In vivo testing of a bioabsorbable magnesium alloy serving as total ossicular replacement prostheses
Creators: name: Lensing, Rebecca
name: Behrens, Peter
name: Müller, Peter Paul
name: Lenarz, Thomas
name: Stieve, Martin
Publisher: name: London : SAGE Publications Ltd.
Year: 2014
Subjects: subject: Animal model
subject: biodegradation
subject: magnesium alloy
subject: middle ear
subject: osteoinduction
subject: Bioabsorbable magnesium
subject: Bone reconstruction
subject: Histological examination
subject: Implant materials
subject: Middle ears
subject: New Zealand White rabbit
subject: Osteoinduction
subject: Animals
subject: Biocompatibility
subject: Biodegradation
subject: Biological materials
subject: Bone
subject: Epoxy resins
subject: Implants (surgical)
subject: Magnesium
subject: Plates (structural components)
subject: Magnesium alloys
subject: alloy
subject: epoxy resin
subject: magnesium
subject: animal experiment
subject: animal tissue
subject: article
subject: auditory ossicle
subject: biocompatibility
subject: bone implant
subject: bone remodeling
subject: cochlear nerve
subject: controlled study
subject: corrosion
subject: experimental rabbit
subject: external auditory canal
subject: female
subject: head tilting
subject: implant
subject: implantation
subject: in vivo study
subject: inflammation
subject: microscopy
subject: middle ear prosthesis
subject: middle ear surgery
subject: nerve injury
subject: nonhuman
subject: nystagmus
subject: ossification
subject: petrous bone
subject: priority journal
subject: stapes
subject: surface property
subject: trabecular bone
subject: wound healing impairment
subject: Alloys
subject: Biocompatible Materials
subject: Female
subject: Ossicular Prosthesis
subject: Rabbits
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Magnesium alloys have been investigated in different fields of medicine and represent a promising biomaterial for implants due to characteristics like bioabsorbability and osteoinduction. The objective of this study was to evaluate the usability of magnesium as implant material in middle ear surgery. Magnesium implants were placed into the right middle ear of eighteen New Zealand White rabbits. Nine animals were euthanized after four weeks and nine animals after three month. The petrous bones were removed and embedded in epoxy resin. The specimens were then polished, stained and evaluated with the aid of a light microscope. The histological examination revealed a good biocompatibility. After four weeks, a beginning corrosion of the implant's surface and low amount of trabecular bone formation in the area of the stapes base plate was observed. A considerable degradation of implants and obvious bone formation was found three month after implantation. The magnesium alloy used in the present study partly corroded too fast, so that a complete bone reconstruction could not be established in time. The increased osteoinduction on the stapes base plate resulted in a tight bone-implant bonding. Thus, a promising application of magnesium could be a coating of biomaterials in order to improve the bony integration of implants. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.