cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
[Chers amis, Je vous remercie de vos lettres que je juge utiles]
Creators: name: Didier, Dacunha-Castelle
name: Dacunha-Castelle, Didier
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Comité de Liaison Scientifique et Universitaire Franco-cubain

description: Destinataire : Motta, Monsieur / Guerdoux, Jean
description: L’auteur de la lettre évoque : un malentendu concernant un article demandé sur la génétique à Cuba, des cours dispensés à Cuba, les relations de certains membres du Comité avec la Révolution cubaine, le développement du Comité, les problèmes de Cuba, les critiques faites sur certains du Comité, et son souhait de les voir devenir membres et participer activement aux activités en génétique ou au Bureau du Comité.
description: El autor de la carta evoca : un malentendido relativo a un artículo solicitado sobre la genética en Cuba, cursos impartidos en Cuba, las relaciones de algunos miembros del Comité con la Revolución cubana, el desarrollo del Comité, los problemas de Cuba, las críticas hechas a algunos del Comité, y su deseo de que se conviertan en miembros y participen activamente en las actividades de genética o en la Oficina del Comité.
description: Notes : Tampon en en-tête : Comité de Liaison Scientifique et Universitaire Franco-cubain.
description: Source: DDC-C-1969-10-27
description: Source: Localisation de la ressource : Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
Supplemental Materials for Comprehensive Understanding from Characterization of DBU-hydroxyl based ionic liquid for CO2 capture
Creators: name: Wilfred, Cecilia D.
name: Amat, Syarafana binti Ong Amat @
name: M Yunus, Normawati
Publisher: name: The Royal Society
Year: 2025
Subjects: classificationCode: 340199
subject: Analytical chemistry not elsewhere classified

description: TGA figure, table of density and refractive index, and graphs of second-order polynomial
iPSC Characterization
Creators: name: Cole, Hannah
Publisher: name: Zenodo
Year: 2023

description: iPSC generation has become increasingly easier because of advanced technology, but the characteristics of various iPSCs is depending on the source, derivation, passage and culture conditions. In order to evaluate the pluripotency, safety and confirm the identity of PSCs, it is essential to perform a set of characterization analysis. Our scientists with extensive experience at Creative Bioarray provide comprehensive iPSC characterization service for customers all over the world.
Biopharmaceutical Enzymes
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Enzymes are catalysts that, within the mild conditions of temperature, pH, and pressure of the cells, carry out chemical reactions at amazing high rate. They are characterized by a remarkable efficiency and specificity. Enzymes are classified into six categories according to the type of reaction catalyzed. They are oxidoreductases, transferases, hydrolases, lyases, ligases, and isomerases. Structurally, the vast majority of enzymes are proteins. Enzymes have been used in brewing, baking, and alcohol production, etc.
E.coli Surface Display
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: The chimeric protein of Lpp and OmpA is the most frequently used carrier for bacterial surface display in Escherichia coli, but arrays of other anchors or carriers have also been employed, including PhoE, OmpC, TraT, FhuA, or intimin. In addition, gram-negative bacteria also assemble complex structures at their surfaces, such as outer membrane lipoproteins, ice nucleation protein, flagella, pili or S-layers, all of which have been used for display. With rich experience, Creative Biogene could help you determine the best surface-anchoring motif according to the sizes of passengers. E.coli Surface Display
Systematic review and meta-analysis provide no guidance on management of asymptomatic bacteriuria within the first year after kidney transplantation
Creators: name: Medina-Polo, José
name: Falkensammer, Eva
name: Köves, Béla
name: Kranz, Jennifer
name: Tandogdu, Zafer
name: Tapia, Ana María
name: Cai, Tommaso
name: Wagenlehner, Florian
name: Schneidewind, Laila
name: Bjerklund Johansen, Truls Erik
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: (1) Background: Urinary tract infections (UTIs) are among the most frequent complications in kidney transplant (KT) recipients. Asymptomatic bacteriuria (ASB) may be a risk factor for UTIs and graft rejection. We aimed to evaluate available evidence regarding the benefit of screening and treatment of ASB within the first year after KT. (2) Evidence acquisition: A systematic literature search was conducted in MEDLINE, the Cochrane Library CENTRAL and Embase. Inclusion criteria were manuscripts in English addressing the management of ASB after KT. The PICO questions concerned Patients (adults receiving a KT), Intervention (screening, diagnosis and treatment of ASB), Control (screening and no antibiotic treatment) and Outcome (UTIs, sepsis, kidney failure and death). (3) Evidence synthesis: The systematic review identified 151 studies, and 16 full-text articles were evaluated. Seven were excluded because they did not evaluate the effect of treatment of ASB. There was no evidence for a higher incidence of lower UTIs, acute pyelonephritis, graft loss, or mortality in patients not treated with antibiotics for ASB. Analysis of comparative non-randomized and observational studies did not provide supplementary evidence to guide clinical recommendations. We believe this lack of evidence is due to confounding risk factors that are not being considered in the stratification of study patients.
PALOMERA D1.3 – Data Management Plan
Creators: name: Bandura- Morgan, Laura
name: Toth-Czifra, Erzsebet
name: Raciti, Marco
Publisher: name: Zenodo
Year: 2023
Subjects: Data management, PALOMERA, Horizon Europe, monograph, OA books, open access, open science, scholarly communication

description: The methodology that the PALOMERA project is designed upon is based on data collection and analysis around the political, economic, social, technological, legal, and environmental factors of Open Access (OA) book publishing. Data may vary from policy and framework documents to survey and interview transcripts. The methodology adopts a stakeholder-centric approach that is capable of capturing dimensions which will play a key part in understanding and supporting the progress of OA book policy and practice. The data collection process is guided by the goal of fulfilling these key dimensions by addressing issues in all ERAs countries, by collecting complex data that will cover all PESTLE factors, by considering all actors involved in OA book publishing at various stages of the research lifecycle.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
Effect of biochar, graphene, carbon nanotubes, and nanoparticles on microbial denitrification: A review
Creators: name: Li, Anhang
name: Yao, Jiachao
name: Li, Nan
name: Shi, Changjie
name: Bai, Mengwei
name: Wang, Zeyu
name: Hrynsphan, Dzmitry
name: Savitskaya, Tatsiana
name: Chen, Jun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Nitrogen pollution poses a substantial threat to water bodies, making the exploration of effective treatment technologies imperative. Among these, biological denitrification stands out as one of the most efficient methods. Various materials, including biochar, graphene, carbon nanotubes, and nanoparticles, have gained widespread use across different industries due to their unique properties. Numerous studies have investigated the impact of these materials on microbial denitrification individually, focusing on their influence on key enzymatic processes, functional genes, electron transport, functional proteins, and microbial metabolic activities. This manuscript aims to contribute a comprehensive and holistic perspective by presenting consolidated data on the collective impact of biochar, graphene, carbon nanotubes, and nanoparticles on microbial denitrification. The combination of biochar and microorganisms improves denitrification performance by 415%. Graphene increases enzyme activity (100–175.4%). The coupling of carbon nanotubes and microorganisms reduced denitrification performance by 57.42%. Nanoparticles reduce denitrification performance (73.4%), enzyme activity (63%), and electron transfer rate (52.4%) by entering the cell membrane. Moreover, these materials have been observed to induce alterations in the community structure of microorganisms involved in denitrification. The manuscript delves into the intricate details of how these materials influence the conformational changes of denitrifying enzymes, emphasizing the relationship between enzyme activity and structural modifications. Overall, this manuscript not only provides a thorough analysis of the effects of biochar, graphene, carbon nanotubes, and nanoparticles on microbial denitrification but also explores their implications for the conformational dynamics of denitrifying enzymes. Furthermore, it outlines avenues for future research, offering a roadmap to guide upcoming studies in this critical field.
Additional file 1: of Effects of definitive chemoradiation on circulating immunologic angiogenic cytokines in head and neck cancer patients
Creators: name: Vishwajith Sridharan
name: Margalit, Danielle
name: Lynch, Stephanie
name: Severgnini, Mariano
name: F. Hodi
name: Haddad, Robert
name: Tishler, Roy
name: Schoenfeld, Jonathan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Table S1. Associations between angiogenic cytokine levels at baseline and clinical parameters (Wilcoxon Rank Sum p-values for discrete; ANOVA p-values for continuous variables). Table S2. Angiogenic cytokine levels in patients treated with radiation without concurrent chemotherapy (pg/mL). Table S3. Correlation between angiogenic cyokines and immune cell populations (ANOVA significance values). Figure S1. Changes in cytokine levels in patients treated with radiation without concurrent chemotherapy. (DOCX 183 kb)
Schlussbericht und Handlungsempfehlungen zum Aufbau einer online Austauschplattform für Lehrpersonen
Creators: name: Dünner, Daniel
name: Raeber, Natalie
Publisher: name: Berner Fachhochschule, Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften (HAFL)
Year: 2024

description: Der vorliegende Bericht fasst die Erkenntnisse des Projekts «Schweizweiter online Wissensaustausch unter Lehrpersonen» zusammen, welches von 2020-2023 durchgeführt wurde. In dem Projekt ging es um die Möglichkeit des Austausches von Unterrichtsmaterialien via Online-Plattform. Wir blicken zurück auf die unterschiedlichen Phasen des Projekts und die darin gewonnen Erkenntnisse. Mit einer Literaturrecherche und verschiedenen Befragungen wurden die Basis für das Projekt gelegt. Die Resultate flossen in die Evaluation und das Design einer möglichen Plattform ein. Anschliessend wurde eine Plattform aufgebaut, im August 2022 eingeführt und nach einem Jahr evaluiert. Mit den Erfahrungen aus den Literaturrecherchen, den diversen Erhebungen und der Einführung der Plattform formulieren wir am Schluss im Kapitel 6 vierzehn Handlungsempfehlungen für Schulen und Bildungseinrichtungen, welche eine Austauschplattform für Lehrpersonen in einer ähnlichen Art aufbauen und betreiben wollen.
circRNA Research
Creators: name: Creative Biogene
Publisher: name: Zenodo
Year: 2023

description: circRNA is an emerging class of widespread, abundant and evolutionarily conserved noncoding RNA, and represents a research hotspot because of its close association with the development of diseases. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as a miRNA sponge, RNA binding protein sponge and translational regulator (Figure 1). In addition, due to the features of circRNAs including stability, conservation, high abundance and tissue/developmental stage-specific expression pattern, circRNAs are believed to be potential biomarkers for various diseases.
Dynamic manipulation of chiral domain wall spacing for advanced spintronic memory and logic devices
Creators: name: Jeon, Jae-Chun
name: Migliorini, Andrea
name: Fischer, Lukas
name: Yoon, Jiho
name: Parkin, Stuart S. P.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 530

description: Nanoscopic magnetic domain walls (DWs), via their absence or presence, enable highly interesting binary data bits. The current-controlled, high-speed, synchronous motion of sequences of chiral DWs in magnetic nanoconduits induced by current pulses makes possible high-performance spintronic memory and logic devices. The closer the spacing between neighboring DWs in an individual conduit or nanowire, the higher the data density of the device, but at the same time, the more difficult it is to read the bits. Here, we show how the DW spacing can be dynamically varied to facilitate reading for otherwise closely packed bits. In the first method, the current density is increased in portions of the conduit that, thereby, locally speeds up the DWs, decompressing them and making them easier to read. In the second method, a localized bias current is used to compress and decompress the DW spacing. Both of these methods are demonstrated experimentally and validated by micromagnetic simulations. DW compression and decompression rates as high as 88% are shown. These methods can increase the density with which DWs can be packed in future DW-based spintronic devices by more than an order of magnitude.
Aushandlung zwischen Peer-Kultur und regelkonformem Verhalten im Unterricht
Creators: name: Steiner, Cynthia Cristina
name: Chiapparini, Emanuela
Publisher: name: Verlag Barbara Budrich
Year: 2023

description: In der Entwicklung und Lebensgestaltung spielen Peerbeziehungen eine wichtige Rolle. Als Unterscheidungsmerkmal zur Schüler-Lehrerbeziehung, zeichnet sich die Beziehung zwischen Schüler*innen dadurch aus, dass sie auf Augenhöhe stattfindet und von Gleichheit, Gleichrangigkeit und Ebenbürtigkeit geprägt ist. Mit Peer Kultur oder Peergroups wird oft eine subjektive und sozial relevante Altersgleichheit angesprochen. In der deutschsprachigen Forschung ist es inzwischen üblich den englischen Begriff der Peers zu verwenden, wenn es um soziale Beziehungen zwischen Gleichaltrigen geht. Zudem wird Peer-Kultur als eine Beziehungsstruktur verstanden, welche Gleichaltrige miteinander teilen. Dabei kann die Peer-Kultur einerseits als eine Subkultur gesehen werden, die in ein schulisches, respektive gesellschaftliches Konstrukt eingebettet ist, andererseits aber auch als ein eigenständiger funktionierender Zusammenhang. Peer-Kulturen im Schulkontext unterscheiden sich von Peer-Kulturen in der Freizeit. Anhand von zwei ethnographische Transkriptionen befasst sich vorliegender Beitrag befasst mit dem Zusammenspiel zwischen der Peer-Kultur und der Schulkultur und geht der Frage nach, inwiefern sich diese gegenseitig beeinflussen und was die Momente auszeichnet, in denen sich die Peer-Kultur oder die Schulkultur zeigt.
Cyperus lupulinus Marcks
Creators: name: Info Flora
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Cyperaceae
Cyperus
Cyperus lupulinus

description: Cyperus lupulinus (Spreng.) Marcks
Sand-Zyperngras
Art ISFS: 130050 Checklist: 1014415 Cyperaceae Cyperus Cyperus lupulinus (Spreng.) Marcks
Bestimmungsschlüssel
ZusammenfassungKEINE ANGABE
Ökologie
Lebensraum Lebensraumnach Delarze & al. 2015
KEINE ANGABE
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Nomenklatur
Gültiger Name (Checklist 2017):Cyperus lupulinus(Spreng.) Marcks
Volksname Deutscher Name: Sand-Zyperngras Nom français: Souchet petit-houblon
Nome italiano: --
Übereinstimmung mit anderen Referenzwerken
RelationNomReferenzwerkeNo=Cyperus lupulinus (Spreng.) MarcksChecklist 2017130050
= Taxon stimmt mit akzeptiertem Taxon überein (Checklist 2017)  Taxon enthält (neben anderen) auch das akzeptierte Taxon (Checklist 2017)
Kommentare aus der Checklist 2017 Neues Taxon: Gegenüber SISF-2 neu aufgenommener Neophyt. Checklist
Status Indigenat: Neophyt: nach der Entdeckung von Amerika in der Region aufgetreten (nach 1500)
Liste der gefährdeten Pflanzen IUCN(nach Walter & Gillett 1997): Nein
description: Published as part of Info Flora, 2021,
PALOMERA D1.3 – Data Management Plan
Creators: name: Toth-Czifra, Erzsebet
name: Morgan, Laura Bandura-
Publisher: name: Zenodo
Year: 2023
Subjects: Data management, PALOMERA, Horizon Europe, monograph, OA books, open access, open science, scholarly communication

description: The methodology that the PALOMERA project is designed upon is based on data collection and analysis around the political, economic, social, technological, legal, and environmental factors of Open Access (OA) book publishing. Data may vary from policy and framework documents to survey and interview transcripts. The methodology adopts a stakeholder-centric approach that is capable of capturing dimensions which will play a key part in understanding and supporting the progress of OA book policy and practice. The data collection process is guided by the goal of fulfilling these key dimensions by addressing issues in all ERAs countries, by collecting complex data that will cover all PESTLE factors, by considering all actors involved in OA book publishing at various stages of the research lifecycle. Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them.
Full life cycle of uranium toward ore-soil-root-shoot system: A comprehensive review
Creators: name: Zheng, Shaojie
name: Guo, Di
name: Yang, Xuyuan
name: Liu, Yu
name: Liu, Shihao
name: Tian, Wenwen
name: Niu, Zhirui
name: Huang, Hua
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences

description: Uranium is a naturally occurring radionuclide with chemical toxicity, derived from deposits formed through complex processes. In recent years, uranium utilization activities have increased uranium levels in the soil environment, posing serious threats to soil quality, food safety, and human health. Phytoextraction of uranium contamination is currently a cutting-edge topic that has attracted significant attentions. To date, several studies have examined the behavior and impact of uranium in various aspects of its mineralization and "soil-plant" system. Accordingly, we focused on the full life cycle of uranium within the "ore-soil-root-shoot" system, based on published work from 2015 to 2024, to provide an updated review of significant research findings and theories. Here, we present the following key aspects: (i) the factors influencing uranium mineralization, including material sources, transport processes, and precipitation mechanism; (ii) both natural and anthropogenic sources that contribute uranium entry into the soil; (iii) uranium toxicity generated by its radio- and chemo-toxicities; (iv) the toxic effects of uranium and plant detoxification; (v) the internal mechanisms of uranium uptake and translocation by plant roots; and (vi) the role of transpiration in the transport of uranium from roots to the aboveground plant parts. Phytoextraction is an eco-friendly and efficient method for remediation of uranium-contaminated soils, and combined measures such as chelating agents’ application and microbial inoculation are effective to obtain the satisfying results. We also identify and summarize the gaps in current research, providing a reference for future related studies.
Discovery and anticancer screening of novel oxindole-based derivative bearing pyridyl group as potent and selective dual FLT3/CDK2 kinase inhibitor
Creators: name: Soudi, Aya
name: Bender, Onur
name: Celik, Ismail
name: El-Hafeez, Amer Ali Abd
name: Dogan, Rumeysa
name: Atalay, Arzu
name: Elkaeed, Eslam B.
name: Alsfouk, Aisha A.
name: Abdelhafez, Elshimaa M.
name: Aly, Omar M.
name: Sippl, Wolfgang
name: Ali, Taha F. S.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 615

description: Protein kinases regulate cellular activities and make up over 60% of oncoproteins and proto-oncoproteins. Among these kinases, FLT3 is a member of class III receptor tyrosine kinase family which is abundantly expressed in individuals with acute leukemia. Our previous oxindole-based hit has a particular affinity toward FLT3 (IC50 = 2.49 μM) and has demonstrated selectivity towards FLT3 ITD-mutated MV4-11 AML cells, with an IC50 of 4.3 μM. By utilizing the scaffold of the previous hit, sixteen new compounds were synthesized and screened against NCI-60 human cancer cell lines. This leads to the discovery of a potent antiproliferative compound, namely 5l, with an average GI50 value against leukemia and colon cancer subpanels equalling 3.39 and 5.97 µM, respectively. Screening against a specific set of 10 kinases that are associated with carcinogenesis indicates that compound 5l has a potent FLT3 inhibition (IC50 = 36.21 ± 1.07 nM). Remarkably, compound 5l was three times more effective as a CDK2 inhibitor (IC50 = 8.17 ± 0.32 nM) compared to sunitinib (IC50 = 27.90 ± 1.80 nM). Compound 5l was further analyzed by means of docking and molecular dynamics simulation for CDK2 and FLT3 active sites which provided a rational for the observed strong inhibition of kinases. These results suggest a novel structural scaffold candidate that simultaneously inhibits CDK2 and FLT3 and gives encouragement for further development as a potential therapeutic for leukemia and colon cancer.
Stable Knockout Cell Line Generation
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for genome editing. It has been widely used in current biology, functional genome screening, cell-based human hereditary disease modeling, epigenomic studies and visualization of cellular processes.
Exploring aromatic cage flexibility using cosolvent molecular dynamics simulations : an in-silico case study of tudor domains
Creators: name: Vorreiter, Christopher
name: Robaa, Dina
name: Sippl, Wolfgang
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 615

description: Cosolvent molecular dynamics (MD) simulations have proven to be powerful in silico tools to predict hotspots for binding regions on protein surfaces. In the current study, the method was adapted and applied to two Tudor domain-containing proteins, namely Spindlin1 (SPIN1) and survival motor neuron protein (SMN). Tudor domains are characterized by so-called aromatic cages that recognize methylated lysine residues of protein targets. In the study, the conformational transitions from closed to open aromatic cage conformations were investigated by performing MD simulations with cosolvents using six different probe molecules. It is shown that a trajectory clustering approach in combination with volume and atomic distance tracking allows a reasonable discrimination between open and closed aromatic cage conformations and the docking of inhibitors yields very good reproducibility with crystal structures. Cosolvent MDs are suitable to capture the flexibility of aromatic cages and thus represent a promising tool for the optimization of inhibitors.
Knockout Detection Kit
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Knockout Detection Kit provides a simple and highly effective method to detect gene knockout and gene polymorphism. The core component of the kit is the knockout detection enzyme, which has strong endonuclease activity and is homologous to Cel. The knockout detection enzyme can efficiently recognize and cleave the mismatches in heterogeneous DNA duplexes. Our knockout detection kit can be widely used for gene knockout detection in mammals, bacteria, fungi, virus and plants, especially applicable to screen positive clones and detect knockout efficiency using CRISPR/Cas9, TALENs or ZENs technologies.
Dissimilatory iron-reducing microorganisms: The phylogeny, physiology, applications and outlook
Creators: name: Zhao, Nanlan
name: Ding, Hao
name: Zhou, Xuji
name: Guillemot, Tom
name: Zhang, Zuotao
name: Zhou, Nan
name: Wang, Hui
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Dissimilatory iron reduction (DIR) is an important form of microbial respirations and a key part of iron biogeochemical cycle. A wide range of both bacteria and archaea that can conserve energy through Fe(III) reduction are called dissimilatory iron-reducing microorganisms (DIRMs). They have been increasingly recognized as important for coupling organic carbon oxidation in diverse anaerobic environments, such as soil, sediments, freshwater, marine water as well as extreme environments. In parallel with their phylogenetic diversity, DIRMs possess metabolic versatility, including multiple extracellular electron transfer (EET) pathways and various electron donors as well as acceptors. In this review, phylogenetic, environmental distribution of DIRMs was demonstrated comprehensively by summarizing 51 isolated DIRMs belonging to 27 genera in previous literature. EET mechanisms were further elaborated on based on four DIRMs representatives: Geobacter, Shewanella, Gram-positive bacteria and archaea. Various electron donors, acceptors, and novel metabolisms revealed recently prompt the development of DIRMs biotechnological applications, including bioleaching, bioremediation, biosynthesis, anaerobic fermentation, and production of bioelectricity. Although past decades have witnessed a great increase of the publications in DIRMs, further investigation are required for deep understanding and practical applications, such as their roles in natural environments, EET mechanisms in different DIRMs, cooperation with other microbes, and mechanisms of improved bioproduction by adding iron-oxides. DIRMs in real world. (1) they can be used for bioleaching; (2) they can be used for bioremediation for heavy metals and organic pollutants; (3) in aquatic environments, they can conduct iron reduction and form iron precipitate; (4) they can be used to produce current; (5) they can synthesize bioproducts; (6) they can form stable network with other soil microorganisms; (7) in various environments, they can form microbial iron cycle with iron-oxidizing microorganisms and influence many processes.
MiRNA Agomir
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene is a global leading agomir/ antagomir service provider for all passionate scientific researchers and our comprehensive synthesis service is supported by Cutting-Edge Chemical Synthesis Technology. MicroRNA Agomir/antagomir are members of a novel class of chemically engineered oligonucleotides.
Machining of semiconductors and dielectrics with ultra-short pulses: Influence of the wavelength and pulse bursts (Conference Presentation)
Creators: name: Neuenschwander, Beat
name: Jäggi, Beat
name: Remund, Stefan Marco
name: Zavedeev, E.
name: Pimenov, Sergei M.
Publisher: name: SPIE
Year: 2018

description: n the burst mode the reported removal rates were often higher than the ones achieved with single pulses at identical repetition rate and average power. But this effect is mainly caused by the reduced energy per single pulse in the burst and the corresponding fluence which is then nearer its optimum value showing highest specific removal rate. But there exist special situations where the burst mode shows a higher efficiency and therefore an increased specific removal rate. For copper e.g. it was found that a 3-pulse burst with a time spacing of 12 ns at a wavelength of 1064 nm leads to an about 15% higher specific removal rate. We extended the burst investigations to semiconductors and isolators and measured the specific removal rate as a function of the applied peak fluence for different materials, number of pulses in the burst and time spacing. For 1064nm silicon e.g. shows a maximum specific removal rate which amounts about 1.7µm3/µJ for single pulses and a 2 pulse burst as well. Then it almost linearly increases up to about 5 µm3/µJ when the number of pulses in the burst is raised to 8. A similar effect is found for machining grooves into diamond-like nanocomposite films with single pulses and a 2- and 3-pulse burst, respectively. In contrast, for silicon and 532 nm wavelength where the photon energy exceeds the bandgap, only a small difference in the maximum specific removal was observed. Heat accumulation is assumed to cause the higher specific removal rates but further experiments are needed gain a clearer picture.
Nutritional needs of adolescents who have been placed in a youth home under civil or criminal law : A contribution to health equity.
Creators: name: Stahel, Lea
name: Häfeli-Richner, Barbara
name: Haas, Karin
Publisher: name: Umschau-Zeitschriftenverlag
Year: 2019

description: Health inequity due to social circumstances is currently the subject of numerous health policy discussions throughout Europe. Young people who exhibit dissocial behavior are one of the population groups affected by health inequity. They are far more likely to exhibit characteristics of social disadvantage. Ensuring a satisfactory nutritional situation is a key factor in the physical and psychological health of these young people who are at a vulnerable stage of life in terms of their nutritional and physiological needs and their personal development. With the goal of making a contribution to health equity, this study investigated the nutritional needs of adolescents who have been placed in a cantonal youth home in Switzerland under civil or criminal law. The results show that a high level of participation in the planning and preparation of meals as well as the use of low-threshold oral communication platforms are important interventions for improving the quality of nutrition in this context and thus promoting health equity for young people living in the home.
Soziale Arbeit geht in die Schule : Kooperation im Rahmen von Ganztagesbildung
Creators: name: Chiapparini, Emanuela
name: Bussmann, Esther
name: Eberitzsch, Stefan
name: Stohler, Renate
Publisher: name: Avenir Social
Year: 2016
Subjects: 361: Sozialarbeit und Sozialhilfe
370: Bildung und Erziehung; Tagesschule
Kooperation
Ganztagsbildung
Soziale Arbeit
Elterngespräche
Betreuung
Schule
Inter- und Intraprofesselle Kooperation

description: Der Beitrag bietet einen Einblick in das für die Schweiz noch junge Handlungsfeld der Tagesschulen aus der Perspektive der Sozialen Arbeit. Dabei wird auf interne und externe Kooperationen von Ganztagesbildung und auf inter- als auch auf intraprofessionelle Kooperationen der Sozialen Arbeit fokussiert.
Automated non-sterile pharmacy compounding : a multi-site study in European hospital and community pharmacies with pediatric immediate release propranolol hydrochloride tablets
Creators: name: Sandler Topelius, Niklas
name: Stareprawo, Stephanie
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 615

description: Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is on the verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenting challenges in terms of consistency, dosage accuracy, quality control, contamination, and scalability. However, the emergence of cutting-edge technologies has paved a way for a new era for pharmacy compounding, promising to redefine the way medications are prepared and delivered as pharmacy-tailored personalized medicines. In this multi-site study, more than 30 hospitals and community pharmacies from eight countries in Europe utilized a novel automated dosing approach inspired by 3D printing for the compounding of non-sterile propranolol hydrochloride tablets. CuraBlend® excipient base, a GMP-manufactured excipient base (pharma-ink) intended for automated compounding applications, was used. A standardized study protocol to test the automated dosing of tablets with variable weights was performed in all participating pharmacies in four different iterative phases. Integrated quality control was performed with an in-process scale and NIR spectroscopy supported by HPLC content uniformity measurements. In total, 6088 propranolol tablets were produced at different locations during this study. It was shown that the dosing accuracy of the process increased from about 90% to 100% from Phase 1 to Phase 4 by making improvements to the formulation and the hardware solutions. The results indicate that through this automated and quality controlled compounding approach, extemporaneous pharmacy manufacturing can take a giant leap forward towards automation and digital manufacture of dosage forms in hospital pharmacies and compounding pharmacies.
Tree demographic strategies largely overlap across succession in Neotropical wet and dry forest communities
Creators: name: Schorn, Markus E.
name: Kambach, Stephan
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 580

description: Secondary tropical forests play an increasingly important role in carbon budgets and biodiversity conservation. Understanding successional trajectories is therefore imperative for guiding forest restoration and climate change mitigation efforts. Forest succession is driven by the demographic strategies—combinations of growth, mortality and recruitment rates—of the tree species in the community. However, our understanding of demographic diversity in tropical tree species stems almost exclusively from old-growth forests. Here, we assembled demographic information from repeated forest inventories along chronosequences in two wet (Costa Rica, Panama) and two dry (Mexico) Neotropical forests to assess whether the ranges of demographic strategies present in a community shift across succession. We calculated demographic rates for >500 tree species while controlling for canopy status to compare demographic diversity (i.e., the ranges of demographic strategies) in early successional (0–30 years), late successional (30–120 years) and old-growth forests using two-dimensional hypervolumes of pairs of demographic rates. Ranges of demographic strategies largely overlapped across successional stages, and early successional stages already covered the full spectrum of demographic strategies found in old-growth forests. An exception was a group of species characterized by exceptionally high mortality rates that was confined to early successional stages in the two wet forests. The range of demographic strategies did not expand with succession. Our results suggest that studies of long-term forest monitoring plots in old-growth forests, from which most of our current understanding of demographic strategies of tropical tree species is derived, are surprisingly representative of demographic diversity in general, but do not replace the need for further studies in secondary forests.
Custom Viral Service
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2023

description: Creative Biogene provides world-class packaging services for a variety of viral types using our QVirusTM platform. Creative Biogene's state-of-the-art facilities and highly experienced staff are available in order to assist in all areas of virus vector design and construction, as well as the generation of the virus in a quick turnaround. Our custom viral services are highlighted by a consistent high titer and large delivery viral counts.
Adenovirus Service
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Adenoviruses are a group of viruses that are non-enveloped, spherical and 80-110 nm in size.

The genome of adenovirus is a linear, non-segmented double-stranded (ds) DNA that is between 26000 and 48000 bp containing 22-46 protein-coding genes. The genes are divided into early phase (including E1, E2, E3, E4) and late phase (including L1, L2, L3, L4 and L5). Adenoviruses have a broad range of hosts and several adenoviral serotypes have been found, for example, there are 57 human adenovirus serotypes (HAdV-1 to 57) in seven species (Human adenovirus A to G).
Multi-omics and in-silico approach reveals AURKA, AURKB, and RSAD2 as therapeutic biomarkers in OSCC progression
Creators: name: Tasneem, Alvea
name: Singh, Manish
name: Singh, Prithvi
name: Dohare, Ravins
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Oral squamous cell carcinoma (OSCC), a prevalent form of head and neck cancer, poses a significant health challenge with limited improvements in patient outcomes over the years. Its development is influenced by a complex interplay of genetic alterations and environmental factors. While progress has been made in understanding the molecular mechanisms driving OSCC, pinpointing critical molecular markers and potential drug candidates has proven elusive. This study uniquely endeavors to conduct a meta-analysis to unveil therapeutic genes responsible for OSCC tumorigenesis. A multi-omics approach identified 951 differentially expressed genes (DEGs) associated with OSCC by analyzing microarray data from the NCBI GEO database. Weighted gene co-expression network analysis (WGCNA) detected a significant hub gene module comprising 805 genes, followed by the construction of protein-protein interaction network resulting in two small clusters of 7 gene-encoded proteins each. These clusters were filtered out based on top 10 significant pathways and gene ontology terms to identify six key target proteins with elevated expression levels, acting as potential therapeutic biomarkers for OSCC. Notably, RSAD2 emerged as a novel biomarker linked to OSCC progression. Furthermore, we identified potential inhibitors targeting AURKA, AURKB, and RSAD2 proteins and validated their interactions through molecular dynamics simulation studies. The simulations confirmed the stability of receptor-ligand complexes, suggesting ZINC03839281, ZINC04026167, and ZINC00718292 compounds hold promise as potential inhibitors for therapeutically targeting AURKA, AURKB, and RSAD2 as significant OSCC biomarkers. We recommend further comprehensive studies, including experimental and preclinical investigations, to validate the effectiveness of these lead compounds for OSCC treatment.
Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro : a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels
Creators: name: Zscherpe, Paula
name: Kalbitz, Jutta
name: Weber, Lisa
name: Paschke, Reinhard
name: Mäder, Karsten
name: Rechenberg, Brigitte
name: Cavalleri, Jessika
name: Meißner, Jessica
name: Klein, Karina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 615

description: Background: Gray horses are predisposed to equine malignant melanoma (EMM) with advancing age. Depending on the tumor’s location and size, they can cause severe problems (e.g., defaecation, urination, feeding). A feasible therapy for EMM has not yet been established and surgical excision can be difficult depending on the location of the melanoma. Thus, an effective and safe therapy is needed. Naturally occurring betulinic acid (BA), a pentacyclic triterpene and its synthetic derivate, NVX-207 (3-acetyl-betulinic acid-2-amino-3-hydroxy-2-hydroxymethyl-propanoate) are known for their cytotoxic properties against melanomas and other tumors and have already shown good safety and tolerability in vivo. In this study, BA and NVX-207 were tested for their permeation potential into equine skin in vitro in Franz-type diffusion cell (FDC) experiments after incubation of 5 min, 30 min and 24 h, aiming to use these formulations for prospective in vivo studies as a treatment for early melanoma stages. Potent permeation was defined as reaching or exceeding the half maximal inhibitory concentrations (IC50) of BA or NVX-207 for equine melanoma cells in equine skin samples. The active ingredients were either dissolved in a microemulsion (ME) or in a microemulsion gel (MEG). All of the formulations were transdermally applied but the oil-in-water microemulsion was administered with a novel oxygen flow-assisted (OFA) applicator (DERMADROP TDA). Results: All tested formulations exceeded the IC50 values for equine melanoma cells for BA and NVX-207 in equine skin samples, independently of the incubation time NVX-207 applied with the OFA applicator showed a significant time-dependent accumulation and depot-effect in the skin after 30 min and 24 h (P < 0.05). Conclusions: All tested substances showed promising results. Additionally, OFA administration showed a significant accumulation of NVX-207 after 30 min and 24 h of incubation. Further in vivo trials with OFA application are recommended.
Stable Cell Line Generation
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Creative Biogene offers high quality, fast turnaround and cost-effective Stable Cell Line Generation Service for protein expression, gene knockdown or genome editing that meet your specific research needs. Based on many years' experience on cell line development, Creative Biogene's cell culture scientists focus on optimizing all parameters specific to your cell lines to efficiently produce stable cell lines according to your requirements. Creative Biogene provides commercial and research cell line based on its proprietary expression vector, high throughput cell screening technologies and serum, animal components free process without any adaptation issue in a significantly reduced timeline.
How Sickness Absence and Presenteeism Influence Income: Empirical Evidence from the EWCS 2015
Creators: name: Pruschak, Gernot
Publisher: name: Springer
Year: 2021
Subjects: Sickness absence Presenteeism Employee health Productivity Income

description: Sickness absences possess severe impacts on company productivity. Existing research shows that firms also face productivity losses if employees show up at the workplace despite being sick, a phenomenon called presenteeism. This sparks the discussion of whether employees should stay at home and cure themselves or whether they should still turn up at the work-place. Using data from the European Working Conditions Survey 2015 we find that sickness absence and presenteeism relate positively to employees’ salaries. However, looking only at employees with wages depending upon the company performance, we show that those taking sick leaves possess lower incomes than those not taking sick leaves while no effects of presenteeism on income seem to exist. Based on our findings we advise employers to allow employees with health issues to telework from home as this might hinder the spreading of diseases but at the same time might keep productivity at higher levels.
Lipid Nanoparticles
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: RNA-based therapeutics are one of the most attractive classes of drugs for treating a variety of diseases. To function in vivo, RNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and RNA release. Lipid nanoparticles (LNPs) have been extensively studied as non-viral vectors for the delivery of RNA to target cells because of their relatively easy and scalable manufacturing processes.
Consumers’ attitudes and change of attitude toward 3D-printed food
Creators: name: Brunner, Thomas
name: Delley, Mathilde
name: Denkel, Christoph
Publisher: name: Elsevier
Year: 2018

description: 3D printing, also known as additive manufacturing, offers a wide range of new possibilities within the food industry. From the realisation of complex food designs to the automated preparation of personalised meals, 3D printers promise many innovations in the food manufacturing, retail and catering sectors. Because the successful launch of foods made using a novel technology needs to be accompanied by targeted communication, a careful assessment of consumers’ perception, needs and apprehensions is required. The present study aims to explore consumers’ attitude formation and evolution toward this technology and resulting food concepts. Data were collected through a postal survey sent out to a sample of 2047 German-speaking residents from Switzerland, yielding a final sample size of N = 260. Participants’ attitudes were assessed at the beginning and end of the survey. Three consecutive multiple regression analyses helped analyse the initial attitude, the final attitude and the attitude change determinants that were assessed. Participants’ self-assessment revealed a varied but overall relatively low initial knowledge level of 3D-printed food. Because the first impression has been proven to be decisive in attitude formation, this lack of knowledge allowed us to test the effect of targeted information, and we succeeded in overcoming food neophobia and convincing consumers that this technology can support them in the preparation of healthy and individualised meals while adding a playful dimension to food preparation. The information given, however, failed to overcome food technology neophobia. Avenues for the development and testing of adapted communication concepts are discussed.