cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sensitivity of flow harmonics to sub-nucleon scale fluctuations in heavy ion collisions
Creators: name: Noronha-Hostler, Jacquelyn
name: Noronha, Jorge
name: Gyulassy, Miklos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: In this paper a new procedure to smooth out the initial energy densities of hydrodynamics is employed to show that the initial spatial eccentricities $\varepsilon_{m,n}$, which drive the final state flow harmonics $v_n$, are remarkably robust with respect to variations of the underlying scale of initial energy density spatial gradients, $λ$, in nucleus-nucleus collisions. For $\sqrt{s}=2.76$ TeV Pb+Pb collisions, the $\varepsilon_{m,n}$'s (across centrality classes) change by less than $10\%$ if the scale of fluctuations is varied from $0.1$ to $1$ fm. We show, using the 2+1 Lagrangian hydrodynamic code, v-USPhydro, that this robustness is transferred to the final $v_n$'s computed within event by event viscous hydrodynamics. This indicates that the flow harmonics in nucleus-nucleus collisions are not yet particularly sensitive to the underlying microscopic sub-nucleon physics below the confinement scale. On the other hand, the eccentricities of top $1\%$ high multiplicity $\sqrt{s}=5.02$ TeV p+Pb collisions are found to be very sensitive to sub-nucleonic scale fluctuations, which should be contrasted with the robustness found in peripheral Pb+Pb collisions with the same multiplicity.
description: 22 pages, 17 figures; references added
School zone : a new model for suburban development in Montana
Creators: name: Halverson, John A.
name: 0000-0003-1322-8963
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Suburb growth management
School planning
Suburban development
School districts
School siting
Suburban sprawl
Small schools

description: “The last, best place,” Montana, has experienced sustained, rapid population growth in recent years. Millennials and Baby Boomers alike flock to the state to stake their claim on some of the last remaining housing markets that offer what many perceive as the “American Dream” of an affordable, suburban home in a small town. This population growth has sparked extensive suburban development throughout the state, prompting many public-school districts to build new facilities to accommodate this growth. Contemporary school siting practices favor large sites, which are usually found only at the edges of existing development. Once built, these new facilities attract home builders and families, further catalyzing suburban sprawl development (Beaumont and Pianca, 2002). This dynamic represents a classic “tragedy of the commons” case for government intervention at several levels. Continued, uncoordinated growth threatens the character of Montana cities. Contemporary suburban development patterns contribute to traffic safety hazards and congestion. The desirability of small, county schools drives population growth, pushing cash-strapped school districts to their limits. This report explores, through case studies, the ways in which status quo school siting (site acquisition) practices, local regulations, and legislation all contribute to fiscally unsustainable and dangerous suburban development patterns. The final chapter proposes a “School Zone” tool that coordinates local jurisdictions (city, county, school district) to leverage public investment in new school facilities as a means of creating more fiscally sustainable, compact, adaptable suburban development that provides a steadier student population, and safer cities in which those children might live
title: Revisiting the general linear model for radiology research
Creators: name: Castro Pereira, José
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Computer applications
subject: Experimental
subject: Computer Applications-General
subject: Statistics
subject: FOS: Mathematics
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To elucidate radiologists doing research on the strengths and weaknesses of linear models, their assumptions, and how to interpret their results using a dataset and R...
Further concepts and approaches for enhancing food system resilience
Creators: name: Ingram, John
name: Bellotti, William
name: Brklacich, Mike
name: Achterbosch, Thom
name: Balázs, Bálint
name: Banse, Martin
name: Fielke, Simon
name: Gordon, Line
name: Hasnain, Saher
name: Herman, Lieve
name: Kanter, Rebecca
name: Kaye-Blake, Bill
name: Mounsey, Jerome
name: Pihlanto, Anne
name: Quinlan, Allyson
name: Six, Johan
name: Stotten, Rike
name: Tomich, Thomas
name: Tóth, Attila
name: Yacamán, Carolina
name: Zurek, Monika
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management

description: The cornerstones to enhance food system resilience can be considered as three fundamental concepts, the '3Rs': robustness, based on the capacity of the food system actors to adapt their activities to resist disruptions to desired food system outcomes; recovery, based on the ability of food system actors to adapt their activities so as to be able to return to pre-existing food system outcomes following disruption; and reorientation, based on the ability of food system actors to adapt their activities based on accepting alternative food system outcomes as a strategy before or after disruption. The 3Rs are not mutually exclusive or hierarchical. Each is dynamic, complex and subject to unpredictable uncertainties, requiring innovations in institutions, governance mechanisms and other systems of accountability, as well as changes in culture, individual behaviour and technology. An appropriate balance is needed across the 3Rs, rather than advocating for singular solutions. While resilience strategies based on robustness and recovery may be more appropriate in the short term but not sustainable, reorientation is arguably a longer-term approach, suggesting practitioners need to situate shorter-term 'status quo' efforts within a longer-term, reorientated vision.
(401682) George Stratton Watson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Bright End of the z~9 and z~10 UV Luminosity Functions using all five CANDELS Fields
Creators: name: Bouwens, R. J.
name: Oesch, P. A.
name: Labbe, I.
name: Illingworth, G. D.
name: Fazio, G. G.
name: Coe, D.
name: Holwerda, B.
name: Smit, R.
name: Stefanon, M.
name: van Dokkum, P. G.
name: Trenti, M.
name: Ashby, M. L. N.
name: Huang, J. -S.
name: Spitler, L.
name: Straatman, C.
name: Bradley, L.
name: Magee, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The deep, wide-area (~800-900 arcmin**2) near-infrared/WFC3/IR + Spitzer/IRAC observations over the CANDELS fields have been a remarkable resource for constraining the bright end of high redshift UV luminosity functions (LFs). However, the lack of HST 1.05-micron observations over the CANDELS fields has made it difficult to identify z~9-10 sources robustly, since such data are needed to confirm the presence of an abrupt Lyman break at 1.2 microns. We report here on the successful identification of many such z~9-10 sources from a new HST program (z9-CANDELS) that targets the highest-probability z~9-10 galaxy candidates with observations at 1.05 microns, to search for a robust Lyman-break at 1.2 microns. The potential z~9-10 candidates are preselected from the full HST, Spitzer/IRAC S-CANDELS observations, and the deepest-available ground-based optical+near-infrared observations. We identified 15 credible z~9-10 galaxies over the CANDELS fields. Nine of these galaxies lie at z~9 and 5 are new identifications. Our targeted follow-up strategy has proven to be very efficient in making use of scarce HST time to secure a reliable sample of z~9-10 galaxies. Through extensive simulations, we replicate the selection process for our sample (both the preselection and follow-up) and use it to improve current estimates for the volume density of bright z~9 and z~10 galaxies. The volume densities we find are 5(-2)(+3)x and 8(-3)(+9)x lower, respectively, than found at z~8. When compared with the best-fit evolution (i.e., dlog_{10} rho(UV)/dz=-0.29+/-0.02) in the UV luminosities densities from z~8 to z~4 integrated to 0.3L*(z=3) (-20 mag), these luminosity densities are 2.6(-0.9)(+1.5)x and 2.2(-1.1)(+2.0)x lower, respectively, than the extrapolated trends. Our new results are broadly consistent with the "accelerated evolution" scenario at z>8, as seen in many theoretical models.
description: 23 pages, 15 figures, 7 tables, updated to match the version in press, including some minor textual corrections identified at the proof stage
title: Evaluation of medical devices on critically ill patients using portable chest radiography.
Creators: name: Cobo Ruiz, Teresa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: Mediastinum
subject: Thorax
subject: Plain radiographic studies
subject: Arterial access
subject: Catheters
subject: Complications
subject: Cardiac Assist Devices
subject: Haemodynamics / Flow dynamics

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review and illustrate the most common medical devices seen in critically ill patients using portable chest radiography in the ICU. To recognize and evaluate the correct position and common complications associated with these medical...
de Sitter gravity/Euclidean conformal gravity correspondence
Creators: name: Chatterjee, Atreya
name: Lowe, David A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The holographic dual of a gravitational theory around the de Sitter background is argued to be a Euclidean conformal gravity theory in one fewer dimensions. The measure for the holographic theory naturally includes a sum over topologies as well as conformal structures.
description: 19 pages, 2 figures
Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates
Creators: name: Gautel, Mathias
name: Alzate, Oscar
name: Hamlett, Eric D.
name: Rubel, Carrie E.
name: Patterson, Cam
name: DeKroon, Robert M.
name: Schisler, Jonathan C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ubiquitin-proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, and neurodegeneration. Protein ubiquitination plays a central role in both the promotion of proteasomal degradation as well as cellular signaling through regulation of the stability of transcription factors and other signaling molecules. Substrate specificity is a critical regulatory step of ubiquitination and is mediated by ubiquitin ligases. Recent studies implicate ubiquitin ligases in multiple models of cardiac diseases such as cardiac hypertrophy, atrophy, and ischemia/reperfusion injury, both in a cardioprotective and maladaptive role. Therefore, identifying physiological substrates of cardiac ubiquitin ligases provides both mechanistic insights into heart disease as well as possible therapeutic targets. Current methods identifying substrates for ubiquitin ligases rely heavily upon non-physiologic in vitro methods, impeding the unbiased discovery of physiological substrates in relevant model systems. Here we describe a novel method for identifying ubiquitin ligase substrates utilizing Tandem Ubiquitin Binding Entities (TUBE) technology, two-dimensional differential in gel electrophoresis (2-D DIGE), and mass spectrometry, validated by the identification of both known and novel physiological substrates of the ubiquitin ligase MuRF1 in primary cardiomyocytes. This method can be applied to any ubiquitin ligase, both in normal and disease model systems, in order to identify relevant physiological substrates under various biological conditions, opening the door to a clearer mechanistic understanding of ubiquitin ligase function and broadening their potential as therapeutic targets.
Predicting impacts of agricultural land use on stream and river biota: method review, evaluation and guidance
Creators: name: Elliott, Alexander
name: Graham, Elizabeth
name: Franklin, Paul
name: Larned, Scott
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management

description: Predicting land use and land management effects on stream and river biota is an important aspect of land-water management, yet there are no collations of what methods are available to carry out those assessments nor guidance on which methods to use. This paper summarises a range of methods with examples of their applications, comments on their strengths and weaknesses, evaluates them against a set of criteria, and provides guidance on method selection. Assessment methods include empirical statistical and mechanistic models, Bayesian Networks, likelihood-consequence risk assessments, scoring methods, and hybrid methods, some of which can be informed by expert elicitation. An evaluation matrix for methods indicated that no single method is ideal, and selection of methods needs to carefully consider factors such as the physico-chemical stressor or biotic impact of interest, the intended stakeholders, and the scales of assessment. One emergent principle is the separation of relationships between land use and stressors from assessments of stressors and biota, for which alternative methods could be used. A tiered approach is recommended, whereby simple methods with low resource and time requirements are applied first, followed by more sophisticated methods for selected aspects if needed. There is a need for more ready-made methods at the screening level, as well as development of new methods to address remaining gaps such as multiple stressors.
Measuring Activity in the Ubiquitin–Proteasome System: From Large Scale Discoveries to Single Cells Analysis
Creators: name: Waters, Marcey L.
name: Park, Jessica H.
name: Melvin, Adam T.
name: Woss, Gregery S.
name: Allbritton, Nancy L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ubiquitin proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins in addition to performing essential roles in DNA repair, cell cycle regulation, cell migration, and the immune response. While traditional biochemical techniques have proven useful in the identification of key proteins involved in this pathway, the implementation of novel reporters responsible for measuring enzymatic activity of the UPS have provided valuable insight into the effectiveness of therapeutics and role of the UPS in various human diseases such as multiple myeloma and Huntington’s disease. These reporters, usually consisting of a recognition sequences fused to an analytical handle, are designed to specifically evaluate enzymatic activity of certain members of the UPS including the proteasome, E3 ubiquitin ligases, and deubiquitinating enzymes (DUBs). This review highlights the more commonly used reporters employed in a variety of scenarios ranging from high-throughput screening of novel inhibitors to single cell microscopy techniques measuring E3 ligase or proteasome activity. Finally, recent work is presented highlighting the development of novel degron-based substrate designed to overcome the limitations of current reporting techniques in measuring E3 ligase and proteasome activity in patient samples.
A Foot in the Door to the Alternative Protein Market
Creators: name: Dickey, Delwyn
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management

description: Developing a pea and fava bean protein market in New Zealand would have high environmental gains, finds new research - but who pays for the processing plant and how to grow value for growers are questions yet to be answered.
Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen: REGULATION OF ASB4 EXPRESSION IN ENDOTHELIAL CELL LINES
Creators: name: Lockyer, Pamela
name: Patterson, Cam
name: Wu, Yaxu
name: Portbury, Andrea L.
name: Dechyapirom, Weeranun
name: Pi, Xinchun
name: Bode, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: During vascular development, endothelial cells are exposed to a variety of rapidly changing factors, including fluctuating oxygen levels. We have previously shown that Ankyrin Repeat and SOCS Box Protein 4 (ASB4) is the most highly differentially expressed gene in the vascular lineage during early differentiation and is expressed in the embryonic vasculature at a time when oxygen tension is rising due to the onset of placental blood flow. In order to further our understanding of the regulation of ASB4 expression in endothelial cells, we tested the effect of various stressors for their ability to alter ASB4 expression in the immortalized murine endothelial cell lines MS1 and SVR. ASB4 expression is decreased during hypoxic insult and shear stress whereas it is increased in response to TNF-α. Further investigation indicated that Nuclear Factor kappa B (NF-κB) is the responsible transcription factor involved in the TNF-α-induced upregulation of ASB4, placing ASB4 downstream of NF-κB in the TNF-α signaling cascade and identifying it as a potential regulator for TNF-α’s numerous functions associated with inflammation, angiogenesis and apoptosis.
(401683) Catherine Stewart
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Electron density images generated using a transfer learning technique with a denoising convolutional neural network
Creators: name: Shiotsuki, Kenshi
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CT
subject: Computer Applications-General
subject: Technical aspects
subject: Image verification

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Electron density (ED) is used to calculate dose distributions by radiation therapy planning devices [1] and ca help differentiate high grade glioma from low grade glioma [2]. Thus, ED is greatly related to radiotherapy and diagnosis but can be...
title: Accuracy of dose calculation in stereotactic radiotherapy for the head: A comparison between single-energy and dual-energy computed tomography
Creators: name: Shiotsuki, Kenshi
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: CT
subject: Stereotactic radiotherapy
subject: Image guided radiotherapy
subject: Metastases
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The relationship between the CT value and electron density for the subject is important in radiation therapy planning. This relationship is created by the known relative electron densities and measured CT values of various human equivalent materials...
Muscle Ring Finger 1 (MuRF1) and MuRF2 are Necessary but Functionally Redundant During Developmental Cardiac Growth and Regulate E2F1-Mediated Gene Expression In Vivo
Creators: name: Rodríguez, Jessica E.
name: Wadosky, Kristine M.
name: Glass, David J.
name: Hilliard, Eleanor G.
name: Willis, Monte S.
name: Schisler, Jonathan C.
name: Lockyer, Pamela
name: Patterson, Cam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Muscle ring finger (MuRF) proteins have been implicated in the transmission of mechanical forces to nuclear cell signaling pathways through their association with the sarcomere. We recently reported that MuRF1, but not MurF2, regulates pathologic cardiac hypertrophy in vivo. This was surprising given that MuRF1 and MuRF2 interact with each other and many of the same sarcomeric proteins experimentally.
(401684) George Stratton Blakemore
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
AI & Ethics Roundtable with Bit Prototyping Studio
Creators: name: Giaccardi, Elisa
name: Yurrita, Mireia
name: Yuxi Liu
name: Turtle, Grace
Publisher: name: Zenodo
Year: 2023

description: Presentation given to introduce the DCODE Network as part of the AI & Ethics Roundtable held with the BIT prototyping studio
Filamentary Switching: Synaptic Plasticity through Device Volatility
Creators: name: La Barbera, Selina
name: Vuillaume, Dominique
name: Alibart, Fabien
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Replicating the computational functionalities and performances of the brain remains one of the biggest challenges for the future of information and communication technologies. Such an ambitious goal requires research efforts from the architecture level to the basic device level (i.e., investigating the opportunities offered by emerging nanotechnologies to build such systems). Nanodevices, or, more precisely, memory or memristive devices, have been proposed for the implementation of synaptic functions, offering the required features and integration in a single component. In this paper, we demonstrate that the basic physics involved in the filamentary switching of electrochemical metallization cells can reproduce important biological synaptic functions that are key mechanisms for information processing and storage. The transition from short- to long-term plasticity has been reported as a direct consequence of filament growth (i.e., increased conductance) in filamentary memory devices. In this paper, we show that a more complex filament shape, such as dendritic paths of variable density and width, can permit the short- and long-term processes to be controlled independently. Our solid-state device is strongly analogous to biological synapses, as indicated by the interpretation of the results from the framework of a phenomenological model developed for biological synapses. We describe a single memristive element containing a rich panel of features, which will be of benefit to future neuromorphic hardware systems.
title: Sign Language in Musculoskeletal Radiology
Creators: name: Valgaeren, Bjorn
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal joint
subject: Musculoskeletal spine
subject: CT
subject: Digital radiography
subject: MR
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Medical images do not have to be hard to understand. To make it easier to recognize certain pathology, we made this poster. The goal of this poster is increasing knowledge of musculoskeletal pathology by showing multiple convenient and...
The $\infty$-Besov Capacity Problem
Creators: name: Milman, Mario
name: Xiao, Jie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 31C15, 35J92, 42B37, 46E35

description: A theory of $\infty$-Besov capacities is developed and several applications are provided. In particular, we solve an open problem in the theory of limits of the $\infty$-Besov semi-norms, we obtain new restriction-extension inequalities and we characterize the point-wise multipliers acting on the $\infty$-Besov spaces.
description: 17 pages made some corrections
A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity
Creators: name: Treves, Susan
name: Vukcevic, Mirko
name: Meissner, Gerhard
name: Ghassemi, Farshid
name: Zorzato, Francesco
name: Jungbluth, Heinz
name: Muntoni, Francesco
name: Xu, Le
name: Zhou, Haiyan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by releasing calcium ions required for muscle contraction from the sarcoplasmic reticulum. At least three phenotypes associated with more than 100 RYR1 mutations have been identified; in order to elucidate possible pathophysiological mechanisms of RYR1 mutations linked to neuromuscular disorders, it is essential to define the mutation class by studying the functional properties of channels harboring clinically relevant amino acid substitutions. In the present report we investigated the functional effects of the c.7304G>T RYR1 substitution (p.Arg2435Leu) found in a patient affected by central core disease. Both parents were heterozygous for the substitution while the proband was homozygous. We characterized Ca2+ homeostasis in myoD transduced myotubes from controls, the heterozygous parents and the homozygous proband expressing the endogenous mutation. We also expressed the recombinant mutant channels in heterologous cells and characterized their [3H]ryanodine binding and single channel properties. Our results show that the p.Arg2435Leu substitution affects neither the resting [Ca2+], nor the sensitivity of the ryanodine receptor to pharmacological activators, but rather reduces the release of Ca2+ from intracellular stores induced by pharmacological activators as well as by KCl via the voltage sensing dihydropyridine receptor.
Note on regular black holes in a brane world
Creators: name: Neves, J. C. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work, we show that regular black holes in a Randall-Sundrum-type brane world model are generated by the nonlocal bulk influence, expressed by a constant parameter in the brane metric, only in the spherical case. In the axial case (black holes with rotation), this influence forbids them. A nonconstant bulk influence is necessary to generate regular black holes with rotation in this context.
description: 5 pages, version accepted in PRD with two new subsections
(401679) William Duncan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401681) david Watson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma.
Creators: name: Lafleur, Véronique N
name: Halim, Silvia
name: Choudhry, Hani
name: Ratcliffe, Peter J
name: Mole, David R
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Biochemistry & Proteomics
Metabolism
Cell Biology
Signalling & Oncogenes

description: Hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AHR) are members of the bHLH-PAS family of transcription factors that underpin cellular responses to oxygen and to endogenous and exogenous ligands, respectively, and have central roles in the pathogenesis of renal cancer. Composed of heterodimers, they share a common HIF-1β/ARNT subunit and similar DNA-binding motifs, raising the possibility of crosstalk between the two transcriptional pathways. Here, we identify both general and locus-specific mechanisms of interaction between HIF and AHR that act both antagonistically and cooperatively. Specifically, we observe competition for the common HIF-1β/ARNT subunit, in cis synergy for chromatin binding, and overlap in their transcriptional targets. Recently, both HIF and AHR inhibitors have been developed for the treatment of solid tumours. However, inhibition of one pathway may promote the oncogenic effects of the other. Therefore, our work raises important questions as to whether combination therapy targeting both of these pro-tumourigenic pathways might show greater efficacy than targeting each system independently.
A Critical Analysis of the Feasibility of Pure Strain-Actuated Giant Magnetostrictive Nanoscale Memories
Creators: name: Gowtham, Praveen G.
name: Rowlands, Graham E.
name: Buhrman, Robert A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Concepts for memories based on the manipulation of giant magnetostrictive nanomagnets by stress pulses have garnered recent attention due to their potential for ultra-low energy operation in the high storage density limit. Here we discuss the feasibility of making such memories in light of the fact that the Gilbert damping of such materials is typically quite high. We report the results of numerical simulations for several classes of toggle precessional and non-toggle dissipative magnetoelastic switching modes. Material candidates for each of the several classes are analyzed and forms for the anisotropy energy density and ranges of material parameters appropriate for each material class are employed. Our study indicates that the Gilbert damping as well as the anisotropy and demagnetization energies are all crucial for determining the feasibility of magnetoelastic toggle-mode precessional switching schemes. The roles of thermal stability and thermal fluctuations for stress-pulse switching of giant magnetostrictive nanomagnets are also discussed in detail and are shown to be important in the viability, design, and footprint of magnetostrictive switching schemes.
description: 30 pages main text + 11 figures
title: The role of MR imaging in retinoblastoma
Creators: name: Jadib, Abdelhamid
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Eyes
subject: Neuroradiology brain
subject: Paediatric
subject: MR
subject: Diagnostic procedure
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: List MR imaging sequences and protocol for the assessment of retinoblastoma Describe retinoblastoma features on MR imaging Discuss the key features that impact prognosis and...
Notes on the morphological diversity, ethnobotanical uses, and conservation of Citrus hongheensis (Rutaceae): an endemic and endangered Papeda from southwest China
Creators: name: Mou, Feng-Juan
name: Li, Jian-Qin
name: Li, Yue-Yan
name: Meng, Ting-Yao
name: Han, Shun-Long
Publisher: name: figshare
Year: 2023
Subjects: Other agricultural, veterinary and food sciences not elsewhere classified

description: One table and five figures.
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
Creators: name: Fulton, Timothy R.
name: Li, Xinghai
name: Wang, Ying
name: Duan, Hongzhe
name: Eu, Jerry P.
name: Meissner, Gerhard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely understood. Here we report that delivery of siRNAs specific for triadin or junctin into C2C12 skeletal myoblasts reduced the expression of triadin and junctin in 8-day-old myotubes by 80 and 100%, respectively. Knocking down either triadin or junctin in these cells reduced Ca2+ release induced by depolarization (10 mM KCl) by 20–25%. Unlike triadin knockdown myotubes, junctin knockdown and junctin/triadin double knockdown myotubes also had reduced Ca2+ release induced by 400 μM 4-chloro-m-cresol, 10 mM caffeine, 400 μM UTP, or 1 μM thapsigargin. Thus, knocking down junctin compromised the Ca2+ stores in the sarcoplasmic reticulum of these cells. Our subsequent studies showed that in junctin knockdown myotubes at least two sarcoplasmic reticulum proteins (RyR1 and skeletal muscle calsequestrin) were down-regulated while these proteins’ mRNA expression was not affected. The results suggest that triadin has a role in facilitating KCl depolarization-induced Ca2+ release in contrast to junctin which has a role in maintaining sarcoplasmic reticulum Ca2+ store size in C2C12 myotubes.
Cardiac Progenitors and the Embryonic Cell Cycle
Creators: name: Goetz, Sarah C.
name: Conlon, Frank L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Despite the critical importance of proper cell cycle regulation in establishing the correct morphology of organs and tissues during development, relatively little is known about how cell proliferation is regulated in a tissue-specific manner. The control of cell proliferation within the developing heart is of considerable interest, given the high prevalence of congenital cardiac abnormalities among humans, and recent interest in the isolation of cardiac progenitor populations. We therefore review studies exploring the contribution of cell proliferation to overall cardiac morphology and the molecular mechanisms regulating this process. In addition, we also review recent studies that have identified progenitor cell populations within the adult myocardium, as well as those exploring the capability of differentiated myocardial cells to proliferate post-natally. Thus, the exploration of cardiomyoctye cell cycle regulation, both during development as well as in the adult heart, promises to yield many exciting and important discoveries over the coming years.
title: MR imaging of neurovascular compression syndromes in the cerebellopontine angle
Creators: name: Jadib, Abdelhamid
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: MR-Angiography
subject: Diagnostic procedure
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: List MR imaging recommendations for the assessment of neurovascular compression syndrome Describe MR imaging key features used for the diagnosis of neurovascular compression...
title: Negative multiparametric magnetic resonance imaging of the prostate in biopsy-naïve men and men after negative prostate biopsy - is there any difference in ADC values?
Creators: name: Spirovski, Milena
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system male
subject: MR-Diffusion/Perfusion
subject: Comparative studies
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Multiparametric magnetic resonance imaging (mpMRI) is recommended in men with clinical suspicion of prostate cancer. For more than a decade it was limited to men after a negative prostate biopsy and persistent clinical suspicion of prostate cancer,...
title: Triple Rule Out CT Angiography in acute chest pain: how to perform it successfully?
Creators: name: Noureddine, Leila
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiovascular system
subject: Thorax
subject: Vascular
subject: CT
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Acute
subject: Dissection
subject: Embolism / Thrombosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Acute chest pain can have various urgent diagnostic orientations, which can rapidly engage the vital prognosis, especially in older patients with comorbidities. Our aim is to remind young radiologists of the Triple Rule Out (TRO) technique and its...
title: Title: Pre-procedural imaging of atrial septal defect closure; what the radiologist should know?
Creators: name: CHETOUI, MARYEM
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT-Angiography
subject: Echocardiography (transoesophageal)
subject: Fluoroscopy
subject: Contrast agent-intravenous
subject: Segmentation
subject: Cardiac Assist Devices
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the embryology, pathophysiology, and clinical history of the atrial septal defect (ASD).To demonstrate the place of cardiac MRI and coronary computed tomography (CT) angiography in the pre-procedural imaging of ASD.To learn the protocols...
title: Computed tomographic prognostic factors of stapes surgery for otosclerosis.
Creators: name: kammoun, nadhem
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: CT
subject: Comparative studies
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Otosclerosis is an osteodystrophy of the otic capsule, responsible for deafness due to a blockage of the stapes at the vestibular window. The diagnosis of this condition is suspected on the basis of clinical and audiometric data and confirmed...
title: Endoleaks associated with fenestrated branched endovascular aortic repair (F-BEVAR) in the treatment of thoraco-abdominal aortic aneurysms and complex abdominal aortic aneurysms
Creators: name: Tintaya, Benjamin
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Vascular
subject: CT
subject: CT-Angiography
subject: Embolisation
subject: Stents
subject: Aneurysms

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the new classification of endoleaks associated with the use of fenestrated and branched endoprostheses (F-BEVAR). To describe examples of each of them with cases from our experience. To review the different treatments for each...
Identification of Primary Transcriptional Regulation of Cell Cycle-Regulated Genes upon DNA Damage
Creators: name: Paules, Richard S.
name: Hurban, Patrick
name: Mullen, Thomas E.
name: Bushel, Pierre R.
name: Zhou, Yingchun
name: Zhou, Tong
name: Chou, Jeff
name: Simpson, Dennis A.
name: Lobenhofer, Edward K.
name: Elkon, Rani
name: Kaufmann, William K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the expression levels of >400 cell cycle-regulated genes in normal human fibroblasts based on the proportions of cells in each phase of the cell cycle. By isolating effects on the gene expression associated with the cell cycle phase redistribution after genotoxin treatment, the direct transcriptional target genes were distinguished from genes for which expression changed secondary to cell synchronization. Application of this model to ionizing radiation (IR)-treated normal human fibroblasts identified 150 of 406 cycle-regulated genes as putative direct transcriptional targets of IR-induced DNA damage. Changes in expression of these genes after IR treatment derived from both direct transcriptional regulation and cell cycle synchronization.
(401677) David Small
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Direct measurements of the extraordinary optical momentum and transverse spin-dependent force using a nano-cantilever
Creators: name: Antognozzi, M.
name: Bermingham, C. R.
name: Harniman, R. L.
name: Simpson, S.
name: Senior, J.
name: Hayward, R.
name: Hoerber, H.
name: Dennis, M. R.
name: Bekshaev, A. Y.
name: Bliokh, K. Y.
name: Nori, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Known since Kepler's observation that a comet's tail is oriented away from the sun, radiation pressure stimulated remarkable discoveries in electromagnetism, quantum physics and relativity [1,2]. This phenomenon plays a crucial role in a variety of systems, from atomic [3-5] to astronomical [6] scales. The pressure of light is associated with the momentum of photons, and it is usually assumed that both the optical momentum and the radiation-pressure force are naturally aligned with the propagation of light, i.e., its wavevector. Here we report the direct observation of an extraordinary optical momentum and force directed perpendicular to the wavevector, and proportional to the optical spin (i.e., degree of circular polarization). Such optical force was recently predicted for evanescent waves [7] and other structured fields [8]. It can be associated with the enigmatic "spin-momentum" part of the Poynting vector, which was introduced by Belinfante in field theory 75 years ago [9-11]. We measure this unusual transverse momentum using a nano-cantilever capable of femto-Newton resolution, which is immersed in an evanescent optical field above the total-internal-reflecting glass surface. Furthermore, the transverse force we measure exhibits another polarization-dependent contribution determined by the imaginary part of the complex Poynting vector. By revealing new types of optical forces in structured fields, our experimental findings revisit fundamental momentum properties of light and bring a new twist to optomechanics.
description: 9 pages, 3 figures, Supplementary Information
(401678) John Stewart
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: HEMORRHAGIC OVARIAN CYSTS IN PEDIATRIC AGE: Ultrasonographic findings and clues for differential diagnosis.
Creators: name: Veiga Canuto, Diana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Paediatric
subject: MR
subject: Ultrasound
subject: Education
subject: eLearning
subject: Cysts

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the different forms of clinical presentation, ultrasound findings and management of hemorrhagic ovarian cysts, providing ultrasound clues for its differential diagnosis with other pediatric adnexal...