cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On semilocally simply connected spaces
Creators: name: Fischer, Hanspeter
name: Repovš, Dušan
name: Virk, Ziga
name: Zastrow, Andreas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 54D05 (Primary), 55Q05 (Secondary), 54G20, 54G15, 57M10, 55Q07

description: The purpose of this paper is: (i) to construct a space which is semilocally simply connected in the sense of Spanier even though its Spanier group is non-trivial; (ii) to propose a modification of the notion of a Spanier group so that via the modified Spanier group semilocal simple connectivity can be characterized; and (iii) to point out that with just a slightly modified definition of semilocal simple connectivity which is sometimes also used in literature, the classical Spanier group gives the correct characterization within the general class of path-connected topological spaces. While the condition "semilocally simply connected" plays a crucial role in classical covering theory, in generalized covering theory one needs to consider the condition "homotopically Hausdorff" instead. The paper also discusses which implications hold between all of the abovementioned conditions and, via the modified Spanier groups, it also unveils the weakest so far known algebraic characterization for the existence of generalized covering spaces as introduced by Fischer and Zastrow. For most of the implications, the paper also proves the non-reversibility by providing the corresponding examples. Some of them rely on spaces that are newly constructed in this paper.
description: 17 pages, 8 figures
title:   Comparing the Efficacy of Interventions Derived from Concurrent Operant Analysis and Indirect Assessment
Creators: name: Marquardt, Lane
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: In this study, a simultaneous treatments design was used to conduct a concurrent operant analysis (COA) to evaluate the choice making behavior of one elementary aged student. The COA results were used as a possible reinforcer for one of the conditions for the intervention to increase work completion. An indirect assessment, Questions about Behavioral Function (QABF), was used identify a hypothesized function to the student’s lack of task completion behavior. The results from thee QABD were used as a possible reinforcer for one of the conditions for the intervention to increase work completion. An alternating treatments design (ATD) was used to compare the percentage of work completion between the intervention derived from the COA results, the intervention derived from the QABF results, and how normal classroom sessions were conducted (baseline). Results from the COA showed that COAs could be conducted in the school setting and lead to an interpretable outcome. The results of the ATD showed that interventions derived from a COA and a QABF lead to a higher percentage of work completion, compared to baseline.
description: © 2023 Lane Marquardt
Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds
Creators: name: Farag, Ahmed K.
name: Hassan, Ahmed H. E.
name: Ahn, Byung Sun
name: Park, Ki Duk
name: Roh, Eun Joo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Hybridization of reported weakly active antiproliferative hit 5-amino-4-pyrimidinol derivative with 2-anilino-4-phenoxypyrimidines suggests a series of 2,5-diamino-4-pyrimidinol derivatives as potential antiproliferative agents. Few compounds belonging to the proposed series were reported as CSF1R/DAPK1 inhibitors as anti-tauopathies. However, the correlation between CSF1R/DAPK1 signalling pathways and cancer progression provides motives to reprofile them against cancer therapy. The compounds were synthesised, characterized, and evaluated against M-NFS-60 cells and a kinase panel which bolstered predictions of their antiproliferative activity and suggested the involvement of diverse molecular targets. Compound 6e, the most potent in the series, showed prominent broad-spectrum antiproliferative activity inhibiting the growth of hematological, NSCLC, colon, CNS, melanoma, ovarian, renal, prostate and breast cancers by 84.1, 52.79, 72.15, 66.34, 66.48, 51.55, 55.95, 61.85, and 60.87%, respectively. Additionally, it elicited an IC50 value of 1.97 µM against M-NFS-60 cells and good GIT absorption with Pe value of 19.0 ± 1.1 × 10−6 cm/s (PAMPA-GIT). Molecular docking study for 6e with CSF1R and DAPK1 was done to help to understand the binding mode with both kinases. Collectively, compound 6e could be a potential lead compound for further development of anticancer therapies.
Données, Systèmes d'information Généralisés - Apprentissage et Deep Learning
Creators: name: Roman-Jimenez, Geoffrey
name: Mothe, Josiane
Publisher: name: Zenodo
Year: 2018
Subjects: Deep Learning
Apprentissage
FabSpace 2.0

description: This presentation was given in June 2018 to present the research topics developped in the IRIT Lab Information team linked to deep learning, such as:

	Re-identification of vehicles/pedestrians in video surveillance by parsimonious encoding of latent spaces in deep networks
	Toulouse Campus Surveillance Dataset (TOCADA): a Dataset of video surveillance
	Help with diagnosis and prevention (cancer, dependency and age-related diseases)
	Calculations from satellite images (deforestation, population, water)
The Solar Neighborhood XXIV. Parallax Results from the CTIOPI 0.9-m Program: Stars with $μ$ $\ge$ 1\farcs0 yr$^{-1}$ (MOTION Sample) and Subdwarfs
Creators: name: Jao, Wei-Chun
name: Henry, Todd J.
name: Subasavage, John P.
name: Winters, Jennifer G.
name: Riedel, Adric R.
name: Ianna, Philip A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present 41 trigonometric parallaxes of 37 stellar systems, most of which have proper motions greater than 1\farcs0 yr$^{-1}$. These are the first trigonometric parallaxes for 24 systems. Overall, there are 15 red dwarf systems and 22 red subdwarf systems in the sample. Five of the systems are multiples with directly detected companions, and we have discovered perturbations caused by unseen companions in two additional cases, the dwarf LHS 501 and the subdwarf LHS 440. The latter system may eventually provide important dynamical mass points on the subdwarf mass-luminosity relation. Two additional stars of note are LHS 272, the third closest M-type subdwarf at a distance of only 13.6 pc, and LHS 2734AB, a high velocity subdwarf binary with $V_{tan}>$ 700 km/sec, which likely exceeds the escape velocity of the Milky Way. We also report the first long term variability study of cool subdwarfs indicating that cool subdwarfs are less photometrically variable than their main sequence counterparts.
description: 28 pages, 7 figures, 3 tables, accepted by AJ
Selection of the sex-linked Inhibitor of Apoptosis in Mountain Pine Beetle (Dendroctonus ponderosae) driven by enhanced expression during early overwintering
Creators: name: Horianopoulos, Linda C.; Boone, Celia K.; Samarasekera, Gayathri; Kandola, Gurkirat K.; Murray, Brent W.
Publisher: name: University of Alberta Libraries
Year: 2018

Abstract
title:   PHYSICAL ACTIVITY PREFERENCE AND PARTICIPATION IN MIDDLE SCHOOL AGE STUDENTS IN KENTUCKY
Creators: name: Correia, Fabian
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Physical activity (PA) in youth is significant as it begins to lay the fountain for a healthier lifestyle as children age. The benefits of being regularly physically active are plentiful as it improves muscle strength, cardiovascular, fitness, and cognitive functions (Rodgers, 2008). However, oftentimes in physical education classes, the voice of the student tends to go unheard. The purpose of this study was to determine how the perception or preference to be physically active differs by age, gender, and/or ethnicity in a middle school setting. The goal of this study is to shed ligt on how building a more inclusive and student-driven (PE) curriculum may improve participation. The significance of this study would be the potential to improve students’ PA levels through enjoyment and awareness of activities. Focusing on activities students prefer to participate in during class may lead to a more positive perception of PA, potentially, leading to lifelong PA engagement.

Participants completed the validated PEAS (Orlic et al., 2017), modified for this study, along with a list of the activities offered in their regular PE curriculum. The surveys used a 5-point Likert scale ranging from strongly prefer (5) the activity/statement to strongly dislike (1) the activity/statement. Data were analyzed using SPSS to provide descriptive statistics via a Chi-Square Test. Data were grouped by age, gender, or ethnicity using the different activities or statements to compare and contrast. The PEAS measured four dimensions: Satisfaction, Comfort, Activity, and Teacher, while the second survey divided items into three groups: Team sports, Individual Sports, and Leisure activities.

The results when determined using Chi- Square resigns to show significance in multiple areas, the most prominent being in gender and ethnicity. Gender played a large role in students feeling uncomfortable and be unsatisfied with their current PE classes. Ethnicity was mainly a factor in students preferring individual sports above all else.
description: © 2023 Fabian Correia
Seasonal shifts in accumulation of glycerol biosynthetic gene transcripts in mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae), larvae
Creators: name: Fraser, Jordie D.; Bonnett, Tiffany R.; Keeling, Christopher I.; Huber, Dezene P.W.
Publisher: name: University of Alberta Libraries
Year: 2017

Abstract
Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies
Creators: name: Al-Warhi, Tarfah
name: Abo-Ashour, Mahmoud F.
name: Almahli, Hadia
name: Alotaibi, Ohoud J.
name: Al-Sanea, Mohammad M.
name: Al-Ansary, Ghada H.
name: Ahmed, Hanaa Y.
name: Elaasser, Mahmoud M.
name: Eldehna, Wagdy M.
name: Abdel-Aziz, Hatem A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates (7, 8a–c, 9 and 10a–e) is here designed and synthesised with the prime aim to develop more efficient isatin-based antitumor candidates. Utilising the SAR outputs from the previous study, our design here is based on appending four alkyl groups with different length (ethyl and n-propyl), bulkiness (iso-propyl) and unsaturation (allyl) on N-1 of indole motif, with subsequent conjugation with different N-unsubstituted isatin moieties to furnish the target conjugates. As planned, the adopted strategy achieved a substantial improvement in the growth inhibitory profile for the target conjugates in comparison to the reported lead VI. The best results were obtained with N-propylindole –5-methylisatin hybrid 8a which displayed broad spectrum anti-proliferative action with efficient sub-panel GI50 (MG-MID) range from 1.33 to 4.23 µM, and promising full-panel GI50 (MG-MID) equals 3.10 µM, at the NCI five-dose assay. Also, hybrid 8a was able to provoke cell cycle disturbance and apoptosis in breast T-47D cells as evidenced by the DNA flow cytometry and Annexin V-FITC/PI assays. Furthermore, hybrid 8a exhibited good inhibitory action against cell cycle regulator CDK2 protein kinase and the anti-apoptotic Bcl-2 protein (IC50= 0.85 ± 0.03 and 0.46 ± 0.02 µM, respectively). Interestingly, molecular docking for hybrid 8a in CDK2 and Bcl-2 active sites unveiled that N-propyl group is involved in significant hydrophobic interactions. Taken together, the results suggested conjugate 8a as a promising lead for further development and optimisation as an efficient antitumor drug.
Single-electron transistor fabricated by focused laser beam-induced doping of a GaAs/AlGaAs heterostructure
Creators: name: Baumgartner, P.
name: Wegscheider, Werner
name: Bichler, Max
name: Schedelbeck, G.
name: Neumann, Richard
name: Abstreiter, Gerhard
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 530 Physik

description: A single-electron transistor has been fabricated by an optical fabrication method. A small dot, a source and drain reservoir, and in-plane gates are all built from the two-dimensional electron gas of an n-type GaAs/AlGaAs heterostructure. Laser-written p-doped lines are used to define this dot with a diameter of about 70 nm and to insulate it from the in-plane gates. Tunnel junctions connect the dot with source and drain. The in-plane gates are used to tune the tunnel junctions and to change the electrostatic potential of the dot. A large charging energy of 5 meV and clear Coulomb-blockade oscillations are observed at helium temperature, due to a small dot capacitance of about 3 × 10–17 F.
Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
Creators: name: Stasiłowicz, Anna
name: Tykarska, Ewa
name: Lewandowska, Kornelia
name: Kozak, Maciej
name: Miklaszewski, Andrzej
name: Kobus-Cisowska, Joanna
name: Szymanowska, Daria
name: Plech, Tomasz
name: Jenczyk, Jacek
name: Cielecka-Piontek, Judyta
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.
The magnetosphere of the ultracool dwarf DENIS 1048-3956
Creators: name: Ravi, V.
name: Hallinan, G.
name: Hobbs, G.
name: Champion, D. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Ultracool dwarfs, the least-massive contributors to the stellar mass function, exhibit striking magnetic properties that are inconsistent with trends for more massive stars. Here, we present the widest-band radio observations to date of an ultracool dwarf, DENIS-P J104814.9-395604, in four 2 GHz bandwidths between wavelengths of 1 cm and 10 cm. These data were obtained with the Australia Telescope Compact Array using the new Compact Array Broadband Backend instrument. We detected a stable negatively-sloped power-law spectrum in total intensity, with spectral index alpha=1.71+-0.09. Circular polarization fractions between 0.25 and 0.4 were found at the low-frequency end of our detection band. We interpret these results as indicative of gyrosynchrotron emission. We suggest that the radio emission originates from beyond the co-rotation radius, R_C, of the star. Adopting this model, we find R_C between 1.2-2.9 R_*, and a non-thermal electron density and magnetic field strength between 10^(5)-10^(7.2) cm^(-3) and 70-260 G respectively at R_C. The model accounts for the violation of the Guedel-Benz relation between X-ray and radio luminosities of low-mass stars by DENIS-P J104814.9-395604.
description: Accepted for publication in ApJL -- 5 pages, 2 figures
Modeling the transverse momentum dependent parton distributions
Creators: name: Pasquini, B.
name: Lorce', C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We review quark model calculations of the transverse momentum dependent parton distributions (TMDs). For the T-even TMDs, we discuss the physical origin of model relations which hold in a large class of quark models. For the T-odd TMDs we review results in a light-cone constituent quark model (CQM) with the final state interaction effects generated via single-gluon exchange mechanism. As phenomenological application, we show the good agreement between results in the light-cone CQM and available experimental data for the Collins asymmetry.
description: 8 pages, 2 figures, 2 tables; invited talk at "The 4th Workshop on Exclusive Reactions at High Momentum Transfer", Jefferson Lab., May 18-21, 2010
Photonic Crystals with Controlled Disorder
Creators: name: Garcia, P. D.
name: Sapienza, R.
name: Toninelli, C.
name: Lopez, C.
name: Wiersma, D. S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Photonic crystals are extremely sensitive to structural disorder even to the point of completely losing their functionalities. While on one side this can be detrimental for applications in traditional optical devices, on the other side, it gives also rise to very interesting new physics and maybe even new applications. We propose a route to introduce disorder in photonic crystals in a controlled way, by creating a certain percentage of vacancies in the lattice. We show how the method works and what type of materials can be obtained this way. Also we characterize the resulting transport properties from various points of view, including measurements of the transport and scattering mean free path and the diffusion constant.
title:   Comparison of Botanical Composition Methods and Change Over Time in Kentucky Pastures
Creators: name: Gotsick, Echo
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: subject: FOS: Agricultural sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Botanical composition of pastures has been measured with numerous methods over the last century, but there have been limited direct comparisons between methods. The objective of this study was to compare botanical composition methods, to determine the most accurate and efficient method, and to access pasture composition change over time. Six farms with two pastures each were monitored across the state of Kentucky. Sampling occurred fall 2020 through fall 2022, three times a year using the following methods: step point, visual estimation, occupancy grid, and point quadrat (used as a reference method). The occupancy grid showed the highest similarity to the point quadrat method, was less prone to over and under-estimation, and had the highest correlation coefficient, 0.87 to 0.99 across all species. The correlation across species between the point quadrat and visual estimation was 0.75 to 0.98 and 0.40 to 0.90 with the step point method. Monitoring of species change over time showed an expected shift from C3 to C4 species during the warmer months of the growing season, but this shift was most dramatic under drought conditions and overgrazing. Drought conditions caused a significant (p = < 0.05) increase in C4 species during the final two sampling periods. These conditions confounded with less-than-ideal management strategies caused estimated dry matter yield to decline over the study period. In conclusion, occupancy grid was most similar to point quadrat method and was the most efficient method of botanical analysis. C3 and C4 species change over time was most affected by climate and pasture management.
description: © 2023 Echo Elizabeth Gotsick
Halococcoides cellulosivorans Sorokin & Khijniak & Elcheninov & Toshchakov & Kostrikina & Bale & Sinninghe Damsté & Kublanov 2019, SP. NOV.
Creators: name: Sorokin, Dimitry Y.
name: Khijniak, Tatiana V.
name: Elcheninov, Alexander G.
name: Toshchakov, Stepan V.
name: Kostrikina, Nadezhda A.
name: Bale, Nicole J.
name: Sinninghe Damsté, Jaap S.
name: Kublanov, Ilya V.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Archaea
Euryarchaeota
Halobacteria
Halobacteriales
Haloarculaceae
Halococcoides
Halococcoides cellulosivorans

description: DESCRIPTION OF HALOCOCCOIDES CELLULOSIVORANS SP. NOV.
 Halococcoides cellulosivorans (cel.lu.lo.si.vo′ rans N.L. neut. n. cellulosum, cellulose; L. pres. part. vorans, devouring; N.L. part. adj. cellulosivorans, cellulose-devouring).
 Cells are non-motile cocci, 0.8–3 µm, with a thin monolayer cell wall. The colonies on amorphous cellulose agar are flat, up to 1 mm, soft and slightly orange. It is a strictly aerobic (catalase/oxidase positive) saccharolytic specialized on utilization of native forms of insoluble cellulose and xylan. Cellobiose is the only soluble sugar utilized for growth. The nitrogen source is ammonium. Nitrate and urea are not utilized. Does not grow anaerobically either by fermentation or anaerobic respiration. Does not utilize organic acids or organic nitrogen compounds as carbon and energy source. High Mg is not required for growth. Proteolytic and lipolytic activity are absent. Strain HArcel1 T is an extremely halophilic neutrophile, with the NaCl range for growth between 3 and 5 M (optimum at 3.5–4 M) and the pH range from 6.5 to 8.0 (optimum, pH 7.0–7.2). The maximum growth temperature at 4 M NaCl with cellobiose as substrate is 50 Ǫ C (optimum, 40–42 Ǫ C). The core membrane lipids are dominated by C 20 - C 20 and C 25 -C 20 DGE with 1 C 25 MGE and 2 C 20 MGE as minor components. The identified intact membrane polar lipids include PGP-Me and PG as major components, and diglycosyl diether glycolipid and phosphatidylglycerol sulfate sulfolipid as minor components. The G +C content of the genomic DNA in the type strain is 65.74 mol% (genome). The habitat is hypersaline lakes with near-neutral pH.
 The type strain is HArcel1 T =JCM 31941 T =UNIQEM U975 T. The full genome accession number in the GenBank is CP028858.
description: Published as part of Sorokin, Dimitry Y., Khijniak, Tatiana V., Elcheninov, Alexander G., Toshchakov, Stepan V., Kostrikina, Nadezhda A., Bale, Nicole J., Sinninghe Damsté, Jaap S. & Kublanov, Ilya V., 2019, Halococcoides cellulosivorans gen. nov., sp. nov., an extremely halophilic cellulose-utilizing haloarchaeon from hypersaline lakes, pp. 1327-1335 in International Journal of Systematic and Evolutionary Microbiology 69 (5) on page 1334, DOI: 10.1099/ijsem.0.003312, http://zenodo.org/record/6223836
On statistical uncertainty in nested sampling
Creators: name: Keeton, Charles R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Computation (stat.CO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Nested sampling has emerged as a valuable tool for Bayesian analysis, in particular for determining the Bayesian evidence. The method is based on a specific type of random sampling of the likelihood function and prior volume of the parameter space. I study the statistical uncertainty in the evidence computed with nested sampling. I examine the uncertainty estimator from Skilling (2004, 2006) and introduce a new estimator based on a detailed analysis of the statistical properties of nested sampling. Both perform well in test cases and make it possible to obtain the statistical uncertainty in the evidence with no additional computational cost.
description: 9 pages, 4 figures; accepted to MNRAS
Luteithermobacter gelatinilyticus Park & Namirimu & Yang & Kwon 2020, SP. NOV.
Creators: name: Park, Mi-Jeong
name: Namirimu, Teddy
name: Yang, Sung-Hyun
name: Kwon, Kae Kyoung
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Bacteria
Proteobacteria
Alphaproteobacteria
Sphingomonadales
Emcibacteraceae
Luteithermobacter
Luteithermobacter gelatinilyticus

description: DESCRIPTION OF LUTEITHERMOBACTER GELATINILYTICUS SP. NOV.
 Luteithermobacter gelatinilyticus (ge.la.ti.ni.ly′ ti.cus. N.L. neut. n. gelatinum gelatin; Gr. masc. adj. lytikos able to dissolve; N.L. masc. adj. lyticus dissolving; N.L. masc. adj. gelatinilyticus gelatin-dissolving).
 Cells are rod-shaped with a width of 0.4–0.5 µm and length of 1.5–2 µm. Colonies are 3 mm in diameter and pale yellow, with a circular, convex, entire edge, and a glistening surface on MA after 3 days of cultivation. Growth is observed at 35–59 °C (optimum 55 °C), at pH 6.0–9.0 (optimum pH 6.0) and with 1–9% (w/v) NaCl (optimum 2.5–3.5%) in the presence of KCl, MgCl 2 and CaCl 2. Nitrate is reduced to nitrite. Negative for indole production and cannot assimilate aesculin, p -NP(nitrophenyl)-galactopyranoside or urea. However, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, L-leucyl-2-naphthylamide,L-valyl-2-naphthylamide, L -cystyl-2-naphthylamide, 2-naphthyl phosphate, naphthol-AS- BI- phosphate, dextrin, cellobiose, turanose, lactose, D-fructose, D -sorbitol, D-arabitol, myo -inositol,D-fructose 6-phosphate, D -aspartic acid, gelatin, L-arginine,L-histidine,L-serine, pectin, D -galacturonic acid,L-galactonic acid lactone,D-glucuronic acid, glucuronamide, p -hydroxy-phenylacetic acid, methyl pyruvate, D-lactic acid methyl ester, α-ketobutyric acid, acetoacetic acid, propionic acid, acetic acid and formic acid can be assimilated. The major fatty acids include C 14:0, C 16:0, C ω6 c, C 19:0 cyclo ω8 c, C 2-OH, summed feature 3 (C 16:1 ω6 c and/or C 16:1 ω7 c) and summed feature 8 (C 18:1 ω7 c and/or C 18:1 ω6 c). The predominant polar lipids include phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, an unidentified phospholipid, three unidentified aminolipids and two unidentified lipids.
 17:1
 14:0
 The type strain, MEBiC09520 T (=KCCM 43320 T =MCCC 1 K03920 T), was isolated from a tidal sediment of Buksung- Po, Incheon, South Korea. The DNA G+C content of the type strain is 54.7 mol%. The GenBank/EMBL/MMBJ accession number for the 16S rRNA gene sequence is MK878394 and that of the genome sequence is CP040517.
description: Published as part of Park, Mi-Jeong, Namirimu, Teddy, Yang, Sung-Hyun & Kwon, Kae Kyoung, 2020, Description of Luteithermobacter gelatinilyticus gen. nov., sp. nov., and Paremcibacter congregatus gen. nov., comb. nov. via reclassification of the genus Emcibacter, pp. 4691-4697 in International Journal of Systematic and Evolutionary Microbiology 70 (8) on page 4695, DOI: 10.1099/ijsem.0.004334, http://zenodo.org/record/6224005
Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening
Creators: name: Floresta, Giuseppe
name: Crocetti, Letizia
name: Giovannoni, Maria Paola
name: Biagini, Pierfrancesco
name: Cilibrizzi, Agostino
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: We report here in silico repurposing studies on 52 new pyridazinone-based small-molecules through inverse virtual screening (iVS) methodologies. These analogues were originally designed as formyl peptide receptor (FPR) ligands. As it is sometimes the case in drug discovery programmes, subsequent biological screening demonstrated the inefficacy of the molecules in binding FPRs, failing in the identification of new hits. Through a focussed drug-repurposing approach we have defined a variety of potential targets that are suitable to interact with this library of pyridazinone-based analogues. A two-step approach has been conducted for computational analysis. Specifically, the molecules were initially processed through a pharmacophore-based screening. Secondly, the resulting features of binding were investigated by docking studies and following molecular dynamic simulations, in order to univocally confirm “pyridazinone-based ligand-target protein” interactions. Our findings propose aspartate aminotransferase as the most favourable repurposed target for this small-molecule series, worth of additional medicinal chemistry investigations in the field.
Lateral superlattices as voltage-controlled traps for excitons
Creators: name: Zimmermann, S.
name: Govorov, A. O.
name: Hansen, W.
name: Kotthaus, J.
name: Bichler, Max
name: Wegscheider, Werner
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 530 Physik
subject: 71.55.Eq, 71.35.Ji

description: We demonstrate the localization of quantum-well excitons in a periodic array of linear traps using photoluminescence experiments. The excitonic traps are induced by applying spatially alternating external voltages via interdigitated metal gates. The localization originates from the periodical modulation of the strength of the quantum-confined Stark effect in the plane of the quantum well. In our experiments, the trap depth is easily tuned by the voltages applied to the interdigitated gates. Furthermore, we find that a perpendicular magnetic field reduces the exciton diffusion length. In short-period lateral superlattices, we observe a magnetic-field-induced stabilization of excitons in the presence of strong in-plane electric fields.
Additional file 1: of Early development of infants with neurofibromatosis type 1: a case series
Creators: name: Kolesnik, Anna
name: Jones, Emily
name: Garg, Shruti
name: Green, Jonathan
name: Charman, Tony
name: Johnson, Mark
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: SM1 - Social Engagment Scale; SM2 - Clinical Assessment; SM Table 1 - Participant descriptive data and the assessments carried out for each group; SM Table 2 - Standardised scores from the Mullen Scale for infants with NF1 (cases 1-10), infants with later ASD, and typically developing controls; SM Table 3 - Standardized scores for the subscales and a composite score from the Vineland Adaptive Behavior Scale; SM Table 4 - Infant Behavior Questionnaire scores for 14 subscales and 3 domain scales; SM Table 5 - Sensory Sensitivity rated through the Infant/Toddler Sensitivity Profile for infants with NF1; SM Table 6 - Experimenter-rated Social Engagement scores for infants with NF1; SM Table 7 - Scores on the individual AOSI items, separated by sensory-motor and social abilities for infants with NF1. (DOCX 233Â kb)
Numerical estimation of discretization error on unstructured meshes
Creators: name: Yan, Kai Kin Gary
Publisher: name: University of British Columbia
Year: 2018

description: A numerical estimation of discretization error is performed for solutions to steady and unsteady models for compressible flow. An accurate and reliable estimate of discretization error is useful in obtaining a more accurate defect corrected solution, as well as a tight uncertainty bound as error bars. The error estimation procedure is performed by solving an auxiliary problem, known as the error transport equation (ETE), solved on the same mesh as the original model equations. Unlike unsteady adjoint methods for error in functionals, the ETE requires only one other set of equations to be solved, agnostic to the choice and number of output functionals, including common aerodynamic quantities such as lift or drag. Furthermore, co-advancing the ETE in time only requires the storage of local solutions in time and not the entire history, reducing memory requirements. This method of error estimation is performed in the context of higher order finite-volume methods on unstructured meshes. Approaches based on solving the ETE can be found in the literature for uniform or smooth meshes, but this has not been well studied for unstructured meshes. Such meshes necessarily have nonsmooth geometric features, which create many difficulties in accurate error estimation. These difficulties in accurate discretizations of the ETE are investigated, including the discretization of the ETE source term, which is critical to error estimate accuracy. It was found that the proposed schemes by the ETE approach can be more efficient and robust compared to solving the higher order problem. The choices of discretization schemes need to be made carefully, and these results demonstrate how it is possible, along with justification, to obtain asymptotically accurate, efficient, and robust error estimates that can be used with vast possibilities of model equations in practice.
Bags and Confinement Governed by S.S.B. of Scale Invariance
Creators: name: Guendelman, E. I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A general coordinate invariant theory is constructed where confinement of gauge fields and gauge dynamics in general is governed by the spontaneous symmetry breaking (s.s.b.) of scale invariance. The model uses two measures of integration in the action, the standard $\sqrt{-g}$ where $g$ is the determinant of the metric and another measure $Φ$ independent of the metric. To implement scale invariance (S.I.), a dilaton field is introduced. Using the first order formalism, curvature ( $ΦR$ and $\sqrt{-g}R^{2}$ ) terms , gauge field term and dilaton kinetic terms are introduced in a conformally invariant way. Exponential potentials for the dilaton break down (softly) the conformal invariance down to global scale invariance, which also suffers s.s.b. after integrating the equations of motion. The model has a well defined flat space limit. As a result of the s.s.b. of scale invariance phases with different vacuum energy density appear. Inside the bags, that is in the regions of larger vacuum energy density, the gauge dynamics is normal, that is non confining, while for the region of smaller vacuum energy density, the gauge field dynamics is confining. Likewise, the dynamics of scalars, like would be Goldstone bosons, is suppressed inside the bags.
description: 32 pages
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity
Creators: name: Krasavin, Mikhail
name: Sharonova, Tatiana
name: Sharoyko, Vladimir
name: Zhukovsky, Daniil
name: Kalinin, Stanislav
name: Žalubovskis, Raivis
name: Tennikova, Tatiana
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: A hypothesis that simultaneous targeting cancer-related carbonic anhydrase hCA IX and hCA XII isoforms (whose overexpression is a cancer cell’s defence mechanism against hypoxia) along with thioredoxin reductase (overexpressed in cancers as a defence against oxidative stress) may lead to synergistic antiproliferative effects was confirmed by testing combinations of the two inhibitor classes against pancreatic cancer cells (PANC-1). Combining both pharmacophoric motifs within one molecule led to a sharp increase of cytotoxicity. This preliminary observation sets the ground for a fundamentally new approach to anticancer agent design.
Spin Transport in Cold Fermi gases: A Pseudogap Interpretation of Spin Diffusion Experiments at Unitarity
Creators: name: Wulin, Dan
name: Guo, Hao
name: Chien, Chih-Chun
name: Levin, Kathryn
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We address recent spin transport experiments in ultracold unitary Fermi gases. We provide a theoretical understanding for how the measured temperature dependence of the spin diffusivity at low $T$ can disagree with the expected behavior of a Fermi liquid (FL) while the spin susceptiblity(following the experimental protocols) is consistent with a Fermi liquid picture. We show that the experimental protocols for extracting $χ_s$ are based on a FL presumption; relaxing this leads to consistency within (but not proof of) a pseudogap-based approach. Our tranport calculations yield insight into the measured strong suppression of the spin diffusion constant at lower $T$.
description: 4 pages, 2 figures
title: Elektrostatische Aufladungen in Druckmaschinen
Creators: name: Scheuter, Karl R.
name: Eschenbach, Wolfram
name: Fritsch, Klaus
Publisher: name: UNSPECIFIED
Year: 1966

description: Durch systemmische Messungen in Druckmaschinen, speziell in Rollenrotations-Tiefdruckmaschinen, wurde versucht, Quellen und Ursachen der elektrostatischen AufladUng der Papierbahn exakt zu erfassen. Anhand typischer Meßergebnisse werden die Einrtisse der verschiedenen Parameter, die die Entstehung der elektrostatischen Aufladung beeinflussen, erläutert. Druckgeschwindigkeit, Anpreßdruck und Raum- und Maschinentemperatur sowie die verschiedenen Materialien, die die Papierbahn berühren, sind maßgeblich. Bei allen Messungen zeigt sich der große Einfluß der Druckfarbe ( Farbmenge und Farbverteilung) auf die Entstehung der elektrostatischen Aufladung. Der Farbübertragungsprozeß wird entscheidend durch die elektrostatische Aufladung beeinflußt. Wie Versuche ergaben, kann durch eine geeignete Ladungsverteilung die Farbübertragung verbessert werden.
Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors
Creators: name: Sağlık, Begüm Nurpelin
name: Osmaniye, Derya
name: Çevik, Ulviye Acar
name: Levent, Serkan
name: Çavuşoğlu, Betül Kaya
name: Eklioğlu, Özlem Atlı
name: Özkay, Yusuf
name: Koparal, Ali Savaş
name: Kaplancıklı, Zafer Asım
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Many studies have been conducted on the selective inhibition of human monoamine oxidase B (hMAO-B) enzyme using benzylamine-sulphonamide derivatives. Using various chemical modifications on BB-4h, which was reported previously by our team and showed a significant level of MAO-B inhibition, novel benzylamine-sulphonamide derivatives were designed, synthesised, and their MAO inhibition potentials were evaluated. Among the tested derivatives, compounds 4i and 4t achieved IC50 values of 0.041 ± 0.001 µM and 0.065 ± 0.002 µM, respectively. The mechanism of hMAO-B inhibition by compounds 4i and 4t was studied using Lineweaver–Burk plot. The nature of inhibition was also determined to be non-competitive. Cytotoxicity tests were conducted and compounds 4i and 4t were found to be non-toxic. Molecular docking studies were also carried out for compound 4i, which was found as the most potent agent, within hMAO-B catalytic site.
Classification of matrix product ground states corresponding to one dimensional chains of two state sites of nearest neighbor interactions
Creators: name: Fatollahi, Amir H.
name: Khorrami, Mohammad
name: Shariati, Ahmad
name: Aghamohammadi, Amir
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A complete classification is given for one dimensional chains with nearest neighbor interactions having two states in each site, for which a matrix product ground state exists. The Hamiltonians and their corresponding matrix product ground states are explicitly obtained.
description: 17 pages, LaTeX2e
On commuting matrices in max algebra and in classical nonnegative algebra
Creators: name: Katz, Ricardo D.
name: Schneider, Hans
name: Sergeev, Sergei
Publisher: name: arXiv
Year: 2010
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 15A80, 15B48 (Primary) 15A27, 15A18 (Secondary)

description: This paper studies commuting matrices in max algebra and nonnegative linear algebra. Our starting point is the existence of a common eigenvector, which directly leads to max analogues of some classical results for complex matrices. We also investigate Frobenius normal forms of commuting matrices, particularly when the Perron roots of the components are distinct. For the case of max algebra, we show how the intersection of eigencones of commuting matrices can be described, and we consider connections with Boolean algebra which enables us to prove that two commuting irreducible matrices in max algebra have a common eigennode.
description: 18 pages
Design and analysis of computer experiments : assessing and advancing the state of the art
Creators: name: Chen, Hao
Publisher: name: University of British Columbia
Year: 2018

description: Computer experiments have been widely used in practice as important supplements to traditional laboratory-based physical experiments in studying complex processes. However, a computer experiment, which in general is based on a computer model with limited runs, is expensive in terms of its computational time. Sacks.et.al. (1989) proposed to use Gaussian process (GP) as a statistical surrogate, which has become a standard way to emulate a computer model. In the thesis, we are concerned with design and analysis of computer experiments based on a GP. We argue that comprehensive, evidence-based assessment strategies are needed when comparing different model options and designs. We first focus on the regression component and the correlation structure of a GP. We use comprehensive assessment strategies to evaluate the effect of the two factors on the prediction accuracy. We also have a limited evaluation on empirical Bayes methods and full Bayes methods, from which we notice Bayes methods with a squared exponential structure do not yield satisfying prediction accuracy in some examples considered. Hence, we propose to use hybrid and full Bayes methods with flexible structures. Through empirical studies, we show the new Bayes methods with flexible structures not only have better prediction accuracy, but also have a better quantification of uncertainty. In addition, we are interested in assessing the effect of design on prediction accuracy. We consider a number of popular designs in the literature and use several examples to evaluate their performances. It turns out the performance difference between designs is small for most of the examples considered. From the evaluation of designs, we are motivated to use a sequential design strategy. We compare the performances of two existing sequential search criteria and handle several important issues in using the sequential design to estimate an extreme probability/quantile of a floor supporting system. Several useful recommendations have also been made.
MPEC 2023-J10 : 2023 HQ7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 HQ7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Molecular Model of the Contractile Ring
Creators: name: Biron, D.
name: Alvarez-Lacalle, E.
name: Tlusty, Tsvi
name: Moses, Elisha
Publisher: name: arXiv
Year: 2010
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction. We demonstrate the crucial role of actin polymerization and depolymerization throughout cytokinesis, and the dominance of viscous dissipation in the dynamics. The physical origin of two phases in cytokinesis dynamics ("biphasic cytokinesis") follows from a limitation on the actin density. The model is consistent with a wide range of measurements of the midzone of dividing animal cells.
description: PACS numbers: 87.16.Ka, 87.16.Ac http://www.ncbi.nlm.nih.gov/pubmed/16197254 http://www.weizmann.ac.il/complex/tlusty/papers/PhysRevLett2005.pdf
Spontaneous separation of two-component Fermi gases in a double-well trap
Creators: name: Xu, Junjun
name: Gu, Qiang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The two-component Fermi gas in a double-well trap is studied using the density functional theory and the density profile of each component is calculated within the Thomas-Fermi approximation. We show that the two components are spatially separate in the two wells once the repulsive interaction exceeds the Stoner point, signaling the occurrence of the ferromagnetic transition. Therefore, the double-well trap helps to explore itinerant ferromagnetism in atomic Fermi gases, since the spontaneous separation can be examined by measuring component populations in one well.
description: 6 pages, 6 figures, to appear in epl
Threshold-improved predictions for charm production in deep-inelastic scattering
Creators: name: Presti, N. A. Lo
name: Kawamura, H.
name: Moch, S.
name: Vogt, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We have extended previous results on the threshold expansion of the gluon coefficient function for the charm contribution to the deep-inelastic structure function F_2 by deriving all threshold-enhanced contributions at the next-to-next-to-leading order. The size of these corrections is briefly illustrated, and a first step towards extending this improvement to more differential charm-production cross sections is presented.
description: 6 pages, LaTeX (PoS style), 3 eps-figures. Presented by N.A.L.P. at DIS 2001, Florence (Italy), April 2010. To appear in the proceedings