cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of Gas6 in erythropoiesis and anemia in mice
Creators: name: Sugamele, Rocco
name: Burnier, Laurent
name: Izui, Shozo
name: Conway, Edward M.
name: Lambrechts, Diether
name: Fish, Richard J.
name: Goff, Stephen P.
name: Martinez-Soria, Eduardo
name: Schapira, Marc
name: Matsushima, Glenn K.
name: Lemke, Greg
name: Carmeliet, Peter
name: Angelillo-Scherrer, Anne
name: Plaisance, Stéphane
name: Maxwell, Patrick H.
name: Tjwa, Marc
name: DeMol, Maria
name: Collen, Désiré
name: Earp, H. Shelton
name: Chanson, Marc
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Many patients with anemia fail to respond to treatment with erythropoietin (Epo), a commonly used hormone that stimulates erythroid progenitor production and maturation by human BM or by murine spleen. The protein product of growth arrest–specific gene 6 (Gas6) is important for cell survival across several cell types, but its precise physiological role remains largely enigmatic. Here, we report that murine erythroblasts released Gas6 in response to Epo and that Gas6 enhanced Epo receptor signaling by activating the serine-threonine kinase Akt in these cells. In the absence of Gas6, erythroid progenitors and erythroblasts were hyporesponsive to the survival activity of Epo and failed to restore hematocrit levels in response to anemia. In addition, Gas6 may influence erythropoiesis via paracrine erythroblast-independent mechanisms involving macrophages. When mice with acute anemia were treated with Gas6, the protein normalized hematocrit levels without causing undesired erythrocytosis. In a transgenic mouse model of chronic anemia caused by insufficient Epo production, Gas6 synergized with Epo in restoring hematocrit levels. These findings may have implications for the treatment of patients with anemia who fail to adequately respond to Epo.
Fermi Establishes Classical Novae as a Distinct Class of Gamma-Ray Sources
Creators: name: LAT Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A classical nova results from runaway thermonuclear explosions on the surface of a white dwarf that accretes matter from a low-mass main-sequence stellar companion. In 2012 and 2013, three novae were detected in gamma rays and stood in contrast to the first gamma-ray detected nova V407 Cygni 2010, which belongs to a rare class of symbiotic binary systems. Despite likely differences in the compositions and masses of their white dwarf progenitors, the three classical novae are similarly characterized as soft spectrum transient gamma-ray sources detected over 2-3 week durations. The gamma-ray detections point to unexpected high-energy particle acceleration processes linked to the mass ejection from thermonuclear explosions in an unanticipated class of Galactic gamma-ray sources.
description: 34 pages, includes Supplementary Materials; corresponding authors: C.C. Cheung, P. Jean, S.N. Shore
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (57)]
Creators: name: Venturino
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1423
Subjects: subject: Bischofsurkunde
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Venturino de Marni, Bischof von Cremona, ernennt Vincentius de Cipellis, Abt des Benediktinerklosters St. Thomae in Cremona, und Augustinus de Maniis zu seinen Prokuratoren.
Труд как феномен культуры
Creators: name: Спирова Эльвира Маратовна
Publisher: name: Философская школа
Year: 2017
Subjects: ТРУД
КУЛЬТУРА
ПРОТЕСТАНТСКИЙ ЭТОС
КАПИТАЛИЗМ
УСПЕХ
ЗАПАДНАЯ КУЛЬТУРА
РОСТОВЩИЧЕСТВО
ПРАВОСЛАВИЕ
РУССКАЯ КУЛЬТУРА
НЕСТЯЖАТЕЛЬСТВО
LABOR
CULTURE
PROTESTANT
CAPITALISM
SUCCESS
WESTERN CULTURE
USURY
ORTHODOXY
RUSSIAN CULTURE
NOT MONEY-MAKING

description: Труд не является сам по себе безусловной гранью человеческого бытия. Он имеет этот статус только в том случае, когда можно говорить о сохранении человеческой природы, об уникальности человека как особого рода сущего. В протестантской эпохе не просто утверждается достоинство труда и подчёркивается низость праздности. Труд рассматривается как судьба, как призвание человека, как его предназначение. Признаётся богоугодность трудового призвания. В православии, как и в протестантизме, значительное место занимало уважение к труду. Оно благословляло стремление человека сделать этот мир более благоустроенным, соотнесённым и с мирскими потребностями человека. Вместе с тем православие настаивало на великодушии, укреплении достоинства человека. Труд неизменный спутник человеческого бытия. Однако его роль в разных обществах оказывается особой, зависимой от аксиологического измерения конкретной культуры. Сама человеческая активность имеет много уровней, соответственно различен и характер труда, его сложность, его специфика. В любом случае жизнь без труда оказывается пустым, ни к чему не обязывающим существованием.Review. Labor is not in itself an unconditional side of human life. It has this status only in that case when it is possible to tell about preservation of human nature, about uniqueness of the person as special type of real. In a Protestant era the advantage of labor is not just approved and meanness of idleness is emphasized. Labor is considered as destiny, as calling of the person, as his mission. The godly of labor calling admits. In Orthodoxy, as well as in Protestantism, the important place was taken by respect for labor. It blessed the aspiration of the person to make this world more well-planned, correlated with temporal needs of the person. At the same time Orthodoxy insisted on generosity, strengthening of dignity of the person. Labor is an invariable satellite of human life. However its role in different societies appears concrete culture, special, dependent on axiological measurement. Human activity has many levels, also the nature of work, its complexity, its specifics is respectively various. Anyway life without effort appears empty, noncommittal existence.
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
Creators: name: Coffman, Karen
name: Muraoka-Cook, Rebecca S.
name: Fang, Wei Bin
name: Bruckheimer, Elizabeth
name: Zhuang, Guanglei
name: Chen, Jin
name: Hicks, Donna
name: Hwang, Yoonha
name: Brantley-Sieders, Dana M.
name: Cates, Justin M.M.
name: Jackson, Dowdy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis. However, while EphA2 has been reported to enhance tumorigenesis, proliferation, and MAPK activation in several model systems, other studies suggest that EphA2 activation diminishes these processes and inhibits the activity of MAPK upon ligand stimulation. In this study, we eliminated EphA2 expression in 2 transgenic mouse models of mammary carcinoma. EphA2 deficiency impaired tumor initiation and metastatic progression in mice overexpressing ErbB2 (also known as Neu) in the mammary epithelium (MMTV-Neu mice), but not in mice overexpressing the polyomavirus middle T antigen in mammary epithelium (MMTV–PyV-mT mice). Histologic and ex vivo analyses of MMTV-Neu mouse mammary epithelium indicated that EphA2 enhanced tumor proliferation and motility. Biochemical analyses revealed that EphA2 formed a complex with ErbB2 in human and murine breast carcinoma cells, resulting in enhanced activation of Ras-MAPK signaling and RhoA GTPase. Additionally, MMTV-Neu, but not MMTV–PyV-mT, tumors were sensitive to therapeutic inhibition of EphA2. These data suggest that EphA2 cooperates with ErbB2 to promote tumor progression in mice and may provide a novel therapeutic target for ErbB2-dependent tumors in humans. Moreover, EphA2 function in tumor progression appeared to depend on oncogene context, an important consideration for the application of therapies targeting EphA2.
Polarization measurements of the Crab Pulsar with POLAR
Creators: name: Li, Hancheng
name: Collaboration, POLAR
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: POLAR is a dedicated Gamma-Ray Burst polarimeter making use of Compton-scattering which took data from the second Chinese spacelab, the Tiangong-2 from September 2016 to April 2017. It has a wide Field of View of $\sim6$ steradians and an effective area of $\sim400\ cm^2$ at 300 keV. These features make it one of the most sensitive instruments in its energy range (15-500 keV), and therefore capable of almost continuously monitoring persistent sources such as pulsars. Significant folded pulsation from both PSR B0531+21 (the Crab Pulsar) and PSR B1509-58 has been observed. Observations of the Crab Pulsar with POLAR have previously been used for phase-resolved spectroscopy of the Crab Pulsar to calibrate the instrumental responses of POLAR. In this work, we investigate a polarimetric joint-fitting method for observations of the Crab Pulsar with POLAR. Unlike a GRB observation with POLAR, the observations of the Crab Pulsar are complicated by multiple observational datasets during which the polarization plane rotates as well. So before fitting, we have to correct the modulation curves under different datasets, by taking into account the rotations of the Crab Pulsar's relative position in the detctor's local coordinate, and the changes of detector response in different datasets. Despite these difficulties and the low signal to background for such sources constraining, polarization measurements were possible with the POLAR data. We will present the methodology briefly, which could be applied to any wide FoV polarimeter, and polarization results of the Crab pulsar with POLAR. Finally, the inferred ability of pulsar detection with POLAR-2 (the successor of POLAR) will also be discussed.
description: 8 pages, 7 figures, 2 tables, 37th International Cosmic Ray Conference (ICRC2021) proceedings
The spread, treatment, and prevention of HIV-1: evolution of a global pandemic
Creators: name: Levy, Jay A.
name: Hellmann, Nick
name: Lange, Joep
name: Cohen, Myron S.
name: DeCock, Kevin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The most up-to-date estimates demonstrate very heterogeneous spread of HIV-1, and more than 30 million people are now living with HIV-1 infection, most of them in sub-Saharan Africa. The efficiency of transmission of HIV-1 depends primarily on the concentration of the virus in the infectious host. Although treatment with antiviral agents has proven a very effective way to improve the health and survival of infected individuals, as we discuss here, the epidemic will continue to grow unless greatly improved prevention strategies can be developed and implemented. No prophylactic vaccine is on the horizon. However, several behavioral and structural strategies have made a difference — male circumcision provides substantial protection from sexually transmitted diseases, including HIV-1, and the application of antiretroviral agents for prevention holds great promise.
Systematic KMTNet Planetary Anomaly Search, Paper VII: Complete Sample of $q < 10^{-4}$ Planets from the First Four-Year Survey
Creators: name: Zang, Weicheng
name: Jung, Youn Kil
name: Yang, Hongjing
name: Zhang, Xiangyu
name: Udalski, Andrzej
name: Yee, Jennifer C.
name: Gould, Andrew
name: Mao, Shude
name: Albrow, Michael D.
name: Chung, Sun-Ju
name: Han, Cheongho
name: Hwang, Kyu-Ha
name: Ryu, Yoon-Hyun
name: Shin, In-Gu
name: Shvartzvald, Yossi
name: Cha, Sang-Mok
name: Kim, Dong-Jin
name: Kim, Hyoun-Woo
name: Kim, Seung-Lee
name: Lee, Chung-Uk
name: Lee, Dong-Joo
name: Lee, Yongseok
name: Park, Byeong-Gon
name: Pogge, Richard W.
name: Mróz, Przemek
name: Skowron, Jan
name: Poleski, Radoslaw
name: Szymański, Michał K.
name: Soszyński, Igor
name: Pietrukowicz, Paweł
name: Kozłowski, Szymon
name: Ulaczyk, Krzysztof
name: Rybicki, Krzysztof A.
name: Iwanek, Patryk
name: Wrona, Marcin
name: Gromadzki, Mariusz
name: Wang, Hanyue
name: Zhang, Jiyuan
name: Zhu, Wei
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the analysis of seven microlensing planetary events with planet/host mass ratios $q < 10^{-4}$: KMT-2017-BLG-1194, KMT-2017-BLG-0428, KMT-2019-BLG-1806, KMT-2017-BLG-1003, KMT-2019-BLG-1367, OGLE-2017-BLG-1806, and KMT-2016-BLG-1105. They were identified by applying the Korea Microlensing Telescope Network (KMTNet) AnomalyFinder algorithm to 2016--2019 KMTNet events. A Bayesian analysis indicates that all the lens systems consist of a cold super-Earth orbiting an M or K dwarf. Together with 17 previously published and three that will be published elsewhere, AnomalyFinder has found a total of 27 planets that have solutions with $q < 10^{-4}$ from 2016--2019 KMTNet events, which lays the foundation for the first statistical analysis of the planetary mass-ratio function based on KMTNet data. By reviewing the 27 planets, we find that the missing planetary caustics problem in the KMTNet planetary sample has been solved by AnomalyFinder. We also find a desert of high-magnification planetary signals ($A \gtrsim 65$), and a follow-up project for KMTNet high-magnification events could detect at least two more $q < 10^{-4}$ planets per year and form an independent statistical sample.
description: AJ in press
Chromosome maps of Globular Clusters from wide-field ground-based photometry
Creators: name: Jang, S.
name: Milone, A. P.
name: Legnardi, M. V.
name: Marino, A. F.
name: Mastrobuono-Battisti, A.
name: Dondoglio, E.
name: Lagioia, E. P.
name: Casagrande, L.
name: Carlos, M.
name: Mohandasan, A.
name: Cordoni, G.
name: Bortolan, E.
name: Lee, Y. -W.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Hubble Space Telescope (HST) photometry is providing an extensive analysis of globular clusters (GCs). In particular, the pseudo two-colour diagram dubbed 'chromosome map (ChM)' allowed to detect and characterize their multiple populations with unprecedented detail. The main limitation of these studies is the small field of view of HST, which makes it challenging to investigate some important aspects of the multiple populations, such as their spatial distributions and the internal kinematics in the outermost cluster regions. To overcome this limitation, we analyse state-of-art wide-field photometry of 43 GCs obtained from ground-based facilities. We derived high-resolution reddening maps and corrected the photometry for differential reddening when needed. We use photometry in the U, B, and I bands to introduce the $Δc_{\rm U,B,I}$ vs. $Δ_{\rm B,I}$ ChM of red-giant branch (RGB) and asymptotic-giant branch (AGB) stars. We demonstrate that this ChM, which is built with wide-band ground-based photometry, is an efficient tool to identify first- and second-generation stars (1G and 2G) over a wide field of view. To illustrate its potential, we derive the radial distribution of multiple populations in NGC 288 and infer their chemical composition. We present the ChMs of RGB stars in 29 GCs and detect a significant degree of variety. The fraction of 1G and 2G stars, the number of subpopulations, and the extension of the ChMs significantly change from one cluster to another. Moreover, the metal-poor and metal-rich stars of Type II GCs define distinct sequences in the ChM. We confirm the presence of extended 1G sequences.
description: 19 pages, 15 figures
О содержании «Трансцендентной эстетики» И. Канта
Creators: name: Труфанов Сергей Николаевич
Publisher: name: Философская школа
Year: 2017
Subjects: ТРАНСЦЕНДЕНТАЛЬНАЯ ЭСТЕТИКА
И. КАНТ
ПОЗНАНИЕ
СОЗЕРЦАНИЕ
МЫШЛЕНИЕ
РАССУДОК
ПРОСТРАНСТВО
ВРЕМЯ
ОПЫТ
"TRANSCENDENTAL AESTHETICS"
I. KANT
COGNITION
CONTEMPLATION
THINKING
MIND
SPACE
TIME
EXPERIENCE

description: В статье рассматривается структура «Критики чистого разума» И. Канта и даётся авторский вариант доступного изложения содержания её первого раздела «Трансцендентальной эстетики».Review. The paper deals with the structural characteristics of «Pure Mind Criticizm» by I. Kant. The author offers his own accessible variation of its first section «Transcendental Aesthetics».
The sensitivity of pulsar timing arrays
Creators: name: Moore, Christopher J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Simple analytic expressions are derived for the sensitivity curve of a pulsar timing array (PTA) to both a monochromatic source of gravitational waves and an isotropic stochastic background of gravitational waves. These derivations are performed in both frequentist and Bayesian frameworks and the results verified with numerical injections and recovery in mock PTA datasets. The consistency of the frequentist and Bayesian approaches is demonstrated and the results are used to emphasise the fact that the sensitivity curve of a PTA depends not only on the properties of the PTA itself, but also on the properties of the gravitational wave source being observed.
description: 7 pages, 4 figures, CONFERENCE PROCEEDINGS 10th International LISA Symposium
Lorentz- and CPT-violating neutrinos from string/D-brane model
Creators: name: Li, Chengyi
name: Ma, Bo-Qiang
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show that the space-time foam model from string/D-brane theory predicts a scenario in which neutrinos can possess linearly energy dependent speed variation, together with an asymmetry between neutrinos and antineutrinos, indicating the possibility of Lorentz and CPT symmetry violation for neutrinos. Such scenario is supported by a phenomenological conjecture from the possible associations of IceCube ultrahigh-energy neutrino events with the gamma-ray bursts. It is also consistent with the constraints set by the energy-losing decay channels~(e.g., $e^{+}e^{-}$ pair emission, or neutrino splitting) upon superluminal neutrino velocities. We argue that the plausible violations of energy-momentum conservation during decay may be responsible for the stable propagation of these neutrinos, and hence for the evasion of relevant constraints.
description: 5 latex pages, final version for journal publication
Machine learning assisted coarse-grained molecular dynamics modeling of meso-scale interfacial fluids
Creators: name: Ge, Pei
name: Zhang, Linfeng
name: Lei, Huan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A hallmark of meso-scale interfacial fluids is the multi-faceted, scale-dependent interfacial energy, which often manifests different characteristics across the molecular and continuum scale. The multi-scale nature imposes a challenge to construct reliable coarse-grained (CG) models, where the CG potential function needs to faithfully encode the many-body interactions arising from the unresolved atomistic interactions and account for the heterogeneous density distributions across the interface. We construct the CG models of both single- and two-component of polymeric fluid systems based on the recently developed deep coarse-grained potential (DeePCG) scheme, where each polymer molecule is modeled as a CG particle. By only using the training samples of the instantaneous force under the thermal equilibrium state, the constructed CG models can accurately reproduce both the probability density function of the void formation in bulk and the spectrum of the capillary wave across the fluid interface. More importantly, the CG models accurately predict the volume-to-area scaling transition for the apolar solvation energy, illustrating the effectiveness to probe the meso-scale collective behaviors encoded with molecular-level fidelity.
Semantic 3D Grid Maps for Autonomous Driving
Creators: name: Khoche, Ajinkya
name: Wozniak, Maciej K
name: Duberg, Daniel
name: Jensfelt, Patric
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Maps play a key role in rapidly developing area of autonomous driving. We survey the literature for different map representations and find that while the world is three-dimensional, it is common to rely on 2D map representations in order to meet real-time constraints. We believe that high levels of situation awareness require a 3D representation as well as the inclusion of semantic information. We demonstrate that our recently presented hierarchical 3D grid mapping framework UFOMap meets the real-time constraints. Furthermore, we show how it can be used to efficiently support more complex functions such as calculating the occluded parts of space and accumulating the output from a semantic segmentation network.
description: Submitted, accepted and presented at the 25th IEEE International Conference on Intelligent Transportation Systems (IEEE ITSC 2022)
Novel description of $P_c(4312)^+$, $P_c(4380)^+$, and $P_c(4457)^+$ with double triangle cusps
Creators: name: Nakamura, Satoshi X.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose a novel scenario for the peak structures, usually interpreted as hidden charm pentaquark ($P_c$) contributions, in the LHCb's $Λ_b^0\to J/ψp K^-$ data. The key idea is to utilize leading or lower-order singularities from double triangle mechanisms. The singularities cause anomalous threshold cusps, which are significantly more singular than the ordinary ones, at the $Σ_c^{(*)}\bar{D}^{(*)}$ threshold. We demonstrate that the double triangle amplitudes interfere with other common mechanisms to create peak structure that fit well the $P_c(4312)^+$, $P_c(4380)^+$, and $P_c(4457)^+$ peaks in the data. This picture is completely different from commonly used ones such as hadron molecules and compact pentaquarks. Meanwhile, $P_c(4440)^+$ is included in the proposed model as a resonance with width and strength significantly smaller than previously estimated. The proposed model can (partly) explain the current data for other processes where $P_c^+$ signals are expected such as: no $P_c^+$ signals in the GlueX $J/ψ$ photoproduction data; a possible signal only from $P_c(4440)^+$ in the LHCb's $Λ_b^0\to J/ψp π^-$ data.
description: 6 pages, 4 figures, Contribution to the Proceedings for 10th International Workshop on Charm Physics (CHARM 2020), May 31-June 5 2021, Mexico City, Mexico
Иерусалимские свитки: исторические фантазии на евангельские сюжеты
Creators: name: Пекелис Михаил Абрамович
Publisher: name: Философская школа
Year: 2017
Subjects: ИИСУС ХРИСТОС
БЛАГАЯ ВЕСТЬ
СИНЕДРИОН
ПОНТИЙ ПИЛАТ
НИКОДИМ
ИОАНН КРЕСТИТЕЛЬ
ИОСИФ
ВЕРА
ИСТИНА
РАСПЯТИЕ
JESUS CHRIST
GOOD NEWS
COUNCIL
PONTIUS PILATE
NICODEMUS
JOHN THE BAPTIST
IOSIF
BELIEF
TRUTH
CRUCIFIXION

description: Евангельские темы пронизывают всю русскую поэзию чуть ли не с момента Крещения Руси. Со временем философское значение Учения Христа только возрастает. В настоящей работе известного московского поэта и философа Михаила Пластова представлено философско-поэтическое осмысление Евангельских сюжетов.Review. Evangelical subjects penetrate all Russian poetry nearly from the moment of the Baptism of Rus'. Over time philosophical value of the Doctrine of Christ only increases. In the work of the famous Moscow poet and philosopher Michael Plastov philosophical and poetic judgment of Evangelical plots is presented.
Spitzer Local Volume Legacy (LVL) SEDs and Physical Properties
Creators: name: Cook, David O.
name: Dale, Daniel A.
name: Johnson, Benjamin D.
name: Van Zee, Liese
name: Lee, Janice C.
name: Kennicutt, Robert C.
name: Calzetti, Daniela
name: Staudaher, Shawn M.
name: Engelbracht, Charles W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the panchromatic spectral energy distributions (SEDs) of the Local Volume Legacy (LVL) survey which consists of 258 nearby galaxies ($D
description: Accepted for publication in MNRAS (15 pages, 14 figures, 1 table)
Status and recent extensions of the Caribou DAQ System for picosecond timing
Creators: name: Buschmann, Eric
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Caribou is a flexible open-source DAQ system developed and used within several collaborative frameworks (CERN EP R&D, RD50, AIDAinnova) for laboratory and high-rate beam tests and easy integration of new silicon-pixel detector prototypes. It uses common hardware, firmware and software components that are shared across different projects, thereby reducing the development effort and cost for such readout systems significantly. This contribution introduces the FASTPIX, APTS and DPTS detectors recently integrated in Caribou and their requirements in terms of waveform sampling and timing of digital pulses. A Time-to-Digital-Converter implemented in the Caribou FPGA was developed to overcome the limitations of the previously used oscilloscope-based readout. It allows for precision timing over large time spans required for the Time-of-Arrival, Time-over-Threshold, and position encoding used in the FASTPIX and DPTS test chips with asynchronous digital readout. A time resolution after calibration of better than 10 ps is achieved.
description: TWEPP 2022 proceedings
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
Creators: name: Sestu, Natascia
name: Saxena, Richa
name: Smith, George Davey
name: Duren, William L.
name: Sanna, Serena
name: Saramies, Jouko
name: Lawlor, Debbie A.
name: Hansen, Torben
name: Chen, Wei-Min
name: Grazia Piras, Maria
name: Ben-Shlomo, Yoav
name: Stringham, Heather M.
name: Willer, Cristen J.
name: Ebrahim, Shah
name: Timpson, Nicholas J.
name: Borch-Johnsen, Knut
name: Lyssenko, Valeriya
name: Kuusisto, Johanna
name: Jørgensen, Torben
name: Silver, Kristi D.
name: Erdos, Michael R.
name: Jackson, Anne U.
name: Swift, Amy J.
name: Najjar, Samer
name: Spada, Maria Cristina
name: Scott, Laura J.
name: Mitchell, Braxton D.
name: Orrù, Marco
name: Olla, Nazario
name: Andersen, Gitte
name: Shen, Haiqing
name: Bonnycastle, Lori L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 × 10–7). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 × 10–26, and combining results from all studies resulted in an overall P value for association of 6.4 × 10–33. Across these studies, fasting glucose concentrations increased 0.01–0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.
Философские аспекты учения о ноосфере и проблемы развития мировой цивилизации
Creators: name: Шильнов Александр Александрович
Publisher: name: Философская школа
Year: 2017
Subjects: ФИЛОСОФИЯ
PHILOSOPHY
РЕЛИГИЯ
RELIGION
ЭКОЛОГИЯ
ECOLOGY
В. И. ВЕРНАДСКИЙ
V. I. VERNADSKY
БИОСФЕРА
BIOSPHERE
НООСФЕРА
NOOSPHERE
ЦИВИЛИЗАЦИЯ
CIVILIZATION
ЧЕЛОВЕЧЕСТВО
MANKIND
НАУЧНАЯ МЫСЛЬ
SCIENTIFIC MIND
ПРИРОДНЫЙ ЛАНДШАФТ
NATURAL LANDSCAPE

description: В связи с угрозой глобальной экологической катастрофы, проблема сохранения мира и человечества выходит на передний план размышлений философов и учёных. При этом значительный интерес представляет анализ взаимосвязи философии, религии и экологии. Религия, философия и экология пытаются найти ответ на вопрос о том, что необходимо предпринять для сохранения жизни на Земле. В статье подробно рассматриваются основные положения, сильные стороны и противоречия столь сложного, оригинального и неоднозначного учения В. И. Вернадского о биосфере и переходе её в новое качество ноосферу, где тесно переплелись современные философские, научные и религиозные концепции.Review. Due to the threat of a global environmental disaster, the problem of preservation of peace and mankind moves to the forefront of reflections of philosophers and scientists. At the same time the analysis of interrelation of philosophy, religion and ecology is of considerable interest. The religion, philosophy and ecology try to find the answer to a question of what needs to be undertaken for preservation of life on Earth. The article considers basic provisions, strengths and contradictions of so difficult, original and ambiguous doctrine of V. I. Vernadsky about the biosphere and its transition to new quality that is a noosphere where modern philosophical, scientific and religious concepts closely intertwined in detail.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (58)]
Creators: name: Andrinus De Piscatoribus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1423
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Andrinus de Piscatoribus, Sohn des verstorbenen Filiponus, bestellt in Rechtsstreitigkeiten zwischen Johannes Bruxatus, Sohn des verstorbenen Baldesarrus Bruxatus, auf der einen und Michelonus de Piscatoribus, Sohn des verstorbenen Filipus, sowie Obriginus Grita, Sohn des verstorbenen Francinus Grita, und weiteren genannten Personen auf der anderen Seite den Filipus de Cazis, Doktor der Rechte und Sohn des verstorbenen Jacobus, seinerseits magister grammaticae, und Johannes de Uellate, Doktor der Rechte und Sohn des Baldesarrus, seinerseits Doktor der Rechte, und weitere genannte Personen, zu Schiedsrichtern. Es folgt ein weiterer Rechtsakt, in dem ein Kompromiss in den Streitigkeiten erzielt wird.
Accelerated projected gradient algorithms for sparsity constrained optimization problems
Creators: name: Alcantara, Jan Harold
name: Lee, Ching-pei
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: We consider the projected gradient algorithm for the nonconvex best subset selection problem that minimizes a given empirical loss function under an $\ell_0$-norm constraint. Through decomposing the feasible set of the given sparsity constraint as a finite union of linear subspaces, we present two acceleration schemes with global convergence guarantees, one by same-space extrapolation and the other by subspace identification. The former fully utilizes the problem structure to greatly accelerate the optimization speed with only negligible additional cost. The latter leads to a two-stage meta-algorithm that first uses classical projected gradient iterations to identify the correct subspace containing an optimal solution, and then switches to a highly-efficient smooth optimization method in the identified subspace to attain superlinear convergence. Experiments demonstrate that the proposed accelerated algorithms are magnitudes faster than their non-accelerated counterparts as well as the state of the art.
description: 33 pages
Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
Creators: name: Vasievich, Matthew P.
name: Kim, Hyung-Suk
name: Gould, Samantha K.
name: Barisoni, Laura
name: Pisetsky, David S.
name: Coffman, Thomas M.
name: Tran, Trinh T.
name: Jeansson, Marie
name: Prieto-Carrasquero, Minolfa C.
name: Foster, Mary H.
name: Ruiz, Phillip
name: Parsons, Kelly K.
name: Chen, Benny J.
name: Facemire, Carie
name: Crowley, Steven D.
name: Pazmino, A. Kathy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Studies in humans and animal models indicate a key contribution of angiotensin II to the pathogenesis of glomerular diseases. To examine the role of type 1 angiotensin (AT1) receptors in glomerular inflammation associated with autoimmune disease, we generated MRL-Faslpr/lpr (lpr) mice lacking the major murine type 1 angiotensin receptor (AT1A); lpr mice develop a generalized autoimmune disease with glomerulonephritis that resembles SLE. Surprisingly, AT1A deficiency was not protective against disease but instead substantially accelerated mortality, proteinuria, and kidney pathology. Increased disease severity was not a direct effect of immune cells, since transplantation of AT1A-deficient bone marrow did not affect survival. Moreover, autoimmune injury in extrarenal tissues, including skin, heart, and joints, was unaffected by AT1A deficiency. In murine systems, there is a second type 1 angiotensin receptor isoform, AT1B, and its expression is especially prominent in the renal glomerulus within podocytes. Further, expression of renin was enhanced in kidneys of AT1A-deficient lpr mice, and they showed evidence of exaggerated AT1B receptor activation, including substantially increased podocyte injury and expression of inflammatory mediators. Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression. Since AT1A-deficient lpr mice had low blood pressure, these findings suggest that activation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and inflammation in the absence of hypertension.
Non-thermal emission from young supernova remnants in dense circumstellar environments
Creators: name: Brose, Robert
name: Mackey, Jonathan
name: Sushch, Iurii
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Supernova remnants are known to accelerate cosmic rays (CRs) on account of their non-thermal emission of radio waves, X-rays, and gamma rays. However, the ability to accelerate CRs up to PeV-energies has yet to be demonstrated. The presence of cut-offs in the gamma-ray spectra of several young SNRs led to the idea that PeV energies might only be achieved during the very initial stages of a remnant's evolution. We use the time-dependent acceleration code RATPaC to study the acceleration of cosmic rays in supernovae expanding into dense environments around massive stars, where the plentiful target material might offer a path to the detection of gamma-rays by current and future experiments. We performed spherically symmetric 1-D simulations in which we simultaneously solve the transport equations for cosmic rays, magnetic turbulence, and the hydrodynamical flow of the thermal plasma in the test-particle limit. We investigated typical parameters of the circumstellar medium (CSM) in the freely expanding winds around red supergiant (RSG) and luminous blue variable (LBV) stars. The maximum achievable energy might be limited to sub-PeV energies despite strong magnetic fields close to the progenitor star that enhance turbulence-damping by cascading: we find a maximum CR energy of 100-200 TeV, reached within one month after explosion. The peak luminosity for a LBV progenitor is 1e43 erg/s (1e42 erg/s) at GeV (TeV) energies and, for a RSG progenitor, 1e41 erg/s (1e40 erg/s). All calculated SNe reach their peak gamma-ray luminosity after <~1 month and then fade at a rate ~1/t as long as the SN shock remains in the freely expanding wind of the progenitor. Potentially detectable gamma-ray signals can be expected in the Fermi-LAT waveband weeks to months after an explosion into a freely expanding wind.
description: 8 pages, 4 figures, Contribution to the Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), Berlin, Germany
Методологические и практические вопросы конкурентоспособности управленчесого персонала
Creators: name: Шаповалов Владимир Иванович
Publisher: name: Философская школа
Year: 2017
Subjects: КОНКУРЕНТОСПОСОБНОСТЬ РУКОВОДИТЕЛЯ
ЧЕЛОВЕЧЕСКИЙ ФАКТОР
МЕНЕДЖМЕНТ
СИСТЕМНЫЙ ПОДХОД
КЛАССИФИКАЦИЯ КОНЦЕПЦИЙ УПРАВЛЕНИЯ ПЕРСОНАЛОМ
ТИПЫ КОНКУРЕНТОСПОСОБНОСТИ
КОМПЕТЕНТНОСТНЫЙ ПОДХОД
МОДЕЛЬ КОНКУРЕНТОСПОСОБНОСТИ
ИНДЕКС КОНКУРЕНТОСПОСОБНОСТИ
ИНТЕГРАЛЬНЫХ КАЧЕСТВА КОНКУРЕНТОСПОСОБНОСТИ
COMPETITIVENESS OF THE CHIEF
HUMAN FACTOR
MANAGEMENT
SYSTEM APPROACH
CLASSIFICATION OF CONCEPTS OF HUMAN RESOURCE MANAGEMENT
COMPETITIVENESS TYPES
COMPETENCE-BASED APPROACH
COMPETITIVENESS MODEL
INDEX OF COMPETITIVENESS
INTEGRATED QUALITIES OF COMPETITIVENESS

description: Рассматриваются теоретические и практические вопросы формирования конкурентоспособности руководителя. Актуальность совершенствования конкурентоспособности управленческого персонала обеспечивается тем, что руководитель (менеджер) является решающим фактором эффективного функционирования организации, что отражается в стратегической политике управления. В статье предлагается теоретическая модель, основанная на системной взаимосвязи двух направленностей руководителя: на дело (профессиональные компетенции) и на людей (социальные компетенции), проявляющихся в конкурентоспособности руководителя в их системном единстве. В практическом плане выделяются сущностные (интегральные) признаки конкурентоспособности; приводится схема расчет индекса конкурентоспособности и диаграмма, отображающая интегральные качества высокого, среднего и низкого индексов конкурентоспособности руководителя.Review. The article describes theoretical and practical questions of formation of competitiveness of the chief. Relevance of improvement of competitiveness of administrative personnel is provided that the chief is decisive factor of effective functioning of the organization that is reflected in strategic policy of management. In article the theoretical model based on system interrelation of two orientations of the chief is offered: on business (professional competences) and on the people (social competences) who are shown in competitiveness of the chief in their system unity. Intrinsic (integrated) signs of competitiveness are on the practical level allocated; the scheme calculation of an index of competitiveness and the chart displaying integrated qualities of high, average and low indexes of competitiveness of the chief is provided.
Effects of spin-orbit coupling and in-plane Zeeman fields on the critical current in two-dimensional hole gas SNS junctions
Creators: name: Lidal, Jonas
name: Danon, Jeroen
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Superconductor--semiconductor hybrid devices are currently attracting much attention, fueled by the fact that strong spin--orbit interaction in combination with induced superconductivity can lead to exotic physics with potential applications in fault-tolerant quantum computation. The detailed nature of the spin dynamics in such systems is, however, often strongly dependent on device details and hard to access in experiment. In this paper we theoretically investigate a superconductor--normal--superconductor junction based on a two-dimensional hole gas with additional Rashba spin orbit--coupling, and we focus on the dependence of the critical current on the direction and magnitude of an applied in-plane magnetic field. We present a simple model, which allows us to systematically investigate different parameter regimes and obtain both numerical results and analytical expressions for all limiting cases. Our results could serve as a tool for extracting more information about the detailed spin physics in a two-dimensional hole gas based on a measured pattern of critical currents.
description: 11 pages, 5 figures
Quadrupolar Singlet Ground State of Praseodymium in a Modulated Pyrochlore
Creators: name: van Duijn, J.
name: Kim, K. H.
name: Hur, N.
name: Adroja, D. T.
name: Bridges, F.
name: Daoud-Aladine, A.
name: Fernandez-Alonso, F.
name: Ruiz-Bustos, R.
name: Wen, J.
name: Kearney, V.
name: Huang, Q. Z.
name: Cheong, S. -W.
name: Nakatsuji, S.
name: Broholm, C.
name: Perring, T. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The complex structure and magnetism of Pr$_{2-x}$Bi$_x$Ru$_2$O$_7$ was investigated by neutron scattering and EXAFS. Pr has an approximate doublet ground-state and the first excited state is a singlet. This overall crystal field level scheme is similar to metallic Pr$_2$Ir$_2$O$_7$, which is also reported here. While the B-site (Ru) is well ordered throughout, this is not the case for the A-site (Pr/Bi). A distribution of the Pr-O2 bond length indicates the Pr environment is not uniform even for $x=0$. The Bi environment is highly disordered ostensibly due to the 6s lone pairs on Bi$^{3+}$. Correspondingly we find the non-Kramers doublet ground state degeneracy otherwise anticipated for Pr in the pyrochlore structure is lifted so as to produce a quadrupolar singlet ground state with a spatially varying energy gap. For $x=0$, below T$_N$, the Ru sublattice orders antiferromagnetically, with propagation vector \textbf{k}= (0,0,0), as for Y$_2$Ru$_2$O$_7$. No ordering associated with the Pr sublattice is observed down to 100 mK. The low energy magnetic response of Pr$_{2-x}$Bi$_x$Ru$_2$O$_7$ features a broad spectrum of magnetic excitations associated with inhomogeneous splitting of the Pr quasi-doublet ground state. For $x=0$ ($x=0.97$) the spectrum is temperature dependent (independent). It appears disorder associated with Bi alloying enhances the inhomogeneous Pr crystal field level splitting so that inter-site interactions become irrelevant for $x=0.97$. The structural complexity for the A-site may be reflected in the hysteretic uniform magnetization of B-site ruthenium in the Néel phase.
description: 20 pages, 21 figures, submitted to PRB
Bayesian dose-response analysis for epidemiological studies with complex uncertainty in dose estimation
Creators: name: Kwon, Deukwoo
name: Hoffman, F. Owen
name: Moroz, Brian E.
name: Simon, Steven L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Most conventional risk analysis methods rely on a single best estimate of exposure per person which does not allow for adjustment for exposure-related uncertainty. Here, we propose a Bayesian model averaging method to properly quantify the relationship between radiation dose and disease outcomes by accounting for shared and unshared uncertainty in estimated dose. Our Bayesian risk analysis method utilizes multiple realizations of sets (vectors) of doses generated by a two-dimensional Monte Carlo simulation method that properly separates shared and unshared errors in dose estimation. The exposure model used in this work is taken from a study of the risk of thyroid nodules among a cohort of 2,376 subjects following exposure to fallout resulting from nuclear testing in Kazakhstan. We assessed the performance of our method through an extensive series of simulation tests and comparisons against conventional regression risk analysis methods. We conclude that when estimated doses contain relatively small amounts of uncertainty, the Bayesian method using multiple realizations of possibly true dose vectors gave similar results to the conventional regression-based methods of dose-response analysis. However, when large and complex mixtures of shared and unshared uncertainties are present, the Bayesian method using multiple dose vectors had significantly lower relative bias than conventional regression-based risk analysis methods as well as a markedly increased capability to include the pre-established 'true' risk coefficient within the credible interval of the Bayesian-based risk estimate. An evaluation of the dose-response using our method is presented for an epidemiological study of thyroid disease following radiation exposure.
HIF2alpha cooperates with RAS to promote   lung tumorigenesis in mice.
Creators: name: Hayes, D. Neil
name: Jackson, Autumn L.
name: Kaelin, William G.
name: Brandstetter, Kathleyn A.
name: Ospina, Beatriz
name: Zhou, Bing
name: Weigman, Victor J.
name: Nikolinakos, Petros
name: Wong, Kwok-Kin
name: Naumov, George
name: Sharpless, Norman E.
name: Padera, Robert F.
name: Kung, Andrew L.
name: Carretero, Julian
name: Yeh, Jen Jen
name: Heathcote, Samuel A.
name: Heymach, John V.
name: Perera, Samanthi
name: Zaghlul, Sara
name: Kim, William Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non-small cell lung cancer (NSCLC), high HIF2alpha levels correlate with decreased overall survival, and inhibition of either the protein encoded by the canonical HIF target gene VEGF or VEGFR2 improves clinical outcomes. However, whether HIF2alpha is causal in imparting this poor prognosis is unknown. Here, we generated mice that conditionally express both a nondegradable variant of HIF2alpha and a mutant form of Kras (KrasG12D) that induces lung tumors. Mice expressing both Hif2a and KrasG12D in the lungs developed larger tumors and had an increased tumor burden and decreased survival compared with mice expressing only KrasG12D. Additionally, tumors expressing both KrasG12D and Hif2a were more invasive, demonstrated features of epithelial- mesenchymal transition (EMT), and exhibited increased angiogenesis associated with mobilization of circulating endothelial progenitor cells. These results implicate HIF2alpha causally in the pathogenesis of lung cancer in mice, demonstrate in vivo that HIF2alpha can promote expression of markers of EMT, and define HIF2alpha as a promoter of tumor growth and progression in a solid tumor other than renal cell carcinoma. They further suggest a possible causal relationship between HIF2alpha and prognosis in patients with NSCLC.