cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Foretinib can overcome common on-target resistance mutations after capmatinib/tepotinib treatment in NSCLCs with MET exon 14 skipping mutation
Creators: name: Fujino, Toshio
name: Suda, Kenichi
name: Koga, Takamasa
name: Hamada, Akira
name: Ohara, Shuta
name: Chiba, Masato
name: Shimoji, Masaki
name: Takemoto, Toshiki
name: Soh, Junichi
name: Mitsudomi, Tetsuya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 1: Table S1. A list of tyrosine kinase inhibitors used in this study. Table S2. A list of antibodies used in this study. Table S3. Results of drug screening other than tyrosine kinase inhibitors. Table S4. Type II MET-TKIs evaluated in this study. Table S5. Clinical information of two phase I studies of foretinib. Table S6. Clinical information of five phase II studies of foretinib.
Additional file 1 of Implementing OECD GLP principles for the evaluation of novel vector control tools: a case study with two novel LLINs, SafeNet® and SafeNet NF®
Creators: name: Azizi, Salum
name: Snetselaar, Janneke
name: Kaaya, Robert
name: Matowo, Johnson
name: Onen, Hudson
name: Shayo, Magreth
name: Kisengwa, Ezekia
name: Tilya, Evod
name: Manunda, Baltazari
name: Mawa, Benson
name: Mosha, Franklin
name: Kirby, Matthew
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Infographic.
IUCLID 6.7 test dossiers
Creators: name: EFSA
Publisher: name: Zenodo
Year: 2024
Subjects: IUCLID
IUCLID for pesticides
EU PPP
Test dossiers
IUCLID Test dossiers

description: As part of the deliverables of the negotiated procedure NP/EFSA/TS/2022/03 on “IUCLID Test dossiers” a number of test dossiers were delivered to EFSA to be used in the context of IUCLID for pesticides.

The following datasets are being shared in case they are useful for testing/training purposes. They do not contain confidential data and are considered complete with respect to IUCLID 6 v.7, they may need to be updated for submission in subsequent IUCLID releases.

The available datasets are the following:

·         AS - Pesticide active substance

·         MO – microorganism

·         MRL case 1 - MRL dossier submitted AFTER the active substance approval/renewal

·         MRL case 2 – MRL dossier submitted for a NOT APPROVED active substance

·         MRL case 3 – MRL dossier submitted AS PART OF the active substance approval/renewal

·         MRL case 4 - MRL dossier to delete maximum residue level(s)

·         BS – basic substance

The above datasets can be downloaded, uploaded to an IUCLID instance and edited (the legal entity must be changed!).

Whereas EFSA is happy to make these datasets available to stakeholders, we will not be in a position to provide any support on their upload/download/editing, etc.
description: EU; en; i6z; fdp@efsa.europa.eu
Friendship in emerging adulthood: exploring friendship quality as a mediator between gratitude and interpersonal appreciation and life satisfaction.
Creators: name: Martinez-Carter, Hongmarie
Publisher: name: No Publisher Supplied
Year: 2020

description: The current study explored friendship among the emerging adult population by investigating two aspects of appreciation from Adler & Fagley’s (2005) appreciation model, gratitude and interpersonal appreciation, and their relations with friendship quality and life satisfaction. Both aspects of appreciation are related to enhanced social connections, including romantic relationships (e.g., Gordon et. al, 2012) and friendships (e.g., Lambert & Fincham, 2011). In addition, high quality friendships are associated with well-being (e.g., Demir & Wetekamp, 2007; Raboteg-Saric, & Sakic, 2013). Thus, the primary purpose of the research was to determine if friendship quality could potentially mediate the relationship between either of the aspects and life satisfaction while controlling for gender and the Big Five personality factors. Participants (N = 357) were undergraduate students at Rutgers University who completed an anonymous online survey. All partial correlations (controlling for gender and personality) were significant. Gratitude was positively associated with friendship quality (partial r = .315, p < .001), as was interpersonal appreciation (partial r = .194, p < .001). Gratitude was positively related to life satisfaction (partial r = .132, p < .05), as was interpersonal appreciation (partial r = .126, p < .05). Friendship quality was also positively related to life satisfaction (partial r = .143, p
Additional file 2 of Foretinib can overcome common on-target resistance mutations after capmatinib/tepotinib treatment in NSCLCs with MET exon 14 skipping mutation
Creators: name: Fujino, Toshio
name: Suda, Kenichi
name: Koga, Takamasa
name: Hamada, Akira
name: Ohara, Shuta
name: Chiba, Masato
name: Shimoji, Masaki
name: Takemoto, Toshiki
name: Soh, Junichi
name: Mitsudomi, Tetsuya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 2: Fig. S1. Drug screening against MET D1228A/Y using a drug library. Fig. S2. Summary of growth inhibitory curves of eight MET-TKIs for Ba/F3 cells with each MET mutation. Fig. S3. Evaluation of the effects of secondary mutations on sensitivity to MET-TKIs using the Hs746t cell line. Fig. S4. Analysis of the secondary resistance mutations against 1st line foretinib. Fig. S5. Growth inhibition curves for ENU-derived foretinib resistant Ba/F3 cells carrying MET secondary mutation. Fig. S6. Comparison of the structures of each type II MET-TKI. Fig. S7. Summary of growth inhibitory curves of three MET-TKIs for Ba/F3 cells with MET tertiary mutations. Fig. S8. Structure of MET in the DFG-in and DFG-out conformations.
Additional file 1 of Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice
Creators: name: Hwang, Yeonggwang
name: Kim, Hyoung-Chun
name: Shin, Eun-Joo
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 1. Additional Information and Additional Tables S1–S5.
Additional file 1 of A randomized controlled trial of customized adherence enhancement (CAE-E): study protocol for a hybrid effectiveness-implementation project
Creators: name: Levin, Jennifer B.
name: Briggs, Farren
name: Blixen, Carol
name: Bauer, Mark
name: Einstadter, Douglas
name: Albert, Jeffrey M.
name: Weise, Celeste
name: Woods, Nicole
name: Fuentes-Casiano, Edna
name: Cassidy, Kristin A.
name: Rentsch, Julie
name: Sarna, Kaylee
name: Sajatovic, Martha
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1.
title: Dagstuhl Reports, Table of Contents, Volume 13, Issue 12, 2023
Creators: name: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
Publisher: name: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
Year: 2024
Subjects: subject: Table of Contents
subject: Frontmatter

description: Dagstuhl Reports, Table of Contents, Volume 13, Issue 12, 2023
description: DagRep, Volume 13, Issue 12, pages i-ii
Additional file 2 of Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice
Creators: name: Hwang, Yeonggwang
name: Kim, Hyoung-Chun
name: Shin, Eun-Joo
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 2. Additional Figures S1–S5.
Additional file 1 of Evaluation of the value of conventional and unconventional lipid parameters for predicting the risk of diabetes in a non-diabetic population
Creators: name: Sheng, Guotai
name: Kuang, Maobin
name: Yang, Ruijuan
name: Zhong, Yanjia
name: Zhang, Shuhua
name: Zou, Yang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Text S1. STROBE Statement—checklist of items that should be included in reports of observational studies.
Additional file 2 of A randomized controlled trial of customized adherence enhancement (CAE-E): study protocol for a hybrid effectiveness-implementation project
Creators: name: Levin, Jennifer B.
name: Briggs, Farren
name: Blixen, Carol
name: Bauer, Mark
name: Einstadter, Douglas
name: Albert, Jeffrey M.
name: Weise, Celeste
name: Woods, Nicole
name: Fuentes-Casiano, Edna
name: Cassidy, Kristin A.
name: Rentsch, Julie
name: Sarna, Kaylee
name: Sajatovic, Martha
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 2.
Additional file 2 of Evaluation of the value of conventional and unconventional lipid parameters for predicting the risk of diabetes in a non-diabetic population
Creators: name: Sheng, Guotai
name: Kuang, Maobin
name: Yang, Ruijuan
name: Zhong, Yanjia
name: Zhang, Shuhua
name: Zou, Yang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Figure S1. Proportional hazards assumption checking. Figure S2. A RCS evaluates the best threshold of HDL-C for predicting future diabetes risk. B RCS evaluates the best threshold of TG for predicting future diabetes risk. C RCS evaluates the best threshold of RC for predicting future diabetes risk. D RCS evaluates the best threshold of TC/HDL-C ratio for predicting future diabetes risk. E RCS evaluates the best threshold of TG/HDL-C ratio for predicting future diabetes risk. F RCS evaluates the best threshold of LDL/HDL-C ratio for predicting future diabetes risk. G RCS evaluates the best threshold of non-HDL/HDL-C ratio for predicting future diabetes risk. H RCS evaluates the best threshold of RC/HDL-C ratio for predicting future diabetes risk.
Current Treatment Trends in T2DM and Impact of COVID-19 among T2DM Patients: A Review
Creators: name: Dr. Ashish Akshay Bedi
name: Bhatt, Anjali
name: Vibhor Aggarwal
name: Mohd. Tousib
Publisher: name: figshare
Year: 2020
Subjects: subject: 111503 Clinical Pharmacy and Pharmacy Practice
subject: FOS: Clinical medicine
subject: 111502 Clinical Pharmacology and Therapeutics

description: Diabetes does not come alone; it comes with a number of co
existing illnesses which includes blindness, kidney failure, heart
disease and neuropathy. They may share similar risk factors or
may be a complication of it. The therapy given to these patients
and the goal of this therapy is to control the blood sugar level. It
is personalized for the individual patient on the basis of his
body’s demand and other co-existing illnesses. According to
WHO, Diabetes is one of the leading cause of death all over the
world. Changing lifestyle of people in developing countries like
India has tremendously increased the statistical figure of
chronic diseases like diabetes mellitus.The motive behind the
DUE studies is to optimize the therapy and promote appropriate
use of drugs up to the standards in the hospital setting. Despite
of so many anti-diabetic agents in the market, metformin is still
recommended as first choice of drug in the treatment. The most
common combinational therapy given to diabetics was
glimepiride and metformin. The physician’s decision lies on
various factors like the Pharmaceutical resources, cost of the
medicine, his personal attribute, physiological state of the
patient and many more. Various newer agents are being
developed by the pharmaceutical companies for more efficient
treatment in different situations. The newer agents include
Teneligliptin, Linagliptin, Exenatide, etc. Regular treatment is
the key feature related to the effectiveness of the therapy in the
patients. But an eye should be kept on the ADRs from these
medications for more safety data. For example if metformin
was used in a dose of more than 1000mg/day it results in
Metformin-induced dyspepsia. For the estimation of risk
factors to ensure maximum benefits of the treatment,
assessment of ADR is important. In COVID-19 infection,
diabetic patients are at risk for their hospitalization and
mortality. The challenge is the treatment of hyperglycemia
during infection and the infections further leads to loss of
glycemic control. More frequent monitoring of blood glucose
level and continuous alteration in the therapy as per the
requirements should be done.
(Forschungs-) Software Zitierfähig Machen
Creators: name: Druskat, Stephan
Publisher: name: Zenodo
Year: 2018
Subjects: software citation, citation file format

description: Poster presented at "Fakultätstag Forschungsdaten der sprach- und literaturwissenschaftlichen Fakultät der Humboldt-Universität zu Berlin", 16 February 2018.

(Faculty day on research data)
Additional file 3 of Evaluation of the value of conventional and unconventional lipid parameters for predicting the risk of diabetes in a non-diabetic population
Creators: name: Sheng, Guotai
name: Kuang, Maobin
name: Yang, Ruijuan
name: Zhong, Yanjia
name: Zhang, Shuhua
name: Zou, Yang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3: Table S1. Pearson correlation analysis of baseline conventional and unconventional lipid parameters and METS-IR. Table S2. Collinearity diagnostics steps.
Additional file 1 of Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis
Creators: name: Hesse, Christina
name: Beneke, Valerie
name: Konzok, Sebastian
name: Diefenbach, Claudia
name: Bülow Sand, Jannie Marie
name: Rønnow, Sarah Rank
name: Karsdal, Morten Asser
name: Jonigk, Danny
name: Sewald, Katherina
name: Braun, Armin
name: Leeming, Diana Julie
name: Wollin, Lutz
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. No detectable increase in LDH in the culture supernatant of human PCLS after antifibrotic treatment.
A death worth dying: a survey of the roles and practices of psychologists working in end-of-life care
Creators: name: Miodownik, Alec
Publisher: name: No Publisher Supplied
Year: 2020

description: As individuals approach end-of-life, they and their families and other caregivers may be especially vulnerable to experiencing psychosocial stressors that can negatively affect psychological wellbeing. A growing body of evidence suggests that there are numerous benefits to providing psychosocial care to all these individuals as they confront end-of-life care and end-of-life. Importantly, clinical psychologists are qualified for, well suited to, and add value to such end-of-life psychosocial care. They can intervene before the onset of illness; after an illness is diagnosed and treatment has been initiated; during advanced illness and the dying process; and after the death of the patient with grieving family and survivors. Despite the ways that clinical psychologists are particularly well-equipped to engage professionally with end-of-life care, they are still relatively rare members of and not generally perceived of as central to end-of-life care treatment teams. In light of this professional gap highlighting clinical psychologists' absence in end-of-life care, the present study seeks (a) to document the valuable roles, practices, and functions of clinical psychologists now actually working in end-of-life care settings, and (b) to understand the ways in which these professionals cultivate meaning in this highly stressful work to sustain themselves. Towards this end, in this dissertation, I first provide a review of the current literature describing psychology's relationship with death and dying, psychology's role at end-of-life, psychosocial treatment at end-of-life, and meaning-making. Then, I describe the qualitative study methodology I used to conduct semi-structured interviews with clinical psychologists now practicing in end-of-life care settings to capture the range and depth of the participants' relevant experiences. The interviews were both (a) analyzed individually as narrative case studies in order to identify the variety of practices and experiences among the subjects; and (b) compared and contrasted with each other to highlight common themes found across individual cases. I end with a discussion of the implications of this study, including directions for future research and implications for clinical practice.
ZRO₂ and UO₂ dissolution by molten Zircalloy
Creators: name: Stuckert, J.
name: Miassoedov, A.
name: Hayward, P.J.
name: Hofmann, P.
name: Veshchunov, M.
Publisher: name: Karlsruhe
Year: 2002

description: This paper describes the results of the different tests on the dissolution of ZrO2 and UO2 by molten Zircaloy at temperatures about 1000 K below their melting point. The understanding of the mechanisms of this process is important for the modelling of the fuel rod failure during the reactor severe accidents.
Additional file 1 of Assessing cardiovascular parameters and risk factors in physical therapy practice: findings from a cross-sectional national survey and implication for clinical practice
Creators: name: Faletra, Agostino
name: Bellin, Giuseppe
name: Dunning, James
name: Fernández-de-las-Peñas, César
name: Pellicciari, Leonardo
name: Brindisino, Fabrizio
name: Galeno, Erasmo
name: Rossettini, Giacomo
name: Maselli, Filippo
name: Severin, Richard
name: Mourad, Firas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Survey developed based on recent scientific publications and adapted to the Italian socio-economic and cultural context.
Additional file 1 of Detection of low-load Epstein-Barr virus in blood samples by enriched recombinase aided amplification assay
Creators: name: Li, Jing-yi
name: Chen, Xiao-ping
name: Tie, Yan-qing
name: Sun, Xiu-li
name: Zhang, Rui-qing
name: He, An-na
name: Nie, Ming-zhu
name: Fan, Guo-hao
name: Li, Feng-yu
name: Tian, Feng-yu
name: Shen, Xin-xin
name: Feng, Zhi-shan
name: Ma, Xue-jun
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Additional file 1: Table S1. The EBV-positive patients’ disease information. Table S2. The disease information for 330 EBV-negative patients without EBV infection. Table S3. Time-to-positivity for 61 samples. Table S4. Results of EBV analysis using traditional RAA versus traditional qPCR detection kits. Table S5. Results of EBV analysis using the RAA assay versus the qPCR assay following M1 bead enrichment.
Improving translation of behavior analytic jargon from English to Spanish
Creators: name: Odom, Jaye
Publisher: name: No Publisher Supplied
Year: 2020

description: Healthcare professionals are legally obligated to provide interpretation services to people with limited English-speaking proficiency (Chen, Youdelman, & Brooks, 2007). While interpretation services certainly aid in communication between people who speak different languages, the task becomes more complicated when an additional specialized vocabulary is utilized, such as healthcare terminology that is not considered everyday language. For example, in the field of autism treatment, interpreters may be asked to translate terms within applied behavior analysis (ABA). Current literature has demonstrated that interpreters make frequent errors related to specialized vocabulary that can significantly impact treatment (Anazawa, Ishkawa, & Kiuchi, 2012; Baker, Hayes, & Fortier, 1998; Flores et al., 2003; Searight & Searight, 2009). However, there has been little investigation into methods to improve interpretation. The few studies that do exist suggest time-consuming and expensive interventions (Acosta & Christo, 1982; Beeber, Lewis, Cooper, Maxwell, & Sandelowski, 2009; Bergunde & Pollabauer, 2019). The present study aimed to assess the effectiveness of a brief, low-cost intervention to improve the accuracy of translation of ABA terminology, or jargon, from English to Spanish. Three participants were asked to translate vignettes that included ten ABA terms, before and after they were provided with a brief Spanish glossary of ABA terms. Results indicated that the intervention significantly improved participants’ interpretation accuracy. The results of this study address current gaps in the literature and provide an alternative to current interventions that may potentially be effective with both professional and ad hoc interpreters.
Identifying Prognostic Factors for Well-Differentiated Metastatic Pancreatic Neuroendocrine Tumours: A Retrospective International Multicentre Cohort Study
Creators: name: Jiménez-Fonseca, Paula
name: Krug, Sebastian
name: Tamagno, Gianluca
name: Fierro Maya, Felipe
name: Monléon Getino, Antonio
name: Rodriguez Casado, Clara Isabel
name: Costa, Frederico
name: Herder, Wouter W. De
name: Jann, Henning
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Biomarkers
subject: Cohort study
subject: Multivariate analysis
subject: Overall survival
subject: Pancreatic neuroendocrine tumours
subject: Prognostic factors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Pancreatic neuroendocrine tumours (pNETs) represent rare neoplasms of all NETs often presenting without functional activity. Many sporadic non-functioning pNET patients are already metastatic at the time of diagnosis, and the therapeutic approach to such patients is mostly palliative. In this international, multicentre, retrospective cohort study, we assessed the prognostic value of a set of anthropometric, clinical, biochemical, radiological and pathological parameters at baseline and the impact of the therapeutic strategies on the survival of patients with sporadic grade 1/2, stage IV, non-functioning pNETs. Three hundred and twelve consecutive patients diagnosed between 1993 and 2010 were included. The median overall survival (OS) was 6.6 years and survival at 5 and 10 years was 62 and 34% respectively. On univariate analysis, Eastern Cooperative Oncology Group (ECOG) status > 2, grade 2, bilobar hepatic metastases, synchronous metastases, and high chromogranin A, alkalinephosphatase and lactic-dehydrogenase were associated with a significant reduction of OS. Palliative/curative surgery and loco-regional hepatic interventions were significant factors improving OS. On multivariate analysis, ECOG status >= 2, synchronous metastases, Ki-67 >= 10%, and high alkalinephosphatase correlated significantly with an increased risk of death. Both palliative/curative surgery and loco-regional hepatic interventions had a positive impact on OS. Although most parameters did not prove to be independent OS predictors at multivariate analysis, they showed a tendency towards that. Future prospective studies including larger patient populations may give greater clarity. We believe the integration of these parameters has the potential to provide a reliable prognostic score for the stratification of patients with sporadic well-differentiated metastatic non-functioning pNETs.
Application of Photoacoustic Methods and Confocal Microscopy for Monitoring of Therapeutic Response in Plaque Psoriasis
Creators: name: Ossadnik, Katharina
name: Philipp, Sandra
name: Bost, Wolfgang
name: Fournelle, Marc
name: Richter, Heike
name: Lademann, Jürgen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Photoacoustic techniques
subject: Confocal laser scanning microscopy
subject: Psoriasis
subject: Capillaries
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Psoriasis is prone to relapses and requires long-term therapy that may induce a range of adverse effects; therefore, an efficient and early detection of relapses is desirable. In this study, photoacoustic imaging and confocal laser scanning microscopic (CLSM) methods were investigated for their suitability in psoriasis follow-up examinations. Using a high-resolution photoacoustic system, the vascular structures of 11 psoriatic patients and 6 healthy volunteers were investigated. No differences were detected with respect to the average vessel diameter and vasculature per unit volume in the tissue of healthy volunteers and non-lesional and lesional skin areas of psoriatic patients. By means of CLSM, the diameters of the dermal papillae of 6 volunteers and 6 psoriatic patients were determined. The diameters of the dermal papillae of the healthy volunteers (0.074 +/- 0.006 mm) revealed no significant difference when compared to non-lesional skin areas of psoriatic patients (0.079 +/- 0.005 mm). The results obtained for the lesions in psoriatic patients showed a significant difference (Wilcoxon test, p = 0.028) between the diameters of the dermal papillae of the lesional skin areas 0.114 +/- 0.012 mm) and the non-lesional skin areas (0.079 +/- 0.005 mm). Thus, CLSM can be applied for monitoring psoriasis follow-up examinations.
Additional file 1 of Malaria mosquitoes acquire and allocate cattle urine to enhance life history traits
Creators: name: Dawit, Mengistu
name: Hill, Sharon R.
name: Birgersson, Göran
name: Tekie, Habte
name: Ignell, Rickard
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Species, sex and gonotrophic state of the mosquitoes captured in CDC light traps baited with the synthetic odour blend of 24 h aged cattle urine or heptane control. Table S2. Synthetic compounds used for electrophysiological and behavioural analyses. Fig S1. Blood-fed Anopheles arabiensis display no oviposition preference for the headspace volatile extracts of fresh and aged cattle urine. Letter designations indicate no significant difference from one another (one-way analysis of variance with a Tukey’s post hoc analysis; p > 0.05). Error bars indicate the standard error of the proportion. Fig. S2. Behavioural responses of host-seeking (A) and blood-fed (B) Anopheles arabiensis to the full and subtractive synthetic blends of 24 h aged cattle urine. The removal of single components from the synthetic blend (open circles) differentially and significantly affected the response of the females from both physiological states. Different lowercase letters indicate significant differences as determined by a one-way analysis of variance followed by a Dunnett’s post hoc analysis (p < 0.05). Error bars represent the standard error of proportion. Fig. S3. Cattle urine enhances host decoy trap catches only in the presence of the host cue, heat. Host decoy traps only caught malaria mosquitoes in a deserted pasture between the breeding site and the village in the presence of both heat and cattle urine (fresh or aged), but not either alone. Error bars indicate the standard error of the mean.
Inguinal Lymph Node Metastasis of a Primary Serous Papillary Carcinoma of the Peritoneum One Year after CRS and HIPEC
Creators: name: Katou, Shadi
name: Feist, Mathilde
name: Raue, Wieland
name: Pratschke, Johann
name: Rau, Beate
name: Brandl, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Primary peritoneal serous papillary carcinoma
subject: Inguinal lymph node metastasis
subject: Cytoreductive surgery
subject: Hyperthermic intraperitoneal chemotherapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Primary peritoneal serous papillary carcinoma is a rare malignant epithelial tumor which was first described in 1959. Peritoneal serous papillary carcinoma arises from the peritoneal epithelium and originates from a single or multicentric focus of the peritoneum involving the peritoneum of the abdomen and pelvis. The involvement of retroperitoneal lymph nodes occurs in 64% of the patients diagnosed with this malignancy. So far, there is no report about inguinal lymph node metastasis in this disease. Case Report: We present a rare case of a 63-year-old female patient who developed singular inguinal lymph node metastasis 1 year after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy due to peritoneal serous papillary carcinoma. The lymph node metastasis was found by computed tomography (CT) scan and was resected and histologically confirmed. The postoperative course was uneventful, and the patient was discharged on postoperative day 1. The last CT scan 24 months after initial cytoreduction and 12 months after lymph node resection showed no further tumor recurrence. Conclusion: This case report should raise the awareness of potentially unexpected presentation of extraperitoneal metastasis and highlights the importance of patient follow-up including clinical examination and CT scans of thorax/abdomen/pelvis following a systematic schedule.
Laser Scanning Microscopic Investigations of the Decontamination of Soot Nanoparticles from the Skin
Creators: name: Lademann, Jürgen
name: Knorr, Fanny
name: Patzelt, Alexa
name: Meinke, Martina C.
name: Richter, Heike
name: Krutmann, Jean
name: Rühl, Eckart
name: Doucet, Olivier
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Skin
subject: Nanoparticles
subject: Decontamination
subject: Ex vivo testing
subject: Laser scanning microscopy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background/Aims: Airborne pollutants, such as nano-sized soot particles, are increasingly being released into the environment as a result of growing population densities and industrialization. They can absorb organic and metal compounds with potential biological activity, such as polycyclic aromatic hydrocarbons and airborne pollen allergens. Local and systemic toxicities may be induced in the skin if the particulates release their harmful components upon dermal contact. Methods: In the present study, skin pretreatments with serum and/or shield as barrier formulations prior to exposure and washing with a cleanser subsequent to exposure were evaluated as a protection and decontamination strategy using laser scanning microscopy. Results: The results indicate that while the application of serum and a cleanser was insufficient for decontamination, the pretreatment with shield prior to nanoparticle exposure followed by washing led to the removal of a considerable amount of the carbon black particles. The combined application of serum and shield before the administration of carbon black particles and subsequent washing led to their elimination from the skin samples. Conclusion: The application of barrier-enhancing formulations in combination with a cleanser may reduce the penetration of harmful airborne particulates by preventing their adhesion to the skin and facilitating their removal by subsequent washing with the cleanser.
Additional file 2 of Assessing cardiovascular parameters and risk factors in physical therapy practice: findings from a cross-sectional national survey and implication for clinical practice
Creators: name: Faletra, Agostino
name: Bellin, Giuseppe
name: Dunning, James
name: Fernández-de-las-Peñas, César
name: Pellicciari, Leonardo
name: Brindisino, Fabrizio
name: Galeno, Erasmo
name: Rossettini, Giacomo
name: Maselli, Filippo
name: Severin, Richard
name: Mourad, Firas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 2. Results of the non-parametric test to identify any significant difference in responses between subgroups of the sample.
Phenotypic Variability in Autosomal Dominant Familial Alzheimer Disease due to the S170F Mutation of Presenilin-1
Creators: name: Tiedt, Hannes O.
name: Benjamin, Beate
name: Niedeggen, Michael
name: Lueschow, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Alzheimer disease
subject: Early-onset Alzheimer disease
subject: Familial Alzheimer disease
subject: Presenilin-1
subject: PSEN1 protein, human
subject: Cerebellar ataxia
subject: Hereditary diseases
subject: Neurodegenerative disease
subject: Neuropsychology
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In rare cases, patients with Alzheimer disease (AD) present at an early age and with a family history suggestive of an autosomal dominant mode of inheritance. Mutations of the presenilin-1 (PSEN1) gene are the most common causes of dementia in these patients. Early-onset and particularly familial AD patients frequently present with variable non-amnestic cognitive symptoms such as visual, language or behavioural changes as well as non-cognitive, e.g. motor, symptoms. Objective: To investigate the phenotypic variability in carriers of the PSEN1 S170F mutation. Methods: We report a family with 4 patients carrying the S170F mutation of whom 2 underwent detailed clinical examinations. We discuss our current findings in the context of previously reported S170F cases. Results: The clinical phenotype was consistent regarding initial memory impairment and early onset in the late twenties found in all S170F patients. There were frequent non-amnestic cognitive changes and, at early stages of the disease, indications of a more pronounced disturbance of visuospatial abilities as compared to face and object recognition. Non-cognitive symptoms most often included myoclonus and cerebellar ataxia. A review of the available case reports indicates some phenotypic variability associated with the S170F mutation including different constellations of symptoms such as parkinsonism and delusions. Conclusion: The variable clinical findings associated with the S170F mutation highlight the relevance of atypical phenotypes in the context of research and under a clinical perspective. CSF sampling and detection of Ap species may be essential to indicate AD pathology in unclear cases presenting with cognitive and motor symptoms at a younger age.
Additional file 1 of The Centres for Disease Control light trap (CDC-LT) and the human decoy trap (HDT) compared to the human landing catch (HLC) for measuring Anopheles biting in rural Tanzania
Creators: name: Namango, Isaac Haggai
name: Marshall, Carly
name: Saddler, Adam
name: Ross, Amanda
name: Kaftan, David
name: Tenywa, Frank
name: Makungwa, Noely
name: Odufuwa, Olukayode G.
name: Ligema, Godfrey
name: Ngonyani, Hassan
name: Matanila, Isaya
name: Bharmal, Jameel
name: Moore, Jason
name: Moore, Sarah J.
name: Hetzel, Manuel W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Additional tables.
Additional file 3 of Assessing cardiovascular parameters and risk factors in physical therapy practice: findings from a cross-sectional national survey and implication for clinical practice
Creators: name: Faletra, Agostino
name: Bellin, Giuseppe
name: Dunning, James
name: Fernández-de-las-Peñas, César
name: Pellicciari, Leonardo
name: Brindisino, Fabrizio
name: Galeno, Erasmo
name: Rossettini, Giacomo
name: Maselli, Filippo
name: Severin, Richard
name: Mourad, Firas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 3. Blood pressure screening in physiotherapy practice.
Additional file 1 of Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity
Creators: name: Karlsson, Jesper
name: Wetterö, Jonas
name: Weiner, Maria
name: Rönnelid, Johan
name: Fernandez-Botran, Rafael
name: Sjöwall, Christopher
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Supplementary Figure 1. Comparisons of pentameric C-reactive protein (pCRP) (A–D), monomeric (m)CRP (E–H), and mCRP/pCRP ratio (I–L) in 160 patients with systemic lupus erythematosus with lupus nephritis vs. no nephritis (A, E, I), normal vs. subnormal estimated glomerular filtration rate (eGFR) (B, F, J), presence vs. absence of hematuria (C, G, K) and presence vs. absence of albuminuria (D, H, L). Abnormal eGFR <60 mL/min/1.73m2. (* = p≤0.05).
Additional file 4 of Assessing cardiovascular parameters and risk factors in physical therapy practice: findings from a cross-sectional national survey and implication for clinical practice
Creators: name: Faletra, Agostino
name: Bellin, Giuseppe
name: Dunning, James
name: Fernández-de-las-Peñas, César
name: Pellicciari, Leonardo
name: Brindisino, Fabrizio
name: Galeno, Erasmo
name: Rossettini, Giacomo
name: Maselli, Filippo
name: Severin, Richard
name: Mourad, Firas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 4. Blood pressure screening during exercise in physiotherapy practice.
Additional file 2 of Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity
Creators: name: Karlsson, Jesper
name: Wetterö, Jonas
name: Weiner, Maria
name: Rönnelid, Johan
name: Fernandez-Botran, Rafael
name: Sjöwall, Christopher
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Supplementary Figure 2. Comparisons of pentameric C-reactive protein (pCRP) (A–C), monomeric (m)CRP (D–F), and mCRP/pCRP ratio (G–I) demonstrated between normal vs. subnormal estimated glomerular filtration rate (eGFR) (A, D, G), presence vs. absence of hematuria (B, E, H) and presence vs. absence albuminuria (C, F, I) in patients with ANCA-associated vasculitis. Abnormal eGFR <60 mL/min/1.73m2. (* = p≤0.05).
Additional file 3 of Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity
Creators: name: Karlsson, Jesper
name: Wetterö, Jonas
name: Weiner, Maria
name: Rönnelid, Johan
name: Fernandez-Botran, Rafael
name: Sjöwall, Christopher
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Supplementary Figure 3. Standard curves and reactivity of the monoclonal detection antibody 8C10 towards monomeric C-reactive protein (mCRP) and pentameric (p)CRP: (A) standard curve for 8C10 antibody with mCRP; (B) reactivity of 8C10 antibody with pCRP; and (C) standard curve for samples in the present study.
Additional file 5 of Assessing cardiovascular parameters and risk factors in physical therapy practice: findings from a cross-sectional national survey and implication for clinical practice
Creators: name: Faletra, Agostino
name: Bellin, Giuseppe
name: Dunning, James
name: Fernández-de-las-Peñas, César
name: Pellicciari, Leonardo
name: Brindisino, Fabrizio
name: Galeno, Erasmo
name: Rossettini, Giacomo
name: Maselli, Filippo
name: Severin, Richard
name: Mourad, Firas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 5. Decision tool for early identification of potential cardiovascular adverse event.
Evaluation of the New Lateral Flow Card MDmulticard® Basic Extended Phenotype in Routine Clinical Practice
Creators: name: Mayer, Beate
name: Müller, Julia
name: Candela-García, María-José
name: Manteau, Annie-Claude
name: Weinstock, Christof
name: Pruß, Axel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Duffy antigen
subject: Kidd antigen
subject: Ss antigens
subject: MDmulticard
subject: Lateral flow technology
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Transfusion emergencies and critical situations require specifically designed devices to simplify and optimize the standard procedures. In addition, matching antigens over and above ABO-Rh-K would be beneficial. Methods: Routine blood samples were collected in four immunohematology centers and tested with the new MDmulticard Basic Extended Phenotype for the simultaneous detection of the Duffy, Kidd, and Ss antigens, according to the principle of the lateral flow. Results were compared with those obtained using routine serology methods. Discrepancies were analyzed by molecular techniques/genotyping. Results: 310 samples were tested (167 donors; 75 patients; 28 subjects with positive direct antiglobulin test (DAT); 15 newborns; 25 previously transfused patients). The 285 samples with non-mixed-field reaction yielded 1,710 antigen results with 8 discrepancies (0.47%) six of which in DAT-positive subjects: three false-positive (Fy(a)) for MDmulticard, and two false-positive (Fy(a)) plus three false-negative (Fy(b)) for the reference methods (MDmulticard PPA for donors/patients/newborns: 99.82%; negative percent agreement: 100%; sensitivity: 100%; specificity: 99.39%, positive predictive value: 99.75%; negative predictive value: 100%). The MDmulticard detected mixed-field in 15 antigen reactions from 13 transfused patients, undetected by the comparative method, with the opposite result in 8 antigens (5 patients). Conclusion: The MDmulticard Basic Extended Phenotype met the criteria prescribed for the testing of donor, patient, DAT-positive, and newborn samples in transfusion laboratory routine.
Ruptured myocardial infarction
Creators: name: Lloret Del Hoyo, Juan
Publisher: name: EURORAD
Year: 2018
Subjects: subject: Cardiac
subject: CT
subject: CT-Angiography
subject: Catheter arteriography
subject: Echocardiography
subject: Diagnostic procedure
subject: Arteriosclerosis
subject: Ischaemia / Infarction

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 78 years
description: Clinical History: 78 year-old patient with obesity and DM-II presented to the Emergency Room with a history of 24 hours of chest pain. EKG showed STEMI (Fig. 1) and the patient presented with severe hypotension. Final Diagnosis: Ruptured myocardial infarction.
Physiological and Molecular Effects of in vivo and ex vivo Mild Skin Barrier Disruption
Creators: name: Pfannes, Eva K. B.
name: Weiss, Lina
name: Hadam, Sabrina
name: Gonnet, Jessica
name: Combardière, Béhazine
name: Blume-Peytavi, Ulrike
name: Vogt, Annika
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Skin barrier
subject: Cyanoacrylate skin surface stripping
subject: Transcutaneous vaccination
subject: Particle penetration
subject: Tape stripping
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used. We previously described cyanoacrylate skin surface stripping as an efficient method to open hair follicles, enhance particle penetration, and activate Langerhans cells. We conducted ex vivo and in vivo measurements on human skin to characterize the biological effect and quantify barrier disruption-related inflammation on a molecular level. Despite the known immunostimulatory effects, this barrier disruption and hair follicle opening method was well accepted and did not result in lasting changes of skin physiological parameters, cytokine production, or clinical side effects. Only in ex vivo human skin did we find a discrete increase in IP-10, TGF-β, IL-8, and GM-CSF mRNA. The data underline the safety profile of this method and demonstrate that the procedure per se does not cause substantial inflammation or skin damage, which is also of interest when applied to non-invasive sampling of biomarkers in clinical trials.
Additional file 1 of Psychosocial barriers and facilitators for adherence to a healthy lifestyle among patients with chronic kidney disease: a focus group study
Creators: name: Cardol, Cinderella K.
name: Boslooper-Meulenbelt, Karin
name: van Middendorp, Henriët
name: Meuleman, Yvette
name: Evers, Andrea W. M.
name: van Dijk, Sandra
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.