Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Creators: name: Völzke, Henry
name: Hocking, Lynne J.
name: Amin, Najaf
name: Bonnycastle, Lori L.
name: Liu, Yongmei
name: Barroso, Inês
name: Luan, Jian’an
name: Tanaka, Toshiko
name: Chasman, Daniel I.
name: Hadley, David
name: Rivera, Natalia V.
name: Aadahl, Mette
name: Vollenweider, Peter
name: Chu, Audrey Y.
name: Gläser, Sven
name: Kähönen, Mika
name: Hansen, Torben
name: Cadby, Gemma
name: Balkau, Beverley
name: Ahluwalia, Tarunveer S.
name: Zhao, Wei
name: Justesen, Johanne Marie
name: Rose, Lynda M.
name: Delgado, Graciela E.
name: Harald, Kennet
name: North, Kari E.
name: Xue, Luting
name: Völker, Uwe
name: Marten, Jonathan
name: Whitfield, John B.
name: Heid, Iris M.
name: Wilson, James F.
name: Pérusse, Louis
name: Zhao, Jing Hua
name: Hveem, Kristian
name: Feitosa, Mary F.
name: Hirschhorn, Joel N.
name: Franks, Paul W.
name: Prokopenko, Inga
name: Hernandez, Dena
name: Polasek, Ozren
name: Lorentzon, Mattias
name: Martin, Nicholas G.
name: Fox, Caroline S.
name: Hofman, Albert
name: Kutalik, Zoltan
name: Qi, Lu
name: Huang, Jie
name: den Hoed, Marcel
name: Langenberg, Claudia
name: Peters, Ulrike
name: Raitakari, Olli T.
name: Bielak, Lawrence F.
name: Boerwinkle, Eric
name: Sarzynski, Mark A.
name: Blangero, John
name: Yengo, Loic
name: Stančáková, Alena
name: Bellis, Claire
name: Renström, Frida
name: Narisu, Narisu
name: Auvinen, Juha
name: Chambers, John C.
name: Holzapfel, Christina
name: Lindgren, Cecilia M.
name: Ebeling, Tapani
name: Hollensted, Mette
name: van Duijn, Cornelia M.
name: Sternfeld, Barbara
name: Montgomery, Grant W.
name: Froguel, Philippe
name: Ong, Ken K.
name: Ahmad, Shafqat
name: Pasko, Dorota
name: Waeber, Gérard
name: Rawal, Rajesh
name: Koistinen, Heikki A.
name: Mangino, Massimo
name: Griffin, Paula J.
name: Sanna, Serena
name: Kleber, Marcus E.
name: Bergman, Richard N.
name: Johansson, Åsa
name: Campbell, Harry
name: Rasmussen-Torvik, Laura J.
name: Kilpeläinen, Tuomas O.
name: Hallmans, Göran
name: Young, Kristin L.
name: Marques-Vidal, Pedro M.
name: Huppertz, Charlotte
name: Porteous, David J.
name: Metspalu, Andres
name: Fornage, Myriam
name: Kvaløy, Kirsti
name: Laakso, Markku
name: Mahajan, Anubha
name: Adair, Linda S.
name: Fu, Mao
name: Brage, Søren
name: Perez, Jeremiah
name: James, Alan L.
name: Mohlke, Karen L.
name: Jansson, John-Olov
name: Müller-Nurasyid, Martina
name: Tan, Sian-Tsung
name: Vitart, Veronique
name: Scott, Robert A.
name: Heard-Costa, Nancy L.
name: Penninx, Brenda W. J. H.
name: Kinnunen, Leena
name: Scott, William R.
name: Gordon-Larsen, Penny
name: Lyytikäinen, Leo-Pekka
name: Padmanabhan, Sandosh
name: Launer, Lenore J.
name: Linneberg, Allan
name: Puolijoki, Hannu
name: van Vliet-Ostaptchouk, Jana V.
name: Harris, Tamara B.
name: Olden, Matthias
name: Wong, Andrew
name: de Geus, Eco J. C.
name: Rankinen, Tuomo
name: Corre, Tanguy
name: Tönjes, Anke
name: Haiman, Christopher A.
name: Grarup, Niels
name: Boehnke, Michael
name: Zillikens, M. Carola
name: Cucca, Francesco
name: Smith, Blair H.
name: Kristiansson, Kati
name: Zhang, Weihua
name: Lehne, Benjamin
name: Kuh, Diana
name: Cornelis, Marilyn
name: Kivimäki, Mika
name: Dueker, Nicole
name: Collins, Francis S.
name: Grammer, Tanja B.
name: Wild, Sarah
name: Lim, Elise
name: Paternoster, Lavinia
name: Nauck, Matthias
name: Kooner, Jaspal S.
name: Savonen, Kai
name: Sarti, Cinzia
name: Eriksson, Joel
name: Hastie, Nicholas D.
name: Bien, Stephanie
name: Sidney, Steve
name: Cupples, L. Adrienne
name: Mägi, Reedik
name: Klein, Robert J.
name: Beilby, John
name: Gong, Jian
name: Silbernagel, Günther
name: Gieger, Christian
name: Busonero, Fabio
name: Milaneschi, Yuri
name: Lohman, Kurt
name: Bonnefond, Amélie
name: Tammelin, Tuija
name: Järvelin, Marjo-Riitta
name: Cheng, Yu-Ching
name: Frayling, Timothy M.
name: Grallert, Harald
name: Smith, Jennifer A.
name: Jackson, Anne U.
name: Hassinen, Maija
name: Esko, Tõnu
name: Marre, Michel
name: Pedersen, Oluf
name: Strachan, David P.
name: Jhun, Min A.
name: Liu, Ching-Ti
name: Navarro, Pau
name: Bergmann, Sven
name: Barata, Llilda
name: Bertoni, Alain G.
name: Abecasis, Gonçalo R.
name: Willemsen, Gonneke
name: Peyser, Patricia A.
name: Luben, Robert
name: Kolcic, Ivana
name: Færch, Kristine
name: Tuomilehto, Jaakko
name: Juonala, Markus
name: Kooperberg, Charles
name: Swift, Amy J.
name: Havulinna, Aki S.
name: Borja, Judith B.
name: Demirkan, Ayse
name: Graff, Mariaelisa
name: Snieder, Harold
name: Mulas, Antonella
name: Qi, Qibin
name: Quaye, Lydia
name: van Grootheest, Gerard
name: Hartman, Catharina A.
name: Bandinelli, Stefania
name: Salomaa, Veikko
name: Snitker, Søren
name: Teumer, Alexander
name: Shuldiner, Alan R.
name: Thuillier, Dorothée
name: Hottenga, Jouke Jan
name: Holmens, Oddgeir L.
name: Komulainen, Pirjo
name: Gudnason, Vilmundur
name: Dörr, Marcus
name: Ngwa, Julius S.
name: Peters, Annette
name: Bragg-Gresham, Jennifer L.
name: Vohl, Marie-Claude
name: Männistö, Satu
name: Smith, Albert Vernon
name: Walker, Mark
name: Lakka, Timo A.
name: Chines, Peter S.
name: Wright, Alan F.
name: Vestergaard, Henrik
name: Eiriksdottir, Gudny
name: O’Connell, Jeffrey R.
name: Hayward, Caroline
name: Haller, Toomas
name: Workalemahu, Tsegaselassie
name: Huang, Tao
name: van der Most, Peter J.
name: Rivadeneira, Fernando
name: Uitterlinden, André G.
name: Justice, Anne E.
name: Kumari, Meena
name: Palmer, Lyle J.
name: Kuusisto, Johanna
name: Ridker, Paul M.
name: Weir, David R.
name: Monda, Keri L.
name: Männikkö, Reija
name: Gyllensten, Ulf
name: McCarthy, Mark I.
name: Huth, Cornelia
name: Oldehinkel, Albertine J.
name: Borecki, Ingrid B.
name: Faul, Jessica D.
name: Hutri-Kähönen, Nina
name: Zubair, Niha
name: Vandenput, Liesbeth
name: Wu, Ying
name: Johnson, Andrew D.
name: Lim, Unhee
name: Wareham, Nicholas J.
name: Sørensen, Thorkild I. A.
name: Nolte, Ilja M.
name: Ohlsson, Claes
name: Loos, Ruth J. F.
name: Buyske, Steve
name: März, Winfried
name: Bouchard, Claude
name: Boomsma, Dorret I.
name: Hayes, James E.
name: De Moor, Marleen H. M.
name: Harder, Marie Neergaard
name: Kardia, Sharon L. R.
name: Rauramaa, Rainer
name: Musk, 
name: Winkler, Thomas W.
name: Nettleton, Jennifer A.
name: Lehtimäki, Terho
name: Lemarchand, Loic
name: Hindorff, Lucia
name: Eicher, John D.
name: Rudan, Igor
name: Peyrot, Wouter J.
name: Thorand, Barbara
name: Strauch, Konstantin
name: Smith, George Davey
name: Stringham, Heather M.
name: Hui, Jennie
name: Huffman, Jennifer E.
name: Perola, Markus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.