cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Across-cohort QC analyses of GWAS summary statistics from complex traits
Creators: name: Trzaskowski, Maciej
name: Yang, Jian
name: Robinson, Matthew R
name: Lee, Sang Hong
name: Visscher, Peter M.
name: Chen, Guo-Bo
name: Loos, Ruth J F
name: Zhu, Zhi-Xiang
name: Wray, Naomi R
name: Locke, Adam E
name: Winkler, Thomas W
name: Frayling, Timothy M
name: Hirschhorn, Joel N
name: Day, Felix R
name: Croteau-Chonka, Damien C
name: Wood, Andrew R
name: Kutalik, Zoltán
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires large genome-wide association meta-analyses (GWAMAs) to maximize statistical power. A trend towards ever-larger GWAMA is likely to continue, yet dealing with summary statistics from hundreds of cohorts increases logistical and quality control problems, including unknown sample overlap, and these can lead to both false positive and false negative findings. In this study, we propose four metrics and visualization tools for GWAMA, using summary statistics from cohort-level GWASs. We propose methods to examine the concordance between demographic information, and summary statistics and methods to investigate sample overlap. (I) We use the population genetics Fst statistic to verify the genetic origin of each cohort and their geographic location, and demonstrate using GWAMA data from the GIANT Consortium that geographic locations of cohorts can be recovered and outlier cohorts can be detected. (II) We conduct principal component analysis based on reported allele frequencies, and are able to recover the ancestral information for each cohort. (III) We propose a new statistic that uses the reported allelic effect sizes and their standard errors to identify significant sample overlap or heterogeneity between pairs of cohorts. (IV) To quantify unknown sample overlap across all pairs of cohorts, we propose a method that uses randomly generated genetic predictors that does not require the sharing of individual-level genotype data and does not breach individual privacy.
The role of volatiles in reactive melt transport in the asthenosphere
Creators: name: Keller, Tobias
name: Katz, Richard F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Experimental studies of mantle petrology find that small concentrations of water and carbon dioxide have a large effect on the solidus temperature and distribution of melting in the upper mantle. However, it has remained unclear what effect small fractions of deep, volatile-rich melts have on melt transport and reactive melting in the shallow asthenosphere. Here we present theory and computations indicating that low-degree, reactive, volatile-rich melts cause channelisation of magmatic flow at depths approximately corresponding to the anhydrous solidus temperature. These results are obtained with a novel method to simulate the thermochemical evolution of the upper mantle in the presence of volatiles. The method uses a thermodynamically consistent framework for reactive, disequilibrium, multi-component melting. It is coupled with a system of equations representing conservation of mass, momentum, and energy for a partially molten grain aggregate. Application of this method in two-phase, three-component upwelling-column models demonstrates that it reproduces leading-order features of hydrated and carbonated peridotite melting; in particular, it captures the production of low-degree, volatile-rich melt at depths far below the volatile-free solidus. The models predict that segregation of volatile-rich, deep melts promotes a reactive channeling instability that creates fast and chemically isolated pathways of melt extraction. Reactive channeling occurs where volatile-rich melts flux the base of the silicate melting region, enhancing dissolution of fusible components from the ambient mantle. We find this effect to be similarly expressed for models of both hydrated and carbonated mantle melting. These findings indicate that despite their small concentrations, water and carbon dioxide have an important control on the extent and style of magma genesis, as well as on the dynamics of melt transport.
description: Revised version of original manuscript titled "Effects of volatiles on melt production and reactive flow in the mantle"
Audouinia esterhuyseniae A. V. Hall 2019, comb. nov.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Audouinia
Audouinia esterhuyseniae

description: Audouinia esterhuyseniae (Powrie) A.V. Hall, comb. nov. ≡ Tittmannia esterhuyseniae Powrie in J. S. African Bot. 35: 363. 1969 – Type: near neck between Kaaimans Gat and Stettyn’s Kloof, ca. 3000 ft, Esterhuysen 32117 (BOL- 136142!, holo).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1145, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses
Creators: name: Herfarth, Hans H.
name: Schaner, Matthew R.
name: Koruda, Mark J.
name: McGovern, Dermot P.
name: Weiser, Matthew
name: Mohlke, Karen L.
name: Lee, Saangyoung E.
name: Sheikh, Shehzad Z.
name: Furey, Terrence S.
name: Simon, Jeremy M.
name: Gipson, Gregory R.
name: Sartor, R. Balfour
name: Sadiq, Timothy S.
name: Lieb, Jason D.
name: Davis, James P.
name: Rahbar, Reza
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Intestinal macrophages are uniquely programmed to tolerate exposure to bacteria without mounting potent inflammatory responses. The cytokine IL-10 maintains the macrophage anti-inflammatory response such that loss of IL-10 results in chronic intestinal inflammation. To investigate how IL-10-deficiency alters intestinal macrophage programming and bacterial tolerance, we studied changes in chromatin accessibility in response to bacteria in macrophages from two distinct niches, the intestine and bone-marrow, from both wild-type and IL-10-deficient mice. In both bone-marrow-derived and intestinal macrophages, we identified chromatin accessibility changes associated with bacterial exposure and IL-10-deficiency. Surprisingly, IL-10-deficient intestinal macrophages adopted chromatin and gene expression patterns characteristic of an inflammatory response, even in the absence of bacteria. Further, if IL-10 protein was added to cells that had previously been IL-10-deficient, it could not revert the chromatin landscape to a normal state. Our results demonstrate that IL-10 deficiency results in stable chromatin alterations in macrophages, even in the absence of bacteria. This supports a model where IL-10-deficiency leads to chromatin alterations that contribute to a loss of intestinal macrophage tolerance to bacteria, which is a primary initiating event in chronic intestinal inflammation.
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: Data sources
Creators: name: Eyre, Max
name: Costa, Federico
name: Ko, Albert
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: rat_data.csv - The cleaned dataset for the rat ecology study. human_data_anon.csv - The cleaned and anonymised dataset for the human cohort study. Please note that household coordinates and valley ID have been removed to ensure participant anonymity. As a result some of the analyses in the R scripts in this repository will not be possible to conduct with this dataset. prediction_grid.csv - The spatial prediction dataset. codebook.pdf - The codebook for datasets. These datasets were collected by and belong to the Instituto de Saúde Coletiva, Universidade Federal da Bahia (ISC-UFBA). Please see https://github.com/maxeyre/Rattiness-infection-framework for a full explanation and R Scripts to conduct the analyses.
When More Means Less Data and Analysis Scripts
Creators: name: Roberson, Jason
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This is the repository for the data, participant log, and analysis scripts used in our registered report titled "When More Means Less: The Impact of Instrumentality Dilution on Evaluations of Romantic Relationships" accepted in-principle at Comprehensive Results in Social Psychology.
Exploring the Experience of Participants Applying a Brief Mindfulness Intervention in Response to Food Cravings for People Engaging in Emotional Eating Behaviour: A Thematic Analysis
Creators: name: Tavoulari, Anna
Publisher: name: University of East London
Year: 2022

description: Food cravings have been associated with several problematic eating behaviours like emotional eating and binge eating. Brief mindfulness-based interventions have been found to be effective in the reduction of food cravings. However, these findings mainly come from quantitative experimental studies and do not capture the subjective experience of the participants using the intervention. This study aimed at exploring the experience of participants applying a brief mindfulness-based intervention for a seven-day practice period in response to food cravings. Ten participants, that self-identified as eating emotionally, listened to a four-minute recording of a mindfulness intervention for seven days every time they experienced a food craving. Data were collected using semi-structured interviews and were analysed using thematic analysis. Four superordinate themes were produced by the analysis ‘The process of applying the mindfulness intervention’, ‘Components at work during the mindfulness intervention’, ‘Effects of the mindfulness intervention’ and ‘Life after’. Each superordinate theme contained several subordinate themes. The results of this study indicated that a brief mindfulness intervention that combines the components of present moment awareness and decentering can have positive effects on food cravings and emotional eating for people who engage in such behaviour. The results of this study suggest that brief mindfulness interventions can be effective and can have a practical application by being easily incorporated into participants’ everyday lives. These results also add to the literature about the effectiveness of brief mindfulness interventions on the reduction of food cravings. These findings could inform clinical practice and the development of effective and targeted brief mindfulness interventions for people engaging in emotional eating.
IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis
Creators: name: Jorgensen, Ine
name: Laufer, Stefan A.
name: Miao, Edward A.
name: Lopez, Joseph P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Inflammasomes activate caspase-1, initiating a lytic form of programmed cell death termed pyroptosis, which is an important innate immune defense mechanism against intracellular infections. We recently demonstrated in a mouse infection model of pyroptosis that instead of releasing bacteria into the extracellular space, bacteria remain trapped within the pyroptotic cell corpse, termed the pore-induced intracellular trap (PIT). This trapping mediates efferocytosis of the PIT and associated bacteria by neutrophils; bacteria are subsequently killed via neutrophil ROS. Using this pyroptosis model, we now show that the pro-inflammatory cytokines IL-1β and IL-18 and inflammatory lipid mediators termed eicosanoids are required for effective clearance of bacteria downstream of pyroptosis. We further show that IL-1β, IL-18, and eicosanoids affect this in part by mediating neutrophil recruitment to the PIT. This is in addition to our prior findings that complement is also important to attract neutrophils. Thus, the PIT initiates a robust and coordinated innate immune response involving multiple mediators that attract neutrophils to efferocytose the PIT and its entrapped bacteria.
Audouinia hispida Class. - Bockh. & E. G. H. Oliv
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Audouinia
Audouinia hispida

description: Audouinia hispida (Pillans) Class.-Bockh. & E.G.H. Oliv., comb. nov. ≡ Tittmannia hispida Pillans in J. S. African Bot. 13: 130. 1947 – Type: Worcester Div.; Brandwacht Mt, 5000 ft. Apr 1929, Stokoe in Bolus Herb. 18936 (BOL- 122174!, holo). Placement of this species in Audouinia is based on morphological data as anther morphology, flower arrangement, presence of pedicels, and presence of cuticular rim; it was not included in the DNA analysis.
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1145, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα + DC function
Creators: name: Tisch, Roland
name: Kroger, Charles J.
name: Wang, Bo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Dysregulation of negative selection contributes to T cell-mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection, however, are ill-defined. Work by our group and others suggest that negative selection is inefficient early in ontogeny and increases with age. This study examines temporal changes in negative selection and the thymic DC compartment. Peptide-induced thymocyte deletion in vivo was reduced in newborn versus 4 wk-old NOD mice, despite a similar sensitivity of the respective thymocytes to apoptosis induction. The temporal increase in negative selection corresponded with an elevated capacity of thymic antigen presenting cells to stimulate T cells, along with altered subset composition and function of resident DC. The frequency of SIRPα+ and plasmacytoid DC (pDC) was increased concomitant with a decrease in CD8α+ DC in 4 wk-old NOD thymi. Importantly, 4 wk-old versus newborn thymic SIRPα+ DC exhibited increased antigen processing and presentation via the MHC class II but not class I pathway, coupled with an enhanced T cell stimulatory capacity not seen in thymic pDC and CD8α+ DC. These findings indicate that the efficiency of thymic DC-mediated negative selection is limited early after birth, and increases with age paralleling expansion of functionally superior thymic SIRPα+ DC.
Empathy toolkit project for primary students
Creators: name: Pickard, Jennifer L.
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Empathy

description: This project identified the reasons why it is essential that educators directly teach the skill of empathy, explored the development of empathy and identified researched based methods for teaching empathy to primary students. Throughout the project, the British Columbia curricular and core competencies were considered and linked to lesson ideas. An empathy toolkit was created for teachers to access when teaching empathy. The toolkit consists of four sections; why it is important to teach empathy, how to integrate empathy lessons on a daily basis, classroom lessons and ways to focus on empathy at a school level.
description: https://viurrspace.ca/bitstream/handle/10613/8668/Pickard.pdf?sequence=4&isAllowed=y
Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection: Innate Immunity
Creators: name: Venkatasubramanian, Sambasivan
name: Welch, Elwyn
name: Paidipally, Padmaja
name: Schechter, Melissa E.
name: Idell, Steven
name: Tvinnereim, Amy R.
name: Jeffers, Ann
name: Tucker, Torry
name: Raghunath, Anjana
name: Cheekatla, Satyanarayana
name: Vankayalapati, Ramakrishna
name: Mackman, Nizel
name: Tripathi, Deepak
name: Andrade, Bruno B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Tissue Factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium tuberculosis (M. tb) infection by using mice lacking the TF gene in myeloid cells (TFΔ) and human monocyte derived macrophages (MDMs). We found that during M. tb infection, a deficiency of TF in myeloid cells was associated with reduced inducible nitric oxide synthase (iNOS) expression, enhanced arginase 1 (Arg1) expression, enhanced IL-10 production and reduced apoptosis in infected macrophages, which augmented M. tb growth. Our results demonstrate that a deficiency of TF in myeloid cells promotes M2 like phenotype in M .tb infected macrophages. A deficiency in TF expression by myeloid cells was also associated with reduced fibrin deposition and increased matrix metalloproteases (MMP)-2 and MMP-9 mediated inflammation in M. tb infected lungs. Our studies demonstrate that TF expressed by myeloid cells has newly recognized abilities to polarize macrophages and to regulate M. tb growth.
2022 Irish Academy of Management (IAM) Annual Conference Trinity College Dublin - An investigation of the personality traits that could identify vulnerable young people who will be susceptible to undue influence by social media influencers (SMIs)
Creators: name: Alves de Castro, Charles
name: OReilly, Isobel
name: Carthy, Aiden
Publisher: name: figshare
Year: 2022
Subjects: subject: 150502 Marketing Communications
subject: FOS: Economics and business
subject: 150506 Marketing Theory

description: The research project “An investigation of the personality traits that could identify vulnerable young people who will be susceptible to undue influence by social media influencers (SMIs)” was presented at 2022 Irish Academy of Management (IAM) Annual ConferenceTrinity College Dublin in the session: Doctoral Colloquium 2022 Irish Academy of Management (IAM) Annual Conference In Person Event, Wednesday 24th August 11am - 1pm.
Polar features in the flagellar propulsion of E. coli bacteria
Creators: name: Bianchi, S.
name: Saglimbeni, F.
name: Lepore, A.
name: Di Leonardo, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: E. coli bacteria swim following a run and tumble pattern. In the run state all flagella join in a single helical bundle that propels the cell body along approximately straight paths. When one or more flagellar motors reverse direction the bundle unwinds and the cell randomizes its orientation. This basic picture represents an idealization of a much more complex dynamical problem. Although it has been shown that bundle formation can occur at either pole of the cell, it is still unclear whether this two run states correspond to asymmetric propulsion features. Using holographic microscopy we record the 3D motions of individual bacteria swimming in optical traps. We find that most cells possess two run states characterised by different propulsion forces, total torque and bundle conformations. We analyse the statistical properties of bundle reversal and compare the hydrodynamic features of forward and backward running states. Our method is naturally multi-particle and opens up the way towards controlled hydrodynamic studies of interacting swimming cells.
Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies
Creators: name: Stookey, Stephanie
name: Cunningham, Tyler
name: Müller, Fabian
name: Pastan, Ira
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: CD22-targeted recombinant immunotoxins (rIT) are active in hairy cell leukemia or acute lymphoblastic leukemia (ALL), but not in mantle cell lymphoma (MCL) patients. The goal was to enhance rIT efficacy in vivo and to define a strong combination treatment. Activity of Moxetumomab pasudotox (Moxe) and LR combined with paclitaxel was tested against MCL cell lines in vitro and as bolus doses or continuous infusion in xenograft models. In the KOPN-8 ALL xenograft, Moxe or paclitaxel alone was active, but all mice died from leukemia; when combined, 60% of the mice achieved a sustained complete remission. Against MCL cells in vitro, LR was more active than Moxe and the cells had to be exposed to rIT for more than 24 hours for them to die. To maintain high blood levels in vivo, LR was administered continuously by 7-day pumps achieving a well-tolerated steady plasma concentration of 45 ng/ml. In JeKo-1 xenografts, continuously administered LR was 14-fold more active than bolus doses and the combination with paclitaxel additionally improved responses by 135-fold. Maintaining high rIT-plasma levels greatly improves responses in the JeKo-1 model and paclitaxel substantially enhances bolus and continuously infused rIT, supporting a clinical evaluation against B-cell malignancies.
"CASUS BELLI" - MODERN SHADES OF GLOBAL OPPOSITION
Creators: name: S.Yu., Kozmenko
Publisher: name: figshare
Year: 2022
Subjects: Geography

description: The article shows the significance of the policy of nuclear deterrence as the main imperative that ensures the exclusion of «casus belli» from the military sphere of global confrontation; however, even non-military instruments of global pressure (sanctions) are capable of inflicting unacceptable damage on the opposing sides. Possible directions of interaction between Russia and China are identified in countering the well-known «Ukrainian» anti-Russian sanctions, as well as possible anti-Chinese sanctions in the aggravation of the geopolitical situation around Taiwan. The narrowing of the export-import economic activities of the two countries under the US sanctions restrictions, as well as the expansion of maritime cooperation using elements of the air- and sea-based nuclear triad, was confirmed.
Audouinia laevis A. V. Hall 2019, comb. nov.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Audouinia
Audouinia laevis

description: Audouinia laevis (Pillans) A.V. Hall, comb. nov. ≡ Tittmannia laevis PillansinJ. S. African Bot. 13: 129. 1947 – Type: Paarl Div.: Winterberg, 5500 ft, Dec 1943, Esterhuysen 9629 (BOL-122077!, holo).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1145, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Teachers’ perceptions and practices regarding Social Emotional Learning (SEL) competencies
Creators: name: Allison, Amber C.
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Anxiety

description: As many as 20% of students suffer from anxiety in educational settings. When social and emotional learning (SEL) competencies are well understood by teachers and taught effectively, these competencies are internalized and used by students to reduce their levels of anxiety. In order for teachers to teach these competencies most effectively, it is important to learn and acknowledge what their personal attitudes and beliefs are regarding SEL, as well as their perceptions of the use of SEL programs in the classroom, their confidence in teaching SEL programs, and the feasibility of SEL programs. Yukon teachers who participated in this survey were asked to provide information surrounding factors that could support continual implementation of an SEL program, as it is critical to understand what motivates teachers to continue using a program. The purpose of this study is to provide recommendations that can create a culture of supporting and promoting teaching of SEL competencies to lower student anxiety.
description: https://viurrspace.ca/bitstream/handle/10613/8669/Allison.pdf?sequence=3&isAllowed=y
elibrary_49248714_35581338.pdf
Creators: name: S.Yu., Kozmenko
Publisher: name: figshare
Year: 2022
Subjects: Geography

description: The article shows the significance of the policy of nuclear deterrence as the main imperative that ensures the exclusion of «casus belli» from the military sphere of global confrontation; however, even non-military instruments of global pressure (sanctions) are capable of inflicting unacceptable damage on the opposing sides. Possible directions of interaction between Russia and China are identified in countering the well-known «Ukrainian» anti-Russian sanctions, as well as possible anti-Chinese sanctions in the aggravation of the geopolitical situation around Taiwan. The narrowing of the export-import economic activities of the two countries under the US sanctions restrictions, as well as the expansion of maritime cooperation using elements of the air- and sea-based nuclear triad, was confirmed.
A culture of learning
Creators: name: Breden, Morgan
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Career development

description: I believe that schools are better places when everyone involved is a learner. This design project has been created with the intention of moving my school towards a culture of ongoing and meaningful professional development, and ultimately developing adaptive expertise. Schools in British Columbia are currently adjusting to the latest revised curriculum and developing mechanisms for teachers to shift their teaching practices to match the new requirements is a necessity. Change is constant in schools and this project has been developed to assist my school in tackling this challenge. The literature on professional development and professional learning communities provided the basis for the design of the project. The literature combined with my current school’s context was used to develop an action plan that provides a map to develop a culture of professional learning. The action plan is designed for a vice-principal or principal to use as a guide to work with staff to shift towards a model of teacher inquiry as professional development. The end goal of the action plan is to develop a culture of professional learning that is supported by leadership, collaboration and inquiry.
description: https://viurrspace.ca/bitstream/handle/10613/8670/Breden.pdf?sequence=3&isAllowed=y
Benchmarking Fast Data Platforms for the Aadhaar Biometric Database
Creators: name: Simmhan, Yogesh
name: Shukla, Anshu
name: Verma, Arun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Aadhaar is the world's largest biometric database with a billion records, being compiled as an identity platform to deliver social services to residents of India.Aadhaar processes streams of biometric data as residents are enrolled and updated.Besides 1 million enrolments and updates per day,up to 100 million daily biometric authentications are expected during delivery of various public services.These form critical Big Data applications,with large volumes and high velocity of data.
description: 9 pages,Preprint:To appear in Seventh Workshop on Big Data Benchmarking (WBDB) proceedings (LNCS )
The effects of emotional labour on teacher identity
Creators: name: Fisk, Marsie L.
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Identity (Psychology)

description: This purpose of this study was to share the experience of mid-career teachers as they continued to develop and understand their personal and professional identities, and to identify how emotional labor impacts identity. Through an online survey inclusive of closed and open-ended questions, participants provided responses that addressed participant demographics, personal and professional identity, and emotional labour in teaching. These findings provided insight into possible structures that support teachers as they navigate and manage the interdependence of personal and professional identities and emotional labour. This research is important to further understand the role of a teacher as the world evolves around us. As the professional responsibilities of teachers in Alberta change to address societal change, it is important to acknowledge changes in classroom demographics, increased complex needs, and increased support initiatives that contribute to teacher stress and a need for teacher wellness. The outcome of this study was expected to provide insight into structures and processes to support teachers in managing emotional labour.
description: https://viurrspace.ca/bitstream/handle/10613/8671/Fisk.pdf?sequence=3&isAllowed=y
Audouinia laxa A. V. Hall 2019, comb. nov.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Audouinia
Audouinia laxa

description: Audouinia laxa (Thunb.) A.V. Hall, comb. nov. ≡ Brunia laxa Thunb., Prodr. Pl. Cap.: 187. 1800 ≡ Tittmannia laxa (Thunb.) C. Presl. in Abh. Königl. Böhm. Ges. Wiss., ser. 5, 3: 462. 1845; PillansinJ. S. African Bot. 13: 128. 1947 – Type: Prom. bonae spei Afr, sine coll. [= Masson] (UPSsheet 5743, holo – microfiche!).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1145, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice
Creators: name: Samulski, R. Jude
name: Johnson, Mark C.
name: Tisch, Roland
name: Manzoor, Fatima
name: Wang, Bo
name: Li, Chengwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: IL-35 is a recently identified cytokine exhibiting potent immunosuppressive properties. The therapeutic potential and effects of IL-35 on pathogenic T effector (Teff) cells and Foxp3+ Treg cells, however, are ill-defined. We tested the capacity of IL-35 to suppress ongoing autoimmunity in NOD mice. For this purpose, an adeno-associated virus vector in which IL-35 transgene expression is selectively targeted to β cells via an insulin promoter (AAV8mIP-IL35) was used. AAV8mIP-IL35 vaccination of NOD mice at a late preclinical stage of type 1 diabetes (T1D) suppressed β-cell autoimmunity and prevented diabetes onset. Numbers of islet-resident conventional CD4+ and CD8+ T cells, and DCs were reduced within 4 weeks of AAV8mIP-IL35 treatment. The diminished islet T-cell pool correlated with suppressed proliferation, and a decreased frequency of IFN-γ-expressing Teff cells. Ectopic IL-35 also reduced islet Foxp3+ Treg-cell numbers and proliferation, and protection was independent of induction/expansion of adaptive islet immunoregulatory T cells. These findings demonstrate that IL-35-mediated suppression is sufficiently robust to block established β-cell autoimmunity, and support the use of IL-35 to treat T1D and other T-cell-mediated autoimmune diseases.
title: FIELD TESTS OF A UAV-COMPATIBLE SPECTROMETER TO EVALUATE ITS SUITABILITY FOR DETAILED SOIL RADON POTENTIAL MAPPING
Creators: name: Thomas, Alexandria
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: classificationCode: 1.5
subject: FOS: Earth and related environmental sciences

description: As part of ongoing research on radionuclide mapping and radon hazard characterization, field tests were performed to evaluate the suitability and limitations of a UAV-compatible gamma spectrometer. To date, this data set includes completed stationary data collection, mobile ground collection, multi-level UAV flights over a known material transition, as well as redundant ground and multi-level UAV data collection over a relatively uniform area. Total counts were used as a measure of soil radionuclide levels for our data collected above background. Although our test sites were in regions underlain by bedrock with high indoor radon levels, uranium counts were barely above background levels. The spectrometer can delineate obvious surface material contrasts (e.g., grass versus asphalt or concrete) analogous to boundaries such as faults juxtaposing different rock units. As the height of the instrument increases above a single surface type, the sensitivity of the spectrometer decreases linearly above the ground while the on-ground footprint increases geometrically. This limits the ability to resolve geologic boundaries. In areas covered by distinctly different surface types, the variation in counts is a function of both altitude and the proportion of each surface type within the footprint of the spectrometer at that location and height. In some cases, height appears to contribute to an increase in counts if the instrument is over a low-count surface material, but the complete spectrometer footprint is dominated by a high-count surface material. Ongoing research will quantify background variability to help identify local variations in a low signal-to-noise (low gamma) environment, including the feasibility of stacking results from multiple single-height flights or profiles to cancel noise and amplify changes across geologic boundaries. Results from multi-level flights will also contribute to our understanding of instrument sensitivity and spatial resolution as functions of flying height.
description: © 2023 Alexandria Thomas
Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives
Creators: name: Liu, Heng
name: Zhu, Gao-Xiang
name: Wang, Mei-Juan
name: Liu, Ying-Qian
name: Wang, Yu-Han
name: Song, Zi-Long
name: Wu, Dan
name: Zhao, Yong-Long
name: Li, Lanlan
name: Wang, Chih-Ya
name: Liu, Huanxiang
name: Morris-Natschke, Susan L.
name: Goto, Masuo
name: Lee, Kuo-Hsiung
name: Yan, Li-Ting
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: 20(S)-Sulfonylamidine CPT-derivatives were prepared and tested for cytotoxicity.Several analogs showed superior cytotoxic activity compared to irinotecan.Key structural features related to cytotoxicity were identified by SAR analysis.Compounds 9 and 15c interacted with Topo I-DNA by a different binding mode from CPT.These compounds are new generation CPT-derived antitumor agents.In an ongoing investigation of 20-sulfonylamidine derivatives (9, YQL-9a) of camptothecin (1) as potential anticancer agents directly and selectively inhibiting topoisomerase (Topo) I, the sulfonylamidine pharmacophore was held constant, and a camptothecin derivatives with various substitution patterns were synthesized. The new compounds were evaluated for antiproliferative activity against three human tumor cell lines, A-549, KB, and multidrug resistant (MDR) KB subline (KBvin). Several analogs showed comparable or superior antiproliferative activity compared to the clinically prescribed 1 and irinotecan (3). Significantly, the 20-sulfonylamidine derivatives exhibited comparable cytotoxicity against KBvin, while 1 and 3 were less active against this cell line. Among them, compound 15c displayed much better cytotoxic activity than the controls 1, 3, and 9. Novel key structural features related to the antiproliferative activities were identified by structure–activity relationship (SAR) analysis. In a molecular docking model, compounds 9 and 15c interacted with Topo I-DNA through a different binding mode from 1 and 3. The sulfonylamidine side chains of 9 and 15c could likely form direct hydrogen bonds with Topo I, while hydrophobic interaction with Topo I and π–π stacking with double strand DNA were also confirmed as binding driving forces. The results from docking models were consistent with the SAR conclusions. The introduction of bulky substituents at the 20-position contributed to the altered binding mode of the compound by allowing them to form new interactions with Topo I residues. The information obtained in this study will be helpful for the design of new derivatives of 1 with most promising anticancer activity.CPT (green), 9 (magenta), and 15c (blue) in the binding site of DNA-Topo-I.
How I use personal stories to build connections in a middle school
Creators: name: Goessman, Corrie L.
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Storytelling

description: What has become my most magnificent skill is my ability to cultivate and create connections between learners within their school community by using their personal stories. I have learned that when a child is free to share his or her own stories they become part of a classroom community, connected to their learning, validated as a person and confident in the classroom. These attributes are necessary for students to succeed at school. As a teacher, I have had to adapt what I am teaching, my routines in the classroom and my personal philosophies in order to create connections between myself and the learners in our school. I have learned to make space and time for learners to have a voice in their classroom, and I have done so through the use of Learning Maps, activities and the development of listening skills. This is an autoethnographic research project designed to draw out and reflect upon the power that learning about the personal lives of each other can have on the relationships in our school. I feel that the results demonstrate the importance of learning to listen, building relationships, and trusting your learning partners.
description: https://viurrspace.ca/bitstream/handle/10613/8672/Goessman.pdf?sequence=3&isAllowed=y
Thamnea Brongn.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Thamnea

description: 3. Thamnea Sol. ex Brongn. in Ann. Sci. Nat. (Paris) 8: 386, t. 38. 1826, nom. cons. (McNeill & al., ICBN: 405. 2006) pro Thamnia P. Browne (Flacourtiaceae); Pillans in J. S. African Bot. 13: 143. 1947 – Type: Thamnea uniflora (L.) Sol. ex Brongn. = Pseudobaeckea Nied. in Engler & Prantl, Nat. Pflanzenfam. 2a: 136. 1891 p.p. quoad P. teres Dümmer. Growth form: ericoid dwarf shrubs, prostrate, often in rock crevices; lignotubers present. Leaves: ± imbricate, sessile, slightly appressed; stipules minute (not seen in T. teres); hypostomatic (epistomatic in T. teres), stomata not surrounded by cuticular rim (except T. teres). Flowers: solitary, sessile (except T. hirtella), on bracteate short shoots with 8–12 bracts (T. teres) or at top of leafy shoots subtended by uppermost involucre-like leaves (remaining species). Petals: free, unguiculate, recurved, white, usuallywithpinklowerhalf (“claw”) or with red stains in lower half (T. teres), pale pink (T. ustulata) or completely pink (T. massoniana), with 2 separate, rather narrow, parallel ridges not fused at base. Scent: occasionally present and sweet (T. massoniana, T. diosmoides). Stamens: included or shortly exserted; anthers linear or linear-oblong, thecae parallel, free only in basal part. Pollen: 3-colporate, except T. ustulata and T. hirtella with 4 or 5 pollen colpi, tectum granular. Ovary: inferior (up to half-inferior in T. teres), 1- or 2-locular with 2–8 ovules per locule, topped by a ring-shaped nectary (not in T. thesioides, T. massoniana, and T. gracilis). Styles: 1 or 2, ± shortly exserted, united (free in T. teres). Fruit: 1-seeded, dry, indehiscent. Habitat: on well-drained soils at high altitudes (>1000 m) with moisture-bearing clouds (T. teres). Flowering time: December–February (T. massoniana), April–July (T. hirtella), October–November (T. teres), or September–November (remaining species). Species: 9 spp.; restricted tomountainslopesinsouth-westernpartof Western Cape.
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1145, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Rethinking learning spaces: how Reggio Emilia environments promote critical thinking
Creators: name: Koop, Jessica L.
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Critical thinking

description: The study explores the historical influences and pedagogical practices of the Reggio Emilia approach to early childhood education, and how particular aspects of its environment work as a third teacher to influence and promote critical thinking. This thesis draws connections between constructivist theory, social constructivism, critical thinking, and the key values and principles of the Reggio Emilia approach. In particular, exploration of the atelier, space, colour, lighting, materials, provocations, and documentation reveals a powerful link between intentional and thoughtful design and the higher order thinking process known as critical thinking. The revised BC curriculum is used to anchor and direct critical thinking as a competency taught and cultivated by teachers. A handbook was created to help Reggio-inspired educators transform their learning environments to reflect Reggio beliefs and to promote the core competency of critical thinking in their classrooms.
description: https://viurrspace.ca/bitstream/handle/10613/8673/Koop.pdf?sequence=4&isAllowed=y
What is our story of collaboration within a distributed leadership team: what is working and why? A look at a cross-curricular team using collaboration to enhance student learning
Creators: name: Lebans, Tanya E.
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: Teams in the workplace

description: Working on a team purposefully formed by formal leaders to better support students’ first year in high school as well as allow team members to work collaboratively to deliver this program inspired me to research the perspective of this B.C. team. This qualitative study was designed to explore the team’s story of collaboration. I used both participant surveys and focus group research to capture the team’s definitions of its successes and challenges. At the same time, the study reviewed the team and formal leaders’ choice to use a distributive leadership model. The literature internationally points to collaboration amongst teachers as a way to help them better meet students’ learning needs, better help support each other’s professional growth and at the same time take risks to innovate their practice to better ensure all students spend the year learning. Moreover, the literature suggests that having teachers take ownership of change helps focus the work on the needs of students and invigorates teachers’ job satisfaction. Such efforts, according to the literature, require a balance between the work of formal leaders and teachers to make collaboration work. Both the survey and focus group data sets along with the researcher’s own field notes were analysed for common themes. Linking the literature to the emerging themes about collaboration and distributive leadership reinforced that such collaborative opportunities, when teacher-driven, enrich student learning and teachers’ excitement for their job. Like all recipes, the team said the prescription for collaboration requires careful attention to subtle details and the overall blend of the ingredients. The researcher noted that the ideas of individual commitment, a common focus on improving learning for students, a chance to innovate and the members comfort with challenges inherent in collaboration drove the success they described.
description: https://viurrspace.ca/bitstream/handle/10613/8674/Lebans.pdf?sequence=3&isAllowed=y
Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells
Creators: name: Yang, Ning-Sun
name: Chen, Yi-Fong
name: Kuo, Sheng-Chu
name: Lin, Yi-Chien
name: Morris-Natschke, Susan L.
name: Lee, Yueh-Hsuan
name: Tseng, Li-Shin
name: Huang, Li-Jiau
name: Lee, Kuo-Hsiung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In our continued focus on 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) analogs, we synthesized a novel series of 3,9-substituted α-carboline derivatives and evaluated the new compounds for antiproliferactive effects. Structure activity relationships revealed that a COOCH or CHOH group at position-3 and substituted benzyl group at position-9 of the α-carboline nucleus were crucial for maximal activity. The most active compound, , showed high levels of cytotoxicity against HL-60, COLO 205, Hep 3B, and H460 cells with IC values of 0.3, 0.49, 0.7, and 0.8 μM, respectively. The effect of compound on the cell cycle distribution demonstrated G2/M arrest in COLO 205 cells. Furthermore, mechanistic studies indicated that compound induced apoptosis by activating death receptor and mitochondria dependent apoptotic signaling pathways in COLO 205 cells. The new 3,9-substituted α-carboline derivatives exhibited excellent anti-proliferative activities, and compound can be used as a promising pro-apoptotic agent for future development of new antitumor agents.