cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterization of a novel class of glyoxylate reductase belonging to the β-hydroxyacid dehydrogenase family in Acetobacter aceti
Creators: name: Kumsab, Jakkaphan
name: Tobe, Ryuta
name: Kurihara, Tatsuo
name: Hirose, Yuu
name: Omori, Taketo
name: Mihara, Hisaaki
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Enzymes related to β-hydroxyacid dehydrogenases/3-hydroxyisobutyrate dehydrogenases are ubiquitous, but most of them have not been characterized. An uncharacterized protein with moderate sequence similarities to Gluconobacter oxydans succinic semialdehyde reductase and plant glyoxylate reductases/succinic semialdehyde reductases was found in the genome of Acetobacter aceti JCM20276. The corresponding gene was cloned and expressed in Escherichia coli. The gene product was purified and identified as a glyoxylate reductase that exclusively catalyzed the NAD(P)H-dependent reduction of glyoxylate to glycolate. The strict substrate specificity of this enzyme to glyoxylate, the diverged sequence motifs for its binding sites with cofactors and substrates, and its phylogenetic relationship to homologous enzymes suggested that this enzyme represents a novel class of enzymes in the β-hydroxyacid dehydrogenase family. This study may provide an important clue to clarify the metabolism of glyoxylate in bacteria. Abbreviations: GR: glyoxylate reductase; GRHPR: glyoxylate reductase/hydroxypyruvate reductase; HIBADH: 3-hydroxyisobutyrate dehydrogenase; SSA: succinic semialdehyde; SSAR: succinic semialdehyde reductase AceGR is NAD(P)H-dependent glyoxylate reductase representing a novel class of enzymes in the β-hydroxyacid dehydrogenase family.
Salem
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1880

description: Es handelt sich bei der Aufnahme um einen Albuminabzug
description: Unbekannte/r Fotograf/in
description: Abzug mit handschriftlicher Notiz auf der Rückseite der Unterlage
description: Der Abzug ist auf Karton montiert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Computational convection thermal analysis on spinning microfluidic disk digital polymerase chain reaction platform
Creators: name: Clavijo, Cristian Esteban
Publisher: name: University of Utah
Year: 2012
Subjects: Computational
Convection
Disk
Heat transfer
Microfluidic
PCR

description: There have been tremendous advancements in the field of genetic engineering within the past century. Digital Polymerase Chain Reaction (PCR) is a molecular diagnostic process, extensively used in genetics research, in which a single DNA sequence per control volume is amplified by undergoing thermal cycling between two temperatures limits, generally 55 °C and 95 °C. This paper presents an analysis of the convection thermal effects associated with different design parameters for a spinning digital PCR disk containing a helix microchannel containing a thousand nano-wells, which serve as the control volumes for the DNA solution. Further understanding and management of these design parameters is needed to optimize the design and operation of the digital PCR technology. The parameters studied in this work are the location, Reynolds number and temperature of the heating/cooling air source, the PCR disk spinning rate, and the thermocycler volume size. Changes in these parameters significantly affect the heating and cooling cycle rates, as well as the temperature uniformity of the disk. The impingement location of the air jet on the disk has a significant impact on the heating process time (9% maximum change). However, the impingement location dramatically affects temperature uniformity on the disk (173% maximum change). The impinging air jet Reynolds number contributed to both process time and temperature uniformity by a 90% change. Temperature uniformity was adversely affected for Reynolds numbers greater than 30x103.
Sonnenfleckenzeichnung Nr. 23284.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.02.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.01.1970, erstellt von Gisèle Evrard-Kesteloot, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
[Ansicht von Altkirch]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: Unbekannte/r Fotograf/in
description: Es handelt sich bei der Aufnahme um einen Albuminabzug
description: Die Aufnahme ist auf Karton montiert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Antibody-directed delivery of copper-67 to tumors
Creators: name: Bhalgat, Mahesh Kantilal
Publisher: name: University of Utah
Year: 2012
Subjects: Monoclonal Antibodies
Raiommunoconjugates

description: The advent of monoclonal antibodies led to the reawakening of the 'magic bullet' concept of Ehrlich, which suggests that antibodies against tumor-associated antigens could potentially be used for the delivery of cytotoxic agents specifically to tumors. The rationale for the use of such antibodies as selective carriers for the site-specific delivery of anticancer agents, and for increasing the therapeutic index of anticancer agents, is based on observations that antitumor antibodies or their immunologically reactive fragments do indeed selectively localize in vivo. Because in vivo localization of parenterally administered antitumor antibodies can be achieved, it has become feasible to investigate the efficiency and benefits of both diagnostic imaging as well as radiotherapy, using antibodies labeled with appropriate radioisotopes. Whole antibody molecules and their fragments were used for the synthesis of radioimmunoconjugates. A radioisotope with both therapeutic and diagnostic utility, copper-67, was attached to a renal cell carcinoma antibody, A6H, or its fragments, using a synthetic porphyrin for chelation. A panel of conjugates was synthesized, either by direct attachment of the porphyrin to the protein or via the use of intermediate polymeric molecules. Each of the synthesized conjugates was subjected to in vitro testing to determine the coupling yield, radiometalation yield, immunoreactivity, cell binding ability, and aggregation properties. The copper-67-A6H conjugate with the highest level of immunoreactivity was injected in nude mice and its biodistribution was studied. Although a respectable tumor to blood ratio of 16 was obtained 45 hours after injection, the liver and spleen radioactivity levels were unusually high. Further investigation led to the possibility that aggregates present in the injection solution may be responsible for the high uptake of the conjugates by the reticuloendothelial system. Dendrimer molecules used as polymeric intermediates in the immunoconjugates were subjected to preliminary biological evaluation to determine their toxicity, immunogenicity, carcinogenicity, and biodistribution pattern. Results from these experiments suggest that low doses of lower generation dendrimers are not associated with adverse effects that would preclude their use as intermediates in drug delivery.
Sonnenfleckenzeichnung Nr. 23295.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.03.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells
Creators: name: Okamoto, Shuichiro
name: Miyano, Kei
name: Kajikawa, Mizuho
name: Yamauchi, Akira
name: Kuribayashi, Futoshi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Autophagy induced in cancer cells during chemotherapy is classified into two types, which differ depending on the kind of cells or anticancer drugs. The first type of autophagy contributes to the death of cells treated with drugs. In contrast, the second type plays a crucial role in preventing anticancer drug-induced cell damages; the use of an autophagy inhibitor is considered effective in improving the efficacy of chemotherapy. Thus, it is important to determine which type of autophagy is induced during chemotherapy. Here, we showed that a novel inhibitor of RNA polymerase I, suppresses growth, induces cell cycle arrest and promotes apoptosis in leukemia cell lines. The number of apoptotic cells induced by co-treatment with CX-5461 and chloroquine, an autophagy inhibitor, increased compared with CX-5461 alone. Thus, the autophagy which may be induced by CX-5461 was the second type. The number of apoptotic cells induced by co-treatment with CX-5461 and CQ increased compared with CX-5461 alone.
Transitioning burn patients from parenteral to oral opioid pain medication: are they receiving equianalgesic doses
Creators: name: Moss, Lee Scott
Publisher: name: University of Utah
Year: 2012
Subjects: Drug Therapy
Narcotics

description: The purpose of this study was to determine if burn patients at a regional burn center were transitioned from parenteral to oral opioid pain medications in equianalgesic doses according to guidelines for acute pain management published by the Agency for Health Care Policy and Research (AHCPR). A descriptive study was completed using a retrospective chart review. Subjects included 30 previously healthy burned adults. All opioid medications were recorded and converted to parenteral morphine equivalents. Statistically significant differences were observed between parenteral and oral opioids ordered and between parenteral and oral opioids administered. It is concluded that patients were not transitioned from parenteral to oral opioid medications in equianalgesic doses according to AHCPR guidelines. Retrospective chart reviews have inherent limitations important to this study. Future research should include prospective studies comparing the use of AHCPR acute pain management guidelines with other pain management strategies.
[Ansicht auf Saint-Dié]
Creators: name: Franck, V.
Publisher: name: [s.n.]
Year: 1870

description: V. Franck
description: Es handelt sich bei der Aufnahme um einen Albuminabzug
description: Die Aufnahme ist auf Karton montiert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Influence of abiotic conditions on the biofouling formation of flagellated microalgae culture
Creators: name: García-Abad, Lucía
name: López-Rosales, Lorenzo
name: del Carmen Cerón-García, María
name: Fernández-García, Marta
name: García-Camacho, Francisco
name: Molina-Grima, Emilio
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This work analyses the adhesion of flagellated microalgae to seven surfaces that have different water adhesion tension characteristics. Chlamydomonas reinhardtii and Isochrysis galbana, were cultivated in batch and fed-batch mode at four nitrogen/phosphorus (N/P) ratios (from 1.29 to 70) and subjected to four irradiance levels (50, 100, 200 and 400 µE·s−1·m−2) at 23 °C. Cell adhesion was greater in C. reinhardtii and a higher biomass concentration was obtained for this strain, reaching 2 g·L−1 compared to 1 g·L−1 for I. galbana. The adhesion of cells and exopolymeric substances was measured upon the batch and the first fed-batch reaching the stationary growth phase, observing a direct correlation between them and inversely to biomass generation in the cultures. The protein adhesion data for the different materials are comparable to those for cell adhesion coinciding with minimums of Baier's theory and Vogler. It is observed displacements in the curves as a function of the irradiance level.
Embodying eclecticism from potential to actualization
Creators: name: Ramos, Alysia
Publisher: name: University of Utah
Year: 2014
Subjects: Choreography
Composition
Dance
Eclecticism
Embodiment
Nomadic theory

description: This thesis examines a disjunction, or marked contrast, between dance training encompassing diverse and multiple approaches and the increasingly narrow representations of modern dance in technique and choreography. If modern dance is to be understood as deriving from a belief that dance can constitute a form of individual, artistic expression, then its over reliance on limited forms must be called into question. The critical and creative examination, based on creative and theoretical research presented herein, gives way to a central argument: If it is to evolve, and better reflect the complexities of modern life, contemporary dance must return to its earlier emphasis on personal and boundless artistic expression. This paper presents a compositional method driven by dancers' eclectic training in the choreographic process. In doing so, creative and theoretical research is utilized to contend that somatic practice and improvisation combined with multiple dance techniques yields a more inclusive, relevant, and vital vision for contemporary dance.
Theory of elder Chinese-American's conceptions of health promotion and illness prevention: conformity with nature
Creators: name: Chen, Yeou-Lan Duh
Publisher: name: University of Utah
Year: 2012
Subjects: Aged
Asian American
Attitude to Health
Gerontology
Utah

description: The purpose of this study was to generate a substantative theory that describes and explains the perceptions of health and illness and the beliefs and behaviors of promoting and preventing illness among the Chinese elderly in the United States. Grounded theory methodology was used in this study. Theoretical sampling and constant comparative analysis were two strategies that directed the overall research process. Data were collected by interviewing 21 Chinese elderly who had immigrated from Taiwan, Republic of China, and were presently living in Salt Lake City, Utah. In addition to interviews, participants also kept health diaries for 1 week. Data from the diaries were analyzed with the interview data. The theory, Conformity with Nature, emerged from the data. This theory, based upon the perspective of the Chinese elders, describes the process of knowing nature and trying one's best to modify oneself to fit the laws of nature. Nature refers to all things and events that surround one, for example, sunshine, animals, plants, people, and even supreme beings. These things are offered by nature and are necessary for human survival. The laws of nature imply that natural phenomena have rhythms. The theory has three interrelated subprocesses: Harmonizing with the Environment, Following Bliss, and Listening to Heaven. The core variable, Conformity with Nature, emerged from these three subprocesses. Harmonizing with the Environment is a process of finding and creating harmony with the natural laws. Opening, adjusting, and expanding are three properties of this subprocess. Following Bliss is a process of choosing a course of action and attitude to lead a person toward his or her ideal for a happy life. There are three properties of Following Bliss: optimizing, esteeming, and re-creating. Listening to Heaven is a way of knowing and accepting the divine purpose in life and living in the knowledge of that purpose. Believing, accepting, and transcending are three properties of Listening to Heaven. This theory can enhance nurses' understanding of ways to promote health and prevent illness among the Chinese elderly. The theoretical framework offers a guide to providing quality health care to the Chinese elderly in the United States.
[Colmar Madonna]
Creators: name: Meyer, Ant
name: Schongauer, Martin
Publisher: name: [s.n.]
Year: 1870

description: Das Foto zeigt die sogenannte Madonna am Rosenhag von Martin Schongauer
description: Der Fotograph kann nicht näher identifiziert werden
description: Es handelt sich bei der Aufnahme um einen Albuminabzug
description: Die Aufnahme ist auf Karton montiert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.01.1970, erstellt von Vasile Dinulescu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
The relationship of fathers with sons who have Tourette Syndrome and the impact on the family
Creators: name: Cazier, Calvert F.
Publisher: name: University of Utah
Year: 2012
Subjects: ADHD
Comorbidity
OCD
Resiliency
Tourette syndrome

description: Tourette syndrome (TS) is a misunderstood complex, chronic, neuropsychiatric disorder known for both involuntary muscle and vocal tics which manifests itself in childhood and usually has a lifelong duration. Little research has been done on how families are impacted by having a child with (TS) and even less has been done on how fathers in particular are affected. Dealing with a child who has TS can be stressful to the parents as well as to the dynamics of and the family. While children with TS have many obvious challenges, their families face similar problems which may not be so readily apparent. This study used qualitative research methods to study the relationships of fathers and their sons with TS. Qualitative research is useful for examining aspects of social life that are not easily accessed through quantitative data collection techniques. The overarching finding which emerged in this study was that the fathers experienced a waxing and waning pattern of response in the face of an uncertain future which seemed to be influenced by the intrinsic nature of TS. They reported experiences along a continuum of success, ranging from effective responses which seemed to lead to personal growth and resilience and stronger relationships with their sons and families, to ineffective responses, difficulty developing personally, and relationship strain or deterioration. The waxing and waning pattern of responses occurred along five major themes: 1) the question of normalcy, 2) pride in son, 3) hope in the future, 4) acceptance, and 5) role satisfaction. Each father had his own unique challenges to his son with TS which impacted his relationships with this son, his other children, and his wife. As a whole these fathers appeared to find effective ways over time to develop strong family relationships. Factors which seemed to propel these fathers forward included a clear understanding of and commitment to their roles as a father and husband and the successful development of a strong husband and wife team.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.02.1970, erstellt von Simona Nicolescu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.02.1970, erstellt von Gisèle Evrard-Kesteloot, Observatoire Royal de Belgique in Uccle
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage in Uccle. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt.
Instrument: Merz-Grubb Refraktor Teleskop (Öffnung 160 mm, f = 2450 mm, projiziertes Sonnenbild D = 25 cm)
Excess pore pressure and in situ measurement of shear strength gain in clays
Creators: name: Baghoomian, Ovaness
Publisher: name: University of Utah
Year: 2012
Subjects: Soils -- Testing
Clay -- Analysis

description: study compares predicted and field measured excess pore pressures  in a soft, saturated clay subjected to an embankment loading. It  compares the increases in soil strength due to consolidation as measured  with in situ vane shear, unconfined compression, and triaxial test methods.  The predicted pore pressures were obtained from the equation:  Au-B Aa3+A Adj - Acr3  The A and B parameters in the equation were determined from triaxial pore  pressure measurements. The principal incremental stresses Ao"| andAcr^  were obtained using the Finite Element and Elastic Theory methods of  stress analysis. The influence of the loading rate, soil consolidation,  and permeability on pore pressure development were also investigated.  Field pore pressures were measured with hydraulic and pneumatic type piezometers.  The results indicate that there is reasonably close agreement between  the predicted and field measured pore pressures using stresses  determined by the Finite Element method. The predicted pore pressures  determined ty the Elastic Theory method were considerably higher than the  measured pore pressures. The equation used for predicting pore pressures  assumes no pore pressure dissipation during construction. This assumption  was shown unvalid for soils in this area because there was a continuous  dissipation of pore pressure during embankment construction.  The in situ vane shear test values were nearly of the same magnitude  as those obtained by the conventional unconfined compression and triaxial  test methods, except for soft to very soft clays where the vane shear  test results were considerably higher. For soft to very soft clays the  triaxial and the vane test results were in close agreement but the samples  in triaxial tests had to be initially back pressure saturated and  then completely consolidated under the in sicu overburden pressure. The  increase in soil strength due to consolidation was not constant for all  soils. Some clays gained more strength than the others for equal consolidation  pressures. Quick clays lost strength during the initial  stages of soil consolidation. With the exception of soft to very soft  clays most clays developed about 70 percent of their ultimate strength  gain during the initial 40-50 percent soil consolidation. In soft clays  most of the strength gain took place during the final stages of soil  consolidation.
Research Environments and Research Integrity: An Educational Scenario by the EnTIRE project
Creators: name: Lewis, Jonathan
Publisher: name: Zenodo
Year: 2020
Subjects: research integrity
research ethics

description: Members of The Embassy of Good Science have developed a set of eight scenarios for educational purposes and to stimulate strategic thinking about issues in research ethics and research integrity. This scenario presents a hypothetical narrative concerning the links between research environments and research integrity. It focuses on issues regarding: Communication of the standards governing research integrity by universities and research organisations; Environmental pressures to commit research misconduct; Whistleblowing and the monitoring of research misconduct; Barriers to reporting cases of research misconduct; Power imbalances between students/early-career researchers and senior academics. It is interspersed with questions and resource suggestions that help guide researchers, research ethics committees ('RECs'), research integrity offices ('RIOs') and research administrators in their deliberations concerning the research integrity issues raised by the narrative.
Function of PoLAE2, a laeA homolog, in appressorium formation and cAMP signal transduction in Pyricularia oryzae
Creators: name: Prajanket, Pradabrat
name: Vu, Kim-Chi Thi
name: Arai, Jun
name: Sornkom, Worawan
name: Abe, Ayumi
name: Sone, Teruo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: A novel homolog of laeA, a global regulatory gene in filamentous fungi, was identified from Pyricularia oryzae. A deletion mutant of the homolog (PoLAE2) exhibited lowered intracellular cAMP levels, and decreased appressorium formation on non-host surface; the decrease was recovered using exogenous cAMP and IBMX, indicating that PoLAE2 deletion affected the cAMP signaling pathway.
Sonnenfleckenzeichnung Nr. 23300.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.03.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.03.1970, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Nonequilibrium morphologies of random block copolymers processed by solvent evaporation
Creators: name: Hambrecht, Keith Richard
Publisher: name: University of Utah
Year: 2012
Subjects: Block copolymer
FENE
Molecular dynamics
Polymer membrane
Solvent evaporation

description: This thesis describes the investigation of solvent evaporation processing of random block copolymers and its effects on morphology. Molecular dynamics simulations were performed on a coarse-grained bead spring model of a generic random block copolymer. A standard Lennard-Jones nonbonded potential and a finitely extensible nonlinear elastic (FENE) bonded potential were used. The model was first characterized without the use of solvent processing by ‘quenching' the polymer. The Lennard-Jones well depth, ?, was increased for one monomer to produce a block copolymer with blocks of different glass transition temperatures. A co-solvent was then added and the evaporation process was carried out by randomly removing solvent particles from the simulation box. The effect of the solvent evaporation process on morphology was investigated and compared to the quenched polymer. Effect of the strength of solvent, evaporation rate, and Lennard-Jones well depth were all looked at. It was concluded that quenching of random block copolymer melts under conditions where one of the blocks is glassy leads to a kinetically arrested morphology. This morphology has a smaller domain size and more extended chain conformation than the morphology when both blocks are nonglassy. Solvent evaporation processing, however, reduces these effects and produces a larger domain size.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.04.1970, erstellt von Georgeta Maris, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 23306.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.03.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23287.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.03.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23312.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.04.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23281.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.02.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23286.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.03.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen
Sonnenfleckenzeichnung Nr. 23272.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.02.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
[36 Ansichten von der Region Tirol]
Creators: name: Schmidt, Otto
name: Photochrom Zürich
name: Wehrli AG
name: Kunstverlag Otto Schmidt
name: Strengel & Co
Publisher: name: Strengel & Co; Kunstverlag Otto Schmidt; P.Z; Wehrli A.G.
Year: 1890

description: [Partie bei Gries im Sellrain]
description: [Pertisau am Achensee]
description: [Scholastica am Achensee]
description: 8652. Arco e Val di Sarca
description: [Arco]
description: 16072 Motivo presso Arco
description: 830. Bozen. Pfarrkirche
description: Brenner-Bad 315.
description: [Brenner]
description: 781 b Brixen
description: 1268. Brixen. Grabstein Oswald von Wolkenstein
description: 557. Kreuzgang in Brixen
description: 17362. Tirol. Brixlegg
description: [Brückele]
description: Bruneck
description: 866. Burgels mit Fürstenburg
description: [Caldonazzosee]
description: Panorama di Cles in Val di Non.
description: Gastel. Cles in Val di non
description: 175. Cortina mit Scrapass [...]
description: 176. Cortina [...]
description: 2802 Karersee
description: 2800 Karersee Hotel
description: 360. Ampezzo Misurinasee
description: 289. Dürrensee [...]
description: Bad Egerdach bei Innsbruck 263.
description: 8780. Eggenthal. Karneid
description: [Eggental]
description: 914. Ehrenberger Klause [...]
description: [Fieberbrunn]
description: 877. Alt-Finstermünz
description: 578. Hoch Finstermünz Aussicht gen Süden
description: 1364. Schloss Forst
description: [Fulpmes]
description: 902. Glurns g.d. Ortler
description: 912. Graun G D Ortler
description: Otto Schmidt ; [und weitere]
description: Nicht alle Fotografien können einem Verlag zugeordnet werden
description: Abzüge mit handschriftlicher Notiz auf den Rückseiten der Unterlagen; die Jahreszahlen wurden zu einem späteren Zeitpunkt notiert, die betroffenen Abzüge wurden wahrscheinlich erst später in die Ansichtensammlung La Roche einsigniert
description: Nicht alle Fotografien können einem Urheber zugeschrieben werden
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Sonnenfleckenzeichnung Nr. 23275.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.02.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen
OpenAPC - A contribution to transparency in fee-based Open Access publishing
Creators: name: Broschinski, Christoph
Publisher: name: Zenodo
Year: 2016

description: With the ongoing transition to Open Access publishing, the topic of Article Processing Charges (APCs) becomes more and more prevalent, as publication fees on article basis are slowly but constantly transforming and replacing the traditional methods of subscription-based access to scientific publications for involved institutions and libraries. However, as with established models, cost intransparencies have also remained an issue with APCs, making comparisons and evaluations difficult and posing a severe problem for institutional negotiators and policy makers. Following the implementation of Open Access Publishing Fonds in Germany by the German Research Foundation (DFG), the OpenAPC initiative was established at Bielefeld University Library in 2014 with the support of the DINI Working Group Electronic Publishing. OpenAPC approached universities with DFG-funded Publication Fonds and several of them agreed to share their APC expenditures, applying an Open Data approach to Article Processing Charges. To make the process of data collection, processing and presentation as transparent and reproducible as possible, a GitHub repository was created as central working platform (https://github.com/OpenAPC/openapc-de). In October 2015 OpenAPC teamed up with the ESAC initiative (Max Planck Digital Library) and the OA Analytics Group (I²SoS, Bielefeld University) to form the DFG-funded project INTACT (http://intact-project.org/). With a constantly growing set of participating institutions, OpenAPC now holds data from 35 institutions both national and international, ranging from small universities over research centers up to large science funders like the FWF or the Wellcome Trust. At the moment, OpenAPC manages a dataset of over 14300 articles, with APC costs summarizing to more than 25 million Euro. This presentation will give an overview over the OpenAPC project and its recent activities. We will introduce our GitHub repository and show how distinctive GitHub features (Pull Requests, Revisions, Flavored Markdown...) can be utilised to support an Open Data project. We will address the problems of data consistency and integrity and how OpenAPC deals with them via automated metadata enrichment routines and Continuous Integration techniques. Finally, we will present our OLAP Server and Treemap visualisation site to show how the OpenAPC data can be analysed, visualised and disseminated in an advanced manner. Our presentation will conclude with an outlook on future plans and challenges like integration of an increasing number of partnering institutions and handling of non-standard APC billing models like offsetting contracts.
Sonnenfleckenzeichnung Nr. 23271.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.02.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
[12 Ansichten von Nieder-Österreich]
Creators: name: Helm's phot. Kunstverlag
name: Würthle & Sohn
Publisher: name: [Würthle & Sohn]; Helm's phot. Kunstverlag
Year: 1890

description: [Schloss Trautmannsdorf]
description: Stift Zwettl
description: Votivkirche von Oberbaurath (Wien)
description: [Dürnstein Kirchenportal]
description: [Dürnstein. Inneres der Kirche]
description: [Dürnstein. Portal des Chorherrenstiftes]
description: [Dürnstein. Alte Friedhofskirche]
description: [Dürnstein von der Strasse aus]
description: [Dürnstein Altes Schloss]
description: [Dürnstein Stadttor]
description: Ischl vom kais. Park
description: [Ischl]
description: Unbekannte/r Fotograf/in
description: Abzüge auf Kartons montiert
description: Abzüge mit handschriftlicher Notiz auf den Rückseiten der Unterlagen; die Jahreszahlen wurden zu einem späteren Zeitpunkt notiert, die betroffenen Abzüge wurden wahrscheinlich erst später in die Ansichtensammlung La Roche einsigniert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Cytotoxic and anti-diabetic potential, metabolic profiling and insilico studies of Syzygium cumini (L.) Skeels belonging to family Myrtaceae
Creators: name: Elhawary, Seham Salah Eldin
name: Elmotayam, Amira kamal Eldin
name: Alsayed, Doaa kamel
name: Zahran, Eman Maher
name: Fouad, Merivat Ahmed
name: Sleem, Amany Ameen
name: Elimam, Hanan
name: Rashed, Mohamed H.
name: Hayallah, Alaa M.
name: Mohammed, Anber F.
name: Abdelmohsen, Usama Ramadan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: LC-HR-MS-coupled metabolic profiling of the methanol extracts from different parts of Syzygium cumini (L.), which was extensively identified via DNA fingerprinting, led to dereplication of 24 compounds. Cytotoxic investigation highlighted both extracts as the most potent, against both MCF-7 and MDA-231 Cell lines, with IC50 value of 5.86 ± 0.63 µg/ml and against HCT −116 cell line, with IC50 value of 1.24 ± 0.09 µg/ml, respectively. A molecular docking study was performed on the dereplicated compounds, which highlighted myricetin-3-glucoside (7), myricitrin (12), reynoutrin (15) and quercitrin (16) as the top scoring ligands within the protein active site (FIH-1). Interestingly, the extracts were significant against streptozotocin-induced diabetes in the order of flowers > seeds > leaves with BGL level of 98.9 ± 4.3, 123.2 ± 4.9 and 132.8 ± 5.9 mg/dl, respectively. The study highlights the health benefits of Syzygium cumini (L.) as a promising cytotoxic source.
Genetic Screen and Functional Analysis of Steroid-Triggered Cell Death in Drosophila
Creators: name: Wang, Lei
Publisher: name: University of Utah
Year: 2012
Subjects: Drosophila
Cell Death
Steroids

description: The steroid hormone ecdysone triggers the stage-specific destruction of  Drosophila larval tissues through transcriptional cascades that induce two distinct forms  of programmed cell death: caspase-dependent apoptosis and lysosome-mediated  autophagy. In this thesis, I describe the use of genetic screens to further our  understanding of the steroid-triggered programmed cell death response. Pupal lethal  mutants were screened for specific defects in the destruction of larval salivary glands. A  pilot screen using existing collections of P-element insertions resulted in the  identification of known cell death regulators as well as mutations in novel regulators of  cell death, such as dCBP and dTrf2. A large-scale EMS mutagenesis screen on the third  chromosome identified 48 mutants, which include seven multiallelic complementation  groups. At least five of these groups represent novel regulators of cell death, three of  which were mapped to specific genes: CG5146, Med24, and CG7998.1 further  characterized two of these genes, Med24 and CG7998, for their roles in salivary gland  cell death. I showed that mutations in CG7998 and Med24 selectively block caspase  activation without affecting autophagy in persistent mutant salivary glands. CG7998  encodes a malate dehydrogenase that localizes to the mitochondria. Although  mitochondrial number and morphology appear normal in CG7998 mutant salivary glands,  these animals have significantly lower levels of ATP and accumulate late-stage citric acid  cycle intermediates, suggesting that the cell death defects arise from a deficit in cellular energy production. Med24 encodes a component of the Mediator transcriptional  coactivator complex. Unexpectedly, however, the ecdysone-induction of key death  regulator genes occurs normally in Med.24 mutant salivary glands. This study identifies  novel mechanisms for regulating the destruction of larval tissues during Drosophila  metamorphosis, and provides new directions for defining the molecular mechanisms of  steroid-triggered programmed cell death during development.