cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel Capsid-Interacting Cellular Factors in HIV Uncoating
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The absence of a vaccine and the limitations of current HIV therapeutic regimens have prompted the investigation into alternate methods to prevent or delay the progression of HIV disease. Because drugs that target the virus invariably lose their potency because HIV develops resistance, targeting cellular proteins required for virus replication is an increasingly attractive avenue for intervention. HIV is an obligate parasite and is dependent on the host cell for virtually every step of the virus life cycle. However, we have a limited working knowledge of the numerous cellular proteins essential for HIV replication. We previously reported on a mutant strain of HIV that had impaired replication capacity but that could overcome this defect when exposed to cells that were activated through an external stimulus. These findings suggested the existence of host cell proteins in activated cells that could rescue the mutant virus, and we pursued this hypothesis to identify six cellular factors that not only rescue the mutant virus but that are also essential for replication of wild-type HIV. Here, we propose experiments aimed at determining more precisely the relationship between the newly identified host factors and HIV replication. More importantly, identification of novel HIV-interacting cellular factors may provide additional targets for much needed, novel therapeutic interventions.
Aquatic ecology of the New Jersey Pinelands
Creators: name: Lloyd, T.
name: Hastings, R. W.
name: White-Reimer, J.
name: Arsenault, J. R.
name: Arsenault, C.
name: Merritt, M.
Publisher: name: No Publisher Supplied
Year: 1980

description: Aquatic life in the streams, lakes and bogs of the Pinelands National Reserve/Pinelands area has been investigated. The study area encompasses more than 2,000 square miles in Central and Southern New Jersey. It supports a relatively unique flora and fauna consisting of species adapted to the acid water and other environmental characteristics.This study, which was performed for the State of New Jersey Pinelands Commission, is one of the inputs to a plan for the region being prepared by the Commission. The principal objectives of the aquatic ecology study were:1) provide an inventory of aquatic life in all of the more important watersheds of the Pinelands area, and describe the composition of characteristic aquatic communities2) identify specific areas which are believed to support "pristine" communities and therefore warrant protection3) identify areas which appear to be degraded and specify, to the extent possible, factors which have deleterious effects on characteristic Pinelands aquatic communities4) recommend various land and water management practices which would help to preserve or protect characteristic aquatic ecosystems.
Musca funebris Fabricius 1787
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Anthomyiidae
Musca
Musca funebris

description: funebris (Fabricius), 1787: 345 (Musca). Type locality: Denmark, Copenhagen [=Hafniae]. ST F (UZMC). Comb. Fallén 1823: 5. Citation of HT in Rocha Pité & Tsacas 1980: 39. PA NE NT AF OR AU Distr.: Worldwide excepts tropics. Colombia (Bogota, D.C). Refs.: Hunter, 1964: 39; Hunter 1966: 416.
clarkii Hutton, 1901: 91. Type locality: New Zealand, Christchurch. T A (LCNZ). Syn. Wheeler et al. 1962: 396.
dudai Maloch, 1934: 444. Type locality: Chile, La Araucania, Angol. HT M (USNM). Syn. Wheeler et al. 1962: 396.
Leucophenga atkinsoni Miller, 1921: 302. Type locality: New Zealand. ST B (BMNH?). Comb. & syn. Harrison, 1959: 298.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 726, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Report to the New Jersey Pinelands Commission on the financial component of the comprehensive management plan and an evaluation of payments in lieu of taxes: Vol II, appendicies
Creators: name: Government Finance Associates, Inc.
Publisher: name: No Publisher Supplied
Year: 1980

description: This document is a collection of the seven appendices to the 1980 report to the New Jersey Pinelands Commission on the financial component of the comprehensive management plan and an evaluation of payments in lieu of taxes.
Final report: Recommendations for on-site wastewater disposal alternatives, future studies and management options; Assessment of innovative and alternative technologies for on-site wastewater disposal; A procedure for evaluating environmental impacts of alternative wastewater treatment technologies; Standards and criteria for the design and maintenance of on-site wastewater treatment systems
Creators: name: DSI Environmental Engieers
Publisher: name: No Publisher Supplied
Year: 1980

description: This is a collection of four reports studying the effects of on-site wastewater disposal and treatment (i.s. septic tanks) and their environmental impacts.
Technical Memos: Pinelands Commission Surface Water Quality
Creators: name: Betz, Converse
Publisher: name: No Publisher Supplied
Year: 1980

description: This report is a collection of seven technical memorandums describing the surface water quality of the New Jersey Pinelands. The water quality of the Pinelands was assessed by reviewing existing monitoring data, the needs of water consumers and the relationship between pollution sources and water quality. General pollution control measures were reviewed and management techniques were recommended. Six technical memorandum were produced which detail the methods, findings and recommendations of this study.In addition to providing a general description of the six technical memorandums, this summary interprets the study findings and presents the consultants' overall view of the critical issues in protecting Pine lands water quality. Management alternatives and recommendations presented in this summary are not found in individiual technical memorandums. Ideas for future study are also provided.
Pristis zijsron Bleeker 1851
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Pristiformes
Pristidae
Pristis
Pristis zijsron

description: Pristis zijsron Bleeker, 1851
Green Sawfish
Pristis zijsron Bleeker, 1851: 442. Holotype: RMNH 7418 (rostrum only). Type locality: Bandjarmasin, Kalimantan, Indonesia.
Local synonymy: Pristis zijaron— Filewood, 1973: 10 (PNG). Pristis zijsron— Kailola, 1987: 24 (Daru; Balimo; Gulf of Papua; Bootless Bay); White et al., 2017a: 277 (PNG); White et al., 2018: 198, figs (PNG).
PNG voucher material: (3 spec.) CAS SU 40592 (rostrum), ~ 1515 mm TL, Sepik River, 1 May 1929; KFRS E.378 (dried rostrum), rostrum length 285 mm, Balimo area, May ̄ Jul. 1968; KFRS E.411 (dried rostrum), rostrum length ~ 880 mm, Bootless Bay, Port Moresby, 8 May 1970.
Remarks: First recorded from PNG by Filewood (1973). Dried fins observed from coastal fisheries during recent surveys in the Gulf and Western Provinces. An additional specimen from the KFRS collection is considered lost or destroyed.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 46, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Final report: Recreational component of the New Jersey Pinelands comprehensive management plan
Creators: name: Committa Fredrick Associates
Publisher: name: No Publisher Supplied
Year: 1980

description: This study is concerned with an evaluation of existing recreational land use and the preparation of a plan for the future recreational use of the New Jersey Pinelands. As such, it addresses what may be regarded as the most appropriate use of this ecologically unique, relatively undeveloped area of southern New Jersey. More precisely, the Pinelands, for the purposes of this study, is defined by the Federally legislated Pinelands National Reserve, which measures 1,082,800 acres. (The study area also includes two small sections of the Critical Area of the Pinelands which lie outside the National Reserve.) The study area Is, therefore, said to measure approximately 1.1 million acres.The principal focus of this study is embodied in the following lIst of recreational activities:hunting (deer, small game); fishing (saltwater, freshwater, shellfishing, crabbing); horsebackridlng; canoeing; camping (motorized and non-motorized; wilderness, family and organized group); picnicking; nature study (birding, botanizing); photography; bicycling; motorcycling; ORVS; hiking; cross-country skiing; driving for pleasure; sightseeing; swimming; and boating.
Bartonella Vomp adhesins and pathogenesis in AIDS patients
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Bartonella quintana is an opportunistic bacterial pathogen that persists for months in the human bloodstream, and causes relapsing fever, heart valve infection, and bacillary angiomatosis. B. quintana infection produces debilitating or fatal illness in immunocompromised individuals with AIDS, transplanted organs, or undergoing treatment for cancer. It also causes serious infections in people with a normal immune system. Although the infection occurs worldwide, more cases of HIV-associated B. quintana infection have been reported in San Francisco and California than in any other location. Little is known about the mechanisms by which Bartonella is able to infect and cause disease in humans. One critical aspect of B. quintana infection is attachment to red blood cells (RBC). This enables the bacterium to infect sites throughout the body and escape detection by the host immune system. We identified a family of four variably-expressed outer membrane proteins (Vomp) that are involved in binding of B. quintana to host cells, including RBC. The predicted structure of the Vomp is similar to proteins from other pathogenic organisms, such as the gonorrhea bacterium, which are critical for infecting humans. Because the structure of these proteins is important for their function, I will study the structure of the Vomp and their role in binding to and infecting RBC, both in test tubes and animals. Because binding to RBC is critical for Bartonella infection, understanding this mechanism will enable us to better prevent and treat Bartonella infections in AIDS patients.
Reptiles and amphibians of the New Jersey Pinelands: A status report describing the distribution and habitat requirements of selected less common herpetofauna of the New Jersey Pine Barrens with issues and recommendations for the protection and maintenance of their sustaining habitats
Creators: name: , Conservation
Publisher: name: No Publisher Supplied
Year: 1980

description: Of the fifty nine herptile species known to inhabit the New Jersey Pinelands, thirty one were selected for intensive study because their occurrence in the Pinelands is relatively unique or because their populations are known to be declining. Snake populations in particular seem to have experienc:ai the sharpest declines because their habitats have fleen destroyed by development or they have been overcollected as trophies or for the illegal pet market.This report finds that the downward population trends of unique, threatened or endangered amphibians and reptiles like the Pine Barrens treefrog, the pine snake, the northern scarlet snake, the timber rattlesnake, the bog turtle and the marbled salamander can be halted or reversed if the Pinelands Management Plan includes a list of eleven measures detailed in the report.
Drosophila fuscolineata Duda 1925
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila fuscolineata

description: fuscolineata Duda, 1925: 213. Type locality: Costa Rica. Catargo, La Suiza de Turrialba. LT M (HNHM). As HT in Wheeler, 1963: 53. Lectotype des. Bachli 1984: 241. NT Distr.: Mexico to Brazil. Colombia (Cundinamarca (Fusagasugá), Valle del Cauca (Palmira)). Refs.: Wheeler, 1957: 99; Hunter & Navarro 1969: 1102; Hoenigsberg 1995a: 87, 1995b: 177.
castanea Patterson & Mainland, 1944: 51. Type locality: Mexico, Veracruz, Sedeno Canyon near Jalapa. T A (USNM). Syn. Vilela & Bachli 1990: 65.
fumosa Pavan & Cunha, 1947: 31. Type locality: Brazil, São Paulo, Iporanga. LT M (MZUSP). Lectotype des. Val 1982: 314. Syn. Vilela & Bächli 1990: 65.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on pages 726-727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Rhinidae Muller & Henle 1841
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinidae

description: Family Rhinidae Müller & Henle, 1841
Wedgefishes
Local synonymy: Rhinobates jaram Montrouzier, 1857: 498 (Woodlark Island). Rhynchobatus djiddensis— Munro, 1958: 113 (Mukawa). Neither of above can be verified to a species but refer to a member of this family.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 47, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
BALIQLAR SINFIGA UMUMIY TAVSIF VA TOG'AYLI BALIQLAR SINFINING TASHQI TUZULISHI
Creators: name: Mirzasultonova, Shaxzoda
Publisher: name: Zenodo
Year: 2024

description: ushbu tezisda umurtqali hayvonlar tipiga kiruvchi baliqlar sinfinning tashqi tuzulishiga umumiy tavsif va tog’ayli baliqlar sinfining tashqi tuzulishi haqida ma’lumotlar berilgan.
Rhina Bloch & Schneider 1801
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Rhina

description: Genus Rhina Bloch & Schneider, 1801
Bowmouth Guitarfish
Rhina Bloch & Schneider, 1801: 352. Type designation by indication under ICZN Opinion 6. On official list; Rhina Schaeffer, 1760, Rhina Walbaum, 1792, and Rhina Rafinesque, 1810a placed on Official Index (Opinion 345). Valid as Rhina Bloch & Schneider, 1801.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 47, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Adolescent Risk Environments: A Situation-Focused Approach
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Unsupervised or ineffectively supervised adolescent parties are settings where adolescents can experiment with a number of risk behaviors. Of these, sexual behavior is of particular concern because of the possibility of HIV transmission. Our own previous research with adolescents, although not focused on parties, indicates that adolescent parties are a venue for sexual experimentation. Adolescent parties are an environment where ordinary decision-making is altered because of the unique sociocultural context and because of the use of intoxicants such as alcohol and marijuana. Alcohol consumption at adolescent parties impairs judgment and increases the likelihood that adolescents will have sexual encounters that one or both partners will later regret. At these parties, males encourage females to drink until they are partially unaware and lack judgment as a strategy for having intercourse. Sexually inexperienced adolescents may seek out sexual encounters with relative strangers at parties because they know that they will not have to deal with the social aftermath at school. According to accounts obtained in earlier studies, condom use during sex is less likely when sex occurs at a party. Adolescent sexual behavior at parties has not been studied largely because this behavior is difficult or impossible to observe. In the proposed research, we experiment with a newly developed Situation-Focused Interview that uses repetition of a topic to increase accuracy in recalling past events. We intend specifically to study 10th grade adolescent parties because other research we have conducted indicates that 10th grade is a period when adolescents are less likely to be in committed relationships and when they are likely to have a greater number of casual sexual partners. The specific aims of the research are 1) to document the social environment of the 10th grade adolescent party and 2) to document participant cognition and decision making in this setting. The study promises to provide information that will be useful in increasing the authenticity of health education messages promoting non-attendance at parties, sexual abstinence, or safe sexual behavior in this setting. The Situation-Focused Interview also promises to be useful in designing health education messages to reduce the risk of HIV infection in other settings where HIV infection is likely to occur.
Threatened and endangered vascular plant species of the New Jersey Pinelands and their habitats
Creators: name: Calazza, Nicholas
name: Fairbrothers, David E.
Publisher: name: No Publisher Supplied
Year: 1980

description: Within this century, several species of plants native to the New Jersey Pinelands have become jeopardized with extinction. In order to bring this issue to light, 71 rare species (including ferns, grasses, sedges and broadleaved plants) have been inventoried and assigned Endangered, Threatened or Undetermined status for the Pinelands in this report. Descriptions of specific habitats, general locations, geographic affinities, flowering times, and listings by habitat type, watershed and county are also given for each Endangered and Threatened species. A study of this information shows that more of the inventoried species are found in wetland habitats than in the drier, upland areas of the Pinelands.
Rhina ancylostoma Bloch & Schneider 1801
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Rhina
Rhina ancylostoma

description: Rhina ancylostoma Bloch & Schneider, 1801
Bowmouth Guitarfish
Rhina ancylostomus Bloch & Schneider, 1801: 352, pl. 72. Lectotype: ZMB (lost), Paralectotype, ZMB 4621 (1, dry, lost). Type locality: Coromandel, India.
Local synonymy: Rhina anclyostoma— Filewood, 1973:10 (PNG); Kailola, 1987: 26 (Sepik River mouth); White et al., 2018: 200, figs (PNG).
PNG voucher material: (1 spec.) KFRS E.476 (dried jaws), no collection data.
Remarks: First recorded from PNG by Filewood (1973), presumably based KFRS E.476; KFRS E.476 not present in elasmobranch cards in the collection; the only KFRS specimen of this species was a dried jaw KFRS E.262 (Sepik River mouth, Jul. 1966) which was listed as found in 2000 but was not found in the current study; possibly previously found without a registration number and allocated a new number unnecessarily, but cannot be confirmed. Recorded from coastal fisheries catches and as bycatch from the Gulf of Papua prawn trawl fisher during recent surveys.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 47, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
A conceptual framework for Pinelands decision-making
Creators: name: Robichaud, Beryl
Publisher: name: No Publisher Supplied
Year: 1980

description: This report stems from a request of the Pinelands Commission staff to enlist a group of scientists to define the essential character of the Pinelands natural environment, to explain how it came to be, to forecast what might cause future change in it, and to identify planning policies and management actions to ensure the continued existence of the essential character of the present Pinelands environment.
Rhynchobatus Muller & Henle 1837
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Rhynchobatus

description: Genus Rhynchobatus Müller & Henle, 1837a
Wedgefishes
Rhynchobatus Müller & Henle, 1837a:116. Type species: Rhinobatus laevis Bloch & Schneider, 1801, by monotypy.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 47, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Diffusion-Weighted MRI in Monitoring Breast Cancer Treatment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Effective chemotherapy can potentially treat micro-metastases as well as the primary tumor, reducing the risk of later metastasis and improving overall survival. Chemotherapy implemented prior to surgery (neoadjuvant chemotherapy) allows for the additional benefits of (1) potential tumor down-staging and the option of breast-conserving surgical methods and (2) the ability to assess the tumor's response to chemotherapy while the tumor is still present. Improved methods of monitoring the tumor’s response to chemotherapy are needed. Towards that end, we are interested in diffusion-weighted magnetic resonance imaging (DW-MRI) as a non-invasive, non-contrast, and non-ionizing method that could predict early treatment response to neoadjuvant chemotherapy. DW-MRI is sensitive to the random motion of water molecules, allowing for the detection of microscopic changes in cell density and cell content.

 This research addresses the questions: (1) Can DW-MRI provide information regarding tumor response that is valuable in predicting immediate and long-term patient outcomes?, (2) Does this information add value to established markers?, and (3) How can DW-MRI analysis be made more automated? These aims will be addressed by: (1) retrospective studies at our breast cancer center in women over age 18 with locally advanced breast cancer and treated with neoadjuvant chemotherapy, (2) multivariate statistical analysis, and (3) image post-processing and computerized algorithms to facilitate the use of DW-MRI in evaluating response to neoadjuvant chemotherapy in the clinical setting.

 The overarching goal of our research is to examine and develop the utility of DW-MRI in predicting treatment response and to work towards improving overall outcomes for patients with breast cancer. Earlier determination of response to neoadjuvant chemotherapy could allow ineffective treatment regimens to be discontinued, sparing patients exposure to side effects. Patients could also be switched to alternative chemotherapy regimens, potentially improving treatment response and overall survival from breast cancer.
An assessment of the impact of septic leach fields, home lawn fertilization, and agricultural activities on groundwater quality
Creators: name: K.W. Brown And Associates
Publisher: name: No Publisher Supplied
Year: 1980

description: The available information on the potential for movement of nutrients, pathogens and organic compounds to the groundwater from septic leach fields, fields irrigated with secondary treated sewage effluent, and fertilized lawns and agricultural fields under the New Jersey Pinelands soils was reviewed and utilized to develop predictions of pollution hazards associated with these practices.
A Candidate Breast Cancer Metastasis Protein
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Src is a tyrosine kinase oncogene and is found to be activated in most breast cancers. We have been studying the functions of src in breast cancers and have cloned a new src target protein, called Trask that is usually phosphorylated during mitosis in normal cells, but is phosphorylated continuously in many breast cancer cells. When we increase the amount of Trask in breast cancer cells, the cells detach and separate, similar to what happens in metastasis. In a survey of normal human tissues, we found that Trask is expressed in most epithelial tissues, including breast epithelium, but is never phosphorylated in any of these normal tissues. In a survey of breast cancer cell lines, we have found that Trask is abnormally phosphorylated in many breast cancer cell lines but not in a normal breast epithelial cell line. This has led us to believe that Trask may be a key mediator of tumor metastasis in breast cancers.

 We believe that the physiologic function of Trask is to allow cells to temporarily detach during cell division. However in breast cancers, this mechanism is prematurely activated by hyperactive src kinases leading to detachment of cancer cells to promote metastasis. In cell culture systems we will explore the molecular mechanism by which we think Trask regulates cell adhesion. ?-catenin was first identified as a structural protein that binds to E-cadherin on the cell membrane to confer cell adhesion. During tumorigenesis, the E-cadherin/?-catenin association is usually lost, leading to the loss of adhesion function. The loss of this complex is mediated by src-phosphorylation of ?-catenin. It is possible that phospho-Trask brings src kinases in proximity to the E-cadherin/?-catenin complex, where src can phosphorylate ?-catenin more readily. In mouse models we will determine whether overexpression and phosphorylation of Trask induces MCF-7 breast cancer cell metastasis. In parallel studies using human tumor samples, we will determine by immunohistochemistry (IHC) whether there is increased Trask phosphorylation in primary tumor and metastasis specimens. We have already developed antibodies to differentiate Trask and its phosphorylated forms.

 If our hypothesis is proven, then Trask will be a unique protein because it is specifically phosphorylated in breast cancers, but not in normal breast cells. If we find that it is phosphorylated specifically in cancer metastasis, it will be the first such protein described. In either case, it is potentially a novel biomarker that may identify which patients could benefit by being treated with src inhibitors. If we show in our mouse models that Trask promotes the development of metastases, than it will identify a whole new pathway for follow-up studies. This may lead to the successful use of new targeted therapies that may have fewer side effects than chemotherapy.
Planning the use and management of the Pinelands: An historical, cultural, and ecological perspective
Creators: name: Berger, Jonathan
Publisher: name: No Publisher Supplied
Year: 1980

description: Field work and the analysis of published and statistical data led to the delineation of a range of cultural sub-regions of the Pinelands. These differ to such a degree that the Commission must be prepared to consider and implement site-specific planning strategies for each subregion. A composite of these regions creates the character of the Pinelands, which is established enough on its own that general policies can be described which pertain to planning in any region. These policies are described in the chapter entitled "General Pinelands Issues". The issues listed in that chapter were repeated time after time in interviews conducted throughout the varied regions of the Pinelands, and have been grouped for convenience into the following general categories: Financial; Distrust of Government; Preservation of a Culture; Land Management; Plan Goals; Plan Flexibility; and Plan Administration.
Forest Vegetation of the Pinelands
Creators: name: Andropogon Associates
Publisher: name: No Publisher Supplied
Year: 1980

description: Pinelands vegetation was mapped on 50 transparent mylar overlays of 1:24,000-scale U.S.G.S. quad sheets. This detailed mapping provides an inventory of current forest types and their distribution, as well as habitat base-maps for coordinating and. recording the 'information of other natural-resource consultants. Comparisons with the previous (1973) vegetation mapping were valuable in discerning trends in the intervening period.
Drosophila gasici Brncic 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila gasici

description: gasici Brncic, 1957b: 92. Type locality: Chile, Taarapacá, Arica, Camarones. LT M (MNHNS). NT Distr.: Argentina, Bolivia, Chile, Colombia (Bogota, D:C, Antioquia, Magdalena, Caldas, Nariño), Ecuador, Venezuela. Refs.: Hunter, 1964: 39; Hunter, 1966: 416; Vilela & Bächli, 2004a: 74.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Rhinobatos Linck 1790
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Rhinobatos

description: Genus Rhinobatos Linck, 1790
Rhinobatos Linck, 1790: 32. Type species Raja Rhinobatos Linnaeus, 1758; type assumed from tautonymy.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 48, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Pinelands Commission New Jersey Hydrogeology Assessment
Creators: name: , Geraghty
Publisher: name: No Publisher Supplied
Year: 1980

description: This report is an assessment of the Pinelands ground-water. Major aquifers, or water-bearing units of the Pinelands are, from oldest to youngest, the Potomac-Raritan Magothy sequence, the Englishtown Formation, the Wenonah Formation and Mt. Laurel Sand, the Kirkwood Formation, and the Cohansey Sand.
Drosophila griseolineata Duda 1927
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila griseolineata

description: griseolineata Duda, 1927: 161. Type locality: Brazil, Rio de Janeiro, Petrópolis. LT M (ZMHU). NT Distr.: Bolivia, Brazil, Colombia (Bogota, D:C, Antioquia (Medellin), Cundinamarca (Fusagasugá)), Ecuador, Venezuela. Refs.: Hunter, 1964: 39; Hunter, 1966: 417; Hunter & Navarro, 1969: 1102; Yoon, 1996: 41.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Sphyrna zygaena
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Sphyrna
Sphyrna zygaena

description: Sphyrna zygaena (Linnaeus, 1758)
Smooth Hammerhead
Squalus zygaena Linnaeus, 1758: 234. Syntype: NRM LP 88 (see Fernholm & Wheeler, 1983). Type locality: Mediterranean Sea and Atlantic (incl. Spain, France, Italy, Greece, Syria).
Local synonymy: Sphyrna zygaena — Filewood, 1973: 2 (may occur in PNG); White et al., 2018: 190, figs (PNG). PNG voucher material: None.
Remarks: Mainly recorded from temperate regions but also found in some tropical regions. Confirmed from coastal fisheries catches in Milne Bay Province; molecular data supports the identification (S. Appleyard, unpubl. data).
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 44, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Technical Memos: Pinelands Commission Surface Water Quantity
Creators: name: Betz, Converse
Publisher: name: No Publisher Supplied
Year: 1980

description: Two of the principal objectives of the entire Pinelands program are to identify and assess the potential impacts of development on the Pinelands natural systems and to develop recommendations to protect these systems. Towards these ends, an investigation into the hydrologic characteristics of Pinelands surface waters was conducted.Water is essential to the support of all elements of the physical and biological components of the Pinelands. The landscape was shaped by moving water, the rorests reQuire it for growth, rish and wildlife need it for habitat and growth and it is essential for all of the activities of man, including agriculture and urban development. Because of the importance of water to the maintenance of the Pinelands ecosystems, and because of the fragility of the water balance observed in developing and developed areas' outside the Pinelands, a considerable effort mas been made to identify and assess the existing hydrologiC relationships in the region. Much of this information. was developed with the knowledge that understanding the existing water relationships was essential in order to determine the potential impacts of development on the Pinelands and to establish sound recommendations for protecting the environment.
Macrophages in Breast Cancer Patients of African Descent
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The normal immune system employs cells called macrophages to function against both infection and various types of inflammation. In response to proteins called cytokines, macrophages produce angiogenic and stromal breakdown factors, both of which are beneficial in certain settings, such as wound healing. However, a large body of research now shows that many cancer cells can attract macrophages, subverting their role to facilitate cancer growth and spread via angiogenesis. In fact, examination of breast cancer specimens from women we have treated has shown that high numbers of macrophages predict poor outcomes. Given reports of particularly aggressive breast cancers in Nigerian women, we became interested in looking for macrophages in breast cancer specimens from Nigeria. Subsequently, we found that many more Nigerian breast cancer patients had high levels of tissue macrophages in their cancers than women in the U.S. This intriguing finding implicates macrophages in the pathogenesis of aggressive breast cancers. Other work from our group suggests that high levels of tissue macrophages portend poor prognosis in breast cancer.

 Since women of African descent in the U.S. have poor outcomes following diagnoses of breast cancer, even when controlling for factors such as access to health care, we are interested in investigating whether or not these women have higher levels of tissue macrophages compared to other groups. Additionally, we hope to correlate tissue macrophage level with a blood marker. There is now a critical mass of data from in vivo and clinical studies showing that macrophages play a role in the progression and possibly in the development of some breast cancer subtypes. Understanding the role macrophages may shed light on outcomes disparities in the U.S., and lead to new detection techniques and prognostic information. Specifically, we will obtain breast tissue samples from African American women and non-African American women with breast cancer and determine the incidence of high levels of pathogenic tissue macrophages. Next, we will obtain serum samples from breast cancer patients and correlate tissue macrophage levels with blood markers.

 This work has the potential to identify an explanation for outcomes disparities in women of African descent in the U.S. Additionally, we hope to identify a blood marker that could be used for detection, prognostic information, and following response to treatment. The ultimate goal would be the identification of patients who could benefit from the use of novel anti-macrophage agents currently in development.
Drosophila hansonioides Pipkin 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila hansonioides

description: hansonioides Pipkin, 1966a: 4. Type locality: Panama, Panama, Cerro Campana, 2500 ft. LT M (USNM). NT Distr.: Colombia (Valle del Cauca (Rio Raposo)). Refs.: Pipkin et al., 1966: 142.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Discovering Compounds Blocking Assembly of LRH-1
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The focus of this project involves a nuclear receptor, called LRH-1 (liver receptor homolog-1) recently found to be present at high levels in breast tumor cells and surrounding adipose tissue. LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroid formation. The link to breast cancer was demonstrated by studies showing that LRH-1 inactivation would block estrogen-dependent proliferation of breast cancer cells. In addition, LRH-1 controls the expression of genes coding for two cell cycle regulatory cyclins that are thought to be important in tumor maintenance. Finally, LRH-1 powerfully enhances expression of aromatase, the only enzyme that converts androgen to estrogen, stimulating tumor progression. Thus, inhibitors of LRH-1 would potentially be the key to shutting off multiple pathways associated with breast cancer progression.

 The goal of this project is to identify small molecules that inhibit the LRH-1 transcriptional activity in breast cancer cells. Our approach is to employ an innovative screen for inhibitors of the LRH-1 transcriptional assembly. First, we will screen chemical libraries for compounds targeting the regulatory binding sites and interaction surfaces of LRH-1 that participate in binding to other essential co-regulators. The technologies used will be Surface Plasmon Resonance (SPR) followed by X-ray crystallography to “map” protein-compounds interaction sites. Finally, we will evaluate the effects of these new LRH-1 antagonists by testing them in breast cancer cells, such as MCF-7, MDAMB-453 and ZR-75-1 cell lines.

 The discovery of LRH-1 specific inhibitors would provide a new route to block aromatase. The critical role of LRH-1 in regulating aromatase transcription in malignant breast, but not in normal breast, bone or brain suggests that these inhibitors should be more selective and could not have the side effects observed for current generation aromatase inhibitors. Furthermore, because the role of LRH-1 in breast cancer merits further study, these compounds could represent powerful tools to validate key molecular mechanisms of LRH-1 in breast cancer development and tumor progression.
Rhinobatos manai White, Last & Naylor 2016
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Rhinobatos
Rhinobatos manai

description: Rhinobatos manai White, Last & Naylor, 2016b
Papuan Guitarfish
Rhinobatos manai White, Last & Naylor, 2016b: 589, Figs 1 –6. Holotype: NTUM 11500. Type locality: northwest of Kavieng, New Ireland, Papua New Guinea.
Local synonymy: Rhinobatos manai White et al., 2016b: 589, Figs 1 –6 (Kavieng, New Ireland); White et al., 2018: 206, figs (PNG).
PNG voucher material: (1 spec.) NTUM 11500, adult male 731 mm TL, northwest of Kavieng, New Ireland, 02°30’S, 150°44’E, 191–290 m depth, 7 Sep. 2014.
Remarks: Only known from a single specimen caught during deepwater surveys off New Ireland in 2014; recently described as a new species by White et al. (2016 b). Endemic to PNG.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on pages 48-49, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Vowel/Glide Alternation in a Theory of Constraint Interaction
Creators: name: Rosenthall, Samuel
Publisher: name: No Publisher Supplied
Year: 1994

description: This dissertation examines the distribution of high vowels and glides using Prince and Smolensky's Optimality Theory, which proposes that phonological constraints are violable and hierarchically ranked. The distribution of high vowels and glides is shown to be a consequence of simultaneously comparing moraic and nonmoraic syllabifications of high vowels for satisfaction of phonological constraints. In brief, a high vowel surfaces when the moraic parse best satisfies the constraints and a glide surfaces when the nonmoraic parse best satisfies the constraints. This dissertation investigates three main phenomena associated with the distribution of high vowels and glides.First, it treats the syllabification of vowel sequences in a number of languages with only surface monophthongal vowels. In Etsako, Luganda,Kimatuumbi, and Ilokano, high vocoids are syllabified as vowels when followed by a consonant, but they are syllabified as their nonmoraic counterparts when followed by another vowel. Furthermore, the syllabification of non high vowels varies across these languages. The syllabification of vowel sequences is shown to follow from the interaction of syllable structure constraints that ensure the surface vowel is a monophthong. The interlinguistic variation in syllabification is shown to follow from different rankings of the same set of syllable structure constraints. Second, stress can influence the distribution of high vowels. In Lenakel and Spanish, the generalization is that a high vocoid adjacent to a non high vowel is a vowel when stressed; otherwise it is a glide. This generalization implies that stress placement must be known prior to syllabification, which is problematic in procedural approaches to constituent construction, where syllabification must precede metrification. In the Optimality-Theoretic approach, the distribution of high vowels is determined by simultaneously best satisfying the metrical and the syllable structure constraints. Third, the distribution of high vowels and glides cannot always be attributed to an alternation between underlying vowels and glides. In a language like Berber, glides must be present underlyingly, and these underlying glides can alternate with high vowels. This is often called glide vocalization.  The alternation between underlying glides and high vowels in Berber is also shown to be the result of constraint interaction. In this case, moraic and nonmoraic syllabifications of the underlying glide are compared for constraint satisfaction.
Targeting MYC in Human Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The MYC proto-oncogene is an essential gene that plays a key role in mammalian cell proliferation. As a transcription factor MYC regulates expression of nearly 1/3 of the genes in the human genome. Abnormal MYC amplification has been found in ~50% of human breast cancers including those that are hormone receptor-negative. MYC amplification has also been linked to resistance to the existing therapies and to decreased breast cancer patients’ survival. However, no targeted therapy currently exists to treat these difficult-to-cure breast cancers with high MYC levels. We recently discovered a “synthetic-lethality” in which CDK1 inhibition using a small molecule inhibitor sensitized a variety of cells engineered to over-express MYC to undergo apoptosis while normal cells are spared. This raises the possibility that essential gene products including those, like MYC, that cannot be directly targeted may be able to be “indirectly” targeted in drug-based cancer therapeutics. This proposed research seeks to establish CDK1 inhibition as a novel approach to specifically target breast cancer cells with high MYC levels.

 We seek to test the hypothesis that MYC level predicts the responsiveness of breast cancers to CDK1 inhibition. The first aim is to define the correlation between MYC levels and the effectiveness of CDK1 inhibition in killing human breast cancer cells. The next aim is to analyze the mechanism by which CDK1 inhibition induces cell death. Finally, we plan to study the signaling mechanism that controls CDK1 inhibition-induced apoptosis in breast cancer cells with high MYC levels. For these studies, I will use a collection of 51 breast lines established from human primary breast tumors. We believe that the use of these cell lines allows us to examine our hypothesis in the context of heterogeneous human breast cancers, and that the outcomes will be more translatable into developing novel treatment strategies. Our technologies and functional studies include: (1) a high-throughput cell viability assay to define the correlation between MYC level and the response to CDK1 inhibition in inducing cell death, (2) a variety of cell-based assays to examine the modes of cell death, and (3) the function of apoptotic proteins and the signaling pathways that regulate them in CDK1 inhibition-induced apoptosis in breast cancer cells with high MYC.

 Myc-over-expression has been implicated in breast tumor formation and their maintenance, and it is correlated with decreased patient survival. Thus, investigating this novel synthetic lethality between MYC levels and CDK1 inhibition in breast cancer cells may lead to the development of novel therapeutic approaches for the treatment of “difficult-to-cure” human breast cancers with high MYC.