cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel thiosemicarbazones of coumarin incorporated isatins: synthesis, structural characterization and antileishmanial activity
Creators: name: Khatoon, Saira
name: Asif, Rabbia
name: Kalsoom, Saima
name: Aroosh, Aiman
name: Islam, Arshad
name: Tariq, Syeda Sumayya
name: Ul-Haq, Zaheer
name: Naseer, Muhammad Moazzam
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Leishmaniasis, a neglected tropical disease affecting 0.7 to 1.3 million people annually, has only a few toxic therapeutic options. This study describes the synthesis, structural characterization, in silico and in vitro assessment of novel thiosemicarbazones of coumarin incorporated isatins (6a–6m) as highly as potent and safe antileishmanial agents. Molecular docking was initially used to determine the binding of these compounds to the active cavity of the target protein (Leishmanolysin gp63) of Leishmania (L.) tropica. Among all the docked compounds, three 6d, 6f and 6l showed high binding affinities due to strong H-bonds and hydrophobic π-interactions. Importantly, the in vitro investigations of thirteen synthesized compounds for antileishmanial activity against L. tropica promastigotes and axenic amastigotes, complemented the docking results. The compound 6d was found to be the most active of the series at micromolar concentrations both against promastigotes (IC50 = 2.985 μmol/L) and axenic amastigotes (IC50 = 13.46 μmol/L) in comparison to the tarter emetic (IC50 = 12.56 μmol/L) and amphotericin B (IC50 = 1.826 μmol/L), respectively. Significantly, all active compounds are much less toxic as compared to the positive control (Triton X-100) and, tartar emetic (TA) and amphotericin B when screened for their toxicity against human erythrocytes. To gain further insight into the interaction dynamics of our target protein on binding with compound 6d, molecular dynamic simulation was performed for a course of 100 ns for both the apo-protein and the protein–ligand complex. The results revealed consistent structural stability for the protein–ligand complex, aligning with characteristics seen in the apo-proteins.
title: Stress Perception and Coping as Mediators of the Link Between Self-Compassion and Affective Well-being? Evidence From Two Longitudinal Studies
Creators: name: Ewert, Christina
name: Buechner, Anabel
name: Schröder-Abé, Michela
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: Self-compassion
subject: Stress
subject: Emotion regulation
subject: Affect
subject: Cross-lagged panel analysis
subject: Longitudinal
subject: 150 Psychologie

description: Objectives: A growing body of research has already demonstrated the link between self-compassion and improved affective well-being and mental health. Initial findings have indicated that effective stress processing might be a mechanism underlying the beneficial effects of self-compassion on mental health outcomes. However, studies are still quite limited as they have mostly been cross-sectional and often included specific samples only. Thus, this research examines perceived stress and coping as two key mechanisms underlying the relation between self-compassion and affective well-being longitudinally in two different samples. Method: In two longitudinal studies with three measurement waves each, we assessed self-compassion, perceived stress, engagement and disengagement coping, and affective well-being. Study 1 analyzed a student sample ( n  = 684) across 12 weeks. Study 2 followed a population-based sample ( n  = 2934) across a 4-month period. Results: Cross-lagged panel analyses indicated that perceived stress mediated the link between self-compassion and affective well-being in both longitudinal studies. Engagement coping responses mediated this link in Study 2. Disengagement coping responses did not act as mediators in both studies. Conclusions: Our work helps to better understand the processes underlying the link between self-compassion and well-being. Self-compassion might facilitate effective stress responses in terms of less perceived stress and more salutary coping responses, which in turn might help to enhance affective well-being. Preregistration: All hypotheses were preregistered (as well as design, and analyses for the second Study) online at the Open Science Framework before starting with data collection (see preregistration at: https://osf.io/fhm9q/?view_only=577dd62d2f5548d59ccf703ee1d0d0a6 ).
title: Cultural Influence of Local Food Heritage on Sustainable Development
Creators: name: Chukwurah, Gladys Ogochukwu
name: Okeke, Francis Ogochukwu
name: Isimah, Matthew Ogorchukwu
name: Enoguanbhor, Evidence Chinedu
name: Awe, Foluso Charles
name: Nnaemeka-Okeke, Rosemary Chidimma
name: Guo, Shuang
name: Nwafor, Ifeanyichukwu Valentine
name: Okeke, Chioma Angela
Publisher: name: Humboldt-Universität zu Berlin
Year: 2025
Subjects: subject: cultural heritage
subject: cultural values
subject: enugu region
subject: local food
subject: sustainability
subject: 300 Sozialwissenschaften

description: This article explores relations between cultural heritage and cultural values for sustainable development in the Enugu region. It discusses the potential to advance a cultural approach to sustainable development of regions by examining the cultural food heritage and relating it to cultural values. Based on empirical research, the article employed a mixed-methods approach to examine the relationship between the identified major local food heritage and cultural values for sustainable regional planning and development. The study examined primary data from 380 community elders, traders, and relevant institutions—including the Ministry of Arts and Culture and the Ministry of Agriculture—through interviews, participant observation, and questionnaires. Data were analyzed using SPSS and Pearson product–moment correlation. Findings identified eight local food heritages and six cultural values. The findings suggest that promoting and preserving local food heritage can be crucial in fostering sustainable cultural values and contributing to sustainable regional development. The local food had a statistically significant influence on cultural values. The Pearson correlation result ( p -value = 0.000) shows a strong correlation between the local food heritage and cultural values for sustainable regional planning and development. However, the study also identified several challenges threatening the sustainability of local food heritage in the region, including high costs, small-scale farming, insecurity, climate change, and poor transportation. The study recommends the development and implementation of comprehensive policies and programs that prioritize the preservation and promotion of local food heritage while addressing the identified challenges.
title: Can Law Students Replace Judges in Experiments of Judicial Decision-Making?
Creators: name: Spamann, Holger
name: Klöhn, Lars
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: judicial decision-making
subject: experiment
subject: methodology
subject: student subjects
subject: precedent effect
subject: bias
subject: 340 Recht

description: Experimental research on judicial decision-making is hampered by the difficulty of recruiting judges as experimental participants. Can students be used in judges’ stead? Unfortunately, no—at least if the objective is to study legal reasoning. We ran the same high-context 2 × 2 factorial experiment of judicial decision-making focused on legal reasoning with 31 U.S. federal judges and 91 elite U.S. law students. We obtained diametrically opposed results. Judges’ decisions were strongly associated with one factor (sympathy, i.e., bias) but not the other (law). For students, it was the other way around. Equality between the two groups is strongly rejected. Equality of document-view patterns—a proxy for thought processes—and written reasons is also strongly rejected.
A modified Bouc–Wen hysteresis model for predicting the behavior of the helical and wave springs
Creators: name: Zudov, Valerii
name: Prajapati, Mayur Jiyalal
name: Jeng, Jeng-Ywan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Today, an important task in additive manufacturing is a simulation of experiments to predict some item behavior and properties (such as hysteresis). Numerical simulations can be a time-consuming and computationally intensive to simulate even a simple structure such as a spring. To counter that, in this study, a modified Bouc–Wen mathematical model is created in MATLAB to simulate the hysteresis loop for the complex design of helical and wave springs which were constructed via additive manufacturing. A comparison was made with the previously developed finite element analysis framework of studies with springs. Fixed parameters of the model were selected for its versatility. Also, the sensitivity of the model due to the variation of each analytical parameter has been investigated. It was found that the analytical model was more accurate and consumed less time as compared to the finite element analysis simulations for structures such as springs. The current study lays the foundation for the development of similar analytical models for additively manufactured spring components to reduce the computational cost.
Prospective cohort study of voice outcomes following secondary tracheoesophageal puncture in gastric pull-up reconstruction after total laryngopharyngoesophagectomy
Creators: name: Deane, Emily C.
name: Parhar, Harman
name: Rammage, Linda
name: Hu, Amanda
name: Anderson, Donald W.
Publisher: name: BioMed Central
Year: 2021

description: Background: Gastric pull-up is a reconstructive option for circumferential defects after resection of advanced laryngopharyngeal malignancy. Voice loss is expected and vocal rehabilitation remains a challenge. Our study objectives were to investigate the feasibility of secondary tracheoesophageal puncture following gastric pull-up and to analyze voice outcomes. Methods: This was a prospective cohort study of patients with advanced laryngopharyngeal malignancies who underwent gastric pull-up and secondary tracheoesophageal puncture between 1988 and 2017 at a tertiary-care academic institution. Objective acoustic measures included fundamental frequency and vocal intensity. Perceptual analysis was performed using voice recordings (“Rainbow Passage”) randomly presented in a blinded fashion to four clinicians using the validated GRBAS scale. Speech intelligibility was assessed in a blinded fashion using a validated 7-point scale. Additionally, the Voice Handicap Index-10 was administered as a validated patient self-reporting tool. Results: Ten patients (7 male, 3 female) were included, all of whom preferentially used tracheoesophageal puncture for communication. These patients had abnormal median fundamental frequency of 250 (interquartile range (IQR) 214–265) Hz and a limited median vocal intensity of 65.8 (IQR 64.1–68.3) dB. Perceptual analysis (GRBAS) revealed a median ‘moderate’ degree of impairment [grade 2 (IQR 2–3), roughness 2 (IQR 2–3), breathiness 3 (IQR 2–3), asthenia 2 (IQR 1–2), strain 2 (IQR 1–2)] as did median intelligibility scores [median 5 (IQR 4–7)]. Most patients self-reported an abnormal voice handicap-10 [median 26.5 (IQR 22.8–35.0)]. Conclusion: Secondary tracheoesophageal puncture is a safe and feasible option for voice rehabilitation after gastric pull-up. Although analyses demonstrated moderate subjective and objective impairment, tracheoesophageal puncture provided patients with a self-reported means of functional verbal communication and was their preferred method of communication. Graphical abstract
Pachythelia villosella
Creators: name: Volkova, Julia S.
name: Prozorov, Alexey M.
name: Kryuchkov, Sergey N.
name: Pavlov, Pavel O.
name: Yakovlev, Roman V.
name: Anikin, Vasilii V.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Psychidae
Pachythelia
Pachythelia villosella

description: 19. Pachythelia villosella (Ochsenheimer, 1810)
(Figs 28)
 Material: ♂, Inza District, Yulovo, 53.963394N, 46.477890E, 6.VII.1993, V. V. Zolotuhin (Fig. 48, site 7).
 Biology. Inhabits open areas: dry meadows, slopes, steppes, roadsides, marshes in the altitudes up to 2000 m above sea level. Polyphagous, found on herbaceous plants and heathers (Ericaceae). Cases with pupating females are found on tree trunks; cases with males remain on the ground, which makes them difficult to find. Adults occur from the end of April until early July, active from the afternoon until the evening, attracted by light.
 Distribution in Russia. Recorded from almost everywhere, from the Republic of Karelian to South Ural Region (Sinev & Lovtsova 2019). In the Volga Region, it is known from the Ulyanovsk, Saratov, and Volgograd Oblasts, the Republics of Tatarstan and Chuvashia (Anikin et al. 2017).
description: Published as part of Volkova, Julia S., Prozorov, Alexey M., Kryuchkov, Sergey N., Pavlov, Pavel O., Yakovlev, Roman V. & Anikin, Vasilii V., 2022, Fauna of Psychidae (Lepidoptera) of the Ulyanovsk Oblast (Middle Volga, Russia), pp. 109-121 in Ecologica Montenegrina 58 on page 118, DOI: 10.37828/em.2022.58.10, http://zenodo.org/record/13241156
title: ÐÐ°Ð»ÐµÐ½Ð´Ð°ÑÐ½Ð¾Ðµ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ñ Microsoft Project
title: ÑÑÐµÐ±Ð½Ð¾-Ð¼ÐµÑÐ¾Ð´Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: Ð¦Ð²ÐµÑÐºÐ¾Ð²Ð°, ÐÐ°Ð´ÐµÐ¶Ð´Ð°
name: ÐÐ¾Ð»ÑÐ±ÐµÐ², Ð¡ÐµÑÐ³ÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2025
Subjects: ÐÑÑÐ¸ÑÐ»Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ð¼Ð°ÑÐ¸Ð½Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½ÑÐµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»ÑÐ½ÑÐµ
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ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ·Ð¾Ð²

description: Ð ÑÑÐµÐ±Ð½Ð¾-Ð¼ÐµÑÐ¾Ð´Ð¸ÑÐµÑÐºÐ¾Ð¼ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¾ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ Ð¿Ð¾ÑÑÐ´ÐºÐ° ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐºÐ°Ð»ÐµÐ½Ð´Ð°ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð»Ð°Ð½Ð° Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Microsoft Project. Ð¦ÐµÐ»Ñ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ°Ð±Ð¾Ñ â Ð¾ÑÐ²Ð¾ÐµÐ½Ð¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸Ðº ÐºÐ°Ð»ÐµÐ½Ð´Ð°ÑÐ½Ð¾-ÑÐµÑÐµÐ²Ð¾Ð³Ð¾ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¾ÑÑÐ»ÐµÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ ÑÐ°Ð±Ð¾Ñ Ð¿ÑÐ¾ÐµÐºÑÐ°, Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ð¾Ð² Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð»Ð°Ð½Ð¾Ð² ÑÐ°Ð±Ð¾Ñ Ð¿ÑÐ¾ÐµÐºÑÐ° Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ° Microsoft Project. ÐÑÑÑ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½ Ð´Ð»Ñ Ð¾Ð±ÑÑÐ°ÑÑÐ¸ÑÑÑ Ð¿Ð¾ Ð²ÑÐµÐ¼ Ð¿ÑÐ¾ÑÐ¸Ð»ÑÐ¼ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ¾Ð² Ð¸ Ð¼Ð°Ð³Ð¸ÑÑÑÐ¾Ð² Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÐÐ 27.03.05 Ð¸ 27.04.05 Â«ÐÐ½Ð½Ð¾Ð²Ð°ÑÐ¸ÐºÐ°Â» Ð¾ÑÐ½Ð¾Ð¹ Ð¸ Ð·Ð°Ð¾ÑÐ½Ð¾Ð¹ ÑÐ¾ÑÐ¼ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð»Ñ ÑÐ»ÑÑÐ°ÑÐµÐ»ÐµÐ¹, Ð¸Ð½ÑÐµÑÐµÑÑÑÑÐ¸ÑÑÑ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°Ð¼Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÐµÐºÑÐ°Ð¼Ð¸.
Migration ecology of western gray catbirds
Creators: name: Mancuso, Kristen A.
name: Fylling, Megan A
name: Bishop, Christine A
name: Hodges, Karen E.
name: Lancaster, Michael B
name: Stone, Katharine R
Publisher: name: BioMed Central
Year: 2021

description: Background: For many songbirds in North America, we lack movement details about the full annual cycle, notably outside the breeding season. Understanding how populations are linked spatially between breeding and overwintering periods (migratory connectivity) is crucial to songbird conservation and management. We assessed migratory connectivity for 2 breeding populations of Gray Catbirds (Dumetella carolinensis) west of and within the Rocky Mountains by determining migration routes, stopover sites, and overwintering locations. Additionally, we compared apparent annual survivorship for both populations. Methods: We deployed 39 archival light-level geolocators and 21 Global Positioning System (GPS) tags on catbirds in the South Okanagan Valley, British Columbia, Canada, and 32 geolocators and 52 GPS tags in the Bitterroot River Valley, Montana, USA. These devices allowed us to determine migration routes, stopover sites, overwintering locations, and migratory connectivity. Migratory connectivity was quantified using Mantel’s correlation. We used mark-recapture of colour banded catbirds in both sites to estimate apparent annual survivorship. Results: We retrieved 6 geolocators and 19 GPS tags with usable data. Gray Catbirds from both populations passed through the Rocky Mountains eastward before heading south towards their overwintering locations in northeastern Mexico and Texas. Stopover sites during fall migration occurred primarily in Montana, Kansas, Oklahoma, and Arkansas. Overwintering locations spanned Texas and 5 states in northeastern Mexico. Individual catbirds used up to 4 distinct sites during the overwintering period. Catbirds separated by almost 500 km during the breeding season overlapped during the non-breeding season, suggesting weak migratory connectivity among western populations (Mantel’s correlation = 0.013, P-value = 0.41). Catbird apparent annual survivorship estimates were higher in British Columbia (0.61 ± 0.06 females; 0.64 ± 0.05 males) than in Montana (0.34 ± 0.05 females; 0.43 ± 0.04 males), though the main driver of these differences remain unclear. Conclusions: Our results provide high precision geographic details during the breeding, migration, and overwintering phases of the annual cycle for western Gray Catbirds. Notably, we found that western catbirds followed the Central Flyway as opposed to the Pacific Flyway. We document that catbirds used multiple sites over winter, contrary to the popular belief that this phase of the annual cycle is stationary for most songbirds.
D10.2 Protocol-oncDST
Creators: name: Frederickx, Nancy
name: Van Valckenborgh, Els
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Next-Generation Sequencing (NGS)
subject: Cancer genomics
subject: Decision Support Tool (DST)
subject: oncology Decision Support Tool (oncDST)
subject: Decision Support Systems, Clinical
subject: Clinical Decision System
subject: Precision Oncology
subject: Clinical data integration
subject: Data interoperability
subject: Digital framework
subject: Molecular Tumour Board (MTB)
subject: MTB
subject: EU-oncDST concept
subject: oncDST
subject: CAN.HEAL
subject: EU4HEALTH
subject: Personalized medicine
subject: Public health genomics

description: Building upon the EU-oncDST concept introduced in Deliverable 10.1 of the CAN.HEAL project under the EU4Health Programme, Deliverable 10.2 presents a strategic action plan for its deployment across Europe. This digital framework aims to enhance clinical decision-making in oncology by improving the implementation and interoperability of existing oncDSTs, centralising patient data, encouraging collaboration among key stakeholders and fostering innovation.

The action plan presents a phased approach, initially focusing on a symbiotic relationship between molecular tumour boards (MTBs) deployment and the widespread implementation of oncDSTs. This phase includes validating the impact of oncDSTs through pilot applications in MTB settings and prioritising key areas such as improving patient-centred consultations, harmonising variant annotation, enhancing clinical trial matching, and supporting the broader adoption of the MTB module.

Furthermore, the action plan emphasizes the role of public-private partnerships and EU initiatives in facilitating the implementation of the oncDST concept, ultimately improving patient outcomes and advancing precision oncology in Europe.
ГИЁҲВАНДЛИК ВОСИТАЛАРИ, УЛАРНИНГ АНАЛОГЛАРИ ЁКИ ПСИХОТРОП МОДДАЛАРНИ ЎТКАЗИШ МАҚСАДИНИ КЎЗЛАМАЙ ҚОНУНГА ХИЛОФ РАВИШДА ТАЙЁРЛАШ, ЭГАЛЛАШ, САҚЛАШ, ТАШИШ ЁКИ ЖЎНАТИШ ЖИНОЯТИНИ ТЕРГОВ ҚИЛИШДА ҚЎШИБ ҲИСОБЛАШ  МЕТОДОЛОГИЯСИНИНГ АҲАМИЯТИ
Creators: name: Суюнов, Шахзод
Publisher: name: Zenodo
Year: 2025

description: Мақолада гиёҳвандлик воситалари, психотроп моддалар ва уларнинг аналоглари билан боғлиқ жиноятларни тергов қилишда мавжуд муаммолар, хусусан, турли хил моддаларни қўшиб ҳисоблаш методологиясининг йўқлигига бағишланган. Мақолада қиёсий-ҳуқуқий таҳлил, тизимли методлар ва статистик маълумотлар асосида илмий-амалий таклифлар ишлаб чиқилган. Хусусан, “Фоиз нисбати” методикаси орқали турли моддаларни қўшиб ҳисоблаш механизми таклиф қилиниб, бу усулнинг жиноий жавобгарликни аниқлашдаги самараси мисоллар билан асосланган. Халқаро тажриба, олимлар фикрлари ва амалий мисолларга таяниб, миллий қонунчиликка ўзгартиришлар киритиш тавсия этилган.
Application of the WebQual™ instrument to three Australian websites: does industry influence the relative importance of the dimensions of WebQual?
Creators: name: Carlson, Jamie
name: Voola, Ranjit
name: Sukunesan, Suku
Publisher: name: Swinburne
Year: 2024

description: Assessing the quality of a Website has received growing attention from academics and practitioners. The objective of this study is to apply the WebQualTM framework developed by Loiacono, Watson and Goodhue (2002) to determine whether any differences exist between three Australian industry groups across the Website Quality constructs. This study elineates the Website Quality model into its latent dimensions and examines for differences between three B2C Websites. This extends previous research on the WebQualTM instrument by presenting some preliminary findings in the Australian setting. Relevant implications for managing Website quality are highlighted, with directions for future research discussed.
Methodology for Building Synergies with European Initiatives: The BIOFIN-EU Perspective
Creators: name: Stogiannou, Eleni
Publisher: name: Zenodo
Year: 2025

description: This technical article describes coordinated steps and ways to reach out to projects and initiatives relevant to BIOFIN-EU’s objectives, through which synergies, exchanging good practices and providing evidence for EU policy developments will be enhanced. The expected common activities include joint dissemination and/or exploitation activities, as well as coordinated deliverables related to policy recommendations. This process aims to promote technological innovations, effective stakeholder engagement, while also enhancing crossproject learning, accelerating market uptake of results, enabling evidence-based policy development, and supporting long-term sustainability of outcomes. The methodology ensures impactful knowledge exchange,supports strategic policy alignment, and amplifies ecosystem-building efforts.

 

BIOFIN-EU, an R&I project funded by the EU, unites 13 experts from 10 countries to find financial solutions to address biodiversity loss and enhance nature conservation. The project redirects funds from harmful activities to nature-positive investments, promoting harmony between human actions and nature. BIOFIN-EU will develop a framework and technology to support large-scale investments in nature-based solutions (NbS), streamline decisions, and standardize investments. A data-driven dashboard will enhance project appraisal and risk assessment, aiding the EU's biodiversity goals. Case studies will identify gaps in the Sustainable Finance Taxonomy and inform policy recommendations.
Ptilocephala plumifera
Creators: name: Volkova, Julia S.
name: Prozorov, Alexey M.
name: Kryuchkov, Sergey N.
name: Pavlov, Pavel O.
name: Yakovlev, Roman V.
name: Anikin, Vasilii V.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Psychidae
Ptilocephala
Ptilocephala plumifera

description: 20. Ptilocephala plumifera (Ochsenheimer, 1810)
(Figs 23, 46)
 Material: ♂, Nikolaevka District, environs of the village Praskovyino, 53.136409N, 47.406954E, 5.V.1998, V. V. Zolotuhin (Fig. 48, site 11); ♂, Radishchevskoe District, station Ryabina, 52.913645N, 48.312420E, 29.IV–3.V.1996, D.Yu. Klevolgin (Fig. 48, site 16).
 Biology. Inhabits open landscapes both in xerotemporal and swampy areas. Adults occur from the end of April until June, active during daytime.
 Distribution in Russia. Recorded from everywhere, from the European Central to Southwest Siberian Regions (Sinev & Lovtsova 2008). In the Volga Region, it is known from Volgograd, Saratov, and Ulyanovsk Oblasts (Anikin et al. 2017).
description: Published as part of Volkova, Julia S., Prozorov, Alexey M., Kryuchkov, Sergey N., Pavlov, Pavel O., Yakovlev, Roman V. & Anikin, Vasilii V., 2022, Fauna of Psychidae (Lepidoptera) of the Ulyanovsk Oblast (Middle Volga, Russia), pp. 109-121 in Ecologica Montenegrina 58 on pages 119-120, DOI: 10.37828/em.2022.58.10, http://zenodo.org/record/13241156
Supplemental Tables and Figures from Slow improvement to the archiving quality of open datasets shared by researchers in ecology and evolution
Creators: name: Roche, Dominique G.
name: Berberi, Ilias
name: Dhane, Fares
name: Lauzon, Félix
name: Soeharjono, Sandrine
name: Dakin, Roslyn
name: Binning, Sandra A.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Table S1, Table S2, Figure S1, Figure S2, Figure S3, Figure S4
Hunting for Familial Parkinson’s Disease Mutations in the Post Genome Era
Creators: name: Bentley, Steven R.
name: Guella, Ilaria
name: Sherman, Holly E.
name: Neuendorf, Hannah M.
name: Sykes, Alex M.
name: Fowdar, Javed Y.
name: Silburn, Peter A.
name: Wood, Stephen A.
name: Farrer, Matthew J.
name: Mellick, George D.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Parkinson’s disease (PD) is typically sporadic; however, multi-incident families provide a powerful platform to discover novel genetic forms of disease. Their identification supports deciphering molecular processes leading to disease and may inform of new therapeutic targets. The LRRK2 p.G2019S mutation causes PD in 42.5–68% of carriers by the age of 80 years. We hypothesise similarly intermediately penetrant mutations may present in multi-incident families with a generally strong family history of disease. We have analysed six multiplex families for missense variants using whole exome sequencing to find 32 rare heterozygous mutations shared amongst affected members. Included in these mutations was the KCNJ15 p.R28C variant, identified in five affected members of the same family, two elderly unaffected members of the same family, and two unrelated PD cases. Additionally, the SIPA1L1 p.R236Q variant was identified in three related affected members and an unrelated familial case. While the evidence presented here is not sufficient to assign causality to these rare variants, it does provide novel candidates for hypothesis testing in other modestly sized families with a strong family history. Future analysis will include characterisation of functional consequences and assessment of carriers in other familial cases.
Blowing smoke: strategies smokers use to protect non-smokers from environmental tobacco smoke in the home
Creators: name: Hill, Lola
name: Farquharson, Karen
name: Borland, Ron
Publisher: name: Swinburne
Year: 2024

description: Issue addressed: Research has suggested that many smokers wish to protect the non-smokers they live with, particularly children, from exposure to their tobacco smoke. This study investigates the strategies smokers use to protect non-smokers from exposure to tobacco smoke in their homes, how effective they perceive these strategies to be, and what they perceive as obstacles to making their homes smoke-free. Methods: Audio-taped, face-to-face, semi-structured interviews were conducted with 20 Australian apartment dwelling smokers. We focused on smokers who live in apartments because the structural barriers they face in order to become smoke-free appear higher than those who live in houses. Apartments are also more likely to house socially disadvantaged people, people who research has shown are less likely to have smoke- free homes than the socially advantaged. Conclusions: Participants use two main strategies (opening windows, or smoking in a separate room). Other than factors such as lack of private outdoor space and nicotine dependence, participants reported that psychosocial factors, such as preferring to smoke in comfort and wanting to honour preferences of family and friends to smoke indoors, hinder their attainment of smoke- free homes.
title: Modelling floodplain vegetation responses to catchment hydrology under different climate change scenarios
Creators: name: Muhury, Newton
Publisher: name: University of Southern Queensland
Year: 2023
Subjects: classificationCode: 310301
subject: Behavioural ecology

description: The floodplain ecosystems are the most ecologically and economically significant areas increasingly becoming vulnerable and facing severe challenges due to climate change. Understanding how floodplain vegetation responds to changes in climate is essential for effective conservation and management strategies. This study was conducted in an Australian floodplain, with the following objectives: 1) to assess the relationship between surface water interannual variability and responses of different vegetation types in floodplain areas; 2) to evaluate the spatiotemporal impacts of groundwater dynamics on floodplain vegetation; and 3) to model floodplain vegetation responses under different climate change scenarios. To address the first objective, a hydrological model was set up in the Burrinjuck sub-catchment area and calibrated against daily rainfall and streamflow data to simulate catchment runoff. Model performance was evaluated against the Nash Sutcliffe Coefficient of efficiency (NSE) value of 0.95, indicating very good performance. The modelling results show high positive relationships (r=0.85, 0.82, and 0.81) between the observed and predicted NDVI values of grass-type vegetation (distant from the stream) against the rainfall, runoff, and streamflow, respectively, during the dry season. However, these relationships were reduced by 26.8% (r=0.60) and 33.33% (r=0.54) against runoff and streamflow during the wet season. For the second objective, different floodplain vegetation types in the study area were analysed against groundwater dynamics at the catchment level using ArcSWAT. The SWAT model was calibrated and validated in SWAT-CUP software using ten years (2001–2010) of monthly streamflow data. The modelling results show high positive relationships (r = 0.76, 0.73, and 0.81) between the measured and predicted NDVI values of all vegetation in the sub-basin against the groundwater flow (GW), soil water content (SWC), and combination of these two variables, respectively, during the dry season. For the third objective, the SWAT model was simulated against future time series of climate data projections under RCP4.5 and RCP8.5 climate scenarios. The modelling results reveal that vegetation greenness (LAI) decreased by 147.8% during winter and increased by 5.3% in the summer. The MODIS satellite imagery has been proven effective in studying floodplain vegetation at the catchment level, as evidenced by this study. Additionally, the study emphasises how climate change will affect future floodplain vegetation sustainability. The strategic information gathered from this study regarding current and future floodplain vegetation in Australia will be valuable for long-term planning and management of floodplain vegetation in the country.
Differential GPR56 Expression in T Cell Subpopulations for Early-Stage Lung Adenocarcinoma Patient Identification
Creators: name: Ren, Jiaxin
name: Zhu, Yaoyi
name: Nie, Yuying
name: Zheng, Mohan
name: Hasimu, Ainizati
name: Zhao, Ming
name: Zhao, Yiming
name: Ma, Xiancan
name: Yuan, Zihang
name: Li, Qi
name: Bahabayi, Ayibaota
name: Zhang, Zhonghui
name: Zeng, Xingyue
name: Liu, Chen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: This study aimed to investigate the expression of GPR56 in the T cells of early-stage lung adenocarcinoma (LUAD) patients and clarify its diagnostic significance. Blood samples were collected from 32 patients with stage IA LUAD and 31 healthy controls. GPR56 and perforin were analysed in circulating T-cell subsets by flow cytometry. In addition, a correlation between perforin and GPR56 expression was detected. Changes in GPR56+ cells in early LUAD patients were analysed, and the diagnostic significance of GPR56+ T cells for early LUAD was studied by receiver operating characteristic (ROC) curve analysis. The expression of GPR56 in CD8+ T cells from early-stage LUAD patients was significantly greater than that in CD4+ T cells. The percentage of perforin-positive GPR56+ cells in early-stage LUAD patients was high. GPR56 levels in the T cells of LUAD patients were significantly lower than those in healthy controls. ROC analysis revealed that the area under the curve for the percentage of GPR56-positive CD8+ TEMRA cells to distinguish early-stage LUAD patients from healthy individuals- reached 0.7978. The decreased expression of GPR56 in the peripheral blood of early-stage LUAD patients correlated with perforin levels, reflecting compromised antitumor immunity and aiding early-stage LUAD screening.
Tragfähigkeit mechanischer und geklebter Verbindungsmittel in Buchenfurnierschichtholz
Creators: name: Meyer, Nico
Publisher: name: Karlsruhe
Year: 2020
Subjects: Laubholz
Buchenfurnierschichtholz
Verbindungsmittel
Schrauben
eingeklebte Gewindestangen
Fachwerkträger
Fachwerkknoten

description: Buchenfurnierschichtholz (Buchen‐FSH) steht seit 2013 dem Ingenieurholzbau als tragender zugelassener Holzwerkstoff zur Verfügung. Gegenüber dem üblicherweise verwendeten Brettschichtholz aus Nadelholz weist Buchen‐FSH eine dreimal so hohe Zugfestigkeit von ft,0,k = 73 N/mm2 (vgl. ETA‐14/0354) auf. Damit ist Buchen‐FSH der ideale Werkstoff, um weitgespannte und gleichzeitig filigrane Tragwerke aus Holz zu realisieren. Besonders Fachwerkträger stellen für diesen Anwendungszweck eine leistungsfähige, architektonisch ansprechende und ressourcenschonende Konstruktionsvariante dar. Allerdings ist durch die bauaufsichtlichen Regelungen eine materialgerechte Bemessung der notwendigen Verbindungen in Buchen‐FSH bisher nicht möglich. Basierend auf den innerhalb dieser Arbeit durchgeführten experimentellen Untersuchungen wurden jetzt Bemessungs‐ und Konstruktionsgrundlagen für eine wirtschaftliche Dimensionierung der Verbindungen geschaffen. Der Fokus wurde dabei auf axial beanspruchte Schrauben und eingeklebte Gewindestangen gelegt. Bereits bei der Verwendung in Konstruktionen aus Nadelholz zeichnen sich diese durch ihre hohe Tragfähigkeit und Steifigkeit bei gleichzeitig geringen notwendigen Bauteilmaßen aus. Neben der axialen Beanspruchung wurde auch die Tragfähigkeit bei lateraler Beanspruchung untersucht und die zur Bemessung notwendigen Kennwerte für Verbindungen mit Schrauben und Rillennägeln hergeleitet. Die zur Konstruktion notwendigen Verbindungsmittel‐ und Randabstände konnten nicht abschließend ermittelt werden. Weitere Untersuchungen sind notwendig, um ein duktiles Versagen und gleichzeitiges Ausnutzen der ermittelten Tragreserven zu ermöglichen. Zur Verifizierung des Trag‐ und Verformungsverhaltens der untersuchten Verbindungsmittel, auch im Vergleich zu üblicherweise im Holzbau verwendeten Stabdübelverbindungen, wurden Versuche an vollständigen Fachwerkträgern durchgeführt. Insbesondere der Einsatz von eingeklebten Gewindestangen führte zu einer deutlichen Steigerung der Steifigkeit und somit zu einer geringeren Durchbiegung des Gesamtsystems. Aufbauend auf den Trägerversuchen konnte eine neue Prüfmethode zur Ermittlung des Trag‐ und Verformungsverhaltens innerhalb eines Knotens entwickelt werden. Der komplexe Spannungszustand innerhalb der Knotenpunkte kann somit einfacher untersucht und durch eine höhere Anzahl an Prüfkörper wirtschaftlich verifiziert werden.
Sterrhopterix fusca
Creators: name: Volkova, Julia S.
name: Prozorov, Alexey M.
name: Kryuchkov, Sergey N.
name: Pavlov, Pavel O.
name: Yakovlev, Roman V.
name: Anikin, Vasilii V.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Psychidae
Sterrhopterix
Sterrhopterix fusca

description: 21. Sterrhopterix fusca (Haworth, 1829)
(Figs 29, 47)
 Material: ♀, Surskoe District, environs of the village Lava, bilberry-ledum marsh, 54.479973N, 46.901823E, 16.V.2021, S.N. Kryuchkov, Ju.S. Volkova (Fig. 48, site 2); ♂, Surskoe District, environs of the village Lava, bilberry-ledum marsh, 54.479973N, 46.901823E, 7.VI.2019, Ju.S.Volkova, P.O. Pavlov, S.N. Kryuchkov, A.N. Matveev (Fig. 48, site 2).
 Biology. Inhabits forests, meadows and bogs. Polyphagous, found on grass and tree leaves. Adults occur from the end of May until the end of July, active at night and attracted by light.
 Distribution in Russia. Widespread, recorded from the Kaliningrad Oblast to the Primorsky Krai (Sinev & Lovtsova, 2019). In the Volga Region, it is known from Volgograd, Saratov, Samara, and Ulyanovsk Oblasts (Anikin et al. 2017).
description: Published as part of Volkova, Julia S., Prozorov, Alexey M., Kryuchkov, Sergey N., Pavlov, Pavel O., Yakovlev, Roman V. & Anikin, Vasilii V., 2022, Fauna of Psychidae (Lepidoptera) of the Ulyanovsk Oblast (Middle Volga, Russia), pp. 109-121 in Ecologica Montenegrina 58 on page 120, DOI: 10.37828/em.2022.58.10, http://zenodo.org/record/13241156
A Realist Review of Violence Prevention Education in Healthcare
Creators: name: Provost, Sharon
name: MacPhee, Maura
name: Daniels, Michael A.
name: Naimi, Michelle
name: McLeod, Chris B.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Violence from patients and visitors towards healthcare workers is an international concern affecting the safety and health of workers, quality of care, and healthcare system sustainability. Although the predominant intervention has been violence prevention (VP) education for healthcare workers, evaluating its effectiveness is challenging due to underreporting of violence and the inherent complexity of both violence and the health care environment. This review utilized a theory-driven, realist approach to synthesize and analyze a wide range of academic and grey literature to identify explanations of how and why VP education makes a difference in preventing violence and associated physical and psychological injury to workers. The review confirmed the importance of positioning VP education as part of a VP strategy, and consideration of the contexts that influence successful application of VP knowledge and skills. Synthesis and analysis of patterns of evidence across 64 documents resulted in 11 realist explanations of VP education effectiveness. Examples include education specific to clinical settings, unit-level modeling and mentoring support, and support of peers and supervisors during violent incidents. This review informs practical program and policy decisions to enhance VP education effectiveness in healthcare settings.
It's in our lane: a mixed method's evaluation of a firearm injury prevention curriculum for medical students
Creators: name: Martinson, Thomas
name: Kane, Ryan M.
name: Manley, Kelsi
name: Teichman, Rebecca
name: Carney, Patricia A.
name: Burnett, Joel R.
Publisher: name: Oregon Health and Science University
Year: 2024
Subjects: subject: Gun Violence
subject: Education, Medical
subject: Students, Medical
subject: Public Health
subject: Cause of Death
subject: Scope of Practice
subject: Wounds, Gunshot
subject: firearm injury
subject: medical curriculum

description: Firearms are the leading cause of death of U.S. children and young adults. Although physicians believe counseling on firearm injury prevention is within their scope of practice, few routinely counsel patients on firearm injury prevention and most have not received formal education on how to do so. Most medical schools do not teach firearm injury prevention curriculum. To evaluate medical students’ perceived knowledge, confidence, and intention to engage in clinical and policy advocacy approaches to firearm injury prevention following a two-hour, case-based firearm injury prevention curriculum.
3D Printing in Medicine: A New Era for Pharmaceuticals
Creators: name: Mr. Damu Uma Sankar
name: Mr. Gudisi Rama Krishna
name: Dr. B. Kiran Kumar
name: Ms. Jagarapu Aruna
name: Ms. Kosuru Lakshmi Gayatri
name: Mr. Kuna Akash
name: Mr. Mylapalli Ajay Kumar
name: Mr. Mallapureddi Venu Babu
name: Mr. Pinniti Vamsi Krishna
name: Ms. Gunana Supriya
name: Mrs. Gurana Radha
name: Ms. Kondabattula Hema Sri
name: Ms. Jami Bhargavi
name: Ms.  Koppala Bhavani
name: Mr. Manchipalli Jeswanth
Publisher: name: Institute for Interdisciplinary and Venture Publication
Year: 2025
Subjects: 3D Printing
Pharmaceutical formulation
pharmaceutical market

description: The introduction of three-dimensional (3D) printing technology in the pharmaceutical industry is poised to revolutionize the field, enabling personalized treatments tailored to individual patients' specific needs, including age, weight, and genetic characteristics. This innovative technology allows for the creation of complex dosage forms, such as microcapsules and multilayered drug delivery devices, using various printing methods like inkjet, fused deposition modeling, and hot melt extrusion. With its widespread applications in pharmaceuticals, from lab-grown organs to personalized medicines, 3D printing is emerging as a valuable, efficient, and economical tool that has the potential to transform the future of pharmacy practice and pharmaceutical care.
title: Carbon capture and utilisation in the cement industry: A technological and economical assessment of carbon capture and electrolysis technologies and its implications on energy demand
Creators: name: Eiler, Peter
Publisher: name: TU Wien
Year: 2022
Subjects: subject: cement
subject: decarbonisation
subject: carbon capture and utilization (CCU)
subject: electrolysis

description: To reduce global warming, the reduction of greenhouse gas emissions is crucial. Inmany cases, this cannot be achieved directly through the substitution of fossil fuelsby renewable energy sources. Carbon capture and utilization projects can provide aviable solution, in particular for the cement industry, where carbon dioxide emissionsare immanent to the production process of clinker.The objective of this master thesis is to investigate and discuss the carbon captureand hydrogen production technology, as proposed by the carbon capture andutilization demonstration project ‘Carbon-to-product-Austria’. To achieve this, the cement production as well as carbon capture and hydrogen production technologies will be evaluated in order to derive technological and economic implications for the potential implementation in the entire cement industry in Austria. Furthermore, the electricity demand for the production of renewable hydrogen via water electrolysis will be calculated to allow a comparison with the current national renewable energy strategy in Austria.The existing research projects support the technology choices made in this demonstration project, as mono ethanolamine-based amine scrubbing is the onlycarbon capture technology available, that provides a sufficient technological maturityto be applied in an industrial scale demonstration project. However, existing alternative technologies provide viable alternatives, especially from an economic perspective, once the technological maturity is further progressed. The available hydrogen production technologies via water electrolysis also differ in their respective technological maturity, but can provide viable applications, depending on the respective production requirements and locally available electricity and heat sources.The energy required for the renewable hydrogen demand of such carbon capture and utilization pathways cannot be covered by the existing renewable energy targets forthe year 2030 as stated by the current Austrian climate and energy strategy.Therefore, an evaluation of a potential increase of the renewable energy targets and further renewable energy development in Austria need to be considered, or alternatively ways to import the renewable hydrogen from suitable geographies need to be discovered.
Resurrection of a Viral Internal Ribosome Entry Site from a 700 Year Old Ancient Northwest Territories Cripavirus
Creators: name: Wang, Xinying
name: Vlok, Marli
name: Flibotte, Stephane
name: Jan, Eric
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented, streamlined mechanism whereby the IRES adopts a triple-pseudoknot (PK) structure to directly bind to the conserved core of the ribosome and drive translation from a non-AUG codon. The origin of this IRES mechanism is not known. Previously, a partial fragment of a divergent dicistrovirus RNA genome, named ancient Northwest territories cripavirus (aNCV), was extracted from 700-year-old caribou feces trapped in a subarctic ice patch. The aNCV IGR sequence adopts a secondary structure similar to contemporary IGR IRES structures, however, there are subtle differences including 105 nucleotides upstream of the IRES of unknown function. Using filter binding assays, we showed that the aNCV IRES could bind to purified ribosomes, and toeprinting analysis pinpointed the start site at a GCU alanine codon adjacent to PKI. Using a bicistronic reporter RNA, the aNCV IGR can direct translation in vitro in a PKI-dependent manner. Lastly, a chimeric infectious clone swapping in the aNCV IRES supported translation and virus infection. The characterization and resurrection of a functional IGR IRES from a divergent 700-year-old virus provides a historical framework for the importance of this viral translational mechanism.
Leitfaden zur Vermeidung von Lebensmittelabfällen beim Catering
Creators: name: Fink, Leonie
name: Roehl, Rainer
name: Strassner, Carola
Publisher: name: My University
Year: 2016
Subjects: subject: Nahrungsmittelabfall
subject: Nahrungsmittelverschwendung
subject: Gastronomie
subject: Lebensmittelabfall
subject: Lebensmittelabfälle
subject: Lebensmittelverschwendung
subject: Lebensmittelvergeudung
subject: Lebensmittelverluste
subject: catering
subject: Abfall | Ressourcen

description: Lebensmittel haben einen bedeutenden ökologischen Rucksack. Ihre Erzeugung benötigt Fläche, verbraucht Wasser und emittiert Treibhausgase. Leider entstehen allein in Deutschland pro Jahr rund 6,7 Millionen Tonnen Lebensmittelabfälle in den privaten Haushalten. Etwa ein Drittel aller im Außer-Haus-Verzehr hergestellten Speisen landen im Abfall. Wie sich Lebensmittelabfälle beim Catering vermeiden lassen – ob auf Tagungen und Messen, privaten Feiern oder Firmenjubiläen – erläutert dieser Leitfaden mit praktikablen und einfach umsetzbaren Tipps.