cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of Biochemical and mutational analyses of a Trametes pyranose oxidase and comparison of its mutants in breadmaking
Creators: name: Li, Mengzhu
name: Deng, Hong
name: Ma, Rui
name: Luo, Huiying
name: Yao, Bin
name: Su, Xiaoyun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1. Amino acid sequence alignment of TsPox with selected pyranose oxidases and primers used in this study.
Additional file 6: of Assessment of performance of the Gail model for predicting breast cancer risk: a systematic review and meta-analysis with trial sequential analysis
Creators: name: Wang, Xin
name: Huang, Yubei
name: Li, Lian
name: Dai, Hongji
name: Song, Fengju
name: Chen, Kexin
Publisher: name: figshare
Year: 2018
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Shows forest plot (A), sensitivity analysis (B) and cumulative analysis ranked by publication year (C) and sample size (D) of calibration of the Gail model after excluding studies conducted in Asian women. (PDF 1202 kb)
Additional file 10: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S5. Weighted Gene Co-expression Network plot of blue module. Red color means hub gene and the thickness of the line represents the connect strength of the interaction. Circle size: the number of connectivity. (PDF 607Â kb)
Additional file 11: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Figure S6. Boxplot of mean methylation of EC1 and EC2â 3. (PDF 155Â kb)
#1 Supporting Information for Mussmann et al.: Cover letter as PDF _____________________________ #2 Supporting Information for Mussmann et al.: "Genetic Rescue, the Greater Prairie Chicken, and the Problem of Conservation-Reliance in the Anthropocene" Parts of this SI (as PDF): A. Thirty six-year history of Greater Prairie Chicken translocations in Illinois B. Details of methodology and results C. References for supporting information - Figures S1-S2 - Tables S1-S4
Creators: name: S. M. Mussmann
name: M. R. Douglas
name: W. J. B. Anthonysamy
name: M. A. Davis
name: S. A. Simpson
name: W. Louis
name: M. E. Douglas
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: A central question in conservation is how best to manage biodiversity, despite human domination of global processes (=Anthropocene). Common responses (i.e. translocations, genetic rescue) forestall potential extirpations, yet have an uncertain duration. A textbook example is greater prairie chicken (GRPC: Tympanuchus cupido pinnatus), where translocations (1992–1998) seemingly rescued genetically depauperate Illinois populations. We re-evaluated this situation after two decades by genotyping 21 microsatellite loci from 1831 shed feathers across six leks in two counties over 4 years (2010–13) and found only 88 unique male genotypes. Low migration rates (less than 1%) established each county as demographically independent, but with declining-population estimates (4 year average N = 79). Leks were genetically similar and significantly bottlenecked, with low effective population sizes (average Ne = 13.1; 4 year Ne/N = 0.166). Twelve significantly different family groups, with r = 0.31 > half-sib r = 0.25, defined genetic structure. Average heterozygosity, indicating short-term survival, did not differ among contemporary, pre- and post-translocated populations, whereas allelic diversity did. Our results, the natural history of GRPC (i.e. few leks, male dominance hierarchies) and its controlled immigration suggest demographic expansion rather than genetic rescue. Legal protection under the endangered species act (ESA) may enhance recovery, but could exacerbate political–economic concerns on how best to manage ‘conservation-reliant’ species, for which GRPC is now an exemplar.
Osteoarthritis severely decreases the elasticity and hardness of knee joint cartilage: A nanoindentation study
Creators: name: Mieloch, Adam Aron
name: Richter, Magdalena
name: Trzeciak, Tomasz
name: Giersig, Michael
name: Rybka, Jakub Dalibor
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: articular cartilage
subject: osteoarthritis
subject: elastic modulus
subject: mechanical properties
subject: nanoindentation
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: The nanoindentation method was applied to determine the elastic modulus and hardness of knee articular cartilage. Cartilage samples from both high weight bearing (HWB) and low weight bearing (LWB) femoral condyles were collected from patients diagnosed with osteoarthritis (OA). The mean elastic modulus of HWB cartilage was 4.46 ± 4.44 MPa in comparison to that of the LWB region (9.81 ± 8.88 MPa, p < 0.001). Similarly, the hardness was significantly lower in HWB tissue (0.317 ± 0.397 MPa) than in LWB cartilage (0.455 ± 0.434 MPa, p < 0.001). When adjusted to patients’ ages, the mean elastic modulus and hardness were both significantly lower in the age group over 70 years (p < 0.001). A statistically significant difference in mechanical parameters was also found in grade 3 and 4 OA. This study provides an insight into the nanomechanical properties of the knee articular cartilage and provides a starting point for personalized cartilage grafts that are compatible with the mechanical properties of the native tissue.
An Expanded Case Study on the Evolution of the Instant Credit Technologies in the Health Sector of Lagos State, Nigeria
Creators: name: Adesoye, Adebanjo
Publisher: name: figshare
Year: 2022
Subjects: subject: Economics
subject: 150307 Innovation and Technology Management
subject: FOS: Economics and business
subject: 150203 Financial Institutions (incl. Banking)
subject: 150202 Financial Econometrics

description: Universal healthcare has become a top priority globally, with international organizations like World Health Organization, United Nations International Children’s Emergency Fund and similar organizations recognizing the importance of health to all. The cost of healthcare does not come cheap and often times comes with a price when needed. The opportunity cost therein compared to saving lives can never be quantified; no wonder World Bank estimated about half of the world’s population in 2017 having the inability to access proper health services. A lot of funding is required for any government to provide quality healthcare services for its citizens. These healthcare finances go a long way in providing for personnel trainings, purchase and maintenance of medical equipment and ensuring further health-related research is sustained. The Nigerian Health sector have functioned overtime to not only be a provider of public health services, but also a point of contact for private individuals to roll out the Health Maintenance Organizations (HMOs) with full permission. In Nigeria, HMOs are the purchasers of health insurance with a social National Health Insurance Scheme (NHIS) for the masses. However, the synchronization between HMOs and the health centers is not solid and thus remains loose. This is largely due to the disconnect amongst the medical centers, HMOs and patients. Due to the challenges involved in the continuous overdependence on the government for extreme health financing, NHIS was signed into law. This was a major achievement under the administration of the first democratic president of Nigeria, Chief Olusegun Obasanjo in 1999. The National Health Insurance Scheme was under the subdivision of the health sector that was responsible for the provision of social health insurance to Nigerians. The possibility of achieving this was because its participants were mostly government staff and they were able to deduct funds from their salary at source, thereby creating a common pool of funds for the health care services rendered. As a developing nation, access to medical facilities is hindered mainly due to constraint in cash that is, funding. The main reason why Nigeria keeps budgeting thousands of dollars every year to this sector cannot be undermined. Solving for this constraint will go a long way in closing the gap amongst these players of the ecosystem – Patients, Medical centers and Insurance premium companies. This study determined their roles and identified how innovation has helped strengthened their functions to coexist.
#frontiers17 Presentation
Creators: name: Psaltis, Athanasios
Publisher: name: figshare
Year: 2017
Subjects: subject: 20202 Nuclear Physics
subject: FOS: Physical sciences
subject: Astrophysics

description: Presentation for the 2017 JINA-CEE Frontiers in Nuclear Astrophysics meeting in Lansing,MI (02.08.2017)
Additional file 7: of Assessment of performance of the Gail model for predicting breast cancer risk: a systematic review and meta-analysis with trial sequential analysis
Creators: name: Wang, Xin
name: Huang, Yubei
name: Li, Lian
name: Dai, Hongji
name: Song, Fengju
name: Chen, Kexin
Publisher: name: figshare
Year: 2018
Subjects: Biological Sciences not elsewhere classified
Science Policy

description: Shows pooled E/O ratio for Gail model 1 and Caucasian-American Gail model 2 after excluding studies conducted in Asian women. (PDF 582 kb)
Additional file 12: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Supplementary material and methods. (DOCX 19Â kb)
Additional file 8: of Assessment of performance of the Gail model for predicting breast cancer risk: a systematic review and meta-analysis with trial sequential analysis
Creators: name: Wang, Xin
name: Huang, Yubei
name: Li, Lian
name: Dai, Hongji
name: Song, Fengju
name: Chen, Kexin
Publisher: name: figshare
Year: 2018
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Shows subgroup analysis of calibration of the Gail model after excluding studies conducted in Asian women. (PDF 106 kb)
Instant Credit in Health_Expanded_Adebanjo Adesoye.docx
Creators: name: Adesoye, Adebanjo
Publisher: name: figshare
Year: 2022
Subjects: subject: Economics
subject: 150307 Innovation and Technology Management
subject: FOS: Economics and business
subject: 150203 Financial Institutions (incl. Banking)
subject: 150202 Financial Econometrics

description: Universal healthcare has become a top priority globally, with international organizations like World Health Organization, United Nations International Children’s Emergency Fund and similar organizations recognizing the importance of health to all. The cost of healthcare does not come cheap and often times comes with a price when needed. The opportunity cost therein compared to saving lives can never be quantified; no wonder World Bank estimated about half of the world’s population in 2017 having the inability to access proper health services. A lot of funding is required for any government to provide quality healthcare services for its citizens. These healthcare finances go a long way in providing for personnel trainings, purchase and maintenance of medical equipment and ensuring further health-related research is sustained. The Nigerian Health sector have functioned overtime to not only be a provider of public health services, but also a point of contact for private individuals to roll out the Health Maintenance Organizations (HMOs) with full permission. In Nigeria, HMOs are the purchasers of health insurance with a social National Health Insurance Scheme (NHIS) for the masses. However, the synchronization between HMOs and the health centers is not solid and thus remains loose. This is largely due to the disconnect amongst the medical centers, HMOs and patients.

 Due to the challenges involved in the continuous overdependence on the government for extreme health financing, NHIS was signed into law. This was a major achievement under the administration of the first democratic president of Nigeria, Chief Olusegun Obasanjo in 1999. The National Health Insurance Scheme was under the subdivision of the health sector that was responsible for the provision of social health insurance to Nigerians. The possibility of achieving this was because its participants were mostly government staff and they were able to deduct funds from their salary at source, thereby creating a common pool of funds for the health care services rendered.

 As a developing nation, access to medical facilities is hindered mainly due to constraint in cash that is, funding. The main reason why Nigeria keeps budgeting thousands of dollars every year to this sector cannot be undermined. Solving for this constraint will go a long way in closing the gap amongst these players of the ecosystem – Patients, Medical centers and Insurance premium companies. This study determined their roles and identified how innovation has helped strengthened their functions to coexist.
Early Impacts of COVID-19 on Household Incomes and Food Consumption – The Kenyan Case
Creators: name: Olwande, John
name: Njagi, Timothy
name: Ayieko, Miltone
name: Maredia, Mywish K.
name: Tschirley, David
name: Olwande, John
name: Njagi, Timothy
name: Ayieko, Miltone
name: Maredia, Mywish K.
name: Tschirley, David
Publisher: name: Unknown
Year: 2021
Subjects: subject: Consumer/Household Economics
subject: Health Economics and Policy
subject: COVID-19
subject: household income
subject: food consumption
subject: kenya

description: Key Facts • Rural and urban areas experienced similar, significant declines in reported incomes of households following the onset of the COVID-19 pandemic. • Majority of households in both areas also experienced reduction in the amount of food they consumed and in the quality of their diet. • There is need to expand social safety net programs to support affected households in both rural and urban areas. • It is important to prioritize mass vaccination.
Additional file 1: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Figure S1. Using R package “ConsensusClusterPlus” to cluster GEO data and the cumulative distribution function (CDF) reaches a maximum when k = 3, thus consensus and cluster confidence is at a maximum. (PDF 1485 kb)
title: 01_1599
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Supplementary information for “Route choice in pedestrians: determinants for initial choices and revising decisions”
Creators: name: Weichen Liao
name: Wagoum, Armel U. Kemloh
name: Bode, Nikolai W. F.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Here we present supplementary information for the article “Route choice in pedestrians: determinants for initial choices and revising decisions” published in Journal of the Royal Society Interface.
Additional file 9: of Assessment of performance of the Gail model for predicting breast cancer risk: a systematic review and meta-analysis with trial sequential analysis
Creators: name: Wang, Xin
name: Huang, Yubei
name: Li, Lian
name: Dai, Hongji
name: Song, Fengju
name: Chen, Kexin
Publisher: name: figshare
Year: 2018
Subjects: Biological Sciences not elsewhere classified
Science Policy

description: Shows sensitivity analysis (A), cumulative meta-analysis ranked by publication year (B) and sample size (C) of discrimination of the Gail model. (PDF 1321 kb)
Electronic supplementary material (Supplementary figures and Tables) from Parallel evolution of mound-building and grass-feeding in Australian nasute termites
Creators: name: Daej A. Arab
name: Namyatova, Anna
name: Evans, Theodore A.
name: Cameron, Stephen L.
name: Yeates, David K.
name: Ho, Simon Y. W.
name: Lo, Nathan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Termite mounds built by representatives of the family Termitidae are among the most spectacular constructions in the animal kingdom, reaching 6–8 m in height and housing millions of individuals. Although functional aspects of these structures are well studied, their evolutionary origins remain poorly understood. Australian representatives of the termitid subfamily Nasutitermitinae display a wide variety of nesting habits, making them an ideal group for investigating the evolution of mound building. Because they feed on a variety of substrates, they also provide an opportunity to illuminate the evolution of termite diets. Here, we investigate the evolution of termitid mound building and diet, through a comprehensive molecular phylogenetic analysis of Australian Nasutitermitinae. Molecular dating analysis indicates that the subfamily has colonized Australia on three occasions over the last approximately 20 Myr. Ancestral-state reconstruction showed that mound building arose on multiple occasions and from diverse ancestral nesting habits, including arboreal and wood or soil nesting. Grass feeding appears to have evolved from wood feeding via ancestors that fed on both wood and leaf litter. Our results underscore the adaptability of termites to ancient environmental change, and provide novel examples of parallel evolution of extended phenotypes.
Supplementary Information from Surface microtopography modulates sealing zone development in osteoclasts cultured on bone
Creators: name: Shemesh, Michal
name: Addadi, Lia
name: Geiger, Benjamin
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Supplementary Information for the article: “Surface Microtopography Modulates Sealing Zone development in Osteoclasts Cultured on Bone” for publication in the Journal of the Royal Society Interface
Symplectic exponential Runge-Kutta methods for solving large nonlinear Hamiltonian systems
Creators: name: Peters, Till
Publisher: name: GAMM Archive for Students
Year: 2024

description: We study exponential Runge-Kutta methods for solving large dimensional stiff Hamiltonian systems. Due to the Hamiltonian structure we would like to preserve this property of the system. So we seek for a way to approximate the matrix exponential terms via Krylov subspace techniques.
description: GAMM Archive for Students, Vol. 6 No. 1 (2024): GAMMAS-The Sixth Year
Comments on scatterometry and optical modelling, and supplementary figures. from Functional optics of glossy buttercup flowers
Creators: name: Kooi, Casper J. Van Der
name: J. Theo M. Elzenga
name: Dijksterhuis, Jan
name: Doekele G. Stavenga
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Buttercup (Ranunculus spp.) flowers are exceptional because they feature a distinct gloss (mirror-like reflection) in addition to their matte yellow coloration. We investigated the optical properties of yellow petals of several Ranunculus and related species using (micro)spectrophotometry and anatomical methods. The contribution of different petal structures to the overall visual signal was quantified using a recently developed optical model. We show that the coloration of glossy buttercup flowers is due to a rare combination of structural and pigmentary coloration. A very flat, pigment-filled upper epidermis acts as a thin film reflector yielding the gloss, and additionally serves as a filter for light backscattered by the strongly scattering starch and mesophyll layers, which yields the matte yellow colour. We discuss the evolution of the gloss and its likely two functions: it provides a strong visual signal to insect pollinators and increases the reflection of sunlight to the reproductive organs, so to heat the reproductive organs.
Supplementary file (Lognormal extension of the manuscript)
Creators: name: Khademi, Navid
Publisher: name: figshare
Year: 2022
Subjects: subject: 150703 Road Transportation and Freight Services
subject: FOS: Economics and business

description: Supplementary file for the following manuscript: Khademi, Navid and Kharrazi, Hamed and Zerguini, Seghir and Chen, Anthony, Departure Time Guidance: A Modeling Framework and Case Study for Commuting Trips with a Fixed Work Start Time. Available at SSRN: https://ssrn.com/abstract=3996132 or http://dx.doi.org/10.2139/ssrn.3996132
Electronic supplementary material (text) from Parallel evolution of mound-building and grass-feeding in Australian nasute termites
Creators: name: Daej A. Arab
name: Namyatova, Anna
name: Evans, Theodore A.
name: Cameron, Stephen L.
name: Yeates, David K.
name: Ho, Simon Y. W.
name: Lo, Nathan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Termite mounds built by representatives of the family Termitidae are among the most spectacular constructions in the animal kingdom, reaching 6–8 m in height and housing millions of individuals. Although functional aspects of these structures are well studied, their evolutionary origins remain poorly understood. Australian representatives of the termitid subfamily Nasutitermitinae display a wide variety of nesting habits, making them an ideal group for investigating the evolution of mound building. Because they feed on a variety of substrates, they also provide an opportunity to illuminate the evolution of termite diets. Here, we investigate the evolution of termitid mound building and diet, through a comprehensive molecular phylogenetic analysis of Australian Nasutitermitinae. Molecular dating analysis indicates that the subfamily has colonized Australia on three occasions over the last approximately 20 Myr. Ancestral-state reconstruction showed that mound building arose on multiple occasions and from diverse ancestral nesting habits, including arboreal and wood or soil nesting. Grass feeding appears to have evolved from wood feeding via ancestors that fed on both wood and leaf litter. Our results underscore the adaptability of termites to ancient environmental change, and provide novel examples of parallel evolution of extended phenotypes.
Supplementary Material for: Dysregulation of the Expression of Asparagine-Linked Glycosylation 13 Short Isoform 2 Affects Nephrin Function by Altering Its N-Linked Glycosylation
Creators: name: Esposito, T.
name: De Stefano, G.
name: Reccia, M.G.
name: Di Lorenzo, I.
name: Napolitano, F.
name: Scalabrì, F.
name: Lombardi, A.
name: Saleem, M.A.
name: Griffiths, L.R.
name: Gianfrancesco, F.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: N-linked glycosylation, which is a post-translational modification process, plays an important role in protein folding, intracellular trafficking and membrane targeting, as well as in regulating the protein function. Recently, we identified a missense variant (p.T141L) in the short isoform 2 of the X-linked gene asparagine-linked glycosylation 13 (ALG13-is2), which segregated with focal segmental glomerulosclerosis and PCCD in a large Australian pedigree; however, any evidence of its pathogenicity was demonstrated. ALG13 gene encodes, through alternative splicing, 2 glycosyltransferase isoforms, which catalyse the second sugar addition of the highly conserved oligosaccharide precursor in the endoplasmic reticulum (ER). Mutations in the long isoform 1 were associated with epilepsy. Methods and Results: Here, we show a different expression of the 2 isoforms depending on the tissue. Specifically, the long isoform is highly expressed in lungs, ovaries, testes, cerebellum, cortex, retina, pituitary gland, and olfactory bulbs, while the short isoform is highly expressed in mouse podocytes and in human podocyte cell lines, at both mRNA and protein levels. The silencing of ALG13-is2 by specific siRNAs induces an altered N-linked glycosylation pattern of nephrin, as demonstrated by the presence of an additional immunostaining band of about 130 kD. In knock-down cells, immunofluorescence analysis shows perturbed organization of the cytoskeleton and altered localization of nephrin on the cellular membrane. We also demonstrated that the altered pattern of N-linked glycosylation induces an over-expression of binding immunoglobulin protein and calreticulin, suggesting ER stress. Conclusions: These results provide preliminary evidence that ALG13-is2 could be an important modifier of renal filtration defects.
Additional file 7: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Figure S2. Seven major modules of gene interaction network in EC1. (PDF 7Â kb)
MOESM1 of RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells
Creators: name: Inana, George
name: Murat, Christopher
name: An, Weijun
name: Yao, Xiang
name: Harris, Ian
name: Cao, Jing
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. Immunofluorescence of human RPE culture. Human RPE cells were obtained from human donor eyes and cultured as described in “Methods”. The RPE culture in 24-well plate was stained with the Pan-Keratin (C11) monoclonal antibody, the Alexa Green-conjugated secondary antibody, and examined by fluorescence microscopy as described in “Methods”. (A) RPE cells stained with the Pan-Keratin antibody, (B) RPE cells stained only with the secondary antibody. The left panel shows the immunofluorescence, and the right shows the phase images. The RPE culture is positive for Pan-Keratin, including CK8 and CK18, confirming it as RPE (47). The staining with the secondary antibody only is negative. Scale bar = 10 µm.
Psicoterapia Sistémica de la Persona. La atención integral del paciente en Psicosomatología
Creators: name: Del Pino Montesinos, José Ignacio
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2024

description: Psicosomàtica y Psiquiatría, Núm. 28 (2024): enero-febrero-marzo
Additional file 8: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: Virology

description: Figure S3. Clustering dendrograms of genes, with dissimilarity based on topological overlap, together with assigned module colors. (PDF 30Â kb)
ACADEMIC ADVISING'S HIDDEN ROLE IN FOSTERING VALIDATION/BELONGING, LEADING TO IMPROVED GRADES
Creators: name: DeRosa, Erin Lion
Publisher: name: Zenodo
Year: 2022
Subjects: advising
belonging
validation
student success
outcomes

description: Recognizing the increasing role that academic advising has come to play in student success strategies, this quantitative study sought to explore the relationships between advising, validation/belonging, and students’ college GPA. The researcher also examined how students’ marginalized status and academic discipline played a role in these relationships. A national sample of 7,211 graduating senior students was used to test a path model. Multiple regression analyses revealed that while there was no direct relationship between advising and GPA, advising had an indirect impact on GPA via students’ experiences of validation/belonging. This was the case for all students, as well as specifically for students from historically minoritized racial groups. First-generation college students were more likely to be satisfied with their advising experiences but had lower validation and belonging, and lower GPAs compared with their peers. Students in STEM majors were less likely to experience validation and were more likely to have lower GPAs than their non-STEM peers. Moving forward, student success strategies, particularly those aimed at closing the equity gap between historically marginalized student communities and their peers, should situate validating practices that foster belonging, self-efficacy, and a sense of self-worth at the center of advising interventions.
Supplementary Material for: The Impact of Depression on the Development of Mild Cognitive Impairment over 3 Years of Follow-Up: A Population-Based Study
Creators: name: Lara, E.
name: Koyanagi, A.
name: Domènech-Abella, J.
name: Miret, M.
name: Ayuso-Mateos, J.L.
name: Haro, J.M.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aims: In the absence of effective treatments for dementia, major efforts are being directed towards identifying the risk factors of the prodromal phase of the disease. We report the incidence rates of mild cognitive impairment (MCI) in a Spanish population sample and assess the effect of depression at baseline on incident MCI (or MCI subtypes) at a 3-year follow-up. Methods: A total of 1,642 participants (age ≥50 years) were examined as part of a Spanish nationally representative longitudinal study. MCI was defined as the presence of cognitive concerns, objective evidence of impairment in one or more cognitive domains, preservation of independence in functional abilities, and no dementia. Depression was assessed through an adaptation of the Composite International Diagnostic Interview (CIDI 3.0). Binary and multinomial logistic regression analyses were carried out to assess the associations. Results: The overall MCI incidence rate was 33.19 (95% CI = 26.02, 43.04) per 1,000 person-years. Depression at baseline predicted the onset of MCI at follow-up after controlling for sociodemographics, cognitive functioning, and other physical health conditions (OR = 2.79; 95% CI = 1.70, 4.59). The effect of baseline depression on incident MCI subtypes was as follows: amnestic MCI, OR = 3.81 (95% CI = 1.96, 7.43); nonamnestic MCI, OR = 2.03 (95% CI = 0.98, 4.21). Conclusion: Depression significantly increases the risk for MCI. Targeting depression among those at risk for dementia may help delay or even prevent the onset of dementia.
Effects of Hesel-coil deep transcranial magnetic stimulation for depression – a systematic review
Creators: name: Nordenskjöld, Axel
name: Mårtensson, Björn
name: Pettersson, Agneta
name: Heintz, Emelie
name: Landén, Mikael
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: One third of the depressed patients are not improved by antidepressant drugs and psychological treatments, and there is a need for additional treatments. Repetitive transcranial magnetic stimulation (rTMS) is being developed towards an alternative in treatment-resistant depression. Deep transcranial stimulation (dTMS) with the Hesel-coil (H-coil) is a further development of rTMS aiming to enhance the effect by getting the magnetic pulses to penetrate deeper into the brain. Aims: This report aims to assess the evidence-base for dTMS for depression. The report also includes an assessment of the ethical and economic aspects involved. Methods: A systematic review of the effects of H-coil dTMS on depression was conducted and the scientific support was evaluated using GRADE (Grading of Recommendations Assessment, Development and Evaluation). Results: Only one controlled study was identified. In the sham-controlled randomized study, 212 participants with major depression that had not responded to antidepressant medication were enrolled. A two-point superiority in Hamilton Depression Rating Scale was observed in the dTMS arm vs the sham-arm at 4 weeks, but the difference was not statistically significant. No serious adverse events were reported apart from rare cases of epileptic seizures. Conclusions: The existing scientific support for H-coil dTMS therapy for depression is insufficient. The clinical implication is that the use of dTMS in depression should be restricted to the framework of clinical trials pending further studies. Fortunately, additional studies are underway and the evidence base should presumably improve over the next several years.
Additional file 9: of Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma
Creators: name: Wu, Peng
name: Liu, Jia-Li
name: Pei, Shi-Mei
name: Wu, Chang-Peng
name: Yang, Kai
name: Wang, Shu-Peng
name: Wu, Song
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Medicine
Cell Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology
Virology

description: Figure S4. Coefficient between modules and clinical parameters. Pvalue is below coefficient value. (PDF 35Â kb)
Editorial: Raising awareness around trends in noncommunicable diseases and their risk factors to promote global prevention and control
Creators: name: Goel, Sonu
name: Verma, Madhur
name: Mohapatra, Archisman
name: Popovic, Stevo
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Non-communicable diseases (NCDs), encompassing cardiovascular diseases, cancer, diabetes, and chronic respiratory illnesses, have emerged as a significant global health challenge, exerting immense pressure on healthcare systems and economies worldwide. As per the World Health Organization (WHO), Non-communicable diseases (NCDs) globally account for 41 million deaths annually, resulting in 74% of global mortality (1). The NCD's contributions to the Disability-adjusted life years (DALY) are the highest globally and is the only disease group for which DALYs increased from 1.47 billion in 2010 to 1.73 billion years in 2021 (2). The multifaceted etiology of NCDs underscores the imperative for comprehensive approaches addressing underlying risk factors and quantifying their impact of exposure to key risk factors is necessary to inform public health policy and practice and help prioritize the use of scarce resources to reduce the existing disparities (3). According to WHO, NCDs arise from a combination of behavioral, metabolic, and environmental risk factors. Modifiable behaviors such as tobacco use, physical inactivity, unhealthy diets, and harmful alcohol consumption significantly elevate NCD risks (1). Metabolic risk factors, including high blood pressure, obesity, elevated blood glucose, and high blood lipids, drive NCD development. Environmental factors like air pollution further exacerbate NCD risks, causing 6.7 million deaths globally, with 5.7 million linked to conditions such as stroke, heart disease, chronic obstructive pulmonary disease, and lung cancer (1). While most of the risk factors are considered modifiable, efforts to minimize them are abysmally low worldwide. One crucial bottleneck to this sluggish response is a lack of awareness or insufficient knowledge about NCDs and their risk factors among people and policymakers.
Domestic or Imported: An Analysis of Rice Demand in Senegal
Creators: name: Faye, Ndèye Fatou
name: Faye, Amy
name: Sy, Mouhammed Rassoul
name: Lee, Seungmin
name: McPeak, John
name: Faye, Ndèye Fatou
name: Faye, Amy
name: Sy, Mouhammed Rassoul
name: Lee, Seungmin
name: McPeak, John
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agricultural and Food Policy
subject: Consumer/Household Economics
subject: Senegal
subject: rice
subject: imports

description: • In Senegal, rural households consume less rice than urban households, but demand for rice is increasing for both types of households (rice consumption as a proportion of cereals has gone up from 24% in 1990 to 40% in 2018). • Urban households spend more on unbroken grain rice while rural households spend more on broken rice. • Urban households consume relatively more unbroken grain local rice while rural households consume more broken imported rice. • To substitute imports, production and availability of locally grown broken rice needs to increase for both rural and urban households. For rural households, better availability of good quality local rice also needs to be ensured. • Rice demand is price inelastic, so subsidies and taxes would have little effect on consumption.
title: The Causes and Consequences of School Closures in Inner-City Calgary
Creators: name: Sandalack, Beverly A.
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: Schools, School closures, Neighbourhood types, Urban adaptation and evolution.

description: During the early decades of the 2000s, eleven schools closed in Calgary’s established neighbourhoods, due to declining enrolment or outdated infrastructure. The loss of a school is often devastating to a community and can lead to further population decline. A research project was commissioned by the government to investigate the causes and consequences of school closures and to make recommendations, particularly related to urban form, to address the issues. Analysis of the 500 sq km study area included historic evolution of urban form, schools mapping and data analysis, development of a typology of school buildings and grounds, mapping of school inter-relationships and closures, review of school board practices and policies, and precedent studies. A case study of the catchment area of one high school included historic evolution of urban form factors, mapping of the network of feeder schools, analysis of neighbourhood and schools socio-demographics, and a review of school program changes. The causes of school closures relate to a combination of city development processes, neighbourhood lifecycles, neighbourhood types, infill and densification processes, housing types, school sizes and building types, socio-demographic factors influencing school choice, and school board policies, and the consequences affect neighbourhoods and communities.
Geomorphology of the Mount Akdag landslide, Western Taurus range (SW Turkey)
Creators: name: Görüm, Tolga
name: Bayrakdar, Cihan
name: Ugur Avdan
name: Çömert, Resul
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This paper presents the results of a geomorphological investigation of Mount Akdag landslide complex, located on the Western Taurus range, SW Turkey. The landslide, resulting in the collapse of a 5 km segment of Mount Akdag, covers an area of 9.8 km2 and has a volume of about 3 × 108 m3. The 1:15,000 scale geomorphological map (Main Map) of the Akdag landslide presented here was produced from a combination of field studies and unmanned aerial vehicle-based DSM, including aerial-photo interpretation and geomorphometric analysis of landforms. The map shows contemporary and past geomorphological hillslope processes and landforms associated with the landslide complex. Our new map suggests that the Akdag landslide was a complex rockslide consisting of multiple landslide types that developed through various movements. We found that 43 highly developed and active mass movements on the main body and side slopes of the landslide made a major contribution to the sediment input. The sediment produced in the upstream severely threatens the touristic site of Saklikent Canyon in the lower catchment via an increasing magnitude of torrents. This map will provide important data for local and national administrators regarding monitoring up-to-date mass-wasting processes, understanding the landslide and its related sedimentary dynamics, and implementing risk assessment and necessary precautions.
title: ÐÐ¿ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¸ ÑÐ¾ÑÐ¾Ð¿ÑÐ¸ÐµÐ¼Ð½ÑÐµ ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð° Ð´Ð»Ñ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½Ð½Ð¾Ð¹ Ð¾Ð¿ÑÐ¸ÐºÐ¸
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ°Ð²ÑÐ´Ð¾Ð², ÐÐ°Ð´Ð¸Ð¼
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2024
Subjects: ÐÐ¾Ð»Ð¾ÐºÐ¾Ð½Ð½Ð°Ñ Ð¾Ð¿ÑÐ¸ÐºÐ°

description: ÐÐ°Ð½Ð½Ð¾Ðµ ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¾ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² Ð²ÑÐ·Ð¾Ð², Ð¾Ð±ÑÑÐ°ÑÑÐ¸ÑÑÑ Ð¿Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð°Ð¼ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ¾Ð² Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 11.03.02 Â«ÐÐ½ÑÐ¾ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ²ÑÐ·Ð¸Â», 11.03.01 Â«Ð Ð°Ð´Ð¸Ð¾ÑÐµÑÐ½Ð¸ÐºÐ°Â» Ð¸ 12.03.03 Â«Ð¤Ð¾ÑÐ¾Ð½Ð¸ÐºÐ° Ð¸ Ð¾Ð¿ÑÐ¾Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸ÐºÐ°Â». Ð ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ð¸ Ñ Ð¤ÐÐÐ¡ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 11.03.02 Ð¸ 12.03.03 Ð´Ð¾Ð»Ð¶Ð½Ñ Ð¸Ð¼ÐµÑÑ Ð·Ð½Ð°Ð½Ð¸Ñ Ð¸ Ð½Ð°Ð²ÑÐºÐ¸ (ÐºÐ¾Ð¼Ð¿ÐµÑÐµÐ½ÑÐ¸Ð¸) Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¾Ð¿ÑÐ¸ÐºÐ¸, ÑÐ¾ÑÐ¾Ð½Ð¸ÐºÐ¸ Ð¸ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð¸ÐºÐ¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð¾Ð»Ð¶Ð½Ñ ÑÐ¼ÐµÑÑ Ð²ÑÐ±Ð¸ÑÐ°ÑÑ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÑ Ð¸ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ð´Ð»Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÑÐ¾ÑÐ¾Ð¿ÑÐ¸ÐµÐ¼Ð½ÑÑ ÑÑÑÑÐ¾Ð¹ÑÑÐ², ÑÐµÑÐ°ÑÑ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸ Ð¿ÑÐ¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¸ ÑÐºÑÐ¿Ð»ÑÐ°ÑÐ°ÑÐ¸Ð¸ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½Ð½Ð¾-Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ¸ÑÑÐµÐ¼ ÑÐ²ÑÐ·Ð¸. Ð Ð¿Ð¾ÑÐ¾Ð±Ð¸Ð¸ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ ÑÐ¸Ð¿Ñ ÑÐ¾ÑÐ¾Ð´Ð¸Ð¾Ð´Ð¾Ð² Ð² Ð¸Ð½ÑÐµÐ³ÑÐ°Ð»ÑÐ½Ð¾Ð¼ Ð¸ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ð¸ Ð¸ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð¾Ð±Ð¸Ð»ÑÐ½ÑÑ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¾Ð², ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ñ Ð´Ð»Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ°Ð±Ð¾Ñ Ð¿Ð¾ ÑÐµÐ¼Ð¾Ð½ÑÑ ÐÐÐÐ¡ Ð¸ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ Ð¸Ð½ÑÐµÐ³ÑÐ°Ð»ÑÐ½ÑÑ ÑÐ¾ÑÐ¾Ð¿ÑÐ¸ÐµÐ¼Ð½ÑÑ ÑÑÑÑÐ¾Ð¹ÑÑÐ², ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÐ°Ð»Ð¸Ð·ÑÑÑÑÑ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐ¸Ð¿Ð¾Ð² ÑÐ¾ÑÐ¾Ð´Ð¸Ð¾Ð´Ð¾Ð² Ð´Ð»Ñ ÑÑÑÑÐ¾Ð¹ÑÑÐ² Ð¸Ð½ÑÐµÐ³ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¾Ð¿ÑÐ¸ÐºÐ¸. ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ ÑÑÐµÐ¼Ñ Ð²ÐºÐ»ÑÑÐµÐ½Ð¸Ñ ÑÐ¾ÑÐ¾Ð¿ÑÐ¸ÐµÐ¼Ð½Ð¸ÐºÐ¾Ð² Ð´Ð»Ñ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð¸Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº. Ð¡ÑÑÐ´ÐµÐ½ÑÑ Ð¿ÐµÑÐµÐ´ Ð¸Ð·ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð´Ð¸ÑÑÐ¸Ð¿Ð»Ð¸Ð½Ñ Ð´Ð¾Ð»Ð¶Ð½Ñ Ð¸Ð¼ÐµÑÑ Ð±Ð°Ð·Ð¾Ð²ÑÐµ Ð·Ð½Ð°Ð½Ð¸Ñ Ð¿Ð¾ Ð´Ð¸ÑÑÐ¸Ð¿Ð»Ð¸Ð½Ð°Ð¼ Â«Ð¤Ð¸Ð·Ð¸ÐºÐ°Â», Â«Ð¢ÐµÐ¾ÑÐ¸Ñ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÐ¿ÐµÐ¹Â», Â«ÐÐ¿ÑÐ¸ÐºÐ°Â», Â«ÐÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸ÐµÂ» Ð¸ Â«ÐÐµÑÑÐ¾Ð»Ð¾Ð³Ð¸Ñ, ÑÑÐ°Ð½Ð´Ð°ÑÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð¸ ÑÐµÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸ÑÂ».