cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
All Saints Church, Thorpe Abbots, Norfolk
Creators: name: Hart, Stephen
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 5-6, 104-106
description: Of about 180 round west towers on English churches, all except five are in East Anglia and most are flint built. Until recently it was widely accepted that most were Norman and that where the belfry stage was octagonal it was a post- Norman addition. Over 50 medieval round towers have octagonal upper stages and recent studies of their fabric suggest that in more than 20 the circular stage is post-Norman and the octagon contemporary with it. In all of these, except for three where the tower arch was probably originally a west nave entrance, or the whole tower replaces an earlier one, a pointed tower arch corroborates a post-Norman date. The number of towers with octagonal stages with lancet or early-c 14th- belfry openings that are contemporary with the circular stage compared to those with added c 15th-century belfries suggests that the architectural trend of an octagonal belfry stage on a circular base first appeared as towers purpose-built to that design - to be followed later by those in which an octagon apparently replaced the original circular belfry of a Norman tower.
Development of a monocyte microassay to measure Fc-dependent clearance of erythrocytes
Creators: name: Olson, Ann Tona
Publisher: name: University of Utah
Year: 2013

description: Drugs which modulate the immune system have been used therapeutically to benefit a variety of populations. Vaccines which impart active immunity against bacteria and viruses have markedly altered the spread of communicable diseases. Corticosteroids produce immunosuppressive effects which have been extensively utilized to treat disorders of aberrant immunity and have proved effective in altering the inflammatory process in autoimmune diseases. Cytotoxic agents, such as azathiorpine and cyclophosphamide, were originally developed for their anticancer effects but have been widely used for the immunosupressive activity in transplantation rejection reactions and in the treatment of autoimmune diseases. The purpose of this project was to reproduce a monocyte microassay to study Fc-dependent clearance of antibody-coated erythocytes. Once validated, this microassay could be used to study the mechanism by which methldopa and other drugs may alter Fc-dependant clearance. An adaptation of the microassay described by Fleer and colleagues was utilized.
Erlaubnisurkunde für Johannes Itten zum Betrieb einer privaten Zeichen- und Malschule
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1927

description: Erlaubnisurkunde zum Betrieb einer privaten Zeichen- und Malschule an der Potsdamer Strasse 75, Berlin, ausgestellt vom Preussischen Provinzial-Schulkollegium Berlin / Enthält auch: 1 Fotokopie der Erlaubnisurkunde / Umfang: 1 Blatt gefalten, 3 Seiten beschrieben
Procession de la Sanch, vendredi saint. Suite du miserere des pendus, cloche et roulements de tambour annonçant le salut du caparuxo (pénitent) vêtu en rouge au Dévôt Christ
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2022

Abstract
Gloucester Cathedral: a painted floor in the choir gallery
Creators: name: Bagshaw, Steve
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 5-6, 107-109
description: The south choir gallery is a late 1 lth-century structure modified in the mid14th century, as is the adjoining south transept east gallery chapel (Welander 1991, 150; Wilson 1985, 73). A single brick floor laid in a simple herringbone pattern extends throughout both of these galleries; documentary evidence, in the form of building accounts, provides a date in the 1670s for laying this floor with 8,900 bricks purchased from Worcester (Welander 1991, 373). This brick pavement was partially lifted in 1935 revealing a geometric pattern in an underlying surface. The feature was photographed at the time (ibid, 374), but was interpreted as a mortar bed for the brick floor. During 2001 the brick floor was lifted along several narrow channels for inserting cables, as part of improvements to the fire precautions being carried out in the cathedral. Nine trenches, 200-300mm in width, were cut by maintenance staff, involving removal of some bricks and excavation of the substrate to a depth of 100-150mm below current floor level. The level at which this 'mortar bed' floor was encountered was 130-l40mm below the present 17th century brick pavement. A total of 44m was cut in this way.
The effect of diflunisal administration on the pharmacokinetics and metabolic fate of acetaminophen in man
Creators: name: Klumpe, David Brian
Publisher: name: University of Utah
Year: 2013

description: Diflunisal is a fluorinated derivative of salicylic acid. It was synthesized with the intention of increasing potency, enhancing gastrointestinal tolerance and increasing duration of action over that of salicylate. Diflunisal is completely absorbed after oral administration and reaches peak plasma concentrations in two to three hours. It is highly bound to albumin, as is salicylate, with binding approaching 98-99%. Lin, et al observed a ten-fold increase in unbound diflunisal concentrations as total plasma concentratiojns ranges from 5 to 300 mcg.mL, demonstrating that diflunisal binding is concentrate-dependent. Diflunisal is extensively metabolized within the liver by UDP-glucuronosyltransferase to glucuronic acid conjugates; less than 5% of a dose is excreted unchanged in the urine. Diflunisal forms both an ether and ester glucuronide, which are excreted in the urine in nearly equal amounts.  Acetaminophen is a widely used nonprescription analgesic and antipyretic which is also included in many combination prescription analgesic products. The rate of acetaminophen absorption is a function of the time required for gastric emptying. Peak plasma concentrations are reached within one hour of administration. Because both acetaminophen and diflunisal are metabolized to glucuronide conjugates, mutual inhibition of elimination may occur with concomitnat administration. The objectives of this investigation, were to: 1.) To describe the effect that diflunisal administration has on acetominophen pharmacokinetics in healthy volunteers and; 2.) To describe the mechanism9s0 responsible for this interaction if it were to occur.
Empirical correlation of quantified hard carbon structural parameters with electrochemical properties for sodium-ion batteries using a combined WAXS and SANS analysis
Creators: name: Kalder, Laura
name: Olgo, Annabel
name: Lührs, Jonas
name: Romann, Tavo
name: Härmas, Riinu
name: Aruväli, Jaan
name: Partovi-Azar, Pouya
name: Petzoldt, Albrecht
name: Lust, Enn
name: Härk, Eneli
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 530

description: This study highlights the advantages of using wide-angle X-ray scattering (WAXS) and small-angle neutron scattering (SANS) methods to analyse turbostratic d-glucose-derived hard carbons (GDCs) over a wide range of length scales. It demonstrates the reasons for the superior performance of hard carbons (HCs) pyrolysed at 1100 °C compared to those pyrolysed at 700 °C, 1000 °C, or 1400 °C in sodium-ion batteries (SIBs). Twelve WAXS and thirteen SANS structural parameters were simultaneously determined for HCs. The investigation incorporates WAXS-derived interlayer spacing, a3, into the SANS analysis of HCs. The Ruland and Smarsly algorithm is emphasised over the commonly used Scherrer and Bragg equations. Thus, the collective analysis of nanostructure highlights the necessity for a revision in applying widely used characterisation techniques when dealing with disordered HCs. The study suggests that an a3 value of 0.373 nm best suits GDC-1100 as a SIB anode material. Comparing HCs prepared at different pyrolysis temperatures, GDC-1100 exhibits the most compatible parameters, resulting in the highest specific capacity value. The model-free SAS analysis indicates hierarchical structural changes at nanoscopic (SANS) and atomic (WAXS) scales simultaneously. The interplay between dynamic a3 and static parameters, such as the graphene layer extent La and the Ruland length, lR, favours plateau capacity, contributing to sodium ion storage. The study demonstrates the suitability of the WAXS/SANS toolbox for empirically correlating hard carbons' structural characteristics with the electrochemical performance of SIBs.
Pulmonary diseases in older patients : understanding and addressing the challenges
Creators: name: Joshi, Pushpa Raj
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: As the global population ages, pulmonary diseases among older people have emerged as a significant and growing public health concern. The increasing incidence of these conditions has led to higher rates of morbidity and mortality among older adults. This perspective study offers a thorough overview of the prevalent pulmonary diseases affecting the elderly demographic. It delves into the challenges encountered during the diagnosis and management of these conditions in older individuals, considering factors such as comorbidities, functional limitations, and medication complexities. Furthermore, innovative strategies and personalized interventions such as precision medicine, advanced therapies, telemedicine solutions, and patient-centered support systems aimed at enhancing the care provided to older individuals grappling with pulmonary disorders are thoroughly explored. By addressing the unique needs and complexities of this vulnerable population, healthcare systems can strive towards improving outcomes and enhancing the quality of life for elderly individuals affected by pulmonary diseases.
The Origin of Young Stellar Populations in NGC 1783: Accretion of External Stars
Creators: name: Wang, Li
name: Deng, Licai
name: Pang, Xiaoying
name: Wang, Long
name: de Grijs, Richard
name: Milone, Antonino P.
name: Li, Chengyuan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The presence of young stellar populations in the Large Magellanic Cloud cluster NGC 1783 has caught significant attention, with suggestions ranging from it being a genuine secondary stellar generation to a population of blue straggler stars or simply contamination from background stars. Thanks to multi-epoch observations with the Hubble Space Telescope, proper motions for stars within the field of NGC 1783 have been derived, thus allowing accurate cluster membership determination. Here, we report that the younger stars within NGC 1783 indeed belong to the cluster, and their spatial distribution is more extended compared to the bulk of the older stellar population, consistent with previous studies. Through N-body simulations, we demonstrate that the observed characteristics of the younger stars cannot be explained solely by blue straggler stars in the context of the isolated dynamical evolution of NGC 1783. Instead, accretion of the external, low-mass stellar system can better account for both the inverse spatial concentration and the radial velocity isotropy of the younger stars. We propose that NGC 1783 may have accreted external stars from low-mass stellar systems, resulting in a mixture of external younger stars and blue straggler stars from the older bulk population, thereby accounting for the characteristics of the younger sequence.
description: 11 pages, 6 figures; accepted for publication in ApJ
Antiquitates linguarum
Creators: name: Faesch, Remigius
Publisher: name: [s.n.]
Year: 1600

description: Der Band ist in rund 70 Abteilungen gegliedert, dazwischen und teils auch innerhalb der Abteilungen sind zahlreiche Blätter für Nachträge leer gelassen. Die Einträge enthalten Büchertitel, kurze Auszüge über die in Frage stehenden Sprachen und Schriftzeichen, Inschriften sowie Bemerkungen über die Bibliotheken des Sprachwissenschaftlers Johann Buxtorf, des Mediziners Felix Platter und des Remigius Faesch.
description: Remigius Faesch
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Aus dem Museum des Remigius Fäsch 1823 in die Universitätsbibliothek gelangt. Weder in Faeschs eigenhändigem Katalog seiner Bücher (AR I 11) noch in Daniel Hubers Verzeichnis der Faeschischen Handschriften (AR I 16) aufgeführt.
description: Verzeichnung=Description=Inventaire Dez. 2009 Titel, Entstehungszeit, Sprache, Vorbesitzer, Signatur nach: Binz, ungedruckte Beschreibung
description: Verzeichnung=Description=Inventaire März 2012 Minimalaufnahme nach: Binz (1937)
description: Verzeichnung=Description=Inventaire Mai 2019 HAN-Katalogisierungsregeln Normalaufnahme auf der Basis von Binz (1937) Flury
description: Verzeichnung=Description=Inventaire September 2019 revidiert Müller/Flury
description: Erschliessungsniveau Normalniveau
Meteorologische Beobachtungen
Creators: name: Huber, Daniel
name: Merian, Emanuel
Publisher: name: [s.n.]
Year: 1776

description: Der Band enthält nebst Baviers tabellarischen Aufzeichnungen einen Brief von Emanuel Merian, mit welchem er erstere am 22. Mai 1801 an Daniel Huber übersandte  (5r), ausserdem eine ausführliche Anmerkung Hubers über Inhalt und Umstände der Aufzeichnungen sowie seine konservatorische Behandlung derselben (1r-4v).
description: M. Bavier
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch, Französisch
description: Verzeichnung=Description=Inventaire Februar 2021 Minimalaufnahme HAN-Katalogisierungsregeln
description: Verzeichnung=Description=Inventaire März 2020 Kurzkatalogisat für Digitalisierung HAN-Katalogisierungsregeln
description: Verzeichnung=Description=Inventaire Mai 2021 Normalaufnahme HAN-Katalogisierungsregeln Helena Müller
description: Digitalisierung=Digitization=Numérisation November 2021 TIFF
Procession de la Sanch, vendredi saint. Salut du caparuxo (pénitent) rouge au Dévôt Christ
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2022

Abstract
Lichfield Cathedral: archaeology of the nave sanctuary
Creators: name: Rodwell, Warwick
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 1-6
description: Excavation in the second bay of the nave of Lichfield Cathedral yielded remarkable and wholly unexpected results. These included elements of the Anglo-Saxon church and a sunken chamber over which a canopy of honour had been erected. This may be the primary site of the shrine of St Chad, which remained a focus through the Norman and Gothic reconstructions of the building. The position was finally abandoned in the 14th century, when Bishop Langton erected a costly new shrine in the eastern arm. The discovery of a pre-Viking sculptured and painted limestone panel, potentially an Annunciation scene from the shrine, is an art object of European importance. Several medieval priests graves were found: one contained a partially preserved oak coffin and other accoutrements of exceptional interest. No English medieval burial has hitherto yielded evidence of a painted cross on the fabric covering of the coffin lid, or of the consecrated Host being buried with the funerary chalice and paten. The remnants of the eucharistic wafer and linen napkin (corporal,) must surely be the oldest found in Britain. It has hitherto been held that pewter chalices and patens were made especially for mortuary use and were only symbolic. That they could be buried holding the Host sheds new light on English sepulchral history.
Permanent Easter Sepulchres: a Victorian re-creation?
Creators: name: Herbert, Christopher
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 7-19
description: During the last twenty years there has been a renewed interest in Easter sepulchres. It was Pamela Sheingorns ground- breaking work which brought increased attention to them. 1 More recently, Eamon Duffy, in Stripping of the Altars, wrote of Easter sepulchres in this way: ... the most imaginatively compelling of the Good Friday ceremonies, though associated with the cross, came after the solemn liturgy had ended. This was the custom of the 'burial' of Christ in the Easter sepulchre, an observance which left a deep mark not only in the minds of medieval English men and women but in the very structure of many parish churches. 2 I shall be arguing in this essay that Duffy is overstating his case and that the claim that the structure of very many parishes provides evidence for the ubiquity of permanent Easter sepulchres is not well founded, either. In order to explain why I have reached such radical and unexpected conclusions (unexpected and, indeed, unwelcome to myself), I shall need to outline the story of Easter sepulchres in England from their beginning.
Mémoire sur les recherches des antiquités de l'Helvétie de 1800 à 1810
Creators: name: Parent, Aubert Joseph
Publisher: name: [s.n.]
Year: 1800

description: Römische Archäologie der Schweiz. Beschreibungen von Augusta Raurica, Solothurn und Umgebung, Vindonissa, Avenches, Neuchatel sowie Lausanne und Umgebung.
description: Französisch
description: Tatarinoff, Eugen: Beiträge zur solothurnischen Altertumskunde, Nr. 1 (1911).
description: Verzeichnung=Description=Inventaire Juli 2011 sf Aufgrund des Katalogs von Erhard Flury. Typoskript in ZB Solothurn.
The church of Saint Mary at Linton Near Ross
Creators: name: Yeates, Stephen
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 21-32
description: Structural assessment and documentary research on the church of Saint Mary, Linton, in Herefordshire and its wider territorial context indicated that it was an important pre-Conquest mother church. This paper describes the historical perspective, the likely phasing of this complex building, the materials used and their probable source.
Sonnenfleckenzeichnung Nr. 22164.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.03.1966, erstellt von Berthold Hermes
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1966

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Prescribing of neuroleptics for geriatric nursing home patients: a focus on indications and dosing
Creators: name: Cantu, Thomas Gerard
Publisher: name: University of Utah
Year: 2013

description: America's elderly is the fastest growing segment of our population and as a result, the demands on the health care system to provide care for these citizens have increased. Although part of this demand was met by the establishment of long term care facilities (skilled nursing homes), the quality of care provided by some of the early institutions was less than optimal. In the early 1970s, Townsend reported on nursing home problems in America. Her text effectively focused public attention on the potential inadequacies of nursing homes through the testimonies of the investigators, nursing home employees and the patients' families. In June, 1974, the Department of Health, Education and Welfare approached this problem through their Long Term Care facility Improvement Campaign. One component of this effort involved the assessment of physician prescribing patterns in skilled nursing facilities.  The objectives of this study is to 1.) Report the incidence of neuroleptic drug use in the geriatric nursing home population.; 2.) To report the incidence of physician documentation of the need for neuroleptics in geriatric nursing home patients; 3.0 To examine the indications for neuroleptics and the dosages prescribed in llight of two sets of criteria: those developed by the National Institute of Mental Health and those assembled by the investigator.
D2.4 - Technical, Operational and Interoperability  Specifications and Architecture
Creators: name: European Centre for Medium-Range Weather Forecasts
name: NVCR
name: CINECA
name: HES-SO
name: Euro-Mediterranean Center for Climate Change
name: Danaos (Cyprus)
name: Center for Security Studies
name: eBOS Technologies (Cyprus)
name: ENG
name: IES
name: MEEO
name: Fraunhofer Institute for Transportation and Infrastructure Systems
Publisher: name: Zenodo
Year: 2023
Subjects: EO4EU
Earth Observation
techinical requirements

description: The deliverable provides a first version of the ΕΟ4ΕU technical requirements that will form the basis for the definition of the Platform and EO4EU architecture and detailed design.  In keeping with the overall project workflow, the requirements captured and synthesized here will be given to WP3 as input for the first development cycle. Within the deliverable a description of the architecture to tiers is presented. An analytical representation of components and their class diagram is described. The interaction between the components is presented in sequence diagrams also.
Crooked churches and saintly sunrises
Creators: name: Muirden, James
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 33-43
description: The hypothesis that churches in England may have been built to face the sunrise on the day of their patronal festival has been rejected by most researchers. The writer suggests that their fieldwork has been inadequate and their data analysis faulty. Having explained his reasons, he gives examples of individual churches and groups of churches encountered in his Devon survey whose alignment characteristics are consistent with the 'patronal sunrise' theory. Not only is it possible to deduce the date of dedication but the relevant saint, even when the original dedication has been changed or lost; this has potential for understanding more about pre-Conquest churches and for closer dating of buildings. Further work is needed to see whether there are regional variations. An appendix sets out his methodology.
The Design, development, implementation, and evaluation of a computerized anesthesia charting system.
Creators: name: Wang, Xiaodong
Publisher: name: University of Utah
Year: 2012
Subjects: Medical Informatics Applications
Medical Records Systems, Computerized

description: A Computerized Anesthesia Charting System (CACS) was developed and implemented as an addition to the HELP hospital information system at LDS Hospital in Salt Lake City, Utah. Instead of using the traditional manually recorded anesthesia record, the anesthesiologists charted using a computer terminal mounted on the anesthesia delivery machine. CACS automatically captured patient physiological variables as well as demography, laboratory, Admit-Discharge-Transfer (ADT), and operation timing data during the surgical anesthesia. Computer programs were developed for anesthesia data entry, display, storage, and report generation. Results of evaluation showed that anesthesiologist's average charting time was reduced by 34.3% (from 20.4% to 13.4%, P = 0.0001 by two tailed t-test). The average time spent on scanning the area was reduced by 46.7% (from 10.5% to 5.6%, P = 0.0011 by two tailed t-test). The average time spent on patient preparation was increased by 29.7% (from 10.1% to 13.1%, P = 0.0204 by two tailed t-test). The average time spent on arranging equipment was increased by 26.6% (from 6.4% to 8.1%, P = 0.0303 by two tailed t-test). The average time spent on non-anesthesia activities was increased by 81.0% (from 6.3% to 11.4%, P = 0.0137 by two tailed t-test). Results of the evaluation did not show significant differences in the anesthesiologist's average time spent on mixing and administrate drugs (from 13.2% to 14.3, P = 0.3217 by two tailed t-test), observing the patient (from 10.9% to 10.5%, P = 0.0691 by two tailed t-test), observing monitors and instruments (from 8.8% to 10.5%, P = 0.0852 by two tailed t-test), and transfer data (from 8.4% to 8.2%, P = 0.8931 by two tailed t-test). The computerized anesthesia record was more legible, complete, and accurate. The overall assessment of the CACS by anesthesiologists was positive. The computerized anesthesia charting was preferred by the anesthesiologists who after one or two training sessions used the system on their own.
Timber fittings and fixtures in churches and secular buildings: mid 14th-century timber stairs at Brabourne, Kent
Creators: name: Gardiner, Mark
name: Brown, David
name: Murray, Emily
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 45-49
description: A staircase in the church of St Mary the Virgin, Brabourne, was examined as part of a wider study of medieval buildings. Few original stairs survive in vernacular houses because of strenuous use over a long period of time. The Brabourne staircase, situated in an inconspicuous position used only for access to the belfry, and distinctly primitive in construction, was possibly contemporary with the building of the tower in c 1180. This paper describes the stairs and the investigation into its manufacture and date.
Procession de la Sanch, vendredi saint. Fin du passage de la Procession
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2022

Abstract
Rood stairs - an analysis based upon a systematic sample from three English counties
Creators: name: Schwieso, Joshua
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 51-65
description: This paper explores a long-neglected subject; this detailed survey examines the identification of rood stairs and rood screens, their numbers and positions and the reasons for their survival in west Somerset, west Cornwall and part of north Norfolk. It discusses their relationship with chancel, nave and tower, turret forms, stair types and numbers, the placing of windows for lighting as well as postulating their function, date and who they were for. The author is currently working on a survey of all the rood stairs of Somerset.
Hydrophilic-hydrophobic microphase-separated block copolymers:  synthesis, characerization and blood compatibility.
Creators: name: Grainger, David William
Publisher: name: University of Utah
Year: 2012
Subjects: Platelet Adhesiveness
Polymers
Technology, Pharmaceutical

description: Two types of amphiphilic block copolymers--one containing repeating blocks of poly(ethylene oxide) (PEO) and polystyrene (PS) and another containing poly(dimethylsiloxane) (PDMS), PEO, and heparin (Hep)--were synthesized to examine the effects of hydrophilic-hydrophobic balance on blood compatibility. Unlike analogous random copolymer systems, these amphiphilic block copolymers demonstrated various degrees of phase separation, providing a macromolecular hydrophilic-hydrophobic chain segment distribution and microscale ordered surface heterogeneity.  In the PEO-PS multiblock copolymer synthesis, functionalized telechelic prepolymers were coupled in solution. Synthesis of the triblock of PDMS-PEO-Hep involved solution coupling of PDMS to derivatized diamino PEO with various diisocyanates. Subsequent coupling of the primary amine group on the derivatized PEO chain to solubilized heparin was achieved via carbodiimide activation of heparins carboxylic groups as well as by reductive amination using sodium cyanoborohydride. Bulk characterization involved GPC, DSC, FTIR, and NMR methods. Surface analysis utilized contact angle, ATR/FTIR, ADESCA, and transmission electron microscopy. Varying degrees of phase mixing and phase-separation were observed. Differences between bulk and surface compositions were significant and generally involved surface enrichment by the low-energy (hydrophobic) blocks. Hydration effects, as monitored by contact angle, showed changes in surface composition and mobility.  In vitro evaluation by coagulation assays and platelet adhesion and activation assessments demonstrated interesting differences between block copolymers and their homopolymer controls. Those results were correlated with whole blood ex vivo results from implantation in low flow-rate shunts in rabbits. Copolymer coatings on the interior lumens of these shunts showed increased times to occlusion for block copolymers over their homopolymer controls. Improved blood compatibility was attributed to the unique heterogeneous hydrophilic-hydrophobic character demonstrated in these block copolymer systems.
The synthesis and study of novel selenazolidines: potential cancer chemopreventive agents.
Creators: name: Short, Megan D.
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolism
Chemotherapy

description: Selenium-containing compounds have been studied extensively for their cancer chemo-preventive properties.  Although many of these drugs, such as sodium selenite or 1,4-phenylenebis(methylene)selenocyanate(p-XSC), have shown promise as anticancer agents, the toxicity of such compounds limits their usefulness.  A selenocysteine prodrug is proposed to supply selenium in a less toxic manner by utilizing selenocysteine beta-lyase to provide selenium in a biochemically available form.  This prodrug approach would overcome the instability and potential toxicity associated with selenocysteine alone, but allows slow release of the active component to proved chemoprevention.  A novel prodrug of selenocysteine, 2-oxoselenazolidine-4-carboxylic acid (OSCA), was synthesized and preliminary biological data collected utilizing Chinese hamster lung fibroblast cells. Toxicity data collected on both the L- and D- isomers of OSCA showed a significant reduction in cytotoxicity as compared with the parent compound, selenocysteine.  OSCA was also less toxic than other selenium-containing compounds such as sodium selenite, sodium selenite, selenomethionine and  p-XSC.  Studies were conduced to determine if OSCA released the active component, selenocysteine.  Enzymatic hydrolysis studies of OSCA with 5-oxoprolinase were attempted, but were not successful.  Additionally, non-enzymatic studies were carried out and compared with the sulfur-containing compounds, 2-thiazolidine-4-carboxylic acid (OTCA).  As expected OSCA showed no significant hydrolysis under physiological condition, much like OTCA.  Finally, glutathione peroxidase induction (GSH-Px) was studied to determine if OSCA provided selenium in a biochemically available form.  The results were compared to sodium selenite and p-XSC.  Neither L- or D-OSCA showed induction of GSH-Px in preliminary studies.  In conclusion, these studies provide evidence that prodrug forms of selenocysteine can reduce toxicity commonly associated with selenium-containing compounds.  However, further investigation is warranted to determine their effectiveness at providing selenium for protein synthesis or other metabolic pathways that may provide cancer  chemo-preventive effects.
An evaluation of the accuracy and cost effectiveness of a reflectance photometer for monitoring blood glucose concentration in the hospital setting
Creators: name: Cunningham, Patrick James
Publisher: name: University of Utah
Year: 2013

description: Euglycemia is the goal of therapy for diabetic patients receiving insulin or oral hypoglycemic medications. Without proper control of blood glucose concentration serious» complications may occur, such as, ketoacidosis or hypoglycemic shock. Historically, monitoring outpatient blood glucose has been accomplished by measuring the urine glucose content. Urine glucose indirectly reflects blood glucose concentration of 180 mg/dl or greater depending upon the glucose threshold of the patient's kidneys, and is inadequate in detecting hypoglycemia. Until recently, directly measuring a patient's blood glucose concentration was a process requiring a clinical laboratory and a trained phlebotomist to obtain blood for glucose analysis. With the advent of glucose reagent strips and reflectance photometers, home blood glucose monitoring has now become a possible alternative to urine glucose testing. Numerous reports and studies have defined the role of reagent strips and reflectance photometers in blood glucose monitoring procedures.
The pharmacology of anticonvulsant drug combinations.
Creators: name: Weaver, Lawrence Clayton
Publisher: name: University of Utah
Year: 2012
Subjects: Pharmacology
Drug Combinations

description: This study represents the initiation of a systematic laboratory investigation designed to elucidate the type of interaction of anticonvulsant drugs and to disclose any unusual potentiation or antagonism by obtaining quantitative data on the potency and toxicity of various anticonvulsant drug combinations.  Procedures have been described for the study of antiepileptic drug combinations in which one or both components of the mixture are active when measured by a given test.  In addition, a graphic method has been described for selecting combination of two active drugs on the basis of components of effectiveness, and the details of a statistical analysis presented for determining whether the observed results are significantly different from the calculated (expected) results.  The limitations of these procedures have been discussed with recommendations for future applications.  Eleven pairs of anticonvulsants drugs combined in 45 different ratios were tested for anticonvulsant potency in rats or mice by the maximal electroshock seizure pattern test.  In addition, the quality of drug required to produce minimal neurological deficit in 50 percent rate of rats of mice was determined for 31 of the mixtures, and protective indices for these mixtures were calculated.
Psychostimulants and the vesicular monoamine transporter
Creators: name: Brown, Jeffrey M.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences

description: The vesicular monoamine transporter-2 (VMAT-2) is responsible for the sequestration of dopamine (DA) into synaptic vesicles and therefore may influence quantal release. Studies assessing whether pharmacological agents can regulate VMAT-2 acutely have yielded conflicting results. Hence, the purpose of the present studies was to determine if psychostimulant administration alters vesicular DA uptake.  Results presented demonstrate that multiple methamphetamine (METH) administrations produced rapid (within 1 h) and prolonged (i.e., up to 24 h) decreases in vesicular DA uptake and binding of the VMAT-2 ligand dihydrotetrabenazine (DHTBZ), as assessed in purified vesicles prepared from drug-treated rats. A single METH administration rapidly (within 1 h) but transiently (recovered by 24 h) decreased vesicular DA uptake an effect dependent on activation of D2 DA receptors.  In contrast to METH, administration of DA transporter inhibitors, including cocaine, increased both vesicular DA uptake and DHTBZ binding in purified vesicular preparations. The rapid (within 1 h) and reversible (within 6 h) increase induced by cocaine was dependent on D2 receptor activation. Activation of D2 receptors was also sufficient to increase vesicular DA uptake and DHTBZ binding.  These studies also examined a mechanism for these cocaine-induced increases, trafficking of synaptic vesicles that contain the VMAT-2.  Results demonstrate that a single administration of cocaine decreased VMAT-2 immunoreactivity associated with membrane-bound vesicles, but increased VMAT-2 immunoreactivity associated with the cytoplasmic pool of vesicles, the latter representing the pool of vesicles purified in the above-mentioned studies.  In conclusion, studies presented here suggest that vesicular DA uptake is regulated by drug treatments. Of relevance is the finding that multiple high-dose administrations of METH cause prolonged decreases in vesicular DA uptake and long-term damage to dopaminergic neurons. In contrast, cocaine, which increases vesicular DA uptake, does not cause long-term damage to dopamine neurons. Therefore, prolonged inhibition of VMAT-2 may contribute to drug-induced cell damage. Hence, regulation of VMAT-2 activity may have implications in addition to regulation of quantal DA release. Further studies examining regulation of this transporter are warranted.
Sonnenfleckenzeichnung Nr. 22197.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.05.1966, erstellt von Berthold Hermes
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1966

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The origin of the graveyard headstone: some 17th-century examples in Bedfordshire
Creators: name: Mytum, Harold
name: Chapman, Kate
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 67-78
description: A group of headstones from Wrestlingworth and Potton, Bedfordshire, belong to the second half of the 17th century. They demonstrate the presence of skilled carvers creating external memorials in a range of styles that can be seen to develop over time, with seven distinct types identified at the two graveyards. The competence in carving, and the range of motifs and letter styles, indicates that external commemoration based around professional carvers was established in this region at least by the time of the Restoration. All the stones are decorated, and the earliest display contemporary domestic motifs. From the 1670s, mortality symbols are introduced, suggesting the application of appropriate symbolism to this type of commission. By the end of the 17th century a well-developed local style with mortality symbols in high relief can be identified, and at this time cherubs make their first appearance.
Iconographic representations of mortality and resurrection in 17th-century Gloucestershire
Creators: name: Owen, Kirsty
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 79-95
description: Research into the representation of death and resurrection on gravestones has given relatively little attention to the place of the death's head and cherub on English monuments in church and churchyard, with most enquiries focusing upon Scotland and New England. Gaps in the English evidence caused by decay and destruction have encouraged the imposition of a stylistic chronology established at a distance from the material under study. This paper considers the configuration of symbols of mortality and resurrection on the memorials of Gloucestershire. It seeks to uncover reasons for their use, interpreting each monument in terms of its individual design and positioning. It also challenges the established chronological progression from death's head to cherub and the presumption that images of mortality and resurrection were presented in deliberate contrast with each other.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.05.1966, erstellt von Vasile Dinulescu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1966

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Wren, Pearce, and St. Mary's: Ingestre parish church and its roofs
Creators: name: Meeson, Bob
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 97-112
description: This paper was prompted by a survey of the roofs over the nave, aisles and chancel before and during the recent restoration programme at St Mary's Church at Ingestre (Staffordshire). The project re-opened the question of who designed and built the church, and how the craftsmen involved could be secured to work on the building at a time when the Fire of London had created such a high demand for their skills in the capital. Commissioned by Walter Chetwynd, St Marys was built between 1672 and 1676. The circumstantial evidence that Sir Christopher Wren was the architect is discussed, along with the possibility that Edward Pearce might have been available to control the work on site, and this reflects some of the complexities of the mid-17th-century building industry. The roofs are described, with particular reference to the carpentry and metal fixings.
Archaeologists and human remains: policy and practice behind the latest guidelines
Creators: name: Taylor, Alison
Publisher: name: Archaeology Data Service
Year: 2020

description: Church Archaeology, 7-9, 115-119
description: Treatment of human remains is an emotive issue, as well as at times a complex legal, scientific and practical problem. New guidance on remains from Christian burial grounds (2005) by the Human Remain Working Group (HWRG) convened by the Church of England and English Heritage for remains dating between the seventh and the 19th centuries at last gives clear guidelines for hard-pressed clergy and archaeologists faced with providing appropriate treatment for the great number of human skeletons that come to light each year in this cultural group. These skeletons range from fragments disturbed during routine works in churchyards, to several thousand bodies at Spitalfields, and include sites such as monastic cemeteries lost after the Reformation which are not under Faculty jurisdiction. The aim of the working party was to combine ethical and Christian considerations with the ethics of science and archaeology, especially in the vexed question of reburial versus storage. Archaeologists take a great deal of responsibility for dealing with human remains, so it is important to have guidance and back up for the approaches we need to take, whether in the field, laboratory or the museum/ storage context. Technical issues and theological considerations were considered in detail. As Simon Mays outlined above, recommendations include provision of long-term storage in buildings such as redundant churches; this alone could resolve a lot of pressing problems.
Engineering factors relating to the production of smokeless fuel, oil and gas from Rocky Mountain coals, by low temperature carbonization
Creators: name: Carter, George W.
Publisher: name: University of Utah
Year: 2012
Subjects: Smoke prevention
Coal, carbonization

description: One-hundred and forty-eight human souls in the small town of Winter Quarters near Omaha, set out on April 7, 1847 to find a new place under the sun where there would be no religious persecution. On July 24th, one-hundred and nine days after the arduous trek was begun, this hardy band of Mormon pioneers stood at the mouth of Emigration canyon and heard their great leader, Brigham Young, say, "This is the right place, drive on." Of this historic incident, Orson Pratt wrote: "After traveling six miles through a deep ravine ending with the canyon, we came in full view of the valley of Great Salt Lake, "We gazed in wonder and admiration upon the vast valley before us, with the water of Great Salt Lake glistening in the sun, mountains towering to the skies, and streams of pure water running through the beautiful valley. It was the grandest view we had ever seen till this moment." And now, eight-seven years later, from the same place where Brigham Young uttered his famous words, one views a scene much changed. For a great part of the time one can not discern the beautiful handiwork wrought there by Mother Nature, for it is now obscured by the presence of a man-made, opaque blanket of smoke which completely covers the valley below. Alas, this picturesque locality, with its waters of Great Salt Lake that rarely glisten in the sun, is buried beneath that sea of smoke, its people living in an atmosphere polluted with soot and noxious vapors and robbed of a full proportion of the health-giving rays of the sun.
The study of a new antibiotic aztreonam in the treatment of pulmonary exacertations in cystic fibrosis patients
Creators: name: Benson, John Merlin
Publisher: name: University of Utah
Year: 2013

description: Cystic fibrosis is a genetically inherited disease that occurs in one out every 2000 live caucasian births, and is the most common lethal, genetic disease of caucasians. the inheritance of this disease appears to follow an autosomal recessive pattern, and approximately five percent of Americans are asymptomatic carriers of the cystic fibrosis gene. the majority of cystic fibrosis patients present with a triad of characteristic signs: obstructive pulmonary disease, pancreatic achylia, and increased sweat sodium chloride concentration. Pulmonary complications have accounted for as much as 90% of the mortality associated with cystic fibrosis, and recurrent pulmonary infections requiring hospitalizations continue to be the major cause of the morbidity, mortality, and expense that these patients and their families suffer. Pulmonary infections in cystic fibrosis patients are often cause by Staphylococcus aureus early in the disease, but as the disease progresses over time, most patients eventually become infected and/or colonized with Pseudomonas aeruginosa, a gram-negative microorganism with a known propensity for antimicrobial resistance.  Aztreonam is the first of a new class of beta-lactam antibiotics called monobactams. The monobactam antibiotics differ from other beta-lactam antibiotics in that they are completely synthetic in origin, and the beta-lactam ring is not fused to another ring system as in the penicillins and cephalosporins. The purpose of this study was to examine the efficacy of aztreonam in the treatment of gram-negative pneumonia in patients with cystic fibrosis. Aztreonam has been shown in preliminary studies to be effective in the treatment of Pseudomonas aeruginosa infections. A more effective antipseudomonal agent may help increase the life expectancy of cystic fibrosis patients, as well as help control the high health care costs these patient incur.