cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Maxwell-Gleichungen, Lagrange-Dichte und Dissipationsfunktion in der Kontinuumstheorie bewegter Versetzungen
Creators: name: Baumgarte, Joachim
Publisher: name: Vieweg
Year: 1972
Subjects: subject: Brunsvicensien der Universitätsbibliothek Braunschweig
subject: Abhandlungen der BWG
subject: 530

description: Die Feldgleichungen der linearen Versetzungstheorie lassen sich in eine Analogie zu den Maxwellsehen Gleichungen des elektromagnetischen Feldes setzen. Das Postulat der "Lokalisierbarkeit der Energie in Raum und Zeit" wird durch das Variationsproblem der stationären Wirkung mit Lagrange-Dichte und Dissipationsfunktion erfüllt. Das Variationsproblem liefert auch die konstitutiven Gleichungen in einer weitgehend allgemeinen Darstellung. Einfache Annahmen über die Materialgleichungen ermöglichen die Beschreibung der physikalischen Vorgänge in einem Kontinuum, daß außer elastischen Eigenschaften auch
viskoses und insbesondere plastisches Verhalten - wobei dies den wandernden Versetzungen zuzuschreiben ist - zeigt.
Colpodium hedbergii Tzvelev
Creators: name: Zhou, Ya-Dong
name: Mwachala, Geoffrey
name: Hu, Guang-Wan
name: Wang, Qing-Feng
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Colpodium
Colpodium hedbergii

description: Colpodium hedbergii (Melderis) Tzvelev  —
Habit: Herb.
Habitat:AZ; 2 500–4 200 m. Distribution: IIIb.
 Voucher: Kazit Valley West, Alt. 4 115 m, 24 May 1966, Hanid 157 (EA).
References: Clayton (1970), Young & Peacock (1985), Abdi (2013), Agnew (2013).
description: Published as part of Zhou, Ya-Dong, Mwachala, Geoffrey, Hu, Guang-Wan & Wang, Qing-Feng, 2022, Annotated checklist of the vascular plants of Mount Kenya, East Africa, pp. 1-108 in Phytotaxa 546 (1) on page 36, DOI: 10.11646/phytotaxa.546.1.1, http://zenodo.org/record/6550464
Assessing groundwater discharge to streams with distributed temperature sensing technology
Creators: name: Birkham, T.
name: Barbour, S. Lee
name: Goodbrand, A.
name: Tallon, L. K.
name: Szmigielski, J.
name: Klein, R.
Publisher: name: The University of British Columbia
Year: 2014

description: Characterization of the interactions of groundwater with surface stream water is fundamental to understanding and managing stream water quality in natural and altered watersheds. The spatial and temporal variability in the exchange of water and solutes across the streambed affects stream water quality evolution along the channel length, especially in coarse-grained alluvial sediments. Identifying and delineating areas of groundwater discharge has the potential to inform water quality management strategies including the location and design of intake structures, groundwater cut-off systems, or permeable reactive barriers. Distributed temperature sensing (DTS) is an emerging technology that has found wide application in stream hydrology. A DTS system integrates a fibre-optic (FO) cable to measure continuous temperature profiles (manufacture reported accuracy of ±1 °C and resolution of ±0.01 °C) with spatial resolutions of 1 m or better over distances of up to several kilometres. In September 2013, a DTS cable was installed in a predominantly coarse-textured stream channel at a coal mining operation in the Elk Valley of British Columbia. The objective was to evaluate the utility of a FO DTS system in a location where identification of groundwater discharges to a stream was being studied as part of Teck Resources Limited (Teck) applied research and development program focused on managing water quality in mine watersheds. This study was intended as a verification of methods for in-stream DTS installation and measurements with recommendations made for improved calibration procedures. Temperature was measured along a 160-m stretch of stream and streambed at 20 minute sampling intervals using a 5 minute signal integration time over six days. In-stream DTS measurements were successful in delineating a localized area of lower temperature identified as a groundwater discharge zone. The measurement of cooler groundwater discharge in the streambed relative to the stream was corroborated by the presence of well-established riparian vegetation and a streambank seep.
title: Digital Orihon (デジタル折り本): The (un)continuous shape of the novel
Creators: name: Wright, David Thomas Henry
Publisher: name: Electronic Book Review
Year: 2021

description: Wright explores the digital manifestation of an orihon manuscript style for how it can expand how we think of the novel's form. He considers how digital versions of J.M. Coetzee's Diary of a Bad Year and his own print novella make use of the concept of the fold as identified in the orihon style.
title: Generalisierte Kontinua mit Mikro-Struktur in 3n Dimensionen
Creators: name: Baumgarte, Joachim
Publisher: name: Vieweg
Year: 1972
Subjects: subject: Brunsvicensien der Universitätsbibliothek Braunschweig
subject: Abhandlungen der BWG
subject: 530

description: Von der Atomgittertheorie ausgehend, wird durch "Kontinuisierung" ein generalisiertes Gesamtkontinuum erhalten, das aus n ineinanderliegenden durch Kräfte gekoppelten Unterkontinua besteht. In den Bewegungsgleichungen für das 3n-dimensionale Verschiebungsfeld treten neben n2 Spannungstensoren, bei denen die endliche Reichweite der atomaren Wechselwirkungskräfte (Nichtlokalität) berücksichtigt wird, auch die Verschiebungsvektoren selbst auf. Es werden die Symmetriebeziehungen für die Tensorindizes untersucht. Das Cosserat-Kontinuum wird als ein Sonderfall dieser Theorie abgeleitet. Das Wellenspektrum zeigt 3 akustische und 3(n-1) optische Zweige und ermöglicht die Berechnung der spezifischen Wärme als Funktion der absoluten Temperatur analog einer verallgemeinerten Debye-Theorie.
Rotating ground states of trapped Bose atoms with arbitrary two-body interactions
Creators: name: Vorov, O. K.
name: Hussein, M. S.
name: Van Isacker, P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: In a k-dimensional system of weakly interacting Bose atoms trapped by a spherically symmetric and harmonic external potential, an exact expression is obtained for the rotating ground states at a fixed angular momentum. The result is valid for arbitrary interactions obeying minimal physical requirements. Depending on the sign of a modified scattering length, it reduces to either a collective rotation or a condensed vortex state, with no alternative. The ground state can undergo a kind of quantum phase transition when the shape of the interaction potential is smoothly varied.
description: Talk given at the International Conference on Theoretical Physics (TH2002),Paris, UNESCO, 22-27 July; 11 pages, 3 figures, few typos fixed
Variational analysis for a generalized spiked harmonic oscillator
Creators: name: Hall, Richard L.
name: Saad, Nasser
Publisher: name: arXiv
Year: 1999
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A variational analysis is presented for the generalized spiked harmonic oscillator Hamiltonian operator H, where H = -(d/dx)^2 + Bx^2+ A/x^2 + lambda/x^alpha, and alpha and lambda are real positive parameters. The formalism makes use of a basis provided by exact solutions of Schroedinger's equation for the Gol'dman and Krivchenkov Hamiltonian (alpha = 2), and the corresponding matrix elements that were previously found. For all the discrete eigenvalues the method provides bounds which improve as the dimension of the basis set is increased. Extension to the N-dimensional case in arbitrary angular-momentum subspaces is also presented. By minimizing over the free parameter A, we are able to reduce substantially the number of basis functions needed for a given accuracy.
description: 15 pages, 1 figure
Strong-field nonlinear optical properties of monolayer black phosphorus
Creators: name: Chen, Zi-Yu
name: Qin, Rui
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Within the past few years, atomically thin black phosphorus (BP) has been demonstrated as a fascinating new 2D material that is promising for novel nanoelectronics and nanophotonics applications, due to its many unique properties such as direct and widely tunable bandgap, high carrier mobility and remarkable intrinsic in-plane anisotropy. However, its important extreme nonlinear behavior and ultrafast dynamics of carriers under strong-field excitation have yet to be revealed to date. Herein, we report nonperturbative high harmonic generation (HHG) in monolayer BP by first-principles simulations. We show that BP exhibits extraordinary HHG properties, with clear advantages over three major types of 2D materials under intensive study, i.e., semimetallic graphene, semiconducting MoS$_2$, and insulating hexagonal boron nitride, in terms of HHG cutoff energy and spectral intensity. This study advances the scope of current research activities of BP into a new regime, suggesting its promising future in applications of extreme-ultraviolet and attosecond nanophotonics, and also opening doors to investigate the strong-field and ultrafast carrier dynamics of this emerging material.
description: 24 pages, 5 figures
Homothetic perfect fluid space-times
Creators: name: Carot, J.
name: Sintes, A. M.
Publisher: name: arXiv
Year: 1996
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A brief summary of results on homotheties in General Relativity is given, including general information about space-times admitting an r-parameter group of homothetic transformations for r>2, as well as some specific results on perfect fluids. Attention is then focussed on inhomogeneous models, in particular on those with a homothetic group $H_4$ (acting multiply transitively) and $H_3$. A classification of all possible Lie algebra structures along with (local) coordinate expressions for the metric and homothetic vectors is then provided (irrespectively of the matter content), and some new perfect fluid solutions are given and briefly discussed.
description: 27 pages, Latex file, Submitted to Class. Quantum Grav
Holomorphic anomaly of 2d Yang-Mills theory on a torus revisited
Creators: name: Okuyama, Kazumi
name: Sakai, Kazuhiro
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the large $N$ 't Hooft expansion of the chiral partition function of 2d $U(N)$ Yang-Mills theory on a torus. There is a long-standing puzzle that no explicit holomorphic anomaly equation is known for the partition function, although it admits a topological string interpretation. Based on the chiral boson interpretation we clarify how holomorphic anomaly arises and propose a natural anti-holomorphic deformation of the partition function. Our deformed partition function obeys a fairly traditional holomorphic anomaly equation. Moreover, we find a closed analytic expression for the deformed partition function. We also study the behavior of the deformed partition function both in the strong coupling/large area limit and in the weak coupling/small area limit. In particular, we observe that drastic simplification occurs in the weak coupling/small area limit, giving another nontrivial support for our anti-holomorphic deformation.
description: 30 pages, 7 figures, v2: typos corrected, published version
Probing Diseases using Small Molecules
Creators: Liu, Hengrui
Publisher: name: Columbia University
Year: 2021
Subjects: Chemistry
COVID-19 (Disease)--Treatment
Cancer--Treatment
Therapeutics

description: Small molecules are powerful tools to probe biological systems and cure diseases. In the scope of this dissertation, small molecules were applied to study three distinct disease models: cancer, Sedaghatian-type spondylometaphyseal dysplasia (SSMD), and COVID-19. First, encouraged by the recently reported vulnerability of drug-resistant, metastatic cancers to GPX4 (Glutathione Peroxidase 4) inhibition, we examined the basis for nanomolar potency of proof-of-concept GPX4 inhibitors, which revealed an unexpected allosteric binding site. Through hierarchical screening of a lead-optimized compound library, we identified novel small molecules binding to this allosteric site. Second, a homozygous point mutation in the GPX4 gene was identified in three living patients with SSMD. With a structure-based analysis and cell models of the patient-derived variant, we found that the missense variant significantly changed the protein structure and caused substantial loss of enzymatic function. Proposed proof-of-concept treatments were subsequentially validated in patient fibroblasts. Our further structural investigation into the origin of the reduced enzymatic activity revealed a key residue modulating GPX4 enzymatic function. We also found that the variant alters the degradation of GPX4, unveiling the native degradation mechanism of GPX4 protein. Third, driven by the recent urgent need for COVID-19 antiviral therapeutics, we utilized the conservation of 3CL protease substrate-binding pockets across coronaviruses to identify four structurally divergent lead compounds that inhibit SARS-CoV-2 3CL protease. With structure-based optimization, we ultimately identified drug-like compounds with < 10 nM potency for inhibiting the SARS-CoV-2 3CL protease and blocking SARS-CoV-2 replication in human cells.
Cymbopogon caesius Stapf
Creators: name: Zhou, Ya-Dong
name: Mwachala, Geoffrey
name: Hu, Guang-Wan
name: Wang, Qing-Feng
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Cymbopogon
Cymbopogon caesius

description: Cymbopogon caesius (Hook. & Arn.) Stapf  —
Habit: Herb.
Habitat: LMDF; up to 2 300 m. Distribution: I.
Voucher: N/A.
Reference: Fries & Fries (1929).
description: Published as part of Zhou, Ya-Dong, Mwachala, Geoffrey, Hu, Guang-Wan & Wang, Qing-Feng, 2022, Annotated checklist of the vascular plants of Mount Kenya, East Africa, pp. 1-108 in Phytotaxa 546 (1) on page 36, DOI: 10.11646/phytotaxa.546.1.1, http://zenodo.org/record/6550464
Transmembrane self-assembled cyclic peptide nanotubes based on α‐residues and cyclic δ‐amino acids: a computational study
Creators: name: Blanco-González, Alexandre
name: Calvelo, Martín
name: F. Garrido, Pablo
name: García-Fandino, Rebeca
name: Piñeiro, Ángel
name: Granja, Juan
name: Amorín, Manuel
Publisher: name: Zenodo
Year: 2021
Subjects: Molecular Dynamics
Peptide Nanotubes
Transmembrane Transporters
Cyclic Peptides
Lipid Bilayers

description: In this work, we study peptide nanotubes comprised of α-amino acids and cyclic δ‐amino acids. Their stability when inserted in a lipid bilayer, as well as their utility as transmembrane channels is assesed, in order to elucidate their potential application as synthetic transmembrane channels; via Molecular Dynamics simulations.
description: This work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (PID2019-111126RB-100, RTI2018-098795-A-I00, and PID2019-111327GB-I00) and by the Xunta de Galicia and the ERDF (ED431F 2020/05, ED431C 2017/25, and Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09). M.C. thanks Xunta de Galicia for a predoctoral fellowship (ED481A-2017/ 068). R.G.-F. thanks Ministerio de Ciencia, Innovación y Universidades for a "Ramón y Cajal" contract (RYC-2016-20335). P. F. G. thanks the Spanish Ministry of Economy and Competitiveness and the EuropeanSocial Fund for his predoctoral research grant, reference BES-2016-076761. All calculations were carried out at the Centro de Supercomputación de Galicia
Additional file 1: of Indirect-comparison meta-analysis of treatment options for patients with refractory Kawasaki disease
Creators: name: Chan, Han
name: Chi, Huan
name: You, Hui
name: Wang, Mo
name: Gaofu Zhang
name: Haiping Yang
name: Li, Qiu
Publisher: name: figshare
Year: 2019
Subjects: subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Search strategy. (DOCX 16 kb)
Closed Loop Solitons and Sigma Functions: Classical and Quantized Elasticas with Genera One and Two
Creators: name: Matsutani, Shigeki
Publisher: name: arXiv
Year: 2000
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Closed loop solitons in a plane, whose curvatures obey the modified Korteweg-de Vries equation, were investigated. It was shown that their tangential vectors are expressed by ratio of Weierstrass sigma functions for genus one case and ratio of Baker's sigma functions for the genus two case. This study is closely related to classical and quantized elastica problems.
description: AMS-Tex Use 12 pages
title: Hydrothermale Umwandlungen im Rhyolith von Werbern (Halle'sche Mulde)
Creators: name: Reinsch, Dietmar
Publisher: name: Vieweg
Year: 1972
Subjects: subject: Brunsvicensien der Universitätsbibliothek Braunschweig
subject: Abhandlungen der BWG
subject: 50

description: Hydrothermale Umwandlungen (Chloritisierung, Verkieselungen, u. dgl.) des Ithyolithes lassen makroskopisch tuffartige Gesteine entstehen, die nur im Zusammenhang der fort-laufenden Bohrkerne als Rhyolithzersatz erkannt werden können. Durch intensive Verkieselungen, wahrscheinlich im Zusammenhang mit der Kaolinisierung der Rhyolithoberkante, entstehen z. T. sedimentähnliche Gesteine, die ebenfalls nur mikroskopisch von gleichfalls verkieselten, echten Sedimentzwischenlagen unterschieden werden können.
Additional file 11: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications
Creators: name: Jézéquel, Pascal
name: Kerdraon, Olivier
name: Hondermarck, Hubert
name: Guérin-Charbonnel, Catherine
name: Lasla, Hamza
name: Gouraud, Wilfried
name: Canon, Jean-Luc
name: Gombos, Andrea
name: Dalenc, Florence
name: Delaloge, Suzette
name: Lemonnier, Jérôme
name: Loussouarn, Delphine
name: Verrièle, Véronique
name: Campone, Mario
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Significant EFS analyses based on GES scores. (A) Internal and (B) external C2 and C3 TNBC patients. (PDF 103 kb)
An introduction to fractal uncertainty principle
Creators: name: Dyatlov, Semyon
Publisher: name: arXiv
Year: 2019
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Fractal uncertainty principle states that no function can be localized in both position and frequency near a fractal set. This article provides a review of recent developments on the fractal uncertainty principle and of their applications to quantum chaos, including lower bounds on mass of eigenfunctions on negatively curved surfaces and spectral gaps on convex co-compact hyperbolic surfaces.
description: 45+eps pages, 16 figures. To appear in Journal of Mathematical Physics
Kinetic Nearest Neighbor Search in Black-Box Model
Creators: name: sadeghi bigham, bahram
name: Nezami, Maryam
name: Eskandari, Marzieh
Publisher: name: figshare
Year: 2021
Subjects: Applied Computer Science
Theoretical Computer Science

description: Proximity problems is a class of important problems which involve estimation of distances between geometric objects. The nearest neighbor search which is a subset of proximity problems, arises in numerous fields of applications, including Pattern Recognition, Statistical classification, Computer vision and etc. In this study, a nearest neighbor search is presented to move points in the plane, while query point is static. The proposed method works in the black-box KDS model, in which the points location received at regular time steps while at the same time, an upper bound dmax is known on the maximum displacement of any point at each time step. In this paper, a new algorithm is presented for kinetic nearest neighbor search problem in the black-box model, under assumptions on the distribution of the moving point set P. It has been shown how the kinetic nearest neighbor will be updated at each time step in O(k∆k log n) amortized time, where ∆k is the k-spread of a point set P . Key words: Computational Geometry, Black Box Model, Kinetic, Nearest Neighbor.
Zero Modes of the Dirac Operator for regular Einstein-Yang-Mills Background fields
Creators: name: Brodbeck, Othmar
name: Straumann, Norbert
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The existence of normalizable zero modes of the twisted Dirac operator is proven for a class of static Einstein-Yang-Mills background fields with a half-integer Chern-Simons number. The proof holds for any gauge group and applies to Dirac spinors in an arbitrary representation of the gauge group. The class of background fields contains all regular, asymptotically flat, CP-symmetric configurations with a connection that is globally described by a time-independent spatial one-form which vanishes sufficiently fast at infinity. A subset is provided by all neutral, spherically symmetric configurations which satisfy a certain genericity condition, and for which the gauge potential is purely magnetic with real magnetic amplitudes.
description: 17 pages, LaTeX. Preprint archive number corrected and minor improvements of the text
title: Experimentelle Bestimmung der gebundenen Wirbellinien sowie des Strömungsverlaufs in der Umgebung der Hinterkante eines schlanken Deltaflügels
Creators: name: Hummel, Dietrich
name: Redeker, Günter
Publisher: name: Vieweg
Year: 1972
Subjects: subject: Brunsvicensien der Universitätsbibliothek Braunschweig
subject: Abhandlungen der BWG
subject: 629.1

description: Es wird über Grenzschichtmessungen an einem scharfkantigen schlanken Deltaflügel (Seitenverhältnis [Lambda] = 1,0, Anstellwinkel [alpha] = 20,5°) mit turbulenten Grenzschichten berichtet. Aus den Geschwindigkeiten am Rand der Grenzschicht auf Ober- und Unterseite ergibt sich der Verlauf der gebundenen Wirbellinien in der tragenden Fläche. Ein Vergleich mit früheren Untersuchungen bei laminaren Grenzschichten zeigt den Einfluß des Grenzschichtcharakters auf die Wirbelbildung. Untersuchungen über den Verlauf der Strömung stromabwärts von der Hinterkante lassen erkennen, daß sich die von der Hinterkante ausgehende Wirbelschceht zu einem Wirbel aufrollt, dessen Drehsinn dem des Vorderkantenwirbels entgegengesetzt ist. Die Achse dieses Hinterkantenwirbels verläuft spiralförmig um die Achse des Vorderkantenwirlwls.
Probing Cancer Targets and Therapeutic Mechanisms using Small Molecules
Creators: Zhang, Yan
Publisher: name: Columbia University
Year: 2019
Subjects: Chemistry
Biology
Computational chemistry
Therapeutics--Research
Cancer--Treatment
Oncogenes

description: Small molecules are a powerful tool to illuminate biological mechanisms and assist in the identification and validation of therapeutic targets. KRAS is the single most frequently mutated oncogene in human cancer, with particularly high mutation frequencies observed in pancreas (95%), colon (45%), and lung (35%) cancer. However, despite three decades of effort, there is no clinical viable KRAS cancer therapy. The first part of this thesis focuses on exploring the potential of directly targeting the KRAS nucleotide binding site. Directly targeting oncogenic KRAS with small molecules in the nucleotide-binding site has had limited success due to the high affinity of KRAS for nucleotide GTP and the high cellular concentration of GTP. The strategy of generating engineered KRAS allele based on shape and covalent complementarity was exploited herein to address this challenge. Using fragment-based small molecule design, a cell-membrane-permeable covalent inhibitor able to irreversibly modify the engineered nucleotide-binding site of KRAS was developed. The second part of this thesis describes the investigation of the therapeutic potential of imidazole ketone erastin (IKE), a small molecule inhibitor of the cystine/glutamate antiporter system xc–, in a subcutaneous xenograft model of Diffuse Large B Cell Lymphoma (DLBCL). A biodegradable polyethylene glycol-poly(lactic-co-glycolic acid) nanoparticle formulation was employed to aid in the delivery of IKE to cancer cells in vivo. This IKE nanoparticle system showed improved tumor accumulation and therapeutic index relative to free IKE, indicating its potential for treating DLBCL. The final part of this thesis describes the study of lipid metabolism features of ferroptotic cell death using quantitative reverse transcription PCR (RT-qPCR) and mass spectrometry-based lipidomic analysis. In summary, this work illustrates how chemistry and chemical biology approaches can supplement existing efforts towards the design and discovery of new drugs for challenging targets, as well as aid in the study of therapeutic mechanisms.
title: Für die Zukunft - Die UB Braunschweig sichert schriftliches Kulturgut
Creators: name: Brandes, Dietmar
Publisher: name: Universitätsbibliothek Braunschweig, 2012
Year: 2012
Subjects: subject: 025

description: Die Universitätsbibliothek Braunschweig besitzt überregional interessante Altbestände und ist darüber hinaus für einen langen Zeitabschnitt Archivbibliothek wichtiger deutscher Verlage. Die langfristige Sicherung dieses kulturellen Erbes ist jedoch mit erheblichem Aufwand verbunden. [...]
Probing Electronic and Thermoelectric Properties of Single Molecule Junctions
Creators: Widawsky, Jonathan R.
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Physics
subject: Nanotechnology
subject: FOS: Nanotechnology
subject: Quantum theory

description: In an effort to further understand electronic and thermoelectric phenomenon at the nanometer scale, we have studied the transport properties of single molecule junctions. To carry out these transport measurements, we use the scanning tunneling microscope-break junction (STM-BJ) technique, which involves the repeated formation and breakage of a metal point contact in an environment of the target molecule. Using this technique, we are able to create gaps that can trap the molecules, allowing us to sequentially and reproducibly create a large number of junctions. By applying a small bias across the junction, we can measure its conductance and learn about the transport mechanisms at the nanoscale. The experimental work presented here directly probes the transmission properties of single molecules through the systematic measurement of junction conductance (at low and high bias) and thermopower. We present measurements on a variety of molecular families and study how conductance depends on the character of the linkage (metal-molecule bond) and the nature of the molecular backbone. We start by describing a novel way to construct single molecule junctions by covalently connecting the molecular backbone to the electrodes. This eliminates the use of linking substituents, and as a result, the junction conductance increases substantially. Then, we compare transport across silicon chains (silanes) and saturated carbon chains (alkanes) while keeping the linkers the same and find a stark difference in their electronic transport properties. We extend our studies of molecular junctions by looking at two additional aspects of quantum transport - molecular thermopower and molecular current-voltage characteristics. Each of these additional parameters gives us further insight into transport properties at the nanoscale. Evaluating the junction thermopower allows us to determine the nature of charge carriers in the system and we demonstrate this by contrasting the measurement of amine-terminated and pyridine-terminated molecules (which exhibit hole transport and electron transport, respectively). We also report the thermopower of the highly conducting, covalently bound molecular junctions that we have recently been able to form, and learn that, because of their unique transport properties, the junction power factors, GS2, are extremely high. Finally, we discuss the measurement of molecular current-voltage curves and consider the electronic and physical effects of applying a large bias to the system. We conclude with a summary of the work discussed and an outlook on related scientific studies.
title: Why Twining?
Creators: name: Moulthrop, Stuart
name: Salter, Anastasia
Publisher: name: Electronic Book Review
Year: 2021

description: This except from Twining: Critical and Creative Approaches to Hypertext Narratives explores the popular and open-source digital storytelling platform Twine. Authors Anastasia Salter and Stuart Moulthrop discuss the history of Twine as well as existing works and possible projects.
A Machine Learning Framework for Biometric Authentication using Electrocardiogram
Creators: name: Kim, Song-Kyoo
name: Yeun, Chan Yeob
name: Damiani, Ernesto
name: Lo, Nai-Wei
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: This paper introduces a framework for how to appropriately adopt and adjust Machine Learning (ML) techniques used to construct Electrocardiogram (ECG) based biometric authentication schemes. The proposed framework can help investigators and developers on ECG based biometric authentication mechanisms define the boundaries of required datasets and get training data with good quality. To determine the boundaries of datasets, use case analysis is adopted. Based on various application scenarios on ECG based authentication, three distinct use cases (or authentication categories) are developed. With more qualified training data given to corresponding machine learning schemes, the precision on ML-based ECG biometric authentication mechanisms is increased in consequence. ECG time slicing technique with the R-peak anchoring is utilized in this framework to acquire ML training data with good quality. In the proposed framework four new measure metrics are introduced to evaluate the quality of ML training and testing data. In addition, a Matlab toolbox, containing all proposed mechanisms, metrics and sample data with demonstrations using various ML techniques, is developed and made publicly available for further investigation. For developing ML-based ECG biometric authentication, the proposed framework can guide researchers to prepare the proper ML setups and the ML training datasets along with three identified user case scenarios. For researchers adopting ML techniques to design new schemes in other research domains, the proposed framework is still useful for generating ML-based training and testing datasets with good quality and utilizing new measure metrics.
description: This paper has been published in the IEEE Access
Ectmesopus Blake 1940
Creators: name: Viswajyothi, Keezhpattillam
name: Clark, Shawn M.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Ectmesopus

description: Genus Ectmesopus Blake, 1940
Ectmesopus Blake, 1940: 96 (type species Ectmesopus darlingtoni Blake, 1940, by original designation).
Remarks
This genus contains 16 described species. They are all from the Greater Antilles. See Fig. 104 for a habitus illustration. See Blake (1958) for a key that includes most of the described species. However, realize that four species have been named subsequent to that key (Blake 1959, 1966a; Zayas 1988).
description: Published as part of Viswajyothi, Keezhpattillam & Clark, Shawn M., 2022, New World genera of Galerucinae Latreille, 1802 (tribes Galerucini Latreille, 1802, Metacyclini Chapuis, 1875, and Luperini Gistel, 1848): an annotated list and identification key (Coleoptera: Chrysomelidae), pp. 1-102 in European Journal of Taxonomy 842 on page 24, DOI: 10.5852/ejt.2022.842.1945, http://zenodo.org/record/7222499
Additional file 10: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications
Creators: name: Jézéquel, Pascal
name: Kerdraon, Olivier
name: Hondermarck, Hubert
name: Guérin-Charbonnel, Catherine
name: Lasla, Hamza
name: Gouraud, Wilfried
name: Canon, Jean-Luc
name: Gombos, Andrea
name: Dalenc, Florence
name: Delaloge, Suzette
name: Lemonnier, Jérôme
name: Loussouarn, Delphine
name: Verrièle, Véronique
name: Campone, Mario
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: Continuous score GES analyses result in function of internal TNBC clusters (C1, C2, and C3). (PDF 176 kb)
Ethics in medicine: a White Paper by the IAAT
Creators: name: Smith, Susan
name: Walter, Kevin C
name: Smith, Lucas
name: Balaskas, Alexandros
name: Adams, Jacob S
name: Lazar, Marius
name: Seideman, David
name: Husseini, Ibrahim
name: Davis, Alexander
name: Ernst, John
name: Mendez, Rosa
name: Papadopoulos, Anastasios
name: Diamandis, Carolina
Publisher: name: Zenodo
Year: 2021
Subjects: IAAT
International Association of Therapists & Medical Doctors
Ethics
Medicine
Quality
Malpractice prevention

description: Medicine has always reflected the behavior of its practitioners. It can look back on an impressive history with the Hippocratic Oath, which is approximately 2000 to 2500 years old. But despite this history, the question remains why there should be medical ethics or whether it is not sufficient to demand morally of a physician what is to be demanded of every citizen anyway.
Maintaining the Envelope of an Arrangement Fixed
Creators: name: Eskandari, Marzieh
name: Abedin, Marjan
Publisher: name: figshare
Year: 2021
Subjects: Applied Computer Science
Theoretical Computer Science

description: We present a simple algorithm for computing dual of the envelope polygon of an arrangement of n lines in dual space and then we present an algorithm for finding sets of lines that by adding them to the arrangement the envelope polygon of the primal arrangement remains fixed.
Asymptotic behaviour of a class of inhomogeneous scalar field cosmologies
Creators: name: Ibáñez, J.
name: Olasagasti, I.
Publisher: name: arXiv
Year: 1996
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The asymptotic behaviour of a class of inhomogeneous scalar field cosmologies with a Liouville type of potential is studied. We define a set of new variables for which the phase space of the system of Einstein equations is bounded. This allows us to perform a complete analysis of the evolution of these cosmologies. We also discuss the extension of the cosmic no-hair theorem.
description: 23 pages, latex, 3 figures, to appear in J. Math. Phys., figures also available tarred and gzip'ed at http://tp.lc.ehu.es/figures.gz
Cymbopogon nardus (L.) Rendle
Creators: name: Zhou, Ya-Dong
name: Mwachala, Geoffrey
name: Hu, Guang-Wan
name: Wang, Qing-Feng
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Cymbopogon
Cymbopogon nardus

description: Cymbopogon nardus (L.) Rendle  —
Habit: Herb.
Habitat: LMDF, HZ; up to 3 200 m. Distribution: I.
 Voucher: Chogoria Track, Alt. 3 123 m, 25 Jan. 2015, SAJIT 002848 (HIB).
References: Fries & Fries (1929), Young & Young (1983), Agnew (2013).
description: Published as part of Zhou, Ya-Dong, Mwachala, Geoffrey, Hu, Guang-Wan & Wang, Qing-Feng, 2022, Annotated checklist of the vascular plants of Mount Kenya, East Africa, pp. 1-108 in Phytotaxa 546 (1) on page 36, DOI: 10.11646/phytotaxa.546.1.1, http://zenodo.org/record/6550464
Detecting drug-drug interactions using artificial neural networks and classic graph similarity measures
Creators: name: Shtar, Guy
name: Rokach, Lior
name: Shapira, Bracha
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Quantitative Methods (q-bio.QM)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Drug-drug interactions are preventable causes of medical injuries and often result in doctor and emergency room visits. Computational techniques can be used to predict potential drug-drug interactions. We approach the drug-drug interaction prediction problem as a link prediction problem and present two novel methods for drug-drug interaction prediction based on artificial neural networks and factor propagation over graph nodes: adjacency matrix factorization (AMF) and adjacency matrix factorization with propagation (AMFP). We conduct a retrospective analysis by training our models on a previous release of the DrugBank database with 1,141 drugs and 45,296 drug-drug interactions and evaluate the results on a later version of DrugBank with 1,440 drugs and 248,146 drug-drug interactions. Additionally, we perform a holdout analysis using DrugBank. We report an area under the receiver operating characteristic curve score of 0.807 and 0.990 for the retrospective and holdout analyses respectively. Finally, we create an ensemble-based classifier using AMF, AMFP, and existing link prediction methods and obtain an area under the receiver operating characteristic curve of 0.814 and 0.991 for the retrospective and the holdout analyses. We demonstrate that AMF and AMFP provide state of the art results compared to existing methods and that the ensemble-based classifier improves the performance by combining various predictors. These results suggest that AMF, AMFP, and the proposed ensemble-based classifier can provide important information during drug development and regarding drug prescription given only partial or noisy data. These methods can also be used to solve other link prediction problems. Drug embeddings (compressed representations) created when training our models using the interaction network have been made public.
title: Über die Verwendung von Wechsellicht bei thermischen Strahlungsempfängern
Creators: name: Bauer, Georg
Publisher: name: Vieweg
Year: 1951
Subjects: subject: Brunsvicensien der Universitätsbibliothek Braunschweig
subject: Abhandlungen der BWG
subject: 530

description: The author shows by simple calculations that the radiation sensitivity of thermal receivers becomes about four times smaller if one operates the receiver with alternating light instead of constant light. But the smaller disturbances of the alternating light method and the possibility of using electronic amplifiers yield practically the same limit of accuracy as the method of constant light. The author gives some relations among the heat capacity, the heat transfer and the modulation frequency of resistance bolometers which should be attended to obtain the optimal sensitivity. This limit is still smaller for the alternating light method in comparison with constant light, where the thermal motion of the electrons dominates. Assuming plausible conditions for the band-width of the alternating light and the time of measure for constant light the accuracy of the alternating light bolometer becomes still diminished by the factor 5. So one concludes that the smallest detectable amount of radiation in relation to the disturbances is about 20 times smaller in the case of modulated light.
Additional file 4: of The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
Creators: name: Matteoni, Silvia
name: Abbruzzese, Claudia
name: Matarrese, Paola
name: Luca, Gabriele De
name: Mileo, Anna
name: Miccadei, Stefania
name: Schenone, Silvia
name: Musumeci, Francesca
name: Haas, Tobias
name: Sette, Giovanni
name: Carapella, Carmine
name: Amato, Rosario
name: Perrotti, Nicola
name: Signore, Michele
name: Paggi, Marco
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Figure S2. Clonogenic Assay. (PDF 440 kb)
2d quantum dilaton gravity as/versus finite dimensional quantum mechanical systems
Creators: name: Strobl, T.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: I present the ``Chern--Simons'' formulation of generalized 2d dilaton gravity, summarize its Hamiltonian quantization (reduced phase space and Dirac quantization) and briefly discuss the statistical mechanical entropy of 2d black holes. Focus is put on the close relation to finite dimensional point particle systems.
description: 4 pages, Latex; talk delivered at the 2nd Conference on Constrained Dynamics and Quantum Gravity, Santa Margherita Ligure, September 1996
Probing Heterogeneous Dynamics One Molecule at a Time: Polystyrene near the Glass Transition
Creators: Manz, Alyssa Sarah Jane Hennings
Publisher: name: Columbia University
Year: 2019
Subjects: Chemistry, Physical and theoretical
Materials science
Polystyrene
Polymers
Glass transition temperature
Dynamics

description: Polymeric systems near their glass transition are known to exhibit heterogeneous dynamics that evolve both over space and time, yet many of the underlying principles of these dynamics are still poorly understood. In this thesis, experimental single molecule studies aimed at uncovering the dynamics of polystyrene near its glass transition temperature are described. In a first approach, the influence of temperature on the timescales associated with dynamic heterogeneity – also referred to as exchange times – are identified by following the dynamics of a fluorescent perylene diimide probe embedded in a high-molecular weight polystyrene host. No clear influence on the lifetime of dynamics is found in the temperature regime Tg to Tg + 10 K. In a second study, heterogeneous dynamics are investigated in the context of molecular weight and fragility. In a similar experimental approach to that of the first study, two fluorescent dyes are utilized to report on the rotational dynamics of low- to high-molecular weight polystyrene hosts. In accordance with previous reports, the stretching exponent, β, is found to be correlated with the system’s molecular weight, even on a single molecule level. However, no clear correlation with the system’s exchange time was found. In a final study, several single molecule approaches aimed at uncovering the dynamics in confined polystyrene films are described. As no evidence for previously-described mobile surface molecules has been found, this final chapter is meant to provide a basis for future single molecule studies in confined systems.
The pattern speed of the Milky Way bar from transverse velocities
Creators: name: Sanders, Jason L.
name: Smith, Leigh
name: Evans, N. Wyn
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use the continuity equation to derive a method for measuring the pattern speed of the Milky Way's bar/bulge from proper motion data. The method has minimal assumptions but requires complete coverage of the non-axisymmetric component in two of the three Galactic coordinates. We apply our method to the proper motion data from a combination of Gaia DR2 and VISTA Variables in the Via Lactea (VVV) to measure the pattern speed of the bar as $Ω_\mathrm{p}=(41\pm 3)\,\mathrm{km\,s^{-1}\,kpc^{-1}}$ (where the error is statistical). This puts the corotation radius at $(5.7\pm0.4)\,\mathrm{kpc}$, under the assumptions of the standard peculiar motion of the Sun and the absence of non-axisymmetric streaming in the Solar neighbourhood. The obtained result uses only data on the near-side of the bar which produces consistent measurements of the distance and velocity of the centre of the Galaxy. Addition of the data on the far-side of the bar pulls the pattern speed down to $Ω_\mathrm{p}=(31\pm 1)\,\mathrm{km\,s^{-1}\,kpc^{-1}}$ but requires a lower transverse velocity for the Galactic centre than observed. This suggests systematics of $5-10\,\mathrm{km\,s^{-1}kpc^{-1}}$ dominate the uncertainty. We demonstrate using a dynamically-formed bar/bulge simulation that even with the limited field of view of the VVV survey our method robustly recovers the pattern speed.
description: 13 pages, 10 figures, updated to match MNRAS accepted version (new appendices on 1. generalising estimators to account for Sun's height above the plane and 2. validating choice of luminosity function)
Regular and Chaotic Dynamics of Triaxial Stellar Systems
Creators: name: Valluri, Monica
name: Merritt, David
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We use Laskar's frequency mapping technique to study the dynamics of triaxial galaxies with central density cusps and nuclear black holes. For ensembles of 10^4 orbits, we numerically compute the three fundamental frequencies of the motion, allowing us to map out the Arnold web. We also compute diffusion rates of stochastic orbits in frequency space. The objects of fundamental importance in structuring phase space are found to be the 3-dimensional resonant tori; even when stable, such tori are not necessarily associated with periodic orbits as in systems with only two degrees of freedom. Boxlike orbits are generically stochastic, but some tube orbits are stochastic as well. The spectrum of diffusion rates for box-like orbits at a given energy is well approximated as a power law over at least six decades. Models with high central concentrations -- steep central cusps or massive black holes -- exhibit the most stochasticity. A black hole with a mass of 0.3% the mass of the galaxy is as effective as the steepest central density cusp at inducing stochastic diffusion. There is a transition to global stochasticity in box-like phase space when the mass of a central black hole exceeds 2% the galaxy mass. We predict a greater average degree of dynamical evolution in faint ellipticals, due to their high central densities and short crossing times. The evolution time is estimated to be shorter than a galaxy lifetime for absolute magnitudes fainter than about -19 or -20, consistent with the observed change in many elliptical galaxy properties at this luminosity.
description: Revised version to appear in the Astrophysical Journal, vol 498, Oct 20 1998. Minor changes to text. References and 1 new figure added. 28 Latex pages, 22 Postscript figures, style file included