cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Glycerophospholipid and sphingolipid species and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Creators: name: Sigrüner, Alexander
name: Kleber, Marcus E.
name: Heimerl, Susanne
name: Liebisch, Gerhard
name: Schmitz, Gerd
name: März, Winfried
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: CORONARY-ARTERY-DISEASE; PALMITATE-INDUCED APOPTOSIS; TANDEM MASS-SPECTROMETRY; FREE FATTY-ACIDS; LIPIDOMICS REVEALS; GENETIC-VARIATION; PLASMA; CERAMIDE; LYSOPHOSPHATIDYLCHOLINE; IDENTIFICATION;
subject: 610 Medizin

description: Vascular and metabolic diseases cause half of total mortality in Europe. New prognostic markers would provide a valuable tool to improve outcome. First evidence supports the usefulness of plasma lipid species as easily accessible markers for certain diseases. Here we analyzed association of plasma lipid species with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Plasma lipid species were quantified by electrospray ionization tandem mass spectrometry and Cox proportional hazards regression was applied to assess their association with total and cardiovascular mortality. Overall no differences were detected between total and cardiovascular mortality. Highly polyunsaturated phosphatidylcholine species together with lysophosphatidylcholine species and long chain saturated sphingomyelin and ceramide species seem to be associated with a protective effect. The predominantly circulating phosphatidylcholine-based as well as phosphatidylethanolamine-based ether species and phosphatidylethanolamine species were positively associated with total and cardiovascular mortality. Saturated and monounsaturated phosphatidylcholine species, especially phosphatidylcholine 32:0 (most probably dipalmitoyl-phosphatidylcholine) and palmitate containing sphingomyelin and ceramide species showed together with 24:1 containing sphingomyelin and ceramide species strongest positive association with mortality. A quotient of the sums of the six most protective species and the six species with the strongest positive mortality association indicated an almost 3-fold increased risk of mortality, which was higher than the hazard ratio for known risk factors in our cohort. Plasma lipid species levels and especially ratios of certain species may be valuable prognostic marker for cardiovascular and total mortality.
Clytocerus undetermined
Creators: name: Wagner, Rüdiger
name: Andrade, Rui
name: Gonçalves, Ana
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Clytocerus
Clytocerus undetermined

description: Clytocerus sp.
Material: 1♀, Portugal, Bragança, Espinhosela (Parque Natural de Montesinho), 9 September 2014 (collected with male of C. ibericus).
description: Published as part of Wagner, Rüdiger, Andrade, Rui & Gonçalves, Ana, 2022, Moth flies (Diptera, Psychodidae) from Portugal with descriptions of a new genus new species and additions to the fauna of the Iberian Peninsula, pp. 37-59 in Zootaxa 5129 (1) on page 48, DOI: 10.11646/zootaxa.5129.1.2, http://zenodo.org/record/6488081
Adipose tissue-derived Stem Cell (ASC) secreted IGF-1 protects myoblasts from the negative effect of Myostatin
Creators: name: Gehmert, Sebastian
name: Wenzel, Carina
name: Loibl, Markus
name: Brockhoff, Gero
name: Huber, Michaela
name: Krutsch, Werner
name: Nerlich, Michael
name: Gosau, Martin
name: Klein, Silvan
name: Schreml, Stephan
name: Prantl, Lukas
name: Gehmert, Sanga
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: DUCHENNE MUSCULAR-DYSTROPHY; INDUCED MUSCLE DAMAGE; SKELETAL-MUSCLE; CONTRACTILE FUNCTION; GENE-EXPRESSION; CYCLIN D1; GROWTH; DIFFERENTIATION; PROLIFERATION; MICE;
subject: 610 Medizin

description: Myostatin, a TGF-beta family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Muscular Dystrophy (DMD). But the protective effect of stem cell secreted IGF-1 on myoblast under high level of myostatin remains unclear. In the present study murine myoblasts were exposed to myostatin under presence of ASCs conditioned medium and investigated for proliferation and apoptosis. The protective effect of IGF-1 was further examined by using IGF-1 neutralizing and receptor antibodies as well as gene silencing RNAi technology. MyoD expression was detected to identify impact of IGF-1 on myoblasts differentiation when exposed to myostatin. IGF-1 was accountable for 43.6% of the antiapoptotic impact and 48.8% for the proliferative effect of ASCs conditioned medium. Furthermore, IGF-1 restored mRNA and protein MyoD expression of myoblasts under risk. Beside fusion and transdifferentiation the beneficial effect of ASCs is mediated by paracrine secreted cytokines, particularly IGF-1. The present study underlines the potential of ASCs as a therapeutic option for Duchenne muscular dystrophy and other dystrophic muscle diseases.
Direct cell-cell contact between Mesenchymal Stem Cells and Endothelial Progenitor Cells induces a Pericyte-like phenotype in vitro
Creators: name: Loibl, Markus
name: Binder, Andreas
name: Hermann, Marietta
name: Duttenhoefer, Fabian
name: Richards, Geoff R.
name: Nerlich, Michael
name: Alini, Mauro
name: Verrier, Sophie
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: HUMAN BONE-MARROW; HUMAN-TISSUES; ANGIOGENESIS; DIFFERENTIATION; EXPRESSION; EXPANSION; CD34(+); BRAIN;
subject: 610 Medizin

description: Tissue engineering techniques for the regeneration of large bone defects require sufficient vascularisation of the applied constructs to ensure a sufficient supply of oxygen and nutrients. In our previous work, prevascularised 3D scaffolds have been successfully established by coculture of bone marrow derived stem cells (MSCs) and endothelial progenitor cells (EPCs). We identified stabilising pericytes (PCs) as part of newly formed capillary-like structures. In the present study, we report preliminary data on the interactions between MSCs and EPCs, leading to the differentiation of pericyte-like cells. MSCs and EPCs were seeded in transwell cultures, direct cocultures, and single cultures. Cells were cultured for 10 days in IMDM 10% FCS or IMDM 5% FCS 5% platelet lysate medium. Gene expression of PC markers, CD146, NG2, alpha SMA, and PDGFR-beta, was analysed using RT-PCR at days 0, 3, 7, and 10. The upregulation of CD146, NG2, and alpha SMA in MSCs in direct coculture with EPCs advocates the MSCs' differentiation towards a pericyte-like phenotype in vitro. These results suggest that pericyte-like cells derive from MSCs and that cell-cell contact with EPCs is an important factor for this differentiation process. These findings emphasise the concept of coculture strategies to promote angiogenesis for cell-based tissue engineered bone grafts.
Elachista tephrina Kaila 2015
Creators: name: Kaila, Lauri
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Elachistidae
Elachista
Elachista tephrina

description: Elachista tephrina Kaila, 2015
Elachista tephrina Kaila, 2015c: 398. Type locality: Kyrgyzstan, Naryn env. (Kaila 2015c: 398). Holotype ♂, in MZH.
Subgenus: Elachista; bifasciella species group.
Distribution: Palearctic. Kyrgyzstan.
Larval host plant(s): unknown.
Figs.: Kaila (2015c).
Remarks: Report of E. subnigrella Douglas from Kyrgyzstan (Kaila 1992: 184) is referable to E. tephrina Kaila, 2015 (Kaila 2015c: 317, 318).
description: Published as part of Kaila, Lauri, 2019, An annotated catalogue of Elachistinae of the World (Lepidoptera: Gelechioidea: Elachistidae), pp. 1-231 in Zootaxa 4632 (1) on page 131, DOI: 10.11646/zootaxa.4632.1.1, http://zenodo.org/record/3335414
Siler Simon 1889
Creators: name: Wang, Cheng
name: Mi, Xiaoqi
name: Li, Shuqiang
name: Xu, Xiang
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Siler

description: GenusSilerSimon, 1889
Type species.
Siler cupreus Simon, 1889; type locality Yokohama, Japan.
Comments.
Siler, a member of Chrysillini, comprises 12 species, mainly distributed in east and southeast Asia (Maddison 2015; WSC 2024). The genus has not been revised recently. Like most salticid genera, a high rate (58.3 %) of its species are known only from a single sex. In addition, three species are only known from the original description, and S. pulcher Simon, 1901 has never been illustrated (WSC 2024).
description: Published as part of Wang, Cheng, Mi, Xiaoqi, Li, Shuqiang & Xu, Xiang, 2024, Taxonomic notes of jumping spiders (Araneae, Salticidae) from Guangxi, Hainan, Sichuan, Xizang and Yunnan, China, pp. 205-277 in ZooKeys 1221 on pages 205-277, DOI: 10.3897/zookeys.1221.135640
FysikLab@SDU-Galaxy: Project-based learning & didactics. Astronomy in the class-room. FysikLab får besøg af Mulernes Legatskole. 13. november 2024.
Creators: name: Hinse, Tobias Cornelius
Publisher: name: Zenodo
Year: 2024

description: 2.g og 3.g elever fra Mulernes Legatskole besøger SDU FysikLab og lærer mere om astronomi og exoplaneter.
Lipidomic analysis of serum from high-fat diet induced obese mice
Creators: name: Eisinger, Kristina
name: Liebisch, Gerhard
name: Schmitz, Gerd
name: Aslanidis, Charalampos
name: Krautbauer, Sabrina
name: Büchler, Christa
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: HIGH-THROUGHPUT QUANTIFICATION; SPECTROMETRY ESI-MS/MS; INSULIN-RESISTANCE; MASS-SPECTROMETRY; CERAMIDE; PLASMA; CHOLESTEROL; PHOSPHATIDYLCHOLINE; ADIPOKINE; ACIDS; phospholipids; lysophosphatidylcholine; lipidomic profiling; obesity; serum
subject: 610 Medizin

description: Lipid metabolites regulate fatty acid and glucose homeostasis. The intention of the current study is to identify circulating lipid species, which are altered in rodent obesity and strongly correlate with the classically measured metabolites glucose, triglycerides, and cholesterol. Mice fed a high fat diet (HFD) for 14 weeks have increased body weight and fasting glucose. Serum triglycerides are not altered, while cholesterol tends to be increased. Accordingly, major cholesteryl ester (CE) species and free cholesterol are not significantly raised in obesity while minor metabolites, including CE 20:3 and CE 18:3, are increased or reduced, respectively. Distinct sphingomyelin (SM) species are elevated while ceramides are not raised. Phosphatidylinositol (PI) species, including PI 34:1, are raised while others are decreased. PI 34:1 strongly correlates with fasting glucose and proinsulin levels. Phosphatidylcholine (PC) 26:0, 40:2, and 40:5, which are induced in obesity, correlate with cholesterol. PC 38:4 and PC 40:6 are also raised in fat fed mice and positively correlate with fasting glucose. Lysophosphatidylcholine (LPC) species are also changed in obesity and the already shown reduction of LPC 16:1 has been confirmed. LPC 22:4, which is increased, correlates with serum cholesterol. The data indicate that circulating levels of various lipid species are changed in the obesity model studied and some of them are strongly associated with classically measured metabolites.
Making Landscapes of Dispossession Visible
Creators: name: Luevano, Lizbeth
Publisher: name: Stanford Digital Repository
Year: 2025
Subjects: Necropolotics
Bare life
Dispossession
Story reclamation

description: This project prompts viewers to consider what are the silences occurring throughout a landscape and what is the labor that has been made invisible? Situated in the Coachella Valley, this project explores the environmental hazards that communities of migrant field workers are routinely exposed to and the landscapes of dispossession that consequently rise.
Xiphocentron (Sphagocentron) julus Schmid 1982
Creators: name: Vilarino, Albane
name: Calor, Adolfo R.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Xiphocentronidae
Xiphocentron
Xiphocentron julus

description: Xiphocentron (Sphagocentron) julus Schmid, 1982
Figures 10 A – C
Schmid 1982: 56 [Type locality: Holotype MEXICO • ♂; Veracruz, Puente Nacional, USNM]. — Armitage et al. 2018: 3 [distribution]. — Harris and Armitage 2019: 7 [distribution]. — Armitage et al. 2021: 8 [distribution]. — Bueno-Soria et al. 2022: 201 [checklist].
Material examined.
MEXICO • ♂; Veracruz, Puente Nacional, 15. vi. 1964, F. S. Blanton leg., USNM.
Diagnosis.
Xiphocentron julus is particularly similar to X. tampati sp. nov. by the posterior margin of sternum IX mostly straight with very small mesal lobes; and can be differentiated from this and other species mainly by the uniform width of the preanal appendage, the posterior margin of sternum IX mostly straight with very small mesal lobes, and the paraproct apex oblique.
Synopsis.
Male. Forewing length 4.0 mm. Color overall brown, forewing uniformly dark brown. Genitalia (Fig. 10 A – C). Tergum IX in lateral view, wide basally, narrower apically (Fig. 10 A); in dorsal view, posterior margin with two ogival shaped lobes and small lateral flanges (Fig. 10 B). Sternum IX, in ventral view, posterior margin abruptly truncated, straight at its ventro-apical margin, forming two low lobes, barely produced (Fig. 10 C). Paraproct, in lateral view, slender tapering to a pointed apex (Fig. 10 A); in dorsal view, apex round and forming two apical lobes (Fig. 10 B). Preanal appendage in lateral view, regularly narrow and pointed at apex (Fig. 10 A). Inferior appendage, in lateral view, about 2.5 × as long as tergum IX, coxopodite and harpago completely fused to each article, inner face with longitudinal area of dense, long spine-like setae, and row of regular setae from midlenght to apex (Fig. 10 A); basal region (coxopodite) wide, mesal sclerite region indistinct; apical region (harpago) narrow, digitate 2 × as long as basal region, curved dorsad (Fig. 10 A); in dorsal view, strongly curved mesad, apex twisted posterad (Fig. 10 B). Phallus tubular, very long and narrow, reaching segment V, basally conical, subapically annulate, weakly sclerotized, apex enlarged.
Distribution.
Mexico, Panama.
Remarks.
Type was fixed in a permanent slide and displayed in lateral view.
description: Published as part of Vilarino, Albane & Calor, Adolfo R., 2024, Comparative geometric morphometrics of male genitalia in Xiphocentron subgenera (Trichoptera: Xiphocentronidae): new species, revision and phylogenetic systematics of the subgenus Sphagocentron, pp. 407-431 in Arthropod Systematics & amp; Phylogeny 82 on pages 407-431, DOI: 10.3897/asp.82.e112587
Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects
Creators: name: Baessler, A.
name: Lamounier-Zepter, V.
name: Fenk, S.
name: Strack, C.
name: Lahmann, C.
name: Loew, Thomas H.
name: Schmitz, Gerd
name: Blüher, M.
name: Bornstein, Stefan R.
name: Fischer, M.
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: NORMAL EJECTION FRACTION; METABOLIC SYNDROME; HEART-FAILURE; DISEASE; AP2; ECHOCARDIOGRAPHY; ABNORMALITIES; POPULATION; MORTALITY; DIAGNOSIS; diastolic dysfunction; obesity; metabolic syndrome; fatty acid-binding protein-4
subject: 610 Medizin

description: OBJECTIVES: This study aimed to examine the association of adipocyte fatty acid-binding protein (FABP4) levels with left ventricular diastolic dysfunction (LVDD) in obese subjects with varying degrees of the metabolic syndrome (MetS). METHODS: Fifty morbidly obese subjects with LVDD were selected at random and matched by age (+/- 5 years) and sex with 50 morbidly obese with normal left ventricular (LV) function. In addition, 24 healthy lean subjects were included as controls. RESULTS: Median FABP4 levels (interquartile range) in obese subjects with LVDD were significantly higher (42 ng ml(-1) (32-53)) than in obese with normal LV function (24 ng ml(-1) (36-43), P = 0.036), and in normal weight controls (13 ng ml(-1) (10-20), P<0.0001). Increasing FABP4 tertiles were significantly associated with parameters of LVDD, the number of LVDD components, physical performance and epicardial fat thickness. In multivariate regression analysis adjusting for age, sex and adiposity, FABP4 levels remained significantly associated with parameters of diastolic function. The association of FABP4 levels with LVDD was mainly observed in subjects with metabolic complications, but not in metabolically healthy obese. CONCLUSIONS: FABP4 levels are significantly associated with LVDD in obese subjects, when the MetS is present. Thus, FABP4 may be a link between obesity and cardiometabolic disorders.
Elachista tersella
Creators: name: Kaila, Lauri
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Elachistidae
Elachista
Elachista tersella

description: Elachista tersella (Sinev & Sruoga, 1995)
Biselachista tersella Sinev & Sruoga, 1995: 136. Type locality: Russia, Primorsky Krai, Ussuriysky District, Gornotaeyezhnoe (Sinev & Sruoga 1995: 136). Holotype ♂, in ZISP.
Elachista tersella: Kaila (1999a: 169).
Subgenus: Elachista; tetragonella species group.
Distribution: Palearctic. Russia (E. Russia).
Larval host plant(s): unknown.
Figs.: Sinev & Sruoga (1995).
description: Published as part of Kaila, Lauri, 2019, An annotated catalogue of Elachistinae of the World (Lepidoptera: Gelechioidea: Elachistidae), pp. 1-231 in Zootaxa 4632 (1) on page 131, DOI: 10.11646/zootaxa.4632.1.1, http://zenodo.org/record/3335414
Phenotypic Characteristics of Hyperacusis in Tinnitus
Creators: name: Schecklmann, Martin
name: Landgrebe, Michael
name: Langguth, Berthold
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: GENERALIZED HYPERVIGILANCE; DISORDERS; NOISE; SOUND; HYPERSENSITIVITY; INDIVIDUALS; ASSOCIATION; SENSITIVITY; PREVALENCE; EXPOSURE;
subject: 610 Medizin

description: Background: Many people with tinnitus also suffer from hyperacusis. Both clinical and basic scientific data indicate an overlap in pathophysiologic mechanisms. In order to further elucidate the interplay between tinnitus and hyperacusis we compared clinical and demographic characteristics of tinnitus patients with and without hyperacusis by analyzing a large sample from an international tinnitus patient database. Materials: The default dataset import [November 1st, 2012] from the Tinnitus Research Initiative [TRI] Database was used for analyses. Hyperacusis was defined by the question "Do sounds cause you pain or physical discomfort?" of the Tinnitus Sample Case History Questionnaire. Patients who answered this question with "yes" were contrasted with "no"-responders with respect to 41 variables. Results: 935 [55%] out of 1713 patients were characterized as hyperacusis patients. Hyperacusis in tinnitus was associated with younger age, higher tinnitus-related, mental and general distress; and higher rates of pain disorders and vertigo. In relation to objective audiological assessment patients with hyperacusis rated their subjective hearing function worse than those without hyperacusis. Similarly the tinnitus pitch was rated higher by hyperacusis patients in relation to the audiometrically determined tinnitus pitch. Among patients with tinnitus and hyperacusis the tinnitus was more frequently modulated by external noise and somatic maneuvers, i.e., exposure to environmental sounds and head and neck movements change the tinnitus percept. Conclusions: Our findings suggest that the comorbidity of hyperacusis is a useful criterion for defining a sub-type of tinnitus which is characterized by greater need of treatment. The higher sensitivity to auditory, somatosensory and vestibular input confirms the notion of an overactivation of an unspecific hypervigilance network in tinnitus patients with hyperacusis.
title: L'histoire de la brisure des répliques en physique : entretien avec Marc Mézard
title: History of Replica Symmetry Breaking in Physics : Interview with Marc Mézard
Creators: name: Charbonneau, Patrick
name: Marc, Mézard
name: Zamponi, Francesco
name: Mézard, Marc (1957-....)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Physics--History--20th century

description: Transcription de l'entretien enregistré par Zoom, depuis son bureau à Bocconi University (Milan, Italie), le 14 novembre 2022
description: Transcript of an oral history conducted on the morning of November 14, 2023, over Zoom, from his office at Bocconi University in Milano, Italy
Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study
Creators: name: Enger, Tone Bull
name: Philipp, Alois
name: Videm, Vibeke
name: Ludnow, Matthias
name: Wahba, Alexander
name: Fischer, Marcus
name: Schmid, Christof
name: Bein, Thomas
name: Müller, Thomas
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: RESPIRATORY-DISTRESS-SYNDROME; PREOPERATIVE ANEMIA; RANDOM FORESTS; SCORE; RISK; ECMO;
subject: 610 Medizin

description: Introduction: Veno-venous extracorporeal membrane oxygenation (vvECMO) can be a life-saving therapy in patients with severe acute lung failure refractory to conventional therapy. Nevertheless, vvECMO is a procedure associated with high costs and resource utilization. The aim of this study was to assess published models for prediction of mortality following vvECMO and optimize an alternative model. Methods: Established mortality risk scores were validated to assess their usefulness in 304 adult patients undergoing vvECMO for refractory lung failure at the University Medical Center Regensburg from 2008 to 2013. A parsimonious prediction model was developed based on variables available before ECMO initiation using logistic regression modelling. We then assessed whether addition of variables available one day after ECMO implementation enhanced mortality prediction. Models were internally validated and calibrated by bootstrapping (400 runs). Predictive ability, goodness-of-fit and model discrimination were compared across the different models. Results: In the present study population, existing mortality prediction tools for vvECMO patients showed suboptimal performance. Evaluated before vvECMO initiation, a logistic prediction model comprising age, immunocompromised state, artificial minute ventilation, pre-ECMO serum lactate and hemoglobin concentrations showed best mortality prediction in our patients (area under curve, AUC: 0.75). Additional information about norepinephrine dosage, fraction of inspired oxygen, C-reactive protein and fibrinogen concentrations the first day following ECMO initiation further improved discrimination (AUC: 0.79, P = 0.03) and predictive ability (likelihood ratio test, P < 0.001). When classifying patients as lower (< 40%) or higher (> 80%) risk based on their predicted mortality, the pre-ECMO and day1-on-ECMO models had negative/positive predictive values of 76%/82% and 82%/81%, respectively. Conclusions: While pre-ECMO mortality prediction remains a challenge due to large patient heterogeneity, evaluation one day after ECMO initiation may improve the ability to separate lower-and higher-risk patients. Our findings support the clinical perception that chronic health condition, high comorbidity and reduced functional reserves are strongly related to survival during and following ECMO support. Renewed evaluation the first day after ECMO initiation may provide enhanced guidance for further handling of ECMO patients. Despite the usefulness of prediction models, thorough clinical evaluation should always represent the cornerstone in decision for ECMO.
Which tinnitus-related aspects are relevant for quality of life and depression: results from a large international multicentre sample
Creators: name: Zeman, Florian
name: Koller, Michael
name: Langguth, Berthold
name: Landgrebe, Michael
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: PSYCHOMETRIC PROPERTIES; HANDICAP INVENTORY; OLDER-ADULTS; SEVERITY; QUESTIONNAIRE; POPULATION; STRATEGIES; SUFFERERS; SYMPTOMS; INSOMNIA; Tinnitus; Tinnitus handicap inventory; Tinnitus severity; Quality of life; Depression
subject: 610 Medizin

description: Background: The aim of the present study was to investigate, which aspects of tinnitus are most relevant for impairment of quality of life. For this purpose we analysed how responses to the Tinnitus Handicap Inventory (THI) and to the question "How much of a problem is your tinnitus at present" correlate with the different aspects of quality of life and depression. Methods: 1274 patients of the Tinnitus Research Initiative database were eligible for analysis. The Tinnitus Research Initiative database is composed of eight study centres from five countries. We assessed to which extent the Tinnitus Handicap Inventory (THI) and its subscales and single items as well as the tinnitus severity correlate with Beck Depression Inventory (BDI) score and different domains of the short version of the WHO-Quality of Life questionnaire (WHO-QoL Bref) by means of simple and multiple linear regression models. Results: The THI explained considerable portions of the variance of the WHO-QoL Physical Health (R-2 = 0.39) and Psychological Health (R-2 = 0.40) and the BDI (R-2 = 0.46). Furthermore, multiple linear regression models which included each THI item separately explained an additional 5% of the variance compared to the THI total score. The items feeling confused from tinnitus, the trouble of falling asleep at night, the interference with job or household responsibilities, getting upset from tinnitus, and the feeling of being depressed were those with the highest influence on quality of life and depression. The single question with regard to tinnitus severity explained 18%, 16%, and 20% of the variance of Physical Health, Psychological Health, and BDI respectively. Conclusions: In the context of a cross-sectional correlation analysis, our findings confirmed the strong and consistent relationships between self-reported tinnitus burden and both quality of life, and depression. The single question "How much of a problem is your tinnitus" reflects tinnitus-related impairment in quality of life and can thus be recommended for use in clinical routine.
The effects of challenge and threat states on performance outcomes: An updated review and meta-analysis of recent findings
Creators: name: Hase, Adrian
name: Nietschke, Maximilian
name: Kłoskowski, Maciej
name: Szymański, Kacper
name: Moore, Lee
name: Jamieson, Jeremy P.
name: Behnke, Maciej
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2025
Subjects: challenge-threat index
demand resource evaluations
motivated performance
biopsychosocial
cognitive appraisal
psychophysiology

description: The biopsychosocial model (BPSM) of challenge and threat provides a framework for understanding stress responses in motivated performance situations, including how stress relates to performance. In this model, experiences of challenge—characterized by evaluations of personal coping resources matching or exceeding situational demands—elicit approach-oriented patterns of physiological responding and tend to facilitate performance, whereas threat—characterized by demands exceeding resources—elicit avoidance-oriented patterns of physiological responding and tend to impair performance. Extant systematic reviews and meta-analyses support the idea that challenge facilitates performance relative to threat (Behnke and Kaczmarek, 2018; Hase et al., 2019c). The present systematic review and meta-analysis builds on this evidence base by examining whether conclusions replicate in recent research (post-2017), which is important given seismic cultural shifts tied to a worldwide pandemic, civil unrest, and skyrocketing mental health problems tied to stress. The analysis included 62 studies published between 2017 and 2024 (total N = 7,418 participants). The meta-analytic findings indicate that individuals in a challenge state achieve better performance outcomes than those in a threat state across multiple domains (e.g., education, sport). While effect sizes were small, the risk of bias was generally low. These results reaffirm the utility of the BPSM and emphasize the importance of stress responses in influencing performance outcomes. These data also have the potential to inform future research on this topic by shedding light on expectable effect sizes and highlighting potential influences of publication bias and replicability issues.
description: EXCLI Journal; 24:Doc151; ISSN 1611-2156
Pericoma pseudoexquisita Tonnoir 1940
Creators: name: Wagner, Rüdiger
name: Andrade, Rui
name: Gonçalves, Ana
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Pericoma
Pericoma pseudoexquisita

description: Pericoma pseudoexquisita Tonnoir
Material: 2♂, Porto, Valongo, Campo e Sobrado, 1 October 2011; 1♂, ibidem 10 March 2014; 1♂, Braga, Esposende, Gemeses, 28 August 2010; 1♂, Guarda, Seia, Vide e Cabeça, 1 September 2014; 2♂, Guarda, Manteigas, São Pedro, 21 September 2013; 1♂, Guarda, Manteigas, São Pedro, 22 September 2013; 3♂, Guarda, Corujeira e Trinta, 22 September 2011.
description: Published as part of Wagner, Rüdiger, Andrade, Rui & Gonçalves, Ana, 2022, Moth flies (Diptera, Psychodidae) from Portugal with descriptions of a new genus new species and additions to the fauna of the Iberian Peninsula, pp. 37-59 in Zootaxa 5129 (1) on page 48, DOI: 10.11646/zootaxa.5129.1.2, http://zenodo.org/record/6488081
Monocyte to Macrophage Differentiation Goes along with Modulation of the Plasmalogen Pattern through Transcriptional Regulation
Creators: name: Wallner, Stefan
name: Grandl, Margot
name: Konovalova, Tatiana
name: Sigrüner, Alexander
name: Kopf, Thomas
name: Peer, Markus
name: Orsó, Evelyn
name: Liebisch, Gerhard
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: TANDEM MASS-SPECTROMETRY; PARTIAL LEAST-SQUARES; OXIDATIVE STRESS; MICROARRAY DATA; FACTOR EGR-1; CHOLESTEROL; PROTEIN; HSP70; INFLAMMATION; LIPOPROTEIN;
subject: 610 Medizin

description: Background: Dysregulation of monocyte-macrophage differentiation is a hallmark of vascular and metabolic diseases and associated with persistent low grade inflammation. Plasmalogens represent ether lipids that play a role in diabesity and previous data show diminished plasmalogen levels in obese subjects. We therefore analyzed transcriptomic and lipidomic changes during monocyte-macrophage differentiation in vitro using a bioinformatic approach. Methods: Elutriated monocytes from 13 healthy donors were differentiated in vitro to macrophages using rhM-CSF under serum-free conditions. Samples were taken on days 0, 1, 4 and 5 and analyzed for their lipidomic and transcriptomic profiles. Results: Gene expression analysis showed strong regulation of lipidome-related transcripts. Enzymes involved in fatty acid desaturation and elongation were increasingly expressed, peroxisomal and ER stress related genes were induced. Total plasmalogen levels remained unchanged, while the PE plasmalogen species pattern became more similar to circulating granulocytes, showing decreases in PUFA and increases in MUFA. A partial least squares discriminant analysis (PLS/DA) revealed that PE plasmalogens discriminate the stage of monocyte-derived macrophage differentiation. Partial correlation analysis could predict novel potential key nodes including DOCK1, PDK4, GNPTAB and FAM126A that might be involved in regulating lipid and especially plasmalogen homeostasis during differentiation. An in silico transcription analysis of lipid related regulation revealed known motifs such as PPAR-gamma and KLF4 as well as novel candidates such as NFY, RNF96 and Zinc-finger proteins. Conclusion: Monocyte to macrophage differentiation goes along with profound changes in the lipid-related transcriptome. This leads to an induction of fatty-acid desaturation and elongation. In their PE-plasmalogen profile macrophages become more similar to granulocytes than monocytes, indicating terminal phagocytic differentiation. Therefore PE plasmalogens may represent potential biomarkers for cell activation. For the underlying transcriptional network we were able to predict a range of novel central key nodes and underlying transcription factors using a bioinformatic approach.
title: Transcript Interview SIBDARIAH 02 (H2020 OPERAS-P)
Creators: name: Nury, Elisa
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Innovation
subject: OPERAS
subject: H2020 OPERAS-P
subject: Models
subject: Scholarly writing
subject: WP 6.5
subject: Evaluation
subject: WP 6.6
subject: GDPR

description: This interview has been performed by Elisa Nury for the WP 6.5 of the H2020 project OPERAS-P, at DH+, SIB, DARIAH partner. Male interviewee, age 40-49, Switzerland, researcher/manager.
description: Provenance: DH+, SIB (Lausanne, CH)
Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma
Creators: name: Bedal, Konstanze B.
name: Grässel, Susanne
name: Oefner, Peter J.
name: Reinders, Jörg
name: Reichert, Torsten E.
name: Bauer, Richard
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: NEAR-TERM NEWBORNS; HEALTHY TERM; NEONATAL JAUNDICE; BILIRUBIN; HYPERBILIRUBINEMIA; KERNICTERUS; OXYGENATION; ANTIOXIDANT; MANAGEMENT; APOPTOSIS;
subject: 610 Medizin

description: Collagen XVI belongs to the family of fibril-associated collagens with interrupted triple helices (FACIT). It is overexpressed during the progression of oral squamous cell carcinoma (OSCC). The present data show a strong collagen XVI-dependent induction of MMP9 and an increase in OSCC cell invasion. We found activated integrin-linked kinase (ILK) in a complex with kindlin-1 and activation of protein kinase B (PKB/Akt) to be responsible for MMP9 induction. Inhibition of the formation of focal adhesions reduced MMP9 expression. Moreover, collagen XVI overexpressing OSCC cell clones (COLXVI cell clones) transfected with vectors containing different MMP9 promoter fragments adjacent to a luciferase reporter revealed an increase in luciferase signal dependent on AP-1 binding sites. Deletion of the AP-1 binding site 98 bp upstream of the reported transcription start site and inhibition of AP-1 with Tanshinone IIA resulted in decreased MMP9 expression. The AP-1 subunit JunB showed differential expression between COLXVI cell clones and mock control cells. Additionally, mass spectrometric analysis of immunoprecipitates revealed that c-Fos interacted strongly with dyskerin in COLXVI cell clones compared to mock controls.
Claeys, Karel: Die Bibel bestätigt das Weltbild der Naturwissenschaft
Creators: name: Grunert, Erich
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 30 (1989): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 30
Simaetha Thorell 1881
Creators: name: Wang, Cheng
name: Mi, Xiaoqi
name: Li, Shuqiang
name: Xu, Xiang
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Simaetha

description: GenusSimaethaThorell, 1881
Type species.
Simaetha thoracica Thorell, 1881; type locality Australia.
Comments.
The genus was assigned by Maddison (2015) in the subtribe Simaethina Simon, 1903 within the tribe Viciriini Simon, 1901, and is represented by 23 nominal species, mainly distributed from South Asia to Australia (WSC 2024). Although a detailed revision of Oceanian species has been done by Żabka (1994), the genus remains poorly studied because nearly half (11) of the species are known only from a single sex, and four species cannot be precisely identified due to lack of diagnostic drawings (WSC 2024).
description: Published as part of Wang, Cheng, Mi, Xiaoqi, Li, Shuqiang & Xu, Xiang, 2024, Taxonomic notes of jumping spiders (Araneae, Salticidae) from Guangxi, Hainan, Sichuan, Xizang and Yunnan, China, pp. 205-277 in ZooKeys 1221 on pages 205-277, DOI: 10.3897/zookeys.1221.135640
Pericoma estrelica Wagner & Andrade & Gonçalves 2022, sp. nov.
Creators: name: Wagner, Rüdiger
name: Andrade, Rui
name: Gonçalves, Ana
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Pericoma
Pericoma estrelica

description: Pericoma estrelica sp. nov.
Figure 21–22
Diagnose. A very small Pericoma species of the P. diversa -group; thorax and wings without characteristics; gonostyli markedly thinner in distal half; epandrial appendages with 5 tenacula.
Material: 1♂, holotype, Guarda, Seia, Vide e Cabeça (Parque Natural da Serra da Estrela), 40°19’02.96”N, 7°43’54.11”W, 430m a.s.l., 4 September 2014, leg. A. Gonçalves.
Description: Head with eye bridge of four facet rows, three rows in the middle of the eye extension, distance between eyes four facet diameters, interocular suture wide U-shaped. Antenna with scape rectangular, pedicel globular, shorter than scape. Relative length of scape, pedicel and seven flagellomeres: 17–19–16–14–14–14–14–14– 13– distal flagellomeres missing; absolute length: 0.09–0.10–0.08–0.07–0.07–0.07–0.07–0.07–0.07– mm. palpus with four segments, apical segment likely flexible; relative length: 25–28–32– apical segment missing; absolute length: 0.13–0.14–0.16–mm.
Wing length 1.58 mm, width 0.57 mm. Length by width 2.79.
Abdomen with epandrium slightly longer than wide with round corners, a pair of openings at about center. Epandrial appendages elongate, slightly curved with 5 tenacula. Hypandrium uniformly thin along entire length. Gonocoxite tubular, two times longer than wide, with 1 long seta on inner side at about middle; gonostyli 1.5 times longer than gonocoxites, slightly bent, markedly thinner in distal half. Ventral bridge between gonocoxites with two short lobes. Ejaculatory apodeme as long as aedeagus, straight, aedeagus of two parallel sclerites.
Etymology: The species is named after the site of collection, Serra da Estrela.
Comment: The new species is a member of the Pericoma diversa -group and is most similar to P. granadica Vaillant. However, it is smaller and the shape of the gonostyli is different; they are equally bent in P. granadica but clearly narrower in the distal half in P. estrelica sp. nov.
description: Published as part of Wagner, Rüdiger, Andrade, Rui & Gonçalves, Ana, 2022, Moth flies (Diptera, Psychodidae) from Portugal with descriptions of a new genus new species and additions to the fauna of the Iberian Peninsula, pp. 37-59 in Zootaxa 5129 (1) on page 50, DOI: 10.11646/zootaxa.5129.1.2, http://zenodo.org/record/6488081
Elachista tuberella Sruoga 2008
Creators: name: Kaila, Lauri
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Elachistidae
Elachista
Elachista tuberella

description: Elachista tuberella Sruoga, 2008
Elachista tuberella Sruoga, 2008: 62. Type locality: Nepal, Kathmandu, Kakani (Sruoga 2008: 62). Holotype ♂, in NHMUK.
Subgenus: Elachista; freyerella species group.
Distribution: Palearctic. Nepal.
Larval host plant(s): unknown.
Figs.: Sruoga (2008).
description: Published as part of Kaila, Lauri, 2019, An annotated catalogue of Elachistinae of the World (Lepidoptera: Gelechioidea: Elachistidae), pp. 1-231 in Zootaxa 4632 (1) on page 135, DOI: 10.11646/zootaxa.4632.1.1, http://zenodo.org/record/3335414
In vitro Endothelialization and Platelet Adhesion on Titaniferous Upgraded Polyether and Polycarbonate Polyurethanes
Creators: name: Lehle, Karla
name: Li, Jing
name: Zimmermann, Hangörg
name: Hartmann, Björn
name: Wehner, Daniel
name: Schmid, Thomas
name: Schmid, Christof
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: HARD-SEGMENT CHEMISTRY; HUMAN VASCULAR CELLS; TITANIUM; BIOCOMPATIBILITY; STABILITY; STRESS; TITANIUMCARBOXONITRIDE; BIOMATERIALS; EXPRESSION; RESISTANCE; endothelial cell seeding; cytocompatibility; haemocompatibility; platelet adhesion; cardiovascular tissue engineering; titanium
subject: 610 Medizin

description: Polycarbonateurethanes (PCU) and polyetherurethanes (PEU) are used for medical devices, however their bio- and haemocompatibility is limited. In this study, the effect of titaniferous upgrading of different polyurethanes on the bio-and haemocompatibility was investigated by endothelial cell (EC) adhesion/proliferation and platelet adhesion (scanning electron microscopy), respectively. There was no EC adhesion/proliferation and only minor platelet adhesion on upgraded and pure PCU (Desmopan). PEUs (Texin 985, Tecothane 1085, Elastollan 1180A) differed in their cyto-and haemocompatibility. While EC adhesion depended on the type of PEU, any proliferative activity was inhibited. Additional titaniferous upgrading of PEU induced EC proliferation and increased metabolic activity. However, adherent ECs were significantly activated. While Texin was highly thrombotic, only small amounts of platelets adhered onto Tecothane and Elastollan. Additional titaniferous upgrading reduced thrombogenicity of Texin, preserved haemocompatibility of Elastollan, and increased platelet activation/aggregation on Tecothane. In conclusion, none of the PUs was cytocompatible; only titaniferous upgrading allowed EC proliferation and metabolism on PEUs. Haemocompatibility depended on the type of PU.
Xiphocentron (Antillotrichia) Banks 1941
Creators: name: Vilarino, Albane
name: Calor, Adolfo R.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Xiphocentronidae
Xiphocentron

description: SubgenusXiphocentron(Antillotrichia) Banks, 1941: 401
Type species.
Antillotrichia cubana Banks, 1941, original designation. — Flint 1964: 25 [to synonymy]. — Botosaneanu 1988: 221 [resurrected as a valid subgenus].
description: Published as part of Vilarino, Albane & Calor, Adolfo R., 2024, Comparative geometric morphometrics of male genitalia in Xiphocentron subgenera (Trichoptera: Xiphocentronidae): new species, revision and phylogenetic systematics of the subgenus Sphagocentron, pp. 407-431 in Arthropod Systematics & amp; Phylogeny 82 on pages 407-431, DOI: 10.3897/asp.82.e112587
Pericoma (Pachypericoma) blandula Eaton 1893
Creators: name: Wagner, Rüdiger
name: Andrade, Rui
name: Gonçalves, Ana
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Pericoma
Pericoma blandula

description: Pericoma (Pachypericoma) blandula Eaton
Material: 1♂, Porto, Valongo, Campo e Sobrado, 18 March 2011; 1♂, ibidem 12 May 2011; 1♂, ibidem, 13 June 2012; 2♂ Viseu, Tabuaço, Granja do Tedo, 27 April 2014; 1♂, Santarém, Tomar, Paialvo, 3 August 2013.
description: Published as part of Wagner, Rüdiger, Andrade, Rui & Gonçalves, Ana, 2022, Moth flies (Diptera, Psychodidae) from Portugal with descriptions of a new genus new species and additions to the fauna of the Iberian Peninsula, pp. 37-59 in Zootaxa 5129 (1) on page 50, DOI: 10.11646/zootaxa.5129.1.2, http://zenodo.org/record/6488081
Solar mean motion (calendrical)_Tabule Magne_7286C by Husson (Matthieu) (2022) | Type-A (ID n° 477)
Creators: name: Husson, Matthieu
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Astronomy
History of astronomy
DISHAS
Astronomical table

description: This is a type A edition: A type-A edition corresponds to the edition of a table witness originating from a single primary source:
 scribal errors are reproduced.
You can find it on the DISHAS project website from this link: https://dishas.obspm.fr/table-edition/477
description: Source: Medius motus solis‪ (1300–1400) ; Paris, Bibliotheque nationale de France | Latin 7286C , 11v-23r ; Tabule Magne‪ (1325) [John of Lignères (1290–1350)]
Stertinius Simon 1890
Creators: name: Wang, Cheng
name: Mi, Xiaoqi
name: Li, Shuqiang
name: Xu, Xiang
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Stertinius

description: GenusStertiniusSimon, 1890
Type species.
Stertinius dentichelis Simon, 1890; type locality Mariana Is.
Comments.
Stertinius, is considered a member of Simaethina (Maddison 2015). Currently, 16 species have been placed in this genus, primarily from east and southeast Asia (WSC 2024). The genus is poorly defined because the generotype is lacking essential diagnostic drawings, and most of its species were assigned to the genus based only on the similarity to some of the known congeners (Wang et al. 2024).
description: Published as part of Wang, Cheng, Mi, Xiaoqi, Li, Shuqiang & Xu, Xiang, 2024, Taxonomic notes of jumping spiders (Araneae, Salticidae) from Guangxi, Hainan, Sichuan, Xizang and Yunnan, China, pp. 205-277 in ZooKeys 1221 on pages 205-277, DOI: 10.3897/zookeys.1221.135640
No high level evidence to support the use of oral H1 antihistamines as monotherapy for eczema: a summary of a Cochrane systematic review
Creators: name: Zuuren, Esther J. van
name: Apfelbacher, Christian J.
name: Fedorowicz, Zbys
name: Jupiter, Aldrin
name: Matterne, Uwe
name: Weisshaar, Elke
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Cochrane review; eczema; H1 antihistamines; evidence based medicine
subject: 610 Medizin

description: Background

The most important symptom as well as one of the major diagnostic criteria for eczema is itch. Although oral antihistamines continue to be prescribed for people with eczema, it is unclear if they are effective and safe in relieving itch and skin lesions. We sought to evaluate the available evidence on effectiveness of oral antihistamines (H1 antagonists) as monotherapy in children and adults with eczema.
Methods

Searches included 10 databases and trial registers as well as conference proceedings (January 2014). Randomised controlled trials that assessed the effects of oral H1 antihistamines as monotherapy in children and adults with eczema were included.
Results

Our searches retrieved 757 references, but no randomised controlled trial met our inclusion criteria. Most studies allowed concomitant treatments, making the assessment of the individual effects of oral H1 antihistamines impossible.
Conclusions

There is currently no high-level evidence to support or refute the efficacy or safety of oral H1 antihistamines used as monotherapy for eczema. A further review of studies that assesses the effects of oral H1 antihistamines as ‘add-on’ therapy together with concomitant treatments is warranted to determine the beneficial effects of this group of medications in the treatment of eczema.
Post-Trial Access in Latin America : Perceptions of Research Ethics Committee Members
Creators: name: Hellmann, Fernando
Publisher: name: Zenodo
Year: 2025

description: This presentation analyzes how Research Ethics Committee (REC) members perceive post-trial access (PTA) to experimental treatments in Latin America. During the study, 45 in-depth interviewswere conducted and 2 focus groups with REC members from six Latin American countries: Brazil, Argentina Colombia, Mexico, Peru, and Costa Rica. A thematic analysis was used to identify key challenges, practices, and potential solutions regarding PTA.
title: Rapport de voyage, Flandre (1952) : Ligne de New York, 1955, voyage n°24
Creators: name: Bodard, Georges
name: Lejeune, Jacques
name: Normand, Georges
name: Vincelet, Louis
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Journaux de bord
subject: Compagnie Générale Transatlantique
subject: Transports maritimes - Histoire
subject: Marine marchande

description: Chapitrage : Rapport d'inspecteurs - Rapport général / du capitaine - Rapport du commissaire - Rapport du second - Rapport de l'officier de sécurité - Rapport de l'officier de navigation - Rapport du médecin - Rapport contentieux
description: Source: French Lines & Compagnies, 1997 004 4989-30
description: Coverage: 1955-07-18/1955-08-03