cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of gut hormone physiology in the regulation of appetite
Creators: name: Zac-Varghese, Sagen Elizabeth Kanissaril
Publisher: name: Imperial College London
Year: 2011

description: Peptide tyrosine tyrosine (PYY) and glucagon like peptide-1 (GLP-1) are endogenous, anorectic gut hormones released from entero-endocrine L cells. The aims of this thesis were to: investigate the breakdown of PYY using peptide analogues in vitro and in vivo, determine the stimuli for release of PYY and GLP-1 from L cells in vitro and finally to attempt to stimulate the endogenous secretion of PYY and GLP-1 and so suppress appetite in man. The breakdown of PYY was studied using specially designed PYY analogues with changes to known enzyme cleavage sites. Degradation of the analogues was studied by incubation with proteolytic enzymes. Receptor binding assays were carried out to confirm that changes to the PYY structure had not altered binding to the endogenous PYY receptors. In vivo studies in rodents previously confirmed an extended pharmacological profile of these analogues. In order to study the various stimulants for PYY and GLP-1 release, a primary L cell model was developed. This was used to study the effect of various nutrients: glucose, amino acids and short chain fatty acids (SCFA) on PYY and GLP-1 release. In mouse and human primary L cell cultures the SCFA propionate increased PYY release significantly compared to basal levels, indicating that propionate is a potent stimulus of PYY release. To further investigate the results of the in vitro work, a randomised, double blind, crossover study was carried out in human volunteers to evaluate the effect of propionate on appetite. Administration of propionate ester over six days reduced energy intake at a buffet meal by 18.8% compared to control (P < 0.05, n = 20). However, there was no significant change in plasma GLP-1 or PYY levels between the groups, possibly suggesting an alternative explanation for the reduction in appetite seen. This may provide an interesting avenue for future studies. These studies of the physiological mechanisms underlying release and degradation of PYY and GLP-1 may contribute towards the development of an anti-obesity therapy based around L cell stimulation.
Intensive monitoring of the strongly variable BL Lac S5 0716+714
Creators: name: Otterbein, K.
name: Hardcastle, M. J.
name: Wagner, S. J.
name: Worrall, D. M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The BL Lac object S5 0716+714 was monitored during a multifrequency campaign in 1996. Preliminary analysis of the optical, ROSAT and RXTE data are presented. Strong variability on short time scales was observed. The data suggest an interpretation within a multi-component model.
description: To appear in The Active X-ray Sky: Results from BeppoSAX and Rossi-XTE, Rome, Italy, 21-24 October, 1997. Eds.: L. Scarsi, Bradt, P. Giommi and F. Fiore. PS-file avialable at http://www.lsw.uni-heidelberg.de/projects/extragalactic/bl_lac.html
Elastic Functional Principal Component Regression
Creators: name: Tucker, J. Derek
name: Lewis, John
name: Srivastava, Anuj
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: We study regression using functional predictors in situations where these functions contain both phase and amplitude variability. In other words, the functions are misaligned due to errors in time measurements, and these errors can significantly degrade both model estimation and prediction performance. The current techniques either ignore the phase variability, or handle it via pre-processing, i.e., use an off-the-shelf technique for functional alignment and phase removal. We develop a functional principal component regression model which has comprehensive approach in handling phase and amplitude variability. The model utilizes a mathematical representation of the data known as the square-root slope function. These functions preserve the $\mathbf{L}^2$ norm under warping and are ideally suited for simultaneous estimation of regression and warping parameters. Using both simulated and real-world data sets, we demonstrate our approach and evaluate its prediction performance relative to current models. In addition, we propose an extension to functional logistic and multinomial logistic regression
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0008
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: cartulaire
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0008, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0008, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Entropy and String Black Hole Correspondence
Creators: name: Khuri, Ramzi R.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We make some observations regarding string/black hole correspondence with a view to understanding the nature of the quantum degrees of freedom of a black hole in string theory. In particular, we compare entropy change in analogous string and black hole processes in order to support the interpretation of the area law entropy as arising from stringy constituents.
description: 14 pages, harvmac
An Odyssey with complexity and network science: From the brain to social organisation
Creators: name: Expert, Paul
Publisher: name: Imperial College London
Year: 2011

description: Complexity science is the study of systems that give rise to a priori unexpected macroscopic patterns, at different scales, emerging from the simple microscopic rules governing the evolution of the system. Method to explore complex systems are based on tools from a wide range of sciences, including statistical mechanics. Recently, the study of the emerging properties of complex systems has been enriched by a new toolbox derived by an extension of graph theory, namely, complex network science. We use both approaches to investigate two complex systems, the human brain and the communications patterns of a social network. The brain could be considered as an archetypical complex system; its fundamental constituting units, the neurones, communicate via simple inhibitory and excitatory interactions. These give rise to an extraordinarily rich hierarchical complex system, the human mind, that enables one to apprehend and interact with the universe. Understanding how the brain functions is essential, both for the general knowledge of humanity, but also for medical purposes; a better understanding of brain functions could lead to finding cures. We investigate the dynamics of brain activity at the smallest scale accessible by functional Magnetic Resonance Imaging, the voxel, while subjects are at the resting-state. We apply real-space renormalisation from the statistical mechanics toolbox, and our findings confirm that brain dynamics displays characteristic signatures of a critical system. At a coarser level, we study the structural differences in the functional networks of a healthy cohort and one made of people at-risk of developing a mental disorder during a verbal fluency task. We find that a key brain region plays a different role in the network organisation of the two populations, which is in agreement with previous findings on the disease schizophrenia. Finally, we investigate community structure in complex systems. Social interactions in humans are also a prime example of a system with emerging structure, the nature of which is dependent on the types of interactions between individuals. We use and develop new methods for community detection to uncover structures due to spatial and linguistic interactions in a mobile phone network.
Flows and dynamos in a model of stellar radiative zones
Creators: name: Simitev, Radostin D.
name: Busse, Friedrich H.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Stellar radiative zones are typically assumed to be motionless in standard models of stellar structure but there is sound theoretical and observational evidence that this cannot be the case. We investigate by direct numerical simulations a three-dimensional and time-dependent model of stellar radiation zones consisting of an electrically-conductive and stably-stratified anelastic fluid confined to a rotating spherical shell and driven by a baroclinic torque. As the baroclinic driving is gradually increased a sequence of transitions from an axisymmetric and equatorially-symmetric time-independent flow to flows with a strong poloidal component and lesser symmetry are found. It is shown that all flow regimes characterised with significant non-axisymmetric components are capable of generating self-sustained magnetic field. As the value of the Prandtl number is decreased and the value of the Ekman number is decreased flows become strongly time-dependent with progressively complex spatial structure and dynamos can be generated at lower values of the magnetic Prandtl number.
description: Accepted for publication in the Journal of Plasma Physics on 2018-05-23. arXiv admin note: text overlap with arXiv:1707.08846
Additional file 20: of Deep proteomic network analysis of Alzheimerâ s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
Creators: name: Johnson, Erik
name: Dammer, Eric
name: Duong, Duc
name: Luming Yin
name: Thambisetty, Madhav
name: Troncoso, Juan
name: Lah, James
name: Levey, Allan
name: Seyfried, Nicholas
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Figure S13. GO Analysis of Alternative Exon-Exon Junction Peptides Unique to the RNAseq Database. Alternative exon-exon junction (alt-EEjxn) peptides that were identified by LFQ-trypsin or TMT-LysC approaches from the RNAseq data only were analyzed by gene ontology (GO), which showed that the alternatively spliced proteins identified by the two approaches in the RNAseq data were largely unique. (PDF 660Â kb)
Flexible Aircraft Dynamics with a Geometrically-Nonlinear Description of the Unsteady Aerodynamics
Creators: name: Murua, Joseba
Publisher: name: Imperial College London
Year: 2012

description: The Unsteady Vortex-Lattice Method provides a medium-fidelity tool for the prediction of non-stationary aerodynamic loads in low-speed, but high-Reynolds-number, attached flow. Despite a proven track record in applications where free-wake modelling is critical, other models based on potential-flow theory, such as the Doublet Lattice and thin-aerofoil approximation, have been favoured in fixed-wing aircraft aeroelasticity and flight dynamics. This dissertation presents how the Unsteady Vortex-Lattice Method can be re-engineered as an enhanced alternative to those techniques for diverse situations that arise in flexible-aircraft dynamics. A historical review of the methodology is included, with latest developments and practical applications. Different formulations of the aerodynamic equations are outlined, and they are integrated with a nonlinear beam model for the full description of the dynamics of a free-flying flexible vehicle, which furnishes a geometrically-nonlinear description of both structure and aerodynamics. Nonlinear time-marching captures large wing excursions and wake roll-up, and the linearisation of the equations lends itself to a seamless, monolithic state-space assembly, particularly convenient for stability analysis. The aerodynamic model and the unified framework for the simulation of high-aspect-ratio planes are exhaustively verified by comparing them to lower- and higher-fidelity approaches. Numerical studies emphasising scenarios where the Unsteady Vortex-Lattice Method can provide an advantage over other state-of-the-art tools are presented. Examples of this comprise unsteady aerodynamics in vehicles with coupled aeroelasticity and flight dynamics, and in lifting surfaces undergoing complex kinematics, large deformations, or in-plane motions. Geometric nonlinearities are shown to play an instrumental, and often counter-intuitive, role in the aircraft dynamics. The Unsteady Vortex-Lattice Method is unveiled as a remarkable tool that can successfully incorporate them in the unsteady aerodynamics modelling.
Further investigation of changes in cometary rotation
Creators: name: Mueller, Beatrice E. A.
name: Samarasinha, Nalin H.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Samarasinha & Mueller (2013) related changes of cometary rotation to other physical parameters for four Jupiter family comets defining a parameter $X$, which is approximately constant within a factor of two irrespective of the active fraction of a comet. Two additional comets are added to this sample in this paper and the claim of a nearly constant parameter $X$ for these six comets is confirmed, albeit with a larger scatter. Taking the geometric mean of $X$ for all the comets above excluding 2P/Encke (as $X$ for each comet was determined with respect to that of 2P/Encke), the expected changes in the rotation periods for a sample of 24 periodic comets are derived. We identify comets from this sample that are most likely to show observationally detectable changes in their rotation periods. Using this sample and including the six comets used to determine $X$, we find a correlation between the parameter $ζ$ (i.e. the total water production per unit surface area per orbit approximated by that inside of 4 au) and the perihelion distance $q$; specifically we derive $ζ$ $\propto$ $q^{-0.8}$ and provide a theoretical basis for this in Appendix A. This relationship between $ζ$ and $q$ enables ready comparisons of activity due to insolation between comets. Additionally, a relationship between the nuclear radius $R$ and the rotation period $P$ is found. Specifically, we find that on average smaller nuclei have smaller rotation periods compared to the rotation periods of larger nuclei. This is consistent with expectations for rotational evolution and spin-up of comet nuclei, providing strong observational evidence for sublimation-driven rotational changes in comets.
description: 13 pages, 3 tables, 4 figures. Accepted by AJ
Modelling of Silicon-Germanium Alloy Heterostructures using Double Group Formulation of k . p theory
Creators: name: Ward, Robert M.
Publisher: name: Imperial College London
Year: 2012

description: Silicon-Germanium alloy heterostructures offer the most viable opportunity to integrate electronics with optoelectronic devices for widespread commercial application. Indeed Germanium rich devices may be designed for application around 1.5 m by preying on the direct-gap energy of 890meV. Low power optical modulators operating, under the quantum confined Stark effect, at wavelength bands used in 3rd generation fibre optic communication channels are developed in this thesis from a theoretical perspective. An investigation into strained Germanium rich quantum well structures was performed, revealing information about sub-band dispersion, joint density of states and absorption coefficient using the double group formulation of k . p theory. Using zone centre eigenstates as symmetrised half integer basis functions transforming according to irreps of the double group, the spin orbit interaction is incorporated into the unperturbed Hamiltonian. Along with semi-empirical input parameters available in the literature, dispersion in bulk Silicon and Germanium reveals information about hole effective masses and indirect conduction band minima in broad agreement with experimental data. In accordance with degenerate perturbation theory; effective mass Hamiltonians, with an arbitrary quantisation axis through a canonical transformation, are constructed through a series of matrix multiplications. Retaining operator ordering allows numerical modelling of heterostructures grown on arbitrary growth planes with appropriate boundary conditions across an abrupt interface under the envelope function framework. In this thesis, the effect on the transition energy, hh1-e1, by the choice of growth plane in a quantum well heterostructure is investigated.
Adsorption of flexible polymer chains on a surface: Effects of different solvent conditions
Creators: name: Martins, P. H. L.
name: Plascak, J. A.
name: Bachmann, M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Polymer chains undergoing a continuous adsorption-desorption transition are studied through extensive computer simulations. A three-dimensional self-avoiding walk lattice model of a polymer chain grafted onto a surface has been treated for different solvent conditions. We have used an advanced contact-density chain-growth algorithm, in which the density of contacts can be directly obtained. From this quantity, the order parameter and its fourth-order Binder cumulant are computed, as well as the corresponding critical exponents and the adsorption-desorption transition temperature. As the number of configurations with a given number of surface contacts and monomer-monomer contacts is independent of the temperature and solvent conditions, it can be easily applied to get results for different solvent parameter values without the need of any extra simulations. In analogy to continuous magnetic phase transitions, finite-size-scaling methods have been employed. Quite good results for the critical properties and phase diagram of very long single polymer chains have been obtained by properly taking into account the effects of corrections to scaling. The study covers all solvent effects, going from the limit of {\it super-self-avoiding walks}, characterized by effective monomer-monomer repulsion, to poor solvent conditions that enable the formation of compact polymer structures.
description: 10 pages, 11 figures. arXiv admin note: text overlap with arXiv:1705.02645
Practical scheme of reduction to gauge invariant variables
Creators: name: Chechelashvili, G.
name: Jorjadze, G.
name: Kiknadze, N.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: For systems with first class constraints the reduction scheme to the gauge invariant variables is considered. The method is based on the analysis of restricted 1-forms in gauge invariant variables. This scheme is applied to the models of electrodynamics and Yang-Mills theory. For the finite dimensional model with $SU(2)$ gauge group of symmetry the possible mechanism of confinement is obtained.
description: 14 pages, Latex, no figures
Measuring the Utility of Surveillance Data For Monitoring the HIV/AIDS Epidemic In Sub-Saharan Africa
Creators: name: Marsh, Kimberly
Publisher: name: Imperial College London
Year: 2011

description: Since the early 1980s in sub-Saharan Africa (SSA), substantial human and financial resources have been dedicated to monitoring the HIV/AIDS epidemic. Throughout, surveillance data collected at antenatal care (ANC) clinics have been a key data source. ANC surveillance data are well-known to be biased when quantifying population HIV prevalence levels in SSA. Nonetheless, a routinely-accepted, although rarely-tested assumption has been that the data are representative of population-level HIV prevalence trends. More recently, HIV testing data from prevention of mother-to-child transmission (PMTCT) programmes have been proposed as a substitute for ANC surveillance, although these data can be subject to temporal biases too. The primary objective of this thesis is to add to the limited evidence regarding the representativeness of HIV testing data from pregnant women to monitor population-level HIV prevalence trends. Empirical analyses from repeated household-based population surveys and ANC surveillance were done for seven countries in SSA from 2000 to 2010 and among youth aged 15 to 24 years in Manicaland, Zimbabwe from 1985 to 2003. Also, a mathematical model was used to explore temporal bias in ANC surveillance trends in epidemics similar to those in Botswana, Côte d’Ivoire and rural Zimbabwe from 1985 to 2030. Finally, PMTCT programme data were assessed for their representativeness as compared to ANC surveillance data in Manicaland, Zimbabwe from 2006 to 2008. Results showed the representativeness of ANC surveillance data to vary by time period and setting, although trends among youth were more robust than those among adults aged 15 to 49 years across settings, and particularly so among men. Representativeness in the ART-era depends on coverage and scale-up, the setting, and the potential for changing fertility patterns among ART users. PMTCT data for surveillance purposes was of limited use in Manicaland, Zimbabwe from 2006 to 2008. In summary, caution is needed when using HIV testing data from pregnant women to monitor population HIV prevalence trends in SSA.
Slow Cooling in Low Metallicity Clouds: An Origin of Globular Cluster Bimodality?
Creators: name: Fernandez, Ricardo
name: Bryan, Greg L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We explore the relative role of small-scale fragmentation and global collapse in low-metallicity clouds, pointing out that in such clouds the cooling time may be longer than the dynamical time, allowing the cloud to collapse globally before it can fragment. This, we suggest, may help to explain the formation of the low-metallicity globular cluster population, since such dense stellar systems need a large amount of gas to be collected in a small region (without significant feedback during the collapse). To explore this further, we carry out numerical simulations of low-metallicity Bonner-Ebert stable gas clouds, demonstrating that there exists a critical metallicity (between 0.001 and 0.01 $Z_\odot$) below which the cloud collapses globally without fragmentation. We also run simulations including a background radiative heating source, showing that this can also produce clouds that do not fragment, and that the critical metallicity -- which can exceed the no-radiation case -- increases with the heating rate.
description: 12 pages, 9 figures, MNRAS in press
Towards next generation ultrasonic imaging
Creators: name: Hutt, Timothy David
Publisher: name: Imperial College London
Year: 2011

description: Recently the use of ultrasonic arrays for imaging defects in metal components has become economically attractive in Non-Destructive Testing. Given a certain array, the image quality strongly depends on how the measurements are process into an image. The current state-of-the-art imaging algorithm in actual use is delay-and-sum beamforming, which has a resolution capability that is fundamentally limited by the physical approximation used to describe how waves interact with matter. This thesis explores the practical use of alternative non-linear “super-resolution” imaging algorithms that use more accurate physical models, and can theoretically achieve unlimited resolution. This is made possible by utilising additional sources of information contained within the measurements, in particular the small amplitude multiply scattered signals. The distribution of information contained in the measurements, and utilised by the imaging algorithms is studied in the context of information capacity of signals. We discover some insights into the limits of imaging which depend on the signal-to-noise ratio. The accuracy of non-linear imaging algorithms can be strongly dependent on the accuracy of the measurements. Therefore several experiments are performed to assess their performance in practice. The experimental implementation of these methods poses a number of challenges, including removal of the incident field, and compensating for array element directivity. Super-resolution capability is demonstrated in a highly attenuative medium for the first time. To further improve the image quality we explore the possibility of using mirror reflections. This gives an increase in the effective aperture. We perform simulated and experimental reconstructions of a complex scatterer and find that the completeness of the image is improved. The mirror interface also allows quantitative speed-of-sound imaging of penetrable scatterers using the HARBUT algorithm. This is tested experimentally for the first time.
Additional file 1: of Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
Creators: name: Johnson, Erik
name: Dammer, Eric
name: Duong, Duc
name: Luming Yin
name: Thambisetty, Madhav
name: Troncoso, Juan
name: Lah, James
name: Levey, Allan
name: Seyfried, Nicholas
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Table S1. Sample List. AD, Alzheimer’s disease; AS, asymptomatic Alzheimer’s disease; CT, control; MCI, mild cognitive impairment; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease amyloid-β plaque load score; Braak, Braak stage for tau tangle burden; PMI, post-mortem interval; ApoE, apolipoprotein E isoform genotype; MMSE, Mini-Mental State Examination; NA, not available. MCI cases were not used in the final analysis. (DOCX 45 kb)
Macaca fascicularis
Creators: name: Cook-Price, Dawn R.
name: Petko, Olga N.
name: Makchai, Sunchai
name: Artchawakom, Taksin
name: Suwanwaree, Pongthep
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Primates
Cercopithecidae
Macaca
Macaca fascicularis

description: Macaca fascicularis (Raffles, 1821)
Fig. 13 A Long-tailed macaque
Notes.
Macaca fascicularis was the most observed species detected via all detection methods, with 41 individuals (Table 2) were observed on foot surveys and multiple camera traps throughout both national park forest areas (6 different transects or camera sites) and human-disturbed forest areas (6 different transects or camera sites) on the island. There is one small troop that can be seen in the southeast area of the island; however, this troop stays near the road and residential areas as humans intentionally leave food items. This lone troop behaves differently than the other troops. The wild troops encountered were very well hidden in the forest areas away from human settlement areas and throughout the island (Fig. 6).
description: Published as part of Cook-Price, Dawn R., Petko, Olga N., Makchai, Sunchai, Artchawakom, Taksin & Suwanwaree, Pongthep, 2025, Mammal diversity survey of Ko Pha-ngan in Surat Thani Province, Thailand, pp. 77-102 in ZooKeys 1229 on pages 77-102, DOI: 10.3897/zookeys.1229.118127
Hydrogen Radio Recombination Line Emission from M51 and NGC628
Creators: name: Luisi, Matteo
name: Anderson, L. D.
name: Bania, T. M.
name: Balser, Dana S.
name: Wenger, Trey V.
name: Kepley, Amanda A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the discovery of hydrogen radio recombination line (RRL) emission from two galaxies with star formation rates (SFRs) similar to that of the Milky Way: M51 and NGC628. We use the Green Bank Telescope (GBT) to measure $\sim$15 Hn$α$ recombination transitions simultaneously and average these data to improve our spectral signal-to-noise ratio. We show that our data can be used to estimate the total ionizing photon flux of these two sources, and we derive their SFRs within the GBT beam: $Ψ_{\rm OB} = 3.46$ M$_{\odot}$ yr$^{-1}$ for M51 and $Ψ_{\rm OB} = 0.56$ M$_{\odot}$ yr$^{-1}$ for NGC628. Here, we demonstrate that it is possible to detect RRLs from normal galaxies that are not undergoing a starburst with current instrumentation and reasonable integration times ($\sim$12 hr for each source). We also show that we can characterize the overall star-forming properties of M51 and NGC628, although the GBT beam cannot resolve individual HII region complexes. Our results suggest that future instruments, such as the Square Kilometre Array and the Next Generation Very Large Array, will be able to detect RRL emission from a multitude of Milky Way-like galaxies, making it possible to determine SFRs of normal galaxies unaffected by extinction and to measure global star formation properties in the local universe.
description: 8 pages, 1 figure, 3 tables; Accepted for publication in PASP
El juego como una herramienta pedagógica para el aprendizaje en la escuela
Creators: name: Uribe-Delgado, Andrés
Publisher: name: Zenodo
Year: 2024

description: El juego es una actividad innata del ser humano caracterizada por la producción de placer y por sus beneficios asociados en la dimensión física, psicológica y social. El objetivo de este ensayo consiste en analizar, interpretar y develar antecedentes que contribuyan a la reproducción de prácticas educativas en base al juego. El método utilizado consiste en un análisis de contenidos publicados en la literatura científica, normativa y de divulgación científica para la profundización teórica de las diferentes miradas del juego como herramienta pedagógica. Se propone una clasificación de tipos de juegos, basados en la literatura y se ejemplifica dando orden a través de una ficha de clasificación de juegos para ser utilizada en el contexto educativo escolar. Se concluye que el juego es un elemento importante dentro del proceso educativo dada sus características y su impacto en los estudiantes en la motivación y en la facilitación de nuevos aprendizajes. Asimismo, se defiende la idea del juego como herramienta pedagógica direccionada al cumplimiento de objetivos de aprendizaje a fin de contribuir a la didáctica en la escuela.
title: 01_2648
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: LaMOP

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 19: of Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
Creators: name: Johnson, Erik
name: Dammer, Eric
name: Duong, Duc
name: Luming Yin
name: Thambisetty, Madhav
name: Troncoso, Juan
name: Lah, James
name: Levey, Allan
name: Seyfried, Nicholas
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Figure S12. Correlation Between Alternative Exon-Exon Junctions Quantified by TMT-LysC and LFQ-trypsin Analyses. Alternative exon-exon junctions (alt-EEjxns) that were identified and quantified in both TMT-LysC and LFQ-trypsin analyses (n = 1202 alt-EEjxns) and which had no missing values across the 47 BLSA cases were matched case-to-case, and the log(2) normalized intensity measurements for each alt-EEjxn were correlated between the two quantification approaches. Note that the peptide containing the alt-EEjxn is not necessarily identical between TMT-LysC and LFQ-trypsin analyses. When the correlation is restricted to identical alt-EEjxn peptides (n = 728), the strength of correlation increases only slightly (r = 0.6) (data not shown). (PDF 15000 kb)
Neutron star bulk viscosity, "spin-flip" and GW emission of newly born magnetars
Creators: name: Dall'Osso, Simone
name: Stella, Luigi
name: Palomba, Cristiano
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The viscosity-driven "spin-flip" instability in newborn magnetars with interior toroidal magnetic fields is re-examined. We calculate the bulk viscosity coefficient ($ζ$) of cold, $npe μ$ matter in neutron stars (NS), for selected values of the nuclear symmetry energy and in the regime where $β$-equilibration is slower than characteristic oscillation periods. We show that: i) $ζ$ is larger than previously assumed and the instability timescale correspondingly shorter; ii) for a magnetically-induced ellipticity $ε_B \lesssim 4 \times 10^{-3}$, typically expected in newborn magnetars, spin-flip occurs for initial spin periods $\lesssim 2-3$ ms, with some dependence on the NS equation of state (EoS). We then calculate the detectability of GW signals emitted by newborn magnetars subject to "spin-flip", by accounting also for the reduction in range resulting from realistic signal searches. For an optimal range of $ε_B \sim (1-5) \times 10^{-3}$, and birth spin period $\lesssim 2$ ms, we estimate an horizon of $\gtrsim 4$ Mpc, and $\gtrsim 30$ Mpc, for Advanced and third generation interferometers at design sensitivity, respectively. A supernova (or a kilonova) is expected as the electromagnetic counterpart of such GW events. Outside of the optimal range for GW emission, EM torques are more efficient in extracting the NS spin energy, which may power even brighter EM transients.
description: 10 pages, 4 figures, accepted for publication in MNRAS
Role of human interleukin-17 producing T cells (Th17) and regulatory (Foxp3+) T cells in graft versus host disease (GvHD)
Creators: name: Alsuliman, Abdullah Saleh A
Publisher: name: Imperial College London
Year: 2013

description: Allogeneic stem cell transplantation (AHSCT) remains the only curative option for a number of patients with haematological malignancies. The interplay between a number of T cell subsets including Th1, Th2, Th17 and regulatory-T cells (Treg) has been linked to the establishment of graft-versus-leukaemia (GvL) as well as its deleterious counterpart graft-versus-host-disease (GvHD). A recent study defined a subset of memory antigen-specific CD8+T cells, with the ability to efflux cytotoxic drugs through the (ABC)-superfamily multidrug efflux complex. I hypothesized that a subset of CD4+T cells, capable of drug efflux through the MDR pump also exists. I confirmed the existence of CD4+T cells with "stem-like" properties, capable of rapidly effluxing Rhodamine123 as well as cytotoxic drugs such as daunorubicin. I confirmed that the effluxing properties of these cells are through ABCB1 and ABCC1 transporters. Similar to their CD8 counterpart, the rhodamine-effluxing subset of CD4+T cells had a memory phenotype and was enriched within the CD161+T cell compartment. Lastly, using CMV and Flu as model antigens, I showed that viral-specific memory CD4+T cells are enriched within the rhodamine-effluxing CD4+CD161+T cell population. Once I characterized these cells, I hypothesized that, through effluxing corticosteroids and other immunosuppressant drugs,CD161+CD4+ T cells may also play a role in acute GvHD. CD161+CD4+ T cells are precursors of Th17 cells. I demonstrated that, whereas Tregs are prone to apoptosis when exposed to corticosteroids, CD4+CD161+Th17 cells rapidly efflux and survive exposure to corticosteroids and other immunosuppressive drugs in vitro. Inhibition of the ABCB1 and ABCC1 with inhibitors such as vinblastine induced apoptosis of this CD4+CD161+Th17 steroid-refractory T cell subset. I observed that patients with steroid-refractory GvHD had significantly higher frequencies of CD161+CD4+ T cells compared to patients with no or steroid-responsive GvHD. I also enumerated CD161+CD4+ T cells and Foxp3+T cells in the stem cell graft and donor lymphocytes and found an association between higher CD4+CD161+ and lower Foxp3+T cells frequencies and the risk of GvHD post-transplant. These data advance our understanding of potential mechanisms of steroid-refractory GvHD and have important implications for the development of novel therapeutic approaches for the treatment of this challenging group of patients.
Towards an open ambidextrous system : how organizations manage exploration and exploitation in open innovation environments
Creators: name: Alduaij, Manal Yousuf S. A.
Publisher: name: Imperial College London
Year: 2013

description: This research examines the telecommunication industry and uses it as an example in order to present a general model of how ambidexterity is carried out in the context of open innovation. This emerging approach to ambidexterity has been particularly evident in the telecommunication industry where exploration and exploitation activities are established on information technology structures. Ambidexterity is the idea that successful firms simultaneously explore new ideas while exploiting existing ones in order to sustain profitability, especially in dynamic environments. Few studies have discussed ambidexterity that is carried out in contexts of open innovation. For this reason, this doctoral thesis addresses this gap in our understanding of ambidexterity, and contributes to it by examining the question: "How do ambidextrous organizations carry out exploration and exploitation in open innovation environments?" A new form of ambidexterity has been identified in this study; it is an open ambidextrous system. It exists in a particularly transparent form around organizations whose innovation activities are focused on information technology infrastructure, specifically networking technologies, as has been evident in the telecommunication industry. This presents important implications for the management information systems (MIS) literature. Open ambidextrous systems are established by organizations when they manage exploration and exploitation in open innovation environments. From that understanding ambidexterity has been identified as open. This offers important insight for the ambidexterity and open innovation literatures. As a result, organizations that adopt an open ambidextrous system are recognized as performing open exploration and open exploitation, where the two activities are perceived as two complementing systems identified as the open exploration system, and the open exploitation system. Therefore, this research combines insights from the ambidexterity, open innovation, and management information systems literatures, and contributes to them by offering a new and alternative view to ambidexterity that is based on the open innovation notion.
Oral history interview with Lionel Abel, 1992
Publisher: name: Columbia University
Year: 2021

description: Childhood, Joplin, MO, Roanoke, VA, Niagara Falls, NY; father's vocation as rabbi, muted sense of Jewish identity; University of North Carolina; Move to Greenwich Village 1929, intellectual life of "Village," Romany Marie’s, bohemian tradition of Village; Works Projects Administration (WPA); New York in the 1930s; radicalism, marches, Socialist Party, politics, sectarianism, stature of Leon Trotsky among American intellectuals; Partisan Review, evaluation of; Communist Party (US), World War II; post-war intellectual trends, modernism, New York as art center, role of intellectuals in public life, failure of the organized left; McCarthyism; commentary on idea of "New York intellectuals"
The symbiotic contact process: phase transitions, hysteresis cycles, and bistability
Creators: name: Filho, C. I. N. Sampaio
name: Santos, T. B. dos
name: Araújo, N. A. M.
name: Carmona, H. A.
name: Moreira, A. A.
name: Andrade, J. S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We performed Monte Carlo simulations of the symbiotic contact process on different spatial dimensions ($d$). On the complete and random graphs (infinite dimension), we observe hysteresis cycles and bistable regions, what is consistent with the discontinuous absorbing-state phase transition predicted by mean-field theory. By contrast, on a regular square lattice, we find no signs of bistability or hysteretic behavior. This result suggests that the transition in two dimensions is rather continuous. Based on our numerical observations, we conjecture that the nature of the transition changes at the upper critical dimension ($d_c$), from continuous ($dd_c$).
description: 6 pages, 6 figures
MOESM9 of The methylome of the marbled crayfish links gene body methylation to stable expression of poorly accessible genes
Creators: name: Gatzmann, Fanny
name: Falckenhayn, Cassandra
name: Gutekunst, Julian
name: Hanna, Katharina
name: GĂźnter Raddatz
name: Vitor Carneiro
name: Lyko, Frank
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 9. ATAC-seq quality controls showing library quality (top left), pairwise comparisons of ATAC peak intensities from three independent libraries and a representative Genome Browser screen shot of read enrichment (bottom panel).
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Cart. 189 (11 H 74), 316 folios, f. 0165r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0165r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0165r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
MPEC 2024-D72 : 2024 DU
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 DU

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Dual velocity-component investigation of transient growth in the Blasius boundary layer
Creators: name: Roldan Becerra, Ivan H.
Publisher: name: Imperial College London
Year: 2013

description: Transient growth of finite three-dimensional perturbations in wall-bounded laminar shear flows has been extensively studied theoretical, numerical and experimentally. With regard to the experimental work, the vast majority of the investigations have been focused only on the behaviour of the streamwise velocity component, u', despite the importance of the spanwise gradient of the wall-normal velocity component, [Symbols appear here. To view, please open pdf attachment], as the forcing agent. The present study provides a step forward in the experimental characterisation of transient growth providing, by Laser Doppler Anemometry, simultaneous and highly spatially resolved measurements of both streamwise and wall-normal velocity components of three-dimensional disturbances embedded in a two-dimensional laminar boundary layer. The disturbances are deterministic, as they are generated by a spanwise array of cylindrical roughness elements. The readings are concentrated in both the wake and u'-energy growth regions. Contrary to non-normal operator theory, which describes transient growth as a linear mechanism, a spectral analysis in the present study demonstrates that there exists an underlying non-linear mechanism. This non-linear behaviour is attributed to the influence of the wake in the u'-energy growth region. Numerical simulations considering non-linear terms confirm this conclusion. Both spectral and wavelet analyses have been conducted, providing information regarding the spatial location of the components of the perturbation as well as the relationship between the scales of motion. The numerical simulations are also employed as a workbench to design actuators for open-loop control of transient growth.