cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis, identification and evaluation of molecular docking and experimental anti-cancer and antioxidant activity of new spiro four membered ring derivatives bearing 5-nitro isatin
Creators: name: Rasheed, Hala Ayad Mohamed
name: Al-Majidi, Suaad M. H.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer

description: Spiro-5-nitro isatino aza-β-lactams were produced by a [2 + 2] cycloaddition of 5-nitro isatin Schiff bases [1–5] with different aromatic isocyanate and thioisocyanate. 1HNMR and 13CNMR as well as FTIR spectroscopies, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin aza- β-lactams interest to us due to their potential antioxidant and anticancer properties. The MTT assay was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines. From result data, compound 14 displayed IC50 values that were lower than those of the clinically used anticancer drug tamoxifen toward MCF-7 cells after 24 h while compound 9 after 48 h synthesized compounds [6–20] were evaluated for against antioxidant activity by using DPPH assay. In molecular docking, Promising compounds were used to reveal potential cytotoxic activity mechanisms.
Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Down-regulating VCAM-1 and N-cadherin
Creators: name: Lee, Jeong-Hee
Publisher: name: APJCP
Year: 2016
Subjects: Breast cancer cells , morin , metastasis , adhesion , VCAM-1 , N-cadherinn , downregulation

description: Asian Pacific Journal of Cancer Prevention, 17, 7
title: Coprime and Nested Array Processing of the Elba Island Sonar Data Set
Creators: name: Chavali, Vaibhav
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Sparse arrays
subject: Coprime and nested arrays
subject: Beamforming
subject: Array signal processing
subject: Spectrum analysis
subject: Passive sonar

description: Sensor arrays can provide estimates of the spatial spectrum associated with propagating waves in a variety of environments, e.g., acoustic waves in the ocean. Vaidyanathan and Pal [IEEE Trans. Sig. Proc., 2010, 2011] describe coprime and nested array geometries that provide significant sensor savings when compared to densely populated Uniform Linear Arrays (ULAs). Coprime Sensor Arrays (CSAs) and Nested Arrays (NAs) consist of two interleaved subarrays with different sample spacings. To reduce the number of sensors, at least one of the subarrays is undersampled. There are several approaches to estimating the spatial power spectrum given a sparse set of CSA or NA measurements. The classical approach is to implement a multiplicative processor. Multiplication of the beamformed outputs of two undersampled subarrays eliminates the ambiguity due to aliasing, but requires temporal averaging to mitigate cross terms. This approach relies on the assumption that signals arriving from different directions are uncorrelated. Recently Liu and Buck proposed an alternative that is not restricted to uncorrelated signals [IEEE SAM, 2016]. Their min processor uses the minimum of the two subarray outputs as the spectral estimate. The goal of this thesis is to design and implement CSA and NA processing for data from an underwater vertical line array deployed near Elba Island. Building on the work of Adhikari et al. [EURASIP J. Advances Sig. Proc., 2014], this thesis shows that CSA and NA designs for the Elba experiment can attain beampatterns comparable to a fully populated ULA using 33% fewer sensors. As noted above, one drawback of the standard multiplicative processing approach is the need for time averaging to reduce cross terms. Prior work has not quantified the amount of averaging required. This thesis analyzes cross terms using a Gaussian signal model and shows that they decay at a rate of 5 dB per decade of snapshots averaged. Finally, this thesis implements CSA and NA multiplicative and min processing for the Elba data set. Compared to the conventional spectrum obtained with the ULA, the multiplicative CSA and NA spectra for the Elba data contain endfire interference due to cross terms associated with coherent mode arrivals. Liu and Buck's min processor applied to the NA design performs the best for the Elba data set.
New steroidal saponins from the roots of Paris verticillata
Creators: name: Liu, Yang
name: Tang, Na
name: Qian, Xiao-Ying
name: Li, Tian-Yi
name: Zhang, Qian
name: Qiu, Peng-Cheng
name: Tang, Hai-Feng
name: Lu, Yun-Yang
name: Zhang, Bang-Le
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Four new polyhydroxylated steroidal saponins, parisverticillatosides A-D (1–4), together with four known spirostanol saponins (5–8) were isolated from the roots of Paris verticillata. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1–4 extended the diversity and complexity of this spirostanol saponin family. The saponins 5 and 6 exhibited cytotoxicities against two human glioma cell lines.
Anti-Tumor and Immunoregulatory Effects of Fermented Papaya Preparation (FPP: SAIDO-PS501)
Creators: name: Shinki Murakami
Publisher: name: APJCP
Year: 2016
Subjects: Fermented papaya preparation , anti-tumorigenesis , immunoregulatory function , interferon , regulatory

description: Asian Pacific Journal of Cancer Prevention, 17, 7
title: Memo: C. Everett Wallace to Samuel R. Pierce, Jr., "Woodlands Project - Affirmative Action Problems," November 17, 1981
Creators: name: Wallace, C. Everett
Publisher: name: George Mason University
Year: 2006

description: Textual: Memo, copy; 11” x 8.5” (27.9 cm x 21.6 cm)
description: Memo from C. Everett Wallace, General Deputy Assistant Secretary for Fair Housing and Equal Opportunity, to Samuel R. Pierce, Jr., Secretary of the Department of Housing and Urban Development, with the subject line "Woodlands Project - Affirmative Action Problems" dated November 17, 1981. Wallace discusses problems with the Affirmative Action Plan developed for the Woodlands Project, twenty miles north of Houston, Texas. Planned Community Archives Collection, 484.03
El as de bastos: Digital Edition
Creators: name: Jacsont Pauline
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool eScriptorium (ALTO-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Does the Presence of Primary Circulating Prostate Cells Imply the Presence of Agressive Prostate Cancer with Early Biochemical Failure: a Comparison with the Walz Nomogram
Creators: name: Murray, Nigel P
Publisher: name: APJCP
Year: 2016
Subjects: Prostate cancer , biochemical failure , circulating prostate cells , Walz nomogram

description: Asian Pacific Journal of Cancer Prevention, 17, 7
Mao shi gu xun zhuan ding ben : san shi juan [volume 07]
毛詩故訓傳定本 : 三十卷 [第七冊]
Creators: name: Duan, Yucai, 1735-1815
name: 段玉裁, 1735-1815
Publisher: name: [China] : [publisher not identified]
Year: 2017

description: Wood-block printing, on double leaves, East Asian binding.
Edition: [Ke ben]
Chemical constituents from Trillium camschatcense
Creators: name: Xie, Jianwei
name: Wang, Kunjun
name: Gao, Xiaoxu
name: Wang, Anhua
name: Hu, Gaosheng
name: Yan, Ting
name: Jia, Jingming
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Two undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J (1) and 21-deoxyepitrillenoside C (2), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B (3) along with four known steroidal saponins (4–7), were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium camschatcense. The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds 1,3 and 4 had potential cytotoxic activity against MCF-7, with IC50 values 86.38 ± 2.59 μM, 56.20 ± 1.57 μM and 45.70 ± 0.63 μM.
Methoxylated bibenzyls and isoflavones from Baphia massaiensis Taub
Creators: name: Kgakatsi, Nayang A.
name: Majinda, Runner R. T.
name: Masesane, Ishmael B.
name: Gobe, Irene
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Chemical investigation of the stem bark of Baphia massaiensis Taub. led to the isolation of two new natural compounds named 3-hydroxy-2,5,2′-trimethoxybibenzyl (1) and 2′-hydroxy-2,3,5,6-tetramethoxybibenzyl (2), the latter has been previously reported as a synthetic compound, together with twelve known compounds 3–14. The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature. Known bibenzyls 3–5, bauhinoxepin J (6), and isoflavones 7–10 and 12–14, were reported from genus Baphia for the first time. The isolated compounds were evaluated for their antibacterial activities in-vitro against Staphylococcus aureus and Escherichia coli. The bioactivity evaluation revealed that bibenzyls 1 and 2 showed weak inhibitory activity with MIC values of 1000 µg/mL against S. aureus and bauhinoxepin J (6) showed moderate inhibitory activity with MIC value of 63 µg/mL against S. aureus.
Mao shi gu xun zhuan ding ben : san shi juan [volume 03]
毛詩故訓傳定本 : 三十卷 [第三冊]
Creators: name: Duan, Yucai, 1735-1815
name: 段玉裁, 1735-1815
Publisher: name: [China] : [publisher not identified]
Year: 2017

description: Wood-block printing, on double leaves, East Asian binding.
Edition: [Ke ben]
title: Plan: Dan Coleman Associates, "Technical College Reston, Virginia," July 1, 1968
Creators: name: Associates, Dan Coleman
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Reston (Va.)

description: Textual: plan, original; 13.5” x 9.5” (34.3 cm x 24.1 cm)
description: Plan by Dan Coleman Associates entitled "Technical College Reston, Virginia" dated July 1, 1968. This is the completed plan discussing a viability of locating a college in Reston, Virginia. The report details the potential student population, transportation and location for the campus. The excerpt given here is the introduction and title page of the report. Planned Community Archives Collection, rm03.04
Additional file 1 of Outbreak detection in Harar town and Kersa district, Ethiopia using phylogenetic analysis and source attribution
Creators: name: Thystrup, Cecilie
name: Hald, Tine
name: Belina, Dinaol
name: Gobena, Tesfaye
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
Prevalence of Abnormal Cervical Cytology in HIV-Negative Women Participating in a Cervical Cancer Screening Program in Calmette Hospital, Cambodia
Creators: name: Monirath Hav
Publisher: name: APJCP
Year: 2016
Subjects: Cambodia , cervical cancer screening , prevalence of abnormal cervical cytology

description: Asian Pacific Journal of Cancer Prevention, 17, 7
title: Spatial and Temporal Scheduling of Clock Arrival Times for IR Hot-Spot Mitigation, Reformulation of Peak Current Reduction & Physical Design Automation Tool
Creators: name: Gunna, Bhoopal
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Clock-tree synthesis
subject: IR-drop
subject: Power delivery network
subject: Peak current

description: One of the major reason for chip failures is on chip variability. In order to prevent failures due to on chip variability, the variability need to be margined in physical design by providing voltage guard band. One of the major reasons of variability is dynamic IR drop. To prevent the timing failures due to large IR drop, big margin is provided as voltage gaur band. So by reducing IR drop the timing failures can be avoided and this gives option for reducing the voltage gaur band margin. In this thesis we propose a technique to reduce the IR drop by temporal scheduling of clock arrival times for IR Hot-Spot mitigation. In this technique we utilize the available slack and scheduling useful skew we distribute the switching of cells within the timing window. Previous work done for reducing the IR-drop was focused on reducing the overall peak current but we breakdown the problem into many smaller problems of local IR-hotspots. And based on location of the cells we group them based on minimum resistive region and change the clock arrival time of the flip flops for reducing the intensity of individual hot spots. Application of the proposed solution to a selected number of IWLS benchmarks reduces the peak IR-drop by ~35%, and peak current by ~37%. We have published papers on this work in conference ISLPED [1]and ISVLSI [2]. Complete Physical design process involves various tools like Design compiler, Primetime, ICC and needs many scripts to be implemented and executed. And complete Physical design process is time consuming and based on the size of the design. To automate the physical design process across all tools used a tool was implemented based using GNU make. Using this Physical design automation tool all the physical design steps like Synthesis, Floor-planning, Placement, Clock Tree Synthesis, Routing and STA analysis was automated.
A new flavonoid from Epimedium brevicornu Maxim
Creators: name: Jiang, Juan
name: Jiang, Bao-Guo
name: Liu, Bing
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Virology

description: Epimedium brevicornu Maxim (E. brevicornu) is a plant of Epimedium L. in Berberidaceae, which is widely distributed and has high medicinal value and many important clinical applications. In this experiment, a novel flavonoid compound (1) was isolated and identified the chemical structure from E. brevicornu. The extract of E. brevicornu was performed on normal silica column chromatography, ODS silica column chromatography, Sephadex LH-20 column chromatography and RP-HPLC system to be isolated and purified and obtained 1. The HR-ESI-MS and NMR spectrometer were used to measure the accuracy molecular weights and determine the chemical structure of 1. In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.
A new monocyclic monoterpene derivative from volva of Phallus dongsun
Creators: name: Qian, Shihao
name: Wang, Guangdi
name: Lu, Meiling
name: Zhang, Xian
name: Wen, Tingchi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: A new monoterpene derivative namely dongsunol A (1) and sixteen known compounds (2–17) were isolated from the volva of Phallus dongsun. All compounds were isolated from this fungus for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance (NMR), HRESIMS spectral data, and electronic circular dichroism (ECD). The new monoterpene derivative (1) exhibited antibacterial activity with a MIC of 200 μg/mL. Other compounds have inhibitory effects on Staphylococcus aureus and Pseudomonas aeruginosa, while have displayed moderate NO inhibitory activity and antineoplastic activity on SMMC-7721 and SW480 in vitro.
Sphaeranthone A, a new carvotacetone from the leaves of Sphaeranthus africanus
Creators: name: Nguyen, Ngoc-Hong
name: Duong, Thuc-Huy
name: Tran, Thi-Minh-Dinh
name: Le, Hoang-Khai
name: Thach, Ut Dong
name: Nguyen, Khanh-Duy Kieu
name: Nguyen, Huy Truong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: A new carvotacetone sphaeranthone A and four known compounds 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (2), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (3), chrysosplenol D (4), and 3-O-methylquercetin (5) were isolated from leaves of Sphaeranthus africanus growing in Vietnam. Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. Compounds 1-3 were evaluated for the alpha-glucosidase inhibition. They showed moderate activity with IC50 values of 103 ± 1.7, 146.8 ± 2.5, 49 ± 0.8 µg/mL, respectively.
New benzoquinone pigments from the hydnoid fungus Sarcodontia setosa and their biosynthetic relationship
Creators: name: Whaley, Andrei K.
name: Ponkratova, Anastasiia O.
name: Orlova, Anastasia A.
name: Volobuev, Sergey V.
name: Shakhova, Natalia V.
name: Serebryakov, Evgeny B.
name: Smirnov, Sergey N.
name: Pustovit, Natalia V.
name: Kraeva, Liudmila A.
name: Luzhanin, Vladimir G.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Chemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivatives – setosic acid (1) and 7,8-dehydrohomosarcodontic acid (2) along with three known benzoquinone pigments – sarcodontic acid (3), 4,5-dehydrosarcodontic acid (4) and dihydrosarcodontic acid (5). The structures were elucidated using spectroscopic methods (UV, NMR and HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial activity screening of compounds 1–5 against ESKAPE bacterial strains in vitro with zones of inhibition was performed and MIC values were established for the most active compounds (3 and 5).
Er ya xin yi : er shi juan [volume 04]
爾雅新義 : 二十卷 [第四冊]
Creators: name: Lu, Dian, 1042-1102
name: 陸佃, 1042-1102
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Edition: [Chao ben]
Two pairs of new isobenzofuranone enantiomers from a soil-derived fungus Penicillium canescens DWS225
Creators: name: Wang, Jing
name: Wu, Xiao-Qian
name: Mo, Ji-Song
name: Tan, Yu-Fen
name: Long, Hong-Ping
name: Zhou, Si-Qian
name: Liu, Shao
name: Li, Jing
name: Wang, Wen-Xuan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Two pairs of new isobenzofuranone derivative enantiomers, (±)-penicifurans E (1) and (±)-penicifurans F (2), together with four know compounds (3–6) were isolated from the solid fermentation of Penicillium canescens DWS225. The structures of these enantiomers were elucidated by extensive NMR spectroscopic data, and their absolute configurations were assigned by the experimental and calculated ECD data. The neuroprotective effects of all the isolates against oxygen-glucose deprivation/reperfusion injury in pheochromocytoma-12 cells (PC12) were investigated.
title: Synthesis of Leukotriene A4 Hydrolase (LTA4H) Aminopeptidase (AP) Modulators Using Cross-Coupling Reactions and Synthesis of Oxetanyl Peptidomimetics
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: The leukotriene A4 hydrolase (LTA4H) enzyme is a potential biological target for treatment of inflammatory diseases. Most drug discovery efforts have focused on inhibition of the epoxide hydrolase (EH) activity but this strategy has failed to show promising results in human clinical trials. Activation of LTA4H’s aminopeptidase (AP) activity by 4-methoxydiphenylmethane (4MDM) was shown to resolve inflammation in chronic obstructive pulmonary disease (COPD) mouse models, providing an alternative strategy for treatment of inflammatory diseases. The bulk of this work focuses on the synthesis and enzyme kinetic evaluation of novel LTA4H AP modulators. The goal was to find a superior activator of the AP activity of LTA4H compared to 4MDM. A smaller portion of this work is dedicated to the synthesis of oxetanyl peptidomimetics, which are an emerging class of peptidomimetics that have potential applications in drug discovery.
Supplementary document for Multi-target reconstruction strategy based on blind source separation of surface measurement signals in FMT - 6274488.pdf
Creators: name: Zhang, Lizhi
name: tao, Li
name: Kang, Dizhen
name: Zhang, diya
name: He, Xiaowei
name: Zhao, Yizhe
name: Wei, De
name: hongbo, Guo
name: Yu, Jingjing
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document presents the supplementary details to "Multi-target reconstruction strategy based on blind source separation of surface measurement signals in FMT"
title: Newspaper Column: A Master Executive Comes and Goes
Creators: name: Nicoson, William J.
Publisher: name: The Connection
Year: 1999
Subjects: subject: O'Neill, Robert J.
subject: Fairfax County (VA) Government
subject: National Academy of Public Administration (NAPA)

description: PDF file distilled from original WordPerfect document. Original size 11" x 8.5".
description: Robert J. O’Neill, Jr., arrived in August 1997 to become Fairfax County Executive, raising high hopes that he could do for Fairfax County what he did for Hampton, Virginia. There he is credited with “reinventing government” during 13 years of service as city manager -- a performance celebrated by expert commentators in Banishing Bureaucracy (1997) and winning him the prestigious National Public Service Award in 1996. Next month O’Neill will leave Fairfax County to become President of the National Academy of Public Administration, of which he was appointed a lifetime fellow in 1997. The nonpartisan,independent Academy chartered by Congress sponsors studies of government operations at alllevels but itself exercises no government functions and employs a staff too slim to trim. To escape the political winds of Fairfax County may be a relief for O’Neill, but those close to him wonder whether his executive talents will be wasted.
Comparing Recurrence and Complications After Laparoscopy and Laparotomy Surgery among Patients Suffering from Colorectal Cancer, Shiraz, Iran
Creators: name: Haleh Ghaem
Publisher: name: APJCP
Year: 2016
Subjects: Colorectal cancer , recurrence , complications , laparoscopy , laparotomy , Iran

description: Asian Pacific Journal of Cancer Prevention, 17, 7
Incidence and Management of Toxicity Associated with L-Asparaginase in the Treatment of ALL and NK/T-Cell Lymphoma: an Observational Study
Creators: name: Yeang, Shu Hui
Publisher: name: APJCP
Year: 2016
Subjects: L-Asparaginase , ALL - NK/T cell lymphoma , treatment , toxicity , hypersensitivity

description: Asian Pacific Journal of Cancer Prevention, 17, 7
title: Investigation into the Link between Object Perception and Neural Activity in the Human Brain Using ECoG Data
Creators: name: Stenberg, Sabrina
Publisher: name: George Mason University
Year: 2022
Subjects: subject: ECoG
subject: Neuroscience
subject: Human Brain

description: One area under investigation in the field of neuroscience is the link between object perception and neural activity in visual cortical areas of the human brain. By investigating the electrical potentials from the ventral temporal cortical surface in humans, the Stanford University study selected for this paper sought to collect sufficient information for spontaneous and near-instantaneous identification of a subject’s perceptual state. The brain signal data collection technique used by the researchers was electrocorticography (ECoG), using ECoG arrays placed on the subtemporal cortical surface of seven epilepsy patients. ECoG is an invasive electrogram method, requiring access to the surface of the brain, which can be applied to measure brain signals in response to specific stimuli. Using publicly available human ECoG recording data previously collected and made publicly available, this paper investigates visual object processing in the human brain. The data are taken from a study where seven epilepsy patients were shown house and face images in quick succession. We use those data and filter, process, and plot selected data to investigate the correct identification of the stimuli. We discovered that the incorrect stimuli matches are driven by variance in the human brain activity corresponding to the same set of stimuli. Better understanding of the visual processing capabilities of the human brain could lead to developments in machine learning, as well as generate recommendations for future data collection in human visual object processing.
title: Domestic Violence inside the Courtroom: The Role of the Judge in Protection from Abuse Order Hearings
Creators: name: Hvizdos, Aimee
Publisher: name: George Mason University
Year: 2015
Subjects: subject: Domestic violence
subject: Judge
subject: Pennsylvania
subject: California
subject: Women's rights
subject: Protection from abuse

description: This thesis describes the nationwide epidemic of domestic violence in the United States. The role that a judge takes in Protection from Abuse hearings and how the judge’s demeanor and authority play a vital role in the courtroom is examined as a contributing factor to the social issue of domestic violence. Research was conducted to explore the dynamic between the judge and the victim by using Federal and state legislation, as well as courtroom observations and extensive literature. In the process of researching and writing this thesis, the author conducted courtroom observations to analyze the behavior of two judges in the Commonwealth of Pennsylvania. This thesis is designed for the use of academics and domestic violence agencies to continue research on the development of legislation, regulations, and judge training programs.
Ancistrobrevinium A, the first N-methylated, cationic naphthylisoquinoline alkaloid, from the tropical liana Ancistrocladus abbreviatus (Ancistrocladaceae)
Creators: name: Tajuddeen, Nasir
name: Fayez, Shaimaa
name: Kushwaha, Prem Prakash
name: Feineis, Doris
name: Assi, Laurent Aké
name: Kumar, Shashank
name: Bringmann, Gerhard
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Ancistrobrevinium A (1) is the first N-methylated and non-hydrogenated, and thus cationic naphthylisoquinoline alkaloid. It was discovered in the root bark extract of the phytochemically productive West African liana Ancistrocladus abbreviatus (Ancistrocladaceae). Its constitution was elucidated by HR-ESI-MS and 1D and 2D NMR. Due to the steric hindrance in the proximity of the linkage between the naphthalene and isoquinoline parts, the biaryl axis is rotationally hindered. It thus constitutes a stable element of chirality – the only one in the new alkaloid since, different from most other naphthylisoquinoline alkaloids, it has no stereogenic centers. The axial configuration of 1 was assigned by electronic circular dichroism (ECD) investigations, which gave a positive couplet, indicating a ‘positive chirality’, here corresponding to a P-configuration. Ancistrobrevinium A (1) showed a weak cytotoxic activity against A549 lung cancer cells (IC50 = 50.6 μM).
title: Policy Watch: What Maliki's move means
Creators: name: Katz, Mark N.
Publisher: name: UPI.com (United Press International, Inc.)
Year: 2006
Subjects: subject: International affairs
subject: Iraq War, 2003-2010

description: © 2006 United Press International, Inc. All Rights Reserved. Deposited with permission from UPI.com.
description: Although he has dropped his "stay the course" slogan, President Bush has made clear that he intends to keep American forces in Iraq until they achieve "victory." He defines victory to be a peaceful, stable, self-governing Iraq that will cooperate with Iraqi Prime Minister Nouri al- Maliki's actions, though recent developments have shown that a victory of this sort may not be achievable.
Lanostane triterpenoids from artificially cultivated fruiting bodies of Ganoderma cf. mastoporum
Creators: name: Yangchum, Arunrat
name: Rachtawee, Pranee
name: Srichomthong, Kitlada
name: Choeyklin, Rattaket
name: Boonpratuang, Thitiya
name: Thongpanchang, Chawanee
name: Isaka, Masahiko
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: In the quest for bioactive compounds from Ganoderma, artificially cultivated fruiting bodies of Ganoderma cf. mastoporum, strain TBRC-BCC 47851 were chemically investigated. The study led to the isolation of three undescribed lanostane triterpenoids (1–3) together with twelve known compounds. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The new compounds were inactive in the antimalarial and antitubercular activity assays.
Er ya xin yi : er shi juan [volume 03]
爾雅新義 : 二十卷 [第三冊]
Creators: name: Lu, Dian, 1042-1102
name: 陸佃, 1042-1102
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Edition: [Chao ben]
Er ya xin yi : er shi juan [volume 02]
爾雅新義 : 二十卷 [第二冊]
Creators: name: Lu, Dian, 1042-1102
name: 陸佃, 1042-1102
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Edition: [Chao ben]
title: Holy Counter-Revolution on Trial: The Russian Orthodox Church and the Bolshevik State, 1918-1921
Creators: name: Dockham, Carol J.
Publisher: name: George Mason University
Year: 2009
Subjects: subject: Russian Orthodox Church
subject: Counter-revolution
subject: Trial
subject: Bolshevik
subject: Revolutionary tribunal

description: The first “official” assault of the Bolsheviks against religion was carried out against the institution of the Russian Orthodox Church from 1918-1921, during the civil war period in Soviet Russia. The assault was two-pronged, consisting of legal measures and a propaganda campaign against the Church and its leaders, consisting of clergy and laymen, who were collectively termed as “churchmen.” Of the legal measures, the most important was the decree on the separation of the Church from the State, which deprived the institutional Church of its former privileges, income, and property. When the Church leaders reacted protested the violence and bloodshed caused by the revolutionaries as well as the new conditions imposed by the decree on the separation of the Church from the State, the Bolsheviks claimed they had declared a “holy war” against the regime and had instigated a “holy counter-revolution” to overthrow it. The Bolsheviks sought to discredit the Church leaders through a slanderous propaganda campaign in newspapers that denounced them as monarchists and reactionaries. In early 1918, churchmen began appearing before revolutionary tribunals, which had been established in November 1917 to combat counter-revolutionary activities. The tribunals existed alongside the All-Russian Extraordinary Commission, or Cheka, which shot thousands of people, including churchmen, on an extrajudicial basis without trial. The revolutionary tribunals received the right to use the death penalty in June 1918; however, their primary purpose with regard to the Church was not to kill off churchmen, but to discredit them in the eyes of the people. Although exact statistics were not kept during as to the total number of trials involving churchmen, the chief accuser of the tribunals, Nikolai Vasilievich Krylenko, declared in January 1920 that such trials had been heard in nearly every revolutionary tribunal of Soviet Russia. The trials of the churchmen were considered by Soviet scholars to have been instrumental in breaking the back of the Church counter-revolution and contributing to the break-away of the masses from religious belief. While the Church was undeniably weakened as an institution during the civil war years, this was probably due more to other factors, with the trials playing only a minor role. The trials played a slightly more important role in conveying the Bolshevik views on religion to the masses, which resulted in a reduction of overt religious displays in public life. They also helped changed the behavior of the churchmen, who never again challenged the authority of the Soviet State.
Hipposponols A and B, two new 9, 11-secosterols from the marine sponge Hippospongia lachne de Laubenfels
Creators: name: Ding, Ya-Fang
name: Liu, Li-Yun
name: Tang, Jie
name: Fan, Dong-Xue
name: Ji, Yuan-Yuan
name: Lin, Hou-Wen
name: Wang, Jie
name: Hong, Li-Li
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Two new 9,11-secosterols, hipposponols A (1) and B (2), together with five known analogues, aplidiasterol B (3), (3β,5α,6β)-3,5,6-triol-cholest-7-ene (4), (3β,5α,6β,22E)-3,5,6-triol-ergosta-7,22-diene (5), and one pair of inseparable C-24 epimers of (3β,5α,6β,22E)-3,5,6-triol-stigmasta-7,22-diene (6/7), were isolated from the marine sponge Hippospongia lachne de Laubenfels. The structures of isolated compounds were extensively elucidated based on HRESIMS and NMR data. Compounds 2 − 5 showed cytotoxicity against PC9 cells with IC50 values ranging from 34.1 ± 0.9 to 38.9 ± 1.0 µM and compound 4 displayed cytotoxicity against MCF-7 cells with IC50 value of 39.0 ± 0.4 µM.
Reassignment of NMR spectroscopic data of oleana-9(11),12-diene-3β-ol isolated from Jeffreycia zeylanica and its wound healing potential in terms of cell migration and proangiogenic activity1
Creators: name: Samarasinghe, W. M. Priyantha
name: Gunaherath, G. M. Kamal B.
name: Ranasinghe, Chandani
name: Jayawardana, K. Hector
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Jeffreycia zeylanica (Asteraceae), a plant endemic to Sri Lanka, is used for the treatment of wounds. The scratch wound assay (SWA) guided fractionation of hexanes extract of J. zeylanica led to the isolation of oleana-9(11),12-diene-3β-ol (1) which showed enhanced cell migration in SWA and significant proangiogenic response in chorioallantoic membrane (CAM) assay. Since the reported 1H NMR assignments of 1 were incomplete, and some 13C NMR assignments were inconsistent with our observations, reassignment of NMR spectroscopic data of 1 was carried out. Herein we report unambiguous assignment of NMR data of 1 based on 1D and 2D NMR spectra. This is the first report of 1 in J. zeylanica.
title: Travelers of the Great Spaces
Creators: name: Seward, Spencer
Publisher: name: George Mason University
Year: 2014
Subjects: subject: Fiction
subject: Novel
subject: American
subject: Tab

description: This thesis is the first section of a novel-in-progress, and follows the machinations of the Governor of X and his assistant as they try to deal with the burgeoning crisis of a plague as it spreads through the city.
In silico study of novel marine alkaloid jolynamine and other marine compounds via molecular docking, MM-GBSA binding energy prediction, ADMET evaluation, and molecular dynamics simulation
Creators: name: Gul, Sana
name: Khan, Abdul Majeed
name: Ali, Syed Tahir
name: Rizwan, Samra
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: In this research article bacterial (Escherichia coli and Pseudomonas aeruginosa) and fungal (Aspergillus niger and Candida albicans) enzymes are used for molecular docking of novel marine alkaloid jolynamine (10) and six marine natural compounds. Till date, no computational studies have been reported. In addition, MM/GBSA analysis is conducted for estimation of binding free energies. Furthermore, ADMET physicochemical properties were explored to understand the drug likeness property of compounds. In silico results showed that jolynamine (10) has more negative predicted binding energy among natural products. The ADMET profile of all compounds accepted the Lipinski rule and jolynamine also showed negative MM/GBSA binding free energy. Moreover, MD simulation was subjected to check structure stability. The outcomes of MD simulation of jolynamine (10) showed structure stability over 50 ns simulation. This study will hopefully facilitate the finding of other natural products and expedite the drug discovery process to screen drug like chemical compounds.
Parmoferone A, a new depsidone from the lichen Parmotrema cristiferum
Creators: name: Duong, Thuc-Huy
name: An, Tran Nguyen Minh
name: Le, Thi-Kim-Dung
name: Tran, Thi-Minh-Dinh
name: Nguyen, Huy Truong
name: Nguyen, Thi Hong Anh
name: Nguyen, Ngoc-Hong
name: Sichaem, Jirapast
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: A new depsidone, parmoferone A (1), together with three known compounds, parmosidone K (2), albifolione (3), and 4-chloroorcinol (4) were isolated from the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae). The structures of isolated compounds were identified from its spectroscopic data and by comparison with the literature. Compounds 1-4 were evaluated for alpha-glucosidase inhibition. Compound 1 was determined to be a potent non-competitive inhibitor against alpha-glucosidase with an IC50 value of 18.1 μM.
Characterization of polyphenols in the methanol leaf extract of Bathysa gymnocarpa (Rubiaceae) by HPLC-DAD-ESI-MS/MS
Creators: name: Araujo, Ariel M.
name: Cruz, Lucas M.
name: Gomes, Mário
name: Gallo, Blanca
name: Valente, Ligia M. M.
name: Berrueta, Luis A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The species Bathysa gymnocarpa K.Schum is a tree belonging to the Rubiaceae family, endemic in Brazil. So far, there are reports neither of phytochemical work nor of biological evaluation of it. The analysis by High Performance Liquid Chromatography coupled to a Diode Array Detector and a tandem Mass Spectrometer with an Electrospray Ionization source (HPLC‐DAD‐ESI‐MS/MS) of its crude extract allowed to characterize in a complex mixture, without isolation, fourteen compounds, being two as cinnamic acid derivatives, and the others as mono-, di- and triglycosilated derivatives of the flavonols quercetin and kaempferol. These compounds are reported for the first time in Bathysa spp.
Additional file 1 of Characterization of a conductive hydrogel@Carbon fibers electrode as a novel intraneural interface
Creators: name: Giannotti, Alice
name: Santanché, Ranieri
name: Zinno, Ciro
name: Carpaneto, Jacopo
name: Micera, Silvestro
name: Riva, Eugenio Redolfi
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Neuroscience
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Computational Biology

description: Supplementary Material 1.
title: Initial Study on Handling Constrained Optimization Problems in Learnable Evolution Model
Creators: name: Wojtusiak, Janusz
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Concept learning
subject: Induction
subject: Constrained optimization

description: Learnable Evolution Model (LEM) is an evolutionary computation methodology that applies hypothesis formulation and instantiation to create new individuals. Initial study has shown that LEM significantly outperforms standard evolutionary computation methods in terms of evolution length on selected benchmark optimization problems. This paper presents initial results from handling constrained optimization problems in LEM. Constraints are classified as instantiable, which can be handled directly during instantiation process, and general, which cannot be directly instantiated. The latter can be handled by applying three different methods presented in this paper.
Isolation and identification of antioxidant constituents from the flowers of Salvia miltiorrhiza
Creators: name: Jiang, Xue
name: Chi, Jun
name: Feng, Qingmei
name: Wu, Hong
name: Wang, Zhimin
name: Dai, Liping
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Virology

description: A new salvianolic acid derivative, (7′E)-(7S, 8S)-salvianolic acid V (1), together with four previously described compounds (2-5) were obtained from the n-butanol fraction of Salvia miltiorrhiza flowers. Their structures were established by a series of spectroscopic methods, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) calculation. Salvianolic acids (1) and phenolic acids (2-4) showed stronger DPPH free radical scavenging abilities and certain protective effects against H2O2-induced human skin fibroblast (HSF) cells oxidative damage, in which compound 1 (IC50 7.12 μM) possessed more noticeable free radical scavenging activity than the positive control vitamin C (IC50 14.98 μM).
Er ya xin yi : er shi juan [volume 01]
爾雅新義 : 二十卷 [第一冊]
Creators: name: Lu, Dian, 1042-1102
name: 陸佃, 1042-1102
Publisher: name: The University of British Columbia
Year: 2018

description: Hand-written copy, on double leaves, East Asian binding.
Edition: [Chao ben]
Part1 data for Diverse tropical forests are more stable than monocultured rubber plantations
Creators: name: Sun, Zhongyi
name: Wang, Ziqin
name: Zhang, Runqing
name: Zhao, Junfu
name: Yin, Shuai
name: Wu, Lan
name: Tan, Zheng-Hong
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 300703
subject: Forest ecosystems
classificationCode: 410203
subject: Ecosystem function

description: The rapid expansion of rubber plantations (RB) in Southeast-Asia has raises concerns about ecosystem stability. This study compares the stability of RB and tropical forests (RF) in terms of long-term temporal stability, resilience, and resistance using satellite and reanalysis data.
title: Correspondence: C. Harrison Mann, Jr. and A.T. Lundberg, February 16, 1961- March 6, 1961
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
name: Lundberg, A.T.
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Arlington County (VA)
subject: Traffic

description: Letter A: typescript unsigned, 8.5" x 11" (21.6cm x 27.9cm), small tears on upper left corner of each page; Letter B: typscript signed, 8.5" x 11" (21.6cm x 27.9cm); Letter C: typescript unsigned, 8.5" x 11" (21.6cm x 27.9cm)
description: Correspondence: C. Harrison Mann, Jr. and A.T. Lundberg, County Manager of Arlington County, Virginia, discuss traffic problems in the Arlington area and Mann proposes several solutions. C. Harrison Mann, Jr. Collection 3.11