cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Psychopaths, Narcissists, Machiavellians, Toxic Leaders, Coercive Controllers: Subsets of One Overarching 'Dark' Personality Type?
Creators: name: Mitchell, Karen Lee
Publisher: name: Swinburne
Year: 2024

description: This thesis presents a model that is potentially the most comprehensive and nuanced representation yet developed of socially aversive personalities (Dark Personality, DP). The breadth of harm imposed by people of DP, including psychopaths, narcissists, and Machiavellians, is substantial and impacts millions of people daily in the most painful and destructive of ways. There is, however, substantial dissension regarding their shared attributes which is not in the interests of humankind, as identification of human predators is key to survival. New and unique approaches to research and highly knowledgeable research populations not previously canvassed for data were engaged for this study.
First direct measurement of the 64.5 keV resonance strength in $^{17}$O(p,$γ$)$^{18}$F reaction
Creators: name: Gesuè, R. M.
name: Ciani, G. F.
name: Piatti, D.
name: Boeltzig, A.
name: Rapagnani, D.
name: Aliotta, M.
name: Ananna, C.
name: Barbieri, L.
name: Barile, F.
name: Bemmerer, D.
name: Best, A.
name: Broggini, C.
name: Bruno, C. G.
name: Caciolli, A.
name: Campostrini, M.
name: Casaburo, F.
name: Cavanna, F.
name: Colombetti, P.
name: Compagnucci, A.
name: Corvisiero, P.
name: Csedreki, L.
name: Davinson, T.
name: De Gregorio, G. M.
name: Dell'Aquila, D.
name: Depalo, R.
name: Di Leva, A.
name: Elekes, Z.
name: Ferraro, F.
name: Formicola, A.
name: Fülöp, Zs.
name: Gervino, G.
name: Guglielmetti, A.
name: Gustavino, C.
name: Gyürky, Gy.
name: Imbriani, G.
name: Junker, M.
name: Lugaro, M.
name: Marigo, P.
name: Marsh, J.
name: Masha, E.
name: Menegazzo, R.
name: Mercogliano, D.
name: Paticchio, V.
name: Perrino, R.
name: Prati, P.
name: Rigato, V.
name: Robb, D.
name: Schiavulli, L.
name: Sidhu, R. S.
name: Skowronski, J.
name: Straniero, O.
name: Szücs, T.
name: Zavatarelli, S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The CNO cycle is one of the most important nuclear energy sources in stars. At temperatures of hydrostatic H-burning (20 MK $<$ T $<$ 80 MK) the $^{17}$O(p,$γ$)$^{18}$F reaction rate is dominated by the poorly constrained 64.5~keV resonance. Here we report on the first direct measurements of its resonance strength and of the direct capture contribution at 142 keV, performed with a new high sensitivity setup at LUNA. The present resonance strength of $ωγ_{(p, γ)}$\textsuperscript{bare} = (30 $\pm$ 6\textsubscript{stat} $\pm$ 2\textsubscript{syst})~peV is about a factor of 2 higher than the values in literature, leading to a $Γ$\textsubscript{p}\textsuperscript{bare} = (34 $\pm$ 7\textsubscript{stat} $\pm$ 3\textsubscript{syst})~neV, in agreement with LUNA result from the (p,$α$) channel. Such agreement strengthen our understanding of the oxygen isotopic ratios measured in red giant stars and in O-rich presolar grains.
Silvesterfeuerwerk: Einfluss auf Mensch und Umwelt
Creators: name: Dauert, Ute
name: Gerwig, Holger
name: Kessinger, Susan
name: Myck, Thomas
name: Kuntze, David
name: Straff, Wolfgang
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Feuerwerk
subject: Feinstaub
subject: Immissionsbelastung
subject: Silvesterfeuerwerk
subject: Luftbelastung
subject: Luft
subject: Air

description: Ein Feuerwerk ist schön anzusehen. Es hat aber auch negative Seiten: Verbrennungen, Augenverletzungen und Hörschädigungen, Explosionsschäden und andere Sachschäden an Fahrzeugen und Gebäuden, der Eintrag von Plastik in die Umwelt, enorme Müllmengen, verängstigte Haustiere sowie ökologische Schäden und die Störung von Wildtieren. Jährlich werden rund 2.050 Tonnen Feinstaub (PM10) durch das Abbrennen von Feuerwerkskörpern frei gesetzt, der größte Teil davon in der Silvesternacht. Diese Menge entspricht knapp einem Prozent der gesamt freigesetzten Feinstaubmenge in Deutschland. Die Broschüre zeigt anhand aktueller Auswertungen von Luftdaten, dass am ersten Tag des neuen Jahres die Luftbelastung mit gesundheitsgefährdendem Feinstaub vielerorts so hoch ist, wie sonst im ganzen Jahr nicht. Zudem fasst sie alle relevanten Wirkungen des Feuerwerks auf Mensch und Umwelt zusammen. Quelle: umweltbundesamt.de
description: Ein Feuerwerk ist schön anzusehen. Es hat aber auch negative Seiten: Verbrennungen, Augenverletzungen und Hörschädigungen, Explosionsschäden und andere Sachschäden an Fahrzeugen und Gebäuden, der Eintrag von Plastik in die Umwelt, enorme Müllmengen, verängstigte Haustiere sowie ökologische Schäden und die Störung von Wildtieren.Jährlich werden rund 2.050 Tonnen Feinstaub (⁠PM10⁠) durch das Abbrennen von Feuerwerkskörpern frei gesetzt, der größte Teil davon in der Silvesternacht. Diese Menge entspricht knapp einem Prozent der gesamt freigesetzten Feinstaubmenge in Deutschland. Die Broschüre zeigt anhand aktueller Auswertungen von Luftdaten, dass am ersten Tag des neuen Jahres die Luftbelastung mit gesundheitsgefährdendem Feinstaub vielerorts so hoch ist, wie sonst im ganzen Jahr nicht. Zudem fasst sie alle relevanten Wirkungen des Feuerwerks auf Mensch und Umwelt zusammen.
Supplementary document for Refined Prefrontal Working Memory Network as a Neuromarker for Alzheimer’s Disease - 5477390.pdf
Creators: name: Kim, Eunho
name: Yu, Jin-Woo
name: Kim, Bomin
name: Lim, Sung-Ho
name: Lee, Sang-Ho
name: Kim, Kwangsu
name: Son, Gowoon
name: Jeon, Hyeon-Ae
name: Moon, Cheil
name: Sakong, Joon
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supp.Text, Fig S1-2, and Table S1-S4
Injuries from falls by older adults in long-term care captured on video: Prevalence of impacts and injuries to body parts
Creators: name: Komisar, Vicki
name: Dojnov, Aleksandra
name: Yang, Yijian
name: Shishov, Nataliya
name: Chong, Helen
name: Yu, Ying
name: Bercovitz, Ian
name: Cusimano, Michael D.
name: Becker, Clemens
name: Mackey, Dawn C.
name: Robinovitch, Stephen N.
Publisher: name: BioMed Central
Year: 2022

description: Background Falls are the leading cause of injuries in older adults. However, most falls in older adults do not cause serious injury, suggesting that older adults may fall in a manner that reduces the likelihood of impact to body sites that are most vulnerable to injury. In this observational study of falls in long-term care (LTC), we tested whether body parts differed in their probability of impact and injury. Methods We recorded and analyzed videos of 2388 falls by 658 LTC residents (mean age 84.0 (SD = 8.1); 56.4% female). We used Linear Mixed Models to test for differences between body parts in the probability of impact and injury, and injury when impacts occurred. Results Injuries were reported in 38.2% of falls, and 85.9% of injuries involved direct impact to the injured body part. Impact occurred most often to the hip/pelvis (probability (standard error) = 0.95 (0.01); p < .001 relative to other body parts), and least often to the head (0.35 (0.01)). Conversely, injury occurred most often to the head (p < .001 relative to other body parts). The probability of injury when impacts occurred was 0.40 (0.01) for the head, and 0.11 or less for all other body parts. Conclusion Our results help to explain why most falls by older adults in LTC do not cause serious injury: residents land on body parts that are the most resilient to injury. The high susceptibility of the head to injury reinforces the need to enhance upper limb protective responses for fall arrest. The dominant role of direct impact as the mechanism of injury supports approaches to attenuate impact forces through strategies like protective clothing and compliant flooring.
Propuesta de guía para la elaboración de un cuestionario sobre la evaluación del uso de un prototipo para la prevención del riesgo cardiovascular en adultos mayores
Creators: name: Abrego Santana, Eric Magdiel
name: Vallejos Marín, Elbis Miguel
name: Marín Monterrey, Mitzy Mariley
name: Fung Corro, José Rogelio
name: CarrasquillaI, Indira
Publisher: name: Zenodo
Year: 2025

description: Propuesta de guía para la elaboración de un cuestionario sobre la evaluación del uso de un prototipo para la prevención del riesgo cardiovascular en adultos mayores, empleado en una investigación que contó con una muestra de 46 participantes: 14 fueron captados a través de la Asociación de Jubilados y Pensionados, mientras que 32 participantes fueron voluntarios en el MINSA CAPSI El Coco (centro de salud comunitario), ambos de La Chorrera, Panamá.
Dynamics Analysis and Parameter Identification for Industrial Robotic Manipulators
Creators: name: Zhu, Qianfeng
Publisher: name: Swinburne
Year: 2024

description: This thesis focuses on developing a systematic scheme for estimating all manipulator dynamic quantities with superior performance compared to conventional methods. System properties in the frequency domain are further explored. Only the joint position measurement is required to estimate all parameters and system states including joint velocity and acceleration. The proposed method is designed for a broad class of manipulators which means it can be applied to various kinds of industrial applications.
Probing structural constraints of negation in Pretrained Language Models
Creators: name: Kletz, David
name: Candito, Marie
name: Amsili, Pascal
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Contradictory results about the encoding of the semantic impact of negation in pretrained language models (PLMs). have been drawn recently (e.g. Kassner and Sch{ü}tze (2020); Gubelmann and Handschuh (2022)). In this paper we focus rather on the way PLMs encode negation and its formal impact, through the phenomenon of the Negative Polarity Item (NPI) licensing in English. More precisely, we use probes to identify which contextual representations best encode 1) the presence of negation in a sentence, and 2) the polarity of a neighboring masked polarity item. We find that contextual representations of tokens inside the negation scope do allow for (i) a better prediction of the presence of not compared to those outside the scope and (ii) a better prediction of the right polarity of a masked polarity item licensed by not, although the magnitude of the difference varies from PLM to PLM. Importantly, in both cases the trend holds even when controlling for distance to not. This tends to indicate that the embeddings of these models do reflect the notion of negation scope, and do encode the impact of negation on NPI licensing. Yet, further control experiments reveal that the presence of other lexical items is also better captured when using the contextual representation of a token within the same syntactic clause than outside from it, suggesting that PLMs simply capture the more general notion of syntactic clause.
Pleistozäne Säugetier-Reste und Schotterablagerungen aus dem mittleren Jagsttal zwischen Marlach und Kloster Schöntal (Hohenlohe, Baden-Württemberg)
Creators: name: Wolff, Gerd
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1991

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 146
Contrasting patterns of neutral and adaptive genetic variation in a montane philopatric species: implications for managing climate-driven range-shifts
Creators: name: Ofori, Benjamin
name: Beaumont, Linda
name: Stow, Adam
Publisher: name: F1000Research
Year: 2016

description: Creating corridors to increase dispersal and gene flow among isolated populations can enhance populations' adaptive potential and facilitate climate-driven range shifts. However, connecting diverging and locally adapted population could have adverse conservation implications.

Here we characterized the spatial patterns of neutral and adaptive genetic variation in Cunningham's skink, infer localities where the species is locally adapted and the environmental factors strongly associated with loci under destructive selection.

Our findings will be important for informing management strategies for conserving montane philopatric species under climate change.
Strong Uniform Consistency Rates of Conditional Density Estimation in the Single Functional Index Model for Functional Data Under Random Censorship
Creators: name: Kadiri, Nadia
name: Meghnafi, Mustapha
name: Rabhi, Abbes
Publisher: name: REVSTAT-Statistical Journal
Year: 2022

description: The main objective of this paper is to investigate the estimation of conditional density function based on the single-index model in the censorship model when the sample is considered as an independent and identically distributed (i.i.d.) random variables. First of all, a kernel type estimator for the conditional density function (cond-df) is introduced. Afterwards, the asymptotic properties are stated when the observations are linked with a single-index structure. The pointwise almost complete convergence and the uniform almost complete convergence (with rate) of the kernel estimate of this model are established. As an application the conditional mode in functional single-index model is presented. Finally, a simulation study is carried out to evaluate the performance of this estimate.
description: REVSTAT-Statistical Journal, Vol. 20 No. 2 (2022): REVSTAT-Statistical Journal
Lichenicolous fungi from the Schwäbische Alb, Baden-Württemberg - Flechtenbewohnende Pilze von der Schwäbischen Alb
Creators: name: Hawksworth, D. L.
name: Diederich, Paul
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1991

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 146
Supplementary document for Characterization of Cell-Induced Astigmatism in High-Resolution Imaging - 5477685.pdf
Creators: name: de Mercado, Rick Rodrigues
name: van Hoorn, Hedde
name: de Valois, Martin
name: Backendorf, Claude
name: Eckert, Julia
name: Schmidt, Thomas
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Biophysics

description: Supplemental Document
Nachhaltiger Konsum durch soziale Innovationen - Konzepte und Praxis
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Nachhaltiger Konsum
subject: Gemeinschaftlicher Konsum
subject: Grüne Wirtschaft
subject: Soziale Innovation
subject: Klooaborativer Konsum
subject: Green Economy
subject: sharing economy
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Für die Umsetzung des Ziels einer nachhaltigen Gestaltung der Gesellschaft ist ein struktureller Wandel des Konsums notwendig, durch den die bisher mehrheitlich praktizierten und für selbstverständlich angesehenen nicht nachhaltigen Praktiken verändert und durch nachhaltige Alternativen ersetzt werden. Sozialen Innovationen wird in diesem Zusammenhang ein hohes Veränderungspotenzial zugesprochen. Es wird erwartet, dass sie auf gesellschaftliche Probleme antworten und Lösungsvorschläge im Kontext eines nachhaltigeren Konsums zur Verfügung stellen. Mit dem Forschungsprojekt "Nachhaltiger Konsum durch soziale Innovationen - Konzepte und Praxis" wurden wesentliche Merkmale sozialer Innovationen nachhaltigen Konsums herausgearbeitet und in einer Typologie zusammengefasst.
Quelle: https://www.umweltbundesamt.de/
description: Für die Umsetzung des Ziels einer nachhaltigen Gestaltung der Gesellschaft ist ein struktureller Wandel des Konsums notwendig, durch den die bisher mehrheitlich praktizierten und für selbstverständlich angesehenen nicht nachhaltigen Praktiken verändert und durch nachhaltige Alternativen ersetzt werden. Sozialen Innovationen wird in diesem Zusammenhang ein hohes Veränderungspotenzial zugesprochen. Es wird erwartet, dass sie auf gesellschaftliche Probleme antworten und Lösungsvorschläge im Kontext eines nachhaltigeren Konsums zur Verfügung stellen. Mit dem Forschungsprojekt „Nachhaltiger Konsum durch soziale Innovationen – Konzepte und Praxis“ wurden wesentliche Merkmale sozialer Innovationen nachhaltigen Konsums herausgearbeitet und in einer Typologie zusammengefasst.
Search for flavour-changing neutral-current interactions of a top quark and a gluon in pp collisions at $$\sqrt{s}=13$$ s = 13 TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: Springer Berlin Heidelberg
Year: 2022

description: A search is presented for the production of a single top quark via left-handed flavour-changing neutral-current (FCNC) interactions of a top quark, a gluon and an up or charm quark. Two production processes are considered: $$u+g\rightarrow t$$ u + g → t and $$c+g\rightarrow t$$ c + g → t . The analysis is based on proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. The data set corresponds to an integrated luminosity of 139 fb $$^{-1}$$ - 1 . Events with exactly one electron or muon, exactly one b-tagged jet and missing transverse momentum are selected, resembling the decay products of a singly produced top quark. Neural networks based on kinematic variables differentiate between events from the two signal processes and events from background processes. The measured data are consistent with the background-only hypothesis, and limits are set on the production cross-sections of the signal processes: $$\sigma (u+g\rightarrow t)\times \mathcal {B}(t\rightarrow Wb)\times \mathcal {B}(W\rightarrow \ell \nu )<3.0\,$$ σ ( u + g → t ) × B ( t → W b ) × B ( W → ℓ ν ) < 3.0 pb and $$\sigma (c+g\rightarrow t)\times \mathcal {B}(t\rightarrow Wb)\times \mathcal {B}(W\rightarrow \ell \nu )<4.7\,$$ σ ( c + g → t ) × B ( t → W b ) × B ( W → ℓ ν ) < 4.7 pb at the 95% confidence level, with $$\mathcal {B}(W\rightarrow \ell \nu )=0.325$$ B ( W → ℓ ν ) = 0.325 being the sum of branching ratios of all three leptonic decay modes of the W boson. Based on the framework of an effective field theory, the cross-section limits are translated into limits on the strengths of the tug and tcg couplings occurring in the theory: $$|C^{\,ut}_{uG}|/\Lambda ^2 < 0.057\,$$ | C uG u t | / Λ 2 < 0.057 TeV $$^{-2}$$ - 2 and $$|C^{\,ct}_{uG}|/\Lambda ^2 < 0.14\,$$ | C uG c t | / Λ 2 < 0.14 TeV $$^{-2}$$ - 2 . These bounds correspond to limits on the branching ratios of FCNC-induced top-quark decays: $$\mathcal {B}(t\rightarrow u+g)< 0.61\times 10^{-4}$$ B ( t → u + g ) < 0.61 × 10 - 4 and $$\mathcal {B}(t\rightarrow c+g)< 3.7\times 10^{-4}$$ B ( t → c + g ) < 3.7 × 10 - 4 .
Nachzucht der Balearen-Geburtshelferkröte Alytes muletensis (SANCHIZ et ADROVER 1979) im Rahmen eines Artenschutzprogrammes (Amphibia: Discoglossidae)
Creators: name: König, Claus
name: Schlüter, Andreas
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1991

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 146
Kleiner Abendsegler (Nyctalus leiseri KUHL 1817) in einer Gesellschaft der Wasserfledermaus (Myotis daubentoni LEISLER in KUHL 1817) in Süddeutschland
Creators: name: Merz, Hubert
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1991

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 146
Das Urheberrecht als Fundamentalinstitution der Kulturindustrien
Creators: name: Fischer, Georg
Publisher: name: Zenodo
Year: 2022
Subjects: Urheberrecht, Musikindustrie, Verlagswesen, Soziologie, Lizenzierung, Verwertungsgesellschaften

description: Präsentation für die Tagung "Zu einer Soziologie des Rechts als Fundamentalinstitution der Wirtschaft"; Mittelbautagung der DGS-Sektion Wirtschaftssoziologie, 12./13. Mai 2022 in Hamburg (HIS).
Die Laufkäferfauna des Rosensteinparks und weiterer Grünflächen im Stadtgebiet von Stuttgart (Coleoptera, Carabidae)
Creators: name: Trautner, Jürgen
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1991

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 146
Η εκπαίδευση ως προσδιοριστικός παράγοντας του επιπέδου φτώχεια στην Ελλάδα
Creators: name: Παπαχατζή, Αικατερίνη
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Φτώχεια
subject: Εκπαίδευση
subject: Ακαθάριστο Εγχώριο Προϊόν

description: Η εκπαίδευση επηρεάζει σε μεγάλο βαθμό την εξέλιξη του ανθρώπου αλλά και τη συνοχή της κοινωνίας γενικότερα. Διαδραματίζει σημαντικό ρόλο στη διαμόρφωση του εισοδήματος και συνεπώς επηρεάζει την οικονομική ανισότητα και τα επίπεδα φτώχειας της κάθε χώρας. Η παρούσα εργασία παρουσιάζει τους οικονομικούς παράγοντες που επηρεάζουν τη φτώχεια στην Ελλάδα δίνοντας έμφαση στο εκπαιδευτικό επίπεδο των ανθρώπων. Χρησιμοποιώντας δεδομένα της Eurostat και της Organisation for Economic Co-operation and Development (OECD) για τα έτη 2000 έως 2020, γίνεται προσπάθεια εντοπισμού επιρροής των χαμηλότερων και των υψηλότερων επιπέδων της εκπαίδευσης στο φαινόμενο της φτώχειας. Τα αποτελέσματα της έρευνας απέδειξαν ότι το εκπαιδευτικό επίπεδο των ατόμων συμβάλει στην εξέλιξη του φαινομένου της φτώχειας και της οικονομίας της χώρας γενικότερα.
Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis
Creators: name: He, Jiali
name: Tang, Yiling
name: Lin, Jingxia
name: Faulkner, Guy E. J., 1970-
name: Tsang, Hector W. H.
name: Chan, Sunny H. W.
Publisher: name: BioMed Central
Year: 2022

description: Objectives This review investigates the efficacy and safety of non-invasive brain stimulation (NIBS) combined with psychosocial intervention on depressive symptoms. Materials and methods We systematically searched five electronic databases from their inception to June 2021: PubMed, Embase, PsycINFO, Web of Science, and Medline. Randomized or non-randomized clinical trials in which NIBS plus psychosocial intervention was compared to control conditions in people with depressive symptoms were included. Results A total of 17 eligible studies with 660 participants were included. The meta-analysis results showed that NIBS combined with psychosocial therapy had a positive effect on moderate to severe depression ([SMD = − 0.46, 95%CI (− 0.90, − 0.02), I2 = 73%, p < .01]), but did not significantly improve minimal to mild depression ([SMD = − 0.12, 95%CI (− 0.42, 0.18), I2 = 0%, p = .63]). Compared with NIBS alone, the combination treatment had a significantly greater effect in alleviating depressive symptoms ([SMD = − 0.84, 95%CI (− 1.25, − 0.42), I2 = 0%, p = .93]). However, our results suggested that the pooled effect size of ameliorating depression of NIBS plus psychosocial intervention had no significant difference compared with the combination of sham NIBS [SMD = − 0.12, 95%CI (− 0.31, 0.07), I2 = 0%, p = .60] and psychosocial intervention alone [SMD = − 0.97, 95%CI (− 2.32, 0.38), I2 = 72%, p = .01]. Conclusion NIBS when combined with psychosocial intervention has a significant positive effect in alleviating moderately to severely depressive symptoms. Further well-designed studies of NIBS combined with psychosocial intervention on depression should be carried out to consolidate the conclusions and explore the in-depth underlying mechanism.
Optimising Airport Security: Biometric Sorting by Departure Time
Creators: name: Naka, Khansa Kauthar Litty
Publisher: name: Swinburne
Year: 2024

description: This study adapts to post-pandemic airport operations, focusing on optimizing security through biometric sorting by departure time. It aims to understand dynamic passenger processes in future airport terminals influenced by demand and supply pressures. Conducted using Simio simulation, the research leverages key variables and real-time data from the Official Airline Guide (OAG) to enhance passenger processing. The model, based on Melbourne Airport, demonstrates that systematic security design can significantly improve efficiency, reduce wait times, and enhance customer satisfaction. Findings suggest that airport operators should implement biometric sorting by departure time to optimize security measures.
Η Κοινωνική Πολιτική στην Τοπική Αυτοδιοίκηση. Η περίπτωση του Δήμου Κορινθίων
Creators: name: Παπαθανασίου, Ελένη
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Τοπική αυτοδιοίκηση -- Ευρωπαϊκή Ένωση, Χώρες της
subject: Τοπική αυτοδιοίκηση -- Ελλάδα -- Περιπτωσιολογικές μελέτες
subject: Κοινωνική πολιτική -- Ευρωπαϊκή Ένωση, Χώρες της
subject: Κοινωνική πολιτική -- Ελλάδα -- Περιπτωσιολογικές μελέτες
subject: Κοινωνική πολιτική
subject: Τοπική αυτοδιοίκηση
subject: Ευρωπαϊκή Ένωση
subject: Δήμος Κορινθίων
subject: Social policy
subject: Local government
subject: European Union
subject: Municipality of Korinthos

description: Αριθμός Εισαγωγής: 013287 cd
description: Αντικείμενο της παρούσας διπλωματικής είναι η κοινωνική πολιτική που ασκείται από την τοπική αυτοδιοίκηση μέσα από τις μεταβολές που έγιναν σε τοπικό επίπεδο κατά τη διάρκεια των τελευταίων ετών. Εξετάζεται το πλαίσιο εντός του οποίου δραστηριοποιείται η τοπική αυτοδιοίκηση σε συνάρτηση με τις εθνικές αλλά και υπερεθνικές πολιτικές. Επιπλέον εξετάζεται η περίπτωση του Δήμου Κορινθίων και συγκεκριμένα ο τρόπος που ασκεί κοινωνική πολιτική ώστε να αναδειχθούν τα δυνατά και αδύνατα σημεία. Η παρούσα διπλωματική αποτελείται από δύο (2) μέρη. Το πρώτο μέρος είναι το θεωρητικό στο οποίο αναλύεται η έννοια της κοινωνικής πολιτικής, εξετάζεται η ιστορική εξέλιξη και ο ρόλος της τοπικής αυτοδιοίκησης στην άσκηση κοινωνικής πολιτικής. Επιπλέον γίνεται προσπάθεια να οριοθετηθεί ο ρόλος της στην Ελλάδα αλλά και στην Ευρώπη ως μηχανισμός παροχής υπηρεσιών κοινωνικού χαρακτήρα. Το δεύτερο μέρος είναι το εμπειρικό και εξετάζεται η περίπτωση του δήμου Κορινθίων, ως μηχανισμός άσκησης κοινωνικής πολιτικής. Γίνεται διερεύνηση και καταγραφή της οργανωτικής δομής της κοινωνικής υπηρεσίας καθώς και των προγραμμάτων που υλοποιεί. Στη συνέχεια ακολουθεί έρευνα που διεξήχθη κατόπιν επίσκεψής μου στις δομές τις κοινωνικής υπηρεσίας απευθυνόμενη στους υπαλλήλους και τα στελέχη της, οι οποίοι έλαβαν μέρος εθελοντικά. Συγκεκριμένα εξετάζεται κατά πόσο ο δήμος ανταποκρίνεται στις συνεχώς αυξανόμενες ανάγκες των πολιτών σε συνάρτηση με το αυστηρό δημοσιονομικό πλαίσιο το οποίο επιβάλει περιστολή δαπανών και αναστολή προσλήψεων. Η μεθοδολογία που ακολουθείται περιλαμβάνει βιβλιογραφική έρευνα, διαδικτυακή έρευνα και ποιοτική έρευνα με την χρήση ημιδομημένων συνεντεύξεων με υπαλλήλους και στελέχη του δήμου Κορινθίων.
A fast and strong microactuator powered by internal combustion of hydrogen and oxygen
Creators: name: Uvarov, Ilia
name: Shlepakov, Pavel
name: Svetovoy, Vitaly
Publisher: name: arXiv
Year: 2024
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: The development of fast and strong microactuators that can be integrated in microdevices is an essential challenge due to a lack of appropriate driving principles. In this paper, a membrane actuator powered by internal combustion of hydrogen and oxygen in a chamber with a volume of 3.1 nanoliters is demonstrated. The combustion in such a small volume is possible only for an extremely high surface-to-volume (S/V) ratio on the order of 10^7 1/m. The fuel with this S/V is prepared electrochemically in a special regime that produces only nanobubbles. A cloud of nanobubbles merges, forming a microbubble, which explodes, increasing the volume 500 times in 10us. The actuator generates an instantaneous force up to 0.5N and is able to move a body 11,000 times more massive than itself. The natural response time of about 10ms is defined by the incubation time needed to produce an exploding bubble. The device demonstrates reliable cyclic actuation at a frequency of 1Hz restricted by the effect of electrolyte aging. After 40,000 explosions, no significant wear in the chamber is observed. Due to record-breaking acceleration and standard microfabrication techniques, the actuator can be used as a universal engine for various microdevices including micro-electro-mechanical systems, microfluidics, microrobotics, wearable and implantable devices.
description: 28 pages,6 figures, 1 Video (ancillary), supplemental: 1 text file, 1 audio, 2 video
Supplementary document for High-performance broadband position-sensitive detector based on lateral photovoltaic effect of PbSe heterostructure - 5478279.pdf
Creators: name: Ma, Jikui
name: Chen, Mingjing
name: Qiao, Shuang
name: Fu, Guangsheng
name: Wang, Shufang
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental figures
Hebammenwahl - Wollishofer Blog
Creators: name: Brändli, Sebastian
Publisher: name: Zentralbibliothek Zürich
Year: 2024
Subjects: subject: 610 Medizin und Gesundheit
subject: 949 Geschichte anderer Teile Europas
subject: Zürich-Wollishofen
subject: Hebamme

description: Ein Blog zu Geschichte und Quartierleben des Zürcher Stadtquartiers Wollishofen auf wollipedia.ch. Mit Texten von Sebastian Brändli (SB) und Ansichtskarten aus der Sammlung von Markus Zimmermann (MZ).
Cross-cultural Perspectives on Forensic Risk Assessment
Creators: name: Venner, Samantha Louise
Publisher: name: Swinburne
Year: 2024

description: Risk assessment tools are used in forensic settings to estimate risk of reoffending, however a growing body of research has queried whether these tools are appropriate for use cross-culturally. This thesis examined the appropriateness of a widely used risk tool (the LS/RNR) for use with Aboriginal and Torres Strait Islander, African Australian, Pacific Islander and Maori people. Findings suggest that the LS/RNR may not incorporate all relevant risk and protective factors for members of these cultural groups, however further research is required to determine if cultural considerations are best considered as relevant to risk prediction, or to treatment and management.
Η διοίκηση ανθρώπινου δυναμικού ως παράγοντας αύξησης της αποδοτικότητας των εργαζομένων
Creators: name: Ζαρκανιώτη, Χαρά
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Διοίκηση ανθρώπινου δυναμικού
subject: Ανθρώπινοι πόροι
subject: Αποδοτικότητα εργαζομένων
subject: Παρακίνηση

description: Οι ολοένα μεταβαλλόμενες συνθήκες υποχρέωσαν τις επιχειρήσεις και τους οργανισμούς να στραφούν σε αποτελεσματικότερες μεθόδους αύξησης της αποδοτικότητας τους. Ειδικότερα, η ανάγκη για ανταγωνιστικότητα, ώθησε τις επιχειρήσεις να ενεργοποιήσουν την αποτελεσματική διαχείριση του ανθρώπινου δυναμικού, καθώς πρόκειται για την κινητήρια δύναμη μιας επιχείρησης. Συνεπώς, η διοίκηση ανθρώπινου δυναμικού διαδραματίζει σημαντικό ρόλο στη συνολική στρατηγική ανάπτυξης της επιχείρησης και οι δραστηριότητες της βοηθούν καθοριστικά στην επίτευξη των στόχων της επιχείρησης, καθώς και στην απόκτηση και διατήρηση ανταγωνιστικού πλεονεκτήματος. Απώτερο σκοπό της παρούσας διπλωματικής εργασίας αποτελεί το κατά πόσο συμβάλλει η διοίκηση ανθρώπινου δυναμικού στην αύξηση της αποδοτικότητας των εργαζομένων. Αρχικά, παρουσιάζεται η ιστορική εξέλιξη και η σημασία της, καθώς και ποιος είναι ο ρόλος της, οι στόχοι της και οι αρμοδιότητες της. Στη συνέχεια, γίνεται αναφορά στο ανθρώπινο δυναμικό και στους παράγοντες υποκίνησης. Τέλος, πραγματοποιείται ποσοτική έρευνα, με τη χρήση ερωτηματολογίου, το οποίο διανεμήθηκε και απαντήθηκε από τους υπαλλήλους της επιχείρησης Καρβελάς ΑΒΕΕ με στόχο να αναλυθούν τα κίνητρα τα οποία ωθούν τους εργαζομένους στη βελτίωση της αποδοτικότητας τους. Ευελπιστώ, η εν λόγω προσπάθεια να φανεί χρήσιμη στον αναγνώστη που επιθυμεί να κατανοήσει το βαθμό συμβολής της διοίκησης ανθρώπινου δυναμικού στους εργαζομένους της.
Galactic-Field Metal-Rich RR~Lyrae Variables: Features of Kinematics and Abundances of Selected Chemical Elements
Creators: name: Gozha, M. L.
name: Marsakov, V. A.
name: Koval', V. V.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an analysis of the relative abundance features of a number of chemical elements in the atmospheres of metal-rich ($\rm{[Fe/H]} > -1.0$) Galactic-field RR~Lyrae variable stars and the kinematic characteristics of these stars. We have previously shown that the relative abundances of some $α$-elements: magnesium, silicon, calcium, and to a greater extent of titanium, as well as yttrium and scandium in such stars are lower than in most of other types of stars, bearing similar metallicity. It is found here that some of these metal-rich RR~Lyrae stars also have very low relative abundances of sodium, aluminum and nickel. The orbital parameters of all the metal-rich RR~Lyrae variables studied in this paper are typical of the Galactic thin or thick disk objects, however, unusual chemical composition let us to suggests a possible extragalactic origin for some of them.
description: 19 pages, 3 figures, 2 tables
Assessment of Coilia mystus and C. nasus in the Yangtze River Estuary, China, Using a Length-Based Approach
Creators: name: Zhai, Lu
name: Li, Zengguang
name: Hu, Yongbin
name: Huang, Chengwei
name: Tian, Siquan
name: Wan, Rong
name: Pauly, D. (Daniel)
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: An assessment of the stock status and historical changes in abundance of Coilia mystus and C. nasus in the Yangtze River Estuary, China, was carried out based on field surveys conducted in 2019–2020 and published length-frequency (L/F) data from earlier periods. These two species’ current and past relative biomasses (B/BMSY) were estimated using a length-based Bayesian biomass estimation method (LBB). The LLB method also estimated their asymptotic lengths (Linf), current and optimum mean lengths at first capture (Lc; Lopt_c), and their ratios of natural and fishing mortality to growth (M/K; F/K). In response to increasing fishing pressure, both species’ maximum lengths declined, along with their B/BMSY ratio, which declined for C. mystus from 1.7 in 1982 to 0.47 in 2020 and for C. nasus from 1.7 in 2006 (or earlier) to 0.17 in 2020. These assessments show that both of the two Coilia species are overfished, with C. nasus impacted more severely than C. mystus. The prospect for the recovery of these two species is briefly discussed. This contribution will help toward the management of the population of these two Coilia species and provides a basis for evaluating the effect of the 10-year fishing ban in the Yangtze River.
title: Αξιολόγηση τεχνολογιών αυθεντικοποίησης με χρήση σάρωσης προσώπου και ταυτοποιητικού εγγράφου
title: Assessment of authentication technologies using face scanning and document id
titleType: AlternativeTitle
Creators: name: Κασώτης, Δημήτριος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: 3D Liveness
subject: FaceTec
subject: Android

description: Η επαλήθευση ταυτότητας είναι απαραίτητη σε διάφορες πτυχές τις καθημερινότητας. Για αυτό το λόγο υπάρχει πληθώρα εφαρμογών όπου ενδεικτικά κυμαίνονται από το ξεκλείδωμα της κινητής συσκευής έως την πρόσβαση σε ηλεκτρονικό λογαριασμό. Εναλλακτικά μπορεί να έχει εφαρμογή στην καταγραφή των χρόνων άφιξης και εξόδου από την εργασία ή τον έλεγχο της πρόσβασης σε περιορισμένη περιοχή. Η δημοφιλέστερη εκδοχή επαλήθευσης ταυτότητας είναι ο έλεγχος ταυτότητας με κωδικό πρόσβασης. Ωστόσο ο συγκεκριμένος τρόπος παρουσιάζει δυσκολίες οι οποίες χάριν παραδείγματος αφορούν σε ξεχασμένο ή κλεμμένο κωδικό πρόσβασης ή πολυπλοκότητα στη διαδικασία που δυσκολεύει τον εκάστοτε χρήστη. Η παρούσα μεταπτυχιακή διατριβή παρουσιάζει μια εναλλακτική λύση η οποία έχει εφαρμογή σε κινητά τηλέφωνα τεχνολογίας Android και μπορεί να αποτελέσει βελτίωση στις υπάρχουσες μεθόδους επαλήθευσης ταυτότητας. Αυτή η βελτιωμένη επαλήθευση ταυτότητας είναι μια προσέγγιση μέσω του SDK που παρέχει η FaceTec. Η εφαρμογή αποτελεί ένα συστήματα αυθεντικοποίησης που έχει ως προϋπόθεση ότι ο χρήστης έχει μια ταυτότητα την οποία καλείται να επαληθεύσει με έλεγχο προσώπου ή πληκτρολόγηση ενός username και password. Τα χαρακτηριστικά και οι ενέργειες του προσώπου του χρήστη πρέπει να ταιριάζουν με αυτά που έχουν αποθηκευτεί στο σύστημα για να περάσουν την επαλήθευση ταυτότητας. Η επαλήθευση απαιτεί την μετωπική όψη του προσώπου και επικυρώνει ταυτόχρονα τα χαρακτηριστικά και τις ενέργειες του προσώπου. Στην ουσία δημιουργεί μια ενσωμάτωση των χαρακτηριστικών και της δράσης του προσώπου σε ένα σύντομο βίντεο για αντιστοίχιση. Με λίγα λόγια, ο χρήστης με μία βίντεο-selfie επαληθεύει το 3D liveness. Η εφαρμογή συγκρίνει το πρόσωπο του μέσω της φωτογραφίας του στο δίπλωμα, πραγματοποιείται οπτική αναγνώριση κειμένου του διπλώματος και επαληθεύει τα στοιχεία του. Εφόσον ο χρήστης ανοίξει εκ νέου την εφαρμογή ο έλεγχος ταυτότητας προσώπου αποδεικνύει και πάλι το 3D liveness το οποίο συγκρίνεται με το ήδη καταχωρημένο 3D Face Map και πραγματοποιεί είσοδο στην εφαρμογή χωρίς να απαιτείται κωδικός πρόσβασης.
USING K-MEANS CLUSTER AND FUZZY C MEANS FOR DEFECT SEGMENTATION IN FRUITS
Creators: name: DS, Vinod
name: Ashok, Vani
Publisher: name: figshare
Year: 2022
Subjects: Computer Engineering

description: Vani Ashok and D.S.Vinod, Using K-means Cluster and Fuzzy C Means for Defect Segmentation in Fruits, 2 nd International Conference on Current Trends in Engineering and Management (ICCTEM-2014), Page 1213 to 1219 held in Vidyavardhaka College of Engineering, Mysore, India on 17 th to 19 th of July 2014. Organised by Vidyavardhaka College of Engineering, Mysore, India.
Construction of Tm-type and Tm-assisted PBIB designs
Creators: name: Kaur, Parneet
name: Kumar Garg, Davinder
Publisher: name: REVSTAT-Statistical Journal
Year: 2022

description: Two-associate class triangular designs have been explored greatly but the Tm-type PBIB designs (m ≥ 3) largely remains unexplored. The paper is written with an objective to construct a new series of Tm-type PBIB designs and to derive some more series of PBIB designs based on these PBIB designs, which we have called as Tm-assisted PBIB designs. For this, we begin by first constructing a series of Tm-type PBIB designs and then based on these designs, three series of Tm-assisted PBIB designs have been constructed. The association schemes of Tm-type and Tm-assisted PBIB designs have been discussed in their complete generalized form.
description: REVSTAT-Statistical Journal, Vol. 20 No. 2 (2022): REVSTAT-Statistical Journal
Lisbon Computational Linguists at SemEval-2024 Task 2: Using A Mistral 7B Model and Data Augmentation
Creators: name: Guimarães, Artur
name: Martins, Bruno
name: Magalhães, João
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7

description: This paper describes our approach to the SemEval-2024 safe biomedical Natural Language Inference for Clinical Trials (NLI4CT) task, which concerns classifying statements about Clinical Trial Reports (CTRs). We explored the capabilities of Mistral-7B, a generalist open-source Large Language Model (LLM). We developed a prompt for the NLI4CT task, and fine-tuned a quantized version of the model using an augmented version of the training dataset. The experimental results show that this approach can produce notable results in terms of the macro F1-score, while having limitations in terms of faithfulness and consistency. All the developed code is publicly available on a GitHub repository
description: 8 pages, 1 figure, submitted and accepted into the "18th International Workshop on Semantic Evaluation (SemEval-2024)"
Additional file 1 of The course of primary progressive aphasia diagnosis: a cross-sectional study
Creators: name: Mouton, A.
name: Plonka, A.
name: Fabre, R.
name: Tran, T. M.
name: Robert, P.
name: Macoir, J.
name: Manera, V.
name: Gros, A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1: Table S1. Comparison of descriptive characteristics of the AD vs PPA groups (Bayesian analyses). Table S2. Number of different diagnoses before and after first consultation.
Evolution of Star Cluster Within Galaxy using Self-consistent Hybrid Hydro/N-body Simulation
Creators: name: Jo, Yongseok
name: Kim, Seoyoung
name: Kim, Ji-hoon
name: Bryan, Greg L.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We introduce a GPU-accelerated hybrid hydro/N-body code (Enzo-N) designed to address the challenges of concurrently simulating star clusters and their parent galaxies. This task has been exceedingly challenging, primarily due to the considerable computational time required, which stems from the substantial scale difference between galaxies (~ 0.1 Mpc) and star clusters (~ pc). Yet, this significant scale separation means that particles within star clusters perceive those outside the star cluster in a semi-stationary state. By leveraging this aspect, we integrate the direct N-body code (Nbody6++GPU) into the cosmological (magneto-)hydrodynamic code (Enzo) through the utilization of the semi-stationary background acceleration approximation. We solve the dynamics of particles within star clusters using the direct N-body solver with regularization for few-body interactions, while evolving particles outside -- dark matter, gas, and stars -- using the particle-mesh gravity solver and hydrodynamic methods. We demonstrate that Enzo-N successfully simulates the co-evolution of star clusters and their parent galaxies, capturing phenomena such as core collapse of the star cluster and tidal stripping due to galactic tides. This comprehensive framework opens up new possibilities for studying the evolution of star clusters within galaxies, offering insights that were previously inaccessible.
description: 15 pages, 13 figures, Accepted for publication in ApJ
Workshop "Vulnerabilität im Kontext von Umwelt und Gesundheit"
Creators: name: Conrad, André
name: Meierrose. Judith
name: Obermüller, Svenja
name: Steinkühler, Nadja
Publisher: name: My University
Year: 2017

description: Antibiotikaresistenzen sind ein gravierendes Problem für Umwelt und Gesundheit. Ausgabe 02/2017 der Zeitschrift UMID stellt in einem Schwerpunkt aktuelle Diskussionen zu Resistenzen in der Umwelt vor. Weitere Beiträge informieren, wie Resistenzen im Bereich der Lebensmittelkette und im Bereich der Humanmedizin überwacht werden. Einen weiteren Schwerpunkt im Heft bildet das Thema Vulnerabilität im Kontext Umwelt und Gesundheit. Vorgestellt werden aktuelle Diskussionen eines Workshops zu diesem Thema. Erörtert wurden dort unter anderem Definitionen des Begriffs Vulnerabilität und verschiedene Einzelfragen wie etwa Vulnerabilität im Zusammenhang mit Verkehrslärm. Außerdem informiert die neue Ausgabe über die Hintergründe der Festsetzung von Grenzwerten für Stickstoffdioxid in der EU, die Planungen der EU hinsichtlich der Wiederverwendung von behandeltem Abwasser und widmet sich in weiteren Beiträgen dem demographischen Wandel und gesundem Altern in Deutschland. Quelle: https://www.umweltbundesamt.de/
Data management and data analysis in the large European projects GEHA (GEnetics of Healthy Aging) and NU-AGE (NUtrition and AGEing): a bioinformatic approach
Creators: name: Vianello, Dario <1987>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/04 Patologia generale

description: The aging process is characterized by the progressive fitness decline experienced at all the levels of physiological organization, from single molecules up to the whole organism. Studies confirmed inflammaging, a chronic low-level inflammation, as a deeply intertwined partner of the aging process, which may provide the “common soil” upon which age-related diseases develop and flourish. Thus, albeit inflammation per se represents a physiological process, it can rapidly become detrimental if it goes out of control causing an excess of local and systemic inflammatory response, a striking risk factor for the elderly population. Developing interventions to counteract the establishment of this state is thus a top priority. Diet, among other factors, represents a good candidate to regulate inflammation. Building on top of this consideration, the EU project NU-AGE is now trying to assess if a Mediterranean diet, fortified for the elderly population needs, may help in modulating inflammaging. To do so, NU-AGE enrolled a total of 1250 subjects, half of which followed a 1-year long diet, and characterized them by mean of the most advanced –omics and non –omics analyses. The aim of this thesis was the development of a solid data management pipeline able to efficiently cope with the results of these assays, which are now flowing inside a centralized database, ready to be used to test the most disparate scientific hypotheses. At the same time, the work hereby described encompasses the data analysis of the GEHA project, which was focused on identifying the genetic determinants of longevity, with a particular focus on developing and applying a method for detecting epistatic interactions in human mtDNA. Eventually, in an effort to propel the adoption of NGS technologies in everyday pipeline, we developed a NGS variant calling pipeline devoted to solve all the sequencing-related issues of the mtDNA.
Additional file 1 of The development and implementation of a guideline-based clinical decision support system to improve empirical antibiotic prescribing
Creators: name: Akhloufi, H.
name: van der Sijs, H.
name: Melles, D. C.
name: van der Hoeven, C. P.
name: Vogel, M.
name: Mouton, J. W.
name: Verbon, A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Additional file 1. The resistance viewer in the CDSS for empirical antibiotic therapy.
Epigenetic signature in persons with Down Syndrome
Creators: name: Fontanesi, Elisa <1984>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/04 Patologia generale

description: Persons affected by Down Syndrome show a heterogeneous phenotype that includes developmental defects and cognitive and haematological disorders. Premature accelerated aging and the consequent development of age associated diseases like Alzheimer Disease (AD) seem to be the cause of higher mortality late in life of DS persons.
Down Syndrome is caused by the complete or partial trisomy of chromosome 21, but it is not clear if the molecular alterations of the disease are triggered by the specific functions of a limited number of genes on chromosome 21 or by the disruption of genetic homeostasis due the presence of a trisomic chromosome. As epigenomic studies can help to shed light on this issue, here we used the Infinium HumanMethilation450 BeadChip to analyse blood DNA methylation patterns of 29 persons affected by Down syndrome (DSP), using their healthy siblings (DSS) and mothers (DSM) as controls. In this way we obtained a family-based model that allowed us to monitor possible confounding effects on DNA methylation patterns deriving from genetic and environmental factors.
We showed that defects in DNA methylation map in genes involved in developmental, neurological and haematological pathways. These genes are enriched on chromosome 21 but localize also in the rest of the genome, suggesting that the trisomy of specific genes on chromosome 21 induces a cascade of events that engages many genes on other chromosomes and results in a global alteration of genomic function. We also analysed the methylation status of three target regions localized at the promoter (Ribo) and at the 5’ sequences of 18S and 28S regions of the rDNA, identifying differently methylated CpG sites.
In conclusion, we identified an epigenetic signature of Down Syndrome in blood cells that sustains a link between developmental defects and disease phenotype, including segmental premature aging.