cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Essential Tremor Prevalence Is Low in the Druze Population in Northern Israel
Creators: Aharon-Peretz, Judith
Badarny, Samih
Ibrahim, Raphiq
Gershoni-Baruch, Ruth
Hassoun, Gamal
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Essential tremor (ET) and Parkinson's disease (PD) are probably the most common movement disorders. As ethnic differences have been reported in ET, we designed the present study to evaluate the prevalence of ET and that of Parkinson's disease (PD) in the Druze villages of northern Israel. Methods: A two-phase, door-to-door survey was undertaken. Residents aged ≥51 years who agreed to participate and answered “yes“  to tremor or PD-related screening questions and 3% of subjects who screened negative were evaluated. Diagnostic criteria for ET were similar to those used in Sicilian and Spanish studies. PD was diagnosed according to Gelb's criteria. Results: The target population consisted of 9,086, the study cohort of 3,980 residents. Tremor was observed in 36 subjects. In 27, the tremor fully met the criteria for ET. The prevalence of ET (age ≥65) was 1.49% (95% CI 0.91-2.07%). PD was diagnosed in 23 subjects. The prevalence of PD (age ≥65) was 1.13 (95% CI 0.62-1.64%). Leucine-rich repeat protein kinase 2 (G2019S mutation) was evaluated in subjects diagnosed with tremor PD and those screened for assessment of the validity of the questionnaire. None carried the mutation. Discussion: The prevalence of ET in the Druze population is low and similar to the prevalence of PD.
A hybrid line list for CH$_4$ and hot methane continuum
Creators: name: Yurchenko, Sergei N.
name: Amundsen, David S.
name: Tennyson, Jonathan
name: Waldmann, Ingo P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Molecular line lists are important for modelling absorption and emission processes in atmospheres of different astronomical objects, such as cool stars and exoplanets. In order to be applicable for high temperatures, line lists for molecules like methane must contain billions of transitions, which makes their direct (line-by-line) application in radiative transfer calculations impracticable. Here we suggest a new, hybrid line list format to mitigate this problem, based on the idea of temperature-dependent absorption continuum. The line list is partitioned into a large set of relatively weak lines and a small set of important, stronger lines. The weaker lines are then used either to construct a temperature-dependent (but pressure-independent) set of intensity cross sections or are blended into a greatly reduced set of super-lines. The strong lines are kept in the form of temperature independent Einstein A coefficients. A line list for methane is constructed as a combination of 17 million strong absorption lines relative to the reference absorption spectra and a background methane continuum in two temperature-dependent forms, of cross sections and super-lines. This approach eases the use of large high temperature line lists significantly as the computationally expensive calculation of pressure dependent profiles only need to be performed for a relatively small number of lines. Both the line list and cross sections were generated using a new 34 billion methane line list (34to10), which extends the 10to10 line list to higher temperatures (up to 2000 K). The new hybrid scheme can be applied to any large line lists containing billions of transitions. We recommend to use super-lines generated on a high resolution grid based on resolving power (R = 1,000,000) to model the molecular continuum as a more flexible alternative to the temperature dependent cross sections.
Supporting Information from Collective cell migration without proliferation: density determines cell velocity and wave velocity
Creators: name: Tlili, Sham
name: Gauquelin, Estelle
name: Li, Brigitte
name: Cardoso, Olivier
name: Ladoux, Benoît
name: Delanoë-Ayari, Hélène
name: Graner, François
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 20301 Acoustics and Acoustical Devices; Waves
subject: FOS: Physical sciences

description: 8 supplementary figures and 7 still images from supplementary movies
BESIII utilization of the Tianhe-2 supercomputer
Creators: name: Qiumei Ma
name: Jingkun Chen
name: Zheng, Wei
name: Tang, Jian
name: Zhang, Yao
name: Yuan, Ye
name: Jingyan Shi
name: Qiumei Ma
Publisher: name: Zenodo
Year: 2019

description: Supercomputer and other high performance computing resources can be useful supplements to the BESIII computing resources for simulation productions and data analysis. The supercomputer Tianhe-2 has ranked the No.1 on the Top500 certificate list for the sixth consecutive times during the year 2013 to 2015. This paper will describe the deployment singularity containers as well as the integration of local job submission system on the Tianhe-2 supercomputer in BESIII.
Additional file 3 of RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer
Creators: name: Li, Zengliang
name: Shi, Liang
name: Li, Xiangwei
name: Wang, Xiaopeng
name: Wang, Haixiao
name: Liu, Yeliu
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Table S3. Associations between RNF144A-AS1 expression and clinicopathological features of gastric cancer.
Examining the Motor Phenotype of Patients with Both Essential Tremor and Parkinson's Disease
Creators: Simões, Rita M.
Constantino, Anne
Gibadullina, Eliza
Houghton, David
Louis, Elan D.
Litvan, Irene
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: The subset of patients with essential tremor (ET) that develops Parkinson's disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p“Š=“Š0.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p“Š=“Š0.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p“Š=“Š0.001). ET→PD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.
Extreme solar storms based on solar magnetic field
Creators: name: Schmieder, Brigitte
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Many questions have to be answered before understanding the relationship between the emerging magnetic flux through the solar surface and the extreme geoeffective events. Which threshold determines the onset of the eruption? What is the upper limit in energy for a flare? Is the size of sunspot the only criteria to get extreme solar events? Based on observations of previous solar cycles, and theory, the main ingredients for getting X ray class flares and large Interplanetary Corona Mass Ejections e.g. the built up of the electric current in the corona, are presented such as the existence of magnetic free energy, magnetic helicity, twist and stress in active regions. The upper limit of solar flare energy in space research era and the possible chances to get super-flares and extreme solar events can be predicted using MHD simulation of coronal mass ejections
description: 21 pages,4 Figures, Varsiti Conference in Varna June 2016
Tables S1 - S3 from Competition between sympatric wolf taxa: an example involving African and Ethiopian wolves
Creators: name: Tariku Mekonnen Gutema
name: Anagaw Atickem
name: Afework Bekele
name: Sillero-Zubiri, Claudio
name: Kasso, Mohammed
name: Diress Tsegaye
name: Venkataraman, Vivek V.
name: Fashing, Peter J.
name: Zinner, Dietmar
name: Stenseth, Nils C.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Impact of the number of individuals of each wolf species present on the outcome of interactions.;Estimates, standard errors (SE) and P-values from a linear mixed effects model with Shannon diversity index (H) as the response variable, Grids as the random effect and habitat (buffer zone or core area) as the fixed effect.;Estimates of mole rat abundance in the buffer zone
High-Temperature Properties of the Z(3) Interface in (2+1)-D SU(3) Gauge Theory
Creators: name: West, S. T.
name: Wheater, J. F.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We study the high-temperature properties of the Z(3) interface which forms between the various ordered phases of pure SU(3) gauge theory above a critical temperature. On a (2+1)-D Euclidean lattice, we perform an accurate measurement of the interface tension, which shows good agreement with the prediction of perturbation theory. We also examine the behaviour of the Debye electric screening mass, and compare this with theoretical predictions.
description: 10 pages, 3 figures, uuencoded gzipped tar file
Searching for dark matter signatures in 20 years of GPS atomic clock data
Creators: name: Roberts, Benjamin
name: Derevianko, Andrei
name: Blewitt Geoffrey
name: Dailey, Conner
name: Panelli, Guglielmo
Publisher: name: Zenodo
Year: 2019

description: Despite the overwhelming cosmological evidence for the existence of dark matter, and the considerable effort of the scientific community over decades, there is no evidence for dark matter in terrestrial experiments. The GPS.DM observatory uses the existing GPS constellation as a 50,000 km-aperture sensor array, analysing the satellite and terrestrial atomic clock data for exotic physics signatures. In particular, the collaboration searches for evidence of transient variations of fundamental constants correlated with the Earth's galactic motion through the dark matter halo. The initial results of the search lead to an orders-of-magnitude improvement in constraints on certain models of dark matter [1]. I will discuss the initial results and future prospects, including the method used for processing the data, and the "GPS simulator" and dark-matter signal generator we built to test to methods [2]. [1] B. M. Roberts, G. Blewitt, C. Dailey, M. Murphy, M. Pospelov, A. Rollings, J. Sherman, W. Williams, and A. Derevianko, Nat. Commun. 8, 1195 (2017). [2] B. M. Roberts, G. Blewitt, C. Dailey, and A. Derevianko, Phys. Rev. D 97, 083009 (2018).
Energies from The influences of ammonia on aerosol formation in the ozonolysis of styrene: roles of Criegee intermediate reactions
Creators: name: Ma, Qiao
name: Xiaoxiao Lin
name: Chengqiang Yang
name: Long, Bo
name: Yanbo Gai
name: Weijun Zhang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30799 Theoretical and Computational Chemistry not elsewhere classified

description: Total energies calculated at the CBS-QB3 level.
Rate constants from The influences of ammonia on aerosol formation in the ozonolysis of styrene: roles of Criegee intermediate reactions
Creators: name: Ma, Qiao
name: Xiaoxiao Lin
name: Chengqiang Yang
name: Long, Bo
name: Yanbo Gai
name: Weijun Zhang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30799 Theoretical and Computational Chemistry not elsewhere classified

description: The rate constants for bimolecular reactions.
Metric adjusted skew information
Creators: name: Hansen, Frank
Publisher: name: arXiv
Year: 2006
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We extend the concept of Wigner-Yanase-Dyson skew information to something we call ``metric adjusted skew information'' (of a state with respect to a conserved observable). This ``skew information'' is intended to be a non-negative quantity bounded by the variance (of an observable in a state) that vanishes for observables commuting with the state. We show that the skew information is a convex function on the manifold of states. It also satisfies other requirements, proposed by Wigner and Yanase, for an effective measure-of-information content of a state relative to a conserved observable. We establish a connection between the geometrical formulation of quantum statistics as proposed by Chentsov and Morozova and measures of quantum information as introduced by Wigner and Yanase and extended in this article. We show that the set of normalized Morozova-Chentsov functions describing the possible quantum statistics is a Bauer simplex and determine its extreme points. We determine a particularly simple skew information, the ``lambda-skew information,'' parametrized by a lambda in (0,1], and show that the convex cone this family generates coincides with the set of all metric adjusted skew informations. Key words: Skew information, convexity, monotone metric, Morozova-Chentsov function, lambda-skew information.
description: Edited the abstract and the introduction
Controlling spoof plasmons in a metal grating using graphene surface plasmons
Creators: name: Dias, Eduardo J. C.
name: Peres, N. M. R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spoof plasmons mimic noble metal plasmons. The equivalent of the plasma frequency is an energy scale imposed by the geometry of the metal grating upon which they propagate. In this paper we show that the dispersion of spoof plasmons in the THz can be controlled placing a doped graphene sheet on the proximity of a metallic grating, adding more versatility to this type of system. We develop a semi-analytical model, based on a perfect-metal diffraction grating. This model allows to reproduce well FDTD calculations for the same problem but with much less computer time. We discuss the optical properties of the system covering a spectral range spanning the interval from the THz to the mid-IR. It is shown that the system can be used as both a perfect absorber and a sensing device. For illustrating the latter property we have chosen different alcohols as analytes. The frequency at which perfect absorption appears can be controlled by the geometric parameters of the grating and by the value of the Fermi energy in graphene. The theoretical results predicted throughout this work can be verified experimentally in the future.
description: 32 pages, with supplementary information included
Superclusters of galaxies from the 2dF redshift survey. I. The catalogue
Creators: name: Einasto, J.
name: Einasto, M.
name: Tago, E.
name: Saar, E.
name: Huetsi, G.
name: Jõeveer, M.
name: Liivamägi, L. J.
name: Suhhonenko, I.
name: Jaaniste, J.
name: Heinämäki, P.
name: Mueller, V.
name: Knebe, A.
name: Tucker, D.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We use the 2dF Galaxy Redshift Survey data to compile catalogues of superclusters for the Northern and Southern regions of the 2dFGRS, altogether 543 superclusters at redshifts 0.009 < z < 0.2. We analyse methods of compiling supercluster catalogues and use results of the Millennium Simulation to investigate possible selection effects and errors. We find that the most effective method is the density field method using smoothing with an Epanechnikov kernel of radius 8 Mpc/h. We derive positions of the highest luminosity density peaks and find the most luminous cluster in the vicinity of the peak, this cluster is considered as the main cluster and its brightest galaxy the main galaxy of the supercluster. In catalogues we give equatorial coordinates and distances of superclusters as determined by positions of their main clusters. We also calculate the expected total luminosities of the superclusters.
description: 16 pages, 11 figures, submitted for Astronomy and Astrophysics. High-resolution pdf file and supplementary data can be found at http://www.aai.ee/~maret/2dfscl.html
SPG11 Presenting with Tremor
Creators: Schneider, Susanne A.
Mummery, Catherine J.
Mehrabian, Mohadeseh
Houlden, Henry
Bain, Peter G.
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of neurological diseases, which typically present with progressive lower extremity weakness and spasticity causing progressive walking difficulties. Complicating neurological or extraneurological features may be present. Case Report: We describe a 19-year-old male who was referred because of an action tremor of the hands; he later developed walking difficulties. Callosal atrophy was present on his cerebral magnetic resonance imaging scan, prompting genetic testing for SPG11, which revealed homozygous mutations. Discussion: The clinical features, differential diagnosis and management of SPG11, the most common form of autosomal recessive complicated HSP with a thin corpus callosum are discussed.
Positional Torticollis While Lying on Side
Creators: Belenky, Vadim
Pesonina, Svetlana
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Spasmodic torticollis refers to involuntary dystonic movements of the head that may be associated with certain body and neck positions. The pathophysiology of dystonia is not fully known. Case Report: We report a case of torticollis that was unusual in the sense that it occurred only when the patient was lying on one side. Discussion: The cause of the cervical dystonia in this patient was unclear and the positional nature of the movements was unusual.
Production processing and workflow management software evaluation in the DUNE collaboration
Creators: name: Herner, Kenneth Richard
Publisher: name: Zenodo
Year: 2019

description: The Deep Underground Neutrino Experiment (DUNE) will be the world's foremost neutrino detector when it begins taking data in the mid-2020s. Two prototype detectors, collectively known as ProtoDUNE, have begun taking data at CERN and have accumulated over 3 PB of raw and reconstructed data since September 2018. Particle interaction within liquid argon time projection chambers are challenging to reconstruct, and the collaboration has set up a dedicated Production Processing group to perform centralized reconstruction of the large ProtoDUNE datasets as well as to generate large-scale Monte Carlo simulation. Part of the production infrastructure includes workflow management software and monitoring tools that are necessary to efficiently submit and monitor the large and diverse set of jobs needed to meet the experiment's goals. We will give a brief overview of DUNE and ProtoDUNE, describe the various types of jobs within the Production Processing group's purview, and discuss the software and workflow management strategies are currently in place to meet existing demand. We will conclude with a description of our requirements in a workflow management software solution and our planned evaluation process.
Geometries from The influences of ammonia on aerosol formation in the ozonolysis of styrene: roles of Criegee intermediate reactions
Creators: name: Ma, Qiao
name: Xiaoxiao Lin
name: Chengqiang Yang
name: Long, Bo
name: Yanbo Gai
name: Weijun Zhang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30799 Theoretical and Computational Chemistry not elsewhere classified

description: Geometries optimized at the B3LYP/6-311G++(2d,2p).
Dual Treatment of Hemichorea–Hemiballismus Syndrome with Tetrabenazine and Chemodenervation
Creators: Umeh, Chizoba C.
Nichols, Paige
Rosenthal, Liana S.
Mari, Zoltan
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Hemichorea–hemiballismus involves unilateral involuntary flailing movements and random jerking movements involving proximal or distal muscles. We describe a case of hemichorea–hemiballismus with dystonia after stroke. Treatment with tetrabenazine and chemodenervation produced beneficial responses. Effective treatment of both hemichorea–hemiballismus and dystonia due to stroke has not been reported.
General Relativistic effects in the structure of massive white dwarfs
Creators: name: Carvalho, G. A.
name: Marinho, R. M.
name: Malheiro, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this work we investigate the structure of white dwarfs using the Tolman-Oppenheimer-Volkoff equations and compare our results with those obtained from Newtonian equations of gravitation in order to put in evidence the importance of General Relativity (GR) for the structure of such stars. We consider in this work for the matter inside white dwarfs two equations of state, frequently found in the literature, namely, the Chandrasekhar and Salpeter equations of state. We find that using Newtonian equilibrium equations, the radii of massive white dwarfs ($M>1.3M_{\odot}$) are overestimated in comparison with GR outcomes. For a mass of $1.415M_{\odot}$ the white dwarf radius predicted by GR is about 33\% smaller than the Newtonian one. Hence, in this case, for the surface gravity the difference between the general relativistic and Newtonian outcomes is about 65\%. We depict the general relativistic mass-radius diagrams as $M/M_{\odot}=R/(a+bR+cR^2+dR^3+kR^4)$, where $a$, $b$, $c$ and $d$ are parameters obtained from a fitting procedure of the numerical results and $k=(2.08\times 10^{-6}R_{\odot})^{-1}$, being $R_{\odot}$ the radius of the Sun in km. Lastly, we point out that GR plays an important role to determine any physical quantity that depends, simultaneously, on the mass and radius of massive white dwarfs.
description: To be published in General Relativity and Gravitation
Cerebellar Pathology of a Dual Clinical Diagnosis: Patients with Essential Tremor and Dystonia
Creators: Ma, Karen
Babij, Rachel A.
Cortes, Etty Paola
Louis, Elan D.
Vonsattel, Jean Paul
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Clinical studies have implicated the cerebellum in the pathogenesis of essential tremor (ET), and recent postmortem studies have identified structural changes in the ET cerebellum. While the basal ganglia have traditionally been implicated in dystonia, cerebellar involvement has been suggested as well, and a recent study showed Purkinje cell (PC) loss. We conducted a detailed postmortem examination of the brain in four individuals with clinical diagnoses of ET and dystonia, and hypothesized that pathological changes in the cerebellum would be greater in these four ET cases than in published ET cases without dystonia. Methods: After a complete neuropathological assessment, a standard parasagittal neocerebellar tissue block was harvested in each brain. One 7-µm thick section was stained with luxol fast blue/hematoxylin and eosin, and one section with the Bielschowsky method. We quantified PCs, torpedoes, heterotopic PCs, PC dendritic swellings, and basket cell changes. Results: Two ET+dystonia cases had more microscopic changes in the cerebellum than published ET cases; the other two cases had similar changes to published ET cases. Discussion: This is the first report that uses human autopsy tissue to study patients with both ET and dystonia. The findings were heterogeneous. Additional studies, with larger samples, are needed.
Performance of Belle II tracking on collision data
Creators: name: Glazov, Alexander
name: Paoloni, Eugenio
name: Kuhr, Thomas
Publisher: name: Zenodo
Year: 2019

description: The tracking system of Belle II consists of a silicon vertex detector (VXD) and a cylindrical drift chamber (CDC), both operating in a magnetic field created by the main solenoid of 1.5 T and final focusing magnets. The Belle II VXD is a combined tracking system composed by two layers of pixel detectors married with four layers of double sided silicon strip sensors (SVD). The drift chamber consists of 56 layers of sense wires, arranged in interleaved axial and stereo superlayers, to assist track finding and provide full 3D tracking. The tracking algorithms employed at Belle II are based on a standalone reconstruction in SVD and CDC as well as on a combination of the two approaches. The tracking reconstruction is tested on the collision data collected in 2018 and 2019, the results are reported in this talk.
Carfentanil - Molecule of the Month December 2018 [Archived version] Item
Creators: name: Cotton, Simon
Publisher: name: figshare
Year: 2018
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for December 2018 about carfentanil. It is a pdf archive version of the HTML webpage.
Study of the Q.Q Interaction- Single Particle Behavior to Elliott's Rotations
Creators: name: Kingan, Arun
name: Yu, Xiaofei
name: Zamick, Larry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We perform shell model calculations using a quadrupole-quadrupole interaction (Q.Q).We show results in single j shell spaces and the full S-D shell . We show that one gets useful results with Q.Q in both spaces.. We emphasize the importance of the choice of single particle energies in order to obtain the results of Elliott using a Q.Q interaction without the momentum terms. We show a J(J+1) spectrum for a ground state band but with B(E2)'s different from the rotational model. We also show excited J(J-1), J((J-1) and J(J+3) spectra.We find spectra starting with J=0 which have both even J and odd J members.
Additional file 4 of RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer
Creators: name: Li, Zengliang
name: Shi, Liang
name: Li, Xiangwei
name: Wang, Xiaopeng
name: Wang, Haixiao
name: Liu, Yeliu
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S1. RNF144A-AS1 preserved non-coding feature. A Analysis of RNF144A-AS1 expression in tumor tissues with or without distant metastasis (n = 8 for each group). B The coding potential of RNF144A-AS1 was low from CAPT. C Prediction of coding potential to RNF144A-AS1 using ORF finder. *P < 0.05 by Student’s t-test unless otherwise specified.
Hamiltonians for the Quantum Hall Effect on Spaces with Non-Constant Metrics
Creators: name: Bracken, P
Publisher: name: arXiv
Year: 2006
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The problem of studying the quantum Hall effect on manifolds with nonconstant metric is addressed. The Hamiltonian on a space with hyperbolic metric is determined, and the spectrum and eigenfunctions are calculated in closed form. The hyperbolic disk is also considered and some other applications of this approach are discussed as well.
description: 16 pages
Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database
Creators: name: Doytchinova, Irini
name: Atanasova, Mariyana
name: Valkova, Iva
name: Stavrakov, Georgi
name: Philipova, Irena
name: Zhivkova, Zvetanka
name: Zheleva-Dimitrova, Dimitrina
name: Konstantinov, Spiro
name: Dimitrov, Ivan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The inhibition of the enzyme acetylcholinesterase (AChE) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. In the present study, we searched for novel AChE inhibitors by docking-based virtual screening of the standard lead-like set of ZINC database containing more than 6 million small molecules using GOLD software. The top 10 best-scored hits were tested in vitro for AChE affinity, neurotoxicity, GIT and BBB permeability. The main pharmacokinetic parameters like volume of distribution, free fraction in plasma, total clearance, and half-life were predicted by previously derived models. Nine of the compounds bind to the enzyme with affinities from 0.517 to 0.735 µM, eight of them are non-toxic. All hits permeate GIT and BBB and bind extensively to plasma proteins. Most of them are low-clearance compounds. In total, seven of the 10 hits are promising for further lead optimisation. These are structures with ZINC IDs: 00220177, 44455618, 66142300, 71804814, 72065926, 96007907, and 97159977.
WLCG Web Proxy Auto Discovery for Dynamically Created Web Proxies
Creators: name: Gutsche, Oliver
Publisher: name: Zenodo
Year: 2019

description: The WLCG Web Proxy Auto Discovery (WPAD) service provides a convenient mechanism for jobs running anywhere on the WLCG to dynamically discover web proxy cache servers that are nearby. The web proxy caches are general purpose for a number of different http applications, but different applications have different usage characteristics and not all proxy caches are engineered to work with the heaviest loads. For this reason, the initial sources of information for WLCG WPAD were the static configurations that ATLAS and CMS maintain for the Conditions data that they read through the Frontier Distributed Database system, which is the most demanding popular WLCG application for web proxy caches. That works well for use at traditional statically defined WLCG sites, but now that usage of commercial clouds is increasing, there is also a need for web proxy caches to dynamically register themselves as they are created. A package called Shoal had already been created to manage dynamically created web proxy caches. This paper describes the integration of the Shoal package into the WLCG WPAD system, such that both staticly and dynamically created web proxy caches can be located from a single source. It also describes other improvements to the WLCG WPAD system since the last CHEP publication.
Turbulent diffusion in protoplanetary discs: the effect of an imposed magnetic field
Creators: name: Johansen, Anders
name: Klahr, Hubert
name: Mee, Antony J.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the effect of an imposed vertical magnetic field on the turbulent mass diffusion properties of magnetorotational turbulence in protoplanetary discs. It is well-known that the effective viscosity generated by the turbulence depends strongly on the magnitude of such an external field. In this letter we show that the turbulent diffusion of the flow also grows, but that the diffusion coefficient does not rise with increasing vertical field as fast as the viscosity does. The vertical Schmidt number, i.e. the ratio between viscosity and vertical diffusion, can be close to 20 for high field magnitudes, whereas the radial Schmidt number is increased from below unity to around 3.5. Our results may have consequences for the interpretation of observations of dust in protoplanetary discs and for chemical evolution modelling of these discs.
description: Accepted for publication in MNRAS
Machine learning search for variable stars
Creators: name: Pashchenko, Ilya N.
name: Sokolovsky, Kirill V.
name: Gavras, Panagiotis
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Photometric variability detection is often considered as a hypothesis testing problem: an object is variable if the null-hypothesis that its brightness is constant can be ruled out given the measurements and their uncertainties. Uncorrected systematic errors limit the practical applicability of this approach to high-amplitude variability and well-behaving data sets. Searching for a new variability detection technique that would be applicable to a wide range of variability types while being robust to outliers and underestimated measurement uncertainties, we propose to consider variability detection as a classification problem that can be approached with machine learning. We compare several classification algorithms: Logistic Regression (LR), Support Vector Machines (SVM), k-Nearest Neighbors (kNN) Neural Nets (NN), Random Forests (RF) and Stochastic Gradient Boosting classifier (SGB) applied to 18 features (variability indices) quantifying scatter and/or correlation between points in a light curve. We use a subset of OGLE-II Large Magellanic Cloud (LMC) photometry (30265 light curves) that was searched for variability using traditional methods (168 known variable objects identified) as the training set and then apply the NN to a new test set of 31798 OGLE-II LMC light curves. Among 205 candidates selected in the test set, 178 are real variables, 13 low-amplitude variables are new discoveries. We find that the considered machine learning classifiers are more efficient (they find more variables and less false candidates) compared to traditional techniques that consider individual variability indices or their linear combination. The NN, SGB, SVM and RF show a higher efficiency compared to LR and kNN.
description: 19 pages, 13 figures, 5 tables; accepted to MNRAS
Optical Absorption by Indirect Excitons in a Transition Metal Dichalcogenide Double Layer
Creators: name: Brunetti, Matthew N.
name: Berman, Oleg L.
name: Kezerashvili, Roman Ya.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We calculate the binding energy, transition energies, oscillator strength, and absorption coefficient of indirect excitons in transition metal dichalcogenide (TMDC) double layers separated by an integer number of hexagonal boron nitride (h-BN) monolayers. The absorption factor, a dimensionless quantity which gives the fraction of incoming photons absorbed by the indirect excitons in the double layer, is evaluated. The aforementioned optical quantities are obtained for transitions from the ground state to the first two excited states. All quantities are studied as a function of the interlayer separation, which may be experimentally controlled by varying the number of h-BN monolayers between the TMDC layers. Calculations are performed by using the exciton wave function and eigenenergies obtained for the Keldysh potential. For each material, we choose a combination of the exciton reduced mass and the dielectric screening length from the existing literature which give the largest and the smallest indirect exciton binding energy. These combinations of material parameters provide upper and lower bounds on all quantities presented. Our findings can be examined experimentally via two-photon spectroscopy.
description: 13 pages, 3 figures
The CMS electromagnetic calorimeter workflow
Creators: name: CMS Collaboration
Publisher: name: Zenodo
Year: 2019

description: The CMS experiment at the LHC features the largest crystal electromagnetic calorimeter (ECAL) ever built. It consists of about 75000 scintillating lead tungstate crystals. The ECAL crystal energy response is fundamental for both triggering purposes and offline analysis. Due to the challenging LHC radiation environment, the response of both crystals and photodetectors to particles evolves with time. Therefore continuous monitoring and correction of the ageing effects plays a key role in ensuring stability of trigger efficiency and rate, as well as optimal offline physics performance. Fast, reliable and efficient workflows are set up to have the first set of corrections computed within 48 hours of data-taking, making use of dedicated data streams and processing. Such corrections, stored in relational databases (Oracle), are then accessed during the prompt offline reconstruction of CMS data. Twice a week, the calibrations used at the trigger level (hardware and software) are also updated in the database and accessed during the data-taking. Dedicated workflows for the prompt validation of the conditions are also available, together with a monitoring of the data quality. In this presentation, the design of the CMS ECAL data handling, processing, and validation is reviewed, and results from the main workflows are discussed.
Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives
Creators: name: Mosaad S. Mohamed
name: Mansour, Yara E.
name: Amin, Hatem K.
name: El-Araby, Moustafa E.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors of the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5-lipoxygensase (5-LOX). Testing these compounds in a rat paw oedema model revealed potency higher than ibuprofen. The most active compounds 7a, 7b, 8b, and 8c were screened against COX-1/2 and 5-LOX enzymes. Compound 7a was the most powerful inhibitor of 5-LOX with IC50 = 0.15 µM, while its p-chloro analogue 7b was more active against COX-2 (IC50 = 7.5 µM). The less desirable target COX-1 was inhibited more potently by 8c with IC50 = 7.7 µM. Surflex docking programme predicted that the more stable anti- conformer of compound (7a) formed a favourable complex with the active site of 5-LOX but not COX-1. This is in contrast to the binding mode of 8c, which resembles the syn-conformer of series 7 and binds favourably to COX-1.
Coherent State Quantization of Constraint Systems
Creators: name: Klauder, John R.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A careful reexamination of the quantization of systems with first- and second-class constraints from the point of view of coherent-state phase-space path integration reveals several significant distinctions from more conventional treatments. Most significantly, we emphasize the importance of using path-integral measures for Lagrange multipliers which ensure that the quantum system satisfies the quantum constraint conditions. Our procedures involve no delta-functionals of the classical constraints, no need for gauge fixing of first-class constraints, no need to eliminate second-class constraints, no potentially ambiguous determinants, and have the virtue of resolving differences between canonical and path-integral approaches. Several examples are considered in detail.
description: Latex, 38 pages, no figures
Multilayers black phosphorus: from tight-binding to continuum description
Creators: name: de Souza, D. J. P.
name: de Castro, L. V.
name: da Costa, D. R.
name: Pereira, J. Milton
name: Low, Tony
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the electronic properties of $N$-layer black phosphorus by means of an analytical method based on a recently proposed tight-binding Hamiltonian involving $14$ hopping parameters. The method provides simple and accurate general expressions for the Hamiltonian of $N$-layer phosphorene, which are suitable for the study of electronic transport and optical properties of such systems, and the results show the features that emerge as the number of layers increases. In addition, we show that the $N$-layer problem can be translated into $N$ effective monolayer problems in the long wavelength approximation and, within this analytical picture, we obtain expressions for the energy gap and the effective masses for electrons and holes along the $N$-layer black phosphorus plane directions as function of the number of layers, as well as for the Landau levels as function of perpendicular magnetic field.
description: 12 pages, 7 figures
Geometric Properties of Quantum Phases
Creators: name: Bracken, P
Publisher: name: arXiv
Year: 2006
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The Aharonov-Anandan phase is introduced from a physical point of view. Without reference to any dynamical equation, this phase is formulated by defining an appropriate connection on a specific fibre bundle. The holonomy element gives the phase. By introducing another connection, the Pancharatnam phase formula is derived following a different procedure.
description: 9 pages
Quantifying high-dimensional entanglement with Einstein-Podolsky-Rosen correlations
Creators: name: Schneeloch, James
name: Howland, Gregory A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantifying entanglement in a quantum system generally requires a complete quantum tomography followed by the NP-hard computation of an entanglement monotone --- requirements that rapidly become intractable at higher dimensions. Observing entanglement in large quantum systems has consequently been relegated to witnesses that only verify its existence. In this article, we show that the violation of recent entropic witnesses of the Einstein-Podolsky-Rosen paradox also provides tight lower bounds to multiple entanglement measures, such as the entanglement of formation and the distillable entanglement, among others. Our approach only requires the measurement of correlations between two pairs of complementary observables---not a tomography---so it scales efficiently at high dimension. Despite this, our technique captures almost all the entanglement in common high-dimensional quantum systems, such as spatially or temporally entangled photons from parametric down-conversion.
description: 7 pages, 2 figures, including Supplemental Material
The Lorentzian distance formula in noncommutative geometry
Creators: name: Franco, Nicolas
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: 58B34, 53C50, 54E35

description: For almost twenty years, a search for a Lorentzian version of the well-known Connes' distance formula has been undertaken. Several authors have contributed to this search, providing important milestones, and the time has now come to put those elements together in order to get a valid and functional formula. This paper presents a historical review of the construction and the proof of a Lorentzian distance formula suitable for noncommutative geometry.
description: 16 pages, final form, few references added
Movements Mimicking Myoclonus Associated with Spinal Cord Pathology: Is This a "Pure Motor Restless Legs Syndrome"?
Creators: Ondo, William G.
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: The neuroanatomic substrate of restless legs syndrome (RLS) is poorly understood, and the diagnosis is clinically made based upon subjective sensory symptoms, although a motor component is usually present. Case Report: We report two cases of elderly patients with spinal pathology who were referred by neurologists for myoclonus. Both had semi-rhythmic leg movements that partially improved while standing, but denied any urge to move. These movements improved dramatically with pramipexole, a dopamine agonist used for RLS. Discussion: We propose that this "myoclonus" is actually the isolated stereotypic motor component of RLS.
3--Dimensional Lattice Studies of the Electroweak Phase Transition at M_{Higgs} approx 70 GeV
Creators: name: Guertler, M.
name: Ilgenfritz, E. -M.
name: Kripfganz, J.
name: Perlt, H.
name: Schiller, A.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We study the electroweak phase transition by lattice simulations of an effective 3--dimensional theory, for a Higgs mass of about 70 GeV. Exploiting, among others, a variant of the equal weight criterion of phase equilibrium, we obtain transition temperature, latent heat and surface tension, and compare with M_H approx 35 GeV. In the broken phase masses and Higgs condensates are compared to perturbation theory. For the symmetric phase, bound state masses and the static force are determined.
description: latex, 34 pages, 19 figures, 1 figure empty, the full ps file can be obtained from: http://www.physik.uni-leipzig.de/TET/ape/EWPT.html
Telling Tales: A Survey of Narratological Approaches to Music
Creators: Millard, Russell
Publisher: name: Columbia University
Year: 2018
Subjects: Musicology
Narrative inquiry (Research method)
Musical analysis
Music--Philosophy and aesthetics
Interdisciplinary research

description: Of the various hermeneutic approaches to the study of music developed in the last half century or so, narratological analysis has gone further than many in navigating a path that draws on both cultural and structural contexts. This overview of the development of narrative theory in music charts the course of three “waves” of narratological engagement with music: 1) the scholars of the 1980s, such as Anthony Newcomb, Susan McClary, and Patrick McCreless, whose work focused on narrative in instrumental tonal music; 2) a period of critical reappraisal of musical narrative in the 1990s by writers such as Jean-Jacques Nattiez and Carolyn Abbate; 3) the opening up of narrative theory to broader musical repertories—e.g. film and popular music—with scholars such as Nicholas Reyland. Important strands of narrative thinking are highlighted, demonstrating the significance of balancing structural and “humanistic” approaches to the study of music through narrative, encouraging close theoretical links between cultural and analytical readings.