cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adverse events associated with inclisiran: a real-world pharmacovigilance study of FDA adverse event reporting system (FAERS)
Creators: name: Li, Bing
name: Chen, Yan
name: Zhang, Yongyi
name: Qian, Mengying
name: Shan, Qing
name: Qian, Jiao
name: Guo, Jinmin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: To gain an improved comprehension of inclisiran safety in real-world settings by data mining from FAERS. Data were gathered between 1 December 2020 and 31 December 2023. The Medical Dictionary for Regulatory Activities (MedDRA) corresponding preferred term (PT) and system organ class (SOC) were used to categorize adverse medication reactions in AE reports (AERs). By using reported odds ratio (ROR) method, positive signals were identified. There were 2,652 reports of inclisiran, and 150 of those AEs had significant disproportionality. Among the 44 PTs with moderate clinical priority, 35 PTs were discovered on the medicine label, including 12 IMEs and 2 DMEs. Of note, 9 PTs were unanticipated AEs that were not discovered in the medication label or reported clinical studies, such as movement disorder (ROR: 3.05; 95%CI: 1.73,5.37), aphonia (ROR: 3.77; 95%CI: 1.79,7.91), and pulmonary congestion (ROR: 3.47; 95%CI: 1.44,8.34). Inclisiran was found to be related to 12 serious AEs. The median TTO of 1896 cases was 13.5 (IQR 0-100) days. We identified not only known AEs, but also new AE signals such as movement disorder. However, signals does not reveal actual risk, prospective clinical trials are still required to verify their causal connection.
Supplemental Material, sj-docx-1-spp-10.1177_19485506211023619 - The Chicken and Egg of Pride and Social Rank
Creators: name: Witkower, Zachary
name: Mercadante, Eric
name: Tracy, Jessica L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, sj-docx-1-spp-10.1177_19485506211023619 for The Chicken and Egg of Pride and Social Rank by Zachary Witkower, Eric Mercadante and Jessica L. Tracy in Social Psychological and Personality Science
Additional file 1 of Updated single cell reference atlas for the starlet anemone Nematostella vectensis
Creators: name: Cole, Alison G.
name: Steger, Julia
name: Hagauer, Julia
name: Denner, Andreas
name: Ferrer Murguia, Patricio
name: Knabl, Paul
name: Narayanaswamy, Sanjay
name: Wick, Brittney
name: Montenegro, Juan D.
name: Technau, Ulrich
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary Figures S1: S9 Complementary data figures for all partitions not further illustrated in the main manuscript. A) Partition identity highlighted on UMAP of the full dataset B) UMAP cell plot coloured by sample identity C) Barplot of absolute cell numbers in each sample, coloured by cell state identity. D) UMAP cell plot coloured by cell state identity. E, F) Dotplot expression of top five marker genes (E) and differentially expressed transcription factors (F) from each cluster. Expression separated between cells of the developmental series (Dark slate blue scale) and the adult tissue series (orange scale). Grey indicates average scaled expression of 0 or below. See Supplementary material for full gene lists. S9G Dotplot expression profile of specific immune related regulatory genes across the entire dataset. The signature is found within the immune partition (orange) but also in the immune-cells of the neuroglandular partition (box in green partition), but not shared with the putative immune signature of the inner cell layer (box in pink partition).
Aktuelle Daten und Trends zu Methicillin-resistenten Staphylococcus aureus (MRSA)
Creators: name: Layer, Franziska
name: Cuny, Christiane
name: Strommenger, Birgit
name: Werner, Guido
name: Witte, Wolfgang
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2012
Subjects: subject: Antibiotikaresistenz
subject: Hospital-assoziierte MRSA (HA-MRSA)
subject: Community-assoziierte MRSA (CA-MRSA)
subject: Livestock-assoziierte MRSA (LA-MRSA)
subject: Epidemiologie
subject: Antibiotic resistance
subject: Hospital-acquired MRSA (HA-MRSA)
subject: Community-acquired MRSA (CA-MRSA)
subject: Livestock-associated MRSA (LA-MRSA)
subject: Epidemiology
subject: 610 Medizin

description: Methicillin-resistente Staphylococcus aureus (MRSA) gehören weltweit zu den häufigsten Erregern nosokomialer Infektionen. Am Nationalen Referenzzentrum (NRZ) für Staphylokokken wird stetig eine repräsentative Anzahl an Isolaten aus deutschen Krankenhäusern und anderen medizinischen Einrichtungen analysiert, um die Dynamik des Auftretens und der Verbreitung von MRSA-Klonen zu verfolgen. Gemäß den vom NRZ vorgegebenen Kriterien für die Einsendung, werden vor allem Isolate aus einem gehäuften Auftreten von Infektionen sowie aus schweren Infektionsverläufen eingesandt. Der vorliegende Beitrag befasst sich mit aktuellen Daten aus dem NRZ für Staphylokokken zu Antibiotikaresistenzen und MRSA-Epidemiestämmen krankenhausassoziierter Infektionen. Weiterhin werden Ergebnisse zu Community-assoziierten MRSA, die außerhalb medizinischer Einrichtungen auftreten, und zu MRSA aus zoonotischen Reservoiren vorgestellt und diskutiert.
description: Nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a problem in hospital settings worldwide. The National Reference Centre for Staphylococci performs molecular typing on a representative sample set of MRSA isolates from German hospitals for assessing long-term trends thus following the dynamics of emergence and spread of MRSA clones. The article focuses on recent data concerning antibiotic resistance and epidemic MRSA in nosocomial settings and also reflects the impact of community-acquired MRSA and MRSA from zoonotic reservoirs. Identifying common and newly emerging clones is an on-going challenge in the changing epidemiology of MRSA and prevention of further spread needs molecular surveillance.
Reisebedingte Erkrankungen in Deutschland
Creators: name: Schöneberg, Irene
name: Rasch, Gernot
name: Apitzsch, Lothar
Publisher: name: Robert Koch-Institut
Year: 1999
Subjects: subject: Paratyphus
subject: Shigellose
subject: meldepflichtige Krankheiten
subject: Typhus
subject: Importierte Erkrankungen
subject: Imported diseases
subject: Notifiable diseases
subject: Typhoid fever
subject: Paratyphoid fever
subject: Shigellosis
subject: 610 Medizin

description: Personen, die internationale Grenzen überschreiten, sind in besonderem Maße gefährdet, Infektionskrankheiten zu erwerben. Eine Analyse des Auftretens gemeldeter übertragbarer Krankheiten in Deutschland zeigt: Eine große Zahl der Erkrankungen an Typhus, Paratyphus, Shigellose, Trichinose und Brucellose, die in den letzten Jahren in Deutschland zur Meldung kamen, wurde im Ausland erworben. Interventionsmaßnahmen sind vor allem bei den Infektionen des Magen-Darm-Traktes sowie bei den impfpräventablen Krankheiten notwendig.
description: Persons who cross international boundaries are at increased risk of contracting infectious diseases. An analysis of the reported communicable diseases in Germany shows: A large number of cases of typhoid fever, paratyphoid fever, shigella infections, trichinellosis and brucellosis notified during the last years in Germany originated from foreign countries. Intervention measures are necessary, above all, with regard to gastrointestinal infections and vaccine-preventable diseases.
Adverse Events Associated with Inclisiran: A Real-world pharmacovigilance study of FDA adverse event reporting system (FAERS)
Creators: name: Li, Bing
name: Chen, Yan
name: Zhang, Yongyi
name: Qian, Mengying
name: Shan, Qing
name: Qian, Jiao
name: Guo, Jinmin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: To gain an improved comprehension of inclisiran safety in real-world settings by data mining from the US Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS). In a retrospective pharmacovigilance study, disproportionality analysis was utilized to determine the AEs associated with inclisiran use as signals. Data were gathered between 1 December 2020 and 31 December 2023. The Medical Dictionary for Regulatory Activities (MedDRA) corresponding preferred term (PT) and system organ class (SOC) were used to categorize adverse medication reactions in AE reports (AERs). By using reported odds ratio (ROR) method, positive signals were identified. Clinical prioritization of signals was ranked by a semiquantitative score method based on three categories of clinical significance. This was performed by assessing five distinct features: AER number, ROR value, mortality percentage, designated (DME) or important medical event (IME), and biological plausibility. There were 2,652 reports of inclisiran, and 150 of those AEs had significant disproportionality signal. The clinical priority scores elucidated that 106 (70.67%), 44 (29.33%), and 0 PTs were classified as weak, moderate, and strong clinical priorities, respectively. Among the 44 PTs with moderate clinical priority, 35 PTs were discovered on the medicine label, including 12 IMEs and 2 DMEs, such as pancreatitis (DME, ROR 3.29), deafness (DME, ROR 2.10), myocardial Infarction (IME, ROR 3.50), angina unstable (IME, ROR 17.11), coronary artery occlusion (IME, ROR 5.65), arrhythmia (IME, ROR 2.15). Of note, 9 PTs had unanticipated AEs that were discovered in the medication label or reported clinical studies, such as movement disorder (ROR: 3.05; 95%CI: 1.73,5.37), aphonia (ROR: 3.77; 95%CI: 1.79,7.91), and pulmonary congestion (ROR: 3.47; 95%CI: 1.44,8.34). Inclisiran was found to be related to 12 serious AEs, including gait disturbance, hypertension, arthralgia, urinary tract infection, diabetes mellitus, dizziness, myocardial infarction, and chest pain. The median TTO of 1896 cases was 13.5 (IQR 0-100) days. Additionally, 39.72% (753/1896) of AEs occurred during the first day post-inclisiran commencement. We identified not only known AEs, but also new AE signals such as movement disorder.However, signals does not reveal actual risk, prospective clinical trials are still required to verify their causal connection.
Begleitforschung zu Freisetzungsexperimenten mit gentechnisch veränderten Pflanzen: «nice to know» oder «need to know»?
Creators: name: Brandt, Peter
Publisher: name: Robert Koch-Institut
Year: 1998
Subjects: subject: 610 Medizin

description: Derzeit gibt es 293 Standorte für Freisetzungsexperimente mit gentechnische veränderten Pflanzen in Deutschland. Mehr als die Hälfte dieser Freisetzungsstandorte liegt in den vier Bundesländern Niedersachsen (53), Mecklenburg-Vorpommern (43), Bayern (41) und Nordrhein-Westfalen (34). Wird die Laufzeit der genehmigten Freisetzungsvorhaben mit einbezogen, so ergeben sich bereits nach dem derzeitigen Stand nahezu 1000 Optionen auf Freisetzungsexperimente im Laufe der nächsten zehn Jahre. Begleitforschungsprojekte in Angliederung an die laufenden Freisetzungsexperimente mit gentechnische veränderten Pflanzen haben eine Vielzahl von diversen Einzelaspekten zum Untersuchungsgegenstand. Eine Koordination der Begleitforschungsprojekte ist derzeit nicht zu erkennen, da es mehrfachzu redundanten Untersuchungen kommt. Anhand der (Teil-) Ergebnisse aus den Begleitforschungsprojekten der Bundesländer Bayern, Niedersachsen, Rheinland-Pfalz, Sachsen und Sachsen-Anhalt zum a) «Horizontalen Gentransfer», b) zur Möglichkeit der erhöhten Fitness und c) zum Auskreuzen des Transgens wird exemplarisch aufgezeigt, daß diese Ergebnisse bislang nur bestätigenden und quantitativen Charakter hatten und daß sie nicht qualitativ eine Veränderung der Bewertungsgrundlage (Stand der Wissenschaft) herbeigeführt habven, aufgrund der die bisherigen Genehmingungen ausgesprochen worden sind.
description: Just now there are 293 sites for field trials with genetically modified plants in Germany. More than the half of the sites are within the four federal states ‘Niedersachsen’ (53), ‘Mecklenburg-Vorpommern’ (43), ‘Bayern’ (41) and ‘Nordrhein-Westfalen’ (34). Taking into account the duration of the field trials, which have been approved, already round about 1000 options for field trials can be calculated for the next ten years. Research projects in parallel to field trials with genetically modified plants focus on a lot of diverse aspects of these field trials. At that time there is no coordination of these research projects shown by many redundant investigations. Results of the research projects in parallel to field trials of the federal states ‘Bayern’, ‘Niedersachsen’, ‘Rheinland-Pfalz’, ‘Sachsen’ and ‘Sachsen-Anhalt’ with regard to a) the horizontal gene transfer, b) the possibility of higher fitness and c) the outcrossing of the transgene are shown. It will be illustrated by these examples that the results mentioned above only confirm and quantify the scientific data which were formerly the basis for decision and approval.
Assessment of adverse events of the novel antiepileptic drug lamotrigine: a real-world pharmacovigilance study based on FAERS
Creators: name: Tu, Lidan
name: Xiao, Jingyang
name: Hong, Qingxia
name: Ouyang, Aijun
name: Tu, Ying
name: Wang, Shuping
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Lamotrigine (LTG), a medication frequently prescribed for epilepsy. Despite its widespread use, there remains a lack of clarity regarding the drug’s safety profile when used over extended periods in large patient populations. This study evaluated the safety profile of LTG using the FDA Adverse Event Reporting System (FAERS), aiming to enhance clinical decision-making. We used disproportionate analyses, including the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayes geometric mean (EBGM), to identify signals of adverse reactions associated with LTG. A total of 187,024 records were reported, involving 905 adverse drug event (ADE) signals across 27 system organs classes (SOCs). We detected several known adverse event (AE) signals from the clinical trial phase, including seizures, rash, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Additionally, we uncovered several unforeseen and significant adverse effects that were not documented in the medication’s prescribing information, encompassing suicides, atrial septal defects, Brugada syndrome, and signals associated with aortic stenosis. Our analysis in the post-marketing setting reveals new AE signals associated with LTG, highlighting the need for ongoing risk surveillance.
Effective Confinement and Bond Strength of Grade 100 Reinforcement
Creators: name: Fleet, Eric
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Structural engineering
Civil engineering not elsewhere classified

description: The primary reinforcement used for construction of structural concrete members has a yield strength of 60 ksi. This reinforcement grade was incorporated into construction over 50 years ago and remains the standard. Recent advances in material technology have led to the development of commercially available reinforcing steel with yield strengths of 100 ksi. While greater yield strengths can be utilized in design, it is essential that the bars can be properly anchored and spliced to fully develop their strength. Although design expressions are available for this purpose, they were established considering 60 ksi reinforcement. Therefore, the objective of this research program is to evaluate the development of high-strength reinforcing steel and establish a design expression for the development and splicing of this steel. Two phases of experimental tests were conducted. Phase I was performed by Glucksman (2018) and investigated the influence of splice length and transverse reinforcement on bond strength over four series of beam tests. This study (Phase II) was conducted following Phase I and consisted of reinforced concrete slab and beam testing over three series. An investigation was conducted on reinforcement development with a focus on the effect of splice length, concrete compressive strength, stress-strain relationships of the steel (ASTM A615 vs. ASTM A1035), and transverse reinforcement. Based on the results, the influences of test variables were identified, and a new confinement model was developed that estimates the transverse reinforcement contribution to bond strength. Finally, a design expression is provided for calculating the development and splice lengths of high-strength reinforcement.
Area Level Deprivation Is an Independent Determinant of Prevalent Type 2 Diabetes and Obesity at the National Level in Germany. Results from the National Telephone Health Interview Surveys ‘German Health Update’ GEDA 2009 and 2010
Creators: name: Maier, Werner
name: Scheidt-Nave, Christa
name: Holle, Rolf
name: Kroll, Lars Eric
name: Lampert, Thomas
name: Du, Yong
name: Heidemann, Christin
name: Mielck, Andreas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2014
Subjects: subject: Humans
subject: Female
subject: Male
subject: Adult
subject: Aged
subject: Germany/epidemiology
subject: Middle Aged
subject: Obesity/epidemiology
subject: Risk Factors
subject: Prevalence
subject: Aged 80 and over
subject: Health Surveys
subject: Public Health Surveillance
subject: Odds Ratio
subject: Diabetes Mellitus
subject: Type 2/epidemiology
subject: 610 Medizin

description: Objective: There is increasing evidence that prevention programmes for type 2 diabetes mellitus (T2DM) and obesity need to consider individual and regional risk factors. Our objective is to assess the independent association of area level deprivation with T2DM and obesity controlling for individual risk factors in a large study covering the whole of Germany. Methods: We combined data from two consecutive waves of the national health interview survey ‘GEDA’ conducted by the Robert Koch Institute in 2009 and 2010. Data collection was based on computer-assisted telephone interviews. After exclusion of participants
This Side of the Long Tunnel: The Emergence of the Idea of Japan's 'Snow Country' in the Nineteenth Century
Creators: name: Sheikh, Tariq
Publisher: name: unknown
Year: 2020
Subjects: subject: Japanese literature
subject: Intellectual life
subject: Seventeenth century
subject: History
subject: Literature
subject: Sixteenth century

description: In Nobel laureate Kawabata Yasunari's novel Snow Country, the protagonist Shimamura refers to an "old book" which gave him in-depth knowledge about the region known in Japan as the "Snow Country". The name of the book is not disclosed by Kawabata, but it is now known that the "old book" is Hokuetsu Seppu (first published in 1837), written by Suzuki Bokushi (1770-1842). Suzuki Bokushi (1770-1842) was a peasant-entrepreneur, essayist and amateur haikai poet who lived in the Echigo province of Tokugawa period Japan, a region now designated as a "severe snowfall region". With increasing commercial activity in the late Tokugawa period, local products gained demand in markets throughout the country, which in turn made residents of the provinces aware of their regional identity. This resulted in a visible shift from "literary" representations of the periphery to more objective and information-based writings. This presentation will look at how Hokuetsu Seppu, for the first time, established the idea of the "snow country", not as a romanticized place beyond the tunnel which is visited occasionally, but as a region where people live their daily lives while coping with extreme weather.
Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE)
Creators: name: Mocroft, Amanda
name: Lundgren, Jens D.
name: Sabin, Miriam Lewis
name: Monforte, Antonella D'Arminio
name: Brockmeyer, Norbert
name: Casabona, Jordi
name: Castagna, Antonella
name: Costagliola, Dominique
name: Dabis, Francois
name: Wit, Stéphane De
name: Fätkenheuer, Gerd
name: Furrer, Hansjakob
name: Johnson, Anne M.
name: Lazanas, Marios K.
name: Leport, Catherine
name: Moreno, Santiago
name: Obel, Niels
name: Post, Frank A.
name: Reekie, Joanne
name: Reiss, Peter
name: Sabin, Caroline
name: Skaletz-Rorowski, Adriane
name: Suarez-Lozano, Ignacio
name: Torti, Carlo
name: Warszawski, Josiane
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2013
Subjects: subject: Humans
subject: Female
subject: Male
subject: Risk Factors
subject: Time Factors
subject: HIV Infections/epidemiology
subject: Europe/epidemiology
subject: Incidence
subject: Sensitivity and Specificity
subject: CD4 Lymphocyte Count
subject: HIV Infections/immunology
subject: Treatment Outcome
subject: Cooperative Behavior
subject: Disease Progression
subject: HIV Infections/diagnosis
subject: HIV Seropositivity/epidemiology
subject: Substance Abuse Intravenous/epidemiology
subject: 610 Medizin

description: Background: Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality. Methods and Findings: LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count
Additional file 1 of Dietary sodium acetate and sodium butyrate improve high-carbohydrate diet utilization by regulating gut microbiota, liver lipid metabolism, oxidative stress, and inflammation in largemouth bass (Micropterus salmoides)
Creators: name: Liu, Qiao
name: Cheng, Liangshun
name: Wang, Maozhu
name: Shen, Lianfeng
name: Zhang, Chengxian
name: Mu, Jin
name: Hu, Yifan
name: Yang, Yihui
name: He, Kuo
name: Yan, Haoxiao
name: Zhao, Liulan
name: Yang, Song
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. SA and SB requirements of different fish species. Table S2. Antibodies used for western blot analysis.
Evaluation of Virus Inactivation by Formaldehyde to Enhance Biosafety of Diagnostic Electron Microscopy
Creators: name: Möller, Lars
name: Schünadel, Livia
name: Nitsche, Andreas
name: Schwebke, Ingeborg
name: Hanisch, Manuela
name: Laue, Michael
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2015
Subjects: subject: negative staining
subject: virus
subject: formaldehyde
subject: inactivation
subject: plaque assay
subject: TCID50 assay
subject: diagnostic electron microscopy
subject: biosafety
subject: 610 Medizin

description: Formaldehyde (FA) fixation of infectious samples is a well-established protocol in diagnostic electron microscopy of viruses. However, published experimental data that demonstrate virus inactivation by these fixation procedures are lacking. Usually, fixation is performed immediately before the sample preparation for microscopy. The fixation procedure should transform viruses in a non–infectious but nonetheless structurally intact form in order to allow a proper diagnosis based on morphology. FA provides an essential advantage in comparison to other disinfectants, because it preserves the ultrastructure of biological material without interfering significantly with the preparation (i.e., the negative staining) and the detection of viruses. To examine the efficiency of FA inactivation, we used Vaccinia virus, Human adenovirus and Murine norovirus as models and treated them with FA under various conditions. Critical parameters for the inactivation efficiency were the temperature, the duration of the FA treatment, and the resistance of the virus in question. Our results show that FA inactivation at low temperature (4 °C) bears a high risk of incomplete inactivation. Higher temperatures (25 °C) are more efficient, although they still require rather long incubation times to fully inactivate a complex and highly robust virus like Vaccinia. A protocol, which applied 2% buffered FA for 60 min and a temperature–shift from 25 to 37 °C after 30 min was efficient for the complete inactivation of all test viruses, and therefore has the potential to improve both biosafety and speed of diagnostic electron microscopy.
Risk of thromboembolic events in patients co-treated with factor Xa-inhibiting direct oral anticoagulants and anti-seizure medications: insights from pharmacovigilance data
Creators: name: Ding, Lingqing
name: Chen, Congqin
name: Yang, Yongkuan
name: Xiao, Jie
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Limited data have raised concerns about an increased risk of thromboembolic adverse events in atrial fibrillation (AF) patients co-treated with factor Xa-inhibiting direct oral anticoagulants (FXa-DOACs) and anti-seizure medications (ASMs). However, evidence regarding this association remains controversial. This study aims to investigate the impact of ASMs on the reporting of thromboembolic events in FXa-DOAC-treated patients. This study analyzed data from the FDA Adverse Event Reporting System (FAERS) between 2011Q3 and 2024Q1 using the weighted composite score integrated by four pharmacovigilance signals [reporting odds ratio (ROR), Empirical Bayes Geometric Mean (EBGM), additive model and multiplicative model]. A total of 177 cases of thromboembolic events were identified in patients using combined FXa-DOACs and ASMs. Levetiracetam together with FXa-DOACs was associated with an increased risk of thromboembolic events, particularly apixaban (ROR: 2.29, 95%CI 1.56–3.38; EBGM05:1.32; additive model:0.14 > 0; multiplicative mode: 2.47 > 1;composite score:1) and rivaroxaban (ROR:3.81, 95% CI 2.77–5.26; EBGM05:1.99; additive model:0.13; multiplicative model:1.71; composite score:1). Valproic acid was associated with thromboembolic risk when with rivaroxaban (ROR:4.80, 95%CI 2.50–9.19; EBGM05:1.64; additive model:0.29; multiplicative model:8.48; composite score:1). This study suggests that the concomitant use of levetiracetam and valproic acid with FXa-DOACs is associated with an increased risk of thromboembolic events.
Public health management of invasive meningococcal disease in Baden-Wuerttemberg, Germany, 2012: adherence to guidance and estimation of resources required as determined in a survey of local health authorities
Creators: name: Murajda, Lukas
name: Aichinger, Elisabeth
name: Pfaff, Guenter
name: Hellenbrand, Wiebke
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Germany
subject: Sporadic invasive meningococcal disease
subject: Public health management
subject: 610 Medizin

description: Background: Invasive meningococcal disease (IMD) incidence in Germany is low, but management of contacts to prevent subsequent cases still requires resources. Local public health authorities (LHA) advise antibiotic post-exposure prophylaxis (PEP) and vaccination to close contacts as defined in national guidance. We aimed to audit implementation of recommendations for IMD public health management in the state of Baden-Wuerttemberg, Germany, and to estimate associated costs. Methods: We surveyed all 38 LHAs in Baden-Wuerttemberg to evaluate knowledge of national guidance and implementation of IMD contact management using standardized questionnaires. For IMD cases notified in 2012, we requested numbers of household and other contacts ascertained, including advice given regarding PEP and post-exposure vaccination, plus staff time required for their management. We estimated costs for advised antibiotics, LHA staff time and visits to emergency departments according to published sources. The cost of preventing a subsequent case was estimated based on the number of household contacts that received PEP per IMD case and on the previous finding that ~284 household contacts must receive PEP to prevent one subsequent IMD case. Results: Although LHAs were familiar with national recommendations, they did not advise PEP to 4% of household contacts, while 72% and 100% of school and health provider contacts, respectively, were advised PEP. Only 25% of household contacts of a case with a vaccine-preventable serogroup were advised post-exposure vaccination. A mean of 11.0 contacts/IMD case (range 0–51), of which 3.6 were household contacts, were recommended PEP. Per IMD case, mean costs for LHA staff were estimated at €440.86, for antibiotics at €219.14 and for emergency department visits to obtain PEP at €161.70 - a total of €821.17/IMD case. Preventing a subsequent IMD case would cost ~ €65,000. Conclusions: Our results provide insight into costs of IMD public health management in Germany. We identified marked underuse of post-exposure vaccination in household contacts and overuse of PEP in school and health care contacts. In view of an estimated 3–6 quality-adjusted life years lost per case of IMD, our estimated cost of €65,000 for preventing a subsequent case seems justifiable.
THE EFFECT OF WATER MOLECULES ON HEADGROUP ORIENTATION AND SELF-ASSEMBLY PROPERTIES OF NON-COVALENTLY TEMPLATED PHOSPHOLIPIDS.
Creators: name: Biechele-Speziale, John A
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Computational chemistry
Biologically active molecules
Theoretical and computational chemistry not elsewhere classified

description: Simulations of various hydration levels of lamellar phase 23:2 Diyne PC were performed, and subsequent, serial docking simulations of a tyrosine monomer were replicated for each system in both hydrated and dehydrated states.
The goal was to evaluate how hydration impacts self-assembly and crystallization on the surface, and
whether or not these simulations, when run sequentially, could determine the answer. It was discovered that hydrated and dehydrated surfaces behave differently, and that
headgroup orientation plays a role in the initial docking and self-assembly process of the tyrosine monomer. It was also determined that potential energy as a sole metric
for determining whether or not a specific conformation of intermolecular orientation is not entirely useful, and docking scores are likely useful metrics in discriminating between conformations with identical potential energy values.
sj-docx-1-sgo-10.1177_21582440211030276 – Supplemental material for Psychotic Experiences and Alternate Dimensions: A Thematic Analysis Exploring Frameworks of Psychotic Symptoms Among Saudis
Creators: name: Hyder, Sanaa
name: Almutlaq, Nouf
name: Naseem, Mohammad Talal
name: Bilal, Lisa
name: Al-Subaie, Abdullah
name: Al-Habeeb, AbdulHameed
name: Altwaijri, Yasmin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-sgo-10.1177_21582440211030276 for Psychotic Experiences and Alternate Dimensions: A Thematic Analysis Exploring Frameworks of Psychotic Symptoms Among Saudis by Sanaa Hyder, Nouf Almutlaq, Mohammad Talal Naseem, Lisa Bilal, Abdullah Al-Subaie, AbdulHameed Al-Habeeb and Yasmin Altwaijri in SAGE Open
Differences in safety profiles of anti-herpesvirus medications: a real-world pharmacovigilance study based on the FAERS database
Creators: name: He, Dan
name: Kong, Dexuan
name: Zeng, Yanbin
name: Han, Meifen
name: Zhang, Shunguo
name: Li, Zhiling
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Anti-herpesvirus drug safety profiles have not been systematically compared. Understanding variations in adverse events (AEs) could provide reference for rational clinical use. We collected data on acyclovir, ganciclovir, valaciclovir, and foscarnet from the FDA Adverse Event Reporting System (FAERS) database from Q1 2004 to Q3 2023. Disproportionality analyses were conducted to evaluate the risk of AEs. All drugs exhibited significant associations with hematotoxicity, with ganciclovir and foscarnet being more myelosuppressive. The correlation with renal impairment ranked as follows: foscarnet, ganciclovir, valaciclovir, and acyclovir (ROR = 16.72, 7.06, 3.51, and 2.02, respectively). Regarding hepatotoxicity, ganciclovir was associated with acute-on-chronic liver failure (ROR = 52.83), and foscarnet was associated with fulminant hepatitis (ROR = 49.91). In the nervous system, acyclovir showed the highest intensity of neurotoxicity (ROR = 14.95). Valaciclovir ranked first in toxic encephalopathy (ROR = 64.70). Foscarnet showed the highest intensity of status epilepticus (ROR = 6.45). Besides, acyclovir showed the strongest association with severe cutaneous adverse reactions (SCARs). Our study revealed differences in safety profiles of four anti-herpesvirus medications. Ganciclovir exhibited the highest risk of hematotoxicity but appeared relatively safe in seizures and SCARs. Foscarnet was more likely to induce nephrotoxicity, seizures, and electrolyte imbalances than others. Acyclovir and valaciclovir were strongly associated with plasmacytosis, neurotoxicity, and SCARs.
Evaluation of Endotracheal Tube Cuff Pressure and The Use of Three Cuff Inflation Syringe Devices in Dogs
Creators: name: Hung, Wan-Chu
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Veterinary medicine (excl. urology)

description: Over-inflation of an endotracheal tube (ETT) cuff may lead to tracheal necrosis, whereas under- inflation increases the risk of pulmonary aspiration. The objectives of this 2-phase study were to 1) identify the frequency of abnormal ETT cuff inflation in anesthetized dogs, 2) evaluate ETT cuff inflation with 3 devices (regular syringe, Tru-CuffTM syringe, AG Cuffill syringe) in achieving proper cuff pressure (20-30 cmH2O). Dogs undergoing general anesthesia at Purdue Veterinary Medicine Teaching Hospital (PVMTH) were included. The standard operating procedure (SOP) of PVMTH was used for ETT size selection and cuff inflation. The results of objective 1 showed that 50 of the 80 dogs required ETT cuff inflation. Among these 50 dogs, only 14% had proper cuff inflation; 76% of the cuffs were over-inflated and 10% were under-inflated. For objective 2, 90 dogs were equally assigned to the 3 devices for ETT cuff inflation and cuff pressure was assessed with an aneroid manometer. The results showed that 80% of the ETT cuffs were over-inflated with the regular syringe, whereas only 6.7% and 3.3% ETT cuffs were over-inflated with the Tru-CuffTM and AG Cuffill syringes, respectively. The AG Cuffill syringe treatment group had a significantly higher percentage of proper inflated ETT cuffs (86.7%; both p < 0.05) compared to the other two groups (regular [3.3%]; Tru-CuffTM [50%]). We concluded that there was a high frequency of improper ETT cuff inflation when using SOP coupled with a regular syringe. The use of an AG Cuffill syringe significantly reduced improper ETT cuff inflation.
Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis
Creators: name: Mikalsen, Theresa
name: Pedersen, Torunn
name: Willems, Rob
name: Coque, Teresa M.
name: Werner, Guido
name: Sadowy, Ewa
name: Schaik, Willem Van
name: Jensen, Lars Bogø
name: Sundsfjord, Arnfinn
name: Hegstad, Kristin
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2015
Subjects: subject: Hospital associated/clinical enterococcus
subject: Horizontal gene transfer
subject: Mobile genetic elements
subject: Antibiotic resistance
subject: 610 Medizin

description: Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGEs). Here, we investigate this mobilome in successful hospital associated genetic lineages, E. faecium sequence type (ST)17 (n=10) and ST78 (n=10), E. faecalis ST6 (n=10) and ST40 (n=10) by DNA microarray analyses. Results: The hybridization patterns of 272 representative targets including plasmid backbones (n=85), transposable elements (n=85), resistance determinants (n=67), prophages (n=29) and clustered regularly interspaced short palindromic repeats (CRISPR)-cas sequences (n=6) separated the strains according to species, and for E. faecalis also according to STs. RCR-, Rep_3-, RepA_N- and Inc18-family plasmids were highly prevalent and with the exception of Rep_3, evenly distributed between the species. There was a considerable difference in the replicon profile, with rep17/pRUM, rep2/pRE25, rep14/EFNP1 and rep20/pLG1 dominating in E. faecium and rep9/pCF10, rep2/pRE25 and rep7 in E. faecalis strains. We observed an overall high correlation between the presence and absence of genes coding for resistance towards antibiotics, metals, biocides and their corresponding MGEs as well as their phenotypic antimicrobial susceptibility pattern. Although most IS families were represented in both E. faecalis and E. faecium, specific IS elements within these families were distributed in only one species. The prevalence of IS256-, IS3-, ISL3-, IS200/IS605-, IS110-, IS982- and IS4-transposases was significantly higher in E. faecium than E. faecalis, and that of IS110-, IS982- and IS1182-transposases in E. faecalis ST6 compared to ST40. Notably, the transposases of IS981, ISEfm1 and IS1678 that have only been reported in few enterococcal isolates were well represented in the E. faecium strains. E. faecalis ST40 strains harboured possible functional CRISPR-Cas systems, and still resistance and prophage sequences were generally well represented. Conclusions: The targeted MGEs were highly prevalent among the selected STs, underlining their potential importance in the evolution of hospital-adapted lineages of enterococci. Although the propensity of inter-species horizontal gene transfer (HGT) must be emphasized, the considerable species-specificity of these MGEs indicates a separate vertical evolution of MGEs within each species, and for E. faecalis within each ST.
Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
Creators: name: Witkowski, Peter T.
name: Leendertz, Siv Aina J.
name: Auste, Brita
name: Akoua-Koffi, Chantal
name: Schubert, Grit
name: Klempa, Boris
name: Muyembe-Tamfum, Jean-Jacques
name: Karhemere, Stomy
name: Leendertz, Fabian
name: Krüger, Detlev H.
Publisher: name: Robert Koch-Institut
Year: 2015
Subjects: subject: hantavirus
subject: Africa
subject: seroprevalence
subject: Côte d’Ivoire
subject: Democratic Republic of Congo
subject: tropical rain forest
subject: 610 Medizin

description: Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and bats since 2006. To investigate the human contact to hantaviruses carried by these hosts and to assess the public health relevance of hantaviruses for humans living in the tropical rainforest regions of Western and Central Africa, we performed a cross-sectional seroprevalence study in the region of Taï National Park in Côte d’Ivoire and the Bandundu region near the Salonga National Park in the Democratic Republic (DR) of Congo. Serum samples were initially screened with enzyme-linked immunosorbent assays using nucleoproteins of several hantaviruses as diagnostic antigens. Positive results were confirmed by Western blotting and immunofluorescence testing. Seroprevalence rates of 3.9% (27/687) and 2.4% (7/295), respectively, were found in the investigated regions in Côte d’Ivoire and the DR Congo. In Côte d’Ivoire, this value was significantly higher than the seroprevalence rates previously reported from the neighboring country Guinea as well as from South Africa. Our study indicates an exposure of humans to hantaviruses in West and Central African tropical rainforest areas. In order to pinpoint the possible existence and frequency of clinical disease caused by hantaviruses in this region of the world, systematic investigations of patients with fever and renal or respiratory symptoms are required.
Developing an Institutional Compliance Program: A Case Study Assessing the Organizational Structure of Two Universities
Creators: name: Cooks, Kendra Alise
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Higher education

description: Compliance programs have grown since the early 1990s and evolved more formally into corporate institutional or enterprise-wide programs with the passage of the Sarbanes-Oxley Act of 2002. Formal institutional compliance programs are emerging in colleges and universities to assist in the management of the myriad of regulations and requirements placed on them by accrediting bodies, creditors, boards, donors, grantors, and federal and state regulators. An effective compliance program provides the structure for the institution and its employees to conduct operations ethically, with integrity, and in compliance with legal and regulatory requirements. The goals of this study were to identify organizational structures that assist large, public universities in effectively managing institutional compliance, the elements that shape these structures, and the benefits and limitations of those structures.
Additional file 1 of Understanding primary care transformation and implications for ageing populations and health inequalities: a systematic scoping review of new models of primary health care in OECD countries and China
Creators: name: Henderson, D. A. G
name: Donaghy, E
name: Dozier, M
name: Guthrie, B
name: Huang, H
name: Pickersgill, M
name: Stewart, E
name: Thompson, A
name: Wang, H. H. X
name: Mercer, S. W
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. PRISMA-ScR Checklist. Table S2. MEDLINE Search terms. Table S3. Characteristics of included studies. Fig. S1. Included studies by country and methodology. Fig. S2. Count of types of primary care transformation in included studies, by policy. Fig. S3: Count of types of primary care transformation in included studies, by policy (alt). Fig. S4. Count of outcome measures in included studies, by policy. Fig. S5. Outcome measures in included studies, by methodology. Fig. S6. Types of health inequalities measured (n=37). Fig. S7. Studies citing barriers and facilitators to PCT (n=41), by methodology and country. Fig. S8. Included studies by year
HIV Testing and Diagnosis Rates in Kiev, Ukraine: April 2013 - March 2014
Creators: name: Kücherer, Claudia
name: Simmons, Ruth
name: Bartmeyer, Barbara
name: Malyuta, Ruslan
name: Chentsova, Nelli
name: Medoeva, Antonia
name: Kruglov, Yuri
name: Yurchenko, Alexander
name: Copas, Andrew
name: Porter, Kholoud
name: Hamouda, Osamah
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Humans
subject: Female
subject: Male
subject: Adolescent
subject: Adult
subject: Risk Factors
subject: Young Adult
subject: HIV Infections/epidemiology
subject: Mass Screening/methods
subject: Incidence
subject: Risk-Taking
subject: HIV Infections/diagnosis
subject: Homosexuality Male/psychology
subject: Acquired Immunodeficiency Syndrome/diagnosis
subject: Acquired Immunodeficiency Syndrome/epidemiology
subject: Heterosexuality/psychology
subject: Sexual Partners/psychology
subject: Ukraine/epidemiology
subject: 610 Medizin

description: Objective: Data from Ukraine on risk factors for HIV acquisition are limited. We describe the characteristics of individuals testing for HIV in the main testing centres of the Ukrainian capital Kiev, including HIV risk factors, testing rates, and positivity rates. Methods: As part of a larger study to estimate HIV incidence within Kiev City, we included questions on possible risk factors for HIV acquisition and testing history to existing systems in 4 infectious disease clinics. Data were provided by the person requesting an HIV test using a handheld electronic tablet. All persons (≥16yrs) presenting for an HIV test April 2013–March 2014 were included. Rates per 100,000 were calculated using region-specific denominators for Kiev. Results: During the study period 6370 individuals tested for HIV, equivalent to a testing rate of 293.2 per 100,000. Of these, 467 (7.8%) were HIV-positive, with the highest proportion positive among 31–35 year olds (11.2%), males (9.4%), people who inject drugs (PWID) (17.9%) and men who have sex with men (MSM) (24.1%). Using published population size estimates of MSM, diagnosis rates for MSM ranged from 490.6to 1548.3/100,000. A higher proportion of heterosexual women compared to heterosexual men reported contact with PWID, (16% vs. 4.7%) suggesting a bridging in risk between PWID and their sexual partners. Conclusion: Collection of HIV risk factor information in Kiev, essential for the purposes of developing effective HIV prevention and response tools, is feasible. The high percentage of MSM among those testing positive for HIV, may indicate a significant level of undisclosed sex between men in national figures.
sj-pdf-1-asp-10.1177_00037028211028278 - Supplemental material for Quantification of Starch Order in Physically Modified Rice Flours Using Small-Angle X-ray Scattering (SAXS) and Fourier Transform Infrared (FT-IR) Spectroscopy
Creators: name: Ishikawa, Daitaro
name: Yang, Jiamin
name: Fujii, Tomoyuki
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-asp-10.1177_00037028211028278 for Quantification of Starch Order in Physically Modified Rice Flours Using Small-Angle X-ray Scattering (SAXS) and Fourier Transform Infrared (FT-IR) Spectroscopy by Daitaro Ishikawa, Jiamin Yang and Tomoyuki Fujii in Applied Spectroscopy
Additional file 1 of Comprehensive genomic analysis of Bacillus subtilis and Bacillus paralicheniformis associated with the pearl millet panicle reveals their antimicrobial potential against important plant pathogens
Creators: name: Ashajyothi, Mushineni
name: Mahadevakumar, Shivannegowda
name: Venkatesh, Y. N.
name: Sarma, Pullabhotla V. S. R. N.
name: Danteswari, Chalasani
name: Balamurugan, Alexander
name: Prakash, Ganesan
name: Khandelwal, Vikas
name: Tarasatyavathi, C.
name: Podile, Appa Rao
name: Mysore, Kirankumar S.
name: Chandranayaka, Siddaiah
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 1.