cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity
Creators: name: Xiong, Y.
name: Franklin, D. S.
name: Godfrey, V. L.
name: Deng, C.
name: O'Brien, D. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The presence of two families of seven distinct mammalian cyclin-dependent kinase (CDK) inhibitor genes is thought to mediate the complexity of connecting a variety of cellular processes to the cell cycle control pathway. The distinct pattern of tissue expression of CDK inhibitor genes suggests that they may function as tumor suppressors with different tissue specificities. To test this hypothesis, we have characterized two strains of double mutant mice lacking either p18INK4c and p27KIP1 or p18INK4c and p21CIP1/WAF1. Loss of both p18 and p27 function resulted in the spontaneous development by 3 months of age of at least eight different types of hyperplastic tissues and/or tumors in the pituitary, adrenals, thyroid, parathyroid, testes, pancreas, duodenum, and stomach. Six of these hyperplastic tissues and tumors were in endocrine organs, and several types of tumors routinely developed within the same animal, a phenotype reminiscent of that seen in combined human multiple endocrine neoplasia syndromes. The p18-p21 double null mice, on the other hand, developed pituitary adenomas, multifocal gastric neuroendocrine hyperplasia, and lung bronchioalveolar tumors later in life. G1 CDK2 and CDK4 kinase activities were increased in both normal and neoplastic tissues derived from mice lacking individual CDK inhibitors and were synergistically stimulated by the simultaneous loss of two CDK inhibitors. This indicates that an increase in G1 CDK kinase activity is a critical step during but is not sufficient for tumor growth. Our results suggest that functional collaborations between distinct CDK inhibitor genes are tissue specific and confer yet another level of regulation in cell growth control and tumor suppression.
Amputation : le patient face à sa nouvelle image corporelle
Creators: name: Couto, Alexia
name: Siro, Antonella
Publisher: name: Unknown
Year: 0
Subjects: subject: amputation
subject: image corporelle
subject: patient
subject: acceptation

description: Question de recherche et contexte: Cette revue littéraire cherche à expliquer quelles stratégies d’adaptation, les personnes ayant subi l’amputation d’un membre, mettent en place pendant le processus d’intégration de leur nouvelle image corporelle ; quelle place l’infirmière occupe dans ce processus et quelles sont ses interventions pour que ce processus s’entame efficacement. Nous avons choisi la question de recherche suivante : « Comment l’infirmière peut-elle accompagner vers l’intégration de sa nouvelle image corporelle, un adulte ayant subi l’amputation d’un membre ?
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Electronic Density Response of Warm Dense Matter
Creators: name: Dornheim, Tobias
name: Moldabekov, Zhandos A.
name: Ramakrishna, Kushal
name: Tolias, Panagiotis
name: Baczewski, Andrew D.
name: Kraus, Dominik
name: Preston, Thomas R.
name: Chapman, David A.
name: Böhme, Maximilian P.
name: Döppner, Tilo
name: Graziani, Frank
name: Bonitz, Michael
name: Cangi, Attila
name: Vorberger, Jan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Matter at extreme temperatures and pressures -- commonly known as warm dense matter (WDM) in the literature -- is ubiquitous throughout our Universe and occurs in a number of astrophysical objects such as giant planet interiors and brown dwarfs. Moreover, WDM is very important for technological applications such as inertial confinement fusion, and is realized in the laboratory using different techniques. A particularly important property for the understanding of WDM is given by its electronic density response to an external perturbation. Such response properties are routinely probed in x-ray Thomson scattering (XRTS) experiments, and, in addition, are central for the theoretical description of WDM. In this work, we give an overview of a number of recent developments in this field. To this end, we summarize the relevant theoretical background, covering the regime of linear-response theory as well as nonlinear effects, the fully dynamic response and its static, time-independent limit, and the connection between density response properties and imaginary-time correlation functions (ITCF). In addition, we introduce the most important numerical simulation techniques including ab initio path integral Monte Carlo (PIMC) simulations and different thermal density functional theory (DFT) approaches. From a practical perspective, we present a variety of simulation results for different density response properties, covering the archetypal model of the uniform electron gas and realistic WDM systems such as hydrogen. Moreover, we show how the concept of ITCFs can be used to infer the temperature from XRTS measurements of arbitrarily complex systems without the need for any models or approximations. Finally, we outline a strategy for future developments based on the close interplay between simulations and experiments.
Microstructural pattern formation during liquid metal dealloying: Phase-field simulations and theoretical analyses
Creators: name: Lai, Longhai
name: Geslin, Pierre-Antoine
name: Karma, Alain
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: In recent years, liquid metal dealloying (LMD) has emerged as a promising material processing method to generate micro and nano-scale bicontinuous or porous structures. Most previous studies focused on the experimental characterization of the dealloying process and on the properties of the dealloyed materials, leaving the theoretical study incomplete to fully understand the fundamental mechanisms of LMD. In this paper, we use theoretical models and phase-field simulations to clarify the kinetics and pattern formation during LMD. Our study starts from a theoretical analysis of the 1D dissolution of a binary precursor alloy, which reveals that the 1D dissolution process involves two regimes. In the first regime, due to the low solubility of one of the elements in the melt, it accumulates at the solid-liquid interface, which reduces the dissolution kinetics. In the second regime, the interface kinetics reaches a stationary regime where both elements of the precursor alloy dissolve into the melt. Previous works revealed that in the early dealloying stage, the dealloying front is destabilized by an interfacial spinodal decomposition, which triggers the formation of interconnected ligaments. We extend this line of work by proposing a linear stability analysis able to predict the initial length-scale of the ligaments formed in the initial stage of the dealloying. Combining this analysis with the 1D dissolution model proposed here enables us to better understand the initial conditions (composition of the precursor alloy and the melt) leading to a planar dissolution without interface destabilization. Finally, we report a strong influence of solid-state diffusion on dealloying that was overlooked in previous studies. Although the solid-state diffusivity is four to five orders of magnitude smaller than in the liquid phase, it is found to affect both dissolution kinetics and ligament morphologies.
description: 24 pages, 27 figures
title: Agitation des résidents d'établissements médico-sociaux atteints de troubles cognitifs de type démentiel
title: et si on essayait autre chose que les neuroleptiques ?
titleType: Subtitle
Creators: name: Corday, Sophie
name: Germanier, Caroline
Publisher: name: Unknown
Year: 0
Subjects: subject: établissements médico-sociaux
subject: troubles cognitifs
subject: démence
subject: personne âgée
subject: neuroleptiques

description: Suite au vieillissement démographique, de plus en plus de personnes âgées seront atteintes de troubles cognitifs de type démentiel. Ces troubles sont souvent accompagnés de symptômes psychologiques et comportementaux qui rendent la prise en soin difficile. Parmi ces troubles, nous avons choisi de nous centrer sur l’agitation, qui est un facteur de stress pour les soignants et pourrait être la cause de mauvais traitements. De plus, elle est souvent traitée par des neuroleptiques, lesquels ont de nombreux effets indésirables. Or, il existe plusieurs approches non-médicamenteuses
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Identification and Characterization of an Activating TrkA Deletion Mutation in Acute Myeloid Leukemia
Creators: name: Caligiuri, M. A.
name: Lambert, Q. T.
name: Der, C. J.
name: Reuther, G. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: In this study, we utilized retroviral transfer of cDNA libraries in order to identify oncogenes that are expressed in acute myeloid leukemia (AML). From screens using two different cell types as targets for cellular transformation, a single cDNA encoding a variant of the TrkA protooncogene was isolated. The protein product of this protooncogene, TrkA, is a receptor tyrosine kinase for nerve growth factor. The isolated transforming cDNA encoded a TrkA protein that contains a 75-amino-acid deletion in the extracellular domain of the receptor and was named ΔTrkA. ΔTrkA readily transformed fibroblast and epithelial cell lines. The deletion resulted in activation of the tyrosine kinase domain leading to constitutive tyrosine phosphorylation of the protein. Expression of ΔTrkA in cells led to the constitutive activation of intracellular signaling pathways that include Ras, extracellular signal-regulated kinase/mitogen-activated protein kinase, and Akt. Importantly, ΔTrkA altered the apoptotic and growth properties of 32D myeloid progenitor cells, suggesting ΔTrkA may have contributed to the development and/or maintenance of the myeloid leukemia from which it was isolated. Unlike Bcr-Abl, expression of ΔTrkA did not activate Stat5 in these cells. We have detected expression of ΔTrkA in the original AML sample by reverse transcriptase PCR and by Western blot analysis. While previous TrkA mutations identified from human tumors involved fusion to other proteins, this report is the initial demonstration that deletions within TrkA may play a role in human cancers. Finally, this report is the first to indicate mutations in TrkA may contribute to leukemogenesis.
On the role of technology in human-dog relationships: a future of nightmares or dreams?
Creators: name: van der Linden, Dirk
name: Davidson, Brittany I.
name: Hirsch-Matsioulas, Orit
name: Zamansky, Anna
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Digital technologies that help people take care of their dogs are becoming more widespread. Yet, little research explores what the role of technology in the human-dog relationship should be. We conducted a qualitative study incorporating quantitative and thematic analysis of 155 UK dog owners reflecting on their daily routines and technology's role in it, disentangling the what-where-why of interspecies routines and activities, technological desires, and rationales for technological support across common human-dog activities. We found that increasingly entangled daily routines lead to close multi-species households where dog owners conceptualize technology as having a role to support them in giving care to their dogs. When confronted with the role of technology across various activities, only chores like cleaning up after their dogs lead to largely positive considerations, while activities that benefit themselves like walking together lead to largely negative considerations. For other activities, whether playing, training, or feeding, attitudes remain diverse. In general, across all activities both a nightmare scenario of technology taking the human's role and in doing so disentangling the human-dog bond, as well as a dream scenario of technology augmenting human abilities arise. We argue that the current trajectory of digital technology for pets is increasingly focused on enabling remote interactions, an example of the nightmare scenario in our thematic analysis. It is important to redirect this trajectory to one of technology predominantly supporting us in becoming better and more informed caregivers.
Dans une perspective infirmière, comment pouvons-nous orienter et améliorer la qualité de l'accompagnement aux parents ayant un enfant en soins palliatifs?
Creators: name: Conod, Nathalie
name: Orsino, Cinzia
Publisher: name: Unknown
Year: 0
Subjects: subject: qualité des soins, accompagnement, relation soignant-famille, enfant, soins palliatifs

description: Nous avons décidé d’axer notre travail sur l’accompagnement des parents ayant un enfant en soins palliatifs. Le cancer étant une des premières causes de mortalité infantiles, il provoque en Suisse environ 25 décès par année d’enfants de moins de 5 ans et près de 200 nouveaux enfants diagnostiqués chaque année. La prise en soin de l’enfant malade s’oriente également en grande partie avec et autour de ses parents et de son entourage. L’équipe interdisciplinaire doit non seulement prendre en compte les parents dans celle-ci mais doit également les soutenir et les accompagner tout au long de la maladie. Dans le canton de Vaud, l’équipe de soins palliatifs pédiatriques est aussi amenée à intervenir après le décès
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Increased Rates of Genomic Deletions Generated by Mutations in the Yeast Gene Encoding DNA Polymerase delta or by Decreases in the Cellular Levels of DNA Polymerase delta
Creators: name: Kokoska, R. J.
name: Petes, T. D.
name: Stefanovic, L.
name: DeMai, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: In Saccharomyces cerevisiae, POL3 encodes the catalytic subunit of DNA polymerase δ. While yeast POL3 mutant strains that lack the proofreading exonuclease activity of the polymerase have a strong mutator phenotype, little is known regarding the role of other Pol3p domains in mutation avoidance. We identified a number of pol3 mutations in regions outside of the exonuclease domain that have a mutator phenotype, substantially elevating the frequency of deletions. These deletions appear to reflect an increased frequency of DNA polymerase slippage. In addition, we demonstrate that reduction in the level of wild-type DNA polymerase results in a similar mutator phenotype. Lowered levels of DNA polymerase also result in increased sensitivity to the DNA-damaging agent methyl methane sulfonate. We conclude that both the quantity and the quality of DNA polymerase δ is important in ensuring genome stability.
Quality Management at Research Data Repositories. Results from a survey and Framework of Quality Assurance for Data Publications at Research Data Repositories
Creators: name: Kindling, Maxi
name: Strecker, Dorothea
Publisher: name: Zenodo
Year: 2022
Subjects: research data repository
research data quality
survey

description: The slides were presented at the re3data COREF / CoreTrustSeal Workshop on Data Quality Management at Repositories that took place on October 5, 2022, 12:00-15:30 UTC.
 The workshop featured perspectives on data quality assurance from research data repositories, the certification organization CoreTrustSeal, and the registry of research data repositories re3data. Presentations showcased measures research data repositories undertake to ensure data quality, with the objective to share experiences, raise awareness and make the various activities repositories perform to assure, assess, and improve data quality visible.
 These slides present results of a survey on research data quality assurance at repositories conducted in 2021 as part of the re3data COREF project, and introduce a Framework of Quality Assurance for Data Publications at Research Data Repositories.
Extending the $L_{\mathrm{X}}-T$ relation from clusters to groups-Impact of cool core nature, AGN feedback, and selection effects
Creators: name: Bharadwaj, V.
name: Reiprich, T. H.
name: Lovisari, L.
name: Eckmiller, H. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We aim to investigate the bolometric $L_{\mathrm{X}}-T$ relation for galaxy groups, and study the impact of gas cooling, feedback from supermassive black holes, and selection effects on it. With a sample of 26 galaxy groups we obtained the best fit $L_{\mathrm{X}}-T$ relation for five different cases depending on the ICM core properties and central AGN radio emission, and determined the slopes, normalisations, intrinsic and statistical scatters for both temperature and luminosity. Simulations were undertaken to correct for selection effects (e.g. Malmquist bias) and the bias corrected relations for groups and clusters were compared. The slope of the bias corrected $L_{\mathrm{X}}-T$ relation is marginally steeper but consistent with clusters ($\sim 3$). Groups with a central cooling time less than 1 Gyr (SCC groups) show indications of having the steepest slope and the highest normalisation. For the groups, the bias corrected intrinsic scatter in $L_{\mathrm{X}}$ is larger than the observed scatter for most cases, which is reported here for the first time. Lastly, we see indications that the groups with an extended central radio source have a much steeper slope than those groups which have a CRS with only core emission. Additionally, we also see indications that the more powerful radio AGN are preferentially located in NSCC groups rather than SCC groups.
description: Accepted for publication in Astronomy and Astrophysics
title: Développer une culture thérapeutique dans un univers stressant, idéal ou possibilité ?
title: un exemple en unité de soins palliatifs basé sur la théorie du soin centré sur la personne
titleType: Subtitle
Creators: name: Chavey, Florence
name: Scuderi, Luca
Publisher: name: Unknown
Year: 0
Subjects: subject: profession infirmière
subject: stress
subject: culture thérapeutique
subject: soins palliatifs
subject: soin centré sur la personne

description: La thématique du stress est omniprésente dans les milieux de soin, en relation avec un nombre important de stresseurs de natures différentes. Ayant fait ce constat à travers la littérature et ayant expérimenté le stress sur nos lieux de stage nous nous sommes questionnés sur l’impact de ce dernier sur la relation avec le patient dans le soin. Pour agrémenter notre réflexion, nous nous sommes appuyés sur la théorie du soin centré sur la personne (SCP) proposée par McCance et McCormack (2006). Cette théorie propose le concept de culture thérapeutique définie comme un moment de rencontre dans le soin bénéfique pour le soignant et le patient comme étant une plus-value de la mise en place du SCP. Nous nous sommes dès lors demandé s’il était possible de développer cette culture thérapeutique dans un environnement stressant.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Equivariant Filter Design for Inertial Navigation Systems with Input Measurement Biases
Creators: name: Fornasier, Alessandro
name: Ng, Yonhon
name: Mahony, Robert
name: Weiss, Stephan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Inertial Navigation Systems (INS) are a key technology for autonomous vehicles applications. Recent advances in estimation and filter design for the INS problem have exploited geometry and symmetry to overcome limitations of the classical Extended Kalman Filter (EKF) approach that formed the mainstay of INS systems since the mid-twentieth century. The industry standard INS filter, the Multiplicative Extended Kalman Filter (MEKF), uses a geometric construction for attitude estimation coupled with classical Euclidean construction for position, velocity and bias estimation. The recent Invariant Extended Kalman Filter (IEKF) provides a geometric framework for the full navigation states, integrating attitude, position and velocity, but still uses the classical Euclidean construction to model the bias states. In this paper, we use the recently proposed Equivariant Filter (EqF) framework to derive a novel observer for biased inertial-based navigation in a fully geometric framework. The introduction of virtual velocity inputs with associated virtual bias leads to a full equivariant symmetry on the augmented system. The resulting filter performance is evaluated with both simulated and real-world data, and demonstrates increased robustness to a wide range of erroneous initial conditions, and improved accuracy when compared with the industry standard Multiplicative EKF (MEKF) approach.
title: Douleur aux urgences
title: rôle infirmier et recommandations de bonne pratique
titleType: Subtitle
Creators: name: Buletti, Martina
name: Vacherand, Virginie
Publisher: name: Unknown
Year: 0
Subjects: subject: douleur
subject: urgence, rôle infirmier
subject: recommandations

description: Dans le contexte des urgences, la douleur représente une problématique de santé importante puisque près de 80% des patients consultent pour cette raison. Depuis de nombreuses années, des études montrent que la prise en charge de la douleur aux urgences est sous-optimale et que la majorité des patients continue à ressentir de la douleur à sa sortie de l’hôpital. L’infirmier ayant un rôle important à jouer dans la prise en charge de la douleur des patients, en particulier dans ce contexte, nous nous sommes questionnées sur la manière d’optimiser la prise en charge de la douleur. Cette revue de littérature, ciblée sur la prise en charge de la douleur aiguë de patients adultes, vise à répondre à cette question. Huit articles scientifiques ont été sélectionnés dans des bases de données et analysés, puis leurs résultats ont été comparés et discutés afin d’en déduire des recommandations de bonne pratique.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Learning Trivializing Gradient Flows for Lattice Gauge Theories
Creators: name: Bacchio, Simone
name: Kessel, Pan
name: Schaefer, Stefan
name: Vaitl, Lorenz
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We propose a unifying approach that starts from the perturbative construction of trivializing maps by Lüscher and then improves on it by learning. The resulting continuous normalizing flow model can be implemented using common tools of lattice field theory and requires several orders of magnitude fewer parameters than any existing machine learning approach. Specifically, our model can achieve competitive performance with as few as 14 parameters while existing deep-learning models have around 1 million parameters for $SU(3)$ Yang--Mills theory on a $16^2$ lattice. This has obvious consequences for training speed and interpretability. It also provides a plausible path for scaling machine-learning approaches toward realistic theories.
description: 10 pages, 4 figures, 1 table
A trivariate interpolation algorithm using a cube-partition searching procedure
Creators: name: Cavoretto, Roberto
name: De Rossi, Alessandra
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper we propose a fast algorithm for trivariate interpolation, which is based on the partition of unity method for constructing a global interpolant by blending local radial basis function interpolants and using locally supported weight functions. The partition of unity algorithm is efficiently implemented and optimized by connecting the method with an effective cube-partition searching procedure. More precisely, we construct a cube structure, which partitions the domain and strictly depends on the size of its subdomains, so that the new searching procedure and, accordingly, the resulting algorithm enable us to efficiently deal with a large number of nodes. Complexity analysis and numerical experiments show high efficiency and accuracy of the proposed interpolation algorithm.
Data Quality Assurance from the Perspective of CoreTrustSeal
Creators: name: L'Hours, Herve
Publisher: name: Zenodo
Year: 2022
Subjects: CoreTrustSeal, TDR, Data Quality, Preservation

description: The slides were presented at the re3data COREF / CoreTrustSeal Workshop on Data Quality Management at Repositories that took place on October 5, 2022, 12:00-15:30 UTC.
 The workshop featured perspectives on data quality assurance from research data repositories, the certification organization CoreTrustSeal, and the registry of research data repositories re3data. Presentations showcased measures research data repositories undertake to ensure data quality, with the objective to share experiences, raise awareness and make the various activities repositories perform to assure, assess, and improve data quality visible. These slides focus on the issues of data quality from the perspective of the CoreTrustSeal Requirements and Certification Process.
Involvement of the Checkpoint Protein Mec1p in Silencing of Gene Expression at Telomeres in Saccharomyces cerevisiae
Creators: name: Petes, T. D.
name: Craven, R. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Yeast strains with a mutation in the MEC1 gene are deficient in the cellular checkpoint response to DNA-damaging agents and have short telomeres (K. B. Ritchie, J. C. Mallory, and T. D. Petes, Mol. Cell. Biol. 19:6065–6075, 1999; T. A. Weinert, G. L. Kiser, and L. H. Hartwell, Genes Dev. 8:652–665, 1994). In wild-type yeast cells, genes inserted near the telomeres are transcriptionally silenced (D. E. Gottschling, O. M. Aparichio, B. L. Billington, and V. A. Zakian, Cell 63:751–762, 1990). We show that mec1 strains have reduced ability to silence gene expression near the telomere. This deficiency was alleviated by the sml1 mutation. Overexpression of Mec1p also resulted in a silencing defect, although this overexpression did not affect the checkpoint function of Mec1p. Telomeric silencing was not affected by mutations in several other genes in the Mec1p checkpoint pathway (null mutations in RAD9 and CHK1 or in several hypomorphic rad53 alleles) but was reduced by a null mutation of DUN1. In addition, the loss of telomeric silencing in mec1 strains was not a consequence of the slightly shortened telomeres observed in these strains.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Il libro di Giose Rimanelli, Graffiti, è un testo incredibilmente difficile che facilmente disorienta e fuorvia il lettore inesperto. Fluttua tra due universi distinti che mostrano le somiglianze di ciascuno: conflitti politici, economici e sociali verificatisi in Italia all'inizio del XX secolo e, successivamente, negli Stati Uniti tra la metà e la fine del XX. Ogni periodo porta il loro paese su un percorso di rivolta civile. L'autore offre inquadrature cinematografiche che presentano uno spaccato della negatività culturale che si verifica all'interno del paese. Queste singole immagini si combineranno e creeranno una versione contemporanea di una proiezione zoopraxiscopica di un periodo specifico: la metà degli anni ‘60.
description: Giose Rimanelli’s book, Graffiti, is an incredibly difficult text that easily mystifies and misleads the inexperienced reader. It fluctuates between two distinct universes showing the similarities of each: political, economic, and societal strife in Italy in the early 20th Century, and, later in the United States during the mid to late 20th. Each period takes their country down the path of civil revolt. The author offers cinematographic frames that present a glimpse of the cultural negativity occur ring within the country. These individual images will combine and create a contemporary version of a zoopraxiscope projection of a specific period: the mid-1960s.
Cuckoo Search: A Brief Literature Review
Creators: name: Fister, I.
name: Yang, X. S.
name: Fister, D.
name: Fister, I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Neural and Evolutionary Computing (cs.NE)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: 90C26

description: Cuckoo search (CS) was introduced in 2009, and it has attracted great attention due to its promising efficiency in solving many optimization problems and real-world applications. In the last few years, many papers have been published regarding cuckoo search, and the relevant literature has expanded significantly. This chapter summarizes briefly the majority of the literature about cuckoo search in peer-reviewed journals and conferences found so far. These references can be systematically classified into appropriate categories, which can be used as a basis for further research.
description: 14 pages 3 figures
A tale of a rich cluster at z$\sim$0.8 as seen by the Star Formation Histories of its ETGs
Creators: name: Ferré-Mateu, Anna
name: Sánchez-Blázquez, Patricia
name: Vazdekis, Alexandre
name: de la Rosa, Ignacio G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a detailed stellar population analysis for a sample of 24 early-type galaxies belonging to the rich cluster RXJ0152.7-1357 at z=0.83. We have derived the age, metallicity, abundance pattern and star formation history for each galaxy individually, to further characterize this intermediate-z reference cluster. We then study how these stellar population parameters depend on local environment. This provides a better understanding on the formation timescales and subsequent evolution of the substructures in this cluster. We have also explored the evolutionary link between z$\sim$0.8 ETGs and those in the local Universe by comparing the trends that the stellar population parameters follow with galaxy velocity dispersion at each epoch. We find that the ETGs in Coma are consistent with being the (passively-evolving) descendants of the ETG population in RXJ10152.7-1357. Furthermore, our results favor a downsizing picture, where the subclumps centers were formed first. This central parts contain the most massive galaxies, which formed the bulk of their stars in a short, burst-like event at high-z. On the contrary, the cluster outskirts are populated with less massive, smaller galaxies, which show a wider variety of Star Formation Histories. In general, they present extended star formation episodes over cosmic time, which seems to be related to their posterior incorporation into the cluster, around 4Gyr later after the initial event of formation.
description: 22 pages, 20 Figures. Accepted for publication in ApJ
How dirt cones form on glaciers: field observation, laboratory experiments and modeling
Creators: name: Hénot, Marceau
name: Langlois, Vincent J.
name: Plihon, Nicolas
name: Taberlet, Nicolas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Dirt cones are meter-scale structures encountered at the surface of glaciers, which consist of ice cones covered by a thin layer of ashes, sand or gravel, and which form naturally from an initial patch of debris. In this article, we report field observations of cone formation in the French Alps, laboratory-scale experiments reproducing these structures in a controlled environment, and two-dimensional discrete-element-method-finite-element-method numerical simulations coupling the grains mechanics and thermal effects. We show that cone formation originates from the insulating properties of the granular layer, which reduces ice melting underneath as compared to bare ice melting. This differential ablation deforms the ice surface and induces a quasi static flow of grains that leads to a conic shape, as the thermal length become small compared to the structure size. The cone grows until it reaches a steady state in which the insulation provided by the dirt layer exactly compensates for the heat flux coming from the increased external surface of the structure. These results allowed us to identify the key physical mechanisms at play and to develop a model able to quantitatively reproduce the various field observations and experimental findings.
description: 10 pages, 8 figures, and supplementary materials (6 pages, 5 figures)
A relativistic mean field study of multi-strange system
Creators: name: Ikram, M.
name: Singh, S. K.
name: Usmani, A. A.
name: Patra, S. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study the binding energies, radii, single-particle energies, spin-orbit potential and density profile for multi-strange hypernuclei in the range of light mass to superheavy region within the relativistic mean field (RMF) theory. The stability of multi-strange hypernuclei as a function of introduced hyperons ($Λ$ and $Σ$) is investigated. The neutron, lambda and sigma mean potentials are presented for light to superheavy hypernuclei. The inclusion of hyperons affects the nucleon, lambda and sigma spin-orbit potentials significantly. The bubble structure of nuclei and corresponding hypernuclei is studied. The nucleon and lambda halo structure are also investigated. A large class of bound multi-strange systems formed from the combination of nucleons and hyperons (n, p, $Λ$, $Σ^+$ and n, p, $Λ$, $Σ^-$) is suggested in the region of superheavy hypernuclei which might be stable against the strong decay. These multi-strange systems might be produced in heavy-ion reactions.
description: 13 pages, 14 figures, 4 tables
title: Notre nouveau-né prématuré rentre à la maison
title: une transition pour les parents, une responsabilité pour le personnel infirmier
titleType: Subtitle
Creators: name: Buffet, Christelle
name: Mermoud, Françoise
Publisher: name: Unknown
Year: 0
Subjects: subject: nouveau-né
subject: prématuré
subject: retour à domicile
subject: accompagnement
subject: parents
subject: rôle infirmier

description: Le vécu des parents et le rôle infirmier dans la préparation du retour à domicile de l'enfant prématuré sont deux éléments approfondis dans cette revue de littérature. Nous avons pris appui sur un ancrage disciplinaire et structuré ce travail avec la théorie de la transition de Meleis (2000).
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Study of a viscous $Λ$WDM model: Near equilibrium condition, entropy production, and cosmological constraints
Creators: name: Cruz, Norman
name: González, Esteban
name: Jovel, Jose
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Extensions to a $Λ$DM model have been explored to face current tensions that occur within its framework, which encompasses broadening the nature of the dark matter (DM) component to include warmness and a non-perfect fluid description. In this paper, we investigated the late-time cosmological evolution of an exact solution recently found in [N. Cruz, E. González, and J. Jovel, Phys. Rev. D \textbf{105}, 024047 (2022)], which describe a viscous warm $Λ$DM model ($Λ$WDM) with a DM component that obeys a polytropic equation of state (EoS), which experience dissipative effects with a bulk viscosity proportional to its energy density, with proportionality constant $ξ_{0}$. This solution has the particularity of having a very similar behavior to the $Λ$CDM model for small values of $ξ_{0}$, evolving also to a de Sitter type expansion in the very far future. We explore firstly the thermodynamic consistences of this solution in the framework of the Eckart's theory of non-perfect fluids, focusing on the fulfillment of the two following conditions: (i) the near equilibrium condition and (ii) the positiveness of the entropy production. We explore the range of parameters of the model that allow to fulfilling these two conditions at the same time, finding that a viscous WDM component is compatible with both ones, being in this sense, a viable model from the thermodynamic point of view. Besides, we constraint the free parameters of the model with the observational data coming form supernovae Ia (SNe Ia) and the observational Hubble parameter data (OHD).(Abridged)
description: 16 pages, 6 figures
title: Le patient difficile en santé mentale
title: un challenge pour les équipes infirmières
titleType: Subtitle
Creators: name: Breitschmid, Emilie
Publisher: name: Unknown
Year: 0
Subjects: subject: psychiatrie
subject: état-limite
subject: borderline
subject: patient difficile
subject: alliance thérapeutique

description: La problématique de cette revue de littérature aborde le thème du patient désigné comme étant ‘difficile’ en psychiatrie. Cette appellation couramment utilisée dans le domaine de la santé mentale, renvoie généralement aux personnes atteintes du trouble de la personnalité borderline. Cette désignation qui nourrit bien souvent les préjugés et les attitudes négatives, camoufle généralement la souffrance réelle du patient. Trois concepts y sont développés, il s’agit du prendre soin, de l’alliance thérapeutique et du patient difficile.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends
Creators: name: Nick McElhinny, S. A.
name: McCarville, J.
name: Snowden, C. M.
name: Ramsden, D. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Genetic experiments have determined that Ku, XRCC4, and ligase IV are required for repair of double-strand breaks by the end-joining pathway. The last two factors form a tight complex in cells. However, ligase IV is only one of three known mammalian ligases and is intrinsically the least active in intermolecular ligation; thus, the biochemical basis for requiring this ligase has been unclear. We demonstrate here a direct physical interaction between the XRCC4-ligase IV complex and Ku. This interaction is stimulated once Ku binds to DNA ends. Since XRCC4-ligase IV alone has very low DNA binding activity, Ku is required for effective recruitment of this ligase to DNA ends. We further show that this recruitment is critical for efficient end-joining activity in vitro. Preformation of a complex containing Ku and XRCC4-ligase IV increases the initial ligation rate 20-fold, indicating that recruitment of the ligase is an important limiting step in intermolecular ligation. Recruitment by Ku also allows XRCC4-ligase IV to use Ku's high affinity for DNA ends to rapidly locate and ligate ends in an excess of unbroken DNA, a necessity for end joining in cells. These properties are conferred only on ligase IV, because Ku does not similarly interact with the other mammalian ligases. We have therefore defined cell-free conditions that reflect the genetic requirement for ligase IV in cellular end joining and consequently can explain in molecular terms why this factor is required.
Electromagnetic energy loss of axion stars
Creators: name: Patkos, Andras
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The rate of energy exchange of spatially localized and gravitationally bound axion configurations with electromagnetic radiation is investigated in presence of strong static magnetic field. Fully analytic treatment is achieved based on variationally optimized separable spatio-temporal clump profiles. For dilute axion stars the equation of the energy variation is reinterpreted as a rate equation of the axion number. Its solutions hints to an asymptotic $\sim t^{1/5}$ increase of the clump size.
description: 6 pages; extended version to appear in Physical Review D
Stem-Loop Binding Protein, the Protein That Binds the 3' End of Histone mRNA, Is Cell Cycle Regulated by Both Translational and Posttranslational Mechanisms
Creators: name: Zheng, L.-X.
name: Hurt, M. M.
name: Whitfield, M. L.
name: Ohta, T.
name: Baldwin, A.
name: Marzluff, W. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The expression of the replication-dependent histone mRNAs is tightly regulated during the cell cycle. As cells progress from G1 to S phase, histone mRNA levels increase 35-fold, and they decrease again during G2 phase. Replication-dependent histone mRNAs are the only metazoan mRNAs that lack polyadenylated tails, ending instead in a conserved stem-loop. Much of the cell cycle regulation is posttranscriptional and is mediated by the 3′ stem-loop. A 31-kDa stem-loop binding protein (SLBP) binds the 3′ end of histone mRNA. The SLBP is necessary for pre-mRNA processing and accompanies the histone mRNA to the cytoplasm, where it is a component of the histone messenger RNP. We used synchronous CHO cells selected by mitotic shakeoff and HeLa cells synchronized at the G1/S or the M/G1 boundary to study the regulation of SLBP during the cell cycle. In each system the amount of SLBP is regulated during the cell cycle, increasing 10- to 20-fold in the late G1 and then decreasing in the S/G2 border. SLBP mRNA levels are constant during the cell cycle. SLBP is regulated at the level of translation as cells progress from G1 to S phase, and the protein is rapidly degraded as they progress into G2. Regulation of SLBP may account for the posttranscriptional component of the cell cycle regulation of histone mRNA.
Transient behaviour of a polymer dragged through a viscoelastic medium
Creators: name: Vandebroek, Hans
name: Vanderzande, Carlo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the dynamics of a polymer that is pulled by a constant force through a viscoelastic medium. This is a model for a polymer being pulled through a cell by an external force, or for an active biopolymer moving due to a self generated force. Using a Rouse model with a memory dependent drag force, we find that the center of mass of the polymer follows a subballistic motion. We determine the time evolution of the length and the shape of the polymer. Through an analysis of the velocity of the monomers, we investigate how the tension propagates through the polymer. We discuss how polymers can be used as a probe of the properties of a viscoelastic medium.
description: 21 pages, 6 figures
Deep Neural Networks to Correct Sub-Precision Errors in CFD
Creators: name: Haridas, Akash
name: Vadlamani, Nagabhushana Rao
name: Minamoto, Yuki
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Machine Learning (cs.LG)
subject: Numerical Analysis (math.NA)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Information loss in numerical physics simulations can arise from various sources when solving discretized partial differential equations. In particular, errors related to numerical precision ("sub-precision errors") can accumulate in the quantities of interest when the simulations are performed using low-precision 16-bit floating-point arithmetic compared to an equivalent 64-bit simulation. On the other hand, low-precision computation is less resource intensive than high-precision computation. Several machine learning techniques proposed recently have been successful in correcting errors due to coarse spatial discretization. In this work, we extend these techniques to improve CFD simulations performed with low numerical precision. We quantify the precision-related errors accumulated in a Kolmogorov forced turbulence test case. Subsequently, we employ a Convolutional Neural Network together with a fully differentiable numerical solver performing 16-bit arithmetic to learn a tightly-coupled ML-CFD hybrid solver. Compared to the 16-bit solver, we demonstrate the efficacy of the hybrid solver towards improving various metrics pertaining to the statistical and pointwise accuracy of the simulation.
description: Accepted for "Applications in Energy and Combustion Science"
Tout le monde est fatigué … alors arrête de râler!
Creators: name: Jessica, Boella
name: Valeria, D'Amico
Publisher: name: Unknown
Year: 0

description: La fatigue est une réalité bien connue des patients atteints d’une maladie cancéreuse. Malheureusement, souvent sous-diagnostiquée et sous-traitée, elle reste le symptôme le plus rapporté, en terme d’impact sur la qualité de vie. De plus, ce symptôme peut se perpétuer dans le temps, pour certaines personnes en rémission clinique de leur cancer. Il s’agit, dès lors, de relever le rôle autonome de l’infirmière auprès de cette population.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo
Creators: name: Itie, A.
name: Kickhoefer, V. A.
name: Lansdorp, P. M.
name: Hande, M. P.
name: Snow, B. E.
name: Liu, Y.
name: Baerlocher, G.
name: Robinson, M. O.
name: Harrington, L.
name: Yeung, D.
name: Wakeham, A.
name: Siderovski, D. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: TEP1 is a mammalian telomerase-associated protein with similarity to the Tetrahymena telomerase protein p80. Like p80, TEP1 is associated with telomerase activity and the telomerase reverse transcriptase, and it specifically interacts with the telomerase RNA. To determine the role of mTep1 in telomerase function in vivo, we generated mouse embryonic stem (ES) cells and mice lacking mTep1. The mTep1-deficient (mTep1−/−) mice were viable and were bred for seven successive generations with no obvious phenotypic abnormalities. All murine tissues from mTep1−/− mice possessed a level of telomerase activity comparable to that in wild-type mice. In addition, analysis of several tissues that normally lack telomerase activity revealed no reactivation of telomerase activity in mTep1−/− mice. Telomere length, even in later generations of mTep1−/− mice, was equivalent to that in wild-type animals. ES cells deficient in mTep1 also showed no detectable alteration in telomerase activity or telomere length with increased passage in culture. Thus, mTep1 appears to be completely dispensable for telomerase function in vivo. Recently, TEP1 has been identified within a second ribonucleoprotein (RNP) complex, the vault particle. TEP1 can also specifically bind to a small RNA, vRNA, which is associated with the vault particle and is unrelated in sequence to mammalian telomerase RNA. These results reveal that TEP1 is an RNA binding protein that is not restricted to the telomerase complex and that TEP1 plays a redundant role in the assembly or localization of the telomerase RNP in vivo.