cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gender und Bildung. Geschlechtergerechtigkeit als Qualitätskriterium
Creators: name: Leemann, Regula Julia
Publisher: name: Julius Klinkhardt
Year: 2015
Subjects: subject: Geschlecht
subject: Bildung
subject: Qualität
subject: Geschlechtergerechtigkeit
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Der Aufsatz befasst sich mit der Thematik von Geschlechtergerechtigkeit als Qualitätskriterium im Kontext von Schule und Bildung. In einem ersten Schritt wird ein Vorschlag für die Definition von Geschlechtergerechtigkeit gemacht, wobei darauf verweisen wird, dass diese immer einer normativen Setzung unterliegt. Die dargelegte Systematik erlaubt es, Handlungsimplikationen für die pädagogische Profession abzuleiten. Anschließend wird gezeigt, wie der Stand der Geschlechtergerechtigkeit (Qualität) in Evaluationen oder in einem Monitoring systematisch erfasst werden kann. Auf der Basis einer eigenen empirischen Studie geht das Kapitel zum Schluss der Frage nach, wie der Qualitätsdiskurs um Geschlechtergerechtigkeit auf die Bildungsakteure wirkt und wie Schulen sich gegenüber den gesellschaftlichen Erwartungen an Geschlechtergerechtigkeit positionieren.
Supplementary material 5
Creators: name: Forthman, Michael
name: Weirauch, Christiane
Publisher: name: figshare
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Parsimony ancestral state reconstruction of colour character 2 on the ML phylogram (tree converted to cladogram for visual). Terminal taxa coded as cryptic (black) or either aposematic, metallic, or aposematic and metallic (blue).
Evaluating the genotoxic potential of oligonucleotide pharmaceuticals
Creators: name: Reshat, Reshat
Publisher: name: Imperial College London
Year: 2012

description: According to regulatory guidelines, routine genotoxicity tests are not appropriate for biotechnology derived pharmaceuticals, including oligonucleotide based therapeutics, as they are not expected to interact with genomic DNA. However, reports of oligonucleotides capable of binding duplex DNA in a sequence specific manner to form triple-helix (triplex) or displacement-loop (D-loop) structures that in turn cause mutation have raised concern. The European Medicines Agency (EMA) has questioned the capability of antisense oligonucleotide (ASO) therapeutics to form such structures at genomic DNA. Additionally, concern has been expressed regarding the fate of chemically modified ASO degradation products (nucleotide analogues). It is well established that non-canonical antiretroviral nucleoside analogues, employed in antiretroviral therapy, result in gross chromosome aberrations following incorporation into genomic DNA. This study has addressed these concerns by evaluating the genotoxic potential of a triplex forming oligonucleotide (TFO) and a D-loop forming ASO targeting genomic DNA. Furthermore, the incorporation efficiency and genotoxicity of nucleotide analogues derived from ASO degradation was investigated. Data presented here demonstrate a TFO targeting genomic DNA was not capable of inducing mutation above the detection limit of this assay. However, a biologically active ASO molecule induced sequence specific mutation ~4.4 fold above control in a system where RAD51 protein expression was induced. Additionally, DNA polymerase was capable of incorporating various ASO derived nucleotide analogues into a primed DNA template with reduced efficiency. Treatment with phosphorothioate nucleotide analogue, one of the most common chemical modifications used in ASO design, induced mutation ~100 fold above control. To conclude, ASO and their putative degradation products appeared to be capable of off-target mutagenesis providing favourable conditions were met. However, as genotoxicity data has been presented for a single ASO and nucleotide analogue, it seems plausible to suggest this work can provide a foundation to test future ASO therapeutics and putative degradation products.
title: Die Zukunft der Urologie: Demographie und 12 Monate Überlebensrate von stationären neunzigjährigen Patienten
Creators: name: Madersbacher, S.
name: Luef, T.
name: Eredics, K.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Innerhalb der nächsten 30 Jahre kommt es in Österreich zu einer 175%igen Zunahme von 90+ Patienten. Dieser demographische Wandel wird zu einer deutlichen Zunahme von hochbetagten Patienten führen, die stationär aufgenommen werden müssen. In der Literatur[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Electrophysiological study of dopamine neurons in the dorsal raphe nucleus & ventrolateral periaqueductal grey
Creators: name: Matthews, Gillian Anne Caroline
Publisher: name: Imperial College London
Year: 2012

description: The midbrain dopamine system plays a fundamental conserved role in regulating behaviour, and its dysfunction is associated with several neuropsychiatric disorders including addiction, schizophrenia, and Parkinson’s Disease. Midbrain dopamine neurons display considerable heterogeneity in their neurochemical, electrophysiological, and functional properties, and project to many cortical and subcortical structures. The majority of these neurons reside within the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA), but a less well-known, and understudied, dopamine population are housed within the dorsal raphe nucleus (DRN) and ventrolateral periaqueductal grey (vlPAG). These neurons provide the majority of the dopaminergic input to the central extended amygdala and have been implicated in the sleep-wake cycle and mediating the effects of opiates. However, their electrophysiological properties have not been examined. I have studied these neurons in mice using immunohistochemistry and electrophysiology in an acute brain slice preparation ex vivo. I found that they display similar properties to some VTA dopamine neurons, and noted co-expression of vasoactive intestinal peptide in a subset of this population. A characteristic feature of VTA dopamine neurons is the potentiation observed at glutamatergic synapses following a single dose of addictive drug or an acute stress experience. I investigated whether DRN/vlPAG dopamine neurons would show cocaine-induced plasticity and found that glutamatergic synapses were potentiated not only by a single dose of cocaine, but also by acute social isolation. This potentiation was associated with a change in AMPAR transmission, which is similar to that observed following cocaine in the VTA. I also investigated the hypothesis that this plasticity is a result of acute anxiety using behavioural analysis and administration of anxiolytic compounds. These findings suggest another form of salient stimulus which can induce plasticity in dopamine neurons, and have relevance to several neuropsychiatric diseases including those modelled by social isolation.
Renal Care in Saudi Arabia: A Review of the Quality of Healthcare Management
Creators: name: Hassanien, Amal
Publisher: name: Imperial College London
Year: 2013

description: Chronic kidney disease has become a worldwide public health problem as it is linked with an increase in the incidence and prevalence rate of patients with renal failure who require renal replacement therapy with high healthcare costs and poor outcomes. Moreover, chronic kidney disease (CKD) in its earlier stages is associated with a higher prevalence of many adverse outcomes such renal failure, cardiovascular disease, and premature death. In Saudi Arabia, the total number of patients who are receiving renal replacement therapy has been increasing rapidly in recent decades, as the Saudi Centre for Organ Transplantation data has demonstrated, while the estimated annual cost for treating end-stage renal disease uses around 3.8% of the total Ministry of Health’s budget in Saudi Arabia. This means that more attention is required for the prevention and management of CKD and its risk factors in Saudi Arabia. Therefore, this thesis was formulated to review the quality of healthcare management for patients with chronic kidney disease in Saudi Arabia. This review was achieved based on: (I) assessing and describing the epidemiology of end-stage renal disease, (II) assessing pre end-stage renal disease care practice, (III) examining the indications for hospital admission among haemodialysis patients. The findings have revealed that the burden of end-stage renal disease has increased substantially in Saudi Arabia particularly among middle-aged diabetic and hypertensive patients, while the most prevalent co-morbid conditions were hypertension and Hepatitis C virus infection. Detecting patients with chronic kidney disease in the earlier stages, and pre end-stage renal disease care practices and its outcomes should be improved in Saudi Arabia. Furthermore, cardiovascular diseases play a major role in increasing the rate of hospitalization and mortality among patients with end-stage renal disease. In conclusion, this review stressed the needs and the importance of multidisciplinary preventive strategies for leading causes of end stage renal disease (ESRD) and improving pre ESRD nephrology care practices and its outcomes in Saudi Arabia. This will not be possible to achieve without collaboration between healthcare providers and a comprehensive national health information system to allow consistent assessment of the quality of healthcare management and provide an updated evidence-based health policy that will help healthcare providers to choose the best intervention that will help to improve healthcare practice outcomes and allocate healthcare resources.
Aetiology of an Unknown Liver Disease in Northern Ethiopia
Creators: name: Robinson, Oliver James Kaldor
Publisher: name: Imperial College London
Year: 2012

description: Cases of a novel form of liver disease, localised to a cluster of villages in the Tigray region of Northern Ethiopia, were first reported in 2001. Up to January 2010, 591 cases were recorded, including 228 deaths. Symptoms include epigastric and abdominal swelling. Children are particularly susceptible, with some children having died within three months of the onset of symptoms, whereas some adults report living with the disease for many years. The pattern of spread suggested an environmental toxin was the causative agent, with investigations implicating the plant toxins, pyrrolizidine alkaloids. The ultimate aim of the research presented in this thesis was to determine the aetiology of the disease and a multi-disciplinary approach, involving clinical research, ethnography, biochemical and metabonomic analysis and toxicology, has been employed to achieve this. The disease was first characterised clinically: The disease presents with epigastric pain, initial bloody diarrhoea and progressive ascites with either hepatomegaly or splenomegaly or both. Histology of liver biopsy specimens revealed centrilobular necrosis in acute cases and bile ductular proliferation and fibrosis in chronic cases. Biochemical analysis identified γ-glutamyl transferase as a sensitive indicator of the disease. Ethnographic investigation of the lifestyle of the residents of the affected villages revealed a monotonous diet, the presence of a similar disease among livestock and suggested millet and animal products as potential sources of exposure to the aetiological agent(s). The pesticide DDT was identified as a further potential risk factor for the disease. A global metabonomic analysis of patient urine samples using 1H NMR spectroscopy was conducted and several metabolites associated with the disease were identified. Targeted LC-MS assays were then developed to detect pyrrolizidine alkaloid exposure among patients, either through detection of the parent alkaloid, acetyllycopsamine (AL), in urine samples or extraction and detection of pyrrolic metabolite adducts from whole blood. Relative AL urinary concentrations were found to be significantly higher among cases. AL was shown to be hepatotoxic in the mouse model, and at high doses induced centrilobular hepatic necrosis and metabolic changes similar to that observed in the human disease. Finally, DDT was detected at high levels in patient urine and serum samples. DDT was shown to substantially enhance the toxic effects of AL in the mouse model, through induction of the CYP3A11 enzyme, and in combination with AL induced liver pathology closely resembling the human disease. In conclusion, the available evidence suggests that the disease arises from co-exposure to DDT and pyrrolizidine alkaloids, including AL.
“So I had to give it up”. The role of social support for career persistence or attrition in a qualitative sample of second career teachers
Creators: name: Bauer, Catherine
name: Trösch, Larissa Maria
name: Aksoy, Dilan
Publisher: name: Schweizerische Gesellschaft für Bildungsforschung
Year: 2021
Subjects: subject: Second career teachers
subject: Early career teachers
subject: Social support
subject: Teacher attrition
subject: Job demands-resources model
subject: 370 - Erziehung, Schul- und Bildungswesen

description: This qualitative study uses the Job Demands-Resources framework to examine social support and its role in career retention or attrition among Swiss second career teachers (SCTs). In many countries, including Switzerland, great efforts are made to bring professionals from other occupational fields into teaching. As a result, the number of SCTs is growing, as are speculations about their skills, resources, and career persistence. A qualitative content analysis of 23 semi-structured interviews shows that support from colleagues and principals is a crucial job resource for SCTs, but seems to be positively associated with work engagement and career retention only if it is offered in forms that are sensitive to SCTs’ own needs and skills. Implications for SCT training and job induction are discussed.
The Effect of Biomimetic Tissue Engineering Constructs on the Phenotype of Immature Cardiomyocytes
Creators: name: Rao, Christopher
Publisher: name: Imperial College London
Year: 2013

description: Several studies have suggested that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) and human embryonic stem cell-derived cardiomyocytes (hESC-CM) are sufficiently comparable to adult myocardium to facilitate application in a wide range of toxicology, drug development and disease modelling applications. Evidence from the literature is however, inconstant. We tested the hypothesis that iPSC-CM and hESC-CM have a predictable and consistent response to pharmacological manipulation, finding in many instances this was not true. We then focused on methods to improve the maturity of iPSC-CM, in particular, on the effect of cell alignment on intra-cellular Ca2+ cycling. For much of the exploratory work and validation of the techniques we used neonatal rat ventricular myocytes (NRVM). They are more readily available than iPSC-CM and have similar properties. We hypothesized that cell alignment of immature cardiomyocytes, in a fashion analogous to the adult myocardium, would improve the speed of intra-cellular Ca2+ cycling. We found that structured culture modulated Ca2+ cycling in iPSC-CM, and that this was probably due to improvements in sarcoplasmic reticulum Ca2+ release mechanisms. In contrast to NRVM, structured culture did not appear to have a significant effect on Ca2+ extrusion mechanisms in iPSC-CM. Furthermore, we found that the physical properties of the constructs made it difficult to fully explore the mechanisms underlying these experimental findings. Consequently, we developed and validated novel constructs which would facilitate exploration of the mechanisms underlying the association between cell-alignment and the functional properties of immature cardiomyocytes. These findings suggest that tissue engineering approaches are likely to be relevant to in vitro modelling with iPSC-CM. An important next step will be to conclusively demonstrate that these techniques overcome the limitations of iPSC-CM highlighted in the first part of this thesis, and improve their efficacy for myocardial disease modelling.
Characterization of the Endometrium of Women with Reproductive Failure
Creators: name: Salker, Madhuri Sonal
Publisher: name: Imperial College London
Year: 2012

description: Differentiation of human endometrial stromal cells (HESCs) into decidual cells represents a highly coordinated process essential for embryo implantation. Following the post-ovulatory rise in progesterone levels HESCs undergo biochemical and morphological transformation in a process known as decidualization. It heralds the end of the mid-secretory phase implantation window, defined as the limited period during which progesterone-driven changes in the luminal epithelium allow apposition, attachment and invasion of a developmentally competent blastocyst. Failure of the endometrium to acquire a receptive phenotype is widely viewed as a major cause of infertility and IVF treatment failure. Conversely, recurrent pregnancy loss (RPL) is associated with impaired decidualization. Firstly, analysis of mid-secretory endometrial biopsies from RPL patients demonstrated that there is a decreased expression of the decidual marker, Prolactin but increased levels of pro-inflammatory cytokine, Prokineticin-1. Secondly, HESCs were then identified to mount a highly coordinated but transient inflammatory response that renders the endometrium receptive, by rapidly releasing Interleukin-33, up-regulating its cognate transmembrane receptor-ST2L and other pro-inflammatory mediators before mounting an anti-inflammatory response that includes down-regulation of ST2L and increased secretion of the soluble decoy receptor sST2. In agreement, only during the transient pro-inflammatory phase of the decidual process did HESCs secrete factors conducive to implantation in mice. Failure of HESCs to constrain this pro-inflammatory response appeared to prolong the implantation window and was associated with RPL. Furthermore, deregulated Serum and Glucocorticoid Kinase 1 (SGK1) activity in the endometrium during the window of implantation either interfered with embryo implantation, leading to infertility, or compromised the integrity of the decidual-placental interface, resulting in pregnancy loss. A constitutively active SGK1 mutant was expressed in luminal epithelial cells of the mouse uterus; perturbing uterine fluid handling and abolished embryo implantation. However, implantation was not impaired in Sgk1-deficient mice, although there was evidence of fetal demise. RPL was also associated with lower SGK1 induction in decidualizing HESCs and impaired expression of oxidative stress defence genes. In summary, impaired decidualization or unfettered endometrial receptivity carries an obvious risk of implantation of developmentally delayed or compromised embryos thus triggering a spectrum of pathological events, leading to miscarriage or predisposing for obstetrical complications. Together, these findings provide fundamental insights of uterine receptivity and describe a novel paradigm of reproductive failure with potentially far-reaching clinical implications.
Metabolic biomarkers of colorectal cancer
Creators: name: Alfa-Wali, Maryam
Publisher: name: Imperial College London
Year: 2012

description: Colorectal cancer (CRC) remains a major public health problem with advanced and recurrent disease being a management challenge due to the lack of efficacy of currently available monitoring tools. Carcinoembryonic antigen is used as a marker for recurrent disease but has limited sensitivity. Early sensitive markers of disease severity and recurrence are required. The aim of this thesis was to identify potential metabolic biomarkers of CRC patients using ‘Metabonomics’ based on proton nuclear magnetic resonance (1H NMR) spectroscopy. The breadth of 1H NMR metabonomics exploring different aspects of CRC pathogenesis was investigated. A global approach profiling a large number of metabolites was undertaken in cell line and chemoprevention studies with subsequent targeted profiling experiments using human polypoid tissue samples. The studies primarily exhibited changes in choline and lipids to be associated with CRC. Although these metabolites are well reported, this thesis presents contemporary metabolic profiling using systems not previously reported. Tumour extracts of CRC xenografts showed higher levels in the ratio of phosphocholine and glycerophosphocholine between poorly and well-differentiated cell lines. Human tissue and biofluids were used to define metabolic phenotypes. Normal and polypoid colorectal tissues were also metabolically characterised by changes in choline using magic angle spinning (MAS) 1 H NMR. Investigating chemoprevention strategies with bile acids in adenoma patients indicated alterations in short chain fatty acids, related to gut microflora metabolism. In clinical studies, higher levels of lactate and glycoproteins were identified in rectal cancer patients, as potential metabolic predictors of response to chemoradiotherapy. A metabolically translational feature of the thesis in a heterogeneous population confers a significant increase in the risk of CRC incidence with metabolic syndrome (MetS). Thus, inferring identification of MetS components as part of screening measures. In vivo studies provide a functional way of networking metabolic pathways to pathological states, thereby unifying perspectives post hoc.
Effects of parasitic infection on animal learning and memory: a systematic review meta-analysis
Creators: name: Rinsoz, Malika
Publisher: name: figshare
Year: 2017
Subjects: subject: 60805 Animal Neurobiology
subject: FOS: Biological sciences

description: Appendix 1. Literature search and selection procedure Appendix 2. Endnote library. 136 articles firstly selected from the Web of Science literature searches Appendix 3. Raw data files (Memory1.csv & Learning2.csv): all effect sizes included in the meta- analyses Appendix 4. R script of meta-analyses (Memory1.R & Learning2.R) Table S1. Summary of the 11 memory studies excluded on full-text screening Table S2. Summary of the 15+17 learning studies excluded on full-text screening
Cell cycle regulation in mammalian oocytes
Creators: name: Kuleszewicz, Katarzyna
Publisher: name: Imperial College London
Year: 2013

description: An unusual feature of mammalian female germ cells is that they are arrested in meiotic prophase, equivalent to mitotic G2-phase, for an extended period of time. In this thesis I have investigated two aspects of this arrest. First, I examined whether cohesin replenishment is required for the maintenance of chromosome cohesion during protracted meiotic prophase arrest. Nipbl, an evolutionarily conserved protein, is a component of protein complex called kollerin, whose activity in loading cohesin onto chromosomes is necessary for accurate chromosome segregation during mitosis. However, until now its function in mammalian meiosis was unknown. I have showed that Nipbl is present on meiotic chromosomes throughout meiotic prophase in mouse spermatocytes and oocytes and it accumulates at chromosomal axes where it co-localises with cohesin. I employed conditional knockout strategy to inactivate Nipbl gene in mouse oocytes arrested in meiotic prophase. Although functional Nipbl transcripts were efficiently depleted, these oocytes underwent meiotic maturation with unaffected chiasmata and cohesion. Surprisingly, Nipbl-deleted eggs were fertile and the loading of mitotic cohesin containing Rad21 was unaffected in fertilized eggs. Aditionally, these eggs could develop into blastocysts upon parthenogenetic activation, however harbouring a high proportion of cells with misaligned chromosomes. These results suggest that Nipbl is very stable in the oocyte. In the second project we conceived that the maintenance of the cell cycle arrest in primordial oocytes is an important aspect of follicular survival. Previously proposed involvement of the anaphase promoting complex/cyclosome (APC/C), a cell cycle ubiquitin ligase complex in down-regulating the cyclin-dependent kinase activity in fully-grown oocyte led me to inactivate APC/C in dormant oocytes using conditional knockout system. I found that upon APC/C inactivation, primordial follicles were completely depleted before adulthood, within 5 weeks of birth, suggesting that the APC/C activity is required for the survival of primordial oocytes. These results propose the presence of previously unknown mechanism involving APC/C, essential for primordial follicle survival.
Extracellular ATP-Induced Alterations in Extracellular H+ Fluxes From Cultured Cortical and Hippocampal Astrocytes
Creators: name: Choi, Ji-in Vivien
name: Tchernookova, Boriana
name: Kumar, Wasan
name: Kiedrowski, Lech
name: Goeke, Calla
name: Guizzetti, Marina
name: Larson, John
name: Kreitzer, Matthew A
name: Malchow, Robert Paul
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Small alterations in the level of extracellular H+ can profoundly alter neuronal activity throughout the nervous system. In this study, self-referencing H+-selective microelectrodes were used to examine extracellular H+ fluxes from individual astrocytes. Activation of astrocytes cultured from mouse hippocampus and rat cortex with extracellular ATP produced a pronounced increase in extracellular H+ flux. The ATP-elicited increase in H+ flux appeared to be independent of bicarbonate transport, as ATP increased H+ flux regardless of whether the primary extracellular pH buffer was 26 mM bicarbonate or 1 mM HEPES, and persisted when atmospheric levels of CO2 were replaced by oxygen. Adenosine failed to elicit any change in extracellular H+ fluxes, and ATP-mediated increases in H+ flux were inhibited by the P2 inhibitors suramin and PPADS suggesting direct activation of ATP receptors. Extracellular ATP also induced an intracellular rise in calcium in cultured astrocytes, and ATP-induced rises in both calcium and H+ efflux were significantly attenuated when calcium re-loading into the endoplasmic reticulum was inhibited by thapsigargin. Replacement of extracellular sodium with choline did not significantly reduce the size of the ATP-induced increases in H+ flux, and the increases in H+ flux were not significantly affected by addition of EIPA, suggesting little involvement of Na+/H+ exchangers in ATP-elicited increases in H+ flux. Given the high sensitivity of voltage-sensitive calcium channels on neurons to small changes in levels of free H+, we hypothesize that the ATP-mediated extrusion of H+ from astrocytes may play a key role in regulating signaling at synapses within the nervous system.
To The Ramparts Of Pratāpagaḍa
Creators: name: RODRIGUES, TENSING CARLOS
Publisher: name: figshare
Year: 2017
Subjects: subject: 210302 Asian History
subject: FOS: History and archaeology
subject: History
subject: Anthropology
subject: FOS: Sociology

description: Putting together all the above information, the seamless unity of the Marāthā and Seuna Yādava is a foregone conclusion. The Hōyasāḷa of Dōrasamudra complete the yāḍava triad – Hōyasāḷa, Sēūṇa and Marāthā - that dominated the political, social and cultural panorama of the Deccan for over eight centuries - from the end of the 10th century CE to the end of the 18th century CE. [The Yādavarāyā, 27 Aug 17] Add to it the Vijayānagara kings, and you see the all-pervasive yāḍava presence for almost a millennium. [The Dhangar Dynasties Of Deccan, 13 Aug 17] And there is nothing surprising about it; it was a natural evolution of a ubiquitous pastoral community. The yāḍava kings arose from the Deccan soil, starting as pastoral chieftains and slowly morphing into monarchs. [Māḷēnaḍu And Māvaḷ, 20 Aug 17] No doubt they fought among themselves; as animal herders they captured herds of cattle, sheep and goats; their heroes became their gods. As kings they captured forts and palaces; their dreams changed the design and the colour of the Deccan tapestry; the yāḍava warp and weft, however, remained constant; they also intermarried.
Five balances in the management of rheumatoid arthritis.pdf
Creators: name: Shengrong Zou
Publisher: name: figshare
Year: 2017
Subjects: Diseases

description: Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in controlling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.
Saisonbereinigung und Trend einer Zeitreihe. Eine mathematisch schl üssige Methode
Creators: name: Vetter, Helmut
Publisher: name: Hochschule für Wirtschaft FHNW
Year: 2017
Subjects: Saisonale Komponente
Trend
Zeitreihe

description: Mathematisch schlüssige Methode Trend und Saisonkomponente einer Zeitreihe zu bestimmen
Kreislaufwirtschaft - Die Zukunft ist zirkulär
Creators: name: Domenig, Fabio
name: Fitze, Curdin Andri
name: Mechan, Jeremiel Ollantay
name: Zaugg, Samuel
Publisher: name: Hochschule für Technik FHNW
Year: 2021
Subjects: subject: KVA Schlacke
subject: Kehrichtverbrennungsanlagen
subject: 624 - Ingenieurbau und Umwelttechnik

description: Die Entwicklung unserer Gesellschaft geht Hand in Hand mit einer steigenden Abfallproduktion. Viele Länder setzen deshalb Kehrichtverbrennungsanlagen ein, welche nicht nur das Volumen des Kehrichts reduziert, sondern dabei auch Strom und Fernwärme produzieren. Was vom Abfall danach übrig bleibt ist KVA-Schlacke, welche nun ihrerseits die Deponien füllt. Um dem Platzmangel in den Deponien Herr zu werden, gibt es Bestrebungen, die Schlacke anderweitig unterzubringen und einen Nutzen aus ihr zu ziehen. Dazu zählen vor allem die Verwendung der Schlacke als Gesteinskörnung im Tief- und Strassenbau und ihre Verwendung in der Zement- und Betonherstellung, wobei in ersterer Anwendung anderen, chemisch unbelasteten Abfällen, wie zum Beispiel unverschmutztes Aushubmaterial, Vorrang gegeben wird. Dazu muss die Schlacke gewisse chemische und physische Voraussetzungen erfüllen. Diese werden zusammen mit den rechtlichen Grundlagen bezüglich der Verwendung von KVA-Schlacke in diesem Bericht untersucht. Besonderes Augenmerk wird dabei auf die Schadstoffgrenzwerte im Zusammenhang mit der Verwendung im Tief- und Strassenbau und in der Zement- und Betonherstellung gerichtet. KVA-Schlacke enthält noch viele Wertstoffe, wie unter anderem Eisen und Aluminium. Um diese Stoffe neben den herkömmlichen Trennmethoden noch effizienter und vollständiger zu extrahieren, wird das SELFRAG-Verfahren angewendet. Dieses Verfahren reduziert das Volumen der Schlacke durch die Entfernung verschiedener Bestandteile noch weiter und verändert ihre stoffliche Zusammensetzung. Diese veränderte Restschlacke wird ebenfalls auf ihre Verwendungsmöglichkeiten untersucht.
Description
Creators: name: Lavier, Dorian
Publisher: name: OSF Registries
Year: 2022

description: We are looking at if behaving unethically negatively affects an individual's self perception. The purpose of this is to see how behavior affects self perception. To examine this we will have participants take two separate tests, one where they will have the opportunity to cheat and another where they will not be able to cheat. We will measure their levels of self perception before and after each test and compare the results.
Supplementary material 1
Creators: name: Forthman, Michael
name: Weirauch, Christiane
Publisher: name: figshare
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Species of Ectrichodiinae that were assigned to colouration categories (i.e., cryptic, aposematic, uniform metallic, or aposematic and metallic) by five independent observers. Those without an (*) were based on at least one voucher specimen. (*) indicates live images additionally available. Species in bold are those in which a majority opinion was not achieved by the independent observers, with ties broken by the senior author’s assignment that was made prior to surveying the observers.
Alltagsintegrierte Sprachförderung in Spielgruppen und Kindertageseinrichtungen in der Schweiz - Was gelingt, was kommt zu kurz?
Creators: name: Tovote, Katrin
name: Kappeler Suter, Silvana
name: Kannengieser, Simone
name: Ursprung, Antonia
Publisher: name: Hogrefe
Year: 2016
Subjects: Sprachförderung
alltagsintegrierte Sprachförderung
frühe Kindheit
Deutsch als Zweitsprache

description: Die vorliegende empirische Studie berichtet über die Prozess- und Orientierungsqualität von alltagsintegrierter Sprachförderung in Spielgruppen und Kindertageseinrichtungen in Basel-Stadt. Es wurden 16 Förderpersonen zu ihren Konzepten betreffend der Sprachförderung befragt und zehn Förderperson-Kind-Paare in Spielgruppen und Kindertageseinrichtungen gefilmt. Die Ergebnisse zeigen, dass die alltagsintegrierte Sprachförderung in Grundzügen umgesetzt wird, insofern die Sprachvermittlung nicht separiert und kommunikationsfern stattfindet. Sie zeigen aber auch, dass die zentralen Qualitätsfaktoren impliziter Sprachvermittlung Responsivität und Modellieren kindlicher Äußerungen im untersuchten Feld zu kurz kommen.
Additional file 1: of Combination of lymphovascular invasion and the AJCC TNM staging system improves prediction of prognosis in N0 stage gastric cancer: results from a high-volume institution
Creators: name: Lu, Jun
name: Dai, Yun
name: Xie, Jian-Wei
name: Wang, Jia-Bin
name: Lin, Jian-Xian
name: Chen, Qi-Yue
name: Cao, Long-Long
name: Lin, Mi
name: Tu, Ru-Hong
name: Zheng, Chao-Hui
name: Li, Ping
name: Huang, Chang-Ming
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Table S1. Lymphovascular invasion within each pT stage. (DOCX 16 kb)
International Day of Peace 2017: Best Inspirational Quotes
Creators: name: Berry, William
Publisher: name: figshare
Year: 2017
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160304 Mortality
subject: FOS: Sociology
subject: 169999 Studies in Human Society not elsewhere classified
subject: 160799 Social Work not elsewhere classified

description: The International Day of Peace is the day to transform fear into hope, hatred into love. This article contains thirty one powerful quotes for inspirations from the greatest personalities of the world. They are unique and most modern. We invite you to spread these words for peace across the world. This contains the words of Buddha, Gandhi, Mother Teresa, Amit Ray, Dalai Lama, John F. Kennedy, Thich Nhat Hanh, Bob Marley and many others.
Spandakārikā – Ācārya dr. Sthaneshwar Timalsina
Creators: name: Timalsina, Staneshwar
Publisher: name: Zenodo
Year: 2023
Subjects: Kali
mahadeva
agama
Mahakali
advaita vedanta
Kubjika
Shiva Sutra
Kashmir Shaivism
Kula
sarvamnaya
Saundaryalahari
krama
Camunda
Shiva
vimarsha-foundation
tantraloka
Spanda
Sadāśiva
Tripura Rahasya
vedanta
Abhinavagupta
saivadvaita
shakti
Guhyakālī
sthaneshwar timalsina
Durga
Bhairava
trika
Divine Mother
shambhava
Tantra
Devi Mahatmya
Tripurasundari
Sarvamnaya
timalsina
tripura
Mālinīvijayottaratantra
consciousness
Kaula
anava upaya
yantra
Īśāna
Vasugupta
shakta upāya
Chandi
Shaiva
sarvamnaya-oral-tradition-archive
Tantric philosophy
amnaya

description: Visit Vimarsha Foundation's website for more teachings, including FREE online courses offered by Śaivācārya Prof. Sthaneshwar Timalsina:
https://www.vimarshafoundation.org/courses

Join our Community on Facebook to discuss these topics and stay connected:
https://www.facebook.com/groups/vimarshafoundation/

Magh Navarātraṃ – January 2023
Excerpt from Spanda Talk Part 1 – https://www.youtube.com/watch?v=NFWxEY6WrBc&t=10s

Original YouTube video: https://www.youtube.com/watch?v=4NY-9zx8Qb4

This presentation is part of the Sarvāmnāya Oral Tradition Archive.
Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
Additional file 2: of Comparative proteomic analysis provides new insight into differential transmission of two begomoviruses by a whitefly
Creators: name: Zhao, Jing
name: Chi, Yao
name: Zhang, Xin-Jia
name: Lei, Teng
name: Wang, Xiao-Wei
name: Liu, Shu-Sheng
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Figure S1. CV distribution of replicates in each of the three combinations for comparison. X-axis is the deviation between the protein ratio of the repeated samples. Y-axis is the percentage of proteins at a certain angle with given levels of quantified proteins. CV value = SD/mean, the lower the value, the better the replication. (A) CV distributions in the comparison of TYLCV-infected vs. un-infected, (B) CV distributions in the comparison of PaLCuCNV-infected vs. un-infected, (C) CV distributions in the comparison of TYLCV-infected vs. PaLCuCNV-infected. (PDF 199 kb)
Kulturvielfalt in der Psychiatrie
Creators: name: Zemp, Sarah
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2016

description: Die Psychiatrische Klinik Münsterlingen ist im Zuge des Fachkräftemangels mit einem starken Mangel an Assistenzärztinnen und -ärzten konfrontiert und rekrutiert diese seit einiger Zeit vermehrt auch aus Drittstaaten. Mittels Hypothesentestung wurde untersucht, ob ein Zusammenhang zwischen der Kultur von Assistenzärztinnen und -ärzten und der Arbeits- und Patientenzufriedenheit besteht. Aus der Theorie gehen diese Zusammenhänge hervor. Die Analyse erfolgte anhand einer nicht-experimentellen Untersuchung mit 11 kulturell unter-schiedlichen Assistenzärztinnen und -ärzten sowie 103 Patientinnen und Patienten der Psychiatrischen Klinik Münsterlingen. Die Befragung wurde mit zwei verschiedenen Online-Fragebögen sowie einem Paper-Pencil-Fragebogen durchgeführt. Die Effekte zwischen einzelnen Kulturdimensionen und Patientenzufriedenheit sowie zwischen einzelnen Kulturdimensionen und Arbeitszufriedenheit konnten repliziert werden. Zudem besteht ein Zusammenhang zwischen Arbeits- und Patientenzufriedenheit.
title: Das ISAR-Screening in der Urologie: Ist ein geriatrisches Eingangsscreening bei der Charakterisierung hochbetagter Patienten hilfreich?
Creators: name: Wiedemann, A.
name: Püttmann, J.
name: Heppner, H.-J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Seit 2015 ist mit dem ISAR-Screening (Identification of seniors at risk, McCusker J, 1999) ein geriatrisches Eingangsscreening bei allen über 75jährigen Krankenhauspatienten in NRW vorgeschrieben. Unklar ist bisher, wie die so als „mit geriatrischem Handlungsbedarf“[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
PEMBERDAYAAN SISWA PEMANTAU JENTIK (WAMANTIK) SEBAGAI UPAYA PENCEGAHAN KEJADIAN LUAR BIASA (KLB) DEMAM BERDARAH DENGUE
Creators: name: Efendi, Ferry
name: Achmad Fachrizal
name: Windi WIjaya
name: Kamalia Hasanah
Publisher: name: figshare
Year: 2017
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences

description: Wamantik merupakan siswa pemantau jentik yang memiliki peran melakukan kegiatan surveilans, preventif serta promotif. Peran surveilans yang dilakukan meliputi identifikasi tempat sarang nyamuk, menghitung jumlah jentik dan jumlah kontainer. Peran preventif yang dilakukan adalah siswa dilatih untuk memahami pentingnya gerakan 3M dan mampu mengaplikasikan di lingkungan rumah khususnya dan lingkungan sekolah pada umumnya. Peran selanjutnya adalah peran promotif yang sesuai dengan tujuan pendidikan kesehatan dimana diharapkan siswa mampu melakukan promosi baik di keluarga, masyarakat dan sekolah akan bahaya serta pencegahan DBD. Fokus dari kegiatan ini adalah menanamkan sejak dini kepada para siswa mengenai bahaya DBD. Oleh karena itu pendidikan kesehatan mengenai DBD diberikan sebagai upaya awal meningkatkan pengetahuan mereka akan penyakit berbahaya ini. Kegiatan ini ditindaklanjuti dengan kegiatan pencarian jentik dan identifikasi kontainer sehingga dapat dihitung angka kontainer indeks untuk menentukan angka bebas jentik (ABJ). Siswa juga dilatih untuk melakukan gerakan 3M yang baik dan benar sebagai upaya efektif mencegah penyebaran nyamuk Aedes aegypti. Pada penelitian ini diukur tingkat pengetahuan siswa sebelum dan sesudah dilakukan pendidikan kesehatan. Hasil uji t berpasangan menunjukkan nilai p=0,000 sehingga didapatkan hubungan yang bermakna antara tingkat pengetahuan siswa sebelum dan sesudah diberikan pendidikan kesehatan. Angka bebas jentik yang semula 7% dapat ditingkatkan menjadi 96% pada akhir pelatihan. ABJ yang meningkat dapat memutus siklus hidup nyamuk sehingga kepadatan populasi serta regenerasi nyamuk akan berkurang. Dalam jangka panjang hal ini diharapkan mampu mencegah KLB DBD. Penerapan wamantik berbasis sekolah perlu diterapkan di Indonesia sebagai upaya mengurangi morbiditas dan mortalitas DBD.
NMR-based metabonomics of pre-clinical models of isoniazid and gentamicin toxicity
Creators: name: Cunningham, Katharine
Publisher: name: Imperial College London
Year: 2012

description: An individual's response to drug therapy is the result of complex interactions between environmental and genetic factors. The ability to characterise inter-individual variation in response to pharmaceutical intervention is of particular importance in a clinical setting, where variation in response can result in therapeutic failure or adverse effects in individuals or sub-populations of patients. Given the success of NMR-based techniques for metabolic profiling, this thesis focused on characterisation of the systems-wide endogenous metabolic response to isoniazid and gentamicin. Throughout this work, one-dimensional 1H and two-dimensional 1H NMR of biofluids and tissue was applied to generate metabolic profiles reflective of response to pharmaceutical intervention in the animal model, in conjunction with conventional clinical chemistry and histopathological assessment. Isoniazid is a widely prescribed anti-tubercular treatment that has toxic side effects: it is widely associated with both hepatotoxicity and peripheral neurotoxicity in the clinical setting. Here, a relationship was established between the post dose profile of drug metabolites and the severity of the adverse effect on the central nervous system. Further, the metabonomic approach resulted in the identification of pre-dose urinary markers of toxic outcome. The aminoglycoside antibiotic gentamicin is a known nephrotoxin. Clinical chemistry and histopathology identified clear differences in the degree of nephrotoxicity experienced by the rat relative to administration time. Complementary metabolic profiling techniques were then applied to the analysis of urine and kidney tissue, and identified clear metabolic differences in response to treatment time. A final study then explored whether co-administration of a statin (atorvastatin) could reduce gentamicin-induced nephrotoxicity in the rat. Conventional toxicity assessments indicated that co-administration of gentamicin and atorvastatin was non-toxic, while metabonomic analysis of urine and kidney tissue indicated that there were metabolic differences, likely linked to the antibiotic effect of gentamicin. This work highlights the potential for beneficial drug-drug interactions to decrease a drugs toxic effect, as well as the importance of considering administration time when developing treatment regimens.
The control of selectivity in partial oxidation of hydrocarbons
Creators: name: Aworinde, Samson Mayowa
Publisher: name: Apollo - University of Cambridge Repository
Year: 2018
Subjects: Selective oxidation
hydrocarbons
petrochemicals
selectivity
yield
process intensification
microstructured reactor
membrane reactor
reactor modelling
process optimisation
reaction kinetics

description: Cambridge Trust; ExxonMobil
Teamwork in the operating theatre : scientific principles of assessment and clinical applications
Creators: name: Hull, Louise Mary
Publisher: name: Imperial College London
Year: 2013

description: Hospitalised patients are most likely to suffer harm in the operating theatre. Non-technical and team skills have been identified, and are increasingly recognised, as critical to safety and efficiency in the operating theatre. Despite increasing awareness of the importance of these skills to patient safety, education, training and assessment is lacking. The overarching aim of this Thesis is to facilitate and accelerate the integration of these skills into the education, training, and assessment of operating theatre teams by addressing a number of challenges related to this endeavour. An introduction to patient safety and the core non-technical and team skills that underpin expertise and safety in the operating theatre is presented, providing the theoretical basis for this work (Chapters 1 & 2). A systematic review on the impact of non-technical skills on technical performance in surgery is presented (Chapter 3), underlining the need to integrate these skills into the education, training and assessment of operating theatre teams. The empirical work of this Thesis is then reported. An observational study exploring stress and teamwork in the operating theatre is presented (Chapter 4), increasing our understanding of the factors that facilitate and impede teamwork in the operating theatre. To ensure the robust assessment of teamwork in the operating theatre, the formal content validation and refinement of the Observational Teamwork Assessment for Surgery (OTAS) tool is reported (Chapter 5). This is followed by an observational study exploring team performance at specific operative stages, as well as in multiport versus single incision laparoscopic surgery (Chapter 6). Chapters 7-8 report the development of guidelines, based on expert consensus, to train faculty in the assessment of non-technical and teamwork skills, an essential feat if non-technical and team skills are to be successfully integrated into the training and assessment of operating theatre teams. Chapter 9 reports the development, piloting and evaluation of a programme, based on the findings of Chapters 7-8, to train faculty to assess teamwork in the operating theatre. Finally, Chapter 10 provides a general discussion of the work presented in this Thesis, reflecting on the findings and the wider evidence base. Implications for clinical practice, patient safety and future research are explored.