cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity
Creators: name: Davies, Tim
name: Kim, Han X.
name: Romano Spica, Natalia
name: Lesea-Pringle, Benjamin J.
name: Dumont, Julien
name: Shirasu-Hiza, Mimi M.
name: Canman, Julie
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Cell division
subject: Embryonic stem cells--Research
subject: Microbiology
subject: FOS: Biological sciences
subject: Cytokines--Pathophysiology
subject: Cytology

description: Cytokinesis, the physical division of one cell into two, is powered by constriction of an actomyosin contractile ring. It has long been assumed that all animal cells divide by a similar molecular mechanism, but growing evidence suggests that cytokinetic regulation in individual cell types has more variation than previously realized. In the four-cell Caenorhabditis elegans embryo, each blastomere has a distinct cell fate, specified by conserved pathways. Using fast-acting temperature-sensitive mutants and acute drug treatment, we identified cell-type-specific variation in the cytokinetic requirement for a robust forminCYK-1-dependent filamentous-actin (F-actin) cytoskeleton. In one cell (P2), this cytokinetic variation is cell-intrinsically regulated, whereas in another cell (EMS) this variation is cell-extrinsically regulated, dependent on both SrcSRC-1 signaling and direct contact with its neighbor cell, P2. Thus, both cell-intrinsic and -extrinsic mechanisms control cytokinetic variation in individual cell types and can protect against division failure when the contractile ring is weakened.
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
Creators: name: Conlon, Erin Grace
name: Fagegaltier, Delphine
name: Agius, Phaedra
name: Davis-Porada, Julia
name: Gregory, James
name: Hubbard, Isabel
name: Kang, Kristy
name: Kim, Duyang
name: Consortium, The New York Genome Center ALS
name: Phatnani, Hemali
name: Shneider, Neil A.
name: Manley, James L.
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Medical genetics--Research
subject: Medical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Diseases
subject: Diagnosis
subject: Amyotrophic lateral sclerosis
subject: Frontotemporal dementia
subject: Neurology

description: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These include near ubiquitous pathological inclusions of the RNA-binding protein (RBP) TDP-43, and often the presence of a GGGGCC expansion in the C9ORF72 (C9) gene. Previously, we reported that the sequestration of hnRNP H altered the splicing of target transcripts in C9ALS patients. Here, we show that this signature also occurs in half of 50 postmortem sporadic, non-C9 ALS/FTD brains. Furthermore, and equally surprisingly, these ‘like-C9’ brains also contained correspondingly high amounts of insoluble TDP-43, as well as several other disease-related RBPs, and this correlates with widespread global splicing defects. Finally, we show that the like-C9 sporadic patients, like actual C9ALS patients, were much more likely to have developed FTD. We propose that these unexpected links between C9 and sporadic ALS/FTD define a common mechanism in this disease spectrum.
Life Cycle Assessment of Rare Earth Metals Production: Hotspot Analysis of Didymium Electrolysis Process
Creators: name: Fukurozaki, Sandra Harumi
name: Neto, João Batista Ferreira
name: Nunis da Silva, André Luiz
name: Landgraf, Fernando José Gomes
Publisher: name: figshare
Year: 2021
Subjects: subject: 90702 Environmental Engineering Modelling
subject: FOS: Environmental engineering

description: ICALCA 2019: International Conference on Advances in Life Cycle Assessment, Paris, France, March 208-29, 2019.

Open Science Index, Energy and Environmental Engineering Vol:13, No:3, 2019
title: Adolescent Dating Violence and Healthcare Interventions: A Systematic Scoping Review
Creators: name: Vijh, Ruchi
Publisher: name: Arts
Year: 2024
Subjects: subject: Adolescent dating violence
subject: Healthcare
subject: Prevention
subject: Intervention
subject: Implementation
subject: Public Health
subject: Health Care Management
subject: Psychology--Developmental

description: Adolescent dating violence (ADV) is a significant public health problem globally. Experiencing ADV is associated with several short- and long-term physical and psychological adverse health outcomes. Therefore, it is crucial to implement prevention and intervention strategies to address ADV in settings that serve adolescents. One natural point of contact is healthcare settings, as adolescents may present to these settings due to health concerns related to ADV exposure. Thus, healthcare providers are well-positioned to engage in ADV prevention and intervention strategies. However, little is known about the state of the science for how adolescent healthcare providers can participate in ADV prevention and intervention approaches, as well as the potential barriers healthcare providers may face when incorporating such strategies into their practice. To advance understanding, a systematic scoping review was conducted to summarize current evidence on 1) ADV prevention and intervention strategies in healthcare settings, and 2) healthcare provider perspectives on implementing these strategies. This review included peer-reviewed articles published in English from any time until September 2023. After excluding duplicates, the search yielded 5786 articles, 11 of which met the inclusion criteria and were included in this review. Overall, there were only a few studies on ADV preventive interventions designed for implementation in various healthcare settings. Common barriers identified to implementing ADV prevention and intervention strategies included limited time, training, and resources. Facilitators of implementation included ADV response protocols or guidelines and working in collaborative teams. This systematic scoping review demonstrates that further research is needed to develop and evaluate ADV prevention and intervention strategies in healthcare settings, and to understand barriers to implementing these strategies.
Half-trek criterion for generic identifiability of linear structural equation models
Creators: name: Foygel, Rina
name: Draisma, Jan
name: Drton, Mathias
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: A linear structural equation model relates random variables of interest and corresponding Gaussian noise terms via a linear equation system. Each such model can be represented by a mixed graph in which directed edges encode the linear equations and bidirected edges indicate possible correlations among noise terms. We study parameter identifiability in these models, that is, we ask for conditions that ensure that the edge coefficients and correlations appearing in a linear structural equation model can be uniquely recovered from the covariance matrix of the associated distribution. We treat the case of generic identifiability, where unique recovery is possible for almost every choice of parameters. We give a new graphical condition that is sufficient for generic identifiability and can be verified in time that is polynomial in the size of the graph. It improves criteria from prior work and does not require the directed part of the graph to be acyclic. We also develop a related necessary condition and examine the "gap" between sufficient and necessary conditions through simulations on graphs with 25 or 50 nodes, as well as exhaustive algebraic computations for graphs with up to five nodes.
description: Published in at http://dx.doi.org/10.1214/12-AOS1012 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Bulbothrix viatica Spielmann & Marcelli
Creators: name: R, Jeanne dos
name: Silva, eis
name: Aptroot, André
name: E, Marcela
name: S, ugenia da
name: Cáceres, ilva
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Lecanoromycetes
Lecanorales
Parmeliaceae
Bulbothrix
Bulbothrix viatica

description: Bulbothrix viatica Spielmann & Marcelli
PREVIOUS REPORT. — Spielmann & Marcelli (2008).
 NEW REPORT. — Chapada do Céu, Parque Nacional das Emas, on bark, leg. A. Aptroot s.n.
description: Published as part of R, Jeanne dos, Silva, eis, Aptroot, André, E, Marcela, S, ugenia da & Cáceres, ilva, 2023, Lichens from dry central Brazil: a checklist of lichenized fungi from Distríto Federal and Goiás, pp. 117-133 in Cryptogamie, Mycologie 20 (9) on page 125, DOI: 10.5252/cryptogamie-mycologie2023v44a9, http://zenodo.org/record/8434271
title: บทวิจารณ์หนังสือ: ความรู้เบื้องต้นเกี่ยวกับกฎหมายทั่วไป โดย หยุด แสงอุทัย
Creators: name: ปัณมาสน์ อร่ามเรือง
Publisher: name: สาขารัฐประศาสนศาสตร์ คณะศิลปศาสตร์ มหาวิทยาลัยกาฬสินธุ์
publisherIdentifierScheme: ROR
Year: 2012
Subjects: -

description: วารสารรัฐศาสตร์และนิติศาสตร์ มหาวิทยาลัยราชภัฏกาฬสินธุ์, 1, 1, 166-169
title: Neighbourhood Built Characteristics and their Associations with Health-related Fitness in Adults
Creators: name: Frehlich, Levi Colt
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Epidemiology
subject: Public Health

description: Health-related fitness is an important marker of overall health, linked to lower morbidity and mortality. Consistently, evidence associates the neighbourhood built environment with physical activity and with health outcomes. However, sparse evidence links the neighbourhood built environment and health-related fitness. Existing studies typically focussed on cardiorespiratory or morphological fitness, yet health-related fitness is multidimensional. It remains unclear whether neighbourhood built environments that support physical activity also promote or enhance health-related fitness. Evidence suggests there are sex differences in associations between the neighbourhood built environment and physical activity. Therefore, this thesis elucidates the associations between the neighbourhood built environment and components of health-related fitness among urban-dwelling adults stratified on sex. Our systematic review found the neighbourhood built environment was associated with health-related fitness in adults and that in some cases, these associations were independent of physical activity. A secondary analysis of national data found neighbourhood walkability was positively associated with cardiorespiratory fitness but negatively associated with muscular strength, while controlling for accelerometer-measured physical activity. This was followed by a secondary analysis of provincial data associated neighbourhood built characteristics (walkability and greenness) which included muscular strength and body composition, independent of self-reported physical activity and sedentary behaviour. This study found that neighbourhood walkability may support cardiorespiratory and morphological fitness, whereas neighbourhood greenness may positively impact muscular fitness. Relationships between the neighbourhood built environment and health-related fitness were similar for males and females. In summary, neighbourhood built environments that support physical activity might also promote health-related fitness.
title: Analyzing the Role of Theatre in Integrating Immigrants into the Host Society through Communicative Action
Creators: name: Asgarian, Saeid
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Theatre
subject: Integration
subject: Immigrants
subject: Communication
subject: Society
subject: Theater

description: Western societies are growing and changing rapidly with an increase in immigrants over the last two decades. Every year, many people with different cultures and backgrounds immigrate into modern societies, such as Canadian society. One of the responsibilities of these modern societies is to help immigrants integrate into their new society in a multiplicity of ways. In this research, I analyze how theatre as a social tool can help integrate immigrants into a Canadian context, specifically Calgary, Alberta. This research aims to show how theatre can positively affect the integration of immigrants into their new society leveraging both social and performance studies sciences. Anchored in the theories of social scientist Jürgen Habermas, I define the terms ‘society’ and ‘modern society’ and identify success criteria for integration in said ‘modern society.’ I then conduct an overview of various definitions of theatre and performance experiences utilizing the theories of seminal stage directors Bertolt Brecht, Peter Brook, Jerzy Grotowski, and Augusto Boal. In doing so, I attempt to create a framework and understanding of the characteristics of this art form which will support my analysis. I propose a relationship between the commonalities in these theatre styles and Jürgen Habermas' theory of communicative action. In addition, I apply this framework further by leveraging the theories of Nelson Goodman and Irving Goffman to illuminate how a theatre group can be a small sample of society in which to practice the theory of communicative action. Finally, using a Practice as Research (PaR) methodology, I share qualitative data obtained from two case study performances I created and directed in my graduate work, Green Key (2023), and Absence (2023), where I demonstrate how I used the theory of communicative action in rehearsals. This research asserts that theatre can significantly impact the audience's lifeworld, awareness, and perspective. In this way, it can benefit the integration of unintegrated groups such as immigrants.
Therapy-related hepatic mitochondrial dysfunction in patients co-infected with human immunodeficiency virus and hepatitis C virus and in HepG2 cells
Creators: name: Taillefer, Rachel Elise
Publisher: name: University of British Columbia
Year: 2012

description: Background: Co-infection with HIV and hepatitis C virus (HCV) worsens liver disease and decreases highly active antiretroviral therapy (HAART) tolerability. HAART usually includes two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI) or a non-NRTI (NNRTI). NRTIs, particularly D-NRTIs, can induce mitochondrial DNA (mtDNA) depletion, deletions or mutations and lead to mitochondrial dysfunction. Multi-drug resistance protein-1 (MDR1) transports drugs across cellular membranes and may modulate toxicity. This project investigated HAART-related mitochondrial toxicity in liver tissue from HIV/HCV co-infected individuals and in human hepatic (HepG2) cells. Hypotheses: 1) Patients ON-HAART will have altered pathology scores, mtDNA quantity/deletions and mt-mRNA/MDR1-mRNA levels compared to patients OFF-HAART, and these will be influenced by type of HAART. 2) Treatment with the d-NRTI didanosine (ddI) and the PI saquinavir (SAQ) will alter HepG2 cell viability, population doubling time (PDT) and mtDNA content. Methods: Double-liver biopsies were collected from HIV/HCV co-infected individuals. One sample was used to score pathology, the other to extract DNA and RNA. mtDNA quantity, mt-mRNA and MDR1-mRNA levels were investigated by quantitative-PCR and mtDNA deletion by long-template PCR. Measurements were compared between individuals ON- versus OFF-HAART, on D-NRTI versus other NRTIs and on PI versus NNRTI. HepG2 cells were exposed to ddI and SAQ. Cell viability, PDT and mtDNA content were investigated. Results: Individuals ON-HAART (N=34) were similar in age, gender and HCV genotype to those OFF-HAART (N=18), and the groups did not differ significantly in pathology score, mtDNA quantity/deletions or mt-mRNA/MDR1-mRNA levels. The same was true for individuals on D-NRTI (N=6) versus other NRTIs (N=28) and on PI (N=17) versus NNRTI (N=8), except that individuals on PI were older (p=0.044) with higher mt-mRNA levels (p=0.015). Treatment of HepG2 cells with ddI lowered mtDNA content while SAQ decreased PDT. Addition of a second drug (SAQ or ddI) exacerbated these effects. ddI transiently decreased viability. Conclusions: The lack of differences between the ON- and OFF-HAART groups supports previous observations that HAART is not associated with increased hepatic mitochondrial toxicity although the cell culture findings suggest complementary toxicity upon co-exposure to ddI/SAQ. This study may inform management of HIV/HCV co-infected individuals.
Two-charged non-extremal rotating black holes in seven-dimensional gauged supergravity: The single-rotation case
Creators: name: Wu, Shuang-Qing
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct the solution for non-extremal charged rotating black holes in seven-dimensional gauged supergravity, in the case with only one rotation parameter and two independent charges. Using the Boyer-Lindquist coordinates, the metric is expressed in a generalized form of the ansatz previously presented in [S.Q. Wu, Phys. Rev. D 83 (2011) 121502(R)], which may be helpful to find the most general non-extremal two-charged rotating black hole with three unequal rotation parameters. The conserved charges for thermodynamics are also computed.
description: 13 pages, elsarticle.cls, revised version with two typos removed and three references added
title: Essays in Empirical Economics
Creators: name: Yu, Wenshuang
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Product Innovation
subject: Trade Policy
subject: COVID-19
subject: Import Competition
subject: Advanced Technology
subject: Economics

description: This thesis consists of three essays in empirical economics. The first two essays explore whether and how trade policies impact individual firms decision-making and how these decisions affect economic growth in developing countries. Specifically, in the first essay, I study whether improved access to high-income countries increases product innovation. To do so, I use administrative firm and Customs data and exploit a reform that significantly increased high-income market access for firms in China. My results show that improved access to high-income markets causes firms to produce new products, which explains about 26\% of the observed increase in product innovation from 2000 to 2007. Additionally, I find that these gains are primarily driven by the increase in revenue generated by exporting to high-income countries. These results highlight the importance of improving access to high-income developing countries for the economic growth in developing countries. In the second essay, which is joint work with Felix Fosu, we study how exposure to imports affects firms' decisions to upgrading foreign production technology in China. To do this, we exploit industry-level variations in tariff reductions generated by China's accession to the WTO in December 2001. This disparity in tariff reductions across industries leads to different levels of import competition across industries. Using the cross-industry variations in import competition, we show that increased import competition diminishes firms' willingness to upgrade their technology, consistent with a type of Schumpeterian effect in that the additional product market competition reduces the marginal return to upgrade production technology. In the third essay, which is a joint work with Gillian Petit and Lindsay M. Tedds, we investigate the effect of COVID-19 pandemic on public transit revenues in Calgary. Using a difference-in-differences strategy, we find that COVID-19 had the largest impact on adult transit fare revenue, a smaller impact on youth fares, and almost no impact on low-income fares suggesting that youth and low-income transit pass users were less able to substitute away from or forgo public transit during the COVID-19 shock, unlike adults. Reductions in transit services that occurred at the same time were more likely borne by youth and low-income transit users. To minimize service reductions and their inequitable effects, we argue that given municipalities have little financial power and flexibility, higher orders of government should provide transit operating funding during times of transit fare shocks.
Various Material Development Strategies for Suitable Catalysts of Photo Catalytic Water Splitting to Green Fuel H2:A Critical Review
Creators: name: Habib, Md. Shehan
Publisher: name: figshare
Year: 2021
Subjects: subject: 20504 Photonics, Optoelectronics and Optical Communications
subject: FOS: Physical sciences
subject: Quantum Mechanics
subject: Thermodynamics
subject: 20299 Atomic, Molecular, Nuclear, Particle and Plasma Physics not elsewhere classified
subject: Mechanics

description: Fossil fuels are the most substantial & extensively used sources of energy for today’s world. Simultaneously, the unconscious exposure of toxic pollutants and green-house gases allied with fossil energy is not viable with contexture. Solar energy were treated as an auspicious source of energy from ancient age because of its richness & cleanness. But problem arises in its capture, storage, transformation, and distribution. That’s why scholars are trying to convert this renewable light energy to a user friendly and viable form of energy. By analyzing recent studies on H2 fuel it is considered as most lucrative choice for clean and sustainable fuel with high calorific value & zero pollution. This review offers an overview of most recent advancement in development of photo-catalyst for solar water splitting which is treated as a promising Green-Harvesting technique among all H2 generation techniques. Here we discussed about various catalyst development techniques especially about doping techniques, reactor design and light scattering/trapping systems.We found that among all doping is a promising technique and a lots of study have been done on this technique than others like as Hetero junction, Dye sensitization, modification of surface or nanostructure formation. Hence we concluded with the decision that, more research are needed on hetero junction and nanostructure formation along with elemental doping.
Mastering MUPS Tablet Compression: Challenges and Solutions
Creators: name: Alam, ABM Mahfuz ul
Publisher: name: Zenodo
Year: 2023

description: This article delves into the intricacies of Multiple Unit Pellet System (MUPS) tablet compression, an innovative pharmaceutical formulation technique with significant potential for improving drug delivery systems. The challenges associated with MUPS tablet compression, including achieving uniform pellet size distribution, blend homogeneity, compression force optimization, coating complexities, and tooling considerations, are thoroughly explored. The article emphasizes the critical role of advanced technologies, precise control over process parameters, and vigilant quality control measures in overcoming these challenges. As the pharmaceutical industry continues to evolve, mastering MUPS tablet compression emerges as a pivotal avenue for enhancing drug delivery systems and ultimately improving patient outcomes. The comprehensive insights provided herein contribute to the scientific understanding of MUPS tablet compression and guide pharmaceutical manufacturers toward producing high-quality and patient-centric medications.
Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease
Creators: name: Manichaikul, Ani
name: Wang, Xin-Qun
name: Li, Li
name: Erdmann, Jeanette
name: Lettre, Guillaume
name: Bis, Joshua C.
name: Waterworth, Dawn
name: Cushman, Mary
name: Jenny, Nancy S.
name: Post, Wendy S.
name: Palmas, Walter R.
name: Tsai, Michael Y.
name: Wallentin, Lars
name: White, Harvey
name: Schunkert, Heribert
name: O’Donnell, Christopher J.
name: Herrington, David M.
name: Rich, Stephen S.
name: O’Donoghue, Michelle L.
name: Rodriguez, Annabelle
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Cardiovascular system--Diseases
subject: Genetics
subject: FOS: Biological sciences
subject: Inflammation
subject: Atherosclerosis
subject: Medicine

description: Background
We previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been reported in association with Lp-PLA2 mass and activity, we hypothesized that inflammatory pathways might mediate the association of rs10846744 with atherosclerosis.

Methods
We first examined association of rs10846744 in CVD in multiple large-scale consortium-based genome-wide association studies. We further examined 27 parameters of interest, including Lp-PLA2 mass and activity, inflammatory markers, and plasma phospholipid fatty acids, and fatty acid ratios in participants from the Multi-Ethnic Study of Atherosclerosis (MESA), as potential mediators in the pathway linking rs10846744 with cIMT and incident CVD. Finally, we examined the association of rs10846744 with Lp-PLA2 activity, cardiovascular outcomes, and interaction with the Lp-PLA2 inhibitor, darapladib, in the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy (STABILITY) and Stabilization of Plaque using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) studies.

Results
SCARB1 rs10846744 was associated with coronary artery disease events in CARDIoGRAMplusC4D (odds ratio 1.05; 95% CI [1.02, 1.07]; P = 1.4x10-4). In combined analysis across race/ethnic groups in MESA, rs10846744 was associated with Lp-PLA2 mass (P = 0.04) and activity (P = 0.001), homocysteine (P = 0.03), LDL particle number (P = 0.01), docosahexaenoic acid [DHA] (P = 0.01), docosapentaenoic acid [DPA] (P = 0.04), DPA/ eicosapentaenoic acid [EPA] ratio (P = 0.002), and DHA/EPA ratio (P = 0.008). Lp-PLA2 activity was identified as a mediator of rs10846744 with cIMT in a basic model (P = 8x10-5), but not after adjustment for CVD risk factors. There was no interaction or modifier effect of the Lp-PLA2 inhibitor darapladib assignment on the relationship between rs10846744 and major CVD events in either STABILITY or SOLID-TIMI 52.

Summary
SCARB1 rs10846744 is significantly associated with Lp-PLA2 activity, atherosclerosis, and CVD events, but Lp-PLA2 activity is not a mediator in the association of rs10846744 with cIMT in MESA.
Data-driven brain network models differentiate variability across language tasks
Creators: name: Bansal, Kanika
name: Medaglia, John D.
name: Bassett, Danielle S.
name: Vettel, Jean M.
name: Muldoon, Sarah F.
Publisher: name: Columbia University
Year: 2018
Subjects: Neural circuitry
Language and languages--Physiological aspects
Neuropsychiatry
Neural networks (Neurobiology)--Mathematical models
Neurology

description: The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of anatomical brain organization on human task performance, we use a data-driven computational modeling approach and explore the functional effects of naturally occurring structural differences in brain networks. We construct personalized brain network models by combining anatomical connectivity estimated from diffusion spectrum imaging of individual subjects with a nonlinear model of brain dynamics. By performing computational experiments in which we measure the excitability of the global brain network and spread of synchronization following a targeted computational stimulation, we quantify how individual variation in the underlying connectivity impacts both local and global brain dynamics. We further relate the computational results to individual variability in the subjects’ performance of three language-demanding tasks both before and after transcranial magnetic stimulation to the left-inferior frontal gyrus. Our results show that task performance correlates with either local or global measures of functional activity, depending on the complexity of the task. By emphasizing differences in the underlying structural connectivity, our model serves as a powerful tool to assess individual differences in task performances, to dissociate the effect of targeted stimulation in tasks that differ in cognitive demand, and to pave the way for the development of personalized therapeutics.
title: Impacts of Increased Home Care Investments on Health System Service Utilization
Creators: name: Jajszczok, Max
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: home care
subject: economic analysis
subject: quality
subject: performance
subject: outcomes
subject: evaluation
subject: cost-effectiveness
subject: Health Care Management

description: Introduction: A Canadian home care performance measurement framework does not exist. This research examined the impact of Federal and Provincial investments in home care programs in Alberta. We identified the need for financially focused home care system indicators, refined indicators through a modified Delphi approach, and applied selected indicators within the Alberta context. Methods: We conducted a three-phase multistage, mixed-methods study. 1.) Through a scoping review, we identified measures, frameworks and related evaluation tools specific to the IHI Quadruple Aim as applied to home care programs. 2.) We identified core financially focused measurement indicators using a modified Delphi process and a Content Analysis approach. 3.) We applied the newly identified indicators to Alberta Health Services data for home care clients from 2015 to 2020. The identified indicators were examined through trend analyses and a cost-effectiveness analysis economic evaluation. Results: In the first study, we reviewed 3,475 potential documents, leading to 105 articles for performance and quality indicator (PQI) extraction, identifying 829 unique PQIs. Under the IHI Quadruple Aim, 661 PQIs were Clinical Outcomes, 35 Healthcare Provider Satisfaction, 99 Patient Experience, and 34 Financial. In our second phase, 12 panellists comprised the first round and selected 30 PQIs. The second round, comprising eight panellists, resulted in consensus on three PQIs: “Average cost per day per home care client,” “Home care service cost per client over time,” and “Home care funding as a percentage of health care expenditures.” In our third phase, trend analyses identified that enhanced home care investments per client and overall expenditures in Alberta led to a decrease in acute care usage. Over five years, the model estimated a reduction of 346,200 patient days in acute care. An additional $240.3M in home care investments yielded a Cost Effectiveness Ratio of 694:1 in acute care beds days avoided. Conclusions: Our research identified and applied new cost-based indicators effectively portraying how targeted funding affects utilization, revealing that enhancing home care programs improves system cost-effectiveness. Policymakers are encouraged to incorporate these novel indicators into their measurement frameworks to gauge the effects of home care investments on the overall health system.
title: The impact of pediatric mild traumatic brain injury on intrinsic excitability and susceptibility to ionic dysregulation throughout lifetime
Creators: name: McCluskey, Samantha Joanne
Publisher: name: Arts
Year: 2024
Subjects: subject: pediatric mild traumatic brain injury
subject: excitability
subject: ionic dysregulation
subject: Neuroscience

description: Mild traumatic brain injuries (mTBI) are common mechanical traumas to the head that result in either no or transient (<30 min) loss of consciousness, representing approximately 80% of TBIs reported worldwide1,2. Increasing incidence of mTBI make them a growing public health concern1. Despite being termed ‘mild’, approximately 30% of mTBI patients experience long-term functional deficits1,3. Importantly, the effects of pediatric mTBI (pmTBI) are understudied compared to the adult population1,2. In addition, mTBI symptoms and pathophysiology is sexually dimorphic at both clinical and preclinical levels. To better understand the mechanisms and longitudinal effects of pmTBI, and associated sex differences, this thesis utilized both male and female C57B6 mice in a translational preclinical model of pmTBI4,5. Using the closed head injury with long term disorders (CHILD) model of pmTBI we performed whole-cell patch-clamp electrophysiology experiments to investigate intrinsic neuronal excitability changes at acute and chronic timepoints post-injury. Our results indicate increased excitability of hippocampal neurons at post injury day 0 (PI0) in females that appears to resolve by post-injury day 30-35 (PI30) with no recurrent changes at PI1YR. pmTBI also increased ionic dysregulation in an excitotoxicity assay specifically in males at PI30. The increased excitability in females suggests altered hippocampal network connectivity immediately following injury, but due to the sensitive time in pediatric development could have lifelong functional consequences. Further, pmTBI-mediated increases in ionic dysregulation in males suggests that injury could prime neurons to be more vulnerable to secondary injuries or insults later in life.
title: Presentations of Iwahori-Hecke algebras of p-adic GL(2)
Creators: name: De Waal, André
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Hecke Algebras
subject: Iwahori-Hecke
subject: p-adic
subject: Characteristic 0
subject: Non-Archimedean
subject: Education--Mathematics

description: In this thesis we define the Iwahori-Hecke algebra for the algebraic group GL2 over a p-adic field. Besides the definition there are two common presentations used to describe the Iwahori-Hecke algebras in terms of generators and relations. We introduce two more presentations to provide some insight into the structure of the algebra, as well as proving that each of these presentations is isomorphic to the others, mostly through explicit isomorphisms.
La présence intertextuelle d'Ernest Hemingway dans trois romans de Jacques Poulin
Creators: name: Bernovsky, Victor
Publisher: name: University of British Columbia
Year: 2012

description: Our study is inspired by the ideas of the philosopher and literary theorist Mikhail Bakhtin on dialogism and relates to the presence of Ernest Hemingway in the novels of Jacques Poulin: Volkswagen blues, Le vieux chagrin and Les yeux bleus de Mistassini. It analyses the intertextual relationship between the works of Hemingway and Poulin. The concept of dialogism in the work of the Quebec writer manifests itself in the relationship between the discourses and their interdependence. Furthermore, this concept manifests itself in the link between writing and reading, as well as in the personality of the writers/ characters. The discourse on writing crosses the novels in this study and particularly feeds on the intertexts Papa Hemingway, the biography written by A. E. Hotchner, and A Moveable Feast, the quasi-autobiography of Hemingway. We have established a comparison between Volkswagen blues, Le vieux chagrin and Les yeux bleus de Mistassini based upon the forms of references to Hemingway, and determined that the biographical fragments outnumber the paraphrases in each of these novels. A fictional Hemingway intertext of great importance in Poulin’s work is The Old Man And The Sea. Its discourse draws thematic parallels with novels of the Quebec writer. It shares with them the themes of solitude, dignity, affection, friendship, loyalty and the pursuit of happiness. As for the relevance of the Hemingway intertexts in the analysed novels of Poulin, we have determined that Papa Hemingway proves itself as the most useful intertext in the interpretation of Volkswagen blues and Le vieux chagrin. The contribution of Papa Hemingway in the creation of Les yeux bleus de Mistassini is similar to that of A Moveable Feast.
Conditional expectation and Bayes' rule for quantum random variables and positive operator valued measures
Creators: name: Farenick, Douglas
name: Kozdron, Michael J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 47N30 (Primary) 46N50, 81P15, 81P16 (Secondary)

description: A quantum probability measure is a function on a sigma-algebra of subsets of a (locally compact and Hausdorff) sample space that satisfies the formal requirements for a measure, but whose values are positive operators acting on a complex Hilbert space, and a quantum random variable is a measurable operator valued function. Although quantum probability measures and random variables are used extensively in quantum mechanics, some of the fundamental probabilistic features of these structures remain to be determined. In this paper we take a step toward a better mathematical understanding of quantum random variables and quantum probability measures by introducing a quantum analogue for the expected value of a quantum random variable relative to a quantum probability measure. In so doing we are led to theorems for a change of quantum measure and a change of quantum variables. We also introduce a quantum conditional expectation which results in quantum versions of some standard identities for Radon-Nikodym derivatives. This allows us to formulate and prove a quantum analogue of Bayes' rule.
description: v2: 16 pages, 0 figures; substantially revised and updated; shortened significantly with streamlined proofs and removal of several explicit calculations
title: RNA-binding proteins implicated in the anaerobic response of Arabidopsis thaliana and rice
Creators: name: De La Torre Espinoza, Daniela Naomi
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Biology--Molecular

description: Floods and waterlogging significantly impact economically important crops by inducing anaerobic stress, leading to severe agricultural losses. When soils become waterlogged, oxygen levels drop, creating anaerobic conditions that impair root respiration and metabolic functions. Crops can suffer from reduced growth, nutrient uptake inefficiencies, and increased susceptibility to diseases when exposed to anaerobic stress conditions, resulting in decreased yields, and, in severe cases, complete crop failure. The economic ramifications that result from flooding include reduced farm income, higher food prices, and increased costs for recovery and mitigation efforts, thus posing a substantial threat to food security and agricultural sustainability. To further analyze post-transcriptional gene expression under anaerobic stress, the RNA interactome capture (RIC) technique was applied to Arabidopsis roots and rice coleoptiles exposed to anaerobic stress. This advanced method involves UV-crosslinking to stabilize RNA-protein interactions, followed by oligo(dT) capture under denaturing conditions and subsequent protein identification via mass spectrometry. Optimizing the UV crosslinking dosage ensures effective capture of RNA-protein complexes without damaging the tissues. The application of RIC revealed distinct RNA-binding protein (RBP) compositions in both Arabidopsis roots and rice coleoptiles under normal and anaerobic conditions. These findings highlighted significant changes in RNA-protein interactions due to oxygen availability, offering insights into the molecular mechanisms that plants use to adapt to anaerobic stress. This research enhances our understanding of plant resilience and provides potential targets for improving crop tolerance to flooding and waterlogging.
title: Understanding the Mental Health Experiences of Autistic Students in Higher Education: A Mixed Methods Approach
Creators: name: Williamson, Jennifer
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: autism
subject: neurodiversity
subject: mental health
subject: higher education
subject: post-secondary
subject: university
subject: mixed methods
subject: Education--Higher
subject: Psychology
subject: FOS: Psychology

description: Abstract Background: Mental health issues like depression and anxiety are a persistent problem among higher education students, especially students on the autism spectrum. The reasons behind autistic students’ high rates of mental health problems remain unclear, with few studies addressing this topic. However, several factors impacting mental health have been identified within autistic adults and non-autistic higher education students separately, such as perceived campus climate, internalized stigma, and camouflaging (attempts to hide one’s autism). Method: In this exploratory mixed methods study, I combined semi-structured interviews and online surveys to investigate factors associated with mental health among a sample of autistic students attending the University of Calgary (UCalgary). Quantitative analyses included collecting descriptive statistics from the survey and running correlations between mental health outcomes (e.g., stress, quality of life) and potential factors (e.g., campus climate, stigma, camouflaging), while qualitative analysis consisted of reflexive thematic analysis of interview data to understand participants’ lived experiences with mental health. Results: Based on 12 surveys and 10 interviews, several key findings emerged. First, participants reported high levels of depression, anxiety, and stress. Second, autism-specific quality of life was negatively correlated with stigma but positively correlated with camouflaging and campus climate; no other correlations between factors and mental health outcomes reached significance, although stigma and camouflaging had a strong negative correlation. Finally, three key themes were developed from the interviews: 1) autistic students have heterogeneous experiences with mental health; 2) mental health is affected by personal autism identity and societal-level messages about autism, including stigma; and 3) the UCalgary environment has both positive (e.g., providing autism-specific supports) and negative (e.g., too much sensory input) influences on mental health. Collectively, these findings support past literature and underscore the need to increase mental health support for autistic students. Conclusions and Impact: These initial findings highlight how a variety of individual and environmental factors contribute to autistic students’ mental health. Addressing these factors can create more inclusive environments at higher education institutions like UCalgary, thus fostering well-being and academic success for autistic and non-autistic students alike.
Baryon as dyonic instanton
Creators: name: Gorsky, A.
name: Krikun, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the baryon in the holographic QCD framework and focus on the role of the bifundamental scalar field, realizing chiral symmetry breaking. We suggest the interpretation of a baryon as a dyonic instanton within the Atiyah-Manton-like approach for the flavor gauge group in the peculiar cylindrical ansatz in five-dimensional theory. Our approach provides the new mechanism of the stabilization of the baryon size.
description: 19 pages, 2 figures, v2: version to be published in PRD. Introduction improved, references added, typos corrected
Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period
Creators: name: Gaspe, M. Sol
name: Provecho, Yael M.
name: Fernández, María P.
name: Vassena, Claudia V.
name: Santo Orihuela, Pablo Luis
name: Gürtler, Ricardo E.
Publisher: name: Columbia University
Year: 2018
Subjects: Chagas' disease
Vector control
Pyrethroids
Insecticides
Medicine, Preventive

description: Background
Rapid reinfestation of insecticide-treated dwellings hamper the sustained elimination of Triatoma infestans, the main vector of Chagas disease in the Gran Chaco region. We conducted a seven-year longitudinal study including community-wide spraying with pyrethroid insecticides combined with periodic vector surveillance to investigate the house reinfestation process in connection with baseline pyrethroid resistance, housing quality and household mobility in a rural section of Pampa del Indio mainly inhabited by deprived indigenous people (Qom).

Methodology/Principal findings
Despite evidence of moderate pyrethroid resistance in local T. infestans populations, house infestation dropped from 31.9% at baseline to 0.7% at 10 months post-spraying (MPS), with no triatomine found at 59 and 78 MPS. Household-based surveillance corroborated the rare occurrence of T. infestans and the house invasion of other four triatomine species. The annual rates of loss of initially occupied houses and of household mobility were high (4.6–8.0%). Housing improvements did not translate into a significant reduction of mud-walled houses and refuges for triatomines because most households kept the former dwelling or built new ones with mud walls.

Conclusions/Significance
Our results refute the assumption that vector control actions performed in marginalized communities of the Gran Chaco are doomed to fail. The larger-than-expected impacts of the intervention program were likely associated with the combined effects of high-coverage, professional insecticide spraying followed by systematic vector surveillance-and-response, broad geographic coverage creating a buffer zone, frequent housing replacement and residential mobility. The dynamical interactions among housing quality, mobility and insecticide-based control largely affect the chances of vector elimination.
Parmelinella amazonica A. S. Rodrigues, A. P. Lorenz & Canêz
Creators: name: R, Jeanne dos
name: Silva, eis
name: Aptroot, André
name: E, Marcela
name: S, ugenia da
name: Cáceres, ilva
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Lecanoromycetes
Lecanorales
Parmeliaceae
Parmelinella
Parmelinella amazonica

description: Parmelinella amazonica (Nyl.) A.S.Rodrigues, A.P.Lorenz & Canêz
PREVIOUS REPORT. — Mistry (1998).
NEW REPORT. — Parque Nacional de Brasília, on bark, leg. J.A.R. Silva, ISE 53586.
description: Published as part of R, Jeanne dos, Silva, eis, Aptroot, André, E, Marcela, S, ugenia da & Cáceres, ilva, 2023, Lichens from dry central Brazil: a checklist of lichenized fungi from Distríto Federal and Goiás, pp. 117-133 in Cryptogamie, Mycologie 20 (9) on page 122, DOI: 10.5252/cryptogamie-mycologie2023v44a9, http://zenodo.org/record/8434271
Perception of Kinship Structure Reflected in the Adnjamathanha Pronouns
Creators: name: Hercus, Luise (Ed.)
name: White, Isobel (Ed.)
Publisher: name: Pacific Linguistics
Year: 1973

description: PERCEPTION OF KINSHIP STRUCTURE REFLECTED IN THE ADNJAMATHANHA PRONOUNS. 47 1. INTRODUCTION 49ILLUSTRATIONS: 1. Andrew and Dolly Coulthard 2. May Wilton 3. Jack Coulthard 4. Sydney and Annie Ryan 5. Alice Oldfield 6. Barney Coffin 2. THE ADNJAMATHANHA AND THEIR KINSHIP AND MARRIAGE SYSTEM 50 3. THE PERCEPTION OF KINSHIP STRUCTURE 53 4. PRONOUN FORMS 57 5. COLLECTIVE NOUNS 60 6. THE GEOGRAPHICAL EXTENT OF THE ADNJAMATHANHA PRONOUN SYSTEM 61 7. THE FURTHER EXTENT OF COMPLEX PRONOUN SYSTEMS 62 a. in other parts of Australia b. Southern and Eastern Aranda c. Arabana - Waŋgaŋuru and the Dieri Language Group 8. NOTES 67FIGURES AND TABLES 68Figure 1 The Ŋapaḷa and Ubmaḷi Relationships facing page 68Table 1 Adnjamathanha Kinship Terminology from the point of view of a Man 69Table 2 Adnjamathanha Kinship Terminology from the point of view of a Woman 71MAPS 73Map 1. Distribution of Birth-order Names 73Map 2. Distribution of Special Pronouns in South Central Australia 75