The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study
Creators: name: Bethell, George S.
name: Long, Anna-May
name: Knight, Marian
name: Hall, Nigel J.
name: Jones, Abigail
name: Aslam, Adil
name: Mortell, Alan
name: McCabe, Amanda
name: Ross, Andrew
name: Harris, Anna
name: Lawson, Anne
name: Kelay, Arun
name: Abhyankar, Aruna
name: Rajimwale, Ashok
name: Bandi, Ashwath
name: Saeed, Atif
name: Eradi, Bala
name: Sharif, Baqer
name: MacCormack, Brian
name: Pardy, Caroline
name: Ridd, Catherine
name: Jones, Ceri
name: Nicoara, Cezar
name: Driver, Chris
name: Parsons, Chris
name: Kwok, Chun-Sui
name: Rees, Clare
name: Skerritt, Clare
name: Magnie, Damian
name: Aronson, Dan
name: Marshall, David
name: Deacy, Dawn
name: Banerjee, Debasish
name: De Caluwe, Diane
name: Kufeji, Dorothy
name: Cusick, Eleri
name: O’Connor, Elizabeth
name: Bough, Georgina
name: Racheva, Gergana
name: Murthi, Govind
name: Ghattaura, Harmit
name: Patel, Hetal
name: Jones, Ian
name: Sugarman, Ian
name: Njere, Ike
name: Jester, Ingo
name: Durell, Jonathan
name: Davidson, Joseph
name: Sloan, Keren
name: Cao, Kevin
name: Elmalik, Khalid
name: Smith, Lee
name: Nellihela, Leel
name: Lopes
name: Tullie, Lucinda
name: Henderson, Lucy
name: Kakade, Madhavi
name: Haneef, Maryam
name: Matcovici, Melania
name: Dawrant, Michael
name: Horridue, Michelle
name: Soares-Oliveira, Miguel
name: Doyle, Miriam
name: Shalaby, Mohamed
name: Allan, Morven
name: Burdell, Oliver
name: Charlesworth, Paul
name: Johnson, Paul
name: Halim, Rahman
name: Hill, Richard
name: Peeraully, Riyad
name: Cresner, Rosie
name: Craigie, Ross
name: Gupta, Samir
name: Motiwale, Sandeep
name: Besarovic, Sanja
name: Paramalingam, Saravanakumar
name: Marven, Sean
name: Patel, Shailesh
name: Sharif, Shazia
name: Naqvi, Shehryer
name: Clarke, Simon
name: Kenny, Simon
name: Eriksson, Sofia
name: Payne, Susan
name: Tyraskis, Thanos
name: Tsang, Thomas
name: Bradnock, Tim
name: Calvert, William
name: Patel, Yatin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original Article
Duodenal atresia
Duodenal stenosis
Down syndrome
Trisomy 21
Congenital cardiac disease

description: Abstract: Purpose: Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO. Methods: Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly. Results: Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23–41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p &lt; 0.001), whereas associated gastrointestinal anomalies were less common in infants with T21 (3 vs 12%, p = 0.03). Surgical management was not influenced by T21. Time to achieve full enteral feed, need for repeat related surgery, and mortality were similar between groups. Infants with T21 had a longer median initial inpatient stay (23 vs 16.5 days, p = 0.02). Conclusions: Infants with T21 have a higher incidence of cardiac anomalies and a longer initial inpatient stay; however, it does not change CDO management or outcomes. This information is important for prenatal and postnatal counselling of parents of infants with CDO and T21.