cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
E. coli Fermentation for the Production of Sialic Acid
Creators: name: Zhi, Li
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: sialic acid
Escherichia coli
Feeding strategies

description: Sialic acid is the terminal sugar found on most glycoproteins and is crucial in determining serum half-life and immunogenicity on glycoproteins. The scarce supply of sialic acid hinders its advancement in basic research, diagnostic development and therapeutic production. In this work, the recombinant E. coli BRL04 (pBRL89) producing sialic acid was studied by some batch and fed batch runs of high cell density cultivation using a 3-L fermentor. Some cultivation conditions including carbon source, induction time, dissolved oxygen were optimized and different feeding strategies were compared to enhance sialic acid production. The results may be helpful to the further scale-up of sialic acid production and the production of other recombinant proteins by high cell density cultivation of E. coli.
Working with Transgendered People: Coworkers’ Gender Expectations, Conceptions and Behaviours in the Workplace
Creators: name: Falconi, Laurel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Gender Binary
Transgendered
Cis-gendered
Social Spaces
Bodies
The Workplace

description: Classification schemes are embedded into everyday life and people often expect that each category is fixed and stands alone from one another (Bowker & Star, 2000). In terms of gender, this is evident when people focus on gender as either male or female. With the increasing presence of people who are openly transgendered in the workplace (Taranowski, 2008), people’s expectations about gender as something ‘that just is’ are questioned. There is an emerging research literature focusing on people who transition in their work environments, but comparatively little on their coworkers. This research focuses on the experiences of the coworkers’ to examine how they interpret the meaning of gender after their colleague transitioned from being a “man” to being a “woman”. By analyzing and interpreting people’s behaviours in the context of a workplace where an individual reconstructs what it means to embody a specific gender identity, the feelings and behaviours that arise when expectations about gender are contradicted can be examined.
A real experience with a virtual learning guide instructional design
Creators: name: Calway, Bruce A.
Publisher: name: Swinburne
Year: 2024

description: At the Swinburne University of Technology, Lilydale (SUTL) campus, within the ITSM Discipline, I have collected all the elements for a virtual learning guide (VLG) and virtual lectures that take advantage of simple course development and delivery on an any-time, any-place basis. This paper firstly Research reports this success, the systems and survey results from the first three semesters of operation. While the technologies work well and are appreciated by significant numbers of students, the overall learning deficiencies and motivation of students mitigate against their efficacious use. The SUTL campus philosophy is tied to a constructivist paradigm of learner-centric, self-directed learning. However, this is not what I am observing. In fact, the opposite seems to be the case. Therefore, secondly I introduce in this paper research designed to investigate issues between technology and learning-centricity where these could be seen as a dichotomy between fully structured and agency based learner action. At some point students can move from a teaching-centric to a learning-centric paradigm and vis-a-vis. By analysing these relationships offers opportunity for SUTL campus to identify elements that mitigate in favour or against self-directed, learner-centric learning.
The Proliferation and Differentiation of Adult Neural Progenitors with a Novel Biomaterial
Creators: name: Coyle, Matthew J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013

description: Endogenous neural progenitor cells (NPCs) have the potential to repair the brain and spinal cord after injury. Using an in vitro neurosphere culture system we evaluated the ability of modifying adult rat spinal cord and subventricular zone progenitor cell differentiation into neurons, oligodendrocytes and astrocytes with retinoic acid, platelet derived growth factor and bone morphogenic protein-4, respectively. NPCs from both regions were exposed to varying concentrations of each factor. We found that SC and SVZ derived cells respond differently to these differentiation factors indicating that the therapeutic controls intended for one region may be different for the other. To assess delivery of potential therapeutic control, we evaluated a poly (lactide-co-glycolide) (PLGA) biomaterial designed to deliver these therapeutic agents to the injured central nervous system. The biocompatibility of PLGA for NPC proliferation, differentiation and survival was assessed using an in vitro neurosphere and differentiation assay. Our assessment of this biomaterial reveals that there were detrimental effects of PLGA degradation at later time points, suggesting, the need to control the degradation rate of this biomaterial, as its by-products -lactic acid and glycolic acid- may hinder the efficacy of delivered therapeutic factors to NPCs following injury.
Behaviour of Light-frame Wood Stud Walls Subjected to Blast Loading
Creators: name: Lacroix, Daniel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Blast loading
blast
Light-frame wood stud walls
high strain rate
single-degree-of-freedom
pressure
impulse
shock tube
partial composite action
Code considerations
full scale tests
Material predictive model

description: Deliberate and accidental explosions along with the heightened risk of loss of life and property damage during such events have highlighted the need for research in the behaviour of materials under high strain rates. Where an extensive body of research is available on steel and concrete structures, little to no details on how to address the design or retrofitting of wood structures subjected to a blast threat are available. Studies reported in the literature that focused on full scale light-frame wood structures did not quantify the increase in capacity due to the dynamic loading while the studies that did quantify the increase mostly stems from small clear specimens that are not representative of the behaviour of structural size members with defects. Tests on larger-scale specimens have mostly focused on the material properties and not the structural behaviour of subsystems. Advancements in design and construction techniques have greatly contributed to the emergence of taller and safer wood structures which increase potential for blast threat. This thesis presents results on the flexural behaviour of light-frame wood stud walls subjected to shock wave loading using the University of Ottawa shock tube. The emphasis is on the overall behaviour of the wall subsystem, especially the interaction between the sheathing and the studs through the nailed connection. The approach employed in this experimental program was holistic, where the specimens were investigated at the component and the subsystem levels. Twenty walls consisting of 38 mm x 140 mm machine stress-rated (MSR) studs spaced 406 mm on center and sheathed with two different types and sheathing thicknesses were tested to failure under static and dynamic loads. The experimental results were used to determine dynamic increase factors (DIFs) and a material predictive model was validated using experimental data. The implications of the code are also discussed and compared to the experimental data. Once validated, an equivalent single-degree-of-freedom (SDOF) model incorporating partial composite action was used to evaluate current analysis and design assumptions. The results showed that a shock tube can effectively be used to generate high strain-rate flexural response in wood members and that the material predictive model was found suitable to effectively predict the displacement resulting from shock wave loading. Furthermore, it was found that current analysis and design approaches overestimated the wall displacements.
title: Von COVID gezeichnet: so helfen unsere Ambulanzen bei lang anhaltenden Folgen
Creators: name: Zorn, Stefan
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 2
Development and Optimization of Novel Platforms for the Production of Recombinant Proteins
Creators: name: Potvin, Gabriel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Recombinant Proteins
Bioprocessing
Chlamydomonas reinhardtii
Pichia pastoris

description: As the worldwide demand for recombinant proteins and valuable metabolites continues to grow, and as the biological toolset at our disposal continues to expand, the development of novel, robust, and effective platforms for the production of these bioproducts represents an area of ever-increasing interest. Although many such bioprocesses are currently economically viable, many more, though holding considerable promise, remain uncompetitive. The development of novel, more productive systems increases the versatility and industrial applications of bioprocesses. The work described in this thesis explores several aspects of bioprocessing, both on the upstream side, concerned with the development of novel recombinant protein expression platforms or the isolation of novel genes with products possessing characteristics of interest, and on the downstream side, through the improvement of fermentation-based bioprocesses. Thirty-six homoplasmic recombinant strains of the microalga Chlamydomonas reinhardtii were developed having integrated genes for phytase or xylanase under the control of psbA and psbD promoters, codon optimized using novel algorithms, at two different genetic loci, in chloroplasts, to be used as novel animal feed additives. Enzyme production was characterized, and results, when compared to other published work in this field, may provide insight into the factors impacting recombinant protein production in microalgae. Using a “bio-prospecting approach”, the microflora of the digestive tract of a Canadian beaver was screened for cellulase-producing microorganisms. Although the screening approach did successfully identify a novel β-glucosidase gene from an isolated strain of Bacillus thuringiensis, the sequence was not significantly different from those already characterized. Two bioprocessing studies were performed to improve recombinant protein production in Pichia pastoris. In the first, the composition of standard Basal Salt Medium (BSM) was systematically optimized for the production of recombinant phytase, and the optimized media produced significantly more enzyme than the standard one, while also containing significantly reduced concentrations of KH2PO4 and MgSO4·7H2O (27.9 g/l and 4.8 g/l respectively), lowering the price of process inputs. The second was based on the screening of unconventional carbon sources for candidates that could sustain the growth and enzyme production using the same P. pastoris strain. Fructose and ethanol have shown to be viable alternatives to glucose or glycerol as sole carbon sources, and provide flexibility in terms of process design.
Integrin-linked Kinase Functions as a Cytoskeletal Scaffold in Oligodendrocyte Migration, Differentiation and Central Nervous System Myelination
Creators: name: O'Meara, Ryan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Myelin
Oligodendrocyte
Cell signaling
Development
Integrin-linked kinase
Cell biology

description: In the central nervous system (CNS), oligodendrocytes (OLs) generate myelin to facilitate the rapid propagation of neuronal impulses. In multiple sclerosis (MS), chronic demyelination leads to irreversible neurodegeneration that eventually impairs physical and cognitive function. Much effort is directed at elucidating the mechanisms underlying OL development in hope to unveil therapeutic targets for promoting remyelination in MS. Many aspects of OL biology are regulated by the integrins, a large family of transmembrane extracellular matrix (ECM) receptors. ECM components such as laminin and fibronectin bind to OL integrin receptors and initiate downstream signaling cascades involved in survival, proliferation, differentiation/myelination and migration. Integrin-linked kinase (ILK), an adaptor protein that binds to integrin cytosolic tails, works to stabilize the ECM-integrin connection by indirectly targeting the actin cytoskeleton to ECM adhesion sites. We hypothesized that ILK played an important role in OL migration, differentiation and capacity to myelinate neuronal projections. To address this hypothesis, we developed three cell culture techniques to assess these cellular phenomena in vitro. Conditional knockout of Ilk compromised both the morphological and molecular differentiation of primary mouse OLs in vitro, and reduced their capacity to produce myelin-like membrane. ILK was required for proper OL ensheathment of neuronal extensions when co-cultured with primary neurons. Conditional ablation of Ilk in vivo produced a transient amyelination defect that was endogenously compensated for at later time points. Loss of ILK in primary OLs was associated with upregulated RhoA signaling, and pharmacological inhibition of the RhoA axis restored the morphology of a distinct subset of NG2+ OPCs. ILK depletion in OL precursor cells (OPCs) resulted in a substrate-dependent defect in migration velocity and migration initiation. Inhibition of the RhoA signaling pathway enhanced the migratory velocity of wild-type OPCs, an effect that was dependent on ILK expression. In sum, we established three primary mouse OL cell culture techniques, with which we defined roles for ILK in OL biology. Our work highlights the importance of integrin signaling in OLs and provides new experimental methods useful in MS research.
Antiapoptotic Proteins in Human Macrophage Survival, Differentiation, Innate Immunity and Protection from HIV-induced Apoptosis
Creators: name: Busca, Aurelia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: apoptosis resistance
apoptosis
macrophages
HIV
HIV Vpr
IAPs
Bcl2
TLR signaling
IL-10
IL-27
MIG

description: Macrophages represent long lived immune cells that are remarkably resistant to apoptosis, which allows them to perform in highly stressful environments. Apoptosis resistance is a characteristic that develops during the differentiation process from monocytes to macrophages. However, the signaling pathways that mediate the development of macrophage antiapoptotic phenotype during differentiation remain mostly unknown. Because of their decreased susceptibility to cell death, macrophages are also key viral reservoirs during HIV infection. My research aims to understand the molecular mechanisms and signaling pathways that mediate cell survival during and after monocyte to macrophage differentiation and the involvement of the main families of antiapoptotic proteins, IAPs (inhibitors of apoptosis) and Bcl2 in this process. HIV accessory protein Vpr was used as an apoptotic stimulus, due to its death inducing abilities in other cell types. My results show that survival of macrophages is distinctively regulated during and after differentiation. I have identified a signaling pathway consisting of PI3K/Akt activation of NFκB that is important in survival of differentiating macrophages by specifically sustaining antiapoptotic Bcl-xL expression. However, once differentiated, Mcl-1, but not Bcl-xL is dependent on PI3K/Akt activation. Moreover, differentiated macrophages are resistant to the effect of HIV-Vpr, which is highly apoptotic for monocytes. In contrast, resistance to HIV-Vpr induced apoptosis of human macrophages is specifically mediated by antiapoptotic IAP proteins, with no involvement of the Bcl2 family, which maintains macrophage viability in the absence of any apoptotic stimuli. In addition to their antiapoptotic properties, IAPs are also important regulators of macrophage function. By using chemical compounds (SMAC mimetics) that target IAPs for degradation, I have shown that IAPs positively modulate LPS-induced IL10, IL-27 and MIG (monokine induced by IFNγ) production in human macrophages, by promoting TRAF2, JNK and p38 signaling and NFκB activation. In addition, IAPs also contribute to LPS-induction of CD80/CD86 costimulatory molecules. Overall, my results suggest that both IAPs and Bcl2 families contribute to survival of human macrophages and that IAPs are also involved in innate immune responses. Unraveling the mechanisms that control macrophage survival and function in various settings would provide therapeutic strategies aimed at eliminating cells when their survival is no longer beneficial for the host, as in the case of HIV infection or autoimmune diseases.
One Sound Bite at a Time: Examining the Discourse of the Representation of People Living with HIV/AIDS on an Entertainment-Education Drama RockPoint 256
Creators: name: Kawooya, Tina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: subject: HIV/AIDS
subject: People living with HIV/AIDS
subject: Uganda
subject: representation
subject: ideology
subject: radio
subject: Entertainment-Education
subject: identity
subject: stigma
subject: Cultural Studies
subject: FOS: Other humanities
subject: Discourse Analysis
subject: Critical Discourse Analysis
subject: Behavior Change Communication campaigns
subject: Young Empowered and Healthy (YEAH)
subject: RockPoint 256

description: The objective of this thesis is to examine the meaning of the language used in an Entertainment-Education (E-E) radio serial drama RockPoint 256 (RP256) and its representation of People Living with HIV/AIDS (PLHA) and HIV/AIDS. The theoretical framework that is used to guide this study is the Cultural Studies perspective. Using Cultural Studies is instrumental to a study such as this that looks to find the source of meaning in RP256’s discourse (Hall, 1993, 105). The methodological research design used is discourse analysis that examines the oral and written data of RP256. Discourse analysis “focuses on the way language is used, what it is used for, and the social context in which it is used” (Punch, 1998, 226). There were two types of discourse analyses used. Gee’s (1999) discourse analysis is used to analyse the linguistic nature of the texts at a micro level while, Fairclough’s (1989) discourse analysis is used to observe the overarching meaning of the discourse found in RP256 at the macro level. The analysis of the data indicates that the representation of PLHA is a product of the societal and cultural markers that are a result of ideological labels given to HIV/AIDS and PLHA. The study concludes that PLHA are ostracised, stigmatized, live in poverty and are mostly women. The societal and cultural markers indicate that HIV/AIDS is still viewed as a plague and as a result PLHA are often silenced, marginalized, and discriminated against in Uganda.
Effect of Salt on Biodegradation of Model Alkanes and Crude Oil Saturates by Hydrocarbon-degrading Bacteria
Creators: name: Feng, Yuchi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Salt
Biodegradation
Alkanes
Crude oil

description: Crude oil leakages often give rise to in situ contamination with both oil and salt. In this study, the biodegradation of model alkanes and of saturated hydrocarbons in whole crude oil by hydrocarbon-degrading bacteria was investigated at different salt (NaCl, KCl, Na2SO4) concentrations. Changes in cell surface hydrophobicity at different NaCl concentrations were also investigated. The results show that with increasing NaCl concentration, the lag phase for strain growth on hydrocarbons was prolonged; however, the total degradation efficiency was not influenced greatly. The formation of different sizes of cell aggregates at different salt concentrations indicated that salt could indirectly influence mass transfer of hydrocarbons from the medium to the interior of the cells. The results also showed that KCl had a less inhibitory effect on biodegradation than NaCl, and changes of Na2SO4 concentration did not greatly affect biodegradation. In addition, cell surface hydrophobicity increased with increasing NaCl concentration when the cultures were grown on hydrocarbons.
title: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie 06/23
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie, vol. 2023, no. 06
Hume's Functionalistic Theory of the Self
Creators: name: Hosseini, Sardar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Hume
Functionalism
Self
Personal Identity

description: The main claim of this dissertation is that Hume’s theory of the self can be interpreted in terms of a causal or functional theory of mind. It is a thesis about Hume’s identification of mental particulars―impressions and ideas―in terms of the kind of roles that each plays in the cognitive system that it is a member of. The true Humean idea of the human mind is to understand it as a system of different mental states and processes, which are linked together by the relation of cause and effect. Functionalism as such can be construed as both teleo-functionalism and psycho-functionalism. The former is rooted in his teleological characterization of the mind according to which the bundle of perceptions persists over time by maintaining functional continuity, whereas the main source of Hume’s psycho-functionalism lies in his Representational Theory of Mind. Hume, however, Hume expresses his strong dissatisfaction with his earlier treatment of the topic, and confesses that he now finds an inconsistency in his original account. He does not make clear in his recantation what he finds problematic in his earlier account. And although more than a dozen interpretations have been suggested, no consensus as to what Hume’s worry is has emerged. I claim that Hume’s functionalism, as presented in the main body of the Treatise, stores a problem for him and when he arrives at the Appendix he realises the problem and confesses that he is unable to resolve it. The problem that leads to the inconsistency has two main possible sources: First, the principles of constancy and coherence may successfully account for the arising belief in the idea of the continued and distinct existence of external objects and the idea of personal identity, but they fail to explain our belief in other minds (selves). Second, Hume’s functionalism is circular because it presupposes personal identity. The central idea is that if Hume is right to say that something like functional continuity would suffice for persons to persist through time, then he must show that we can have a complete account of how one’s mental states produce the idea of a persisting self without making assumption about the identity condition of their subject or bearer. And of course, psycho-functionalism, including Hume’s, identifies a mental state in terms of its functional relations to other mental states that are the states of the same person. This is straightforwardly circular.
L’efficacité personnelle en présence de douleur chronique comme médiateur de la relation entre l’attachement amoureux non-sécurisant, le fonctionnement individuel et la satisfaction conjugale
Creators: name: Martel, Marie-Eve
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: douleur chronique
attachement amoureux
efficacité personnelle face à la douleur
fonctionnement individuel
satisfaction conjugale

description: L’efficacité personnelle face à la douleur a été examiné comme médiateur de la relation entre l’attachement amoureux non sécurisant d’une personne (anxiété face à l’abandon et évitement de l’intimité) et le fonctionnement individuel, ainsi que pour la relation entre l’attachement amoureux non sécurisant et la satisfaction conjugale. L’échantillon comprenait 45 adultes qui vivent quotidiennement avec de la douleur chronique et qui sont en relation de couple depuis au moins 6 mois. Les résultats indiquent que l’efficacité personnelle face à la douleur est un médiateur de la relation entre l’anxiété face à l’abandon et le fonctionnement individuel. Les résultats démontrent également des liens directs entre l’efficacité personnelle face à la douleur et le fonctionnement individuel, entre l’évitement de l’intimité et un faible fonctionnement individuel, et entre les deux dimensions de l’attachement non sécurisant (anxiété et évitement) et une faible satisfaction conjugale.
A grounded theory of the leadership process in a large government bureaucracy
Creators: name: Kriflik, G. K.
name: Jones, Robert
Publisher: name: Swinburne
Year: 2024

description: This paper presents a theory of the leadership process within the particular substantive setting of a large government bureaucracy. The study organisation (labelled AGRO) possesses a dominant engineering culture and has a history characterised by non- tumultuous change. The research methodology of orthodox grounded theory was employed. The main concern of the participants was found to be a desire to close the gap between their current work reality and that level they perceived themselves to be capable of achieving. This was resolved through the basic social process of Minimising Attainment Deficit. Leadership aspects of charisma and vision where not evident in this substantive setting.
Wind Uplift Resistance of Roof Edge Components
Creators: name: Alassafin, Wassim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: wind
roof
roof edge
flashing
coping
cleat
dynamic testing
failure mode
edge component

description: A roof is a critical envelope of a building. It provides protection for the building interior against various weather elements, such as snow, rain and wind. Roofs are normally composed of several components such as insulation, barriers and water proofing membrane. A roof edge is the perimetric part of a roof that serves as termination for roof components. In generic terms, a roof edge system is composed of a parapet with metal components, such as coping and cleat/clip. The edge system is typically subjected to negative pressure (suction) due to wind flow over the roof. Therefore, a roof edge is the front-line of defence against wind action. To develop testing standards and design guidelines for roof edges, a project referred as REST (Roof Edge Systems and Technologies) has been initiated in cooperation with the NSERC (Natural Sciences and Engineering Research Council). For the REST project, this thesis contributes in two folds: wind design procedure and the development of an experimental method for testing roof edge components. The present thesis analyzes the wind load calculation procedures as per the National Building Code of Canada (NBCC) and American Society of Civil Engineers (ASCE). This has been achieved by taking side-by-side cities along Canada-USA border; wind load calculations were performed to demonstrate the differences and similarities between the NBCC and ASCE. As a part of the current contribution, the existing version of the online Wind-RCI Calculator was updated from NBCC2005 to NBCC2010 provisions. Towards the experimental contribution, the current study presents a new experimental method for testing and evaluating wind uplift resistance of roof edge systems by simulating wind loads in a lab environment on full-scale mock-ups. The test apparatus had a gust simulator device to mimic wind gusting (dynamic loading). This research investigates three widely used edge systems in North America: Continuous Cleat Configuration (CCC), Discontinuous Cleat Configuration (DCC) and Anchor Clip Configuration (ACC). Preliminary data show that CCC edge system has higher resistance in comparison to DCC and ACC edge systems. The experiments also revealed the need for experimental setup enhancement. Additional investigations by using the enhanced experimental setup were performed on both CCC and DCC edge systems.
What to Do When Privacy Is Gone
Creators: name: Brusseau, James
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Today's ethics of privacy is largely dedicated to defending personal information from big data technologies. This essay goes in the other direction. It considers the struggle to be lost, and explores two strategies for living after privacy is gone. First, total exposure embraces privacy's decline, and then contributes to the process with transparency. All personal information is shared without reservation. The resulting ethics is explored through a big data version of Robert Nozick's Experience Machine thought experiment. Second, transient existence responds to privacy's loss by ceaselessly generating new personal identities, which translates into constantly producing temporarily unviolated private information. The ethics is explored through Gilles Deleuze's metaphysics of difference applied in linguistic terms to the formation of the self. Comparing the exposure and transience alternatives leads to the conclusion that today's big data reality splits the traditional ethical link between authenticity and freedom. Exposure provides authenticity, but negates human freedom. Transience provides freedom, but disdains authenticity.
Alcuni suggerimenti omeopatici contro lo stress del traduttore di poesia
Homeopathic tips for a stressed-out poetry translator
Creators: name: Nasi, Franco; Università Di Modena E Reggio
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Traduzioni; Poesia; Passioni del traduttore; ddomesticamento traduttivo; Compensazioni
Translation; Poetry; Translator's passions; Translation domestication; Compensation.

description: Il traduttore di poesia si trova spesso di fronte a testi difficili, quasi impossibili da tradurre. Il senso di inadeguatezza che il traduttore avveduto, modesto e sensibile prova (o dovrebbe provare) di fronte ai testi poetici, lo spinge a constatare  il limite delle proprie capacità “poetiche” di fronte alla compattezza e alla forza del testo originale, oltre che alle oggettive e a volte incolmabili differenze fra le lingue e le culture coinvolte nel processo di traduzione. Da qui l’insorgere di uno stato di sconforto, di abbattimento, di malinconica impotenza. Nell’intervento si tenta, fra digressioni, incursioni sul tema e terapie traduttive omeopatiche, di dare alcuni consigli ai traduttori di poesia, movendo da alcune considerazioni sulla versione in italiano di due testi di autori americani: e.e. cummings e Billy Collins. Il primo presenta particolari difficoltà traduttive per le scelte lessicali ambigue e per la composizione grafica del testo, il secondo per la specificità e la pregnanza culturale delle immagini e dei tropi.  Billy Collins poi, in un gioco di specchi, si presta  a ritradurre “culturalmente” in inglese, la versione italiana.
description: Quite often a translator of poetry has to deal with difficult texts, which appear almost impossible to translate. A careful, modest and sensitive translator feels (or should feel) a sense of inadequacy when facing this kind of poems. This feeling leads him to a clear awareness of the limits of his "poetic" power, and of the objective and sometimes unbridgeable differences between the languages ​​and cultures involved in the translation process. The upshot is a state of despair, dejection, or melancholic impotence. Moving among digressions, hints for translation therapies and homeopathic remedies, the essay tries to offer a bit of advice to literary translators. It deals specifically with the Italian versions of two texts composed by the American poets e.e. cummings and Billy Collins. The first is characterized by the ambiguous choice of words and its graphic composition; the second by the specificity and cultural importance of its images and figures. Billy Collins then, as in a hall of mirrors, retranslates a second “cultural” Italian version in English.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
Visualità e lettura. Dinamiche psicologiche e percettive degli ambienti di lettura (dalla pagina stampata agli ipertesti visivi)
Visuality and reading. Psychological and perceptive dynamics of reading environments (from the printed page to the visual hypertext)
Creators: name: Petrelli, Micla; Accademia Di Belle Arti Di Urbino
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Percezione del lettore; Parola; Immagine; E-book; Visione alfabetica; Luce.
Perception of the reader; Word; Image; E-book; Alphabetical vision; Light.

description: Questo saggio indaga gli aspetti psicologici e percettivi della lettura come fatto visuale e ne osserva il funzionamento all'interno di diversi ambienti: dalla tradizionale pagina stampata alla più recente pagina elettronica dell'e-book, con una particolare attenzione riservata alla relazione tra “parola” (gli aspetti linguistici  a carico della visione alfabetica) e “immagine” (immagine della parola e immagine con la parola - gli ipertesti visivi integrati ai testi verbali nel libro elettronico). Alla luce degli studi della psicologia della percezione, della neurofisiologia e della fenomenologia, l’esperienza della lettura è funzione che trascende quei sistemi di valori che tendono ad opporre le categorie di verbale e visivo, intelletto e intuizione, logos e disordine. Ma è la letteratura a mostrarci ancor meglio l’inviolabilità dell’appartenenza di parola e immagine, e come il pensare per immagini consista nel gettare un ponte tra la traccia visibile e la cosa invisibile.
description: This essay investigates the psychological and perceptive view of reading as a visual fact and looks at its operations in different environments: from the traditional printed page to the more recent electronic page of the e-book, with particular attention reserved to the relationship between "word" (the linguistic aspects covered by the alphabetical vision) and "image" (image of the word and image with the word - visual hypertext integrated with verbal texts in e-book). In the light of the studies of the Psychology of perception, Neurophysiology and Phenomenology, the experience of reading is a function that transcends those value systems tending to oppose the categories of verbal and visual, intellect and intuition, logos and disorder. But literature shows even better the inviolability of belonging of word and image, and how the thinking in images consists in building a bridge between the visible trace and the invisible thing.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
Canadian perspective on managing multiple myeloma during the COVID-19 pandemic : lessons learned and future considerations
Creators: name: Foley, R.
name: Kaedbey, R.
name: Song, Kevin
name: Venner, C. P.
name: White, D.
name: Doucette, S.
name: Christofides, A
name: Reece, D. E
Publisher: name: MDPI
Year: 2021

description: The coronavirus disease 2019 (covid-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 has necessitated changes to the way patients with chronic diseases are managed. Given that patients with multiple myeloma are at increased risk of covid-19 infection and related complications, national bodies and experts around the globe have made recommendations for risk mitigation strategies for those vulnerable patients. Understandably, because of the novelty of the virus, many of the proposed risk mitigation strategies have thus far been reactionary and cannot be supported by strong evidence. In this editorial, we highlight some of the risk mitigation strategies implemented at our institutions across Canada during the first wave of covid-19, and we discuss the considerations that should be made when managing patients during the second wave and beyond.
Multi-objective Optimization of Butanol Production During ABE Fermentation
Creators: name: Sharif Rohani, Aida
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: ABE fermentation
Butanol
Multi-objective optimization
In-situ solvent recovery
Integrated fermentation
Net Flow Method

description: Liquid biofuels produced from biomass have the potential to partly replace gasoline. One of the most promising biofuels is butanol which is produced in acetone-butanol-ethanol (ABE) fermentation. The ABE fermentation is characterized by its low butanol concentration in the final fermentation broth. In this research, the simulation of three in situ recovery methods, namely, vacuum fermentation, gas stripping and pervaporation, were performed in order to increase the efficiency of the continuous ABE fermentation by decreasing the effect of butanol toxicity. The non-integrated and integrated butanol production systems were simulated and optimized based on a number of objectives such as maximizing the butanol productivity, butanol concentration, and butanol yield. In the optimization of complex industrial processes, where objectives are often conflicting, there exist numerous potentially-optimal solutions which are best obtained using multi-objective optimization (MOO). In this investigation, MOO was used to generate a set of alternative solutions, known as the Pareto domain. The Pareto domain allows to view very clearly the trade-offs existing between the various objective functions. In general, an increase in the butanol productivity resulted in a decrease of butanol yield and sugar conversion. To find the best solution within the Pareto domain, a ranking algorithm (Net Flow Method) was used to rank the solutions based on a set of relative weights and three preference thresholds. Comparing the best optimal solutions in each case study, it was clearly shown that integrating a recovery method with the ABE fermentation significantly increases the overall butanol concentration, butanol productivity, and sugar conversion, whereas butanol yield being microorganism-dependent, remains relatively constant.
Agalmatofilia. L'amore per le statue nel mondo antico: l'Afrodite di Cnido e il caso di Pigmalione
Agalmatophilia. The love for the statues in the Ancient World: the Cnidian Aphrodite and the case of Pygmalion
Creators: name: Ferrari, Giulia; Università Di Bologna
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Agalmatofilia; Sessualità; Afrodite; Pigmalione; Bambola.
Agalmatophilia; Sexuality; Cnidian Aphrodite, Pygmalion; Sex dolls

description: Si approfondisce il tema dell'attrazione sessuale per le statue, nota come  'agalmatofilia'. Essa risulta particolarmente diffusa nel mondo antico: rilevante il  caso dell'Afrodite Cnidia – opera prassitelica che secondo diverse fonti antiche  fu in grado di suscitare il desiderio erotico nell'osservatore. Il caso è  contestualizzato nell'ambito della Grecia antica, che attribuiva alle divinità  diverse capacità e che dava particolare importanza al valore della mimesis. Altro  caso di amore per le statue da cui non è possibile prescindere è quello di  Pigmalione narrato da Ovidio all'interno delle Metamorfosi. Qui, il potere  della poesia concede il raggiungimento del lieto fine, tramite la trasformazione  della statua in donna vera. Rispetto a questo secondo caso si approfondiranno le  analogie tra la statua plasmata da Pigmalione e l'oggetto bambola, le quali fanno  del mito una sorta di ponte concettuale verso una forma contemporanea di  agalmatofilia, che ha per oggetto le bambole gonfiabili.
description: The sexual attraction to statues, also known as 'agalmatophilia', seems to be prevalent in the Ancient World: the case of the Cnidian Aphrodite is of particular interest. According to multiples ancient sources, this statue, made by Praxiteles was able to arouse the erotic desire in the observer. However, this case must be contextualised in the ancient Greece, where different powers were ascribed to the divinities and great importance was given to Mimesis. The literary case of Pygmalion, recorded by Ovid in the Metamorphoses, plays a key role in this context as well. Here, the power of poetry allows the achievement of a happy end through the transformation of the statue into a real woman. Hereof we underline the analogies between the sculpture moulded by Pygmalion and the doll, which allow us to perceive in this myth a sort of conceptual bridge towards a contemporary form of agalmatophilia, the one that employs sex dolls.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
Regulation of Lipid Droplet Cholesterol Efflux from Macrophage Foam Cells: a Role for Oxysterols and Autophagy
Creators: name: Ouimet, Mireille
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: atherosclerosis
macrophage foam cell
lipolysis
cholesterol efflux
lipid droplet
autophagy

description: Macrophage foam cells are the major culprits in atherosclerotic lesions, having a prominent role in both lesion initiation and progression. With atherosclerosis being the main factor underlying cardiovascular complications, there is a long-standing interest on finding ways to reverse lipid buildup in plaques. Studies have shown that promoting reverse cholesterol transport (RCT) from macrophage foam cells is anti-atherogenic because it alleviates the cholesterol burden of the plaques. The goal of this thesis was to gain insight into the mechanisms that govern cholesterol efflux from macrophage foam cells. The first part of this study looked at the ability of different oxysterols to promote cholesterol efflux in unloaded as compared to lipid-loaded macrophages, and our major finding here is that epoxycholesterol decreases efflux in lipid-loaded macrophages. It appears that epoxycholesterol does so by impairing the release cholesterol from its cellular storage site, the lipid droplet (LD), where it accumulates in the form of cholesteryl esters (CE). These results highlighted the importance of cholesterol release from LDs for efflux; indeed, this process is increasingly being recognized as the rate-limiting step for RCT in vivo. Subsequent experiments aimed at elucidating the mechanisms that govern LD CE hydrolysis in macrophage foam cells lead to the discovery of a novel pathway involved in cholesterol efflux. Macrophage CE hydrolysis is classically defined as being entirely dependent on neutral CE hydrolases. In the second part of this study, we demonstrate that in addition to the canonical CE hydrolases, which mediate neutral lipid hydrolysis, lysosomal acid lipase (LAL) also participates in the hydrolysis of cytoplasmic CE. Autophagy is specifically triggered in macrophages by atherogenic lipoproteins and delivers LD CE to LAL in lysosomes, thus generating free cholesterol for efflux. This autophagy-mediated cholesterol efflux is a process that is primarily dependant on the ABCA1 transporter and, importantly, is important for whole-body RCT. Overall, the studies presented in this thesis support that macrophage LD CE hydrolysis is rate-limiting for cholesterol efflux and shed light on the mechanisms of cholesterol mobilization for efflux in macrophage foam cells.
Supplementary document for Heterodyne Brillouin microscopy for biomechanical imaging - 5420186.pdf
Creators: name: Taylor, Michael
name: Kijas, Amanda
name: Wang, Zhao
name: Lauko, Jan
name: Rowan, Alan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supporting Figures, calculations, and experimental details
TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
Creators: name: Wong, Derek
name: Sogerer, Lisa
name: Lee, Samantha S.
name: Wong, Victor
name: Lum, Amy
name: Levine, Adrian B.
name: Marra, Marco, 1966-
name: Yip, Stephen
Publisher: name: BioMed Central
Year: 2020

description: Background: Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through the derepression of targets downstream of the mitogen-activated protein kinase (MAPK) signaling cascade, such as oncogenic E26 transformation-specific (ETS) transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in both developmental and disease contexts to facilitate the repression of CIC target genes and promote the post-translational stability of CIC. However, little is known about the mechanisms at the base of ATXN1L-mediated CIC post-translational stability. Results: Functional in vitro studies utilizing ATXN1LKO human cell lines revealed that loss of ATXN1L leads to the accumulation of polyubiquitinated CIC protein, promoting its degradation through the proteasome. Although transcriptomic signatures of ATXN1LKO cell lines indicated upregulation of the mitogen-activated protein kinase pathway, ERK activity was found to contribute to CIC function but not stability. Degradation of CIC protein following loss of ATXN1L was instead observed to be mediated by the E3 ubiquitin ligase TRIM25 which was further validated using glioma-derived cell lines and the TCGA breast carcinoma and liver hepatocellular carcinoma cohorts. Conclusions: The post-translational regulation of CIC through ATXN1L and TRIM25 independent of ERK activity suggests that the regulation of CIC stability and function is more intricate than previously appreciated and involves several independent pathways. As CIC status has become a prognostic factor in several cancer types, further knowledge into the mechanisms which govern CIC stability and function may prove useful for future therapeutic approaches.
The Dynamics of Role Construction in Interprofessional Primary Health Care Teams
Creators: name: MacNaughton, Kate
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Role boundaries
Interprofessional collaboration
Influences on role construction
Comparative case study

description: This qualitative study explores how roles are constructed within interprofessional health care teams. It focuses on elucidating the different types of role boundaries, the influences on role construction and the implications for professionals and patients. A comparative case study was conducted with two interprofessional primary health care teams. The data collection included a total of 26 interviews (13 with each team) and non-participant observations of team meetings (2-3 meetings at each site). Thematic analysis was used to analyze the data and a model was developed to represent the emergent findings. The role boundaries are organized around interprofessional interactions (autonomous-collaborative boundaries) and the distribution of tasks (interchangeable-differentiated boundaries). Salient influences are categorized as structural, interpersonal and individual dynamics. The implications of role construction include professional satisfaction and more favourable wait times for patients. The elements in this conceptual model may be transferable to other interprofessional primary health care teams. It may benefit these teams by raising awareness of the potential impact of various within-team influences on role construction.
Richtig weit sind wir noch nicht gekommen
Creators: name: Münch, Rainer
Publisher: name: My University
Year: 2021

description: Der Präsident des Umweltbundesamts (UBA), Prof. Dr. Dirk Messner, über die notwendige Reduzierung des Flächenverbrauchs, umweltfreundliche Wohnformen in Stadt und Land sowie Anforderungen an eine bodenschonende Landwirtschaft. Quelle: Ländlicher Raum : Fachzeitschrift der ASG / Agrarsoziale Gesellschaft. - Göttingen. - (2021), Heft 01, Seite25