title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÑ Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼ Ð´Ð»Ñ Ð±Ð¸Ð¾Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¾Ð¹ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ð¸ Ð¸ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ð¸ÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð²ÑÑÐ²Ð¾Ð±Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development and research of polymersomal hybrid systems for biomedical engineering and controlled drug release
Creators: name: ÐÐµÐºÑÐ°ÑÐµÐ²Ð¸Ñ, ÐÐ°Ð²ÐµÐ»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¼Ð¸ÐºÑÐ¾ÐºÐ°Ð¿ÑÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÐºÐ¾Ð°ÐºÑÐ¸Ð°Ð»ÑÐ½Ð¾Ðµ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑÐ¾Ð¼Ñ
Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ
Ð°Ð´ÑÐµÑÐ½Ð°Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ°
ÐºÐ¾Ð½ÑÑÐ¾Ð»Ð¸ÑÑÐµÐ¼Ð¾Ðµ Ð²ÑÑÐ²Ð¾Ð±Ð¾Ð¶Ð´ÐµÐ½Ð¸Ðµ
Ð±Ð¸Ð¾Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ°Ñ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ñ
ÑÐµÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð²Ð½Ð°Ñ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ð°
microencapsulation
coaxial electroforming
polymersomal systems
hybrid systems
target drug delivery
controlled release
biomedical engineering
reconstructive medicine

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description: Biomedical materials science and systems engineering for personalized medicine occupies one of the leading positions in the field of science and research in modern medicine. The main direction of this development is the formation of polymersomal hybrid nano-and micro-sized systems based on biocompatible and / or biodegradable materials, encapsulation of biological active compounds in their volume, as well as programming of their final properties due to the introduction of modifying agents. The problems of this direction are the development of effective methods for the synthesis of starting materials, modifying agents and other components to create hybrid carrier systems with the function of the controlled release of biologically active compounds (including therapeutic substances) into the focus of inflammation of soft tissues and epidermal layers. Solving the existing problem will increase the therapeutic effect of various BAC-groups, the action of which is aimed at the preventive effect on various groups of pathogenic microorganisms, as well as reducing the regeneration time. Using the methods of forming polymersomal hybrid systems by the method of coaxial electrohydrodynamic molding, a laboratory-experimental device was developed, with which fibrous and spherical BACâs with an encapsulated antibacterial polypeptide complex from a cationic polypeptide a, b-defensin, a polycyclic nisin peptide, and also a substance possessing a property of accelerating the proliferation of cells - DE panthenol. As a result of the studies, the surface of the surgical thread was modified using spherical ASGs with an encapsulated polypeptide complex. Due to the modification and the fluometric "Live / Dead" analysis on strains of E.coli and S.aureus, the effectiveness of using these structures with the property of controlled release and the provision of a preventive antibacterial effect was proved. Also, using fibrous ASGs with encapsulated DE panthenol, a promising material was created for creating a filament of a surgical thread with a regenerating effect. Efficiency was shown as a result of an in vitro experiment on a cell culture of fibroblasts, which, due to the influence of DE panthenol, increased the proliferation rate.