cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A self-reconfigurable platform for built-in-self-test applications
Creators: name: Khalaf, Arkan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: This thesis introduces a novel architecture of a run-time reconfigurable microsystem on chip (SoC). This system consists of a logic block that can be reconfigured at run time, and an embedded multi-microprocessor system that connects to this logic block and can reconfigure it at run time using special resources of Field Programmable Gate Arrays (FPGA). A design flow for run-time reconfigurable logic circuits has been developed and is presented in the context of the implementation of the SoC on a FPGA. This reconfigurable architecture is validated by an application that implements the novel idea of verifying algorithms for testing digital circuits by using run-time reconfigurable techniques, in order to minimize circuit area, as well as test generation and application time. The idea revolves around the dynamic partial reconfiguration of circuits under test, in order to inject stuck-at faults at different locations of the circuit, to verify for and uncover logic structural faults. The thesis presents the design and implementation of a self-reconfigurable platform, where faults are injected at run-time to the circuit under test. It analyzes the ways of injecting faults and the run-time reconfiguration overhead associated with it, while the rest of the circuit is present on the reconfigurable architecture, in order to validate run-time reconfigurable built-in-self-test techniques, as compared to the more traditional methods.
Traditional Aboriginal healing practices: An ethnographic approach
Creators: name: Hunter, Linda M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Anthropology, Cultural.
subject: Health Sciences, Nursing.

description: This thesis explores traditional Aboriginal healing practices as they relate to health issues by asking the research question "How do urban-based First Nations peoples use healing traditions to address their health issues?" The purpose of this thesis was to explore the healing traditions of urban-based First Nations peoples. The objectives were to describe the use of Aboriginal healing traditions, discuss how these traditions addressed health issues, and explore the link between such traditions and holism in nursing practice. Critical ethnography was the qualitative research method used for this thesis. Data collection consisted of eight individual interviews, participant observations over a period of four months, and field notes. The three major categories that emerged from the data analysis were (a) the following of a cultural path, (b) the gaining of balance, and (c) the circle of life. The theme of healing holistically emerged. Healing holistically includes following a cultural path by regaining culture through the use of healing traditions; gaining balance in the four realms of the spiritual, emotional, mental, and physical self, and sharing culture between Aboriginal peoples and non-Aboriginal health professionals, as part of the circle of life. Implications for practice include incorporating the concepts of balance, a holistic outlook, and healing and culture into the health care of diverse First Nations groups. Healing holistically is an ongoing process that continues throughout the lifespan. This process can contribute to empowerment for Aboriginal peoples through an enhanced state of health reached by using traditional healing and understood through a critical ethnography approach.
Hemoglobin binding and catalytic heme extraction by IsdB NEAT domains
Creators: name: Bowden, Catherine F. M.
name: Verstraete, Meghan M.
name: Eltis, Lindsay
name: Murphy, Michael E. P.
Publisher: name: Biochemistry
Year: 2021

description: The Isd (Iron-regulated surface determinant) system is a multi-protein transporter that enables bacterium Staphylococcus aureus to take up iron from hemoglobin (Hb) during human infection. In this system, IsdB is a cell wall-anchored surface protein that contains 2 NEAT domains, one of which binds heme. IsdB rapidly extracts heme from Hb and transfers it to IsdA for relay into the bacterial cell. Using a series of recombinant IsdB constructs which included at least one NEAT domain, we demonstrated that both domains are required to bind Hb with high affinity (KD = 0.42 ± 0.05 µM) and to extract heme from Hb. Moreover, IsdB only extracted heme from oxidized metHb although it also bound oxyHb and the Hb-CO complex. In a reconstituted model of the biological heme relay pathway, IsdB catalyzed heme transfer from metHb to IsdA with a Km for metHb of 0.75 ± 0.07 µN and a kcat of 0.22 ± 0.01 s-¹. The latter is consistent with the transfer of heme from metHb to IsdB as being the rate-limiting step. With both NEAT domains and the linker region present in a single contiguous polypeptide, high affinity Hb binding was achieved, rapid heme uptake was observed, and multiple turnovers of heme extraction from metHb and transfer to IsdA were carried out, representing all known Hb-heme uptake functions of the full-length IsdB protein.
"Travestis politiques": The gay value of Michel Tremblay's dramatic work in translation
Creators: name: Kayahara, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Speech Communication.
subject: Language, General.

description: Michel Tremblay often denies that he writes about gayness, despite frequent themes of sexual difference in his plays. In Hosanna , for example, he has suggested that the gay content is a metaphor for Quebec's aspirations to independence. In other plays, such as Les anciennes odeurs and Messe solennelle pour une pleine lune d'ete, he seems to be advancing a "banalizing" conception of gay identity. Despite these interpretations, a number of Anglophone academics have mobilized Tremblay's texts to make arguments about community-based gay identity and have treated Tremblay as a gay writer. This thesis seeks to determine if this appropriation is facilitated by the translation process, as a result of the translators intervening in the texts to enhance their gay content. Ultimately, it seems this is not the case, suggesting that the appropriation of Tremblay's work results more from the gay community reading its own conceptions of gay identity into the texts than from the translation process.
VSV infection of resting and activated T lymphocytes
Creators: name: Taylor, Rebecca Ann C
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Cell.
subject: Chemistry, Biochemistry.

description: Resting T lymphocytes are uniquely resistant to VSV even at high multiplicities of infection but they can be rendered fully permissive for VSV replication following in-vitro activation with monoclonal anti-CD3 and PMA with ionomycin. The block to VSV replication is at the level of viral RNA production and is independent of transcription following infection. T lymphocytes must be activated before infection for at least 24 hours to be rendered susceptible to VSV and transcription is an absolute requirement during this process. Fusion of resting and activated T cells results in a resistant cell indicating that the resistant state is dominant. Resting T cells do not produce interferon (IFN) alpha or beta in response to VSV infection whereas activated T cells produce both but have a down modulated response to the antiviral activity of type I IFNs. Gene expression array analysis demonstrates that the interferon response factors, IRF-4 and IRF-8, are up regulated during activation and a number of interferon stimulating genes (ISG), including ISG20, MxA and GBP-1 are down regulated during activation. IRF-4 and IRF-8 have both been described to bind to and inhibit transactivation from the interferon stimulated response elements (ISRE) in the promoters of a number of ISGs and this could explain the down modulated antiviral response to type I IFNs in activated T cells. The IFN-independent constitutive expression of these ISGs in resting T cells is a possible mechanism for their unique resistance to VSV replication.
Abating Ammonia Emissions: Farmers’ Willingness to Use Slurry Acidification Techniques during Spreading
Creators: name: Thiermann, Insa
name: Latacz-Lohmann, U.
name: Thiermann, Insa
name: Latacz-Lohmann, U.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agricultural and Food Policy
subject: Environmental Economics and Policy
subject: Farm Management
subject: Slurry Acidification
subject: Emission Abatement
subject: Ammonia Emissions
subject: Discrete Choice

description: This article seeks to determine farmers’ willingness to apply slurry acidification during spreading. Slurry acidification is a novel technique to reduce ammonia emissions, which has been pioneered in Denmark. In an online discrete choice survey of German livestock farmers, the respondents were asked to choose between different policy schemes to promote the use of acidification techniques and the status quo. The support schemes were characterised by the following attributes: cost share, expected emission reduction as well as reliefs from, and tightenings of, the German Fertilizer Ordinance. In addition, the character-istics of farmers and farms were elicited. The data were estimated using a mixed logit model. The esti-mated probability of farmers to choose a support scheme is 89 %. All policy variables are significant for acceptance and show the expected signs. Emission reduction is important to farmers and increases the chances of participation in a support scheme significantly. Furthermore, the cost share offered and the exemption from the requirement to incorporate slurry immediately after spreading have a significantly positive impact on farmers’ willingness to participate. By contrast, the higher the nitrogen load factor by which the extra nitrogen in the slurry must be counted in a farmer’s fertilizer planning (a provision of the German Fertilizer Ordinance), the lower the probability of participation. Concerning farm and farmer characteristics, farmers with grazing livestock show lower acceptance as do sow holders. Older farmers and better educated farmers are more likely to participate.
A distributed network management systems for user-controlled lightpath provisioning and its security requirements
Creators: name: Chen, Jun
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.

description: There is a growing trend for many large enterprises and other users to acquire their own optical networks. These customer-owned and managed networks bring cost saving benefits as well as management challenges, especially in the security aspect. In this thesis, a distributed network management system based on Service Oriented Architectures for customer-owned optical networks is presented. The system realizes User-Controlled Lightpath Provisioning and provides users the ability to make end-to-end connections across multiple administrative domains. However, the current version of the system does not meet the security requirements of UCLP. This thesis also presents the research work on how to overcome the security challenge in customer-owned optical network management. The security requirements of the system are analyzed and the major difficulties are identified. Different access control models and security technologies are investigated. An access control mechanism based on Attribute Certificate is chosen for the future implementation of the UCLP system.
The impact of forest fire on permafrost slopes Klondike area, Yukon Territory
Creators: name: Coates, James
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Ecology.
subject: Physical Geography.
subject: Agriculture, Forestry and Wildlife.

description: Numerous forest fires occurred during the summer of 2004 in the Klondike Goldfields region of the Yukon Territory, an area of extensive discontinuous permafrost. More than 35 shallow detachment failure landslides developed in subsequent weeks in Steele Creek, a small drainage basin located about 60 km south of Dawson City. Preliminary observations of the failures and near-surface thermal regime were made through freeze-up of 2004 and continued in the summers of 2005 and 2006. Detachment failures were mapped and individual sites were surveyed. Air and ground temperatures were measured in burned and unburned areas. In addition, two-dimensional DC resistivity transects were used to examine subsurface conditions in the area. Forest fire contributed to detachment failure activity on permafrost slopes by destroying the surface organic mat, causing burned surface temperatures to rise, thawing active layers by up to 20 cm (+31%) deeper than unburned slopes and weakening the surface root structures. Deeper thaw melted transient layer ground ice, raising soil porewater pressures. The thermal differences between burned and unburned sites were greater at the north-facing than south-facing sites, and active layer freezing and thawing processes varied according to both aspect and burned status. More southerly-facing and/or burned sites generally thawed earlier, refroze later and had warmer temperatures than more northerly and/or unburned sites. Thaw of burned areas with high ground surface temperatures can be expected to continue, depending on climatic conditions, until sufficient revegetation occurs to shade the surface and rebuild the insulating organic mat. The detachment failures occurred from a few weeks to two years after forest fire, and only on slopes where permafrost was extensive. They were not similar to others in the literature in that almost all occurred in coarse-gained soils and had failure planes elevated above the permafrost table. These landslides were flow-type failures that rafted portions of the organic mat on top of deforming, non-cohesive sediment. They occurred in areas of deeper thaw but their distribution and the resistivity data suggest that they were associated with supra-permafrost taliks which concentrated groundwater flow. In an unglaciated area like the Klondike region this landsliding process has likely occurred thousands of times during the Pleistocene and may be responsible for elements of the form of the region's slopes. Predicted increases in the frequency and magnitude of forest fire in the boreal forest due to warming climates may increase incidence of these types of failures.
Some properties of a composite solid propellant.
Creators: name: Campbell, Gordon A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1968
Subjects: subject: Engineering, Chemical.

description: Temperature profiles during polymerization, for the infinite solid cylinder, the infinite hollow cylinder and the star perforated infinite cylinder of polyurethane ammonium perchlorate solid propellent, have been determined. They show that the temperature across the solid rises considerably above the wall temperature and exceeds the 60°C (140°F) limit, recommended for the polyurethane propellants, by a considerable margin, often as much as 25°F. An end effect test indicated that a hot region of fleeting duration is present near the ends of the solid. Burning rates, measured radially across a piece of solid propellant, showed that a variation of burning rate with radius is present. The burning rates across a thin walled hollow cylinder of propellant did not vary radially. Correlation coefficients between the burning rate and the maximum temperature gradient for the solid cylinder ere of the order of 0.92, indicating that a high degree of correlation is present between burning rate and polymerization temperature, Correlation coefficients of this magnitude also show that one of the real causes of uneven burning in rocket motors is high temperature during polymerization.
Part I. The formation of benzyne in a fragmentation reaction. Part II. A study of restricted rotation about the nitrogen-cobalt bond by NMR.
Creators: name: Osyany, Judith Margaret.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1963
Subjects: subject: Chemistry, Analytical.

description: The deamination reaction of 2-aminotriphenylcarbinol in 97% formic acid has been studied in order to investigate the possibility of benzyne formation via a carbonium ion precursor. Product analysis showed that a small but significant amount of benzophenone was formed, which indicated some fragmentation. While this evidence strongly suggests that the other fragment was benzyne, no direct proof of this has been obtained.
Exploring the performance and self-regulation of medical students through an intervention aimed at regulating the way they feel
Creators: name: Simon, Christopher R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Education, Educational Psychology.

description: Research has shown that how individuals feel affects their performance (Doell et al., 2006; Durand-Bush et al., 2005). Since felt experiences in the context of medicine have been shown to be of importance (Novack et al., 1997; Sotile & Sotile, 2002), and self-regulation skills have been found to help foster learning (Zimmerman, 1990), the purpose of this study was to examine the self-regulation of the felt experiences of four medical students through an intervention guided by the Resonance Performance Model (RPM) (Newburg et al., 2002), and determine how it affected self-defined standards of performance. Results of this multiple case study (Stake, 2006) showed that each student was able to identify and experience, the way they wanted to feel within their performance environment, and reach an optimal level of performance during the intervention process by attuning to and regulating the way they felt. Implications for future research on performance as a self-defined process, and the provision of opportunities for self-regulated learning in medical education are discussed.
The theory of neo-enosis: The Republic of Cyprus's EU membership as an objective of Pan-Hellenic nationalism A history
Creators: name: Watson, James
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: History, European.

description: The Greek Cypriot struggle for enosis, or union with Greece, dominated Cypriot politics until the military coup and Turkish invasion of 1974. But the roots of the enosis movement maintained their Pan-Hellenic character, later resurfacing with the declaration of the Turkish Republic of Northern Cyprus in 1983 and surviving in the traditional institutions of the Greek Cypriot state. The Orthodox Church, the National Guard, and 'Hellenic-centred' education all identified with the Greek Cypriot struggle for union with Greece. The concept of neo-enosis, or new union, is presented as the political objective of the Cypriot Republic from the late 1980s. Its dual objectives were to bring Cyprus politically closer to Greece through the island's application to the European Union and to pressure Turkey into accepting a Cyprus settlement. The Republic of Cyprus's application to the European Union, as argued by the theory of neo-enosis, was therefore a political manifestation of the resurgent Greek nationalism on Cyprus post-1974. The process of European Union accession strengthened the Hellenic bonds between Cyprus and Greece. Cypriot accession was only assured by a Greek threat to prevent any European enlargement unless Cyprus was accepted in the first wave of expansion to Eastern Europe. This joint effort required the common exertion of both states politically, economically, and militarily. Greek and Cypriot membership in the EU consolidates and strengthens these links. The European Union was therefore used as a vehicle for a Pan-Hellenic nationalist agenda. The accession of the Republic of Cyprus to the European Union also linked potential Turkish EU membership to a Cyprus settlement. The Greek Cypriots could threaten a veto of Turkish EU entry as long as the island remained divided. This second function of the theory of neo-enosis produced the 'Annan Plan', rejected by the Greek Cypriots because of its perceived unfavourable conditions. Joint European Union membership provides the Republic of Cyprus and Greece with a forum in which to formalize national policies and devise a final settlement that maintains the territorial integrity of the entire island.
Acidic Microenvironments in Waste Rock Characterized by Neutral Drainage: Bacteria–Mineral Interactions at Sulfide Surfaces
Creators: name: Dockrey, John W.
name: Lindsay, Matthew B. J.
name: Mayer, K. Ulrich
name: Beckie, Roger D.
name: Norlund, Kelsey L. I.
name: Warren, Lesley A.
name: Southam, Gordon
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Microbial populations and microbe-mineral interactions were examined in waste rock characterized by neutral rock drainage (NRD). Samples of three primary sulfide-bearing waste rock types (i.e., marble-hornfels, intrusive, exoskarn) were collected from field-scale experiments at the Antamina Cu–Zn–Mo mine, Peru. Microbial communities within all samples were dominated by neutrophilic thiosulfate oxidizing bacteria. However, acidophilic iron and sulfur oxidizers were present within intrusive waste rock characterized by bulk circumneutral pH drainage. The extensive development of microbially colonized porous Fe(III) (oxy)hydroxide and Fe(III) (oxy)hydroxysulfate precipitates was observed at sulfide-mineral surfaces during examination by field emission-scanning electron microscopy-energy dispersive X-ray spectroscopy (FE-SEM-EDS). Linear combination fitting of bulk extended X-ray absorption fine structure (EXAFS) spectra for these precipitates indicated they were composed of schwertmannite [Fe₈O₈(OH)₆₋₄.₅(SO₄)₁₋₇₅], lepidocrocite [γ-FeO(OH)] and K-jarosite [KFe₃(OH)₆(SO₄)₂]. The presence of schwertmannite and K-jarosite is indicative of the development of localized acidic microenvironments at sulfide-mineral surfaces. Extensive bacterial colonization of this porous layer and pitting of underlying sulfide-mineral surfaces suggests that acidic microenvironments can play an important role in sulfide-mineral oxidation under bulk circumneutral pH conditions. These findings have important implications for water quality management in NRD settings.
Discerning devotional readers: Readers, writers, and the pursuit of God in some late medieval texts
Creators: name: Lewis, Anna
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Literature, Medieval.
subject: Religion, History of.
subject: Literature, English.

description: This dissertation is concerned with both the way vernacular religious texts were written, and the way they were read, in late medieval England. The context for this discussion is the growth in lay readership and the increasingly ambitious spiritual aspirations of sections of the laity. This dissertation argues that awareness of this wider audience profoundly shaped the way writers presented their texts. Regardless of theological perspective or general intent, medieval writers reveal a common tendency to try and identify "right" readers for their texts, invoking specific interpretive communities, and guiding reader response by establishing parameters for interpretation. The first half of the study draws attention to this engagement with hermeneutics as it is found in Lollard tracts, The Cloud of Unknowing, Nicholas Love's Treatise on the Sacrament, Julian of Norwich's Revelation of Love, and the anonymous works, Book to a Mother and The Recluse. Shifting attention on to the reader in its second half, the dissertation uses the evidence of two early fifteenth-century collections of religious texts to demonstrate how lay readers could and did fit their reading material around their own concerns and interests, and that these interests could be extremely diverse. Following Nichols and Wenzel's approach of studying the "whole book," I argue that by choosing to read certain texts together, readers were able to fundamentally alter the interpretation of those texts. Taken as a whole, this study demonstrates connections between contemporaneous works which have rarely been dealt with together because of the tendency to divide medieval religious literature into discrete generic categories ("devotional," "mystic," "pastoral") or discrete doctrinal categories ("Lollard," "orthodox"). Its discussion of religious texts and manuscripts exposes the inadequacy of such categories given the depth, complexity, and range of religious opinion in late medieval England.
Jouets antiques, jouets de toujours ?
Creators: name: Manson Michel
Publisher: name: Zenodo
Year: 2019
Subjects: Jouets, Antiquité, Époque Moderne

description: Jouets antiques, jouets de toujours ? in V. Dasen (dir.) Ludique ! Jouer dans l'Antiquité. Catalogue de l'exposition, Lyon Lugdunum, Musée et théâtres romains, 20 juin - 1 décembre 2019, Gent, 2019, p. 114
Regulation of IL-12p40 expression by HIV-Nef in human monocytic cells
Creators: name: Ma, Wei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Biology, Molecular.
subject: Health Sciences, Immunology.

description: Impaired cellular immunity because of dysregulation of Th1 cytokines is a major feature of AIDS. Interleukin-12 (IL-12) is an important Th1 cytokine, which plays a critical role in cellular immunity by producing IFNgamma from T and NK cells. Biologically active IL-12 is a 70 kD glycoprotein composed of two disulfide-linked subunits, p35 and p40. The p40 subunit is an appropriate indicator for IL-12 due to its expression in IL-12p70 producing cells including monocytes/macrophages in response to various stimuli, such as bacterial endotoxin, LPS. However, how LPS induces IL-12p40 in monocytes is not clear. A severely decreased IL-12p40 production has been found in PBMCs and macrophages from HIV positive individuals and is believed to be correlated to HIV-associated immunodeficiency. The mechanism underlying the impaired IL-12 production in HIV infected monocytes/macrophages remains unknown. HIV-1 Nef protein, an AIDS pathogenetic factor, has been shown to downregulate Th1 cytokines. In this study, I investigated the potential signaling pathways involved in the downregulation of IL-12p40 production by intracellular Nef in LPS-activated human monocytic cells. LPS activates monocytes by coupling to CD14/TLR4 receptor on the cell surface and activating MAPK pathways, calcium/PI3K pathways and several transcription factors including Ets2, NFkappaB, and AP-1. These signaling components have been shown to be implicated in downregulation of IL-12p40 production by several immunosuppressive drugs such as dexamethasone (Dxm), FK506 and cyclosporine A (CyA). By utilizing these immunosuppressive drugs and the specific inhibitors that are involved in MAPKs and calcium/PI3K signaling pathways. I demonstrated that Dxm and FK506/CyA mediated downregulation of IL-12p40 production is regulated by two distinct and independent signaling pathways, JNK and CaMKII activated PI3K pathways in LPS-stimulated human monocytic cells, in which, Dxm regulating via the JNK whereas FK506/CyA regulating via the CaMKII. By extensive mutative analyses of the IL-12p40 promoter, I further demonstrated that the cis-binding motifs of transcription factor AP-1 and NFkappaB were required for IL-12p40 transcription in both signaling pathways. I then focused on intracellular Nef as a potential repressive molecule in regulation of MAPKs, CaMKII activated PI3K and transcriptional factors involved in LPS-induced IL-12p40 expression. I demonstrated that intracellular Nef downregulates IL-12p40 in human monocytes by specifically inhibition the INK MAPK and transcription factor NFkappaB. These studies may provide new therapeutic tools for the treatment of inflammation and autoimmune diseases and a further understanding for significant functions of intracellular Nef in AIDS pathogenesis.
The effect of glucose regulation on cognitive functioning in a healthy sample of older adults
Creators: name: Tsiakas, Maria
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Gerontology.
subject: Psychology, Clinical.
subject: Psychology, Cognitive.
subject: Psychology, Physiological.

description: Type II diabetes and impaired glucose tolerance (IGT) are both associated with cognitive impairment and an increased risk of dementia, and normal aging has been shown to be accompanied by abnormalities in glucose regulation. The present study was conducted to determine if variations in cognitive performance would be observed as a function of glucose regulation in a healthy elderly population. Thus, cognitive functioning was measured in 93 healthy male and female older participants who ranged in age from 55 to 88. Participants had a glucose tolerance tests from which several biological indices were obtained including various glucose and insulin measures, and were separated into better and poorer glucoregulatory groups on the basis of these indices. Participants underwent two cognitive testing sessions, one after drinking a saccharin solution and another after drinking a glucose solution (50g). Participants with worse glucose regulation performed worse on measures of working memory, executive function, and processing speed compared to participants with better glucose regulation. Additionally, older participants with worse glucose regulation obtained the lowest scores on the majority of cognitive measures compared with younger participants and those with better regulation. A significant enhancement of cognitive performance by glucose was not clearly observed. The results suggest that cognitive functioning may be compromised before glucoregulatory impairment reaches levels consistent with IGT or Type II diabetes.
Chinese relativization: Ordering at the syntax-phonology interface
Creators: name: Chen, Chiu-Hung
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Language, Linguistics.

description: The main concern of this dissertation is Chinese word order, with a special focus on Chinese relative clauses. Chinese is generally considered a head-initial language. Nevertheless, judging from the surface word order, relative clauses appear to be head-final. This fact seems to violate the Head-Direction Parameter according to which all phrase categories in one language are either head-initial or head-final. I propose a theory from a syntax-phonology interface perspective, arguing that (i) relative clauses in Chinese receive a head-initial modifier phrase analysis, following Rubin (in prep.); (ii) de is a clitic-like element that lowers to the first relevant XP it finds, a special movement operation at the syntax-phonology interface. The main argument is built upon the evidence that de behaves like a clitic. I argue that there are in fact two types of clitics in Chinese, one being toneless and another being tone-bearing. The former lacking tone and stress appears in the enclitic position, while the latter always appears in the proclitic position. The differential behavior of these two types of clitics is triggered by the absence of a foot in toneless clitics. It is this absence which forces lowering of de. The generalization based on the behavior of these two types of clitics is accounted for in an Optimality framework. I also show that the position of other functional categories such as aspectual markers and sentence-final particles in Chinese is influenced by their prosodic status.
Desertion, identity and the experience of authority in the North American Squadron of the Royal Navy, 1745-1812
Creators: name: Hubley, Martin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: History, Canadian.

description: No detailed study of the causes of desertion, the scale of the problem, or its effects on naval operations and interplay with society and identity formation in both the imperial peripheries of North America and in the British Isles, has previously been undertaken. Using underutilised sources such as ship muster and pay books, this dissertation utilises the phenomenon of naval desertion in North America as a lens to reconstruct the experiences of the common Royal Navy seaman from the establishment of the North American station, through the Age of the American Revolution, until the War of 1812. The study posits that the perception and practice of discipline in the naval service began to change dramatically as early as 1775, if not before, and that the primary impetus behind such calls for change was the problem of desertion and its attendant consequences. The unrest created by the republican ideals of the American Revolution and emerging concepts of American identity, often incompatible with super-imposed "Britishness" and multiple identities, led to new proposals for ubiquitous, centrally controlled and monitored systems of discipline across the fleet. The experience of authority of the average sailor aboard ship was similar to what he would have experienced on shore in the face-to-face parishes of Hanoverian England. Ships, and sometimes naval stations, perceived themselves as floating communities that possessed values and networks of kinship, profession, and status as their counterparts ashore. The dissertation reinforces the concept that the eighteenth-century naval justice system was more formal than has often been perceived. It had many commonalities with the common law system ashore, and was riddled at all levels with discretionary authority, which at times could become arbitrary in nature. Individuals held multiple roles in overlapping "grids of power", which were based upon hierarchical power structures of status, rank, ethnicity, race, religion and language. The key characteristic of a Royal Navy seaman in this era was his cultural mobility, based upon multiple, concentric and shifting identities and loyalties, and strong connections to larger Atlantic, and imperial, maritime communities. Finally, the thesis seeks to personalise the experiences of average seamen and marines on the vessels of the North American squadron, whose lives remain largely effaced from history.
The Quebec secession reference: The constitutionalization of Quebec secession
Creators: name: Morrison, Alec
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: History, Canadian.

description: The purpose of this thesis is to explain why the government of Canada decided to refer three questions related to whether or not the government of Quebec could unilaterally effect the secession of Quebec from Canada, to the Supreme Court for a judicial opinion in 1996. To do so, this thesis will address two important questions related to the objectives that the government of Canada had in initiating the Quebec Secession Reference. First, why did the government of Canada wait until 1996 to clarify how a province could be removed from the federation when there was a significant secessionist movement in Quebec in 1968, a secessionist government of Quebec in 1976, a referendum on the secession of Quebec from Canada in 1980, and another in 1995? Second, when the government of Canada did decide to establish a position on how Quebec could leave the federation, why did it use the Supreme Court of Canada to do so? (Abstract shortened by UMI.)
A Studies towards the formation of asymmetric quaternary centres via radical allylation B Applications of chiral hydrazide organocatalysts to Diels-Alder, hydride reduction, and alpha-chlorination reactions C Studies directed towards the synthesis of potential HIV-1 reverse transcriptase inhibitors: 9-Alkylaryl TIBO derivatives
Creators: name: Aumand, Livia M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Chemistry, Organic.
subject: Chemistry, Pharmaceutical.

description: In part A, the attempts at synthesizing quaternary centres via radical reactions are described. Using tartrate acetals as chiral auxiliaries, tertiary bromides were submitted to radical allylation conditions in an effort to form 1,3-dicarbonyl compounds 27 possessing an asymmetric quaternary centre at C2.* Part B describes the synthesis of chiral hydrazide 129 and its ability to catalyze the Diels-Alder reaction is examined. The application of chiral hydrazides 131 to the organocatalytic hydride reduction of alpha,beta-unsaturated aldehydes and the alpha-chlorination of aldehydes is also recounted herein.* Finally, in Part C, efforts towards the synthesis of potential broad spectrum HIV-1 reverse transcriptase inhibitors are described. Compounds 161 are based on the TIBO family of compounds and possess a novel alkylaryl appendage.* *Please refer to dissertation for diagrams.
Factors related to childbirth nurses' intentions to provide continuous labour support to women during childbirth
Creators: name: Payant, Laura
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Health Sciences, Nursing.

description: Purpose. Explore the organizational barriers and examine determinants of nurses' intentions to practice continuous labour support (CLS). Design. Exploratory two-phase study using qualitative and quantitative methods. Participants. Childbirth nurses, educators and managers from two birthing units on two campuses of one hospital, in an urban city in Ontario, Canada. Phase I, N=10/10; Phase II, N = 97/129. Methods. Semi-structured interviews with content analysis followed by a survey using the Theory of Planned Behavior with descriptive, univariate and multiple regression analyses. Results. Unit acuity, method of patient assignment, need to cover other nurses for break and nurse-patient ratio, were the most frequently reported barriers. Nurses' attitude scores, subjective norm scores and intention scores toward providing CLS to women with epidural analgesia were lower than those for a non-epidural case study. Conclusions. Organizational barriers impact nurses' ability to provide CLS. Nurses have lower intentions to provide CLS to women with epidural analgesia.
The Effect of Lateral Eccentricity on Failure Loads, Kinematics, and Canal Occlusions of the Cervical Spine in Axial Loading
Creators: name: Van Toen, C.
name: Street, John T.
name: Oxland, Thomas R.
name: Cripton, Peter Alec, 1965-
Publisher: name: International Society of Biomechanics
Year: 2021

description: Current neck injury criteria do not include limits for lateral bending combined with axial compression and this has been observed as a clinically relevant mechanism, particularly for rollover motor vehicle crashes. The primary objectives of this study were to evaluate the effects of lateral eccentricity (the perpendicular distance from the axial force to the centre of the spine) on peak loads, kinematics, and spinal canal occlusions of subaxial cervical spine specimens tested in dynamic axial compression (0.5 m/s). Twelve 3-vertebra human cadaver cervical spine specimens were tested in two groups: low and high eccentricity with initial eccentricities of 1% and 150% of the lateral diameter of the vertebral body. Six-axis loads inferior to the specimen, kinematics of the superior-most vertebra, and spinal canal occlusions were measured. High speed video was collected and acoustic emission (AE) sensors were used to define the time of injury. The effects of eccentricity on peak loads, kinematics, and canal occlusions were evaluated using unpaired Student t-tests. The high eccentricity group had lower peak axial forces (1544 ±629 vs. 4296 ±1693 N), inferior displacements (0.2 ±1.0 vs. 6.6 ±2.0 mm), and canal occlusions (27 ±5 vs. 53 ±15%) and higher peak ipsilateral bending moments (53 ±17 vs. 3 ±18 Nm), ipsilateral bending rotations (22 ±3 vs. 1 ±2o), and ipsilateral displacements (4.5 ±1.4 vs. -1.0 ±1.3 mm, p<0.05 for all comparisons). These results provide new insights to develop prevention, recognition, and treatment strategies for compressive cervical spine injuries with lateral eccentricities.
Amino-terminal transactivation subdomains of p53 contribute equally to p53-induced gene expression
Creators: name: Smith, Jennifer M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.

description: The p53 tumour suppressor is mutated in over 50% of sporadic cancers. Its tumour suppressive functions arise in large part from transcriptional activation of target genes. Two adjacent regions within the transactivation domain of p53 are sufficient to support sequence-specific transactivation when fused to a heterologous DNA binding domain. It has been hypothesized that these two subdomains of p53 may contribute to the expression of distinct p53-responsive genes and regulate distinct biological pathways. In order to examine the subdomain requirements during transactivation, we used oligonucleotide microarrays to identify transcripts induced by variants of p53 with point mutations within subdomains 1, 2, or both (QS1, QS2, and QS1/QS2, respectively). Expression of wild type p53 (P53WT) statistically induced 254 transcripts and apoptosis transcripts (GO#0006915) were the only statistically over represented group. Most of these transcripts were poorly induced by the p53 variants and there was a corresponding decrease in the ability of these variants to induce apoptosis. Strikingly, several well known p53-regulated transcripts including TNFRSF10B, BTG2, and POLH were increased to wild type levels by p53QS1 and p53QS2 but not p53QS1/QS2, indicating that either subdomain1 or 2 is sufficient for p53-dependent expression of a small subset of p53-responsive genes. Unexpectedly, there was no evidence for p53QS1- or p53 QS2-specific gene expression. Taken together, these results demonstrated heterogeneity in the requirement for transactivation subdomains 1 and 2 of p53 without subdomain-specific contributions to p53-induced gene expression. The MafB transcript was identified as a p53WT -induced transcript that was not statistically increased in response to either p53QS1 or p53QS2 expression. Nonetheless, MafB expression increased more in response to the QS2 compared to the QS1 variant of p53 so MafB was studied further as a potential p53 target gene exhibiting a QS2-specific pattern of expression. Expression of p53WT increased MafB mRNA and protein levels and bound to a putative response element 2400bp upstream of the transcription start site. Expression of p53QS2 consistently increased MafB expression more than p53QS1, however this level did not approach the expression of MafB induced by p53WT. Therefore, MafB represents a novel p53-regulated transcript that is poorly induced by both p53QS1 and p53QS2.
Characterization, modeling and design of the braided pneumatic muscle
Creators: name: Doumit, Marc D
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, Mechanical.

description: Electrical motors, hydraulic and pneumatic cylinders are traditionally used as actuators. They are very effective for most industrial applications; however, they are not suitable for devices that interact with human beings. Such devices can be medical assisting robots, robotic prostheses for handicapped people and others. To ensure the safety of the user (i.e. patient) and the effectiveness of the device, these applications require an actuator that is compliant and physically flexible, yet powerful and of light weight. The Braided Pneumatic Muscle, a pneumatic linear actuator, is a candidate device that satisfies the above requirements. Although invented in 1941, limited experimental evaluation of the BPM has hindered its applicability until 1961. Moreover, accurate mechanical models and design processes, as well as the issues of proper control of the device, still limits its wide spread application. This thesis aims to study the Braided Pneumatic Muscle behaviour, develop mechanical models to characterize this as well as to propose a design process that enables the user to select the Braided Pneumatic Muscle size and configuration based on the required muscle force, the muscle contraction distance and the muscle stiffness. In this thesis, a comprehensive experimental evaluation is achieved which led to the discovery of new muscle properties as well as the understanding of muscle behaviour. Moreover, a novel force-based modeling approach has been developed and has resulted in accuracies of the static and dynamic models that are better than those of published analytical models. Furthermore, the muscle's dynamic behaviour has been modeled using linear and non-linear system identification models. Finally, the closed loop behaviour of the Braided Pneumatic Muscle was analyzed with a Proportional Integral Derivative controller.
Process-Based Modeling to Assess the Effects of Recent Climatic Variation on Site Productivity and Forest Function across Western North America
Creators: name: Waring, Richard H.
name: Coops, Nicholas C.
name: Mathys, Amanda
name: Hilker, Thomas
name: Latta, Greg
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: A process-based forest growth model, 3-PG (Physiological Principles Predicting Growth), parameterized with values of soil properties constrained by satellite-derived estimates of maximum leaf area index (LAIᵐᵃˣ), was run for Douglas-fir (Pseudotsuga menziesii) to contrast the extent to which site growth potential might vary across western North America between a cool, wet period (1950–1975) and a more recent, generally warmer and drier one (2000–2009). LAIᵐᵃˣ represents a surrogate for overall site growth potential, as demonstrated from a strong correlation between the two variables, with the latter based on the culmination of mean annual increment estimates made at 3356 ground-based U.S. Forest Service survey plots across the states of Oregon and Washington. Results indicate that since 2000, predicted LAIᵐᵃˣ has decreased more than 20% in portions of the Southwest USA and for much of the forested area in western Alberta. Similar percentage increases in LAIᵐᵃˣ were predicted for parts of British Columbia, Idaho and Montana. The modeling analysis included an assessment of changes in seasonal constraints on gross primary production (GPP). A general reduction in limitations caused by spring frost occurred across the entire study area. This has led to a longer growing season, along with notable increases in summer evaporative demand and soil drought for much of the study area away from the maritime influence of the Pacific Ocean.
Survival analysis of patients seen at the Ottawa Hospital Regional Cancer Centre with early breast cancer, 1985--2001: Effect of changes in stage and adjuvant chemotherapy over time
Creators: name: Nicholas, Garth
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Health Sciences, Epidemiology.
subject: Health Sciences, Health Care Management.
subject: Health Sciences, Oncology.

description: Breast cancer is the commonest cancer affecting Canadian women. Recent decades have seen a trend of decreasing breast cancer mortality. This has been attributed to several causes, including greater use of screening mammography and increased efficacy of adjuvant chemotherapy. We studied the effect of these two factors on the overall survival of breast cancer patients at the Ottawa Hospital Regional Cancer Centre. Data were collected from 2985 charts from the years 1985, 1988, 1992, 1995, 1998, and 2001. Adjuvant chemotherapy was associated with a decreased hazard of death from any cause (HR=0.783 p=0.0208). A decrease in mean tumour size seen over the time period of the study is potentially attributable to mammography screening. Decreased tumour size was associated with a decreased hazard for death (HR 0.986 p<0.0001). No difference in overall survival between earlier and later cohorts could be demonstrated, perhaps due to shorter follow up in later cohorts.