The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm
Creators: name: McQuiston, Susan
name: Dessureau, Brian
name: Peters, Nancy
name: Lenski, Madeleine
name: Venuti, Lauren
name: Jensen, Elizabeth T.
name: Martin, Ryan
name: Rollins, Julie
name: Allred, Elizabeth N.
name: Prendergast, Barbara
name: Asgarian, Aimee
name: Frazier, Jean
name: Douglass, Laurie
name: Sadhwani, Anjali
name: Damon-Minow, Jill
name: Allred, Debbie
name: Singh, Rachana
name: Wiggins, Suzanne
name: Kring, Beth
name: Scott, Megan
name: van der Burg, Jelske W.
name: Wereszczak, Janice
name: Ansusinha, Emily
name: O'Shea, Thomas M.
name: Bernhardt, Janice
name: Tsatsanis, Kathy
name: DeRidder, Jennifer
name: Coster, Taryn
name: Dieterich, Susan
name: Perrin, Ellen
name: Benjamin, Jennifer
name: Bearrs, Karen
name: Foley, Ann
name: Shah, Bhavesh
name: Walkowiak, Jenifer
name: Meyer, Echo
name: Joseph, Robert M.
name: Romano, Elaine
name: Wilson, Rachel
name: McGhee, Kirsten
name: Wood, Molly
name: Waldrep, Ellen
name: Neger, Emily
name: Leviton, Alan
name: Klarr, Judith
name: Ehrenkranz, Richard
name: Engelke, Stephen C.
name: Chawarska, Katarzyna
name: McKeeman, Joni
name: Stainback, Gary
name: Darden-Saad, Nancy
name: Heeren, Tim
name: Friedman, Jackie
name: Mattern, Kathryn
name: Warner, Diane
name: Henson, Brandi
name: Kuban, Karl C.K.
name: Rathbun, Julie
name: Weiland, Deborah
name: Nota, Sarah
name: Burdo-Hartman, Wendy
name: Msall, Michael
name: Klein, Deborah
name: Hunter, Scott
name: Vogt, Kelly
name: Powers, Beth
name: Kim, Sophy
name: Barron, Susan
name: Ramoskaite, Rugile
name: Crumb, Teri
name: Ware, Janice
name: Brown, Patricia
name: Pastyrnak, Steve
name: Washington, Krissy
name: Hounshell, Gail
name: O'Shea, T. Michael
name: Lee, Patricia
name: Smith, Anne
name: Lloyd, Megan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: OBJECTIVE: To assess the association between maternal prepregnancy body mass index and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm.

STUDY DESIGN: Study participants were 535 ten-year-old children enrolled previously in the prospective multicenter Extremely Low Gestational Age Newborns cohort study who were products of singleton pregnancies. Soon after delivery, mothers provided information about prepregnancy weight. Prepregnancy body mass index and adequacy of weight gain were characterized based on this information. Children underwent a neurocognitive evaluation at 10 years of age.

RESULTS: Maternal prepregnancy obesity was associated with increased odds of a lower score for Differential Ability Scales-II Verbal IQ, for Developmental Neuropsychological Assessment-II measures of processing speed and visual fine motor control, and for Wechsler Individual Achievement Test-III Spelling. Children born to mothers who gained an excessive amount of weight were at increased odds of a low score on the Oral and Written Language Scales Oral Expression assessment. Conversely, children whose mother did not gain an adequate amount of weight were at increased odds of a lower score on the Oral and Written Language Scales Oral Expression and Wechsler Individual Achievement Test-III Word Reading assessments.

CONCLUSION: In this cohort of infants born extremely preterm, maternal obesity was associated with poorer performance on some assessments of neurocognitive function. Our findings are consistent with the observational and experimental literature and suggest that opportunities may exist to mitigate risk through education and behavioral intervention before pregnancy.