title: Ð¡Ð¸Ð³Ð½Ð°Ð»ÑÐ½ÑÐµ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ CD68 Ð¸ TIMP-1 ÐºÐ°Ðº Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÐµ Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑÑ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð° Ð¸ ÑÐ°ÑÐºÐ¾Ð¸Ð´Ð¾Ð·Ð° Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð´ÑÑ Ð°Ð½Ð¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: CD68 and TIMP-1 signaling molecules as differential biomarkers of respiratory organs tuberculosis and sarcoidosis
Creators: name: ÐÑÐºÐ¾Ð²Ð°, ÐÑÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐºÐ»Ð°ÑÑÐµÑ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÐ¾Ð²ÐºÐ¸ 68
ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð¹ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ñ Ð¼Ð°ÑÑÐ¸ÐºÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð·-1
ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·
ÑÐ°ÑÐºÐ¾Ð¸Ð´Ð¾Ð·
Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ñ
ÑÐ¸Ð±ÑÐ¾Ð·
Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾Ñ Ð¸Ð¼Ð¸Ñ
Ð¸Ð¼Ð¼ÑÐ½Ð¾ÑÐ¸ÑÐ¾Ñ Ð¸Ð¼Ð¸Ñ
Ð±ÑÐºÐºÐ°Ð»ÑÐ½ÑÐ¹ ÑÐ¿Ð¸ÑÐµÐ»Ð¸Ð¹
Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð°Ñ Ð½ÐµÐ¸Ð½Ð²Ð°Ð·Ð¸Ð²Ð½Ð°Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ°
cluster designation 68
tissue inhibitor of matrix metalloproteinases-1
tuberculosis
sarcoidosis
inflammation
reparation
fibrosis
immunohistochemistry
immunocytochemistry
buccal epithelium
differential non-invasive diagnostics

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿Ð¾Ð¸ÑÐºÑ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð±Ð¸Ð¾Ð¼Ð¾Ð»ÐµÐºÑÐ» Ð´Ð»Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¸ Ð½ÐµÐ¸Ð½Ð²Ð°Ð·Ð¸Ð²Ð½Ð¾Ð¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð° Ð¸ ÑÐ°ÑÐºÐ¾Ð¸Ð´Ð¾Ð·Ð° Ð»ÐµÐ³ÐºÐ¸Ñ. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¾ÑÐµÐ½ÐµÐ½Ñ ÑÑÐ¾Ð²Ð½Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð² CD68 Ð¸ TIMP-1 Ð² Ð»ÐµÐ³Ð¾ÑÐ½ÑÑ ÑÐºÐ°Ð½ÑÑ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð². Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð° Ð´Ð»Ñ Ð½ÐµÐ¸Ð½Ð²Ð°Ð·Ð¸Ð²Ð½Ð¾Ð¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ ÐºÐ»ÐµÑÐºÐ¸ Ð±ÑÐºÐºÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¿Ð¸ÑÐµÐ»Ð¸Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð². Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð´Ð°Ð½Ð½ÑÑ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð¾ÐºÑÐ°ÑÐ¸Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð², Ð±ÑÐ»Ð¾ Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÑÐºÐ°Ð½ÐµÐ²ÑÑ ÑÑÐ¾Ð²Ð½ÐµÐ¹ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ CD68 Ð¸ TIMP-1 Ð¿ÑÐ¸ ÑÐ°ÑÐºÐ¾Ð¸Ð´Ð¾Ð·Ðµ Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ ÑÐ°ÐºÐ¾Ð²ÑÐ¼Ð¸ Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ, ÑÑÐ¾ Ð´ÐµÐ»Ð°ÐµÑ Ð¸Ñ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½ÑÐ¼Ð¸ Ð¼Ð°ÑÐºÐµÑÐ°Ð¼Ð¸ Ð´Ð»Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸. ÐÐ¾Ð¼Ð¸Ð¼Ð¾ ÑÑÐ¾Ð³Ð¾, Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ Ð² Ð»ÐµÐ³ÐºÐ¸Ñ Ð¾ÑÐ¼ÐµÑÐ°ÐµÑÑÑ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð¾Ð±Ð¾Ð¸Ñ Ð¼Ð°ÑÐºÐµÑÐ¾Ð² Ð¿Ð¾ Ð¼ÐµÑÐµ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð¸ ÑÐºÐ°Ð½Ð¸, ÑÑÐ¾ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÐµÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ Ð´Ð°Ð½Ð½ÑÐµ Ð±ÐµÐ»ÐºÐ¸ Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð¿ÑÐ¾Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð¾Ð¼. Ð¢Ð°ÐºÐ¶Ðµ Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ Ð»ÐµÐ³ÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ TIMP-1 Ð² ÐºÐ»ÐµÑÐºÐ°Ñ Ð±ÑÐºÐºÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¿Ð¸ÑÐµÐ»Ð¸Ñ ÐºÐ¾ÑÑÐµÐ»Ð¸ÑÑÑÑ Ñ ÐµÐ³Ð¾ ÑÑÐ¾Ð²Ð½ÑÐ¼Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð² Ð»ÐµÐ³Ð¾ÑÐ½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸. Ð¡Ð°ÑÐºÐ¾Ð¸Ð´Ð¾Ð· Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð´ÑÑÐ°Ð½Ð¸Ñ Ð½Ðµ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´Ð°Ð»ÑÑ ÑÐºÑÐ¿ÑÐµÑÑÐ¸ÐµÐ¹ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð±ÐµÐ»ÐºÐ° Ð² Ð±ÑÐºÐºÐ°Ð»ÑÐ½Ð¾Ð¼ ÑÐ¿Ð¸ÑÐµÐ»Ð¸Ð¸, Ð² ÑÐ²ÑÐ·Ð¸ Ñ ÑÐµÐ¼ ÑÐ´ÐµÐ»Ð°Ð½ Ð²ÑÐ²Ð¾Ð´, ÑÑÐ¾ TIMP-1 Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð²ÐºÐ»ÑÑÐµÐ½ Ð² Ð¿Ð°Ð½ÐµÐ»Ñ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ Ð¼Ð°ÑÐºÐµÑÐ¾Ð² Ð´Ð»Ñ Ð½ÐµÐ¸Ð½Ð²Ð°Ð·Ð¸Ð²Ð½Ð¾Ð¹ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°.
description: This work is devoted to the search for signaling biomolecules for differential and non-invasive diagnostics of pulmonary tuberculosis and sarcoidosis. The expression levels of proteins CD68 and TIMP-1 in lung tissues of patients were evaluated in this work. The buccal epithelium cells of patients were used as a promising material for non-invasive diagnostics. An increase in tissue levels of CD68 and TIMP-1 expression was registered in sarcoidosis compared to those in tuberculosis as a result of statistical analysis of the data obtained during specimens immunostaining, which makes them informative markers for differential diagnosis. Furthermore, an increase of expression of both markers is observed in pulmonary tuberculosis along with the processes of tissue repair, which indicates that these proteins have prognostic potential. The study also demonstrated that TIMP-1 expression levels in buccal epithelium cells correlate with its expression levels in lung tissue in cases of pulmonary tuberculosis. Respiratory sarcoidosis is not accompanied by this protein expression in buccal epithelium, hence it was concluded that TIMP-1 can be included in the panel of molecular markers for non-invasive differential diagnostics of tuberculosis.