cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Opioid tolerance in methadone maintenance treatment
title: comparison of methadone and levomethadone in long-term treatment
titleType: Subtitle
Creators: name: Gutwinski, Stefan
name: Schoofs, Nikola
name: Stuke, Heiner
name: Riemer, Thomas G.
name: Wiers, Corinde E.
name: Bermpohl, Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Opioid
subject: Tolerance
subject: Long-term
subject: Maintenance treatment
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background This study aimed to investigate the development of opioid tolerance in patients receiving long-term methadone maintenance treatment (MMT). Methods A region-wide cross-sectional study was performed focusing on dosage and duration of treatment. Differences between racemic methadone and levomethadone were examined. All 20 psychiatric hospitals and all 110 outpatient clinics in Berlin licensed to offer MMT were approached in order to reach patients under MMT fulfilling the DSM IV criteria of opiate dependence. In the study, 720 patients treated with racemic methadone or levomethadone gave information on the dosage of treatment. Out of these, 679 patients indicated the duration of MMT. Results Treatment with racemic methadone was reported for 370 patients (54.5 %), with levomethadone for 309 patients (45.5 %). Mean duration of MMT was 7.5 years. We found a significant correlation between dosage and duration of treatment, both in a conjoint analysis for the two substances racemic methadone and levomethadone and for each substance separately. These effects remained significant when only patients receiving MMT for 1 year or longer were considered, indicating proceeding tolerance development in long-term treatment. When correlations were compared between racemic methadone and levomethadone, no significant difference was found. Conclusions Our data show a tolerance development under long-term treatment with both racemic methadone and levomethadone. Tolerance development did not differ significantly between the two substances.
Option pricing from a Bayesian perspective using the Dirichlet process.
Creators: name: Bédard, Tierry.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Mathematics.

description: There exist a wide variety of models for the pricing of derivative securities such as call and put options. This thesis introduces an alternative option pricing methodology based on a Monte Carlo simulation of the Dirichlet process. The model is constructed in a Bayesian framework, using the properties initially described by Ferguson [10, 11]. Given historical stock prices up to the present, we simulate various sample paths for future stock prices. This procedure is conducted under the hypothesis that the prior distribution of the stock returns has a Dirichlet process structure. The predicted option prices are then computed by averaging the option prices obtained for each simulated sample path. A considerable advantage of this model is that random draws are sampled from a mixed distribution which consists of a prior guess and the empirical process based on the initial random sample of stock returns. The methodology is applied to various examples throughout this thesis. The results are compared with some existing models, including exponential Brownian motion and the Black-Scholes option pricing formula.
Regional deposition and diagenesis of Lower Ordovician epeiric, platform carbonates: The Romaine Formation, Mingan Archipelago and Subsurface Anticosti Island, eastern Quebec.
Creators: name: Brennan-Alpert, Patricia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Geology.

description: This study integrates Mingan Islands outcrop and Anticosti subcrop facies analysis with petrography and stable isotope geochemistry to establish a current framework for the Lower Ordovician Romaine Formation in the western Anticosti Basin. Inner to midshelf strata form a wedge, thinning from midshelf to inner shelf and from west to east. A basal transgressive unit onlaps Precambrian basement; it is overlain by muddy, bioclastic limestones and dolostones arranged in two depositional sequences. In the lower sequence the transgressive lag is overlain by a peritidal unit (not developed in the inner shelf), followed by a subtidal unit and a second peritidal unit; the sequence boundary is nonerosive. In the upper sequence, peritidai facies are overlain in the west by a second subtidal unit, which is truncated from west to east by the regional unconformity. In the inner shelf, carbonates are pervasively dolomitized; in the midshelf, peritidal units are pervasively dolomitized but subtidal units are partially dolomitized. Petrography shows two stages of dolomitization, an early, synsedimentary to shallow burial stage characterized by planar replacement dolomites and a late stage characterized by nonplanar replacement dolomite, and pore and fracture filling dolomite cements. Stable Isotope data suggest two phases of late stage dolomitization, the first resulting from intraformational waters warmed by burial, and the second from warm basin derived brines.
An ecological model for health, illness and medicine: Pathogenesis and healing as self-organising processes in semiotic biofields
Creators: name: Aiken, Emma
Publisher: name: Swinburne
Year: 2024

description: This research draws upon process philosophy and complexity-oriented biology to propose an alternative to the mechanistic/reductionist paradigm dominating medicine. The ecological model conceives disease in terms of entrained responses to felt needs (or problems) and healing in terms of the reconfiguration of these responses towards a coherent response of the whole person. The model is compared with existing psychotherapies and holistic medicine that understand mind and body as a coherent field, and employ low-force interventions designed to prompt healing processes rather than control symptoms. The implications of the model for research and healthcare practices are discussed .
Privatisation et réforme pénale : la mise en place de la privatisation au sein du Service correctionnel du Canada de 1970 à nos jours.
Creators: name: Cardinal, Joanne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Political Science, Public Administration.

description: L'objet de cette etude est d'examiner la privatisation en tant que mouvement de reforme contemporain du domaine correctionnel. Plus specifiquement, nous avons observe et analyse la mise en place de la privatisation au sein du Service Correctionnel du Canada de 1970 a nos jours. C'est a la lumiere de ces propos que nous posons les questions suivantes: peut-on laisser entendre que la privatisation, en tant que mouvement de reformes contemporain du milieu carceral apportera des transformations d'importance a l'interieur des prisons? Est-ce que cet interet pour la privatisation des prisons signifie une remise en cause de cette institution dont la critique est contemporaine a son apparition? Est-ce que la privatisation des prisons telle que concue a l'heure actuelle peut permettre le developpement d'une nouvelle logique carcerale? Afin d'observer et d'analyser la mise en place de la privatisation en tant que mouvement de reforme de la prison nous avons utilise une approche methodologique inspiree de Conley (1984). Celle-ci distingue entre trois moments du changement penitentiaire: (1) sa conceptualisation; (2) sa rationalisation et sa structuration; et (3), son operationnalisation. C'est par l'entremise d'une analyse documentaire que nous avons mis en evidence le decalage qui s'opere entre les differents moments du changement penitentiaire et les consequences immediates de la privatisation sur l'environnement de la prison. Les resultats de notre analyse suggerent que la privatisation des prisons n'apporte pas des transformations importantes au milieu carceral dans la mesure ou les reformes actuelles qui sous-tendent la privatisation se lient toujours a la logique disciplinaire. A cet egard, nous soutenons que les reformes "privatisantes" ont plutot pour consequence de disperser la logique disciplinaire dans la sphere du social. (Abstract shortened by UMI.)
Flux line interactions in conventional and high critical transition temperature superconductors.
Creators: name: Lalonde, Richard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Physics, Electricity and Magnetism.

description: We have developed a novel experimental approach for the study of the interaction of sheets of non parallel flux lines in hysteric type II superconductors. We continuously monitor the evolution of the components of the magnetic flux density $\Vert$ and $\perp$ to $H\sb{a}$ (i.e. $\langle B\sb{z}\rangle$ and $\langle B\sb{y}\rangle$) as $H\sb{a}$ is raised to various intensities, and then reduced to zero. In our investigation of a high $T\sb{c}(YBa\sb{2}Cu\sb{3}O\sb{7-x}$) ceramic, $H\sb{a}$ exceeded $H\sb{*}$, the first full penetration field. We applied the phenomenological Clem general critical state model to the analysis of our extensive observations. A computer program was developed to solve the four coupled differential equations of this theory with appropriate physical constraints for the situations prevailing in our experiment. This analysis provides detailed insight into the evolution of the intricate configurations of the magnetic flux density $\vec B$(x), the critical current density, $\vec J$(x), and electric field $\vec E$(x) patterns as the injected and trapped flux lines are made to interact, unpin, migrate and undergo flux cutting processes. The model is seen to generate the variety of complicated measured curves of $\langle B\sb{y}\rangle$ and $\langle B\sb{z}\rangle$ vs $H\sb{a}$ very satisfactorily. (Abstract shortened by UMI.)
Host plant association and evolution in a genus of specialist fruit flies
Creators: name: Hippee, Alaine C
Publisher: name: University of Iowa
Year: 2024
Subjects: public abstract
Entomology

description: The ecology of animals can shape their evolutionary histories. For specialist parasitic insects, whose environment is largely defined by their association with a specific host, interactions with hosts can mediate morphological, behavioral, or physiological changes, or even initiate speciation. In this dissertation, I use a genus of specialist fruit flies (Strauzia) to explore several ways in which the evolutionary histories of insects and host plants interact. First, using a reduced-representation genomic sequencing approach, I infer the first comprehensive phylogeny of genus Strauzia and demonstrate that Strauzia species have shifted onto the same plant hosts at least twice. Then, I compared wing morphologies in male and female flies across the genus and found that host plant sharing may influence the emergence of novel wing morphologies and sexual dimorphism, the latter a rare occurrence in the Tephritidae. Finally, I used collections of Strauzia longitudinalis from across North America to look for evidence of historical range expansion following the domestication of its plant host, Helianthus tuberosus, as part of the Eastern Agricultural Complex of indigenous agriculture in North America. Together, this work highlights the diversity of evolutionary questions that can be addressed by studying specialist insect species.
2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib
Creators: name: Gohlke, Bjoern-Oliver
name: Overkamp, Tim
name: Richter, Anja
name: Richter, Antje
name: Daniel, Peter T.
name: Gillissen, Bernd
name: Preissner, Robert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Drug action
subject: Drug discovery
subject: Polyadenylation
subject: Vascular endothelial growth factor (VEGF)
subject: 3D similarity landscapes
subject: Drug-discovery
subject: Vatalanib
subject: PARP
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Searching for two-dimensional (2D) structural similarities is a useful tool to identify new active compounds in drug-discovery programs. However, as 2D similarity measures neglect important structural and functional features, similarity by 2D might be underestimated. In the present study, we used combined 2D and three-dimensional (3D) similarity comparisons to reveal possible new functions and/or side-effects of known bioactive compounds. Results We utilised more than 10,000 compounds from the SuperTarget database with known inhibition values for twelve different anti-cancer targets. We performed all-against-all comparisons resulting in 2D similarity landscapes. Among the regions with low 2D similarity scores are inhibitors of vascular endothelial growth factor receptor (VEGFR) and inhibitors of poly ADP-ribose polymerase (PARP). To demonstrate that 3D landscape comparison can identify similarities, which are untraceable in 2D similarity comparisons, we analysed this region in more detail. This 3D analysis showed the unexpected structural similarity between inhibitors of VEGFR and inhibitors of PARP. Among the VEGFR inhibitors that show similarities to PARP inhibitors was Vatalanib, an oral “multi-targeted” small molecule protein kinase inhibitor being studied in phase-III clinical trials in cancer therapy. An in silico docking simulation and an in vitro HT universal colorimetric PARP assay confirmed that the VEGFR inhibitor Vatalanib exhibits off-target activity as a PARP inhibitor, broadening its mode of action. Conclusion In contrast to the 2D-similarity search, the 3D-similarity landscape comparison identifies new functions and side effects of the known VEGFR inhibitor Vatalanib.
A Vision for Coherent Israel Education: The Makom Matrix, The Right Angle Vector, and Diagonal Pedagogy
Creators: name: Weinberg, Aaron Wasserman
Publisher: name: Brandeis University
Year: 2015
Subjects: Israel Education
Makom
Makom Israel
Complexity
Right Angle Vector
Diagonal Pedagogy
Makom Matrix
Nuance

description: A popular philosophy of Israel education in North America has been predicated on the notion of “connection first, knowledge later.” Some common phrases that epitomize this philosophy are “love before learn” and “connection before complexity.” This thesis seeks to challenge the effectiveness of this approach, problematize its elements, and articulate an alternative coherent and holistic vision for Israel education that engages both in meaningful connections to Israel and deep understandings of Israel’s nuances.\r \r The Makom Matrix is an exceptionally instructive tool developed by Alex Sinclair, Robbie Gringras, Yonatan Ariel, Esti Moskowitz-Kalman, and other colleagues at Makom Israel. The Matrix both helps map the challenges with the sequential connection or love-first approach, and aids in demonstrating a coherent and holistic vision of Israel education through proportional diagonal pedagogy.\r \r The sequential connection or love-first approach is captured by a framework coined the Right Angle Vector approach. Cases of published press pieces written North America Jews reflecting on their Israel Educational experiences illuminate the framework.\r \r TaNaKh education and the role of teaching biblical criticism, through the case studies provided and vision articulated in Susan Tanchel’s work, serve as a powerful comparison and proof of concept. \r \r Finally, an original paradigm of Israel education is presented, of the three C’s: connected, compelling, and complex. This new model is offered as a tool to aid in better achieving proportional diagonal pedagogy as part of a coherent and holistic vision for Israel education.
Architectural knowledge integration in a social innovation context
Creators: name: Mo, John P. T.
name: Beckett, Ronald
Publisher: name: Swinburne
Year: 2024

description: In an earlier study we had noted that the term transdisciplinary is used in describing a number of different situations, but always implied some form of knowledge-sharing collaboration. Researchers have observed that the requisite knowledge lies both within a development team and outside of it, but how it all works in harmony may vary from case to case. In this paper we explore the utility of a system architecture description standard, ISO 42010 as a framework for representing architectiral knowledge in a consistent way. This is illustrated in a social innovation case study. The case also illustrates how knowledge from social, medical and physical sciences was combined at multiple levels within a telemedicine delivery system.
Molecular Typing of Somatic Coliphage Groups and Their Occurrence and Survival in Sewage
Creators: name: Bailey, Emily S.
name: Sobsey, Mark D.
name: Chemla, Jeremy
name: Randall, Thomas A.
name: Lee, Heesuk
Publisher: name: MDPI
Year: 2024

description: A conventional, group-specific PCR method was developed to identify each of the four previously defined major taxa (Myoviridae, Siphoviridae, Podoviridae and Microviridae) of somatic coliphages and used to classify isolates from sewage. Somatic coliphage infectivity detection, occurrence and survival in primary human sewage effluent was observed over time to further understand the presence and behavior of the groups of somatic coliphages at two environmental temperatures (4 and 25 °C). Over time, the taxonomic composition of the somatic coliphage population in sewage changed, with the Microviridae family becoming the most prevalent family in the sewage population after several weeks. Based on their persistence and prevalence in environmental waters, phages belonging to the Microviridae family provide supporting information on sewage contamination and possibly of human enteric viruses in sewage-contaminated water.
Kitsap County 4-H Newsletter, September 2019
Creators: name: Washington State University Kitsap County Extension
Publisher: name: Washington State University
Year: 2019

description: Contents:
description: Important Dates
description: In the Spotlight
description: What's Happening in 4-H in Kitsap County
description: State~National~International 4-H Opportunities
description: 4-H Fundraisers
description: Scholarship Opportunities
description: Volunteer News
description: 4-H Trivia
description: 4-H Office Contact Information
Clinical benefit of improved Prehospital stroke scales to detect stroke patients with large vessel occlusions: results from a conditional probabilistic model
Creators: name: Schlemm, Ludwig
name: Schlemm, Eckhard
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Ischemic stroke
subject: Endovascular treatment
subject: Thrombectomy
subject: Thrombolysis
subject: Prehospital triage
subject: Emergency medical services
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background: Clinical scales to detect large vessel occlusion (LVO) may help to determine the optimal transport destination for patients with suspected acute ischemic stroke (AIS). The clinical benefit associated with improved diagnostic accuracy of these scales has not been quantified. Methods: We used a previously reported conditional model to estimate the probability of good outcome (modified Rankin scale sore ≤2) for patients with AIS and unknown vessel status occurring in regions with greater proximity to a primary than to a comprehensive stroke center. Optimal rapid arterial occlusion evaluation (RACE) scale cutoff scores were calculated based on time-dependent effect-size estimates from recent randomized controlled trials. Probabilities of good outcome were compared between a triage strategy based on these cutoffs and a strategy based on a hypothetical perfect LVO detection tool with 100% diagnostic accuracy. Results: In our model, the additional benefit of a perfect LVO detection tool as compared to optimal transport-time dependent RACE cutoff scores ranges from 0 to 5%. It is largest for patients with medium stroke symptom severity (RACE score 5) and in geographic environments with longer transfer time between the primary and comprehensive stroke center. Conclusion: Based on a probabilistic conditional model, the results of our simulation indicate that more accurate prehospital clinical LVO detections scales may be associated with only modest improvements in the expected probability of good outcome for patients with suspected acute ischemic stroke and unknown vessel status.
Visible Light-based Stereolithography Bioprinting of Cell-adhesive Gelatin Hydrogels
Creators: name: Wang, Zongjie
name: Tian, Zhenlin
name: Jin, Xian
name: Holzman, Jonathan
name: Menard, Frederic
name: Kim, Keekyoung
Publisher: name: IEEE
Year: 2021

description: Stereolithography-based bioprinting offers advantages in resolution and rapid printing time, and thus has received major attention in recent years. However, traditional stereolithography-based bioprinting utilizes a ultraviolet light which may cause mutagenesis and carcinogenesis of cells. In this paper, we present a new visible light crosslinkable bioink that is based on cell-adhesive gelatin. The bioink consists of Eosin Y (EY) based photoinitiator and gelatin methacrylate (GelMA) pre-polymer solution. We examined the feasibility of using visible light from a commercial beam projector to pattern the EY-GelMA bioink. We measured the absorbance of bioink to characterize its sensitivity to visible light and performed bioprinting to test its ability to promote cell adhesion. It is found that the EY-GelMA bioink has an absorption peak at roughly 522 nm and that it can be successfully crosslinked by visible light from the commercial projector. We performed the bioprinting experiments and visualized the cell morphology using nuclei/F-actin staining. Experimental results show that most of the cells attached to the EY-GelMA bioink after five days’ culturing. Ultimately, the EY-GelMA bioink can support both visible light crosslinking and cell adhesion, offering great potential in bioprinting and tissue engineering.
Impact of multipath clustering on correlation and MIMO system performance in Rayleigh fading channels
Creators: name: Zhao, Guangze
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Electronics and Electrical.

description: This thesis extends single cluster of multipath channel model to multi-cluster one. This multi-cluster channel model, which is more accurate than single cluster, has a profound effect on MIMO channel correlation and system performances. Based on this multi-cluster channel model, closed-form expressions of channel correlation are derived. The results using multi-cluster channel model agree with those using single cluster one. The results of the derived equations are also in full agreement with the results obtained from Monte-Carlo simulations. Using two-cluster channel model, the MIMO channel correlation coefficient has an oscillatory behavior with respect to the antenna spacing. Besides the angular spread and mean angle of arrival of the 2nd cluster, the power allocation has a significant effect on MIMO channel correlation. Similar to the behavior of channel correlation, both the MIMO channel capacity and diversity gain also oscillates with respect to the antenna spacing because of the 2nd cluster. It is also demonstrated that it is possible to orient the antenna array in such a way that the correlation is minimized and the maximum capacity can be achieved provided that the minimum element spacing is respected.
The role of peer victimization in the physical activity and screen time of adolescents: a cross-sectional study
Creators: name: Stearns, Jodie A.
name: Carson, Valerie
name: Spence, John C.
name: Faulkner, Guy E. J., 1970-
name: Leatherdale, Scott T.
Publisher: name: BioMed Central
Year: 2017

description: Background: Negative peer experiences may lead adolescents with overweight and obesity to be less active and engage in more sitting-related behaviors. Our study is among the first to empirically test these associations and hypothesized that 1) peer victimization would mediate the negative association between body weight status and moderate-to-vigorous physical activity (MVPA), and 2) peer victimization would mediate the positive association between body weight status and screen time. Differences by gender were also explored. Methods: Participants were a part of the Year 1 data (2012–2013) from the COMPASS study, a prospective cohort study of high school students in Ontario and Alberta, Canada. The final sample consisted of 18,147 students in grades 9 to 12 from 43 Ontario secondary schools. The predictor variable was weight status (non-overweight vs. overweight/obese), the mediator was peer victimization, and the outcome variables were screen time and MVPA. Multilevel path analysis was conducted, controlling for clustering within schools and covariates. A few differences were observed between males and females; therefore, the results are stratified by gender. Results: For both males and females peer victimization partially mediated the association between weight status and screen time. Specifically, females with overweight/obesity reported 34 more minutes/day of screen time than did females who were not overweight and 2 of these minutes could be attributed to experiencing peer victimization. Similarly, males who were overweight/obese reported 13 more minutes/day of screen time than the males who were not overweight and 1 of these minutes could be attributed to experiencing more victimization. Males and females who were overweight/obese also reported less MVPA compared to those who were not overweight; however, peer victimization did not mediate these associations in the hypothesized direction. Conclusions: We found that higher rates of peer victimization experienced by adolescents with overweight and obesity partially explained why they engaged in more screen time than adolescents who were not overweight. However, the effects were small and may be of limited practical significance. Because this is one of the first studies to investigate these associations, more research is needed before bully prevention or conflict resolution training are explored as intervention strategies.
Evolution of performance imagery among elite team-sport professionals from former communist Romania.
Creators: name: Diaconescu, Andy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Anthropology, Cultural.

description: In-depth interviews were conducted with eight European life-long sport professionals who were former elite athletes and then successful coaches in team sports. The purpose of the interview was to explore the role and the evolution of imagery from athlete to coach and to also determine whether mental imagery was used in any way by these professional coaches for enhancing team unity. Analysis showed that all these exceptional performers had excellent imagery skills and they used imagery training to achieve their sport related goals. Practical implications for enhancing team unity through imagery are also presented.
Kitsap County 4-H Newsletter, May 2020
Creators: name: Washington State University Kitsap County Extension
Publisher: name: Washington State University
Year: 2020
Subjects: 4-H Club

description: Contents:
description: Important Dates
description: Extension Notes
description: In the Spotlight
description: 4-H in Kitsap County
description: State & National 4-H Opportunities
description: 4-H Fundraisers
description: Scholarship Opportunities
description: Volunteer News
description: 4-H Office Contact Information
Postoperative anatomical and functional outcomes of different stages of high myopia macular hole
Creators: name: Shao, Qing
name: Xia, Huijuan
name: Heussen, Florian M. A.
name: Ouyang, Yanling
name: Sun, Xiaodong
name: Fan, Ying
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Recently it was suggested that high myopia macular holes (HMMH) and macular holes accompanied by retinal detachment occur in the advanced stages of myopia traction maculopathy (MTM), while macular retinoschisis, shallow retinal detachment without holes, and lamellar macular holes occur in the early stages of MTM. Complete vitreous cortex removal associated with internal limiting membrane peeling is now widely used to treat HMMH. However, it remains uncertain at what HMMH stage patients would benefit most from surgical intervention. Our study was aimed to evaluate the postoperative anatomical changes and functional outcomes of high myopia macular holes (HMMH). Methods Patients were retrospectively collected between March 2009 and August 2011. Before and 1st, 3rd, and 9th month after 23G pars plana vitrectomy, all patients underwent a complete ophthalmologic examination, spectral domain optical coherence tomography (SD-OCT) and MP-1. At each follow-up, best- corrected visual acuity (BCVA), photoreceptor inner and outer segments (IS/OS) defects, and retinal sensitivity (RS) were investigated. According to different preoperative macular hole morphologies, patients were divided into three groups: Group 1, macular hole with epiretinal membrane (ERM) traction and macular retinoschisis; Group 2, full-thickness macular hole (FTMH); Group 3, FTMH with subretinal fluid. Results 43 eyes from 43 patients met the inclusion criteria. The mean age was 60 years. BCVA and RS were significantly improved after vitrectomy; the mean IS/OS defect was significantly reduced. At 9 postoperative months, 11 of 43 (25.6 %) eyes achieved IS/OS junction integrity; 9 of these 11 (81.8 %) eyes belonged to Group 1, 2 (18.2 %) belonged to Group 2. Conclusions Pars plana vitrectomy combined with ILM peeling and gas tamponade results in limited functional outcomes in patients with HMMH. The appearance of subretinal fluid indicates a worse prognosis for surgical intervention.
Redefining Self-Sufficiency for Refugee Integration in the United States
Creators: name: Finney, Brittany
Publisher: name: Brandeis University
Year: 2018
Subjects: refugee
integration
self-sufficiency

description: Due to the increasing prevalence of political violence in developing countries such as Syria and Myanmar, the acceptance and integration of refugees has become a pressing issue in international discourse today. Unlike most countries, the United States resettlement programs are designed to permanently incorporate refugees to become naturalized citizens. The primary objective is to help refugees achieve self-sufficiency. Although United States refugee resettlement programs have claimed that they have helped 82% of their refugees become self-sufficient, the definition of self-sufficiency and how it is measured misrepresents the integration outcomes of refugees. I argue that a bottom-up definition of self-sufficiency that incorporates economic, psychological, and social aspects is necessary in program implementation. Using scholarly research, national and international datasets, and definitions of self-sufficiency employed in other countries, this paper both analyzes the limitations of the traditional model of self-sufficiency and offers remedies as to how a bottom-up model of self-sufficiency could improve refugee integration. By incorporating a model that acknowledges self-sufficiency as a process of interdependency, this paper supports an improved model for refugee integration as a whole.
Le traitement de résistances intrapsychiques par la technique de l'imagerie mentale : (une étude phénoménologique)
Creators: name: Doiron, Viola.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Psychology, Clinical.

description: L'approche de l'imagerie bipolaire de Ashen (1978) a laquelle furent integres des elements de l'approche de Gendlin (1984) et de Grinder et Bandler (1982), est proposee comme traitement pour resoudre la polarite percue par un ensemble de chercheurs comme constituante de la resistance intrapsychique. L'experience a ete prealablement tentee par deux therapeutes, maitrisant cette approche, aupres de trois sujets ages de 40 a 65 ans. La methode phenomenologique a permis de recuperer la subjectivite du processus vecu et d'analyser le phenomene de maniere a en saisir la structure essentielle. Les resultats indiquent une resolution efficace de la resistance intrapsychique particuliere eprouvee par chacun des sujets ainsi qu'un acces durable a une plus grande autonomie. De plus, bien que chaque experience ait ete distincte, les resultats laissent entrevoir des themes recurrents dans les divers processus: reference kinesthesique persistante; emergence d'interdits parentaux ou d'enjeux de controle; decouverte de sens nouveaux quant au monde interieur du sujet et a son mode relationnel. L'etude se termine par une discussion de ces resultats et une reflexion pastorale en lien avec les conclusions de l'analyse effectuee. De l'exploration de ces resultats decoule l'espoir qu'une theorie psychologique de l'imagerie mentale soutienne une pratique transformante qui rendra l'intervention therapeutique plus profondement satisfaisante et pour le client et pour le therapeute.
Mycobacterium abscessus pulmonary infection and associated respiratory function in cystic fibrosis-like βENaC mice
Creators: name: Pearce, Camron M.
name: Hickey, Anthony J.
name: Livraghi-Butrico, Alessandra
name: Henao-Tamayo, Marcela
name: Gonzalez-Juarrero, Mercedes
name: Jackson, Mary
name: Lam, Ha
name: Obregon-Henao, Andres
name: Shaw, Timothy D.
name: O'Neal, Wanda
name: Podell, Brendan
name: Meibohm, Bernd
name: Alshiraihi, Ilham M.
Publisher: name: Frontiers Media SA
Year: 2024

description: Introduction Chronic pulmonary infection with Mycobacterium abscessus (M. abscessus) is a significant cause of morbidity and mortality in people with cystic fibrosis (CF). Developing an animal model of M. abscessus pulmonary infection, especially under CF conditions, is essential to understanding clinical pulmonary M. abscessus infection. βENaC transgenic mice are known to develop spontaneous CF-like disease characterized by airway mucus obstruction and inflammation. The aim of this study was to evaluate the suitability of βENaC mice as a preclinical model and characterize their respiratory function during M. abscessus lung infection. Methods Mice received an intrapulmonary aerosol of M. abscessus using a high-pressure syringe device (Penn-Century) for subsequent characterization of disease progression and respiratory function. Whole body unrestrained plethysmography (WBP) data was collected to monitor lung function and endpoints determined organ bacterial burden and associated pathology. Results Endpoint CFU data in the lung and spleen showed that there was no significant difference in bacterial clearance between βENaC and WT mice. WBP data showed an impairment in overall respiratory function during and after M. abscessus infection in both strains of mice. Interestingly, even in wildtype control mice, lung dysfunction persisted after bacterial clearance. Discussion Even with CF-like features, the βENaC transgenic mice cleared M. abscessus at a similar rate than WT mice, however, the associated respiratory monitoring revealed that there are long-term implications of M. abscessus lung exposure. The clear decline in respiratory function, even after M. abscessus clearance, suggests that WBP coupled animal modeling provides important insight that is relevant to disease burden and treatment efficacy. The M. abscessus clearance in the βENaC mice may help improve the fields understanding of CF-modulated immune deficiencies in M. abscessus pulmonary infection.
High-Resolution Mechanical Imaging of Glioblastoma by Multifrequency Magnetic Resonance Elastography
Creators: name: Streitberger, Kaspar-Josche
name: Reiss-Zimmermann, Martin
name: Freimann, Florian Baptist
name: Bayerl, Simon
name: Guo, Jing
name: Arlt, Felix
name: Wuerfel, Jens
name: Braun, Jürgen
name: Hoffmann, Karl-Titus
name: Sack, Ingolf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective To generate high-resolution maps of the viscoelastic properties of human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB). Methods Twenty-two GB patients underwent routine presurgical work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional viscoelastic parameter maps, magnitude |G*|, and phase angle φ of the complex shear modulus were reconstructed by inversion of full wave field data in 2-mm isotropic resolution at seven harmonic drive frequencies ranging from 30 to 60 Hz. Results Mechanical brain maps confirmed that GB are composed of stiff and soft compartments, resulting in high intratumor heterogeneity. GB could be easily differentiated from healthy reference tissue by their reduced viscous behavior quantified by φ (0.37±0.08 vs. 0.58±0.07). |G*|, which in solids more relates to the material's stiffness, was significantly reduced in GB with a mean value of 1.32±0.26 kPa compared to 1.54±0.27 kPa in healthy tissue (P = 0.001). However, some GB (5 of 22) showed increased stiffness. Conclusion GB are generally less viscous and softer than healthy brain parenchyma. Unrelated to the morphology-based contrast of standard magnetic resonance imaging, elastography provides an entirely new neuroradiological marker and contrast related to the biomechanical properties of tumors.
Sustainable Farming Quarterly, April 1991
Creators: name: Granatstein, David
Publisher: name: Washington State University
Year: 1991
Subjects: Agriculture

description: Grass: using nature's way of building the soil / Farm Bill recognizes benefits of sustainable farming techniques / On-farm testing gives first-hand results / On-farm test number cruncher doesn't require computer genius / Farmer case studies will provide more firsthand data / Sustainable-farming database debuts
Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator
Creators: name: Micklisch, Sven
name: Lin, Yuchen
name: Jacob, Saskia
name: Joussen, Antonia M. [U. V. M.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443ins54), the latter inducing mRNA instability. At present, the function of the ARMS2 protein, the exact cellular sources in the retina and the biological consequences of the rs10490924 polymorphism are unclear. Methods Recombinant ARMS2 was expressed in Pichia pastoris, and protein functions were studied regarding cell surface binding and complement activation in human serum using fluoresence-activated cell sorting (FACS) as well as laser scanning microscopy (LSM). Biolayer interferometry defined protein interactions. Furthermore, endogenous ARMS2 gene expression was studied in human blood derived monocytes and in human induced pluripotent stem cell- derived microglia (iPSdM) by PCR and LSM. The ARMS2 protein was localized in human genotyped retinal sections and in purified monocytes derived from AMD patients without the ARMS2 risk variant by LSM. ARMS2 expression in monocytes under oxidative stress was determined by Western blot analysis. Results Here, we demonstrate for the first time that ARMS2 functions as surface complement regulator. Recombinant ARMS2 binds to human apoptotic and necrotic cells and initiates complement activation by recruiting the complement activator properdin. ARMS2-properdin complexes augment C3b surface opsonization for phagocytosis. We also demonstrate for the first time expression of ARMS2 in human monocytes especially under oxidative stress and in microglia cells of the human retina. The ARMS2 protein is absent in monocytes and also in microglia cells, derived from patients homozygous for the ARMS2 AMD risk variant (rs10490924). Conclusions ARMS2 is likely involved in complement- mediated clearance of cellular debris. As AMD patients present with accumulated proteins and lipids on Bruch’s membrane, ARMS2 protein deficiency due to the genetic risk variant might be involved in drusen formation.
Science et idéologie : criminologie québécoise et contexte politico-pénal canadien.
Creators: name: Dufresne, Martin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Sociology, Criminology and Penology.

description: Au Canada, de l'institutionnalisation des sciences sociales au cours des années 1950 et 1960, naîtront une série de disciplines hybrides, croisant des savoirs déjà constitués répondant a des besoins de spécialisation provoqués, entre autres choses, par l'expansion de l'appareil d'État. La criminologie émerge comme discipline scientifique dans ce contexte. Le criminologue s'inspire du médecin-curateur, remenant la "criminalité" a un quelconque virus qui circulerait surtout au travers les couches les plus defavorisées de la société. Ce travail de recherche se propose d'analyser le discours criminologique en le considerant comme une institution. Il s'agit de reconstituer l'institutionnalisation de la criminologie québécoise dans le contexte politico-pénal canadien, de manière à en faire ressortir les conditions de production. Hypostasier la notion de crime permet d'évacuer l'aspect politique des définitions de crime. La criminologie créé le "criminel" et le "comportement criminel" comme entités existantes, vraies. En voulant synthétiser en un savoir eclectique des approches singulières, la criminologie ne cherche pas a réfléchir et théoriser sur le phénomène du crime, elle cherche à expliquer un "mal" déjà conjure par le droit et la morale. (Abstract shortened by UMI.)
Feature interaction filtering and detection with use case maps and LOTOS.
Creators: name: Hassine, Jameleddine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Computer Science.

description: Telephony systems have evolved from the Plain Old Telephony System providing only the basic functionality of making phone calls, to sophisticated systems in which many features have been introduced, providing network subscribers more control on the call establishment process. However, these facilities are confronted with a major obstacle known as the feature interaction problem. A feature interaction occurs when at least one feature is prevented from performing its functionality or when the system functions incorrectly due to the presence of features. In the first part of the thesis, we present a model for describing telephony features at the requirements stage. This model is built using the Use Case Maps Notation (UCM). Based on this model, we propose a method to filter feature interactions at the requirements stage. This preliminary evaluation allows the detection process to focus on feature combinations where interactions are possible and therefore reduces the cost of the detection process. In the second part of the thesis, a Feature Interaction Detection System is developed for detecting feature interactions between switch based and IN features. This method aims to detect interactions occurring at the abstract specification level and resulting in violation of feature properties. This technique in based on the Formal Description technique LOTOS and uses Abstract Data Types to detect those violations. Our method detects feature interaction by executing the system specification. The designer can reach those interaction points either by a step by step execution or using the goal oriented execution technique. It is concluded that UCM and LOTOS are useful in specifying the telephony system with features and for detecting feature interactions at the abstract specification level.
An in-store assessment of consumers’ Willingness-To-Pay for organic apples: Does size matter?
Creators: name: Granatstein, David
name: Skuza, Nate
name: Ellis, Joan
name: MCCRACKEN, VICKI A
Publisher: name: Washington State University
Year: 2010
Subjects: organic apple
Consumer Behavior

description: Organic food sales in the U.S. have grown about 20% annually, from $3.6 to over $21b, between 1997 and 2008 (Organic Trade Association, 2006) . The demand for organic food exceeds supply despite increases in U.S. and Washington State certified acreage and increases in imports of organic food. Organic premiums remain at the farm gate and retail levels. Larger organic producers are filling market demands, accounting for a growing share of total organic sales (84% of total market by 2006 - Granatstein and Kirby). Consumers have demonstrated a willingness-to-pay (WTP) a premium for organics but high premiums may deter additional market growth. This study assesses consumers WTP for two distinct sizes of certified organic-labeled WA XF Fuji apples using an auction mechanism at the point of purchase (in grocery stores) in Spokane WA in March 2010. The results indicate that consumers are willing to pay more for larger sized and organically produced Fuji apples, but the amount that consumers were WTP was impacted by consumer demographics and preferences.
Memasuki Era "New Normal COVID-19": SARS-CoV-2 Occupational Safety and Health Standard in Germany
Creators: name: Bockmeyer, Andina
name: IASI, Jerman
Publisher: name: Zenodo
Year: 2020
Subjects: COVID-19
New Normal
Webinar IASI
Pengalaman Jerman
Standard Keselamatan dan Kesehatan

description: Sejak tanggal 4 mei 2020 lalu, pemerintah jerman memberlakukan pelonggaran kebijakan Lockdown/PSBB atau Pembatasan Sosial Berskala Besar secara nasional, Akan tetapi, pemerintah Jerman menekankan bahwa pembatasan sosial harus diberlakukan kembali jika jumlah infeksi baru naik di atas ambang batas tertentu.
 Bagaimana Protokol atau persyaratan2 yang harus dipenuhi oleh para pengusaha jerman tersebut, nanti akan dipaparkan oleh Dr. med. Andina Bockmeyer. Dan bagaimana keadaan dan penanganan pasien di RS jerman di saat pandemi sebelum dan sesudah pelonggaran psbb, akan dipaparkan oleh dr. I Putu Widhi Yuda Yadnya.