cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Recovery of Sparse Positive Signals on the Sphere from Low Resolution Measurements
Creators: name: Bendory, Tamir
name: Eldar, Yonina C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This letter considers the problem of recovering a positive stream of Diracs on a sphere from its projection onto the space of low-degree spherical harmonics, namely, from its low-resolution version. We suggest recovering the Diracs via a tractable convex optimization problem. The resulting recovery error is proportional to the noise level and depends on the density of the Diracs. We validate the theory by numerical experiments.
An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1
Creators: name: O'Kelly, Michael
name: Wilson, Richard K.
name: Hoadley, Katherine A.
name: Getz, Gad
name: Feiler, Heidi S.
name: Sarkaria, Jann N.
name: Purdom, Elizabeth
name: Hayes, D. Neil
name: Gabriel, Stacey
name: Speed, Terence P.
name: Verhaak, Roel G.W.
name: Meyerson, Matthew
name: Spellman, Paul T.
name: Alexe, Gabriele
name: Wilkerson, Matthew D.
name: Brennan, Cameron
name: James, C. David
name: Wang, Victoria
name: Mesirov, Jill P.
name: Gray, Joe W.
name: Gupta, Supriya
name: Jakkula, Lakshmi
name: Kahn, Ari
name: Tamayo, Pablo
name: Golub, Todd
name: Miller, C. Ryan
name: Perou, Charles M.
name: Lawrence, Michael
name: Ding, Li
name: Hodgson, J. Graeme
name: Qi, Yuan
name: Winckler, Wendy
name: Weir, Barbara A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical and Mesenchymal subtypes and integrate multi-dimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define Classical, Mesenchymal, and Proneural, respectively. Gene signatures of normal brain cell types show a strong relation between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype with greatest benefit in Classical and no benefit in Proneural. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
title: Diagnostic imaging in child abuse: Shatter the silence
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Extremities
subject: Forensic / Necropsy studies
subject: Paediatric
subject: CT
subject: Plain radiographic studies
subject: Education
subject: History
subject: Acute
subject: Forensics

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describing the classical imaging features in case of child abuse, favoring an appropriate and timely diagnosis and thus preventing the affected children from further emotional and physical...
Trends in recurrence analysis of dynamical systems
Creators: name: Marwan, Norbert
name: Kraemer, K. Hauke
Publisher: name: arXiv
Year: 2024
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Computational Physics (physics.comp-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: The last decade has witnessed a number of important and exciting developments that had been achieved for improving recurrence plot based data analysis and to widen its application potential. We will give a brief overview about important and innovative developments, such as computational improvements, alternative recurrence definitions (event-like, multiscale, heterogeneous, and spatio-temporal recurrences) and ideas for parameter selection, theoretical considerations of recurrence quantification measures, new recurrence quantifiers (e.g., for transition detection and causality detection), and correction schemes. New perspectives have recently been opened by combining recurrence plots with machine learning. We finally show open questions and perspectives for futures directions of methodical research.
description: 34 pages, 14 figures, 1 table
$(β)$-distortion of some infinite graphs
Creators: name: Baudier, Florent P.
name: Zhang, Sheng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Metric Geometry (math.MG)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46B85, 46B80, 46B20

description: A distortion lower bound of $Ω(\log(h)^{1/p})$ is proven for embedding the complete countably branching hyperbolic tree of height $h$ into a Banach space admitting an equivalent norm satisfying property $(β)$ of Rolewicz with modulus of power type $p\in(1,\infty)$ (in short property ($β_p$)). Also it is shown that a distortion lower bound of $Ω(\ell^{1/p})$ is incurred when embedding the parasol graph with $\ell$ levels into a Banach space with an equivalent norm with property ($β_p$). The tightness of the lower bound for trees is shown adjusting a construction of Matoušek to the case of infinite trees. It is also explained how our work unifies and extends a series of results about the stability under nonlinear quotients of the asymptotic structure of infinite-dimensional Banach spaces. Finally two other applications regarding metric characterizations of asymptotic properties of Banach spaces, and the finite determinacy of bi-Lipschitz embeddability problems are discussed.
description: This article supersedes arXiv:1411.3915 from the first author, 21 pages
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Creators: name: Buckley, Jonathan
name: Ding, Li
name: Pan, Fei
name: Cope, Leslie M.
name: Pelloski, Christopher E.
name: Diefes, Kristin
name: Hoadley, Katherine A.
name: Berman, Benjamin P.
name: Baylin, Stephen B.
name: Laird, Peter W.
name: Shen, Hui
name: Pujara, Kanan
name: Verhaak, Roel G.W.
name: Bengtsson, Henrik
name: Weisenberger, Daniel J.
name: Van Den Berg, David
name: Schmidt, Heather K.
name: Bhat, Krishna P.
name: Perou, Charles M.
name: Hayes, D. Neil
name: Wilson, Richard K.
name: Herman, James G.
name: Noushmehr, Houtan
name: Sulman, Erik P.
name: Aldape, Kenneth
name: Neuvial, Pierre
name: Phillips, Heidi S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG Island Methylator Phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the Proneural subgroup, are more prevalent among low-grade gliomas, display distinct copy-number alterations and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.
Fluorescence microscopy of neutrophils treated with manganese; Structure of profilin-1 from Neutrophil attachment via Mac-1 (αMβ2; CD11b/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3
Creators: name: Neeli, Indira
name: Moarefian, Maryam
name: Kuseladass, Jayalakshmi
name: Dwivedi, Nishant
name: Jones, Caroline
name: Radic, Marko
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Structural Biology

description: Neutrophil adhesion to endothelia, entry into tissues, and chemotaxis constitute essential steps in the immune response to infections that drive inflammation. Neutrophils bind to other cells and migrate via adhesion receptors, notably the αMβ2 integrin dimer (also called Mac-1, CR3 or CD11b/CD18). Here, the response of neutrophils to integrin engagement was examined by monitoring the activity of peptidylarginine deiminase 4 (PAD4). Histone H3 deimination was strongly stimulated by manganese, an integrin-activating divalent cation, even in the absence of additional inflammatory stimuli. Manganese-induced cell attachment resulted in neutrophil swarm formation that paralleled histone deimination, whereas antibodies that impair integrin binding prevented both cell adhesion and histone deimination. Manganese treatment led to putative deimination of profilin, a protein that functions as an actin-organizing hub, as detected by two-dimensional gel electrophoresis and citrulline immunoblotting. Cl-amidine, a covalent inhibitor of PAD4, and GSK484, a specific PAD4 inhibitor, blocked profilin deimination. Neutrophil migration toward leukotriene B4 and toward synovial fluid from a rheumatoid arthritis patient were inhibited by chloramidine, thus supporting the contribution of deimination to chemotaxis. The data, based on a simplified system for integrin activation, imply a mechanism whereby integrin attachment coordinates neutrophil responses to inflammation and orchestrates deimination of nuclear and cytoskeletal proteins.This article is part of the Theo Murphy meeting issue ‘The virtues and vices of protein citrullination’.
(401887) James Lyell Tombazis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
Creators: name: Walton, Zandra E.
name: Ji, Hongbin
name: Rikova, Klarisa
name: Shapiro, Geoffrey I.
name: Shimamura, Takeshi
name: Wong, Kwok Kin
name: Jackson, Autumn L.
name: Crosby, Katherine
name: Sanofsky, Benjamin A.
name: Brandstetter, Kathleyn A.
name: Hayes, Neil D.
name: Buttarazzi, Matthew S.
name: García-Echeverría, Carlos
name: Engelman, Jeffrey A.
name: McNamara, Kate L.
name: Kim, William Y.
name: Maira, Sauveur Michel
name: Bardeesy, Nabeel
name: Castrillon, Diego H.
name: Kim, Carla F.
name: Wilkerson, Matthew D.
name: Borgman, Christa L.
name: Sharpless, Norman E.
name: Carretero, Julian
name: Gu, Ting Lei
name: Silva, Jeffrey C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles and have identified gene and phosphoprotein signatures associated with Lkb1 loss and progression to invasive and metastatic lung tumors. These studies revealed that SRC is activated in Lkb1 deficient primary and metastatic lung tumors and that the combined inhibition of SRC, PI3K and MEK1/2 resulted in synergistic tumor regression. These studies demonstrate that integrated genomic and proteomic analyses can be used to identify signaling pathways that may be targeted for treatment.
(401884) Mary Elizabeth Frances MacDuff
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Material and Methods from Nineteenth-century collapse of a benthic marine ecosystem on the open continental shelf
Creators: name: Tomašových, Adam
name: Kidwell, Susan M.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Material and Methods with supplementary figures, tables, and age data
Convolutional Transformer-Based Image Compression
Creators: name: Arezki, Bouzid
name: Feng, Fangchen
name: Mokraoui, Anissa
Publisher: name: arXiv
Year: 2024
Subjects: subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we present a novel transformer-based architecture for end-to-end image compression. Our architecture incorporates blocks that effectively capture local dependencies between tokens, eliminating the need for positional encoding by integrating convolutional operations within the multi-head attention mechanism. We demonstrate through experiments that our proposed framework surpasses state-of-the-art CNN-based architectures in terms of the trade-off between bit-rate and distortion and achieves comparable results to transformer-based methods while maintaining lower computational complexity.
description: Published in: IEEE Signal Processing: Algorithms, Architectures, Arrangements, and Applications (SPA) 2023 Poznan, Poland
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Creators: name: Wang, Pu
name: Ito, Shinsuke
name: Xiong, Yue
name: Liu, Li Xia
name: Yang, Ying
name: Xu, Wei
name: Zhang, Yi
name: Zhang, Jin Ye
name: Liu, Jing
name: Wang, Bin
name: Guan, Kun Liang
name: Lei, Qun Ying
name: Zhao, Shi Min
name: Xu, Yan Hui
name: Liu, Ying
name: Yang, Hui
name: Yang, Chen
name: Xiao, Meng Tao
name: Jiang, Wen Qing
name: Wang, Ping
name: Frye, Stephen
name: Kim, Se Hee
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-hydroxyglutarate (2-HG), respectively. Here we demonstrate that 2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. 2-HG occupies the same space as α-KG does in the active site of histone demethylases. Ectopic expression of tumor-derived IDH1 and IDH2 mutants inhibits histone demethylation and 5mC hydroxylation. In glioma, IDH1 mutations are associated with increased histone methylation and decreased 5-hydroxylmethylcytosine (5hmC). Hence, tumor-derived IDH1 and IDH2 mutations reduce α-KG and accumulate an α-KG antagonist, 2-HG, leading to genome-wide histone and DNA methylation alterations.
Electronic supplementary material Schlaich et al. from A circannual perspective on daily and total flight distances in a long-distance migratory raptor, the Montagu's harrier Circus pygargus.
Creators: name: Schlaich, Almut E.
name: Bouten, Willem
name: Bretagnolle, Vincent
name: Heldbjerg, Henning
name: Klaassen, Raymond H. G.
name: Sørensen, Iben H.
name: Villers, Alexandre
name: Both, Christiaan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: A circannual perspective on daily and total flight distances in a long-distance migratory raptor, the Montagu's harrier Circus pygargus
A simple sampler for the horseshoe estimator
Creators: name: Makalic, Enes
name: Schmidt, Daniel F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: In this note we derive a simple Bayesian sampler for linear regression with the horseshoe hierarchy. A new interpretation of the horseshoe model is presented, and extensions to logistic regression and alternative hierarchies, such as horseshoe$+$, are discussed. Due to the conjugacy of the proposed hierarchy, Chib's algorithm may be used to easily compute the marginal likelihood of the model.
(401885) Ursula Edith MacDuff
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An Animal Model of MYC-Driven Medulloblastoma
Creators: name: Wang, Jun
name: Westbrook, Thomas F.
name: Miller, C. Ryan
name: Korshunov, Andrey
name: McLendon, Roger E.
name: Febbo, Phillip G.
name: Witt, Hendrik
name: Tewari, Alok K.
name: Cho, Yoon Jae
name: Buckley, Anne F.
name: Taylor, Michael D.
name: Moore, Colin E.
name: Northcott, Paul A.
name: Pfister, Stefan M.
name: Eroshkin, Alexey
name: Pei, Yanxin
name: Wechsler-Reya, Robert J.
name: Read, Tracy Ann
name: Schmitt, Earlene M.
name: Sun, Julia L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of the disease. Here we show that cerebellar stem cells expressing Myc and mutant Trp53 (p53) generate aggressive tumors following orthotopic transplantation. These tumors consist of large, pleiomorphic cells and resemble human MYC-driven MB at a molecular level. Notably, antagonists of PI3K/mTOR signaling, but not Hedgehog signaling, inhibit growth of tumor cells. These findings suggest that cerebellar stem cells can give rise to MYC-driven MB, and identify a novel model that can be used to test therapies for this devastating disease.
Geodesics in generalized Finsler spaces: singularities in dimension two
Creators: name: Remizov, A. O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53B40, 53C22, 34C05

description: We study singularities of geodesics flows in two-dimensional generalized Finsler spaces (pseudo-Finsler spaces). Geodesics are defined as extremals of a certain auxiliary functional whose non-isotropic extremals coincide with extremals of the action functional. This allows to consider isotropic lines as (unparametrized) geodesics.
title: Imaging of Alzheimer’s disease: Remember the times!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Nuclear medicine
subject: MR
subject: MR-Functional imaging
subject: PET
subject: Comparative studies
subject: Computer Applications-Detection, diagnosis
subject: Experimental investigations
subject: Dementia
subject: Geriatrics

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describing and exploring the various advances in imaging of Alzheimer’s disease including the magnetic resonance(MR) and positron emission tomography(PET). Aiding in early diagnosis, thus achieving appropriate and timely medical...
Lessons Learned from Applying Social Network Analysis on an Industrial Free/Libre/Open Source Software Ecosystem
Creators: name: Teixeira, Jose
name: Robles, Gregorio
name: González-Barahona, Jesús
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences
subject: D.2.9; K.6.3; K.6.4

description: Many software projects are no longer done in-house by a single organization. Instead, we are in a new age where software is developed by a networked community of individuals and organizations, which base their relations to each other on mutual interest. Paradoxically, recent research suggests that software development can actually be jointly-developed by rival firms. For instance, it is known that the mobile-device makers Apple and Samsung kept collaborating in open source projects while running expensive patent wars in the court. Taking a case study approach, we explore how rival firms collaborate in the open source arena by employing a multi-method approach that combines qualitative analysis of archival data (QA) with mining software repositories (MSR) and Social Network Analysis (SNA). While exploring collaborative processes within the OpenStack ecosystem, our research contributes to Software Engineering research by exploring the role of groups, sub-communities and business models within a high-networked open source ecosystem. Surprising results point out that competition for the same revenue model (i.e., operating conflicting business models) does not necessary affect collaboration within the ecosystem. Moreover, while detecting the different sub-communities of the OpenStack community, we found out that the expected social tendency of developers to work with developers from same firm (i.e., homophily) did not hold within the OpenStack ecosystem. Furthermore, while addressing a novel, complex and unexplored open source case, this research also contributes to the management literature in coopetition strategy and high-tech entrepreneurship with a rich description on how heterogeneous actors within a high-networked ecosystem (involving individuals, startups, established firms and public organizations) joint-develop a complex infrastructure for big-data in the open source arena.
description: As accepted by the Journal of Internet Services and Applications (JISA)
LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
Creators: name: Ollila, David W.
name: Shimamura, Takeshi
name: Roadcap, David W.
name: Sorrentino, Jessica
name: Miller, C. Ryan
name: Castrillon, Diego H.
name: Perou, Charles M.
name: Chan, Keefe T.
name: Sharpless, Norman E.
name: Pfefferle, Adam D.
name: Bear, James E.
name: Liu, Wenjin
name: Thomas, Nancy E.
name: Monahan, Kimberly B.
name: Wong, Kwok Kin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Germline mutations in LKB1 (STK11) are associated with the Peutz-Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (±p53 loss) in murine melanocytes, we observed variably pigmented and highly metastatic melanoma with 100% penetrance. LKB1 deficiency resulted in increased phosphorylation of the SRC family kinase (SFK) YES, increased expression of WNT target genes, and expansion of a CD24+ cell population, which showed increased metastatic behavior in vitro and in vivo relative to isogenic CD24− cells. These results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24+ tumor subpopulation.
МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКОЙ ХАРАКТЕРИСТИКИ ИЗОЛЯТОВ ВИРУСА БЕШЕНСТВА В РЕСПУБЛИКЕ ТАДЖИКИСТАН
Creators: name: Базаров, Мурат
name: Собиров, Илхомжон
name: Солиев, Бахтиёржан
name: Тожибаева, Мохларойим
name: Вазиров, Шерали
Publisher: name: Zenodo
Year: 2023

description: В статье обобщены результаты изучение молекулярно-генетической характеристики изолятов вируса бешенства в республике Таджикистан.
Pope Gregory XIII gave us the leap year – but his legacy goes much further
Creators: name: von Guttner Sporzynski, Darius
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 430314
subject: History of religion
classificationCode: 439999
subject: Other history, heritage and archaeology not elsewhere classified

description: This article explores the legacy of Pope Gregory XIII, best known for reforming the calendar to create the Gregorian system still in use today. The reform corrected inaccuracies in the Julian calendar by adjusting the leap-year system and realigning the calendar with the solar year. Beyond this achievement, Gregory XIII made significant contributions to Catholic Church reforms following the Council of Trent, urban development in Rome, and the codification of canon law. His tenure was characterised by intellectual engagement, centralisation of Church governance, and the commissioning of artistic works that reflected the triumph of Christianity. His enduring influence is reflected in both religious and cultural history.
title: Relationship between 2D- Shear wave velocity (SWV) and Serum biomarkers of liver function in patients with various chronic hepatitis
Creators: name: Inakami, Aya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Liver
subject: Elastography
subject: Ultrasound
subject: Biopsy
subject: Cirrhosis

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Chronic liver disease affects millions of people worldwide. [1] It encompasses many disease etiologies with viral hepatitis (chronic hepatitis B(CHB), chronic hepatitis C(CHC)), alcohol-induced (ALD), and non-alcoholic fatty liver disease (NAFLD)....
(401886) Gwen Hewett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Superconducting single photon detectors integrated with diamond nanophotonic circuits
Creators: name: Rath, Patrik
name: Kahl, Oliver
name: Ferrari, Simone
name: Sproll, Fabian
name: Lewes-Malandrakis, Georgia
name: Brink, Dietmar
name: Ilin, Konstantin
name: Siegel, Michael
name: Nebel, Christoph
name: Pernice, Wolfram
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Photonic quantum technologies promise to repeat the success of integrated nanophotonic circuits in non-classical applications. Using linear optical elements, quantum optical computations can be performed with integrated optical circuits and thus allow for overcoming existing limitations in terms of scalability. Besides passive optical devices for realizing photonic quantum gates, active elements such as single photon sources and single photon detectors are essential ingredients for future optical quantum circuits. Material systems which allow for the monolithic integration of all components are particularly attractive, including III-V semiconductors, silicon and also diamond. Here we demonstrate nanophotonic integrated circuits made from high quality polycrystalline diamond thin films in combination with on-chip single photon detectors. Using superconducting nanowires coupled evanescently to travelling waves we achieve high detection efficiencies up to 66 % combined with low dark count rates and timing resolution of 190 ps. Our devices are fully scalable and hold promise for functional diamond photonic quantum devices.
description: 28 pages, 5 figures
Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer
Creators: name: Egan, Sean E.
name: Zhao, Wei
name: Zacksenhaus, Eldad
name: Beyene, Joseph
name: Usary, Jerry
name: Xu, Keli
name: Ling, Vicki
name: Leong, Wey L.
name: Perou, Charles M.
name: Gridley, Tom
name: Guidos, Cynthia J.
name: Loch, Amanda J.
name: Yoon, Keejung
name: Gaiano, Nicholas
name: Wang, Wei
name: Prat, Aleix
name: Wang, Dong Yu
name: Adams, Jessica R.
name: Kousis, Philaretos C.
name: Deng, Tao
name: Cardiff, Robert Darrell
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary gland, while suppressing stem cell self-renewal. Here we show that deletion of Lfng, a sugar transferase that prevents Notch activation by Jagged ligands, enhances stem/progenitor cell proliferation. Mammary-specific deletion of Lfng induces basal-like and claudin-low tumors with accumulation of Notch intracellular domain fragments, increased expression of proliferation-associated Notch targets, amplification of the Met/Caveolin locus, and elevated Met and Igf-1R signaling. Human BL breast tumors, commonly associated with JAGGED expression, elevated MET signaling, and CAVEOLIN accumulation, express low levels of LFNG. Thus, reduced LFNG expression facilitates JAG/NOTCH luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote BLBC.
title: Physical assumptions behind ultrasound artifacts
Creators: name: Carvalho Almeida, Pedro
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Ultrasound physics
subject: Ultrasound
subject: Education
subject: Artifacts

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To discuss and explain the physics beyond the most common artifacts in B-mode. To illustrate and show how to interpret them to improve image quality and diagnostic...
Large GCD sums and extreme values of the Riemann zeta function
Creators: name: Bondarenko, Andriy
name: Seip, Kristian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11M06, 11C20

description: It is shown that the maximum of $|ζ(1/2+it)|$ on the interval $T^{1/2}\le t \le T$ is at least $\exp\left((1/\sqrt{2}+o(1)) \sqrt{\log T \log\log\log T/\log\log T}\right)$. Our proof uses Soundararajan's resonance method and a certain large GCD sum. The method of proof shows that the absolute constant $A$ in the inequality \[ \sup_{1\le n_1
description: This is the final version of this paper, to appear in Duke Math. J
ЭПИЗООТОЛОГИЧЕСКИЕ  АСПЕКТЫ  БЕШЕНСТВА  В РАЙОНАХ  РЕСПУБЛИКАНСКОГО ПОДЧИНЕНИЯ (РРП) ТАДЖИКИСТАНА
Creators: name: Базаров, Мурат
name: Собиров, Илхомжон
name: Солиев, Бахтиёржан
name: Сотволдиев, Карим
name: Вазиров, Шерали
Publisher: name: Zenodo
Year: 2023

description: В статье обобщены результаты изучение Эпизоотической ситуации бешенство на территории Районах Республиканского Подчинения (РРП). Бешенство наблюдается ежегодно, с интенсивностью, в среднем 31,27 случая в год. В период с 1991 по 2022 года во всех районах республиканского подчинения, а также в г. Душанбе были зарегистрированы случаи бешенства животных. Большинство случаев болезни наблюдались в районах Рудаки, Файзабад и в городах Душанбе и Вахдат. Установлена тенденция увеличения случаев бешенства в зимне-весенний период года. Чаще всего болезнь регистрирована среди собак, КРС, ослов и лисиц.
Electronic supplementary material Schlaich et al. from A circannual perspective on daily and total flight distances in a long-distance migratory raptor, the Montagu's harrier Circus pygargus
Creators: name: Schlaich, Almut E.
name: Bouten, Willem
name: Bretagnolle, Vincent
name: Heldbjerg, Henning
name: Klaassen, Raymond H. G.
name: Sørensen, Iben H.
name: Villers, Alexandre
name: Both, Christiaan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: A circannual perspective on daily and total flight distances in a long-distance migratory raptor, the Montagu's harrier Circus pygargus
Unificación de criterios y elaboración de documentos de ayuda para el desarrollo del TFM en el Master de Profesorado en la especialidad de Educación Física.
Creators: name: García-González, Luis
name: Abós, Ángel
Publisher: name: Zenodo
Year: 2023
Subjects: Trabajo Fin de Master, Educación Física

description: La elaboración del Trabajo Fin de Master (TFM) de la titulación es uno de los trabajos individuales que el estudiante elabora de mayor envergadura, con un total de 6 créditos en el Master de Profesorado. Dentro de esta asignatura el alumno tiene la posibilidad de elegir la realización de un TFM de la modalidad B, que consiste en un trabajo de iniciación a la investigación. Para su elaboración, el alumnado elige una línea temática ofrecida por un profesor tutor en la que realizar esta investigación. Sin embargo, la carga lectiva focalizada hacia la investigación es escasa en este Master, con menos de 3 créditos, lo que supone que los tutores deban realizar formación específica para una correcta elaboración del TFM, y eso, además de la carga de trabajo extra que supone, en ocasiones genera discrepancias en la estructura y contenido que este trabajo debe desarrollar. La falta de elementos y criterios unificados entre docentes, afecta de forma negativa en el alumnado y su satisfacción con la titulación al ser aplicados distintos criterios y formas de proceder. Por todo ello, parece necesario unificar entre el profesorado cuáles deben ser los elementos que deben componer el TFM de modalidad B. Además, para reducir la excesiva carga de trabajo que supone dirigir este tipo de TFM de iniciación a la investigación, parece necesario elaborar un texto docente con pautas y recomendaciones para la escritura de documento académico y científico que facilite la labor de los tutores, reduciendo su carga de trabajo, y que facilite también el trabajo del alumnado, con explicaciones argumentadas y ejemplos prácticos aclaratorios sobre algunas preguntas y dudas que habitualmente se repiten: contenido y estructura del trabajo, cómo realizar búsquedas bibliográficas especializadas en bases de datos científicas, cómo elaborar un problema de investigación suficientemente fundamentado, cómo abordar metodológicamente un trabajo de investigación en el ámbito de la Educación Física, como analizar de forma cuantitativa y cualitativa los datos recogidos en una investigación, cómo plantear de forma correcta y argumentada la discusión de los resultados, cómo elaborar las conclusiones, así como identificar cuáles son las principales limitaciones que ha tenido este trabajo. Por tanto, este proyecto de innovación plantea dos resultados y mejoras principales: 1.- Elaborar documentos para guiar al estudiantado en la elaboración de su TFM. 2.- Elaborar un texto docente con orientaciones y recomendaciones para cada uno de los apartados del TFM que sirva de guía para el alumnado y facilite la labor de los docentes.
description: Financiado por el Programa de Incentivación de la Innovación Docente de la Universidad de Zaragoza – PIIDUZ 379
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Creators: name: Bataller, Ramon
name: Rabadan, Raul
name: Gwak, Geum Youn
name: Caviglia, Jorge M.
name: Jang, Myoung Kuk
name: Bower, Maureen
name: Khiabanian, Hossein
name: Pradere, Jean Philippe
name: Friedman, Richard
name: Mencin, Ali
name: Sartor, R. Balfour
name: Dapito, Dianne H.
name: Mederacke, Ingmar
name: Lefkowitch, Jay H.
name: Schwabe, Robert F.
name: Adeyemi, Adebowale
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the hypothesis that the intestinal microbiota and Toll-like receptors (TLRs) promote hepatocellular carcinoma (HCC), a long-term consequence of chronic liver injury, inflammation and fibrosis. Hepatocarcinogenesis in chronically injured livers depended on the intestinal microbiota, and TLR4 activation in non-bone marrow-derived resident liver cells. TLR4 and the intestinal microbiota were not required for HCC initiation but for HCC promotion, mediating increased proliferation, expression of the hepatomitogen epiregulin, and prevention of apoptosis. Gut sterilization restricted to late stages of hepatocarcinogenesis reduced HCC suggesting that the intestinal microbiota and TLR4 represent therapeutic targets for HCC prevention in advanced liver disease.
title: Diagnosis of Cardiac Amyloidosis based on updated MR criteria: a 70-patient sample study
Creators: name: Oliveros Ordás, Patricia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: MR
subject: Contrast agent-intravenous
subject: Inflammation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Traditionally, the diagnosis of cardiac amyloidosis (CA) was based on histological amyloid deposition, demonstrated by invasive procedures like extra-cardiac or endomyocardial biopsy. More recently, a non-invasive approach for the diagnosis of...
title: Imaging of skull lesions : The calvarial calamities!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Head and neck
subject: Musculoskeletal bone
subject: CT
subject: Plain radiographic studies
subject: Diagnostic procedure
subject: Imaging sequences
subject: Cancer
subject: Congenital
subject: Dysplasias

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Calaverial lesions are usually asymptomatic and are usually discovered incidentally during CT and MRI of the brain. Calvaria lesions are benign and malignant but benign are more common than malignant lesions. Occasionally, they may present as a...
Supplementary material from “Optically-ambidextrous circularly-polarized reflection from the chiral cuticle of the scarab beetle Chrysina resplendens”.
Creators: name: Finlayson, Ewan D.
name: McDonald, Luke T.
name: Vukusic, Pete
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Figure S1 shows experimental measurements of circular polarization reflectance for a sample of eighty positions on the dorsal surface of the elytron. The results indicate that the main features of the CP spectra are consistently present across the sample of locations, and that some variation in the relative intensities and spectral positions of the features is observed. Figure S2 shows experimental measurements of circular polarization reflectance, performed on a prepared piece of elytron following removal of the endocuticle. Seven sets of measurements were made for incidence upon the dorsal surface and for incidence upon the exposed surface of the underside of the exocuticle. The results support the view that the spectra shown in figure 3b are typical of the exocuticle for incidence upon its exposed underside surface. The results also show that for incidence upon the dorsal surface the main spectral features seen in figure S1 were still observed following endocuticle removal. Figure S3 shows examples of SEM images of fractured sections of the exocuticle of the elytron. Figure S4 shows a schematic of the circular-polarization reflectance measurement setup.
Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
Creators: name: Wang, Ping
name: Xiong, Yue
name: Lei, Qun Ying
name: Guan, Kun Liang
name: Liu, Ying
name: Zhou, Xin
name: Xu, Yan Hui
name: Zhao, Di
name: Mo, Yan
name: Zou, Shao Wu
name: Dong, Bo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Tumor cells commonly have increased glucose uptake and lactate accumulation. Lactate is produced from pyruvate by lactate dehydrogenase A (LDH-A), which is frequently overexpressed in tumor cells and is important for cell growth. Elevated transcription by c-Myc or HIF1α may contribute to increased LDH-A in some cancer types. Here, we show that LDH-A is acetylated at lysine 5 (K5) and that this acetylation inhibits LDH-A activity. Furthermore, the K5-acetylated LDH-A is recognized by the HSC70 chaperone and delivered to lysosomes for degradation. Replacement of endogenous LDH-A with an acetylation mimetic mutant decreases cell proliferation and migration. Importantly, K5 acetylation of LDH-A is reduced in human pancreatic cancers. Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers.
(401889) Jessie Stenhouse
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Reflexive Pasts. Cultural Pragmatics, Identity Formation and the Roles of Social and Collective Memory
Creators: name: Mori, Luca
Publisher: name: QuiEdit
Year: 2015
Subjects: collective memory; flow; forgetting

description: Drawing on some theoretical stimuli provided by cultural sociology, the article will show how, when it
comes to discussing the identity-creating function of memory, focusing the analysis on the relationship
between representations of the past and the process of identity building is not enough. In addition, it is necessary to evaluate whether it is appropriate to include the consciousness (that here is assumed to be increasingly widespread) of the socially constructed nature of each identity in the concept of memory. In this case, memory would play an ambivalent role regarding identity. On the one hand, memory would represent a vital resource for its construction and retention, while on the other it could constitute an element making
actors aware of the artificiality of their selves, therefore ending up by playing a destabilizing role. Some consequences of this way of conceiving memory are discussed with regards to the general process of forgetting and the so-called ‘ethics of memory’.
description: Italian Sociological Review, Vol 1, No 3 (2011)
Optimum Bleaching Efficiency of Activated Ntezi Bentonite using Response Surface Methodology
Creators: name: Ajemba, Regina
name: Nweke, Chinenyenwa
name: John, Sunday
name: Ejiofor, Calista
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 400408
subject: Reaction engineering (excl. nuclear reactions)
classificationCode: 400499
subject: Chemical engineering not elsewhere classified

description: The optimization of the bleaching efficiency of acid-activated Ntezi bentonite was studied by reacting raw bentonite with different concentrations of hydrochloric acid solution for varying periods to activate it. The raw and activated samples were characterized using X-ray fl uorescence. The activated samples were used to bleach palm oil and the effects of bleaching process variables were investigated using the Response Surface Methodology (RSM). Results of the analysis showed that the structure of the bentonite was altered by the acid activation and this increased the adsorptive capacity of the activated samples. The statistical analysis indicated that the main and quadratic effects of the bleaching process parameters were signifi cant at the 95% confi dence level. The optimum conditions were determined to be: reaction temperature 156.66°C; reaction time, 2.74 hours; adsorbent dosage, 5.93 g; adsorbent/oil ratio, 0.04 g/ml; and stirring speed, 411.62 rpm. Under these conditions, the optimum bleaching effi ciency was determined to be 85.48%, which agreed with the experimental value of 86.07%. This study showed that Ntezi bentonite can be used as an effective adsorbent under optimized process conditions.
Measuring Non-linearity in AH 2700A Capacitance Bridges with sub-ppm level uncertainty
Creators: name: Imanaliev, Almazbek
name: Thévenot, Olivier
name: Dougdag, Kamel
name: Piquemal, François
Publisher: name: arXiv
Year: 2024
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: The stability and non-linearity of a commercial AH 2700A capacitance bridge were studied beyond its specified capabilities using the Thompson-Lampard Calculable Capacitor (TLCC) at LNE. The TLCC allows for continuous variation of measured capacitance between 0.4 pF and 1.2 pF with a resolution of 2 parts in $10^{7}$ and stability better than 1 part in $10^{9}$ over 2 days. The study aimed to determine root cause of the saw-tooth non-linearity pattern observed in the AH 2700A capacitance bridge. This pattern becomes apparent when the internal calibration is no longer valid, indicating deviations in the bridge circuit. Additionally, the dependence of capacitance non-linearity on various factors such as frequency and capacitance value are described. This work enables automatic calibration of the commercial bridge with an uncertainty of sub-ppm level and allows for quick evaluation of TLCC's non-linearity and monitoring of any changes over time through in-situ measurements.
(401882) Janet Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.