title: Ð ÐµÐ°ÐºÑÐ¸Ñ Ð²ÐµÐ½Ð¾Ð·Ð½Ð¾Ð¹ ÐºÑÐ¾Ð²Ð¸ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð½Ð° ÐºÐ¾Ð½ÑÐ°ÐºÑ Ñ Ð³ÑÐ°Ð½ÑÐ»Ð°Ð¼Ð¸ ÐºÑÐµÐ¼Ð½ÐµÐ·ÐµÐ¼Ð½ÑÑ ÑÐ¾ÑÐ±ÐµÐ½ÑÐ¾Ð², Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÑÐ³Ð»ÐµÑÐ¾Ð´Ð½ÑÐ¼Ð¸ Ð½Ð°Ð½Ð¾ÑÑÑÐ±ÐºÐ°Ð¼Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Reaction of human venous blood to contact with granules of silica sorbents modified with carbon nanotubes
Creators: name: ÐÑÐ¸ÑÑÐº, ÐÐ²Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð¡Ð¾ÑÐ±ÐµÐ½ÑÑ
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ÑÐ³Ð»ÐµÑÐ¾Ð´Ð½ÑÐµ Ð½Ð°Ð½Ð¾ÑÑÑÐ±ÐºÐ¸
ÐºÐ¾Ð½ÑÐ°ÐºÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ñ ÐºÑÐ¾Ð²Ð¸
Ð³ÐµÐ¼Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ

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description: The aim of the work is to evaluate the activation capabilities of carbon nanotubes immobilized on silica gels for possible use in low-volume hemoperfusion (LVH). Two types of silica gels (coarse-grained silica gel, coarse-pored (CSC-2) and aerosil gel (AE)) were studied, as well as composite sorbents â carbon nanotubes (CNTs) immobilized on silica gel granules. The results were compared with the characteristics of the activated charcoal used in the LVH. CNTs are widely used in various spheres of life. Their interaction with cells is currently interesting and relevant, in particular by the development of new sorbents for LVH. The contact of the donor venous blood with the sorbents was carried out in the bench conditions. Blood samples were collected before the start of the blood-sorbent interaction, as well as 5, 20, 40 and 60 minutes after the start of the contact. During the first 20 minutes of contact, extremely low adhesion of red blood cells was observed. Platelets and white blood cells, as well as all white blood cell subpopulations, show the reversible adhesion to the studied sorbents. The rate of leukocyte adhesion is higher in composite sorbents compared to matrices, and also higher in CSC-2-based sorbents compared to AE-based sorbents. The studied sorbents cause significant hemolysis during long periods of contact with blood, and therefore modification of the materials is necessary for their possible introduction into the clinic. Composite sorbents caused less hemolysis compared to silica gel matrices.