cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam
Creators: name: Tran, Thanh-Nha
name: Sichaem, Jirapast
name: Nguyen, Van-Kieu
name: Nguyen, Huu-Hung
name: Cao, Truong-Tam
name: Nguyen, Thi-Phuong
name: Vo, Van-Giau
name: Niamnont, Nakorn
name: Nguyen, Ngoc-Hong
name: Duong, Thuc-Huy
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 60506 Virology

description: Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent-atisane compounds, ent-3α-acetoxy-16β,17,18-trihydroxyatisane (1) and ent-3α,14,16β,17-tetrahydroxyatisane (2) together with three known compounds, 20-deoxy-16-hydroxyingenol (3), ent-14[S],16α,17-trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1–5 were evaluated for α-glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against α-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 µM, respectively. None showed activity in cytotoxicity assay.
title: Κατανάλωση κρέατος και εμφάνιση καρκίνου στον άνθρωπο
title: Meat consumption and the occurrence of cancer in humans
titleType: AlternativeTitle
Creators: name: Μπιρμπίλη, Μαρία-Δήμητρα
name: Στεφανίδου, Μαρία-Βασιλική
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Κρέας
Καρκίνος

description: Το κρέας αποτελεί βασικό συστατικό της διατροφής του ανθρώπου, παρέχοντάς του απαραίτητα θρεπτικά συστατικά, που είναι σημαντικά για την ανάπτυξη και τη φυσιολογική λειτουργία του οργανισμού. Ωστόσο, ορισμένες μελέτες αναφέρουν, ότι υπάρχει σύνδεση της εμφάνισης κάποιων ασθενειών με την κατανάλωση κρέατος, γεγονός που προκαλεί ανησυχία στους ανθρώπους. Οι ασθένειες με τις οποίες βρέθηκε να συνδέεται η κατανάλωση κρέατος είναι τα καρδιαγγειακά νοσήματα, ο καρκίνος και ο διαβήτης τύπου 2. O καρκίνος είναι μία από τις κύριες αιτίες νοσηρότητας και θανάτου σε όλο τον κόσμο και η εύρεση των αιτιών που προκαλούν την έναρξη της καρκινογένεσης στον ανθρώπινο οργανισμό είναι δύσκολη. Όσον αφορά τη συσχέτιση της διατροφής με την εμφάνιση καρκίνου, αναφέρεται σε κάποιες μελέτες ότι η κατανάλωση κόκκινου και επεξεργασμένου κρέατος βρέθηκε να συνδέεται κυρίως με τον καρκίνο του παχέος εντέρου και ενδεχομένως και με άλλες μορφές καρκίνου. Όμως υπάρχουν και έρευνες που αντικρούουν αυτά τα ευρήματα. Έχουν αναφερθεί κάποιοι μηχανισμοί που μπορούν να εξηγήσουν τη σύνδεση του κρέατος με τον καρκίνο, όπως η παρουσία αιμικού σιδήρου στα κόκκινα κρέατα, οι ετεροκυκλικές αμίνες (HCA) και οι πολυκυκλικοί αρωματικοί υδρογονάνθρακες (PAH) που παράγονται κατά το μαγείρεμα σε υψηλές θερμοκρασίες και οι Ν-νιτροζο ενώσεις (NOC) που σχηματίζονται είτε ενδογενώς στον οργανισμό είτε προσλαμβάνονται μετά από έκθεση σε εξωγενείς πηγές. Τελευταία, γίνεται όλο και πιο συχνή η τάση των καταναλωτών να ακολουθούν χορτοφαγική διατροφή ώστε να αποφευχθούν οι πιθανές αρνητικές επιδράσεις της κατανάλωσης του κρέατος. Με τη χορτοφαγική δίαιτα ωστόσο μπορεί να προκληθούν κάποια προβλήματα υγείας λόγω της πιθανής ανεπάρκειας κάποιων θρεπτικών συστατικών. Στόχος της παρούσας εργασίας ήταν να μελετηθεί η σχέση μεταξύ της κατανάλωσης κρέατος και της πιθανότητας κινδύνου εμφάνισης καρκίνου στον άνθρωπο.
Dysregulation of cytokine production with aging
Creators: name: Spencer, Nina Freund Lear
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Aging represents a clinical situation in which there is a decline in many physiological functions. The focus of this work centers around changes within the immune system. Fidelity of the immune system is known to depend upon the proper functioning of a subtle and well-balanced network of cytokines that control the survival, proliferation, and differentiation of lymphocytes and other lymphoid cells. T cells, B cells, and macrophage cell populations from aged individuals have been shown to demonstrate alterations in the inducibility and production of certain cytokine species. The work contained within this dissertation demonstrates a dysregulation in the production of interleukin (IL-10) by B cells and IL-12 by macrophages in aged mice. These cytokines, based on their pleiotropic activities, might be contributing significantly to the aging phenotype. Furthermore, experiments contained within these chapters provide evidence, for the first time, that macrophages appear to be the cell type primarily responsible for the dysregulation of cytokines observed in aging.  A common denominator between the species of macrophage cytokines observed to be dysregulated with aging is their inducibility by the transcription factor nuclear factor (NF)-kB. Evidence is provided within Chapter 4 of this thesis that there are elevations in active nuclear NF-kB in splenocytes obtained from aged animals. This observation suggests that there is some common factor responsible for the dysregulation of cytokines in aging and the subsequent effect their presence has on various physiological functions.  It has been established that elevations in reactive oxygen intermediates (ROIs) and lipid peroxides occur with aging.  This dissertation demonstrates in Chapter 4 that antioxidant treatment of aged animals markedly reduces nuclear NF-kB activity, lowers lipid peroxidation, and eliminates the abnormal production of interleukin-6 and other aberrantly expressed molecules commonly observed in these animals. This observation provides evidence, for the first time, for a molecular explanation of the presence of dysregulated cytokines in old age.
Sonnenfleckenzeichnung Nr. 22864.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.08.1968, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Effects of an individual prescription diet during pregnancy on infant outcome: Phase II
Creators: name: La Malfa, Toni Vi
name: Ryan, Barbara J.
Publisher: name: University of Utah
Year: 2012
Subjects: Pregnancy - Nutritional aspects

description: The purpose of this research was to identify the effects of an individual prescription of protein and kilocalories during pregnancy on infant outcomes. The specific aim of the study was to compare quantitatively the relationship between the maternal independent variable of adequate and inadequate levels of protein and kilocalories ingested during pregnancy and the dependent variable of infant outcome. The following categories of infant outcomes were measured: morbidity and mortality, anthropometric data, behavioral assessment, Apgar score and gestational age assessment. This research is an extension of a previous study. The results of that research and the present findings have been combined for comparison and analysis. Forty-three newborns were assigned to either an adequate group or inadequate group using the Static Group Comparison design. This design compared newborns of mothers who ate adequately and those who did not. Differences were identified between infant outcomes for those adequate group"" mothers whose average daily ingestion of both protein and kilocalories was greater than or equal to 85% of the prescription when compared with infant outcomes for those ""inadequate group"" mothers whose average daily ingestion of both protein and kilocalories was less than 85% of the prescription. Differences between the adequate newborn group (N^ = 18) and the inadequate newborn group (N = 25) included significantly greater birthweights for infants of mothers in the adequate group, higher birth-weight percentiles, and higher habituation scores. Other results suggestive of significance included 5 minute Apgar scores and infant behavioral assessment scores. These findings support the positive effects of adequate maternal intake of protein and kilocalories on infant outcomes.""
Generation of Independent Complement Receptor 1 and Complement Receptor 2 Knockout Mice and Defining the Role of Complement Receptor 1 in Humoral Immunity
Creators: name: Donius, Luke Robert
Publisher: name: University of Utah
Year: 2014

description: Complement receptor (Cr)1 and Cr2 have long been studied in relation to humoral immunity. These receptors are alternative splice variants of the murine Cr2 gene, and all previous investigations of the effect of Cr1 and Cr2 on humoral immunity have been conducted utilizing mouse models deficient in both Cr1 and Cr2. To date, very little effort has been taken to delineate the functional roles of each receptor. The known molecular differences and independent transcription of Cr1 and Cr2 suggest a functional significance for each of these that should not be ignored. Additionally, I discovered that Cr1 and Cr2 are differentially expressed by follicular dendritic cells (FDCs) and B cells. It is shown here that B cells predominantly express Cr2, while Cr1 is the near exclusive Cr2 product on FDCs. To investigate the independent roles of Cr1 and Cr2 in the context of an immune response, I generated two new mouse strains: Cr1KO and Cr2KO. The predominance of Cr1 on FDCs led to the hypothesis that Cr1 primarily functions in FDC promotion of germinal center (GC) reactions, which is likely mediated by the known complement-dependent deposition of immune complexes in follicles. Analysis of these new strains demonstrated that Cr1 and Cr2 have marked differences in their function in humoral immunity. In many cases, the B cell responses which are decreased in the Cr1/2- deficient mouse are unaffected in the Cr1-deficient mouse. It is shown that Cr1- deficiency on FDCs results in a significant reduction in the maintenance of GC B cells and memory B cell production. Intriguingly, classically GC-independent responses, such as antigen-specific IgM and IgM memory B cells, are also reduced. However, B cell responses that cannot proceed through germinal centers, notably T-independent B cell responses, are not affected by Cr1-deficiency. In total, this work defines the Cr1KO and Cr2KO mouse lines as new models for the study of Cr1 and Cr2 in humoral immunity. In addition to its use in the study of the function of Cr1, the Cr1KO mouse is an invaluable tool in the investigation of GC biology.
Sonnenfleckenzeichnung Nr. 22881.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.08.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Segmentation of neurons from electron microscopy images
Creators: name: Jurrus, Elizabeth
Publisher: name: University of Utah
Year: 2012
Subjects: Artificial neural networks
Connectomics
Electron microscopy
Image processing
Machine learning
Segmentation

description: Neuroscientists are developing new imaging techniques and generating large volumes of data in an effort to understand the complex structure of the nervous system. The complexity and size of this data makes human interpretation a labor intensive task. To aid in the  analysis, new segmentation techniques for identifying neurons in these feature rich datasets are required. However, the extremely anisotropic resolution of the data makes segmentation and tracking across slices difficult. Furthermore, the thickness of the slices can make the membranes of the neurons hard to identify. Similarly, structures can change significantly from one section to the next due to slice thickness which makes tracking difficult. This thesis presents a complete method for segmenting many neurons at once in two-dimensional (2D) electron microscopy images and reconstructing and visualizing them in three-dimensions  (3D). First, we present an advanced method for identifying neuron membranes in 2D, necessary for whole neuron segmentation, using a machine learning approach. The method described uses a series of artificial neural networks (ANNs) in a framework combined with a feature vector that is composed of image and context; intensities sampled over a stencil neighborhood.  Several ANNs are applied in series allowing each ANN to use the classification context; provided by the previous network to improve detection accuracy. To improve the  membrane detection, we use information from a nonlinear alignment of sequential learned membrane images in a final ANN that improves membrane detection in each section. The final output, the detected membranes, are used to obtain 2D segmentations of all the neurons in an image. We also present a method that constructs 3D neuron representations by formulating the problem of finding paths through sets of sections as an optimal path computation, which applies a cost function to the identification of a cell from one section to the next and solves this optimization problem using Dijkstras algorithm. This basic formulation accounts for variability or inconsistencies between sections and prioritizes cells  based on the evidence of their connectivity. Finally, we present a tool that combines these techniques with a visual user interface that enables users to quickly segment whole neurons in large volumes.
Constituent composition of the essential oils from some species of the genus Saussurea DC
Creators: name: Avdeeva, Elena
name: Reshetov, Yaroslav
name: Domrachev, Dmitry
name: Gulina, Ekaterina
name: Krivoshchekov, Sergei
name: Shurupova, Margarita
name: Brazovskii, Konstantin
name: Belousov, Mikhail
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The genus Saussurea DC is well known for its rich chemical composition and wide range of biological activities. Although content and biological effects of major chemical components are thoroughly studied, the composition and concentrations of minor constituents, such as essential oils, still remains unclear. In total, 62 different chemical compounds have been identified in the essential oils from S. controversa, S. latifolia, S. parviflora and S. salicifolia using a gas chromatography–mass spectrometry method. The essential oils include 1–5% of linalool, 2–7% of eudesmol and oxygen-containing sesquiterpenoids: 7–25% of caryophyllene oxide, 4–5% of spathulenol, 4–6% of humulene-6.7-oxide. The presence of sesquiterpenoids can be considered as a chemotaxonomic feature of the studied species of Saussurea DC. The essential oils can be candidates for new anti-inflammatory, analgesic and anti-tumor drugs due to relatively high concentration of caryophyllene oxide.
Sonnenfleckenzeichnung Nr. 22954.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.12.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Callistethus marginatus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Callistethus
Callistethus marginatus

description: § Callistethus marginatus (Fabricius, 1792)
Melolontha marginata Fabricius 1792: 164 (none)
= Melolontha annulata Germar 1824: 121 (U.S.A.)
Distribution. Brazil: Blackwelder 1944: 244 (as Anomala marginata). Venezuela: Ohaus 1897: 419 (as Anomala marginata). “Amazon Basin”: Ohaus 1897: 419 (as Anomala marginata); Machatschke 1972: 174. Other: Fabricius 1792: 164 (none - as Melolontha marginata); Germar 1824: 121 (U.S.A. - as Melolontha annulata); Ohaus 1897: 419 (“Amazon Basin”–North America - as Anomala marginata); Blackwelder 1944: 244 (Central and South America - as Anomala marginata); Machatschke 1972: 174 (“Amazon Basin”–North America).
Note 1. Callistethus marginatus is described as Melolontha marginata in Fabricius (1792: 164), while Strigoderma marginata is described as Melolontha marginata in Olivier (1789: 70). We are unaware whether this homonymy has already been resolved. If it is still unresolved, it seems logical to keep the older S. marginata (Olivier, 1789) as a valid name and use as a replacement name for its junior homonym the name M. annulata Germar, 1824 (p. 121), which is found to be a synonym of M. marginata Fabricius, 1792 in Burmeister (1844: 266). We have refrained from doing so because we have not verified the validity of the synonymy of M. marginata Fabricus, 1792 with M. annulata Germar, 1824, while we are also unsure if older synonymies or homonymies of these names exist.
Note 2. Although we have found no records or specimens of Callistethus marginatus for the research area, we have elected to include this species in this checklist because of its proximity to the research area and to draw some attention to the nomenclatural issue mentioned above. See also at Strigoderma marginata.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 120-121, DOI: 10.5281/zenodo.3678492
A new diterpenoid from the leaves of Phyllanthus acidus
Creators: name: Duong, Thuc-Huy
name: Nguyen, Tien Trung
name: Phan, Cam-Tu Dang
name: Nguyen, Vu-Duy
name: Nguyen, Hoang-Chuong
name: Dao, Thi-Bich-Ngoc
name: Mai, Dinh-Tri
name: Niamnont, Nakorn
name: Tran, Thi-Ngoc-Mai
name: Sichaem, Jirapast
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A new diterpenoid, phyllane C (1), along with three known compounds, ovoideal E (2), spruceanol (3), and fluacinoid B (4) were isolated from the leaves of Phyllanthus acidus growing in Thailand. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods were applied to define the relative configuration of 1. Compound 3 showed a weak cytotoxicity against K562 cell line (IC50 41.9 ± 2.31 µg/mL).
Veteran status, race, and labor mobility in the United States
Creators: name: Doetsch, Ethan
Publisher: name: University of Utah
Year: 2012
Subjects: Great migration
Race
Veterans
WWI veterans

description: Using a new, representative, longitudinal microdata sample that observes native-born white and black men in 1917 and in 1930 in rich detail, this dissertation investigates the determinants of World War I (WWI) draft probability, the effects of WWI military service on subsequent occupational and geographic mobility, racial variations in the effect of WWI service on labor mobility, and racial variation in Southern out-migrant self-selection during the Great Migration period. Examining how family structure, literacy, occupation, and race affected a man's probability of conscription during WWI, this dissertation finds that inductees were more literate and healthier than the rest of the draft pool. Marriage and having dependents reduced a man's probability of being drafted. Having an agricultural occupation reduced the probability of being drafted for Whites, but not Blacks. Overall, the draft mechanism seems to have functioned as intended and positively selected inductees. This dissertation also finds that the effect of WWI military service varied substantially by race. Service slightly increased the probability of holding a white-collar or skilled blue-collar occupation by 1930, controlling for observed biases in the assignment of veteran status. White veterans who held such jobs before the war were less likely to end up in unskilled labor occupations in 1930. Skilled White soldiers held skilled jobs during the war where they could accumulate experiences transferable to civilian labor markets. Black veterans enjoyed no such protections from downward occupational pressures. WWI service did not offer upward occupational mobility to lowskilled workers or a transition out of agriculture for farmers and farm laborers. White veterans were more likely to make an interstate or interregional geographic move after the war, but Black veterans had the same rates of migration as Black nonveterans. Finally, this study observes black and white Southern out-migrants and nonmigrants before and after migration. Compared with their sending population, Black migrants were more literate and disproportionately from urban areas. Black migrants were more likely to have left from nonfarm occupations in the South and, among nonfarm occupations, professional blacks were more likely to leave. White migrants were more literate than their sending population, but otherwise representative.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.09.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 22935.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.10.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Metabolite profiling of Andrographis paniculata leaves and stem extract using UHPLC-Orbitrap-MS/MS
Creators: name: Rafi, Mohamad
name: Karomah, Alfi Hudatul
name: Heryanto, Rudi
name: Septaningsih, Dewi Anggraini
name: Kusuma, Wisnu Ananta
name: Amran, Muhammad Bachri
name: Rohman, Abdul
name: Prajogo, Bambang
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Andrographis paniculata is known as the king of bitter and it has been widely used as a medicinal plant. The properties of A. paniculata are generally determined by the metabolite composition, which may be influenced by several factors, one of which is the part of the plant extracted. The objectives of this research are to identify putatively the metabolite composition of the stem and the leaves extracts using LC-MS/MS and classify them using PCA. The stem and the leaves samples were separated and extracted using sonication with 70% ethanol. A total of 31 metabolite compounds has been putatively identified. All compounds were identified in the stem and the leaves extracts, which only differed in their intensity. These metabolite compounds were divided into diterpene lactones, flavonoids, and phenolic acid groups. By using the peak intensities of the 18 compounds identified, the leaves and stem extracts were grouped using PCA.
Sonnenfleckenzeichnung Nr. 22875.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.08.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Callistethus microcephalus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Callistethus
Callistethus microcephalus

description: Callistethus microcephalus (Burmeister, 1844)
Anomala (Anomala) microcephala Burmeister 1844: 264 (Colombia)
= Anomala atropurpurea Ohaus 1897: 414 (French Guiana)
= Anomala aequatorialis huanapensis Ohaus 1908: 300 (Peru)
Distribution. French Guiana: Ohaus 1897: 414 (as Anomala atropurpurea); Blackwelder 1944: 243 (as Anomala atropurpurea); Machatschke 1972: 176 (as C. atropurpureus); Soula 2010a: 53 (as C. atropurpureus). Brazil: Ohaus 1897: 414 (as Anomala microcephala). Venezuela: Blackwelder 1944: 244 (as Anomala microcephala). Other: Burmeister 1844: 264 (Colombia - as Anomala (Anomala) microcephala); Ohaus 1897: 414 (Colombia - as Anomala microcephala), 1908: 300 (Peru - as Anomala aequatorialis huanapensis); Blackwelder 1944: 243, 244 (Peru - as Anomala aequatorialis huanapensis; Colombia - as Anomala microcephala); Machatschke 1972: 176, 177 (Peru - as C. aequatorialis huanapensis; Colombia - as C. microcephalus).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 121, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung Nr. 22925.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.10.1968, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Rapid throughput solubility screening assay development and its applications in preformulation
Creators: name: Guo, Jeremy
Publisher: name: University of Utah
Year: 2012
Subjects: Analysis
Drug Development
Drug Solubility

description: Drug solubility is an important physicochemical property for orally administered drugs because it can significantly influence drug dissolution and absorption profiles. Investigative drugs need to have solubility profiles established as early as possible because poor solubility may result in incomplete dissolution and low bioavailability. The limited quantities of drug and time in early product development, often delay such evaluation, resulting in unexpected challenges in later stage. This dissertation describes a new solubility screening method based on the 96-well plate format that minimizes drug material requirements while returning accurate solubility information timely. The method was first applied to estimate the salt solubility parameter, KSP. High concentration drugs were initially dissolved in DMSO, and robotically distributed into 96-well plates. DMSO was evaporated, and drugs were equilibrated in various acids at different concentrations to yield final total drug concentrations of about 2.5 mM. All wells were filtered, and supernatants from wells with precipitates were subjected to rapid gradient HPLC analysis. An iterative procedure was employed to calculate apparent KSP values based on mass and charge balance equations. A correlation coefficient of greater than 0.975 for 8 drugs totaling 16 salts was reported. Reproducibility was better than 10%. The dynamic range of the assay could be expanded by adjusting drug and counter-ion concentrations. The method was then used to evaluate the solubilities of Biopharmaceutic Classification Scheme (BCS) class II drugs in animal and simulated human GI fluids. The goal was to establish correlates between in vitro and in vivo drug solubility in the GI tract. Four BCS class II drugs with solubilities ranging from a few ug/mL to over 100 ug/mL were evaluated in simulated GI fluid in both fasted and fed conditions. Method reproducibility was within 15% relative standard deviation. Solubility values from the screening method correlated well with literature values. Effects of commonly used pharmaceutical solubilizers (PEG 400, Tween 80, hydroxypropyl-?cyclodextrin) on danazol, mefenamic acid, phenytoin and griseofulvin in simulated GI fluids containing bile salts (which are also solubilizers) were also assessed. At typical concentrations (>5%), PEG 400's solubilization predominated over bile salt. Likewise, Tween 80 (surfactant) was more effective than bile salts. Addition of hydroxypropyl-?-cyclodextrin actually reduced solubility, this was attributed to competitive binding from bile salt monomers and drug molecules to hydroxypropyl-?-cyclodextrin. We believe that this 96-well format-screening assay is a powerful tool for pre-formulation researchers.
Phytochemicals from Calophyllum macrocarpum Hook.f. and its cytotoxic activities
Creators: name: Karunakaran, Thiruventhan
name: Firouz, Noor Syarafana
name: Santhanam, Rameshkumar
name: Jong, Vivien Yi Mian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Species from the Genus Calophyllum are rich source for bioactive phenolic compounds such as coumarins and xanthones. Phytochemical study carried out on the plant, Calophyllum macrocarpum has led to the isolation of three known prenylated xanthones, ananixanthone (1), trapezifolixanthone (2) and 8-deoxygartanin (3) with two common triterpenoids, stigmasterol (4), and friedelin (5). The structures of these compounds were identified and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1 and 2 as well as the extracts were tested against HeLa Chang liver and HEK-293 cell lines. Compound 1 exhibited appreciable cytotoxicity with the IC50 value of 11.08 ± 3.09 µM against HeLa Chang liver cell line and moderate cytotoxicity against HEK-293 cell line while compound 2 showed limited toxicity against these two cell lines.
Sonnenfleckenzeichnung Nr. 22937.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.10.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 22965.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.12.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: A Consumer Behavior and Service Marketing Perspective on Smart Technology : Understanding smart consumption experiences, their contexts, consumer trust, and smart service encounters
Creators: name: Föhr, Jonas
Publisher: name: University of Bayreuth
Year: 2022
Subjects: subject: Smart Technology
subject: Alexa
subject: Smart Services
subject: Smart Device
subject: Trust in Technology
subject: Voice Interaction
subject: Artificial Intelligence
subject: 330

description: Smart (home) devices, often comprising some degree of artificial intelligence, have recently gained centrality in consumers’ lives. Likewise, marketing research shows growing interest in consumers’ use of smart technology, which has resulted in a plethora of works on the topic. However, extant research projects have tended to either take a prophetic, future-oriented or prematurely specific stance. Hence, a substantial theoretical understanding of consumption experiences with smart technology is as of yet missing. Adopting a consumer behavior and service marketing perspective, this thesis aims to close this research gap. Across four research projects, both conceptual and empirical, this dissertation first delimits and specifies the phenomenon of smart digital consumption, before analyzing the transformative impact of smart devices on consumers’ domestic contexts. Additionally, this thesis investigates how consumers build and maintain trust in their smart devices (in this case, smart voice-interaction technologies), and finally examines the hybrid influence of digital and analog contexts on smart service value generation. The findings of this thesis suggest that if marketing researchers aim to contribute to meaningful knowledge about consumers’ smart technology use and want to generate original research results, they first need to establish a more contextual understanding of smart technologies as such and their impact on consumption experiences. To stimulate scientific progress, this thesis concludes by identifying avenues for future research.
Operational performance of the CMS silicon strip detector during Run 3
Creators: name: Shvetsov, Ivan
Publisher: name: Scuola Internazionale Superiore di Studi Avanzati (SISSA)
Year: 2024

description: The CMS silicon strip tracker, consisting of 15148 silicon modules with a 198 m$^2$ active area, has been successfully taking data in LHC Run 1 and Run 2. After the second long shut-down period from the end of 2018, the detector resumed operations in summer 2021 and will be operational till the end
of LHC Run 3, before the HL-LHC upgrade. The performance of the detector during Run 3 will be discussed, with particular emphasis on the (expected) changes in detector performance with increasing irradiation. The performance of the detector during the early 2023 collisions will also be presented.
Development of assays for measurement of blocking and modulating autoacetylcholine receptor antibodies using rhabdomyosarcoma cells
Creators: name: Astill, Mark E.
Publisher: name: University of Utah
Year: 2012
Subjects: Autoantibodies
Acetylcholine - Receptors
Autoimmune diseases
Myasthenia gravis

description: Autoimmune pathologies result from an immune response against autologous antigens.  In myasthenia gravis autoantibodies are directed toward acetylcholine receptors (AChR) causing a disruption in neuromuscular transmission.  Although testing is available for measurement of a heterogeneous binding autoantibody population, recent evidence suggests that specific modulating and blocking antibodies correlate more closely with disease status.  General AChR binding antibodies are measured with 125I-bungarotoxin (125I-aButx) and solubilized human AChR in an immunoprecipitation RIA.  Specific blocking and modulating antibodies are measured with a sequential RIA using rhabdomyosarcoma (RD) cells.  The anchorage dependent cells are grown in vitro, enzymatically released and used as a "free" suspension.  Expression of receptor was measured as was equivalence of RD-AChR to other sources.  Performance of the specific systems was evaluated.  Over 100 samples submitted for binding were also tested for blocking and modulating antibody.  HPLC of endocytosed 125I1Vutx and AChR binding ability was measured.  Binding antibody was also measured in autoimmune thyroid receptor antibody (TRAB) sample.  Approximately 2.2 x 10(6) RD cells were used per test at a ratio of 10 mL patient sera/million cells.  Maximum radiolabel binding to cells was observed in approximately 4 hours with a Kd of 5.3 x 10-(10)M.   Within-assay imprecision was less than 14% and 18% for blocking and modulating assays respectively.  Of the 107 samples tested, 57 were negative for all three antibodies and 31 testes positive.  Using the binding assay only, 32% of the population were classified positive.  When specific antibody tests were included 46% were positive.  Endocytosed radiolabel lost 80% of receptor binding capacity and may be altered in size TRAB samples appeared to have higher AChR-binding than controls.  The AChR binding assays is not capable of measuring all relevant antoantibodies.  The RD assays proved added capability.  However, there remain autoantibodies not measured by any of these assays.  Future studies with clinically defined samples are necessary.
Inverse kinematics of the KUKA LBR iiwa R800 (7 DOF)
Creators: name: Doliwa, Sebastian
Publisher: name: Zenodo
Year: 2020
Subjects: Inverse Kinematics
KUKA LBR iiwa R800
7 degrees of freedom (7 DOF)

description: This document describes the calculation of the inverse kinematics of the KUKA LBR iiwa R800 which has 7 DOF. Furthermore, it provides all required mathematical steps to get all joint angles for a specific gripper position and to deal with the extra degree of freedom of the robot arm.
Callistethus sulcipennis
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Callistethus
Callistethus sulcipennis

description: Callistethus sulcipennis (Laporte, 1840)
Euchlora sulcipennis Laporte 1840: 136 (French Guiana)
= Anomala surinama Burmeister 1844: 538 (“Guianas”)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini, Arapahu Resort, (3°27′N, 57°37.5′W). 12/ 15-III-2011. A. J. Hielkema. On HPL.); NZCS. French Guiana: Laporte 1840: 136 (as Euchlora sulcipennis); Blackwelder 1944: 245 (as Anomala sulcipennis); Machatschke 1972: 176; Soula 2010a: 53. “Guianas”: Burmeister 1844: 538 (as Anomala surinama); Machatschke 1972: 176; Soula 2010a: 53. Brazil: Blackwelder 1944: 245 (as Anomala sulcipennis). “Amazon Basin”: Machatschke 1972: 176.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 121, DOI: 10.5281/zenodo.3678492
Enhancing reliability in device-free localization
Creators: name: Maheshwari, Manas
Publisher: name: University of Utah
Year: 2012
Subjects: Device free localization
Localization
Security
Sensor networks
Tracking

description: Location of an object or person in in-door environments is a vital piece of in-formation. Traditionally, global positioning system-based devices do an excellent  job in providing location information but are limited in in-door environments due to lack of an unobstructed line of sight. Wireless environments, with their extreme  sensitivity to the positioning of objects inside them, provide excellent opportunities for obtaining location information of subjects. Received signal strength (RSS) based localization methods attract special attention as they can be readily implemented with "off-the-shelf" hardware and software. Device-free localization (DFL) presents a new and promising dimension in RSS-based localization research by providing a non-intrusive method of localization. However, existing RSS-based localization schemes assume a fixed or known transmit power. Any unexpected change in transmit power,  not known to the receivers in the wireless network, can introduce errors in location estimate. Previous work has shown that meticulously planned power attacks can  result in expected errors, in location of a transmitting sensor, in excess of 18 meters for an area of 75 X 50 m2. We find that the localization error in DFL can increase  by four-fold when under power attack of 15 dB amplitude by multiple adversaries.  Certain nonadversarial circumstances can also lead to unexpected changes in transmit power which would result in increased localization error. In this thesis, we focus on detection and isolation of wireless sensor nodes in a network which vary their transmit power to cause unexpected changes in RSS measurements and lead to increased localization errors in DFL. In the detection methods presented in this thesis, we do not require a training phase and hence, our methods are robust for use in dynamic environments where the training data may get obsolete frequently. We present our work with special focus on DFL methods using wireless sensor networks. However, the methods developed are generic and can be easily extended to active localization methods using both wireless sensor networks (WSN) and IEEE 802.11 protocols. To evaluate the effectiveness of our detection method, we perform extensive experiments  in indoor settings using a network of 802.15.4 (Zigbee) compliant wireless sensor nodes and present evaluation results in the form of average detection rate, ROC  curves, probability of missed detection and false alarm.
Sonnenfleckenzeichnung Nr. 22953.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.12.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel