cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Biology and Interplay of Immunotherapy by Leukemia-Oncolytic Virus (iLOV) Immune Responses
Creators: name: Tsang, Jovian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: subject: Oncolytic virus
subject: Cancer immunotherapy
subject: Humoral immunity
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer therapy
subject: Acute lymphoblastic leukemia

description: Oncolytic viruses (OVs) are novel biological agents that selectively infect and kill malignant cells. OVs can also generate anti-cancer immunity. Our lab exploited this phenomenon and developed an in vitro vaccine with infected leukemia cells with oncolytic virus vaccine – and named immunotherapy by leukemia-oncolytic virus (iLOV) – that provided in vivo protection in a murine model for acute lymphoblastic leukemia. This work further characterizes iLOV biology and the interaction of its immune responses. An in vitro immune response assay was optimized to detect and quantify the in vivo anti-leukemia immunity generated by iLOV. Anti-viral immunity is an obstacle for OV therapy. Although iLOV created anti-viral antibodies towards itself, these neutralizing antibodies did not hinder the vaccine’s ability to initiate complement or dendritic cell activation. We envision personalized versions of iLOV for leukemia patients in remission to prevent the possibility of relapse. This work highlights new advantages for infected cell vaccines and supports the progress of iLOV toward clinical testing.
Revamping the economics curriculum
Creators: name: Harkness, Peter
Publisher: name: Swinburne
Year: 2024

description: Economics is commonly studied at schools and is one of the most popular courses at university (usually within a Bachelor of Business or Commerce degree). Thus, it is of great importance that the economics curriculum is enlightening and revealing and addresses profound questions. In my view, it is not doing this well. The typical syllabus hides more than it reveals, especially at the tertiary level. This paper will describe the major deficiencies in the way economics is normally taught in western countries, including how narrow and unrealistic orthodox economic theory is, and how it legitimises our unequal, competitive, individualistic capitalistic economic system. Orthodox economics courses rarely question the status quo, and rarely present students with alternative ways of imagining society. The paper outlines an alternative syllabus which endeavours to analyse the economy the way it really is, and addresses all its main dimensions: historical, social, political and environmental. This contrasts starkly with the simplistic stylised 'perfectly competitive' economy assumed in standard economic theory.
Registries for orphan drugs: generating evidence or marketing tools?
Creators: name: Hollak, Carla E M
name: Sirrs, Sandra
name: Van Den Berg, Sibren
name: Van Der Wel, Vincent
name: Langeveld, Mirjam
name: Dekker, Hanka
name: Lachmann, Robin
name: De Visser, Saco J
Publisher: name: BioMed Central
Year: 2020

description: Independent disease registries for pre-and post-approval of novel treatments for rare diseases are increasingly important for healthcare professionals, patients, regulators and the pharmaceutical industry. Current registries for rare diseases to evaluate orphan drugs are mainly set up and owned by the pharmaceutical industry which leads to unacceptable conflicts of interest. To ensure independence from commercial interests, disease registries should be set up and maintained by healthcare professionals and patients. Public funding should be directed towards an early establishment of international registries for orphan diseases, ideally well before novel treatments are introduced. Regulatory bodies should insist on the use of data from independent disease registries rather than company driven, drug-oriented registries.
Rhabdovirotherapy Reduces the Risk of Metastatic Disease After Cancer Surgery by Enhancing Natural Killer Cell Function
Creators: name: Zhang, Jiqing
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: MG1
Natural killer cell
surgery
cancer metastasis

description: In the present study, we characterized the ability of a novel oncolytic rhabdovirus - Maraba MG1 to boost Natural Killer (NK) cell activity. In tandem, we addressed the ability of this enhanced NK cell functionality to reduce the incidence of post-cancer surgery micrometastases. Due to the potential safety barriers associated with the use of a live virus immediately prior to surgery in cancer patients, we generated a single cycle replication virus (MG1-Gless) and UV-inactivated MG1 to stimulate NK cell function and reduce post-operative metastases. Our in vivo data demonstrate that significant NK cell activation and a similar level of reduction in postoperative tumor metastases was achieved with live MG1, MG1-Gless and UV-inactivated MG1, concluding that viral replication is important, but not necessary for NK cell activation. Mechanistically, we observed that dendritic cells (DCs) are necessary intermediates for MG1-induced NK cell activation. Finally, we characterized and compared a panel of UV-inactivated MG1 (2mins to 2hrs) to better understand the requirements for NK cell activation. Our results suggest that intact viral particle and cellular recognition and association are essential for NK cell mediated anti-tumor responses. These findings provide the preclinical rationale to develop safe and viable virotherapy-based interventional protocols that might reduce the risk of metastatic disease after cancer surgery.
Becoming Evangelical in Rural Costa Rica: A Study of Religious Conversion and Evangelical Faith and Practice
Creators: name: Epp, Jared M.H.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Pentecostalism
Religious Conversion
Latin America
Religious Experience
Evangelical Christianity
Anthropology of Religion

description: Almost daily emotional worship pours from a warehouse-sized evangelical church in the small rural community of Santa Cruz, Costa Rica. Within twenty years an evangelical presence has gone from virtually non-existent to standing alongside the Catholic Church in the area’s religious landscape. Scenarios like this are going on throughout Latin America as evangelical faith has become firmly rooted in the region. In this thesis I provide another ethnographic research context to the growing body of literature focused on Pentecostalism/evangelicalism in Latin America. Like others addressing this dynamic, I explore the factors and motivations that lead people to become evangelical. I approach these questions with particular emphasis on the characteristics of evangelical faith as it is constructed and practiced during church services. Through participant observation during church services and interviews with practicing evangelicals in and around Santa Cruz, I highlight the relationship between the characteristics of an evangelical faith and the factors and motivations that lead people to seek it. To be religiously active in the manner of my informants requires deep commitment and is not a faith adopted and practiced lightly. Those who become evangelical and sustain the demanding practice are likely to seek it for spiritual solutions to difficult life situations.
KOSMOSNI XALQARO VA MILLIY NUQTAI NAZARDAN TARTIBGA SOLISH MASALALARI, MUAMMOLAR VA ISTIQBOL
Creators: name: Ochilov, Asliddin
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada xalqaro kosmik huquqning asoslari va uning O'zbekiston qonunchilik kontekstida qo'llanilishi ko'rib chiqiladi. IMRAD (Kirish, Metodlar, Natijalar va Muhokama) tuzilmasidan foydalanish orqali biz xalqaro kosmik huquqning keng qamrovli koʻrinishini taqdim etamiz, Oʻzbekistonning ushbu sohadagi qonunchilik choralarini tahlil qilamiz va milliy meʼyoriy hujjatlarni jahon standartlariga moslashtirish boʻyicha tushunchalarni taklif etamiz. Tadqiqotda Oʻzbekistondagi kosmik qonunchiligining hozirgi holati va kelajak istiqbollarini koʻrsatish uchun shartnomalar, milliy qonunlar va statistik maʼlumotlardan iborat turli manbalardan foydalaniladi.
Video Streaming in Vehicular Ad Hoc Networks: Challenges, Protocols and The Use of Redundancy
Creators: name: Rezende, Cristiano
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Vehicular Ad Hoc Networks
VANETs
Video Streaming

description: Vehicular Ad Hoc Networks (VANETs) are no longer a futuristic promise but rather an attainable technology. Vehicles are already equipped with a variety of computational devices that control or assist drivers in many tasks such as localization, safely breaking, parking and passengers entertainment. The majority of services envisioned for VANETs either require the provision of multimedia support or have it as an extremely beneficial additional feature. In particular, video streaming capabilities over VANETs are crucial to the development of interesting and valuable services. However,VANETs’ highly dynamic topology poses as a demanding challenge to the fulfillment of video streaming’s stringent requirements. The main goal on this thesis is the development of feasible solutions that support the streaming of video content over VANETs. Initially, the main issues of VANETs are explained through both a discussion of its characteristics and the results of some preliminary conclusions. Based on this understanding of VANETs’ peculiarities, three distinguishing solutions are designed REACT-DIS, REDEC and VIRTUS; the two first for video dissemination and the later for video unicast. These solutions offer a great advancement towards the provision of video streaming capabilities but packet loss is still an issue at high data rates. In order to improve the delivery ratios reached by the previous solutions, redundancy is used as an error correction mechanism. The use of redundancy is ideal for VANETs in handling packet loss as they do not require any interaction between source and receivers nodes. Sophisticated coding techniques were used for an efficient use of the increase on entropy of the information sent by the source node. It was also evaluated the selective use of redundancy solely on packets carrying the crucial information of I-frames. Although this selective approach obtained lower overall delivery ratios than when redundancy is used for all packets, the video quality obtained similar improvements under a much lower cost. The evaluation on the use of redundancy has considered the impact on the rate by which unique video content is received at end-users which is fundamental to understand the resolution of videos that can be displayed. This thesis provides several contributions as it advances the knowledge in the peculiarities of VANETs, solutions for video streaming over VANETs and the use of redundancy as an error correction mechanism for video streaming over VANETs.
CO2 Capture from Dilute Sources via Lime-Based Sorbents
Creators: name: Samari, Mohammad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Direct Air Capture
Lime-Based Sorbents

description: Direct capture of CO2 from ambient air is a developing technology, which is capable of removing CO2 directly from the atmosphere. Moreover, this technology is independent from sources of CO2 emissions. Hence, it can be set up at locations where pure stream of CO2 is needed such as in enhanced oil recovery. In this research, the performance of pelletized and natural limestone for CO2 capture from air in a fixed bed is studied. To compare the performance of sorbents for air capture, the effects of particle type (natural limestone and pelletized limestone), particle size (250-425 µm and 425-600 µm), gas flowrate (0.5 L/min and 1 L/min), and relative humidity, on the breakthrough time, breakthrough shape, and the global reaction rate are examined. Moreover, carbonation decay of sorbents over series of capture and regeneration cycles is studied. If the inlet stream (air) is humidified at 50% relative humidity, but the lime sorbents are not pre-hydrated, an axially non-uniform carbonated bed results. This phenomenon is due to the partial carbonation of sorbents at the first layers of the bed. While there is a competition between CO2 and water to react with CaO, partial carbonation reaction on the surface of the sorbents not only prevents further hydration, but also decreases the reaction rate at the surface. However, in comparison with a dry system where relative humidity was negligible and sorbents were not pre-hydrated, the observed carbonation conversion was higher. The best results were seen from experiments with pre-hydrated sorbents and humidified inlet stream. The smaller sorbent particles had a better performance (sharper breakthrough curve and longer breakthrough time) due to their greater surface area. A gas-solid reaction model was fitted to the breakthrough curves. Since at the beginning of carbonation there is no resistance of the product layer, it can be assumed that the process is reaction controlled. While after formation of the product layer (CaCO3), it becomes diffusion controlled. Results from fitted data also confirmed these conclusions. Moreover, each of sorbent went through 9 cycles and after each cycle the carbonation conversion of the sorbents was measured by TGA and the surface area by BET.
Additional file 13 of Genome-wide detection of signatures of selection in indicine and Brazilian locally adapted taurine cattle breeds using whole-genome re-sequencing data
Creators: name: Peripolli, Elisa
name: Reimer, Christian
name: Ngoc-Thuy Ha
name: Geibel, Johannes
name: Machado, Marco Antonio
name: Panetto, João Cláudio Do Carmo
name: Egito, Andréa Alves Do
name: Baldi, Fernando
name: Simianer, Henner
name: Silva, Marcos Vinícius Gualberto Barbosa Da
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 13. Manhattan plot of the independent results for each selective sweep statistical method and population.
Seismic fragility curves for soft-storey buildings
Creators: name: Rodsin, Kittipoom
name: Lam, Nelson T. K.
name: Wilson, John
name: Goldsworthy, Helen
Publisher: name: Swinburne
Year: 2024

description: Buildings with a soft-storey are notoriously vulnerable to collapse under strong earthquake shaking. However, a building subject to a small or moderate magnitude earthquake has a fair chance of survival depending on the drift demand on the softstorey. This paper presents fragility curves which define the probability of collapse of a soft-storey column when subject to a pre-defined drift demand. The calculation for the fragility curves is based on the estimated shear (frictional) resistance to slip along a major diagonal shear crack (which is the plane of weakness for collapse to occur). The fragility curves presented can be shown to provide a more realistic representation of the seismic vulnerability of the building than the conventional approach based simply on the degradation in the horizontal resistance of the column.
Lateral Facies Trends in Deep-Marine Slope and Basin Floor Matrix-Rich Beds, Neoproterozoic Windermere Supergroup, British Columbia, Canada
Creators: name: Angus, Katrina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: matrix-rich sandstones
particle settling
bipartite beds
avulsion
slope
proximal basin floor

description: This study investigates the lithological characteristics, and lateral and vertical facies trends of poorly understood, deep-marine matrix-rich sedimentary rocks. Two laterally extensive, well-exposed outcrops of slope and proximal basin floor deposits were investigated from the Neoproterozoic Windermere Supergroup. Significantly, matrix-rich beds have been found to undergo the same lateral trends (over ~200-650 m) in both outcrops. Initially, thicker, clayey sandstone transitions laterally to a bipartite bed with the development of an upper, planar-based, more matrix-rich unit. Further laterally, the basal unit progressively thins until it pinches out, and all that remains is the upper, more matrix-rich unit – a sandy claystone. It too thins and then pinches out. Draping the entire transect is a thin, matrix-poor structured unit overlain by a mudstone or claystone cap. These trends are interpreted to reflect a progressive but rapid lateral evolution of flow structure controlled primarily by particle settling, namely sand, from mud-rich avulsion-related flows.
Stability of serum precipitins to Aspergillus fumigatus for the diagnosis of allergic bronchopulmonary aspergillosis
Creators: name: Lau, Kevin Soon-Keen
name: Yeung, Chantane
name: Carlsten, Christopher Russell
Publisher: name: BioMed Central
Year: 2020

description: Background: Allergic bronchopulmonary aspergillosis (ABPA) reflects hypersensitivity and an exaggerated immune response to Aspergillus fumigatus. ABPA typically occurs in individuals with airway diseases such as asthma or cystic fibrosis and is associated with worse outcomes for individuals with these conditions. Each year, physicians across the province of British Columbia submit over 2600 diagnostic testing requests to a centralized location in Vancouver, requiring specimen collection, storage, and shipment from different clinics across the province. Timely and reliable testing of Aspergillus precipitins is critical to optimizing diagnosis and management of ABPA. At our centre, we analyzed sample stability in varying storage conditions to provide guidance to those using this routine diagnostic test. Methods: To determine temperature and time stability, 31 serum specimens positive for Aspergillus fumigatus precipitins from routine clinical testing were each aliquoted and incubated at 4 and 37 °C. Samples were repeatedly assayed for precipitins to Aspergillus fumigatus via agarose gel double immunodiffusion (AGID) at 7, 14, and 28 days post-incubation. To determine freeze–thaw stability, 39 serum specimens submitted for routine clinical testing for Aspergillus precipitins were randomly selected. Each specimen was aliquoted and stored at 4 or −20 °C. 4 °C samples were maintained at 4 °C while −20 °C samples were split into three groups corresponding to one, two, or three freeze–thaw cycles. −20 °C samples were thawed at room temperature in the morning and then immediately frozen overnight for up to a total of three freeze–thaw cycles. Results: Regarding temperature and time stability, median stability time was 47 and 34 days at 4 and 37 °C, respectively. The log-rank model indicates no statistically significant difference between the two temperature storage conditions (p = 0.14) with a hazard ratio of 0.61 (95% CI, 0.31–1.2). In terms of freeze–thaw stability, no indication of serum degradation with regards to Aspergillus fumigatus precipitins was found with repeated freeze–thaw cycles as compared to refrigerated storage. Conclusions: The stability of serum precipitins to Aspergillus fumigatus was found to be dependent on time, but not temperature and freeze–thaw cycles. Specimens for Aspergillus fumigatus precipitins testing should be shipped at ambient temperature and tested within 2 weeks from collection.
Preparation and Characterization of Kaolinite-based Nanocomposite Materials
Creators: name: Czarnecka, Anna
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: clay
kaolinite
nanocomposite
nylon 6
sarcosine
6-aminohexanoic acid (AHA)

description: A kaolinite-nylon 6 composite was prepared by a polycondensation reaction from 6-aminohexanoic acid (AHA) intercalated in the kaolinite interlayer space. The basal spacing of kaolinite-AHA was 1.47 nm and the basal spacing of the heated products decreased to 1.16 nm. The signals attributed to nylon 6 were detected in the 13C CP/MAS NMR spectra of the heated products. Formation of nylon 6 in kaolinite was confirmed by appearance of IR band due to amide I and amide II. Sarcosine was intercalated in kaolinite for the first time by guest displacement with methanol from the kaolinite-methanol precursor. The basal spacing of kaolinite-sarcosine was 1.27 nm. This intercalation compound was characterized by NMR, TGA, XRD, and IR. The physical and chemical properties of natural clay sample from Mirandela formation (Portugal) were determined in terms of external skin treatment. The low CEC 4,45meq/100g is consistent with high content of kaolinite in the sample
Supplementary document for Direct acceleration of collimated monoenergetic attosecond electron bunches driven by a radially polarized laser pulse - 5402391.pdf
Creators: name: Yue, Cao
name: Hu, Li-Xiang
name: Yan-Ting, Hu
name: Zhao, Jie
name: Debin, Zou
name: Xiao-Hu, Yang
name: ZHANG, FANGPEI
name: Shao, F Q
name: Yu, Tong-Pu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Plasma Physics

description: Supplemental Document
Characterization of the Protein Lysine Methyltransferase SMYD2
Creators: name: Lanouette, Sylvain
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Lysine Methylation
Post-Translational Modifications
SMYD2
SET Methyltransferase
SMYD
HSP90
Myogenic Differentiation
Computational Protein Design
Multi-State Design
SIX1
SIX2
DHX15
SIN3

description: Our understanding of protein lysine methyltransferases and their substrates remains limited despite their importance as regulators of the proteome. The SMYD (SET and MYND domain) methyltransferase family plays pivotal roles in various cellular processes, including transcriptional regulation and embryonic development. Among them, SMYD2 is associated with oesophageal squamous cell carcinoma, bladder cancer and leukemia as well as with embryonic development. Initially identified as a histone methyltransferase, SMYD2 was later reported to methylate p53, the retinoblastoma protein pRb and the estrogen receptor ERalpha and to regulate their activity. Our proteomic and biochemical analyses demonstrated that SMYD2 also methylates the molecular chaperone HSP90 on K209 and K615. We also showed that HSP90 methylation is regulated by HSP90 co-chaperones, pH, and the demethylase LSD1. Further methyltransferase assays demonstrated that SMYD2 methylates lysine K* in proteins which include the sequence [LFM]-₁-K*-[AFYMSHRK]+₁-[LYK]+₂. This motif allowed us to show that SMYD2 methylates the transcriptional co-repressor SIN3B, the RNA helicase DHX15 and the myogenic transcription factors SIX1 and SIX2. Finally, muscle cell models suggest that SMYD2 methyltransferase activity plays a role in preventing premature myogenic differentiation of proliferating myoblasts by repressing muscle-specific genes. Our work thus shows that SMYD2 methyltransferase activity targets a broad array of substrates in vitro and in situ and is regulated by intricate mechanisms.
Additional file 4 of Genome-wide detection of signatures of selection in indicine and Brazilian locally adapted taurine cattle breeds using whole-genome re-sequencing data
Creators: name: Peripolli, Elisa
name: Reimer, Christian
name: Ngoc-Thuy Ha
name: Geibel, Johannes
name: Machado, Marco Antonio
name: Panetto, João Cláudio Do Carmo
name: Egito, Andréa Alves Do
name: Baldi, Fernando
name: Simianer, Henner
name: Silva, Marcos Vinícius Gualberto Barbosa Da
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4. Analysis of Molecular Variance results.
Electrical engineering education in the brave new world: a program based philosophy to graduate development
Creators: name: Senini, Steven
name: Hosseinzadeh, Nasser
Publisher: name: Swinburne
Year: 2024

description: Central Queensland University (CQU) has long been recognised as a provider of engineering teaching excellence to the Central Queensland region and beyond. As the requirements of the stakeholders in the engineering education process has changed, CQU has adapted its offerings and incorporated new, brave and innovative approaches to maintaining its market share in this industry. CQU currently offers electrical engineering undergraduate programs at Associate Degree (ADE), Bachelor of Engineering Technology (BET) and Bachelor of Engineering (BE) Levels. This paper will outline the history of innovation at CQU, the previous program structure and the items which this review has tried to improve. The paper will also explore the process of review, the factors influencing decision making and the proposed new structure for all levels of undergraduate electrical engineering programs. In addition to the increased integration of the programs, the electrical engineering program has a greater power engineering focus and a stronger emphasis on Project/Problem Based delivery across the suite of programs. The new programs and associated assessment/delivery processes will shape the future of engineering education into the new millennium.
DEP Bulletin - 2022 - Volume 46 Issue 22
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2022

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Dancing with Difference: An Auto/ethnographic Analysis of Dominant Discourses in Integrated Dance
Creators: name: Irving, Hannah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Integrated Dance
Foucauldian Theory
Discourse Analysis
Autoethnography
Ethnography

description: Through six months of ethnographic and autoethnographic fieldwork, which included participant observation and ten individual semi-structured interviews, I sought to determine how dominant discourses in dance, especially those pertaining to professionalism, ability, validity, and legitimacy, are circulated in and through training, and how we as dancers responded to these discourses. Following the stand alone thesis format, this thesis is comprised of two publishable papers. The first is an ethnography of one integrated dance company’s members’ experience with negotiating space for alternative forms of dance in contemporary dance. The second is an autoethnographic piece of writing where I show the challenges of resisting dominant discourses of validity and legitimacy in both qualitative research as well as contemporary dance. Together, these papers form a thesis that strengthens our scholarly understanding of the discourses and associated tensions at work in participating in and writing about integrated dance.
Hypatia's Math
Creators: name: Del Bel, Julian
Publisher: name: Zenodo
Year: 2025

description: Physical phenomena emerge from the combined contributions of all ”places” – including thereal continuum and p-adic number fields. We present a concrete implementation of this principlethrough precise numerical integration, demonstrating how these divergent contributions can bereconciled to produce normalized physical quantities. Adelic integration emerged in reconcilingquantum field theoretic models with number-theoretic methods. In this work, we develop aquantum-consistent framework wherein contributions from the real continuum and the p-adicspectrum are integrated with Euler-like prime factors. A critical aspect of our model is theanomaly detection mechanism, which is essential for ensuring that recursive expansions do notpropagate numerical instabilities
Additional file 1 of Dual-energy CT in gout patients: Do all colour-coded lesions actually represent monosodium urate crystals?
Creators: name: Christiansen, Sara Nysom
name: Müller, Felix Christoph
name: Østergaard, Mikkel
name: Slot, Ole
name: Møller, Jakob M.
name: Børgesen, Henrik F.
name: Gosvig, Kasper Kjærulf
name: Terslev, Lene
Publisher: name: figshare
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1. Location map for registration of colour-coded DECT lesions.
Influencing employee innovation through structural empowerment initiatives: the need to 'feel' empowered
Creators: name: Knight-Turvey, Neal
Publisher: name: Swinburne
Year: 2024

description: This study examines the relationship between various structural empowerment initiatives, psychological empowerment, and employee innovation. Structural empowerment initiatives---defined here as progressive human resource management practices that include participative decision making, information sharing, recognition and reward, training and development, and non-excessive workload---were hypothesised to impact the innovation process indirectly through psychological empowerment. A questionnaire survey among 756 employees from an Australian manufacturing firm provides some support for the proposed indirect linkage. Overall, findings suggest it is not sufficient to simply provide empowering conditions in the workplace (e.g., structural empowerment initiatives like progressive HRM practices). Instead, employees must psychologically interpret and react to these conditions via felt empowerment. Theoretical and practical implications of these findings are discussed.
Sélectionner des gens de valeurs? Représentations et frontières nationales dans la Déclaration sur les valeurs communes de la société québécoise
Creators: name: Fortin-Lauzier, Catherine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Immigration
Québec
Intégration
Valeurs communes
Représentations

description: En 2008, le ministère de l’Immigration et des Communautés culturelles a créé un document destiné aux immigrants, la Déclaration sur les valeurs communes de la société québécoise. Dans cette thèse, je m’intéresse à ce document en étudiant les représentations des personnes immigrantes et des Québécois. D’abord, en replaçant le document dans le contexte de la « crise » des accommodements raisonnables, on constate qu’il agit en réaffirmant les frontières de la nation québécoise, par des représentations dichotomiques tradition/modernité. L’utilisation d’un discours visant à protéger les droits des femmes permet ainsi de distinguer les immigrants désirables des indésirables, et de présenter les Québécois en champions de ces valeurs. Des rencontres avec des personnes ayant récemment immigré au Québec montrent que ceux-ci s’adaptent bien à ces valeurs, contrairement aux représentations offertes durant la « crise ». Leurs défis se situent à un autre niveau : l’insertion au marché du travail québécois.
Effect of Crude Glycerol from Biodiesel Production on the Performance and Anaerobic Metabolism of Catalysts in a Glycerol Oxidizing Microbial Fuel Cell
Creators: name: Sivell, Jamie-Lynn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Microbial fuel cell
Glycerol
Biodiesel

description: Use of waste glycerol as fuel in microbial fuel cells (MFCs) would result in the production of valuable metabolites and electricity, to the benefit of biodiesel operations. In this research, the effect of salt and other compounds found in waste glycerol from biodiesel production on the metabolism and performance of three cultures (Escherichia coli W3110, Propionibacterium freudenreichii ssp. shermanii and mixed culture AR2), used as anodic catalysts in an MFC was studied. MFC experiments were performed in parallel with serum bottle fermentations to allow for comparison of glycerol consumption and metabolite yield. The effect of salt content on the performance of all three cultures was positive in most cases and negligible in others. Using waste glycerol with an increased concentration of other compounds (other than salt) only reduced the performance of AR2, however an inhibitory effect on the rate of glycerol consumption was observed with both AR2 and P. freudenreichii ssp. shermanii. For all strains, the rate of glycerol consumption was slower in MFCs than in fermentations as a result of the electrochemical environment; the yield of various metabolites also differed.
Additional file 1 of Prevalences and associated factors of electrocardiographic abnormalities in Chinese adults: a cross-sectional study
Creators: name: Liping Yu
name: Xiaojun Ye
name: Zhaojun Yang
name: Wenying Yang
name: Zhang, Bo
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. The odds ratios of the effects of prediabetes and overweight on ECG abnormalities. Table S2. Comparison of the characteristics of the included and excluded populations
The Social Construction of Intensive Care Nursing, 1960-2002: Canadian Historical Perspectives
Creators: name: Vanderspank, Brandi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Critical Care
subject: History of Critical Care
subject: History of Intensive Care Units
subject: History of Nursing
subject: Social History

description: Intensive care units (ICUs) emerged across Canada during the early 1960s, significantly contributing to the image of Western hospitals as places of scientific advancement that predominated over much of the twentieth century. ICUs rapidly became both a resource intensive and expensive type of care as the number and size of units increased to accommodate diverse patient populations and treatment options. Nurses enabled the formation and growth of ICUs through their constant presence and skilled care. There has been limited research, however, regarding the historical development of Canadian ICUs, the relationships between nurses and other personnel in such units, how they developed an identity as ICU nurses, or how ICU nursing became a specialty practice. Situated within the broader histories of hospitals, healthcare, and nursing, this study uses a social history approach to examine nurses’ experiences within Canadian ICUs between 1960 and 2002. Berger and Luckmann’s Social Construction of Reality provided a lens for analysis and interpretation of oral histories, photographs, professional literature of the time period under study, and both archival and organizational records. This thesis argues that ICU nurses’ relationships with one another, in the context of a technologically complex environment, socially constructed their knowledge and skill acquisition, their socialization as ICU nurses, and the development of a specialized body of knowledge that ultimately led to formal recognition of ICU nursing as a specialty in Canada.
The perspectives of youth workers in rural Victoria
Creators: name: Geldens, Paula
name: Bourke, Lisa
Publisher: name: Swinburne
Year: 2024

description: Youth work is a diverse and challenging career that is continually debated and redefined. Most discussions of youth work, however, have not accounted for differences in geographic location. This paper explores the perspectives of 107 youth workers across rural Victoria in relation to their job satisfaction and support, types of practice, goals and philosophies and the challenges of being a rural practitioner.
Network Decontamination Using Cellular Automata
Creators: name: Rakotomalala, Livaniaina Hary
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Network Decontamination
Cellular Automata

description: We consider the problem of decontaminating a network where all nodes are infected by a virus. The decontamination strategy is performed using a Cellular Automata (CA) model in which each node of the network is represented by the automata cell and thus, the network host status is also mapped to the CA state (contaminated, decontaminating, decontaminated). All hosts are assumed to be initially contaminated and the status of each cell is synchronously updated according to a set of local rules, based on the state of its neighbourhood. Our goal is to find the set of local rules that will accomplish the decontamination in an optimal way. The metrics used to define optimality is the minimization of three metrics: the maximum number of decontaminating cells at each step, the required value of the immunity time of each cell and the number of steps to complete the sanitization algorithm. In our research, we explore the designing of these local decontamination rules by refining the concept of the neighbourhood radius of CA with the addition of two new dimensions: Visibility Hop and Contamination Distance. Additionally, a research tool that help us manage our study have been developed.
Additional file 1 of Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation
Creators: name: Siddiqui, Sahabjada
name: Mahdi, Abbas Ali
name: Md Arshad
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Additional file 1.
Additional file 1 of Massive hemothorax due to bleeding from thoracic spinal fractures: a case series and systematic review
Creators: name: Ninomiya, Kohei
name: Kuriyama, Akira
name: Hayaki Uchino
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Cancer
subject: Hematology

description: Additional file 1.
Additional file 1 of Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis
Creators: name: Stoccoro, Andrea
name: Smith, Adam R.
name: Mosca, Lorena
name: Marocchi, Alessandro
name: Gerardi, Francesca
name: Lunetta, Christian
name: Cereda, Cristina
name: Gagliardi, Stella
name: Lunnon, Katie
name: Migliore, Lucia
name: Coppedè, Fabio
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Table S1. Details of SOD1 pathogenic variants (NM_000454) in ALS patients.
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine
Creators: name: Weber, Patrick
name: Thonhofer, Martin
name: Averill, Summer
name: Davies, Gideon J.
name: Santana, Andres Gonzalez
name: Müller, Philipp
name: Nasseri, Seyed A.
name: Offen, Wendy A.
name: Pabst, Bettina M.
name: Paschke, Eduard
name: Schalli, Michael
name: Torvisco, Ana
name: Tschernutter, Marion
name: Tysoe, Christina
name: Windischhofer, Werner
name: Withers, Stephen G.
name: Wolfsgruber, Andreas
name: Wrodnigg, Tanja M.
name: Stütz, Arnold E.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those of lipophilic analogs of the potent β-d-galactosidase inhibitor 4-epi-isofagomine. Structure-activity relationships were investigated by X-ray crystallography as well as by alterations in the cyclopentane moiety such as deoxygenation and replacement by fluorine of a “strategic” hydroxyl group. New compounds have revealed highly promising activities with a range of β-galactosidase-compromised human cell lines and may serve as leads towards new pharmacological chaperones for GM1-gangliosidosis and Morquio B disease.
L’influence du facteur juridique sur les évolutions politiques de l’Égypte à l’ère Hosni Moubarak
Creators: name: Shalaby, Omar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: constitutionalisme
Egypte justice
droits politiques Egypte
Constitutionalisme Egypte/Moyen-Orient
Profession judiciaire Egypte
Autoritarisme Egypte/Moyen-Orient
libertés fondamentales Egypte
Constitutionalism
Judiciary Egypt
Authoritarian regime Egypt/Middle East
political rights Egypt
consitutional review Egypt
contrôle de la constitutionalité Egypte
Juridical professions Egypt

description: Le monde arabe, où l’Égypte occupe une place de choix par sa situation géographique et son histoire, n’a pas connu de gouvernements démocratiques depuis l’accès à l’indépendance des pays le composant. On soulève dans ce travail la question des mécanismes de la survivance autoritaire dans le monde arabe en prenant pour cas d’étude le régime d’Hosni Moubarak, les récentes mobilisations de janvier 2011 constituant à notre avis un « test » pour les dynamiques d’ajustement autoritaire à l’œuvre depuis trente ans en Égypte. Alors que certains auteurs soutiennent la cause d’une judiciarisation de la vie politique en Egypte stimulée par la place du droit et des juridictions judiciaires dans le pays, dans quel sens ont évolué les marges de manœuvre d’agents politiques et juridiques égyptiens ? La Haute Cour constitutionnelle a-t-elle été un facteur de stabilisation pour le régime autoritaire d’Hosni Moubarak ou bien, a-t-elle constitue un rempart contre le régime en place? Alors que les Democratization studies ont démontré leurs limites conceptuelles pour appréhender les évolutions politiques dans un espace supposément aux prises avec une « exception autoritaire » régionale, cette recherche s’inscrit dans la vague d’écrits offrant une lecture de la reconfiguration autoritaire dans l’espace arabe. En premier lieu, nous analyserons l’impact de l’activité jurisprudentielle émanant de la Haute Cour constitutionnelle égyptienne en matière de défense des droits politiques, et cela afin de montrer de quelle manière cette institution a participé à la survivance du régime de Moubarak (1981-2010). En second lieu, on confirmera nos observations à partir d’une étude portant sur les droits économiques levant le voile sur une « complaisance stratégique » des juges constitutionnels vis-à-vis du pouvoir politique. Néanmoins, ce ne sera qu’en remettant en contexte cette sphère professionnelle qu’il sera possible, dans un troisième temps, d’en expliquer les raisons en appréciant la sensibilité de ce segment professionnel à la notion d’indépendance judiciaire.
Functional Genetic Analysis Reveals Intricate Roles of Conserved X-box Elements in Yeast Transcriptional Regulation
Creators: name: Voll, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: functional genetic analysis
transcription factor (TF)
cis-regulatory element (CRE)
binary interaction
higher order interaction
multiple linear regression
additive
multiplicative
synthetic genetic array (SGA)
green fluorescent protein (GFP)
ribonucleotide reductase (RNR)
yeast
X-box
transcriptional regulation
RNR3

description: Understanding the functional impact of physical interactions between proteins and DNA on gene expression is important for developing approaches to correct disease-associated gene dysregulation. I conducted a systematic, functional genetic analysis of protein-DNA interactions in the promoter region of the yeast ribonucleotide reductase subunit gene RNR3. I measured the transcriptional impact of systematically perturbing the major transcriptional regulator, Crt1, and three X-box sites on the DNA known to physically bind Crt1. This analysis revealed interactions between two of the three X-boxes in the presence of Crt1, and unexpectedly, a significant functional role of the X-boxes in the absence of Crt1. Further analysis revealed Crt1- independent regulators of RNR3 that were impacted by X-box perturbation. Taken together, these results support the notion that higher-order X-box-mediated interactions are important for RNR3 transcription, and that the X-boxes have unexpected roles in the regulation of RNR3 transcription that extend beyond their interaction with Crt1.
title: Nachzulassungsmonitoring im Zulassungsverfahren von Pflanzenschutzmitteln : Messstellen-Vorauswahl durch die Bundesländer
title: Nachzulassungsmonitoring im Zulassungsverfahren von Pflanzenschutzmitteln : Messstellen-Vorauswahl durch die Bundesländer
titleType: AlternativeTitle
Creators: name: Bach, Thomas
name: Hilliges, Falk
name: Börke, Peter
name: König, Wolfram
name: Marahrens, Stephan
name: Müller, Alexandra
name: Pickl, Christina
name: Rauch, Mark
Publisher: name: Umweltbundesamt
Year: 2020

description: Nachzulassungsmonitoring im Grundwasser ist ein Instrument im Rahmen der nationalen Zulassung von Pflanzenschutzmitteln. Der Verfahrensablauf für diesen Studientyp wird neu geregelt, insbesondere die freiwillige Auswahl von Messtellen durch die Länderbehörden aus ihren Messnetzen. Im Kriterienkatalog sind Kriterien für geeignete Messstellen festgelegt und priorisiert. Quelle: https://www.umweltbundesamt.de
Theoretical and Experimental Studies of Electronic Structure, Magnetic, and Hyperfine Interaction Properties of Novel Compounds
Creators: name: Nejadsattari, Farshad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016

description: This thesis consists of the results of theoretical and experimental studies on the electronic structure, magnetic properties and hyperfine-interaction parameters of five compounds. The theoretical studies are based on ab-initio calculations, and the experimental studies are based on Mössbauer spectroscopy, magnetic measurements, and X-ray powder diffraction measurements. The calculated hyperfine-interaction parameters are shown to be in good agreement with the corresponding experimental parameters for all studied compounds. Al13Fe4 crystallizes in the monoclinic space group 𝐶2/𝑚, in which Fe atoms are located at five inequivalent crystallographic sites. It is shown that the zero-field Mössbauer spectra can be decomposed into three quadrupole doublets. It is found that the shape of the Mössbauer spectrum measured in an external magnetic field can be accounted for with five component subspectra generated using the calculated EFG parameters at five inequivalent Fe sites. A pseudogap is observed in the density of states (DOS) in the vicinity of the Fermi level. The recently discovered layered iron oxyselenide Na2Fe2Se2O is confirmed to be a Mott insulator. It is demonstrated that Na2Fe2Se2O orders antiferromagnetically. The Debye temperature of Na2Fe2Se2O is found to be 274(3) K. The Fe2NiGa compound crystallizes in the cubic space group 𝐹4 ̅3𝑚 and is predicted to be half-metallic with covalent chemical bonding. It orders ferromagnetically. The saturation magnetization per formula unit and the estimated Fe magnetic moments at the A and B sites are given. It is observed that the magnetic properties of Fe2NiGa are very strongly dependent on their heat treatment. The presence of a mixture of strong covalent and weak ionic chemical bonding and of metallic characteristics for the (Li0.8Fe0.2)OHFeSe superconductor is shown. The Mössbauer spectra consist of two quadrupole-doublet patterns. It is demonstrated that there is no magnetic ordering of the 2𝑎-site Fe magnetic moments down to 2.0 K. The final compound is the Al76Ni9Fe15 approximant. The existence of a pseudogap in the calculated electronic density of states slightly above the Fermi level suggests electronic stabilization according to the Hume-Rothery-type mechanism. High metallicity is predicted. Both the Mössbauer spectra and magnetic susceptibility data indicate that Al76Ni9Fe15 is a paramagnet down to 2.0 K.