cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CCWI2017: F113 'Online Water-Quality Monitoring based on Pattern Analysis'
Creators: name: Page, Rebecca M.
name: Waldmann, Daniel
name: Gahr, Achim
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: To date, drinking water quality monitoring frequently relies on a threshold-based approach coupled with occasional manual sampling for reference analysis and as evidence for legal requirements concerning the water quality. However, the increased availability of online measurements provides a good basis for an adaptive approach to high-resolution monitoring of water quality. In this case study, patterns in water quality of limestone springs were identified using multivariate analysis and artificial neural networks. Self-organizing maps were used to calculate system states based on six online parameters (spring discharge, turbidity, pH, el. conductivity and spectral absorption at 254 nm). A non-linear Sammon projection highlighted the relationship between the different system states, rendering a basis for the quantification of change occurring during the observation period in December 2015 - January 2016. The multivariate approach highlighted different phases during an event based on the relative location in a scatter plot and on the xy distance between two system states based on consecutive measurements. As this approach does not require the definition of thresholds and considers actual changes in system state, it is applicable to complex systems and adaptive management strategies.
Unternehmensverantwortung im Informationszeitalter
Creators: name: Bendel, Oliver
Publisher: name: Netzmedien
Year: 2015
Subjects: subject: 330 - Wirtschaft

description: IT-Unternehmen tragen Verantwortung und müssen Verantwortung übernehmen. Die Begriffe von Wirtschafts- und Informationsethik helfen dabei, die Herausforderungen zu erkennen und zu beschreiben. Denn die Frage, was Corporate Social Responsibility ist, muss im Informationszeitalter neu beantwortet werden.
A toolkit for personal health resources at the workplace
Creators: name: Schulte, Volker
name: Verkuil, Arie Hans
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2015
Subjects: subject: SME
subject: Health Management
subject: Healthy lifestyles
subject: 650 - Management

description: Strengthening personal health resources is an important aspect of "Health promotion at the workplace’’. Workplace Health Promotion (WHP) is the combined effort of employers, employees and society to improve the health and well-being of people at work. This can be achieved through a combination of improving the work organization and the working environment, promoting active participation, and encouraging personal development. The question is how employers can best provide access to high quality tools and blended learning programmes which enhance workers’ health behaviors. While acknowledging the individual’s responsibility for his or her own health, this set of activities focuses on the role of the environment and the managers or employers. The attention here is on the organization and design of work in both its physical and psychosocial dimensions. Our task is to identify, prioritize and validate those instruments, which are most appropriate for specific cultures, environments and technologies as guided by the principles of the WHO healthy workplace model. The connection between the physical and psychosocial environments is influenced by high level management choices and decisions about how work will be organised. The psychosocial environment is essential for a health promotion climate. Consequently, the workplace is seen primarily as a venue through which various health promotion programmes can be delivered. Supportive management climate refers to organizing work in ways that promote rather than defeat health of employees. This means maximizing the degree to which employees participate in the governance of their own work (including the maintenance of a physically safe environment), and providing adequate recognition and acknowledgment for good work. In this way, management will communicate their serious intention to create those working conditions that lies in the focus of the connection between the organization of work and health. WHP consists of policies based on programmes, projects or instruments such as questionnaires, guidelines and information materials, programmes on the prevention of addictive drugs (such as alcohol abuse, smoking), the promotion of healthy eating habits, opportunities for physical activity, addressing mental health and stress, promoting family friendly working conditions and providing diversity training programmes.
CCWI2017: F11 'Can a Valve Closure Transient Cause Mobilisation of Adhered Particles?'
Creators: name: Collins, Richard
name: Weston, Sally
name: Boxall, Joseph
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Dynamic forces induced by hydraulic transients are traditionally associated with structural consequences, however attention should also be given to water quality implications. Conceptually the dynamic forces due to hydraulic transients could mobilise adhered particles and release hazardous material into the bulk water, potentially causing public health and economic problems. This paper presents a set of controlled and systematic experiments that conclusively prove, for the first time, the ability of valve closure transients to mobilise an adhered particle where steady state conditions cannot. This is a significant finding as there is a net decrease in flow, hence pseudo steady state shear stresses, yet the dynamic forces are greater than the initial conditions. Future work will aim to deepen this new understanding of the impact of transients on water quality in Drinking Water Distribution Systems.
Studies of the ovarian tumour suppressor protein OPCML with a view to determining its structure and understanding its role in modulating RTK signalling
Creators: name: Zanini, Elisa
Publisher: name: Imperial College London
Year: 2013

description: The opioid-binding cell adhesion molecule (OPCML) is a glycosylphosphatidylinositol (GPI) anchored protein that was found to be epigenetically inactivated in 83% of ovarian cancers and demonstrated to act as a tumour suppressor gene (TSG), inhibiting tumour cell growth in vitro and severely attenuating tumourigenesis in vivo (Sellar et al., 2003). We subsequently showed that OPCML exerted its suppressor functions by negatively regulating a spectrum of receptor tyrosine kinases (RTKs), such as ErbB2/HER2, FGFR1 and EphA2, attenuating their downstream signalling (McKie et al., 2012). Initial in vitro interaction studies revealed that OPCML physically interacted with this defined group of RTKs as a prerequisite for their downregulation. The aims of this PhD project were to define key interacting regions between OPCML and the extracellular domains of the target RTKs, to work towards elucidating the structure of OPCML and to investigate the therapeutic potential of a recombinant form of OPCML. Here it is described how a comprehensive panel of OPCML constructs was created and how these constructs were utilised for GST- and His-tagged OPCML protein production in E.coli (BL21(DE3)) and insect cells (Sf21). Selected His-tag constructs were used for expression and purification of the protein to attempt initial crystallisation studies. Tagged OPCML proteins were utilised to investigate RTK interacting partners of OPCML from members of the EGFR and FGFR families by pull-down assays initially. We then developed in-house mammalian 2-hybrid expertise in order to investigate in detail the interacting regions between OPCML and members of the EGFR, FGFR and Eph families, identifying regions of the receptors critical for the interaction with OPCML upon creating deletion constructs of their extracellular domain. We identified the importance of the distal Ig domain of OPCML to RTK interaction by virtue of our analysis of a previously identified somatic missense mutation in a primary ovarian tumour, a C–G transversion at nucleotide position 334 resulting in amino acid substitution (P95R) within the first Ig domain (Sellar et al 2003). Expression of the OPCMLP95R elicits clear disruption of cell adhesion phenotypes, in addition to disrupting the interaction of OPCML with EphA2. The FGFR1 interaction with OPCML has appeared more robust compared to the other RTK examples studied and a more precise deletion of specific FGFR1 amino acid motifs is required for loss of interaction to be observed. A His-tagged OPCML was used for the treatment of cancer cells in vitro and of two intraperitoneal models in vivo, demonstrating that exogenous administration of the recombinant protein caused profound anti-tumorigenic effects in several ovarian cancer cell lines as well as in the intraperitoneal models of EOC in mice.
Monocyte dimethylarginine dimethylaminohydrolase 2 is regulated by pathological stress and plays a critical role in the immune response to sepsis
Creators: name: Lambden, Simon
Publisher: name: Imperial College London
Year: 2015

description: Background: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase (NOS) and regulates the synthesis of nitric oxide (NO) in vivo. ADMA is metabolised by the enzymes dimethylarginine dimethylaminohydrolase 1 and 2 (DDAH 1 and 2), which have differing tissue distributions, with DDAH2 the only isoform found in immune cells. These studies tested the hypothesis that DDAH2 plays an important role in regulating the immune response to infection by modulating ADMA concentrations. Methods: In order to test this hypothesis, a series of experiments explored the regulation of murine and human monocyte DDAH2 in response to pathophysiological stressors. The impact of global and macrophage-specific DDAH2 knockout on the haemodynamic and immune response to sepsis and the resulting association with mortality was determined using transgenic animal models. Finally, the role of DDAH2 in human septic shock was determined by analysing plasma and DNA from patients enrolled in a randomised controlled trial of vasopressor therapy. Results: In isolated monocytes, DDAH2 was found to be regulated by both Interferon-γ and hypoxia, leading to reduced intracellular ADMA concentrations and exaggerated NO synthesis by immune cells. Both global and macrophage-specific knockout of DDAH2 led to significant impairment of immune cell function and increased mortality following caecal ligation and puncture in animal models. Increased plasma ADMA and SDMA levels were shown to be associated with risk of death in 215 patients with septic shock. However, when data were corrected for methylarginine clearance, ADMA was also found to play a protective role. In this population, the DDAH2 single nucleotide polymorphism rs805305 was associated with improved survival and increased ADMA:SDMA ratio. Conclusions: Considered as a whole, these data demonstrate that DDAH2 plays an important role in regulating the immune response to sepsis and the risk of death in human septic shock.
title: Navigating seventeenth-century Venetian Art History
title: Language, Place, and Alchemy in Marco Boschini’s “La Carta del Navegar Pitoresco”
titleType: Subtitle
Creators: name: Struhal, Eva
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Kunstgeschichte
subject: Venedig
subject: 17. Jahrhundert
subject: Marco Boschini
subject: 700 Künste und Unterhaltung::750 Malerei::750 Malerei, Gemälde
subject: 400 Sprache::450 Italienisch, Rumänisch, Rätoromanisch::457 Varianten des Italienischen

description: This Working Paper analyzes the literary and art historical choices made by Marco Boschini (1602–1681) in Carta del Navegar Pitoresco (Venice, 1660). It places the author and his work in the cultural context of the two eminent Venetian learned academies with which he was affiliated, namely the Accademia Delfica and the Accademia de’ Incogniti. A painter, engraver, cartographer, and producer of glass pearls, Boschini embodied the hybrid intellectual culture associated with such institutions in seventeenth-century Italy. Among other things, this culture was reflected in his decision to write the Carta in the Venetian vernacular and to engage with disciplines such as literature and alchemy. The work therefore provides an ideal vehicle for investigating the influence of learned academies on early modern intellectual culture.
CCWI2017: F149 'WATER NETWORK CHARACTERISATION BASED ON MASS BALANCE WITH REGARDS TO DISCOLOURATION RISK USING HIGH FREQUENCY TURBIDITY MONITORING'
Creators: name: Starczewska, Dagmara
name: Gaffney, John
name: Boult, Stephen
name: Mounce, Stephen
name: Boxall, Joseph
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Water companies are currently facing the challenge to continue the supply of high quality drinking water while at the same time trying to meet ever increasing regulatory standards. Despite a high standard of water quality monitoring at both water treatment plants and major supply mains, many water companies continue to use customers as water quality monitors in their distribution networks. This paper presents the assessment of particulate transport in water distribution systems over short and long-duration monitoring (years) by the application of the latest technology for continuous and remote monitoring of turbidity. Turbidity was monitored at 15 minute resolution at 2 sites in a District Meter Area (DMA) with historical evidence of discolouration problems. Monitoring at this resolution demonstrates its necessity to determine whether and when there is a discolouration problem and how it responds to remediation. Also, demonstrated is the utility of calculating high resolution mass flux from turbidity as an aid to predicting discolouration. Multi-year monitoring at a single site in the DMA has given a unique insight into discolouration processes and the impact of remediation.
Perinatal mental disorders in Switzerland: prevalence estimates and use of mental-health services
Creators: name: Berger, Anke
name: Bachmann, Nicole
name: Signorell, Andri
name: Erdin, Rebekka
name: Oelhafen, Stephan
name: Reich, Oliver
name: Cignacco, Eva
Publisher: name: EMH Schweizerischer Ärzteverlag
Year: 2017
Subjects: subject: Perinatal mental disorders
subject: 300 - Sozialwissenschaften

description: BACKGROUND Perinatal mental disorders (PMDs) are the most common complication of pregnancy and the first postpartum year. Since PMD prevalence and use of mental-health services by perinatal women in Switzerland are unknown, we analysed existing health statistics. METHODS We used statistics from a large health insurance company, hospitals and freelance midwives. We assessed the annual rates of mental healthcare use in perinatal women (n = 13 969). We ascertained the annual rates of PMD treatment in obstetric inpatients (n = 89 699), and annual rates of PMD records by freelance midwives (n = 57 951). In 15 104 women who gave birth in 2012 or 2013, we assessed use of mental-healthcare before and during pregnancy, and in the postpartum year. For the same sample, we determined proportions of medication and consultation treatments. We used multiple regression analysis to estimate the influence of PMD on overall healthcare costs of mandatory health insurance. RESULTS The annual rate of mental-healthcare use by perinatal women was 16.7%. The annual rate of PMD treatment in obstetric inpatients was 1.1%. The annual rate of PMD records in the midwifery care setting was 2.9%. Women with PMD use mental health services mainly in non-obstetric outpatient settings. Medication was the most frequent treatment. Primary care providers and mental health specialists contributed almost equally to consultation treatments. PMD during pregnancy raised overall costs of healthcare in the postpartum year by 1214 Swiss francs.
Gehörlos: Leben und Wohnen im Alter. Erste Einblicke in ein laufendes Forschungsprojekt
Creators: name: Girard, Simone
name: Kohn, Johanna
Publisher: name: Stiftung Schweizer Zentrum für Heil- und Sonderpädagogik
Year: 2021
Subjects: Gehörlosigkeit
Alter
Selbstbestimmung
Doppelte Diskriminierung

description: Der Anteil an Menschen mit einer Hörbeeinträchtigung nimmt mit fortschreitendem Alter zu. In diesem Beitrag geht es im Besonderen um Menschen, die bereits als Kleinkinder oder vor Abschluss des Lautspracherwerbs gehörlos wurden. Der Artikel 19 der UN-Behindertenrechtskonvention fordert Massnahmen, damit Menschen mit Behinderungen selbstbestimmt leben können; insbesondere in Bezug auf das Wohnen. In diesem Beitrag wird eine laufende Studie vorgestellt, welche die Situation von gehörlosen Personen im Alter erörtert und den Handlungsbedarf hinsichtlich der unabhängigen Lebensführung aufzeigt. In den Interviews hat sich bisher herausgestellt, dass der Kontakt sowohl zu gehörlosen als auch zu hörenden Menschen für alle Befragten ein wesentliches Qualitätsmerkmal von geeigneten Wohnformen im Alter ist. Der Zugang zu altersrelevanten Informationen im Sinne der UN-Behindertenrechtskonvention ist noch nicht gewährleistet.
SPHINX Automated Cybersecurity Certification v1
Creators: name: Karagiannis, Stylianos
Publisher: name: Zenodo
Year: 2020
Subjects: Cybersecurity certification
Auditing
Vulnerability Assessment

description: The SPHINX Automated Cybersecurity Certification (ACC) enables a solution for conducting automated and continuous cybersecurity certification on systems and software components. Using existing cybersecurity frameworks and guidelines such as ISO27001, ISO27701, HIPAA, GDPR, NIST800-53 and by following the EU Cybersecurity Certification Framework, this component aspires to provide auditing accordingly to certify newly entering components on systems that could maintain various security risks. The auditing process is the core process and includes a set of rulesets which depicts the existing cybersecurity guidelines, policies and frameworks related to auditing processes. This document presents the detailed design for the SPHINX ACC component, following the component’s introduction in the SPHINX architecture deliverable (D2.6 - SPHINX Architecture v2). It extends the details and the cybersecurity framework, policies and guidelines which the certification process will follow as well as technical aspects and the key aspects which are included to the component.
WorkAnywhere: Mehr Produktivität und Zufriedenheit der Mitarbeitenden sowie Entlastung der Verkehrsinfrastruktur dank mobil-flexibler Arbeitsformen
Creators: name: Weichbrodt, Johann
name: Sprenger, Martin
name: Steffen, Martin H.
name: Tanner, Alexandra
name: Meissner, Jens
name: Schulze, Hartmut
Publisher: name: SBB AG & Swisscom AG
Year: 2013
Subjects: subject: mobil-flexible Arbeit
subject: Hauptverkehrszeiten
subject: 150 - Psychologie
subject: 330 - Wirtschaft

description: Kann flexibles Arbeiten die Pendlerspitzen reduzieren und gleichzeitig zu mehr Produktivität und Zufriedenheit führen? Untersucht wurden in diesem Forschungsprojekt die Auswirkungen von flexiblem Arbeiten auf Verkehr, Arbeitszufriedenheit, Teamzusammenarbeit und Produktivität, sowie Kultur und Führung. Dafür machten Mitarbeitende von SBB und Swisscom einen zweimonatigen Selbstversuch. Die Teilnehmenden konnten Arbeitsflexibilität und -mobilität so einsetzen, dass 65% ihrer Fahrtzeiten ausserhalb der Hauptverkehrszeiten lagen. Ausserdem berichteten sie von gesteigerter Produktivität und Zufriedenheit. Das schweizweite Potenzial der neuen Arbeitsweise zur Entlastung des ÖV zu den Hauptverkehrszeiten wird unter realisierbaren Bedingungen auf 7 Prozent geschätzt.
Additional file 4 of Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
Creators: name: Andersson, Peder
name: Johnsson, Jesper
name: Björnsson, Ola
name: Cronberg, Tobias
name: Hassager, Christian
name: Zetterberg, Henrik
name: Stammet, Pascal
name: Undén, Johan
name: Kjaergaard, Jesper
name: Friberg, Hans
name: Blennow, Kaj
name: Lilja, Gisela
name: Wise, Matt P.
name: Dankiewicz, Josef
name: Nielsen, Niklas
name: Frigyesi, Attila
Publisher: name: figshare
Year: 2021
Subjects: Space Science
Cell Biology
Biotechnology
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Additional file 4: Table 1B. Day 1–24 hours of ICU treatment.
CCWI2017: F6 'Optimal positioning of water quality sensors in water distribution networks: comparison of numerical and experimental results'
Creators: name: Piazza, Stefania
name: Mariacrocetta Sambito
name: Feo, Roberto
name: Freni, Gabriele
name: Puleo, Valeria
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: In the water distribution networks, a deliberate or accidental contamination causes loss of water quality; the implementation of a real-time sensor network is essential to promptly detect the event of contamination. To achieve the optimum positioning of the probes, to reduce the cost of the instrumentation and maintenance, and obtaining, at the same time, a reliable monitoring of the system, optimization techniques are widely applied. In the present study, a numerical optimisation approach was compared with the results of an experimental campaign. The optimization problem is formulated in accordance with literature state- of-the-art, using the genetic algorithm NSGA-II coupled with a hydraulic simulator. The results were tested and verified using a looped laboratory distribution network, equipped with a real-time monitoring water quality system, which allows to run contamination experiments in a controlled environment.
Application of Bayesian hierarchical models for the analysis of complex clinical trials: an analysis strategy based on two case studies in dental research
Creators: name: Gonzalez-Maffe, Juan Guillermo
Publisher: name: Imperial College London
Year: 2012

description: Aim: To develop a strategy for the analysis of complex experiments using Bayesian hierarchical models, and demonstrate the advantage of the Bayesian formulation when analysing complex experiments. Methods: There is increased popularity in designing complex experiments; such experiments help amplify the efficiency of clinical research. The Bayesian approach is a natural candidate to tackle complex problems in a straightforward manner as it handles efficiently large amounts of missing data and multivariate responses data. Joint models are formulated in order to deal with missing data and multivariate data. A strategy is developed for the analysis of complex experiments based on two clinical experiments in dentistry. Data: Two clinical experiments in dental research are selected for analysis. In dentistry, we encounter complex experiments as the individual units are the teeth which are clustered within subjects. Results and Conclusion: The results indicate that using Bayesian joint models improve the parameters estimation while taking into account the entire complexity of the study design. The Bayesian formulation gives us the advantages to estimate complex joint models in a straightforward manner. Bayesian joint models can deal with missing data and multivariate data efficiently given the exibility by the MCMC analysis. The joint model propagates the entire uncertainty in the model into the posterior distribution. We can easily extend the model to account for different types of missing data, and/or account for different correlation structures when dealing with multivariate data.
Motive des Kulturpublikums. Was sind die zugrundeliegenden psychologischen Werte, die zu einem Besuch in einem kleinen Kulturraum führen?
Creators: name: Masar, Ivana
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: Kulturkonsum
Kulturraum
Motive
Werte

description: Diese Arbeit geht der Frage nach, welche zugrundeliegenden psychologischen Werte zu einem Besuch in einem kleinen Kulturraum führen. Die sequentielle Verbindung der Attribute, Konsequenzen und Werte eines Kulturbesuches wird anhand von semi-strukturierten eins-zu-eins Interviews mit Anwendung der Ladderingmethode erhoben und ausgewertet. Die Interviews wurden mit sechs Frauen und fünf Männern im Alter zwischen 21 und 49 Jahren durchgeführt. Die Analyse ergab, dass Zugehörigkeitsgefühl, Wissen, warme Beziehungen zu anderen, Gleichberechtigung sowie Gegenseitigkeit die wichtigsten Werte eines Besuches in einem kleinen Kulturraum darstellen. Somit verfolgen Menschen bei diesem spezifischen Kulturkonsum ein soziales Motiv, ein Motiv nach Wissen und ein altruistisches Motiv.
Neo-cleavage Theory and Democratic Backsliding in the European Union
Creators: name: Zabotkin, Mikhail
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Europäische Integration
subject: 300 Sozialwissenschaften::320 Politikwissenschaft::320 Politikwissenschaft

description: This paper analyzes the extent to which neo-cleavage theory can explain democratic backsliding in the European Union, focusing on the role of the GAL/TAN cleavage and an alternative explanation, populism. It brings together different factors into a causal model based on the willingness-opportunity metatheoretical framework, which is then evaluated empirically using the Qualitative Comparative Analysis (QCA). The results indicate that both TAN ideological stance and populism provide two alternative motivations for democratic backsliding, but do not produce backsliding in the absence of certain opportunities.
LARP1, an mRNA binding protein involved in cancer progression & platinum resistance
Creators: name: Abd Latip, Normala
Publisher: name: Imperial College London
Year: 2012

description: LARP1 is a novel protein that was first identified in Drosophila where it was shown to be required for embryogenesis, spermatogenesis and cell cycle progression. LARP1 is ‘La-related protein’ by virtue of its La domain and RRM motif, common to all La proteins. Unlike the other members of LARP family, LARP1 also carries a conserved C terminal domain; the tandem DM15 repeat-containing region which is of unknown function, although it has been proposed to be involved in mRNA binding. LARP1 has been shown previously in our lab to regulate the translation of a subset of mRNAs that encode cytoskeletal proteins, as well as the synthesis of proteins required for invasion such as α-2 catenin, actin-gamma and matrix metalloprotease 14 (MMP-14). Also, LARP1 has been reported to interact with cytoskeletal proteins such as tubulin, keratins, actin, myosin and the cell-cell junction protein, Zona occludens1 (ZO-1) as well as the actin binding proteins: Plectin, Spectrin, Actinin and Tropomyosin and the actin-capping proteins CapZA and CapZB. In this thesis, LARP1 is demonstrated to exist in complexes with both PABP and eIF4E, colocalise within lamellipodia of the cells, and be required for migration. In histological specimens taken from women with normal cervix (normal), pre-invasive cervical intra-epithelial neoplasia (CIN) and invasive squamous cell cancer (SCC), levels of cytoplasmic LARP1 were shown to be elevated from normal to CIN and from CIN to SCC, suggesting an association between levels of cytoplasmic LARP1 and cancer progression. Morphologically, following LARP1 over-expression, there is loss cell-to-cell contact with scattering of cells away from their original clusters. Cells also acquire a spindle-like appearance, and expresscharacteristic ofmesenchymal markers, which suggest LARP1 induces epithelial mesenchymal transition (EMT). LARP1 depletion resensitisesa platinum-resistant ovarian carcinoma cell line to cisplatin treatment. In this study, we show that cells with reduced LARP1 have lower expression of Mre11 but have unaltered DNA damage recognition by γH2AX foci. LARP1 knockdown also alters BRCA2 expression and its subcellular localisation following cisplatin treatment. These findings suggest LARP1 depletion impairs the ability of the cell to efficiently repair cytotoxic DNA damage. In this thesis we show that the RNA-binding protein LARP1 is involved in cell migration, epithelial mesenchymal transition and chemotherapeutic resistance. This supports a role for LARP1 in, cancer progression, and suggests it may act as a promising new therapeutic target in cancer.
title: Data Stewardship Maturity Report for GHRSST Level 3P North Atlantic Regional Subskin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite (GDS version 1.0)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00233
The role of MAF, an androgen regulated transcription factor in prostate cancer
Creators: name: O'Hanlon Brown, Ciara
Publisher: name: Imperial College London
Year: 2012

description: Prostate cancer is a common, relatively asymptomatic tumour which predominantly affects an elderly population. The majority of prostate cancers are Androgen Receptor (AR) positive and demonstrate androgen dependent growth. Androgen deprivation therapy is the cornerstone of prostate cancer treatment. Understanding the androgen response in prostate cancer is thus central to understanding the molecular biology of the disease. Microarray analysis of the androgen response in the LNCaP prostate cancer model has previously identified MAF as the highest ranking transcription factor among genes whose expression is significantly upregulated in response to the synthetic androgen R1881. MAF is a member of the Maf family, a group of leucine zipper transcription factors widely expressed in human tissues. Little is known regarding the role MAF plays in the prostate and in prostate cancer. This project seeks to address this question. The results presented here confirm the androgen regulation of MAF at an mRNA and protein level in LNCaP cells. This regulation has been studied further through analysis of AR transactivation of the MAF promoter. Knockdown of MAF expression using siRNA has an inhibitory effect on the growth of LNCaP cells. Knockdown was also seen to inhibit the expression of a subset of androgen regulated genes. Microarray analysis of gene expression in LNCaP cells was performed follwing siRNA knockdown of MAF expression and has identified a set of genes that may be regulated by MAF in LNCaP cells. Immunohistochemical analysis of a prostate cancer tissue microarray was performed and this demonstrated MAF expression in prostate cancer tissue samples and in normal prostate epithelium. Interestingly it appears that the level of MAF expression in prostate cancers is inversely correlated with increasing Gleason grade. MAF expression appears greatly reduced/absent in metastatic prostate cancers. Taken together, this data highlights MAF as an androgen regulated transcription factor. We propose that MAF plays a role in the down stream propogation of androgen signalling in LNCaP cells. Loss of MAF expression with increasing Gleason grade and in metastatic prostate cancer represents dedifferentiation of prostate cancer epithelial cells with disease progression. It may thus delineate a subset of prostate cancers less likely to respond to androgen deprivation therapy.
Evaluation «Einsatz und Nutzung ausgewählter Informationsprodukte der Strategie Antibiotikaresis-tenzen (StAR)». Schlussbericht im Auftrag des Bundesamtes für Gesundheit (BAG)
Creators: name: Laubereau, Birgit
name: Meyer, Lea
name: Kaufmann, Cornel
name: Visschers, Vivianne
name: Feck, Vanessa
name: Schaffner, Dorothea
Publisher: name: Interface und Hochschule für Angewandte Psychologie FHNW
Year: 2020
Subjects: subject: Antibiotikaresistenzen
subject: Informationskampagne
subject: Patienten
subject: Tierhalter
subject: 150 - Psychologie
subject: 610 - Medizin und Gesundheit
subject: 630 - Landwirtschaft, Veterinärmedizin

description: Die seit 2016 umgesetzte Strategie Antibiotikaresistenzen (StAR) sieht in den Bereichen Mensch (StAR-M) und Tier (StAR-T) unter anderem vor, dass die Zielgruppen (d.h. Patienten/-innen, Kundschaft in Apotheken und Tierhalter/-innen) sensibilisiert und ihr Wissensstand erhöht werden soll. Zu diesem Zweck wurden unter Federführung des Bundesamts für Gesundheit (BAG) und des Bundesamts für Lebensmittelsicherheit und Veterinärwesen (BLV) zusammen mit Vertretern/-innen der Fachverbände verschiedene Informationsprodukte in den Bereichen Mensch («Antibiotika richtig einsetzen») und Tier («Antibiotika retten Leben – sind aber nicht immer nötig») entwickelt. Mittels einer Evaluation wird in den Bereichen Mensch und Tier die Verbreitung, die Akzeptanz sowie den Einsatz der Informationsprodukte durch die Mittler in den Arztpraxen (Grundversorger, Zahnärzte/-innen, Tierärzte/-innen) und Apotheken beurteilt. Zudem wird die Qualität im Sinne von Nutzerfreundlichkeit untersucht. Aufbauend auf den Ergebnissen werden realistische Empfehlungen zuhanden des BAG und des BLV formuliert als Grundlage für den Entscheid, welche Produkte weiterhin genutzt und verbreitet werden sollen und wie diese gegebenenfalls optimiert werden können.
Additional file 3 of Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
Creators: name: Andersson, Peder
name: Johnsson, Jesper
name: Björnsson, Ola
name: Cronberg, Tobias
name: Hassager, Christian
name: Zetterberg, Henrik
name: Stammet, Pascal
name: Undén, Johan
name: Kjaergaard, Jesper
name: Friberg, Hans
name: Blennow, Kaj
name: Lilja, Gisela
name: Wise, Matt P.
name: Dankiewicz, Josef
name: Nielsen, Niklas
name: Frigyesi, Attila
Publisher: name: figshare
Year: 2021
Subjects: Space Science
Cell Biology
Biotechnology
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Additional file 3: Table 1A. Baseline characteristics.
title: Candidature CHIN Luis Antonio Vicente Baptista
Creators: name: Baptista, Luis Antonio Vicente
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Candidature de Luis Antonio Vicente Baptista pour un séjour de recherche, dans le cadre du LabexMed.
CCWI2017: F86 'DISCOLOURATION RISK MANAGEMENT AND CHLORINE WALL DECAY'
Creators: name: Iftekhar Zaman Sunny
name: Husband, Stewart
name: Moore, Graeme
name: Drake, Nick
name: Mckenzie, Kevan
name: Boxall, Joseph
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: This paper explores the concept that periodic imposed excess shear stress events to manage discolouration risk in trunk mains can also impact on the chlorine wall decay by changing the properties of the accumulated pipe wall material. By implementing a series of varying magnitude shear stress events in multiple trunk main demonstrated that significant material was mobilised, thereby cleaning the mains and reducing discolouration risk. Measured chlorine data also suggests that repeated shear stress intervention also reduced the chlorine wall decay relative to a control network and the larger the intervention greater the benefit. Calibrated first order chlorine decay simulations in EPANET supported this finding. The modelling results further show that the wall decay has a dominant influence on this change even for these large diameter pipes. The significance of these findings is to evidence the additional value of regular hydraulics based cleaning interventions for large diameter mains delivering service improvement in terms of both discolouration risk and persistence of chlorine residual.
Home Office und Co-Workingspaces – Ressourcen für Gemeinden?
Creators: name: Schulze, Hartmut
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: subject: Arbeitspsychologie
subject: Mobil-flexible Arbeit
subject: Home-Office
subject: Coworking-Spaces
subject: 100

description: Auf dem Bernischen Gemeindekadertag 2018 in Gwatt beschäftigte sich Prof. Dr. Hartmut Schulze (Hochschule für Angewandte Psychologie FHNW) mit Potenzialen die für Gemeinden aus Home Office und Coworking-Spaces entstehen können. Auf Basis aktueller Erkenntnisse aus angewandten Forschungsprojekten kann abgeleitet werden, dass mobil-flexible Arbeitsweisen zunehmen, Arbeit zunehmend an verschiedenen Orten stattfinden wird und Home Office und Coworking-Spaces sowie das Arbeiten im Zug und von unterwegs zum arbeitsorganisatorischen Standard werden. Das Arbeiten unabhängig von Ort und Zeit bietet für die Mitarbeitenden Potenziale und Risiken, es braucht Schulung sowie eine entsprechende Organisation und Führungskultur. Ergonomiestandards gelten auch für die Kombination von Arbeitsorten, werden aber bisher noch zu wenig berücksichtigt und Coworking-Spaces bieten auch für kleinere Städte und Agglomerationen ein Potenzial für die Attraktivierung.
Exploring the association between circular rural-to-urban labour migration and HIV: a study from north India
Creators: name: Rai, Tanvi
Publisher: name: Imperial College London
Year: 2013

description: Migrant workers are believed to act as a bridge population in the spread of HIV. However, migration patterns are highly variable, influenced by local historical and socio-economic contexts. In India, rural-to-urban, circular migrant workers are a priority group for HIV interventions. Their success requires an understanding of the processes influencing migrant vulnerability and how the migration-HIV relationship evolves over time. I conducted a systematic review examining the association between migration and HIV prevalence. I also analysed behavioural survey data from a study on migrant men to quantify and characterise those at greatest risk. For the case study, I carried out qualitative fieldwork in Allahabad district, an area of high rural-to-urban, circular migration and increasing HIV prevalence. I conducted interviews in two settings: clinical and rural village. I interviewed HIV-positive individuals at an HIV-treatment centre and migrant men and wives of migrants in two high out-migration villages. Published studies showed some association between circular migration and HIV, but migration was defined inconsistently across publications. According to survey data 20% of migrant men had non-spousal sexual partners at multiple locations; this was associated with self-perception of HIV risk, age and recent migrant status. The qualitative case study showed specific factors such as nature of social group and migration location affecting risk of infection. Following infection, migrant status delayed contact with HIV services, depleting household savings on private treatment for HIV-related conditions and facilitating onward transmission. After enrolment with HIV services, diminished health, a rigid ART regime and job insecurity hindered resumption of migration-based livelihoods. Increased HIV risk in migrants is due to the context of migration not mobility itself. Despite free testing and treatment services, migrant workers and their families are being diagnosed late. The risk to migrant livelihoods from HIV has strong implications for long-term ART adherence and prognoses.
Die Bedeutung des Freien Explorierens und Experimentierens für die Selbstbestimmung der Lernenden – eine Erprobung im Sachunterricht der Grundschule
Creators: name: Probst, Michelle Angelina
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Selbstbestimmung
subject: Freies Explorieren und Experimentieren
subject: Motivation
subject: Sachunterricht
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung

description: In Anbetracht der Forderung des Grundschulverbandes an eine zukunftsfähige Schule, dessen Unterricht auf die Erweiterung der Selbst- und Welterfahrung der Lernenden abzielen soll und somit durch vielfältige Lehr- und Lernformen Möglichkeiten zur selbstständigen Auseinandersetzung und Erschließung der Umwelt bieten soll, widmet sich die vorliegende Arbeit dem Konzept des Freien Explorierens und Experimentierens und dessen Bedeutung für die Selbstbestimmung der Lernenden. Die Grundlage zur Determination der Signifikanz der Selbstbestimmung bildet die Self-determinition theory (von Deci und Ryan), welche die Relevanz der Befriedigung der psychologischen Grundbedürfnisse für das Auftreten selbstbestimmter Motivation und die selbstregulierende Entwicklung des individuellen Selbst in den Fokus rückt. Basierend auf dieser Voraussetzung zur Entstehung der Selbstbestimmung wird eine angenommene Wirkungskette aufgestellt, die, ausgehend von der Berücksichtigung und Befriedigung der Grundbedürfnisse der Lernenden, Hinweise auf die motivationale Orientierung der Schüler*innen geben soll und dessen Konsequenzen für das individuelle Selbst abbildet, um die Bedeutung des FEE für die Selbstbestimmung der Lernenden darzustellen.
Temporal Discounting EMA
Creators: name: MacVittie, Alexandra L
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Body Awareness
subject: Ecological Momentary Assessment
subject: Emotional Experience
subject: Mental Health
subject: Temporal Discounting

description: 6 weeks of experience sampling data regarding emotional experience, body awareness, context, and temporal discounting.
Eco-evolutionary responses in a native insect to plant invasion
Creators: name: Geraghty, Dylan Michael
Publisher: name: Macquarie University
Year: 2024
Subjects: classificationCode: 410405
subject: Environmental rehabilitation and restoration

description: Invasive alien species are one of the greatest threats to ecosystems and biodiversity globally. In this study I explored the evolutionary consequences of the invasive balloon vine, Cardiospermum grandiflorum, for the native Australian soapberry bug, Leptocoris tagalicus. My study focussed on L. tagalicus populations sampled on invasive C. grandiflorum and native Alectryon tomentosus, along Australia’s east coast. Field and laboratory observations confirmed that the insect has evolved longer proboscides on its new host plant. My breeding experiments indicated high narrow-sense heritability in proboscis length. Moreover, L. tagalicus enjoys higher fitness on this new host. Despite signals of disruptive selection on L. tagalicus beak length caused by differences in fruit size of invasive and native host plants, my genomic analyses suggested that gene flow is high between insect populations regardless of host plant and that insects can disperse over vast distances. I also identified two ancestral population genetic clusters for L. tagalicus which appear to have admixed recently, perhaps due to the invasion spread of C. grandiflorum. My study shows that shifts in interaction ecologies facilitated by invasive species may not only lead to a breakdown of historical barries of gene flow, but also to rapid evolutionary changes, in native species.
Κίνδυνοι και μελέτη διαχείρισης κινδύνων του ελληνικού τραπεζικού συστήματος
Creators: name: Γκανέτσος, Κωνσταντίνος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Κεφαλαιακή επάρκεια
subject: Δείκτης ρευστότητας
subject: Βασιλεία ΙΙΙ
subject: Εποπτικές απαιτήσεις
subject: Διαχείριση κινδύνων
subject: Τραπεζικό σύστημα

description: Στην παρούσα διπλωματική εργασία εκτίθεται το ζήτημα των τραπεζικών κινδύνων και η διαχείριση αυτών από τα ελληνικά Τραπεζικά Ιδρύματα. Εκκινώντας από τη δομή του Τραπεζικού Συστήματος και μελετώντας τις μεταβολές του στη διάρκεια του χρόνου, προκύπτει η σημερινή εικόνα του ελληνικού Χρηματοπιστωτικού Συστήματος. Στη συνέχεια αναπτύσσονται τα επιμέρους είδη κινδύνων με τους οποίους έρχονται αντιμέτωπες οι τράπεζες και απειλούν τόσο τη φερεγγυότητα του Τραπεζικού Συστήματος όσο και εν γένει τη λειτουργία της οικονομίας. Στην προσπάθεια αντιμετώπισης των κινδύνων, έχει τεθεί σε εφαρμογή μία σειρά ρυθμιστικών πλαισίων και εποπτικών απαιτήσεων, οι οποίες προϊόντος του χρόνου περιλαμβάνουν συμπεράσματα από τις αδυναμίες που ανέδειξε η οικονομική κρίση του 2008. Συνοπτικά, από τις εποπτικές απαιτήσεις της Βασιλείας Ι στη Βασιλεία ΙΙΙ αποτυπώνεται η μετάβαση της τραπεζικής πολιτικής από τη μονομερή έμφαση στην κάλυψη του πιστωτικού κινδύνου στην κάλυψη και του κινδύνου ρευστότητας. Βάσει του προαναφερθέντος ρυθμιστικού πλαισίου, ακολουθεί μία μελέτη διαχείρισης κινδύνου κεφαλαιακής επάρκειας και ρευστότητας δύο εκ των μεγαλύτερων ελληνικών συστημικών Τραπεζικών Ιδρυμάτων, της Εθνικής Τράπεζας της Ελλάδος ΑΕ και της Πειραιώς Financial Holdings ΑΕ. Η μελέτη αυτή είναι εστιασμένη στα έτη 2018-2020, προκειμένου να αποτυπώσει την πορεία των δύο αυτών τραπεζών το χρονικό διάστημα εξόδου από τα μέτρα ελέγχου κεφαλαίων (capital controls) μέχρι και τα αποτελέσματα της πανδημίας covid-19. Τα αποτελέσματα αυτής της μελέτης είναι σε θέση να αποτυπώσουν εάν τα δύο αυτά Πιστωτικά Ιδρύματα συμμορφώνονται με τις εποπτικές απαιτήσεις και βαδίζουν σε ασφαλή κατεύθυνση έναντι των κινδύνων. Καταλήγοντας, η διαρκής συμμόρφωση στις εποπτικές απαιτήσεις και η αποφυγή απόκτησης επισφαλών στοιχείων ενεργητικού είναι ο μόνος τρόπος για να μπορέσουν οι ανωτέρω τράπεζες να επιτελέσουν τον σημαντικό ρόλο τους στην οικονομική ανάπτυξη και εν τέλει στην κοινωνική ευημερία.
Additional file 5 of Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
Creators: name: Andersson, Peder
name: Johnsson, Jesper
name: Björnsson, Ola
name: Cronberg, Tobias
name: Hassager, Christian
name: Zetterberg, Henrik
name: Stammet, Pascal
name: Undén, Johan
name: Kjaergaard, Jesper
name: Friberg, Hans
name: Blennow, Kaj
name: Lilja, Gisela
name: Wise, Matt P.
name: Dankiewicz, Josef
name: Nielsen, Niklas
name: Frigyesi, Attila
Publisher: name: figshare
Year: 2021
Subjects: Space Science
Cell Biology
Biotechnology
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Additional file 5: Table 1C. Day 2–48 hours of ICU treatment.