cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Toward volume manufacturing of high-performance soft x-ray critical-angle transmission gratings
Creators: name: Heilmann, Ralf K.
name: Bruccoleri, Alexander R.
name: Song, Jungki
name: Cook, Matthew T.
name: Gregory, James A.
name: Lambert, Renee D.
name: Shapiro, Dimitri A.
name: Young, Douglas J.
name: Bradshaw, Miranda
name: Burwitz, Vadim
name: Hartner, Gisela D.
name: Langmeier, Andreas
name: Smith, Randall K.
name: Schattenburg, Mark L.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: High-resolution ($R = λ/Δλ> 2000$) x-ray absorption and emission line spectroscopy in the soft x-ray band is a crucial diagnostic for the exploration of the properties of ubiquitous warm and hot plasmas and their dynamics in the cosmic web, galaxy clusters, galaxy halos, intragalactic space, and star atmospheres. Soft x-ray grating spectroscopy with $R > 10{,}000$ has been demonstrated with critical-angle transmission (CAT) gratings. CAT gratings combine the relaxed alignment and temperature tolerances and low mass of transmission gratings with high diffraction efficiency blazed in high orders. They are an enabling technology for the proposed Arcus grating explorer and were selected for the Lynx design reference mission grating spectrometer instrument. Both Arcus and Lynx require the manufacture of hundreds to perhaps $\approx 2000$ large-area CAT gratings. We are developing new patterning and fabrication process sequences that are conducive to large-format volume processing on state-of-the-art 200 mm wafer tools. Recent x-ray tests on 200 nm-period gratings patterned using e-beam-written masks and 4x projection lithography in conjunction with silicon pore focusing optics demonstrated $R \approx 10^4$ at 1.49 keV. Extending the grating depth from 4 $μ$m to 6 $μ$m is predicted to lead to significant improvements in diffraction efficiency and is part of our current efforts using a combination of deep reactive-ion etching and wet etching in KOH solution. We describe our recent progress in grating fabrication and report our latest diffraction efficiency and modeling results.
description: 11 pages, 8 figures, submitted to Proc. SPIE 11444
Molecular cloning and characterization of sesquiterpene synthases from valeriana officinalis
Creators: name: Pyle, Bryan Wilkinson
Publisher: name: Graduate Studies
Year: 2012
Subjects: subject: Biochemistry
subject: Valeriana officinalis
subject: valerenic acid
subject: valerena-4,7(11)-diene

description: Valeriana officinalis (valerian) is a popular medicinal plant in North America and Europe. Its root extract is commonly used as a mild sedative and anxiolytic. Valerenic acid, a C15 sesquiterpenoid, has been suggested as the active ingredient responsible for the sedative effect. Recently, medical uses of valerenic acid as anti-depressant and anti-inflammatory drugs were suggested due to its affinity for the γ-aminobutyric acid type A (GABAA) receptor as an agonist and its inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, respectively. Despite its importance, biochemistry of valerenic acid in valerian remains unknown. To identify the first committed enzymatic step in valerenic acid biosynthesis, next-generation sequencing (Roche 454 titanium) was used to generate ~1 million transcript reads from valerian root. Subsequently, three cDNAs for sesquiterpene synthases (VoTPS1/2/3) were identified and their corresponding recombinant enzymes were purified. Three recombinant enzymes efficiently catalyze the synthesis of valerena-4,7(11)-diene, germacrene C/D, and drimenol, respectively, based on the spectral match in the mass spectrometry library. Additional structural analyses using GC-MS and 13C-NMR spectrometry in comparison to a semi-synthesized standard confirmed the chemical identity of valerena-4,7(11)-diene. This is the first report of valerena-4,7(11)-diene and drimenol synthases, and the biosynthetic mechanisms of these two products from the substrate, farnesyl diphosphate, were proposed.
THEORETICAL AND PRACTICAL BASICS OF CREATING MODERN ELECTRONIC DICTIONARIES
Creators: name: Sadikova, Sevinch
Publisher: name: Zenodo
Year: 2023

description: It is known that language is not only a means of communication, but also a cultural factor in the existence, development of each nation, human society as a whole, since language is a natural condition for the preservation and transmission of what is mined by mankind in the process of verbal knowledge of objective reality, a vital, as well as spiritual experience is expressed in the global picture of the world created by each nation.
Additional file 1 of LeafGo: Leaf to Genome, a quick workflow to produce high-quality de novo plant genomes using long-read sequencing technology
Creators: name: Driguez, Patrick
name: Bougouffa, Salim
name: Carty, Karen
name: Putra, Alexander
name: Jabbari, Kamel
name: Reddy, Muppala
name: Soppe, Richard
name: Cheung, Ming Sin
name: Fukasawa, Yoshinori
name: Ermini, Luca
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary materials. Includes supplementary results and all supplementary tables (S1-S8) and figures (S1-S12).
Evolution in the clustering strength of radio galaxies
Creators: name: Fine, S.
name: Shanks, T.
name: Nikoloudakis, N.
name: Sawangwit, U.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We cross match the NVSS and FIRST surveys with three large photometric catalogues of luminous red galaxies (LRGs) to define radio-loud samples. These have median redshifts 0.35, 0.55 and 0.68 and, by matching rest-frame optical and radio properties, we construct uniform samples across the three surveys. This paper is concerned with the clustering properties of these samples derived from the angular correlation function. The primary aim is to characterise any evolution in the clustering amplitude of radio galaxies bellow z~0.68. We find no evidence for evolution in the large-scale (~1-50h^{-1}Mpc) clustering amplitude. Our radio galaxy autocorrelations are consistent with previous findings indicating little-to-no evolution in the redshift range 0.68 to 0 (~6Gyr of time). We also cross correlate radio galaxies with the parent LRG samples to increase the precision of our results and again find no evidence for evolution. Our results are inconsistent with a long-lived model for the clustering evolution that assumes radio sources randomly sample the LRG population. A model where the halo mass is constant with redshift is consistent with the data. This is similar to QSOs that have clustering amplitudes consistent with a single halo mass at all redshifts. Given that the brightest radio sources show stronger evolution in space density compared to fainter radio sources we restrict our samples to include only objects with L>10^{26}W/Hz and repeat the analysis. Again we find no evidence for evolution in the comoving correlation amplitude. These radio sources appear to inhabit the same mass halos as fainter radio galaxies (~9x10^{13}h^{-1}M_\odot). These halos are ~twice as massive as those of the general LRG population and ~30 times as massive as optical AGN/QSOs.
description: 9 pages, 8 figures, accepted MNRAS
Additional file 10 of Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development
Creators: name: Zhao, Yunpo
name: Lindberg, Bo Gustav
name: Esfahani, Shiva Seyedoleslami
name: Tang, Xiongzhuo
name: Piazza, Stefano
name: Engström, Ylva
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 10. Dfr-L overexpression causes defects. a Percentage of pupariation relative to time in hours after larval hatching. spok-Gal4 was applied to drive Dfr-L overexpression in dfr14 background (spok-Gal4 > dfr-L; dfr14). b Representative images of pupae. Compared to control w1118, the dfr14mutation and Dfr-L overexpression (in control and dfr14 background) increased pupal size. Dfr-L overexpression in dfr14 background caused pupal lethality. c Quantification of relative pupa volume of the genotypes in (b). Bars represent means +SE. Distinct lettering denote significantly different sizes (p < 0.05).
Core-collapse supernova enrichment in the core of the Virgo Cluster
Creators: name: Million, E. T.
name: Werner, N.
name: Simionescu, A.
name: Allen, S. W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using a deep (574 ks) Chandra observation of M87, the dominant galaxy of the nearby Virgo Cluster, we present the best measurements to date of the radial distribution of metals in the central intracluster medium (ICM). Our measurements, made in 36 independent annuli with $\sim$250,000 counts each, extend out to a radius r$\sim$40 kpc and show that the abundance profiles of Fe, Si, S, Ar, Ca, Ne, Mg, and Ni are all centrally peaked. Interestingly, the abundance profiles of Si and S - which are measured robustly and to high precision - are even more centrally peaked than Fe, while the Si/S ratio is relatively flat. These measurements challenge the standard picture of chemical enrichment in galaxy clusters, wherein type Ia supernovae (SN Ia) from an evolved stellar population are thought to dominate the central enrichment. The observed abundance patterns are most likely due to one or more of the following processes: continuing enrichment by winds of a stellar population pre-enriched by SNCC products; intermittent formation of massive stars in the central cooling core; early enrichment of the low entropy gas. We also discuss other processes that might have contributed to the observed radial profiles, such as a stellar initial mass function that changes with radius; changes in the pre-enrichment of core-collapse supernova progenitors; and a diversity in the elemental yields of SN Ia. Although systematic uncertainties prevent us from measuring the O abundance robustly, indications are that it is about 2 times lower than predicted by the enrichment models.
description: 11 pages, 8 figures. Accepted for publication in MNRAS
On the capacity of deep generative networks for approximating distributions
Creators: name: Yang, Yunfei
name: Li, Zhen
name: Wang, Yang
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Probability (math.PR)
subject: Statistics Theory (math.ST)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We study the efficacy and efficiency of deep generative networks for approximating probability distributions. We prove that neural networks can transform a low-dimensional source distribution to a distribution that is arbitrarily close to a high-dimensional target distribution, when the closeness are measured by Wasserstein distances and maximum mean discrepancy. Upper bounds of the approximation error are obtained in terms of the width and depth of neural network. Furthermore, it is shown that the approximation error in Wasserstein distance grows at most linearly on the ambient dimension and that the approximation order only depends on the intrinsic dimension of the target distribution. On the contrary, when $f$-divergences are used as metrics of distributions, the approximation property is different. We show that in order to approximate the target distribution in $f$-divergences, the dimension of the source distribution cannot be smaller than the intrinsic dimension of the target distribution.
Novel Transfer Function Based Approaches for Analysis of Resting-State Connectivity in Patients with Optic Neuritis
Creators: name: Choudhury, Samiul Hayder
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Engineering--Electronics and Electrical
subject: Optic Neuritis
subject: Artificial Neural Network
subject: Receiver Operator Characteristic
subject: Simulated Annealing
subject: Bootstraping

description: Generating reliable imaging markers to study connectivity changes of brain regions associated with optic neuritis (ON) allows ON to be used as a system model for advanced treatment and pathology of multiple sclerosis (MS). Markers that can differentiate ON subject groups are obtained using new transfer function based approaches to characterize the connectivity paths of visual signal propagation. We suggest three thresholding methods to alleviate the effect of possible noisy peaks in the transfer function spectrum. Artificial neural networks (ANN) are used to provide an improved classifier via the integration of the proposed metrics. We propose a new simulated annealing approach to improve the sensitivity of ANN trained with small datasets such as obtained from ON data. We evaluate the ability of the metrics to differentiate between normal subjects and ON patients, with and without MS, using two-way and three-way receiver operator characteristics.
Products of non-sigma-lower porous sets
Creators: name: Rmoutil, Martin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 28A05, 54B10, 54E35, 54G20

description: It has been known that the Cartesian product of two Suslin non-sigma-porous sets in topologically complete metric spaces is non-sigma-porous in the product space. The main aim of the present paper is to answer the natural question whether a similar result can be proved for lower porosity. It apears the answer is no, as we construct closed non-sigma-lower porous subsets of the real line A and B such that the Cartesian product of A and B is lower porous. In the present article we provide an example of two closed non-sigma-lower porous sets with lower porous product. On the other hand, we prove the following: Let X and Y be topologically complete metric spaces, let A be a non-sigma-lower porous Suslin subset of X and let B be a non-sigma-porous Suslin subset of Y. Then the product of A and B is non-sigma-lower porous. We also provide a brief summary of some basic properties of lower porosity, including a simple characterization of Suslin non-sigma-lower porous sets in topologically complete metric spaces.
A Bayesian Federated Learning Framework with Online Laplace Approximation
Creators: name: Liu, Liangxi
name: Jiang, Xi
name: Zheng, Feng
name: Chen, Hong
name: Qi, Guo-Jun
name: Huang, Heng
name: Shao, Ling
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Federated learning (FL) allows multiple clients to collaboratively learn a globally shared model through cycles of model aggregation and local model training, without the need to share data. Most existing FL methods train local models separately on different clients, and then simply average their parameters to obtain a centralized model on the server side. However, these approaches generally suffer from large aggregation errors and severe local forgetting, which are particularly bad in heterogeneous data settings. To tackle these issues, in this paper, we propose a novel FL framework that uses online Laplace approximation to approximate posteriors on both the client and server side. On the server side, a multivariate Gaussian product mechanism is employed to construct and maximize a global posterior, largely reducing the aggregation errors induced by large discrepancies between local models. On the client side, a prior loss that uses the global posterior probabilistic parameters delivered from the server is designed to guide the local training. Binding such learning constraints from other clients enables our method to mitigate local forgetting. Finally, we achieve state-of-the-art results on several benchmarks, clearly demonstrating the advantages of the proposed method.
A Contradiction in Will: Understanding China's Strategic Culture in a Civil-Military Context
Creators: name: Rakebrand, Jeff
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Anthropology--Cultural
subject: History--Asia, Australia, and Oceania
subject: Military Studies
subject: Strategic Culture
subject: China
subject: People's Liberation Army
subject: Chinese Communist Party
subject: Civil-Military Relations

description: Given China’s civil-military relationship, how consistent is its military’s perspectives on the use of force with those of the party-state government? By adopting a cultural framework of analysis, this study utilizes a methodology rooted in social constructivism to examine the strategic policies of the party-state government, followed by an analysis of the government’s relationship with the military and its beliefs and values towards the use of force. Interactions between the ruling Chinese Communist Party and the People’s Liberation Army frame the discourse and narrative underscoring how military force is conceived, perceived and implemented within China. This study concludes that China’s use of force is impacted by the military’s willingness to use force on behalf of the party-state government. This impact is most evident in the internal use of force where trends suggest that the military’s interests conflict with those of the party-state government.
Oliver Grote, Die griechischen Phylen. Funktion – Entstehung – Leistungen. Stuttgart, Steiner 2016
Creators: name: Meister, Jan B.
Publisher: name: Humboldt-Universität zu Berlin
Year: 2018
Subjects: subject: 940 Geschichte Europas

description: Dieser Beitrag ist mit Zustimmung des Rechteinhabers (De Gruyter) frei zugänglich.
Modeling Time's Arrow
Creators: name: Jejjala, Vishnu
name: Kavic, Michael
name: Minic, Djordje
name: Tze, Chia-Hsiung
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Quantum gravity, the initial low entropy state of the Universe, and the problem of time are interlocking puzzles. In this article, we address the origin of the arrow of time from a cosmological perspective motivated by a novel approach to quantum gravitation. Our proposal is based on a quantum counterpart of the equivalence principle, a general covariance of the dynamical phase space. We discuss how the nonlinear dynamics of such a system provides a natural description for cosmological evolution in the early Universe. We also underscore connections between the proposed non-perturbative quantum gravity model and fundamental questions in non-equilibrium statistical physics.
description: 18 pages
Strong convexity for harmonic functions on compact symmetric spaces
Creators: name: Lippner, Gabor
name: Mangoubi, Dan
name: McGuirk, Zachary
name: Yovel, Rachel
Publisher: name: arXiv
Year: 2021
Subjects: subject: Spectral Theory (math.SP)
subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 43A85, Secondary 31C05, 22E30

description: Let $h$ be a harmonic function defined on a spherical disk. It is shown that $Δ^k |h|^2$ is nonnegative for all $k\in \mathbb{N}$ where $Δ$ is the Laplace-Beltrami operator. This fact is generalized to harmonic functions defined on a disk in a normal homogeneous compact Riemannian manifold, and in particular in a symmetric space of the compact type. This complements a similar property for harmonic functions on $\mathbb{R}^n$ discovered by the first two authors and is related to strong convexity of the $L^2$-growth function of harmonic functions.
description: 9 pages
Measuring the masses of a pair of semi-invisibly decaying particles in central exclusive production with forward proton tagging
Creators: name: Harland-Lang, L. A.
name: Kom, C. H.
name: Sakurai, K.
name: Stirling, W. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss how the mass of new physics particles involved in a pair of short decay chains leading to two invisible particles, for example slepton pair production, followed by the decay into two leptons and two neutralinos, may be measured in central exclusive production (CEP) with forward proton tagging. We show how the existing mass measurement strategies in CEP may be improved by making full use of the mass-shell constraints, and demonstrate that, with around 30 signal events, the masses of the slepton and neutralino can be measured with an accuracy of a few GeV.
description: 18 pages, 6 figures
Averaging curves under the dynamic time warping distance
Creators: name: van Greevenbroek, Koen
Publisher: name: Zenodo
Year: 2020
Subjects: Average curve problem
Dynamic time warping
1-Median
NP-hardness
Time series
Clustering

description: Master's thesis in mathematics at the University of Bonn. The average curve problem under the dynamic time warping distance plays an important role in analysing and clustering time series data, with applications ranging from biology and speech recognition to finances and energy. Despite substantial effort, however, the problem resists satisfactory solutions. Recent fundamental research on the average curve problem has given us a better understanding of the difficulties involved; NP-hardness was shown in 2019. We strengthen this further by proving that there is no polynomial time constant factor approximation algorithm unless P = NP. On the constructive side, we focus on the problem of finding constant length average curves. Using techniques from real algebraic geometry, we present the first polynomial time algorithm for this problem. We also give a more general (1 + ε)-approximation algorithm with a better time complexity than the exact algorithm.
Additional file 11 of Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development
Creators: name: Zhao, Yunpo
name: Lindberg, Bo Gustav
name: Esfahani, Shiva Seyedoleslami
name: Tang, Xiongzhuo
name: Piazza, Stefano
name: Engström, Ylva
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 11. Knockdown of dfr, as well as overexpression of Dfr-S/L reduces the expression of nvd, phm, dib, spok and sad mRNA. a. Quantification of mRNA in extracts of BRGCs using RT-qPCR after reducing dfr mRNA by RNAi or overexpression of UAS-dfr-S or UAS-dfr-L in larval PG using the Phm-Gal4ts driver. Downregulation of dfr or UAS-dfr-S overexpression significantly reduced the mRNA levels of nvd, phm, dib, spok and sad, while overexpression of UAS-dfr-L had a comparably weaker inhibitory effect on these target genes, albeit significant for all except nvd (*p < 0.05, **p < 0.01, ***p < 0.001). b. Upper panel: Immunoblot of protein extracts from S2 cells transfected with a constant amount of dfr-L and increasing amounts of dfr-S expressing plasmids. Dfr-S protein abundance correlates with increasing concentration of dfr-S plasmid, while Dfr-L protein abundance decreased when Dfr-S became predominant, albeit a constant concentration of dfr-L expression plasmid was transfected. Actin was used as a loading control. Bottom panel:quantification of relative protein expression levels. c. Schematic illustration of how both downregulation and overexpression of dfr may interfere with target gene expression. Upon downregulation (left panel) by RNAi, loss of both Dfr-S and Dfr-L abolishes expression of the ecdysone biosynthesis genes, as in (a). When balanced concentrations of Dfr-S, Dfr-L, Mld and other regulatory factors are present (middle panel) the target genes will be appropriately activated at a high level. The large sphere indicates the formation of an active transcription initiation complex, putatively in the form of a liquid phase condensate. Upon overexpression of either Dfr-S or Dfr-L (right panel), the unbalanced concentrations of regulatory factors will disturb the formation of active transcription initiation complexes, and result in weak target gene activation. In addition, overexpression of Dfr-S causes decreased abundance of Dfr-L, as in (b) and Fig. 8c-d).
title: Ð ÐµÑÐµÑÑÐ¸Ð²Ð½ÑÐµ Ð³ÐµÐ½Ñ, Ð¿ÑÐµÐ´ÑÐ°ÑÐ¿Ð¾Ð»Ð°Ð³Ð°ÑÑÐ¸Ðµ Ðº ÑÐ°ÐºÑ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ
title: Ð½Ð°ÑÑÐ½ÑÐ¹ Ð´Ð¾ÐºÐ»Ð°Ð´
titleType: Subtitle
title: Recessive genes predisposing to breast cancer
Creators: name: Ð¡Ð¾ÐºÐ¾Ð»Ð¾Ð²Ð°, Ð¢Ð°ÑÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð°Ñ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ñ
ÑÐ°Ðº Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ
Ð¿Ð¾Ð»Ð½Ð¾ÑÐºÐ·Ð¾Ð¼Ð½Ð¾Ðµ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
molecular oncology
breast cancer
whole exome sequencing

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿Ð¾Ð¸ÑÐºÑ ÑÐµÑÐµÑÑÐ¸Ð²Ð½ÑÑ Ð¼ÑÑÐ°ÑÐ¸Ð¹ Ð¿ÑÐµÐ´ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ðº ÑÐ°ÐºÑ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¿Ð¾Ð»Ð½Ð¾ÑÐºÐ·Ð¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾ÑÐ¾Ð±ÑÐ°Ð½Ð½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð² Ð±ÑÐ»Ð¾ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ ÐºÐ°Ð½Ð´Ð¸Ð´Ð°ÑÐ½ÑÑ Ð³Ð¾Ð¼Ð¾Ð·Ð¸Ð³Ð¾ÑÐ½ÑÑ (ÑÐµÑÐµÑÑÐ¸Ð²Ð½ÑÑ ) Ð¼ÑÑÐ°ÑÐ¸Ð¹. ÐÐ»Ñ Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð°Ð½Ð°Ð»Ð¸Ð· in silico Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾-ÑÐ¿Ð¸Ð´ÐµÐ¼Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾ ÑÑ ÐµÐ¼Ðµ Â«ÑÐ»ÑÑÐ°Ð¹-ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÂ». ÐÐ»Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÑÐ¾Ð»Ð¸ Ð¼ÑÑÐ°ÑÐ¸Ð¸ Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾-Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ¹ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ Ð¾Ñ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¸Ñ Ð¼ÑÑÐ°ÑÐ¸Ð¸ BRCA1 p.Gln356Arg.
description: The work is devoted to the search for recessive mutations of susceptibility to breast cancer. The whole exome sequencing of selected samples identified several candidate homozygous (biallelic) mutations. Analysis in silico and molecular epidemiological case â control study were performed. Breast tumors from carriers of BRCA1 p.Gln356Arg were analyzed for determination the role of the mutation in tumor development.
Modelling Riders' Behavioural Responses to Real-Time Information at LRT Stations in Calgary, Alberta
Creators: name: Bai, Yuan
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Engineering--Civil
subject: Advanced Passenger Information System
subject: Travellers’ behaviour
subject: Multinomial logit model

description: An Advanced Passenger Information System (APIS) can play a significant role in both improving the satisfaction of transit riders in the short term and increasing ridership in the long term. This research focuses on investigating riders’ behavioural responses to en-route Light Rail Transit (LRT) real-time information. A survey was designed and conducted to collect LRT riders’ psychological perception and behavioural responses in Calgary, Alberta. Four scenarios were examined by presenting hypothetical scenarios: an estimated next LRT arrival time of 10 minutes, an LRT service interruption with no information on expected recovery time, presentation of conflicting information while LRT service was interrupted, and oncoming crowded LRT trains. A total of 505 responses were collected. Multinomial logit models were developed and calibrated to explore the factors affecting trip decision-making for the described scenarios for commuter and non-commuter trips. The results led to the conclusion that various socio-economic attributes (i.e., age, gender, number of automobiles per household), experience with APIS system (familiarity with accessing APIS and the perceived accuracy of the information it provides), experience with public transit in general and the Calgary’s LRT system in particular (i.e., use of transit as the primary mode of transportation, frequency of LRT use, and familiarity with LRT) and the characteristics of the original LRT stations had strong influences on travellers’ behavioural responses in the context of real-time LRT information. It was also determined that travellers’ actions vary by trip purpose, trip time, and weather conditions.
Duality for double iterated outer $L^p$ spaces
Creators: name: Fraccaroli, Marco
Publisher: name: arXiv
Year: 2021
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 42B35, 46E30

description: We study the double iterated outer $L^p$ spaces, namely the outer $L^p$ spaces associated with three exponents and defined on sets endowed with a measure and two outer measures. We prove that in the case of finite sets, under certain conditions between the outer measures, the double iterated outer $L^p$ spaces are isomorphic to Banach spaces uniformly in the cardinality of the set. We achieve this by showing the expected duality properties between them. We also provide counterexamples demonstrating that the uniformity does not hold in any arbitrary setting on finite sets, at least in a certain range of exponents. We prove the isomorphism to Banach spaces and the duality properties between the double iterated outer $L^p$ spaces also in the upper half $3$-space infinite setting described by Uraltsev, going beyond the case of finite sets.
description: 44 pages, no figures
Microtubules and fertilization: The MEI-1/Katanin mediated cytoskeletal transition from meiosis to mitosis in the developing C. elegans embryo
Creators: name: Beard, Sarah Marie
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: MEI-1
subject: Katanin
subject: Mitosis
subject: Meiosis
subject: Microtubules

description: During embryonic development, dramatic changes of the C. elegans cytoskeleton occur in the transition from the meiosis to mitosis requiring precise regulation of molecules specific to each type of spindle. The microtubule severing complex, MEI-1/MEI-2, is required for C. elegans meiotic spindle formation, but must be inactivated to prevent disruption of mitosis. There are several redundant pathways involved in this tightly regulated process. In order to determine how known genes of these pathways function relative to one another, I have developed a robust antibody-staining assay to measure anti-MEI-1 protein levels based on total pixel intensity in early embryogenesis. Using this assay, I have shown that APC and MBK-2 act strictly sequentially with one another to degrade MEI-1. I have also shown that ectopic MEI-1 staining in cul-2 and rfl-1 are enhanced by mel-26 and not by mbk-2 indicating that CUL-2 and MBK-2 are working together to degrade MEI-1 in parallel to the MEL-26/CUL-2 pathway and that RFL-1 is activating CUL-2 in this process. hecd-1 ectopic MEI-1 staining was not enhanced by any of the known regulatory genes in this process and might be inhibiting an activator of MEI-1. This project will assist in decoding the key regulatory molecules of the developmental remodelling in early embryos.
Exit strategies in prison and probation report
Creators: name: Costa, Vítor
name: Esgalhado, Graça
name: Cunha, Ana Isabel
Publisher: name: Zenodo
Year: 2020
Subjects: deradicalization
exit programmes
radicalization
intervention programmes
ideology

description: This report aims to map current exit programmes for prison and/or probation settings. Considering the goals and scope of the project, the programmes presented in this report are mostly from European Countries, representing institutional interventions that are implemented on a regular basis. The introduction of the report addresses key characteristics of exit programmes (i.e., who is the actor; what is the contact approach; and how relevant is the ideological component) as well as the range of interventions that can be part of these programmes (i.e., individual mentoring; mental health care and counselling; reintegration services). Section 2 of the report summarises exit programmes implemented in prisons. With a focus on the European reality, programmes in the United Kingdom (UK) (i.e., Healthy Identity Intervention), Denmark (i.e., Back on Track), Germany (i.e., Radicalisation Prevention and Deradicalisation in Prison and Probation - VPN; and Network for Deradicalisation in Corrections – Federal State of Hesse), Austria (i.e., De-radicalisation in Prisons), and Norway (i.e., Mentoring Scheme) are presented. Intervention programmes in prisons from other regions are also explored, with examples from Africa (i.e., Nigeria) and Middle East (i.e., Israel). Section 3 proceeds with examples from exit programmes in probation contexts in countries such as the UK (i.e., The Unity Initiative), France (i.e., Research and Intervention on Violent Extremism) and the Netherlands (i.e., Terrorism, Extremism and Radicalisation team of the Dutch Probation Service). Ending the report, the conclusions and what works section summarises the main findings of the previous sections, drawing conclusions based on the literature review (e.g., the need for multidisciplinary teams; tailor-made nature of the programmes; importance of a post-incarceration monitoring phase). Annex I summarises the described exit programmes in European Prisons.
Principles of High-Dimensional Data Visualization in Astronomy
Creators: name: Goodman, Alyssa A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Astronomical researchers often think of analysis and visualization as separate tasks. In the case of high-dimensional data sets, though, interactive exploratory data visualization can give far more insight than an approach where data processing and statistical analysis are followed, rather than accompanied, by visualization. This paper attempts to charts a course toward "linked view" systems, where multiple views of high-dimensional data sets update live as a researcher selects, highlights, or otherwise manipulates, one of several open views. For example, imagine a researcher looking at a 3D volume visualization of simulated or observed data, and simultaneously viewing statistical displays of the data set's properties (such as an x-y plot of temperature vs. velocity, or a histogram of vorticities). Then, imagine that when the researcher selects an interesting group of points in any one of these displays, that the same points become a highlighted subset in all other open displays. Selections can be graphical or algorithmic, and they can be combined, and saved. For tabular (ASCII) data, this kind of analysis has long been possible, even though it has been under-used in Astronomy. The bigger issue for Astronomy and several other "high-dimensional" fields is the need systems that allow full integration of images and data cubes within a linked-view environment. The paper concludes its history and analysis of the present situation with suggestions that look toward cooperatively-developed open-source modular software as a way to create an evolving, flexible, high-dimensional, linked-view visualization environment useful in astrophysical research.
description: 10 pages, 9 figures, expected to appear in Astron. Nachr. 333, No.5/6,505-514 (2012) Invited Plenary at 2011 Astronomische Gesellschaft, "Surveys and Simulations: The Real and the Virtual Universe"
title: Fachkräfte-Radar für KiTa und Grundschule 2023
Creators: name: Bock-Famulla, Kathrin
name: Girndt, Antje
name: Berg, Eva
name: Vetter, Tim
name: Kriechel, Ben
Publisher: name: Bertelsmann Stiftung
Year: 2023
Subjects: Kindertagesbetreuung
Grundschule
Frühkindliche Bildung
Fachkräfte
Personalausstattung

description: Nach wie vor gibt es nicht genügend Betreuungsplätze für Kinder, um den Rechtsanspruch auf eine Kindertagesbetreuung zu erfüllen, wenn Eltern diese wünschen; zudem schwankt die Qualität der Kindertageseinrichtungen (KiTas) stark zwischen den Bundesländern und auch innerhalb der einzelnen Länder, so dass die Bildungs- und Teilhabechancen der Kinder wohnortabhängig sind. Inwieweit hier der aktuelle Mangel an Fachkräften  in den Sozial- und Erziehungsberufen kurz- wie auch langfristig ein Hindernis darstellt, muss pro Bundesland datenbasiert untersucht werden. Der Fachkräfte-Radar für KiTa und Grundschule prognostiziert in sieben Szenarien bis 2025 und 2030 die Entwicklung des Fachkräftebedarfs und -angebots in KiTas; betrachtet wird die Altersgruppe der Kinder bis zum Eintritt in die Schule. Im Fokus steht die Frage, ob ein bedarfsgerechter Zugang zu KiTas sowie eine bessere Personalausstattung realisiert werden könnten. Ein zentrales Ergebnis: Bis 2030 können in Ostdeutschland und auch in den meisten westdeutschen Bundesländern sowohl die aktuellen Elternbedarfe erfüllt als auch die zum Teil günstige Personalausstattung gehalten oder auf das mittlere Westniveau verbessert werden. Ebenfalls in Ostdeutschland – und auch in Hamburg – besteht, neben der Erfüllung der Platzbedarfe, sogar zusätzlich die Möglichkeit, mit einiger Anstrengung eine kindgerechte Personalausstattung nach wissenschaftlichen Empfehlungen zu erreichen.
Encoding Of Regularity In The Visual Cortex
Creators: name: Kubilius, Jonas
name: Wagemans, Johan
name: Op de Beeck, Hans P.
Publisher: name: Zenodo
Year: 2013

description: The visual system is very efficient in encoding stimulus properties. To explore the underlying encoding strategies in the early stages of visual information processing, we presented participants with L-, T-, and X-junctions in a functional magnetic resonance imaging (fMRI) experiment. For each junction type, we manipulated the amount of configuration regularity (or degrees of constraint), ranging from a generic junction configuration to stimuli resembling an ‘L’ (i.e., a right angle L-junction), a ‘T’ (i.e., a right angle midpoint T-junction), or a ‘+’. We found that the response strength in the shape-selective lateral occipital area was consistently lower for a higher degree of regularity in the stimuli. In the second experiment, using multivoxel pattern analysis we further show that regularity is encoded in terms of the fMRI signal strength but not in the distributed pattern of responses. Finally, we found that the results of these experiments could not be accounted for by two well-known theoretical proposals for constructing stimulus interpretation, namely, the Structural Information Theory and the Minimal Model Theory, at least not without additional assumptions in those theories. Our results suggest that regularity plays an important role in stimulus encoding in the ventral visual processing stream.
TOG domain-tubulin interactions and the function of the Arabidopsis Microtubule Organization 1 protein
Creators: name: Zhang, Yi
Publisher: name: University of British Columbia
Year: 2010

description: Microtubules are indispensible cellular components involved in multiple core processes such as cell division and intra cellular trafficking. Elaborate regulatory mechanisms are required to direct the precise functioning of these highly dynamic structures. Microtubule-Associated Proteins (MAPs) often perform regulatory functions in controlling microtubule dynamics. Distortion of the function of Arabidopsis Microtubule Organization protein1 (MOR1) leads to various developmental defects. However, the mechanism through which MOR1 regulates microtubule function is poorly understood. We have hypothesized that each TOG domain of MOR1 physically binds with tubulin dimers to directly regulate their addition and removal from the microtubule polymer. To address this hypothesis, we aimed to identify interaction sites between the MOR1 protein and tubulins through a genetic interaction strategy. Three left-handed twisting mor1 mutants were each crossed with sixteen right-handed twisting tubulin mutants, and pronounced genetic interactions were detected by observing non-additive and allele-specific phenotypes. Notably, tubulin point mutations in the interface between the β-tubulin at the plus end of the microtubules and the α-tubulin of the incoming dimer generated the most synergistic phenotypes when combined with the mor1 alleles. Live cell imaging of microtubules confirmed that allele-specific variations in growth phenotypes were correlated with altered microtubule dynamics. The MOR1-tubulin interaction model was further tested through the characterization of a new mor1 allele in the TOG3 domain of MOR1, mor1-11, which was determined to have a semi-dominant propyzamide-dependent right-handed twisting phenotype and microtubule organization and dynamics were found to be altered by propyzamide treatment. However, the distinct right-handed twisting phenotype, and to some extent the altered microtubule organization is lost at higher temperature, suggesting that the intrinsic increase in microtubule dynamics at 31°C overrides mor1-11’s effect. The tua6C²¹³Y single mutant, which was reported to have similar right-handed twisting upon propyzamide treatment, continues to twist in a right-handed manner at 31°C and mor1-11tua6C²¹³Y double mutants are indistinguishable from tua6C²¹³Y single mutants on propyzamide at either 21°C or 31°C. Together, these observations suggest that tubulin is more likely than MOR1 to be a direct target of propyzamide and that the motif identified by the mor1-11 mutation could play a key role in the interactions on MOR1 with α-tubulin.
On the Evolution and Survival of Protoplanets Embedded in a Protoplanetary Disk
Creators: name: Vazan, Allona
name: Helled, Ravit
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We model the evolution of a Jupiter-mass protoplanet formed by the disk instability mechanism at various radial distances accounting for the presence of the disk. Using three different disk models, it is found that a newly-formed Jupiter-mass protoplanet at radial distance of $\lesssim$ 5-10 AU cannot undergo a dynamical collapse and evolve further to become a gravitational bound planet. We therefore conclude that {\it giant planets, if formed by the gravitational instability mechanism, must form and remain at large radial distances during the first $\sim$ 10$^5-10^6$ years of their evolution}. The minimum radial distances in which protoplanets of 1 Saturn-mass, 3 and 5 Jupiter-mass protoplanets can evolve using a disk model with $\dot{M}=10^{-6} M_{Sun}/yr$ and $α=10^{-2}$ are found to be 12, 9, and 7 AU, respectively. The effect of gas accretion on the planetary evolution of a Jupiter-mass protoplanet is also investigated. It is shown that gas accretion can shorten the pre-collapse timescale substantially. Our study suggests that the timescale of the pre-collapse stage does not only depend on the planetary mass, but is greatly affected by the presence of the disk and efficient gas accretion.
description: 26 pages, 2 tables, 10 figures. Accepted for publication in ApJ
Entire minimal parabolic trajectories: the planar anisotropic Kepler problem
Creators: name: Barutello, Vivina
name: Terracini, Susanna
name: Verzini, Gianmaria
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We continue the variational approach to parabolic trajectories introduced in our previous paper [5], which sees parabolic orbits as minimal phase transitions. We deepen and complete the analysis in the planar case for homogeneous singular potentials. We characterize all parabolic orbits connecting two minimal central configurations as free-time Morse minimizers (in a given homotopy class of paths). These may occur for at most one value of the homogeneity exponent. In addition, we link this threshold of existence of parabolic trajectories with the absence of collisions for all the minimizers of fixed-ends problems. Also the existence of action minimizing periodic trajectories with nontrivial homotopy type can be related with the same threshold.
description: 28 pages, 4 figures
Additional file 12 of Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development
Creators: name: Zhao, Yunpo
name: Lindberg, Bo Gustav
name: Esfahani, Shiva Seyedoleslami
name: Tang, Xiongzhuo
name: Piazza, Stefano
name: Engström, Ylva
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12. Dfr regulates the expression of Nvd, Phm and Sad. a, c, e Prothoracic glands (PGs) carrying GFP-labelled flp-out clones that express different transgenes (control, UAS-dfr-RNAi, UAS-dfr-S, and UAS-dfr-L). Induction of flp-clones as described in Fig. 8. The PGs were stained with anti-Nvd (a), anti-Phm (c) and anti-Sad (e), and shown in magenta (upper panels) or gray (lower panels). Immunofluorescence of Nvd, Phm and Sad was reduced or totally abolished in UAS-dfr-RNAi, UAS-dfr-S, and UAS-dfr-L clones. Scale bars 25 μM. b, d, f Quantification of the relative fluorescence in (a), (c) and (e) respectively (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).
Additional file 2 of LeafGo: Leaf to Genome, a quick workflow to produce high-quality de novo plant genomes using long-read sequencing technology
Creators: name: Driguez, Patrick
name: Bougouffa, Salim
name: Carty, Karen
name: Putra, Alexander
name: Jabbari, Kamel
name: Reddy, Muppala
name: Soppe, Richard
name: Cheung, Ming Sin
name: Fukasawa, Yoshinori
name: Ermini, Luca
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Review history.
Metabolomic and lipidomic profiling of the effect of edelfosine treatment on Saccharomyces cerevisiae
Creators: name: Tambellini, Nicolas Pietro
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Biochemistry
subject: Metabolomics
subject: Lipidomics
subject: Edelfosine
subject: Anti-tumour lipid
subject: yeast

description: Edelfosine is a lysophosphatidylcholine analogue and the prototype of a new class of compounds being investigated for their potential as highly selective chemotherapeutic agents. Edelfosine has been implicated as affecting numerous different metabolic pathways, though its mechanism of action is not well understood at this time. To gain further insight into edelfosine’s mechanism of action we carried out mass spectrometry based metabolomic and lipidomic profiling of yeast exposed to a cytostatic concentrations of edelfosine. Using multivariate projection methods and statistical analysis, we determined that edelfosine exerts a significant effect on many aspects of yeast metabolism. Metabolic pathways that were found to be perturbed included those involved with amino acid metabolism, sugar metabolism, the TCA cycle, fatty acid biosynthesis, sphingolipid metabolism, glycerophospholipid metabolism and glycerolipid metabolism. It was also observed that there is a kinetic difference in the response of polar and non-polar metabolites to edelfosine treatment in yeast.
Local well-posedness of a system describing laser-plasma interactions
Creators: name: Herr, Sebastian
name: Kato, Isao
name: Kinoshita, Shinya
name: Spitz, Martin
Publisher: name: arXiv
Year: 2021
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: A degenerate Zakharov system arises as a model for the description of laser-plasma interactions. It is a coupled system of a Schrödinger and a wave equation with a non-dispersive direction. In this paper, a new local well-posedness result for rough initial data is established. The proof is based on an efficient use of local smoothing and maximal function norms.
description: supersedes arXiv:2103.05340