cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Constraining a Model of the Radio Sky Below 6 MHz Using the Parker Solar Probe/FIELDS Instrument in Preparation for Upcoming Lunar-based Experiments
Creators: name: Bassett, Neil
name: Rapetti, David
name: Nhan, Bang D.
name: Page, Brent
name: Burns, Jack O.
name: Pulupa, Marc
name: Bale, Stuart D.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a Bayesian analysis of data from the FIELDS instrument on board the Parker Solar Probe (PSP) spacecraft with the aim of constraining low frequency ($\lesssim$ 6 MHz) sky in preparation for several upcoming lunar-based experiments. We utilize data recorded during PSP's ``coning roll'' maneuvers, in which the axis of the spacecraft is pointed 45$^{\circ}$ off of the Sun. The spacecraft then rotates about a line between the Sun and the spacecraft with a period of 24 minutes. We reduce the data into two formats: roll-averaged, in which the spectra are averaged over the roll, and phase-binned, in which the spectra are binned according to the phase of the roll. We construct a forward model of the FIELDS observations that includes numerical simulations of the antenna beam, an analytic emissivity function of the galaxy, and estimates of the absorption due to free electrons. Fitting 5 parameters, we find that the roll-averaged data can be fit well by this model and we obtain posterior parameter constraints that are in general agreement with previous estimates. The model is not, however, able to fit the phase-binned data well, likely due to limitations such as the lack of non-smooth emission structure at both small and large scales, enforced symmetry between the northern and southern galactic hemispheres, and large uncertainties in the free electron density. This suggests that significant improvement in the low frequency sky model is needed in order to fully and accurately represent the sky at frequencies below 6 MHz.
description: 18 pages, 10 figures, 5 tables. Under review in the Astrophysical Journal
Raf-1 Serine 338 Phosphorylation Plays a Key Role in Adhesion-Dependent Activation of Extracellular Signal-Regulated Kinase by Epidermal Growth Factor
Creators: name: Edin, M. L.
name: Juliano, R. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Activation of the extracellular signal-regulated kinase (ERK) 1/2 cascade by polypeptide growth factors is tightly coupled to adhesion to extracellular matrix in nontransformed cells. Raf-1, the initial kinase in this cascade, is intricately regulated by phosphorylation, localization, and molecular interactions. We investigated the complex interactions between Raf-1, protein kinase A (PKA), and p21-activated kinase (PAK) to determine their roles in the adhesion dependence of signaling from epidermal growth factor (EGF) to ERK. We conclude that Raf-1 phosphorylation on serine 338 (S338) is a critical step that is inhibited in suspended cells. Restoration of phosphorylation at S338, either by expression of highly active PAK or by expression of an S338 phospho-mimetic Raf-1 mutation, led to a partial rescue of ERK activation in suspended cells. Raf-1 inhibition in suspension was not due to excessive negative regulation on inhibitory sites S43 and S259, as these serines were largely dephosphorylated in suspended cells. Finally, strong phosphorylation of Raf-1 S338 provided resistance to PKA-mediated inhibition of ERK activation. Phosphorylation at Raf-1 S43 and S259 by PKA only weakly inhibited EGF activation of Raf-1 and ERK when cells maintained high Raf-1 S338 phosphorylation.
Standing sausage modes in coronal loops with plasma flow
Creators: name: Li, Bo
name: Chen, Shao-Xia
name: Xia, Li-Dong
name: Yu, Hui
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Magnetohydrodynamic waves are important for diagnosing the physical parameters of coronal plasmas. Field-aligned flows appear frequently in coronal loops.We examine the effects of transverse density and plasma flow structuring on standing sausage modes trapped in coronal loops, and examine their observational implications. We model coronal loops as straight cold cylinders with plasma flow embedded in a static corona. An eigen-value problem governing propagating sausage waves is formulated, its solutions used to construct standing modes. Two transverse profiles are distinguished, one being the generalized Epstein distribution (profile E) and the other (N) proposed recently in Nakariakov et al.(2012). A parameter study is performed on the dependence of the maximum period $P_\mathrm{max}$ and cutoff length-to-radius ratio $(L/a)_{\mathrm{cutoff}}$ in the trapped regime on the density parameters ($ρ_0/ρ_\infty$ and profile steepness $p$) and flow parameters (magnitude $U_0$ and profile steepness $u$). For either profile, introducing a flow reduces $P_\mathrm{max}$ relative to the static case. $P_\mathrm{max}$ depends sensitively on $p$ for profile N but is insensitive to $p$ for profile E. By far the most important effect a flow introduces is to reduce the capability for loops to trap standing sausage modes: $(L/a)_{\mathrm{cutoff}}$ may be substantially reduced in the case with flow relative to the static one. If the density distribution can be described by profile N, then measuring the sausage mode period can help deduce the density profile steepness. However, this practice is not feasible if profile E better describes the density distribution. Furthermore, even field-aligned flows with magnitudes substantially smaller than the ambient Alfvén speed can make coronal loops considerably less likely to support trapped standing sausage modes.
description: 11 pages, 9 figures, to appear in Astronomy & Astrophysics
title: Stromatolitic microorganisms in and on top of fluid-escape structures of the 3.2 Ga Moodies Group
Creators: name: Reimann ,  Sebastian
name: Heubeck ,  Christoph
name: Homann ,  Martin
name: van Rensburg ,  Deon Johannes Janse
name: Wiedenbeck ,  Michael
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The global record of early life is only poorly preserved, but has an ark in the 3.2 Ga Moodies Group of the Barberton Greenstone Belt, South Africa and Eswatini. It preserves silicified photosynthetic and sulfate-reducing metabolic signatures in sandstone-dominated, terrestrial to shallow-marine strata. Large fluid-escape structures are common in thick-bedded kerogen-laminated sandstones of (sub-)tidal facies. We document and interpret silicified, massive and laminated carbonate aggregates and beds, both of likely microbial origin, within and on top of these syndepositional and early diagenetic features, not previously described from Archean shallow-water fluid-escape structures. We distinguish three morphotypes: (1) cm-scale, silicified, bulbous aggregates aligned within fluid-escape conduits; (2) up to dm-scale, dolomitized, finely-laminated conical and tabular mounds on top of the conduits; (3) cm-scale, isolated, silicified, finely-laminated, stromatolitic aggregates. In-situ SIMS isotope analyses from traverses across the best-preserved laminae of a mound yielded δ13C(PDB) values relative to a dolomite standard of -2.5 to 0.5‰, and -3.5 to 4.0‰ for δ34S(VCDT) from diagenetic rims of nearby detrital pyrite grains, respectively. Values and ranges are consistent with a near-complete hydrothermal alteration. Facies context, location within and on top of the fluid-escape structures, stromatolitic morphology, and carbonate composition suggest that robust microbial communities utilized one or several carbon-based redox pathways in this siliciclastic tidal setting. Methanogens, methanotrophs, sulfate reducers and photosynthesizers may have colonized these tidal-zone sand volcanoes at 3.2 Ga, collectively forming a diverse microbial community.
Localisation of gamma-ray bursts from the combined SpIRIT+HERMES-TP/SP nano-satellite constellation
Creators: name: Thomas, Matt
name: Trenti, Michele
name: Campana, Riccardo
name: Ghirlanda, Giancarlo
name: Ripa, Jakub
name: Burderi, Luciano
name: Fiore, Fabrizio
name: Evangelista, Yuri
name: Amati, Lorenzo
name: Barraclough, Simon
name: Auchettl, Katie
name: del Castillo, Miguel Ortiz
name: Chapman, Airlie
name: Citossi, Marco
name: Colagrossi, Andrea
name: Dilillo, Giuseppe
name: Deiosso, Nicola
name: Demenev, Evgeny
name: Longo, Francesco
name: Marino, Alessio
name: McRobbie, Jack
name: Mearns, Robert
name: Melandri, Andrea
name: Riggio, Alessandro
name: Di Salvo, Tiziana
name: Simonetta, Puccetti
name: Topinka, Martin
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Multi-messenger observations of the transient sky to detect cosmic explosions and counterparts of gravitational wave mergers critically rely on orbiting wide-FoV telescopes to cover the wide range of wavelengths where atmospheric absorption and emission limit the use of ground facilities. Thanks to continuing technological improvements, miniaturised space instruments operating as distributed-aperture constellations are offering new capabilities for the study of high energy transients to complement ageing existing satellites. In this paper we characterise the performance of the upcoming joint SpIRIT + HERMES-TP/SP nano-satellite constellation for the localisation of high-energy transients through triangulation of signal arrival times. SpIRIT is an Australian technology and science demonstrator satellite designed to operate in a low-Earth Sun-synchronous Polar orbit that will augment the science operations for the equatorial HERMES-TP/SP. In this work we simulate the improvement to the localisation capabilities of the HERMES-TP/SP when SpIRIT is included in an orbital plane nearly perpendicular (inclination = 97.6$^\circ$) to the HERMES orbits. For the fraction of GRBs detected by three of the HERMES satellites plus SpIRIT, the combined constellation is capable of localising 60% of long GRBs to within ~ 30 deg$^2$ on the sky, and 60% of short GRBs within ~ 1850 deg$^2$. Based purely on statistical GRB localisation capabilities (i.e., excluding systematic uncertainties and sky coverage), these figures for long GRBs are comparable to those reported by the Fermi GBM. Further improvements by a factor of 2 (or 4) can be achieved by launching an additional 4 (or 6) SpIRIT-like satellites into a Polar orbit, which would both increase the fraction of sky covered by multiple satellite elements, and enable $\geq$ 60% of long GRBs to be localised within a radius of ~ 1.5$^\circ$ on the sky.
description: 17 pages, 10 figures, 1 table. Accepted for publication in PASA
A Philosophical Defence of Thought Experiments in Political Philosophy
Creators: name: Mendie, Patrick Johnson
Publisher: name: Lancaster University
Year: 2023

description: This thesis provides a defence of thought experiments in political philosophy, also known as ‘political thought experiments’ (PTEs). Different problems cast doubt on whether PTEs can be considered as being trustworthy. Critics think that the use of unrealistic hypotheticals in PTEs is problematic, especially when scenarios are completely detached from ‘real’ and ‘recurring’ situations as they occur in the actual world. I resolve this problem using the reflective equilibrium method, demonstrating how we can establish the logical equivalence between the unrealistic scenarios and the real-world counterparts with which they can be compared to understand their real-world implications. I also argue that since PTEs are arguments, the use of unrealistic premises does not affect the validity of their arguments. Critics also think that PTEs yield varying responses from different readers, meaning their intuitions are neither stable nor objective. I respond to this concern using John Norton’s ‘ argument view’ which proposes the idea that scientific thought experiments are disguised arguments, consisting of tacit premises and conclusions. I extend this view to PTEs, arguing that some PTEs contain valid arguments ruled by a system of logical inference. I examine some examples of PTEs by reconstructing them as valid arguments, arguing that PTEs with valid arguments are capable of evoking stable and objective intuitions. Finally, I discuss the concern of whether PTEs can motivate readers, in particular, how PTEs can be used in responding to real-world dilemmas. I establish the relationship between PTEs and narratives arguing that PTEs with ‘narrative transport’ would reasonably motivate readers. Using the problem of corruption in Nigeria as a case study, I show how PTEs can provide action guidance in responding to the issues of corruption in Nigeria. In conclusion, the original contribution of this research lies in the defenceof PTEs, and the claim that PTEs can be useful in solving real-world dilemmas.
Recombination at Long Mutant Telomeres Produces Tiny Single- and Double-Stranded Telomeric Circles
Creators: name: Cesare, A. J.
name: Groff-Vindman, C.
name: Natarajan, S.
name: Griffith, J. D.
name: McEachern, M. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Recombinational telomere elongation (RTE) known as alternate lengthening of telomeres is the mechanism of telomere maintenance in up to 5 to 10% of human cancers. The telomeres of yeast mutants lacking telomerase can also be maintained by recombination. Previously, we proposed the roll-and-spread model to explain this elongation in the yeast Kluveromyces lactis. This model suggests that a very small (∼100-bp) circular molecule of telomeric DNA is copied by a rolling circle event to generate a single long telomere. The sequence of this primary elongated telomere is then spread by recombination to all remaining telomeres. Here we show by two-dimensional gel analysis and electron microscopy that small circles of single- and double-stranded telomeric DNA are commonly made by recombination in a K. lactis mutant with long telomeres. These circles were found to be especially abundant between 100 and 400 bp (or nucleotides). Interestingly, the single-stranded circles consist of only the G-rich telomeric strand sequence. To our knowledge this is the first report of single-stranded telomeric circles as a product of telomere dysfunction. We propose that the small telomeric circles form through the resolution of an intratelomeric strand invasion which resembles a t-loop. Our data reported here demonstrate that K. lactis can, in at least some circumstances, make telomeric circles of the very small sizes predicted by the roll-and-spread model. The very small circles seen here are both predicted products of telomere rapid deletion, a process observed in both human and yeast cells, and predicted templates for roll-and-spread RTE.
Building Ukrainian Current Research Information System (URIS)
Creators: name: Auhunas, Sabina
Publisher: name: Zenodo
Year: 2022
Subjects: CRIS
URIS
FAIR

description: Ukrainian Research Information System (URIS) is a web-based service that collects, manages, stores and analyzes information about research being carried out by Ukrainian universities and R&D organizations. The ultimate goal of the URIS is to enhance the location of information and experts on research and boost visibility of national research. In the future, the system will become a booking gate for technological services and research infrastructures and automation tool for key procedures within the scientific domain. Implementing CRIS will bring many benefits to the various set of stakeholders: it will help researchers with quicker access to information and lessen administrative burden, enable funders easily track the result and return on the work they have supported, assist businesses in finding a new perspective technologies, enhance decision-making process of officials and lastly, raise awareness among citizens in regard to national science. The system will contain information on publications, dissertations, patents, researchers, research organizations (their departments, units) and project descriptions. Furthermore, it will display multiple research metrics at the researcher, research group and institutional levels. The CRIS system will update regularly and link related research objects. https://nauka.gov.ua/en/
Inclusion of intersite spatial correlations in the alloy analogy approach to the half-filled ionic Hubbard model
Creators: name: Rowlands, D. A.
name: Zhang, Yu-Zhong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Using the nonlocal coherent-potential approximation we study the effect of intersite spatial correlations on the transition from band insulator to metal as well as from metal to Mott insulator in the "alloy analogy" approach to the paramagnetic solution of the half-filled ionic Hubbard model. We find that intersite spatial correlations enhance the metallic phase.
description: 18 pages, 7 figures
Translation Termination Is Involved in Histone mRNA Degradation when DNA Replication Is Inhibited
Creators: name: Kaygun, H.
name: Marzluff, W. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The levels of replication-dependent histone mRNAs are coordinately regulated with DNA synthesis. A major regulatory step in histone mRNA metabolism is regulation of the half-life of histone mRNAs. Replication-dependent histone mRNAs are the only metazoan mRNAs that are not polyadenylated. Instead, they end with a conserved stem-loop structure, which is recognized by the stem-loop binding protein (SLBP). SLBP is required for histone mRNA processing, as well as translation. We show here, using histone mRNAs whose translation can be regulated by the iron response element, that histone mRNAs need to be actively translated for their rapid degradation following the inhibition of DNA synthesis. We also demonstrate the requirement for translation using a mutant SLBP which is inactive in translation. Histone mRNAs are not rapidly degraded when DNA synthesis is inhibited or at the end of S phase in cells expressing this mutant SLBP. Replication-dependent histone mRNAs have very short 3′ untranslated regions, with the stem-loop located 30 to 70 nucleotides downstream of the translation termination codon. We show here that the stability of histone mRNAs can be modified by altering the position of the stem-loop, thereby changing the distance from the translation termination codon.
Numerical modeling of complex hydraulic fracture propagation in layered reservoirs with auto-optimization
Creators: name: Wang, Jiacheng
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Hydraulic fracturing
Optimization
Proppant transport
Natural-hydraulic fracture interaction

description: Hydraulic fracturing brings economic unconventional reservoir developments, and multi-cluster completion designs result in complex hydraulic fracture geometries. Therefore, accurate yet efficient modeling of the propagation of multiple non-planar hydraulic fractures is desired to study the mechanisms of hydraulic fracture propagation and optimize field completion designs. In this research, a novel hydraulic fracture model is developed to simulate the propagation of multiple hydraulic fractures with proppant transport in layered and naturally fractured reservoirs. The simplified three-dimensional displacement discontinuity method (S3D DDM) is enhanced to compute the hydraulic fracture deformation and propagation with analytical fracture height growth and vertical width variation. Using a single row of DDM elements, the enhanced S3D DDM hydraulic fracture model computes the fully 3D geometries with a similar computational intensity to a 2D model. Then an Eulerian-Lagrangian proppant transport model is developed, where the slurry flow rate and pressure are solved within the Eulerian regime, and the movement of solid proppant particles is solved within the Lagrangian regime. The adaptive proppant gridding scheme in the model allows a smaller grid size at the earlier fracturing stage for higher resolution and a larger grid size at the later fracturing stage for higher efficiency. Besides the physical model, an optimization module that utilizes advanced optimization algorithms such as genetic algorithm (GA) and pattern search algorithm (PSA) is proposed to automatically optimize the completion designs according to the preset targets. Numerical results show that hydraulic fracture propagation is under the combined influence of the in-situ stress, pumping schedule, natural fractures, and cluster placement. Hence, numerical simulation is needed to predict complex hydraulic fracture geometries under various geologic and completion settings. The complex hydraulic fracture geometries, together with fracturing fluid and proppant properties, also affect proppant placement. Moreover, the stress contrast at layer interfaces can cause proppant bridging and form barriers on the proppant transport path. The optimized completion designs increase effective hydraulic and propped areas, but they vary depending on the optimization targets. The developed hydraulic fracture model provides insights into the hydraulic fracturing process and benefits unconventional reservoir development.
Spectrum of the secondary component and new orbital elements of the massive triple star Delta Ori A
Creators: name: Oplištilová, A.
name: Mayer, P.
name: Harmanec, P.
name: Brož, M.
name: Pigulski, A.
name: Božić, H.
name: Zasche, P.
name: Šlechta, M.
name: Pablo, H.
name: Kołaczek-Szymański, P. A.
name: Moffat, A. F. J.
name: Lovekin, C. C.
name: Wade, G. A.
name: Zwintz, K.
name: Popowicz, A.
name: Weiss, W. W.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: $δ$ Orionis is the closest massive multiple stellar system and one of the brightest members of the Orion OB association. The primary (Aa1) is a unique evolved O star. In this work, we applied a two-step disentangling method to a series of spectra in the blue region (430 to 450 nm), and we detected spectral lines of the secondary (Aa2). For the first time, we were able to constrain the orbit of the tertiary (Ab) - to 55 450 d or 152 yr - using variable $γ$ velocities and new speckle interferometric measurements, which have been published in the Washington Double Star Catalogue. In addition, the Gaia DR3 parallax of the faint component (Ca+Cb) constrains the distance of the system to (381 $\pm$ 8) pc, which is just in the centre of the Orion OB1b association, at (382 $\pm$ 1) pc. Consequently, we found that the component masses according to the three-body model are 17.8, 8.5, and 8.7 M$_{\odot}$, for Aa1, Aa2, and Ab, respectively, with the uncertainties of the order of $1$ M$_{\odot}$. We used new photometry from the BRITE satellites together with astrometry, radial velocities, eclipse timings, eclipse duration, spectral line profiles, and spectral energy distribution to refine radiative properties. The components, classified as O9.5 II + B2 V + B0 IV, have radii of 13.1, 4.1, and 12.0 R$_{\odot}$, which means that $δ$ Ori A is a pre-mass-transfer object. The frequency of 0.478 cycles per day, known from the Fourier analysis of the residual light curve and X-ray observations, was identified as the rotation frequency of the tertiary. $δ$ Ori could be related to other bright stars in Orion, in particular, $ζ$ Ori, which has a similar architecture, or $\varepsilon$ Ori, which is a single supergiant, and possibly a post-mass-transfer object.
description: 22 pages, 22 figures
Possible Supersymmetric Kinematics
Creators: name: Huang, Chao-Guang
name: Li, Lin
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The contraction method in different limits to obtain 22 different realizations of kinematical algebras is applied to study the supersymmetric extension of \AdS\ algebra and its contractions. It is shown that $\frak{p}_2$ $\frak{h}_-$, $\frak{p}'$, $\frak{c}_2$ and $\frak{g}'$ algebras, in addition to $\frak{d}_-$, $\frak{p}$, $\frak{n}_-$, $\frak{g}$ and $\frak{c}$ algebras, have supersymmetric extension, while $\frak{n}_{-2}$, $\frak{g}_2$ and $\frak{g}'_2$ algebras have no supersymmetric extension. The connections among the superalgebras are established.
Xeroderma Pigmentosum Complementation Group E Protein (XPE/DDB2): Purification of Various Complexes of XPE and Analyses of Their Damaged DNA Binding and Putative DNA Repair Properties
Creators: name: Sancar, A.
name: Reardon, J. T.
name: Kulaksiz, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Xeroderma pigmentosum is characterized by increased sensitivity of the affected individuals to sunlight and light-induced skin cancers and, in some cases, to neurological abnormalities. The disease is caused by a mutation in genes XPA through XPG and the XP variant (XPV) gene. The proteins encoded by the XPA, -B, -C, -D, -F, and -G genes are required for nucleotide excision repair, and the XPV gene encodes DNA polymerase eta, which carries out translesion DNA synthesis. In contrast, the mechanism by which the XPE gene product prevents sunlight-induced cancers is not known. The gene (XPE/DDB2) encodes the small subunit of a heterodimeric DNA binding protein with high affinity to UV-damaged DNA (UV-damaged DNA binding protein [UV-DDB]). The DDB2 protein exists in at least four forms in the cell: monomeric DDB2, DDB1-DDB2 heterodimer (UV-DDB), and as a protein associated with both the Cullin 4A (CUL4A) complex and the COP9 signalosome. To better define the role of DDB2 in the cellular response to DNA damage, we purified all four forms of DDB2 and analyzed their DNA binding properties and their effects on mammalian nucleotide excision repair. We find that DDB2 has an intrinsic damaged DNA binding activity and that under our assay conditions neither DDB2 nor complexes that contain DDB2 (UV-DDB, CUL4A, and COP9) participate in nucleotide excision repair carried out by the six-factor human excision nuclease.
CIB1 Is Essential for Mouse Spermatogenesis
Creators: name: Parise, L. V.
name: Clark, S.
name: O'Brien, D. A.
name: Maeda, N.
name: McFadden, A. W.
name: Yuan, W.
name: Leisner, T. M.
name: Hiller, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: CIB1 is a 22-kDa calcium binding, regulatory protein with ∼50% homology to calmodulin and calcineurin B. CIB1 is widely expressed and binds to a number of effectors, such as integrin αIIb, PAK1, and polo-like kinases, in different tissues. However, the in vivo functions of CIB1 are not well understood. To elucidate the function of CIB1 in whole animals, we used homologous recombination in embryonic stem cells to generate Cib1−/− mice. Although Cib1−/− mice grow normally, the males are sterile due to disruption of the haploid phase of spermatogenesis. This is associated with reduced testis size and numbers of germ cells in seminiferous tubules, increased germ cell apoptosis, and the loss of elongated spermatids and sperm. Cib1−/− testes also show increased mRNA and protein expression of the cell cycle regulator Cdc2/Cdk1. In addition, mouse embryonic fibroblasts (MEFs) derived from Cib1−/− mice exhibit a much slower growth rate compared to Cib1+/+ MEFs, suggesting that CIB1 regulates the cell cycle, differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Spettacolo fondato su tecniche e competenze plurime, la Commedia dell’Arte deve gran parte della sua fortuna anche grazie al suo mito figurativo, sedimentatosi in tutta Europa dalla fine del ‘500 a tutto il ‘700, in parallelo all’affermarsi e al diffondersi della forma spettacolare. Le immagini dedicate alla Commedia dell’Arte costituiscono quindi una fonte di primaria importanza, sia in quanto testimonianza di scambi di pratiche spettacolari tra differenti contesti produttivi – esemplare il caso dell’universo spettacolare gravitante attorno all’Ancien Théâtre Italien, alla seconda Comédie-Italienne e ai teatri delle fiere parigine di Saint-Germain e Saint-Laurent – sia per le modalità di diffusione di pratiche performative e modelli figurativi, rintracciabili nel duplice fenomeno delle persistenze sceniche e delle persistenze iconografiche.
description: A spectacle based on techniques and multiple skills, the Commedia dell'Arte owes a large part of its fortune also thanks to its figurative myth, which sedimented throughout Europe from the end of the sixteenth century to the whole of the eighteenth century, in parallel with the affirmation and development of the spectacular form. The images dedicated to the Commedia dell'Arte therefore constitute a source of primary importance, both as evidence of exchanges of spectacular practices between different production contexts - exemplary is the case of the spectacular universe gravitating around the Ancien Théâtre Italien, the second Comédie-Italienne and to the theaters of the Parisian fairs of Saint-Germain and Saint-Laurent - both for the methods of diffusion of performative practices and figurative models, traceable in the double phenomenon of scenic and iconographic persistences.
Clathrin Adaptor AP2 Regulates Thrombin Receptor Constitutive Internalization and Endothelial Cell Resensitization
Creators: name: Siderovski, D. P.
name: Trejo, J.
name: Paing, M. M.
name: Johnston, C. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Protease-activated receptor 1 (PAR1), a G protein-coupled receptor for the coagulant protease thrombin, is irreversibly activated by proteolysis. Unactivated PAR1 cycles constitutively between the plasma membrane and intracellular stores, thereby providing a protected receptor pool that replenishes the cell surface after thrombin exposure and leads to rapid resensitization to thrombin signaling independent of de novo receptor synthesis. Here, we show that AP2, a clathrin adaptor, binds directly to a tyrosine-based motif in the cytoplasmic tail of PAR1 and is essential for constitutive receptor internalization and cellular recovery of thrombin signaling. Expression of a PAR1 tyrosine mutant or depletion of AP2 by RNA interference leads to significant inhibition of PAR1 constitutive internalization, loss of intracellular uncleaved PAR1, and failure of endothelial cells and other cell types to regain thrombin responsiveness. Our findings establish a novel role for AP2 in direct regulation of PAR1 trafficking, a process critically important to the temporal and spatial aspects of thrombin signaling.
Stablizing oscillating universes against quantum decay
Creators: name: Mithani, Audrey T.
name: Vilenkin, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the effect of vacuum corrections, due to the trace anomaly and Casimir effect, on the stability of an oscillating universe with respect to decay by tunneling to the singularity. We find that these corrections do not generally stabilize an oscillating universe. However, stability may be achieved for some specially fine-tuned non-vacuum states.
description: 15 pages, 3 figures
Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65
Creators: name: Howell, M.
name: Stonebraker, J. R.
name: Teed, J.
name: Magnuson, T. R.
name: Boone, B. N.
name: O'Neal, W.
name: Morin-Kensicki, E. M.
name: Milgram, S. L.
name: Alb, J. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: YAP is a multifunctional adapter protein and transcriptional coactivator with several binding partners well described in vitro and in cell culture. To explore in vivo requirements for YAP, we generated mice carrying a targeted disruption of the Yap gene. Homozygosity for the Yaptm1Smil allele (Yap−/−) caused developmental arrest around E8.5. Phenotypic characterization revealed a requirement for YAP in yolk sac vasculogenesis. Yolk sac endothelial and erythrocyte precursors were specified as shown by histology, PECAM1 immunostaining, and alpha globin expression. Nonetheless, development of an organized yolk sac vascular plexus failed in Yap−/− embryos. In striking contrast, vasculogenesis proceeded in both the allantois and the embryo proper. Mutant embryos showed patterned gene expression domains along the anteroposterior neuraxis, midline, and streak/tailbud. Despite this evidence of proper patterning and tissue specification, Yap−/− embryos showed developmental perturbations that included a notably shortened body axis, convoluted anterior neuroepithelium, caudal dysgenesis, and failure of chorioallantoic fusion. These results reveal a vital requirement for YAP in the developmental processes of yolk sac vasculogenesis, chorioallantoic attachment, and embryonic axis elongation.
Update of the INTEGRAL/IBIS AGN catalogue: deeper on the Galactic plane and wider beyond
Creators: name: Malizia, A.
name: Bassani, L.
name: Landi, R.
name: Molina, M.
name: Masetti, N.
name: Palazzi, E.
name: Bruni, G.
name: Bazzano, A.
name: Ubertini, P.
name: Bird, A. J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this work we have updated the list of AGN detected by INTEGRAL taking into account the new objects listed in the last published INTEGRAL/IBIS survey. We have collected 83 new AGN increasing the number of INTEGRAL detected active galaxies (436) by 19%. Half of these new additions are located behind the Galactic plane; for most of them we have full X-ray coverage obtained through archival data from Swift/XRT, XMM-Newton and NuSTAR. This allowed us to associate each high-energy emitter with a single or multiple X-ray counterpart/s and characterise the spectral shape of these new AGN by estimating the photon index, the intrinsic absorption and the 2-10 keV flux. A few cases where two soft X-ray counterparts fall within the INTEGRAL error circle and at least one is classified as an AGN have been found and discussed in detail. Thirty-four sources originally listed as AGN candidates or unidentified objects have been recognised as AGN by employing three diagnostic tests: WISE colours, radio emission and morphology. For 12 sources, among the 34 AGN candidates, we reduced optical spectra and confirmed their AGN nature, providing also their optical class and redshift. This paper is part of an on-going effort to keep the INTEGRAL AGN catalogue updated in order to provide the scientific community with a hard X-ray selected sample of active galaxies well classified and spectrally characterised.
description: 18 pages, 13 figures. Accepted for publication in Astronomy & Astrophysics
Inverse Obstacle scattering in two dimensions with multiple frequency data and multiple angles of incidence
Creators: name: Borges, Carlos
name: Greengard, Leslie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: Mathematical Physics (math-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35R30 49N45

description: We consider the problem of reconstructing the shape of an impenetrable sound-soft obstacle from scattering measurements. The input data is assumed to be the far-field pattern generated when a plane wave impinges on an unknown obstacle from one or more directions and at one or more frequencies. It is well known that this inverse scattering problem is both ill posed and nonlinear. It is common practice to overcome the ill posedness through the use of a penalty method or Tikhonov regularization. Here, we present a more physical regularization, based simply on restricting the unknown boundary to be band-limited in a suitable sense. To overcome the nonlinearity of the problem, we use a variant of Newton's method. When multiple frequency data is available, we supplement Newton's method with the recursive linearization approach due to Chen. During the course of solving the inverse problem, we need to compute the solution to a large number of forward scattering problems. For this, we use high-order accurate integral equation discretizations, coupled with fast direct solvers when the problem is sufficiently large.
description: 20 pages, 1 table, 16 figures
Innovation models in value-based health care
Creators: name: Huang, Jingyao
name: 0000-0002-7607-9590
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Value-based health care
Payment innovation

description: The dissertation is composed of three essays and investigates two innovative models in the value-based health care: 1) Integrated Practice Unit, and 2) the Benefits-Value-Advisor program. The first essay focuses on Integrated Practice Unit (IPU), which is a recently proposed form of care delivery model, where a multi-disciplinary team of providers collaborates to cover full care cycle for patients with a particular medical condition. To address the imbalanced resource utilization issue faced by many IPUs and similar applications, we combine coordinated services and virtual medicine to study a coordinated scheduling problem with both virtual medicine patients (VM patients) and in-clinic patients (IC patients) in a multi-disciplinary setting. We developed a stochastic optimization model and utilized discrete convexity to develop an efficient scheduling approach, which significantly improved system utilization and profit without a large increase in the waiting time and overtime. The other two essays focus on the Benefits-Value-Advisor (BVA) program, which is a recently proposed payment innovation. Large price variation is prevalent for non-urgent and routine medical procedures such as MRI and CT Scan, which has led some insurers to introduce the BVA program to steer beneficiaries to low-cost providers. We explored the impact of the BVA program in two aspects. For beneficiaries, we developed a behavioral experiment to investigate which strategy employed by the BVA program is the most effective on steering beneficiaries' choices. For providers, we constructed a game-theoretic model to explore the providers' price responses, and the question that under which conditions the program leads to cost savings for insurers. We find that providers have heterogeneous price behaviors depending on provider types. Additionally, the BVA program does not save expenditures in all the cases. The performance of the BVA program in cost savings depends on market characteristics.
MPEC 2024-R359 : 2024 RD32
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RD32

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Distinct Action of the Retinoblastoma Pathway on the DNA Replication Machinery Defines Specific Roles for Cyclin-Dependent Kinase Complexes in Prereplication Complex Assembly and S-Phase Progression
Creators: name: Braden, W. A.
name: Zagorski, W.
name: Cook, J. G.
name: Bosco, E.
name: Lenihan, J. M.
name: Lan, Z.
name: Knudsen, E. S.
name: Reed, M. F.
name: Luce, K. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The retinoblastoma (RB) and p16ink4a tumor suppressors are believed to function in a linear pathway that is functionally inactivated in a large fraction of human cancers. Recent studies have shown that RB plays a critical role in regulating S phase as a means for suppressing aberrant proliferation and controlling genome stability. Here, we demonstrate a novel role for p16ink4a in replication control that is distinct from that of RB. Specifically, p16ink4a disrupts prereplication complex assembly by inhibiting mini-chromosome maintenance (MCM) protein loading in G1, while RB was found to disrupt replication in S phase through attenuation of PCNA function. This influence of p16ink4a on the prereplication complex was dependent on the presence of RB and the downregulation of cyclin-dependent kinase (CDK) activity. Strikingly, the inhibition of CDK2 activity was not sufficient to prevent the loading of MCM proteins onto chromatin, which supports a model wherein the composite action of multiple G1 CDK complexes regulates prereplication complex assembly. Additionally, p16ink4a attenuated the levels of the assembly factors Cdt1 and Cdc6. The enforced expression of these two licensing factors was sufficient to restore the assembly of the prereplication complex yet failed to promote S-phase progression due to the continued absence of PCNA function. Combined, these data reveal that RB and p16ink4a function through distinct pathways to inhibit the replication machinery and provide evidence that stepwise regulation of CDK activity interfaces with the replication machinery at two discrete execution points.
title: Youth engagement and participation in a child and youth care context
Creators: name: Sinclair, Lindsay
name: Vieira, Melissa
name: Zufelt, Vanessa
Publisher: name: Strathprints - University of Strathclyde
Year: 2019

description: Youth participation and engagement were examined and reviewed using three core Child and Youth Care (CYC) contexts: engagement, relationships and self. It was found that meaningful youth participation occurred when a tangible change process followed young people’s engagement with adults. Different types of youth participation were reviewed. The research revealed several barriers to meaningful youth engagement, such as tokenism, social power imbalances, and biases on the part of both the young people and the practitioners. Young people in care, in particular, face barriers to youth engagement. Positive youth engagement is achieved when young people are seen as experts in their own lives and are engaged as primary stakeholders in their own plan-of-care meetings. This process can be augmented by the presence of youth engagement facilitators, which CYC practitioners are ideally suited to be. Critical self-reflection can help practitioners become aware of their own definitions of and biases towards youth engagement. Given that there is no one agreed upon definition of youth engagement, it differs between individuals and organisations. Youth are often engaged following the completion of a programme. Scholars purport that youth should be engaged in the planning, creation and final evaluation stages of programme administration.
The Frobenius anatomy of word meanings II: possessive relative pronouns
Creators: name: Sadrzadeh, Mehrnoosh
name: Clark, Stephen
name: Coecke, Bob
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: Category Theory (math.CT)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: I.2.7; F.4.1
subject: 18Dxx, 18Axx

description: Within the categorical compositional distributional model of meaning, we provide semantic interpretations for the subject and object roles of the possessive relative pronoun `whose'. This is done in terms of Frobenius algebras over compact closed categories. These algebras and their diagrammatic language expose how meanings of words in relative clauses interact with each other. We show how our interpretation is related to Montague-style semantics and provide a truth-theoretic interpretation. We also show how vector spaces provide a concrete interpretation and provide preliminary corpus-based experimental evidence. In a prequel to this paper, we used similar methods and dealt with the case of subject and object relative pronouns.
description: 40 pages, Journal of Logic and Computation, Essays dedicated to Roy Dyckhoff on the occasion of his retirement, S. Graham-Lengrand and D. Galmiche (eds.), 2014
Study of strong photon-magnon coupling in a YIG-film split-ring resonant system
Creators: name: Bhoi, B.
name: Cliff, T.
name: Maksymov, I. S.
name: Kostylev, M.
name: Aiyar, R.
name: Venkataramani, N.
name: Prasad, S.
name: Stamps, R. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: By using the stripline Microwave Vector Network Analyzer Ferromagnetic Resonance and Pulsed Inductive Microwave Magnetometry spectroscopy techniques, we study a strong coupling regime of magnons to microwave photons in the planar geometry of a lithographically formed split-ring resonator (SRR) loaded by a single-crystal epitaxial yttrium-iron garnet (YIG) film. Strong anti-crossing of the photon modes of SRR and of the magnon modes of the YIG film is observed in the applied-magnetic-field resolved measurements. The coupling strength extracted from the experimental data reaches 9 percent at 3 GHz. Theoretically, we propose an equivalent circuit model of an SRR loaded by a magnetic film. This model follows from the results of our numerical simulations of the microwave field structure of the SRR and of the magnetization dynamics in the YIG film driven by the microwave currents in the SRR. The equivalent circuit model is in good agreement with the experiment. It provides a simple physical explanation of the process of mode anti-crossing. Our findings are important for future applications in microwave quantum photonic devices as well as in magnetically tunable metamaterials exploiting the strong coupling of magnons to microwave photons.
dysfusion Transcriptional Control of Drosophila Tracheal Migration, Adhesion, and Fusion
Creators: name: Jiang, L.
name: Crews, S. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The Drosophila dysfusion basic-helix-loop-helix-PAS transcription factor gene is expressed in specialized fusion cells that reside at the tips of migrating tracheal branches. dysfusion mutants were isolated, and genetic analysis of live embryos revealed that mutant tracheal branches migrate to close proximity but fail to recognize and adhere to each other. Misexpression of dysfusion throughout the trachea further indicated that dysfusion has the ability to both inhibit cell migration and promote ectopic tracheal fusion. Nineteen genes whose expression either increases or decreases in fusion cells during development were analyzed in dysfusion mutant embryos. dysfusion upregulates the levels of four genes, including the shotgun cell adhesion protein gene and the zona pellucida family transmembrane protein gene, CG13196. Misexpression experiments with CG13196 result in ectopic tracheal fusion events, suggesting that it also encodes a cell adhesion protein. Another target gene of dysfusion is members only, which inhibits protein nuclear export and influences tracheal fusion. dysfusion also indirectly downregulates protein levels of Trachealess, an important regulator of tracheal development. These results indicate that fusion cells undergo dynamic changes in gene expression as they switch from migratory to fusion modes and that dysfusion regulates a discrete, but important, set of these genes.