cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An LQR-assisted Control Algorithm for an Under-actuated In-pipe Robot in Water Distribution Systems
Creators: name: Kazeminasab, Saber
name: Jafari, Roozbeh
name: Banks, M. Katherine
Publisher: name: arXiv
Year: 2020
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: To address the operational challenges of in-pipe robots in large pipes of water distribution systems (WDS), in this research, a control algorithm is proposed for our previously designed robot [4]. Our size adaptable robot has an under-actuated modular design that can be used for both leak detection and quality monitoring. First, nonlinear dynamical governing equations of the robot are derived with the definition of two perpendicular planes, and two sets of states are defined for the robot for stabilization and mobilization. For stabilization, we calculated the auxiliary system matrices and designed a stabilizer controller based on the linear quadratic regulator (LQR) controller, and combined it with a proportional-integral-derivative (PID) based controller for mobilization. The controller scheme is validated with simulation in MATLAB in various operation conditions in three iterations. The simulation results show that the controller can stabilize the robot inside the pipe by converging the stabilizing states to zero and keeping them in zero with initial values between -25 degree and +25 degree and tracking velocities of 10cm/s, 30cm/s, and 50cm/s which makes the robot agile and dexterous for operation in pipelines.
Semantic elicitation: Bare noun interpretation
Creators: name: Koech, Nicholas Kipchumba
name: Bossi, Madeline
Publisher: name: California Language Archive, University of California, Berkeley
Year: 2021
Subjects: subject: tuy

description: One .mp4 file and one .pdf file. Elicitation of mass nouns and their various interpretations (e.g. generic, existential, definite).
A pedagogical derivation of dynamical susceptibilities
Creators: name: Nesselrodt, R. D.
name: Freericks, J. K.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Dynamical two-particle susceptibilites are important for a wide range of different experiments in condensed-matter physics and beyond. Nevertheless, most textbooks avoid describing how to derive such response functions, perhaps because they are viewed as too complex. In the literature, most derivations work with generalized susceptibilities, which are more general, but require an even higher layer of complexity. In this work, we show a more direct derivation in the context of model Hamiltonians which can be mapped directly onto an impurity model. We also present an alternative derivation for the irreducible vertex in the context of the Falicov-Kimball model.
description: 11 pages
Bosutinib: Pediatric First Approval
Creators: name: Hoy, Sheridan M.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine
Paediatrics
Cancer

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Sheridan M. Hoy is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here.
Abstract
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., is well established in the EU and the USA as a treatment for adults with newly diagnosed (ND) chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML), and for CP, accelerated phase and blast phase Ph+ CML that is resistant or intolerant (R/I) to prior therapy. In September 2023, based on clinical data from patients aged ≥ 1 to < 18 years, bosutinib was approved in the USA for the treatment of pediatric patients aged ≥ 1 year with CP Ph+ CML that is ND or R/I to prior therapy. This article summarizes the milestones in the development of bosutinib leading to this first pediatric approval.
© Springer Nature Switzerland AG 2023
Developing Entrepreneurial Skills through School Industry Links
Creators: name: ADAMS Omolola Taiwo
Publisher: name: Zenodo
Year: 2019

description: Learning should not only be theoretical but what we learnt should be practical. Learning should involve the acquisition of skills through practical involvement which can only be achieved through linking school with industry. This paper looks into the concept of entrepreneur and entrepreneurship education. It also looks into some strategies for inculcating entrepreneurial skills into youths so as to make them independent and, in the long run, become employers of labor. School link with industry allows students the opportunity of exploring firsthand real equipment and machinery in the industry where they are attached; the students are taught and are able to handle the instrument. Other methods of developing entrepreneurial skills are also highlighted.
Additional file 2 of Implant design affects walking and stair navigation after total knee arthroplasty: a double-blinded randomised controlled trial
Creators: name: Komaris, Dimitrios-Sokratis
name: Cheral Govind
name: Murphy, Andrew James
name: Clarke, Jon
name: Ewen, Alistair
name: Leonard, Hollie
name: Riches, Philip
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2:. Table 2 Knee kinetic parameters in stair descent.
Supersymmetric U(1) Gauge Realization of the Dark Scalar Doublet Model of Radiative Neutrino Mass
Creators: name: Ma, Ernest
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Adding a second scalar doublet (eta^+,eta^0) and three neutral singlet fermions N_{1,2,3} to the Standard Model of particle interactions with a new Z_2 symmetry, it has been shown that Re(eta^0) or Im(eta^0) is a good dark-matter candidate and seesaw neutrino masses are generated radiatively. A supersymmetric U(1) gauge extension of this new idea is proposed, which enforces the usual R parity of the Minimal Supersymmetric Standard Model, and allows this new Z_2 symmetry to emerge as a discrete remnant.
description: 8 pages, 3 figures
Deterministic Aspect of the $γ$-ray Variability in Blazars
Creators: name: Bhatta, Gopal
name: Pánis, Radim
name: Stuchlík, Zdeněk
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Linear time series analysis, mainly the Fourier transform based methods, has been quite successful in extracting information contained in the ever-modulating light curves (Lcs) of active galactic nuclei, and thereby contribute in characterizing the general features of supermassive black hole systems. In particular, the statistical properties of $γ$-ray variability of blazars are found to be fairly represented by flicker noise in the temporal frequency domain. However, these conventional methods have not been able to fully encapsulate the richness and the complexity displayed in the light curves of the sources. In this work, to complement our previous study on the similar topic, we perform non-linear time series analysis of the decade-long Fermi/LAT observations of 20 $γ$-ray bright blazars. The study is motivated to address one of the most relevant queries that whether the dominant dynamical processes leading to the observed $γ$-ray variability are of deterministic or stochastic nature. For the purpose, we perform Recurrence Quantification Analysis of the blazars and directly measure the quantities which suggest that the dynamical processes in blazar could be a combination of deterministic and stochastic processes, while some of the source light curves revealed significant deterministic content. The result with possible implication of strong disk-jet connection in blazars could prove to be significantly useful in constructing models that can explain the rich and complex multi-wavelength observational features in active galactic nuclei. In addition, we estimate the dynamical timescales, so called "trapping timescales", in the order of a few weeks.
description: ApJ accepted, 20 pages and 6 figures
On SIC-POVMs in Prime Dimensions
Creators: name: Flammia, Steven T.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The generalized Pauli group and its normalizer, the Clifford group, have a rich mathematical structure which is relevant to the problem of constructing symmetric informationally complete POVMs (SIC-POVMs). To date, almost every known SIC-POVM fiducial vector is an eigenstate of a "canonical" unitary in the Clifford group. I show that every canonical unitary in prime dimensions p > 3 lies in the same conjugacy class of the Clifford group and give a class representative for all such dimensions. It follows that if even one such SIC-POVM fiducial vector is an eigenvector of such a unitary, then all of them are (for a given such dimension). I also conjecture that in all dimensions d, the number of conjugacy classes is bounded above by 3 and depends only on d mod 9, and I support this claim with computer computations in all dimensions < 48.
description: 6 pages, no figures. v3 Refs added, improved discussion of previous work. Ref to a proof of the main conjecture also added
Additional file 2 of Development of key quality indicators for appropriate antibiotic use in the Republic of Korea: results of a modified Delphi survey
Creators: name: Bongyoung Kim
name: Lee, Myung Jin
name: Park, Se Yoon
name: Moon, Song Mi
name: Kyoung-Ho Song
name: Kim, Tae Hyong
name: Eu Suk Kim
name: Kim, Hong Bin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Table 1: Final list of 21 articles selected after a systematic literature search.
Forgery Blind Inspection for Detecting Manipulations of Gel Electrophoresis Images
Creators: name: Shao, Hao-Chiang
name: Cheng, Ya-Jen
name: Duh, Meng-Yun
name: Lin, Chia-Wen
Publisher: name: arXiv
Year: 2020
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Recently, falsified images have been found in papers involved in research misconducts. However, although there have been many image forgery detection methods, none of them was designed for molecular-biological experiment images. In this paper, we proposed a fast blind inquiry method, named FBI$_{GEL}$, for integrity of images obtained from two common sorts of molecular experiments, i.e., western blot (WB) and polymerase chain reaction (PCR). Based on an optimized pseudo-background capable of highlighting local residues, FBI$_{GEL}$ can reveal traceable vestiges suggesting inappropriate local modifications on WB/PCR images. Additionally, because the optimized pseudo-background is derived according to a closed-form solution, FBI$_{GEL}$ is computationally efficient and thus suitable for large scale inquiry tasks for WB/PCR image integrity. We applied FBI$_{GEL}$ on several papers questioned by the public on \textbf{PUBPEER}, and our results show that figures of those papers indeed contain doubtful unnatural patterns.
description: This version is an extension of Prof. Shao's previous conference paper (IEEE GlobalSIP 2018): "Unveiling Vestiges of Man-Made Modifications on Molecular-Biological Experiment Images." (https://doi.org/10.1109/GlobalSIP.2018.8646594)
Evolution of V838 Monocerotis during and after the 2002 eruption
Creators: name: Tylenda, R.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: By fitting the available photometric data on V838 Mon with standard supergiant spectra we have derived principal stellar parameters, i.e. effective temperature, radius and luminosity, and followed the evolution of the object since its discovery in early January 2002. Our analysis shows that the 2002 outburst of V838 Mon consisted of two major phases: pre-eruption which was observed in January 2002 and a major outburst, called eruption, which started in the beginning of February 2002. During pre-eruption the object seemed to be relaxing after an initial event which had presumably taken place in last days of December 2001. The eruption phase, which lasted till mid-April 2002, resulted from a very strong energy burst, which presumably took place in last days of January at the base of the stellar envelope inflated in pre-eruption. The burst produced an energy wave, which was observed as a strong luminosity flash in the beginning of February, followed by a strong mass outflow in form of two shells, which was observed as an expanding photosphere in later epochs. In mid-April, when the outflow became optically transparent and most of its energy radiated away, the object entered the decline phase during which V838 Mon was evolving along the Hayashi track. This we interpret as an evidence that the main energy source during decline was due to gravitational contraction of the object envelope inflated in eruption. Late in 2002 a dust formation started in the expanding shells which gave rise to a strong infrared excess observed in 2003.
description: 14 pages, 4 figures, 2 tables, accepted in Astronomy & Astrophysics
Eulerian-Lagrangian modelling of bio-aerosols irradiated by UV-C light in relation to SARS-CoV-2 transmission
Creators: name: D'Alessandro, V.
name: Falone, M.
name: Giammichele, L.
name: Ricci, R.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Medical Physics (physics.med-ph)
subject: FOS: Physical sciences
subject: J.2; I.6

description: It is well known that several viruses, as well as SARS-CoV-2, can be transmitted through airborne diffusion of saliva micro-droplets. For this reason many reserach groups have been devoted their efforts in order to gain new insight into the transport of fluids and particles originted from human respiratory tracts. This paper aims to provide a contribution to the numerical modelling of bio-aerosols. In particular, the well-known problem around the safety distance to be held for avoiding virus transmission in the absence of external wind is further investigated. Thus, new indexes capable of evaluating the contamination risk are introduced and the possibility to inactivate virus particles by means of an external UV-C radiation source is studied. For this purpose, a new model which takes into account biological inactivation deriving from UV-C exposure in a Eulerian-Lagrangian framework is presented.
description: 12 pages, 23 figures. It will be submitted to Physics of Fluids
Additional file 3 of Development of key quality indicators for appropriate antibiotic use in the Republic of Korea: results of a modified Delphi survey
Creators: name: Bongyoung Kim
name: Lee, Myung Jin
name: Park, Se Yoon
name: Moon, Song Mi
name: Kyoung-Ho Song
name: Kim, Tae Hyong
name: Eu Suk Kim
name: Kim, Hong Bin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Table 2: Title and affiliations of expert panels.
New Zealand's offshore sedimentary basins - supplementary data files
Creators: name: Bland, Kyle
name: Strogen, Dominic
name: Arnot, Malcolm
name: Viskovic, G. Paul D
name: Sahoo, Tusar
name: Seebeck, Hannu
name: Kellett, Richard
name: Bull, Suzanne
name: Thrasher, Glenn Paul
name: Kroeger, Karsten F
name: Lawrence, Mark
name: Griffin, Angela
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 370509
subject: Sedimentology
classificationCode: 370510
subject: Stratigraphy (incl. biostratigraphy, sequence stratigraphy and basin analysis)
classificationCode: 370511
subject: Structural geology and tectonics
classificationCode: 370599
subject: Geology not elsewhere classified
classificationCode: 370504
subject: Marine geoscience
classificationCode: 370508
subject: Resource geoscience

description: These documents and files contains additional descriptions of the geological fill within sedimentary basins described in the journal paper ‘New Zealand’s offshore sedimentary basins’, published in the New Zealand Journal of Geology and Geophysics. The data presented herein are primarily derived from regional-scale assessments of New Zealand’s major offshore sedimentary basins, undertaken as part of the Atlas of Petroleum Prospectivity research programme.
Virtual IED sensor for df rf CCP discharges
Creators: name: Bogdanova, M.
name: Lopaev, D.
name: Rakhimova, T.
name: Voloshin, D.
name: Zotovich, A.
name: Zyryanov, S.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Ion-assisted surface processes are the basis of modern plasma processing. Ion energy distribution (IED) control is critical for precise material modification, especially in atomic-level technologies such as atomic layer etching. Since this control should be done in real time, it requires real-time feedback using fast process sensors. In the general case of an industrial plasma reactor, when direct IED measurement is not possible, the IED can be estimated using the concept of a virtual IED sensor. In this paper, a similar virtual IED sensor is considered using an asymmetric dual-frequency (df) rf CCP discharge as an example. It is based on a fast calculation method of the IED at an rf-biased electrode. This approach uses the experimentally measured sheath voltage waveform and plasma density (or ion flux) as input data, and also includes Monte-Carlo simulation of ion motion in the sheath to take into account the effect of ion-neutral collisions. To validate this approach, experiments were carried out using various plasma diagnostics in several gases: argon and xenon as examples of plasma with atomic ions and nitrogen as an example of plasma with molecular ions. It is shown that in all cases it is possible to obtain an adequate IED estimation, close to the experimental one, in a reasonably short time (~ tens of seconds when using a modern PC). The results obtained demonstrate the possibility of using a virtual IED sensor in real plasma processing.
Real scalar phase transitions: a nonperturbative analysis
Creators: name: Gould, Oliver
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the thermal phase transitions of a generic real scalar field, without a $Z_2$-symmetry, referred to variously as an inert, sterile or singlet scalar, or $ϕ^3+ϕ^4$ theory. Such a scalar field arises in a wide range of models, including as the inflaton, or as a portal to the dark sector. At high temperatures, we perform dimensional reduction, matching to an effective theory in three dimensions, which we then study both perturbatively to three-loop order and on the lattice. For strong first-order transitions, with large tree-level cubic couplings, our lattice Monte-Carlo simulations agree with perturbation theory within error. However, as the size of the cubic coupling decreases, relative to the quartic coupling, perturbation theory becomes less and less reliable, breaking down completely in the approach to the $Z_2$-symmetric limit, in which the transition is of second order. Notwithstanding, the renormalisation group is shown to significantly extend the validity of perturbation theory. Throughout, our calculations are made as explicit as possible so that this article may serve as a guide for similar calculations in other theories.
description: 43 pages, 14 figures
Momentum space topology and quantum phase transitions
Creators: name: Volovik, G. E.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Many quantum condensed-matter systems, and probably the quantum vacuum of our Universe, are strongly correlated and strongly interacting fermionic systems, which cannot be treated perturbatively. However, physics which emerges in the low-energy does not depend on the complicated details of the system and is relatively simple. It is determined by the nodes in the fermionic spectrum, which are protected by topology in momentum space (in some cases, in combination with the vacuum symmetry). Here we illustrate this universality on some examples of quantum phase transitions, which can occur between the vacua with the same symmetry but with diferent topology in momentum space. The quantum phase transitions between the fully gapped states with different momentum-space topology are also discussed.
description: 55 pages, 13 figures, extended and references added
title: Was bleibt. „Last Folio. Spuren jüdischen Lebens in der Slowakei“. Ein Projekt von Yuri Dojc & Katya Krausova
Creators: name: Berthold, Judith
Publisher: name: ZZF - Centre for Contemporary History: Visual History
Year: 2015

description: Vom 24. April bis zum 1. August 2015 zeigt die Staatsbibliothek zu Berlin, unterstützt von Bertelsmann, die Ausstellung „Last Folio. Spuren jüdischen Lebens in der Slowakei“. 32 großformatige Fotografien des slowakisch-kanadischen Fotografen Yuri Dojc sind im Foyer der Staatsbibliothek in der Potsdamer Straße arrangiert. Die britische Filmemacherin Katya Krausova hat die Ausstellung kuratiert. Ob das Foyer der geeignete Ort ist, um die Bilder in Ruhe zu betrachten und auf sich wirken zu lassen, sei dahingestellt – auf jeden Fall muss man an ihnen vorbei. Auf dem Weg zur Ausleihe nimmt man sie zunächst nur aus den Augenwinkeln wahr. Auf dem Rückweg jedoch überwiegt die Neugier. Was ist auf den Bildern eigentlich zu sehen? Verlassene Räume, Bücher, die sich auflösen – nicht alles lässt sich sofort zuordnen.
Formation of Ultra-Short-Period Planets by Obliquity-Driven Tidal Runaway
Creators: name: Millholland, Sarah
name: Spalding, Christopher
Publisher: name: arXiv
Year: 2020
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Small, rocky planets have been found orbiting in extreme proximity to their host stars, sometimes down to only $\sim 2$ stellar radii. These ultra-short-period planets (USPs) likely did not form in their present-day orbits, but rather migrated from larger initial separations. While tides are the probable cause of this migration, the tidal source has remained uncertain. Here we introduce planetary obliquity tides as a natural pathway for the production of USPs within close-in multi-planet systems. The crucial idea is that tidal dissipation generally forces planetary spin vectors to equilibrium configurations called "Cassini states", in which the planetary obliquities (axial tilts) are non-zero. In these cases, sustained tidal dissipation and inward orbital migration are inevitable. Migration then increases the obliquity and strengthens the tides, creating a positive feedback loop. Thus, if a planet's initial semi-major axis is small enough ($a \lesssim 0.05$ AU), it can experience runaway orbital decay, which is stalled at ultra-short orbital periods when the forced obliquity reaches very high values ($\sim 85^{\circ}$) and becomes unstable. We use secular dynamics to outline the parameter space in which the innermost member of a prototypical Kepler multiple-planet system can become a USP. We find that these conditions are consistent with many observed features of USPs, such as period ratios, mutual inclinations, and occurrence rate trends with stellar type. Future detections of stellar obliquities and close-in companions, together with theoretical explorations of the potential for chaotic obliquity dynamics, can help constrain the prevalence of this mechanism.
description: 24 pages, 11 figures. Accepted to ApJ
Nonvanishing Energy Scales at the Quantum Critical Point of CeCoIn5
Creators: name: Paglione, Johnpierre
name: Tanatar, M. A.
name: Hawthorn, D. G.
name: Ronning, F.
name: Hill, R. W.
name: Sutherland, M.
name: Taillefer, Louis
name: Petrovic, C.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Heat and charge transport were used to probe the magnetic field-tuned quantum critical point in the heavy-fermion metal CeCoIn$_5$. A comparison of electrical and thermal resistivities reveals three characteristic energy scales. A Fermi-liquid regime is observed below $T_{FL}$, with both transport coefficients diverging in parallel and $T_{FL}\to 0$ as $H\to H_c$, the critical field. The characteristic temperature of antiferromagnetic spin fluctuations, $T_{SF}$, is tuned to a minimum but {\it finite} value at $H_c$, which coincides with the end of the $T$-linear regime in the electrical resistivity. A third temperature scale, $T_{QP}$, signals the formation of quasiparticles, as fermions of charge $e$ obeying the Wiedemann-Franz law. Unlike $T_{FL}$, it remains finite at $H_c$, so that the integrity of quasiparticles is preserved, even though the standard signature of Fermi-liquid theory fails.
description: 4 pages, 4 figures (published version)
Deucravacitinib: First Approval
Creators: name: Hoy, Sheridan M.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine
Rheumatology and Arthritis

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Sheridan M. Hoy is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here. 
Abstract
Deucravacitinib (SOTYKTU™) is a first-in-class, highly selective, oral tyrosine kinase 2 (TYK2) inhibitor. It acts via an allosteric mechanism, binding to the catalytically inactive pseudokinase regulatory domain of TYK2 and stabilizing an inhibitory interaction between the regulatory and catalytic domains. Deucravacitinib is being developed by Bristol Myers Squibb for the treatment of multiple immune-mediated diseases, including psoriasis, psoriatic arthritis, lupus and inflammatory bowel disease. It received its first approval (in the USA on 9 September 2022) for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. On 26 September 2022, it was subsequently approved in Japan for the treatment of plaque psoriasis, generalized pustular psoriasis and erythrodermic psoriasis. The Marketing Authorisation Application for deucravacitinib for the treatment of adults with moderate to severe plaque psoriasis has been validated in the EU, and clinical development of the drug for the treatment of multiple immune-mediated diseases is underway in numerous countries worldwide. This article summarizes the milestones in the development of deucravacitinib leading to this first approval for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
© Springer Nature Switzerland AG 2022
Non-elitist Evolutionary Multi-objective Optimizers Revisited
Creators: name: Tanabe, Ryoji
name: Ishibuchi, Hisao
Publisher: name: arXiv
Year: 2020
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Since around 2000, it has been considered that elitist evolutionary multi-objective optimization algorithms (EMOAs) always outperform non-elitist EMOAs. This paper revisits the performance of non-elitist EMOAs for bi-objective continuous optimization when using an unbounded external archive. This paper examines the performance of EMOAs with two elitist and one non-elitist environmental selections. The performance of EMOAs is evaluated on the bi-objective BBOB problem suite provided by the COCO platform. In contrast to conventional wisdom, results show that non-elitist EMOAs with particular crossover methods perform significantly well on the bi-objective BBOB problems with many decision variables when using the unbounded external archive. This paper also analyzes the properties of the non-elitist selection.
description: This is an accepted version of a paper published in the proceedings of GECCO 2019
Additional file 1 of Changes over time in HIV testing and counselling uptake and associated factors among youth in Zambia: a cross-sectional analysis of demographic and health surveys from 2007 to 2018
Creators: name: Heri, Aimé Bitakuya
name: Cavallaro, Francesca L.
name: Nurilign Ahmed
name: Musheke, Maurice Mubuyaeta
name: Matsui, Mitsuaki
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1: Table S1. Details on variables used for the analysis; Table S2. Determinants of HIV testing uptake among sexually active non-pregnant young women aged 15–24, Zambia 2018 DHS (N = 2457); and Table S3. Determinants of HIV testing uptake among sexually active young men aged 15–24, Zambia DHS 2018 (N = 3114).
"Komm herüber und hilf uns (Apg 16,9) - Atheismus, Indifferenz und christliche Verkündigung"
Publisher: name: Ökumenische Rundschau
Year: 2025

description: Ökumenische Rundschau, Bd. 41 Nr. 2 (1992): Ökumenische Rundschau, Band 41, Heft 2
Rubrics for Charge Conserving Current Mapping in Finite Element Particle in Cell Methods
Creators: name: Crawford, Zane D.
name: O'Connor, Scott
name: Luginsland, John
name: Shanker, B.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Modeling of kinetic plasmas using electromagnetic particle in cell methods (EM-PIC) is a problem that is well worn, in that methods developed have been used extensively both understanding physics and exploiting them for device design. EM-PIC tools have largely relied on finite difference methods coupled with particle representations of the distribution function. Refinements to ensure consistency and charge conservation have largely been an ad-hoc efforts specific to finite difference methods. Meanwhile, solution methods for field solver have grown by leaps and bounds with significant performance metrics compared to finite difference methods. Developing new EM-PIC computational schemes that leverage modern field solver technology means re-examining analysis framework necessary for self-consistent EM-PIC solution. In this paper, we prescribe general rubrics for charge conservation, demonstrate how these are satisfied in conventional finite difference PIC as well as finite element PIC, and prescribe a novel charge conserving finite element PIC. Our effort leverages proper mappings on to de-Rham sequences and lays a groundwork for understanding conditions that must be satisfied for consistency. Several numerical results demonstrate the applicability of these rubrics.
Non-monotonic pseudo-gap in high-Tc cuprates
Creators: name: Kordyuk, A. A.
name: Borisenko, S. V.
name: Zabolotnyy, V. B.
name: Schuster, R.
name: Inosov, D. S.
name: Follath, R.
name: Varykhalov, A.
name: Patthey, L.
name: Berger, H.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The mechanism of high temperature superconductivity is not resolved for so long because the normal state of cuprates is not yet understood. Here we show that the normal state pseudo-gap exhibits an unexpected non-monotonic temperature dependence, which rules out the possibility to describe it by a single mechanism such as superconducting phase fluctuations. Moreover, this behaviour, being remarkably similar to the behaviour of the charge ordering gap in the transition-metal dichalcogenides, completes the correspondence between these two classes of compounds: the cuprates in the PG state and the dichalcogenides in the incommensurate charge ordering state reveal virtually identical spectra of one-particle excitations as function of energy, momentum and temperature. These results suggest that the normal state pseudo-gap, which was considered to be very peculiar to cuprates, seems to be a general complex phenomenon for 2D metals. This may not only help to clarify the normal state electronic structure of 2D metals but also provide new insight into electronic properties of 2D solids where the metal-insulator and metal-superconductor transitions are considered on similar basis as instabilities of particle-hole and particle-particle interaction, respectively.
Developing micro-finance institutions in Vietnam: implications for establishing an enabling regulatory environment
Creators: name: Fallavier, Pierre
Publisher: name: University of British Columbia
Year: 2009

description: Based on results from a three-month field trip in the poorest regions of Vietnam, and on an extensive review of the literature, this thesis analyzes the current state of the micro-finance sector in Vietnam in terms of practices used by micro-finance institutions (MFIs) and in terms of the characteristics and needs of the regulatory environment they evolve in. The thesis identifies the conditions that constitute an "enabling environment" for sound MFIs on the basis of a review of international case studies and analysis. The literature review also leads to the development of a definition of poverty as "an exclusion from society and its productive systems, rooted in a lack of choices and opportunities", and human development as "the goal and process of enlarging people's choices". It explains how developing access to adequate microfinancial services can allow the poor to create micro-enterprises, accumulate saving, and increase their standards of living. A set of criteria for determining the soundness of micro-financial programs is developed, and the characteristics of a regulatory enabling environment that can facilitate the efficient operations of a wide network of local MFIs are pointed. It then presents a picture of current poverty eradication strategies and MFI practices in Vietnam, and of the regulatory environment MFIs evolve in. It then analyzes those findings in the light of the sound practices generated from the review of international experience. A set of implications is derived that reviews to which degree (i) Vietnam's national micro-finance strategy should be re-oriented to promote the creation or formalization of MFIs and allow them to operate on a market-pricing base; (ii) the Government should adapt the practices of its Bank for the Poor to fit international sound practices, and should use its wide outreach potential to disseminate such practices among local MFIs; (iii) a consultative process between all relevant actors should be undertaken to devise an appropriate set of regulations to govern formal MFIs and create a supervisory framework adapted to the characteristics of MFIs; and (iv) better use should be made of the existing micro-finance capacity by developing linkages between all players.
Charged Lepton Corrections to Neutrino Mixing Angles and CP Phases Revisited
Creators: name: Antusch, Stefan
name: King, Steve F.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We re-analyze charged lepton corrections to neutrino mixing angles and CP phases, carefully including CP phases from the charged lepton sector. We present simple analytical formulae for including the charged lepton corrections and derive compact new results for small neutrino and charged lepton mixings $θ^ν_{13}$ and $θ^{e}_{13}$. We find a generic relation $θ_{12} + \frac{1}{\sqrt{2}} θ^{e}_{12} \cos(δ- π) \approx θ^ν_{12}$, which relates the prediction from the neutrino sector $θ^ν_{12}$ to the charged lepton mixing $θ^{e}_{12}$ and to the MNS neutrino oscillation phase $δ$. We apply our formula to the examples of bimaximal or tri-bimaximal neutrino mixing. One implication is that the so-called quark-lepton complementarity relation $θ_{12} + θ_C = 45^\circ$ can only hold for $δ= π$ and it gets modified in the presence of leptonic CP violation. On the other hand, the lepton mixing $θ_{13}$ generated from the charged lepton correction $θ^{e}_{12}$ is independent of CP phases and given by $θ_{13} = \frac{1}{\sqrt{2}} θ^{e}_{12}$. Combining these results leads to a model-independent sum rule: $θ_{12} + θ_{13} \cos(δ- π) \approx θ^ν_{12}$ where $θ^ν_{12} = (35.26^\circ) 45^\circ$ in the case of (tri-)bimaximal neutrino mixing, for example.
description: 10 pages, references added and minor changes in the text
Semantic elicitation: Modality
Creators: name: Kipkoech, Linus
name: Bossi, Madeline
Publisher: name: California Language Archive, University of California, Berkeley
Year: 2021
Subjects: subject: sgc

description: Four .wav files (I with lavalier mic, M with in-recorder mic). See Notebook 3 (file bundle 2019-26.003). Elicitation of various types of modality.
Additional file 1 of Multizonal anogenital neoplasia in women: a cohort analysis
Creators: name: Albuquerque, Andreia
name: Godfrey, Michelle A. L.
name: Cappello, Carmelina
name: Pesola, Francesca
name: Bowring, Julie
name: Cuming, Tamzin
name: Masi, Anke De
name: Rosenthal, Adam N.
name: Sasieni, Peter
name: Nathan, Mayura
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. study flowchart.
Effects of Intercropping Celosia, Amaranthus and Corchorus on the Growth and Yield of Cucumber (Cucumis Sativus L.).
Creators: name: Akinkuoroye, Omowumi Hannah
Publisher: name: Zenodo
Year: 2019

description: Intercropping is the growing of two or more crops in close proximity to promote interaction between them. Intercropping has the advantage of increasing crop productivity. It could, however, lower the yield of one or more of the component crops. Two field experiments were conducted in IDO Local Government Area of Oyo State to evaluate effects of intercropping celosia, Amaranthus and Corchorus on the growth and yield of cucumber (Cucumis sativus L.). Cucumber seeds were sown at the rate of one seed per hole and spaced at 0.8 m x 1.0 m resulting in 12,500 plants per hectare while the seeds of celosia, Amaranthus and Corchorus were broadcast on the bed at the rate of 6 kg per hectare. Data were collected on vine length (cm), number of leaves between 2 and 6 weeks after sowing, number of fruits and fruit weight (kg) of cucumber at two major harvests, weed biomass, celosia, Amaranthus and Corchorus biomass yield at 7 Week After Sowing (WAS). The data were subjected to analysis of variance system while significant means were compared using the Least Significant Difference (LSD). The results showed that intercropping Celosia, Amaranthus and Corchorus with Cucumber did not have significant effects on the growth parameters such as the vine length and number of leaves but significantly affected the yield of cucumber in terms of the number of fruits and weight of fruits. The cumulative number and weight of fruits of cucumber intercropped with celosia were significantly lower than that of sole cucumber in the two croppings. The differences in yield among cucumber intercrops with the three vegetables were however not significant. Amaranthus, Corchorus, and Celosia caused 12, 18 and 30% reduction in the number of the fruit of cucumber respectively while the corresponding reduction in fruit yield were 18, 21 and 31%. Celosia appeared to have higher yield reduction effects on the cucumber than other leafy vegetables, thus care must be taken in choosing the associated crops.
Feasibility of low energy radiative capture experiments at the LUNA underground accelerator facility
Creators: name: Bemmerer, D.
name: Confortola, F.
name: Lemut, A.
name: Bonetti, R.
name: Broggini, C.
name: Corvisiero, P.
name: Costantini, H.
name: Cruz, J.
name: Formicola, A.
name: Fulop, Zs.
name: Gervino, G.
name: Guglielmetti, A.
name: Gustavino, C.
name: Gyurky, Gy.
name: Imbriani, G.
name: Jesus, A. P.
name: Junker, M.
name: Limata, B.
name: Menegazzo, R.
name: Prati, P.
name: Roca, V.
name: Rogalla, D.
name: Rolfs, C.
name: Romano, M.
name: Alvarez, C. Rossi
name: Schumann, F.
name: Somorjai, E.
name: Straniero, O.
name: Strieder, F.
name: Terrasi, F.
name: Trautvetter, H. P.
name: Vomiero, A.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The LUNA (Laboratory Underground for Nuclear Astrophysics) facility has been designed to study nuclear reactions of astrophysical interest. It is located deep underground in the Gran Sasso National Laboratory, Italy. Two electrostatic accelerators, with 50 and 400 kV maximum voltage, in combination with solid and gas target setups allowed to measure the total cross sections of the radiative capture reactions $^2$H(p,$γ$)3He and $^{14}$N(p,$γ$)$^{15}$O within their relevant Gamow peaks. We report on the gamma background in the Gran Sasso laboratory measured by germanium and bismuth germanate detectors, with and without an incident proton beam. A method to localize the sources of beam induced background using the Doppler shift of emitted gamma rays is presented. The feasibility of radiative capture studies at energies of astrophysical interest is discussed for several experimental scenarios.
description: Submitted to Eur. Phys. J. A
Adsorption of a fabric conditioner on cellulose nanocrystals: Synergistic effects of surfactant vesicles and polysaccharides on softness properties
Creators: name: Oikonomou, Evdokia K.
name: Messina, Grazia M. L.
name: Heux, Laurent
name: Marletta, Giovanni
name: Berret, Jean-François
Publisher: name: arXiv
Year: 2020
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Concentrated fabric conditioners are water-based formulations containing 10 wt. % of cationic surfactants that are deposited on textile fibers during the rinse cycle in a washing machine to make them smoother and softer to touch. In topical formulations, the concentration of cationic surfactants is reduced by half, this reduction being compensated by the addition of environment-friendly polysaccharides. Using atomic force microscopy (AFM), quartz crystal microbalance with dissipation (QCM-D) and ellipsometry, the deposition of formulations with or without polysaccharides on model cellulose substrates is studied. We found that 180 nm long cellulose nanocrystals (CNCs) deposited by spin-coating on amorphous silicon dioxide or on quartz crystal sensors provide a good model of cellulose surfaces. QCM-D results reveal strong electrostatic interactions of the surfactant vesicles and polysaccharides with the CNC layer. In the presence of polysaccharides, the adsorbed quantities are less (by 60%) than the sum of the respective amounts of each component, the structure of the interface being however more homogenous and rigid. This outcome suggests that surface techniques coupled with CNC coated substrates are promising for studying interactions of current formulations with cellulose surfaces.
description: 21 pages 5 figures
GABAC: an arithmetic coding solution for genomic data
Creators: name: Paridaens, Tom
name: Voges, Jan
name: Hernaez, Mikel
name: Fostier, Jan
name: Ostermann, Jörn
Publisher: name: F1000 Research Limited
Year: 2019

description: In an effort to provide a response to the ever-expanding generation of genomic data, ISO is designing a new solution for the representation, compression, and management of genomic sequencing data: the MPEG-G standard. This standard specifies an abstract representation of sequencing data and offers support for, among others, multi-dimensional random access, extensive meta-data annotation, data and privacy protection, data storage and streaming. We propose the first baseline implementation of an MPEG-G compliance entropy encoder/decoder: GABAC. It combines proven coding technologies, such as context-adaptive binary arithmetic coding, binarization schemes, and transformations into one straightforward solution. We tested GABAC on a test set of 206 descriptor stream files and compared it to the codecs used in the CRAM framework: gzip, bzip2, xz, rANS order-0, and rANS order-1. CABAC offers, on average, the highest compression ratio across all coding solutions (yielding the smallest compressed size among all 6 codecs for 127 out of 206 test items), while being, on average, 5.5 times faster than the second best compressor in compression time. Additionally, adding GABAC to the CRAM set of encoders would offer a slight compression gain, but, more importantly, significant speed-up improvement of a factor of 2.4 in compression time.