cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pretrial diversion & record sealing
Creators: name: Chaple, Michael James
Publisher: name: No Publisher Supplied
Year: 2011

description: Pretrial diversion programs, which provide treatment and other ancillary support, have consistently demonstrated an ability to reduce recidivism forsubstance abusing offenders. However, prior research has almost always overlooked the fact that diversion programs have the potential to promote recordsealing, and therefore the effect of record sealing on recidivism has rarely been studied. The current study compared re-arrest rates for two groups of a first-time,substance-abusing, nonviolent felony offenders—those convicted versus diverted to treatment in lieu of conviction. Results from the path analysis show that theeffect of criminal justice disposition (i.e., diverted vs. convicted) on recidivism is in fact mediated by record sealing. Specifically, being convicted actuallyincreased the odds of re-arrest because being convicted decreased the odds of record sealing and getting a record sealed decreased the odds of re-arrest.Overall, results point to the importance of record sealing in suggesting that the success of these competing dispositions (i.e. conviction vs. diversion) depends largely upon the extent to which they can facilitate record sealing. Evidence from this study suggests that diversion currently offers the best path to record sealing.Criminal justice policy makers should give more consideration to the potential benefits that may be realized by implementing strategies designed to promote record sealing for first-time, substance-abusing, nonviolent felony offenders.
IL-12 genetic immunotherapy for lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer death in men and women in the United States. New therapies are needed for lung cancer to either prevent or treat its spread throughout the body. This research focuses on boosting the immune system against lung cancer by using specialized immune enhancing cells called dendritic cells. This new form of therapy uses dendritic cells that are removed from the blood, activated in test tubes, and then injected into lung tumors. This type of therapy is able to completely cure mice with cancer. In order to develop dendritic cell immunotherapy for patients with lung cancer, this research focuses on determining how this therapy works in mice with lung cancer. This is research that can be translated from laboratory studies into clinical trials in patients with lung cancer. Thus, results of this study may have a major impact on the treatment of lung cancer.
Globalization and immigration in an Irish community
Creators: name: Biroc, Frances B.
Publisher: name: No Publisher Supplied
Year: 2011

description: The benefits and shortfalls of contemporary global processes are evident in Ireland’s recent history, and they continue to impact all segments of Irish society. On January 3, 2009, an Irish Times editorial titled “No Time for Whingers” declared that in Ireland, “We have gone from the Celtic Tiger to an era of financial fear with the suddenness of a Titanic-style shipwreck thrown from comfort, even luxury, into a cold sea of uncertainty.” There is a saying that the market is driven by two emotions, greed and fear, and in Ireland while the Celtic Tiger flourished, greed and the desire for immediategratification fueled the economy. In today's economic climate fear and uncertainty abound. While acknowledging that integration and social inclusion are global issues, this project focuses on the extent of social inclusion experienced by immigrants in an Irishcommunity and examines the responses of the host population to the recent influx of immigrants. Social inclusion defined herein as a person’s ability to participate in community affairs, to enjoy adequate housing, employment and education. The research does not seek a scientific measurement to illustrate the extent to which social inclusion has been achieved in the area. The goal is to capture the feelings and the perceptions of the local population regarding the extent to which different segments of the populationare socially mobile.
Effect of tobacco smoke on nitric oxide synthesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking may lead to hypertension and stroke due to the decreased ability for the body to synthesize nitric oxide (NO). NO is a small molecule which has been implicated in a variety of physiological processes. One of its more important functions involves the relaxation of blood vessels. NO has been shown to dilate blood vessels and thus, allow more blood to flow. The human body takes advantages of this system to regulate the amount of blood flow to various parts of the body by adjusting the amount of NO produced. NO is also involved in the thinning of the blood by decreasing the stickiness of blood platelet cells. This process decreases the chance of these cells forming aggregates which may block small arteries and lead to strokes.

 NO is produced in the body by an enzyme called nitric oxide synthase (NOS). NOS produces NO from L-arginine, one of the 20 essential amino acids. When NOS does not function property, hypertension can occur since the blood vessels are more constricted. Also, there is an increased chance of stroke because of these narrow vessels and thickening of the blood. It is by this process by which we believe that smoking can cause hypertension and strokes.

 It has been shown by us and other investigators that components of cigarette smoke can react with L-arginine to form an L-arginine adduct. This reaction may have two possible effects. First, it may decrease the amount of L-arginine in the body and thus, less NO is produced since there is less of its precursor. Secondly, the adduct formed may bind to the NOS itself and inhibit its function. In order to investigate these possibilities further, both cultured cells and laboratory animals will be exposed to cigarette smoke. Afterward, levels of L-arginine and its possible cigarette smoke adduct will be measured and correlated with possible decreases in NOS function. The benefits of such a study include not only establishing a link between smoking and various cardiovascular diseases, but also a possible treatment program for smokers who may be hypertensive through L-arginine replacement therapy.
Thiamin diphosphate catalysis in Escherichia coli pyruvate dehydrogenase multi-enzyme complex
Creators: name: Balakrishnan, Anand
Publisher: name: No Publisher Supplied
Year: 2011

description: Spectroscopic identification and characterization of covalent and non-covalent intermediates on large enzyme complexes is an exciting and challenging area of modern enzymology. While nuclear magnetic resonance (NMR) methods which provide detailed chemical insights have been successfully employed previously, limited examples are available in the literature for large enzyme complexes. Enzymes utilizing cofactors provide promising examples for such studies when synthetic routes to labeled cofactor analogs and protocols for reconstitution of apo-enzymes with such analogs are readily available. Syntheses of key isotope enriched thiamin diphosphate (ThDP) analogs – [C2, C6’ – 13C2] ThDP, [N4’ – 15N]ThDP and [C2 – 13C]ThDP – enabled first detection of (i) various ionization/tautomerization states of ThDP during the catalytic cycle of three ThDP dependent enzymes using cross polarization magic angle spinning (CPMAS) solid state NMR (SSNMR) spectroscopy and (ii) [C2, C6’ – 13C2] ThDP covalent intermediates on the E1 component (E1p) during the catalytic cycle of E. coli pyruvate dehydrogenase multi-enzyme complex (PDHc) by filter experiments including solution 1-D 1H-13C HSQC NMR. Direct evidence was gathered for the 4’-aminopyrimidinium form (APH+) on ThDP molecules bound to (i) S. cerevisiae yeast pyruvate decarboxylase (YPDC) (ii) E1p and (iii) the E1 component of E. coli 2-oxoglutarate dehydrogenase complex (E1o) using 13C and 15N CPMAS SSNMR. The thiazolium C2-H bond was found to be slightly acidic in the cofactor bound to these enzymes. 15N SSNMR experiments confirmed the formation of the 1’,4’-iminopyrimidine tautomer in presence of substrate analogs; a mechanism is proposed for the stabilization of this biologically rare tautomer in enzyme active-sites. Using rapid chemical quench in conjunction with solution NMR, pre-steady state analyses were performed on the native PDHc and PDH complexes reconstituted with E1p active-site loop variants of very low PDHc activity. The C2-α-lactylThDP intermediate could not be detected under any of the conditions used, indicating that its formation is slower than its decarboxylation. The enamine intermediate accumulates at a rate 110 s-1 on E1p and PDHc, while the rates are 100-fold slower for the PDHc variants. 2-acetylThDP could be detected on E1p only during its reaction with pyruvate and the artificial electron acceptor DCPIP. Reductive acetylation of the lipoyl domain in a pre-steady state single turn-over experiment (a model for the E1p-E2p reductive acetyl transfer reaction) was determined by mass spectrometry. Combined, these kinetic results from artificial oxidation reactions suggest the enamine is very well stabilized by E1p and oxidation of the enamine and substrate channeling to E2p are favored by intact PDHc. These studies provide unprecedented insight into the acid-base and covalent electrophilic roles of ThDP in enzyme catalysis and the methods described herein are applicable to all such complexes.
Fanning the flames
Creators: name: Adubato, Beth
Publisher: name: No Publisher Supplied
Year: 2011

description: Images of athletes as criminal suspects seldom shock society; newspapers run “police blotters” in their sports sections. “Doping” presents a serious problem amongOlympians, professional team players, and even cyclists of the Tour de France. Sports fans across Europe, Asia, and South America have wreaked deadly havoc on each other after soccer matches. With all of these obvious associations, criminology still lags behind psychology in the inclusion of the study of sports within its purview. Throughout the rest of the world, much of the sports/crime focus is on the fans—so-called “hooliganism.” This dissertation attempts to address a sports/crime issue in the United States,while largely availing itself of these European hooligan studies. The issue at-hand is whether televised, professional, American football games affect domestic violence. The purpose of this study is to not only examine possible correlation between these twoevents in one geographical area (namely Philadelphia), but further, to possibly influence sports/crime study in the field of American criminology. A good deal of research into “hooliganism” attributes the behavior to the concept of BIRGing or “Basking in Reflected Glory.” This concept provides much insight into the “highly-identified” sports fan. It is these highly-identified sports fans that this dissertation presumably examined. Most specifically, does the highly-identified sports fan feel a strong bond with his favorite football players and imitate their behavior? Do televised football games bring about copycat, violent behavior? Using the copycat framework, this dissertation research looked at domestic violence arrests in the city of Philadelphia on the days that Eagles games were played, for an eight-hour period, beginning with kick-off time. These relationships were tested using comparison of means tests—both theLevene test and the Mann-Whitney tests. As predicted, there was no difference between the mean average of holidays and football gamedays, This hypothesis was specifically designed to compare football gamedays to those days highly-connected to alcohol consumption. Also as predicted, there was no statistically significant difference between home games and away games, taking away the possible bias that fans were at the game and then became violent, as opposed to watching the game on television. The meanaverage of domestic violence arrests on football was statistically significantly different from both comparison Sundays and other sports’ gamedays. This study could be expanded to include more years and/or replicated in another city. This study addresses the media hype and misconceptions surrounding football and domestic violence and challenges criminology to expand its field to include sports and crime.
Ophidiidae Rafinesque 1810
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Ophidiiformes
Ophidiidae

description: Ophidiidae indet.
Material examined
UNITED STATES OF AMERICA – Alabama • 11 otoliths; GLS otolith comparative collection (10 specimens), MSC 39042.12.
Description
Several characteristics point to the family Ophidiidae for these specimens. These features include the sulcus, ostium, cauda, and general shape. Unfortunately, the preservation of the specimens prohibits any further, more specific identification.
Remarks
These specimens could belong to an ophidiid species already described from the Claiborne Group of Alabama or could represent a different species. Preservation does not allow this determination.
Stratigraphic and geographic range in Alabama
All of the specimens of Ophidiidae indet. were derived from the “upper” Lisbon Formation at site ACh- 7 except for one specimen (MSC 39042.12) which was collected from the Gosport Sand at site AMo-4. Bartonian, zones NP16 and NP17.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 203, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Effects of PSA content and formal features on smoking norms
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: To effectively discourage youth smoking, antismoking public service announcements (PSAs) must be attention-getting, provocative, engaging, memorable, as well as illustrate convincing reasons not to smoke. Considerations of how ads look (form) and what they say (content) are critical to developing antismoking PSAs. However, scientific studies provide little information that guides decisions about effective message design. Thus, the proposed addresses an important research question: How do the form and content of antismoking PSAs affect young people's attitudes towards the ads themselves and (more importantly) the health-relevant behaviors they advocate?

 The proposed research is concerned with testing the effects of two characteristics of antismoking PSAs, content and formal features. Content will be examined by comparing PSAs that focus on the behavior ofsmokers (illustrating negative consequences of smoking and second-hand smoke) and PSAs that focus on the behavior of the tobacco industry (exposing deceptive marketing tactics of tobacco manufacturers). This distinction between PSAs that focus on individual smokers versus the tobacco industry is important because existing research is uncertain as to which content theme more effectively discourages tobacco use and denormalizes smoking.

 Apart from content, PSAs also vary in appearance -- the combination of editing, pacing, music, use of color or black-and-white, and close-up shots, that create the "look and feel" of the message. The effect of these formal features will be examined by comparing complex ads (many edits, fast-paced, different camera angles, much movement, facial close-ups) and simple ads (few edits, slow-paced, few camera angles, little movement, distant shots). Studying the effect of formal features is important because these attributes have been shown to influence memory and evaluation of ads for commercial products and political candidates.

 The proposed research would: (1) examine the content of current antismoking PSAs gathered from several states and Canada; (2) assess audience reaction to these ads in a pilot study with young adults; and (3) conduct an experiment to examine the effects of content (individual vs. industry) and formal features (simple vs. complex) on ad specific outcomes (memory, liking, involvement, interest) and health relevant outcomes (antismoking attitudes and norms). This research would contribute to California prevention efforts by demonstrating which combination of formal features and content make antismoking PSAs most memorable, believable and, therefore, effective.
An analysis of the listening preferences of elementary school children  for Western classical art music in the orchestra setting
Creators: name: Richardson-Melech, Joyce S.
Publisher: name: No Publisher Supplied
Year: 2011

description: The scope and volume of research of music preference is vast with a strong tradition in music education. Many studies examine particular musical factors such as tempo, volume, timbre, genre, style, and performing medium. Many educational and social factors have beeninvestigated as well, such as gender, age, influence of peers, influence of adults, popularity, and familiarity. Despite the number of studies concerned with music preference, there appears to be little or no documentation on the effects of concert preparation on the students’ listening preferences for Western classical art music. The purpose of the proposed study was to determine if the students’ participation in pre-concert lessons designed by the Master Teachers’ Collaborative of the New Jersey Symphony Orchestra has any effect on influencing the Western classical artmusic listening preferences of students. Qualitative and quantitative methods were used to analyze third grade students’ (N = 74) listening preferences for Western classical art music. A pre-test, treatment, posttest design was employed, supplemented by student interviews, surveys, questionnaires, field notes, and journaling. Both pre- and post tests consisted of a listening preference test based on the orchestra concert program the students were to attend. The treatmentconsisted of lessons intended to direct the students in their listening to Western classical art music performed by an orchestra. There was a highly significant increase in the general population for Listening Example 3 with a p value of < .01. It was also found that there was asignificant difference between the listening preferences of male and female subjects for the Listening Example 3 (Movement 3 from Scheherazade, Festival at Baghdad – The Sea –Shipwreck from Nickolay Rimsky-Korsakov, Scheherazade/Capriccio espagnol recorded by The Boston Symphony on Deutsche Grammophon CD# 289 469 659-2). Male subjects showed a significant increase for Listening Example 3 in the posttest with a p value of < .05. Female subjects rated the Listening Example 3 highly in both the pretest and in the posttest, showing a significant increase with a p value of < .05. Interviews conducted revealed that the subjectsrecollected events in the concert visually rather than musically. The majority of subjects interviewed claimed that the pre-concert lessons were helpful in helping them prepare for the concert experience. An unexpected result emerged in that the listening preference for 8-year-olds declined for Listening Example 2 while the listening preference for 9-year-olds increased. It ishoped that this study will serve as an impetus for further research in this area.
Importance of Rce1 and Ras in tobacco-induced cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the most devastating tobacco-related diseases is lung cancer. In normal cells and tissues, Ras proteins are responsible for transmitting signals for cell division and growth. In many lung cancers, it is possible to detect an activating mutation in one of the Ras proteins. Specific mutations in the Ras proteins can activate this signaling process, resulting in continuous and uncontrolled filled cell division. This uncontrolled cellular growth is one of the steps in the development of cancer.

 The Ras proteins undergo three different processing events that are crucial for the proper localization and function of these proteins within the cell. The first step, the attachment of a lipid (a type of fat molecule) to these proteins, has been shown to be extremely important for Ras function. One class of drugs inhibits the addition of a specific lipid to Ras proteins and has been shown to retard the growth of cancers in animal models. However, some recent observations suggest that these drugs may not be effective in preventing the growth of all Ras-induced cancers.

 The second processing step involves the removal of the last three amino acids from the Ras proteins. Our laboratory has been studying a mouse gene, Rce1, which is involved in that processing step. Our laboratory has generated mice that lack the Rce1 gene, from which we have cultured cells that lack Rce1 and demonstrated that Ras processing is blocked in those cells. Also, we found that the Ras proteins are not properly localized within cells lacking Rce1. We have hypothesized that the abnormal location of the Ras proteins within cells may prevent their normal function. If this is the case, blocking Rce1 function might prove to be a very reasonable target for anticancer drug therapy.

 During my fellowship, I will determine whether the blockade of Rce1 function is a reasonable target for treating Ras-induced cancers. The first aim of this proposal is to fully characterize liver-specific Rce1 function in an animal model. The second aim will be to assess the role of Rce1 in a normal cellular proliferation event; i.e., liver regeneration, which is thought to depend on the Ras signaling pathway. The third aim will be to compare the growth of Ras-induced cancers in nice with normal Rce1 expression and in mice that lack Rce1 gene expression in specific tissues. It will be very interesting to determine if smaller and/or fewer tumors are produced in the absence of Rce1. If cancer growth is retarded in the absence of Rce1, then blocking this pathway might be a useful strategy for retarding the growth of Ras-induced cancers in humans. This work is highly relevant to tobacco-related disease, since many human lung cancers have activating mutations in one of the Ras proteins.
Gobiidae Ebersole, Cicimurri & Stringer, 2019, indet.
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Gobiidae

description: Gobiidae indet.
Fig. 70 O–P
Material examined
UNITED STATES OF AMERICA – Alabama • 1 otolith; MSC 39045.
Description
Small otolith measuring 2.1 mm in length, roughly trapezoidal in shape. Inner face primarily smooth (except for depression at dorsal area), convex. Margins smooth, sharp in transversal view. Anterior margin ranging from almost straight to slightly incurved.Anterodorsal unevenly rounded. Dorsal margin only slightly rounded, subparallel with ventral margin. Posterodorsal is characterized by small rounded projection. Posterior incurved. Ventral margin almost straight, horizontal. Well-defined, divided sulcus slants slightly from posterodorsal to anteroventral. Ostium about twice as long and twice as wide as cauda. The ostium oval in shape, much more excavated than cauda. Ostium almost touches anterior margin. Posterior of cauda rounded. Ridge-like crista superior located above sulcus. Prominent, deeply depressed area in dorsal area touches crista superior. Crista inferior is small, ridge-like structure beneath cauda and posterior of ostium. Outer face smooth, convex, thickest at approximately center but thinning towards margins.
Remarks
The oldest known possible gobiid otolith occurred in middle Ypresian strata of India (Nolf et al. 2006). Gobiid otoliths are quite rare in all known assemblages until the late Eocene. Nolf & Stringer (2003) noted 57 specimens of gobiids (“genus Gobiidarum ” vetustus) from the upper Eocene Yazoo Clay of Louisiana. We believe that the Lisbon Formation gobiid represents a different species from the Yazoo Clay taxon because of the significant differences between the shape of the otolith sulci, but a larger Lisbon sample is needed to corroborate our observation.
Stratigraphic and geographic range in Alabama
The single gobiid specimen was recovered from the “upper” Lisbon Formation at site ACh-7. Bartonian, zones NP16 and NP17.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 204, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Study of novel metastasis inhibitors in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is a particularly aggressive form of cancer: It is the leading cause of cancer death in the United States, and the majority of patients present with advanced disease for which surgery is not an option. Metastasis, the process whereby tumor cells spread to distant organs via the bloodstream, contributes a large part of the morbidity and mortality of lung cancer. Metastasis is also associated with the vast majority of lung cancer treatment allures, and drugs aimed at inhibiting this process have great potential in both halting disease progression and modifying response to current therapy.

 This project targets important steps in lung cancer metastasis. There are certain adhesion molecules (those that contain sugar, a.k.a. "glycosides") which assist metastatic cells in binding to blood vessels of distant organs, once they are free from the primary tumor. A class of adhesion molecules which may serve a vital role in this process is known as selectins. Their presence on the inner lining of blood vessels throughout the body may facilitate lung tumor cells (bearing the corresponding "ligand" molecules, much like a "lock and key") in attaching to blood vessels in the brain, liver, bones, or to other parts of the lungs – common organs to which lung cancer spreads. Research has also shown that platelets, which are normal clotting elements of blood, may facilitate this process by using the same molecules to mediate platelet-tumor cell adhesion. In distant blood vessels, such tumor cell-bound platelets may assist in tumor cell attachment and eventual uptake.

 The proposed research is aimed at the above tumor ligand molecules, and specifically at disrupting their sugar-molecule structure by treating tumor cells with a new class of drugs that impair the cell's sugar-making machinery. Tumor cells treated with such compounds lack the ability to bind platelets or blood vessel inner-lining cells; and thus these inhibitors have potential as anti-metastatic drugs. To date, no studies have examined lung cancer cells treated with such agents. We are initially examining if these agents affect the ability of lung tumor cells to bind donated human platelets and to cultured blood vessel-lining cells. Subsequent animal studies will include simulated metastasis models under humane treatment conditions; and as pharmacology develops, techniques to examine tumor growth /metastasis in inhibitor-treated mice are planned. Ultimately, such agents have potential as anti-metastatic agents in human lung cancer.
Prasoxylon klanderi Mabb. & Holzmeyer 2021, comb. nov.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Prasoxylon
Prasoxylon klanderi

description: 4. Prasoxylon klanderi (F.Muell.) Mabb. & Holzmeyer, comb. nov.
≡ Dysoxylum klanderi F.Muell., Fragm. 5: 176. 1866 – Syntypes: Australia, Queensland, Rockingham Bay, Dallachy s.n. (MEL, several sheets).
Distribution. – NE Australia.
Note. – See also Mabberley (2013b: 30).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1266, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Dynamics of state tobacco control making
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Not long ago, tobacco agreements were approved by all fifty state attorney generals and the tobacco industry. This situation created wide curiosity about how the state governments will choose to use their large amount of new funding. This project will look at how California and Florida will now spend their funds on anti-smoking programs. It will also look at tobacco control programs in New Jersey, Washington, Mississippi, and Missouri. In California, the Democrats have now taken control of the governor's mansion. In the past in California, the Republicans controlled the governor's mansion. Florida has the opposite situation. In the past, the Democrats controlled the governor's mansion. Now, the Republicans control the governor's mansion. In Missouri, New Jersey, Washington, and Mississippi, there has been no change in political party in the governor's mansion. Each of these states are in different parts of the country and have governors of different political parties. Each of these states already have small anti-smoking efforts. They have not yet set up a major statewide anti-smoking effort.

 In order to accurately understand how anti-smoking efforts will take place in these states, this study will look at whether the anti-smoking advertising effort done by a state named the tobacco companies and showed that they were a big cause of smoking; if the anti-smoking funds were used for other purposes such as health care for the poor; if the anti-smoking efforts were slowed down or stopped because different government agencies were clashing in the way they ran the anti-smoking effort; if the anti-smoking effort had a correct and true way to be looked at and judged; and if the anti-smoking program involved just youth or both youth and adults. Because Missouri, New Jersey, Washington, and Mississippi have not set up major statewide anti-smoking programs yet, this study will also look at their anti-smoking funding efforts after they set up the programs in the near future.

 One important part of this study will be looking at what ways state legislatures will assist or even change the way governors spend the new funds on anti-smoking programs and for what reasons. State legislatures can do this by passing budgets, making new laws, or by calling government employees to hearings to explain how they are using the anti-smoking money.
Bothidae Smitt 1892
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Pleuronectiformes
Bothidae

description: Bothidae indet.
Fig. 70 Q–R
?“genus Citharidarum ” sulcatus – Nolf & Stringer 2003: 4, pl. 8, figs 10–11b.
Material examined
UNITED STATES OF AMERICA – Alabama • 1 otolith; MSC 42235.
Description
Ovate specimen very small, measuring approximately 2.0 mm in length. Inner face flat to very slightly convex. Margins smooth. Anterior margin bluntly rounded, anterodorsal also slightly rounded. Dorsal slightly slanted, almost straight. Posterodorsal tapered but rounded. Ventral margin regularly curved. Divided sulcus having approximately parallel margins. Sulcus extends from anterior margin about 75% of otolith length. Sulcus may be very slightly inclined toward dorsal. Ostium and cauda difficult to determine but appear to be about equal in length (ostium possibly slightly longer). Width of ostium and cauda also approximately equal. Crista superior located above sulcus. Longitudinal depressed areas occur just above and below sulcus. Poorly defined depressed dorsal area. Ventral furrow appears to be present. Outer face slightly irregular, ranging from almost flat to slightly convex.
Remarks
The Lisbon Formation specimen exhibits some similarity to “genus Citharidarum ” hoffmani from the upper Eocene Yazoo Clay of Louisiana (Nolf & Stringer 2003), but additional material from the Lisbon Formation is needed for more meaningful comparisons.
Stratigraphic and geographic range in Alabama
The one bothid specimen was found in the “upper” Lisbon Formation at site ACh-8. Bartonian, zones NP16 and NP17.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on pages 204-205, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Prasoxylon angustifolium Mabb. 2021, comb. nov.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Prasoxylon
Prasoxylon angustifolium

description: 5. Prasoxylon angustifolium (King) Mabb., comb. nov. ≡
Dysoxylum angustifolium King in J. Asiat. Soc. Bengal, Pt. 2, Nat. Hist. 64: 39. 1895 – Holotype: Malaysia, Pahang, Sg. Tahan, Ridley 2656 (CAL barcode CAL0000006801 [image!]).
Distribution. – Eastern Peninsular Malaysia.
Notes. – See also Mabberley (2013a: 197). The only rheophytic “ Dysoxylum ”.
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1266, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Membrane proteins and TGF-alpha/EGFR: a role in lung cancer?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Communication between different parts of the body is required for proper function. This communication is precisely controlled and its deregulation results in many diseases. It has been well established that long-term cigarette smoking causes a number of illnesses, including lung cancer. Among all the possible causes, cigarette smoking (either first hand or second hand) accounts for 85%-90% of lung cancer cases. However, much remains to be discovered regarding how the components in tobacco cause the deregulation of bodily communication that leads to cancerous transformation of lung tissue.

 In many cases, cell communication is mediated by small protein molecules called growth factors. Protein growth factors are important regulators of the growth and function of cells in the lung. One of the important growth factors is transforming growth factor alpha (TGF-a), which is the growth factor I will investigate. TGF-a can change a cell's behavior, making it grow or specialize, by binding to another unique protein (a receptor called EGFR) on the cells' surface. When a cell no longer responds to growth factors or overproduces growth factors and/or their receptors, this cell may undergo uncontrolled growth that results in tumor formation. Strong evidence suggests that TGF-a is involved in both the normal growth of lung epithelial cells and its cancerous transformation. The over-production of TGF-a and related growth factors can initiate cancerous transformation from normal lung cells to malignant state. Interestingly, cancerous lung cells also produce elevated levels of TGF-a.

 Even though we believe that TGF-a plays important roles in both normal and disease states of lung tissue, much remains unknown about how TGF-a participates in regulating the cancerous transformation of normal lung cells. The change in cell behavior caused by TGF-a and EGFR is a complicated process. This proposal is aimed at characterizing two proteins (CD9 and hRho) that are associated with TGF-a/EGFR and are believed to be important regulators in TGF-a/EGFR signaling pathways. We plan to conduct a series of biochemical studies designed to accomplish two aims: (1) To investigate the consequences of CD9/TGF-a binding on cell morphology, cell adhesion and cell polarization, all of which undergo changes during cancerous transformation; (2) to characterize the structural and biochemical bases of the interaction between hRho and TGF-a/EGFR in order to learn more about how this interaction regulates cell growth and differentiation. Research on how TGF-a affects lung cell behavior in both normal and disease states will help us to better understand the role of TGF-a in the progression of lung cancer. Ultimately, this may help us design new ways to prevent and control the lung cancer in the future.
Prasoxylon hongkongense Mabb. 2021, comb. nov.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Prasoxylon
Prasoxylon hongkongense

description: 6. Prasoxylon hongkongense (Tutcher) Mabb., comb. nov. ≡
Chisocheton hongkongensis Tutcher in J. Linn. Soc. Bot. 37: 64. 1905 ≡ Dysoxylum hongkongense (Tutcher) Merr. in Lingnan Sci. J. 13: 33. 1934 – Holotype: China, Hong Kong Is., Mt Parker, Tutcher, Herb. Hong Kong Bot. Gard. 969 (K [over two sheets] barcodes K000657056! & K000657057!).
Distribution. – Southern China.
Note. – See also Peng & Mabberley (2008: 126).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1266, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Biculturalism
Creators: name: Patterson, Allene
Publisher: name: No Publisher Supplied
Year: 2011

description: Bicultural theories can help us understand people who experience bicultural or multicultural situations. This is important because a shared cultural understanding will allow us to be more comfortable in our own culture and to adapt to the expectations of others. This process is experienced as a personal journey to recover and stabilize with one‟s own identity. Consequently, some kind of resolution is the outcome. This essay will analyze literature that is written by two culturally diverse authors, Leslie Marmon Silko and Maxine Hong Kingston to learn of the social and cultural consequences of bicultural experience. The protagonists must first understand their own cultural heritage in order to attain ethnic identity. Their conflicts become the basis for selfhood. I will explain how these authors use myths, talk stories, landscape and family to theorize and articulate multicultural identity.
Pseudocarapa Hemsl.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Pseudocarapa

description: VI. Pseudocarapa Hemsl. in Hooker’ s Icon. Pl. 15: 46. 1884 –
Type: Pseudocarapa championii (Thwaites) Hemsl. ≡ Dysoxylum championii Hook.f. & Thomson ex Thwaites.
Distribution. – Five species from Sri Lanka to New Guinea.
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1266, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Developing a dynamic digital twin at a building level: Using Cambridge campus as case study
Creators: name: Vivi, QL
name: Parlikad, AK
name: Woodall, P
name: Ranasinghe, GD
name: Heaton, J
Publisher: name: ICE Publishing
Year: 2019

description: A Digital Twin (DT) refers to a digital replica of physical assets, processes and systems. DTs integrate artificial intelligence, machine learning and data analytics to create dynamic digital models that are able to learn and update the status of the physical counterpart from multiple sources. A DT, if equipped with appropriate algorithms will represent and predict future condition and performance of their physical counterparts. Current developments related to DTs are still at an early stage with respect to buildings and other infrastructure assets. Most of these developments focus on the architectural and engineering/construction point of view. Less attention has been paid to the operation & maintenance (O&M) phase, where the value potential is immense. A systematic and clear architecture verified with practical use cases for constructing a DT is the foremost step for effective operation and maintenance of assets. This paper presents a system architecture for developing dynamic DTs in building levels for integrating heterogeneous data sources, support intelligent data query, and provide smarter decision-making processes. This will further bridge the gaps between human relationships with buildings/regions via a more intelligent, visual and sustainable channels. This architecture is brought to life through the development of a dynamic DT demonstrator of the West Cambridge site of the University of Cambridge. Specifically, this demonstrator integrates an as-is multi-layered IFC Building Information Model (BIM), building management system data, space management data, real-time Internet of Things (IoT)-based sensor data, asset registry data, and an asset tagging platform. The demonstrator also includes two applications: (1) improving asset maintenance and asset tracking using Augmented Reality (AR); and (2) equipment failure prediction. The long-term goals of this demonstrator are also discussed in this paper.
Lactarius Valenciennes 1833
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Lactariidae
Lactarius

description: Genus Lactarius Valenciennes, 1833
Type species
Lactarius delicatulus Valenciennes, 1833 in Cuvier & Valenciennes 1833, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 205, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Life on the boundary
Creators: name: Moses, Raven Marlenia
Publisher: name: No Publisher Supplied
Year: 2011

description: With the advent of various state laws that classified as black any individual with at least “one-drop” of African blood and the legalization of racial segregation enacted by the Plessy vs. Ferguson Supreme Court decision, the American post-Reconstruction era was a period in which the line separating races became more and more distinct. However, as the legal definitions and hierarchical categorizations of racial difference became more discrete, the physical basis of racial distinction became increasingly destabilized. Nella Larsen’s Passing and James Weldon Johnson’s The Autobiography of an Ex-Coloured Man are novels from this period that depict the struggles of characters who suffer because of the social and legal distinction between “black” and “white.” Because of the socialimperative that these characters be black even though they have visibly white skin, the distinction between “black” and “white” actually becomes an arbitrary distinction between “white” and “not-white.” The protagonists of both novels--Clare Kendry, IreneRedfield, and the unnamed Ex-Colored Man--all seek stable self-definitions that successfully integrate both their personal and social identities. However, because of their inability to resolve the paradox created by their visible “whiteness” and legal classification as “black,” none of the protagonists are able to successfully negotiate the threats posed by their racially and socioeconomically oppressive environment whilekeeping their personal identities continuously intact. Unable to form stable, coherent identities through the blending of mutually agreeable public and private “selves,” Clare, Irene, and the Ex-Colored Man remain in irresolvable positions with identities that arepermanently indeterminate.
GIESEPP MP project webinars
Creators: name: WIT Berry
Publisher: name: Zenodo
Year: 2025
Subjects: Electric space propulsion

description: This document contains information about the project-organised and co-organised webinars and speakers as well as information about the presentations and links to recorded webinars that are posted online. 

Webinars

Electric Space Propulsion & new career opportunities in the space sector in Europe (17.11.2021) 

Electric space propulsion (24.05.2023) 

Unlocking Opportunities: Collaborating with Industry leaders in space sector (21.11.2023)

The final results Horizon 2020 project GIESEPP MP (20.11.2024)
Hemingway
Creators: name: Mullaney, Michael
Publisher: name: No Publisher Supplied
Year: 2011

description: This capstone discusses the possible reasons for the virtual absence of any college class curricula devoted to or including the works of Ernest Hemmingway. Hemingway was the recipient of the Pulitzer Prize, a Nobel laureate in Literature, and an author whose writing talent in his early years garnered the praise and literary master recognition of other iconic literary figures of his time like Ezra Pound, Gertrude Stein, James Joyce, F. Scott Fitzgerald and Sherwood Anderson. This capstone will examine the Hemingway legacy both in his perceived hedonistic lifestyle and misogynic labeled writings and formulate an argument that might explain why, despite recent decades of critical reviews revising the negative myths of his legends and literature, the study of Hemingway‟s art is rarely found in the majority of college curricula.