Novel genetic loci associated with hippocampal volume
Creators: name: Hansell, Narelle K.
name: MacAre, Christine
name: Pandolfo, Massimo
name: Van 'T Ent, Dennis
name: Wassink, Thomas H.
name: Hibar, Derrek P.
name: Vardarajan, Badri N.
name: Calhoun, Vince D.
name: Wolfers, Thomas
name: Alhusaini, Saud
name: Gottesman, Rebecca F.
name: Troncoso, Juan
name: Sprooten, Emma
name: Cichon, Sven
name: Pausova, Zdenka
name: Hottenga, Jouke-Jan
name: Weale, Michael E.
name: Yanek, Lisa R.
name: Van Erp, Theo G. M.
name: Morris, Derek W.
name: Arepalli, Sampath
name: Rose, Emma J.
name: Jack, Clifford R.
name: Milaneschi, Yuri
name: Davies, Gareth E.
name: Sachdev, Perminder S.
name: Smoller, Jordan W.
name: Sämann, Philipp G.
name: Enzinger, Christian
name: Jenkinson, Mark
name: Satizabal, Claudia L.
name: Kasperaviciute, Dalia
name: Chouraki, Vincent
name: Blangero, John
name: Rommelse, Nanda
name: Gutman, Boris A.
name: Liu, Xinmin
name: Bohlken, Marc M.
name: Athanasiu, Lavinia
name: McMahon, Katie L.
name: Mosley, Thomas H.
name: Van Haren, Neeltje E. M.
name: Almasy, Laura
name: Gruber, Oliver
name: Brunner, Han G.
name: Schumann, Gunter
name: Le Hellard, Stephanie
name: De Jager, Philip L.
name: Cannon, Dara M.
name: Mattheisen, Manuel
name: Hoogman, Martine
name: Deary, Ian J.
name: Crivello, Fabrice
name: Cuellar-Partida, Gabriel
name: Kahn, René S.
name: Richards, Jennifer S.
name: Veltman, Dick J.
name: Jørgensen, Kjetil N.
name: Pirpamer, Lukas
name: Mühleisen, Thomas W.
name: Carmichael, Owen
name: Smith, Colin
name: Guadalupe, Tulio
name: Dillman, Allissa
name: Schmidt, Helena
name: Smith, Albert V.
name: Axelsson, Tomas
name: Völzke, Henry
name: Penninx, Brenda W.J.H.
name: Cahn, Wiepke
name: Wright, Margaret J.
name: Hernández, Maria C. Valdés
name: Johnson, Robert
name: Hofman, Albert
name: Guelfi, Sebastian
name: Hoehn, David
name: Bennett, David A.
name: Fox, Peter T.
name: Foroud, Tatiana M.
name: Luciano, Michelle
name: Sisodiya, Sanjay M.
name: Tsolaki, Magda
name: Hoffmann, Wolfgang
name: Beecham, Ashley H.
name: McDonald, Colm
name: Hegenscheid, Katrin
name: Desrivières, Sylvane
name: Gibbs, J. Raphael
name: Becker, James T.
name: Walton, Esther
name: Klein, Marieke
name: Kraemer, Bernd
name: Zijdenbos, Alex
name: Ching, Christopher R. K.
name: Fernández, Guillén
name: Schofield, Peter R.
name: McMahon, Francis J.
name: Knopman, David S.
name: Woldehawariat, Girma
name: Medland, Sarah E.
name: Holsboer, Florian
name: Reppermund, Simone
name: Wittfeld, Katharina
name: Boks, Marco P.
name: Bralten, Janita
name: Singleton, Andrew
name: Longstreth, 
name: Shin, Jean
name: Brodaty, Henry
name: Griswold, Michael E.
name: Fleischman, Debra A.
name: Adams, Hieab H.H.
name: Andersson, Micael
name: Zwiers, Marcel P.
name: Toga, Arthur W.
name: Soininen, Hilkka
name: Shen, Li
name: Kloszewska, Iwona
name: Hosten, Norbert
name: Lemaître, Hervé
name: Bulayeva, Kazima B.
name: Van Der Meer, Dennis
name: Lee, Phil H.
name: Whelan, Christopher D.
name: Van Tol, Marie-Jose
name: McIntosh, Andrew M.
name: Westlye, Lars T.
name: Huentelman, Matthew
name: Van Duijn, Cornelia M.
name: Vaidya, Dhananjay
name: Lopez, Lorna M.
name: Zonderman, Alan B.
name: Martinez, Oliver
name: Romanczuk-Seiferth, Nina
name: Homuth, Georg
name: Van Der Grond, Jeroen
name: Grimm, Oliver
name: Schork, Andrew J.
name: Lovestone, Simon
name: Stott, David J.
name: Stein, Jason L.
name: Duggirala, Ravi
name: Walter, Henrik
name: Ikeda, Masashi
name: Nauck, Matthias
name: Ryten, Mina
name: Giddaluru, Sudheer
name: Melle, Ingrid
name: Kochunov, Peter
name: Nho, Kwangsik
name: Brouwer, Rachel M.
name: Strike, Lachlan T.
name: Haukvik, Unn K.
name: Yang, Jingyun
name: Kim, Sungeun
name: Oosterlaan, Jaap
name: Kwok, John B.
name: Bis, Joshua C.
name: Lawrie, Stephen M.
name: De Craen, Anton J. M.
name: Barral, Sandra
name: Martinot, Jean-Luc
name: Ferrucci, Luigi
name: Hashimoto, Ryota
name: Seshadri, Sudha
name: Müller-Myhsok, Bertram
name: Gudnason, Vilmundur
name: Vernooij, Meike W.
name: Chen, Qiang
name: White, Tonya
name: Amouyel, Philippe
name: Tordesillas-Gutierrez, Diana
name: Westman, Eric
name: Beiser, Alexa
name: Trompet, Stella
name: Hoekstra, Pieter J.
name: Nyquist, Paul
name: Schmidt, Reinhold
name: Launer, Lenore J.
name: Fedko, Iryna O.
name: Rundek, Tatjana
name: Cookson, Mark R.
name: Ramasamy, Adaikalavan
name: Toro, Roberto
name: Ehrlich, Stefan
name: De Zubicaray, Greig I.
name: Mather, Karen A.
name: Wen, Wei
name: Pütz, Benno
name: Goldman, Aaron L.
name: Muñoz Maniega, Susana
name: Brickman, Adam M.
name: Arfanakis, Konstantinos
name: Doan, Nhat Trung
name: Wolf, Christiane
name: Wong, Tien Y.
name: Ohi, Kazutaka
name: Uitterlinden, Andre G.
name: Glahn, David C.
name: Weinberger, Daniel R.
name: Jahanshad, Neda
name: Hofer, Edith
name: Nöthen, Markus M.
name: Franke, Barbara
name: Drevets, Wayne C.
name: Nichols, Thomas E.
name: Vellas, Bruno
name: Rietschel, Marcella
name: Becker, Diane M.
name: Traynor, Bryan J.
name: Ames, David
name: Hardy, John
name: Van Der Brug, Marcel
name: Lopez, Oscar L.
name: Ikram, M. Arfan
name: Heslenfeld, Dirk J.
name: Thompson, Paul M.
name: Ho, Beng-Choon
name: Den Braber, Anouk
name: Paus, Tomas
name: Grabe, Hans J.
name: Pol, Hilleke E. Hulshoff
name: Teumer, Alexander
name: Håberg, Asta K.
name: Schmaal, Lianne
name: Matarin, Mar
name: Potkin, Steven G.
name: Armstrong, Nicola J.
name: Van Der Lee, Sven J.
name: Agartz, Ingrid
name: Blanton, Susan H.
name: Djurovic, Srdjan
name: Janowitz, Deborah
name: Sussmann, Jessika E.
name: Fornage, Myriam
name: Tzourio, Christophe
name: Boomsma, Dorret I.
name: Green, Robert C.
name: Liewald, David C. M.
name: Van Der Lugt, Aad
name: Arias-Vasquez, Alejandro
name: Destefano, Anita
name: Chauhan, Ganesh
name: Abramovic, Lucija
name: Crespo-Facorro, Benedicto
name: Fisher, Simon E.
name: Decarli, Charles
name: Kanai, Ryota
name: Andreassen, Ole A.
name: Mohnke, Sebastian
name: Windham, Beverly G.
name: Olvera, Rene L.
name: Wardlaw, Joanna M.
name: Nyberg, Lars
name: Assareh, Amelia A.
name: Psaty, Bruce M.
name: Depondt, Chantal
name: Corvin, Aiden
name: Erk, Susanne
name: Hernandez, Dena G.
name: Ophoff, Roel A.
name: Risacher, Shannon L.
name: Mattay, Venkata S.
name: Rotter, Jerome I.
name: McKay, David R.
name: Marquand, Andre F.
name: Trabzuni, Daniah
name: Sacco, Ralph L.
name: Jönsson, Erik G.
name: Bernard, Manon
name: Czisch, Michael
name: Nugent, Allison C.
name: Buckner, Randy L.
name: Simmons, Andrew
name: Sigursson, Sigurdur
name: Steen, Vidar M.
name: Weiner, Michael W.
name: Roiz-Santiañez, Roberto
name: Aribisala, Benjamin S.
name: Ropele, Stefan
name: Martin, Nicholas G.
name: Thalamuthu, Anbupalam
name: Dale, Anders M.
name: Papmeyer, Martina
name: Espeseth, Thomas
name: Van Donkelaar, Marjolein M. J.
name: Renteria, Miguel E.
name: Cavalleri, Gianpiero L.
name: Van Der Wee, Nic J. A.
name: Montgomery, Grant W.
name: Donohoe, Gary
name: Saremi, Arvin
name: Zielke, Ronald H.
name: Gollub, Randy L.
name: Mecocci, Patrizia
name: Van Bokhoven, Hans
name: Meyer-Lindenberg, Andreas
name: Dyer, Thomas D.
name: Ford, Ian
name: Holmes, Avram J.
name: Shumskaya, Elena
name: Niessen, Wiro J.
name: Pike, G. Bruce
name: Jia, Tianye
name: Winkler, Anderson M.
name: Royle, Natalie A.
name: Amin, Najaf
name: Cheng, Ching-Yu
name: Debette, Stéphanie
name: Van Rooij, Daan
name: Heinz, Andreas
name: Bastin, Mark E.
name: Wright, Clinton B.
name: Fukunaga, Masaki
name: Buitelaar, Jan K.
name: Loohuis, Loes M. Olde
name: Nalls, Michael A.
name: Longo, Dan L.
name: De Geus, Eco J. C.
name: Roffman, Joshua L.
name: Curran, Joanne E.
name: Hass, Johanna
name: Karbalai, Nazanin
name: Delanty, Norman
name: Van Eijk, Kristel R.
name: Saykin, Andrew J.
name: Jukema, J. Wouter
name: Francks, Clyde
name: Hartman, Catharina A.
name: Göring, Harald H. H.
name: Ikram, M. Kamran
name: Chakravarty, M. Mallar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.