cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Challenges to biobanking in LMICs during COVID-19: time to reconceptualise research ethics guidance for pandemics and public health emergencies?
Creators: name: Moodley, Keymanthri
name: Singh, Shenuka
name: Cadigan, Rosemary Jean
Publisher: name: BMJ
Year: 2021

description:
Biobanking can promote valuable health research that may lead to significant societal benefits. However, collecting, storing and sharing human samples and data for research purposes present numerous ethical challenges. These challenges are exacerbated when the biobanking efforts aim to facilitate research on public health emergencies and include the sharing of samples and data between low/middle-income countries (LMICs) and high-income countries (HICs). In this article, we explore ethical challenges for COVID-19 biobanking, offering examples from two past infectious disease outbreaks in LMICs where biobanking activities contributed to the perpetuation of global inequities. We focus on how the ethical imperative to promote the common good during public health emergencies can conflict with protecting the interests of biobank participants. We discuss how conducting biobank research under a waiver of informed consent during public health emergencies is ethically permissible, provided guidance is in place to prevent biopiracy and exploitation of vulnerable communities. We also highlight the need for biobank collaborations between LMICs and HICs to promote capacity building and benefit sharing. Finally, we offer guidance to promote the ethical oversight of biobanks and biobank research during the COVID-19 pandemic or other future public health emergencies.
Usage of Dynamic Analysis to Strengthen Control-Flow Analysis
Creators: name: Biswas, Priyam
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: System and network security

description: System programming languages such as C and C++ are ubiquitously used for systems software such as browsers and servers due to their flexibility and high performance. However, this flexibility comes with a price of lack of memory and type safety.
Control-Flow Hijacking (CFH), by taking advantage of the inherent lack of memory and type safety, has become one of the most common attack vectors against C/C++ programs. In such attacks, an attacker attempts to divert the normal control flow of the program to an attacker-controlled location. The most prominent defense against these kind of attacks is Control-Flow Integrity (CFI), which restricts the attack surface by limiting the set of possible targets for each indirect control-flow transfer. However, current analyses for the CFI target sets are highly conservative. Due to the ambiguity and imprecision in the analyses, CFI restricts adversaries to an over-approximation of the possible targets of individual indirect call sites. State-of-the-art CFI approaches fail to protect against special attack classes such as over-writing variadic function arguments. Furthermore, mitigation of control-flow attacks is not explored to its full potential in the context of language boundaries in current literature. Hence, we need effective solution to improve the precision of the CFI approaches as well as strong protection mechanisms against commonly abused corner cases.
We leverage the effectiveness of dynamic analysis in deriving a new approach to efficiently mitigate control-flow hijacking attacks. We present Ancile, a novel mechanism to improve the precision of the CFI mechanism by debloating any extraneous targets from the indirect control-flow transfers. We replaced the traditional static analysis approach for target discovery with seed demonstrated fuzzing. We have evaluated the effectiveness of our proposed mechanism with standard SPEC CPU benchmarks and other popular C and C++ applications.
To ensure complete security of C and C++ programs, we need to shield commonly exploited corners of C/C++ such as variadic functions. We performed extensive case studies to show the prevalence of such functions and their exploits. We also developed a sanitizer, HexVASAN, to effectively type-check and prevent any attack via variadic functions. CFH attacks, by abusing the difference of managed languages and their underlying system languages, are very frequent in client and server side programs. In order to safe-guard the control-flows in language boundaries, we propose a new mechanism, FitJit, to enforce type integrity. Finally, to understand the effectiveness of the dynamic analysis, we present Artemis, a comprehensive study of binary analysis on real world applications.
sj-pdf-1-pms-10.1177_00315125211040448 - Supplemental material for The Roles of Grit and Motivation in Predicting Children’s Leisure-Time Physical Activity: One-Year Effects
Creators: name: Hein, Vello
name: Koka, Andre
name: Tilga, Henri
name: Kalajas-Tilga, Hanna
name: Raudsepp, Lennart
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-pms-10.1177_00315125211040448 for The Roles of Grit and Motivation in Predicting Children’s Leisure-Time Physical Activity: One-Year Effects by Vello Hein, Andre Koka, Henri Tilga, Hanna Kalajas-Tilga and Lennart Raudsepp in Perceptual and Motor Skills
Additional file 1 of Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients
Creators: name: Zeng, Qingze
name: Wang, Yanbo
name: Wang, Shuyue
name: Luo, Xiao
name: Li, Kaicheng
name: Xu, Xiaopei
name: Liu, Xiaocao
name: Hong, Luwei
name: Li, Jixuan
name: Li, Zheyu
name: Zhang, Xinyi
name: Zhong, Siyan
name: Liu, Zhirong
name: Huang, Peiyu
name: Chen, Yanxing
name: Zhang, Minming
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Hematology

description: Supplementary Material 1.
sj-pdf-2-ecl-10.1177_14687984211041389 - Supplemental material for Trilingualism and reading difficulty in a third (school) language: A case study of an at-risk child in French immersion
Creators: name: Petrescu, Maria Claudia
name: Helms-Park, Rena
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-pdf-2-ecl-10.1177_14687984211041389 for Trilingualism and reading difficulty in a third (school) language: A case study of an at-risk child in French immersion by Maria Claudia Petrescu and Rena Helms-Park in Journal of Early Childhood Literacy
Additional file 1 of Mapping of infection prevention and control education and training in some countries of the World Health Organization’s Eastern Mediterranean Region: current situation and future needs
Creators: name: Moghnieh, Rima
name: Al-Maani, Amal Saif
name: Berro, Jana
name: Ibrahim, Nour
name: Attieh, Rana
name: Abdallah, Dania
name: Al-Ajmi, Jameela
name: Hamdani, Dhouha
name: Abdulrazzaq, Najiba
name: Omar, Abeer
name: Al-Khawaja, Safa
name: Al-Abadla, Rami
name: Al-Ratrout, Salam
name: Gharaibeh, Mohammad
name: Abdelrahim, Zakaria
name: Azrag, Hiba
name: Amiri, Karima Mayar
name: Berry, Atika
name: Hagali, Bashar
name: Kadhim, Jamal
name: Al-Shami, Huda
name: Khan, Mumtaz Ali
name: Husni, Roula
name: Heweidy, Iman
name: Zayed, Bassim
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
title: Social Entrepreneurship: Sociality, Ethics, and Politics
Creators: name: Bandinelli, Carolina
Publisher: name: Goldsmiths, University of London
Year: 2017
Subjects: subject: social entrepreneurship, social innovation, neoliberalism, entrepreneur of the self, subjectivity, network sociality, post-politics, individualism, ethnography

description: Social entrepreneurship is a growing cultural phenomenon that involves a variety of actors – politicians, academics, business men and women, private citizens - across a range of interconnected fields – e.g. social work, sustainable development, the sharing economy and technological innovation. Notwithstanding its heterogeneous manifestations, social entrepreneurship is characterised by the attempt to re-embed social and ethical dimensions within the individualised conduct of the entrepreneur of the self. The aim of this dissertation is to investigate how this process is thought of and negotiated on a subjective level by young social entrepreneurs in London and Milan. Based on an understanding of social entrepreneurs as individuals who perceive work as a means for self-expression, I contextualise this enquiry within the field of cultural studies on the changing nature of labour in neoliberal societies. This thesis draws on an 18-month period of multi-sited and reflexive fieldwork that involved recorded interviews, participant observation and action research. Combining thick ethnographic descriptions and theoretical analysis, I focus on social entrepreneurs’ understanding of sociality, ethics, and politics, in so far as they are intertwined with the discourses and practices of entrepreneurship. My argument develops in three stages: to begin with, I show that social entrepreneurs engage in opportunistic and compulsory sociality; then, I dwell on social entrepreneurs’ individualised form of ethics; finally, I contend that social entrepreneurs enact and embody a post-political subjectivity. This subjectivity is defined by discourses and actions whose scope and significance are restrained within the bounds of individuals’ experience and influence. What remains inevitably excluded from this conception of politics is the possibility to of formulating a structural analysis of social issues. In this respect, my research may be regarded as a study on how the neoliberal subject par excellence – the entrepreneur of the self – attempts to retrieve and reclaim her political and ethical agency, and what the implications and limits of this endeavour are.
Preparative Mass Spectrometry: Instrumentation and Applications
Creators: name: Su, Pei
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Analytical spectrometry

description: Ion soft landing is a preparative mass spectrometry technique that enables intact deposition of polyatomic ions onto surfaces. The ability to select ions with well-defined mass, charge, and kinetic energy, along with precise control over size, shape, and position of the ion beam in the deposition process distinguishes ion soft landing from traditional synthetic and surface preparation approaches. A wide range of projectile ions including molecular ions, non-covalent complexes, clusters, and ionic fragments generated in the gas phase have been used in soft-landing studies to address both the fundamental questions related to ion-surface interactions and enable applications of hyperthermal beams. Since the first soft landing instrument was implemented by Cooks and co-workers in 1977, significant advances have been achieved in preparative mass spectrometry instrumentation. Current instrument development efforts are focused on obtaining high ion currents, increasing the experimental throughput, and developing capabilities for layer-by-layer deposition. In chapter 2 and 3, two novel instrumentation approaches are introduced, which improve the ion flux and experimental throughput of ion soft landing research. In particular, soft landing of ions of both polarities enables the bottom-up construction of ionic materials. Meanwhile, a rotating wall mass analyzer substantially increases the mass range of mass-selective deposition and disperses multiple species on the same surface thereby increasing the experimental throughput. These instrumentation developments open up the opportunities to explore research topics in the field of catalysis, energy storage and production, biology, and quantum sciences. In chapter 4, I describe a novel in situ spectroelectrochemistry approach for studying structural changes of electroactive species during electrochemical processes. In these experiments, ion soft landing is used to prepare well-defined ions at electrochemical interfaces. In addition, understanding of the gas-phase properties of cluster ions is important for their application in ion soft landing research. Ions can be prepared in the proper physical and chemical state via gas-phase chemistry approaches, and the favorable properties and reactivities of ions can thereby be harnessed using ion soft landing. In chapter 5 and 6, gas phase properties of host-guest complexes of cyclodextrins and polyoxometalates and molybdenum halide clusters are discussed.
title: A developmental cognitive neuroscience approach to the investigation of conduct problems and classroom behaviour for learning
Creators: name: Smith, Hannah
Publisher: name: Goldsmiths, University of London
Year: 2017
Subjects: subject: conduct problems, conduct disorder, callous-unemotional traits, educational neuroscience, executive functions, emotion regulation, classroom intervention, student-teacher relationship

description: With a high prevalence of conduct problems (CP) in school-aged children, effective interventions for these youths are of great importance. This thesis considers CP in the context of the classroom, including examinations of executive function (EF) and emotion-related skills; the development and evaluation of a classroom-based intervention to improve behaviours for learning; and an EEG investigation of cognitive control and emotion regulation (ER). The heterogeneous nature of CP is considered throughout, with an examination of the callous-unemotional (CU) traits subtype.

In two experimental studies, pupils with CP (with and without CU traits) were found to have deficits in EF and emotion-related skills. Low behavioural and academic self-perceptions and poor student-teacher relationships (STR) were also identified. For the first time, emotion lability/negativity was identified as a mechanism through which CP is associated with student-teacher conflict. A systematic review of intervention outcomes for CU traits indicated generally poorer outcomes for these youths, but demonstrated the potential for behaviour change. Based on this work, a cognitive neuroscience informed intervention for mainstream pupils with CP was developed and evaluated. The intervention yielded mixed results, with poor fidelity from teaching staff possibly accounting for this. Finally, a direct measure of cognitive and emotional control was addressed through a pilot study with adults, using an EEG emotion-induction go/no-go paradigm. A distinct N2 component was found, providing support for this tool as a measure of ER. Self-reported EF and ER were not associated with the N2 response; possible reasons for this are discussed.

The results in this thesis advance our understanding of CP in the school context, provide support for the utility of the CU traits distinction, and examine the effectiveness of intervention approaches for these pupils. Furthermore, measurement issues in EF and ER research are highlighted and related to a novel EEG measurement tool.
title: The subprime middle class: precarious labour, mortgage default, and activism among Ecuadorian migrants in Barcelona
Creators: name: Suarez, Maka
Publisher: name: Goldsmiths, University of London
Year: 2017
Subjects: subject: mortgage debt, social movements, Spain, PAH, Ecuadorian migrant workers

description: This dissertation is an ethnographic account of Ecuadorian migrant workers in Barcelona and their aspirations for upward mobility. I take home buying practices in Ecuador and Spain as an ethnographic pivot from which to observe how these aspirations are actualized but also redefined. Through remittance-bought homes or through subprime mortgage loans, Ecuadorian migrants aspired to ‘move forward’. Years later they found themselves unemployed, overly indebted, and foreclosed. The mortgage default processes documented in this dissertation make evident that Ecuadorian migrants were all along pigeonholed into low-skilled jobs, substandard working permits, peripheral neighbourhoods, and expensive mortgage loans. This, I claim, evidences that the only form of middle class they were allowed to aspire to was a subprime middle class.

Placed between the swings of two ‘financial crises’ Ecuadorian migrants are in a unique position to witness how ‘financial capitalism’ is made. How it emerges from concrete forms of livelihood in which precarious labour and predatory lending are enmeshed with a wide range of social relationships. By following people’s own understandings of upward mobility, or what they referred to as ‘moving forward’, I document how this everyday notion intertwines with transnational relations and care practices, labour and citizenship statuses, mortgage indebtedness and default. 

This dissertation provides a bottom-up view of the 2008 financial ‘crisis’ from a little explored vantage point, that of subprime migrant debtors. It also offers a view into new forms of social organization against indebtedness. Unemployed and foreclosed Ecuadorians turned to housing activism joining the PAH, Spain’s fastest growing housing social movement. By pooling mortgage debts and contesting over-indebtedness I claim the PAH effectively produced a bottom-up debt jubilee. It also became a space to make sense of economic hardship and default, create new knowledge about indebtedness, and make room for hope and the reconstruction of social relationships.
Supplemental Material, sj-pdf-1-apc-10.1177_23742895211040208 - The Relationship Between Medical School–Based Pathology Departments and Affiliated Forensic Pathology Training Sites
Creators: name: Bailey, David N.
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental Material, sj-pdf-1-apc-10.1177_23742895211040208 for The Relationship Between Medical School–Based Pathology Departments and Affiliated Forensic Pathology Training Sites by David N. Bailey in Academic Pathology
Evaluation of Contaminants of Emerging Concern and Their Transformation Products in Water
Creators: name: Hilawie Belay, Masho
Publisher: name: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2022
Subjects: subject: Contaminants of emerging concern; Experimental design techniques; HPLC-MS/MS; HPLC-HRMS; Method development and validation; Non-target screening methods; Pharmaceuticals; Photodegradation products; River water; UHPLC-MS/MS; Wastewater; Water
subject: Contaminants of emerging concern
subject: Experimental design techniques
subject: HPLC-MS/MS
subject: HPLC-HRMS
subject: Method development and validation
subject: Non-target screening methods
subject: Pharmaceuticals
subject: Photodegradation products
subject: River water
subject: UHPLC-MS/MS
subject: Wastewater
subject: Water

description: In recent decades, pharmaceuticals have emerged as a significant new group of contaminants of emerging concern (CECs). Due to their inefficient removal by conventional wastewater treatment plants (WWTPs), a significant amount of these drugs enters the aquatic environment via municipal sewage systems. Despite the recent consumption trend, which is projected to continue in the future due to rising incidence of health issues requiring pharmaceutical treatment, little is known about the occurrence and fate of many pharmaceuticals in the aquatic environment. This thesis studied ten pharmaceuticals for which there is a considerable lack of data concerning their occurrence and fate in the aquatic environment. Thus, new analytical methods have been developed and validated for the determination of CECs and their transformation products (TPs). As a result, nine new TPs of two drugs (irinotecan and aliskiren) in water have been identified using UHPLC and mass spectrometry (QTRAP and Orbitrap). Moreover, a fully automated online SPE LC MS/MS method was validated for the determination ten pharmaceuticals in wastewater, allowing ultra-trace analysis. In addition to these targeted methods, the potential of LC-HRMS was explored for non-target screening of wastewater and surface waters from Greece, France, and Italy. A total of 264 environmental contaminants were identified and the findings were deposited into the NORMAN databases using the Suspect List Exchange and Digital Sample Freezing Platform. Finally, experimental design (DOE) techniques were applied to optimize and study the robustness of CECs’ abatement processes. Thus, the effects of various factors were studied on the solar photodegradation of irinotecan and the UV photocatalytic degradation of maprotiline. Consequently, WWTP operational guidelines have been established by identifying the factors that have no effect, or those that must be strictly controlled, as even tiny alterations can result in decreased efficiency.
Analyzing Non-Cognitive Predictors of Secondary and Postsecondary Academic Achievement
Creators: name: Cermak, Brianna Joy
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Educational psychology

description: A secondary data analysis was conducted using the High School Longitudinal Study of 2009 (HSLS:09) provided by the National Center for Education Statistics to assess the relationships between academic performance indicators (high school GPA, high school mathematics achievement, and college enrollment) and perceptions of utility value, self-efficacy, effort cost, school engagement, and intelligence theories (N = 5,789). Four data collection phases occurredduring HSLS:09-- 9th grade fall semester (BY), 11th grade spring semester (F1), undergraduate update in summer 2013 (U13), and a second follow-up in winter 2016 (F2).
The domain specificity and stability over time of each motivational construct was also assessed. Evaluating the domain specificity of a motivational construct helps us further understand the theoretical construction and appropriate measurement of these constructs. Motivationalconstructs that are more stable over time are more likely to be more effective long-term predictors of academic performance. Paired t-tests were conducted to evaluate the domain specificity and stability of each motivational construct. Regression models were utilized toassess motivational constructs’ ability to predict academic performance.
Effort cost was the only motivational construct that was not domain specific (t = 1.79, p = 0.07). Science self-efficacy was the only motivational construct determined to be stable over time (t = 1.19, p = 0.24). School engagement, BY science efficacy, mathematics effort, and F1 scienceutility were significant predictors of increased academic performance for all academic performance indicators.
Additional file 1 of CCDC25 suppresses clear cell renal cell carcinoma progression by LATS1/YAP-mediated regulation of the hippo pathway
Creators: name: Tan, Hongpei
name: Liu, Jiahao
name: Li, Yanan
name: Mi, Ze
name: Liu, Baiying
name: Rong, Pengfei
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: 1. Supplementary Methods. 2. Uncropped gel and blot images of western blot.
sj-pdf-2-inq-10.1177_00469580211036283 – Supplemental Material for Impact of Pharmacist-Led Interventions on Diabetes Management at a Community Pharmacy in Pakistan: A Randomized Controlled Trial
Creators: name: Abubakar, Muhammad
name: Atif, Muhammad
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-2-inq-10.1177_00469580211036283 for Impact of Pharmacist-Led Interventions on Diabetes Management at a Community Pharmacy in Pakistan: A Randomized Controlled Trial by Muhammad Abubakar and Muhammad Atif in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
title: The Sound System of the State: Sonic Strategies for Political Critique at the Borders of Palestine-Israel
Creators: name: Tlalim, Tom
Publisher: name: Goldsmiths, University of London
Year: 2017
Subjects: subject: Installation, Activism, Human Rights, Digital, Data, Sound, Studies, Film, Power, Art, Media, Borders, Palestine, Israel, Practice based research, Digital, Community, Ontology, Vibratiology, Conflict, War, Listening, Performativity, Territorialization

description: This thesis examines political processes in Palestine-Israel by listening to their sound. While stagnating peace negotiations have been dominated by visual sensibility, it is argued that considering sonic sensibility could contribute to the re-examination of current border regimes. Sound and listening are examined as both the objects of study and the means of investigation, from their deployment by states for suppression and war to their use in power diffusion, resistance and critique. The central question is how the aural sense is deployed in both the assertion and critique of political power in Palestine-Israel – that is, what are the strategies, techniques, tools and approaches used, and how do they operate in claims for power, and in the undermining of such claims?

The dynamics of sound inform the methodology of this practice-based thesis, which consists of a written text and a series of artworks produced during the research. The written structure is organised around a set of case studies and artworks by the author and other artists. The combination of art practice, theory and case studies informs and influences the theory involved, while the theory influences the artwork produced. As a consequence, a grounded theory of aural politics emerges, where power and dominance may be both asserted and diffused sonically. The theoretical framework draws on postcolonial and conflict studies (Balibar, Weizman, Said, Mbembe, Mignolo) and on sound studies (Barthes, Attali, Chion, Schaffer, Sterne, Erlmann, LaBelle, Henriques, Goodman, among others). 

Examining the problematics of Palestine-Israel through sound, the thesis makes a threefold contribution by 1) contributing to sound studies and the understanding of the sonic as a political medium, supplementing existing visual and discursive approaches to conflict studies; 2) applying a sonic analysis to conflict and power struggles in Palestine-Israel; and 3) making an artistic contribution through audio chapters and sound art produced during the study which draw on and impact debates on Palestine-Israel. This thesis therefore contributes to our understanding of the Palestine-Israel conflict, to the analysis of sound as a medium for social exchange and for the critique of power, and to the potential of sound to contribute to political processes.
sj-pdf-3-inq-10.1177_00469580211036283 – Supplemental Material for Impact of Pharmacist-Led Interventions on Diabetes Management at a Community Pharmacy in Pakistan: A Randomized Controlled Trial
Creators: name: Abubakar, Muhammad
name: Atif, Muhammad
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-3-inq-10.1177_00469580211036283 for Impact of Pharmacist-Led Interventions on Diabetes Management at a Community Pharmacy in Pakistan: A Randomized Controlled Trial by Muhammad Abubakar and Muhammad Atif in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
Alla ricerca delle valli perdute. Conoscenze locali e pratiche d’uso in alta montagna tra XVII e XVIII secolo, uno studio interdisciplinare sulle Alpi Nord-occidentali
Creators: name: Garoglio, Eugenio
Publisher: name: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2023
Subjects: subject: Montagna; Alpinismo; Ascensioni; Storia Territoriale; Risorse alpine; Fauna alpina; Miniere alpine; Pascoli; Commercio alpino; Guerra di Montagna; Valli di Lanzo; Caccia; Alpi occidentali; Popolazione; Rapporto; Valle; Ambiente; Rouzier; Militare; Documento; Piemonte; Alta Quota; Confini; Commercio; Contrabbando; Estrazioni; Archivi Locali; Sabaudo; Frontiera
subject: Montagna
subject: Alpinismo
subject: Ascensioni
subject: Storia Territoriale
subject: Risorse alpine
subject: Fauna alpina
subject: Miniere alpine
subject: Pascoli
subject: Commercio alpino
subject: Guerra di Montagna
subject: Valli di Lanzo
subject: Caccia
subject: Alpi occidentali
subject: Popolazione
subject: Rapporto
subject: Valle
subject: Ambiente
subject: Rouzier
subject: Militare
subject: Documento
subject: Piemonte
subject: Alta Quota
subject: Confini
subject: Commercio
subject: Contrabbando
subject: Estrazioni
subject: Archivi Locali
subject: Sabaudo
subject: Frontiera

description: Lo studio si focalizza sull’uso dell’alta montagna nel settore alpino occidentale in una prospettiva diacronica che abbraccia i secoli XVII e XVIII. Il soggetto privilegiato di questo lavoro è il rapporto tra le popolazioni alpine e l’ambiente dell’alta montagna esaminato nelle diverse declinazioni delle attività di valle. Nella prima parte si sono ricercate tracce di questi saperi nei documenti di origine militare, tra essi ampio respiro è stato dato alle memorie dell’ufficiale sabaudo J. B. Rouzier riguardo la frontiera occidentale del Piemonte. Nella seconda parte ci si è occupati di un’area più circoscritta, le Valli di Lanzo, di cui si sono ricercate fonti documentali all’interno degli archivi locali capaci di ricostruire alcune delle attività condotte in alta quota; tra esse le estrazioni minerarie, le pratiche di pascolo, la difesa dei confini, il commercio e il contrabbando in quota, la caccia e i rituali religiosi legati ai monti. La tesi ambisce a dimostrare come l’ambiente alpino d’alta quota fosse conosciuto, sfruttato e percorso dalle popolazioni locali nei secoli appena precedenti la nascita ufficiale dell’alpinismo.
Sustainable Autonomous Solar UAV with Distributed Propulsion System
Creators: name: Liu, Shupeng
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Aircraft performance and flight control systems

description: Solar-powered Unmanned Aerial Vehicles (UAVs) solve the problem of loiter time as aircrafts can fly as long as sufficient illumination and reserve battery power is available. However, Solar-powered UAVs still face the problem of excessive wingspan to increase solar capture area, which detracts from maneuverability and portability. As a result, a feature of merit for solar UAVs has emerged that strives to reduce the wingspan of such UAVs. The purpose of this project is to improve energy use efficiency by applying a distributed propulsion system to reduce the wingspan of solar-powered UAVs and increase payload. The research focuses on optimizing a new design analysis method applied to the distributed propulsion system and further employs the novel application of solar arrays on both top and bottom of the wings. The design methodology will result in a 2.1-meter wingspan, which is the shortest at 2020, for a 24-hour duration solar-powered UAV.
sj-docx-1-smm-10.1177_09622802211037073 - Supplemental material for Sample sizes for cluster-randomised trials with continuous outcomes: Accounting for uncertainty in a single intra-cluster correlation estimate
Creators: name: Lewis, Jen
name: Julious, Steven A
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-smm-10.1177_09622802211037073 for Sample sizes for cluster-randomised trials with continuous outcomes: Accounting for uncertainty in a single intra-cluster correlation estimate by Jen Lewis and Steven A Julious in Statistical Methods in Medical Research
Investigating human metabolome in infectious disease, microbiota and cancer
Creators: name: Amede, Elia
Publisher: name: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2023
Subjects: subject: Metabololomics; Microbiota; COVID-19; Cancer
subject: Metabololomics
subject: Microbiota
subject: COVID-19
subject: Cancer

description: My research activities focused on the use of metabolomics methods to study diseases. GCxGC-TOFMS was used to analyze plasma, serum, feces, and tissues to characterize their metabolome and biochemistry. The effect of SARS-CoV-2 on human metabolome was investigated. At first, a metabolomic studies was performed on plasma samples. The objective was to identify molecules and pathways associated with the host response to SARS-CoV-2. The analysis revealed a significant alteration in the metabolome composition in infected patients and some potential biomarker and pathways involved in the disease. Then a metabolomic study was carried out on EBC from COVID-19 patients. The study aims to develop new non-invasive diagnostic tools. The results underlined a metabolomic signature linked with COVID-19 infection and some potential diagnostic markers. The last study performed on this infection studied the metabolic phenotype that may protect or predispose individuals from SARS-CoV-2 infection. The aim was to identify molecules associated with predisposition and protection against the virus. The results outlined a set of potentially protective metabolites. The development and validation of a new double extraction methods for feces, adenomatous polyp’s surfaces, and cancer tissues was performed. The first method concern fecal samples, and was used to investigate the impact of a Mediterranean Diet intervention on the gut microbiota of pediatric obese patients. The outcomes show an alteration of metabolites related to the consumption of healthier food. Then the second method aim to study microbiota-produced small molecules on adenomatous polyps surface. Metabolomics results showed that the aggressiveness grade of cancer was related to the abundances of some SCFA. Finally, a method to investigate the biochemistry of sarcoma cancer through the analysis of cancer and healthy tissues from patients was developed. The results showed different metabolic signature related with sarcoma.
Additional file 1 of Birth weight and premature ovarian insufficiency: a systematic review and meta-analysis
Creators: name: Jiang, Chengyang
name: Gao, Tongqing
name: Wang, Yuwei
name: Yang, Wenqiang
name: Huang, Huan
name: Li, Yushan
name: Yang, Xinghai
Publisher: name: figshare
Year: 2024
Subjects: Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1
sj-docx-1-jpc-10.1177_21501327211044058 – Supplemental material for The Care-of-the-Elderly Health Guide
Creators: name: Triscott, Jean A.C.
name: Dobbs, Bonnie
name: Charles, Lesley
name: Huang, James
name: Moores, David
name: Tian, Peter George Jaminal
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-jpc-10.1177_21501327211044058 for The Care-of-the-Elderly Health Guide by Jean A.C. Triscott, Bonnie Dobbs, Lesley Charles, James Huang, David Moores and Peter George Jaminal Tian in Journal of Primary Care & Community Health
Study of occupational and environmental exposure to asbestos through linkage methods and spatial analysis
Creators: name: Airoldi, Chiara
Publisher: name: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2023
Subjects: subject: asbestos; mesothelioma; occupational and environmental exposure; linkage method; spatial analysis
subject: asbestos
subject: mesothelioma
subject: occupational and environmental exposure
subject: linkage method
subject: spatial analysis

description: INTRODUCTION The identification and monitoring of cancers caused by occupational or environmental exposure to asbestos is an important aspect of public health The first aim of the study was to identify patients with a cancer different from malignant mesothelioma (MM), who worked in firm with at least possible occupational asbestos exposure [BRIC]. The second aim was to assess the spatial variation of MM risk in the area of Casale Monferrato and to detect clustering associated to the secondary sources of asbestos [LATENT]. METHODS For the first project [BRIC], we considered the registries of MM from seven Italian Regions, while the other cancer cases (OCM) were available only for two. As ReNaM and OCM could not be merged directly due the absence of a linkage key, different linkage methods were implemented. For the second project [LATENT], we used data from a population-based case–control study conducted in Casale Monferrato between 2001 and 2006. Demographic and occupational data along with residential information were recorded. The spatial variation in disease risk was mapped and adjusted logistic models were applied. RESULTS In BRIC, we included 4134 cases of MM recorded in ReNaM, corresponding to 12801 occupational records. The linkage procedure allowed to identify 2606 firms with asbestos exposure. Of 35010 cases included in the OCM system, 6546 (18.7%) worked in these firms. One hundred ninety-six cases and 322 controls were included in the analyses of LATENT project. The plot showed a well-defined peak of MM incidence near the asbestos cement factory when large bandwidths were used. However, changing parameters, several peaks of increased risk were reported. A constant trend of decreasing Odds Ratio with increasing distance was observed, with estimates of 10.9 and 10.48 for 0-5 km and 5-10 km, respectively (reference >15 km). CONCLUSION The project has allowed to deepen the study of the effect of two types of asbestos exposure: occupational and environmental.
A COMPUTATIONAL APPROACH TO EXPLORING THE IMPACT OF CHROMATIN ON DNA DAMAGE, REPAIR, AND MUTAGENESIS
Creators: name: Morledge-Hampton, Benjamin S.
Publisher: name: Washington State University
Year: 2024
Subjects: Chromatin
Computational
DNA Damage
Nucleosomes
Biology
DNA Repair
Mutagenesis

description: Maintaining genome integrity is vital to the survival and proliferation of all life. DNA is constantly exposed to a variety of damaging agents, both endogenous (e.g., radical oxygen species) and exogenous (e.g., ultraviolet (UV) light from the sun or benzo[a]pyrene from cigarette smoke). Repair mechanisms such as mismatch repair (MMR) and nucleotide excision repair (NER) are responsible for fixing this damage which, left unrepaired, can lead to mutagenesis and cancer. While much is known about the interplay between DNA damage and repair that leads to mutations, the genomes of higher eukaryotes are highly dynamic and interact with a myriad of DNA-binding proteins such as histones and transcription factors. As a result, the extent to which DNA damage and repair vary throughout the genome is not fully understood. To elucidate the impact of nucleosomes on mutagenesis, we developed mutperiod, a software package which quantifies periodic trends about nucleosomes, and used it to link MMR activity to nucleosomal mutation patterns in esophageal cancer. We also leveraged this software to explore damage and repair patterns for UV-induced cyclobutane pyrimidine dimers (CPDs) in Drosophila cells, which revealed that nucleosome spacing varies across different chromatin domains, significantly impacting CPD repair. This analysis leveraged excision-repair sequencing (XR-seq) data which mapped NER activity throughout the genome, albeit without precise lesion positioning. To increase this precision, we developed an analysis pipeline utilizing heightened cytosine deamination rates in CPDs to locate damaged bases in XR-seq reads at single nucleotide resolution. By applying this pipeline to existing XR-seq data, we found evidence for an HYV (not guanine; pyrimidine; not thymine) sequence bias at the 5’ NER incision location and coupling between the two NER incision events during repair in eukaryotic cells. Finally, by analyzing repair and damage data for the primary DNA adduct in lung cancer, benzo[a]pyrene diol epoxide (BPDE), we showed that a preference for damage formation in unbound DNA establishes the unusual mutation enrichment at linker regions in lung cancer. Together, these results contribute to our understanding of how DNA damage and repair are modulated by chromatin and provide computational methods for the continued study of these interactions.
Let it Go: A Critical Comparative Analysis of the Modern-Day Female Protagonist Based on Disney's Frozen and Frozen II
Creators: name: Scheffer-Wentz, Hannah G
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Communication studies
Media studies

description: This thesis is a comparative content analysis of the modern-day female protagonists represented in Disney’s newest and highest grossing film series, Frozen and Frozen II. As one of the few major media companies that have captivated a global audience, Disney has supplied fantasy princess narratives for over 80 years. With the new addition of Disney+, classic and modern princess films alike are now available for instant streaming. As the sample represents the newest films in the post-transitional wave of the Disney Princess line, this study aims to reveal what messages are being projected to young, impressionable audiences around the world. Between the third wave of feminism and rising conversations of gender roles and communication, Disney Princess films in particular have been the subject of many conversations and criticisms. Using content analysis methodology with each film, the data identifies gender roles, conflict resolution, and common themes between the six main characters: Elsa, Anna, Kristoff, Olaf, the King, and the Queen.
Best practices and organizational models for advanced management of older people in hospital and primary care settings: a translational approach to fall prevention
Creators: name: Campani, Daiana
Publisher: name: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2023
Subjects: subject: Best practices; organizational models; healthcare; nursing; fall prevention; older people; geriatrics; aging; primary care
subject: Best practices
subject: organizational models
subject: healthcare
subject: nursing
subject: fall prevention
subject: older people
subject: geriatrics
subject: aging
subject: primary care

description: Worldwide, aging populations are driving the adoption of new organizational and health-care models. Particularly needed are hospital and primary care organizational models that positively influence health outcomes and clarification on the best practices for preventing falls and the loss of physical function among older people living at home. The aim is to explore new organizational models for the advanced management of older people in hospital and in primary care settings and to implement best practices for reducing falls. The first chapter presents general considerations and provides a summary of the rationale behind the study design. The second chapter contains an explanation of the project’s concept in more detail and an in-depth discussion of the thesis topics. The third chapter introduces an innovative hospital model for intensive care in the geriatric setting, and the fourth chapter presents an application of that model. The fifth chapter presents the results of the application of the model at the primary care level in which the setting has been shifted from the hospital to the patients’ homes. The sixth chapter introduces two examples of how the evidence discussed here can be applied in practice. Preliminary results are contained in the meta-analysis in chapter seven. The eighth and ninth chapters present best practices for fall prevention in the elderly, and chapter ten addresses the challenge of fall prevention in the home setting through the use of technology that records falls and monitors the patient over time. This tool, which has been validated across borders, is the topic of chapter eleven. In chapter twelve, the general research pathway and additional considerations are discussed. Although studies are still ongoing and, therefore, conclusive inferences are not possible, preliminary results on the use of the organizational healthcare model and best practices are promising. Further studies are needed to investigate the impact in terms of the quality of clinical and organizational care, as well as patient satisfaction and outcome
Ca2+ related mechanisms of cellular dysfunction in neurodegeneration
Creators: name: Dematteis, Giulia
Publisher: name: Università degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2024
Subjects: subject: Calcium signaling
subject: astrocytes
subject: calcineurin
subject: mitochondria-endoplasmic reticulum contact sites
subject: neurodegeneration
subject: Calcium signaling; astrocytes, calcineurin, mitochondria-endoplasmic reticulum contact sites, neurodegeneration

description: Calcium is a pleiotropic intracellular messenger regulating mitochondrial bioenergetics and proteostasis, both altered in Alzheimer’s disease (AD). In my PhD project I have studied the cause-effect relationships between calcium dishonesties and cellular dysfunction in astrocytes. In this context I investigated the discrepancy, described in AD astrocytes, between deficient mitochondrial calcium uptake and increased ER-mitochondria interaction, which in principle should promote ER-mitochondrial calcium transfer. To solve this issue, I investigated the correlation between ER-mitochondria distances and efficiency of calcium transfer: I designed a palette of ER-mitochondria linkers, discovering that ER-mitochondria calcium transfer is strongly inhibited at 10nm distances, and is strongly potentiated at 20nm, explaining why increased ER-mitochondria interaction at 8-10nm, in AD astrocytes, results in reduced mitochondrial calcium uptake. Another aspect of my PhD thesis is the investigation of Calcineurin (CaN) role in both physiology of astrocytes and AD related astrocytes dysfunction. In astrocytes, eIF2α-mediated protein synthesis and proteasomal degradation are under CaN control. While, in and AD mice model, deletion of astroglial CaN displayed a protective effect, reducing memory impairment, aβ plaques deposition and tau hyper-phosphorylation. These results indicate that CaN, under pathological conditions can drive pathology progression. I demonstrated that ER-mitochondria interaction and calcineurin represents promising therapeutic targets to mitigate AD related astroglial pathophysiology, given the importance of astrocytes for brain functions further studies are warranted to elucidate mechanisms of these dysfunctions.