cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Preparation and characterisation of lignin nanoparticles: evaluation of their potential as antioxidants and UV protectants
Creators: name: Yearla, Srinivasa Rao
name: Kollipara Padmasree
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Lignin, an abundant plant biopolymer, is known to possess antioxidant and UV protectant properties in its native state. Nanoparticles exhibit either improved or different properties corresponding to their bulk materials or parent polymers. In the present study, using nanoprecipitation method, dioxane lignin nanoparticles (DLNP) and alkali lignin nanoparticles (ALNP) are fabricated from two different sources of lignin, i.e., hardwood dioxane lignin (DL) extracted from subabul stems and softwood alkali lignin (AL) which is available as a commercial source. Both DLNP and ALNP were fabricated in spherical shape with mean size of 80–104 nm. Analysis of radical scavenging activity revealed that both DLNP and ALNP possess higher antioxidant activity when compared with their parent polymers DL and AL, respectively. UV protectant potential of DLNP and ALNP was validated by monitoring the survival rates of Escherichia coli upon UV-induced mortality. DLNP and ALNP were more efficient than DL and AL in protecting E. coli against UV-irradiation-induced mortality. However, upon irradiation for different time periods, DLNP offered pronounced protection for E. coli against UV when compared with ALNP. Thus, the present study demonstrates that the antioxidant and UV protection properties of DLNP can be exploited further in food, pharmaceutical and cosmetic industries.
Siberian river water tracer on the 1027.8 isopyncal surface from 1/12 degree NEMO model simulation
Creators: Paul Myers
Publisher: name: University of Alberta Library
Year: 2024

Animation of the thickness of a Siberian river water tracer, projected onto the 1027.8 isopyncal surface, in metres (using a logarithmic scale), based on a 1/12 degree NEMO model simulation of the Arctic and North Atlantic (ANHA12-ECP024).
title: Возраст несовершеннолетней жертвы преступления как фактор, влияющий на организационно-тактические особенности проведения процессуальных действий при расследовании ятрогенных преступлений
Creators: name: Лавриненко, Александра
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Жертвы ятрогенных преступлений, совершенных в отношении несовершеннолетних, обладают физиологическими, психологическими и коммуникативными особенностями, которые находятся в прямой зависимости от их возраста. Эта специфика оказывает влияние на организационно-тактические аспекты проведения процессуальных действий в ходе расследования ятрогенных преступлений. Так, например, одной из основных задач осуществления процессуальных действий в данном случае является минимизация воздействия на несовершеннолетнего травмирующих стрессообразующих факторов, которое может негативно отразиться на его психологическом состоянии. Специфические признаки несовершеннолетней жертвы и субъекта ятрогенных преступлений как элементы криминалистической характеристики позволяют выделить ятрогенные преступления, совершенные в отношении несовершеннолетних, в отдельную классификационную группу преступлений.
Coherent interaction of atoms with a beam of light confined in a light cage
Creators: name: Davidson-Marquis, Flavie
name: Gargiulo, Julian
name: Gómez-López, Esteban
name: Jang, Bumjoon
name: Kroh, Tim
name: Müller, Chris
name: Ziegler, Mario
name: Maier, Stefan A.
name: Kübler, Harald
name: Schmidt, Markus
name: Benson, Oliver
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: 530 Physik

description: Controlling coherent interaction between optical fields and quantum systems in scalable, integrated platforms is essential for quantum technologies. Miniaturised, warm alkali-vapour cells integrated with on-chip photonic devices represent an attractive system, in particular for delay or storage of a single-photon quantum state. Hollow-core fibres or planar waveguides are widely used to confine light over long distances enhancing light-matter interaction in atomic-vapour cells. However, they suffer from inefficient filling times, enhanced dephasing for atoms near the surfaces, and limited light-matter overlap. We report here on the observation of modified electromagnetically induced transparency for a non-diffractive beam of light in an on-chip, laterally-accessible hollow-core light cage. Atomic layer deposition of an alumina nanofilm onto the light-cage structure was utilised to precisely tune the high-transmission spectral region of the light-cage mode to the operation wavelength of the atomic transition, while additionally protecting the polymer against the corrosive alkali vapour. The experiments show strong, coherent light-matter coupling over lengths substantially exceeding the Rayleigh range. Additionally, the stable non-degrading performance and extreme versatility of the light cage provide an excellent basis for a manifold of quantum-storage and quantum-nonlinear applications, highlighting it as a compelling candidate for all-on-chip, integrable, low-cost, vapour-based photon delay.
Keck spectroscopy and imaging of globular clusters in the lenticular galaxy NGC 524
Creators: name: Beasley, Michael A.
name: Forbes, Duncan
name: Brodie, Jean
name: Kissler-Patig, Markus
Publisher: name: Swinburne
Year: 2024

description: We have obtained Keck Low-Resolution Imaging Spectrometer imaging and spectra for 29 globular clusters associated with the lenticular galaxy NGC 524. Using the empirical calibration of Brodie & Huchra we find that our spectroscopic sample spans a metallicity range of −2.0 ≤[Fe/H]≤ 0 . We have compared the composite spectrum of the metal-poor ([Fe/H] < −1) and metal-rich clusters with stellar population models in order to estimate the ages of the NGC 524 globular clusters. We conclude that the clusters are generally old, and are coeval at the 2σ confidence level. To determine the mean [α/Fe] ratios of the globular clusters, we have employed the Milone et al. α-enhanced stellar population models. We verified the reliability of these models by comparing them with high signal-to-noise Galactic globular cluster spectra. We observe a weak trend of decreasing [α/Fe] ratios with increasing metallicity in the NGC 524 clusters; the metal-poor clusters possess [α/Fe]∼0.3, whilst the metal-rich clusters exhibit [α/Fe] ratios closer to solar-scaled values. Analysis of the cluster system kinematics reveals that the full sample (excluding an outlying cluster) exhibits a rotation of 114 ± 60 km s−1 around a position angle of 22°± 27° , and a velocity dispersion of 186 ± 29 km s−1 at a mean radius of 89 arcsec from the galaxy centre. Subdividing the clusters into metal-poor and metal-rich subcomponents (at [Fe/H]=−1.0 ), we find that the metal-poor (17) clusters and metal-rich (11) clusters have similar velocity dispersions ( 197 ± 40 and 169 ± 47 km s−1 , respectively). However, the metal-poor clusters dominate the rotation in our sample with 147 ± 75 km s−1 , whilst the metal-rich clusters show no significant rotation (68 ± 84 km s−1) . We derive a virial and projected mass estimation for NGC 524 of between 4 and 13 × 1011 M⊙ (depending on the assumed orbital distribution) interior to ∼2 effective radii of this galaxy.
Does NEP-2020 Work as a Disciplinary Measure for Students? An Issue Needs Global Attention
Creators: name: Dr. Dibakar Sarangi, Mr. Gajanana Behera
Publisher: name: Zenodo
Year: 2024

description: Student indiscipline in educational institutions has been an everyday problem for all stakeholders, obstructing the teaching and learning process and increasing instructor stress levels. This issue has presented challenges to both skilled and untrained teachers. The objective of this paper is to elaborate on the disciplinary issue from a global perspective and its causes. The paper focuses on Charles' (2014) theory of behavioural disorders.  Furthermore, this paper attempted to justify the key role of NEP-2020 in enriching disciplined behavior among students. This paper also stated the importance of discipline for students and how discipline can be enriched through NEP 2020 where students will be given new ways of learning through multifarious disciplines. It focuses on respect for diversity and respect for the local context in all curriculum, pedagogy, and policy. This paper also revealed how NEP 2020 ensured inclusive and equitable quality education at all levels of school education and higher education including access to education. School should implement student friendly and flexible curriculum and pedagogical methods to ensure discipline among learners. This paper proposed for educational implications like a common standard for both public and private schools should be maintained to ensure uniformity among students. Focus should be given on equity while education for socially and economically disadvantaged section is imparted. School curriculum should be designed in such a manner that will imbibe the human values among students.
title: Некоторые проблемы защиты жилищных прав несовершеннолетних членов семьи
Creators: name: Миролюбова, Ольга
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Статья посвящена анализу основных проблем реализации и защиты права пользования жилым помещением несовершеннолетними членами семьи собственника. В частности, автор затрагивает проблемы
обеспечения жилищных интересов несовершеннолетних в случае расторжения брака их родителей. Особого внимания заслуживают вопросы применения и совершенствования норм семейного законодательства,
направленных на защиту жилищных прав ребенка, в частности, новой редакции статьи 86 Семейного кодекса РФ. Автор анализирует норму п. 4 ст. 292 Гражданского кодекса РФ и приходит к выводу о необходимости
возвращения ей охранной функции. Представляет интерес проблема неопределенности правового положения ребенка, приобретающего производное право пользования жилым помещением (например, в случае
вселения его членом семьи собственника). Новизна работы заключается в исследовании элементов жилищно-правового статуса ребенка с позиций его комплексного правового регулирования.
Determining Aerosol Volatility Parameters Using a “Dual Thermodenuder” System: Application to Laboratory-Generated Organic Aerosols
Creators: name: Provat K. Saha
name: Khlystov, Andrey
name: Grieshop, Andrew P.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Molecular Biology
subject: Engineering
subject: Biophysics

description: Thermodenuders (TD) are a tool widely used for measuring aerosol volatility in the laboratory and field. Extracting the parameters that dictate organic aerosol volatility from TD data is challenging because gas-particle partitioning rarely reaches equilibrium inside a TD operating under atmospheric conditions, thus a wide variety of parameter sets can explain observed evaporation. Component volatilities (as represented by saturation vapor pressure, Csat), cannot be directly extracted due to uncertainties in potential limitations to mass transfer (represented by mass accommodation coefficient, α) and components’ enthalpies of evaporation (ΔHvap). To address these limitations, we have developed a “dual TD” experimental approach in which one line uses a temperature-stepping TD (TS-TD) with a relatively long residence time (RT) and the other operates isothermally at variable residence time (VRT-TD). Data from this approach are used in tandem with an optimizing evaporation kinetics model to extract the values of parameters dictating volatility (Csat, and associated values of ΔHvap and α). The system was evaluated using laboratory generated dicarboxylic acid aerosols (adipic acid and succinic acid). Excellent agreement with previously published evaporation data collected with other TD systems was observed. Parameter values reported in the literature for the tested acids vary widely, but our results are generally consistent with those from studies that allow for nonunity values of α. For example, our results suggest that α for these aerosols are of order 0.1, in agreement with results determined by Saleh et al. (2009, 2012). Modeling results suggest that the addition of VRT-TD data provides tighter constraint on feasible ΔHvap and α values. The dual TD approach presented here does not rely on equilibration in the TD and thus can be directly applied to extract volatility parameters for more complex laboratory and ambient organic aerosol systems.Copyright 2015 American Association for Aerosol Research
title: Foreign Direct Investments In Africa’s Food And Agriculture Sector
title: How understanding and channeling FDI better could unlock a powerful development tool
titleType: AlternativeTitle
Creators: name: Baraké, Evelyn
name: Husmann, Christine
name: Kubik, Zaneta
Publisher: name: Center for Development Research (ZEF)
Year: 2019
Subjects: subject: Africa
subject: Investment
subject: Agricultural production
subject: Food processing
subject: Employment
subject: ddc:330
subject: ddc:630

description: Despite African governments’ efforts to attract Foreign Direct Investment (FDI) into their food and agriculture sector and the counter-criticism this has provoked, surprisingly little research has been conducted to better understand the scale and impact of these investments. Such information is crucial to be able to harness FDI as a tool for poverty reduction and development, including where investments flow, what drives them, and their long-term effects on the local population.
 Related research at ZEF has highlighted a number of key insights:
 - FDI flows into Africa’s food and agriculture sector come from diverse sources and are less concentrated than is often thought.
 - FDI projects in the food and agriculture sector are implemented mainly to serve local and regional markets.
 - Areas with larger supplies of agricultural land, higher population density, better infrastructure, regulatory quality and previous investment projects are more likely to attract FDI in this sector.
Combined organic matter and nitrogen removal from a chemical industry wastewater in a two-stage MBBR system
Creators: name: S.M.S. Cao
name: G.A.T. Fontoura
name: M. Dezotti
name: J.P. Bassin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biotechnology
subject: Cell Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Engineering

description: Pesticide-producing factories generate highly polluting wastewaters containing toxic and hazardous compounds which should be reduced to acceptable levels before discharge. In this study, a chemical industry wastewater was treated in a pre-denitrification moving-bed biofilm reactor system subjected to an increasing internal mixed liquor recycle ratio from 2 to 4. Although the influent wastewater characteristics substantially varied over time, the removal of chemical oxygen demand (COD) and dissolved organic carbon was quite stable and mostly higher than 90%. The highest fraction of the incoming organic matter was removed anoxically, favouring a low COD/N environment in the subsequent aerobic nitrifying tank and thus ensuring stable ammonium removal (90–95%). However, during pH and salt shock periods, nitrifiers were severely inhibited but gradually restored their full nitrifying capability as non-stressing conditions were reestablished. Besides promoting an increase in the maximum nitrification potential of the aerobic attached biomass from 0.34 to 0.63 mg , the increase in the internal recycle ratio was accompanied by an increase in nitrogen removal (60–78%) and maximum specific denitrification rate (2.7–3.3 mg ). Total polysaccharides (PS) and protein (PT) concentrations of attached biomass were observed to be directly influenced by the influent organic loading rate, while the PS/PT ratio mainly ranged from 0.3 to 0.5. Results of Microtox tests showed that no toxicity was found in the effluent of both the anoxic and aerobic reactors, indicating that the biological process was effective in removing residual substances which might adversely affect the receiving waters' ecosystem.
title: Faire l'Europe par la culture
title:  Europäisierung durch Kultur
title: Liber Amicorum François Genton
titleType: Subtitle
Creators: name: OTT, Herta-Luise
name: Rimasson-Fertin, Natacha
name: Nicklas, Thomas
Publisher: name: Editions et presses universitaires de Reims
Year: 2021
Subjects: subject: FOS: Humanities
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: The European Union is a unique institutional construction in history. Built and enlarged slowly and peacefully, with the aim of reconciling sworn enemies after two terrible wars by means of an economic alliance designed to create a lasting human understanding, it is today much more than a simple free trade area. What about European culture? How does it relate to the continent's economic and political integration projects? Constantly under development, constantly questioned, even contested, European culture is the subject of the studies gathered in this volume.
description: L’Union européenne est un édifice institutionnel unique dans l’histoire. Construite et élargie lentement et pacifiquement, dans le but de réconcilier après deux guerres terribles des ennemis jurés par un rapprochement économique destiné à fonder durablement une entente humaine, elle représente aujourd’hui bien plus qu’une simple zone de libre-échange. Et la culture européenne ? Comment s’articule-t-elle aux projets d’intégration économique et politique du continent ? Constamment en construction, sans cesse interrogée, voire contestée, la culture européenne fait l’objet des études réunies dans ce volume.
Combined organic matter and nitrogen removal from a chemical industry wastewater in a two-stage MBBR system
Creators: name: S.M.S. Cao
name: G.A.T. Fontoura
name: M. Dezotti
name: J.P. Bassin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biotechnology
subject: Cell Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Engineering

description: Pesticides producing factories generates highly polluting wastewaters containing toxic and hazardous compounds which should be reduced to acceptable levels before discharge. In this study, a chemical industry wastewater was treated in a pre-denitrification moving-bed biofilm reactor system subjected to increasing internal mixed liquor recycle ratio from 2 to 4. Although the influent wastewater characteristics substantially varied over time, the removal of chemical oxygen demand (COD) and dissolved organic carbon (DOC) were quite stable and mostly higher than 90%. The highest fraction of the incoming organic matter was removed anoxically, favouring a low COD/N environment in the subsequent aerobic nitrifying tank and thus ensuring stable ammonium removal (90–95%). However, during pH and salt shock periods, nitrifiers were severely inhibited but gradually restored their full nitrifying capability as non-stressing conditions were reestablished. Besides promoting an increase in the maximum nitrification potential of the aerobic attached biomass from 0.34 to 0.63 mg NH4+-N/(gVAS.h), the increase in the internal recycle ratio was accompanied by an increase in nitrogen removal (60 to 78%) and maximum specific denitrification rate (2.7 to 3.3 mg NOx−-N/(gVAS.h)). Total polysaccharides (PS) and protein (PT) concentrations of attached biomass were observed to be directly influenced by the influent organic loading rate, while the PS/PT ratio mainly ranged from 0.3 to 0.5. Results of Microtox tests showed that no toxicity was found in the effluent of both the anoxic and aerobic reactors, indicating that the biological process was effective in removing residual substances which might adversely affect the receiving waters ecosystem.Supplemental Material
nacento.sk - tvorba cenových ponúk pre stavebné firmy
Creators: name: Adrián, Hochla
Publisher: name: Zenodo
Year: 2023

description: Stavebné firmy obdržia dokumentáciu rodinného domu, najčastejšie v PDF formáte, a ich úlohou je ponúknuť položkovo rozpísanú cenu za dohodnuté služby. Môže ísť o rôzne služby, v závislosti od dostupných financií zákazníka, ale spravidla ide buď o výstavbu základovej dosky, hrubej stavby, strechy alebo celého domu nakľúč. Problémov pri ponúknutí detailnej cenovej ponuky za tieto služby je niekoľko. Aby firma vedela presne určiť cenu každej práce a dodávky každého materiálu, musí analyzovať premenné, ktoré vstupujú do týchto cien. Sú to napríklad lokalita stavby, jej rozmer a svahovitosť, výskyt nosných prvkov a priečok. Ďalej potrebujú presný výpis materiálov ako objem betónu, výkopovej zeminy, počty a rozmery debniacich tvárnic, počty murovacích tehál, ktorý si väčšinou počítajú sami. Potrebujú tiež ľahko upraviteľný a prehľadný formát cenovej ponuky, ktorý je čo najviac do detailu rozpísaný na jednotlivé položky. Je to preto, že cenová ponuka je prvým reprezentatívnym faktorom firmy v očiach zákazníka. Kvalita cenovej ponuky je preto, nehľadiac na samotnú cenu, najdôležitejším faktorom určenia dôveryhodnosti firmy.
The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux
Creators: name: Wiersma, Valerie R
name: Bruyn, Marco De
name: Yunwei Wei
name: Ginkel, Robert J Van
name: Mitsuomi Hirashima
name: Niki, Toshiro
name: Nishi, Nozomu
name: Zhou, Jin
name: Pouwels, Simon D
name: Samplonius, Douwe F
name: Nijman, Hans W
name: Eggleton, Paul
name: Helfrich, Wijnand
name: Bremer, Edwin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Evolutionary Biology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRASmut) CRC is uniquely sensitive to treatment with recombinant LGALS9/Galectin-9 (rLGALS9), a recently established regulator of epithelial polarity. Upon treatment of CRC cells, rLGALS9 rapidly internalizes via early- and late-endosomes and accumulates in the lysosomal compartment. Treatment with rLGALS9 is accompanied by induction of frustrated autophagy in KRASmut CRC, but not in CRC with BRAF (B-Raf proto-oncogene, serine/threonine kinase) mutations (BRAFmut). In KRASmut CRC, rLGALS9 acts as a lysosomal inhibitor that inhibits autophagosome-lysosome fusion, leading to autophagosome accumulation, excessive lysosomal swelling and cell death. This antitumor activity of rLGALS9 directly correlates with elevated basal autophagic flux in KRASmut cancer cells. Thus, rLGALS9 has potent antitumor activity towards refractory KRASmut CRC cells that may be exploitable for therapeutic use.
title: Ausländische Direktinvestitionen im Nahrungsmittel- und Agrarsektor Afrikas
title: Wie ein besseres Verständnis und eine bessere Ausrichtung von Investitionen ein leistungsfähiges Entwicklungswerkzeug freisetzen könnten
titleType: AlternativeTitle
Creators: name: Baraké, Evelyn
name: Husmann, Christine
name: Kubik, Zaneta
Publisher: name: Center for Development Research (ZEF)
Year: 2019
Subjects: subject: Africa
subject: Investment
subject: Agricultural production
subject: Food processing
subject: Employment
subject: ddc:330

description: Trotz der Bemühungen der afrikanischen Regierungen, ausländische Direktinvestitionen (DI) in ihren Nahrungsmittel- und Agrarsektor anzuziehen, und der damit verbundenen Gegenkritik wurden überraschend wenig Untersuchungen durchgeführt, um das Ausmaß und die Auswirkungen dieser Investitionen besser zu verstehen. Diese Informationen sind von entscheidender Bedeutung, um ausländische Direktinvestitionen als Instrument zur Armutsbekämpfung und Entwicklung nutzen zu können, insbesondere wohin Investitionen fließen, was sie antreibt und welche langfristigen Auswirkungen sie auf die lokale Bevölkerung haben.
 Forschung, die zu diesem Thema am ZEF durchgeführt wurde, hat eine Reihe von Schlüsselerkenntnissen hervorgebracht:
 - Die ausländischen DI-Ströme in den afrikanischen Nahrungsmittel- und Agrarsektor stammen aus verschiedenen Quellen und sind weniger konzentriert als oft angenommen wird.
 - Ausländische DI-Projekte im Nahrungsmittel- und Agrarsektor werden hauptsächlich zur Bedienung lokaler und regionaler Märkte durchgeführt.
 - Gebiete mit einem größeren Angebot an landwirtschaftlichen Flächen, einer höheren Bevölkerungsdichte, einer besseren Infrastruktur, besseren Regularien und bestehenden Investitionsprojekten werden eher ausländische Direktinvestitionen in diesem Sektor anziehen.
The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux
Creators: name: Wiersma, Valerie R
name: Bruyn, Marco De
name: Yunwei Wei
name: Ginkel, Robert J Van
name: Mitsuomi Hirashima
name: Niki, Toshiro
name: Nishi, Nozomu
name: Zhou, Jin
name: Pouwels, Simon D
name: Samplonius, Douwe F
name: Nijman, Hans W
name: Eggleton, Paul
name: Helfrich, Wijnand
name: Bremer, Edwin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Evolutionary Biology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRASmut) CRC is uniquely sensitive to treatment with recombinant LGALS9/Galectin-9 (rLGALS9), a recently established regulator of epithelial polarity. Upon treatment of CRC cells, rLGALS9 rapidly internalizes via early- and late-endosomes and accumulates in the lysosomal compartment. Treatment with rLGALS9 is accompanied by induction of frustrated autophagy in KRASmut CRC, but not in CRC with BRAF (B-Raf proto-oncogene, serine/threonine kinase) mutations (BRAFmut). In KRASmut CRC, rLGALS9 acts as a lysosomal inhibitor that inhibits autophagosome-lysosome fusion, leading to autophagosome accumulation, excessive lysosomal swelling and cell death. This antitumor activity of rLGALS9 directly correlates with elevated basal autophagic flux in KRASmut cancer cells. Thus, rLGALS9 has potent antitumor activity toward refractory KRASmut CRC cells that may be exploitable for therapeutic use.
title: Преступность несовершеннолетних в Новгородской губернии второй половины XIX в. (по данным губернского Статистического комитета)
Creators: name: Митина, Светлана
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Статья посвящена анализу уголовно-правовой политики в отношении несовершеннолетних в России во второй половине XIX в. В статье анализируется нормативная основа уголовной ответственности несовершеннолетних в Российской империи, характеризуются этапы её развития.
На основе данных Статистического комитета Новгородской губернии и отчетов урядников автор раскрывает состояние преступности несовершеннолетних и мер государственного принуждения к правонарушителям. Автор характеризует тенденцию разграничения в рамках уголовно-правового статуса несовершеннолетних отдельных возрастных групп, анализирует социальные и экономические причины роста преступности.
Keck spectroscopy of globular clusters in the Sombrero galaxy
Creators: name: Larsen, Søren S.
name: Brodie, Jean
name: Beasley, Michael A.
name: Forbes, Duncan
Publisher: name: Swinburne
Year: 2024

description: We analyze high signal-to-noise spectra for 14 globular clusters (GCs) in the Sombrero galaxy, NGC 4594 (= M104), obtained with the LRIS spectrograph on the Keck I telescope. We find generally good agreement between spectroscopic metallicities and previous photometric metallicities based on V-I colors. Further, we use measurements of various Balmer line indices on co-added spectra of metal-poor and metal-rich GCs to estimate ages for the GC subpopulations and find ages of 10-15 Gyr, with preferred ages around 11-12 Gyr and no detectable differences between the metal-rich and metal-poor subpopulations. However, because of model and measurement uncertainties, age differences of a few (2-3) gigayears cannot be ruled out. We also measure α-to-iron abundance ratios from Mg and TiO features and find enhancements on the order of [α/Fe] ∼ +0.4, similar to the [α/Fe] abundance ratios observed in other old stellar populations. Finally, we combine our sample with radial velocities for 34 GCs from Bridges et al. and obtain virial and projected masses for the Sombrero of MVT = (8.1 ± 1.8) × 1011 M ⊙ and MP = (5.3 ± 1.0) × 1011 M⊙ within 17 kpc, respectively. Using 12 clusters within the central 4.5 kpc the corresponding numbers are MVT = (2.1 ± 1.1) × 1011 M⊙ and MP = (2.0 ± 1.3) × 1011M⊙.
ORFs_seq_insecticide_resistance
Creators: name: Libro, Pietro
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310206
subject: Sequence analysis
classificationCode: 310204
subject: Genomics and transcriptomics
classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified
classificationCode: 310201
subject: Bioinformatic methods development

description: Insecticide resistance represents a major threat for the control of insect vectors. In last years, genetically-based tools have been proposed as a cutting-edge alternative to counteract this problem. However, high-quality -omics resources are crucial for an effective application of these tools. Here, we presented a de novo transcriptome of the mosquito vector Culex pipiens, assembled by using sequences of susceptible and diflubenzuron-resistant individuals. A total of 437,233,732 reads were assembled and annotated and the high-quality of the assemblage was confirmed by TransRate and BUSCO. A mapping percentage until 94.8% was obtained by aligning contigs to Nr, SwissProt, and TrEMBL, with 27,281 sequences that simultaneously mapped on the three databases. A total of 14,966 ORFs were also functionally annotated by using the eggNOG database. A comparison through the orthologues with other five mosquito species further validated the quality of the Cx. pipiens transcriptome. This resource represents therefore a valuable reference for further investigations about mosquito biology, their adaptation to insecticides, as well as to identify target sequences for genetic-based control tools.
title: How to keep tractors running in Africa?
title: Lessons for knowledge and skills development from Zambia
titleType: AlternativeTitle
Creators: name: Thoelen, Jan
name: Daum, Thomas
Publisher: name: Center for Development Research (ZEF)
Year: 2019
Subjects: subject: Africa
subject: Agricultural production
subject: Mechanization
subject: Skill development
subject: ddc:330

description: Successful agricultural mechanization requires building knowledge and skills of machinery owners, operators and technicians on how to manage, run, maintain and repair machinery. Building such knowledge and skills still remains a major bottleneck in most African countries. A study in Ghana has found that 80% of the tractor-owners regularly face long breakdowns due to a lack of knowledge and skills. But what kinds of knowledge and skills are needed? And what are the most appropriate ways to build them? This policy brief presents some answers based on a comprehensive study on the knowledge and skill requirements for machinery owners and operators in Zambia.
CONTINUED ADVANCEMENTS IN TREATMENT PROTOCOLS, VACCINATION EFFORTS, AND UNDERSTANDING LONG COVID-19.
Creators: name: Aziza Abdullah Alabdullatif, Eman Salman Alsafwani, Fatimah Mohammed Al-Hay,  Khadija Ali Alkhamis
Publisher: name: Zenodo
Year: 2021

description: Background: Advancements in treatment protocols, vaccination efforts, and understanding of long COVID have been pivotal in addressing the ongoing challenges posed by the COVID-19 pandemic. Long COVID, characterized by persistent symptoms following SARS-CoV-2 infection, has emerged as a significant public health concern. Research has focused on understanding its epidemiology, pathophysiology, and potential interventions. 

Aim: This overview explores the advancements in treatment protocols, vaccination, and long-term care of COVID-19

Methods: This comprehensive review uses PUBMED and Google Scholar as primary databases for articles collected until March 2021.

Conclusion: The COVID-19 pandemic, stemming from zoonotic transmission in Wuhan, has become a major global health crisis highlighting the need for international collaboration in health management. Progress in treatments and vaccination efforts, while significant, requires continued commitment to address challenges and enhance support for those affected by the virus and its long-term impacts.

Keywords: Covid – Treatment – long term care.
Keck imaging of the globular cluster systems in the early-type galaxies NGC 1052 and 7332
Creators: name: Forbes, Duncan
name: Georgakakis, Antonis E.
name: Brodie, Jean
Publisher: name: Swinburne
Year: 2024

description: The presence of two globular cluster subpopulations in early-type galaxies is now the norm rather than the exception. Here we present two more examples for which the host galaxy appears to have undergone a recent merger. Using multi-colour Keck imaging of NGC 1052 and 7332 we find evidence for a bimodal globular cluster colour distribution in both galaxies, with roughly equal numbers of blue and red globular clusters. The blue ones have similar colours to those in the Milky Way halo and are thus probably very old and metal-poor. If the red globular cluster subpopulations are at least of solar metallicity, then stellar population models indicate young ages. We discuss the origin of globular clusters within the framework of formation models. We conclude that recent merger events in these two galaxies have had little effect on their overall globular cluster systems. We also derive globular cluster density profiles, global specific frequencies and, in the case of NGC 1052, radial colour gradients and azimuthal distribution. In general these globular cluster properties are normal for early-type galaxies.
Humanities and Data: towards a community driven path towards openness
Creators: name: Giglia, Elena
name: Biro, Timea
Publisher: name: Zenodo
Year: 2020
Subjects: FAIR data, Social Sciences and Humanities, SSH, Open Science, EOSC, OPERAS, Co-OPERAS

description: In the Humanities, data are difficult to define and all the more so to be properly curated and managed. They can be small and smart, rich and complex, non-standardised in format, without common or consistent metadata and ontologies, and can be subject to complex rights issues. Machine readable tools and materials are rarely available and often incomplete or non-interoperable. We are presenting the ongoing works and the preliminary outputs of two complementary initiatives, the CO-OPERAS Implementation Network within GoFAIR and the ALLEA e-Humanities Working Group, two initiatives focusing on community needs and supporting the development of practical recommendations for best practices and services that enable the integration of the long tail of Humanities into the EOSC and more widely to adopt Open Science practices. Our conversation will focus on discussing what data are in the Humanities, identifying the main challenges in the path towards FAIRness and providing recommendations for the digital humanities community.
A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites
Creators: name: Arce, Esteban Rodríguez
name: Sarniguet, Cynthia
name: Moraes, Tania S.
name: Vieites, Marisol
name: A. Isabel Tomaz
name: Medeiros, Andrea
name: Comini, Marcelo A.
name: Varela, Javier
name: Cerecetto, Hugo
name: González, Mercedes
name: Marques, Fernanda
name: M. Helena García
name: Otero, Lucía
name: Gambino, Dinorah
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: As part of our efforts to develop organometallic ruthenium compounds bearing activity on both trypanosomatid parasites and tumor cells, a new Ru(II)–cyclopentadienyl clotrimazole complex, [RuCp(PPh3)2(CTZ)](CF3SO3), where Cp = cyclopentadienyl, CTZ = clotrimazole, was synthesized and characterized. The compound was evaluated in vitro on T. cruzi (Y strain), the infective form of T. brucei brucei strain 427 (cell line 449), on three human tumor cell lines with different sensitivity to cisplatin (A2780, ovary; MCF7, breast; HeLa, cervix) and on J774 murine macrophages as mammalian cell model. The new compound is more cytotoxic on T. cruzi and on the tumor cell lines than the reference drugs (Nifurtimox and cisplatin, respectively). In addition, complexation of the bioactive CTZ to the {RuCp(PPh3)} moiety leads to significant increase of the antiparasitic and antitumoral activity. To get insight into the potential “dual” mechanism of antiparasitic action emerging from the presence of Ru(II) and CTZ in a single molecule, the inhibitory effect of this new complex on the biosynthesis of T. cruzi sterols of membrane and the interaction with DNA were studied. Although the tested complex does not affect DNA, it affects the T. cruzi biosynthetic pathway of conversion of squalene to squalene oxide. According to the results reported here, [RuCp(PPh3)2(CTZ)][CF3SO3] could be considered a prospective antiparasitic and/or antitumoral agent that deserves further evaluation.
title: Luzerne :
title: Richtlinien für die Durchführung der Prüfung auf Unterscheidbarkeit, Homogenität und Beständigkeit.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2005

description: Zweck dieser Richtlinien („Prüfungsrichtlinien“) ist es, die in der Allgemeinen Einführung (Dokument TG/1/3) und deren verbundenen TGP-Dokumenten enthaltenen Grundsätze in detaillierte praktische Anleitung für die harmonisierte Prüfung der Unterscheidbarkeit, der Homogenität und der Beständigkeit (DUS) umzusetzen und insbesondere geeignete Merkmale für die DUS-Prüfung und die Erstellung harmonisierter Sortenbeschreibungen auszuweisen.
title: La Confession et le Texte licencieux
title: Pratiques textuelles et éditoriales dans l'Europe du XVIIIe siècle
titleType: Subtitle
Creators: name: Meise, Helga
name: Haquette, Jean-Louis
Publisher: name: Editions et presses universitaires de Reims
Year: 2020
Subjects: subject: FOS: Languages and literature
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: The present volume examines, from a comparative perspective, the textual practices of confession that characterise a number of eighteenth-century libertine, licentious and pornographic texts published in England, Holland, France and the German-speaking countries. This type of enunciation, in the context of a printed publication, is based on a tension between sexual intimacy and collective dissemination through the book: this exhibition of intimacy is constitutive of the pleasure aimed at by this type of text, but it obviously encounters the social norms of literary representation. Sometimes repressed, often tolerated, this literature has a wide European circulation. Three aspects are highlighted: the role that the texts reserve for confession, the impact of control practices by the public authorities, and the reception and circulation of the texts among the readership.
description: Le présent volume se propose d’étudier dans une perspective comparatiste les pratiques textuelles mettant en scène la confession ou l’aveu, qui caractérisent un certain nombre de textes libertins, licencieux ou pornographiques du XVIIIe siècle, publiés en Angleterre, en Hollande, en France et dans les pays germanophones. Ce type d’énonciation, dans le contexte d’une publication imprimée, repose sur une tension entre l’intimité sexuelle et la diffusion collective par le livre : cette exhibition de l’intime est constitutive du plaisir visé par ce genre de textes, mais elle rencontre évidemment les normes sociales de la représentation littéraire. Parfois supprimée, souvent tolérée, cette littérature connaît une large diffusion européenne. Même si la lecture individuelle restaure un effet d’intimité, le passage par la sphère éditoriale publique joue donc un rôle dans l’architecture de ces récits. Trois aspects sont mis en valeur : le rôle que les textes réservent à la mise en scène des aveux et de la confession, l’impact des pratiques de contrôle par les autorités publiques, la réception et la circulation des textes auprès du lectorat.
ИССЛЕДОВАНИЕ НАНОМАТЕРИАЛОВ МЕТОДАМИ ПРОСВЕЧИВАЮЩИЙ ЭЛЕКТРОННЫЙ МИКРОСКОПИИ
Creators: name: Каюмов, Х.
Publisher: name: Zenodo
Year: 2024

description: Электронный микроскоп — это прибор, предназначенный для просмотра и фотографирования объектов с увеличением до 106 раз. В целом принцип работы оптического микроскопа и электронного микроскопа одинаков. Оптический микроскоп представляет собой систему, состоящую из световых лучей и стеклянных линз, меняющих свое направление. В электронном микроскопе вместо световых лучей это пучок высокоэнергетических электронов, ускоренных в глубоком вакууме, а для изменения направления этих электронов используются электромагнитные линзы (рис. 1).
title: Small-scale irrigation potential in Sub-Saharan Africa
title: Targeting investments in technologies, locations and institutions
titleType: AlternativeTitle
Creators: name: Koo, Jawoo
name: Olayide, Olawale E.
name: Sangaré, Saadatou
Publisher: name: Center for Development Research (ZEF)
Year: 2019
Subjects: subject: Africa
subject: Agricultural production
subject: Investment
subject: Irrigation
subject: ddc:333.7
subject: ddc:630

description: The limited access to water the during dry season or a drought greatly restricts farming opportunities and productivity increases in Sub-Saharan Africa. Irrigation can thus be a promising solution to boost levels of agricultural productivity. However, only about 4% of land in the region is irrigated. This is not necessarily due to physical water scarcity. Rather, the main constraint of irrigation is economic water scarcity, i.e. investments in the management of water resources are not substantial enough to meet water demand and farmers do not have the financial means to exploit water resources on their own. Research has shown that small-scale irrigation systems can help adress this economic water scarcity in Africa.
The globular cluster system of the young elliptical NGC 6702
Creators: name: Georgakakis, Antonis E.
name: Forbes, Duncan
name: Brodie, Jean
Publisher: name: Swinburne
Year: 2024

description: We study the globular cluster (GC) system of the dust-lane elliptical galaxy NGC 6702, using B-, V- and I-band imaging observations carried out at the Keck telescope. This galaxy has a spectroscopic age of ~2Gyr suggesting recent star formation. We find strong evidence for a bimodal GC colour distribution, with the blue peak having a colour similar to that of the Galactic halo GCs. Assuming that the blue GCs are indeed old and metal-poor, we estimate an age of 2-5Gyr and supersolar metallicity for the red GC subpopulation. Despite the large uncertainties, this is in reasonable agreement with the spectroscopic galaxy age. Additionally, we estimate a specific frequency of SN=2.3+/-1.1 for NGC 6702. We predict that passive evolution of NGC 6702 will further increase its specific frequency to SN~2.7 within 10Gyr, in closer agreement to that of typical present-day ellipticals. We also discuss evidence that the merger/accretion event that took place a few Gyr ago involved a high gas fraction.
A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites
Creators: name: Arce, Esteban Rodríguez
name: Sarniguet, Cynthia
name: Moraes, Tania S.
name: Vieites, Marisol
name: A. Isabel Tomaz
name: Medeiros, Andrea
name: Comini, Marcelo A.
name: Varela, Javier
name: Cerecetto, Hugo
name: González, Mercedes
name: Marques, Fernanda
name: M. Helena García
name: Otero, Lucía
name: Gambino, Dinorah
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: As part of our efforts to develop organometallic ruthenium compounds bearing activity on both trypanosomatid parasites and tumor cells, a new Ru(II)-cyclopentadienyl clotrimazole complex, [RuCp(PPh3)2(CTZ)](CF3SO3) where Cp = cyclopentadienyl, CTZ = clotrimazole, was synthesized and characterized. The compound was evaluated in vitro on T. cruzi (Y strain), the infective form of T. brucei brucei strain 427 (cell line 449), on three human tumor cell lines with different sensitivity to cisplatin (A2780, ovary; MCF7, breast; HeLa, cervix) and on J774 murine macrophages as mammalian cell model. The new compound is more cytotoxic on T. cruzi and on the tumor cell lines than the reference drugs (Nifurtimox and cisplatin, respectively). In addition, complexation of the bioactive CTZ to the {RuCp(PPh3)} leads to significant increase of the antiparasitic and antitumoral activity. To get insight into the potential “dual” mechanism of antiparasitic action emerging from the presence of Ru(II) and CTZ in a single molecule, the inhibitory effect of this new complex on the biosynthesis of T. cruzi sterols of membrane and the interaction with DNA were studied. Although the tested complex does not affect DNA, it affects the T. cruzi biosynthetic pathway of conversion of squalene to squalene oxide. According to the results here reported, [RuCp(PPh3)2(CTZ)][CF3SO3] could be considered a prospective antiparasitic and/or antitumoral agent that deserves further evaluation.