cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A genome-wide scan for common alleles affecting risk for autism
Creators: name: Bacchelli, E.
name: Berney, T.
name: Brian, J.
name: Baird, G.
name: Brennan, S.
name: Bailey, A. J.
name: Anney, R.
name: Bolshakova, N.
name: Battaglia, A.
name: Chu, S. H.
name: Casey, J.
name: Bourgeron, T.
name: Magalhaes, T. R.
name: Bolte, S.
name: Carson, A. R.
name: Casallo, G.
name: Almeida, J.
name: Klei, L.
name: Conroy, J.
name: de Jonge, M.
name: Sykes, N.
name: Crossett, A.
name: Cochrane, L.
name: Abrahams, B. S.
name: Pinto, D.
name: Regan, R.
name: Correia, C.
name: Crawford, E. L.
name: Pagnamenta, A. T.
name: Bolton, P. F.
name: Dawson, G.
name: Corsello, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
A risk management system for healthcare facilities service operators
Creators: name: Gombera, Peter Pachipano
Publisher: name: University of Derby
Year: 2003
Subjects: NHS
Healthcare
practice guidelines

description: The 24-hour post-modern society in which the NHS delivers healthcare today in the UK as a business has resulted in purchasers and providers of non clinical/FM services continuing to face more and more service delivery and operational risks (Payne and Rees, 1999). These business risks are mainly caused by uncertainties in customer supply and demand service chain, limited support resources (human, capital, modern healthcare facilities and information technology) and the dynamic NHS service scape (environment). This has resulted in non clinical service decisions being reached in an ad-hoc manner and often with no effective business strategy. Furthermore, this approach has led to disastrous business planning and caring consequences, particularly in a highly politicised and consumer-sensitive environment like healthcare service provision (Wagstaff, 1997). These risks are also mainly attributed to the apparent lack of best practice guidelines that are available to assist FM service operators in identifying and managing non-clinical service operations effectively. In addition, there is evidence from NHS literature that clearly indicates the lack of best practice models for managing business risks associated with hotel, estates and site (non-clinical/FM) services delivery (Okoroh et al., 2000; DoH, 1999; CFM, 1993; Smith, 1997; Featherstone, 1999; HFN 17,1998). To date, no research has been carried out in the NHS using FM service operators' (domain experts) knowledge to develop an integrated risk management system for managing non-clinical services using modern business approaches. This thesis presents research findings from healthcare executives and FM experts on business risks faced by service operators (purchasers and providers) when managing non- clinical services effectively in the UK NHS. The research methodology used were, a detailed analysis of a best practice hospital case study, structured interviews with domain healthcare FM experts, pilot and major questionnaire surveys and Repertory Grid interviews. The research has established that in managing non clinical/FM services in the NHS, there are seven major common management-related risk classes identified as critical; customer care; financial and economic; commercial; legal; facility-transmitted; business transfer and corporate. Further research using second factor analysis established that these classical non-clinical risk factors could further be subdivided into forty-eight (48) constructs/sub-attributes highly rated by healthcare facilities executives. Using these risks factors and sub-attributes the research has developed a decision support system for risk management that can be used by FM operators to manage business risks in NHS trust hospitals.
Investigating Microbial Quorum Sensing Potential for Enhanced Production of Biodegradable Polymers
Creators: name: Aziz, Zain
Publisher: name: University of Westminster
Year: 2021

description: Polyhydroxyalkanoates (PHA) are a type of biopolymer that can be biosynthesised and accumulated by several specialised bacterial species. Their favourable mechanical properties coupled with their ability to naturally biodegrade within the environment make PHAs a potential candidate to replace tradition plastics, which cause harm to our environment, our wildlife and ourselves. One of the main drawbacks associated with PHAs, is the difficulty of producing them in large quantities, which hinders their potential usage. However, the manipulation of quorum sensing circuits has yet to be explored in the context of increasing the amount of PHA produced by bacterial species. Quorum sensing is a process of cell-to-cell communication, that allows for bacteria to share information about cell densities and coordinate gene expression, such as altering the production of secondary metabolites like PHAs. During this study two Gram-negative bacterial species (Cupriavidus necator H16 and Pseudomonas putida KT2440) were grown in specific production media and supplemented with three different exogenous quorum molecules sensing (C4-HSL, C6-HSL and 3-oxo-C12-HSL), to study if there was a change in the amount of PHA produced. It was observed that C. necator H16 increased production of PHAs, specifically small chain length PHA (SCL PHA) poly(3-hydroxybutyrate) (P(3HB)), by 13.03% and 17.85% when grown in shake flasks and bioreactors, when supplemented with the quorum sensing molecule 3-oxo-C12-HSL. Whilst PHA production increased in culture of P. putida KT2440, when supplemented with C4-HSL. PHA production of the medium chain length polymer (MCL PHA) of poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate) (P(3HO-co-3HD-co-3HDD)) increased by 7.24% and 10.89% when grown in shake flasks and bioreactors, respectively. To understand as to why there was a change in production of PHAs produced by the two species of bacteria, qPCR was used to measure the expression of two key Pha genes (PhaC1 and PhaZ) when exposed to exogenous quorum sensing molecules in bioreactors. C. necator H16 displayed an increase in regulation of the PhaC1 gene, within 24 hours of fermentation by 2.53-fold when supplemented with 3-oxo-C12-HSL. Alternatively, PhaZ displayed an increase in transcription at the same time point, but by 1.48-fold. P. putida KT2440 cultures displayed a significant increase in regulation of PhaC1 at 48 hours of fermentation when supplemented with both C4-HSL and 3-oxo-C12-HSL. Although an increase of PhaZ was also observed, it was less than PhaC1.
Reconstruction, Thermodynamics and Stability of $Λ$CDM Model in $f(T,\mathcal{T})$ Gravity
Creators: name: Junior, Ednaldo L. B.
name: Rodrigues, Manuel E.
name: Salako, Ines G.
name: Houndjo, Mahouton J. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We reconstruct the $Λ$CDM model for $f(T,\mathcal{T})$ Theory, where $T$ is the torsion scalar and $\mathcal{T}$ the trace of the energy-momentum tensor. The result shows that the action of $Λ$CDM is a combination of a linear term, a constant ($-2Λ$) and a non-linear term given by the product $\sqrt{-T}F_g\left[(T^{1/3}/16πG)\left(16πG\mathcal{T}+T+8Λ\right)\right]$, with $F_g$ being a generic function. We show that to maintain conservation of energy-momentum tensor should impose that $F_g[y]$ must be linear on the trace $\mathcal{T}$. This reconstruction decays in the $f(T)$ Theory for $F_g\equiv Q$, with $Q$ a constant. Our reconstruction describes the cosmological eras to the present time. The model present stability within the geometric and matter perturbations for the choice $F_g=y$, where $y=(T^{1/3}/16πG)\left(16πG\mathcal{T}+T+8Λ\right)$, except for geometric part to de Sitter model. We impose the first and second laws of thermodynamics to the $Λ$CDM and find the condition where they are satisfied, that is, $T_A,G_{eff}>0$, however where this is not possible for cases where we choose, leading to a breakdown of positive entropy and Misner-Sharp energy.
description: 15 pages, 3 figures, revtex4 format. arXiv admin note: text overlap with arXiv:1506.08695 by other authors
Allele-specific and heritable chromatin signatures in humans
Creators: name: Furey, T. S.
name: Iyer, V. R.
name: Crawford, G. E.
name: Birney, E.
name: Lieb, J. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Next-generation sequencing-based assays to detect gene regulatory elements are enabling the analysis of individual-to-individual and allele-specific variation of chromatin status and transcription factor binding in humans. Recently, a number of studies have explored this area, using lymphoblastoid cell lines. Around 10% of chromatin sites show either individual-level differences or allele-specific behavior. Future studies are likely to be limited by cell line accessibility, meaning that white-bloodcell-based studies are likely to continue to be the main source of samples. A detailed understanding of the relationship between normal genetic variation and chromatin variation can shed light on how polymorphisms in non-coding regions in the human genome might underlie phenotypic variation and disease.
Context Information for Fast Cell Discovery in mm-wave 5G Networks
Creators: name: Capone, Antonio
name: Filippini, Ilario
name: Sciancalepore, Vincenzo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The exploitation of the mm-wave bands is one of the most promising solutions for 5G mobile radio networks. However, the use of mm-wave technologies in cellular networks is not straightforward due to mm-wave harsh propagation conditions that limit access availability. In order to overcome this obstacle, hybrid network architectures are being considered where mm-wave small cells can exploit an overlay coverage layer based on legacy technology. The additional mm-wave layer can also take advantage of a functional split between control and user plane, that allows to delegate most of the signaling functions to legacy base stations and to gather context information from users for resource optimization. However, mm-wave technology requires high gain antenna systems to compensate for high path loss and limited power, e.g., through the use of multiple antennas for high directivity. Directional transmissions must be also used for the cell discovery and synchronization process, and this can lead to a non-negligible delay due to the need to scan the cell area with multiple transmissions at different directions. In this paper, we propose to exploit the context information related to user position, provided by the separated control plane, to improve the cell discovery procedure and minimize delay. We investigate the fundamental trade-offs of the cell discovery process with directional antennas and the effects of the context information accuracy on its performance. Numerical results are provided to validate our observations.
description: 6 pages, 8 figures, in Proceedings of European Wireless 2015
Mapping the Politics of Vision: searching for a transformative gaze
Creators: name: Hugonnier, Marine
Publisher: name: University of Westminster
Year: 2021

description: Through this commentary, my intention is to create a coherent rationale to account for my film practice, which is based on, and is the result of, research. This reflective process will draw out the aesthetic and political approaches that I have forged over the last ten years, so as to reveal their singularity. To do so, I revisit and contextualize four of my film works, which were produced between 2014 and 2018: Apicula Enigma (2014), Desire is Not Much, But Nonetheless (2015), May 13th,1968 (2011) and Cinétracts (2012 – 2018). Their subjects are, respectively, the non-human gaze, the gendered gaze, and the dominant gaze. I demonstrate how these works are an attempt to deconstruct the inherent complicity between the gaze and political ideology and, as such, I outline the profile of an artistic practice that understands filmmaking as being a transformative and seditious act. To reveal this, I elaborate on the position of the author and on the distance between the observer and the observed, which is understood as being a critical space. This leads this commentary to examine how these four films are intended to form a social critique in which the question of gender is at its core. Feminism, gender fluidity, and the anti-colonial and post-human perspectives will be brought forward in order to expose the underlying political outreach of these four works. This commentary also investigates the relationship between the materiality of film and its illusion – the meaning of the tension produced. The production of film, as well as its reception and exhibition, form a critical space on which this commentary will focus in order to expose the particularity of the processes that were involved in the making of these films. I will analyse how the politics of vision is the uniting thread of my practice, the goal of which is to deconstruct the cultural frame that informs the gaze in the search for an unalienated and transformative one. My aim, in this commentary, is to reveal the potential of my work, and to understand my position as a woman and my role as an artist, so as to affirm the emancipatory value of my practice and to take it forward.
Additional file 1 of Socioeconomic status of patients in a Swedish national self-management program for osteoarthritis compared with the general population—a descriptive observational study
Creators: name: Gustafsson, Kristin
name: Kvist, Joanna
name: Eriksson, Marit
name: Dahlberg, Leif
name: Rolfson, Ola
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Description of the nine indicators of socioeconomic status (SES) used in the study.
Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK
Creators: name: Prokunina-Olsson, Ludmila
name: Mohlke, Karen L.
name: Xiao, Rui
name: Fogarty, Marie P.
name: Scott, Laura J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Genome-wide association studies (GWAS) have identified numerous loci associated with various complex traits for which the underlying susceptibility gene(s) remain unknown. In a GWAS for high-density lipoprotein-cholesterol (HDL-C) level, one strongly associated locus contains at least two biologically compelling candidates, methylmalonic aciduria cblB type (MMAB) and mevalonate kinase (MVK). To detect evidence of cis-acting regulation at this locus, we measured relative allelic expression of transcribed SNPs in five genes using human hepatocyte samples heterozygous for the transcribed SNP. If an HDL-C-associated SNP allele differentially regulates mRNA level in cis, samples heterozygous both for a transcribed SNP and an HDL-C-associated SNP should display allelic expression imbalance (AEI) of the transcribed SNP. We designed statistical tests to detect AEI in a comprehensive set of linkage disequilibrium (LD) scenarios between the transcribed SNP and an HDL-C-associated SNP (rs7298565) in phase unknown samples. We observed significant AEI of 22% in MMAB (P = 1.4 × 10−13, transcribed SNP rs11067231), and the allele associated with lower HDL-C level was associated with greater MMAB transcript level. The same rs7298565 allele was also associated with higher MMAB mRNA level (P = 0.0081) and higher MMAB protein level (P = 0.0020). In contrast, MVK, UBE3B, KCTD10 and ACACB did not show significant AEI (P ≥ 0.05). These data suggest MMAB is the most likely gene influencing HDL-C levels at this locus and demonstrate that measuring AEI at loci containing more than one candidate gene can prioritize genes for functional studies.
On factorization of multiparticle pentagons
Creators: name: Belitsky, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We address the near-collinear expansion of multiparticle NMHV amplitudes, namely, the heptagon and octagons in the dual language of null polygonal super Wilson loops. In particular, we verify multiparticle factorization of charged pentagon transitions in terms of pentagons for single flux-tube excitations within the framework of refined operator product expansion. We find a perfect agreement with available tree and one-loop data.
description: 30 pages, 3 figures, 1 ancillary file; updated conventions
Genome-wide association analysis identifies multiple loci related to resting heart rate
Creators: name: Sotoodehnia, N.
name: Eijgelsheim, M.
name: Muller, M.
name: Newton-Cheh, C.
name: Navarro, P.
name: Spector, T. D.
name: Rivadeneira, F.
name: Hottenga, J. J.
name: de Bakker, P. I. W.
name: Perz, S.
name: Hwang, S.-J.
name: Fuchsberger, C.
name: Nolte, I. M.
name: de Geus, E. J. C.
name: Noseworthy, P. A.
name: Ruckert, I.-M.
name: Morrison, A. C.
name: Sanna, S.
name: Isaacs, A.
name: Arking, D. E.
name: Estrada, K.
name: Bis, J. C.
name: Tarasov, K. V.
name: Alonso, A.
name: Aulchenko, Y. S.
name: Wild, S. H.
name: Smith, A. V.
name: Rice, K. M.
name: Dorr, M.
name: Kors, J. A.
name: Launer, L. J.
name: Homuth, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38 991 subjects of European ancestry, estimating the association between age-, sex- and body mass-adjusted RR interval (inverse heart rate) and ∼2.5 million markers. Results with P < 5 × 10−8 were considered genome-wide significant. We constructed regression models with multiple markers to assess whether results at less stringent thresholds were likely to be truly associated with RR interval. We identified six novel associations with resting heart rate at six loci: 6q22 near GJA1; 14q12 near MYH7; 12p12 near SOX5, c12orf67, BCAT1, LRMP and CASC1; 6q22 near SLC35F1, PLN and c6orf204; 7q22 near SLC12A9 and UfSp1; and 11q12 near FADS1. Associations at 6q22 400 kb away from GJA1, at 14q12 MYH6 and at 1q32 near CD34 identified in previously published GWAS were confirmed. In aggregate, these variants explain ∼0.7% of RR interval variance. A multivariant regression model including 20 variants with P < 10−5 increased the explained variance to 1.6%, suggesting that some loci falling short of genome-wide significance are likely truly associated. Future research is warranted to elucidate underlying mechanisms that may impact clinical care.
CLT for Largest Eigenvalues and Unit Root Tests for High-Dimensional Nonstationary Time Series
Creators: name: Zhang, Bo
name: Pan, Guangming
name: Gao, Jiti
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper first considers some testing issues for a vector of high-dimensional time series before it establishes a joint distribution for the largest eigenvalues of the
The New Robotic Telescope's Polarimetry Plan
Creators: name: Jermak, Helen
Publisher: name: Zenodo
Year: 2022
Subjects: robotic, telescope, polarimetry, time domain, rapid response

description: The New Robotic Telescope (NRT) is a 4-metre class, fully autonomous, robotic optical facility due to join the Liverpool Telescope on Roque de los Muchachos on the Canary Island of La Palma, Spain in 2026. With a time-to-target requirement of 30 seconds, the NRT will be one of the earliest-responding ground-based facilities to provide optical spectroscopic, polarimetric and photometric observations of explosive and energetic targets identified by survey and satellite telescopes. One of the main science foci of the NRT is the exploitation of facility’s polarimetric capabilities; particularly in the context of synchrotron-emitting objects such as gamma-ray bursts and blazars, along with dusty environments. I will present the Liverpool Telescope’s polarimetric successes over the past 18 years, and show how these shape the NRT’s science and instrumentation requirements. I will then discuss the NRT’s capabilities in the context of polarimetric science over the coming years and invite the community to contribute and comment on key NRT scheduling and instrumentation requirements.
A Spectral Characterization of $\mathcal{AN}$ Operators
Creators: name: Pandey, Satish K.
name: Paulsen, Vern I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: We establish a spectral characterization theorem for the operators on complex Hilbert spaces of arbitrary dimensions that attain their norm on every closed subspace. The class of these operators is not closed under addition. Nevertheless, we prove that the intersection of these operators with the positive operators forms a proper cone in the real Banach space of hermitian operators.
description: 21 pages
A Novel Implementation of QuickHull Algorithm on the GPU
Creators: name: Zhang, Jiayin
name: Mei, Gang
name: Xu, Nengxiong
name: Zhao, Kunyang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Geometry (cs.CG)
subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: We present a novel GPU-accelerated implementation of the QuickHull algorihtm for calculating convex hulls of planar point sets. We also describe a practical solution to demonstrate how to efficiently implement a typical Divide-and-Conquer algorithm on the GPU. We highly utilize the parallel primitives provided by the library Thrust such as the parallel segmented scan for better efficiency and simplicity. To evaluate the performance of our implementation, we carry out four groups of experimental tests using two groups of point sets in two modes on the GPU K20c. Experimental results indicate that: our implementation can achieve the speedups of up to 10.98x over the state-of-art CPU-based convex hull implementation Qhull [16]. In addition, our implementation can find the convex hull of 20M points in about 0.2 seconds.
description: 10 pages, 5 figures
Calibrating an ice sheet model using high-dimensional binary spatial data
Creators: name: Chang, Won
name: Haran, Murali
name: Applegate, Patrick
name: Pollard, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Rapid retreat of ice in the Amundsen Sea sector of West Antarctica may cause drastic sea level rise, posing significant risks to populations in low-lying coastal regions. Calibration of computer models representing the behavior of the West Antarctic Ice Sheet is key for informative projections of future sea level rise. However, both the relevant observations and the model output are high-dimensional binary spatial data; existing computer model calibration methods are unable to handle such data. Here we present a novel calibration method for computer models whose output is in the form of binary spatial data. To mitigate the computational and inferential challenges posed by our approach, we apply a generalized principal component based dimension reduction method. To demonstrate the utility of our method, we calibrate the PSU3D-ICE model by comparing the output from a 499-member perturbed-parameter ensemble with observations from the Amundsen Sea sector of the ice sheet. Our methods help rigorously characterize the parameter uncertainty even in the presence of systematic data-model discrepancies and dependence in the errors. Our method also helps inform environmental risk analyses by contributing to improved projections of sea level rise from the ice sheets.
Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ
Creators: name: Mohlke, Karen L.
name: Curocichin, Ghenadie
name: Lange, Leslie A.
name: Adair, Linda S.
name: McDade, Thomas W.
name: Croteau-Chonka, Damien C.
name: Li, Yun
name: Wu, Ying
name: Kuzawa, Christopher W.
name: Qin, Li
name: Borja, Judith B.
name: Lange, Ethan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. We conducted a genome-wide association study to investigate the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Our strongest signal for adiponectin mapped to the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), which encodes a receptor for high-molecular-weight forms of adiponectin. Strong association was also detected near the ADIPOQ gene (rs864265, P = 3.8 × 10−9) and at a novel signal 100 kb upstream near KNG1 (rs11924390, P = 7.6 × 10−7). All three signals were also observed in 1774 young adult CLHNS offspring and in combined analysis including all 3550 mothers and offspring samples (all P ≤ 1.6 × 10−9). An uncommon haplotype of rs11924390 and rs864265 (haplotype frequency = 0.050) was strongly associated with lower adiponectin compared with the most common C–G haplotype in both CLHNS mothers (P = 1.8 × 10−25) and offspring (P = 8.7 × 10−32). Comprehensive imputation of 2653 SNPs in a 2 Mb region using as reference combined CHB, JPT and CEU haplotypes from the 1000 Genomes Project revealed no variants that perfectly tagged this haplotype. Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1–ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos.
CEstimation of Structural Breaks in Large Panels with Cross-Sectional Dependence
Creators: name: Gao, Jiti
name: Pan, Guangming
name: Yang, Yanrong
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper considers modelling and detecting structure breaks associated with cross-sectional dependence for large dimensional panel data models, which are popular
การก่อการร้ายในเมืองร่วมสมัย: การโจมตีและการป้องกัน
Creators: name: สุรชาติ บำรุงสุข
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Urban Terrorism
Urban Threat
Pattern of Violence
Urban Security

description: Journal of Politics and Governance, 10, 3, 1-18
Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults
Creators: name: Levy, Shawn
name: Marvelle, Amanda F.
name: McDade, Thomas W.
name: Wang, Yunfei
name: Croteau-Chonka, Damien C.
name: Borja, Judith B.
name: Mohlke, Karen L.
name: Lange, Leslie A.
name: Adair, Linda S.
name: Gaulton, Kyle J.
name: Lange, Ethan M.
name: Li, Yun
name: Kuzawa, Christopher W.
name: Qin, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Plasma homocysteine (Hcy) level is associated with cardiovascular disease and may play an etiologic role in vascular damage, a precursor for atherosclerosis. We performed a genome-wide association study for Hcy in 1786 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). The most strongly associated single-nucleotide polymorphism (SNP) (rs7422339, P = 4.7 × 10−13) encodes Thr1405Asn in the gene CPS1 and explained 3.0% of variation in the Hcy level. The widely studied MTHFR C677T SNP (rs1801133) was also highly significant (P = 8.7 × 10−10) and explained 1.6% of the trait variation. We also genotyped these two SNPs in 1679 CLHNS young adult offspring. The MTHFR C677T SNP was strongly associated with Hcy (P = 1.9 × 10−26) and explained ∼5.1% of the variation in the offspring. In contrast, the CPS1 variant was significant only in females (P = 0.11 in all; P = 0.0087 in females). Combined analysis of all samples confirmed that the MTHFR variant was more strongly associated with Hcy in the offspring (interaction P = 1.2 × 10−5). Furthermore, although there was evidence for a positive synergistic effect between the CPS1 and MTHFR SNPs in the offspring (interaction P = 0.0046), there was no significant evidence for an interaction in the mothers (P = 0.55). These data confirm a recent finding that CPS1 is a locus influencing Hcy levels in women and suggest that genetic effects on Hcy may differ across developmental stages.
A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium
Creators: name: Kivimaki, Mika
name: Folsom, Aaron R.
name: Taylor, Kira C.
name: North, Kari E.
name: Lange, Leslie A.
name: Tang, Weihong
name: Reiner, Alexander P.
name: Delaney, Joseph A.
name: Keating, Brendan J.
name: Green, David
name: Lange, Ethan
name: Tracy, Russell P.
name: Kumari, Meena
name: Zabaneh, Delilah
name: Hingorani, Aroon
name: Smith, Nicholas L.
name: Humphries, Steve E.
name: O'Donnell, Christopher J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Polymorphisms in several distinct genomic regions, including the F7 gene, were recently associated with factor VII (FVII) levels in European Americans (EAs). The genetic determinants of FVII in African Americans (AAs) are unknown. We used a 50 000 single nucleotide polymorphism (SNP) gene-centric array having dense coverage of over 2 000 candidate genes for cardiovascular disease (CVD) pathways in a community-based sample of 16 324 EA and 3898 AA participants from the Candidate Gene Association Resource (CARe) consortium. Our aim was the discovery of new genomic loci and more detailed characterization of existing loci associated with FVII levels. In EAs, we identified three new loci associated with FVII, of which APOA5 on chromosome 11q23 and HNF4A on chromosome 20q12–13 were replicated in a sample of 4289 participants from the Whitehall II study. We confirmed four previously reported FVII-associated loci (GCKR, MS4A6A, F7 and PROCR) in CARe EA samples. In AAs, the F7 and PROCR regions were significantly associated with FVII. Several of the FVII-associated regions are known to be associated with lipids and other cardiovascular-related traits. At the F7 locus, there was evidence of at least five independently associated SNPs in EAs and three independent signals in AAs. Though the variance in FVII explained by the existing loci is substantial (20% in EA and 10% in AA), larger sample sizes and investigation of lower frequency variants may be required to identify additional FVII-associated loci in EAs and AAs and further clarify the relationship between FVII and other CVD risk factors.
ธุรกิจของกองทัพแห่งชาติพม่าในช่วงระบอบนายพลเนวิน (ค.ศ. 1962-1988)
Creators: name: เอนกชัย เรืองรัตนากร
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Military Business
Tatmadaw
Myanmar

description: Journal of Politics and Governance, 10, 3, 19-39
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium
Creators: name: Keating, Brendan J.
name: Dries, Daniel
name: Liu, Kiang
name: Zhu, Xiaofeng
name: Chiang, Charleston W.K.
name: Adeyemo, Adebowale
name: Vasan, Ramachandran S.
name: Townsend, Raymond R.
name: Newton-Cheh, Christopher
name: Tayo, Bamidele
name: Ganesh, Santhi K.
name: Hirschhorn, Joel N.
name: Li, Yali
name: Kutlar, Abdullah
name: Dreisbach, Albert
name: Palmas, Walter
name: Fox, Ervin
name: Rotimi, Charles
name: Wyatt, Sharon
name: Mosley, Thomas
name: Morrison, Alanna
name: Sun, Yun V.
name: Taylor, Herman
name: Kardia, Sharon
name: Curb, David
name: Young, J.H.
name: Glessner, Joseph
name: Fabsitz, Richard
name: Kang, Sunjung
name: Franceschini, Nora
name: Musani, Solomon
name: Polak, Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Admixture mapping based on recently admixed populations is a powerful method to detect disease variants with substantial allele frequency differences in ancestral populations. We performed admixture mapping analysis for systolic blood pressure (SBP) and diastolic blood pressure (DBP), followed by trait-marker association analysis, in 6303 unrelated African-American participants of the Candidate Gene Association Resource (CARe) consortium. We identified five genomic regions (P< 0.001) harboring genetic variants contributing to inter-individual BP variation. In follow-up association analyses, correcting for all tests performed in this study, three loci were significantly associated with SBP and one significantly associated with DBP (P< 10−5). Further analyses suggested that six independent single-nucleotide polymorphisms (SNPs) contributed to the phenotypic variation observed in the admixture mapping analysis. These six SNPs were examined for replication in multiple, large, independent studies of African-Americans [Women's Health Initiative (WHI), Maywood, Genetic Epidemiology Network of Arteriopathy (GENOA) and Howard University Family Study (HUFS)] as well as one native African sample (Nigerian study), with a total replication sample size of 11 882. Meta-analysis of the replication set identified a novel variant (rs7726475) on chromosome 5 between the SUB1 and NPR3 genes, as being associated with SBP and DBP (P< 0.0015 for both); in meta-analyses combining the CARe samples with the replication data, we observed P-values of 4.45 × 10−7 for SBP and 7.52 × 10−7 for DBP for rs7726475 that were significant after accounting for all the tests performed. Our study highlights that admixture mapping analysis can help identify genetic variants missed by genome-wide association studies because of drastically reduced number of tests in the whole genome.
MOESM1 of The refugee post-migration stress scale (RPMS) – development and validation among refugees from Syria recently resettled in Sweden
Creators: name: Malm, Andreas
name: Tinghög, Petter
name: Narusyte, Jurgita
name: Saboonchi, Fredrik
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Items, factors, and corresponding factorial loadings for the 7-factorial solution of post-migration stress in the exploratory factor analysis (EFA).
ชายแดนไทย-มาเลเซีย: เครือข่ายความสัมพันธ์ทางการค้าของผู้ค้ามลายูรายย่อย
Creators: name: มูฮำหมัดราพีร์ มะเก็ง
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Melayuness
Network to Trading Relationship
Retailers and Thailand - Malaysia Borders

description: Journal of Politics and Governance, 10, 3, 40-62
Impacts of different SNLS3 light-curve fitters on cosmological consequences of interacting dark energy models
Creators: name: Wang, Shuang
name: Hu, Yazhou
name: Li, Miao
name: Li, Nan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We explore the cosmological consequences of interacting dark energy (IDE) models using the SNLS3 supernova samples. In particular, we focus on the impacts of different SNLS3 light-curve fitters (LCF) (corresponding to "SALT2", "SiFTO", and "Combined" sample). Firstly, making use of the three SNLS3 data sets, as well as the Planck distance priors data and the galaxy clustering data, we constrain the parameter spaces of three IDE models. Then, we study the cosmic evolutions of Hubble parameter $H(z)$, deceleration diagram $q(z)$, statefinder hierarchy $S^{(1)}_3(z)$ and $S^{(1)}_4(z)$, and check whether or not these dark energy diagnosis can distinguish the differences among the results of different SNLS3 LCF. At last, we perform high redshift cosmic age test using three old high redshift objects (OHRO), and explore the fate of the Universe. We find that, the impacts of different SNLS3 LCF are rather small, and can not be distinguished by using $H(z)$, $q(z)$, $S^{(1)}_3(z)$, $S^{(1)}_4(z)$, and the age data of OHRO. In addition, we infer, from the current observations, how far we are from a cosmic doomsday in the worst case, and find that the "Combined" sample always gives the largest 2$σ$ lower limit of the time interval between "big rip" and today, while the results given by the "SALT2" and the "SiFTO" sample are close to each other. These conclusions are insensitive to a specific form of dark sector interaction. Our method can be used to distinguish the differences among various cosmological observations.
description: 12 pages, 7 figures, 2 tables, accepted for publication in Astronomy and Astrophysics
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
Creators: name: Ozcelik, Hilmi
name: Thomassen, Mads
name: Caligo, Maria A.
name: McGuffog, Lesley
name: Varesco, Liliana
name: Zaffaroni, Daniela
name: Dolcetti, Riccardo
name: Kruse, Torben A.
name: Peterlongo, Paolo
name: Birk Jensen, Uffe
name: Kartsonaki, Christiana
name: Laura Putignano, Anna
name: Antoniou, Antonis C
name: Soucy, Penny
name: Giannini, Giuseppe
name: Greene, Mark H.
name: Andrulis, Irene L.
name: Radice, Paolo
name: Mai, Phuong L.
name: Cattaneo, Elisa
name: Pasini, Barbara
name: Lee, Andrew
name: Manoukian, Siranoush
name: Glendon, Gord
name: Sinilnikova, Olga M.
name: Crüger, Dorthe G.
name: Peissel, Bernard
name: Laitman, Yael
name: Healey, Sue
name: Pensotti, Valeria
name: Gerdes, Anne-Marie
name: Barile, Monica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r2 = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11–1.23, P-trend = 4.5 × 10−9 for rs2046210; HR = 1.28, 95% CI: 1.18–1.40, P-trend = 1.3 × 10−8 for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01–1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02–1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92–1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
Copy number gain at Xp22.31 includes complex duplication rearrangements and recurrent triplications
Creators: name: Wiszniewska, Joanna
name: Eng, Patricia A.
name: Cooper, M. Lance
name: Berg, Jonathan S.
name: Shinawi, Marwan
name: Bi, Weimin
name: Simmons, Alexandra D.
name: Carvalho, Claudia M. B.
name: Patel, Ankita
name: Erez, Ayelet
name: Stankiewicz, Pawel
name: Liu, Pengfei
name: Sreenath Nagamani, Sandesh C.
name: Fang, Ping
name: Roeder, Elizabeth R.
name: Bodensteiner, John B.
name: Delgado, Mauricio R.
name: Belmont, John W.
name: Lupski, James R.
name: Cheung, Sau Wai
name: Sutton, V. Reid
name: Prakash, Siddharth K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Genomic instability is a feature of the human Xp22.31 region wherein deletions are associated with X-linked ichthyosis, mental retardation and attention deficit hyperactivity disorder. A putative homologous recombination hotspot motif is enriched in low copy repeats that mediate recurrent deletion at this locus. To date, few efforts have focused on copy number gain at Xp22.31. However, clinical testing revealed a high incidence of duplication of Xp22.31 in subjects ascertained and referred with neurobehavioral phenotypes. We systematically studied 61 unrelated subjects with rearrangements revealing gain in copy number, using multiple molecular assays. We detected not only the anticipated recurrent and simple nonrecurrent duplications, but also unexpectedly identified recurrent triplications and other complex rearrangements. Breakpoint analyses enabled us to surmise the mechanisms for many of these rearrangements. The clinical significance of the recurrent duplications and triplications were assessed using different approaches. We cannot find any evidence to support pathogenicity of the Xp22.31 duplication. However, our data suggest that the Xp22.31 duplication may serve as a risk factor for abnormal phenotypes. Our findings highlight the need for more robust Xp22.31 triplication detection in that such further gain may be more penetrant than the duplications. Our findings reveal the distribution of different mechanisms for genomic duplication rearrangements at a given locus, and provide insights into aspects of strand exchange events between paralogous sequences in the human genome.
Regulatory inhibition of biological tissue mineralization by calcium phosphate through post-nucleation shielding by Fetuin-A
Creators: name: Chang, Joshua C.
name: Miura, Robert M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Analysis of PDEs (math.AP)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: FOS: Biological sciences

description: In vertebrates, insufficient availability of calcium and phosphate ions in extracellular fluids leads to loss of bone density and neuronal hyper-excitability. To counteract this problem, calcium ions are present at high concentrations throughout body fluids -- at concentrations exceeding the saturation point. This condition leads to the opposite situation where unwanted mineral sedimentation may occur. Remarkably, ectopic or out-of-place sedimentation into soft tissues is rare, in spite of the thermodynamic driving factors. This fortunate fact is due to the presence of auto-regulatory proteins that are found in abundance in bodily fluids. Yet, many important inflammatory disorders such as atherosclerosis and osteoarthritis are associated with this undesired calcification. Hence, it is important to gain an understanding of the regulatory process and the conditions under which it can go awry. In this manuscript, we adapt mean-field classical nucleation theory to the case of surface-shielding in order to study the regulation of sedimentation of calcium phosphate salts in biological tissues through the mechanism of post-nuclear shielding of nascent mineral particles by binding proteins. We develop a mathematical description of this phenomenon using a countable system of hyperbolic partial differential equations. A critical concentration of regulatory protein is identified as a function of the physical parameters that describe the system.
description: Reverted to previous edition. This is the accepted manuscript
การพัฒนากลไกการจัดการแรงงานเพื่อการขับเคลื่อนนโยบายด้านแรงงานในเขตเศรษฐกิจพิเศษ จังหวัดมุกดาหาร
Creators: name: วชิรวัตติ์ อาริยะสิริโชติ
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Labour Management Mechanism
Labour Policy
Special Economic Zone

description: Journal of Politics and Governance, 10, 3, 63-87