cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring frailty: muscle strength, functional capacity, activities of daily living and cognition in adult congenital heart disease
Creators: name: Topcuoglu, Ceyhun
name: Yagli, Naciye Vardar
name: Aykan, Hayrettin Hakan
name: Ertugrul, Ilker
name: Karagoz, Tevfik
name: Saglam, Melda
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Developmental Biology
subject: Mental Health

description: The study aimed to assess frailty in adults with congenital heart disease (ACHD) and to compare muscle strength, functional capacity, activities of daily living (ADL), and cognition between frail and non-frail ACHD patients. A cross-sectional study design was used. Sixty people with ACHD aged between 18 and 45 years were included. Frailty was determined according to the Fried criteria. Peripheral muscle strength was assessed with a digital dynamometer, functional capacity with the 6-min walk test (6MWT), ADL with the Glittre ADL test, and cognition with the Montreal Cognitive Assessment (MoCA) test. Frailty was seen in 38.33% (frail = 23 and non-frail = 37) of the participants. In the frail patients, dominant knee extensor strength (p = 0.002), shoulder abductor strength (p = 0.005), 6MWT distance (p = 0.021), and MoCA score (p = 0.005) were significantly lower than those in the non-frail patients. Glittre ADL test (p = 0.002) was significantly higher in the frail patients. Muscle strength, functional capacity, ADL, functional mobility, and cognition were lower in the frail participants with ACHD. Early assessment of frailty in ACHD and planning individualized exercise training programs for frail individuals may be a strategy to reduce the impact of frailty on adverse clinical outcomes. We found that muscle strength, functional capacity, ADL, functional mobility, physical activity, and cognition were lower in the frail ACHD patients than in the non-frail ones.Early assessment of frailty in individuals with ACHD is important for determining health status.Planning individualized exercise training programs for individuals with ACHD may be a strategy to reduce the impact of frailty on adverse clinical outcomes. We found that muscle strength, functional capacity, ADL, functional mobility, physical activity, and cognition were lower in the frail ACHD patients than in the non-frail ones. Early assessment of frailty in individuals with ACHD is important for determining health status. Planning individualized exercise training programs for individuals with ACHD may be a strategy to reduce the impact of frailty on adverse clinical outcomes.
Die ältestbandkeramische Grabenanlage in Eitzum, Ldkr. Wolfenbüttel. Überlegungen zur Verfüllung und Interpretation von Befunden
Creators: name: Stäuble, Harald
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
title: ESLO1: entretien 166_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target
Creators: name: Arun, K. G.
name: Sharanya, C. S
name: Abhithaj, J.
name: Francis, Dileep
name: Sadasivan, C.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Since its first report in December 2019 from China, the COVID-19 pandemic caused by the beta-coronavirus SARS-CoV-2 has spread at an alarming pace infecting about 5.59 million, and claiming the lives of more than 0.35 million individuals across the globe. The lack of a clinically approved vaccine or drug remains the biggest bottleneck in combating the pandemic. Drug repurposing can expedite the process of drug development by identifying known drugs which are effective against SARS-CoV-2. The SARS-CoV-2 main protease is a promising drug target due to its indispensable role in viral multiplication inside the host. In the present study an E-pharmacophore hypothesis was generated using a crystal structure of the viral protease in complex with an imidazole carbaximide inhibitor. Drugs available in the superDRUG2 database were used to identify candidate drugs for repurposing. The hits obtained from the pharmacophore based screening were further screened using a structure based approach involving molecular docking at different precisions. The binding energies of the most promising compounds were estimated using MM-GBSA. The stability of the interactions between the selected drugs and the target were further explored using molecular dynamics simulation at 100 ns. The results showed that the drugs Binifibrate and Bamifylline bind strongly to the enzyme active site and hence they can be repurposed against SARS-CoV-2. However, U.S Food and Drug Administration have withdrawn Binifibrate from the market as it was having some adverse health effects on patients. Communicated by Ramaswamy H. Sarma
Volcanogenic Dark Matter and Mass Extinctions
Creators: name: Abbas, Samar
name: Abbas, Afsar
Publisher: name: arXiv
Year: 1996
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Biological Physics (physics.bio-ph)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The passage of the Earth through dense clumps of dark matter, the presence of which are predicted by certain cosmologies, would produce large quantities of heat in the interior of this planet through the capture and subsequent annihilation of dark matter particles. This heat can cause large-scale volcanism which could in turn have caused the extinction of the dinosaurs and other mass extinctions. The periodicity of such volcanic outbursts agrees with the frequency of palaeontological mass extinctions as well as the observed periodicity in the occurrence of the largest flood basalt provinces on the globe.
description: 6 pages in Latex file
Taggle: Combining Overview and Details in Tabular Data Visualizations
Creators: name: Furmanova, Katarina
name: Gratzl, Samuel
name: Stitz, Holger
name: Zichner, Thomas
name: Jaresova, Miroslava
name: Lex, Alexander
name: Streit, Marc
Publisher: name: arXiv
Year: 2017
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Most tabular data visualization techniques focus on overviews, yet many practical analysis tasks are concerned with investigating individual items of interest. At the same time, relating an item to the rest of a potentially large table is important. In this work we present Taggle, a tabular visualization technique for exploring and presenting large and complex tables. Taggle takes an item-centric, spreadsheet-like approach, visualizing each row in the source data individually using visual encodings for the cells. At the same time, Taggle introduces data-driven aggregation of data subsets. The aggregation strategy is complemented by interaction methods tailored to answer specific analysis questions, such as sorting based on multiple columns and rich data selection and filtering capabilities. We demonstrate Taggle using a case study conducted by a domain expert on complex genomics data analysis for the purpose of drug discovery.
Befestigte Siedlungen der Bernburger Kultur-Typen und Verbreitung
Creators: name: Müller, Detlef W.
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
Brzesc Kujawski. Beispiel einer natürlich befestigten Siedlung der Lengyel-Kultur in Kujawy
Creators: name: Grygiel, Ryszard
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
title: ESLO1: interview de personnalité 414_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
The role of three-body collisions in phi-meson production processes near threshold
Creators: name: Barz, H. W.
name: Kampfer, B.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The amplitude of subthreshold phi-meson production is calculated using dominant tree-level diagrams for three-body collisions. It is shown that the production can overwhelmingly be described by two-step processes. The effect of the genuine three-body contribution (i.e. the contribution which cannot be factorized) is discussed. The production rate of phi-mesons is presented for proton induced reactions on carbon.
description: 19 pages
Efficient stereoselective synthesis of 5a-carba-α-L-mannopyranose starting from naturally abundant (−)-shikimic acid
Creators: name: Zhu, Xin-Liang
name: Liang, Xian-Ru
name: Luo, Yong-Qiang
name: Wang, Lei
name: Shi, Xiao-Xin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: In this article, an efficient and practical stereoselective synthesis of 5a-carba-α-L-mannopyranose from naturally abundant (−)-shikimic acid is discussed. 5a-Carba-α-L-mannopyranose was synthesized via 11 steps in 43% overall yield starting from (−)-shikimic acid. The overall yield of the total synthesis is high, the reaction conditions for all steps are mild, the operation procedures of all steps are simple, and the reagents used in all steps are cheap and readily available.
Ethnomedicines of Indian origin for combating COVID-19 infection by hampering the viral replication: using structure-based drug discovery approach
Creators: name: Lakshmi, Selvaraj Alagu
name: Shafreen, Raja Mohamed Beema
name: Priya, Arumugam
name: Shunmugiah, Karutha Pandian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology

description: In the present study, we have explored the interaction of the active components from 10 different medicinal plants of Indian origin that are commonly used for treating cold and respiratory-related disorders, through molecular docking analysis. In the current scenario, COVID-19 patients experience severe respiratory syndromes, hence it is envisaged from our study that these traditional medicines are very likely to provide a favourable effect on COVID-19 infections. The active ingredients identified from these natural products are previously reported for antiviral activities against large group of viruses. Totally 47 bioactives identified from the medicinal plants were investigated against the structural targets of SARS-CoV-2 (Mpro and spike protein) and human ACE2 receptor. The top leads were identified based on interaction energies, number of hydrogen bond and other parameters that explain their potency to inhibit SARS-CoV-2. The bioactive ligands such as Cucurbitacin E, Orientin, Bis-andrographolide, Cucurbitacin B, Isocucurbitacin B, Vitexin, Berberine, Bryonolic acid, Piperine and Magnoflorine targeted the hotspot residues of SARS-CoV-2 main protease. In fact, this protease enzyme has an essential role in mediating the viral replication and therefore compounds targeting this key enzyme are expected to block the viral replication and transcription. The top scoring conformations identified through docking analysis were further demonstrated with molecular dynamics simulation. Besides, the stability of the conformation was studied in detail by investigating the binding free energy using MM-PBSA method. Overall, the study emphasized that the proposed hit Cucurbitacin E and orientin could serve as a promising scaffold for developing anti-COVID-19 drug. Communicated by Ramaswamy H. Sarma
title: ESLO1: interview de personnalité 409_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Optical, near-infrared and hard X-ray observations of SAXJ1353.9+1820: a red quasar
Creators: name: Vignali, C.
name: Mignoli, M.
name: Comastri, A.
name: Maiolino, R.
name: Fiore, F.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of a follow-up ASCA observation and multicolour optical and near-infrared photometry carried out at the 3.5-m Italian National Telescope Galileo of SAXJ1353.9+1820. This object, serendipitously discovered by BeppoSAX in the 5-10 keV band, has been spectroscopically identified as a red quasar at z=0.217. The combined X-ray and optical-infrared data reveal the presence of a moderately luminous X-ray source (~ 10^{44} erg s^{-1}) obscured by a column density of the order of 10^{22} cm^{-2} in a otherwise optically passive early-type galaxy. The implications for the nature of red quasars and their possible contribution to the hard X-ray background are briefly outlined.
description: 5 pages, LateX, 4 figures (included), mn-1.4.sty and psfig.sty macros. Accepted by MNRAS
François-Louis de la Grange
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: Officier de justice d'Ancien Régime

description: Source: http://www.sudoc.fr/080675700
description: Coverage: Parlement de Flandre
Identification of bioactive compounds from Glycyrrhiza glabra as possible inhibitor of SARS-CoV-2 spike glycoprotein and non-structural protein-15: a pharmacoinformatics study
Creators: name: Sinha, Saurabh K.
name: Prasad, Satyendra K.
name: Islam, Md Ataul
name: Gurav, Shailendra S.
name: Patil, Rajesh B.
name: AlFaris, Nora Abdullah
name: Aldayel, Tahany Saleh
name: AlKehayez, Nora M.
name: Wabaidur, Saikh Mohammad
name: Shakya, Anshul
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 60506 Virology

description: At present, the world is facing a pandemic named as COVID-19, caused by SARS-CoV-2. Traditional Chinese medicine has recommended the use of liquorice (Glycyrrhiza species) in the treatment of infections caused by SARS-CoV-2. Therefore, the present investigation was carried out to identify the active molecule from the liquorice against different protein targets of COVID-19 using an in-silico approach. The molecular docking simulation study of 20 compounds along with two standard antiviral drugs (Lopinavir and Rivabirin) was carried out with the help of Autodock vina software using two protein targets from COVID-19 i.e. spike glycoprotein (PDB ID: 6VSB) and Non-structural Protein-15 (Nsp15) endoribonuclease (PDB ID: 6W01). From the observed binding energy and the binding interactions, glyasperin A showed high affinity towards Nsp15 endoribonuclease with uridine specificity, while glycyrrhizic acid was found to be best suited for the binding pocket of spike glycoprotein and also prohibited the entry of the virus into the host cell. Further, the dynamic behavior of the best-docked molecules inside the spike glycoprotein and Nsp15 endoribonuclease were explored through all-atoms molecular dynamics (MD) simulation study. Several parameters from the MD simulation have substantiated the stability of protein-ligand stability. The binding free energy of both glyasperin A and glycyrrhizic acid was calculated from the entire MD simulation trajectory through the MM-PBSA approach and found to high binding affinity towards the respective protein receptor cavity. Thus, glyasperin A and glycyrrhizic acid could be considered as the best molecule from liquorice, which could find useful against COVID-19. Communicated by Ramaswamy H. Sarma
Transition Strength Sums and Quantum Chaos in Shell Model States
Creators: name: Kota, V. K. B.
name: Sahu, R.
name: Kar, K.
name: Gomez, J. M. G.
name: Retamosa, J.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: For the embedded Gaussian orthogonal ensemble (EGOE) of random matrices, the strength sums generated by a transition operator acting on an eigenstate vary with the excitation energy as the ratio of two Gaussians. This general result is compared to exact shell model calculations, with realistic interactions, of spherical orbit occupancies and Gamow-Teller strength sums in some $(ds)$ and $(fp)$ shell examples. In order to confirm that EGOE operates in the chaotic domain of the shell model spectrum, calculations are carried out using two different interpolating hamiltonians generating order-chaos transitions. Good agreement is obtained in the chaotic domain of the spectrum, and strong deviations are observed as nuclear motion approaches a regular regime (transition strength sums appear to follow the Dyson's $Δ_3$ statistic). More importantly, they shed new light on the newly emerging understanding that in the chaotic domain of isolated finite interacting many particle systems smoothed densities (they include strength functions) define the statistical description of these systems and these densities follow from embedded random matrix ensembles; some EGOE calculations to this end are presented.
description: 13 pages, ps-file, 5 figures; talk delivered by V.K.B. Kota at National seminar on Nuclear Physics, July 26-29, 1999, Institute of Physics, Bhubaneswar, India
Birth of magnetized low-mass protostars and circumstellar disks
Creators: name: Ahmad, Adnan Ali
name: González, Matthias
name: Hennebelle, Patrick
name: Lebreuilly, Ugo
name: Commerçon, Benoît
Publisher: name: arXiv
Year: 2025
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Although protostars and disks are often studied separately owing to numerical and observational challenges, breakthroughs in recent years have highlighted the need to study both objects in concert. The role of magnetic fields in this regard must be investigated. We aim to describe the birth of the protostar and that of its disk, as well as their early joint evolution following the second collapse. We wish to study the structure of the nascent star-disk system, while focusing on the innermost sub-AU region. We carry out high resolution 3D RMHD simulations, describing the collapse of dense cloud cores to stellar densities. The calculations reach $\approx 2.3$ yr after protostellar birth. Our simulations are also compared to their hydro counterpart to better isolate the role of magnetic fields. When accounting for ambipolar diffusion, the efficiency of magnetic braking is drastically reduced and the nascent protostar reaches breakup velocity, thus forming a rotationally supported disk. The diffusion of the magnetic field also allows for the implantation of a $\sim \mathrm{kG}$ field in the protostar, which is thereafter maintained. The magnetic field is mainly toroidal in the star-disk system, although a notable vertical component threads it. We also show that the nascent disk is prone to the MRI, although our resolution is inadequate to capture the mechanism. We note a sensitivity of the disk's properties with regards to the angular momentum inherited prior to the second collapse, as well as the magnetic field strength. These calculations carry multiple implications on several issues in stellar formation theory, and offer perspectives for future modeling of the system. Should the fossil field hypothesis to explain the origins of magnetic fields in young stellar objects hold, we show that a $\sim \mathrm{kG}$ field strength may be implanted and maintained in the protostar at birth.
description: 22 pages, 14 figures. Accepted for publication in A&A
Archäologische Untersuchungen am neolithischen Verteidigungswerk bei Slonowice, Woj. Kielce, in den Jahren 1979-1988. 2. Vorbericht
Creators: name: Tunia, Krzysztof
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
Remdesivir (GS-5734) as a therapeutic option of 2019-nCOV main protease – in silico approach
Creators: name: Naik, Vankudavath Raju
name: Munikumar, Manne
name: Ramakrishna, Ungarala
name: Srujana, Medithi
name: Goudar, Giridhar
name: Naresh, Pittla
name: Kumar, Boiroju Naveen
name: Hemalatha, Rajkumar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: 2019 – Novel Coronavirus (2019-nCOV), enclosed large genome positive-sense RNA virus characterized by crown-like spikes that protrude from their surface, and have a distinctive replication strategy. The 2019-nCOV belongs to the Coronaviridae family, principally consists of virulent pathogens showing zoonotic property, has emerged as a pandemic outbreak with high mortality and high morbidity rate around the globe and no therapeutic vaccine or drugs against 2019-nCoV are discovered till now. In this study, in silico methods and algorithms were used for sequence, structure analysis and molecular docking on Mpro of 2019-nCOV. The co-crystal structure of 2019-nCOV protease, 6LU7 have ∼99% identity with SARS-CoV protease. The 6LU7 residues, Cys145 and His164 are playing a significant role in replication and are essential for the survival of 2019-nCOV. Alongside, 2019-nCOV Mpro sequence is non-homologous to human host-pathogen. Complete genome sequence analysis, structural and molecular docking results revealed that Remdesivir is having a better binding affinity with -8.2 kcal/mol than the rest of protease inhibitors, and peptide. Remdesivir is strongly forming h-bonds with crucial Mpro residues, Cys145, and His164. Further, MD simulation analysis also confirmed, that these residues are forming H-bond with Remdesivir during 100 ns simulations run and found stable (∼99%) by RMSD and RMSF. Thus, present in silico study at molecular approaches suggest that, Remdesivir is a potent therapeutic inhibitor against 2019-nCoV. Communicated by Ramaswamy H. Sarma
Sandomierz - Wzgórze Zawichojskie. Beispiel einer neolithischen befestigten Anlage in Südostpolen
Creators: name: Kowalewska-Marszalek, Hanna
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
Geometric Gaussianity and Non-Gaussianity in the Cosmic Microwave Background
Creators: name: Inoue, Kaiki Taro
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: In this paper, Gaussianity of eigenmodes and non-Gaussianity in the Cosmic Microwave Background (CMB) temperature fluctuations in two smallest compact hyperbolic (CH) models are investigated. First, it is numerically found that the expansion coefficients of low-lying eigenmodes on the two CH manifolds behave as if they are Gaussian random numbers at almost all the places. Next, non-Gaussianity of the temperature fluctuations in the (l,m) space in these models is studied. Assuming that the initial fluctuations are Gaussian, the real expansion coefficients b_{l m} of the temperature fluctuations in the sky are found to be distinctively non-Gaussian. In particular, the cosmic variances are found to be much larger than that for Gaussian models. On the other hand, the anisotropic structure is vastly erased if one averages the fluctuations at a number of different observing points because of the Gaussian pseudo-randomness of the eigenmodes. Thus the dominant contribution to the two-point correlation functions comes from the isotropic terms described by the angular power spectra C_l. Finally, topological quantities: the total length and the genus of isotemperature contours are investigated. The variances of total length and genus at high and low threshold levels are found to be considerably larger than that of Gaussian models while the means almost agree with them.
description: 22 pages, 18 figures (eps files). Typos corrected
title: ESLO1: interview de personnalité 423_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Dynamic and Quasistatic Trajectories in Quasifission Reactions and Particle Emission
Creators: name: Aleshin, V. P.
name: Centelles, M.
name: Viñas, X.
name: Nicolis, N. G.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We show that the quasifission paths predicted by the one-body dissipation dynamics, in the slowest phase of a binary reaction, follow a quasistatic path, which represents a sequence of states of thermal equilibrium at a fixed value of the deformation coordinate. This establishes the use of the statistical particle-evaporation model in the case of dynamical time-evolving systems. Pre- and post-scission multiplicities of neutrons and total multiplicities of protons and alpha particles in fission reactions of 63Cu+92Mo, 60Ni+100Mo, 63Cu+100Mo at 10 MeV/u and 20Ne+144,148,154Sm at 20 MeV/u are reproduced reasonably well with statistical model calculations performed along dynamic trajectories whose slow stage (from the most compact configuration up to the point where the neck starts to develop) lasts some 35x10^{-21} s.
description: 29 pages, 9 figures
Neolithische Befestigungen und die Einfriedung von Bronocice
Creators: name: Milisauskas, Sarunas
name: Kruk, Janusz
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
Mineralogical characteristics of continental shale: a case study in Yan-Chang Formation, Ordos Basin
Creators: name: H. Deng
name: X. Xie
name: K. Chen
name: C. Vij
name: Y. Pang
name: H. A. Li
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: The Chang 7 Member of the Yan-Chang Formation (Yan-Chang #7 Member), which is located in the central south of the Ordos Basin (China), is assessed for its potential as a shale gas resource. The characteristics and spatial variability of mineral components in this continental shale formation play a crucial role in evaluating and characterising the shale reservoirs. We collected 64 shale core samples from 30 representative sampling sites located in the central south of the Ordos Basin using X-ray diffraction and field emission scanning electron microscopy to study the mineral compositions, vertical/planar variations of minerals, and the major controlling factors that result in such variations. Based on the relative fractions of the dominant minerals, the shale rocks can be classified into four categories: quartz-rich (type #1), illite/chlorite-rich (type #2), illite–smectite mixed-layer-rich (type #3) and feldspar-rich (type #4). In general, type #1 is mainly located in the northwest of the study area, type #4 is mainly located in the south of the study area, and types #2 and #3 are sandwiched between types #1 and #4. In the centre of the basin, the illite content increases with burial depth and the conversion from smectite to illite, which is experimentally confirmed in this study, enhances the surface porosity of shale. The major factors influencing the properties and spatial variability of the mineral components include sedimentary environment, provenance and diagenesis. Compared with marine shales in China (e.g. Longmaxi marine shales), the Yan-Chang #7 Member continental shale has a higher clay content, but lower calcite, dolomite and pyrite contents. The brittleness indexes of type #1 shale in Wuqi and its surrounding areas are marginally higher than that of Longmaxi marine shales, which makes the type #1 shale in the Wuqi and its surrounding areas slightly easier to fracture than the Longmaxi marine shales.
Collapsing cavities and converging shocks in non-ideal materials
Creators: name: Boyd, Zachary M.
name: Schmidt, Emma M.
name: Ramsey, Scott D.
name: Baty, Roy S.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: As modern hydrodynamic codes increase in sophistication, the availability of realistic test problems becomes increasingly important. In gas dynamics, one common unrealistic aspect of most test problems is the ideal gas assumption, which is unsuited to many real applications, especially those involving high pressure and speed metal deformation. Our work considers the collapsing cavity and converging shock test problems, showing to what extent the ideal gas assumption can be removed from their specification. It is found that while most materials simply do not admit simple (i.e. scaling) solutions in this context, there are infinite-dimensional families of materials which do admit such solutions. We characterize such materials, derive the appropriate ordinary differential equations, and analyze the associated nonlinear eigenvalue problem. It is shown that there is an inherent tension between boundedness of the solution, boundedness of its derivatives, and the entropy condition. The special case of a constant-speed cavity collapse is considered and found to be heuristically possible, contrary to common intuition. Finally, we give an example of a concrete non-ideal collapsing cavity scaling solution based on a recently proposed pseudo-Mie-Gruneisen equation of state.
description: 20 pages, 3 figures, accepted at Qu. J. Mech. Appl. Math
In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2
Creators: name: Prasanth, D. S. N. B. K.
name: Murahari, Manikanta
name: Chandramohan, Vivek
name: Panda, Siva Prasad
name: Atmakuri, Lakshmana Rao
name: Guntupalli, Chakravarthi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Cinnamon has been utilized to remedy a lot of afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our research study is intended to recognize the phyto-derived antiviral substances from Cinnamon against COVID-19 main protease enzyme and to understand the in silico molecular basis of its activity. In the present study, 48 isolates compounds from Cinnamon retrieved from the PubMed database, are subjected to docking analysis. Docking study was performed using Autodock vina and PyRx software. Afterwards, admetSAR, as well as DruLiTo servers, were used to investigate drug-likeness prophecy. Our study shows that the nine phytochemicals of Cinnamon are very likely against the main protease enzyme of COVID-19. Further MD simulations could identify Tenufolin (TEN) and Pavetannin C1 (PAV) as hit compounds. Utilizing contemporary strategies, these phyto-compounds from a natural origin might establish a reliable medication or support lead identification. Identified hit compounds can be further taken for in vitro and in vivo studies to examine their effectiveness versus COVID-19. Communicated by Ramaswamy H. Sarma
Zum Forschungsstand der mittelneolithischen Kreisgrabenanlagen in Österreich
Creators: name: Trnka, Gerhard
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19
Creators: name: Selvaraj, Chandrabose
name: Dinesh, Dhurvas Chandrasekaran
name: Panwar, Umesh
name: Abhirami, Rajaram
name: Boura, Evzen
name: Singh, Sanjeev Kumar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) calls the whole world into a medical emergency. For tackling Coronavirus Disease 2019 (COVID-19), researchers from around the world are swiftly working on designing and identifying inhibitors against all possible viral key protein targets. One of the attractive drug targets is guanine-N7 methyltransferase which plays the main role in capping the 5′-ends of viral genomic RNA and sub genomic RNAs, to escape the host’s innate immunity. We performed homology modeling and molecular dynamic (MD) simulation, in order to understand the molecular architecture of Guanosine-P3-Adenosine-5’,5’-Triphosphate (G3A) binding with C-terminal N7-MTase domain of nsp14 from SARS-CoV-2. The residue Asn388 is highly conserved in present both in N7-MTase from SARS-CoV and SARS-CoV-2 and displays a unique function in G3A binding. For an in-depth understanding of these substrate specificities, we tried to screen and identify inhibitors from the Traditional Chinese Medicine (TCM) database. The combination of several computational approaches, including screening, MM/GBSA, MD simulations, and PCA calculations, provides the screened compounds that readily interact with the G3A binding site of homology modeled N7-MTase domain. Compounds from this screening will have strong potency towards inhibiting the substrate-binding and efficiently hinder the viral 5’-end RNA capping mechanism. We strongly believe the final compounds can become COVID-19 therapeutics, with huge international support. The focus of this study is to screen for antiviral inhibitors blocking guanine-N7 methyltransferase (N7-MTase), one of the key drug targets involved in the first methylation step of the SARS-CoV-2 RNA capping mechanism. Compounds binding the substrate-binding site can interfere with enzyme catalysis and impede 5’-end cap formation, which is crucial to mimic host RNA and evade host cellular immune responses. Therefore, our study proposes the top hit compounds from the Traditional Chinese Medicine (TCM) database using a combination of several computational approaches. Communicated by Ramaswamy H. Sarma.
Additional file 1: of Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models
Creators: name: Yu, You
name: Qin, Nianci
name: Lu, Xing-Ai
name: Li, Jingjing
name: Han, Xinglong
name: Ni, Xuan
name: Ye, Lingqun
name: Shen, Zhenya
name: Chen, Weiqian
name: Zhao, Zhen-Ao
name: Lei, Wei
name: Hu, Shijun
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Developmental Biology

description: Figure S1. Generation of reporter-engineered human embryonic stem cells (ESC-Rep). (A) Schematic diagram of CRISPR/Cas9-mediated homologous recombination in AAVS1 locus of PPP1R12C gene. (B) Procedure of ESC-Rep generation. Figure S2. Stage-specific gene expression during cardiomyocyte differentiation. Real-time PCR analysis for markers of pluripotency (POU5F1 and NANOG), mesoderm (T and MIXL1), cardiac mesoderm (MESP1 and EVX1), cardiac progenitors (NKX2.5 and GATA4), and cardiomyocytes (MYH6, MYH7, and TNNI3) during the cardiac differentiation. Figure S3. Characteristics of ESC-Rep-CMs. (A) Flow cytometry assay for troponin T (TNNT2)-positive cardiomyocytes after purification. (B) Patch clamp for electrophysiological characteristics of ESC-Rep-CMs. Figure S4. Postoperative cardiac evaluation in mice. (A) Electrocardiogram analysis of mice in the Sham, PI, and IR groups after surgery. (Bâ D) Heart function analysis of mice in the Sham, PI, and IR groups at day 7 post surgery. All data are presented as the mean Âą SEM; one-way ANOVA; *p < 0.05, **p < 0.01. Table S1. Primers used in this study. Table S2. Antibodies used in this study. Table S3. Cardiac parameters acquired from echocardiography at Day 28. (DOCX 12013 kb)
Natural compounds from Clerodendrum spp. as possible therapeutic candidates against SARS-CoV-2: An in silico investigation
Creators: name: Pallab Kar
name: Sharma, Neeta Raj
name: Bhupender Singh
name: Arnab Sen
name: Roy, Ayan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has rattled global public health, with researchers struggling to find specific therapeutic solutions. In this context, the present study employed an in silico approach to assess the inhibitory potential of the phytochemicals obtained from GC-MS analysis of twelve Clerodendrum species against the imperative spike protein, main protease enzyme Mpro and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. An extensive molecular docking investigation of the phytocompounds at the active binding pockets of the viral proteins revealed promising inhibitory potential of the phytochemicals taraxerol, friedelin and stigmasterol. Decent physicochemical attributes of the compounds in accordance with Lipinski’s rule of five and Veber’s rule further established them as potential therapeutic candidates against SARS-CoV-2. Molecular mechanics-generalized Born surface area (MM-GBSA) binding free energy estimation revealed that taraxerol was the most promising candidate displaying the highest binding efficacy with all the concerned SARS-CoV-2 proteins included in the present analysis. Our observations were supported by robust molecular dynamics simulations of the complexes of the viral proteins with taraxerol for a timescale of 40 nanoseconds. It was striking to note that taraxerol exhibited better binding energy scores with the concerned viral proteins than the drugs that are specifically targeted against them. The present results promise to provide new avenues to further evaluate the potential of the phytocompound taraxerol in vitro and in vivo towards its successful deployment as a SARS-CoV-2 inhibitor and combat the catastrophic COVID-19. Communicated by Ramaswamy H. Sarma
Umfriedungen und befestigte Siedlungen aus dem Äneolithikum Böhmens. Versuch einer kulturhistorischen Interpretation
Creators: name: Pleslová-Stiková, Emilie
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2024

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 73 (1990): Jahresschrift für Mitteldeutsche Vorgeschichte
title: ESLO1: interview de personnalité 438_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Sum rules for asymptotic form factors in $e^+ e^- -> W^+ W^-$ scattering
Creators: name: Feruglio, F.
name: Rigolin, S.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: At very large energies and in $SU(2)_L\otimes U(1)_Y$ gauge theories, the trilinear gauge boson vertices relevant for $e^+e^- \to W^+W^-$ scattering are related in a simple way to the gauge boson self-energies. We derive these relations, both from the requirement of perturbative unitarity and from the Ward Identities of the theory. Our discussion shows that, in general, it is never possible to neglect vector boson self-energies when computing the form factors which parametrize the $e^+ e^- \to W^+ W^-$ helicity amplitudes. The exclusion of the self-energy contributions would lead to estimates of the effects wrong by orders of magnitudes. We propose a simple way of including the self-energy contributions in an appropriate definition of the form factors.
description: 16 pages, latex file, 2 eps figures, need epsfig.sty
Structural insights into the extraction mechanism of cobalt(II) with dinonylnaphthalene sulfonic acid and 2-ethylhexyl 4-pyridinecarboxylate ester
Creators: name: Zhu, Shan
name: Huiping Hu
name: Jiugang Hu
name: Jiyuan Li
name: Hu, Fang
name: Yongxi Wang
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: In this work, to elucidate the synergistic extraction mechanism of cobalt(II) with dinonylnaphthalene sulfonic acid (HDNNS) and 2-ethylhexyl 4-pyridinecarboxylate ester (L), hexaaquacobalt(II) naphthalene-2-sulfonate (compound 1) was prepared using naphthalene-2-sulfonic acid (HNS, the short chain analog of HDNNS) and di-methyl isonicotinate tetraaquacobalt(II) naphthalene-2-sulfonate (compound 2) was prepared using methyl isonicotinate (LI, a short chain analog of 2-ethylhexyl 4-pyridinecarboxylate ester) and HNS; the compounds were studied by single crystal X-ray diffraction. Moreover, 2 and the actual extracted cobalt(II) complex were further investigated by Fourier transform infrared spectroscopy (FT-IR) and electrospray ionization mass spectrometry (ESI-MS). The results indicated that the actual extracted cobalt(II) complex possesses a similar coordination structure as 2. Combined with the results obtained by single crystal X-ray diffraction of 1 and 2, FT-IR and ESI-MS of 2 and the actual extracted cobalt(II) complex, it is reasonable to conclude that the extracted cobalt(II) complex with the actual synergistic mixture is much more stable than the cobalt(II) complex with HDNNS alone. Therefore, the extraction selectivity cobalt(II) is effectively enhanced with the addition of 2-ethylhexyl 4-pyridinecarboxylate ester to HDNNS.