cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Non-representative quantum mechanical weak values
Creators: name: Svensson, B. E. Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The operational definition of a weak value for a quantum mechanical system involves the limit of the weak measurement strength tending to zero. I study how this limit compares to the situation for the undisturbed (no weak measurement) system. Under certain conditions, which I investigate, this limit is discontinuous in the sense that it does not merge smoothly to the Hilbert space description of the undisturbed system. Hence, in these discontinuous cases, the weak value does not represent the undisturbed system. As a result, conclusions drawn from such weak values regarding the properties of the studied system cannot be upheld. Examples are given.
CAPABLE D7.2: AI Ethics and Incidental Findings Policy
Creators: name: Sacchi, Lucia
name: Bottalico, Barbara
name: Lanzola, Giordano
name: Panzarasa, Silvia
name: Parimbelli, Enea
name: Polce, Francesca
name: Quaglini, Silvana
name: Kogan, Alexandra
name: Leizer, Roy
name: Gabetta, Matteo
name: Cornet, Ronald
name: Medlock, Stephanie
name: Barkan, Ella
name: Gilboa-Solomon, Flora
name: Wilk, Szymon
name: Ghio, Viola
name: Tibollo, Valentina
name: Fraterman, Itske
name: Glasspool, David
name: Ottaviano, Manuel
Publisher: name: Zenodo
Year: 2023
Subjects: AI ethics
incidental finding

description: The aim of this deliverable is to describe the approach that the CAPABLE consortium will have with respect to the ethical issues that might arise during the development and use of the CAPABLE AI-based clinical decision support system. In addition, the document also describes the policy related to incidental findings detection and management.
description: This deliverable is a part of a project receiving funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 875052
Mott-hadron resonance gas and lattice QCD thermodynamics
Creators: name: Blaschke, D.
name: Dubinin, A.
name: Turko, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present an effective model for the generic behaviour of hadron masses and phase shifts at finite temperature which shares basic features with recent developments within the PNJL model for correlations in quark matter. On this basis we obtain the transition between a hadron resonance gas phase and the quark gluon plasma in the spirit of the generalized Beth-Uhlenbeck approach where the Mott dissociation of hadrons is encoded in the hadronic phase shifts. Here we restrict ourselves to low-lying hadronic channels and perform a discussion of recent lattice QCD thermodynamics results from this perspective. We find agreement in the asymptotic regions while for the description of the transition itself the inclusion of further hadronic channels as well as a selfconsistent determination of the continuum thresholds is required.
description: 10 pages, 3 figures, typo in Eq. (9) corrected
An Efficient Bayesian Model Selection Approach for Interacting Quantitative Trait Loci Models With Many Effects
Creators: name: Mehta, T.
name: Yi, N.
name: Banerjee, S.
name: Shriner, D.
name: Yandell, B. S.
name: Pomp, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: We extend our Bayesian model selection framework for mapping epistatic QTL in experimental crosses to include environmental effects and gene–environment interactions. We propose a new, fast Markov chain Monte Carlo algorithm to explore the posterior distribution of unknowns. In addition, we take advantage of any prior knowledge about genetic architecture to increase posterior probability on more probable models. These enhancements have significant computational advantages in models with many effects. We illustrate the proposed method by detecting new epistatic and gene–sex interactions for obesity-related traits in two real data sets of mice. Our method has been implemented in the freely available package R/qtlbim (http://www.qtlbim.org) to facilitate the general usage of the Bayesian methodology for genomewide interacting QTL analysis.
Perturbation theory of a superconducting $0-π$ impurity quantum phase transition
Creators: name: Žonda, M.
name: Pokorný, V.
name: Janiš, V.
name: Novotný, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: A single-level quantum dot with Coulomb repulsion attached to two superconducting leads is studied via the perturbation expansion in the interaction strength. We use the Nambu formalism and the standard many-body diagrammatic representation of the impurity Green functions to formulate the Matsubara self-consistent perturbation expansion. We show that at zero temperature second order of the expansion in its $\it{spin-symmetric}$ version yields a nearly perfect agreement with the numerically exact calculations for the position of the $0-π$ phase boundary at which the Andreev bound states reach the Fermi energy as well as for the values of single-particle quantities in the 0-phase. We present results for phase diagrams, level occupation, induced local superconducting gap, Josephson current, and energy of the Andreev bound states with the precision surpassing any (semi)analytical approaches employed thus far.
description: 7 pages, 4 figures; v2: published version, minor updates
ความคาดหวังทางการศึกษาของนักศึกษาบริหารธุรกิจเพื่อการประกอบอาชีพธุรกิจการขนส่งทางอากาศในประเทศไทย ภายใต้สถานการณ์โควิด - 19
Creators: name: ทัศนาวดี ไพโรจน์บริบูรณ์
Publisher: name: ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2565
Subjects: ความคาดหวังทางการศึกษา
ธุรกิจการขนส่งทางอากาศ
โควิด-19
ธุรกิจการบิน
โลจิสติกส์และซัพพลายเชน

description: วารสารครุศาสตร์, 50, 4, EDUCU5004010 (13 pages)
CAPABLE D7.2: AI Ethics and Incidental Findings Policy
Creators: name: Sacchi, Lucia
name: Bottalico, Barbara
name: Lanzola, Giordano
name: Panzarasa, Silvia
name: Parimbelli, Enea
name: Polce, Francesca
name: Quaglini, Silvana
name: Kogan, Alexandra
name: Leizer, Roy
name: Gabetta, Matteo
name: Cornet, Ronald
name: Medlock, Stephanie
name: Barkan, Ella
name: Gilboa-Solomon, Flora
name: Wilk, Szymon
name: Ghio, Viola
name: Tibollo, Valentina
name: Fraterman, Itske
name: Glasspool, David
name: Ottaviano, Manuel
Publisher: name: Zenodo
Year: 2020
Subjects: AI ethics
incidental finding

description: The aim of this deliverable is to describe the approach that the CAPABLE consortium will have with respect to the ethical issues that might arise during the development and use of the CAPABLE AI-based clinical decision support system. In addition, the document also describes the policy related to incidental findings detection and management.
description: This deliverable is a part of a project receiving funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 875052
Thermalization with chemical potentials, and higher spin black holes
Creators: name: Mandal, Gautam
name: Sinha, Ritam
name: Sorokhaibam, Nilakash
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We study the long time behaviour of local observables following a quantum quench in 1+1 dimensional conformal field theories possessing additional conserved charges besides the energy. We show that the expectation value of an arbitrary string of {\it local} observables supported on a finite interval exponentially approaches an equilibrium value. The equilibrium is characterized by a temperature and chemical potentials defined in terms of the quenched state. For an infinite number of commuting conserved charges, the equilibrium ensemble is a generalized Gibbs ensemble (GGE). We compute the thermalization rate in a systematic perturbation in the chemical potentials, using a new technique to sum over an infinite number of Feynman diagrams. The above technique also allows us to compute relaxation times for thermal Green's functions in the presence of an arbitrary number of chemical potentials. In the context of a higher spin (hs[λ]) holography, the partition function of the final equilibrium GGE is known to agree with that of a higher spin black hole. The thermalization rate from the CFT computed in our paper agrees with the quasinormal frequency of a scalar field in this black hole.
description: 22 pages (+ 8 pages of appendix & refs), 4 figures; (v2) references added, notational simplification introduced in equations (63)-(65)
Bayesian Mapping of Genomewide Interacting Quantitative Trait Loci for Ordinal Traits
Creators: name: Pomp, D.
name: Banerjee, S.
name: Yi, N.
name: Yandell, B. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the composite model space approach to complex ordinal traits in experimental crosses. We jointly model main and epistatic effects of QTL and environmental factors on the basis of the ordinal probit model (also called threshold model) that assumes a latent continuous trait underlies the generation of the ordinal phenotypes through a set of unknown thresholds. A data augmentation approach is developed to jointly generate the latent data and the thresholds. The proposed ordinal probit model, combined with the composite model space framework for continuous traits, offers a convenient way for genomewide interacting QTL analysis of ordinal traits. We illustrate the proposed method by detecting new QTL and epistatic effects for an ordinal trait, dead fetuses, in a F2 intercross of mice. Utility and flexibility of the method are also demonstrated using a simulated data set. Our method has been implemented in the freely available package R/qtlbim, which greatly facilitates the general usage of the Bayesian methodology for genomewide interacting QTL analysis for continuous, binary, and ordinal traits in experimental crosses.
Universal formula for the energy--momentum tensor via a flow equation in the Gross--Neveu model
Creators: name: Suzuki, Hiroshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: For the fermion field in the two-dimensional Gross--Neveu model, we introduce a flow equation that allows a simple $1/N$ expansion. By employing the $1/N$ expansion, we examine the validity of a universal formula for the energy--momentum tensor which is based on the small flow-time expansion. We confirm that the formula reproduces a correct normalization and the conservation law of the energy--momentum tensor by computing the translation Ward--Takahashi relation in the leading non-trivial order in the $1/N$ expansion. Also, we confirm that the expectation value at finite temperature correctly reproduces thermodynamic quantities. These observations support the validity of a similar construction of the energy--momentum tensor via the gradient/Wilson flow in lattice gauge theory.
description: 16 pages, 7 figures, the final version to appear in PTEP
กรอบความคิดแบบเติบโต : ทักษะที่จำเป็นแห่งโลกยุคพลิกผัน
Creators: name: ปิยวรรณ วิเศษสุวรรณภูมิ
Publisher: name: ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: โลกยุคพลิกผัน
กรอบความคิดแบบเติบโต
การพัฒนาผู้เรียน
ทักษะที่จำเป็นสำหรับผู้เรียน

description: วารสารครุศาสตร์, 51, 1, EDUCU5101001 (12 pages)
title: The development of an environmental noise decision support system
Creators: name: Galal Abdel-Azim. Ibrahim, Hatem
Publisher: name: University of Liverpool Repository
Year: 2023

description: The methodology of noise control exists to solve many noise problems. The most cost effective methods of controlling noise are those that can employed in advance to prevent any potential noise problem occurring. The majority of architects are overlooking to consider any noise problem during the process of the site planning. This is because the existing methods need long procedure to arrive at the required conclusion regarding the noise performance of the site. The existing methods depend of predicting the noise level at the reception point that effected by the noise source. This depends on many variables, including the distance from source; the propagation effects include screening and ground attenuation ...etc. The second stage comes to establish the kind of the building that the receiver will use. At this stage, the noise control expert can establish the required noise performance to solve the problem. Another complicated procedure comes by using the methodology of the noise control, which branches to many options. The chosen option depends on a certain priority and the condition of the architect. On the basis of the above, the thesis concerns with developing another method using the existing techniques, but to use by the architects or the novice users. This method gives the prediction of the noise level at the reception point, establishing the required noise performance and finally gives the suitable advice to solve the problem. The Artificial Intelligence (AI) techniques in general and Expert System (ES) in particular have been employed to develop this method. The most important part in this technique is the knowledge base that will be used to fulfil the desired objective This knowledge has to proceed within many stages, which called knowledge acquisition process. This process consists of 5 main stages, which concerns with identifying the objectives of the system with drawing a relationship between the different factors that effect the desired conclusion. This knowledge should be taken to establish the main concept that will be used to be represented in an expert system. The next stage comes to formalise the collected knowledge followed by the implementation stage and finally the evaluation of the system.
Distribution of phonon lifetime in Brillouin zone
Creators: name: Togo, Atsushi
name: Chaput, Laurent
name: Tanaka, Isao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Lattice thermal conductivities of zincblende- and wurtzite-type compounds with 33 combinations of elements are calculated with the single-mode relaxation-time approximation and linearized phonon Boltzmann equation from first-principles anharmonic lattice dynamics calculations. In 9 zincblende-type compounds, distributions of phonon linewidths (inverse phonon lifetimes) are discussed in detail. The phonon linewidths vary non-smoothly with respect to wave vector, which is explained from the imaginary parts of the self energies. It is presented that detailed combination of phonon-phonon interaction strength and three phonon selection rule is critically important to determine phonon lifetime for these compounds. This indicates difficulty to predict phonon lifetime quantitatively without anharmonic force constants. However it is shown that joint density of states weighted by phonon numbers, which is calculated only from harmonic force constants, can be potentially used for a screening of the lattice thermal conductivity of materials.
Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome
Creators: name: Threadgill, D. W.
name: Zou, F.
name: Eversley, C. D.
name: Huang, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.
Experimental Estimate of the Abundance and Effects of Nearly Neutral Mutations in the RNA Virus ϕ6
Creators: name: Burch, Christina L.
name: Samarov, Daniel
name: Shen, Haipeng
name: Guyader, Sebastien
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Although the frequency and effects of neutral and nearly neutral mutations are critical to evolutionary patterns and processes governed by genetic drift, the small effects of such mutations make them difficult to study empirically. Here we present the results of a mutation-accumulation experiment designed to assess the frequencies of deleterious mutations with undetectable effects. We promoted the accumulation of spontaneous mutations by subjecting independent lineages of the RNA virus φ6 to repeated population bottlenecks of a single individual. We measured fitness following every bottleneck to obtain a complete picture of the timing and effects of the accumulated mutations with detectable effects and sequenced complete genomes to determine the number of mutations that were undetected by the fitness assays. To estimate the effects of the undetected mutations, we implemented a likelihood model developed for quantitative trait locus (QTL) data (Otto and Jones 2000) to estimate the number and effects of the undetected mutations from the measured number and effects of the detected mutations. Using this method we estimated a deleterious mutation rate of U = 0.03 and a gamma effects distribution with mean and coefficient of variation = 0.204. Although our estimates of U and fall within the range of recent mutation rate and effect estimates in eukaryotes, the fraction of mutations with detectable effects on laboratory fitness (39%) appears to be far higher in φ6 than in eukaryotes.
Search for pair-produced long-lived neutral particles decaying in the ATLAS hadronic calorimeter in $pp$ collisions at $\sqrt{s}$ = 8 TeV
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3 fb$^{-1}$ of data collected in proton--proton collisions at $\sqrt{s}$ = 8 TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeV to 900 GeV, and a long-lived neutral particle mass from 10 GeV to 150 GeV.
description: 10 pages plus author list + cover pages (22 pages total), 6 figures, 4 tables, submitted to Physics Letters B, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2012-28
Effects of low energy availability and high-impact exercise on physiological markers of bone and vascular health
Creators: name: Hutson, Mark
Publisher: name: Loughborough University
Year: 2023
Subjects: Sports science and exercise not elsewhere classified

description: Athletes often expend large amounts of energy during exercise and some, particularly endurance-based athletes, are under pressure to maintain a low body weight. This places many athletes at risk of low energy availability (LEA), which has been associated with impaired bone health, menstrual function, and vascular function in female athletes and exercisers. There is a clear gap in the literature regarding non-pharmaceutical therapeutic interventions to protect bone health in females at risk of LEA. A review of the existing literature (Chapter 4) identified structural bone decrements that are consistent across studies in female athletes with long-term LEA. It was also shown in Chapter 4 that high-impact exercise interventions can improve bone structure in an energy efficient manner, but there was no research regarding the effects of high-impact exercise during LEA in young healthy populations. This was explored in Chapters 5 and 7. Performing a brief high-impact jumping intervention twice daily mitigated the effects of three days of LEA on bone resorption, but not formation, in active, regularly menstruating young females (Chapter 7). Bone stress injury incidence was elevated in competitive female distance runners reporting <9 menses over the previous 12 months (indicative of LEA), but only in those that did not regularly participate in high-impact plyometric style training (Chapter 5). The effects of LEA on vascular function have only been investigated in cross-sectional studies, which compared females with amenorrhoea (secondary to LEA) to healthy counterparts. The effects of LEA per se, independent of estrogen deficiency, cannot be elucidated using this model and it is unclear when vascular effects begin to manifest. It was shown in Chapter 8 that resting regional blood flow was supressed during three days of LEA, and blood flow recovery from peak to resting during reactive hyperaemia was slowed, in active, regularly menstruating young females. Participants were estrogen replete and estrogen concentrations remained stable during LEA. In conclusion, findings from Chapters 4, 5 and 7 show that short and long-term LEA exerts negative effects on bone and should be avoided. If bouts of LEA are unavoidable, high-impact jumping exercise can help to mitigate some of the negative effects on bone and may minimise the risk of bone stress injury. However, controlled prospective research is needed to investigate the benefits of high-impact exercise during longer-term LEA. Vascular effects of LEA manifest far more quickly than previously known, and independent of estrogen deficiency. This may limit exercise performance and recovery in active females that regularly experience bouts of LEA and could increase the risk of cardiovascular health complications.
Cosmological perturbations in mimetic matter model
Creators: name: Matsumoto, Jiro
name: Odintsov, Sergei D.
name: Sushkov, Sergey V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the cosmological evolution of mimetic matter model with arbitrary scalar potential. The cosmological reconstruction, which is the way to construct a model for arbitrary evolutions of the scale factor, is explicitly done for different choices of potential. The cases that mimetic matter model shows the evolution as Cold Dark Matter(CDM), wCDM model, dark matter and dark energy with dynamical $Om(z)$, where $Om(z) \equiv [ (H(z)/H_0)^2-1 ]/[(1+z)^3 -1],$ or phantom dark energy with phantom-non-phantom crossing are presented in detail. The cosmological perturbations for such evolution are studied in mimetic matter model. For instance, the evolution behavior of the matter density contrast which is different from usual one, i.e. $\ddot δ+ 2 H \dot δ- κ^2 ρδ/2 = 0$ is investigated. The possibility of peculiar evolution of $δ$ in the model under consideration is shown. Special attention is paid to the behavior of matter density contrast near to future singularity where decay of perturbations may occur much earlier the singularity.
description: 20 pages, 7 figures, version to appear in PRD
Heteroduplex DNA in Meiotic Recombination in Drosophila mei-9 Mutants
Creators: name: Radford, Sarah J.
name: Blanton, Hunter L.
name: Sekelsky, Jeff
name: McMahan, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Meiotic recombination gives rise to crossovers, which are required in most organisms for the faithful segregation of homologous chromosomes during meiotic cell division. Characterization of crossover-defective mutants has contributed much to our understanding of the molecular mechanism of crossover formation. We report here a molecular analysis of recombination in a Drosophila melanogaster crossover-defective mutant, mei-9. In the absence of mei-9 activity, postmeiotic segregation associated with noncrossovers occurs at the expense of crossover products, suggesting that the underlying meiotic function for MEI-9 is in crossover formation rather than mismatch repair. In support of this, analysis of the arrangement of heteroduplex DNA in the postmeiotic segregation products reveals different patterns from those observed in Drosophila Msh6 mutants, which are mismatch-repair defective. This analysis also provides evidence that the double-strand break repair model applies to meiotic recombination in Drosophila. Our results support a model in which MEI-9 nicks Holliday junctions to generate crossovers during meiotic recombination, and, in the absence of MEI-9 activity, the double Holliday junction intermediate instead undergoes dissolution to generate noncrossover products in which heteroduplex is unrepaired.
สุขภาพจิตโรงเรียน : แนวทางการส่งเสริมสุขภาพจิตวัยรุ่น
Creators: name: นันทกา สุปรียาพร
Publisher: name: ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: สุขภาพจิตโรงเรียน
แนวทางการส่งเสริมสุขภาพจิต
สุขภาพจิตวัยรุ่น
โรงเรียนเป็นฐาน
ความรอบรู้ด้านสุขภาพจิต

description: วารสารครุศาสตร์, 51, 1, EDUCU5101002 (13 pages)
Meiotic Recombination in Drosophila Msh6 Mutants Yields Discontinuous Gene Conversion Tracts
Creators: name: Radford, Sarah J.
name: Sekelsky, Jeff
name: McMahan, Susan
name: Sabourin, Mathilde M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination intermediates. Heterologies in hDNA are usually repaired prior to the recovery of recombination products, thereby obscuring information about the arrangement of hDNA. To examine hDNA in meiotic recombination in Drosophila melanogaster, we sought to block hDNA repair by conducting recombination assays in a mutant defective in mismatch repair (MMR). We generated mutations in the MMR gene Msh6 and analyzed recombination between highly polymorphic homologous chromosomes. We found that hDNA often goes unrepaired during meiotic recombination in an Msh6 mutant, leading to high levels of postmeiotic segregation; however, hDNA and gene conversion tracts are frequently discontinuous, with multiple transitions between gene conversion, restoration, and unrepaired hDNA. We suggest that these discontinuities reflect the activity of a short-patch repair system that operates when canonical MMR is defective.
Role of measurement-feedback separation in autonomous Maxwell's demons
Creators: name: Shiraishi, Naoto
name: Ito, Sosuke
name: Kawaguchi, Kyogo
name: Sagawa, Takahiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We introduce an information heat engine that is autonomous (i.e., without any time-dependent parameter) but has separated measurement and feedback processes. This model serves as a bridge between the other types of information heat engines inspired by Maxwell's demon; from the original Szilard-engine type systems to the autonomous demonic setups. By analyzing our model on the basis of a general framework introduced in our previous paper [N. Shiraishi and T. Sagawa, Phys. Rev. E {\bf 91}, 012130 (2015).], we clarify the role of the separation of measurement and feedback in the integral fluctuation theorems.
description: 16 pages, 9 figures
title: The Cerenkov free electron laser
Creators: name: Petichakis, Christos.
Publisher: name: University of Liverpool Repository
Year: 2023

description: This thesis reports on an investigation into Cerenkov Free Electron Lasers. These devices are basically travelling wave tubes but having a dielectrically lined cylinder as the slow wave structure rather than a helix. If an electron beam is injected into the centre of this structure, an interaction between the electrons and the electromagnetic (e-m) TMo I mode can occur which can lead to amplification of the e-m wave. Two different systems have been constructed. The first one was designed to operate as an oscillator at 12.4GHz and used a rectangular X-band waveguide microwave coupler. It was thought that the non-operation of this device could have been due to a lack of net gain, and so a second system was designed having a smaller diameter dielectric liner in order to achieve higher gain but at a slightly higher frequency of operation (l6.9GHz). In both systems, the interception of the electron beam with the dielectric liner was small. Unfortunately, even though a maximum electron beam current of 120mA was achieved, leading to an expected small signal gain of 1200%, no microwave output was observed either. At this stage it was considered that there must he something more fundamental at fault with these systems. After a thorough investigation. it was discovered that the small gap which always exists between the dielectric liner and the waveguide affected the dispersion relation of a Cerenkov system. Theoretically, gaps as small as 1 % of the diameter of the waveguide were found to have a serious effect, and although these gaps would not stop the operation of the Cerenkov device, microwave output would only be expected at a voltage far from that expected. It was found that the problem could be overcome by coating the outer surface of the dielectric tube with a layer of conducting material, such as silver paint, which effectively removes the gap. Further tests of a Cerenkov free electron laser with this improvement are in progress.
Multiple Functions of Drosophila BLM Helicase in Maintenance of Genome Stability
Creators: name: McVey, M.
name: Andersen, S. L.
name: Sekelsky, J.
name: Broze, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Bloom Syndrome, a rare human disorder characterized by genomic instability and predisposition to cancer, is caused by mutation of BLM, which encodes a RecQ-family DNA helicase. The Drosophila melanogaster ortholog of BLM, DmBlm, is encoded by mus309. Mutations in mus309 cause hypersensitivity to DNA-damaging agents, female sterility, and defects in repairing double-strand breaks (DSBs). To better understand these phenotypes, we isolated novel mus309 alleles. Mutations that delete the N terminus of DmBlm, but not the helicase domain, have DSB repair defects as severe as those caused by null mutations. We found that female sterility is due to a requirement for DmBlm in early embryonic cell cycles; embryos lacking maternally derived DmBlm have anaphase bridges and other mitotic defects. These defects were less severe for the N-terminal deletion alleles, so we used one of these mutations to assay meiotic recombination. Crossovers were decreased to about half the normal rate, and the remaining crossovers were evenly distributed along the chromosome. We also found that spontaneous mitotic crossovers are increased by several orders of magnitude in mus309 mutants. These results demonstrate that DmBlm functions in multiple cellular contexts to promote genome stability.
Dünnfilmtransistoren mit halbleitenden Nanopartikeln: Integrationstechniken für Einzelbauelemente und komplementäre Schaltungen auf flexiblen Substraten
Creators: name: Reker, Julia
Publisher: name: Universität Paderborn
Year: 2023

description: Unter dem Ausdruck flexible Elektronik werden leichte, biegbare und mitunter transparente Schaltungen zusammengefasst. Die grundlegenden Bausteine dieser Technologiesind Dünnfilmtransistoren (TFTs), die den Stromfluss in elektronischen Schaltungen steuern. Dieser Technologiezweig soll keine Konkurrenz zur konventionellen siliziumbasierten Elektronik darstellen, sondern durch die Kombination beider Technologien neuartige Anwendungen ermöglichen. Die in dieser Arbeit entwickelten TFTs für die flexible Elektronik basieren auf anorganischen Halbleitern. Für einen verlustarmen Betrieb sind Schaltungen in Komplementärtechnik erforderlich. Während der Großteil an Metalloxiden n-leitendes Verhalten aufweisen, ist die Auswahl an intrinsischen p-Halbleitern jedoch begrenzt. Ein p-leitendes Material ist CuO, das in dieser Arbeit untersucht wurde. Für die n-Typ-TFTs wurde ZnO verwendet, das als Halbleiter in der flexiblen Elektronik bereits weit verbreitet ist. Im Hinblick auf eine kostengünstige Integration, die zudem kompatibel mit einer großflächigen Herstellung auf flexiblen Substraten sein soll, wurde in dieser Arbeit die Verwendung lösungsmittelbasierter Prozesse forciert.
description: The expression flexible electronics is used to describe lightweight, bendable and sometimes transparent circuits. The basic building blocks of this technology are thin-filmtransistors (TFTs), which control the current flow in electronic circuits. This branch oftechnology is not intended to compete with conventional silicon-based electronics, but toenable novel applications by combining both technologies.The TFTs developed in this work are based on inorganic semiconductors. Complementary technology circuits are required for low-loss operation. However, while the majority of metal oxides exhibit n-type behavior, the choice of intrinsic p-type semiconductors is limited. Such a p-type material is CuO, which will be investigated in this work. For the n-typeTFTs, ZnO is used, which is already widely applied as a semiconductor in flexible electronics. With regard to low-cost integration, which should also be compatible with large-area fabrication on flexible substrates, this work enforces the use of solvent-based processes.
Ninety-Six Haploid Yeast Strains With Individual Disruptions of Open Reading Frames Between YOR097C and YOR192C, Constructed for the Saccharomyces Genome Deletion Project, Have an Additional Mutation in the Mismatch Repair Gene MSH3
Creators: name: Petes, T. D.
name: Stone, M. M.
name: Farber, R. A.
name: Lehner, K. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: As part of the Saccharomyces Genome Deletion Project, sets of presumably isogenic haploid and diploid strains that differed only by single gene deletions were constructed. We found that one set of 96 strains (containing deletions of ORFs located between YOR097C and YOR192C) in the collection, which was derived from the haploid BY4741, has an additional mutation in the MSH3 mismatch repair gene.
เครื่องมืออนาคตวิทยาการศึกษาเพื่อส่งเสริมทักษะการเรียนรู้ตลอดชีวิตของพลเมืองเน็กซ์ในยุคชีวิตปกติวิถีถัดไป
Creators: name: วสุธาร พันธุ์อร่าม
Publisher: name: ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: อนาคตวิทยาการศึกษา
ทักษะการเรียนรู้ตลอดชีวิต
พลเมืองเน็กซ์

description: วารสารครุศาสตร์, 51, 1, EDUCU5101003 (13 pages)
Reducing DNA Polymerase   in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects
Creators: name: Hussain, S. K.
name: Sekelsky, J.
name: LaRocque, J. R.
name: Dougherty, D. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and replication checkpoint responses. In Drosophila, the ATR ortholog (MEI-41) is essential for preventing entry into mitosis in the presence of DNA damage. In the absence of MEI-41, heterozygosity for the E(mus304) mutation causes rough eyes. We found that E(mus304) is a mutation in DNApol-α180, which encodes the catalytic subunit of DNA polymerase α. We did not find any defects resulting from reducing Polα by itself. However, reducing Polα in the absence of MEI-41 resulted in elevated P53-dependent apoptosis, rough eyes, and increased genomic instability. Reducing Polα in mutants that lack downstream components of the DNA damage checkpoint (DmChk1 and DmChk2) results in the same defects. Furthermore, reducing levels of mitotic cyclins rescues both phenotypes. We suggest that reducing Polα slows replication, imposing an essential requirement for the MEI-41-dependent checkpoint for maintenance of genome stability, cell survival, and proper development. This work demonstrates a critical contribution of the checkpoint function of MEI-41 in responding to endogenous damage.
Synthetic Lethality of Drosophila in the Absence of the MUS81 Endonuclease and the DmBlm Helicase Is Associated With Elevated Apoptosis
Creators: name: Brill, S. J.
name: Trowbridge, K.
name: McKim, K.
name: Sekelsky, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Mus81-Mms4 (Mus81-Eme1 in some species) is a heterodimeric DNA structure-specific endonuclease that has been implicated in meiotic recombination and processing of damaged replication forks in fungi. We generated and characterized mutations in Drosophila melanogaster mus81 and mms4. Unlike the case in fungi, we did not find any role for MUS81-MMS4 in meiotic crossing over. A possible role for this endonuclease in repairing double-strand breaks that arise during DNA replication is suggested by the finding that mus81 and mms4 mutants are hypersensitive to camptothecin; however, these mutants are not hypersensitive to other agents that generate lesions that slow or block DNA replication. In fungi, mus81, mms4, and eme1 mutations are synthetically lethal with mutations in genes encoding RecQ helicase homologs. Similarly, we found that mutations in Drosophila mus81 and mms4 are synthetically lethal with null mutations in mus309, which encodes the ortholog of the Bloom Syndrome helicase. Synthetic lethality is associated with high levels of apoptosis in proliferating tissues. Lethality and elevated apoptosis were partially suppressed by a mutation in spn-A, which encodes the ortholog of the strand invasion protein Rad51. These findings provide insights into the causes of synthetic lethality.
A blind CO detection of a Distant Red Galaxy in the HS1700+64 proto-cluster
Creators: name: Chapman, S. C.
name: Bertoldi, F.
name: Smail, Ian
name: Blain, A. W.
name: Geach, J. E.
name: Gurwell, M.
name: Ivison, R. J.
name: Petitpas, G. R.
name: Reddy, N.
name: Steidel, C. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the blind detection of 12CO emission from a Distant Red Galaxy, HS1700.DRG55. We have used the IRAM PdBI-WIDEX, with its 3.6GHz of instantaneous dual-polarization bandwidth, to target 12CO(3--2) from galaxies lying in the proto-cluster at z=2.300 in the field HS1700+64. If indeed this line in DRG55 is 12CO(3--2), it's detection at 104.9GHz indicates a z_CO=2.296. None of the other eight known z~2.30 proto-cluster galaxies lying within the primary beam (PB) are detected in 12CO, although the limits are ~2x worse towards the edge of the PB where several lie. The optical/near-IR magnitudes of DRG55 (R_AB>27, K_AB=22.3) mean that optical spectroscopic redshifts are difficult with 10m-class telescopes, but near-IR redshifts would be feasible. The 24um-implied SFR (210 M_odot yr-1), stellar mass (~10^11 M-odot) and 12CO line luminosity (3.6x10^10 K km s-1 pc^2) are comparable to other normal 12CO-detected star forming galaxies in the literature, although the galaxy is some ~2 mag (~6x) fainter in the rest-frame UV than 12CO-detected galaxies at z>2. The detection of DRG55 in 12CO complements three other 12CO detected UV-bright galaxies in this proto-cluster from previous studies, and suggests that many optically faint galaxies in the proto-cluster may host substantial molecular gas reservoirs, and a full blind census of 12CO in this overdense environment is warranted.
description: 5 pages, matching the proof version in MNRAS
The Caenorhabditis elegans Rad17 Homolog HPR-17 Is Required for Telomere Replication
Creators: name: Walker, Dana
name: Boerckel, Julie
name: Ahmed, Shawn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.
Definition of SIPM requirements and performance studies with simulations of different use cases
Creators: name: R. Pestotnik
Publisher: name: Zenodo
Year: 2023
Subjects: WP8

description: This report details the requirements of the photodetectors for the investigation of neutron resistant SiPM technology within the framework of the AIDAinnova programme. We discuss the recent different use cases, where the single photosensors are required. Finally, we give an overview of the performance simulations of application of such highly efficient sensors in the real environment.
End Joining at Caenorhabditis elegans Telomeres
Creators: name: Lowden, M. R.
name: Hall, J.
name: Ahmed, S.
name: Meier, B.
name: Lee, T. W.-s.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage–fusion–bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Current models for the molecular basis of fusion of critically shortened, uncapped telomeres rely on PCR assays that typically capture fusion breakpoints created by direct ligation of chromosome ends. Here we use independent approaches that rely on distinctive features of Caenorhabditis elegans to study the frequency of direct end-to-end chromosome fusion in telomerase mutants: (1) holocentric chromosomes that allow for genetic isolation of stable end-to-end fusions and (2) unique subtelomeric sequences that allow for thorough PCR analysis of samples of genomic DNA harboring multiple end-to-end fusions. Surprisingly, only a minority of end-to-end fusion events resulted from direct end joining with no additional genome rearrangements. We also demonstrate that deficiency for the C. elegans Ku DNA repair heterodimer does not affect telomere length or cause synthetic effects in the absence of telomerase.
CAPABLE D7.6: Informed Patient Consent/Assent Form, Ethical Committee Approval, Training Materials, and Technical Manual for Maintenance
Creators: name: Quaglini, Silvana
name: Sacchi, Lucia
name: Peleg, Mor
name: Tibollo, Valentina
Publisher: name: Zenodo
Year: 2022
Subjects: pilot study
study authorization
training plan
software maintenance

description: In this deliverable, we present the activities carried out in WP7 in preparation for the CAPABLE pilot studies. These activities include: the preparation of the preliminary documentation for study authorization in compliance to the current EU regulations in terms of data protection and medical devices usage, the preparation of a training plan for the users of the system and for the technical staff who will support users during the study, and the definition of the policies for the maintenance of the CAPABLE software and of the devices that are needed for it to be used. This document is organized into three Sections, each one related to the described activities. Being this a Demonstration deliverable, it includes the references to all the documentation that has been prepared during the last year of the project. The links to the available documentation are reported in the Annexes Section.
description: This deliverable is a part of a project receiving funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 875052
$G^{k,l}$-constrained multi-degree reduction of Bézier curves
Creators: name: Gospodarczyk, Przemysław
name: Lewanowicz, Stanisław
name: Woźny, Paweł
Publisher: name: arXiv
Year: 2015
Subjects: subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: We present a new approach to the problem of $G^{k,l}$-constrained ($k,l \leq 3$) multi-degree reduction of Bézier curves with respect to the least squares norm. First, to minimize the least squares error, we consider two methods of determining the values of geometric continuity parameters. One of them is based on quadratic and nonlinear programming, while the other uses some simplifying assumptions and solves a system of linear equations. Next, for prescribed values of these parameters, we obtain control points of the multi-degree reduced curve, using the properties of constrained dual Bernstein basis polynomials. Assuming that the input and output curves are of degree $n$ and $m$, respectively, we determine these points with the complexity $O(mn)$, which is significantly less than the cost of other known methods. Finally, we give several examples to demonstrate the effectiveness of our algorithms.