cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modulation of microtuble dynamics by the microtubule-associated protein MAP1a
Creators: name: Faller, Elliott M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Cell.

description: Structural microtubule-associated proteins (MAPs) are capable of interacting with tubulin dimers to regulate the various dynamic stages of microtubules. MAP1a is predominant in the neuronal cell body, axons and dendrites of mature neurons. MAP1 a has been shown to bind microtubules to promote microtubule assembly in vitro. The MAP1a heavy chain molecule is associated with three light chains. The heavy chain, and all three light chains appear to associate with microtubules independent of each other. The purpose of this project was to measure the impact of myc-tagged MAP1 a fragments and myc-tagged light chains associated with MAP1a on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been permanently transfected with human GFP-alpha tubulin were transiently transfected with myc tagged MAP1a heavy and light chain fragments. Cells expressing MAP1a and light chain fragments were used to make direct observations of microtubule dynamics in living cells using fluorescence microscopy. Microtubule ends were photographed at 4-second intervals using a digital camera over a 2-minute duration. All truncated MAP1 a heavy chain fragments that contained the microtubule-binding domain were shown to associate with microtubules. MAP1a fragments containing portions of the projection domain promoted growth and stability of microtubules. Truncated fragments containing different regions of the projection domain of MAP1a demonstrated variations in their impact on microtubule dynamic events by promoting growth or inhibition of shortening phases. Similar to full length MAP1a, LC3 also appeared to promote microtubule growth and stability. Results from the present study suggest that MAP1a and LC3 promote slow, stable growth of microtubules. This type of growth may be important in the maintenance and restructuring of adult neurons.
The role of Sir2alpha in myogenesis
Creators: name: Abrol, Meena
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Cell.
subject: Chemistry, Biochemistry.

description: Protein acetylation is becoming recognized as an important modification in the regulation of many cellular pathways. The silent information regulator 2 (Sir2) proteins are a family of NAD-dependent protein deacetylases. Sir2 protein function in yeast has extensively been characterized as an essential mediator of gene silencing that occurs at the mating type loci, the telomeres and the rDNA regions. There are Sir2 homologues from yeast to mammals, but little is known about the role of Sir2 in the mammalian system. There is evidence that myogenesis is regulated by the acetylation state of the histones in the promoter region of muscle-specific genes as well as the myogenic transcription factors. MyoD is a myogenic transcription factor that plays a key role in myogenesis. Its activity is required to initiate and maintain transcription of muscle-specific genes. In addition to this, acetylation of MyoD is required for its activity. We set out to determine if MyoD is a target for deacetylation by Sir2alpha, and thus determine if Sir2alpha has a role in myogenesis. We determined that MyoD transactivation activity is not inhibited by Sir2alpha deacetylation. Over-expression of Sir2alpha-wt or a catalytically inactive mutant Sir2alpha-H355Y in C2C12 cells also showed that Sir2alpha deacetylase activity does not effect myogenesis. In addition to this, nicotinamide, a Sir2 inhibitor, had no effect on myogenesis while TSA significantly inhibited myogenesis in the C2C12 cells, suggesting that Class I and II HDACs have a more important role than Sir2 in regulating MyoD activity.
title: Przygotowanie redakcyjne pracy dyplomowej
Creators: name: Szczepaniak, Jolanta
Publisher: name: Wydawnictwo Politechniki Łódzkiej
Year: 2019

description: Poradnik zawiera ogólne wskazówki dotyczące redakcyjnego opracowania tekstu pracy dyplomowej, zarówno do druku, jak i przygotowania postaci cyfrowej.
Wheat Beat Podcast, 2017
Creators: name: WSU Extension Dryland Cropping Systems
Publisher: name: Washington State University
Year: 2017
Subjects: Dryland farming
Agriculture

description: Included here are episodes of Wheat Beat, a podcast created by Washington State University Extension Dryland Cropping Systems.
description: Episodes include:
description: Wireworms with Aaron Esser & Dave Crowder
description: GMOs and CRISPR/CAS with Michael Neff
description: Farm Bill Chat with Randy Fortenbery
description: Low Falling Numbers with Camille Steber and Kim Garland-Campbell
description: Variety Selection & Testing Program with Ryan Higginbotham
description: Climate Resilient Wheat with Kulvinder Gill
description: Wheat Beat to a Different Drum by Karen Sowers and Ian Clark
Recharge and regional circulation of thermal groundwater in northern Jordan using isotope geochemistry.
Creators: name: Bajjali, William Tawfiq.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Geology.

description: The scarcity of water resources in Jordan poses difficulties for the development of the country and its relationship with its neighbours. Thermal groundwaters recently identified in the northern part of the country represent a 40 MCM/y resources for exploitation to meet the increasing demand for water. These thermal groundwaters are found in three well fields (Mukhebeh, JRV and Ramtha) and were investigated to determine their recharge origin, mean subsurface residence times, and the source of heat. They discharge in the northern part of Jordan Rift Valley and the rifted Yarmouk Valley, which are low elevation (50 to 150 m below sea level) zones of recent tectonism and volcanic activity. The range of temperatures is 30 and 56$\sp\circ$C and salinities vary between 500 and 2500 mg/l. Non-thermal groundwaters within the study area have also been studied. In particular shallow groundwater in adjacent highlands region (Ajloun Mountains) are examined to determine their role in recharge to those regional flow systems. The principal aquifer is the Upper Cretaceous B2/A7 group, a package of carbonate formations with high kerogen content at depth. This aquifer outcrops in the Ajloun Mountains and flanking regions and is confined by overlying marls in the down gradient regions. A deeper sandstone aquifer underlies the study area and hosts thermal groundwater which was sampled in the Ramtha area. The major geochemical processes in the subsurface have generated various geochemical facies in the thermal waters. These include carbonate dissolution to calcite saturation in the recharge areas. The thermal groundwater in Mukhebeh and JRV well fields are found to be chemically similar to the carbonate groundwater from Ajloun mountains recharge area. All thermal waters are characterized by sulphate reduction, driven by oxidation of kerogen. Sulphate is of marine evaporite origin dissolved from within the aquifer with a component of volcanogenic sulphur. Some thermal waters have also Na-Cl salinity component related to evaporite dissolution. The thermal waters are of meteoric provenance, originating as rain falling over the carbonate highlands in Jordan and Syria. The $\delta\sp $O and $\delta$D isotopic data show that all thermal groundwaters are largely associated with Eastern Mediterranean Meteoric Water Line, signifying recharge under the climate regime which dominates today in Jordan. The exception is groundwater from the deep sandstone aquifer which is associated with Global Meteoric Water Line, signifying recharge during Pleistocene time. The isotopic composition of groundwater suggests two distinct recharge areas for the Mukhebeh well field: Ajloun Mountains (Jordan) and Mount Hermon (Syria). (Abstract shortened by UMI.)
title: Freedom and the formalization of experience: a Hegelian critique, a Kantian answer
Creators: name: Tucker, Joshua
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2025

description: Georg Wilhelm Friedrich Hegel’s critique of Immanuel Kant’s formalism is highly informative – it brings to light many aspects of morality and ethical decision-making that had gone entirely unnoticed by Kantians until that point, such as the importance of world history in determining our concepts of right, and that the subsumption of particulars under universals does not typically fall to individuals. Because a determination of moral concepts by history itself seems to contradict Kantian morality (in which we use the categorical imperative to determine whether a formulated maxim conforms with duty or not) by eliminating any genuine choice (as the ways in which we formulate our maxims are themselves historical products rather than free decisions), Kantians have responded to Hegel’s critique in part by trying to show that such factors can be accounted for purely within Kantian philosophy. Through examining Hegel’s critique of Kant’s formalism and Kantian philosophy, this thesis will follow this tradition. I will argue that Hegel’s critique must transform how we conceptualize Kant’s philosophy, how we should think of his doctrine of freedom in contrast to determinism, and the sense of objectivity that we can secure with his philosophy. I will argue that the best answer to Hegel’s critique of Kant’s formalism is Kant’s own theory of the end of nature and history and that his writings on history are consistent with the rest of his more speculative work.
Living with Ehlers Danlos Syndrome: An Emerging Adulthood Perspective
Creators: name: Bealka, Kathryn
Publisher: name: Brandeis University
Year: 2018
Subjects: Ehlers Danlos syndrome
Emerging Adulthood
Transition
Genetic Counseling
Relationships
Emotional Impact
Physical Impact

description: Ehlers Danlos syndrome (EDS) is a multi-systemic, genetic, connective tissue disorder. This study is an early look at the specific impacts of hypermobile and classical EDS in the transitional period of life between the ages of 20-30, coined, emerging adulthood. Participants were recruited through support groups across the United States and internationally, and were asked to complete an online survey designed to collect both quantitative and qualitative data that focused on areas of life that are important to emerging adulthood including education, career planning and relationships. A total of 368 participants expressed varying degrees of adjustment to a diagnosis of EDS. Specific challenges that were highlighted by participants included an impact on relationships with family, friends and romantic partners based on an individual’s severity of symptoms, number of symptoms and current age, as well as experiencing negative physical and emotional impacts of EDS. These results suggest the need for medical professionals to support their patients in a multitude of ways and to be sensitive to this time of transition for those with EDS.
Purification of Escherichia coli YoaA, a Putative Helicase
Creators: name: Gregory, Mark
Publisher: name: Brandeis University
Year: 2019

description: All cells must maintain their genomic integrity to survive. Several repair mechanisms necessitate unwinding the damaged DNA to allow the recruitment of repair factors. Unwinding activity is achieved by helicases which temporarily destabilize the DNA duplex. When this function fails, human diseases such as Werner Syndrome, Xeroderma Pigmentosum, and Trichothiodystrophy can result. The role of helicases is integral to DNA repair in prokaryotic organisms as well. In Escherichia coli (E. coli), helicases including the RecBCD complex, RecQ, and DinG are utilized to unwind regions of double stranded DNA to make it accessible to repair factors. The SOS response is a system of inducing genes that aid in repairing damaged DNA in E. coli. Though this system has been well characterized, the picture may be incomplete. YoaA is a putative helicase because it shares conserved sequences with damage-inducible helicase DinG and has been shown genetically to be involved in DNA repair. The goal of this study is to develop a system that will allow the purification of YoaA. In our original system, YoaA expression in a high copy plasmid resulted in cell toxicity. In the expression system presented herein, YoaA was fused to a N-terminal RGS-His6 tag (6XHisYoaA) and overexpressed in a low-copy vector under the lacZ promoter. This resulted in a stable form of YoaA. To purify 6XHisYoaA, the Nickel-NTA, single-stranded-DNA, and MonoQ columns were chosen and tested based on the protein’s biochemical and ionic properties. The method that proved to be the most promising in allowing us to purify 6XHisYoaA was utilizing the Nickel-NTA column then the MonoQ column.
Supplementary document for Inversed-design of microstructure for vortex beams generation via perturbative backpropagation neural network - 7273610.pdf
Creators: name: Zhang, Xinyang
name: Hu, Junzheng
name: Dong, Renwu
name: ZHOU, ZHUOYAN
name: Li, Shiqi
name: Li, Haotian
name: Zhan, Peng
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The design of microstructures
Semantic Parsing in Spoken Language Understanding using Abstract Meaning Representation
Creators: name: Shen, Hongyuan
Publisher: name: Brandeis University
Year: 2018
Subjects: SLU, AMR, annotation, semantic parsing, grounding, NLP

description: With the increasing interest in Spoken Language Understanding (SLU) related applications such as voice assistant and automated answering system, we aim to find a better system solution for such tasks, in particular, concentrating on the semantic parsing procedure that transforms the spoken language into a Meaning Representation Language (MRL) where only the semantic meaning and logistic relations in the word span are preserved. The viability of the stage in SLU known as "grounding" between our proposed MRL, Abstract Meaning Representation (AMR) language, and computer- interpretable commands is also analyzed in this thesis. To assist with the planned experiments, the first AMR corpus that is populated with spoken language transcription is created by manual annotation, providing as a reference for future studies on SLU- oriented AMR parsing tasks.
(somewhere) in the middle
Creators: name: Nguyen, Nhat
Publisher: name: Brandeis University
Year: 2023

description: “(somewhere) in between” involves three characters, including a main character and two side characters portrayed by the bass flute, bass clarinet and electric guitar accordingly. Because the two side characters do not evolve so much in terms of their sound world, the focus is then turned to the bass flute, who goes through a journey of imitations of the other two characters.
Regulated EMRE protein level in the Mitochondrial Calcium Uniporter
Creators: name: Wu, Yujiao Jr
Publisher: name: Brandeis University
Year: 2016
Subjects: Mitochondrial Calcium Uniporter
EMRE
m-AAA protease
quality control

description: Mitochondrial Calcium Uniporter serves as the major portal for calcium influx into the matrix. It is a highly regulated ion channel complex composed of the pore forming subunit MCU and multiple regulatory subunits, among which the Essential MCU REgulator (EMRE) is necessary for the calcium conducting function of MCU. The goal of this work is to understand how cells regulate EMRE expression level. Using a cycloheximide chase assay, I found that MCU protects EMRE from rapid proteolysis by the mitochondrial m-AAA (ATPases Associated with diverse cellular Activities) protease. Experiments show that such protection requires interactions between the two proteins’ transmembrane helices (TMHs). Then I use EMRE homologues and chimeras to show that the rate-limiting step for EMRE degradation occurs after initial protease binding to the EMRE’s N-terminus. This work revealed a post-translational mechanism by which balanced expression of uniporter subunits is achieved, a condition that might be crucial for proper assembly of the uniporter complex.
Evaluation of risk factors associated with diminished immune response to Haemophilus influenzae type b PRP-D vaccine among Inuit infants of the Northwest Territories.
Creators: name: Williamson, Nancy Jean.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Health Sciences, Public Health.

description: Haemophilus influenzae type b (Hib) is the most important cause of serious invasive bacterial disease in young children in many countries, particularly industrialized countries. A 1986 study using PRP-D vaccine among Aboriginal infants in the Northwest Territories (N.W.T.) reported that all ethnic groups responded poorly, but the proportion of Inuit (44%) who responded with protective anti-PRP antibody levels of $\geq0.15\ \mu$/mL was smaller than that of the Dene (60%). This study was undertaken to explore possible reasons for the poorer results of the Inuit infants. Results. The results suggested that the difference between two vaccine lots and sex, and possibly age and region, were implicated in the difference between the groups. Conclusions. The research did not entirely achieve a resolution of the part which ethnicity and other factors played in Inuit response to PRP-D vaccine. The importance of the study, however, was that, by examining the data in more detail, factors other than ethnicity were identified as potentially having an effect on the poor immune response of the Inuit infants in the 1986 N.W.T. study. (Abstract shortened by UMI.)
Accounting Information System Coordination
Creators: name: Molanazari, Mahnaz
name: Ateffe Zarabi
Publisher: name: figshare
Year: 2020
Subjects: subject: 150105 Management Accounting
subject: FOS: Economics and business
subject: 150199 Accounting, Auditing and Accountability not elsewhere classified
subject: 150102 Auditing and Accountability
subject: 150103 Financial Accounting

description: In today's world, the fast access to information has an essential role on sustainable development of economic institutions and user’s economic decision making. Knowing how to quickly deal with the company’s events, and identify problems and opportunities is important for executives of banks, companies and institutions. The accounting information system is a powerful tool to improve the efficiency and effectiveness of the reporting process. As companies need to expand their information level in uncertain conditions of competitive market, they need to upgrade their information system in order to coordinate the needs and their information processing capacity. So we focus on the coordination of needs and information processing capacity and factors affecting this coordination. In addition the underling theory of this coordination is studied. This is important because previous research emphasis on effect of the coordination of needs and information processing capacity on company’s performance. In fact each company needs a coordinated information system in order to obtain information correctly. The coordination of accounting information systems enables companies to comply system users and manager’s expectations, then it improves company’s performance
Comparative study of attenuation and dispersion of different pressure disturbances propagating in aerosols
Creators: name: Jo, Riady Siswoyo
name: Wong, Basil T.
name: Vakhguelt, Anatoli
Publisher: name: Swinburne
Year: 2024

description: This study aims to investigate the attenuation and dispersion of pressure waves propagating in aerosols. A numerical scheme based on Crank-Nicolson finite differencing and trapezoidal quadrature discretization methods is employed to simulate the evolutions of several pressure waves with different initial profiles (disturbances). The attenuation and dispersion are observed from the spectra of the wave profiles at different times of propagation obtained by performing FFT (Fast Fourier Transform) to the simulated wave profiles. Simulation results show distinctive behaviors of different pressure disturbances propagating through the same medium.
Target Deconvolution of a Mechanistically Distinct Mtb Inhibitor
Creators: name: Marqus, Gary Michael
Publisher: name: Brandeis University
Year: 2023
Subjects: benzoxazole
fluorescent d-amino acids
mycobacterium tuberculosis
peptidoglycan
photoaffinity label
Target identification

description: Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), an infectious disease that is responsible for over 1.5 million deaths annually across the globe. Drug resistant and extensively drug resistant strains have rendered many frontline treatments less effective, resulting in an urgent need for new drugs and targets. The Hedstrom lab has been focused on the development of anti-mycobacterial inhibitors for two decades. A family of benzoxazole compounds (Q compounds) have proven to be effective inhibitors of Mtb. Q112 is a potent inhibitor of Mtb and has a novel mechanism of action. The identification of novel targets and mechanistic pathways is vital towards the development of new TB drugs. Herein, we report that Q112 uniquely perturbs peptidoglycan biosynthesis and may also target fatty acid biosynthesis in Mycobacteria.
Simple geometric constructs for routing and boundary detection in sensor networks
Creators: name: Fayed, Marwan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Computer Science.

description: Micro-sensor and radio technologies now permit the manufacture of cheap sensor or embedded devices deployable en masse. Applications appear in a diverse set of environments for far reaching applications including but not limited to structural monitoring, target tracking, and early warning systems. When deployed to create a sensor network, have no foreknowledge of their environment. In a network of this type traditional networking techniques are unsuitable. In general, sensing and embedded devices are shaped by four constraints: limited power supply, small memory, unattended operation, and the error-prone nature of wireless communications. Our work is motivated by the hypothesis that within view of each node are geometric features that impact network characteristics and behaviour. The central objective in this thesis is to investigate the geometry of the network graphs. Doing so allows us to identify some of the unique features of the network that constrain larger problems. We first propose boundary detection solutions using two well-known structures. First with the convex hull we build a localised heuristic, local convex view (lcv), that is designed on the premise that a node on the convex hull of a small region of the network is likely on the convex hull of the whole network. We show positive results via analysis and simulation and discover that the geometric properties are directly responsible for its resilience to error. We propose further the alpha-hull. whose structure can reveal details in the 'shape' of a set of points. We find that by selecting the alpha-parameter carefully, it is possible to infer the network-wide alpha-hull from local communications and computations. We also investigate the limits of routing according to left- or right-hand rule (LHR). Using LHR, a node upon receipt of a message will forward to the neighbour that sits next in counter-clockwise order in the network graph. When used to recover from greedy routing failures, LHR guarantees success if implemented over planar graphs. We identify network constraints that lead us to propose the Prohibitive-link Detection and Routing Protocol (PDRP) that can guarantee delivery over non-planar graphs. As the name implies, the protocol detects and circumvents 'bad' links. Our implementation of PDRP reveals the same level of service as face-routing protocols despite preserving most intersecting links in the network.
title:  Insegnare la variazione. La certificazione per misurare le competenze linguistiche degli studenti italofoni per i livelli B1 e B2.
Creators: name: Abdelsalam, Rania
name: Solimando, Cristina
Publisher: name: RomaTrE-Press
Year: 2018

description: Il quadro comune europeo per la conoscenza delle lingue (QCER), messo a punto dal Consiglio d’Europa nel 2001, e divenuto oggi lo strumento di valutazione utilizzato per le lingue europee, ha messo in luce l’importanza dell’aspetto comunicativo sia nella didattica delle lingue sia in ambito di valutazione. I mutamenti che la società europea sta affrontando, principalmente a seguito del fenomeno immigratorio, hanno spinto i docenti di lingua araba a interrogarsi sulla possibile adozione del QCER come strumento di valutazione anche per la lingua araba. Dopo aver analizzato le principali problematiche legate al suo adattamento all’arabo, il presente contributo intende presentare le linee generali di un progetto di ricerca relativo alla certificazione delle competenze linguistiche per i livelli B1 e B2. Esso propone di introdurre il FSA (Formal Spoken Arabic) accanto al MSA nell’insegnamento universitario, e ciò allo scopo di rendere il discente consapevole della variazione linguistica presente nella realtà arabofona.
description: Didattica dell’arabo e certificazione linguistica: riflessioni e iniziative
The Search for Purpose: Henry Kissinger's Early Philosophy and American Foreign Policy
Creators: name: Moseley, Lauren
Publisher: name: Brandeis University
Year: 2010

description: The thesis, "The Search for Purpose: Henry Kissinger's Early Philosophy and American Foreign Policy," argues that while Kissinger's decisions post-1968 were incredibly important in shaping the United States' position in the world and his own reputation, these decisions are contingent upon the “intellectual capital” he developed before joining the Nixon administration. This "intellectual capital" is well-documented in written form and includes Kissinger's sophisticated undergraduate honors thesis, his graduate dissertation later published as the book A World Restored, and the numerous scholarly books and articles he wrote on American foreign policy before his appointment as Nixon's national security advisor. \\tThis thesis argues that an understanding of Kissinger's early writings is important because they reveal an embrace of an idealistic philosophy that overshadowed the political realism he is more well-known for. His constant calls for vision, purpose, inspiration and intuition were concepts deeply rooted in the idealistic philosophy through which he understood the world. Kissinger's philosophy pervaded each of his early works—from his writings as student and academic to critiques of American foreign policy as a scholar, and memos and letters as a member of President John F. Kennedy's administration. The aim of this thesis is to point out a commonly misinterpreted or ignored aspect of Kissinger's worldview as expressed in these early writings. This aspect is one that deeply contrasts with Kissinger's reputation as a cold-blooded practitioner of Realpolitik and an enthusiast of the political philosophy of realism. The analysis of Kissinger's early writings will highlight four strains of his idealistic thought which can be traced through “The Meaning of History,” A World Restored, and his writings on American foreign policy: optimism for human nature, agency of the individual, the struggle towards ideals within limits, and purposeful action. This thesis concludes that Kissinger's early idealistic thoughts contrast sharply to his reputation as a practitioner of Realpolitik.
Stumbling blocks: Geopolitics, the Armenian Genocide, and the American Jewish community
Creators: name: Harris, Jason
Publisher: name: Brandeis University
Year: 2008
Subjects: Jewish and Armenian Genocide
United States Congress and Armenian Genocide
Israel and Armenian Genocide
Henry Morgenthau and Armenian Genocide
Rabbi Stephen Wise and Armenian Genocide
Jewish community and geopolitics
Jews and Armenian Genocide
Armenian Genocide
Jews and Armenia
Jewish community and United States Congress
Jewish community and Armenian Genocide

description: In 2007 the standout political issue for the American Jewish community was whether or not to support a congressional resolution recognizing the Armenian Genocide of 1915. How did global political complexities intrude on such a seemingly simple matter? What is the past history between the Armenian people and the American Jewish community? And what are the wider implications of this controversy? \r \r This paper considers the above questions across three sections. The first delves into Armenian history, noting in particular where the Armenian story abuts the Jewish one. This section also surveys the 1890s Hamidian massacres and American Jewry’s role in what became America’s first international humanitarian relief effort.\r \r The second part examines the Armenian Genocide, from the rise of the Young Turks to the aftermath of World War One, which resulted in the creation of the modern Republic of Turkey and the absorption of Armenia into the Soviet Union. Certain Jewish heroes emerge, such as Ambassador Henry Morgenthau, Raphael Lemkin, and Rabbi Stephen Wise, who, among others, endeavored to report on the Genocide and raise American consciousness about the fate of the Armenians. This paper also looks at comparisons between the Holocaust the Genocide and the efforts of modern-day Turkey to deny the Genocide and thwart recognition efforts.\r \r The third section considers the contemporary politics that make Genocide-recognition so difficult. Concerns about American and Israeli national security, the fate of Turkey’s Jewish community, and the desire to preserve Holocaust “uniqueness” intrude upon what many in our community consider to be a purely moral question. Ultimately, this paper leaves it to the reader to consider the dilemma between acting “righteous” and “practical.”
Perspectives on Computation in Oscillatory Networks in the Brain
Creators: name: Sanders, Honi
Publisher: name: Brandeis University
Year: 2016
Subjects: Hippocampus
Neuroscience

description: This thesis explores possible roles of oscillations in the brain. Computer simulations demonstrate the robustness of dendritic voltage bistability, a mechanism for working mem- ory, when including GABAB-activated internal-rectifying potassium channels (Ch. 11). This mechanism is employed in a biophysically realistic neuronal network model that is capable of transforming a temporally extended sequence of inputs into a simultaneously represented spatial pattern of output (Ch. 22). Such a transformation is necessary as many external inputs or internal communications in the brain last longer than any individual neuron can process. This transformation relies on the discretizing potential of oscillations for segmenting multi-part messages, which is the first role discussed. The second role arises from recent work on the rodent hippocampus that has called past models into question. A theory is proposed here in which the two halves of theta-frequency oscillations have distinct processes associated with them: in the first half of each theta cycle, current experience is represented, and in the second half of each theta cycle, predictions of upcoming locations are made (Ch. 33). Anal- ysis of recordings from rat hippocampus during behavior demonstrates that two phenomena exhibited by hippocampal place cells, rate remapping and phase precession, dominate dur- ing di↵erent halves of the theta cycle (Ch. 4, in preparation). This work elaborates on the possible role of oscillations in temporally organizing multi-part computations.
Approach to coverage-driven functional verification of complex multimillion gate ASICs
Creators: name: Hermas, Wael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: Today ASICs' designs are very complex and each consists of multi-millions gates. This creates a difficult and almost an impossible task for the verification engineers to verify thoroughly the whole design. The complexity of the verification effort grows exponentially. The most common verification methodology used today is Deterministic Testing. Based on today large designs, hundreds of deterministic test cases are required to verify the whole design. This is very time consuming and it requires lots of engineers' manpower. Since time to market is very essential, the engineers are forced to send the ASIC for fabrication even though lots of functionalities are not covered. A solution to this problem is Coverage-Driven Functional Verification (CDV). The CDV approach is based on ASICs functionalities. The verification process is done in the early stages of the design. In fact it is done right after the ASICs specifications are outlined and in parallel with RTL development. Functional Coverage is performed by collecting coverage items that correspond to ASICs functionalities. Using Functional coverage would minimize the number of test cases and enhance the verification process. In this thesis, the "Ethernet IP Core" Verilog design from OpenCores will be used. The Ethernet IP Core is a 10/100 Media Access Controller (MAC). It consists of a synthesizable Verilog RTL core that provides all features necessary to implement the Layer 2 protocol of the Ethernet standard. Both the Deterministic Testing Approach and the Coverage-Driven Functional Verification will be applied on the Ethernet IP Core design. Both verification methodologies will be compared and a conclusion will be driven to prove that CDV is the way for verifying today complex multi-millions gates ASICs. Cadence Specman (e language - IEEE 1647 e) is chosen as the verification tool because it provides different features for the Coverage-Driven Functional Verification Methodology.
Direct arylation of aromatic rings using palladium catalysis
Creators: name: Caron, Laurence
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Inorganic.
subject: Chemistry, Organic.

description: The first section illustrates the novel route to access the biphenyl motif. Starting from simple materials, nitroarenes and aryl halides, we are able to obtain different cross-coupled products in good to moderate yields using palladium as a catalyst. The optimization of the reaction conditions as well as the various biaryl motifs obtained are described.* The second section summarizes our efforts towards the development of universal reaction conditions that can be used for the arylation of a wide range of heterocycles. Although direct arylation products are available in the literature, no broadly accessible method is available yet. The heterocycles described are limited to azoles and the various motifs obtained are illustrated.* *Please refer to dissertation for diagrams.
Genetic susceptibility to orofacial clefts
Creators: name: Johnson, Candice Y
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Genetics.
subject: Health Sciences, Medicine and Surgery.

description: Background. Nonsyndromic oral clefts are some of the most common birth defects, affecting approximately one of every 600 births. Their etiology is not well understood but is thought to involve both genetic and environmental risk factors. Three studies were undertaken to explore the contributions of genetic and environmental risk factors and gene-environment and gene-gene interactions to oral cleft etiology. Methods. The three studies were: a systematic review of complex segregation analyses of nonsyndromic oral clefts; systematic reviews and meta-analyses on the role of folate in oral cleft etiology; and a case-parent triad analysis to investigate gene-environment and gene-gene interactions. Results and conclusions. Genetic and environmental factors were found to be involved in oral cleft etiology; gene-environment and gene-gene interactions were also found to be important. Studying interactions in addition to genetic and environmental factors alone may help to understand the etiology of these complex traits.
Environmental correlates of avian species richness over southern Ontario, Canada.
Creators: name: Muller, Michael René.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Ecology.

description: Species richness is an ecologically important descriptor of ecosystems and, as a component of biodiversity, may be useful for conservation planning. Global and local patterns of richness have been related, with moderate success, to climatic and habitat parameters respectively. However our ability to predict species richness breaks down at intermediate scales (quadrats 10$\sp0$-10$\sp3$ km$\sp2$ in size extending over regions of 10$\sp3$-10$\sp6$ km$\sp2$). We examined the spatial variation in breeding bird species richness in 100 km$\sp2$ squares, across 200,000 km$\sp2$ of southern Ontario, and tested for relationships with a suite of environmental variables that included, climate, human population, land cover, a heterogeneity index, soil fertility and parkland. We conclude that at this spatial scale, the variation in total avian species richness over southern Ontario is not sufficiently well related to either temperature or habitat to warrant further investigation of possible mechanistic links. The richness of certain guilds, however, shows some promise as a possible measure for conservation planning and management. (Abstract shortened by UMI.)
ВЛИЯНИЕ КОРОНАВИРУСНОЙ ИНФЕКЦИИ НА КЛИНИЧЕСКОЕ  ТЕЧЕНИЕ РЕВМАТОИДНОГО АРТРИТА
Creators: name: Абдуазизова, Наргиза
name: Шарапов, Зафар
Publisher: name: Zenodo
Year: 2025

description: Ревматоидный артрит (РА) — ревматологическое заболевание, сопровождающееся суставным синдромом, функционально характеризующееся эрозивным поражением и деструкцией суставов. Заболевание встречается преимущественно у лиц молодого и среднего возраста и приводит к ранней инвалидизации больных, что в свою очередь определяет социальную значимость и актуальность проблемы. Инфекция COVID-19 обусловила новые черты течения РА, что определяет медицинскую и социальную актуальность изучения проблемы.
Turquie: Hijab, refus ou reinvention de la modernite
Creators: name: Kharrat, Sana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Women's Studies.
subject: Sociology, Social Structure and Development.

description: Cette these a pour objectif de comprendre le retour du port du voile chez les jeunes femmes turques, en particulier les etudiantes universitaires. Dans cette these nous voulons demontrer que la question de la femme est au coeur de tout projet de civilisation. Depuis l'Empire ottoman jusqu'a aujourd'hui, la place de la femme au sein de la societe est debattue autour des notions prive/public; Orient/Occident; islam/laicite; identite/egalite; modernite/tradition. L'analyse sociologique basee sur une definition d'une modernite fondee sur un presuppose d'une histoire evolutionniste et universaliste montre ses limites quand on veut expliquer l'appropriation de la modernite par les jeunes femmes voilees dans un espace extra-europeen. Le port du foulard met en effet en evidence un nouveau profil de la femme musulmane, celle qui evolue dans des espaces regis par les valeurs de la modernite. Il s'agit de comprendre le nouveau phenomene du port du voile non pas comme un simple retour a une tradition archaique ou plus exactement a un refus d'une modernite imposee depuis l'edification de la Republique turque mais d'essayer de comprendre les significations contemporaines de celui-ci. Ainsi, le hijab est devenu le symbole de la politisation de l'islam, mais il exprime aussi l'emergence d'un nouvel individu feminin en quete de difference et d'identite dans l'egalite.
Structure-function studies in antibodies and glycosyltransferases
Creators: name: Landry, Roxanne C
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Chemistry, Biochemistry.

description: Protein-protein and protein-carbohydrate recognition are key to understanding many critical life processes. One such critical life process is host defense, and the determination of the crystal and molecular structures of complexes involved in synthesizing and recognizing clinically-relevant antigens can provide key insight into fields as diverse as immunotherapy or chemo-enzymatic synthesis. In the first part, immunotherapeutic antibody candidates MR1 and BEC2 were studied to gain a structural understanding of their potential in the prevention and treatment of cancer. Antibody MR1 binds specifically and with high-affinity to a mutant of the epidermal growth factor receptor (EGFRvIII) defined by an in-frame deletion that generates a novel glycine residue at the fusion junction. It was our hypothesis that this fusion junction glycine residue would form a key recognition element for antibody MR1. The x-ray crystal structure of MR1 in complex with a peptide antigen of the EGFRvIII shows MR1 to possess a J-shaped groove and the EGFRvIII peptide to adopt a hairpin turn---beta strand conformation. Interestingly, the fusion junction glycine, although a central feature of the EGFRvIII peptide, does not interact specifically with MR1 but allows the hairpin turn, which is both unique to EGFRvIII and crucial for MR1 recognition. Antibody BEC2 is an anti-idiotypic antibody mimic of the tumor-associated GD3 ganglioside. It has been raised against anti-GD3 antibody R24 and used successfully to immunize hosts that natively express the antigen against GD3. It was our hypothesis that key polar groups of BEC2 would structurally mimic the GD3 antigen; however, several endeavors including isolation of R24-like antibodies for crystallization, purification of digested fragments of BEC2, and expression of BEC2 and R24 antibody constructs have all failed to yield sufficient amounts of quality protein for crystallization. In the second part, the structures of mutants of the ABO(H) blood group glycosyltransferase B were solved to gain a greater understanding of substrate specificity and mechanism of catalysis. The x-ray crystal structures of cysteine-to-serine mutants GTB M2 (C80S, C196S) and GTB M3 (C80S, C196S, C209S) show a more ordered catalytic domain with a novel helix being observed as compared to the heavy-atom derivative of wild-type GTB. The addition of the third C-to-S mutation in GTB M3 brings about ordering of the catalytic loop, a loop that is not observed in any of the GTB structures published to date. The C2095 mutation allows two water molecules to position themselves in the active site cleft, with one of these waters bridging S209 to a residue important in donor binding, R188. This bridging interaction locks R188 in one position where R188 can interact with the DXD motif D211 and D302.
Communication processes in dressage coaching.
Creators: name: Cumyn, Lucy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Speech Communication.

description: The purpose of this thesis was to study the communication processes in the equestrian sport dressage. Phase One was a descriptive, qualitative study examining the pathways of communication. This involved interviewing one coach and two dressage riders. From the results, we made a preliminary model of communication that included three actors (coach, rider, and horse) and different pathways of communication (auditory, kinesthetic, verbal, visual). In Phase Two, we interviewed a second coach and two more riders. We decided to look at their definition of dressage as well as the culture within which we could study communication, as it would bring a deeper understanding of the participant's environment. Here, the role of the horse was more important than we initially thought, and the kinesthetic pathway was key to successful dressage riding and training. Phase Three was a detailed study looking at different levels of riders and horses and how the process of communication differed within each context. The roles of each actor were also studied. A cross context analysis was done and a detailed look between the six different contexts revealed several interesting similarities and differences.
Phytochemical basis for the anxiolytic activity of the ayurvedic medicinal plant Centella asiatica (L) Urb (gotukola)
Creators: name: Wijeweera, Priyantha
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Health Sciences, Mental Health.
subject: Health Sciences, Pharmacology.
subject: Chemistry, Biochemistry.
subject: Biology, Plant Physiology.
subject: Psychology, Physiological.

description: Gotukola (Centella asiatica L. Urban) (Apiaceae), its extracts and the pure compound asiaticoside were studied for anxiolytic activity in thirteen standardized rat trials. High performance liquid chromatography (HPLC) was used to conduct the phytochemical analysis. Among different models tested, the most promising positive response for anxiolytic activity was observed in the elevated plus maze test conducted with: (a) whole plant materials, (b) ethyl acetate and methanol fractions and (c) asiaticoside. The results show for the first time that asiaticoside and triterpene enriched fractions of gotukola have anxiolytic effects in animal models. Therefore, they are recommended for clinical trials. The findings of this study also support the ayurvedic use of gotukola for psychiatric disorders. Other supplementary investigations conducted show that methyl jasmonate and full sunlight enhance the expression of asiaticoside in gotukola plants. The stolon explants were more successful compared to the leaf explants in in vitro propagation of gotukola.
Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori
Creators: name: Ra, Seung W.
name: Sze, Marc A.
name: Lee, Eun C.
name: Tam, Sheena
name: Oh, Yeni
name: Fishbane, Nick
name: Criner, Gerard J.
name: Woodruff, Prescott G.
name: Lazarus, Stephen C.
name: Albert, Richard
name: Connett, John E.
name: Han, Meilan K.
name: Martinez, Fernando J.
name: Aaron, Shawn D.
name: Reed, Robert M.
name: Man, S. F. P.
name: Sin, Don D.
Publisher: name: BioMed Central
Year: 2017

description: Background: Helicobacter pylori (HP) infection is associated with reduced lung function and systemic inflammation in chronic obstructive pulmonary disease (COPD) patients. Azithromycin (AZ) is active against HP and reduces the risk of COPD exacerbation. We determined whether HP infection status modifies the effects of AZ in COPD patients. Methods: Plasma samples from 1018 subjects with COPD who participated in the Macrolide Azithromycin (MACRO) in COPD Study were used to determine the HP infection status at baseline and 12 months of follow-up using a serologic assay. Based on HP infection status and randomization to either AZ or placebo (PL), the subjects were divided into 4 groups: HP+/AZ, HP-/AZ, HP+/PL, and HP-/PL. Time to first exacerbation was compared across the 4 groups using Kaplan-Meier survival analysis and a Cox proportional hazards model. The rates of exacerbation were compared using both the Kruskal-Wallis test and negative binomial analysis. Blood biomarkers at enrolment and at follow-up visits 3, 12, and 13 (1 month after treatment was stopped) months were measured. Results: One hundred eighty one (17.8%) patients were seropositive to HP. Non-Caucasian participants were nearly three times more likely to be HP seropositive than Caucasian participants (37.4% vs 13.6%; p < 0.001). The median time to first exacerbation was significantly different across the four groups (p = 0.001) with the longest time in the HP+/AZ group (11.2 months, 95% CI; 8.4–12.5+) followed by the HP-/AZ group (8.0 months, 95% CI; 6.7–9.7). Hazard ratio (HR) for exacerbations was lowest in the HP+/AZ group after adjustment for age, sex, smoking status, ethnicity, history of peptic ulcer, dyspnea, previous hospital admission, GOLD grade of severity, and forced vital capacity (HR, 0.612; 95% CI, 0.442–0.846 vs HR, 0.789; 95% CI, 0.663–0.938 in the HP-/AZ group). Circulating levels of soluble tumor necrosis factor receptor-75 were reduced only in the HP+/AZ group after 3 months of AZ treatment (−0.87 ± 0.31 μg/L; p = 0.002); levels returned to baseline after discontinuing AZ. Conclusions: AZ is effective in preventing COPD exacerbations in patients with HP seropositivity, possibly by modulating TNF pathways related to HP infection.