Additional file 1 of Environmental exposures in early-life and general health in childhood
Creators: name: Amine, Ines
name: Guillien, Alicia
name: Philippat, Claire
name: Anguita-Ruiz, Augusto
name: Casas, Maribel
name: de Castro, Montserrat
name: Dedele, Audrius
name: Garcia-Aymerich, Judith
name: Granum, Berit
name: Grazuleviciene, Regina
name: Heude, Barbara
name: Haug, Line Småstuen
name: Julvez, Jordi
name: López-Vicente, Mónica
name: Maitre, Léa
name: McEachan, Rosemary
name: Nieuwenhuijsen, Mark
name: Stratakis, Nikos
name: Vafeiadi, Marina
name: Wright, John
name: Yang, Tiffany
name: Yuan, Wen Lun
name: Basagaña, Xavier
name: Slama, Rémy
name: Vrijheid, Martine
name: Siroux, Valérie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: eMethods 1. Health outcomes assessment. eMethods 2. Urban exposure assessment methods (extracted from Maitre12). eMethods 3. Assessment methods for lifestyle factors and other (extracted from Maitre12). eMethods 4. Biomarker assessment methods (extracted from Maitre12). eMethods 5. Creation of the general health score. eMethods 6. Data pre-processing. eMethods 7. Exposome-health association study. eTable 1. Collection time points of health parameters in childhood (mean, SD). eTable 2. Biological matrices of maternal and child samples. eTable 3. Collection time points of prenatal exposures, eTable 4.Collection time points of maternal blood and urine samples (mean, SD). eTable 5. Standardization of the cardiometabolic parameters. eTable 6. Standardization of the mental and cognitive parameters. eTable 7. Factor analysis on respiratory and allergy-related parameters – Dimension 1. eTable 8. Factor analysis on mental and cognitive parameters – Dimension 1. eTable 9. Transformation applied to continuous postnatal exposures and IQR. eTable 10. Description of transformed urban exposures. eTable 11. Description of exposures regarding the lifestyle. eTable 12. Description of biomarkers in the Helix population. eTable 13. Description of the health parameters considered. eTable 14. Correlations between the three sub-scores. eTable 15. Description of the general health score by covariates. eTable 16. Description of the general health score divided in terciles with health parameters and- sub-scores. eTable 17. Complete results of the ExWAS on prenatal exposures. eTable 18. Complete results of the ExWAS on postnatal exposures. eTable 19. Final multivariable models with and without fish consumption as a confounder (results for postnatal PFOA). eFigure 1. Variable plot - Mixed Factorial Analysis on standardized variables of mental health (Helix subcohort, n=1278 with mental health data). eFigure 2. Variable plots - Mixed Factorial Analysis on standardized variables of respiratory health and allergies (Helix subcohort, n=1009 with respiratory and allergic data). eFigure 3. Distribution of each sub-score by cohort. eFigure 4. Multi-exposure model on postnatal exposures stratifiedon the terciles of z-BMI. eFigure 5. Multi-exposure model on prenatal exposures stratified on sex. eFigure 6. Multi-exposure model on postnatal exposures stratified on sex. eFigure 7. Multi-exposure model on postnatal exposures stratified on cohorts. eFigure 8. Multi-exposure model on postnatal exposures stratified on cohorts. eFigure 9. GAM estimated curve for postnatal selected exposures by LASSO. eFigure 10. Multi-exposure model without the 4% most extreme values for the general health score.