cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(2959) Elizabeth Helen Miller
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Tables from Physical trade-offs shape the evolution of buoyancy control in sharks.
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
LA NIÑA PERDIDA (DOS MUJERES 4) ePub gratis
Creators: name: Furey
Publisher: name: Zenodo
Year: 2024

description: LA NIÑA PERDIDA (DOS MUJERES 4) de ELENA FERRANTE

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LA NIÑA PERDIDA (DOS MUJERES 4)

ELENA FERRANTE

Número de páginas: 544

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788426402158

Editorial: LUMEN

Año de edición: 2018

 

 

 

 

 

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Overview

 

La niña perdida pone punto final a «Dos mujeres», la historia de dos amigas que nacieron a mediados del siglo XX en Nápoles y desde pequeñas fueron compartiendo una amistad compleja, con momentos de duda o ausencia, pero siempre cómplices.

Lina y Elena son ahora adultas y han tomado caminos distintos: Elena dejó Nápoles para casarse y convertirse en una escritora de éxito en Milán. Solo un amor de juventud que vuelve a florecer la devolverá a Nápoles, donde la espera Lina, que ahora es madre y además ha triunfado muy a su manera en el negocio local. Elena es la señora culta, Lina es en apariencia la mujer de barrio, ignorante y poco dispuesta al refinamiento, pero la inteligencia pura y la intuición están del lado de Lina.

Los hechos se precipitan cuando un buen día de repente, la hija de Lina desaparece: ¿asesinato, rapto, muerte? Nadie sabe, y el barrio murmura. Desde entonces, Lina ya no es la misma y la locura acecha. Todo -los hombres, las mujeres, el paisaje, la ciudad entera de Nápoles- se convierten en testigos del duelo de una madre que no sabe llorar y un buen día también desaparecerá, devolviendo al lector a las primeras páginas de esta espléndida saga.

Inteligencia, emoción contenida, escritura que se pliega a los acontecimientos y se ajusta como un guante a la trama: todo está en estas páginas donde se ha ido cosiendo una de las obras más brillantes del siglo XXI.
The effect of different eLISA-like configurations on massive black hole parameter estimation
Creators: name: Porter, Edward K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: As the theme for the future L3 Cosmic Vision mission, ESA has recently chosen the `Gravitational Wave Universe'. Within this call, a mission concept called eLISA has been proposed. This observatory has a current initial configuration consisting of 4 laser links between the three satellites, which are separated by a distance of one million kilometers, constructing a single channel Michelson interferometer. However, the final configuration for the observatory will not be fixed until the end of this decade. With this in mind, we investigate the effect of different eLISA-like configurations on massive black hole detections. This work compares the results of a Bayesian inference study of 120 massive black hole binaries out to a redshift of $z\sim13$ for a $10^6$m arm-length eLISA with four and six links, as well as a $2\times10^6$m arm-length observatory with four links. We demonstrate that the original eLISA configuration should allow us to recover the luminosity distance of the source with an error of less than 10% out to a redshift of $z\sim4$, and a sky error box of $\leq10^2\,deg^2$ out to $z\sim0.1$. In contrast, both alternative configurations suggest that we should be able to conduct the same parameter recovery with errors of less than 10% in luminosity distance out to $z\sim12$ and $\leq10^2\,deg^2$ out to $z\sim0.4$. Using the information from these studies, we also infer that if we were able to construct a 2Gm, 6-link detector, the above values would shift to $z\sim20$ for luminosity distance and $z\sim0.9$ for sky error. While the final configuration will also be dependent on both technological and financial considerations, our study suggests that increasing the size of a two arm detector is a viable alternative to the inclusion of a third arm in a smaller detector. More importantly, this work further suggests no clear scientific loss between either choice.
description: 9 pages, 5 figures
Descargar ebook UNA CORTE DE ALAS Y RUINA (UNA CORTE DE ROSAS Y ESPINAS 3) | Descarga Libros Gratis (PDF - EPUB)
Creators: name: Williams
Publisher: name: Zenodo
Year: 2024

description: UNA CORTE DE ALAS Y RUINA (UNA CORTE DE ROSAS Y ESPINAS 3) de SARAH J. MAAS

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UNA CORTE DE ALAS Y RUINA (UNA CORTE DE ROSAS Y ESPINAS 3)

SARAH J. MAAS

Número de páginas: 672

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408178699

Editorial: PLANETA

Año de edición: 2017

 

 

 

 

 

Descargar ebook for kindle UNA CORTE DE ALAS Y RUINA (UNA CORTE DE ROSAS Y ESPINAS 3)

 

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La magia de La Bella y la Bestia con la fuerza de George R.R. Martin.Tercera parte de Una corte de rosas y espinas.

Feyre ha vuelto a la Corte Primavera decidida a desvelar las artimañas de Tamlin y las razones del rey que amenaza Prythian. Pero para hacerlo, tendrá que jugar al mortal juego del engaño… un solo paso en falso podría condenarla, no solo a ella sino a todo su mundo. La guerra se cierne sobre todos, y Feyre tendrá que elegir muy bien en quién confiar.
(2960) Florence Emily Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SOX2 maintains the quiescent progenitor cell state of postnatal retinal Muller glia
Creators: name: Langer, Lee
name: Surzenko, Natalia
name: Crowl, Tessa
name: Bachleda, Amelia
name: Pevny, Larysa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Within discrete regions of the developing mammalian central nervous system, small subsets of glia become specialized to function as neural stem cells. As a result of their self-renewal and neurogenic capacity, these cells later serve to replenish neurons and glia during persistent or injury-induced adult neurogenesis. SOX2, an HMG box transcription factor, plays an essential role in the maintenance of both embryonic and adult neural progenitors. It is unclear, however, which biological mechanisms regulated by SOX2 are required for neural stem cell maintenance. In this study, we address this question through genetic analysis of SOX2 function in differentiating postnatal Müller glia, a cell type that maintains neurogenic capacity in the adult retina. By utilizing molecular analysis and real-time imaging, we show that two progenitor characteristics of nascent Müller glia - their radial morphology and cell cycle quiescence - are disrupted following conditional genetic ablation of Sox2 in the mouse postnatal retina, leading to Müller cell depletion and retinal degeneration. Moreover, we demonstrate that genetic induction of the Notch signaling pathway restores Müller glial cell identity to Sox2 mutant cells, but does not secure their quiescent state. Collectively, these results uncouple the roles of SOX2 and the Notch signaling pathway in the postnatal retina, and uncover a novel role for SOX2 in preventing the depletion of postnatal Müller glia through terminal cell division.
Tcf21 regulates the specification and maturation of proepicardial cells
Creators: name: Cristea, Ileana M.
name: Miteva, Yana V.
name: Tandon, Panna
name: Kuchenbrod, Lauren M.
name: Conlon, Frank L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The epicardium is a mesothelial cell layer essential for vertebrate heart development and pertinent for cardiac repair post-injury in the adult. The epicardium initially forms from a dynamic precursor structure, the proepicardial organ, from which cells migrate onto the heart surface. During the initial stage of epicardial development crucial epicardial-derived cell lineages are thought to be determined. Here, we define an essential requirement for transcription factor Tcf21 during early stages of epicardial development in Xenopus, and show that depletion of Tcf21 results in a disruption in proepicardial cell specification and failure to form a mature epithelial epicardium. Using a mass spectrometry-based approach we defined Tcf21 interactions and established its association with proteins that function as transcriptional co-repressors. Furthermore, using an in vivo systems-based approach, we identified a panel of previously unreported proepicardial precursor genes that are persistently expressed in the epicardial layer upon Tcf21 depletion, thereby confirming a primary role for Tcf21 in the correct determination of the proepicardial lineage. Collectively, these studies lead us to propose that Tcf21 functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium.
L 363-38 b: a planet newly discovered with ESPRESSO orbiting a nearby M dwarf star
Creators: name: Sartori, Lia F.
name: Lovis, Christophe
name: Delisle, Jean-Baptiste
name: Lendl, Monika
name: Cugno, Gabriele
name: Boehle, Anna
name: Dannert, Felix
name: Krenn, Andrea
name: Gubler, Jonas L.
name: Quanz, Sascha P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Context. Planets around stars in the solar neighbourhood will be prime targets for characterisation with upcoming large space- and ground-based facilities. Since large-scale exoplanet searches will not be feasible with such telescopes, it is crucial to use currently available data and instruments to find possible target planets before next generation facilities come online. Aims. We aim at detecting new extrasolar planets around stars in the solar neighbourhood by blind radial velocity (RV) search with ESPRESSO. Our target sample consist of nearby stars (d < 11 pc) with little (< 10) or no previous RV measurements. Methods. We use 31 radial velocity measurements obtained with ESPRESSO at the VLT between December 2020 and February 2022 of the nearby M dwarf star (M_star = 0.21 M_sun, d = 10.23 pc) L 363-38 to derive the orbital parameters of the newly discovered planet. In addition, we use TESS photometry and archival VLT/NaCo high contrast imaging data to put further constraints on the orbit inclination and the possible planetary system architecture around L 363-38. Results. We present the detection of a new extrasolar planet orbiting the nearby M dwarf star L 363-38. L 363-38 b is a planet with minimum mass mp sin(i) = 4.67+/-0.43 M_Earth orbiting its star with a period P = 8.781+/-0.007 d, corresponding to a semi-major axis a = 0.048+/-0.006 AU, which is well inside the inner edge of the habitable zone. We further estimate a minimum radius rp sin(i) = 1.55 - 2.75 R_Earth and an equilibrium temperature Teq = 330K.
description: 12 pages, 11 figures
Apical constriction: themes and variations on a cellular mechanism driving morphogenesis
Creators: name: Martin, Adam C.
name: Goldstein, Bob
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates. In recent years, progress has been made towards understanding how the distinct cell biological processes that together drive apical constriction are coordinated. These processes include the contraction of actin-myosin networks, which generates force, and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted between cells. Different cell types regulate contractility and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellular organizations, as well as a variety of resulting tissue shape changes. Understanding both the common themes and the variations in apical constriction mechanisms promises to provide insight into the mechanics that underlie tissue morphogenesis.
Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience
Creators: name: Doe, Chris Q.
name: Pearson, Joseph C.
name: Myers, Eugene
name: Crews, Stephen T.
name: Heckscher, Ellie S.
name: Long, Fuhui
name: Chuang, Chein Hui
name: Manning, Laurina
name: Layden, Michael J.
name: Richart, Jourdain
name: Peng, Hanchuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A major limitation in understanding embryonic development is the lack of cell type-specific markers. Existing gene expression and marker atlases provide valuable tools, but they typically have one or more limitations: a lack of single-cell resolution; an inability to register multiple expression patterns to determine their precise relationship; an inability to be upgraded by users; an inability to compare novel patterns with the database patterns; and a lack of three-dimensional images. Here, we develop new ‘atlas-builder’ software that overcomes each of these limitations. A newly generated atlas is three-dimensional, allows the precise registration of an infinite number of cell type-specific markers, is searchable and is open-ended. Our software can be used to create an atlas of any tissue in any organism that contains stereotyped cell positions. We used the software to generate an ‘eNeuro’ atlas of the Drosophila embryonic CNS containing eight transcription factors that mark the major CNS cell types (motor neurons, glia, neurosecretory cells and interneurons). We found neuronal, but not glial, nuclei occupied stereotyped locations. We added 75 new Gal4 markers to the atlas to identify over 50% of all interneurons in the ventral CNS, and these lines allowed functional access to those interneurons for the first time. We expect the atlas-builder software to benefit a large proportion of the developmental biology community, and the eNeuro atlas to serve as a publicly accessible hub for integrating neuronal attributes – cell lineage, gene expression patterns, axon/dendrite projections, neurotransmitters – and linking them to individual neurons.
A Couplet from Flavored Dark Matter
Creators: name: Agrawal, Prateek
name: Chacko, Zackaria
name: Kilic, Can
name: Verhaaren, Christopher B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that a couplet, a pair of closely spaced photon lines, in the X-ray spectrum is a distinctive feature of lepton flavored dark matter models for which the mass spectrum is dictated by Minimal Flavor Violation. In such a scenario, mass splittings between different dark matter flavors are determined by Standard Model Yukawa couplings and can naturally be small, allowing all three flavors to be long-lived and contribute to the observed abundance. Then, in the presence of a tiny source of flavor violation, heavier dark matter flavors can decay via a dipole transition on cosmological timescales, giving rise to three photon lines. The ratios of the line energies are completely determined in terms of the charged lepton masses, and constitute a firm prediction of this framework. For dark matter masses of order the weak scale, the couplet lies in the keV-MeV region, with a much weaker line in the eV-keV region. This scenario constitutes a potential explanation for the recent claim of the observation of a 3.5 keV line. The next generation of X-ray telescopes may have the necessary resolution to resolve the double line structure of such a couplet.
description: 17 pages, 4 figures, 1 haiku
Supplementary Methods: Comparative Data from Physical trade-offs shape the evolution of buoyancy control in sharks.
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity
Creators: name: Gibbs, Devin
name: Christine, Kathleen S.
name: Amin, Nirav M.
name: Sojka, Stephen
name: Charpentier, Marta S.
name: Conlon, Frank L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The identification and characterization of the cellular and molecular pathways involved in the differentiation and morphogenesis of specific cell types of the developing heart are crucial to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor CASTOR (CASZ1) directly interacts with congenital heart disease 5 protein (CHD5), which is also known as tryptophan-rich basic protein (WRB), a gene located on chromosome 21 in the proposed region responsible for congenital heart disease in individuals with Down's syndrome. We demonstrate that loss of CHD5 in Xenopus leads to compromised myocardial integrity, improper deposition of basement membrane, and a resultant failure of hearts to undergo cell movements associated with cardiac formation. We further report that CHD5 is essential for CASZ1 function and that the CHD5-CASZ1 interaction is necessary for cardiac morphogenesis. Collectively, these results establish a role for CHD5 and CASZ1 in the early stages of vertebrate cardiac development.
Pontryagin's Minimum Principle and Forward-Backward Sweep Method for the System of HJB-FP Equations in Memory-Limited Partially Observable Stochastic Control
Creators: name: Tottori, Takehiro
name: Kobayashi, Tetsuya J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: Memory-limited partially observable stochastic control (ML-POSC) is the stochastic optimal control problem under incomplete information and memory limitation. In order to obtain the optimal control function of ML-POSC, a system of the forward Fokker-Planck (FP) equation and the backward Hamilton-Jacobi-Bellman (HJB) equation needs to be solved. In this work, we firstly show that the system of HJB-FP equations can be interpreted via the Pontryagin's minimum principle on the probability density function space. Based on this interpretation, we then propose the forward-backward sweep method (FBSM) to ML-POSC, which has been used in the Pontryagin's minimum principle. FBSM is an algorithm to compute the forward FP equation and the backward HJB equation alternately. Although the convergence of FBSM is generally not guaranteed, it is guaranteed in ML-POSC because the coupling of HJB-FP equations is limited to the optimal control function in ML-POSC.
Stringent constraint on CPT violation with the synergy of T2K-II, NO$ν$A extension, and JUNO
Creators: name: Ngoc, T. V.
name: Cao, S.
name: Van, N. T. Hong
name: Quyen, P. T.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Neutrino oscillation experiments have measured precisely the mass-squared differences of three neutrino mass eigenstates, and three leptonic mixing angles by utilizing both neutrino and anti-neutrino oscillations. The possible CPT violation may manifest itself in the difference of neutrino and anti-neutrino oscillation parameters, making these experiments promising tools for testing CPT invariance. We investigate empirically the sensitivity of the CPT test via the difference in mass-squared splittings ($Δm^2_{31} - Δ\overline{m}^2_{31}$) and in leptonic mixing angles ($\sin^2θ_{23} - \sin^2\overlineθ_{23}$) with the synergy of T2K-II, NO$ν$A extension, and JUNO experiments. If the CPT symmetry is found to be conserved, the joint analysis of the three experiments will be able to establish limits of $|Δm^2_{31} - Δ\overline{m}^2_{31}|$ < $5.3\times 10^{-3} \text{eV}^2$ and $|\sin^2θ_{23} - \sin^2\overlineθ_{23}|$ < $0.10$ at 3$σ$ C. L. on the possible CPT violation. We find that with ($Δm^2_{31} - Δ\overline{m}^2_{31}$), the dependence of the statistical significance on the relevant parameters to exclude the CPT conservation is marginal, and that, if the difference in the best-fit values of $Δm^2_{31}$ and $Δ\overline{m}^2_{31}$ measured by MINOS(+) and NO$ν$A persists as the true, the combined analysis will rule out the CPT conservation at 4$σ$ C. L.. With the ($\sin^2θ_{23} - \sin^2\overlineθ_{23}$), the statistical significance to exclude CPT invariance depends strongly on the true value of $θ_{23}(\overlineθ_{23})$. In case of maximal mixing of $θ_{23}$, the CPT conservation will be excluded at 3$σ$ C. L. or more if the difference in the best-fit values of $θ_{23}$ and $\overlineθ_{23}$ remains as the true.
description: 10 pages, 10 figures
Supplementary Figures from Physical trade-offs shape the evolution of buoyancy control in sharks.
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
Almanac: Weak Lensing power spectra and map inference on the masked sphere
Creators: name: Loureiro, A.
name: Whiteway, L.
name: Sellentin, E.
name: Lafaurie, J. S.
name: Jaffe, A. H.
name: Heavens, A. F.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a field-based signal extraction of weak lensing from noisy observations on the curved and masked sky. We test the analysis on a simulated Euclid-like survey, using a Euclid-like mask and noise level. To make optimal use of the information available in such a galaxy survey, we present a Bayesian method for inferring the angular power spectra of the weak lensing fields, together with an inference of the noise-cleaned tomographic weak lensing shear and convergence (projected mass) maps. The latter can be used for field-level inference with the aim of extracting cosmological parameter information including non-gaussianity of cosmic fields. We jointly infer all-sky $E$-mode and $B$-mode tomographic auto- and cross-power spectra from the masked sky, and potentially parity-violating $EB$-mode power spectra, up to a maximum multipole of $\ell_{\rm max}=2048$. We use Hamiltonian Monte Carlo sampling, inferring simultaneously the power spectra and denoised maps with a total of $\sim 16.8$ million free parameters. The main output and natural outcome is the set of samples of the posterior, which does not suffer from leakage of power from $E$ to $B$ unless reduced to point estimates. However, such point estimates of the power spectra, the mean and most likely maps, and their variances and covariances, can be computed if desired.
description: 18 pages, 16 figures - small changes in response to helpful comments from a referee
(2954) Stanley Bennett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation
Creators: name: Liebling, Michael
name: Staudt, David W.
name: Liu, Jiandong
name: Thorn, Kurt S.
name: Stainier, Didier Y.R.
name: Stuurman, Nico
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Over the course of development, the vertebrate heart undergoes a series of complex morphogenetic processes that transforms it from a simple myocardial epithelium to the complex 3D structure required for its function. One of these processes leads to the formation of trabeculae to optimize the internal structure of the ventricle for efficient conduction and contraction. Despite the important role of trabeculae in the development and physiology of the heart, little is known about their mechanism of formation. Using 3D time-lapse imaging of beating zebrafish hearts, we observed that the initiation of cardiac trabeculation can be divided into two processes. Before any myocardial cell bodies have entered the trabecular layer, cardiomyocytes extend protrusions that invade luminally along neighboring cell-cell junctions. These protrusions can interact within the trabecular layer to form new cell-cell contacts. Subsequently, cardiomyocytes constrict their abluminal surface, moving their cell bodies into the trabecular layer while elaborating more protrusions. We also examined the formation of these protrusions in trabeculation-deficient animals, including erbb2 mutants, tnnt2a morphants, which lack cardiac contractions and flow, and myh6 morphants, which lack atrial contraction and exhibit reduced flow. We found that, compared with cardiomyocytes in wild-type hearts, those in erbb2 mutants were less likely to form protrusions, those in tnnt2a morphants formed less stable protrusions, and those in myh6 morphants extended fewer protrusions per cell. Thus, through detailed 4D imaging of beating hearts, we have identified novel cellular behaviors underlying cardiac trabeculation.
Descargar [PDF] {EPUB} ZOLLINGER S ATLAS DE OPERACIONES QUIRURGICAS
Creators: name: Mcmahon
Publisher: name: Zenodo
Year: 2024

description: ZOLLINGER S ATLAS DE OPERACIONES QUIRURGICAS de R. - ELLISON, C. ZOLLINGER

Descargar eBook gratis ➡ Link

Ficha técnica

ZOLLINGER S ATLAS DE OPERACIONES QUIRURGICAS

R. - ELLISON, C. ZOLLINGER

Número de páginas: 584

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9789585426566

Editorial: AMOLCA

Año de edición: 2018

 

 

 

 

 

Los mejores libros de descarga gratuita pdf ZOLLINGER S ATLAS DE OPERACIONES QUIRURGICAS 9789585426566 en español

 

Overview

¡EL ATLAS QUIRÚRGICO CLÁSICO, MÁS COMPLETO QUE NUNCA! 1.710 ILUSTRACIONES DESTACADAS A TODO COLOR Por más de medio siglo, el Zollinger's Atlas de Operaciones Quirúrgicas, ha sido la referencia estándar de oro para aprender cómo realizar los procedimientos quirúrgicos más comunes que utilizan técnicas seguras y bien establecidas. La décima edición continúa con esta tradición de Excelencia. El atlas cubre los procedimientos gastrointestinales, hepatobiliares, pancreáticos, vasculares, ginecológicos y adicionales, que incluyen reparación de hernias, acceso vascular, procedimientos de mama, biopsia del ganglio linfático centinela, tiroidectomía y mucho más. Las ilustraciones en este atlas son probadas y han resistido la prueba del tiempo. Le permiten visualizar tanto la anatomía como el procedimiento quirúrgico, lo que hace al libro de gran utilidad para aprender los pasos de un procedimiento en particular. La décima edición del Zollinger's Atlas de Operaciones Quirúrgicas se expande en el contexto para incluir diecinueve (19) nuevas operaciones. Cada capítulo contiene hermosos dibujos lineales con colores destacados que representan acciones importantes que usted debe considerar mientras realiza la operación. Cada capítulo también incluye consistentemente una cobertura de: - Indicaciones - Preparación preoperatoria - Anestesia - Posición - Preparación operatoria - Incisión y exposición - Procedimiento - Cierre - Cuidado posoperatorio Autores E. Christopher Ellison Decano interino y, distinguido y profesor de cirugía enseñanzas de Robert M. Zollinger y profesor distinguido de The Ohio State University College of Medicine y Wexner Medical Center - Columbus, Ohio, EUA Robert M. Zollinger Profesor emérito, departamento de cirugía, Case Western Reserve University School of Medicine y University Hospitals Profesor clínico de cirugía, University of Arizona College of Medicine Ex-instructor en cirugía, Harvard Medical School y the Peter Bent Brigham Hospital, Tuscon, Arizona, EUA
Proteomic profiling of cardiac tissue by isolation of nuclei tagged in specific cell types (INTACT)
Creators: name: Greco, Todd M.
name: Chung, Mei I.
name: Conlon, Frank L.
name: Amin, Nirav M.
name: Kuchenbrod, Lauren M.
name: Cristea, Ileana M.
name: Wallingford, John B.
name: Rigney, Maggie M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The proper dissection of the molecular mechanisms governing the specification and differentiation of specific cell types requires isolation of pure cell populations from heterogeneous tissues and whole organisms. Here, we describe a method for purification of nuclei from defined cell or tissue types in vertebrate embryos using INTACT (isolation of nuclei tagged in specific cell types). This method, previously developed in plants, flies and worms, utilizes in vivo tagging of the nuclear envelope with biotin and the subsequent affinity purification of the labeled nuclei. In this study we successfully purified nuclei of cardiac and skeletal muscle from Xenopus using this strategy. We went on to demonstrate the utility of this approach by coupling the INTACT approach with liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic methodologies to profile proteins expressed in the nuclei of developing hearts. From these studies we have identified the Xenopus orthologs of 12 human proteins encoded by genes, which when mutated in human lead to congenital heart disease. Thus, by combining these technologies we are able to identify tissue-specific proteins that are expressed and required for normal vertebrate organ development.
Supplementary Methods: Hydrodynamic Modeling from Physical trade-offs shape the evolution of buoyancy control in sharks.
Creators: name: Gleiss, Adrian C.
name: Potvin, Jean
name: Goldbogen, Jeremy A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Buoyancy control is a fundamental aspect of aquatic life that has major implications for locomotor performance and ecological niche. Unlike terrestrial animals, the densities of aquatic animals are similar to the supporting fluid, thus even small changes in body density may have profound effects on locomotion. Here, we analysed the body composition (lipid versus lean tissue) of 32 shark species to study the evolution of buoyancy. Our comparative phylogenetic analyses indicate that although lean tissue displays minor positive allometry, liver volume exhibits pronounced positive allometry, suggesting that larger sharks evolved bulkier body compositions by adding lipid tissue to lean tissue rather than substituting lean for lipid tissue, particularly in the liver. We revealed a continuum of buoyancy control strategies that ranged from more buoyant sharks with larger livers in deeper ecosystems to relatively denser sharks with small livers in epipelagic habitats. Across this eco-morphological spectrum, our hydrodynamic modelling suggests that neutral buoyancy yields lower drag and more efficient steady swimming, whereas negative buoyancy may be more efficient during accelerated movements. The evolution of buoyancy control in sharks suggests that ecological and physiological factors mediate the selective pressures acting on these traits along two major gradients, body size and habitat depth.
Universal thermodynamics in different gravity theories: Modified entropy on the horizons
Creators: name: Mitra, Saugata
name: Saha, Subhajit
name: Chakraborty, Subenoy
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The paper deals with universal thermodynamics for FRW model of the universe bounded by apparent (or event) horizon. Assuming Hawking temperature on the horizon, the unified first law is examined on the horizon for different gravity theories. The results show that equilibrium configuration is preserved with a modification to Bekenstein entropy on the horizon.
(2956) Joseph Schofield
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
[PDF] Estación Damasco by David McCloskey, Jofre Homedes Beutnagel
Creators: name: Bratten
Publisher: name: Zenodo
Year: 2024

description: Estación Damasco by David McCloskey, Jofre Homedes Beutnagel

 

 

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Estación Damasco

David McCloskey, Jofre Homedes Beutnagel

Page: 560

Format: pdf, ePub, mobi, fb2

ISBN: 9788419851123

Publisher: SALAMANDRA

 

Free online download of ebooks Estación Damasco PDF by David McCloskey, Jofre Homedes Beutnagel 9788419851123 English version

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A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella
Creators: name: Zhang, Ling
name: Tang, Waixing
name: Teves, Maria E.
name: Peterson, Darrell L.
name: Zhang, Zhibing
name: Li, Wei
name: Zhang, Zhengang
name: Strauss, Jerome F.
name: Li, Hongfei
name: Williams, David C.
name: Archer, Kellie J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A key event in the process of spermiogenesis is the formation of the flagella, which enables sperm to reach eggs for fertilization. Yeast two-hybrid studies revealed that meiosis-expressed gene 1 (MEIG1) and Parkin co-regulated gene (PACRG) interact, and that sperm-associated antigen 16, which encodes an axoneme central apparatus protein, is also a binding partner of MEIG1. In spermatocytes of wild-type mice, MEIG1 is expressed in the whole germ cell bodies, but the protein migrates to the manchette, a unique structure at the base of elongating spermatid that directs formation of the flagella. In the elongating spermatids of wild-type mice, PACRG colocalizes with α-tubulin, a marker for the manchette, whereas this localization was not changed in the few remaining elongating spermatids of Meig1-deficient mice. In addition, MEIG1 no longer localizes to the manchette in the remaining elongating spermatids of Pacrg-deficient mice, indicating that PACRG recruits MEIG1 to the manchette. PACRG is not stable in mammalian cells, but can be stabilized by MEIG1 or by inhibition of proteasome function. SPAG16L is present in the spermatocyte cytoplasm of wild-type mice, and in the manchette of elongating spermatids, but in the Meig1 or Pacrg-deficient mice, SPAG16L no longer localizes to the manchette. By contrast, MEIG1 and PACRG are still present in the manchette of Spag16L-deficient mice, indicating that SPAG16L is a downstream partner of these two proteins. Together, our studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella.
[download pdf] My Alcoholic Escape from Reality by Nagata Kabi
Creators: name: Lunsford
Publisher: name: Zenodo
Year: 2024

description: My Alcoholic Escape from Reality by Nagata Kabi

 

 

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My Alcoholic Escape from Reality

Nagata Kabi

Page: 136

Format: pdf, ePub, mobi, fb2

ISBN: 9781645059998

Publisher: Seven Seas Entertainment LLC

 

Free spanish audiobook downloads My Alcoholic Escape from Reality FB2 CHM ePub

Overview

An emotional new diary comic from the award-winning creator of My Lesbian Experience with Loneliness and My Solo Exchange Diary. Nagata Kabi’s downward spiral is getting out of control, and she can’t stop drinking to soothe the ache of reality. After suffering from unbearable stomach pains, she goes to a clinic, where she is diagnosed with pancreatitis—and is immediately hospitalized. A new chapter unfolds in Nagata Kabi’s life as she struggles to find her way back to reality and manga creation in the wake of her breakdown.
(2953) Annie Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
One-loop hexagon integral to higher orders in the dimensional regulator
Creators: name: Henn, Johannes M.
name: Matijašić, Antonela
name: Miczajka, Julian
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The state-of-the-art in current two-loop QCD amplitude calculations is at five-particle scattering. Computing two-loop six-particle processes requires knowledge of the corresponding one-loop amplitudes to higher orders in the dimensional regulator. In this paper we compute analytically the one-loop hexagon integral via differential equations. In particular we identify its function alphabet for general $D$-dimensional external states. We also provide integral representations for all one-loop integrals up to weight four. With this, the one-loop integral basis is ready for two-loop amplitude applications. We also study in detail the difference between the conventional dimensional regularization and the four-dimensional helicity scheme at the level of the master integrals and their function space.
description: 34 pages
Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice
Creators: name: Williams, Scott E.
name: Oyarzabal, Esteban A.
name: Li, Shiyi
name: Garcia, Idoia
name: O’Neill, Sean
name: Crowther, Andrew J.
name: Gershon, Timothy R.
name: Stewart, Alyssa
name: Liu, Hedi
name: Shih, Yen Yu Ian
name: Merrill, Joseph R.
name: Lough, Kendall J.
name: Veleta, Katherine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Alterations in genes that regulate brain size may contribute to both microcephaly and brain tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor. Cerebellar granule neuron progenitors (CGNPs) express Aspm when maintained in a proliferative state by sonic hedgehog (Shh) signaling, and Aspm is expressed in Shh-driven medulloblastoma in mice. Genetic deletion of Aspm reduces cerebellar growth, while paradoxically increasing the mitotic rate of CGNPs. Aspm-deficient CGNPs show impaired mitotic progression, altered patterns of division orientation and differentiation, and increased DNA damage, which causes progenitor attrition through apoptosis. Deletion of Aspm in mice with Smo-induced medulloblastoma reduces tumor growth and increases DNA damage. Co-deletion of Aspm and either of the apoptosis regulators Bax or Trp53 (also known as p53) rescues the survival of neural progenitors and reduces the growth restriction imposed by Aspm deletion. Our data show that Aspm functions to regulate mitosis and to mitigate DNA damage during CGNP cell division, causes microcephaly through progenitor apoptosis when mutated, and sustains tumor growth in medulloblastoma.