cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A method for generating a controllable and quasi time optimal robot trajectory.
Creators: name: Amara, Sofian.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Mechanical.

description: Robot arms are used within their wok space to execute a variety of physical tasks like pick and place, or weld along a contour. From a robot control perspective, these tasks can be simply viewed as tasks of trajectory planning of the robot end effector. The path of the robot end effector is generally prescribed as a number of spatial points through which the end effector has to pass. A large number of approaches for the planning of the trajectory of a robot has been developed. These approaches do not generally allow adequate control over the acceleration profile of the trajectory. Furthermore, among those approaches only a few generate trajectories that are time optimal, and only for very simplistic robots. This work deals with yet another method for trajectory planning. The method allows full control over the acceleration profile so as to minimize the jerk at the beginning and end of the motion. The method also allows the utilization of the axes drive motors to their full capability in order to obtain a quasi-optimum trajectory that passes through all the points defining the end effector path. Simulation of the method for a three degrees of freedom revolute arm manipulator has been carried out. Results and discussion are presented in this study.
title: Drinking patterns at the sub-national level
title: What do they tell us about drinking cultures in European countries?
titleType: Subtitle
Creators: name: Bloomfield, Kim
name: Grittner, Ulrike
name: Kraus, Ludwig
name: Piontek, Daniela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: drinking culture
subject: drinking patterns
subject: geography
subject: Denmark
subject: Germany
subject: regions
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Aim: A drinking pattern is not only a major drinking variable, but is also one indicator of a country’s drinking culture. In the present study, we examine drinking patterns within and across the neighbouring countries of Denmark and Germany. The aim of the research is to determine to what extent drinking patterns differ or are shared at the sub-national level in the two countries. Method: Data came from the German 2012 Epidemiological Survey of Substance Use (n = 9084) 18–64 years (response rate 54%), and the Centre for Alcohol and Drug Research’s 2011 Danish national survey (n = 5133) 15–79 years (response rate 64%), which was reduced to a common age range, producing a final n = 4016. The drinking pattern variable included abstention, moderate drinking, heavy drinking, risky single occasion drinking (RSOD), and was investigated with bivariate statistics and gender-specific hierarchical cluster analysis. Results: For men three clusters emerged: one highlighting abstention and RSOD, moderate/heavy drinking, RSOD and RSOD + heavy drinking. For women, two clusters appeared: one highlighting abstention and moderate/heavy drinking and the other highlighting RSOD and RSDO + heavy drinking. The clusters revealed different geographical patterning: for men, a west vs. east divide; for women, a north–south gradient. Conclusions: The analysis could identify for each gender clusters representing both separate and shared drinking patterns as well as distinctive geographical placements. This new knowledge can contribute to a new understanding of the dynamics of drinking cultures and could indicate new approaches to prevention efforts and policy initiatives.
Immigrant parent experiences of receiving their child's psychoeducational diagnosis : informing school psychologists' practice
Creators: name: Nasseri, Anisa
Publisher: name: University of British Columbia
Year: 2025

description: In this study the researcher sought to investigate the experiences of immigrant parents upon finding out their child’s diagnosis within the psychoeducational feedback meeting. Once a psychoeducational assessment is complete, the student’s parents participate in a feedback meeting with the assessing psychologist where the assessment results, including any diagnosis, is communicated. These meetings can be emotional, challenging, and meaningful to families. How the psychologist communicates the results of an assessment can directly impact parents understanding of the assessment results and their child’s needs, which consequently impacts the child’s access to supports. Although a small body of existing research examines the characteristics of successful feedback meetings, little research has been done on the experience of immigrant families in these feedback sessions. Immigrants may face challenges when accessing care and communicating with professionals due to structural barriers and linguistic and cultural differences. Thus, in the present study, 10 immigrant parents whose child had undergone a psychoeducational assessment in Canada were interviewed. The lived experiences of these participants within the feedback meeting and upon hearing news of their child’s diagnosis were explored using interpretative phenomenological analysis. Five group-level superordinate themes and 19 subordinate themes emerged from the data. The group-level themes included Positive Experiences, Challenges and Doubts, Impact of Culture and Language, Emotional Reactions, and Journey Beyond the Feedback Meeting. Through highlighting the voices of immigrant parents, implications for school psychologists’ practice are explored in order to offer suggestions for improving communication and service provision for immigrant families in the feedback meeting.
Spread spectrum fiber LANs.
Creators: name: Khaleghi, Farideh.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Electronics and Electrical.

description: In this thesis, a hybrid scheme is proposed for the purpose of suppressing the effect of external modulation and/or laser nonlinearities in Subcarrier Multiplexing (SCM) fiber optic communications systems. Hybrid CDMA/FDMA combines two schemes in such a way that the resulting hybrid network is robust against interference and is much more spectrally efficient than a CDMA system. Several possible architectures for the hybrid CDMA/FDMA subcarrier fiber optic Local Area Network (LAN) are introduced. These networks utilize CDMA and SCM, an asynchronous multiple access scheme with no waiting time. Direct Sequence Spread Spectrum Multiple Access (DS/SSMA), the most common form of CDMA in which each user is assigned a particular code sequence which modulates the carrier along with digital data, is employed. It is shown that by using the code sequence sets for which the shift-and-add property holds, the Intermodulation Products (IMPs) and harmonics have a similar interference-like effect as the non-matching sequences. Owing to the fact that shift-and-add property holds for conventional spreading sequences, i.e., Gold, Kasami and maximal-length sequences, the suppression of nonlinearity distortion is evaluated. An average error probability performance evalution of the selected configuration for a transceiver pair is presented. In analysis of the system, we assume the interference term arising from other users is gaussian distributed. The results are compared to that obtained from exact evaluation of interference distribution using the Gauss Quadrature Rule integration (GQR) method. We compare the performance of this scheme for two different code sequence sets (N = 127 Gold and N = 255 Kasami codes) and determine that there is a significant advantage in deploying the N = 255 Kasami codes. We also present some preliminary experimental results on the proposed LAN implementation as well as the transmission performance. The results show great promise.
title: Development of a test method for transformation of veterinary pharmaceuticals and biocides in anaerobic liquid manure
title: Development of a test method for transformation of veterinary pharmaceuticals and biocides in anaerobic liquid manure
titleType: AlternativeTitle
Creators: name: Junker, Thomas
name: Atorf, Cornelia
name: Berkner, Silvia
name: Konradi, Sabine
Publisher: name: My University
Year: 2020
Subjects: Dung
Tierarzneimittel
Arzneimittel
Biozid
Abbau

description: Background Spreading of manure on agricultural soils represents an important pathway by which veterinary medicinal and biocidal products enter the environment. To assess their environmental impact in the context of authorization processes, experimental testing of transformation of these compounds in manure is considered in regulatory guidance documents. However, there is no standardized experimental test method available so far. To fill this gap, an experimental test method was developed to examine transformation in liquid cattle and pig manure. Results To account for manure specifics and for a possible influence of manure parameters on transformation rates, a comprehensive data acquisition and statistical analysis were performed. To address the variability of liquid manure of different type and origin, 30 manures were sampled and characterized. Thereof, three cattle and three pig manures were selected to perform anaerobic transformation studies with two radiolabeled veterinary medicinal active substances (14C-salicylic acid and 14C-paracetamol) and a confidential radiolabeled "14C-biocide B" serving as test compounds. Spatial and seasonal variability of manure parameters was quantified, and a sampling technique to obtain homogenous manure samples was developed. Transformation studies with six replicates per sampling point were conducted to examine the influence of test setup, of manure storage conditions, and of parameter variations between manure of the same species and of different species on half-lives, formation of extractable and non-extractable residues and mineralization rates. Finally, a test design was established that yields reproducible results for transformation studies in liquid cattle and pig manure under anaerobic conditions. Conclusions Results give a reliable basis for an experimental test method to perform anaerobic transformation studies in liquid cattle and pig manure. The developed test method comprises detailed guidance on selection of sampling date and site, collection from manure tank, storage duration and temperature in the laboratory, duration of manure acclimation period, and the incubation system design. It proved to give reproducible results in a validation ring test performed in a follow-up project and is planned to be submitted as draft test guideline for approval by the OECD. © The Author(s) 2020.
A molecular dynamics study of the energy of activation of a vacancy in an ideal xenon monolayer and a monolayer of xenon adsorbed on silver(111).
Creators: name: Barka, Baghdad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Physics, Molecular.

description: We present a molecular dynamics study of the activation energy of a vacancy in a monolayer of xenon with two and three degrees of freedom, in the latter case in the presence of a Ag(111) substrate. The large activation energy decreases with the third degree of freedom. The minimum energy trajectory between two lattice positions is given. In the three dimensional case the activated atom dips while the neighboring atoms rise. With temperature the activation energy increases by about 10 percent from 5 to 65K in both the two dimensional and three dimensional cases. The interaction between two vacancies has been investigated. This interaction is attractive, long-range and strong, similar in depth to the interparticle interaction.
Forum "Fischschutz und Fischabstieg"
Creators: name: Kampa, Eleftheria
name: Stein, Ulf
Publisher: name: My University
Year: 2015
Subjects: subject: Energienutzung
subject: Fischtreppe
subject: Ökologische Durchgängigkeit
subject: Biologische Vielfalt
subject: Erneuerbare Energie
subject: Nutzung der Wasserkraft
subject: Biodiversität
subject: Fischpopulation
subject: Flüsse
subject: Klima | Energie
subject: Wasser
subject: Climate | Energy
subject: Water

description: Das Thema Fischschutz und Fischabstieg wird unter fachlichen und umweltpolitischen Gesichtspunkten zwischen und innerhalb der einzelnen Fachdisziplinen und Zuständigkeiten intensiv bis kontrovers diskutiert. Dies war für das Umweltbundesamt Veranlassung, unterstützt von Ecologic Institut, ein „Forum Fischschutz und Fischabstieg“ einzurichten. Im Forum engagieren sich seit 2012 über 200 Personen Interessen übergreifend aus allen relevanten Sektoren. Im Ergebnis des intensiv geführten und weiter zu führenden Diskussionsprozesses konnte zu zahlreichen Punkten ein gemeinsames Verständnis darüber erarbeitet werden, welche Anforderungen und Lösungen nach dem derzeitigen Stand des Wissens und der Technik dem Fischschutz und Fischabstieg und dem Erhalt und der Etablierung von Fischpopulationen zu Grunde gelegt werden können. Es wird ebenso deutlich, welche unterschiedlichen Wertvorstellungen Ausdruck in Positionen finden. Das vorliegende Synthesepapier ist Ausdruck der geführten Diskussion in den Workshops des Forums.
Supplementary document for Dissipative cnoidal waves (Turing rolls) and the soliton limit in microring resonators - 3945838.pdf
Creators: name: Qi, Zhen
name: Wang, Shaokang
name: Jaramillo-Villegas, Jose
name: Qi, Minghao
name: Weiner, Andrew
name: D'Aguanno, Giuseppe
name: Carruthers, Thomas
name: Menyuk, Curtis
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Nonlinear Optics and Spectroscopy

description: Supplement 1
Supplementary document for Dissipative cnoidal waves (Turing rolls) and the soliton limit in microring resonators - 3945838.pdf
Creators: name: Qi, Zhen
name: Wang, Shaokang
name: Jaramillo-Villegas, Jose
name: Qi, Minghao
name: Weiner, Andrew
name: D'Aguanno, Giuseppe
name: Carruthers, Thomas
name: Menyuk, Curtis
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Nonlinear Optics and Spectroscopy

description: Supplement 1
Aktualisierung und methodische Überarbeitung des Nationalen Wohlfahrtsindex 2.0 für Deutschland - 1991 bis 2012
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Nationaler Wohlfahrtsindex
subject: Nachhaltige Entwicklung
subject: alternative Wohlfahrtsmessung
subject: Indikatoren
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: Die Studie gibt zunächst einen Überblick über die aktuelle Diskussion um die Messung von Wachstum und Wohlfahrt und zur Kritik an der Eignung des Bruttoinlandsprodukts als Wohlfahrtsmaß. Danach wird die Entwicklung der Methodik des Nationalen Wohlfahrtsindex (NWI) seit 2009 geschildert und die Resonanz, die dieses Wohlfahrtsmaß in der Wissenschaft, der Politik und der Öffentlichkeit gefunden hat. Der Hauptteil der Arbeit bezieht sich dann auf die Aktualisierung der Zeitreihe des NWI bis 2012, was eine ausführliche Diskussion der zwanzig Komponenten des NWI mit einschließt. Die aktuelle Entwicklung des NWI wird sodann ausführlich diskutiert, der Einfluss der einzelnen Komponenten wird abgeschätzt. Schließlich werden methodologische Verbesserungen in der Aktualisierung detailliert beschrieben und Vorüberlegungen zu weiteren methodischen Verbesserungen präsentiert. Die Arbeit schließt mit einem Fazit zur Einschätzung einer möglichen Etablierung des NWI als alternativem Wohlfahrtsmaß.Quelle: https://www.umweltbundesamt.de
description: Die Studie gibt zunächst einen Überblick über die aktuelle Diskussion um die Messung von Wachstum und Wohlfahrt und zur Kritik an der Eignung des Bruttoinlandsprodukts als Wohlfahrtsmaß. Danach wird die Entwicklung der Methodik des Nationalen Wohlfahrtsindex (NWI) seit 2009 geschildert und die Resonanz, die dieses Wohlfahrtsmaß in der Wissenschaft, der Politik und der Öffentlichkeit gefunden hat. Der Hauptteil der Arbeit bezieht sich dann auf die Aktualisierung der Zeitreihe des NWI bis 2012, was eine ausführliche Diskussion der zwanzig Komponenten des NWI mit einschließt. Die aktuelle Entwicklung des NWI wird sodann ausführlich diskutiert, der Einfluss der einzelnen Komponenten wird abgeschätzt. Schließlich werden methodologische Verbesserungen in der Aktualisierung detailliert beschrieben und Vorüberlegungen zu weiteren methodischen Verbesserungen präsentiert. Die Arbeit schließt mit einem Fazit zur Einschätzung einer möglichen Etablierung des NWI als alternativem Wohlfahrtsmaß.
Fracture resistance of defective amalgam restorations repaired with a resin based-composite material
Creators: name: Hopkins, Catherine Eva
Publisher: name: University of Iowa
Year: 2024
Subjects: public abstract

description: Repair is a minimally invasive approach used to increase the longevity of existing defective restorations, such as large amalgams. The aim of this study was to investigate the fracture resistance and fracture modes of mesio-occlusal-distal (MOD) amalgam molar restorations with extensive cuspal fracture repaired or replaced using a bulk-fill resin-based composite material (BFC).Methods: Amalgam restorations were placed in 84 permanent molars and randomly assigned to six groups (n=14): 1- MOD amalgam (control), 2-Composite repair of one-cusp fracture + the adjacent proximal box, 3-Composite repair of one-cusp fracture, 4- Composite repair of two-cusp fracture, 5-Replacement of one-cusp defect and existing MOD amalgam, 6- Replacement of two-cusp defect and MOD amalgam. Each molar was prepared to simulate the fracture, stored in distilled water for at 37°C for 7-10 days, and restored according to the groups above. Specimens were then submitted to cyclic-loading for 500,000 cycles in distilled water ay 37°C and then loaded to fracture using a universal testing machine at a crosshead speed of 1mm/min. Force at fracture and fracture modes were recorded. Fracture modes were categorized as: A- composite OR amalgam fractured, B-composite and/or amalgam and/or tooth structure fractured, C- specimen fractured beyond reparable measures deeming the tooth non-restorable.
description: Results: ANOVA followed by Tukey tests showed significant differences (p<.001) between Group 4 (1652.3N) and each of groups 5 (3095.0N), 1 (2669.8N), 6 (2658.6N), and 2 (2442.9N), as well as between group 3 (2133.5N) and group 5 (3095.0N). Fisher’s exact test demonstrated (p<.001) that Group 1 fractures by mostly mode B and C, Groups 2, 3, and 4 fractured by mode B. Group 5 was mostly modes A and C, while group 6 had the majority come from mode C. Specimens that fractured at mode C all had higher force on average.
description: Conclusions: Within the limitations of this study, the repair of cusp fractures in existing MOD amalgam-restored molars is a viable option rather than replacing existing restorations entirely; however, replacement of the defect and the existing restoration with a resin-based composite material will withstand higher forces.
Prognostic significance of macrophage invasion in hilar cholangiocarcinoma
Creators: name: Atanasov, Georgi
name: Hau, Hans-Michael
name: Dietel, Corinna
name: Benzing, Christian
name: Krenzien, Felix
name: Brandl, Andreas
name: Wiltberger, Georg
name: Matia, Ivan
name: Prager, Isabel
name: Schierle, Katrin
name: Robson, Simon C.
name: Reutzel-Selke, Anja
name: Pratschke, Johann
name: Schmelzle, Moritz
name: Jonas, Sven
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Hilar cholangiocarcinoma
subject: Tumor associated macrophages
subject: TAMs
subject: CD68
subject: Liver resection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Tumor-associated macrophages (TAMs) promote tumor progression and have an effect on survival in human cancer. However, little is known regarding their influence on tumor progression and prognosis in human hilar cholangiocarcinoma. Methods We analyzed surgically resected tumor specimens of hilar cholangiocarcinoma (n = 47) for distribution and localization of TAMs, as defined by expression of CD68. Abundance of TAMs was correlated with clinicopathologic characteristics, tumor recurrence and patients’ survival. Statistical analysis was performed using SPSS software. Results Patients with high density of TAMs in tumor invasive front (TIF) showed significantly higher local and overall tumor recurrence (both ρ
Ambition lohnt sich: Wir brauchen ehrgeizige Bekenntnisse zum Klimaschutz
Creators: name: Burger, Andreas
name: Lünenbürger, Benjamin
Publisher: name: My University
Year: 2014
Subjects: subject: Internationale Klimapolitik
subject: Internationale Klimaschutzpolitik
subject: Internationaler Klimaschutz
subject: Klimaschutzabkommen
subject: Klima | Energie
subject: Climate | Energy

description: Gegen den Klimawandel müssen unverzüglich Maßnahmen zur Minderung von Treibhausgasen ergriffen werden. Frühzeitig und ambitioniert zu handeln ist auch ökonomisch sinnvoll. Denn je später wir mit dem Klimaschutz beginnen, umso teurer wird er. Außerdem birgt eine Transformation hin zu einer kohlenstoffarmen Wirtschaft, insbesondere der Ausbau der erneuerbaren Energien und die Steigerung der Energieeffizienz, auch wirtschaftliche Chancen. Klimaschutz schafft Wachstum und Beschäftigung. Dies zeigt sich für Deutschland und weltweit. Am 23. September 2014 kommen die Staats- und Regierungschefs zu einem UN-Sondergipfel in New York zusammen. Hier gilt es, die bisher zugesagten Minderungsanstrengungen bis 2020 zu erhöhen und mit ambitionierten Zusagen für eine neue Klimaschutzvereinbarung ab 2020 ein glaubwürdiges Zeichen für den globalen Klimaschutz zu setzen.
Quelle: Verlagsinformation
description: Gegen den ⁠Klimawandel⁠ müssen unverzüglich Maßnahmen zur Minderung von Treibhausgasen ergriffen werden. Frühzeitig und ambitioniert zu handeln ist auch ökonomisch sinnvoll. Denn je später wir mit dem ⁠Klimaschutz⁠ beginnen, umso teurer wird er. Außerdem birgt eine Transformation hin zu einer kohlenstoffarmen Wirtschaft, insbesondere der Ausbau der erneuerbaren Energien und die Steigerung der Energieeffizienz, auch wirtschaftliche Chancen. Klimaschutz schafft Wachstum und Beschäftigung. Dies zeigt sich für Deutschland und weltweit. Am 23. September 2014 kommen die Staats- und Regierungschefs zu einem ⁠UN⁠-Sondergipfel in New York zusammen. Hier gilt es, die bisher zugesagten Minderungsanstrengungen bis 2020 zu erhöhen und mit ambitionierten Zusagen für eine neue Klimaschutzvereinbarung ab 2020 ein glaubwürdiges Zeichen für den globalen Klimaschutz zu setzen.
Simulating articular fracture reduction for surgical training
Creators: name: Tatum, Marcus
Publisher: name: University of Iowa
Year: 2019
Subjects: Articular Fracture Reduction Simulation
Simulator
Surgical Simulation
Surgical Simulator

description: Repairing articular fractures is a complex and challenging task that demands competency in both physical and cognitive skills. Currently, there are few methods for novice surgeons to hone the skills necessary for articular fracture reduction outside of the operating room. The need for a standalone training platform has become more urgent to meet new mandates requiring dedicated skills training during the first year of orthopaedic residency. To address this, this research team has created a set of novel fracture reduction simulators.
description: Much of this work describes the development of these fracture reduction simulators. These simulators combine physical fracture models and surgical tools with virtually generated, radiation free imaging to recreate fracture reduction surgeries in a safe and repeatable environment, conducive to learner advancement.
description: As a validation study, performances between novice (n=6) and experienced (n=4) surgeons were assessed to determine whether the simulators can accurately differentiate skill levels. This assessment involved using a tenaculum to reduce a simulated partial articular fracture of the distal tibia. This results of this study showed that expert surgeons significantly outperformed the novice cohort in the time it took to complete the reduction (average 61.4 seconds vs. 151.2 seconds, p = 0.012), the number of images they used (average 6.6 vs. 16.3, p = 0.012), the cumulative distance the fracture fragment was manipulated (average 36.6 mm vs. 132.4 mm, p = 0.3), the amount of contact points between the surgical tools and the fragments (average 8.25 vs. 23.7, p = 0.03), and the number of discrete attempts to achieve the final reduction (average 1.25 vs. 6.5, p = 0.03). The results of this study show that these simulators can successfully differentiate skill levels between novice and advanced users and indicates the potential for further development of the systems into full training platforms to compliment the traditional education system.
Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6
Creators: name: Greninger, Alexander L
name: Knudsen, Giselle M
name: Roychoudhury, Pavitra
name: Hanson, Derek J
name: Sedlak, Ruth H
name: Xie, Hong
name: Guan, Jon
name: Nguyen, Thuy
name: Peddu, Vikas
name: Boeckh, Michael
name: Huang, Meei-Li
name: Cook, Linda
name: Depledge, Daniel P
name: Zerr, Danielle M
name: Koelle, David M
name: Gantt, Soren
name: Yoshikawa, Tetsushi
name: Caserta, Mary
name: Hill, Joshua A
name: Jerome, Keith R
Publisher: name: BioMed Central
Year: 2018

description: Background: Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomally integrated HHV-6 (iciHHV-6). Only two complete genomes are available for replicating HHV-6B, leading to numerous conflicting annotations and little known about the global genomic diversity of this ubiquitous virus. Results: Using a custom capture panel for HHV-6B, we report complete genomes from 61 isolates of HHV-6B from active infections (20 from Japan, 35 from New York state, and 6 from Uganda), and 64 strains of iciHHV-6B (mostly from North America). HHV-6B sequence clustered by geography and illustrated extensive recombination. Multiple iciHHV-6B sequences from unrelated individuals across the United States were found to be completely identical, consistent with a founder effect. Several iciHHV-6B strains clustered with strains from recent active pediatric infection. Combining our genomic analysis with the first RNA-Seq and shotgun proteomics studies of HHV-6B, we completely reannotated the HHV-6B genome, altering annotations for more than 10% of existing genes, with multiple instances of novel splicing and genes that hitherto had gone unannotated. Conclusion: Our results are consistent with a model of intermittent de novo integration of HHV-6B into host germline cells during active infection with a large contribution of founder effect in iciHHV-6B. Our data provide a significant advance in the genomic annotation of HHV-6B, which will contribute to the detection, diversity, and control of this virus.
Oral Escherichia coli expressing IL-35 meliorates experimental colitis in mice
Creators: name: Zhang, Baoren
name: Liu, Yi
name: Lan, Xu
name: Xu, Xiaoxi
name: Zhang, Xiaoning
name: Li, Xiang
name: Zhao, Yiming
name: Li, Guang
name: Du, Caigan
name: Lu, Shanzheng
name: Wang, Hao
Publisher: name: BioMed Central
Year: 2018

description: Background: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation of colon. It is commonly believed that the imbalance of immune system and overwhelming production of cytokines are involved in the pathogenesis of UC. Recent studies demonstrated that interleukin-35 (IL-35), a key player in the regulation of inflammation, has been identified as potential therapeutic target to treat UC. However, conventional intravenous administration is costly and inconvenient. The present study was designed to establish a novel IL-35 delivery system and investigate its therapeutic effects on dextran sulfate sodium (DSS)-induced experimental colitis in mice for the first time. Methods: An engineered Escherichia coli (E. coli/IL-35) expressing IL-35 was constructed. Adult male BALB/c mice randomly got the oral administration of E. coli/IL-35, empty plasmid-transformed E. coli (E. coli0) or PBS for treatment following ingestion of 3% DSS solution for 5 days. Normal mice were used as control group. Colonic and splenic tissues were collected on day 10 post-DSS-induction. Clinical signs, disease activity index (DAI), pathological and immunohistological changes, cytokine profiles and cell populations were evaluated. Results: Intragastric administration of E. coli/IL-35 effectively protected the colitis mice from DSS assimilation including weight loss and colon shortening. Pathological analysis showed significantly lower DAI score and much less intra-colon infiltration of neutrophils and CD3+ cells in the IL-35 treated group. Moreover, E. coli/IL-35-treated mice demonstrated much less CD4+ IL-17A+ Th17 cells and a higher level of CD4+CD25+Foxp3+ Tregs in spleen and mesenteric lymph nodes, as well as increased colon and serum level of IL-10 and IL-35 and decreased levels of IL-6. Conclusions: Our study showed that E. coli/IL-35 as a novel oral IL-35 delivery system alleviated inflammatory damage of colonic tissue in the colitic mice. Genetic therapeutic strategies using engineered E. coli encoding immunoregulatory cytokines may provide a potential approach for the treatment of IBD.
Housing Design Innovations Delivered Under the National Social Housing Initiative
Creators: name: Murray, Shane
name: Bertram, Nigel
name: Khor, Lee-anne
name: Meyer, Byron
name: Rowe, Deborah
name: Murphy, Catherine
name: Newton, Peter
name: Glackin, Stephen
name: Alves, Tom
name: Mcgauran, Rob
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 3304
subject: Urban and regional planning

description: The Social Housing Initiative (SHI) formed part of the federal government's response to the Global Financial Crisis and represented the largest one-time investment in social housing by any government in Australia's history. This paper examines the built results of the SHI, with the analysis focused on housing design and procurement outcomes. Public housing redevelopment is an opportunity for innovation and market leadership in affordable housing design and delivery. While the SHI's primary objective was to provide jobs in the construction industry at a time of potential economic crisis, this paper reveals that good quality innovative housing outcomes were achieved. However these were more a chance by-product of the process rather than a strategic intention. The vast majority of projects delivered in Melbourne, for instance, were 'business as usual' 2-for-1 dual occupancy developments. Given the magnitude of the SHI building program, this outcome can be considered a lost opportunity and an underutilisation of public investment (financial and land). This paper provides a survey of individual developments that did show innovation, illustrating through spatial analysis how quality housing and urban outcomes can be achieved within constrained social housing scenarios. The design innovations were often simple but well executed strategies, focusing on efficiency of internal apartment/unit planning, arrangement of tenancy mix/social diversity, interfaces of private dwellings with common areas and public spaces, parking arrangements, design of common areas, and addressing privacy and noise through landscaping and careful planning. The paper also describes the critical role that procurement methods play, particularly creative/nonstandard approaches to partnerships and financing, in delivering innovative design outcomes. Factors leading to innovation included the involvement of Community Housing Organisations who could access alternative land and funding sources, offer design and delivery expertise and facilitate mixed tenancy outcomes, alongside the relaxation of selected planning controls, and project alignment with existing urban renewal strategies.
Interactive video-based technology and perceptual skill training for batting in youth baseball players
Creators: name: Manalo, Gabriel Noah
Publisher: name: University of British Columbia
Year: 2025

description: The pursuit of a competitive advantage in sports has increasingly emphasized the development of perceptual-cognitive skills, which underlie anticipation and decision-making in interceptive sports like baseball. This cross-sectional pilot study aimed to assess the effects of a baseball-specific perceptual-cognitive training video game as an adjunct tool to traditional batting practice. Twenty male youth athletes (ages 13– 17) with at least one year of competitive baseball experience as batting athletes, were quasi-randomly assigned to either an intervention group (n = 10) or a control group (n = 10). All athletes engaged in 90 minutes of a typical batting program on each of seven training days. The intervention group engaged in a batting-specific video game during rest intervals, while the control group received typical rest periods. Player performance was assessed at pre-test, at immediate post-test, and at delayed retention (one week after training). Outcome measures included a 15-pitch live batting scenario, a pitch-type and location anticipation task, and a coincident anticipation timing task. The final analysis included 13 participants (n = 7 control; n = 6 intervention). A significant main effect of Time was observed for coincident anticipation timing (both absolute error, F(1.32, 14.46) = 10.74, p = .003 and constant error, F(1.36, 14.91) = 6.33, p = .017) and for pitch type recognition in the occlusion task, F(2, 22) = 8.09, p = .002. In the live batting task, a significant main effect of Group was found, where the intervention group demonstrated superior decision accuracy, F(1, 11) = 9.54, p = .010, and chase rate performance, F(1, 11) = 6.54, p = .027, compared to the control group at retention. These findings support the integration of a baseball-specific perceptual-cognitive video game as a supplement to traditional baseball practice. From a practical perspective, these findings also show that rest intervals during physical practice can be optimized to develop perceptual-cognitive skills. Future research should explore optimal duration and scheduling of video-based perceptual-cognitive training, assess transferability to real-game performance, examine differences across age and skill levels, and compare outcomes across diverse sport skills and digital technology.
Women's magazines and the representation of death in eighteenth-century England.
Creators: name: Whiting, Patricia A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Women's Studies.

description: This thesis argues that women's magazines in eighteenth-century England were not, as some recent scholarship has maintained, primarily instruments of gender construction. Rather, for the first seventy years of the century, periodicals directed at a mainly female readership represented a significant attempt to configure women's roles more actively within the emergent social order. Taking death as a subject, the thesis investigates the representation of death in the magazines, in order to show the ways in which they articulated and participated in the major discourses of the period, sometimes from a female perspective, and to show the ways in which the interests of women readers intersected with those of men in ways that were not always inflected by gender. The first part of the thesis is a summary account of print culture in the eighteenth century, especially with regard to the relationships between the new periodical press and the desire of eighteenth-century readers for improvement. Particular emphasis is given to this relationship in terms of women readers. The second, longer part of the thesis is an investigation into the representation of death in eighteenth-century women's magazines. This part relies extensively on primary material from the magazines and examines death in terms of changing attitudes and practices, in terms of the ways it was experienced in eighteenth-century life and reported in the magazines, and in terms of the suicide debate, a major eighteenth-century discourse that was intricately bound up with other issues of concern to the emergent middle classes.
Good Manufacturing Practice-Compliant Production and Lot-Release of Ex Vivo Expanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders
Creators: name: Wiesinger, Manuel
name: Stoica, Diane
name: Roessner, Susanne
name: Lorenz, Carmen
name: Fischer, Anika
name: Atreya, Raja
name: Neufert, Clemens F.
name: Atreya, Imke
name: Scheffold, Alexander
name: Schuler-Thurner, Beatrice
name: Neurath, Markus F.
name: Schuler, Gerold
name: Voskens, Caroline J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: regulatory T cell
subject: good manufacturing practice
subject: autoimmunity
subject: expansion
subject: lot-release
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In recent years, the exploration of regulatory T cell (Treg)-based cellular therapy has become an attractive strategy to ameliorate inflammation and autoimmunity in various clinical settings. The main obstacle to the clinical application of Treg in human is their low number circulating in peripheral blood. Therefore, ex vivo expansion is inevitable. Moreover, isolation of Treg bears the risk of concurrent isolation of unwanted effector cells, which may trigger or deteriorate inflammation upon adoptive Treg transfer. Here, we present a protocol for the GMP-compliant production, lot-release and validation of ex vivo expanded Tregs for treatment of patients with autoimmune and inflammatory disorders. In the presented production protocol, large numbers of Treg, previously enriched from a leukapheresis product by using the CliniMACS® system, are ex vivo expanded in the presence of anti-CD3/anti-CD28 expander beads, exogenous IL-2 and rapamycin during 21 days. The expanded Treg drug product passed predefined lot-release criteria. These criteria include (i) sterility testing, (ii) assessment of Treg phenotype, (iii) assessment of non-Treg cellular impurities, (iv) confirmation of successful anti-CD3/anti- CD28 expander bead removal after expansion, and (v) confirmation of the biological function of the Treg product. Furthermore, the Treg drug product was shown to retain its stability and suppressive function for at least 1 year after freezing and thawing. Also, dilution of the Treg drug product in 0.9% physiological saline did not affect Treg phenotype and Treg function for up to 90 min. These data indicate that these cells are ready to use in a clinical setting in which a cell infusion time of up to 90 min can be expected. The presented production process has recently undergone on site GMP-conform evaluation and received GMP certification from the Bavarian authorities in Germany. This protocol can now be used for Treg-based therapy of various inflammatory and autoimmune disorders.
La mise en forme de l'affaire Belmoral : une étude de cas.
Creators: name: Cyr Haythornthwaite, Caroline.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Sociology, Criminology and Penology.

description: Cette recherche de type qualitatif a pour objet d'étude le fonctionnement d'une commission d'enquête publique. Plus particulièrement, elle se penche sur l'étude de cas de l'affaire Belmoral. Suite à l'effondrement de la mine Belmoral, le 20 mai 1980, à Val d'Or, une commission d'enquête fut instituée pour enquêter sur les événements entourant cet effondrement. Se basant sur l'analyse de contenu des notes sténographiques et du rapport final de l'enquête, de mémé que sur les récits de presse, cette recherche vise à exposer la reconstruction que la Commission a faite des événements entourant l'effondrement, menant vers la mise en forme de l'affaire Belmoral. Bref, cette recherche nous a permis d'illustrer les diverses fonctions et contraintes gérant une commission d'enquête publique. Et, plus que tout, elle nous a permis de démontrer l'utilité incontestable de l'enquête publique, utilité qui souvent, à première vue, peut sembler symbolique. (Abstract shortened by UMI.)
title: Tromboembolismo pulmonar: optimización del protocolo de angioTC con bajo kilovoltaje y baja dosis de contraste
Creators: name: Viteri, Guillermo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT-Angiography
subject: Pulmonary vessels
subject: Thorax

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar los protocolos de angiografía pulmonar por TCMD para el diagnostico de tromboembolismo pulmonar,
así como las principales estrategias de optimización...
Precinct regeneration of dispersed public housing in middle suburbs
Creators: name: Bertram, Nigel
name: Murray, Shane
name: Khor, Lee-anne
name: Meyer, Byron
name: Rowe, Deborah
name: Murphy, Catherine
name: Newton, Peter
name: Glackin, Stephen
name: Alves, Tom
name: Mcgauran, Rob
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 3304
subject: Urban and regional planning

description: This paper explores the redevelopment potential of ageing and underutilised public housing properties in the middle suburbs of major Australian cities. State governments lack strategies for the renewal of this housing in the current fiscally constrained environment. Responding to this need, this paper presents a design research project that proposes a coordinated, precinct-based regeneration strategy that involves the redevelopment of clusters of public housing lots that are in close proximity to each other. It demonstrates how such a precinct-scaled approach can produce a greater diversity of housing types that achieve higher yields as well as better quality urban amenity and infrastructure. This is in contrast to the inefficient, piecemeal infill housing development currently prevalent in middle suburban areas. The paper describes the results of developing and testing this design research proposal. A mapping survey of the Victorian Government's public housing portfolio found that around 25% of assets form precinct scale clusters of renewable stock in well-serviced middle suburbs. Integrative redevelopment strategies were formulated for selected localised clusters, including customised arrangements of density, uses, parking and dwelling types. At the same time, targeted public realm enhancements were developed to encourage existing community assets to 'work harder'. These strategies were trialled and developed through innovative design-led community engagements, and then formalised into detailed design scenarios that enabled the testing of short and long-term viability relative to 'status quo' development models. The results of this analysis indicate how the quantity and distribution of public housing stock presents a timely opportunity for broader regeneration of ageing middle suburbs -recognised as vital to achieving sustainable metropolitan housing growth and diversity within equitable and liveable cities. Finally, this paper examines the role for community housing organisations in leveraging public investment in regeneration while preserving affordability in key areas.
title: Resonancia magnética en el estudio de las neoplasias malignas de vagina
Creators: name: Garcia Roa, María Dolores
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Pelvis
subject: Genital / Reproductive system female

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
El carcinoma primario de vagina constituye tan sólo el 2-3% de los tumores malignos ginecológicos y es la 5ª neoplasia en frecuencia tras los carcinomas de ovario,
útero,
cérvix y vulva.
Se define como aquella neoplasia derivada sólo de la...
title: Técnicas de imagen diagnóstica en los paragangliomas.
Creators: name: Santamaria Jareño, Sonia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Molecular imaging
subject: Ultrasound-Colour Doppler
subject: CT
subject: MR
subject: Vascular
subject: Nuclear medicine
subject: Head and neck

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar las manifestaciones radiológicas de los paragangliomas en diferentestécnicas de imagen diagnóstica: ecografía,tomografía computarizada,
resonancia magnética. Demostrar la utilidad de la medicina nucleary la angiografía en el...
Series solution for a cylindrical composite shell subject to axisymmetric loadings.
Creators: name: Lindstrom, Douglas W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Mechanical.

description: The elasticity equations have been solved to an arbitrary degree of precision for a thick-walled orthotropic cylinder, subject to axisymmetric loading. The theory is directly applicable to a layered composite material where each layer is orthotropic in character. The solution proceeds by representing the deformations of the cylinder wall as a power series in a non-dimensional radial parameter. By introducing a generalized stress resultant and a generalized stiffness for the material, a series of coupled second order differential equations in the coefficients of the deformation series results. These have been solved using a generalized eigenvalue technique for an infinitely long cylinder, a simply held cylinder, and a rigidly clamped cylinder. The solution has been shown to reduce to standard shell solutions for thin cylinders. A thick-walled filament wound test specimen is also detailed that when fabricated and pressurized, would experimentally verify the refined theory developed.
Continuous Integration for Research Software Engineering
Creators: name: Fritz, Jakob
name: Barrios Sazo, Maria Guadalupe
name: Brömmel, Dirk
name: Speck, Robert
Publisher: name: Forschungzentrum Jülich
Year: 2024

description: Lecture at RSE Summer School (Karlsruhe, Germany), 23 Sep 2024 - 27 Sep 2024