cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ultraviolet astronomical spectrograph calibration with laser frequency combs from nanophotonic lithium niobate waveguides
Creators: name: Ludwig, Markus
name: Ayhan, Furkan
name: Schmidt, Tobias M.
name: Wildi, Thibault
name: Voumard, Thibault
name: Blum, Roman
name: Ye, Zhichao
name: Lei, Fuchuan
name: Wildi, François
name: Pepe, Francesco
name: Gaafar, Mahmoud A.
name: Obrzud, Ewelina
name: Grassani, Davide
name: Hefti, Olivia
name: Karlen, Sylvain
name: Lecomte, Steve
name: Moreau, François
name: Chazelas, Bruno
name: Sottile, Rico
name: Torres-Company, Victor
name: Brasch, Victor
name: Villanueva, Luis G.
name: Bouchy, François
name: Herr, Tobias
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Astronomical precision spectroscopy underpins searches for life beyond Earth, direct observation of the expanding Universe and constraining the potential variability of physical constants across cosmological scales. Laser frequency combs can provide the critically required accurate and precise calibration to the astronomical spectrographs. For cosmological studies, extending the calibration with such astrocombs to the ultraviolet spectral range is highly desirable, however, strong material dispersion and large spectral separation from the established infrared laser oscillators have made this exceedingly challenging. Here, we demonstrate for the first time astronomical spectrograph calibrations with an astrocomb in the ultraviolet spectral range below 400 nm. This is accomplished via chip-integrated highly nonlinear photonics in periodically-poled, nano-fabricated lithium niobate waveguides in conjunction with a robust infrared electro-optic comb generator, as well as a chip-integrated microresonator comb. These results demonstrate a viable route towards astronomical precision spectroscopy in the ultraviolet and may contribute to unlocking the full potential of next generation ground- and future space-based astronomical instruments.
MOESM5 of Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial
Creators: name: Demiselle, Julien
name: Wepler, Martin
name: Hartmann, Clair
name: Radermacher, Peter
name: Schortgen, Frédérique
name: Meziani, Ferhat
name: Singer, Mervyn
name: Seegers, Valérie
name: Asfar, Pierre
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Neuroscience
Developmental Biology

description: Additional file 5: Table S4. Infectious events during the ICU stay of patients according to lactate level (≤ 2 or > 2 mmol/L) and normoxia or hyperoxia treatment.
Precise measurement of $R_{\text{uds}}$ and $R$ between 1.84 and 3.72 GeV at the KEDR detector
Creators: name: Anashin, V. V.
name: Anchugov, O. V.
name: Aulchenko, V. M.
name: Baldin, E. M.
name: Baranov, G. N.
name: Barladyan, A. K.
name: Barnyakov, A. Yu.
name: Barnyakov, M. Yu.
name: Baru, S. E.
name: Basok, I. Yu.
name: Batrakov, A. M.
name: Bekhtenev, E. A.
name: Blinov, A. E.
name: Blinov, V. E.
name: Bobrov, A. V.
name: Bobrovnikov, V. S.
name: Bogomyagkov, A. V.
name: Bondar, A. E.
name: Buzykaev, A. R.
name: Cheblakov, P. B.
name: Dorohov, V. L.
name: Eidelman, S. I.
name: Grigoriev, D. N.
name: Glukhov, S. A.
name: Kaminskiy, V. V.
name: Karnaev, S. E.
name: Karpov, G. V.
name: Karpov, S. V.
name: Karukina, K. Yu.
name: Kashtankin, D. P.
name: Kasyanenko, P. V.
name: Kharlamova, T. A.
name: Kiselev, V. A.
name: Kolmogorov, V. V.
name: Kononov, S. A.
name: Kotov, K. Yu.
name: Krasnov, A. A.
name: Kravchenko, E. A.
name: Kudryavtsev, V. N.
name: Kulikov, V. F.
name: Kurkin, G. Ya.
name: Kuyanov, I. A.
name: Levichev, E. B.
name: Maksimov, D. A.
name: Malyshev, V. M.
name: Maslennikov, A. L.
name: Meshkov, O. I.
name: Mishnev, S. I.
name: Morozov, I. A.
name: Morozov, I. I.
name: Nikitin, S. A.
name: Nikolaev, I. B.
name: Okunev, I. N.
name: Onuchin, A. P.
name: Oreshkin, S. B.
name: Osipov, A. A.
name: Ovtin, I. V.
name: Peleganchuk, S. V.
name: Pivovarov, S. G.
name: Piminov, P. A.
name: Petrov, V. V.
name: Prisekin, V. G.
name: Rezanova, O. L.
name: Ruban, A. A.
name: Savinov, G. A.
name: Shamov, A. G.
name: Shatilov, D. N.
name: Shvedov, D. A.
name: Shwartz, B. A.
name: Simonov, E. A.
name: Sinyatkin, S. V.
name: Skrinsky, A. N.
name: Sokolov, A. V.
name: Sukhanov, D. P.
name: Sukharev, A. M.
name: Starostina, E. V.
name: Talyshev, A. A.
name: Tayursky, V. A.
name: Telnov, V. I.
name: Tikhonov, Yu. A.
name: Todyshev, K. Yu.
name: Tribendis, A. G.
name: Tumaikin, G. M.
name: Usov, Yu. V.
name: Vorobiov, A. I.
name: Zhilich, V. N.
name: Zhukov, A. A.
name: Zhulanov, V. V.
name: Zhuravlev, A. N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The present work continues a series of the KEDR measurements of the $R$ value that started in 2010 at the VEPP-4M $e^+e^-$ collider. By combining new data with our previous results in this energy range we measured the values of $R_{\text{uds}}$ and $R$ at nine center-of-mass energies between 3.08 and 3.72 GeV. The total accuracy is about or better than $2.6\%$ at most of energy points with a systematic uncertainty of about $1.9\%$. Together with the previous precise $R$ measurement at KEDR in the energy range 1.84-3.05 GeV, it constitutes the most detailed high-precision $R$ measurement near the charmonium production threshold.
description: arXiv admin note: text overlap with arXiv:1610.02827 and substantial text overlap with arXiv:1510.02667
Dynamics of supernova bounce in laboratory
Creators: name: Blinnikov, S. I.
name: Ilkaev, R. I.
name: Mochalov, M. A.
name: Mikhailov, A. L.
name: Iosilevskiy, I. L.
name: Yudin, A. V.
name: Glazyrin, S. I.
name: Golubev, A. A.
name: Gryaznov, V. K.
name: Fortova, S. V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We draw attention to recent high explosive (HE) experiments which provide compression of macroscopic amount of matter to high, even record, values of pressure in comparison with other HE experiments. The observed bounce after the compression corresponds to processes in core-collapse supernova explosions after neutrino trapping. Conditions provided in the experiments resemble those in core-collapse supernovae, permitting their use for laboratory astrophysics. A unique feature of the experiments is compression at low entropy. The values of specific entropy are close to those obtained in numerical simulations during the process of collapse in supernova explosions, and much lower than those obtained at laser ignition facilities, another type of high-compression experiment. Both in supernovae and HE experiments the bounce occurs at low entropy, so the HE experiments provide a new platform to realize some supernova collapse effects in laboratory, especially to study hydrodynamics of collapsing flows and the bounce. Due to the good resolution of diagnostics in the compression of macroscopic amounts of material with essential effects of nonideal plasma in EOS, and observed development of 3D instabilities, these experiments may serve as a useful benchmark for astrophysical hydrodynamic codes.
description: 13 pages, 8 figures, published in Phys.Rev.E, some typos corrected
$T\bar{T}$ Partition Function from Topological Gravity
Creators: name: Dubovsky, Sergei
name: Gorbenko, Victor
name: Hernandez-Chifflet, Guzman
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The $T{\bar T}$ deformation of a relativistic two-dimensional theory results in a solvable gravitational theory. Deformed scattering amplitudes can be obtained from coupling the undeformed theory to the flat space Jackiw--Teitelboim (JT) gravity. We show that the JT description is applicable and useful also in finite volume. Namely, we calculate the torus partition function of an arbitrary matter theory coupled to the JT gravity, formulated in the first order (vierbein) formalism. The first order description provides a natural set of dynamical clocks and rods for this theory, analogous to the target space coordinates in string theory. These dynamical coordinates play the role of relational observables allowing to define a torus path integral for the JT gravity. The resulting partition function is one-loop exact and reproduces the $T\bar{T}$ deformed finite volume spectrum.
description: 21 pages, 1 figure; v2: typos fixed and some notation clarified, as compared to the JHEP version
Physical Bias of Galaxies From Large-Scale Hydrodynamic Simulations
Creators: name: Cen, Renyue
name: Ostriker, Jeremiah P.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyze a new large-scale ($100h^{-1}$Mpc) numerical hydrodynamic simulation of the popular $Λ$CDM cosmological model, including in our treatment dark matter, gas and star-formation, on the basis of standard physical processes. The method, applied with a numerical resolution of $<200h^{-1}$kpc (which is still quite coarse for following individual galaxies, especially in dense regions), attempts to estimate where and when galaxies form. We then compare the smoothed galaxy distribution with the smoothed mass distribution to determine the "bias" defined as $b\equiv (δM/M)_{gal}/(δM/M)_{total}$ on scales large compared with the code numerical resolution (on the basis of resolution tests given in the appendix of this paper). We find that (holding all variables constant except the quoted one) bias increases with decreasing scale, with increasing galactic age or metallicity and with increasing redshift of observations. At the $8h^{-1}$Mpc fiducial comoving scale bias (for bright regions) is 1.35 at $z=0$ reaching to 3.6 at $z=3$, both numbers being consistent with extant observations. We also find that $(10-20)h^{-1}$Mpc voids in the distribution of luminous objects are as observed (i.e., observed voids are not an argument against CDM-like models) and finally that the younger systems should show a colder Hubble flow than do the early type galaxies (a testable proposition). Surprisingly, little evolution is found in the amplitude of the smoothed galaxy-galaxy correlation function (as a function of {\it comoving} separation). Testing this prediction vs observations will allow a comparison between this work and that of Kauffmann et al which is based on a different physical modelingmethod.
description: in press, ApJ, 26 latex pages plus 7 figs
Evidence for the existence of a novel class of supersymmetric black holes with AdS$_5\times$S$^5$ asymptotics
Creators: name: Markeviciute, Julija
name: Santos, Jorge E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct a new class of charged, rotating hairy black holes in a consistent truncation of $\mathcal{N} = 8$ supergravity, which retains one charged scalar field and a U$(1)$ gauge field. These hairy solutions can be uplifted to solutions of type IIB supergravity with AdS$_5\times$S$^5$ asymptotics. We find rotating hairy black holes with finite entropy arbitrarily close to the supersymmetric bound - the resulting supersymmetric solution is a one-parameter extension of the Gutowski-Reall solution. These solutions have finite curvature invariants (including at extremality), but in the extremal limit exhibit diverging tidal forces in the near horizon region. Nevertheless, we argue that these limiting supersymmetric black holes can be consistently studied within the supergravity approximation.
description: 13 pages, 3 figures
title: ADCO, Abbaye de Cîteaux, Tablettes de cire, comptes du boursier, 1321-1325, 11 H 1165, f. 0005264
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Abbaye de Cîteaux, Tablettes de cire, comptes du boursier, 1321-1325, Archives départementales de la Côte-d'Or, 11 H 1165, f. 0005264, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Abbaye de Cîteaux, Tablettes de cire, comptes du boursier, 1321-1325, Archives départementales de la Côte-d'Or, 11 H 1165, f. 0005264, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Rock River, Wyo Showing Lincoln Highway Portion of Road to McFadden-Oilfield
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: subject: Maps
subject: Wyoming
subject: Albany County
subject: Laramie

description: The exact date of this map is unknown; the maps in this collection were made in the 1950s and 1960s.
GPU-Native Adaptive Mesh Refinement with Application to Lattice Boltzmann Simulations
Creators: name: Jaber, Khodr
name: Essel, Ebenezer
name: Sullivan, Pierre
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Adaptive Mesh Refinement (AMR) enables efficient computation of flows by providing high resolution in critical regions while allowing for coarsening in areas where fine detail is unnecessary. While early AMR software packages relied solely on CPU parallelization, the widespread adoption of heterogeneous computing systems has led to GPU-accelerated implementations. In these hybrid approaches, simulation data typically resides on the GPU, and mesh management and adaptation occur exclusively on the CPU, necessitating frequent data transfers between them. A more efficient strategy is to adapt and maintain the entire mesh structure exclusively on the GPU, eliminating these transfers. Because of its inherent parallelism, the Lattice Boltzmann Method (LBM) has been widely implemented in hybrid AMR frameworks. This work presents a GPU-native algorithm for AMR using a block-based forest of octrees approach, implemented in both two and three dimensions as open-source C++/CUDA code. The implementation includes a Lattice Boltzmann solver for weakly compressible flow, though the underlying grid refinement procedure is compatible with any solver operating on cell-centered block-based grids. The lid-driven cavity and flow past a square cylinder benchmarks validate the algorithm's effectiveness across multiple velocity sets in both single- and double-precision. Tests conducted on consumer and datacenter-grade GPUs demonstrate its versatility across different hardware platforms.
 Link to repository: https://github.com/KhodrJ/AGAL
description: 45 pages, 27 figures, 11 tables, postprint
Trochilus pella Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Apodiformes
Trochilidae
Trochilus
Trochilus pella

description: Trochilus pella [spec. nov.]
T. curvirostris, rectricibus intermediis longissimis, corpore rubro, capite fusco, gula aurata uropygioque viridi.
Mellivora major rubra, cauda longa. Edw. av. 32. t. 32. f. 2.
Habitat in Indiis.
Trochili aviculae minimae; aliae rostro recurvo, aliae incurvo, aliae rectto.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 119, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Early Universe hypercharge breaking and neutrino mass generation
Creators: name: López-Zurdo, Sergio
name: Lozano-Onrubia, Álvaro
name: Merlo, Luca
name: No, José Miguel
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that the conditions allowing for a spontaneous breaking of the $U(1)_Y$ hypercharge gauge symmetry of the Standard Model (SM) in the early Universe are generically present in extensions of the SM addressing the generation of light neutrino masses via radiative contributions. In such scenarios, the breaking of (hyper)charge at high-temperatures yields new possibilities for explaining the observed matter-antimatter asymmetry of the Universe. Considering for concreteness the Zee-Babu radiative neutrino mass generation model, we show that a period of hypercharge breaking prior to the electroweak phase transition could allow for successful baryogenesis via a non-conventional leptogenesis mechanism, based on the presence of charge-breaking masses for the SM leptons in the early Universe.
description: 11 pages, 5 figures. V2: version accepted for publication on PRL
Correlation Functions of the APM Clusters of Galaxies
Creators: name: Park, Changbom
name: Lee, Sungho
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have found that the two-point correlation function of the APM clusters of galaxies has an amplitude much higher than that claimed by the APM group. As the richness limit increases from R = 53 to 80, the correlation length increases from 17.5 to 28.9 h^{-1}Mpc. This indicates that the richness dependence of the APM cluster correlation function is also much stronger than what the APM group has reported. The richness dependence can be represented by a fitting formula r_0 = 0.53 d_c + 0.01, which is consistent with the Bahcall's formula r_0 = 0.4 d_c. We have tried to find the possible reason for discrepancies. However, our estimates for the APM cluster correlation function are found to be robust against variation of the method of calculation and of sample definition.
description: 6 pages, 4 postscript figures, uses kaspp.sty, submitted to Journal of the Korean Astronomical Society
MOESM4 of Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial
Creators: name: Demiselle, Julien
name: Wepler, Martin
name: Hartmann, Clair
name: Radermacher, Peter
name: Schortgen, Frédérique
name: Meziani, Ferhat
name: Singer, Mervyn
name: Seegers, Valérie
name: Asfar, Pierre
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Neuroscience

description: Additional file 4: Table S3. Daily evolution of the SOFA score’s components of patients according to lactate level (≤ 2 or > 2 mmol/L) and normoxia or hyperoxia treatment.
Multiplicative relations among differences of singular moduli
Creators: name: Aslanyan, Vahagn
name: Eterović, Sebastian
name: Fowler, Guy
Publisher: name: arXiv
Year: 2023
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Let $n \in \mathbb{Z}_{>0}$. We prove that there exist a finite set $V$ and finitely many algebraic curves $T_1, \ldots, T_k$ with the following property: if $(x_1, \ldots, x_n, y)$ is an $(n+1)$-tuple of pairwise distinct singular moduli such that $\prod_{i=1}^n (x_i - y)^{a_i}=1$ for some $a_1, \ldots, a_n \in \mathbb{Z} \setminus \{0\}$, then $(x_1, \ldots, x_n, y) \in V \cup T_1 \cup \ldots \cup T_k$. Further, the curves $T_1, \ldots, T_k$ may be determined explicitly for a given $n$.
description: 39 pages, to appear in Ann. Sc. Norm. Super. Pisa Cl. Sci
Trochilus polytmus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Apodiformes
Trochilidae
Trochilus
Trochilus polytmus

description: Trochilus polytmus [spec. nov.]
T. curvirostris, rectricibus lateralibus longissimis, corpore virescente, pileo rectricibusque fuscis.
Polytmus viridans aureo varie splendens, pinnis binis uropygii longissimis. Brown. jam. 475.
Mellivora capite nigro, cauda longa. Edw. av. 34. t. 34. Alb. av. 3. p. 45. t. 49. f. 1?
Mellivora avis maxima. Sloan. jam. 2. p. 309. t. 264. f. 4.
Habitat in America.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 120, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Reply to "Comment on 'Gravitational Pair Production and Black Hole Evaporation'"
Creators: name: Wondrak, Michael F.
name: van Suijlekom, Walter D.
name: Falcke, Heino
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In a recent letter, the authors presented a unified derivation of the electric Schwinger effect and a generalized Hawking effect with an additional radiation component. The approach discloses a radial profile of black hole pair production and traces the emission back to local tidal forces which are independent of the black hole event horizon. It uses an effective action valid to second order in curvature and arbitrary order in proper time. A comment on the letter supposed two inconsistencies when applying the central formula to the Schwinger effect in the presence of magnetic fields. The present letter points out that the partially flawed argumentation does not cast doubt on the results.
description: 2 pages. Version accepted for publication by Physical Review Letters. This version (v2) replies to the published version of the comment (Phys. Rev. Lett. 133 (2024) 229001)
Additional file 1 of Effectiveness of the mHealth intervention ‘MyDayPlan’ to increase physical activity: an aggregated single case approach
Creators: name: Degroote, L.
name: De Paepe, A.
name: De Bourdeaudhuij, I.
name: Van Dyck, D.
name: Crombez, G.
Publisher: name: figshare
Year: 2021
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Additional file 1.
Leveraging Medical Knowledge Graphs Into Large Language Models for Diagnosis Prediction: Design and Application Study
Creators: name: Gao, Yanjun
name: Li, Ruizhe
name: Croxford, Emma
name: Caskey, John
name: Patterson, Brian W
name: Churpek, Matthew
name: Miller, Timothy
name: Dligach, Dmitriy
name: Afshar, Majid
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare providers, risking diagnostic inaccuracies. While Large Language Models (LLMs) have showcased their potential in diverse language tasks, their application in the healthcare arena needs to ensure the minimization of diagnostic errors and the prevention of patient harm. In this paper, we outline an innovative approach for augmenting the proficiency of LLMs in the realm of automated diagnosis generation, achieved through the incorporation of a medical knowledge graph (KG) and a novel graph model: Dr.Knows, inspired by the clinical diagnostic reasoning process. We derive the KG from the National Library of Medicine's Unified Medical Language System (UMLS), a robust repository of biomedical knowledge. Our method negates the need for pre-training and instead leverages the KG as an auxiliary instrument aiding in the interpretation and summarization of complex medical concepts. Using real-world hospital datasets, our experimental results demonstrate that the proposed approach of combining LLMs with KG has the potential to improve the accuracy of automated diagnosis generation. More importantly, our approach offers an explainable diagnostic pathway, edging us closer to the realization of AI-augmented diagnostic decision support systems.
description: Published in JMIR AI
Chemical tools for probing protein N-myristoylation in protozoan parasites
Creators: name: Wright, Megan Holly
Publisher: name: Imperial College London
Year: 2013

description: Protein N -myristoylation is the attachment of a 14-carbon fatty acid, myristate, onto the N-terminal residue of specific proteins. This co - and post-translational modification is catalysed by myristoyl CoA:protein N -myristoyltransferase (NMT), an essential enzyme in eukaryotes. N -Myristoylated proteins have diverse roles, but typically localise to cellular membranes where many are thought to be involved in signalling or trafficking processes. NMT is a potential therapeutic target in diseases caused by parasitic protozoa, such as malaria, leishmaniasis and African sleeping sickness. N -Myristoylation is difficult to study by conventional biochemical methods. Recently chemical proteomics has emerged as a powerful technique for probing protein lipidation. In this approach chemically tagged myristic acid substrate analogues are incorporated metabolically into lipidated pro teins. Tagged proteins can then be selectively ‘captured’ after cell lysis via a bioorthogonal ligation reaction to install a variety of labels for further analysis. This thesis describes the development of such an approach for profiling protein lipidation in diverse systems, including human cells, Plasmodium , Leishmania and T. brucei parasites. This work includes the the synthesis of multifunctional probes for the capture of tagged proteins and characterisation of a tagged myristate analogue as a Plasmodium NMT substrate. These tools are applied in several contexts, with analysis by a combination of gel-based methods and mass spectrometry. The first de novo identification of N -myristoylated proteins in P. falciparum , T. brucei and L. donovani is described. The chemical proteomic methodology developed is also used to profile lipidation in the presence of putative NMT inhibitors to assess whether compounds act on -target in live parasites. The correlation between efficacy against the cell and on-target activity is analysed to explore NMT as a potential drug target in malaria and leishmaniasis.
Concepts in CMB Anisotropy Formation
Creators: name: Hu, Wayne
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: These lecture notes form a primer on the theory of cosmic microwave background (CMB) anisotropy formation. With emphasis on conceptual aspects rather than technical issues, we examine the physical foundations of anisotropy evolution in relativistic kinetic and perturbation theory as well as the manifestation of these principles in primary and secondary anisotropies. We discuss gauge choice and gauge invariance and their use in understanding the CMB. Acoustic, gravitational redshift and ionization effects have robust signatures in the CMB spectrum and may allow determination of classical cosmological parameters as well as reveal general distinctions between models for structure formation. We develop the tight and weak coupling approximations as analytic tools to help understand these effects and the robustness of their signatures.
description: 34 pgs, TeX + 11 uuencoded figures, also available at ftp://ftp.sns.ias.edu/pub/hu/concepts, to appear in ``The Universe at High-z, Large Scale Structure and the Cosmic Microwave Background'', eds. E. Martinez-Gonzalez & J.L Sanz (Springer Verlag)
A Dirac fermion model associated with second order topological insulator
Creators: name: Fukui, T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study topological aspects of a Dirac fermion coupled with a Higgs field associated with the lattice model introduced by Benalcazar et al. which shows the topological quadrupole phase. Using the index theorem, we show that the index of the Hamiltonian is just given by the winding number of the Higgs field, implying that a corner state of the lattice model belongs to the same class of the Jackiw-Rossi states localized at a vortex. We also calculate the current density of the Dirac fermion with a symmetry breaking term dependent on time, which is associated with the dipole pump proposed by Benalcazar et al. We argue that it is indeed a topological current, and the total pumped charge is given by an integer related with the index.
description: 12 pages, 5 figures. Text revised. Figures and appendix added
Peptidomimetic approach to the inhibition of N-myristoyltransferase, a promising parasitic drug target
Creators: name: Olaleye, Tayo
Publisher: name: Imperial College London
Year: 2012

description: N-myristoyltransferase (NMT), a ubiquitous enzyme, found in a number of organisms including fungi, parasites and humans, catalyses the irreversible transfer of a C-14 chain (myristic acid) to the N-terminal glycine of specific target proteins, a process known as N-myristoylation. NMT has been reported to be essential for the viability of parasites such as Trypanosoma brucei and Leishmania donovani which are responsible for the diseases African sleeping sickness and Leishmaniasis respectively. This suggests that NMT is a promising target for antiparasitic drug development. The work detailed in this thesis describes the use of a piggy-back approach in the design and synthesis of peptidomimetic NMT inhibitors derived from lead compounds originally reported as antifungal NMT inhibitors. NMT, in this report, is explored as a target for the study of malaria and leishmaniasis which are caused by Plasmodium and Leishmania respectively. The current therapeutic treatments of these two diseases, the role of N-myristoylation in the parasitic organisms will be discussed; this thesis will also detail the ligand- and structure-based synthesis of NMT inhibitors using solid phase peptide synthesis. The synthesised inhibitors were tested against P. vivax (PvNMT), P.falciparum (PfNMT), L. donovani (LdNMT) and human enzyme Homo sapiens NMT1 (HsNMT1) using a fluorogenic assay to generate an expansive structure-activity relationship (SAR). A structure- guided methodology using structural information from high resolution crystal structures in both Plasmodium and Leishmania was also employed to rationally design inhibitors. L.majorNMT (LmNMT) was used, for the first time, in a fragment-based screen and 9 hits were attained. Crystal structures of four of the fragments in the library were successfully generated in LmNMT. This work led to the discovery of potent peptidomimetic inhibitors of P. vivax NMT and L. donovani which were design ed from antifungal inhibitors, thus validat ing the piggy-back approach in the study of NMT as a target for malaria and leishmaniasis.
Synthetic studies and applications of helicenes
Creators: name: Judge, Dilraj
Publisher: name: Imperial College London
Year: 2013

description: Helicenes are ortho-fused aromatic molecules rendered chiral due their unique helical topology. These fascinating molecules with their extended electronic conjugation have vast potential in a variety of applications. Indeed, their applicability has been highlighted in the fields of catalysis1 and molecular recognition2 amongst others. Current methods employed to synthesise helicenes offer little means of stereocontrol. Our group aims to develop a unified, general strategy to enable the asymmetric synthesis of unfunctionalised carbo- and hetero- helicenes. Two chiral relay protocols to control the sense of helical chirality have been investigated: (i) axial chirality to helical chirality and (ii) planar chirality to helical chirality (Figure A1). The use of tricarbonyl chromium moieties as the planar chiral source and probing the conformation of hindered axially chiral compounds is described. In the synthetic route towards [6]helicene, the 1,8-diarylnaphthalene motif represents a key intermediate. Such motifs were prepared by a double Suzuki-Miyaura cross coupling reactions using two different substrates: employing diboronic acid i and bis-iodide iii. The latter substrate afforded dimethoxy v in excellent yield. Subsequent treatment with Cr(CO)6 provided an efficient route to access compound vi which exhibits both axial and planar chirality. These 1,8-diarylnaphthalene motifs exist as atropisomers: syn (meso)- and anti (chiral)- isomers (FigureA2). Further dynamic onformational studies, employing NMR techniques, on these compounds successfully determined the barriers to isomerisation (Table A1), in addition to investigating the solvent dependency on the anti:syn ratio. In the synthetic route towards aza[6]helicene, the development of a C-H activation/arylation reaction of tricarbonyl chromium complexed 2-phenylpyridines has been accomplished. Optimisation of the conditions for the two-step process involving C-H activation by the formation of a isolable palladacycle ix followed by an arylation using various aryl boronic acids furnished triaryl products xii and xiii in moderate to excellent yields (Scheme A3). This methodology was developed into a one-pot activation/arylation process resulting in key intermediate arylated products for the synthesis of aza[6]helicene. The ability of [7]helicene to function as a chiral molecular tweezer of certain metallic cations is described. Formation of a 1:1 Ag:[7]helicene complex was monitored by NMR spectroscopy and its structure was determined by X-ray crystallography (Figure A3).
Branched Organometallic Complexes for Molecular Electronics
Creators: name: Inkpen, Michael Stephen
Publisher: name: Imperial College London
Year: 2013

description: To date, investigations concerning single or small groups of molecules for molecular electronics have largely focussed upon the transfer of electrons from donor to acceptor (electrodes or redox centres), through a single molecular pathway (bridging ligand or linear structure). Herein is described the synthesis and electrochemical properties of some branched and macrocyclic compounds containing {FeCp 2 } and {Ru(dppe) 2 } centres, with phenylene ethynylene backbones and pyridyl-termini for surface binding (Chapters 2 and 5 , respectively). Such systems provide two well-defined molecular pathways for electron transfer, facilitating the study of quantum interference effects and other phenomena resulting from concurrent, and ultimately convergent, electron transport. In addition, the large-scale ‘oxidative purification’ of 1,1’-diiodoferrocene ( 1 ) is presented (Chapter 2) , its usefulness as a starting material being further enhanced by an investigation into the optimisation of its (typically low-moderate yielding) reactions with terminal alkynes under Sonogashira cross-coupling conditions (Chapter 3) . As part of this study, attempts to synthesise 1,1’-bis[(4-thioacetylphenyl)ethynyl]ferrocene from 1 and 4-ethynylphenylthioacetate unexpectedly produced a cyclic trimer (15) of the latter. This observation afforded an explanation as to why the Fc–C≡C–C6H4–SAc motif may not be formed using this approach, and resulted in the realisation of a new route to β-phenylthioketones in general. The linear complex Ru(dppe)2(C≡C–C5H4N)2 (17) has also been prepared – a synthesis complicated by the bifunctional nature of the 4-ethynylpyridine ligand (Chapter 4). It is hoped that future conductance studies of this and extended structures will complement recent work by others on analogous complexes with isonitrile and thiolate-termini. Experiences with protecting the pyridyl nitrogen of 4-ethynylpyridine, and the moderate success of employing N-methyl-4- ethynylpyridinium triflate (19) as a ligand, are detailed. Finally, ‘mixed-valence’ complexes of the type [{M(L) n}2(μ-BL)] (μ-BL = bridging ligand) are discussed and evaluated in light of recently observed correlations between their measured ΔE1/20 values (the difference between sequential redox events, ΔE1/20 = E20 – E10) and IR triple bond frequencies of analogous {M(L) n}–R (R = C≡O, –C≡N–C≡C–Ph) complexes (a indicator of electron density at {M(L) n}) (Chapter 6). Trends in individual contributions to the free energy of comproportionation are explored for complexes of the type [{M(L) n}2(μ-C≡C–C≡C)].
Additional file 2 of Effectiveness of the mHealth intervention ‘MyDayPlan’ to increase physical activity: an aggregated single case approach
Creators: name: Degroote, L.
name: De Paepe, A.
name: De Bourdeaudhuij, I.
name: Van Dyck, D.
name: Crombez, G.
Publisher: name: figshare
Year: 2021
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Additional file 2.
The Cauchy problem for the logarithmic Schrödinger equation revisited
Creators: name: Hayashi, Masayuki
name: Ozawa, Tohru
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We revisit the Cauchy problem for the logarithmic Schrödinger equation and construct strong solutions in $H^1$, the energy space, and the $H^2$-energy space. The solutions are provided in a constructive way, which does not rely on compactness arguments, that a sequence of approximate solutions forms a Cauchy sequence in a complete function space and then actual convergence is shown to be in a strong sense.
description: 30 pages
title:  Population Mobility High-Risk Environments and the Diffusion of HIV/STDS: A Community Based Study in Southwest China
Creators: name: Fu, Hongyun
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2003

description: Globally, population migration has been associated with the spread ofHIV/STDs in many countries. A similar trend has been observed in China from the very beginning of the HIV epidemic, but empirical research is very limited. Furthermore, the previous studies mainly focused on the micro impact of migration on individual migrant's risky behaviors. The impact of population mobility on the general population, especially on non-migrant residents, has been ignored. Using data collected from a specially designed community level survey, which was conducted in a province in the Southwest of China, this study examines the macro-level association between temporary migration and the diffusion of HIV/STDs. It focuses on the contextual environments, which are associated with the spread of HIV/STDs among the general population including non-migrant residents. This study was designed to address the following research questions: Is temporary migration associated with the levels of drug abuse and commercial sex in a community? Are the levels of drug abuse and commercial sex associated with the prevalence of HIV/STDs in a community? Is temporary migration associated with the prevalence of HIV/STDs in a community? Is temporary migration associated with the prevalence of HIV among non-migrant residents in a community?

Analyses reveal some important findings: First, the proportion of temporary migrants in China is positively correlated with the prevalence of drug abuse and the prevalence of commercial sex. Second, the prevalence of drug abuse and the prevalence of commercial sex are positively associated with the prevalence of HIV/STDs. Third, there is a significant and positive relationship between the level of temporary migration and the prevalence of HIV/STDs in a community, and the prevalence of HIV among non-migrant residents. Implications and directions for future research are discussed.
Additional file 3 of Effectiveness of the mHealth intervention ‘MyDayPlan’ to increase physical activity: an aggregated single case approach
Creators: name: Degroote, L.
name: De Paepe, A.
name: De Bourdeaudhuij, I.
name: Van Dyck, D.
name: Crombez, G.
Publisher: name: figshare
Year: 2021
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Additional file 3.
Trochilus forficatus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Apodiformes
Trochilidae
Trochilus
Trochilus forficatus

description: Trochilus forficatus [spec. nov.]
T. curvirostris, rectricibus lateralibus longissimis, corpore viridi, pileo rectricibusque caeruleis.
Polytmus major nigricans aureo varie splendens, pennis binis uropygii longissimis. Brown. jam. p. 475.
Mellivora viridis, cauda longa. Edw. av. 33. t. 33.
Mellivora avis minima. Sloan. jam. 2. p. 307. t. 264. f. 1. Raj, av. 187.
Habitat in Jamaica.
Pennae longissimae basi suffultae supra & infra pennula rigida.
* * Brachyuri 6-18.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 120, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Categorical resolutions of filtered schemes
Creators: name: De Deyn, Timothy
Publisher: name: arXiv
Year: 2023
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14A22, 18G80, 14E15

description: We give an alternative proof of the theorem by Kuznetsov and Lunts, stating that any separated scheme of finite type over a field of characteristic zero admits a categorical resolution of singularities. Their construction makes use of the fact that every variety (over a field of characteristic zero) can be resolved by a finite sequence of blow-ups along smooth centres. We merely require the existence of (projective) resolutions. To accomplish this we put the $\mathcal{A}$-spaces of Kuznetsov and Lunts in a different light, viewing them instead as schemes endowed with finite filtrations. The categorical resolution is then constructed by gluing together differential graded categories obtained from a hypercube of finite length filtered schemes.
description: Final published version
The proximity effect on the Lyman alpha forest due to a a foreground QSO
Creators: name: Fernandez-Soto, A.
name: Barcons, X.
name: Carballo, R.
name: Webb, J. K.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The influence of a foreground QSO on the lyman a forest of another QSO with higher redshift has been investigated by analyzing the spectra of three such objects at redshifts $z=2 - 2.7$. This influence is not contaminated by any projection effects, as opposed to the inverse effect along the line of sight, where incomplete coverage of the QSO continuum emitting region by the lyman a clouds could contribute to the relative lack of lines. Our results are consistent with the existence of a proximity effect due to the foreground QSO, but due to its weakness we can only reject the absence of such effect at 1 sigma level. By modelling this proximity effect assuming that lyman a clouds are low-density highly ionized objects we find that the best value for the UV photoinizing intensity at those redshifts is 10^{-20.5}(...) at the Lyman limit which is consistent with previous estimates of the background based on the inverse effect. We also find an absolute lower limit (at 95% confidence) to the UV intensity at the level of 10^{-21.8}(...) which means the rejection of a number of models for the UV background.
description: 10 pages + tar file with 6 figures and 4 pages of tables, uses MNRAS style files
The morphological mix of field galaxies to I=24.25 magnitudes (b=26 magnitudes) from a deep Hubble Space Telescope WFPC2 image
Creators: name: Driver, Simon P.
name: Windhorst, Rogier A.
name: Ostrander, Eric J.
name: Keel, William C.
name: Griffiths, Richard E.
name: Ratnatunga, Kavan U.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We determine the morphological mix of field galaxies down to $m_{I}\simeq 24.25$ mag ($m_{B}\sim 26.0$ mag) from a single ultradeep HST WFPC2 image in both the $V_{606}$ and $I_{814}$ filters. In total, we find 227 objects with $m_{I}\le 24.5$ mag and classify these into three types: ellipticals (16%), early-type spirals (37%) and late-type spirals/Irregulars (47%). The differential number counts for each type are compared to simple models in a standard flat cosmology. We find that both the elliptical and early-type spiral number counts are well described by {\it little or no}-evolution models, but only when normalized at $b_{J} = 18.0$ mag. Given the uncertainties in the luminosity function (LF) normalization, both populations are consistent with a mild evolutionary scenario based on a normal/low rate of star-formation. This constrains the end of the last {\it major} star-formation epoch in the giant galaxy populations to $z\geq 0.8$. Conversely, the density of the observed late-type/Irregular population is found to be a factor of 10 in excess of the conventional no-evolution model. This large population might be explained by either a modified {\it local} dwarf-rich LF, and/or strong evolution acting on the {\it local} LF. For the dwarf-rich case, a {\it steep} faint-end Schechter-slope ($α\simeq -1.8$) is required plus a five-fold increase in the dwarf normalization. For a purely evolving model based on a {\it flat} Loveday {\it et al.} (1992) LF ($α\simeq -1.0$), a ubiquitous starburst of $ΔI\sim$2.0 mag is needed at z$\simeq 0.5$ for the {\it entire} late-type population. We argue for a combination of these possibilities, and show that for a steep Marzke {\it et al.} (1994) LF ($α\simeq -1.5$), a starburst of $\sim$ 1.3 mag is required
description: 9 pages, 3 figures (2 colour). The figures are available at http://www.phys.unsw.edu.au/~spd/bib.html
N-body simulations of galaxies and groups of galaxies with the Marseille GRAPE systems
Creators: name: Athanassoula, E.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: I review the Marseille GRAPE systems and the N-body simulations done with them. I first describe briefly the available hardware and software, their possibilities and their limitations. I then describe work done on interacting galaxies and groups of galaxies. This includes simulations of the formation of ring galaxies, simulations of bar destruction by massive compact satellites, of merging in compact groups and of the formation of brightest members in clusters of galaxies.
description: 13 pages, 5 figures, to be published in "Non-linear Dynamics and Chaos in Astrophysics", eds. J.R. Buchler, S. Gottesman, J. Hunter and H. Kandrup, Annals of the New York Academy of Sciences
Are disappearing dwarfs just lying low ?
Creators: name: Phillipps, Steven
name: Driver, Simon P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent redshift surveys have shown that the excess galaxies seen in faint galaxy number counts (above those expected given the local galaxy luminosity function) are not evolved giants at high redshifts, but low to moderate luminosity objects at more modest redshifts. This has led to the suggestion that there was once an additional population of dwarf galaxies which has since disappeared, ie. there is non-conservation of galaxy number. Here we investigate the possibility that these disappearing dwarfs have actually evolved to become the population of very low surface brightness galaxies which is now being detected in nearby clusters.
description: 12 pages, 7 figures. Figures available from http://www.phys.unsw.edu.au/~spd/bib.html