cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Positioning pharmacists’ roles in primary health care: a discourse analysis of the compensation plan in Alberta, Canada
Creators: name: Hughes, Christine A
name: Breault, Rene R
name: Hicks, Deborah
name: Schindel, Theresa J
Publisher: name: BioMed Central
Year: 2018

description: Background: A comprehensive Compensation Plan for pharmacy services delivered by community pharmacists was implemented in Alberta, Canada in July 2012. Services covered by the Compensation Plan include care planning services, prescribing services such as adapting prescriptions, and administering a drug or publicly-funded vaccine by injection. Understanding how the Compensation Plan was framed and communicated provides insight into the roles of pharmacists and the potential influence of language on the implementation of services covered by the Compensation Plan by Albertan pharmacists. The objective of this study is to examine the positioning of pharmacists’ roles in documents used to communicate the Compensation Plan to Albertan pharmacists and other audiences. Methods: Publicly available documents related to the Compensation Plan, such as news releases or reports, published between January 2012 and December 2015 were obtained from websites such as the Government of Alberta, Alberta Blue Cross, the Alberta College of Pharmacists, the Alberta Pharmacists’ Association, and the Blueprint for Pharmacy. Searches of the Canadian Newsstand database and Google identified additional documents. Discourse analysis was performed using social positioning theory to explore how pharmacists’ roles were constructed in communications about the Compensation Plan. Results: In total, 65 publicly available documents were included in the analysis. The Compensation Plan was put forward as a framework for payment for professional services and formal legitimization of pharmacists’ changing professional roles. The discourse associated with the Compensation Plan positioned pharmacists’ roles as: (1) expanding to include services such as medication management for chronic diseases, (2) contributing to primary health care by providing access to services such as prescription renewals and immunizations, and (3) collaborating with other health care team members. Pharmacists’ changing roles were positioned in alignment with the aims of primary health care. Conclusions: Social positioning theory provides a useful lens to examine the dynamic and evolving roles of pharmacists. This study provides insight into how communications regarding the Compensation Plan in Alberta, Canada positioned pharmacists’ changing roles in the broader context of changes to primary health care delivery. Our findings may be useful for other jurisdictions considering implementation of remunerated clinical services provided by pharmacists.
title: Treatment of Tungiasis with Dimeticone
title: A Proof-of-Principle Study in Rural Kenya
titleType: Subtitle
Creators: name: Thielecke, Marlene
name: Nordin, Per
name: Ngomi, Nicholas
name: Feldmeier, Hermann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Tungiasis (sand flea disease) is a neglected tropical disease, prevalent in resource-poor communities in South America and sub-Saharan Africa. It is caused by an inflammatory response against penetrated female sand fleas (Tunga penetrans) embedded in the skin of the host. Although associated with debilitating acute and chronic morbidity, there is no proven effective drug treatment. By consequence patients attempt to remove embedded sand fleas with non-sterile sharp instruments, such as safety pins, a procedure that represents a health threat by itself. In this proof-of-principle study we compared the topical application of a mixture of two dimeticones of low viscosity (NYDA) to the topical application of a 0.05% solution of KMnO4 in 47 school children in an endemic area in rural Kenya. The efficacy of the treatment was assessed during a follow up period of seven days using viability signs of the embedded parasites, alterations in the natural development of lesion morphology and the degree of local inflammation as outcome measures. Seven days after treatment, in the dimeticone group 78% (95% CI 67–86%) of the parasites had lost all signs of viability as compared to 39% (95% CI 28–52%) in the KMnO4 group (p<0.001). In the dimeticone group 90% (95% CI 80–95%) of the penetrated sand fleas showed an abnormal development already after 5 days, compared to 53% (95% CI 40–66%; p<0.001) in the KMnO4 group. Seven days after treatment, signs of local skin inflammation had significantly decreased in the dimeticone group (p<0.001). This study identified the topical application of dimeticones of low viscosity (NYDA) as an effective means to kill embedded sand fleas. In view of the efficacy and safety of the topical treatment with dimeticone, the mechanical extraction of embedded sand fleas using hazardous instruments is no longer warranted.
Celebrating 75 years of theTelecommunications Journal of Australia: Reflecting 75 years of innovation and change in the Australian telecommunications industry
Creators: name: Gerrand, Peter
Publisher: name: Swinburne
Year: 2024

description: The 75 years of innovation and change in the Australian telecommunications industry is discussed. The tradition of encouraging contributions during office hours to the TJA's Board of Editors continued when the telecommunications arm of the PMG became Telecom Australia in 1975, right up until 1991. the changing contents of TJA reflect the evolution of the Australian telecommunications industry from its beginnings in the PMG era (when telecommunications was regarded as too important for the growth of the new nation to be left to the private sector) to the1990s (when telecommunications was regarded as too important for the economy to be left to government) and beyond. This means that TJA remains heavily dependent on the civic-mindedness of experts, both in industry as well as in the universities, who are motivated to publish their ideas and recommendations to a broader audience, and especially to the decision makers who are influential in framing new regulatory legislation.
Specific DTI seeding and diffusivity-analysis improve the quality and prognostic value of TMS-based deterministic DTI of the pyramidal tract
Creators: name: Rosenstock, Tizian
name: Giampiccolo, Davide
name: Schneider, Heike
name: Runge, Sophia Jutta
name: Baehrend, Ina
name: Vajkoczy, Peter
name: Picht, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Object Navigated transcranial magnetic stimulation (nTMS) combined with diffusion tensor imaging (DTI) is used preoperatively in patients with eloquent-located brain lesions and allows analyzing non-invasively the spatial relationship between the tumor and functional areas (e.g. the motor cortex and the corticospinal tract [CST]). In this study, we examined the diffusion parameters FA (fractional anisotropy) and ADC (apparent diffusion coefficient) within the CST in different locations and analyzed their interrater reliability and usefulness for predicting the patients' motor outcome with a precise approach of specific region of interest (ROI) seeding based on the color-coded FA-map. Methods Prospectively collected data of 30 patients undergoing bihemispheric nTMS mapping followed by nTMS-based DTI fiber tracking prior to surgery of motor eloquent high-grade gliomas were analyzed by 2 experienced and 1 unexperienced examiner. The following data were scrutinized for both hemispheres after tractography based on nTMS-motor positive cortical seeds and a 2nd region of interest in one layer of the caudal pons defined by the color-coded FA-map: the pre- and postoperative motor status (day of discharge und 3 months), the closest distance between the tracts and the tumor (TTD), the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC). The latter as an average within the CST as well as specific values in different locations (peritumoral, mesencephal, pontine). Results Lower average FA-values within the affected CST as well as higher average ADC-values are significantly associated with deteriorated postoperative motor function (p = 0.006 and p = 0.026 respectively). Segmental analysis within the CST revealed that the diffusion parameters are especially disturbed on a peritumoral level and that the degree of their impairment correlates with motor deficits (FA p = 0.065, ADC p = 0.007). No significant segmental variation was seen in the healthy hemisphere. The interrater reliability showed perfect agreement for almost all analyzed parameters. Conclusions Adding diffusion weighted imaging derived information on the structural integrity of the nTMS-based tractography results improves the predictive power for postoperative motor outcome. Utilizing a second subcortical ROI which is specifically seeded based on the color-coded FA map increases the tracking quality of the CST independently of the examiner's experience. Further prospective studies are needed to validate the nTMS-based prediction of the patient's outcome.
title: Hidden truths
title: norms in clinical practice
titleType: Subtitle
Creators: name: Tabish, Syeda Momina
Publisher: name: University of Iowa
Year: 2023

description: The idea of the norm holds promise of an elegant and easy to understand method of identifying expected and unusual behaviors. This thesis focuses on understanding the underlying community-based data driven norms - the Hidden Truths, and their relationship with clinical practice. We are motivated by the significance of norms in healthcare and specifically the impact of studying prescription norms to solve real-world problems. In this thesis, we propose the notion of a community based data driven de facto norm that can be used to understand patterns of practices in a health care setting. We propose the desirable properties of de facto norms, and empirically investigate and apply well known statistical and machine learning methods to extract and validate these norms, and explore their real-world applications. The thesis utilizes two real world challenges, as example cases, with respect to over-use of drug prescriptions, one is the antibiotic resistance and second is the opioid epidemic.
description: De facto norms can be a useful tool for comparing and understanding differences in behavior and practices over time as well as across different settings or groups. Overall, community based de facto norms can provide a valuable complement to medical guidelines in shaping behavior and decision-making, as they can capture the complexity and diversity of individual situations and help to identify potential areas for improvement or intervention. This research highlights the applications of de facto norms in real-world scenarios and the importance of studying them for medical decision and policy making and stewardship programs.
Evaluating Tonic and Phasic Variations for User Perception by Moisture Detection on Fingerprint
Creators: name: Isiaka, Fatima
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460207
subject: Modelling and simulation
classificationCode: 460802
subject: Affective computing
classificationCode: 460806
subject: Human-computer interaction

description: Users often experience wetness cursed by stimuli using their hands, and little is known of how this sensitivity in the fingers to moisture is released and the mechanisms underlying this sensory function. This paper, therefore, is aimed to quantify the minimum moisture content required to detect wetness in the user’s first two fingers on the touchpad, the moisture detection threshold and assessment are modulated by the body temperature. The participants were asked to rate the wetness and the sensations based on subjective reports to identify areas of tonic and phasic changes in their physiological response based on a visual analog scaling. The MoistureC detection threshold at a temperature similar to ((3.5) × 10oC), and this temperature reduces at ((2.5) × 10oC) and increases at ((3.7) × 10oC) for warmer conditions similar to stress and relaxed mood of the participants. At neutral settings over the contact area, the hotness in moisture content is similar to the maximum normal body temperature ((3.6) × 10oC). The differences in threshold (baseline) are reflected by the magnitude estimation data that were used for analysis.
The association between fatty acids intake and prostate cancer, and the potential for effect modification from organophosphate pesticides among the agricultural health study population
Creators: name: Sadeghi, Homa
Publisher: name: University of Iowa
Year: 2025
Subjects: Dietary fat intake
Farmers
Fatty Acids
Organophosphate
Pesticide
public abstract
Epidemiology
Prostate Cancer

description: Prostate cancer is one of the most common causes of cancer mortality in the US and globally. Environmental factors such as diet and pesticides may play a role in modifying risk of prostate cancer among men. The existing literature has shown that “The Agricultural Health Study” population exhibits a higher incidence of prostate cancer (PCa) than the general population. Accordingly, I defined the specific aims of this dissertation as:
description: 1. Describing the association between a balanced ratio of omega-6 to omega-3 fatty acids and any potential for effect modification by terbufos and fonofos; 2. Estimating the association between total fat and saturated fatty acids and prostate cancer; and 3. Evaluating the effect of polyunsaturated fatty acids and monounsaturated fatty acids on risk of prostate cancer.
description: In this nested case control study, the effect sizes were estimated by multivariate logistic regression models including the potential confounding variables in the analysis. The results of this dissertation showed that lower ratios of omega-6/omega-3 fatty were associated with decreased risk of prostate cancer and that there was no evidence of effect modification by terbufos or fonofos. Our age-stratified analysis showed significant effect sizes for lower ratios of omega-6 to omega-3 fatty acids only for those who were younger (48-55 years old). For the other two aims of this study, I did not find any significant association between fatty acids and risk of prostate cancer. Furthermore, there was no significant interaction between terbufos/fonofos and total saturated fatty acids, polyunsaturated fatty acids and monounsaturated fatty acids. In conclusion, providing a balance between omega-6 and omega-3 fatty acids may decrease risk of prostate cancer in younger age groups.
The 6df galaxy survey: The near-infrared fundamental plane of early-type galaxies
Creators: name: Magoulas, Christina
name: Springob, Christopher M.
name: Colless, Matthew
name: Jones, D. Heath
name: Campbell, Lachlan A.
name: Lucey, John R.
name: Mould, Jeremy
name: Jarrett, Tom
name: Merson, Alex
name: Brough, Sarah
Publisher: name: Swinburne
Year: 2024

description: We determine the near-infrared Fundamental Plane (FP) for ∼104 early-type galaxies in the 6-degree Field Galaxy Survey (6dFGS). We fit the distribution of central velocity dispersion, near-infrared surface brightness and half-light radius with a 3D Gaussian model using a maximum-likelihood method. The model provides an excellent empirical fit to the observed FP distribution and the method proves robust and unbiased. Tests using simulations show that it gives superior results to regression techniques in the presence of significant and correlated uncertainties in all three parameters, censoring of the data by various selection effects and outliers in the data sample. For the 6dFGS J-band sample we find an FP with , similar to previous near-infrared determinations and consistent with the H- and K-band FPs once allowance is made for differences in mean colour. The overall scatter in Re about the FP is σr = 29 per cent, and is the quadrature sum of an 18 per cent scatter due to observational errors and a 23 per cent intrinsic scatter. Because of the Gaussian distribution of galaxies in FP space, σr is not the distance error, which we find to be σd = 23 per cent. Using group richness and local density as measures of environment, and morphologies based on visual classifications, we find that the FP slopes do not vary with environment or morphology. However, for fixed velocity dispersion and surface brightness, field galaxies are on average 5 per cent larger than galaxies in groups or higher density environments, and the bulges of early-type spirals are on average 10 per cent larger than ellipticals and lenticulars. The residuals about the FP show significant trends with environment, morphology and stellar population. The strongest trend is with age, and we speculate that age is the most important systematic source of offsets from the FP, and may drive the other trends through its correlations with environment, morphology and metallicity. These results will inform our use of the near-infrared FP in deriving relative distances and peculiar velocities for 6dFGS galaxies.
Evaluating Tonic and Phasic Variations for User Perceptionby Moisture Detection on Fingerprint
Creators: name: Isiaka, Fatima
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460207
subject: Modelling and simulation
classificationCode: 460802
subject: Affective computing
classificationCode: 460806
subject: Human-computer interaction

description: Users often experience wetness cursed by stimuli using their hands, and little is known of how this sensitivity in the fingers to moisture is released and the mechanisms underlying this sensory function. This paper, therefore, is aimed to quantify the minimum moisture content required to detect wetness in the user’s first two fingers on the touchpad, the moisture detection threshold and assessment are modulated by the body temperature. The participants were asked to rate the wetness and the sensations based on subjective reports to identify areas of tonic and phasic changes in their physiological response based on a visual analog scaling. The MoistureC detection threshold at a temperature similar to ((3.5) × 10oC), and this temperature reduces at ((2.5) × 10oC) and increases at ((3.7) × 10oC) for warmer conditions similar to stress and relaxed mood of the participants. At neutral settings over the contact area, the hotness in moisture content is similar to the maximum normal body temperature ((3.6) × 10oC). The differences in threshold (baseline) are reflected by the magnitude estimation data that were used for analysis.
The rhetorical art of some Vernon refrain lyrics.
Creators: name: Woollam, Angela M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Literature, Medieval.

description: The dissertation considers how the anonymous authors of six moral and religious pseudo-ballade refrain poems first attested in the late fourteenth-century Vernon manuscript (Oxford, Bodleian Library, MS. Eng. poet.a.1) manipulate devices such as speaking persona, word-play, and allegory in ways that support rhetorical strategies hitherto unrecognized in Middle English lyric. The study begins with stemmatic analyses that identify, as far as is possible from the physical record, the archetypal text, or "work," of each poem. Chapter One then provides an overview of scholarship that has focussed on two important technical devices used in the Vernon refrain lyrics-the speaking voice and the refrain---and articulates how the lyrics use those devices in hitherto unrecognized ways. Chapter One concludes by considering the kinds of word-play found in other Middle English literature, in order to define that found in the Vernon lyrics. In the next six chapters, each of the six "works" is considered as a communicative event. Using mainly historicist, formalist, and reader-response methodologies, I explore, for each poem in turn, how the poet moulds language to signify indirectly so that the message is communicated figuratively, and how the implied audience is cast into a specific role vis-a-vis the communicative action in a way that inflects the message. I also explore how the rhetorical strategies of the poems are informed by various theories of signification, which are defined in relation to the socio-linguistic circumstances and philosophical currents of the time, and consider the poems in relation to other medieval, mostly earlier Middle English, lyrics. In the Conclusion, findings are assembled to indicate how the recovery of the Vernon refrain lyrics' rhetorical art expands the parameters that currently define Middle English lyric. I also turn from considering the implied audience of the "works" to considering the historical audience of the Vernon manuscript, and suggest that the recovery of the Vernon refrain lyrics' rhetorical art bolsters theories that maintain the Vernon manuscript was intended, at least in part, for an upper gentry or aristocratic audience, and that its thorough Englishness is more of a polemic assertion of the strength of the English language than a reflection of socio-linguistic conditions.
Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke
Creators: name: Hochmeister, Sonja
name: Engel, Odilo
name: Adzemovic, Milena Z.
name: Pekar, Thomas
name: Kendlbacher, Paul
name: Zeitelhofer, Manuel
name: Haindl, Michaela
name: Meisel, Andreas
name: Fazekas, Franz
name: Seifert-Held, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives From previous data in animal models of cerebral ischemia, lipocalin-2 (LCN2), a protein related to neutrophil function and cellular iron homeostasis, is supposed to have a value as a biomarker in ischemic stroke patients. Therefore, we examined LCN2 expression in the ischemic brain in an animal model and measured plasma levels of LCN2 in ischemic stroke patients. Methods In the mouse model of transient middle cerebral artery occlusion (tMCAO), LCN2 expression in the brain was analyzed by immunohistochemistry and correlated to cellular nonheme iron deposition up to 42 days after tMCAO. In human stroke patients, plasma levels of LCN2 were determined one week after ischemic stroke. In addition to established predictive parameters such as age, National Institutes of Health Stroke Scale and thrombolytic therapy, LCN2 was included into linear logistic regression modeling to predict clinical outcome at 90 days after stroke. Results Immunohistochemistry revealed expression of LCN2 in the mouse brain already at one day following tMCAO, and the amount of LCN2 subsequently increased with a maximum at 2 weeks after tMCAO. Accumulation of cellular nonheme iron was detectable one week post tMCAO and continued to increase. In ischemic stroke patients, higher plasma levels of LCN2 were associated with a worse clinical outcome at 90 days and with the occurrence of post-stroke infections. Conclusions LCN2 is expressed in the ischemic brain after temporary experimental ischemia and paralleled by the accumulation of cellular nonheme iron. Plasma levels of LCN2 measured in patients one week after ischemic stroke contribute to the prediction of clinical outcome at 90 days and reflect the systemic response to post-stroke infections.
title: A novel approach for measuring resistance to Hyrax rapid maxillary expansion
title: a pre-clinical study
titleType: Subtitle
Creators: name: Kessel, Jayne Alyda
Publisher: name: University of Iowa
Year: 2022
Subjects: Expansion
Forces
RME
public abstract
Orthodontics

description: Introduction Maxillary constriction is often associated with posterior crossbites, functional shifts, maxillary crowding, and asymmetric jaw growth. The current standard of care for treating a constricted maxilla is rapid maxillary expansion (RME), which uses high levels of force to separate the midpalatal suture. However, few studies have attempted to estimate the forces produced by RME appliances. The purpose of this study is to develop a novel method of evaluating the resistance to Hyrax expansion.
description: Materials and Methods
description: Five Dentaurum Palex® Maxi 12mm expansion screws were acquired for testing, and a separate expansion key was fabricated for each screw. An apparatus was fabricated to allow measurement of the force required to turn an expansion screw when subjected to defined loading conditions. Each screw was tested under thirteen loading conditions for each of four situations: unmodified, with reduced friction, with bent arms, and soldered into an expander appliance. The forces measured in these situations were compared statistically.
description: Results
description: A statistically significant difference in the turning force existed between the initial and frictionless situations when loading was below 5000g, between the frictionless and bent situations when loading reached 2000g or higher (except the 4000g load), and between the bent and soldered situations when loading was unmodified (0g). Although Spearman’s rank coefficients (r) indicated no correlation between loading condition and force in the initial situation for two of the five expanders (r=0.24, p=0.437; r=0.21, p=0.494), there was significantly strong correlation in the initial situation for the other three expanders (r=0.84-0.99, p<0.05 in each instance). There was also significantly strong correlation between loading condition and force for all five expanders in each of the other three situations (frictionless, bent, and soldered).
description: Conclusions
description: Under the conditions of this experiment, we conclude the following: Friction is a confounding factor when measuring the forces resisting expansion of the screw. Frictional forces resisting expansion vary between individual screws. Bending an expansion screw into a clinical configuration affects the force levels needed to turn the screw. Soldering an expansion screw to fabricate an expansion appliance may have an effect on the force levels needed to turn the screw. Based on these findings, recommendations for using this method are given. This novel pre-clinical measurement approach will be translated to a clinical pilot study with orthodontic patients.
Bereaved family members’ perceptions of the quality of end-of-life care across four types of inpatient care settings
Creators: name: Stajduhar, Kelli I.
name: Sawatzky, Richard
name: Robin Cohen, S.
name: Heyland, Daren K
name: Allan, Diane
name: Bidgood, Darcee
name: Norgrove, Leah
name: Gadermann, Anne
Publisher: name: BioMed Central
Year: 2017

description: Background: The aims of this study were to gain a better understanding of how bereaved family members perceive the quality of EOL care by comparing their satisfaction with quality of end-of-life care across four different settings and by additionally examining the extent to which demographic characteristics and psychological variables (resilience, optimism, grief) explain variation in satisfaction. Methods A cross-sectional mail-out survey was conducted of bereaved family members of patients who had died in extended care units (n = 63), intensive care units (n = 30), medical care units (n = 140) and palliative care units (n = 155). 1254 death records were screened and 712 bereaved family caregivers were identified as eligible, of which 558 (who were initially contacted by mail and then followed up by phone) agreed to receive a questionnaire and 388 returned a completed questionnaire (response rate of 70%). Measures included satisfaction with end-of-life care (CANHELP- Canadian Health Care Evaluation Project - family caregiver bereavement version; scores range from 0 = not at all satisfied to 5 = completely satisfied), grief (Texas Revised Inventory of Grief (TRIG)), optimism (Life Orientation Test – Revised) and resilience (The Resilience Scale). ANCOVA and multivariate linear regression were used to analyze the data. Results Family members experienced significantly lower satisfaction in MCU (mean = 3.69) relative to other settings (means of 3.90 [MCU], 4.14 [ICU], and 4.00 [PCU]; F (3371) = 8.30, p = .000). Statistically significant differences were also observed for CANHELP subscales of “doctor and nurse care”, “illness management”, “health services” and “communication”. The regression model explained 18.9% of the variance in the CANHELP total scale, and between 11.8% and 27.8% of the variance in the subscales. Explained variance in the CANHELP total score was attributable to the setting of care and psychological characteristics of family members (44%), in particular resilience. Conclusion Findings suggest room for improvement across all settings of care, but improving quality in acute care and palliative care should be a priority. Resiliency appears to be an important psychological characteristic in influencing how family members appraise care quality and point to possible sites for targeted intervention.
Testing the NBN vision: Can aerial construction truly deliver 'a historic nation-building investment focussed on Australia's long-term national interest'?
Creators: name: Kelso, Ross
Publisher: name: Swinburne
Year: 2024

description: The Rudd government announced in 2009 its intention to roll out a fibre-to-the-home optical fibre-based national broadband network, proclaiming that the initiative would be a historic nation-building investment focussed on Australia's long-term national interest. This paper examines the appropriateness of such a vision where the network, being a government-mandated provider of last resort carrying lifeline telecommunication services, is to rely on infrastructure held up by electricity poles. An initiative so constructed outstandingly fails the basic notion of creating 21st century broadband as a building block of Australia's future digital economy.
The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions
Creators: name: Matz, Joachim M.
name: Goosmann, Christian
name: Brinkmann, Volker
name: Grützke, Josephine
name: Ingmundson, Alyssa
name: Matuschewski, Kai
name: Kooij, Taco W. A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The erythrocyte is an extraordinary host cell for intracellular pathogens and requires extensive remodelling to become permissive for infection. Malaria parasites modify their host red blood cells through protein export to acquire nutrients and evade immune responses. Endogenous fluorescent tagging of three signature proteins of the Plasmodium berghei translocon of exported proteins (PTEX), heat shock protein 101, exported protein 2 (EXP2), and PTEX88, revealed motile, tubular extensions of the parasitophorous vacuole that protrude from the parasite far into the red blood cell. EXP2 displays a more prominent presence at the periphery of the parasite, consistent with its proposed role in pore formation. The tubular compartment is most prominent during trophozoite growth. Distinct spatiotemporal expression of individual PTEX components during sporogony and liver-stage development indicates additional functions and tight regulation of the PTEX translocon during parasite life cycle progression. Together, live cell imaging and correlative light and electron microscopy permitted previously unrecognized spatiotemporal and subcellular resolution of PTEX-containing tubules in murine malaria parasites. These findings further refine current models for Plasmodium-induced erythrocyte makeover.
Letbanens Koncept
Creators: name: Olesen, Mette
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: I gennem denne artikel belyses argumenter bag implementering af letbanesystemer, samt forskellige koncepter hvormed letbaner er implementeret i mellemstore europæiske byer. Artiklen er bygget op om to centrale elementer. I første del identificeres de globale diskurser, der eksisterer omkring letbaner. I anden del beskrives processen med at forme et koncept for letbaneprojekter i en lokal kontekst. Dette gøres med Bergen Bybane som primær case og med reference til øvrige europæiske cases. Artiklen argumenterer for, at letbaner bør anskues som mere end et transportsystem der fragter passagerer fra a til b. Resultaterne fra casestudier præsenteret i denne artikel viser, at argumenterne for at implementere letbaner ofte ikke er funderet i et økonomisk rationale, men er en politisk beslutning om at skabe en konkurrencedygtig byudvikling.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
UBA baut Antworten
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Plusenergiehaus
subject: Umweltgerechtes Bauen
subject: Plus-Energie-Haus
subject: Erweiterungsbau
subject: Bauprojekt
subject: Nachhaltiges Bauen
subject: Das UBA

description: Am Hauptsitz des UBA in Dessau-Roßlau wurde im August 2023 ein Erweiterungsbau mit 111 Büroarbeitsplätzen fertiggestellt, der Plus-Energie-Standard haben soll. Das heißt, dass das Gebäude übers Jahr gerechnet weniger Energie verbraucht, als es selbst erzeugt. In diesem Faltblatt stellen wir Ihnen das Bauprojekt kurz vor. Erfahren Sie mehr über die wichtigsten Eckdaten zum Projekt, das architektonische und energetische Konzept, die verwendeten Baustoffe, die Planung der Außenanlagen und die "Kunst am Bau". Quelle: umweltbundesamt.de
description: Am Hauptsitz des ⁠UBA⁠ in Dessau-Roßlau wurde im August 2023 ein Erweiterungsbau mit 111 Büroarbeitsplätzen fertiggestellt, der Plus-Energie-Standard haben soll. Das heißt, dass das Gebäude übers Jahr gerechnet weniger Energie verbraucht, als es selbst erzeugt. In diesem Faltblatt stellen wir Ihnen das Bauprojekt kurz vor. Erfahren Sie mehr über die wichtigsten Eckdaten zum Projekt, das architektonische und energetische Konzept, die verwendeten Baustoffe, die Planung der Außenanlagen und die "Kunst am Bau".
Light railways and busways as key driver for sustainable urban development
Creators: name: Stojanovski, Todor
name: Lundström, Mats Johan
name: Haas, Tigran
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Sustainable urbanism and good placemaking revolve around creating and maintaining sustainable and attractive places, by reviving planning and urban design paradigms, by experimenting and innovating and by building synergies between the old and the new. The expectations for wide accessibility and networking are very high and the challenge today is to integrate and improve the efficiency and effectiveness of urban and transport systems. The transports have to fulfil the ongoing demands for enhanced efficiency, comfort, safety and speed, as well as the environmental factors in the light of global climate change and energy crisis. One accent in the last 20 years has been on transit‐oriented development (TOD), compact cities and urbanity‐empowering public transports like light railways or light rail transit (LRT) or bus rapid transit (BRT) with its busways as key drivers for sustainable neighbourhoods. TOD in a Swedish (European) perspective is by no means a new idea. Three cases of newer light railway and busway projects (Stockholm, Gothenburg and Norrkoping) are explored in this article and they are seen through a historical overview of the TOD experiences in Sweden and around the world. We also investigate and draw attention to the values of placemaking and sustainable urbanism via the advantages and disadvantages of the urban and regional public transport systems and TOD principles.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
The impact of a physician detailing and sampling program for generic atorvastatin: an interrupted time series analysis
Creators: name: Worthington, Heather
name: Cheng, Lucy
name: Majumdar, Sumit R.
name: Morgan, Steve
name: Raymond, Colette B.
name: Soumerai, Stephen B.
name: Law, Michael R.
Publisher: name: BioMed Central
Year: 2017

description: Background: In 2011, Manitoba implemented a province-wide program of physician detailing and free sampling for generic atorvastatin to increase use of this generic statin. We examined the impact of this unique combined program of detailing and sampling for generic atorvastatin on the use and cost of statin medicines, market share of generic atorvastatin, the choice of starting statin for new users, and switching from a branded statin to generic atorvastatin. Methods: We conducted a retrospective study of Manitoba insurance claims data for all continuously enrolled patients who filled one or more prescriptions for a statin between 2008 and 2013. Data were linked to physician-level data on the number of detailing visits and sample provision. We used interrupted time series analyses to assess policy-related changes in the use and cost of statin medicines, market share of generic atorvastatin, the choice of starting statin for new users, and switching from a branded statin to generic atorvastatin. Results: The detailing program reached 31% (651/2103) of physicians who prescribed a statin during the study period. Collectively, these physicians prescribed 61% of statins dispensed in the province. Free sample cards were provided to 61% (394/651) of the detailed physicians. The program did not change the level or trend in the overall statin use rate and the total cost of statins or increase the number of patients switching from another branded statin to generic atorvastatin. We found the program had a small impact on atorvastatin’s market share of new prescriptions, with a level increase of 2.6%. Conclusions: Though physician detailers were skilled at targeting high-prescribing physicians, a combined program of detailing visits and sample provision for generic atorvastatin did not lower overall statin costs or lead to switching from branded statins to the generic. The preceding introduction of generic atorvastatin appeared sufficient to modify prescribing patterns and decrease costs.
Beta1 integrin modulates the anchorage independent growth, invasion and migration of prostate cancer cell line PC3
Creators: name: Andrews, Natalie M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Biochemistry.

description: Integrins provide mechanical continuity between the extra- and intracellular environments. Upon binding to extracellular matrix (ECM), integrins interact with downstream effectors to promote cell adhesion, proliferation and migration. In contrast to its well-known role in adhesion, we have found that beta 1 integrin is also involved in the anchorage independent (AI) growth of prostate tumor cells. In concurrence with our previous findings, stable depletion of beta1 integrin in PC3 cells using an shRNA approach resulted in the complete inability of cells to form colonies in soft agarose, while adherent monolayer growth remained unaffected. In order to address the mechanism for beta1 integrin dependent AI growth, we examined the expression and localization of beta-catenin and E-cadherin, both of which are known to modulate AI growth. Migration and invasion through matrigel were found to be impeded by depletion of beta1 integrin. A qPCR array identified potential downstream targets that could be altered as a result of beta1 integrin depletion, these were further examined in all cell lines and it was found that TGFbeta1 is reduced in shITGB1 expressing cells. Taken together, these findings suggest a role for both beta1 integrin in driving anchorage independent growth and invasion of cancer cells.
Application of miR-200c for regenerative endodontics
Creators: name: Krongbaramee, Tadkamol
Publisher: name: University of Iowa
Year: 2024
Subjects: endodontics
microRNA
non-viral nanoparticle
regeneration
public abstract
Inflammation

description: microRNAs (miRs) play an important role in post-transcriptional regulation in inflammation and regeneration and have emerged as innovative tools for the diagnosis and treatment of disease. miR-200c has previously been demonstrated to potently regulate tooth development, modulate inflammation, and promote osteogenesis, and could also be a candidate to assist in regenerative endodontic procedures. Therefore, my research focuses on characterizing miR-200c in tooth inflammation to determine its potential in attenuating inflammation and promoting odontogenesis in dental pulp stem cells. Our findings revealed that plasmid DNA encoding miR-200c using non-viral transfection methods may potentially be used as therapeutic approaches for vital pulp therapy and endodontic regeneration by attenuating inflammation and promoting odontogenic differentiation. As a dental clinician, I aspire to incorporate novel research approaches such as these into innovative clinical therapies to treat and restore inflamed teeth ultimately improving their long-term survival.
Kollektiv Trafikplan for Nordjylland 2013-16
Creators: name: Trankjær, Christian
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: NT’s bestyrelse vedtog den 27. april ’Kollektiv Trafikplan for Nordjylland 2013-16’ efter den havde været i høring i otte uger hos NT’s ejere og offentligheden. Der er bred opbakning blandt NT’s ejere til principperne og målene i planen og dermed en tro på, at im- plementering af planen vil betyde en mere effektiv kollektiv trafik med flere passagerer til følge. Dog be- mærker de fleste af høringsparterne, at det kan blive vanskeligt at tilvejebringe den finansiering, der er nødvendig for trafikplanens gennemførelse. Kommunerne og regionen har i høringsperioden haft mulighed for at kommentere på de seks indsatsområder, som trafikplanen indeholder: • Forstærkning af busnettet • Udvikling af banebetjeningen • Videreudvikling af Flextrafik • Opgradering af terminaler og stoppesteder • Bedre trafikinfo • Bedre klima- og miljøpræstation I forhold til punkterne vedrørende banebetjening, flextrafik, trafikinfo og klima og miljø er der generelt tilslutning til visionerne, målene og initiativerne i planen. Der er og opbakning til principperne for forstærkning af busnettet, som indebærer, at busdriften udvides i de korridorer, hvor der er størst potentiale for at tiltrække flere passagerer. Kommunernes og regionens involvering vil dog afhænge af de økonomiske muligheder. Trafikplanens forslag til forstærkning skal derfor ses som et katalog, og det må i den årlige budgetproces afklares med ejerne, hvilke initiativer, der kan iværksættes. Det samme gør sig gældende for opgradering af terminaler og stoppesteder, hvor der er tilslutning til et fælles koncept for anlæg, vedligehold og drift. Kommunernes involvering vil dog afhænge af de økonomiske muligheder. Da den kommunale medfinansiering er usikker udarbejder NT i samarbejde med kommunerne en ansøg- ning til Trafikstyrelsens Fremkommelighedspulje i efteråret 2012 om statslig medfinansiering af initiativerne. Om kommunerne helt eller delvist har økonomisk mulighed for at være medfinansierende afklares i ansøgningsprocessen.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Augmentation and extrapolation of streamflow and rainfall datasets using deep learning
Creators: name: Sit, Muhammed
Publisher: name: University of Iowa
Year: 2023
Subjects: deep learning
rainfall
streamflow
time-series analysis
Artificial intelligence
public abstract
Computer Vision
Machine Learning

description: The literature on deep learning applications for hydrologic research could be broadly summarized as repeated usage of the similar deep learning architectures for new regions without comparing to operational and/or baseline physical or conceptual methods. This is mostly because earth scientists are not deep learning practitioners at core, and for them, deep learning architectures are mostly individual tools that they utilize for isolated tasks. To show how different architectures could serve different purposes in better and intelligent disaster monitoring and, consequently, to pave the way for better deep learning utilization in the Earth science domain, this study presents a framework to forecast Earth systems phenomena and communicate the findings.
description: This study aims to present streamflow forecasting and rainfall nowcasting as tasks that are tackled cumulatively on top of preliminary studies, such as benchmark dataset preparation and augmentation via deep learning. To this extent, for both streamflow and rainfall studies, this study contributes by introducing comprehensive benchmark datasets, namely WaterBench and IowaRain, respectively, that could be used in evaluation of forecasting approaches by the community. Furthermore, in an attempt to rectify the problem of limited data from sensor and radar networks, this study employs both datasets to explore the augmentation of Earth data with novel deep neural network architectures, temporally for rainfall and spatially for streamflow. Finally, novel deep learning approaches are presented for forecasts of streamflow and rainfall, where the datasets presented in this study are used and effects of the augmented datasets in forecasting Earth phenomena are evaluated.
description: Beyond methodology choices, there is a reproducibility problem in the literature that makes scientific advancement more difficult. In order to provide a step towards better scientific advancement in machine learning studies for earth science challenges and also to bridge domain scientists as well as people in the field without technical knowledge to deep learning practices and applications, this study presents a web platform where deep learning models can be explored easily by running them on web browsers.