cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pompton Lake and Ramapo River TMDL Support Study
Creators: name: No Name Supplied
Publisher: name: Quantitative Environmental Analysis, LLC
Year: 2005

description: This study was undertaken to support New Jersey Department of Environmental Protection's (NJDEP) total maximum daily load (TMDL) and watershed restoration efforts  within the Passaic River Basin. Its goal was to assess the water quality of the Pompton Lake-Ramapo River system to support decisions regarding lake restoration. There were four main objectives: (1) Evaluate existing data to characterize water quality impairments, if any, to Pompton Lake; (2) Apply existing information to quantify phosphorus loads to Pompton Lake; (3) Determine whether an empirical relationship can be established for in-lake phosphorus; concentration and influent phosphorus loads; and (4) Identify data and research gaps that need to be addressed in order to develop a lake restoration plan.
Chorthippus vagans
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Chorthippus
Chorthippus vagans

description: 34. Chorthippus vagans (Eversmann, 1848) = velikouhi livadni skakavac
34.1. Chorthippus vagans vagans (Eversmann, 1848)
First faunistic record for Croatia: Frauenfeld 1861
Distribution in Croatia: Nominal subspecies only. Rare, known from a few records from most of the regions, but the majority of the records have not been confirmed for more than 50 years. Pannonian region (mostly old records—Graber 1870 and Pungur 1899; new record Mura-Drava Regional Park: Rebrina and BIUS, Section of Orthopterology 1.-5.VIII.2016), the Dinaric Alps (Dinara—Rebrina et al. 2015, new data), Istria (old record only—Redtenbacher 1900), Kvarner (old record only—Krauss 1879), Adriatic Islands (old record only—Us 1964), and Dubrovnik region (old record only—Frauenfeld 1861). Not recorded from Dalmatia.
Distribution in Europe: Widespread from the Iberian Peninsula, Southern Italy and Cyprus (southern distribution border) to South England, Denmark and Northern Poland (northern border) and Siberia (eastern border) (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 55, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
2006 Delaware Estuary Water Education Resource Guide, 3rd Edition
Creators: name: No Name Supplied
Publisher: name: Philadelphia Water Department
Year: 2006

description: This is a directory for educators that lists materials and programs available through local non-profit organizations and agencies on topics relating to water resources in the Delaware Estuary region and beyond.  It is organized alphabetically and, in addition to contact data for each organization, provides information such as mission, materials available, and programs offered.  There is also a form at the back of the book to let the publishers know about other organizations and agencies that offer water-related educational programs.
Carcharhinus brevipinna
Creators: name: Golani, Daniel
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Carcharhinus
Carcharhinus brevipinna

description: Carcharhinus brevipinna (Müller & Henle, 1841)
Carcharhinus brevipinna: Ben-Tuvia, 1966; Ben-Tuvia, 1971a; Ben-Tuvia, 1978; Golani, 1996; Golani, 2005; Golani, 2006.
description: Published as part of Golani, Daniel, 2021, An updated Checklist of the Mediterranean fishes of Israel, with illustrations of recently recorded species and delineation of Lessepsian migrants, pp. 1-108 in Zootaxa 4956 (1) on page 7, DOI: 10.11646/zootaxa.4956.1.1, http://zenodo.org/record/4691195
New Jersey Discharger: A Newsletter About New Jersey's Water Quality Programs, Vol. 12, No. 3, Winter 2004
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Division of Water Quality
Year: 2004

description: The New Jersey Discharger is intended to inform interested individuals about New Jersey's Water Quality Programs.  This issue includes articles titled: Environmental Infrastructure Financing Programs Funds 58 Projects in 2004 (includes a list of the projects); Rahway River and Arthur Kill to Get Water Quality Boost; New Jersey's Management Alternatives for Fat, Oils, and Grease in Short Supply; and Final General NJPDES Permit Issued for Residuals Transfer Facilities.
New Jersey Floodplain News, Issue 3
Creators: name: No Name Supplied
Publisher: name: New Jersey Association for Floodplain Management
Year: 2008

description: New Jersey Floodplain News, which is published bi-annually, is the newsletter for the New Jersey Association for Floodplain Management (NJAFM). The newsletter provides information on flooding, while advocating sound floodplain management in New Jersey. Highlights in this issue include: a report on FEMA's Severe Repetitive Loss (SRL) grant Program; the NJAFM 2007 Annual Conference report; an article on the Workshop on Future Priorities for the U.S. Climate Change Science Program; a summary of the "Chronic risks of Global Climate Change to Urban Coasts and Economies" symposium; the new Flood Hazard Area Control Act rules; and an article on flood resilience in 1955 and today.
An actionable genomics platform for PDAC targeted therapy using FDA approved drugs
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic ductal adenocarcinoma (PDAC); Actionable gene (AG); Synthetic promoter (SP); Synthetic promoters of the actionable gene (AGSP); RNA Sequencing (RNA-Seq); Weighted gene co-expression network analysis (WGCNA); High-throughput small molecule screening (HTS)
Ichneumon virulentus Smith 1874
Creators: name: Shimizu, So
name: Broad, Gavin R.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Ichneumon
Ichneumon virulentus

description: Ichneumon virulentus Smith, 1874
(Figure 22)
Taxonomic history. Heinrich (1937) transferred this species to Melanichneumon.
Current taxonomy. Melanichneumon virulentus (Smith, 1874) (Ichneumonidae: Ichneumoninae: Ichneumonini).
Type number. Type 3b.258. Specimen # NHMUK010881021
Type status. Holotype.
Sex. Female.
Type locality. Hyôgo Prefecture, Honshû, Japan.
Label data. First label, ‘ Type /C.M.’ (round label, with red margin; first line printed and second line handwriting); second label, ‘B.M. TYPE /HYM./3.b.258’ (square label; first and second lines printed and third line handwriting); third label, ‘B.M. TYPE /HYM./ Ichneumon /virulentus/ Smith 1874 ’ (square label; first and second lines printed and third to fifth lines handwriting); fourth label, ‘Hiogo/ Japan.’ (square label; first line handwriting and second line printed); fifth label, ‘74/16’ (round label; handwriting); sixth label, ‘ I. virulentus / Type. Smith.’ (square label; handwriting).
Condition. Very good, but the second to fifth tarsomeres of the right mid leg are lost.
description: Published as part of Shimizu, So & Broad, Gavin R., 2020, Photographic catalogue of the oldest primary types of Japanese Ichneumonoidea (Hymenoptera), those described by Frederick Smith and Francis Walker in 1874, pp. 1115-1198 in Journal of Natural History 54 (17) on page 1149, DOI: 10.1080/00222933.2020.1776905, http://zenodo.org/record/4116141
Known Contaminated Sites in New Jersey, Sixth Edition (2005)
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Site Remediation and Waste Management (SRWM)
Year: 2005

description: This is the 2005 edition of the Known Contaminated Sites in New Jersey report, which provides a list of sites where contamination of soil or ground water has been confirmed. The sites are grouped by municipality to make locating the sites of interest easier. Sites with a confirmed on-site  source(s) of contamination, as well as some sites where the source(s) of contamination is unknown, are included in the list. In addition, the report lists sites where the completed remediation requires engineering and/or institutional controls. These controls involve the placement of physical barriers or limiting activities that can be conducted at a site as a means of preventing exposure. Some engineering and/or institutional controls include maintenance and/or monitoring activity.
Known Contaminated Sites in New Jersey, Seventh Edition (Spring 2006)
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Site Remediation and Waste Management (SRWM)
Year: 2006

description: This is the 2006 edition of the Known Contaminated Sites in New Jersey report.  The report contains basic information on approximately 14,000 sites where contaminated soil and/or ground water has been confirmed. The sites are grouped by municipality to make locating the sites of interest easier. Sites with a confirmed on-site source(s) of contamination, as well as some sites where the source(s) of contamination is unknown, are included in the list. In addition, the report lists sites where the completed remediation requires engineering and/or institutional controls. Engineering controls involve the placement of physical barriers as a means of preventing exposure, such as placement of a cap. Institutional controls involve formal documentation of steps that must be taken to ensure the contamination is contained, such as  maintenance and/or monitoring activity. An Institutional control can also place limits on the future use of a  site, such as a deed notice.
New Jersey Greenhouse Gas Emissions
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP)
Year: 2007

description: This brief report shows the tons of greenhouse gas emitted in NJ in 1990, 2004, and 2020 (projected value if no reduction actions are taken). The projected figures up to 2050 are then compared to caps required by the Global Warming Response Act as well as other reduction targets.  Finally, the report lists some of the programs that NJ will use to meet greenhouse gas emission reduction goals.
Chrysochraon dispar
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Chrysochraon
Chrysochraon dispar

description: 35. Chrysochraon dispar (Germar, 1834) = veliki zlatni skakavac (Fig. 8A)
First faunistic record for Croatia: Us 1938 [without subspecies designation]
Distribution in Croatia [of both 35.1 and 35.2]: Present in the Pannonian region, Dinaric Alps and Istria, localized. Subspecies hitherto known from Croatia: C. d. dispar, C. d. giganteus Harz, 1975. The latter is known from a single record in Istria (Ingrisch 1981), but in other regions of the country the authors did not specify the subspecies. Hence, it is necessary to test the presence of C. d. giganteus in the rest of the country. Presence of C. d. dispar is hitherto confirmed in Žumberak (Nagy 2006) and Papuk Mt. (Szövenyi & Puskás 2012). After the comparison of the material from Serbia, Croatia, Italy, Slovenia and Macedonia, we found that the subspecies described from Bosnia by Mikšić— C. d. intermedius Mikšić, 1978 syn. nov. is synonymous with C. d. giganteus, because it fits the variability range of the latter. Statuses of the nominal subspecies and of C. d. giganteus are unclear and need to be resolved.
Distribution in Europe: Widely distributed from the Spanish Pyrenees, Northern Italy and Northeastern Greece (southern distribution border) to Northern Sweden (northern border) and Eastern European Russia (eastern border) (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 55, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Intersection of NF-kB and fibroblast growth factor receptor signaling pathways
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project is based upon our preliminary data that members of the FGFR family directly interact with an important regulator of NF-??B signaling, namely, the protein kinase IKK??. During a two-hybrid screen using FGFR4 as the bait protein, we identified IKK?? as a bona fide interacting protein. We have now established that FGFR4 and FGFR2 both interact with IKK?? by coimmunoprecipitation, and that FGFR2 activation results in strong tyrosine phosphorylation of IKK?? in cells. We will examine whether FGFR2 phosphorylates IKK?? on either or both Tyr188/Tyr199, within the activation loop of IKK??, establishing a direct link between FGFR signaling and NF-??B signaling. We will further characterize the interaction of FGFRs with IKK?? and/or IKK?? using two hybrid interactions, in vitro binding assays, and in vivo coimmunoprecipitations. We believe that the convergence of NF-??B signaling pathways with FGFR signaling pathways will represent a significant breakthrough in our understanding of FGFR3 activation in some human cancers such as multiple myeloma.
New Jersey's Response to Climate Change
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP)
Year: 2007

description: This presentation was given by Lisa P. Jackson (Commissioner of NJDEP) on March 30, 2007 as a description of New Jersey's response to climate change.  It discusses the effects of climate change on NJ, the state of NJ's greenhouse gas emissions, and NJ's strategy for dealing with this issue.  The strategy includes ongoing collaboration with other northeastern states as part of the Regional Greenhouse Gas Initiative (RGGI) and the Energy Master Plan - a plan to reduce energy use by 20% by 2020 and meet 20% of NJ's electricity needs through renewable sources.
Carcharhinus limbatus
Creators: name: Golani, Daniel
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Carcharhinus
Carcharhinus limbatus

description: Carcharhinus limbatus (Valenciennes, 1839)
Carcharhinus limbatus: Ben-Tuvia, 1953a; Ben-Tuvia, 1971a; Golani, 1996; Golani, 2005; Golani, 2006.
description: Published as part of Golani, Daniel, 2021, An updated Checklist of the Mediterranean fishes of Israel, with illustrations of recently recorded species and delineation of Lessepsian migrants, pp. 1-108 in Zootaxa 4956 (1) on page 7, DOI: 10.11646/zootaxa.4956.1.1, http://zenodo.org/record/4691195
Novel function of GCN5 in ubiquitination of MYC
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The MYC oncoprotein is a DNA-binding transcription factor that is overexpressed in most types of cancer. MYC regulates a large fraction of the genome and its transcription activity is required for its oncogenic function. The molecular mechanisms involved in regulation of MYC-dependent transcription are still poorly understood. MYC recruits a variety of histone acetyltransferases (HATs), including GCN5, p300/CBP, TIP60, other coactivators, and elongation factors to activate genes at the level of transcription initiation and elongation. In addition these HATs also acetylate MYC itself. Although the role of MYC acetylation is largely unclear, MYC acetylation by GCN5 increases its stability. Recently, ubiquitin modification and proteasomal degradation of MYC have been reported to be critical for MYC induction of histone acetylation, and activation of RNA polymerase II transcription elongation of most MYC target genes via still unknown ubiquitin E3-ligase enzymes. Although several ubiquitin E3 ligases can modify MYC and either activate or attenuate MYC-dependent transcription, it has been difficult to assign direct causative roles in MYC regulation due to their multiple other substrates. In addition, when tested, these individual ligases (e.g., SKP2) affect only a limited number of MYC target genes. This suggests the existence of additional MYC-modifying E3 ligases. Recently, we have obtained evidence that the GCN5 HAT strongly stimulates ubiquitination of the MYC oncoprotein in mammalian cells. Here we propose to characterize this novel catalytic function associated with GCN5 and its role in MYC regulation. The specific goals of the project are: (1) To identify the domain(s) of GCN5 responsible for MYC ubiquitination in cultured cells and characterize the type of ubiquitin chain linkage involved (e.g., Ub-K48 or -K63); (2) To determine whether GCN5 has an intrinsic E3 ligase activity that directly ubiquitinates MYC, or whether GCN5 associates with an E3 ligase in a complex; and (3) To define the role of GCN5-dependent ubiquitination in regulation of MYC. This project will uncover a novel pathway for MYC ubiquitination involving the GCN5 HAT and provide the first insight into how transcription activation by MYC is connected to its turnover by the proteasome, which is of high relevance to the cancer problem.
ZARAFSHON VODIYSIDA MINGLAR URUG'INING JOYLASHUVI.
Creators: name: Xursanov, Abdulvohid
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada Zarafshon vodiysining geografik joylashuvi uning tarixi hamda Minglar sulalolasining Zarafshon vodiysidagi o’rni va ahamiyati haqida ayrim ma’lumotlardan tashkil topgan. Xususan, bunda, minglar sulolasi davrida vodiydagi siyosat, madaniy hayot va ijtimoiy hamda iqtisodiy ‘zgarishlar haqida bir qancha fikrlar yuritiladi. Shuningdek, sulolaning ko’zga ko’ringan vakillari va ularning Zarafshon vodiysi tarixida tutgan o’rni va bu kunga qadar kimlar bu mavzuga doir izlanishlar olib borganligi to’g’risidagi ma’lumotlarni ham tahlil qilib beradi.
New Jersey: Planning and Action for a Low Carbon Future
Creators: name: No Name Supplied
Publisher: name: The Center for Climate Strategies
Year: 2007

description: This presentation was given at the June 8, 2007 stakeholder meeting.  It discusses potential plans and actions for a low carbon future in New Jersey.  The goals of the presentation are defined as: to examine the inventory estimates and forecasts; to review proposed potential climate measures for acceptability; to generate new ideas for consideration; to prioritize potential measures for future analysis and development; and to discuss the next steps.
Chrysochraon dispar subsp. dispar dispar (Germar 1834
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Chrysochraon
Chrysochraon dispar
Chrysochraon dispar dispar (germar, 1834)

description: 35.1. Chrysochraon dispar dispar (Germar, 1834)
First exact record in Croatia: Nagy 2006
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 55, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Chrysochraon dispar subsp. giganteus Harz 1975
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Chrysochraon
Chrysochraon dispar
Chrysochraon dispar giganteus harz, 1975

description: 35.2. Chrysochraon dispar giganteus Harz, 1975
First exact record in Croatia: Ingrisch, 1981
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 55, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Tuning metastasis using beta-blockers and biophysics
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: New treatment strategies are critically needed to block metastasis, which is the leading cause of cancer deaths. ß-blockers are anti-hypertension drugs that block ßAR signaling and are being clinically evaluated for cancer treatment. While altered tumor stiffness is associated with cancer progression, it is unclear how ß-blockers may alter the physical properties of circulating tumor cells to regulate metastasis. We recently discovered that ßAR signaling causes diverse types of cancer cells to be less deformable and more invasive. To guide translation of ß-blockers to the cancer clinic, it is now critical to investigate the effect of ß-blockers on the deformability and viability of disseminated tumor cells, and how this treatment impacts chemotherapy response. The proposed studies will determine how ß-blockade, together with existing chemotherapy treatments, regulates the deformability and viability of disseminated tumor cells to stop metastasis. We will utilize clinically-used ß-blockers, together with well-characterized ßAR agonists and common chemotherapy drugs to define effects on the deformability and viability of disseminated tumor cells after exposure to shear stresses during circulation. We will use cutting-edge fluidic devices, as well as mouse models of breast cancer and patient samples. Our multidisciplinary team consists of experts in biophysics and bioengineering (Rowat), cancer biology (Sloan), and pathology (Rao). Our Aims are to: 1) Determine the effects of ß-blockers and chemotherapy on the deformability and viability of tumor cells from patient pleural effusions. 2) Define the effects of ß-blockers and chemotherapy on the deformability and viability of circulating tumor cells in vivo. We will also determine how ß-blockers and tumor cell stiffness affects lodging in metastatic target organs. Results will define how ß-blockers may be combined with existing chemotherapy treatments to stop metastasis; such knowledge is essential to guide translation of ß-blockers to the clinic. Our findings will also provide crucial preliminary data for a competitive R01 proposal to NCI Neural Regulation of Cancer funding opportunity announcement (PAR-16-246).
Carcharhinus melanopterus
Creators: name: Golani, Daniel
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Carcharhinus
Carcharhinus melanopterus

description: Carcharhinus melanopterus (Quoy & Gaimard, 1824)
Carcharhinus melanopterus: Baranes, 1979 (Heb.); Golani, 1996; Golani, 2005.
description: Published as part of Golani, Daniel, 2021, An updated Checklist of the Mediterranean fishes of Israel, with illustrations of recently recorded species and delineation of Lessepsian migrants, pp. 1-108 in Zootaxa 4956 (1) on page 8, DOI: 10.11646/zootaxa.4956.1.1, http://zenodo.org/record/4691195
Context-Dependent Codon Optimality Drives Cell Proliferation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Transfer RNAs (tRNAs) are often considered uniform building blocks with little variation between cells, yet expression levels of tRNAs can profoundly affect cell properties. Multiple studies suggest that the stability of cancer-related messenger RNAs (mRNAs) is determined by tRNA abundance and codon usage. This relationship is based on “codon optimality”: mRNAs containing a high frequency of codons with abundant cognate tRNAs (optimal codons) are stable while mRNAs containing a high frequency of codons with rare cognate tRNAs (non-optimal codons) are rapidly degraded. We recently discovered a context-dependent role for codon optimality in Drosophila: codon optimality determines mRNA stability in developing tissues but optimal codons do not stabilize transcripts in differentiated neurons. Based on this discovery, we hypothesize that codon optimality balances neural progenitor proliferation versus differentiation during neural development. Context-dependent codon optimality may be due to differential expression of tRNAs in progenitors versus differentiated cells, alterations in the cellular machinery that links translation and mRNA stability, or a combination of these mechanisms. Drosophila neural progenitors are an excellent model for studying the balance between cell proliferation and differentiation, with dramatic brain tumors arising when this balance is altered. We propose to study codon optimality in Drosophila neural progenitors as a way to understand how tRNA abundance and codon usage can contribute to oncogenic transformation. This will be accomplished via two aims. Our first aim will measure mRNA decay, tRNA abundance, and codon optimality in progenitors versus neurons in different Drosophila mutants: a “brain tumor” mutant in which the brain primarily contains proliferating progenitors and a “premature differentiation” mutant in which the brain primarily contains post-mitotic neurons. These data will allow us to predict and test how specific tRNAs alter gene expression. Our second aim will dentify how codon optimality balances cell proliferation and differentiation using experimental manipulation of tRNA expression levels and genetic dissection of the regulatory pathway linking ribosome translocation and mRNA decay. This work will establish an animal model to study the effects of codon optimality on cell proliferation, a necessary step toward understanding codon optimality in cancer.
Ophion flavopictus Smith 1874
Creators: name: Shimizu, So
name: Broad, Gavin R.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion flavopictus

description: Ophion flavopictus Smith, 1874
(Figure 23)
Taxonomic history. The taxonomic status of this species has not been reviewed since its original description.
Taxonomy. Ophion flavopictus is a member of the Ophion obscuratus species-group.
Current taxonomy. Ophion flavopictus Smith, 1874 (Ichneumonidae: Ophioninae).
Type number. Type 3b.1308. Specimen # NHMUK010881038
Type status. Holotype.
Sex. Male.
Type locality. Hyôgo Prefecture, Honshû, Japan.
Label data. First label, ‘ Type /CM’ (round label, with red margin; first line printed and second line handwriting); second label, ‘B.M. TYPE /HYM./3b.1308’ (square label; first and second lines printed and third line handwriting); third label, ‘Hiogo/Japan’ (square label; first label handwriting and second line printed); fourth label, ‘74/16’ (round label; handwriting); sixth label, ‘ Ophion /flacopictus/ Type. Smith’ (square label; handwriting).
Condition. Rather good, but the third to fifth tarsomeres of the left fore leg, right second to fifth tarsomeres and left fourth to fifth tarsomeres of mid legs, fifth tarsomere of left hind leg, and the metasoma after the third segment are missing; the fourth to fifth tarsomeres of possibly the left mid leg are mounted on a glue board.
description: Published as part of Shimizu, So & Broad, Gavin R., 2020, Photographic catalogue of the oldest primary types of Japanese Ichneumonoidea (Hymenoptera), those described by Frederick Smith and Francis Walker in 1874, pp. 1115-1198 in Journal of Natural History 54 (17) on pages 1149-1152, DOI: 10.1080/00222933.2020.1776905, http://zenodo.org/record/4116141
Synthesis and Study of Anacardic Acid Derivatives
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The goal of this proposal is to develop novel therapeutic leads for the treatment of SUMO-dependent cancers through structure-activity relationship (SAR) and mechanism of action studies. Recently, it has been shown that a functioning SUMOylation pathway is critical to acute myeloid leukemia (AML) cells, and dysregulation of SUMO is associated with chemoresistance to current frontline treatments. Likewise, other chemoresistant cancers have shown a dependence on the SUMOylation pathway, often termed “non-oncogene addiction”. Using organic synthesis techniques, computational modeling and protein crystallography, we will design and synthesize analogs of anacardic acid with increased binding affinity and improved physical properties. Binding studies and inhibition assays will be performed by our collaborator (Prof. Jeff Perry, UC Riverside) to evaluate the success of these efforts (see Letter of Collaboration). The ultimate goal of these studies is to provide drug-like therapeutic leads for the treatment of SUMO-dependent cancers and to discover potent, selective probe molecules for use in further investigations of SUMOylation and its role in disease.
Dociostaurus brevicollis
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Dociostaurus
Dociostaurus brevicollis

description: 36. Dociostaurus brevicollis (Eversmann, 1848) = kratkovrati X-skakavac
First faunistic record for Croatia: Pongrácz 1944
Distribution in Croatia: Known only from the easternmost part of the Pannonian Basin in Croatia (Kopački rit). Pungur’s (1899) record from Srijem is not precise, since it can be either in Croatia or Serbia.
Distribution in Europe: From Austria and Czechia (western distribution border) to Greece and the European part of Turkey (southern border) and Eastern European Russia (Eastern border) (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on pages 55-56, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
A study of H2A.Z isoforms in Glioblastoma multiforme
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults with a median survival of 12-18 months from the time of initial diagnosis. GBM recurs in most cases and no standard treatment exists for the recurrent disease. Advances in basic understanding of GBM are therefore urgently required. Epigenetic mechanisms –processes that regulate gene expression by altering the epigenome – are one of the major factors contributing to the pathogenesis of cancers, including glioblastoma. Therefore, epigenetic modulators are being exploited as therapeutic drug targets. Histone 2A.Z (H2A.Z) is one such epigenetic modulator. H2A.Z is a highly-conserved histone 2A (H2A) variant that is overexpressed in breast, prostate and bladder cancers. H2A.Z has a complex biology. In mammals, H2A.Z has two paralogs (isoforms) – H2A.Z.1 and H2A.Z.2 – that are products of two non-allelic genes, H2AFZ and H2AFV. Although H2A.Z has been implicated in several forms of cancer, most studies have not clearly distinguished between the isoforms. One recent study reported a unique role for H2A.Z.2, and not H2A.Z.1, as a driver of malignant melanoma. In the current project, we are proposing to test the role of H2A.Z isoforms in GBM. Over the past three years, research on H2A.Z in our laboratory – a laboratory of neurobiology and epigenetics – has identified distinct roles of H2A.Z in neurodevelopment and brain functions. Now, we are proposing to extend our H2A.Z isoform-related tools and expertise to investigate the role of this major epigenetic player in GBM. In this seed project, we will manipulate levels of H2A.Z isoforms and their chaperones (proteins responsible for their nucleosomal inclusion/exclusion) in human and rat GBM cell lines respectively using RNAi and rescue approaches. We will observe effects of such manipulations on gene expression, cell proliferation, and cell survival. Once completed, these novel studies will provide insights into molecular mechanisms of GBM and set up a preliminary platform for subsequent in depth studies of H2A.Z isoform functions in these processes.
New Jersey: Confronting Climate Change in the U.S. Northeast
Creators: name: No Name Supplied
Publisher: name: Union of Concerned Scientists (UCS)
Year: 2007

description: This is a fact sheet for New Jersey based on a 2007 report on climate change in the northeast U.S. by the Northeast Climate Impacts Assessment (NECIA) Synthesis Team.    In October 2006, the NECIA released a report titled Climate Change in the U.S. Northeast, the product of a collaborative research effort that drew on recent advances in climate modeling to assess how global warming may further affect the Northeast's climate. Using projections from three state-of-the-art global climate models, the report compared the types and magnitude of climate changes that will result from two different scenarios of future heat-trapping emissions. The first (the higher-emissions scenario) is a future where people - individuals, communities, businesses, states, and nations - allow emissions to continue growing rapidly, and the second (the lower-emissions scenario) is one in which societies choose to rely less on fossil fuels and adopt more resource-efficient technologies.    This 2007 report builds upon and extends these findings. NECIA collaborators have used the NECIA climate projections to assess the impacts of these two very different future Northeast climates on vital aspects of the region's life and economy: coastal areas, marine fisheries, forests, agriculture, winter recreation, and human health. They also describe actions that can be taken today in the Northeast to reduce emissions and help avoid the most severe impacts of global warming and to adapt to the unavoidable changes that past emissions have already set in motion.
Ophion pungens Smith 1874
Creators: name: Shimizu, So
name: Broad, Gavin R.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion pungens

description: Ophion pungens Smith, 1874
(Figure 24)
Taxonomic history. Morley (1912) transferred this species from Ophion Fabricius, 1798 to Henicospilus Agassiz, 1846 (an unjustified emendation of Enicospilus Stephens, 1835).
Current taxonomy. Enicospilus pungens (Smith, 1874) (Ichneumonidae: Ophioninae).
Type number. Type 3b.1274. Specimen # NHMUK010881039
Type status. Holotype.
Sex. Male. Smith (1874) described the type as a female, but it is male.
Type locality. Hyôgo Prefecture, Honshû, Japan.
Label data. First label, ‘ Type /CM’ (round label, with red margin; first line printed and second line handwriting); second label, ‘B.M. TYPE /HYM./3b.1274’ (square label; first and second lines printed and third line handwriting); third label, ‘Hiogo/ Japan.’ (square label; first line handwriting and second line printed); fourth label, ‘74/16’ (round label; handwriting); sixth label, ‘ Ophion /pungens/ Type. Sm’ (square label; handwriting).
Condition. Rather good, but the right antenna is broken at the 7th flagellomere and left antenna at the 28th flagellomere. The metasoma is very weakly attached to the mesosoma.
description: Published as part of Shimizu, So & Broad, Gavin R., 2020, Photographic catalogue of the oldest primary types of Japanese Ichneumonoidea (Hymenoptera), those described by Frederick Smith and Francis Walker in 1874, pp. 1115-1198 in Journal of Natural History 54 (17) on page 1152, DOI: 10.1080/00222933.2020.1776905, http://zenodo.org/record/4116141
Carcharhinus obscurus
Creators: name: Golani, Daniel
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Carcharhinus
Carcharhinus obscurus

description: Carcharhinus obscurus (Lesueur, 1818)
Carcharhinus obscurus: Baranes & Darom, 1978 (Heb.); Baranes, 1979 (Heb.); Baranes & Diamant, 1983a (Heb.); Pisanty & Sonin, 1991 (Fish., Heb.); Pisanty & Sonin, 1992 (Fish., Heb.); Golani, 1996; Golani, 2005; Golani, 2006; Barash, 2014.
description: Published as part of Golani, Daniel, 2021, An updated Checklist of the Mediterranean fishes of Israel, with illustrations of recently recorded species and delineation of Lessepsian migrants, pp. 1-108 in Zootaxa 4956 (1) on page 8, DOI: 10.11646/zootaxa.4956.1.1, http://zenodo.org/record/4691195
Identifying Functional and Regulatory Domains in FLT3
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Fms-Like Tyrosine Kinase-3 (FLT3) is a receptor tyrosine kinase that is mutated in 30% of acute myeloid leukemia (AML). FLT3 is the most frequently mutated gene in AML, with mutations commonly occurring in the form of activating in-frame tandem duplication (ITD) mutations in the juxtamembrane (JM) domain. Patients with FLT3-ITD mutations carry an extremely poor prognosis. While the recent development of clinically effective FLT3 tyrosine kinase inhibitors (TKIs) has extended survival for newly diagnosed FLT3-mutant AML patients and improved response rates for relapsed/refractory FLT3-mutant patients, the majority of patients still relapse and die. Patients who relapse on FLT3 TKI therapy do so due to on-target FLT3 KD mutations, underscoring the central role of FLT3 as an oncogenic driver in this disease. Structural studies suggest that the FLT3 JM domain serves an auto-inhibitory role in kinase regulation and this function is disrupted by ITD mutations. Rare deletion mutations in the FLT3 JM domain have been identified in patients, further supporting the role of this domain in FLT3 regulation. Widespread genomic sequencing of AML and other tumors has revealed mutations in other FLT3 domains of uncertain significance. Mutagenesis studies in mouse models have suggested N-terminally truncated FLT3 protein lacking most of the extracellular domain can cause ligand-independent FLT3 activation and result in leukemic transformation. This observation implicates the FLT3 extracellular domain in FLT3 regulation and autoinhibition. At this time, the functional role of FLT3 protein domains in FLT3 kinase regulation remains incompletely understood. Recently, Shi et al. (Nature Biotech 2015) pioneered the use of exon-targeted CRISPR-Cas9 genome editing to identify functional protein domains, based on the assumption that cells with CRISPR-edited mutations in critical protein domains undergo disproportionate negative selection over time. We propose to adapt this technique to identify and validate the protein domains of FLT3 relevant to kinase regulation by assaying for FLT3 domain mutations which result in cytokine independent transformation or conversely, negative selection in FLT3-driven cell lines. By understanding the functional domains of FLT3 relevant to FLT3 function and oncogenesis, we hope to identify critical domains that might be targeted therapeutically.
Outcomes in Stage IV Cancer Patients with Bowel Obstruction
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Although patients and clinicians consider oncologic outcome and survival the pre-eminent goals of cancer therapy, quality of life (QOL) and avoidance of therapeutic morbidity, particularly among patients with stage IV cancer, are receiving increasing attention as important goals of care. Consequently, prolonged hospitalizations, intensive care stays, emergency room visits, hospital readmissions, and aggressive therapies, such as chemotherapy and surgery, have come under scrutiny given the increasing emphasis on improved palliative care and QOL for patients near their end of life. These issues create a dilemma for surgeons, as patients with disseminated malignancy (DMa) commonly present with acute surgical conditions, such as malignant bowel obstructions (MBO), for which surgery has historically been the standard of care. The goal of this proposal is to examine the morbidity, mortality and surrogate endpoints for QOL among patients with DMA who present with MBO and are treated medically versus surgically. We hypothesize that surgical management will lead to higher rates of these morbidity/adverse QOL outcomes with correspondingly negligible differences in overall survival. We will test our hypothesis through the following specific aims: Aim 1: To demonstrate that rates of morbidity and associated endpoints (e.g. prolonged hospitalizations) are higher for surgically-managed versus medically-managed DMa patients with MBO. Aim 2: To compare overall survival between the surgically and medically managed cohorts. We will test this hypothesis using the California Office of Statewide Health Planning and Development database, specifically consisting of patients with the diagnosis of DMa and MBO admitted to a California licensed hospital from 2005 to 2010. We will obtain inpatient and emergency visit data to evaluate differences in endpoints (i.e. morbidity, prolonged hospitalizations, ICU stays, readmission, emergency room visits and disposition to nursing facilities) for surgically versus medically-managed patients. In addition, we will use linked death data to examine differences in survival among cohorts. These data will have important implications for patients and surgeons as the data will provide a population-based assessment of the impact of medical versus surgical management on morbidity and survival as well as important metrics of QOL. This research is critical to shared patient and surgeon decision-making for this increasingly common and high risk patient population.
Confronting Climate Change in the U.S. Northeast: Science, Impacts, and Solutions: Executive Summary
Creators: name: No Name Supplied
Publisher: name: Union of Concerned Scientists (UCS)
Year: 2007

description: This is the executive summary of a 2007 report on climate change in the northeast U.S. by the Northeast Climate Impacts Assessment (NECIA) Synthesis Team.    In October 2006, the NECIA released a report titled Climate Change in the U.S. Northeast, the product of a collaborative research effort that drew on recent advances in climate modeling to assess how global warming may further affect the Northeast's climate. Using projections from three state-of-the-art global climate models, the report compared the types and magnitude of climate changes that will result from two different scenarios of future heat-trapping emissions. The first (the higher-emissions scenario) is a future where people - individuals, communities, businesses, states, and nations - allow emissions to continue growing rapidly, and the second (the lower-emissions scenario) is one in which societies choose to rely less on fossil fuels and adopt more resource-efficient technologies.    This 2007 report builds upon and extends these findings. NECIA collaborators have used the NECIA climate projections to assess the impacts of these two very different future Northeast climates on vital aspects of the region's life and economy: coastal areas, marine fisheries, forests, agriculture, winter recreation, and human health. They also describe actions that can be taken today in the Northeast to reduce emissions and help avoid the most severe impacts of global warming and to adapt to the unavoidable changes that past emissions have already set in motion.
The Role of p21 Phosphorylation at S123 in Tumor Suppression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The cyclin-dependent kinase (CDK) inhibitor p21, also known as WAF1 and CIP1, is a potent suppressor of cell growth and belongs to the Cip/Kip family of cdk inhibitors. p21 is a target of tumor suppressor p53 and mediates p53-dependent cell cycle arrest in response to DNA damage. Due to its potent role in growth suppression, p21 was originally identified as a tumor suppressor. Interestingly, recent studies also showed that p21 has an oncogenic activity as cytoplasmic localization of p21 promotes cell proliferation. Indeed, accumulation of cytoplasmic p21 is found in several types of cancers and associated with tumor progression and poor prognosis. Together, these studies suggest that depending on its cellular context, p21 could inhibit or promote tumorigenesis. Thus, understanding the mechanism how p21 activity is controlled may open a new avenue to explore p21 as a therapeutic target for cancer treatment. We previously cloned the canine CDKN1A gene and found that like human p21, canine p21 is induced by DNA damage in a p53-dependent manner and modulates p53-dependent cell cycle arrest. Interestingly, canine p21 is expressed as two isoforms due to proline-directed phosphorylation at serine 123 (S123), which can be easily visualized as a slower migrating band than the underphosphorylated canine p21. Interestingly, ectopic expression of mutant canine p21(S123D), in which serine 123 was substituted with phosphomimetic aspartate acid, greatly inhibited cell proliferation as compared to that of canine p21(S123A), in which serine 123 was replaced with non-phosphorylatable alanine. However, the role of serine 123 in p21-mediated growth suppression has not been studied in vivo. Interestingly, our pilot study indicated that the level of S123-phosphorylated p21 was reduced by lithium chloride (LiCl), an inhibitor of glycogen synthase kinase 3 (GSK3). Thus, we hypothesize that posphorylation of serine 123 plays a critical role in p21-mediated growth suppression. To test this, we will determine: (1) whether GSK3 phosphorylates canine p21 at S123; (2) whether S123 phosphorylation enhances canine p21-mediated tumor suppression in vitro and in vivo.