cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hoforsa Tedersoo 2024, gen. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Glomeromycota
Glomeromycetes
Hoforsales
Hoforsa

description: Hoforsa Tedersoo gen. nov.
Type species.
Hoforsa rebekkae Tedersoo.
Description.
Covers the monophyletic group in Hoforsaceae (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1100001, EUK 1107311 and EUK 1602325 (Suppl. material 3).
Notes.
Recognised based on eDNA sequences only. There are potentially about 20 species in Hoforsa based on ITS and LSU sequences, with examples including taxa represented by sequences EUK 1107311 (bog peat in Svartberget, Sweden, 64.24 ° N, 19.76 ° E) and AM 260926 (bog peat, Scotland) first isolated by Rebekka Artz (Artz et al. 2007). Most taxa are found from various soils, but the LSU sequence AB 982123 originates from an ectomycorrhizal root of Dipterocarpaceae (Lambir, Malaysia). The most common taxon at 99 % LSU sequence similarity (EUK 1602281) has been recorded from 31 localities in Estonia and Latvia. The genus has a global distribution and it occurs commonly in soil samples but rarely in roots.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Extraordinary Drift Wave in Space and Cylindrically Bounded Heavy Ion Plasmas
Creators: name: Saleem, Hamid
name: Saeed, Usman
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: It is pointed out that electrostatic and electromagnetic waves propagating in perpendicular direction to the density gradient $\nabla n_0=\hat{x} |\frac{dn_0}{dx}|$ and external magnetic field $\vec{B}_0=B_0 \hat{z}$ in hybrid frequency range $Ω_i \ll ω\ll Ω_e$ (where $Ω_j=\frac{eB_0}{m_j c}$ and $j=e,i$) have several applications in space and laboratory plasmas. The electron plasma waves are important for the future experiments on heavier ion plasmas as well as the results are applicable to the experiments performed to create pure pair ion fullerene plasmas. The electrostatic modes are shown to exist in upper F-region of terrestrial ionosphere and electromagnetic waves are applied to cylindrically bounded heavy ion plasmas.
Hoforsa rebekkae Tedersoo 2024, sp. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Glomeromycota
Glomeromycetes
Hoforsales
Hoforsaceae
Hoforsa
Hoforsa rebekkae

description: Hoforsa rebekkae Tedersoo sp. nov.
Diagnosis.
Separation from other species of Hoforsa based on the ITS region (ITS 2 positions 108–127 ggratcycccgaggtgtgaaac; one mismatch allowed) and LSU (positions 546–565 ctcctggtgctctcacccgt; no mismatch allowed) as indicated in Fig. 4.
Type.
Soil eDNA sample: TUE 128830 (holotype); eDNA sequence EUK 1100001 (lectotype); Pinus sylvestris forest near Hofors, Sweden (60.49 ° N, 16.30 ° E).
Description.
Other sequences: EUK 1104560 (type locality); OU 004104 (San Francisco, Ecuador, root sample); and KP 889387 and KP 889486 (both coniferous forest soil in British Columbia, Canada).
Etymology.
Hofors (Swedish) refers to type locality; and Rebekka (Scotch) refers to the first name Rebekka Artz who was the first to collect materials from this genus.
Notes.
Found from three sites across three continents, with ITS sequences differing up to 3.5 % and LSU sequences up to 0.5 %.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Additional file 2: of The Fabrication of Nanoimprinted P3HT Nanograting by Patterned ETFE Mold at Room Temperature and Its Application for Solar Cell
Creators: name: Guangzhu Ding
name: Kaixuan Wang
name: Xiaohui Li
name: Chen, Qing
name: Zhijun Hu
name: Jieping Liu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: One-dimensional GIWAXD curves in the q xy direction. Curves are integrated from Fig. 4a, b, c. Parallel and vertical are referred as measurements performed with nanograting line direction parallel and perpendicular to the direction of incident X-rays. It indicates that the (010) reflection signals of samples is present indeed in the q xy direction, which can be indicated by the one-dimensional integrated curve stem from the Fig. 4a, b, c. The peaks at q = 16.8 nm−1 refer to the (010) plane reflections of P3HT crystal and can be investigated for the three samples. (DOC 45 kb)
An elementary heuristic for Hardy-Littlewood extended Goldbach's conjecture
Creators: name: Táfula, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 11P32

description: The goal of this paper is to describe an elementary combinatorial heuristic that predicts Hardy and Littlewood's extended Goldbach's conjecture. We examine common features of other heuristics in additive prime number theory, such as Cramér's model and density-type arguments, both of which our heuristic draws from. Apart from the prime number theorem, our argument is entirely elementary, in the sense of not involving complex analysis. The idea is to model sums of two primes by a hypergeometric probability distribution, and then draw heuristic conclusions from its concentration behavior, which follows from Hoeffding-type bounds.
description: 13 pages, 3 figures. The old version of this article ([v1], [v2]) has been expanded and split into two separate papers: arXiv:1807.10200 and the present one. From [v3], [v4] to this version: grammar was corrected, references were added, and figures were adjusted. For the scripts used to generate the figures, see https://github.com/tafula/hl_ext_gb_conj
Kahvenales Tedersoo 2024, ord. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Kahvenales

description: Kahvenales Tedersoo ord. nov.
Type family.
Kahvenaceae Tedersoo.
Description.
Covers the monophyletic group in Endogonomycetes (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1634339 and EUK 1630771 (Suppl. material 3).
Notes.
Recognised based on eDNA sequences only. Currently includes Kahvenaceae.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Kishidaria Dubatolov 2004
Creators: name: Singh, Navneet
name: Joshi, Rahul
name: Kirti, Jagbir Singh
name: Bisht, Santosh Singh
name: Param, Harsimranjeet Singh
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Kishidaria

description: Genus Kishidaria Dubatolov, 2004: 73
Type species: Calpenia khasiana Moore, 1878
description: Published as part of Singh, Navneet, Joshi, Rahul, Kirti, Jagbir Singh, Bisht, Santosh Singh & Param, Harsimranjeet Singh, 2021, A catalogue of Indian Arctiinae (Erebidae, Lepidoptera), pp. 1-118 in Zootaxa 5058 (1) on page 24, DOI: 10.11646/zootaxa.5058.1.1, http://zenodo.org/record/5602576
MOESM1 of Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs
Creators: name: Tessitore, Marion
name: Sottini, Alessandra
name: Roccaro, Aldo
name: Ghidini, Claudia
name: Bernardi, Simona
name: Martellosio, Giovanni
name: Serana, Federico
name: Imberti, Luisa
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Additional file 1: Figure S1. dPCR plots for TREC and KREC quantification. A) Representative dPCR plots of TREC and KREC quantification in HeLa cells. The cell line is used to establish the threshold values, which were set up at 5000 for FAM (TRECs) fluorescence and 4000 for VIC (KRECs) fluorescence. B) Representative dPCR plots of TREC and KREC quantification in a positive sample showing that the threshold values allow a precise separation between positive and negative dot plots. The data points in the plots are color-coded: FAM (blue), VIC (red), FAM plus VIC (green), undetermined (grey) and not amplified (yellow).
Additional file 1: Figure S1. of Synthesis of Si-Sb-ZnO Composites as High-Performance Anodes for Lithium-ion Batteries
Creators: name: Yongliang Li
name: Huang, Liang
name: Peixin Zhang
name: Xiangzhong Ren
name: Libo Deng
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Plasma Physics

description: Cycling performance of ZnO, Si-Sb, Si-Sb-(ZnO)0.3 anode materials.
MOESM2 of Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs
Creators: name: Tessitore, Marion
name: Sottini, Alessandra
name: Roccaro, Aldo
name: Ghidini, Claudia
name: Bernardi, Simona
name: Martellosio, Giovanni
name: Serana, Federico
name: Imberti, Luisa
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Additional file 2: Table S1. Intra-assay and inter-assay variation for dPCR.
Kahvenaceae Tedersoo 2024, fam. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Kahvenales
Kahvenaceae

description: Kahvenaceae Tedersoo fam. nov.
Type genus.
Kahvena Tedersoo.
Description.
Covers the monophyletic group in Kahvenales (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1634339 and EUK 1630771 (Suppl. material 3).
Notes.
Recognised based on eDNA sequences only. Currently includes Kahvena.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Additional file 1: Table S1. of Exposure to household furry pets influences the gut microbiota of infant at 3â  4Â months following various birth scenarios
Creators: name: Tun, Hein
name: Konya, Theodore
name: Takaro, Tim
name: Brook, Jeffrey
name: Chari, Radha
name: Field, Catherine
name: Guttman, David
name: Becker, Allan
name: Piush Mandhane
name: Turvey, Stuart
name: Padmaja Subbarao
name: Sears, Malcolm
name: Scott, James
name: Kozyrskyj, Anita
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: PERMANOVA analysis used to evaluate microbial community differences of infant gut at 3â  4Â months due to pet exposures following different birth scenarios. (DOCX 35 kb)
Meertens number and its variations
Creators: name: Wu, Chai Wah
Publisher: name: arXiv
Year: 2016
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11A05, 11A41

description: In 1998, Bird introduced Meertens numbers as numbers that are invariant under a map similar to the Godel encoding. In base 10, the only known Meertens number is 81312000. We look at some properties of Meertens numbers and consider variations of this concept. In particular, we consider variations where there is a finite time algorithm to decide whether such numbers exist.
Additional file 2: of Co-producing public involvement training with members of the public and research organisations in the East Midlands: creating, delivering and evaluating the lay assessor training programme
Creators: name: Horobin, Adele
name: Brown, George
name: Higton, Fred
name: Vanhegan, Stevie
name: Wragg, Andrew
name: Wray, Paula
name: Dawn-Marie Walker
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Lay assessors in research. Role summary for a lay assessor. (PDF 604 kb)
Kahvena Tedersoo 2024, gen. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Tracheophyta
Magnoliopsida
Kahvenales
Kahvenaceae
Kahvena

description: Kahvena Tedersoo gen. nov.
Type species.
Kahvena rebeccae Tedersoo.
Description.
Covers the monophyletic group in Kahvenaceae (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1634339 and EUK 1630771 (Suppl. material 3).
Notes.
Recognised based on eDNA sequences only. Based on ITS sequences, Kahvena is comprised of two species; the other represented by sequences EUK 1630771 (GSMc plot G 4185, Picea - Pinus forest soil in Ristipalo, Estonia, 58.10241 ° N, 27.47874 ° E) and ON 963629 (Pinus sylvestris forest soil, Lithuania).
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Male perspectives on intimate partner violence: A qualitative analysis from South Africa
Creators: name: Pellowski J
name: Hatcher A
name: Pelowich K.A.
name: Christofides N
name: Akibu T.
name: Hampanda K
name: Rebombo D
Publisher: name: Public Library of Science
Year: 2024

description: Background Intimate partner violence (IPV) affects one in four women globally and is more commonly enacted by men than women. Rates of IPV in South Africa exceed the global average. Exploring the background and context regarding why men use violence can help future efforts to prevent IPV. Methods We explored adult men’s perspectives of IPV, livelihoods, alcohol use, gender beliefs, and childhood exposure to abuse through a secondary analysis of qualitative interviews that were conducted in South Africa. The setting was a peri-urban township characterized by high unemployment, immigration from rural areas, and low service provision. We utilized thematic qualitative analysis that was guided by the social ecological framework. Results Of 30 participants, 20 were residents in the neighborhood, 7 were trained community members, and 3 were program staff. Men reported consumption of alcohol and lack of employment as being triggers for IPV and community violence in general. Multiple participants recounted childhood exposure to abuse. These themes, in addition to culturally prescribed gender norms and constructs of manhood, seemed to influence the use of violence. Conclusion Interventions aimed at reducing IPV should consider the cultural and social impact on men’s use of IPV in low-resource, high-IPV prevalence settings, such as peri-urban South Africa. This work highlights the persistent need for the implementation of effective primary prevention strategies that address contextual and economic factors in an effort to reduce IPV that is primarily utilized by men directed at women.
Additional file 1: of Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin
Creators: name: Radbruch, Moritz
name: Pischon, Hannah
name: Ostrowski, Anja
name: Volz, Pierre
name: Brodwolf, Robert
name: Neumann, Falko
name: Unbehauen, Michael
name: Kleuser, Burkhard
name: Haag, Rainer
name: Ma, Nan
name: Alexiev, Ulrike
name: Mundhenk, Lars
name: Gruber, Achim
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Detailed Methods. (DOCX 40.1 kb)
Kahvena rebeccae Tedersoo 2024, sp. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Tracheophyta
Magnoliopsida
Kahvenales
Kahvenaceae
Kahvena
Kahvena rebeccae

description: Kahvena rebeccae Tedersoo sp. nov.
Diagnosis.
Separation from other species of Kahvena based on the ITS region (ITS 2 positions 200–218 cattcgcaggaatagccag; one mismatch allowed) and from other species of Endogonomycetes based on LSU (positions 653–683 acgcaagctccagatcgaatctccgggctaa; one mismatch allowed) as indicated in Fig. 5.
Type.
Soil eDNA sample TUE 100738 (holotype); eDNA sequence EUK 1634339 (lectotype); GSMc plot G 4196, Populus - Picea - Pinus forest (soil sample TUE 000738) in Kahvena, Estonia (58.27991 ° N, 25.23165 ° E).
Description.
Other sequences: EUK 1635883 – EUK 1635886 (type locality); EUK 1631811 (GSMc plot G 2767, mixed woodland soil at Mäebe, Estonia, 58.30937 ° N, 22.07618 ° E); KF 618358 (Picea mariana forest soil, AK, USA); MT 596306 (Tobiotsuka Kofun, Japan, 34.6355 ° N, 133.6814 ° E); KU 062529 (unknown source); and KF 565426 (Duke Forest, NC, USA, 35.97 ° N, - 79.09 ° E), isolated by Rebecca C. Mueller (Mueller et al. 2014).
Etymology.
Kahvena (Estonian) refers to type locality; and Rebecca (English) refers to the first name of Rebecca C. Mueller, who collected the first materials belonging to this genus and the type species.
Notes.
Found from temperate and subarctic forests in Europe, Asia and North America, with ITS and LSU sequences differing up to 4 % (excluding a 29 - base deletion in EUK 1631811 and KU 062529) and 1.5 %, respectively. Considered as a single species because of high intraspecific variation amongst common sequence variants in the type locality (2 % in ITS and 1 % in LSU, representing both indels and substitutions).
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
MOESM1 of Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs
Creators: name: Tessitore, Marion
name: Sottini, Alessandra
name: Roccaro, Aldo
name: Ghidini, Claudia
name: Bernardi, Simona
name: Martellosio, Giovanni
name: Serana, Federico
name: Imberti, Luisa
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 1: Figure S1. dPCR plots for TREC and KREC quantification. A) Representative dPCR plots of TREC and KREC quantification in HeLa cells. The cell line is used to establish the threshold values, which were set up at 5000 for FAM (TRECs) fluorescence and 4000 for VIC (KRECs) fluorescence. B) Representative dPCR plots of TREC and KREC quantification in a positive sample showing that the threshold values allow a precise separation between positive and negative dot plots. The data points in the plots are color-coded: FAM (blue), VIC (red), FAM plus VIC (green), undetermined (grey) and not amplified (yellow).
Additional file 1: of Technology roadmap for smart electric vehicle-to-grid (V2G) of residential chargers
Creators: name: Tugrul Daim
name: Xiaowen Wang
name: Cowan, Kelly
name: Shott, Tom
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: A. The marketing driver roadmapping in details. B. The product/feature roadmapping in details. C. The technology roadmapping in details. D. The resource roadmapping in details. (DOCX 263 kb)
Optimizing generalized kernels of polygons
Creators: name: Martinez-Moraian, Alejandra
name: Orden, David
name: Palios, Leonidas
name: Seara, Carlos
name: Żyliński, Paweł
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computational Geometry (cs.CG)
subject: FOS: Computer and information sciences

description: Let $\mathcal{O}$ be a set of $k$ orientations in the plane, and let $P$ be a simple polygon in the plane. Given two points $p,q$ inside $P$, we say that $p$ $\mathcal{O}$-\emph{sees} $q$ if there is an $\mathcal{O}$-\emph{staircase} contained in $P$ that connects $p$ and~$q$. The \emph{$\mathcal{O}$-Kernel} of the polygon $P$, denoted by $\mathcal{O}$-$\rm kernel(P)$, is the subset of points of $P$ which $\mathcal{O}$-see all the other points in $P$. This work initiates the study of the computation and maintenance of $\mathcal{O}$-$\rm kernel(P)$ as we rotate the set $\mathcal{O}$ by an angle $θ$, denoted by $\mathcal{O}$-$\rm kernel_θ(P)$. In particular, we consider the case when the set $\mathcal{O}$ is formed by either one or two orthogonal orientations, $\mathcal{O}=\{0^\circ\}$ or $\mathcal{O}=\{0^\circ,90^\circ\}$. For these cases and $P$ being a simple polygon, we design efficient algorithms for computing the $\mathcal{O}$-$\rm kernel_θ(P)$ while $θ$ varies in $[-\fracπ{2},\fracπ{2})$, obtaining: (i)~the intervals of angle~$θ$ where $\mathcal{O}$-$\rm kernel_θ(P)$ is not empty, (ii)~a value of angle~$θ$ where $\mathcal{O}$-$\rm kernel_θ(P)$ optimizes area or perimeter. Further, we show how the algorithms can be improved when $P$ is a simple orthogonal polygon. In addition, our results are extended to the case of a set $\mathcal{O}=\{α_1,\dots,α_k\}$.
description: 34 pages, 16 figures, accepted version
Managing potential adverse events during treatment with enfortumab vedotin + pembrolizumab in patients with advanced urothelial cancer
Creators: name: Eitman, Cheryl
name: McCoy, Asia
name: Milowsky, Matthew I.
name: Rembisz, Jennifer
name: Bowman, I. Alex
name: Ahmad, Hiba
name: Brower, Blaine
Publisher: name: Frontiers
Year: 2024

description: Cisplatin-based chemotherapy has been the standard of care for patients with locally advanced or metastatic urothelial cancer (la/mUC). Enfortumab vedotin, an antibody-drug conjugate directed to Nectin-4, and pembrolizumab, an immune checkpoint inhibitor, are two therapies that have individually provided a survival benefit in patients with la/mUC. The combination regimen of enfortumab vedotin plus pembrolizumab was evaluated in EV-302 (KEYNOTE-A39; NCT0422385), a phase 3 study that showed statistically significant and clinically meaningful improvement in overall survival, progression-free survival, and a key secondary endpoint of overall response rate versus chemotherapy. Based on these results and those from the EV-103 (KEYNOTE-869; NCT03288545) Dose Escalation cohort, Cohort A, and Cohort K, enfortumab vedotin plus pembrolizumab was granted approval from the US Food and Drug Administration for the treatment of adults with la/mUC. While guidelines and recommendations for the management of adverse events (AEs) have been developed for immune checkpoint inhibitor monotherapy and enfortumab vedotin monotherapy, additional guidance is needed for managing AEs that occur with enfortumab vedotin plus pembrolizumab. As monotherapies, enfortumab vedotin and pembrolizumab are both associated with some of the AEs observed with the combination, such as skin reactions, pneumonitis, and diarrhea, which may confound the attribution of the AE to a specific agent and thereby complicate clinical management. In this manuscript, we aim to provide recommendations for best practice for patient care and the management of AEs of clinical interest for patients with la/mUC receiving enfortumab vedotin plus pembrolizumab, including skin reactions, peripheral neuropathy, hyperglycemia, and pneumonitis. These recommendations were developed based on published guidelines, expert opinions, and the clinical experience of the authors, which include oncologist, advanced practice provider, nursing, and pharmacy perspectives. In addition, guidance on patient education and communication is provided. With vigilant monitoring, early detection, and prompt intervention of treatment-emergent AEs based on recommended approaches described herein, it is the authors’ experience that most AEs can be managed with supportive therapy and dose modification/interruptions, allowing patients to continue treatment.
'Computer-Aided Ethnography' (CAE)
Creators: name: Nabben, Kelsie
name: Zargham, Michael
name: Rennie, Ellie
Publisher: name: Zenodo
Year: 2023

description: This post discusses a concept that builds on existing ethnographic approaches, that we call ‘Computer-Aided Ethnography’ (CAE). Our ethnographic research on Web3 uses some of the same software tools that define ‘Web3’ (referring to communities that participate in the practice of decentralized technologies, such as public blockchains), as digitally native communities. In this post, we discuss why we do this, as well as how it builds on existing practices of ethnography to enable participation by a community being researched on their own terms. We find that CAE offers a unique methodological approach that enables research participants to contribute to both the social and technical dimensions of the research according to their preferences, creating fertile ground for ethnographic interactions and co-constitution in the field of Web3. It remains to be researched how CAE methods may be adapted and applied in other digitally native field sites.
Macropodus La Cepede 1801
Creators: name: Chen, I-Shiung
name: Chiu, Yuh-Wen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Osphronemidae
Macropodus

description: Macropodus La Cepède, 1801
Macropodus La Cepède, 1801: 416
(type species: Macropodus viridiauratus La Cepède, 1801: 416, 417, by monotypy). Gender masculine.
description: Published as part of Chen, I-Shiung & Chiu, Yuh-Wen, 2024, A new species of Macropodus (Teleotsei: Osphronemidae) from Fujian Province, southern China, pp. 328-332 in Zootaxa 5550 (1) on page 329, DOI: 10.11646/zootaxa.5550.1.33, http://zenodo.org/record/14389374
Kelottijaerviales Tedersoo 2024, ord. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Kelottijaerviales

description: Kelottijaerviales Tedersoo ord. nov.
Type family.
Kelottijaerviaceae Tedersoo.
Description.
Covers the monophyletic group in Endogonomycetes (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1202520 and EUK 1633699 (Suppl. material 3).
Notes.
Recognised based on eDNA sequences only. Currently includes Kelottijaerviaceae.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Additional file 1: Table S1. of Exposure to household furry pets influences the gut microbiota of infants at 3â  4Â months following various birth scenarios
Creators: name: Tun, Hein
name: Konya, Theodore
name: Takaro, Tim
name: Brook, Jeffrey
name: Chari, Radha
name: Field, Catherine
name: Guttman, David
name: Becker, Allan
name: Piush Mandhane
name: Turvey, Stuart
name: Padmaja Subbarao
name: Sears, Malcolm
name: Scott, James
name: Kozyrskyj, Anita
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: PERMANOVA analysis used to evaluate microbial community differences of infant gut at 3â  4Â months due to pet exposures following different birth scenarios. (DOCX 35 kb)
An extension of the Erdős-Tetali theorem
Creators: name: Táfula, Christian
Publisher: name: arXiv
Year: 2018
Subjects: subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11B13, 11B34 (Primary), 05D40 (Secondary)

description: Given a sequence $\mathscr{A}=\{a_0 0, \] then there must exist $\mathscr{A}\subseteq\mathbb{N}$ with $|\mathscr{A}\cap [0,x]|=Θ(f(x))$ for which $r_{\mathscr{A},h+\ell}(n) = Θ(f(n)^{h+\ell}/n)$ for all $\ell \geq 0$. Furthermore, for $h=2$ this condition can be weakened to $x^{1/2}\log(x)^{1/2} \ll f(x) \ll x$. The proof is somewhat technical and the methods rely on ideas from regular variation theory, which are presented in an appendix with a view towards the general theory of additive bases. We also mention an application of these ideas to Schnirelmann's method.
description: 41 pages
Maximum rectilinear convex subsets
Creators: name: González-Aguilar, Hernán
name: Orden, David
name: Pérez-Lantero, Pablo
name: Rappaport, David
name: Seara, Carlos
name: Tejel, Javier
name: Urrutia, Jorge
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computational Geometry (cs.CG)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences

description: Let $P$ be a set of $n$ points in the plane. We consider a variation of the classical Erdős-Szekeres problem, presenting efficient algorithms with $O(n^3)$ running time and $O(n^2)$ space complexity that compute: (1) A subset $S$ of $P$ such that the boundary of the rectilinear convex hull of $S$ has the maximum number of points from $P$, (2) a subset $S$ of $P$ such that the boundary of the rectilinear convex hull of $S$ has the maximum number of points from $P$ and its interior contains no element of $P$, (3) a subset $S$ of $P$ such that the rectilinear convex hull of $S$ has maximum area and its interior contains no element of $P$, and (4) when each point of $P$ is assigned a weight, positive or negative, a subset $S$ of $P$ that maximizes the total weight of the points in the rectilinear convex hull of $S$.
 We also revisit the problems of computing a maximum-area orthoconvex polygon and computing a maximum-area staircase polygon, amidst a point set in a rectangular domain. We obtain new and simpler algorithms to solve both problems with the same complexity as in the state of the art.
description: 27 pages, 15 figures, accepted version
Additional file 4: of PubChem structureâ  activity relationship (SAR) clusters
Creators: name: Sunghwan Kim
name: Lianyi Han
name: Yu, Bo
name: HĂ¤Hnke, Volker
name: Bolton, Evan
name: Bryant, Stephen
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: (supplementary_data.pdf): contains Figures S1, S2, and S3.
Kishidaria khasiana
Creators: name: Singh, Navneet
name: Joshi, Rahul
name: Kirti, Jagbir Singh
name: Bisht, Santosh Singh
name: Param, Harsimranjeet Singh
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Kishidaria
Kishidaria khasiana

description: 54. Kishidaria khasiana (Moore, 1878): 5
Type locality: Khasia hills [India: Meghalaya]
Distribution: Eastern India [North East India] (Dubatolov 2010).
description: Published as part of Singh, Navneet, Joshi, Rahul, Kirti, Jagbir Singh, Bisht, Santosh Singh & Param, Harsimranjeet Singh, 2021, A catalogue of Indian Arctiinae (Erebidae, Lepidoptera), pp. 1-118 in Zootaxa 5058 (1) on page 24, DOI: 10.11646/zootaxa.5058.1.1, http://zenodo.org/record/5602576
Kelottijaerviaceae Tedersoo 2024, fam. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Kelottijaerviales
Kelottijaerviaceae

description: Kelottijaerviaceae Tedersoo fam. nov.
Type genus.
Kelottijaervia Tedersoo.
Description.
Covers the monophyletic group in Kelottijaerviales (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1202520 and EUK 1633699 (Suppl. material 3).
Notes.
Recognised based on eDNA sequences only. Currently includes Kelottijaervia.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
MOESM2 of Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism
Creators: name: Zhang, Li-Xiang
name: Zhang, Wei-Yan
name: Wang, Chen
name: Liu, Jin-Tao
name: Xian-Cun Deng
name: Liu, Xu-Ping
name: Fan, Li
name: Wen-Song Tan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: Additional file 2: Figure S1. The time profile of cell growth. The effects of total amount (asparagine and glutamine) (A) and ratio (asparagine/glutamine) (B) on cell growth were shown.
Kelottijaervia Tedersoo 2024, gen. nov.
Creators: name: Tedersoo, Leho
name: Magurno, Franco
name: Alkahtani, Saad
name: Mikryukov, Vladimir
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Fungi
Tracheophyta
Magnoliopsida
Kelottijaerviales
Kelottijaerviaceae
Kelottijaervia

description: Kelottijaervia Tedersoo gen. nov.
Type species.
Kelottijaervia shannonae Tedersoo.
Description.
Covers the monophyletic group in Kelottijaerviaceae (Fig. 2). Phylogenetically delimited as the least inclusive clade covering sequence accessions EUK 1202520 and EUK 1633699 (Suppl. material 3).
Notes.
Based on ITS and LSU sequences, Kelottijaervia is comprised of about five species that are represented by sequences EUK 1603128 (GSMc plot G 2755 X, Pinus sylvestris forest soil, Liiva-Putla, Estonia, 58.38859 ° N, 22.65545 ° E); EUK 0302816 (plot G 5403, mixed coniferous forest in Kõrveküla, Estonia, 58.43789 ° N, 26.75099 ° E); EUK 1104755 (Pinus sylvestris forest soil near Hofors, Sweden, 60.49 ° N, 16.30 ° E); and KP 889573 (coniferous forest soil in British Columbia, Canada). The genus seems to prefer acidic coniferous forest habitats.
description: Published as part of Tedersoo, Leho, Magurno, Franco, Alkahtani, Saad & Mikryukov, Vladimir, 2024, Phylogenetic classification of arbuscular mycorrhizal fungi: new species and higher-ranking taxa in Glomeromycota and Mucoromycota (class Endogonomycetes), pp. 249-271 in MycoKeys 107 on pages 249-271, DOI: 10.3897/mycokeys.107.125549
Additional fie 3: Table S2.
Creators: name: Freeman, Jamie
name: Smith, David
name: Latinkic, Branko
name: Ewan, Ken
name: Samuel, Lee
name: Zollo, Massimo
name: Marino, Natascia
name: Tyas, Lorraine
name: Jones, Nick
name: Dale, Trevor
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Summary of Xenopus data. (PDF 24 kb)
Aenigmaraphidophora AZAR & MAALOUF & NEL 2022, gen. nov.
Creators: name: AZAR, DANY
name: MAALOUF, RAMY
name: NEL, ANDRÉ
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Aenigmaraphidophora

description: Genus Aenigmaraphidophora gen. nov.
urn:lsid:zoobank.org:act: 7EFAE62D-2D6E-4DB7- B2EC-F6C6579455A5
Type species. Aenigmaraphidophora mouniri sp. nov.
Etymology. Named after the Latin ‘aenigma’ for its enigmatic family position, and the genus name Raphidophora, Gender feminine.
Diagnosis. Very long maxillary palps, longer than fore legs; upper margin of first segment of hind tarsi without any spines; fore coxa with a lateral tubercle; mid femora with one inner and one outer relatively large movable apical spines; male subgenital plate with styles; longest apical spur of hind tibiae slightly shorter than first and second segments of hind tarsi combined; no process on dorsal surface of abdominal tergites; epiproct without process; hind 2 nd and 3 rd tarsomeres with a widened pulvillus.
description: Published as part of AZAR, DANY, MAALOUF, RAMY & NEL, ANDRÉ, 2022, An enigmatic Tettigoniidea from the Lower Cretaceous amber of Bqaatouta, Lebanon (Orthoptera, Ensifera), pp. 233-239 in Palaeoentomology 5 (3) on page 234, DOI: 10.11646/palaeoentomology.5.3.5, http://zenodo.org/record/6820833
Aenigmaraphidophora mouniri AZAR & MAALOUF & NEL 2022, sp. nov.
Creators: name: AZAR, DANY
name: MAALOUF, RAMY
name: NEL, ANDRÉ
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Aenigmaraphidophora
Aenigmaraphidophora mouniri

description: Aenigmaraphidophora mouniri sp. nov.
(Figs 1–3) urn:lsid:zoobank.org:act: DF023468-4A2E-45B3-8D0B- 13826D4F2F13
Material. Holotype of Aenigmaraphidophora mouniri gen. et sp. nov. (a nearly complete fossil, either a larva or a male), specimen number BKT-3A, Maalouf Collection, is stored at the Natural History Museum of the Lebanese University, Faculty of Sciences II, Fanar, Lebanon.
Etymology. Named after Dr Mounir Maalouf, father of RM and discoverer of the amber site and studied material.
Diagnosis. As for the genus, vide supra.
Type locality and horizon. Bqaatouta amber outcrop (33°58′0″N, 35°47′13″E, elev. 1,177 m), Caza (= District) Kesserouan, Central Lebanon, lower Barremian.
Description. Body 2.61 mm long (from head tip to abdomen); head 1.43 mm long; clypeus divided into an ante- and a postclypeus; antenna with 55 segments, 8.46 mm long; maxillary palp 2.15 mm long; apical sensory zone of maxillary palp elongate (Fig. 2B), much longer than palp apical width; thorax 0.97 mm long, 0.92 mm high; four tarsomeres on all legs; fore leg with tibia 0.95 mm long, tarsus 0.4 mm long, distal articulation zone of fore coxa displaced laterally; tympan present on fore tibia (Fig. 2C); mid femur 2.53 long, with one inner and one outer relatively large movable apical spines, tibia 0.91 mm long, tarsus 0.55 mm long; hind femur 2.06 mm long, with outer side without any chevron ridges, tibia 1.76 mm long, with longest apical spur slightly shorter than first and second segments of hind tarsi combined, hind tarsi laterally compressed, 1 st tarsomere with one flat pulvillus, 2 nd and 3 rd tarsomeres with a widened pulvilllus; abdomen 1.25 mm long, 1.3 mm high; no femoro-abdominal stridulatory apparatus observable; abdominal tergites without obvious process on dorsal surface; epiproct without posterior process; cerci 0.95 mm long, straight, bearing very long setae, but without any bulbous-like sensillae; subgenital plate with styles (Fig. 3C).
description: Published as part of AZAR, DANY, MAALOUF, RAMY & NEL, ANDRÉ, 2022, An enigmatic Tettigoniidea from the Lower Cretaceous amber of Bqaatouta, Lebanon (Orthoptera, Ensifera), pp. 233-239 in Palaeoentomology 5 (3) on page 234, DOI: 10.11646/palaeoentomology.5.3.5, http://zenodo.org/record/6820833
Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and Alzheimer’s Disease
Creators: name: Levine S.R.
name: Kapogiannis D
name: Witek M.A
name: Ford J.M
name: Merenstein D
name: Diaz M.M.
name: Pulliam L.
name: Song S
name: McCafferty E
name: Glesby M.J
name: Lake J.E.
name: McKay H.
name: Tang N.
name: Soper S.A
name: Hu M
name: Fischl M.A.
name: French A.
name: Ofotokun I.
name: Margolick J.B.
name: Sun B.
name: Martinson J.
name: Li W.
name: Tien P.C
name: Kim E.-Y.
name: Freasier H
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2024

description: Long COVID (LongC) is associated with a myriad of symptoms including cognitive impairment. We reported at the beginning of the COVID-19 pandemic that neuronal-enriched or L1CAM+ extracellular vesicles (nEVs) from people with LongC contained proteins associated with Alzheimer’s disease (AD). Since that time, a subset of people with prior COVID infection continue to report neurological problems more than three months after infection. Blood markers to better characterize LongC are elusive. To further identify neuronal proteins associated with LongC, we maximized the number of nEVs isolated from plasma by developing a hybrid EV Microfluidic Affinity Purification (EV-MAP) technique. We isolated nEVs from people with LongC and neurological complaints, AD, and HIV infection with mild cognitive impairment. Using the OLINK platform that assesses 384 neurological proteins, we identified 11 significant proteins increased in LongC and 2 decreased (BST1, GGT1). Fourteen proteins were increased in AD and forty proteins associated with HIV cognitive impairment were elevated with one decreased (IVD). One common protein (BST1) was decreased in LongC and increased in HIV. Six proteins (MIF, ENO1, MESD, NUDT5, TNFSF14 and FYB1) were expressed in both LongC and AD and no proteins were common to HIV and AD. This study begins to identify differences and similarities in the neuronal response to LongC versus AD and HIV infection.
Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders
Creators: name: Lopez, Alejandro G.
name: Morrow, A. Leslie
name: Boero, Giorgia
name: Chéry, Samantha Lucenell
name: Balan, Irina
name: McFarland, Minna H.
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2024

description: Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies highlight their therapeutic potential, particularly in conditions like postpartum depression (PPD), where the FDA-approved compound brexanolone, an intravenous formulation of allopregnanolone, effectively suppresses TLR-mediated inflammatory pathways, predicting symptom improvement. Additionally, pregnane neurosteroids exhibit trophic and anti-inflammatory properties, stimulating the production of vital trophic proteins and anti-inflammatory factors. Androstane neuroactive steroids, including estrogens and androgens, along with dehydroepiandrosterone (DHEA), display diverse effects on TLR expression and activation. Notably, androstenediol (ADIOL), an androstane neurosteroid, emerges as a potent anti-inflammatory agent, promising for therapeutic interventions. The dysregulation of immune responses via TLR signaling alongside reduced levels of endogenous neurosteroids significantly contributes to symptom severity across various neuropsychiatric disorders. Neuroactive steroids, such as allopregnanolone, demonstrate efficacy in alleviating symptoms of various neuropsychiatric disorders and modulating neuroimmune responses, offering potential intervention avenues. This review emphasizes the significant therapeutic potential of neuroactive steroids in modulating TLR signaling pathways, particularly in addressing inflammatory processes associated with neuropsychiatric disorders. It advances our understanding of the complex interplay between neuroactive steroids and immune responses, paving the way for personalized treatment strategies tailored to individual needs and providing insights for future research aimed at unraveling the intricacies of neuropsychiatric disorders.