cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Germs of arcs on singular algebraic varieties and motivic integration
Creators: name: Denef, J.
name: Loeser, F.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14A15; 14B05; 32S05; 32S45; 03C10

description: We study the scheme of formal arcs on a singular algebraic variety and its images under truncations. We prove a rationality result for the Poincare series of these images which is an analogue of the rationality of the Poincare series associated to p-adic points on a p-adic variety. The main tools which are used are semi-algebraic geometry in spaces of power series and motivic integration (a notion introduced by M. Kontsevich). In particular we develop the theory of motivic integration for semi-algebraic sets of formal arcs on singular algebraic varieties, we prove a change of variable formula for birational morphisms and we prove a geometric analogue of a result of Oesterle.
description: Revised Nov. 1997, to appear in Inventiones Mathematicae, 27 pages
PoD-TPI: Probability-of-Decision Toxicity Probability Interval Design to Accelerate Phase I Trials
Creators: name: Zhou, Tianjian
name: Guo, Wentian
name: Ji, Yuan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Cohort-based enrollment can slow down dose-finding trials since the outcomes of the previous cohort must be fully evaluated before the next cohort can be enrolled. This results in frequent suspension of patient enrollment. The issue is exacerbated in recent immune-oncology trials where toxicity outcomes can take a long time to observe. We propose a novel phase I design, the probability-of-decision toxicity probability interval (PoD-TPI) design, to accelerate phase I trials. PoD-TPI enables dose assignment in real-time in the presence of pending toxicity outcomes. With uncertain outcomes, the dose assignment decisions are treated as a random variable, and we calculate the posterior distribution of the decisions. The posterior distribution reflects the variability in the pending outcomes and allows a direct and intuitive evaluation of the confidence of all possible decisions. Optimal decisions are calculated based on 0-1 loss, and extra safety rules are constructed to enforce sufficient protection from exposing patients to risky doses. A new and useful feature of PoD-TPI is that it allows investigators and regulators to balance the trade-off between enrollment speed and making risky decisions by tuning a pair of intuitive design parameters. Through numerical studies, we evaluate the operating characteristics of PoD-TPI and demonstrate that PoD-TPI shortens trial duration and maintains trial safety and efficiency compared to existing time-to-event designs.
Identification of the potential biological target of N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline compounds active against gram-positive and gram-negative bacteria
Creators: name: Martinez, Sol R.
name: Pavani, Christiane C.
name: Baptista, Mauricio S.
name: Becerra, María C.
name: Quevedo, Mario A.
name: Ribone, Sergio R.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The development of new antibiotics with activity towards a broad spectrum of bacteria, including multiresistant strains, is a very important topic for global public health. As part of previous works, N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline (BSTHQ) derivatives were described as antimicrobial agents active against gram-positive and gram-negative pathogens. In this work, experimental and molecular modelling studies were performed in order to identify their potential biological target in the light of structure-based design efforts towards further BSTHQ derivatives. First, a carboxyfluorescein leakage assay was performed using liposomes to mimic bacterial membranes, which found no significative membrane disruption effects with respect to control samples. These results support a non-surfactant antimicrobial activity of the tested compounds. In a second stage, the inhibition of potential antimicrobial targets was screened using molecular modelling methods, taking into account previously reported druggable targets deposited in the ChEMBL database for Escherichia coli and Staphylococcus aureus. Two enzymes, namely D-glutamic acid-adding enzyme (MurD) and N-acetylglucosamine-1-phophate-uridyltransferase (GlmU), both involved in bacterial membrane synthesis, were identified as potential targets. Pharmacodynamic interaction models were developed using known MurD and GlmU inhibitors by applying state-of-the-art chemoinformatic methods (molecular docking, molecular dynamics and free energy of interaction analyses). These models were further extended to the analysis of the studied BSTHQ derivatives. Overall, our results demonstrated that the studied BSTHQ derivatives elicit their antibacterial activity by interacting with a specific molecular target, GlmU being the highly feasible one. Based on the presented results, further structure-aided design efforts towards the obtaining of novel BSTHQ derivatives are envisioned. Communicated by Ramaswamy H. Sarma
title: Marjorie Barstow, John Dewey and the Alexander Technique: A philosophical constellation, or “Variations of the Teacher’s Art”
Creators: name: Cole, Amanda Jane
Publisher: name: Griffith University
Year: 2016
Subjects: subject: Marjorie Barstow
subject: John Dewey
subject: F. Matthias Alexander
subject: Alexander technique
subject: Educational theories
subject: Music teaching

description: This project examines one strand of Alexander Technique1 pedagogy: the approach pioneered by the noted American Alexander teacher, Marjorie Barstow, the first graduate of F. Matthias Alexander’s training course. Barstow’s approach is favoured by performers because of its immediate and direct application to real and challenging situations. At the end of her life, from the 1970s to the early 1990s, she attracted thousands of students to her workshops, and many of her long-term students have since become world-renowned teachers themselves. Barstow’s detractors have argued, however, that because her teaching and teacher-training methods varied from mainstream approaches, she neither taught the Alexander Technique nor trained teachers. This opinion assumes a limited and even tendentious approach to interpreting Alexander’s legacy. One reason for the contrary opinion is the failure to view Alexander’s Technique in a wider intellectual and pedagogical context. I address this problem by situating Barstow’s pedagogy in the context of educational and philosophical theories being developed contemporaneously with and in line with Alexander’s own discoveries, theory and pedagogy. In particular, Barstow’s work is examined in relation to the “pragmatic” turn inphilosophy observable in the thought of John Dewey, who involved himself directly with the Alexander Technique and its founder. I consider Barstow, Dewey and F.M. Alexander for the first time as educationalists, practitioners and thinkers who are linked by a common concern with the pragmatic ends of philosophy.
Pseudolycoriella koreensis
Creators: name: Menzel, Frank
name: Smith, Jane E.
name: Chandler, Peter J.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sciaridae
Pseudolycoriella
Pseudolycoriella koreensis

description: PSEUDOLYCORIELLA KOREENSIS    (MOHRIG & MENZEL, 1992)
New to British list.
 Material examined: Stokeford Heath, Dorset, 1 male, 20.v.2001, Gibbs leg. (PDGB).
 Ecological notes: found on sandy heathland. v.
description: Published as part of Menzel, Frank, Smith, Jane E. & Chandler, Peter J., 2006, The sciarid fauna of the British Isles (Diptera: Sciaridae), including descriptions of six new species, pp. 1-147 in Zoological Journal of the Linnean Society 146 (1) on page 118, DOI: 10.1111/j.1096-3642.2006.00190.x, http://zenodo.org/record/5435693
Solar Neutrino Precision Measurements using all 1496 Days of Super-Kamiokande-I Data
Creators: name: Smy, M. B.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The results of the entire Super-Kamiokande-I solar neutrino data are presented. The measured interaction rate is 47+-2% of the rate expected by the standard solar model and 133+-5% of the rate implied by the SNO charged-current interaction rate. There is no evidence for spectral distortion or a time dependent neutrino flux. Together with the rates of other experiments, the Super-Kamiokande results imply active solar neutrino oscillations and restrict neutrino mixing and mass square difference to lie within the LMA solution area.
description: to be published in the Proceedings of the XXth International Confernece on Neutrino Physics and Astrophysics 8 pages, 11 figures
Cellular Response to Membrane Phospholipid Imbalance, in Yeast and in Human Disease
Creators: Vevea, Jason D.
Publisher: name: Columbia University
Year: 2015
Subjects: Mitochondria
Endoplasmic reticulum
Pathology, Cellular
Cell organelles
Cytology
Pathology

description: Organelles sequester biological phenomena within the cell, and allow an additional layer of complexity to life.  The presence and maintenance of these organelles is crucial for cellular function.  Two of the most expansive and complex organelles are the mitochondria and endoplasmic reticulum.  These organelles contribute energy, protein folding and secretion, lipids, calcium regulation, and various other metabolites to the biology of the cell.  Importantly, these organelles accumulate damage and cannot be derived de novo, therefore must be inherited and maintained in a functioning state.  The study of these organelle quality control processes serves as the basis for my thesis.
      	We use the budding yeast as a model organism to uncover conserved pathways affecting organelle, and ultimately cellular homeostasis.  In yeast we find mitochondrial inheritance is critical for cell survival.  Furthermore, not only is inheritance critical, but inheritance of a certain threshold of functional mitochondria appears critical in maintaining normal lifespan in yeast, identifying mitochondria as an aging determinant.
      	By examining mutants that negatively affect mitochondrial inheritance in yeast, we established a role for phosphatidylcholine biosynthesis in organelle maintenance and inheritance.  Glycerophospholipid biosynthesis plays a clear role not only in mitochondrial inheritance but also in that of the endoplasmic reticulum.  We use insights gained from yeast to guide research into a human disease caused by similar glycerophospholipid biosynthetic deficiency.
BFV-BRST analysis of equivalence between noncommutative and ordinary gauge theories
Creators: name: Dayi, Omer F.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Constrained hamiltonian structure of noncommutative gauge theory for the gauge group U(1) is discussed. Constraints are shown to be first class, although, they do not give an Abelian algebra in terms of Poisson brackets. The related BFV-BRST charge gives a vanishing generalized Poisson bracket by itself due to the associativity of *-product. Equivalence of noncommutative and ordinary gauge theories is formulated in generalized phase space by using BFV-BRST charge and a solution is obtained. Gauge fixing is discussed.
description: Minor changes, ref. added, to be pub. PLB
Photometric determination of the mass accretion rates of pre-main sequence stars. VI. The case of LH 95 in the Large Magellanic Cloud
Creators: name: Biazzo, Katia
name: Beccari, Giacomo
name: De Marchi, Guido
name: Panagia, Nino
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report on the accretion properties of low-mass stars in the LH95 association within the Large Magellanic Cloud (LMC). Using non-contemporaneous wide-band and narrow-band photometry obtained with the HST, we identify 245 low-mass pre-main sequence (PMS) candidates showing H$α$ excess emission above the 4$σ$ level. We derive their physical parameters, i.e. effective temperatures, luminosities, masses ($M_\star$), ages, accretion luminosities, and mass accretion rates ($\dot M_{\rm acc}$). We identify two different stellar populations: younger than ~8Myr with median $\dot M_{\rm acc}$~5.4x10$^{-8}M_\odot$/yr (and $M_\star$~0.15-1.8$M_\odot$) and older than ~8Myr with median $\dot M_{\rm acc}$~4.8x10$^{-9}M_\odot$/yr (and $M_\star$~0.6-1.2$M_\odot$). We find that the younger PMS candidates are assembled in groups around Be stars, while older PMS candidates are uniformly distributed within the region without evidence of clustering. We find that $\dot M_{\rm acc}$ in LH95 decreases with time more slowly than what is observed in Galactic star-forming regions (SFRs). This agrees with the recent interpretation according to which higher metallicity limits the accretion process both in rate and duration due to higher radiation pressure. The $\dot M_{\rm acc}-M_\star$ relationship shows different behaviour at different ages, becoming progressively steeper at older ages, indicating that the effects of mass and age on $\dot M_{\rm acc}$ cannot be treated independently. With the aim to identify reliable correlations between mass, age, and $\dot M_{\rm acc}$, we used for our PMS candidates a multivariate linear regression fit between these parameters. The comparison between our results with those obtained in other SFRs of our Galaxy and the MCs confirms the importance of the metallicity for the study of the $\dot M_{\rm acc}$ evolution in clusters with different environmental conditions.
description: Accepted for publication in ApJ; 26 pages, 12 pages, 3 tables; abstract shortened. Fixed a typo in the name of a co-author
Identification of the potential biological target of N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline compounds active against Gram-positive and Gram-negative bacteria
Creators: name: Martinez, Sol R.
name: Pavani, Christiane C.
name: Baptista, Mauricio S.
name: Becerra, María C.
name: Quevedo, Mario A.
name: Ribone, Sergio R.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The development of new antibiotics with activity towards a broad spectrum of bacteria, including multiresistant strains, is a very important topic for global public health. As part of previous works, N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline (BSTHQ) derivatives were described as antimicrobial agents active against Gram-positive and Gram-negative pathogens. In this work, experimental and molecular modelling studies were performed in order to identify their potential biological target in the light of structure-based design efforts towards further BSTHQ derivatives. First, a carboxyfluorescein leakage assay was performed using liposomes to mimic bacterial membranes, which found no significative membrane disruption effects with respect to control samples. These results support a non-surfactant antimicrobial activity of the tested compounds. In a second stage, the inhibition of potential antimicrobial targets was screened using molecular modelling methods, taking into account previously reported druggable targets deposited in the ChEMBL database for Escherichia coli and Staphylococcus aureus. Two enzymes, namely D-glutamic acid-adding enzyme (MurD) and N-acetylglucosamine-1-phophate-uridyltransferase (GlmU), both involved in bacterial membrane synthesis, were identified as potential targets. Pharmacodynamic interaction models were developed using known MurD and GlmU inhibitors by applying state-of-the-art chemoinformatic methods (molecular docking, molecular dynamics and free energy of interaction analyses). These models were further extended to the analysis of the studied BSTHQ derivatives. Overall, our results demonstrated that the studied BSTHQ derivatives elicit their antibacterial activity by interacting with a specific molecular target, GlmU being the highly feasible one. Based on the presented results, further structure-aided design efforts towards the obtaining of novel BSTHQ derivatives are envisioned.
Differences in long-term memory stability and AmCREB level between forward and backward conditioned honeybees (Apis mellifera)
Creators: name: Felsenberg, Johannes
name: Dyck, Yan
name: Feige, Janina
name: Ludwig, Jenny
name: Plath, Jenny Aino
name: Froese, Anja
name: Karrenbrock, Melanie
name: Nölle, Anna
name: Heufelder, Karin
name: Eisenhardt, Dorothea
Publisher: name: Freie Universität Berlin
Year: 2015
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: In classical conditioning a predictive relationship between a neutral stimulus (conditioned stimulus; CS) and a meaningful stimulus (unconditioned stimulus; US) is learned when the CS precedes the US. In backward conditioning the sequence of the stimuli is reversed. In this situation animals might learn that the CS signals the end or the absence of the US. In honeybees 30 min and 24 h following backward conditioning a memory for the excitatory and inhibitory properties of the CS could be retrieved, but it remains unclear whether a late long-term memory is formed that can be retrieved 72 h following backward conditioning. Here we examine this question by studying late long- term memory formation in forward and backward conditioning of the proboscis extension response (PER). We report a difference in the stability of memory formed upon forward and backward conditioning with the same number of conditioning trials. We demonstrate a transcription-dependent memory 72 h after forward conditioning but do not observe a 72 h memory after backward conditioning. Moreover we find that protein degradation is differentially involved in memory formation following these two conditioning protocols. We report differences in the level of a transcription factor, the cAMP response element binding protein (CREB) known to induce transcription underlying long- term memory formation, following forward and backward conditioning. Our results suggest that these alterations in CREB levels might be regulated by the proteasome. We propose that the differences observed are due to the sequence of stimulus presentation between forward and backward conditioning and not to differences in the strength of the association of both stimuli.
Statistics of correlation functions in the random Heisenberg chain
Creators: name: Colmenarez, Luis
name: McClarty, Paul A.
name: Haque, Masudul
name: Luitz, David J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Ergodic quantum many-body systems satisfy the eigenstate thermalization hypothesis (ETH). However, strong disorder can destroy ergodicity through many-body localization (MBL) -- at least in one dimensional systems -- leading to a clear signal of the MBL transition in the probability distributions of energy eigenstate expectation values of local operators. For a paradigmatic model of MBL, namely the random-field Heisenberg spin chain, we consider the full probability distribution of eigenstate correlation functions across the entire phase diagram. We find gaussian distributions at weak disorder, as predicted by pure ETH. At intermediate disorder -- in the thermal phase -- we find further evidence for anomalous thermalization in the form of heavy tails of the distributions. In the MBL phase, we observe peculiar features of the correlator distributions: a strong asymmetry in $S_i^z S_{i+r}^z$ correlators skewed towards negative values; and a multimodal distribution for spin-flip correlators. A quantitative quasi-degenerate perturbation theory calculation of these correlators yields a surprising agreement of the full distribution with the exact results, revealing, in particular, the origin of the multiple peaks in the spin-flip correlator distribution as arising from the resonant and off-resonant admixture of spin configurations. The distribution of the $S_i^zS_{i+r}^z$ correlator exhibits striking differences between the MBL and Anderson insulator cases.
description: 17 pages, 14 figures, corrected typos
Trichosia flavicoxa TUOMIKOSKI 1960
Creators: name: Menzel, Frank
name: Smith, Jane E.
name: Chandler, Peter J.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Dothideomycetes
Asterinales
Asterinaceae
Trichosia
Trichosia flavicoxa

description: TRICHOSIA FLAVICOXA TUOMIKOSKI, 1960
New to British and Irish list.
 Material examined: Burnham Beeches, Buckinghamshire, 3 males, 23.v.−7.vi.1995; 1 male, 27.x.− 7.xi.1995; 4 males, 28.v.−1.vii.1996; 2 males, 17.v.− 25.v.1999; 4 males, 1 female, 1.vi.−8.vi.1999, all Ismay leg. (HRI, PPCM). Frithsden Beeches, Hertfordshire, 1 male, 6.vi.1997, Chandler leg. (PPCM). Glasdrum, Argyll & Bute, 1 male, 12.vi.1976, Stubbs leg. (PPCM). Glen Coiltie, Highland Region, 1 male, 28.v.2002, Chandler leg. (PPCM). Loch Meiklie, Highland Region, 1 male, 13.vi.1984, Chandler leg. (NMS). Moccas Park, Herefordshire, 1 male, 11.vi.2002, Godfrey leg. (PPCM). River Flesk, Killarney, Kerry, 1 male, 8.vii.1989, Ashe leg. (NMID). Rotherfield Park, Hampshire, 1 male, 3.vii.2002, Chandler leg. (PPCM). Selborne Common, Hampshire, 1 male, 28.v.1988, Chandler leg. (PPCM). The Lythes, Selborne, Hampshire, 1 male, 28.v.1988, Chandler leg. (PPCM). Windsor Forest, Berkshire, 1 male, 15.v.1991, Chandler leg. (PPCM).
 Ecological notes: found in alder and other broadleaved woodland; ancient oak and beech forest; parkland. v–vii, x–xi.
description: Published as part of Menzel, Frank, Smith, Jane E. & Chandler, Peter J., 2006, The sciarid fauna of the British Isles (Diptera: Sciaridae), including descriptions of six new species, pp. 1-147 in Zoological Journal of the Linnean Society 146 (1) on page 138, DOI: 10.1111/j.1096-3642.2006.00190.x, http://zenodo.org/record/5435693
Motivic Igusa zeta functions
Creators: name: Denef, J.
name: Loeser, F.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14A15; 14A20; 14B05; 32S45; 32S05; 32S30; 32S35

description: We define motivic analogues of Igusa's local zeta functions. These functions take their values in a Grothendieck group of Chow motives. They specialize to p-adic Igusa local zeta functions and to the topological zeta functions we introduced several years ago. We study their basic properties, such as functional equations, and their relation with motivic nearby cycles. In particular the Hodge spectrum of a singular point of a function may be recovered from the Hodge realization of these zeta functions.
description: Revised September 1997, to appear in Journal of Algebraic Geometry, 34 pages
title: Development of a Valid and Reliable Measure of Paediatric Intensive Care Nursing Knowledge And Skills
Creators: name: Long, Deborah Amanda
Publisher: name: Griffith University
Year: 2012
Subjects: subject: Paediatric intensive care nursing
subject: Education in nursing practice
subject: Nursing education
subject: Nursing skills
subject: Nursing evaluation

description: Workplace learning and staff development for nurses are crucial for ongoing competence improvements in the quality of patient care. In particular, graduate nurses in specialty areas present unique challenges for nurse educators when designing orientation programs, evaluating learning and facilitating initial competence development. Identifying the learning needs of employees and evaluating the results of staff development are therefore essential elements of any nursing practice environment. However, instruments to evaluate nursing knowledge and skills in the Australian and New Zealand paediatric intensive care environment have been lacking. The purpose of this study was to construct and test the psychometric properties of a paediatric intensive care nursing knowledge and skills test; a multiple choice test for measuring the key nursing knowledge and skills required for safe, competent practice in Australia and New Zealand.
Additional file 2 of LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway
Creators: name: Fu, Dazhi
name: Ren, Yongjun
name: Wang, Chunxiao
name: Yu, Lei
name: Yu, Rui
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Supplementary Table 2. Differentially regulated mRNAs between colon cancer tissues (CC) vs paired normal samples.
Cellular and Molecular Mechanisms of Mammalian Touch-Dome Development
Creators: Jenkins, Blair Addison
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Biology
subject: Developmental biology
subject: Merkel cells
subject: Touch
subject: Neurobiology

description: Touch sensation is initiated by diverse mechanosensory neurons that innervate distinct skin structures; however, little is known about how touch receptors are patterned during mammalian skin development.  During the course of my PhD training, I analyzed embryonic and neonatal development of mouse touch domes, which contain Merkel cell-neurite complexes that encode pressure and object features.  I found that developing touch domes share three key features with canonical sensory placodes: discrete patches of specialized epithelial, co-clustered mesenchymal cells capable of engaging in molecular crosstalk with the epithelium, and selective recruitment of sensory neurons.  During embryogenesis, molecularly distinct patches of epithelial Merkel cells and keratinocytes clustered with a previously unsuspected population of BMP4-expressing dermal fibroblasts in nascent touch domes.  Concurrently, two populations of sensory neurons preferentially targeted touch domes compared with other skin regions.  Surprisingly, only one neuronal population persisted in mature touch domes.  Overexpression of Noggin, a BMP antagonist, in epidermis at embryonic age 14.5 resulted in fewer touch domes, a loss of Merkel cells, and decreased innervation density in skin areas where touch domes are typically found.  Thus, touch domes bear hallmarks of placode-derived sensory epithelia that require BMP signaling for proper specification.
Near-Field UHF RFID Transponder with a Screen-Printed Graphene Antenna
Creators: name: Jaakkola, Kaarle
name: Sandberg, Henrik
name: Lahti, Markku
name: Ermolov, Vladimir
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: As a method of producing RFID tags, printed graphene provides a low-cost and eco-friendly alternative to the etching of aluminum or copper. The high resistivity of graphene, however, sets a challenge for the antenna design. In practice, it has led to using very large antennas in the UHF RFID far field tags demonstrated before. Using inductive near field as the coupling method between the reader and the tag is an alternative to the radiating far field also at UHF. The read range of such a near field tag is very short, but, on the other hand, the tag is extremely simple and small. In this paper, near field UHF RFID transponders with screen-printed graphene antennas are presented and the effect of the dimensions of the tag and the attachment method of the microchip studied. The attachment of the microchip is an important step of the fabrication process of a tag that has its impact on the final cost of a tag. Of the tags demonstrated, even the smallest one with the outer dimensions of 21 mm * 18 mm and the chip attached with isotropic conductive adhesive (ICA) was readable from a distance of 10 mm with an RF power marginal of 19 dB, which demonstrates that an operational and small graphene-based UHF RFID tag can be fabricated with low-cost industrial processes.
description: 8 pages, 9 figures. IEEE Transactions on Components, Packaging and Manufacturing Technology, 2019
A Method for Pondering Plans in Autonomous Intelligent Systems
Creators: name: Lopez, David
name: Merlino, H.
name: Ierache, Jorge
name: García Martínez, Ramón
Publisher: name: figshare
Year: 2021
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Computer Software
subject: FOS: Computer and information sciences

description: Autonomous intelligent systems (AIS) learn from their environment by forming theories (operators) about how the environment reacts to system’s actions. Each AIS uses the theories it has acquired for building plans (operators sequences) that allow it to reach its self-proposed objectives. In order to improve the performance of the AIS in the process of reaching their objectives, it is necessary to have a method that allows estimating the reliability of the generated plans before their execution. Such a process is called ponderation of plans, and has been successfully applied in previous works. In this paper, a new algorithm for pondering plans is proposed with the goal of improving the performance (percentage of successful plans) and this way, solving problems more efficiently. The experimental results presented clearly show how the proposed method outperforms the classic one.
Covariant Sectors with Infinite Dimension and Positivity of the Energy
Creators: name: Bertozzini, Paolo
name: Conti, Roberto
name: Longo, Roberto
Publisher: name: arXiv
Year: 1997
Subjects: subject: Functional Analysis (math.FA)
subject: High Energy Physics - Theory (hep-th)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider a Moebius covariant sector, possibly with infinite dimension, of a local conformal net of von Neumann algebras on the circle. If the sector has finite index, it has automatically positive energy. In the infinite index case, we show the spectrum of the energy always to contain the positive real line, but, as seen by an example, it may contain negative values. We then consider nets with Haag duality on the real line, or equivalently sectors with non-solitonic extension to the dual net; we give a criterion for irreducible sectors to have positive energy, namely this is the case iff there exists an unbounded Moebius covariant left inverse. As a consequence the class of sectors with positive energy is stable under composition, conjugation and direct integral decomposition.
description: 25 pages, Latex2e
title: Structural Alignments for Similarity Detection in Bioinformatics
Creators: name: Brown, Peter G
Publisher: name: Griffith University
Year: 2019
Subjects: subject: bioinformatics
subject: similarity detection applications
subject: structural alignment of biomolecular proteins
subject: document similarity detection problem

description: This thesis addresses problems involving structural alignments for similarity detection between entities. In the general computational context, a structural alignment is defined as an optimization problem where representative inputs are assigned to relative positions subject to the minimization of some objective function. The output is an inferred relationship based upon the resultant value of the objective function, and/or the arrangement of aligned positions. Two bioinformatics similarity detection applications were used as case studies within this work, the structural alignment of biomolecular proteins and the document similarity detection problem in biomedical literature. The structural alignment of protein biomolecules involves generating residue pair correspondences of maximal overlap with minimal geometric divergence using each protein’s set of three-dimensional atomic coordinates. As protein structure decides its functionality, similarity in structure usually implies similarity in function. During the investigation of this structural alignment problem, it became apparent that a fast and approximate asymmetric linear sum assignment algorithm was required. Accordingly, a new heuristic algorithm, Asymmetric Greedy Search (AGS), was developed. Extensive computational experiments using a range of model graphs demonstrated the effectiveness of the algorithm. In addition, a new type of deterministic model graph that is suitable for reproducible benchmarking of these types of algorithms was also developed. Incorporating AGS, a new non-sequential protein structure alignment method, SPalignNS, was then developed. As compared to existing methods, SPalignNS achieved greater alignment accuracy with commonly used protein alignment test datasets, and also achieved the highest agreement with manually curated reference alignments. The document similarity detection problem is a fundamental application of natural language processing, and constitutes the basis of information retrieval systems. Document matching systems for locating relevant literature have mostly relied on methods developed over a decade ago, largely due to the unavailability of a common evaluation framework. A database of relevance annotations for over 180,000 PubMed-listed document pairs was developed with a subsequent application in training a sentence-based transferred learning model, HuBERT (Hierarchical PubMed BERT). When applied to relevant biomedical literature searches in PubMed, the new HuBERT method produced superior results compared to those attained by the baseline methods from existing document matching systems.
Additional file 1 of LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway
Creators: name: Fu, Dazhi
name: Ren, Yongjun
name: Wang, Chunxiao
name: Yu, Lei
name: Yu, Rui
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Table 1. Differentially regulated lncRNAs between colon cancer tissues (CC) vs paired normal samples.
Scalable repeater architectures for multi-party states
Creators: name: Kuzmin, V. V.
name: Vasilyev, D. V.
name: Sangouard, N.
name: Dür, W.
name: Muschik, C. A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The vision to develop quantum networks entails multi-user applications, which require the generation of long-distance multi-party entangled states. The current rapid experimental progress in building prototype-networks calls for new design concepts to guide future developments. Here we describe an experimentally feasible scheme implementing a two-dimensional repeater network for robust distribution of three-party entangled states of GHZ type in the presence of excitation losses and detector dark counts --- the main sources of errors in real-world hardware. Our approach is based on atomic or solid state ensembles and employs built-in error filtering mechanisms peculiar to intrinsically two-dimensional networks. This allows us to overcome the performance limitation of conventional one-dimensional ensemble-based networks distributing multi-party entangled states and provides an efficient design for future experiments with a clear perspective in terms of scalability.
A Method for Pondering Plans in Autonomous Intelligent Systems
Creators: name: Lopez, David
Publisher: name: figshare
Year: 2021
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Computer Software
subject: FOS: Computer and information sciences

description: Autonomous intelligent systems (AIS) learn from their environment by forming theories (operators) about how the environment reacts to system’s actions. Each AIS uses the theories it has acquired for building plans (operators sequences) that allow it to reach its self-proposed objectives. In order to improve the performance of the AIS in the process of reaching their objectives, it is necessary to have a method that allows estimating the reliability of the generated plans before their execution. Such a process is called ponderation of plans, and has been successfully applied in previous works. In this paper, a new algorithm for pondering plans is proposed with the goal of improving the performance (percentage of successful plans) and this way, solving problems more efficiently. The experimental results presented clearly show how the proposed method outperforms the classic one.
Measurement of Exclusive B Decays to Final States Containing a Charmed Baryon
Creators: name: Dytman, S. A
name: Collaboration, CLEO
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Using data collected by the CLEO detector in the Upsilon(4S) region, we report new measurements of the exclusive decays of B mesons into final states of the type Lambda_c^+ p-bar n(pi), where n=0,1,2,3. We find signals in modes with one, two and three pions and an upper limit for the two body decay Lambda_c^+ pbar. We also make the first measurements of exclusive decays of B mesons to Sigma_c p-bar n(pi), where n=0,1,2. We find signals in modes with one and two pions and an upper limit for the two body decay Sigma_c p-bar. Measurements of these modes shed light on the mechanisms involved in B decays to baryons.
description: 11 pages postscript, also available through http://w4.lns.cornell.edu/public/CLNS, submitted to PRL
Chaetodon ficheuri Arambourg 1927
Creators: name: Carnevale, Giorgio
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Chaetodontidae
Chaetodon
Chaetodon ficheuri

description: ANATOMY OF CHAETODON FICHEURI ARAMBOURG, 1927   EXTERNAL MORPHOLOGY
 Measurements for C. ficheuri are summarized in Table 1. The body is deep, ovoid and laterally compressed (Figs 2, 3). The snout is moderately developed. The specimens examined have a rather variable snout length, mainly related to taphonomic displacement (protrusion or intrusion) of the jaws. The orbit is large. The dorsal fin is continuous with spines that increase gradually in height posteriorly. The soft rays of the centre of the dorsal and anal fins are longer than the others, producing a vertically orientated posterior portion of such fins. Of the three anal fin spines, the middle is best developed, slightly longer and stronger than the third. The pectoral fin inserts low on the body. The pelvic fin originates below and slightly posterior to the pectoral fin. The caudal fin is truncate and extends well beyond the posterior edges of the dorsal and anal fins.
description: Published as part of Carnevale, Giorgio, 2006, Morphology and biology of the Miocene butterflyfish Chaetodon ficheuri (Teleostei: Chaetodontidae), pp. 251-267 in Zoological Journal of the Linnean Society 146 (2) on page 254, DOI: 10.1111/j.1096-3642.2006.00203.x, http://zenodo.org/record/5435739
Cellular dg-categories and their applications to homotopy theory of A-infinity categories
Creators: Kravets, Oleksandr
Publisher: name: Columbia University
Year: 2020
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Algebra, Homological
subject: Topology
subject: Algebra, Abstract
subject: Topological spaces

description: We introduce the notion of cellular dg-categories mimicking the properties of topological CW-complexes. We study the properties of such categories and provide various examples corresponding to the well-known geometrical objects. We also show that these categories are suitable for encoding coherence conditions in homotopy theoretical constructs involving A-infinity categories. In particular, we formulate the notion of a homotopy coherent monoid action on an A-infinity category which can be used in constructions involved in Homological Mirror Symmetry.
On the structure of systematic perturbation theory with unstable fields
Creators: name: Tkachov, Fyodor V.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Discussed is the structure of non-trivial counterterms that occur in the systematic gauge-invariant perturbation theory with unstable fields introduced in [hep-ph/9802307].
description: 4pp PS; talk at QFTHEP'99, 27 May - 2 June 1999, Moscow
Cellular features predicting susceptibility to ferroptosis: insights from cancer cell-line profiling
Creators: Viswanathan, Vasanthi
Publisher: name: Columbia University
Year: 2015
Subjects: Cancer
Enzyme inhibitors
Cell death
Cytology

description: Ferroptosis is a novel non-apoptotic, oxidative form of regulated cell death that can be triggered by diverse small-molecule ferroptosis inducers (FINs) and genetic perturbations. Current lack of insights into the cellular contexts governing sensitivity to ferroptosis has hindered both translation of FINs as anti-cancer agents for specific indications and the discovery of physiological contexts where ferroptosis may function as a form of programmed cell death. This dissertation describes the identification of cellular features predicting susceptibility to ferroptosis from data generated through a large-scale profiling experiment that screened four FINs against a panel of 860 omically-characterized cancer cell lines (Cancer Therapeutics Response Portal Version 2; CTRPv2 at http://www.broadinstitute.org/ctrp/).
      Using correlative approaches incorporating transcriptomic, metabolomic, proteomic, and gene-dependency feature types, I uncover both pan-lineage and lineage-specific features mediating cell-line response to FINs. The first key finding from these analyses implicates high expression of sulfur and selenium metabolic pathways in conferring resistance to FINs across lineages. In contrast, the transsulfuration pathway, which enables de novo cysteine synthesis, appears to plays a role in ferroptosis resistance in a subset of lineages. The second key finding from these studies identifies cancer cells in a high mesenchymal state as being uniquely primed to undergo ferroptosis. This susceptibility stems from a specific dependency of high mesenchymal-state cancer cells on the lipid hydroperoxide quenching mechanisms inhibited by FINs and is conserved across cancer cell lines of mesenchymal origin, epithelial-derived cancer cell lines that have undergone an epithelial-to-mesenchymal-transition, and patient-derived cancer cells exhibiting mesenchymal state-mediated resistance to anti-cancer therapies.
      The work presented herein formalizes frameworks for studying small molecule inducers of cell death through cell-line profiling. The results advance current mechanistic understanding of the cellular circuitry underlying ferroptosis sensitivity and lay the foundation for a novel therapeutic approach using ferroptosis inducers to target high mesenchymal-state cancer cells.
A kernel nonparametric quantile estimator for right-censored competing risks data
Creators: name: Caiyun Fan
name: Ding, Gang
name: Feipeng Zhang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: In medical and epidemiological studies, it is often interest to study time-to-event distributions under competing risks that involve two or more failure types. Nonparametric analysis of competing risks is typically focused on the cumulative incidence function or nonparametric quantile function. However, the existing estimators may be very unstable due to their unsmoothness. In this paper, we propose a kernel nonparametric quantile estimator for right-censored competing risks data, which is a smoothed version of Peng and Fine's nonparametric quantile estimator. We establish the Bahadur representation of the proposed estimator. The convergence rate of the remainder term for the proposed estimator is substantially faster than Peng and Fine's quantile estimator. The pointwise confidence intervals and simultaneous confidence bands of the quantile functions are also derived. Simulation studies illustrate the good performance of the proposed estimator. The methodology is demonstrated with two applications of the Supreme Court Judge data and AIDSSI data.
title: Follow your neighbor?
title: Regional emulation and the design of transparency policies
titleType: Subtitle
Creators: name: Berliner, Daniel
Publisher: name: Freie Universität Berlin
Year: 2013
Subjects: subject: 300 Sozialwissenschaften::320 Politikwissenschaft

description: 1\. Introduction 5 2\. The Global Spread of the Freedom of Information 7 3\. The Diffusion of Policy Design 9 3.1 Uncertainty and Emulation 9 3.2 Illustrative Evidence 10 4\. A Quantitative Approach to Policy Design and Policy Similarity 14 4.1 Measuring the Design of FOI Laws 14 4.2 Modeling Policy Similarity among Country-Pairs 15 5\. Model Results 17 5.1 Regional Emulation 17 5.2 Alternative Diffusion Mechanisms 18 6\. Conclusion 23 Bibliography 25
description: How do countries make policy in an uncertain world? Do policymakers look inward, rationally designing policies to fit domestic interests, ideas, and institutions? Or do they look outward, imitating policy elements from other countries? And if the latter, where do they look? Focusing on the specific policy area of Freedom of Information laws, I argue that regional emulation plays an important role in shaping policy design. Policymakers face substantial uncertainty over the consequences of different design choices, and so emulate other countries as policy models. I further argue that, due to availability bias, countries in the same region serve as the most important such models. After reviewing numerous examples of such emulation, I model the policy similarity between 4,096 pairs of countries, and find that countries in the same region, or more geographically proximate, tend to have more similar laws than other country-pairs. These results are robust to different categorizations of region, fixed effects capturing country-specific features, and testing against alternative forms of emulation as well as alternative diffusion mechanisms of competition, coercion, conditionality, and learning. This approach also highlights the diffusion of policy design, as opposed to adoption, as an important future direction for policy diffusion research.