cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation
Creators: name: Bol, Vanesa
name: Bouzin, Caroline
name: Lee, John A.
name: Janssens, Guillaume
name: Porporato, Paolo E.
name: Sonveaux, Pierre
name: Feron, Olivier
name: Grégoire, Vincent
name: Bol, Anne
name: Labar, Daniel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Background. The Warburg phenotype identified decades ago describes tumor cells with increased glycolysis and decreased mitochondrial respiration even in the presence of oxygen. This particular metabolism also termed ‘aerobic glycolysis’ reflects an adaptation of tumor cells to proliferation in a heterogeneous tumor microenvironment. Although metabolic alterations in cancer cells are common features, their impact on the response to radiotherapy is not yet fully elucidated. This study investigated the impact of cellular oxygen consumption inhibition on the tumor response to radiotherapy.Material and methods. Warburg-phenotype tumor cells with impaired mitochondrial respiration (MD) were produced and compared in respect to their metabolism to the genetically matched parental cells (WT). After characterization of their metabolism we compared the response of MD cells to irradiation in vivo and in vitro to the genetically matched parental cells (WT).Results. We first confirmed that MD cells were exclusively glycolytic while WT cells exhibited mitochondrial respiration. We then used these cells for assessing the response of WT and MD tumors to a single dose of radiation and showed that the in vivo tumor growth delay of the MD group was increased, indicating an increased radiosensitivity compared to WT while the in vitro ability of both cell lines to repair radiation-induced DNA damage was similar.Conclusion. Taken together, these results indicate that in addition to intrinsic radiosensitivity parameters the tumor response to radiation will also depend on their metabolic rate of oxygen consumption.
Nontargeted Urine Metabolomics with Electrospray Ionization-Mass Spectrometry Reveals the Major Metabolic Characterization between Adult Males and Females Involved in Calcium Oxalate Urolithiasis
Creators: name: Wang, Rui
name: Qi, Shiyong
name: Zhang, Jingdong
name: Ren, Haotian
name: Xie, Linguo
name: Liu, Chunyu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: The incidence of calcium oxalate (CaOx) urolithiasis between men and women is considerably different. However, the full-scale metabolic changes between genders with CaOx urolithiasis have not been reported. The metabolic profiles in 112 urine samples obtained from 61 males and 51 females diagnosed with CaOx stones were characterized using electrospray ionization-mass spectrometry (ESI-MS). Univariate, multivariate, and bioinformatic analyses were employed to reveal the differential metabolites and perturbed metabolic pathways between genders. In total, 30 dysregulated metabolites were identified as differential metabolites between males and females with CaOx urolithiasis. The primary metabolic pathways were caffeine metabolism, metabolic pathways, and biosynthesis of amino acids. Furthermore, 10 potential metabolites which were mostly contributed to separating the males and female were selected using feature weight calculation. These compounds included creatinine, 3-methylhistidine, n-acetylneuraminic acid, decanoyl-l-carnitine, cortisone, nicotine, 1-methyluric acid, androsterone sulfate, citramalic acid, and 1,7-dimethylxanthine. Finally, a subset of the differential metabolites was identified by receiver operating characteristic (ROC) curve analysis, including creatinine, 3-methylhistidine, n-acetylneuraminic acid, decanoyl-l-carnitine, and 1-methyluric acid (area under the curve = 0.924, 0.844, 0.846, 0.814, 0.814). These metabolites had higher risks in the CaOx stone formation of males than females. The study showed that there were a group of differential metabolites between the males and females with CaOx stones. A subset of these compounds was more closely and positively related to renal stone formation in males than females. Moreover, these metabolites may be the cause of the differences in the incidence of CaOx urolithiasis between genders.
Additional file 1 of Chronic headache patients’ health behavior and health service use 12 months after interdisciplinary treatment – what do they keep in their daily routines?
Creators: name: Donath, Carolin
name: Luttenberger, Katharina
name: Geiß, Christa
name: Albert, Patricia
name: Fraunberger, Britta
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Outcomes of stereotactic radiotherapy for cranial and extracranial metastatic renal cell carcinoma: A systematic review
Creators: name: Foroudi, Farshad
name: Corcoran, Niall M.
name: Siva, Shankar
name: Gargi Kothari
name: Suki Gill
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology

description: Background. Stereotactic radiotherapy is a non-invasive, ablative technique which may be particularly effective in treating metastatic renal cell carcinoma (RCC). The study objective was to analyse outcomes and toxicity of stereotactic radiotherapy in metastatic RCC.Material and methods. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of Medline was performed in March 2013. Exclusion criteria included mixed histology studies and case series. Local control, overall survival and toxicities were analysed.Results. From 148 publications identified, 16 and 10 publications for cranial and extracranial metastatic RCC met inclusion criteria, respectively. There were 810 intracranial patients and 2433 targets. The weighted local control was 92%. Overall survival ranged from 6.7 to 25.6 months. Significant Grade 3–4 toxicity ranged from 0% to 6%. The weighted rate of treatment-related mortality was 0.6%, all secondary to intratumoral haemorrhage. There were 389 extracranial patients and 730 targets. The weighted local control was 89%. Median overall survival ranged from 11.7 to 22 months. Grade 3–4 toxicity ranged from 0% to 4%. Treatment-related mortality was 0.5%.Conclusion. Stereotactic radiotherapy is associated with excellent local control and low rates of toxicity for intracranial and extracranial metastatic RCC. Future randomised studies are required to confirm the additional benefit of Stereotactic Ablative Body Radiotherapy (SABR) above standard conservative or palliative approaches.
Building energy index (BEI) of hospital buildings in Iraq: A case study
Creators: name: Anwer Abdulhussein Gatea
name: Mohd Faizal Mohideen Batcha
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: building energy index
hospital
energy efficiency

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1779-1785
Fluorescent Determination of Ferric Ion in vitro with Carbon Quantum Dots Prepared by L-Arginine and Citric Acid
Creators: name: Zhang, Yuding
name: Xie, Mengyao
name: Ma, Gongcheng
name: Chen, Huajie
name: Li, Dai
name: Guan, Lijiao
name: Zhang, Xianfen
name: Wu, Jiyong
name: Huang, Saipeng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Virology

description: Ferric ion (Fe3+) serves as an essential and indispensable inorganic element in various biological process. Excess Fe3+ is harmful for biological systems and human health. Herein, highly sensitive carbon quantum dots (Fe-CQDs) for ferric ions were synthesized by a high-efficiency, one-step hydrothermal route utilizing L-arginine and citric acid. The prepared Fe-CQDs exhibited good water solubility, high photostability, and bright blue florescence with relatively high quantum yields (QYs) over 21.33% and a Stokes shift exceeding 100 nm. The functionalized Fe-CQDs offer rapid, sensitive, and selective recognition of Fe3+ with a linear relationship from 0.6 to 80 μM and a low detection limit of 0.2 μM. Moreover, the synthesized Fe-CQDs illustrated strong anti-interference properties in samples and buffer solutions. The developed sensor demonstrated high biocompatibility and was successfully applied for intracellular Fe3+ determination in SHSY5Y and HT22 cells, illustrating excellent imaging application. The present work provides a promising platform for the early clinical diagnosis of Fe3+-associated diseases.
Additional file 1 of Domestic violence in Indian women: lessons from nearly 20 years of surveillance
Creators: name: Dandona, Rakhi
name: Gupta, Aradhita
name: George, Sibin
name: Kishan, Somy
name: Kumar, G. Anil
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Definitions of crime headings considered under domestic violence. IPC denotes Indian Penal Code.
Determination of the Degradation Products of Pheomelanin as Potential Biomarker for Early-Stage Melanoma by Gas Chromatography-Mass Spectrometry (GC-MS)
Creators: name: Cheng, Wenhan
name: Lee, JianHong
name: Miller, Emily
name: Jackson, Bryan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The pheomelanin precursor 5-S-cysteinyldopa (5SCD) exhibits promising potential as a urinary and serum biomarker for melanoma. Nonetheless, it is important to note that 68.8% of early-stage melanoma cases remained undetected when employing 5SCD as a biomarker, underscoring the inadequacy of its efficacy, especially in identifying stage I/II melanoma. In lieu of detecting free 5SCD, the hydrolysis products of pheomelanin, namely, 4-amino-3-hydroxyphenylalanine (4-AHP) and 3-amino-4-hydroxyphenylalanine (3-AHP) offer the prospect of achieving heightened sensitivity and broader scope in early-stage melanoma diagnosis through direct chemical processes. This study introduces an innovative gas chromatography-mass spectrometry (GC-MS) methodology to identify early-stage melanoma by comparing the concentrations of AHPs across 80 stage I/II melanoma patients against 32 healthy controls. The approach demonstrated linear response within the 0.5–20 μg/mL range for reference AHPs detection. The urine levels of AHPs were 1.3 ± 0.5 μg/mL in the control/volunteer group (n = 32), 8.1 ± 1.6 μg/mL in stage I and II melanoma patients (n = 28), and 6.3 ± 1.9 μg/mL in stage II melanoma patients (n = 52). The findings unequivocally underscore the diagnostic promise of AHPs as a robust tool for early-stage melanoma assessment in laboratory medicine.
Capture rate and representativity of The National Prostate Cancer Register of Sweden
Creators: name: Berglund, Anders
name: Robinson, David
name: Lambe, Mats
name: Stattin, Pär
name: Tomic, Katarina
name: Hjälm-Eriksson, Marie
name: Carlsson, Stefan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Science Policy
subject: Cancer
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology
subject: Medicine

description: Background. Capture rate and representativity of quality registers need to be assessed in order to ensure that register data are generalizable.Material and methods. In 1998–2009, 103 047 men had been diagnosed with prostate cancer and registered in the Swedish Cancer Register to which registration is mandated by law and of these men, 100 849 men (98%) had also been registered in The National Prostate Cancer Register (NPCR) of Sweden. We compared demographics, cancer treatment, comorbidity, and mortality in men in NPCR, with those who had only been registered in the Cancer Register, by use of data from the Cause of Death Register, the In-Patient Register and the Prescribed Drug Register. In addition, we identified 1929 men who had prostate cancer as underlying cause of death in the Cause of Death Register who had neither been registered in the Cancer Register nor in NPCR.Results. Compared to men in NPCR, men only registered in the Cancer Register were slightly older, median age 72 versus 71 years, and a lower proportion underwent radical prostatectomy, 15% versus 27%. Ten year prostate cancer mortality was 23% (95% CI 20–25) for men in the Cancer Register only and 24% (95% CI 24–25) in NPCR, while mortality from competing causes was 28% (95% CI 26–31) and 30% (95% CI 30–30), respectively. Men identified with prostate cancer by a death certificate were old and had high comorbidity.Conclusion. The capture rate of NPCR is very high and there are only modest differences in demographics, cancer treatment, comorbidity, and mortality between the small proportion of men only registered in the Cancer Register and men registered in NPCR, indicating that information in NPCR can be generalized to all men with prostate cancer in Sweden.
Dose-response of acute urinary toxicity of long-course preoperative chemoradiotherapy for rectal cancer
Creators: name: Appelt, Ane L.
name: Bentzen, Søren M.
name: Jakobsen, Anders
name: Vogelius, Ivan R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Pharmacology
subject: Cell Biology
subject: Medicine

description: Background. Long-course preoperative chemoradiotherapy (chemo-RT) improves outcomes for rectal cancer patients, but acute side effects during treatment may cause considerable patient discomfort and may compromise treatment compliance. We developed a dose-response model for acute urinary toxicity based on a large, single-institution series.Material and methods. In total 345 patients were treated with (chemo-)RT for primary rectal cancer from January 2007 to May 2012. Urinary toxicity during RT was scored prospectively using the CTCAE v 3.0 cystitis score (grade 0–5). Clinical variables and radiation dose to the bladder were related to graded toxicity using multivariate ordinal logistic regression. Three models were optimized, each containing all available clinical variables and one of three dose metrics: Mean dose (Dmean), equivalent uniform dose (EUD), or relative volume given x Gy or above (dose cut-off model, Vx). The optimal dose metric was chosen using the Akaike Information Criterion (AIC).Results. Grade 1 cystitis was experienced by 138 (40%), grade 2 by 39 (11%) and grade 3 by two (1%) patients, respectively. Dose metrics were significantly correlated with toxicity in all models, but the dose cut-off model provided the best AIC value. The only significant clinical risk factors in the Vx model were male gender (p = 0.006) and brachytherapy boost (p = 0.02). Reducing the model to include gender, brachytherapy boost and Vx yielded odds ratios ORmale = 1.82 (1.17–2.80), ORbrachy = 1.36 (1.02–1.80 for each 5 Gy), x = 35.1 Gy (28.6–41.5 Gy). The predicted risk of grade 2 and above cystitis ranged from 2% to 26%.Conclusion. Acute cystitis correlated significantly with radiation dose to the bladder; the dose-cut-off model (V35Gy) was superior to Dmean and EUD models. Male gender and brachytherapy boost increased the risk of toxicity. Wide variation in predicted risks suggests room for treatment optimization using individual dose constraints.
MPEC 2024-E66 : 2024 EO1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 EO1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Post-treatment for high content of ethyl esterfrom esterification of palm fatty acid distillate
Creators: name: Waritorn Kanjaikaew
name: Chakrit Tongurai
name: Sininart Chongkhong
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: post-treatment
palm fatty acid distillate
esterification
ethyl ester
kinetics

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1786-1792
Prospective phase II trial of image-guided radiotherapy in Hodgkin lymphoma: Benefit of deep inspiration breath-hold
Creators: name: Aznar, Marianne C.
name: Specht, Lena
name: Petersen, Peter M.
name: Berthelsen, Anne K.
name: Loft, Annika
name: Schut, Deborah A.
name: Maraldo, Maja
name: Josipovic, Mirjana
name: Klausen, Thomas L.
name: Andersen, Flemming L.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Physics

description: Background. Long-term Hodgkin lymphoma (HL) survivors have an increased risk of late cardiac morbidity and secondary lung cancer after chemotherapy and mediastinal radiotherapy. In this prospective study we investigate whether radiotherapy with deep inspiration breath-hold (DIBH) can reduce radiation doses to the lungs, heart, and cardiac structures without compromising the target dose.Patients and methods. Twenty-two patients (14 female, 8 male), median age 30 years (18–65 years), with supra-diaphragmatic HL were enrolled and had a thoracic PET/CT with DIBH in addition to staging FDG-PET/CT in free breathing (FB) and a planning CT in both FB and DIBH. For each patient an involved-node radiotherapy plan was done for both DIBH and FB, and the doses to the lungs, heart, and female breasts were recorded prospectively. Mean doses to the heart valves and coronary arteries were recorded retrospectively. Patients were treated with the technique yielding the lowest doses to normal structures.Results. Nineteen patients were treated with DIBH and three with FB. DIBH reduced the mean estimated lung dose by 2.0 Gy (median: 8.5 Gy vs. 7.2 Gy) (p < 0.01) and the mean heart dose by 1.4 Gy (6.0 Gy vs. 3.9 Gy) (p < 0.01) compared to FB. The lung and heart V20Gy were reduced with a median of 5.3% and 6.3%. Mean doses to the female breasts were equal with FB and DIBH.Conclusion. DIBH can significantly decrease the estimated mean doses to the heart and lungs without lowering the dose to the target in radiotherapy for patients with mediastinal HL.
title: Optische Untersuchungen zur Gemischbildung, Selbstzündung und Rußbildung von Polyoxymethylendimethylether (OME)
Creators: name: Weiss, Lukas
Publisher: name: Shaker
Year: 2022
Subjects: subject: Diesel, Ruß, OME, Spray, Verbrennung, Motor, Thermodynamik, Optische Messtechnik, e-Fuel

description: Diese Arbeit steht im Kontext einer Entwicklung von Technologiekonzepten zur Darstellung einer nachhaltigen und klimaneutralen Mobilität. Um diese EU weit bis 2050 umzusetzen, muss ein signifikanter Beitrag auch durch e-Fuels, aus erneuerbaren Energien synthetisch hergestellter Kraftstoff, erfolgen. Einer der interessanten Vertreter von e-Fuels ist OME, einem organischen Kettenmolekül, dessen Kettenstruktur alternierend aus Kohlenstoff und Sauerstoff aufgebaut ist und keine Nebenketten hat. In ersten Kraftstoff-Studien ist OME durch seine besonders rußarme Verbrennung im Ver-gleich zu anderen sauerstoffreichen Kraftstoffen aufgefallen. Daher wird in dieser Arbeit die Prozesskette der OME Verbrennung unter motorischen Randbedingungen am Beispiel von OME3-6 untersucht (Der Index gibt die Kettenlänge des Moleküls an). Im Detail wird auf die Einspritzung und Gemischbildung, die Zündung sowie die Rußbildung im Vergleich zu Dodekan und GtL-Diesel eingegangen. Die Fragestellungen der Untersuchung sind, in wie-weit die Prozesse von OME vergleichbar zu konventionellen Kraftstoffen sind und wodurch die geringe Rußbildung erklärt werden kann. Während andere Kraftstoffe mit ähnlichem Sauerstoffanteil wie OME in der Literatur sehr geringe, aber dennoch vorhandene Rußbildung zeigen sind im Fall von OME keine Anzeichen von Ruß in der primären Verbrennung erkennbar. Diese Aussage basiert nicht nur darauf, dass keine thermische Rußstrahlung detektiert werden kann, sondern auch darauf, dass weder PAH als Rußvorläufer noch der elementare Grundbaustein CH* nachweisbar ist. Diese Erkenntnis sagt, dass generell bei sauerstoffhaltigen Kraftstoffen vielmehr die vorhandene C-O Bin-dung als der lokal niedrige Sauerstoffbedarf zur geringen Rußbildung beiträgt.
Enhanced volatile fatty acids production from Napier grass(Pennisetum purpureum) using micro-aerated anaerobic culture
Creators: name: Chayanon Sawatdeenarunat
name: Rotjapun Nirunsin
name: Sumate Chaiprapat
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: micro-aeration
lignocellulosic biomass
volatile fatty acids
digestate
anaerobic digestion

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1793-1799
A systematic decision-making approach for the assessment of hybridrenewable energy applications with techno-economic optimization:Application to the Rajamangala University of Technology Srivijaya(Trang Campus), Southern Thailand
Creators: name: Weerasak Chaichan
name: Jompob Waewsak
name: Gagnon, Yves
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: hybrid renewable energy
optimization
net present cost
levelized cost of energy
energy storage

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1800-1806
Application of Hjorth parameters in the classificationof healthy aging EEG signals
Creators: name: Javaid, Hamad
name: Krit Charupanit
name: Ekkasit Kumarnsit
name: Surapong Chatpun
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: electroencephalography
aging
Hjorth parameters
k-nearest neighbor
classification

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1807-1814
Steady-state analysis of suitable interconnection pointsfor integration of offshore wind farms in the Gulf of Thailand
Creators: name: Kusumal Chalermyanont
name: Phichet Ketsamee
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: large-scale wind farm
interconnection point
fault currents
power flows
voltage stability
voltage variations
Gulf of Thailand

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1815-1822
Floating search and conditional independence testingfor causal feature selection
Creators: name: Rakkrit Duangsoithong
name: Yuying Zhao
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: causal feature selection
floating search
redundant features
conditional independence testing
classification accuracy

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1823-1830
Motorcycle detection based on deep learning implemented on FPGA
Creators: name: Peng, Feng
name: Kittikhun Thongpull
name: Ikura, Masami
name: Nattha Jindapetch
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: motorcycle detection
deep learning
YOLOv2
FPGA
high-level synthesis

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1831-1839
Relación andaluza de las hazañas hechos y valentías de Pepillo el Jerezano: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Relación andaluza de las hazañas hechos y valentías de Pepillo el Jerezano: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Supplementary Material from Diverse parentage relationships in paternal mouthbrooding fishes
Creators: name: Abecia, Janine E.
name: King, Alison J.
name: Luiz, Osmar J.
name: Crook, David A.
name: Wedd, Dion
name: Banks, Sam C.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: While mouthbrooding is not an uncommon parental care strategy in fishes, paternal mouthbrooding only occurs in eight fish families and is little studied. The high cost of paternal mouthbrooding to the male implies a low risk of investment in another male's offspring but genetic parentage patterns are poorly known for paternal mouthbrooders. Here, we used single-nucleotide polymorphism genetic data to investigate parentage relationships of broods of two mouthbrooders of northern Australian rivers, mouth almighty Glossamia aprion and blue catfish Neoarius graeffei. For N. graeffei, we found that the parentage pattern was largely monogamous with the brooder male as the sire. For G. aprion, the parentage pattern was more heterogeneous including observations of monogamous broods with the brooder male as the sire (73%), polygyny (13%), cuckoldry (6%) and a brood genetically unrelated to the brooder male (6%). Findings demonstrate the potential for complex interrelationships of male care, paternity confidence and mating behaviour in mouthbrooding fishes.
Cancer mortality and other causes of death in users of geothermal hot water
Creators: name: Adalbjorg Kristbjornsdottir
name: Vilhjalmur Rafnsson
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine

description: Background. Residents of geothermal areas have increased incidence of non-Hodgkin's lymphoma, breast, prostate, and kidney cancers. The aim was to study whether this is also reflected in cancer mortality among the population using geothermal hot water for space heating, washing, and showering.Methods. The follow-up was from 1981 to 2009. Personal identifier of those 5–64 years of age was used in record linkage with nationwide death registry. Thus, vital and emigration status was ascertained. The exposed population was defined as inhabitants of communities with district heating generated from geothermal wells since 1972. Reference populations were inhabitants of other areas with different degrees of volcanic/geothermal activity. Hazard ratio (HR) and 95% confidence intervals (CI) were adjusted for age, gender, education, housing, reproductive factors and smoking habits.Results. Among those using geothermal water, the HR for all causes of death was 0.98 (95% CI 0.91–1.05) as compared with cold reference area. The HR for breast cancer was 1.53 (1.04–2.24), prostate cancer 1.74 (1.21–2.52), kidney cancer 1.78 (1.03–3.07), and for non-Hodgkin's lymphoma 2.01 (1.05–3.38). HR for influenza was 3.36 (1.32–8.58) and for suicide 1.49 (1.03–2.17).Conclusion. The significant excess mortality risk of breast and prostate cancers, and non-Hodgkin's lymphoma confirmed the results of similarly designed studies in Iceland on cancer incidence among populations from high-temperature geothermal areas and users of geothermal hot water. The risk is not confined to cancers with good prognosis, but also concerns fatal cancers. Further studies are needed on the chemical and physical content of the water and the environment emissions in geothermal areas.
Relación andaluza de las hazañas hechos y valentías de Pepillo el Jerezano: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Risk of recurrence in patients with colon cancer stage II and III: A systematic review and meta-analysis of recent literature
Creators: name: Kaprio, Tuomas
name: Hansen, Torben F.
name: Glimelius, Bengt
name: Böckelman, Camilla
name: Engelmann, Bodil E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Chemistry
subject: Biotechnology

description: Background. Adjuvant chemotherapy is established routine therapy for colon cancer (CC) patients with radically resected stage III and ‘high-risk’ stage II disease. The decision on recommending adjuvant chemotherapy, however, is based on data from older patient cohorts not reflecting improvements in pre-operative staging, surgery, and pathological examination. The aim is to review the current risk of recurrence in stage II and III patients and second, to estimate the relative importance of routinely assessed clinico-pathological variables.Methods. The PubMed/MEDLINE and the Cochrane databases were systematically searched for randomized controlled studies and observational studies published after 1 January 2005 with patients included after January 1995 on prognosis in surgically treated stage II and III CC patients.Results. Of 2596 studies identified, 37 met the inclusion criteria and 25 provided data for meta-analysis. The total patient sample size in the 25 studies reporting either disease-free (DFS) or recurrence-free survival was 15 559 in stage II and 18 425 in stage III. Five-year DFS for stage II patients operated without subsequent adjuvant chemotherapy was 81.4% [95% confidence interval (CI) 75.4–87.4; in studies with good/very good quality of reporting 82.7%, (95% CI 80.8–84.6)]. For stage II patients treated with adjuvant chemotherapy, the five-year DFS was 79.3% (95% CI 75.6–83.1). For stage III patients without chemotherapy, five-year DFS was 49.0% (95% CI 23.2–74.8) and for those treated with adjuvant chemotherapy, 63.6% (95% CI 59.3–67.9). The prognostic impact of commonly investigated clinico-pathological parameters, (pT-stage, pN-stage, differentiation, number of lymph nodes studied, MMR-status, and emergency surgery) were confirmed.Conclusions. In this meta-analysis, studies with good quality of reporting show a five-year DFS of 82.7% for stage II CC without adjuvant chemotherapy, whereas the five-year DFS is 63.8% for stage III CC with adjuvant chemotherapy. Due to insufficient reporting on treatment quality the presented DFS is likely an under-estimation of what is achieved at high-quality centers today.
Dose intensified hypofractionated intensity-modulated radiotherapy with synchronous cetuximab for intermediate stage head and neck squamous cell carcinoma
Creators: name: Thomson, David J.
name: Ho, Kean F.
name: Ashcroft, Linda
name: Denton, Kim
name: Betts, Guy
name: Mais, Kathleen L.
name: Garcez, Kate
name: Beng K. Yap
name: Lip W. Lee
name: Sykes, Andrew J.
name: Rowbottom, Carl G.
name: Slevin, Nicholas J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Cancer
Cell Biology

description: Background. For stage II and III head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy alone, loco-regional recurrence is the main cause of treatment failure. Strategies to improve loco-regional control should not be at the expense of increased late normal tissue toxicity. We investigated dose-intensified hypofractionated intensity-modulated radiotherapy (IMRT) with synchronous cetuximab.Material and methods. In a phase I/II trial, 27 patients with stage III or high risk stage II HNSCC were recruited. They received three dose level simultaneous integrated boost IMRT, 62.5 Gy in 25 daily fractions to planning target volume one over five weeks with synchronous cetuximab. The primary endpoint was acute toxicity. Secondary endpoints included: late toxicity and quality of life; loco-regional control, cause-specific and overall survival.Results. Radiotherapy was completed by 26/27 patients; for one (4%) the final fraction was omitted due to skin toxicity. All cycles of cetuximab were received by 23/27 patients. Grade 3 acute toxicities included: pain (81%), oral mucositis (78%) and dysphagia (41%). There were few grade 3 physician-recorded late toxicities, including: pain (11%), problems with teeth (8%) and weight loss (4%). At 12 months, only one (4%) patient required a feeding tube, inserted prior to treatment due to dysphagia. The maximal/peak rates of patient-reported late toxicities included: severe pain (11%), any dry mouth (89%) and swallowing dysfunction that required a soft/liquid diet (23%). At 12 months, all quality of life and most symptoms mean scores had resolved to baseline or were only a little worse; dry mouth, sticky saliva and dentition scores remained very much worse. At a median follow-up of 47 months, there were five (18.5%) loco-regional recurrences and the overall cause-specific survival was 79% (95% CI 53–92).Conclusions. This regimen is safe with acceptable acute toxicity, low rates of late toxicity and impact on quality of life at 12 months following treatment. Further evaluation is recommended.
Supplementary document for Compact freeform-surface-based Offner imaging spectrometer with both long-slit and broadband - 6885189.pdf
Creators: name: Sun, Shu
name: Gao, Yanhong
name: Ji, Yiqun
name: Zhao, ShiJia
name: Han, Jizhou
name: Wang, Chinhua
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: The astigmatism expressions introduced by the other Zernike polynomial terms below the eighth order
Avaliação Formativa e Autorregulação da Aprendizagem nos Anos Finais do Ensino Fundamental:
Creators: name: Santana, Elâine Nunes Batista
name: Tavares, Cristina Zukowsky-
Publisher: name: Internet Latent Corpus Journal
Year: 2024

description: A autorregulação da aprendizagem consiste em um processo amplo e complexo, pois é por meio dele que o estudante é capaz de orientar, monitorar e despertar a própria aprendizagem, tornando-se o protagonista do processo. O objetivo do presente estudo é direcionar uma revisão integrativa da literatura sobre a autorregulação da aprendizagem nos anos finais do Ensino Fundamental. Para alcançar esse objetivo, foram acessadas as seguintes bases de dados: ERIC, Periódicos CAPES e SCIELO, utilizando o descritor: “Autorregulação da aprendizagem”, foram utilizados filtros delimitando o período de 2018 a 2023. A partir da pesquisa nas bases de dados, foram encontrados 123 estudos, que passaram por um processo de triagem, restando 4 que foram incluídos no presente estudo. Este estudo proporcionou uma visão mais aprofundada sobre como uma relação sólida entre família e escola interfere no fortalecimento da autonomia dos estudantes, tornando-os capazes de criar e monitorar suas estratégias de autorregulação da aprendizagem. Ao capacitar os estudantes a se tornarem protagonistas de sua própria aprendizagem, abre-se caminho para um desenvolvimento acadêmico mais significativo. Além disso, evidenciou que os docentes devem estimular a autorreflexão e autoavaliação nos estudantes, para que estes avaliem seus próprios resultados e a partir deles, desenvolvam estratégias autorregulatórias.
description: Internet Latent Corpus Journal, vol. 14 n.º 1 (2024): .
A retrospective safety and efficacy analysis of the first patients treated with eribulin for metastatic breast cancer in Stockholm, Sweden
Creators: name: Margolin, Sara
name: Bergh, Jonas
name: Kessler, Luisa
name: Falato, Claudette
name: Foukakis, Theodoros
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Medicine

description: Backgrounds. Eribulin is a non-taxane, microtubule dynamics inhibitor approved for the treatment of patients with metastatic breast cancer (MBC) in Europe in March 2011.Material and methods. For the purpose of an internal quality control, all patients with MBC treated with eribulin at Karolinska University Hospital were registered in a database. Clinical data were collected retrospectively for patients that were registered by August 2012 and safety and efficacy of eribulin were evaluated. Treatment toxicity including fatigue, neurotoxicity and infection was graded according to CTCAE v4.0. Objective response to treatment was investigated using routinely performed radiological assessments. When only clinical assessments were made, the evaluation of the treating physician was used. Furthermore, the efficacy of eribulin was investigated in different tumor subtypes.Results. Forty-eight patients who received at least one cycle of eribulin were identified. Most patients were heavily pretreated with a median of 3 (range 1–7) previous chemotherapy lines prior to eribulin. Median patient age was 56 years (range 35–74). At the end of the analysis, 23 patients were alive and two were still treated with eribulin. No hypersensitivity reactions and no toxic deaths were seen. Fatigue grade 3–4 was observed in three patients (6.3%). One patient experienced grade 4 neurotoxicity. Grade 3–4 neutropenia was documented in 18.8%, and three patients were treated for a grade 3 infection. Interestingly, three individuals developed Herpes zoster reactivation. One patient responded to treatment with complete remission, while 33.3% had a partial response. 48% of all patients had a clinical benefit (objective response or stable disease for more than six months).Conclusions. Eribulin administered outside of a clinical trial in patients with advanced breast cancer was safe and well tolerated. A clinical benefit was seen in half of the cases. No statistically significant differences in objective response or survival were observed between histopathological subgroups.
Electronic Supplementary material – Methods from No evidence of immediate fitness benefits of within-season divorce in monogamous birds
Creators: name: Culina, Antica
name: Brouwer, Lyanne
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: File contains: 1.Details on literature search and PRISMA diagrams; 2. Details on calculating the effect sizes; 3. Reasons for exclusion or pooling of effect sizes; 4.Additional post-hoc decisions in dataset construction
Electronic Supplementary material –Results from No evidence of immediate fitness benefits of within-season divorce in monogamous birds
Creators: name: Culina, Antica
name: Brouwer, Lyanne
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Contains model selection results tables and supplementary figures
Nuclear maspin expression as a predictive marker for fluorouracil treatment response in colon cancer
Creators: name: Brydøy, Marianne
name: Dahl, Olav
name: Hestetun, Kjersti Elvestad
name: Myklebust, Mette Pernille
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Background. Maspin is a member of the serpin family of protease inhibitors whose function in colorectal cancer is not fully understood. The objective of this study was to determine whether level of maspin expression could have prognostic or predictive value in colorectal cancer.Material and methods. Maspin expression was assessed using immunohistochemistry on tissue microarrays obtained from 380 patients with stage II and III colorectal cancer randomized to adjuvant chemotherapy with fluorouracil and levamisole (5-FU/Lev) or to surgery only (control), with scores (0–300) based on presence (0–100) and intensity (0–3) of maspin expression. Associations with disease-free survival (DFS), cancer-specific survival (CSS) and prognostic factors were determined.Results. Maspin expression was predominantly nuclear and present in tumor tissue in 99% of the cases. No associations with clinicopathological factors were identified. In colon cancer patients receiving adjuvant chemotherapy, maspin expression level was significantly associated with CSS [HR 1.43 per 50 points increase in maspin score (p = 0.021)] in multivariate analyses, and a significant interaction between treatment status and maspin expression (p = 0.045) was found. Kaplan-Meier plots from colon cancer patients showed a significant treatment benefit in patients with low maspin expression, but not for individuals with medium/high expression. Level of maspin expression was not significantly related to clinical outcome in rectal cancer or in any of the control groups.Conclusions. In patients with colon cancer a low nuclear maspin expression was an independent predictor of benefit from adjuvant chemotherapy with 5-FU/Lev. A prognostic value of maspin expression was not found in this material.
SCICOMOVE Data Management Plan
Creators: name: Anne Jaouen, Nathalie Richard
Publisher: name: Zenodo
Year: 2022
Subjects: data, FAIR, publication, open access, open science,

description: The present document is the first version of the SciCoMove’s Data Management Plan (D1.1) to be submitted in the first six months of the project’s implementation. It contains preliminary information about the data that will be generated during the project. It outlines the principles adopted by the consortium to make these data accessible and reusable according to FAIR principles. It also takes into account the ethical aspects linked to the use of certain specific data which, without being sensitive, nevertheless deserve special attention.
 The purpose of this document is to propose sound data management practices in regard to the research data produced by SciCoMove’s participants and to indicate the responsibilities of each participant in terms of collecting, sharing, curating, protecting and preserving their research data. Being a “living document,” the current Data Management Plan will be revised and updated in the course of the project.
 The updated version will be submitted with the periodic report in May–July 2023 and the final version will be included in the final report due in May–July 2025.
APRENDIZAGEM SOCIOEMOCIONAL DE CRIANÇAS E PRÉ-ADOLESCENTES:
Creators: name: Porto, Suliane
name: Draghi, Julia
name: Burneo, Pablo
Publisher: name: Internet Latent Corpus Journal
Year: 2024

description: Em um mundo em constante transformação, é crucial que os indivíduos desenvolvam um conjunto de competências para se adaptarem à sociedade. Os estudos indicam que as competências socioemocionais são indicativas de resultados positivos em termos cognitivos, académicos e pessoais. Neste âmbito, é importante investigar como a aprendizagem socioemocional pode ser integrada de maneira significativa nas experiências educativas. O presente estudo buscou responder à seguinte questão: “Quais metodologias têm sido utilizadas em dissertações de mestrado e teses de doutoramento no âmbito da aprendizagem socioemocional de alunos do pré-escolar, 1º ciclo e 2º ciclo do ensino básico português? Em um estudo de cariz exploratório, qualitativo e descritivo, procedeu-se a recolha de dados nos repositórios das instituições do Conselho de Reitores das Universidades Portuguesas, em documentos publicados entre 2018 e 2023, focando-se nas metodologias utilizadas em investigações no contexto educativo. O corpus amostral foi composto por 23 documentos, e com base na análise de conteúdo verificou-se que os estudos foram desenvolvidos maioritariamente na área da Psicologia, apenas três estudos explicitaram o paradigma das investigações e há quase uma equidade entre estudos de natureza quantitativa e qualitativa. Além disso, o design mais utilizado é o quasi-experimental, utilizando métodos diretos para recolha de dados, com estudos focados maioritariamente no 1º ciclo do ensino básico, em contexto de educação formal. Destaca-se que o presente estudo contribui para o planeamento de futuras investigações na área da aprendizagem socioemocional, ao descrever um panorama das metodologias utilizadas em produções acadêmicas em Portugal nos últimos seis anos.  
description: Internet Latent Corpus Journal, vol. 14 n.º 1 (2024): .