cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of a6* nAChR-mediated signaling in nicotine withdrawal
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking is a leading cause of preventable deaths throughout the world as it leads to cancer, cardiovascular and pulmonary disease, and increased susceptibility to numerous other illnesses. Although these detrimental effects of tobacco use are probably not due to nicotine but to numerous irritants and/or carcinogens in smoke/tobacco, nicotine is a major psychoactive ingredient in tobacco that contributes to addiction and the smoking habit. Most smokers express a desire to quit. However, quitting smoking is often very challenging due to withdrawal symptoms that lead to frequent relapse. Clinical trials with nicotine replacement, bupropion or varenicline show that these treatments improve quit rates, with varenicline yielding the best results. However, the average success rate with varenicline is ~25%, and its use is associated with side effects such that its use must be discontinued. Thus, there is a pressing need to better understand the mechanisms related to nicotine addiction in order to develop improved therapeutic strategies. Smoking produces its pleasurable effects in the brain by acting at receptors that have a strong affinity for nicotine and are therefore called nicotinic receptors. There are multiple subtypes of nicotinic receptors in the brain that are linked to the maintenance of the smoking habit as well as the unpleasant symptoms that arise with smoking cessation. Of these, our work focuses on the role of a nicotinic receptor subtype known as alpha6beta2* receptors since these are exclusively localized to brain cells that produce dopamine, a chemical in the brain that is strongly involved in the rewarding effects of addictive drugs such as nicotine. Importantly, alpha6beta2* receptors are not expressed in the peripheral system. Thus, drugs targeting these receptors may have fewer side effects and consequently increase smoking cessation rates. Nicotine interacts with nicotinic receptors to control dopamine levels in the brain, with alpha6beta2* receptors playing a crucial regulatory role. The proposed work will investigate how selectively activating and inhibiting dopamine cells expressing alpha6beta2* receptors affect behavior during nicotine exposure and after its discontinuation. In addition, we will determine how the activity of these cells modulate dopamine signaling and the subsequent molecular changes that occur. To achieve this, we will use optogenetics and chemogenetics which are two novel tools that will enable us to selectively control dopamine cells expressing alpha6beta2* receptors within the brain reward pathway. Experiments will be performed in animals undergoing nicotine treatment as well as 1 d and 15 d after nicotine withdrawal. The results from this work will provide evidence of whether manipulating alpha6beta2* receptor-mediated dopamine signaling represents a good target for the development of smoking cessation drugs.
Additional file 2: Figures S1â  S12. of xCell: digitally portraying the tissue cellular heterogeneity landscape
Creators: name: Aran, Dvir
name: Zicheng Hu
name: Butte, Atul
Publisher: name: Figshare
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: (PDF 7074 kb)
Miniopterus fuliginosus
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Miniopteridae
Miniopterus
Miniopterus fuliginosus

description: Miniopterus fuliginosus (Hodgson, 1835) —Eastern Bent-winged Bat
Ƒespertilio fuliginosa Hodgson, 1835 p.700; Type locality- Nepal.
Miniopterus schreibersii japoniae Thomas, 1905 p.338; Type locality- Miyazaki, Japan; Kishida & Mori, 1931 p.379; Kuroda, 1938 p.104.
M. schreibersii fuliginosus: Ellerman & Morrison-Scot, 1951 p.183; Won, 1958 p.459; Won, 1967 p.348; Won, 1968 p.127; Yoon, 1992 p.56; Yoon, 2010 p.86; Jo et al., 2012 p.252.
M. schreibersii: Won, 1968 p.127; Han, 1994 p.45; Won & Smith, 1999 p.15; Son, 2001 p.123; Yoon, 2004 p.90; Yoon, 2010 p.86.
Range: The distribution of this species ranges over the southern Korean Peninsula and Jeju Island (Son 2001; Fig. 39).
Remarks: M. fuliginosus was regarded as a subspecies of M. schreibersii and populations in Korea were considered M. schreibersii fuliginosus (Won 1967). Appleton et al. (2004) and Tian et al. (2004) split M. schreibersii into two distinct species using ND2 and cytochrome b, respectively. Therefore, M. schreibersii became assigned to Europe and M. fuliginosus earmarked for Asia (Šrámek et al. 2013). The closest taxon to M. fuliginosus is M. magnate rather than M. schreibersii (Kruskop et al. 2012). Although the Subspecies M. f. chinensis occurs in extreme southern Primorye, Russia-Korean border area (Kruskop 2012), the subspecific status of populations in Korea have rarely been studied.
Conservation status: The Red Data Book of North Korea lists this species as ‘Rare’.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 63, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Additional file 1: of The dose of behavioral interventions to prevent and treat childhood obesity: a systematic review and meta-regression
Creators: name: Heerman, William
name: JaKa, Meghan
name: Jerica Berge
name: Trapl, Erika
name: Sommer, Evan
name: Samuels, Lauren
name: Jackson, Natalie
name: Haapala, Jacob
name: Kunin-Batson, Alicia
name: Olson-Bullis, Barbara
name: Hardin, Heather
name: Sherwood, Nancy
name: Barkin, Shari
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Figure S1. Forest plot demonstrating a visual representation of the variability in standardized effect size. Table S1. Dose of behavioral intervention and intervention characteristics by study and a full reference list of all studies reviewed. Table provides details of all articles reviewed in this meta-regression. Table S2. Meta-regression evaluating the relationship between dose and standardized effect size stratified by study characteristics. (PDF 1938 kb)
Finite-difference and finite-element solution of boundary value and obstacle problems for the Heston operator
Creators: name: Osorio Triana, Eduardo
Publisher: name: No Publisher Supplied
Year: 2014

description: We develop fi nite-element and fi nite-diff erence methods for boundary value and obstacle  problems for the elliptic Heston operator. For the fi nite-element method we fi rst review  existence and uniqueness results for these problems on weighted Sobolev spaces, where  their variational formulations are formulated, and fi nite-dimensional subspaces are chosen  to fi nd approximating solutions, and obtain error estimates and numerical results.  Similarly, for the fi nite-difference method, we start by reviewing the existence, uniqueness  and regularity results on boundary value and obstacle problems on weighted H older  spaces, then consider  finite-difference operators, establish discrete maximum principles  for them, and obtain error estimates and numerical results.
Anti-HIV-1 restriction in hematopoietic stem cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Some cells have factors that halt virus infection after the virus has already entered the cell, make such cells resistant against certain viruses. Hematopoietic stem cells, which are cells in the bone marrow that can generate all types of blood cells, are resistant against infection by the HIV virus, but the factors responsible for this resistance have not been identified. Using HIV vectors, which are model viruses that replicate the early stages of the HIV life cycle but cannot generate new viruses, we have shown that only a small portion of hematopoietic stem cells can be infected, indicating that these cells can halt the early steps of HIV replication, thereby resisting infection. However, treating cells briefly with the drug rapamycin drastically increases the amount of cells that are infected by HIV vectors. Rapamycin is a clinically tested drug that has been used in suppressing organ transplant rejection and more recently in treating cancer; however, its use in managing susceptibility of hematopoietic stem cells to HIV infection is a novel finding. We hereby propose to study how rapamycin relieves the resistance against HIV in these cells. Understanding the molecular basis of HIV resistance is important for two reasons. Firstly, we may be able to modulate the cellular factors in question to make the target cells of HIV less susceptible to infection, allowing us to better combat HIV infection. Secondly, HIV vectors – non-replicating virus surrogates – can be used to insert therapeutic genes into hematopoietic stem cells, thus treating and potentially curing a number of blood-borne diseases including HIV infection and X-linked immunodeficiency (the bubble-boy syndrome). By providing a way to better target HIV vectors into hematopoietic stem cells, we can more efficiently utilize gene therapy to combat these diseases.
Miniopterus fuscus Bonhote 1902
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Miniopteridae
Miniopterus
Miniopterus fuscus

description: Miniopterus fuscus Bonhote, 1902 —Southeast Asian Long-fingered Bat
Miniopterus fuscus Bonhote, 1902 p.626; Type locality- Okinawa, Japan; Son, 2001 p.125; Jo et al., 2012 p.252.
Range: Only one female captured on 8 July 1986 on Jeju Island (Son 2001).
Remarks: The individual from Jeju Island is considered a vagrant from Japan (Son 2001). This species has seldom been listed as a mammal from Korea.
Conservation status: The IUCN Red List considers M. fuscus as ‘Endangered’.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 63, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Social mix in U.S. suburbs
Creators: name: Pangallozzi, Laura
Publisher: name: No Publisher Supplied
Year: 2014

description: This project considers the political, social, and cultural geography of black settlement in the inner suburbs of Newark between approximately 19&0 and 2010.  While the period just after the Newark riots of 196& saw the most dramatic changes in population in both the city of Newark itself and in its immediate suburbs (mainly population loss of all races), racial transition from white to black continued in inner suburbs into the 1990s and beyond. The responses of white residents to new black neighbors ranged from welcoming to violent and encompassed both formal interventions by municipal governments through an integration maintenance group that monitored the extent of black settlement and sought to educate whites as well as informal interventions such as aggressive policing and an anonymous campaign in the 1980s to vandalize the homes of black residents. In theoretical terms, how do we think about these reactions; additionally, how do we think about the outcomes? Foucault’s notion of governmentality, how local actors reinforce existing norms through a pattern of daily practices that are acted out, sometimes deliberately, but more often just below the surface of consciousness, was crucial in explaining the felt experience of daily life in the communities under study. The methods used in the study were analysis of Census data, archival data, focus groups, and interviews. Interventions in response to black settlement changed as black numbers, and so black agency, grew. Blacks acted successfully to check interventions designed to keep them from accessing the crucial advantages of suburbs, particularly in the schools and the safety of good policing.
Ctenagenia vespiformis
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ctenagenia
Ctenagenia vespiformis

description: Ctenagenia vespiformis (Klug, 1834)
Distribution in the Arabian Peninsula: Saudi Arabia (Wahis 2002), United Arab Emirates (Schmid-Egger 2017), Yemen (Kohl 1906 as Pompilus vespiformis; Guiglia 1955; Wahis 2000a, 2002).
Extralimital distribution: Palaearctic and Afrotropical (Kohl 1906; Guiglia 1955; Priesner 1955; Haupt 1962; Özbek et al. 2000; Wahis 2000a, 2002, 2005; Wolf 2004b, 2005; Yildirim & Wahis 2011; Ghahari et al. 2014).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 161, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Acromantis Saussure 1870
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Acromantis

description: Acromantis Saussure, 1870
A lineage of arboricolous species, also occurring on high weeds and scrubs. It includes twenty species distributed over SE Asia, Indonesia and N Australia. This is a taxonomically difficult genus and its species are hard to distinguish. There are six species listed for Borneo, but only two can definitely be confirmed at the moment.
Acromantis moultoni Giglio-Tos, 1915
Acromantis moultoni Giglio-Tos, 1915: 5
= Acromantis westwoodi Giglio-Tos, 1915: 7
Distribution. Java, Sumatra, Borneo, Sangi Islands, Talaud Islands (Werner 1930, 1933, Beier 1937, 1958, Ehrmann 2002).
Bornean records. Sarawak: Borneo Heights (CS in situ), Lanjak Entimau (4 m, 1 f, CSUB/SFDC), Mt. Dulit (Beier 1937); Brunei: Kuala Belalong (OK in situ); Sabah: Crocker Range (AFUW), Sorinsim (AFUW), Danum Valley (Helmkampf et al. 2007), Poring Hot Springs (Helmkampf et al. 2007; SMNK), Kalabakan (OK in situ), Sandakan (Hebard 1920), Darvel Bay (Giglio-Tos 1915a; ZMB); Kalimantan: Mentawir (Beier 1958).
Remarks. This species is common throughout most of northwestern Borneo. It is arboricolous and found in primary and disturbed habitats, preferring the inflorescences of weeds and shrubs in sunlit places. Females fly well and are also attracted to lights, although not as often as males. There are some uncertainties regarding the validity of this species, as the diagnostic features given by Giglio-Tos (1915, 1927) are highly variable, particularly regarding the tubercle on the vertex and the color of the antero-ventral profemoral spines, which vary considerably among specimens. Hebard (1920) and Werner (1922) pointed out that A. moultoni may be a synonym of A. oligoneura (De Haan, 1842).
Acromantis dyaka Hebard, 1920
Distribution. N Borneo: Sabah: Labuan (Hebard 1920); Mt. Kinabalu (SMNK).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 139, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Search for extended Higgs Sector at the LHC using multileptons and photons in the final state
Creators: name: Panwalkar, Shruti M.
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation describes the search for an extension of the Higgs sector to Two Higgs Doublet Models. This entails searching for decays of the heavy scalar (H) and pseudo-scalar (A) Higgs bosons. These decays include the Standard Model-like Higgs h in the final state and lead to events with isolated leptons and photons. This search is carried out using a 19.5 fb−1 data sample at √s = 8 TeV collected by the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). Observed mul- tilepton events with or without diphoton candidates are organized into exclusive search channels based on event kinematics. The search channels are ordered by the amount of expected Standard Model background. Standard Model backgrounds are estimated using data-based techniques and data-validated simulations. The observed events are consistent with the Standard Model expectation. Limits are placed on the cross section of gluon-gluon fusion production of H and A. Exclusions of the Two Higgs Doublet Models (TYPE I and TYPE II) are presented in terms of the relevant parameters of the model.
Additional file 1: of Low uptake of Aboriginal interpreters in healthcare: exploration of current use in Australiaâ  s Northern Territory
Creators: name: Ralph, Anna
name: Lowell, Anne
name: Murphy, Jean
name: Dias, Tara
name: Butler, Deborah
name: Spain, Brian
name: Jaquelyne Hughes
name: Campbell, Lauren
name: Bauert, Barbara
name: Salter, Claire
name: Tune, Kylie
name: Cass, Alan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Hospital staff survey. (PDF 2.74 mb)
Damage identification, progression, and condition rating of bridge decks using multi-modal non-destructive testing
Creators: name: Pailes, Brian M.
Publisher: name: No Publisher Supplied
Year: 2014

description: Bridges are an important part of the nation’s infrastructure and due to the limited budgets available to keep them properly maintained, the methods of evaluation and damage identification must improve in accuracy and cost-effectiveness.  For the industry of bridge evaluation and damage identification the research area that provides the greatest potential is multi-modal non-destructive testing (NDT).  A multi-modal NDT approach to condition assessment allows for the identification of several different deterioration states, in turn providing a more complete condition assessment.  Research was conducted to develop a methodology and program to convert multi-modal NDT data from bare reinforced concrete bridge decks into a condition-based assessment.  The NDT methods utilized were electrical resistivity (ER), half-cell potential (HCP), ground penetrating radar (GPR), impact echo (IE), and chain drag (CD).  Data for each of these methods was collected on 12 bridge decks located in various geographic locations.  Correlations were identified between the NDT methods so as to better understand the relationship between the methods and concrete deterioration.  Some of the identified correlations include a strong association of low cover depth with deterioration, ER and HCP measurements being highly related, and GPR attenuation associated with locations of deterioration identify by ER, HCP, and CD.  The identified correlations were used to develop a statistics-based approach to threshold identification for ER, HCP, and GPR.  Threshold values are highly relative; therefore, a statistical approach provides a more effective and robust threshold identification methodology.  Using the identified thresholds, the multi-modal NDT data was fused and converted into a deterioration-based condition assessment that identifies locations of corrosive environment, active corrosion, delamination/lateral cracking, and severe delamination.  The condition assessment program also rates the bridge decks using established and federally mandated rating systems created by the National Bridge Inventory and American Association of State Highway and Transportation Officials.  This research resulted in a more effective multi-modal NDT condition assessment of bridge decks.  Improved multi-modal NDT will provide bridge owners and maintenance personnel an improved tool to assess bridge decks and to make decisions regarding their maintenance.
Hestiasula Saussure 1871
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Hestiasula

description: Hestiasula Saussure, 1871
= Hestias Saussure, 1872
= Catestiasula Giglio-Tos, 1915
Includes nineteen species in S and SE Asia. Forefemora enlarged, used in intraspecific communication and during startling display (“foreleg waving”, see MacKinnon 1969, Edmunds 1972, 1976, Loxton 1979, Schwarz 2003). Although listed here among Acromantinae, in concordance with Beier (1964) and Ehrmann (2002), molecular data suggest that this genus may be better placed among Oxypilinae (Svenson & Whiting 2009). This genus is arboricolous, although specimens can also be found on high weeds and scrubs.
Hestiasula phyllopus (De Haan, 1842)
Mantis (Oxypilus) phyllopus De Haan, 1842
= Hestias sarawaca Westwood, 1889
Distribution. Malay Peninsula, Sumatra, Mentawai Islands, Java, Borneo (Giglio-Tos 1927, Werner 1930, 1933, Ehrmann 2002).
Bornean records. Sarawak: Kuching (SMSM), Mt. Dulit (Beier 1937); Brunei: Kuala Belalong (OK in situ); Sabah: N Sabah (AFUW), Danum Valley (Helmkampf et al. 2007; CSUB)
Hestiasula sp.
Distribution. Borneo: Sarawak: Mt. Santubong (SMNK); Brunei: Kuala Belalong (OK in situ); Sabah: Danum Valley (Helmkampf et al. 2007).
Remarks. A second species closely related to H. phyllopus occurs in Borneo, distinguished from the latter by largely hyaline wings with an apical spot, and black fore-coxae. The taxonomic status of this species is currently under investigation by CS.
Hestiasula nitida (Brunner von Wattenwyl, 1892)
Pachymantis nitida Brunner von Wattenwyl, 1892
Distribution. N India, Myanmar, Sumatra, SE Borneo (Giglio-Tos 1927, Werner 1933, Beier 1958, Ehrmann 2002).
Bornean records. Kalimantan: Mentawir (Beier 1958), Sampit (Beier 1958).
Remarks. This and the following species are closely related. The tegmina are iridescent, hyaline with blackish veins. This species was placed in the genus Catestiasula by Giglio-Tos (1915), but united with Hestiasula by Beier (1934).
Hestiasula moultoni (Giglio-Tos, 1915)
Distribution. Borneo (Giglio-Tos 1915, 1927, Ehrmann 2002, Helmkampf et al. 2007). Sarawak: Kuching (Giglio-Tos 1927), Lanjak Entimau (1 m, CSUB); Brunei: Kuala Belalong (OK in situ); Sabah: Danum Valley (Helmkampf et al. 2007), Tawau Hills (AFUW).
Remarks. The tegmina are hyaline with reddish veins. This species was also placed in the genus Catestiasula by Giglio-Tos (1915).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on pages 139-140, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Carnivora Bowdich 1821
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora

description: Key to families of Carnivora in Korea
1 Limbs not modified; various tail lengths; carnassial well developed.............................................. 2
- Limbs modified to flippers; tail short; carnassials absent....................................................... 5
2 Tail longer than hind foot (except Lynx); last upper molar not the longest; shearing ridge or cusps present............... 3
- Tail shorter than 50% of hind foot length; last upper molar elongated anteroposteriorly (longest tooth); sharp shearing ridge or cusps absent on molars............................................................................ Ursidae
3 Front foot 5 toes; hind foot 4 toes......................................................................... 4
- All feet with 5 toes............................................................................ Mustelidae
4 Claws retractable................................................................................. Felidae
- Claws not retractable………………………………………………………..………………........ Canidae
5 Hind limbs rotated forward; pinnae small; postorbital process well developed……….............. Otariidae
- Hind limbs always point posteriorly; pinnae absent; postorbital process absent…..…………… Phocidae
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on pages 63-64, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Additional file 1: Table S1. of Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study-
Creators: name: Pavlicek, David
name: Krebs, Jörg
name: Capossela, Simona
name: Bertolo, Alessandro
name: Engelhardt, Britta
name: Pannek, Jürgen
name: Stoyanov, Jivko
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Alternative analysis of data to see the impact of SCI duration on the immune frailty parameters. The study participants were grouped according to the duration of SCI in the more recent (≤13.8 years with injury) and long-term (>13.8 years with injury) groups. Statistical significance was done with a Mann-Whitney U test. (PDF 228 kb)
Investigating impact of work zones on crash frequency, severity and traffic
Creators: name: Ozturk, Ozgur
Publisher: name: No Publisher Supplied
Year: 2014

description: Work zone presence is an important concern for drivers in terms of safety and congestion. In recent years, work zone safety has received much attention due to numerous highway renovation projects that have resulted in many work zone crashes. To minimize the effect of work zones on roadway safety risks and traffic conditions, potential factors need to be addressed and countermeasures need to be implemented to ensure that the motorist can drive in a safe manner.  The impact of the work zones can be estimated by using descriptive analysis and different statistical modeling methods. To this end, this study focused on three major areas: the crash frequency at work zones, the crash severity at work zones and the change in traffic conditions at work zones. Statistically robust models were developed by incorporating integrated datasets that could identify significant factors affecting each of these study areas. To better understand this, different from the previous studies, model results were compared against reference conditions, such as work zone crash frequency and modeling parameters were compared with non-work zone parameters. In addition, different statistical modeling techniques were applied to examine the best model or set of variables to connect crash severity and possible causative factors for binary level and multiple level outcomes. Two crash severity indexes were proposed and used to estimate multilevel crash severity by using both maximum severity and the monetary cost weighted severity. Besides safety issues, different types of lane closures and crashes observed within lane closures were studied to examine if there would be a change in traffic conditions compared with normal time traffic.  Comparisons of each concept provides an idea for agencies about the differences of work zone and non-work zone conditions which is important if indeed there is a specific impact for the work zone cases. Work zone presence was found to have an increasing effect on crash occurrence. Nighttime shifts were found to be safer when compared to daytime work zone periods. Injury crashes for two-lane closure cases were found to have a more marked impact on traffic volume compared with other cases studied in this dissertation. In the conclusions chapter, all of these findings are summarized along with specific recommendations.
Single-Molecule Studies of HIV-1 Rev-RRE Interactions
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV/AIDS continues to be a major health problem. The current generation of anti-HIV drugs target viral enzymes, but their efficacy is compromised by the ability of the virus to rapidly mutate and become resistant to the drugs. A promising alternative strategy is to target proteins of the host cell that are essential for viral replication but are less prone to mutation. This proposal focuses on host proteins that interact with the HIV-1 Rev protein and it’s cognate RNA, the Rev Responsive Element (RRE). The goal of the research proposed here is to understand how two host proteins, the DEAD box protein DDX1 and the transport protein CRM1, contribute to Rev function. The Rev protein (Regulator of Expression of Virion proteins) mediates the export of unspliced and singly spliced viral mRNA transcripts from the nucleus to the cytoplasm of an infected cell. The unspliced RNA encodes the viral RNA genome and the genes encoding viral structural proteins. Since the structural proteins and RNA genome are both needed to form new viral particles, the RNA export activity of Rev is a key step in the viral replication cycle. To promote nuclear export, Rev must bind to and oligomerize on the RRE, a conserved element found in unspliced and singly spliced viral RNA transcripts. Rev must also recruit CRM1 to form a functional export complex. DDX1 also enhances Rev-mediated export of unspliced and partially spliced transcripts and is essential for efficient viral replication. One goal of this project is to understand in mechanistic detail how DDX1 promotes oligomerization of Rev on the RRE. Another goal is to determine how CRM1 is recruited to the Rev-RRE complex and how many CRM1 molecules are incorporated. To answer these questions, novel fluorescence spectroscopic methods will be used to visualize Rev and DDX1 (or Rev and CRM1) assembling together on the same RRE molecule, under defined conditions in vitro. New methods will also be developed to observe the Rev-RRE-host complexes within mammalian cells and to determine their stoichiometry before and after export from the nucleus to the cytoplasm. The performance of these studies will be enhanced through interactions with the CHEETAH center (Cellular Host Elements in Egress, Trafficking and Assembly of HIV), an interdisciplinary center devoted to the study of HIV-host interactions. The project will fill a gap in our knowledge of Rev biology by revealing how specific host proteins contribute to Rev function by promoting formation of the Rev-RRE nuclear export complex. This new information will lead to a detailed picture of the entire assembly pathway, which should ultimately help in the design of small molecules that interfere with specific steps in the pathway and thereby inhibit HIV-1 replication.
Odontomantis Saussure 1871
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Odontomantis

description: Odontomantis Saussure, 1871
= Antissa Stål, 1871
There are sixteen species of this genus in S and SE Asia. They are arboricolous, but also found also on high weeds and scrubs. Nymphs resort to ant mimicry.
Odontomantis planiceps (De Haan, 1842) §
Mantis (Oxypilus) planiceps De Haan, 1842 (f)
= Acromantis javana Saussure, 1870
Distribution. Sumatra, Mentawai Islands (Sipora), Java, Borneo, Palawan (Hebard 1920, Giglio-Tos 1927, Ehrmann 2002).
Bornean records. Sarawak: Kuching (SMSM), Mt. Matang (SMSM), Klingkang (SMSM), Mt. Santubong (SMSM); Sabah: Sandakan (Hebard 1920), Labuan Island (Hebard 1920), Sorinsim (AFUW); Kalimantan: Long Petak (Werner 1933).
Odontomantis micantula Beier, 1956
Odontomantis (Euantissa) micantula Beier, 1956
Distribution. Sunda Islands, Mentawai Islands (Beier 1956).
Bornean records. Sarawak: Marudi (SMNK), Mt. Dulit (Beier 1937), Mt. Tibang (Werner 1930); Sabah: Crocker Range (AFUW), Mesilau (AFUW).
Remarks. According to Beier (1956), this species was confused by previous authors with the Ceylonese O. micans (Saussure, 1871); he proposed the name O. micantula for the Sunda species but without type designation. Taxonomic rearrangement not considered by Ehrmann (2002) and Otte & Spearman (2005).
Odontomantis rhyssa Werner, 1930
Distribution. Sarawak: Mt. Dulit (Beier 1937).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on pages 140-141, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Ursidae Fischer 1817
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Ursidae

description: Family URSIDAE Fischer, 1817
The Family Ursidae contains two species of the Genus Ursus in Korea. While Ursus thibetanus occurs throughout Korea, a northern species, U. arctos, has limited occupancy in areas north of Mt. Geumgang, despite a Pleistocene fossil record (12,500 yrs BP) in southern Korea. Both species have experienced excessive hunting pressures for gall bladders.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 64, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Anaxarcha Stal 1877
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Anaxarcha

description: Anaxarcha Stål, 1877
= Anaxandra Kirby, 1904 (er r. des cr.)
= Parastatilia Werner, 1922
Related to Odontomantis, despite its long and slender pronotum (Svenson & Whiting 2009). One of the seven known species occurs with certainty in Borneo. Like related taxa, this genus is arboricolous.
Anaxarcha limbata Giglio-Tos, 1915
= Oligomantis parallela Werner, 1930
Distribution. Malay Peninsula, Sumatra, Borneo (Giglio-Tos 1915a, Werner 1930, Beier 1931a, 1937, Ehrmann 2002).
Bornean records. Sarawak: Mt. Dulit (Werner 1930; Beier 1937); Kalimantan: Petak (Werner 1933).
Remarks. Beier (1931a) considered this species to be a synonym of A. graminea; some years later, however, he treated it as valid again (Beier 1937). The 1931 synonymization let Werner (1933) treat his Oligomantis parallela as a synonym of A. graminea. Records of A. graminea south of the Isthmus of Kraa have to be reevaluated.
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 141, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Dicyrtomellus simulans
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Dicyrtomellus
Dicyrtomellus simulans

description: Dicyrtomellus simulans (Priesner, 1955)
Distribution in the Arabian Peninsula: Saudi Arabia (Gadallah & El-Barty 2011).
Extralimital distribution: North and Central Africa to Central Asia (Priesner 1955).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 161, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Ursus Linnaeus 1758
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Ursidae
Ursus

description: Genus Ursus Linnaeus, 1758
Among the four species of Ursus, two species inhabit Korea. While U. arctos inhabited northeastern Korea, U. thibetanus became dispersed over the country. Currently, both species have an endangered status.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 65, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Targeting DNA repair function of breast cancer stem cells.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Recurrence and treatment-resistant metastasis are the major cause of mortality in breast cancer patients. According to the cancer stem cell theory, a rare breast cancer stem cell population drives tumor growth and metastasis. It is critical to eradicate breast cancer stem cells for successful treatment. Current studies suggest that breast cancer stem cells or tumor initiating cells are more resistant to chemotherapy drugs and radiation by virtue of elevated repair capacity. Therefore, modulation of DNA damage response network to minimize repair function of breast cancer stem cells can potentially sensitize these cells to chemotherapy drugs and radiation.

 The unique mechanisms of DNA repair pathways of breast cancer stem cells are unknown. In our first aim, we propose to use our breast cancer stem cell-based model and assay systems to identify targets in the DNA repair pathways that can be used to sensitize breast cancer stem cells to chemotherapy and radiotherapy. For these studies, we will use a high-throughput method adapted for breast cancer stem cells to screen a human RNA interference (RNAi) library and identify targets, which are suitable for drug design and development in the future. Our second aim is to test the effect of histone deacetylase (HDAC) inhibitors in sensitizing breast cancer stem cells to chemotherapy drugs and radiation. For these studies we will evaluate the efficacy of HDAC inhibitors to sensitize breast cancer stem cells to chemotherapy drugs and radiation using both cell-culture and animal models.

 Compromising DNA repair ability may be an effective way to reverse the resistance of breast cancer stem cells to chemo- and radiation therapy. If promising HDAC inhibitors are identified, they will be used in new clinical trials for breast cancer treatments. In addition, our proposed high throughput screening and assays can be adapted to other studies to advance breast cancer stem cell research.
Perversions of love
Creators: name: Patrón, Sebastián
Publisher: name: No Publisher Supplied
Year: 2014

description: In this dissertation I analyze the ways in which the narratives of António Lobo Antunes, Pepetela and Fernando Vallejo reveal the complicity between love and power. From their different socio-historical contexts, these writers disclose the contradictions besieging what Western culture has deemed to be the most positive of feelings. Regarded as an always-reciprocal and harmonious state where all contradictions between opposites are resolved in favor of a greater unity, love’s sphere of influence oftentimes extends beyond the intimate relationship between lover and beloved. Indeed, love’s ability to do away with discord has been repeatedly invoked in the political arena as a discursive means of resolving deeply entrenched social differences. Despite its discursive appeal, such an unequivocal approach to affect is not without its dangers, proving to be misleading when it comes to gauging the complex range of love’s political uses. As the narratives of António Lobo Antunes, Pepetela and Fernando Vallejo stress, depending on the specificity of context, the same love narratives can be used to support different, and sometimes diverging, political discourses. While António Lobo Antunes exposes how love was used both to justify and veil the violence the Portuguese State inflicted on colonial subjects from the second half of the twentieth century, Pepetela uses this same rhetoric as a way to cement the burgeoning Angolan nation and to counter Capitalism’s perverse logic of exchange. In conflict-ridden Colombia of the twentieth century, Fernando Vallejo’s vitriolic post-national discourse offers a stark contrast to the national romances of the nineteenth century. Rather than being an allegorical device that brings together all parties, for Vallejo the aggressiveness contained within love serves as a means of disrupting the Colombian elite’s failed national project. By thinking through love’s contradictions, these three writers debunk traditional love narratives. In so doing, they direct our attention to the concrete possibilities and pitfalls that love introduces into the political realm.
Ambivia Stal 1877
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Mantidae
Ambivia

description: Ambivia Stål, 1877
Oriental genus of short-bodied, stick-mimicking mantids with a history of unstable systematic placement. Most authors assigned it to Acromantinae, in its current definition (e. g. Stål 1877, Westwood 1889, Brunner von Wattenwyl 1892, Giglio-Tos 1915a, 1919, 1927, Werner 1922a, 1927, 1933, Wang 1993, Mukherjee et al. 1995), but it was regarded as a member of Mantidae (exclusive Vatidae) by Lombardo (1995), until it found its current placement alongside Popa Stål, 1856 within Mantidae Vatinae in Ehrmann (2002) and Otte & Spearman (2005). However, the molecular phylogeny of Svenson & Whiting (2009) corroborated its original systematic position among Acromantinae. Arboricolous.
Ambivia undata (Fabricius, 1793) §
Mantis undata Fabricius, 1793
= Ambivia popa Stål, 1877
Distribution. E India, Sri Lanka, Nepal, Myanmar, Vietnam, Thailand, Malay Peninsula, Sumatra, Borneo (Werner 1922, Giglio-Tos 1927, Beier 1956, Lombardo 1993, Ehrmann 2002). Bornean records. Sarawak: Mt. Matang (Giglio-Tos 1915a); Kalimantan: Sambas (Werner 1922).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 141, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Combating Breast Cancer with the Wellderly Immune Repertoire
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The “Wellderly” are a group of 1000 healthy people in their eighties who never had cancer or any other chronic disease. Our idea is that many of these people have a strong immune system, and that some may have had developing breast cancer cells in their bodies, at some point in time, but successfully produced antibodies that prevented tumor establishment. Our project will tap into the genes of the “Wellderly” and generate a “library” from their immune cells. This library will then be used to fish out antibodies that can inhibit breast cancer cells, particularly those that cause inflammatory breast cancer, the most aggressive form of this disease.

 For this project we have established a new breast cancer cell model that includes cell lines from the primary tumor, a local recurrence and a pleural effusion that developed despite chemotherapy and radiation in a young patient with very rapidly progressing inflammatory breast cancer. We will use this new model to address the following questions:

 1) Can we identify and isolate antibodies from the Wellderly immune repertoire that inhibit the growth of the aggressive breast cancer cells in culture and tumor development caused by these cells in experimental mice?

 2) What are the molecules that these antibodies recognize on the tumor cells, and can we learn from this information how aggressive breast cancer works?

 3) How do the tumor cells change while the patient is being treated with chemo and radiation, and what makes the tumor cells survive and escape the therapy?

 Our approach is to ‘mine’ the antibody library from the “Welldely” population by first removing antibodies that react with normal breast tissue. Then, we will pull out antibodies that specifically react with the aggressive breast cancer cells. Antibodies that bind to the tumor cells will be tested in culture, to see if they can inhibit tumor cell growth. Promising antibodies will be tested in mice that bear tumors from injecting the human breast cancer cells, to measure if this antibody treatment can stop tumor growth and spreading. Finding out which molecules such antibodies recognize on the tumor cells will help us understand how the cancer cells grow, produce tumors and spread the disease. Finally, we will analyze the gene expression profiles of the breast cancer cells from the primary tumor and the cells that caused the relapse and rapid cancer progression in the patient, even though she had various types of chemotherapy and radiation treatment.

 Human antibodies from the “Wellderly” might be directly used in patients or could be optimized for efficient therapy and combination treatments.