cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Determinin the CNS action of anorectic gut hormones in humans using functional MRI
Creators: name: De Silva, Akila
Publisher: name: Imperial College London
Year: 2012

description: Understanding how the brain controls appetite offers promising inroads towards developing new therapies for obesity. Peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) are anorectic hormones that are co-released post-prandially by the gut. Both have been shown to physiologically inhibit appetite and food intake when administered to humans. However, the mechanisms by which they regulate appetite through the central nervous system (CNS) remain poorly understood. Functional magnetic resonance imaging (fMRI) is a tool that has recently been used to determine the CNS pathways that mediate the action of appetite-modulating hormones. This dissertation investigates the action of the anorectic gut hormones PYY3-36 and GLP-17-36 amide, infused intravenously over 90 minutes in 15 lean, healthy human subjects following an overnight fast. Using blood oxygen level dependent (BOLD) fMRI, I have determined the effects of PYY3-36 and GLP-17-36 amide on CNS appetite centres and subsequent food intake, comparing the effects with those seen physiologically following a standard meal. The combined administration of PYY3-36 and GLP-17-36 amide to fasted human subjects led to similar reductions in BOLD fMRI brain activity in a priori regions of interest as observed physiologically following feeding, especially in the insular cortex. Additionally, compared with infusion of saline, co-administration of PYY3-36 at 0.3 pmol/kg/min with GLP-17-36 amide at 0.8 pmol/kg/min led to a 27.0% reduction in ad libitum energy intake at a buffet lunch served immediately after the infusion. The reduction in ad libitum energy intake following the combination infusion of PYY3-36 and GLP-17-36 amide was similar to that observed when saline was infused in subjects following consumption of a set breakfast (23.5% reduction in ad libitum energy intake at a buffet lunch served immediately after the infusion). My findings provide direct evidence that the combined action of PYY3-36 and GLP-17-36 amide in the brain could explain post-prandial satiety.
ULCPP URSP Ceramic and Lithic Tabulations
Creators: name: Oas, Sarah
Year: 1995
Subjects: Lyman Lake State Park
Upper Little Colorado River
Cibola
Archaic
Basketmaker III
Pueblo I
Pueblo II
Pueblo III
Pueblo IV
Ancestral Puebloan
AZ Q:11:74(ASM)
AZ Q:11:118(ASM)
Baca Pueblo
Rattlesnake Point Pueblo
Hamlet / Village
Domestic Structures
Resource Extraction / Production / Transportation Structure or Features
Quarry
Room Block / Compound / Pueblo
Rock Art
Domestic Structure or Architectural Complex
Settlements
Ceramic
Chipped Stone
Ground Stone
ULCPP
Systematic Survey

description: Upper Little Colorado Prehistory Project Udall Ranch Survey ceramic and lithic tabulation forms
Stable (Cu, Zn) and radiogenic (Pb) isotope geochemistry of airborne particulate matter
Creators: name: Dong, Shuofei
Publisher: name: Imperial College London
Year: 2012

description: The aim of the thesis was to test the isotope systematics of Cu, Zn and Pb in atmospheric particulate matter and potential source material in order to critically discuss its implications and applications to studies of global biogeochemical cycles and anthropogenic impact. Four specific objectives were addressed: First, we tailored existing analytical methods to enable for the first time accurate and precise Cu and Zn isotope ratio measurements in dust and aerosol samples with low element content. Second, we studied the Pb, Cu and Zn isotope composition in aerosols collected in London to test their potential to trace anthropogenic sources in the urban atmosphere. Third, we characterized the Cu and Zn isotope systematics of major Asian and African dust sources and constrained possible controls and implications on the marine isotope signature. Finally, we investigated the isotope fractionation of Zn during dissolution experiments with acidic solution of natural dust to test the possible effect of atmospheric processing on the isotope signature of deposited Zn. The conclusions from this work are: First, stable isotopes confirm that brake and tyre emissions are the likely dominant sources of Zn and Cu in urban aerosols and that recycled Pb deposited originally from leaded gasoline still contributes significantly to the burden of atmospheric Pb in London. Second, we show that the Cu and Zn isotope signatures vary significantly between the major Asian and African dust sources and we find a significant correlation between Cu isotope ratio and illite content. Mass balance calculation suggest that bulk samples record faithfully the isotope signature of the <4 μm fraction. Third, significant isotope fractionation of Zn is observed during dust dissolution suggesting that the isotope signature of Zn deposited in the surface ocean is not only controlled by source mixing but also by atmospheric processing during long range transportation. The work clearly supports the initial hypothesis that metal isotopes are powerful sources to study global and regional biogeochemical cycles.
Reinforcement Learning for Resource Provisioning in Vehicular Cloud
Creators: name: Salahuddin, Mohammad A.
name: Al-Fuqaha, Ala
name: Guizani, Mohsen
Publisher: name: arXiv
Year: 2018
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This article presents a concise view of vehicular clouds that incorporates various vehicular cloud models, which have been proposed, to date. Essentially, they all extend the traditional cloud and its utility computing functionalities across the entities in the vehicular ad hoc network (VANET). These entities include fixed road-side units (RSUs), on-board units (OBUs) embedded in the vehicle and personal smart devices of the driver and passengers. Cumulatively, these entities yield abundant processing, storage, sensing and communication resources. However, vehicular clouds require novel resource provisioning techniques, which can address the intrinsic challenges of (i) dynamic demands for the resources and (ii) stringent QoS requirements. In this article, we show the benefits of reinforcement learning based techniques for resource provisioning in the vehicular cloud. The learning techniques can perceive long term benefits and are ideal for minimizing the overhead of resource provisioning for vehicular clouds.
description: 8 pages, 6 figures
MACROFLORAL, PHYTOLITH, STARCH, AND ORGANIC RESIDUE (FTIR) ANALYSIS OF SAMPLES FROM HERKIMER HOUSING AUTHORITY, SITE HHA-1 PRECONTACT, HERKIMER COUNTY, NEW YORK
Creators: name: Cummings, Linda Scott
Year: 2020
Subjects: New York (State / Territory)
Herkimer (County)
HHA-1 PreContact
HERKIMER HOUSING AUTHORITY
Domestic Structure or Architectural Complex
Fire Cracked Rock
Starch Analysis
Macrofloral Analysis
Phytolith Analysis
FTIR
organic residue analysis
Data Recovery / Excavation

description: Site HHA-1 represents precontact use of a level floodplain at the confluence of two major waterways, the Mohawk River and West Canada Creek. Three samples were collected from Feature 1, a circular fire-cracked rock (FCR) deposit, for macrofloral, phytolith, starch, and organic residue analysis, the latter using Fourier Transform Infrared Spectroscopy. These analyses examined sediments and FCR from the feature in search of evidence of economic activity.
Additional file 5 of TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum
Creators: name: Duan, Yang
name: Li, Jianjun
name: Qiu, Sujun
name: Ni, Songjia
name: Cao, Yanlin
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5: Table S1. Patients information in this study.
Protolichus sigillator Mironov & Dabert 2010
Creators: name: LIU, DONG
name: YI, TIAN-CI
name: XU, YUN
name: ZHANG, ZHI-QIANG
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Acari
Pterolichidae
Protolichus
Protolichus sigillator

description: Protolichus sigillator Mironov & Dabert, 2010: 19
— Holotype heteromorph male (MNHN, 34A9), ex Chalcopsitta scintillata chloroptera (Salvadori, 1876), New Guinea, Indonesia.
description: Published as part of LIU, DONG, YI, TIAN-CI, XU, YUN & ZHANG, ZHI-QIANG, 2013, Hotspots of new species discovery: new mite species described during 2007 to 2012, pp. 1-102 in Zootaxa 3663 (1) on page 80, DOI: 10.11646/zootaxa.3663.1.1, http://zenodo.org/record/5630595
POLLEN ANALYSIS OF SAMPLES FROM SITE 48SW3006 SWEETWATER COUNTY, WYOMING
Creators: name: Cummings, Linda Scott
Year: 2020
Subjects: Wyoming (State / Territory)
Sweetwater (County)
48SW3006
19-WAS-008
Macrobotanical
Pollen Analysis
Data Recovery / Excavation

description: Site 48SW3006, located in southwestern Wyoming south of the Chain Lakes Rim and north of Wamsutter, represents multiple hunter-gatherer open camp fire pits. Ten thermal basins were selected for pollen analysis. Radiocarbon dates for these features range from 5430 ± 30 BP to 1090 ± 30 BP. Two stratigraphic samples and a modern surface sample complete the pollen record for this site.
Mathematical Modelling of Tuberculosis Infection
Creators: name: El-Khairi, Muna
Publisher: name: Imperial College London
Year: 2012

description: Tuberculosis is one of the leading causes of death by infectious disease in the world today. However, the majority of individuals infected with Mycobacterium tuberculosis are able to contain bacterial growth and establish a latent infection. The aim of this thesis is to develop mathematical models to study the progression of disease in individuals infected with Mycobacterium tuberculosis. This work focuses on understanding bacterial and host defence mechanisms that govern the outcome of infection, and on identifying factors that affect the outcome of anti-tuberculosis chemotherapy. A detailed model of human tuberculosis infection in the lung and peripheral draining lymph node is developed that builds on models published in the literature. Analysis of this model suggests a differential role for innate and adaptive immune responses in determining the outcome of infection, and a possible role for an intracellular bacterial population in establishing a persistent infection. For certain parameter values this system has multiple steady states so the outcome of infection may also depend on initial conditions. This model is then modified to incorporate the effect of treatment with the antimycobacterial agent rifampicin. The model is used to investigate different treatment regimens and simulation results suggest that the length of tuberculosis therapy can be reduced by further optimizing the standard rifampicin dosing regimen. Simple predator-prey type models of infection are constructed to gain further insight into the mechanisms that control the establishment and maintenance of latency. These models support observations made from the full disease model regarding the roles of innate and adaptive immunity in fighting infection and the influence of an intracellular bacterial population that is protected from the innate immune system. The addition of a population of non-replicating or slow growing bacteria contributes to the establishment of latent infection and generally makes latency a more robust and stable state.
Muon Tracing and Image Reconstruction Algorithms for Cosmic Ray Muon Computed Tomography
Creators: name: Liu, Zhengzhi
name: Chatzidakis, Stylianos
name: Scaglione, John M.
name: Liao, Can
name: Yang, Haori
name: Hayward, Jason P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Cosmic ray muon computed tomography (μCT) is a new imaging modality with unique characteristics that could be particularly important for diverse applications including nuclear nonproliferation, spent nuclear fuel monitoring, cargo scanning, and volcano imaging. The strong scattering dependence of muons on atomic number Z in combination with high penetration range could offer a significant advantage over existing techniques when dense, shielded containers must be imaged. However, μCT reconstruction using conventional filtered back-projection is limited due to the overly simple assumptions that do not take into account the effects of multiple Coulomb scattering prompting the need for more sophisticated approaches to be developed. In this paper, we argue that the use of improved muon tracing and scattering angle projection algorithms as well as use of an algebraic reconstruction technique should produce muon tomographic images with improved quality or require fewer muons to produce the same image quality compared to the case where conventional methods are used. We report on the development and assessment of three novel muon tracing methods and two new scattering angle projection methods for μCT. Simulated dry storage casks with single and partial missing fuel assemblies were used as numerical examples to assess and compare the proposed methods. The simulated images showed an expected improvement in image quality when compared with more conventional techniques, even without muon momentum information, which should lead to improved detection capability, even for partial defects.
description: 11 pages
title: 02_1630
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
THE FORMED PERCEPTIVE ABILITY OF THE TUTOR AND ITS PSYCHOLOGICAL CHARACTERISTICS.
Creators: name: Nurmatova, Madina
Publisher: name: Zenodo
Year: 2024

description: In this article about the perceptive ability of the tutor's personality and its significance in the process of students' perception and psychological characteristics are described. The article contains information about the perceptive mechanisms of the tutor's communication, which is shown in the example of the tutor's interaction with the student..
New vortex solution in SU(3) gauge-Higgs theory
Creators: name: Schaposnik, F. A.
name: Suranyi, P.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Following a brief review of known vortex solutions in SU(N) gauge-adjoint Higgs theories we show the existence of a new ``minimal'' vortex solution in SU(3) gauge theory with two adjoint Higgs bosons. At a critical coupling the vortex decouples into two abelian vortices, satisfying Bogomol'nyi type, first order, field equations. The exact value of the vortex energy (per unit length) is found in terms of the topological charge that equals to the N=2 supersymmetric charge, at the critical coupling. The critical coupling signals the increase of the underlying supersymmetry.
description: 15 pages
NP: The TP IPR Dataset for RECALL Purposes
Creators: name: Naipthan Phillips
Publisher: name: figshare
Year: 2018
Subjects: subject: 190202 Computer Gaming and Animation
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Recall the Metadata for Games development, design, Fighting, Martial Arts, to support product design for copyright and IPR purposes. This registration marks the recording of the concept as the licensing options only support this publicly available statement via metadata required for discovery purposes. The aim is to ensure any Recall type developments in the given discipline or any specific details from which an association could be made is progressed only through permissions of the author/designer contact.
Oral history interview with Justin G. Turner, 1973
Publisher: name: Columbia University
Year: 2020
Subjects: Manuscripts--Collectors and collecting
Oral history--Israel
History--Jews

description: First meeting with Allan Nevins through the Tercentennial, the 300th anniversary of the first Jews arriving in New Amsterdam; later associations with Nevins: Pen and Quill Club, Huntington Library, Oral History Project, University of Judaism; use of oral history methods in Israel concerning the Declaration of Independence of Israel.
Generalised particle filters
Creators: name: Li, Kai
Publisher: name: Imperial College London
Year: 2012

description: The ability to analyse, interpret and make inferences about evolving dynamical systems is of great importance in different areas of the world we live in today. Various examples include the control of engineering systems, data assimilation in meteorology, volatility estimation in financial markets, computer vision and vehicle tracking. In general, the dynamical systems are not directly observable, quite often only partial information, which is deteriorated by the presence noise, is available. This naturally leads us to the area of stochastic filtering, which is defined as the estimation of dynamical systems whose trajectory is modelled by a stochastic process called the signal, given the information accumulated from its partial observation. A massive scientific and computational effort is dedicated to the development of various tools for approximating the solution of the filtering problem. Classical PDE methods can be successful, particularly if the state space has low dimensions (one to three). In higher dimensions (up to ten), a class of numerical methods called particle filters have proved the most successful methods to-date. These methods produce approximations of the posterior distribution of the current state of the signal by using the empirical distribution of a cloud of particles that explore the signal’s state space. In this thesis, we discuss a more general class of numerical methods which involve generalised particles, that is, particles that evolve through spaces larger than the signal’s state space. Such generalised particles include Gaussian mixtures, wavelets, orthonormal polynomials, and finite elements in addition to the classical particle methods. This thesis contains a rigorous analysis of the approximation of the solution of the filtering problem using Gaussian mixtures. In particular we deduce the L2-convergence rate and obtain the central limit theorem for the approximating system. Finally, the filtering model associated to the Navier-Stokes equation will be discussed as an example.
The molecular basis of host range restriction of avian influenza virus polymerases in mammalian hosts
Creators: name: Moncorgé, Olivier
Publisher: name: Imperial College London
Year: 2012

description: Influenza A virus adaptation to humans is a rare but recurrent event that can result in a pandemic. The influenza polymerase, composed of the viral proteins PB1, PB2 and PA, is responsible for transcription and replication of the viral genome. Typical avian-origin influenza polymerases are restricted in human cells and polymerase subunit PB2 is particularly involved in this restriction. Residue 627 of PB2 is a glutamic acid in almost all avian influenza viruses, and mutation to a lysine is a potent enhancer of avian polymerase function in human cells. However, the underlying molecular mechanism and the cellular factors modulating avian-origin influenza replication in mammals are not known. Using a cell based replication assay in heterokaryons formed between avian and human cells, we concluded that the restriction is not due to a dominant human inhibitory factor. We also showed that supply of avian factors to human cells stimulated the activity of an avian-origin influenza polymerase and a functional screen was set up to attempt to isolate such chicken co-factor(s). We hypothesised that PB2 E627K mutation enhances the viral polymerase activity by optimizing an interaction with a human co-factor. A biochemical approach was used to try to identify this factor. Pigs are thought to be more susceptible to avian influenza than other mammalian species and are a supposed “mixing vessel” for influenza A viruses. To compare the replicative capacity of different influenza polymerases in pig, human and avian cells, an influenza polymerase assay in pig cells was set up. This assay was also used to study the impact in pig cells of known PB2 mammalian adaptive mutations. No obvious difference in the capacity of pig and human cells to support influenza polymerase activity was found, questioning the suggested susceptibility of pigs to influenza. Viruses from the avian H9N2 G1 lineage have been responsible for some human infections. Despite having none of the known mammalian signatures, we found the H9N2 G1 polymerase was active in human and pig cells. This study identified H9N2 G1 PA protein as being particularly mammalian adapted, highlighting the role of PA in influenza mammalian adaptation.
Stochastic sampling of the isothermal-isobaric ensemble: phase diagram of crystalline solids from molecular dynamics simulation
Creators: name: Cajahuaringa, Samuel
name: Antonelli, Alex
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A methodology to sample the isothermal-isobaric ensemble using Langevin dynamics is proposed, which combines novel features of geometric integrators for the equations of motion. By employing the Trotter expansion, the methodology generates a robust, symmetric and accurate numerical algorithm. In order to show that the proposed method correctly samples the phase-space, simulations in the isotropic NPT ensemble were carried out for two analytical examples. Also this method permits to study a solid-solid phase transition, by conducting a fully flexible-cell molecular dynamics simulation. Additionally, we present an efficient method to determine the Gibbs free energy in a wide interval of pressure along an isothermal path, which allows us to determine the transition pressure in a driven by pressure solid-solid phase transition. Our calculations show that the methodology is highly suitable for the study of phase diagram of crystalline solids.
POLLEN ANALYSES OF SAMPLES FROM SITE 48CR11230, CARBON COUNTY, WYOMING
Creators: name: Cummings, Linda Scott
Year: 2020
Subjects: Wyoming (State / Territory)
Carbon (County)
48CR11230
20-WAS-008
Pollen
Pollen Analysis
Data Recovery / Excavation

description: Site 48CR11230 is situated in the southeastern portion of the Great Divide Basin, approximately five miles north of the Continental divide. Hansen Eraw and an ephemeral drainage are located approximately three quarters of a mile to the west-northwest and 430 m to the south, respectively. Sited along the northwest slope of a north-south trending ridge approximately 7066 feet above mean sea level, this site is covered by an aeolian sand sheet. Multiple hunter-gatherer open camp fire pits were identified, and four were sampled, along with two archaeological strata and the modern surface, creating a pollen record of past and present vegetation.
MPEC 2024-E117 : 2024 EN2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 EN2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
The Zollverein and the Formation of a Customs Union
Creators: name: Ploeckl, Florian
Publisher: name: The University of Adelaide
Year: 2018
Subjects: subject: 140203 Economic History
subject: FOS: Economics and business

description: The Zollverein, the German customs union of 1834, was the institutional centrepiece of Germany’s economic unification. A bargaining model is applied to analyze the structure of its negotiation process and accession sequence. The existence of negative coalition externalities, the effect of a coalition on non-participants, led Prussia to choose sequential over multilateral negotiations. The nature of these externalities within the areas of financial revenues, trade policy and domestic political economy also explains the observed accession sequence. The choice of a customs union as institutional structure allowed Prussia to extract higher concessions from other states due to stronger coalition externalities.
Fabrication of Poly(Vinylidene Fluoride) (PVDF) Membranes
Creators: name: Hashim, Nur Awanis Binti
Publisher: name: Imperial College London
Year: 2011

description: In water filtration processes, the employment of polymeric membranes has become increasingly popular over the past few decades. However, the application of membrane processes is often limited due to the low fluxes and membrane failures caused by fouling and low membrane durability, which eventually leads to high operating costs in comparison with conventional processes. These limitations could be overcome by the development of high performance membranes with enhanced properties through a cost effective method. This thesis explores the preparation of high performance poly(vinylidene fluoride) (PVDF) membranes with the use of inorganic silica particles via a conventional immersion precipitation method and from an amphiphilic graft copolymer. A technique to improve the performance of PVDF membranes fabricated via immersion precipitation has been developed, which involves using inorganic silica (SiO2) particles during the preparation of the dope solution, followed by subsequent acid or alkaline treatments of the resultant membranes. By removing the SiO2 particles from the membrane substrates using either an acid or alkaline treatment, the resultant membranes exhibit an interconnected porous structure accompanied by a significant improvement in the water permeability. Due to the poor mechanical strength demonstrated by the NaOH treated membranes, detailed investigations of the stability of PVDF membranes in NaOH solutions are carried out on hollow fibre membranes prepared from different raw materials. Hollow fibre membranes exhibit different degrees of chemical degradation upon exposure to a sodium hydroxide solution under various conditions. Also, a simplified method has been developed as a cost effective way for the preparation of PVDF membranes with improved hydrophilicity, fouling resistance and water permeability from the amphiphilic graft copolymer, PVDF-g-PEGMA, which has a PVDF backbone and poly(ethylene glycol) methyl ether methacrylate (PEGMA) side chains. By eliminating three common steps involved during the conventional preparation method, the use of chemicals and energy can be substantially reduced.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0497
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0497, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0497, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Induction of gut homing T cells by systemic dendritic cells
Creators: name: Hornig, Julia
Publisher: name: Imperial College London
Year: 2011

description: An effective vaccine against mucosal pathogens such as the Human Immunodeficiency Virus 1 (HIV-1) must provide immunity at the mucosal level. Understanding the ability of mucosal dendritic cells (DCs) to induce gut homing lymphocytes plays a crucial parameter in the development of vaccines that mount a specific immune response in the intestine. Gut-tropic T cells are characterised by the expression of the integrin heterodimer α4β7 and the chemokine receptors CCR9 and CCR10, with CCR9 being specific for the small intestine. While CCR10 has been suggested to play a role in lymphocyte homing to the large intestine, together with CCR4, it has been implicated in lymphocyte trafficking to the skin. In addition, it is thought that induction of gut homing T cells is associated with the ability of intestinal DCs to metabolise vitamin A to retinoic acid (RA). Mucosal vaccination is known to induce mucosal and systemic immune responses, while systemic vaccination has been thought to only induce systemic immune responses. However, recent publications have shown systemic vaccination to induce mucosal immune responses. This project investigates the ability of different types of human systemic DCs to modulate expression of receptors specific to mucosal and skin homing T cells in the presence of retinoids and vitamin D. Co-culture of DCs with various T cell populations in the presence of RA revealed the ability of systemic DCs to increase α4β7 expression and decrease surface expression of cutaneous lymphocyte-associated antigen (CLA), a marker for skin homing T cells. We also showed that vitamin D plays a role in modulating CCR4 and CCR10 expression. Having investigated the ability of RA to modulate homing receptor expression on T cells, we confirmed the potential of systemic DCs to metabolize retinol and retinal in vitro by molecular means and flow cytometric analysis. Finally, we examined the role of retinoic acid receptors (RARs) in regulating α4β7 and CLA expressing T cells. This is the first study that investigates the potential of different subsets of human systemic DCs to differentially induce and modulate homing properties of T cells in vitro. The findings presented in this thesis could have major implications in the development of systemic vaccines aimed at inducing mucosal immune responses.
Identification and functional analysis of novel components of the TRAIL apoptosis signalling pathway
Creators: name: Falschlehner, Christina
Publisher: name: Imperial College London
Year: 2009

description: Apoptosis, a controlled form of cell death, plays a central role in the development and homeostasis of multicellular organisms. Apoptosis induction can occur via intracellular mechanisms, for example after intensive DNA damage, or via triggering of death receptors. Death receptors belong to the tumour necrosis factor (TNF) receptor superfamily. Amongst the death receptors, the TNF-related apoptosisinducing ligand (TRAIL) and its five receptors stand out due to its complexity and tumour-specific killing activity. TRAIL can bind two apoptosis-inducing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5), two additional cell-bound receptors incapable of transmitting an apoptotic signal, TRAIL-R3 (LIT, DcR1) and TRAIL-R4 (TRUNDD, DcR2), sometimes also called decoy receptors, and lastly, a soluble receptor called osteoprotegerin (OPG). TRAIL has been shown to induce apoptosis in cancer cells in vivo without causing toxicity. On the basis of these findings, specific activation of TRAIL-R1 and TRAILR2 is currently evaluated for tumour therapy in early clinical trials. Yet, primary tumours are mostly resistant to TRAIL-induced apoptosis. Interestingly however, chemo- and radiotherapy can sensitise primary tumour cells to TRAIL-induced apoptosis whereas normal cells remain resistant also to such combinations. To understand the molecular mechanisms of tumour-cell-specific sensitisation to TRAIL, genome-wide RNA interference (RNAi) was used in an unbiased approach with the aim to identify novel factors involved in TRAIL-induced apoptosis and its inhibition. By screening the TRAIL-sensitive human cervix carcinoma cell line HeLa novel modulators of TRAIL signalling were identified. The studies presented in this thesis focus on the identification and validation of factors that are required for TRAIL apoptosis signalling, the molecular characterisation and the determination of their biochemical mechanism of action.
Borchers' Commutation Relations and Modular Symmetries
Creators: name: Kuckert, Bernd
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently Borchers has shown that in a theory of local observables, certain unitary and antiunitary operators, which are obtained from an elementary construction suggested by Bisognano and Wichmann, commute with the translation operators like Lorentz boosts and \pct-operators, respectively. We conclude from this that as soon as the operators considered implement {\em any} symmetry, this symmetry can be fixed up to at most some translation. As a symmetry, we admit any unitary or antiunitary operator under whose adjoint action any algebra of local observables is mapped onto an algebra which can be localized somewhere in Minkowski space.
description: LaTeX file
Passeroptes hippolais Bochkov & Mironov 2012
Creators: name: LIU, DONG
name: YI, TIAN-CI
name: XU, YUN
name: ZHANG, ZHI-QIANG
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Acari
Dermationidae
Passeroptes
Passeroptes hippolais

description: Passeroptes hippolais Bochkov & Mironov, 2012: 44
— Holotype male (ZISP 4843), ex Hippolais icterina (Vieillot) (Passeriformes: Acrocephalidae) [body skin], Kaliningrad Province, Curonian spit, Rybachy village, Russia (55°09'15"N, 20°51'14"E).
description: Published as part of LIU, DONG, YI, TIAN-CI, XU, YUN & ZHANG, ZHI-QIANG, 2013, Hotspots of new species discovery: new mite species described during 2007 to 2012, pp. 1-102 in Zootaxa 3663 (1) on page 80, DOI: 10.11646/zootaxa.3663.1.1, http://zenodo.org/record/5630595
Borders, Market Access and Urban Growth; The Case of Saxon Towns and the Zollverein
Creators: name: Ploeckl, Florian
Publisher: name: The University of Adelaide
Year: 2018
Subjects: subject: 140203 Economic History
subject: FOS: Economics and business
subject: 140218 Urban and Regional Economics

description: The Zollverein, the 1834 customs union between independent German states, removed all internal borders. This paper investigates its economic impact focussing
on urban population growth in the state of Saxony. Implications from an economic geography model are tested with a data set on town populations and location characteristics as well as an improved distance measure created with GIS techniques to include geography and infrastructure. Saxony's Zollverein membership led to significantly higher growth for towns close to the liberalized border. The effect depended on a town's size, was reinforced through neighboring markets and worked through influencing migration and natural increase.
PROTEIN RESIDUE (CIEP) ANALYSES OF SAMPLES FROM SITES HbRi-33, HaRk-8, HaRl-53, BRITISH COLUMBIA, CANADA
Creators: name: Cummings, Linda Scott
Year: 2020
Subjects: British Columbia (State / Territory)
Canada
HaRk-8
HbRi-33
HaRl-53
Chipped Stone
Protein Residue Analysis
CIEP Analysis
Data Recovery / Excavation

description: Site HbRi-33 overlooks Peace River and Halfway River to the west, lying approximately 1 km northwest of the confluence of these two rivers. A projectile point recovered from Level 2 was submitted for protein residue analysis. Site HaRk-8 is located approximately 60 km westsouthwest of Fort St. John in northeast British Columbia near the confluence of the peace River and Right Creek. A single scraper recovered from Level 2 was submitted for protein residue analysis. Site HaRl-53 overlooks the Peace River to the southwest and lies approximately 513 m north of the confluence of the Peace River the Maurice Creek. Two scrapers were submitted for protein residue analysis.
Stem cell bioprocessing: The bioengineering of lung epithelium in 3D from embryonic stem cells
Creators: name: Ismail, Siti N.
Publisher: name: Imperial College London
Year: 2009

description: Stem cell therapies and tissue engineering strategies are required for the clinical treatment of respiratory diseases. Previous studies have established protocols for the differentiation of airway epithelium from stem cells but have involved costly and laborious culture methods. The aim of this thesis was to achieve efficient and reproducible maintenance and differentiation of embryonic stem cells to airway epithelium, in 2D and 3D culture, by developing appropriate bioprocessing technology. Firstly, the 2D differentiation process of human and murine ES cells into pulmonary epithelial cells was addressed. The main finding in was that the proportion of type II pneumocytes, the major epithelial component of the gas-exchange area of lung, differentiated with this method was higher than that obtained in previous sudies, 33% of resultant cell expressed the specific marker surfactant protein C (SPC) compared with up to 10%. Secondly, the maintenance and differentiation was carried out in 3D. A protocol was devised that maintained undifferentiated human ES cells in culture for more than 200 days encapsulated in alginate without any feeder layer or growth factors. For ES cell differentiation in 3D, a method was devised to provide a relatively cheap and simple means of culture and use medium conditioned by a human pneumocyte tumour cell line (A549). The differentiation of human and murine ES cells into pulmonary epithelial cells, particularly type II pneumocytes, was found to be upregulated by culture in this conditioned medium, with or without embryoid body formation. The third step was to test whether this differentiation protocol was amenable to scale-up and automation in a bioreactor using cell encapsulation. It was possible to show that encapsulated murine ES cells cultured in static, co-culture or rotating wall bioreactor (HARV) systems, differentiate into endoderm and, predominantly, type I and II pneumocytes. Flow cytometry revealed that the mean yield of differentiated type II pneumocytes was around 50% at day 10 of cultivation. The final stage of the work was to design and produce a perfusion system airlift bioreactor to mimic the pulmonary microenvironment in order to achieve large scale production of biologically functional tissue. The results of these studies thus provide new protocols for the maintenance of ES cells and their differentiation towards pulmonary phenotypes that are relatively simple and cheap and can be applied in bioreactor systems that provide for the kind of scale up of differentiated cell production needed for future clinical applications.
Open String on Symmetric Product
Creators: name: Fuji, Hiroyuki
name: Matsuo, Yutaka
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We develop some basic properties of the open string on the symmetric product which is supposed to describe the open string field theory in discrete lightcone quantization (DLCQ). After preparing the consistency conditions of the twisted boundary conditions for Annulus/Möbius/Klein Bottle amplitudes in generic non-abelian orbifold, we classify the most general solutions of the constraints when the discrete group is $S_N$. We calculate the corresponding orbifold amplitudes from two viewpoints -- from the boundary state formalism and from the trace over the open string Hilbert space. It is shown that the topology of the world sheet for the short string and that of the long string in general do not coincide. For example the annulus sector for the short string contains all the sectors (torus, annulus, Klein bottle, Möbius strip) of the long strings. The boundary/cross-cap states of the short strings are classified into three categories in terms of the long string, the ordinary boundary and the cross-cap states, and the ``joint'' state which describes the connection of two short strings. We show that the sum of the all possible boundary conditions is equal to the exponential of the sum of the irreducible amplitude -- one body amplitude of long open (closed) strings. This is typical structure of DLCQ partition function. We examined that the tadpole cancellation condition in our language and derived the well-known gauge group $SO(2^{13})$.
description: 56 pages, 11 figures, Latex
Sensitisation to TRAIL-induced apoptosis by targeted inhibition of kinases
Creators: name: Papenfuss, Kerstin
Publisher: name: Imperial College London
Year: 2010

description: The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cell lines but not in normal cells. This property of TRAIL led to its development as a novel cancer drug. However, most primary tumour cells are TRAIL-resistant, yet, they can be sensitised by combining TRAIL with other cancer drugs. Kinase inhibitors have emerged as a new class of cancer drugs with high therapeutic potential and cancer cell specificity. The aim of this thesis was to determine the mechanism of TRAIL apoptosis sensitisation by inhibition of certain kinases that are specifically and aberrantly activated in cancer cells. When studying the TRAIL-induced phosphorylation of Bid it was discovered in this thesis that this phosphorylation was independent of ATM which has previously been described to phosphorylate Bid at this specific site. Remarkably, the ATM inhibitor KU-55933 used in this context was able to further sensitise HeLa cells to TRAIL-induced apoptosis and could break TRAIL resistance of the colon carcinoma cell line DLD1. As the combination of TRAIL and KU-55933 might represent a promising treatment option for cancer therapy this study focused on investigating the molecular mechanism that leads to TRAIL sensitisation by KU-55933. Surprisingly, TRAIL sensitisation by KU-55933 was independent of specific inhibition of ATM and, instead, achieved by inhibition of the phosphoinositide 3-kinase (PI3K) p110α isoform. Aberrant activation of PI3K α is a frequent tumour-specific alteration in various types of cancer including breast and colon carcinoma. It could be demonstrated that TRAIL apoptosis sensitisation of TRAIL-resistant DLD1 colon carcinoma cells by KU-55933 or PIK75, a specific inhibitor for p110α, required concomitant down-regulation of the cellular FLICE-inhibitory protein (cFLIP) and the X-linked Inhibitor of Apoptosis Protein (XIAP). Whilst suppression of cFLIP enhanced caspase-8 activation at the TRAIL death-inducing signalling complex (DISC), resulting in first cleavage of caspase-3, loss of XIAP enabled further cleavage and full activation of caspase-3. These results suggest that the combination of TRAIL or other TRAIL receptor agonists with inhibitors of PI3Kα may be an effective new strategy in cancer treatment capable of overcoming therapy resistance.
Skyrmions scattering in (2+1)-dimensions
Creators: name: Cova, R. J.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The scattering properties of the non-linear $O(3)$ model in (2+1)-D, modified by the addition of both a potential-like term and a Skyrme-like term, are considered. Most of the work is numerical. The skyrmion-scattering is found to be quasi-elastic, the skyrmions' energy density profiles remaining unscathed after collisions. In low-energy processes the skyrmions exhibit back-scattering, while at larger energies they scatter at right angles. These results confirm those obtained in previous investigations, in which a similar problem was studied for a different choice of the potential-like term.
description: 18 pages, latex, including 9 uufiled figures mailed separately via the 'figures' command; published by Helv Phys Acta Vol 68 (1995)
Noncommutative Open strings, D-brane and Duality
Creators: name: Maharana, J.
name: Pal, S. S.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider open strings ending on D-branes in the presence of constant metric, G, antisymmetric tensor, B and gauge field, A. The Hamiltonian is manifestly invariant under a global noncompact group; strikingly similar to toroidally compactified closed string Hamiltonian. The evolution equations for the string coordinates, $\{X^i \}$ and their dual partners, $\{Y_i \}$, are combined to obtain equations of motion invariant under the noncompact symmetry transformations. We show that one can start from a noncommutative theory, with nonvanishing G and B and mixed boundary conditions and then go over to a dual theory whose coordinates obey Dirichlet boundary conditions. It is possible to generate B-field by implementing the noncompact symmetry transformation. The connection between this duality transformation and Seiberg-Witten map is discussed.
description: Latex and 8pages,The discussion section is expanded, relation with Seiberg-Witten map is included. New references added