cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lorentzian Quantum Cosmology
Creators: name: Feldbrugge, Job
name: Lehners, Jean-Luc
name: Turok, Neil
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We argue that the Lorentzian path integral is a better starting point for quantum cosmology than the Euclidean version. In particular, we revisit the mini-superspace calculation of the Feynman path integral for quantum gravity with a positive cosmological constant. Instead of rotating to Euclidean time, we deform the contour of integration over metrics into the complex plane, exploiting Picard-Lefschetz theory to transform the path integral from a conditionally convergent integral into an absolutely convergent one. We show that this procedure unambiguously determines which semiclassical saddle point solutions are relevant to the quantum mechanical amplitude. Imposing "no-boundary" initial conditions, i.e., restricting attention to regular, complex metrics with no initial boundary, we find that the dominant saddle contributes a semiclassical exponential factor which is precisely the {\it inverse} of the famous Hartle-Hawking result.
description: 44 pages, 8 figures
The production of primordial $J/ψ$ in p+p and relativistic heavy-ion collisions
Creators: name: Song, Taesoo
name: Aichelin, Joerg
name: Bratkovskaya, Elena
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: $J/ψ$ observables of p+p collisions at $\sqrt{s}=$ 200 GeV and 2.76 TeV are calculated using the PYTHIA event generator for the production of $c$ and $\bar c$ and the Wigner density formalism. The charm quark momentum from PYTHIA is tuned in such a way that the transverse momentum and rapidity distribution correspond to the Fixed-Order Next-to-Leading Logarithm (FONLL) calculations and hence to the experimental data for open charm mesons. Using the Wigner density of the charmonium wave function we calculate for each charm quark pair the probability to form a charmonium. As a result, the experimental data on the total $J/ψ$ yield, its rapidity and transverse momentum distribution as well as the fractions of feed-down from excited states of charmonium are reproduced. Applying the same approach to relativistic heavy-ion collisions, we find, if quark gluon plasma (QGP) effects are ignored, a considerable enhancement of the primordial $J/ψ$'s.
description: 9 pages, 7 figures
Integrating Covariates into Social Relations Models: A Plausible Values Approach for Handling Measurement Error in Perceiver and Target Effects
Creators: name: Lüdtke, Oliver
name: Robitzsch, Alexander
name: Trautwein, Ulrich
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: The Social Relations Model (SRM) is a conceptual and analytical approach to examining dyadic behaviors and interpersonal perceptions within groups. In an SRM, the perceiver effect describes a person's tendency to perceive other group members in a certain way, whereas the target effect measures the tendency to be perceived by others in certain ways. In SRM research, it is often of interest to relate these individual SRM effects to covariates. However, the estimated individual SRM effects might not provide a very reliable measure of the true, unobserved SRM effects, resulting in distorted estimates of associations with other variables. This article introduces a plausible values approach that allows users to correct for measurement error when assessing the association of individual SRM effects with other individual difference variables. In the plausible values approach, the latent, true individual SRM effects are treated as missing values and are imputed from an imputation model by applying Bayesian estimation techniques. In a simulation study, the statistical properties of the plausible values approach are compared with two approaches that have been used in previous research. A data example from educational psychology is presented to illustrate how the plausible values approach can be implemented with the software WinBUGS.
An assessment of plastic ingestion in selected Australian pinniped species
Creators: name: Kelly, Brooke
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Pollution of the marine environment by plastic debris is a global issue, with harmful biological and ecotoxicological impacts recorded for a plethora of marine species. Scats of Australian sea lions (Neophoca cinerea), Australian fur seals (Arctocephalus pusillus doriferus) and long nosed fur seals (Arctocephalus forsteri) of southern Australia were analysed for plastic ingestion. The current study is the first record of plastic ingestion in Australian sea lions. The frequency of occurrence of microplastic ingestion varies between colonies - Kangaroo Island(64.71%, n=17), Lady Julia Percy Island (50%, n=6) and Phillip Island (21.43%, n=14). There isa significant relationship between the amounts of microplastics ingested by pinnipeds and the microplastics polluting waters directly surrounding studied colonies, suggesting that plastic loads of nearby urban centres are reflected in microplastics being ingested. Over one third (38.7%) of ingested microplastics were small (<2mm) blue fibres, suggesting that there exists a major source of microplastic pollution of this type in southern Australia, or perhaps that prey species selectively ingest microplastics. Plastics are likely ingested through trophic transfer, but direct ingestion may occur during benthic foraging, similar to the ingestion of gastroliths. Methods of microplastic extraction from pinniped scats are recommended for standardisation
Non-local initial problem for second order time-fractional and space-singular equation
Creators: name: Karimov, Erkinjon
name: Mamchuev, Murat
name: Ruzhansky, Michael
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35R11, 33E12

description: In this work, we consider an initial problem for second order partial differential equations with Caputo fractional derivatives in the time-variable and Bessel operator in the space-variable. For non-local boundary conditions, we present a solution of this problem in an explicit form representing it by the Fourier-Bessel series. The obtained solution is written in terms of multinomial Mittag-Leffler functions and first kind Bessel functions.
description: 9 pages
UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of Bryophyllum pinnatum; antioxidant properties, anticholinesterase activity and in silico studies
Creators: name: Ogidigo, Joyce Oloaigbe
name: Anosike, Chioma Assumpta
name: Joshua, Parker Elijah
name: Ibeji, Collins U.
name: Ekpo, Daniel Emmanuel
name: Nwanguma, Bennett C.
name: Nwodo, Okwesili Fred Chiletugo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Plant Biology

description: Bryophyllum pinnatum (Lam.) Oken (Crassulaceae) is used traditionally to treat many ailments. This study characterizes the constituents of B. pinnatum flavonoid-rich fraction (BPFRF) and investigates their antioxidant and anticholinesterase activity using in vitro and in silico approaches. Methanol extract of B. pinnatum leaves was partitioned to yield the ethyl acetate fraction. BPFRF was isolated from the ethyl acetate fraction and purified. The constituent flavonoids were structurally characterized using UPLC-PDA-MS2. Antioxidant activity (DPPH), Fe2+-induced lipid peroxidation (LP) and anticholinesterase activity (Ellman’s method) of the BPFRF and standards (ascorbic acid and rivastigmine) across a concentration range of 3.125–100 μg/mL were evaluated in vitro for 4 months. Molecular docking was performed to give insight into the binding potentials of BPFRF constituents against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). UPLC-PDA-MS2 analysis of BPFRF identified carlinoside, quercetin (most dominant), luteolin, isorhamnetin, luteolin-7-glucoside. Carlinoside was first reported in this plant. BPFRF significantly inhibited DPPH radical (IC50 = 7.382 ± 0.79 µg/mL) and LP (IC50 = 7.182 ± 0.60 µg/mL) better than quercetin and ascorbic acid. Also, BPFRF exhibited potent inhibition against AChE and BuChE with IC50 values of 22.283 ± 0.27 µg/mL and 33.437 ± 1.46 µg/mL, respectively compared to quercetin and rivastigmine. Docking studies revealed that luteolin-7-glucoside, carlinoside and quercetin interact effectively with crucial amino acid residues of AChE and BuChE through hydrogen bonds. BPFRF possesses an excellent natural source of cholinesterase inhibitor and antioxidant. The material could be further explored for the potential treatment of oxidative damage and cholinergic dysfunction in Alzheimer’s disease.
Automatic brain labeling via multi-atlas guided fully convolutional networks
Creators: name: Cao, Xiaohuan
name: Fang, Longwei
name: Rekik, Islem
name: Shen, Dinggang
name: He, Huiguang
name: Nie, Dong
name: Zhang, Lichi
name: Lee, Seong-Whan
Publisher: name: Elsevier
Year: 2018

description: Multi-atlas-based methods are commonly used for MR brain image labeling, which alleviates the burdening and time-consuming task of manual labeling in neuroimaging analysis studies. Traditionally, multi-atlas-based methods first register multiple atlases to the target image, and then propagate the labels from the labeled atlases to the unlabeled target image. However, the registration step involves non-rigid alignment, which is often time-consuming and might lack high accuracy. Alternatively, patch-based methods have shown promise in relaxing the demand for accurate registration, but they often require the use of hand-crafted features. Recently, deep learning techniques have demonstrated their effectiveness in image labeling, by automatically learning comprehensive appearance features from training images. In this paper, we propose a multi-atlas guided fully convolutional network (MA-FCN) for automatic image labeling, which aims at further improving the labeling performance with the aid of prior knowledge from the training atlases. Specifically, we train our MA-FCN model in a patch-based manner, where the input data consists of not only a training image patch but also a set of its neighboring (i.e., most similar) affine-aligned atlas patches. The guidance information from neighboring atlas patches can help boost the discriminative ability of the learned FCN. Experimental results on different datasets demonstrate the effectiveness of our proposed method, by significantly outperforming the conventional FCN and several state-of-the-art MR brain labeling methods.
Synthesis of novel N-(p-toluenesulfonyl)aminophosphonates and evaluation of their biological properties
Creators: name: Rafał Karpowicz
name: Jarosław Lewkowski
name: Małgorzata Stasiak
name: Czopor, Aleksandra
name: Tokarz, Paulina
name: Król, Adrianna
name: Rogacz, Diana
name: Rychter, Piotr
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: The synthesis of a series of N-sulfonylaminophosphonates 2aA-2dC and evaluation of their cytotoxicity and ecotoxicity is described. N-sulfonylaminophsophonates 2aA-2dC were obtained by addition of dialkyl phosphites to azomethine bonds of sulfonimines 1a-d in dichloromethane, and the reaction was mediated by potassium carbonate. Sulfonimines 1a-d were synthesized by direct condensation of selected aldehydes with p-toluenesulfonamide catalyzed by titanium(IV) ethoxide. The cytotoxicity of compounds 2aB-2cB, 2aC-2cC, 2bA and 2dA against normal primary human lymphocytes, non-small cell lung cancer cells A549, promyelocytic leukemia cells HL-60 and glioblastoma astrocytoma cells U87 was found to be very low. The phytotoxicity of 2dC against monocotyledonous oat (A. sativa) and dicotyledonous radish (R. sativus) was measured and the compound was found to be practically not toxic for two model plants. Lack of toxicity for marine bacteria A. fischeri has been also detected. However, the compound 2dC was found to be significantly toxic for freshwater, European crustaceans H. incongruens (ostracods).
Additional file 1 of Impact of Paenarthrobacter ureafaciens ZF1 on the soil enzyme activity and microbial community during the bioremediation of atrazine-contaminated soils
Creators: name: Zhang, Zhifei
name: Fu, Qian
name: Xiao, Changyixin
name: Ding, Mingyue
name: Liang, Dong
name: Li, Haitao
name: Liu, Rongmei
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Relative abundance of the top 10 predominant bacteria in soil bacterial community at phyla level. Table S2. Relative abundance of the top 10 predominant bacteria in soil bacterial community at class level. Table S3. Relative abundance of the top 10 predominant bacteria in soil bacterial community at order level. Table S4. Relative abundance of the top 10 predominant bacteria in soil bacterial community at family level. Table S5. Relative abundance of the top 10 predominant bacteria in soil bacterial community at genus level. Table S6. Information of sequencing parameters for different samples.
Universality and unconventional enhancement of flux-flow resistivity in Ba(Fe$_{1-x}$Co$_x$)$_2$As$_2$
Creators: name: Huang, Xinyi
name: Haney, D. J.
name: Singh, Y. P.
name: Hu, T.
name: Xiao, H.
name: Wen, Hai-Hu
name: Dzero, M.
name: Almasan, Carmen. C.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Measurements of the current-voltage characteristics were performed on Ba(Fe$_{1-x}$Co$_x$)$_2$As$_2$ single crystals with doping level $0.044 \leq x \leq 0.1$. An unconventional increase in the flux-flow resistivity $ρ_{\rm ff}$ with decreasing magnetic field was observed across this doping range. Such an abnormal field dependence of flux-flow resistivity is in contrast with the linear field dependence of $ρ_{\rm ff}$ in conventional type-II superconductors, but is similar to the behavior recently observed in the heavy-fermion superconductor CeCoIn$_5$. A significantly enhanced $ρ_{\rm ff}$ was found for the x=0.06 single crystals, implying a strong single-particle energy dissipation around the vortex cores. At different temperatures and fields and for a given doping concentration, the normalized $ρ_{\rm ff}$ scales with normalized field and temperature. The doping level dependence of these parameters strongly suggests that the abnormal upturn flux-flow resisitivity is likely related to the enhancement of spin fluctuations around the vortex cores of the optimally doped samples.
description: 9 pages, 7 figures
Assessing the sustainability of the Nigerian urban reproductive health initiative facility-level programming: longitudinal analysis of service quality
Creators: name: McGuire, Courtney
name: Guilkey, David K.
name: Speizer, Ilene S.
name: Lance, Peter M.
name: Calhoun, Lisa M.
name: Heller, Caroline
Publisher: name: Springer Nature
Year: 2019

description: BackgroundTo date, there is little information on the sustainability of family planning (FP) service quality after completion of a donor-funded program. This paper examines the sustainability of the Nigerian Urban Reproductive Health Initiative (NURHI) program on quality of FP services in two cities: Ilorin, where the program ended in March 2015 and Kaduna where the program continued.MethodsData come from three time periods: 2011, before program implementation; 2014, near Phase 1 completion; and 2017, two-years post Phase 1. In 2011, we undertook a facility audit and provider surveys in all public sector facilities in each city as well as all private facilities mentioned as the source for FP or maternal, newborn, and child health services in a 2010 women's household survey. In 2014 and 2017, we returned to the same facilities to undertake the facility audit and provider surveys. Quality is measured from principal component analyses of 30 items from the facility audit and provider surveys. Service use outcomes are measured as the ratio of FP clients (total and new) to the number of reproductive health staff members. Multivariate random effect models are estimated to examine changes in the outcomes over time, between NURHI and non-NURHI facilities and by city.ResultsWe demonstrate that NURHI facilities had better quality and higher service use than non-NURHI facilities. Further, while quality of services was higher in Ilorin in 2011, by 2014 and three years later (2017), the quality was better in Kaduna where the program continued. In addition, while no difference was found in service utilization between Ilorin and Kaduna in 2014, by 2017, Kaduna had significantly more new FP users than Ilorin.ConclusionsIn Ilorin, quality of services did not continue its strong upward trend after the program ended. Programs need to consider long-term strategies that support continuation of program components post program implementation. This may include ensuring continued training of providers and addressing equipment and commodity stock-outs through system changes rather than specific facility-level changes. The findings from this study can be used to inform future programs seeking to improve quality of FP services in a sustainable manner.
Developmental and taxonomic studies of Sydney Harbour kinorhyncha
Creators: name: Brown, Rosemary Jean
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The principal aim of the research project reported in this thesis is the description of kinorhynch head processes to provide data for taxonomic and systematic use. Observations are recorded of the morphology and ultrastructural histology of the scalids (head processes) of Kinorhynchus phyllotropis (Brown and Higgins, 1983) - the first kinorhynch from Australia to be described.
Multiple Shooting Shadowing for Sensitivity Analysis of Chaotic Dynamical Systems
Creators: name: Blonigan, Patrick J.
name: Wang, Qiqi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Sensitivity analysis methods are important tools for research and design with simulations. Many important simulations exhibit chaotic dynamics, including scale-resolving turbulent fluid flow simulations. Unfortunately, conventional sensitivity analysis methods are unable to compute useful gradient information for long-time-averaged quantities in chaotic dynamical systems. Sensitivity analysis with least squares shadowing (LSS) can compute useful gradient information for a number of chaotic systems, including simulations of chaotic vortex shedding and homogeneous isotropic turbulence. However, this gradient information comes at a very high computational cost. This paper presents multiple shooting shadowing (MSS), a more computationally efficient shadowing approach than the original LSS approach. Through an analysis of the convergence rate of MSS, it is shown that MSS can have lower memory usage and run time than LSS.
description: Preprint submitted to the Journal of Computational Physics
Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet
Creators: name: Nazri, Khuzaidatul Azidah Ahmad
name: Saad, Qodriyah Haji Mohd
name: Fauzi, Norsyahida Mohd
name: Buang, Fhataheya
name: Jantan, Ibrahim
name: Jubri, Zakiah
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Gynura procumbens (Lour.) Merr. (Asteraceae) has been reported to have various pharmacological activities including anti-inflammatory effects. This study sought to determine whether Gynura procumbens (GP) could improve vascular reactivity by suppressing inflammation in postmenopausal rats fed with five-times heated palm oil (5HPO) diet. Forty-eight female Sprague-Dawley rats were randomly divided into sham [non-ovariectomized; grouped as control, GP extracts (250 and 500 mg/kg), atorvastatin (ATV, 10 mg/kg)] and postmenopausal (PM) groups [ovariectomized rats fed with 5HPO; grouped as PM, GP extracts (250 and 500 mg/kg) and ATV (10 mg/kg)]. Each group (n = 6) was either supplemented with GP extract or ATV orally once daily for 6 months. In comparison with the untreated PM group, 250 and 500 mg/kg GP supplementation to PM groups reduced the systolic blood pressure (103 ± 2.7, 86 ± 2.4 vs. 156 ± 7.83 mmHg, p < 0.05), intima-media thickness (101.28 ± 3.4, 93.91 ± 2.93 vs. 143.78 ± 3.31 µM), vasoconstriction percentage induced by phenylephrine (102.5%, 88.3%, vs. 51.8%), sICAM-1 (0.49, 0.26 vs. 0.56 pg/mL) and sVCAM-1 (0.39, 0.25 vs. 0.45 pg/mL). GP extract supplementation increased vasorelaxation percentage induced by acetylcholine (78.4% vs. 47.3%) and sodium nitroprusside (84.2% vs. 53.7%), increased changes in plasma nitric oxide level (1.25%, 1.31% vs. 1.9%), and suppressed the elevation of TNF-α (0.39 vs. 1.02 pg/mL), IL-6 (0.43 vs. 0.77 pg/mL) and CRP (0.29 vs. 0.69 ng/mL) in the PM groups. GP extract might improve vascular dysfunction by suppressing the inflammatory response, consequently preventing blood pressure elevation.
Kinetic Effects in Dynamic Wetting
Creators: name: Sprittles, James E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The maximum speed at which a liquid can wet a solid is limited by the need to displace gas lubrication films in front of the moving contact line. The characteristic height of these films is often comparable to the mean free path in the gas so that hydrodynamic models do not adequately describe the flow physics. This Letter develops a model which incorporates kinetic effects in the gas, via the Boltzmann equation, and can predict experimentally-observed increases in the maximum speed of wetting when (a) the liquid's viscosity is varied, (b) the ambient gas pressure is reduced or (c) the meniscus is confined.
description: Accepted for publication in Physical Review Letters
B cell-Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer
Creators: name: Harris, Cameron
name: Pylayeva-Gupta, Yuliya
name: McRee, Autumn J.
name: DeNardo, David G.
name: Greene, Kevin
name: Michaud, Daniel
name: Lee, Samuel J.
name: Rashid, Naim U.
name: Yeh, Jen Jen
name: Fields, Ryan C.
name: Vincent, Benjamin G.
name: Gupta, Gaorav P.
name: Hawkins, William G.
name: Goldman, Emily C.
name: Mirlekar, Bhalchandra
name: Vignali, Dario A.A.
name: Kren, Nancy P.
Publisher: name: American Association for Cancer Research (AACR)
Year: 2020

description: Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by a paucity of tumor-proximal CD8+ T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8+ T-cell exclusion and resistance to immunotherapy are not well-known. Here, using a Kras- and p53-driven model of PDA, we describe a mechanism of action for the protumorigenic cytokine IL35 through STAT3 activation in CD8+ T cells. Distinct from its action on CD4+ T cells, IL35 signaling in gp130+CD8+ T cells activated the transcription factor STAT3, which antagonized intratumoral infiltration and effector function of CD8+ T cells via suppression of CXCR3, CCR5, and IFNγ expression. Inhibition of STAT3 signaling in tumor-educated CD8+ T cells improved PDA growth control upon adoptive transfer to tumor-bearing mice. We showed that activation of STAT3 in CD8+ T cells was driven by B cell– but not regulatory T cell–specific production of IL35. We also demonstrated that B cell–specific deletion of IL35 facilitated CD8+ T-cell activation independently of effector or regulatory CD4+ T cells and was sufficient to phenocopy therapeutic anti-IL35 blockade in overcoming resistance to anti–PD-1 immunotherapy. Finally, we identified a circulating IL35+ B-cell subset in patients with PDA and demonstrated that the presence of IL35+ cells predicted increased occurrence of phosphorylated (p)Stat3+CXCR3−CD8+ T cells in tumors and inversely correlated with a cytotoxic T-cell signature in patients. Together, these data identified B cell–mediated IL35/gp130/STAT3 signaling as an important direct link to CD8+ T-cell exclusion and immunotherapy resistance in PDA.
Quantum N-toroidal algebras and extended quantized GIM algebras of N-fold affinization
Creators: name: Gao, Yun
name: Jing, Naihuan
name: Xia, Limeng
name: Zhang, Honglian
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: We introduce the notion of quantum $N$-toroidal algebras as natural generalization of the quantum toroidal algebras as well as extended quantized GIM algebras of $N$-fold affinization. We show that the quantum $N$-toroidal algebras are quotients of the extended quantized GIM algebras of $N$-fold affinization, which generalizes a well-known result of Berman and Moody for Lie algebras.
description: 35 pages, 18 figures
Barriers and Perceived Usefulness of an ECHO Intervention for Office-Based Buprenorphine Treatment for Opioid use Disorder in North Carolina: A Qualitative Study
Creators: name: Green, Sherri L.
name: Shea, Christopher M.
name: Gertner, Alex K.
Publisher: name: SAGE Publications
Year: 2021

description: BACKGROUND: Medication treatment for opioid use disorder (M-OUD) is underutilized, despite research demonstrating its effectiveness in treating opioid use disorder (OUD). The UNC Extension for Community Healthcare Outcomes for Rural Primary Care Medication Assisted Treatment (UNC ECHO for MAT) project was designed to evaluate interventions for reducing barriers to delivery of M-OUD by rural primary care providers in North Carolina. A key element was tele-conferenced sessions based on the University of New Mexico Project ECHO model, comprised of case discussions and didactic presentations using a "hub and spoke" model, with expert team members at the hub site and community-based providers participating from their offices (i.e., spoke sites). Although federal funders have promoted use of the model, barriers for providers to participate in ECHO sessions are not well documented. Methods: UNC ECHO for MAT included ECHO sessions, provider-to-provider consultations, and practice coaching. We conducted 20 semi-structured interviews to assess perceived usefulness of the UNC ECHO for MAT intervention, barriers to participation in the intervention, and persistent barriers to prescribing M-OUD. Results: Participants were generally satisfied with ECHO sessions and provider-to-provider consultations; however, perceived value of practice support was less clear. Primary barriers to participating in ECHO sessions were timing and length of sessions. Participants recommended recording ECHO sessions for viewing later, and some thought incentives for either the practice or provider could facilitate participation. Providers who had participated in ECHO sessions valued the expertise on the expert team; the team's ability to develop a supportive, collegial environment; and the value of a community of providers interested in learning from each other, particularly through case discussions. Conclusions: Despite the perceived value of ECHO, barriers may prevent consistent participation. Also, barriers to M-OUD delivery remain, including some that ECHO alone cannot address, such as Medicaid and private-insurer policies and availability of psychosocial resources.
Additional file 1 of MsrR is a thiol-based oxidation-sensing regulator of the XRE family that modulates C. glutamicum oxidative stress resistance
Creators: name: Si, Meiru
name: Chen, Can
name: Zhong, Jingyi
name: Li, Xiaona
name: Liu, Yang
name: Su, Tao
name: Yang, Ge
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 1: Table S1. Bacterial strains and plasmids used in this study. Table S2. Primers used in this study. Figure S1. Multiple sequence alignment of MsrR with XREs from other organisms. Figure S2. Assays for the ncgl2679-ncgl2678-ncgl2677 co-transcription by reverse transcription PCR. Figure S3. Detailed genetic maps of the regulatory region of MsrR. Figure S4. 104-bp msrR transcript (from the translational start codon (GTG) of msrR gene to 104th nucleotide) was amplified from the remaining msrR ORF (Open Reading Frame) in ΔmsrR mutant with primers QmsrR-F and QmsrR-R. Figure S5. Negative regulation of msrR and mfs by MsrR. Figure S6. Reversible inhibition of the DNA binding activity of MsrR by H2O2 and role of Cysteine residue. Figure S7. Determination of the apparent KD values of MsrR and MsrR:C62S for PmsrR. Figure S8. Mutations in the predicted MsrR binding site derepressed the msrR expression. Figure S9. Oxidative stress-dependent structural changes of relevant MsrR in vivo.
Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers
Creators: name: Kamble, Prasad G.
name: Gustafsson, Stefan
name: Pereira, Maria J.
name: Lundkvist, Per
name: Cook, Naomi
name: Lind, Lars
name: Franks, Paul W.
name: Fall, Tove
name: Eriksson, Jan W.
name: Ingelsson, Erik
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Aim: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of genotype–phenotype relationships. Methods: We genotyped 2500 participants from the Swedish EpiHealth cohort and considered loss-of-function and missense variants in genes with relation to cardiometabolic traits as the basis for our GBR study. Therefore, we focused on carriers and non-carriers of the PPARG Pro12Ala (rs1801282) variant, as it is a relatively common variant with a minor allele frequency (MAF) of 0.14. It has also been shown to affect ligand binding and transcription, and carriage of the minor allele (Ala12) is associated with a reduced risk of type 2 diabetes. We re-invited 39 Pro12Pro, 34 Pro12Ala, and 30 Ala12Ala carriers and performed detailed anthropometric and serological assessments. Results: The participation rates in the GBR study were 31%, 44%, and 40%, and accordingly we included 12, 15, and 13 individuals with Pro12Pro, Pro12Ala, and Ala12Ala variants, respectively. There were no differences in anthropometric or metabolic variables among the different genotype groups. Conclusions: Our report highlights that from a practical perspective, GBR can be used to study genotype–phenotype relationships. This approach can prove to be a valuable tool for follow-up findings from large-scale genetic discovery studies by undertaking detailed phenotyping procedures that might not be feasible in large studies. However, our study also illustrates the need for a larger pool of genotyped or sequenced individuals to allow for selection of rare variants with larger effects that can be examined in a GBR study of the present size.
Additional file 1 of Conditional Dnmt3b deletion in hippocampal dCA1 impairs recognition memory
Creators: name: Kong, Qingnuan
name: Yu, Ming
name: Zhang, Meng
name: Wei, Chuang
name: Gu, Huating
name: Yu, Shaoyang
name: Sun, Wei
name: Li, Nan
name: Zhou, Yu
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1.
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00394
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00394, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00394, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1 of Global trends and gaps in research related to latent tuberculosis infection
Creators: name: Chaw, Liling
name: Chien, Lung-Chang
name: Wong, Justin
name: Takahashi, Ken
name: Koh, David
name: Lin, Ro-Ting
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
Aconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1
Creators: name: Wang, Yutao
name: Zhang, Huixiang
name: Wang, Jing
name: Yu, Ming
name: Zhang, Qianqian
name: Yan, Shan
name: You, Dingyun
name: Shi, Lanlan
name: Zhang, Lihuan
name: Wang, Limei
name: Wu, Hongxiang
name: Cao, Xue
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Current medicine for Alzheimer’s disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply Aconiti lateralis Radix Praeparata (Fuzi) may meet this goal. Analysing the anti-AD effect of Fuzi and its potential molecular mechanism. AD model cells were treated with Fuzi in 0-300 mg/mL for 24 h in 37 °C. The cell viability (CV) and length of cell projections (LCP) for each group were observed, analysed, and standardised using control as a baseline (CVs and LCPs). The Fuzi and AD relevant genes were identified basing on databases, and the molecular mechanism of Fuzi anti-AD was predicted by network analysis. Experiment results showed that Fuzi in 0.4 mg/mL boosted LCP (LCPs = 1.2533, p ≤ 0.05), and in 1.6–100 mg/mL increased CV (CVs from 1.1673 to 1.3321, p ≤ 0.05). Bioinformatics analysis found 17 Fuzi target genes (relevant scores ≥ 20), showing strong AD relevant signals (RMS_p ≤ 0.05, related scores ≥ 5), enriched in the pathways regulating axon growth, synaptic plasticity, cell survival, proliferation, apoptosis, and death (p ≤ 0.05). Especially, GRIN1 and MAPK1 interacted with APP protein and located in the key point of the “Alzheimer’s disease” pathway. These results suggest that Fuzi may have therapeutic and prevention potential in AD, and GRIN1 and MAPK1 may be the core of the pathways of the Fuzi anti-AD process. Fuzi should be studied more extensively, especially for the prevention of AD.
Sentence-level dialects identification in the greater China region
Creators: name: Xu, Fan
name: Wang, Mingwen
name: Li, Maoxi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Identifying the different varieties of the same language is more challenging than unrelated languages identification. In this paper, we propose an approach to discriminate language varieties or dialects of Mandarin Chinese for the Mainland China, Hong Kong, Taiwan, Macao, Malaysia and Singapore, a.k.a., the Greater China Region (GCR). When applied to the dialects identification of the GCR, we find that the commonly used character-level or word-level uni-gram feature is not very efficient since there exist several specific problems such as the ambiguity and context-dependent characteristic of words in the dialects of the GCR. To overcome these challenges, we use not only the general features like character-level n-gram, but also many new word-level features, including PMI-based and word alignment-based features. A series of evaluation results on both the news and open-domain dataset from Wikipedia show the effectiveness of the proposed approach.
description: 12
Biophysical characterisation of proteins and peptides
Creators: name: Morshed, Nabila
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The term biopharmaceuticals (otherwise known as biotechnological or biological products) was first introduced in the 1980s with the advent of the recombinant DNA technology and refers to proteins, polypeptides and their derivatives, which are produced from cell - culture expression systems. Unlike small molecules, which have a well - defined structure and can be chemically synthesized in large quantities and fully characterized, the manufacturing of biological products is highly complicated involving living cells, and therefore these products are required to be highly purified to meet the safety standards. Biological products have been developed as an effective treatment for patients who suffer from several immune system disorders, cancers, and blood - related diseases such as anemia. Biophysical characterization plays an important role in the development of biosimilars. Biophysical analytical techniques can monitor conformational similarity between batches of biosimilar products. Biophysical analysis aids in the characterization of biopharmaceutical drug candidates. Protein conformation, secondary structure, and folding play an important role in maintaining drug candidate potency and activity. The main goal of this research work is to establish the extent to which different spectroscopic techniques can be utilized to establish whether the same proteins and nucleic acids from different sources have the same structure.
Bedtoolsr: An R package for genomic data analysis and manipulation.
Creators: name: Phanstiel, Douglas H
name: Patwardhan, Mayura N
name: Davis, Eric S
name: Wenger, Craig D
Publisher: name: The Open Journal
Year: 2019

description: The sequencing of the human genome and subsequent advances in DNA sequencing technology have created a need for computational tools to analyze and manipulate genomic data sets. The bedtools software suite and the R programming language have emerged as indispensable tools for this purpose but have lacked integration. Here we describe bedtoolsr, an R package that provides simple and intuitive access to all bedtools functions from within the R programming environment. We provide several usability enhancements, support compatibility with past and future versions of bedtools, and include unit tests to ensure stability. bedtoolsr provides a user-focused, harmonious integration of the bedtools software suite with the R programming language that should be of great use to the genomics community.
Influence of surfactants on growth of individual aqueous coarse mode aerosol particles
Creators: name: Frossard, Amanda A.
name: Li, Wayne
name: Gérard, Violaine
name: Nozière, Barbara
name: Cohen, Ronald C.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Understanding the links between aerosol and cloud and radiative properties remains a large uncertainty in predicting Earth's changing energy budget. Surfactants are observed in ambient atmospheric aerosol particles, and their effect on cloud droplet growth is a mechanism that was, until recently, neglected in model calculations of particle activation and droplet growth. In this study, coarse mode aqueous aerosol particles were created containing the surfactant Igepal CA-630 and NaCl. The evaporation and condensation of these individual aqueous particles were investigated using an aerosol optical trap combined with Raman spectroscopy. For a relative humidity (RH) change from 70% to 80%, droplets containing both Igepal and NaCl at atmospheric concentrations exhibited on average more than 4% larger changes in droplet radii, compared to droplets containing NaCl only. This indicates enhanced water uptake in the presence of surfactants, but this result is unexpected based on the standard calculation of the effect of surfactants, using surface tension reduction and/or hygroscopicity changes, for particles of this size. One implication of these results is that in periods with increasing RH, surfactant-containing aqueous particles may grow larger than similarly sized aqueous NaCl particles without surfactants, thus shifting atmospheric particle size distributions, influencing particle growth, and affecting aerosol loading, visibility, and radiative forcing. Copyright © 2018 American Association for Aerosol Research
Additional file 2 of Global trends and gaps in research related to latent tuberculosis infection
Creators: name: Chaw, Liling
name: Chien, Lung-Chang
name: Wong, Justin
name: Takahashi, Ken
name: Koh, David
name: Lin, Ro-Ting
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2.
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis
Creators: name: Zhou, Yunfeng
name: Wang, Chunli
name: Kou, Jiejian
name: Wang, Minghui
name: Rong, Xuli
name: Pu, Xiaohui
name: Xie, Xinmei
name: Han, Guang
name: Pang, Xiaobin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury. Bianliang ziyu, a variety of Chrysanthemum morifolium Ramat. (Asteraceae), has potential hepatoprotective effect. However, the mechanism is not clear yet. To investigate the hepatoprotective activity and mechanism of Bianliang ziyu flower ethanol extract (BZE) on APAP-induced rats based on network pharmacology. Potential pathways of BZE were predicted by network pharmacology. Male Sprague-Dawley rats were pre-treated with BZE (110, 220 and 440 mg/kg, i.g.) for eight days, and then APAP (800 mg/kg, i.g.) was used to induce liver injury. After 24 h, serum and liver were collected for biochemical detection and western blot measurement. Network pharmacology indicated that liver-protective effect of BZE was associated with its antioxidant and anti-apoptotic efficacy. APAP-induced liver pathological change was alleviated, and elevated serum AST and ALT were reduced by BZE (440 mg/kg) (from 66.45 to 22.64 U/L and from 59.59 to 17.49 U/L, respectively). BZE (440 mg/kg) reduced the ROS to 65.50%, and upregulated SOD and GSH by 212.92% and 175.38%, respectively. In addition, BZE (440 mg/kg) increased levels of p-AMPK, p-GSK3β, HO-1 and NQO1, ranging from 1.66- to 10.29-fold compared to APAP group, and promoted nuclear translocation of Nrf2. BZE also inhibited apoptosis induced by APAP through the PI3K–Akt pathway and restored the ability of mitochondrial biogenesis. Our study demonstrated that BZE protected rats from APAP-induced liver injury through antioxidant and anti-apoptotic pathways, suggesting BZE could be further developed as a potential liver-protecting agent.
Gluon Tomography from Deeply Virtual Compton Scattering at Small-x
Creators: name: Hatta, Yoshitaka
name: Xiao, Bo-Wen
name: Yuan, Feng
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a full evaluation of the deeply virtual Compton scattering (DVCS) cross section in the dipole framework in the small-x region. The result features the $\cos ϕ$ and $\cos 2ϕ$ azimuthal angular correlations which have been missing in previous studies based on the dipole model. In particular, the $\cos 2ϕ$ term is generated by the elliptic gluon Wigner distribution whose measurement at the planned electron-ion collider (EIC) provides an important information about the gluon tomography at small-x. We also show the consistency with the standard collinear factorization approach based on the quark and gluon generalized parton distributions (GPDs).
description: 16 pages, 2 figures