cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The University of British Columbia Announcement of the Summer Session Tenth Session July 2nd to August 24th, 1929 Vancouver, British Columbia
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 10th summer session at the University of British Columbia, taking place from July 2nd to August 24th, 1929. Contains course schedule, course descriptions and details, fees, and other information about the session.
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00652
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00652, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
Inference of magnetic fields in the very quiet Sun
Creators: name: González, M. J. Mart\' inez
name: Yabar, A. Pastor
name: Lagg, A.
name: Ramos, A. Asensio
name: Collados, M.
name: Solanki, S. K.
name: Balthasar, H.
name: Berkefeld, T.
name: Denker, C.
name: Doerr, H. P.
name: Feller, A.
name: Franz, M.
name: Manrique, S. J. Gonzaález
name: Hofmann, A.
name: Kneer, F.
name: Kuckein, C.
name: Louis, R.
name: von der Luühe, O.
name: Nicklas, H.
name: Orozco, D.
name: Rezaei, R.
name: Schlichenmaier, R.
name: Schmidt, D.
name: Schmidt, W.
name: Sigwarth, M.
name: Sobotka, M.
name: Soltau, D.
name: Staude, J.
name: Strassmeier, K. G.
name: Verma, M.
name: Waldman, T.
name: Volkmer, R.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present high-precision spectro-polarimetric data with high spatial resolution (0.4$''$) of the very quiet Sun at 1.56$μ$m obtained with the GREGOR telescope to shed some light on this complex magnetism. Half of our observed quiet-Sun region is better explained by magnetic substructure within the resolution element. However, we cannot distinguish whether this substructure comes from gradients of the physical parameters along the line of sight or from horizontal gradients (across the surface). In these pixels, a model with two magnetic components is preferred, and we find two distinct magnetic field populations. The population with the larger filling factor has very weak ($\sim$150 G) horizontal fields similar to those obtained in previous works. We demonstrate that the field vector of this population is not constrained by the observations, given the spatial resolution and polarimetric accuracy of our data. The topology of the other component with the smaller filling factor is constrained by the observations for field strengths above 250 G: we infer hG fields with inclinations and azimuth values compatible with an isotropic distribution. The filling factors are typically below 30\%. We also find that the flux of the two polarities is not balanced. From the other half of the observed quiet-Sun area $\sim$50\% are two-lobed Stokes $V$ profiles, meaning that 23\% of the field of view can be adequately explained with a single constant magnetic field embedded in a non-magnetic atmosphere. The magnetic field vector and filling factor are reliable inferred in only 50\% based on the regular profiles. Therefore, 12\% of the field of view harbour hG fields with filling factors typically below 30\%. At our present spatial resolution, 70\% of the pixels apparently are non-magnetised.
description: published in A&A
Additional file 10: of ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
Creators: name: Dumortier, Mandy
name: Ladam, Franck
name: Damour, Isabelle
name: Vacher, Sophie
name: Bièche, Ivan
name: Marchand, Nathalie
name: Launoit, Yvan De
name: Tulasne, David
name: Chotteau-Lelièvre, Anne
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Figure S8. Metastasis-free survival analysis from the publicly available NKI datasets of breast tumors. a Metastasis-free survival (MFS) curves for patients with breast tumors according to Low-ETV4 (n = 12), High-ETV4 and Low-MMP13 (n = 243), or High-ETV4 and High-MMP13 (n = 9) mRNA levels. ****P ≤ 0.0001. b Metastasis-free survival (MFS) curves for breast tumor patients according to Low-MMP13 (n = 255) or High-MMP13 (n = 9) mRNA levels. ****P ≤ 0.0001. c Metastasis-free survival (MFS) curves for patients with breast tumors according to Low-ETV4 (n = 13) and High-ETV4 (n = 251) mRNA levels. ****P ≤ 0.0001. (PDF 19 kb)
Additional file 26 of Comparative functional genomics analysis of cytochrome P450 gene superfamily in wheat and maize
Creators: name: Li, Yixuan
name: Wei, Kaifa
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 26: Figure S18. Expression profiles of TaCYP450s and ZmCYP450s under drought stress. A. a. Hierarchical clustering of the expression profiles of TaCYP450s based on log2-transformed (TPM + 1) values under drought. b. Heat map of log2-fold change of TaCYP450s. B. a. Hierarchical clustering of the expression profiles of ZmCYP450s based on log2-transformed (TPM + 1) values under drought. b. Heat map of log2-fold change of ZmCYP450s.
Topological Defects in an Open Universe
Creators: name: Spergel, David N.
name: Pen, Ue-Li
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: (To appear in Nuclear Physics B Supplements Proceedings section) This talk will explore the evolution of topological defects in an open universe. The rapid expansion of the universe in an open model slows defects and suppresses the generation of CBR fluctuations at large angular scale as does the altered relationship between angle and length in an open universe. Defect models, when normalized to COBE in an open universe, predict a galaxy power spectrum consistent with the galaxy power spectrum inferred from the galaxy surveys and do not require an extreme bias. Neither defect models in a flat universe nor standard inflationary models can fit either the multipole spectrum or the power spectrum inferred from galaxy surveys.
description: 11 pages and 4 figures, Elsevier Publisher's LaTeX, POP-546
Additional file 2: of Mild clinical features of isolated methylmalonic acidemia associated with a novel variant in the MMAA gene in two Chinese siblings
Creators: name: Yiming Lin
name: Chunmei Lin
name: Weihua Lin
name: Zhenzhu Zheng
name: Mingya Han
name: Qingliu Fu
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 60506 Virology

description: Table S2. Shortlist of seven variants identified in MMA-related genes by targeted NGS. (DOC 35 kb)
A Comparison of the Use of Binary Decision Trees and Neural Networks in Top Quark Detection
Creators: name: Bowser-Chao, David
name: Dzialo, Debra L.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The use of neural networks for signal vs.~background discrimination in high-energy physics experiment has been investigated and has compared favorably with the efficiency of traditional kinematic cuts. Recent work in top quark identification produced a neural network that, for a given top quark mass, yielded a higher signal to background ratio in Monte Carlo simulation than a corresponding set of conventional cuts. In this article we discuss another pattern-recognition algorithm, the binary decision tree. We have applied a binary decision tree to top quark identification at the Tevatron and found it to be comparable in performance to the neural network. Furthermore, reservations about the "black box" nature of neural network discriminators do not apply to binary decision trees; a binary decision tree may be reduced to a set of kinematic cuts subject to conventional error analysis.
description: 14pp. Plain TeX + mtexsis.tex (latter available through 'get mtexsis.tex'.) Two postscript files avail. by email
Predictions for cross sections of light proton-rich isotopes in $^{40}$Ca + $^{9}$Be reaction
Creators: name: Song, Y. D.
name: Wei, H. L.
name: Ma, C. W.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The cross sections for the $Z=$ 10 -- 19 with isotopes $T_{z}=-3/2$ to $-5$ in the 140$A$ MeV $^{40}$Ca + $^{9}$Be projectile fragmentation reaction have been predicted. An empirical formula based on the correlation between the cross section and average binding energy of isotope has been adopted to predict the cross section. The binding energies in the AME16, WS4, and the theoretical prediction by the spherical relativistic continuum Hartree$-$Bogoliubov theory have been used. Meanwhile, the {\sc fracs} parametrization and the modified statistical abrasion-ablation model are also used to predict the cross sections for the proton-rich isotopes. The predicted cross sections for the $T_{z}=-$3 isotopes are close to $10^{-10}$ mb, which hopefully can be studied in experiment. In addition, based on the predicted cross sections, the $Z=$ 14 is suggested to be a new magic number in the light proton-rich nuclei with $T_{z} \leq-$3/2, of which the phenomenon is much more evident than it is from the average binding energy per nucleon.
description: 4figures , 1 talbe. Accepted by Chinese Physics C
Valence extraction using EM selection and co-occurrence matrices
Creators: name: Dębowski, Łukasz
Publisher: name: arXiv
Year: 2007
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7

description: This paper discusses two new procedures for extracting verb valences from raw texts, with an application to the Polish language. The first novel technique, the EM selection algorithm, performs unsupervised disambiguation of valence frame forests, obtained by applying a non-probabilistic deep grammar parser and some post-processing to the text. The second new idea concerns filtering of incorrect frames detected in the parsed text and is motivated by an observation that verbs which take similar arguments tend to have similar frames. This phenomenon is described in terms of newly introduced co-occurrence matrices. Using co-occurrence matrices, we split filtering into two steps. The list of valid arguments is first determined for each verb, whereas the pattern according to which the arguments are combined into frames is computed in the following stage. Our best extracted dictionary reaches an $F$-score of 45%, compared to an $F$-score of 39% for the standard frame-based BHT filtering.
description: 24 pages, 3 tables
Additional file 3 of MUC1 is associated with TFF2 methylation in gastric cancer
Creators: name: Ge, Yuqiu
name: Ma, Gaoxiang
name: Liu, Hanting
name: Lin, Yadi
name: Zhang, Gang
name: Du, Mulong
name: Wang, Meilin
name: Chu, Haiyan
name: Zhang, Haiyan
name: Zhang, Zhengdong
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 3: Table S3. Correlation analysis of MUC1 methylation levels with MUC1 expression in GC tissues.
Entropy Bounds and Black Hole Remnants
Creators: name: Bekenstein, Jacob D.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We rederive the universal bound on entropy with the help of black holes while allowing for Unruh--Wald buoyancy. We consider a box full of entropy lowered towards and then dropped into a Reissner--Nordström black hole in equilibrium with thermal radiation. We avoid the approximation that the buoyant pressure varies slowly across the box, and compute the buoyant force exactly. We find, in agreement with independent investigations, that the neutral point generically lies very near the horizon. A consequence is that in the generic case, the Unruh--Wald entropy restriction is neither necessary nor sufficient for enforcement of the generalized second law. Another consequence is that generically the buoyancy makes only a negligible contribution to the energy bookeeping, so that the original entropy bound is recovered if the generalized second law is assumed to hold. The number of particle species does not figure in the entropy bound, a point that has caused some perplexity. We demonstrate by explicit calculation that, for arbitrarily large number of particle species, the bound is indeed satisfied by cavity thermal radiation in the thermodynamic regime, provided vacuum energies are included. We also show directly that thermal radiation in a cavity in $D$ dimensional space also respects the bound regardless of the value of $D$. As an application of the bound we show that it strongly restricts the information capacity of the posited black hole remnants, so that they cannot serve to resolve the information paradox.
description: 12 pages, UCSBTH-93-23
Multimode theory of Gaussian states in uniformly accelerated frames
Creators: name: Dębski, Kacper
name: Dragan, Andrzej
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We use the formalism of noisy Gaussian channels to derive explicit transformation laws describing how an arbitrary multimode Gaussian state of a scalar quantum field is perceived by a number of accelerating observers, each having access to at least one of the modes. Our work, which generalizes earlier results of Ahmadi, et al., Phys. Rev. D 93, 124031 (2016), is the next step torwards a better understanding of the effect of gravity on the states of quantum fields.
Additional file 4 of MUC1 is associated with TFF2 methylation in gastric cancer
Creators: name: Ge, Yuqiu
name: Ma, Gaoxiang
name: Liu, Hanting
name: Lin, Yadi
name: Zhang, Gang
name: Du, Mulong
name: Wang, Meilin
name: Chu, Haiyan
name: Zhang, Haiyan
name: Zhang, Zhengdong
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Additional file 4: Table S4. Multivariate cox regression analysis for survival of GC patients in TCGA database.
Power Spectrum Constraints from Spectral Distortions in the Cosmic Microwave Background
Creators: name: Hu, Wayne
name: Scott, Douglas
name: Silk, Joseph
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: %The content of this replacement paper is identical to the original. %We have attempted to fix the postscript so that it will print out on %a larger number of printers. Using recent experimental limits on $μ$ distortions from COBE FIRAS, and the large lever-arm spanning the damping of sub-Jeans scale fluctuations to the scale of the COBE DMR fluctuations, we set a constraint on the slope of the primordial power spectrum $n$. It is possible to analytically calculate the contribution over the full range of scales and redshifts, correctly taking into account fluctuation growth and damping as well as thermalization processes. We find that the 95\% upper limit is weakly dependent on cosmological parameters, e.g. $n<1.54 (h=0.5)$ and $n<1.56 (h=1.0)$ for $Ω_0=1$ with marginally weaker constraints for $Ω_0<1$ in a flat $Ω_0 +Ω_Λ=1$ universe.
description: 8pg, uuencoded-tarred (& hopefully more compatible!) postscript, CfPA-TH-94-12
Additional file 1: of Splenic vein resection together with the pancreatic parenchyma versus separated resection after isolation of the parenchyma during distal pancreatectomy (COSMOS-DP trial): study protocol for a randomised controlled trial
Creators: name: Yamada, Suguru
name: Fujii, Tsutomu
name: Kawai, Manabu
name: Shimokawa, Toshio
name: Nakamura, Masafumi
name: Murakami, Yoshiaki
name: Satoi, Sohei
name: Eguchi, Hidetoshi
name: Nagakawa, Yuichi
name: Kodera, Yasuhiro
name: Yamaue, Hiroki
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Developmental Biology

description: Institution list. (DOCX 16 kb)
The University of British Columbia Announcement of the Summer Session Eleventh Session July 2nd to August 23rd, 1930 Vancouver, British Columbia
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 11th summer session at the University of British Columbia, taking place from July 2nd to August 23rd, 1930. Contains course schedule, course descriptions and details, fees, list of students in attendance of the 1929 summer session, and other information about the session.
Enhancing radical molecular beams by skimmer cooling
Creators: name: Wu, Hao
name: Reens, David
name: Langen, Tim
name: Shagam, Yuval
name: Fontecha, Daniela
name: Ye, Jun
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: A high-intensity supersonic beam source has been a key component in studies of molecular collisions, molecule-surface interaction, chemical reactions, and precision spectroscopy. However, the molecular density available for experiments in a downstream science chamber is limited by skimmer clogging, which constrains the separation between a valve and a skimmer to at least several hundred nozzle diameters. A recent experiment (Science Advances, 2017, 3, e1602258) has introduced a new strategy to address this challenge: when a skimmer is cooled to a temperature below the freezing point of the carrier gas, skimmer clogging can be effectively suppressed. We go beyond this proof-of-principle work in several key ways. Firstly, we apply the skimmer cooling approach to discharge-produced radical and metastable beams entrained in a carrier gas. We also identify two different processes for skimmer clogging mitigation-shockwave suppression at temperatures around the carrier gas freezing point and diffusive clogging at even lower temperatures. With the carrier clogging removed, we now fully optimize the production of entrained species such as hydroxyl radicals, resulting in a gain of 30 in density over the best commercial devices. The gain arises from both clogging mitigation and favorable geometry with a much shorter valve-skimmer distance.
description: 7 pages,5 figures
Reaction coordinates for the flipping of genetic switches
Creators: name: Morelli, M. J.
name: Tanase-Nicola, S.
name: Allen, R. J.
name: Wolde, P. R. ten
Publisher: name: arXiv
Year: 2007
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: We present a detailed analysis, based on the Forward Flux Sampling (FFS) simulation method, of the switching dynamics and stability of two models of genetic toggle switches, consisting of two mutually-repressing genes encoding transcription factors (TFs); in one model (the exclusive switch), they mutually exclude each other's binding, while in the other model (general switch) the two transcription factors can bind simultaneously to the shared operator region. We assess the role of two pairs of reactions that influence the stability of these switches: TF-TF homodimerisation and TF-DNA association/dissociation. We factorise the flipping rate k into the product of the probability rho(q*) of finding the system at the dividing surface (separatrix) between the two stable states, and a kinetic prefactor R. In the case of the exclusive switch, the rate of TF-operator binding affects both rho(q*) and R, while the rate of TF dimerisation affects only R. In the case of the general switch both TF-operator binding and TF dimerisation affect k, R and rho(q*). To elucidate this, we analyse the transition state ensemble (TSE). For the exclusive switch, varying the rate of TF-operator binding can drastically change the pathway of switching, while changing the rate of dimerisation changes the switching rate without altering the mechanism. The switching pathways of the general switch are highly robust to changes in the rate constants of both TF-operator and TF-TF binding, even though these rate constants do affect the flipping rate; this feature is unique for non-equilibrium systems.
description: 24 pages, 7 figures
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0164
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0164, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0164, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The University of British Columbia Announcement of the Summer Session Twelfth Session July 2nd to August 21st, 1931 Vancouver, British Columbia
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 12th summer session at the University of British Columbia, taking place from July 2nd to August 21st, 1931. Contains course schedule, course descriptions and details, fees, list of students in attendance of the 1930 summer session, and other information about the session.
Can the Gravitational Wave Background from Inflation be Detected Locally?
Creators: name: Liddle, Andrew R
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Cosmic Background Explorer (COBE) detection of microwave background anisotropies may contain a component due to gravitational waves generated by inflation. It is shown that the gravitational waves from inflation might be seen using `beam-in-space' detectors, but not the Laser Interferometer Gravity Wave Observatory (LIGO). The central conclusion, dependent only on weak assumptions regarding the physics of inflation, is a surprising one. The larger the component of the COBE signal due to gravitational waves, the {\em smaller} the expected local gravitational wave signal.
description: 8 pages, standard LaTeX (no figures), SUSSEX-AST 93/7-3
Glucose tolerance in children and adolescents with cystic fibrosis.
Creators: name: Widger, John
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Cystic Fibrosis (CF) is the most common fatal inherited disease in Caucasians. Mean survival for this condition has increased significantly in recent decades such that extra- pulmonary complications of CF have become more apparent (1). The most important complication is abnormal glucose tolerance (AGT) as it is known to have a negative impact on important CF outcomes such as lung function and nutrition (2). Despite this, AGT in CF remains poorly understood. The overall aim of this thesis was to increase understanding of how AGT affects children and adolescents with CF. This thesis is comprised of 3 studies. The first is a cross sectional study that examined the impact of AGT on a group of children and adolescents attending the CF unit at the Royal Children’s Hospital in Melbourne. This study identified that AGT has a significantly negative impact on children and adolescents with CF including significantly worse lung function, increased admissions and infection with Pseudomonas aeruginosa. This effect was most pronounced in patients with Cystic Fibrosis Related Diabetes (CFRD) but was also present to a lesser extent in those with Impaired Glucose Tolerance (IGT). The second study examined the impact of AGT on structural lung disease in CF. In a retrospective review, spirometry and CT findings were compared in patients with Normal Glucose Tolerance (NGT), IGT and CFRD. Despite stable lung function over 2 years in all 3 groups, CT scores progressed in proportion to worsening glucose tolerance status. Finally, the impact of CF pulmonary exacerbations on glucose tolerance was studied prospectively. An oral glucose tolerance test and continuous glucose monitoring were performed during exacerbations and repeated at follow up. Contrary to a previous study, it was found that glucose tolerance status did not change significantly during exacerbations. These findings of the first two studies confirm the importance of early diagnosis and treatment of AGT in CF. Structural lung disease progressed more rapidly in patients with AGT despite stable lung function. Glucose tolerance is therefore important as it is strongly associated with progression of lung structural damage. Conventional lung function is not a surrogate for either assessing glucose status or lung structure. Finally, hyperglycaemia found during CF pulmonary exacerbations is unlikely to resolve and consideration should be given to starting those patients on insulin. Abstract references 1. Reid DW, Blizzard CL, Shugg DM, Flowers C, Cash C, Greville HM.Changes in cystic fibrosis mortality in Australia, 1979-2005. Med J Aust. 2011 Oct 3;195(7):392-5. 2. Moran A, Becker D, Casella SJ, Gottlieb PA, Kirkman MS, Marshall BC, et al. Epidemiology, pathophysiology, and prognostic implications of cystic fibrosis-related diabetes: a technical review. Diabetes Care. 2010 Dec;33(12):2677-83.
Additional file 8 of MUC1 is associated with TFF2 methylation in gastric cancer
Creators: name: Ge, Yuqiu
name: Ma, Gaoxiang
name: Liu, Hanting
name: Lin, Yadi
name: Zhang, Gang
name: Du, Mulong
name: Wang, Meilin
name: Chu, Haiyan
name: Zhang, Haiyan
name: Zhang, Zhengdong
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified

description: Additional file 8: Figure S4. A schematic representation of the 9 CpG sites located in TFF2 gene.
Additional file 1: of The prevalence of depression in axial spondyloarthritis and its association with disease activity: a systematic review and meta-analysis
Creators: name: Sizheng Zhao
name: Thong, Daniel
name: Miller, Natasha
name: Duffield, Stephen
name: Hughes, David M.
name: Chadwick, Laura
name: Goodson, Nicola
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Tables S1-S3, Figures S1-S3. (DOCX 71 kb)
NHDS: The New Hampshire Dispersion Relation Solver
Creators: name: Verscharen, Daniel
name: Chandran, Benjamin D. G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Space Physics (physics.space-ph)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: NHDS is the New Hampshire Dispersion Relation Solver. This article describes the numerics of the solver and its capabilities. The code is available for download on https://github.com/danielver02/NHDS.
description: 3 pages, 1 figure
Additional file 1: of Mild clinical features of isolated methylmalonic acidemia associated with a novel variant in the MMAA gene in two Chinese siblings
Creators: name: Yiming Lin
name: Chunmei Lin
name: Weihua Lin
name: Zhenzhu Zheng
name: Mingya Han
name: Qingliu Fu
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: Table S1. Summary of targeted gene sequencing data in the proband. (DOC 29 kb)
title: ADCO, Cart. 186 (11 H 71), f. 0196v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0196v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: UMass ADVANCE STEM Decision-Making Findings 2022
Creators: name: Liu, Shuyin
name: Misra, Joya
name: Smith-Doerr, Laurel
Publisher: name: University of Massachusetts Amherst
Year: 2023

description: Shared decision-making refers to faculty having opportunities to engage in discussions, voice their opinions, and have those opinions recognized as departments make decisions. While the university has a long history of faculty-led governance, there has always been substantial variability between departments. In addition, the pandemic has depressed opportunities for faculty to work together to make formal and informal decisions.
Tetanus in feeder calves
Creators: name: Spiece, Karen
Publisher: name: The Bovine Practitioner
Year: 1997

description: Forty-three calves out of 283 purchased and processed showed clinical signs of tetanus. Seven of those 43 died and the remaining 36 calves recovered.
description: The Bovine Practitioner, No. 31.1 (1997 January)
Pitfalls of statistics-limited X-ray polarization analysis
Creators: name: Mikhalev, Victor
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: One of the difficulties with performing polarization analysis is that the mean polarization fraction of sub-divided data sets is larger than the polarization fraction for the integrated measurement. The resulting bias is one of the properties of the generating distribution discussed in this work. The limitations of Gaussian approximations in standard analysis based on Stokes parameters for estimating polarization parameters and their uncertainties are explored by comparing with a Bayesian analysis. Different signal-to-background scenarios are considered making the analysis relevant for a large variety of observations. The effect of uncertainty on the modulation factor is also shown, since it can have a large impact on the performance of gamma-ray burst polarimeters. Results are related to the minimum detectable polarization (MDP), a common figure of merit, making them easily applicable to any X-ray polarimeter.
description: Accepted for publication in Astronomy and Astrophysics
Surface Brightness Profiles of Composite Images of Compact Galaxies at z~4-6 in the HUDF
Creators: name: Hathi, N. P.
name: Jansen, R. A.
name: Windhorst, R. A.
name: Cohen, S. H.
name: Keel, W. C.
name: Corbin, M. R.
name: Ryan, R. E.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Hubble Ultra Deep Field (HUDF) contains a significant number of B, V and i'-band dropout objects, many of which were recently confirmed to be young star-forming galaxies at z~4-6. These galaxies are too faint individually to accurately measure their radial surface brightness profiles. Their average light profiles are potentially of great interest, since they may contain clues to the time since the onset of significant galaxy assembly. We separately co-add V, i' and z'-band HUDF images of sets of z~4,5 and 6 objects, pre-selected to have nearly identical compact sizes and the roundest shapes. From these stacked images, we are able to study the averaged radial structure of these objects at much higher signal-to-noise ratio than possible for an individual faint object. Here we explore the reliability and usefulness of a stacking technique of compact objects at z~4-6 in the HUDF. Our results are: (1) image stacking provides reliable and reproducible average surface brightness profiles; (2) the shape of the average surface brightness profiles show that even the faintest z~4-6 objects are resolved; and (3) if late-type galaxies dominate the population of galaxies at z~4-6, as previous HST studies have shown, then limits to dynamical age estimates for these galaxies from their profile shapes are comparable with the SED ages obtained from the broadband colors. We also present accurate measurements of the sky-background in the HUDF and its associated 1-sigma uncertainties.
description: 10 pages, 9 figures, 2 tables, emulateapj; Accepted for publication in The Astronomical Journal
The University of British Columbia Summer Session Announcement of Courses Thirteenth Session July 4th to August 23rd, 1932 Vancouver, British Columbia
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 13th summer session at the University of British Columbia, taking place from July 4th to August 23rd, 1932. Contains course schedule, course descriptions and details, fees, and other information about the session.
Vacuum Polarization and the Electric Charge of the Positron
Creators: name: Mueller, B.
name: Thoma, M. H.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that higher-order vacuum polarization would contribute a measureable net charge to atoms, if the charges of electrons and positrons do not balance precisely. We obtain the limit $|Q_e+Q_{\bar e}| < 10^{-18} e$ for the sum of the charges of electron and positron. This also constitutes a new bound on certain violations of PCT invariance.
description: 9 pages, 1 figure attached as PostScript file, DUKE-TH-92-38. Revised version
Additional file 5 of Comparative functional genomics analysis of cytochrome P450 gene superfamily in wheat and maize
Creators: name: Li, Yixuan
name: Wei, Kaifa
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 5: Figure S3. Thirty conserved motifs of A-type P450s.
Lifting of D1-D5-P states
Creators: name: Hampton, Shaun
name: Mathur, Samir D.
name: Zadeh, Ida G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider states of the D1-D5 CFT where only the left-moving sector is excited. As we deform away from the orbifold point, some of these states will remain BPS while others can `lift'. We compute this lifting for a particular family of D1-D5-P states, at second order in the deformation off the orbifold point. We note that the maximally twisted sector of the CFT is special: the covering surface appearing in the correlator can only be genus one while for other sectors there is always a genus zero contribution. We use the results to argue that fuzzball configurations should be studied for the full class including both extremal and near-extremal states; many extremal configurations may be best seen as special limits of near extremal configurations.
description: 51 pages, 6 figures
Effective Potential of a Black Hole in Thermal Equilibrium with Quantum Fields
Creators: name: Hochberg, David
name: Kephart, Thomas W.
name: York,, James W.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Expectation values of one-loop renormalized thermal equilibrium stress-energy tensors of free conformal scalars, spin-${1 \over 2}$ fermions and U(1) gauge fields on a Schwarzschild black hole background are used as sources in the semi-classical Einstein equation. The back-reaction and new equilibrium metric are solved for at $O({\hbar})$ for each spin field. The nature of the modified black hole spacetime is revealed through calculations of the effective potential for null and timelike orbits. Significant novel features affecting the motions of both massive and massless test particles show up at lowest order in $ε= (M_{Pl}/M)^2 < 1$, where $M$ is the renormalized black hole mass, and $M_{Pl}$ is the Planck mass. Specifically, we find the tendency for \underline{stable} circular photon orbits, an increase in the black hole capture cross sections, and the existence of a gravitationally repulsive region associated with the black hole which is generated from the U(1) back-reaction. We also consider the back-reaction arising from multiple fields, which will be useful for treating a black hole in thermal equilibrium with field ensembles belonging to gauge theories.
description: 25 pages (not including seven figures), VAND-TH-93-6. Typed in Latex, uses RevTex macros
The Sodium Potassium ATPase, Caveolin 1 and their Interaction as Potential Anti-Breast Cancer Therapeutic Targets
Creators: name: Owens, Mark
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Breast cancer pathogenesis is modulated by complex signalling pathways centred on cholesterol-enriched membrane domains termed lipid rafts. Caveolae, a subtype of rafts, express the protein caveolin-1, which has been suggested as both as a tumour suppressor and promoter. One protein that interacts with caveolin-1 is the sodium potassium ATPase (Na+ K+ ATPase) ion channel. Na+ K+ ATPase has recently been implicated in cell signalling via interaction with its natural inhibitors, cardiac glycosides (CGs). Although predominantly used for heart failure indications, CGs reportedly have anti-proliferative properties in tumour cells. Given the importance of caveolin-1 in malignant behaviours, we hypothesized that CGs exert anti-breast cancer effects by modulating functional associations between Na+ K+ ATPase and caveolae. We first demonstrated concentration- and time-dependent anti-proliferative responses to the CGs digoxin, ouabain and oleandrin in breast cell lines and primary cultures. These effects were most pronounced in primary cell cultures, and least in ER/PR/HER2 triple-negative cells. We next showed concentration-dependent reductions in cell migration in response to CGs, particularly in ER-positive cells. CGs arrested the cell cycle at both G1 and S phase in ER-positive cells, with partial arrest at G1 in ER-negative cells. This was paralleled by increased p21 expression at both gene and protein level in ER-positive cells, and decreased p53 expression in ERnegative cells. CGs slightly decreased Na+ K+ ATPase association with caveolae in ER-positive cells, but increased that in ER-negative cells. Knockdown of caveolin-1 (but not the planar lipid raft marker flotillin-1) potentiated the effects of CGs in ER-negative but not ER-positive cells. Pharmacological lipid raft disruption abrogated the effects of CGs in ER-positive cells, while raft augmentation did the opposite. In contrast, raft disruption did not alter CG effects in ER-negative cells, but augmentation potentiated their effects. Finally, we showed that ouabain transiently activated both Src and ERK in ER-negative cells, but induced delayed Src and ERK activation in ER-positive cells. Taken together, our results provide novel evidence that the powerful anti-proliferative effects of CGs in breast cancer cells involve modulations of the functional association between Na+ K+ ATPase and caveolin-1. We suggest that the Na+ K+ ATPase, caveolin-1 and their interaction in caveolae represent exciting targets for consideration in future breast cancer drug development strategies.
The University of British Columbia Announcement of Courses Fourteenth Summer Session July 3rd to August 19th, 1933
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 14th summer session at the University of British Columbia, taking place from July 3rd to August 19th, 1933. Contains course schedule, course descriptions and details, fees, and other information about the session.
Dissociative electron attachment to the H2O molecule. I. Complex-valued potential-energy surfaces for the 2B1, 2A1, and 2B2 metastable states of the water anion
Creators: name: Haxton, Daniel J.
name: McCurdy, C. W.
name: Rescigno, T. N.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We present the results of calculations defining global, three-dimensional representations of the complex-valued potential-energy surfaces of the doublet B1, doublet A1, and doublet B2 metastable states of the water anion that underlie the physical process of dissociative electron attachment to water. The real part of the resonance energies is obtained from configuration-interaction calculations performed in a restricted Hilbert space, while the imaginary part of the energies (the widths) is derived from complex Kohn scattering calculations. A diabatization is performed on the 2A1 and 2B2 surfaces, due to the presence of a conical intersection between them. We discuss the implications that the shapes of the constructed potential-energy surfaces will have upon the nuclear dynamics of dissociative electron attachment to H2O. This work originally appeared as Phys Rev A 75, 012710 (2007). Typesetting errors in the published version have been corrected here.
description: Corrected version of PRA 75, 012710 (2007)
Subgroup identification in dose-finding trials via model-based recursive partitioning
Creators: name: Thomas, Marius
name: Bornkamp, Björn
name: Seibold, Heidi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: An important task in early phase drug development is to identify patients, which respond better or worse to an experimental treatment. While a variety of different subgroup identification methods have been developed for the situation of trials that study an experimental treatment and control, much less work has been done in the situation when patients are randomized to different dose groups. In this article we propose new strategies to perform subgroup analyses in dose-finding trials and discuss the challenges, which arise in this new setting. We consider model-based recursive partitioning, which has recently been applied to subgroup identification in two arm trials, as a promising method to tackle these challenges and assess its viability using a real trial example and simulations. Our results show that model-based recursive partitioning can be used to identify subgroups of patients with different dose-response curves and improves estimation of treatment effects and minimum effective doses, when heterogeneity among patients is present.
description: 23 pages, 6 figures
Additional file 2: of Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma
Creators: name: Iyer, Priyanka
name: Dadu, Ramona
name: Gule-Monroe, Maria
name: Naifa Busaidy
name: Ferrarotto, Renata
name: Habra, Mouhammed
name: Zafereo, Mark
name: Williams, Michelle
name: G. Gunn
name: Horiana Grosu
name: Skinner, Heath
name: Sturgis, Erich
name: Gross, Neil
name: Cabanillas, Maria
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology

description: Figure S1. Patient number 10 who had a PR with a tumor regression of 47% on the combination of pembrolizumab and lenvatinib continues to have a response at the time of data analysis. Axial post contrast CT images through the chest demonstrates right lower lobe pulmonary nodule (red arrow) and pleural based left lower lobe nodularity (yellow arrow) on baseline scan(A) with treatment response on subsequent follow up imaging at 5Â months (B) and 8Â months (C). (PDF 256 kb)