cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Phosphodiesterases mediate neurohumoral regulation of sinoatrial node and atrial arrhythmogenesis
Creators: name: Dorey, Tristan W.
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Sinoatrial node
subject: atrial fibrillation
subject: autonomic nervous system
subject: phosphodiesterases
subject: cardiac electrophysiology
subject: natriuretic peptides
subject: Biology--Animal Physiology
subject: Biology--Cell
subject: Biology--Physiology
subject: Biophysics--General

description: Each heartbeat originates from a specialized region in the heart called the sinoatrial node (SAN) that is highly regulated by the autonomic nervous system (ANS). Hypertensive heart disease is the most common form of cardiovascular disease and impairs heart rate (HR) regulation. Inability to increase HR in response to various stressors is known as chronotropic incompetence and is linked to increased mortality risk in this population. Nevertheless, the mechanisms for chronotropic incompetence in this setting are unclear. As such, the first aim of this thesis was to characterize the mechanisms for impaired HR regulation in a mouse model of angiotensin II (AngII)-induced hypertensive heart disease. AngII-infused mice had intrinsic SAN dysfunction, increased sympathetic nervous system activity, and reduced SAN responsiveness to ANS stimulation. Mechanistically, reduced SAN responsiveness to sympathetic signaling in AngII-infused mice occurred due to upregulation of the enzyme phosphodiesterase 4D (PDE4D) in SAN myocytes, blunting catecholamine signalling. Inhibiting PDE4D activity and expression increased HR and SAN responses to catecholamine stimulation in AngII-infused mice, suggesting it may be a target for improving sympathetically mediated HR regulation in disease. Atrial fibrillation (AF) is the most common arrhythmia and frequently coexists with SAN dysfunction. While the ANS plays an important role in the generation of SAN and atrial arrhythmogenesis, endocrine factors can also contribute. Natriuretic peptides (NPs) are a family of cardioprotective hormones that act partially through NP receptor B (NPR-B), but NPR-B’s role in SAN function and atrial arrhythmogenesis is poorly understood. Thus, the second aim of this thesis was to characterize the role of NPR-B signaling on HR regulation and AF. NPR-B-deficient mice demonstrated intrinsic SAN dysfunction with reduced in vivo HR secondary to alterations in ion channel function in SAN cells. NPR-B-deficient mice were also highly susceptible to AF due to enhanced atrial catecholamine responses. Correspondingly, atrial NPR-B expression was reduced in humans with AF. Interestingly, activation of NPR-B antagonized catecholamine signaling in both mouse and human atrial myocytes. These studies highlight that NPR-B stimulation may be a novel approach for treatment and prevention of both SAN dysfunction and catecholamine-induced AF through distinct pathways.
Spin dependent transport in an electron gas with magnetic disorder
Creators: name: Berg, T. L. van den
name: Verga, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider a two dimensional semiconductor with carriers subject to spin-orbit interactions and scattered by randomly distributed magnetic impurities. We solve the time-dependent Schroedinger equation to investigate the relationship between the geometrical properties of the wavefunction and the system's spin dependent transport properties. Even in the absence of localized states, interference effects modify the carrier diffusion, as revealed by the appearance of power laws dependent on the impurity concentration. For stronger disorder, we find a localization transition characterized by a fractal wavefunction and enhanced spin transport.
description: 8 pages; 5 figures; CCT11 conference
Social Support for Physical Activity and Physical Literacy in Older Adults
Creators: name: Morrison, Lindsay
Publisher: name: Kinesiology
Year: 2022
Subjects: subject: Aging
subject: exercise
subject: age-friendly cities
subject: healthy aging
subject: recreation
subject: social relationships
subject: Behavioral
subject: Social
subject: Recreation
subject: Gerontology

description: Healthy and active aging is an increasingly important topic for policymakers and practitioners as the older adult population continues to grow. Maintaining physical activity participation and social connections can be imperative for aging well, and group physical activity can provide the opportunity for older adults to do both. Understanding how social experiences such as social support and social barriers affect older adults’ physical activity experiences is important for providing inclusive and accessible opportunities. Moreover, understanding the impact of COVID-19 on older adults’ physical activity and social participation may offer further insight for program designers and policymakers looking to support older adults. Study one employed a qualitative research design using interpretive description methodology to explore inactive older adults’ perspectives of social support, social barriers, and their effect on group physical activity experiences. Study two was comprised of an anonymous online cross-sectional survey that, using self-report and retrospective recall measures, investigated the changes in physical and social activity participation in the wake of COVID-19 and perceptions of precautionary measures and alternate forms of class delivery. These studies highlighted the diversity of perspectives amongst older adults, particularly regarding characteristics of group physical activity opportunities that can be considered motivating or intimidating. The findings show the impact of COVID-19 on older adults' physical activity and social participation, the features of group physical activity that can promote or hinder participation amongst older adults, and the value of social support tailored to specific needs. keywords: Aging, exercise, age-friendly cities, healthy aging, recreation, social relationships
title: Nephrometry Scoring System : interest in practice
Creators: name: Dkhil, Insaf
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Kidney
subject: CT
subject: Comparative studies
subject: Complications
subject: Surgery
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Introduce the Nephrometry scoring system as an objective reproducible means to describe a renal tumor Evaluate the correlations between nephrometry scores (PADUA and RENAL) and the operative difficulties and the post operative...
Solving the Naturalness Problem by Baby Universes in the Lorentzian Multiverse
Creators: name: Kawai, Hikaru
name: Okada, Takashi
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a solution of the naturalness problem in the context of the multiverse wavefunction without the anthropic argument. If we include microscopic wormhole configurations in the path integral, the wave function becomes a superposition of universes with various values of the coupling constants such as the cosmological constant, the parameters in the Higgs potential, and so on. We analyze the quantum state of the multiverse, and evaluate the density matrix of one universe. We show that the coupling constants induced by the wormholes are fixed in such a way that the density matrix is maximized. In particular, the cosmological constant, which is in general time-dependent, is chosen such that it takes an extremely small value in the far future. We also discuss the gauge hierarchy problem and the strong CP problem in this context. Our study predicts that the Higgs mass is 140\pm20 GeV and θ=0.
description: 35 pages, 11 figures. v2: added Section 5.3 with comments on the Wick rotation of the Lorentzian gravity. v3 some comments added
Bullwhip Effect in the Oil and Gas Supply Chain
Creators: name: Zhu, Tianyuan
Publisher: name: Haskayne School of Business
Year: 2021
Subjects: subject: Business Administration--Management

description: The bullwhip effect refers to the phenomenon where demand variability is amplified from downstream to upstream in the supply chain. My thesis consists of three studies investigating the bullwhip effect in different types of companies in the North American oil and gas supply chain. The first study of my thesis investigates the factors that impact the bullwhip effect in the oil and gas supply chain using case study evidence from six companies, covering refining and marketing, exploration and production, integrated oil and gas, and drilling. It is found that the existing theories of the bullwhip effect have limitations in explaining the phenomenon in the oil and gas industry. Information sharing, a widely advocated countermeasure of the bullwhip effect, may not be relevant in the integrated oil and gas company. The analysis also suggests that the bullwhip effect in companies involved in the oil and gas exploration and development activities mainly exists in orders of capital items or services related to capital investments. Financial factors considered in the capital budgeting process, such as the oil price and cash flow, play an important role in determining order quantities in these companies. Therefore, the second study of my thesis quantifies the firm-level bullwhip effect in orders of capital items or services related to capital investments, and examines the impacts of oil price and cash flow variabilities on the bullwhip effect in exploration and production, drilling, and oilfield service companies. The results show that the relationships between oil price variability and bullwhip effect and between cash flow variability and bullwhip effect are both non-linear and more complicated than previously proposed. The third paper of my thesis explores the relationship between the firm-level bullwhip effect in orders of capital items or services related to capital investments and firm performance in exploration and production, drilling, and oilfield service companies. Different from the previous results obtained in the manufacturing industries, it is found that the highest firm performance is not achieved when the bullwhip effect is largely smoothed, and the bullwhip effect influences the firm performance on the income side rather than the asset side.
title: The role of imaging in synovial disease
Creators: name: Díaz Antonio, Tania
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal system
subject: MR
subject: Ultrasound
subject: Conventional radiography
subject: Diagnostic procedure
subject: Biopsy
subject: Arthritides
subject: Hyperplasia / Hypertrophy
subject: Metabolic disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the characteristic imaging findings of synovial diseases to establish an early detection prior to irreversible joint damage, highlighting the role of ultrasound and magnetic resonance imaging both in the diagnosis and...
title: The imaging milestone in rectal cancer: How can MR discriminate patients at a higher risk for local recurrence from those eligible for rectal amputation or a “Wait and see” strategy
Creators: name: Ordones, Monique
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Radiation oncology in Developing Nations
subject: Cancer
subject: Radiation therapy / Oncology
subject: MR
subject: Oncology
subject: Colon
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Identify in the Magnetic Resonance Imaging (MRI) standardized protocol for rectal cancer the key anatomic landmarks and adverse features in primary staging and post-therapy reassessment. Review findings consistent with complete response following...
title: Central nervous system tuberculosis: image findings
Creators: name: Perry da Câmara, Catarina
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Neuroradiology spine
subject: MR
subject: MR-Diffusion/Perfusion
subject: Imaging sequences
subject: Complications
subject: Infection
subject: Abscess
subject: AIDS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To analyze central nervous system (CNS) tuberculosis manifestations’ spectrum by topography. To outline the most useful imaging characteristics fordifferential...
Conversando con Marta Dujovne
Creators: name: Magnani, Ilaria
Publisher: name: Università degli  Studi di Milano
Year: 2011

description: Conversando con Marta Dujovne
por Ilaria Magnani
description: Altre Modernità, No 5 (2011): Se il museo si fa teatro: la cultura del display tra conservazione e produzione
title: Can we predict if uterine fibroids might migrate after uterine artery embolisation?
Creators: name: Auyoung, Eric
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Genital / Reproductive system female
subject: Interventional vascular
subject: MR
subject: Embolisation
subject: Treatment effects
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Uterine artery embolisation (UAE) is an efficacious and less invasive alternative to surgery that results in infarction, coagulative necrosis, and eventual shrinkage of uterine fibroids [1,2]. The procedure is generally associated with a low risk of...
The mod 2 homology of infinite loopspaces
Creators: name: Kuhn, Nicholas J.
name: McCarty, Jason B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55P47 (Primary) 55S10, 55S12, 55T99 (Secondary)

description: We study the spectral sequence that one obtains by applying mod 2 homology to the Goodwillie tower which sends a spectrum X to the suspension spectrum of its 0th space X_0. This converges strongly to H_*(X_0) when X is 0-connected. The E^1 term is the homology of the extended powers of X, and thus is a well known functor of H_*(X), including structure as a bigraded Hopf algebra, a right module over the mod 2 Steenrod algebra A, and a left module over the Dyer-Lashof operations. Hopf algebra considerations show that all pages of the spectral sequence are primitively generated, with primitives equal to a subquotient of the primitives in E^1. We use an operad structure on the tower and the Z/2 Tate construction to show how Dyer-Lashof operations and differentials interact. These then determine differentials that hold for any spectrum X. These universal differentials then lead us to construct, for every A-module M, an algebraic spectral sequence depending functorially on M. The algebraic spectral sequence for H_*(X) agrees with the topological spectral sequence for X for many spectra, including suspension spectra and almost all generalized Eilenberg-MacLane spectra, and appears to give an upper bound in general. The E^infty term of the algebraic spectral sequence has form and structure similar to E^1, but now the right A-module structure is unstable. Our explicit formula involves the derived functors of destabilization as studied in the 1980's by W. Singer, J. Lannes and S. Zarati, and P. Goerss.
description: 45 pages, latest version has reorganized examples, and makes better use of Hopf algebra methods. Now appeared in AGT 13 (2013)
Additional file 1 of Inhibition of Japanese encephalitis virus proliferation by long non-coding RNA SUSAJ1 in PK-15 cells
Creators: name: Zhou, Xiaolong
name: Yuan, Qiongyu
name: Zhang, Chen
name: Dai, Zhenglie
name: Du, Chengtao
name: Wang, Han
name: Li, Xiangchen
name: Yang, Songbai
name: Zhao, Ayong
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1 Table S1: Sequences and parameters of primers.
Раскопки в Белой Церкви
Creators: name: Орлов, Руслан
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 430101
subject: Archaeological science

description: Орлов Р.С. Раскопки в Белой Церкви. Археологические открытия 1980 года. - М., 1981, с.295.Excavations in Bila Tserkva
title: Secondary postpartum/postabortion hemorrhage: when everything looks like an AVM
Creators: name: Nieto García, Carolina
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Haemorrhage
subject: Arteriovenous malformations
subject: Embolisation
subject: Ultrasound-Spectral Doppler
subject: MR-Angiography
subject: Catheter arteriography
subject: Vascular
subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: Genital / Reproductive system female

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the spectrum of radiologic findings in the different causes of secondary postpartum or postabortion hemorrhage (PPH), and to assess the need of performing a CT, an MRI or an angiography in case the ultrasound findings lead toward the...
Nonlinear cosmological consistency relations and effective matter stresses
Creators: name: Ballesteros, Guillermo
name: Hollenstein, Lukas
name: Jain, Rajeev Kumar
name: Kunz, Martin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a fully nonlinear framework to construct consistency relations for testing generic cosmological scenarios using the evolution of large scale structure. It is based on the covariant approach in combination with a frame that is purely given by the metric, the normal frame. As an example, we apply this framework to the LambdaCDM model, by extending the usual first order conditions on the metric potentials to second order, where the two potentials start to differ from each other. We argue that working in the normal frame is not only a practical choice but also helps with the physical interpretation of nonlinear dynamics. In this frame, effective pressures and anisotropic stresses appear at second order in perturbation theory, even for "pressureless" dust. We quantify their effect and compare them, for illustration, to the pressure of a generic clustering dark energy uid and the anisotropic stress in the DGP model. Besides, we also discuss the effect of a mismatch of the potentials on the determination of galaxy bias.
description: 36 pages. Extended discussion. Matches published version
Binary Response Models for Heterogeneous Panel Data with Interactive Fixed Effects
Creators: name: Gao, Jiti
name: Liu, Fei
name: peng, Bin
Publisher: name: Monash University
Year: 2022
Subjects: classificationCode: 380202
subject: Econometric and statistical methods
classificationCode: 380299
subject: Econometrics not elsewhere classified

description: In this paper, we investigate binary response models for heterogeneous panel data with interactive fixed effects by allowing both the cross sectional dimension and the temporal dimension to diverge. From a practical point of view, the proposed framework can be applied to predict the probability of corporate failure, conduct credit rating analysis, etc. Theoretically and methodologically, we establish a link between a maximum likelihood estimation and a least squares approach, provide a simple information criterion to detect the number of factors, and achieve the asymptotic distributions accordingly. In addition, we conduct intensive simulations to examine the theoretical findings. In the empirical study, we focus on the sign prediction of stock returns, and then use the results of sign forecast to conduct portfolio analysis. By implementing rolling-window based out–of–sample forecasts, we show the finite–sample performance and demonstrate the practical relevance of the proposed model and estimation method.
Miriam Clavir, Preserving What is Valued: Museums, Conservation, and First Nations
Creators: name: Gualtieri, Claudia
Publisher: name: Università degli  Studi di Milano
Year: 2011

description: Miriam Clavir, Preserving What is Valued: Museums, Conservation, and First Nations (UBC Press, Vancouver, 2002, 295 pp., ISBN 0-7748-0860-8 e 0-7748-0861-6)
di Claudia Gualtieri
description: Altre Modernità, No 5 (2011): Se il museo si fa teatro: la cultura del display tra conservazione e produzione
title: Calcaneal fractures: How to guide the orthopedist.
Creators: name: Mghaieth, Sandra
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Demineralisation-Bone
subject: Diagnostic procedure
subject: CT
subject: Musculoskeletal bone
subject: Bones
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aims of this exhibit are first to describe the normal multiplanar CT anatomy of the calcaneus; second to identify the CT features of calcaneal fractures and their treatment implications; and third to provide a structured CT report for calcaneal...
“It felt like a nightmare”: A Postcolonial and Transnational Feminist Examination of Repatriation Discourses in Kosova
Creators: name: Kusari, Kaltrina
Publisher: name: Social Work
Year: 2022
Subjects: subject: return migrants
subject: global power imbalances
subject: Kosova
subject: repatriation
subject: postcolonialism
subject: transnational feminism
subject: critical discourses analysis
subject: gender
subject: ethnicity
subject: Social Work
subject: FOS: Sociology
subject: Sociology--General
subject: Political Science--General

description: This qualitative study examined the experiences of return migrant women from Kosova, and service providers serving this population, in order to contribute to the paucity of literature on repatriation. Grounded in a postcolonial and transnational feminist theoretical framework and through a Critical Discourse Analysis of interviews with return migrant women and service providers, the study examined dominant discourses which shape the repatriation process in Kosova. The main findings illustrate that both returnee women and service providers are impacted by and contribute to discourses of repatriation voluntariness and sustainability, discourses of comparison, discourses of remigration, discourses of gender, and discourses of ethnicity. Returnee women use these discourses to give meaning to their experiences and navigate repatriation, while being impacted by the intersection of gender and ethnicity. Service providers rely on these discourses to legitimize official discourses which uphold repatriation as a sustainable solution to forced displacement. A postcolonial transnational feminist analysis of these discourses demonstrates that European Union countries use current repatriation policies and practice to uphold their superiority and impose Western standard on Kosova’s government and society. These findings add to the body of existing repatriation literature and provide important implications for social work practice, education, and theory.
Integration of Chinese agricultural commodity markets : a cointegration approach
Creators: name: Zheng, Chen
Publisher: name: University of British Columbia
Year: 2013

description: The integration of spatially separated markets was accelerated by intense trade in the last few decades. China started to open its markets since 1978 and now it plays an important role in world trade. However, China’s impact is less pronounced on agricultural commodity markets, and its impact varies across different commodities. This study discusses the prices performance of corn, soybean, and wheat in China and the U.S. We examine the integration process of Chinese agricultural commodity markets after China’s entry to WTO (i.e. 2004-2012). This study applies the cointegration test with and without a structural change. We detect the cointegration relationship between soybean prices in China and the U.S., but we observe such relationship does not exist in corn and wheat markets within China and the U.S.
Computation of exterior moduli of quadrilaterals
Creators: name: Hakula, Harri
name: Rasila, Antti
name: Vuorinen, Matti
Publisher: name: arXiv
Year: 2011
Subjects: subject: Numerical Analysis (math.NA)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 65E05, 31A15, 30C85

description: We study the problem of computing the exterior modulus of a bounded quadrilateral. We reduce this problem to the numerical solution of the Dirichlet-Neumann problem for the Laplace equation. Several experimental results, with error estimates, are reported. Our main method makes use of an $hp$-FEM algorithm, which enables computations in the case of complicated geometry. For simple geometries, good agreement with computational results based on the SC Toolbox, is observed. We also use the reciprocal error estimation method introduced in our earlier paper to validate our numerical results. In particular, exponential convergence, in accordance with the theory of Babu\vska and Guo, is demonstrated.
description: 19 pages, 12 figures, 7 tables
title: Low-dose breast density assessment
Creators: name: Hill, Melissa
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Breast
subject: Radiation physics
subject: Radioprotection / Radiation dose
subject: Mammography
subject: Efficacy studies
subject: Physics
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast density assessment is increasingly important to estimate risk of disease [1] and to triage women to appropriate screening modalities [2], but there are concerns about using ionising radiation for assessment of younger women due to the...
Mónica Lavín, Yo, la peor
Creators: name: González Luna, Anamarìa
Publisher: name: Università degli  Studi di Milano
Year: 2011

description: Mónica Lavín, Yo, la peor (México, Grijalbo, 2009, 379 pp. ISBN 978-607-429-298-)
di Anamaría González Luna
description: Altre Modernità, No 5 (2011): Se il museo si fa teatro: la cultura del display tra conservazione e produzione
Metabolomic Biomarkers Associated with Depression, Anxiety, and Smoking Exposure in Pregnancy
Creators: name: Laketic, Katarina L.
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Pregnancy
subject: Metabolomics
subject: Depression
subject: Anxiety
subject: Smoking
subject: Metabolism
subject: Nuclear Magnetic Resonance
subject: Inductively Coupled Plasma Mass Spectrometry
subject: Education--Sciences
subject: Biology--Physiology
subject: Health Sciences--Mental Health

description: Nearly 400,000 Canadian women become pregnant annually, with approximately 25% reporting poor mental health (Study 1) and 6% reporting smoking (Study 2) during their pregnancy. Both poor mental health and smoking exposure lead to a higher risk of detrimental pregnancy outcomes, and long-term effects on the mothers' and offspring’s health. Although the mechanisms underlying these health complications are still under investigation, metabolite disruption and metabolic pathway alterations in the metabolome are thought to be implicated. As the metabolome has the power to capture subtle changes in metabolite concentrations, it provides a real-time functional portrait of the organism. As a novel approach, metabolomics would allow us to comprehensively characterize metabolites within biological systems and further our limited understanding of the pathophysiology associated with poor mental health and smoking exposure. Third-trimester serum was collected and assessed via two analytical platforms: proton nuclear magnetic resonance spectroscopy (1H-NMR) and inductively coupled plasma-mass spectrometry (ICP-MS), to study how depression, anxiety, and smoking exposure affect the metabolome and metallome. Key findings showed unique metabolomic signatures associated with depression and anxiety status, and distinctive metallomic and trace element signatures associated with varying smoking exposures. Although further validation is required due to the exploratory nature of both studies, the metabolomics approaches employed in this thesis provided insights into mental health and smoking effects on maternal and birth-related outcomes which ultimately may serve as future diagnostic and screening tools.
title: The validation of a Microwave Breast Imaging System Prior to a First-In-Human Trial
Creators: name: Moloney, Brian
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Cancer
subject: Equipment
subject: Experimental
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Microwave imaging is a non-ionising modality which offers insight into the dielectric properties of tissue. The exciting potential of dielectric property discrepancies between normal breast parenchyma and the breast cancer has been investigated for...
title: High faecal calprotectin levels and the intestinal wall thickening: is there a relationship in paediatric patients with cystic fibrosis?
Creators: name: Angelini, Valentina
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Paediatric
subject: Gastrointestinal tract
subject: Abdomen
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Observer performance

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Cystic fibrosis (CF) is a disease of secretory glands caused by mutation of the cystic fibrosis transmembrane regulator (CFTR) gene. The clinical manifestations of CF are repetitive lung infections, biliary cirrhosis, pancreatic abnormalities and...
Optimization of A Volatile Organic Compound (VOC) Control Strategy in Eight Cities of Western Canada by Multi-Effects Evaluation
Creators: name: Xiong, Ying
Publisher: name: Schulich School of Engineering
Year: 2021
Subjects: subject: VOCs
subject: source identification
subject: ozone and SOA formation potential
subject: health risk assessment
subject: multi-effect evaluation.
subject: Atmospheric Sciences
subject: FOS: Earth and related environmental sciences
subject: Environmental Sciences
subject: Health Sciences--General

description: Volatile organic compounds (VOCs) in large urban environments are of great interest to the public and research communities, as they can contribute to ground-level ozone (O3) and secondary organic aerosol (SOA) formation and promote adverse health effects. To this end, this thesis investigates the spatiotemporal variations, O3 and SOA formation potentials (FP), and health risks of VOCs in western Canada based on a six-year (2013-2018) routinely monitored data collected by Environment and Climate Change Canada. Overall, the concentrations of VOCs showed significant spatial and temporal differences across western Canada. Industrial and traffic sites exhibited much higher concentrations than urban centers and background sites. Using a newly developed tiered source identification strategy, seven VOC sources were identified in western Canada. The OFP and SOAFP of the measured VOCs were then assessed; the dominant VOC sources (i.e., industrial-related emissions and vehicle exhausts) accounted for 71.8% and 77.0% of OFP and SOAFP, respectively. This finding suggests the need to control VOC emissions from these sources once O3 or fine particle exceeds their air quality standards. Moreover, regionally transported VOCs have greatly increased the VOC level and secondary pollutant formation in western Canada. To effectively alleviate secondary pollution problems, the implementation of joint pollution control measures has been suggested by the local authorities. Although chronic non-cancer risks associated with exposure to hazardous VOCs were essentially negligible, the integrated inhalation cancer risk (ICR) was estimated at 7.7×10-5 in western Canada, which indicates a 100% likelihood of exceeding the Health Canada acceptable risk level. The probability of developing cancer due to inhalation of hazardous VOCs increased 4-fold on polluted days relative to clean air days. From a risk management perspective, the concentrations of hazardous VOCs and associated sources need to undergo reductions of 78.3-91.0% and 3.0–69.2%, respectively. Taken together, results of multi-effects evaluation suggest that stringent control of VOCs sources, particularly traffic sources and industrial-related emissions, is an urgent priority in western Canada. The tiered source identification and multi-effects evaluation methodology developed in this thesis is a promising tool for optimizing VOC control strategies, which can be applied toward improved management of hazardous pollutants.
title: Thoracic and abdominal emergencies in cancer patients: that we have to say the radiologists
Creators: name: Cabrera Canal, Fernando
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Embolism / Thrombosis
subject: Pathology
subject: Acute
subject: Education
subject: Diagnostic procedure
subject: Complications
subject: MR
subject: Digital radiography
subject: CT
subject: Thorax
subject: Emergency
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe and illustrate the image findings associated with thoracic and abdominal emergencies in cancer...
Development of Smart Hydrogels with Tunable Properties for Cartilage Tissue Engineering
Creators: name: Rana, Md Mohosin
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: cartilage
subject: tissue engineering
subject: hydrogel
subject: thermoresponsive polymer
subject: green synthesis
subject: cellulose
subject: stem cells
subject: chondrogenesis
subject: Health Sciences--General
subject: Chemistry--Organic
subject: Chemistry--General

description: Cartilage is avascular with poor regenerative capabilities. Therefore, a scaffold providing a cartilage-like microenvironment is needed to facilitate the regeneration of damaged cartilage.Poly(N-isopropylacrylamide) (PNIPAm) hydrogels provide an aqueous, crosslinked, and three-dimensional environment with many desirable physicochemical properties needed for tissue engineering, but have poor mechanical strength and limited biocompatibility. Crosslinking PNIPAm with cellulose or cellulose derivatives can enhance its mechanical properties. Cellulose-based biomaterials are biocompatible and have tunable mechanical properties. The goal of this thesis is to develop a mechanically strong and biocompatible hybrid scaffold using PNIPAm and cellulose. Initially, the effect of synthesis-solvent polarity on the properties of PNIPAm microgels were investigated. Microgels synthesized in dioxane and toluene showed a unique crosslinked network that resulted in cartilage-like stiffness. Due to the toxicity of these conventional solvents, and their potential negative effects for in vivo applications, it is desirable to avoid their use. A novel synthesis route was developed to synthesize fully functional PNIPAm microgels using the green bio-based solvent 2-methyltetrahydrofuran (2-MeTHF). Three different crosslinking densities with varying NIPAm to N,N’-methylenebisacrylamide (MBAA) ratios were tested. The swelling degree increased with increasing crosslinking density, which is an atypical behaviour. This may be due to a variation in the relative abundance of amide and isopropyl groups in the microgel network.Next, attention was shifted to developing hybrid PNIPAm-cellulose microgels with enhanced mechanical properties. Amorphized cellulose (AC) was produced by treating microcrystalline cellulose with 1-butyl-3methylimmidazolium chloride. AC-g-PNIPAm interpenetrating polymer network (IPN) microgels with a high swelling degree and a higher stiffness were synthesized by tuning the AC content and crystallinity. Finally, ATDC5 cells were cultured in these IPN scaffolds and analyzed the expression of three gene expression markers, i.e., Prrx1, Sox9, and Osterix. Microgels containing 10 and 15 % AC with 41.7 % crystallinity exhibit superior performance in terms of cell viability and chondrogenic gene (Sox9) expression. Thus, this study demonstrates that tuning the rheological properties of AC-g-PNIPAm microgels by controlling the cellulose content and crystallinity is an effective strategy to develop mechanically superior scaffolds for cartilage tissue engineering.
Schimke immuno-osseous dysplasia : association of SMARCAL1 mutations with genetic and environmental disturbances of gene expression
Creators: name: Baradaran-Heravi, Alireza
Publisher: name: University of British Columbia
Year: 2013

description: Schimke immuno-osseous dysplasia (SIOD, MIM 242900) is an incompletely penetrant autosomal recessive multisystem disorder characterized by dysmorphic facies, short stature, renal failure, and T-cell immunodeficiency. Biallelic loss-of-function mutations in SMARCAL1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin, subfamily a-like 1), which encodes a DNA stress response enzyme with annealing helicase activity, are associated with SIOD. My studies focused on further delineation of the molecular basis of SIOD by assessing the contribution of defective DNA repair to the pathophysiology of SIOD and a mechanism by which SMARCAL1 can modulate trait penetrance. Through collaborative analyses of the clinical data and molecular studies of SIOD patients, my coworkers and I observed that SIOD patients have a high frequency of non-Hodgkin lymphoma and showed that despite similarities among SIOD and other DNA repair diseases, SMARCAL1-deficient cells do not have increased baseline DNA breaks detectable by comet assay. Additionally, SIOD patients do not have a detectable defect of nucleotide excision repair (NER), homologous recombination (HR) or nonhomologous end joining (NHEJ) to explain their ectodermal or immunological features, although Smarcal1-deficient mice are hypersensitive to several DNA damaging agents. Furthermore, my colleagues and I found that SMARCAL1 orthologues localize to transcriptionally active chromatin and modulate gene expression, that deficiency of the SMARCAL1 orthologues alone is insufficient to cause disease in fruit flies and mice, that SMARCAL1 deficiency causes modest diffuse alterations in gene expression, and that SMARCAL1 deficiency causes disease via interaction with genetic and environmental factors that further alter gene expression. In summary, our findings provide guidance for clinical management of SIOD and suggest that alterations in the variance of gene expression levels contribute to the penetrance of SIOD.
transcriptome of of roots and shoots response to gravity in Salix matsudana
Creators: name: 刘国元(Guoyuan Liu)
Publisher: name: CNGB
Year: 2021
Subjects: Raw sequence reads
Multiisolate
Agricultural

description: Normal and inverted cuts of Salix matsudana (Koidz) were cultured. Total RNAs of roots and shoots were extracted for transcriptome analysis.
Sensitive imaging of electromagnetic fields with paramagnetic polar molecules
Creators: name: Alyabyshev, Sergey V.
name: Lemeshko, Mikhail
name: Krems, Roman V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We propose a method for sensitive parallel detection of low-frequency electromagnetic fields based on the fine structure interactions in paramagnetic polar molecules. Compared to the recently implemented scheme employing ultracold $^{87}$Rb atoms [B{ö}hi \textit{et al.}, Appl. Phys. Lett. \textbf{97}, 051101 (2010)], the technique based on molecules offers a 100-fold higher sensitivity, the possibility to measure both the electric and magnetic field components, and a probe of a wide range of frequencies from the dc limit to the THz regime.
María Negroni, Galería fantástica
Creators: name: Rocco, Federica
Publisher: name: Università degli  Studi di Milano
Year: 2011

description: María Negroni, Galería fantástica (México, Siglo XXI editores, 2009, 110 pp. ISBN 9786070300776)
di Federica Rocco
description: Altre Modernità, No 5 (2011): Se il museo si fa teatro: la cultura del display tra conservazione e produzione
SU(3) Gauge Family Symmetry and Prediction for the Lepton-Flavor Mixing and Neutrino Masses with Maximal Spontaneous CP Violation
Creators: name: Wu, Yue-Liang
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A model for the lepton-flavor mixing and CP violation is proposed based on the SU$_F$(3) gauge family symmetry and the Majorana feature of neutrinos. A consistent prediction for the lepton-flavor mixing and masses is shown to be resulted from the appropriate vacuum structure of SU$_F$(3) gauge symmetry breaking. By choosing the SU$_F$(3) gauge fixing condition to possess a residual $Z_2$ symmetry and requiring the vacuum structure of spontaneous symmetry breaking to have approximate global U(1) family symmetries, we obtain naturally the tri-bimaximal mixing matrix and largely degenerate neutrino masses in the neutrino sector and the small mixing matrix in the charged-lepton sector. With a simple ansatz that all the smallness due to the approximate global U(1) family symmetries is characterized by a single Wolfenstein parameter $λ\simeq 0.22$, and the charged-lepton mixing matrix has a similar hierarchy structure as the CKM quark mixing matrix, we arrive at a consistent prediction for the MNSP lepton-flavor mixing with a maximal spontaneous CP violation: $δ=π/2$, $\sin^2θ_{13} \simeq 1/2λ^2 \simeq 0.024$ ($\sin^22θ_{13} \simeq 0.094$), $\sin^2θ_{12} \simeq 1/3{3}(1 - 2λ^3) \simeq 0.326$ and $\sin^2θ_{23} \simeq 1/2(1 - λ^2) \simeq 0.48$, which agree well with the current experimental data. The CP-violating Jarlskog-invariant is obtained to be $J_{CP} \simeq 1/6λ(1-λ^2/2-λ^3)\sinδ\simeq 0.035$, which is detectable in next generation neutrino experiment. The largely degenerate neutrino masses with the normal hierarchy and inverse hierarchy are discussed and found be at the order $m_{ν_i} \simeq O(λ^2) \simeq 0.04\sim 0.06$ eV with a total mass $\sum m_ν \sim 0.15$ eV, which is testable in future precision astrophysics and cosmology.
description: 14 pages, it is explicitly shown that the smallness for both the charged-lepton mixing and neutrino masses with the standard seesaw mechanism can naturally be explained by the approximate global U(1) family symmetries of vacuum structure in the SU(3) gauge family model, references added, published version in PLB
A Mixed Methods Analysis of Barriers and Facilitators to Scholarly Education in Orthopaedic Surgery Residency
Creators: name: Morrison, Laura J
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Research
subject: Scholar
subject: Scholarly Education
subject: Post-Graduate Medical Education
subject: Orthopaedic Surgery
subject: Health Sciences--Education
subject: Health Sciences--Medicine and Surgery

description: Background: According to the CanMEDS framework of physician competency, and the objectives of training determined by the Royal College of Physicians and Surgeons of Canada, each orthopaedic surgery resident must conduct ‘scholarly work’ during residency. Best practices in scholarly education in residency recommend having a Resident Research Director, access to administrative and financial supports, protected research time, and regular journal clubs. This study aimed to answer the following research questions: (1) What is the current state of scholarly education in Canadian orthopaedic surgery residency training programs (OSRTPs)? and (2) How and why do programs adhere to, or deviate from, best practices identified in the literature?Methods: We employed a convergent mixed methods study design using a questionnaire and interviews to nationally sample residents and educators, respectively. The quantitative and qualitative data were collected and analyzed separately, before being merged to identify themes. Descriptive statistics were calculated from the total number of completed responses in each item on the questionnaire. We used thematic analysis as described by Braun and Clarke to search for themes within the free-text responses in the questionnaire as well as the interviews. Results: In total, 117 out of 328 residents (36%) from the 17 Canadian OSRTPS, ranging from post-graduate year one (PGY1) to five (PGY5), responded to the questionnaire. Twelve interviews were conducted with 10 Resident Research Directors and two Program Directors. Combined analysis of the questionnaire results and the interview transcripts revealed five themes: three barriers (insufficient protected time, fragmented educational resources, and unexpected restrictions) and two facilitators (an understanding of unique learner needs and a culture of scholarship) to achieving success in scholarly education.Conclusion: Though the importance of scholarly work in post-graduate medical education has long been recognized, it has only recently become a necessary competency with defined objectives. The results from this study and emerging recommendations can be utilized to highlight existing strengths and support curricular changes to improve scholarly education in residency training programs.
Wick(ed) Children. Strane storie per giovani lettori
Creators: name: Grossi, Alessandra
Publisher: name: Università degli  Studi di Milano
Year: 2011

description: Wick(ed) Children. Strane storie per giovani lettori. A cura di Nicoletta Vallorani (Milano, Skira, 2010, pp. 83)
di Alessandra Grossi
description: Altre Modernità, No 5 (2011): Se il museo si fa teatro: la cultura del display tra conservazione e produzione