title: ÐÐ½Ð°Ð»Ð¸Ð· Ð±Ð¸Ð¾Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ Ð³ÐµÐ¼Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ ÐºÑÐ¾Ð²Ð¸ ÐºÑÑÑ Ð¿ÑÐ¸ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¼ÐµÑÑÐ½Ð¾Ð³Ð¾ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Analysis of biochemical and hematological parameters of rat blood during implantation of a local hemostatic agent
Creators: name: Ð¤ÐµÐ´Ð¾ÑÐ¾Ð², ÐÐ²Ð³ÐµÐ½Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¼ÐµÑÑÐ½Ð¾Ðµ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÑÐµÐ´ÑÑÐ²Ð¾
Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÑ
Ð´Ð¾ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ
Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ
local hemostatic agent
safety
preclinical studies
implantation

description: ÐÑÐ¿ÑÑÐºÐ½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÑÐµÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¾Ð±ÑÐµÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð² Ð¾ÑÐ²ÐµÑ Ð½Ð° Ð²Ð½ÑÑÑÐ¸Ð¿Ð¾Ð»Ð¾ÑÑÐ½ÑÑ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ Ð¼ÐµÑÑÐ½Ð¾Ð³Ð¾ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð° (ÐÐÐ¡) Ð´Ð»Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð½Ð° Ð¿Ð¾Ð»Ð¾Ð²Ð¾Ð·ÑÐµÐ»ÑÑ ÐºÑÑÑÐ°Ñ. Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¸ÑÐ¿ÑÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ Ð±ÐµÑÐ¿Ð¾ÑÐ¾Ð´Ð½ÑÐµ ÐºÑÑÑÑ, Ð²Ð¾Ð·ÑÐ°ÑÑÐ¾Ð¼ 3 Ð¼ÐµÑÑÑÐ°. ÐÐ¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ Ð¸ÑÐ¿ÑÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐµÐºÑÐ° Ð² Ð±ÑÑÑÐ½ÑÑ Ð¿Ð¾Ð»Ð¾ÑÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð°ÑÑ Ð¾Ð´Ð½Ð¾ÐºÑÐ°ÑÐ½Ð¾. ÐÑÐµÐ½Ð¸Ð²Ð°ÐµÐ¼ÑÐ¼Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ°Ð¼Ð¸ Ð² ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸: Ð²ÑÐ¶Ð¸Ð²Ð°ÐµÐ¼Ð¾ÑÑÑ, ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ°Ñ ÐºÐ°ÑÑÐ¸Ð½Ð° Ð¸Ð½ÑÐ¾ÐºÑÐ¸ÐºÐ°ÑÐ¸Ð¸, Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° Ð¼Ð°ÑÑÑ ÑÐµÐ»Ð°, Ð²Ð¾Ð´Ð¾- Ð¸ ÐºÐ¾ÑÐ¼Ð¾Ð¿Ð¾ÑÑÐµÐ±Ð»ÐµÐ½Ð¸Ðµ; Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾ÑÐµÐ½ÐºÐ° Ð³ÐµÐ¼Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ ÐºÑÐ¾Ð²Ð¸ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¾ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿Ð¾ÑÐ»Ðµ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ° Ð² Ð±ÑÑÑÐ½ÑÑ Ð¿Ð¾Ð»Ð¾ÑÑÑ Ð² Ð´Ð¾Ð·Ðµ 512 Ð¼Ð³/ÐºÐ³ Ð³Ð¸Ð±ÐµÐ»Ñ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð½Ðµ Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð°, Ð½Ðµ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¾Ð² Ð¾Ð±ÑÐµÐ¹ ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÐ¸, ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¾Ð² Ð¸Ð½ÑÐ¾ÐºÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¸Ð»Ð¸ Ð´ÑÑÐ³Ð¾Ð³Ð¾ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾Ð³Ð¾ Ð½ÐµÐ±Ð»Ð°Ð³Ð¾Ð¿ÑÐ¸ÑÑÐ½Ð¾Ð³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ°. ÐÐ¸Ð±ÐµÐ»Ñ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð° Ð½Ðµ Ð±ÑÐ»Ð°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¿ÐµÑÐµÐ½Ð¾ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÐ¼Ð¸ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ ÐÐÐ¡ Ð² Ð±ÑÑÑÐ½ÑÑ Ð¿Ð¾Ð»Ð¾ÑÑÑ Ð² Ð´Ð¾Ð·Ðµ 512 Ð¼Ð³/ÐºÐ³.
description: The graduate work presents the results of an experimental study to investigate the general toxic effect in response to intracavitary implantation of local hemostatic agent (LHA) for use in sexually mature rats. The study was conducted on the basis of the Federal State Budgetary Institution "Scientific-Clinical Center of Toxicology named after Academician S.N. Golikov of the Federal Medical and Biological Agency" in the period from 14.08.2023 to 30.11.2023. As a test specimen were used mongrel rats, 3 months old. Implantation of the test object into the abdominal cavity was performed once. The factors evaluated during the work were: survival rate, clinical picture of intoxication, effect on body weight, water and feed consumption; hematologic and biochemical indices of blood of animals were also evaluated. As a result of the study it was found that after implantation of the investigated sample in the abdominal cavity at a dose of 512 mg/kg the death of animals was not registered, no signs of general toxicity, specific signs of intoxication or other significant adverse effect of the investigated sample were revealed. No animal deaths were registered. The obtained data indicate normal tolerance of animals to implantation of LHA in the abdominal cavity at a dose of 512 mg/kg.