cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of optical projection tomography for mesoscopic 3-D biomedical imaging
Creators: name: Chen, Lingling
Publisher: name: Imperial College London
Year: 2013

description: Optical projection tomography (OPT) is an exciting technique for imaging “mesoscopic” (1 – 10 mm) samples at a high resolution, providing three-dimensional (3-D) absorption and/or fluorescence distributions of chromophores in optically transparent specimens. This thesis describes the study, development and application of OPT technology for potential applications in biomedical research including developmental biology, tissue analysis (e.g. for histopathology), the study of disease mechanisms and therapies, dosimetry and drug discovery. The thesis begins with an introduction to fluorescence, fluorescence lifetime imaging (FLIM) and OPT and then describes the experimental configurations and characterisation of in-house developed intensity-based OPT instruments. Using the measured characteristics of specific OPT set-ups, different tomographic reconstruction approaches for OPT are investigated through modelling and experiments and the achievable image quality and speed are compared to the performance obtained with the standard reconstruction algorithm. The development of OPT using a novel angular multiplexing technique is then discussed. This employs multiple imaging systems in parallel that can acquire OPT data sets simultaneously. Their performances using different focusing arrangements to image either shifted focal planes or a common focal plane in the sample is investigated and shown to provide faster imaging with improved spatial resolution. The latter configuration is demonstrated to offer the capability to track feature motions such as cell trajectories with a time lapse resolution limited by the frame rate of the cameras and to provide 3-D feature tracking with significantly reduced light dose compared to standard OPT. The application of OPT and its extension to incorporate wide-field time-gated FLIM, referred as FLIM-OPT, to a range of biological specimens is then discussed, including fixed and chemically cleared tissues and live animal models. These experiments demonstrate the efficacy of OPT as a 3-D imaging tool for biomedical research. The potential efficacy of FLIM-OPT to read out Förster resonance energy transfer (FRET) is then demonstrated, including in live zebrafish embryos. Thus OPT is shown to provide a 3-D tomographic imaging technique able to yield structural and functional information in intact organisms.
Glue Ball Masses and the Chameleon Gauge
Creators: name: Marinari, E.
name: Paciello, M. L.
name: Parisi, G.
name: Taglienti, B.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce a new numerical technique to compute mass spectra, based on difference method and on a new gauge fixing procedure. We show that the method is very effective by test runs on a $SU(2)$ lattice gauge theory.
description: latex format, 10 pages, 4 figures added in uufiles format
Deep HST Observations of Star Clusters in NGC 1275
Creators: name: Carlson, Matthew N.
name: Holtzman, Jon A.
name: Watson, Alan M.
name: Grillmair, Carl J.
name: Mould, Jeremy R.
name: Team, the WFPC2 Investigation Definition
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present an analysis of compact star clusters in deep HST/WFPC2 images of NGC 1275. B and R band photometry of roughly 3000 clusters shows a bimodality in the B-R colors, suggesting that distinct old and young cluster populations are present. The small spread in the colors of the blue clusters is consistent with the hypothesis that they are a single age population, with an inferred age of 0.1 to 1 Gyr. The luminosity function shows increasing numbers of blue clusters to the limit of our photometry, which reaches several magnitudes past the turnover predicted if the cluster population were identical to current Galactic globulars seen at a younger age. The blue clusters have a spatial distribution which is more centrally peaked than that of the red clusters. The individual clusters are slightly resolved, with core radii
description: 26 pages, 9 figures, to be published in the Astronomical Journal
MOESM6 of Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8
Creators: name: Tsusaka, Takeshi
name: Kikuchi, Masaki
name: Shimazu, Tadahiro
name: Suzuki, Takehiro
name: Sohtome, Yoshihiro
name: Akakabe, Mai
name: Sodeoka, Mikiko
name: Naoshi Dohmae
name: Umehara, Takashi
name: Shinkai, Yoichi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 6: Fig. S4. Representative SPR sensorgram (left) and affinity curves (right) of human G9a binding to immobilized human histone H3, ATF7IP and LIG1 peptide. G9a was injected over the sensor chip immobilized with (A) unmodified H3, (B) H3K9me1, (C) H3K9me2, (D) H3K9me3, (E) unmodified ATF7IP, (F) ATF7IP K16me1, (G) ATF7IP K16me2, (H) ATF7IP K16me3, (I) unmodified LIG1, (J) LIG1 K126me1, (K) LIG1 K126me2, and (L) LIG1 K126me3 peptides (related to Fig.Â 4).
Studies on the mechanism of norovirus RNA synthesis
Creators: name: Yunus, Muhammad Amir
Publisher: name: Imperial College London
Year: 2012

description: Noroviruses are common pathogens associated with gastroenteritis in humans. As single-stranded positive-sense RNA viruses, noroviruses achieve their genome replication through the synthesis of negative strand RNA intermediates that template the generation of new positive strand RNA genomes. The murine norovirus (MNV) RNA-dependent RNA polymerase (NS7) protein which is a key player in catalysing this process, has been characterised in this study. Tandem affinity purification of MNV NS7 was performed in order to identify host cell factors which interact with the NS7 protein. Proteomic analysis demonstrated that guanosine monophosphate reductase and N(2)- dimethylguanosine tRNA methyltransferase could potentially interact with the MNV NS7. Furthermore, affinity selection of small peptides which specifically bind to the NS7 was carried out by using the phage display technique in an effort to generate peptide inhibitors. Peptide phage with two different conserved motifs and several peptide phage pools with binding activity to the NS7 were successfully identified. However, further cross-binding analysis using ELISA demonstrated that these peptide phage possibly bound non-specifically to the MNV NS7. An optimised RNA based reverse genetics system and reporter-tagged replicon system for MNV were also successfully developed and used to quantify the effects of specific mutations in the MNV genome on viral replication in tissue culture. Using these newly developed systems, the functional role of a small stem loop structure located upstream of the start site of the subgenomic RNA was characterised. This was identified as the potential viral RNA polymerase promoter responsible for subgenomic RNA synthesis. Furthermore, identification and characterisation of this stem loop using mutations suggested the potential involvement of long range RNA-RNA interactions (on negative strand RNA) in regulating the norovirus subgenomic RNA synthesis. Overall, this study has unveiled the importance of protein-protein interactions and RNA-protein interactions in regulating norovirus replication. These interactions could provide interesting targets for antiviral therapeutic intervention in the future.
Detecting Mammals in UAV Images: Best Practices to address a substantially Imbalanced Dataset with Deep Learning
Creators: name: Kellenberger, Benjamin
name: Marcos, Diego
name: Tuia, Devis
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Knowledge over the number of animals in large wildlife reserves is a vital necessity for park rangers in their efforts to protect endangered species. Manual animal censuses are dangerous and expensive, hence Unmanned Aerial Vehicles (UAVs) with consumer level digital cameras are becoming a popular alternative tool to estimate livestock. Several works have been proposed that semi-automatically process UAV images to detect animals, of which some employ Convolutional Neural Networks (CNNs), a recent family of deep learning algorithms that proved very effective in object detection in large datasets from computer vision. However, the majority of works related to wildlife focuses only on small datasets (typically subsets of UAV campaigns), which might be detrimental when presented with the sheer scale of real study areas for large mammal census. Methods may yield thousands of false alarms in such cases. In this paper, we study how to scale CNNs to large wildlife census tasks and present a number of recommendations to train a CNN on a large UAV dataset. We further introduce novel evaluation protocols that are tailored to censuses and model suitability for subsequent human verification of detections. Using our recommendations, we are able to train a CNN reducing the number of false positives by an order of magnitude compared to previous state-of-the-art. Setting the requirements at 90% recall, our CNN allows to reduce the amount of data required for manual verification by three times, thus making it possible for rangers to screen all the data acquired efficiently and to detect almost all animals in the reserve automatically.
Lattice Schwinger Model with interpolated Gauge Fields
Creators: name: Gattringer, Christof
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze the Schwinger model on an infinite lattice using the continuum definition of the fermion determinant and a linear interpolation of the lattice gauge fields. The possible class of interpolations for the gauge fields, compatible with gauge invariance is discussed. The effective action for the lattice gauge field is computed for the Wilson formulation as well as for non-compact lattice gauge fields. For the non-compact formulation we prove that the model has a critical point with diverging correlation length at zero gauge coupling e. We compute the chiral condensate for e > 0 and compare the result to the N-flavor continuum Schwinger model. This indicates that there is only one flavor of fermions with the same chiral properties as in the continuum model, already before the continuum limit is performed. We discuss how operators have to be renormalized in the continuum limit to obtain the continuum Schwinger model.
description: 14 pages
Oral history interview with Luther H. Foster 1981
Publisher: name: Columbia University
Year: 2019
Subjects: College presidents
African Americans--Education
African Americans--Social conditions

description: Educational background; business manager, 1941-1953, President, from 1953, of Tuskegee Institute; budget, relations with other black colleges; United Negro College Fund: organizational hierarchy, responsibilities, fund raising activities.
Studies of ionic mechanisms associated with human cancers
Creators: name: Guzel, Refika Mine
Publisher: name: Imperial College London
Year: 2012

description: The general aim of this thesis was to undertake a series of inter-related studies with a view to improving our understanding of the role of ion channel expression and its regulation in cancer cells with strong metastatic potential. The emphasis was on neonatal Nav1.5 (nNav1.5) subtype of voltage-gated sodium channel (VGSC). Chapter 1 (General Introduction) gives an account of the relevant literature and states the main aims of the studies. Chapter 2 details the Materials and Methods, ranging from quantitative molecular biology to in vitro assays of metastatic cell behaviour. Chapter 3 presents experiments on regulation of VGSCs by insulin and insulin-like growth factor1 (IGF1) in strongly metastatic human breast cancer (BCa) MDA-MB- 231 cells. The central strategy was to treat insulin and IGF1 as an integrated signalling system (”IIS”) and suppress it using pharmacological inhibitors and RNAi. Inhibiting IIS signalling suppressed metastatic cell behaviours (MCBs) and decreased nNav1.5 expression and activity. Chapter 4 describes studies on mRNA expression of a variety of cancer-associated ion channels (CAICs) in peripheral blood of normal human subjects with a view to laying the foundations for subsequent patient-based studies. The following 8 CAICs were studied: nNav1.5, VGSC-β1, VGSC-β1b, Kv1.3, Kv10.1, Kv11.1, KCa3.1 and TRPM8. Several differences were noted between healthy cases and cancer patients. In particular, nNav1.5 and Kv1.3 mRNA expressions were up- and down-regulated, respectively. Chapter 5 shows that the anti-diabetic drug Metformin suppressed Matrigel invasion and nNav1.5 mRNA expression in MDA-MB-231 cells. Chapter 6 involves studies on the strongly metastatic human colorectal cancer (CRCa) SW-620 cells, which were found to express nNav1.5 mRNA and protein. Silencing nNav1.5 expression had a significant inhibitory effect on Matrigel invasion. The thesis ends with a General Discussion and Conclusion chapter, integrating the findings in the context of the field at large and pointing to future directions.
Causality of Massive Spin 2 Field in External Gravity
Creators: name: Buchbinder, I. L.
name: Gitman, D. M.
name: Pershin, V. D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the structure of equations of motion and lagrangian constraints in a general theory of massive spin 2 field interacting with external gravity. We demonstrate how consistency with the flat limit can be achieved in a number of specific spacetimes. One such example is an arbitrary static spacetime though equations of motion in this case may lack causal properties. Another example is provided by external gravity fulfilling vacuum Einstein equations with arbitrary cosmological constant. In the latter case there exists one-parameter family of theories describing causal propagation of the correct number of degrees of freedom for the massive spin 2 field in arbitrary dimension. For a specific value of the parameter a gauge invariance with a vector parameter appears, this value is interpreted as massless limit of the theory. Another specific value of the parameter produces gauge invariance with a scalar parameter and this cannot be interpreted as a consistent massive or massless theory.
description: LaTeX, 13 pages, an example of a non-Einstein spacetime preserving consistency with the flat limit added
Advanced damage modelling of free machining steels
Creators: name: Kaye, Michael
Publisher: name: Imperial College London
Year: 2012

description: The current available damage models do not accurately predict effective plastic strain to failure in low triaxiality stress states. A damage model was developed for low triaxiality that is appropriate to hot rolling of steel. This work focuses on nucleation and growth of damage as well as the effect of the strain and stress path. The latter is especially important for the rolling of bar and other complex cross-section products. A study of damage mechanisms and methods to model them has been undertaken. It is pointed out that the many models are only useful under certain conditions but can be used when the expected damage mechanisms are active. Several test types were evaluated to assess their ability to simulate stress state in rolling. A program has been written to evaluate the stress state for plane and axisymmetric tests, which allows one to choose the most appropriate test-piece geometry. A test has been designed and implemented. Thermal and mechanical data was gathered, which has been used to relate the stress triaxiality to damage growth and identify appropriate damage growth models. The size and spacing distributions of inclusions in free cutting steels have been measured. The different distributions have an effect on the ductility of the different steels. This effect has been found to change at different strain rates and temperatures. By better accounting for the effect of inclusions on damage growth under a range of test conditions, the damage model can be significantly improved. Free cutting steels that contained different additions of heavy metals were tested. The ductility and damage mechanisms were compared in each of the steels. The effect of the precipitation of the different heavy metals at the inclusion to matrix boundary was highlighted. The same damage mechanisms were observed in each steel but the ability to accommodate damage varied between the steels. Ex-situ synchrotron x-ray micro-tomography was used to better measure and quantify the distribution of inclusions and damage evolution in a free cutting steel. Localised damage coalescence away from the centre of the uniaxial tensile test-piece was attributed to the effect of inclusion clustering. This research was used to develop a realistic damage model, which can predict damage growth and coalescence for a range of forming parameters and different stress-state conditions related to hot rolling applications. The micro-mechanics based model includes the effects of inclusion distribution on damage. The model is calibrated using twenty six temperature based material constants.
Oral history interview with Luther H. Evans, 1970
Publisher: name: Columbia University
Year: 2020
Subjects: Librarians
Educators
New Deal, 1933-1939
International agencies

description: Works Progress Administration, Historical Records Survey; Library of Congress, 1939 and 1945; UNESCO, 1949-58; first meeting with Dwight D. Eisenhower as President of Columbia University
Effects of forest fire severity on terrestrial carbon emission and ecosystem production in the Himalayan region, India
Creators: name: Sannigrahi, Srikanta
name: Bhatt, Sandeep
name: Rahmat, Shahid
name: Rana, Virendra
name: Chakraborti, Suman
Publisher: name: arXiv
Year: 2018
Subjects: subject: Other Quantitative Biology (q-bio.OT)
subject: FOS: Biological sciences

description: Remote sensing techniques have been used effectively for measuring the overall loss of terrestrial ecosystem production and biodiversity due to the forest fire. The current research focuses on assessing the impact of forest fire severity on terrestrial ecosystem productivity using different burn indices in Uttarakhand, India. Satellite-based land surface temperature (LST) was calculated for pre-fire (2014) and fire (2016) year using MODerate Resolution Imaging Spectroradiometer (MODIS) to identify the burn area hotspots across all eco-regions in Uttarakhand. In this study, spatial and temporal changes of different vegetation and burn area indices i.e Normalized Burn Ratio (NBR), Burnt Area Index (BAI), Normalized Multiband Drought Index (NMDI), Soil Adjusted Vegetation Index (SAVI), Global Environmental Monitoring Index (GEMI), Enhanced Vegetation Index (EVI), Normalized Difference Vegetation Index (NDVI)were estimated for both pre-fire and fire years. Additionally, two Light Use Efficiency (LUE) models i.e Carnegie- Ames-Stanford-Approach (CASA) and Vegetation Photosynthesis Model (VPM) were selected to quantify the terrestrial Net Primary Productivity (NPP) in pre-fire and fire years across all biomes of the study area.The present approach appears to be promising and has a potential in quantifying the loss of ecosystem productivity due to forest fires. A detailed field observation data is required for further training, and testing of remotely sensed fire maps for future research.
MOESM1 of Life beyond the Tanimoto coefficient: similarity measures for interaction fingerprints
Creators: name: Rácz, Anita
name: Bajusz, Dávid
name: Héberger, Károly
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Additional file 1. Supplementary information.
A note on D-branes in group manifolds: flux quantisation and D0-charge
Creators: name: Stanciu, Sonia
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that a D-brane in a group manifold given by a (twisted) conjugacy class is characterised by a gauge invariant two-form field determined in terms of the matrix of gluing conditions. Using a quantisation argument based on the path integral one obtains the known quantisation condition for the corresponding D-branes. We find no evidence for the existence of a quantised U(1) gauge field flux. We propose an expression for the D0 charge of such D-branes.
description: 13 pages. (v2: minor changes, some comments and references added.)
title: Valérie Laloux, Cédric Tolley, "VIH Sida : bientôt la fin de l'épidémie ?"
Creators: name: Laloux, Valérie
name: Tolley, Cédric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Extrait de Echos, no 87.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111232830360
description: created: start=2010;end=2017
RXTE Observations of GX 3+1
Creators: name: Strohmayer, Tod E.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We summarize new RXTE observations to search for millisecond X-ray variability from the bright Galactic bulge source GX 3+1. During a short 2 ksec observation we did not detect kilohertz (kHz) quasiperiodic oscillations (QPO). We place an upper limit of about 1 % (rms) on the amplitude of such oscillations.
description: 4 pages, Latex AIP Proceedings, 1997 October Astrophysics Conference in Maryland: "Accretion Processes in Astrophysics, Some Like it Hot"
S^3 Skyrmions and the Rational Map Ansatz
Creators: name: Krusch, Steffen
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This paper discusses multi-skyrmions on the 3-sphere with variable radius L using the rational map ansatz. For baryon number B = 3,...,9 this ansatz produces the lowest energy solutions known so far. By considering the geometry of the model we find an approximate analytic formula for the shape function. This provides an insight why skyrmions have a shell-like structure.
description: 27 pages, 14 figures, minor corrections, references updated
Oral history interview with Luther Harris Evans, 1965
Publisher: name: Columbia University
Year: 2021
Subjects: Government executives--United States
Librarians
Educators
New Deal, 1933-1939
International agencies
Library science--Societies, etc
Political refugees

description: Early life and education: University of Texas, Stanford, Yale, Pennsylvania Military College; instructor at New York University, Dartmouth, Princeton; Works Progress Administration, 1935-1939; director of Historical Records Survey; director of Legislative Reference Service; Librarian of Congress, 1945-1953; new projects, programs; establishment of Council of National Library Association; United Nations Education, Scientific, and Cultural Organization (UNESCO): United States National Commission, 1946; Executive Board, 1949, director-general, 1953, delegate to General Conference, 1947-1951; UNESCO program development: education, agriculture, mass communication, financial aid; Brookings Institution; National Education Association; automation project; United States Commission for Refugees; American Civil Liberties Union. Impressions of Harry Hopkins, Archibald MacLeish, Torres Bodet, Henry Cabot Lodge, Dag Hammarskjold, Lyndon Johnson
title: The acceptance of mobile payments in the German retail market
Creators: name: Schuster, Oliver
name: Falkenreck, Christine
name: Wagner, Ralf
Publisher: name: Universität Kassel
Year: 2016
Subjects: subject: mobile payment
subject: technology acceptance
subject: merchant adoption
subject: TAM
subject: user satisfaction theory
subject: 330
subject: Deutschland
subject: Bargeldloser Zahlungsverkehr
subject: Verbraucherzufriedenheit
subject: Einzelhandel
subject: Akzeptanz

description: Proceedings der Konferenz "STRATEGICA : International Academic Conference – Fourth Edition" in Bucharest, Rumänien, 20.-21. Oktober 2016
title: The spiral shape of the cochlea. Transverse flow visualizations and emerging phenomena in idealized models
Creators: name: Harte, Noëlle Claudia
Publisher: name: Universität Bern
Year: 2024
Subjects: subject: 610 Medicine & health

description: The cochlea, our auditory organ, has a unique spiral shape and is fluid-filled. The physiological role of its shape remains, to a great extent, elusive and is the subject of ongoing research and debate. The curvature and torsion of the cochlear duct are most pronounced toward the apex, therefore low frequencies, which are processed there, are particularly interesting. Flow in the radial direction in the cochlea, i.e., transverse flow, is of relevance because of the microanatomy of the cochlea. This thesis aims to investigate the interplay between geometry and fluid flow, especially transverse flows, using numerical and experimental methods.
In the first part, computational fluid dynamics (CFD) simulations are performed in helical square ducts with curvature and torsion, similar to the ones observed in human cochleae. Transverse flows are examined under a harmonically oscillating axial flow for frequencies covering infrasound and low-frequency hearing, with a mean inlet velocity amplitude representing sound pressure levels from normal conversation up to the threshold of pain. Torsion significantly increases transverse flow, especially when the influence of curvature drops to negligible amounts. Interestingly, the combined effect of curvature and torsion is larger than expected from a superposition of the two.
The cochlea’s thin membranes, some as little as two cell layers thick, make the study of shear stresses, exerted by the fluid on the walls, interesting. Subsequently, the effect of geometry on wall shear stresses, and pressure fluctuations is examined numerically. The helical shape experiences the most pronounced transverse wall shear stresses at the inner wall of the curve, and its maximal wall shear stresses are higher than the sum of the maximal ones in toroidal and twisted ducts.
The second part addresses the visualization of transverse flows in millimetric ducts using an in-house developed scanning particle image velocimetry (PIV) system to capture the full flow field in a volume. Our system is adapted to small-scale oscillatory flows and allows for precise measurements of both time-resolved and net velocities. The experimental outcomes align well with the CFD simulations. The developed PIV system offers means for studying multiscale periodic flows in micro- to millimeter-scale models across a variety of applications, including biological systems like the inner ear.
The observed transverse flow phenomena offer new insights into cochlear fluid dynamics, with potential implications for metabolite transport. Further research is needed to elucidate their impact on cochlear mechanics.
title: ADCO, Grènetier de Cîteaux : comptes (1499-1503) (11 H 1173), f. 00481
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173), f. 00481, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Spectroscopy of V341 Arae: A Nearby Nova-like Variable inside a Bow-Shock Nebula
Creators: name: Bond, Howard E.
name: Miszalski, Brent
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: V341 Arae is a 10th-magnitude variable star in the southern hemisphere, discovered over a century ago by Henrietta Leavitt but relatively little studied since then. Although historically considered to be a Cepheid, it is actually blue and coincides with an X-ray source. The star lies near the edge of the large, faint Halpha nebula Fr 2-11, discovered by D. Frew, who showed that V341 Ara is actually a cataclysmic variable (CV). His deep imaging of the nebula revealed a bow-shock morphology in the immediate vicinity of the star. We have carried out spectroscopic monitoring of V341 Ara, and we confirm that it is a nova-like CV, with an orbital period of 0.15216 days (3.652 hr). We show that V341 Ara is remarkably similar to the previously known BZ Cam, a nova-like CV with a nearly identical orbital period, associated with the bow-shock nebula EGB 4. Archival sky-survey photometry shows that V341 Ara normally varies between V ~ 10.5 and 11, with a characteristic timescale ranging from about 10 to 16 days. V341 Ara lies well off-center within Fr 2-11. We speculate either that the star is undergoing a chance high-speed encounter with a small interstellar cloud, or that the nebula was ejected from the star itself in a nova outburst in the fairly distant past. At a distance of only 156 pc, V341 Ara is one of the nearest and brightest known nova-like variables, and we encourage further studies.
description: Submitted to Publications of the Astronomical Society of the Pacific
Methyltransferase like 21C interaction with Hsc70 affects chicken myoblast differentiation
Creators: name: Cheng, Jia
name: Li, Ruiqing
name: Wang, Ling
name: Zhang, Tao
name: Yuan, Guoqiang
name: Lu, Hongzhao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Skeletal muscle has an essential role in boiler production, which depends on the muscle fibre development during the embryonic stage. Whereas the posttranslational modifications of both histone and non-histone proteins are known to regulate postnatal muscle development, the biological significance of non-histone methylation is poorly understood. Recently, the methyltransferase like 21 C (METTL21C) is identified as a non-histone lysine methyltransferase whose role in chicken muscle function remains elusive. In this study, METTL21C was found by comparing free-range and caged modes in Lueyang black-boned chicken aged 60 and 120 days. Quantitative real-time PCR (qPCR) analysis demonstrated that METTL21C was mainly enriched in chicken soleus (SOL) and gastrocnemius muscle (GA) (p < .05). Meanwhile, METTL21C had a rapid increase during chicken myoblast differentiation. After METTL21C overexpression, myogenic differentiation (MyoD) and myogenin (MyoG) expression were significantly increased, indicating that METTL21C promotes chicken myoblast differentiation. Using co-immunoprecipitation (Co-IP) and liquid chromatography-mass spectrometry (LC-MS/MS) analysis, heat shock cognate 71 kDa protein (Hsc70) was confirmed to interact with METTL21C, while the effects of Hsc70 Lys-561 (Hsc70 K561) mutation suggested that Hsc70 was a METTL21C target protein. These results identify the molecular mechanism of METTL21C interaction with Hsc70 associated with chicken myoblast differentiation in the postnatal period.HighlightsThe mRNA of methyltransferase like 21C (METTL21C) was significantly increased in free-rang mode and during the chicken myoblast differentiation.Overexpression of METTL21C promoted the primary chicken myoblasts proliferation and differentiation.METTL21C could mediate the lysine methylation modification of heat shock cognate 71 kDa protein (Hsc70) to regulate the proliferation of chicken myoblasts. The mRNA of methyltransferase like 21C (METTL21C) was significantly increased in free-rang mode and during the chicken myoblast differentiation. Overexpression of METTL21C promoted the primary chicken myoblasts proliferation and differentiation. METTL21C could mediate the lysine methylation modification of heat shock cognate 71 kDa protein (Hsc70) to regulate the proliferation of chicken myoblasts.
MOESM1 of Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock
Creators: name: Ahmar Ayub
name: Ninu Poulose
name: Raghavan Raju
Publisher: name: figshare
Year: 2015
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material, approximately 459 KB.
Supplementary Material from Feather growth and quality across passerines is explained by breeding rather than moulting latitude
Creators: name: Horák, Kryštof
name: Bobek, Lukáš
name: Adámková, Marie
name: Kauzál, Ondřej
name: Kauzálová, Tereza
name: Manialeu, Judith Pouadjeu
name: Nguelefack, Télesphore Benoît
name: Nana, Eric Djomo
name: Jønsson, Knud Andreas
name: Munclinger, Pavel
name: Hořák, David
name: Sedláček, Ondřej
name: Tomášek, Oldřich
name: Albrecht, Tomáš
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: The file contains maps, additional results and supplementary figures to the main document
Ionisation Cooling Lattices for the Neutrino Factory
Creators: name: Alekou, Androula
Publisher: name: Imperial College London
Year: 2012

description: The future accelerator complex of the Neutrino Factory will have an excellent precision and outstanding discovery reach, and is therefore a facility of choice for precise neutrino oscillation measurements. In the Neutrino Factory, muons are accumulated into storage rings and decay to neutrinos. However, due to the fact that the muon beam is produced occupying a large transverse phase-space, it is essential that its emittance is decreased using ionisation cooling. The reference ionisation cooling lattice of the Neutrino Factory has a large magnetic field at the position of the RF cavities, and there is a strong concern this can lead to RF breakdown. Therefore, there lies a great necessity for alternative cooling lattices to be found. This thesis presents several cooling lattices that were designed aiming to mitigate the problem of the RF breakdown in the presence of a magnetic field, that the reference lattice suffers from. In particular, amongst these lattices, a promising new configuration which makes use of a pair of opposite polarity and homocentric coils, named “Bucked Coils”, is presented. The Bucked Coils lattice not only manages to successfully achieve a virtually zero longitudinal magnetic field at the position of the RF cavities, but also obtains a better transmission than the reference lattice. A detailed comparison between the reference and the new lattices is presented with respect to the magnetic field, transmission and cooling efficiency. A possible extension of the work is also discussed. A six-dimensional cooling could be used at a Neutrino Factory but is essential for a Muon Collider. Another novel configuration, which aims to achieve 6D ionisation cooling, is presented in this thesis. This new lattice creates dispersion with the use of dipoles, and a correlation between energy loss and position with the use of wedge absorbers. A detailed description of this lattice configuration and analysis is given, together with preliminary results.
Assessing Drying Shrinkage Induced Deterioration of Concrete Stored at Distinct Exposure Conditions
Creators: name: Zhu, Xiangyu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2024
Subjects: Drying shrinkage
Relative humidity
Microscopic techniques
Damage Rating Index (DRI)
Cracks in Cement Paste (CCP)
Interfacial Transition Zone (ITZ)

description: Drying shrinkage is a damage mechanism that may potentially lead to the deterioration of concrete infrastructures. As the moisture content of concrete decreases over time, it undergoes a process of drying shrinkage, which subsequently induces a volume reduction, mass loss, and microcracks to the material. Although many studies and approaches to evaluate drying shrinkage have provided significant insights on the mechanism developments, the use of advanced microscopic techniques holds the potential for a more detailed and comprehensive evaluation of the generation and propagation of induced cracks. The damage rating index (DRI), a microscopic damage assessment protocol, has been proven to be an effective method to appraise and comprehend crack generation and propagation induced by the internal swelling reaction (ISR) mechanism. However, this procedure has never been used to assess shrinkage. Therefore, this work aims to assess the influence of relative humidity and temperature on the drying shrinkage mechanism and to assess the efficiency of using DRI to evaluate the deterioration of drying shrinkage on concrete according to the length change of concrete specimens with distinct exposure conditions. Furthermore, the cracks in cement paste (CCP) induced by drying shrinkage are investigated for the association with pores and interfacial transition zone (ITZ) in concrete.
Organic solvent nanofiltration in the synthesis of DNA oligonucleotides and heterobifunctional polymers
Creators: name: Campos Vasconcelos, Renato
Publisher: name: Imperial College London
Year: 2010

description: DNA and RNA oligonucleotides are molecules of great interest due to their potential application as antisense and RNAi drugs. Currently, solid phase synthesis (SPS) is the method of choice for their synthesis due to its simplicity, automation, and simple intermediate purification. However, large scale synthesis is challenging due to its 2- phase reaction medium. This research investigates a novel method – Membrane Enhanced Oligonucleotide Synthesis (MEOS) – for the synthesis of DNA oligonucleotides. This novel process combines synthesis on a soluble polymeric support with the emergent separation technology Organic Solvent Nanofiltration (OSN). The synthesis of support-bound oligonucleotide dimers was first attempted using linear MeOPEG112 as the soluble support, and ceramic and cross-linked polyimide OSN membranes. The performance of OSN membranes was characterised prior to synthesis in order to selected membranes with appropriate performance properties. Poor process yields lead to the development of novel branched PEG supports. PEG silyl ethers, phosphate and carboxylic esters were prepared in a novel methodology using an OSN membrane for the separation of the branched PEG from excess PEG diol. The use of branched PEGs resulted in an increase of the MEOS process yields in the range of ~3 to 6 fold. Best results for the MEOS process were obtained in the synthesis of a fully unprotected dimer, dApdA, using a 3-arm PEG carboxylic ester with MW of ~ 9,000 g mol-1 [benzene-1,3,5-(CO2-PEG67)3]. The synthesis of DNA monomers using OSN was also investigated. This investigation also describes a novel synthetic method for the synthesis of heterobifunctional PEGs. PEGs of MW of ~ 2,000 g mol-1 were prepared and characterised with monophthalimide, monoamine, and monoazide functionalities. Overall, this research investigates the use of OSN in two different applications for organic synthesis, namely the synthesis of DNA oligonucleotides and derivatised (branched and linear) PEGs.
X-ray Spectroscopy of Bursts from SGR 1806-20 with RXTE
Creators: name: Strohmayer, Tod E.
name: Ibrahim, Alaa
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on new RXTE X-ray spectral analysis of bursts from SGR 1806-20, the most prolific SGR source known. Previous studies of bursts from this source revealed a remarkable lack of spectral variability both in single bursts as well as from burst to burst. We present here some of the first evidence for significant spectral evolution within SGR bursts. We find that optically thin thermal bremsstrahlung (OTTB) spectra including photoelectric absorption provide the best fits to most bursts, however, other models (power law, Band GRB) can also produce statistically acceptable fits. We confirm the existence of a rolloff in the photon number spectrum below 5 keV.
description: 5 pages, 5 figures, LaTeX AIP Proceedings article, to appear in the proceedings of the 4th BATSE Gamma-Ray burst workshop in Hunstville, AL
Investigation of Fracture in Polymeric Coatings
Creators: name: Tantideeravit, Soratos
Publisher: name: Imperial College London
Year: 2013

description: The objective of this study is to quantify the effect of low amplitude cyclic stresses, such as those induced by environmental condition fluctuations and transportation, on multilayer paint systems found in works of art. A model was developed to establish criteria for damage, which take into account viscoelastic fatigue, and to establish safe rates of change for environmental parameters. To establish the methodology, the investigation focused on modern paintings executed in mixed media. In particular, acrylic gesso grounds with superimposed alkyd paint layers on canvas were investigated, which have been found to be vulnerable to stresses and delamination. Data from uniaxial testing of free-standing paint films were used to determine the constitutive properties of the paint. The effects of temperature, strain rate and age on the tensile properties were investigated. Results from peel tests, performed to determine the energy release rate of the interface between the paint and gesso layers, are reported. The peel tests were modelled using Finite Element Analysis with cohesive zone elements at the interface in a commercial finite element software Abaqus. The value of the maximum traction in the traction-separation law was determined by comparing numerical and experimental peel loads and the cohesive energy was determined using an established analytical method. The cohesive zone properties determined from the peel tests, and the calibrated constitutive model for the alkyd paint, were used in a separate finite element model of a coating on a primed canvas substrate subjected to combined cyclic hygrothermal and static mechanical loadings typically experienced by fine art paintings; interface separation was controlled by an irreversible cohesive zone model that includes damage accumulation due to cyclic loading. Fatigue crack initiation times in years, and crack propagation rates, are predicted under various conditions including ordinary and extreme histories that paintings may experience in museum and conservation settings.
Modulation of purinergic signalling in macrophages and T cells by Trichinella spiralis secreted proteins
Creators: name: Eleftheriou, Emily
Publisher: name: Imperial College London
Year: 2011

description: Extracellular nucleotides are signalling molecules whose purinergic receptor-mediated effects are known to be key regulators of inflammatory and other immune responses, and they are considered archetypal activators of the innate immune system. It has been shown by our group that infective larvae of Trichinella spiralis secrete enzymes which catalyze the degradation of extracellular nucleotides, and thus potentially interfere with host cell purinergic receptor signalling. Murine bone marrow-derived macrophages (BMMΦ) of various activation states and CD4+ T cells were used to examine the effects of T. spiralis secreted proteins on immune cell purinergic signalling. This study showed, by PCR and pharmacological analyses, that these cell types possess functional purinergic receptors and the sub-types of receptors responsible for the signalling events were identified. It was shown that the ecto-nucleotidases, CD39 and CD73, were functionally expressed on BMMΦ and CD4+ T cells. The signalling events which were triggered following purinergic receptor stimulation were inhibited by T.spiralis secreted enzymes due to metabolism of nucleotides to adenosine. It was shown that the action of T.spiralis secreted proteins enhanced anti-inflammatory processes, such as IL-10 release and arginase I activity in BMMΦ, while NO, TNF-α and IL-6 release were inhibited. In CD4+ T cells, proliferation and cytokine release were all inhibited by adenosine generation. Pharmacological characterisation of adenosine-induced effects on these cells showed that they were predominantly due to A2R activation. In addition to the interference with purinergic signalling, T.spiralis secreted products were shown to have direct effects on BMMΦ and T cell effector functions and this was shown to be due to the glycan component of the secreted proteins. In BMMΦ, T.spiralis glycans appeared to activate C-type lectins, and in particular, the Macrophage Galactose Lectin (MGL). Thus the parasite, via its secreted proteins, appears to interfere with host purinergic signalling as well as having direct effects on immune cells by activation of C-type lectins.
Spectra of GRB 970228 from the Transient Gamma-Ray Spectrometer
Creators: name: Palmer, D. M.
name: Cline, T. L.
name: Gehrels, N.
name: Hurley, K.
name: Kurczynski, P.
name: Madden, N.
name: Pehl, R.
name: Ramaty, R.
name: Seifert, H.
name: Teegarden, B. J.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Visible afterglow counterparts have now been detected for two GRBs (970228 and 970508) but are absent, with $L_{opt}/L_γ$ ratios at least two orders of magnitude lower, for other GRBs, e.g., 970828. The causes of this variation are unknown. Any correspondence which could be discovered between the gamma-ray properties of a GRB and its $L_{opt}/L_γ$ would be useful, both in determining the GRB mechanisms, and in allocating resources for counterpart searches and studies. This paper presents the gamma-ray spectra of GRB 970228 as measured by the Transient Gamma-Ray Spectrometer and comments on characteristics of this GRB compared to others that do and do not have observable counterparts.
description: To appear in "Gamma-Ray Bursts", Proceedings of the 4th Huntsville Symposium, 1997, eds. C. Meegan, R. Preece, and T. Koshut, 5 pages, LaTeX (aipproc.sty incl.), 3 figs. (epsfig.sty)