cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A community renewal program; Project N.J. r-&3 (cr), Woodbridge Township, Middlesex County, New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1962

description: The objectives of the Community Renewal Program for Woodbridge were outlined to include a broad range of study:(a) analysis of the region and its significance to the community;(b) analysis of the existing and proposed physical and economic structure of the Township;(c) evaluation of the present governmental organization;(d) evaluation of the legal devices for controlling and guiding the present and future physical development within the Township;(e) analysis of the financial capacity of the municipality;(f) preparation of standards and criteria for evaluating the present physical condition of the community;(g) investigation of the problems of physical structure and composition for both the Township as a whole and section by section;(h) identification of areas of the Township requiring physical reorganization and improvement, and classification of these areas by type of assistance warranted;(i) development of a conceptual form for the future image of the Township;(j) Preliminary analysis of specific study areas and the economic resources available to deal with problems indicated;(k) assignment of priorities for a community program of action and for specific project implementation, and(I) recommendation of the administrative and governmental organizatiOn changes necessary for program implementation and of the codes and ordinances essential to guiding new development within the Township.
Tetramorium andrei Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium andrei

description: Tetramorium andrei Forel
(Fig. 14)
Tetramorium {Xiphomyrmex) andrei Forel, 1891 b: 263. Syntype workers, Madagascar: Bezanozano nr Nosibe, ESE. of Antananarivo (Sikora) (MHN, Geneva) [examined].
Worker. TL 4.3 - 4.8, HL 1.04 - 1.08, HW 0.92 - 0.96, CI 87 - 90, SL 0.80 - 0.84, SI 86 - 89, PW 0.70 - 0.72, AL 1.30 - 1.34 (6 measured).
Mandibles striate; median clypeal carina acute. Frontal carinae long and strong, diverging towards the occipital corners behind the level of the eyes but merging into the sculpture before reaching the occipital margin. Antennal scrobes a groove capable of containing the scape. Metanotal groove absent, not impressed in profile. Propodeal spines long and acute, the metapleural lobes short and triangular. Petiole node in profile longer than high, flat-topped or feebly convex dorsally, in dorsal view as long as or longer than broad. Dorsum of head regularly longitudinally rugose; dorsal alitrunk similarly sculptured but with some reticulation towards the sides on the pronotum. Petiole and postpetiole with rugose sculpture which is predominantly longitudinal. Gaster unsculptured except for pits from which hairs arise; these are more conspicuous in some specimens than in others. Dorsal surfaces of head and body all with numerous long, fine, erect to suberect hairs. Leading edges of antennal scape with suberect short, curved hairs. Colour light red-brown.
Of the tortuosum-group species on Madagascar andrei is most closely related to robustior, originally described as an infraspecific variant of andrei, and rather more distantly to latreillei and kelleri. Differences from robustior are listed under that species. T. andrei is distinguished easily from latreillei as the latter lacks hairs on the first gastral tergite and does not have standing hairs on the antennal scapes. T. kelleri, on the other hand, has abundant long hairs, the longest on the scapes being much greater than the maximum scapai width. Also, the node shape of the petiole is radically different, compare Figs 13 and 14.
Material examined
Madagascar: no loc. (Staudinger); no loc. (ex coll. Mayr); Ampasimbe, prov. Tamatave (J. M. Betsch).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 143-144
Astyanax orstedii Eigenmann 1908
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Astyanax
Astyanax orstedii

description: Astyanax orstedii Eigenmann 1908 (Fig 7B). Costa Rican Tetra; Sardina, Sardina de Río, Sardinilla, Sabalete, Sábalo, Sardina Común, Plateada, Machaca, Coliroja, Picaculo, Golosa, Tetra, Mojarra
Vouchers: UCR1062-001 (28). Distribution: Central America; from southern Nicaragua to western Panama,Atlantic and Pacific drainages; (Nicaragua) To, Sa, SJ, RF, LN (Atlantic), Ne, ER, PN and Ni (Pacific); 0–710 masl; Pri, Pot. Occurrence and conservation status: Nat; LC (2020), population trend stable. Literature: Meek (1907: 108, as A. aeneus, in part—misidentification; brief description, including an identification key, and information on distribution and ecology), Fowler (1923: 26, as A. aeneus, in part—misidentification; brief description, including information on distribution), Astorqui (1975: 81, as A. fasciatus, in part—misidentification; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 101, as A. fasciatus, in part—misidentification; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 79, as A. aeneus, in part—misidentification; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Schmitter-Soto (2017: 1398; redescription, including illustrations and an identification key, and information on distribution, with a map, and ecology), Angulo et al. (2018: 1867; identification key and information on distribution) and Angulo (2021: 26; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 24, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Regulation of the DNA damage response by SOCS3
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Solid tumors that are resistant to conventional treatment modalities such as chemotherapy and radiation are often difficult to treat and are characterized by poor survival rates. Much effort has been made toward the identification of novel biological response modifiers and biomarkers that can be manipulated in cancer to sensitize tumors to ionizing radiation (IR). We have identified Suppressor of Cytokine Signaling (SOCS)-3 as a novel biomarker of radioresistant tumors that protects cancer cells from IR through the STAT3-p21 pathway. In this study, we will identify the mechanism(s) by which SOCS3 protects cells from radiation and we will target SOCS3 expression in tumors as a potential novel therapeutic approach. In Specific Aim 1, we will determine whether SOCS3 regulates radiationresistant DNA synthesis and chromosome instability using embryonic fibroblasts (MEFs) from SOCS3-knockout mice. In Specific Aim 2, we will analyze the role of SOCS3 in regulating p21-mediated G1 arrest. We will analyze loading of STAT3 and p53 transcriptional complexes and chromatin structure at the p21 promoter by chromatin immunoprecipitation following irradiation of SOCS3-deficient cells. We will also determine whether targeting STAT3-dependent genes can alter the phenotype of SOCS3-/- MEFs following irradiation. In Specific Aim 3, we will genetically target SOCS3 expression in radiation-resistant glioma and breast cancer cell lines using short hairpin RNAs (shRNA), and measure cell cycle arrest, p21 gene activation, apoptosis, necrosis, and clonogenic survival in response to radiation to determine whether manipulating SOCS3 in cancer can improve responses to radiotherapy.
Genetic polymorphisms of nicotinic acetylcholine receptors that increase the risk for cancer of the cervix and other smoking related carcinomas
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We have found that proliferation and motility of cervical cancer cells are stimulated by nicotine. These responses are mediated by nicotinic acetylcholine receptors (nAChRs), which are expressed in healthy and neoplastic cervical cells. Cholinergic signaling is apparently a major synergistic progression factor in the papillomavirus initiated cervical carcinogenesis. Our observations explain the epidemiological finding that tobacco smoking is the principal behavioral risk factor to develop cervical cancer, and they point to the possibility that even in non-smokers the natural ligand of cholinergic signaling, acetylcholine, induces pathogenic loops due to autocrine signaling. In this project we will study the risk to develop cervical cancer that is associated with inherited genetic changes (single nucleotide polymorphisms, SNPs) of nAChR subunits. We will study two SNPs in the alpha-3 and -5 nAChR subunit genes that epidemiology linked to an increased risk to develop lung cancer, and five known nAChR SNPs that have not yet been assessed in cancer research. We will compare the prevalence of these SNPs between cervical carcinomas, precursor lesions and controls, and include samples from two cancers with a smoking related etiology, lung and pancreas cancer, and breast cancer, which is not yet confirmed to be linked to smoking. Our longstanding papillomavirus research has morphed into this novel line of search for molecular progression factors. This project will target DNA from cervical cancer specimens of our own collection as well as DNA from the biospecimen repository of cancer patients from Orange County established by Dr. Hoda Anton-Culver. Approximately 760 DNA specimens will be PCR amplified and sequenced. The molecular results will be statistically evaluated by Dr. Anton-Culver. Our research will establish the foundation for large epidemiological studies to identify nAChR variants that establish a high risk to develop certain cancers. It will lay the foundation for studying the molecular mechanisms of the role of nAChR signaling in cancer, and for examining known antinAChR repressors as leads for drugs useful in the management of these cancers. We anticipate applying for larger NIH grants in collaboration with Dr. Anton-Culver and Dr. S. Grando, a UCI based specialist for the role of nAChR signaling in cancer of the aerodigestive tract.
Development of a device for T-wave feature extraction and rapid baseline nulling
Creators: name: Smith, David Winfield
Publisher: name: No Publisher Supplied
Year: 2013

description: The T-wave of the electrocardiogram electrically represents ventricular repolarization – the relaxation phase of the cardiac cycle.  Discrete states of abnormal T-wave morphology are known to be associated with both pathologic and non-pathologic causes.  The links between causative factors and morphologic effects, however, are described as sensitive, but not specific.  This thesis aimed to develop a device that could accurately quantify the T-wave’s characteristic morphologic features on a beat-to-beat basis, in real-time, to improve specificity.    T-wave feature data were extracted with minimal noise using a novel analog electronic device design that allowed corrections for baseline drift and motion artifacts.  T-wave morphologies were then approximated by geometric composite figures constructed from each T-wave’s constituent data, namely, its height and leading and trailing edge slopes.  It was hypothesized that the T-wave approximation figures would convey clinically relevant information to an observer, notwithstanding their composition from highly compressed data.    Simulated T-wave monitor designs were tested on 2,604 T-waves from thirty-two real and synthetic ECG data sources.  Results from the study concluded that over 88% of the geometric composite figures were reasonable approximations of T-wave morphology.  Noise on the T-wave signal was the primary cause for less-than-reasonable approximations.  Feature accuracies were found to have less than 3% error when tested against a smaller subset of 260 T-wave controls.  Clinical meaningfulness of the composite figures was demonstrated by observation of T-wave alternans and the effects of oxygen saturation levels on T-wave morphology.  Average baseline drift was held to within 0.010 mV across a wide variety of input conditions.  Complete transient response recovery from ±300 mV input pulses sometimes occurred in less than one heartbeat.    The present novel methodology employed in the successfully tested T-wave monitor design can be extended to other ECG components, and has the potential to improve the accuracy of arrhythmia detection and classification in future applications.
Additional file 1: of ExUTR: a novel pipeline for large-scale prediction of 3′-UTR sequences from NGS data
Creators: name: Zixia Huang
name: Teeling, Emma
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Plant Biology

description: The detailed methods for the analyses of the demonstrated RNA-Seq data. (DOCX 149 kb)
Exploring student engagement and transfer in technology mediated environments
Creators: name: Sinha, Suparna
Publisher: name: No Publisher Supplied
Year: 2013

description: Computer-supported environments designed on learning science principles aim to provide a rich learning experience for students. Students are given opportunities to collaborate, model their understanding, have access to real-time data and engage in hypotheses testing to solve authentic problems. That is to say that affordances of technologies make it possible for students to engage in mechanistic reasoning, a complex inquiry-oriented practice (Machamer, Craver & Darden, 2000; Russ et al., 2008). However, we have limited understanding of the quality of engagement fostered in these contexts. This calls for close observations of the activity systems that the students participate in. The situative perspective focuses on analyzing interactions of individuals (students) with other people, tools and materials within activity systems (Greeno, 2006). Importantly, as the central goal of education is to provide learning experiences that are useful beyond the specific conditions of initial learning, analysis of such interactions sheds light on key experiences that lead to transfer of mechanistic reasoning skills. This is made possible, as computer-supported contexts are activity systems that bring forth trends in students’ engagement. From a curriculum design perspective, observing student engagement can be a useful tool to identify features of interactions (with technological tools, peers, curriculum materials) that lead to successful learning. Therefore, the purpose of the present studies is to explore the extent to which technological affordances influence students’ engagement and subsequent transfer of reasoning skills. Specifically, the goal of this research is to address the following research questions: How do learners generalize understanding of mechanistic reasoning in computer-supported learning environments?, What kinds of engagement with technological tools are needed to facilitate high quality conceptual understanding of the problem?, and How does engagement with technological affordances influence transfer of mechanistic reasoning skills?
Carlana eigenmanni
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Carlana
Carlana eigenmanni

description: Carlana eigenmanni (Meek 1912). Eigenmann’s Tetra; Sardina, Sardinita, Tetra, Sardinita de Eigenmann
Vouchers: UCR 0546-010 (2), 0552-006 (1), 1003-005 (1), 1004-008 (1), 1052-010 (4) and 1054-012 (19); other collections: CAS 61369 (8), 61380 (3), 67273 (1) and IBUNAM 13688 (1). Distribution: Central America; from southern Nicaragua to northern Costa Rica, Atlantic drainages; (Nicaragua) To, Sa, SJ, RF and LN (Atlantic); 6–61 masl; Pri, Pot. Occurrence and conservation status: Nat; VU B1ab(iii) (2020), population trend unknown. Literature: Astorqui (1975: 76, as Rhoadsia eigenmanni —synonym; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 105; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 100; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology) and Angulo (2021: 26; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 24, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Crepidomanes trinerve (Baker) Dubuisson & Ebihara
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Crepidomanes
Crepidomanes trinerve

description: Crepidomanes trinerve (Baker) Dubuisson & Ebihara
Crepidomanes trinerve (Baker) Dubuisson & Ebihara in Dubuisson et al., Acta Botanica Gallica, Botany Letters 160: 187 (2013b). – Trichomanes trinerve Baker, Flora of Mauritius and the Seychelles: 465 (1877). – Type: Mauritius, s. loc., s.d., H. Barkly and A.M. Barkly s.n. (holo-: K000228373!).
Trichomanes ambongoense Bonap., Notes ptéridologiques 9: 13 (1920a). – Type: Madagascar, s. loc., s.d., H.Perrier de la Bâthie 7501 (lecto-: P00466414!; isolecto-: P00466408!, designated by Dubuisson et al. 2013b); s. loc., s.d., H.Perrier de la Bâthie 7769 (syn-: P00466412!, P00466413!); s. loc., s.d., H.Perrier de la Bâthie 7770 (syn-: P00466410!, P00466411!); s. loc., s.d., H.Perrier de la Bâthie 7771 (syn-: P00466409!, P00482601!).
Trichomanes angustilaciniatum Bonap., Notes ptéridologiques 16: 11 (1925). – Type: Madagascar, s. loc., s.d., H.Perrier de la Bâthie 13756 (holo-: P00482604!; iso-: P00482603!).
Short description
Lithophytic, less often epiphytic; long-creeping filiform rhizomes, rootless and densely covered by dense black trichomes, bearing widely separated pending fronds; fronds with slightly winged stipes, up to 3.5(–5) cm long, flabellate to obovate, palmatisect to digitate, less often pinnatifid, with always, when dry, folds parallel to veins; sori few, paratactic, campanulate with a well dilated mouth.
Global distribution
Comoros, Madagascar, Mauritius, La Réunion.
Distribution in Comoros
Mayotte.
Additional specimens examined
COMOROS: MAYOTTE, Massif de Benara et Bépilipili, chemin de crête reliant les deux massifs, 9 Nov. 2002, F.Rakotondrainibe et al. 6651 (P00310478); Mont Tchaourembo, 13 Nov. 2002, F.Rakotondrainibe et al. 6682 (P00311398). NB: these specimens were used for the molecular phylogeny in Dubuisson et al. (2013b).
Note
Crepidomanes trinerve is often confused with the distinct C. minutum, the first being even considered as a synonym of the latter by Roux (2009). Both taxa are nevertheless clearly distinct based on the stipe which is terete and wingless in C. minutum and slightly but always winged in C. trinerve in addition to some sorus features (Dubuisson et al. 2013b). Crepidomanes trinerve, initially considered as endemic to Mauritius, is thus also present in Comoros (and in Madagascar and La Réunion).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on pages 13-14, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Eretmobrycon scleroparius
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Eretmobrycon
Eretmobrycon scleroparius

description: Eretmobrycon scleroparius (Regan 1908) (Fig. 7C). Creek Tetra; Sardina, Sardinilla, Sardina Panza Roja, Sardina de Quebrada, Sabalete, Plateada, Machaca, Tetra
Vouchers: UCR 0457-014 (1), 0458-006 (201), 0459-004 (16), 0460-001 (68), 0462-002 (3), 1055-005 (1) and 1062-008 (5). Distribution: Central America; from southern Nicaragua to western Colombia, Atlantic and Pacific drainages; (Nicaragua) Co, UI, WK, Pr, GM, KP, Es, BF, IM, To, Sa, SJ, RF and LN (Atlantic); 12–600 masl; Pri, Pot. Occurrence and conservation status: Nat; LC (2020), population trend stable. Literature: Astorqui (1975: 84, as Bryconamericus rica Eigenmann 1908 —synonym; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 103, as Bryconamericus scleroparius —synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 97, as B. scleroparius —synonym; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Román-Valencia (2002: 184, as B. scleroparius — synonym; detailed description, including illustrations and an identification key, and information on distribution, with a map, and ecology), González-Alemán (2006: 43, as B. scleroparius —synonym; brief description, including an illustration, and information on distribution and ecology), Gros & Miguel-Frithz (2010: 231, as B. scleroparius — synonym; brief description, including illustrations, and information on distribution and ecology, plus indigenous science and ethnoichthyology) and Angulo (2021: 26; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 24, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Regulation of CD44 in breast cancer cells
Creators: name: Smith, Shannon M.
Publisher: name: No Publisher Supplied
Year: 2013

description: In the United States, breast cancer is the most common form of non-skin cancer and the second leading cause of cancer related deaths in women. The National Cancer Institute recognizes two clinical challenges in breast cancer research.  First, the prevention of breast cancer is seen as a challenge due to the complex nature of the developing breast.  Second, there is no effective treatment for the metastatic diseases due to the presence of cancer stem-like cells.         Cancer stem-like cells (CSC) have the ability to continuously proliferate and differentiate, sustaining the original tumor and generating new tumors.  CSCs represent a small population of a tumor and can be identified by cell surface protein markers that distinguish the cells from the surrounding population of cancer cells.  In breast cancer, CSCs can be identified by the up-regulation of CD44, a cell surface glycoprotein, and the down-regulation of CD24, a cell adhesion molecule.         CD44 is a cell surface glycoprotein involved in a number of cellular processes, including cell adhesion, migration and cell-cell interactions.  The protein is a receptor for hyaluronic acid and it can interact with other ligands such as osteopontin and collagens.  Ongoing research of CD44 focuses on downstream effects of CD44 and how variant forms of CD44 function in cancer cells.  Despite the intense research aimed at understanding CD44’s role in cancer and cancer stem-like cells, little is known about its regulation in normal or cancer cells.        As an important component of gene transcription machinery, cis-regulatory elements are located in non-coding genomic DNA on the same chromosome as the gene of interest and are responsible for the up- and down-regulation of genes.  Cis-elements are often highly conserved and tend to be in regions of open chromatin configuration making them accessible to trans-acting factor binding proteins.  In this thesis, I have identified a highly conserved region, CR1, with the ability to direct gene expression in a cell specific manner.  Further analysis revealed that the trans-acting factor NFκB has the ability to bind CR1 and is involved in regulating CD44 expression.  Inhibition of NFκB resulted in reduced CD44 expression and subsequently a reduction in proliferation and invasiveness of breast cancer cells.        These findings provide new insight into molecular mechanism underlying CD44 regulation in breast cancer cells and offers new clues to therapeutic targets that may help eliminate chemo- and radiation-resistant cancer cells and subsequent metastasis.
Didymoglossum Desv. (Desvaux 1827
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum

description: Genus Didymoglossum Desv. (Desvaux 1827)
The most diversified genus in the archipelago (7 spp.) is pantropical and clusters more than 30 species which are epiphytic or lithophytic, minute to medium-sized with long-creeping and rootless rhizomes bearing fronds that are usually entire to lobed and in some cases pinnatifid (rarely bi-pinnatifid to bipinnate). The laminae exhibit false veins parallel to true veins, at least for the Comorian species (Fig. 2B, 2D). The two described subgenera Didymoglossum and Microgonium (C.Presl) Ebihara & K.Iwats. are represented in the Comoros by three and four species, respectively.
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 14, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Political ideology as moral vigilance
Creators: name: Stevens, Sean T.
Publisher: name: No Publisher Supplied
Year: 2013

description: Social Psychological research generally concludes that political ideology is an outcome variable, dependent on our underlying psychological motivations.  In the following paper, I propose a model of political ideology as moral vigilance – a general preparedness to detect moral transgressions of the values one highly emphasizes.  This perspective integrates Moral Foundations Theory with Error Management Theory and is developed and tested in two studies.  Study 1 replicates and extends research indicating that the Moral Foundations predict a wide variety of social and political attitudes, over and above demographic and cognitive flexibility variables.  In particular, the Moral Foundations of Sanctity, Fairness, and Liberty appear to underlie many social and political attitudes within the United States.  In Study 2 two statements, one ambiguously prejudiced statement and one ambiguously unpatriotic statement, made by an unknown individual in a television interview were presented.  Two patterns of results emerged.  First, those who placed a high emphasis on Loyalty found both statements offensive and desired greater social distance from the speaker.  Second, those who placed a high emphasis on Fairness (Liberty) appeared to infer similarity with the person who made the ambiguously unpatriotic (prejudiced) comment and reported the speaker was educated, in effect granting the speaker psychological standing for their position.
Deterrence of brain tumors by hindering atf5 function
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The National Cancer Institute estimates that in 2008, there were 21,810 diagnoses of brain tumors in the United States leading to approximately 13,070 deaths per year. Brain cancer is thought to arise from neural stem/progenitors that have transformed into a neoplasm. It is believed that these cells lead to a recurrence of the tumor after surgical resection. Objectives: To test my ongoing hypotheses: (1) Normal neural stem/progenitor cells are specific targets for mutations, that result from amplification of growth factor pathways leading to constitutive endogenous ATF5 expression. Earlier work showed that ATF5 plays a role in governing the proliferation of the resulting neural neoplasm. (2) The loss-of-function of ATF5 in neural tumors leads to apoptotic death of the tumors, but spares the non-neoplastic neural cells. Methods- Brain tumors will be created from normal neural progenitors of the postnatal brain by stereotactic PDGFB-retrovirus injection into the postnatal transgenic mouse brain. The loss of ATF5 function will be triggered by the withdrawal of the antibiotic doxycycline in a tetracycline inducible manner within the neural progenitors. The growth or eradication of the tumor initiated by loss of ATF5 function will be determined by MRI and by immunostaining the brain slices, respectively. The data will be presented as the mean tumor-to-normal tissue ratio with the hypothesis that loss of ATF5 will have the lowest tumor-to-normal tissue ratio compared to tumors from brains without an induced transgene. In brains with loss of ATF5 function, the number of apoptotic cells within the tumors will be the measurement for eradication. It will be determined whether eradication was autonomous within neoplastic cells or nonautonomous.
Hyphessobrycon tortuguerae Bohlke 1958
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Hyphessobrycon
Hyphessobrycon tortuguerae

description: Hyphessobrycon tortuguerae Böhlke 1958. Tortuguero Tetra; Sardina, Sardinita, Tetra, Tetra de Tortuguero, Sardinita de Tortuguero
Vouchers: UCR 0539-007 (1), 0542-007 (1), 0547-005 (1), 1051-010 (2), 1053-005 (1) and 1054-014 (70); LSUMZ 17143 (205); other collections: ANSP 169233 (1), CAS 61541 (1), 61368 (4), 61379 (7), LACM 2470 (7), UMMZ 188248 (1), 199631 (1), 199643 (1) and 199654 (1). Distribution: Central America; from eastern Honduras to northern Costa Rica, Atlantic drainages; (Nicaragua) Es, To, Sa, SJ, RF and LN (Atlantic); 9–50 masl; Pri, Pot. Occurrence and conservation status: Nat; LC (2020), population trend stable. Literature: Astorqui (1975: 78; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 105; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 110; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), González-Alemán (2006: 45, as Hyphessobrycon panamensis Durbin 1908 —misidentification; brief description, including an illustration, and information on distribution and ecology) and Angulo (2021: 27; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 25, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Tetramorium isectum Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium isectum

description: Tetramorium isectum sp. n.
(Figs 17, 18)
Holotype worker. TL 4.1, HL 0.96, HW 0.92, CI 96, SL 0.72, SI 78, PW 0.68, AL 1.12.
Mandibles strongly longitudinally striate, anterior clypeal margin with a distinct median impression. Eyes small, maximum diameter 0.14, about 0.15 x HW. Frontal carinae long and strong, running back to the occipital corner in full-face view and surmounted throughout their length by a narrow raised rim or flange. Antennal scrobes shallow and feeble, the sides of the head above the eye regularly longitudinally rugulose. Occipital margin of head markedly concave in full-face view, the sides shallowly but evenly convex. Pronotal dorsum transversely concave, the mesonotum and propodeum more or less flat. Anterior pronotal angles rounded in dorsal view. Propodeal spines elongate and narrow, elevated and feebly upcurved along their length. Metapleural lobes elongate triangular and acute. Shape of petiole as in Fig. 18, in dorsal view longer than broad and broader behind than in front. Clypeus with three longitudinal carinae. Dorsum of head strongly and regularly longitudinally rugose, the spaces between them with very faint superficial punctulation and with about 8 strong rugae between the frontal carinae at eye-level. Cross-meshes or anastomoses absent except laterally on the occiput. Dorsal alitrunk with very strongly raised longitudinal rugae, the five central ones of which run from pronotum to propodeum (the middle three most strongly defined). Outside these on the pronotum some rugoreticulum is present around the anterior angles, but this is absent elsewhere on the dorsal alitrunk. Dorsal surfaces of petiole and postpetiole rugulose, gaster unsculptured. All dorsal surfaces of body with abundant fine pilosity. Colour bright orange-brown.
Holotype worker, Madagascar: Beforona, 500 m, Sept. 1974, forest humus and litter (A. Peyrieras) (MCZ, Cambridge).
T. isectum is closest related to andrei and robustior, but the combination of small eyes, bright orange-brown colour, concave pronotum and very sharply defined longitudinal sculpture easily isolates this species.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 145
Women at war
Creators: name: Strong, Jessica D.
Publisher: name: No Publisher Supplied
Year: 2013

description: This qualitative, exploratory study examines the combat experiences of female veterans of Iraq and Afghanistan, and explores differences and similarities between male and female veterans’ descriptions of their combat experiences. Semi-structured interviews with 12 female and 5 male veterans provided data on definitions of combat and combat veteran, descriptors of and types of combat experiences, and the thoughts, feelings, bodily response and actions of the veterans during their combat experiences, as well as their coping behaviors immediately following the combat experience. These themes were then analyzed separately by gender and compared.   Findings from the female veterans’ interviews included heterogeneous definitions of combat and combat veteran, as well as a wide variety of types of experiences they considered to be combat. Female veterans reported combat experiences in three themes – experiencing combat or post-battle events, witnessing combat or post-battle events, and feeling threatened. Male and female veterans primarily differed in two areas – definition of combat and combat veteran and types of experiences they considered to be combat. Male and female veterans described similar responses to combat in thoughts, feelings, physical response, behavior, and coping immediately post-combat. This study has implications for social work practice and theory as well as important implications for the changing policies governing women in combat roles in the military.
Measuring mechanical forces generated following Notch ligand-receptor interactions using optical tweezers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Notch signaling induced by ligand involves a series of proteolytic cleavage events that release the Notch intracellular domain (NICD) from the plasma membrane, allowing Notch to move to the nucleus where it directly induces a transcriptional response. We have also imaged the transfer of the Notch extracellular domain (NECD) to ligand cells following interactions with Notch cells, and directly linked this event to the transfer of NICD to the nucleus for activation of Notch signaling. Since NECD transendocytosis by ligand cells does not require activating proteolysis, we propose that mechanical forces produced during ligand endocytosis of bound Notch function to physically dissociate Notch, and that this is a prerequisite for activating proteolysis in NICD generation. Given this potential role for mechanotransduction in Notch signaling, we have undertaken a biophysical approach to study ligand-induced Notch signaling. Specifically, optical laser tweezers will be used to present NECD-coated beads to ligand cells to detect and measure forces produced by ligand cells. Important to our biophysical approach, movement of the NECD-coated bead within the laser trap can be precisely measured and used to calculate mechanical forces exerted on trapped beads by contacted ligand cells. Moreover, direct comparisons with ligand cells defective in endocytosis will implicate ligand endocytosis, and identify the specific pathway that contributes to the mechanical forces. In addition, we will explore the idea that endocytosis is required to produce a ligand with enhanced binding potential; a hypothesis complimentary to our model that predicts that strong ligand binding would be necessary to sustain ligand-Notch interactions during NECD transendocytosis by ligand cells. Together these studies will provide data to support our hypothesis that ligand endocytosis produces a force to dissociate the Notch receptor and allow activating proteolysis to occur.
Reliability-based serviceability limit states for concrete girder bridges
Creators: name: Su, Dan
Publisher: name: No Publisher Supplied
Year: 2013

description: Although ultimate limit state, such as flexural capacity, shear, or stability, governs the overall safety of the structure, the accumulated damage due to cracking, excessive deflections, and vibrations also would lead to limitation of structural performance, abbreviation of service life, as well as extensive maintenance cost.  Regarding the bridge structure, current AASHTO LRFD Bridge Design Specification (LRFD) was developed based on structural reliability approach and provided a uniform reliability at strength limit state.  However, only strength limit states were considered and calibrated during the development and calibration of LRFD. Unlike strength limit state, exceedance of serviceability limit state in bridge structures might not result in catastrophic consequences directly. However, Serviceability limit states related to stress, deformation, and cracks under regular service conditions are essential to the performance, human experience, and durability of structure. To ensure consistent and rational reliability level to be achieved for all limit states, rational serviceability limit states need to be developed and investigated for bridge structures.  In this study, various serviceability limit states were developed and investigated, including Service I limit state for crack control of reinforced concrete decks and Service III limit state for tension in prestressed concrete superstructures. The resistances of various serviceability limit states were derived and the statistical models were developed based on statistics of various random variables and using different methods including Monte Carlo simulation method. The live load model was developed based on national as well as local Weigh-in-Motion (WIM) data using various extrapolation techniques.  Based on current practice, consequence of failure, and experience from previous research, target reliability indices were proposed for each serviceability limit state. Moreover, the reliability analysis was performed for various serviceability limit states and new design criteria were proposed to achieve the target reliability levels consistently for various design scenarios. In addition, the deterioration of structural resistance was investigated and the reliability level of various serviceability limit states with and without consideration of deterioration was compared.
Tetramorium kelleri Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium kelleri

description: Tetramorium kelleri Forel
(Fig. 13)
Tetramorium {Xiphomyrmex) kelleri Forel, 1887: 385. Syntype workers, Madagascar: nr Tamatave, bois de l'lvondro (C. Keller) (MHN, Geneva; BMNH; MCZ, Cambridge; USNM, Washington) [examined].
Worker. TL 4.9 - 5.3, HL 1.06 - 1.16, HW 0.90 - 0.98, CI 83 - 86, SL 0.84 - 0.94, SI 93 - 97, PW 0.72 - 0.82, AL 1.34 - 1.42 (8 measured).
Mandibles striate, median clypeal carina distinct. Frontal carinae strong, extended back nearly to the occipital margin and only very feebly curved so that they are roughly parallel throughout their length. Antennal scrobe a well-marked groove capable of holding the scape. Pronotal corners rounded in dorsal view. Metanotal groove absent to very weakly marked with the alitrunk in profile. Propodeal spines long and acute, the metapleural lobes low and rounded. Petiole in profile with the anterior and dorsal surfaces confluent through a broad curve or an extremely obtuse angle, the dorsum ascending posteriorly so that the anterior face of the node is distinctly shorter than the posterior. In dorsal view the petiole node much longer than broad. Head and dorsal alitrunk reticulate-rugose, the dorsal surfaces of the pedicel also rugose but here the rugae are longitudinal and are more strongly developed on the petiole than on the postpetiole. Gaster unsculptured. All dorsal surfaces of head and body with dense, long, fine hairs which are erect or suberect, and some of which are very long. Antennal scapes and legs also with abundant long, erect hairs, the longest on the scapes being almost or quite twice as long as the maximum scape width. Colour orange-brown.
Probably the most distinctive species of its group in the Malagasy region, the combination of large size, light colour, extreme hairiness and characteristic node shape makes kelleri immediately recognizable. Its nearest relatives do not appear to be any of the Malagasy species but rather it is closest related to pilosum Emery and yerburyi Forel of the Oriental region.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 145
Characterization and regulation of organic anion transporters
Creators: name: Suh, Wonmo
Publisher: name: No Publisher Supplied
Year: 2013

description: Human organic anion transporter 3 (hOAT3) belongs to a family of organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs. Therefore, understanding the regulation of this transporter has profound clinical significance. In the current study, we investigated the short-term and long-term regulation of hOAT3 by protein kinase C (PKC). We showed that short-term activation of PKC by phobol 12-Myristate 13-Acetate (PMA) inhibited hOAT3 activity through accelerating its internalization from cell surface to intracellular recycling endosomes. The colocalization of hOAT3 with EEA1-positive recycling endosomes was demonstrated by immunolocalization with confocal microscopy. Furthermore, we showed that long-term activation of PKC resulted in the enhanced degradation of cell surface hOAT3. The pathways for hOAT3 degradation were further examined using proteasomal and lysosomal inhibitors. Our results showed that both proteasomal inhibitors and the lysosomal inhibitors significantly blocked hOAT3 degradation. These results demonstrate that PKC plays critical roles in the trafficking and the stability of hOAT3.  I established five stable transfected cell lines. Those are COS-& cells stably  expressing hOAT3-c-myc, hOAT4-c-myc and HEK293 cells stably expressing hOAT1-c-myc, hOAT3-c-myc, hOAT4-c-myc. The stable transfected cell lines ensure long term and reproducible specific gene expression because it is accomplished by integration of transfected certain DNA of interest into cell’s chromosome.  By using HEK293 cells stably expressing hOAT4-c-myc I established, I did anti-cancer drug library screening. The purpose of this experiment is the investigation of anti-cancer drug which has function to inhibit hOAT4.