cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Determination of human monoclonal antibodies nivolumab and relatlimab in opdualag by using the RP-UPLC technique: method development and validation
Creators: name: Bonam, Sridhar
name: Rao, T. Siva
name: Srinivas, K. Rama
name: Pallapati, Suman
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: A fixed combination of Nivolumab and Relatlimab (OPDUALAG) are human monoclonal antibodies (mAb) that are extensively used to treat skin cancer melanoma. The current investigation is to develop a robust, stability-indicating, and rapid method for the simultaneous determination of these two drugs by using the RP-UPLC technique. By utilizing this technique, the final chromatographic conditions were achieved with a Luna C18 column (50 x 2.1 mm, 1.6 μm), and a mobile phase made with acetonitrile and 0.1% formic acid, 6:4 ratio, respectively (Diluted 1.0 mL of Formic acid in 1000 mL of HPLC grade water) by adapting isocratic elution. Both Nivolumab and Relatlimab were detected at 229 nm, and a satisfactory separation was achieved in 3.0 minutes of run time with a flow rate of 0.2 mL/min. The method is linear from 15 - 90 μg/mL for Nivolumab (R2 = 0.9996) and 5 - 30 μg/mL for Relatlimab (R2 = 0.9997). Results of method repeatability for Nivolumab (% RSD=1.3 %) and Relatlimab (% RSD=0.48 %) and intermediate precision Nivolumab (% RSD=1.1 %) and Relatlimab (% RSD=0.48%) were found within acceptable limits. Also, the forced degradation study results show that it is discernible; the degradation products of both drugs were separated from the main peak, which demonstrates the efficiency of the stability-indicating method. So this method works well for routine analysis and stability studies.
How Have Changes in the Labor Market Contributed to Increases in Suicide and Drug Poisoning Deaths among Men in the United States?
Creators: name: Carroll, Jamie M.
name: Duncombe, Alicia
name: Mueller, Anna S.
name: Muller, Chandra
Publisher: name: University of Texas at Austin Population Research Center
Year: 2022
Subjects: labor market
suicide
drug poisoning deaths
men

description: Over the last two decades, deaths from suicide and drug poisoning have risen rapidly for American men without a college degree. Changes in the U.S. labor market likely play a central role in these mortality patterns. This changing labor market – particularly the loss of good-paying blue-collar jobs – can feed into feelings of hopelessness and despair which in turn increase vulnerability to suicide and drug poisoning deaths. Many adolescents growing up in the 1970s expected to hold blue-collar jobs that would support middle-class lifestyles but found that these jobs had largely disappeared when they reached adulthood. Using data from a large, nationally‐representative sample of students who were in high school in 1980, PRC researcher Jamie Carroll, PRC faculty scholar Chandra Muller, and colleagues, find that men who expected to work in occupations that later declined in labor market share and economic value have increased risks of suicide and drug poisoning deaths in adulthood. They advocate for educational training in flexible skills and adaptability as important tools for suicide and drug abuse prevention.
Vertebrate preferential intracellular pH regulation during severe acute hypercarbia
Creators: name: Shartau, Ryan Brady
Publisher: name: University of British Columbia
Year: 2017

description: Environmental CO2 tensions reach >8 kPa (ca. 79,000 μatm; hypercarbia) in some habitats and create severe acid-base challenges for vertebrates. Typically, during a hypercarbic-induced respiratory acidosis, changes in blood pH are compensated for, which returns pH to its normal value, and this is coupled to tissue pH (pHi) regulation. However, during acute environmental CO₂ exposure, this process may be limited to <2 kPa PCO₂. Some fishes fully protect tissue pH (pHi) (preferential pHi regulation) despite large sustained reductions of pHe (>1 pH unit) and can tolerate PCO₂ >3 kPa. I hypothesized that preferential pHi regulation is used by adult fishes and embryonic amniotes during severe acute acid-base disturbances. This was investigated by examining (1) whether preferential pHi regulation is a general response to various types of acid-base disturbances, (2) surveying fishes for the presence or absence of preferential pHi regulation, and (3) whether preferential pHi regulation is used during development in reptiles. Using white sturgeon, I found that preferential pHi regulation is not a general response to both respiratory and metabolic acidoses. Despite a robust capacity for preferential pHi regulation during respiratory acidoses, not all tissues were protected during metabolic acidoses to the same degree. Preferential pHi regulation was observed to be a common pattern of acid-base regulation amongst fishes in response to severe acute hypercarbia. A total of 20 species, ranging from basal (“primitive”) to derived, were examined and 18 were observed to use preferential pHi regulation. Finally, developing amniotes (snapping turtle and American alligator) used preferential pHi regulation during severe acute respiratory acidosis, but the capacity for pHi regulation was progressively reduced throughout development. This thesis demonstrates that preferential pHi regulation is likely a common strategy of acid-base regulation occurring in response to severe acute hypercarbia in adult fishes and possibly amniotes. I propose that preferential pHi regulation is an embryonic vertebrate strategy, that has been retained or lost in adults depending on the environmental acid-base challenges they face.
Laser cooling of a potassium-argon gas mixture using collisional redistribution of radiation
Creators: name: Saß, Anne
name: Vogl, Ulrich
name: Weitz, Martin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We study laser cooling of atomic gases by collisional redistribution, a technique applicable to ultradense atomic ensembles at a pressure of a few hundred bar. Frequent collisions of an optically active atom with a buffer gas shift atoms into resonance with a far red detuned laser beam, while spontaneous decay occurs close to the unperturbed resonance frequency. In such an excitation cycle, a kinetic energy of the order of the thermal energy kT is extracted from the sample. Here we report of recent experiments investigating the cooling of a potassium-argon gas mixture, which compared to an rubidium-argon mixture investigated in earlier experiments has a smaller fine structure of the optically active alkali atom. We observe a relative cooling of the potassium-argon gas mixture by 120 K.
description: 4 figures
Torsionswirkungen der Schuhsohlenrolle: eine biomechanische Betrachtung [ = Torsion effects of shoe soles. A biomechanical viewpoint]
Creators: name: Grifka, Joachim
Publisher: name: Universität Regensburg
Year: 1986
Subjects: subject: 610 Medizin
subject: Ankle Joint/physiology
subject: Biomechanics
subject: Foot/physiology
subject: Gait
subject: Humans
subject: Shoes/standards
subject: Torsion Abnormality

description: Requirements concerning the location of the top of shoe-sole rolls are formulated on the basis of the physiological sequence of movements in the step, the aim being to ensure a functionally correct sequence of movements, corresponding to the condition to be treated. Special attention should be paid to adverse torsion effects caused by inappropriate positioning of the rolls, since the torsion has negative effect on the gait pattern.
Efficient Synthesis of 3,4-Dihydropyrimidin-2-ones in Low Melting Tartaric Acid – Urea Mixtures
Creators: name: Gore, S.
name: Baskaran, S.
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 540 Chemie

description: A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as a novel reaction medium. The melt plays a triple role: as solvent, as catalyst and as reactant, furnishing highly functionalized dihydropyrimidinones in good to excellent yields.
Loose packings of frictional spheres
Creators: name: Farrell, Greg R.
name: Martini, K. Michael
name: Menon, Narayanan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We have produced loose packings of cohesionless, frictional spheres by sequential deposition of highly-spherical, monodisperse particles through a fluid. By varying the properties of the fluid and the particles, we have identified the Stokes number (St) - rather than the buoyancy of the particles in the fluid - as the parameter controlling the approach to the loose packing limit. The loose packing limit is attained at a threshold value of St at which the kinetic energy of a particle impinging on the packing is fully dissipated by the fluid. Thus, for cohesionless particles, the dynamics of the deposition process, rather than the stability of the static packing, defines the random loose packing limit. We have made direct measurements of the interparticle friction in the fluid, and present an experimental measurement of the loose packing volume fraction, ϕ_{RLP}, as a function of the friction coefficient μ_s.
description: 6 pages, 5 figures
Microstructure, vacancies and moments of nuclear magnetic resonance of hydrogenated amorphous silicon
Creators: name: Biswas, Parthapratim
name: Timilsina, Rajendra
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Recent experiments on hydrogenated amorphous silicon using infrared absorption spectroscopy have indicated the presence of mono- and divacancy in samples for concentration of up to 14\% hydrogen. Motivated by this observation, we study the microstructure of hydrogen in two model networks of hydrogen-rich amorphous silicon with particular emphasis on the nature of the distribution (of hydrogen), the presence of defects, and the characteristic features of the nuclear magnetic resonance spectra at low and high concentration of hydrogen. Our study reveals the presence of vacancies, which are the built-in features of the model networks. The study also confirms the presence of various hydride configurations in the networks that include from silicon monohydrides and dihydrides to open chain-like structures, which have been observed in the infrared and nuclear magnetic resonance experiments. The broad and the narrow line widths of the nuclear magnetic resonance spectra are calculated from a knowledge of the distribution of spins (hydrogen) in the networks.
description: 15 pages, 16 figures
Grundsätzliche Probleme der Versorgung mit funktionellen Knieorthesen [= Basic problems in the treatment with functional knee orthoses]
Creators: name: Grifka, Joachim
name: Jutka, H.
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: Adult
subject: Braces
subject: Equipment Design
subject: Female
subject: Humans
subject: Knee Injuries/rehabilitation
subject: Knee Joint/physiology
subject: Male
subject: Materials Testing
subject: Range of Motion, Articular

description: An indication for functional knee-orthoses is given especially with ACL-insufficiency and after ACL-operations. Analyses of biomechanical examinations demonstrate difficulties in realizing the joint movement of the knee in detail and imitating it with knee-orthoses. An anamnestic investigation and clinical examination of sportsmen and -women, using functional knee-orthoses due to ACL-insufficiency (24 Lenox-Hill, 25 C.Ti., 38 Donjoy), demonstrate problems in practical usage of these orthoses. Problems especially arise from dislocation of the orthoses' joints and a deficient protection against anterior tibial translation. Thus leading to evident giving-way events though using a knee brace in 68% of these cases. In the tested knee-orthotic-devices problems in usage are independent of the kind of mechanical joints of the orthoses. The clinical examination should prove an application of the orthosis without pressure and only little distal dislocation.
A numerical development in the dynamical equations of solitons into ideal optical fibers
Creators: name: de Queiroz, Diogo Albino
name: Natti, Paulo Laerte
name: Romeiro, Neyva Maria Lopes
name: Natti, Érica Regina Takano
Publisher: name: arXiv
Year: 2010
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Numerical Analysis (math.NA)
subject: Optics (physics.optics)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We develop and evaluate a numerical procedure for a system of nonlinear differential equations, which describe the propagation of solitons into ideal dielectric optical fibers. This problem has analytical solutions known. The numerical solutions of the system is implemented by the finite element method, using methods of stabilization such as Streamline Upwind Petrov-Galerkin (SUPG) and Consistent Approximate Upwind (CAU). Comparing the numerical and analytical solutions, it was found that the numerical procedure adequately describes the dynamics of this system.
description: In Portuguese
Selective photocatalytic reductions of nitrobenzene derivatives using PbBiO2X and blue light
Creators: name: Füldner, Stefan
name: Pohla, Patrick
name: Bartling, Hanna
name: Dankesreiter, Stephan
name: Stadler, Roland
name: Gruber, Michael
name: Pfitzner, Arno
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 540 Chemie
subject: 610 Medizin

description: Blue light irradiation of heterogeneous photocatalysts PbBiO2X (X = Cl, Br) in the presence of triethanolamine as an electron donor leads to hydrogen evolution, and the selective, clean and complete reduction of nitrobenzene derivatives to their corresponding anilines.
Quality by design approach in the formulation of vaginal tablet of fluconazole solid dispersion
Creators: name: Kanojiya, Pranita S.
name: Wadetwar, Rita N.
name: Godbole, Amita P.
name: Gawande, Nilesh P.
name: Dadmal, Samiksha S.
name: Fasate, Adesh L.
name: Karad, Chandu B.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Vaginal Candidiasis had caused quite frequent gynecological medical consultations. Fluconazole is an antifungal drug that has poor solubility that hinders dissolution and antifungal activity. The study aimed to formulate the sustained release vaginal tablet of Fluconazole solid dispersion through the Design of Experiment approach to guarantee no compromise with the quality. In the first step, Plackett Burman Design was employed for the preliminary screening of the essential factors that would affect the tablet’s property. The significant factors were used further in applying the 32 factorial design and the responses were studied. The drug release, bioadhesive strength and swelling index were taken as the responses and considered as the vital critical quality attributes of the vaginal tablet. The design space was determined through the contour and response surface plots. The tablet was prepared within the design space with the drug release (99.97±0.1%), bioadhesive strength (1671.62±43.23 dynes/cm2), and swelling index (342.47±5 %) that suggested the values lie within the quality target product profile determined previously. The antifungal activity against C. albicans resulted in a larger inhibition zone for the solid dispersion-based tablet (51±3 mm) than the plain drug-based tablet (36±2 mm).
How fast do charged particles get dressed ?
Creators: name: Leitenstorfer, A.
name: Huber, Rupert
name: Tauser, F.
name: Brodschelm, A.
Publisher: name: Universität Regensburg
Year: 2003
Subjects: subject: 530 Physik
subject: 42.65.Re
subject: 72.15.Lh
subject: 72.30.+q
subject: 78.47.+p

description: On a femtosecond timescale, we observe how Coulomb screening and collective scattering build up in an extreme nonequilibrium electron–hole plasma photoinjected in GaAs. To this end, we generate a plasma within 10 fs and probe the subsequent polarization response of the system with uncertainty-limited temporal resolution via ultrabroadband THz spectroscopy. We show that the intrinsic material becomes conductive instantaneously upon carrier injection, whereas collective effects such as Coulomb screening and plasmon scattering exhibit a delayed onset. Thus, the ultrafast formation of dressed quasiparticles is directly monitored for the first time. The timescale for these phenomena is of the order of the inverse plasma frequency. Our findings support recent quantum kinetic simulations.
A Massive Molecular Gas Reservoir in the z=5.3 Submillimeter Galaxy AzTEC-3
Creators: name: Riechers, Dominik A.
name: Capak, Peter L.
name: Carilli, Christopher L.
name: Cox, Pierre
name: Neri, Roberto
name: Scoville, Nicholas Z.
name: Schinnerer, Eva
name: Bertoldi, Frank
name: Yan, Lin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We report the detection of CO 2-1, 5-4, and 6-5 emission in the highest-redshift submillimeter galaxy (SMG) AzTEC-3 at z=5.298, using the Expanded Very Large Array and the Plateau de Bure Interferometer. These observations ultimately confirm the redshift, making AzTEC-3 the most submillimeter-luminous galaxy in a massive z=5.3 protocluster structure in the COSMOS field. The strength of the CO line emission reveals a large molecular gas reservoir with a mass of 5.3e10 (alpha_CO/0.8) Msun, which can maintain the intense 1800 Msun/yr starburst in this system for at least 30 Myr, increasing the stellar mass by up to a factor of six in the process. This gas mass is comparable to `typical' z~2 SMGs, and constitutes >~80% of the baryonic mass (gas+stars) and 30%-80% of the total (dynamical) mass in this galaxy. The molecular gas reservoir has a radius of <4 kpc and likely consists of a `diffuse', low-excitation component, containing (at least) 1/3 of the gas mass (depending on the relative conversion factor alpha_CO), and a `dense', high-excitation component, containing ~2/3 of the mass. The likely presence of a substantial diffuse component besides highly-excited gas suggests different properties between the star-forming environments in z>4 SMGs and z>4 quasar host galaxies, which perhaps trace different evolutionary stages. The discovery of a massive, metal-enriched gas reservoir in a SMG at the heart of a large z=5.3 protocluster considerably enhances our understanding of early massive galaxy formation, pushing back to a cosmic epoch where the Universe was less than 1/12 of its present age.
description: 6 pages, 5 figures, to appear in ApJL (accepted August 2, 2010)
Adjacency-Preserving Spatial Treemaps
Creators: name: Buchin, Kevin
name: Eppstein, David
name: Löffler, Maarten
name: Nöllenburg, Martin
name: Silveira, Rodrigo I.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computational Geometry (cs.CG)
subject: FOS: Computer and information sciences

description: Rectangular layouts, subdivisions of an outer rectangle into smaller rectangles, have many applications in visualizing spatial information, for instance in rectangular cartograms in which the rectangles represent geographic or political regions. A spatial treemap is a rectangular layout with a hierarchical structure: the outer rectangle is subdivided into rectangles that are in turn subdivided into smaller rectangles. We describe algorithms for transforming a rectangular layout that does not have this hierarchical structure, together with a clustering of the rectangles of the layout, into a spatial treemap that respects the clustering and also respects to the extent possible the adjacencies of the input layout.
The ADHM Variety and Perverse Coherent Sheaves
Creators: name: Jardim, Marcos
name: Martins, Renato Vidal
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We study the full set of solutions to the ADHM equation as an affine algebraic set, the ADHM variety. We gather the points of the ADHM variety into subvarieties according to the dimension of the stabilizing subspace. We compute dimension, and analyze singularity and reducibility of all of these varieties. We also connect representations of the ADHM quiver to coherent perverse sheaves on $\mathbb{P}^2$ in the sense of Kashiwara.
description: 19 pages.
Biological and computational studies of novel scaffolds of gallic acid: insight from density functional theory and molecular docking studies
Creators: name: Hijazi, Shariqah
name: Ahmed, Nayeem
name: Louis, Hitler
name: Anna, Imojara
name: Shah, Wajaht A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: In this study, we carried out the isolation of gallic acid from Hippophae rhamnoides plant followed by synthetic modification by using Dicyclohexyl carbodimide (DCC) as a coupling reagent. The synthetic modification involves the amidation of Gallic acid by a one-step protocol, converting gallic acid to its corresponding amide derivatives. The reactions involve a simple one-pot procedure with the formation of a chain of scaffolds of various beneficial amides in good to outstanding yields. The synthesized amides were characterized by several spectroscopic techniques like FTIR, HNMR, and Mass spectrometry. The synthetic derivatives were theoretically studied by Density Functional Theory (DFT) and their biological structural feasibility was studied by docking studies. Moreover, the antibacterial activities of the derivatives were also evaluated, and it is worthwhile to mention that all compounds have shown good antibacterial activity with the highest inhibition zone of 21 mm (A2) against strains of gram-positive and gram-negative bacteria with MIC value of 40 mg/mL.
Estimation of C II and C II* column densities along Galactic sight-lines
Creators: name: Parvathi, Veena S.
name: Sofia, Ulysses J.
name: Murthy, Jayant
name: Babu, B. R. S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present interstellar C II (1334.5323 Å) and C II* (1335.7077 Å) column density measurements along 14 Galactic sight-lines. These sight-lines sample a variety of Galactic disk environments and include paths that range nearly two orders of magnitude in average hydrogen densities () along the lines of sight. Five of the sight-lines show super-Solar gas phase abundances of carbon. Our results show that the excess carbon along these sight-lines may result from different mechanisms taking place in the regions associated with these stars.
description: 9 pages, 3 figures; Accepted for publication in BASI
Horse sense: social status of horses (Equus caballus) affects their likelihood of copying other horses’ behavior
Creators: name: Krueger, Konstanze
name: Heinze, Jürgen
Publisher: name: Universität Regensburg
Year: 2008
Subjects: subject: 590 Tiere (Zoologie)

description: Animals that live in stable social groups need to gather information on their own relative position in the group’s social hierarchy, by either directly threatening or by challenging others, or indirectly and in a less perilous manner, by observing interactions among others. Indirect inference of dominance relationships has previously been reported from primates, rats, birds, and fish. Here, we show that domestic horses, Equus caballus, are similarly capable of social cognition. Taking advantage of a specific ‘‘following behavior’’ that horses show towards humans in a riding arena, we investigated whether bystander horses adjust their response to an experimenter according to the observed interaction and their own dominance relationship with the horse whose reaction to the experimenter they had observed before. Horses copied the ‘‘following behavior’’ towards an experimenter after watching a dominant horse following but did not follow after observing a subordinate horse or a horse from another social group doing so. The ‘‘following behavior,’’ which horses show towards an experimenter, therefore appears to be affected by the demonstrator’s behavior and social status relative to the observer.
On Parametric Vector Optimization via Metric Regularity of Constraint Systems
Creators: name: Durea, Marius
name: Strugariu, Radu
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90C30, 49J53, 54C60

description: Some metric and graphical regularity properties of generalized constraint systems are investigated. Then, these properties are applied in order to penalize (in the sense of Clarke) various scalar and vector optimization problems. This method allows us to present several necessary optimality conditions in solid constrained vector optimization.
description: 14 pages
On the Origin of the Extended Halpha Filaments in Cooling Flow Clusters
Creators: name: McDonald, Michael
name: Veilleux, Sylvain
name: Rupke, David S. N.
name: Mushotzky, Richard
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present a high spatial resolution Halpha survey of 23 cooling flow clusters using the Maryland Magellan Tunable Filter (MMTF), covering 1-2 orders of magnitude in cooling rate, dM/dt, temperature and entropy. We find 8/23 (35%) of our clusters have complex, filamentary morphologies at Halpha, while an additional 7/23 (30%) have marginally extended or nuclear Halpha emission, in general agreement with previous studies of line emission in cooling flow cluster BCGs. A weak correlation between the integrated near-UV luminosity and the Halpha luminosity is also found for our complete sample, with a large amount of scatter about the expected relation for photoionization by young stars. We detect Halpha emission out to the X-ray cooling radius, but no further, in several clusters and find a strong correlation between the Halpha luminosity contained in filaments and the X-ray cooling flow rate of the cluster, suggesting that the warm ionized gas is linked to the cooling flow. Furthermore, we detect a strong enhancement in the cooling properties of the ICM coincident with the Halpha emission, compared to the surrounding ICM at the same radius. While the filaments in a few clusters may be entrained by buoyant radio bubbles, in general, the radially-infalling cooling flow model provides a better explanation for the observed trends. The correlation of the Halpha and X-ray properties suggests that conduction may be important in keeping the filaments ionized. The thinness of the filaments suggests that magnetic fields are an important part of channeling the gas and shielding it from the surrounding hot ICM.
description: Accepted for publication in ApJ, 52 pages, 16 figures, 2 tables
Current challenges in business and IT alignment
Creators: name: Khodabandeh Amiri, Amin
Publisher: name: University of British Columbia
Year: 2019

description: This dissertation addresses two current challenges in IT-Business alignment. The first study introduces a new type of operational alignment, namely capacity alignment, and addresses how it becomes a threat to the success and survival of organizations. Taking a grounded theory (GT) approach, the study started with a quest for answering how IT unavailability becomes a strategic risk. While there exist many unavailability incidents with no strategic consequences, anecdotal evidence suggests that some unavailability incidents have caused negative strategic impacts on organizations. Twenty-six cases of IT unavailability with strategic consequences, along with two cases with non-strategic consequences, were studied. The analysis of cases revealed that IT unavailability is, in fact, a capacity misalignment rather than an IT outage suggested by extant literature. Moreover, a system dynamic view of IT unavailability was developed to help clarify how IT capacity misalignment becomes a strategic risk. Unfortunately, the existing classic GT as well as its interpretivist extensions are inconsistent with the way positivist researchers view and test theories. Therefore, the dissertation had to customize classic GT to develop an IT unavailability theory compatible with a positivist ontology of theories. As well, the revised methodology ensures that conclusions from data have a higher chance of reproducibility by other researchers and datasets. This strengthens the accuracy of GT that Burton-Jones and Lee (2017) called for and ensures that the theory is grounded in data rather than researchers. The second study addresses improving strategic alignment through CIO’s language. Shared language between CIO and top management team— one of the most powerful antecedents of alignment— has been neglected by the extant literature. The purpose of this study was to prescribe guidance for CIOs regarding the language that should be used in a conversation with top managers about the strategic role of IT. Leveraging the literature on strategic management, the study suggests applying the nomenclature of theories of the resource-based view and the capability-based view instead of technical language. An experiment was conducted to evaluate the effectiveness of these languages in terms of the antecedents of strategic alignment. The study suggests which language should be used in which conditions.
Novel electrosensory advertising during diurnal resting period in male snoutfish, Marcusenius altisambesi (Mormyridae, Teleostei)
Creators: name: Machnik, Peter
name: Kramer, Bernd
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: Electric organ discharge; Electrocommunication; Reproductive cycle; Sexual attraction; Male advertisement signal; Regularized discharge pattern
subject: 570 Biowissenschaften, Biologie
subject: 590 Tiere (Zoologie)

description: During the day, weakly electric snoutfish, such as Marcusenius altisambesi from the Okavango delta, avoid visually oriented predators by hiding in sheltered, dark places where they discharge their electric organs at a low and variable rate, interspersed with occasional short bursts (mean discharge rate, 4–12 Hz). Hence, histograms of inter-discharge intervals (IDI) are broad and bimodal (IDI range, about 15–500 ms; “variable IDI pattern”). We report here that with a female neighbor in electrical communication reach, captive males of M. altisambesi (N = 4) each showed a novel type of IDI resting pattern that was characterized by a higher and more constant discharge rate (16–28 Hz). These IDI histograms were unimodal and narrow (IDI range, about 11–100 ms; “regularized IDI pattern”). In each of these males, the regularized pattern vanished when the female neighbors were replaced by males, and the common variable IDI pattern of low rate was observed instead. In an unforced choice paradigm, six M. altisambesi experimental females were allowed to choose between two electric fish decoys, one playing back the novel regularized IDI pattern and one playing back the variable IDI pattern. Five experimental females significantly preferred staying close to the decoy playing back the regularized IDI pattern, whereas one female showed the opposite preference. It appears that males advertise to females during their diurnal period of overt inactivity, with an inconspicuous signal that neither threatens conspecifics nor alerts predators by overt behavior. A secondary function of the regularized male IDI pattern could be to advance the reproductive cycle of females.
Characterising Tumour Intrinsic And Microenvironmental Determinants Of Melanoma Progression Within Lymph Nodes
Creators: name: Leece, Isobel Anne Murrell
Publisher: name: Monash University
Year: 2025
Subjects: classificationCode: 320404
subject: Cellular immunology
classificationCode: 321101
subject: Cancer cell biology
classificationCode: 320407
subject: Innate immunity
classificationCode: 300104
subject: Genetically modified animals
classificationCode: 320409
subject: Tumour immunology

description: Melanoma, a serious skin cancer, often spreads to lymph nodes (LNs). LNs are responsible for generating an anti-tumour response, but how metastasis to the LN affects the immune system remains unclear. This study examined changes in immune cells within melanoma-invaded LNs from patients and developed a model for this disease in mice. Anti-tumour immune cells were found at the tumour border in patient LNs, but did not influence survival. In mice, two new melanoma cell lines with different genetic features were developed. Both lines spread to lymph nodes and triggered immune responses. These findings could guide future immunotherapy development.
Gold on graphene as a substrate for surface enhanced Raman scattering study
Creators: name: Wang, Yingying
name: Ni, Zhenhua
name: Hu, Hailong
name: Hao, Yufeng
name: Wong, Choun Pei
name: Yu, Ting
name: Thong, John TL
name: Shen, Ze Xiang
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this paper, we report our study on gold (Au) films with different thicknesses deposited on single layer graphene (SLG) as surface enhanced Raman scattering (SERS) substrates for the characterization of rhodamine (R6G) molecules. We find that an Au film with a thickness of ~7 nm deposited on SLG is an ideal substrate for SERS, giving the strongest Raman signals for the molecules and the weakest photoluminescence (PL) background. While Au films effectively enhance both the Raman and PL signals of molecules, SLG effectively quenches the PL signals from the Au film and molecules. The former is due to the electromagnetic mechanism involved while the latter is due to the strong resonance energy transfer from Au to SLG. Hence, the combination of Au films and SLG can be widely used in the characterization of low concentration molecules with relatively weak Raman signals.
description: 11 pages, 4 figures
Design of Finite-Length Irregular Protograph Codes with Low Error Floors over the Binary-Input AWGN Channel Using Cyclic Liftings
Creators: name: Asvadi, Reza
name: Banihashemi, Amir H.
name: Ahmadian-Attari, Mahmoud
Publisher: name: arXiv
Year: 2011
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences
subject: Information Theory

description: We propose a technique to design finite-length irregular low-density parity-check (LDPC) codes over the binary-input additive white Gaussian noise (AWGN) channel with good performance in both the waterfall and the error floor region. The design process starts from a protograph which embodies a desirable degree distribution. This protograph is then lifted cyclically to a certain block length of interest. The lift is designed carefully to satisfy a certain approximate cycle extrinsic message degree (ACE) spectrum. The target ACE spectrum is one with extremal properties, implying a good error floor performance for the designed code. The proposed construction results in quasi-cyclic codes which are attractive in practice due to simple encoder and decoder implementation. Simulation results are provided to demonstrate the effectiveness of the proposed construction in comparison with similar existing constructions.
description: Submitted to IEEE Trans. Communications
Local control of a single nitrogen-vacancy center by nanoscale engineered magnetic domain wall motions
Creators: name: McLaughlin, Nathan J.
name: Li, Senlei
name: Brock, Jeffrey A.
name: Zhang, Shu
name: Lu, Hanyi
name: Huang, Mengqi
name: Xiao, Yuxuan
name: Zhou, Jingcheng
name: Tserkovnyak, Yaroslav
name: Fullerton, Eric E.
name: Wang, Hailong
name: Du, Chunhui Rita
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Effective control and readout of qubits form the technical foundation of next-generation, transformative quantum information sciences and technologies. The nitrogen-vacancy (NV) center, an intrinsic three-level spin system, is naturally relevant in this context due to its excellent quantum coherence, high fidelity of operations, and remarkable functionality over a broad range of experimental conditions. It is an active contender for the development and implementation of cutting-edge quantum technologies. Here, we report magnetic domain wall motion driven local control and measurements of NV spin properties. By engineering the local magnetic field environment of an NV center via nanoscale reconfigurable domain wall motions, we show that NV photoluminescence, spin level energies, and coherence time can be reliably controlled and correlated to the magneto-transport response of a magnetic device. Our results highlight the electrically tunable dipole interaction between NV centers and nanoscale magnetic structures, providing an attractive platform to realize interactive information transfer between spin qubits and non-volatile magnetic memory in hybrid quantum spintronic systems.
description: 13 pages, 5 figures
Olfactory Recognition of Individual Competitors by Means of Faeces in Horse (Equus caballus)
Creators: name: Krueger, Konstanze
name: Flauger, Birgit
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: equids, faecal samples, horse, olfaction, sociality
subject: 590 Tiere (Zoologie)

description: Living in complex social systems requires perceptual and cognitive capacities for the recognition of group membership and individual competitors. Olfaction is one means by which this can be achieved. Many animals can identify individual proteins in urine, skin secretions, or saliva by scent. Additionally, marking behaviour in several mammals and especially in horses indicates the importance of sniffing conspecifics’ faeces for olfactory recognition. To test this hypothesis, we conducted two separate experiments: Experiment one addressed the question of whether horses can recognize the group membership of other horses by sniffing their faeces. The horses were presented with four faecal samples: 1) their own, 2) those of other members of their own group, 3) those of unfamiliar mares, and 4) those of unfamiliar geldings. Experiment two was designed to assess whether horses can identify the group member from whom a faecal sample came. Here, we presented two groups of horses with faecal samples from their group mates in random distribution. As controls, soil heaps and sheep faecal samples were used. In experiment one, horses distinguished their own from their conspecifics’ faeces, but did not differentiate between familiarity and sex. In experiment two, the horses from both groups paid most attention to the faeces of the horses from which they received the highest amount of aggressive behaviours. We therefore suggest that horses of both sexes can distinguish individual competitors among their group mates by the smell of their faeces.
Behaviour of Horses in the “Round Pen Technique”
Creators: name: Krueger, Konstanze
Publisher: name: Universität Regensburg
Year: 2007
Subjects: subject: earning, dominance relationship, horse, human-animal relationships
subject: 590 Tiere (Zoologie)

description: I investigated the behavioural background of the way horses learn to follow humans in the “round pen technique” suggested by "horse whisperers” as a gentle method for initial horse training. Though the practicability of this technique has been adequately demonstrated in the past, the horses‘ behaviour during such training has not yet been documented in detail. DIn a riding arena, horses, that did not follow the trainer immediately, were chased away so that they galloped around the trainer. Galloping horses showed specific behaviour such as turning the ear to the trainer, chewing, licking, and stretching head and throat downwards. In subsequent trials horses needed to be chased for less time and finally followed immediately, even when conditions were changed or the trainer was replaced by another person. This suggests that horses learn to follow in this particular situation and also show some generalisation. However, following did not occur on a pasture even after several successful trials in the riding arena.
A New 24 micron Phase Curve for upsilon Andromedae b
Creators: name: Crossfield, Ian J.
name: Hansen, Brad M. S.
name: Harrington, Joseph
name: Cho, James Y-K.
name: Deming, Drake
name: Menou, Kristen
name: Seager, Sara
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the detection of 24 micron variations from the planet-hosting upsilon Andromedae system consistent with the orbital periodicity of the system's innermost planet, upsilon And b. We find a peak-to-valley phase curve amplitude of 0.00130 times the mean system flux. Using a simple model with two hemispheres of constant surface brightness and assuming a planetary radius of 1.3 Jupiter radii gives a planetary temperature contrast of >900 K and an orbital inclination of >28 degrees. We further report the largest phase offset yet observed for an extrasolar planet: the flux maximum occurs ~80 degrees before phase 0.5. Such a large phase offset is difficult to reconcile with most current atmospheric circulation models. We improve on earlier observations of this system in several important ways: (1) observations of a flux calibrator star demonstrate the MIPS detector is stable to 10^-4 on long timescales, (2) we note that the background light varies systematically due to spacecraft operations, precluding use of this background as a flux calibrator (stellar flux measured above the background is not similarly affected), and (3) we calibrate for flux variability correlated with motion of the star on the MIPS detector. A reanalysis of our earlier observations of this system is consistent with our new result.
description: Submitted to ApJ. 15 pages, 6 figures, 4 tables
Broadband terahertz study of excitonic resonances in the high-density regime in GaAs∕AlxGa1−xAs quantum wells
Creators: name: Huber, Rupert
name: Kaindl, R. A.
name: Schmid, B. A.
name: Chemla, D. S.
Publisher: name: Universität Regensburg
Year: 2005
Subjects: subject: 530 Physik
subject: 78.47.+p
subject: 73.20.Mf
subject: 78.67.De

description: We report the first terahertz study of the intraexcitonic 1s-2p transition at high excitation densities in GaAs∕AlxGa1−xAs quantum wells. A strong shift, broadening, and ultimately the disappearance of this resonance occurs with increasing density, after ultrafast photoexcitation at the near-infrared exciton line. Densities of excitons and unbound electron-hole pairs are followed quantitatively using a model of the composite terahertz dielectric response. Comparison with near-infrared absorption changes reveals a significantly enhanced energy shift and broadening of the intraexcitonic resonance.
description: » This publication has been selected for the Virtual Journal of Ultrafast Science
Integrable quantum spin chains and their classical continuous counterparts
Creators: name: Avan, Jean
name: Doikou, Anastasia
name: Sfetsos, Konstadinos
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We present certain classical continuum long wave-length limits of prototype integrable quantum spin chains, and define the corresponding construction of classical continuum Lax operators. We also provide two specific examples, i.e. the isotropic and anisotropic Heisenberg models.
description: 15 pages Latex. Proceedings contribution to the Corfu Summer Institute on Elementary Particle Physics and Gravity - Workshop on Non Commutative Field Theory and Gravity, 8-12 September 2010, Corfu, Greece
Enhanced Publications -- Wie Forschungsbibliotheken innovative Publikationsformen unterstützen
Creators: name: Bargheer, Margo
Publisher: name: Zenodo
Year: 2019

description: This is the introduction to a Hands-On workshop at the German Bibliothekartag. https://opus4.kobv.de/opus4-bib-info/frontdoor/index/index/start/0/rows/20/sortfield/score/sortorder/desc/searchtype/simple/query/bargheer/yearfq/2019/docId/16393
description: Andrea Bertino has helped in shaping the ideas and was the main author of the abstract.
Femtosecond Buildup of a Many-Body Resonance Observed via Two-Dimensional THz Time-Domain Spectroscopy
Creators: name: Huber, Rupert
name: Tauser, F.
name: Brodschelm, A.
name: Leitenstorfer, A.
Publisher: name: Universität Regensburg
Year: 2002
Subjects: subject: 530 Physik
subject: 42.65.Re
subject: 72.15.Lh
subject: 72.30.+q
subject: 78.47.+p

description: In a non-equilibrium electron–hole plasma photoexcited in GaAs within 10 fs, we observe how a plasmon pole builds up on a femtosecond time scale. To this end, the dynamics of the complex dielectric function throughout the mid-infrared is probed with uncertainty-limited temporal resolution by means of ultrabroadband THz spectroscopy. We show that collective effects, such as plasma oscillations, exhibit a delayed onset. This observation may be linked to the ultrafast formation of dressed quasiparticles in the many-body system. The approximate time scale for these phenomena is found to be of the order of the inverse plasma frequency. Thus, our findings support quantum kinetic models of the temporal evolution of the Coulomb interaction after ultrafast carrier generation in semiconductors. These theories have been co-pioneered by R. Zimmermann and his coworkers around the beginning of the last decade.
Active disturbance rejection control for unmanned tracked vehicles in leader-follower scenarios: discrete-time implementation and field test validation
Creators: name: Amokrane, Salem-Bilal
name: Laidouni, Mohammed Zouaoui
name: Adli, Touati
name: Madonski, Rafal
name: Stanković, Momir
Publisher: name: arXiv
Year: 2023
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents a systematic design of an active disturbance rejection control (ADRC) system for unmanned tracked vehicles (UTVs) in leader-follow formation. Two ADRC controllers are designed for the lateral and the longitudinal channels of the UTV based on control errors in the cross-track and the along-track directions. Through simulations, the proposed ADRC approach is first shown to outperform the conventional PI/PID controllers in scenarios involving sudden changes in the leader motion dynamics, slippage disturbances, and measurement noise. Then, a comprehensive experimental validation of the proposed leader-follower control is performed using a laboratory UTV equipped with a camera and laser sensors (to enable the calculation of error signals). In order to provide more effective interaction between the human (leader) and the UTV (follower) during the leader-follower task, a camera-based subsystem for human pose recognition is developed and deployed. Finally, the experimental results obtained outdoors demonstrate that the proposed ADRC-based leader-follower UTV control system achieves high tracking capabilities, robustness against slippage disturbances, and adaptability to changing environmental conditions.