cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Concert v. Hr. Capellmeister Spohr
Creators: name: Allgemeine Musik-Gesellschaft Zürich
Publisher: name: [s.n.]
Year: 1816

description: Abrechnung des Benefiz-Conzerts (Verzeichnis der Einnahmen & Ausgaben über das dem Herrn Capellmeister Spohr Montags den 8ten Aprill 1816 bewilligte Benefiz-Conzerte) mit Empfangsbestätigung und Unterschrift von Louis Spohr
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
Creators: name: Chen, Vincent B.
name: Richardson, David C.
name: Richardson, Jane S.
name: Arendall III, W. Bryan
name: Leaver-Fay, Andrew
name: Block, Jeremy N.
name: Davis, Ian W.
name: Murray, Laura W.
name: Kapral, Gary J.
name: Wang, Xueyi
name: Snoeyink, Jack
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: MolProbity is a general-purpose web server offering quality validation for 3D structures of proteins, nucleic acids and complexes. It provides detailed all-atom contact analysis of any steric problems within the molecules as well as updated dihedral-angle diagnostics, and it can calculate and display the H-bond and van der Waals contacts in the interfaces between components. An integral step in the process is the addition and full optimization of all hydrogen atoms, both polar and nonpolar. New analysis functions have been added for RNA, for interfaces, and for NMR ensembles. Additionally, both the web site and major component programs have been rewritten to improve speed, convenience, clarity and integration with other resources. MolProbity results are reported in multiple forms: as overall numeric scores, as lists or charts of local problems, as downloadable PDB and graphics files, and most notably as informative, manipulable 3D kinemage graphics shown online in the KiNG viewer. This service is available free to all users at http://molprobity.biochem.duke.edu.
Comparative analysis of the $Λ_b \rightarrow Λ\ell^+ \ell^-$ decay in the SM, SUSY and RS model with custodial protection
Creators: name: Azizi, K.
name: Olgun, A. T.
name: Tavukoglu, Z.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We comparatively analyze the rare $Λ_b\rightarrow Λ\ell^+ \ell^-$ channel in standard model, supersymmetry and Randall-Sundrum model with custodial protection (RS$_c$). Using the parametrization of the matrix elements entering the low energy effective Hamiltonian in terms of form factors, we calculate the corresponding differential decay width and lepton forward-backward asymmetry in these models. We compare the results obtained with the most recent data from LHCb as well as lattice QCD results on the considered quantities. It is obtained that the standard model, with the form factors calculated in light-cone QCD sum rules, can not reproduce some experimental data on the physical quantities under consideration but the supersymmetry can do it. The RS$_c$ model predictions are roughly the same as the standard model and there are no considerable differences between the predictions of these two models. In the case of differential decay rate, the data in the range $4 $ GeV$^2/$c$^4\leq$ $q^2 \leq 6$ GeV$^2/$c$^4$ can not be described by any of the considered models.
description: 28 Pages, 12 Figures and 3 Tables
La disciplina del trasporto pubblico locale: recenti sviluppi e prospettive
Creators: name: Claroni, Alessio
Publisher: name: Universit� degli Studi di Trento
Year: 2011

description: Il volume, che fa seguito all'incontro seminariale dal titolo ?La disciplina del trasporto pubblico locale: recenti sviluppi e prospettive? svoltosi presso la Facolt� di Giurisprudenza dell?Universit� degli Studi di Trento in data 1� aprile 2011, si manifesta quale esposizione dei relativi risultati scientifici raggiunti, sotto forma di raccolta dei contributi in quella occasione presentati e, quindi, aggiornati e rivisitati per la presente pubblicazione. In tale contesto, il volume si propone di offrire, in una prospettiva teorico-pratica, una analisi della disciplina giuridica sottesa alla riforma del trasporto pubblico locale in Italia, che si estenda alla indagine dei pi� recenti sviluppi in tal senso previsti dal Legislatore, nel contempo delineando interessanti soluzioni interpretative al problema della abrogazione dell?art. 23-bis del d.l. 25 giugno 2008, n. 112.
Livre de Magasin
Creators: name: Bourcard Fils et Cie
Publisher: name: [s.n.]
Year: 1813

description: Darin: Register
description: Verzeichnung=Description=Inventaire 14.03.2017 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Additional file 1 of Second primary colorectal cancer in adults: a SEER analysis of incidence and outcomes
Creators: name: Lun, Weijian
name: Luo, Canhua
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. The initial primary tumor sites of spCRC patients.
(4267) Alexander Rodger
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary information Table S1 and Table S2 from Bionics and green technology in maritime shipping: an assessment of the effect of Salvinia air-layer hull coatings for drag and fuel reduction.
Creators: name: J. Busch
name: W. Barthlott
name: M. Brede
name: W. Terlau
name: M. Mail
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 90799 Environmental Engineering not elsewhere classified
subject: FOS: Environmental engineering
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: To save energy and reduce environmental impacts, new technologies towards a development of a sustainable ‘greener’ economy are needed. The main opportunity to improve sustainability by reducing emissions is within the transport sector. More than 90% of all goods worldwide are transported by ships. Particularly maritime ships using heavy fuel oil and marine gas oil play a major role. The total fuel consumption of shipping in 2016 was about 250 m t (domestic ca. 50 m t, international shipping ca. 200 m t). The vast portion of the energy consumption of a ship is the need to overcome the drag between ship hull and water—depending on the shape of the vessel and its size up to 90% of total fuel consumption. This means reducing drag helps to save fuel and reduces carbon emissions as well as pollution considerably. Different techniques for drag reduction are known, e.g. the micro-bubble technique or the bulbous bow. We investigated a novel bioinspired technique since 2002: the application of biomimetic surfaces with long-term stable air layers on ship hulls, serving as a slip agent. This technology is based on the Salvinia Effect, allowing a permanent stabilization of air layers under water. In this case study, we analysed the possible savings, which also could be combined with modified micro-bubble technologies. We calculated, based on a selection of five ship types, representing 75% of the world fleet, that air-layer hull coatings could lead to estimated savings of 32.5 million tons of fuel (meaning 13.0% of the worldwide shipping fuel consumption), equal to 18.5 billion US$ and 130.0 million tons of CO2e per year. The positive impacts on global temperature and other greenhouse gases are calculated and could be a contributing factor in accomplishing the UN Sustainable Development Goals and the Paris Agreement to the UN Framework Convention on Climate Change. The study is a contribution to enhance our patchy knowledge concerning the potential economic and ecological benefit of bionics and biomimetic technologies.This article is part of the theme issue ‘Bioinspired materials and surfaces for green science and technology’.
Additional file 1 of Age-related differences in eating location, food source location, and timing of snack intake among U.S. children 1–19 years
Creators: name: Tripicchio, Gina L.
name: Croce, Christina M.
name: Coffman, Donna L.
name: Pettinato, Cameron
name: Fisher, Jennifer O.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs
Creators: name: Griffith, Jack D.
name: Thornton, Charles A.
name: Sobczak, Krzysztof
name: Stenberg, Myrna G.
name: Yuan, Yuan
name: Compton, Sarah A.
name: Swanson, Maurice S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The MBNL and CELF proteins act antagonistically to control the alternative splicing of specific exons during mammalian postnatal development. This process is dysregulated in myotonic dystrophy because MBNL proteins are sequestered by (CUG)n and (CCUG)n RNAs expressed from mutant DMPK and ZNF9 genes, respectively. While these observations predict that MBNL proteins have a higher affinity for these pathogenic RNAs versus their normal splicing targets, we demonstrate that MBNL1 possesses comparably high affinities for (CUG)n and (CAG)n RNAs as well as a splicing target, Tnnt3. Mapping of a MBNL1-binding site upstream of the Tnnt3 fetal exon indicates that a preferred binding site for this protein is a GC-rich RNA hairpin containing a pyrimidine mismatch. To investigate how pathogenic RNAs sequester MBNL1 in DM1 cells, we used a combination of chemical/enzymatic structure probing and electron microscopy to determine that MBNL1 forms a ring-like structure which binds to the dsCUG helix. While the MBNL1 N-terminal region is required for RNA binding, the C-terminal region mediates homotypic interactions which may stabilize intra- and/or inter-ring interactions. Our results provide a mechanistic basis for dsCUG-induced MBNL1 sequestration and highlight a striking similarity in the binding sites for MBNL proteins on splicing precursor and pathogenic RNAs.
Supplementary material, table S1 from Bionics and green technology in maritime shipping: an assessment of the effect of Salvinia air-layer hull coatings for drag and fuel reduction
Creators: name: J. Busch
name: W. Barthlott
name: M. Brede
name: W. Terlau
name: M. Mail
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 90799 Environmental Engineering not elsewhere classified
subject: FOS: Environmental engineering
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: To save energy and reduce environmental impacts, new technologies towards a development of a sustainable ‘greener’ economy are needed. The main opportunity to improve sustainability by reducing emissions is within the transport sector. More than 90% of all goods worldwide are transported by ships. Particularly maritime ships using heavy fuel oil and marine gas oil play a major role. The total fuel consumption of shipping in 2016 was about 250 m t (domestic ca. 50 m t, international shipping ca. 200 m t). The vast portion of the energy consumption of a ship is the need to overcome the drag between ship hull and water—depending on the shape of the vessel and its size up to 90% of total fuel consumption. This means reducing drag helps to save fuel and reduces carbon emissions as well as pollution considerably. Different techniques for drag reduction are known, e.g. the micro-bubble technique or the bulbous bow. We investigated a novel bioinspired technique since 2002: the application of biomimetic surfaces with long-term stable air layers on ship hulls, serving as a slip agent. This technology is based on the Salvinia Effect, allowing a permanent stabilization of air layers under water. In this case study, we analysed the possible savings, which also could be combined with modified micro-bubble technologies. We calculated, based on a selection of five ship types, representing 75% of the world fleet, that air-layer hull coatings could lead to estimated savings of 32.5 million tons of fuel (meaning 13.0% of the worldwide shipping fuel consumption), equal to 18.5 billion US$ and 130.0 million tons of CO2e per year. The positive impacts on global temperature and other greenhouse gases are calculated and could be a contributing factor in accomplishing the UN Sustainable Development Goals and the Paris Agreement to the UN Framework Convention on Climate Change. The study is a contribution to enhance our patchy knowledge concerning the potential economic and ecological benefit of bionics and biomimetic technologies.This article is part of the theme issue ‘Bioinspired materials and surfaces for green science and technology’.
Simulating coronal condensation dynamics in 3D
Creators: name: Moschou, S. P.
name: Keppens, R.
name: Xia, C.
name: Fang, X.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present numerical simulations in 3D settings where coronal rain phenomena take place in a magnetic configuration of a quadrupolar arcade system. Our simulation is a magnetohydrodynamic simulation including anisotropic thermal conduction, optically thin radiative losses, and parametrised heating as main thermodynamical features to construct a realistic arcade configuration from chromospheric to coronal heights. The plasma evaporation from chromospheric and transition region heights eventually causes localised runaway condensation events and we witness the formation of plasma blobs due to thermal instability, that evolve dynamically in the heated arcade part and move gradually downwards due to interchange type dynamics. Unlike earlier 2.5D simulations, in this case there is no large scale prominence formation observed, but a continuous coronal rain develops which shows clear indications of Rayleigh-Taylor or interchange instability, that causes the denser plasma located above the transition region to fall down, as the system moves towards a more stable state. Linear stability analysis is used in the non-linear regime for gaining insight and giving a prediction of the system's evolution. After the plasma blobs descend through interchange, they follow the magnetic field topology more closely in the lower coronal regions, where they are guided by the magnetic dips.
description: 47 pages, 59 figures
Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
Creators: name: Zhou, Rui Zhe
name: Ramsden, Dale A.
name: Povirk, Lawrence F.
name: Lees-Miller, Susan P.
name: Valerie, Kristoffer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Previous work suggested that phosphorylation of DNA-PKcs at several serine/threonine (S/T) residues at positions 2609–2647 promotes DNA-PK-dependent end joining. In an attempt to clarify the role of such phosphorylation, end joining was examined in extracts of DNA-PKcs-deficient M059J cells. Joining of ends requiring gap filling prior to ligation was completely dependent on complementation of these extracts with exogenous DNA-PKcs. DNA-PKcs with either S/T → A or S/T → D substitutions at all six sites in the 2609–2647 cluster also supported end joining, but with markedly lower efficiency than wild-type protein. The residual end joining was greater with the S/T → D-substituted than with the S/T → A-substituted protein. A specific inhibitor of the kinase activity of DNA-PK, KU57788, completely blocked end joining promoted by wild type as well as both mutant forms of DNA-PK, while inhibition of ATM kinase did not. The fidelity of end joining was not affected by the mutant DNA-PKcs alleles or the inhibitors. Overall, the results support a role for autophosphorylation of the 2609–2647 cluster in promoting end joining and controlling the accessibility of DNA ends, but suggest that DNA-PK-mediated phosphorylation at other sites, on either DNA-PKcs or other proteins, is at least as important as the 2609–2647 cluster in regulating end joining.
Retinoic acid modulates chromatin to potentiate tumor necrosis factor alpha signaling on the DIF2 promoter
Creators: name: Baldwin, Albert S.
name: Padovani, Alessandra
name: Pettersson, Filippa
name: Dupéré-richer, Daphne
name: Summers-deluca, Leslie
name: Miller Jr., Wilson H.
name: Witcher, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Transcriptional activation by nuclear hormone receptors is well characterized, but their cooperation with other signaling pathways to activate transcription remains poorly understood. Tumor necrosis factor alpha (TNFα) and all-trans retinoic acid (RA) induce monocytic differentiation of acute promyelocytic leukemia (APL) cells in a synergistic manner. We used the promoter of DIF2, a gene involved in monocytic differentiation, to model the mechanism underlying the cooperative induction of target genes by RA and TNFα. We show a functional RA response element in the DIF2 promoter, which is constitutively bound by PML/RARα in APL cells. RA stimulates release of corepressors and recruitment of chromatin modifying proteins and additional transcription factors to the promoter, but these changes cause only a modest induction of DIF2 mRNA. Co-stimulation with RA plus TNFα facilitates binding of NF-κB to the promoter, which is crucial for full induction of transcription. Furthermore, RA plus TNFα greatly enhanced the level of RNA Pol II phosphorylation on the DIF2 promoter, via synergistic recruitment of TFIIH. We propose that RA mediates remodeling of chromatin to facilitate binding of transcription factors, which cooperate to enhance Pol II phosphorylation, providing a mechanism whereby nuclear receptors interact with other signaling pathways on the level of transcription.
On the origin of the Extreme-Ultraviolet late phase of solar flares
Creators: name: Liu, Kai
name: Zhang, Jie
name: Wang, Yuming
name: Cheng, Xin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Solar flares typically have an impulsive phase that followed by a gradual phase as best seen in soft X-ray emissions. A recent discovery based on the EUV Variability Experiment (EVE) observations onboard the Solar Dynamics Observatory (SDO) reveals that some flares exhibit a second large peak separated from the first main phase peak by tens of minutes to hours, which is coined as the flare's EUV late phase. In this paper, we address the origin of the EUV late phase by analyzing in detail two late phase flares, an M2.9 flare on 2010 October 16 and an M1.4 flare on 2011 February 18, using multi-passband imaging observations from the Atmospheric Imaing Assembly (AIA) onboard SDO. We find that: (1) the late phase emission originates from a different magnetic loop system, which is much larger and higher than the main phase loop system. (2) The two loop systems have different thermal evolution. While the late phase loop arcade reaches its peak brightness progressively at a later time spanning for more than one hour from high to low temperatures, the main phase loop arcade reaches its peak brightness at almost the same time (within several minutes) in all temperatures. (3) Nevertheless, the two loop systems seem to be connected magnetically, forming an asymmetric magnetic quadruple configuration. (4) Further, the footpoint brightenings in UV wavelengths show a systematic delay of about one minute from the main flare region to the remote footpoint of the late phase arcade system. We argue that the EUV late phase is the result of a long-lasting cooling process in the larger magnetic arcade system.
description: 12 figures
End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
Creators: name: Davis, Bryan J.
name: Havener, Jody M.
name: Ramsden, Dale A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: DNA polymerase μ is a member of the mammalian pol X family and reduces deletion during chromosome break repair by nonhomologous end joining (NHEJ). This biological role is linked to pol μ's ability to promote NHEJ of ends with noncomplementary 3′ overhangs, but questions remain regarding how it performs this role. We show here that synthesis by pol μ in this context is often rapid and, despite the absence of primer/template base-pairing, instructed by template. However, pol μ is both much less active and more prone to possible template independence in some contexts, including ends with overhangs longer than two nucleotides. Reduced activity on longer overhangs implies pol μ is less able to synthesize across longer gaps, arguing pol μ must bridge both sides of gaps between noncomplementary ends to be effective in NHEJ. Consistent with this argument, a pol μ mutant defective specifically on gapped substrates is also less active during NHEJ of noncomplementary ends both in vitro and in cells. Taken together, pol μ activity during NHEJ of noncomplementary ends can thus be primarily linked to pol μ's ability to work together with core NHEJ factors to bridge DNA ends and perform a template-dependent gap fill-in reaction.
Identification and recovery of minor HIV-1 variants using the heteroduplex tracking assay and biotinylated probes
Creators: name: Schnell, Gretja
name: Ince, William L.
name: Swanstrom, Ronald
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We describe a method to identify and recover minor human immunodeficiency virus type 1 (HIV-1) sequence variants from a complex population. The original heteroduplex tracking assay (HTA) was modified by incorporating a biotin tag into the probe to allow for direct sequence determination of the query strand. We used this approach to recover sequences from minor HIV-1 variants in the V3 region of the env gene, and to identify minor drug-resistant variants in pro. The biotin-HTA targeting of the V3 region of env allowed us to detect minor V3 variants, of which 45% were classified as CXCR4-using viruses. In addition, the biotin-protease HTA was able to detect mixtures of wild-type sequence and drug-resistance mutations in four subjects that were not detected by bulk sequence analysis. The biotin-HTA is a robust assay that first separates genetic variants then allows direct sequence analysis of major and minor variants.
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
Creators: name: Trejo, Joann
name: Li, Zi Bo
name: Fisher, Michael
name: Juliano, Rudy L.
name: Chen, Xiaoyuan
name: Dixit, Vidula
name: Alam, Rowshon
name: Kang, Hyunmin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We describe the synthesis and characterization of a 5′ conjugate between a 2′-O-Me phosphorothioate antisense oligonucleotide and a bivalent RGD (arginine–glycine–aspartic acid) peptide that is a high-affinity ligand for the αvβ3 integrin. We used αvβ3-positive melanoma cells transfected with a reporter comprised of the firefly luciferase gene interrupted by an abnormally spliced intron. Intranuclear delivery of a specific antisense oligonucleotide (termed 623) corrects splicing and allows luciferase expression in these cells. The RGD–623 conjugate or a cationic lipid-623 complex produced significant increases in luciferase expression, while ‘free’ 623 did not. However, the kinetics of luciferase expression was distinct; the RGD–623 conjugate produced a gradual increase followed by a gradual decline, while the cationic lipid-623 complex caused a rapid increase followed by a monotonic decline. The subcellular distribution of the oligonucleotide delivered using cationic lipids included both cytoplasmic vesicles and the nucleus, while the RGD–623 conjugate was primarily found in cytoplasmic vesicles that partially co-localized with a marker for caveolae. Both the cellular uptake and the biological effect of the RGD–623 conjugate were blocked by excess RGD peptide. These observations suggest that the bivalent RGD peptide–oligonucleotide conjugate enters cells via a process of receptor-mediated endocytosis mediated by the αvβ3 integrin.
title: Investigation and implementation of image super-resolution using CNNs applied to OCR
Creators: name: Werner, Florian
Publisher: name: Hochschule Hannover
Year: 2022
Subjects: subject: 004 Informatik

description: Recent developments in the field of deep learning have shown promising advances for a wide range of historically difficult computer vision problems. Using advanced deep learning techniques, researchers manage to perform high-quality single-image super-resolution, i.e., increasing the resolution of a given image without major losses in image quality, usually encountered when using traditional approaches such as standard interpolation. This thesis examines the process of deep learning super-resolution using convolutional neural networks and investigates whether the same deep learning models can be used to increase OCR results for low-quality text images.
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
Creators: name: Alam, Md Rowshon
name: Kang, Hyumin
name: Juliano, Rudy
name: Dixit, Vidula
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules. In this Survey and Summary, we review recent reports on delivery strategies, including conjugates of oligonucleotides with various ligands, as well as use of nanocarrier approaches. These are discussed in the context of intracellular trafficking pathways and issues regarding in vivo biodistribution of molecules and nanoparticles. Molecular-sized chemical conjugates and supramolecular nanocarriers each display advantages and disadvantages in terms of effective and nontoxic delivery. Thus, choice of an optimal delivery modality will likely depend on the therapeutic context.
The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3 mt
Creators: name: Spremulli, Linda L.
name: Haque, Md Emdadul
name: Grasso, Domenick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Mammalian mitochondrial initiation factor 3 (IF3mt) has a central region with homology to bacterial IF3. This homology region is preceded by an N-terminal extension and followed by a C-terminal extension. The role of these extensions on the binding of IF3mt to mitochondrial small ribosomal subunits (28S) was studied using derivatives in which the extensions had been deleted. The Kd for the binding of IF3mt to 28S subunits is ∼30 nM. Removal of either the N- or C-terminal extension has almost no effect on this value. IF3mt has very weak interactions with the large subunit of the mitochondrial ribosome (39S) (Kd = 1.5 μM). However, deletion of the extensions results in derivatives with significant affinity for 39S subunits (Kd = 0.12−0.25 μM). IF3mt does not bind 55S monosomes, while the deletion derivative binds slightly to these particles. IF3mt is very effective in dissociating 55S ribosomes. Removal of the N-terminal extension has little effect on this activity. However, removal of the C-terminal extension leads to a complex dissociation pattern due to the high affinity of this derivative for 39S subunits. These data suggest that the extensions have evolved to ensure the proper dissociation of IF3mt from the 28S subunits upon 39S subunit joining.
A relativistic acoustic metric for planar black holes
Creators: name: Hossenfelder, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We demonstrate here that the metric of a planar black hole in asymptotic Anti-de Sitter space can, on a slice of dimension 3+1, be reproduced as a relativistic acoustic metric. This completes an earlier calculation in which the non-relativistic limit was used, and also serves to obtain a concrete form of the Lagrangian.
description: 11 pages, no figures, replaced with published version
Additional file 2 of Age-related differences in eating location, food source location, and timing of snack intake among U.S. children 1–19 years
Creators: name: Tripicchio, Gina L.
name: Croce, Christina M.
name: Coffman, Donna L.
name: Pettinato, Cameron
name: Fisher, Jennifer O.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 2
Rings and Radial Waves in the Disk of the Milky Way
Creators: name: Xu, Yan
name: Newberg, Heidi Jo
name: Carlin, Jeffrey L.
name: Liu, Chao
name: Deng, Licai
name: Li, Jing
name: Schönrich, Ralph
name: Yanny, Brian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We show that in the anticenter region, between Galactic longitudes of $110^\circ
description: 19figures, 2tables, ApJ accepted
MICRORNA INVOLVEMENT IN COLON CANCER PROGRESSION
Creators: name: SOKOLOVA, VIKTORIJA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Loss of response to TGF-? occurs in many cancers and disruption of its regulatory circuitry appears as a central event in the genesis of colorectal cancer (CRC) malignancy. Lack of an inhibitory response to TGF-? is common to most colon cancer cell lines. Recently, abrogation of the TGF-? growth inhibitory response mediated by different miRNAs has been reported. By searching for miRNAs in regions showing copy number changes and concordant gene expression in 36 sporadic CRCs compared to their normal counterpart, we identified the miR-17-92 cluster localized on the 13q31 locus, gained and highly expressed at early stages of CRC. We selected the TGF-? sensitive FET colon carcinoma and investigated the relationship between enhanced expression of miR-20a and TGF-? mediated growth inhibition. We found that miR-20a affects p21 levels and has a negative and significant effect on the cytostatic response mediated by TGF-?. We confirmed that p21 down-modulation is addressed by direct binding of its 3?-UTR by miR-20a. Moreover, we observed also that miR-20a is able to block the transactivation of the 2.3-kb CDKN1A promoter upon TGF-? stimulation, but not the activation of the Smad3/4-reponsive reporter. We also found that two of the c-MYC repressor genes, E2F5 and KLF11, are directly targeted by miR-20a, thus resulting in abrogation of the TGF-? mediated repression of c-MYC. Our experiments suggest for miR-20a an interference with the TGF-? homeostasis in colon cancer addressing the up-regulation of p21 expression, through mechanisms involving more effectors of the TGF-? cascade.
WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand
Creators: name: Tudek, Barbara
name: Bukowy, Zuzanna
name: Stevnsner, Tinna
name: Ramsden, Dale A.
name: Harrigan, Jeanine A.
name: Bohr, Vilhelm A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Werner syndrome (WS) is a premature aging disorder caused by mutations in the WS gene (WRN). Although WRN has been suggested to play an important role in DNA metabolic pathways, such as recombination, replication and repair, its precise role still remains to be determined. WRN possesses ATPase, helicase and exonuclease activities. Previous studies have shown that the WRN exonuclease is inhibited in vitro by certain lesions induced by oxidative stress and positioned in the digested strand of the substrate. The presence of the 70/86 Ku heterodimer (Ku), participating in the repair of double-strand breaks (DSBs), alleviates WRN exonuclease blockage imposed by the oxidatively induced DNA lesions. The current study demonstrates that WRN exonuclease is inhibited by several additional oxidized bases, and that Ku stimulates the WRN exonuclease to bypass these lesions. Specific lesions present in the non-digested strand were shown also to inhibit the progression of the WRN exonuclease; however, Ku was not able to stimulate WRN exonuclease to bypass these lesions. Thus, this study considerably broadens the spectrum of lesions which block WRN exonuclease progression, shows a blocking effect of lesions in the non-digested strand, and supports a function for WRN and Ku in a DNA damage processing pathway.
Inflation in a viscous fluid model
Creators: name: Bamba, Kazuharu
name: Odintsov, Sergei D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We explore a fluid description of the inflationary universe. In particular, we investigate a fluid model in which the equation of state (EoS) for a fluid includes bulk viscosity. We find that the three observables of inflationary cosmology: the spectral index of the curvature perturbations, the tensor-to-scalar ratio of the density perturbations, and the running of the spectral index, can be consistent with the recent Planck results. We also reconstruct the explicit EoS for a fluid from the spectral index of the curvature perturbations compatible with the Planck analysis. In the reconstructed models of a fluid, the tensor-to-scalar ratio of the density perturbations can satisfy the constraints obtained from the Planck satellite. The running of the spectral index can explain the Planck data. In addition, it is demonstrated that in the reconstructed models of a fluid, the graceful exit from inflation can be realized. Moreover, we show that the singular inflation can occur in a fluid model. Furthermore, we show that a fluid description of inflation can be equivalent to the description of inflation in terms of scalar field theories.
description: 14 pages, no figure, version accepted for publication in the European Physical Journal C
A capstone project report submitted to the school of graduate studies of Addis Ababa University, college of Health Science, Department of Health Service Management and Policy in partial fulfillment of the requirements for the degree of Masters of science in Hospital and Health Care Administration
Creators: name: Dereje Bokan
Publisher: name: Zenodo
Year: 2019

description: Background: Medical records management is one of the components of health information

system that documents information related to a patient generated during patient-to-health care

provider encounters at a health care facility. A well-managed medical records system is critical

to improve the provision of quality health care services to ensure safe medical practice, efficient

and effective services and improve the patient’s experience and satisfaction with their medical

encounter.

Objective:-To improve outpatient medical record completion from 37% to 90% in

Enchini Hospital at the end of June 2019GC.

Methods:A pre- post intervention design was used in this project to examine the completion rate

of outpatient medical record. The pre-intervention assessment was conducted in the outpatient

department of Enchini hospital. Base line data were collected between January and March

2019. The baseline data showed the completeness of outpatient medical records was low. Only

37% of the 50 audited patient folders were completed. A questionnaire was developed to assess

knowledge gabs of all workers who were working at outpatient department such as nurses,

general practitioners and medical record workers, whether supportive supervision was

conducted by senior management team and availability of printing formats and materials. The

root cause analysis was conducted to identify the root cause of the problem. Based on the

verification, lack of awareness about outpatient medical record completeness was identified as a

real root cause and a two day’s staff training on medical record completeness was conducted.
title: A Comparison of Continuous-Wave and Pulsed Free Space 2-Port Photonic Vector Network Analyzers for Terahertz Characterization
Creators: name: Faridi, Fahd Rushd
name: Fernandez Olvera, Anuar De Jesus
name: Mukherjee, Amlan K.
name: Preu, Sascha
Publisher: name: IEEE
Year: 2022

description: Photonic Vector Network Analyzers (PVNA) provide a viable solution to the rising demand for efficient, accurate, and affordable characterization instruments for benchmarking terahertz devices and components. This paper compares continuous-wave and pulsed versions of the free space 2-port PVNA and their aptitudes for THz characterization using a distributed Bragg reflector as an application example.
Additional file 3 of Age-related differences in eating location, food source location, and timing of snack intake among U.S. children 1–19 years
Creators: name: Tripicchio, Gina L.
name: Croce, Christina M.
name: Coffman, Donna L.
name: Pettinato, Cameron
name: Fisher, Jennifer O.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 3
Supplementary Material - Prevalence of admission hyponatremia in diabetic patients treated with and without an SGLT2-inhibitor - a cross-sectional study
Creators: name: Monnerat, Sophie
name: Atila, Cihan
name: Refardt, Julie
name: Christ-Crain, Mirjam
Publisher: name: Zenodo
Year: 2023

description: Supplementary Material - Prevalence of admission hyponatremia in diabetic patients treated with and without an SGLT2-inhibitor - a cross-sectional study
Supplemental Tables and Figures from Phagocyte chase behaviours: discrimination between Gram-negative and Gram-positive bacteria by amoebae.
Creators: name: Rashidi, Ghazal
name: Ostrowski, Elizabeth A.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Detailed methods, Tables S1 and S2, Figures S1 and S2
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
Creators: name: Brent, Michael
name: Eis, Peggy S.
name: Graubert, Timothy A.
name: Cahan, Patrick
name: Godfrey, Laura E.
name: Richmond, Todd A.
name: Selzer, Rebecca R.
name: Mcleod, Howard L.
name: Ley, Timothy J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Copy number variants (CNVs) are currently defined as genomic sequences that are polymorphic in copy number and range in length from 1000 to several million base pairs. Among current array-based CNV detection platforms, long-oligonucleotide arrays promise the highest resolution. However, the performance of currently available analytical tools suffers when applied to these data because of the lower signal:noise ratio inherent in oligonucleotide-based hybridization assays. We have developed wuHMM, an algorithm for mapping CNVs from array comparative genomic hybridization (aCGH) platforms comprised of 385 000 to more than 3 million probes. wuHMM is unique in that it can utilize sequence divergence information to reduce the false positive rate (FPR). We apply wuHMM to 385K-aCGH, 2.1M-aCGH and 3.1M-aCGH experiments comparing the 129X1/SvJ and C57BL/6J inbred mouse genomes. We assess wuHMM's performance on the 385K platform by comparison to the higher resolution platforms and we independently validate 10 CNVs. The method requires no training data and is robust with respect to changes in algorithm parameters. At a FPR of <10%, the algorithm can detect CNVs with five probes on the 385K platform and three on the 2.1M and 3.1M platforms, resulting in effective resolutions of 24 kb, 2–5 kb and 1 kb, respectively.
Signs of universality in the structure of culture
Creators: name: Băbeanu, Alexandru-Ionuţ
name: Talman, Leandros
name: Garlaschelli, Diego
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Computers and Society (cs.CY)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Understanding the dynamics of opinions, preferences and of culture as whole requires more use of empirical data than has been done so far. It is clear that an important role in driving this dynamics is played by social influence, which is the essential ingredient of many quantitative models. Such models require that all traits are fixed when specifying the "initial cultural state". Typically, this initial state is randomly generated, from a uniform distribution over the set of possible combinations of traits. However, recent work has shown that the outcome of social influence dynamics strongly depends on the nature of the initial state. If the latter is sampled from empirical data instead of being generated in a uniformly random way, a higher level of cultural diversity is found after long-term dynamics, for the same level of propensity towards collective behavior in the short-term. Moreover, if the initial state is randomized by shuffling the empirical traits among people, the level of long-term cultural diversity is in-between those obtained for the empirical and uniformly random counterparts. The current study repeats the analysis for multiple empirical data sets, showing that the results are remarkably similar, although the matrix of correlations between cultural variables clearly differs across data sets. This points towards robust structural properties inherent in empirical cultural states, possibly due to universal laws governing the dynamics of culture in the real world. The results also suggest that this dynamics might be characterized by criticality and involve mechanisms beyond social influence.
description: 16 pages, 7 figures; the same results as in version 3, but a shorter Introduction, Discussion and Conclusion
THE COUNCIL OF STATE AS A POLITICAL ACTOR. ORIGINS AND STRATEGIC IMPLICATIONS OF THE CONTROL ON ADMINISTRATIVE ACTS
Creators: name: REBESSI, ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: This work analyzes the Councils of State and more in general the administrative courts as political actors. Councils of State are peculiar unelected bodies that present a double, ?amphibious? nature. As advisory boards of the government on legislation, they belong to the executive. However, as highest courts responsible for the judicial review of administrative acts, they are also part of the judiciary. Adopting a strategic approach to the analysis of the relations between the legislature and the judiciary, the research investigates the interaction between government and the Council of State in the Italian case. The first question I intend to answer is if the interaction between the two institutions in the process of implementation of primary laws produces different outcomes, according to the political circumstances. More precisely, I analyze the extent to which the level of government ideological heterogeneity and the size of alternation affect the probability to activate the Council of State as Advisor. Second, I try to answer if the political factors that determine the activation of the Council of State in Italy also play a role in influencing the institutional characteristics of courts that review administrative acts in other countries. Following the game theoretical framework adopted for the Italian case, I examine the characteristics of courts that review administrative acts in fifteen European countries, showing the correlation between courts? institutional features and the prevailing political conditions (taking into consideration the post-Second World War period through the end of the 1990s). The data seem to suggest that the causal mechanisms that explain the activation of the Italian Council of State as Advisor can be behind the different role played by the administrative judiciary in the executive politics in other European Countries.
Analysis of re-replication from deregulated origin licensing by DNA fiber spreading
Creators: name: Hall, Jonathan R.
name: Dorn, Elizabeth S.
name: Chastain II, Paul D.
name: Cook, Jeanette Gowen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: A major challenge each human cell-division cycle is to ensure that DNA replication origins do not initiate more than once, a phenomenon known as re-replication. Acute deregulation of replication control ultimately causes extensive DNA damage, cell-cycle checkpoint activation and cell death whereas moderate deregulation promotes genome instability and tumorigenesis. In the absence of detectable increases in cellular DNA content however, it has been difficult to directly demonstrate re-replication or to determine if the ability to re-replicate is restricted to a particular cell-cycle phase. Using an adaptation of DNA fiber spreading we report the direct detection of re-replication on single DNA molecules from human chromosomes. Using this method we demonstrate substantial re-replication within 1 h of S phase entry in cells overproducing the replication factor, Cdt1. Moreover, a comparison of the HeLa cancer cell line to untransformed fibroblasts suggests that HeLa cells produce replication signals consistent with low-level re-replication in otherwise unperturbed cell cycles. Re-replication after depletion of the Cdt1 inhibitor, geminin, in an untransformed fibroblast cell line is undetectable by standard assays but readily quantifiable by DNA fiber spreading analysis. Direct evaluation of re-replicated DNA molecules will promote increased understanding of events that promote or perturb genome stability.