<b><i>Physiological Function of </i></b><b><i>Cyclic Nucleotide</i></b><b> </b><b><i>Phosphodiesterases in Atrial Myocytes and their Potential as Therapeutic Targets for Atrial Fibrillation</i></b>
Creators: name: J. Read, Matthew
name: Koschinski, Andreas
name: Bose, Samuel
name: Burton, REBECCA
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 320101
subject: Cardiology (incl. cardiovascular diseases)
classificationCode: 320199
subject: Cardiovascular medicine and haematology not elsewhere classified

description: <b>Supplementary Table 1. RNA sequencing data from Axol’s matured hiPSC derived cardiomyocytes used to create Table 3. </b><i>RNA was extracted using Qiagen RNEasy Mini kits, strand specific libraries were prepared using Illumina mRNA library kits and then sequenced with 150bp paired-end read on NovaSeq6000. Sequenced data was then normalised by transcripts per millions to give the values shown. </i><i>T</i><i>he creation and use of Axol's iPSC-derived cardiomyocytes was in accordance with all relevant ethical requirements.</i>Supplementary Discussion: We have performed the following search on clinical trials.gov:<b>Condition/Disease: Atrial Fibrillation OR Atrial Fibrillation OR AF OR Atrial Fibrillation Persistent OR Atrial Fibrillation New Onset OR Atrial Fibrillation Paroxysmal OR Atrial Flutter OR Atrial Tachycardia | Intervention/Treatment: Phosphodiesterase Inhibitors OR phosphodiesterase type 5 inhibitor OR Phosphodiesterase 5 Inhibitor OR Phosphodiesterase type 5 Inhibitor OR PDE5 OR PDE5 inhibitor OR PDE5i arm OR PDE5 Inhibitor OR PDE5- inhibitors group OR PDE5 inhibitor OR tadafil OR PDE9i OR Vardenafil OR Levitra OR BAY38-9456 OR Vardenafil ODT OR STAXYN OR BAY38-9456 OR Vardenafil 10mg OR Vardenafil Oral Tablet OR Vinpocetine OR ITI-214 OR PF-05180999 OR PF-05180999 Tablets OR pf 05180999 OR Milrinone OR Cilostazol OR Cilostazol 100 mg OR Cilostazol 100mg OR Enoximone OR Rolipram OR Roflumilast OR Rofluminlast cream OR Roflumilast Cream 0.15% OR Roflumilast 500 Mcg Oral Tablet OR sildenafil OR Sildenafil Citrate OR Sildenafil 50 mg OR sildenafil ODT OR Sildenafil 100 mg OR tadafil OR Avanafil OR avanafil 200mg OR Avanafil 50 MG OR Avanafil 50 MGOR Avanafil 100 mg OR Avanafil 200 mg OR udenafil OR Udenafil OR Zydena OR Udenafil 50 mg OR Udenafil 150 mg OR Udenafil 100 mg OR TP10 OR Doxofylline OR Ibudilast OR Ibudilast 50mg OR Ibudilast 20mg OR Apremilast OR Apremilast 30mg OR Apremilast 20mg OR Apremilast OR CC-10004 OR Apremilast 30 mg OR OSI-461 OR Mirodenafil OR Mirodenafil 100mg OR Mirodenafil 50mg tablet OR PF-04447943 OR PF-04447943 25 mg OR Vesnarinone OR GSK256066 OR gsk 655066 OR MK-0873 OR MK-0873 Patch OR MK-0873 Cream OR MK-0873 2.5 mg OR MK-0873 1.25 mg OR E6005 OR E6005 0.2% OR E6005 0.05% OR Caffeine OR theophylline OR Theophylline ER OR Theophylline 300 mg OR theophylline SR OR Theophylline 300mg OR Pentoxifylline OR Pentoxifylline 400 MG OR Pentoxifylline OR PTX OR Pentoxyfylline Oral Tablets OR Levosimendan OR Levosimendan 2.5 mg/ml Injectable Solution OR levosimendan at a dose of 6 mcg/kg OR Levosimendan infusion OR Levosimendan 2.5 MG/ML OR Dipyidamole OR Dipyridamole 75 MG OR Dipyridamole 200 mg OR Dipyridamole Tablets OR Dipyridamole 25Mg Tab OR Papaverine OR Papaverine Hydrochloride OR Aminophylline OR Aminophylline group OR aminophylline bolus OR Aminophylline 400 mg OR aminophylline hydrate OR cilomilast OR Anagrelide OR anagrelide hydrochloride OR Anagrelide retard OR Anagrelide Hydrochloride Capsules 1 mg OR Anagrelide CR OR Crisaborole OR Crisaborole ointment 2% OR Crisaborole Ointment OR Crisaborole 2% Top Oint OR Drotaverine hydrochloride OR zatolmilast OR Zatolmilast/ BPN14770 OR Ensifentrine OR Ensifentrine 3mg OR Ensifentrine Dose 1 OR Ensifentrine OR RPL554 suspension</b>.