cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Propofol abolishes torsade de pointes in different models of acquired long QT syndrome
Creators: name: Ellermann, Christian
name: Könemann, Hilke Maren
name: Wolfes, Julian
name: Rath, Benjamin
name: Wegner, Felix K.
name: Willy, Kevin Kurt
name: Dechering, Dirk G.
name: Reinke, Florian Johann
name: Eckardt, Lars
name: Frommeyer, Gerrit
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 610 Medicine and health

description: There is conflicting evidence regarding the impact of propofol on cardiac repolarization and the risk of torsade de pointes (TdP). The purpose of this study was to elucidate the risk of propofol-induced TdP and to investigate the impact of propofol in drug-induced long QT syndrome. 35 rabbit hearts were perfused employing a Langendorff-setup. 10 hearts were perfused with increasing concentrations of propofol (50, 75, 100 µM). Propofol abbreviated action potential duration (APD90) in a concentration-dependent manner without altering spatial dispersion of repolarization (SDR). Consequently, no proarrhythmic effects of propofol were observed. In 12 further hearts, erythromycin was employed to induce prolongation of cardiac repolarization. Erythromycin led to an amplification of SDR and triggered 36 episodes of TdP. Additional infusion of propofol abbreviated repolarization and reduced SDR. No episodes of TdP were observed with propofol. Similarly, ondansetron prolonged cardiac repolarization in another 13 hearts. SDR was increased and 36 episodes of TdP occurred. With additional propofol infusion, repolarization was abbreviated, SDR reduced and triggered activity abolished. In this experimental whole-heart study, propofol abbreviated repolarization without triggering TdP. On the contrary, propofol reversed prolongation of repolarization caused by erythromycin or ondansetron, reduced SDR and thereby eliminated drug-induced TdP.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
title: La construction du savoir prosodique et l'interdisciplinarité (France, 1530-1660)
Creators: name: Schweitzer, Claudia
Publisher: name: Universität Graz
Year: 2022

description: La prosodie se réfère à la réalisation orale de la parole selon l'usage propre de la langue en général
et selon la volonté de l'expression du locuteur en particulier. Les grammairiens, ne disposant pour
l'étude des phénomènes prosodiques pas encore des outils techniques modernes, ne pouvaient se
servir que de leur proprioception et de la comparaison avec l'étude d'autres phénomènes. Dans l'effort
pour décrire les phénomènes qui leur semblent importants, les grammairiens français s'inspirent
donc souvent d'autres domaines : la poésie, la rhétorique et la musique. Cet article s’intéresse
à la construction de la description de la prosodie dans le domaine de la grammaire du 16e et
du début du 17e siècle, et notamment aux apports et aux influences des théories et des modèles
d'autres domaines.
description: Prosody refers to the oral realization of a word that is both conventionally appropriate and apt for
expression of a particular speaker meaning. Traditional grammarians, who did not have modern
technical tools for the study of prosodic phenomena yet, could only use their proprioception and
rely on comparison with other phenomena already studied. In their effort to describe the phenomena
they considered important, French grammarians thus looked for inspiration in other fields: poetry,
rhetoric and music. This article addresses the description of prosody in the grammars of the
16th and early 17th centuries, and in particular the contributions and influences of theories and
models from other fields.
description: Studia linguistica romanica 2022.7, 21-50
Who Are Vidyādhara ?
Creators: name: RODRIGUES, TENSING CARLOS
Publisher: name: figshare
Year: 2017
Subjects: subject: History
subject: Anthropology
subject: FOS: Sociology
subject: Archaeology
subject: Geography
subject: Sociology

description: Putting together what we can assemble from the Jaina Rāmāyaṇa and the Bṛhatkathā, we can roughly locate the vidyādhara territory on either side of the Vindhya, probably more towards the east, rather than the west : the eastern Indo-Gangetic plain with its counterpart in the Deccan across the Narmada. Our interest in the Vidyādhara lies in the light it could throw on the interaction of the Indo-Gangetic kshatriya with the vaḍukar ? That is what we expect Rāmāyaṇa to help us in. The time is appropriate : the beginnings of the Common Era. That is when perhaps the kshatriya, with or without the brāmhaṇa, entered into a major encounter with the vaḍukar, the inhabitants of the middle India.
The evolutionary history of Ephs and ephrins: toward multicellular organisms.
Creators: name: Arcas, Aida
name: Wilkinson, David G
name: M Ángela Nieto
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Human Biology & Physiology
subject: Stem Cells
subject: Model organisms

description: Eph receptor (Eph) and ephrin signalling regulates fundamental developmental processes through both forward and reverse signalling triggered upon cell-cell contact. In vertebrates, they are both classified into classes A and B, and some representatives have been identified in many metazoan groups, where their expression and functions have been well studied. We have extended previous phylogenetic analyses and examined the presence of Eph and ephrins in the tree of life to determine their origin and evolution. We have found that (i) premetazoan choanoflagellates may already have rudimental Eph/ephrin signalling as they have an Eph-/ephrin-like pair and homologues of downstream signalling genes; (ii) both forward and reverse downstream signalling might already occur in Porifera since sponges have most genes involved in these types of signalling; (iii) the non-vertebrate metazoan Eph is a type-B receptor that can bind ephrins regardless of their membrane anchoring structure, glycosylphosphatidylinositol or transmembrane; (iv) Eph/ephrin cross-class binding is specific to Gnathostomata and (v) kinase-dead Eph receptors can be traced back to Gnathostomata. We conclude that Eph/ephrin signalling is of older origin than previously believed. We also examined the presence of protein domains associated with functional characteristics and the appearance and conservation of downstream signalling pathways to understand the original and derived functions of Ephs and ephrins. We find that the evolutionary history of these gene families points to an ancestral function in cell-cell interactions that could contribute to the emergence of multicellularity and, in particular, to the required segregation of cell populations.
title: Long-term mechanical behavior of claystone
Creators: name:  Mayr ,  Sibylle Irene
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: For decades, claystone is investigated as a likely host rock material for the deep geological disposal of highly radioactive waste. To ensure safe operation, knowledge about the long-term (thermo-hydro-) mechanical behavior of clay rock is of significant relevance: How will the excavation induced differential stresses gradually dissipate while causing convergence? Laboratory triaxial tests on the mechanical behavior allow for the controlling of major and minor principal stress (differential stress), pore pressure (effective stress), saturation, temperature and loading history. Long-term deformation tests running at low differential stresses reveal gradually declining deformation rates (consolidation + primary creep). With time, the deformation process asymptotically approaches an apparently constant deformation rate at constant volume (secondary creep). At higher differential stresses, accelerated tertiary creep occurs, associated with dilatant deformation and forming of new microcracks, leading to final failure of the specimen. In claystones the primary consolidation process is slow and comparatively well understood: due to low hydraulic conductivity pore fluid is slowly squeezed out, at the same time rearrangement of clay particles and micro grains takes place leading to changes in the microstructure. Moreover, rearrangements in the grain skeleton with a variable deformation rate can occur at constant effective pressure. This creep process is hard to determine and still poorly understood. Only very long creep tests give the possibility to detect secondary creep and to distinguish it from primary consolidation processes. Creep tests run over several months/years on clays from Mont Terri give examples of the settlement mentioned and different types of creep.
AN_UNUSUAL_POWER_THE_CULTURAL_CONSTRUCTI.odt
Creators: name: Wilkin, Stanley
Publisher: name: figshare
Year: 2017
Subjects: subject: 111005 Mental Health Nursing
subject: FOS: Health sciences
subject: 111710 Health Counselling
subject: 111708 Health and Community Services
subject: Health Care
subject: 209999 Language, Communication and Culture not elsewhere classified
subject: FOS: Languages and literature

description: How madness has been understood, how it is negotiated and the role of doctors.
title: La comparaison dans Philandre (1544) Procédures figuratives en contexte narratif
Creators: name: Mounier, Pascale
Publisher: name: Universität Graz
Year: 2022

description: La comparaison participe à l'élaboration des types de texte en s'adaptant aux contraintes formelles
des genres et aux principes de la production des discours, qui évoluent dans le temps. Elle joue en
l'occurrence plusieurs rôles dans l'élaboration des séquences narratives de Philandre, un roman de
chevalerie composé par Jean des Gouttes et publié en 1544. Une double approche de linguistique
textuelle et de stylistique historique permet d'identifier trois grandes procédures figuratives à
l'oeuvre dans les énoncés comparatifs de ces passages, qui méritent une description et une analyse.
La première consiste dans l'expression du haut degré des propriétés qui fondent la ressemblance, la
seconde dans la recherche de précision dans l'identification de celles-ci et la troisième dans l'évaluation
des éléments rapprochés et de l'acte de comparaison
description: Comparison contributes to shape the text types by adapting to the formal constraints of genres and
the principles of speech production, which change over time. It plays several roles in the elaboration
of the narrative sequences of Philandre, a chivalric romance composed by Jean des Gouttes
and published in 1544. Combining textual linguistics and historical stylistics, this study identifies,
describes and analyzes three major figurative procedures performed in the comparative utterances
of the romance. The first step is the description of numerous properties that form the basis of the
resemblance, the second provides a framework for a more refined and precise identification of
these properties and the third evaluates and compares the related elements.
description: Studia linguistica romanica 2022.7, 51-73
title: Tectonic accretion controls erosional cyclicity in the Himalaya
Creators: name:  Scherler ,  Dirk
name:  Mandal ,  Sanjay Kumar
name:  Wittmann ,  Hella
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Indian Institute of Science Education and Research Kolkata, Mohanpur, India(3);The evolution of Earth’s climate over geological timescales is linked to surface erosion by weathering of silicate minerals and burial of organic carbon. However, methodological difficulties in reconstructing erosion rates through time and feedbacks among tectonics, climate, and erosion spurred an ongoing debate on mountain erosion sensitivity to tectonic and climate forcing. A key question is whether late Cenozoic climate cooling has increased global erosion rates or not. The Himalaya plays a prominent role in this debate as its erosion produces a large fraction of global sediments delivered to ocean basins. We report a 6-Myr-long record of cosmogenic 10Be-derived erosion rates from the north-western Himalaya, which indicates that erosion rates in this region varied quasi-cyclically with a period of ~1 Myr and increased gradually towards the present. We hypothesize that the observed pattern of erosion rates occurred in response to the tectonic growth of the Himalaya by punctuated basal and frontal accretion of rocks from the underthrusting Indian plate and concomitant changes in topography. In this model, basal accretion episodically changes rock-uplift patterns, which brings landscapes out of equilibrium and results in quasi-cyclic variations in erosion rates. We used numerical landscape evolution simulations to demonstrate that this hypothesis is physically plausible. In addition, we suggest that the long-term increase in erosion rates was likely driven by successive basal accretion and the commensurate topographic growth in the interior of the Himalayan thrust wedge. Because tectonic accretion processes are inherent to collisional orogenesis, they likely confound climatic interpretations of erosion rate histories.
Rapid identification of chemical composition and quality markers of Gynostemma pentaphylla by ultra-performance liquid chromatography combined with triple quadrupole mass spectrometry connected with high-performance liquid chromatography
Creators: name: Wang, Yumeng
name: Wu, Yunshan
name: Wang, Siyu
name: Chen, Weiying
name: Chen, Lei
name: Han, Xiaodong
name: Liu, Bo
name: Wang, Shumei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology

description: Gynostemma pentaphylla, one of the traditional Chinese medicinal materials, which has gradually become a research hotspot due to its rich pharmacological activities such as hypolipidemic properties, anti-inflammatory, anti-cancer and etc. The main active ingredients of Gynostemma pentaphyllum are saponins (gypenoside), flavonoids and polysaccharides. The pharmacologically active dose depends on the content of the active ingredient, so it is necessary to establish a reliable quality evaluation standard for Gynostemma pentaphyllum. However, the existing Gynostemma pentaphyllum quality control methods are not perfect, Ginsenoside Rb1 was regarded as a signature ingredient of Gynostemma pentaphylla in local standards. Surprisingly, the high-performance liquid chromatogram results displayed that the content of Ginsenoside Rb1 was not suitable as a quality marker. Therefore, a triple quadrupole time-of-flight tandem mass spectrometer method was developed to explore other potential quality markers in Gynostemma pentaphylla. As a result, a total of 24 compounds was identified tentatively. While another stable and reliable component Gypenoside XLVI was found and the content was carried out. It was expected to replace Ginsenoside Rb1 to establish a more reliable and precise quality standard of Gynostemma pentaphylla.
Additional file 1 of The impact of exercise interventions concerning executive functions of children and adolescents with attention-deficit/hyperactive disorder: a systematic review and meta-analysis
Creators: name: Liang, Xiao
name: Li, Ru
name: Wong, Stephen H. S.
name: Sum, Raymond K. W.
name: Sit, Cindy H. P.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1.
Linalool - Molecule of the Month October 2013 [Archived version]
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for October 2013 about linalool. It is a pdf archive version of the HTML webpage.
Additional file 2 of Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients
Creators: name: Zhou, Zhen
name: Ding, Zhengping
name: Yuan, Jie
name: Shen, Shengping
name: Jian, Hong
name: Tan, Qiang
name: Yang, Yunhai
name: Chen, Zhiwei
name: Luo, Qingquan
name: Cheng, Xinghua
name: Yu, Yongfeng
name: Niu, Xiaomin
name: Qian, Liqiang
name: Chen, Xiaoke
name: Gu, Linping
name: Liu, Ruijun
name: Ma, Shenglin
name: Huang, Jia
name: Chen, Tianxiang
name: Li, Ziming
name: Ji, Wenxiang
name: Song, Liwei
name: Shen, Lan
name: Jiang, Long
name: Yu, Zicheng
name: Zhang, Chao
name: Tai, Zaixian
name: Wang, Changxi
name: Chen, Rongrong
name: Carbone, David P.
name: Xia, Xuefeng
name: Lu, Shun
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 2: Supplementary Results.
In situ TEM observation of phase transformation in bulk metallic glass composites
Creators: name: Sheng, Huaping
name: Zhang, Long
name: Zhang, Haifeng
name: Wang, Jianbo
name: Eckert, Jürgen
name: Gammer, Christoph
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plasma Physics

description: Transformation-induced plasticity is a fundamental solution for improving the ductility of bulk metallic glass composites (BMGCs). However, the underlying mechanism remains controversial. Here, by using in situ transmission electron microscopy, we present direct observation of the transformation dynamics from β/ω phase to α’ phase of the crystalline dendrites in a TiZrCuBe BMGC under uniaxial tensile deformation. The transformation redistributes the stress in the adjacent matrix, making interfacial regions potential preferential sites for shear band nucleation. The high density of nucleation sites is believed to promote the formation of shear band networks and enhance the ductility of BMGCs.
Servant Leadership for Emerging International Higher Educational Institutions
Creators: name: James, Alex Pappachen
Publisher: name: figshare
Year: 2017
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences
subject: Education
subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: 130199 Education systems not elsewhere classified
subject: 130105 Primary Education (excl. Maori)
subject: 130101 Continuing and Community Education
subject: 160506 Education Policy
subject: FOS: Political science
subject: 160599 Policy and Administration not elsewhere classified
subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business
subject: 150314 Small Business Management
subject: 150308 International Business
subject: Uncategorized

description: This article provides the perspectives on servant leadership in academic administration context of young international universities that aim global excellence and recognition.
ALMOND: Adaptive Latent Modeling and Optimization via Neural Networks and Langevin Diffusion
Creators: name: Qiu, Yixuan
name: Wang, Xiao
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Medicine
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Latent variable models cover a broad range of statistical and machine learning models, such as Bayesian models, linear mixed models, and Gaussian mixture models. Existing methods often suffer from two major challenges in practice: (a) a proper latent variable distribution is difficult to be specified; (b) making an exact likelihood inference is formidable due to the intractable computation. We propose a novel framework for the inference of latent variable models that overcomes these two limitations. This new framework allows for a fully data-driven latent variable distribution via deep neural networks, and the proposed stochastic gradient method, combined with the Langevin algorithm, is efficient and suitable for complex models and big data. We provide theoretical results for the Langevin algorithm, and establish the convergence analysis of the optimization method. This framework has demonstrated superior practical performance through simulation studies and a real data analysis. Supplementary materials for this article are available online.
title: Idioma universal, filiación lingüística e historia americana La filología de Miguel Ángel Mossi
Creators: name: Battista, Emiliano
Publisher: name: Universität Graz
Year: 2022

description: En el presente trabajo analizamos la concepción del lenguaje de Miguel Ángel Mossi, misionero
apostólico italiano de intensa actividad en el escenario intelectual argentino del siglo XIX. Para
ello, dividimos la exposición de acuerdo con tres aspectos que consideramos centrales para comprender
el alcance de su labor filológica: la postulación de un idioma universal subyacente a la diversidad
lingüística (decimonónica), el rol desempeñado por el hebreo en la búsqueda del origen
del lenguaje y, por último, el vínculo entre el quichua y la lengua de Adán para dar cuenta del lugar
de los pueblos americanos en la historia de la humanidad. Según observamos, el recurso a la ciencia
del lenguaje en la obra de Mossi fue básicamente instrumental y estuvo al servicio de una interpretación
(religiosa) con la que procuró sentenciar el origen divino del lenguaje, erigir el hebreo
como lengua matriz y reivindicar – revalorizar o, incluso, redescubrir – la figura del 'indio' (el
Inca) en territorio americano.
description: In this article we analyze the conception of language of Miguel Ángel Mossi, a prolific Italian
apostolic missionary in the Argentine intellectual scene of the 19th century. We focus on three topics
that are central for understanding the scope of his philological work: first, the postulation of a
universal language underlying linguistic diversity, second, the role played by Hebrew in the search
for the origin of language and finally, the link between Quichua and the 'language of Adam',
deemed to account for the role of the American peoples in the history of humanity. The study finds
that the recourse to the science of language in Mossi's work was basically instrumental in the cre -
ation of a (religious) interpretation with which he sought to reject the thesis of a divine origin of
language in order to propose Hebrew as the matrix language and to vindicate – revalue or even rediscover
– the figure of the 'Indian' (the Inca) in the American territory.
description: Studia linguistica romanica 2022.7, 74-97
Dimethyldisulfide - Molecule of the Month December 2013 [Archived version]draft item
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for December 2013 about dimethyldisulfide. It is a pdf archive version of the HTML webpage.
Design and Development of Pedal-Operated Washing Machine for Off-Grid Communities in Developing Countries
Creators: name: Gebregiorgis Berhane Temanu
Publisher: name: Zenodo
Year: 2025

description: In Third World nations like Ethiopia, washing is still a burdensome and tedious exercise, left in most casesto women and children who endure chronic exposure to aggressive chemical surfactants and physicalexhaustion. Lack of electric washing machines due to unaffordability, unstable electricity supply, and poorwater pressure exacerbates the chore. To overcome these challenges, a pedal-powered washing machinehas been created, which can wash up to 12 kg of clothes in one cycle within 20–45 minutes.This revolutionary design addresses the drawbacks of conventional washing, including excessive wear andtear on garments, high expense, long washing times, ergonomic strain, and high water and energy usage.The device is made for sustainability and affordability, employing easily accessible local materials andsimple assembly and repair by local welders. As a functional, low-cost, and eco-friendly solution, thepedal washing machine offers a ground breaking alternative to off-grid and resource-scarce communitiesin developing countries.
Additional file 1 of Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis
Creators: name: Ledesma, Jorge R.
name: Ma, Jianing
name: Zheng, Peng
name: Ross, Jennifer M.
name: Vos, Theo
name: Kyu, Hmwe H.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 1: Supplementary file S1: Data Supplement. Table S1. Characteristics of the studies included in the meta-analysis. Table S2. Search strategies. Table S3. Newcastle-Ottawa quality assessment scale adopted for quality assessment. Figure S1. Sensitivity analysis results (comparing time to incident TB of 2 or 3 months to 6 months or more). Figure S2. Sensitivity analysis results (comparing bacteriologically confirmed TB to clinically confirmed TB). Figure S3. Sensitivity analysis results (comparing all form TB incidence in country of study by < 40 per 100,000 and > 40 per 100,000). Figure S4. Sensitivity analysis results (excluding studies that provided TB preventive treatment). PRISMA-P 2015 Checklist.
1,1,1,2-Tetrafluoroethane (HFC-134a) - Molecule of the Month September 2013 [Archived version]
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for September 2013 about 1,1,1,2-tetrafluoroethane. It is a pdf archive version of the HTML webpage.
Wilkinson's catalyst- Molecule of the Month July 2013 [Archived version]
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for July 2013 about Wilkinson's catalyst. It is a pdf archive version of the HTML webpage.
Broadly inhibiting antineuraminidase monoclonal antibodies induced by trivalent influenza vaccine and H7N9 infection in humans.
Creators: name: Rijal, Pramila
name: Wang, Bei Bei
name: Tiong Kit Tan
name: Schimanski, Lisa
name: Janesch, Philipp
name: Dong, Tao
name: McCauley, John W
name: Daniels, Rodney S
name: Townsend, Alain R
name: Kuan-Ying A Huang
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Infectious Disease
Ecology,Evolution & Ethology

description: The majority of antibodies induced by influenza neuraminidase (NA), like those against hemagglutinin (HA), are relatively specific to viruses isolated within a limited time-window as seen in serological studies and the analysis of many murine monoclonal antibodies (mAbs). We report three broadly reactive human mAbs targeting N1 NA. Two were isolated from a young adult vaccinated with trivalent influenza vaccine (TIV), which inhibited N1 NA from viruses isolated from humans over a period of a hundred years. The third antibody isolated from a child with acute mild H7N9 infection inhibited both group 1 N1 and group 2 N9 NAs. In addition, the antibodies cross-inhibited the N1 NAs of highly pathogenic avian H5N1 influenza viruses. These antibodies are protective in prophylaxis against seasonal H1N1 viruses in mice. This study demonstrates that human antibodies to N1 NA with exceptional cross-reactivity can be recalled by vaccination and highlights the importance of standardizing the NA antigen in seasonal vaccines to offer optimal protection.Importance Antibodies to the influenza NA can provide protection against influenza disease. Analysis of human antibodies to NA lags behind that for HA. We show that human monoclonal antibodies against NA induced by vaccination and infection can be very broadly reactive with the ability to inhibit a wide spectrum of N1 NAs on viruses isolated between 1918 and 2018. This suggests that antibodies to NA may be a useful therapy, and that efficacy of influenza vaccines could be enhanced by ensuring appropriate content of NA antigen.
Phenylbutazone - Molecule of the Month April 2013 [Archived version]
Creators: name: May, Paul
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for April 2013 about phenylbutazone. It is a pdf archive version of the HTML webpage.
Artemisinin - Molecule of the Month May 2013 [Archived version]
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description:
This is the Molecule of the Month entry for May 2013 about artemisinin. It is a pdf archive version of the HTML webpage.
Vaska's Complex - Molecule of the Month February 2013 [Archived version]
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for February 2013 about Vaska's complex. It is a pdf archive version of the HTML webpage.
ISPU American Muslim Poll January 2017: General Population Sample
Creators: name: Institute For Social Policy And Understanding (ISPU)
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Satisfaction with way things are going in country (1); worked with people from your neighborhood to improve community in past 12 months (1); voting and voter registration (5); 2016 presidential election (1); most important policy (1); discrimination in past year (2); bullying (4); reaction to presidential election outcome (10); international travel and borders (3); domestic violence (3); American Muslim leaders should condemn terrorism (1); importance of religion (1); financial donation to religious cause or group in last year (6); Black Lives Matter (1).
Fluoroform- Molecule of the Month January 2013 [Archived version]
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for January 2013 about fluoroform. It is a pdf archive version of the HTML webpage.
ISPU American Muslim Poll January 2017: Muslim and Jewish Sample
Creators: name: Institute For Social Policy And Understanding (ISPU)
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Satisfaction with way things are going in country (1); worked with people from your neighborhood to improve community in past 12 months (1); voting and voter registration (5); 2016 presidential election (1); most important policy (1); discrimination in past year (2); bullying (4); reaction to presidential election outcome (10); international travel and borders (3); domestic violence (3); American Muslim leaders should condemn terrorism (1); importance of religion (1); financial donation to religious cause or group in last year (6); Black Lives Matter (1).
Environmental impact assessment of river valley projects in upper Teesta basin of Eastern Himalaya with special reference to fish conservation: a review
Creators: name: Bhatt, Jay P.
name: Tiwari, Sudha
name: Maharaj K. Pandit
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Teesta river basin in Eastern Himalaya is being subjected to cascade hydropower development. To assess the impacts of this developmental activity on fish fauna of the basin, fish habitats of the four largest tributaries in the basin were selected for the present study. A total of 18 large hydroelectric projects are planned on these rivers. Here, a total of 11 EIAs and 2 carrying capacity studies in Teesta basin were reviewed. Our investigations show that after commissioning all the projects, 52–88% of the free-flowing river stretches will be diverted and 7.6–24% of the riverine ecosystems will be converted into semi lacustrine ecosystems in different rivers. The cascade hydropower development is likely to affect more than 100 fish species. All the EIA reports reviewed have investigated fish species richness, impacts on fish fauna and fishery management plans. EIA studies and management plans, however, do not adequately address important ecological and conservation issues due to various limitations. An integrated fish conservation plan for the upper Teesta basin is suggested in this contribution.
Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin
Creators: name: Cai, Shuwei
name: Li, Xian
name: Pu, Shijie
name: Ma, Xinyu
name: He, Xianru
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect.
Temporal microRNA expression profile of pig peripheral blood during postnatal development
Creators: name: Zhong, Zhijun
name: Zhu, Xingxing
name: Tang, Qianzi
name: Hong, Liang
name: Gu, Yiren
name: He, Zhiping
name: Tao, Xuan
name: Yang, Xuemei
name: Liang, Yan
name: Shen, Linyuan
name: Tan, Ya
name: Zeng, Kai
name: Ying, Sancheng
name: Yang, Yuekui
name: Lei, Yunfeng
name: Wang, Yan
name: Gong, Jianjun
name: Chen, Xiaohui
name: Zhou, Rui
name: Zhu, Li
name: Lv, Xuebin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Gene expression profiles of blood can reflect the physiopathologic status of the immune system. The dynamic microRNA (miRNA) expression profiles of peripheral blood from pigs at different developmental stages, and how differential expression of miRNAs might relate to immune system development, are unknown. In this study, peripheral blood samples taken at five developmental stages were used to construct 15 miRNA libraries (three biological replicates/stage): 0 days (newborn), 30 days (weaning), 60 days (weaned), and 180 and 360 days (puberty). We identified 295 known mature miRNAs. Hierarchical clustering of the miRNA expression profile showed significant differences between individuals at the neonatal and postnatal stages. Functional enrichment analysis revealed that miRNAs differentially expressed between pairwise comparisons of the developmental stages were over-represented in immune-related pathways such as toll-like receptor signaling. The time-course of expression of the over-representated miRNAs exhibited a pattern of steady decline over time, for both the complete miRNA compendium and immune-related miRNAs. We identified six marker miRNAs that were highly negatively correlated with chronologic age and enriched for genes involved in immune-related pathways. This study of a peripheral blood miRNA transcriptome offers insight into immune system development in swine and provides a resource for pig genome annotation.
title: Medición de las relaciones discursivas con eye tracking en español peninsular Límites entre paráfrasis y reformulación a partir del tipo de movimiento ocular
Creators: name: Salameh Jiménez, Shima
Publisher: name: Universität Graz
Year: 2022

description: El presente artículo aporta datos cualitativos y cuantitativos al debate sobre los límites de la refor -
mulación frente a otras categorías (trampa forma-función; Pons 2017). Concretamente, los datos se
centran en la relación existente entre paráfrasis y reformulación, dos funciones discursivas que, si
bien parten de una misma intención comunicativa asociada con la formulación (Antos 2011
[1982]), presentan algunas diferencias en su comportamiento (Pons 2013). En línea con otros estudios
previos, y desde un enfoque teórico-experimental con eye tracking, los resultados obtenidos
reflejan diferentes patrones de procesamiento asociados a cada función; distinción que se repite,
además, al tener en cuenta la presencia o ausencia de un marcador discursivo (en este caso, el reformulador
o sea). Para ello, se analizan la cantidad y tipo de movimientos oculares producidos
(fijaciones, regresiones, sacadas).
description: This paper presents quantitative and qualitative analyses to answer the question how reformulation
and other similar categories can be delimited (form-function tramp; Pons 2017). Specifically, our
data focus on the relationship between paraphrase and reformulation, two functions closely related
to reformulation (Antos 2011 [1982]) which show subtle differences not experimentally studied
until now. In line with previous studies, this paper adopts a theoretical-experimental approach using
eye tracking to identify different processing patterns associated with each function. These differences
are also examined to account for the presence or absence of a discourse marker (specifi -
cally, the Sp. discourse marker o sea) in paraphrases and reformulations. For this purpose, the type
and number of eye movements have been analyzed (fixations, regressions, saccades).
description: Studia linguistica romanica 2022.7, 98-125
Рекомендации Европейского общества кардиологов (ESC),Европейского общества атеросклероза (EAS) по диагностикe и лечению дислипидемий. 2016
Creators: name: Doe, Jonn
Publisher: name: figshare
Year: 2017
Subjects: subject: Cardiology
subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Рекомендации Европейского общества кардиологов (ESC),Европейского общества атеросклероза (EAS) по диагностикe и лечению дислипидемий. 2016
Modélisation des infiltrations d’eau dans les ouvrages souterrains par la méthode des éléments finis à l’aide du logiciel CESAR - LCPC : Application sur un tunnel du métro de Paris
Creators: name: Bouchenafa, Walid
name: Mouhous-Voyneau, Nassima
name: Sergent, Philippe
name: Guillois, Rodolphe
name: Chatzipetrou, Marianna
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Cet article présente une étude qui permet d’estimer le débit d’infiltration rentrant dans un tunnel en fonction de la charge de la nappe phréatique. Nous allons décrire et représenter numériquement et d’une façon détaillée, le flux d’eau entrant dans les tunnels par infiltration liée à la nappe phréatique. Pour cela nous utilisons un modèle de simulation des écoulements souterrains. Nous traitons mathématiquement un problème d’écoulement en milieu poreux non saturé qui jusqu’à présent n’est pas encore bien cerné dans le domaine des écoulements souterrains dans les tunnels de métro. Et enfin, nous appliquerons le modèle retenu sur un tunnel du métro de Paris.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Exploration of mtDNA control region sequences in Chinese Tibetan Mastiffs
Creators: name: Yin-Xia Li
name: Gao, Yi-Long
name: Xing-Liang He
name: Cao, Shao-Xian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 60506 Virology

description: The control region of mitochondrial DNA (mtDNA) was obtained from 40 purebred Chinese Tibetan Mastiffs (TMs). Sequence structure and genetic diversity were analyzed, and a phylogenetic tree was constructed. The TM mtDNA control region was composed of ETAS (extended termination associated sequences), CD (a central domain) and CSBs (conserved sequenced blocks) and sequence length showed some diversity, which was mainly caused by the number of 10 nucleotide repeat units [5′-GTA CAC GT (G/A) C-3′] between CSB I and CSB II, which ranged from 27 to 35 among individuals. Seventy-five polymorphic sites were identified, which defined 37 haplotypes; the haplotype diversity was 0.990, and the nucleotide diversity was 1.201. Based on the control region sequences, Chinese TMs were divided into three categories, which were consistent with the origin and geographical classification of TMs. Phylogenetic analysis of 538-bp HVR-I sequences revealed that TMs were most closely related to Labrador Retrievers.
Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation
Creators: name: Mrinalini Sharma
name: Khageswar Sahu
name: Singh, Surya Prakash
name: Jain, Beena
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences

description: Curcumin is a promising wound healing agent but its clinical application is limited due to hydrophobicity and lack of stability. In this article, we report the results of a study on wound healing efficacy of curcumin conjugated to hyaluronic acid (HA) which is a natural polysaccharide known to influence the healing process. Studies on proliferation, antioxidant activity and scratch wound healing carried out in human keratinocyte cells revealed that HA-conjugated curcumin treatment enhanced cell proliferation, decreased oxidative damage induced by H2O2 and also improved migration of cells in scratch wounds as compared to treatment with native curcumin. HA conjugated curcumin exhibited bactericidal activity in dark and phototoxicity when irradiated with blue light against antibiotic resistant bacteria. Furthermore, wound healing efficacy studied in diabetic mice demonstrated that topical application of the conjugate on wounds led to better healing as compared to treatment with HA-free curcumin and HA alone. These results suggest that HA conjugation is a promising formulation of curcumin for enhancing its healing efficacy.
Chemical Changes during rice storage at metal silo: fatty acid profile changes
Creators: name: Srinivasan K
name: Chidanand D V
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 30199 Analytical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30401 Biologically Active Molecules

description: ABSTRACTObjective: To study the chemical changes of paddy stored at metal silo for a period of 6-month.Methods: The peroxide value (PV) and free fatty acids (FFAs) were analyzed by titrimetry method. The total fatty acid profile was analyzed throughgas chromatography-mass spectrometry (GC-MS) (Scion 436-GC Bruker model coupled with a triple quadrupole mass spectrophotometer) andNational Institute Standard and Technology-MS library.Results: The PV of paddy at the 1st month of storage is 0.62 mEq/kg and at the 6th month the value increases to 5.11 mEq/kg and initial FFA wasrecorded as 0.49% and final value of 2.28%. In accordance with these data, the GC-MS study of rice bran oil (RBO) proved that polyunsaturated fattyacid percentage is decreasing over the period of storage time.Conclusion: With the results and findings, the overall chemical change during the 6-month storage of paddy at metal silo does not affect the RBOquality significantly.
Рекомендации Европейского общества кардиологов (ESC),Европейского общества атеросклероза (EAS) по диагностикe и лечению дислипидемий. 2016.pdf
Creators: name: Doe, Jonn
Publisher: name: figshare
Year: 2017
Subjects: subject: Cardiology
subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Рекомендации Европейского общества кардиологов (ESC),Европейского общества атеросклероза (EAS) по диагностикe и лечению дислипидемий. 2016
Hair cortisol levels and mental health problems in children and adolescents exposed to victimization
Creators: name: Azeredo, Lucas Araújo De
name: Thiago Wendt Viola
name: Rothmann, Leonardo Melo
name: Trentin, Ricardo
name: Arteche, Adriane Xavier
name: Kristensen, Christian Haag
name: Buchweitz, Augusto
name: Grassi-Oliveira, Rodrigo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Youths who experience multiple forms of victimization are at a heightened risk for psychopathology across the lifespan. The hypothalamic-pituitary-adrenal (HPA) axis is a key target for the investigation of neurobiological changes induced by chronic stress and violence exposure. The measurement of hair cortisol concentration allows the investigation of long-term HPA activity and its association with victimization. The present study investigated the impact of exposure to polyvictimization in Latin-American children and adolescents on hair cortisol levels. We investigated association among cortisol, mental health problems and victimization. The study included 83 youths (mean age 10.84 years-old) from southern Brazil. We assessed self-reported victimization scores (Juvenile Victimization Questionnaire - JVQ-R2), mental health problems (Child Behavior Checklist - CBCL/6-18), and hair cortisol concentrations for the previous 30 days. The results showed an association between exposure to multiple forms of victimization and higher concentrations of hair cortisol; the results also showed that cortisol levels and mental health problems were associated with the severity of polyvictimization. These findings suggest that preadolescent victimization is associated with hyperactivation of HPA axis and with increased risk of mental health issues.