cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Museum of Unforeseen Circumstances
Creators: name: Ross, Ethan Forrest
Publisher: name: Old Dominion University Libraries
Year: 2018

description: On the day of his mother’s death, Charlie Agate abandons his current life and returns to his childhood home in Milwaukee, Wisconsin. For months, this new residency enables his thirst for isolation and comfort, but at last Charlie ventures back into the public world where he forms an unlikely bond with an elderly woman, Virginia Day. Virginia is strange and impoverished, broken and yet hopeful as she maintains an assertion so outlandish Charlie can’t help but pursue the truth of this mystery alongside her. This novella is about faith and mystery, guilt that leads to opportunity, and the persistence of charity unquenched by reward.
Additional file 2 of Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial
Creators: name: Huang, Qi-Fang
name: Zhang, Di
name: Luo, Yihong
name: Hu, Kun
name: Wu, Qiong
name: Qiu, Hailong
name: Xu, Fei
name: Wang, Mei-Ling
name: Chen, Xin
name: Li, Yan
name: Wang, Ji-Guang
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Table S1. Primary and secondary outcomes between treatment groups with generalized estimating equation analysis.
Locloud D1.2: Definition Of Metadata Schemas
Creators: name: Soroa, Aitor
name: Angelis, Stavros
name: Pardalis, Kostas
Publisher: name: Zenodo
Year: 2013
Subjects: Metadata Schemas "Europeana Data Model (EDM"

description: One of the LoCloud's main objectives is to ensure interoperability between the native metadata held by heritage organizations and the metadata used by Europeana. This deliverable describes the identification of the metadata schemas to be used within the project as intermediaries to Europeana Data Model (EDM), the schema introduced by Europeana to improve on ESE, its first data model.
description: LoCloud was funded by the European Commission's ICT Policy Support Programme. Grant Agreement number: 325099
title: Die Architektur von Anton & Josef Drexler in Wien
Creators: name: Kuttig, Robert Martin
Year: 2008

description: ABBILDUNGEN: nur in PRINTAUSGABE! -- In der zweiten Hälfte des 19. Jahrhunderts erfuhr Wien eine nachhaltige städtebauliche Erweiterung. Neue Stadtteile entstanden und existente Stadtteile wurden berichtigt. Die in jener Zeit geplanten und errichteten Bauwerke des Ateliers der Brüder Drexler prägen bis heute das Wiener Stadtbild. Die Hauptschaffenszeit von Anton und Josef Drexler in Wien währte zwischen 1887 und 1912. Die Bewahrung der originären Baukunst der Brüder Drexler ist heute gefährdet, weil ein Großteil der Objekte nicht unter Denkmalschutz ste-hen. Mitursache ist zweifellos die fehlende Aufarbeitung dieser Bauwerke. Unsachgemäße Dachausbauten und inadäquater Fenstertausch verursachen erheblichen Schaden. Die nichtvorhandene Beforschung und wenig gesicherte Dokumentation erschwert künftige Wiederherstellungsarbeiten erheblich bzw. macht sie vollständig unmöglich. Die in dieser Arbeit generierten Daten haben ihren Ursprung in dem von Anton Drexler erstellten Werkverzeichnis, in Urkunden und Briefen und weiteren Archivalien. Bauzeit-schriften der Jahrhundertwende und Unterlagen aus dem Planarchiv der MA 37 ergänzen die Begehung und Beforschung der Objekte vor Ort. In der vorliegenden Arbeit werden 37 Wiener Miet- und Geschäftshäuser, die von Anton und Josef Drexler geplant und errichtet wurden, analysiert und bewertet. Als Resultat lassen sich fünf stilistische Ausdrucksweisen isolieren, die die architektonische Diktion der Architekten Drexler auf dem Gebiet des Miet- und Geschäftshausbaues sichtbar machen: 1) Strenghistoristische Phase, 2) späthistoristische Phase, 3) sezessionisti-sche Phase, 4) spätsezessionistische Phase und 5) Phase des Reduktions-/Reformstils mit süddeutschen Heimatstilelementen. Künstlerisch haben die Drexler Brüder neben der innovativen Verarbeitung sezessionisti-scher Strömungen die moderne Strömung eines „Neubiedermeier“ zum Teil auf hohem baukünstlerischen Niveau umgesetzt. Technisch verwenden ihre Bauten die modernsten Baustoffe der Zeit. Die Grundrisse gehorchen einer stringenten und überlegten Rationali-tät. Die beachtliche Architektur ist auf die Ausbildung durch hervorragende Lehrer wie Theophil Hansen an der Akademie für Bildende Künste, auf den Einsatz raffinierter Detaillösungen des Kunsthandwerks der Wiener Werkstätte sowie auf die konsequente Auseinandersetzung mit und Integration von Elementen der Otto-Wagner-Schule zurückzuführen.
Additional file 3 of Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial
Creators: name: Huang, Qi-Fang
name: Zhang, Di
name: Luo, Yihong
name: Hu, Kun
name: Wu, Qiong
name: Qiu, Hailong
name: Xu, Fei
name: Wang, Mei-Ling
name: Chen, Xin
name: Li, Yan
name: Wang, Ji-Guang
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3: Table S2. Blood biochemistry measurements at baseline and 24 weeks (n=560).
sj-docx-1-jom-10.1177_01492063221117119 - Supplemental material for Burning up on Reentry: The Effect of Entrepreneurial Exit in the Hiring Context
Creators: name: Waddingham, Jacob A.
name: Zachary, Miles A.
name: Walker, H. Jack
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-docx-1-jom-10.1177_01492063221117119 for Burning up on Reentry: The Effect of Entrepreneurial Exit in the Hiring Context by Jacob A. Waddingham, Miles A. Zachary, and H. Jack Walker in Journal of Management
Additional file 4 of Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial
Creators: name: Huang, Qi-Fang
name: Zhang, Di
name: Luo, Yihong
name: Hu, Kun
name: Wu, Qiong
name: Qiu, Hailong
name: Xu, Fei
name: Wang, Mei-Ling
name: Chen, Xin
name: Li, Yan
name: Wang, Ji-Guang
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 4: Table S3. Least square mean changes from baseline to 24 weeks of follow-up and between-treatment differences (95% confidence interval) in blood biochemistry measurements (n=560).
Additional file 5 of Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial
Creators: name: Huang, Qi-Fang
name: Zhang, Di
name: Luo, Yihong
name: Hu, Kun
name: Wu, Qiong
name: Qiu, Hailong
name: Xu, Fei
name: Wang, Mei-Ling
name: Chen, Xin
name: Li, Yan
name: Wang, Ji-Guang
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 5. The participating hospitals.
A new specimen of Birgeria liui (Osteichthyes, Actinopterygii) from the Longobardian (Ladinian, Middle Triassic) of Xingyi, Guizhou Province, South China
Creators: name: Ni Peigang, Andrea Tintori
Publisher: name: Mahasarakham University
Year: 2017
Subjects: Birgeria liui, Actinopterygii, Middle Triassic, South China

description: Research & Knowledge, 3, 2
sj-docx-1-jet-10.1177_15266028221118507 – Supplemental material for Outcome Analysis From a Multicenter Registry on Unibody Stent-Graft System for the Treatment of Spontaneous Infrarenal Acute Aortic Syndrome (MURUSSIAS Registry)
Creators: name: Pecoraro, Felice
name: Volpe, Pietro
name: Boccalon, Luca
name: Migliara, Bruno
name: Rivolta, Nicola
name: Silvestro, Antonino
name: Trabattoni, Piero L. M.
name: Massara, Mafalda
name: Diaco, Domenico A.
name: Dinoto, Ettore
name: Urso, Francesca
name: Alberti, Antonino
name: Feriani, Giovanni
name: Franchin, Marco
name: Ravini, Matteo L.
name: Saccu, Claudio
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Cardiology
subject: Medicine
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-jet-10.1177_15266028221118507 for Outcome Analysis From a Multicenter Registry on Unibody Stent-Graft System for the Treatment of Spontaneous Infrarenal Acute Aortic Syndrome (MURUSSIAS Registry) by Felice Pecoraro, Pietro Volpe, Luca Boccalon, Bruno Migliara, Nicola Rivolta, Antonino Silvestro, Piero L. M. Trabattoni, Mafalda Massara, Domenico A. Diaco, Ettore Dinoto, Francesca Urso, Antonino Alberti, Giovanni Feriani, Marco Franchin, Matteo L. Ravini and Claudio Saccu in Journal of Endovascular Therapy
Sustainable Digital Transformation: Advancing Last-mile Connectivity and Edge Computing for Environmental, Social, and Economic Resilience
Creators: name: Chouchane, Hatem
name: Oosterwijk, Annabel
name: Ryan, Mark
Publisher: name: Zenodo
Year: 2025

description: In this technical paper, we provide examples of how digital infrastructure contributes to change and impacts

sustainable development, with a particular focus on its environmental, social, and economic implications. While

these technologies offer significant benefits, they also present challenges related to energy consumption, digital

inclusion, and long-term financial sustainability. Understanding these impacts is essential for ensuring equitable

and responsible deployment.
title: The nature of peer-feedback in a MOOC
title: a case study
titleType: Subtitle
Creators: name: Lopez Benavides, Denisse
Publisher: name: Lancaster University
Year: 2018

description: The present research study aimed to describe the nature of peer-feedback
      in a Massive Open Online Course (MOOC) offered by a German University. The
      MOOC was team-based, it offered the support of different actors, and
      allowed learners to participate in two different roles: students or
      supporters. Considering participants’ diversity and voluntary
      participation in the MOOC, three aspects of feedback were explored: 1) the
      quantity and quality of feedback provided throughout the course; 2) the
      feedback provided by students and supporters; and 3) the feedback provided
      by females and males in their roles as students and supporters. For this
      purpose, the method of content analysis and a regression model with a
      Poisson distribution were employed.

      Findings from the research study indicate a positive trend in the quantity
      of peer-feedback provided throughout the course, a constant use of those
      types of feedback expected to support the formative function of
      assessment, and an alternate use in other types of feedback identified as
      quality feedback. A statistically significant difference could be
      established between both roles. Supporters used a set of types of feedback
      more often than students. Finally, although no statistically significant
      differences could be established between both genders, differences could
      be established in relation to the types of feedback used in the role they
      had performed.

      The study concludes that the purpose and value of assessment were not
      threatened by the peer-feedback offered by its participants, despite their
      diversity and voluntary participation. Additionally, it recommends to
      present assessment criteria principally as a suggestion. Lastly, it
      encourages researchers on the field to inquire into a) mechanisms that
      motivate learners to engage in the voluntary activity of peer-assessment,
      thereby contributing to a sustainable participation throughout a complete
      course; and b) understanding participants’ commonalities, needs and
      expectations by analysing the feedback they provide.
Hamilton-Jacobi Treatment of Constraint Field Systems
Creators: name: Eshraim, Walaa I.
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: Motivated by the Hamilton$-$Jacobi approach of fields with constraints, we analyse the classical structure of three different constrained field systems: (i) the scalar field coupled to two flavors of fermions through Yukawa couplings (ii) the scalar field coupled minimally to the vector potential (iii) the electromagnetic field coupled to a spinor. The equations of motion are obtained as total differential equations in many variables. The integrability conditions are investigated. The second and third constrained systems are quantized using canonical path integral formulation based on the Hamilton$-$Jacobi treatment.
description: 18 pages
sj-pdf-3-jet-10.1177_15266028221119315 – Supplemental material for In Situ Laser Fenestration Technique: Bench-Testing of Aortic Endograft to Guide Clinical Practice
Creators: name: Grima, Matthew Joe
name: Wanhainen, Anders
name: Lindström, David
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Cardiology
subject: Medicine
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-3-jet-10.1177_15266028221119315 for In Situ Laser Fenestration Technique: Bench-Testing of Aortic Endograft to Guide Clinical Practice by Matthew Joe Grima, Anders Wanhainen and David Lindström in Journal of Endovascular Therapy
title: Untersuchungen zum Einfluss der Sportklettertätigkeit auf die Felsvegetation im subalpinen bis alpinen Umfeld
Creators: name: Klipp, Martin
Year: 2008

description: Kletterrouten sind die offensichtlichste Form der menschlichen Beeinflussung von Felsökosystemen. Ob und wie stark die Vegetation durch Klettern und insbesondere das Einrichten von Kletterrouten geschädigt wird, ist nach wie vor nicht eindeutig belegt. Um den Einfluss der Klettertätigkeit auf Gefäßpflanzen und Moose zu erheben, wurden im Zuge dieser Arbeit 90 kleinräumige Transekte in 3 verschiedenen Klettergärten in den Südtiroler Dolomiten untersucht. Die Vegetation der Klettergärten setzte sich vorwiegend aus Hemikryptophyten und Chamaephyten zusammen, wobei fast alle Arten aus den Klettergärten auch in der Felsvegetation der Umgebung vorkamen. Das Vorhandensein von Absätzen und Spalten erwies sich als wichtigster Einflussfaktor auf die Deckung, dabei konnte zwischen Arten unterschieden werden, die Absätze oder Spalten bevorzugten und solchen, die gleichermaßen auf Absätzen und Spalten anzutreffen waren. Die Entfernung von der Kletterroute zeigte, bei gleichzeitiger Kontrolle der mikrotopographischen Variabilität einen schwachen, nur teilweise signifikanten Einfluss auf die Deckung. Eine genaue Kontrolle der mikrotopographischen Variabilität erwies sich als unumgänglich für Arbeiten, die sich mit dem menschlichen Einfluss auf die Felsvegetation beschäftigen.
description: Climbing routes are the most visible examples of human influence on cliff ecosystems. Whether and to what extent the vegetation is negatively affected by climbing and, in particular, by climbing routes has not yet been clearly verified. In order to investigate the influence of recreational rock climbing on vascular plants and bryophytes, 90 transects in 3 different sport climbing areas in the South Tyrol Dolomites were investigated. The vegetation in the climbing areas consists predominantly of hemicryptophytes and chamaephytes and almost all species found in the climbing areas are also found in the cliff vegetation in the surrounding area. The presence of ledges and crevices proved to be the most important factor that influenced the vegetation cover. A distinction could be made between plant species that preferred either ledges or crevices and plant species that showed the same cover both on ledges and in crevices. When the microtopographic variability was considered, the distance from the climbing route showed little or no significant influence on the plant cover. A careful investigation of microtopographic variables is essential to any investigation of the influence of recreational rock climbing on cliff vegetation.
Additional file 1 of Interpretable artificial intelligence-based app assists inexperienced radiologists in diagnosing biliary atresia from sonographic gallbladder images
Creators: name: Zhou, Wenying
name: Ye, Zejun
name: Huang, Guangliang
name: Zhang, Xiaoer
name: Xu, Ming
name: Liu, Baoxian
name: Zhuang, Bowen
name: Tang, Zijian
name: Wang, Shan
name: Chen, Dan
name: Pan, Yunxiang
name: Xie, Xiaoyan
name: Wang, Ruixuan
name: Zhou, Luyao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Mental Health

description: Additional file 1: Method S1. Dataset Introduction. Method S2. Requirements for taking photos of smartphones. Method S3. Data pre-processing. Method S4. Model training. Method S5. Hospitals that provide videos to participate in clinical test. Method S6. Sample size calculation. Method S7. Sonographic gallbladder video acquisition requirements. Table S1. Device parameters used by 7 radiologists to take ultrasound gallbladder images with smartphones. Table S2. Device parameters used by 18 radiologists to take ultrasound gallbladder images with smartphones from 333 sonographic gallbladder videos. Table S3. Changes in the self-confidence of radiologists with different experiences in diagnosing biliary atresia with smartphone app’s assistance. Fig. S1. Different types of gallbladders on ultrasound. Fig. S2. The Confusion matrix results of the previous published model (a) and new model (b) on all external smartphone photo test data. Fig. S3. Example of a case where the new smartphone app helped confirm the radiologist’s diagnosis away from biliary atresia.
Attenuation of Type IV pili activity by natural products
Creators: name: Yalkut, Kerem
name: Hassine, Soumaya Ben Ali
name: Basaran, Esra
name: Kula, Ceyda
name: Ozcan, Aslıhan
name: Avci, Fatma Gizem
name: Keskin, Ozlem
name: Akbulut, Berna Sariyar
name: Ozbek, Pemra
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The virulence factor Type IV pili (T4P) are surface appendages used by the opportunistic pathogen Pseudomonas aeruginosa for twitching motility and adhesion in the environment and during infection. Additionally, the use of these appendages by P. aeruginosa for biofilm formation increases its virulence and drug resistance. Therefore, attenuation of the activity of T4P would be desirable to control P. aeruginosa infections. Here, a computational approach has been pursued to screen natural products that can be used for this purpose. PilB, the elongation ATPase of the T4P machinery in P. aeruginosa, has been selected as the target subunit and virtual screening of FDA-approved drugs has been conducted. Screening identified two natural compounds, ergoloid and irinotecan, as potential candidates for inhibiting this T4P-associated ATPase in P. aeruginosa. These candidate compounds underwent further rigorous evaluation through molecular dynamics (MD) simulations and then through in vitro twitching motility and biofilm inhibition assays. Notably, ergoloid emerged as a particularly promising candidate for weakening the T4P activity by inhibiting the elongation ATPases associated with T4P. This repurposing study paves the way for the timely discovery of antivirulence drugs as an alternative to classical antibiotic treatments to help combat infections caused by P. aeruginosa and related pathogens.
We Are the Bobcats
Creators: name: Mohan, Jacquelyn
Publisher: name: Old Dominion University Libraries
Year: 2018

description: We are the Bobcats is a novella that follows a group of high school seniors as they undergo the loss of two of their peers. Its central themes include grief, guilt, loss, and the complications between the three in the aftermath of tragedy. The story also concerns ideas of group identity, individualism, and the disparity between external presentation and internal struggles.
Synthesis of 4-sulfamoyl phenyl diazocarboxylic acid derivatives as novel non-classical inhibitors of human carbonic anhydrase II activity: an in vitro study
Creators: name: Bavandpour, Nima Fatahian
name: Mehrabi, Maryam
name: Adibi, Hadi
name: Mehrabi, Masomeh
name: Khodarahmi, Reza
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: The first class of carbonic anhydrase inhibitors (CAIs) discovered was sulfonamides, but their clinical use is limited due to side effects caused by their inhibition of multiple CA isoforms. To overcome this, researchers have focused on developing isoform-selective CAIs. This study involved the synthesis and characterization of novel carboxylic acid/sulfonamide derivatives. We investigated the interaction between these compounds and the human carbonic anhydrase II (hCA II) isoform using spectroscopic and computational methods. The synthesized compounds were evaluated based on their IC50, Kd and Ki values, and it was found that the inhibitory potency and binding affinity of the compounds increased with the number of carboxylic acids zinc binding groups. Specifically, the compound C4, with three carboxylic acid groups, showed the strongest inhibitory potency. Fluorescence measurements revealed that all compounds quenched the intrinsic fluorescence of hCA II through a dynamic quenching process, and each compound had one binding site in the hCA II structure. Thermodynamic analysis indicated hydrogen bonds and van der Waals interactions played key roles in the binding of these compounds to hCA II. Docking studies showed that the carboxylic acid groups directly attached to the zinc ion in the active site, displacing water/hydroxide ions and causing steric hindrance. Overall, the strengthening of inhibitory activity and the binding power of these carboxylic acid derivatives for the hCA II makes these compounds interesting for designing novel hCA II inhibitors.
The potential of some functional group compounds substituted 8-Manzamine A as RSK1 inhibitors: molecular docking and molecular dynamics simulations
Creators: name: Zayed, Ala’ Omar Hasan
name: Altarabeen, Mousa
name: AlShamaileh, Ehab
name: Zain, Sharifuddin Md
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Space Science
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Cancer, an incurable global disease, demands urgent anti-cancer drug development. Marine alkaloids like Manzamine and its derivatives show promise as RSK inhibitors against cancer cell invasion. Replacing the hydrogen at the 8-position of Manzamine A with a hydroxyl group has been shown to significantly enhance its biological activity. In this article, we designed various functional group compounds (A1–A21) substituted 8-Manzamine A by docking, MM-GBSA, molecular dynamics (MD) simulation, and well-tempered metadynamics (WT-MetaD) simulations to evaluate their potential as RSK1 inhibitors. Ligands A1–A21 were docked in the RSK1 N-terminal kinase domain (PDB ID: 2Z7Q) using the Glide module. The calculation of binding energy was performed using Prime MM-GB/SA, while MD simulations were conducted with the Desmond module of Schrodinger suite 2023. Compound A5 exhibits the highest G-score (−7.01) compared to 8-Hydroxymanzamine A (−6.08). Additionally, compounds A6, A10, A12, A17, A11, A4, and A13 demonstrate increased activity against RSK1 when compared to both 8-Hydroxymanzamine A and Manzamine A. Residues LEU68, VAL76, LEU141, PHE143, LEU144, PHE150, ASP148, GLU191, and LEU194 of RSK1 protein play a key role in binding with ligands. An MD simulation of Compound A5 was carried out to explore the dynamic interactions within the protein-ligand complex. Furthermore, WT-MetaD simulations validated the docking study results and identified the most energetically favored conformations for the A5/RSK1 complex. Ligands A5, A6, A10, A12, A17, A11, A4, and A13, featuring diverse functional groups and good Glide scores, may have the potential for significant RSK1 activity and merit further development. Functional group modifications at the 8-position of Manzamine A enhance its inhibitory activity against RSK1.Amine and carbonyl groups at position 8 of Manzamine A enhance its inhibitory activity, especially when accompanied by an aryl group.This research lays a solid groundwork for future drug development targeting RSK1, offering promising candidates for further investigation. Functional group modifications at the 8-position of Manzamine A enhance its inhibitory activity against RSK1. Amine and carbonyl groups at position 8 of Manzamine A enhance its inhibitory activity, especially when accompanied by an aryl group. This research lays a solid groundwork for future drug development targeting RSK1, offering promising candidates for further investigation.
Next-Gen Advocacy For Respiratory Health: Fun, Empowering, Participatory, Freely Adaptable
Creators: name: Balli, Fabio
name: Gervais, Yannick
name: Frangos, Maria
name: Gaudy, Thomas
name: Valderrama, Alena
name: Bransi, Myriam
name: Pache, Charles
name: Tse, Sze Man
Publisher: name: Zenodo
Year: 2018
Subjects: respiratory health promotion
games for health
asthma
mhealth
cyberhealth
serious games
free/libre and open source
participatory research
open science

description: Poster presented at the General Meeting of the Global Alliance against Respiratory Diseases in Helsinki. The topic of the conference was 'The Natural Step to Respiratory Health'.

	mHealth to better prevent and control respiratory diseases
	The example of asthma: a need for better pedagogy?
	BreathingGames.net
	Transforming health care into fun, rewarding experiences
	Testing the games locally: join forces!

Also watch the poster presented in 2017.
Additional file 6 of Interpretable artificial intelligence-based app assists inexperienced radiologists in diagnosing biliary atresia from sonographic gallbladder images
Creators: name: Zhou, Wenying
name: Ye, Zejun
name: Huang, Guangliang
name: Zhang, Xiaoer
name: Xu, Ming
name: Liu, Baoxian
name: Zhuang, Bowen
name: Tang, Zijian
name: Wang, Shan
name: Chen, Dan
name: Pan, Yunxiang
name: Xie, Xiaoyan
name: Wang, Ruixuan
name: Zhou, Luyao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Mental Health

description: Additional file 6. STARD 2015 Checklist.
Synthesis, characterization and larvicidal studies of ethyl 3-benzoyl-7-(piperidin-1-yl)indolizine-1-carboxylate analogues against Anopheles arabiensis and cheminformatics approaches
Creators: name: Shende, Sondarya Uttam
name: Al-Shar’i, Nizar A.
name: Saini, Surbhi Mahender
name: Mohanlall, Viresh
name: Gleiser, Raquel M.
name: Deb, Pran Kishore
name: Morsy, Mohamed A.
name: Venugopala, Katharigatta N.
name: Chandrashekharappa, Sandeep
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Medicine
Biotechnology
Chemical Sciences not elsewhere classified

description: According to WHO, in 2021, there was an estimation of 247 million malaria cases from 84 malaria-endemic countries. Globally an estimated count of 2 billion malaria cases and 11.7 million deaths due to malaria were recorded in the past two decades. Further, the emergence of drug-resistant mosquitos threatens mankind. Therefore, the development of newer larvicidal agents is the need of the hour. This research identifies a new series of variably substituted indolizines for their effectiveness in controlling Anopheles arabiensis larvae through larvicidal activity. The series of Ethyl 3-benzoyl-7-(piperidin-1-yl)indolizine-1-carboxylate analogues (4a-j) were synthesized by reacting 4-(piperidin-1-yl)pyridine, phenacyl bromides with ethyl propiolate via 1, 3-dipolar cycloaddition and the green metrics of the process are reported. All the newly synthesized compounds were characterized by spectroscopic techniques such as 1H NMR,13C NMR, FT-IR, and HRMS. The larvicidal effectiveness of the newly synthesized compounds was assessed against Anopheles arabiensis. Among the compounds studied, namely 4c, 4d, 4e, and 4f, displayed the most notable larval mortality rates within the series, reaching 73%, 81%, 76%, and 71% respectively, in contrast with the negative control acetone. In comparison, the standard Temephos exhibited a mortality rate of 99% at the same concentration. Furthermore, computational approaches including molecular docking and molecular dynamics simulations identified the potential targets of the series compounds as the larval Acetylcholinesterase (AChE) enzyme and the Sterol Carrier Protein-2 (SCP-2) protein. However, it is essential for these computational predictions to undergo experimental validation.
Additional file 1 of Identifying the most at-risk age-group and longitudinal trends of drug allergy labeling amongst 7.3 million individuals in Hong Kong
Creators: name: Chiang, Valerie
name: Kan, Andy Ka Chun
name: Saha, Chinmoy
name: Au, Elaine Y. L.
name: Li, Philip H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Hematology
subject: Virology
subject: Computational Biology

description: Additional file 1: Text S1. Drugs which did not fit into any drug classes and categorized as “Others”.
title: Maximilian II. und sein Sohn Rudolf II.
Creators: name: Dworak, Sabine
Year: 2008

description: Der Autor Andreas Edel formulierte drei Arten von Toleranz in Zusammenhang mit den Beweggründen für herrschaftliches Verhalten. Neben der unbedingt gewährten Toleranz, hinter der ein bewusstes Verhindern von Diskriminierung Andersgläubiger im Rechtssystem steckt, existieren die bedingte Toleranz und die Zwecktoleranz. Während die Zwecktoleranz nur ausgeübt wird, um eine wichtigere politische Absicht zu verfolgen, findet die bedingte Toleranz dort statt, wo man helfen kann, ohne das innere Gleichgewicht und damit den Frieden zu zerstören. Wendet man dies auf die beiden Kaiser an, dann ergibt sich die Frage, ob es nur eine Zwecktoleranz, eine durch äußere Gegebenheiten verlangte Toleranz, war, die die beiden verfolgten oder ob mehr dahinter steckte. Bei Maximilian war es definitiv mehr als eine nur durch äußere Umstände gesteuerte Toleranz, weil er sich intensiv mit den Glaubensgrundsätzen der Reformatoren beschäftigte. Dies schien Grund genug zu sein, dass er einer ihm sympathischen Bewegung mehr Freiheiten zugestand und eine echte Toleranz walten ließ, die nicht nur auf Rücksichtnahme basierte. Dennoch war auch er nicht frei von Zwängen. Den Papst und die Kirche so vor den Kopf zu stoßen, dass sie sich vielleicht ganz von ihm abwandten, traute er sich schon allein wegen des Gleichgewichtes der Konfessionen und der damit verbundenen Sicherheit innerhalb des Reiches nicht. Auch Rudolf, wenn auch in wesentlich geringerem Ausmaß als Maximilian, akzeptierte den Protestantismus in seiner direkten Umgebung. Bei ihm hat man viel mehr den Eindruck, dass er Wissenschaft und Kunst höher ansiedelte als die Zugehörigkeit zu einer Glaubensgemeinschaft. Beiden gemeinsam war aber, dass sie mehr Getriebene als Treibende waren. Getrieben nämlich von der politischen Konstellation des Jahrhunderts, das beherrscht war von Glaubensfragen und von der drohenden Invasion der Osmanen. Dazu kam die Tatsache, dass mächtige Kurfürsten der protestantischen Bewegung angehörten und eine ernsthafte Auseinandersetzung mit ihnen aufgrund reiner Glaubensfragen den Frieden im gesamten Reich gefährdet hätte.
Light-matter interactions in layered materials and heterostructures: from moiré physics and magneto-optical effects to ultrafast dynamics and hybrid meta-photonics
Creators: name: Sortino, Luca
name: Guimarães, Marcos H. D.
name: Molina-Sánchez, Alejandro
name: Quan, Jiamin
name: Garoli, Denis
name: Maccaferri, Nicolò
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Layered two-dimensional (2D) materials have revolutionized how we approach light-matter interactions, offering unprecedented optical and electronic properties with the potential for vertical heterostructures and manipulation of spin-valley degrees of freedom. The discovery of moiré physics in twisted heterostructures has further unlocked new possibilities for controlling the band structure of tailored semiconductor heterostructures. In parallel, the integration of 2D materials with hybrid photonic structures and ultrafast studies on their optical and spin-valley properties has revealed a wealth of novel physical phenomena. This perspective highlights the recent advances in our understanding of light-matter interactions in moiré and 2D systems, with a particular emphasis on ultrafast processes and the integration of these materials into photonic platforms. We explore the implications for optoelectronics and emerging photonic technologies, positioning 2D materials as a transformative tool for next-generation devices.
Additional file 2 of Identifying the most at-risk age-group and longitudinal trends of drug allergy labeling amongst 7.3 million individuals in Hong Kong
Creators: name: Chiang, Valerie
name: Kan, Andy Ka Chun
name: Saha, Chinmoy
name: Au, Elaine Y. L.
name: Li, Philip H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Hematology
subject: Virology
subject: Computational Biology

description: Additional file 2: Table S1. Analysis of the annual incidence of drug allergy labels from 2016 to 2020 using negative binomial regression.
Structural and Spectroscopic Investigation of Nanomorphology in Bulk Heterojunction Organic Solar Cells
Creators: name: Bothra, Urvashi
Publisher: name: Monash University
Year: 2023
Subjects: classificationCode: 401608
subject: Organic semiconductors
classificationCode: 401605
subject: Functional materials

description: This thesis focuses on organic solar cells (OSCs) which are photovoltaic devices where the active layer is based on organic semiconductors. OSCs have recently demonstrated a record efficiency of over 19% and offer advantages such as easy processing, semitransparency, and flexibility. Niche applications include building integrated photovoltaics and indoor photovoltaics. The efficiency of OSCs is highly dependent on the bulk heterojunction (BHJ) morphology, which is formed by mixing organic semiconducting materials and is easily modulated by varying processing parameters. Here, the BHJ morphology is visualized by various structural and spectroscopic techniques to understand the structure-function relationship and improve OSC performance.
sj-pdf-2-mdm-10.1177_0272989X221117162 – Supplemental material for Validating the Assumptions of Population Adjustment: Application of Multilevel Network Meta-regression to a Network of Treatments for Plaque Psoriasis
Creators: name: Phillippo, David M.
name: Dias, Sofia
name: Ades, A. E.
name: Belger, Mark
name: Brnabic, Alan
name: Saure, Daniel
name: Schymura, Yves
name: Welton, Nicky J.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-2-mdm-10.1177_0272989X221117162 for Validating the Assumptions of Population Adjustment: Application of Multilevel Network Meta-regression to a Network of Treatments for Plaque Psoriasis by David M. Phillippo, Sofia Dias, A. E. Ades, Mark Belger, Alan Brnabic, Daniel Saure, Yves Schymura and Nicky J. Welton in Medical Decision Making
title: Chinesischer Realismus
Creators: name: Mayrhofer, Kerstin
Year: 2008

description: Die vorliegende Diplomarbeit behandelt sechs zeitgenössische chinesische KünstlerInnen: Fang Lijun, Yu Hong, Liu Xiaodong, Zhang Yuan, Wang Xiaoshuai und Jia Zhangke, die nach dem Kriterium der Interaktion und Inbezugnahme von Malerei und Film ausgewählt wurden. Eine intensive Recherche ihrer Biografie führte zu dem Ergebnis, dass ab dem Zeitpunkt ihres Eintritts in die Kunstakademie in Peking, ein reger Austausch zwischen den KünstlerInnen stattfand. Wichtige Gemeinsamkeiten dieser KünstlerInnen sind, dass sie in den 1960er Jahren - in den Wirren der Kulturrevolution - geboren wurden und nach dem Massaker am 4. Juni 1989 in Peking ihren Abschluss gemacht haben. Ein weiteres Verbindungselement dieser KünstlerInnen ist, dass ihr eigenständiges künstlerisches Schaffen in einer Zeit des sozialen, politischen und wirtschaftlichen Umbruchs in China einsetzte und sie dem Aufkommen dieses „neuen Lebensgefühls“ nachspürten und als Themen in ihrer Kunst aufgriffen. Dabei konnte festgestellt werden, dass die hier vorgestellten KünstlerInnen in der Bildtradition des „Sozialistischen Realismus“ arbeiten. Im Zuge dessen wurde dem Ursprung und der Bedeutung dieses in China für eine lange Zeit einzig tolerierten Stils nachgegangen. Ausgehenden von ihren künstlerischen Arbeiten, die den Mensch ins Zentrum ihrer Betrachtung rücken, werden die Auswirkungen der voranschreitenden Modernisierung und der dadurch einhergehenden Probleme in China aufgezeigt.
Additional file 1 of Associations between the artificial intelligence scoring system and live birth outcomes in preimplantation genetic testing for aneuploidy cycles
Creators: name: Lee, Chun-I
name: Huang, Chun-Chia
name: Lee, Tsung-Hsien
name: Chen, Hsiu-Hui
name: Cheng, En-Hui
name: Lin, Pin-Yao
name: Yu, Tzu-Ning
name: Chen, Chung-I
name: Chen, Chien-Hong
name: Lee, Maw-Sheng
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 1
Research Data for Portsite metastasis of adenocarcinoma after laparoscopic cholecystectomy with an unknown primary tumor: a case report
Creators: name: Lu, Jun
name: Zhou, Weijiang
name: Zhou, Lixin
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Research Data for Portsite metastasis of adenocarcinoma after laparoscopic cholecystectomy with an unknown primary tumor: a case report by Jun Lu, Weijiang Zhou and Lixin Zhou in Journal of International Medical Research
Supplemental Material - The Affordance Directive: Affordance Priming Facilitates Object Detection Similar to Semantic Priming
Creators: name: Surber, Tyler
name: Huff, Mark J.
name: Hajnal, Alen
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material for The Affordance Directive: Affordance Priming Facilitates Object Detection Similar to Semantic Priming by Tyler Surber, Mark J. Huff and Alen Hajnal in Psychological Reports
title: Cernite robertum regem virtute refertum
Creators: name: Cerepak, Susanne
Year: 2008

description: Die Barockisierung von S. Chiara in Neapel wurde 1742 unter der Leitung Domenico Antonio Vaccaros begonnen und war 1763 vollendet. Die Eingriffe führten zu einer radikalen Verwandlung des schlichten gotischen Innenraumes in ein prachtvolles und bald kritisiertes Ambiente. Während des zweiten Weltkriegs fiel dieses seiner vollständigen Zerstörung zum Opfer. Basierend auf vereinzelten Fotos und dem gut erforschten Quellenmaterial will die vorliegende Arbeit v.a. den Umgang des Settecento mit dem Erbe des Mittelalters beleuchten und zunächst folgende Fragen stellen: Warum wurde die Barocksierung so spät überhaupt noch in Auftrag gegeben? Führte die Komplettverhüllung des robertinischen Kircheninneren tatsächlich zu einem Bruch mit der eigenen Vergangenheit? Oder konnten sich in der neuen Ausstattung über den ästhetischen Anspruch hinaus auch bestimmte Traditions- und Institutionsvorstellungen manifestieren? Weil die Beantwortung dieser offenen Punkte nur durch eine epochenübergreifende Zusammenschau von gotischem und barocken Bestand möglich ist, werden zunächst die Eigenheiten der mittelalterlichen Kirche und die Vorraussetzungen für die Renovierung analysiert. Es folgt eine Untersuchung der ikonologischen und formalen Merkmale des Barockinterieurs. Der anschließende Vergleich mit dem Bedeutungsspektrum des Gründungsbaues zeigt auf, welch großen Respekt vor dem legendären Gründer alle ikonographischen Details der Dekoration und ihr ästhetisches Instrumentarium widerspiegeln. Dass das Streben nach Kontinuität, der Gedanke an König Robert und eine zeitgemäße Religiosität den medialen Gehalt des neuen Programms entscheidend geprägt haben, führt zuletzt zur Betrachtung der Lebenswelt der Klarissen und zur Frage nach dem Spiritus rector der gesamten Inszenierung. Ziel ist, das barocke Interludium S. Chiaras anhand der ausgewählten Aspekte zu rehabilitieren und neu zu bewerten.
Computational investigation on the conformational dynamics of C-terminal truncated α-synuclein bound to membrane
Creators: name: Das, Dorothy
name: Mattaparthi, Venkata Satish Kumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Neuroscience
Chemical Sciences not elsewhere classified
Cancer
Computational Biology

description: Accelerated progression rates in Parkinson’s disease (PD) have been linked to C-terminal domain (CTD) truncations of monomeric α-Synuclein (α-Syn), which have been suggested to increase amyloid aggregation in vivo and in vitro. In the brain of PD patients, CTD truncated α-Syn was found to have lower cell viability and tends to increase in the formation of fibrils. The CTD of α-Syn acts as a guard for regulating the normal functioning of α-Syn. The absence of the CTD may allow the N-terminal of α-Syn to interact with the membrane thereby affecting the normal functioning of α-Syn, and all of which will affect the etiology of PD. In this study, the conformational dynamics of CTD truncated α-Syn (1–99 and 1–108) monomers and their effect on the protein–membrane interactions were demonstrated using the all-atom molecular dynamics (MD) simulation method. From the MD analyses, it was noticed that among the two truncated monomers, α-Syn (1–108) was found to be more stable, shows rigidness at the N-terminal region and contains a significant number of intermolecular hydrogen bonds between the non-amyloid β-component (NAC) region and membrane, and lesser number of extended strands. Further, the bending angle in the N-terminal domain was found to be lesser in the α-Syn (1–108) in comparison with the α-Syn (1–99). Our findings suggest that the truncation on the CTD of α-Syn affects its interaction with the membrane and subsequently has an impact on the aggregation.
Additional file 1 of Genomic data integration tutorial, a plant case study
Creators: name: Mardoc, Emile
name: Sow, Mamadou Dia
name: Déjean, Sébastien
name: Salse, Jérôme
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. Histograms of methylomics and transcriptomics’ logged distributions from one poplar (Adour) population. Supplementary Figure 2. Omics data integration with cimDiablo_v2. Supplementary Figure 3. Boxplots of k cluster groups in each poplar population for gene expression and methylation. Supplementary Figure 4. Comparison between 'non-denoised' and 'denoised' data for methylation in gene-body and promoter for CG, CHG and CHH contexts.
Additional file 1 of How does hospital organisation influence the use of caesarean sections in low- and middle-income countries? A cross-sectional survey in Argentina, Burkina Faso, Thailand and Vietnam for the QUALI-DEC project
Creators: name: Etcheverry, Camille
name: Betrán, Ana Pilar
name: de Loenzien, Myriam
name: Robson, Michael
name: Kaboré, Charles
name: Lumbiganon, Pisake
name: Carroli, Guillermo
name: Mac, Quoc Nhu Hung
name: Gialdini, Celina
name: Dumont, Alexandre
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary information Table S1. Pre-defined list used to collect indication for CS (Quali-Dec post-partum survey).