Additional file 1 of Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank
Creators: name: Harris, Katie
name: Peters, Sanne A. E.
name: Woodward, Mark
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Baseline table by menopause status (women). Table S2. Age and number of incident MI events by sex specific quarters of sex hormone level. Table S3. Age-adjusted mean risk factor levels with 95% confidence interval according to O/T ratio and sex. Table S4. Association of sex hormones with MI by sex. Table S5. Association of combinations of sex hormones with MI by sex. Table S6. Association of sex hormones with MI by menopause status (for women). Table S7. Association of sex hormones with MI by menopause status and HRT use (for women). Figure S1. Percentage of Oestrogen and Testosterone detectable status by age group and sex. Pink bars represent women and blue represent men. Figure S2. Percentage of Oestrogen and Testosterone detectable status for women by age group and menopause status. Green bars represent premenopausal women and purple for post-menopausal women. Figure S3. Rates of myocardial infarction and levels of sex hormones, with 95% confidence intervals, by menopause status (for women) and age group. Footnote: Dark green lines represent sex hormone levels for pre-menopausal women and purple (dotted) for post-menopausal women. Black solid lines represent % MI by age group for pre-menopausal women and black dotted lines for post-menopausal women. Where lower confidence intervals were negative for the % MI these have not been plotted. O/T = Oestradiol/Testosterone, Free androgen index (FAI), sex hormone–binding globulin (SHBG). Figure S4. Plots of Oestradiol/Testosterone ratio (nmol/L) in women and men. Lower values of the O/T ratio were observed if oestrogen values were lower than testosterone values, and higher values if oestrogen was higher than testosterone. Of the 52,529 women with detectable levels of the O/T ratio, there were 5522 that had oestrogen concentration greater than testosterone concentration. In men the O/T ratio was generally low, since men tend to have a much higher testosterone level than oestrogen level. Of the 17,580 men with detectable levels of the O/T ratio, six had greater oestrogen concentration than their testosterone concentration. Figure S5. Rates of myocardial infarction and levels of SHBG, and free androgen index (FAI), with 95% confidence intervals, by sex and age group. Sex hormone–binding globulin (SHBG), Free androgen index (FAI) = Total Testosterone/SHBG x 100. Figure S6. Association of quarters of sex hormones with MI by sex. Multiple adjusted hazard ratios (HR) with 95% confidence intervals: Blue Men, Pink/red Women. Multiple adjusted models adjusted for age, smoking status, total cholesterol, BMI, Systolic blood pressure, Townsend deprivation score, diabetes, any anti-hypertensive or lipid lowering medication. O/T, Oestradiol/Testosterone; FAI, Free androgen index; SHBG, sex hormone–binding globulin. Figure S7. Association of quarters of sex hormones with MI by menopause status (for women). Multiple adjusted hazard ratios (HR) with 95% confidence intervals: Dark green pre menopause, purple post-menopause. Multiple adjusted models adjusted for age, smoking status, total cholesterol, BMI, Systolic blood pressure, Townsend deprivation score, diabetes, any anti-hypertensive or lipid lowering medication. O/T, Oestradiol/Testosterone; FAI, Free androgen index; SHBG, sex hormone–binding globulin.