cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.
Creators: name: Hsun-Hsien  Chang
name: Moura, José M. F.
name: Yi-Jen L. Wu
name: Ho, Chien
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Contrast-enhanced magnetic resonance imaging (MRI) is useful to study the infiltration of immune cells, in particular macrophages. Contrast agents, for example ultra-small superparamagnetic iron oxide (USPIO) particles, administered intravenously into the blood stream will be engulfed by macrophages circulating in the circulation system. When a transplanted heart rejects, macrophages and other immune cells will infiltrate the rejecting tissue. Imaged by T*2 weighted MRI, USPIO-labeled macrophages will display dark pixel intensities. Detecting the presence of USPIO particles in the images facilitates the study of heart rejection. We cast the problem of detecting the presence of USPIO-labeled myocardium in the framework of spectral graph theory, and treat our decision function as a level set function on the image. The pixels with positive level set values correspond to the presence of immune cells, and negative to the absence. When the image is modeled by a graph, the spectral analysis of the graph Laplacian provides a basis to represent the level set function. We develop from the Cheeger constant of the graph an objective functional of the level set function. The minimization of the objective leads to the optimal level set function. Experimental results suggest the feasibility of our approach in the study of rejecting hearts.
Automated Detection of Solar Eruptions
Creators: name: Hurlburt, Neal
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Observation of the solar atmosphere reveals a wide range of motions, from small scale jets and spicules to global-scale coronal mass ejections. Identifying and characterizing these motions are essential to advancing our understanding the drivers of space weather. Both automated and visual identifications are currently used in identifying CMEs. To date, eruptions near the solar surface (which may be precursors to CMEs) have been identified primarily by visual inspection. Here we report on EruptionPatrol (EP): a software module that is designed to automatically identify eruptions from data collected by SDO/AIA. We describe the method underlying the module and compare its results to previous identifications found in the Heliophysics Event Knowledgebase. EP identifies eruptions events that are consistent with those found by human annotations, but in a significantly more consistent and quantitative manner. Eruptions are found to be distributed within 15Mm of the solar surface. They possess peak speeds ranging from 4 to 100 km/sec and display a power-law probability distribution over that range. These characteristics are consistent with previous observations of prominences.
description: 6 pages, 4 figures, 7th Solar Information Processing Workshop, to appear in Space Weather and Space Climate
Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content.
Creators: name: Padmanabhan, Krishnan
name: Urban, Nathan
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Although examples of variation and diversity exist throughout the nervous system, their importance remains a source of debate. Even neurons of the same molecular type have notable intrinsic differences. Largely unknown, however, is the degree to which these differences impair or assist neural coding. We examined the outputs from a single type of neuron, the mitral cells of the mouse olfactory bulb, to identical stimuli and found that each cell's spiking response was dictated by its unique biophysical fingerprint. Using this intrinsic heterogeneity, diverse populations were able to code for twofold more information than their homogeneous counterparts. In addition, biophysical variability alone reduced pair-wise output spike correlations to low levels. Our results indicate that intrinsic neuronal diversity is important for neural coding and is not simply the result of biological imprecision.
Evaluation of gamma irradiation on medicinal plants for both qualitative and quantitative analysis of phenolic acid
Creators: name: Khawory, Muhammad Hidhir
name: Amanah, Azimah
name: Salin, Nurul Hanim
name: Subki, Mohd Ferdaues Mohd
name: Nasim, Nurul Nadieya Mohd
name: Noordin, Mohamed Ibrahim
name: Wahab, Habibah A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: The aim of this study is to assess how gamma irradiation affects the chemical profiles of medicinal plants. Two different forms; methanol leaf extracts and dried leaves, of the three medicinal plants were investigated. Utilising FTIR, HPLC, and LCMS techniques, the qualitative measurement of gallic acid (GA) in three different medicinal plants for both plant extract and dried plant before and after the gamma radiation treatment was carried out. In the meantime, HPLC has been used to do a quantitative analysis of GA in these plants in order to show the percentage concentration of phenolic acid. For these medicinal herbs, the FTIR study revealed that both plant extract and dried plant had comparable functional groups both before and after gamma radiation therapy. The chromatogram of the HPLC profile for these medicinal plants was similar in chemical constituents before and after gamma irradiation, but the samples that were treated with gamma irradiation had a slight increase in intensity (between 0.0002-0.0009 Au). Additionally, gamma irradiation at levels of 6-12 kGy and 9-13 kGy caused the mass peak of GA to deteriorate in mass spectrometry analysis. Furthermore, the percentage concentration of GA increased significantly as the gamma radiation dose increased for both forms.
Chaos and chaos: the city as a complex phenomenon
Creators: name: Gargiulo, Carmela
name: Papa, Rocco
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: To say that the city is a dynamically complex system is to affirm that the city can be traced back to a set of components in relation to each other (system), that the processes of the system cannot be managed and controlled with deterministic tools (complex system) and, lastly, that the future evolution of the city-system cannot be predicted linearly on the basis of knowledge of the initial conditions (dynamically complex system). The degree of complexity reached by the city, as a modern expression of collective life, is such that it is unable to provide a compatible and adequate solution to the problems of the "city-system", which is subject, like all systems, to processes of entropy maximisation.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Ipsilateral whiskers suppress experience-dependent plasticity in the barrel cortex.
Creators: name: Glazewski, Stanislaw
name: Benedetti, Brett L.
name: Barth, Alison L.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Each cerebral hemisphere processes sensory input from both sides of the body, but the impact of this convergence on shaping and modifying receptive field properties remains controversial. Here we investigated the effect of chronic deprivation of ipsilateral sensory whiskers on receptive field plasticity in primary somatosensory cortex. In the absence of ipsilateral whiskers, cortical receptive fields were significantly larger than control after 1 week. Removal of all but a single whisker from one side of the face [single-whisker experience (SWE)] has been shown to result in the expansion of the cortical area responding to the spared whisker. We compared the effects of SWE in the presence (SWE-unilateral) and absence (SWE-bilateral) of ipsilateral whiskers. SWE-bilateral deprivation results in a significant increase in neuronal responses to spared whisker stimulation both in its cognate barrel column and in adjacent, surrounding barrel columns compared with control and SWE-unilateral deprived animals. Surround receptive fields in deprived columns were maintained in SWE-bilateral treated animals but depressed in SWE-unilateral animals. The increase in spared whisker responses was progressive with longer deprivation periods. These data show that ipsilateral whiskers can constrain receptive field size in the barrel cortex.
Toward greener and pandemic-proof cities? Policy response to Covid-19 outbreak in four global cities
Creators: name: Angiello, Gennaro
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: Starting from the relationship between urban planning and mobility management, TeMA has gradually expanded the view of the covered topics, always following a rigorous scientific in-depth analysis. This section of the Journal, Review Notes, is the expression of a continuous updating of emerging topics concerning relationships among urban planning, mobility and environment, through a collection of short scientific papers. The Review Notes are made of four parts. Each section examines a specific aspect of the broader information storage within the main interests of TeMA Journal. In particular, the Urban practices section aims at presenting recent advancements on relevant topics that underlie the challenges that the cities have to face. The present note provides an overview of the policies and initiatives undertaken in four global cities in response to the Covid-19 outbreak: New York City (US), Beijing (CN), Paris (FR) and Singapore (SG). A cross-city analysis is used to derive a taxonomy of urban policy measures. The contribution discusses the effectiveness of each measures in providing answers to epidemic threats in urban areas while, at the same time, improving the sustainability and resilience of urban communities.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Removal of heavy metal ions using nano-cellulose prepared from rice husk: validation by differential pulse voltammetry
Creators: name: Baraskar, P.N.
name: Samant, R.A.
name: Gurav, V.L.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: In this work, Cellulose was extracted from rice husk and chemically modified to produce Nano-Cellulose. It was characterized by FTIR, XRD, SEM/EDS, TEM, BET surface area analyzer, Particle size analyzer and tested for the removal of metal ions i.e. Zn(II), Cd(II), As(III), Pb(II) and Sn(II) from aqueous solution. The removal method was validated by differential pulse voltammetry (DPV). An adsorption experiment was performed to investigate the effects of initial pH, adsorbent dose, contact time and initial concentration of heavy metal ions on the adsorption capacity of nanocellulose. The experimental results revealed that the removal of metal ions on the nanocellulose was a pH-dependent process with the maximum adsorption capacity at the initial solution pH of 5–6. An adsorbent dose of 8mg/mL was sufficient for effective adsorption. In addition, the kinetics and equilibrium data are well described by pseudo-second-order kinetics and the Freundlich adsorption isotherm model at 50 min contact time and 50 mg/L initial concentration. Moreover, the desorption and re-adsorption performance was also studied, and the results revealed that the Nano-cellulose still showed good adsorption performance up to eight cycles of regeneration.
title: Gestion de la fumée dans les atriums : conception de différents systèmes
Creators: name: Lougheed, G. D.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 2000
Subjects: subject: fumée
subject: bâtiment
subject: atrium

description: Ce numéro traite de la conception de systèmes de gestion de la fumée pour des bâtiments pourvus d’atriums à partir d’une approche technique et en fonction des principes généraux énoncés dans le numéro précédent, Solution constructive n° 47.
description: This Update discusses the use of an engineered approach to the design of smoke management systems for atrium buildings, based on the principles of smoke management in atriums outlined in Construction Technology Update No. 47.
description: Also available in English: Considerations in the Design of Smoke Management Systems for Atriums
Environmental, social and economic sustainability in urban areas: a cool materials' perspective
Creators: name: Rosso, Federica
name: Franco, Stefano
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: Starting from the relationship between urban planning and mobility management, TeMA has gradually expanded the view of the covered topics, always following a rigorous scientific in-depth analysis. This section of the Journal, Review Notes, is the expression of a continuous updating of emerging topics concerning relationships among urban planning, mobility and environment, through a collection of short scientific papers. The Review Notes are made of four parts. Each section examines a specific aspect of the broader information storage within the main interests of TeMA Journal. In particular, the Economy, business and land use section aims at presenting recent advancements on relevant topics that underlie socio-economic relationships between firms and territories. The present note tackles the topic of cool materials for urban areas, as a mitigation strategy to counteract climate-change related issues. The most recent developments about cool materials demonstrate how they can boost environmental, social and economic sustainability and resilience in urban areas.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Rank deficiency of Kalman error covariance matrices in linear time-varying system with deterministic evolution
Creators: name: Gurumoorthy, Karthik S.
name: Grudzien, Colin
name: Apte, Amit
name: Carrassi, Alberto
name: Jones, Christopher K. R. T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 93E11, 93C05, 93B05, 60G35, 15A03

description: We prove that for linear, discrete, time-varying, deterministic system (perfect model) with noisy outputs, the Riccati transformation in the Kalman filter asymptotically bounds the rank of the forecast and the analysis error covariance matrices to be less than or equal to the number of non-negative Lyapunov exponents of the system. Further, the support of these error covariance matrices is shown to be confined to the space spanned by the unstable-neutral backward Lyapunov vectors, providing the theoretical justification for the methodology of the algorithms that perform assimilation only in the unstable-neutral subspace. The equivalent property of the autonomous system is investigated as a special case.
Jump-starting kinesin.
Creators: name: Hackney, David
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin discriminates among its many potential cargo molecules. Blasius et al. (see p. 11 of this issue) report that either binding of the cargo linker c-Jun N-terminal kinase-interacting protein 1 (JIP1) to the light chains (LCs) or binding of fasciculation and elongation protein zeta1 (FEZ1) to the heavy chains (HCs) is insufficient for activation but that activation occurs when both are present simultaneously. A related paper by Cai et al. (see p. 51 of this issue) provides structural insight into the conformation of the folded state in the cell obtained by fluorescence resonance energy transfer analysis.
Ecological transition: perspectives from U.S. and European cities
Creators: name: Guida, Carmen
name: Ugan, Jorge
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: Starting from the relationship between urban planning and mobility management, TeMA has gradually expanded the view of the covered topics, always remaining in the groove of rigorous scientific in-depth analysis. This section of the Journal, Review Notes, is the expression of a continuous updating of emerging topics concerning relationships between urban planning, mobility and environment, through a collection of short scientific papers written by young researchers. The Review Notes are made of four parts. Each section examines a specific aspect of the broader information storage within the main interests of TeMA Journal. In particular, the Urban planning literature review section aims at presenting recent books and journals, within global scientific panorama, on selected topics and issues. This contribution proposes a further insight into the complex ecological transition, with a focus to U.S. and European cities. Cities have faced a worldwide health and economic crisis due to the outbreak of a new coronavirus in 2019 and now, with progressive and massive vaccination and never experienced financial tools, a new era seems to start: significant financial resources, plenty of room for economic maneuvers may turn the ongoing pandemic into an opportunity, for the following years, to build more sustainable societies and environments. Within this scenario, urban areas play an essential role. According to shared and universal goals to achieve a more sustainable model of society and economy, how ecological transition is run by policymakers, stakeholders and citizens strongly depends on cities' backgrounds and structures.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Resilience as an urban strategy: The role of green interventions in recovery plans
Creators: name: Gaglione, Federica
name: Ayiine-Etigo, David Ania
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: Starting from the relationship between urban planning and mobility management, TeMA has gradually expanded the view of the covered topics, always following a rigorous scientific in-depth analysis. This section of the Journal, Review Notes, is a continuous update about emerging topics concerning relationships among urban planning, mobility and environment thanks to a collection of short scientific papers written by young researchers. The Review Notes are made up of five parts. Each section examines a specific aspect of the broader information storage within the main interests of the TeMA Journal. In particular: the Town Planning International Rules and Legislation Overview section aims at presenting the latest updates in the territorial and urban legislative sphere. The issue of the current recovery and resilience plans and the related reforms envisaged in them aim to give impetus to new forms of organization of urban systems and all its components. In this direction, the content of this review describes the reforms envisaged in the National Recovery and Resilience Plan of Italy and Germany with a focus on the due mission based on the green revolution and ecological transition. Furthermore, this review aims to define the role of these plans for future urban strategies to face the great challenges to which cities are called to respond such as climate change, energy efficiency while also respecting the principles of environmental sustainability.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation.
Creators: name: Yi-Jen L. Wu
name: Ye, Qing
name: Eytan, Danielle F.
name: Liu, Li
name: Bedda L. Rosario
name: T. Kevin  Hitchens
name: Fang-Cheng  Yeh
name: Rooijen, Nico Van
name: Ho, Chien
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: BACKGROUND: Current immunosuppressive therapy after heart transplantation either generally suppresses the recipient's entire immune system or is mainly targeting T-lymphocytes. Monocytes/macrophages are recognized as a hallmark of acute allograft rejection, but the roles that they play are not well characterized in vivo, because the tools for accessing in situ macrophage infiltration are lacking. In this study, we used MRI to investigate the role of macrophages in acute heart allograft rejection by cellular and functional MRI with selectively depleted systemic macrophages without affecting other leukocyte population, as well as to explore the possibility that macrophages could be an alternative therapeutic target.
METHODS AND RESULTS: A rodent heterotopic working heart-lung transplantation model was used for studying acute allograft rejection. Systemic macrophages were selectively depleted by treating recipient animals with clodronate-liposomes. Macrophage infiltration in the graft hearts was monitored by cellular MRI with in vivo ultrasmall superparamagnetic iron oxide particles labeling. Graft heart function was evaluated by tagging MRI followed by strain analysis. Clodronate-liposome treatment depletes circulating monocytes/macrophages in transplant recipients, and both cellular MRI and pathological examinations indicate a significant reduction in macrophage accumulation in the rejecting allograft hearts. In clodronate-liposome-treated group, allograft hearts exhibited preserved tissue integrity, partially reversed functional deterioration, and prolonged graft survival, compared with untreated controls.
CONCLUSIONS: Cardiac cellular and functional MRI is a powerful tool to explore the roles of targeted immune cells in vivo. Our results indicate that macrophages are essential in acute cardiac allograft rejection, and selective depletion of macrophages with clodronate-liposomes protects hearts against allograft rejection, suggesting a potential therapeutic avenue. Our findings show that there is a finite risk of forming an intraventricular mass, presumably from the cellular debris or lipid material. Further optimization of the dosing protocol is necessary before clinical applications.
Improved 8-point Approximate DCT for Image and Video Compression Requiring Only 14 Additions
Creators: name: Potluri, U. S.
name: Madanayake, A.
name: Cintra, R. J.
name: Bayer, F. M.
name: Kulasekera, S.
name: Edirisuriya, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Multimedia (cs.MM)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Numerical Analysis (math.NA)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Video processing systems such as HEVC requiring low energy consumption needed for the multimedia market has lead to extensive development in fast algorithms for the efficient approximation of 2-D DCT transforms. The DCT is employed in a multitude of compression standards due to its remarkable energy compaction properties. Multiplier-free approximate DCT transforms have been proposed that offer superior compression performance at very low circuit complexity. Such approximations can be realized in digital VLSI hardware using additions and subtractions only, leading to significant reductions in chip area and power consumption compared to conventional DCTs and integer transforms. In this paper, we introduce a novel 8-point DCT approximation that requires only 14 addition operations and no multiplications. The proposed transform possesses low computational complexity and is compared to state-of-the-art DCT approximations in terms of both algorithm complexity and peak signal-to-noise ratio. The proposed DCT approximation is a candidate for reconfigurable video standards such as HEVC. The proposed transform and several other DCT approximations are mapped to systolic-array digital architectures and physically realized as digital prototype circuits using FPGA technology and mapped to 45 nm CMOS technology.
description: 30 pages, 7 figures, 5 tables
Quantifying the urban built environment: a neighbourhood-scale analysis
Creators: name: Nkeki, Ndidi Felix
name: Asikhia, Monday Ohi
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: The quantification of the built environment has been approached from two major perspectives-regional-scale and neighbourhood-scale. Few studies have attempted to quantify the built environment from the neighbourhood-scale and none of these studies attempted to examine the interactions that exist between the respective built environment indicators and the spatial variation of such interaction which may help under the emerging travel-related prototypical neighbourhoods. Two types of datasets were used in the study and these are neighbourhood-based field surveys and data extracted from a satellite image. These were used to compute indicators which were in turn used to measure the built environment of Benin metropolitan region. The interaction between the indicators revealed that the quantification of the built environment categorised the region into 3 distinct prototypical neighbourhoods-pedestrian-oriented zones, transit-oriented zone, and car-oriented zone.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
KHOJA MUHAMMAD PORSO – A GREAT REPRESENTATIVE OF THE KHOJAGON-NAQSHBANDIYA SECT
Creators: name: Kholnazarov, Ismatillo
Publisher: name: Zenodo
Year: 2023

description: Studying the scientific heritage and views of Muhammad bin Muhammad bin Mahmud al-Hafizi al-Bukhari, one of the theorists of Sufism at the end of the 14th century, a major representative of the Khojagon-Naqshbandi sect, known as Khoja Muhammad Porso It allows us to study more deeply the teachings of Sufism, which arose in the heart of Sufism, and the original content of the philosophy of mysticism, which has been formed in the framework of Sufism for more than a thousand years.
Territorial disparities in Tuscan industrial assets: a model to assess agglomeration and exposure patterns
Creators: name: Altafini, Diego
name: Cutini, Valerio
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: Industrial agglomerates are considered drivers of urban development. This reiterative process of industrial growth, nevertheless, tends to increase regional territorial disparities, an asymmetrical development pattern that can lead to productive spaces’ underuse or abandonment. Although numerous economics studies about industrial distribution and territorial disparities were so far conceived, those are based on dated spatial methodologies. These consider space as an abstract background, hence, leaving unexplored several spatial relations between production, infrastructural networks and industrial agglomerates organization. Novel models ought to consider real attributes of space, being crucial to economic recovery in times of territorial constrains; with this in consideration, the paper objective is to construct and discuss a spatial-economic model tailored to assess territorial disparities in industrial agglomerates distribution and the condition here defined as territorial exposure. Exposure, represented by a composite spatial index, denotes disparities in territorial endowments, identified as factors of sensitivity or support to firms placed within industrial agglomerates, spatial conditions that can affect their capabilities to react to periods of economic recession and their post-crisis recovery. The model analyses Tuscany Region’s industrial structure and depicts territorial disparities in a GIS-based environment. The spatial knowledge produced can aid regional initiatives for economic recovery directed to Tuscan industries.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Mechanism of Mss116 ATPase reveals functional diversity of DEAD-Box proteins.
Creators: name: Wenxiang  Cao
name: Coman, Maria Magdalena
name: Ding, Steve
name: Henn, Arnon
name: Middleton, Elizabeth R.
name: Bradley, Michael J.
name: Rhoades, Elizabeth
name: Hackney, David
name: Pyle, Anna Marie
name: Cruz, Enrique M. De La
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Mss116 is a Saccharomyces cerevisiae mitochondrial DEAD-box RNA helicase protein that is essential for efficient in vivo splicing of all group I and group II introns and for activation of mRNA translation. Catalysis of intron splicing by Mss116 is coupled to its ATPase activity. Knowledge of the kinetic pathway(s) and biochemical intermediates populated during RNA-stimulated Mss116 ATPase is fundamental for defining how Mss116 ATP utilization is linked to in vivo function. We therefore measured the rate and equilibrium constants underlying Mss116 ATP utilization and nucleotide-linked RNA binding. RNA accelerates the Mss116 steady-state ATPase ∼7-fold by promoting rate-limiting ATP hydrolysis such that inorganic phosphate (P(i)) release becomes (partially) rate-limiting. RNA binding displays strong thermodynamic coupling to the chemical states of the Mss116-bound nucleotide such that Mss116 with bound ADP-P(i) binds RNA more strongly than Mss116 with bound ADP or in the absence of nucleotide. The predominant biochemical intermediate populated during in vivo steady-state cycling is the strong RNA-binding Mss116-ADP-P(i) state. Strong RNA binding allows Mss116 to fulfill its biological role in the stabilization of group II intron folding intermediates. ATPase cycling allows for transient population of the weak RNA-binding ADP state of Mss116 and linked dissociation from RNA, which is required for the final stages of intron folding. In cases where Mss116 functions as a helicase, the data collectively favor a model in which ATP hydrolysis promotes a weak-to-strong RNA binding transition that disrupts stable RNA duplexes. The subsequent strong-to-weak RNA binding transition associated with P(i) release dissociates Mss116-RNA complexes, regenerating free Mss116.
Metropolitan Cities supporting local adaptation processes. The case of the Metropolitan City of Venice
Creators: name: Magni, Filippo
name: Litt, Giovanni
name: Carraretto, Giovanni
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: Cities have a fundamental role in the adaptation and mitigation process to climate change. Even though cities will be the main subject of climate change impacts, they can propose solutions and build alternative scenarios. The difficulties that municipalities may encounter in their adaptation processes concern the lack of planning skills, technical knowledge, and human resources. To face these challenges Italian Metropolitan Cities can play a fundamental role in helping municipalities to plan and coordinate their efforts. The process in the Venetian territory has lasted many years and it has led to the awareness that local adaptation policies need to be addressed with broader support. The Metropolitan City of Venice has constructed a methodology for the planning of climatic adaptation. This methodology has been developed thanks to various plans and projects. These projects acted to increase the coordination between bodies, to define a broad area vision, to help municipalities to implement local actions. The role played by CMVe intends to direct public policies towards adaptation and mitigation in a structural way and with broad area governance. The process activated could be replicable in other Italian Metropolitan Cities in the approach and the result even if adapted to local needs.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
Robust Category-Level 6D Pose Estimation with Coarse-to-Fine Rendering of Neural Features
Creators: name: Ma, Wufei
name: Wang, Angtian
name: Yuille, Alan
name: Kortylewski, Adam
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: We consider the problem of category-level 6D pose estimation from a single RGB image. Our approach represents an object category as a cuboid mesh and learns a generative model of the neural feature activations at each mesh vertex to perform pose estimation through differentiable rendering. A common problem of rendering-based approaches is that they rely on bounding box proposals, which do not convey information about the 3D rotation of the object and are not reliable when objects are partially occluded. Instead, we introduce a coarse-to-fine optimization strategy that utilizes the rendering process to estimate a sparse set of 6D object proposals, which are subsequently refined with gradient-based optimization. The key to enabling the convergence of our approach is a neural feature representation that is trained to be scale- and rotation-invariant using contrastive learning. Our experiments demonstrate an enhanced category-level 6D pose estimation performance compared to prior work, particularly under strong partial occlusion.
title: Gestion de la fumée dans les atriums : principes généraux
Creators: name: Lougheed, G. D.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 2000
Subjects: subject: bâtiment
subject: incendie
subject: fumée

description: Dans un bâtiment pourvu d’un atrium, la migration de la fumée provoquée par un incendie peut mettre les occupants en danger de façon très sérieuse. Cet article, à l’usage des architectes et des gestionnaires de bâtiments, souligne quelques principes fondamentaux en matière de gestion de la fumée dans les atriums, principes qui doivent être bien compris pour améliorer la sécurité des occupants.
description: Fires in atrium buildings can pose a serious threat to occupants as a result of smoke migration. This Update, intended for building designers and property managers, outlines the basic principles of smoke management in atriums that must be understood in order to enhance occupant safety.
Analysis of the cumulative neutrino flux from Fermi-LAT blazar populations using 3 years of IceCube data
Creators: name: Glüsenkamp, Thorsten
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The recent discovery of a diffuse neutrino flux up to PeV energies raises the question of which populations of astrophysical sources contribute to this diffuse signal. One extragalactic candidate source population to produce high-energy neutrinos are Blazars. We present results from a likelihood analysis searching for cumulative neutrino emission from Blazar populations selected with the 2nd Fermi-LAT AGN catalog (2LAC) using an IceCube data set that has been optimized for the detection of individual sources. In contrast to previous searches with IceCube, the investigated populations contain up to hundreds of sources, the biggest one being the entire Blazar sample measured by the Fermi-LAT. No significant neutrino signal was found from any of these populations. Some implications of this non-observation for the origin of the observed PeV diffuse signal will be discussed.
description: 6 pages, 2 figures, proceedings for the RICAP-14 conference in Noto, Sicily, Sept. 30th - Oct. 3rd 2014
Modulation of kinesin half-site ADP release and kinetic processivity by a spacer between the head groups.
Creators: name: Hackney, David
name: Stock, Maryanne F.
name: Moore, Jodi
name: Patterson, Reid A.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: A series of modifications of the junction of the neck linker and neck coil of dimeric Drosophila kinesin were constructed to determine the influence of head orientation and spacing on the ATPase kinetics. Ala(345) is the first residue in the coiled-coil of the neck, and its replacement with glycine or proline produces no significant change in the k(cat) or K(0.5(MT)) values for activation of their ATPase by microtubules (MTs) or in their k(bi(ratio)) value for the average number of ATP molecules hydrolyzed during a processive encounter with a MT. Addition or deletion of a single amino acid at the junction produces only modest changes with less than a 2-fold reduction in kinetic processivity. Insertion of a spacer of 6 or 12 additional amino acids at the neck linker junction increases the K(0.5(MT)) value by 3-4-fold with a corresponding decrease in kinetic processivity. The sliding velocities of all the mutant constructs under multimotor conditions are within 30% of the wild-type value. All the constructs with single residue changes exhibit half-site ADP release on binding to MTs. The constructs with long insertion, however, rapidly release both ADP molecules per dimer on binding to a MT, indicating that the steric constraints that prevent release of ADP from the tethered head of wild-type kinesin have been relieved by the long insertions. The constructs with long inserts have decreased kinetic processivity and dissociate from the MT during ATP hydrolysis 3-fold faster than wild-type.
title: Une méthode d'évaluation des matériaux et des systèmes d'étanchéité à l'air
Creators: name: Di Lenardo, Bruno
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 2000
Subjects: subject: air
subject: construction
subject: codes

description: Cet article explique les caractéristiques et le rôle du système d'étanchéité à l'air dans l'enveloppe du bâtiment, tel que le définit le Code national du bâtiment du Canada. Il traite des exigences du Code ainsi que des critères d'évaluation du Centre canadien de matériaux de construction, indispensables pour déterminer la conformité d'un système à ces exigences.
description: This Update explains the purpose and characteristics of the air barrier system in the building envelope as defined by the National Building Code of Canada. It discusses the code requirements for these systems and explains the role of the Canadian Construction Material Centre's evaluation criteria in determining whether a system meets these requirements.
BFS 10: A nascent bipolar H II region in a filamentary molecular cloud
Creators: name: Larose, Nicholas
name: Kerton, C. R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a study of the compact blister HII region BFS 10 and its highly filamentary molecular cloud. We utilize 12CO observations from the Five College Radio Astronomy Observatory to determine the distance, size, mass, and velocity structure of the molecular cloud. Infrared observations obtained from the UKIRT Infrared Deep Sky Survey and the Spitzer Infrared Array Camera, as well as radio continuum observations from the Canadian Galactic Plane Survey, are used to extract information about the central HII region. This includes properties such as the ionizing photon rate and infrared luminosity, as well as identifying a rich embedded star cluster associated with the central O9 V star. Time-scales regarding the expansion rate of the HII region and lifetime of the ionizing star reveal a high likelihood that BFS 10 will develop into a bipolar HII region. Although the region is expected to become bipolar, we conclude from the clouds velocity structure that there is no evidence to support the idea that star formation at the location of BFS 10 was triggered by two colliding clouds. A search for embedded young stellar objects (YSOs) within the molecular cloud was performed. Two distinct regions of YSOs were identified; one region associated with the rich embedded cluster and another sparse group associated with an intermediate mass YSO.
description: 9 pages, 7 figures, accepted for publication in the Monthly Notices of the Royal Astronomical Society
Population pharmacokinetics of lenalidomide in Chinese patients with influence of genetic polymorphisms of ABCB1
Creators: name: Liang, Xiaoxiao
name: Huang, Xin
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Other Pharmacy and Pharmaceutical Sciences
subject: Pharmacy and Pharmaceutical Sciences
subject: Medicine and Health Sciences

description: Affected by differences in the pharmacokinetics (PK) of lenalidomide, the toxicity of lenalidomide varies among different patients, with severe toxicity leading to dose reduction or discontinuation. The differences in the PK of lenalidomide may be related to factors such as patients’ physiological characteristics, pathological characteristics and gene polymorphisms et al., which may also affect its toxicity. The aim of this study is to establish a population pharmacokinetic (PPK) model of lenalidomide and explore factors associated with the adverse events (AEs) of lenalidomide from a PK perspective.
Experimental Observation of Large Chern numbers in Photonic Crystals
Creators: name: Skirlo, Scott A.
name: Lu, Ling
name: Yan, Qinghui
name: Igarashi, Yuichi
name: Joannopoulos, John
name: Soljacic, Marin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Despite great interest in the quantum anomalous Hall phase and its analogs, all experimental studies in electronic and bosonic systems have been limited to a Chern number of one. Here, we perform microwave transmission measurements in the bulk and at the edge of ferrimagnetic photonic crystals. Bandgaps with large Chern numbers of 2, 3, and 4 are present in the experimental results which show excellent agreement with theory. We measure the mode profiles and Fourier transform them to produce dispersion relations of the edge modes, whose number and direction match our Chern number calculations.
description: This experimental work was accepted to PRL on Oct. 13, 2015. Our theoretical work from PRL http://dx.doi.org/10.1103/PhysRevLett.113.113904
MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice.
Creators: name: Foley, Lesley
name: O'Meara, Alia M. Iqbal
name: Wisniewski, Stephen R.
name: T. Kevin  Hitchens
name: Melick, John A.
name: Ho, Chien
name: Jenkins, Larry W.
name: Kochanek, Patrick M.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after traumatic brain injury (TBI). We recently developed a mouse combined injury model of TBI and HS using a controlled cortical impact (CCI) model and showed that 90 minutes of HS can exacerbate neuronal death in hippocampus beneath the contusion. This combined injury model has three clinically relevant phases, a shock, pre hospital, and definitive care phases. Mice were randomly assigned to four groups, shams as well as a CCI only, an HS only, and a CCI+HS groups. The CCI and HS reduced cerebral blood flow (CBF) in multiple regions of interest (ROIs) in the hemisphere ipsilateral and contralateral to injury. Hemorrhagic shock to a level of ∼30 mm Hg exacerbated the CCI-induced CBF reductions in multiple ROIs ipsilateral to injury (hemisphere and thalamus) and in the hemisphere contralateral to injury (hemisphere, thalamus, hippocampus, and cortex, all P
Former military sites and post-Covid-19 city in Italy. May their reuse mitigate the pandemic impacts?
Creators: name: Camerin, Federico
Publisher: name: TeMA - Journal of Land Use, Mobility and Environment
Year: 2021

description: The presence of former military settlements, along with other abandoned spaces in the Italian cities, constitutes an opportunity for developing inclusive and green cities through a good governance, especially after the 2020 pandemic outbreak. This paper develops an analytical matrix for comparing and evaluating the redevelopment projects of a number of case studies in the Italian metropolitan cities of Bologna, Milan, Rome, and Turin in the face of the challenges of the post-COVID-19 issues. Although the difficulties to evaluate still ongoing redevelopment projects, I found two main results. First, the Italian political and economic context is what most influenced the redevelopment process and not so much the intrinsic characteristics of former military sites. Second, it seems that the reuse of these urban voids will not match a couple of features of the so-called post-COVID-19 features, i.e. inclusive and good governance, though the redevelopments can seemingly develop green cities.
description: TeMA - Journal of Land Use, Mobility and Environment, Vol 14 No 2 (2121): The city challenges and external agents. Methods, tools and best practices
title: Comment garantir une bonne performance sismique avec des habitations à ossature de bois à plate-forme
Creators: name: Rainer, J. H.
name: Karacabeyli, E.
Publisher: name: Conseil national de recherches du Canada. Institut de recherche en construction
Year: 2000
Subjects: subject: ossature de bois
subject: tremblements de terre
subject: construction

description: Cet article présente une analyse de la bonne performance des habitations à ossature de bois à plate-forme qui a pu être observée lors de tremblements de terre. Les auteurs apportent certaines solutions à des problèmes pratiques et soulignent les nouveautés en matière de technologie, de normes et de codes.
description: This Update reviews the generally good performance of platform-frame wood housing in earthquakes, presents solutions to some problems that occur in practice, and outlines new developments in technology, standards and codes.