cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Facilitating active learning with international students: what worked and what didn't
Creators: name: Qian, David
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 3904
subject: Specialist studies in education

description: This paper explores the efficacy of applying active learning methods in tutorials for international students. First it looks at the way that tutorials were being conducted and discusses their inadequacies and the need for change. The paper then describes some of the different activities that were used to involve the students in a more active form of learning. The positive feeling of the tutor regarding the change was confirmed by the feedback from the students to a questionnaire. The paper argues that despite the language difficulties and a tradition of rote learning, international students respond more readily to a variety of more interactive practices, but this cannot happen unless the tutor is prepared to make greater efforts to plan more innovative activities.
Acculturation and management control: 'Japanese soul in Sri Lankan physique'
Creators: name: Hewege, Chandana
Publisher: name: Swinburne
Year: 2024

description: The study explores the way in which acculturation can be used as a management control mechanism. Acculturation---inculcating values and norms of one culture to another culture---has been studied in relation to national cultures whereas, the application of acculturation to the study area of management control is novel. By using the ethnographic research method, this research examines as to how a Sri Lankan subsidiary of a Japanese company acculturates its employees to Japanese work values with a view to instituting a positive work culture. The study has illustrated the process through which workers unlearned indigenous Sri Lankan work values and assimilated new Japanese work values. The findings are useful for designing strategies to acculturate employees to create an effective management control regime.
Anatomical and functional outcomes of prophylactic laser of choroidal coloboma
Creators: name: Tripathy, Koushik
name: Yog Raj Sharma
name: Singh, Harsh Inder
name: Subodh Kumar Singh
name: Venkatesh, Pradeep
name: Rajpal Vohra
name: Varun Gogia
name: Bypareddy, Ravi
name: Babulal Kumawat
Publisher: name: figshare
Year: 2015
Subjects: Medicine
Diseases

description: Anatomical and functional outcomes of prophylactic laser of choroidal coloboma.Koushik Tripathy, Yog Raj Sharma, Harsh Inder Singh, Subodh Kumar Singh, Pradeep Venkatesh, Rajpal Vohra, Varun Gogia, Ravi Bypareddy, Babulal Kumawat46th Annual Scientific Congress of The Royal Australian and New Zealand College of Ophthalmologists to be held at the Brisbane Convention and Exhibition Centre Brisbane, Australia on 22 to 26 November 2014 2014-11 | conference-poster - See more at: https://orcid.org/my-orcid#sthash.c1sXoqNm.dpuf
Mathematical e-learning
Creators: name: Juan, Angel A.
name: Huertas, Maria Antonia
name: Cuypers, Hans
name: Loch, Birgit
Publisher: name: Swinburne
Year: 2024

description: Educational technologies are changing the way in which higher education is delivered. These technologies include, but are not limited to, e-learning environments or learning management systems for individual and collaborative learning, Internet resources for teaching and learning, academic materials in electronic format, specific subject-related software, groupware and social networking software. With ubiquitous access to technology and technological innovation, over the last decades not only have we seen the establishment and growth of purely online universities, but we are also now witnessing a transformation in how instruction is being delivered in most traditional face-to-face universities. This transformation is affecting the nature of the courses as well as the degree programs offered by higher-education systems in a global world. These technological innovations have driven the growth of distance-learning opportunities, as students who are time bound---due to job or travel difficulties---or place bound---due to geographic location or physical disabilities---now have the flexibility to access courses and degree programs at their convenience.
A case study on providing international students the opportunity to enhance performance through online engagement
Creators: name: Gill, Robert
name: Verezub, Elena
name: Wang, Xi
Publisher: name: Swinburne
Year: 2024

description: International students who come from non-English speaking backgrounds (NESB) and are new to Australian university study can struggle with understanding information that is delivered verbally, particularly when delivered under the traditional lecture/tutorial or didactic approach. This can be compounded by large class numbers and cohorts dominated by local students who have grown up using English as their first language. This paper examines results by NESB students from Chinese universities who have studied the core unit of Professional Communication Practice in 2010 and 2011. These students came to the Lilydale campus of Swinburne University of Technology to complete Bachelor degrees under a collaborative articulated pathway program. The majority of these students have come from limited English-speaking environments. The paper analyses their results and uses contemporary literature to form conclusions on cognitive capabilities for the cohort when studying this introductory unit on-campus. The student results and literature review demonstrate that these NESB cohorts of students performed better when comprehending and consolidating knowledge delivered through interactivity involving text, or text-based content for instruction. This is particularly evidenced by the improved results for the second wave of NESB Chinese students, who were exposed to heightened 'e-text based' transactional communication (based on a social media model), as opposed to a dominant 'in-class verbal discussion' mode of delivery.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 5 (249)]
Creators: name: Bertraminus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1394
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Bertraminus, Sohn des verstorbenen Ottebonus de Spalenciis, aus Colognola, wohnhaft beim burgus St. Stepani in Bergamo, verschenkt an die Brüder Salarius, Merulfus, Rogerius und Alexander, Söhne des verstorbenen Girardus de Lasalle, Ländereien. Es schließen sich weitere Rechtsakte an.
Repurposing glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of intestinal helminth infection
Creators: name: Macluskie, Jess
Publisher: name: Lancaster University
Year: 2025
Subjects: helminth
GLP-1
Trichuris
infection
Neglected tropical disease
Trichinella spiralis
organoid

description: Soil-transmitted helminth infections are neglected tropical diseases,
 afflicting over 1.5 billion people in developing countries. Children often
 endure the heaviest parasite burdens, suffering from malnutrition, stunted
 growth and cognitive impairment. The widespread use of anthelmintic drugs
 as preventative chemotherapy has accentuated low cure rates, high
 reinfection rates and increasing prevalence of anthelmintic-resistant
 species, particularly in Trichuris infection, highlighting an urgent need
 for novel treatments. Intestinal helminth infections are associated with
 changes in enteroendocrine cell (EEC) development and peptide hormone
 secretion. Furthermore, intraepithelial lymphocytes, found at the parasite
 intestinal barrier niche, have been shown to express receptors for the EEC
 derived incretin peptide hormone, glucagon-like peptide-1 (GLP-1).
 Recently GLP-1 receptor agonist (GLP-1rA) treatment has been shown to
 induce expulsion of a chronic low-dose Trichuris muris infection via the
 adaptive immune system and accelerated intestinal epithelial turnover.
 However, the effects of intestinal helminths on endogenous GLP-1 secretion
 are currently unknown. Furthermore, the efficacy of GLP-1rA treatment in
 individuals with high infection intensity, and against challenge
 infection, is yet to be investigated. A small intestinal organoid platform
 was used to investigate the effects of intestinal helminth antigen on
 GLP-1 secretion. The mouse model of human trichuriasis, Trichuris muris,
 was employed to investigate the potential for the GLP-1rA, lixisenatide to
 induce protective effects against challenge infection, and, via
 rIL-12-pretreatment, to investigate the efficacy of lixisenatide against a
 chronic high-dose infection. Trichinella spiralis was shown to increase
 GLP-1 secretion from EECs in the small intestine through a mechanism
 mediated by bitter taste receptors. In vivo experimentation demonstrated
 that lixisenatide treatment drives a reduction in worm burden in a
 chronic, high-dose T. muris infection, and induces CD4+ T cell-mediated
 protection against challenge infection. These data provide further
 evidence that this treatment may provide an exciting novel option for the
 treatment of intestinal STH infection, with efficacy in reducing high
 intensity infection and providing some protection against reinfection,
 crucial effects that current anthelmintic treatments lack. GLP-1rAs are
 already approved for the treatment of type 2 diabetes mellitus and
 obesity, which would allow for rapid and straightforward repurposing of
 this drug class for the treatment of Trichuriasis afflicting livestock and
 humans worldwide.
Ergometrine stimulates histamine H2 receptors in the isolated human atrium
Creators: name: Jacob, Hannes
name: Braekow, Pauline
name: Hofmann, Britt
name: Kirchhefer, Uwe
name: Forster, Lisa
name: Mönnich, Denise
name: Humphrys, Laura J.
name: Pockes, Steffen
name: Neumann, Joachim
name: Gergs, Ulrich
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or ergonovine) activates several types of serotonin and histamine receptors in the animal heart. We thus examined whether ergometrine can activate human serotonin 5-HT4 receptors (h5-HT4R) and/or human histamine H2 receptors (hH2R) in the heart of transgenic mice and/or in the human isolated atrium. Force of contraction or beating rates were studied in electrically stimulated left atrial or spontaneously beating right atrial preparations or spontaneously beating isolated retrogradely perfused hearts (Langendorff setup) of mice with cardiac specific overexpression of the h5-HT4R (5-HT4-TG) or of mice with cardiac specific overexpression of the hH2R (H2-TG) or in electrically stimulated human right atrial preparations obtained during cardiac surgery. Western blots to assess phospholamban (PLB) phosphorylation on serine 16 were performed. Ergometrine exerted concentration- and time-dependent positive inotropic effects and positive chronotropic effects in atrial preparations starting at 0.3 µM and reaching a plateau at 10 µM in H2-TGs (n = 7). This was accompanied by an increase in PLB phosphorylation at serine 16. Ergometrine up 10 µM failed to increase force of contraction in left atrial preparations from 5-HT4-TGs (n = 5). Ten micrometer ergometrine increased the force of contraction in isolated retrogradely perfused spontaneously beating heart preparations (Langendorff setup) from H2-TG but not 5-HT4-TG. In the presence of the phosphodiesterase inhibitor cilostamide (1 µM), ergometrine at 10 µM exerted positive inotropic effects in isolated electrically stimulated human right atrial preparations, obtained during cardiac surgery, and these effects were eliminated by 10 µM of the H2R antagonist cimetidine but not by 10 µM of the 5-HT4R antagonist tropisetron. Furthermore, ergometrine showed binding to human histamine H2 receptors (at 100 µM and 1 mM) using HEK cells in a recombinant expression system (pKi < 4.5, n = 3). In conclusion, we suggest that ergometrine is an agonist at cardiac human H2Rs.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 7 (172)]
Creators: name: De Clarischis, Antonia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1498
Subjects: subject: Sonstige weltliche Aussteller
subject: Inventar
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Antonia de Clarischis aus der Nachbarschaft St. Leonardi in Cremona, Tochter des Johannes Antonius sowie Mutter und Vormund des Johannes Andreas, seinerseits Sohn und Erbe des verstorbenen Magisters Johannes de Taynis, legt ein Inventar der Güter ihres Mündels an.
Effect of steam curing on pasting and textural properties, starch structure and the quality of a local aromatic rice variety
Creators: name: Hasanniaa,, Farzaneh
name: Tajaddodi Talab, Kobra
name: Shahidi, Seyed-Ahmad
name: Ghorbani-Hasansaraei, Azade
Publisher: name: figshare
Year: 2022
Subjects: subject: 90805 Food Processing
subject: FOS: Other engineering and technologies

description: Steam curing is a process that is used to improve the quality of freshly harvested rice in the shortest time. The purpose of this study was to evaluate the effects of IMC and steaming time on the marketability of rice. The results indicate positive and more impressive effects of prolonged steaming (30 minutes) on HRP, grain hardness and elongation in the sample with IMC of 20% (w.b) compared with the sample with IMC of 17% (w.b). The results also showed a decreased peak (PV) and breakdown (BD) viscosity in both IMC. The highest decrease was observed in the samples that were steamed for 30 min. The results of scanning electron microscopy (SEM) revealed that the steaming of paddy for 30 min could not create a completely smooth surface in the grain. These observations indicate the inadequacy and uneven distribution of moisture for complete gelatinization even in grains with higher IMC.
title: Carotte :
title: Principes directeurs pour la conduite de l’examen de la distinction, de l’homogénéité et de la stabilité.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2023

description: Ces principes directeurs (“principes directeurs d’examen”) visent à approfondir les principes énoncés dans l’introduction générale (document TG/1/3) et dans les documents TGP qui s’y rapportent afin de donner des indications concrètes détaillées pour l’harmonisation de l’examen de la distinction, de l’homogénéité et de la stabilité (DHS) et, en particulier, à identifier des caractères convenant à l’examen DHS et à la production de descriptions variétales harmonisées.
From hansom cabs to harbour raves: a history of the city in Australian crime fiction
Creators: name: Beasley, Carolyn
Publisher: name: Swinburne
Year: 2024

description: The city has long been the dominant setting of the Australian crime novel. The representations of this setting, however, are under constant change and the city has evolved from the image of a distant stranger, to a threatening character in its own right, and finally to a themed space that connects body and landscape. This paper maps the evolution of the way cities are integrated and characterised in Australian crime fiction from the days of colonisation to modern times, discussing the work of colonial writer Fergus Hume, the retro-historical 1920s fiction of Kerry Greenwood, the 1980s Sydney-based work of Marele Day, and the contemporary Melbourne-centred work of Peter Temple, amongst others. It draws on John Wylie’s theories of landscape, Gaston Bachelard's explorations into the notion of space, and the competing interpretations of the city dweller proposed by Robert Park and John Irwin.
Cation substitution in synthetic meridianiite (MgSO4·11D2O): phase behaviour and changes in unit-cell parameters
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Knight, Kevin
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report. Describes work to synthesise novel 8- and 9-hydrates of nickel sulfate by rapid quenching of aqueous solutions (D2O) in liquid nitrogen.
Understanding the rights of nature : working together across and beyond disciplines
Creators: name: Gilbert, Jérémie
name: Soliev, Ilkhom
name: Robertson, Anne
name: Vermeylen, Saskia
name: Williams, Neil W.
name: Grabowski, Robert C.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 577

description: Recognising the rights of nature is seen by many as the paradigm shift needed to truly embed ecology and the environment into nature-based policy and management solutions to address biodiversity loss, climate change, and sustainable development. However, despite its potential, research across and beyond disciplinary boundaries remains very limited, with most located in the humanities and social sciences and often lacking connection with environmental sciences. Based on a multi-, inter-, and transdisciplinary project, we identify some critical common themes among the humanities, social sciences, and environmental sciences to support future research on the potential of the rights of nature to address contemporary social-environmental challenges. We argue that future research needs to be not only interdisciplinary but also transdisciplinary since the movement of rights of nature is often driven by and based on knowledge emerging outside of academic disciplines.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 4 (28)]
Creators: name: Sexena
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1304
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Sexena de Zurlis, Äbtissin des Klosters St. Redegondae in Mailand, investiert mit Zustimmung des Konvents den Philippus, Sohn des verstorbenen Guillelmus Cuba, und seinen Sohn Jacobinus mit Gütern in Overnago.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 4 (41 a)]
Creators: name: Bartolomeus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1309
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Bartolomeus de Parma, Abt des Klosters von Civate, und weitere Geistliche des Klosters belehnen Johannes de la Cauate mit einem Gartengrundstück, gelegen im burgus von Civate an einem Ort, genannt in brolio.
OR-1896 increases force of contraction in the isolated human atrium
Creators: name: Rayo-Abella, Lina M.
name: Grundig, Peter
name: Bernhardt, Max N.
name: Hofmann, Britt
name: Neumann, Joachim
name: Gergs, Ulrich
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: OR-1896 ((R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide) is the main active metabolite of levosimendan. However, nobody has reported a positive inotropic effect of OR-1896 in isolated human cardiac preparations. The mechanism of action of OR-1896 remains controversial. Hence, we wanted to know whether OR-1896 exerts a positive inotropic effect in humans and what might be the underlying mechanism. Therefore, we measured the contractile effects of OR-1896 (0.01–10 µM cumulatively applied) in isolated electrically stimulated (1 Hz) human right atrial preparations (HAP) obtained during cardiac surgery. OR-1896, given alone, exerted time- and concentration-dependent positive inotropic effects; 1-µM OR-1896 increased force by 72 ± 14.7% (p < 0.05, n = 6) and shortened the time of relaxation by 10.6 ± 3.6% (p < 0.05, n = 11) in HAP started at 0.1 µM, plateaued at 1-µM OR-1896, and was antagonized by 1-µM propranolol. The maximum positive inotropic effect of OR-1896 in human right atrial preparations was less than that of 10-µM isoprenaline. EMD 57033 (10 µM), a calcium sensitizer, enhanced the force of contraction further in the additional presence of 1-µM OR-1896 by 109 ± 19% (p < 0.05, n = 4). Cilostamide (10 µM), an inhibitor of phosphodiesterase III given before OR-1896 (1 µM), blocked the positive inotropic effect of OR-1896 in HAP. Our data suggest that OR-1896 is, indeed, a positive inotropic agent in the human heart. OR-1896 acts as a PDE III inhibitor. OR-1896 is unlikely to act as a calcium sensitizer in the human heart.
Intention to undergo clinical breast examination and its associated factors among women attending rural primary healthcare facilities in South Central Ethiopia
Creators: name: Ketemaa, Bezawit
name: Kabaa, Mirgissa
name: Negash, Sarah
name: Addissiea, Adamu
name: Kantelhardt, Eva Johanna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Breast cancer is a global public health problem with higher mortality in developing countries. The Ethiopian National Cancer Control Plan recommends clinical breast examination (CBE) for all women aged >18 years. However, there is low breast examination practice in Ethiopia. Therefore, this study aimed to describe level of intention to undergo CBE and associated factors among women visited selected rural healthcare facilities in south central Ethiopia using Theory of Planned Behavior (TPB). Methods: This study used facility-based cross-sectional study design. A total of 420 women participated in this study. Interviewer-administered structured questionnaire was adopted from previously published research works and Ajzen’s TPB manual. Statistical Package for Social Sciences (SPSS), version 27, was used for analysis. Binary logistic regression model was used to determine factors associated with intention to undergo CBE. Results: In this study, nine out of ten women had never had CBE. Mean score for intention to undergo CBE was 12.55 (SD ± 3.22; min 5, max 20). Intention to undergo CBE was negatively associated with being in the second and middle wealth quantiles compared to the highest wealth quantile, and with the spouse not being able to read or write compared to having attended formal education. Positive attitude and higher subjective norm had relevant association with intention to undergo CBE. Conclusion: The high score for intention to undergo CBE should encourage primary healthcare facilities to offer CBE. Behavioral change communication interventions could address women’s attitude, subjective norm, and spouse’s education associated with intention to undergo CBE.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 4 (34)]
Creators: name: Malgarita
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1307
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Die Priorin Malgarita de Nouaria und weitere genannte Geistliche des Nonnenklosters St. Redegondae in Mailand legen Widerpruch dagegen ein, dass Rugerius Sechapanis, Bruder des Sechapanis de Sechapanibus und Sohn des verstorbenen Jacobus de Sechapanis, verbindlich erklärt hat, alle seine Güter dem Obizo Zuchalla als Pfand zu geben. Es schließen sich verschiedene Rechtsakte an.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 5 (236)]
Creators: name: Merolfus
name: Guillelmus
name: Guardinus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1392
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Merolfus, Sohn des verstorbenen Girardus de Lassalle, aus Bergamo in seinem und im Namen seiner Brüder Rogerius und Alexander, ebenfalls Söhne des genannten Girardus, als erste Partei sowie Guillelmus, Sohn des verstorbenen Gisinus de Ficienis, aus Bergamo als zweite und Guardinus, Sohn des verstorbenen Petinus, seinerseits einst genannt Guidottus de Ficienis, ebenfalls aus Bergamo, als dritte Partei wählen den Henrichus, Sohn des miles Guillelmus de Suardis, aus Bergamo zu ihrem Schiedsrichter in einem Streit um Land, gelegen in Monticelli di Borgogna im disctrictus von Bergamo. Es schließt sich ein weiterer Rechtsakt an, in dem Henrichus den beiden ersten Parteien den Landbesitz zuspricht und die dritte mit einem Geldbetrag abfindet.
Lysergic acid diethylamide stimulates cardiac human H2 histamine and cardiac human 5-HT4-serotonin receptors
Creators: name: Gergs, Ulrich
name: Jacob, Hannes
name: Braekow, Pauline
name: Hofmann, Britt
name: Pockes, Steffen
name: Humphrys, Laura J.
name: Kirchhefer, Uwe
name: Fehse, Charlotte
name: Neumann, Joachim
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors. We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice with cardiomyocyte-specific overexpression of the human 5-HT4 receptor (5-HT4-TG) or of the H2-histamine receptor (H2-TG). For comparison, we used wild type littermate mice (WT). Finally, we measured isometric force of contraction in isolated electrically stimulated muscle strips from the human right atrium obtained from patients during bypass surgery. LSD (up to 10 µM) concentration dependently increased force of contraction and beating rate in left or right atrial preparations from 5-HT4-TG (n = 6, p < 0.05) in 5-HT4-TG atrial preparations. The inotropic and chronotropic effects of LSD were antagonized by 10 µM tropisetron in 5-HT4-TG. In contrast, LSD (10 µM) increased force of contraction and beating rate in left or right atrial preparations, from H2-TG. After pre-stimulation with cilostamide (1 µM), LSD (10 µM) increased force of contraction in human atrial preparations (n = 6, p < 0.05). The contractile effects of LSD in human atrial preparations could be antagonized by 10 µM cimetidine and 1 µM GR 125487. LSD leads to H2-histamine receptor and 5-HT4-receptor mediated cardiac effects in humans.
The nephrotoxin ochratoxin a impairs resilience of energy homeostasis of human proximal tubule cells
Creators: name: Schwerdt, Gerald
name: Kopf, Michael
name: Gekle, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Despite a long history of research, the mode of action of the mycotoxin ochratoxin A (OTA) is still not clear. Based on our observation that OTA-exposed cells consume more glucose and produce more lactate than control cells, with this study, we want to suggest another possible mode of action of OTA, involving cellular metabolism and mitochondria. We exposed human proximal tubule cells (HK2 cells) to OTA and studied its influence on mitochondrial performance as well as on the expression of energy homeostasis-involved routing proteins (AMPK and TXNIP) and on glucose transporting and metabolizing proteins. OTA reduced the capacity of mitochondria to increase their oxygen consumption rate forcing the cells to switch to the ineffective anaerobic glycolysis which demands higher glucose availability. The higher glucose demand is met by augmented cellular glycogen degradation and increased glucose uptake capabilities by increasing glucose transporter expression. We conclude that OTA exposure leads to impaired mitochondria, which forces the cells to alter their metabolism in order to ensure energy supply. We suggest to consider a possible effect of OTA on metabolism and mitochondria and to have a closer look on OTA-induced changes in the metabolome as possible additional players in OTA toxicity.
Clarifying food education toward innovation and design for the global green new deal
Creators: name: Turner, Alan
name: Seemann, Kurt
Publisher: name: Swinburne
Year: 2024

description: There is an increasing need for food and beverage industries to develop a culture of innovation and sustainability around food practices. The increase in world population and demands of consumers contribute to the development of a diverse suite of food capabilities, and remains a significant issue in relation to climate change and staff education. For businesses it is important to develop new concepts and processes that combine purpose and contextual factors in association with sustainability knowledge and the choice of food hospitality tools, techniques, and materials for meal design. Technacy genre theory is explored as a framework applicable to the level of kitchen systems and skills that allows for sustainable and effective understandings of technological practice and innovation for a range of green new deal hospitality capabilities.
Behaviour of hexamethylenetetramine hexahydrate to 5 GPa
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Tucker, Matthew
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report. Describes compression of hexamethylenetetramine hexahydrate (perdeuterated) to obtain information on compressibility and high-pressure phase transformations.
Equation of state of ice VI
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Tucker, Matthew
Publisher: name: figshare
Year: 2015
Subjects: Crystallography
Planetary Science
Mineralogy

description: ISIS spallation neutron source experimental report. Describes work down to determine the P-V-T equation of state of deuterated ice VI throughout its P-T stability field.
Tree diversity effects on litter decomposition are mediated by litterfall and microbial processes
Creators: name: Beugnon, Rémy
name: Eisenhauer, Nico
name: Bruelheide, Helge
name: Davrinche, Andréa Marie
name: Du, Jianqing
name: Haider, Sylvia Simone Rebekka
name: Hähn, Georg
name: Saadani, Mariem
name: Singavarapu, Bala
name: Sünnemann, Marie
name: Thouvenot, Lise
name: Wang, Yanfen
name: Tesfaye Wubet
name: Xue, Kai
name: Cesarz, Simone
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 580

description: Forest ecosystems are critical for their carbon sequestration potential. Increasing tree diversity has been shown to enhance both forest productivity and litter decomposition. Litter diversity increases litter decomposability by increasing the diversity of substrates offered to decomposers. However, the relative importance of litter decomposability and decomposer community in mediating tree diversity effects on decomposition remains unknown. Moreover, tree diversity modulation of litterfall spatial distribution, and consequently litter decomposition, has rarely been tested. We studied tree diversity effects on leaf litter decomposition and its mediation by the amount of litterfall, litter species richness and decomposability, and soil microorganisms in a large-scale tree diversity experiment in subtropical China. Furthermore, we examined how litter functional identity and diversity affect leaf litter decomposability. Finally, we tested how leaf functional traits, tree biomass, and forest spatial structure drive the litterfall spatial distribution. We found evidence that tree species richness increased litter decomposition by increasing litter species richness and the amount of litterfall. We showed that soil microorganisms in this subtropical forest perform 84–87% of litter decomposition. Moreover, changes in the amount of litterfall and microbial decomposition explained 19–37% of the decomposition variance. Additionally, up to 20% of the microbial decomposition variance was explained by litter decomposability, while litter decomposability itself was determined by litter functional identity, diversity, and species richness. Tree species richness increased litter species richness and the amount of litterfall (+200% from monoculture to eight-species neighborhood). We further demonstrated that the amount of species-specific litterfall increased with increasing tree proximity and biomass, and was modulated by leaf functional traits. These litterfall drivers increased the spatial heterogeneity of litter distribution, and thus litter decomposition. We highlighted multiple biomass- and diversity-mediated effects of tree diversity on ecosystem properties driving forest nutrient cycling. We conclude that considering spatial variability in biotic properties will improve our mechanistic understanding of ecosystem functioning.
Phase behaviour of methane clathrate under conditions relevant to Titan’s interior
Creators: name: Fortes, Andrew Dominic
name: Sclater, Gillian
name: Wood, Ian
name: Crawford, Ian
name: Tucker, Matthew
Publisher: name: figshare
Year: 2015
Subjects: Crystallography
Planetary Science
Mineralogy

description: ISIS spallation neutron source experimental report. Describes an initial high-pressure study of deuterated methane hydrate, examining the structure I - II - H phase transitions and the stability field of the orthorhombic dihydrate.
Cation substitution in synthetic meridianiite (MgSO4·11H2O): site distribution in CoSO4- and MnSO4-doped single crystals.
Creators: name: Fortes, Andrew Dominic
name: Gutmann, Matthias
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report. Describes work to determine the distribution of divalent Co and Mn ions in the structure of synthetic meridianiite using time-of-flight neutron Laue diffraction.
Thermoelastic properties and high-pressure decomposition of MgSO4·11D2O
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Fernandez-Alonso, Felix
Publisher: name: figshare
Year: 2015
Subjects: Crystallography
Planetary Science
Mineralogy

description: ISIS spallation neutron source experimental report. Describes a study of the isothermal equation of state of synthetic meridianiite (deuterated) up to 550 MPa and its subsequent decomposition on warming at high-pressure.
Thermal expansion and phase transition in magnesium sulfate trihydrate
Creators: name: Fortes, Andrew Dominic
name: Knight, Kevin
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report Describes a temperature-dependent high-resolution study of magnesium sulfate trihydrate (deuterated) to determine its thermal expansivity and to characterize the phase transition that occurs on cooling.
Recovery and characterisation of high-pressure phases in the systems H2O – NH3, H2O – H2SO4, and H2O – MgSO4.
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Sclater, Gillian
name: Tucker, Matthew
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report. Describes efforts to synthesise a range of new high-pressure phases in several aqueous systems.
Thermal expansion and simultaneous Raman spectroscopy of methanol ammoniates, CD3OD·ND3 and 2CD3OD·ND3
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Knight, Kevin
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report. Describes a continued study of liquid-nitrogen-quenched mixtures of methanol and ammonia to form ammoniate crystals. Examines the occurrence of a new metastable phase and characterizes the thermal expansion of several polymorphs.
Engaging students in cognitive and metacognitive processes using screencasts
Creators: name: McLoughlin, Christopher
name: Loch, Birgit
Publisher: name: Swinburne
Year: 2024

description: Interest has grown in recent years in what is sometimes referred to as the learner experience, because it situates learners at the centre of the experience, empowers and motivates them to assume responsibility for their own learning, and adopts teaching and learning strategies designed to encourage students to see themselves as active thinkers and problem-solvers. Learner-centred education may be facilitated by technology, for example through the provision of online learning material. Flexible, self paced delivery of learning resources has the capacity to engage students in both cognitive and metacognitive processing of abstract concepts, Examples will be drawn from a project that uses mathematical screen casts to assist student to learn abstract concepts independently.
Recovery and characterisation of high-pressure phases in the systems H2O – NH3, H2O – H2SO4, and H2O – MgSO4.
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Sclater, Gillian
name: Tucker, Matthew
Publisher: name: figshare
Year: 2015
Subjects: Crystallography

description: ISIS spallation neutron source experimental report. Describes efforts to measure neutron powder diffraction data from high-pressure phases recovered under liquid nitrogen.
Increasing social disparities in obesity among 15000 pre-schoolers in a German district from 2009 to 2019
Creators: name: Michel, Zora
name: Krayl, Nele
name: Götz, Katja
name: Wienke, Andreas
name: Mikolajczyk, Rafael
name: Führer, Amand-Gabriel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Although childhood obesity prevalence has stagnated in many high-income regions after decades of increase, it continues to be a major public health problem with adverse effects. The objective was to examine obesity trends as a function of parental social status to identify obesity disparities among children. Methods: Data from school entry examinations from 2009 to 2019 of 14 952 pre-schoolers in one German district were used. Logistic regression models (obesity/overweight as dependent variable) and a linear regression [BMI z-score (BMIz) as dependent variable] were performed adjusted for social status and sex to investigate time trends in overweight and obesity. Results: Overall, we found an increase of obesity over time [odds ratio (ORs): 1.03 per year, 95% CI: 1.01–1.06]. Children with low social status had an OR of 1.08 per year (95% CI: 1.03–1.13), while the trend was less expressed in children with high social status (OR: 1.03 per year, 95% CI: 0.98–1.08). The mean BMIz decreased per year (regression coefficient −0.005 per year, 95% CI: −0.01 to 0.0) when considering all children. This decrease was more pronounced in children with high social status (regression coefficient: −0.011 per year, 95% CI: −0.019 to −0.004), compared with a slight increase of 0.014 (95% CI: −0.003 to 0.03) per year among children with low social status. Also, children with low parental social status were heavier and smaller than their peers with high social status. Conclusions: Although the mean BMIz decreased among pre-schoolers, obesity prevalence and status-related inequity in obesity prevalence increased from 2009 to 2019 in the region studied.
Rheological properties of rock-ice mixtures
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Middleton, Ceri
name: Grindrod, Peter
name: Hunt, Simon
Publisher: name: figshare
Year: 2015
Subjects: Planetary Science
Mineralogy
Crystallography

description: ISIS spallation neutron source experimental report. Describes work to study strain partitioning in rock (fluorite) - ice mixtures using neutron powder diffraction methods.
title: The Anxiety of Prestige in Stephen King’s Stylistics
Creators: name: Ketzan, Erik
name: Eve, Martin Paul
Publisher: name: UNSPECIFIED
Year: 2024

description: This paper introduces a term, the anxiety of prestige, to examine
thematic or stylistic textual commentaries by generally considered “popular”
fiction authors on issues of literary prestige, with Stephen King as a case study.
While, thematically, an anxiety of prestige has been obvious in many of King’s
works for decades, we suggest a novel approach: unearthing latent evidence
of an anxiety of prestige in King’s stylistics, through corpus query of specific
stylistic features suggested by King’s own writing advice book, namely adverbs,
the passive voice, and “Swifties”. Through close and distant reading, we interpret
these stylistic features as evidence of King’s textual responses to perceptions
of “low” and “high” literature, and suggest that the anxiety of prestige can be
investigated in larger popular fiction corpora in future work.
On modeling query refinement by capturing user intent through feedback
Creators: name: Islam, Md. Saiful
name: Liu, Chengfei
name: Zhou, Rui
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 461305
subject: Data structures and algorithms

description: SQL queries in relational data model implement the binary satisfaction of tuples. Tuples are generally filtered out from the result set if they miss the constraints expressed in the predicates of the given query. For naive or inexperienced users posing precise queries in the first place is very difficult as they lack of knowledge of the underlying dataset. Therefore, imprecise queries are commonplace for them. In connection with it, users are interested to have explanation of the missing answers. Even for unexpected tuples present in the result set advanced users may also want to know why a particular piece of information is present in the result set. This paper presents a simple model for generating explanations for both unexpected and missing answers. Further, we show how these explanations can be used to capture the user intent via feedback specifically for refining initial imprecise queries. The presented framework can also be thought as a natural extension for the existing SQL queries where support of explanation of expected and unexpected results are required to enhance the usability of relational database management systems. Finally, we summarize future research directions and challenges that need to be addressed in this endeavour.
The phase transitions in epsomite (MgSO4.7D2O)
Creators: name: Fortes, Andrew Dominic
name: Wood, Ian
name: Tucker, Matthew
Publisher: name: figshare
Year: 2015
Subjects: Crystallography
Mineralogy

description: ISIS spallation neutron source experimental report. Describes the series of phase transitions observed on compression of deuterated magnesium sulfate heptahydrate, including a new polymorph with a quite narrow stability field (in P).
Evaluation of occupational factors influencing the experience of an autopsy demonstration
Creators: name: Panusch, Philipp
name: Heide, Steffen
name: Lessig, Rüdiger
name: Richter, Carolin
name: Stiller, Dankwart
name: Medenwald, Daniel
name: Schmidt, Uwe
name: Weber, Marko
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Autopsy demonstrations have been an integral part of medical school, medical and nonmedical education for many decades; however, a direct comparison of the experience of an autopsy demonstration of different groups of participants is missing so far. In this study, the experience of such a situation by the different professional groups was analyzed and discussed in order to improve future dissections for the participant groups. Methods: Evaluations of 54 autopsy demonstrations were performed at the Institute of Legal Medicine of the University Hospital Halle (Saale) and the branch office in Magdeburg in the period 2017–2020. A total of 794 questionnaires were answered and statistically analyzed. Participants rated the autopsies in various question categories and, if applicable, provided reasons for discontinuation of the demonstration on their part (e.g., circulatory dysregulation). To analyze the results the Kruskall Wallis test, the Mann-Whitney U-test and the χ2-test were applied. Results: Findings showed that the professional background has a significant influence on the experience and the dropout rates from an autopsy. Furthermore, the professional groups have different areas of interest and expectations of an autopsy. Conclusion: The results require customized preparation of an autopsy demonstration as well as differentiation of knowledge transfer to different groups of participants to optimize their benefit.
QUDDUSI SHARIFNI QAYTARIB OLGAN SULTON SALOHIDDIN AYYUBIY
Creators: name: Mamasoliyeva, Guldona
name: Rahimova, Ismigul
Publisher: name: Zenodo
Year: 2024

description: Ummat tarixida muhim o'rin tutadigan voqealardan biri — Salohiddin Ayyubiy tomonidan Quddusni qaytarib olishidir. Ushbu maqolada Sultan Salohiddin Ayyubiyning harbiy strategiyalari, diniy motivatsiyalari va Quddusni qaytarish jarayonidagi rolini tahlil qilinadi. Shuningdek, bu voqea musulmonlarning birligi va jahon tarixidagi o'rni ham ko'rib chiqiladi..
Who sets the standards in higher education?
Creators: name: Thompson-Whiteside, Scott
Publisher: name: Swinburne
Year: 2024

description: In view of recent legislation to introduce the Tertiary Education Quality and Standards Agency in Australia, greater emphasis is being placed on the notion of standards in higher education. A standards-based audit or assessment implies that institutions need to demonstrate performance or achievement against a set of explicit thresholds. This paper explores the question of whether these standards, as a set of demonstrable thresholds, will be set by institutions, by TEQSA or by some other means? How will these thresholds be determined and who has the authority to set them? The paper makes reference to international policy settings and presents a theoretical construct for standards in higher education. The paper concludes by suggesting how the setting of external national standards changes the locus of power and control away from institutions.
Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension
Creators: name: Wunder, Frank
name: Stasch, Johannes-Peter
name: Knorr, Andreas
name: Mondritzki, Thomas
name: Brockschnieder, Damian
name: Becker-Pelster, Eva-Maria
name: Sandner, Peter
name: Tinel, Hanna
name: Redlich, Gorden
name: Hartung, Ingo V.
name: Vakalopoulos, Alexandros
name: Follmann, Markus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 615

description: Background and Purpose: First-generation soluble guanylate cyclase (sGC) stimulators have shown clinical benefit in pulmonary hypertension (riociguat) and chronic heart failure (vericiguat). However, given the broad therapeutic opportunities for sGC stimulators, tailored molecules for distinct indications are required. Experimental Approach: We report the high-throughput screening (HTS)-based discovery of a second generation of sGC stimulators from a novel imidazo[1,2-a]pyridine lead series. An intense medicinal chemistry programme resulted in the discovery of the sGC stimulator BAY 1165747 (BAY-747). The pharmacokinetic profile of BAY-747 was determined in different species, and it was broadly characterized in pharmacological model systems relevant for vasodilatation and hypertension. Key Results: BAY-747 is a highly potent sGC stimulator in vitro. In addition, BAY-747 showed an excellent pharmacokinetic profile with long half-life and low peak-to-trough ratio. BAY-747 was investigated in experimental in vivo models of malignant and resistant hypertension (rHT). In spontaneously hypertensive (SH) rats, BAY-747 caused a dose-related and long-lasting decrease in mean arterial blood pressure (MAP). Oral treatment over 12 days resulted in a persistent decrease. BAY-747 provided additional benefit when dosed on top of losartan, amlodipine or spironolactone and even on top of triple combinations of frequently used antihypertensive drugs. In a new canine model of rHT, BAY-747 caused a dose-related and long-lasting (>6 h) MAP decrease. Conclusion and Implications: BAY-747 is a potent, orally available sGC stimulator. BAY-747 shows long-acting pharmacodynamic effects with a very low peak-to-trough ratio. BAY-747 could be a treatment alternative for patients with hypertension, especially those not responding to standard-of-care therapy.