cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial
Creators: name: Wang, Xuan-Yi
name: Mahmood, Syed Faisal
name: Jin, Fang
name: Cheah, Wee Kooi
name: Ahmad, Muhammad
name: Sohail, Mian Amjad
name: Ahmad, Waheed
name: Suppan, Vijaya K.
name: Sayeed, Muneeba Ahsan
name: Luxmi, Shobha
name: Teo, Aik-Howe
name: Lee, Li Yuan
name: Qi, Yang-Yang
name: Pei, Rong-Juan
name: Deng, Wei
name: Xu, Zhong-Hui
name: Yang, Jia-Ming
name: Zhang, Yan
name: Guan, Wu-Xiang
name: Yu, Xiong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Waning of neutralizing titres along with decline of protection efficacy after the second dose of COVID-19 vaccines was observed, including China-made inactivated vaccines. Efficacy of a heterologous boosting using one dose of a recombinant SARS-CoV-2 fusion protein vaccine (V-01) in inactivated vaccine-primed population was studied, aimed to restore the immunity. A randomized, double-blind and placebo-controlled phase III trial was conducted in healthy people aged 18 years or older in Pakistan and Malaysia. Each eligible participant received one dose of the V-01 vaccine developed by Livzon Mabpharm Inc. or placebo within the 3-6 months after the two-dose primary regimen, and was monitored for safety and efficacy. The primary endpoint was protection against confirmed symptomatic SARS-CoV-2 infection. A total of 10,218 participants were randomly assigned to receive a vaccine or placebo. Virus-neutralizing antibodies were assessed in 419 participants. A dramatic increase (11.3-fold; 128.3–1452.8) of neutralizing titres was measured in the V-01 group at 14 days after the booster. Over two months of surveillance, vaccine efficacy was 47.8% (95%CI: 22.6–64.7) according to the intention-to-treat principle. The most common adverse events were transient, mild-to-moderate pain at the injection site, fever, headache, and fatigue. Serious adverse events occurred almost equally in V-01 (0.12%) and placebo (0.16%) groups. The heterologous boosting with the V-01 vaccine was safe and efficacious, which could elicit robust humoral immunity under the epidemic of the Omicron variant. Trial registration:ClinicalTrials.gov identifier: NCT05096832.
Investigation of Environmental Cadmium Sources in Eastern Kentucky
Creators: name: Maher, Elizabeth
Publisher: name: University of Kentucky Libraries
Year: 2018
Subjects: subject: Environmental Public Health
subject: Mining Engineering

description: Utilizing data collected by the University of Kentucky Lung Cancer Research Initiative (LCRI), this study investigated potential mining-related sources for the elevated levels of cadmium in Harlan and Letcher counties. Statistical analyses for this study were conducted utilizing SAS. A number of linear regression models and logarithmic models were used to evaluate the significance of the data. The linear regression models consisted of both simple and multivariate types, with the simple models seeking to establish significance between the potential sources and urine cadmium levels and the multivariate models seeking both to identify any statistically significant linear relationships between source types as well as establish a relationship between the potential source and the urine cadmium levels.

The analysis began by investigating which ingestion method caused the increased levels of cadmium exposure. The analysis included ingestion through water sources and inhalation of dust. Of these two, dust showed the higher level of correlation. The second step was to analyze a number of sources of dust, particularly those related to mining practices in the area. These included the proximity to the Extended Haul Road System, secondary haul roads, rail roads, and processing plants. Of the variables in the analysis, Extended Haul Roads, secondary haul roads, and rail roads showed no correlation, and only the proximity to processing plants showed statistical significance.
Additional file 3 of Terminology and methods used to differentiate injury intent of hospital burn patients in South Asia: a systematic scoping review protocol
Creators: name: Bebbington, Emily
name: Ramesh, Parvathy
name: Kakola, Mohan
name: McPhillips, Rebecca
name: Bibi, Fatima
name: Hanif, Atiya
name: Morris, Nia
name: Khan, Murad
name: Poole, Rob
name: Robinson, Catherine
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 3. Screening advice document.
Low-Toxin Clostridioides difficile RT027 Strains Exhibit Robust Virulence
Creators: name: Anwar, Farhan
name: Roxas, Bryan Angelo P.
name: Shehab, Kareem W.
name: Ampel, Neil
name: Viswanathan, V.K.
name: Vedantam, Gayatri
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Clostridioides difficile is a leading cause of healthcare-associated infections worldwide. Currently, there is a lack of consensus for an optimal diagnostic method for C. difficile infection (CDI). Multi-step diagnostic algorithms use enzyme immunosorbent analysis (EIA)-based detection of C. difficile toxins TcdA/TcdB in stool, premised on the rationale that EIA toxin-negative (Tox-) patients have less severe disease and shorter diarrhea duration. The aim of this study was to characterize toxigenic (i.e. tcdA/tcdB-positive) C. difficile strains isolated from diarrheic patient stool with an EIA Tox- (i.e. “discrepant”) CDI diagnostic test result. Recovered strains were DNA fingerprinted (ribotyped), subjected to multiple toxin, genome and proteome evaluations, and assessed for virulence. Overall, of 1243 C. difficile-positive patient stool specimens from Southern Arizona hospitals, 31% were discrepant. For RT027 (the most prevalent ribotype)-containing specimens, 34% were discrepant; the corresponding RT027 isolates were cytotoxic to cultured fibroblasts, but their total toxin levels were comparable to, or lower than, the historic low-toxin-producing C. difficile strain CD630. Nevertheless, these low-toxin RT027 strains (LT-027) exhibited similar lethality to a clade-matched high-toxin RT027 strain in Golden Syrian hamsters, and heightened colonization and persistence in mice. Genomics and proteomics analyses of LT-027 strains identified unique genes and altered protein abundances, respectively, relative to high-toxin RT027 strains. Collectively, our data highlight the robust virulence of LT-027 C. difficile, provide a strong argument for reconsidering the clinical significance of a Tox- EIA result, and underscore the potential limitations of current diagnostic protocols.
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial
Creators: name: Wang, Xuan-Yi
name: Mahmood, Syed Faisal
name: Jin, Fang
name: Cheah, Wee Kooi
name: Ahmad, Muhammad
name: Sohail, Mian Amjad
name: Ahmad, Waheed
name: Suppan, Vijaya K
name: Sayeed, Muneeba Ahsan
name: Luxmi, Shobha
name: Teo, Aik-Howe
name: Lee, Li Yuan
name: Qi, Yang-Yang
name: Pei, Rong-Juan
name: Deng, Wei
name: Xu, Zhong-Hui
name: Yang, Jia-Ming
name: Zhang, Yan
name: Guan, Wu-Xiang
name: Yu, Xiong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Waning of neutralizing titers along with decline of protection efficacy after the second dose of COVID-19 vaccines was observed, including China-made inactivated vaccines. Efficacy of a heterologous boosting using one dose of a recombinant SARS-CoV-2 fusion protein vaccine (V-01) in inactivated vaccine-primed population was studied, aimed to restore the immunity. A randomized, double-blind and placebo-controlled phase Ⅲ trial was conducted in healthy people aged 18 years or older in Pakistan and Malaysia. Each eligible participant received one dose of V-01 vaccine developed by Livzon Mabpharm Inc. or placebo within the3-6 months after the 2-dose primary regimen, and was monitored for safety and efficacy. The primary endpoint was protection against confirmed symptomatic SARS-CoV-2 infection. A total of 10,218 participants were randomly assigned to receive vaccine or placebo. Virus-neutralizing antibodies were assessed in 419 participants. A dramatic increase (11.3-fold; 128.3 to 1452.8) of neutralizing titers was measured in V-01 group at 14 days after the booster. Over two months of surveillance, vaccine efficacy was 47.8% (95%CI: 22.6 to 64.7) according to the intention-to-treat principle. The most common adverse events were transient, mild-to-moderate pain at the injection site, fever, headache, and fatigue. Serious adverse events occurred almost equally in V-01 (0.12%) and placebo (0.16%) groups. The heterologous boosting with V-01 vaccine was safe and efficacious, which could elicit robust humoral immunity under the epidemic of the Omicron variant.
MACHINE LEARNING MODEL FOR ESTIMATION OF SYSTEM PROPERTIES DURING CYCLING OF COAL-FIRED STEAM GENERATOR
Creators: name: Navarkar, Abhishek
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mechanical engineering not elsewhere classified
Knowledge representation and reasoning
Electrical engineering not elsewhere classified

description: The intermittent nature of renewable energy, variations in energy demand, and fluctuations in oil and gas prices have all contributed to variable demand for power generation from coal-burning power plants. The varying demand leads to load-follow and on/off operations referred to as cycling. Cycling causes transients of properties such as pressure and temperature within various components of the steam generation system. The transients can cause increased damage because of fatigue and creep-fatigue interactions shortening the life of components. The data-driven model based on artificial neural networks (ANN) is developed for the first time to estimate properties of the steam generator components during cycling operations of a power plant. This approach utilizes data from the Coal Creek Station power plant located in North Dakota, USA collected over 10 years with a 1-hour resolution. Cycling characteristics of the plant are identified using a time-series of gross power. The ANN model estimates the component properties, for a given gross power profile and initial conditions, as they vary during cycling operations. As a representative example, the ANN estimates are presented for the superheater outlet pressure, reheater inlet temperature, and flue gas temperature at the air heater inlet. The changes in these variables as a function of the gross power over the time duration are compared with measurements to assess the predictive capability of the model. Mean square errors of 4.49E-04 for superheater outlet pressure, 1.62E-03 for reheater inlet temperature, and 4.14E-04 for flue gas temperature at the air heater inlet were observed.
Investigation of X-ray emission from the unidentified TeV gamma-ray source HESS J1832-085 with Suzaku
Creators: name: Aktekin, Ebru
Publisher: name: arXiv
Year: 2025
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Observations conducted with H.E.S.S. at high energies have led to the discovery of numerous gamma-ray sources in the Galactic plane at TeV energies. One of these sources, HESS J1832-085, has been suggested to be a pulsar wind nebula (PWN); however, its nature is not yet fully understood. In this work, we analyze Suzaku data to investigate the X-ray spectral properties of HESS J1832-085. We found that the X-ray spectra are highly absorbed and well-represented by a power-law model with a photon index of $Γ\sim 1.5$, and an unabsorbed X-ray flux of $F_{\rm X} \sim 0.3 \times 10^{-11}$ erg cm$^{-2}$ s$^{-1}$ in the 2-10 keV energy band. The gamma-ray flux is approximately 66 times higher than the X-ray flux. Based on our X-ray analysis, we discuss the origin of the source HESS J1832-085. We propose that the PWN scenario is possible, although several issues still need to be resolved.
description: 7 pages, 4 Figures, 2 Tables; Accepted for publication in Advances in Space Research on February 28, 2025
RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant
Creators: name: Yang, Jianing
name: Hu, Xuejiao
name: Wang, Wenzhuo
name: Yang, Yujing
name: Zhang, Xinqiang
name: Fang, Wei
name: Zhang, Lei
name: Li, Shan
name: Gu, Bing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: The highly infectious Delta variant strain of SARS-CoV-2 remains globally dominant and undermines COVID-19 vaccines. Rapid detection of the Delta variant is crucial for the identification and quarantine of infected individuals. In this study, our aim was to design and validate a genotyping RT-LAMP method to detect Delta variants specifically. R203M in the N gene of SARS-CoV-2 was chosen as the Delta variant-specific mutation for genotyping. To target the R203M-harboring region and the conserved sequence of the N gene, two sets of primers were designed, and a Cq (quantification cycle) ratio-based RT-LAMP for SARS-CoV-2 and R203M detection was developed by analyzing the significant discrepancy in amplification efficiency of the two sets of primers. We validated the RT-LAMP method on 498 clinical specimens in parallel with RT-qPCR, and 84 Delta variants from 198 positive samples were determined by sequencing. Compared with traditional RT-qPCR analyses, RT-LAMP appears to be 100% accurate in detecting SARS-CoV-2 clinical samples. RT-LAMP has a good ability to distinguish between Delta and non-Delta variants under a Cq ratio threshold of 1.80. Furthermore, the AUC (area under the curve) of this method was 1.00; the sensitivity, specificity and accuracy were all 100%. In summary, we have proposed a rapid, accurate and cost-effective RT-LAMP method to detect SARS-CoV-2 and Delta variants, which may facilitate the surveillance of COVID-19.
Additional file 2 of Barriers and strategies for primary health care workforce development: synthesis of evidence
Creators: name: Endalamaw, Aklilu
name: Khatri, Resham B
name: Erku, Daniel
name: Zewdie, Anteneh
name: Wolka, Eskinder
name: Nigatu, Frehiwot
name: Assefa, Yibeltal
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2
Adjunctive Zoledronate + IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant tuberculosis1
Creators: name: Shen, Hongbo
name: Yang, Enzhuo
name: Guo, Ming
name: Yang, Rui
name: Huang, Guixian
name: Peng, Ying
name: Sha, Wei
name: Wang, Feifei
name: Shen, Ling
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Multidrug-resistant tuberculosis (MDR-TB) is a refractory disease with high mortality rate due to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment outcome of MDR-TB. Our decade-long studies demonstrated that phosphoantigen-specific Vγ2Vδ2 T cells play protective roles in immunity against TB. Here, we hypothesized that enhancing protective Vγ2Vδ2 T-effector cells could improve treatment outcome of MDR-TB. To address this, we employed clinically approved drugs Zoledronate (ZOL) and IL-2 to induce anti-TB Vγ2Vδ2 T-effector cells as adjunctive immunotherapy against MDR-TB infection of macaques. We found that adjunctive ZOL/IL-2 administrations during TB drugs treatment of MDR-TB-infected macaques significantly expanded Vγ2Vδ2 T cells and enhanced/sustained Vγ2Vδ2 T-effector subpopulation producing anti-TB cytokines until week 21. ZOL/IL-2 administrations, while expanding Vγ2Vδ2 T cells, significantly increased/sustained numbers of circulating CD4+ Th1 and CD8+ Th1-like effector populations, with some γδ T- or αβ T-effector populations trafficking to airway at week 3 until week 19 or 21 after MDR-TB infection. Adjunctive ZOL/IL-2 administrations after MDR-TB infection led to lower bacterial burdens in lungs than TB drugs alone, IL-2 alone or saline controls, and resulted in milder MDR-TB pathology/lesions. Thus, adjunctive Zoledronate + IL-2 administrations can enhance anti-TB Vγ2Vδ2 T- and αβ T-effector populations, and improve treatment outcome of MDR-TB.
allsheep.vcf
Creators: name: yang, ruizhi
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 300301
subject: Animal growth and development

description: 我们自己收集了吉尔吉斯羊（KIR）及其奇拉黑羊（QBS）的血液样本，从中提取DNA以生成Illumina Ovine SNP50 BeadChip数据。Illumina Ovine SNP50 BeadChip的Dorper绵羊（DOR）、萨福克绵羊（SUF）和胡绵羊（胡）数据来自其他地方。论文题目为Illumina Ovine SNP50 BeadChip的吉尔吉斯绵羊种群结构和选择性特征。
DATA MINING AND VISUALIZATION OF EARTH HISTORY DATASETS FROM GEOLOGICAL TIMESCALE CREATOR PROJECT
Creators: name: Zehady, Abdullah Khan
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Other earth sciences not elsewhere classified
Geology not elsewhere classified
Stratigraphy (incl. biostratigraphy, sequence stratigraphy and basin analysis)
Palaeontology (incl. palynology)
Palaeoclimatology

description: The Geologic TimeScale Creator (TSCreator) project has compiled a range of paleo-environmental and bio-diversity data which provides the opportunity to explore origination, speciation and extinction events. My PhD research has four major interconnected themes which include the visualization methods of evolutionary tree and the impacts of climate change on the evolution of life in longer and shorter timeframes: (1) Evolutionary range data of planktonic foraminifera and nannofossils over the Cenozoic era have been updated with our latest geological timescale. These evolutionary ranges can be visualized in the form of interactive, extensible evolutionary trees and can be compared with other geologic data columns. (2) A novel approach of integrating morphospecies and lineage trees is proposed to expand the scope of exploration of the evolutionary history of microfossils. It is now possible to visualize morphological changes and ancestor-descendant lineage relationships on TSCreator charts which helps mutual learning of these species based on genetic and bio-stratigraphic studies. (3) These evolutionary datasets have been used to analyze semi-periodic cycles in the past bio-diversity and characteristic rates of turnover. Well-known Milankovitch cycles have been found as the drivers of fluctuations in the speciation and extinction processes. (4) Within a shorter 2000-year time period, global cooling events might have been a factor of human civilization turnover. Using our regional and global cultural turnover time series data, the effect of climate change on human culture has been proposed. The enhancement of the evolutionary visualization system accomplished by this research will hopefully allow academic and non-academic users across the world to research and easily explore Earth history data through publicly available TSCreator program and websites.
Real-Time Precise Damage Characterization in Self-Sensing Materials via Neural Network-Aided Electrical Impedance Tomography: A Computational Study
Creators: name: Zhao, Lang
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mechanical engineering not elsewhere classified
Knowledge representation and reasoning
Artificial intelligence not elsewhere classified

description: Many cases have evinced the importance of having structural health monitoring (SHM) strategies that can allow the detection of the structural health of infrastructures or buildings, in order to prevent the potential economic or human losses. Nanocomposite material like the Carbon nanofiller-modified composites have great potential for SHM because these materials are piezoresistive. So, it is possible to determine the damage status of the material by studying the conductivity change distribution, and this is essential for detecting the damage on the position that can-not be observed by eye, for example, the inner layer in the aerofoil. By now, many researchers have studied how damage influences the conductivity of nanocomposite material and the electrical impedance tomography (EIT) method has been applied widely to detect the damage-induced conductivity changes. However, only knowing how to calculate the conductivity change from damage is not enough to SHM, it is more valuable to SHM to know how to determine the mechanical damage that results in the observed conductivity changes. In this article, we apply the machine learning methods to determine the damage status, more specifically, the number, radius and the center position of broken holes on the material specimens by studying the conductivity change data generated by the EIT method. Our results demonstrate that the machine learning methods can accurately and efficiently detect the damage on material specimens by analysing the conductivity change data, this conclusion is important to the field of the SHM and will speed up the damage detection process for industries like the aviation industry and mechanical engineering.
MPEC 2024-O23 : 2017 DM171
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2017 DM171

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Assessing potential pathogenicity of novel highly pathogenic avian influenza (H5N6) viruses isolated from Mongolian wild duck feces using a mouse model
Creators: name: Duong, Bao Tuan
name: Than, Duc Duong
name: Ankhanbaatar, Ulaankhuu
name: Gombo-Ochir, Delgerzul
name: Shura, Gansukh
name: Tsolmon, Amartuvshin
name: Mok, Chris Ka Pun
name: Basan, Ganzorig
name: Yeo, Seon Ju
name: Park, Hyun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Several novel highly pathogenic avian influenza (HPAIVs) A(H5N6) viruses were reported in Mongolia in 2020, some of which included host-specific markers associated with mammalian infection. However, their pathogenicity has not yet been investigated. Here, we isolated and evaluate two novel genotypes of A(H5N6) subtype in Mongolia during 2018–2019 (A/wildDuck/MN/H5N6/2018-19). Their evolution pattern and molecular characteristics were evaluated using gene sequencing and their pathogenicity was determined using a mouse model. We also compared their antigenicity with previous H5 Clade 2.3.4.4 human isolates by cross-hemagglutination inhibition (HI). Our data suggests that A/wildDuck/MN/H5N6/2018-19 belongs to clade 2.3.4.4h, and maintains several residues associated with mammal adaptation. In addition, our evaluations revealed that their isolates are less virulent in mice than the previously identified H5 human isolates. However, their antigenicity is distinct from other HPAIVs H5 clade 2.3.4.4, thus supporting their continued evaluation as potential infection risks and the preparation of novel candidate vaccines for their neutralization.
Additional file 1 of Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study
Creators: name: Xin, Qing
name: Li, Hao-Jia
name: Chen, Hao-Kai
name: Zhu, Xiao-Feng
name: Yu, Lin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Supplementary Material 1
sj-pdf-2-ppa-10.1177_09520767211034664 - Supplemental material for The evolution of collaborative networks: A social network analysis of Chinese environmental protection policy
Creators: name: Li, Yanwei
name: Huang, Jing
Publisher: name: SAGE Journals
Year: 2021
Subjects: International Relations
Public Administration
Social Policy

description: Supplemental material, sj-pdf-2-ppa-10.1177_09520767211034664 for The evolution of collaborative networks: A social network analysis of Chinese environmental protection policy by Yanwei Li and Jing Huang in Public Policy and Administration
Adjunctive Zoledronate+IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant tuberculosis.
Creators: name: Shen, Hongbo
name: Yang, Enzhuo
name: Guo, Ming
name: Yang, Rui
name: Huang, Guixian
name: Peng, Ying
name: Sha, Wei
name: Wang, Feifei
name: Shen, Ling
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Multidrug-resistant tuberculosis(MDR-TB) is a refractory disease with high mortality rate due to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment outcome of MDR-TB. Our decade-long studies demonstrated that phosphoantigen-specific Vγ2Vδ2 T cells play protective roles in immunity against TB. Here, we hypothesized that enhancing protective Vγ2Vδ2 T-effector cells could improve treatment outcome of MDR-TB. To address this, we employed clinically-approved drugs Zoledronate(ZOL) and IL-2 to induce anti-TB Vγ2Vδ2 T-effector cells as adjunctive immunotherapy against MDR-TB infection of macaques. We found that adjunctive ZOL/IL-2 administrations during TB drugs treatment of MDR-TB-infected macaques significantly expanded Vγ2Vδ2 T cells and enhanced/sustained Vγ2Vδ2 T-effector subpopulation producing anti-TB cytokines until week 21. ZOL/IL-2 administrations, while expanding Vγ2Vδ2 T cells, significantly increased/sustained numbers of circulating CD4+ Th1 and CD8+ Th1-like effector populations, with some γδ T- or αβ T-effector populations trafficking to airway at week 3 until week 19 or 21 after MDR-TB infection. Adjunctive ZOL/IL-2 administrations after MDR-TB infection led to lower bacterial burdens in lungs than TB drugs alone, IL-2 alone or saline controls, and resulted in milder MDR-TB pathology/lesions. Thus, adjunctive Zoledronate+IL-2 administrations can enhance anti-TB Vγ2Vδ2 T- and αβ T-effector populations, and improve treatment outcome of MDR-TB.
MPEC 2024-O24 : 2017 CE60
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2017 CE60

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Le marché en dérive selon Aristote: Cité saine, cité consumée. État, marché, société
Creators: name: Scandamis, Nikos
Publisher: name: RESuME
Year: 2018
Subjects: subject: Economic Integration
subject: Intégration économique
subject: Economic Liberalism
subject: Libéralisme économique
subject: Globalization
subject: Mondialisation
subject: Political Philosophy
subject: Philosophie politique
subject: Marketization
subject: Marchéisation
subject: Aristotle
subject: Aristote

description: La mondialisation de l’économie est une réalité qui s’installe progressivement, de manière complexe et inéluctable, à l’image d’un phénomène physique. Elle touche, par sa dimension planétaire, à toutes les structures sociales sans qu’aucune organisation internationale n’ait, jusqu’à nos jours, pu la contrôler. C’est, en fait, une réalité économique dont les racines et les effets devraient être recherchés bien au-delà de l’économie, à travers l’organisation sociale et politique, aussi bien dans un présent qui porte les signes de l’actuel que dans un passé qui, lui, en détermine les traits. Pourquoi se tourner donc vers Aristote pour gérer notre aporie face à un phénomène si moderne? Après tout, les conditions sociales sur lesquelles Aristote a pu méditer ont été très différentes des nôtres et, de l’aveu commun des économistes, sa pensée économique n’a pas marqué sa postérité.
Il n’en reste pas moins que le regard philosophique est actuellement plus que jamais nécessaire, sûrement face à l’ampleur du phénomène, mais aussi en raison de l’image parcellisée de l’homme dont font usage les sciences dites humaines. Une mise en relief de l’intuition d’Aristote sur la vraie nature du phénomène économique serait donc utile pour en éclairer les dérives passées et présentes. De toute façon, son intuition le réhabilite en tant que sociologue surtout pour avoir saisi l’essence de l’économie là où les économistes d’aujourd’hui restent prisonniers de la logique du marché comme point de départ. La recherche s’avère d’autant plus intéressante que Platon avait, dans la *République*, posé le problème en des termes qui n’ont jamais reçu de réponse satisfaisante jusqu’ici.
sj-pdf-1-mso-10.1177_20552173211037361 - Supplemental material for NMOSD-like and longitudinal extensive HTLV1-associated myelitis are extremes that flank an overlooked continuum
Creators: name: Bonnan, Mickael
name: Olindo, Stéphane
name: Signate, Aissatou
name: Lobjois, Quentin
name: Stephant, Maeva
name: Boulos, Dalia Dimitri
name: Cabre, Philippe
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-pdf-1-mso-10.1177_20552173211037361 for NMOSD-like and longitudinal extensive HTLV1-associated myelitis are extremes that flank an overlooked continuum by Mickael Bonnan Stéphane Olindo Quentin Lobjois Dalia Dimitri Boulos Philippe Cabre in Multiple Sclerosis Journal – Experimental, Translational and Clinical
Rankformer: A Graph Transformer for Recommendation based on Ranking Objective
Creators: name: Chen, Sirui
name: Han, Shen
name: Chen, Jiawei
name: Hu, Binbin
name: Zhou, Sheng
name: Wang, Gang
name: Feng, Yan
name: Chen, Chun
name: Wang, Can
Publisher: name: arXiv
Year: 2025
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Recommender Systems (RS) aim to generate personalized ranked lists for each user and are evaluated using ranking metrics. Although personalized ranking is a fundamental aspect of RS, this critical property is often overlooked in the design of model architectures. To address this issue, we propose Rankformer, a ranking-inspired recommendation model. The architecture of Rankformer is inspired by the gradient of the ranking objective, embodying a unique (graph) transformer architecture -- it leverages global information from all users and items to produce more informative representations and employs specific attention weights to guide the evolution of embeddings towards improved ranking performance. We further develop an acceleration algorithm for Rankformer, reducing its complexity to a linear level with respect to the number of positive instances. Extensive experimental results demonstrate that Rankformer outperforms state-of-the-art methods. The code is available at https://github.com/StupidThree/Rankformer.
description: Accepted by WWW2025
Autonomous Guidance for Multi-body Orbit Transfers using Reinforcement Learning
Creators: name: LaFarge, Nicholas Blaine
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Aerospace engineering not elsewhere classified

description: While human presence in cislunar space continues to expand, so too does the demand for `lightweight' automated on-board processes. In nonlinear dynamical environments, computationally efficient guidance strategies are challenging. Many traditional approaches rely on either simplifying assumptions in the dynamical model or on abundant computational resources. This research employs reinforcement learning, a subset of machine learning, to produce a controller that is suitable for on-board low-thrust guidance in challenging dynamical regions of space. The proposed controller functions without knowledge of the simplifications and assumptions of the dynamical model, and direct interaction with the nonlinear equations of motion creates a flexible learning scheme that is not limited to a single force model. The learning process leverages high-performance computing to train a closed-loop neural network controller. This controller may be employed on-board, and autonomously generates low-thrust control profiles in real-time without imposing a heavy workload on a flight computer. Control feasibility is demonstrated through sample transfers between Lyapunov orbits in the Earth-Moon system. The sample low-thrust controller exhibits remarkable robustness to perturbations and generalizes effectively to nearby motion. Effective guidance in sample scenarios suggests extendibility of the learning framework to higher-fidelity domains.
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection
Creators: name: Kurhade, Chaitanya
name: Zou, Jing
name: Xia, Hongjie
name: Liu, Mingru
name: Yang, Qi
name: Cutler, Mark
name: Cooper, David
name: Muik, Alexander
name: Sahin, Ugur
name: Jansen, Kathrin U.
name: Ren, Ping
name: Xie, Xuping
name: Swanson, Kena A.
name: Shi, Pei-Yong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here, we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titres (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5 SARS-CoV-2 spike variant showed the highest propensity to evade vaccine neutralization compared to the original Omicron variants BA.1. BA.1-convalescent sera neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and Deltacron-spike SARS-CoV-2s with GMTs of 15, 430, 110, 109, 102, 25, and 284, respectively. The unique mutation F486V in the BA.4/5 spike contributes to the increased evasion of antibody neutralization by sublineage BA.4/5. The low neutralization titres of vaccinated sera or convalescent sera from BA.1 infected individuals against the emerging and rapidly spreading Omicron BA.4/5 variants provide important results for consideration in the selection of an updated vaccine in the current Omicron wave. Trial registration: ClinicalTrials.gov; identifier: NCT04368728.
Engineering and Financial Analysis of a Wastewater Pant Upgrade
Creators: name: Taleyarkhan, Meher Rusi
Publisher: name: Purdue University Graduate School
Year: 2020

description: Municipal wastewater treatment plants treat wastewater such as domestic and industrial sewage and recirculates the clean water back into nature’s waterways. However, the wastewater treatment process is costly and complex. The cost of running a municipal wastewater treatment plant is funded via ratepayer fee dollars from customers and therefore receives a fixed budget for which to run the plant according to environmental standards. A local initiative was established to upgrade a Midwestern municipal wastewater facility to utilize biomass renewable energy to a greater extent than what is used by the wastewater facility. The first phase of the initiative tested the suitability of utilizing organic substrates from local industrial plants with the potential to produce larger amounts of biogas via anaerobic digestion. The analysis evaluated the technical and financial viability of utilizing biomass technologies to help power the facility efficiently and economically. The financial and technical analysis will include a cost-benefit analysis by comparing current and forecasted natural gas demand and costs for running heating the WWTP to biogas produced by the anerobic digesters. The results of the research study found that the industrial waste substrates are suitable for anaerobic digestion and yield a higher biogas potential than what is currently used for anaerobic digestion by the WWTP. The initial financial analysis found it is feasible and economical, for at least certain months of the year, for the WWTP to refrain from purchasing natural gas and instead utilize the produced biogas.
A Stock Market Trading System Using Deep Neural Network
Creators: name: Yong, Bang Xiang
name: ABDULLAH, AHMAD SHAHIDAN
name: ABDUL RAHIM, MOHD ROZAINI
Publisher: name: Springer Singapore
Year: 2017
Subjects: 38 Economics
3502 Banking, Finance and Investment
3801 Applied Economics
35 Commerce, Management, Tourism and Services

description: The stock market prediction is a lucrativefield of interest withpromising profit and covered with landmines for the unprecedented. The mar-kets are complex, non-linear and chaotic in nature which poses huge difficultiesto predict the prices accurately. In this paper, a stock trading system utilizingfeed-forward deep neural network (DNN) to forecast index price of Singaporestock market using the FTSE Straits Time Index (STI) in t days ahead is pro-posed and tested through market simulations on historical daily prices. There are40 input nodes of DNN which are the past 10 days’opening, closing, minimumand maximum prices and consist of 3 hidden layers with 10 neurons per layer.The training algorithm used is stochastic gradient descent with back-propagationand is accelerated with multi-core processing. A trading system is proposedwhich utilizes the DNN forecasting results with defined entry and exit rules toenter a trade. DNN performance is evaluated using RMSE and MAPE. Theoverall trading system shows promising results with a profit factor of 18.67,70.83% profitable trades and Sharpe ratio of 5.34 based on market simulation ontest data.
MULTIMODAL VIRTUAL LEARNING ENVIRONMENTS: THE EFFECTS OF VISUO-HAPTIC SIMULATIONS ON CONCEPTUAL LEARNING
Creators: name: Anazco, Mayari Serrano
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Educational technology and computing

description: Presently, it is possible to use virtual learning environments for simulating abstract and/or complex scientific concepts. Multimodal Virtual Learning Environments use multiple sensory stimuli, including haptic feedback, in the representation of concepts. Past research on the utilization of haptics for learning has shown inconsistent results when gains in conceptual knowledge had been assessed. This research focused on two abstract phenomena Electricity and Magnetism and Buoyancy. These abstract concepts were experienced by students using either visual, visuo-haptic, or hands-on learning activities. Embodied Cognition Theory was used as a for the implementation of the learning environments. Both phenomena were assessed using qualitative and quantitative data analysis techniques. Results suggested that haptic, visual, and physical modalities affected positively the acquisition of conceptual knowledge of both concepts.
Abcès pariétal abdominal secondaire à l’absorption d’un couteau par un malade mental, CHU de Treichville, Côte d’Ivoire
Creators: name: AHUE, Kouassi Henry Noël
name: GOHO, Kouide Marius
name: COULIBALY, N’golo Adama
name: KPAN, Kunka Jocelyne
Publisher: name: MTSI
Year: 2024

description: Abdominal parietal abscess secondary to the absorption of a knife by a mental patient, Treichville University Hospital, Côte d’Ivoire

Case Report. We present the successful management of the consequences of voluntary knife ingestion in a 24-year-old male with undocumented psychiatric disorders. The patient was admitted to the emergency department with a fistulized epigastric skin abscess, with the tip of a knife protruding from it. This extraordinary case involved the migration of an ingested knife, which perforated the stomach and externalized through an epigastric abscess. Surgical removal of the foreign body was performed.

Discussion. Several hypotheses explain the ingestion of the knife in a person with psychiatric disorders, including self-mutilation, the pernicious mystical influence of malevolent third parties, or self-administration of a neomystical ritual.

Conclusion. The development of a skin abscess secondary to foreign body ingestion is rare but should be considered in the absence of other causes.

Abcès pariétal abdominal secondaire à l’absorption d’un couteau par un malade mental, CHU de Treichville, Côte d’Ivoire

Observation. Nous présentons la prise en charge réussie des conséquences de l’ingestion volontaire d’un couteau chez un homme de 24 ans souffrant de troubles psychiatriques non documentés. Le patient a été reçu aux urgences pour un abcès cutané épigastrique fistulisé avec en son sein la pointe d’un couteau émergent. Il s’agissait de la migration extraordinaire d’un poignard ingéré qui a perforé l’estomac et s’est extériorisé par un abcès épigastrique. L’extraction chirurgicale du corps étranger a été réalisée.

Discussion. Les hypothèses des causes de l’ingestion de ce couteau chez une personne souffrant de troubles psychiatriques sont diverses?: automutilation, influence pernicieuse mystique de tiers malfaisants, autoadministration d’un néorituel mystique…

Conclusion. Le développement d'un abcès cutané secondaire à une pénétration d'un corps étranger au niveau du tube digestif est rare. Mais la présence d’un corps étranger doit être évoquée après l’élimination des autres causes.
description: MTSI, Vol. 4 No 4 (2024): MTSI-Revue
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection
Creators: name: Kurhade, Chaitanya
name: Zou, Jing
name: Xia, Hongjie
name: Liu, Mingru
name: Yang, Qi
name: Cutler, Mark
name: Cooper, David
name: Muik, Alexander
name: Sahin, Ugur
name: Jansen, Kathrin U.
name: Ren, Ping
name: Xie, Xuping
name: Swanson, Kena A.
name: Shi, Pei–Yong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titers (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5 SARS-CoV-2 spike variant showed the highest propensity to evade vaccine neutralization compared to the original Omicron variants BA.1. BA.1-convalescent sera neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and Deltacron-spike SARS-CoV-2s with GMTs of 15, 430, 110, 109, 102, 25, and 284, respectively. The unique mutation F486V in the BA.4/5 spike contributes to the increased evasion of antibody neutralization by sublineage BA.4/5. The low neutralization titers of vaccinated sera or convalescent sera from BA.1 infected individuals against the emerging and rapidly spreading Omicron BA.4/5 variants provide important results for consideration in the selection of an updated vaccine in the current Omicron wave. Trial registration:ClinicalTrials.gov identifier: NCT04368728..