cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Effects of replacing dietary fish oil and fish meal with microbial oil and algal biomass on lipid class, total fatty acid and phospholipid fatty acid composition of Atlantic salmon liver and muscle tissues
Creators: name: Guerra, Nigel Ivan
Publisher: name: Memorial University of Newfoundland
Year: 2022

description: With the continuous growth of aquaculture comes a growing demand for an alternative lipid source for fish oil (FO) and fish meal (FM) in aquafeeds. Certain microorganisms provide a potential sustainable replacement for FO and FM due to their content of omega-3 (ω3) long-chain polyunsaturated fatty acids, which are essential for the growth and health of fish. Two feeding trials were conducted to determine the effects of replacing FO and FM with oil and biomass from two different microorganism species. The first feeding trial comprised of replacing FO with a microbial oil (MO) derived from a novel strain, Schizochytrium sp. (strain T18), in diets for Atlantic salmon. Four experimental diets were developed: a fish oil control diet (FO), a blend of fish oil/canola oil control diet (FO/CO), a fish oil replacement with low proportions of microbial oil diet (LMO), and a fish oil replacement with high proportions of microbial oil diet (HMO). After 16 weeks of feeding, there were no significant effects on growth parameters across the dietary treatments. Fatty acid profiles reflected the diets with DHA being present in high proportions in the tissues, especially in the cellular membrane. The purpose of the second feeding trial was to reduce FO and replacing FM with algal biomass (AB) derived from Pavlova sp. strain CCMP459 (Pav459) in diets for Atlantic salmon. Three experimental diets were developed: a fish meal control diet (FM), a blend of a fish meal/algal biomass Pav459 diet (FM/AB), and a complete FM replacement with algal biomass Pav459 diet (AB). After 12 weeks of feeding, again, there was no significant effect on growth paraments, and the fatty acid profiles also reflected those of the diets. The DHA was present in high proportions in the tissues for all dietary treatments, especially the cellular membrane. The stable isotope data suggested a direct integration of EPA and DHA and not biosynthesis from its precursor ALA.
TemplateFlow: FAIR-sharing of multi-scale, multi-species brain models.
Creators: name: Ciric, Rastko
name: Thompson, William H
name: Lorenz, Romy
name: Goncalves, Mathias
name: MacNicol, Eilidh E
name: Markiewicz, Christopher J
name: Halchenko, Yaroslav O
name: Ghosh, Satrajit S
name: Gorgolewski, Krzysztof J
name: Poldrack, Russell A
name: Esteban, Oscar
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Brief Communication
/631/114/794
/706/648/697/129
/692/308/575
/631/114/116
/631/114/1564
brief-communication

description: Funder: Laura and John Arnold Foundation (Arnold Foundation); doi: https://doi.org/10.13039/100009827
description: Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/100004440
description: Funder: Kings College London; doi: https://doi.org/10.13039/501100000764
description: Reference anatomies of the brain ('templates') and corresponding atlases are the foundation for reporting standardized neuroimaging results. Currently, there is no registry of templates and atlases; therefore, the redistribution of these resources occurs either bundled within existing software or in ad hoc ways such as downloads from institutional sites and general-purpose data repositories. We introduce TemplateFlow as a publicly available framework for human and non-human brain models. The framework combines an open database with software for access, management, and vetting, allowing scientists to share their resources under FAIR-findable, accessible, interoperable, and reusable-principles. TemplateFlow enables multifaceted insights into brains across species, and supports multiverse analyses testing whether results generalize across standard references, scales, and in the long term, species.
title: Threshold effects and the line shape of the X(3872) in effective field theory
Creators: name: Schmidt, Marcel
name: Jansen, M.
name: Hammer, Hans-Werner
Publisher: name: American Physical Society
Year: 2022

description: Latest measurements suggest that the X(3872) mass lies less than 200 keV away from the D⁰D¯ ⁰* threshold, reenforcing its interpretation as a loosely bound mesonic molecule. This observation implies that in processes like D⁰D¯⁰ π⁰ production, threshold effects could disguise the actual pole position of the X(3872). We propose a new effective field theory with D⁰, D¯ ⁰, and π⁰ degrees of freedom for the X(3872), considering Galilean invariance to be an exact symmetry. The D⁰ enters as a D⁰π⁰ p-wave resonance, allowing for a comprehensive study of the influence of pion interactions on the Xð3872Þ width. We calculate relations between the mass of the X(3872), its width, and its line shape in D⁰D¯⁰ π⁰ production up to next-to-leading order. Our results provide a tool for the extraction of the X(3872) pole position from the experimental data near threshold.
title: De quelle manière sont représentés les divers éléments culturels dans les moyens d’enseignement romands d’allemand ?
title: De quelle manière sont représentés les divers éléments culturels dans les moyens d’enseignement romands d’allemand ?
titleType: AlternativeTitle
Creators: name: Leuzinger, Margaux
name: Leyvraz, Justine
Publisher: name: Unknown
Year: 0
Subjects: subject: langue-culture
subject: moyens d’enseignement romands (MER)
subject: Landeskunde
subject: Enseignement d’une langue L2 au primaire

description: Notre mémoire porte sur les diverses représentations de la culture dans les moyens d’enseignement romands d’allemand proposés au cycle 2. Le but de ce mémoire est de nous rendre compte des diverses représentations présentes et proposées aux élèves dans l’apprentissage de cette langue culture, ainsi que les diverses thématiques qui sont principalement abordées dans les moyens d’enseignement romands (MER). Notre question de recherche est la suivante : De quelle manière sont représentés les divers éléments culturels dans les moyens d’enseignement romands ? Dans un deuxième temps, et en guise de prolongement, nous pourrions imaginer mettre en lien ces représentations dans les MER1 avec celles propres aux enseignants. L’idée, ici, est de garder le concept de représentation comme fil rouge pour nos recherches. Ce qui nous intéresse c’est la manière dont sont présentés les éléments culturels dans les moyens d’enseignement romands. Pour ce faire, nous envisageons d’élaborer une liste de différents critères qui nous permettent d’analyser les moyens de manière précise et ainsi mettre en évidence la façon dont les éléments culturels sont représentés dans les degrés d’enseignement 5-6 Harmos.
The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)-results from the UK Sloane Project.
Creators: name: Shaaban, Abeer M
name: Hilton, Bridget
name: Clements, Karen
name: Dodwell, David
name: Sharma, Nisha
name: Kirwan, Cliona
name: Sawyer, Elinor
name: Maxwell, Anthony
name: Wallis, Matthew
name: Stobart, Hilary
name: Mylvaganam, Senthurun
name: Litherland, Janet
name: Brace-McDonnell, Samantha
name: Dulson-Cox, Joanne
name: Kearins, Olive
name: Provenzano, Elena
name: Ellis, Ian O
name: Pinder, Sarah E
name: Thompson, Alastair M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/67/1347
/631/67/2324
article

description: BACKGROUND: The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial. METHODS: We analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012 within the Sloane project. RESULTS: Microinvasion was recorded in 521 of 11,285 patients (4.6%), with considerable variation in reported incidence among screening units (0-25%). Microinvasion was associated with high-grade DCIS, larger DCIS size, comedo necrosis and solid, cribriform architecture (all P < 0.001). Microinvasion was more frequent in patients who underwent mastectomy compared with breast-conserving surgery (BCS) (6.9% vs 3.6%, P < 0.001), and in those undergoing axillary nodal surgery (60.4% vs 30.3%, P < 0.001) including the subset undergoing BCS (43.4% vs 8.5%, P < 0.001). Nodal metastasis rate was low and not statistically significant difference from the DCIS only group (P = 0.68). Following median follow-up of 110 months, 3% of patients had recurrent ipsilateral high-grade DCIS, and 4.2% developed invasive carcinoma. The subsequent ipsilateral invasion was of Grade 3 in 71.4% of patients with microinvasion vs 30.4% in DCIS without microinvasion (P = 0.02). Distant metastasis and breast cancer mortality were higher with microinvasion compared with DCIS only (1.2% vs 0.3%, P = 0.01 and 2.1% vs 0.8%; P = 0.005). CONCLUSIONS: The higher breast cancer mortality with microinvasion indicates a more aggressive disease.
title: Les interactions métacognitives dans l’enseignement de la résolution de problèmes mathématiques
title: Les interactions métacognitives dans l’enseignement de la résolution de problèmes mathématiques
titleType: AlternativeTitle
Creators: name: Sadiku, Lora
name: Kostic, Sanja
Publisher: name: Unknown
Year: 0
Subjects: subject: métacognition
subject: autorégulation
subject: cognition
subject: problèmes mathématiques
subject: interactions
subject: médiation

description: Ce mémoire professionnel s’intéresse aux interactions métacognitives permettant aux élèves d’acquérir une autorégulation dans leurs apprentissages. Nous nous intéressons plus précisément à la résolution de problèmes mathématiques dans le cadre de la numération. La pensée métacognitive est un outil important pour l’élève qu’il peut transférer dans d’autres disciplines et qui lui sera utile tout au long de son parcours scolaire. En tant qu’enseignantes, il est de notre devoir d’apporter les outils adéquats afin que l’élève utilise systématiquement ce questionnement métacognitif. Nous avons remarqué qu’il pouvait s’avérer difficile d’interagir avec les élèves sans forcément leur dire comment faire. Les interactions métacognitives permettent à l’élève de se questionner et d’ainsi appliquer cette démarche lorsqu’il se retrouvera seul face à une tâche. Le but est donc de montrer l’impact des médiations de l’enseignante et des pairs sur l’autorégulation des apprentissages. Pour cela, la récolte de données s’est faite dans nos deux classes de stage de 3H et 6H. Nous avons tout d’abord effectué un entretien avec nos PraFos, suivi d’observations en classe dans le but de récolter des informations sur l’utilisation de la démarche métacognitive en classe. Par la suite, nous avons mis en place un dispositif nous permettant d’interagir avec les élèves en collectif, en groupes et individuellement. Les démarches cognitives et métacognitives ont ainsi été utilisées pour permettre à l’élève d’avoir une prise de conscience de ses processus de pensée. En effet, l’un ne va pas sans l’autre, car il a été important d'expliciter les processus de pensée en jeu dans une tâche donnée afin d’avoir une réflexion dessus. Nous avons eu recours à divers outils comme le langage, la médiation ou encore l’étayage. Le questionnement sur les stratégies des élèves nous a permis d’observer la présence d’autorégulation ou non.
Dislocation Mechanics Pile-Up and Thermal Activation Roles in Metal Plasticity and Fracturing
Creators: name: Armstrong, Ronald W.
Publisher: name: MDPI
Year: 2019
Subjects: dislocation mechanics
yield strength
grain size
thermal activation
strain rate
impact tests
brittleness transition
fracturing
crack size
fracture mechanics

description: Dislocation pile-up and thermal activation influences on the deformation and fracturing behaviors of polycrystalline metals are briefly reviewed, as examples of dislocation mechanics applications to understanding mechanical properties. To start, a reciprocal square root of grain size dependence was demonstrated for historical hardness measurements reported for cartridge brass, in line with a similar Hall-Petch grain size characterization of stress-strain measurements made on conventional grain size and nano-polycrystalline copper, nickel, and aluminum materials. Additional influences of loading rate (and temperature) were shown to be included in a dislocation model thermal activation basis, for calculated deformation shapes of impacted solid cylinders of copper and Armco iron materials. Connection was established for such grain size, temperature, and strain rate influences on the brittle fracturing transition exhibited by steel and other related metals. Lastly, for AISI 1040 steel material, a fracture mechanics based failure stress dependence on the inverse square root of crack size was shown to approach the yield stress at a very small crack size, also in line with a Hall-Petch dependence of the stress intensity on polycrystal grain size.
Rapid Health Impact Assessment of a Proposed Poultry Processing Plant in Millsboro, Delaware
Creators: name: Baskin-Graves, Leah
name: Mullen, Haley
name: Aber, Aaron
name: Sinisterra, Jair
name: Ayub, Kamran
name: Amaya-Fuentes, Roxana
name: Wilson, Sacoby
Publisher: name: MDPI
Year: 2019
Subjects: health impact assessment
poultry processing plant
environmental justice

description: In 2013, Allen Harim Foods purchased the former site of a Vlasic Pickle plant in Millsboro, Delaware, and proposed to convert the site into a poultry processing plant that would process approximately two million birds weekly. This generated concerns about the proposed plant’s potential to impact health and quality of life among residents. We conducted a rapid health impact assessment (HIA) of the proposed plant to assess baseline environmental health issues in the host community and projected impacts. The scoping and baseline assessment revealed social, economic, and health disparities in the region. We also determined that residents in the area were already underserved and overburdened with pollution from multiple environmental hazards near the proposed plant including two sites contaminated with hazardous wastes, a power plant, and another poultry processing plant. The projected size and amount of poultry to be processed at the plant would likely cause increased levels of air, soil and water pollution, additional odor issues, and increased traffic and related pollution and safety issues. The information generated from the HIA formed the basis of a campaign to raise awareness about potential problems associated with the new facility and to foster more engagement of impacted residents in local decision-making about the proposed plant. In the end, the HIA helped concerned residents oppose the new poultry processing plant. This case study provides an example of how HIAs can be used as a tool to educate residents, raise awareness about environmental justice issues, and enhance meaningful engagement in local environmental decision-making processes.
Additional file 3 of NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel
Creators: name: Liu, Meng
name: Zhang, Su-Bo
name: Luo, Yu-Xuan
name: Yang, Yan-Ling
name: Zhang, Xiang-Zhong
name: Li, Bo
name: Meng, Yan
name: Chen, Yuan-Jie
name: Guo, Rui-Xian
name: Xiong, Yuan-Chang
name: Xin, Wen-Jun
name: Li, Dai
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Table S2. The specific primer sequences. (DOC 2 kb)
title: On coupled-channel dynamics in the presence of anomalous thresholds
Creators: name: Lutz, Matthias F. M.
name: Korpa, Csaba L.
Publisher: name: American Physical Society
Year: 2022

description: We explore a general framework to treat coupled-channel systems in the presence of overlapping left- and right-hand cuts as well as anomalous thresholds. Such systems are studied in terms of a generalized potential, where we exploit the known analytic structure of t- and u-channel forces as the exchange masses approach their physical values. Given an approximate generalized potential the coupled-channel reaction amplitudes are defined in terms of nonlinear systems of integral equations. For large exchange masses, where there are no anomalous thresholds present, conventional N=D methods are applicable to derive numerical solutions to the latter. At a formal level a generalization to the anomalous case is readily formulated by use of suitable contour integrations with amplitudes to be evaluated at complex energies. However, it is a considerable challenge to find numerical solutions to anomalous systems set up on a set of complex contours. By suitable deformations of left-hand and right-hand cut lines we manage to establish a framework of linear integral equations defined for real energies. Explicit expressions are derived for the driving terms that hold for an arbitrary number of channels. Our approach is illustrated in terms of schematic three-channel systems. It is demonstrated that despite the presence of anomalous thresholds the scattering amplitude can be represented in terms of three phase shifts and three inelasticity parameters, as one would expect from the coupled-channel unitarity condition.
Job Satisfaction of Public and Private Sectors of Manufacturing Industry in Lahore, Pakistan
Creators: name: Sardar, Stella
Publisher: name: Cardiff Metropolitan University
Year: 2022
Subjects: Industrial and employee relations

description: This study is conducted to investigate the statistical relationship between motivational factors (extrinsic/intrinsic) and job satisfaction of public and private-sector employees in the manufacturing industry of Lahore-Pakistan. Memon and Tahir (2012) stated that the manufacturing industry in Pakistan, which is one of the leading industries of the world, has shown decline in productivity in recent years. Various studies have shown that productivity improvement could be achieved when employees aresatisfied with their jobs as it has direct influence on the performance of organisations (Aziri, 2011). This thesis represents an original contribution of job satisfaction in the manufacturing industry of Lahore, Pakistan. In the last decade, Lahore hasmoved internationally to capture the global market. As a result, it is essential that it should concentrate on the employees of manufacturing industries in the region (Raza et al. 2015). However, due to increase in competition, some companies have failed to maintain their positions in the market. Hence, studies to date have provided some indication about how job satisfaction could be enhanced to the benefit of employees in these industries. However, although this subject area is a popular area in management studies, conclusions are frequently either inconclusive or conflicting. Using multiple regression analysis, research findings indicate that job security, supervision, working conditions, task significance, work environment, promotion, work itself, achievement, recognition and responsibility hold a statistically significant relationship with job satisfaction except for salaries and co-workers. The results obtained from the T-Test indicated that a statistical significant difference exists between the public and private-sector employees in the manufacturing industry of Lahore-Pakistan.The findings of this research, therefore, indicate that public sector employees are more satisfied with their jobs as compared to private sector employees. This study has implications for the public and private-sector entities and has opened a gateway for future researchers to explore further the variables which could enhance employee’s job satisfaction in the private sector of the manufacturing industry in Lahore-Pakistan.
Structure prediction of eukaryotic elongation factor-2 kinase and identification of the binding mechanisms of its inhibitors: homology modeling, molecular docking, and molecular dynamics simulation
Creators: name: Tatar, Gizem
name: Tok, Tugba Taskin
name: Ozpolat, Bulent
name: AY, Mehmet
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Protein kinases emerged as one of the most successful families of drug targets due to their increased activity and involvement in mediating critical signal transduction pathways in cancer cells. Recent evidence suggests that eukaryotic elongation factor 2 kinase (eEF-2K) is a potential therapeutic target for treating some highly aggressive solid cancers, including lung, pancreatic and triple-negative breast cancers. Thus, several compounds have been developed for the inhibition of the enzyme activity, but they are not sufficiently specific and potent. Besides, the crystal structure of this kinase remains unknown. Hence, the functional organization and regulation of eEF-2K remain poorly characterized. For this purpose, we constructed a homology model of eEF-2K and then used docking methodology to better understanding the binding mechanism of eEF-2K with 58 compounds that have been proposed as existing inhibitors. The results of this analysis were compared with the experimental results and the compounds effective against eEF-2K were determined against eEF-2K as a result of both studies. And finally, molecular dynamics (MD) simulations were performed for the stability of eEF-2K with these compounds. According to these study defined that the binding mechanism of eEF-2K with inhibitors at the molecular level and elucidated the residues of eEF-2K that play an important role in enzyme selectivity and ligand affinity. This information may lead to new selective and potential drug molecules to be for inhibition of eEF-2K. Communicated by Ramaswamy H. Sarma
A C-type lectin (AjSJL-1) containing DPN/WVD motifs in Apostichopus japonicus recognizes multiple microbes
Creators: name: Zhao, Q
name: Wang, H
name: Wang, W
name: Li, J
name: Liu, Y
name: Xue, Z
name: Liu, Z
name: Wang, L
name: Song, L
Publisher: name: Invertebrate Survival Journal
Year: 2021

description: C-type lectins (CTLs) are a superfamily of Ca2+ dependent carbohydrate-recognition proteins with diversified functions ranging from embryonic development to immune defense. In the present study, a CTL containing only one CRD domain with new motifs Asp-Pro-Asn (DPN) and Trp-Val-Asp (WVD) in its Ca2+ binding site 2 (designated as AjSJL-1) was identified from sea cucumber Apostichopus japonicus. The deduced amino acid sequence of AjSJL-1 was homologous to CTLs from other animals with the identities ranging from 19 % to 28.4 %. The mRNA transcripts of AjSJL-1 were detected in all the examined tissues with varied abundance. The expression level of AjSJL-1 mRNA in coelomocyte was up-regulated significantly at 12 h after Vibrio splendidus challenge. The recombinant protein of AjSJL-1 (rAjSJL-1) displayed significant binding activity to lipopolysaccharide, peptidoglycan, mannose and D-galactose in a Ca2+-dependent manner. Moreover, rAjSJL-1 exhibited strong binding capability to V. splendidus but week to Staphylococcus aureus, Bifidobacterium breve, Pichia pastoris and Yarrowia lipolytica in the presence of Ca2+. These results collectively suggested that AjSJL-1 with new DPN/WVD motifs served as a pattern recognition receptor in sea cucumber with the capability to bind broad-spectrum microbes and initiate the immune response against invaders.
description: Invertebrate Survival Journal, Vol 18 No 1 (2021)
title: Standing for Unči Maka (Grandmother Earth) and all Life: An Introduction to Lakota Traditional Sciences, Principles and Protocols and the Birth of a New Era of Scientific Collaboration
Creators: name: Mario Gonzalez (Nantan Hinapan)
name: Anpetu Luta Wiŋ (Antonia Loretta Afraid of Bear-Cook)
name: Yvette Running Horse Collin (Tašunke Iyanke Wiŋ)
name: Mažasu (Wendell W. Yellow Bull)
name: Sam High Crane (Wapageya Mani)
name: Barbara Dull Knife (Mapiya Ki Yake Wiŋ)
name: Mila Hunska Tašunke Icu (Joseph American Horse)
name: Tanka Omniya (Robert Milo Yellow Hair)
name: Wakinyala Wiŋ (Anita Afraid of Bear)
name: Bill Means
name: Akil Nujipi (Harold Left Heron)
Publisher: name: University of Colorado Boulder
Year: 2021

description: Lakota science and scientific systems were communally developed over thousands of years with sustainability, alignment and ecological balance as the goals. Lakota knowledge keepers, traditional leaders and scholars offer an introduction to Lakota scientific systems, principles and protocols to stimulate a much needed dialogue between Indigenous scientists and the mainstream scientific, economic and political communities. As is customary protocol-wise, the Lakota always follow Šungwakaŋ, the Horse Nation. Here, the Lakota provide narrative correction with regard to their relationship with Šungwakaŋ, their history, sciences, perspectives, scientific systems, and clarification regarding their sacred commitment to protect Unči Maka (Grandmother Earth) and all life. A case is made for the birthing of a new, truly collaborative era for Science that is based upon equality and mutual respect, fully embracing the contributions and concepts of unique scientific systems. With climate change upon us, the world can no longer afford to have Indigenous scientific systems suppressed or their voices actively ignored and silenced within science and academia. There is only one Earth, and she is calling out for us to come together for the protection of all life. Mitakuye Oyasiŋ.
NASA’s Early Adopter Program Links Satellite Data to Decision Making
Creators: name: Brown, Molly E.
name: Escobar, Vanessa M.
Publisher: name: MDPI
Year: 2019
Subjects: satellite missions
partnerships
NASA
early adopter
utilization
applications
decision support

description: As the cost of satellite missions grow, government agencies are working to increase the relevance and usefulness of the Earth science data that they produce. The US National Aeronautics and Space Administration’s (NASA) early adopter program seeks to formalize partnerships with users of data early within the satellite planning process to ensure the greatest value of the mission. Scientists who are designing the satellite observing system, those who are developing mission data products, and the community who will use them need to work together to determine how satellite data can better inform decision making. NASA is working to initiate engagement with data users much earlier in the satellite program life so that the user needs can be prioritized, continue to engage with users throughout the development cycle, and then include analysis on societal impact after nominal mission life. The Early Adopter Program allows for broad and early engagement with decision makers by encouraging individuals and institutions with clear uses of data to engage with the mission. Early adopters facilitate feedback on mission products during pre-launch and accelerate the utilization of these products post-launch. This paper provides background and detail on how NASA is working to engage with early adopters, describes the partnership between early adopters and NASA missions, and connects the program to improved societal impacts of its satellite missions.
Immunological and oxidative responses of the lesser mulberry pyralid, Glyphodes pyloalis by an aqueous extract of Artemisia annua L.
Creators: name: Afraze, Z
name: Sendi, J J
Publisher: name: Invertebrate Survival Journal
Year: 2021

description: In this search for affordable and locally available biological substances both to farmers and environment, an aqueous extract of Artemisia annua L. was investigated for the first time against the lesser mulberry pyralid, Glyphodes pyloalis Walker a serious pest in mulberry orchards. The LC10, LC30 and LC50 values were estimated 12.82 %, 20.6 % and 27.35 % (W/V) respectively. The extract adversely affected oviposition, impaired immunity through reduced granulocytes and phenoloxidase activity. The increased activity of detoxifying enzymes including esterases and glutathione S-transferase (GST) were also observed. The enhanced antioxidant system including peroxidase (POX), catalase (CAT), glucose 6-phosphate dehydrogenase (GPDH) and superoxide dismutase (SOD) were also observed. The results of the present study may provide a very safe way to control this pest in mulberry orchard and deserve further studies.
description: Invertebrate Survival Journal, Vol 18 No 1 (2021)
A Field-Friendly Loop-Mediated Isothermal Amplification (FF-LAMP) method for rapid detection of Nosema bombycis in silkworm, Bombyx mori
Creators: name: Sivaprasad, V
name: Satish, L
name: Mallikarjuna, G
name: Chandrakanth, N
name: Mary Josepha, A V
name: Moorthy, S M
Publisher: name: Invertebrate Survival Journal
Year: 2021

description: Pebrine is a destructive disease that exhibits horizontal and vertical transmission and therefore it is the only mandatory quarantine item in sericulture. Here, a field-friendly loop-mediated isothermal amplification (FF-LAMP) method has been developed and validated for the rapid detection of Nosema bombycis, a causative agent of pebrine disease in silkworm, Bombyx mori. FF-LAMP primers were selected and designed for small ribosomal subunit gene and the assay was performed to detect the N. bombycis infection in silkworm. The FF-LAMP reaction was effective at 6 mM MgSO4, 1.4 mM dNTPs at 63 °C. The detection range of LAMP assay was found to be 101 dilutions of N. bombycis spores. Specificity of the primers was tested using DNA isolated from pebrine infected silkworm, pebrine free silkworm and pure N. bombycis by conventional PCR and FF-LAMP assay. Results revealed that the primers were specific to N. bombycis DNA. The FF-LAMP assay was validated in different basic silkworm seed farms with simultaneous microscopic examination of N. bombycis infection. This newly developed method is highly effective, specific, sensitive and rapid in detecting N. bombycis infection, eliminating the DNA purification steps and usage of sophisticated equipment. This method can be used in testing large number of samples making it field friendly method in sericulture industry.
description: Invertebrate Survival Journal, Vol 18 No 1 (2021)
title: BucDoop: Bottom Up Computation of Iceberg Data Cubes
with Hadoop
Creators: name: Τσακωνας Κωνσταντινος
Publisher: name: Technical University of Crete
Year: 2014

description: Big Data analysis has been a key matter during the recent years for the study of various phenomena in various science contexts as well as in business intelligence. Furthermore it appears for good reason to remain in focus for the future. Online Analytical processing methods and Data Cubes need to be further studied in order to reduce time used for efficient data analysis. This study introduces BucDoop, a novel algorithm that exploits the parallelism benefits of Hadoop Map Reduce, for the efficient iceberg data cube creation in reasonable time. BucDoop includes the use of the Bottom Up Computation (BUC) idea in the context of iceberg cube data lattice traversal, managing to reduce the amount of data handled with early pruning architecture and producing the portion of the cube needed for analysis purposes (iceberg problem). Experiments conducted herein present an efficient scalability factor for the creation of the iceberg cube for very big data, by-passing the data explosion and memory constraints problem while using only commodity hardware.
title: Universal physics of bound states of a few charged particles
Creators: name: Schmickler, Christiane H.
name: Hammer, Hans-Werner
name: Volosniev, Artem G.
Publisher: name: Elsevier
Year: 2022

description: We study few-body bound states of charged particles subject to attractive zero-range/short-range plus repulsive Coulomb interparticle forces. The characteristic length scales of the system at zero energy are set by the Coulomb length scale D and the Coulomb-modified effective range reff. We study shallow bound states of charged particles with D >> reff and show that these systems obey universal scaling laws different from neutral particles. An accurate description of these states requires both the Coulombmodified scattering length and the effective range unless the Coulomb interaction is very weak (D → ∞). Our findings are relevant for bound states whose spatial extent is significantly larger than the range of the attractive potential. These states enjoy universality – their character is independent of the shape of the short-range potential.
Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level
Creators: name: Lin, Xingcheng
name: Kulkarni, Prakash
name: Bocci, Federico
name: Schafer, Nicholas P.
name: Roy, Susmita
name: Tsai, Min-Yeh
name: He, Yanan
name: Chen, Yihong
name: Rajagopalan, Krithika
name: Mooney, Steven M.
name: Zeng, Yu
name: Weninger, Keith
name: Grishaev, Alex
name: Onuchic, José N.
name: Levine, Herbert
name: Wolynes, Peter G.
name: Salgia, Ravi
name: Rangarajan, Govindan
name: Uversky, Vladimir
name: Orban, John
name: Jolly, Mohit Kumar
Publisher: name: MDPI
Year: 2019
Subjects: PAGE4
intrinsically disordered proteins
conformational plasiticity
order-disorder transition
phosphorylation

description: Folded proteins show a high degree of structural order and undergo (fairly constrained) collective motions related to their functions. On the other hand, intrinsically disordered proteins (IDPs), while lacking a well-defined three-dimensional structure, do exhibit some structural and dynamical ordering, but are less constrained in their motions than folded proteins. The larger structural plasticity of IDPs emphasizes the importance of entropically driven motions. Many IDPs undergo function-related disorder-to-order transitions driven by their interaction with specific binding partners. As experimental techniques become more sensitive and become better integrated with computational simulations, we are beginning to see how the modest structural ordering and large amplitude collective motions of IDPs endow them with an ability to mediate multiple interactions with different partners in the cell. To illustrate these points, here, we use Prostate-associated gene 4 (PAGE4), an IDP implicated in prostate cancer (PCa) as an example. We first review our previous efforts using molecular dynamics simulations based on atomistic AWSEM to study the conformational dynamics of PAGE4 and how its motions change in its different physiologically relevant phosphorylated forms. Our simulations quantitatively reproduced experimental observations and revealed how structural and dynamical ordering are encoded in the sequence of PAGE4 and can be modulated by different extents of phosphorylation by the kinases HIPK1 and CLK2. This ordering is reflected in changing populations of certain secondary structural elements as well as in the regularity of its collective motions. These ordered features are directly correlated with the functional interactions of WT-PAGE4, HIPK1-PAGE4 and CLK2-PAGE4 with the AP-1 signaling axis. These interactions give rise to repeated transitions between (high HIPK1-PAGE4, low CLK2-PAGE4) and (low HIPK1-PAGE4, high CLK2-PAGE4) cell phenotypes, which possess differing sensitivities to the standard PCa therapies, such as androgen deprivation therapy (ADT). We argue that, although the structural plasticity of an IDP is important in promoting promiscuous interactions, the modulation of the structural ordering is important for sculpting its interactions so as to rewire with agility biomolecular interaction networks with significant functional consequences.
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Creators: name: Kejzar, Nejc
name: Laanto, Elina
name: Rissanen, Ilona
name: Abrishami, Vahid
name: Selvaraj, Muniyandi
name: Moineau, Sylvain
name: Ravantti, Janne
name: Sundberg, Lotta-Riina
name: Huiskonen, Juha T
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/326/1321
/631/45/535/1258/1259
/631/326/596/2554
/101/28
/45
/45/23
article

description: The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate the study of distant evolutionary relationships. Here we characterize the lipid-containing ssDNA temperate bacteriophage ΦCjT23, which infects Flavobacterium sp. (Bacteroidetes). We report ΦCjT23-like sequences in the genome of strains belonging to several Flavobacterium species. The virion structure determined by cryogenic electron microscopy reveals similarities to members of the viral kingdom Bamfordvirae that currently consists solely of dsDNA viruses with a major capsid protein composed of two upright β-sandwiches. The minimalistic structure of ΦCjT23 suggests that this phage serves as a model for the last common ancestor between ssDNA and dsDNA viruses in the Bamfordvirae. Both ΦCjT23 and the related phage FLiP infect Flavobacterium species found in several environments, suggesting that these types of viruses have a global distribution and a shared evolutionary origin. Detailed comparisons to related, more complex viruses not only expand our knowledge about this group of viruses but also provide a rare glimpse into early virus evolution.
title: Ανάπτυξη παράλληλου συστήματος για εξαγωγή υπογράφων
title: Development of highly parallel system for frequent subgraph mining
Creators: name: Μαντακος Γεωργιος
Publisher: name: Technical University of Crete
Year: 2014

description: Η εξόρυξη πληροφορίας από δεδομένα αποθηκευμένα σε μορφή γράφων (graph mining) βρίσκει πρακτική εφαρμογή σε πολλές περιοχές (molecular substructure discovery, web link analysis, fraud detection, social network analysis). Καθώς αυξάνεται ο όγκος των δεδομένων αυτών, ενώ συσσωρεύεται συνεχώς καινούργια πληροφορία, αυξάνεται μαζί του και η ανάγκη για αποδοτικότερη και γρηγορότερη εξόρυξη.
Το πρόβλημα που έχουν να λύσουν αυτοί οι αλγόριθμοι συνοψίζεται στην εξεύρεση όλων των υπογράφων που εμφανίζονται σε τουλάχιστον s γράφους σε ένα σύνολο γράφων (dataset), όπου το s καθορίζεται από το χρήστη. Ο έλεγχος ισομορφισμού των γράφων και ο τεράστιος χώρος αναζήτησης (search space) των υποφήφιων μοτίβων των γράφων (graph patterns) κάνουν τη διαδικασία χρονοβόρα ακόμη και για μικρά dataset. Για αυτό το λόγο έχουν γίνει αρκετές δουλειές πάνω σε παράλληλες υλοποιήσεις αυτών των αλγόριθμων σε διάφορες αρχιτεκτονικές.
Στην παρούσα εργασία γίνεται μια προσπάθεια παραλληλοποίησης σε GPU ενός από τους πιο αποδοτικούς αλγόριθμους στο πεδίο του frequent subgraph mining, του gSpan (Graph-Based Substructure Pattern Mining).
title: Erratum: Thermal quarkonium mass shift from Euclidean correlators
Creators: name: Eller, Alexander M.
name: Ghiglieri, Jacopo
name: Moore, Guy D.
Publisher: name: American Physical Society
Year: 2022

description: A further investigation let us realize that the object we are calculating is not a thermal quarkonium mass shift, but the fluctuation counterpart to the momentum diffusion (dissipative) coefficient of a single heavy quark κ.
The influence of age, growth and maturation upon maximal sprint speed in male youth
Creators: name: Meyers, Rob
Publisher: name: Cardiff Metropolitan University
Year: 2022
Subjects: Sports science and exercise not elsewhere classified

description: The literature pertaining to the development of maximal sprint performance in male youth is sparse. Existing literature suffers from a combination of small sample sizes, a lack of control for the influence of maturity, methodological approaches where maximal speed is not measured or failure to explore the spatiotemporal, kinematic or kinetic characteristics associated with sprint performance in male youth. On this basis, the aim of this thesis was to investigate the influence of growth and maturation upon maximal overground sprint performance in a large cohort of 11-16 year old boys. Sprint and spatiotemporal variables were found to have acceptable reliability (CV = 3.8-12.6%). Cross-sectional analysis of a large sample of boys showed a maturational effect on sprint performance, with the period of peak height velocity (PHV) eliciting the greatest enhancements in maximal sprint speed. Furthermore, whilst improvements in step length (SL) were observed with increasing maturity, step frequency (SF) was largely stable, with some evidence of small declines during the pre-PHV period. Further cross-sectional analysis revealed that pre-PHV boys were SF-reliant during maximal sprint performance, whilst post-PHV boys were deemed SL-reliant. Analysis of body size revealed that stature had a positive influence upon maximal sprint performance, whilst mass had a negative influence. Cross-sectional analysis of the kinetic characteristics of maximal sprint performance revealed that both relative maximal force and relative vertical stiffness did not increase with advancing age and maturity, but these variables were deemed to be the most important predictors of maximal sprint performance in male youth, independent of age and maturity. Furthermore, longitudinal analysis confirmed that relative force production and relative vertical stiffness were the most important predictors of maximal sprint performance in boys, and that those who had passed the period of PHV experienced greater gains in maximal speed than those who remained pre-PHV. Collectively the results of the empirical studies highlight that maximal sprint speed in male youth develops with advancing age and maturation, due to an interaction of changes in SL and SF. These changes are partly related to changes in body size and the period of PHV appears to be a key period during the development of maximal speed. However, there are also key predictors of speed, such as relative force and relative vertical stiffness that do not change between the ages of 11 and 16 years old.
Additional file 1 of Lower serum nicotinamide N-methyltransferase levels in patients with bipolar disorder during acute episodes compared to healthy controls: a cross-sectional study
Creators: name: Hu, Qing
name: Liu, Farong
name: Yang, Luyin
name: Fang, Zanxi
name: He, Jue
name: Wang, Wenqiang
name: You, Pan
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 1: Table S1. History of psychotropic medication in patients with recurrent bipolar mania and expression levels of serum NNMT between groups.
Strategic business decisions of retailers in the edible insect value chain in Uganda
Creators: name: Donkor, Emmanuel
name: Mbeche, Robert
name: Mithöfer, Dagmar
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: edible insects
subject: market development
subject: strategic business decisions
subject: supply chain management
subject: traditional food retailing
subject: procurement strategy
subject: 630 Landwirtschaft und verwandte Bereiche

description: This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: Edible insect value chains are expected to contribute to sustainable food and nutrition security, poverty alleviation and job creation in Sub-Saharan Africa. However, there is little empirical evidence on the strategic business decisions of midstream-actors in edible insect value chain. This study fills this knowledge gap by analysing the factors that influence retailers’ strategic business decisions, that is, choices of supplier, product to purchase, procurement strategy and the quantity of product purchased in the grasshopper value chain in central Uganda. Using a primary dataset collected from 500 randomly selected retailers from two districts in central Uganda, Cragg’s tobit alternative and binary probit models are applied in the empirical analysis. Retailers mainly procure grasshopper products from wholesalers and collectors. The study shows that demographic, economic, transactional and processing-related factors significantly influence retailers’ strategic business decisions in the grasshopper markets. Developing retailers’ human capital in business management practices and collective action is important to enable them to make informed strategic business decisions in the agrifood chain.
Towards Inquiry-Based Learning in Spatial Development and Heritage Conservation: A Workshop at Corviale, Rome
Creators: name: Caudo, Giovanni
name: Fava, Federica
name: Oevermann, Heike
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: community-based practices
subject: heritage
subject: sets-of-knowledge
subject: public housing
subject: inquiry-based learning
subject: 550 Geowissenschaften

description: This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: Situated local knowledge and co-evolutionary processes overtake certitude and formal planning, challenging the way (cultural) heritage is produced in terms of both space and knowledge. This article contributes to the debate surrounding planning education and research by exploring the potential of inquiry-based learning (IBL) in spatial development and heritage conservation. The main argument is that the IBL format presented herein enables interaction and cooperation between various groups and their diverse sets of knowledge. To that end, the IBL approach was implemented both through project work and by creating a specific learning environment encompassing theory, exhibition, places, and people, and in which a research process was realised by students through iteration and reflection. The contribution systematises the results of a 2021 workshop held in Venice and Rome, including at the Corviale housing complex (Rome). In seeking to respond to the title-theme of the Venice Biennale, How will we live together?, initial evidence shows that educational activities stemming from clear research questions and “embedded” ways of inquiry-based learning present remarkable opportunities for participants to improve their ability to navigate into fragile and uncertain futures of the territory, engaging students in a wider process of knowledge-building.