cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
FRONTSH1P_D3.5 Ecodesign case studies CSS1 - Framework for the Ecodesign activities
Creators: name: LNEG
Publisher: name: FRONTSH1P Project
Year: 2023

description: The aim of the Ecodesign approach within the FRONTSH1P project is to identify measures that have the strongest leverage for an environmentally oriented improvement of a product or value chain, which will:

• Provide guidelines for LCA and S-LCA, integrating a circular design perspective and needs; • Allow the identification of the circular design strategies, based on a tool developed in a previous project on circular design (the KATCH_e CE Designer tool- www.katche.eu) with more potential for the identified products; • Lead to the identification of improvement opportunities and measures for the strategies – illustrated with examples and case studies.

Additionally, the Ecodesign activity within FRONTSH1P includes structuring the information, data, methodologies, and guidelines to support the development of the tool within WP7.

In view of this, the content of the present document is in accordance with the description of the activity in the Grant Agreement and goes beyond the designation of the respective deliverable. The methodology used to implement Ecodesign in FRONTSH1P relies on the analysis of value chains involved in the CSSs, the mapping of environmental, social and economic value losses and the identification of opportunities to capture/recover that value, through the application of Ecodesign strategies and criteria. Five steps are undertaken, using specific templates that were  created for each CSS using the ‘Mural’ collaborative platform:• step 1 - the identification of all actors in the CSS’s value chain,• step 2 - the identification of the interactions between them,• step 3 - the identification of value losses (environmental, economic and social),• step 4 - the identification of Ecodesign opportunities based on the losses from step 3,• step 5 - development of guidelines for improvement of the product, service, process and business model.

The resources developed to support the methodology are also presented in this document:• Indicators and data needs,• Checklists for value losses and opportunities identification,• Circular design strategies and criteria,• Examples and case studies. The method is applied and tested to the CSS that is under LNEG’s responsibility (CSS3), given that the Ecodesign team had easier access to more in-depth data and information from coworkers; this activity will be replicated in the other CSSs.
Additional file 1 of Risk factor analysis and optimal cutoff value selection of PSAD for diagnosing clinically significant prostate cancer in patients with negative mpMRI: results from a high-volume center in Southeast China
Creators: name: Lin, Shen
name: Jiang, Wubin
name: Ding, Jiafeng
name: Hao, Sida
name: Chen, Hong
name: Xie, Liping
name: Zheng, Xiangyi
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
Modeling and predicting IBNR reserve: extended chain ladder and heteroscedastic regression analysis
Creators: name: Costa, Leonardo
name: Pizzinga, Adrian
name: Atherino, Rodrigo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This work deals with two methodologies for predicting incurred but not reported (IBNR) actuarial reserves. The first is the traditional chain ladder, which is extended for dealing with the calendar year IBNR reserve. The second is based on heteroscedastic regression models suitable to deal with the tail effect of the runoff triangle – and to forecast calendar year IBNR reserves as well. Theoretical results regarding closed expressions for IBNR predictors and mean squared errors are established – for the case of the second methodology, a Monte Carlo study is designed and implemented for accessing finite sample performances of feasible mean squared error formulae. Finally, the methods are implemented with two real data sets. The main conclusions: (i) considering tail effects does not imply theoretical and/or computational problems; and (ii) both methodologies are interesting to design softwares for IBNR reserve prediction.
Additional file 3 of Applying systems approaches to stakeholder and community engagement and knowledge mobilisation in youth mental health system modelling
Creators: name: Freebairn, Louise
name: Song, Yun Ju Christine
name: Occhipinti, Jo-An
name: Huntley, Samantha
name: Dudgeon, Pat
name: Robotham, Julie
name: Lee, Grace Yeeun
name: Hockey, Samuel
name: Gallop, Geoff
name: Hickie, Ian B.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Appendix S3. Site visit 3 agenda.
On Onsager's type conjecture for the inviscid Boussinesq equations
Creators: name: Miao, Changxing
name: Nie, Yao
name: Ye, Weikui
Publisher: name: arXiv
Year: 2024
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we investigate the Cauchy problem for the three dimensional inviscid Boussinesq system in the periodic setting. For $1\le p\le \infty$, we show that the threshold regularity exponent for $L^p$-norm conservation of temperature of this system is $1/3$, consistent with Onsager exponent. More precisely, for $1\le p\le\infty$, every weak solution $(v,θ)\in C_tC^β_x$ to the inviscid Boussinesq equations satisfies that $\|θ(t)\|_{L^p(\mathbb{T}^3)}=\|θ_0\|_{L^p(\mathbb{T}^3)}$ if $β>\frac{1}{3}$, while if $β<\frac{1}{3}$, there exist infinitely many weak solutions $(v,θ)\in C_tC^β_x$ such that the $L^p$-norm of temperature is not conserved. As a byproduct, we are able to construct many weak solutions in $C_tC^β_x$ for $β<\frac{1}{3}$ displaying wild behavior, such as fast kinetic energy dissipation and high oscillation of velocity. Moreover, we also show that if a weak solution $(v, θ)$ of this system has at least one interval of regularity, then this weak solution $(v,θ)$ is not unique in $C_tC^β_x$ for $β<\frac{1}{3}$.
title: Χαρισματικοί - ταλαντούχοι μαθητές και ελληνικό εκπαιδευτικό σύστημα
title: Gifted and talented students and the Greek education system
titleType: AlternativeTitle
Creators: name: Ανέστη, Ελένη
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Χαρισματικοί μαθητές
Ταλαντούχοι μαθητές
Ελληνικό εκπαιδευτικό σύστημα

description: Εισαγωγή: Η συγκεκριμένη βιβλιογραφική μελέτη επικεντρώνεται στην ιδέα ότι η δημιουργία ενός πραγματικά δημοκρατικού ελληνικού σχολείου απαιτεί την αναγνώριση και αντιμετώπιση των ξεχωριστών εκπαιδευτικών αναγκών των χαρισματικών παιδιών. Ο στόχος δεν είναι να επιβαρυνθούν οι εκπαιδευτικοί με νέους ρόλους, αλλά να εμπλουτιστούν με νέες παιδαγωγικές δεξιότητες και τη δυνατότητα αυτομόρφωσης σε θέματα που αφορούν την εκπαίδευση των χαρισματικών παιδιών. Σκοπός: Η προσέγγιση αυτή αντικατοπτρίζει τη σημασία της κοινωνικής δικαιοσύνης στο εκπαιδευτικό σύστημα, που πρέπει να επικεντρώνεται στη διαφοροποίηση και στην ευαισθητοποίηση σε όλα τα παιδιά, συμπεριλαμβανομένων και εκείνων με χαρισματικές ικανότητες. Αντί να θεωρούνται οι χαρισματικοί μαθητές ως επιπρόσθετη πρόκληση, η έρευνα υπογραμμίζει ότι οι εκπαιδευτικοί μπορούν να εμπλουτίσουν τις πρακτικές τους για την ευνοϊκή ανάπτυξη όλων των μαθητών μέσω της προσαρμογής της διδασκαλίας σε διαφορετικές ανάγκες και ικανότητες. Συνολικά, η έρευνα αυτή προτείνει πρακτικές προσεγγίσεις που ανταποκρίνονται στην ανάγκη για πιο ανοικτό, ευέλικτο και προσαρμοσμένο εκπαιδευτικό περιβάλλον που αντιμετωπίζει και ενισχύει τις χαρισματικές ικανότητες των παιδιών. Μέθοδος: Η επισκόπηση του πεδίου γίνεται μέσω της ανάλυσης δημοσιεύσεων από επιστημονικά συνέδρια και αξιόπιστα επιστημονικά περιοδικά της ελληνικής βιβλιογραφίας, ακολουθώντας ένα αυστηρό πρωτόκολλο. Συγκεκριμένα, κατά το πρωτόκολλο αυτό, είναι υποχρεωτικό να καθοριστούν με σαφήνεια ο ερευνητικός στόχος, το ερευνητικό ερώτημα και τα κριτήρια με βάση τα οποία θα επιλεγούν οι βιβλιογραφικές πηγές (Munn, και συν., 2022). Αυτή η προσέγγιση εγγυάται τη σαφήνεια και τη συνέπεια στην αξιολόγηση της βιβλιογραφίας, καθιστώντας τη διαδικασία διαφανή και επαναληπτική. Αξίζει να αναφερθεί, πως η έρευνα στηρίζεται σε πληροφορίες που προέρχονται από αναγνωρισμένες πηγές, όπως επιστημονικά συνέδρια και περιοδικά, εγγυώμενη την αξιοπιστία των δεδομένων. Αποτελέσματα: Οι ερευνητικές μελέτες αναδεικνύουν τη σημασία της αποτελεσματικής αναγνώρισης και διαχείρισης της χαρισματικότητας στην εκπαίδευση, επισημαίνοντας προκλήσεις και αδυναμίες. Προτείνουν την εφαρμογή διαφοροποιημένης διδασκαλίας, ενισχύοντας τη συμμετοχή γονέων και εκπαιδευτικών, ενώ υπογραμμίζουν την ανάγκη για σαφείς νομοθετικές ρυθμίσεις. Τα αποτελέσματα αυτά ενισχύουν την κατανόηση της χαρισματικότητας στον εκπαιδευτικό χώρο και προτρέπουν σε βελτιώσεις για την υποστήριξη χαρισματικών μαθητών. Λέξεις κλειδιά: Χαρισματικοί, Ταλαντούχοι μαθητές, Ελληνικό εκπαιδευτικό σύστημα
Additional file 1 of The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer’s disease
Creators: name: Wang, Yi-Ting
name: Ashton, Nicholas J.
name: Servaes, Stijn
name: Nilsson, Johanna
name: Woo, Marcel S.
name: Pascoal, Tharick A.
name: Tissot, Cécile
name: Rahmouni, Nesrine
name: Therriault, Joseph
name: Lussier, Firoza
name: Chamoun, Mira
name: Gauthier, Serge
name: Brinkmalm, Ann
name: Zetterberg, Henrik
name: Blennow, Kaj
name: Rosa-Neto, Pedro
name: Benedet, Andréa L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 1: Table S1. Demographics and biomarker information. Table S2. Cross-correlation matrix between synaptic biomarkers (Spearman’s rho correlation coefficient). Table S3. Post hoc analysis (Tukey contrasts) of the biomarker concentrations across groups, accounting for age and sex. Table S4. Standardized estimates of the linear regression models of associations between synaptic biomarkers and other CSF/imaging biomarkers, adjusted by age and sex (for future cognition, baseline scores were also accounted for in the models). Table S5. Parameters and estimates of the path analysis. Figure S1. Biomarker concentration across groups – z-scores. Figure S2. Biomarker concentration across groups – raw values. Figure S3. Individual linear associations. Figure S4. Synaptic biomarkers and brain PET. Figure S5. Interconnection of biomarkers in the AD continuum.
Trust regions in Kriging-based optimization with expected improvement
Creators: name: Rommel G. Regis
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: The Kriging-based Efficient Global Optimization (EGO) method works well on many expensive black-box optimization problems. However, it does not seem to perform well on problems with steep and narrow global minimum basins and on high-dimensional problems. This article develops a new Kriging-based optimization method called TRIKE (Trust Region Implementation in Kriging-based optimization with Expected improvement) that implements a trust-region-like approach where each iterate is obtained by maximizing an Expected Improvement (EI) function within some trust region. This trust region is adjusted depending on the ratio of the actual improvement to the EI. This article also develops the Kriging-based CYCLONE (CYClic Local search in OptimizatioN using Expected improvement) method that uses a cyclic pattern to determine the search regions where the EI is maximized. TRIKE and CYCLONE are compared with EGO on 28 test problems with up to 32 dimensions and on a 36-dimensional groundwater bioremediation application in appendices supplied as an online supplement available at http://dx.doi.org/10.1080/0305215X.2015.1082350. The results show that both algorithms yield substantial improvements over EGO and they are competitive with a radial basis function method.
Guidelines for linking HBM and health studies
Creators: name: Tolonen, Hanna
name: Andresson, Anna-Maria
name: Rambaud, Loïc
name: Tagne-Fotso, Romuald
name: Ancona, Carla
name: Lermen, Dominik
name: Virgolino, Ana
Publisher: name: Zenodo
Year: 2022
Subjects: health survey
human biomonitorin
study protocol

description: HBM and health studies, namely health examination surveys (HES), have several common components both in the planning and the preparation phase of the study, as well as in the implementation phase, namely with regard to survey contents and to fieldwork. For planning and preparation phases, for example, common features can be found in sampling, ethical and data protection, personnel requirements, and training of the survey staff. Both study types include questionnaires which can have several common modules, health measurements and collection of biological samples such as blood and urine. Sample selection and requirements for the fieldwork site as well as recruitment of participants also share several common features.
 Additional to all common features and protocols there are also specific issues/protocols from HBM and HES which differ. Therefore, the aim of these guidelines and SOPs is to provide recommendations on how HBM and HES could be combined at a national level to obtain the best synergies on fieldwork logistics, data collection and costs.
 These guidelines are based on comparison of the existing HBM and HES protocols.The guidelines and SOPs for HBM studies are based on some of the deliverables (ready and under preparation) within the HBM4EU project, experience from COPHES/DEMOCOPHES and HBM protocols/recommendations9 For HESs the guidelines and SOPs are taken from the EHES. The main purpose has been to identify survey phases and contents of the survey protocols which are common in both HBM and health studies, i.e. easily merged, and where differences exist. When protocols for HBM and HES were similar, common parts are described as recommendation for combined HBM and health survey. When differences in the protocols were observed, recommendations aims to highlight the minimum key components required for both parts (HBM and HES). For differing parts, case-by-case decisions are needed in each study to ensure that study aims are fulfilled.1
Wie Vergleichsformationen Marktstandards bestimmen. Die Einführung von Abgasgrenzwerten und Katalysatoren auf dem deutschen Automobilmarkt im Spannungsfeld von Branchen- und Verbraucherschutz
Creators: name: Klode, Sarah Elisabeth
Publisher: name: Universität Bielefeld
Year: 2024
Subjects: subject: 900

description: Das Paper befasst sich mit dem Verhältnis von Vergleichsformationen und Marktstandardisierung anhand der Einführung strenger Abgasgrenzwerte auf dem deutschen Automobilmarkt in den 1980er Jahren. Die Setzung regulativer Umweltstandards wurde von Konflikten zwischen Unternehmern und Politikern sowie intensiven Debatten in der automobilen Öffentlichkeit begleitet. Demnach hatten Standards nicht nur eine wirtschaftspolitische Dimension. Vielmehr waren sie in ein breiteres Feld gesellschaftlicher Einflüsse eingebettet. Die Analyse zeigte, dass sich die gesellschaftlichen Aushandlungsprozesse über das Phänomen des Vergleichens besonders präzise beschreiben und untersuchen ließen. Die Festlegung eines Umweltstandard für den Markt durch politische Akteure störte die etablierten Routinen des Vergleichens in Bezug auf die Wirtschaftlichkeit von Automobilen, weil so ökologische gegenüber ökonomischen Vergleichshinsichten aufgewertet wurden. Folglich waren die Konflikte um die Setzung eines Automobilstandards damit zugleich Konflikte um die Praxis, nach welchen Fahrzeugkriterien Automobile überhaupt verglichen werden sollten und wie diese zu hierarchisieren seien.
description: The paper examines the relationship between comparative practices and standardisation, using the introduction of strict emission limits in the German automotive market in the 1980s as a case study. The setting of regulatory environmental standards was accompanied by conflicts between entrepreneurs and politicians as well as intense debates in the automotive public sphere. As a result, standards did not only have an economic-political dimension. Rather, they were embedded in a broader field of social influence. The analysis has shown that the social negotiations that took place can be described and analysed with particular precision through the phenomenon of comparison. The setting of an environmental standard for the market by political actors disturbed the established routines of comparison with regard to the economic efficiency of cars, because this meant that ecological comparisons were valued more highly than economic comparisons. Consequently, the conflicts surrounding the setting of a car standard were at the same time conflicts over the practice of which aspects should be used to compare cars at all and how these should be hierarchically arranged.
Die Produktion von Vergleichswissen. Fallbeispiele aus der Vormoderne. Versuch einer Symmetrisierung
Creators: name: Aust, Cornelia
name: Wittmaack, Malte
name: Benz, Maximilian
name: Flüchter, Antje
Publisher: name: Universität Bielefeld
Year: 2024
Subjects: subject: 900

description: Mit einem Kommentar von Kirsten Kramer / Carsten Reinhardt
description: Im Working Paper werden die beiden Aspekte von Vergleichswissen herausgearbeitet: Wissen, das Vergleichen vorausgeht, das die comparata und tertia zurichtet, das den Kontext der Vergleichspraktiken darstellt, auf der einen Seite; Wissen, das durch Praktiken des Vergleichens erzeugt wird, auf der anderen Seite. Spätantike, mittelalterliche und frühneuzeitliche Fallbeispiele – typologisches Denken; Rückgriffe auf antikes Wissen; polemische Ethnographien – werden, ausgehend von spezifischen communities of practice, innerhalb von distinkten geschichtlichen, des Näheren exegetischen und ethnographischen Praxisformationen am Schreibtisch und auf Reisen, sowie in der jeweiligen epistemischen Ordnung rekonstruiert. Dabei werden Kriterien moderner ‚Wissenschaftlichkeit‘ nicht vorausgesetzt. Vormoderne Eigenlogiken, die sich in den Vergleichspraktiken mit Blick auf die Modi des Vergleichens – insbesondere den temporalen bzw. temporalisierenden Modus – analytisch fassen lassen, werden so zunächst einmal in ihrer historischen Spezifik herausgearbeitet, abschließend aber in einem Kommentar der Wissensproduktion in der Moderne kontrastiv gegenübergestellt.
description: In this working paper, the two aspects of 'Vergleichswissen' (knowledge in connection with practices of comparing) are elaborated: On the one hand knowledge that precedes comparisons, that forms the comparata and tertia and represents the context for practices of comparing; on the other hand knowledge that is generated by practices of comparing. Late antique, medieval and early modern case studies—typological thinking; references to ancient knowledge; polemical ethnographies—are reconstructed regarding specific communities of practice within the respective epistemic order and in distinct historical formations of practices. These include exegetical or ethnographical writing, the latter done from the armchair or during travel. In doing so, criteria of modern ‘academic approach’ are not assumed. Pre-modern circumstances, which can be analytically grasped in the practices of comparing with a view to the modes of comparison—in particular the temporal or temporalizing mode—are thus reconstructed in their historical specificity and contrasted in a commentary on knowledge production in modernity.
Εφοδιαστική αλυσίδα και δίκτυο διανομής στην αγορά της Ελλάδας και της Ολλανδίας
Creators: name: Φασούλας, Κωνσταντίνος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Διαχείριση εφοδιαστικής αλυσίδας
subject: Δίκτυο διανομής
subject: Συγκριτική ανάλυση
subject: Βιωσιμότητα
subject: Νέες τεχνολογίες
subject: Συνεργασία
subject: Ανθεκτικότητα

description: Η παρούσα διατριβή εμβαθύνει στο δυναμικά μεταβαλλόμενο πεδίο της διαχείρισης της εφοδιαστικής αλυσίδας, διερευνώντας βασικά θέματα της εξέλιξης, της βιωσιμότητας, των τεχνολογικών μεταρρυθμίσεων, της συνεργασίας, της ανθεκτικότητας, της ανάπτυξης δεξιοτήτων και των μελλοντικών στρατηγικών. Η εξέλιξη των αλυσίδων εφοδιασμού σε ευέλικτα, διασυνδεδεμένα δίκτυα εξετάζεται παράλληλα με την επιτακτική ενσωμάτωση των πρακτικών βιωσιμότητας. Εξετάζεται κριτικά η δυναμική της εφοδιαστικής αλυσίδας και του δικτύου διανομής στην ελληνική και την ολλανδική αγορά. Η συγκριτική ανάλυση προσφέρει πληροφορίες για τις ξεχωριστές προκλήσεις, τις ευκαιρίες και τις στρατηγικές που υιοθετούν οι επιχειρήσεις σε αυτές τις δύο αγορές. Δίνεται έμφαση στην εξέλιξη των αλυσίδων εφοδιασμού προς την ευελιξία, την ενσωμάτωση βιώσιμων πρακτικών και τον αντίκτυπο των νέων τεχνολογικών. Καθώς και οι δύο αγορές προσανατολίζονται στην ψηφιακή ολοκλήρωση και την ενσωμάτωση της βιωσιμότητας, παρέχονται στρατηγικές λήψης αποφάσεων στο σύνθετο πλαίσιο της διαχείρισης εφοδιαστικής αλυσίδας και του δικτύου διανομής.
Synthesis of deuterium-labelled substrates for the study of oleuropein biosynthesis in Olea europaea callus cultures
Creators: name: Serrilli, Anna Maria
name: Maggi, Agnese
name: Casagrande, Valentina
name: Armandodoriano Bianco
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: Plant Biology
subject: Computational Biology

description: We propose the cell culture approach to investigate oleuropein (1) biogenesis in Olea europaea L. We suggest employing olive callus cultures to identify the iridoidic precursor of oleuropein. In fact, we confirmed that callus cells from olive shoot explants are able to produce key secoiridoid as 1. To enable this approach, we synthesised and characterised deuterium-labelled iridoidic precursors belonging both to the loganin and the 8-epiloganin series. These iridoids are [7,8-2H2]-7-deoxy-8-epi-loganin (2D), [8,10-2H2]-8-epi-loganin (4D) and [7,8-2H2]-7-deoxy-loganin (3D).
Did Late Neolithic farming fail or flourish? A Scottish perspective on the evidence for Late Neolithic arable cultivation in the British Isles
Creators: name: Bishop, Rosie R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences

description: This paper critically assesses the recent claim (Stevens and Fuller 2012) that cereal agriculture was abandoned in the Late Neolithic of the British Isles. The Scottish archaeobotanical dataset is considered in detail to test the universal applicability of the model proposed by Stevens and Fuller (2012) and a series of alternative hypotheses are suggested to explain the nature of the current evidence. It is argued that the importance of arable agriculture probably varied on a local as well as a regional scale and that caution should be exercised when attempting to apply unitary models to complex datasets.
The Bridegroom’s kiss in the Song of Songs. The commentaries of Bernard of Clairvaux and William of Saint-Thierry
Creators: name: Pullano, Francesca
Publisher: name: Doctor Virtualis
Year: 2020

description: Il Cantico dei Cantici occupa un posto d'onore nella tradizione monastica e nella teologia mistica; i commenti scritti da Bernardo di Chiaravalle e da Guglielmo di Saint-Thierry esercitarono una grande influenza sulla filosofia mistica occidentale. L’articolo si concentra principalmente sul significato teoretico della filosofia monastica e il suo scopo è mostrare l'importanza del bacio come immagine della massima unione mistica tra Dio e l'anima umana nei commenti di Guglielmo e Bernardo. L'allegoria del bacio è anche analizzata e inserita nel contesto della teoria dei sensi spirituali, che ha avuto un ruolo importante nell'epistemologia di Guglielmo. La natura dell'uomo e quella di Dio sono strettamente correlate, Dio infatti lascia che l'uomo lo cerchi così come un uomo cercherebbe la sua amata. Secondo i due monaci, l'uomo, tra tutte le creature, assomiglia di più a Dio, perché è stato creato come imago Dei. Descrivendo le successive e via via più perfette forme dell'amore mistico tra gli sposi, l'autore mostra il legame che si instaura tra creatore e creatura. Lo Spirito Santo ha un ruolo fondamentale in questa dinamica amorosa e la storia tra la Sposa e lo Sposo è l’analogia dell'unione tra Dio e l'anima. The Song of Songs held a place of honour in the monastic tradition and in the mystical theology; the commentaries written by Bernard of Clairvaux and by William of Saint-Thierry, exercised a great influence on Western mystical philosophy. This paper is mainly focused on the theoretical significance of the monastic philosophy, and its aim is to show the importance of the kiss as an image of the ultimate mystical union between God and human soul in William’s and Bernard’s commentaries. The allegory of the kiss will be also analysed and placed within the context of the theory of the spiritual senses, which had an important role in William’s epistemology. Man’s and God’s nature are closely related, such that God let man seek him in an analogous way to a human would seek his beloved. According to the two monks, man, of all creatures, resembles God the most, because he is created as imago Dei. The Holy Spirit in the Song can really describe the higher levels of spirituality in terms of the fully experience of love; the love story between the Bride and the Groom is an accurate analogy of the union between God and soul.
description: Doctor Virtualis, Bd. 15 (2019): Mystik und Wissen
Trust regions in Kriging-based optimization with expected improvement
Creators: name: Rommel G. Regis
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: The Kriging-based Efficient Global Optimization (EGO) method works well on many expensive black-box optimization problems. However, it does not seem to perform well on problems with steep and narrow global minimum basins and on high-dimensional problems. This article develops a new Kriging-based optimization method called TRIKE (Trust Region Implementation in Kriging-based optimization with Expected improvement) that implements a trust-region-like approach where each iterate is obtained by maximizing an Expected Improvement (EI) function within some trust region. This trust region is adjusted depending on the ratio of the actual improvement to the EI. This article also develops the Kriging-based CYCLONE (CYClic Local search in OptimizatioN using Expected improvement) method that uses a cyclic pattern to determine the search regions where the EI is maximized. TRIKE and CYCLONE are compared with EGO on 28 test problems with up to 32 dimensions and on a 36-dimensional groundwater bioremediation application in appendices supplied as an online supplement available at http://dx.doi.org/10.1080/0305215X.2015.1082350. The results show that both algorithms yield substantial improvements over EGO and they are competitive with a radial basis function method.
Il concetto di pulchrum in Giovanni di Salisbury
Creators: name: Salvestrini, Amalia
Publisher: name: Doctor Virtualis
Year: 2020

description: Il saggio affronta la questione se nel pensiero di Giovanni di Salisbury sia presente un pensiero mistico e quella di quali siano le relazioni con la sua teoria della conoscenza. Il pulchrum rappresenta uno dei temi tramite cui è possibile riflettere su tale questione, poiché problematizza il rapporto tra umano e divino, tra immanente e trascendente, su più livelli del discorso salisburiano. All’interno del generale atteggiamento scettico dell’autore, il pulchrum si articola nelle dimensioni dell’armonia musicale cosmica e umana, come proportio o venustas; dei criteri di misura, numero e peso con cui Dio crea e che sono indici della sua ineffabilità in senso dionisiano; dell’armonia tra forma e contenuto proprie della retorica e della poesia; infine dell’ordine proporzionale che regola non solo il cosmo, ma anche la res publica. Il saggio conclude individuando un atteggiamento mistico, che non è propriamente pensiero mistico, nei momenti in cui maggiormente emergono gli aspetti di ispirazione dionisiana. The essay concerns the question of the possibility of mystical thought in the reflection of John of Salisbury and that of what is the relationship with his theory of knowledge. The pulchrum represents one of the themes through which one can approach this issue, because proves problematic the relationship between human being and God, immanent and transcendent, on multiple levels of John’s thought. Into his general sceptical attitude, the pulchrum is articulated in some dimensions of the musical harmony, both cosmic and human, such as proportio or venustas. In addition, it is understood as measure, number and weight with which God creates and that are signs of his ineffability in a Dionysian meaning. The concept of beauty is also related to the relationship between form and content concerning both rhetoric and poetry. Finally, it concerns the proportional order that regulates not only the cosmos, but also the res publica, in the moments in which the aspects of Dionysian derivation mainly emerge.
description: Doctor Virtualis, Bd. 15 (2019): Mystik und Wissen
Synthesis of deuterium-labelled substrates for the study of oleuropein biosynthesis in Olea europaea callus cultures
Creators: name: Serrilli, Anna Maria
name: Maggi, Agnese
name: Casagrande, Valentina
name: Armandodoriano Bianco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: Plant Biology
subject: Computational Biology

description: We propose the cell culture approach to investigate oleuropein (1) biogenesis in Olea europaea L. We suggest employing olive callus cultures to identify the iridoidic precursor of oleuropein. In fact, we confirmed that callus cells from olive shoot explants are able to produce key secoiridoid as 1. To enable this approach, we synthesised and characterised deuterium-labelled iridoidic precursors belonging both to the loganin and the 8-epiloganin series. These iridoids are [7,8-2H2]-7-deoxy-8-epi-loganin (2D), [8,10-2H2]-8-epi-loganin (4D) and [7,8-2H2]-7-deoxy-loganin (3D).
When the angels played: monadology and divine absconsion in Walter Benjamin
Creators: name: Costa, Elsa
Publisher: name: Doctor Virtualis
Year: 2020

description: Le interpretazioni di Walter Benjamin si estendono dall’estremo di considerarlo l’ultimo significativo uomo di lettere del periodo precedente alla seconda guerra mondiale fino all’estremo opposto di ritenerlo un rabbino hassidico. C’è accordo sul fatto che circa dal 1916-1920 Benjamin fu interessato alla teologia e alla metafisica ebraica e cristiana e che dal 1925 circa fino alla sua morte nel 1940 fu apertamente marxista e giunse fino alla quasi esclusione della metafisica. L’articolo individua le ambiguità della cosmologia teistica del primo Benjamin, sostenendo che l’instabilità intrinseca delle sue considerazioni, specialmente su linguaggio, giudizio e allegoria, lo ha costretto ad abbandonare il platonismo giovanile e ad abbracciare una cosmologia in cui Dio è nascosto. Proprio come i primi atei si ispirarono alla speculazione di Duns Scoto secondo il quale un triangolo avrebbe avuto ancora tre angoli in un universo in cui Dio non esistesse, la visione di Benjamin di un mondo abbandonato da Dio lo condusse, nel corso degli anni Venti, al materialismo ateo. Poiché il materialista Benjamin continuò, nonostante se stesso, a incontrare tracce divine e teleologia nelle sue escursioni letterarie, concluse che doveva cacciare Dio ancora più lontano dalla sua creazione per permettere all’umanità di percepirla come realmente è. Questo atteggiamento si protrasse fino all’ultimo anno di vita di Benjamin, durante il quale scelse di abbracciare la teologia come lo spirito nascosto nella lettera del materialismo storico. Interpretations of Walter Benjamin have ranged from the last pre-war man of letters to a Hasidic rabbi. There is consensus that from roughly 1916-1920 Benjamin was interested in Jewish and Christian theology and metaphysics and that from about 1925 to his death in 1940 he was vocally Marxist to the near exclusion of metaphysics. This article identifies ambiguities in Benjamin’s early, theistic cosmology, arguing that the inherent instability of Benjamin’s accounts especially of language, judgment and allegory compelled him to discard his early Platonism and embrace a cosmology in which God is abscondite. Just as early atheists took inspiration from Duns Scotus’s speculation that a triangle would still have three angles in a universe in which God does not exist, Benjamin’s vision of a world abandoned by God led him, over the course of the 1920s, into atheistic materialism. When the materialist Benjamin continued, despite himself, to encounter divine traces and teleology in his literary excursions, he concluded that he had to chase God even further from his creation in order for humanity to perceive the latter as it really was. This state of affairs continued until the last year of Benjamin’s life, during which he chose to embrace theology as the hidden spirit lurking within the letter of historical materialism.
description: Doctor Virtualis, Bd. 15 (2019): Mystik und Wissen
Cyphenothrin Flea and Tick Squeeze-On for Dogs: Evaluation of Potential Health Risks Based on the Results of Observational Biological Monitoring
Creators: name: Driver, Jeffrey H.
name: Ross, John H.
name: Holden, Larry R.
name: Selim, Sami
name: Sharp, Janice K.
name: Carlson, Dave
name: Nouvel, Larry
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Neuroscience

description: An observational biomonitoring study was conducted involving adults and children in households that purchased and applied a cyphenothrin-containing spot-on product for dogs as part of their normal pet care practices. The 3- to 6-yr-old children had greater exposure than the adult applicators in the same house, 3.8 and 0.6 μg/kg body weight, respectively. The mean measured values in children were 13-fold lower than those estimated using the U.S. Environmental Protection Agency (EPA) current standard operating procedures (SOP) for pet products (assuming 5% dermal absorption), although the maximum absorbed dosage of one child on one day was equivalent to the default value derived from the SOPs. With regard to potential human health risks, it can be concluded that despite the inherent conservatism in both the exposure and toxicology data, the margins of exposure (MOE) were consistently greater than 100 for average, 95th percentile, and maximum exposures. More specifically, the results of this study demonstrated that the MOE were consistently greater than 1,000 for mean exposures and exceeded 100 for 95th percentile and maximum measured exposures, which clearly indicates a reasonable certainty of no harm when using the cyphenothrin spot-on products. It is also noteworthy that Sergeant’s spot-on products containing cyphenothrin currently sold in the United States have lower weight percentages of active ingredient and lower applied amounts than those used by all but two of the participant households in this study.
Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa
Creators: name: Kim, Jang Hoon
name: Abubaker M. A. Morgan
name: Bui Huu Tai
name: Van, Doan Thi
name: Nguyen Manh Cuong
name: Kim, Young Ho
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The aim of this study is to search for soluble epoxide hydrolase (sEH) inhibitors from natural plants, bioassay-guided fractionation of lipophilic n-hexane and chloroform layers of an extract of the aerial parts of Glycosmis stenocarpa led to the isolation of 12 compounds (1–12) including murrayafoline-A (1), isomahanine (2), bisisomahanine (3), saropeptate (4), (24 S)-ergost-4-en-3,6-dione (5), stigmasta-4-en-3,6-dion (6), stigmast-4-en-3-one (7), β-sitosterol (8), 24-methylpollinastanol (9), trans-phytol (10), neosarmentol III (11) and (+)-epiloliolide (12). Their structures were elucidated on the basis of spectroscopic data. Among them, neosarmentol III (11) was isolated from nature for the first time. All the isolated compounds were evaluated for their inhibitory activity against sEH. Among isolated carbazole-type compounds, isomahanine (2) and bisisomahanine (3) were identified as a potent inhibitor of sEH, with IC50 values of 22.5 ± 1.7 and 7.7 ± 1.2 µM, respectively. Moreover, the inhibitory action of 2 and 3 represented mixed-type enzyme inhibition.
La fatica mistica di Michele Federico Sciacca. Un travaglio che procede da lontano
Creators: name: Amorosino, Valentina
Publisher: name: Doctor Virtualis
Year: 2020

description: L’obiettivo che questo lavoro si propone è quello di rintracciare nella prosa appassionante e appassionata di Michele Federico Sciacca tracce che rimandano alla speculazione filosofica di Bernardo di Chiaravalle. Divisi nel tempo, ma compartecipi di un modo comune di intendere la categoria mistica, i due filosofi appaiono uniti nella condivisione di una stessa sensibilità. È una filiazione che accoglie più interrogativi che certezze, primo tra tutti, il perché Sciacca non citi mai direttamente Bernardo, cosa che invece ripetutamente fa con Agostino, Tommaso, Bonaventura, e altre colonne portanti del pensiero. Sono molte in tal senso le ipotesi che vengono prese in considerazione, tra queste l’idea che per il filosofo di Giarre, Bernardo fosse non una semplice fonte, ma una lente attraverso la quale guardare meglio e più lontano. Un legame taciuto dunque, tenuto a riparo dalla vista dei più, quello che Sciacca ha lasciato crescere tra le pieghe dei suoi scritti. I due filosofi sfidano il tempo e si trovano, o ri-trovano dentro una sincronicità filosofica che li vede messaggeri dagli stessi valori. In questo forse “immaginario” dialogo tra un pensatore che ha saputo sporgere lo sguardo oltre il suo secolo, e uno che non ha mai perso occasione per riflettere e riflettersi attraverso il passato, è possibile ritrovare e godere della tensione emotiva dell’essere umano che pretende di ricongiungersi con l’Assoluto. The aim of this paper is to find in Michele Federico Sciacca’s fascinating and passionate prose traces that refer to Bernard of Clairvaux philosophical speculation. Distant in time, but sharing a common way of understanding the mystical category, the two philosophers appear united in having the same sensitivity. It is a filiation that welcomes more questions than certainties. First of all, why Sciacca never quotes Bernard directly, something that instead he repeatedly does with Augustine, Thomas, Bonaventure, and many others. In this sense, many hypotheses are taken into consideration, including the idea that for the philosopher of Giarre, Bernard was not just a source, but a lens through which to look better and further awy. A silent relationship, therefore, kept away from the sight of most, that which Sciacca has allowed to grow between the folds of his writings. The two philosophers defy time and find themselves, or refind within a philosophical synchronicity that sees them as messengers of the same values. In this perhaps “imaginary” dialogue between a thinker who has been able to look beyond his century, and one who has never missed an opportunity to reflect and reflect through the past, we can find and enjoy the emotional tension of the human being who claims to reconnect with the Absolute.
description: Doctor Virtualis, Bd. 15 (2019): Mystik und Wissen
Strange bedfellows: la ricerca dell’assoluto, dal misticismo medievale all’era del misticismo digitale
Creators: name: Barbierato, Enrico
Publisher: name: Doctor Virtualis
Year: 2020

description: Nella Tempesta shakespeariana, le avversità della vita obbligano il povero Trinculo a condividere il giaciglio con qualcuno assai differente da lui (Misery acquaints a man with strange bed-fellows). Si tratta di un’immagine che rappresenta il momento in cui due individui (e, in senso traslato, due concetti) radicalmente diversi sono obbligati a percorrere il medesimo cammino per realizzare uno scopo comune. In questo lavoro, sostengo che alcune delle interpretazioni del misticismo medievale possono identificarsi in una forma di esperienza digitale basata sul World Wide Web, il quale, grazie al rapido sviluppo delle metodologie dell’Intelligenza Artificiale, si appresta a diventare una nuova forma di misticismo. In Shakespeare’s Tempest, the misfortunes of life force poor Trinculo to share a bed with a stranger in order to survive. This image represents the moment where two persons (or even two concepts), utterly different in their perspectives, share a path in order to achieve a common goal. In this article, I put forward the claim that some interpretations of Middle Ages philosophy can be identified as a form of digital experience based on the World Wide Web, which, thanks to the rapid development of Artificial Intelligence methodologies, opens up a new kind of mysticism for the future era.
description: Doctor Virtualis, Bd. 15 (2019): Mystik und Wissen
Misticismo: sentieri che si biforcano
Creators: name: Parodi, Massimo
Publisher: name: Doctor Virtualis
Year: 2020

description: La mistica, come l’essere, si può dire in molti modi diversi e questi modi non possono essere presi in considerazione in maniera sistematica. Accostando autori non considerati mistici in senso proprio, si intende fornire qualche spunto di riflessione, mostrando come aspetti tradizionalmente considerati mistici, si possano trovare nei più diversi ambiti: scienza, filosofia, poesia, politica. Se questo livello del pensiero è indispensabile per non cedere alle pretese tiranniche della ragione analitica, è opportuno in ogni caso evitare di farne un mondo a parte che si nutre della propria diversità e del proprio orgoglio. Mysticism, as well as being, can be said in many different ways and these ways cannot be taken into account in a systematic way. By comparing authors not considered mystical in the proper sense, we intend to provide some ideas for reflection, showing how aspects traditionally considered mystical can be found in the most diverse contexts: science, philosophy, poetry, politics. If this level of thought is indispensable in order not to submit to the tyrannical claims of analytical reason, it is necessary in any case to avoid making it a separate world that is nourished by its own diversity and pride.
description: Doctor Virtualis, Bd. 15 (2019): Mystik und Wissen
ОРГАНІЗАЦІЙНО-ТЕХНОЛОГІЧНІ ЗАСАДИ  ІНКЛЮЗИВНОЇ ОСВІТИ У ПОЧАТКОВІЙ ШКОЛІ
Creators: name: Хом'як, Ольга
Publisher: name: Academician Stepan Demianchuk International University of Economics and Humanities
Year: 2023
Subjects: Організаційно-технологічні засади
Інклюзивна освіта
Початкова школа

description: Методичні рекомендації до проведення практичних, лабораторних занять та самостійної роботи з навчальної дисципліни «Організаційнотехнологічні засади інклюзивної освіти у початковій школі» для здобувачів другого рівня вищої освіти (магістерського), галузі знань 01 Освіта/Педагогіка, спеціальності 013 «Початкова освіта» / уклад. О. А Хом'як. Рівне : видавець О. Зень, 2023. 124 с.
description: Методичні рекомендації містять комплекс матеріалів, структурованих відповідно до навчальної програми дисципліни «Організаційно-технологічні засади інклюзивної освіти у початковій школі». Змістове наповнення охоплює аудиторну, самостійну та індивідуально-дослідну роботу студентів, надаючи їй системності, послідовності, сприяє формуванню цілісного погляду на проблеми навчальної дисципліни та розвитку достатнього рівня узагальнення матеріалів.Рекомендується для студентів педагогічних факультетів.
Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach
Creators: name: Poli, Giulio
name: Gelain, Arianna
name: Porta, Federica
name: Asai, Akira
name: Martinelli, Adriano
name: Tuccinardi, Tiziano
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Signal transducer and activator of transcription 3 (STAT3) plays an essential role in cell growth regulation and survival. An aberrant STAT3 activation and/or expression is implied in various solid and blood tumors as well as in other pathologies like rheumatoid arthritis and pulmonary fibrosis, thus making the search for STAT3 inhibitors a growing field of study. With the aim of identifying new inhibitors of STAT3 dimerization, we screened a database including more than 1 320 000 commercially available compounds using a receptor-based pharmacophore model comprising the key protein–protein interactions identified in the STAT3 dimer and refining the search through docking and molecular dynamic simulations studies. STAT3 binding assays revealed a significant STAT3 inhibitory activity and selectivity versus Grb2 for one of the four top-scored compounds, thus verifying the reliability of the virtual screening workflow. Moreover, such compound could already be considered as a lead for the development of new and more potent STAT3 dimerization inhibitors.