cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The biology of environmental stress: adaptive responses in Sydney rock oysters (Saccostrea glomerata) from an urbanized estuary
Creators: name: Melwani, Aroon R.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis investigates the impacts of chronic exposure to environmenta ldisturbance on wild populations of Sydney rock oysters (Saccostrea glomerata) in the Sydney Harbour estuary. It examines the hypothesis that intergenerational exposure to chemical contaminants and altered hydrological conditions leads to localized adaptation of oyster populations at the subcellular level. Chapters 2 and 3 focus on Sydney rock oysters from four bays that exhibit strong gradients of disturbance allowing the selection of high- and low-impact sites within each embayment. Tissue chemistry and hydrological measurements illustrated a unique mixture of stressors that differed significantly between these sites. Proteomic analysis showed clear differences in oyster proteomes among sites, and these differences were consistent across the four bays tested (Chapter 2). In contrast, population genetic analysis found no substantial differentiation of neutral genetic markers (microsatellites) in oysters throughout thestudy area (Chapter 3). This suggests that the proteomic differences observed were not due to neutral genetic variation. Instead, it was concluded that proteomic differentiation between populations reflected either transient changes in gene expression and protein turnover, or longer-term alterations that may involve genome-level adaptation. Chapters 4 and 5 describe results of a recovery experiment that was conducted to differentiate between these two explanations for the differences observed between populations. Oysters were collected from high- and low-impact sites within a single bay and transferred to the laboratory where they were acclimated in clean seawater for 60 days. Proteomic analysis revealed that the concentrations of most proteins in oysters from the high-impact site rapidly returned to levels equivalent to the ambient state, as reflected by the proteomes of oysters from the low-impact site (Chapter 4). Thissuggests that responses to environmental disturbance were transient at the level of the proteome and that oysters rapidly returned to cellular homeostasis when the disturbance was removed. However, the transcriptional analysis found that the expression of numerous genes remained significantly altered in oysters from the high-impact site throughout the course of the 60-day recovery period in clean seawater (Chapter 5). It was concluded that oysters from populations that suffer chronic environmental disturbance can rapidly return to functional homeostasis once the disturbance is removed, whilst their transcriptome remains substantially altered. The data suggest transcriptional modification may be a mechanism for localized responses to stress.They are also consistent with long-term adaptation to chronic environmental stress over small spatial scales.
Additional file 1: Table S1. of Temporal migration patterns between natal locations of ruby-throated hummingbirds (Archilochus colubris) and their Gulf Coast stopover site
Creators: name: Zenzal, Theodore
name: Contina, Andrea
name: Kelly, Jeffrey
name: Moore, Frank
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Tissue and environmental Î´2H values used for the isoscape calibration step. Supplementary literature cited. (DOCX 14Â kb)
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
Creators: name: Yamanaka, N.
name: Sahoo, B. K.
name: Yoshinaga, N.
name: Sato, T.
name: Asahi, K.
name: Das, B. P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The current status of electric dipole moments of diamagnetic atoms which involves the synergy between atomic experiments and three different theoretical areas -- particle, nuclear and atomic is reviewed. Various models of particle physics that predict CP violation, which is necessary for the existence of such electric dipole moments, are presented. These include the standard model of particle physics and various extensions of it. Effective hadron level combined charge conjugation (C) and parity (P) symmetry violating interactions are derived taking into consideration different ways in which a nucleon interacts with other nucleons as well as with electrons. Nuclear structure calculations of the CP-odd nuclear Schiff moment are discussed using the shell model and other theoretical approaches. Results of the calculations of atomic electric dipole moments due to the interaction of the nuclear Schiff moment with the electrons and the P and time-reversal (T) symmetry violating tensor-pseudotensor electron-nucleus are elucidated using different relativistic many-body theories. The principles of the measurement of the electric dipole moments of diamagnetic atoms are outlined. Upper limits for the nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained combining the results of atomic experiments and relativistic many-body theories. The coefficients for the different sources of CP violation have been estimated at the elementary particle level for all the diamagnetic atoms of current experimental interest and their implications for physics beyond the standard model is discussed. Possible improvements of the current results of the measurements as well as quantum chromodynamics, nuclear and atomic calculations are suggested.
description: 46 pages, 19 tables and 16 figures. A review article accepted for EPJA
Randomised clinical trials: statistical investigations of bias, inefficiency and misinterpretation
Creators: name: Schou, Ishani Manjula
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Randomised clinical trials (RCTs) compare treatment interventions using the health out-comes of individuals assigned to their treatment at random. RCTs are the gold standard for comparing treatment efficacy, but many factors in their design, conduct and analysis can lead to bias, inefficiency or misinterpretation. This thesis by publication presents statistical investigations of three such areas. The first area relates to potential bias from early stopping of RCTs. Some researchers have claimed that early stopping of RCTs based on interim analyses leads to overestimation of the treatment effect and that this is particularly problematic for meta-analyses that synthesise the results of multiple studies. This thesis presents extensive theoretical and simulation studies of this potential source of bias. It is concluded that early stopping is not a substantive sourceof bias for meta-analyses of RCTs. The second area relates to the potential for misinterpretation of RCT subgroup analyses, particularly subgroups defined by geographical region in global studies. Subgroup analysis principles require a significant test of interaction to conclude heterogeneity of subgroup treatment effects. However, overly optimistic expectations of treatment effect homogeneity often lead to over-interpretation of apparent differences between subgroups. This thesis proposes a suite of graphical analyses that supplement a test of interaction with a visual assessment of the extent to which chance can explain the observed differences between subgroups. An open-source software package for the R computing environment is presented. The third area relates to efficient design of RCTs having several treatments compared to a common control. Standard balanced designs have equal numbers of individuals on each treatment, but are inefficient in this context. This thesis considers efficient unbalanced designs that minimise variance or maximise power. New results in optimal design theory, and some guidelines for the efficient planning of RCTs having several treatments, are presented.
The need to refine the standard recombination theory and the Hubble tension problem
Creators: name: Shepelev, A. V.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Over the past decades, cosmology has become largely based on experimental data, the most important sources of which are studies of the cosmic microwave background (CMB). CMB is present in the Universe since the very first moments of its existence, and the features of CMB recorded now reflect the fundamental processes of the evolution of the Universe. These processes cause a weak anisotropy of CMB, which is no more than 0.01 percent. The structure of anisotropy, which is interpreted on the basis of a sufficiently detailed standard theory of primary recombination, allows us to establish the most important cosmological parameters. One of these parameters is the Hubble constant (more precisely, the Hubble parameter). However, the difference between the value of the Hubble constant, obtained from the results of the Planck mission, and obtained from independent local measurements, is 10%. Such a big difference is called the Hubble tension problem, and is an important problem of cosmology. The interpretation of the Planck measurements (as well as the interpretation of WMAP results, where a close value of the Hubble constant is obtained) is critically based on the predictions of the standard recombination theory. This work shows that the recombination rate is higher than predicted by standard theory and is caused by the excitation of the kinetic degrees of freedom of hydrogen atoms, which is ignored by standard theory. The calculations performed demonstrate that taking into account this process leads to a good coincidence of the values of the Hubble constant obtained from the results of the Planck experiment and local measurements.
description: 6 pages, 0 figures
title: Affiche de la conférence de Ph. Boissinot dans le cadre de l'OPI
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: Affiche de la conférence de Ph. Boissinot dans le cadre de l'OPI dans le cadre de l'OPI organisé par LabexMed le 9 décembre 2015
description: Relation: http://labexmed.hypotheses.org/1765
Combining Neuroevolution with the Search for Novelty to Improve the Generation of Test Inputs for Games
Creators: name: Feldmeier, Patric
name: Fraser, Gordon
Publisher: name: arXiv
Year: 2024
Subjects: subject: Software Engineering (cs.SE)
subject: Machine Learning (cs.LG)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: As games challenge traditional automated white-box test generators, the Neatest approach generates test suites consisting of neural networks that exercise the source code by playing the games. Neatest generates these neural networks using an evolutionary algorithm that is guided by an objective function targeting individual source code statements. This approach works well if the objective function provides sufficient guidance, but deceiving or complex fitness landscapes may inhibit the search. In this paper, we investigate whether the issue of challenging fitness landscapes can be addressed by promoting novel behaviours during the search. Our case study on two Scratch games demonstrates that rewarding novel behaviours is a promising approach for overcoming challenging fitness landscapes, thus enabling future research on how to adapt the search algorithms to best use this information.
description: 6 pages, 5 figures, Foundations of Applied Software Engineering for Games Workshop (FaSE4Games 2024)
Increasing blackhole feedback induced quenching with anisotropic thermal conduction
Creators: name: Kannan, Rahul
name: Vogelsberger, Mark
name: Pfrommer, Christoph
name: Weinberger, Rainer
name: Springel, Volker
name: Hernquist, Lars
name: Puchwein, Ewald
name: Pakmor, Ruediger
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Feedback from central supermassive blackholes is often invoked to explain the low star formation rates in massive galaxies at the centers of galaxy clusters. However, the detailed physics of the coupling of the injected feedback energy with the intracluster medium is still unclear. Using high-resolution magnetohydrodynamic cosmological simulations of galaxy cluster formation, we investigate the role of anisotropic thermal conduction in shaping the thermodynamic structure of clusters, and, in particular, in modifying the impact of black hole feedback. Stratified anisotropically conducting plasmas are formally always unstable, and thus more prone to mixing, an expectation borne out by our results. The increased mixing efficiently isotropizes the injected feedback energy which in turn significantly improves the coupling between the feedback energy and the intracluster medium. This facilitates an earlier disruption of the cool core, reduces the star formation rate by more than an order of magnitude, and results in earlier quenching despite an overall lower amount of feedback energy injected into the cluster core. With conduction, the metallicity gradients and dispersions are lowered, aligning them better with observational constraints. These results highlight the important role of thermal conduction in establishing and maintaining quiescence of massive galaxies.
description: 5 pages, 5 figures, Submitted to ApJ Letters
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0177
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0177, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0177, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Hard MHD limit in $1/3$ sawtooth like activity in LHD
Creators: name: Varela, J.
name: Watanabe, K. Y.
name: Ohdachi, S.
name: Narushima, Y.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The optimization of LHD discharges in inward-shifted configurations with $1/3$ sawtooth like activity is an open issue. These relaxation events limit the LHD performance driving a periodic plasma deconfinement. The aim of this study is to analyze the $1/3$ sawtooth like activity in plasmas with different stability properties to foreseen the best operation conditions and minimize its undesired effects. We summarize the results of several MHD simulations for plasmas with Lundquist numbers between $10^5$ and $10^6$ in the slow reconnection regime, studying the equilibria properties during the onset of a chain of $1/3$ sawtooth like events. The research conclusions point out that the hard MHD limit can be reached in the inner plasma region after the onset of a strong $1/3$ resonant sawtooth like event and trigger a plasma collapse. The collapse can be avoided if the system remains in the soft MHD limit, namely in a regime with a pressure gradient and a magnetic turbulence below the critical values to drive the soft-hard MHD transition. In the soft MHD limit the system relaxations are the non resonant $1/3$ sawtooth like events or a weak version of the $1/3$ resonant sawtooth like events. A system relaxation in the soft MHD regime drives a minor plasma deconfinement that doesn't limit the LHD performance if the event periodicity is not very high.
Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
Creators: name: Tang, Shengnan
name: Wang, Aiping
name: Yan, Xiuju
name: Chu, Liuxiang
name: Yang, Xiucheng
name: Song, Yina
name: Sun, Kaoxiang
name: Yu, Xin
name: Liu, Rongxia
name: Wu, Zimei
name: Xue, Peng
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Medicine
Cell Biology
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mental Health

description: Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. In vitro cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. In vivo pharmacokinetic studies indicated that AUC0–12 h in the rat brain for dopamine Lf-BNPs was significantly higher (p < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson’s disease.
Additional file 2: of Extending coverage to informal sector populations in Kenya: design preferences and implications for financing policy
Creators: name: Okungu, Vincent
name: Chuma, Jane
name: Mulupi, Stephen
name: McIntyre, Diane
Publisher: name: figshare
Year: 2018
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: FGD. Data here is qualitative and involves discussions around the various ways to prepay for health care. (DOCX 17 kb)
Shakta Tantric Hinduism, Vajrayana Buddhism & Jainism: The Goddess Unites Across Dharma Traditions
Creators: name: Timalsina, Staneshwar
Publisher: name: Zenodo
Year: 2023
Subjects: Tantric philosophy
anava upaya
yantra
amnaya
Shiva
Shaiva
vimarsha-foundation
consciousness
mahadeva
Vasugupta
Sarvamnaya
tripura
Durga
Kaula
Abhinavagupta
Shiva Sutra
Kula
saivadvaita
vedanta
Mahakali
Tantra
Chandi
Kali
advaita vedanta
Bhairava
shambhava
timalsina
Spanda
Kashmir Shaivism
krama
Saundaryalahari
Tripura Rahasya
Tripurasundari
Camunda
agama
Devi Mahatmya
sarvamnaya
Guhyakālī
shakti
tantraloka
Divine Mother
sarvamnaya-oral-tradition-archive
trika
sthaneshwar timalsina
Īśāna
Mālinīvijayottaratantra
shakta upāya
Kubjika
Sadāśiva

description: Acharya Dr. Sthaneshwar Timalsina is an esteemed traditional consecrated teacher of Shaiva-Shakta Hindu Tantra. He is also the Endowed Chair of Indic Studies at Stony Brook University, New York in the Department of Asian & Asian American Studies. Acharya Sthaneshwar is the founder of Vimarsha Foundation, a non-profit organization through which he teaches shāstra and sādhanā to students of all backgrounds. Learn more about Vimarsha on our website, learn from our many free Tantra resources, and join us for free shāstra courses that occur every semester: https://www.vimarshafoundation.org/

This video is an excerpt of a talk that Acharyaji delivered to Global Mandala during Navaratri the previous year. Watch the full discussion from our Talks Playlist: https://youtube.com/playlist?list=PLfbgwkldU93cgwIqN6g0cQZcqP5OlK6un&si=iGMF9Od21LLra0v7.

#vajrayana #hinduism #tantra #dharma

Original YouTube video: https://www.youtube.com/watch?v=4o28jbNrU4k

This presentation is part of the Sarvāmnāya Oral Tradition Archive.
Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
SDSS-IV MaNGA: environmental dependence of stellar age and metallicity gradients in nearby galaxies
Creators: name: Zheng, Zheng
name: Wang, Huiyuan
name: Ge, Junqiang
name: Mao, Shude
name: Li, Cheng
name: Li, Ran
name: Mo, Houjun
name: Goddard, Daniel
name: Bundy, Kevin
name: Li, Hongyu
name: Nair, Preethi
name: Lin, Lihwai
name: Long, R. J.
name: Riffel, Rogerio
name: Thomas, Daniel
name: Masters, Karen
name: Bizyaev, Dmitry
name: Brownstein, Joel R.
name: Zhang, Kai
name: Law, David R.
name: Drory, Niv
name: Lopes, Alexandre Roman
name: Malanushenko, Olena
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a study on the stellar age and metallicity distributions for 1105 galaxies using the STARLIGHT software on MaNGA integral field spectra. We derive age and metallicity gradients by fitting straight lines to the radial profiles, and explore their correlations with total stellar mass M*, NUV-r colour and environments, as identified by both the large scale structure (LSS) type and the local density. We find that the mean age and metallicity gradients are close to zero but slightly negative, which is consistent with the inside-out formation scenario. Within our sample, we find that both the age and metallicity gradients show weak or no correlation with either the LSS type or local density environment. In addition, we also study the environmental dependence of age and metallicity values at the effective radii. The age and metallicity values are highly correlated with M* and NUV-r and are also dependent on LSS type as well as local density. Low-mass galaxies tend to be younger and have lower metallicity in low-density environments while high-mass galaxies are less affected by environment.
description: 18 pages, 24 figures, accepted for publication in MNRAS
Additional file 9: Figure S3. of Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF
Creators: name: Ramalho, Albina
name: Bombassaro, Bruna
name: Dragano, Nathalia
name: Solon, Carina
name: Joseane Morari
name: Fioravante, Milena
name: Barbizan, Roberta
name: Velloso, Licio
name: Araujo, Eliana
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology

description: Immunofluorescence staining of markers of the median eminence blood-brain barrier and markers of glial cells. Immunofluorescence staining using primary antibodies against IGFBP2 (green), GFAP (red) (A), and IBA1 (red) (B). Specimens were obtained from bregma-anteroposterior − 2.06 to − 2.18. The images are representative of three independent experiments. 3v, third ventricle; IGFBP2, insulin-like growth factor-binding protein 2; GFAP, glial fibrillary acidic protein; IBA1, ionized calcium-binding adapter molecule-1. (PDF 17432 kb)
On classification and invariants of second order non-parabolic linear partial differential equations in two variables
Creators: name: Bekbaev, U.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: Primary 35A99, Secondary 35J15, 35L10, 12H20

description: The paper deals with second order abstract linear partial differential equations (LPDE) over a partial differential field with two commuting differential operators. In terms of usual differential equations the main content can be presented as follows. The classification and invariants problems for second order LPDEs with respect to transformations \[x=x(ξ,η),\ y=y(ξ,η),\ u=h(x,y)v(ξ,η),\] where $x,y$ are independent and $u$ is the dependent variable of the LPDE, are considered. Solutions to these problems are given for different subclasses of non-parabolic LPDE which appear naturally in the equivalence problem of LPDE. A criterion for reducibility of such LPDE to LPDE with constant coefficients is offered as well.
Premature failure analysis of single row, deep groove bearings from idler rollers used on mine sites
Creators: name: O'Farrell, Patrick
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Bearings are vital to the operation and efficiency of millions of systems as they allow components to rotate freely with minimal resistance or stress. They are particularly important on belt conveyors which are widely used on mine sites (the specifics of a belt conveyor system will be discussed in more detail later on). It is a common occurrence for idler rollers (the cylindrical pipes upon which the belt slides across) to fail prematurely, causing damage to the belt conveyor and resulting in down-time of the mining operations, consequently costing mining companies hundreds of thousands of dollars. For this reason, it is beneficial to perform a detailed failure analysis of these idler rollers, focusing on the bearings as these are the common point of premature failure. This thesis paper will contain mathematical models simulating the mechanical loads on a bearing using computer simulations in ANSYSY Workbench as well as practical work on damaged idler rollers where a failure analysis will be carried out. This experimental work will consist of a series of pictures taken using a camera as well as an optical microscope for detailed views of the internal surfaces of the bearings. A detailed analysis of the findings will be presented in the discussion.
Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
Creators: name: Tang, Shengnan
name: Wang, Aiping
name: Yan, Xiuju
name: Chu, Liuxiang
name: Yang, Xiucheng
name: Song, Yina
name: Sun, Kaoxiang
name: Yu, Xin
name: Liu, Rongxia
name: Wu, Zimei
name: Xue, Peng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Medicine
Cell Biology
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mental Health

description: Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. In vitro cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. In vivo pharmacokinetic studies indicated that AUC0–12 h in the rat brain for dopamine Lf-BNPs was significantly higher (p < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson’s disease.
Ubiquitous Integrated Sensing and Communications for Massive MIMO LEO Satellite Systems
Creators: name: You, Li
name: Zhu, Yongxiang
name: Qiang, Xiaoyu
name: Tsinos, Christos G.
name: Wang, Wenjin
name: Gao, Xiqi
name: Ottersten, Björn
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: Information Theory (cs.IT)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: The next sixth generation (6G) networks are envisioned to integrate sensing and communications in a single system, thus greatly improving spectrum utilization and reducing hardware costs. Low earth orbit (LEO) satellite communications combined with massive multiple-input multiple-output (MIMO) technology holds significant promise in offering ubiquitous and seamless connectivity with high data rates. Existing integrated sensing and communications (ISAC) studies mainly focus on terrestrial systems, while operating ISAC in massive MIMO LEO satellite systems is promising to provide high-capacity communication and flexible sensing ubiquitously. In this paper, we first give an overview of LEO satellite systems and ISAC and consider adopting ISAC in the massive MIMO LEO satellite systems. Then, the recent research advances are presented. A discussion on related challenges and key enabling technologies follows. Finally, we point out some open issues and promising research directions.
description: 6 pages,4 figures
Development of synthetic high-density lipoprotein-based ApoA-I mimetic peptide-loaded docetaxel as a drug delivery nanocarrier for breast cancer chemotherapy
Creators: name: Gong, Miaomiao
name: Zhang, Qi
name: Zhao, Qi
name: Zheng, Jiani
name: Li, Yue
name: Wang, Siling
name: Yuan, Yue
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: In this study, a synthetic high-density lipoprotein (sHDL), peptide-based nanocarrier loaded with docetaxel (DTX) was constructed, against breast cancer. The thermodynamic and molecular dynamic analyses were conducted to examine the stability of nanoparticles synthesized from mimetic peptide 5 A and various types of phospholipids. Furthermore, the cellular uptake and in vivo fluorescence imaging analysis experiments, with scavenger receptor B-I (SR-BI) were carried out to examine the tumor-targeting ability of sHDL. The nanoparticles were investigated for their pharmacodynamic and cytotoxic effects to show their effectivity as anti-tumor agents. The results showed that the synthesized sHDL nanoparticles exhibited a high payload of DTX, sustained drug release properties, and excellent biocompatibility. Moreover, DTX-sHDL nanoparticles enhanced the uptake of DTX, increased the cytotoxicity against MCF-7 cells, and reduced the off-target side-effects to normal cells. Finally, experiments in 4T1 cell line-bearing mice indicate that inhibition of tumor growth by DTX-sHDL nanoparticles was superior to that of free DTX group. Thus, the sHDL nanoparticles are a promising drug delivery vehicle for improving the efficacy of anti-cancer drugs.
Using species traits to understand reef coral distributions and responses to stress
Creators: name: Mizerek, Tony
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Coral reef ecosystems provide important ecological goods and services, but are threatened by climate change and other anthropogenic impacts. The numerous scleractinian coral species that build coral reefs vary in tolerance to environmental conditions and stressors. Therefore, in response to environmental change, coral reefs are likely to change significantly rather than disappear completely. Explicitly quantifying relationships between corals and their environment will provide a better understanding of the mechanisms influencing species distributions and local persistence. However, the lack of overlap in the composition of coral assemblages across different geographic regions has limited the development of a broad-scale understanding of global coral-environment relationships. In this thesis, I therefore focused on species traits to describe biogeographical patterns over large spatial scales, which enabled an integrated, systematic approach for explicitly linking environmental conditions with species distributions. This thesis specifically aimed to: 1) quantify multi-decadal change in coral assemblages within a climate change hotspot, 2) characterize species traits that dominate marginal environments globally, 3) model multiple species distributions in relation to species traits along environmental gradients, and 4) quantify how species traits mediate the responses of corals to a key environmental stressor (increased sea surface temperature, SST). I used a variety of techniques including conducting field surveys, collating published coral distribution data, analyzing bleaching surveys, and applying statistical modeling techniques to investigate coral distributions and responses to stressors. My research resulted in several key findings. First, I unexpectedly found little evidence of change in assembly structure of high latitude reef corals in southeast Australia over the last 20 years where SST has increased. Second, reef corals found at high latitudes - beyond reef growth - were generally found to share traits associated with environmental tolerance, as opposed to dispersal potential. Third, I incorporated coral traits into a multispecies distribution model to quantify how three traits modulate responses to three environmental gradients across northeast Australia. The strongest link was a positive response between species depth range and SST variability. Finally, I demonstrated that growth form and family explain more variation in global coral bleaching responses than other morphological or physiological traits; hence including these traits in bleaching surveys will increase predictive power of surveys. My thesis has generated a richer understanding of coral trait-environment relationships, which ultimately allows for more accurate predictions of the ways in which future environmental changes will impact different coral species.
On the likelihood of detecting gravitational waves from Population III compact object binaries
Creators: name: Belczynski, K.
name: Ryu, T.
name: Perna, R.
name: Berti, E.
name: Tanaka, T. L.
name: Bulik, T.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the contribution of binary black hole (BH-BH) mergers from the first, metal-free stars in the Universe (Pop III) to gravitational wave detection rates. Our study combines initial conditions for the formation of Pop III stars based on N-body simulations of binary formation (including rates, binary fraction, initial mass function, orbital separation and eccentricity distributions) with an updated model of stellar evolution specific for Pop III stars. We find that the merger rate of these Pop III BH-BH systems is relatively small (< 0.1 Gpc^-3 yr^-1) at low redshifts (z<2), where it can be compared with the LIGO empirical estimate of 9-240 Gpc^-3 yr^-1 (Abbott et al. 2016). The predicted rates are even smaller for Pop III double neutron star and black hole neutron star mergers. Our rates are compatible with those of Hartwig et al. (2016), but significantly smaller than those found in previous work (Bond & Carr 1984; Belczynski et al. 2004; Kinugawa et al. 2014, 2016). We explain the reasons for this discrepancy by means of detailed model comparisons and point out that (i) identification of Pop III BH-BH mergers may not be possible by advanced LIGO, and (ii) the level of stochastic gravitational wave background from Pop III mergers may be lower than recently estimated (Kowalska et al. 2012; Inayoshi et al. 2016; Dvorkin et al. 2016). We further estimate gravitational wave detection rates for third-generation interferometric detectors. Our calculations are relevant for low to moderately rotating Pop III stars. We can now exclude significant (> 1 per cent) contribution of these stars to low-redshift BH-BH mergers. However, it remains to be tested whether (and at what level) rapidly spinning Pop III stars (homogeneous evolution) can contribute to BH-BH mergers in the local Universe.
description: submitted to MNRAS, comments welcome
Magnetic turbulence and pressure gradient feedback effect of the $1/2$ mode soft-hard MHD limit in Large Helical Device
Creators: name: Varela, J.
name: Watanabe, K. Y.
name: Ohdachi, S.
name: Narushima, Y.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The aim of this study is to analyze the feedback process between the magnetic turbulence and the pressure gradients in LHD inward-shifted configurations as well as its role in the transition between the soft-hard MHD regimes for instabilities driven by the mode $1/2$ in the middle plasma. In the present paper we summarize the results of two simulations with different Lundquist numbers, $S = 2.5 \times 10^5$ and $10^6$, assuming a plasma in the slow reconnection regime. The results for the high Lundquist number simulation shows that the magnetic turbulence and the pressure gradient in the middle plasma region of LHD are below the critical value to drive the transition to the hard MHD regime, therefore only relaxations in the soft MHD limit are triggered ($1/2$ sawtooth like events) [Phys. Plasmas 19, 082512 (2012)]. In the case of the simulation with low Lundquist number, the system reaches the hard MHD limit and a plasma collapse is observed.
Analytic properties of American option prices under a modified Black-Scholes equation with spatial fractional derivatives
Creators: name: Chen, Wenting
name: Du, Kai
name: Qiu, Xinzi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computational Finance (q-fin.CP)
subject: FOS: Economics and business

description: This paper investigates analytic properties of American option prices under the finite moment log-stable (FMLS) model. Under this model the price of American options is characterised by the free boundary problem of a fractional partial differential equation (FPDE) system. Using the technique of approximation we prove that the American put price under the FMLS model is convex with respect the underlying price, and specify the impact of the tail index on option prices.
description: 12 pages
Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions
Creators: name: Chu, Edward Rickie Lim
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Glaucoma is the leading cause of irreversible blindness in the world and remains a devastating ophthalmic condition. Current management seems limited and focuses mainly on reducing intraocular pressure. Glaucoma research models such as cell and organ based culture, computer simulation and animal models have played major roles in advancing the field, however, disease progression still occurs indicative that the pathophysiology of glaucoma has not been fully elucidated. In an attempt to shed some light into this issue, a novel artificial hydraulic model has been developed to empirically simulate fluid dynamics of the human conventional outflow pathway. Using non-biological materials, this model comprised of critical elements of the human aqueous outflow tract that include a microsyringe pump (simulating aqueous inflow/outflow), 35-gauge needle (stimulating trabecular meshwork), one way valve (simulating Schlemm’s canal inner wall endothelia) and a distal fluid column (simulating episcleral venous pressure) interconnected in between by pressure transducers and rigid tubings. The model was able to replicate various components of the conventional outflow pathway under physiological and pathological conditions. This system can potentially provide options to incorporate biological materials (i.e. cell cultures), include a parallel uveoscleral outflow system and/or simulate collector channel resistance to create a more comprehensive model to further our understanding in aqueous outflow dynamics.
Chameleon Mechanism in Scalar Nonmetricity Cosmology
Creators: name: Paliathanasis, Andronikos
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the dynamics and the phase-space evolution for the scalar nonmetricity cosmology with a Chameleon mechanism. In particular, we consider a spatially flat Friedmann--Lema\^ıtre--Robertson--Walker geometry and within the framework of scalar nonmetricity theory, we consider a generalization of the Brans-Dicke theory in nonmetricity gravity. Introducing a pressureless gas as the matter source, we also incorporate a coupling function responsible for the interaction. Our findings reveal that the choice of connection in nonmetricity gravity significantly impacts the interaction between the scalar field and the matter source. For one particular connection, we discover the absence of asymptotic solutions with a nontrivial interacting component. More precisely, in this scenario, the matter source does not directly interact with the scalar field; however, there is an interaction with the dynamical degrees of freedom provided by the connection.
description: 28 pages, 4 Figures
Gaia's view of the $λ$ Boo star puzzle
Creators: name: Murphy, Simon J.
name: Paunzen, Ernst
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The evolutionary status of the chemically peculiar class of $λ$ Boo stars has been intensely debated. It is now agreed that the $λ$ Boo phenomenon affects A stars of all ages, from star formation to the terminal age main sequence, but the cause of the chemical peculiarity is still a puzzle. We revisit the debate of their ages and temperatures in order to shed light on the phenomenon, using the new parallaxes in Gaia Data Release 1 with existing Hipparcos parallaxes and multicolour photometry. We find that no single formation mechanism is able to explain all the observations, and suggest that there are multiple channels producing $λ$ Boo spectra. The relative importance of these channels varies with age, temperature and environment.
description: 10 pages, 3 figures, fine for greyscale printing but colour is better
Localisation and expression of aquaporin-4 around arterioles, venules and capillaries in the rat spinal cord
Creators: name: Cusick, Thomas
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The traditional view of cerebrospinal fluid (CSF) circulation within the central nervous system (CNS) is that CSF is produced within the choroid plexus, flows slowly through the subarachnoid space (SAS). and is reabsorbed by arachnoid villi or around spinal nerves. Despite acceptance of this viewpoint, the mechanism by which CSF is moved around the CNS is not fully understood. Our current understanding of CSF flow within the brain is that fluid inflow occurs predominantly around peri-arterial spaces, whilst outflow occurs around peri-venular spaces. This fluid movement is believed to be mediated by the protein aquaporin-4 (AQP4). Whether AQP4 contributes to the movement of CSF within the spinal cord remains to be determined. The aim of the following study was to assess AQP4 expression in the rodent spinal cord in relation to microvascular structures. Multiple labelling immunohistochemistry was performed on 6 and 12 week old rats to distinguish arterioles from venules, and capillaries were identified by measuring the diameter of each stained vessel. AQP4 was found around both arterioles and venules within the rodent spinal cord, and was expressed in higher levels in the younger rats. No overall difference was found between AQP4 expression levels around arterioles, venules and capillaries, however, expression of AQP4 was found to decrease as the diameter of arterioles increased. The results of this study lay the foundation for future experiments to assess the effect of AQP4 antagonism on fluid flow within the spinal cord.
Optical vortex knots - one photon at a time
Creators: name: Tempone-Wiltshire, Sebastien
name: Johnstone, Shaun
name: Helmerson, Kristian
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Feynman described the double slit experiment as "a phenomenon which is impossible, absolutely impossible, to explain in any classical way and which has in it the heart of quantum mechanics". The double slit experiment, performed one photon at a time, dramatically demonstrates the particle-wave duality of quantum objects by generating a fringe pattern corresponding to the interference of light (a wave phenomenon) from two slits, even when there is only one photon (a particle) at a time passing through the apparatus. The particle-wave duality of light should also apply to complex three dimensional optical fields formed by multi-path interference, however, this has not been demonstrated. Here we observe particle-wave duality of a three dimensional field by generating a trefoil optical vortex knot - one photon at a time. This result demonstrates a fundamental physical principle, that particle-wave duality implies interference in both space (between spatially distinct modes) and time (through the complex evolution of the superposition of modes), and has implications for topologically entangled single photon states, orbital angular momentum multiplexing and topological quantum computing.
description: 6 pages, 3 figures