cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Micro-credentials and micro-degrees. Current developments and potentials for educational practice based on the example of the AI Campus
Creators: name: Flasdick, Julia
name: Mah, Dana-Kristin
name: Bernd, Mike
name: Rampelt, Florian
Publisher: name: Zenodo
Year: 2023
Subjects: AI
Artificial Intelligence
OER
Open Educational Resources
AI Campus
Online Course
EdTech

description: Micro-credentials and micro-degrees are increasingly being discussed in education policy and practice as a flexible and innovative form of qualification. This discussion paper outlines the current status of national, European and international activities on micro-credentials and micro-degrees on digital learning platforms, in higher education and in vocational education. Taking the AI Campus – the Learning Platform for Artificial Intelligence – as a use case, it presents current practical developments and perspectives. Central to this is the presentation of a working definition of micro-credentials and microdegrees, considering the current academic discourse, as well as the demonstration of two planned AI Campus micro-degree programmes. Finally, an outlook will be offered related to the AI Campus’ plans for advancing the development of micro-degrees and helping them to take shape. The focus of this paper is on the German and European university landscape. This discussion paper is a translation of the original German paper published in August 2022. Relevant studies and data are as of mid-2022. The examples of the AI Campus have been updated to early 2023. The AI Campus is an R&D project funded by the German Federal Ministry of Education and Research (BMBF). The learning opportunities marked as "AI Campus Original" are also implemented as R&D projects. The AI Campus has been available to the public as a beta version since July 2020 and is in continuous development: www.ai-campus.org
Additional file 2 of Biofilm of Klebsiella pneumoniae minimize phagocytosis and cytokine expression by macrophage cell line
Creators: name: Rathore, Sudarshan Singh
name: Cheepurupalli, Lalitha
name: Gangwar, Jaya
name: Raman, Thiagarajan
name: Ramakrishnan, Jayapradha
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2: Table S2. Statistical analysis of macrophage interactions. t-test was performed for the macrophage interactions exposed to the heat-inactivated or live biofilm (Fig. 3).
Partitions of Correlated N-Qubit Systems
Creators: name: Phoenix, Simon J. D
name: Khan, Faisal Shah
name: Teklu, Berihu
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The production and manipulation of quantum correlation protocols will play a central role where the quantum nature of the correlation can be used as a resource to yield properties unachievable within a classical framework is a very active and important area of research. In this work, we provide a description of a measure of correlation strength between quantum systems, especially for multipartite quantum systems.
description: 14 pages, 3 figures
104. A cytokine-mediated role of B cells in giant cell arteritis
Creators: name: Graver1, Jacoba
name: Jiemy1, William
name: Wayel Abdulahad1
name: Heeringa2, Peter
name: Altulea1, Dania
name: Annemieke Boots1, MD
name: Brouwer1, Elisabeth
name: MD. Maria Sandovici1
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Giant cell arteritis (GCA) is vasculitis of large- and medium-sized arteries classically regarded as a T cell and macrophages mediated disease. B cells are clearly detected in the inflamed arteries, but their exact role in the pathogenesis of GCA is unclear. As the knowledge on the antibody-independent functions of B cells is growing, we sought to determine cytokine production by B cells in GCA and their effect on macrophages, crucial players in the pathogenesis of GCA. Methods: We performed immunohistochemistry on temporal artery (n=11) and aorta tissue (n=10) form GCA patients to detect lesional B cells and cytokines (IL-6, GM-CSF, TNFα, IFNγ, and IL-10). The capacity of circulating B cells to produce cytokines was assessed in vitro by stimulating PBMC with CpG and PMA from treatment-naïve GCA patients (n=11), polymyalgia rheumatica patients (PMR, n=10) and 15 age- and sex-matched HCs. Intracellular detection of cytokines by B cells (effector: IL-6, GM-CSF, TNFα, IFNγ and regulatory: IL-10) was performed using flow cytometry. To assess the skewing potential on macrophages, THP-1 derived macrophages were exposed to conditioned medium from stimulated B cells followed by qPCR analysis of IL-23, IL-6, IL1β, MMP9 and YKL40 mRNA expression. Results: B cells in GCA-affected arteries express IL-6, GM-CSF, TNFα, IFNγ and IL-10. Stimulated peripheral B cells from GCA patients showed enhanced frequencies of IL-6+ (median (IQR); 44 (41-52)) and TNFα+IL-6+ B cells (12 (8-24)) compared to HC (28 (23-39) and 6 (4-24) respectively). Production of effector cytokines by B cells was diminished after glucocorticoid treatment. In vitro B cell conditioned medium was capable of skewing macrophages towards a pro-inflammatory and tissue destructive phenotype expressing IL-6, IL-1β, TNFα, IL-23, YKL40 and MMP9. Conclusions: Our results indicate that B cells may contribute to the vasculopathy in giant cell arteritis via antibody independent functions. Cytokines produced by activated B cells can influence the vascular wall microenvironment and polarize macrophages towards a proinflammatory and tissue destructive phenotype known to be active at the site of vascular inflammation. Our data provide a rationale for B cell targeted therapy in GCA patients. Disclosures: none.
Additional file 3 of Biofilm of Klebsiella pneumoniae minimize phagocytosis and cytokine expression by macrophage cell line
Creators: name: Rathore, Sudarshan Singh
name: Cheepurupalli, Lalitha
name: Gangwar, Jaya
name: Raman, Thiagarajan
name: Ramakrishnan, Jayapradha
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 3: Table S3. Statistical analysis of cytokine gene expression in Raw264.7 macrophages. Cytokines gene expression macrophage Klebsiella biofilm interaction analysis by Two Way ANOVA followed by Tukey's multiple comparisons test (TLR2, iNOS, IL-6, IL-β1, IFN-γ, IL-4, IL-12, TNF-α and IL-10) (Fig. 4).
Freeform shape optimization of a compact DC photo-electron gun using isogeometric analysis
Creators: name: Förster, Peter
name: Schöps, Sebastian
name: Enders, Joachim
name: Herbert, Maximilian
name: Simona, Abele
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: G.1.8; I.6; J.2; J.6
subject: 35Q60, 65N30, 65D07 (Primary) 78A30, 78A35, 78M10 (Secondary)

description: Compact DC high-voltage photo-electron guns are able to meet the sophisticated demands of high-current applications such as energy recovery linacs. A main design parameter for such sources is the electric field strength, which depends on the electrode geometry and is limited by the field emission threshold of the electrode material. In order to minimize the maximum field strength for optimal gun operation, isogeometric analysis (IGA) can be used to exploit the axisymmetric geometry and describe its cross section by non-uniform rational B-splines, the control points of which are the parameters to be optimized. This computationally efficient method is capable of describing CAD-generated geometries using open source software (GeoPDEs, NLopt, Octave) and it can simplify the step from design to simulation. We will present the mathematical formulation, the software workflow, and the results of an IGA-based shape optimization for a planned high-voltage upgrade of the DC photogun teststand Photo-CATCH at TU Darmstadt. The software builds on a general framework for isogeometric analysis and allows for easy adaptations to other geometries or quantities of interest. Simulations assuming a bias voltage of -300 kV yielded maximum field gradients of 9.06 MV/m on the surface of an inverted insulator electrode and below 3 MV/m on the surface of the photocathode.
ANALISI NUMERICA DELLA PRESTAZIONE ENERGETICA ANNUALE DI EDIFICI IN LEGNO IN CILE
Creators: name: Dongellini, Matteo
Publisher: name: Zenodo
Year: 2020
Subjects: BIGWOOD INTERREG
timber constructions
multi-storey timber buildings
LCA
simulation
climate

description: • Presentazione del caso studio
 • Analisi delle zone climatiche cilene
 • Modifica dell'involucro dell'edificio • CLT • Telaio in legno • Muratura • Simulazione dinamica dell’edificio
 • Ottimizzazione della dotazione impiantistica
 • Analisi Life Cycle Assessment (LCA)
 • Conclusioni
103. CD19 CAR T cells prevent the development of ANCA-induced NCGN in a mouse model
Creators: name: Doerte Lodka2
name: Zschummel3, Maria Zschummel
name: Rousselle2, Anthony
name: Kettritz1, Ralph
name: Hoepken3, Uta
name: Schreiber1, Adrian
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: ANCA induced vasculitides and NCGN are potentially life threatening and current therapies rely largely on cytotoxic drugs or B cell depleting antibodies. Chimeric antigen receptor T cells (CAR T cells) are genetically modified to express a protein consisting of intracellular T cell receptor domains coupled to an extracellularly expressed antibody domain. The specificity of the antibody part determines which target cells are bound and destroyed by the CAR T cells. The use of CAR T cells in autoimmune diseases is a promising new therapeutic approach. As ANCA are important inductors of ANCA-associated vasculitides (AAVs) depletion of ANCA-producing B cells could be potentially beneficial for AAV therapy. Here we wanted to clarify whether CD19 CAR T cells are able to deplete B cells including ANCA-producing B cells and by that remove disease-inducing ANCAs and prevent disease onset. Methods: To assess the potential of a CD19 CAR T cell treatment approach, anti-MPO NCGN was induced by immunization of MPO-/- mice with murine MPO, subsequent irradiation and transplantation with hematopoietic cells from WT mice. Additionally, CD19 CAR T cells and SP6 CAR T cells (control) were transferred intravenously. Effects on disease severity were analyzed by histological examination of kidney sections and by kidney, blood and bone marrow flow cytometry analysis. Results: CD19 CAR T cells showed a stable engraftment in the transplanted animals as both two and five weeks after administration the cells were detectable in bone marrow, spleen and peripheral blood. Furthermore, mice receiving CD19 CAR T cells had a strongly reduced frequency of CD19-expressing endogenous B cells in the bone marrow, spleen and peripheral blood. This resulted in decreasing anti-MPO titers in CD19 CAR T treated animals. Finally, analysis of kidney histology revealed protection from NCGN induction with a decrease in crescentic or necrotic glomeruli in CD19 CAR T treated animals. Conclusion: Our data suggest that depletion of CD19 B cells by administration of CD19 CAR T cells is an effective therapeutic option in murine anti-MPO induced NCGN. Disclosures: None.
The Influence of Mergers on Scatter and Evolution in Sunyaev-Zel'dovich Effect Scaling Relations
Creators: name: Yu, Liang
name: Nelson, Kaylea
name: Nagai, Daisuke
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Sunyaev-Zel'dovich effect (SZE) observable-mass (Y-M) scaling relation is a promising technique for obtaining mass estimates for large samples of galaxy clusters and holds a key to studying the nature of dark matter and dark energy. However, cosmological inference based on SZE cluster surveys is limited by our incomplete knowledge of bias, scatter, and evolution in the Y-M relation. In this work, we investigate the effects of galaxy cluster mergers on the scaling relation using the Omega500 high-resolution cosmological hydrodynamic simulation. We show that the non-thermal pressure associated with merger-induced gas motions contributes significantly to the bias, scatter, and evolution of the scaling relation. After the merger, the kinetic energy of merging systems is slowly converted into thermal energy through dissipation of turbulent gas motions, which causes the thermal SZE signal to increase steadily with time. This post-merger evolution is one of the primary source of bias and scatter in the Y-M relation. However, we show that when the missing non-thermal energy is accounted for, the resulting relation exhibits little to no redshift evolution and the scatter around the scaling relation is ~20-30 % smaller than that of the thermal SZE signal alone. Our work opens up a possibility to further improve the current robust mass proxy, Y, by accounting for the missing non-thermal pressure component. We discuss future prospect of measuring internal gas motions in galaxy clusters and its implication for cluster-based cosmological tests.
description: 9 pages, 4 figures, 1 table. Accepted to ApJ May 21, 2015
Additional file 1 of Health systems resilience in practice: a scoping review to identify strategies for building resilience
Creators: name: Forsgren, Lena
name: Tediosi, Fabrizio
name: Blanchet, Karl
name: Saulnier, Dell D
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Database search strategies. Detailed search strategies used in the databases.
Parametric Distributionally Robust Optimisation Models for Resource and Inventory Planning Problems
Creators: name: Black, Ben
Publisher: name: Lancaster University
Year: 2023

description: Parametric probability distributions are commonly used for modelling uncertain demand and other random elements in stochastic optimisation models. However, when the distribution is not known exactly, it is more common that the distribution is either replaced by an empirical estimate or a non-parametric ambiguity set is built around this estimated distribution. In the latter case, we can then hedge against distributional ambiguity by optimising against the worst-case objective value over all distributions in the ambiguity set. This methodology is referred to as distributionally robust optimisation. When applying this approach, the ambiguity set necessarily contains non-parametric distributions. Therefore, applying this approach often means that any information about the true distribution’s parametric family is lost. This thesis introduces a novel framework for building and solving optimisation models under ambiguous parametric probability distributions. Instead of building an ambiguity set for the true distribution, we build an ambiguity set for its parameters. Every distribution considered by the model is then a member of the same parametric family as the true distribution. We reformulate the model using discretisation of the ambiguity set, which can result in a large, complex problem that is slow to solve. We first develop the parametric distributionally robust optimisation framework for a workforce planning problem under binomial demands. We then study a budgeted, multi-period new svendor model under Poisson and normal demands. In these first two cases, we develop fast heuristic cutting surface algorithms using theoretical properties of the cost function. Finally, we extend the framework into the dynamic decision making space via robust Markov decision processes. We develop a novel projectionbased bisection search algorithm that completely eliminates the need for discretisation of the ambiguity set. In each case, we perform extensive computational experiments to show that our algorithms offer significant reductions in run times with only negligible losses in solution quality.
Additional file 2 of Health systems resilience in practice: a scoping review to identify strategies for building resilience
Creators: name: Forsgren, Lena
name: Tediosi, Fabrizio
name: Blanchet, Karl
name: Saulnier, Dell D
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 2: Table 2. Summary of included studies. Overview table of all papers included in the study, with author name, year, objective, design and method, context, and summary of main findings.
Anarchic Yukawas and top partial compositeness: the flavour of a successful marriage
Creators: name: Cacciapaglia, Giacomo
name: Cai, Haiying
name: Flacke, Thomas
name: Lee, Seung J.
name: Parolini, Alberto
name: Serôdio, Hugo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The top quark can be naturally singled out from other fermions in the Standard Model due to its large mass, of the order of the electroweak scale. We follow this reasoning in models of pseudo Nambu Goldstone Boson composite Higgs, which may derive from an underlying confining dynamics. We consider a new class of flavour models, where the top quark obtains its mass via partial compositeness, while the lighter fermions acquire their masses by a deformation of the dynamics generated at a high flavour scale. One interesting feature of such scenario is that it can avoid all the flavour constraints without the need of flavour symmetries, since the flavour scale can be pushed high enough. We show that both flavour conserving and violating constraints can be satisfied with top partial compositeness without invoking any flavour symmetry for the up-type sector, in the case of the minimal SO(5)/SO(4) coset with top partners in the four-plet and singlet of SO(4). In the down-type sector, some degree of alignment is required if all down-type quarks are elementary. We show that taking the bottom quark partially composite provides a dynamical explanation for the hierarchy causing this alignment. We present explicit realisations of this mechanism which do not require to include additional bottom partner fields. Finally, these conclusions are generalised to scenarios with non-minimal cosets and top partners in larger representations.
description: 37 pages, 1 figure, v2: typos fixed, Eq. (3.44) added, version corresponds to published article in JHEP
Prestazione energetica e durabilità degli edifici in legno: stato dell'arte e case studies
Creators: name: Erlacher, Peter
Publisher: name: Zenodo
Year: 2020
Subjects: BIGWOOD INTERREG
timber constructions
multi-storey timber buildings
LCA
comfort
susatinability
environment
case studies
construction details

description: Prestazione energetica e durabilità degli edifici in legno: stato dell'arte e case studies
101. Production mechanism of anti-glomerular basement membrane antibody in anti-neutrophil cytoplasmic antibody-associated vasculitis
Creators: name: Nishibata1, Yuka
name: Masuda1, Sakiko
name: Daigo Nakazawa2
name: Tanaka3, Satoshi
name: Utano Tomaru4
name: Ishizu1, Akihiro
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is sometimes complicated by anti-glomerular basement membrane (GBM) disease. Proteases, including elastase, released from neutrophils activated by ANCA are implicated in the pathogenesis of AAV. Epitopes of anti-GBM antibody exist in the α3-subunit non-collagenous (NC1) domain of collagen type IV [Col (IV)]. This region, called α3(IV)NC1, is structurally cryptic. This study aimed to determine the production mechanism of anti-GBM antibody in AAV. Methods: We first examined whether α3(IV)NC1 could be revealed by the digestion of formalin-fixed, paraffin-embedded (FFPE) normal kidney sections and Col (IV) by proteases, including neutrophil elastase, using immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA). Next, the reveal of α3(IV)NC1 and the infiltration of CD11c+ macrophages in the affected kidneys of patients with AAV and other diseases were evaluated by IHC and immunofluorescent staining using FFPE sections. Finally, the production of anti-GBM antibody in AAV rats was determined by ELISA. Results: α3(IV)NC1 was revealed by the digestion of FFPE normal kidney sections and Col (IV) by proteases. Although the reveal of α3(IV)NC1 was observed in sclerotic glomeruli regardless of causative diseases, CD11c+ macrophages near α3(IV)NC1 were characteristics of AAV. Anti-GBM antibody was produced subsequent to ANCA in some AAV rats. IHC demonstrated the reveal of α3(IV)NC1 in affected renal tissues and the infiltration of CD11c+ macrophages around the sites. Conclusions: The collective findings suggest that, in AAV, proteases released from neutrophils activated by ANCA digest Col (IV) and result in the reveal of α3(IV)NC1, CD11c+ macrophages present GBM epitopes, and then the host’s immune system produce anti-GBM antibody. This corresponds to the concept of intermolecular epitope spreading, which is related to disease conversion and complication. For example, the implication of intermolecular epitope spreading has been discussed in a conversion from pemphigus vulgaris to pemphigus foliaceus and in a complication of Hashimoto’s thyroiditis with Graves’ disease. To our knowledge, this is the first report suggesting that intermolecular epitope spreading is involved in the production of anti-GBM antibody in AAV. Disclosures: Pre-print: https://www.researchsquare.com/article/rs-322082/v1
Real photons from vacuum fluctuations in optomechanics: the role of polariton interactions
Creators: name: Lemonde, Marc-Antoine
name: Clerk, Aashish A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study nonlinear interactions in a strongly driven optomechanical cavity, in regimes where the interactions give rise to resonant scattering between optomechanical polaritons and are thus strongly enhanced. We use a Keldysh formulation and self-consistent perturbation theory, allowing us to include self energy diagrams at all orders in the interaction. Our main focus is understanding how non-equilibrium effects are modified by the polariton interactions, in particular the generation of non-zero effective polariton temperatures from vacuum fluctuations (both in the incident cavity drive and in the mechanical dissipation). We discuss how these effects could be observed in the output spectrum of the cavity. Our work also provides a technical toolkit that will be useful for studies of more complex optomechanical systems.
description: 22 pages, 12 figures
Structure and soft magnetic properties of single-domain Mg$_{1-x}$Ni$_x$Fe$_2$O$_4$ ($0 \le x \le 1.0$) nanocrystals
Creators: name: Kassem, M. A.
name: El-Fadl, A. Abu
name: Hassan, A. M.
name: Gismelssed, A. M.
name: Nakamura, H.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The effects of Ni$^{2+}$ substitution on the structure (lattice parameters, cations distribution, average cations radii, cation-cation/anion bond lengths and angles) and the soft magnetic properties of Mg$_{1-x}$Ni$_x$Fe$_2$O$_4$ ($0 \le x \le 1.0$) nanocrystals have been studied by x-ray diffraction with Rietveld refinement, transmittance electron microscopy, Mossbauer spectroscopy and magnetization measurements. The mostly inverse spinel structure was found in MgFe$_2$O$_4$ nanoparticles and the inversion factor is further increased by Ni-substitution up to a complete inversion in NiFe$_2$O$_4$. The synthesized ferrites with a small particle size (20 - 30 nm) exhibit soft magnetic properties of a single-domain behavior with critical domain size about 30 - 40 nm. An observed monotonic increase in magnetization and drastic decrease in coercivity at 5 K by Ni-substitution result in a lowest anisotropy constant Ku (2.8 kJ/m3) for x = 0.5. We discuss the evolution of magnetic properties by Ni-substitution in a correlation with a subsequent cations-redistribution between sites of the two sublattices and corresponding structural changes in the inter-ionic distances.
description: 23 pages, 7 captioned figures, 6 tables
PSSOH & Desc0n 6.0 joint workshop "How to assemble Klimerko"
Creators: name: Milošević, Željka Desiree
Publisher: name: Zenodo
Year: 2020
Subjects: workshop
air quality
IoT
open hardware
measurement

description: Presentation held at the University of Belgrade - School of Electrical Engineering during post-conference workshop on how to assemble Klimerko organized by PSSOH and Descon 6.0. The lecture was recorded and the video of presentation held by Desiree together with the Q&A session with Vanja Stanić (Klimerko creator) is available at https://youtu.be/qBsHbX_rxH0.
EOSC-Pillar D4.4 National Service Registry Prototype
Creators: name: Candela, Leonardo
name: Cirillo, Roberto
name: Frosini, Luca
name: Mangiacrapa, Francesco
name: Sinibaldi, Fabio
name: Antonio, Fabrizio
name: Chiavarini, Beatrice
name: Lorini, Marco
Publisher: name: Zenodo
Year: 2021
Subjects: EOSC
Open Science
Catalogue

description: National initiatives willing to systematically collect and present the service offerings of interest for their designated community are called to set up and operate a registry or catalogue of such services. This brief report documents the working prototype of a National Service Registry developed by EOSC-Pillar. This prototype is characterised by two distinguishing features: (i) the development of the catalogue is the result of a collaborative oriented co-creation activity and (ii) conceived to be interoperable with the EOSC Catalogue.
85. Identification of a Novel Susceptibility Locus for Small Vessel Vasculitis with Autoantibodies Against Myeloperoxidase
Creators: name: Johanna Dahlqvist1, 2
name: Sennblad3, Bengt
name: Ekman4, Diana
name: Kozyrev2, Sergey
name: Nordin2, Jessika
name: Karlsson2, Åsa
name: Meadows2, Jennifer
name: Hellbacher1, Erik
name: Rantapää-Dahlqvist5, Solbritt
name: Berglin5, Ewa
name: Stegmayr5, Bernd
name: Baslund6, Bo
name: Palm7, Øyvind
name: Haukeland8, Hilde
name: Gunnarsson9, Iva
name: Bruchfeld10, Annette
name: Segelmark11, Mårten
name: Ohlsson11, Sophie
name: Mohammad11, Aladdin
name: Svärd12, Anna
name: Rille Pullerits13
name: Herlitz14, Hans
name: Söderbergh15, Annika
name: Pielberg2, Gerli Rosengren
name: Pielberg2, Gerli Rosengren
name: Rosenberg2, Lina Hultin
name: Bianchi2, Matteo
name: Murén2, Eva
name: Roald Omdal16, 17
name: Jonsson17, Roland
name: Maija-Leena Eloranta1
name: Rönnblom1, Lars
name: Söderkvist18, Peter
name: Knight1, Ann
name: Eriksson18, Per
name: Kerstin Lindblad-Toh2, 19
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: ANCA-associated vasculitides (AAV) are rare but aggressive autoimmune disorders. The pathogenesis of the disorders is complex and still poorly understood; only a few genetic loci have been associated with AAV. The aim of this project was to identify and characterize novel susceptibility loci for AAV positive for myeloperoxidase (MPO) or proteinase 3 (PR3) ANCA. Methods: Genetic association analyses were performed after Illumina sequencing of 1853 genes and subsequent replication with genotyping of candidate single-nucleotide polymorphisms (SNPs) in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) and 1589 controls. Data were analysed using logistic regression with a P value threshold for significance of < 9.1 x 10-7. A novel AAV-associated SNP was analysed for allele-specific effects on gene expression using luciferase reporter assay. Results: Associations between PR3-ANCA positive (+) AAV and the HLA-DPB1, HLA-DPA1 and SERPINA1 genes and between MPO-ANCA+ AAV and the HLA–DQB1 locus identified in previous genome-wide studies were confirmed in the present study. In addition, a rare SNP located in the BACH2 gene (rs78275221) was identified as significantly associated with MPO-ANCA+ AAV (P = 7.9 x 10-7, Odds ratio = 3.0 in meta-analysis). The rare allele of the novel disease-associated SNP affected downstream gene expression in primary endothelial cells, specifically. Conclusion: This study confirms previous findings of genetic associations specific for PR3-ANCA+ and MPO-ANCA+ AAV, respectively. A novel susceptibility locus for MPO-ANCA+ AAV was identified, where the disease-associated SNP may facilitate the development of autoimmunity through a negative effect on gene expression in specific cell types. Disclosures: None.
ADAPTING TO CHANGE - THE EVOLUTION OF TRAINING AND DEVELOPMENT IN THE FBI
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2023
Subjects: Emotional Intelligence
Law Enforcement
FBI

description: This article explores the critical role of emotional intelligence coaching within the Federal Bureau of Investigation (FBI) and its impact on the effectiveness of law enforcement and intelligence operations. Recognizing the demanding and high-stress nature of FBI work, this study delves into the significance of emotional intelligence in navigating complex situations, building strong relationships, and making sound decisions. The article highlights how emotional intelligence coaching not only benefits individual agents but also contributes to fostering a positive organizational culture within the FBI. Through a comprehensive analysis of the FBI's approach to emotional intelligence coaching, this study sheds light on the practical implications and outcomes of enhancing emotional intelligence in law enforcement agencies. The findings underscore the importance of emotional intelligence in promoting effective communication, conflict resolution, and decision-making skills, ultimately strengthening the FBI's mission to protect national security and uphold the law.
Additional file 1 of An analysis of age-standardized suicide rates in Muslim-majority countries in 2000-2019
Creators: name: Lew, Bob
name: Lester, David
name: Kõlves, Kairi
name: Yip, Paul S. F.
name: Chen, Ying-Yeh
name: Chen, Won Sun
name: Hasan, M. Tasdik
name: Koenig, Harold G.
name: Wang, Zhi Zhong
name: Fariduddin, Muhamad Nur
name: Zeyrek-Rios, Emek Yuce
name: Chan, Caryn Mei Hsien
name: Mustapha, Feisul
name: Fitriana, Mimi
name: Dolo, Housseini
name: Gönültaş, Burak M.
name: Dadfar, Mahboubeh
name: Davoudi, Mojtaba
name: Abdel-Khalek, Ahmed M.
name: Chan, Lai Fong
name: Siau, Ching Sin
name: Ibrahim, Norhayati
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Fig S1. Age-standardized suicide rate in Muslim-majority countries in 2000-2019 and comparison with the global average.
Additional file 3 of Health systems resilience in practice: a scoping review to identify strategies for building resilience
Creators: name: Forsgren, Lena
name: Tediosi, Fabrizio
name: Blanchet, Karl
name: Saulnier, Dell D
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 3: Table 4. All resilience strategies that were reported, within the identified thematic areas. List of all strategies identified in the paper, with thematic area, strategy, geographic area, scope of health system, and type of crisis.
Structural, optical and magnetic properties of nanostructured Cr-substituted Ni-Zn spinel ferrites synthesized by a microwave combustion method
Creators: name: El-Fadl, Abdulaziz Abu
name: Hassan, Azza M.
name: Kassem, Mohamed A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Nanoparticles of Cr3+-substituted Ni-Zn ferrites with a general formula Ni0.4Zn0.6-xCrxFe2O4 (x = 0.0 - 0.6) have been synthesized via a facile microwave combustion route. The crystalline phase has been characterized by XRD, TEM, FT-I and XPS revealing the spinel ferrite structure without extra phases. Crystallite sizes of 23 - 32 nm as estimated by XRD analyses, after corrections for crystal stains by Williamson-Hall method, are comparable to the average particle sizes observed by TEM which indicates successfully synthesized nanocrystals. Rietveld refinement analyses of the XRD patterns have inferred a monotonic decrease behavior of the lattice parameter with Cr doping in agreement with Vegard's law of solid solution series. Furthermore, cations distribution with an increased inversion factor indicate the B-site preference of Cr3+ ions. The oxidation states and cations distribution indicated by XPS results imply the Cr3+ doping on the account of Zn2+ ions and a partial reduction of Fe3+ to Fe2+ to keep the charge balance in a composition series of (Ni2+)0.4(Zn2+, Cr3+)0.6(Fe2+, Fe3+)2(O2-)4. The optical properties were explored by optical UV-Vis spectroscopy indicating allowed direct transitions with band gap energy that decreases from 3.9 eV to 3.7 eV with Cr doping. Furthermore, the photocatalytic activity for the degradation of methyl orange (MO) dye was investigated showing largely enhanced photodecomposition up to 30% of MO dye over Ni0.4Cr0.6Fe2O4 for 6 hours. A vibrating sample magnetometry (VSM) measurements at room temperature show further enhancement in the saturation magnetization of Ni0.4Zn0.6Fe2O4 , the highest in Ni-Zn ferrites, from about 60 to 70 emu/g with the increase of Cr concentration up to x = 0.1, while the coercivity shows a general increase in the whole range of Cr doping.
description: 21 page, 9 figures
Κατευθυντήριες οδηγίες χειρουργικής διαχείρισης των κακοηθειών του Θυρεοειδούς Αδένα στην Ελλάδα, μετά από ανασκόπηση της παγκόσμιας βιβλιογραφίας
Creators: name: Μποτάνη, Ιωάννα Σωτηρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Καρκίνος θυρεοειδούς
Χειρουργική διαχείριση
Πρωτόκολλα
Thyroid cancer
Surgical treatment
Guidelines

description: Σκοπός της εργασίας είναι η συλλογή, ταξινόμηση και επικαιροποίηση των διεθνών πρωτοκόλλων για την αντιμετώπιση του καρκίνου του θυρεοειδούς αδένα και η εναρμόνισή τους με τα ελληνικά δεδομένα, προκειμένου να προκύψουν κατευθυντήριες οδηγίες που συμβαδίζουν με την κοινή πρακτική στην Ελλάδα. Μελετήθηκαν οι επικαιροποιημένες διεθνείς οδηγίες από τις μεγαλύτερες χώρες και συγκρίθηκαν μεταξύ τους αλλά και με τα ελληνικά δεδομένα. Χωρίστηκαν σε κατηγορίες για την πιο εύκολη μελέτη και σύγκριση τους και αναλύθηκαν οι διαφορές και οι ομοιότητες. Οι κατευθυντήριες οδηγίες προκύπτουν απο μελέτες ετών και αναδιαμορφώνονται με την εξέλιξη της επιστήμης, με σκοπό να κατευθύνουν όσο καλύτερα γίνεται τους χειρουργούς στην σωστή εκτίμηση και αντιμετώπιση των ασθενών τους.
description: The purpose of this work is the collection, classification and updating of international protocols for the treatment of thyroid cancer and their harmonization with the Greek data, in order to emerge guidelines that are in line with common practice in Greece. The updated international directives from the largest countries were studied and compared between them and the Greek data. They were divided into categories for easier study and comparison and the differences and similarities were analyzed. The guidelines are the result of years of study and are being reformulated with the advancement of science, in order to better guide surgeons in the proper assessment and treatment of their patients.
An overview of public health measures in response to COVID-19 implemented by Indian states.
Creators: name: Dsouza, Vivek
Publisher: name: figshare
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 111712 Health Promotion
subject: 111709 Health Care Administration
subject: 160508 Health Policy
subject: FOS: Political science
subject: 111717 Primary Health Care

description: Objective: The table is a summary of state-specific public health measures (from Jan 04 – Apr 17) in response to the ongoing COVID-19 pandemic in India to understand how outcomes vary across Indian states. Since the lockdowns in India were implemented in a phased manner, we map the number of COVID-19 status on:- March 24, 2020: To understand the implementation strategies before lockdown phase 1.
- May 03, 2020 (end of phase 2): To understand implementation strategies during lockdown phase 1.
Methods:- Data regarding state-specific measures was taken from government and non-profit websites as well as widely published measures from online print media articles.(1) These are divided into two categories – measures before lockdown (Jan 4 – March 24) and till the end of lockdown phase 1 (March 25 – April 17).- Data regarding COVID-19 status (confirmed cases and deaths) is also taken from public websites.(2)- For state characteristics, we include indicators like Area, Population, and the number of districts
Observations: - Large states usually have more districts (UP: 75, MP: 51, Bihar: 38), but is not always a function of area and/or population. For instance, Andhra Pradesh is 7th largest state by area but has 13 districts.(3)
- States vary in their topography and political geography. For instance, most south Indian, east Indian states run from north to south, whereas north Indian states are evenly spread and run from east to west.- States also vary in terms their borders with neighboring states. UP shares borders with 9 states while Maharashtra and Karnataka (six states), MP and Rajasthan (five states).
This does not determine direct causality but does explain the varied conditions in which disease transmission occurs and how implementation strategies are different across Indian states.
References: (1) https://prsindia.org/covid-19/blogs / https://www.thehindu.com/news/national/india-coronavirus-lockdown-day-1-updates-march-25-2020/article31159466.ece(2) https://prsindia.org/covid-19/cases / https://www.covid19india.org/(3) https://indianexpress.com/article/explained/how-the-number-and-size-of-districts-vary-from-state-to-state-5908798/
A density theorem for the difference Galois groups of regular singular Mahler equations
Creators: name: Poulet, Marina
Publisher: name: arXiv
Year: 2020
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: The difference Galois theory of Mahler equations is an active research area. The present paper aims at developing the analytic aspects of this theory. We first attach a pair of connection matrices to any regular singular Mahler equation. We then show that these connection matrices can be used to produce a Zariski-dense subgroup of the difference Galois group of any regular singular Mahler equation.
Additional file 1 of Development and validation of the Japanese version of the Hyperarousal Scale
Creators: name: Ayabe, Naoko
name: Nakajima, Shun
name: Okajima, Isa
name: Inada, Ken
name: Yamadera, Wataru
name: Yamashita, Hidehisa
name: Tachimori, Hisateru
name: Kamei, Yuichi
name: Takeshima, Masahiro
name: Inoue, Yuichi
name: Mishima, Kazuo
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Additional file 1.
Non-diagonalizable and non-divergent susceptibility tensor in the Hamiltonian mean-field model with asymmetric momentum distributions
Creators: name: Yamaguchi, Yoshiyuki Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate response to an external magnetic field in the Hamiltonian mean-field model, which is a paradigmatic toy model of a ferromagnetic body and consists of plane rotators like the XY spins. Due to long-range interactions, the external field drives the system to a long-lasting quasistationary state before reaching thermal equilibrium, and the susceptibility tensor obtained in the quasista- tionary state is predicted by a linear response theory based on the Vlasov equation. For spatially homogeneous stable states, whose momentum distributions are asymmetric with zero-means, the theory reveals that the susceptibility tensor for an asymptotically constant external field is neither symmetric nor diagonalizable, and the predicted states are not stationary accordingly. Moreover, the tensor has no divergence even at the stability threshold. These theoretical findings are confirmed by direct numerical simulations of the Vlasov equation for the skew-normal distribution functions.
description: 10 pages, 8 figures
99. Neutrophil mediated T-cell suppression in ANCA vasculitis and Covid-19
Creators: name: Mhaonaigh1, Aisling Ui
name: Dwivedi1, Amrita
name: Makala Carroll1
name: Finlay1, Conor
name: Little1, Mark A
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: ANCA vasculitis (AAV) and Covid-19 (C-19) share many pathological characteristics including widespread endothelial dysfunction, a strong association with neutrophil activation with NETosis and a pro-thrombotic coagulation phenotype. We have previously defined a specific neutrophil fraction in AAV present in the PBMC layer of separated cells: Low Density Granulocytes (LDGs). We now hypothesise that these LDGs are also present in C-19 and sought to compare their phenotype with those present in AAV. Of particular interest is the expression of intracellular Arginase 1 (Arg-1), an enzyme linked to T cell suppression. Methods: LDGs were isolated using a modified percoll gradient preparation and analysed by traditional and imaging flow cytometry in patients with active and remission ANCA vasculitis, in those with severe moderate and mild C-19, and in healthy controls (HC). The phenotyping panel included CD14, CD15, CD16, CD10, CD33, CD62l. Intracellular Arg-1 was quantified following cellular permeabilisation. We then tested the effect of cultured neutrophil supernatants from C-19 of varying severity on T-cell proliferation and function. Results: We identified extensive LDG populations in both AAV and Covid-19 peripheral blood which were associated with disease severity. HC had uniformly high Arginase expression. We observed a distinct Arg-1 expression pattern in LDG populations from AAV and C-19. Intracellular Arg-1 levels were reduced in LDGs from patients with acute AAV; conversely, reduced Arg-1 expression was associated with mild disease in C-19. Using imaging flow cytometry, we observed that the intracellular distribution of Arg-1, which was distinctly granular in HC, was diffusely cytoplasmic in severe C-19 and virtually absent in mild C-19. Consistent with this, levels of Arg-1 in blood were elevated in mild disease and neutrophil supernatants from these patients more effectively inhibited t cell proliferation. Conclusion: LDGs are markedly elevated in both AAV and C-19, but their expression of Arg-1 and effect on T-cell function appears to be different. Our results suggest a block on Arg-1 release from LDGs in severe C-19, which may contribute to the observed hyper-inflammation in this condition. Disclosures: None Figure 1. Imaging Flow Cytometry highlights altered mature neutrophil Arg-1 expression in AAV, Covid 19 and healthy controls. Neutrophils were defined as CD15+ CD16+ singlets. Representative images of neutrophils shown.
MOESM1 of Characteristics and outcomes of antiretroviral-treated HIV-HBV co-infected patients in Canada?
Creators: name: Rana, Urvi
name: Driedger, Matt
name: Sereda, Paul
name: Shenyi Pan
name: Ding, Erin
name: Wong, Alex
name: Walmsley, Sharon
name: Klein, Marina
name: Kelly, Deborah
name: Loutfy, Mona
name: Rejean Thomas
name: Sanche, Stephen
name: Kroch, Abigail
name: Machouf, Nima
name: Marie-Helene Roy-Gagnon
name: Hogg, Robert
name: Cooper, Curtis
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Demographic characteristics participants by inclusion status (N = 10,447).
Necessary and sufficient condition for quantum state-independent contextuality
Creators: name: Cabello, Adan
name: Kleinmann, Matthias
name: Budroni, Costantino
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We solve the problem of whether a set of quantum tests reveals state-independent contextuality and use this result to identify the simplest set of the minimal dimension. We also show that identifying state-independent contextuality graphs [R. Ramanathan and P. Horodecki, Phys. Rev. Lett. 112, 040404 (2014)] is not sufficient for revealing state-independent contextuality.
description: 5 pages, 3 graphs
Additional file 2 of Development and validation of the Japanese version of the Hyperarousal Scale
Creators: name: Ayabe, Naoko
name: Nakajima, Shun
name: Okajima, Isa
name: Inada, Ken
name: Yamadera, Wataru
name: Yamashita, Hidehisa
name: Tachimori, Hisateru
name: Kamei, Yuichi
name: Takeshima, Masahiro
name: Inoue, Yuichi
name: Mishima, Kazuo
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Additional file 2.
Confronto tra LCA Edificio in Legno ed LCA Edificio in Laterocemento secondo UNI EN ISO 14040:2021
Creators: name: Gallian, Fabrizio
name: Piazza, Giacomo
Publisher: name: Zenodo
Year: 2022
Subjects: BIGWOOD INTERREG
timber constructions
multi-storey timber buildings
LCA
material technology
susatinability

description: Nei due report LCA (Life Cycle Assessment) dei due edifici, uno costruito mediante l’utilizzo del legno, e l’altro con il
 laterocemento, sono stati individuati i materiali, le fasi e le attività del ciclo di vita che maggiormente contribuiscono agli
 indicatori d’impatto riferiti ai servizi analizzati. Alcune variabili non sono modificabili direttamente ma è possibile
 identificare eventuali variabili che possano modificare i valori degli indicatori precedentemente misurati.
 Qui di seguito, si analizzano gli impatti della costruzione dell’edificio in laterocemento messi a confronto con gli impatti
 derivanti dalla costruzione dell’edificio con tecnologia in legno.