cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Beyond PRONADE: NGOs and the Formal Education Sector in Guatemala
Creators: name: Carter, Jacob A.
Publisher: name: University of Massachusetts Amherst
Year: 2012
Subjects: subject: Guatemala
subject: NGO
subject: PRONADE
subject: National Program for Self-Managed Schools for Educational Development
subject: Interviews
subject: Policymakers
subject: Education
subject: Ministry of Education
subject: Bilingual, Multilingual, and Multicultural Education
subject: Educational Assessment, Evaluation, and Research
subject: Education Economics

description: In Guatemala, the Ministry of Education (MoE) is overburdened with challenges;these include the most basic provision of services and support for public schools across the country. In the absence of a capable state presence, countless nongovernmental organizations (NGO) have sprung up to provide, sustain and/or take over basic education services. These NGOs come in all shapes and sizes, with different motivations, from different countries and receiving funding from a variety of national and international sources. The combination of rapidly increasing numbers of NGOs along with minimal state coordination means that the Ministry is unaware of the number of NGOs operating in the education sector, much less what they are doing, where they are and the capabilities that they bring to the sector. Recent estimates place the number of NGOs in Guatemala upwards of 10,000 with no definitive number to be determined in the near future. The National Program for Self-Managed Schools for Educational Development (PRONADE) from 1994 – 2007 was the first large-scale initiative to include NGOs in the provision of public education. The participating NGOs delivered technical services such as pedagogical training and financial reporting. However, more recently, there have been an increase in smaller foreign and national NGOs that are interacting with the education sector in new ways. This study interviews six of these smaller NGOs along with four different policymakers working at the national level to inquire about their views on NGOs working in the education sector. This study finds that the participant NGOs are involved in a complex set of interactions with the formal education sector primarily at the local level. This includes active and dependent partnerships at the local and ministerial levels and the supplementation and replacement of public services. Despite all of this NGO activity,there is a dearth of information on NGOs working in the formal education sector in Guatemala. And finally, both policymakers and NGOs expressed their interest in future NGO-MoE partnerships although each envisions such partnerships differently.
Il silbo, la lingua degli uccelli e le tradizioni iniziatiche / Silbo, la birdolingvo kaj la inicaj tradicioj
Creators: name: Gualandri, Francesca
Publisher: name: Università degli Studi di Milano
Year: 2011

description: Abstract Le lingue fischiate, come il silbo, vengono studiate solitamente   da punti di vista strettamente linguistici. In questo contributo si  intende presentare un'analisi del silbo da un punto di vista  diverso, legato all'antropologia comparata e  all'etnomusicologia. Vengono messe in luce le probabili funzioni del  Silbo nei  rituali religiosi dell'antico popolo dei Guanches attraverso un  excursus transculturale della simbologia della lingua degli uccelli.Resumo La fajflingvoj kiel ekzemple Silbo, estas kutime studataj strikte vidpunkte   de lingvistiko. En ĉi tiu kontribuo oni intencas prezenti  analizon de Silbo el diversa vidpunkto, nome kompara antropologio   kaj etnomuzikologio. Oni klarigas la eblajn funkciojn de Silbo en   la religiaj ritoj de la antikva popolo de Guanĉoj per   transkultura trairo pri la simbologio de la birdolingvo.
description: InKoj. Interlingvistikaj Kajeroj, Vol 2, No 1 (2011): Chronicles of a Pivot Language / Kronikoj de Pontolingvo
The power of silence: The question of reserve in four Victorian novels.
Creators: name: Timonin, Ann Veronica.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Literature, English.

description: Victorian women's silence has been the subject of investigation by many feminist critics, and most have understood it as a function of repression. More recently, however, feminists have begun to recognise more productive levels of silence. This thesis examines four Victorian novels that show that silence is not a stable social sign with a clear meaning but an aspect of the Victorian convention of femininity that can mean different things and be used in different ways. Chapter One looks at silence and choice in Elizabeth Gaskell's North and South, tracing the implications of choosing reserve. Chapter Two turns to a consideration of self-silencing and sanity in Charlotte Bronte's Villette, while Chapter Three looks at secrecy and survival in Anne Bronte's The Tenant of Wildfell Hall. The thesis concludes with a reading of George Eliot's The Mill on the Floss in Chapter Four that concentrates on the risks of using silence as retreat into a fantasy space.
The changing nature of the relationship between First Nations and museums.
Creators: name: Robertson, Céline.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Education, Administration.

description: This research paper is elaborated around the hypothesis that there is a subtle resistance by non-aboriginal museum professionals, primarily within the disciplines of anthropology, in accepting First Nations taking complete control of their identities and cultures. This new changing situation minimizes the museum professionals' power as interpreters of First Nations' cultures and no longer corresponds to the mission and purpose of the disciplines of anthropology. The author develops the argument by examining Eilean Hooper-Greenill's study of Michel Foucault's three epistemes on how museums influenced the shaping of knowledge in the transition from one epistemic period to the next. Hooper-Greenhill's analysis is further used to illustrate the impact the present social changes are having on museums and First Nations. The Canadian Museum of Civilization is used as an example and is analyzed in part using Patricia Pitcher's study of leaders in organizations and the author's own personal observations.
Alcoholism treatment digest (Release No. 81, October 14, 1966)
Creators: name: Keller, Mark
Publisher: name: No Publisher Supplied
Year: 1966

description: The Alcoholism Treatment Digest was a subscription-based publication prepared for special clients by the editorial department of the Quarterly Journal of Studies on Alcohol / Journal of Studies on Alcohol from 1950 to 1973 with Mark Keller as editor. It was published in February, April, June, October, and December, summarizing scholarly content on four topics, available to republish with attribution. Some of the reviews were simultaneously published in the "Connecticut Review on Alcoholism" under the identical subtitle "Alcoholism Treatment Digest" every other month. The authors of the reviews were first noted in 1964, in the June issue.Contents, Release No. 811.Group Principles In Earl lest Phases of Treatment of Alcoholism2.Hypnotic Aversion to Alcohol: A Case History3.Evaluating Treatment of Alcoholism with NAO4.Another Anti-alcohol Drug5.Treatment of the Alcoholic in the State Mental Hospital
Uncontrolled Outdoor Access for Cats: An Assessment of Risks and Benefits
Creators: name: Tan, Sarah M.L.
name: Stellato, Anastasia C.
name: Niel, Lee
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Uncontrolled outdoor access is associated with a number of welfare concerns for companion cats, including increased risks of disease and parasites, injury or death due to traffic, predation or ingestion of toxic substances, and getting permanently separated from their owner. In addition, cats pose a threat to local wildlife due to predatory behaviors, and can sometimes be a nuisance to human neighbors. Despite these concerns, recent estimates suggest that many owners are still providing their cats with uncontrolled outdoor access, likely because it also offers welfare benefits by allowing cats to perform natural behaviors, such as hunting, exploring, and climbing. While some have suggested that outdoor access is necessary to meet cats’ behavioral needs and to prevent related behavioral problems, others have recommended various environmental enrichment strategies that can be developed to meet these needs within an indoor environment or through supervised and controlled outdoor access. This review examines the welfare issues and benefits associated with outdoor access for cats, as well as what is currently known about peoples’ practices, knowledge, and attitudes about the provision of outdoor access for cats.
Computational Methods for Inferring Transcription Factor Binding Sites
Creators: name: Morozov, Vyacheslav
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: machine learning
transcriptional regulatory sites
transcription factor
protein binding
PWM
PSSM
DNA sequence
optimization
statistics
binding site
prediction
computational methods
Matthews correlation
Drosophila melanogaster
binding motif
weight matrix
DNA sequence analysis

description: Position weight matrices (PWMs) have become a tool of choice for the identification of transcription factor binding sites in DNA sequences. PWMs are compiled from experimentally verified and aligned binding sequences. PWMs are then used to computationally discover novel putative binding sites for a given protein. DNA-binding proteins often show degeneracy in their binding requirement, the overall binding specificity of many proteins is unknown and remains an active area of research. Although PWMs are more reliable predictors than consensus string matching, they generally result in a high number of false positive hits. A previous study introduced a novel method to PWM training based on the known motifs to sample additional putative binding sites from a proximal promoter area. The core idea was further developed, implemented and tested in this thesis with a large scale application. Improved mono- and dinucleotide PWMs were computed for Drosophila melanogaster. The Matthews correlation coefficient was used as an optimization criterion in the PWM refinement algorithm. New PWMs keep an account of non-uniform background nucleotide distributions on the promoters and consider a larger number of new binding sites during the refinement steps. The optimization included the PWM motif length, the position on the promoter, the threshold value and the binding site location. The obtained predictions were compared for mono- and dinucleotide PWM versions with initial matrices and with conventional tools. The optimized PWMs predicted new binding sites with better accuracy than conventional PWMs.
title: Bioassays to assess unpredictable substances from drinking water contact materials
title: Bioassays to assess unpredictable substances from drinking water contact materials
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2018
Subjects: subject: Trinkwasser
subject: Bioassay
subject: drinking water
subject: Water

description: Within the project "bioassay-based test strategy to determine risk potentials of migration waters" the German Environment Agency (UBA ) and the Association for Pipe Systems Inside Buildings (VRH) had the common aim to develop a test strategy based on established bioassays. This in vitro test strategy detects cytotoxicity, genotoxicity and estrogenic like activity of migration waters. Quelle: https://www.umweltbundesamt.de
description: Within the project „bioassay-based test strategy to determine risk potentials of migration waters“ the German Environment Agency (⁠UBA⁠) and the Association for Pipe Systems Inside Buildings (VRH) had the common aim to develop a test strategy based on established bioassays. This in vitro test strategy detects cytotoxicity, genotoxicity and estrogenic like activity of migration waters.
Supplementary document for Optically controlled ultrafast terahertz switching in wafer scale PtSe2 thin films - 5220518.pdf
Creators: name: Fu, Jibo
name: Jiang, Meng
name: Suo, Peng
name: Zhang, Wenjie
name: Lin, Xian
name: Yan, Xiaona
name: Zhang, Saifeng
name: Ma, Guo-Hong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Nonlinear Optics and Spectroscopy

description: supplementary information
Design curriculum challenges for today's university
Creators: name: Friedman, Ken
Publisher: name: Swinburne
Year: 2024

description: Curriculum development is a large systemic enterprise. Curriculum involves course planning, course content, pedagogical delivery, and learning objectives for the individual teacher. For the student, it involves learning styles, personal development, mastery of content, and mastery of skills. At the program level, it requires coordination among teachers and across courses. At the school and university level, it involves other issues still. In design, curriculum development involves eight kinds of education. In university, these include undergraduate education, professional education, and research training. Many schools also offer lifelong learning, continuing education, and executive education. Some schools offer vocational training and special courses. Design is both a field of professional practice and a research discipline. The plural dimensions of research and practice both affect curriculum needs.
North Rupununi Wildlife Clubs: Makushi Amerindians’ Perceptions of Environmental Education and Positive Youth Development in Guyana
Creators: name: Comber, Julie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Amerindian
Elders
Clubs
Environmental Education
Guyana
Indigenous
Makushi
Positive Youth Development
Youth

description: This doctoral research studied the North Rupununi Wildlife Clubs (NRWC), an Environmental Education (EE) Program for Makushi Amerindian youth in Guyana. The Club format for EE has become popular, and previous research on EE Club programs provide modest support for the hypothesis that EE Club membership increases pro-environmental attitudes and behaviour in children and youth. There is also increasing interest in the role EE Clubs can play in nurturing Positive Youth Development (PYD). This multi-site case study describes EE Clubs in three villages in the North Rupununi of Guyana. Data was collected from semi-structured interviews and focus groups with stakeholders (such as former Club members, volunteers with the Clubs, Elders, and village leaders). The researcher also kept a reflective journal. Findings suggest community members valued the positive impact they perceived participation in NRWC to have on youth and upon their community. Participants offered recommendations on how to improve the program. One of the original findings is that the Clubs may be a way to help reconnect indigenous youth with their elders and restore the transmission of Indigenous Knowledge. These findings contribute to our understanding of EE Clubs and their impact on pro-environmental behaviour, PYD, and communities. This may be relevant to other indigenous communities in isolated rural areas with EE Clubs, and to the field of EE in general.
Performance of Steel Fibre Reinforced Concrete Columns under Shock Tube Induced Shock Wave Loading
Creators: name: Burrell, Russell P.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Blast
Concrete
Column
Steel Fibres
Seismic Detailing
Steel Fibre Reinforced Concrete
Self Consolidating Concrete
Ultra High Performance Concrete
Structural Blast Resistance
Fibre Reinforced Concrete

description: It is important to ensure that vulnerable structures (federal and provincial offices, military structures, embassies, etc) are blast resistant to safeguard life and critical infrastructure. In the wake of recent malicious attacks and accidental explosions, it is becoming increasingly important to ensure that columns in structures are properly detailed to provide the ductility and continuity necessary to prevent progressive collapse. Research has shown that steel fibre reinforced concrete (SFRC) can enhance many of the properties of concrete, including improved post-cracking tensile capacity, enhanced shear resistance, and increased ductility. The enhanced properties of SFRC make it an ideal candidate for use in the blast resistant design of structures. There is limited research on the behaviour of SFRC under high strain rates, including impact and blast loading, and some of this data is conflicting, with some researchers showing that the additional ductility normally evident in SFRC is absent or reduced at high strain loading. On the other hand, other data indicates that SFRC can improve toughness and energy-absorption capacity under extreme loading conditions. This thesis presents the results of experimental research involving tests of scaled reinforced concrete columns exposed to shock wave induced impulsive loads using the University of Ottawa Shock Tube. A total of 13 half-scale steel fibre reinforced concrete columns, 8 with normal strength steel fibre reinforced concrete (SFRC) and 5 with an ultra high performance fibre reinforced concrete (UHPFRC), were constructed and tested under simulated blast pressures. The columns were designed according to CSA A23.3 standards for both seismic and non-seismic regions, using various fibre amounts and types. Each column was exposed to similar shock wave loads in order to provide direct comparisons between seismic and non-seismically detailed columns, amount of steel fibres, type of steel fibres, and type of concrete. The dynamic response of the columns tested in the experimental program is predicted by generating dynamic load-deformation resistance functions for SFRC and UHPFRC columns and using single degree of freedom dynamic analysis software, RCBlast. The analytical results are compared to experimental data, and shown to accurately predict the maximum mid-span displacements of the fibre reinforced concrete columns under shock wave loading.
Decision-making about antidepressant medication use in pregnancy: a comparison between women making the decision in the preconception period versus in pregnancy
Creators: name: Barker, Lucy C.
name: Dennis, Cindy-Lee
name: Hussain-Shamsy, Neesha
name: Stewart, Donna E.
name: Grigoriadis, Sophie
name: Metcalfe, Kelly
name: Oberlander, Tim F.
name: Schram, Carrie
name: Taylor, Valerie H.
name: Vigod, Simone N.
Publisher: name: BioMed Central
Year: 2020

description: Background: Decisions about antidepressant use in pregnancy are complex. Little is known about how pregnancy-planning and already pregnant women making these decisions differ. Methods: In 95 Canadian women having difficulty deciding whether to take antidepressants in pregnancy, we compared sociodemographic factors, clinical characteristics, and treatment intent between women planning pregnancy (preconception women) and currently-pregnant women. Results: About 90% of preconception women (n = 55) were married or cohabitating and university-educated, and over 60% had an annual income of > 80,000 CAD/year; this was not different from currently-pregnant women (n = 40). Almost all women had previously used antidepressants, but preconception women were more likely to report current use (85.5% vs. 45.0%). They were more likely to have high decisional conflict (83.6% vs. 60.0%) and less likely to be under the care of a psychiatrist (29.1% vs. 52.5%). Preconception women were more likely than pregnant women to report the intent to use antidepressants (60% vs. 32.5%, odds ratio 3.11, 95% confidence interval 1.33–7.32); this was partially explained by between-group differences in current antidepressant use. Conclusions: Preconception women were more likely than pregnant women to intend to use antidepressants in pregnancy, in part because more of them were already using this treatment. Strategies to enhance support for decision-making about antidepressant medication use in pregnancy may need to be tailored differently for pregnancy-planning and already pregnant women.
Linking reactive software to the X-Window System
Creators: name: Schulte, Wolfram
name: Vullinghs, Ton
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Graphical user interfaces (Computer systems)
subject: Tcl (Programming language)
subject: Tk toolkit
subject: X Window System (Computer system)
subject: Graphische Benutzeroberfläche
subject: X Window System 11

description: We discuss our experience with linking (existing) reactive applications to X11 based graphical user interfaces. For implementing the user interface we choose to use the Tcl/Tk toolkit, whereas the application itself may be written in any language (even a declarative one) that provides means to perform primitive I/O. The application and the graphical user interface run as separate processes and communicate in either a synchronous or asynchronous way using a bidirectional communication channel. The proposed approach separates software engineering concerns, is easy to use, is reasonably efficient and enables the linking of arbitrary languages to graphical user interfaces.
Combining Business Intelligence, Indicators, and the User Requirements Notation for Performance Monitoring
Creators: name: Johari Shirazi, Iman
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Performance Monitoring
Cognos
IBM Cognos Business Intelligence
IBM Cognos SDK
IBM Cognos mash up service
Business Analytics
report generation
jUCMNav
GRL
Goal oriented modelling
goal oriented modelling language
UCM
multi dimension modelling
data modelling
goal modelling
cognos report
KPI
indicator
User requirement notation
Combining Business Intelligence, Indicators, and the User Requirements Notation for Performance Monitoring
eclipse-based goal modelling tool
goal measurement
key performance indicator
goal oriented requirement language
automatic report generation
real time monitoring
business intelligence
integration with cognos
integration with Business Intelligence tool
software integration
goal strategy
SDK and soap
Rest mash up
cut training time

description: Organizations use Business Intelligence (BI) systems to monitor how well they are meeting their goals and objectives. Yet, very often BI systems do not include clear models of the organization’s goals or of how to measure whether they are satisfied or not. Several researchers now attempt to integrate goal models into BI systems, but there are still major challenges related to how to get access to the BI data to populate the part of the goal model (often indicators) used to assess goal satisfaction. This thesis explores a new approach to integrate BI systems with goal models. In particular, it explores the integration of IBM Cognos Business Intelligence, a leading BI tool, with an Eclipse-based goal modeling tool named jUCMNav. jUCMNav is an open source graphical editor for the User Requirements Notation (URN), which includes the Use Case Map notation for scenarios and processes and the Goal-oriented Requirement Language for business objectives. URN was recently extended with the concept of Key Performance Indicator (KPI) to enable performance assessment and monitoring of business processes. In jUCMNav, KPIs are currently calculated or modified manually. The new integration proposed in this thesis maps these KPIs to report elements that are generated automatically by Cognos based on the model defined in jUCMNav at runtime, with minimum effort. We are using IBM Cognos Mashup Service, which includes web services that enable the retrieval of report elements at the most granular level. This transformation provides managers and analysts with useful goal-oriented and process-oriented monitoring views fed by just-in-time BI information. This new solution also automates retrieving data from Cognos servers, which helps reducing the high costs usually caused by the amount of manual work required otherwise. The novel approach presented in this thesis avoids manual report generation and minimizes any contract with respect to the location of manually created reports, hence leading to better usability and performance. The approach and its tool support are illustrated with an ongoing example, validated with a case study, and verified through testing.
Delay analysis for a finite buffer TDMA model
Creators: name: Neuts, Marcel F.
name: Guo, Jun
name: Zukerman, Moshe
name: Vu, Hai
Publisher: name: Swinburne
Year: 2024

description: This paper provides an efficient solution for the derivation of the delay distribution for a TDMA system with a finite buffer. Assuming successive intervals of length equal to the duration of a slot, the density is expressed as (finite) linear combinations of gamma densities and beta densities with positive coefficients. The results are verified by simulations. Comparison with a previously proposed solution demonstrates that the solution presented here is more efficient.
Seismic Assessment of Unreinforced Masonry Buildings In Canada
Creators: name: Bélec, Gilbert
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Seismic assessment
Unreinforced masonry
Fragility curve
Incremental Dynamic Analysis
Time History Analysis

description: Unreinforced masonry (URM) structures have shown tobe susceptible to significant damage during strong earthquakes. Vulnerability assessment of URM buildings is needed so that appropriate mitigation strategies can be implemented. The existing Canadian practice consists of rapid seismic screening of buildings to assign priorities for further and more refined assessments, followed by refined analysis of individual critical buildings. The current seismic screening procedure, from 1992, is based on qualitative observations of seismic vulnerability, enabling the assignment of seismic priority indices, quantified on the basis of expert opinion and experience. More refined tools are needed for seismic vulnerability assessment of URM buildings in Canada, based on the current Canadian seismic hazard values. The objective of the research project is to fulfill these needs by developing fragility curves that provide a probabilistic assessment of different levels of building performance under different intensities ofeastern and western seismicity. Using an inventory of over 50,000 structures, a seismic assessment of typical low-rise and mid-rise URM structures located in eastern and western Canada was carried out. The required analyses were done using applied element method software which effectively modeled the in-plane and out-of-plane behaviour of masonry walls. Using incremental dynamic analysis, fragility curves were developed to reflect the capacity of URM structures with a wide variety of selected structural and ground motion parameters. The results were verified against available fragility information in the literature. They show the significance of selected parameters, while providing effective tools for seismic vulnerability assessment of URM buildings in eastern and western Canada.
Computational aspects in modelling electromagnetic field parameters in microstrips.
Creators: name: Chubukjian, Arto.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Electronics and Electrical.

description: This thesis introduces the results of a detailed investigation and analysis into the key aspects of the Vector Finite Element Method, the critical relationships between the VFEM zone discretization and the associated solution matrix equations, the discovery of the original fill-in laws and the fill-in prediction methods, and their impact on the computational aspects and processes. Furthermore, the work included the design and implementation of accelerated matrix solution models, and their successful implementation and application to various electromagnetic problems and the presentation of the excellent performance results obtained. Also, one of the problem examples used in the investigation contributed to the validation of a method to reduce the characteristic impedance of a microstrip by means of grooves. Finally, the modelling of the electromagnetic problems by Artificial Neural Networks, and the successful investigation of an original concept---training by decimation---led to the validation of Artificial Neural Networks as a real-time modelling tool which completed the work of this thesis.
Il giovane Tommaso e la grama sostanza
Creators: name: Spinelli, Luigi
Publisher: name: Doctor Virtualis
Year: 2008

description: Una proposta di lettura ";trascendentalista"; del ";De ente"; di Tommaso d'Aquino. Il venir meno dei presupposti per fondare un rapporto forte tra discorso e realtà.
description: Doctor Virtualis, N° 4 (2005): Dal Pra e il medioevo
Categorie, relazioni e metafore nell'Itinerarium mentis in Deum
Creators: name: Ferrara, Alfio
Publisher: name: Doctor Virtualis
Year: 2008

description: La metafora come strumento con il quale rinunciare a una teoria della definizione basata sulla sostanza, per preferire un linguaggio più evocativo. Metaphor as a tool by which giving up a substance based definition theory, in order to choose a more evocative language.
description: Doctor Virtualis, N° 5 (2006): Bonaventura da Bagnoregio: Filosofia, teologia, relazione
Structural and Functional Dissection of the MLL1 Histone Methyltransferase Complex
Creators: name: Avdic, Vanja
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: MLL1
Ash2L
WDR5
RbBP5
histone methylation
structural biology
x-ray crystallography

description: The mixed lineage leukemia (MLL) proteins regulate an array of developmental and differentiation processes. Similar to other members of the SET1 family, association of MLL1-4 with Ash2L, RbBP5 and WDR5, collectively termed the MLL core complex, is required for MLL mediated histone H3 Lys-4 di/tri-methylation. Each member of the core complex has a unique role in modulating the activity of MLL1. WDR5 is key in nucleating the formation of the core complex by acting as a structural scaffold, whereas Ash2L and RbBP5 are responsible for stimulating MLL methyltransferase activity. Currently, the structural and biochemical mechanisms utilized by the core complex to regulate MLL1 activity are unknown. Through structural and biochemical dissection of the core complex we have assigned specific functions to core complex subunits and have identified the minimal structural requirements for methyltransferase activity. Furthermore, through structure based drug design, we have identified a peptidomimetic inhibitor of MLL1 methyltransferase activity.
Supplementary document for Construction of Integrated Multi-layer Textile for Solar-driven Steam Generation - 5220745.pdf
Creators: name: Xie, Mengyu
name: Qian, Jiaqi
name: Li, Yao
name: Yang, Hanmei
name: QU, Jiangang
name: Hu, Xiaolin
name: Mao, Qinghui
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Thermal conductivity measurement; Evaporation efficiency calculation; Application photo; Water contact angles; The evaporation efficiencies; Comparison of materials in references; TGA of cotton fabric and RGO/cotton fabric.
Grossatesta e la matematica dell'infinito
Una lettura del Commento alla Fisica
Creators: name: Luce, Massimiliano
Publisher: name: Doctor Virtualis
Year: 2008

description: Un fondamento teologico per la matematica dell'infinito: Dio come primo matematico in grado di numerare gli infiniti punti delle grandezze geometriche. A theological foundation for the mathematics of the infinity: God as the first mathematician, who is able to number the endless points of the geometrical size.
description: Doctor Virtualis, N° 5 (2006): Bonaventura da Bagnoregio: Filosofia, teologia, relazione
Conditioning perspectives for primary immunodeficiency stem cell transplants
Creators: name: Shaw, Peter
name: Shizuru, Judith
name: Hönig, Manfred
name: Veys, Paul
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: chemotherapy
subject: immunoablation
subject: CHRONIC GRANULOMATOUS-DISEASE
subject: IMMUNE RECONSTITUTION
subject: MIXED CHIMERISM
subject: CHILDREN
subject: SURVIVAL
subject: DDC 610 / Medicine & health
subject: Hematopoietic stem cell transplantation
subject: Immunotherapy
subject: Neoplasms; Drug therapy
subject: Child
subject: Antibodies, Monoclonal
subject: Transplantation conditioning
subject: Treatment outcome
subject: Periphere Stammzellentransplantation
subject: Chemotherapie
subject: Immuntherapie
subject: Fludarabin
subject: Treosulfan

description: The majority of children undergoing Hematopoietic Stem cell Transplantation (HSCT) require conditioning therapy to make space and prevent rejection of the donor stem cells. The exception is certain children with Severe Combined immune deficiency, who have limited or no ability to reject the donor graft. Transplant conditioning is associated with significant morbidity and mortality from both direct toxic effects of chemotherapy as well as opportunistic infections associated with profound immunosuppression. The ultimate goal of transplant practice is to achieve sufficient engraftment of donor cells to correct the underlying disease with minimal short- and long-term toxicity to the recipient. Traditional combinations, such as busulfan and cyclophosphamide, achieve a high rate of full donor engraftment, but are associated with significant acute transplant-related-mortality and late effects such as infertility. Less “intensive” approaches, such as combinations of treosulfan or melphalan with fludarabine, are less toxic, but may be associated with rejection or low level chimerism requiring the need for re-transplantation. The major benefit of these novel approaches, however, which we hope will be realized in the decades to come, may be the preservation of fertility. Future approaches look to replace chemotherapy with non-toxic antibody conditioning. The lessons learnt in refining conditioning for HSCT are likely to be equally applicable to gene therapy protocols for the same diseases.
Book review: 'Creative destruction: why companies that are built to last underperform the market and how to successfully transform them', by Richard Foster and Sarah Kaplan
Creators: name: Friedman, Ken
Publisher: name: Swinburne
Year: 2024

description: Review of the book: 'Creative destruction: why companies that are built to last underperform the market and how to successfully transform them', by Richard Foster and Sarah Kaplan, published by Doubleday Currency, 2001.
Waldensianism and English Protestants: The Construction of Identity and Continuity
Creators: name: Goldberg-Poch, Mira
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Waldensian
Vaudois
Piedmont
Savoy
Protestant Identity
English International Relations
Heretics
Print Culture
Poor of Lyons
Reformation
Wars of Religion
Propaganda

description: In 1655 and again in 1686-1689, the Waldensians of Piedmont were massacred by the Duke of Savoy after he issued edicts forbidding the practice of their religion. The Waldensians were later followers of the medieval religious movement of the Poor of Lyons, declared heretical in 1215. The Waldensians associated with the Reformation in 1532, and thus formed a link with diverse groups of Protestants across Europe. In the periods immediately surrounding both massacres, an outpouring of publications dedicated to their plight, their history, and their religious identity appeared, a large number of which emerged in London. On both occasions, the propaganda gave rise to international sympathy and encouraged international intervention, eventually provoking the Duke to rescind the edicts that had instigated the massacres. While most contemporary scholars consider the Waldensians to have been fully absorbed into Protestantism after 1532, it is clear from the writings of both the Waldensians and their sympathizers that they considered themselves a separate entity: the inheritors of a long tradition of dissent from the Catholic Church based on their own belief in the purity of the Gospel. The Waldensian identity was based on a history of exclusion and persecution, and also on a belief that they had transmitted the true embodiment of Christianity through the centuries. The documents that were published surrounding the massacres address the legitimacy of the Waldensian identity based on centuries of practice. English and continental Protestants identified with the Waldensians, who provided ancient ties and legitimacy to their ‘new’ religion, and the Waldensians adopted that identity proudly, all the while claiming continuity. Protestants also used the Waldensians in propagandist documents, most often to justify political or religious actions and ideologies. The continuity of Waldensianism through the Reformation became crucially important for the wider umbrella of Protestantism as a legitimizing factor for the movement. This thesis investigates the claims of continuity and finds that while the Waldensians underwent a dramatic change in religious doctrine to conform to the Reformation, their belief in the continuity of their religious identity can be validated by examining religion from a socio-cultural perspective that takes aspects other than theology into consideration.
Can Landscape Composition Predict Movement Patterns and Site Occupancy by Blanding's Turtles?: A Multiple Scale Study in Québec, Canada
Creators: name: Fortin, Gabrielle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Emydoidea blandingii
Landscape composition
Home range size
Wetland occupancy
Habitat use
Modelling
Conservation

description: As habitat loss and fragmentation are major causes of decline in animal species, studying habitat requirements in these species is a key component of their recovery. I investigated the relationship between landscape composition and habitat use of Blanding’s turtles, Emydoidea blandingii, a freshwater turtle threatened by habitat loss and road mortality on most of its Canadian range. In 2010, I conducted a radio-telemetry survey of 44 Blanding’s turtles in southern Québec, Canada, and modelled their home range size from land cover proportions measured at many spatial scales. I also used data from a visual survey conducted in 2008 and 2009 to model wetland occupancy of the species at the landscape scale. Home range size of the Blanding’s turtle was significantly correlated to landscape composition, and the proportions of agriculture, open water and anthropogenic lands had the strongest relationships with home range size. However, those relationships were weak and the models were unable to predict home range size accurately. At the landscape scale, land cover and road density poorly predicted probability of occurrence, and Blanding’s turtles occupied wetlands in both disturbed and natural sites. Management of the species should focus on protecting sites of occurrence with high wetland density, low road density, and sufficient suitable habitat to cover their seasonal movement patterns.
Tommaso e la dottrina delle relazioni sussistenti
Creators: name: Bottarini, Giuseppe
Publisher: name: Doctor Virtualis
Year: 2008

description: La costruzione teologica come spazio dell'esperimento mentale. Una regolarità trascendentale per dare forma alla conoscibilità dell'esperienza. The theological construction as a space for mental experiment. A transcendental regularity to shape the experience understanding.
description: Doctor Virtualis, N° 5 (2006): Bonaventura da Bagnoregio: Filosofia, teologia, relazione
Sex differences in lymphoid follicles in COPD airways
Creators: name: Tam, Anthony
name: Tanabe, Naoya
name: Churg, Andrew
name: Wright, Joanne L.
name: Hogg, James C.
name: Sin, Don D.
Publisher: name: BioMed Central
Year: 2020

description: Background: Female smokers have increased risk for chronic obstructive pulmonary disease (COPD) compared with male smokers who have a similar history of cigarette smoke exposure. Tertiary lymphoid follicles are often found in the lungs of patients with severe COPD but sex-related differences have not been previously investigated. We determined the impact of female sex hormones on chronic cigarette smoke-induced expression of lymphoid aggregates in mice with COPD-like pathologies. Methods: Lymphoid aggregate counts, total aggregate cross-sectional area and foamy macrophage counts were determined morphometrically in male, female, and ovariectomized mice exposed to air or cigarette smoke for 6 months. B-cell activating factor (BAFF) protein expression and markers of oxidative stress were evaluated in mouse lung tissues by immunofluorescence staining and gene expression analyses. Quantitative histology was performed on lung tissue sections of human COPD lungs to evaluate follicle formation. Results: Lymphoid follicle and foamy macrophage counts as well as the total follicle cross-sectional area were differentially increased in lung tissues of female mice compared to male mice, and these differences were abolished by ovariectomy. These lymphoid aggregates were positive for CD45, CD20, CD21 and BAFF expression. Differential increases in Mmp12 and Cxcl2 gene expression correlated with an increase in foamy macrophages in parenchymal tissues of female but not male mice after smoke exposure. Parenchymal tissues from female mice failed to induce antioxidant-related genes in response to smoke exposure, and this effect was restored by ovariectomy. 3-nitrotyrosine, a stable marker of oxidative stress, positively correlated with Mmp12 and Cxcl2 gene expression. Hydrogen peroxide induced BAFF protein in mouse macrophage cell line. In human lung tissues, female smokers with severe COPD demonstrated increased numbers of lymphoid follicles compared with males. Conclusions: Chronic smoke exposure increases the risk of lymphoid aggregate formation in female mice compared with male mice, which is mediated female sex hormones and BAFF expression in an oxidative environment.
Presentazione
Creators: name: Parodi, Massimo
name: Selogna, Chiara
Publisher: name: Doctor Virtualis
Year: 2008

description: All'immagine che si fa problema corrisponde un movimento speculare di problemi che si fanno immagine. 
Il cinema può anche essere un modo per rappresentare questioni teoriche o addirittura dottrine filosofiche.
description: Doctor Virtualis, N° 6 (2007): Un medioevo per il cinema: Intentio, Fictio
Il Medioevo nei Macbeth cinematografici
Welles, Kurosawa, Polanski, Visconti
Creators: name: Bellocchio, Letizia
Publisher: name: Doctor Virtualis
Year: 2008

description: Dalla figura di Macbeth emerge l'idea di un'epoca crudele e violenta, che tende a esaltare gli aspetti brutali e malvagi dell'uomo.
description: Doctor Virtualis, N° 6 (2007): Un medioevo per il cinema: Intentio, Fictio
Aligning Leader Behaviors With Innovation Requirements Improves Performance: An Experimental Study
Creators: name: Gerlach, Friederike
name: Heinigk, Katharina
name: Rosing, Kathrin
name: Zacher, Hannes
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: innovation requirements
subject: opening leader behavior
subject: closing leader behavior
subject: creativity
subject: implementation
subject: 150
subject: Führung
subject: Verhalten
subject: Innovation
subject: Leistung
subject: Experiment

description: Gefördert durch den Publikationsfonds der Universität Kassel
Il medioevo di Francesco giullare di Dio
Creators: name: Subini, Tomaso
Publisher: name: Doctor Virtualis
Year: 2008

description: Francesco d'Assisi come spunto, nel film di Rossellini, per una riflessione sui temi della marginalità sociale e dell'anticonformismo.
description: Doctor Virtualis, N° 6 (2007): Un medioevo per il cinema: Intentio, Fictio
Lo straniamento ingenuo
Perceval le Gallois di Eric Rohmer
Creators: name: Dagna, Stella
Publisher: name: Doctor Virtualis
Year: 2008

description: Un medioevo esplicitamente finto, ricostruito in studio e rappresentato in modo quasi brechtiano.
description: Doctor Virtualis, N° 6 (2007): Un medioevo per il cinema: Intentio, Fictio
Language-based analysis of communicating finite state machines.
Creators: name: Huus, Jan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Computer Science.

description: Protocol validation has traditionally focused on detecting errors defined in terms of global states. A complementary approach is to analyze the process languages of a protocol, where a process language is defined as the set of executable event sequences of a process in the protocol. A general property of a process is "effectiveness", defined as the absence of unexecutable specified event sequences. A method is given for determining whether a specified process (the "host process") in a protocol is effective. The method involves generating a process language's finite state machine representation, called a process event graph (PEG). Every PEG node maps to a global state. Using the given method to generate a PEG, it is shown that, when the PEG generation does not detect error states, every reachable global state is reachable from a PEG node by an event sequence that does not include any host events. This introduces the possibility of a parallel approach to reachability analysis, in which a PEG is generated, and then a "local" reachability analysis is performed from each PEG node in parallel, ignoring host events. Other applications of PEGs are also given.