cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Human DNA Repair Excision Nuclease: ANALYSIS OF THE ROLES OF THE SUBUNITS INVOLVED IN DUAL INCISIONS BY USING ANTI-XPG AND ANTI-ERCC1 ANTIBODIES
Creators: name: Matsunaga, Tsukasa
name: Sancar, Aziz
name: Reardon, Joyce T.
name: Mu, David
name: Park, Chi Hyun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Human DNA repair excision nuclease removes DNA damage by incising on both sides of the lesion in a precise manner. The activity requires participation of 16-17 polypeptides. Of these, the XPF.ERCC1 complex and XPG were predicted to carry the nuclease active sites based on studies with the recombinant proteins and the yeast homologs of these proteins. Furthermore, recent work with model (undamaged) substrates have led to predictions of the roles of these proteins in incising 5' or 3' to the lesion. We have used damaged DNA substrates and antibodies to XPG and ERCC1 to test these predictions. Our results reveal that anti-XPG antibodies change the site of 3' incision and at high concentration inhibit the 3' incision without significantly affecting the 5' incision, indicating that XPG makes the 3' incision and further that under this condition 5' incision can occur without 3' incision. In contrast, anti-ERCC1 antibodies inhibit both the 3' and 5' incisions. Using a defined system for excision repair we also demonstrate that the 3' incision can occur without the 5' incision, leading us to conclude that under certain conditions the two incisions can occur independently.
Resonant scattering induced thermopower in one-dimensional disordered systems
Creators: name: Müller, D.
name: Smit, W. J.
name: Sigrist, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: This study analyzes thermoelectric properties of a one-dimensional random conductor which shows localization effects and simultaneously includes resonant scatterers yielding sharp conductance resonances. These sharp features give rise to a distinct behavior of the Seebeck coefficient in finite systems and incorporate the degree of localization as a means to enhance thermoelectric performance, in principle. The model for non-interacting electrons is discussed within the Landauer-Büttiker formalism such that analytical treatment is possible for a wide range of properties, if a special averaging scheme is applied. The approximations in the averaging procedure are tested with numerical evaluations showing good qualitative agreement, with some limited quantitative disagreement. The validity of low-temperature Mott's formula is determined and a good approximation is developed for the intermediate temperature range. In both regimes the intricate interplay between Anderson localization due to disorder and conductance resonances of the disorder potential is analyzed.
description: 14 pages, 11 figures
ESM Table 2 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships.
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: The results of the linear regression models in Fig. 7b. The p-values of coefficients of a (β1) of k=1, 2 were significant (at the 5% level).
(2041) Emily Beardshaw
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Multi-Agent Control of Fuid Systems – Comparison of Approaches
Creators: name: Logan, Kevin
name: Stürmer, Marius
name: Müller, Tim
name: Meck, Tobias
name: Pelz, Peter F.
Publisher: name: UNSPECIFIED
Year: 2023

description: Multi-agent systems allow system-wide, energy efficient control of fluid systems, fulfilling volume flow demands even in the face of disruptions within the communication network.
Integrin-mediated Tyrosine Phosphorylation and Cytokine Message Induction in Monocytic Cells: A POSSIBLE SIGNALING ROLE FOR THE Syk TYROSINE KINASE
Creators: name: Bolen, J. B.
name: Mondal, K.
name: Juliano, R. L.
name: Haskill, S.
name: Lin, T. H.
name: Rosales, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins. In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa. In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta. The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events. The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk. In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin. In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected. These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.
Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor)
Creators: name: Meissner, G.
name: Grunwald, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The membrane topology of the skeletal muscle ryanodine receptor (RyR1) was investigated using site-directed antibodies directed against amino acid sequences 2804-2930, 4581-4640, 4860-4886, and 4941-5037. Ab(2804-2930) bound with identical affinity to either closed or permeabilized sarcoplasmic reticulum vesicles, confirming the cytoplasmic location of this segment. Ab(4581-4640) did not bind to closed vesicles but bound well to permeabilized vesicles, supporting a lumenal location for this segment. Ab(4860-4886) did not bind to closed vesicles but exhibited weak binding to the permeabilized vesicles, suggesting that a portion of the epitope may be exposed on the lumenal surface. The C-terminal antibody (Ab(4941-5037)) bound weakly to closed vesicles, and binding was not significantly enhanced by permeabilizing vesicles with low concentrations of non-denaturing detergent. However, the C-terminal antibodies bound efficiently to vesicles which were transiently incubated at alkaline pH or subjected to trypsinolysis, conditions where few of the vesicles were permeabilized. These results support a model for the membrane topology of the ryanodine receptor as proposed by Takeshima et al. (Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., and Numa, S. (1989) Nature 339, 439-445). The results also suggest that the native conformation of the C terminus is inaccessible to antibodies.
Text mining to identify skills, stakeholders and capabilities: the case of Artificial Intelligence in Emilia-Romagna
Creators: name: Quinquillá, Arnau
name: Duran-Silva, Nicolau
name: Massucci, Francesco Alessandro
name: Fuster, Enric
name: Rondelli, Bernardo
name: Bologni, Leda
name: Mazzoni, Lucia
name: Moretti, Giorgio
Publisher: name: Zenodo
Year: 2020
Subjects: Artificial Intelligence
Research to Business
R2B
Sustainable development goals
Text mining

description: This is a poster presented at the 6th World Open Innovation Conference Objectives The study presents a semantic analysis to map the science, technology and innovation (STI) activities in the field of Artificial Intelligence in the Emilia-Romagna region (Italy). The study aims at fostering research-to-business collaborations; detecting existing and potential capabilities to address challenge-driven innovations. We identified which topics are covered, what is the relative regional specialisation, which are the key actors, and which are the internal and external linkages. Finally, we measured how the topics have been evolving in time and how the specific domain of Artificial intelligence is applied to solve societal challenges (SDGs). Methodology We analysed single STI records proceeding from different repositories. Text mining techniques were applied to the publication abstracts, patent descriptions and R&I project objectives to extract a wealth of textual information describing in detail STI activities and results. The methodology uses both automated text-mining computer techniques and qualitative and quantitative analysis.The approach is divided into the following steps: Extraction of documents produced by the regional research ecosystem; Definition of a vocabulary of key concepts that define the domain of research in Artificial intelligence Use of the vocabulary to identify, among the texts extracted in step 1, all those related to the domain of interest Fine-grained, unambiguous identification of the actors Quantitative analyses using the extracted data
ESM Section 2 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships.
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: Development of Eq. 1
Aspects of Quadratic Gravity
Creators: name: Alvarez-Gaume, Luis
name: Kehagias, Alex
name: Kounnas, Costas
name: Lust, Dieter
name: Riotto, Antonio
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss quadratic gravity where terms quadratic in the curvature tensor are included in the action. After reviewing the corresponding field equations, we analyze in detail the physical propagating modes in some specific backgrounds. First we confirm that the pure $R^2$ theory is indeed ghost free. Then we point out that for flat backgrounds the pure $R^2$ theory propagates only a scalar massless mode and no spin-two tensor mode. However, the latter emerges either by expanding the theory around curved backgrounds like de Sitter or anti-de Sitter, or by changing the long-distance dynamics by introducing the standard Einstein term. In both cases, the theory is modified in the infrared and a propagating graviton is recovered. Hence we recognize a subtle interplay between the UV and IR properties of higher order gravity. We also calculate the corresponding Newton's law for general quadratic curvature theories. Finally, we discuss how quadratic actions may be obtained from a fundamental theory like string- or M-theory. We demonstrate that string theory on non-compact $CY_3$ manifolds, like a line bundle over $\mathbb{CP}^2$, may indeed lead to gravity dynamics determined by a higher curvature action.
description: 24 pages, 2 figures, revised version contains additional references plus corrected typos
Learning Trivializing Gradient Flows for Lattice Gauge Theories
Creators: name: Bacchio, Simone
name: Kessel, Pan
name: Schaefer, Stefan
name: Vaitl, Lorenz
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: flow: gradient
machine learning
lattice field theory
lattice
SU(3)
scaling
performance

description: We propose a unifying approach that starts from the perturbative construction of trivializing maps by Lüscher and then improves on it by learning. The resulting continuous normalizing flow model can be implemented using common tools of lattice field theory and requires several orders of magnitude fewer parameters than any existing machine learning approach. Specifically, our model can achieve competitive performance with as few as 14 parameters while existing deep-learning models have around 1 million parameters for $SU(3)$ Yang--Mills theory on a $16^2$ lattice. This has obvious consequences for training speed and interpretability. It also provides a plausible path for scaling machine-learning approaches toward realistic theories.
Efficient spin current source using a half-Heusler alloy topological semimetal with Back-End-of-Line compatibility
Creators: name: Shirokura, Takanori
name: Fan, Tuo
name: Khang, Nguyen Huynh Duy
name: Kondo, Tsuyoshi
name: Hai, Pham Nam
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Topological materials, such as topological insulators (TIs), have great potential for ultralow power spintronic devices, thanks to their giant spin Hall effect. However, the giant spin Hall angle ($θ_{SH}$ > 1) is limited to a few chalcogenide TIs with toxic elements and low melting points, making them challenging for device integration during the silicon Back-End-of-Line (BEOL) process. Here, we show that by using a half-Heusler alloy topological semi-metal (HHA-TSM), YPtBi, it is possible to achieve both a giant $θ_{SH}$ up to 1.6 and a high thermal budget up to 600$°$C. We demonstrate magnetization switching of a CoPt thin film using the giant spin Hall effect of YPtBi by current densities lower than those of heavy metals by one order of magnitude. Since HHA-TSM includes a group of three-element topological materials with great flexibility, our work opens the door to the third-generation spin Hall materials with both high $θ_{SH}$ and high compatibility with the BEOL process that would be easily adopted by the industry.
The spectral reconstruction of inclusive rates
Creators: name: Bulava, John
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2023
Subjects: density: spectral
two-point function: electromagnetic
current: electromagnetic
sigma model: O(3)
dimension: 2
final state: hadronic
correlation function
lattice field theory
scattering
conservation law

description: A recently re-discovered variant of the Backus-Gilbert algorithm for spectral reconstruction enables the controlled determination of smeared spectral densities from lattice field theory correlation functions. A particular advantage of this approach is the \emph{a priori} specification of the kernel with which the underlying spectral density is smeared, allowing for variation of its peak position, smearing width, and functional form. If the unsmeared spectral density is sufficiently smooth in the neighborhood of a particular energy, it can be obtained from an extrapolation to zero smearing-kernel width at fixed peak position. A natural application for this approach is scattering processes summed over all hadronic final states. As a proof-of-principle test, an inclusive rate is computed in the two-dimensional O(3) sigma model from a two-point correlation function of conserved currents. The results at finite and zero smearing radius are in good agreement with the known analytic form up to energies at which 40-particle states contribute, and are sensitive to the 4-particle contribution to the inclusive rate. The straight-forward adaptation to compute the $R$-ratio in lattice QCD from two-point functions of the electromagnetic current is briefly discussed.
Additional file 1 of Phenotypic differences between female and male individuals with suspicion of autism spectrum disorder
Creators: name: Stroth, Sanna
name: Tauscher, Johannes
name: Wolff, Nicole
name: Küpper, Charlotte
name: Poustka, Luise
name: Roepke, Stefan
name: Roessner, Veit
name: Heider, Dominik
name: Kamp-Becker, Inge
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Table S1. Psychopathological characterization of children and young adolescents: All ICD-10 diagnoses are listed, including comorbidities, separated for sex. Table S2. Psychopathological characterization of Older Adolescents/Adults—all ICD-10 diagnoses are listed, including comorbidities, separated for sex. Table S3. Pearson correlations between optimal feature set, age and IQ.
ESM Table 2 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: The results of the linear regression models in Fig. 7b. The p-values of coefficients of a (β1) of k=1, 2 were significant (at the 5% level).
(2038) Elizabeth [Beardshaw]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(2039) Charlotte Beardshaw
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(2040) Eliza Beardshaw
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
СПОСОБЫ УТИЛИЗАЦИИ ТВЕРДЫХ БЫТОВЫХ ОТХОДОВ
Creators: name: Махмудов, Рустам
Publisher: name: Zenodo
Year: 2024

description: В статье изучены современные способы переработки мусора такие как компостирование, рециклинг, брикетирование. А также изучен способ преобразования мусора в энергию.
Additional file 1 of Manual therapy interventions in the management of adults with prior cervical spine surgery for degenerative conditions: a scoping review
Creators: name: Gliedt, Jordan A.
name: Dawson, Aprill Z.
name: Daniels, Clinton J.
name: Spector, Antoinette L.
name: Cupler, Zachary A.
name: King, Jeff
name: Egede, Leonard E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 1: Definition and examples of manual therapy interventions.
Major Histocompatibility Complex Class II-associated Invariant Chain Gene Expression Is Up-regulated by Cooperative Interactions of Sp1 and NF-Y
Creators: name: Ting, J. P.Y.
name: Brown, A. M.
name: Wright, K. L.
name: Vilen, B. J.
name: Moore, T. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Expression of the major histocompatibility complex (MHC) class II-associated invariant chain (Ii) is required for efficient and complete presentation of antigens by MHC class II molecules and a normal immune response. The Ii gene is generally co-regulated with the MHC class II molecules at the level of transcription and a shared SXY promoter element has been described. This report defines the proximal promoter region of Ii which may regulate Ii transcription distinct from MHC class II. In vivo genomic footprinting identified an occupied, imperfect CCAAT box and an adjacent GC box in the proximal region. These sites are bound in Ii-ositive cell lines and upon interferon-gamma induction of Ii transcription. In contrast, both sites are unoccupied in Ii-egative cell lines and in inducible cell lines prior to interferon-gamma treatment. Together these two sites synergize to stimulate transcription. Independently, the transcription factor NF-Y binds poorly to the imperfect CCAAT box with a rapid off rate, while Sp1 binds to the GC box. Stabilization of NF-Y binding occurs upon Sp1 binding to DNA. In addition, the half-life of Sp1 binding also increased in the presence of NF-Y binding. These findings suggest a mechanism for the complete functional synergy of the GC and CCAAT elements observed in Ii transcription. Furthermore, this report defines a CCAAT box of imperfect sequence which binds NF-Y and activates transcription only when stabilized by an adjacent factor, Sp1.
Additional file 2 of Manual therapy interventions in the management of adults with prior cervical spine surgery for degenerative conditions: a scoping review
Creators: name: Gliedt, Jordan A.
name: Dawson, Aprill Z.
name: Daniels, Clinton J.
name: Spector, Antoinette L.
name: Cupler, Zachary A.
name: King, Jeff
name: Egede, Leonard E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 2: Excluded citations.
ESM Section 3 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships.
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: Source Code of Individual-based Simulations
Mammalian DNA (Cytosine-5-)-methyltransferase Expressed in Escherichia coli , Purified and Characterized
Creators: name: Hutchison III, C. A.
name: Tollefsbol, T. O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Besides modulating specific DNA-protein interactions, methylated cytosine, frequently referred to as the fifth base of the genome, also influences DNA structure, recombination, transposition, repair, transcription, imprinting, and mutagenesis. DNA (cytosine-5-)-methyltransferase catalyzes cytosine methylation in eukaryotes. We have cloned and expressed this enzyme in Escherichia coli, purified it to apparent homogeneity, characterized its properties, and we have shown that it hemimethylates DNA. The cDNA for murine maintenance methyltransferase was reconstructed and cloned for direct expression in native form. Immunoblotting revealed a unique protein (M(r) = 190,000) not present in control cells. The mostly soluble overexpressed protein was purified by DEAE, Sephadex, and DNA cellulose chromatography. Peak methylating activity correlated with methyltransferase immunoblots. The purified enzyme preferentially transferred radioactive methyl moieties to hemimethylated DNA in assays and on autoradiograms. All of the examined properties of the purified recombinant DNA methyltransferase are consistent with the enzyme purified from mammalian cells. Further characterization revealed enhanced in vitro methylation of premethylated oligodeoxynucleotides. The cloning of hemimethyltransferase in E. coli should allow facilitated structure-function mutational analysis of this enzyme, studies of its biological effects in prokaryotes, and potential large scale methyltransferase production for crystallography, and it may have broad applications in maintaining the native methylated state of cloned DNA.
(2036) William Wood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene
Creators: name: Osada, J.
name: Maeda, N.
name: Wong, H.
name: De Silva, H. V.
name: Zhang, S. H.
name: Homanics, G. E.
name: Borensztajn, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: In order to gain better understanding of the function of hepatic lipase (HL) in vivo, we have generated mice that lack HL using gene targeting in embryonic stem cells. No mRNA for HL was detected in the liver of homozygous mutants, and no HL activity was detected in their plasma. Total cholesterol levels in plasma of mutant mice were increased by about 30% compared with wild type animals. Plasma phospholipids and high density lipoprotein (HDL) cholesterol were also increased, but plasma levels of triglycerides were not altered. Analysis of density fractions of plasma lipoproteins revealed that HDL1 (d = 1.02-1.04) was increased in homozygous mutants fed regular chow. In response to a diet containing high fat and high cholesterol, HDL cholesterol was doubled in the mutants, but was slightly decreased in the wild type mice. These results clearly demonstrate the importance of HL in HDL remodeling and metabolism in vivo. Various earlier studies suggested a role of HL in metabolism of triglyceride-rich particles, but the mutant mice appear to have no impairment in clearing them; the mutants clear exogenously introduced chylomicrons from plasma at a normal rate, and they tolerate acute fat loading as well as normal animals unless the loading is extreme. These differences may reflect species differences. However, it is also possible that the consequence of absence of HL as in our mutants is different from the consequence when nonfunctional HL protein is present as in the human HL-deficient patients and in rats treated with HL antibodies. We hypothesize that absence of HL in mutant mice allows other lipases to bind to the sites in the liver normally occupied by HL and facilitate the clearance of triglyceride-rich particles in these mice.
ESM Table 2 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: The results of the linear regression models in Fig. 11b. All p-values of coefficients of a (β1) were significant (at the 5% level).
p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat
Creators: name: Baldwin Jr., A. S.
name: Gualberto, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Tumor necrosis factor alpha (TNF) is a potent activator of transcription directed by the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). We have recently reported that the p53 tumor suppressor gene product binds to a site within the Sp1 binding region of the HIV-1 LTR and contributes to the TNF induction of this promoter. In this study we show that the transcription factor Sp1 cooperates with p53 in the transcriptional activation directed by the HIV-1 LTR. The presence of Sp1 increased p53 binding to its recognition sequence in the HIV-1 LTR, and experiments in Drosophila cells show that Sp1 is necessary for full transactivation by mutant p53. Importantly, TNF induced the association between p53 and Sp1 in Jurkat T cells. These data demonstrate a synergistic role for these proteins in the mechanism of TNF induction of HIV-1 LTR-mediated transcription and suggest that Sp1 may play an important role in modulating certain functions of p53.
ESM Section 2 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: Development of Eq. 1
ESM Section 3 from Two types of social grooming methods depending on the trade-off between the number and strength of social relationships
Creators: name: Takano, Masanori
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: Source Code of Individual-based Simulations
title: Urban Data Platforms and Urban Critical Infrastructure
Creators: name: Leštáková, Michaela
name: Hessel, Frank
name: Logan, Kevin
name: Alhamwy, Yasin
name: Morgen, Andreas
name: Pietsch, Martin
Publisher: name: UNSPECIFIED
Year: 2023

description: Urban data platforms (UDP) are currently being launched in many cities as a part of their smart city strategies. They gather and provide access to data from various urban domains, including critical infrastructure. We performed a survey about UDPs in Germany. Focusing on their potential for improving resilience of the city (resilience through ICT) and the resilience of the UDPs themselves (resilience for ICT), our key findings were: ▪ UDP providers tend to focus on normal conditions rather than crisis ▪ critical infrastructure is often not covered ▪ lack of focus on crisis shows in the design of the UDPs as well
Purification and Characterization of the XPF-ERCC1 Complex of Human DNA Repair Excision Nuclease
Creators: name: Bessho, T.
name: Matsunaga, T.
name: Sancar, A.
name: Park, C. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: A complex, which consists of ERCC1 (38 kDa) and a 112-kDa protein, was purified from HeLa cells to homogeneity. This complex complemented the nucleotide excision repair defects of rodent ERCC-1, ERCC-4, and human XP-F mutant cell-free extracts, indicating that the 112-kDa protein is XPF/ERCC4 and providing direct biochemical evidence that XPF and ERCC4 are identical. The XPF/ERCC4-ERCC1 complex has an endonuclease activity with preference for single-stranded DNA and a single-stranded region of duplex DNA with a "bubble" structure. This complex also nicks supercoiled DNA weakly, and this nicking activity is stimulated by human replication protein A when the DNA contains UV damage.
Gravitational lensing by a Bronnikov-Kim wormhole under a weak-field approximation and in a strong deflection limit
Creators: name: Tsukamoto, Naoki
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider gravitational lensing under a weak-field approximation and in a strong deflection limit by a Bronnikov-Kim wormhole with the same metric as the one of a wormhole which has been suggested in Einstein-Dirac-Maxwell theory. The metric approaches into the metric of an extreme charged Reissner-Nordström black hole in a black hole limit and it becomes the metric of an spatial Schwarzschild wormhole in an ultrastatic limit. In both of the black hole limit and the ultrastatic limit, the coefficient of a divergent term and the constant term of the deflection angle of a light in the strong deflection limit can be obtained exactly without expanding of parameters of the spacetime. Interestingly, in the both limits to the black hole and the ultrastatic wormhole, we obtain exactly the same coefficient and constant term in the strong deflection limit.
description: 11 pages, 5 figures, minor correction, accepted for publication in Physical Review D
Reconstitution of Human DNA Repair Excision Nuclease in a Highly Defined System
Creators: name: Park, C. H.
name: Sancar, A.
name: Mu, D.
name: Matsunaga, T.
name: Hsu, D. S.
name: Reardon, J. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Xeroderma pigmentosum is a hereditary disease caused by defective DNA repair. Somatic cell genetics and biochemical studies with cell-free extracts indicate that at least 16 polypeptides are required to carry out the repair reaction proper, i.e. the removal of the lesion from the DNA by the dual incisions of the damaged strand. To find out if these proteins are necessary and sufficient for excision repair, they were obtained at a high level of purity in five fractions. The mixture of these five fractions reconstituted the excision nuclease (excinuclease) activity. Using the reconstituted excinuclease, we found that the excised fragment remains associated with the post-incision DNA-protein complex, suggesting that accessory proteins are needed to release the excised oligomer.
(2037) Charles B Beardshaw
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MPEC 2024-R228 : 2012 FO35
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Supplementary Information from It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods.
Creators: name: Qureshi, Bilal M.
name: Behrmann, Elmar
name: Schöneberg, Johannes
name: Loerke, Justus
name: Bürger, Jörg
name: Mielke, Thorsten
name: Giesebrecht, Jan
name: Noé, Frank
name: Lamb, Trevor D.
name: Hofmann, Klaus Peter
name: Spahn, Christian M. T.
name: Heck, Martin
Publisher: name: The Royal Society
Year: 2018
Subjects: Biophysics
Biochemistry
Structural Biology

description: Numerical fitting procedure of PDE6 activation, Electron microscopy, image processing and rigid body docking, and Particle-based reaction-diffusion simulations
Interacting bosons in two-dimensional flat band systems
Creators: name: Pudleiner, Petra
name: Mielke, Andreas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The Hubbard model of bosons on two dimensional lattices with a lowest flat band is discussed. In these systems there is a critical density, where the ground state is known exactly and can be represented as a charge density wave. Above this critical filling, depending on the lattice structure and the interaction strength, the additional particles are either delocalised and condensate in the ground state, or they form pairs. Pairs occur at strong interactions, e.g., on the chequerboard lattice. The general mechanism behind this phenomenon is discussed.
description: small changes, one figure added. Accepted for publication in EPJB
(2033) Ann N Wood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Regulation of Vascular Smooth Muscle Growth by -Adrenoreceptor Subtypes in Vitro and in Situ
Creators: name: Yang, Nengyu
name: Chen, Li Qian
name: Xin, Xiaohua
name: Eckhart, Andrea D.
name: Faber, James E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Rat aorta smooth muscle cells which express all three alpha 1-adrenoreceptors (alpha 1A, alpha 1B and alpha 1D) were used to determine the effect of stimulation of alpha 1-adrenergic receptor subtypes on cell growth. "Combined" alpha 1-adrenoreceptor subtype stimulation with norepinephrine alone caused a concentration-dependent, prazosin-sensitive increase in protein content and synthesis: 48 h of stimulation at 1 microM increased cell protein to 216 +/- 40% of time-matched controls (p = 0.008) and RNA to 140 +/- 13% (p = 0.03); protein synthesis increased to 167 +/- 13% (p < 0.01) after 24 h. Stimulation with norepinephrine plus the selective alpha 1A/alpha 1D antagonist 5-methylurapidil produced greater increases in alpha-actin mRNA (270 +/- 40% at 8 h; p = 0.007), total cell protein (220 +/- 45% at 24 h; p = 0.004), and RNA (135 +/- 8% at 24 h; p = 0.01). These effects were prevented by pretreatment with the selective alpha 1B antagonist chloroethylclonidine. Comparable results were obtained for intact aortae. Stimulation with norepinephrine plus 5-methylurapidil increased (p < 0.05) tissue protein, RNA, dry weight, and alpha-actin mRNA; and as in culture cells, combined stimulation with norepinephrine alone attenuated these responses. By comparison, adventitia (fibroblasts) was unaffected. Removal of endothelial cells had no effect. alpha 1B mRNA decreased by 42 +/- 12% (p = 0.01) in cultured cells during combined alpha 1-adrenoreceptor stimulation and by 23 +/- 8% (p = 0.03) for intact aorta. alpha 1D and beta-actin mRNA were unchanged in cultured cells, aorta media, and adventitia. These findings suggest that prolonged stimulation of chloroethylclonidine-sensitive, possibly alpha 1B-adrenoceptors induces hypertrophy of arterial smooth muscle cells and that stimulation of 5-methylurapidil-sensitive, non-alpha 1B-adrenoreceptors attenuates this growth response.
(2035) Mileah/Millah Wood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Simulation input conditions from Comment on ‘The cutting of metals by plastic buckling’ by Udupa et al..
Creators: name: T. H. C. Childs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Mechanics
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Text and a listing of all geometry, material, process and meshing input data for the simulations
Supplementary Information from It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
Creators: name: Qureshi, Bilal M.
name: Behrmann, Elmar
name: Schöneberg, Johannes
name: Loerke, Justus
name: Bürger, Jörg
name: Mielke, Thorsten
name: Giesebrecht, Jan
name: Noé, Frank
name: Lamb, Trevor D.
name: Hofmann, Klaus Peter
name: Spahn, Christian M. T.
name: Heck, Martin
Publisher: name: The Royal Society
Year: 2018
Subjects: Biophysics
Biochemistry
Structural Biology

description: Numerical fitting procedure of PDE6 activation, Electron microscopy, image processing and rigid body docking, and Particle-based reaction-diffusion simulations
Magnetic reversal modes in multisegmented nanowire arrays with long aspect ratio
Creators: name: Rando, E. A.
name: Allende, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A detailed numerical analysis of the magnetization reversal processes in multisegmented nanowire arrays was developed. The nanowires have a long aspect ratio and are formed by magnetic and non-magnetic sections alternately arranged in such a way that the array resembles magnetic layers separated by non-magnetic layers. Attention has been focused on the influence of magnetostatic interaction in the magnetic pattern formation of these magnetic nanostructures. Results from a magnetic correlation function among layers show that three different reversal modes can be detected depending on the number and distance between the magnetic segments. As a consequence of the different reversal modes, a non-monotonic behavior of the annihilation field in function of the distance between the layers is evidenced. Thus, these results are important for the production of magnetic devices with multisegmented nanowire arrays.
Structure and Function of the UvrB Protein
Creators: name: Kim, S. T.
name: Hsu, D. S.
name: Sancar, A.
name: Sun, Q.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: UvrB plays a central role in (A)BC excinuclease. To identify the regions of UvrB which are involved in interacting with UvrA, UvrC, and DNA, deletion mutants, point mutants, and various fusion forms of UvrB were constructed and characterized. We found that the region encompassing amino acid residues 115-250 of UvrB binds to UvrA, while the region encompassing amino acid residues 547-673 binds to both UvrA and UvrC. In addition, the region between these two domains, which contains the helicase motifs II-VI, was found to be involved in binding to DNA. Within this DNA-binding region, two point mutants, E265A and E338A, were found to be unable to bind DNA while two residues, Phe-365 and Phe-496, were identified to interact with DNA. Furthermore, fluorescence quenching studies with mutants F365W and F496W and repair of thymine cyclobutane dimers by photoinduced electron transfer by these mutants suggest that residues Phe-365 and Phe-496 interact with DNA most likely through stacking interactions.
Additional file 1 of Plasma Neuron-Specific Enolase is not a reliable biomarker for staging Trypanosoma brucei rhodesiense sleeping sickness patients
Creators: name: Kato, Charles D.
name: Twesigye, Dorothy
name: Alibu, Vincent P.
name: Nanteza, Ann
name: Nsubuga, Julius
name: Mugasa, Claire M.
name: Matovu, Enock
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 1: Figure S1. Power calculation for early and late-stage patients.
(2031) John Lawrence Wood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.