cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Insights in the structural understanding of amyloidogenicity and mutation-led conformational dynamics of amyloid beta (Aβ) through molecular dynamics simulations and principal component analysis
Creators: name: Raghavan, Sriram Srinivasa
name: Iqbal, Saleem
name: Ayyadurai, Niraikulam
name: Gunasekaran, Krishnasamy
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: Abnormal protein aggregation in the nervous tissue leads to several neurodegenerative disorders like Alzheimer’s disease (AD). In AD, accumulation of the amyloid beta (Aβ) peptide is proposed to be an early important event in pathogenesis. Significant research efforts are devoted so as to understand the Aβ misfolding and aggregation. Molecular dynamics (MD) simulations complement experiments and provide structural information at the atomic level with dynamics without facing the same experimental limitations. Artificial missense mutations are employed experimentally and computationally for providing insights into the structure–function relationships of amyloid-β in relation to the pathologies of AD. Present work describes the MD simulations for 100 ns so as to probe the structural and conformational dynamics of Aβ1-42 assemblies and its mutants. Essential dynamics analysis with respect to conformational deviation of Cα was evaluated to identify the largest residual fluctuation of Cα. Conformational stability of all Aβ mutants was analyzed by computing RMSD, deciphering the convergence is reached in the last 20 ns in all replicas. To highlight the low frequency mode of motion corresponding to the highest amplitude, atomic displacements seen in trajectory, distance pair principal component analysis (dpPCA) was performed, which adumbrated mutations strongly affect the conformational dynamics of investigated model when compared with wild type. Dynamic cross correlation matrix (DCCM) also suggests the conserved interactions of wild Aβ and imply mutations in β3–β4 loop region induce deformity and residual fluctuations as observed from simulation. Present study indicate the mutational energy landscape which induces deformation leading to fibrillation. Communicated by Ramaswamy H. Sarma
title: Degenerative Epidural Cysts of the Spine
Creators: name: Hui, Cathryn
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Neuroradiology spine
subject: CT
subject: MR
subject: Radiology

description: Learning Objectives Background Imaging Findings OR Procedure Details Conclusion Personal Information References
description: Learning Objectives: To describe the pathogenesis and MR imaging findings of epidural cysts within the spinal canal relatedto degenerative changes of the...
title: Are there Ways to Reduce Patients' Waiting Time for Computed Tomography Scan of the Head? A Study in a Tertiary University Hospital in SG
Creators: name: Makmur, Andrew
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Management
subject: Head and neck
subject: CT
subject: Radiology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: To identify factors that could reduce patients’ waiting time for CT scan of the...
title: Radiation Treatment Compliance in the Indigenous Population: Assessing the Northern Territory Model of Care
Creators: name: Le, Hien
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Education and training
subject: Radiation Oncology

description: Learning Objectives Background Imaging Findings OR Procedure Details Conclusion Personal Information References
description: Learning Objectives: 1. To determine if there is significant difference in compliance with radiotherapy between Indigenous and non-Indigenous patients in the Northern Territory 2. To ascertain which patient, disease and treatment factors, if any, may affect compliance...
title: Split course of high dose palliative pelvic radiation treatment in the management of patients with hormone refractory prostate cancer presenting with symptomatic locally progressive or recurrent disease
Creators: name: Gogna, Kumar
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Oncology
subject: Genital / Reproductive system male
subject: Urinary Tract / Bladder
subject: Radiation therapy / Oncology
subject: Radiation Oncology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: Local progression, in patients with hormone-refractory prostate cancer (HRPC) often causes significant morbidity. Pelvic radiation therapy can provide effective palliation in this setting, with most studies in the literature supporting the use of...
title: Hepatic hemangiomas, and other hemangiomatous tumors and tumor-like lesions: usual, unusual imaging manifestations, pitfalls and problem-solving MR techniques
Creators: name: Matsuzaki, Kenji
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: MR
subject: CT
subject: MR-Diffusion/Perfusion
subject: Haemangioma
subject: Liver

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: - To review the various imaging manifestations of hepatic hemangiomas, and other hemangiomatous tumors and tumor-like lesions. - To describe clinical and imaging features of hemangiomatous lesions for the differential diagnosis, pitfalls, and...
title: 3D PC Arterial Spin Labeling Outperforms Dynamic Susceptibility Contrast Techniques in the Surveillance of Primary Brain Neoplasms
Creators: name: Tanenbaum, Lawrence
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Neoplasia
subject: MR-Diffusion/Perfusion
subject: Neuroradiology brain

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Dynamic susceptibility contrast-enhanced (DSC) first pass gadolinium-based perfusion techniques are used routinely in the surveillance of primary brain neoplasms and are of value in differentiating residual or recurrent tumor from treatment-related...
Identification of 1,2,3-triazole-phthalimide derivatives as potential drugs against COVID-19: a virtual screening, docking and molecular dynamic study
Creators: name: Holanda, Vanderlan Nogueira
name: de Araújo Lima, Elton Marlon
name: da Silva, Welson Vicente
name: Maia, Rafael Trindade
name: de Lima Medeiros, Rafael
name: Ghosh, Arabinda
name: de Menezes Lima, Vera Lúcia
name: de Figueiredo, Regina Celia Bressan Queiroz
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this work we aimed to perform an in silico predictive screening, docking and molecular dynamic study to identify 1,2,3-triazole-phthalimide derivatives as drug candidates against SARS-CoV-2. The in silico prediction of pharmacokinetic and toxicological properties of hundred one 1,2,3-triazole-phtalimide derivatives, obtained from SciFinder® library, were investigated. Compounds that did not show good gastrointestinal absorption, violated the Lipinski's rules, proved to be positive for the AMES test, and showed to be hepatotoxic or immunotoxic in our ADMET analysis, were filtered out of our study. The hit compounds were further subjected to molecular docking on SARS-CoV-2 target proteins. The ADMET analysis revealed that 43 derivatives violated the Lipinski’s rules and 51 other compounds showed to be positive for the toxicity test. Seven 1,2,3-triazole-phthalimide derivatives (A7, A8, B05, E35, E38, E39, and E40) were selected for molecular docking and MFCC—ab initio analysis. The results of molecular docking pointed the derivative E40 as a promising compound interacting with multiple target proteins of SARS-CoV-2. The complex E40-Mpro was found to have minimum binding energy of −10.26 kcal/mol and a general energy balance, calculated by the quantum mechanical analysis, of −8.63 eV. MD simulation and MMGBSA calculations confirmed that the derivatives E38 and E40 have high binding energies of −63.47 ± 3 and −63.31 ± 7 kcal/mol against SARS-CoV-2 main protease. In addition, the derivative E40 exhibited excellent interaction values and inhibitory potential against SAR-Cov-2 main protease and viral nucleocapsid proteins, suggesting this derivative as a potent antiviral for the treatment and/or prophylaxis of COVID-19. Communicated by Ramaswamy H. Sarma
title: MRI of the normal and abnormal brainstem.
Creators: name: Serrano Velasco, Laura
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Neuroradiology brain
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Spectroscopy
subject: Diagnostic procedure
subject: Inflammation
subject: Ischaemia / Infarction
subject: Neoplasia

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: + Familiarity with normal brainstem anatomy as shwonon MR images is essential for proper interpretation of patology MR images of the brainstem. + Establish a differential diagnosis of the disorders most frequently on the brainstem depending on the...
title: Whole Breast Ultrasound with a Free Hand Ultrasound Automated Mapping and Annotating System, a Phantom Evaluation Study
Creators: name: Andrei, Silviu
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Breast
subject: Ultrasound
subject: Computer Applications-General
subject: Neoplasia

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The whole breast ultrasound (WBUS), in addition to mammograms, has demonstrated value for the breast cancer detection (1,2). However, WBUS, is a time consuming, operator dependent procedure, which limits its use. In the current study, we evaluate...
title: Characteristics of intramyocellular lipid content based on the difference in athletic sports by 3 T proton MR spectroscopy
Creators: name: Isobe, Tomonori
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Musculoskeletal soft tissue
subject: MR
subject: MR-Spectroscopy

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: To evaluate the difference in the intramyocellular lipid (IMCL) metabolism of a long-distance runner and a throw player by 3 T proton MR spectroscopy...
TRIPLE ThatCamp#2: Scientific Crowdfunding. Presentation and Results.
Creators: name: Arasteh-Roodsary, Sona Lisa
name: Lombardo, Tiziana
name: Disch, Leonie
name: Inkret, Ana
name: Cupar, Drahomira
name: Caliman, Lorena Maria
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
Crowdfunding
EOSC
SSH

description: In the 1-hour introduction workshop explaining the OPERAS crowdfunding channel featured on GoTriple, experts on scientific crowdfunding provide tips and tools to understand what crowdfunding is, how it can be applied to science, and how to launch a campaign to collect financial support from the crowd, but also communicate research in the most succesful way. The presentation features the introductionary slides as well as the results of the event as collected via the tool Miroboard.
ACE2-derived peptides interact with the RBD domain of SARS-CoV-2 spike glycoprotein, disrupting the interaction with the human ACE2 receptor
Creators: name: Souza, Pedro F. N.
name: Amaral, Jackson L.
name: Bezerra, Leandro P.
name: Lopes, Francisco E. S.
name: Freire, Valder N.
name: Oliveira, Jose T. A.
name: Freitas, Cleverson D. T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Vaccines could be the solution to the current SARS-CoV-2 outbreak. However, some studies have shown that the immunological memory only lasts three months. Thus, it is imperative to develop pharmacological treatments to cope with COVID-19. Here, the in silico approach by molecular docking, dynamic simulations and quantum biochemistry revealed that ACE2-derived peptides strongly interact with the SARS-CoV-2 RBD domain of spike glycoprotein (S-RBD). ACE2-Dev-PepI, ACE2-Dev-PepII, ACE2-Dev-PepIII and ACE2-Dev-PepIV complexed with S-RBD provoked alterations in the 3D structure of S-RBD, leading to disruption of the correct interaction with the ACE2 receptor, a pivotal step for SARS-CoV-2 infection. This wrong interaction between S-RBD and ACE2 could inhibit the entry of SARS-CoV-2 in cells, and thus virus replication and the establishment of COVID-19 disease. Therefore, we suggest that ACE2-derived peptides can interfere with recognition of ACE2 in human cells by SARS-CoV-2 in vivo. Bioinformatic prediction showed that these peptides have no toxicity or allergenic potential. By using ACE2-derived peptides against SARS-CoV-2, this study points to opportunities for further in vivo research on these peptides, seeking to discover new drugs and entirely new perspectives to treat COVID-19. Communicated by Ramaswamy H. Sarma
Structure analysis of the proteins associated with polyA repeat expansion disorders
Creators: name: Hernandez, Rolando
name: Facelli, Julio C.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: 60506 Virology

description: Repeat regions are low-complexity regions in the human genome that largely code for intrinsic disorder in proteins. Expansions outside the normal thresholds in repeat regions are likely to be pathogenic, leading to the so-called repeat expansion diseases. There have been numerous studies on the most common group of repeat expansion diseases, which are the polyglutamine (polyQ) repeat expansion diseases, but there has been much less work done on the second-largest group of expansion repeats disorders, which involves the expansion of polyalanine (polyA) repeat tracts. In this article, we present a comprehensive study of the structural changes predicted using I-TASSER when comparing the wild type and enlarged structures of all known polyA expansion disorders. The results show that there is a reduction in α helices, an increase in extended strands in parallel and/or anti-parallel β-sheet conformation, an increase in random coils/loops and irregular elements, and a large increase in solvent-accessible surface area. When compared to the findings in polyQ expansions disorders we see similar trends, suggesting that the polyQ and polyA repeat expansion causes similar effects on the respective proteins, which lead to higher misfolding and aggregation propensities. Communicated by Ramaswamy H. Sarma
Dimeric phosphorylation of glyoxalase I alters its symmetry and substrate binding mechanism: simulation studies
Creators: name: Barber, Lisa Michelle
name: Hussain, Zakir
name: Thomas, Merlin
name: Hung, Andrew
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Glyoxalase I (GLO1) is a dimeric esterase of the glyoxalase system. Phosphorylation of the residue T106 has been found to inhibit GLO1 activity, and contribute to the onset of oxidative stress and cellular damage. This research uses multiple molecular dynamics simulations and automated docking of both GLO1 and dimerically phosphorylated GLO1 (p2-GLO1) to predict the initial structural differences induced by phosphorylation, and their interaction with the intermediate substrate Hemimercaptal. This research indicates that immediately following phosphorylation, GLO1 exhibits reduced sphericity, partly caused by outward splaying of the loop region surrounding T106. Phosphorylation induces enhanced concerted motions in the loop composed of residues immediately surrounding T106, which are correlated with motions at the active site pocket at the distant, opposite end of the dimer. These T106 region loop motions result in the distortion of the shape of the active site, and potentially alter its accessibility. Phosphorylation alters the manner in which GLO1 interacts with Hemimercaptal. For GLO1, Hemimercaptal is predicted to bind to T106, which we propose constitutes a novel, highly accessible ‘capture site’ responsible for initial contact with the substrate. In contrast, for p2-GLO1, Hemimercaptal is unable to bind favourably to (phosphorylated) position T106, suggesting that this proposed transient ‘capture site’ is abolished upon phosphorylation of GLO1. Hence, a novel physiological role is here proposed for the known essential GLO1 residue T106. These results may further contribute to understanding the inhibition mechanism of GLO1 upon phosphorylation. Communicated by Ramaswamy H. Sarma
Identification of novel potential ricin inhibitors by virtual screening, molecular docking, molecular dynamics and MM-PBSA calculations: a drug repurposing approach
Creators: name: Botelho, Fernanda D.
name: Santos, Marcelo C.
name: Gonçalves, Arlan S.
name: França, Tanos C. C.
name: LaPlante, Steven R.
name: de Almeida, Joyce S. F. D.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: Ricin is a potent cytotoxin with no available antidote. Its catalytic subunit, RTA, damages the ribosomal RNA (rRNA) of eukaryotic cells, preventing protein synthesis and eventually leading to cell death. The combination between easiness of obtention and high toxicity turns ricin into a potential weapon for terrorist attacks, urging the need of discovering effective antidotes. On this context, we used computational techniques, in order to identify potential ricin inhibitors among approved drugs. Two libraries were screened by two different docking algorithms, followed by molecular dynamics simulations and MM-PBSA calculations in order to corroborate the docking results. Three drugs were identified as potential ricin inhibitors: deferoxamine, leucovorin and plazomicin. Our calculations showed that these compounds were able to, simultaneously, form hydrogen bonds with residues of the catalytic site and the secondary binding site of RTA, qualifying as potential antidotes against intoxication by ricin. Communicated by Ramaswamy H. Sarma
Insights in the structural understanding of amyloidogenicity and mutation-led conformational dynamics of amyloid beta (Aβ) through molecular dynamics simulations and principal component analysis
Creators: name: Raghavan, Sriram Srinivasa
name: Iqbal, Saleem
name: Niraikulam, Ayyadurai
name: Gunasekaran, Krishnasamy
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: Abnormal protein aggregation in the nervous tissue leads to several neurodegenerative disorders like Alzheimer’s disease (AD). In AD, accumulation of the amyloid beta (Aβ) peptide is proposed to be an early important event in pathogenesis. Significant research efforts are devoted so as to understand the Aβ misfolding and aggregation. Molecular dynamics (MD) simulations complement experiments and provide structural information at the atomic level with dynamics without facing the same experimental limitations. Artificial missense mutations are employed experimentally and computationally for providing insights into the structure–function relationships of amyloid-β in relation to the pathologies of AD. Present work describes the MD simulations for 100 ns so as to probe the structural and conformational dynamics of Aβ1-42 assemblies and its mutants. Essential dynamics analysis with respect to conformational deviation of C α was evaluated to identify the largest residual fluctuation of C α. Conformational stability of all Aβ mutants was analyzed by computing RMSD, deciphering the convergence is reached in the last 20 ns in all replicas. To highlight the low frequency mode of motion corresponding to the highest amplitude, atomic displacements seen in trajectory, distance pair principal component analysis (dpPCA) was performed, which adumbrated mutations strongly affect the conformational dynamics of investigated model when compared with wild type. Dynamic cross correlation matrix (DCCM) also suggests the conserved interactions of wild Aβ and imply mutations in β3–β4 loop region induce deformity and residual fluctuations as observed from simulation. Present study indicate the mutational energy landscape which induces deformation leading to fibrillation. Communicated by Ramaswamy H. Sarma
1 Brief an [Johann Caspar] Lavater
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1790

description: von Caroline Danby
description: Jahr ermittelt mit Bezug auf Besuch mit Ehemann in Zürich (9.1789)
description: Danby: 1755-1821, Ehefrau von William Danby (1752-1833), gem. Lavaters Fremdenbücher (9.1789): née Seymour
FOODRUS E-learning Content Co-Creation Workshop
Creators: name: Leitner, Dora
name: Rosell, María Beatriz
Publisher: name: Zenodo
Year: 2022
Subjects: e-learning
food waste
co-creation

description: Presentation of the FOODRUS internal co-creation workshop to discuss the scope and structure of the e-learning materials. During the workshop all innovative solutions were presented that will be part of the e-learning platform, using interactive tools such as a Miro Board to foster the discussions.
title: Radiation dose saving in CT – a briefing on current strategies
Creators: name: Gerstenmaier, Jan
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Radioprotection / Radiation dose
subject: CT
subject: Radiation safety

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To familiarise the radiologist with current radiation dose saving strategies in CT (computed tomography) and to help the radiologist identify potential dose savings in his/her own...
[Hans Jakob Aberli] : Ætatis. LV. Ao. 1684. objit Ao. 1689 9. januarii
Creators: name: Sulzer, Johann
Publisher: name: [s.n.]
Year: 1684
Subjects: Aberli, Hans Jakob1629-1689

description: Porträt von Hans Jakob Aberli (1629-1689), Pfarrer in Frauenfeld und Winterthur, mit Buch und roter Nelke. Oben rechts das Vollwappen der Familie Aberli von Winterthur
description: Datierung gemäss Jahreszahl auf dem Gemälde. Die Angabe zum Todesdatum des Dargestellten könnte später hinzugefügt worden sein
description: Das Gemälde wird Johann Sulzer (1665-1703) zugeschrieben
[Alfredo Cairati?]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1914

description: Wahrscheinlich handelt es sich beim Dargestellten um den Musiker und Komponisten Alfredo Cairati (1875-1960)
description: Anonyme/r Künstler/in. Künstlersignatur unten rechts: "G. Marcol[...?] / 914"
description: Aus dem Nachlass Cairati Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
title: Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus
Creators: name: Kan, Hirohito
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Tissue characterisation
subject: Dementia
subject: Physics
subject: MR-Diffusion/Perfusion
subject: Neuroradiology brain

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The apparent diffusion coefficient (ADC)of the white matter changed significantly during the cardiac cycle even if the effect of bulk motion was minimized. These changes synchronized the intracranial volume change ( Fig. 1 )[1]. The ADC changes...
Physical and Psychological Strain in Upper Austrian Elementary School Teachers – An observational study
Creators: name: Hoppe, Peter
name: Reibnegger, Harald
name: Boxhofer, Emmerich
name: Leeb, Astrid
name: Frenner, Iris
name: Schwartz, Bernhard
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Musculoskeletal disorders (MSDs) are a main cause of pain leading to high economic burden and psychosocial disadvantages. In addition, psychological stress impacts the overall health as well as the quality of life. Elementary school teachers clearly are a cohort with a high risk of MSDs and stress. The "BelaPrim" study was conducted to determine the physical and psychological conditions of elementary school teachers in Upper Austria and to investigate the influence of physical and psychological parameters on MSDs. Physical and mental strain was determined with the Nordic Musculoskeletal Questionnaire (NMQ) and the 11-item short version of a German work-related behaviour and experience assessment (AVEM), respectively. Despite a high prevalence of MSDs, high scores were found on personality dimensions. Furthermore, qualitative results indicated the need of administrative/pedagogical support. A linear regression model showed that body height (+), work engagement (+), and emotions (-) are predictors for the occurrence of back pain. Despite a high proportion of physical complaints, Upper Austrian elementary school teachers show good mental health. Body height, a high work engagement, and low level of emotions are predictors for the occurrence of back pain. Health initiatives for elementary schools should have a multifactorial view to improve teachers’ health.
Novel copper complexes of metronidazole and metronidazole benzoate: synthesis, characterization, biological and computational studies
Creators: name: Rafique, Bushra
name: Shafique, Kainat
name: Hamid, Sabahat
name: Kalsoom, Saima
name: Hashim, Muhammad
name: Mirza, Bushra
name: Jafri, Laila
name: Iqbal, Mudassir
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Synthesis and characterization of novel copper complexes of metronidazole benzoate (MTZ Benz), metronidazole (MTZ) in the presence of another ligand; dichloroacetic acid (DCA) were compared and reported in the present work. Different bacterial and fungus strains were ascertained to evaluate the biological potency of the synthesized complexes, that is, Escherichia coli, Bordetella bronceptica, Staphylococcus epidermidis, Baccilus pumilus, Staphylococcus aureus and yeast strain Saccharomyces cerevisiae. Agar diffusion method was employed to investigate in vitro antibacterial activities of the synthesized metal complexes and the tested parent ligands. α-Amylase and α-glucosidase inhibition studies of the synthesized complexes were also carried out. The antibacterial potential and α-amylase and α-glucosidase inhibition studies of complexes were further investigated by molecular docking studies, which supported the experimental results. Significant α-amylase and α-glucosidase inhibition activities were shown by the synthesized complexes. S-1 and S-5 were found to be most inhibitors of α-amylase and α-glucosidase having IC50 42.50, 44.80 and 4.52 µg/mL, 4.80 µg/mL, respectively. The newly synthesized copper complexes showed overall better biological activities compared to each parent ligands used. Communicated by Ramaswamy H. Sarma
title: High resolution endo-rectal coil imaging of local staging of prostate cancer: Comparison of spin-echo T2W imaging and 3D T2W imaging at 3.0T.
Creators: name: Dunne, Ruth
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Neoplasia
subject: Imaging sequences
subject: MR-Diffusion/Perfusion
subject: Abdomen

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To describe the technique of high resolution endorectal coil imaging at 3.0T for prostate cancer staging To compare the MRI staging of peripheral zone prostate cancer using 2D turbo spin-echo T2W and 3D volumetric turbo spin-echo T2W imaging...
[Gottfried Hermann Haefeli]
Creators: name: Freudweiler, Daniel Albert
name: Olbertz, R.
Publisher: name: [s.n.]
Year: 1810

description: Porträt des späteren Theologie-Studenten Gottfried Hermann Haefeli (1806-1827) als Knabe
description: Legat Frau Vogel-Hartmann Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
title: Differential diagnosis of uterine polyps: MR manifestations of various epithelial and mesenchymal tumors and tumor-like lesions, pitfalls and problem-solving MR techniques
Creators: name: Takeuchi, Mayumi
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Genital / Reproductive system female
subject: Pelvis
subject: MR

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To review the wide spectrum of uterine polyps including epithelial and mesenchymal tumors and tumor-like lesions. To describe clinical and MR features of uterine polyps for the differential diagnosis, pitfalls, and problem-solving MR...
title: Retrospective Audit of Referrals for Thyroid Ultrasound with FNA of a Thyroid Nodule
Creators: name: Lo, Glen
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Biopsy
subject: Ultrasound
subject: Ear / Nose / Throat
subject: Radiology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: Deciding whether a thyroid nodule requires fine needle aspiration (FNA) biopsy is not always straightforward; published guidelines vary, in particular the relevance of diagnostic ultrasound findings (i.e. radiologist’s interpretation of the...
Can molecular dynamics explain decreased pathogenicity in mutant camphecene-resistant influenza virus?
Creators: name: Borisevich, Sophia S.
name: Gureev, Maxim A.
name: Yarovaya, Оlga I.
name: Zarubaev, Vladimir V.
name: Kostin, Gennadiy A.
name: Porozov, Yuriy B.
name: Salakhutdinov, Nariman F.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The development of new anti-influenza drugs remains an active area, and efforts in this direction will likely continue far into the future. In this paper, we present the results of a theoretical study explaining the mechanisms behind the antiviral activity of camphor derivatives. These include camphecene and a number of its analogues. The compounds tested can inhibit hemagglutinin (HA) by binding to it at two possible sites. Moreover, the binding site located at the site of proteolysis is the most important. Serial passaging of influenza in the presence of camphecene leads to the formation of mutation-associated resistance. Specifically, camphecene causes a significant mutation in HA (V615L). This substitution likely reduces the affinity of the compound for the binding site due to steric restriction of the positioning of camphecene in the binding cavity. Molecular dynamics (MD) simulation results show that the mutant HA is a more stable structure in terms of thermodynamics. In other words, launching conformational rearrangements preceding the transition from pre- to post-fusion requires more energy than in wild type HA. This may well explain the lower virulence seen with the camphecene-resistant strain. Communicated by Ramaswamy H. Sarma
Delineation of an epitope recognized by a chikungunya virus anti-capsid monoclonal antibody on the protease domain using an immuno-informatics approach
Creators: name: Thite, Aabha
name: Agrawal, Megha
name: Pavitrakar, Daya
name: Cherian, Sarah
name: Damle, Rekha
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: The capsid-protein (CP) of chikungunya virus (CHIKV) is reported to generate a primary immune response in infected individuals during disease progression. CP-specific monoclonal antibodies (mAbs) developed in our laboratory, exhibited promising potential in diagnosing recent CHIKV infection in IgM capture ELISA. In this study we focused on the molecular and structural characterization of one such representative mAb ClVE4/D9 to delineate the epitope recognized by it using an immuno-informatics approach. The antigen-antibody interacting residues were found to lie within the dimer interface region of the CP, also predicted as a conformational epitope. This implies that the mAb could interfere during the process of nucleocapsid assembly, ultimately preventing budding and egress of the virus particle. The binding specificity of the mAb highlights the possibility of using this anti-CP antibody for therapeutic or prophylactic treatment against CHIKV. Communicated by Ramaswamy H. Sarma
title: Radiotherapy in the Management of High-Grade Gliomas diagnosed in Western AU: a Patterns of Care Study
Creators: name: Jackson, Melanie
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Oncology
subject: Radiation therapy / Oncology
subject: Radiation Oncology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: Radiotherapy (RT) plays an integral role in the management of high grade glioma (HGG). However, there is little information on the patterns of care in unselected Australian patients with HGG. The aim of this study was to examine the utilisation of...
Belebey vegrandis
Creators: name: Reisz, Robert R.
name: Müller, Johannes
name: Tsuji, Linda
name: Scott, Diane
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Bolosauria
Bolosauridae
Belebey
Belebey vegrandis

description: BELEBEY VEGRANDIS IVAKHNENKO, 1973
Holotype: PIN (Palaeontological Institute, Russian Academy of Science, Moscow, Russia) 104/50 maxillary bone with partly preserved palatine bone.
Referred specimens: SGU (Saratov Geological University, Saratov, Russia) 104/B-2020, a small complete skull that has been disarticulated (Figs 1–6); SGU 104/B-2021, a slightly larger, complete skull (Figs 7, 8); SGU 104/B-2022, a large, partial skull, preorbital region not preserved. This large individual was available for study but could not be illustrated.
Horizon and locality: Upper Kazanian, Middle Permian; Bashkortostan and Orenburg regions, Southern Russia.
Diagnosis: Bolosaurid parareptiles characterized by the presence of strongly procumbent incisiform dentition anteriorly, and linguo-labially elongated, bulbous, posterior cheek teeth with strongly developed longitudinal striations. Non-dental potential autapomorphies cannot be recognized because most of the other bolosaurid taxa are known from fragmentary cranial and mandibular elements.
description: Published as part of Reisz, Robert R., Müller, Johannes, Tsuji, Linda & Scott, Diane, 2007, The cranial osteology of Belebey vegrandis (Parareptilia: Bolosauridae), from the Middle Permian of Russia, and its bearing on reptilian evolution, pp. 191-214 in Zoological Journal of the Linnean Society 151 (1) on page 192, DOI: 10.1111/j.1096-3642.2007.00312.x, http://zenodo.org/record/5431970
title: Endovascular Embolization of the Spermatic Vein in the Treatment of Varicocele: A 6-year institutional review
Creators: name: Amir, Mazin
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Congenital
subject: Embolisation
subject: Fluoroscopy
subject: Catheter venography
subject: Veins / Vena cava
subject: Genital / Reproductive system male
subject: Interventional vascular
subject: Radiology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: Varicocoele treatment has traditionally been surgical, involving direct dilation of the gonadal vein. Endovascular embolization treatment performed within the Interventional Radiology Suite has more recently played an increasing role. The aim of...
In silico study indicates antimalarials as direct inhibitors of SARS-CoV-2-RNA dependent RNA polymerase
Creators: name: Doharey, Pawan Kumar
name: Singh, Vishal
name: Gedda, Mallikarjuna Rao
name: Sahoo, Amaresh Kumar
name: Varadwaj, Pritish Kumar
name: Sharma, Bechan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic. RNA-dependent RNA polymerase (RdRp) is the key component of the replication or transcription machinery of coronavirus. Therefore SARS-CoV-2-RdRp has been chosen as an important target for the development of antiviral drug(s). During the early pandemic of the COVID-19, chloroquine and hydroxychloroquine were suggested by the researchers for the prevention or treatment of SARS-CoV-2. In our study, the antimalarial compounds have been screened and docked against SARS-CoV-2-RdRp (PDB ID: 7BTF), and it was observed that the antimalarials chloroquine, hydroxychloroquine, and amodiaquine exhibit good affinity. Since the crystal structure of SARS-CoV-2-RdRp with its substrate is not available, poliovirus-RdRp crystal structure co-crystallized with its substrate ATP (PDB ID: 2ILY) was used as a reference structure. The superimposition of SARS-CoV-2-RdRp and poliovirus-RdRp structures showed that the active sites of both of the RdRps superimposed very well. The amino acid residues involved in the binding of ATP in the case of poliovirus-RdRp and residues involved in binding with the antimalarial compounds with SARS-CoV-2-RdRp were compared. In both cases, the conserved residues were found to be involved in establishing the interactions. The MMGBSA and molecular dynamic simulation studies were performed to strengthen our docking results. Further residues involved in binding of antimalarials with SARS-CoV-2-RdRp were compared with the residues involved in the SARS-CoV-2-RdRp complexed with remdesivir [PDB ID: 7BV2]. It was observed that co-crystallized remdesivir and docked antimalarials bind in the same pocket of SARS-CoV-2 -RdRp. Communicated by Ramaswamy H. Sarma
title: Abdominal X-Ray Interpretation - the Role of Computer-Assisted Instruction Tutorials for Medical Students
Creators: name: Zheng, Peter
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Education and training
subject: Computer applications
subject: Abdomen
subject: Conventional radiography
subject: Education
subject: Radiology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: Studies have shown that competency in x-ray image interpretation in medical students is inadequate for the level required in clinical practice, and that the current curriculum at medical schools do not emphasize the learning of this vital skill...
19 Briefe an [Johann Caspar] Lavater
Creators: name: Crugot, Martin
Publisher: name: [s.n.]
Year: 1761

description: von Martin Crugot
description: Crugot: fürstlich-carolathischer Hofprediger
description: Davon 1 Brief mit Beischrift an Felix Hess (Nr. 16)
description: Davon 1 Brief adressiert an Johann Georg Sulzer in Berlin zur Übergabe an Lavater (Nr. 15)
Exploring the binding interactions of janus green blue with serum albumins from spectroscopic and calorimetric studies aided by in silico calculations
Creators: name: Saha, Saumen
name: Bhattacharjee, Snehasish
name: Chowdhury, Joydeep
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Binding interactions of the phenazinium dye Janus green blue (JGB) with human and bovine serum albumins (BSA – and BSA) have been explored for the first time from multi-spectroscopic and calorimetric measurements aided by in silico calculations. The formation of ground state complexes between JGB and the respective serum albumins have been suggested from the UV–Vis and steady-state fluorescence spectroscopic studies. The nonlinear Stern Volmer (SV) plots at higher concentrations of JGB primarily indicate the formation of more than one ground state complexes in BSA –/BSA–JGB systems. Modified SV plots and isothermal titration calorimetry (ITC) studies however signify the possibilities of one type of binding complexes between HSA/BSA – JGB systems. Binding constants and the thermodynamic parameters associated with the HSA/BSA–JGB complexes have also been estimated from the ITC studies. Förster distances (R0) for HSA–JGB and BSA–JGB complexes are estimated from Förster resonance energy transfer (FRET) results. Variations in the micro-environment of the Tyr and Trp residues of the serum proteins in presence of JGB have been observed from the synchronous fluorescence measurements. The conformational changes in the protein structures induced by the dye JGB have been revealed from 3 D fluorescence and circular dichroism (CD) studies. The experimental observations are supported by in silico calculations. This in depth investigation on the interactions of serum albumins with JGB may provide the fundamental information toward exploring the therapeutic efficacy of JGB as a potent drug molecule. Communicated by Ramaswamy H. Sarma
3 Briefe an [Johann Caspar] Lavater
Creators: name: Custine, Delphine de Sabran
Publisher: name: [s.n.]
Year: 1795

description: von [Delphine de] Sabran V[euv]e Custine
description: Davon 1 Brief undatiert, nur Datum des Empfangs vorhanden (Nr. 191)
description: Davon 1 Brief mit 2 Beischriften (von Mutter u. Bruder Sabran?) (Nr. 193)
description: Custine: geb. de Sabran
title: A Cross-Sectional Study of Magnetic Resonance Angiography
Creators: name: Chowdhury, Md Sirajul
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Cardiovascular system
subject: MR-Angiography
subject: Diagnostic procedure
subject: Pathology
subject: Radiology

description: Purpose Methods and Materials Results Conclusion Personal Information References
description: Purpose: Purpose of this study is to analyse the radiological findings of a hundred cases of magnetic resonance angiography(MRA) done in our hospitals—Hospital Queen Elizabeth , Kotakinabalu , Sabah , Malaysia and BIRDEM Imaging centre , BSMMU imaging...
title: Infra-tentorial Extra-axial Lesions Revisited
Creators: name: Justaniah, Almamoon
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Neuroradiology brain
subject: MR
subject: CT
subject: Neoplasia
subject: Radiology

description: Learning Objectives Background Imaging Findings OR Procedure Details Conclusion Personal Information References
description: Learning Objectives: To delineate specific imaging features of certian infra-tentorial extra-axial lesions (EAL). To narrow the differential diagnosis of EAL based on specific locations. To incorporate additional helpful clues from other imaging studies. After this...
title: Why iterative reconstruction will have a positive impact on trauma patients
Creators: name: Read, Katrina
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2011
Subjects: subject: Emergency
subject: CT
subject: Radiation safety
subject: Trauma
subject: Radiology

description: Learning Objectives Background Imaging Findings OR Procedure Details Conclusion Personal Information References
description: Learning Objectives: •To illustrate through images how the iterative reconstruction method, iDose4 can maintain image quality with a lower radiation dose in trauma...