cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer
Creators: name: Lin, Ling-Yun
name: Yang, Li
name: Zeng, Qiang
name: Wang, Lin
name: Chen, Mao-Li
name: Zhao, Ze-Hang
name: Ye, Guo-Dong
name: Luo, Qi-Cong
name: Lv, Pei-Yu
name: Guo, Qi-Wei
name: Li, Bo-An
name: Cai, Jian-Chun
name: Cai, Wang-Yu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Figure S2. qPCR analysis of the relative lncUEGC1 and lncUEGC2 levels in exosomes and exosomes-depleted plasma from stage I and II GC patients (n = 5). Differences with P < 0.05 were considered statistically significant. (PDF 210 kb)
Additional file 6: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer
Creators: name: Lin, Ling-Yun
name: Yang, Li
name: Zeng, Qiang
name: Wang, Lin
name: Chen, Mao-Li
name: Zhao, Ze-Hang
name: Ye, Guo-Dong
name: Luo, Qi-Cong
name: Lv, Pei-Yu
name: Guo, Qi-Wei
name: Li, Bo-An
name: Cai, Jian-Chun
name: Cai, Wang-Yu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S4. Performance of CEA, IncUEGC1 and IncUEGC2 levels in the classification of GC and Healthy subsets, Stage I and Healthy subsets, Stage I and CAG subsets. (PDF 154Â kb)
Additional file 3: of Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy
Creators: name: Chen, Branson
name: Lee, Jong
name: Kang, Hyeonjeong
name: Minden, Mark
name: Zhang, Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Table S1. Percentages of dead AML3 and KG1a cells after chemotherapy and DNT co-culture. This table shows the original percentages of dead cells in the assays illustrated in Fig. 2A and B, which were performed in triplicate. Flow cytometry analysis, with Annexin-V as a viability marker, was employed to determine cell viability after the treatments. (DOCX 13Â kb)
Additional file 7: of Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer
Creators: name: Lin, Ling-Yun
name: Yang, Li
name: Zeng, Qiang
name: Wang, Lin
name: Chen, Mao-Li
name: Zhao, Ze-Hang
name: Ye, Guo-Dong
name: Luo, Qi-Cong
name: Lv, Pei-Yu
name: Guo, Qi-Wei
name: Li, Bo-An
name: Cai, Jian-Chun
name: Cai, Wang-Yu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Methods. (PDF 289Â kb)
Additional file 5: of Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy
Creators: name: Chen, Branson
name: Lee, Jong
name: Kang, Hyeonjeong
name: Minden, Mark
name: Zhang, Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S2. Clinical characteristics of 13 AML patients whose AML blasts were used for in vitro assays. Abbreviations: WBC – White blood cell; BM – Bone marrow; FAB – The French-American-British classification of AML; MRC – Medical Research Council cytogenetic classification; MDS – Myelodysplastic syndrome; MK – Monosomal Karyotype; NPM1 – Nucleophosmin 1; FLT3-ITD – Fms related tyrosine kinase 3 - internal tandem duplication; FLT3-TKD – Fms related tyrosine kinase 3 - tyrosine kinase domain; BCR-ABL – Break point cluster region - Abelson murine leukemia viral oncogene homolog 1; RAR – Retinoic acid receptor. (DOCX 17 kb)
Additional file 6: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)
Creators: name: Wang, Ying
name: Guo, Shirong
name: Wang, Lei
name: Wang, Liwei
name: He, Xueying
name: Shu, Sheng
name: Sun, Jin
name: Lu, Na
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: Table S5. The interaction between high-temperature and Spd in miRNAs responsive to both high-temperature and Spd. (DOCX 15Â kb)
Additional file 7: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)
Creators: name: Wang, Ying
name: Guo, Shirong
name: Wang, Lei
name: Wang, Liwei
name: He, Xueying
name: Shu, Sheng
name: Sun, Jin
name: Lu, Na
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Table S6. Annotation of potential genes targeted by miRNAs responding to both high-temperature and exogenous spermidine. (DOCX 17Â kb)
Additional file 9: of Identification of microRNAs associated with the exogenous spermidine-mediated improvement of high-temperature tolerance in cucumber seedlings (Cucumis sativus L.)
Creators: name: Wang, Ying
name: Guo, Shirong
name: Wang, Lei
name: Wang, Liwei
name: He, Xueying
name: Shu, Sheng
name: Sun, Jin
name: Lu, Na
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Table S8. Primers of miRNAs and target genes used for qRT-PCR. (DOCX 16Â kb)
Additional file 1: of Developing a core outcome set for people living with dementia at home in their neighbourhoods and communities: study protocol for use in the evaluation of non-pharmacological community-based health and social care interventions
Creators: name: Harding, Andrew
name: Morbey, Hazel
name: Ahmed, Faraz
name: Opdebeeck, Carol
name: Wang, Ying-Ying
name: Williamson, Paula
name: Swarbrick, Caroline
name: Leroi, Iracema
name: Challis, David
name: Davies, Linda
name: Reeves, David
name: Holland, Fiona
name: Hann, Mark
name: HellstrĂśm, Ingrid
name: HydĂŠn, Lars-Christer
name: Burns, Alistair
name: Keady, John
name: Reilly, Siobhan
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Recommended items to address in a clinical trial protocol and related documents*. (DOC 119Â kb)
Cyanobiphenyl-based liquid crystal dimers and the twist-bend nematic phase
Creators: name: Paterson, Daniel A
name: Abberley, Jordan P
name: Harrison, William TA
name: John MD Storey
name: Imrie, Corrie T
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The synthesis and characterisation of several members of the 1,ω-bis(4-cyanobiphenyl-4′-yl) alkane (CBnCB) and the 1-(4-cyanobiphenyl-4′-yloxy)-ω-(4-cyanobiphenyl-4′-yl) alkane (CBnOCB) homologous series are reported. The new odd members described CB5CB, CB13CB, CB4OCB, CB8OCB and CB10OCB all exhibit twist-bend nematic and nematic phases. The members of these series already reported in literature, CB7CB, CB9CB, CB11CB and CB6OCB, were also prepared in order to allow for a direct comparison of their transitional properties. The properties of these dimers are also compared to those of the corresponding members of the 1,ω-bis(4-cyanobiphenyl-4,-yloxy) alkanes (CBOnOCB). For any given total spacer length, for odd members of these series, the nematic–isotropic transition temperatures and associated entropy changes are greatest for the CBOnOCB dimer and lowest for the CBnCB dimer. These trends are understood in terms of molecular shape. For short spacer lengths, the twist-bend nematic–nematic transition temperature (TNTBN) is higher for the CBnOCB series than for the CBnCB series but this is reversed as the spacer length increases. Of the CBOnOCB dimers, a virtual value of TNTBN was estimated for CBO3OCB and TNTBN was measured for CBO5OCB. These values are considerably lower than those observed for the corresponding members of the CBnCB or CBnOCB series. The dependence of TNTBN on molecular structure is discussed not only in terms of the molecular curvature but also in the ability of the molecules to pack efficiently. As the temperature range of the preceding nematic phase increases, so the twist-bend nematic–nematic transition entropy change decreases and the transition approaches second order for the longer spacers. For comparative purposes, the transitional behaviour of the even-membered dimers CB6CB, CB5OCB and CBO4OCB is reported and differences accounted for in terms of molecular shape.
An Overview of Autosomal Dominant Tumour Syndromes with Prominent Features in the Oral and Maxillofacial Region
Creators: name: RA, Kennedy
name: Thavaraj S
name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2017
Subjects: subject: 111202 Cancer Diagnosis
subject: FOS: Clinical medicine
subject: 111203 Cancer Genetics
subject: 111201 Cancer Cell Biology
subject: 110304 Dermatology
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110505 Oral Medicine and Pathology
subject: Pathogenesis

description: Several autosomal dominant inherited tumor syndromes demonstrate prominent features in the oral and maxillofacial region. Although multiple organ systems are frequently involved, the target organs more commonly affected are the skin (nevoid basal cell carcinoma syndrome, Brooke–Spiegler syndrome, Birt–Hogg–Dube syndrome and Muir–Torre syndrome), gastrointestinal tract (Peutz–Jegher syndrome and Gardner syndrome) or endocrine system (multiple endocrine neoplasia type 2b and hyperparathyroidism-jaw tumour syndrome). In some syndromes, the disease is multisystem with skin index lesions presenting in the head and neck (Cowden syndrome and tuberous sclerosis complex). The pertinent features of these syndromes are reviewed with a systems-based approach, emphasizing their clinical impact and diagnosis.
Additional file 1: of PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions
Creators: name: Zou, Xu-Dong
name: An, Ke
name: Wu, Yun-Dong
name: Ye, Zhi-Qiang
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Medicine
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Figure S1. Workflow of this study. Figure S2. Overview of the ALL-PPI network. Figure S3. Degree distributions of nodes in two networks. Figure S4. Percentage of WD40 proteins in each k-core subnetwork during the decomposition of ALL-PPI network. Figure S5. Distributions of average PCCs of WD40 hubs, non-WD40 hubs, and randomized data in ALL-PPI network. Figure S6. The number of reference complexes matched with predicted complexes obtained by different methods. Figure S7. The number of reference complexes matched with predicted complexes obtained from ALL-PPI network under different ω. Figure S8. Number of complexes in reference set matched with predicted complexes obtained from different PPI networks. Figure S9. k-core decomposition and localization of hubs in PPI network. Table S2. Counts of hubs in WD40 and non-WD40 proteins in ALL-PPI network. Table S3. Counts of hubs in WD40 and non-WD40 under different definitions. Table S4. Comparisons of centralities between WD40 and non-WD40 in two networks. Table S5. WD40 proteins in different layers obtained by k-core decomposition of ALL-PPI network. Table S6. Orthologs of MED16, GBLP, and CORO1C in model organisms. Table S7. Medians of average PCCs of WD40 hubs and non-WD40 hubs in two networks. Table S9. Statistics of complex predictions  based on HC-PPI under different parameter settings. Table S11. Number of predicted complexes under different methods, and the matched numbers of reference complexes under different ω. Table S12. Comparisons of MMR for different prediction methods with ω> = 0.2. Table S13. Statistics of complex prediction obtained from ALL-PPI under different parameter settings. Table S14. Medians of co-expression scores for different complex sets under different expression dataset. (PDF 1014 kb)
Additional file 5: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep
Creators: name: Yu, Hui
name: Waddell, Jolena
name: Kuang, Shihuan
name: Tellam, Ross
name: Cockett, Noelle
name: Bidwell, Christopher
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Transcript abundance of RPLP0 in 7 muscles. Least square means and standard errors for log transcript abundance are shown for each muscle and genotype, callipyge (+/C) and normal (+/+). The hypertrophied muscles are LD, SM, ST, and TB and the non-hypertrophied muscles are SS, IS and HT. RPLP0 was used as a control to confirm equivalent RNA input into cDNA synthesis and qPCR assays. No significant differences were detected between the two genotypes in all the muscles analyzed. (PDF 21Â kb)
Additional file 6: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep
Creators: name: Yu, Hui
name: Waddell, Jolena
name: Kuang, Shihuan
name: Tellam, Ross
name: Cockett, Noelle
name: Bidwell, Christopher
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Cellular localization of DNTTIP1. C2C12 cells were transfected with pDNTTIP1-pcDNA3.2 /V5 construct and stained with anti-DNTTIP1 antibody (red), anti-V5 epitope tag antibody (green) and DAPI (nuclei, blue). The merged cells (orange) showed the detection of the same cells by anti-DNTTIP1 and anti-V5 antibodies. DNTTIP1 localized exclusively in nucleus in C2C12 cells. (PDF 43Â kb)
Additional file 1: of OCEAN-C: mapping hubs of open chromatin interactions across the genome reveals gene regulatory networks
Creators: name: Li, Tingting
name: Jia, Lumeng
name: Cao, Yong
name: Chen, Qing
name: Li, Cheng
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology
subject: Computational Biology

description: Figures S1â S11. (PDF 5443Â kb)
Cytochromes P450 activity and functionality: biomarker of drug response and valuable tool for Precision Medicine
Creators: name: Samer, Caroline Flora
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/617
Cytochromes P450
Precision Medicine
Personalized Medicine
Oxycodone
Phenotyping
Genotyping
PBPK modeling

description: The variations in the activity and functionality of drug metabolizing enzymes and in particular cytochromes P450 (CYP) are major determinants of drug therapeutic outcomes as they impact on drug pharmacokinetics. This thesis aims to describe the crucial role of integrative methods assessing the impact of genetic and environmental factors on CYP activity to support safe and effective drug therapies and more broadly precision medicine. After an outline on precision medicine and its major component pharmacogenomics, the characteristics of CYPs and importance in the field are described. In vitro, in vivo, and in silico methods allowing studying drug metabolism and CYP activity are then presented, and in particular the Geneva cocktail for CYP phenotyping developed and validated in our laboratory. Applications for clinical research and clinical pharmacology are then exemplified by the centenary opioid oxycodone whose pharmacokinetics and pharmacodynamics were reappraised using in vitro, in vivo and in silico technologies. Our findings led to clinical recommendations fully applicable to precision medicine. Finally, we review the current evidence on the clinical impact of CYP activity variations from genetic and environmental origins on drug response, and in particular clinical applications of CYP testing in pain medicine and other relevant medical specialties.
Additional file 7: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep
Creators: name: Yu, Hui
name: Waddell, Jolena
name: Kuang, Shihuan
name: Tellam, Ross
name: Cockett, Noelle
name: Bidwell, Christopher
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Cellular localization of PARK7. C2C12 cells were transfected with pPARK7-pcDNA3.2 /V5 construct and stained with anti-PARK7 (green), anti-V5 epitope tag (red) and DAPI (nuclei, blue). The merged cells (orange) showed the detection of the same cells by anti-PARK7 and anti-V5 antibodies. PARK7 localized both in the cytoplasm and nucleus in C2C12 cells. (PDF 69Â kb)
Les réadmissions en médecine interne; un indicateur de la qualité des soins ?
Creators: name: Kossovsky, Michel
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/618.97
Réadmission
qualité des soins
complexité bio psychosociale

description: Les réadmissions précoces non programmées (survenant dans les 30 jours après une hospitalisation initiale) sont souvent vues comme un indicateur de la qualité des soins. Ce travail expose les limites actuelles des réadmissions en tant qu'indicateur de la qualité des soins. Tout d'abord en constatant que seules les réadmissions potentiellement évitables sont porteuse d'une information permettant éventuellement de juger de la qualité des soins. Ensuite en constatant que l'évaluation de la qualité technique seule des soins intra hospitaliers ne permet pas de prédire une réadmission. Nous concluons en exposant que des facteurs liés aux patients ou à son environnement sont vraisemblablement liés au phénomène des réadmissions. Dès lors des interventions visant à réduire la fréquence des réadmission doivent les prendre en compte.
Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases
Creators: name: Burke, Ashley A.
name: Severson, Elizabeth S.
name: Mool, Shreya
name: Bucaro, Maria J. Solares
name: Greenaway, Frederick T.
name: Jakobsche, Charles E.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Lysyl oxidase has emerged as an important enzyme in cancer metastasis. Its activity has been reported to become upregulated in several types of cancer, and blocking its activity has been shown to limit the metastatic potential of various cancers. The small-molecules phenylhydrazine and β-aminopropionitrile are known to inhibit lysyl oxidase; however, issues of stability, toxicity, and poorly defined mechanisms limit their potential use in medical applications. The experiments presented herein evaluate three other families of hydrazine-derived compounds – hydrazides, alkyl hydrazines, and semicarbazides – as irreversible inhibitors of lysyl oxidase including determining the kinetic parameters and comparing the inhibition selectivities for lysyl oxidase against the topaquinone-containing diamine oxidase from lentil seedlings. The results suggest that the hydrazide group may be a useful core functionality that can be developed into potent and selective inhibitors of lysyl oxidase and eventually find application in cancer metastasis research.
Additional file 2: of OCEAN-C: mapping hubs of open chromatin interactions across the genome reveals gene regulatory networks
Creators: name: Li, Tingting
name: Jia, Lumeng
name: Cao, Yong
name: Chen, Qing
name: Li, Cheng
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology

description: Table S1. Summary of OCEAN-C, FAIRE-seq, Hi-C, and RNA-seq data. (PDF 19Â kb)
Additional file 8: of Identification of genes directly responding to DLK1 signaling in Callipyge sheep
Creators: name: Yu, Hui
name: Waddell, Jolena
name: Kuang, Shihuan
name: Tellam, Ross
name: Cockett, Noelle
name: Bidwell, Christopher
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Cellular localization of METTL21E and GW-CAT. C2C12 cells were transfected with pMETTL21E-pcDNA3.2 /V5 construct (A to C) or pGWCAT- pcDNA3.2/V5 (D to F) and stained with anti-METTL21E or anti-GW-CAT antibody (green), and DAPI (nuclei, blue). METTL21E (A to C) localized both in the cytoplasm and nucleus but mostly accumulated in cytoplasm in C2C12 cells. GW-CAT (D to F) localized mostly in nucleus. (PDF 51Â kb)
Additional file 3: of OCEAN-C: mapping hubs of open chromatin interactions across the genome reveals gene regulatory networks
Creators: name: Li, Tingting
name: Jia, Lumeng
name: Cao, Yong
name: Chen, Qing
name: Li, Cheng
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Table S2. Summary of HOCI and gene expression data analysis. (PDF 22Â kb)
Additional file 4: of OCEAN-C: mapping hubs of open chromatin interactions across the genome reveals gene regulatory networks
Creators: name: Li, Tingting
name: Jia, Lumeng
name: Cao, Yong
name: Chen, Qing
name: Li, Cheng
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology

description: Table S3. Information of public data used in this study. (PDF 20Â kb)
Ions in liquid crystals doped with nanoparticles: conventional and counterintuitive temperature effects
Creators: name: Garbovskiy, Yuriy
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: The concentration of ions in liquid crystals with fully ionised ionic contaminants does not depend on the temperature. Nanoparticles dispersed in the same liquid crystals change the number of mobile ions through the temperature-dependent adsorption/desorption process. As a result, the concentration of ions in liquid crystal nanocolloids is a strong function of their temperature. This type of temperature dependence is governed by the values of the adsorption activation energy and desorption activation energy. A commonly observed scenario is an increase in the concentration of mobile ions in liquid crystal nanocolloids as their temperature goes up. In this article, an opposite effect is modelled. Under certain conditions, the concentration of ions in liquid crystal nanocolloids decreases with increasing temperature. This unusual behaviour is analysed considering liquid crystals doped with both 100% pure and contaminated nanoparticles.
A Deep Technical Review of nZDC Fault Tolerance
Creators: name: Liao, M
name: Ainsworth, S
name: Mukhanov, L
name: Jones, TM
Publisher: name: ACM
Year: 2025
Subjects: 46 Information and Computing Sciences
3301 Architecture
33 Built Environment and Design
4612 Software Engineering
16 Peace, Justice and Strong Institutions

description: Faults within CPU circuits, which generate incorrect results and thus silent data corruption, have become endemic at scale. The only generic techniques to detect one-time or intermittent soft errors, such as particle strikes or voltage spikes, require redundant execution, where copies of each instruction in a program are executed twice and compared. The only software solution for this task that is open source and available for use today is nZDC, which aims to achieve “near-zero silent data corruption” through control- and dataflow redundancy. However, when we tried to apply this to large-scale workloads, we found it suffered a wide set of false positives, negatives, compiler bugs and run-time crashes, which meant it was impossible to benchmark against. This document details the wide set of fixes and workarounds we had to put in place to make nZDC work across full suites. We provide many new insights as to the edge cases that make such instruction duplication tricky under complex ISAs such as AArch64 and their similarly complex ABIs. Evaluation across SPECint 2006 and PARSEC with our extensions takes us from no workloads executing to all bar four, with 2× and 1.6× geomean overhead respectively relative to execution with no fault tolerance.
Lyotropic liquid crystal-assisted synthesis of micro- and nanoparticles of silver
Creators: name: S. Umadevi
name: R. Umamaheswari
name: V. Ganesh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A simple, one-step approach for the synthesis of micro- and nanoparticles of silver by employing a lyotropic liquid crystal (LLC) template is described. Anisotropic silver particles are synthesised by reducing an appropriate amount of precursor silver nitrate using a mild reducing agent ascorbic acid in presence of a hexagonal LLC medium, without the aid of any external stabilising agents. In this synthesis, precursor concentration, type of the reducing agent and LLC phase are found to significantly influence the particle size and morphology. Either a decrease in the concentration of silver nitrate or a change in the reducing agent, from ascorbic acid to sodium borohydride in the same reaction medium, yielded quasi-spherical nanoparticles. Besides, replacing the hexagonal LLC medium with a lamellar phase during the synthesis using ascorbic acid also resulted in the formation of spherical particles in nanometre scale. As a comparison, gold nanoparticle synthesis is carried out in hexagonal and lamellar LLC phases. Similar to the observations made in the silver particle synthesis, branched anisotropic particles are formed in the hexagonal phase and quasi-spherical particles are produced in the lamellar phase. A possible growth mechanism for the formation of these particles based on the phase structure of the LLC medium is discussed.
State-of-the-Art Computational Methodology for Modelling Processes in the Earth's Mantle
Creators: name: Puckett, Elbridge Gerry
name: Billen, Magali I.
name: He, Ying
name: Robey, Jon M.
name: Lokavarapu, Harsha
name: Gassmöller, Rene
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 490303
subject: Numerical solution of differential and integral equations
classificationCode: 370604
subject: Geodynamics
classificationCode: 379999
subject: Other earth sciences not elsewhere classified
classificationCode: 401204
subject: Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics)
classificationCode: 461299
subject: Software engineering not elsewhere classified
classificationCode: 461306
subject: Numerical computation and mathematical software

description: This is a poster describing three algorithms or Scientific Software Elements (SSEs) for computing / modelling processes in the Earth's Mantle. These SSEs have been implemented in the open source code ASPECT, which is a carefully parallelized Finite Element code with Adaptive Mesh Refinement (AMR) for modeling problems in the Earth's mantle. Two of these SSEs have never before been implemented in a code for modeling convection in the Earth's mantle, namely (1) a Volume-of-Fluid interface tracking algorithm and (2) a Bound Preserving Discontinuous Galerkin method. We also describe our implementation of an active tracer particle method in ASPECT and present a method for load balancing the combination of AMR and the work done to use the particles in a computation. We present the results of computations of several standard benchmark problems in computational mantle dynamics with these SSEs.
Human–wildlife conflict and attitude of local people towards conservation of wildlife in Chebera Churchura National Park, Ethiopia
Creators: name: Aberham Megaze
name: Mundanthra Balakrishnan
name: Gurja Belay
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Human–wildlife conflict is a serious challenge undermining the integrity of protected areas in developing countries. Developing effective human–wildlife conflict mitigation strategies requires an understanding of the conflict patterns, species involved and attitudes of local people living along protected area boundaries. We hypothesised that (1) there was a high level of human–wildlife conflict and (2) the local people would have less favourable attitudes towards problematic wild animals. We assessed patterns of human–wildlife conflict and attitudes of local people along the boundary of Chebera Churchura National Park, Ethiopia from 2012 to 2014. A total of 354 households were selected randomly for interview. A questionnaire survey, focus group discussions and direct field observations were carried out in the selected villages. The major types of human−wildlife conflict in the area include crop raiding, livestock predation, increased risk of livestock diseases and direct threats to human life. A majority of the respondents (68.1%) faced crop damage and domestic animal loss, 12.3% reported threat to humans and 0.3% reported that the wildlife might cause diseases. Close proximity of the villages to the park and seasons influenced livestock predation intensity with highest predation in the wet season (56.0%). To mitigate these problems, the local people utilised various traditional methods, including guarding. Most respondents had positive attitudes towards the conservation of wildlife. However, as the frequency of conflicts increased in the last five years, the attitudes of local people might change. Active measures are to be implemented to mitigate the problem and safeguard the future of the wildlife around the park. The park has enormous potential to benefit more local people by implementing a participatory management approach to conservation.
Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
Creators: name: Park, Ji-Young
name: Yuk, Heung Joo
name: Ryu, Hyung Won
name: Lim, Su Hwan
name: Kim, Kyung Su
name: Park, Ki Hun
name: Ryu, Young Bae
name: Lee, Woo Song
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine proteases. The isolated compounds were broussochalcone B (1), broussochalcone A (2), 4-hydroxyisolonchocarpin (3), papyriflavonol A (4), 3′-(3-methylbut-2-enyl)-3′,4,7-trihydroxyflavane (5), kazinol A (6), kazinol B (7), broussoflavan A (8), kazinol F (9), and kazinol J (10). All polyphenols were more potent against papain-like protease (PLpro) than against 3-chymotripsin-like protease (3CLpro); therefore, we investigated their structural features that were responsible for this selectivity. Compound 4 was the most potent inhibitor of PLpro with an IC50 value of 3.7 μM. The active compounds displayed kinetic behaviors, and the binding constants of their interaction with PLpro were determined from surface plasmon resonance analysis. Our results suggest B. papyrifera constituents as promising candidates for development into potential anti-coronaviral agents.
Characterising the present-day stress regime of the Georgina Basin
Creators: name: A. Bailey
name: E. Tenthorey
name: B. Ayling
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: The onshore Georgina Basin in northern Australia is prospective for unconventional hydrocarbons; however, like many frontier basins, it is underexplored. A well-connected hydraulic fracture network has been shown to be essential for the extraction of resources from the tight reservoirs that categorise unconventional plays, as they allow for economic flows of fluid from the reservoir to the well. One of the fundamental scientific questions regarding hydraulic stimulation within the sub-surface of sedimentary basins is the degree to which local and regional tectonic stresses act as a primary control on fracture propagation. As such, an understanding of present-day stresses has become increasingly important to modern petroleum exploration and production, particularly when considering unconventional hydrocarbon reservoirs. This study characterises the regional stress regime in the Georgina Basin using existing well data. Wellbore geophysical logs, including electrical resistivity image logs, and well tests from 31 petroleum and stratigraphic wells have been used to derive stress magnitudes and constrain horizontal stress orientations. Borehole failure features interpreted from wellbore image and caliper logs yield a maximum horizontal stress orientation of 044°N. Integration of density log data results in a vertical stress gradient of 24.6 MPa km–1. Leak-off and mini-fracture tests suggest that this is the minimum principal stress, as leak-off values are generally shown to be at or above the magnitude of vertical stress. The maximum horizontal stress gradient is calculated to be in the range of 31.3–53.9 MPa km–1. As such, a compressional stress regime favouring reverse/reverse–strike-slip faulting is interpreted for the Georgina Basin.
The Migration Security Map of Ukraine 2016
Creators: name: Kateryna Kulchytska (Europe Without Barriers NGO)
Publisher: name: figshare
Year: 2017
Subjects: subject: 160303 Migration
subject: FOS: Sociology

description: The research is based on the methodology that was used by the European Commission in 2014 and 2015 for the fifth and sixth reports on Ukraine’s progress in implementing the Action Plan on visa liberalisation and includes evaluation of regular and irregular migration from Ukraine to the EU, as well as evaluating the number of asylum seekers in the EU.
In particular, the following indicators are analyzed: Regular migration Visa applications Refusal of entry at the border Ukrainian detection of irregular migrants Number of asylum seekers Decisions on providing an asylumReadmission
Additional file 1: of The polymorphisms of LCR, E6, and E7 of HPV-58 isolates in Yunnan, Southwest China
Creators: name: Xi, Juemin
name: Chen, Junying
name: Xu, Miaoling
name: Yang, Hongying
name: Wen, Songjiao
name: Pan, Yue
name: Wang, Xiaodan
name: Ye, Chao
name: Qiu, Lijuan
name: Sun, Qiangming
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Table S1. The PCR primers for validating the variations of HPV-58 LCR, E6 and E7. (DOC 33Â kb)
Additional file 1: of SSR marker development and intraspecific genetic divergence exploration of Chrysanthemum indicum based on transcriptome analysis
Creators: name: Han, Zhengzhou
name: Ma, Xinye
name: Wei, Min
name: Zhao, Tong
name: Zhan, Ruoting
name: Chen, Weiwen
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology

description: Some information extracted from the doctoral thesis about phenotypic difference betwwen two C. indicum germplasms. (DOCX 2701 kb)
Modeling experiment crop coefficients hydrological modeling
Creators: name: Hunink, Johannes
name: Eekhout, Joris
Publisher: name: figshare
Year: 2017
Subjects: Hydrology

description: Inputs and outputs of a modeling experiment on crop parameterization and hydrological modeling. Climate forcings are in a separate file due to size. Formats: PC-RASTER, ASCII and Python

Please check the readme.pdf for more details
MOESM1 of Salinity effect on the metabolic pathway and microbial function in phenanthrene degradation by a halophilic consortium
Creators: name: Wang, Chongyang
name: Huang, Yong
name: Zhang, Zuotao
name: Wang, Hui
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Accession numbers of the cloned catabolic gene sequences. Figure S1. Relative expression levels of genes encoding RHD, C12O, C23O, P34O, and G12O during phenanthrene degradation under different salinity. The transcript/gene ratios were calculated for the microcosm incubation. Three independent experiments were performed (error bars are not shown). A: Relative expression of genes encoding RHD; B: Relative expression of genes encoding C12O; C: Relative expression of genes encoding P34O; D: Relative expression of genes encoding C23O; E: Relative expression of genes encoding G12O.
Additional file 1: of Associations among unit leadership and unit climates for implementation in acute care: a cross-sectional study
Creators: name: Shuman, Clayton
name: Liu, Xuefeng
name: Aebersold, Michelle
name: Tschannen, Dana
name: Banaszak-Holl, Jane
name: Titler, Marita
Publisher: name: figshare
Year: 2018
Subjects: subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Data Collection Timeline. (PDF 51 kb)
X‐ray‐computed radiography and tomography study of electrolyte invasion and distribution inside pristine and heat‐treated carbon felts for redox flow batteries
Creators: name: Gebhard, Marcus
name: Schnucklake, Maike
name: Hilger, André
name: Röhe, Maximilian
name: Osenberg, Markus
name: Krewer, Ulrike
name: Manke, Ingo
name: Roth, Christina
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: carbon felts
subject: contact angle measurements
subject: electrolyte wetting
subject: thermal treatments
subject: vanadium redox flow batteries
subject: X-ray radiographies
subject: X-ray tomographies
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::541 Physikalische Chemie

description: Porous carbon felts (CFs) are widely used electrode materials for vanadium redox flow batteries (VRFBs). These materials differ in their precursor material, thickness, or graphitization degree and demonstrate broad differences in electrochemical performance. Prior to operation, an activation step, such as acid or heat treatment (HT), is commonly performed to improve their performance. A thermal treatment in air functionalizes the surface of the electrode and improves reaction kinetics as well as the wettability of the electrode. Herein, pristine and heat‐treated CFs are compared regarding their electrolyte wetting behavior for the use in VRFB. Contact angle (CA) measurements are conducted ex situ to investigate the effect of the HT. Furthermore, the porous CFs are examined in situ with an in‐house‐built flow cell regarding their invasion behavior with different types of electrolytes by X‐ray radiography. Additionally, the distribution of the electrolyte inside the felts is investigated by X‐ray tomography. The results demonstrate the effect of the HT and choice of electrolyte on the wetting behavior and electrolyte distribution.
Saliva and Serum Protein Adsorption on Chemically Modified Silica Surfaces
Creators: name: Lehnfeld, Jutta
name: Dukashin, Y.
name: Mark, J.
name: White, G. D.
name: Wu, S.
name: Katzur, Verena
name: Müller, Rainer
name: Ruhl, S.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: biomaterials, surface properties, self-assembled monolayers, pellicle, protein amount, protein composition
subject: 540 Chemie

description: Biomaterials, once inserted in the oral cavity, become immediately covered by a layer of adsorbed proteins that consists mostly of salivary proteins but also of plasma proteins if the biomaterial is placed close to the gingival margin or if it becomes implanted into tissue and bone. It is often this protein layer, rather than the pristine biomaterial surface, that is subsequently encountered by colonizing bacteria or attaching tissue cells. Thus, to study this important initial protein adsorption from human saliva and serum and how it might be influenced through chemical modification of the biomaterial surface, we have measured the amount of protein adsorbed and analyzed the composition of the adsorbed protein layer using gel electrophoresis and western blotting. Here, we have developed an in vitro model system based on silica surfaces, chemically modified with 7 silane-based self-assembled monolayers that span a broad range of physicochemical properties, from hydrophilic to hydrophobic surfaces (water contact angles from 15° to 115°), low to high surface free energy (12 to 57 mN/m), and negative to positive surface charge (zeta potentials from –120 to +40 mV at physiologic pH). We found that the chemical surface functionalities exerted a substantial effect on the total amounts of proteins adsorbed; however, no linear correlation of the adsorbed amounts with the physicochemical surface parameters was observed. Only the adsorption behavior of a few singular protein components, from which physicochemical data are available, seems to follow physicochemical expectations. Examples are albumin in serum and lysozyme in saliva; in both, adsorption was favored on countercharged surfaces. We conclude from these findings that in complex biofluids such as saliva and serum, adsorption behavior is dominated by the overall protein-binding capacity of the surface rather than by specific physicochemical interactions of single protein entities with the surface.