cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Homological algebra modulo exact zero-divisors
Creators: name: Bergh, Petter Andreas
name: Celikbas, Olgur
name: Jorgensen, David A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13D03

description: We study the homological behavior of modules over local rings modulo exact zero-divisors. We obtain new results which are in some sense "opposite" to those known for modules over local rings modulo regular elements.
description: Revised and final version, 14 pages. To appear in Kyoto J. Math
The symplectic Deligne-Mumford stack associated to a stacky polytope
Creators: name: Sakai, Hironori
Publisher: name: arXiv
Year: 2010
Subjects: subject: Symplectic Geometry (math.SG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 57R18, 53D99

description: We discuss a symplectic counterpart of the theory of stacky fans. First, we define a stacky polytope and construct the symplectic Deligne-Mumford stack associated to the stacky polytope. Then we establish a relation between stacky polytopes and stacky fans: the stack associated to a stacky polytope is equivalent to the stack associated to a stacky fan if the stacky fan corresponds to the stacky polytope.
description: 20 pages; v2: To appear in Results in Mathematics
Experimental demonstration of coherent feedback control on optical field squeezing
Creators: name: Iida, Sanae
name: Yukawa, Mitsuyoshi
name: Yonezawa, Hidehiro
name: Yamamoto, Naoki
name: Furusawa, Akira
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Coherent feedback is a non-measurement based, hence a back-action free, method of control for quantum systems. A typical application of this control scheme is squeezing enhancement, a purely non-classical effect in quantum optics. In this paper we report its first experimental demonstration that well agrees with the theory taking into account time delays and losses in the coherent feedback loop. The results clarify both the benefit and the limitation of coherent feedback control in a practical situation.
description: 7 pages
Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease
Creators: name: Leypoldt, F.
name: Buchert, R.
name: Kleiter, I.
name: Marienhagen, Jörg
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: 610 Medizin

description: Background: Patients with encephalitis associated with antibodies against N-methyl-D-aspartate-receptor antibody (NMDAR-ab) encephalitis frequently show psychotic symptoms, amnesia, seizures and movement disorders. While brain MRI in NMDAR-ab encephalitis is often normal, abnormalities of cerebral glucose metabolism have been demonstrated by positron emission tomography (PET) with 18F-fluorodeoxyglucose(FDG) in a few usually isolated case reports. However, a common pattern of FDG-PET abnormalities has not been reported. Methods: The authors retrospectively identified six patients with NMDAR-ab encephalitis in two large German centres who underwent at least one whole-body FDG-PET for tumour screening between January 2007 and July 2010. They analysed the pattern of cerebral uptake derived from whole-body PET data for characteristic changes of glucose metabolism compared with controls, and the changes of this pattern during the course of the disease. Results: Groupwise analysis revealed that patients with NMDAR-ab encephalitis showed relative frontal and temporal glucose hypermetabolism associated with occipital hypometabolism. Cross-sectional analysis of the group demonstrated that the extent of these changes is positively associated with clinical disease severity. Longitudinal analysis of two cases showed normalisation of the pattern of cerebral glucose metabolism with recovery. Conclusions: A characteristic change in cerebral glucose metabolism during NMDAR-ab encephalitis is an increased frontotemporal-to-occipital gradient. This pattern correlates with disease severity. Similar changes have been observed in psychosis induced by NMDAR antagonists. Thus, this pattern might be a consequence of impaired NMDAR function.
Gendered sexualities in migration : play, pageantry, and the politics of performing Filipino-ness in settler colonial Canada
Creators: name: Farrales, May Leanne
Publisher: name: University of British Columbia
Year: 2017

description: This dissertation examines the sexualities of Filipino/as in Canada who live and work on the traditional and ancestral territories of the Musqueam, Skxwú7mesh, and Tsleil-Waututh peoples (Vancouver). Specifically, it sketches out how gender and sexual paradigms in the Philippines are brought to Canada through labour migration and are re-scripted in relation to racial, gender and sexual regimes in Canada. I examine how these negotiations take shape at three particular sites and community-organized spaces. The first site in which I attend to the making of sexualities is at Filipino basketball leagues and games organized in the local community. The second site is at community-organized beauty and religious pageants. And finally, I consider how sexualities are being articulated and worked with by self-identifying Filipino/a queer, lesbian, gay and transgender organizers and activists. I work with interviews and observations I collected at each of these community-organized spaces. To analyze how sexualities are negotiated at these sites, I use a queer diaspora, queer of colour and transnational framework that attempts to be mindful of Indigenous critiques that urge for scholarship to take into account the ongoing processes of colonialism in settler colonial nations like Canada. The dissertation suggests that sexualities taking shape at basketball games, beauty pageants and in Filipino/a queer spaces are influenced by dominant racial, gender and sexual paradigms formed in the Philippines' colonial encounters at the same time as they are negotiated in relation to normative white heteropatriarchal settler colonial logics in Canada. More broadly I argue that the racialized, classed and gendered sexualities of Filipino/as are being made and remade in the overlapping colonial and capitalist geographies of Canada's and the Philippines' distinct nation-building projects. I suggest that engaging with these geographies poses critical questions of place and politics for Filipina/os in Canada by offering ways of understanding nation that might wear away at the normalizing logics.
Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis
Creators: name: van der Goes, M. C.
name: Straub, Rainer H.
name: Wenting, M. J. G.
name: Capellino, Silvia
name: Rauch, Luise
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: 610 Medizin

description: Objectives: To explore changes in the number of steroid hormone receptor positive cells in synovial tissue (ST) after intra-articular glucocorticoid injection, to correlate these changes with changes in clinical variables, and to evaluate whether the number of steroid hormone receptor positive cells predicted the clinical response to glucocorticoid injection. Methods: Fourteen patients with persistent knee arthritis despite at least two previous injections in an outpatient setting received an intra-articular injection with glucocorticoids, followed by 3 days of admission with bed rest. Clinical efficacy was assessed at 6 and 12 weeks. ST biopsies were performed 2 weeks before and 12 weeks after the injection. The presence of different cell types (T cells, macrophages, fibroblast-like synoviocytes) and numbers of glucocorticoid, androgen and oestrogen α and β receptor positive cells were evaluated by histochemistry. Results: Patients showed, despite previous failures, good clinical response to glucocorticoid injection, with significant improvement in erythrocyte sedimentation rate, visual analogue scale (VAS) for pain, and joint disability score. The number of steroid hormone receptor positive cells decreased markedly (p<0.05 for all four receptors). The decrease in oestrogen receptor α positive cells correlated significantly with the improvement in VAS for pain and joint disability score. The number of glucocorticoid, androgen and oestrogen α and β receptor positive cells before injection did not predict the effect of treatment. Conclusions: Intra-articular glucocorticoid injections followed by bed rest for persistent arthritis are clinically effective and significantly decrease the number of steroid hormone receptor positive cells in ST. The relevance of the latter needs further study.
Additional file 2 of DREAMS: deep read-level error model for sequencing data applied to low-frequency variant calling and circulating tumor DNA detection
Creators: name: Christensen, Mikkel H.
name: Drue, Simon O.
name: Rasmussen, Mads H.
name: Frydendahl, Amanda
name: Lyskjær, Iben
name: Demuth, Christina
name: Nors, Jesper
name: Gotschalck, Kåre A.
name: Iversen, Lene H.
name: Andersen, Claus L.
name: Pedersen, Jakob Skou
Publisher: name: figshare
Year: 2023
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 2. Review history.
The effects of midazolam on intraocular pressure in children during examination under sedation
Creators: name: Oberacher-Velten, Isabel
name: Prasser, Christopher
name: Rochon, Justine
name: Ittner, Karl-Peter
name: Helbig, Horst
name: Lorenz, Birgit
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 610 Medizin

description: Background: To obtain reliable and accurate measurements of the intraocular pressure (IOP) in children often requires sedation or anaesthesia. Therefore, we investigated the effects of oral midazolam on IOP in children. Methods: In a prospective study, IOP was measured in 72 eyes of 36 cooperative children without glaucoma requiring general anaesthesia (mean age 3.5±1.3 years, body weight ≤20 kg) by using a Perkins hand-held tonometer. Measurements of IOP were performed before, and 15 and 30 min after sedation with orally administered midazolam (1 mg/kg) given as preoperative medication, and 5 and 15 min after induction of general anaesthesia. The individual IOP courses were analysed. Results: In all of the cooperative children, IOP measurement was possible after sedation with midazolam. Mean IOP was 11.2±0.3 mmHg before sedation, 10.9±0.2 mmHg at 15 min, and 10.7±0.3 mmHg 30 min after administration of midazolam. This small decrease was not statistically significant, whilst the IOP decline at 5 and 15 min after induction of general anaesthesia was statistically significant (p<0.0001). Conclusion: Sedation with midazolam can be assumed to be an applicable, well-tolerated, safe method for IOP measurements in children.
SLE curves and natural parametrization
Creators: name: Lawler, Gregory F.
name: Zhou, Wang
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: Developing the theory of two-sided radial and chordal $\mathit{SLE}$, we prove that the natural parametrization on $\mathit{SLE}_κ$ curves is well defined for all $κ<8$. Our proof uses a two-interior-point local martingale.
description: Published in at http://dx.doi.org/10.1214/12-AOP742 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Keratinocytic epidermal nevi are associated with mosaic RAS mutations
Creators: name: Hafner, Christian
name: Toll, Agustí
name: Gantner, Susanne
name: Mauerer, Andreas
name: Dietmaier, Wolfgang
name: Landthaler, Michael
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: 610 Medizin

description: Background: Activating RAS mutations in the germline cause rare developmental disorders such as Costello syndrome. Somatic RAS mutations are found in approximately 30% of human cancers. Keratinocytic epidermal nevi (KEN) represent benign congenital skin lesions arranged along Blaschko's lines. A subgroup of KEN is caused by hotspot oncogenic FGFR3 and PIK3CA mutations in mosaicism, but the majority lack these mutations. Methods: This study screened 72 KEN for activating mutations in RAS genes and other oncogenes. Results: Activating RAS mutations were identified in 28/72 (39%) of KEN. HRAS was the most commonly affected oncogene (86%), with the HRAS p.G13R substitution representing a new hotspot mutation. Conclusion: These results indicate that activating RAS somatic mutations leading to mosaicism result in benign KEN of the skin. Given the prevalence of KEN, mosaic HRAS mutations appear to be more common in patients than germline ones. These findings identify KEN as a mosaic RASopathy and lend further support to the notion that genetic mosaicism is an important contributor to disease.
A comparison of three supraglottic airway devices used by healthcare professionals during paediatric resuscitation simulation
Creators: name: Schunk, Domagoj
name: Ritzka, Markus
name: Graf, Bernhard
name: Trabold, Benedikt
Publisher: name: Universität Regensburg
Year: 2013
Subjects: subject: 610 Medizin

description: Objective: The aim of this study was to determine the best airway device among the laryngeal mask, I-gel and the laryngeal tube used by healthcare professional groups with different levels of experience with paediatric airway management. Method: Three groups of healthcare professionals were separately provided with brief supervised training in using the three devices. Afterwards the participants were asked to place the airway device. For every participant, the positioning of each device was recorded. The success rate and timing of insertion were measured. Furthermore, each insertion was scored for the ease of insertion, clinical and fibreoptic verification of the position and successful ventilation. Results: A total of 66 healthcare providers (22 paramedics, 22 nurse anaesthetists and 22 anaesthesia residents) participated in the study. The median time of insertion of both the laryngeal mask and the tube was significantly longer than for the I-gel for all professional groups (p<0.001). The success rate with the I-gel was higher than that with the laryngeal mask or tube (p<0.001). Except for the laryngeal mask, there were no differences among the professional groups regarding the fibreoptic evaluation. Conclusions: In terms of both the time required for successful placement and the rate of successful placement, the I-gel is superior to the laryngeal mask and tube in paediatric resuscitation simulations by healthcare professional groups with different levels of experience with paediatric airway management.
ARDC Training Materials Metadata Checklist v1.1
Creators: name: Martinez, Paula Andrea
name: Unsworth, Kathryn
Publisher: name: Zenodo
Year: 2021
Subjects: checklist
Training material
FAIR
standard
requirements
metadata

description: The ARDC Training Materials Metadata Checklist aims to support learning designers, training materials creators, trainers and national training infrastructure providers to capture key information and apply appropriate mechanisms to enable sharing and reuse of their training materials
description: The ARDC is a transformational initiative that enables Australian research community and industry access to nationally significant, leading edge data intensive eInfrastructure, platforms, skills and collections of high-quality data. The purpose of the ARDC is to provide Australian researchers with competitive advantage through data, providing access to leading edge eResearch collections, tools, infrastructure and services. Its mission is to accelerate research and innovation by driving excellence in the creation, analysis and retention of high-quality data assets.
description: {"references": ["Garcia et al. (2020). Ten simple rules for making training materials FAIR. https://doi.org/10.1371/journal.pcbi.1007854"]}
Additional file 2 of Bacillus spp. isolated from pepper leaves and their function and inhibition of the fungal plant pathogen Colletotrichum scovillei
Creators: name: Wei, Lijuan
name: Yang, Chengde
name: Cui, Lingxiao
name: Jin, Mengjun
name: Osei, Richard
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 2: Table S1. First screening of antagonistic ability of endophytic strains against C. scovillei.
The fundamental group as a topological group
Creators: name: Brazas, Jeremy
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Topology (math.AT)
subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 14H30, 14F35, 54H11,

description: This paper is devoted to the study of a natural group topology on the fundamental group which remembers local properties of spaces forgotten by covering space theory and weak homotopy type. It is known that viewing the fundamental group as the quotient of the loop space often fails to result in a topological group; we use free topological groups to construct a topology which promotes the fundamental group of any space to topological group structure. The resulting invariant, denoted $π_{1}^τ$, takes values in the category of topological groups, can distinguish spaces with isomorphic fundamental groups, and agrees with the quotient fundamental group precisely when the quotient topology yields a topological group. Most importantly, this choice of topology allows us to naturally realize free topological groups and pushouts of topological groups as fundamental groups via topological analogues of classical results in algebraic topology.
description: 23 pages
Systematic Continuum Errors in the Lyman-Alpha Forest and The Measured Temperature-Density Relation
Creators: name: Lee, Khee-Gan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Continuum fitting uncertainties are a major source of error in estimates of the temperature-density relation (usually parametrized as a power-law, $T \propto Δ^{γ- 1} $) of the inter-galactic medium (IGM) through the flux probability distribution function (PDF) of the Lyman-$α$ forest. Using a simple order-of-magnitude calculation, we show that few percent-level systematic errors in the placement of the quasar continuum due to e.g. a uniform low-absorption Gunn-Peterson component, could lead to errors in $γ$ of order unity. This is quantified further using a simple semi-analytic model of the Lya forest flux PDF. We find that under-(over-)estimates in the continuum level can lead to a lower (higher) measured value of $γ$. Within current observational uncertainties, continuum biases double the error in $γ$ from $σ_γ \approx 0.1$ to $σ_γ \approx 0.2$ within our model. We argue that steps need to be taken to directly estimate the level of continuum bias in order to make recent claims of an inverted \tdr\ more robust.
description: 8 pages, 8 figures. Accepted by ApJ
Revisiting the $B^{(*)}_s$-Meson Production at the Hadronic Colliders
Creators: name: Zhang, Jia-Wei
name: Chen, Xue-Wen
name: Jiang, Jun
name: Sun, Zhan
name: Wu, Xing-Gang
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The production of heavy-flavored hadron at the hadronic colliders provides a challenging opportunity to test the validity of pQCD predictions. There are two mechanisms for the $B^{(*)}_s$ hadroproduction, i.e. the gluon-gluon fusion mechanism via the subprocess $g+g\rightarrow B^{(*)}_s+b+\bar{s}$ and the extrinsic heavy quark mechanism via the subprocesses $g+\bar{b}\to B^{(*)}_s +\bar{s}$ and $g+s\to B^{(*)}_s +b$, both of which shall have sizable contributions in proper kinematic region. Different from the fixed-flavor-number scheme (FFNS) previously adopted in the literature, we study the $B^{(*)}_s$ hadroproduction under the general-mass variable-flavor-number scheme (GM-VFNS), in which we can consistently deal with the double counting problem from the above two mechanisms. Properties for the $B^{(*)}_s$ hadroproduction are discussed. To be useful reference, a comparative study of FFNS and GM-VFNS is presented. Both of which can provide reasonable estimations for the $B^{(*)}_s$ hadroproduction. At the Tevatron, the difference between these two schemes is small, however such difference is obvious at the LHC. The forthcoming more precise data on LHC shall provide a good chance to check which scheme is more appropriate to deal with the $B^{(*)}_s$-meson production and to further study the heavy quark components in hadrons.
description: 18 pages, 8 figures, 4 tables. To match the published version. To be published in Eur.Phys.J.C
Additional file 1 of Bacillus spp. isolated from pepper leaves and their function and inhibition of the fungal plant pathogen Colletotrichum scovillei
Creators: name: Wei, Lijuan
name: Yang, Chengde
name: Cui, Lingxiao
name: Jin, Mengjun
name: Osei, Richard
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1: Fig. S1. Standard curve of IAA based on two colorimetric solutions PC and S2.
Training resources for sharing and reuse
Creators: name: Martinez, Paula Andrea
Publisher: name: Zenodo
Year: 2021
Subjects: FAIR training material
training material
guides
software citation
software publishing
containers
software licensing
training materials checklist
research data governance

description: This presentation outlines the work completed during a consultancy for ARDC by Dr Paula Martinez to develop new and publish existing national skills materials for reuse by the sector. She was responsible for the work package targeted to co-develop national skills materials with a strong emphasis on sharing and reuse. This was a very collaborative project with the opportunity to work with different target audiences, topics and support expertise. To accommodate for a short timeline. We defined the scope to six topics. 1) Containers in Research 2) Data Governance 3) Software citation and Licensing 4) FAIR Data 101 5) Metadata for Training Materials 6) Machine Learning Resources. You can watch the video on YouTube here: https://youtu.be/10Yv_BFa-mw
description: The ARDC is a transformational initiative that enables Australian research community and industry access to nationally significant, leading edge data intensive eInfrastructure, platforms, skills and collections of high-quality data. The purpose of the ARDC is to provide Australian researchers with competitive advantage through data, providing access to leading edge eResearch collections, tools, infrastructure and services. Its mission is to accelerate research and innovation by driving excellence in the creation, analysis and retention of high-quality data assets. Speaker bio: Paula Andrea Martinez is currently the Software Project Coordinator at ARDC. Her work supports the new ARDC Software Program for Australia leading to better research software recognition. She is a former ARDC consultant whose work focused on development of National Training Materials in various selected topics. She is also an advocate of Open Science, better research, diversity and community projects like the FAIR4RS, The Carpentries, ROpenSci and R-Ladies. She is also working with the Research Software Alliance as part time Community Manager.
Higher Spin Theories in AdS_3 and a Gravitational Exclusion Principle
Creators: name: Castro, Alejandra
name: Lepage-Jutier, Arnaud
name: Maloney, Alexander
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider theories of three dimensional quantum gravity in Anti-de Sitter space which possess massless higher-spin gauge symmetry. The perturbative spectrum of the theory includes higher spin excitations which can be organized into vacuum representations of the W_N algebra; these are higher spin versions of the boundary gravitons. We describe a fundamental bound which relates the value of the cosmological constant to the amount of gauge symmetry present. In the dual CFT language, this is the statement that modular invariance implies that the theory can not be quantized unless the central charge is sufficiently large, i.e. if c is greater than or equal to N-1. This bound relies on the assumption that all of the perturbative excitations exist as full states in the quantum theory, and can be circumvented if the theory possesses a linearization instability. The W_N minimal models -- recently conjectured to be dual to certain higher spin AdS theories by Gaberdiel and Gopakumar - provide an example of this phenomenon. This result can be regarded as an example of a "gravitational exclusion principle" in Anti-de Sitter space, where a non-perturbative quantum gravity mechanism involving black holes places a limit on the number of light degrees of freedom present.
description: 21 pages, 2 figures; v2, typos fixed
Additional file 3 of Bacillus spp. isolated from pepper leaves and their function and inhibition of the fungal plant pathogen Colletotrichum scovillei
Creators: name: Wei, Lijuan
name: Yang, Chengde
name: Cui, Lingxiao
name: Jin, Mengjun
name: Osei, Richard
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 3: Table S2. Retest of endophytic strains with excellent antagonism to C. scovillei.
The LaLiMo Trial: lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsy—an open-label, prospective, randomised controlled multicenter study
Creators: name: Rosenow, F.
name: Schade-Brittinger, C.
name: Burchardi, N.
name: Arnold, Stephan
name: LaLiMo Study Group,
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: 610 Medizin

description: Background: Of the newer antiepileptic drugs, lamotrigine (LTG) and levetiracetam (LEV) are popular first choice drugs for epilepsy. The authors compared these drugs with regard to their efficacy and tolerability in the initial monotherapy for epilepsy. Methods: A randomised, open-label, controlled, parallel group, multicenter trial was conducted to test the superiority of the LEV arm over the LTG arm. The primary endpoint was the rate of seizure-free patients in the first 6 weeks (two-sided Fisher's exact test, α=0.05, intent-to-treat set). Furthermore, efficacy, tolerability and quality of life were evaluated. The authors included 409 patients aged ≥12 years with newly diagnosed focal or generalised epilepsy defined by either two or more unprovoked seizures or one first seizure with high risk for recurrence. Patients were titrated to 2000 mg/day of LEV or 200 mg/day of LTG reached on day 22 or 71, respectively. Two dose adjustments by 500/50 mg were allowed. Results: The proportions of seizure-free patients were 67.5% (LEV) versus 64.0% (LTG) 6 weeks after randomisation (p=0.47), and 45.2% (LEV) versus 47.8% (LTG) during the whole treatment period of 26 weeks. The HR (LEV vs LTG) for seizure-free time was 0.86 (95% CI, 0.61 to 1.22). Adverse events occurred in 74.5% (LEV) versus 70.6% (LTG) of the patients (p=0.38). Adverse events associated with study discontinuation occurred in 17/204 (LEV) versus 8/201 (LTG) patients (p=0.07). Conclusions: There were no significant differences with regard to efficacy and tolerability of LEV and LTG in newly diagnosed focal and generalised epilepsy despite more rapid titration in the LEV arm. Clinical trial registration number: ClinicalTrials.gov identifier NCT00242606.
Novel automated approach to the quantitative analysis of dopaminergic functional images in a large cohort of Parkinson's patients
Creators: name: Shenkov, Nikolay
Publisher: name: University of British Columbia
Year: 2017

description: PET and SPECT are nuclear medicine imaging techniques that allow for the study of physiological processes in vivo. These techniques allow to assess the dopaminergic system in subjects with Parkinson's disease (PD), which is the system most severely affected by the disease. Parkinson’s Progression Markers Initiative is a multicenter, longitudinal study aimed at identifying novel biomarkers of PD progression. This study utilizes brain SPECT/PET imaging to investigate the dopaminergic system, by examining the distribution of the dopamine transporter (DaT) or the vesicular monoamine transporter 2 (VMAT) in the striatum. Several imaging metrics can be used to quantify the dopaminergic tracer binding in the striatum. These metrics are typically calculated on regions of interest (ROIs) that require either manual placement or coregistration with MR structural images. In the first part of this work, an automated approach to quantifying dopaminergic tracer binding is presented; the method consists of a new metric, SI, evaluated over a bounding box that is automatically placed on the SPECT/PET images. In order to validate this metric, the correlation is computed between the SI values and the motor scores of PD subjects from the PPMI database. We find that sum intensity achieves correlations as strong as the ones obtained using conventional approaches such as the putamen binding ratio, evaluated on manually-placed ROIs, but using a simplified and operator-independent approach. The second part of this work focuses on predicting the rate of PD progression over the four years during which the PD subjects were enrolled in the PPMI study. Two methods of quantifying disease progression are considered. The first approach uses imaging features collected at year-0 of the study to predict the decline in the putamen binding ratios over the next four years. The model achieves a prediction error of 13% for the better side of the putamen, which is comparable to the test-retest reproducibility of this metric. The second approach uses imaging and clinical features at year-0 to predict the clinical outcome (quantified by year-4 motor and cognitive scores). Novel combinations of clinical and imaging features that are predictors of disease severity are identified.
Additional file 1 of Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
Creators: name: Fiedler, Timon
name: Fairless, Richard
name: Pichi, Kira
name: Fischer, Roman
name: Richter, Fabian
name: Kontermann, Roland E.
name: Pfizenmaier, Klaus
name: Diem, Ricarda
name: Williams, Sarah K.
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Fig. S1. Flow cytometry gating strategy.
A density version of the Halpern-Läuchli theorem
Creators: name: Dodos, Pandelis
name: Kanellopoulos, Vassilis
name: Karagiannis, Nikolaos
Publisher: name: arXiv
Year: 2010
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We prove a density version of the Halpern-Läuchli Theorem. This settles in the affirmative a conjecture of R. Laver. Specifically, let us say that a tree $T$ is homogeneous if $T$ has a unique root and there exists an integer $b\meg 2$ such that every $t\in T$ has exactly $b$ immediate successors. We show that for every $d\meg 1$ and every tuple $(T_1,...,T_d)$ of homogeneous trees, if $D$ is a subset of the level product of $(T_1,...,T_d)$ satisfying \[ \limsup_{n\to\infty} \frac{|D\cap \big(T_1(n)\times ... \times T_d(n)\big)|}{|T_1(n)\times ... \times T_d(n)|}>0\] then there exist strong subtrees $(S_1, ..., S_d)$ of $(T_1,...,T_d)$ having common level set such that the level product of $(S_1,...,S_d)$ is a subset of $D$.
description: 27 pages, no figures; Advances in Mathematics, to appear
title: Формирование концепции Центра ивуарийской культуры в городе Абиджан, Кот-д’Ивуар
Creators: name: Ричмонд, Ачи Ачи Намонго
name: Кузьменко, Светлана
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: В статье рассматривается влияние идентичности народа на формирование архитектурного объекта на примере культурного центра, который становится векторным инструментом влияния на городскую среду. Принимаются во внимание факторы окружающей среды и культурные коды национальной идентичности. Раскрывается и
используется в основе задания на проектирование неотъемлемая взаимосвязь между национальной культурой, технологией общественного здания, городским общественным пространством с применением новейших технологий и инструментов возведения подобных объектов в странах с жарким климатом, с помощью которых выражение культуры будет иметь большее влияние.
Additional file 2 of Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
Creators: name: Fiedler, Timon
name: Fairless, Richard
name: Pichi, Kira
name: Fischer, Roman
name: Richter, Fabian
name: Kontermann, Roland E.
name: Pfizenmaier, Klaus
name: Diem, Ricarda
name: Williams, Sarah K.
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Fig. S2. Full uncropped Western blot images.
Skills training & materials - developing sharing guidelines and agreements
Creators: name: Crowe, Mark
name: Papaioannou, Anastasios
Publisher: name: Zenodo
Year: 2020
Subjects: training material
training
sharing guidelines
sharing agreements

description: Anyone who has developed training content - specifically hands-on, short format, data science training - will know that it is expensive and time consuming. As a rule of thumb, one can expect to spend 15-20 hours of development time per hour of delivery time. Even once the main work is done, there are still ongoing maintenance demands, from correcting the inevitable typos and adapting to software version updates, to major rewrites as best practice techniques evolve. Few Australians training organisations have a funding mandate for developing training material for general use. Instead most of us build training for our own communities in response to demand from those communities, allocating our limited resources to the areas of perceived highest demand. Notwithstanding this local focus, most training organisations operate in similar research environments with similar community demands, so there are real opportunities for benefit from collaboration between those organisations. In this session we will discuss how such collaboration could occur and whether a standardised national agreement around sharing of training material is an achievable outcome. This session will not discuss co-delivery opportunities, institution-specific content such as HPC training and data management, or consolidation of existing similar workshops into a single course. These are important topics, but we don’t have time to do them justice today.
TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals
Creators: name: Stöhr, H.
name: Heisig, J. B.
name: Benz, P. M.
name: Schöberl, S.
name: Milenkovic, V. M.
name: Strauss, O.
name: Aartsen, W.
name: Wijnholds, J.
name: Weber, Bernhard H. F.
name: Schulz, H. L.
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 610 Medizin

description: Photoreceptor ribbon synapses release glutamate in response to graded changes in membrane potential evoked by vast, logarithmically scalable light intensities. Neurotransmitter release is modulated by intracellular calcium levels. Large Ca2+-dependent chloride currents are important regulators of synaptic transmission from photoreceptors to second-order neurons; the molecular basis underlying these currents is unclear. We cloned human and mouse TMEM16B, a member of the TMEM16 family of transmembrane proteins, and show that it is abundantly present in the photoreceptor synaptic terminals in mouse retina. TMEM16B colocalizes with adaptor proteins PSD95, VELI3, and MPP4 at the ribbon synapses and contains a consensus PDZ class I binding motif capable of interacting with PDZ domains of PSD95. Furthermore, TMEM16B is lost from photoreceptor membranes of MPP4-deficient mice. This suggests that TMEM16B is a novel component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. TMEM16B confers Ca2+-dependent chloride currents when overexpressed in mammalian cells as measured by halide sensitive fluorescent protein assays and whole-cell patch-clamp recordings. The compartmentalized localization and the electrophysiological properties suggest TMEM16B to be a strong candidate for the long sought-after Ca2+-dependent chloride channel in the photoreceptor synapse.
Accessible Capacity of Secondary Users
Creators: name: Huang, Xiujie
name: Ma, Xiao
name: Lin, Lei
name: Bai, Baoming
Publisher: name: arXiv
Year: 2010
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: A new problem formulation is presented for the Gaussian interference channels (GIFC) with two pairs of users, which are distinguished as primary users and secondary users, respectively. The primary users employ a pair of encoder and decoder that were originally designed to satisfy a given error performance requirement under the assumption that no interference exists from other users. In the scenario when the secondary users attempt to access the same medium, we are interested in the maximum transmission rate (defined as {\em accessible capacity}) at which secondary users can communicate reliably without affecting the error performance requirement by the primary users under the constraint that the primary encoder (not the decoder) is kept unchanged. By modeling the primary encoder as a generalized trellis code (GTC), we are then able to treat the secondary link and the cross link from the secondary transmitter to the primary receiver as finite state channels (FSCs). Based on this, upper and lower bounds on the accessible capacity are derived. The impact of the error performance requirement by the primary users on the accessible capacity is analyzed by using the concept of interference margin. In the case of non-trivial interference margin, the secondary message is split into common and private parts and then encoded by superposition coding, which delivers a lower bound on the accessible capacity. For some special cases, these bounds can be computed numerically by using the BCJR algorithm. Numerical results are also provided to gain insight into the impacts of the GTC and the error performance requirement on the accessible capacity.
description: 42 pages, 12 figures, 2 tables; Submitted to IEEE Transactions on Information Theory on December, 2010, Revised on November, 2013
Photochromic Coenzyme Q Derivatives: Switching Redox Potentials with Light
Creators: name: Simeth, Nadja Anita
name: Kneuttinger, Andrea C.
name: Sterner, Reinhard
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: Photoswitch, Photochromic compound, Photochromism, Photopharmacology, Redox potential, Coenzyme Q
subject: 540 Chemie

description: Coenzyme Q is an important redox cofactor involved in a variety of cellular processes, and thus found in several cell compartments. We report a photochromic derivative of coenzyme Q that combines the molecular structures of the redox active cofactor and a photochromic dye. Light irradiation triggers an electronic rearrangement reversibly changing the redox potential. We used this effect to control the intermolecular redox reaction of the photochromic coenzyme Q derivative with dihydropyridine in solution by light irradiation. On mitochondria, the altered redox properties showed an effect on the respiratory chain. The experiments demonstrate that the redox reactions can be initiated inside the system of interest through irradiation with light and the accompanied photoisomerization.
Statistical Properties of Thermal Sunyaev-Zel'dovich Maps
Creators: name: Munshi, Dipak
name: Joudaki, Shahab
name: Smidt, Joseph
name: Coles, Peter
name: Kay, Scott T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: At high angular frequencies, beyond the damping tail of the primary power spectrum, the dominant contribution to the power spectrum of cosmic microwave background (CMB) temperature fluctuations is the thermal Sunyaev-Zel'dovich (tSZ) effect. We investigate various important statistical properties of the Sunyaev-Zel'dovich maps, using well-motivated models for dark matter clustering to construct statistical descriptions of the tSZ effect to all orders enabling us to determine the entire probability distribution function (PDF). Any generic deterministic biasing scheme can be incorporated in our analysis and the effects of projection, biasing and the underlying density distribution can be analysed separately and transparently in this approach. We introduce the cumulant correlators as tools to analyse tSZ catalogs and relate them to corresponding statistical descriptors of the underlying density distribution. The statistics of hot spots in frequency-cleaned tSZ maps are also developed in a self-consistent way to an arbitrary order, to obtain results complementary to those found using the halo model. We also consider different beam sizes, to check the extent to which the PDF can be extracted from various observational configurations. The formalism is presented with two specific models for underlying matter clustering: (1) the hierarchical ansatz; and (2) the lognormal distribution. We find both models to be in very good agreement with the simulation results, though the lognormal model has an edge over the hierarchical model.
description: 18 pages, 6 figures, Version accepted by MNRAS
X-linked juvenile retinoschisis: clinical diagnosis, genetic analysis, and molecular mechanisms
Creators: name: Molday, R. S.
name: Kellner, U.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: X-linked retinoschisis, Molecular genetics, Retinoschisin, Disease mechanisms, Clinical diagnosis, Gene therapy
subject: 610 Medizin

description: X-linked juvenile retinoschisis (XLRS, MIM 312700) is a common early onset macular degeneration in males characterized by mild to severe loss in visual acuity, splitting of retinal layers, and a reduction in the b-wave of the electroretinogram (ERG). The RS1 gene (MIM 300839) associated with the disease encodes retinoschisin, a 224 amino acid protein containing a discoidin domain as the major structural unit, an N-terminal cleavable signal sequence, and regions responsible for subunit oligomerization. Retinoschisin is secreted from retinal cells as a disulphide-linked homo-octameric complex which binds to the surface of photoreceptors and bipolar cells to help maintain the integrity of the retina. Over 190 disease-causing mutations in the RS1 gene are known with most mutations occurring as non-synonymous changes in the discoidin domain. Cell expression studies have shown that disease-associated missense mutations in the discoidin domain cause severe protein misfolding and retention in the endoplasmic reticulum, mutations in the signal sequence result in aberrant protein synthesis, and mutations in regions flanking the discoidin domain cause defective disulphide-linked subunit assembly, all of which produce a non-functional protein. Knockout mice deficient in retinoschisin have been generated and shown to display most of the characteristic features found in XLRS patients. Recombinant adeno-associated virus (rAAV) mediated delivery of the normal RS1 gene to the retina of young knockout mice result in long-term retinoschisin expression and rescue of retinal structure and function providing a ‘proof of concept’ that gene therapy may be an effective treatment for XLRS.
Additional file 1 of Suboptimal control status of young hypertensive population
Creators: name: Shin, Donghun
name: Choi, JungMin
name: Lee, Hae-Young
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table S1. Definition of socio-medical risk factors.
Electric-magnetic duality of lattice systems with topological order
Creators: name: Buerschaper, Oliver
name: Christandl, Matthias
name: Kong, Liang
name: Aguado, Miguel
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We investigate the duality structure of quantum lattice systems with topological order, a collective order also appearing in fractional quantum Hall systems. We define electromagnetic (EM) duality for all of Kitaev's quantum double models based on discrete gauge theories with Abelian and non-Abelian groups, and identify its natural habitat as a new class of topological models based on Hopf algebras. We interpret these as extended string-net models, whereupon Levin and Wen's string-nets, which describe all intrinsic topological orders on the lattice with parity and time-reversal invariance, arise as magnetic and electric projections of the extended models. We conjecture that all string-net models can be extended in an analogous way, using more general algebraic and tensor-categorical structures, such that EM duality continues to hold. We also identify this EM duality with an invertible domain wall. Physical applications include topology measurements in the form of pairs of dual tensor networks.
description: v2: material added, 24 pages, 7 figures
Certified to Drive: A Policy Proposal for Mandatory Training on Semi-Automated Vehicles
Creators: name: Mukherjee, Soumita
name: Parekh, Varun Darshana
name: Tayal, Nikhil
Publisher: name: arXiv
Year: 2025
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Although the Boeing 737 Max incidents resulted from a mix of design shortcomings, regulatory oversights, and systemic issues, they also highlight a critical gap in pilot training on managing automated systems during abnormal conditions. This example demonstrates the urgent need for focused, concise training on human-automation interaction - a need that is equally critical for operators of Level 2 ADAS-equipped vehicles, as discussed in detail later in this article. The lack of structured education for semi-automated vehicle operators mirrors similar risks in other industries, where formal training is critical for safe operation. Two policy recommendations are proposed. First, governments should create concise, official resources in accessible and official format to educate drivers on system capabilities and limitations. Second, mandatory training and certification programs should be introduced, combining theoretical and hands-on components to prepare drivers for real-world scenarios. These measures will improve driver understanding, reduce misuse, and foster public trust in semi-automated vehicle technologies. By addressing the knowledge gap, policymakers can ensure a safer, more responsible transition to automation, maximizing its benefits while minimizing risks to public safety.
Counting or producing all fixed cardinality transversals
Creators: name: Wild, Marcel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: An algorith to count, or alternatively generate, all k-element transversals of a set system is presented and compared with three known methods. For special cases it works in output-linear time.
description: This improves upon the previous version, and is to appear (with identical content) in Algorithmica