cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Role of CD8+ T Cell Phenotype and Cytotoxicity on Cancer Immunotherapy
Creators: name: Stark, Felicity
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Cancer
Vaccine
CD8
T cell
Archaeosomes
Listeria
Salmonella
Immunotherapy

description: Cancer vaccines can fail despite the induction of large numbers of CD8+ T cells. Two categories of memory CD8+ T cells have been defined; central memory (TCM, IL-7RαhighCD44highCD62Lhigh) and effector memory (TEM, IL-7RαhighCD44highCD62Llow). It is clear that the memory phenotype of CD8+ T cells can affect vaccine potential; however methods to augment a beneficial phenotype are not clear. I have compared three vaccine delivery systems: Listeria monocytogenes, Salmonella enterica serovar Typhimurium and the particulate liposomal adjuvant, archaeosomes, for their efficacy to protect against murine melanoma. My study revealed that the anti-tumour response is strongly influenced by the kinetics, phenotype, and lymph node homing potential of CD8+ T cells. Listeria monocytogenes-ovalbumin (LM-OVA) induced TCM cells were adept at long lasting protection against B16-OVA melanoma due to their increased homeostatic and antigen-induced proliferation, interleukin-2 production, and ability to extravasate into tumour draining lymph nodes. Conversely, although Salmonella Typhimurium-ovalbumin (ST-OVA) induced TEM, produced IFN-γ, and killed target cells, this was insufficient for long-term tumour protection. Selectin-ligand engagements of TCM cells influenced their homing potential and efficacy against murine melanoma. Fucosyltransferase deficient (FtDKO) mice, lacking functional selectin ligands, were vaccinated with LM-OVA; despite the activation of cytotoxic CD8+ T cells, there was a reduced protection against murine melanoma compared to wild-type. FtDKO CD8+ T cells exhibited reduced extravasation into FtDKO lymph nodes compared to wild-type. Additionally, fewer FtDKO CD8+ T cells compared to wild-type migrated into tumour sites. Archaeosome vaccination was used to compare the influence of CD8+ T cell quantity versus phenotype. Single or multiple therapeutic vaccinations with archaeosome-OVA yielded transient melanoma tumour protection, despite an increased frequency of circulating and tumour infiltrating CD8+ T cells. This correlated with increased expression of Program death receptor-1 (PD-1) on CD8+ T cells and induction of regulatory T cells. Prophylactic archaeosome-OVA vaccination resulted in a maximal frequency of antigen-specific CD8+ T cells of ~50-60 % with just three injections, and ~50 % of the mice were of mice were afforded long-term tumour protection (> 90 days). Overall, my study shows that the choice of vaccine adjuvant and/or vector can profoundly influence CD8+ T cell quality and cancer vaccine efficacy.
Evaluation of Antimicrobial Activity of Calotropis Species
Creators: name: Shaikh AS*
name: Dr. Abubakar B
name: Dr.Barrawaz AY
name: Sayyed SK
Publisher: name: Zenodo
Year: 2024

description: Abstract

Calotropis (Asclepiadaceae) often known as “madar” is an important medicinal plant. The current investigation includes the Phytochemical and Antimicrobial study of Calotropis species.

Solvent such as methanol, butanol, acetone, pet ether, chloroform and water were used. The antimicrobial study executed by agar well diffusion technique.

Alkaloids, flavonoids, tannins, saponins, phenols, and terpenoids are found in both plants according to phytochemical study. For antibacterial investigation Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa were used. The susceptibility of bacterial strains against different solvent extracts was tested using the agar well diffusion method.

butanol and methanol extracts have better antibacterial activity than other extract because their zones of inhibition are larger.

Keywords: Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Agar well diffusion method, etc.
Resveratrol as a Novel Therapeutic Agent for Treating Duchenne Muscular Dystrophy
Creators: name: Burt, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: resveratrol
skeletal muscle
utrophin
dystrophin
mdx
duchenne muscular dystropy
slow oxidative myogenic program
sirt1
pgc-1 alpha

description: Duchenne Muscular Dystrophy (DMD) is an x-linked neuromuscular disease that is caused by an absence of dystrophin protein, rendering skeletal muscle more susceptible to contraction-induced damage. One therapeutic strategy focuses on increasing the expression of endogenous utrophin A, a dystrophin homologue. Interestingly, slow muscle is more resistant to the dystrophic pathology and has increased utrophin A expression (Webster 1998; Gramolini 2001b). These observations led researchers to explore the therapeutic potential of stimulating the slow, oxidative myogenic program (SOMP) in the mdx context. Beneficial adaptations were seen with pharmacological activation of PPARδ and AMPK. We treated mdx mice with resveratrol (~100mg/kg/day), a putative SIRT1 activator, for 6-7 weeks and evaluated the activity of phenotypic modifiers that are known to influence the SOMP. SIRT1 activity and protein levels increased significantly, as well as downstream PGC-1α activity. There was evidence of a fibre type conversion as the treated mice had a higher proportion of the slow myosin heavy chain isoforms in both the EDL and Soleus skeletal muscles. Utrophin A protein levels showed modest, but consistent increases with resveratrol treatment. Finally, histological analysis revealed improvements in central nucleation and fibre size variability. These findings were promising, but raised the question of whether modifying the treatment regimen may result in greater therapeutic benefits. Surprisingly, we discovered that an elevated dose of 500mg/kg/day was ineffective in its promotion of the SOMP. SIRT1 was not activated and there was no change in utrophin A levels with resveratrol treatment. Taken together, this study demonstrates that resveratrol has the ability to promote the SOMP through SIRT1 and PGC-1α activation. It also highlights the importance of selecting an appropriate dose of resveratrol to maximize its effectiveness.
Repurposing 13-Cis-Retinoic Acid: A Potential Treatment for Aneurysms-Osteoarthritis Syndrome
Creators: name: Putos, Samantha
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Loeys-Dietz Syndrome Type 3
Aneurysms-Osteoarthritis Syndrome
SMAD3
13-cis-retinoic acid
Isotretinoin
Care for Rare
TGF-beta

description: Approximately 7000 rare disorders exist, affecting 2 percent of Canadians and millions of people worldwide. Given that for many rare diseases only one allele is mutated, we hypothesize inducing expression of the remaining wild-type allele may have a therapeutic effect. SMAD3 heterozygosity results in Aneurysms-Osteoarthritis Syndrome (AOS) – an aortic aneurysm disorder also known as Loeys-Dietz Syndrome Type 3. We conducted a screen of FDA-approved compounds and found that 13-cis-retinoic acid (13-CRA) induces SMAD3 in normal human fibroblast cultures. Treatment with therapeutic concentrations of 13-CRA increased SMAD3 mRNA in normal human fibroblasts, patient fibroblasts, wild-type murine vascular smooth muscle cells and Smad3+/- murine vascular smooth muscle cells. Increases in SMAD3 protein were also observed in normal human fibroblasts, patient fibroblasts, and wild-type murine vascular smooth muscle cells. Immunofluorescent imaging revealed the primary site of protein induction to be nuclear. We report here the in vitro induction of SMAD3 mRNA and protein by therapeutic levels of 13-CRA and suggest further investigation of this modality for the treatment of AOS.
Preparation and Characterization of TiO2-Based Nano Particles and Tests for Their Activities in Meth¬ylene Blue Photodegradation
Creators: name: Duan, Aoshu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: photocatalyst
TiO2

description: A two-step hydrothermal method was applied to synthesis Vanadium Sulfide (IV) coupled with commercial P25 on TiO2 nanoparticle (VS4-on-P25). Materials were characterized by scanning electron microscope (SEM), high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV-Vis), diffuse reflectance UV-Vis spectroscopy and Raman spectroscopy. Photocatalytic activity of this new material was determined by photo-degradation of Methylene blue (MB) under UV irradiation. Experiments show that the VS4-on-P25 exhibits a higher photocatalytic activity than commercial P25 by providing more active site for dye adsorption, and reducing the recombination of charge carriers. Furthermore, the VS4-on-P25 extends its light-absorption spectrum into visible-light range due to its narrower band gap. The highest photocatalytic activity was found with a VS4 loading of 6 wt.%, which outperforms pure P25 by a factor of 2.29 in MB degradation rate.
Accounts of PR Practices and Challenges by Senior Managers: A Qualitative Exploratory Study
Creators: name: Sheriko, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: small nonprofit organizations
public relations
case study
excellence
qualitative interviews

description: Small nonprofit organizations are faced with limited resources and budgets for setting and reaching their goals. Some are nevertheless able to mitigate these challenges and achieve success. This thesis examines how this can be done. Organizations with excellent public relations programs have been found to be successful in achieving their goals (Grunig et al., 2002). Through the lens of the excellence model, this thesis analyzes, using in depth, semi-structured interview data, how senior managers of seven successful small nonprofits account for their success and address challenges as well as how their practices reflect the excellence model. This thesis does not test the excellence model in the context of small nonprofits, but rather attempts to establish recommendations for communication and PR success for small nonprofits based on what is learned from a small group of successful organizations.
Legal Book Collecting in Late Medieval Bristol: The Case of Harvard, Houghton Library, MS Richardson 40
Creators: name: Lahey, Stephanie Jane
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Medieval
Statuta Angliae
Manuscript
Legal History
Bristol, UK
Book History

description: From the late-thirteenth through late-fifteenth centuries, among the most frequently produced and widely disseminated books in England were unofficial, common law statute-based miscellanies known as Statuta Angliæ or ‘statute books’. In ca. 1470, a large format, de luxe, yet highly standardized, version of this codicological genre emerged; likely produced on a speculative basis, it survives in approximately two dozen exemplars. This thesis takes as its focus a member of this latter group: Cambridge, MA, Harvard University, Houghton Library, MS Richardson 40 (ca. 1460– 70). After reviewing current scholarship on these codices—examining several key issues and clarifying previous descriptions to enhance our understanding—it endeavours to establish a likely provenance for MS Richardson 40, exploring the ways in which both the manuscript and the broader genre resonate with the life of the proposed patron, Philip Mede (d. 1476), merchant, twice MP, and thrice Mayor of Bristol.
EWS_of_Infectious_diseases_SI from An early warning indicator trained on stochastic disease-spreading models with different noises
Creators: name: Chakraborty, Amit K. K.
name: Gao, Shan
name: Miry, Reza
name: Ramazi, Pouria
name: Greiner, Russell
name: Lewis, Mark
name: Wang, Hao
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified

description: Supplementary figures
Nitrogen Dynamics Following Incorporation of 3-Year Old Grassland Set-Asides in the Fraser River Delta of British Columbia
Creators: name: Walji, Khalil
name: Krzic, Maja, 1963-
name: Bondar, Drew
name: Smukler, Sean
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Short-term grassland set-asides (GLSA) have been incorporated into intensive annual crop rotations to improve soil quality. The legacy of the GLSA to subsequent annual crops, however, is not well understood. The objective of this study was to determine the impacts of 3-year-old GLSA on nitrogen (N) dynamics and the yield of the subsequent cash crop. A regional analysis was conducted over two years, utilizing eight production fields transitioning from GLSA, paired with fields in continuous annual crop rotation (ACR) with matching management. A controlled plot-scale experiment was also conducted on a single 3-year-old GLSA, comparing fertilizer types, rates, and timing of incorporation. In each experiment, soils were sampled every 10–14 days for ammonium (NH₄⁺-N) and nitrate (NO₃⁻-N), along with ion probes, installed near the rooting zone to track plant available nitrogen (PAN) throughout the season. The results from the regional analysis are confounding, in 2015 showing that GLSA supplied an additional 18 kg PAN ha⁻¹ compared to ACR but showed no PAN benefits in 2016. The controlled plot-scale experiment highlighted the importance of fertilizer type to subsequent PAN, showing synthetic treatments consistently supplied more PAN than organic. The results from this study suggest that 3-year-old GLSAs can potentially improve PAN to subsequent crops depending on how they are managed.
Supplementary document for Edge-dependent photogalvanic effect in 1T′-ReS2-based polarized self-powered photodetectors - 7231779.pdf
Creators: name: Ge, Meng
name: Xu, Degao
name: Tan, Jianing
name: Ouyang, Gang
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Band structures of 1T'-ReS2 monolayer, and the edge states of AC NR and ZZ NR, as well as the photocurrents of AC NR, ZZA NR, ZZB NR and 5-L ZZA/B and 1T'-ReS2 monolayer device.
Wartime Training at Canadian Universities during the Second World War
Creators: name: Millar, Anne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Canada
universities
Second World War
military training
higher education
military
armed forces
students
COTC
Canadian Officers Training Corps
mobilization
veteran
NCCU
national conference of canadian universities

description: This dissertation provides an account of the contributions of Canadian universities to the Second World War. It examines the deliberations and negotiations of university, government, and military officials on how best to utilize and direct the resources of Canadian institutions of higher learning towards the prosecution of the war and postwar reconstruction. During the Second World War, university leaders worked with the Dominion Government and high-ranking military officials to establish comprehensive training programs on campuses across the country. These programs were designed to produce service personnel, provide skilled labour for essential war and civilian industries, impart specialized and technical knowledge to enlisted service members, and educate returning veterans. University administrators actively participated in the formation and expansion of these training initiatives and lobbied the government for adequate funding to ensure the success of their efforts. This study shows that university heads, deans, and prominent faculty members eagerly collaborated with both the government and the military to ensure that their institutions’ material and human resources were best directed in support of the war effort and that, in contrast to the First World War, skilled graduates would not be heedlessly wasted. At the center of these negotiations was the National Conference of Canadian Universities, a body consisting of heads of universities and colleges from across the country. This organization maintained an active presence in all major deliberations and exercised substantial influence over the policies affecting the mobilization of university resources.
Predicting sporting outcomes: a statistical approach
Creators: name: Bailey, Michael J.
Publisher: name: Swinburne
Year: 2024

description: The aim of this thesis is to establish a consistent statistical approach to aid in the prediction of sporting outcomes. This process has been achieved by considering six differing outcomes relating to both AFL football and cricket that cover aspects of team performance, individual performance and other associated match outcomes. The advent of the Internet has created a wealth of electronic data that has facilitated the use of particularly large datasets to identify historical features that could independently explain statistically significant portions of variation associated with an outcome. Multivariate modelling was used to weight the contributing effects of each significant variable and produce prediction equations that, when applied to holdout samples, could determine the predictability of the outcome and the predictive capacity of the chosen approach. Predicted outcomes were converted into probabilities and where betting markets were present, the efficiency of the corresponding market was determined. Where wagering markets were not in existence, this process can be seen to establish benchmarks for future reference. While undisputable evidence exists to the inefficiency of price setting techniques currently employed by Australian bookmakers, the process of using past data to aid in the prediction of sporting events can be seen to have benefits for both punters and bookmakers alike. While punters can use such techniques to exploit market efficiencies in the short term, the objectivity and speed provided by a computer driven process will undoubtedly replace the more traditional methods of price setting currently incorporated by bookmakers.
The Role of OPA1 and Interacting Proteins in Mitochondrial Function
Creators: name: Patten, David A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: OPA1
SLC25A
CLUH
Glutathione
Cristae
Mitochondrial dynamics

description: The cell possesses a number of vital mechanisms to respond to different stressors. Mitochondria are dynamic organelles which undergo constant changes in length, transport and inner membrane structure and curvature. Invaginations of this inner membrane, cristae, have been known to respond to the energetic state of mitochondria, but the regulation of these changes as well as the consequences thereof remain undetermined. We find that Optic Atrophy 1 (OPA1), a protein involved in inner membrane fusion and cristae maintenance during cell death, can respond to the energetic state of mitochondria and the cell. Moreover, OPA1-dependent changes in cristae structure are required for resistance to starvation induced cell death, proper functioning of the electron transport chain, for growth in galactose media and for maintenance of ATP synthase assembly. Interestingly, we demonstrate that select members of the mitochondrial solute carriers (SLC25A) interact with OPA1 and affect the response of OPA1 to substrate levels. Taken together, we propose an SLC25A-dependent role for OPA1 in sensing energy substrate availability and responding to alter cristae, bioenergetics and cellular survival. We also identified KIAA0664 as a novel OPA1-interacting protein, describe its subcellular localization and investigate its role in mitochondrial fusion and in mitochondrial localization. Finally, since both known carriers of mitochondrial glutathione were demonstrated to interact with OPA1, we investigated the role of OPA1 in cellular glutathione redox. OPA1 depleted cells demonstrated both increased total cellular glutathione and a shift in redox to its reduced form. The role of OPA1 in glutathione levels and redox ratios required GTPase activity, but surprisingly not fusion. Since glutathione is a master regulator of reactive oxygen species detoxification, these findings may shed light on the role of OPA1 in ROS-induced cell death pathways.
Nutrition infantile et maternelle : Évaluation procédurale du Projet d’appui à l’amélioration nutritionnelle au Bénin
Creators: name: Graveline, Sophie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Malnutrition infantile
Malnutrition maternelle
Bénin
Évaluation
Évaluation de projet
Évaluation procédurale
Développement international

description: La malnutrition infantile et maternelle est un enjeu mondial qui affecte des millions d’enfants et de femmes, surtout dans les pays en développement. Le Projet d’appui à l’amélioration nutritionnelle au Bénin, réalisé par l’Association des personnes rénovatrices des technologies traditionnelles et la Fondation Paul Gérin-Lajoie, mise sur l’éducation nutritionnelle pour aborder cet enjeu. Le but de cette recherche est de faire une évaluation procédurale de ce projet afin de constater si sa mise en œuvre est pertinente relativement à la situation nutritionnelle des villages du Mono. La logique du minimum evaluation procedure a été respectée. Ainsi, plutôt que d’évaluer les résultats, ce sont les services offerts et l’utilisation de ces services par les bénéficiaires qui sont évalués. Grâce à la recherche menée sur le terrain, il est démontré que le projet répond partiellement aux besoins nutritionnels locaux, puisque les initiatives mises en œuvre dans le cadre du PAAN ne permettent pas de répondre adéquatement aux problèmes nutritionnels locaux (retard de croissance, insuffisance pondérale, carences, etc.). Cette recherche démontre aussi que, dans le cadre de projets nutritionnels, la mise en œuvre d’activités d’éducation nutritionnelle n’est pas suffisante. En plus de prendre en considération les ressources (agricoles, nutritives, sanitaires et financières) disponibles, le projet doit être en complémentarité avec les services offerts par les autres acteurs présents sur le terrain. La recherche a néanmoins permis de constater que les attentes des bénéficiaires du PAAN semblent être atteintes.
Investigating sustainable strategies for turning around 'stunted growth' businesses
Creators: name: Bianchi, Carmine
name: Winch, Graham W.
Publisher: name: Swinburne
Year: 2024

description: Within the range of small companies, and especially micro-firms, there is a group that have survived through many years, maybe many generations, providing their owners with acceptable returns and lifestyles, but have remained very small despite them having significant growth potential. This phenomenon is recognised in the literature as the 'dwarf ' or 'stunted' small firm (in Italian nanismo aziendale ). The ability of such firms to break out from this situation varies according to external opportunities, but especially with regard to internal strategic resources and the attributes of the owner-entrepreneurs. Previous work by the authors has used case study evidence to characterise different firms and has then presented qualitative analysis to provide some initial ideas in how such firms could break out from this condition. This earlier work lead to the conclusion that a business simulator could be of significant value in investigating the change process, and a preliminary model was posited. The work described in this paper builds from that earlier work by presenting a fully developed insight model. This model includes a more extensive representation of critical strategy assets, reflects the base dynamics (or 'reference behaviour mode') expected of stunted firms, and then examines a wide range of scenarios representing different constraints and opportunities for entrepreneurs to change their firms into ones that could achieve long-term sustainable growth.
Values are not enough: qualitative study identifying critical elements for prioritization of health equity in health systems
Creators: name: Van Roode, Thea
name: Pauly, Bernadette
name: Marcellus, Lenora
name: Strosher, Heather W.
name: Shahram, Sana Z.
name: Dang, Phuc
name: Kent, Alex
name: MacDonald, Marjorie
Publisher: name: BioMed Central
Year: 2020

description: Background Health system policies and programs that reduce health inequities and improve health outcomes are essential to address unjust social gradients in health. Prioritization of health equity is fundamental to addressing health inequities but challenging to enact in health systems. Strategies are needed to support effective prioritization of health equity. Methods Following provincial policy recommendations to apply a health equity lens in all public health programs, we examined health equity prioritization within British Columbia health authorities during early implementation. We conducted semi-structured qualitative interviews and focus groups with 55 senior executives, public health directors, regional directors, and medical health officers from six health authorities and the Ministry of Health. We used an inductive constant comparative approach to analysis guided by complexity theory to determine critical elements for prioritization. Results We identified seven critical elements necessary for two fundamental shifts within health systems. 1) Prioritization through informal organization includes creating a systems value for health equity and engaging health equity champions. 2) Prioritization through formal organization requires explicit naming of health equity as a priority, designating resources for health equity, requiring health equity in decision making, building capacity and competency, and coordinating a comprehensive approach across levels of the health system and government. Conclusions Although creating a shared value for health equity is essential, health equity - underpinned by social justice - needs to be embedded at the structural level to support effective prioritization. Prioritization within government and ministries is necessary to facilitate prioritization at other levels. All levels within health systems should be accountable for explicitly including health equity in strategic plans and goals. Dedicated resources are needed for health equity initiatives including adequate resourcing of public health infrastructure, training, and hiring of staff with equity expertise to develop competencies and system capacity.
title: Checklisten für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie
title: Zellulose- und Papierindustrie: Checkliste Nr. ZT. 3: Zellstoffk.
titleType: AlternativeTitle
Creators: name: Winkelmann-Oei, Gerhard
Publisher: name: My University
Year: 2016
Subjects: subject: Papierindustrie
subject: Zellstoffindustrie
subject: Gewässerschutz
subject: Wasserverunreinigung
subject: Risikomanagement
subject: Leitfaden
subject: Zelluloseindustrie
subject: Zellstoffproduktion
subject: Wasserverschmutzung
subject: Wasserschadstoffe
subject: Checkliste
subject: Chemikalien
subject: Chemicals

description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren. Quelle: Bericht
description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren.
The psychophysiological basis of creativity and intuition: accessing 'the zone' of entrepreneurship
Creators: name: Tomasino, Dana
name: Bradley, Raymond Trevor
Publisher: name: Swinburne
Year: 2024

description: Successful entrepreneurs are innovators and risk-takers who appear to have an extraordinary ability to know where future business opportunities will eventuate and how to profitably actualize these ventures. The patterns of thought and action displayed by entrepreneurs are thus informed by an unusually high degree of both creativity and intuition. Research conducted by the Institute of HeartMath has made significant progress in elucidating the psychophysiological basis of creativity and intuition. We have identified a distinct psychophysiological state which appears to enhance creativity and intuitive perception. This state, termed psychophysiological coherence , is characterized by a system-wide shift toward increased order, synchronization, and harmony in an individual's physiological and psychological processes. We have shown that the coherent state is naturally activated during the experience of sustained positive emotions. This presentation will describe the physiological and psychological correlates of coherence and discuss how this state facilitates the processes underlying creativity and intuition. Examining creative and intuitive processes as body-wide phenomena, we will give particular attention to the important role played by interactions between the heart and brain. The second part of the presentation will introduce practical techniques and technology developed by the Institute of HeartMath to help people learn how to self-activate the psychophysiological coherence state at will.
АНАЛИЗ ИММИГРАЦИОННОЙ ПРАВОВОЙ БАЗЫ ОБЪЕДИНЕННЫХ АРАБСКИХ ЭМИРАТОВ В КОНТЕКСТЕ ЭКОНОМИЧЕСКОЙ ДИВЕРСИФИКАЦИИ И СОЦИАЛЬНО-КУЛЬТУРНОГО СОХРАНЕНИЯ
Creators: name: Очилов, Аслиддин
Publisher: name: Zenodo
Year: 2024

description: В этой статье представлен всесторонний анализ иммиграционной правовой базы Объединенных Арабских Эмиратов (ОАЭ), помещая ее в более широкий контекст национальных стратегий экономической диверсификации и усилий по сохранению социо-культурной идентичности. Посредством многогранного анализа это исследование исследует сложную взаимосвязь между иммиграционной политикой, динамикой рынка труда и формированием национальной идентичности в ОАЭ. В исследовании используется смешанный подход, включающий анализ правовой доктрины, сравнительно-правовые исследования и социально-правовые аспекты для выяснения сложностей, присущих иммиграционному режиму ОАЭ. В этой статье утверждается, что иммиграционные законы ОАЭ представляют собой тонкий баланс между содействием экономическому росту посредством привлечения иностранных талантов и инвестиций и одновременной защитой национального культурного наследия и социальной структуры. Исследование завершается критическим анализом проблем и возможностей, которые представляет собой развивающаяся иммиграционная среда ОАЭ, а также предлагает потенциальные пути правовой и политической реформы для повышения эффективности и справедливости системы.
The Role of Coenzyme Q10 in Statin Treated Zebrafish (Danio rerio)
Creators: name: Pasha, Rand
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014

description: Atorvastatin (ATV) is a member of the statin family of pharmaceuticals sold as Lipitor™ by Pfizer Pharmaceuticals. Statins inhibit HMG-Coenzyme A reductase (HMG-CoAR), thus inhibiting the biosynthesis of cholesterol and other isoprenoid compounds including Coenzyme Q10 (CoQ10). This study evaluated the role of CoQ10 in preventing ATV-induced myotoxicity using the zebrafish Danio rerio as a model organism. ATV reduced spontaneous swimming, response to tactile stimuli, whole body enzyme activities (citrate synthase, cytochrome oxidase and lactate dehydrogenase) as well as increased pericardial sac edema in larvae. Transcript abundance of muscle atrophy markers (atrogen-1, murf) and the mitochondrial biogenesis marker (pgc-1α) were also altered. Additionally, acute toxicity of adult zebrafish resulted in no change in locomotor behaviour; however tissue enzyme activities and transcript abundance were altered. These findings demonstrate the protective effect of CoQ10 against larval ATV-meditated reduction in responses to tactile stimuli and enzyme activities suggesting CoQ10 does play a role in ATV-mediated toxicity.
Molecular insights into the formation and remobilization potential of nonextractable anthropogenic organohalogens in heterogeneous environmental matrices
Creators: name: Zhu, Xiaojing
name: Ricking, Mathias
name: Dsikowitzky, Larissa
Publisher: name: My University
Year: 2019

description: Anthropogenic organohalogens (AOHs) are toxic and persistent pollutants that occur ubiquitously in the environment. An unneglectable portion of them can convert into nonextractable residues (NER) in the natural solid substances. NER-AOHs are not detectable by conventional solvent-extraction, and will get remobilized through changes of surrounding environment. Consequently, the formation and fate of NER-AOHs should be investigated comprehensively. In this study, solvent extraction, sequential chemical degradation and thermochemolysis were applied on different sample matrices (sediments, soils and groundwater sludge, collected from industrial areas) to release extractable and nonextractable AOHs. Covalent linkages were observed most favorable for the hydrophilic-group-containing monocyclic aromatic AOHs (HiMcAr-AOHs) (e.g. halogenated phenols, benzoic acids and anilines) incorporating into the natural organic matter (NOM) as NER. Physical entrapment mainly contributed to the NER formation of hydrophobic monocyclic aromatic AOHs (HoMcAr-AOHs) and polycyclic aromatic AOHs (PcAr-AOHs). The hypothesized remobilization potential of these NER-AOHs follow the order HiMcAr-AOHs > HoMcAr-AOHs/ aliphatic AOHs > PcAr-AOHs. In addition, the NOM macromolecular structures of the studied samples were analyzed. Based on the derived results, a conceptual model of the formation mechanisms of NER-AOHs is proposed. This model provides basic molecular insights that are of high value for risk assessment and remediation of AOHs. © 2019 Elsevier B.V. All rights reserved.
Attitudes towards superannuation in Australia
Creators: name: Drew, Matthew S.
Publisher: name: Swinburne
Year: 2024

description: The aging of Australia’s population over the next 40 years is going to put pressure on the Australian government to fund the lifestyles of the nation’s retirees. Current research shows that the current arrangements that are in place will not be sufficient to maintain an adequate standard of living in retirement. A specially designed online questionnaire was developed to gain an understanding of the attitudes and perceptions of Australians towards superannuation and retirement planning. The aim was to develop some strategies and recommendations for change for the government and the superannuation industry to implement to ensure Australians will have sufficient retirement savings by the time the retire.
L'exilé de toute part suivi de la Poétique négro-africaine de l'exil
Creators: name: Ntafatiro, Patrice
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Exil culturel, géographique, physique, métaphysique, écriture, dictatorial, colonial
Batimbo, Abatimbo, Nkeshimana Emmanuel, France,
La Blessure sacrée de Césaire
Poésie négro-africaine et burundaise
poésie des vers libres
poèmes en prose
versets
les unités discursives des odes burundaises
Burundi précolonial, colonial et postcolonial
les Burundaises
les Burundais
La colonisation allemande et belge au Burundi
la déportation
l'esclavage
les tirailleurs sénégalais
la deuxième guerre mondiale
Lyrisme
lyrique
poésie de circonstance
rêve réalité
élément déclencheur
postexil
immigration
émigration
idéalisation ou mythisation de la terre natale ou pays perdu
représentation négative de la terre d'adoption ou pays hôte
Afrique ce premier continent
Kirimiro
Gitega
Giheta
Muremera
Rutongati
Mwamira
Umwamira
Ncaramba
Nyabunyovu
Rwire
Ruyigi
Ruvyironza
Ruvubu
Ruru
Sénégal
Martinique
République Démocratique du Congo
Antilles
Afrique de l'est
Région des Grands Lacs africains
Léopold Sédar Senghor
AntoineTshitungu Kongolo
Kayoya Michel
Aimé Césaire
Gaspard Bayaganakandi
Kasereka Kavwahirehi

description: Grâce à une réflexion sur ma création poétique, cette thèse exploite « la poétique négro-africaine de l’exil » à travers cinq recueils de Césaire, Kayóya, Senghor et Tshitungu Kongolo. D’une part, mon recueil extériorise les joies et les peines du Burundi précolonial, colonial, postcolonial et d’un exilé francophone au Canada largement anglophone. Mes exigences esthétiques sont, premièrement, l’emploi des figures de style pour que mes poèmes soient des paroles plaisantes au cœur et à l’oreille. Deuxièmement, chaque poème véhicule une poly-isotopie. Troisièmement, pareil à mon identité hybride, mon recueil est un mariage de la poésie des vers courts français et des unités discursives burundaises. D’autre part, mon analyse critique examine la manière dont le poète exilé idéalise le pays perdu et suggère des réserves face au pays hôte qui lui impose une nouvelle identité. Ensuite, mon analyse révèle que l’écriture poétique est en elle-même un exil.
The Operations of Building Companies in Wrocław in the 2nd Half of the 19th Century.
Creators: name: Grzegorczyk, Bożena
Publisher: name: Faculty of Architecture, Wrocław University of Technology, Wrocław
Year: 2012
Subjects: History of architecture, Wroclaw, Breslau

description: ARCHITECTUS; 31; 35-42; ISSN 1429-7507
Il piano di stakeholder engagement del progetto PNRR CS4RIVERS - biodiversità, citizen science e contesti locali
Creators: name: Radicchi, Antonella
name: Capineri, Cristina
Publisher: name: Zenodo
Year: 2024

description: I progetti e le iniziative di citizen science si fondano sulla partecipazione volontaria di cittadini e stakeholders che in diverse fasi del progetto e con differenti gradi dipartecipazione contribuiscono alle attività di progetto quali la formulazione delle domande scientifiche che orientano i progetti, la raccolta e l’analisi dei dati generatidurante le attività di campo e la disseminazione dei risultati conseguiti. Il coinvolgimento continuativo e la partecipazione attiva dei cittadini e di stakeholdersappartenenti a diversi settori (educativo, governativo etc.) costituisce una delle chiavi di successo dei progetti di citizen science e allo stesso tempo un fattore critico. In letteratura così come nelle sedi dedicate al dibattito disciplinare italiano e internazionale si discute da tempo della funzionalità e dell’efficacia di modelli teorici e metodi di coinvolgimento utilizzati dagli studiosi e dai citizen scientists all’interno di progetti nazionali e internazionali. Sullo sfondo di queste considerazioni, scopo di questa presentazione è condividere la metodologia di engagement che supporta lo Stakeholder Action Plan ideato e utilizzato contestualmente al progetto PNRR CS4RIVERS - biodiversità, citizen science e contesti locali, per la costituzione dell’Osservatorio di citizen science della biodiverstà fluviale del fiume Ombrone in Toscana. Nello specifico, sarà presentata i) la metodologia composta dal modello di innovazione 5-Helix, la matrice power/interest e il modello multilevel stakeholder engagement e ii) i risultati ottenuti dall’applicazione di questa metodologia durante il primo anno di sviluppo del progetto.
The Urban Transformations of the Health Resort in Lądek Zdrój before 1945.
Creators: name: Trocka-Leszczyńska, Elżbieta
name: Tomaszewicz, Agnieszka
Publisher: name: Faculty of Architecture, Wrocław University of Technology, Wrocław
Year: 2012
Subjects: Silesia, Lądek Zdrój, health resort, urban development

description: ARCHITECTUS; 31; 43-52; ISSN 1429-7507
Biomaterial-Stem Cell Approaches to Augment Regeneration
Creators: name: Kuraitis, Drew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013

description: Diseases affecting striated muscle are prevalent and deadly in both the Western and developing worlds. Such diseases include peripheral arterial disease and coronary artery disease, characterized by reduced blood flow to extremities and heart muscle, respectively, all of which manifest as reduced function & quality-of-life. Although promising in animal models, many clinical trials of stem cell therapy have yielded modest results at best. Growing evidence suggests that in a disease state, improvements in local environments using natural methods that already exist in the body hold great promise for supporting recovery and regeneration. This may be accomplished by exploiting natural progenitor cell functions and interactions with endogenous extracellular matrix (ECM) components, pro-regenerative cytokines and ligands. This thesis uses ECM-mimicking, collagen-based matrices to improve the regenerative response. Specifically, such a matrix is demonstrated to improve the potency of ex vivo expanded circulating angiogenic cells for treatment of ischemic muscle (Chapter 2). Matrices were also functionalized to release chemoattractant molecules to improve the recruitment of progenitor cells (Chapter 3) and to present progenitor cell-binding ligands for improved cell retention in ischemic muscle (Chapter 4), with the ultimate goal of restoring perfusion. Matrices were also observed to improve muscle function and augment muscle regeneration in models of ischemic and dystrophic muscle (Chapters 4 & 5). The results of this thesis provide insights into the ability to modulate regeneration in vivo with treatment of biomaterials that have been designed to exploit and amplify progenitor cell responses. Specifically, this thesis contains some of the first reports for the use of ECM-based biomaterials to stimulate passive enrichment of circulating angiogenic cells, functional regeneration of muscle, and a potential method of benefitting from necrosis. These data provide an interesting pilot perspective on improvements or alternatives to cell therapy, and future studies will seek to better tune these prospective therapies so that one day they may be clinically available.
title: Numerical Studies of the A6 Relativistic Magnetron Using Particle-In-Cell Simulations
Creators: name: Jujjavarapu, Vineetha
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2014

description: The magnetron became a major component in radar systems around the time of the World War II. More recent radar techniques require short microwave pulses (with nanosecond pulse-widths for ultra wideband operations) and high peak power in the Giga-Watt range. In order to achieve these specifications for the military, the magnetron needs to have both a fast start and the rapid growth rate of oscillations in order to serve as a microwave source for the short-pulse applications. These two factors depend on the geometry of the cathode. Other requirements include high conversion efficiency and low leakage current (in order to avoid damage and enhance device reliability).

This thesis focuses on computer simulations as a proof of concept and provides quantitative predictions of output performance parameters such as efficiency, output power, operating frequency, and leakage currents. The magnetron perfonnance results of both the solid and the transparent cathode are compared. The transparent cathode was invented at the University of New Mexico to improve the start time and achieve fast build-up of oscillations in short-pulse relativistic magnetrons. From a solid cathode, longitudinal snips are removed to construct the transparent cathode. The number of strips is chosen to match the number of anode blocks and equals six for the A6 magnetron.

In addition, the role of secondary electron emission (SEE) on the output power is evaluated in this thesis research through particle-in-cell simulations. The simulation results seem to indicate that SEE would be detrimental to the power output from the A6 relativistic magnetron. This is linked to deviations in the starting trajectories of secondary electrons following their generation and the lowered fraction with a synchronized rotational velocity for the cluster. A peak power output of about 1.33GW is predicted at a magnetic field of 0.65 T. A higher reduction in output power has been predicted for repeated secondary emissions through electron cascading. Finally, the role of end-caps on the cathode for potentially reducing the leakage current has been probed. The central goal is to conduct a parameter study that comprehensively incorporates performance enhancing features such as the use of endcaps and cathode extensions. The numerical simulation results demonstrate peak output power in excess of I GW, with leakage currents below 50 Amperes and efficiencies on the order of 66% for B-field in the 0.4 T- 0.42 T range.
How to optimize the design and implementation of risk prediction tools : focus group with patients with IgA nephropathy
Creators: name: Gagliardi, Anna R
name: Reich, Heather N
name: Cattran, Daniel C
name: Barbour, Sean J.
Publisher: name: BioMed Central
Year: 2020

description: Background IgA nephropathy (IgAN) is a common type of chronic immune-mediated kidney disease with variable risk of progression to end-stage kidney disease. Risk stratification helps clinicians weight the potential risks and benefits of immunosuppressive therapy for individual patients, and can inform patient-centred communication. No prior research examined barriers of risk predication tools (RPT) specific to IgAN. The purpose of this study was to explore determinants (facilitators, barriers) of RPT use from the patient perspective. Methods We conducted a single focus group with English-speaking adults aged 18 or older with biopsy-proven IgAN. We asked about how they would use an IgAN RPT, and how to improve its design and implementation. We analyzed the transcript using constant comparison to inductively derive themes, and complied with qualitative research reporting criteria. Results The 5 participants were Caucasian men who varied in age from 35 to 55. The glomerular filtration rate ranged from 29 to 71 mL/min/1.73m2, and proteinuria ranged from 0.36 to 1.41 g/d. Participants identified both benefits and harms of the risk score. They said physicians should first ask patients for permission to use it. To make it more useful, participants offered suggestions to enhance RTP design: visual display, information on how to interpret the risk score, risk categories, health implications, modifiable risk factors, multiple scenarios, and comparison with similar patients. They offered additional suggestions to enhance RPT implementation: it should not replace patient-provider discussion, it should be accompanied by self-management education so that patients can take an active role in their health. Participants appreciated information from members of the multidisciplinary team in addition to physicians. Participants also said that physicians should monitor patient emotions or concerns on an ongoing basis. Conclusions Patients with IgAN identified numerous ways to enhance the design and use of an RPT. Others could use this information to design and implement RPTs for patients with other conditions, but should employ user-centred design to develop RPTs that address patient preferences.
The Layout of the Municipal Cemetery in Opole Półwieś in Gustav Allinger's project
Creators: name: Adamska, Monika Ewa
Publisher: name: Faculty of Architecture, Wrocław University of Technology, Wrocław
Year: 2012
Subjects: 20th century landscape architecture, cemetery, Opole, Gustav Allinger

description: ARCHITECTUS; 31; 53-62; ISSN 1429-7507