cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pre-print: Predictors of cold and pressure pain tolerance in healthy South African adults. DOI: 10.1093/pm/pnw291
Creators: name: Leeana Persad
name: Kamerman, Peter
name: Wadley, Antonia
Publisher: name: figshare
Year: 2017
Subjects: Behavioral Neuroscience
Neuroscience and Physiological Psychology

description: Pre-print copy of: Bagwath Persad LA, Kamerman PR, Wadley AL. Predictors of cold and pressure pain tolerance in healthy South African adults. Pain Medicine [Epub ahead of press], 2017. DOI: 10.1093/pm/pnw291, PMID: 28082523
Dataset and analysis scripts: 10.6084/m9.figshare.2289385

Abstract: Background: Studies on relationships between sex, ethnicity and pain largely have emanated from the US and Europe. We compared cold (CPT) and pressure pain tolerance (PPT) in male and female South Africans of African and European ancestry and assessed whether psychosocial factors (including pain beliefs) predicted differences in pain tolerance. Methods: We recruited 106 (62 female) students of African ancestry and 106 (55 female) of European ancestry and subjected them to a cold-pressor test and pressure algometry. Socioeconomic status (SES), pain catastrophizing, depression, anxiety and pain beliefs were assessed as predictors of differences in pain tolerance. Results: CPT was lower in students of African compared to European ancestry (for both sexes), and PPT was lower in female than male students (for both ethnicities). Men were less accepting of men expressing pain than were women, with males of African ancestry being least accepting. Multivariate analysis identified that being of African ancestry, and particularly a female of African ancestry predicted lower CPT. Anxiety was of borderline interest. Sex was the only significant predictor of PPT on multivariate analysis (PPT females < males) and catastrophizing was of borderline interest. Female sex and African ancestry were important predictors of acceptance of expression of pain in males. SES was a variable of interest. Conclusions: Despite a different cultural and social background from US and European cohorts, we saw similar patterns of sex and ethnic differences in CPT and PPT in an African cohort. Traditional psychosocial predictors of pain sensitivity were identified as being of interest but were not strongly associated.
Analyses
Creators: name: Tangen, Jason M
name: McCarthy, Duncan
name: Linzi Wilson-Wilde
name: Corbett, Brooklyn
name: Raymond, Jennifer
name: Robson, Samuel G.
name: Osborn, Scott
name: Hayes, Robert
name: Cavallaro, Anneliese
name: Edmond, Gary
name: Eva, Kevin
name: Byard, Graham
name: Searston, Rachel A.
name: Thompson, Matthew B
Publisher: name: OSF Registries
Year: 2018

description: This component includes our complete data analytic pipeline: from raw individual .txt files to final R Markdown plots and analyses. The "analysis folder" contains data files (.txt) for 12 simulated novice participants and 12 simulated expert participants with pseudorandomly generated response data—these are used to test out the experimental analysis script, and model the null (e.g., what we'd expect to see in our data due to chance; see the simdata.jpeg plots as illustration). Also included is a LiveCode data extraction tool for aggregating raw data from the individual .txt files, an R Markdown folder with source code, and a fully documented html file documenting all code, notes, plots and results of statistical analyses. A 'final analysis' folder will be uploaded here once data collection is completed and the genuine human has data been thread through this general data analytic pipeline.
"Attitudes of customers towards the financial institutions-A comparison between private commercial banks and nationalized commercial banks in Bangladesh with implications of Fishbein model."
Creators: name: IJMVSC
Publisher: name: Zenodo
Year: 2024

description: The survey results assess the relationship between the variables. The results indicate that customer attitudes towards services provided by private commercial banks are more positive than towards nationalized commercial banks. In addition, the survey highlights the problems and probable solutions to help manage these problems.
Additional file 6: of Correction to: SALP, a new single-stranded DNA library preparation method especially useful for the high-throughput characterization of chromatin openness states
Creators: name: Wu, Jian
name: Dai, Wei
name: Wu, Lin
name: Wang, Jinke
Publisher: name: figshare
Year: 2018
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Molecular Biology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Figure S3. Verification of the ligation efficiency of SSA adaptors. (DOCX 187 kb)
GIYOHVANDLIK BILAN BOG'LIQ HUQUQBUZARLIKLAR PROFILAKTIKASINI TASHKIL ETISH
Creators: name: Ortiqxo'jayev, Sobirjon
name: Samatov, Samatjon
Publisher: name: Zenodo
Year: 2024

description: Hozirgi kunda jamiyatimizda giyohvandlik bilan bog’liq muammolar tobora ko’payib bormoqda. Sababi shundaki, giyohvandlik va psixotrop moddalarni iste’mol qiluvchi yosh toifasi kichiklashib borib hattoki, maktab yoshiga qadar yetib bordi. Bu esa jamiyatimizning inqiroziga ham sabab bo’lishi mumkin. Jumladan, 12-16 yoshdagi maktab bolalari tomonidan sintetik tarzda tayyorlanadigan inson ongi va markaziy nerv sistemasiga ta’sir etuvchi moddalarni bir yoki ikki marta iste’mol qilish natijasida unga o’rganib qolish holatlari tobora ko’payib bormoqda. Ushbu holatlarni aniqlashda axborot texnologiyalari sohasidagi jinoyatlarga qarshi kurashish boshqarmasi, kiberxavfsizlik bosh markazi hamda uning bo’limlari tomonidan monitoring amalga oshirish orqali ularga tegishli “Telegram”, “Instagram” ijtimoiy tarmoqlaridagi guruhlar va kanallarni aniqlash, faoliyatiga chek qo’yish ishlari amalga oshirilmoqda.
Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation
Creators: name: Afya A. Baroud
name: Mihajlović-Lalić, Ljiljana E.
name: Gligorijević, Nevenka
name: Aranđelović, Sandra
name: Stanković, Dalibor
name: Siniša Radulović
name: Hecke, Kristof Van
name: Savić, Aleksandar
name: Grgurić-Šipka, Sanja
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Complexes 1–4, [Ru(L)(bpy)2]PF6, where bpy = 2,2′-bipyridine; HL = 3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72 h of drug action revealed that 2–4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 ± 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200 μM. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV–vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex–DNA interaction.
title: 01_2394
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 7: of Correction to: SALP, a new single-stranded DNA library preparation method especially useful for the high-throughput characterization of chromatin openness states
Creators: name: Wu, Jian
name: Dai, Wei
name: Wu, Lin
name: Wang, Jinke
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Table S3. Reads from a lane of Illumina Hiseq X Ten sequencing. (DOCX 15 kb)
title: Attestation pour le patient no 68
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Lettre de Jacques Leibowitch résumant l'histoire du traitement anti-vih du patient, ayant pour but, une fois signée et approuvée, de servir d'attestation de leur consentement à emprunter une voie médicamenteuse non validée (allégée).
Kinetics and mechanism of interaction of Pt(II) complex with bio-active ligands and in vitro Pt(II)-sulfur adduct formation in aqueous medium: Bio-activity and computational study
Creators: name: Avradeep Samanta
name: Ishani Mitra
name: Venkata P. Reddy, B.
name: Subhajit Mukherjee
name: Sujay Mahata
name: Linert, Wolfgang
name: Misini, Bashkim
name: Bhattacharjee, Ashish
name: Sukhamoy Dhabal
name: Goutam Kr. Ghosh
name: Moi, Sankar Ch.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Kinetics of interaction between [Pt(pic)(H2O)2](ClO4)2, 2 (where pic = 2-aminomethylpyridine) with the selected ligands DL-methionine (DL-meth) and DL-penicillamine (DL-pen) have been studied spectrophotometrically in aqueous medium separately as a function of [2] as well as [ligand], pH and temperature at constant ionic strength. The association equilibrium constants (KE) for the outer sphere complex formation have been evaluated together with the rate constants for the two subsequent steps. Activation parameters (enthalpy of activation ΔH≠ and entropy of activation ΔS≠) were calculated from the Eyring equation. An associative mechanism of substitution is proposed for both reactions on the basis of the kinetic observations, evaluated activation parameters and spectroscopic data. Structural optimizations, HOMO-LUMO energy calculation and Natural Bond Orbital (NBO) analysis of 2-4 were carried out with Density Functional Theory (DFT). Bonding mode of thiol and thio-ether is confirmed by spectroscopic analyses and NBO calculation. Cytotoxic properties of 2-4 were explored on A549 carcinoma cell lines; DNA-binding properties of the complexes were also investigated by gel electrophoresis.
Additional file 8: of Correction to: SALP, a new single-stranded DNA library preparation method especially useful for the high-throughput characterization of chromatin openness states
Creators: name: Wu, Jian
name: Dai, Wei
name: Wu, Lin
name: Wang, Jinke
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Figure S4. Comparison of fold enrichment of two types of GM12878 SALP-seq peaks. (DOCX 45 kb)
Modeling the Reaction Transport of Synaptic Acetylcholine Released at High Frequency in Weakly Electric Fish
Creators: name: Alkhammash, Elham
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: High frequency
Synaptic transmission
Weakly electric fish

description: Studying the synaptic transmission in the neuromuscular junction (NMJ) is central to the understanding of firing electrical signals at high frequencies. In this work, we present the processes involving acetylcholine and its receptors in the synaptic transmission across the cleft. A one-dimensional diffusion model is proposed to explain the behavior of the reaction -diffusion system with nonlinear reaction terms monitoring the interaction of acetylcholine with the enzyme and the receptors. A proper numerical method is applied to solve the one-dimensional diffusion equation along the symmetry axis of the cylindrically shaped cleft with Neumann boundary condition on the postsynaptic end. We assumed a periodic release of ACh in the frequency range of 200Hz to 500Hz. The kinetics of receptors (particularly the open receptors) during the release of acetylcholine to changes in selected parameters are investigated. We chose typical values for the concentration of ACh, the flux of ACh, and the surface concentration of receptors. The effects of the varying parameters, enzyme concentration, input flux, and the receptor concentration on the emission of acetylcholine in the synaptic cleft and the subsequent impact on the dynamics of the receptors are studied and discussed. As the firing rate is increased, the enzyme concentration also has to be increased to ensure that the ACh receptors (AChR) close in between two releases of ACh. Our study revealed that the enzyme reaction limits our model. The concentration of ACh reaching the receptors falls close to a threshold and the receptors do not close completely during firing at a high frequency, such as 500 Hz. Our model can be used to describe the neuronal transmission across the synaptic up to about 500Hz. This being close to the physiological limit of Eigenmannia, it suggests that the mechanism described in this thesis reflects reality.
Additional file 9: of Correction to: SALP, a new single-stranded DNA library preparation method especially useful for the high-throughput characterization of chromatin openness states
Creators: name: Wu, Jian
name: Dai, Wei
name: Wu, Lin
name: Wang, Jinke
Publisher: name: figshare
Year: 2018
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Molecular Biology
Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology

description: Figure S5. Construction of NGS library of gDNAs sheared by sonication and restriction endonuclease digestion with SALP method. (DOCX 295 kb)
Ruthenium(II) bipyridine complexes: From synthesis and crystal structures to electrochemical and cytotoxicity investigation
Creators: name: Afya A. Baroud
name: Mihajlović-Lalić, Ljiljana E.
name: Gligorijević, Nevenka
name: Aranđelović, Sandra
name: Stanković, Dalibor
name: Siniša Radulović
name: Hecke, Kristof Van
name: Savić, Aleksandar
name: Grgurić-Šipka, Sanja
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Complexes 1-4, [Ru(L)(bpy)2]PF6, where bpy = 2,2′-bipyridine; L = 3-methylpyridine-2-carboxylic acid (L1), 6-methylpyridine-2-carboxylic acid (L2), 5-bromopyridine-2-carboxylic acid (L3) and 6-bromopyridine-2-carboxylic acid (L4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72 h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 ± 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200 μM. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction.
The complex web of obesity: from genetics to precision medicine
Creators: name: M, Janaki Nair
name: Bharadwaj, Dwaipayan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Computational Biology

description: Obesity is a growing public health concern affecting both children and adults. Since it involves both genetic and environmental components, the management of obesity requires both, an understanding of the underlying genetics and changes in lifestyle. The knowledge of obesity genetics will enable the possibility of precision medicine in anti-obesity medications. Here, we explore health complications and the prevalence of obesity. We discuss disruptions in energy balance as a symptom of obesity, examining evolutionary theories, its multi-factorial origins, and heritability. Additionally, we discuss monogenic and polygenic obesity, the converging biological pathways, potential pharmacogenomics applications, and existing anti-obesity medications – specifically focussing on the leptin-melanocortin and incretin pathways. Comparisons between childhood and adult obesity genetics are made, along with insights into structural variants, epigenetic changes, and environmental influences on epigenetic signatures. With recent advancements in anti-obesity drugs, genetic studies pinpoint new targets and allow for repurposing existing drugs. This creates opportunities for genotype-informed treatment options. Also, lifestyle interventions can help in the prevention and treatment of obesity by altering the epigenetic signatures. The comparison of genetic architecture in adults and children revealed a significant overlap. However, more robust studies with diverse ethnic representation is required in childhood obesity.
Communication
Creators: name: Tangen, Jason M
name: McCarthy, Duncan
name: Linzi Wilson-Wilde
name: Corbett, Brooklyn
name: Robson, Samuel G.
name: Raymond, Jennifer
name: Osborn, Scott
name: Hayes, Robert
name: Cavallaro, Anneliese
name: Edmond, Gary
name: Eva, Kevin
name: Byard, Graham
name: Searston, Rachel A.
name: Thompson, Matthew B
Publisher: name: OSF Registries
Year: 2018

description: Preprints, publications, presentations, and other resources related to the communication of this project will be stored in this component.
Repositioning multiculturalism in Ethiopia: a case study of Netsa Hasab (Free Thought) political talk show on Walta TV
Creators: name: Nemomsa, Gizachew
name: Zerai, Abdissa
name: Jemaneh, Agaredech
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: This article examines how Ethiopian political parties promoting citizenship-based federalism position multiculturalism in their discourse, as reflected in their participation in talk shows aired on Walta TV. Building on Habermas’s theory of public sphere, it analyzed political talk shows discussing federalism among purposively selected political party leaders through the lens of Discourse Historical Approach. The analysis has indicated that the discursive practices in the talk shows were intended to center around central themes that include ensuring fair and free elections, promoting unity, creating inclusive policies, and decentralizing power. However, the party leaders employed discursive strategies of nominations, predications, and rhetorical questions to portray their nemeses as troublemakers. Alternatively, they employed a strategy of positive self-portrayal, positioning themselves as the saviors of Ethiopia from potential disintegration. This approach entailed effectively addressing any criticisms directed towards them to uphold a positive perception. As a result, the shows focused more on the personalities and political behaviors of party leaders. Therefore, the talk shows exhibit a notable dearth of substantive elements pertaining to multicultural values, with the discourses demonstrating limited engagement with the subject of multiculturalism. In so doing, the discussions raised concerns that giving priority to identity-based diversity politics might have adverse effects on the cohesion of the nation.
Situating AI on the road from data sharing to societal impact
Creators: name: Mietchen, Daniel
Publisher: name: Zenodo
Year: 2020
Subjects: subject: artificial intelligence
subject: responsible data science
subject: societal impact
subject: data sharing
subject: https://www.wikidata.org/wiki/Q11660
subject: https://www.wikidata.org/wiki/Q5227350

description: This talk is part of the AI Lunch series at the Jefferson Lab and was given remotely on 2 September 2020. Abstract By its very nature, Artificial Intelligence depends on the availability of data at scale. In this presentation - which shall be available at https://doi.org/10.5281/zenodo.3996019 when it starts - we will look at a range of factors that influence the nature and scale of data sharing, from open science to disasters, from research infrastructures to ethics, from cooperation to competition. We will then delve into how these factors affect the data life cycle and the research cycle and explore how data sharing (or the lack of it) translates into societal impact. On that journey, we will watch out for ways in which AI can and does contribute to or benefit from the sharing of data and associated resources (or not), which will then form the basis of our discussion. Further notes: https://github.com/Daniel-Mietchen/events/blob/master/JLab-AI-Lunch-Series.md
MOESM1 of Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer
Creators: name: Chen, Na
name: Wang, Jingya
name: Zhao, Yunying
name: Deng, Yu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Developmental Biology
subject: Mental Health

description: Additional file 1: Table S1. Primers used in this study. Figure S1. MIOX4 activity of the episomal expression plasmid in the wild-type strain and opi1 mutant strain with myo-inositol. All experiments were performed in triplicates and the error bar represented mean Âą standard deviation. Figure S2. myo-inositol residue in shake flask (A) and fed-batch (B) cultures when fed 60 mM (10.8 g/L) myo-inositol to the culture. All experiments were performed in triplicates and the error bar represented mean Âą standard deviation.
Encorafenib plus binimetinib for BRAF V600E-mutant metastatic NSCLC: clinical implications of the phase 2 PHAROS study
Creators: name: Ramalingam, Suresh S
name: Carlisle, Jennifer W
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Drs. Ramalingam and Carlisle discuss the incidence and pathophysiology of BRAF V600E-mutant metastatic non-small cell lung cancer and current treatment options. The podcast provides an overview of the data from the recent Pfizer-sponsored phase 2 PHAROS (NCT03915951) study, which were the basis for the recent US Food and Drug Administration approval of encorafenib plus binimetinib for BRAF V600E-mutant metastatic non-small cell lung cancer. A PDF version of this infographic is available as supplemental material.
Additional file 1: of Identification of tick-borne pathogen diversity by metagenomic analysis in Haemaphysalis longicornis from Xinyang, China
Creators: name: Zhuang, Lu
name: Du, Juan
name: Cui, Xiao-Ming
name: Li, Hao
name: Tang, Fang
name: Zhang, Pan-He
name: Hu, Jian-Gong
name: Tong, Yi-Gang
name: Feng, Zhi-Chun
name: Liu, Wei
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Multilingual abstracts in the five official working languages of the United Nations. (PDF 532 kb)
PERTURBED ANONYMIZATION: TWO LEVEL SMART PRIVACY FOR LBS MOBILE USERS
Creators: name: Gupta, Ruchika
name: Rao, Udai Pratap
name: Kumar, Manish
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 460299
subject: Artificial intelligence not elsewhere classified

description: The use of smart mobile devices like tablets, smart phones and navigational gadgets provide most promising communication and better services to mobile users. Location Based Services (LBS) have become very common in recent years. Mobile users submit their location dependent queries to the untrusted LBS server to acquire a particular service. Ideally, user’s personal information such as location data is supposed to be protected while communicating to LBS and at the same time quality of service must be maintained. Therefore, there is a need to have a balanced trade-off between privacy and quality of service. To fulfil such trade-off, this paper proposes a solution that first forms the cloaking region at mobile device, perform perturbation to handle the problem of trusted third party and the anonymizer further anonymizes the location to remove the problem of enough users required to form the cloaking region. The proposed approach protects the location privacy of the user and also maintains the quality of service by selecting appropriate service to the particular user. The proposed algorithm provides two-level location protection to the user, and thus ensures smart mobility of the LBS user.
Expression of the ARPC4 Subunit of Human Arp2/3 Severely Affects Mycobacterium tuberculosis Growth and Suppresses Immunogenic Response in Murine Macrophages
Creators: name: SACHIN SAMUCHIWAL
Publisher: name: figshare
Year: 2017
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 9.0px Helvetica} span.s1 {font: 9.5px Helvetica} Background: The search for molecules against Mycobacterium tuberculosis is urgent. The mechanisms facilitating the intramacrophage survival of Mycobacterium tuberculosis are as yet not entirely understood. However, there is evidence showing the involvement of host cell cytoskeleton in every step of establishment and persistence of mycobacterial infection. Methodology/Principal Findings: Here we show that expression of ARPC4, a subunit of the Actin related protein 2/3 (Arp2/ 3) protein complex, severely affects the pathogen’s growth. TEM studies display shedding of the mycobacterial outer-coat. Furthermore, in infected macrophages, mycobacteria expressing ARPC4 were cleared off at a much faster rate, and were unable to mount a pro-inflammatory cytokine response. The translocation of ARPC4-expressing mycobacteria to the lysosome of the infected macrophage was also impaired. Additionally, the ARPC4 subunit was shown to interact with Rv1626, an essential secretory mycobacterial protein. Real-time PCR analysis showed that upon expression of ARPC4 in mycobacteria, Rv1626 expression is downregulated as much as six-fold. Rv1626 was found to also interact with mammalian cytoskeleton protein, Arp2/3, and enhance the rate of actin polymerization. Conclusions/Significance: With crystal structures for Rv1626 and ARPC4 subunit already known, our finding lays out the effect of a novel molecule on mycobacteria, and represents a viable starting point for developing potent peptidomimetics.
3D printing process of oxidized nanocellulose and gelatin scaffold
Creators: name: Xu, Xiaodong
name: Zhou, Jiping
name: Jiang, Yani
name: Zhang, Qi
name: Shi, Hongcan
name: Liu, Dongfang
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: For tissue engineering applications tissue scaffolds need to have a porous structure to meet the needs of cell proliferation/differentiation, vascularisation and sufficient mechanical strength for the specific tissue. Here we report the results of a study of the 3D printing process for composite materials based on oxidized nanocellulose and gelatin, that was optimised through measuring rheological properties of different batches of materials after different crosslinking times, simulation of the pneumatic extrusion process and 3D scaffolds fabrication with Solidworks Flow Simulation, observation of its porous structure by SEM, measurement of pressure-pull performance, and experiments aimed at finding out the vitro cytotoxicity and cell morphology. The materials printed are highly porous scaffolds with good mechanical properties.
Adrenal suppression following epidural steroid injection; a military unique perspective. Carl Lobato MD, Charles Sibley MD, Kevin Guthmiller MD
Creators: name: Guthmiller, Kevin
Publisher: name: figshare
Year: 2017
Subjects: subject: 110301 Anaesthesiology
subject: FOS: Clinical medicine

description: Although there may be significant benefit of early aggressive ESI for treating low back and radicular pain in the military population, it is important to consider the potential adverse effect on adrenal function.
ANDROID BASED EDUCATIONAL GAME IN INDONESIAN TEYL
Creators: name: Megawati, Fika
Publisher: name: figshare
Year: 2017
Subjects: subject: 200302 English Language
subject: FOS: Languages and literature

description: This study aims to describe the effectiveness of Android based educational game to improve young learners’ ability in learning English vocabulary. The fourth graders of primary school were pointed as the subjects of this research. Pre-experimental design was applied by using (pre- and post-) test as the main instrument. Based on the statistical analysis of the data, the results show that the use of educational game from Android (App Inventor) improved the students’ English competence in learning vocabulary. The students get in-depth understanding about the topic of animal identified from the better score in post test. Furthermore, the game
greatly encourages the students in giving active participation during the classroom activities.
Adrenal suppression following epidural steroid injection - Guthmiller edits 17 Jan 2016 - submitted on figshare.docx
Creators: name: Guthmiller, Kevin
Publisher: name: figshare
Year: 2017
Subjects: subject: 110301 Anaesthesiology
subject: FOS: Clinical medicine

description: Although there may be significant benefit of early aggressive ESI for treating low back and radicular pain in the military population, it is important to consider the potential adverse effect on adrenal function.
Additional file 2 of Association between short-term neurological outcomes and extreme hyperoxia in patients with out-of-hospital cardiac arrest who underwent extracorporeal cardiopulmonary resuscitation: a retrospective observational study from a multicenter registry
Creators: name: Kashiura, Masahiro
name: Yasuda, Hideto
name: Kishihara, Yuki
name: Tominaga, Keiichiro
name: Nishihara, Masaaki
name: Hiasa, Ken-ichi
name: Tsutsui, Hiroyuki
name: Moriya, Takashi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Complete case analysis as a sensitivity analysis.
A retrospective study of non-ventilator hospital-acquired pneumonia in a Norwegian hospital: a serious medical condition in need of better and timelier microbiological diagnostics
Creators: name: Feet, Jon Anders
name: Müller, Karl Erik
name: Grewal, Harleen M. S.
name: Ulvestad, Elling
name: Heggelund, Lars
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Hospital-acquired pneumonia (HAP) is the most common hospital-acquired infection (HAI). HAP is associated with a high burden of morbidity and mortality, but the diagnosis is difficult to establish and the incidence uncertain. Patients aged ≥ 18 years hospitalised with radiologically verified non-ventilator hospital acquired pneumonia (NV-HAP) during 2018 were retrospectively identified at Drammen Hospital, a Norwegian general hospital. Infectious Diseases Society of America and the American Thoracic Society’s definition of HAP was used. In total 119 cases of NV-HAP were identified among 27,701 admissions. The incidence was 4.3 per 1000 admissions and 1.2 per 1000 patient-days. The median age was 74 years, 63% were male and median Charlson comorbidity index was 5. Coronary heart disease (42%) was the most common comorbidity. Median length of stay was 17.2 days. A blood culture was obtained in 53.8% of patients, while samples from lower airways were seldom obtained (10.9%). In-hospital mortality was 21%, accumulated 30-day mortality was 27.7% and accumulated 1-year mortality was 39.5%. Thirty-day readmission rate among survivors was 39.4%. NV-HAP was present in approximately 1 in 250 hospitalisations, most had multiple comorbidities, and 1 in 5 died in hospital. Although thorough microbiological sampling is recommended when NV-HAP is suspected, our data indicate that airway sampling is infrequent in clinical practice. Our findings underscore the need to develop microbiological diagnostic strategies to achieve targeted antimicrobial treatment that may improve patient outcomes and reduce broad-spectrum antibiotic usage.
Indoor Air DNA and RNA Microbiomes
Creators: name: Leung, Marcus
Publisher: name: figshare
Year: 2017
Subjects: subject: 60504 Microbial Ecology
subject: FOS: Biological sciences
subject: 60599 Microbiology not elsewhere classified
subject: 129999 Built Environment and Design not elsewhere classified
subject: FOS: Civil engineering

description: Abstract add here
Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water
Creators: name: Yang, Pengkun
name: Liu, Yawei
name: Chai, Ling
name: Lai, Zhenzhen
name: Fang, Xiaomin
name: Liu, Baoying
name: Zhang, Wenkai
name: Lu, Minghua
name: Xu, Yuanqing
name: Xu, Hao
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plasma Physics
subject: Computational Biology

description: A series of novel N-methyl piperidine (Nmp)-based ionic liquids with 1,2-propanediol group are synthesized and used as catalysts for both hetero-Michael addition of α,β-unsaturated amides and Knoevenagel condensation at room temperature in water; and all the examined substrates could be transformed into corresponding products in good to excellent yields. Meanwhile IL-catalyzed hetero-Michael addition of α,β-unsaturated amides in water has not been reported in the previous literatures. Additionally, the catalyst is recyclable for the two reactions. This finding provides a green catalyst for both hetero-Michael addition of α,β-unsaturated amides and Knoevenagel condensation in water.
ANDROID BASED EDUCATIONAL GAME IN INDONESIAN TEYL
Creators: name: Megawati, Fika
Publisher: name: figshare
Year: 2017
Subjects: subject: 200302 English Language
subject: FOS: Languages and literature

description: Gadgets provide advantages for life. The current world-famous software available is Android.
This software is believed to assist teachers in delivering knowledge effectively. In relation to
that idea, this study aims to describe the effectiveness of Android based educational game to
improve young learners’ ability in learning English vocabulary. The fourth graders of primary
school were pointed as the subjects of this research. Pre-experimental design was applied by
using (pre- and post-) test as the main instrument. Based on the statistical analysis of the data,
the results show that the use of educational game from Android (App Inventor) improved the
students’ English competence in learning vocabulary. The students get in-depth understanding
about the topic of animal identified from the better score in post test. Furthermore, the game
greatly encourages the students in giving active participation during the classroom activities. In
brief, using Android based educational game is one of joyful alternative teaching innovations to
support the creative young learners’ teachers.
Additional file 1 of Association between short-term neurological outcomes and extreme hyperoxia in patients with out-of-hospital cardiac arrest who underwent extracorporeal cardiopulmonary resuscitation: a retrospective observational study from a multicenter registry
Creators: name: Kashiura, Masahiro
name: Yasuda, Hideto
name: Kishihara, Yuki
name: Tominaga, Keiichiro
name: Nishihara, Masaaki
name: Hiasa, Ken-ichi
name: Tsutsui, Hiroyuki
name: Moriya, Takashi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: STROBE statement checklist.
House bulb light-induced photochemical acetalization of carbonyl compounds catalyzed by Eosin Y
Creators: name: Zhou, Quan
name: Jia, Tao
name: Li, Xiao-Xuan
name: Zhou, Lin
name: Li, Chang-Jiang
name: Feng, Yi-Si
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: We have systematically studied the reactions of acetalization and found that high reaction efficiency can be achieved using cheap and readily available organic Eosin Y as catalyst. The reaction proceeds smoothly under house bulbs and shows excellent functional group tolerance. The substrates of the reaction system are compatible with aromatic aldehydes, aliphatic aldehydes, aromatic ketones, and cyclic ketones with high yields.
Repeated doxycycline treatment among patients with neuroborreliosis: a nationwide, population-based, registry-based, matched cohort study
Creators: name: Tetens, Malte M.
name: Omland, Lars Haukali
name: Dessau, Ram B.
name: Ellermann-Eriksen, Svend
name: Andersen, Nanna S.
name: Jørgensen, Charlotte Sværke
name: Pedersen, Michael
name: Bodilsen, Jacob
name: Søgaard, Kirstine K.
name: Bangsborg, Jette
name: Nielsen, Alex Christian Yde
name: Møller, Jens Kjølseth
name: Obel, Niels
name: Lebech, Anne-Mette
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: To investigate receipt of antibiotics among patients with neuroborreliosis after initial antibiotic treatment, likely attributable to posttreatment symptoms. We performed a nationwide, matched, population-based cohort study in Denmark (2009-2021). We included all Danish patients with neuroborreliosis, i.e. a positive Borrelia burgdorferi intrathecal antibody index test and a cerebrospinal fluid leukocyte count ≥10 × 106/l, and initially treated with doxycycline. To form a comparison cohort, we randomly extracted individuals from the general population matched 1:10 to patients with neuroborreliosis on date of birth and sex. The main outcome was receipt of doxycycline, and the secondary outcome was receipt of phenoxymethylpenicillin. We calculated short-term (<1 year) and long-term (≥1 year) hazard ratios (HR) with 95% confidence intervals (95%CI). We included 463 patients with neuroborreliosis and 2,315 comparison cohort members. Compared with the comparison cohort members, patients with neuroborreliosis initially treated with doxycycline had increased receipt of additional doxycycline within 1 year (HR: 38.6, 95%CI: 17.5–85.0) and ≥1 years (HR: 3.5, 95%CI: 1.9–6.3). Compared with comparison cohort members, patients with neuroborreliosis had no increased receipt of phenoxymethylpenicillin (<1 year HR 1.0, 95%CI: 0.7–1.3; ≥1 years HR 1.2, 95%CI: 0.9–1.5). After initial antibiotic treatment, patients with neuroborreliosis have increased receipt of doxycycline particularly within one year after initial antibiotic therapy but also subsequently. The lack of increased receipt of phenoxymethylpenicillin suggests that the receipt of doxycycline was not merely due to differences in healthcare-seeking behaviour, increased risk of early Lyme borreliosis due to exposure, or differences in antibacterial usage in general.
Additional file 3 of Association between short-term neurological outcomes and extreme hyperoxia in patients with out-of-hospital cardiac arrest who underwent extracorporeal cardiopulmonary resuscitation: a retrospective observational study from a multicenter registry
Creators: name: Kashiura, Masahiro
name: Yasuda, Hideto
name: Kishihara, Yuki
name: Tominaga, Keiichiro
name: Nishihara, Masaaki
name: Hiasa, Ken-ichi
name: Tsutsui, Hiroyuki
name: Moriya, Takashi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3: The list of participating hospitals and approval numbers for the Institutional Review Board of each institution.
Genetic variation and population structure of Apis cerana in northern, central and southern mainland China, based on COXI gene sequences
Creators: name: Gong, Xueyang
name: Zhao, Wenzheng
name: Zhou, Danyin
name: Zhang, Xuan
name: Wang, Miao
name: Dong, Kun
name: He, Shaoyu
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: The eastern honey bee (Apis cerana), a Chinese native bee species, plays an important role in local ecosystems and agriculture, as it pollinates flowering plants. In this study, we assessed the genetic variation and population structure of A. cerana using the mitochondrial sequences of cytochrome c oxidase subunit I (COXI). We collected samples from 11 provinces of China and also included previously-collected data from two provinces of southern China. A total of 1,518 sequences with a length of 760 bp in 51 A. cerana populations were analyzed. We found 111 haplotypes within these sequences, of which 78 haplotypes were newly-defined in this study. The star-like median-joining network revealed that the haplotypes found in this study were monophyletic. A large difference in genetic diversity was found, including a gradual decrease from southern to northern populations. The southern populations harbored most of the genetic diversity and should therefore be protected. We also found a significant genetic structure among the studied populations, and defined five populations as key conservation populations. These results could be valuable in making management and conservation strategies, and for a better understanding of the evolutionary history of A. cerana populations in China.
Adrenal suppression following epidural steroid injection; a military unique perspective
Creators: name: Guthmiller, Kevin
Publisher: name: figshare
Year: 2017
Subjects: subject: 110301 Anaesthesiology
subject: FOS: Clinical medicine

description: Although there may be significant benefit of early aggressive ESI for treating low back and radicular pain in the military population, it is important to consider the potential adverse effect on adrenal function.