cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Linearity defect of edge ideals and Fröberg's theorem
Creators: name: Nguyen, Hop D.
name: Vu, Thanh
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics

description: Fröberg's classical theorem about edge ideals with $2$-linear resolution can be regarded as a classification of graphs whose edge ideals have linearity defect zero. Extending his theorem, we classify all graphs whose edge ideals have linearity defect at most $1$. Our characterization is independent of the characteristic of the base field: the graphs in question are exactly weakly chordal graphs with induced matching number at most $2$. The proof uses the theory of Betti splittings of monomial ideals due to Francisco, Hà, and Van Tuyl and the structure of weakly chordal graphs. Along the way, we compute the linearity defect of edge ideals of cycles and weakly chordal graphs. We are also able to recover and generalize previous results due to Dochtermann-Engström, Kimura, and Woodroofe on the projective dimension and Castelnuovo-Mumford regularity of edge ideals.
description: Final version, with minor corrections. To appear in J. Algebr. Combin
title: Usefulness of breast specific gamma scan in the interpretation of incidentally detected suspicious breast lesions on breast MRI or Ultrasonography among known breast cancer patients
Creators: name: Park, Chang Suk
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Biopsy
subject: Ultrasound
subject: Nuclear medicine conventional
subject: MR
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Mammography is basic diagnostic modality for breast cancer now. Because the accuracy of mammography is affected by breast density, breast ultrasonography(US) has been performed for evaluation of women having mammographic abnormality or dense breast...
title: Semiautomatische Personalisierung der Untersuchungsprotokolle in der thorakoabdominellen Computertomographie
Creators: name: Daniel, Sascha
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Einleitung In aktuellen Computertomographen gibt es zahlreiche Techniken zur Dosisreduktion oder Bildqualitätsverbesserung, um so die Untersuchung auf die Patienten anzupassen. Diese konsequent anzuwenden, benötigt jedoch das Knowhow und Zeit, die in der klinischen Routine sehr knapp bemessen ist. Ziel der Studie war es zu überprüfen, ob ein Entscheidungsbaum-gestütztes Tool zur CT-Planung Thorax-Abdomen-CTs zum Staging onkologischer Patienten personalisieren kann. Material und Methoden Auf einem neuen dual-energy-fähigen (DE) single-source CT wurde ein Entscheidungsbaum erstellt, der anhand der Auswahl des Radiologen (Atemanhaltekapazität, Gewicht, Scanbereich und Art der Metallimplantate) ein personalisiertes Untersuchungsprotokoll generiert ohne weitere Interaktion mit dem User zu benötigen. Es wurden 631 Untersuchungen retrospektiv ausgewertet und mit einem Kontrollkollektiv von 740 Scans verglichen, die an einem vergleichbaren CT ohne Entscheidungbäume durchgeführt wurden. Innerhalb eines Subkollektivs von 150 Untersuchungen pro Gruppe (dual energy vs low-kV single energy) wurde Bildqualität subjektiv mit einer Likert-Skala und objektiv als Kontrast-zu-Rausch-Verhältnis angepasst an die Strahlendosis verglichen. Ergebnisse Bei entscheidungsbaum-gestützter Protokollauswahl wurde in 64.2% Dual Energy benutzt und in 67.3 % der Fälle Metallartefakt-unterdrückende Rekonstruktionsalgorithmen (iMAR), falls benötigt. Im Referenzkollektiv waren die Dual-Energy-Nutzung mit 2.8% der Fälle und iMAR-Nutzung mit 44% der Fälle deutlich niedriger. Es wurde kein signifikanter Unterschied in der subjektiven Bildqualität gefunden. In der Auswertung der objektiven Bildqualität schnitten die DE-Untersuchungen signifikant besser ab (4.55/mGy vs 3.74/mGy, p=0.05). Darüber hinaus wurde in der DE-Subgruppe eine niedrigere effektive Dosis gemessen (7.7 mSv vs 10.1 mSv, p<0.001). Schlussfolgerung Entscheidungsbäume zur Untersuchungsplanung erhöhen die Rate von Dual-Energy-CTs und Metallartefakt-unterdrückenden Rekonstruktionsalgorithmen. Die Bildqualität bei DE-Untersuchungen ist bei niedrigerer Strahlendosis besser im Vergleich zu niedrig-kV Single-Energy-Untersuchungen. Durch die entscheidungsbaumgestützte Protokollplanung profitieren auf der einen Seite die Patienten durch niedrigere Strahlendosen und auf der anderen Seite die Radiologen durch die bessere Bildqualität.
Jet-based TMD measurements with H1 data
Creators: name: Arratia, Miguel
Publisher: name: Zenodo
Year: 2021
Subjects: jets
DIS
Electron-Ion Collider
HERA
machine learning
unfolding

description: Talk given at the DIS-2021 is the 28th in the series of annual workshops on Deep-Inelastic Scattering (DIS) and Related Subjects, Santiago de Compostela, Spain.
(101949) Edward Bargeer Wall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Optimizing linked cluster expansions by white graphs
Creators: name: Coester, K.
name: Schmidt, K. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We introduce a white graph expansion for the method of perturbative continuous unitary transformations when implemented as a linked cluster expansion. The essential idea behind an expansion in white graphs is to perform an optimized bookkeeping during the calculation by exploiting the model-independent effective Hamiltonian in second quantization and the associated inherent cluster additivity. This appoach is shown to be especially well suited for microscopic models with many coupling constants, since the total number of relevant graphs is drastically reduced. The white graph expansion is exemplified for a two-dimensional quantum spin model of coupled two-leg XXZ ladders.
description: 13 pages, 7 figures
title: Intima-media thickness evaluation of common carotid and internal carotid arteries by sonography in Type – 2 diabetes mellitus and its correlation with physical and biochemical parameters
Creators: name: Suthar, Pokhraj
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: Vascular
subject: Biological effects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate the carotid IMT in patients Type-2 Diabetes and in age and sex matched controls. To compare the IMT in both these groups. To study the correlation of IMT with physical and biochemical...
title: The Evolution of the Coverage of MWUs in Monolingual Advanced Learner's Dictionaries
Creators: name: Fu, Lihua
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: Advanced Learner's Dictionaries, Multi-word Units, MWU, Collocation, Lexicography, English Linguistics

description: Abstract The Evolution of the Coverage of MWUs in Monolingual Advanced Learner’s Dictionaries As MWUs (Multi-word Units) are essential for language teaching and learning and advanced learner’s dictionaries are the most reliable printed reference tools for learners of English, it is meaningful to have in-depth analyses about the coverage of the MWUs in monolingual advanced learner’s dictionaries diachronically and synchronically. The advanced learner’s dictionaries included in the present work are all the editions of OALD (Oxford Advanced Learner’s Dictionary), LDOCE (Longman Dictionary of Current English), CALD (Cambridge Advanced Learner’s Dictionary), COBUILD (Collins COBUILD Advanced Leaner’s Dictionary) and MEDAL (Macmillan English Dictionary for Advanced Learners). The aim of this research is not only to provide quantitative but also qualitative ones. As such, an overview of the development of the coverage of the MWUs researched systematically can be provided. Furthermore, the qualitative analyses can contribute to the representations of MWUs in practical lexicography. In total, 1,040 words that appear in every edition of the aforementioned dictionaries were selected. Their MWUs and representations were compiled and annotated in the data. Synchronic analyses were done from the coverage of the MWUs in the latest edition of each publishing company, i.e. OALD10, LDOCE6, CALD4, COBUILD 9 and MEDAL2. The statistical analyses indicate that the coverages of the word list’s MWUs of the five publishers are increasing, in general, over time. There are 2,363 MWUs of all the advanced learner’s dictionaries diachronically. The increasing figures can indicate that the studies on collocations have impact on practical lexicography. Based on qualitative analyses, extensive discussions on the phenomenon between splitting and lumping as well as word class are initiated. On this basis, it is recommended that the lexicographers should take the studies in linguistics into consideration. Further research in the field of corpus linguistics, cognitive linguistics and construction grammar can be beneficial to the development of practical lexicography.
Spript analisis de futbol goles-equipos premier league
Creators: name: Álvaro Fernández, Javier
Publisher: name: Zenodo
Year: 2023
Subjects: Analisis
plot
Grafica
goles
futbol
Deporte

description: Analisis de los goles que marco cada equipo de la premier en la temporada 2010-2011
description: {"references": ["Jordi Grau Escolano, & Albert Geli Taberner. (2021). Big 5 European football leagues: team and player stats [Data set]. Zenodo."]}
Medication Errors in Adolescents using Asthma Controller Medications
Creators: name: Henry Clark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Little is known regarding the types of errors that children make regarding their asthma medications. This project aims to discover the types of errors that adolescents most commonly make. Knowledge regarding these errors can be used by health care professionals in order to increase patient education and improve outcomes regarding asthma medication use in children.
Scaling Up: The Validation of Empirically Derived Scheduling Rules on NVIDIA GPUs
Creators: name: Bakita, Joshua J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Embedded systems augmented with graphics processing units (GPUs) are seeing increased use in safety-critical real-time systems such as autonomous vehicles. The current black-box and proprietary nature of these GPUs has made it difficult to determine their behavior in worst-case scenarios, threatening the safety of autonomous systems. In this work, we introduce a new automated validation framework to analyze GPU execution traces and determine if behavioral assumptions inferred from black-box experiments consistently match behavior of real-world devices.  We find that the behaviors observed in prior work are consistent on a small scale, but the rules do not stretch to significantly older GPUs and struggle with complex GPU workloads.
title: Towards Alkaline Earth Metal Complexes with Superbulky Amide Ligands and Highly Potent Alkene and Arene Hydrogenation Catalysts Based on Abundant Metals
Creators: name: Knüpfer, Christian
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Dissertationsschrift zur Erlangung des Doktorgrades Dr. rer. nat.
(101950) Henry Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: CNS infections in paediatric patients: what do you really need to keep an eye on?
Creators: name: Trujillo Ariza, Maria Virginia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Infection
subject: Imaging sequences
subject: Diagnostic procedure
subject: Complications
subject: Ultrasound
subject: MR
subject: CT
subject: Paediatric

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the most common etiologies of CNS infections in paediatric patients. Describe the standarized imaging approach for diagnosis, focussing on imaging diagnostic clues. Stablish a differential diagnosis based on anatomical imaging findings....
Parental Expressed Emotion and Adolescent Self-Injurious Thoughts and Behaviors
Creators: name: Dodson, Jillian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Self-injurious thoughts and behaviors (SITB) are a highly prevalent public health problem among adolescents. Despite this prevalence and the severe nature of SITB, predictors are not well known. Parental expressed emotion, which assesses the levels of criticism and emotional over-involvement (EOI) directed towards a child, is important to analyze when considering adolescent SITB. The current study analyzed associations among parental expressed emotion, adolescent SITB, and emotional reactivity within a sample of adolescent females. Parental expressed emotion and emotional reactivity were found to be significantly associated with adolescent SITB. Emotional reactivity did not moderate the relationship between parental expressed emotion and adolescent SITB. The current study adds to existing literature regarding the impact of parent-child relationships on adolescent SITB and provides insight for future research on the subject.
(101951) Mary Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Control of Three Invasive Annual Grasses in Utah Using Herbicides Including Indaziflam
Creators: name: Buell, Hailey L.
Publisher: name: Utah State University
Year: 2021

description: Invasive grasses pose a threat to rangeland ecosystems in Utah. Three grasses in particular: downy brome, medusahead, and ventenata can push out native plants and prevent other vegetation from germinating. These grasses can also degrade grazing lands for cattle and act as kindling for wildfires. The use of herbicides is the most common way to rid a site of invasive plants. Herbicides that prevent germination for many years work well to keep annual grasses at bay while not harming the many long-living native plants that are already growing.
A study was designed on a site infested with downy brome to test how well native plants tolerate a variety of herbicides. The main objective was to test for lone herbicides or combinations that do minimal damage to the native vegetation with maximum damage to downy brome.
Ventenata is an invasive grass that is new to Utah; thus, not much is known about how to control it. An experiment was designed to test different herbicides on a site invaded by ventenata and observe the effects on the surrounding native and weedy plants. A concurrent greenhouse study was designed to test three different herbicides on downy brome, ventenata, and medusahead to see how they react differently in controlled conditions compared to field conditions.
An experiment was designed to restore a site that had been completely overtaken by medusahead using herbicides. The site was sprayed with a variety of different herbicides. Native and other desirable plants were planted using a drill into the site in order to see which herbicides prevented medusahead germination while allowing maximum establishment of the plants that were seeded.
title: Imiglucerase shortage: effects on patients with Gaucher disease
Creators: name: Morales Pérez, Jose Manuel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genetic defects
subject: Comparative studies
subject: MR
subject: Bones

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Enzymatic replacement therapy with recombinant human glucocerebrosidase (imiglucerase, Cerezyme® Sanofi/Genzyme) may prevent the development of irreversible bone complications and, above all, usually corrects the pathological infiltration of the...
Ghostly action at a distance: a non-technical explanation of the Bell inequality
Creators: name: Alford, Mark G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We give a simple non-mathematical explanation of Bell's inequality. Using the inequality, we show how the results of Einstein-Podolsky-Rosen (EPR) experiments violate the principle of strong locality, also known as local causality. This indicates, given some reasonable-sounding assumptions, that some sort of faster-than-light influence is present in nature. We discuss the implications, emphasizing the relationship between EPR and the Principle of Relativity, the distinction between causal influences and signals, and the tension between EPR and determinism.
description: 12 pages, 5 figures, revised version, to be published in American Journal of Physics
Importance of Testing Rarer Alleles (CYP3A5*6 and CYP3A5*7) for Genotype-Guided Tacrolimus Dosing
Creators: name: Xue, Ivy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: In many studies of the pharmacogenetic effects of dosing the immunosuppressant drug, tacrolimus, a single allele of CYP3A5 (*3) is often the only one considered as it is the most frequent variant. This study’s purpose was to evaluate the incidence of two other CYP3A5 alleles when using
single-SNP assays for genotype-guided tacrolimus dosing. Here, we investigated three CYP3A5 alleles including the wildtype (*1) and nonfunctional (*3, *6, *7) alleles. CYP3A5 non-expressers have two
nonfunctional alleles, whereas patients with at least one wildtype allele are considered CYP3A5 expressers and are recommended to be started on a higher tacrolimus dose. Pharmacogenomic studies
have often only attempted to detect the presence of *3 for nonfunctional status and used a default to call of *1 in the absence of the *3 allele. The *3 allele is most common in Caucasians. The *6 and *7 alleles are more common in African Americans but are not routinely genotyped, resulting in potentially
miscalled CYP3A5 genotypes and reduced clinical benefit from genotype-guided dosing. This study assessed the importance of testing *6 and *7 alleles in a racially diverse kidney transplant recipient population. A comprehensive gene analysis may be beneficial for CYP3A5 genotype-guided tacrolimus dosing.
Heroin-Conditioned Immunomodulation in Female Rats: Examining the Role of Estrogen
Creators: name: Weckstein, Taylor
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Opioids suppress normal immune status, impairing user response to pathogens. Using well-controlled animal models, our laboratory has established that heroin and heroin-paired cues inhibit production of pro-inflammatory biomarkers in male rats when they precede an endotoxin challenge with lipopolysaccharide (LPS). However, whether this phenomenon exists in female rats requires further scientific examination. There are well documented sex-based differences in opioid and immune responses in male and female clinical populations. For example, evidence suggests estrogen inhibits the production of interleukin-1β (IL-1β), a pro-inflammatory cytokine necessary for the expression of heroin-conditioned immunomodulation in male rats. To address this critical research gap, the present studies examine the effect of heroin and context-heroin associations on peripheral immune status in female rats. We focus investigations on peripheral nitric oxide (NO) production, a critical pro-inflammatory agent necessary for pathogen resistance. Experiment 1 established that male and female rats have comparably impaired LPS-induced NO production when heroin (1 or 3 mg/kg, s.c.) precedes endotoxin challenge. Subsequently, Experiment 2 demonstrated that female rats express heroin-conditioned immunomodulation under the same experimental parameters that we have previously used in males. Specifically, exposure to heroin-paired stimuli is sufficient to elicit suppression of LPS-induced NO production in female rats. Estrous stage had no effect on the heroin-conditioned immune response. These data are the first to establish that naturally cycling female rats exhibit both heroin-induced and -conditioned immunomodulation. This research helps to inform sex-specific interventions to lessen the negative health consequences associated with heroin use.
Laughing the Politically Incorrect Way: Humor Usage on the 4chan /pol/ Forum
Creators: name: Revis, Lauren
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Journalistic evidence suggests an increasing link between right-wing extremist groups and humor usage. I investigate archives from the “politically incorrect” /pol/ forum on 4chan, an anonymous imageboard website. While not every individual on the /pol/ forum is a right-wing extremist, many have views consistent with right-wing extremist ideology.  I am interested in how humor is used on the /pol/ forum. I use three main methods. 1) Latent Dirichlet Allocation (LDA) topic modeling is being used for 4chan comments from years 2014-2018 to identify common topics and trends. 2) Qualitative text analysis is used to analyze 1,000 comments obtained from 4chan archives for years 2014 and 2018 for humor usage and prevalence of politically incorrect rhetoric (possibly indicating extremist views). 3) Image analysis is used to analyze 650 images from 2014-2018. Analysis of LDA topic modeling shows that most topics center around race, sex, and religion. Racial slurs and expletives are commonly used to discuss these topics. While there are slight differences in what topics are grouped together year by year, overarching themes remain consistent. Qualitative text analysis and image analysis show that ridicule is the most used humor type, and racial minorities - specifically African-Americans - are the most common targets. I explore rhetoric and humor nuances, and conclude that humor is a powerful online tool, used by those on the /pol/ forum to take over symbols in mainstream media and create in-group solidarity.
title: MRI evaluation of breast cancer: imaging strategies for initial diagnosis and post-therapy follow-up
Creators: name: Crivceanschi, Maxim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: MR
subject: Diagnostic procedure
subject: Staging
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To assess the role of breast magnetic resonance imaging (MRI) in the diagnosis and follow-up evaluation of patients with breast...
The measurement of capacitance and inductance in terms of frequency and resistance at radio frequencies
Creators: name: Boner, Charles Paul, 1900-
Publisher: name: The University of Texas at Austin
Year: 1929
Subjects: subject: Electrical measurements
subject: Electric measurements
subject: Capacitance measurement
subject: Inductance measurement
subject: Radio frequencies
subject: Electric resistance
subject: Electric measurements
subject: Capacitance meters
subject: Inductance--Measurement
subject: Radio frequency--Measurement
subject: Electric resistance--Measurement

description: In electrical measurements at audio and radio frequencies the capacitance of condensers and the inductance of coils play a vital part. In fact, if the capacitance or the inductance is accurately known, many other quantities may be accurately determined in terms of these known quantities. It is the purpose of this investigation to devise a general method of measuring capacitance and inductance in terms of the fundamental units of frequency and resistance, which method shall be applicable over a broad range of frequencies. The errors of the system will be discussed, and experimental data will be given to show the application of the method to specific calibrations
title: Cystic Lung Diseases: MDCT findings
Creators: name: Marrone, Gianluca
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cavitation
subject: Computer Applications-General
subject: Computer Applications-3D
subject: CT-High Resolution
subject: CT
subject: Thorax
subject: Respiratory system
subject: Lung
subject: Chronic obstructive airways disease
subject: Cysts

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this review is to present the wide spectrum of common and uncommonlung disease caracterized by cystic...
Treatment-Emergent Macrocytosis as a Predictive Biomarker of Tyrosine Kinase Inhibitor Efficacy in Patients with Solid Malignancies
Creators: name: Tiemann, Andrew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Introduction: There is a paucity of predictive biomarkers of efficacy for tyrosine kinase inhibitors (TKIs), which are cornerstone therapies for solid tumors. Previous studies identified a positive association between treatment-emergent macrocytosis and both progression-free survival (PFS) and overall survival (OS) in sunitinib-treated patients. We aimed to investigate similar associations in additional TKIs used for the treatment of solid tumors.
Methods: This was a single-institution retrospective study that included patients if they were ≥18 years with solid tumor diagnoses (e.g., gastrointestinal stromal tumor, hepatocellular carcinoma, renal cell carcinoma [RCC], and thyroid cancer), and who were treated with axitinib, cabozantinib, imatinib, pazopanib, sorafenib, or sunitinib between 1/1/2010 and 8/15/2017. Patients were excluded if they lacked a baseline and at least one on-treatment mean corpuscular volume (MCV) measurement, or if treatment was in the neoadjuvant/adjuvant setting. Univariate survival analyses were performed using a log-rank test, while Cox Proportional Hazards were used for multivariable survival analyses.
Results: In multivariable analyses of the entire study cohort (n=209), which accounted for the effects of solid tumor diagnosis and TKI selection, on-treatment MCV ≥100 fL and ΔMCV ≥10 fL from baseline were significantly associated with increased OS (P=0.013 and P=0.038, respectively) and PFS (P=0.005 and P=0.011, respectively). In multivariable analyses of the RCC subgroup (n=107), on-treatment MCV ≥100 fL and ΔMCV ≥10 fL from baseline were significantly associated with increased OS (P=0.034 and P=0.038, respectively) and PFS (P=0.0001 and P=0.026). In multivariable analyses of pazopanib-treated patients (n=80), only on-treatment MCV ≥100 fL was associated with increased PFS (P=0.018).
Conclusions: Treatment-emergent macrocytosis predicts TKI treatment efficacy in solid tumors, particularly in RCC and pazopanib-treated patients. These study results provide compelling rationale to pursue future lines of prospective research inquiry clinically to validate these data, and translationally to better understand the molecular mechanisms underlying associations between treatment-emergent macrocytosis and survival.
Laser-based interventions for improving cancer treatment
Creators: name: Nguyen, Hieu Thi Minh
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Nanobubbles
Spectroscopy
Cancer

description: Cancer is the second leading cause of death in the United States, with an estimated 1.8 million new cases and 600,000 deaths annually in 2020. The biggest hurdle in cancer treatment is in completely eradicating all invasive tumor cells, which prevents cancer recurrence and enhances survival rate. Laser based interventions offer unique abilities to sense cancer cells and stimulate biological responses, both of which can be used to enhance cancer treatment. This thesis addresses two interventions aimed at improving cancer survival rate: 1) guidance of surgical resections and 2) systemic immune therapeutics. In the first part of the thesis, we applied non-destructive, fast, and label-free spectroscopy approaches for surgical guidance in skin cancer excision. Our study utilized multimodal spectroscopy with diffuse reflectance, Fluorescent, and Raman to assist tumor margin assessment. Our findings suggested that Raman spectroscopy provided the best diagnosis power among the three techniques and combined modality. We further studied the correlation between Raman measurements and its underlying tissue anatomy. We identified key diagnostic markers to accurately differentiate nonmelanoma cancer from normal skin, highlighting this method's potential in intraoperative tumor margin assessment. In the second part of the thesis, we used laser nanobubbles (bubbles generated around nanoparticles from irradiation with nanosecond pulsed laser radiation) as novel cancer therapy to trigger immunogenic cell death in breast cancer cells. We also applied a new approach to characterize laser nanobubbles' dynamics with optical coherence tomography. We demonstrated for the first time that laser nanobubbles provided a fast, highly specific therapy to eradicate tumor cells and elicit immunogenic cell death, highlighting this approach's potential as a candidate combination strategy for immunotherapy.
Burnout Comparison Among Residents in Different Medical Specialties
Creators: name: Pieper, Hannah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Burnout is an increasing medical phenomenon in the healthcare world and is particularly detrimental to lives and work of medical residents. Despite this, little research is focused on medical residents, who are at the forefront of their careers and prone to high levels of burnout. Therefore, the current study examined associations among burnout, burnout’s relation to perceived stress, social support, gender, age, years in training and specialty type to ultimately aid in future intervention strategies. A random sample of United States Allopathic Medical Doctor (MD) residency training programs led 94 individuals to complete an online survey of the variables in question. Burnout was prevalent among the sample, where 100% of participants reported at least one elevated symptom of burnout and 38.3% of participants reported elevated symptoms of all three burnout components. Burnout was found to be positively associated with perceived stress, and negatively associated with social support and being female. Study findings inform the development of guidelines, recommendations and interventions to educate both residents and program advisors to positively impact the psychosocial experience of medical residents in the future.
Generalized Correntropy for Robust Adaptive Filtering
Creators: name: Chen, Badong
name: Xing, Lei
name: Zhao, Haiquan
name: Zheng, Nanning
name: Príncipe, José C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: As a robust nonlinear similarity measure in kernel space, correntropy has received increasing attention in domains of machine learning and signal processing. In particular, the maximum correntropy criterion (MCC) has recently been successfully applied in robust regression and filtering. The default kernel function in correntropy is the Gaussian kernel, which is, of course, not always the best choice. In this work, we propose a generalized correntropy that adopts the generalized Gaussian density (GGD) function as the kernel (not necessarily a Mercer kernel), and present some important properties. We further propose the generalized maximum correntropy criterion (GMCC), and apply it to adaptive filtering. An adaptive algorithm, called the GMCC algorithm, is derived, and the mean square convergence performance is studied. We show that the proposed algorithm is very stable and can achieve zero probability of divergence (POD). Simulation results confirm the theoretical expectations and demonstrate the desirable performance of the new algorithm.
description: 34 pages, 9 figures, submitted to IEEE Transactions on Signal Processing
Nonprescription Stimulant Use at UNC: Students’ Motives, Experiences, and Guilt
Creators: name: Cook, Carley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The use of prescription stimulants such as Adderall for nonmedical pursuits (NPS) is a growing problem on college campuses (DeSantis et al., 2008). The purposes of this study were to: (1) measure reported NPS among UNC undergraduates; (2) assess relations between NPS and membership in Greek societies; (3) test relations between NPS and binge drinking behavior; (4) measure students’ motivation (academic; social) for NPS and relations between motivation and reported benefits (academic performance enhancement; mood and energy enhancement); and (5) assess student guilt associated with NPS. Over 1200 UNC undergraduate students completed an anonymous online survey. Of initial survey respondents, 143 reported having a prescription for a stimulant medication and therefore were dropped from the study. Among the remaining 1066, 18.9% (N = 201) reported having engaged in NPS. Members of Greek life were three times more likely than their non-affiliated peers to engage in NPS. NPS was also strongly associated with binge drinking behavior. Students overwhelmingly reported that they engaged in NPS for academic purposes (78%) rather than for recreational purposes (12%), or for both reasons (9%). Although experimental research has repeatedly shown that NPS does not enhance cognitive functioning, students reported academic benefits of use. Moreover, as anticipated, students’ motivation for NPS was related to their reported experiences: Students who reported that they engaged in NPS for academic purposes reported stronger academic benefits (e.g., feeling focused; able to study longer) than students who reported engaging in NPS for recreational purposes. Students tended to disagree with guilt items, reporting that they experienced little guilt for NPS. Implications for university personnel who are working to reduce NPS on college campuses are discussed.
title: Depiction ability of solid pulmonary nodules on chest radiography
Creators: name: Minamoto, Naoki
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Observer performance
subject: Computer Applications-3D
subject: CAD
subject: Digital radiography
subject: CT
subject: CAD
subject: Respiratory system
subject: Radiographers
subject: Lung

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Pulmonary adenocarcinoma can be classified based on thin-slice computed tomography (CT) images into the following three groups: ground glass opacity, solid nodule, and part-solid nodule Fig. 1 .Patients with solid nodules show a poor prognosis;...
Automating Game Progression to Empower Users with Disabilities
Creators: name: Megan Rogge
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: With roughly 67% of Americans playing video games [about 211 million people], gaming is an integral part of American culture (Crecente). In the United States, however, “perhaps 2 percent of the population [about 6.3 million people] cannot play computer games because of a disability, and 9 percent [about 28.4 million] can play only at a reduced level” (Garber). Games built for those with disabilities fail in two primary ways: many are designed with educational goals, despite research which shows disabled people want recreational games and they’re designed for very young children, though gaming is most popular in the age range of 18 to 24 (Morris). This thesis stemmed from a desire to create an enjoyable game for this significantly underserved population.
(101947) Richard Wall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The value of breast MRI in preoperative staging of women with primary breast cancer and dense breast tissue
Creators: name: Pietersen, Pia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Diagnostic procedure
subject: MR
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Aim and objectives : Breast conserving therapy (BCT) has gained substantial attention and is a well-established treatment of primary early-stage breast cancer. Long-term survival for patients who underwent BCT is equal to patients treated with...
Controlling spin relaxation with a cavity
Creators: name: Bienfait, A.
name: Pla, J. J.
name: Kubo, Y.
name: Zhou, X.
name: Stern, M.
name: Lo, C. C.
name: Weis, C. D.
name: Schenkel, T.
name: Vion, D.
name: Esteve, D.
name: Morton, J. J. L.
name: Bertet, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Spontaneous emission of radiation is one of the fundamental mechanisms by which an excited quantum system returns to equilibrium. For spins, however, spontaneous emission is generally negligible compared to other non-radiative relaxation processes because of the weak coupling between the magnetic dipole and the electromagnetic field. In 1946, Purcell realized that the spontaneous emission rate can be strongly enhanced by placing the quantum system in a resonant cavity -an effect which has since been used extensively to control the lifetime of atoms and semiconducting heterostructures coupled to microwave or optical cavities, underpinning single-photon sources. Here we report the first application of these ideas to spins in solids. By coupling donor spins in silicon to a superconducting microwave cavity of high quality factor and small mode volume, we reach for the first time the regime where spontaneous emission constitutes the dominant spin relaxation mechanism. The relaxation rate is increased by three orders of magnitude when the spins are tuned to the cavity resonance, showing that energy relaxation can be engineered and controlled on-demand. Our results provide a novel and general way to initialise spin systems into their ground state, with applications in magnetic resonance and quantum information processing. They also demonstrate that, contrary to popular belief, the coupling between the magnetic dipole of a spin and the electromagnetic field can be enhanced up to the point where quantum fluctuations have a dramatic effect on the spin dynamics; as such our work represents an important step towards the coherent magnetic coupling of individual spins to microwave photons.
description: 8 pages, 6 figures, 1 table
(101944) Eliza Ann Wall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The CT fish mouth ampulla sign: A pathognomonic finding in main duct intraductal papillary mucinous neoplasms
Creators: name: Zhang, Ting Ting
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Pancreas
subject: CT
subject: Observer performance
subject: Cysts
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Intraductal papillary mucinous neoplasms (IPMNs) are mucus-secreting cystic lesions arising from the pancreatic duct 1 . These are further characterisedby their location, either arising from the main duct (MD-IPMN), a branch duct (BD-IPMN) or a...
Placental Genomic and Epigenomic Signatures Associated with Infant Birth Weight Highlight Mechanisms Involved in Collagen and Growth Hormone Signaling
Creators: name: Payton, Alexis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Birth weight (BW) represents an important clinical and toxicological measure, indicative of the overall health of the newborn as well as potential risk for later-in-life outcomes. BW can be influenced by many internal and external factors, and is known to be heavily impacted in utero by the health and function of the placenta. However, an aspect that remains understudied is the influence of genomic and epigenomic programming within the placenta on infant BW. To address this gap, we set out to test the hypothesis that genes involved in critical placental cell signaling are associated with infant BW, and are likely regulated, at least in part, through epigenetic mechanisms based on microRNA (miRNA) mediation. This study leveraged a robust dataset based on 390 infants born at extremely low gestational age (ranged 23 to 27 weeks) to evaluate genome-wide expression profiles of both mRNAs and miRNAs in placenta tissues and relate these to infant BW. A total of 339 mRNAs and 262 miRNAs were identified as associated with BW, the majority of which showed similar associations across placentas derived from both male and female infants. The mRNAs were found to be enriched for important biological pathways, including glycoprotein VI (GP6), hormone signaling, and several growth factor pathways, a portion of which are predicted to be regulated by BW-associated miRNAs. These miRNA-regulated pathways highlight key mechanisms potentially linking environmental insults to changes in birth outcomes that may be deleterious to infant and later-in-life health.
title: Fractional anisotropy changes in the subventricular zone in patients with multiple sclerosis
Creators: name: Marti-Bonmati, Luis
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: MR physics
subject: MR-Diffusion/Perfusion
subject: MR
subject: Segmentation
subject: Dementia
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The subventricular zone (SVZ) contains multi-potent neural stem cells and is able to replace neural cells lost during a neurodegenerative process. Some studies have shown microstructural and functional interhemispheric asymmetries of several areas...
Simulated Yeast with Mobile Polarity Sites Is More Sensitive to Pheromone Gradients
Creators: name: Guan, Kaiyun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Cell polarity is the asymmetric distribution of cellular components and molecules. It is crucially important for effective cell motility and other directional functions. However, practically all types of cells were exposed in a large amount of molecular noise which interfered cell polarity, leading the cells to polarize in the wrong direction. Interestingly, though exposed in molecular noise, yeast cells can usually find and polarize in the direction of extracellular pheromone gradients during mating. This study investigated how yeast cells decoded the extracellular pheromone gradient to polarize in the right direction despite the noise. With particle-based simulations, we found that when exposed to a shallow signal gradient, the simulated yeast with mobile polarity sites interpreted the direction of the signal more accurately than the one with static polarity sites. Therefore, the highly dynamic polarity sites could help yeast cells to decode the extracellular pheromone gradient against molecular noise. Future studies will focus on adding more complex signaling pathways to the simulated yeast models to further investigate the effect of mobile polarity sites on yeast polarity establishment.
(101946) Richard Bargeer Wall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.