cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array
Creators: name: Price, Magda E.
name: Cotton, Allison M.
name: Lam, Lucia L.
name: Farré, Pau
name: Emberly, Eldon
name: Brown, Carolyn Janet
name: Robinson, Wendy P.
name: Kobor, Michael S. (Geneticist)
Publisher: name: BioMed Central
Year: 2015

description: Background. Measurement of genome-wide DNA methylation (DNAm) has become an important avenue for investigating potential physiologically-relevant epigenetic changes. Illumina Infinium (Illumina, San Diego, CA, USA) is a commercially available microarray suite used to measure DNAm at many sites throughout the genome. However, it has been suggested that a subset of array probes may give misleading results due to issues related to probe design. To facilitate biologically significant data interpretation, we set out to enhance probe annotation of the newest Infinium array, the HumanMethylation450 BeadChip (450 k), with >485,000 probes covering 99% of Reference Sequence (RefSeq) genes (National Center for Biotechnology Information (NCBI), Bethesda, MD, USA). Annotation that was added or expanded on includes: 1) documented SNPs in the probe target, 2) probe binding specificity, 3) CpG classification of target sites and 4) gene feature classification of target sites. Results Probes with documented SNPs at the target CpG (4.3% of probes) were associated with increased within-tissue variation in DNAm. An example of a probe with a SNP at the target CpG demonstrated how sample genotype can confound the measurement of DNAm. Additionally, 8.6% of probes mapped to multiple locations in silico. Measurements from these non-specific probes likely represent a combination of DNAm from multiple genomic sites. The expanded biological annotation demonstrated that based on DNAm, grouping probes by an alternative high-density and intermediate-density CpG island classification provided a distinctive pattern of DNAm. Finally, variable enrichment for differentially methylated probes was noted across CpG classes and gene feature groups, dependant on the tissues that were compared. Conclusion DNAm arrays offer a high-throughput approach for which careful consideration of probe content should be utilized to better understand the biological processes affected. Probes containing SNPs and non-specific probes may affect the assessment of DNAm using the 450 k array. Additionally, probe classification by CpG enrichment classes and to a lesser extent gene feature groups resulted in distinct patterns of DNAm. Thus, we recommend that compromised probes be removed from analyses and that the genomic context of DNAm is considered in studies deciphering the biological meaning of Illumina 450 k array data.
title: EL DJEM
title: EL DJEM
title: Atlas archéologique de la Tunisie
Creators: name: Babelon, Ernest Charles François
name: Babelon, Ernest Charles François > Auteur
name: Cagnat, René Louis Victor > Auteur
name: Reinach, Salomon > Auteur
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Archéologie
subject: Antiquité
subject: Recherche archéologique
subject: Savoirs (Les)
subject: Cartographie
subject: Atlas
subject: Atlas archéologique

description: [Atlas archéologique de la Tunisie ; Edition spéciale des cartes topographiques publiées par la ministère de la Guerre, accompagnée d’un texte explicatif rédigé par E. Babelon, R. Cagnat et S. Reinach, membres de la Commission de l’Afrique du Nord (1ère série, 60 feuilles au 1/50 000 et notices)]
description: Atlas
description: Atlas-Archeo-Tunisie_056
description: 1/50 000
description: La Méditerranée à la carte
description: Paris
description: Source: Institut de recherche sur le Maghreb contemporain (IRMC); Cité numérique de la Méditerranée (MMSH)
description: Source: La Méditerranée à la carte
description: Source: La Méditerranée à la carte > Atlas archéologique de la Tunisie
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/96218
description: Coverage: Tunisie
description: Coverage: El Djem
description: Coverage: Antiquité
description: Temporal: Antiquité
description: Provenance: Institut de recherche sur le Maghreb contemporain (IRMC); Cité numérique de la Méditerranée (MMSH)
Additional file 1 of EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
Creators: name: Dutta, Debasmita
name: Al Hoque, Ashique
name: Paul, Brahamacharry
name: Park, Jun Hyoung
name: Chowdhury, Chinmay
name: Quadir, Mohiuddin
name: Banerjee, Soumyabrata
name: Choudhury, Arghadip
name: Laha, Soumik
name: Sepay, Nayim
name: Boro, Priyanka
name: Kaipparettu, Benny Abraham
name: Mukherjee, Biswajit
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Materail 1.
Jean-Paul Vernant
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 fichier (2 pages). Autres destinataires : Dominique Mathez, Caroline Petit, Hervé Latapie, Richard Cross.
Looking for Kikan-Shido: are elements of it detectable in tertiary engineering pedagogy?
Creators: name: Banky, George
Publisher: name: Swinburne
Year: 2024

description: Comparative studies of year eight mathematics and science classes in schools around the world have identified Kikan-Shido as a regularly practiced pedagogy. This paper contends that Kikan-Shido in these instances does not result from any identifiable and unique secondary school teaching philosophy and it is likely to be present for the successful delivery of problem-based teaching activities, particularly in mathematics and/or sciences based syllabi. In order to test this hypothesis for engineering education, four active computer-based revision tutorials in a subject that formed part of some undergraduate engineering courses at a tertiary institution were audio recorded and then storyboarded for later analysis. The possible occurrences of Kikan-Shido activities in such a common tertiary learning environment were investigated by analysing the teacher-student verbal communication and then comparing the identified practiced pedagogy with some of those defined for the earlier mentioned global study in secondary schools. A recommendation is made to extend any follow-up studies to include the tabulation of Kikan-Shido 'activity patterns' which may be investigated for their suitability as a catalyst for the development of a metric for teaching quality.
ผลกระทบจากอุทกภัยที่มีต่อพนักงานบริการหญิงและบริการด้านการป้องกันโรคเอดส์และโรคติดต่อทางเพศสัมพันธ์
Creators: name: ชีวนันท์ เลิศพิริยสุวัฒน์
Publisher: name: กองแผนงาน
Year: 2555
Subjects: ผลกระทบจากอุทกภัย พนักงานบริการหญิง การป้องกันโรคเอดส์และโรคติดต่อทางเพศสัมพันธ์

description: วารสารควบคุมโรค, 38, 2, 109-120
‘On the same level’: facilitators’ experiences running a drug user-led safer injecting education campaign
Creators: name: Callon, Cody
name: Charles, Grant
name: Alexander, Rick
name: Small, Will
name: Kerr, Thomas
Publisher: name: BioMed Central
Year: 2016

description: Background: Unsafe injection practices play a major role in elevated rates of morbidity and mortality among people who inject drugs (IDU). There is growing interest in the direct involvement of IDU in interventions that seek to address unsafe injecting. This study describes a drug user-led safer injecting education campaign, and explores facilitators’ experiences delivering educational workshops. Methods: We conducted semi-structured qualitative interviews with 8 members of the Injection Support (IS) Team who developed and facilitated a series of safer injecting education workshops. Interviews explored facilitator’s perceptions of the workshops, experiences being a facilitator, and perspectives on the educational campaign. Interviews were transcribed verbatim and a thematic analysis was conducted. Results: IS Team facilitators described how the workshop’s structure and content enabled effective communication of information about safer injecting practices, while targeting the unsafe practices of workshop participants. Facilitators’ identity as IDU enhanced their ability to relate to workshop participants and communicate educational messages in language accessible to workshop participants. Facilitators reported gaining knowledge and skills from their involvement in the campaign, as well as positive feelings about themselves from the realization that they were helping people to protect their health. Overall, facilitators felt that this campaign provided IDU with valuable information, although facilitators also critiqued the campaign and suggested improvements for future efforts. Conclusions: This study demonstrates the feasibility of involving IDU in educational initiatives targeting unsafe injecting. Findings illustrate how IDU involvement in prevention activities improves relevance and cultural appropriateness of interventions while providing individual, social, and professional benefits to those IDU delivering education.
title: Cultivating Competence
title: Chinese Medicine Student Clubs in Taipei, Taiwan
titleType: Subtitle
Creators: name: Buchner, Karoline
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Chinese medicine
subject: Taiwan
subject: professionalization
subject: lay knowledge
subject: traditional medicine
subject: medical anthropology
subject: biomedical hegemony
subject: science and technology studies
subject: 300 Sozialwissenschaften::300 Sozialwissenschaften, Soziologie::301 Soziologie, Anthropologie

description: This thesis focuses on a communal form of transmission of Chinese medicine in contemporary Taiwan: Chinese medicine university student clubs. Offering fundamental Chinese medicine curricula to students and the interested public, the student clubs used to serve as a direct educational steppingstone towards licensed practice. Recent changes in medical education policy, however, made a university degree in Chinese medicine a requirement, thereby pushing informal ways of knowledge transmission into the realm of lay activity. Nevertheless, the clubs remain active and still serve as a community for people interested in Chinese medicine, including those wanting to pursue it professionally. Based on field research conducted in two such university clubs in Taipei in early 2018, this thesis first outlines the challenges and tensions faced and negotiated by those club members with professional ambitions. Not (yet) enrolled in “official” Chinese medicine programs at university but already deeply engaged in learning, they constitute a group of people rarely represented in academic literature, namely those just orienting themselves towards becoming Chinese medicine physicians. These processes of orientation and becoming are shaped by organizational, economic, and epistemological pressures and embedded in transnational movements, imaginaries, and regulatory regimes. Secondly, the thesis examines the function and position of the clubs in the changing landscape of Chinese medical education in Taiwan, as well as in the wider field of transmission of Chinese medicine. I argue that they foster continued interest in Chinese medicine in an environment that has favored biomedicine since the Japanese colonial era and that they, although through paths more winded than before, still contribute to the reproduction of professional Chinese medical expertise. In addition, they provide space for communal forms of healthcare. Lastly, they contribute to the maintenance of everyday healthcare competence in the wider public, or what Arthur Kleinman (1980) has called the “popular sector of healthcare.”
Evidence for electron transfer between graphene and non‐covalently bound π‐systems
Creators: name: Brülls, Steffen M.
name: Cantatore, Valentina
name: Wang, Zhenping
name: Tam, Pui Lam
name: Malmberg, Per
name: Stubbe, Jessica
name: Sarkar, Biprajit
name: Panas, Itai
name: Mårtensson, Jerker
name: Eigler, Siegfried
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: doping
subject: functionalization
subject: graphene
subject: sensors
subject: trication
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::547 Organische Chemie

description: Hybridizing graphene and molecules possess a high potential for developing materials for new applications. However, new methods to characterize such hybrids must be developed. Herein, the wet‐chemical non‐covalent functionalization of graphene with cationic π‐systems is presented and the interaction between graphene and the molecules is characterized in detail. A series of tricationic benzimidazolium salts with various steric demand and counterions was synthesized, characterized and used for the fabrication of graphene hybrids. Subsequently, the doping effects were studied. The molecules are adsorbed onto graphene and studied by Raman spectroscopy, XPS as well as ToF‐SIMS. The charged π‐systems show a p‐doping effect on the underlying graphene. Consequently, the tricationic molecules are reduced through a partial electron transfer process from graphene, a process which is accompanied by the loss of counterions. DFT calculations support this hypothesis and the strong p‐doping could be confirmed in fabricated monolayer graphene/hybrid FET devices. The results are the basis to develop sensor applications, which are based on analyte/molecule interactions and effects on doping.
China nach der Jahrtausendwende: Asiatische Großmacht zwischen Einbindung und hegemonialen Ambitionen
Creators: name: Jetschke, Anja
Publisher: name: Internationales Asienforum
Year: 2016

description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
SUSANNE WEIGELIN-SCHWIEDRZIK, DAGMAR HAUF (eds.): Ländliche Unternehmen in der Volksrepublik China
Creators: name: Heuser, Robert
Publisher: name: Internationales Asienforum
Year: 2016

description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Essential service markets: historical lessons
Creators: name: Sharam, Andrea
Publisher: name: Swinburne
Year: 2024

description: The introduction of competition into essential services such as utilities, telecommunications, banking, medical care, education and transport continues to generate heated debate. Market principles have extended deeply into sectors of the economy that would have been regarded as unthinkable not so long ago. Yet surprisingly little attention has been paid to the historical market and policy failures apparent in what could be described as traditional essential service markets.
Sexual orientation and self-reported mood disorder diagnosis among Canadian adults
Creators: name: Pakula, Basia
name: Shoveller, Jean
Publisher: name: BioMed Central
Year: 2016

description: Background: The prevalence and correlates of mood disorders among people who self-identify as lesbian, gay or bisexual (LGB) are not well understood. Therefore, the current analysis was undertaken to estimate the prevalence and correlates of self-reported mood disorders among a nationally representative sample of Canadian adults (ages 18 to 59 years). Stratified analyses by age and sex were also performed. Methods: Using data from the 2007–2008 Canadian Community Health Survey, logistic regression techniques were used to determine whether sexual orientation was associated with self-reported mood disorders. Results: Among respondents who identified as LGB, 17.1% self-reported having a current mood disorder while 6.9% of heterosexuals reported having a current mood disorder. After adjusting for potential confounders, LGB-respondents remained more likely to report mood disorder as compared to heterosexual respondents (AOR: 2.93; 95% CI: 2.55-3.37). Gay and bisexual males were at elevated odds of reporting mood disorders (3.48; 95% CI: 2.81–4.31), compared to heterosexual males. Young LGB respondents (ages 18–29) had higher odds (3.75; 95% CI: 2.96–4.74), compared to same-age heterosexuals. Conclusions: These results demonstrate elevated prevalence of mood disorders among LGB survey respondents compared to heterosexual respondents. Interventions and programming are needed to promote the mental health and well being of people who identify as LGB, especially those who belong to particular subgroups (e.g., men who are gay or bisexual; young people who are LGB).
INM317 Design Justice Course Work, 2025: Move Fast, Break Hearts. Emotional AI Companions: The Hidden Costs of Careless Innovation
Creators: name: Ahmed, Omar
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 460208
subject: Natural language processing
classificationCode: 460806
subject: Human-computer interaction

description: This zine critically explores the emotional harms of AI companion platforms through the lens of Design Justice. Focusing on the 2024 cases of Sewell Setzer and J.F., it examines how platforms like Character.AI use emotionally immersive design to simulate care while avoiding accountability. Drawing on public reports, academic sources, and fictionalised chat excerpts, the zine highlights how persuasive interfaces, sycophantic AI, and neoliberal values intersect to produce systems that exploit vulnerability. It calls for a justice-oriented redesign that centres safety, consent, and emotional responsibility in emerging technologies.
BERNHARD DAHM, RODERICH PTAK (eds.): Südostasien-Handbuch. Geschichte, Gesellschaft, Politik, Wirtschaft, Kultur
Creators: name: Jetschke, Anja
Publisher: name: Internationales Asienforum
Year: 2016

description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon
Creators: name: Dirks, Rachel C
name: Richard, Jeffrey S
name: Fearon, Angela M
name: Scott, Alexander
name: Koch, Lauren G
name: Britton, Steven L
name: Warden, Stuart J
Publisher: name: BioMed Central
Year: 2016

description: Background: The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Methods: Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis. Results: There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14). Conclusions: Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
Avacincaptad pegol in geographic atrophy secondary to age-related macular degeneration: a profile of its use
Creators: name: Zhuang-Yan, Amy
name: Blair, Hannah A.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine
Ophthalmology

description: Declarations

Funding The preparation of this review was not supported by any external funding.

Authorship and conflict of interest A. Zhuang-Yan and H. A. Blair are salaried employees of Adis International Ltd/Springer Nature and declare no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.

Ethics approval, Consent to participate, Consent for publication, Availability of data and material, Code availability Not applicable.

Additional information about this Adis Drug Review can be found here. 
  
Avacincaptad pegol (IZERVAYTM), a complement C5 inhibitor, is a promising new treatment option for patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). In phase 2/3 (GATHER1) and phase 3 (GATHER2) trials in adults with non-center point involving GA secondary to AMD, monthly intravitreal injection of avacincaptad pegol demonstrated a significant reduction in GA lesion growth rate over a period of 12 months. There were no significant differences in the mean change in best-corrected visual acuity (BCVA) and low-luminance BCVA between the avacincaptad pegol and sham groups. Avacincaptad pegol was generally well tolerated, with the most common adverse reactions being conjunctival hemorrhage, increased intraocular pressure, blurred vision, and choroidal neovascularization. Preliminary data from the 24-month analyses of GATHER2 have shown continued efficacy up to 24 months.
  

© Springer Nature Switzerland AG 2024
A case study of HyFlex in GIS classes at the University of Illinois
Creators: name: Minn, Michael
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: This paper is a case study of two undergraduate geographic information systems (GIS) classes offered in hybrid flexible (HyFlex) mode at the University of Illinois (USA) in the Spring semester of 2022. A specific focus is placed on the relationship between student performance and the percentage of course time spent in in-person vs. online synchronous mode during semiweekly interactive sessions. Multiple regression analysis was performed using final semester course scores as the dependent variable and percentage of online interactive session participation, absenteeism, overall grade point average, and expressed gender as independent variables. The analysis results were consistent with existing research in finding no significant relationship between levels of online interactive session participation and final semester course scores. Although the results in this case study cannot and should not be generalized, the broader objective of this report is to share specific performance results that can inform future research on the effectiveness of HyFlex instruction in GIS.
Developing methodologies and software for Bayesian inference of transmission trees from epidemiological and genetic data
Creators: name: Campbell, Finlay
Publisher: name: Imperial College London
Year: 2019

description: Outbreaks of infectious disease pose an enormous global burden on human well-being. Effectively controlling such outbreaks requires timely and evidence-based interventions, which are increasingly being informed by statistical modelling efforts. A specific field of statistical modelling attempts to reconstruct the history of transmission events between individual cases in order to provide high-resolution epidemiological insights directly relevant to infection control. Recent years have seen considerable methodological progress in this regard, with an emphasis on using whole genome sequencing (WGS) data. However, current methods largely disregard other types of outbreak data and are therefore poorly suited to outbreaks where WGS data is unavailable or weakly informative. This thesis aims to improve the utility and widen the scope of outbreak reconstruction tools by incorporating additional types of outbreak data. I begin with an overview of this field of research (Chapter 1). I then conduct a simulation study to evaluate the realistic informativeness of WGS data for different pathogens (Chapter 2). Next, I develop methods and software for integrating commonly available epidemiological data, namely contact data (Chapter 3) and hospital ward data (Chapter 4), into the inference of transmission chains. Finally, I consider outbreak reconstruction in a more operational context. I develop a simple algorithm and software tool for visualising timed transmission networks (Chapter 5) and then apply the methods developed in this thesis to synthesized data resembling the ongoing Ebola outbreak in the Democratic Republic of Congo (Chapter 6). In the last chapter, I discuss the methodological components of this thesis and end on a more general reflection of how outbreak reconstruction tools can be realistically used in outbreak settings to reduce the burden of disease.
WERNER M. EGLI: Bier für die Ahnen. Erbrecht, Tausch und Ritual bei den Sunuwar Ostnepals
Creators: name: Seeland, Klaus
Publisher: name: Internationales Asienforum
Year: 2016

description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Invisible walls: madness, distress and the boundaries of credibility
Creators: name: Carter, Meg
Publisher: name: Swinburne
Year: 2024

description: This paper describes a conceptual model for thinking about different understandings of mental health and illness. I use this model to identify tensions that exist in mental health policy and practice in Australia, and some of the consequences that flow from these. I argue that in Australia, disciplinary and service cultures are grounded in differing and unarticulated assumptions about the meaning of service users‘ experience. These differences create barriers to communication between practitioners working in different service types. They also make it difficult for service users, carers and newcomers to the sector to make sense of what they hear. Unarticulated assumptions construct invisible walls, marking the boundaries that separate views that can be regarded as credible in conversations about mental health, from those that cannot.
title: Factors facilitating and inhibiting gender diversity at the organisational and societal levels: Emotionality in diversity statements and traditional masculinities
Creators: name: Krivoshchekov, Vladislav
Publisher: name: Universität Bern
Year: 2024
Subjects: subject: 150 Psychology
subject: 300 Social sciences, sociology & anthropology

description: Extensive efforts have been undertaken to address discrimination and promote diversity within both societal and organisational contexts. This dissertation comprises two distinct manuscripts, each offering insight into factors that can either facilitate or inhibit diversity efforts at the organisational and societal levels. The first manuscript reports research on language cues in organisational diversity statements. It explores how subtle language cues can contribute to more effective organisational communication in attracting diverse talents. The results illuminated the practices of European organisations, revealing a notable absence of highly emotional language in their diversity statements. Additionally, existing high levels of emotionality in the diversity statements were no more effective in shaping more positive attitudes toward the organisation than low levels of emotionality in the diversity statements. Finally, experimental evidence suggested that organisations seeking to increase people’s favourable attitudes toward them should use high levels of emotionality in their diversity statements, as weak emotionality is no more effective than no emotionality in shaping positive attitudes toward the organisation, independent of past experiences of exclusion. The second manuscript reports a meta-analysis of the relationship between traditional masculinities and men’s violence against women. The findings indicated that men who adhere to rigid traditional masculine norms tend to report more violent attitudes and behaviours against women. However, we observed considerable heterogeneity in effect sizes derived from original studies. To investigate the factors that might explain this heterogeneity, a moderation analysis was carried out, with the type of traditional masculinities (i.e., traditional masculinity ideology, conformity to masculine norms, experience of gender role stress), type of violence (i.e., sexual harassment, rape, physical, and psychological), and context of violence (i.e., intimate and non-intimate) being used as moderators. The moderation analysis evinced the strongest correlations between traditional masculinity ideology and attitudes toward violence, and between traditional masculinities and sexual harassment. Interestingly, types of traditional masculinities and violence did not affect the relationship between traditional masculinities and violent behaviour. Additionally, we observed that domains of traditional masculinities differed in their associations with men’s violence against women. The research presented in this dissertation holds valuable insights that can be leveraged to achieve gender diversity in organisations and society at large.
The best of times, the worst of times
Creators: name: Browne, Peter
Publisher: name: Swinburne
Year: 2024

description: Behind the Princess Marina Hospital, not far from the centre of Gaborone, are the two small buildings that house Botswana’s largest anti-retroviral therapy clinic for people with HIV/AIDS. Alongside the red-brick blocks of the main hospital complex, these prefabricated buildings seem modest an temporary, nut it was here that Botswana’s ambitious HIV/AIDS treatment program – the first national scheme in Africa – was launched in early 2002. Over the past five years, the number of clinics across this sparsely populated country has grown exponentially, and there are now thirty-two sites, each with up to four satellite clinics, serving a national population of 1.8 million.
Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation
Creators: name: Pan, Guoqing
name: Xu, Jinshan
name: Li, Tian
name: Xia, Qingyou
name: Liu, Shao-Lun
name: Zhang, Guojie
name: Li, Songgang
name: Li, Chunfeng
name: Liu, Handeng
name: Yang, Liu
name: Liu, Tie
name: Zhang, Xi
name: Wu, Zhengli
name: Fan, Wei
name: Dang, Xiaoqun
name: Xiang, Heng
name: Tao, Meilin
name: Li, Yanhong
name: Hu, Junhua
name: Li, Zhi
name: Lin, Lipeng
name: Luo, Jie
name: Geng, Lina
name: Wang, LinLing
name: Long, Mengxian
name: Wan, Yongji
name: He, Ningjia
name: Zhang, Ze
name: Lu, Cheng
name: Keeling, Patrick J. (Patrick John), 1969-
name: Wang, Jun
name: Xiang, Zhonghuai
name: Zhou, Zeyang
Publisher: name: BioMed Central
Year: 2015

description: Background: Microsporidian Nosema bombycis has received much attention because the pébrine disease of domesticated silkworms results in great economic losses in the silkworm industry. So far, no effective treatment could be found for pébrine. Compared to other known Nosema parasites, N. bombycis can unusually parasitize a broad range of hosts. To gain some insights into the underlying genetic mechanism of pathological ability and host range expansion in this parasite, a comparative genomic approach is conducted. The genome of two Nosema parasites, N. bombycis and N. antheraeae (an obligatory parasite to undomesticated silkworms Antheraea pernyi), were sequenced and compared with their distantly related species, N. ceranae (an obligatory parasite to honey bees). Results Our comparative genomics analysis show that the N. bombycis genome has greatly expanded due to the following three molecular mechanisms: 1) the proliferation of host-derived transposable elements, 2) the acquisition of many horizontally transferred genes from bacteria, and 3) the production of abundnant gene duplications. To our knowledge, duplicated genes derived not only from small-scale events (e.g., tandem duplications) but also from large-scale events (e.g., segmental duplications) have never been seen so abundant in any reported microsporidia genomes. Our relative dating analysis further indicated that these duplication events have arisen recently over very short evolutionary time. Furthermore, several duplicated genes involving in the cytotoxic metabolic pathway were found to undergo positive selection, suggestive of the role of duplicated genes on the adaptive evolution of pathogenic ability. Conclusions Genome expansion is rarely considered as the evolutionary outcome acting on those highly reduced and compact parasitic microsporidian genomes. This study, for the first time, demonstrates that the parasitic genomes can expand, instead of shrink, through several common molecular mechanisms such as gene duplication, horizontal gene transfer, and transposable element expansion. We also showed that the duplicated genes can serve as raw materials for evolutionary innovations possibly contributing to the increase of pathologenic ability. Based on our research, we propose that duplicated genes of N. bombycis should be treated as primary targets for treatment designs against pébrine.
title: Walter Ducloux Collection finding aid
Creators: name: Staff, Fine Arts Library
Publisher: name: The University of Texas at Austin
Year: 2024
Subjects: subject: Operas
subject: Live performances
subject: University of Southern California
subject: University of Texas at Austin
subject: Walter Ducloux

description: The collection consists of noncommercial recordings of classical music concerts, predominantly conducted by Walter Ducloux. The largest portion of the collection consists of concerts performed by student ensembles at the University of Southern California and the University of Texas at Austin. Orchestras with a smaller representation of recordings in the collection include the Stanford Symphony Orchestra, the Glendale Symphony, the NBC Symphony Orchestra and the BBC Symphony Orchestra.
description: Fiinding aid for the collection -- About the collection
MEK inhibition reprograms chimeric antigen receptor-T cells into a less exhausted and differentiated state
Creators: name: 王修健(Xiujian Wang)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Transcriptome or Gene expression
Monoisolate

description: Large quantities of studies have demonstrated poor persistence of chimeric antigen receptor-T cells (CAR-T) due to T cell exhaustion and terminal differentiation has restricted the therapeutic efficacy of this immunotherapy. One of promising strategies to enhance the persistence of CAR-T cells is to combine CAR-T cells with targeted small-molecule inhibitors (SMIs). Herein, we demonstrated MEK inhibitors could diminish CAR-T cells’ exhaustion and terminal differentiation and consequently, lead to rejuvenation of CAR-T cells characterized by acquisition of a memory-like phenotype and durable anti-tumor activities both in vitro and in vivo. Global bulk and single-cell transcriptional profiling indicated MEK inhibition conferred more persistence to CAR-T cells via restoring expression of memory-associated genes and reducing expression of activation-, exhaustion-, mitosis-, metabolism-associated and proapoptotic genes. Collectively, our research provides a new method with potential translational value to extend the persistence of CAR-T cells and thus improve the prognosis of patients receiving this emerging immunotherapy.
A problematic approach to the science of sustainable design
Creators: name: Feast, Luke
Publisher: name: Swinburne
Year: 2024

description: In industrialised countries the reduction of the consumption of resources is recognised as the first step toward sustainable development. Achieving this will require an economic change which divorces economic success from resource consumption. An emerging trend in design research that is directly concerned with such 'dematerialisation' is for businesses to realign their corporate strategies toward the selling of performance rather than goods through the design of product-service combinations. In such a 'service' economy products cannot be completely defined by an essential and eternal form because productservices change in ways that are unforeseeable to the designer. This paper considers that such an epistemological shift can be conceptualised, following the philosophy of Gilles Deleuze (1925-1995) as the transition from an axiomatic to a problematic approach to design. This paper will develop and explain the differences and similarities between these two approaches and then draw out the implications for sustainable design and the relation between design and science.
STEPHAN CONERMANN (Hrsg.): Mythen, Geschichte(n), Identitäten: Der Kampf um die Vergangenheit
Creators: name: Richter, Antje
Publisher: name: Internationales Asienforum
Year: 2016

description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
LI-YUN BAUER-HSIEH (Hrsg.): Facies - Facetten. In Memoriam Wolfgang Bauer (1930-1970). Zu seinem 70. Geburtstag.
Creators: name: Kantowsky, Detlef
Publisher: name: Internationales Asienforum
Year: 2016

description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
The Constitutional Abolition of War in Japan. Monument of a Culture of Peace?
Creators: name: Schlichtmann, Klaus
Publisher: name: Internationales Asienforum
Year: 2016

description: Quite unnoticed by the 'rest of the world', Japan has in the past few decades developed a much criticized and often misunderstood 'culture of peace', fostering international conciliation and cooperation. However, following the end of the Cold War and especially the Gulf War, pressure is mounting for Japan to amend its Constitution, give the military institution a f~ basis by establishing a defense ministry, and take up so-called peacekeepmg. Such measures could, however, be counterproductive to achieving general and complete disarmament, non-military guarantees for maintaining peace and 'human security'. Rather than reinforcing military institutions, non-military components conducive of a 'culture of peace' should be strengthened as the Japanese Constitution suggests. Instead of persuading Japan to change its constitution, the international community should consider following up along the lines of the UN Charter, in accordance with their respective constitutional processes.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Genome sequence resources for five strains belonging to the genus Gliocladium
Creators: name: 周康(Kang Zhou)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Raw sequence reads
Genome sequencing
Monoisolate
Agricultural

description: In this study, we sequenced the genomes of five strains (Gliocladium viride, G. catenulatum, G. roseum, G. deliguescens and G. penicilloides) from the genus Gliocladium, which was collected from China General Microbiological Culture Collection Center (CGMCCC) and China Agricultural Culture Collection Center (CACCC).
"Koloniale Industrialisierung" in Korea? Eine Kritik an Ulrich Menzel
Creators: name: Man-Su, Kim
Publisher: name: Internationales Asienforum
Year: 2016

description: The theory of "colonial industrialization" proposed by Ulrich Menzel emphasizes "colonial inheritance" as a crucial factor in the rapid industrial growth of South Korea from the 1960's onwards. According to Menzel, enormous investments by the Japanese in building and extending infrastructure, in energy supply, mining and modernization of the Korean state, administration and educational system etc provided Korea with a better start than other developing countries. As a matter of fact, the investment was part and parcel of Japanese exploitation and expropriation, and did not lead to the independent development of Korea. Also, up to 80 % of infrastructure and industry were destroyed in the Korean War. Likewise, through the division of Korea the complementary character of the North (energy, mining and heavy industry) und the South (rice production and light industry) lost their relevance. Moreover, Menzel did not mention why the colonial inheritance failed to have any impact after Korean independence. Also, the Japanese defeat in World War ll did not coincide with any changes in the Korean political situation. All in all, the theory of colonial industrialization is a theory of colonial power, not of the colony itself.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Die chinesische Minderheit und die japanische Besatzung - Java 1942 - 1945
Creators: name: Kwartanada, Didi
Publisher: name: Internationales Asienforum
Year: 2016

description: This contribution deals with one of the less-known aspects of Indonesian historiography: the Chinese minority under Japanese occupation. Due to the administrative division during wartime Indonesia, the geographical subject is limited to Java island. Three major questions are addressed by the author: (1) the Chinese adaptation process in the new political system (from Dutch to Japanese regime), (2) Japanese policies towards the Chinese minority during the occupation, (3) the impact of Japanese occupation on the Chinese, with special reference to their political stance towards the Indonesian revolution. In conclusion, the author describes the political situation of the Chinese in Indonesia fifty years after the occupation (in Soeharto's New Order), which retains certain patterns similar to the Japanese occupation days.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
National Integration of Indonesia: Aceh's Experience. A concerned view from the region
Creators: name: Thaib, Lukman
Publisher: name: Internationales Asienforum
Year: 2016

description: This article focuses on the Acehnese struggle for self-determination, and the emergence of the Aceh/Sumatra National Liberation Front (ASNLF). Led by Dr. Tengku Hasan M. di Tiro, this movement aims at realizing the historic and democratic quest of the Acehnese who have been colonized under Indonesian hegemony. The struggle of the Acehnese is in keeping with the right of self-determination as defined by international law. The decision on whether Aceh will remain part of the Republic of Indonesia in the form of a loose Indonesian confederation, or become an independent state either in the form of a Commonwealth Independent State of Indonesia or a Confederation of Aceh/Sumatra, should be placed in the hands of the Acehnese.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Die Transition zur Demokratie in Indonesien. Überlegungen zum Systemwechsel vom Ende der 80er Jahre bis zur Gegenwart
Creators: name: Ufen, Andreas
Publisher: name: Internationales Asienforum
Year: 2016

description: This article deals with political developments in Indonesia since 1988, especially since 1997. Priority is given to the description and analysis of four different phases of this transition period (1988-2000). The first phase lasted from the late 1980s until the fall of Suharto. The regime lost its legitimacy, the regime coalition gradually fell apart and the diversified opposition forces gained an ever growing impact upon public debates. These processes accelerated at the beginning of 1998, forcing Suharto fmally to step down. The second phase began with the assumption of office by Habibie and ended with fairly free national elections in June 1999. Although most decisions were made by the conservative government, i.e. by old Suharto followers, the pressure exerted by moderate and radical reformers was strong enough to enforce a significant democratisation. The third phase began in June 1999 and lasted until Abdurrahman Wahid was elected President and formed his coalition government. Ideally, at the end of the last phase the still highly fragile parliamentarian democracy will be sufficiently consolidated.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer
Creators: name: Lin, Rui J.
name: Lubpairee, Tarinee
name: Liu, Kelly Y.
name: Anderson, Donald W.
name: Durham, Scott
name: Poh, Catherine
Publisher: name: BioMed Central
Year: 2015

description: Objectives: To determine the biological characteristics of oropharyngeal squamous cell carcinoma (OpSCC) and related outcome. Design Retrospective study. Methods Patients (N=60) with primary OpSCC from 2000 to 2005 were retrospectively identified from Pathology database and the outcome was confirmed through chart review. Among these, 41 biopsy samples with enough tissues were retrieved to construct a tissue microarray for detection of the presence of high-risk human papillomavirus (HPV) using Chromogenic in situ hybridization (CISH) as well as the expression of p16 and cyclin D1 using immunohistochemistry. Main outcome measures Disease-free survival. Results Among 60 patients, 39 (65%) patients had no recurrence or died without disease at the last follow-up (disease-free survival or Group 1), and 21 (35%) patients had persistent disease or died of disease (progression-free survival or Group 2). Although follow-up time was twice as long in group 1 (4.7 ± 2.2 vs. 2.0 ± 1.6 years; P < 0.0001), there was no difference between the 2 groups in age, gender, smoking/alcohol habits, TNM staging and treatment modalities. Among those 41 cases with available tumour tissues, there was no difference in HPV status and p16 expression between the 2 groups but a significant difference in cyclin D1 expression (P = 0.05). Using Kaplan-Meir survival analysis and log-rank test, cyclin D1 overexpression was highly associated with a poor prognosis when comparing time to outcome (P < 0.0001). Conclusion Cyclin D1 overexpression is a potential prognostic marker of OpSCC.
The Muttahida Qaumi Movement and the Pakistani State
Creators: name: Schied, Michael
Publisher: name: Internationales Asienforum
Year: 2016

description: On 17 September 2000, the Muttahida Qaumi Movement (MQM) presented a number of demands at a public meeting in Acton/London. These demands and the circumstance of their presentation raised a number of questions about the party. The paper shows how the MQM has grown over the past years and explores the very contradictory position of the MQM within Pakistan society and the relationship between the party and the state. It describes the ethnic core of the party which reflects the political realities and structure of the Pakistani state. By so doing the paper also explains the limits of the party and how it differs from the other political forces. It also shows that the Acton meeting was a direct reflection of the situation in Pakistan after the take-over by the military in 1999 and signalled that the crisis of the state and the conflict between the MQM and the state have reached a new climax.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum
Reflective practice and practitioners
Creators: name: Bishop, Peter
name: Morrow, Rowena
Publisher: name: Swinburne
Year: 2024

description: About a year ago, Sohail Inayatullah, Editor of the Journal of Futures Studies, approached the Association of Professional Futurists (APF) with the idea that the Journal would like to affiliate with the Association. The APF was formed in 2003 to serve the foresight practitioner, those who make at least part of their living in the applied practice of futures studies and strategic foresight. So a journal of foresight practice could be a valuable addition to the literature of the field. [Introduction]
Crataegus pinnatifida 'Jinruyi' and 'Ruanzi' genomes
Creators: name: 孟佳欣(Meng Jiaxin)
Publisher: name: CNGB
Year: 2024
Subjects: Assembly
Multispecies
Agricultural

description: Crataegus pinnatifida 'Jinruyi' and 'Ruanzi' genome assembly files for scientific research
The Gendered Organization of Work and Space in the Office Sector in Pakistan
Creators: name: Mirza, Jasmin
Publisher: name: Internationales Asienforum
Year: 2016

description: The article examines the increasing market integration of women, particularly from the lower middle classes, into technical and secretarial occupations in the office sector in urban Pakistan. It shows that gender constructs and gender relations inherent in the social order of Pakistani society - inter alia, the lack of socially sanctioned modes of communication between the sexes, a strong sexualization of gender relations outside the kinship system, and the ubiquitous harassment of women in the public sphere - surface inside the offices. Female office workers use many strategies to accommodate the purdah system and its concepts of gender segregation and female seclusion to the office environment, thereby establishing themselves in a traditionally male field of employment, namely, the office sector.
description: Internationales Asienforum, Bd. 32 Nr. 1-2 (2001): Internationales Asienforum