cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Detecting Major Genetic Loci Controlling Phenotypic Variability in Experimental Crosses
Creators: name: Rönnegård, Lars
name: Valdar, William
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Traditional methods for detecting genes that affect complex diseases in humans or animal models, milk production in livestock, or other traits of interest, have asked whether variation in genotype produces a change in that trait’s average value. But focusing on differences in the mean ignores differences in variability about that mean. The robustness, or uniformity, of an individual’s character is not only of great practical importance in medical genetics and food production but is also of scientific and evolutionary interest (e.g., blood pressure in animal models of heart disease, litter size in pigs, flowering time in plants). We describe a method for detecting major genes controlling the phenotypic variance, referring to these as vQTL. Our method uses a double generalized linear model with linear predictors based on probabilities of line origin. We evaluate our method on simulated F2 and collaborative cross data, and on a real F2 intercross, demonstrating its accuracy and robustness to the presence of ordinary mean-controlling QTL. We also illustrate the connection between vQTL and QTL involved in epistasis, explaining how these concepts overlap. Our method can be applied to a wide range of commonly used experimental crosses and may be extended to genetic association more generally.
A Simple Motivated Completion of the Standard Model below the Planck Scale: Axions and Right-Handed Neutrinos
Creators: name: Salvio, Alberto
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study a simple Standard Model (SM) extension, which includes three families of right-handed neutrinos with generic non-trivial flavor structure and an economic implementation of the invisible axion idea. We find that in some regions of the parameter space this model accounts for all experimentally confirmed pieces of evidence for physics beyond the SM: it explains neutrino masses (via the type-I see-saw mechanism), dark matter, baryon asymmetry (through leptogenesis), solve the strong CP problem and has a stable electroweak vacuum. The last property may allow us to identify the Higgs field with the inflaton.
description: 8 pages, 4 figures. Phys. Lett. B version: references and discussion on light right-handed neutrinos added
Επιχώριες προσαρμογές με παραδείγματα το «Ορλάντο» της Βιρτζίνια Γουλφ και το «ο Τσέχωφ και εγώ» του Θεοδόση Πελεγρίνη
Creators: name: Kosmopoulou, Despina
Publisher: name: iNTERCULTURAL tRANSLATION iNTERSEMIOTIC
Year: 2023
Subjects: προσαρμογή; μεταφραστικότητα; διαπολιτισμικότητα; διακειμενικότητα; σημειωτικά συστήματα

description: Μία από τις λειτουργίες του θεάτρου είναι να αντικατοπτρίζει το κοινωνικοπολιτικό, πολιτισμικό και δη το διαπολιτισμικό γίγνεσθαι μιας εποχής, βασιζόμενο στις ιδιότητες της ζωντάνιας που διακατέχει μια θεατρική διασκευή, της πολυσημίας, της πολυγλωσσικότητας και πολυπολιτισμικότητας. Η περίπτωση επιχώριων κειμενικών προσαρμογών στο ελληνικό θέατρο του 21ου αιώνα θα προσεγγιστεί μέσα από την ανάλυση δύο θεατρικών έργων: του «Ορλάντο», σε θεατρική απόδοση κειμένου και σκηνοθεσία του Νίκου Καμτσή, το οποίο προέρχεται από το ομώνυμο μυθιστόρημα της Βιρτζίνια Γουλφ, και του «ο Τσέχωφ αι εγώ» του Θεοδόση Πελεγρίνη, το οποίο αποτελεί ένα συνδυασμό του μονόπρακτου «οι βλαβερές συνέπειες του καπνού» του Άντον Τσέχωφ και του αλληγορικού – φιλοσοφικού θεατρικού έργου του Πελεγρίνη «Η σταφίδα». Τα δύο εξεταζόμενα έργα παρουσιάζουν μία ενδιαφέρουσα ομόλογη δομή στο κομμάτι της αυτοβιογραφίας διαφέρουν όμως στο κομμάτι της προσαρμογής με το «Ορλάντο» να αποτελεί μυθιστόρημα που μετεγγράφηκε σε θεατρικό ενώ το «ο Τσέχωφ και εγώ» προήλθε από τη σύνθεση και διασκευή δύο θεατρικών σε ένα ενιαίο έργο. Οι δύο θεατρικοί συγγραφείς και σκηνοθέτες δημιουργούν ένα νέο κείμενο, ένα υπερκείμενο, με στόχο να αναδείξουν τις προβληματικές των υποκείμενων έργων, αφήνοντας το θεατή να ανακαλύψει τις απαντήσεις και τα νοήματά του. Στην παρούσα μελέτη θα μελετηθεί ο τρόπος και ο βαθμός προσαρμογής και πρόσληψης των δύο έργων ως διακείμενα μέσα από σημειωτικά σχήματα ενώ με αρωγό τη θεωρία των έμφυλων ταυτοτήτων θα εξετασθεί η μετάβαση από την εκκεντρικότητα του Ατόμου στην ολότητα και συλλογικότητα του Ανθρώπου.
description: iNTERCULTURAL tRANSLATION iNTERSEMIOTIC, Vol 12, No 1 (2023)
Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice
Creators: name: White, Michael A.
name: Steffy, Brian
name: Wiltshire, Tim
name: Payseur, Bret A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Reproductive isolation between species is often caused by deleterious interactions among loci in hybrids. Finding the genes involved in these incompatibilities provides insight into the mechanisms of speciation. With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive isolation early in the speciation process. Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have been restricted to F1 sterility or incompatibilities involving the X chromosome. To provide a more complete characterization of this key reproductive barrier, we conducted an F2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus. We identified a suite of autosomal and X-linked QTL that underlie measures of hybrid male sterility, including testis weight, sperm density, and sperm morphology. In many cases, the autosomal loci were unique to a specific sterility trait and exhibited an effect only when homozygous, underscoring the importance of examining reproductive barriers beyond the F1 generation. We also found novel two-locus incompatibilities between the M. m. musculus X chromosome and M. m. domesticus autosomal alleles. Our results reveal a complex genetic architecture for hybrid male sterility and suggest a prominent role for reproductive barriers in advanced generations in maintaining subspecies integrity in house mice.
Noise transfer for unsupervised domain adaptation of retinal OCT images
Creators: name: Koch, Valentin
name: Holmberg, Olle
name: Spitzer, Hannah
name: Schiefelbein, Johannes
name: Asani, Ben
name: Hafner, Michael
name: Theis, Fabian J
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Optical coherence tomography (OCT) imaging from different camera devices causes challenging domain shifts and can cause a severe drop in accuracy for machine learning models. In this work, we introduce a minimal noise adaptation method based on a singular value decomposition (SVDNA) to overcome the domain gap between target domains from three different device manufacturers in retinal OCT imaging. Our method utilizes the difference in noise structure to successfully bridge the domain gap between different OCT devices and transfer the style from unlabeled target domain images to source images for which manual annotations are available. We demonstrate how this method, despite its simplicity, compares or even outperforms state-of-the-art unsupervised domain adaptation methods for semantic segmentation on a public OCT dataset. SVDNA can be integrated with just a few lines of code into the augmentation pipeline of any network which is in contrast to many state-of-the-art domain adaptation methods which often need to change the underlying model architecture or train a separate style transfer model. The full code implementation for SVDNA is available at https://github.com/ValentinKoch/SVDNA.
description: published at MICCAI 2022
Imperfect World of $ββ$-decay Nuclear Data Sets?
Creators: name: Pritychenko, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The precision of double-beta ($ββ$) decay experimental half-lives and their uncertainties is reevaluated. A complementary analysis of the decay uncertainties indicates deficiencies due to small size of statistical samples, and incomplete collection of experimental information. Further experimental and theoretical efforts would lead toward more precise values of $ββ$-decay half-lives and nuclear matrix elements.
description: 4 pages, 2 figures, 2 tables
The Effect of Stars on the Dark Matter Spike Around a Black Hole: A Tale of Two Treatments
Creators: name: Shapiro, Stuart L.
name: Heggie, Douglas C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revisit the role that gravitational scattering off stars plays in establishing the steady-state distribution of collisionless dark matter (DM) around a massive black hole (BH). This is a physically interesting problem that has potentially observable signatures, such as $γ-$rays from DM annihilation in a density spike. The system serves as a laboratory for comparing two different dynamical approaches, both of which have been widely used: a Fokker-Planck treatment and a two-component conduction fluid treatment. In our Fokker-Planck analysis we extend a previous analytic model to account for a nonzero flux of DM particles into the BH, as well as a cut-off in the distribution function near the BH due to relativistic effects or, further out, possible DM annihilation. In our two-fluid analysis, following an approximate analytic treatment, we recast the equations as a "heated Bondi accretion" problem and solve the equations numerically without approximation. While both the Fokker-Planck and two-fluid methods yield basically the same DM density and velocity dispersion profiles away from the boundaries in the spike interior, there are other differences, especially the determination of the DM accretion rate. We discuss limitations of the two treatments, including the assumption of an isotropic velocity dispersion.
description: 12 pages, 6 figures
Pinocchio in Greece: Modern Literary Depictions of the Classic Hero Translated and Retranslated into Greek
Creators: name: Korka, Nikoletta
Publisher: name: iNTERCULTURAL tRANSLATION iNTERSEMIOTIC
Year: 2023

description: In Greece we find numerous adaptations of 19th century works addressed to underage readers, an example being Collodis’ famous work, The Adventures of Pinocchio. The main goal of this paper is to identify translations of Collodis' work into Greek for minors and highlight the translation techniques adopted by translators. To that end, the present paper draws methodological tools from the field of interlingual translation and, more specifically, from the theory of "Descriptive Translation Studies". We divided our study material into two chronological categories: the period of 1931-2004, and the period 2005-2021. Important information was also obtained from iconographic representations and paratextual data of the books, as they make up for a large part of the narration and reveal details regarding the translation techniques.
description: iNTERCULTURAL tRANSLATION iNTERSEMIOTIC, Vol 12, No 1 (2023)
Der Papst über die Grundlage und Bedeutung eines gesunden Bauernstandes
Creators: name: Pius XII., Papst
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 1 Nr. 6/7 (1946): Herder Korrespondenz, Band 1, Heft 6/7
Next-Generation Mapping of Complex Traits with Phenotype-Based Selection and Introgression
Creators: name: Jones, Corbin D.
name: Earley, Eric J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Finding the genes underlying complex traits is difficult. We show that new sequencing technology combined with traditional genetic techniques can efficiently identify genetic regions underlying a complex and quantitative behavioral trait. As a proof of concept we used phenotype-based introgression to backcross loci that control innate food preference in Drosophila simulans into the genomic background of D. sechellia, which expresses the opposite preference. We successfully mapped D. simulans introgression regions in a small mapping population (30 flies) with whole-genome resequencing using light coverage (∼1×). We found six loci contributing to D. simulans food preference, one of which overlaps a previously discovered allele. This approach is applicable to many systems, does not rely on laborious marker development or genotyping, does not require existing high quality reference genomes, and needs only small mapping populations. Because introgression is used, researchers can scale mapping population size, replication, and number of backcross generations to their needs. Finally, in contrast to more widely used mapping techniques like F2 bulk-segregant analysis, our method produces near-isogenic lines that can be kept and reused indefinitely.
ผลสัมฤทธิ์ทางการเรียนและความพึงพอใจของนักเรียนในการเรียนรู้แบบสะเต็มศึกษาโดยผ่านกระบวนการสร้างสังคมแห่งการเรียนรู้ทางวิชาชีพในรายวิชาเคมีสำหรับนักเรียนระดับชั้นมัธยมศึกษาตอนปลายในภาคใต้ของประเทศไทย ในช่วงที่มีการระบาดของโคโรนาไวรัส
Creators: name: ปิยศิริ สุนทรนนท์ สินไชย
Publisher: name: ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: สะเต็มศึกษา
กระบวนการสร้างสังคมแห่งการเรียนรู้ทางวิชาชีพ
นักเรียนระดับชั้นมัธยมศึกษา

description: วารสารครุศาสตร์, 51, 1, EDUCU5101009 (12 pages)
ВЛИЯНИЕ НОРМ МЕЖДУНАРОДНОГО ПРАВАНА ПРАВОВОЕ РЕГУЛИРОВАНИЕ ТРУДА ИНОСТРАННЫХ ГРАЖДАН В РОССИИ
Creators: name: Майстренко Г.А.
name: Майстренко А.Г.
Publisher: name: Право и управление
Year: 2022
Subjects: закон
трудовой иммигрант
государство
правовой акт
трудовой договор
права граждан.

description: В статье рассматривается правовая база стран Европейского Союза и Содружества Независимых Государств, по правовой регламентации трудовых отношений с иностранными гражданами. Авторы проводят анализ правовой базы отдельных европейских государств, государств постсоветского пространства, Китая и Вьетнама. В большинстве правовых актах рассматриваются вопросы применения национального режима иностранных работников, оформления трудовых отношений, а также вопросы возмещения работнику ущерба вследствие получения увечья во время исполнения трудовых обязанностей.
Der Papst über die Wiederherstellung eines dauerhaften Friedens (Weihnachtsansprache 24.12.1946)
Creators: name: Pius XII., Papst
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 1 Nr. 6/7 (1946): Herder Korrespondenz, Band 1, Heft 6/7
FAIR for AI: An interdisciplinary and international community building perspective
Creators: name: Huerta, E. A.
name: Blaiszik, Ben
name: Brinson, L. Catherine
name: Bouchard, Kristofer E.
name: Diaz, Daniel
name: Doglioni, Caterina
name: Duarte, Javier M.
name: Emani, Murali
name: Foster, Ian
name: Fox, Geoffrey
name: Harris, Philip
name: Heinrich, Lukas
name: Jha, Shantenu
name: Katz, Daniel S.
name: Kindratenko, Volodymyr
name: Kirkpatrick, Christine R.
name: Lassila-Perini, Kati
name: Madduri, Ravi K.
name: Neubauer, Mark S.
name: Psomopoulos, Fotis E.
name: Roy, Avik
name: Rübel, Oliver
name: Zhao, Zhizhen
name: Zhu, Ruike
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: Machine Learning (cs.LG)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: I.2.0; E.0

description: A foundational set of findable, accessible, interoperable, and reusable (FAIR) principles were proposed in 2016 as prerequisites for proper data management and stewardship, with the goal of enabling the reusability of scholarly data. The principles were also meant to apply to other digital assets, at a high level, and over time, the FAIR guiding principles have been re-interpreted or extended to include the software, tools, algorithms, and workflows that produce data. FAIR principles are now being adapted in the context of AI models and datasets. Here, we present the perspectives, vision, and experiences of researchers from different countries, disciplines, and backgrounds who are leading the definition and adoption of FAIR principles in their communities of practice, and discuss outcomes that may result from pursuing and incentivizing FAIR AI research. The material for this report builds on the FAIR for AI Workshop held at Argonne National Laboratory on June 7, 2022.
description: 10 pages, comments welcome!; v2: 12 pages, accepted to Scientific Data
Overcoming Redundancy: An RNAi Enhancer Screen for Morphogenesis Genes in Caenorhabditis elegans
Creators: name: Glass, Stephanie
name: Starostina, Natalia G.
name: White, Noor D.
name: Li, Trudy
name: Jones, Corbin D.
name: Goldstein, Bob
name: Kipreos, Edward T.
name: Sawyer, Jacob M.
name: Shemer, Gidi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Morphogenesis is an important component of animal development. Genetic redundancy has been proposed to be common among morphogenesis genes, posing a challenge to the genetic dissection of morphogenesis mechanisms. Genetic redundancy is more generally a challenge in biology, as large proportions of the genes in diverse organisms have no apparent loss of function phenotypes. Here, we present a screen designed to uncover redundant and partially redundant genes that function in an example of morphogenesis, gastrulation in Caenorhabditis elegans. We performed an RNA interference (RNAi) enhancer screen in a gastrulation-sensitized double-mutant background, targeting genes likely to be expressed in gastrulating cells or their neighbors. Secondary screening identified 16 new genes whose functions contribute to normal gastrulation in a nonsensitized background. We observed that for most new genes found, the closest known homologs were multiple other C. elegans genes, suggesting that some may have derived from rounds of recent gene duplication events. We predict that such genes are more likely than single copy genes to comprise redundant or partially redundant gene families. We explored this prediction for one gene that we identified and confirmed that this gene and five close relatives, which encode predicted substrate recognition subunits (SRSs) for a CUL-2 ubiquitin ligase, do indeed function partially redundantly with each other in gastrulation. Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes.
Mechanical tuning of the evaporation rate of liquid on crossed fibers
Creators: name: Boulogne, François
name: Sauret, Alban
name: Soh, Beatrice
name: Dressaire, Emilie
name: Stone, Howard A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We investigate experimentally the drying of a small volume of perfectly wetting liquid on two crossed fibers. We characterize the drying dynamics for the three liquid morphologies that are encountered in this geometry: drop, column and a mixed morphology, in which a drop and a column coexist. For each morphology, we rationalize our findings with theoretical models that capture the drying kinetics. We find that the evaporation rate depends significantly on the liquid morphology and that the drying of liquid column is faster than the evaporation of the drop and the mixed morphology for a given liquid volume. Finally, we illustrate that shearing a network of fibers reduces the angle between them, changes the morphology towards the column state, and so enhances the drying rate of a volatile liquid deposited on it.
ВЛИЯНИЕ ТРУДОВ НЕМЕЦКОГО УЧЕНОГО РУДОЛЬФА ФОН ИЕРИНГА НА РОССИЙСКУЮ ПРАВОВУЮ ДОКТРИНУ ДОГОВОРА
Creators: name: Цветков И.Г.
Publisher: name: Право и управление
Year: 2022
Subjects: Р. Иеринг
договор
история права
Российская империя
цивилисты
доктрина договора
право XIX века.

description: Статья посвящена межотраслевому исследованию влияния трудов немецкого ученого Рудольфа фон Иеринга на гражданско-правовой институт договора в истории российского права периода последней трети XIX начале XX века. Данное влияние заслуживает особого научного внимания, поскольку в трудах российских цивилистов периода последней трети XIX начала XX века широко исследовалась западноевропейская модель право понимания. Особую роль и значительное количество обращений шли к трудам Рудольфа фон Иеринга. В статье проанализированы работы дореволюционных российских и западных юристов: Р. Иеринга, С.А. Муромцева, Г.Ф. Шершеневича, К.П. Победоносцева, С.В. Пахмана, Ю.С. Гамбарова, Г. Мейера и др. Журналы Редакционной комиссии по составлению проекта Гражданского уложения и комментарии к нему.
Transferring organs of a dead clinically in Islamic Fiqh
Creators: name: Ezzaky, Abdellah
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 500403
subject: Islamic studies

description: This research attempts to identify The Fiqh position of transferring the organs of thedeceased ; clinical death ( dead clinically) and compare it with the civil law.
We have seen through this study that adopting the concept of brain death achieves anumber of results, the most important of which are:
-Saving the cost of caring for cases of brain dead ( dead clinically) in resuscitation rooms,without any benefit whatsoever, from their continued survival on industrial resuscitation devices, at a time when other cases need such intensive care.
Raising the tremendous psychological and practical pressure on the medical staff and the family of the deceased.- Most of the Sharia fatwas adopted the concept of brain death ( dead clinically) and considered it equal to the death of the heart, which has achieved great benefit for many of the beneficiaries of organ transplantation of the deceased with a brain death ( dead clinically).
Precise measurement of the 222Rn half-life: a probe to monitor the stability of radioactivity
Creators: name: Bellotti, E.
name: Broggini, C.
name: Di Carlo, G.
name: Laubenstein, M.
name: Menegazzo, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We give the results of a study on the 222Rn decay we performed in the Gran Sasso Laboratory (LNGS) by detecting the gamma rays from the radon progeny. The motivation was to monitor the stability of radioactivity measuring several times per year the half-life of a short lifetime (days) source instead of measuring over a long period the activity of a long lifetime (tens or hundreds of years) source. In particular, we give a possible reason of the large periodical fluctuations in the count rate of the gamma rays due to radon inside a closed canister which has been described in literature and which has been attributed to a possible influence of a component in the solar irradiation affecting the nuclear decay rates. We then provide the result of four half-life measurements we performed underground at LNGS in the period from May 2014 to January 2015 with radon diffused into olive oil. Briefly, we did not measure any change of the 222Rn half-life with a 8*10^-5 precision. Finally, we provide the most precise value for the 222Rn half-life: 3.82146(16){stat}(4){syst} days.
description: Accepted for publication in Physics Letters B, 6 pages, 6 figures
Transcription Initiation From Within P Elements Generates Hypomorphic Mutations in Drosophila melanogaster
Creators: name: LaFave, Matthew C.
name: Sekelsky, Jeff
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Numerous transposable element insertions in Drosophila melanogaster cause hypomorphic mutations. We report that transcription initiation within a region found in many P-element constructs provides an explanation for why some gene function is retained. We detected evidence of this transcription in four different types of P constructs, regardless of whether the insertion was in a coding exon, intron, 5′ untranslated region, or upstream of the gene span.
A General Bayesian Approach to Analyzing Diallel Crosses of Inbred Strains
Creators: name: Lenarcic, Alan B.
name: Valdar, William
name: Churchill, Gary A.
name: Svenson, Karen L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The classic diallel takes a set of parents and produces offspring from all possible mating pairs. Phenotype values among the offspring can then be related back to their respective parentage. When the parents are diploid, sexed, and inbred, the diallel can characterize aggregate effects of genetic background on a phenotype, revealing effects of strain dosage, heterosis, parent of origin, epistasis, and sex-specific versions thereof. However, its analysis is traditionally intricate, unforgiving of unplanned missing information, and highly sensitive to imbalance, making the diallel unapproachable to many geneticists. Nonetheless, imbalanced and incomplete diallels arise frequently, albeit unintentionally, as by-products of larger-scale experiments that collect F1 data, for example, pilot studies or multiparent breeding efforts such as the Collaborative Cross or the Arabidopsis MAGIC lines. We present a general Bayesian model for analyzing diallel data on dioecious diploid inbred strains that cleanly decomposes the observed patterns of variation into biologically intuitive components, simultaneously models and accommodates outliers, and provides shrinkage estimates of effects that automatically incorporate uncertainty due to imbalance, missing data, and small sample size. We further present a model selection procedure for weighing evidence for or against the inclusion of those components in a predictive model. We evaluate our method through simulation and apply it to incomplete diallel data on the founders and F1's of the Collaborative Cross, robustly characterizing the genetic architecture of 48 phenotypes.
Improving the LSST dithering pattern and cadence for dark energy studies
Creators: name: Carroll, Christopher M.
name: Gawiser, Eric
name: Kurczynski, Peter L.
name: Bailey, Rachel A.
name: Biswas, Rahul
name: Cinabro, David
name: Jha, Saurabh W.
name: Jones, R. Lynne
name: Krughoff, K. Simon
name: Sonawalla, Aneesa
name: Wood-Vasey, W. Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Large Synoptic Survey Telescope (LSST) will explore the entire southern sky over 10 years starting in 2022 with unprecedented depth and time sampling in six filters, $ugrizy$. Artificial power on the scale of the 3.5 deg LSST field-of-view will contaminate measurements of baryonic acoustic oscillations (BAO), which fall at the same angular scale at redshift $z \sim 1$. Using the HEALPix framework, we demonstrate the impact of an "un-dithered" survey, in which $17\%$ of each LSST field-of-view is overlapped by neighboring observations, generating a honeycomb pattern of strongly varying survey depth and significant artificial power on BAO angular scales. We find that adopting large dithers (i.e., telescope pointing offsets) of amplitude close to the LSST field-of-view radius reduces artificial structure in the galaxy distribution by a factor of $\sim$10. We propose an observing strategy utilizing large dithers within the main survey and minimal dithers for the LSST Deep Drilling Fields. We show that applying various magnitude cutoffs can further increase survey uniformity. We find that a magnitude cut of $r < 27.3$ removes significant spurious power from the angular power spectrum with a minimal reduction in the total number of observed galaxies over the ten-year LSST run. We also determine the effectiveness of the observing strategy for Type Ia SNe and predict that the main survey will contribute $\sim$100,000 Type Ia SNe. We propose a concentrated survey where LSST observes one-third of its main survey area each year, increasing the number of main survey Type Ia SNe by a factor of $\sim$1.5, while still enabling the successful pursuit of other science drivers.
description: 9 pages, 6 figures, published in SPIE proceedings; corrected typo in equation 2
Comparative Oncogenomics Implicates the Neurofibromin 1 Gene (NF1) as a Breast Cancer Driver
Creators: name: Fallon, B. L.
name: Southard, T. L.
name: Pfefferle, A. D.
name: Schimenti, J. C.
name: McNairn, A. J.
name: Cerami, E. G.
name: Wallace, M. D.
name: Rinaldi, V. D.
name: Perou, C. M.
name: Shen, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Identifying genomic alterations driving breast cancer is complicated by tumor diversity and genetic heterogeneity. Relevant mouse models are powerful for untangling this problem because such heterogeneity can be controlled. Inbred Chaos3 mice exhibit high levels of genomic instability leading to mammary tumors that have tumor gene expression profiles closely resembling mature human mammary luminal cell signatures. We genomically characterized mammary adenocarcinomas from these mice to identify cancer-causing genomic events that overlap common alterations in human breast cancer. Chaos3 tumors underwent recurrent copy number alterations (CNAs), particularly deletion of the RAS inhibitor Neurofibromin 1 (Nf1) in nearly all cases. These overlap with human CNAs including NF1, which is deleted or mutated in 27.7% of all breast carcinomas. Chaos3 mammary tumor cells exhibit RAS hyperactivation and increased sensitivity to RAS pathway inhibitors. These results indicate that spontaneous NF1 loss can drive breast cancer. This should be informative for treatment of the significant fraction of patients whose tumors bear NF1 mutations.
Nuclear effects in neutrinoproduction of pions
Creators: name: Schmidt, Ivan
name: Siddikov, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we study nuclear effects in the neutrinoproduction of pions. We found that in a Bjorken kinematics, for moderate $x_{B}$ accessible in ongoing and forthcoming neutrino experiments the cross-section is dominated by the incoherent contribution; the coherent contribution becomes visible only for small $|t|\lesssim1/R_{A}^{2}$, which requires $x_{B}\lesssim0.1$. Our results could be relevant to the kinematics of the ongoing MINERvA experiment in ME configuration. We provide a code which could be used for evaluation of the $ν$DVMP observables using different parametrizations of GPDs and different models of nuclear structure.
description: 7 pages, 4 figures. Minor corrections in text. Accepted for publication in PRD
Universality in the dynamics of vesicle translocation through a hole
Creators: name: Zheng, Bin
name: Ye, Fangfu
name: Komura, Shigeyuki
name: Doi, Masao
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: We analyze the translocation process of a spherical vesicle, made of membrane and incompressible fluid, through a hole smaller than the vesicle size, driven by pressure difference $ΔP$. We show that such a vesicle shows certain universal characteristics which is independent of the details of the membrane elasticity; (i) there is a critical pressure $ΔP_{\rm c}$ below which no translocation occurs, (ii) $ΔP_{\rm c}$ decreases to zero as the vesicle radius $R_0$ approaches the hole radius $a$, satisfying the scaling relation $ΔP_{\rm c} \sim (R_0 - a)^{3/2}$, and (iii) the translocation time $τ$ diverges as $ΔP$ decreases to $ΔP_{\rm c}$, satisfying the scaling relation $τ\sim (ΔP -ΔP_{\rm c})^{-1/2}$.
ГРАЖДАНСКИЕ ПРАВА ИНОСТРАННЫХ КОЛОНИСТОВ В РОССИИ ВТ. ПОЛ. XVIII В.: СРАВНИТЕЛЬНО-ПРАВОВОЙ АСПЕКТ
Creators: name: Пасько Е.А.
Publisher: name: Право и управление
Year: 2022
Subjects: колонист
иностранец
политика переселения
Свод законов Российской империи
привилегия
льгота
российское законодательство
Канцелярия Опекунства иностранных колонистов
политика меркантилизма
подданство
религиозная толерантность
гражданские права
Манифест.

description: Вопросы миграционной политики актуальны в современном мире. Право гражданина на миграцию современной России закреплено Конституцией РФ. В течение длительного времени государство целенаправленно занималось колонизационной политикой, уделяя ей особое внимание. Потребности общества вынуждали правительство, время от времени, активизировать законодательство о переселенцах. Итогом колонизации стало: разрешение проблемы дефицита населения на новых территориях, укрепление обороноспособности юго-западных границ от внешних врагов, сокращение экономического отставания России от стран Западной Европы, внедрение передовых технологий в некоторых отраслях обрабатывающей промышленности и земледелии, расширение торгового сектора экономики. В последующие годы государство занималось кодификацией законодательства о колонистах, которое стало неотъемлемой частью российского права. Таким образом, можно подчеркнуть, что колонизационная политика оставила глубокий след в истории страны.
Surface Acoustic Waves Equip Materials with Active Deicing Functionality: Unraveled Deicing Mechanisms and Application to Centimeter Scale Transparent Surfaces
Creators: name: Jacob, Stefan
name: Pandey, Shilpi
name: Del Moral, Jaime
name: Karimzadeh, Atefeh
name: Gil-Rostra, Jorge
name: González-Elipe, Agustín R.
name: Borrás, Ana
name: Winkler, Andreas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Migrating active deicing capabilities to transparent materials with low thermal conductivity has a high potential to improve the operations of several seminal industries in the automotive, robotic, energy, and aerospace sectors. However, the development of efficient and environmentally friendly deicing methods is yet in its infancy regarding their compatibility with end-user surfaces at relevant scales and real-world operations. Herein, we approach deicing through nanoscale surface activation enabled by surface acoustic waves (SAWs), allowing efficient on-demand deicing of surface areas spanning several square centimeters covered with thick layers of glace ice. We contemplate SAW-based deicing from a twofold perspective: First, we demonstrate its functionality both with a bulk piezoelectric material (LiNbO3) and a piezo-electric film (ZnO), the latter proving its versatile applicability to a large variety of functional materials with practical importance; second, we gain fundamental knowledge of the mechanisms responsible for efficient deicing using SAWs. In particular, we show that SAW vibrational modes easily transport energy over greater distances outside the electrode areas and efficiently melt large ice aggregates covering the materials' surfaces. In addition, the essential physics of SAW-based deicing is inferred from a carefully designed experimental and numerical study. We support our findings by providing macroscopic camera snapshots captured in situ inside a climate chamber during deicing and highly resolved laser-doppler vibrometer scans of the undisturbed wavefields at room temperature. Great care was taken to deposit the interdigital transducers (IDTs) used for SAW excitation only on ice-free areas close to the chip edges, leaving most of the substrate used for deicing unaltered and, as a matter of fact, demonstrating transparent deicing solutions.
description: 15 pages including Supporting Information; 7 figures in the main text
DNA Replication Origin Function Is Promoted by H3K4 Di-methylation in Saccharomyces cerevisiae
Creators: name: Cook, J. G.
name: Dorn, E. S.
name: Strahl, B. D.
name: Rizzardi, L. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: DNA replication is a highly regulated process that is initiated from replication origins, but the elements of chromatin structure that contribute to origin activity have not been fully elucidated. To identify histone post-translational modifications important for DNA replication, we initiated a genetic screen to identify interactions between genes encoding chromatin-modifying enzymes and those encoding proteins required for origin function in the budding yeast Saccharomyces cerevisiae. We found that enzymes required for histone H3K4 methylation, both the histone methyltransferase Set1 and the E3 ubiquitin ligase Bre1, are required for robust growth of several hypomorphic replication mutants, including cdc6-1. Consistent with a role for these enzymes in DNA replication, we found that both Set1 and Bre1 are required for efficient minichromosome maintenance. These phenotypes are recapitulated in yeast strains bearing mutations in the histone substrates (H3K4 and H2BK123). Set1 functions as part of the COMPASS complex to mono-, di-, and tri-methylate H3K4. By analyzing strains lacking specific COMPASS complex members or containing H2B mutations that differentially affect H3K4 methylation states, we determined that these replication defects were due to loss of H3K4 di-methylation. Furthermore, histone H3K4 di-methylation is enriched at chromosomal origins. These data suggest that H3K4 di-methylation is necessary and sufficient for normal origin function. We propose that histone H3K4 di-methylation functions in concert with other histone post-translational modifications to support robust genome duplication.
Energy-Dependent Modulation of Glucagon-Like Signaling in Drosophila via the AMP-Activated Protein Kinase
Creators: name: Alberto, G. E.
name: Johnson, E. C.
name: Gillespie, E. L.
name: Braco, J. T.
name: Brenman, J. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Adipokinetic hormone (AKH) is the equivalent of mammalian glucagon, as it is the primary insect hormone that causes energy mobilization. In Drosophila, current knowledge of the mechanisms regulating AKH signaling is limited. Here, we report that AMP-activated protein kinase (AMPK) is critical for normal AKH secretion during periods of metabolic challenges. Reduction of AMPK in AKH cells causes a suite of behavioral and physiological phenotypes resembling AKH cell ablations. Specifically, reduced AMPK function increases life span during starvation and delays starvation-induced hyperactivity. Neither AKH cell survival nor gene expression is significantly impacted by reduced AMPK function. AKH immunolabeling was significantly higher in animals with reduced AMPK function; this result is paralleled by genetic inhibition of synaptic release, suggesting that AMPK promotes AKH secretion. We observed reduced secretion in AKH cells bearing AMPK mutations employing a specific secretion reporter, confirming that AMPK functions in AKH secretion. Live-cell imaging of wild-type AKH neuroendocrine cells shows heightened excitability under reduced sugar levels, and this response was delayed and reduced in AMPK-deficient backgrounds. Furthermore, AMPK activation in AKH cells increases intracellular calcium levels in constant high sugar levels, suggesting that the underlying mechanism of AMPK action is modification of ionic currents. These results demonstrate that AMPK signaling is a critical feature that regulates AKH secretion, and, ultimately, metabolic homeostasis. The significance of these findings is that AMPK is important in the regulation of glucagon signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks.
Functional Genomic Architecture of Predisposition to Voluntary Exercise in Mice: Expression QTL in the Brain
Creators: name: Hua, K.
name: Garland, T.
name: Kelly, S. A.
name: Nehrenberg, D. L.
name: Pomp, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The biological basis of voluntary exercise is complex and simultaneously controlled by peripheral (ability) and central (motivation) mechanisms. The accompanying natural reward, potential addiction, and the motivation associated with exercise are hypothesized to be regulated by multiple brain regions, neurotransmitters, peptides, and hormones. We generated a large (n = 815) advanced intercross line of mice (G4) derived from a line selectively bred for increased wheel running (high runner) and the C57BL/6J inbred strain. We previously mapped multiple quantitative trait loci (QTL) that contribute to the biological control of voluntary exercise levels, body weight, and composition, as well as changes in body weight and composition in response to short-term exercise. Currently, using a subset of the G4 population (n = 244), we examined the transcriptional landscape relevant to neurobiological aspects of voluntary exercise by means of global mRNA expression profiles from brain tissue. We identified genome-wide expression quantitative trait loci (eQTL) regulating variation in mRNA abundance and determined the mode of gene action and the cis- and/or trans-acting nature of each eQTL. Subsets of cis-acting eQTL, colocalizing with QTL for exercise or body composition traits, were used to identify candidate genes based on both positional and functional evidence, which were further filtered by correlational and exclusion mapping analyses. Specifically, we discuss six plausible candidate genes (Insig2, Socs2, DBY, Arrdc4, Prcp, IL15) and their potential role in the regulation of voluntary activity, body composition, and their interactions. These results develop a potential initial model of the underlying functional genomic architecture of predisposition to voluntary exercise and its effects on body weight and composition within a neurophysiological framework.
Predicting the whispering gallery mode spectra of microresonators
Creators: name: Hall, Jonathan M. M.
name: V., Shahraam Afshar
name: Henderson, Matthew R.
name: Francois, Alexandre
name: Reynolds, Tess
name: Riesen, Nicolas
name: Monro, Tanya M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The whispering gallery modes (WGMs) of optical resonators have prompted intensive research efforts due to their usefulness in the field of biological sensing, and their employment in nonlinear optics. While much information is available in the literature on numerical modeling of WGMs in microspheres, it remains a challenging task to be able to predict the emitted spectra of spherical microresonators. Here, we establish a customizable Finite- Difference Time-Domain (FDTD)-based approach to investigate the WGM spectrum of microspheres. The simulations are carried out in the vicinity of a dipole source rather than a typical plane-wave beam excitation, thus providing an effective analogue of the fluorescent dye or nanoparticle coatings used in experiment. The analysis of a single dipole source at different positions on the surface or inside a microsphere, serves to assess the relative efficiency of nearby radiating TE and TM modes, characterizing the profile of the spectrum. By varying the number, positions and alignments of the dipole sources, different excitation scenarios can be compared to analytic models, and to experimental results. The energy flux is collected via a nearby disk-shaped region. The resultant spectral profile shows a dependence on the configuration of the dipole sources. The power outcoupling can then be optimized for specific modes and wavelength regions. The development of such a computational tool can aid the preparation of optical sensors prior to fabrication, by preselecting desired the optical properties of the resonator.
description: Approved version for SPIE Photonics West, LASE, Laser Resonators, Microresonators and Beam Control XVI
High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population
Creators: name: Churchill, Gary A.
name: Welsh, Catherine E.
name: Chesler, Elissa J.
name: Valdar, William
name: McMillan, Leonard
name: Svenson, Karen L.
name: Cheng, Riyan
name: Gatti, Daniel M.
name: Palmer, Abraham A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The JAX Diversity Outbred population is a new mouse resource derived from partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it segregates the same allelic variants as the Collaborative Cross but embeds these in a distinct population architecture in which each animal has a high degree of heterozygosity and carries a unique combination of alleles. Phenotypic diversity is striking and often divergent from phenotypes seen in the founder strains of the Collaborative Cross. Allele frequencies and recombination density in early generations of Diversity Outbred mice are consistent with expectations based on simulations of the mating design. We describe analytical methods for genetic mapping using this resource and demonstrate the power and high mapping resolution achieved with this population by mapping a serum cholesterol trait to a 2-Mb region on chromosome 3 containing only 11 genes. Analysis of the estimated allele effects in conjunction with complete genome sequence data of the founder strains reduced the pool of candidate polymorphisms to seven SNPs, five of which are located in an intergenic region upstream of the Foxo1 gene.
«ДАЛЬНЕВОСТОЧНЫЙ ГЕКТАР», КАК СПОСОБ ПРАВОВОГО СТИМУЛИРОВАНИЯ ГРАЖДАН ДЛЯ ДОСТИЖЕНИЯ ЭКОНОМИЧЕСКИХ ЦЕЛЕЙ РФ
Creators: name: Москаленко С.П.
name: Рогозная Д.Е.
name: Малахов А.В.
Publisher: name: Право и управление
Year: 2022
Subjects: Дальневосточный Гектар
Дальний Восток
земельный участок
земельное право
экономика
земля.

description: В настоящей статье авторы исследуют особенности экономической и правовой природы программы по безвозмездному выделению земельных участков гражданам Российской Федерации «Дальневосточный Гектар». В ходе исследования авторы изучают нормативно-правовые акты, регулирующие программу, а также выделяют наиболее уязвимые с правовой точки зрения места в программе «Дальневосточный Гектар». Основополагающим документом при изучении «Дальневосточного Гектара» выступают статьи Федерального закона №119-ФЗ «Об особенностях предоставления гражданам земельных участков, находящихся в государственной или муниципальной собственности и расположенных в Арктической зоне Российской Федерации и на других территориях Севера, Сибири и Дальнего Востока Российской Федерации, и о внесении изменений в отдельные законодательные акты Российской Федерации».