cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Effect of Resource Quality on Partner Compensation in a Biparental Species
Creators: name: Murphy, Shane M
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Animal behaviour
Behavioural ecology

description: Sexual conflict arises in biparental species because of the fitness payoffs of shifting the costs of care onto their partner. The negotiation model asserts that parents actively monitor their partner’s level of investment and adjust their own in response generally resulting in partial compensation when a member of the pair reduces their level of investment. The willingness of one parent to compensate for the other’s change is found to be widely variable. Habitat or resource quality available to pairs may explain such variation. It is predicted that the level of compensation by one partner will increase with decreasing resource quality. I tested this prediction with the biparental burying beetle, Nicrophorus orbicollis. Under natural conditions, burying beetles apply costly social immune molecules to carcasses of small vertebrates to preserve nutritional value for young. The goals of this research were (1) to determine if males immunologically compensate when females are immunologically handicapped; and (2) determine the impact of resource quality on compensation. Changes in lysozyme-like-activity (LLA) and phenoloxidase (PO) production in oral and anal secretions were used to quantify social immune investment. Pairs were provided a mouse carcass of one of three qualities: freshly thawed, aged for 3 days, or aged for 7 days. As expected, female LLA decreased once injected with lipopolysaccharide (LPS) irrespective of carcass quality. Injections caused significant down regulation of oral PO in females. Male LLA increased as the quality of carcasses decreased when paired with handicapped females. Males showed no changes in PO across treatments or carcass types. My results demonstrate that males compensate for a change in maternal investment and the level of compensation increases as resource quality decreases.
sj-docx-1-cpc-10.1177_10556656211039871 - Supplemental material for Reading Development in Children With Nonsyndromic Cleft Palate With or Without Cleft Lip: Meta-analysis and Systematic Review
Creators: name: Lancaster, Hope Sparks
name: Lien, Kari M.
name: Haas, Jordan
name: Ellis, Paige
name: Scherer, Nancy J.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-cpc-10.1177_10556656211039871 for Reading Development in Children With Nonsyndromic Cleft Palate With or Without Cleft Lip: Meta-analysis and Systematic Review by Hope Sparks Lancaster, Kari M. Lien, Jordan Haas, Paige Ellis and Nancy J. Scherer in The Cleft Palate-Craniofacial Journal
Avian Influenza in the United States: A Threat to Food Safety and Public Health
Creators: name: Valquerizo, Pamela Cristina
Publisher: name: Zenodo
Year: 2024
Subjects: Avian Influenza
H5N1
Food Safety
Public Health
Biosecurity
One Health

description: Since early 2022, the United States has faced an unprecedented outbreak of Highly Pathogenic Avian Influenza (HPAI) A(H5N1), affecting poultry, dairy cattle, wild birds, and, in rare cases, humans. This paper explores the multifaceted implications of the epidemic for food safety and public health, drawing on the latest data from the U.S. Department of Agriculture (USDA), Food and Drug Administration (FDA), and Centers for Disease Control and Prevention (CDC) as of March 2025. With over 10,000 detections in wild birds across all 50 states, infections in more than 200 dairy herds, and 57 confirmed human cases, the outbreak presents serious challenges. This article analyzes risks to the food supply chain, evaluates current mitigation strategies such as pasteurization and biosecurity, and examines the socioeconomic toll on the agricultural sector. Preventive measures grounded in a One Health approach are proposed to mitigate future risks. This analysis underscores the urgency of coordinated action to safeguard both human health and food security.
IMPLEMENTING SUSTAINABLE TOURISM: THE CASE OF FAIR TOURISM IN SOUTH KOREA
Creators: name: Chung, Seungah
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Tourism management

description: While there is a concern that Sustainable Tourism has not been entirely adopted in practice (Graci, 2008), this thesis shows that Sustainable Tourism has been implemented by South Korean Tour Operators under the name of Fair Tourism. Fair Tourism is a rising trend as Sustainable Tourism in South Korea, and discussion on this new sector of the industry has increased in recent years (S. Gil Lee, 2016). This thesis adds to that discourse with three research objectives: 1) Define the concept of Fair Tourism. 2) What activities constitute Fair Tourism from practitioners’ viewpoint? 3) Examine how Fair Tour operators manage their sustainable supply chain based on the SCOR model.
To understand practitioners’ perception of Fair Tourism, this study has applied social constructionism, which recognized that human beings construct meanings through individual interaction (Walker, 2015). Semi-structured interviews with fifteen Fair Travel operators and thematic analysis have been applied for methodology (Elo & Kyngäs, 2008; McIntosh & Morse, 2015). This study has two significant findings. First, the findings have revealed a generally accepted definition of Fair Tourism by both researchers and operators. The definition includes Ensuring Economic Contribution to The Destination, Environmental and Social Sustainability, and Mutually Respectful Relationship. This generally acknowledged definition has helped Fair Tour operators develop the sector. Second, this thesis found that operators genuinely respect their suppliers. Operators regard their suppliers as partners who share responsibilities and benefits, leading to satisfactory outcomes for all partners (Macaulay et al., 1999). Their relationship with partners is long-term and deep rather than transactional.
Theoretically, this thesis contributed to the finding that Sustainable Tourism can be practicable under the name of Fair Tourism, demonstrating practitioners’ replies that are 100 percent consistent. This study applied a novel approach, focusing on the operators’ point of view, while previous studies on Fair Tourism focused on defining the term and the industry's demand (Byun, 2016; M.-K. Kim & Cho, 2019; Shin et al., 2018). Given that Supply Chain Operations Reference (SCOR) model has been developed for the analysis of the manufacturing industry, this study has advanced this manufacturing performance measurement framework and applied it to the tourism industry.
The Effect of Microbiomes on Food Crop yield and Quality in Aquaponic System
Creators: name: Wang, Yi-ju
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Horticultural production not elsewhere classified
Horticultural crop growth and development

description: Facing challenges for increasing demands for agricultural land, water, and energy, aquaponics has emerged as a sustainable solution that can contribute to global food production while minimizing environmental impacts. In a recirculating aquaponic system, the waste produced by aquatic animals is processed through microbes and breaks down into compounds for plant uptake. By recycling nutrients and water between hydroponics and aquaculture systems, aquaponics can reduce the waste of fish feeds and the use of chemical fertilizers and use 90-99% less water than conventional aquaculture. However, a few studies reported that nutrient use efficiency is still low in aquaponics, and only 10-37% and 20-30% of nitrogen (N) is typically assimilated by plants and fish, respectively. Yield reduction is commonly reported for plants in aquaponics. Due to the unique water physical and chemical environment, the microbiomes are more diverse in aquaponics than in hydroponics. While the most important microbial group is considered nitrifying bacteria, Nitrosomonas spp. and Nitrobacter spp. mediating the N conversion process from ammonia into nitrate, some plant growth-promoting bacteria (PGPB) in soils were found in aquaponics indicating their important function in the system. Meanwhile, the use of aquaculture wastewater can introduce and promote the growth of harmful microbial pathogens, posing a food safety concern. The goal of this research is to investigate the effects of microbiomes in aquaponic systems. A series of studies were conducted to examine the effects of different bacterial groups on food crop yield and quality and investigate the potential risk of contamination with enteric pathogens in aquaponic systems. The specific objectives are: to 1) examine whether enteric pathogens present in aquaponics and hydroponics; 2) investigate the effects of plant age and root damage on internalization of STEC E. coli in leafy vegetables and herbs. 3) examine the effects of pH on the plant yield in aquaponics; and 4) investigate the effects of PGPB on lettuce in aquaponics and hydroponics3. The data obtained from this research will fill the knowledge gap and provide new management strategies for cultivating crops in aquaponics, which will greatly promote the application of aquaponics to provide a solution for the increasing food demands in the future.
MicroRNAs expression profiling in Paget?s Disease of Bone, Osteoporosis and Hyperparathyroidism
Creators: name: BIANCIARDI, SIMONE
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Excluding monogenic bone disorders, it is now well established that in complex multifactorial diseases, with a recognized hereditary component, such as Paget?s disease of bone and osteoporosis, the associated genetic variants have a limited impact on gene expression and explain only a small fraction of the disease risk. Moreover, a larger proportion of variants associated to many human traits or diseases fall in loci which do not encode proteins, suggesting that additional mechanisms other than gene-gene and gene-environment interactions might be involved.
In this setting, we focus our attention on Paget?s disease of bone, osteoporosis, and hyperparathyroidism to clarify epigenetic mechanisms involved in their pathogenesis.
MicroRNAs (miRNAs) are small (?22 nt), noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and several biological processes. They contribute to every step of osteogenesis and bone homeostasis, from embryonic skeletal development to maintenance of adult bone tissue, by regulating the growth, differentiation, and activity of different cell systems inside and outside the skeleton. However, despite the rising number of experimental reports about this issue, our understanding of the exact mechanisms through which miRNAs are involved in the pathogenesis of Paget?s disease of bone, osteoporosis, and hyperparathyroidism remain unclear. For these reasons, we performed a miRNAs expression profiling in peripheric mononuclear cells (PBMCs) and serum of wild type pagetic patients (PDB-WT) and with mutations on the SQSTM1 gene (PDB-MUT) and osteoporotic subjects (OP) compared to healthy controls, using TaqMan Low Density MicroRNA Array Cards. After that, we performed the same analysis in serum of patients with hypercalcemic primary hyperparathyroidism and osteoporosis (H-PHPT) and normocalcemic primary hyperparathyroidism without osteoporosis (N-PHPT), compared to healthy controls. Differentially expressed miRNAs identified in PBMCs of pagetic and osteoporotic patients were then validated in single assay, while the validation of miRNAs identified in the serum of all subjects is ongoing. A bioinformatic analysis (Gene Ontology analysis) was performed to find putative functional pathways and biological processes linked to some differentially expressed miRNAs. These analyses identified numerous genes and pathways involved in regulation of osteoclasts, osteoblasts differentiation and bone metabolism in all the three pathologies considered. These results could be used not only to better understand new molecular mechanisms involved in Paget?s disease, osteoporosis, and hyperparathyroidism pathogenesis, but also as a resource of new biomarkers that could be introduced in the clinical practice as diagnostic tools.
Allele specific silencing by RNAi of R92Q and R173W mutations in cardiac troponin T
Creators: name: MIGLIORE, LOREDANA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Many familial forms of hypertrophic and dilated cardiomyopathy (HCM and DCM) are linked to autosomal dominant mutations in genes encoding sarcomeric proteins. Several efforts have been done to develop therapeutic approaches for these patients, including the design of Allele-Specific Silencing approaches by RNA interference (ASP-RNAi). ASP-RNAi represents a powerful and promising strategy to counteract genetic defects by using duplex small interfering RNAs (siRNAs) to target mutant alleles with minimal suppression of the corresponding wild-type allele. We focused on the R92Q and R173W missense mutations in the cardiac Troponin T gene (cTnT) associated to HCM and DCM, respectively and developed an ASP-RNAi strategy to specifically knock-down the mutant alleles. Following siRNA design and generation, the specific silencing of the mutant allele was tested by a luciferase reporter gene assay and further confirmed on HEK293T cells expressing either the wild type or mutant cTnT alleles. siRNAs fully complementary to the target sequence or containing single-base mismatches downstream the targeted mutations were analyzed and evaluated. Results obtained showed that optimal allele discrimination was obtained with the use of siRNA containing a single-base mismatch both for the R92Q and the R173W mutations.
Reusing Spent Laying Hens for Sustainable Agriculture
Creators: name: Valquerizo, Pamela Cristina
Publisher: name: Zenodo
Year: 2024
Subjects: subject: sustainable agriculture
subject: Animal Welfare
subject: laying hens
subject: Food waste
subject: Food Loss and Waste
subject: regenerative farming
subject: organic production
subject: circular economy
subject: Poultry/microbiology
subject: olive orchards

description: This article explores an innovative model that turns waste into value by reintroducing spent laying hens into sustainable agricultural systems. Originating in Portugal, this practice repurposes hens post-egg production to contribute to pest control, soil fertility, and food waste reduction—particularly within olive orchards. The model provides ecological, economic, and animal welfare benefits. This article examines its adaptation potential for U.S. agriculture, especially organic systems, and highlights logistical, regulatory, and environmental considerations for scalable implementation.

Author: Pamela Cristina Valquerizo, DVM.Veterinary Specialist in Food Safety and Animal Product Inspection.Member of IAFP and AFDO.Contact: pamela@foodsafeinspections.comWebsite: www.foodsafeinspections.com
Functionalization of Black Phosphorus with Inorganic Reagents
Creators: name: VANNI, MATTEO
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Since its first reported exfoliation in 2014, the interest in black phosphorus has grown dramatically. The direct band gap, the high carrier mobility and the large specific surface area of BP open up great opportunities in different topical sectors of physics and chemistry including catalysis. As each phosphorus atom in BP has an sp3 hybridization and is bearing a lone-pair, an effective approach to surface modification could encompass the coordination of transition metal fragments. In this thesis, the functionalization of exfoliated black phosphorus (2D BP) with different palladium precursors is presented. In particular, a new nanohybrid was obtained growing Pd NPs in situ on 2D BP. The new material, named Pd/BP, was characterized by means of different spectroscopic techniques and electron microscopy measurements. The existence of Pd?P bonds of 2.26(3) � between peripheral Pd atoms of the nanoparticles and BP flakes was revealed via EXAFS measurements, highlighting the ability of 2D BP to act as an effective ligand toward the surface of metal NPs. The nanohybrid Pd/BP was used successfully as heterogeneous catalyst in the liquid phase hydrogenation of chloronitrobenzene to chloroaniline, resulting extremely selective in the process. Remarkably, comparative studies carried out with Pd NPs supported on carbon as reference material, revealed that the use of BP as support is crucial to reach higher selectivity.
Following a distinct approach, the functionalization of 2D BP was accomplished by addition of the organometallic precursor [Pd(C3H5)Cl]2 to 2D BP. In-depth solid state characterization carried out by means of powder XRD and solid state 31P CP-MAS NMR allowed to unravel the nature of the new material. HAADF-STEM microscopy performed at atomic level was exploited to probe the morphology of the flakes, revealing the existence of a uniform distribution of the metal within 2D BP, with no formation of metal aggregates, such as Pd NPs. EXAFS measurements, together with DFT simulations, revealed the existence of unprecedented interlayer Pd?Pd dimers, bridging two BP layers. Consistently with morphological and structural analysis, testing the material (named Pd2/BP) in the benchmark hydrogenation of C=C and C?C bonds, the metal sites resulted inaccessible to organic substrates. Conversely, preliminary studies on the application of Pd2/BP in the hydrogen evolution reaction (HER) from acidic medium, pointed out a strong enhancement in electrocatalytic activity compared to pristine 2D BP.
Integral Closures of Ideals and Coefficient Ideals of Monomial Ideals
Creators: name: Hill, Lindsey P
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Other mathematical sciences not elsewhere classified

description: The integral closure $\overline{I}$ of an ideal $I$ in a ring $R$ consists of all elements $x \in R$ that are integral over $I$. If $R$ is an algebra over an infinite field $k$, one can define general elements of $I=\left( x_{1},\ldots,x_{n}\right)$ as $x_{\alpha}=\sum_{i=1}^{n}\alpha_{i}x_{i}$ with $(\alpha_{1},\ldots,\alpha_{n})$ belonging to a Zariski-open subset of $k^{n}$.
We prove that for any ideal $I$ of height at least $2$ in a local, equidimensional excellent algebra over a field of characteristic zero, the integral closure specializes with respect to a general element of $I$. That is, we show that $\overline{I}/(x)=\overline{I/(x)}$.
In a Noetherian local ring $(R,m)$ of dimension $d$, one has a sequence of ideals approximating the integral closure of $I$ for $I$ an $m$-primary ideal. The ideals \[ I \subseteq I_{\{d\}} \subseteq \cdots \subseteq I_{\{1\}} \subseteq I_{\{0\}}=\overline{I}\]are the coefficient ideals of $I$. The $i^{\text{th}}$ coefficient ideal $I_{\{i\}}$ of $I$ is the largest ideal containing $I$ and integral over $I$ for which the first $i+1$ Hilbert coefficients of $I$ and $I_{\{i\}}$ coincide.
With a goal of understanding how coefficient ideals behave under specialization by general elements, we turn to the case of monomial ideals in polynomial rings over a field. A consequence of the specialization of the integral closure is that the $i^{\text{th}}$ coefficient ideal specializes when the $i^{\text{th}}$ coefficient ideal coincides with the integral closure. To this end, we give a formula for first coefficient ideals of $m$-primary monomial ideals generated in one degree in $2$ variables in order to describe when $I_{\{1\}}=\overline{I}$. In the $2$-dimensional case, we characterize the behavior of all coefficient ideals with respect to specialization by general elements.
In the $d$-dimensional case for $d \geq 3$, we give a characterization of when $I_{\{1\}}=\overline{I}$ for $m$-primary monomial ideals generated in one degree. In the final chapter, we give an application to the core, by characterizing when $\core(I)=\adj(I^{d})$ for such ideals.
Ecological determinants of intertidal recruitment and metacommunity structure on the Atlantic coast of Nova Scotia
Creators: name: Scrosati, Ricardo A.
name: Ellrich, Julius A.
Publisher: name: F1000 Research Limited
Year: 2018

description: Rocky-intertidal species are often distributed as metacommunities along marine shores, as rocky habitats are patchy. Nearshore pelagic conditions often explain variation among the local communities, but most studies have been done on eastern ocean boundary coasts. We investigated potential drivers of intertidal metacommunity structure on the Atlantic coast of Nova Scotia. We studied the high intertidal zone of nine wave-exposed bedrock locations spanning 425 km of coastline. At each location in the spring, we measured the recruitment of barnacles and mussels, the two predominant sessile invertebrates. Satellite data on coastal phytoplankton abundance and particulate organic carbon (food supply for intertidal filter-feeders) and in-situ data on coastal seawater temperature explained to varying degrees the geographic structure of recruitment. In turn, the summer abundance of both filter-feeders was positively related to their spring recruitment. Ultimately, predator (dogwhelk) abundance increased with the recruitment and abundance of barnacles and mussels (the main prey of dogwhelks), suggesting that bottom-up forcing influences metacommunity structure on this coast. Sea ice constituted an overlapping source of variation. Drift ice leaving the Gulf of St. Lawrence in late winter disturbed intertidal communities in the northern locations, limiting local biodiversity compared with central and southern locations.
Supplemental Material, sj-pdf-1-arx-10.1177_17298814211042730 - Autonomous land vehicle path planning algorithm based on improved heuristic function of A-Star
Creators: name: Zhang, Jing
name: Wu, Jun
name: Shen, Xiao
name: Li, Yunsong
Publisher: name: SAGE Journals
Year: 2021
Subjects: Engineering not elsewhere classified

description: Supplemental Material, sj-pdf-1-arx-10.1177_17298814211042730 for Autonomous land vehicle path planning algorithm based on improved heuristic function of A-Star by Jing Zhang, Jun Wu, Xiao Shen and Yunsong Li in International Journal of Advanced Robotic Systems
Development of novel pyrazolo[3,4-d]pyrimidines as anticancer agents: synthesis of potent c-Src/Abl inhibitors
Creators: name: DI MARIA, SALVATORE
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: The interest in protein tyrosine kinases has increased in recent years, particularly since their
oncogenicity in human cells has been recognized. Tyrosine kinases promote phosphorylation of many
proteins involved in cellular signaling pathways and the deregulation of their normal activity leads to
diseases, such as cancer. In this context, several pyrazolo[3,4-d]pyrimidines have been developed as
Tyrosine Kinase Inhibitor (TKI) and some of them have revealed promising in vitro and in vivo
antitumor activity. In this thesis I describe the work done during my three years of PhD, which
concerns the design and synthesis of novel pyrazolo[3,4-d]pyrimidines able to inhibit the protein
tyrosine kinase c-Src and Abl, involved in cancer processes. The first chapter provides a general
introduction on Protein Kinases, focusing on the major non-receptor tyrosine kinases c-Src and Abl.
Here, the protein activation mechanisms and some structural aspects have been described. The second
chapter is dedicated to the development of potent c-Src/Abl inhibitors for the treatment of Chronic
Myeloid Leukemia (CML). Optimization of molecules, through the design and synthesis of novel
derivatives, has been successfully performed and new promising anticancer agents have been
obtained. The third chapter describes the elaboration of five novel families of pyrazolo[3,4-
d]pyrimidines designed through merge-hybridization with TKIs approved in cancer therapy. Thereby,
a small library of c-Src inhibitors against Hepatocellular Carcinoma (HCC) has been developed.
Finally, the last chapter illustrates the optimization process of two pyrazolo[3,4-d]pyrimidine
compounds, Si306 and Si409, with the aim of improving some pharmacological properties for the
treatment of Glioblastoma Multiforme (GBM) through the design and synthesis of a small set of
derivatives.
sj-pdf-1-cjk-10.1177_20543581211040332 – Supplemental material for Kidney Transplantation in Times of Covid-19: Decision Analysis in the Canadian Context
Creators: name: Yanev, Ivan
name: Gagnon, Michael
name: Cheng, Matthew P.
name: Paraskevas, Steven
name: Kumar, Deepali
name: Dragomir, Alice
name: Sapir-Pichhadze, Ruth
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-1-cjk-10.1177_20543581211040332 for Kidney Transplantation in Times of Covid-19: Decision Analysis in the Canadian Context by Ivan Yanev, Michael Gagnon, Matthew P. Cheng, Steven Paraskevas, Deepali Kumar, Alice Dragomir and Ruth Sapir-Pichhadze in Canadian Journal of Kidney Health and Disease
"It is of the nature of reason to regard things as necessary, not as contingent": A Defense of Spinoza's Necessitarianism
Creators: name: Rdzak, Brandon
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: History of philosophy
Philosophy not elsewhere classified

description: There is longstanding interpretive dispute between commentators over Spinoza’s commitment to necessitarianism, the doctrine that all things are metaphysically necessary and none are contingent. Those who affirm Spinoza’s commitment to the doctrine adhere to the necessitarian interpretation whereas those who deny it adhere to what I call the semi-necessitarian interpretation. As things stand, the disagreement between commentators appears to have reached an impasse. Notwithstanding, there seems to be no disagreement among commentators on the question of necessitarianism’s philosophical plausibility as a metaphysical view: the doctrine is wildly untenable. This consensus view is more relevant to the interpretive debate than few have recognized, since leading semi-necessitarian commentators take the doctrine’s alleged absurdity to be one of the most compelling reasons (if not the most compelling reason) to prefer their reading over the necessitarian interpretation: for, as a matter of methodological principle, great philosophers like Spinoza should not be ascribed ridiculous views in the absence of better evidence. This dissertation seeks to defend Spinoza’s commitment to necessitarianism on both the interpretive and philosophical fronts. I argue not only that the necessitarian interpretation of Spinoza is more plausible than the semi-necessitarian interpretation on textual grounds, but that Spinoza’s necessitarianism is a serviceable philosophical view whose tenability has been almost entirely overlooked and perfunctorily rejected. The principal basis upon which I build this defense is Spinoza’s rich and fascinating view of essences—what I simply refer to as his essentialism. Spinoza’s essentialism forms the bedrock of his metaphysics and is significant not least because it underlies and informs doctrines like his necessitarianism. Spinoza’s essentialism supplies resources to answer not just interpretive problems associated with necessitarianism, but philosophical challenges to the plausibility of the doctrine. My defense of Spinoza’s necessitarianism on philosophical grounds also offers a novel way of getting past much of the current interpretive impasse among commentators by effectively undercutting the methodological motivation for the semi-necessitarian reading. In addition to my defense on the interpretive front, then, my defense on the philosophical front provides supplementary reason to a fortiori favor the necessitarian reading of Spinoza.
sj-pdf-1-sri-10.1177_15533506211046100 – Supplemental Material for Hemostatic Efficacy and Biocompatibility Evaluation of a Novel Absorbable Porous Starch Hemostat
Creators: name: Zhu, Jianjun
name: Wu, Zhuona
name: Sun, Wenzhong
name: Meng, Zhiyun
name: Zhu, Xiaoxia
name: Gan, Hui
name: Gu, Ruolan
name: Guo, Xuan
name: Dou, Guifang
Publisher: name: SAGE Journals
Year: 2021
Subjects: Orthopaedics
Sports Medicine
Surgery
Engineering not elsewhere classified
Materials Engineering not elsewhere classified

description: Supplemental Material, sj-pdf-1-sri-10.1177_15533506211046100 for Hemostatic Efficacy and Biocompatibility Evaluation of a Novel Absorbable Porous Starch Hemostat by Jianjun Zhu, Zhuona Wu, Wenzhong Sun, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Xuan Guo and Guifang Dou in Surgical Innovation
sj-pdf-2-ejo-10.1177_11206721211044328 – Supplemental material for Cataract extraction and intraocular pressure-lowering agents delivery: A nationwide French study between 2005 and 2017
Creators: name: Chamard, Chloé
name: Huguet, Héléna
name: Bron, Alain M
name: Creuzot-Garcher, Catherine
name: Nogue, Erika
name: Villain, Max
name: Nagot, Nicolas
name: Carrière, Isabelle
name: Mura, Thibault
name: Daien, Vincent
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-2-ejo-10.1177_11206721211044328 for Cataract extraction and intraocular pressure-lowering agents delivery: A nationwide French study between 2005 and 2017 by Chloé Chamard, Héléna Huguet, Alain M Bron, Catherine Creuzot-Garcher, Erika Nogue, Max Villain, Nicolas Nagot, Isabelle Carrière, Thibault Mura and Vincent Daien in European Journal of Ophthalmology
Search for signal from self-annihilation of Dark Matter particles from the globular cluster M15 through MAGIC observations
Creators: name: BELLIZZI, LORENZO
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: In this PhD thesis I investigate on the presence of dark matter inside a peculiar globular cluster, M15 (also known NGC 7078), analysing the data collected by the MAGIC telescopes along 2015 and 2016 for a total of 170 hours of integrated observation.
M15 is one of the oldest object of the galaxy, located at 10.4 kpc from Earth and shows a very compact core, consequence of an initial phase of core collapse. It is likely that during this early phase the dark matter budget of M15 was concentrated inside the core.
First Whipple telescope and later the High Energy Stereoscopic System (H.E.S.S.) have studied M15 in the VHE ?-ray range but the instruments did not find any signal attributable to annihilating dark matter particles.
The MAGIC telescopes observed M15 in search for a VHE ?-ray excess due to pulsars. Data were collected for 173 hours and no significant excess was found. This same data set was then used in this work for a dark matter search in correlation with the new measurements on the density profile and mass to luminosity ratio in the inner parts of M15.
The expected signal is given by the astrophysical factor, J-factor, and the spectrum of particles emitted from annihilation. The spectrum depends by the annihilation model and I have chosen 100% branching ratio into different SM particle pairs. J-factor describes the dark matter distribution inside the source and I derived its value from optical measurements of the star velocities. An important contribution of this thesis was to provide a method for computing the uncertainty of the J-factor, based on Monte Carlo techniques.
No significant excess ?-ray signal from annihilating particles was found inthe MAGIC data set. I computed the upper limits on the cross-section as a function of several particles masses and for different channels of annihilation.
Assuming that the DM represents only 1% of the the total missing matter inside M15, the upper limits are computed. The results have the same order of magnitude of other upper limits whichwere computed during the observation of dwarf galaxies by MAGIC Telescopes and are few lower than limit of H.E.S.S..
CRISPR/Cpf1 and suicide gene as personalized approach for patients with TP53-mutated Chronic Lymphocytic Leukemia (CLL)
Creators: name: LORENZETTI, FLAMINIA CLELIA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Chronic Lymphocytic Leukemia (CLL) is a very heterogenous disease caused by alterations in both chromosomes and genes, such as deletion of the 13q14, 11q22-23, 17p12, and trisomy of chromosome 12 or genetic mutations in the TP53, ATM, BRIC3, NOTCH. Within genetic abnormalities, TP53 mutations are detected in a small percentage of leukemia patients (about 10%). Currently adopted therapeutic choices (chemoimmunotherapy, targeted therapy, hematopoietic stem cell transplantation) are not effective due to the acquired abilities of TP53-mutated clones to escape the control systems. For this reason CLL patients harboring a mutated TP53 gene (point mutation, insertion or deletions) are grouped in the highest risk category according to the international prognostic index for chronic lymphocytic leukemia (CLL-IPI). Hence, one possible solution for these patients would be the development of a personalized therapy.
In my study I designed and developed a CRISPR-Cpf1 system which has proved to be an efficacious technology to get rid of only mutated cancer cells. The system called CRISPR_LV_TK+, recently patented (WO2020/079574), is based on the locus specific delivery of the Herpes Simplex Virus ? Thymidine Kinase (HSV-TK) suicide gene in cells bearing the target TP53 mutation detected in a CLL patient (p.Ser183*) in follow-up in our Unit. The approach was positively tested in HEK293T cell lines engineered for the target mutation. Following administration of ganciclovir, I was able to detect a high percentage of cell death only in the samples that have properly integrated the HSV-TK. In conclusion, the results show the high efficiency and specificity of the CRISPR_LV_TK+ system, and opens avenues to be applied as personalized therapy not only for CLL but for different kinds of cancers caused by specific mutations in distinct genes which are the driver of therapy resistance.
RAQAMLI VA IJTIMOIY MEDIA MARKETING YORDAMIDA HAMKORLIKNI YO'LGA QO'YISH
Creators: name: Qodirov, Farrux
name: Rajabova, Dilbar
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada raqamli va ijtimoiy media marketing orqali hamkorlikni yo‘lga qo‘yishning samarali usullari tahlil qilinadi. Raqamli marketingning o‘sib borayotgan ahamiyati, ijtimoiy tarmoqlarning biznesdagi roli va brendlar o‘rtasida muvaffaqiyatli hamkorlikni shakllantirish bo‘yicha strategiyalar ko‘rib chiqiladi. Shuningdek, influencer marketing, kontent yaratish, maqsadli auditoriyani jalb qilish va marketing kampaniyalarining natijadorligini oshirish usullari yoritiladi. Maqola tadbirkorlar, marketing mutaxassislari va raqamli maydonda o‘z biznesini rivojlantirishni istaganlar uchun foydalidir.
IJTIMOIY TARMOQLARDAGI AXBOROTLARNI IDROK ETISH BORASIDA KOGNITIV YONDASHUVLAR TAHLILI
Creators: name: Jabbor, Alisher
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada ijtimoiy tarmoqlardagi axborotlarni o‘rganishda kognitiv yo‘nalishlarning o‘ziga xosligi va ularning foydalanuvchilar tomonidan axborotni qabul qilish va qayta ishlash jarayoniga ta'siri tahlil qilingan. Maqolada kognitiv yo'nalishlarning asosiy turlari, ularning salbiy oqibatlari va ta'sirini kamaytirish usullari ko'rib chiqilgan.
Implementation of a flexible Oxford Nanopore sequencing platform for microbial genomics
Creators: name: PINZAUTI, DAVID
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Oxford Nanopore sequencing technology is slowly revolutionising the entire microbiology
field. Its ease of use and cost effective approaches coupled with long reads sequencing
represent an essential and powerful tool. In the present thesis I have implemented a sequencing
platform based on the Oxford Nanopore technology, a flexible system suitable for both
research and diagnostic fields. The first part of my work was dedicated to the optimization of a
DNA extraction protocol capable of isolating high molecular weight (HMW) genomic DNA.
In fact, Nanopore sequencing readouts are highly influenced by both the quality and the
integrity of the genomic DNA. An enzymatic lysis based extraction protocol was optimized,
recovering HMW DNA from two strains of Streptococcus mitis and generating multiple ultra
long reads (i.e. >100 Kb in length), making it possible to achieve complete genome
assemblies. As the extraction protocol was mainly optimized for Gram-positive bacteria, it is
also suitable to lyse the thinner cell wall of Gram-negatives. Oxford Nanopore Whole Genome
Sequencing (WGS) approaches have enabled the complete genome sequencing and assembly
of 16 Enterococcus faecalis isolates from clinical dental samples. Sequencing data provided
enough information enabling i) population studies, defining genomic clusters based on isolates
homologies; ii) bacterial profiling, assessing antimicrobial resistance genes and virulence
traits; iii) comparative analysis, identifying genomic rearrangements and homologies based on
synteny blocks. Finally, the platform was used for the monitoring of the ongoing SARS-CoV-2
pandemic. We have proposed a 900 bp amplicon sequencing protocol, adapted from the
ARTIC sequencing protocol (https://artic.network/), enabling a near-complete genome
assembly of SARS-CoV-2 strains, helping in the detection of nucleotide changes and
monitoring the circulating viral lineages. In conclusion, the Oxford Nanopore sequencing
platform can bring several improvements in the microbiology field, allowing i) complete
genome assembly, ii) rapid microbial profiling, and iii) helping in the monitoring of local or
global outbreaks.
sj-pdf-3-jhi-10.1177_14604582211043920 – Supplemental material for An HL7 FHIR and GraphQL approach for interoperability between heterogeneous Electronic Health Record systems
Creators: name: Mukhiya, Suresh Kumar
name: Lamo, Yngve
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description: Supplemental material, sj-pdf-3-jhi-10.1177_14604582211043920 for An HL7 FHIR and GraphQL approach for interoperability between heterogeneous Electronic Health Record systems by Suresh Kumar Mukhiya and Yngve Lamo in Health Informatics Journal
sj-pdf-1-pss-10.1177_09567976211005702 – Supplemental material for Generating Options and Choosing Between Them Depend on Distinct Forms of Value Representation
Creators: name: Morris, Adam
name: Phillips, Jonathan
name: Huang, Karen
name: Cushman, Fiery
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-pdf-1-pss-10.1177_09567976211005702 for Generating Options and Choosing Between Them Depend on Distinct Forms of Value Representation by Adam Morris, Jonathan Phillips, Karen Huang and Fiery Cushman in Psychological Science
sj-pdf-1-ajs-10.1177_03635465211041087 – Supplemental material for Ability of Medial Patellofemoral Ligament Reconstruction to Overcome Lateral Patellar Motion in the Presence of Trochlear Flattening: A Cadaveric Biomechanical Study
Creators: name: Vinod, Amrit V.
name: Hollenberg, Alex M.
name: Kluczynski, Melissa A.
name: Marzo, John M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211041087 for Ability of Medial Patellofemoral Ligament Reconstruction to Overcome Lateral Patellar Motion in the Presence of Trochlear Flattening: A Cadaveric Biomechanical Study by Amrit V. Vinod, Alex M. Hollenberg, Melissa A. Kluczynski and John M. Marzo in The American Journal of Sports Medicine
sj-docx-1-cjk-10.1177_20543581211046079 – Supplemental material for Time in Therapeutic Range Using a Nomogram for Dose Adjustment of Warfarin in Patients on Hemodialysis With Atrial Fibrillation
Creators: name: Defoe, Kimberly
name: Wichart, Jenny
name: Leung, Kelvin
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-docx-1-cjk-10.1177_20543581211046079 for Time in Therapeutic Range Using a Nomogram for Dose Adjustment of Warfarin in Patients on Hemodialysis With Atrial Fibrillation by Kimberly Defoe, Jenny Wichart and Kelvin Leung in Canadian Journal of Kidney Health and Disease
"Females are not males: evolutionary strategies of the two sexes in chamois"
Creators: name: COTZA, ANTONELLA
Publisher: name: Universit� degli Studi di Siena
Year: 2020

description: Vincoli evolutivi, fisiologici, anatomici potrebbero determinare diverse risposte individuali a fattori di stress ambientali (e.g. fattori climatici, stagionalit� delle risorse), da parte di maschi e femmine. In ambienti montani, l'accesso a pascoli di alta qualit� per gli erbivori � limitato ai mesi primaverili-estivi, rendendo cos� l?alimentazione estiva cruciale per la sopravvivenza invernale, in particolare per le femmine, che devono affrontare i costi della maternit�, e per i nuovi nati. Nelle specie che vivono in gruppo, la stagionalit� delle risorse pu� influenzare anche il comportamento sociale: la diminuzione della disponibilit� e della qualit� di risorse alimentari pu� aumentare la competizione alimentare e i livelli di stress, portando a sua volta un aumento delle interazioni aggressive intraspecifiche.
La mia tesi riguarda un ungulato di montagna, il camoscio alpino. Ho studiato il comportamento riproduttivo e spaziale di maschi adulti, per i quali sono state descritte due tattiche riproduttive alternative (AMTs) (territorialit� e non territorialit�). Comprendere le differenze in aspetti importanti quali et�, successo di accoppiamento, aggressivit� e comportamento tra individui che adottano AMTs diverse aiuterebbe a spiegare la loro coesistenza nella popolazione. Ho analizzato dati raccolti su maschi individualmente riconoscibili durante 5 stagioni riproduttive (2011-2012, 2015-2017). Studiare come fattori ambientali e individuali influenzino le opportunit� riproduttive dei maschi territoriali aiuterebbe a capire come la territorialit� (una AMT) venga mantenuta nella popolazione. Ho considerato dati su comportamento riproduttivo di maschi territoriali e caratteristiche ambientali, registrati durante 5 stagioni riproduttive (2011-2012, 2015-2017). L'adozione di una AMT potrebbe influenzare l'uso dello spazio nei maschi. Al contrario, il comportamento spaziale femminile pu� essere influenzato dalla presenza delle prole. Ho studiato le differenze nell'uso dello spazio tra femmine, maschi territoriali e non territoriali (una differente AMT) (2011-2012-2017), usando radio-telemetria GPS-GSM. Sono stati inoltre valutati gli effetti di fattori meteorologici sul comportamento spaziale di entrambi i sessi. La variazione della frequenza delle interazioni aggressive intra-sessuali, della risposta endogena, della qualit� nutrizionale della dieta, nonch� la variazione delle dimensioni dei gruppi sono state studiate nelle femmine attraverso osservazioni comportamentali su individui riconoscibili e analisi di campioni fecali (Giugno-Novembre 2017-2018).
La continuit� del rapporto di lavoro nel Codice della crisi e dell?insolvenza
Creators: name: RENZI, SAMUELE
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: La tesi di dottorato ha tentato di far dialogare il nuovo diritto della crisi e dell?insolvenza, contenuto nel Codice di cui al d.lgs. 10 gennaio 2019, n. 14, con il vigente sistema di diritto del lavoro, fermando l?attenzione in modo particolare sulla continuit� aziendale e sulla continuit� del rapporto di lavoro.
sj-pdf-1-psw-10.1177_14789299211044868 – Supplemental material for Solar Panels and Political Attitudes
Creators: name: Umit, Resul
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, sj-pdf-1-psw-10.1177_14789299211044868 for Solar Panels and Political Attitudes by Resul Umit in Political Studies Review
title: Exercise and Effective Antitumor Immunosurveillance
title: Ejercicio Físico e Inmonivigilancia Antitumoral Efectiva
titleType: AlternativeTitle
Creators: name: del Campo Milán, Lara
Publisher: name: Zenodo
Year: 2025

description: Research Project Proposal (PI25/01101) for the Project call entitled Proyectos de Investigación en Salud. Modalidad Proyectos de Investigación en salud. Convocatoria 2025, from Ministerio de Ciencia e Innovación y Universidades. Instituto de Salud Carlos III.
DEVELOPMENT OF NOVEL LIQUID CHROMATOGRAPHY STATIONARY PHASES FOR IMPROVED CHARACTERIZATION OF BIOPHARMACEUTICALS
Creators: name: Schwartz, Cameron C
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Separation science

description: Monoclonal antibodies are large, complex biomolecules that can be difficult to characterize. Characterization is important because of the various post translational modifications that can occur during manufacturing, processing, and storage. Some modifications can lead to efficacy and safety issues and therefore are heavily monitored. A leading way to monitor various modifications is by using liquid chromatography. The high sensitivity, reproducibility, and ability to quantitate analytes makes it very attractive for monoclonal antibody characterization. The large molecular size of monoclonal antibodies (150 kDa) makes them challenging to separate efficiently and with high enough resolution to be helpful. New column technologies that would help improve protein separation efficiencies and slectivities would greatly help in this challenging process. In this thesis, three novel bonded phases are developed for the separation of monoclonal antibodies including a weak anion and cation exchanger (WAX, CEX) for the separation of charged species as well as a novel hydrophilic interaction chromatography (HILIC) for the separation of glycoforms. Column develop is achieved by optimizing selectivity and improving efficiency of separations by altering particle surface chemistry.
Supplemental Material, sj-pdf-1-arx-10.1177_17298814211044932 - Three-dimensional loading control of a pneumatic three-universal–prismatic–universal robot
Creators: name: Liu, Yu
name: Zhu, Qingling
name: Zhao, Guoxin
name: Ma, Shuchao
Publisher: name: SAGE Journals
Year: 2021
Subjects: Engineering not elsewhere classified

description: Supplemental Material, sj-pdf-1-arx-10.1177_17298814211044932 for Three-dimensional loading control of a pneumatic three-universal–prismatic–universal robot by Yu Liu, Qingling Zhu, Guoxin Zhao and Shuchao Ma in International Journal of Advanced Robotic Systems