cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification and characterization of a heme-dedicated periplasmic binding protein in Haemophilus ducreyi
Creators: name: St. Denis, Melissa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biology, Microbiology.

description: In Haemophilus ducreyi, heme uptake likely proceeds via a receptor-mediated process. The initial event involves binding to either of two outer membrane receptors, TdhA and HgbA. Once heme is deposited into the periplasmic space, we hypothesize that a heme-dedicated periplasmic binding protein (hHBP) is responsible for transporting heme across the periplasmic space to the inner membrane. To identify the hHBP, periplasmic extracts were generated from H. ducreyi 35000 grown under high and low heme conditions and subjected to proteome mapping. Peptide sequences of upregulated proteins grown under heme-restrictive conditions were determined by mass spectroscopy. A candidate hHBP was identified as a periplasmic binding protein homologous to YfeA of Yersinia pestis. The gene encoding this protein appears to be in a typical ABC transporter operon. Under iron-limiting conditions, no upregulation of the hHBP expression was observed; however, the purified hHBP was shown to specifically bind heme in a concentration-dependent manner.
Ficedula tricolor subsp. diversa Vaurie 1953
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Ficedula
Ficedula tricolor
Ficedula tricolor diversa vaurie

description: Ficedula tricolor diversa Vaurie
 Ficedula tricolor diversa Vaurie, 1953a: 1 (Lungan, now Pingwu, Mo Tien Ling Range, on the borders of Szechwan and Kansu).
 Now Ficedula tricolor diversa Vaurie, 1953. See MacKinnon and Phillipps, 2000: 308, and del Hoyo et al., 2006: 143.
 HOLOTYPE: AMNH 605993, adult male, collected at P’ing-wu (5 Lungan), 32.25N, 104.36E (USBGN, 1968b), Sichuan, China, on 24 April 1893 (Julian calendar, converted by Vaurie to 8 May, Gregorian calendar), by Berezowski. From the Rothschild Collection.
COMMENTS: Vaurie cited the AMNH number of the holotype in the original description. He gave measurements of 37 additional specimens from China (Yunnan, Sichuan, Gansu, Shaanxi), Tonkin, and Laos. Because Vaurie borrowed specimens for this study and they were not individually identified, it is not possible to identify the paratypes.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 93, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Cyornis hyacinthina subsp. kuhni Hartert
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Cyornis
Cyornis hyacinthina
Cyornis hyacinthina kühni hartert

description: Cyornis hyacinthina kühni Hartert
 Cyornis hyacinthina kühni Hartert, 1904a: 204 (Wetter).
 Now Cyornis hyacinthinus kuehni Hartert, 1904. See White and Bruce, 1986: 359, and del Hoyo et al., 2006: 159.
 HOLOTYPE: AMNH 605473, adult male, collected on Wetar (5 Wetter) Island, 07.48S, 126.18E (White and Bruce, 1986: 491), Lesser Sunda Islands, Indonesia, on 24 September 1902, by Heinrich Kühn (no. 5467). From the Rothschild Collection.
COMMENTS: In the original description, Hartert cited Kühn’s unique field number of the holotype. The type series comprised nine males and seven females, including the holotype, all collected on Wetar in September and October 1902. Of the 15 paratypes, only 5 males and 4 females came to AMNH with the Rothschild Collection: AMNH 605474– 605482.
 Watson et al. (1986b: 359) included this species in the genus Niltava.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 93, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Results from nanoindentation, EDX, and statistical analysis. from Wear patterns of radular teeth in Loligo vulgaris (Cephalopoda; Mollusca) are related to their structure and mechanical properties
Creators: name: Hackethal, Svenja
name: Schulz-Kornas, Ellen
name: Gorb, Stanislav N.
name: Krings, Wencke
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 320203
subject: Clinical microbiology
classificationCode: 400302
subject: Biomaterials

description: Radular teeth have to cope with wear, when interacting with ingesta. In some molluscan taxa, wear-coping mechanisms, related to the incorporation of high contents of iron or silica, have been previously determined. For most species, particularly for those which possess radulae without such incorporations, wear-coping mechanisms are understudied. In the present study, we documented and characterized the wear on radular teeth in the model species Loligo vulgaris (Cephalopoda). By applying a range of methods, the elementary composition and mechanical properties of the teeth were described, to gain insight into mechanisms for coping with abrasion. It was found that the tooth regions that are prone to wear are harder and stiffer. Additionally, the surfaces interacting with the ingesta possessed a thin coating with high contents of silicon, probably reducing abrasion. The here presented data may serve as an example of systematic study of radular wear, in order to understand the relationship between the structure of radular teeth and their properties.
Cyornis vanheysti Robinson and Kloss
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Cyornis
Cyornis vanheysti

description: Cyornis vanheysti Robinson and Kloss
 Cyornis vanheysti Robinson and Kloss, 1919: 104 (Toentoengan, Deli, N.E. Sumatra).
 Now Cyornis ruecki (Oustalet, 1881). See Watson et al., 1986b: 361, Van Marle and Voous, 1988: 189, and del Hoyo et al., 2006: 149–150.
 HOLOTYPE: AMNH 450702, adult male, collected at Tuntungan (5 Toentoengan), 03.22N, 98.34E (van Marle and Voous, 1988: 217), Deli, Sumatra Island, Indonesia, on 10 February 1918, by A.F.C.A. van Heyst (no. 986). From the Rothschild Collection.
 COMMENTS: Robinson and Kloss had a type series of two specimens, with the holotype being the adult male from Tuntungan. The paratype is AMNH 450701 (van Heyst no. 229), an immature male, collected at Deli Toewa, Deli, northeast Sumatra, on 4 April 1917. In their original description, Robinson and Kloss suspected that C. vanheysti might be a synonym of C. ruecki, at that time known only from types in MNHP.
 Originally, the current name of this form was spelled Siphia ruckii, without an umlaut (Oustalet, 1881: 78), although Rück’s name was spelled with an umlaut. Watson et al. (1986b: 361), who included Cyornis in Niltava, spelled the specific name ruecki, noting an emendation by Sharpe. Most, if not all, authors publishing prior to Sibley and Monroe (1990) accepted Sharpe’s emendation as justified, and the spelling ruecki was certainly in prevailing usage. Sibley and Monroe (1990: 530) considered Sharpe’s emendation unjustified, and reverted to the original spelling. Since then, most authors have followed Sibley and Monroe: for example, Dickinson (corrigenda 2.1 for 2003: 696) and del Hoyo (2006: 149). I have not found any information on Rück’s nationality, and in accordance with the Code (ICZN, 1999: 40, Art. 32.5.2.1) have retained the umlaut.
This holotype was not listed in Hartert’s lists of types in the Rothschild Collection, but it bears a Rothschild type label.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 94, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Acid-base regulation in rainbow trout: The roles of carbonic anhydrase and cortisol
Creators: name: Collier, Christina Lee
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biology, Animal Physiology.

description: This study tests the hypotheses that compensation for metabolic acid-base disturbances involves regulation of carbonic anhydrase (CA) and that cortisol plays an important role in mediating the compensatory responses of the rainbow trout, Oncorhynchus mykiss. Metabolic acidosis decreased mRNA expression of branchial trout cytosolic CA (tCAc) and increased mRNA expression of renal tCAc and membrane-bound CAIV (tCAIV). Metabolic alkalosis increased mRNA expression of branchial and renal tCAc, decreased renal tCAIV mRNA expression, and increased branchial CA activity. Plasma cortisol was elevated during acidosis and alkalosis, indicating its possible involvement in regulating the response to an acid-base challenge. Cortisol may up-regulate CA, as treatment with exogenous cortisol increased tCAc and tCAIV mRNA expression, renal tCAc protein abundance, and branchial CA activity. This study suggests that CA contributes to the compensation of metabolic acid-base disturbances in the rainbow trout, and that cortisol is involved in the regulation of acid-base status.
TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium
Creators: name: Centeio, Raquel
name: Cabrita, Inês
name: Schreiber, Rainer
name: Kunzelmann, Karl
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: TMEM16F, exocytosis, goblet cell metaplasia, Notch signaling, TMEM16A
subject: 610 Medizin

description: Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal. Loss of airway expression of TMEM16A induced a massive expansion of the secretory cell population like goblet and club cells, causing differentiation into a secretory airway epithelium. Knockout of the Ca2+-activated Cl− channel TMEM16A or the phospholipid scramblase TMEM16F leads to mucus accumulation in intestinal goblet cells and airway secretory cells. We show that both TMEM16A and TMEM16F support exocytosis and release of exocytic vesicles, respectively. Lack of TMEM16A/F expression therefore causes inhibition of mucus secretion and leads to goblet cell metaplasia. The human basal epithelial cell line BCi-NS1.1 forms a highly differentiated mucociliated airway epithelium when grown in PneumaCult™ media under an air liquid interface. The present data suggest that mucociliary differentiation requires activation of Notch signaling, but not the function of TMEM16A. Taken together, TMEM16A/F are important for exocytosis, mucus secretion and formation of extracellular vesicles (exosomes or ectosomes) but the present data do no not support a functional role of TMEM16A/F in Notch-mediated differentiation of BCi-NS1.1 cells towards a secretory epithelium.
О НОВОМ НАПРАВЛЕНИИ ПОДГОТОВКИ ПРОВИЗОРОВ ДЛЯ РАБОТЫ В ВЕТЕРИНАРНЫХ АПТЕЧНЫХ ОРГАНИЗАЦИЯХ В ТЮМЕНСКОМ ГОСУДАРСТВЕННОМ МЕДИЦИНСКОМ УНИВЕРСИТЕТЕ
Creators: name: Кныш Ольга Ивановна
name: Бышенко Виктория Владимировна
name: Задираченко Людмила Николаевна
Publisher: name: Медицинское образование и профессиональное развитие
Year: 2019
Subjects: ветеринарная аптечная организация
лекарственные средства для ветеринарного применения
фармация
образование
учебнометодический комплекс

description: Современные тенденции развития фармацевтического образования в РФ направлены на расширение возможностей реализации будущих специалистов в различных видах деятельности. Основное направление деятельности выпускника фармацевтического факультета – сфера обращения лекарственных средств (ЛС), включающая не только обращение ЛС для медицинского применения, но и ЛС для ветеринарного применения. Неоднократно в Минздраве России обсуждали вопрос о включении в номенклатуру должностей фармацевтических специалистов должности «провизор ветеринарной аптечной организации». Базовая подготовка таких специалистов, конкретизация их специфических компетенций, разработка задач, трудовых функций и дальнейшая реализация на практике способствовали бы минимизации целого комплекса нарушений, которые в настоящее время выявляются в данных организациях в ходе контрольных мероприятий. С этой целью был разработан учебно-методический комплекс новой дисциплины «Особенности деятельности ветеринарных аптечных организаций» для подготовки студентов фармацевтического факультета к профессиональной деятельности в области обращения ЛС для ветеринарного применения.
Siphia hainana Ogilvie-Grant
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Siphia
Siphia hainana

description: Siphia hainana Ogilvie-Grant
 Siphia hainana Ogilvie-Grant, 1900d: 36 (Five-finger Mountains, in the interior of Hainan).
 Now Cyornis hainanus (Ogilvie-Grant, 1900). See MacKinnon and Phillipps, 2000: 312, and del Hoyo et al., 2006: 149.
SYNTYPES: AMNH 450764, adult male, 17 May 1899, and AMNH 450765, adult female, 14 May 1899, both collected in the Five Finger Mountains, 18.59N, 109.45E (Times Atlas), Hainan Island, China, by John Whitehead (nos. 222 and 210, respectively). From the Rothschild Collection.
COMMENTS: In his description of this species, Ogilvie-Grant did not designate a type, describing male and female but not giving the number of specimens examined. He apparently had the entire Whitehead Hainan collection before him, as the collection was sent to him at BMNH after Whitehead’s death in the field on this expedition (Ogilvie-Grant, 1900c: 461). The above specimens bear labels printed ‘‘ Mus. Brit. ’’ and filled in with Whitehead’s data, presumably while the collection was in Ogilvie-Grant’s hands; they also bear Rothschild Museum labels and are both marked ‘‘Co-type’’ by a hand unknown. They had not previously been recognized as syntypes, and AMNH type labels have been added. Two other syntypes were purchased by BMNH from the dealer E. Gerrard (Warren and Harrison, 1971: 229).
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 95, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Факторы риска манифестации сахарного диабета типа 1 у детей в регионах Поволжья
Creators: name: Корнева Ксения Георгиевна
name: Стронгин Леонид Григорьевич
name: Алмазова Арусяк Мясниковна
name: Колбасина Елена Владимировна
name: Будылина Марина Валерьевна
name: Макеева Наталья Валерьевна
name: Загайнов Владимир Евгеньевич
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: сахарный диабет типа 1
вакцина для профилактики полиомиелита
стресс

description: Сахарный диабет типа 1 (СД1) является распространенной эндокринной патологией среди детей и лиц молодого возраста. Доклиническая диагностика СД1 не разработана. Изучение факторов внешней среды, потенциально ведущих к развитию СД1 и их вклад в развитие заболевания, представляет интерес. Цель исследования – оценить роль факторов современной окружающей среды в развитии СД1 на основании анкетирования у лиц с семейной предрасположенностью в ряде регионов Поволжья и выявить категорию клинически здоровых сибсов для дальнейшего динамического наблюдения и возможного терапевтического вмешательства на доклинической стадии. Материал и методы. В анкетировании приняли участие 195 детей с СД1 и 252 их кровных братьев и сестер. Среди них 66,4% детей из Нижегородской области, 21% из Чувашской Республики, 11% из Республики Марий Эл и 1,6% из Ульяновской области. При составлении опросника были учтены потенциальные факторы риска, нашедшие отражение в современной литературе. Результаты и обсуждение. В группе детей с СД1 достоверно чаще регистрировались любые проанализированные в данной работе стрессовые ситуации. Показатель относительного риска свидетельствовал о прямой связи между перенесенными стрессами и развитием СД1 [1,41 (95% доверительный интервал (ДИ) 1,11–1,78); р<0,007]. Результаты анализа данных обязательной вакцинации, принятой в Российской Федерации, показали повышение относительного риска развития СД1 после применения вакцины для профилактики полиомиелита [1,07 (ДИ 95% 1,02–1,13); p<0,014]. Заключение. Стрессовые ситуации могут провоцировать манифестацию СД1 у генетически предрасположенных лиц. Применение вакцины против полиомиелита ассоциируется с риском развития СД1 в будущем, что требует дальнейшего изучения. Комплексное изучение влияния различных факторов внешней среды позволит выделить категорию здоровых детей с наследственной предрасположенностью к СД1, требующую дальнейшего динамического наблюдения, а также позволит определить приоритетную группу для лечебного вмешательства на доклинической и на ранней клинической стадии.
Siphia omissa Hartert 1896
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Siphia
Siphia omissa

description: Siphia omissa Hartert
 Siphia omissa Hartert, 1896c: 171 (hills of Indrulaman, about 2500 feet high, just below Bonthain Peak).
 Now Cyornis rufigastra omissus (Hartert, 1896). See White and Bruce, 1986: 360, and del Hoyo et al., 2006: 156.
LECTOTYPE: AMNH 605392, adult male, collected at Indrulaman, Sulawesi Island, Indonesia, in September 1895, by Alfred Everett. From the Rothschild Collection.
 COMMENTS: In the original description, Hartert spoke of ‘‘types’’ from Indrulaman, just below Gunung Lompobattang (5 Bonthain Peak), 05.22S, 119.58E (Times Atlas), and a pair from the lake of Tondano. Later, Hartert (1920: 491) designated as lectotype the single male specimen collected by Everett at Indrulaman in September 1895. The paralectotypes are: AMNH 605386 and 605387, unsexed, collected at Todano Lake in August to September 1892, by A.B. Meyer; AMNH 450707, male, AMNH 605393 and 605494, adult females, and AMNH 605395, immature female, all collected at Indrulaman by Everett in October 1895. Specimens collected by Doherty on Bonthain Peak in 1896 were not included in Hartert’s type series.
 Watson et al. (1986b: 372) included the species rufigastra in Niltava.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 97, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Взгляд на проблему ожирения глазами пациента и врача
Creators: name: Сергеева Виктория Алексеевна
name: Акжигитова Альбина Рафаилевна
name: Конкина Елена Александровна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: ожирение
сахарный диабет типа 2
остеоартрит
артериальное давление
артериальная гипертензия
кардиоваскулярный риск
образ жизни
дислипидемия

description: Проблема ожирения в настоящее время особенно актуальна в связи с масштабами ее распространения в России, в том числе и среди молодых людей. В нашей работе мы оценили проблемы в повседневной жизни, с которыми сталкиваются пациенты с уже имеющимися ассоциированными с ожирением заболеваниями, и молодых людей с ожирением без патологии. Проведено анонимное анкетирование пациентов с их устного согласия, проведены антропометрические измерения, определение артериального давления, частоты сердечных сокращений в покое, стратифицирован кардиоваскулярный риск. Результаты исследования выявили множество проблем с образом жизни пациентов и молодежи с ожирением, высокие кардиометаболические риски и психосоциальные трудности в повседневной жизни. Большинство респондентов стремятся к снижению массы тела на словах, при этом готовность к медикаментозной терапии ожирения достаточно низкая, что может быть связано с низкой информированностью по этому вопросу и недостаточной работой врачей в этом направлении. У пациентов с ос теоартритом и сахарным диабетом типа 2 выявлен ряд других ассоциированных с ожирением заболеваний. Среди молодых людей с ожирением у значительного числа отмечается повышение артериального давления. Таким образом, полученная информация дает представление о глубине проблемы ожирения, важности профилактического направления работы с пациентами и своевременности немедикаментозного и медикаментозного вмешательства
Qualité des données et mesure de performance des projets de développement socioéconomique :   Critique sur la convergence des critères d'évaluation de la qualité des données
Creators: name: Olivier Mumbere Muhongya
Publisher: name: Zenodo
Year: 2024

description: Les données chiffrées ou quantitatives sont celles qui rassemblent le plus de consensus parmi les parties prenantes aux projets de développement socioéconomiques. La plupart de fois les performances des projets sont exprimées en termes des données qualitatives ou quantitatives. Il est donc important sinon incontournable de réunir un consensus autour des critères de la qualité des données. Or, il est globalement décevant de constater que chaque bailleur dispose de ses pratiques en matière de critères de qualité. Il y a là le risque d’un chaos organisé qui ne saurait guère favoriser la lecture de performances, et partant de l’efficacité, des projets ou programmes individuels. Cet article s’appuie sur une revue de la littérature disponible sur google pour ressortir les critères les plus saillants et propose des critères les plus fréquents et pertinents.
Доказательная медицина, или Уроки исследования ORIGIN (Outcome Reduction with Initial Glargine INtervention)
Creators: name: Аметов Александр Сергеевич
name: Доскина Елена Валерьевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: сахарный диабет
инсулинотерапия
инсулин гларгин
доказательная медицина
ORIGIN

description: Одним из наиболее значимых и глобальных исследований последнего десятилетия является ORIGIN (Outcome Reduction with Initial Glargine INtervention – уменьшение последствий сахарного диабета путем раннего назначения инсулина гларгин) – сравнение лечения препаратом Лантус® (инсулин гларгин 100 ЕД/мл) со стандартной гипогликемической терапией в отношении времени развития первого крупного сердечно-сосудистого осложнения. Результаты, полученные в длительном исследовании, доказали эффективность инсулинотерапии (гларгин 100 ЕД/мл), его кардиои онкобезопасность.
Оценка качества гликемического контроля и управление сахарным диабетом: история, основные методы и клинические аспекты эффективного использования в реальной практике
Creators: name: Мишра Ольга Александровна
name: Невольникова Анна Олеговна
name: Тертычная Екатерина Андреевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: гликированный гемоглобин
самоконтроль глюкозы
непрерывное мониторирование уровня глюкозы
сахарный диабет

description: Эффективное управление сахарным диабетом (СД) зависит от качества оценки гликемического контроля. На сегодняшний день основные методы контроля уровня глюкозы крови включают определение гликированного гемоглобина, самоконтроль с помощью глюкометров и непрерывное мониторирование уровня глюкозы (НМГ). В работе представлены исторические аспекты, преимущества и ограничения каждого метода при клиническом применении. Гликированный гемоглобин как интегральный показатель не отражает колебаний глюкозы в течение определенного временного интервала, периодов гипои гипергликемии. Инновационные методики НМГ позволяют детально оценить колебания гликемии в течение суток и выбрать индивидуальную лечебную тактику у пациентов с СД в каждом клиническом случае. Необходимо определить показания к проведению НМГ и стандартизировать его основные параметры. Обучение и мотивация пациентов значительно повышают эффективность использования НМГ в реальной клинической практике.
Патогенетический подход к лечению автономной диабетической невропатии: место препаратов альфа-липоевой кислоты
Creators: name: Солуянова Татьяна Николаевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: патогенез
клинические особенности
антиоксидантная терапия
автономная диабетическая невропатия
сердечно-сосудистые заболевания
сахарный диабет типа 2
кардиальная невропатия
профилактика смертности

description: В статье проведен обзор данных о патогенезе, клинических особенностях и обоснованности антиоксидантной терапии при автономной диабетической невропатии. Актуальность изучения данной проблемы связана с тем, что сердечно-сосудистые заболевания (ССЗ) являются ведущей причиной заболеваемости и смертности у больных сахарным диабетом. ССЗ при сахарном диабете типа 2 диагностируются в 2–5 раз чаще, а смертность от ССЗ при сахарном диабете достигает 75% случаев. Поэтому раннее выявление сердечно-сосудистых рисков, в том числе связанных с кардиальной невропатией, является приоритетным направлением для профилактики смертности от диабетических осложнений.
Микрососудистые осложнения сахарного диабета (лекция)
Creators: name: Вербовая Нелли Ильинична
name: Долгих Юлия Александровна
name: Вербовой Андрей Феликсович
name: Галкин Рудольф Александрович
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: сахарный диабет
диабетическая ретинопатия
диабетическая нефропатия
диабетическая невропатия
синдром диабетической стопы

description: Проблема сахарного диабета (СД) существует в медицине достаточно давно, но она не теряет своей актуальности в современном мире. СД – распространенное заболевание, которое существенно снижает качество жизни и трудоспособность пациентов. В основном это происходит из-за его осложнений, которые в конечном итоге приводят к полной или частичной потере зрения, развитию почечной недостаточности и, как следствие, гемодиализу, а также к ампутациям. Статья посвящена основным аспектам патогенеза и клинических проявлений микрососудистых осложнений СД: диабетической ретинопатии, диабетической нефропатии, диабетической невропатии и синдрома диабетической стопы. Обсуждаются методы их диагностики. Также внимание уделено методам лечения указанных осложнений.
Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations
Creators: name: Jackson, Heather A
name: Accili, Eric A
Publisher: name: BioMed Central
Year: 2015

description: Background. Mutations in HERG and KCNQ1 potassium channels have been associated with Long QT syndrome and atrial fibrillation, and more recently with sudden infant death syndrome and sudden unexplained death. In other proteins, disease-associated amino acid mutations have been analyzed according to the chemical severity of the changes and the locations of the altered amino acids according to their conservation over metazoan evolution. Here, we present the first such analysis of arrhythmia-associated mutations (AAMs) in the HERG and KCNQ1 potassium channels. Results Using evolutionary analyses, AAMs in HERG and KCNQ1 were preferentially found at evolutionarily conserved sites and unevenly distributed among functionally conserved domains. Non-synonymous single nucleotide polymorphisms (nsSNPs) are under-represented at evolutionarily conserved sites in HERG, but distribute randomly in KCNQ1. AAMs are chemically more severe, according to Grantham's Scale, than changes observed in evolution and their severity correlates with the expected chemical severity of the involved codon. Expected chemical severity of a given amino acid also correlates with its relative contribution to arrhythmias. At evolutionarily variable sites, the chemical severity of the changes is also correlated with the expected chemical severity of the involved codon. Conclusion Unlike nsSNPs, AAMs preferentially locate to evolutionarily conserved, and functionally important, sites and regions within HERG and KCNQ1, and are chemically more severe than changes which occur in evolution. Expected chemical severity may contribute to the overrepresentation of certain residues in AAMs, as well as to evolutionary change.
Vulnerability of buildings to blast loads and progressive collapse
Creators: name: Yagob, Omer Salem Ahmed
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Civil.

description: This study is intended to contribute to the understanding of the behaviour of buildings when subjected to blast loads, and to assess the potential for progressive collapse when columns are lost or severely damaged due to blasts. The objective of the study is twofold, i.e., (i) to investigate the performance of reinforced concrete frame buildings subjected to blast loads, and (ii) to assess the vulnerability of such buildings to progressive collapse. Two buildings designed for Ottawa in accordance with the 2005 edition of the National Building Code of Canada were used to achieve these objectives. One of the buildings was designed as a moderately ductile, and the other one as a ductile frame building. For the purpose of the first objective, nonlinear time history analyses were conducted to the moderately ductile building for a number of bomb blast scenarios. Blast loads resulting from detonations of 125 kg, 250 kg, and 500 kg TNT at distances of 5, 10, 15, 20, 25 and 30 m from the building were used in the analysis. The performance of the building was assessed by considering the interstorey drifts, displacement ductilities, and curvature ductilities obtained from the analysis. The results from the analyses showed that the building could be severely damaged and even could collapse when subjected to blast loads due to bomb detonations at distances smaller than 15 m from the building. Regarding the second objective, both the moderately ductile and the ductile buildings were analysed following the guidelines for progressive collapse analysis and design, prepared by the U.S. General Services Administration (GSA). Columns were removed at the first storey of each building. The following three cases were considered: (i) exterior column removed, (ii) corner column removed, and (iii) interior column removed. Elastic static analysis was conducted for each of these cases using 3-D models, and applying loads as required by the GSA guidelines. The demand/capacity ratios obtained from the analysis, and the GSA criteria were used for the assessment of the vulnerability to progressive collapse. The results showed that the ductile building is much more vulnerable to progressive collapse than the moderately ductile building.
Комбинированная терапия на старте сахарного диабета типа 2 – время действовать
Creators: name: Кондратьева Лариса Васильевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: сахарный диабет типа 2
сахароснижающая терапия
комбинированная терапия
фиксированная комбинация метформина и ингибитора ДПП-4

description: Распространенность и численность пациентов с сахарным диабетом неуклонно увеличивается во всем мире. Основной контингент составляют больные сахарным диабетом типа 2, многие из них уже при установлении диагноза имеют осложнения и коморбидные состояния. К приоритетным задачам современной медицины относятся стратегия и определение тактики лечения пациентов с сахарным диабетом типа 2.
BRONCHIECTASIS IN CHILDREN: REVIEW OF CURRENT CLINICAL GUIDELINES
Creators: name: Isakov, Abdurauf
Publisher: name: Zenodo
Year: 2024

description: the article is devoted to the problem of bronchiectasis in pediatric patients and reflects the most current approaches to the diagnosis and management of patients with this pathology. Information about the true prevalence of bronchiectasis both abroad and in Uzbekistan varies. At the same time, bronchiectasis can be either an independent disease or a manifestation of another pathology, which necessitates the need for an integrated multidisciplinary approach not only for diagnosis, but also in the management of patients with this pathology.
Микроваскулярная стенокардия и сахарный диабет: что важно не упустить
Creators: name: Бугова Лариса Абубакировна
name: Табаксоева Жамиля А-Керимовна
name: Курданова Марьям Хусейновна
name: Урусбиева Джаннета Магометовна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2019
Subjects: клинический случай
микроваскулярная стенокардия
сахарный диабет
бронхиальная астма

description: Описан клинический случай выявления микроваскулярной стенокардии (кардиального синдрома X) у пациентки с сахарным диабетом типа 2 и бронхиальной астмой.
ТАҚИҚЛАНГАН ЭКИНЛАРНИ ЕТИШТИРИШ ЖИНОЯТИДА ИСБОТЛАНИШИ ЛОЗИМ БЎЛГАН ҲОЛАТЛАР
Creators: name: Хайруллаев, А.
Publisher: name: Zenodo
Year: 2024

description: мазкур мақолада бугунги кунда тақиқланган экинларни етиштириш жиноятлари бўйича исботланиши лозим бўлган ҳолатлар, мазкур турдаги жиноят ишларини тергов қилиш давомида эътиборга олиниши лозим бўлган жиҳатлар, бу турдаги ишлар бўйича тайинланадиган экспертизалар ва амалиётда вужудга келаётган муаммолар, уларнинг ечимлари бўйича илмий-амалий таклиф ва мулоҳазалар ёритилган.
Cystic Fibrosis Target Product Profiles: Focus group documents (topic guides and participant information sheets)
Creators: name: Howe, Nicola
name: Green, Kile
name: Naseem, Raasti
Publisher: name: Newcastle University
Year: 2024
Subjects: classificationCode: 320602
subject: Medical biotechnology diagnostics (incl. biosensors)
classificationCode: 320203
subject: Clinical microbiology

description: Diagnostics are key to the appropriate detection, treatment and management of many conditions and associated health implications. People with cystic fibrosis are susceptible to recurrent pulmonary infections that over time contribute to deterioration and degeneration of the lung. Launched in 2019, the Cystic Fibrosis (CF) Antimicrobial Resistance (AMR) Syndicate was formed to accelerate the translation and adoption of new CF antimicrobials and diagnostics to the clinic through collaboration (https://cfamr.org.uk/), bringing better treatment options to people with CF, faster.
To catalyse the development of new diagnostics, the CF AMR Syndicate, together with the Newcastle NIHR HealthTech Research Centre (formerly Newcastle NIHR MIC), has worked with the wider community to understand the unmet diagnostic needs and develop a suite of Target Product Profiles (TPPs) for CF lung infection diagnostics. The intention of this is to drive diagnostic discovery, focusing efforts where they are needed the most. Although developed in the UK with input from UK based experts and people with CF, we intend for the impact of these TPPs to be global.
This project involved three main phases, sandwiched between planning and management activities, and a dissemination strategy programme, all guided by an expert advisory group.
Phase 1 involved a landscape analysis to identify and prioritise unmet diagnostic needs via multiple focus groups of clinical experts and people with Cystic Fibrosis (pwCF), as well as a scoping review of the diagnostic space and available diagnostic tests (https://doi.org/10.1016/j.resinv.2024.07.005).
Phase 2 involved drafting the TPPs using existing literature and regulatory documentation, focus groups, one-to-one interviews with key opinion leaders (KoLs), and a web-based survey, to define ‘minimal’ and ‘optimal’ characteristics for each TPP.
Phase 3 refined and validated the TPP content through additional interviews, a two-round modified Delphi exercise, and a virtual symposium.
The final TPP documents (and a report from the virtual symposium) are available at: https://cfamr.org.uk/therapeutic-tpp/.
Cyornis banyumas subsp. peromissa Hartert
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Cyornis
Cyornis banyumas
Cyornis banyumas peromissa hartert

description: Cyornis banyumas peromissa Hartert
 Cyornis banyumas peromissa Hartert, 1920: 491 (Selayer, south of Celebes).
 Now Cyornis rufigastra peromissus Hartert, 1920. See White and Bruce, 1986: 360, and del Hoyo et al., 2006: 156.
 LECTOTYPE: AMNH 605396, adult male, collected on Salayar (5 Selayar) Island, 06.05S, 120.30E (White and Bruce, 1986: 491), south of Sulawesi Island, Indonesia, in November 1895, by Alfred Everett. From the Rothschild Collection.
 COMMENTS: Hartert (1920: 491) described peromissa within his list of types in the Rothschild Collection and designated as type a male specimen collected on Salayar Island by Everett in November 1895. There are three such specimens, but AMNH 605396 bears a Rothschild type label and the Rothschild Collection label is noted ‘‘type of peromissa’’ in Hartert’s hand. It was cataloged as the type when the Rothschild Collection came to AMNH. Because this specimen was intended as the type by Hartert and has been so considered in the literature since its description, I hereby designate AMNH 605396 the lectotype of Cyornis banyumas peromissa in order to avoid misinterpretation when refering to the older literature. Paralectotypes are: AMNH 605397 and 605398, males, and AMNH 605399, female, all collected on Salayar Island by Everett in November 1895.
 Watson et al. (1986b: 372) included the species rufigastra in Niltava.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on pages 97-98, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
L'espacetemps dans "Nikolski": Une écriture de l'identité
Creators: name: Cousineau, Geneviève
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Literature, Modern.
subject: Literature, Canadian (French).

description: Nikolski, le premier roman de Nicolas Dickner, paru en 2005, a remporte trois prestigieux prix littéraires (le Prix Anne-Hébert, le Prix des libraires du Québec et le Prix des collégiens), a déjà été publié en France chez Denoel et s'apprête à conquérir le marche international anglophone des le printemps prochain. Le roman a notamment séduit le public grâce à son écriture directe, imagée et teintée d'ironie. Nikolski s'inscrit dans une problématique actuelle, soit celle de l'identité, à laquelle nous nous intéressons particulièrement. L'objectif de notre thèse est de montrer: (1) l'originalité du traitement spatio-temporel et (2) comment l'espace et le temps influencent la formation identitaire des trois personnages principaux du roman, le narrateur-personnage, Noah et Joyce. Notre méthodologie s'appuiera sur la pragmatique, une approche qui aborde le discours comme prises de paroles ancrées dans un lieu et un temps déterminés.
Meeting report : atmospheric pollution and human reproduction
Creators: name: Slama, Rémy
name: Darrow, Lyndsey
name: Parker, Jennifer
name: Woodruff, Tracey J.
name: Strickland, Matthew
name: Nieuwenhuijsen, Mark
name: Glinianaia, Svetlana
name: Hoggatt, Katherine J.
name: Kannan, Srimathi
name: Hurley, Fintan
name: Kalinka, Jaroslaw
name: Sˇ Rám, Radim
name: Brauer, Michael (Of University Of British Columbia)
name: Wilhelm, Michelle
name: Heinrich, Joachim
name: Ritz, Beate
Publisher: name: The University of British Columbia
Year: 2015

description: BACKGROUND: There is a growing body of epidemiologic literature reporting associations between atmospheric pollutants and reproductive outcomes, particularly birth weight and gestational duration. OBJECTIVES: The objectives of our international workshop were to discuss the current evidence, to identify the strengths and weaknesses of published epidemiologic studies, and to suggest future directions for research. DISCUSSION: Participants identified promising exposure assessment tools, including exposure models with fine spatial and temporal resolution that take into account time–activity patterns. More knowledge on factors correlated with exposure to air pollution, such as other environmental pollutants with similar temporal variations, and assessment of nutritional factors possibly influencing birth outcomes would help evaluate importance of residual confounding. Participants proposed a list of points to report in future publications on this topic to facilitate research syntheses. Nested case–control studies analyzed using two-phase statistical techniques and development of cohorts with extensive information on pregnancy behaviors and biological samples are promising study designs. Issues related to the identification of critical exposure windows and potential biological mechanisms through which air pollutants may lead to intrauterine growth restriction and premature birth were reviewed. CONCLUSIONS: To make progress, this research field needs input from toxicology, exposure assessment, and clinical research, especially to aid in the identification and exposure assessment of feto-toxic agents in ambient air, in the development of early markers of adverse reproductive outcomes, and of relevant biological pathways. In particular, additional research using animal models would help better delineate the biological mechanisms underpinning the associations reported in human studies.
Vierzig Jahre „Formosa“-Zwischenfall
Creators: name: Diefenbach, Thilo
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Wie jedes Land absolviert auch Taiwan alljährlich seinen Reigen an politischen Feier- und Gedenktagen, wobei manche dieser Jubiläen, die teilweise offizielle Feiertage sind, mit Taiwan entweder ursprünglich gar nichts zu tun haben (so etwa der 10. Oktober – Gründungstag der Republik China, und zwar im Jahre 1911, als Taiwan zu Japan gehörte) oder in der Bevölkerung überwiegend negative Erinnerungen wecken (wie etwa der 25. Oktober, also der Tag, an dem 1945 die unfreundliche Übernahme Taiwans durch die Republik China erfolgte). Etwas besser sieht es schon mit dem 28. Februar aus, der zwar an ein sehr trauriges Ereignis erinnert, nämlich an die blutige Unterdrückung von Demonstrationen im März 1947, aber dennoch heute von großen Teilen der Bevölkerung aktiv begangen wird – und zwar um anzumahnen, dass Taiwan nie wieder kolonisiert werden darf, von wem auch immer. Ende dieses Jahres aber steht ein besonderes Gedenken an, nämlich der 40. Jahrestag des sogenannten „Formosa“-Zwischenfalls 美麗島事件(im englischen Sprachraum eher als „Kaohsiung-Zwischenfall“ bezeichnet). Das Wort „Formosa 美麗島“ bezieht sich in diesem Fall nicht einfach nur – wie sonst üblich – auf die Insel Taiwan, sondern auf die gleichnamige Zeitschrift. Einer der Gründer dieser Zeitschrift und eines ihrer wichtigsten Redaktionsmitglieder war Yao Chia-wen 姚嘉文, den ich zunächst kurz vorstellen möchte.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 152/153 (2019): ASIEN (Juli/Oktober)
Intentional Ambiguity in Chinese Policymaking
Creators: name: Gohli, Hannes
name: Fischer, Doris
Publisher: name: Asien
Year: 2021

description: ‘Intentional ambiguity’ is a concept that most commonly appears either in the realm of diplomacy (Benson and Niou 2001) or in military jargon to describe a situation where two factions circumvent confrontation by using imprecisions to discuss a sensitive topic upon which each side possesses contrasting ideas (Johnson 2017). While much criticism is directed at China using the strategy in its dealings with foreign nations, little attention has been paid to analysing how that country’s government uses purposefully ill-defined policies to stimulate economic and technological development at home (Ahrens 2013). This article seeks to remedy this analytical deficiency by outlining in detail the theory of ‘strategic ambiguity’, and extending deliberations thereon to the case of the Chinese ‘smart grid’. The study will reveal how vague understanding of smart grids in the literature and in industry, coupled with intentionally hazy policy prescriptions from central government institutions, while stimulating technological innovation and local policy experimentation are also misleading investors in the electricity market and creating favourable conditions for large state-owned enterprises at the expense of their privately-owned small and medium-sized counterparts.∗
description: Asien, Nr. 152/153 (2019): ASIEN (Juli/Oktober)
Siphia djampeana Hartert
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Muscicapidae
Siphia
Siphia djampeana

description: Siphia djampeana Hartert
 Siphia djampeana Hartert, 1896c: 172 (Djampea).
 Now Cyornis rufigastra djampeanus (Hartert, 1896). See White and Bruce, 1986: 360, and del Hoyo et al., 2006: 156.
 LECTOTYPE: AMNH 605400, adult male, collected on Tanahjampea (5 Djampea) Island, 07.05S, 120.42E (White and Bruce, 1986: 491), Lesser Sunda Islands, Indonesia, in December 1895, by Alfred Everett. From the Rothschild Collection.
 COMMENTS: In the original description, Hartert did not designate a type, saying only that he had a ‘‘good series’’. Hartert (1920: 491) listed as lectotype a male collected on Djampea by Everett in December 1895. There are six such specimens that came to AMNH with the Rothschild collection; however, AMNH 605400 is the specimen bearing the Rothschild type label, written by Hartert, and Everett’s label is also marked ‘‘Type’’. Because it was Hartert’s intent that this specimen be the type, I hereby designate AMNH 605400 the lectotype of Siphia djampeana to avoid confusion in interpreting the older literature and to remove any ambiguity surrounding the type. The eight paralectotypes are: AMNH 605401–605404, adult males, AMNH 605405, immature male, AMNH 605406–605408, females, all collected on Tanahjampea by Everett in December 1895.
 Watson et al. (1986b: 372) included the species rufigastra in Niltava.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 98, DOI: 10.1206/313.1, http://zenodo.org/record/13223808