cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ROLE OF PHOSPHORYLATION IN THE LINKER 2 REGION OF POLYPYRIMIDINE TRACT BINDING PROTEIN 2
Creators: name: Cuellar, Andres D.
Publisher: name: Zenodo
Year: 2023
Subjects: PTBP
alternative splicing
post translational modifications
phosphorylation
EMSA

description: Polypyrimidine Tract Binding Proteins PTBP1 and PTBP2 are paralogous RNA binding proteins that alternatively splice exons during pre-mRNA processing. The two proteins share high primary sequence identity and similar tertiary structure but have tissue specific expression patterns and regulate overlapping and distinct sets of target exons. How related proteins in a gene family can exert different splicing activities on regulated exons is not understood. Under splicing assay conditions PTBP2 Linker 2 region’s T298 and S308 are phosphorylated post translationally. The corresponding amino acids in PTBP1 are those that cannot undergo phosphorylation. A comparison of PTBP1 and 2 amino acid sequences in the Linker 2 region showed conservation of the corresponding residues across several jawed vertebrates suggesting amino acid changes between the paralogs may have been acquired for functional specialization. Furthermore, a chimera containing PTBP1 Linker 2 region in an otherwise PTBP2 protein showed exon repression like that of wild type PTBP1. We evaluated the hypothesis that PTBP2 phosphorylation at T298 and S308 affects the RNA binding and splicing activity of PTBP2. To evaluate this, we created alanine and phosphomimic single and double mutants of T298 and S308. We assayed their binding affinity via Electrophoretic Mobility Shift Assays (EMSA) to two RNA substrates. We show that double phosphate mimic PTBP2T298DS308D shows significantly higher binding affinity (76 ± 6.0 nM) than PTBP2 wild type (104 ± 7.1 nM) to a region downstream of a regulated exon. Collectively, our studies support a role for phosphorylation in PTBP2 RNA binding affinity.
Sistema de apresentação de dados da doença de Parkinson
Creators: name: Costa, Lucas Moreira.
Publisher: name: Zenodo
Year: 2022
Subjects: visualização de dados
doença de Parkinson
tecnologias vestíveis
sistema web

description: Com o avanço da tecnologia e o ganho de popularidade da internet das coisas, do inglês Internet of Thing (IoT), o uso de sensores inerciais para o acompanhamento do andamento dos sintomas da doença de Parkinson (DP) e a avaliação do tratamento medicamentoso, tem se tornado objeto de estudo de muitos pesquisadores. No entanto, percebe-se uma falta de estudos que visam construir sistemas que permitam uma melhor visualização dos dados coletados por esses sensores inerciais, e consequentemente, a análise das coletas feitas sofre com a falta de ferramentas que auxiliem este processo. Nesse cenário, o presente trabalho teve foco na construção de um painel web para visualização de dados coletados por sensores inerciais de indivíduos acometidos pela DP. Para isso, foi feita inicialmente uma revisão da literatura para a contextualização de como estavam o andamento das pesquisas e estudos a respeito do uso de sensores inercias aplicados à DP. Em seguida, foi construído um protótipo do módulo que foi validado em reuniões semanais com o Grupo de Pesquisa em Computação Aplicada (GPCA). Após isso, deu-se início ao desenvolvimento do sistema que contou com uma camada de apresentação desenvolvida em Javascript, uma interface de programação de aplicativos, do inglês Application Programming Interface (API) desenvolvida em Python, e a integração do Sistema Integrado de Dados Biomédicos (SIDABI), que foi utilizado como banco de dados do sistema. Depois disso, o sistema foi entregue através da computação em nuvem e foi disponibilizado no ambiente web, o módulo desenvolvido contou com 3 telas principais, (I) escolha de perspectiva, UPDRS ou coleta de sensor, (II) lista de pacientes e (III) painel da coleta de sensor. Por fim, o sistema foi submetido a uma sessão de auditoria realizado pela ferramenta Google Lighthouse e também foi apresentado a uma doutoranda em Engenharia Biomédica que trabalha com sensores inerciais aplicados à DP.
Evolution of splicing regulatory networks in Drosophila.
Creators: name: Mcmanus, Charles
name: Coolon, Joseph D.
name: Eipper-Mains, Jodi
name: Wittkopp, Patricia J.
name: Graveley, Brenton R.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The proteome expanding effects of alternative pre-mRNA splicing have had a profound impact on eukaryotic evolution. The events that create this diversity can be placed into four major classes: exon skipping, intron retention, alternative 5' splice sites, and alternative 3' splice sites. Although the regulatory mechanisms and evolutionary pressures among alternative splicing classes clearly differ, how these differences affect the evolution of splicing regulation remains poorly characterized. We used RNA-seq to investigate splicing differences in D. simulans, D. sechellia, and three strains of D. melanogaster. Regulation of exon skipping and tandem alternative 3' splice sites (NAGNAGs) were more divergent than other splicing classes. Splicing regulation was most divergent in frame-preserving events and events in noncoding regions. We further determined the contributions of cis- and trans-acting changes in splicing regulatory networks by comparing allele-specific splicing in F1 interspecific hybrids, because differences in allele-specific splicing reflect changes in cis-regulatory element activity. We find that species-specific differences in intron retention and alternative splice site usage are primarily attributable to changes in cis-regulatory elements (median ∼80% cis), whereas species-specific exon skipping differences are driven by both cis- and trans-regulatory divergence (median ∼50% cis). These results help define the mechanisms and constraints that influence splicing regulatory evolution and show that networks regulating the four major classes of alternative splicing diverge through different genetic mechanisms. We propose a model in which differences in regulatory network architecture among classes of alternative splicing affect the evolution of splicing regulation.
Sur la torsion dans la cohomologie des variétés de Shimura de Kottwitz-Harris-Taylor
Creators: name: Boyer, Pascal
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: When the level at $l$ of a Shimura variety of Kottwitz-Harris-Taylor is not maximal, its cohomology with coefficients in a $\overline{\mathbb Z}_l$-local system isn't in general torsion free. In order to prove torsion freeness results of the cohomology, we localize at a maximal ideal $\mathfrak m$ of the Hecke algebra. We then prove a result of torsion freeness resting either on $\mathfrak m$ itself or on the Galois representation $\overline ρ_{\mathfrak m}$ associated to it. Concerning the torsion, in a rather restricted case than the work of Caraiani-Scholze, we prove that the torsion doesn't give new Satake parameters systems by showing that each torsion cohomology class can be raised in the free part of the cohomology of a Igusa variety.
description: in French
ИМОМ ДОРАҚУТНИЙНИНГ ИЛМИЙ МЕРОCИ
Creators: name: Саидов, Шахбоз
Publisher: name: Zenodo
Year: 2023

description: Имом Дорақутний ўз даврида ҳадис илми борасида уламо ва толиблар кўп мурожаат қиладиган зот бўлганларидек, у кишининг ёзган асарлари ўз даврида ва ундан кейинги даврда ҳам илм аҳли орасида, хусусан муҳаддислар орасида жуда кўп мурожаат қилинадиган асарлар ҳисобланади. У зотдан бизга  қўп ва қимматли китоб ва қўлёзмалар қолган.
Submaximally symmetric c-projective structures
Creators: name: Kruglikov, Boris
name: Matveev, Vladimir
name: The, Dennis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: C-projective structures are analogues of projective structures in the complex setting. The maximal dimension of the Lie algebra of c-projective symmetries of a complex connection on an almost complex manifold of C-dimension $n>1$ is classically known to be $2n^2+4n$. We prove that the submaximal dimension is equal to $2n^2-2n+4+2δ_{3,n}$. If the complex connection is minimal (encoded as a normal parabolic geometry), the harmonic curvature of the c-projective structure has three components and we specify the submaximal symmetry dimensions and the corresponding geometric models for each of these three pure curvature types. If the connection is non-minimal, we introduce a modified normalization condition on the parabolic geometry and use this to resolve the symmetry gap problem. We prove that the submaximal symmetry dimension in the class of Levi-Civita connections for pseudo-Kähler metrics is $2n^2-2n+4$, and specializing to the Kähler case, we obtain $2n^2-2n+3$. This resolves the symmetry gap problem for metrizable c-projective structures.
description: The manuscript was updated and revised. This version corrects some errors in Section 4 that do not influence the main results. The exposition is also slightly polished
Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.
Creators: name: Strachan, Gordon D.
name: Morgan, Kathleen L.
name: Otis, Linda L.
name: Caltagarone, John
name: Aryn Gittis
name: Bowser, Robert
name: Jordan-Sciutto, Kelly L
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The fetal Alz-50 reactive clone 1 (FAC1) protein exhibits altered expression and subcellular localization during neuronal development and neurodegenerative diseases such as Alzheimer's disease. Using the yeast two-hybrid screen, the human orthologue of Keap1 (hKeap1) was identified as a FAC1 interacting protein. Keap1 is an important regulator of the oxidative stress response pathway through its interaction with the Nrf family of transcription factors. An interaction between full-length FAC1 and hKeap1 proteins has been demonstrated, and the FAC1 binding domain of hKeap1 has been identified as the Kelch repeats. In addition, FAC1 colocalizes with endogenous Keap1 within the cytoplasm of PT67 cells. Exogenously introduced eGFP:hKeap1 fusion protein redistributed FAC1 to colocalize with eGFP:hKeap1 in perinuclear, spherical structures. The interaction between FAC1 and hKeap1 is reduced by competition with the Nrf2 protein. However, competition by Nrf2 for hKeap1 is reduced by diethylmaleate (DEM), a known disrupter of the Nrf2:Keap1 interaction. DEM does not affect the ability of FAC1 to bind hKeap1 in our assay. These results suggest that hKeap1 regulates FAC1 in addition to its known role in control of Nrf2. Furthermore, the observed competition between FAC1 and Nrf2 for binding hKeap1 indicates that the interplay between these three proteins has important implications for neuronal response to oxidative stress.
title: Life after residential care : a narrative life-course case study
Creators: name: Keller, Amanda
Publisher: name: Strathprints - University of Strathclyde
Year: 2021

description: This exploratory narrative case study delves into the life trajectories of two English-speaking adults age 50+ who spent over three years in youth protection-based congregate care and aged out of these services in Quebec, Canada. It examines how residential foster care alumni describe their life history and what insights they can provide regarding their transitions to adulthood and parenthood, and their placement experiences. Policy makers, clinicians, and researchers should observe that insights from adults over age 40 are under-examined, and these data point to complex interpersonal difficulties that continue well beyond emerging adulthood. The research indicates intergenerational challenges as an important theme, with both individuals reporting relationship struggles with their families of origin, and healing during their fourth decade of life after crises related to their parental roles. Exploring care leavers' perspectives on healing across their life course may provide invaluable insights about resilience and youth protection practices. These narratives highlight several promising areas of future inquiry that may lead to restitution, healing, and transformative change in child welfare practices.
The Herschel Comprehensive (U)LIRG Emission Survey (HerCULES): CO Ladders, fine structure lines, and neutral gas cooling
Creators: name: Rosenberg, M. J. F.
name: van der Werf, P. P.
name: Aalto, S.
name: Armus, L.
name: Charmandaris, V.
name: Díaz-Santos, T.
name: Evans, A. S.
name: Fischer, J.
name: Gao, Y.
name: González-Alfonso, E.
name: Greve, T. R.
name: Harris, A. I.
name: Henkel, C.
name: Israel, F. P.
name: Isaak, K. G.
name: Kramer, C.
name: Meijerink, R.
name: Naylor, D. A.
name: Sanders, D. B.
name: Smith, H. A.
name: Spaans, M.
name: Spinoglio, L.
name: Stacey, G. J.
name: Veenendaal, I.
name: Veilleux, S.
name: Walter, F.
name: Weiß, A.
name: Wiedner, M. C.
name: van der Wiel, M. H. D.
name: Xilouris, E. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: (Ultra) Luminous Infrared Galaxies ((U)LIRGs) are objects characterized by their extreme infrared (8-1000 $μ$m) luminosities ($L_{LIRG}>10^{11} $L$_\odot$ and $L_{ULIRG}>10^{12}$ L$_\odot$). The Herschel Comprehensive ULIRG Emission Survey (HerCULES; PI van der Werf) presents a representative flux-limited sample of 29 (U)LIRGs that spans the full luminosity range of these objects (10$^{11}\leq L_\odot \geq10^{13}$). With the \emph{Herschel Space Observatory}, we observe [CII] 157 $μ$m, [OI] 63 $μ$m, and [OI] 145 $μ$m line emission with PACS, CO J=4-3 through J=13-12, [CI] 370 $μ$m, and [CI] 609 $μ$m with SPIRE, and low-J CO transitions with ground-based telescopes. The CO ladders of the sample are separated into three classes based on their excitation level. In 13 of the galaxies, the [OI] 63 $μ$m emission line is self absorbed. Comparing the CO excitation to the IRAS 60/100 $μ$m ratio and to far infrared luminosity, we find that the CO excitation is more correlated to the far infrared colors. We present cooling budgets for the galaxies and find fine-structure line flux deficits in the [CII], [SiII], [OI], and [CI] lines in the objects with the highest far IR fluxes, but do not observe this for CO $4\leq J_{upp}\leq13$. In order to study the heating of the molecular gas, we present a combination of three diagnostic quantities to help determine the dominant heating source. Using the CO excitation, the CO J=1-0 linewidth, and the AGN contribution, we conclude that galaxies with large CO linewidths always have high-excitation CO ladders, and often low AGN contributions, suggesting that mechanical heating is important.
The concurrent validity and reliability of virtual reality to measure shoulder flexion and scaption range of motion
Creators: name: Dejaco, Beate
name: D. de Jong, Lex
name: Van Goor, Harry
name: Staal, J. Bart
name: M. Stolwijk, Niki
name: Lewis, Jeremy
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background Shoulder pain commonly has a detrimental impact on patient’s work and social activities. Although pain is the most common reason for seeking care, a reduction in shoulder range of motion (ROM) is another common impairment. ROM assessment is used as an evaluation tool and multiple methods are available to measure shoulder ROM. Virtual reality (VR) has been introduced into shoulder rehabilitation, mostly when exercise and ROM measurement is indicated. This study evaluated the concurrent validity and system reliability of active ROM measurements of VR for people with and without shoulder pain.Methods Forty volunteers participated in this study. Virtual goniometry was used to assess active shoulder ROM. Participants performed flexion and scaption to six predetermined angles. Measurements from the VR goniometer and smartphone inclinometers were recorded simultaneously. To assess reliability, two identical test sequences were performed.Results The concurrent validity ICCs were 0.93 for shoulder flexion and 0.94 for shoulder scaption. The VR goniometer application on average systematically overestimated the ROM compared to the smartphone inclinometer. The mean difference between goniometer values was −11.3 degrees for flexion and −10.9 for scaption. The system reliability was excellent with an overall ICC of 0.99 for the flexion movements and 0.99 for the scaption movements.Conclusion Although the VR system demonstrated excellent reliability, and high ICC’s for concurrent validity, the large range between the lower and upper 95% CI limits suggests it lacks measurement precision. This suggests VR, as used in this study, should not be used interchangeably with other measurement tools.
Bound on Bell Inequalities by Fraction of Determinism and Reverse Triangle Inequality
Creators: name: Joshi, P.
name: Horodecki, K.
name: Horodecki, M.
name: Horodecki, P.
name: Horodecki, R.
name: Li, Ben
name: Szarek, S. J.
name: Szarek, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It is an established fact that entanglement is a resource. Sharing an entangled state leads to non-local correlations and to violations of Bell inequalities. Such non-local correlations illustrate the advantage of quantum resources over classical resources. Here, we study quantitatively Bell inequalities with $2\times n$ inputs. As found in [N. Gisin et al., Int. J. Q. Inf. 5, 525 (2007)] quantum mechanical correlations cannot reach the algebraic bound for such inequalities. In this paper, we uncover the heart of this effect which we call the {\it fraction of determinism}. We show that any quantum statistics with two parties and $2 \times n$ inputs exhibits nonzero fraction of determinism, and we supply a quantitative bound for it. We then apply it to provide an explicit {\it universal upper bound} for Bell inequalities with $2\times n$ inputs. As our main mathematical tool we introduce and prove a {\it reverse triangle inequality}, stating in a quantitative way that if some states are far away from a given state, then their mixture is also. The inequality is crucial in deriving the lower bound for the fraction of determinism, but is also of interest on its own.
description: 11 pages including appendices, 3 figures, Comments welcome
The Effects of Exercise-Induced Ankle Muscle Fatigue on Static Postural Control in Healthy Young Adult Males and Females
Creators: name: Jo, Donguk
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2022
Subjects: Ankle neuromuscular fatigue
Postural control
Sex differences
Rating of perceived exertion (RPE)
Hoffmann's reflex
Spinal propriocetive input at the ankle

description: This thesis describes a series of experiments to investigate sex differences in neuromuscular fatigue mechanisms of the ankle muscles and related postural control changes in healthy young adults. We found that isometric exercise-induced ankle muscle fatigue led not only to significant declines in twitch contractile function and voluntary activation (using twitch interpolation technique, Article 2) but also to significant changes in the center of pressure (COP) sway (backward/right shifts of the COP position and/or increased COP sway velocity) during quiet standing and/or standing forward leaning (FL) task with eyes open and/or eyes closed (Articles 3 and 4). However, we found minor or no significant sex differences in the fatigue mechanisms and fatigue-induced COP sway changes regardless of task difficulty, except for a significant sex X fatigue interaction for COP sway velocity (Article 3). The interaction effect was due to a significant increase in sway velocity in males during the FL task with eyes closed (but not in females), suggesting that males may preferentially rely on ankle control during a relatively challenging task (as compared to females). The general lack of sex differences is not surprising given similar performance and/or perceived fatigability between the sex groups (Articles 2-4), which could be explained by the relatively small differences in contractile function (and/or muscle strength) between males and females for ankle plantar and dorsi flexors compared with other muscle groups. In addition, this thesis involves a scoping review (Article 1), which summarized the broad range of rating of perceived exertion (RPE) values documented in studies observing an effect of muscle fatigue on postural control and suggested the potential effect of various fatigue levels on postural changes. Collectively, these findings advance our understanding of sex-specific fatigue mechanisms and postural control behavior. These findings also indirectly contribute to the understanding of sex differences in injury risks during physically or stability-demanding tasks and sports, as well as to the improvement in the prescription of physical training or rehabilitation exercise.
Firing properties of GABAergic versus non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents.
Creators: name: Aryn Gittis
name: Lac, Sascha Du
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Neural circuits are composed of diverse cell types, the firing properties of which reflect their intrinsic ionic currents. GABAergic and non-GABAergic neurons in the medial vestibular nuclei, identified in GIN and YFP-16 lines of transgenic mice, respectively, exhibit different firing properties in brain slices. The intrinsic ionic currents of these cell types were investigated in acutely dissociated neurons from 3- to 4-wk-old mice, where differences in spontaneous firing and action potential parameters observed in slice preparations are preserved. Both GIN and YFP-16 neurons express a combination of four major outward currents: Ca(2+)-dependent K(+) currents (I(KCa)), 1 mM TEA-sensitive delayed rectifier K(+) currents (I(1TEA)), 10 mM TEA-sensitive delayed rectifier K(+) currents (I(10TEA)), and A-type K(+) currents (I(A)). The balance of these currents varied across cells, with GIN neurons tending to express proportionately more I(KCa) and I(A), and YFP-16 neurons tending to express proportionately more I(1TEA) and I(10TEA). Correlations in charge densities suggested that several currents were coregulated. Variations in the kinetics and density of I(1TEA) could account for differences in repolarization rates observed both within and between cell types. These data indicate that diversity in the firing properties of GABAergic and non-GABAergic vestibular nucleus neurons arises from graded differences in the balance and kinetics of ionic currents.
Fluorescent DNA nanotags: supramolecular fluorescent labels based on intercalating dye arrays assembled on nanostructured DNA templates.
Creators: name: Benvin, Andrea L.
name: Creeger, Yehuda
name: Fisher, Gregory
name: Ballou, Byron
name: Waggoner, Alan
name: Armitage, Bruce
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Fluorescence detection and imaging are vital technologies in the life sciences and clinical diagnostics. The key to obtaining high-resolution images and sensitive detection is to use fluorescent molecules or particles that absorb and emit visible light with high efficiency. We have synthesized supramolecular complexes consisting of a branched DNA template and fluorogenic intercalating dyes. Because dyes can intercalate up to every other base pair, high densities of fluorophores are assembled yet the DNA template keeps them far enough away from each other to prevent self-quenching. The efficiency with which these noncovalent assemblies absorb light is more than 10-fold greater than that of the individual dye molecules. Förster resonance energy transfer from the intercalated dyes to covalently attached acceptor dyes is very efficient, allowing for wavelength shifting of the emission spectrum. Simple biotinylation of the DNA template allows for labeling of streptavidin-coated synthetic microspheres and mouse T-cells.
title: An exploration of distance and home when looked after : views of young people
Creators: name: Mclaughlan, Carrie F
Publisher: name: Strathprints - University of Strathclyde
Year: 2021

description: This qualitative research explored how distance relates to young people's experiences of being looked after away from home. It sought views of young people living in residential care in Scotland using semi-structured interviews. Thematic Analysis was used to elicit key themes. A global theme of 'Connections' was identified. Feelings of distance were related to how connected or disconnected young people felt towards relationships and places. These 'Connections' were supported through Contact and Familiarity. Themes of feeling disconnected from home, and subsequently feeling further away from home related to a perceived sense of control and constraint from being in care. Shame, guilt and anxiety contributed to feeling disconnected. Feelings of connectedness and/or disconnectedness to home influenced young people’s views of their own risk-taking behaviour. This research highlights the relevance of other factors, not just proximity when considering placing young people in care away from home.
THE IMPACT OF FOREIGN PROPERTY ON THE PERFORMANCE OF MOROCCAN COMPANIES DURING COVID19 CRISIS: THE CASE OF COMPANIES LISTED ON THE CASABLANCA STOCK EXCHANGE
Creators: name: AIT HBIBI AMINA, (PhD)
name: GHARRAFI MEHDI, (PhD)
Publisher: name: Zenodo
Year: 2023
Subjects: Performance-Casablanca Stock Exchange-Foreign Participation-Covid19

description: Abstract
In this study, we analyzed the impact of foreign ownership on the performance of Moroccan companies during the COVID19 crisis. The analysis was based on the study of the performance of companies listed on the Casablanca Stock Exchange on the basis of the criterion of foreign participation. The methodology deployed made it possible to compare local companies with foreign companies during the period from 19-11 to 19/06, we found a comparability of performance between the two groups of companies.
High redshift AGNs and HI reionisation: limits from the unresolved X-ray background
Creators: name: Haardt, Francesco
name: Salvaterra, Ruben
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The rapidly declining population of bright quasars at z~3 appears to make an increasingly small contribution to the ionising background at the HI Lyman limit. It is then generally though that massive stars in (pre-)galactic systems may provide the additional ionising flux needed to complete HI reionisation by z>6. A galaxy dominated background, however, may require that the escape fraction of Lyman continuum radiation from high redshift galaxies is as high as 10%, a value somewhat at odds with (admittedly scarce) observational constraints. High escape fractions from dwarf galaxies have been advocated, or, alternatively, a so-far undetected (or barely detected) population of unobscured, high-redshift faint AGNs. Here we question the latter hypothesis, and show that such sources, to be consistent with the measured level of the unresolved X-ray background at z=0, can provide a fraction of the HII filling factor not larger than 13% by z=6. The fraction rises to <27% in the somewhat extreme case of a constant comoving redshift evolution of the AGN emissivity. This still calls for a mean escape fraction of ionising photons from high-z galaxies >10%.
description: A&A Letter, accepted (4 pages, 2 figures)
Fungal morphogenesis: in hot pursuit.
Creators: name: Wenjie  Xu
name: Mitchell, Aaron
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Temperature affects diverse biological processes. In fungi such as the pathogen Candida albicans, temperature governs a morphogenetic switch between yeast and hyphal growth. A new report connects the thermosensor Hsp90 to a CDK-cyclin-transcription factor module that controls morphogenesis.
Approximate message-passing decoder and capacity-achieving sparse superposition codes
Creators: name: Barbier, Jean
name: Krzakala, Florent
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We study the approximate message-passing decoder for sparse superposition coding on the additive white Gaussian noise channel and extend our preliminary work [1]. We use heuristic statistical-physics-based tools such as the cavity and the replica methods for the statistical analysis of the scheme. While superposition codes asymptotically reach the Shannon capacity, we show that our iterative decoder is limited by a phase transition similar to the one that happens in Low Density Parity check codes. We consider two solutions to this problem, that both allow to reach the Shannon capacity: i) a power allocation strategy and ii) the use of spatial coupling, a novelty for these codes that appears to be promising. We present in particular simulations suggesting that spatial coupling is more robust and allows for better reconstruction at finite code lengths. Finally, we show empirically that the use of a fast Hadamard-based operator allows for an efficient reconstruction, both in terms of computational time and memory, and the ability to deal with very large messages.
description: 40 pages, 18 figures
Does Attractiveness Benefit Black People More Than White People?
Creators: name: Baraah
name: Bar-Anan, Yoav
name: Navon, Mayan
name: Grynhaus, Mae
name: tubis, shalev
name: mizrahi, michal
name: kipper, noa
name: Heresco, Yuval
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: This is our research plan for the research that we conducted in the Automatic Social Judgment seminar, in Tel Aviv University, Israel.
Brain Tumor Detection Based on Bilateral Symmetry Information
Creators: name: Sachin, Narkhede
name: Shah, Deven
name: Khairnar, Vaishali
name: Kadu, Sujata
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Advances in computing technology have allowed researchers across many fields of endeavor to collect and maintain vast amounts of observational statistical data such as clinical data,biological patient data,data regarding access of web sites,financial data,and the like.Brain Magnetic Resonance Imaging(MRI)segmentation is a complex problem in the field of medical imaging despite various presented methods.MR image of human brain can be divided into several sub regions especially soft tissues such as gray matter,white matter and cerebrospinal fluid.Although edge information is the main clue in image segmentation,it can not get a better result in analysis the content of images without combining other information.The segmentation of brain tissue in the magnetic resonance imaging(MRI)is very important for detecting the existence and outlines of tumors.In this paper,an algorithm about segmentation based on the symmetry character of brain MRI image is presented.Our goal is to detect the position and boundary of tumors automatically.Experiments were conducted on real pictures,and the results show that the algorithm is flexible and convenient.
description: 06 pages,02 figures,06 graphs. arXiv admin note: text overlap with arXiv:1403.6002
title: The story of the first-ever care experienced history month
Creators: name: Armitage, Charlotte
Publisher: name: Strathprints - University of Strathclyde
Year: 2021

description: The first-ever Care Experienced History Month took place in April 2021. Announced in Scotland in September 2020, Care Experienced History Month was celebrated across the world by Care Experienced people and their allies. The month aimed to draw attention to the rich and far-reaching history of Care Experienced people by connecting the past with the present and sharing the legacies of Care Experienced people who lived before us. This article explores the process that led to the creation of Care Experienced History Month, worldwide collaborations involved in the delivery of the month, the overall aims of the month, and an overview of the content created and shared throughout April 2021.
Getting the message out.
Creators: name: Mcmanus, Charles
name: Graveley, Brenton R.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In a recent issue of Molecular Cell, Schwer (2008) demonstrates that, during the latest stage of the splicing reaction, the RNA-dependent helicase Prp22 is deposited upon the downstream exon, where it subsequently strips the spliced messenger RNA from the spliceosome.
GRASP65 controls the cis Golgi integrity in vivo.
Creators: name: Veenendaal, Tineke
name: Jarvela, Timothy S.
name: Grieve, Adam G.
name: Es, Johan H. Van
name: Linstedt, Adam
name: Rabouille, Catherine
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: GRASP65 and GRASP55 are peripheral Golgi proteins localized to cis and medial/trans cisternae, respectively. They are implicated in diverse aspects of protein transport and structure related to the Golgi complex, including the stacking of the Golgi stack and/or the linking of mammalian Golgi stacks into the Golgi ribbon. Using a mouse model, we interfered with GRASP65 by homologous recombination and confirmed its absence of expression. Surprisingly, the mice were healthy and fertile with no apparent defects in tissue, cellular or subcellular organization. Immortalized MEFs derived from the mice did not show any growth or morphological defects. However, despite the normal appearance of the Golgi ribbon, a fluorescence recovery after photobleaching assay revealed functional discontinuities specific to the cis cisternal membrane network. This leads to a strong change in the plasma membrane GSII lectin staining that was also observed in certain mutant tissues. These findings substantiate the role of GRASP65 in continuity of the cis Golgi network required for proper glycosylation, while showing that neither this continuity nor GRASP65 itself are essential for the viability of a complex organism.
Broadband distortion modeling in Lyman-$α$ forest BAO fitting
Creators: name: Blomqvist, Michael
name: Kirkby, David
name: Bautista, Julian E.
name: Arinyo-i-Prats, Andreu
name: Busca, Nicolás G.
name: Miralda-Escudé, Jordi
name: Slosar, Anže
name: Font-Ribera, Andreu
name: Margala, Daniel
name: Schneider, Donald P.
name: Vazquez, Jose A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In recent years, the Lyman-$α$ absorption observed in the spectra of high-redshift quasars has been used as a tracer of large-scale structure by means of the three-dimensional Lyman-$α$ forest auto-correlation function at redshift $z\simeq 2.3$, but the need to fit the quasar continuum in every absorption spectrum introduces a broadband distortion that is difficult to correct and causes a systematic error for measuring any broadband properties. We describe a $k$-space model for this broadband distortion based on a multiplicative correction to the power spectrum of the transmitted flux fraction that suppresses power on scales corresponding to the typical length of a Lyman-$α$ forest spectrum. Implementing the distortion model in fits for the baryon acoustic oscillation (BAO) peak position in the Lyman-$α$ forest auto-correlation, we find that the fitting method recovers the input values of the linear bias parameter $b_{F}$ and the redshift-space distortion parameter $β_{F}$ for mock data sets with a systematic error of less than 0.5\%. Applied to the auto-correlation measured for BOSS Data Release 11, our method improves on the previous treatment of broadband distortions in BAO fitting by providing a better fit to the data using fewer parameters and reducing the statistical errors on $β_{F}$ and the combination $b_{F}(1+β_{F})$ by more than a factor of seven. The measured values at redshift $z=2.3$ are $β_{F}=1.39^{+0.11\ +0.24\ +0.38}_{-0.10\ -0.19\ -0.28}$ and $b_{F}(1+β_{F})=-0.374^{+0.007\ +0.013\ +0.020}_{-0.007\ -0.014\ -0.022}$ (1$σ$, 2$σ$ and 3$σ$ statistical errors). Our fitting software and the input files needed to reproduce our main results are publicly available.
description: 28 pages, 15 figures, matches the published version
Implementation of the Shared Governance of the Human Capital of the Nursing: An integrative review.
Creators: name: De Matos Rodrigues, Luciana Galdina
name: Nassar, Pedro Ruiz Barbosa
name: Maithê De Carvalho E Lemos Goulart
Publisher: name: Open Science Framework
Year: 2023

description: This is an integrative review protocol on the implementation of shared governance of nursing human capital. It aims to formalize the primary study. The protocol defines the paths that will be adopted in the secondary study of Integrative Review, and was prepared based on The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. (1) The review is expected to map the best evidence available in the literature related to the implementation of shared governance of nursing human capital.
Historicizing Power and Legitimacy After the Social Justice Turn: Resisting Narcissistic Tendencies
Creators: name: Shelton, Cecilia D.
name: Warren-Riley, Sarah
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: As a field committed to solving problems, technical and professional communication (TPC) seems well positioned to engage the challenges that come with social justice work intellectually and respond with practical solutions. In this article, the authors argue that power and legitimacy are critical terms that can propel our social justice work, if we can recast them in our disciplinary history and ultimately renegotiate them in the trajectories of our disciplinary futures.
The formation of trapped surfaces in spherically-symmetric Einstein-Euler spacetimes with bounded variation
Creators: name: Burtscher, Annegret Y.
name: LeFloch, Philippe G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 83C05, 35L60, 76N10

description: We study the evolution of a self-gravitating compressible fluid in spherical symmetry and we prove the existence of weak solutions with bounded variation for the Einstein-Euler equations of general relativity. We formulate the initial value problem in Eddington-Finkelstein coordinates and prescribe spherically symmetric data on a characteristic initial hypersurface. We introduce here a broad class of initial data which contain no trapped surfaces, and we then prove that their Cauchy development contains trapped surfaces. We therefore establish the formation of trapped surfaces in weak solutions to the Einstein equations. This result generalizes a theorem by Christodoulou for regular vacuum spacetimes (but without symmetry restriction). Our method of proof relies on a generalization of the "random choice" method for nonlinear hyperbolic systems and on a detailed analysis of the nonlinear coupling between the Einstein equations and the relativistic Euler equations in spherical symmetry.
description: 46 pages
Infinite loop spaces and nilpotent K-theory
Creators: name: Adem, Alejandro
name: Gómez, José Manuel
name: Lind, John A.
name: Tillmann, Ulrike
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: Using a construction derived from the descending central series of the free groups, we produce filtrations by infinite loop spaces of the classical infinite loop spaces $BSU$, $BU$, $BSO$, $BO$, $BSp$, $BGL_{\infty}(R)^{+}$ and $Q_0(\mathbb{S}^{0})$. We show that these infinite loop spaces are the zero spaces of non-unital $E_\infty$-ring spectra. We introduce the notion of $q$-nilpotent K-theory of a CW-complex $X$ for any $q\ge 2$, which extends the notion of commutative K-theory defined by Adem-Gómez, and show that it is represented by $\mathbb Z\times B(q,U)$, were $B(q,U)$ is the $q$-th term of the aforementioned filtration of $BU$. For the proof we introduce an alternative way of associating an infinite loop space to a commutative $\mathbb{I}$-monoid and give criteria when it can be identified with the plus construction on the associated limit space. Furthermore, we introduce the notion of a commutative $\mathbb{I}$-rig and show that they give rise to non-unital $E_\infty$-ring spectra.
description: To appear in Algebraic and geometric topology
Supplementary document for Surface plasmon resonance sensor using polarization-maintaining fiber on hetero-core optical fiber structure with gold thin film - 6000861.pdf
Creators: name: Hosoki, Ai
name: Nishiyama, Michiko
name: Watanabe, Kazuhiro
name: Sakurai, Nozomu
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplementary figures
Infinite matrix product states, boundary conformal field theory, and the open Haldane-Shastry model
Creators: name: Tu, Hong-Hao
name: Sierra, Germán
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show that infinite Matrix Product States (MPS) constructed from conformal field theories can describe ground states of one-dimensional critical systems with open boundary conditions. To illustrate this, we consider a simple infinite MPS for a spin-1/2 chain and derive an inhomogeneous open Haldane-Shastry model. For the spin-1/2 open Haldane-Shastry model, we derive an exact expression for the two-point spin correlation function. We also provide an SU($n$) generalization of the open Haldane-Shastry model and determine its twisted Yangian generators responsible for the highly degenerate multiplets in the energy spectrum.
description: 5+7 pages, 4 figures, published version, a typo in the twisted Yangian generators corrected (thanks to the authors of arXiv:1511.08613 for pointing out this typo)
Fine-mapping reveals novel alternative splicing of the dopamine transporter.
Creators: name: Talkowski, Michael E.
name: McCann, Kathleen L.
name: Chen, Michael
name: McClain, Lora
name: Mikhil  Bamne
name: Wood, Joel
name: Kodavali V. Chowdari
name: Watson, Annie
name: Konasale M. Prasad
name: Kirov, George
name: Lyudmilla  Georgieva
name: Toncheva, Draga
name: Hader  Mansour
name: Lewis, David A.
name: Owen, Michael
name: O'Donovan, Michael
name: Papasaikas, Panagiotis
name: Sullivan, Patrick
name: Ruderfer, Douglas
name: Yao, Jeffrey K.
name: Leonard, Sherry
name: Thomas, Pramod
name: Miyajima, Fabio
name: Quinn, John
name: Antonio-Javier Lopez
name: Vishwajit L. Nimgaonkar
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The dopamine transporter gene (SLC6A3, DAT) has been implicated in the pathogenesis of numerous psychiatric and neurodevelopmental disorders, including schizophrenia (SZ). We previously detected association between SZ and intronic SLC6A3 variants that replicated in two independent Caucasian samples, but had no obvious function. In follow-up analyses, we sequenced the coding and intronic regions of SLC6A3 to identify complete linkage disequilibrium patterns of common variations. We genotyped 78 polymorphisms, narrowing the potentially causal region to two correlated clusters of associated SNPs localized predominantly to introns 3 and 4. Our computational analysis of these intronic regions predicted a novel cassette exon within intron 3, designated E3b, which is conserved among primates. We confirmed alternative splicing of E3b in post-mortem human substantia nigra (SN). As E3b introduces multiple in-frame stop codons, the SLC6A3 open reading frame is truncated and the spliced product may undergo nonsense mediated decay. Thus, factors that increase E3b splicing could reduce the amount of unspliced product available for translation. Observations consistent with this prediction were made using cellular assays and in post-mortem human SN. In mini-gene constructs, the extent of splicing is also influenced by at least two common haplotypes, so the alternative splicing was evaluated in relation to SZ risk. Meta-analyses across genome-wide association studies did not support the initial associations and further post-mortem studies did not suggest case-control differences in splicing. These studies do not provide a compelling link to schizophrenia. However, the impact of the alternative splicing on other neuropsychiatric disorders should be investigated. © 2010 Wiley-Liss, Inc.
Half-site inhibition of dimeric kinesin head domains by monomeric tail domains.
Creators: name: Hackney, David
name: Nahyeon  Baek
name: Avin C. Snyder
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The two heavy chains of kinesin-1 are dimerized through extensive coiled coil regions and fold into an inactive conformation through interaction of the C-terminal tail domains with the N-terminal motor (head) domains. Although this potentially allows a dimer of tail domains to interact symmetrically with a dimer of head domains, we report here that only one of the two available monomeric tail peptides is sufficient for tight binding and inhibition of a dimer of head domains. With a dimeric tail construct, the other tail peptide does not make tight contact with the head dimer and can bind a second head dimer to form a complex containing one tail dimer and two head dimers. The IAK domain and neighboring positively charged region of the tail is sufficient for tight half-site interaction with a dimer of heads. The interaction of tails with monomeric heads is weak, but a head dimer produced by the dimerization of the neck coil is not required because an artificial dimer of head domains also binds monomeric tail peptides with half-site stoichiometry in the complete absence of the native neck coil. The binding of tail peptides to head dimers is fast and readily reversible as determined by FRET between mant-ADP bound to the head dimer and a tail labeled with GFP. The association and dissociation rates are 81 microM(-1) s(-1) and 32 s(-1), respectively. This half-site interaction suggests that the second tail peptide in a folded kinesin-1 might be available to bind other molecules while kinesin-1 remained folded.
МОВАРОУННАҲРДА ҲАДИС ИЛМИ РИВОЖИ
Creators: name: Якубов, Азимжон
Publisher: name: Zenodo
Year: 2023

description: Аллоҳ таоло юртимизни Ислом нури билан мунаввар қилганда, баъзи саҳобаи киромларга Нисо ва Марв каби шаҳарларда истиқомат қилишларини насиб этди. Албатта, саҳоба розияллоҳу анҳумлар бор жойда ҳадис дарслари уюштирилади. Одамлар теварак атрофдан улар бор жойга кела бошладилар.