cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
Creators: name: Renström, Frida
name: Li, Yanping
name: Kanoni, Stavroula
name: Laaksonen, Maarit A.
name: Xu, Min
name: Lin, Xiaochen
name: Qi, Qibin
name: Liu, Zhonghua
name: Ängquist, Lars H.
name: Kilpeläinen, Tuomas O.
name: Chen, Peng
name: Jääskeläinen, Tiina
name: Lee, Nanette R.
name: Boer, Jolanda M.A.
name: Huang, Jinyan
name: Holloway, John W.
name: Tanaka, Toshiko
name: Ahluwalia, Tarunveer Singh
name: Daimon, Makoto
name: Chu, Audrey Y.
name: Kim, Yu-Mi
name: Sonestedt, Emily
name: Downer, Mary K.
name: Houston, Denise K.
name: Gao, Yu-Tang
name: Perola, Markus
name: Eriksson, Johan
name: Friedlander, Yechiel
name: Asif Ali, Muhammad
name: Sluijs, Ivonne
name: Smith, Caren E.
name: Heppe, Denise H.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m2, P = 1.9 × 10−105), and all participants (0.30 [0.30, 0.35] kg/m2, P = 3.6 × 10−107). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10−16), and relative weak associations with lower total energy intake (−6.4 [−10.1, −2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (−0.07 [−0.11, −0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10−9) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
Creators: name: Shaikh Solaiman, Nadeen
Publisher: name: University of Westminster
Year: 2021

description: Replication stress, a hallmark of pre-cancerous and cancerous lesions, is characterised by the slowing or stalling in replication fork progression and the consequent failure to preserve genomic stability. ZFP36L1, a member of the ZFP36 family of CCCH tandem zinc finger (ZF) proteins, is an RNA-binding protein that plays a crucial role in the post-transcriptional regulation of gene expression underlying physiological processes and pathological diseases. Recent evidence has revealed that ZFP36L1, is significantly mutated or downregulated in certain human cancers, and exhibits tumour-suppressive properties across various cancer cell types. However, the precise molecular link between ZFP36L1 and cancer, particularly from the angle of genomic stability, remains poorly elucidated. Here, we report a novel role for ZFP36L1, characterised in human U2OS and U2OS H2B-GFP osteosarcoma cells, in suppressing replication stress-induced genomic instability. We found that, CRISPR/Cas9-mediated knockout of ZFP36L1 resulted in increased chromosome segregation defects including anaphase bridges, chromosome laggards and micronuclei formation, even in the absence of exogenous replication stress. Moreover, ZFP36L1-deficient cells exhibited an elevated accumulation of γH2AX, 53BP1 nuclear bodies (NBs) and RPA, which indicated an active role for ZFP36L1 in limiting replication stress-induced DNA damage. Furthermore, we demonstrated an unanticipated function for ZFP36L1 in potentially suppressing the expression of common fragile sites (CFSs) in response to replication stress, reflected by the increased mitotic CFS-characteristic chromosomal aberrations and MiDAS events at CFS loci observed in cells deficient in ZFP36L1. Finally, we also showed that a CRISPR/Cas9-mediated truncation in ZFP36L1, carrying a compromised lead-in sequence to its first ZF-domain, resulted in increased replication stress-associated phenotypes, similar to that of a ZFP36L1-knockout. Taken together, our data reveal, for the first time, a role for ZFP36L1 in contributing to the protection of genomic integrity against replication stress.
The $π^0-η-η'$ mixing in a generalized multi-quark interaction scheme
Creators: name: Osipov, Alexander A.
name: Hiller, Brigitte
name: Blin, Alex H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the isospin symmetry breaking effects within a recently derived Nambu-Jona-Lasinio related model by fitting the measured pseudoscalar meson masses and weak decay couplings $f_π$, $f_K$. Our model contains the next to leading order terms in the $1/N_c$ expansion of the effective multi-quark Lagrangian, including the ones that break the chiral symmetry explicitly. We show the important phenomenological role of these interactions: (1) they lead to an accurate fit of the low-lying pseudoscalar nonet characteristics; (2) they account for a very good agreement of the current quark masses with the present PDG values; (3) they reduce by $40\%$ the ratio $ε/ε'$ of the $π_0-η$ and $π_0-η'$ mixing angles, as compared to the case that contemplates explicit breaking only in the leading order, bringing it in consonance with the quoted values in the literature. The conventional NJL-type models fail in the joint description of these parameters.
description: 13 pages, 8 tables, version to appear in Phys. Rev. D
Meta-analysis of loci associated with age at natural menopause in African-American women
Creators: name: Liu, C.-T.
name: Lohman, K. K.
name: Brzyski, R. G.
name: Heiss, G.
name: Couper, D.
name: Carlson, C. S.
name: Cappola, A.
name: Musani, S. K.
name: Franceschini, N.
name: Ambrosone, C. B.
name: Britton, A.
name: Smith, J.
name: Li, G.
name: Andrews, J. S.
name: Arnold, A. M.
name: Deming, S. L.
name: Kerr, K. F.
name: Le Marchand, L.
name: Millikan, R.
name: Raffel, L. J.
name: Mcknight, B.
name: Lu, X.
name: Bandera, E. V.
name: Marciante, K.
name: Nalls, M. A.
name: Goodarzi, M. O.
name: John, E. M.
name: Chen, G. K.
name: Chen, C. T. L.
name: Garcia, M. E.
name: Bernstein, L.
name: Dreyfus, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.
The Australian Macro Database: An online resource for macroeconomic research in Australia
Creators: name: Behlul, Timur
name: Panagiotelis, Anastasios
name: Athanasopoulos, George
name: Hyndman, Rob J
name: Vahid, Farshid
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: A website that encourages and facilities the use of quantitative, publicly available Australian macroeconomic data is introduced.
The Fermionic Projector in a Time-Dependent External Potential: Mass Oscillation Property and Hadamard States
Creators: name: Finster, Felix
name: Murro, Simone
name: Röken, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We give a non-perturbative construction of the fermionic projector in Minkowski space coupled to a time-dependent external potential which is smooth and decays faster than quadratically for large times. The weak and strong mass oscillation properties are proven. We show that the integral kernel of the fermionic projector is of Hadamard form, provided that the time integral of the spatial sup-norm of the potential satisfies a suitable bound. This gives rise to an algebraic quantum field theory of Dirac fields in an external potential with a distinguished pure quasi-free Hadamard state.
description: 38 pages, LaTeX, 1 figure, references added, minor improvements (published version)
Recovery of interior eigenvalues from reduced near field data
Creators: name: Lakshtanov, Evgeny
name: Vainberg, Boris
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider inverse obstacle and transmission scattering problems where the source of the incident waves is located on a smooth closed surface that is a boundary of a domain located outside of the obstacle/inhomogeneity of the media. The domain can be arbitrarily small but fixed.The scattered waves are measured on the same surface. An effective procedure is suggested for recovery of interior eigenvalues by these data.
description: Minor changes are made in the text and title, references are added
Multi-ethnic fine-mapping of 14 central adiposity loci
Creators: name: Buchkovich, M. L.
name: North, K. E.
name: Winkler, T. W.
name: Fox, C. S.
name: Borecki, I. B.
name: Heid, I. M.
name: Mohlke, K. L.
name: Liu, C.-T.
name: Adrienne Cupples, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Genetic Investigation of Anthropometric Traits (GIANT) consortium identified 14 loci in European Ancestry (EA) individuals associated with waist-to-hip ratio (WHR) adjusted for body mass index. These loci are wide and narrowing the signals remains necessary. Twelve of 14 loci identified in GIANT EA samples retained strong associations with WHR in our joint EA/individuals of African Ancestry (AA) analysis (log-Bayes factor >6.1). Trans-ethnic analyses at five loci (TBX15-WARS2, LYPLAL1, ADAMTS9, LY86 and ITPR2-SSPN) substantially narrowed the signals to smaller sets of variants, some of which are in regions that have evidence of regulatory activity. By leveraging varying linkage disequilibrium structures across different populations, single-nucleotide polymorphisms (SNPs) with strong signals and narrower credible sets from trans-ethnic meta-analysis of central obesity provide more precise localizations of potential functional variants and suggest a possible regulatory role. Meta-analysis results for WHR were obtained from 77 167 EA participants from GIANT and 23 564 AA participants from the African Ancestry Anthropometry Genetics Consortium. For fine mapping we interrogated SNPs within ±250 kb flanking regions of 14 previously reported index SNPs from loci discovered in EA populations by performing trans-ethnic meta-analysis of results from the EA and AA meta-analyses. We applied a Bayesian approach that leverages allelic heterogeneity across populations to combine meta-analysis results and aids in fine-mapping shared variants at these locations. We annotated variants using information from the ENCODE Consortium and Roadmap Epigenomics Project to prioritize variants for possible functionality.
An overview on the seismic design of braced frames
Creators: name: Khoso, Salim
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400504
subject: Construction engineering
classificationCode: 400505
subject: Construction materials
classificationCode: 400506
subject: Earthquake engineering
classificationCode: 400509
subject: Structural dynamics
classificationCode: 400510
subject: Structural engineering

description: Seismic design of steel braced frames in the modern building codes follow the capacity design approach where some of the members are obliged to dissipate energy whereas others are taken care to be protected. In this paper the seismic design methodologies used by European and American approaches for Concentric Cross Braced Frames (CCBF) and Eccentric Braced Frames (EBF) are highlighted. Synoptic tables for the design of such frames of the most advance seismic codes i.e., Eurocode 8 and the seismic provisions of American Institute of Steel Construction (AISC) are provided. Emphasizes are made on the provisions of Eurocode 8 both for CCBF and EBF. Finally, a general conclusion is drawn when dealing with CCBF and EBF.
Echocardiographic Clustering by Machine Learning in Children with Early Surgically Corrected Congenital Heart Disease
Creators: name: Chien, Wei-Hsuan
name: Rodriguez Rivero, Cristian
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320101
subject: Cardiology (incl. cardiovascular diseases)
classificationCode: 461103
subject: Deep learning
classificationCode: 461104
subject: Neural networks
classificationCode: 461106
subject: Semi- and unsupervised learning

description: The research investigates the time-series clustering from echocardiographic data in children with surgically corrected congenital heart disease (CHD). In recent years, machine learning has been demonstrated to discover sophisticated latent patterns in medical data, yet relevant explainable applications in pediatric cardiology remain lacking. To address this issue, we propose an autoencoder based architecture to model time-series data with interpretable results effectively.
Bethe Ansatz and the Spectral Theory of affine Lie algebra-valued connections I. The simply-laced case
Creators: name: Masoero, Davide
name: Raimondo, Andrea
name: Valeri, Daniele
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Representation Theory (math.RT)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 82B23, 17B67, 34M40, 37K30

description: We study the ODE/IM correspondence for ODE associated to $\hat{\mathfrak g}$-valued connections, for a simply-laced Lie algebra $\mathfrak g$. We prove that subdominant solutions to the ODE defined in different fundamental representations satisfy a set of quadratic equations called $Ψ$-system. This allows us to show that the generalized spectral determinants satisfy the Bethe Ansatz equations.
description: 27 pages, final and published version. Minor change in the title
Macroeconomic forecasting for Australia using a large number of predictors
Creators: name: Jiang, Bin
name: Athanasopoulos, George
name: Hyndman, Rob J
name: Panagiotelis, Anastasios
name: Vahid, Farshid
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: A popular approach to forecasting macroeconomic variables is to utilize a large number of predictors. Several regularization and
Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage–hair hypoplasia
Creators: name: Rahimzadeh, Joseph
name: Notarangelo, Luigi D.
name: Kutchko, Katrina
name: Bebawee, Remon
name: Rogler, Charles E.
name: Roy-Chowdhury, Jayanta
name: Frenette, Paul
name: Moskowitz, David
name: Giliani, Silvia
name: Kosmyna, Brian
name: Laederach, Alain
name: Rogler, Leslie E.
name: Bouhassira, Eric
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Post-transcriptional processing of some long non-coding RNAs (lncRNAs) reveals that they are a source of miRNAs. We show that the 268-nt non-coding RNA component of mitochondrial RNA processing endoribonuclease, (RNase MRP), is the source of at least two short (∼20 nt) RNAs designated RMRP-S1 and RMRP-S2, which function as miRNAs. Point mutations in RNase MRP cause human cartilage–hair hypoplasia (CHH), and several disease-causing mutations map to RMRP-S1 and -S2. SHAPE chemical probing identified two alternative secondary structures altered by disease mutations. RMRP-S1 and -S2 are significantly reduced in two fibroblast cell lines and a B-cell line derived from CHH patients. Tests of gene regulatory activity of RMRP-S1 and -S2 identified over 900 genes that were significantly regulated, of which over 75% were down-regulated, and 90% contained target sites with seed complements of RMRP-S1 and -S2 predominantly in their 3′ UTRs. Pathway analysis identified regulated genes that function in skeletal development, hair development and hematopoietic cell differentiation including PTCH2 and SOX4 among others, linked to major CHH phenotypes. Also, genes associated with alternative RNA splicing, cell proliferation and differentiation were highly targeted. Therefore, alterations RMRP-S1 and -S2, caused by point mutations in RMRP, are strongly implicated in the molecular mechanism of CHH.
O'ZBEKISTONDA MEVA-SABZAVOT MAHSULOTLARI  BOZORINING HAJMI VA UNING RIVOJLANISHI
Creators: name: Minojidinov, Abdulvosid
Publisher: name: Zenodo
Year: 2023

description: Mamlakatimiz iqtisodiyotida qishloq xo'jaligi eng ustivor va muhim salohiyatga ega bo'lgan tarmoq xisoblanadi. Shunga ko'ra yildan yilga unga bo'lgan e'tibor va uning istiqboli uchun muhim qarorlar va imkoniyatlar yaratib berilmoqda. Ularning samarasi o'laroq, bugungi kunda qishloq xo'jaligi maxsulotlari ishlab chiqarish hajmi milliy ite'moldan bir necha barobar oshdi.
The Politics of Self-Representation
Creators: name: Matas Moris, Barbara
Publisher: name: University of Westminster
Year: 2021

description: I am a visual artist who has been making film and videos since completing a Masters of Fine Arts in Moving Image at California Institute of the Arts (CalArts) in 2002. I situate my practice amongst Experimental and Avant-Garde filmmakers and visual artists, however, unlike many of them I work with narrative, humour and specifically play with Hispanic American themes and aesthetics. This commentary focuses on four of my films made in the last ten years: Chica Pop (2010), Loin, Encore Plus Loin (Further, Even Further Away) (2016), La Puta, La Santa y La Viuda (The Whore, the Saint and the Widow) (2018) and Politics and Eggs (2019). I write, direct, perform and edit my own work with very limited external funds. I make low budget films, shot at home or in the street, using myself, friends and family as actors. This is done in combination with imagery obtained from the internet which I alter in post-production in order to create artisanal animations and video collages. This purposeful artisanal approach to animation, video-collage, rough sound and image treatment helps me to position my work in an ironic confrontation with mainstream cinema and in affiliation with avant-garde / experimental filmmaking and earlier Counter Cinema. My work draws from my familial experience of living in exile. My parents were exiled from Chile during Pinochet’s dictatorship (1973-1989). My father, Percy Matas is also a filmmaker and together with Raul Ruiz made a series of films about the Chilean exile in France (1973-1978). These films were performed and made by Chilean exiles and their families and became an historical document of Chilean exile in France during the 1970s. This approach to making film in the first person greatly influenced my own practice as it made me aware of the politics of selfrepresentation. Self- representation is at the core of my work, however, through this PhD research I have found many other unsuspected connections between my films that encompass the modes of production, including humour, post-production techniques, Hispanic American themes and aesthetics. I have realized how my experience of exile is always present in my films together with issues of cultural identity, displacement and gender. Analysing my films retrospectively has helped me to recognize the continuity and progression in my work, providing me with a clearer idea of where my practice needs to go in the future. The analysis of these four films serves as a platform from where to engage in a broader discussion about self- representation in film. My intention to underscore connections between the personal experience and politics represents an example of how self-representation can still stablish the personal as political in film. Reclaiming self-representation as a powerful political tool even in our time of social media’s exaltation of the visual, the personal still remains political.
MPEC 2024-R299 : 2024 RQ14
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RQ14

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Anisotropic critical-state model of type-II superconducting slabs
Creators: name: Li, Yingxu
name: Gao, Yuanwen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We introduce a critical-state model incorporating the anisotropy of flux-line pinning to analyze the critical states developing in an anisotropic biaxial superconducting slab exposed to a uniform perpendicular magnetic field and to two crossed in-plane magnetic fields which are applied successively. The theory is an extension of the anisotropic collective pinning theory developed by Mikitik and Brandt. The anisotropic flux-line pinning enters into the critical states by generating the angular dependence of the critical current density and by deviating the direction of the electric field from the current in the plane perpendicular to the vortex line. We find that an enhanced in-plane anisotropy moderates the gradients of the magnitudes of the magnetic field and the electric field along the slab thickness, however increases the gradients of their rotations.
Wiechert’sche Erdbebenwarte in Göttingen weiterhin aktiv
Creators: name: Wedeken, U.
name: Zürn, V.
name: Brunk, W.
Publisher: name: FID GEO
Year: 2021
Subjects: subject: 550
subject: Seismische Instrumente, Observatorien {Seismologie}
subject: Wiechert-Seismographen
subject: 17t-Pendel
subject: STS-2
subject: Bombensprengung
subject: GTT
subject: GTTG
subject: Vergleichsmessung
subject: FID-GEO-DE-7

description: Die 1902 von Emil Wiechert errichtete Göttinger Erdbebenstation GTT ist heute noch voll funktionsfähig und wird seit 2005 vom Verein Wiechert'sche Erdbebenwarte Göttingen betreut und von vielen Besuchern bestaunt. Die Registrierung einer 3 km entfernten Bombensprengung zeigt eindrucksvoll die große Übereinstimmung der Seismogramme des 17t-Pendels von GTT und dem benachbarten STS-2-Breitbandseismometer der Station GTTG.
description: DFG, SUB Göttingen
description: research
Matrix models and eigenvalue statistics for truncations of classical ensembles of random unitary matrices
Creators: name: Killip, Rowan
name: Kozhan, Rostyslav
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider random non-normal matrices constructed by removing one row and column from samples from Dyson's circular ensembles or samples from the classical compact groups. We develop sparse matrix models whose spectral measures match these ensembles. This allows us to compute the joint law of the eigenvalues, which have a natural interpretation as resonances for open quantum systems or as electrostatic charges located in a dielectric medium. Our methods allow us to consider all values of $β>0$, not merely $β=1,2,4$.
description: 36 pp, to appear in Comm. Math. Phys
Peter Polis (1869–1929) Meteorologe und Mitgründer der DGG
Creators: name: Jacobs, Franz
name: Börngen, Michael
Publisher: name: FID GEO
Year: 2021
Subjects: subject: 550
subject: Peter Polis
subject: Meteorologiegeschichte
subject: FID-GEO-DE-7

description: Aus Anlass des 100. Jahrestages der Gründung der Deutschen Geophysikalischen Gesellschaft im Jahre 1922 in Leipzig erschien im Verlag Edition am Gutenbergplatz Leipzig das Taschenbuch „Wiechert, Mintrop & Co. – Die 24 Gründungsväter der Deutschen Geophysikalischen Gesellschaft“ von Franz Jacobs und Michael Börngen (siehe gleichlautenden Archivbeitrag in DGG-Mitteilungen 1/2019: 36–37). Die DGG-Präsidentin Heidrun Kopp hat darin das Geleitwort geschrieben. Das Buch kann über den Buchhandel unter ISBN 978-3-95922-107-8 bestellt werden. Der folgende Artikel über den Aachener Meteorologen Peter Polis ist ein leicht erweitertes Kapitel aus diesem Buch.
description: DFG, SUB Göttingen
description: research
Coherent Probabilistic Forecasts for Hierarchical Time Series
Creators: name: Taieb, Souhaib Ben
name: Taylor, James W.
name: Hyndman, Rob J.
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Many applications require forecasts for a hierarchy comprising a set of time series along with aggregates of subsets of these series.
TGFBI ( IG-H3) is a diabetes-risk gene based on mouse and human genetic studies
Creators: name: Li, Y.
name: Qi, S.
name: Han, B.
name: Tremblay, J.
name: Hu, B.
name: Luo, H.
name: Wu, J.
name: Huang, J.
name: Raelson, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Transforming growth factor beta-induced (TGFBI/βIG-H3), also known as βig-H3, is a protein inducible by TGFβ1 and secreted by many cell types. It binds to collagen, forms part of the extracellular matrix and interacts with integrins on the cell surface. Recombinant TGFBI and transgenic TGFBI overexpression can promote both islet survival and function. In this study, we generated TGFBI KO mice and further assessed TGFBI function and signaling pathways in islets. Islets from KO mice were of normal size and quantity, and these animals were normoglycemic. However, KO islet survival and function was compromised in vitro. In vivo, KO donor islets became inferior to wild-type donor islets in achieving normoglycemia when transplanted into KO diabetic recipients. TGFBI KO mice were more prone to straptozotocin-induced diabetes than the wild-type counterpart. Phosphoprotein array analysis established that AKT1S1, a molecule linking the AKT and mTORC1 signaling pathways, was modulated by TGFBI in islets. Phosphorylation of four molecules in the AKT and mTORC1 signaling pathway, i.e. AKT, AKT1S1, RPS6 and EIF4EBP1, was upregulated in islets upon TGFBI stimulation. Suppression of AKT activity by a chemical inhibitor, or knockdown of AKT1S1, RPS6 and EIF4EBP1 expression by small interfering RNA, modulated islet survival, proving the relevance of these molecules in TGFBI-triggered signaling. Human genetic studies revealed that in the TGFBI gene and its vicinity, three single-nucleotide polymorphisms were significantly associated with type 1 diabetes risks, and one with type 2 diabetes risks. Our study suggests that TGFBI is a potential risk gene for human diabetes.
Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region
Creators: name: Bartolomei, M. S.
name: Ideraabdullah, F. Y.
name: Myers, J. A.
name: Thorvaldsen, J. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Parent-of-origin-specific expression at imprinted genes is regulated by allele-specific DNA methylation at imprinting control regions (ICRs). This mechanism of gene regulation, where one element controls allelic expression of multiple genes, is not fully understood. Furthermore, the mechanism of gene dysregulation through ICR epimutations, such as loss or gain of DNA methylation, remains a mystery. We have used genetic mouse models to dissect ICR-mediated genetic and epigenetic regulation of imprinted gene expression. The H19/insulin-like growth factor 2 (Igf2) ICR has a multifunctional role including insulation, activation and repression. Microdeletions at the human H19/IGF2 ICR (IC1) are proposed to be responsible for IC1 epimutations associated with imprinting disorders such as Beckwith–Wiedemann syndrome (BWS). Here, we have generated and characterized a mouse model that mimics BWS microdeletions to define the role of the deleted sequence in establishing and maintaining epigenetic marks and imprinted expression at the H19/IGF2 locus. These mice carry a 1.3 kb deletion at the H19/Igf2 ICR [Δ2,3] removing two of four CCCTC-binding factor (CTCF) sites and the intervening sequence, ∼75% of the ICR. Surprisingly, the Δ2,3 deletion does not perturb DNA methylation at the ICR; however, it does disrupt imprinted expression. While repressive functions of the ICR are compromised by the deletion regardless of tissue type, insulator function is only disrupted in tissues of mesodermal origin where a significant amount of CTCF is poly(ADP-ribosyl)ated. These findings suggest that insulator activity of the H19/Igf2 ICR varies by cell type and may depend on cell-specific enhancers as well as posttranslational modifications of the insulator protein CTCF.
Bayesian estimation based on summary statistics: Double asymptotics and practice
Creators: name: Cheng, Tingting
name: Gao, Jiti
name: Phillips, Peter CB
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Ergodic theorem shows that ergodic averages of the posterior draws converge in probability to the posterior mean under the stationarity assumption. The literature
Exploring π-Dimensional Spacetime: A Fractal Framework for Addressing Singularities and Potentially Unifying Relativity with Quantum Mechanics
Creators: name: Kanade, Chaitanya Anand
Publisher: name: Zenodo
Year: 2024
Subjects: relativity
quantum mechanics
spacetime

description: AbstractThe incompatibility between general relativity and quantum mechanicshas posed one of the greatest challenges in modern physics,particularly in addressing singularities and reconciling spacetime’s behaviorat large and small scales. In this paper, we explore a new modelof spacetime—π-dimensional spacetime—motivated by the observationthat, while we can move freely in the three spatial dimensions,time behaves asymmetrically, moving only forward. We intuitivelycan see π - 3 as a natural descriptor for time’s unidirectional, fractal,and infinite nature. By modifying key cosmological equations and incorporatingfractal structures, this model addresses singularities andsuggests new testable predictions for cosmic phenomena such as theCosmic Microwave Background, galaxy distribution, and gravitationalwaves. The π-dimensional spacetime could offer a promising frameworkfor unifying general relativity and quantum mechanics.
Wiechert’sche Erdbebenwarte Göttingen - Auswertung seismischer Daten als Thema einer Facharbeit
Creators: name: Schmitt, P.
name: Wedeken, U.
name: Zürn, V.
Publisher: name: FID GEO
Year: 2022
Subjects: subject: 551.22
subject: 550
subject: GTT
subject: GTTG
subject: STS-2-Seismometer
subject: Wiechert-Seismographen
subject: Nahbeben
subject: Vergleiche
subject: FID-GEO-DE-7

description: Während der Corona-Pandemie schrieb der Schüler Pascal Schmitt mit Unterstützung des Vereins Wiechert'sche Erdbebenwarte Göttingen e.V. im "Homeschooling" eine Facharbeit über die Auswertung seismischer Daten. Darin werden einige Daten eines Nah- und eines Fernbebens analysiert, die in Göttingen an der modernen Station GTTG (STS-2-Seismometer) und der historischen Station GTT (Wiechert-Seismographen) registriert wurden - nah und fern, neu und alt werden miteinander verglichen.
description: DFG, SUB Göttingen
description: research
From transience to recurrence with Poisson tree frogs
Creators: name: Hoffman, Christopher
name: Johnson, Tobias
name: Junge, Matthew
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Consider the following interacting particle system on the $d$-ary tree, known as the frog model: Initially, one particle is awake at the root and i.i.d. Poisson many particles are sleeping at every other vertex. Particles that are awake perform simple random walks, awakening any sleeping particles they encounter. We prove that there is a phase transition between transience and recurrence as the initial density of particles increases, and we give the order of the transition up to a logarithmic factor.
description: Published at http://dx.doi.org/10.1214/15-AAP1127 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans
Creators: name: Haessler, Jeffrey
name: Auer, Paul L.
name: Carty, Cara L.
name: Heard-Costa, Nancy
name: Willer, Cristen J.
name: Carlson, Christopher S.
name: Du, Mengmeng
name: Rich, Stephen S.
name: Reiner, Alex P.
name: Boerwinkle, Eric
name: Curtis, Keith
name: Lettre, Guillaume
name: Jackson, Rebecca
name: Rosse, Stephanie A.
name: Jiao, Shuo
name: Wilson, James G.
name: Franceschini, Nora
name: Lange, Leslie A.
name: Peters, Ulrike
name: Monda, Keri L.
name: North, Kari
name: Rotter, Jerome I.
name: Kooperberg, Charles
name: Altshuler, David
name: Nickerson, Deborah A.
name: Hsu, Li
name: Chen, Yii-Der Ida
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Adult body height is a quantitative trait for which genome-wide association studies (GWAS) have identified numerous loci, primarily in European populations. These loci, comprising common variants, explain <10% of the phenotypic variance in height. We searched for novel associations between height and common (minor allele frequency, MAF ≥5%) or infrequent (0.5% < MAF < 5%) variants across the exome in African Americans. Using a reference panel of 1692 African Americans and 471 Europeans from the National Heart, Lung, and Blood Institute's (NHLBI) Exome Sequencing Project (ESP), we imputed whole-exome sequence data into 13 719 African Americans with existing array-based GWAS data (discovery). Variants achieving a height-association threshold of P < 5E−06 in the imputed dataset were followed up in an independent sample of 1989 African Americans with whole-exome sequence data (replication). We used P < 2.5E−07 (=0.05/196 779 variants) to define statistically significant associations in meta-analyses combining the discovery and replication sets (N = 15 708). We discovered and replicated three independent loci for association: 5p13.3/C5orf22/rs17410035 (MAF = 0.10, β = 0.64 cm, P = 8.3E−08), 13q14.2/SPRYD7/rs114089985 (MAF = 0.03, β = 1.46 cm, P = 4.8E−10) and 17q23.3/GH2/rs2006123 (MAF = 0.30; β = 0.47 cm; P = 4.7E−09). Conditional analyses suggested 5p13.3 (C5orf22/rs17410035) and 13q14.2 (SPRYD7/rs114089985) may harbor novel height alleles independent of previous GWAS-identified variants (r2 with GWAS loci <0.01); whereas 17q23.3/GH2/rs2006123 was correlated with GWAS-identified variants in European and African populations. Notably, 13q14.2/rs114089985 is infrequent in African Americans (MAF = 3%), extremely rare in European Americans (MAF = 0.03%), and monomorphic in Asian populations, suggesting it may be an African-American-specific height allele. Our findings demonstrate that whole-exome imputation of sequence variants can identify low-frequency variants and discover novel variants in non-European populations.
Luise Charlotte Lammert (1887–1946) – Schriftführerin bei der DGG-Gründung 1922 in Leipzig
Creators: name: Börngen, Michael
name: Lüdecke, Cornelia
name: Jacobs, Franz
Publisher: name: FID GEO
Year: 2022
Subjects: subject: 550
subject: Luise Charlotte Lammert
subject: FID-GEO-DE-7

description: Aus Anlass des 100. Jahrestages der Gründung der Deutschen Geophysikalischen Gesellschaft im Jahre 1922 in Leipzig erschien 2019 im Verlag Edition am Gutenbergplatz Leipzig das Taschenbuch „Wiechert, Mintrop & Co. – Die 24 Gründungsväter der Deutschen Geophysikalischen Gesellschaft“ von Franz Jacobs und Michael Börngen (s. gleichlautenden Archivbeitrag in DGG-Mitteilungen, 1/2019: 36–37 sowie das anbei dargestellte Titelblatt des Buches). Die damalige Präsidentin und heutige Vize-Präsidentin der DGG, Heidrun Kopp, hat mit einem Geleitwort beigetragen. Das Buch kann über den Buchhandel unter ISBN 978-3-95922-107-8 bestellt werden. Der folgende Artikel erinnert an die Meteorologin Luise Lammert, Schriftführerin der Versammlung, auf der der Gründungsbeschluss gefasst wurde.
description: DFG, SUB Göttingen
description: research
Quantitative Wave-Particle Duality
Creators: name: Qureshi, Tabish
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The complementary wave and particle character of quantum objects (or quantons) was pointed out by Niels Bohr. This wave-particle duality, in the context of the two-slit experiment, is now described not just as two extreme cases of wave and particle characteristics, but in terms of quantitative measures of these natures. These measures of wave and particle aspects are known to follow a duality relation. A very simple and intuitive derivation of a closely related duality relation is presented, which should be understandable to the introductory student.
description: Closest to the published version, 5 pages
Association of exome sequences with plasma C-reactive protein levels in >9000 participants
Creators: name: Girelli, Domenico
name: Willer, Cristen
name: Brody, Jennifer
name: Boerwinkle, Eric
name: Bis, Joshua C.
name: Haessler, Jeffery
name: Jackson, Rebecca D.
name: Fontanillas, Pierre
name: Leal, Suzanne M.
name: Wei, Peng
name: Fornage, Myriam
name: Ardissino, Diego
name: Watkins, Hugh
name: Kim, Daniel S.
name: Stitziel, Nathan O.
name: Reilly, Muredach
name: Lin, Honghuang
name: Schick, Ursula M.
name: Melander, Olle
name: Auer, Paul L.
name: Loos, Ruth
name: Carlson, Christopher S.
name: Shah, Svati
name: Hsu, Li
name: Pankratz, Nathan
name: Mcpherson, Ruth
name: Chasman, Daniel I.
name: Kooperberg, Charles
name: Hovingh, Kees
name: Psaty, Bruce M.
name: Lange, Leslie A.
name: Tracy, Russell
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: C-reactive protein (CRP) concentration is a heritable systemic marker of inflammation that is associated with cardiovascular disease risk. Genome-wide association studies have identified CRP-associated common variants associated in ∼25 genes. Our aims were to apply exome sequencing to (1) assess whether the candidate loci contain rare coding variants associated with CRP levels and (2) perform an exome-wide search for rare variants in novel genes associated with CRP levels. We exome-sequenced 6050 European-Americans (EAs) and 3109 African-Americans (AAs) from the NHLBI-ESP and the CHARGE consortia, and performed association tests of sequence data with measured CRP levels. In single-variant tests across candidate loci, a novel rare (minor allele frequency = 0.16%) CRP-coding variant (rs77832441-A; p.Thr59Met) was associated with 53% lower mean CRP levels (P = 2.9 × 10−6). We replicated the association of rs77832441 in an exome array analysis of 11 414 EAs (P = 3.0 × 10−15). Despite a strong effect on CRP levels, rs77832441 was not associated with inflammation-related phenotypes including coronary heart disease. We also found evidence for an AA-specific association of APOE-ε2 rs7214 with higher CRP levels. At the exome-wide significance level (P < 5.0 × 10−8), we confirmed associations for reported common variants of HNF1A, CRP, IL6R and TOMM40-APOE. In gene-based tests, a burden of rare/lower frequency variation in CRP in EAs (P ≤ 6.8 × 10−4) and in retinoic acid receptor-related orphan receptor α (RORA) in AAs (P = 1.7 × 10−3) were associated with CRP levels at the candidate gene level (P < 2.0 × 10−3). This inquiry did not elucidate novel genes, but instead demonstrated that variants distributed across the allele frequency spectrum within candidate genes contribute to CRP levels.
Yang-Baxter Maps, Discrete Integrable Equations and Quantum Groups
Creators: name: Bazhanov, Vladimir V.
name: Sergeev, Sergey M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: For every quantized Lie algebra there exists a map from the tensor square of the algebra to itself, which by construction satisfies the set-theoretic Yang-Baxter equation. This map allows one to define an integrable discrete quantum evolution system on quadrilateral lattices, where local degrees of freedom (dynamical variables) take values in a tensor power of the quantized Lie algebra. The corresponding equations of motion admit the zero curvature representation. The commuting Integrals of Motion are defined in the standard way via the Quantum Inverse Problem Method, utilizing Baxter's famous commuting transfer matrix approach. All elements of the above construction have a meaningful quasi-classical limit. As a result one obtains an integrable discrete Hamiltonian evolution system, where the local equation of motion are determined by a classical Yang-Baxter map and the action functional is determined by the quasi-classical asymptotics of the universal R-matrix of the underlying quantum algebra. In this paper we present detailed considerations of the above scheme on the example of the algebra $U_q(sl(2))$ leading to discrete Liouville equations, however the approach is rather general and can be applied to any quantized Lie algebra.
description: 36 pages, 7 figures, v2: minor corrections, references added
Recursive estimation in large panel data models: Theory and practice
Creators: name: Jiang, Bing
name: Yang, Yanrong
name: Gao, Jiti
name: Hsiao, Cheng
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Bai (2009) proposes a recursive least-squares estimation method for large panel data models
$q$-Borel-Laplace summation for $q$-difference equations with two slopes
Creators: name: Dreyfus, Thomas
name: Eloy, Anton
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 39A13

description: In this paper, we consider linear $q$-difference systems with coefficients that are germs of meromorphic functions, with Newton polygon that has two slopes. Then, we explain how to compute similar meromorphic gauge transformations than those appearing in the work of Bugeaud, using a $q$-analogue of the Borel-Laplace summation.
description: The final version of this paper will be published in Journal of Difference Equations and Applications
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
Creators: name: Levy, Daniel
name: Pankow, James S.
name: Grove, Megan L.
name: Zhou, Yi-Hui
name: Hedman, Åsa K.
name: Irvin, Marguerite R.
name: Liu, Chunyu
name: Li, Li-An
name: Absher, Devin M.
name: Guan, Weihua
name: Bressler, Jan
name: Liang, Liming
name: Demerath, Ellen W.
name: Aslibekyan, Stella
name: Deloukas, Panos
name: Sandling, Johanna K.
name: Boerwinkle, Eric
name: North, Kari
name: Spector, Tim D.
name: Arnett, Donna K.
name: Zhi, Degui
name: Li, Yun
name: Fornage, Myriam
name: Mendelson, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA obtained from 2097 African American adults in the Atherosclerosis Risk in Communities (ARIC) study. Mixed-effects regression models were used to test the association of methylation beta value with concurrent body mass index (BMI) and waist circumference (WC), and BMI change, adjusting for batch effects and potential confounders. Replication using whole-blood DNA from 2377 White adults in the Framingham Heart Study and CD4+ T cell DNA from 991 Whites in the Genetics of Lipid Lowering Drugs and Diet Network Study was followed by testing using adipose tissue DNA from 648 women in the Multiple Tissue Human Expression Resource cohort. Seventy-six BMI-related probes, 164 WC-related probes and 8 BMI change-related probes passed the threshold for significance in ARIC (P < 1 × 10−7; Bonferroni), including probes in the recently reported HIF3A, CPT1A and ABCG1 regions. Replication using blood DNA was achieved for 37 BMI probes and 1 additional WC probe. Sixteen of these also replicated in adipose tissue, including 15 novel methylation findings near genes involved in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including LGALS3BP, KDM2B, PBX1 and BBS2, among others. Adiposity traits are associated with DNA methylation at numerous CpG sites that replicate across studies despite variation in tissue type, ethnicity and analytic approaches.