cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells
Creators: name: Zucker, Robert M.
name: Chang, Christopher J.
name: Miller, Evan W.
name: Cheng, Wan-Yun
name: Bromberg, Philip A.
name: Samet, James M.
name: Remington, James
name: Hofer, Thomas P.J.
name: Tong, Haiyan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress resulting from mitochondrial dysfunction. Zinc is a common environmental metallic contaminant that has been implicated in a variety of oxidant-dependent toxicological responses. Unlike ions of other transition metals such as iron, copper, and vanadium, Zn2+ does not generate reactive oxygen species (ROS) through redox cycling.ObjectiveTo characterize the role of oxidative stress in zinc-induced toxicity.MethodsWe used an integrated imaging approach that employs the hydrogen peroxide (H2O2)-specific fluorophore Peroxy Green 1 (PG1), the mitochondrial potential sensor 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide (JC-1), and the mitochondria-targeted form of the redox-sensitive genetically encoded fluorophore MTroGFP1 in living cells.ResultsZinc treatment in the presence of the Zn2+ ionophore pyrithione of A431 skin carcinoma cells preloaded with the H2O2-specific indicator PG1 resulted in a significant increase in H2O2 production that could be significantly inhibited with the mitochondrial inhibitor carbonyl cyanide 3-chlorophenylhydrazone. Mitochondria were further implicated as the source of zinc-induced H2O2 formation by the observation that exposure to zinc caused a loss of mitochondrial membrane potential. Using MTroGFP1, we showed that zinc exposure of A431 cells induces a rapid loss of reducing redox potential in mitochondria. We also demonstrated that zinc exposure results in rapid swelling of mitochondria isolated from mouse hearts.ConclusionTaken together, these findings show a disruption of mitochondrial integrity, H2O2 formation, and a shift toward positive redox potential in cells exposed to zinc. These data demonstrate the utility of real-time, live-cell imaging to study the role of oxidative stress in toxicological responses.
Development of modularity in the neural activity of children's brains
Creators: name: Chen, Man
name: Deem, Michael W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: We study how modularity of the human brain changes as children develop into adults. Theory suggests that modularity can enhance the response function of a networked system subject to changing external stimuli. Thus, greater cognitive performance might be achieved for more modular neural activity, and modularity might likely increase as children develop. The value of modularity calculated from fMRI data is observed to increase during childhood development and peak in young adulthood. Head motion is deconvolved from the fMRI data, and it is shown that the dependence of modularity on age is independent of the magnitude of head motion. A model is presented to illustrate how modularity can provide greater cognitive performance at short times, i.e.\ task switching. A fitness function is extracted from the model. Quasispecies theory is used to predict how the average modularity evolves with age, illustrating the increase of modularity during development from children to adults that arises from selection for rapid cognitive function in young adults. Experiments exploring the effect of modularity on cognitive performance are suggested. Modularity may be a potential biomarker for injury, rehabilitation, or disease.
description: 29 pages, 11 figures
Quantum trajectories under frequent measurements in non-Markovian environment
Creators: name: Xu, Luting
name: Li, Xin-Qi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work we generalize the quantum trajectory (QT) theory from Markovian to non-Markovian environments. We model the non-Markovian environment by using a Lorentzian spectral density function with bandwidth ($Λ$), and find perfect "scaling" property with the measurement frequency ($τ^{-1}$) in terms of the scaling variable $x=Λτ$. Our result bridges the gap between the existing QT theory and the Zeno effect, by rendering them as two extremes corresponding to $x\to\infty$ and $x\to 0$, respectively. This $x$-dependent criterion improves the idea of using $τ$ alone, and quantitatively identifies the validity condition of the conventional QT theory.
description: 6 pages, 2 figures; version published in PRA
Benzene Exposure Near the U.S. Permissible Limit Is Associated with Sperm Aneuploidy
Creators: name: Schmid, Thomas E.
name: Kurtovich, Elaine
name: Eskenazi, Brenda
name: Wyrobek, Andrew J.
name: Zhang, Luoping
name: Xing, Caihong
name: Li, Guilan
name: Waidyanatha, Suramya
name: Weldon, Rosana H.
name: Marchetti, Francesco
name: Young, Suzanne
name: Rappaport, Stephen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundBenzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Occupational Safety and Health Administration.ObjectiveWe investigated whether occupational exposures to benzene near 1 ppm induce aneuploidy in sperm.MethodsWe used multicolor fluorescence in situ hybridization to measure the incidence of sperm with numerical abnormalities of chromosomes X, Y, and 21 among 33 benzene-exposed men and 33 unexposed men from Chinese factories. Individual exposures were assessed using personal air monitoring and urinary concentrations of benzene and trans,trans-muconic acid (E,E-MA). Air benzene concentrations were not detectable in unexposed men; in exposed men, concentrations ranged from below the detection limit to 24 ppm (median, 2.9 ppm), with 27% of exposed men (n = 9) having concentrations of ≤ 1 ppm. Exposed men were categorized into low and high groups based on urinary E,E-MA (median concentrations of 1.9 and 14.4 mg/L, respectively; median air benzene of 1 and 7.7 ppm, respectively), and aneuploidy frequencies were compared with those of unexposed men.ResultsSperm aneuploidy increased across low- and high-exposed groups for disomy X [incidence rate ratio (IRR) = 2.0; 95% confidence interval (CI), 1.1–3.4; and IRR = 2.8; 95% CI, 1.5–4.9, respectively], and for overall hyperhaploidy for the three chromosomes investigated (IRR = 1.6; 95% CI, 1.0–2.4; and IRR = 2.3; 95% CI, 1.5–3.6, respectively). We also found elevated disomy X and hyperhaploidy in the nine men exposed to ≤ 1 ppm benzene compared with unexposed men (IRR = 1.8; 95% CI, 1.1–3.0; and IRR = 2.0; 95% CI, 1.1–3.9, respectively).ConclusionsBenzene appeared to increase the frequencies of aneuploid sperm for chromosomes associated with chromosomal abnormality syndromes in human offspring, even in men whose air benzene exposure was at or below the U.S. permissible exposure limit.
Foundations of Model-Based Deep Learning: Applications, Interpretability and Performance Guarantees
Creators: name: Khobahi, Shahin
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: In this thesis we lay the foundations of model-based deep learning with applications in various signal processing fields such as communication systems, compressive sensing, phase retrieval, radar signal processing, and image processing. Furthermore, we provide theoretical analysis of the proposed ideas, and specifically, presenting performance guarantees for the obtained model-based deep architectures.
Cancer Risks near Nuclear Facilities: The Importance of Research Design and Explicit Study Hypotheses
Creators: name: Wing, Steve
name: Richardson, David B.
name: Hoffmann, Wolfgang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundIn April 2010, the U.S. Nuclear Regulatory Commission asked the National Academy of Sciences to update a 1990 study of cancer risks near nuclear facilities. Prior research on this topic has suffered from problems in hypothesis formulation and research design.ObjectivesWe review epidemiologic principles used in studies of generic exposure–response associations and in studies of specific sources of exposure. We then describe logical problems with assumptions, formation of testable hypotheses, and interpretation of evidence in previous research on cancer risks near nuclear facilities.DiscussionAdvancement of knowledge about cancer risks near nuclear facilities depends on testing specific hypotheses grounded in physical and biological mechanisms of exposure and susceptibility while considering sample size and ability to adequately quantify exposure, ascertain cancer cases, and evaluate plausible confounders.ConclusionsNext steps in advancing knowledge about cancer risks near nuclear facilities require studies of childhood cancer incidence, focus on in utero and early childhood exposures, use of specific geographic information, and consideration of pathways for transport and uptake of radionuclides. Studies of cancer mortality among adults, cancers with long latencies, large geographic zones, and populations that reside at large distances from nuclear facilities are better suited for public relations than for scientific purposes.
Three red giants with substellar-mass companions
Creators: name: Niedzielski, A.
name: Wolszczan, A.
name: Nowak, G.
name: Adamów, M.
name: Kowalik, K.
name: Maciejewski, G.
name: Deka-Szymankiewicz, B.
name: Adamczyk, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present three giant stars from the ongoing Penn State-Toruń Planet Search with the Hobby-Eberly Telescope, which exhibit radial velocity variations that point to a presence of planetary --mass companions around them. BD+49 828 is a $M=1.52 \pm 0.22$ $M_{\odot}$ K0 giant with a $m sini$=$1.6^{+0.4}_{-0.2}$ $M_{J}$ minimum mass companion in $a=4.2^{+0.32}_{-0.2}$ AU ($2590^{+300}_{-180}$d), $e=0.35^{+0.24}_{-0.10}$ orbit. HD 95127, a log$L$/$L_{\odot}$=$2.28 \pm 0.38$, $R = 20\pm 9$ $R_{\odot}$, $M=1.20 \pm 0.22$ $M_{\odot}$ K0 giant has a $m sini$=$5.01^{+0.61}_{-0.44}$ $M_{J}$ minimum mass companion in $a=1.28^{+0.01}_{-0.01}$ AU ($482^{+5}_{-5}$d), $e=0.11^{+0.15}_{-0.06}$ orbit. Finally, HD 216536, is a $M=1.36 \pm 0.38$ $M_{\odot}$ K0 giant with a $m sin i=1.47^{+0.20}_{-0.12}$ $M_{J}$ minimum mass companion in $a=0.609^{+0.002}_{-0.002}$ AU ($148.6^{+0.7}_{-0.7}$d), $e=0.38^{+0.12}_{-0.10}$ orbit. Both, HD 95127 b and HD 216536 b in their compact orbits, are very close to the engulfment zone and hence prone to ingestion in the near future. BD+49 828 b is among the longest period planets detected with the radial velocity technique until now and it will remain unaffected by stellar evolution up to a very late stage of its host. We discuss general properties of planetary systems around evolved stars and planet survivability using existing data on exoplanets in more detail.
description: 47 pages, 11 figures. Accepted by ApJ
Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene
Creators: name: Latendresse, John R.
name: Koturbash, Igor
name: Sorrentino, Jessica
name: Swenberg, James A.
name: Rusyn, Ivan
name: Tryndyak, Volodymyr
name: Bodnar, Wanda
name: Sexton, Kenneth
name: Scherhag, Anne
name: Beland, Frederick A.
name: Pogribny, Igor P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Background1,3-Butadiene (BD) is a high-volume industrial chemical and a known human carcinogen. The main mode of BD carcinogenicity is thought to involve formation of genotoxic epoxides.ObjectivesIn this study we tested the hypothesis that BD may be epigenotoxic (i.e., cause changes in DNA and histone methylation) and explored the possible molecular mechanisms for the epigenetic changes.Methods and ResultsWe administered BD (6.25 and 625 ppm) to C57BL/6J male mice by inhalation for 2 weeks (6 hr/day, 5 days a week) and then examined liver tissue from these mice for signs of toxicity using histopathology and gene expression analyses. We observed no changes in mice exposed to 6.25 ppm BD, but glycogen depletion and dysregulation of hepatotoxicity biomarker genes were observed in mice exposed to 625 ppm BD. We detected N-7-(2,3,4-trihydroxybut-1-yl)guanine (THB-Gua) adducts in liver DNA of exposed mice in a dose-responsive manner, and also observed extensive alterations in the cellular epigenome in the liver, including demethylation of global DNA and repetitive elements and a decrease in histone H3 and H4 lysine methylation. In addition, we observed down-regulation of DNA methyltransferase 1 (Dnmt1) and suppressor of variegation 3–9 homolog 1, a histone lysine methyltransferase (Suv39h1), and up-regulation of the histone demethylase Jumonji domain 2 (Jmjd2a), proteins responsible for the accurate maintenance of the epigenetic marks. Although the epigenetic effects were most pronounced in the 625-ppm exposure group, some effects were evident in mice exposed to 6.25 ppm BD.ConclusionsThis study demonstrates that exposure to BD leads to epigenetic alterations in the liver, which may be important contributors to the mode of BD carcinogenicity.
Epigenetic Changes Induced by Air Toxics: Formaldehyde Exposure Alters miRNA Expression Profiles in Human Lung Cells
Creators: name: Fry, Rebecca C.
name: Sexton, Kenneth G.
name: Jaspers, Ilona
name: Smeester, Lisa
name: Rager, Julia E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundExposure to formaldehyde, a known air toxic, is associated with cancer and lung disease. Despite the adverse health effects of formaldehyde, the mechanisms underlying formaldehyde-induced disease remain largely unknown. Research has uncovered microRNAs (miRNAs) as key posttranscriptional regulators of gene expression that may influence cellular disease state. Although studies have compared different miRNA expression patterns between diseased and healthy tissue, this is the first study to examine perturbations in global miRNA levels resulting from formaldehyde exposure.ObjectivesWe investigated whether cellular miRNA expression profiles are modified by formaldehyde exposure to test the hypothesis that formaldehyde exposure disrupts miRNA expression levels within lung cells, representing a novel epigenetic mechanism through which formaldehyde may induce disease.MethodsHuman lung epithelial cells were grown at air–liquid interface and exposed to gaseous formaldehyde at 1 ppm for 4 hr. Small RNAs and protein were collected and analyzed for miRNA expression using microarray analysis and for interleukin (IL-8) protein levels by enzyme-linked immunosorbent assay (ELISA).ResultsGaseous formaldehyde exposure altered the miRNA expression profiles in human lung cells. Specifically, 89 miRNAs were significantly down-regulated in formaldehyde-exposed samples versus controls. Functional and molecular network analysis of the predicted miRNA transcript targets revealed that formaldehyde exposure potentially alters signaling pathways associated with cancer, inflammatory response, and endocrine system regulation. IL-8 release increased in cells exposed to formaldehyde, and results were confirmed by real-time polymerase chain reaction.ConclusionsFormaldehyde alters miRNA patterns that regulate gene expression, potentially leading to the initiation of a variety of diseases.
Purification of SLC12A9 from Expi293FTM Cells
Creators: name: David B. Sauer
name: Huanyu Li
name: Sagar Raturi
name: Andreea Scacioc
name: Tina Bohstedt
name: Abilasha Balakrishnan
Publisher: name: Zenodo
Year: 2022
Subjects: Protocol

description: This protocol is used to purify the SLC transporter expressed in Expi293FTM Cells using detergent solubilization followed by a series of different chromatographic methods. Depending on the nature of the expression construct and experimental requirements, the GFP tag can be removed using a proteolytic reaction.
Bharatohydracarus phreaticus Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Hungarohydracaridae
Bharatohydracarus
Bharatohydracarus phreaticus

description: Bharatohydracarus phreaticus Cook, 1967
Records from the study area: Maharashtra, Karnataka—Cook (1967); Prasad (1974); Pešić & Ranga Reddy (2009).
Habitat: Hyporheic interstitial.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 48, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Estimating Error in Using Residential Outdoor PM2.5 Concentrations as Proxies for Personal Exposures: A Meta-analysis
Creators: name: Avery, Christy L.
name: Williams, Ronald
name: Mills, Katherine T.
name: Whitsel, Eric A.
name: Poole, Charles
name: McGraw, Kathleen A.
name: Smith, Richard L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundStudies examining the health effects of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) commonly use ambient PM2.5 concentrations measured at distal monitoring sites as proxies for personal exposure and assume spatial homogeneity of ambient PM2.5. An alternative proxy—the residential outdoor PM2.5 concentration measured adjacent to participant homes—has few advantages under this assumption.ObjectivesWe systematically reviewed the correlation between residential outdoor PM2.5 and personal PM2.5 (r̄j) as a means of comparing the magnitude and sources of measurement error associated with their use as exposure surrogates.MethodsWe searched seven electronic reference databases for studies of the within-participant residential outdoor-personal PM2.5 correlation.ResultsThe search identified 567 candidate studies, nine of which were abstracted in duplicate, that were published between 1996 and 2008. They represented 329 nonsmoking participants 6–93 years of age in eight U.S. cities, among whom r̄j was estimated (median, 0.53; range, 0.25–0.79) based on a median of seven residential outdoor-personal PM2.5 pairs per participant. We found modest evidence of publication bias (symmetric funnel plot; pBegg = 0.4; pEgger = 0.2); however, we identified evidence of heterogeneity (Cochran’s Q-test p = 0.05). Of the 20 characteristics examined, earlier study midpoints, eastern longitudes, older mean age, higher outdoor temperatures, and lower personal-residential outdoor PM2.5 differences were associated with increased within-participant residential outdoor-personal PM2.5 correlations.ConclusionsThese findings were similar to those from a contemporaneous meta-analysis that examined ambient-personal PM2.5 correlations (r̄j = median, 0.54; range, 0.09–0.83). Collectively, the meta-analyses suggest that residential outdoor-personal and ambient-personal PM2.5 correlations merit greater consideration when evaluating the potential for bias in studies of PM2.5-mediated health effects.
Vários, Le développement des peuples. Lettre encyclique «Populorum Progressio». Mame. Vivre le Concile. Vol. de 197 ps. 115x215. Paris 1967
Creators: name: Marques, José Silva
Publisher: name: Theologica
Year: 1968

description: Theologica, v. 3 n. 3 (1968)
Meeting Report: Pharmaceuticals in Water—An Interdisciplinary Approach to a Public Health Challenge
Creators: name: Rodriguez-Mozaz, Sara
name: Weinberg, Howard S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundThe presence of pharmaceuticals in aquatic environments and in drinking water has prompted significant public interest regarding potential adverse ecological effects and risks to human health.ObjectivesThe Environmental Health Summit held in North Carolina, 10–11 November 2008, explored the issues associated with the presence and relative risk of trace levels of pharmaceuticals in water. More than 150 participants from government organizations and institutions, academia, industry, water utilities, and public interest groups participated in discussions aimed at evaluating the current knowledge on this issue and at identifying research gaps and innovative solution-oriented recommendations.DiscussionWe present different aspects related to the subject that were discussed at the summit, including the source, fate, and transport of pharmaceuticals, their exposure effects and potential risks to human and ecosystems, and the best management practices to address these issues. Recommendations placed emphasis on research needs as well as education, communication, prevention, and intervention programs, and other public health solutions and actions.ConclusionsDespite rising concerns about the presence of trace amounts of pharmaceuticals in drinking water, little evidence is currently available that associates these chemicals with adverse human health risks. In order to prioritize which pharmaceutical chemicals could potentially pose the highest risk to consumers and the environment, the summit participants concluded that more studies are needed to generate meaningful and accurate data.
title: Multichannel single center method
Creators: name: Novikovskiy, Nikolay M.
name: Artemyev, Anton N.
name: Rezvan, Dmitrii V.
name: Lagutin, Boris M.
name: Demekhin, Philipp V.
Publisher: name: Universität Kassel
Year: 2022
Subjects: subject: computational and mathematical techniques in atomic and molecular physics
subject: photon interactions with molecules
subject: photoionization and photodetachment
subject: 530
subject: Mathematische Methode
subject: Computerunterstütztes Verfahren
subject: Molekülphysik
subject: Photon
subject: Wechselwirkung
subject: Fotoionisation

description: Gefördert im Rahmen eines Open-Access-Transformationsvertrags mit dem Verlag
Phosphorylation of p65 Is Required for Zinc Oxide Nanoparticle–Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells
Creators: name: Peden, David B.
name: Wu, Weidong
name: Samet, James M.
name: Bromberg, Philip A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundExposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8).ObjectiveWe investigated the effect of ZnO nanoparticles on IL-8 expression and the underlying mechanisms in human bronchial epithelial cells.MethodsWe determined IL-8 mRNA and protein expression in primary human bronchial epithelial cells and the BEAS-2B human bronchial epithelial cell line using reverse-transcriptase polymerase chain reaction and the enzyme-linked immunosorbent assay, respectively. Transcriptional activity of IL-8 promoter and nuclear factor kappa B (NFκB) in ZnO-treated BEAS-2B cells was measured using transient gene transfection of the luciferase reporter construct with or without p65 constructs. Phosphorylation and degradation of IκBα, an inhibitor of NF-κB, and phosphorylation of p65 were detected using immunoblotting. Binding of p65 to the IL-8 promoter was examined using the chromatin immunoprecipitation assay.ResultsZnO exposure (2–8 μg/mL) increased IL-8 mRNA and protein expression. Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity. Further study demonstrated that the κB-binding site in the IL-8 promoter was required for ZnO-induced IL-8 transcriptional activation. ZnO stimulation modestly elevated IκBα phosphorylation and degradation. Moreover, ZnO exposure also increased the binding of p65 to the IL-8 promoter and p65 phosphorylation at serines 276 and 536. Overexpression of p65 constructs mutated at serines 276 or 536 significantly reduced ZnO-induced increase in IL-8 promoter reporter activity.Conclusionp65 phosphorylation and IκBα phosphorylation and degradation are the primary mechanisms involved in ZnO nanoparticle-induced IL-8 expression in human bronchial epithelial cells.
Matrix product operators for symmetry-protected topological phases: Gauging and edge theories
Creators: name: Williamson, Dominic J.
name: Bultinck, Nick
name: Mariën, Michael
name: Sahinoglu, Mehmet B.
name: Haegeman, Jutho
name: Verstraete, Frank
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Projected entangled pair states (PEPS) provide a natural ansatz for the ground states of gapped, local Hamiltonians in which global characteristics of a quantum state are encoded in properties of local tensors. We develop a framework to describe on-site symmetries, as occurring in systems exhibiting symmetry-protected topological (SPT) quantum order, in terms of virtual symmetries of the local tensors expressed as a set of matrix product operators (MPOs) labeled by distinct group elements. These MPOs describe the possibly anomalous symmetry of the edge theory, whose local degrees of freedom are concretely identified in a PEPS. A classification of SPT phases is obtained by studying the obstructions to continuously deforming one set of MPOs into another, recovering the results derived for fixed-point models [X. Chen et al., Phys. Rev. B 87, 155114 (2013)]. Our formalism accommodates perturbations away from fixed point models, opening the possibility of studying phase transitions between different SPT phases. We also demonstrate that applying the recently developed quantum state gauging procedure to a SPT PEPS yields a PEPS with topological order determined by the initial symmetry MPOs. The MPO framework thus unifies the different approaches to classifying SPT phases, via fixed-points models, boundary anomalies, or gauging the symmetry, into the single problem of classifying inequivalent sets of matrix product operator symmetries that are defined purely in terms of a PEPS.
description: 16 + 19 pages, 13 figures; v2 substantial changes to all sections, new appendices added; v3 published version
Baraúna, G. (dir. por), A Igreja no Mundo de Hoje. Estudos e Comentários em torno da Constituição «Gaudium et Spes» do Vaticano II, com um estudo sobre a «Populorum Progressio». Vozes. Vol. de 727 ps. 155x225. Petrópolis 1967
Creators: name: Marques, José Silva
Publisher: name: Theologica
Year: 1968

description: Theologica, v. 3 n. 3 (1968)
Hierarchy in Gene Expression is Predictive for Adult Acute Myeloid Leukemia
Creators: name: Tripathi, Shubham
name: Deem, Michael W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Tissues and Organs (q-bio.TO)
subject: FOS: Biological sciences

description: Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients. With a retrospective cohort analysis based on the gene expression profiles of 116 acute myeloid leukemia patients, we find that the likelihood of future cancer relapse and the level of clinical risk are directly correlated with the level of organization in the cancer related gene network. We also explore the variation of the level of organization in the gene network with cancer progression. We find that this variation is non-monotonic, which implies the fitness landscape in the evolution of AML cancer cells is nontrivial. We further find that the hierarchy in gene expression at the time of diagnosis may be a useful biomarker in AML prognosis.
description: 18 pages, 5 figures, to appear in Physical Biology
EXISTENCE AND ABSURDITY IN ERNEST HEMINGWAY'S "THE OLD MAN AND THE SEA"
Creators: name: Rizayeva, Shaxnozabonu
Publisher: name: Zenodo
Year: 2025

description: Ernest Hemingway's novella "The Old Man and the Sea" explores profound themes of existence and absurdity through the struggles of Santiago, an aging fisherman. This article examines how Santiago's relentless battle with the marlin serves as a metaphor for the human condition, emphasizing resilience in the face of life's inherent absurdities. By delving into Santiago's isolation, the futility of his efforts, and his embodiment of the tragic hero, the narrative highlights the complexities of finding meaning in an indifferent world. Ultimately, Hemingway’s work invites readers to confront their own struggles and find purpose in the act of striving.
title: Towards strategic evaluation of regional spatial policies : a case study of North West England
Creators: name: Rae, Alasdair.
Publisher: name: University of Liverpool Repository
Year: 2023

description: Over the last forty years, but particularly in the past two decades, the regions of England have been subject to a wide variety of policy interventions, targeted on specific places. These locations are typically deprived inner-cities or other economically lagging areas, of which there a disproportionately large number in England's North West. Given the current vogue for evidence-based policy and the mantra of 'value for money' that now suffuses central government, there is a strong imperative to determine the extent to which such policies actually work. Whereas most spatial policy evaluations are predisposed to answering the question of what has happened, and when, this research seeks to answer the fundamentally spatial question of where impacts have occurred, regardless of the intended target area. At present, the methods available to determine the extent to which particular policy instruments have spatial effects are limited. This represents something of a strategic oversight for national and regional government, since any spatial effects generated by targeted policy could, in theory, have negative impacts for a wider region, thereby nullifying any local success. Such a result could work against the government's stated desire to reduce the persistent gap in growth rates between regions, it is argued. This 'gap in the market' of spatial policy is unfortunate, but it is also opportune since it provides the substantive justification for this thesis and for further work in the field. The aim of the research is to develop methods to test for the spatial effects of area based policy in England's North West - though such methods could, of course, be applied in other regions. This is achieved in several stages. First, a conceptual framework for understanding spatial effects is forwarded, followed by an examination of the rationale and objectives for area based intervention. In this part, particular attention is paid to the Single Regeneration Budget. Second, the methodological framework is proposed so that the North West can be used as a test case in order to determine the nature and extent of spatial processes resulting from targeted policy. Third, the methods previously identified are applied and tested with reference to the urban core of the North West. A combination of strategic economic indicators, regional analysis techniques and dynamic data analysis is used here. Finally, conclusions are drawn as to the validity of the methods and the extent of any spatial effects that result from area based policy intervention. By going beyond the boundaries of traditional area based policy evaluation methods, this research shows that spatial effects are identifiable in the North West and that they are often unfavourable for the very locations targeted by policy in the first place.
On the genetic optimization of APSK constellations for satellite broadcasting
Creators: name: Meloni, Alessio
name: Murroni, Maurizio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Both satellite transmissions and DVB applications over satellite present peculiar characteristics that could be taken into consideration in order to further exploit the optimality of the transmission. In this paper, starting from the state-of-the-art, the optimization of the APSK constellation through asymmetric symbols arrangement is investigated for its use in satellite communications. In particular, the optimization problem is tackled by means of Genetic Algorithms that have already been demonstrated to work nicely with complex non-linear optimization problems like the one presented hereinafter. This work aims at studying the various parameters involved in the optimization routine in order to establish those that best fit this case, thus further enhancing the constellation.
description: IEEE International Symposium on Broadband Multimedia Systems and Broadcasting (BMSB), 2014; IEEE proceedings, 2014
ISS Parafoil Experimental Rocket
Creators: name:  I. AENISHANSLIN
name:   J. PAIN
name:   P. LOISEAU
name:   R. THUILLER
name:   A. GOHAR
name:   B. LEMAIRE
name:   R. VALETTE
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: SPACE
ADVANCED TECHNOLOGIES
REUSABILITY

description: For the sake of sustainability, space industry provides great efforts in the research of rocket recovery and reusability systems. The PERSEUS project (Programme Etudiant de Recherche Spatiale Europeen Universitaire et Scientifique) initiated by CNES adapted its roadmap towards this kind of technology three years ago. The general aim of PERSEUS is to help students discover space programs through innovative projects so that they get interested in embracing a professional carrier in space industy. As part of the PERSEUS project, our association Ipsa Space Systems decided to begin the very first study on GNC Parafoil to recover a rocket stage as soon as PERSEUS announced its new roadmap. It was the moment the IPER (ISS Parafoil Experimental Rocket) project was born, hoping to demonstrate a first rocket recovery by self-guided (GNC) parafoil system. IPER is a 3 meters long experimental rocket with a diameter of 160 mm. It has a dry mass of 15 kg at launch and an apogee expected to reach around 1190 meters, which gives enough time to control the parafoil and respect the rules imposed by the launch site specifications. The rocket is composed of three different parts coupled with three separation systems. Each part is equipped with a chute in order to recover the entire rocket in all possible flight scenarios. The main chute is a five meters wingspan parafoil controlled with actuators. The second parachute recovers the fairing part, and the last one is an emergency chute that is to be deployed if anything goes wrong during the flight. In a nominal flight scenario, the parafoil will bring back the rocket body and all its subsystems to specified coordinates. IPERs flight plan is to deploy the first (drag) chute at apogee in order to descend at a sink rate of 17 m/s. When reaching an altitude of 500 meters, the wingspan parafoil is to be deployed after the separation of the nose cone that will descend alone under the drag chute. The vertical speed of the rocketss body will then decrease to 2 m/s. Two actuators connected to the parafoils brakes will control the descent trajectory until landing. If for any reason one of the previous chutes does not deploy as intended, the safety separation system will ensure a safe return to the ground. The IPER rocket demonstrator already flew in 2021 after two years of development. The goal of this test flight was to experiment all the different subsystems without the GNC since it was not complete at this time. Several protoyped tests have also been realized in order to experimentally establish a mathematical model for the parafoils behaviour during the flight. For next and last launch in July 2022, the objective is to finally fly and recover the rocket with GNC parafoil.
Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation
Creators: name: Fostel, Jennifer
name: Marzec, Jacqui
name: Howden, Reuben
name: Bauer, Alison K.
name: Cho, Hye-Youn
name: Kleeberger, Steven R.
name: Backus, Gillian S.
name: Peden, David B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundThe mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators.ObjectivesWe investigated the molecular mechanisms underlying interleuken-10 (IL-10)–mediated attenuation of O3-induced pulmonary inflammation in mice.MethodsIl10-deficient (Il10−/−) and wild-type (Il10+/+) mice were exposed to 0.3 ppm O3 or filtered air for 24, 48, or 72 hr. Immediately after exposure, differential cell counts and total protein (a marker of lung permeability) were assessed from bronchoalveolar lavage fluid (BALF). mRNA and protein levels of cellular mediators were determined from lung homogenates. We also used global mRNA expression analyses of lung tissue with Ingenuity Pathway Analysis to identify patterns of gene expression through which IL-10 modifies O3-induced inflammation.ResultsMean numbers of BALF polymorphonuclear leukocytes (PMNs) were significantly greater in Il10−/− mice than in Il10+/+ mice after exposure to O3 at all time points tested. O3-enhanced nuclear NF-κB translocation was elevated in the lungs of Il10−/− compared with Il10+/+ mice. Gene expression analyses revealed several IL-10–dependent and O3-dependent mediators, including macrophage inflammatory protein 2, cathepsin E, and serum amyloid A3.ConclusionsResults indicate that IL-10 protects against O3-induced pulmonary neutrophilic inflammation and cell proliferation. Moreover, gene expression analyses identified three response pathways and several genetic targets through which IL-10 may modulate the innate and adaptive immune response. These novel mechanisms of protection against the pathogenesis of O3-induced pulmonary inflammation may also provide potential therapeutic targets to protect susceptible individuals.
Using motopumps to increase rocket engine performances
Creators: name:  E. BOUISSON
name:   J. SENON
name:   M. SAUZEAT
name:   P. PEMPIE
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: SPACE
ADVANCED TECHNOLOGIES
REUSABILITY

description: The performance of a rocket engine is largely related to the pressure in the combustion chamber. This performance is measured in specific impulse (Isp), which is simply the quotient of the thrust produced over the propellant flow rate and the gravitational constant. This means that a high Isp translates into high thrust using less propellant. Designing a rocket engine with a high chamber pressure allows this Isp to be increased, and therefore the efficiency of the engine. However, to achieve high chamber pressure, the engine\'s propellant supply system must be able to bring the propellant to this pressure. A multitude of processes are used, from the simplest, such as pressure fed, which consists of pressurising the tanks, to the various turbopump cycles using high-speed pumps coupled to a turbine. The main disadvantage of pressure fed is that it increases the thickness - and therefore the mass - of the tanks, which limits the usable pressure in the chamber. On the other hand, turbopump cycles are much more complex to design and, although efficient, are more suitable for engines with a wide thrust range. We propose here the use of motopumps, i.e. pumps driven by electric motors. This solution allows, for medium thrust range engines, to reach higher chamber pressure while reducing the complexity of a turbomachine cycle. On the other hand, the limitations will be related to the mass of the batteries required to operate the electric motor. As an example, this technology can be found on small and medium-sized launchers such as Rocket Lab\'s Electron with its Rutherford rocket engines. This technology is now being implemented in the CNES PERSEUS student project to equip a future LOX - Ethanol engine with 10 kN thrust and 40 bars in the chamber. The student association IPL, in collaboration with ENSTA-Paris, is designing a LOX and Ethanol motopump respectively. The LOX version produced by IPL will deliver 2.45 kg/s of this cryogenic fluid at a discharge pressure of 52 bar. The development of this pump involves dealing with high speeds - 50,000 rpm - and operating temperatures of -180C. But the project also involves the use of power electronics with currents exceeding 240 A and 60 V. The short-term objective is to test during 2022 with water on the IPL test bench and then in LOX on the PERSEUS test bench at Arianegroup in Vernon. In conclusion, the use of motor pumps in the context of a student project such as PERSEUS is an ideal solution for achieving better performance without entering into the complexity of traditional turbomachinery. The development of this type of technology remains a challenge in terms of the constraints to which this device will be subjected.
Anciaux, P., Sacrement et Vie. Fondements et orientations du renouveau dans la pastoralle des sacrements. Ed. Casterman. Archevêché de Malines-Bruxelles. Centre de formation théologique et pastorale
Creators: name: Marques, José Silva
Publisher: name: Theologica
Year: 1968

description: Theologica, v. 3 n. 3 (1968)
Tobacco Smoke Exposure and Altered Nasal Responses to Live Attenuated Influenza Virus
Creators: name: Jaspers, Ilona
name: Herbst, Margaret
name: Zhou, Haibo
name: Monaco, Jane
name: Noah, Terry L.
name: Horvath, Katie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundEpidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear.ObjectiveWe developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters nasal inflammatory and antiviral responses to live attenuated influenza virus (LAIV).MethodsThis was an observational cohort study comparing nasal mucosal responses to LAIV among young adult active smokers (n = 17), nonsmokers exposed to secondhand smoke (SHS; n = 20), and unexposed controls (n = 23). Virus RNA and inflammatory factors were measured in nasal lavage fluids (NLF) serially after LAIV inoculation. For key end points, peak and total (area under curve) responses were compared among groups.ResultsCompared with controls, NLF interleukin-6 (IL-6) responses to LAIV (peak and total) were suppressed in smokers. Virus RNA in NLF cells was significantly increased in smokers, as were interferon-inducible protein 10:virus ratios. Responses in SHS-exposed subjects were generally intermediate between controls and smokers. We observed significant associations between urine cotinine and NLF IL-6 responses (negative correlation) or virus RNA in NLF cells (positive correlation) for all subjects combined.ConclusionsNasal inoculation with LAIV results in measurable inflammatory and antiviral responses in human volunteers, thus providing a model for investigating environmental effects on influenza infections in humans. Exposure to cigarette smoke was associated with suppression of specific nasal inflammatory and antiviral responses, as well as increased virus quantity, after nasal inoculation with LAIV. These data suggest mechanisms for increased susceptibility to influenza infection among persons exposed to tobacco smoke.
Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity
Creators: name: Tropsha, Alexander
name: Richard, Ann
name: Zhu, Hao
name: Tang, Hao
name: Rusyn, Ivan
name: Sedykh, Alexander
name: Zhang, Liying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundQuantitative high-throughput screening (qHTS) assays are increasingly being used to inform chemical hazard identification. Hundreds of chemicals have been tested in dozens of cell lines across extensive concentration ranges by the National Toxicology Program in collaboration with the National Institutes of Health Chemical Genomics Center.ObjectivesOur goal was to test a hypothesis that dose–response data points of the qHTS assays can serve as biological descriptors of assayed chemicals and, when combined with conventional chemical descriptors, improve the accuracy of quantitative structure–activity relationship (QSAR) models applied to prediction of in vivo toxicity end points.MethodsWe obtained cell viability qHTS concentration–response data for 1,408 substances assayed in 13 cell lines from PubChem; for a subset of these compounds, rodent acute toxicity half-maximal lethal dose (LD50) data were also available. We used the k nearest neighbor classification and random forest QSAR methods to model LD50 data using chemical descriptors either alone (conventional models) or combined with biological descriptors derived from the concentration–response qHTS data (hybrid models). Critical to our approach was the use of a novel noise-filtering algorithm to treat qHTS data.ResultsBoth the external classification accuracy and coverage (i.e., fraction of compounds in the external set that fall within the applicability domain) of the hybrid QSAR models were superior to conventional models.ConclusionsConcentration–response qHTS data may serve as informative biological descriptors of molecules that, when combined with conventional chemical descriptors, may considerably improve the accuracy and utility of computational approaches for predicting in vivo animal toxicity end points.
Anatomy of Coannihilation with a Scalar Top Partner
Creators: name: Ibarra, A.
name: Pierce, A.
name: Shah, N. R.
name: Vogl, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate a simplified model of dark matter where a Majorana fermion $χ$ coannihilates with a colored scalar top partner $\tilde{t}$. We explore the cosmological history, with particular emphasis on the most relevant low-energy parameters: the mass splitting between the dark matter and the coannihilator, and the Yukawa coupling $y_χ$ that connects these fields to the Standard Model top quarks. We also allow a free quartic coupling $λ_h$ between a pair of Higgs bosons and $\tilde{t}$ pairs. We pay special attention to the case where the values take on those expected where $\tilde{t}$ corresponds to the superpartner of the right-handed top, and $χ$ is a bino. Direct detection, indirect detection, and colliders are complementary probes of this simple model.
description: 36 pages, 8 figures