защиты гражданских прав» и «средства защиты гражданских прав».
Characterization of a novel N-acetylneuraminic acid lyase favoring industrial N-acetylneuraminic acid synthesis process
Creators: name: Ouyang, Pingkai
name: Song, Tianshun
name: Feng, Jinmei
name: Zhang, Dalu
name: Sun, Wujin
name: Ji, Wenyan
name: Xie, Jingjing
name: Gu, Zhen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: N-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3) is a Class I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N-acetyl-D-mannosamine (ManNAc). Due to the equilibrium favoring Neu5Ac cleavage, the enzyme catalyzes the rate-limiting step of two biocatalytic reactions producing Neu5Ac in industry. We report the biochemical characterization of a novel NAL from a “GRAS” (General recognized as safe) strain C. glutamicum ATCC 13032 (CgNal). Compared to all previously reported NALs, CgNal exhibited the lowest kcat/Km value for Neu5Ac and highest kcat/Km values for ManNAc and pyruvate, which makes CgNal favor Neu5Ac synthesis the most. The recombinant CgNal reached the highest expression level (480 mg/L culture), and the highest reported yield of Neu5Ac was achieved (194 g/L, 0.63 M). All these unique properties make CgNal a promising biocatalyst for industrial Neu5Ac biosynthesis. Additionally, although showing the best Neu5Ac synthesis activity among the NAL family, CgNal is more related to dihydrodipicolinate synthase (DHDPS) by phylogenetic analysis. The activities of CgNal towards both NAL's and DHDPS' substrates are fairly high, which indicates CgNal a bi-functional enzyme. The sequence analysis suggests that CgNal might have adopted a unique set of residues for substrates recognition.
Additional file 2 of Teachers as multipliers of knowledge about schistosomiasis: a possible approach for health education programmes
Creators: name: Murta, Felipe Leão Gomes
name: Massara, Cristiano Lara
name: Rodrigues, Maria Gabriela
name: Beck, Lilian Christina Nóbrega Holsbach
name: Favre, Tereza Cristina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Semi-structured interview guide. https://doi.org/10.6084/m9.figshare.19990880.v1 .