title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐ°ÐºÑÐ° Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ð¹ Ð² Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ½Ð¾-Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ Ð¾Ð´Ð½Ð¾Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð³Ð¾ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Optical path of the hardware-software complex for single-molecule sequencing
Creators: name: Ð¡ÐµÑÐ¾Ð², ÐÐ³Ð¾Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð¤Ð»ÑÐ¾ÑÐµÑÑÐµÐ½ÑÐ¸Ñ
ÐÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½Ð¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ½Ð¾-Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½ÑÐ¹ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ
Ð¾Ð´Ð½Ð¾Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ðµ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð´ÐµÑÐµÐºÑÐ¾Ñ
Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÐ°ÐºÑ
Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½Ð¾Ðµ ÑÐ°Ð·Ð´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÐ¿ÐµÐºÑÑÐ°
hardware-software complex
single-molecule sequencing
optical detector
optical path
spatial separation of the spectrum

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐ°ÐºÑÐ° ÐÐÐÐÐ¡ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ð¹. ÐÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ ÑÐ¸Ð³Ð½Ð°Ð»Ð° ÑÐ»ÑÐ¾ÑÐµÑÑÐµÐ½ÑÐ¸Ð¸ ÐµÐ´Ð¸Ð½Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð° Ð¾Ñ: Ð´Ð¸Ð°Ð¼ÐµÑÑÐ° ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ñ, Ð¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð²Ð´Ð¾Ð»Ñ Ð¾ÑÐ¸ y Ð²Ð½ÑÑÑÐ¸ ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ñ, ÑÐ¼ÐµÑÐµÐ½Ð¸Ñ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ ÑÐµÐ½ÑÑÐ° ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ñ Ð¿Ð¾ Ð¾ÑÐ¸ x. Ð¢Ð°ÐºÐ¶Ðµ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÑÐµÐ´ÑÐµÐ³Ð¾ ÑÐµÑÐµÐ· ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ ÑÐ²ÐµÑÐ¾Ð´Ð¸Ð¾Ð´Ð° Ð´Ð»Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð´Ð»Ð¸Ð½ Ð²Ð¾Ð»Ð½ Ð¾Ñ: Ð´Ð¸Ð°Ð¼ÐµÑÑÐ° ZMW Ð½Ð°Ð½Ð¾Ð¾ÑÐ²ÐµÑÑÑÐ¸Ñ, ÑÐ³Ð»Ð° Ð¿Ð°Ð´ÐµÐ½Ð¸Ñ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ, Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ ÑÐ²ÐµÑÐ¾Ð´Ð¸Ð¾Ð´Ð°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð½Ð¾Ð²Ð¸Ð·Ð½Ð¾Ð¹, ÑÐ°Ðº ÐºÐ°Ðº ÑÑÐ¸ÑÑÐ²Ð°ÑÑ ÑÐ¿ÐµÑÐ¸ÑÐ¸ÐºÑ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ SMRT Ð² Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÐÐÐÐÐ¡. Ð£ÑÑÐµÐ½Ñ ÑÐµÑÐ¼Ð¸Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ´Ð¼ÐµÑÐ½Ð¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½ÑÐµ ÑÑÐµÐ´ÑÑÐ²Ð° Ð´Ð»Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð·Ð°Ð´Ð°Ñ. ÐÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¾ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ðµ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾-Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ: ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ðµ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ Ð´Ð»Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð².
description: The given work is devoted to modeling the optical tract of HSCSMS. The dependences of the fluorescence signal power of a single nucleotide on the diameter of the ZMW nanohole, positing along the y axis inside the ZMW nanohole, and displacement relative to the center of the ZMW nanohole along the x axis were obtained. The dependences of the power of the LED radiation transmitted through the ZMW nanohole were also obtained for various wavelengths on: the diameter of the ZMW nanohole, the angle of incidence of the radiation, and the radiation power of the LED. The obtained dependencies are scientifically novel since they take into account the specifics of the implementation of the SMRT technology in the domestic development of APCOS. The terminological features of the subject area are taken into account and software tools are used to solve problems. Specialized software and mathematical software were used: modern software for modeling physical processes.