Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison
Creators: name: Suramya Waidyanatha
name: Black, Sherry R.
name: Purvi R. Patel
name: Watson, Scott L.
name: Snyder, Rodney W.
name: Sutherland, Vicki
name: Stanko, Jason
name: Fennell, Timothy R.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: Ecology
subject: Marine Biology
subject: 60506 Virology
subject: Computational Biology

description: Triclocarban is a residue-producing antibacterial agent used in a variety of consumer products. These studies investigated the disposition and metabolism of [<sup>14</sup>C]triclocarban.In male rats following a single gavage administration of 50, 150, and 500 mg/kg, excretion was primarily via feces (feces, 85–86%; urine, 3–6%) with no apparent dose-related effect. In male rats, 29% of the administered dose was excreted in bile suggesting some of the fecal excretion is from the absorbed dose which was excreted to the intestine via bile.The tissue retention of radioactivity was low in male rats (24 h, 3.9%; 72 h, 0.1%).Disposition pattern following gavage administration of 50 mg/kg in female rats and male and female mice were similar to male rats.Plasma elimination half-life of triclocarban in rats following gavage administration was shorter (∼2 h) compared to that based on total radioactivity (≥9 h) which included all products of triclocarban.Absorption following a single dermal application of 1.5 or 3% was low (≤3%) in rodents.Hydroxylated and conjugated metabolites of triclocarban predominated in bile.In hepatocytes, clearance of triclocarban in mouse and human was similar and was faster than in rat. Triclocarban is a residue-producing antibacterial agent used in a variety of consumer products. These studies investigated the disposition and metabolism of [<sup>14</sup>C]triclocarban. In male rats following a single gavage administration of 50, 150, and 500 mg/kg, excretion was primarily via feces (feces, 85–86%; urine, 3–6%) with no apparent dose-related effect. In male rats, 29% of the administered dose was excreted in bile suggesting some of the fecal excretion is from the absorbed dose which was excreted to the intestine via bile. The tissue retention of radioactivity was low in male rats (24 h, 3.9%; 72 h, 0.1%). Disposition pattern following gavage administration of 50 mg/kg in female rats and male and female mice were similar to male rats. Plasma elimination half-life of triclocarban in rats following gavage administration was shorter (∼2 h) compared to that based on total radioactivity (≥9 h) which included all products of triclocarban. Absorption following a single dermal application of 1.5 or 3% was low (≤3%) in rodents. Hydroxylated and conjugated metabolites of triclocarban predominated in bile. In hepatocytes, clearance of triclocarban in mouse and human was similar and was faster than in rat.