cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gesamtentwicklung Traktoren = Agricultural Tractor Development
Creators: name: Stirnimann, Roger
Publisher: name: Technische Universität Braunschweig, Institut für mobile Maschinen und Nutzfahrzeuge
Year: 2024
Subjects: Traktorenmarkt
Traktortechnik
Traktortrends
alternative Antriebskonzepte
Batterieelektrik

description: In Deutschland wurden 2023 fast genau gleich viele Traktoren neu zugelassen wie im Vorjahr. Alternative Antriebskonzepte waren wiederum vieldiskutierte Themen und es wurden verschiedene Prototypen/Studien vorgestellt. Batterieelektrische Traktoren im unteren Leistungsbereich erreichen nach und nach die Serienreife. Zur Anwendung kommt derzeit hauptsächlich das "conversion design" mit zentralem E-Motor und klassischer Getriebe-Hinterachse-Einheit. Fendt stellte die komplett neue 4-Zylinder-Baureihe 600 Vario vor und schiebt den 4-/6-Zylinder-Übergang damit weiter nach oben. Weitere Highlights waren die schweren Zugtraktoren von Case IH und Claas (Quadtrac 715 resp. XERION 12er-Serie) sowie die neuen Großtraktoren von Massey Ferguson und Valtra (9S resp. S-Serie).
description: In Germany, almost exactly the same number of new tractors were registered in 2023 as in the previous year. Alternative drive concepts were again a much-discussed topic and various prototypes/studies were presented. Battery-electric tractors in the lower power range are gradually reaching series maturity. Currently, the "conversion design" with a central electric motor and classic transmission / rear axle unit is mainly used. Fendt presented the completely new 4-cylinder 600 Vario series and is pushing the 4-/6-cylinder transition further upwards. Other highlights included the heavy-duty tractors from Case IH and Claas (Quadtrac 715 and XERION 12 series respectively) and the new large tractors from Massey Ferguson and Valtra (9S and S series respectively).
Cost-effectiveness of diet plus exercise versus diet alone on the reduction of ectopic fat deposition in adults with overweight: study protocol of a trial based health economic evaluation
Creators: name: Hens, W.
name: Vissers, D.
name: Annemans, L.
name: Gielen, J.
name: Van Gaal, L.
name: Taeymans, Jan
Publisher: name: Georg Thieme Verlag
Year: 2017

description: Background: Excess ectopic fat deposition is associated with the development of cardiovascular and metabolic diseases. This study investigates the added value of exercise to diet on ectopic fat reduction and metabolic factors. Objective: The purpose of this report is to present and discuss the rationale, design and methods of this randomized controlled trial and cost-effectiveness analysis. Method: Participanùs: Endocrinologists of the University Hospital of Antwerp are recruiting premenopausal women during consultations. Intervention: 60 potential participants meeting all a priori set inclusion and exclusion criteria are randomized by minimization method to get usual care (hypocaloric diet) or combined therapy (hypocaloric diet and physical fitness training) during 6 months. Outcome measures: Primary outcomes include ectopic fat deposition (intramyocellular lipids, intra hepatic lipids, epicardial adipose tissue and visceral adipose tissue) objectively assessed by imaging techniques. Patients were instructed to record all health-related care and costs through diaries. Secondary outcome parameters are metabolic parameters, anthropometrics and lifestyle parameters assessed by clinical examinations, blood analyses, anthropometric measures, questionnaires and activity trackers. Results/Conclusions: This is the first trial discussing the added value of supervised exercise to hypocaloric diet on ectopic fat deposition and secondary health parameters. Clinical and economic results are presented as changes in ectopic fat deposition, metabolic risk profile and qualityadjusted life years. This RCT provides novel evidence for the use of supervised exercise interventions besides energy restriction in people with overweight.
Schritt für Schritt mehr Verbindlichkeit in der Sozialhilfe
Creators: name: Coullery, Pascal
Publisher: name: Avenir Social
Year: 2019

description: In den letzten rund 100 Jahren sind immer wieder Versuche unternommen worden, die Sozialhilfe zumindest in den Grundzügen auf Bundesebene zu regeln. Alle Versuche sind gescheitert, der Handlungsbedarf besteht aber nach wie vor
Megachile (Carinula) fervida Smith 1853
Creators: name: Nkulu, Alain Tshibungu
name: Pauly, Alain
name: Dorchin, Achik
name: Vereecken, Nicolas J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Megachilidae
Megachile
Megachile fervida

description: Megachile (Carinula) fervida Smith, 1853
Chalicodoma (Carinella) fervida (Smith, 1853)
Material. Cabinet 110, Drawer 25 (1 ♀). D.R. CONGO.— Haut-Katanga • 1 ♀; Elisabethville (Lubumbashi); riv. Kimilolo; -11.67, 27.47; 6 Nov. 1920; Dr. M. Bequaert leg.; RMCA.
description: Published as part of Nkulu, Alain Tshibungu, Pauly, Alain, Dorchin, Achik & Vereecken, Nicolas J., 2023, The Megachilidae (Hymenoptera, Apoidea, Apiformes) of the Democratic Republic of Congo curated at the Royal Museum for Central Africa (RMCA, Belgium), pp. 1-103 in Zootaxa 5392 (1) on page 45, DOI: 10.11646/zootaxa.5392.1.1, http://zenodo.org/record/10435063
title: "Testa di giovane", Beccafumi Domenico, inv. 453 (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Puddu, Pier Ludovico
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Des pistes vertes pour protéger le bois
Grüne Wege, das Holz zu schützen
Creators: name: Noël, Marion
Publisher: name: BFH
Year: 2018

description: L’utilisation du bois est reconnue pour son impact positif sur l’environnement et le bien-être. Mais plusieurs verrous freinent encore son emploi. Parmi eux, sa propension à se dégrader est un facteur limitant qu’il est difficile de contrer par des méthodes non toxiques. Depuis l’idée innovante jusqu’aux premiers essais de mise en œuvre, la BFH propose un traitement biosourcé très efficace.
description: Der Einsatz von Holz ist bekannt für einen positiven Einfluss auf Umwelt und Wohlbefinden. Aber verschiedene Hürden bremsen immer noch die Verwendung des Baustoffs. Darunter fällt, dass Holz dazu neigt zu zerfallen. Dem ohne giftige Behandlungsmethoden zu begegnen, ist schwierig. Von der innovativen Idee bis zu ersten Umsetzungsversuchen - die BFH wartet mit einer sehr wirksamen, biobasierten Behandlung auf.
Bestandesaufnahme der Fallführungssysteme im Hinblick auf die Erreichung der Ziele der Integrationsagenda
Creators: name: Fritschi, Tobias
name: Champion, Cyrielle
name: Neuenschwander, Peter
Publisher: name: Berner Fachhochschule BFH, Soziale Arbeit
Year: 2020

description: Das Staatssekretariat für Migration SEM und die Konferenz der Kantonsregierungen KDK haben im Frühjahr 2018 gemeinsam die Integrationsagenda IAS lanciert. Ihre Umsetzung in den Kantonen sollte durch die Fallführungssysteme möglichst gut unterstützt werden können. Um den dargestellten Anforderungen der IAS an die Fallführung und das Monitoring gerecht zu werden, sind die Kantone auf geeignete Fallführungssysteme im Sinn von IT-Lösungen angewiesen. Der vorliegende Bericht stellt die Ergebnisse einer Bestandesaufnahme von Fallführungssystemen in den Kantonen dar.
Shifting Realities
Creators: name: Melzer, Tine
Publisher: name: University of Amsterdam & TU Delft
Year: 2022

description: it influences our minds, our linguistic practices, and our worldviews. Melzer’s current research project ‘Atlas of Aspect Change’ reflects shifting meanings viewed through the prism of language and intersubjective exchange. It elicits phenomena of perspective and reveals how words and images influence each other. It activates understanding of complex and ambiguous situations and shows how to stimulate and refine interdisciplinary discourse.
Das grosse Schweigen
Creators: name: Gautschi, Nadine
Publisher: name: Berner Fachhochschule, Soziale Arbeit
Year: 2022

description: Bis 1981 wurden in der Schweiz zehntausende Kinder und Jugendliche auf Bauernhöfen verdingt oder in Einrichtungen und Pflegefamilien fremdplatziert. Die Betroffenen verschwiegen dies vielfach selbst gegenüber ihren eigenen Kindern. Wie ist es, wenn die eigenen Eltern nicht über ihre traumatischen Erfahrungen sprechen?
CareConnection: A Digital Caring Community Platform to Overcome Barriers of Asking for, Accepting and Giving Help
Creators: name: Aal, Tanja
name: Ruhl, Andrea
name: Kohler, Erich
name: Choudhary, Apurva
name: Bhandari, Pragya
name: Devbhankar, Namrata
name: Egli, Silvia
name: Gashi, Shkumbin
name: Kaspar, Heidi
name: Spittel, Madlen
name: Kirschsieper, Dennis
name: Müller, Claudia
Publisher: name: Association for Computing Machinery
Year: 2023

description: Many people would like to remain in their familiar surroundings in old age, even if they need certain forms of assistance. But what exactly does everyday life look like, where are the hurdles and where can community-based support options start? The results of a citizen-based participatory interview study of community members of a rural Living Lab near Zurich, Switzerland and full-time researchers from two universities in Switzerland and Germany explore these questions. Results of the study relate to physical limitations and potentials in old age, aspects of well-being and mental health, social engagement, relationships and networks, as well as the theme of ‘asking for help, accepting help and giving help’. Against the background of a key category, the barriers of ‘asking for, accepting and giving help’, an overarching reflection by the co-researchers and full-time researchers took place. This focus provided the basis for the participatory development of CareConnection, a digital community platform design that fosters social exchange and helps to overcome identified barriers, which can be physical, mental or social and within these categories temporal, spatial, structural and/or individual and thus enable or promote social encounters and interaction to establish a higher level of well-being and health.
Barriers and facilitators of maternal healthcare utilisation in the perinatal period among women with social disadvantage: A theory-guided systematic review
Creators: name: Grand-Guillaume-Perrenoud, Jean Anthony
name: Origlia Ikhilor, Paola
name: Cignacco Müller, Eva
Publisher: name: Elsevier
Year: 2022
Subjects: Barriers
facilitators
healthcare access
healthcare utilisation
social disadvantage
perinatal period

description: Background: Women with social disadvantage have poorer perinatal outcomes compared to women in advantaged social positions, which may be linked to poorer healthcare utilisation. Disadvantaged groups may experience a greater diversity of barriers (e.g., feeling embarrassed about pregnancy, lack of transportation) or barriers judged to be particularly difficult (e.g., embarrassment about pregnancy). They may also experience barriers more frequently (e.g., depression). Using Levesque et al.’s (2013) framework of healthcare access, our review identifies the barriers and facilitators that affect maternal healthcare utilisation in the perinatal period among women with social disadvantage in high-income nations. Objectives: Our review searches for the barriers and facilitators affecting maternal healthcare utilisation in the perinatal period, from pregnancy to the first year postpartum, among women with social disadvantage (Prospero registration CRD42020151506). Design: We conducted a theory-guided systematic review. PubMed, Embase, MEDLINE, PsycINFO, and Social Science Citation Index databases were searched for publications between 1999 and 2018. Findings: 37 articles out of 12’972 were included in the qualitative synthesis. 19 domains of barriers and facilitators were extracted. Domains on the provider side includes ‘information regarding available treatments’ and ‘trustful relationships.’ On the user-side, domains include ‘awareness of pregnancy’ and ‘unplanned/unwanted pregnancy’ Key conclusions: Provider- and user-side characteristics interact to affect access. User-side characteristics that pose a barrier can be offset by provider-side characteristics that lower barriers to access. Implications for practice: User-side characteristics (e.g., lack of awareness of pregnancy) play an important role in the initial steps toward access. Among women with social disadvantage, reducing barriers may require active outreach on the part of providers.
«Learning from Corona» – ein Wissenschaftsblog zu Designfragen rund um die Pandemie
Creators: name: Kaufmann, Beatrice
Year: 2021
Subjects: Health Care Communication Design HCCD
Learning From Corona
Wissenschaftsblog
Wissenschaftskommunikation

description: Von der Krisenkommunikation in Pandemiezeiten über den Einfluss von Design auf die Funktionsfähigkeit von Intensivstationen bis zu den Arbeitsbedingungen des Ge­ sundheitspersonals: Der Wissenschaftsblog «Learning from Corona» (https://hccd. hypotheses.org) behandelt Themen rund um das Design in der aktuellen Pandemie sowie Fragestellungen im Gesundheitswesen, die durch die Krise besonders sichtbar wurden. Der Blog wird von der Arbeitsgruppe Health Care Communication Design (HCCD) der Berner Fachhochschule betrieben, die interdisziplinär zu Fragen rund um Gesundheit und Gestaltung forscht. Seit April 2020 macht «Learning from Corona» anhand der aktuellen Pandemie die Expertise der Arbeitsgruppe HCCD einer breiten Öffentlichkeit zugänglich. Der geplante Speed­Talk präsentiert den Blog am Beispiel einer Beitragsserie zu Datenvisualisierung und Infografiken. Dabei werden historische Beispiele von Daten­ visualisierungen von Krankheit und Mortalität genauso thematisiert wie die visuelle Aufbereitung von komplexen Informationen anhand aktueller Beispiele rund um die Pandemie. Weitere Beiträge der Serie widmen sich datengetriebenem Journalismus sowie parodistischen Äusserungen im Look traditioneller Infografiken. Der Fokus liegt dabei auf den aktuellen Herausforderungen und Möglichkeiten zeitgenössischer Info­ grafiken.
Megachile (Carinula) junodi Friese 1904
Creators: name: Nkulu, Alain Tshibungu
name: Pauly, Alain
name: Dorchin, Achik
name: Vereecken, Nicolas J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Megachilidae
Megachile
Megachile junodi

description: Megachile (Carinula) junodi Friese, 1904
Chalicodoma (Carinella) junodi (Friese, 1904)
Material. Cabinet 110, Drawer 25(1 ♀ and 2♂). D.R. CONGO — Haut-Katanga • 1 ♀; Elisabethville (Lubumbashi); -11.67, 27.47; 12 Oct. 1934; P. Quarré leg.; RMCA • 1 ♂; PNU Masombwe s. Grde. Kafwe; -9.08, 27.20, alt. 1120 m; 4/ 16 Jan. 1948; Mis. G.F. de Witte leg.; RMCA.— Haut-Lomami • 1 ♂; Sankisia; -9.40, 25.80; 4 Sep. 1911; Dr. J. Bequaert leg.; RMCA.
description: Published as part of Nkulu, Alain Tshibungu, Pauly, Alain, Dorchin, Achik & Vereecken, Nicolas J., 2023, The Megachilidae (Hymenoptera, Apoidea, Apiformes) of the Democratic Republic of Congo curated at the Royal Museum for Central Africa (RMCA, Belgium), pp. 1-103 in Zootaxa 5392 (1) on page 45, DOI: 10.11646/zootaxa.5392.1.1, http://zenodo.org/record/10435063
Grossmehrheitlich positiv
Wirkungen von Integrationsprogrammen in der Sozialhilfe aus Sicht der Teilnehmenden
Creators: name: Neuenschwander, Peter
Publisher: name: Avenir Social
Year: 2018

description: Die Berner Fachhochschule hat in einer Studie die erwünschten und unerwünschten Wirkungen von Integrationsprogrammen in der Sozialhilfe untersucht. Die Studie wurde von Innosuisse unterstützt, der im Auftrag des Bundes tätigen Schweizerischen Agentur für Innovationsförderung.
Dipterocarpeae Rchb., Handb. Nat. Pfl.
Creators: name: Cvetković, Tijana
name: Hinsinger, Damien D.
name: Thomas, Daniel C.
name: Wieringa, Jan J.
name: Velautham, Elango
name: Strijk, Joeri S.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malvales
Dipterocarpaceae

description: Tribe Dipterocarpeae Rchb., Handb. Nat. Pfl. -Syst.: 304.
1837 – Type: Dipterocarpus C.F.Gaertn.
Emergent or canopy trees, columnar but hardly buttressed with untidy globose crowns; prominently lenticellate orange– brown massively flaky bark; large leaf buds; amplexicaul bud scales; furnished stipules with diverse species-defining indumenta; plicate venation resulting in corrugation of their coriaceous leaves; thickly geniculate and often long petioles with often complex rings of vascular bundles and resin canals; variously thickened calyx ornamentations (tubercules, simple or folded wings); large flowers bearing a tubular calyx united at base into a smooth, angled, tuberculate or flanged tube enclosing but free from the ovary; two aliform, valvate sepals all along their development; stamens (15–40) are elongate orange anthers and stout tapering connectival appendages; dispersed resin canals in the wood and the largest stamens are the unique characteristic for Dipterocarpus; chromosome number n = 11 (summarized in Heckenhauer & al., 2017). From India and Sri Lanka to SE Asia.
One genus: Dipterocarpus C.F.Gaertn.
description: Published as part of Cvetković, Tijana, Hinsinger, Damien D., Thomas, Daniel C., Wieringa, Jan J., Velautham, Elango & Strijk, Joeri S., 2022, Phylogenomics and a revised tribal classification of subfamily Dipterocarpoideae (Dipterocarpaceae), pp. 85-102 in TAXON 71 (1) on page 92, DOI: 10.1002/tax.12648, http://zenodo.org/record/14047441
Narratives on leaving care in Switzerland: Biographies and discourses in the 20th century
Creators: name: Keller, Samuel
name: Gabriel, Thomas
name: Bombach, Clara
Publisher: name: Wiley-Blackwell
Year: 2021

description: Research on institutional care and its long-term effect on life trajectories provides crucial and sometimes unexpected insights. In a qualitative study in Switzerland, we have conducted 37 narrative interviews with people who experienced residential care between 1950 and 1990. The analysis was based on a reconstructive life course perspective and grounded theory. The findings show a complex interplay of residential care context (here: narratives from expert discourses) and intersubjective experiences during and after care. Most interviewees learned from their experiences to be sceptical of social relationships and of all kinds of state interventions—even decades after having left. A few were able to take charge of their lives and steer them in an individually successful direction. In these cases too, results point to fragile concepts of success. Thus, critical questions about residential care in these decades remain. We suggest that rather than abolish residential care facilities, we need to gather more evidence about the factors that contribute to high-quality out-of-home-placements. As professional settings, they can enable young people individually. They need to avoid responding to children as ‘objects of care’, by neglecting all subjective dimensions and reproducing a pattern of powerlessness with a strong focus on formal, measurable goals.
Targeting caspase pathway by novel N-Me aziridine derivatives for hepatocellular carcinoma drug discovery
Creators: name: Kumar, Pranesh
name: Faruqui, Tabrez
name: Yadav, Ajay K.
name: Chandra, Dinesh
name: Verma, Saumya
name: Saha, Sudipta
name: Jat, Jawahar L.
name: Akhter, Yusuf
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Azaheterocycles are three-membered rings, known as aziridines, that occur naturally and have pharmaceutical applications.These compounds are present as several secondary metabolites produced by plants and microorganisms.Recent studies have demonstrated the effectiveness of aziridine derivatives (N-H/N-Me) as anticancer agents.We synthesized 18 compounds containing an N-Me enone aziridine group, the chemistry of which has been previously published. However, these compounds have drug-likeness properties; therefore, we aimed to demonstrate their drug-like properties using in silico and in vitro investigations.The molecular structures of the compounds were optimized using density functional theory (DFT). The ADMET parameters of the derivatives were calculated using SwissADME and PreADMET. Additionally, these derivatives were evaluated for their ability to bind to caspase-3 and caspase-9 and then subjected to molecular docking. The lead chemical AY128 maintained stable complexes with target proteins during molecular dynamics simulations, as evidenced by the root mean square deviation (RMSD) and root mean square fluctuation (RMSF) parameters. In vitro cytotoxicity and ELISA tests showed that the novel aziridine derivatives, especially AY128, had strong anticancer activity against HepG2 hepatocellular carcinoma cells.Our study suggests that AY128 may be a potential drug candidate for hepatocellular carcinoma through the caspase-3 and caspase-9-dependent apoptotic pathways. Communicated by Ramaswamy H. Sarma
"Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment"
Creators: name: Ritu
name: Chandra, Prakash
name: Das, Asmita
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Virology

description: Cancer is a leading cause of mortality worldwide, and various anticancer medications have been developed that target different biological pathways involved in cancer growth and progression. Topoisomerase 1 (Top1) is an essential enzyme involved in unwinding supercoiled DNA, and it serves as a key target for several anti-cancer drugs. Irinotecan (FDA approved drug), a semi-synthetic camptothecin derivative, is an effective Top1 toxin that eliminates human cancer cells. Cancer patients suffer from the cholinergic syndrome caused by irinotecan and other Top1 inhibitors. Irinotecan-treated patients have developed cholinergic syndrome due to acetylcholinesterase (AChE) enzyme inhibition. It appears that irinotecan or its metabolites directly interact with AChE and inhibit its role of converting acetylcholine to choline, leading to an accumulation of acetylcholine and subsequent symptoms of the cholinergic syndrome. The phytochemicals present in Phyllanthus emblica, commonly referred to as amla, have been studied to determine their therapeutic effects. As an alternative treatment for cancer, this study explores the potential of phytochemicals found in amla to target and inhibit the Top1 protein. Additionally, the study aims to identify a non-inhibitor for AChE. Molecular docking studies assessed phytochemical binding affinities to Top1 and AChE enzymes, and ADME analyses were performed to assess their drug-likeness properties. Subsequently, molecular dynamic simulation was employed to assess the stability of these compounds. The results suggest that new anticancer medications that do not inhibit AChE or fresh Top1 inhibitors that use the camptothecin scaffold may alleviate some of the irinotecan’s side effects. Communicated by Ramaswamy H. Sarma
Dryobalanopseae Baill., Hist. Pl.
Creators: name: Cvetković, Tijana
name: Hinsinger, Damien D.
name: Thomas, Daniel C.
name: Wieringa, Jan J.
name: Velautham, Elango
name: Strijk, Joeri S.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malvales
Dipterocarpaceae

description: Tribe Dryobalanopseae Baill., Hist. Pl. 4: 210, 213. 1873 –
Type: Dryobalanops C.F.Gaertn.
Emergent or canopy; fibres are with bordered pits; scattered resin canals; solitary vessels; fruit sepal is thickened. The subvalvate sepals in fruit (imbricate at first, after only retaining some traces of imbrication) is a unique characteristic for Dryobalanops. Chromosome number n = 7. Native in W. Malesia.
Note: The name Dryobalanopseae was incorrect and superfluous when published, since it included Dipterocarpus, but it was validly published with the correct name on page 213 and the description on 210, and is available for a tribe containing Dryobalanops and not Dipterocarpus; see Art. 19 Note 3 of the ICN (Turland & al., 2018).
One genus: Dryobalanops C.F.Gaertn.
description: Published as part of Cvetković, Tijana, Hinsinger, Damien D., Thomas, Daniel C., Wieringa, Jan J., Velautham, Elango & Strijk, Joeri S., 2022, Phylogenomics and a revised tribal classification of subfamily Dipterocarpoideae (Dipterocarpaceae), pp. 85-102 in TAXON 71 (1) on page 92, DOI: 10.1002/tax.12648, http://zenodo.org/record/14047441
Gaming and Digital Public History
Creators: name: Nolden, Nico
name: Pfister, Eugen
Publisher: name: De Gruyter Oldenbourg
Year: 2022

description: Over the past 50 years the part of digital games in our everyday’s media use has consistently grown. They are thus an extremely revealing source for public history. This chapter argues that digital games are among other things a ‘historical form.’ They are not merely products of entertainment, but as cultural artifacts communicate perceptions of history. Digital games are also ‘historical sources.’ Because they are developed from the inside of societies, they are shaped by cultures and politics. Furthermore, digital games are ‘historical research tools’. Historical simulations can help to understand historical structures and processes. There are however practical, methodical and technical challenges for public historians. Historians must have a comprehensive knowledge of a vast field of academic disciplines from game and media studies, political sciences, sociology to anthropology and philosophy. A historical analysis of games must search for historical game influences but also for other historical conditions and influences.
SKOS vocabulary without SKOS training. A tool for everyone.
Creators: name: Koukouli, Myrto
name: Katifori, Akrivi
name: Ioannidis, Yannis
Publisher: name: Zenodo
Year: 2024
Subjects: subject: SKOS
subject: Controlled Vocabularies
subject: Linked Data
subject: Semantic web
subject: Software applications

description: Controlled vocabularies play a crucial part in most, if not all, activities connected to Cultural Heritage. Advances in Linked Data and Semantic Web technologies made it possible for vocabularies to be shared and reused. Today, a variety of well structured and accessible vocabularies, such as the Getty Art & Architecture Thesaurus, are available for experts and organizations to use. These are often quite extensive so, in most cases, a subset of the vocabularies is used. Furthermore, since controlled vocabularies are considered best practice in a wide variety of activities, the experts or organizations often rely on more than one sources to create their own vocabularies to better cover their specific domain or the scope of their application. The creation of such custom vocabularies in the form of Linked Data requires at least some understanding of the Semantic Web technologies. To face this problem, we present a software application that enables any user to create a SKOS vocabulary without prior knowledge of RDF, SKOS or Linked Data. The users can easily build a hierarchical vocabulary from scratch, view the concepts tree and add extra attributes to each concept. Since this project is still in the development stage, our goal is to present its current status, hoping to receive feedback and maybe provoke discussions about the part of Cultural Heritage that remains “hidden" from the Semantic Web.
Novel dihydrobenzofuran derivatives: design, synthesis, cytotoxic activity, apoptosis, molecular modelling and DNA binding studies
Creators: name: Rana, Manish
name: Ansari, Imran
name: Twala, Charmy
name: Khan, Sumbul
name: Mandal, Anupam
name: Rahisuddin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Pyrazoline derivatives (3a–3e) and (4a–4e) were designed and synthesized through chalcones (2a–2e) cyclization with NH2NH2/HCOOH and NH2CSNHNH2/CH3COOH, respectively. The molecular structures were elucidated by using various techniques such as UV–visible, FT-IR, 1H, 13C NMR spectroscopy and mass spectrometry. The purity of all synthesized compounds was checked by the liquid chromatography–mass spectrometry (LC–MS). Single X-ray crystallography was confirmed the molecular structure of analogs (2d, 3e and 4e). Anticancer activity of the all derivatives was screened against human cancer cell MCF-7 and HepG2 cell lines by MTT assay. The results of anticancer activity of novel analogs 2b, 3b and 3e exhibited promising activity against MCF-7 but low toxic against the HepG2 normal cell line. By using a flow cytometry-based technique, the anticancer effectiveness of potent compounds against the MCF-7 cancer cell line was further validated. DNA binding interactions of the novel analogs 3b and 3e were carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence, circular dichroism and cyclic voltammetry. In silico molecular modelling of pyrazoline derivatives were also studied using Schrödinger-Maestro v2021-2 against tyrosine kinase receptor with PDB ID: 1M17 to explore their best hits. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical was used to measure the antioxidant capacity of active pyrazoline derivatives. Using Swiss ADMET software, the ADMET characteristics of pyrazoline derivatives were also investigated. Communicated by Ramaswamy H. Sarma
Shoreeae Miq., Fl. Ned. Ind.
Creators: name: Cvetković, Tijana
name: Hinsinger, Damien D.
name: Thomas, Daniel C.
name: Wieringa, Jan J.
name: Velautham, Elango
name: Strijk, Joeri S.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malvales
Dipterocarpaceae

description: Tribe Shoreeae Miq., Fl. Ned. Ind. 1(2): 503. 1859
– Type: Shorea Roxb. ex C.F.Gaertn.
= [unranked] Hopeae Korth., Verh. Nat. Gesch. Ned. Bezitt., Bot.: 55. 1840.
– “Parashoreeae” Takht., Flowering Pl.: 269. 2009, nom. nud. – Based on Parashorea Kurz.
Emergent or canopy, understorey trees; resin canals in tangential bands; thickened sepal base; fruit sepals imbricate at the incrassate-cupped base of the ripe fruit; 3 strata in pollen exine: absent tilioid structure of exine; T and Y columellae shape-type; always grouped vessels with cellular divisions; radial canal formation; 2 or 3 incrassate bases of sepals (and accrescent sepals) in fruits; free bases of fruit sepals; frigid pericarp tissue; circular fruit equatorial section; embryo cotyledons “coveringpiled”; inferior or median-inferior hypocotyl; bilobed seedling cotyledons; 4 root-xylem poles; uni- to tri-lacunar cotyledonary vascular bundles; stomatal types in first leaves paracytic, or para-cyclocytic, or anomo-cyclocytic; elongate stomata, sunken in the epiderm; chromosome number n = 7 (summarized in Appanah & Turnbull, 1998). From India and Sri Lanka to Malesia.
Eight genera: Anthoshorea Pierre (synonym of Shorea), Doona Thwaites (synonym of Shorea), Hopea Roxb., Neobalanocarpus P.S.Ashton, Parashorea Kurz, Richetioides F.Heim (synonym of Shorea), Rubroshorea (synonym of Shorea), Shorea Roxb. ex C.F.Gaertn.
Notes: Hopeae, described by Korthals (1839 –1842), would have had priority over Shoreeae but was described without explicit rank, which is mandatory before 1887 (Art. 37.1–37.3 of the ICN, Turland & al., 2018).
Shoreeae has also been spelled as ‘Shoreae’. Given this name has a non-Latin base (named after Sir John Shore), but has been Latinized, where the stem is the single syllable Shore, it seems proper to follow the original spelling of Miquel, who also used ‘Shoreeae’. In case we consider this name to have alternative possible genitives, Art. 18.1 (via Art. 17.1) even obliges us to do so. In botanical Latin, double ee’ s are often avoided, but many recent tribal names based on generic names ending on -ea have also regularly been formed including the double ee. Since Parashorea is derived from Shorea, a tribe named after it should be spelled with the double ee as well, but so far this name lacks a formal description and is not in alignment with our classification superfluous.
description: Published as part of Cvetković, Tijana, Hinsinger, Damien D., Thomas, Daniel C., Wieringa, Jan J., Velautham, Elango & Strijk, Joeri S., 2022, Phylogenomics and a revised tribal classification of subfamily Dipterocarpoideae (Dipterocarpaceae), pp. 85-102 in TAXON 71 (1) on pages 92-93, DOI: 10.1002/tax.12648, http://zenodo.org/record/14047441
Exploring the potential of machine learning to design antidiabetic molecules: a comprehensive study with experimental validation
Creators: name: Devaraji, Vinod
name: Sivaraman, Jayanthi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Recent advances in hardware and software algorithms have led to the rise of data-driven approaches for designing therapeutic modalities. One of the major causes of human mortality is diabetes. Thus, there is a tremendous opportunity for research into effective antidiabetic designs. Therefore, in this study, we used machine learning-based small molecule design. We used various chemoinformatic and binary fingerprint techniques on small molecules to construct multiple models for alpha-amylase inhibitors. Among these models, the top models were used for ensemble-based machine learning predictions on libraries of organic molecules supplemented with synthetic scaffolds that could be used as antidiabetic agents. Further, involved identifying 10 promising molecules from computational studies and determining their inhibitory effects on alpha-amylase. These molecules were synthesised and thoroughly analysed to assess their biological inhibitory properties. Then, thermodynamic simulations were conducted to determine the stability and affinity of experimentally active molecules. The research results showcased the top 10 ML models recorded impressive statistics with an average model score of 0.8216, Pearson-r value of 0.827 and external validation yielding a Q2 value of 0.835, proving their reliability and accuracy. Ten derivatives of benzothiophene dioxolane was prime research focus due to computational predictions. The biological inhibitory assay of synthesised molecules showed that small molecules with ID ALC5 and ALC6 exhibited inhibitory efficiencies (IC50) of 2.1 ± 0.14 µM and 5.71 ± 0.02 µM against alpha-amylase enzyme, whereas other molecules showed moderate inhibition. In conclusion, the positive results of the experiment indicate that researchers should explore machine learning-driven design. Communicated by Ramaswamy H. Sarma
Alters- und Pflegeheime in der Covid-19-Pandemie
Creators: name: Zumstein-Shaha, Maya
name: Monteverde, Settimio
Publisher: name: Hogrefe
Year: 2021

description: Nachfolgend werden Herausforderungen bezüglich des Schutzes der Bewohnenden von Alters- und Pflegeheimen, ihren Bezugspersonen sowie der Fachpersonen identifiziert. Daraus folgende Überlegungen können zeigen, wie Alters- und Pflegeheime auch in einer schweren Public Health-Krise wieder oder neu als Orte des Lebens und des Sterbens gedacht werden können, die dem Wohl, den Interessen und der Würde aller Betroffener gerecht werden.
Vaterieae Miq., Fl. Ned. Ind.
Creators: name: Cvetković, Tijana
name: Hinsinger, Damien D.
name: Thomas, Daniel C.
name: Wieringa, Jan J.
name: Velautham, Elango
name: Strijk, Joeri S.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malvales
Dipterocarpaceae

description: Tribe Vaterieae Miq., Fl. Ned. Ind. 1(2): 502. 1859
– Type: Vateria L. [see note].
= Anisoptereae Miq., Fl. Ned. Ind. 1(2): 500. 1859 – Type:
Anisoptera Korth.
Emergent or canopy trees; pollen grains tricolpate and lack endexine; universal presence of intercellular resin canals; valvate base of sepals in calyx of ripe fruit (imbricate at first, after only retain some traces of imbrication); solitary vessels, scattered resin canals; pericarp thickenings; 2 strata in pollen exine; tilioid structure of exine; columellae shape-type V and U; solitary vessels with cellular divisions of canal formation oblique; 0 or 5 incrassate bases of sepals (and accrescent sepals) in fruits; fused bases of fruit sepals; rigid to soft pericarp tissue; circular to 3-symmetric fruit equatorial section; cotyledons in embryo neither covering nor piled; hypocotyl apical or median; seedling cotyledons entire; 6, 8 or 10 root-xylem poles; 3- to multilacunar cotyledonary vascular bundles; stomatal types in first leaves anomocytic or anisocytic; elongate stomata; and sunken in the epiderm (imbricate) or round and raised above the epiderm (valvate); chromosome number n = 11 (summarized in Appanah & Turnbull, 1998). From the Seychelles through India and Sri Lanka to SE Asia.
Note: Miquel (1859) seems to have taken up the name from Korthals (1839), who had described the unranked name Vaterieae for a group containing Vateria and Retinodendron Korth. Subsequently, Blume (1852) used Vaterieae, but as a subfamily name (“subord.”) that included both Vateria and Vatica. Miquel was the first to explicitly use the term at tribal level, and provided a new description. Since in this work he only had to deal with some species of Vatica (Vateria does not occur in Indonesia), it is not immediately apparent here that it is based on Vateria instead of Vatica. Since Vaterieae is only the correct tribe name when it is based on the generic name Vateria, and it likely is a classification following previous works of Korthals and Blume, we consider Vateria the type of the tribe, and hence Vaterieae the correct spelling.
Seven genera: Anisoptera Korth., Cotylelobium Pierre, Stemonoporus Thwaites, Upuna Symington, Vateria L., Vateriopsis F.Heim, Vatica L.
description: Published as part of Cvetković, Tijana, Hinsinger, Damien D., Thomas, Daniel C., Wieringa, Jan J., Velautham, Elango & Strijk, Joeri S., 2022, Phylogenomics and a revised tribal classification of subfamily Dipterocarpoideae (Dipterocarpaceae), pp. 85-102 in TAXON 71 (1) on page 93, DOI: 10.1002/tax.12648, http://zenodo.org/record/14047441
Gynoplistia Westwood 1835
Creators: name: Billingham, Zacariah D.
name: Theischinger, Gunther
name: Levesque-Beaudin, Valerie
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Limoniidae
Gynoplistia

description: Genus Gynoplistia Westwood, 1835
Type species: Gynoplistia vilis Walker, 1835, subsequent designation by Brunetti, 1918.
Diagnosis. Rostrum markedly shorter than remainder of head; antennae with more than 11 flagellomeres; eyes glabrous; tibial spurs present; cell C without supernumerary crossveins; Sc l absent or much shorter than Rs; Sc ending beyond origin of Rs; four branches of R reaching the wing margin; no X-shaped vein crossing formed by R l, R l+2 and R 3; R 2 present; R 2+3+4 markedly shorter than R 4 and mostly shorter than basal section of R 5; r-m present; mcu some distance before apex of discal medial cell (modified from Theischinger 1993). Hypopygium with paramere and interbase apparently fused (Ribeiro 2008).
Gynoplistia includes over 300 species, occurring across the Australasian and Neotropic biogeographic realms. Their diversity is greatest in Australia and New Zealand, with 116 and 108 species recorded respectively (Oosterbroek 2023). All Australian species of Gynoplistia are endemic.
Theischinger (1993) completed an extensive review of the Australian Gynoplistia, describing many new species and providing a key to the subgenera and species groups. Following Theischinger’s review additional new species have been described over several works (Billingham & Theischinger 2017, 2018a; Theischinger 1994, 1999, 2000).
Gynoplistia is readily distinguished from other Australian limoniid genera using the key provided in Theischinger (1996b).
description: Published as part of Billingham, Zacariah D., Theischinger, Gunther & Levesque-Beaudin, Valerie, 2023, Two new species of crane fly (Diptera: Limoniidae) from Tasmania, Australia, pp. 77-83 in Zootaxa 5256 (1) on page 78, DOI: 10.11646/zootaxa.5256.1.5, http://zenodo.org/record/7752370
Elucidating the conformational dynamics of histo-blood group antigens and their interactions with the rotavirus spike protein through computational lens
Creators: name: Poddar, Sayan
name: Roy, Rajarshi
name: Kar, Parimal
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: In the present study, we investigated the conformational dynamics of histo-blood group antigens (HBGAs) and their interactions with the VP8* domain of four rotavirus genotypes (P[4], P[6], P[19], and P[11]) utilizing all-atom molecular dynamics simulations in explicit water. Our study revealed distinct changes in the dynamic behavior of the same glycan due to linkage variations. We observed that LNFPI HBGA having a terminal β linkage shows two dominant conformations after complexation, whereas only one was obtained for LNFPI with a terminal α linkage. Interestingly, both variants displayed a single dominant structure in the free state. Similarly, LNT and LNnT show a shift in their dihedral linkage profile between their two terminal monosaccharides because of a change in the linkage from β(1–3) to β(1–4). The molecular mechanics generalized Born surface area (MM/GBSA) calculations yielded the highest binding affinity for LNFPI(β)/P[6] (−13.93 kcal/mol) due to the formation of numerous hydrogen bonds between VP8* and HBGAs. LNnT binds more strongly to P[11] (−12.88 kcal/mol) than LNT (−4.41 kcal/mol), suggesting a single change in the glycan linkage might impact its binding profile significantly. We have also identified critical amino acids and monosaccharides (Gal and GlcNAc) that contributed significantly to the protein-ligand binding through the per-residue decomposition of binding free energy. Moreover, we found that the interaction between the same glycan and different protein receptors within the same rotavirus genogroup influenced the micro-level dynamics of the glycan. Overall, our study helps a deeper understanding of the H-type HBGA and rotavirus spike protein interaction. Communicated by Ramaswamy H. Sarma
Molecular level investigation for identifying potential inhibitors against thymidylate kinase of monkeypox through in silico approaches
Creators: name: Koirala, Suman
name: Samanta, Sunanda
name: Mahapatra, Subhasmita
name: Ursal, Kapil Dattatray
name: Poddar, Sayan
name: Kar, Parimal
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The need for more advanced and effective monkeypox (Mpox) treatments has become evident with numerous Mpox virus (MPXV) outbreaks. Over the years, interest has increased in developing targeted medicines that are efficient, safe, and precise while avoiding adverse effects. Here, we screened 32409 compounds against thymidylate kinase (TMPK), an emerging target for Mpox treatment. We studied their pharmacological characteristics and analyzed those through all-atom molecular dynamics simulations followed by molecular mechanics Poisson Boltzmann surface area (MM-PBSA) based free energy calculations. According to our findings, the leads CID40777874 and CID28960001 had the highest binding affinities towards TMPK with ΔGbind of −8.04 and −5.58 kcal/mol, respectively, which outperformed our control drug cidofovir (ΔGbind = −2.92 kcal/mol) in terms of binding favourability. Additionally, we observed crucial TMPK dynamics brought on by ligand-binding and identified key residues such as Phe68 and Tyr101 as the critical points of the protein-ligand interaction. The DCCM analysis revealed the role of ligand binding in stabilizing TMPK’s binding region, as indicated by residual correlation motions. Moreover, the PSN analysis revealed that the interaction with ligand induces changes in residual network properties, enhancing the stability of complexes. We successfully identified novel compounds that may serve as potential building blocks for constructing contemporary antivirals against MPXV and highlighted the molecular mechanisms underlying their binding with TMPK. Overall, our findings will play a significant role in advancing the development of new therapies against Mpox and facilitating a comprehensive understanding of their interaction patterns. Communicated by Ramaswamy H. Sarma
TriSt: Transienten im Stromnetz
Creators: name: Schori, Stefan
name: Acuña, Jorge
name: Buntschu, Ron Bruno
name: Höckel, Michael
Year: 2023

description: Durch dieses Vorprojekt konnte gezeigt werden, dass Transienten fast überall im Stromnetz auftreten. Es konnten keine eindeutigen Störungen identifiziert werden, welche im direkten Zusammenhang mit dem Auftreten der Transienten stehen. Ob es in verschiedenen Verteilnetzen zeitgleich zu Ereignissen kommt, konnte nicht beurteilt werden, da sich die erhaltenen Messdaten nicht ausreichend zeitlich überlagern. Die meisten Transienten wurden nahe beim Verbraucher, also am Hausanschlusskasten gemessen. Dabei ist unklar, ob sie auch lokal verursacht oder lediglich durch die Reaktion von Geräten lokal verstärkt werden. Bei einem Laborversuch wurde gezeigt, dass nichtlineare Geräte mit hohen Stromspitzen auf Transienten reagieren können. Es wurde eine Methode zur Auswertung der Transienten entwickelt, sodass die Spannungs- und die Stromänderung quantifiziert und charakterisiert werden können.