cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Does secondhand smoke induce epigenetic changes?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Secondhand smoke (SHS) has long been linked to lung cancer and other diseases in nonsmokers and represents a serious public health concern. Besides causing DNA damage and mutation, SHS can induce other molecular changes (namely epigenetic changes) that may lead to cancer development. This is an unexplored area of research that requires further investigation. In this application, we propose a unique and innovative study aiming to gain preliminary data on impact of SHS on epigenetic changes, which has enormous public health relevance. The studies described in this “Pilot Research Award” application will investigate, for the first time, the cancer-causing potential of SHS, through epigenetic mechanisms, in a validated mouse model. Using state-of-the-art technologies, we will leverage our collection of lung specimens from mice sub-chronically exposed to SHS smoke and measure reversible and irreversible molecular changes that are known to be associated with cancer. The completion of the studies described in this application will help us verify whether the adverse consequences of SHS exposure are mediated by epigenetic mechanisms and device strategies for intervention.
Kalmijn_online_supplement – Supplemental material for Family Complexity into Adulthood: The Central Role of Mothers in Shaping Intergenerational Ties
Creators: name: Kalmijn, Matthijs
name: Leeuw, Suzanne G. De
name: Hornstra, Maaike
name: Ivanova, Katya
name: Gaalen, Ruben Van
name: Houdt, Kirsten Van
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, Kalmijn_online_supplement for Family Complexity into Adulthood: The Central Role of Mothers in Shaping Intergenerational Ties by Matthijs Kalmijn, Suzanne G. de Leeuw, Maaike Hornstra, Katya Ivanova, Ruben van Gaalen and Kirsten van Houdt in American Sociological Review
Additional file 5 of Needs for mobile and internet-based psychological intervention in patients with self-injury and suicide-related behaviors: a qualitative systematic review
Creators: name: Luo, Meiqi
name: Yue, Yuchuan
name: Du, Na
name: Xiao, Yu
name: Chen, Chunyan
name: Huan, Zongsu
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 5. One of the themes of qualitative synthesis: Advanced needs.
Unraveling the mechanisms of Cefoxitin resistance in methicillin-resistant Staphylococcus aureus (MRSA): structural and molecular simulation-based insights
Creators: name: Alshabrmi, Fahad M
name: Alatawi, Eid A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Methicillin-resistant Staphylococcus aureus (MRSA) severely affects human health, including the skin glands, nasal cavity, wound infections, bone infections, and pneumonia. Among the most effective MRSA drugs, Cefoxitin also develops resistance due to mutations in the mecA gene. Four mutations at positions E229K, E239R, G246K, and E447K are classified as high-level resistance mutations. However, the resistance mechanism of MRSA towards Cefoxitin caused by these mutations is still unclear, as there is less information available regarding the structural and functional effects of the mutations against Cefoxitin. Therefore, our present study was designed to explore the mechanisms of binding interactions between wild-type and mutated PBP2a against Cefoxitin using molecular docking and MD simulations. Subsequently, we identified that the mutant form of PBP2a affects the activity of Cefoxitin. Interestingly, the binding of Cefoxitin with G246K and E239R mutants demonstrates unstable behavior compared to E447K-Cefoxitin and E229K-Cefoxitin. In this study, we propose the resistance mechanism of Cefoxitin at the atomic level. The proposed drug-resistance mechanism will provide valuable guidance for the design of MRSA drugs. This research might provide a new framework for designing new agents against the mutated form of PBP2a. Communicated by Ramaswamy H. Sarma
In silico molecular docking, molecular dynamics, ADMET analysis of fucoidan against receptor frizzled-8 and coreceptor LRP6 in Wnt/β-Catenin pathway and in vitro analysis of fucoidan extract from Sargassum echinocarpum as β-catenin inhibitor in breast cancer cell line (MCF-7)
Creators: name: Laeliocattleya, Rosalina Ariesta
name: Yunianta, Yunianta
name: Risjani, Yenny
name: Wulan, Siti Narsito
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: This study aimed to investigate the effect of fucoidan on the Wnt/β-Catenin pathway using both in-silico molecular docking, molecular dynamics, ADMET analysis (in frizzled-8 receptor and LRP6 coreceptor) and in-vitro experiments using MCF-7 breast cancer cells. Through the molecular docking analysis, the binding energies on the frizzled-8 receptor were −5.6, −5.1, −9.4, and −8.8 kcal/mol, respectively. Meanwhile, those on the LRP6 receptor, were −7.3, −6.2, −10.0, and −9.8 kcal/mol, respectively. The results showed that fucoidan had a favorable binding affinity for both receptors. Furthermore, it was discovered to reduce the interaction and binding affinity between Wnt agonists to frizzled-8 and LRP6 receptors. This reduction was reflected in the change in the binding energy of the fucoidan-Wnt agonist-frizzled 8 and fucoidan-Wnt agonist-LRP6 complexes, which exhibited decreases of −7.0 kcal/mol and −7.8 kcal/mol, respectively. Fucoidan was found stable in complexes with frizzled-8 receptor and co-receptor LRP6. ADMET study showed it’s non-carcinogenic and can be distributed in the body. Fucoidan effectively inhibited β-catenin production, a critical factor in the Wnt/β-catenin pathway. The MCF-7 breast cancer cells were treated with fucoidan extract from S. echinocarpum at incubation times of 24, 48, and 72 h, resulting in a reduction of β-catenin levels by 95.19%, 83.88%, and 80.88%, respectively. Fucoidan also shows no significant difference in value compared to fucoidan standard (F. vesiculosus) and doxorubicin. Fucoidan exhibited antiproliferative effects against breast cancer cells, specifically through its modulation of the Wnt/β-Catenin pathway, and held great potential as an herbal anticancer agent. Communicated by Ramaswamy H. Sarma
MPEC 2024-K151 : 2017 RP2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Supplemental Material, Groth_Supplementary_Tables - Predictors of the Clinical Course of Tourette Syndrome: A Longitudinal Study
Creators: name: Groth, Camilla
name: Skov, Liselotte
name: Lange, Theis
name: Debes, Nanette M.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111403 Paediatrics
subject: Neuroscience

description: Supplemental Material, Groth_Supplementary_Tables for Predictors of the Clinical Course of Tourette Syndrome: A Longitudinal Study by Camilla Groth, Liselotte Skov, Theis Lange and Nanette M. Debes in Journal of Child Neurology
Equivariant correspondences and the Borel–Bott–Weil theorem
Creators: name: Emerson, Heath
name: Yuncken, Robert
Publisher: name: Mathematisches Institut (Universität Münster)
Year: 2017
Subjects: 510 Mathematik

description: We prove an analog of the Borel–Bott–Weil theorem in equivariant KK-theory by constructing certain canonical equivariant correspondences between minimal flag varieties G/B, with G a complex semisimple Lie group.
Highlights – Supplemental material for Reliability evaluation of reinforced concrete columns designed by Eurocode for wind-dominated combination considering randomloads eccentricity
Creators: name: Jiang, Youbao
name: Peng, Suixiang
name: Beer, Michael
name: Wang, Lei
name: Zhang, Jianren
Publisher: name: SAGE Journals
Year: 2019
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, Highlights for Reliability evaluation of reinforced concrete columns designed by Eurocode for wind-dominated combination considering randomloads eccentricity by Youbao Jiang, Suixiang Peng, Michael Beer, Lei Wang and Jianren Zhang in Advances in Structural Engineering
Biomolecular interactions between the antibacterial ceftolozane and the human inflammatory disease target ADAM17: a drug repurposing study
Creators: name: Sunil, Ahsan Anjoom
name: Jose, Deepthi
name: Karri, Sai Kumar
name: Pukhraj, Pukhraj
name: Varughese, Jibin K.
name: Skaria, Tom
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Inhibition of a disintegrin and metalloproteinase-17 (ADAM17), a metzincin, is proposed as a novel therapeutic strategy to suppress overproduction of the proinflammatory cytokine TNF-α in rheumatoid arthritis and inflammatory bowel disease. Existing ADAM17 inhibitors generate toxic metabolites in-vivo or haven’t progressed in clinical trials. Previous studies suggest that ligands which bind to ADAM17 active site by interacting with the Zn ion and L-shaped hydrophobic S1’- and S3’-pockets and forming favorable hydrogen bonds could act as potential ADAM17 inhibitors. Here, we investigated whether the FDA-approved anti-bacterial drug ceftolozane, a cephalosporin containing aromatic groups and carboxyl groups as probable zinc binding groups (ZBGs), forms non-covalent interactions resulting in its binding in the active site of ADAM17. In this study, the density functional theory (DFT), molecular docking and molecular dynamics calculations with the catalytic chain of ADAM17 show that carboxyl group of ceftolozane acts as moderate ZBG, and its extended geometry forms hydrogen bonds and hydrophobic interactions resulting in a binding affinity comparable to the co-crystallized known ADAM17 inhibitor. The favorable binding interactions identified here suggest the potential of ceftolozane to modulate ADAM17 activity in inflammatory diseases. ADAM17 cleaves and releases epidermal growth factor (EGF) ligands from the cell surface. The shed EGF ligands then bind to the EGF receptors to drive embryonic development. Therefore, our findings also suggest that use of ceftolozane during pregnancy may inhibit ADAM17-mediated shedding of EGF and thus increase the risk of birth defects in humans. Communicated by Ramaswamy H. Sarma
Breast Health and the Environment Among Latinas in Los Angeles: Mapping Disparities and Systems
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Breast cancer is the most common cancer and the leading cause of cancer deaths among Latina women in the US and the rates are increasing. Risk factors such as environmental hazards, racism, poverty and stress may play roles for understanding increase breast cancer rates among Latinas. The Breast Health and the Environment Among Latinas in Los Angeles: Mapping Disparities and Systems project will build on a community-academic partnership to increase capacity to assess the impacts of environmental racism and systemic factors on women’s breast cancer risk and inform collaborative public health actions in South Los Angeles. This brings together strong partnerships between Esperanza Community Housing, based in South Los Angeles and University of Southern California Department of Population and Public Health Sciences together with local community health workers to advance understanding of neighborhood factors that influence breast cancer health among Latina women. Esperanza and USC will build upon collaborative efforts to continue to expand community participatory research capacity to explore place-based hazards and structural systems that influence on breast health of Latinas in South Los Angeles. With community health workers, we will convene a Community Action Board to co-develop a future research agenda to environmental exposures, disparities, and breast health. We will facilitate a bilingual symposium among residents, community organizations, public health officials, health care professionals and researchers to map systems together with social and environmental burdens that influence breast cancer among this population. This project will lead to developing of a Phase II proposal to identify key opportunities to implement community-engaged and place-based strategies to reduce local breast cancer risk factors among Latinas in South Los Angeles with leadership from local community health workers.
Leveraging Community Assets to Reduce Financial Toxicity among Hispanic Breast Cancer Survivors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Introduction: Financial toxicity, the unintended financial burdens of cancer care, is greater among racial/ethnic minorities. Hispanic individuals, particularly Spanish speaking breast cancer (BC) survivors living in rural regions, often experience additional challenges such as, travel distance. However rural Hispanic BC survivors underutilize resources due to lack of knowledge about community resources, insufficient patient referrals for services, and language barriers. Financial challenges increase the likelihood of delays in seeking treatment, poor quality of life, and early death. This community-academic research partnership between the Kern County Cancer Foundation (KCCF) and San Diego State University (SDSU), collaborating with community stakeholders and key informants, aims to identify and document community assets to address these challenges and elicit resource mobilization strategies in Kern County, a rural and underserved region. Questions: 1. What types of assets are available in the community? 2. What are the best approaches to mobilize resources in the community? General methodology: First, we will conduct 3 focus groups (8 people in each group) with two groups of Hispanic BC survivors and family members (each group by language: English, Spanish) and one group of health care professionals from the local organizations/institutions and key informants (e.g., community leader). The total sample size will be 24. Second, based on the information obtained from the focus groups and internet (e.g., findhelp.org), we will create asset inventories and then create visual asset mapping. We will also discuss the strategies to mobilize resources in the community. Content analysis will be used to analyze the data. Innovation and potential impact: This pilot project is innovative in that first, as a community-based participatory research (CBPR) project, it maximizes participants’ voices and input of the community throughout the research process. Second, despite system issues, information on the systems level approach to improve access/mobilization of financial resources is limited. Hence, this proposed CBPR project will expand our knowledge about the tangible/intangible community assets, best approaches to mobilize them, and opportunities to build community capacity.
Additional file 6 of Needs for mobile and internet-based psychological intervention in patients with self-injury and suicide-related behaviors: a qualitative systematic review
Creators: name: Luo, Meiqi
name: Yue, Yuchuan
name: Du, Na
name: Xiao, Yu
name: Chen, Chunyan
name: Huan, Zongsu
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 6. The results of the GRADE-CERQual of the synthesized findings.
Identification of naturally occurring compounds as alternatives to radiation therapy for treatment of small cell lung cancer
Creators: name: Pingali, M. Shivapriya
name: Singh, Anirudh
name: Anand, Ananya Anurag
name: Gupta, Sachin Kumar
name: Sahoo, Amaresh Kumar
name: Varadwaj, Pritish Kumar
name: Samanta, Sintu Kumar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Radiation resistance is one of the major problems in the treatment of small cell lung cancer (SCLC). Most of these patients are given radiation as first-line treatment and it was observed that the initial response in these patients is very good. However, they show relapse in a few months which is also associated with resistance to treatment. Thus, targeting the mechanism by which these cells develop resistance could be an important strategy to improve the survival chances of these patients. From the RNA-Seq data analysis, it was identified that CHEK1 gene was overexpressed. Chk1 protein which is encoded by the CHEK1 gene is an important protein that is involved in radiation resistance in SCLC. It is known to favour the cells to deal with replicative stress. CHEK1 is the major cause for developing radiation resistance in SCLC. Thus, natural compounds that could also serve as potential inhibitors for Chk1 were explored. Accordingly; the compounds were screened based on ADME, docking and MM-GBSA scores. MD simulations were performed for the selected protein-ligand complexes and the results were compared to the co-crystallised ligand, 3-(indol-2-yl)indazole. The results showed that compound INC000033832986 could be a natural alternative to the commercial ligand for the prevention of SCLC. Communicated by Ramaswamy H. Sarma
OmtaSuppplDataR2 – Supplemental material for Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening
Creators: name: Wienand A. Omta
name: Heesbeen, Roy G. Van
name: Shen, Ian
name: Nobel, Jacob De
name: Robers, Desmond
name: Velden, Lieke M. Van Der
name: Medema, René H.
name: Siebes, Arno P. J. M.
name: Feelders, Ad J.
name: Brinkkemper, Sjaak
name: Klumperman, Judith S.
name: Spruit, Marco René
name: Brinkhuis, Matthieu J. S.
name: Egan, David A.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, OmtaSuppplDataR2 for Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening by Wienand A. Omta, Roy G. van Heesbeen, Ian Shen, Jacob de Nobel, Desmond Robers, Lieke M. van der Velden, René H. Medema, Arno P. J. M. Siebes, Ad J. Feelders, Sjaak Brinkkemper, Judith S. Klumperman, Marco René Spruit, Matthieu J. S. Brinkhuis and David A. Egan in SLAS Discovery
Couple_Identity_Clarity_Supplemental_Material_R2 - Who are “We”? Couple Identity Clarity and Romantic Relationship Commitment
Creators: name: Emery, Lydia F.
name: Gardner, Wendi L.
name: Carswell, Kathleen L.
name: Finkel, Eli J.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Couple_Identity_Clarity_Supplemental_Material_R2 for Who are “We”? Couple Identity Clarity and Romantic Relationship Commitment by Lydia F. Emery, Wendi L. Gardner, Kathleen L. Carswell and Eli J. Finkel in Personality and Social Psychology Bulletin
Assessing environmental & social factors influencing breast cancer prevention in Latina farmworkers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Breast cancer is an urgent public health issue that affects Latina farmworkers, particularly when examining deaths rates and stage of diagnosis. There are multiple factors in the development of cancer including mutations and family history, behavioral, occupational, and environmental factors. Latina farmworkers may be at higher risk of developing breast cancer due to their exposure to pesticides and various social factors such low socioeconomic status, non-English preference, and mistrust with providers, which have been associated with cancer. However, more information is needed to better understand Latina farmworkers’ exposure to various cancer-related chemicals and a deeper understanding of the various factors influencing their ability to engage in breast cancer screening. Here, we propose a study to measure the direct exposure to multiple chemicals linked to cancer along with their knowledge, attitudes, current facilitators, and barriers surrounding breast cancer screening and the strategies to address these barriers among Latina farmworkers in Imperial Valley, California. Our team will evaluate many environmental carcinogens utilizing new analytical tools and assess knowledge/attitudes surrounding breast cancer using surveys. In addition, we will conduct interviews on facilitators and barriers to breast screening among various participants, and probe on potential strategies for addressing those barriers. This study will provide initial evidence needed to develop interventions to reduce exposures linked to cancer among Latina farmworkers and to improve their access to breast cancer screening. The results of this study will support health equity within breast cancer prevention among a particularly marginalized population.
In-silico investigation of 4-nitro-N-1H-pyrazol-3-ylbenzamide towards its potential use against SARS-CoV-2: a DFT, molecular docking and molecular dynamics study
Creators: name: V., Niranjana S.
name: S., Chethan B.
name: Mahesha
name: N., Chethan Prathap K.
name: K., Hema M.
name: K., Lokanath N.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: In the present research work, we report the synthesis and characterization of novel pyrazole derivative obtained by the condensation reaction of 4-nitro benzaldehyde group with one equivalent of the 2-amino pyrazole yielding 4-nitro-N-1H-pyrazol-3-ylbenzamide with high yield. The two symmetry-independent molecules (molecule A and molecule B) differ about the central C-N bond, with the dihedral angles between the pyrazole ring system and the nitrobenzene ring being 13.90° and 18.64°, respectively. By optimizing the symmetry-independent dimer molecules, the rotational barrier between the conformers is found to be within the 2.5–5.5 kcal/mol range. QTAIM and RDG based NCI isosurface revealed the presence of strong N-H…N and C-H…O hydrogen bonds which stabilize the two independent centrosymmetric inversion-related dimers. Further, weak and short directional interactions such as C-H…N, H…H and C-H…π were also analyzed systematically using various topological parameters. The compound is found to adhere to the Lipinski’s rule of five and exhibit good pharmacokinetic properties. The results of molecular docking studies performed against SARS-CoV-2 virus main protease (PDB IDs: 6LU7, 6W9C and 6WQF) revealed that the compound showed better docking scores. Molecular docking studies verified the inhibition activity of the synthesized novel compound. Finally, the binding free energy and contributed energies were calculated using MM-GBSA method. The 6LU7-ligand complex showed highest binding free energy and among all other interactions, the contributions of the covalent binding and van der Waals energy are found to be significant. Communicated by Ramaswamy H. Sarma
An insight into the cytotoxic, antimicrobial, antioxidant, and biocontrol perspective of novel Iron(III) complexes of substituted benzimidazoles: Inhibition kinetics and molecular simulations
Creators: name: Roopashree, B.
name: Mahesh, B.
name: Ramu, Ramith
name: Rekha, N. D.
name: Manjula, S. N.
name: Preethi, G.
name: Gayathri, V.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Mononuclear complexes [FeCl3L2(OH2)] (L = L1, L2) were designed and synthesized by combining FeCl3 with 2-(3′-Aminophenylbenzimidazole) (L1) and 2-[(3′-N-Salicylidinephenyl)benzimidazole] (L2) and were characterized by physico-analytical strategies. The redox properties of the complexes were disclosed by the cyclic voltammetric method. Further, the interactions of complexes with proteins were studied by performing molecular docking engaging protein models of common cancer therapeutic targets to foresee their affinity to bind to these proteins. The complexes evidenced better protein-ligand docking (−8.4 and −9.0 kcal mol−1) and higher binding energies than their ligands. However, the L1 complex displayed improved binding free energy (−33.576 ± 1.01 kcal mol−1) compared to the other complexes and individual ligands. These compounds were screened for in vitro cytotoxic assays against triple-negative breast cancer cell lines (MDA-MB-468 cells), anti-inflammatory, antimicrobial, and antioxidant properties. The in vitro study complemented the in silico assay; therefore, these compounds may be a viable choice for expanding anticancer therapy. Additionally, the L2 showed better biocontrol activity owing to the enhanced growth of Trichoderma and inhibited the growth of Fusarium oxysporum. Communicated by Ramaswamy H. Sarma
Detect Signs of Early Life Exposures in Midlife to Prevent Breast Cancer Inequities
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Introduction. Many environmental chemicals could transmit breast cancer risk from mother to daughter during the mother’s pregnancy. Stress may magnify the consequences of exposures in the womb. Research Questions. 1) Are there patterns in our DNA in midlife (DNA methylation, DNAm, which impact how genes are regulated) that signify exposure to environmental chemicals in the womb? 2) Do DNAm signals reflect changes in biological pathways that lead to breast cancer? 3) Do Black women have more or different exposures in the womb and are the consequences worse because of neighborhood stressors, experiences of discrimination, and resulting cumulative life stress? 3) Are there environmental chemical exposures in midlife that magnify effects of exposures in the womb and are these more intense in Black women? Research Methods. High-resolution mass spectrometry (HRM) is a new technology to measure thousands of chemicals in blood. So, it is now possible to find chemicals in mothers’ pregnancy blood that link to daughters’ breast cancer that no one suspected before. Through other funding, we are completing HRM in mothers’ pregnancy blood and in daughters’ midlife blood in a 2-generation study of Alzheimer’s disease in the Child Health and Development Studies pregnancy cohort. Here we propose to add measures of DNAm in daughters’ blood samples that were previously collected in midlife. Then we will link exposures in the womb to our existing data on neighborhood stressors, age at menarche, obesity, lifetime stress and to the new DNAm measures. The study sample has an equal number of Black and white women creating a rare opportunity for a two-generation study that includes existing measures of exposures in the womb and midlife combined with information on neighborhood and cumulative lifetime stress. Innovation and Impact. We will find new environmental chemicals that could transmit breast cancer risk from mother to daughter during the mother’s pregnancy, learn whether these are higher in Black women, whether neighborhood, lifetime stress and exposures in midlife magnify risk from exposures in the womb. This new evidence will support ways to intervene early in life to reduce inequities over generations and may reveal some midlife strategies. We will provide this information to women and decision makers to reduce inequities in risk of fatal breast cancer for Black women.
Parental and grandparental exposome and breast cancer biomarkers in daughters and granddaughters
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: We have shown that the pesticide DDT in the grandmothers’ blood during pregnancy correlates with breast cancer in grandmothers and their daughters, obesity in daughters and granddaughters and age at menarche in granddaughters in a 60-year follow-up of the Child Health and Development Studies (CHDS). We propose to expand this work to screen thousands of chemicals in grandmothers and grandfathers’ blood collected at the time of pregnancy for correlations with a new breast cancer biomarker in daughters and granddaughters (DNA methylation, DNAm, which controls how genes function). Research Questions 1) Which DNAm patterns in daughters and granddaughters correlate with their age at menarche and obesity? 2) Do these informative DNAm patterns overlap in daughters and granddaughters? 3) Are these or other DNAm patterns correlated with grandmother and/or grandfather exposures? 4) Are grandparents’ exposures different or greater in families of Black women and linked to DNAm patterns for aggressive breast cancer? Methods Through other funding, we measured thousands of environmental chemicals in grandfathers’ and grandmothers’ blood with the new technology, high-resolution mass spectrometry (HRM) in the 3-Generations Breast Cancer study, a subset of the CHDS. We will add measures of DNAm in 100 daughter-granddaughter pairs (200 women) to discover links between grandmothers’ and grandfathers’ exposures to their daughters’ and granddaughters’ age at menarche, obesity and DNAm. Innovation and Impact We will find new environmental chemicals that correlate with breast cancer risk across 3 generations. The new chemical risk factors we discover will be relevant to chemicals currently in our environment. Very few of the thousands of chemicals present in the 1960’s have been banned and some are now accumulating in our bodies. Findings about grandfathers will be unique and will inform prevention messages for young men on how fathers contribute to breast cancer risk. Novel DNAm biomarkers will expand scientific knowledge on how transfer of risk over generations happens and will support prevention efforts that reach young people. Results specific to Black women will result in relevant prevention messages for Black women. Findings will lead to new opportunities for breast cancer prevention via policy, individual choices, and potentially, via repair of damaged DNAm.
Additional file 2 of Virome analysis of Desmodus rotundus tissue samples from the Amazon region
Creators: name: Albuquerque, Nádia K.
name: Silva, Sandro P.
name: Aragão, Carine F.
name: Cunha, Tânia Cristina A. S.
name: Paiva, Francisco A. S.
name: Coelho, Taciana F. S. B.
name: Cruz, Ana Cecília R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 2.
Supplemental material for Outcomes of scapulothoracic fusion in facioscapulohumeral muscular dystrophy: A systematic review
Creators: name: Dorsa Kord
name: Liu, Eva
name: Horner, Nolan S
name: Athwal, George S
name: Khan, Moin
name: Alolabi, Bashar
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material for Outcomes of scapulothoracic fusion in facioscapulohumeral muscular dystrophy: A systematic review by Dorsa Kord, Eva Liu, Nolan S Horner, George S Athwal, Moin Khan and Bashar Alolabi in Shoulder & Elbow
Supplemental Material, Appendix - The Impact of Variable Pricing, Dynamic Pricing, and Sponsored Secondary Markets in Major League Baseball
Creators: name: Courty, Pascal
name: Davey, Luke
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: Economics
subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental Material, Appendix for The Impact of Variable Pricing, Dynamic Pricing, and Sponsored Secondary Markets in Major League Baseball by Pascal Courty and Luke Davey in Journal of Sports Economics
Wristbands, biomonitoring, and metabolomics to detect nurses’ chemical exposure and early effects
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The proposed Women Workers Biomonitoring Collaborative study -Wristbands, biomonitoring, and metabolomics to detect nurses’ chemical exposure and early effects- expands our investigation of breast cancer-relevant workplace exposures and demonstrates new approaches in exposomics and metabolomics. These approaches look for novel exposures in nurses very broadly without deciding in advance which chemicals to target. The project responds to nurse collaborators’ concerns about hazardous work exposures. We propose to measure nurses’ exposure to disinfectants, drugs, PFAS, and other breast cancer-relevant chemicals; to integrate biomonitoring and workplace air monitoring through a silicone wristband; and to discover associations between exposures and early biological effects that we measure in their blood. We have four specific aims: Aim 1: Collect blood, urine, and silicone wristband passive air monitors from 60 nurses and 40 office workers. Measure chemicals of interest using targeted and non-targeted approaches. Aims 2 and 3: Compare exposures between nurses and office workers and identify correlated exposures between wristbands and blood. Aim 4: Identify changes in blood that are associated with chemical exposures and determine affected biological pathways relevant to breast cancer. We hypothesize that we will detect drugs, disinfectants, PFAS and other breast cancer-relevant exposures in wristbands or blood, that nurses will have some unique exposures, and that some chemical exposures will be associated with biological changes in blood. This project advances a critical path to breast cancer prevention by applying new methods for measuring exposures to breast cancer-relevant chemicals and associated early biological changes. Measuring these associations provides insights into biological pathways for breast cancer-relevant chemicals and supports efforts to reduce exposures. By studying nurses, we may uncover potential sources of higher breast cancer risk in this group. Our partnership of researchers, advocates, and nurses ensures our questions are relevant to what exposed communities care about and produces the science needed to strengthen public health protections. It is the basis for translating our findings into policy changes that reduce exposures and associated risks. The work enhances the WWBC sample archive, creating a valuable resource for further study.
Computational studies to explore inhibitors against the cyclin-dependent kinase 12/13 enzyme: an insilco pharmacophore modeling, molecular docking and dynamics approach
Creators: name: Ghosh, Amar
name: Jha, Prakash C.
name: Manhas, Anu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Cancer is enlisted among the deadliest disease all over the world. The cyclin-dependent kinases 12 and 13 have been identified as cell cycle regulators. They conduct transcription and co-transcriptional processes by phosphorylating the C-terminal of RNA polymerase-II. Inhibition of CDK12 and 13 selectively presents a novel strategy to treat triple-negative breast cancer, but dual inhibitors are still lacking. Here, we report the screening of the natural product compound class against the dual CDK12/13 enzyme by employing various in silico methods. Complexes of CDK12 enzymes are used to form common feature pharmacophore models, whereas we perform receptor-based pharmacophore modelling on CDK13 enzyme owing to the availability of a single PDB. On conducting screening over the representative pharmacophores, the common drug-like screened natural products were shortlisted for conducting molecular docking studies. After molecular docking calculations, the candidates that showed crucial interaction with CDK12 and CDK13 enzymes were shortlisted for simulation studies. Five common docked candidates were selected for molecular dynamics simulations and free energy calculations. Based on the cut-off criteria of free energy calculations, one common hit was selected as the dual CDK12/13 inhibitor. The outcome concluded that the hit with ID CNP0386383 possesses drug-like properties, displays crucial interaction in the binding pocket, and shows stable dynamic behaviour and higher binding energy than the experimentally reported inhibitor of both CDK12 and CDK13 enzymes. Communicated by Ramaswamy H. Sarma
Promotora Training: Reducing Impact of Environmental Toxins on Breast Cancer & Reproductive Health
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: We propose to study the impact on friends, family, and other community members from being educated by Promotoras, (lay health educators), related to the impact of dangerous chemicals on breast cancer and reproductive health. The study will examine the knowledge, behaviors, and practices of Latinas who are educated by Promotoras. Through peer-to-peer learning, Latinas will learn about actions that individuals, families, and communities can take to lower their exposure to toxins. The main focus will be on the behaviors that can be changed as a result of this training as the Latinas within this study population cannot control all environmental exposures they may be in contact with in their workplace or at home. Latinas will have a chance to use a text-based app program that will provide additional educational materials and resources, apart from what they learned from the Promotoras. We hope to include 20 promotoras who each deliver a training to two groups of 8-10 Latinas within their communities. Therefore, we believe a total of 180-200 participants will be included in the study. We will discover the impact of the promotora training program in three main areas: if the Latinas trained in the program learn new information about hidden hazards and how to reduce and eliminate their exposures, if Latinas feel confident in adjusting their behaviors to lessen their contact with dangerous chemicals, and if indeed they change any behaviors or actions to lower their contact with environmental toxins. We will give the Latinas a survey before and after they are educated by the Promotoras to collect information about what they knew before learning from the Promotoras, as well as what they found out about because of the program. We will also ask survey questions about their backgrounds, so that we know information about who the Latinas are that received the educational training from Promotoras. Furthermore, three weeks and three months after the program, we will ask the Latinas more questions about any changes they made in lowering their contact to environmental hazards.
Women HEALERS Reducing Toxic Environmental Exposures and Preventing Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Bayview-Hunters Point (BVHP) is a historically African American community, that due largely to systemic racist redline practices, has a high concentration of polluting sources including a highly contaminated Superfund site, the Hunters Point Navy Shipyard, with known exposures to radiation and other toxic chemicals. Chemical contaminants detected throughout the neighborhood and deemed carcinogenic by the International Agency for Research on Cancer are known endocrine-disrupting chemicals (EDCs), including benzene, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls, some of which have been detected in groundwater. Exposure to endocrine disrupting pollutants has been found to increase the risk of breast cancer. As EDCs are persistent in the environment and bio-accumulative, it is important to assess the longer-term impacts of EDC exposures across generations. In San Francisco, Black/African American women experience the greatest disparities in breast cancer-related outcomes. Compared to other neighborhoods in San Francisco, women from BVHP were more likely to be diagnosed with more aggressive breast tumors with a faster growth rate, and overall higher breast cancer mortality rates. BVHP residents have the shortest life expectancy in the San Francisco area, well below California's average life expectancy of 82 years. A decades-long history of systemic racism and multiple environmental contaminants, combined with ineffective assessments, poor clean-up, and untrustworthy behavior by institutions, has contributed to BVHP community concerns about the potential link between exposure to toxic contaminants and cancers and frustration over a lack of reliable scientific information about risk, accountability and transparency of government and industry polluters to clean up known toxins, and the need for greater community engagement and oversight. The goals of this pilot project are to address the organizational and research issues necessary for creating an intervention strategy that would provide women living in the BVHP with the training and support – the Health Equity Advocates and Leaders in Environmental Research and Science (HEALERS) program - to educate and activate the community about the prevention of harmful environmental exposures and advocate for policies that protect health and decrease incidence of breast cancer.
Additional file 2 of Uncovering the mechanisms underlying pear leaf apoplast protein-mediated resistance against Colletotrichum fructicola through transcriptome and proteome profiling
Creators: name: Han, Chenyang
name: Su, Zhiyuan
name: Zhao, Yancun
name: Li, Chaohui
name: Guo, Baodian
name: Wang, Qi
name: Liu, Fengquan
name: Zhang, Shaoling
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 2: Figure S1. The relative expression levels of several apoplast proteins genes in C. fructicola infected plants and healthy plants. Bar values represent the means SEM of three biological replicates with three technical replicates. * indicate significant differences, * p<0.05, ** p<0.01. Figure S2. Phylogeny and conserved motifs of GH17 gene family genes in pear. The conserved motifs were analyzed by the MEME tool (http://memesuite.org/) using the default settings. Figure S3. Predicted protein structures of PbrGlu1 and AT1G32860.1. a The predicted Pfam domain of PbrGlu1 and AT1G32860.1. b Schematic representation of PbrGlu1 and AT1G32860.1 model based on the predicted protein structure from UniProt ( https://www.uniprot.org/ ).
Defining the Cellular Origin of BRCA1-associated Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: About 25,000 women are diagnosed with breast cancer each year in CA. 10% are directly linked to a family history of breast cancer with inherited gene mutations. BRCA1 and BRCA2 account for at least half of inherited breast cancer. Mutations on BRCA1 predispose women to triple-negative breast cancer (TNBC), an aggressive breast cancer subtype with a 12% 5-year survival rate when TNBC spreads to other parts of the body. Prophylactic mastectomy while effective to reduce breast cancer risk in BRCA1/2 patients, poses significant psychological side effects and impairs the life quality of BRCA1 carriers. A noninvasive method is urgently needed for breast cancer early detection and/or prevention in BRCA1 carriers. An essential step is to understand how the normal breast epithelial cells become pre-neoplastic lesions and later tumor cells in BRCA1 patients. Human breast epithelium is organized as a bilayer with a basal layer of myoepithelial cells and luminal epithelial layer surrounding the mammary lumen. Early work demonstrated that the long-lived luminal epithelial cells or luminal progenitors are the cellular origin of BRCA1-associated breast cancer. However, only a small subset of luminal progenitors responds to BRCA1 loss and become aberrantly differentiated. The overarching goal of this proposal is to define the cellular origin of BRCA1 breast cancer and to dissect the mechanism(s) to control the transition from normal breast epithelial cells to pre-neoplastic lesions and tumor cells. Our preliminary data thus far identified a novel marker in the BRCA1-deficient luminal progenitors. We hypothesize that this unique luminal progenitor cells are the cellular origin of BRCA1 breast cancer. To test this hypothesis, we will use a mouse model to specifically deplete BRCA1 in aberrant luminal progenitors while simultaneously labeling the cells with red fluorescent protein to follow the BRCA1 deficient cells. Using the single cell gene expression profile technology, we will track the development of the red normal cells to red pre-neoplastic lesions and red tumor cells. This analysis will provide key insights into the mechanism(s) of pre-neoplastic lesion formation, one of earliest stage of breast cancer. This work, if successfully completed will provide novel biomarkers for early detection and/or prevention such work can directly benefit BRCA1-mutated patients.