cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cholecalciferol (vitamin D3) has a direct protective activity in C2C12 myotubes
Creators: name: ALVES TEIXEIRA, MARAIZA
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2021

description: Skeletal muscle depletion occurs, among other conditions, in oncologic patients. Cancer cachexia is a multicomponent syndrome which physiopathology involves metabolic alterations, like hormonal imbalance. One of the hormones that are dysregulated in cancer cachexia is Vitamin D (VD). Besides its important role in bone mineralization, regulating calcium and phosphate homeostasis, VD affects skeletal muscle. In fact, VD deficiency has been associated with a wide range of muscle disorders, such as a decrease in muscle mass and functionality. Even though VD deficiency is highly prevalent among advanced cancer patients with cachexia, the administration of VD in these subjects showed inconclusive results, with VD supplementation being ineffective to prevent muscle wasting in both cachectic patients and tumor-bearing animals.
We show how different VD metabolites trigger contrasting effects on skeletal muscle in vitro, depending on the sites of hydroxylation or doses, thus explaining the limitations of VD-based therapy in vivo, once VD systems of biosynthesis and catabolism are dysregulated in cancer.
We find that also cholecalciferol (VD3), the non-hydroxylated upstream VD metabolite, has a direct effect on muscle cells. This finding might help to make future progress in developing VD analogs with a restricted capacity to undergo hydroxylation. Then overcoming the limitations of VD supplementation in cancer-related cachexia.
PHOSPHATIDYLSERINE TARGETING FOR ENHANCING CHEMOIMMUNOTHERAPY OF CANCER
Creators: name: Wang, Jianping
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 321405
subject: Pharmaceutical sciences
classificationCode: 321404
subject: Pharmaceutical delivery technologies

description: Immunotherapy has significantly improved cancer treatment. However, many tumors are resistant to current immunotherapy due to the highly immunosuppressive tumor microenvironment (TME). Tumor cells can evade immune activation by externalizing phosphatidylserine (PS) on cell surface to trigger anti-inflammatory signals and induce immune tolerance. Recent studies show that PS is upregulated in TME and further increased after chemotherapy. For effective immunotherapy of tumors, the exposed PS needs to be blocked to relieve immunosuppressive TME and sensitize tumors to immune stimulants. 

In this study, PS exposure level increased after the chemotherapy Doxil treatment on B16F10 melanoma cells, and the PS exposure reduced the response of antigen-presenting cells (APCs) to immune stimulants such as lipopolysaccharide. Dipicolylamine-Zn (DPA-Zn) shielded the PS exposure resulting from doxorubicin (DOX) treatment and reduced immunosuppressive interaction between tumors and APCs. The PS blockade by DPA-Zn improves the tumor response rate immune stimulants such as GM-CSF, STING agonist cyclic dinucleotides (CDN), anti-PD-L1 antibody. Among the combination at the tested doses, Doxil + DPA-Zn + CDN was the optimal combination that enhanced anti-tumor effect most significantly and prolonged the survival time in immune-cold B16F10 melanoma model. However, the anti-tumor efficacy was limited, which is attributed to poor tumor retention of CDN and DPA-Zn. 

To prolong the intratumoral release of DPA-Zn and CDN and maximize the anti-tumor immunity, CDN was formulated as liposomes (CDN@lip), which significantly delayed the release of CDN in vitro and improved anti-tumor efficacy compared with free CDN formulation. Alginate hydrogel showed the potential to sustain release of DPA-Zn. DPA-Zn was loaded in the alginate hydrogel via electrostatic interaction, and the release rate was controlled by additional zinc gluconate. However, zinc caused detrimental effects on skin and can cause mice death at a high dose. To avoid the side effect of subcutaneously administered Zn, the dose of DPA-Zn in alginate hydrogel was readjusted based on the maximum tolerated dose study, and zinc gluconate was replaced with CaSO4.
25 | 2016
Creators: name: Mantoan, Diego
name: Dreon, Roberta
name: AA.VV
Publisher: name: Università Ca’ Foscari Venezia, Italia
Year: 2016

description:

description: Venezia Arti
I luoghi dell'insediamento: migrazioni post-sovietiche e cambiamento culturale nello spazio urbano
Creators: name: Cvajner, Martina
Publisher: name: Universit� degli Studi di Trento
Year: 2017

description: In questo contributo, le migrazioni post-sovietiche vengono affrontare da una prospettiva �classica� risalente alla scuola di Chicago - ancora poco utilizzata nel caso delle migrazioni femminili. Attingendo ai risultati di un progetto etnografico che per un decennio mi ha coinvolta nell?osservazione del processo di radicamento di un gruppo di donne post-sovietiche arrivate in una citt� del nord-est italiano, mostrer� come tali donne siano lentamente divenute parte integrante del panorama cittadino. La dimensione di spazialit� urbana descritta solleva molti interrogativi importanti non soltanto per chi si occupa di migrazioni femminili, ma per chiunque fosse interessato al cambiamento relazionale e culturale. Trattasi di donne inserite nel mercato del lavoro domestico, migrate da sole e spesso prive di reti familiari funzionanti nel contesto d?arrivo. Come sono riuscite nella creazione di un minimo di sciabilit� indipendente dalla loro occupazione? Quali sono i canali che gli hanno consentito di inserirsi nella vita cittadina �conquistando� degli spazi riconosciuti? Come � cambiato nel tempo l?uso dello spazio urbano, con la crescita dell?anzianit� migratoria delle donne gi� insediate? Cosa � successo negli oltre tre lustri trascorsi dal loro arrivo?
Supplemental Material, sj-pdf-1-smq-10.1177_15245004211030965 - Consumer Journeys of Adolescent Girls and Young Women in South Africa: Implications for Marketing HIV Prevention Products
Creators: name: Dugas, Michelle
name: Crowley, Kenyon
name: Gao, Guodong (Gordon)
name: McHarry, Lorcan
name: Kenmuir, Louise
name: Piper, Jeanna
name: Veronese, Fulvia
name: Agarwal, Ritu
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, sj-pdf-1-smq-10.1177_15245004211030965 for Consumer Journeys of Adolescent Girls and Young Women in South Africa: Implications for Marketing HIV Prevention Products by Michelle Dugas, Kenyon Crowley, Guodong (Gordon) Gao, Lorcan McHarry, Louise Kenmuir, Jeanna Piper, Fulvia Veronese and Ritu Agarwal in Social Marketing Quarterly
Nonparametric Mixture Modeling on Constrained Spaces
Creators: name: Sudyanti, Putu Ayu G
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Statistics not elsewhere classified

description: Mixture modeling is a classical unsupervised learning method with applications to clustering and density estimation. This dissertation studies two challenges in modeling data with mixture models. The first part addresses problems that arise when modeling observations lying on constrained spaces, such as the boundaries of a city or a landmass. It is often desirable to model such data through the use of mixture models, especially nonparametric mixture models. Specifying the component distributions and evaluating normalization constants raise modeling and computational challenges. In particular, the likelihood forms an intractable quantity, and Bayesian inference over the parameters of these models results in posterior distributions that are doubly-intractable. We address this problem via a model based on rejection sampling and an algorithm based on data augmentation. Our approach is to specify such models as restrictions of standard, unconstrained distributions to the constraint set, with measurements from the model simulated by a rejection sampling algorithm. Posterior inference proceeds by Markov chain Monte Carlo, first imputing the rejected samples given mixture parameters and then resampling parameters given all samples. We study two modeling approaches: mixtures of truncated Gaussians and truncated mixtures of Gaussians, along with Markov chain Monte Carlo sampling algorithms for both. We also discuss variations of the models, as well as approximations to improve mixing, reduce computational cost, and lower variance.
The second part of this dissertation explores the application of mixture models to estimate contamination rates in matched tumor and normal samples. Bulk sequencing of tumor samples are prone to contaminations from normal cells, which lead to difficulties and inaccuracies in determining the mutational landscape of the cancer genome. In such instances, a matched normal sample from the same patient can be used to act as a control for germline mutations. Probabilistic models are popularly used in this context due to their flexibility. We propose a hierarchical Bayesian model to denoise the contamination in such data and detect somatic mutations in tumor cell populations. We explore the use of a Dirichlet prior on the contamination level and extend this to a framework of Dirichlet processes. We discuss MCMC schemes to sample from the joint posterior distribution and evaluate its performance on both synthetic experiments and publicly available data.
'Bonus iudex'. Saggi sulla tutela della giustizia tra Medioevo e prima et� moderna
Creators: name: Natalini, Cecilia Frida
Publisher: name: Universit� degli Studi di Trento
Year: 2016

description: La tradizione giuridica occidentale lega il problema della giustizia all?enunciazione ulpianea secondo cui la tutela del diritto e dei diritti dei singoli dipende dalla volont� del soggetto giudicante, ovvero il giurista ?sacerdote del diritto?. La limpidezza dei principii teorici preposti al reddere iura pu� dunque trovare opposizione nei comportamenti fattuali che inquinano, indeboliscono, frenano il dispiegarsi della volont�. Le fonti teologico-giuridiche occidentali presentano, fin dal Tardo Antico e fino alle soglie dell?et� moderna, un solido impianto volto a disciplinare la voluntas del bonus iudex non entro i confini di un sistema legalistico, ma entro i limiti ordinativi dell?interpretatio. Quest?ultima � studiata non soltanto dal punto di vista della voluntas activa, per indicare ci� da cui il iudex deve astenersi al fine di garantire la corretta formazione del giudizio, ma anche con riferimento all?eventuale comportamento omissivo, capace di alterare altrettanto gravemente l?officium iudicis.
Lagged diffusivity method for the solution of nonlinear diffusion convection problems with finite differences
Creators: name: GALLIGANI, Emanuele
Publisher: name: Dipartimento di Ingegneria Enzo Ferrari - Universit� di Modena e Reggio Emilia
Year: 2011

description: This paper concerns with the analysis of an iterative procedure for the solution of a nonlinear nonstationary diffusion convection equation in a two dimensional bounded domain supplemented by Dirichlet boundary conditions. This procedure, denoted Lagged Diffusivity method, computes the solution by lagging the diffusion term. A model problem is considered and a finite difference discretization for that model is described. Furthermore, properties of the finite difference operator are proved. Then, a sufficient condition for the convergence of the Lagged Diffusivity method is given. At each stage of the iterative procedure a linear system has to be solved and the Arithmetic Mean method is used. Numerical experiments show the efficiency, for different test functions, of the Lagged Diffusivity methodcombined with the Arithmetic Mean method as inner solver. Better results are obtained when the convection term increases.
Supplemental Material, sj-pdf-1-tva-10.1177_15248380211029407 - Newspaper Coverage of Adverse Childhood Experiences and Toxic Stress in the United States, 2014–2020: Consequences, Causes, and Solutions
Creators: name: Purtle, Jonathan
name: Bowler, Sarah
name: Boughter-Dornfeld, Maura
name: Nelson, Katherine L.
name: Gollust, Sarah E.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-1-tva-10.1177_15248380211029407 for Newspaper Coverage of Adverse Childhood Experiences and Toxic Stress in the United States, 2014–2020: Consequences, Causes, and Solutions by Jonathan Purtle, Sarah Bowler, Maura Boughter-Dornfeld, Katherine L. Nelson and Sarah E. Gollust in Trauma, Violence, & Abuse
Il declino della distinzione tra diritto pubblico e diritto privato. Atti del IV Congresso nazionale SIRD. Trento, 24-26 settembre 2015
Creators: name: Benacchio, Gian Antonio
name: Graziadei, Michele
Publisher: name: Universit� degli Studi di Trento
Year: 2016

description: Il volume accoglie gli atti del IV Congresso nazionale della Societ� Italiana per la Ricerca nel Diritto Comparato. La distinzione tra diritto pubblico e diritto privato � rivisitata in prospettiva storica, comparata ed europea da Stefano Battini, Giuseppe Bellantuono, Gian Antonio Benacchio, Giacomo Delledonne, Andrea Giardina, Jean-Louis Halp�rin, Giulio Napolitano, Renato Nazzini, Barbara Pozzo, Ruth Rubio-Mar�n, Rodolfo Sacco, Mario Serio, Pietro Sirena, Bernardo Sordi. I contributi su temi specifici spaziano dalla responsabilit� civile alla famiglia, dall?antitrust agli investimenti e all?arbitrato, alla regolazione dell?ambiente e dei mercati.
sj-pdf-4-cjk-10.1177_20543581211033496 – Supplemental material for Expanding the Deceased Donor Pool in Manitoba Using Hepatitis C-Viremic Donors: Program Report
Creators: name: Cuvelier, Susan
name: Van Caeseele, Paul
name: Kadatz, Matthew
name: Peterson, Kathryn
name: Sun, Siyao
name: Dodd, Nancy
name: Werestiuk, Kim
name: Koulack, Joshua
name: Nickerson, Peter
name: Ho, Julie
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-4-cjk-10.1177_20543581211033496 for Expanding the Deceased Donor Pool in Manitoba Using Hepatitis C-Viremic Donors: Program Report by Susan Cuvelier, Paul Van Caeseele, Matthew Kadatz, Kathryn Peterson, Siyao Sun, Nancy Dodd, Kim Werestiuk, Joshua Koulack, Peter Nickerson and Julie Ho in Canadian Journal of Kidney Health and Disease
Additional file 1 of Diversified caregiver input to upgrade the Young Children’s Participation and Environment Measure for equitable pediatric re/habilitation practice
Creators: name: Villegas, Vivian C.
name: Bosak, Dianna L.
name: Salgado, Zurisadai
name: Phoenix, Michelle
name: Parde, Natalie
name: Teplicky, Rachel
name: Khetani, Mary A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Additional file 1. Appendix.
MyHealthMyData (MHMD): Deliverable 3.2 - Ethical Review materials and engagement process definition
Creators: name: De Maldè, Mirko
name: Durst, Ludovica
name: Catterall, Noel
Publisher: name: Zenodo
Year: 2018

description: The present deliverable is aimed at providing a general evaluation framework for the management of patient consent in MHMD, and its implementation as a smart contract. Such framework will serve as the basis for submitting in due course the needed requests, to MHMD partner hospitals’ Ethics Committees, in view of being authorised to deploy dynamic consent applications within their patient populations. If successful, the outcome of this activity will represent a major result of the project, as it will deliver one of the first ethically compliant (and approved) blockchain architectures specifically conceived for health data management and exchange. The scope of this deliverable has been updated to take into account the changes in task T3.2, as indicated in the recently submitted Amendment, in particular to reflect the new strategy for implementing dynamic consent through smart contracts and leverage the blockchain to make consent management process (from the provision of consent to the ex-post verification of existence of such consent) transparent, semi-automatic and tamper proof.1 The change in strategy was deemed necessary to provide the Ethics Committees not only with the supporting documentation needed for approving a novel mechanism for expressing and managing consent (becoming fully dynamic through smart contracts), but also to encode the conceptual consent framework on which to obtain a comprehensive and robust ethical approval – incorporating the ways in which consent is implemented on the blockchain in code, shared with external parties, and automatically self-enacted and possibly modified by the patient. With this document, an iterative process will be activated, using feedback gathered from Ethics Committees in order to better specify the entire process and corresponding IT architecture. The subsequent phases of the iteration are provided in section 4.4.5 (MHMD approach). Beside presenting the issue of how to translate dynamic consent into smart contracts, this document will also provide a preliminary recognition and analysis of the technological approaches currently followed for smart contracts implementation, thus presenting a general development framework for applying the dynamic consent concept though smart contracts within MHMD.
Characterization of The Flow Quality in the Boeing Subsonic Wind Tunnel
Creators: name: Diffey, Claire S
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace engineering not elsewhere classified
Aerodynamics (excl. hypersonic aerodynamics)
Flight dynamics

description: Good wind-tunnel flow quality characteristics are vital to using test data in the aerodynamic design process. Spatially uniform velocity profiles are required to avoid yaw and roll moments that would not be present in real flight conditions. Low turbulence intensity levels are also important as several aerodynamic properties are functions of turbulence intensity. When measuring mean flow and turbulence properties, hot-wire anemometry offers good spatial resolution and high-frequency response with a fairly simple operation, and the ability to make near-wall measurements. Using hot-wire anemometry, flow quality experiments were conductedin a closed-circuit wind tunnel with a test section that has a cross section area of 1.2 m x 1.8 m (4 ft. x 6 ft.). The experiments included measurements of flow velocity and turbulence intensity variation over the test section cross-section, spatial and temporal temperature variation, andboundary layer measurements. The centerline velocity and turbulence intensity were also measured for flow speeds ranging from 13 to 43 m/s.
Towards a History of the Italian Industrial Districts from the End of World War II to the Nineties,
Creators: name: BRUSCO, Sebastiano
name: PABA, Sergio
Publisher: name: Dipartimento di Economia Politica - Universit� di Modena e Reggio Emilia
Year: 2014

description: When did the first Italian industrial districts spring up? In which regions have they developed, and over what times, in the forty years of republican Italy from the end of World War II to the nineties? How do districts develop? How do they change their shape in time? By using for the first time comparable census data from 1951 to 1991 and with reference to the main existing literature on the subject, we try to answer these questions and to trace a history of the Italian industrial districts. In the discussion, we enquire into how the importance and role of the districts vary over time, and we attempt to assess their prevailing working conditions, their efficiency and their ability to face up to international competition.
Jwst Python Data-Analysis Tools
Creators: name: Lim, Pey Lian
name: Ferguson, Henry C.
Publisher: name: Zenodo
Year: 2018
Subjects: pyastro18
Python
astronomy
data analysis

description: A short talk about Python Data-Analysis Tools developed at STScI. They are developed with JWST in mind but mostly telescope-agnostic and would apply to other telescopes as well. At the end of the talk, there was also a short live demo of CubeViz, a visualization tool for data cubes (http://cubeviz.readthedocs.io/en/latest/), which is not included here.
Are defined contribution pension schemes socially sustainable? A conceptual map from a macroprudential perspective
Creators: name: MAROTTA, Giuseppe
Publisher: name: Dipartimento di Economia Marco Biagi - Universit� di Modena e Reggio Emilia
Year: 2011

description: If the combined retirement income, provided by public and private defined contribution (DC) pension schemes, falls below socially acceptable standards, there is a political risk that consensus seeker policymakers could yield to pressures to commit future fiscal revenues. These contingent liabilities, when incorporated in markets? expectations, are bound to create spillovers on sovereign risk, with negative feedback loops on the capital adequacy of banks and of other intermediaries, owing to losses on their government paper. Among the causes of reduced annuities out of the final assets in DC pension funds is an equity risk premium much lower than the commonly values advertised by the industry and by policymakers. From a macroprudential perspective, this political risk should be taken into account in stress tests assessing banks? resilience to financial shocks.
Additional file 1 of Characteristics of infections with ancestral, Beta and Delta variants of SARS-CoV-2 in the PHIRST-C community cohort study, South Africa, 2020-2021
Creators: name: Cohen, Cheryl
name: Kleynhans, Jackie
name: von Gottberg, Anne
name: McMorrow, Meredith L.
name: Wolter, Nicole
name: Bhiman, Jinal N.
name: Moyes, Jocelyn
name: du Plessis, Mignon
name: Carrim, Maimuna
name: Buys, Amelia
name: Martinson, Neil A.
name: Kahn, Kathleen
name: Tollman, Stephen
name: Lebina, Limakatso
name: Wafawanaka, Floidy
name: du Toit, Jacques
name: Gómez-Olivé, Francesc Xavier
name: Dawood, Fatimah S.
name: Mkhencele, Thulisa
name: Tempia, Stefano
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 1.
sj-pdf-1-tab-10.1177_1759720X211028001 – Supplemental material for Intervertebral disc therapies for non-specific chronic low back pain: a systematic review and meta-analysis
Creators: name: Daste, Camille
name: Laclau, Stéphanie
name: Boisson, Margaux
name: Segretin, François
name: Feydy, Antoine
name: Lefèvre-Colau, Marie-Martine
name: Rannou, François
name: Nguyen, Christelle
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-1-tab-10.1177_1759720X211028001 for Intervertebral disc therapies for non-specific chronic low back pain: a systematic review and meta-analysis by Camille Daste, Stéphanie Laclau, Margaux Boisson, François Segretin, Antoine Feydy, Marie-Martine Lefèvre-Colau, François Rannou and Christelle Nguyen in Therapeutic Advances in Musculoskeletal Disease
Iptacopan in paroxysmal nocturnal haemoglobinuria: a profile of its use
Creators: name: Shirley, Matt
name: Brown, Michael
Publisher: name: Adis Journals
Year: 2025
Subjects: Medicine
Haematology

description: Funding The preparation of this review was not supported by any external funding.

Authorship and conflict of interest M. B. Brown and M. Shirley are salaried employees of Adis International Ltd/Springer Nature and declare no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.

Ethics approval, Consent to participate, Consent for publication, Availability of data and material, Code availability Not applicable.

Additional information about this Adis Drug Review can be found here.

Abstract
Iptacopan (Fabhalta®), a complement factor B inhibitor, is a valuable treatment option for adult patients with paroxysmal nocturnal haemoglobinuria (PNH). It is the first oral monotherapy available for treatment of PNH in the USA and the EU. As demonstrated in the phase III clinical trials APPLY-PNH and APPOINT-PNH, twice daily iptacopan provided clinically meaningful improvements in haemoglobin levels in both anti-complement component 5 (anti-C5) therapy-experienced and complement inhibitor-naïve patients with PNH and anaemia. In APPLY-PNH, iptacopan was superior to continuing anti-C5 therapy at improving haemoglobin levels without the need for red blood cell transfusions (RBCTs). In both trials, iptacopan also reduced the need for RBCTs and reduced patient-reported fatigue levels. Iptacopan was generally well tolerated, with the most common adverse events being acute mild-to-moderate headache and with no discontinuations due to adverse events recorded in either trial. Currently available data show iptacopan efficacy is durable over 48 weeks; longer term efficacy and safety data are awaited with interest.

 © Springer Nature Switzerland AG 2025
sj-pdf-2-tar-10.1177_17534666211028072 – Supplemental material for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Creators: name: Liu, Panpan
name: Zhang, Huali
name: Zeng, Haizhu
name: Meng, Yingxia
name: Gao, Hongchang
name: Zhang, Meilan
name: Zhao, Lei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-2-tar-10.1177_17534666211028072 for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis by Panpan Liu, Huali Zhang, Haizhu Zeng, Yingxia Meng, Hongchang Gao, Meilan Zhang and Lei Zhao in Therapeutic Advances in Respiratory Disease
Systematic Evaluations Of Security Mechanism Deployments
Creators: name: Chau, Sze Yiu
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: System and network security
Software engineering not elsewhere classified

description: In a potentially hostile networked environment, a large diversity of security mechanisms with varying degree of sophistication are being deployed to protect valuable computer systems and digital assets.
While many competing implementations of similar security mechanisms are available in the current software development landscape, the robustness and reliability of such implementations are often overlooked, resulting in exploitable flaws in system deployments. In this dissertation, we systematically evaluate implementations of security mechanisms that are deployed in the wild. First, we examine how content distribution applications on the Android platform control access to their multimedia contents. With respect to a well-defined hierarchy of adversarial capabilities and attack surfaces, we find that many content distribution applications, including that of some world-renowned publications and streaming services, are vulnerable to content extraction due to the use of unjustified assumptions in their security mechanism designs and implementations. Second, we investigate the validation logic of X.509 certificate chains as implemented in various open-source TLS libraries. X.509 certificates are widely used in TLS as a means to achieve authentication. A validation logic that is overly restrictive could lead to the loss of legitimate services, while an overly permissive implementation could open door to impersonation attacks. Instead of manual analysis and unguided fuzzing, we propose a principled approach that leverages symbolic execution to achieve better coverage and uncover logical flaws that are buried deep in the code. We find that many TLS libraries deviate from the specification. Finally, we study the verification of RSA signatures, as specified in the PKCS#1 v1.5 standard, which is widely used in many security-critical network protocols. We propose an approach to automatically generate meaningful concolic test cases for this particular problem, and design and implement a provenance tracking mechanism to assist root-cause analysis in general. Our investigation revealed that several crypto and IPSec implementations are susceptible to new variants of the Bleichenbacher low-exponent signature forgery.
Additional file 1 of Moral disengagement and empathy in cyberbullying: how they are related in reflection activities about a serious game
Creators: name: Mateus Francisco, Sofia
name: Costa Ferreira, Paula
name: Veiga Simão, Ana Margarida
name: Salgado Pereira, Nádia
Publisher: name: figshare
Year: 2024
Subjects: Biological Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1
sj-pdf-2-jhs-10.1177_17531934211030438 - Supplemental material for A comparison of hand function in Colles and scaphoid casts using a modified Jebsen Hand Function Test
Creators: name: Vusirikala, Anuhya
name: Williams, Daniel
name: Koo, Hui Fen
name: Godwin, Joseph
name: Costalago, Leticia
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-2-jhs-10.1177_17531934211030438 for A comparison of hand function in Colles and scaphoid casts using a modified Jebsen Hand Function Test by Anuhya Vusirikala, Daniel Williams, Hui Fen Koo, Joseph Godwin, Leticia Costalago and Anthea Davy in Journal of Hand Surgery (European Volume)
sj-pdf-1-eex-10.1177_25151274211033155 - Supplemental material for Examination of Pedagogy and Instructional Innovation to Create Entrepreneurs in the Media and Technology Fields
Creators: name: Graybeal, Geoffrey M.
name: Ferrier, Michelle B.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-eex-10.1177_25151274211033155 for Examination of Pedagogy and Instructional Innovation to Create Entrepreneurs in the Media and Technology Fields by Geoffrey M. Graybeal and Michelle B. Ferrier in Entrepreneurship Education and Pedagogy
The Mystery of the Failing Jobs: Insights from Operational Data from Two University-Wide Computing Systems
Creators: name: Kumar, Rakesh
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Performance evaluation
Digital processor architectures
Other information and computing sciences not elsewhere classified
Distributed computing and systems software not elsewhere classified
Distributed systems and algorithms

description: Node downtime and failed jobs in a computing cluster translate into wasted resources and user dissatisfaction. Therefore understanding why nodes and jobs fail in HPC clusters is essential. This paper provides analyses of node and job failures in two university-wide computing clusters at two Tier I US research universities. We analyzed approximately 3.0M job execution data of System A and 2.2M of System B with data sources coming from accounting logs, resource usage for all primary local and remote resources (memory, IO, network), and node failure data. We observe different kinds of correlations of failures with resource usages and propose a job failure prediction model to trigger event-driven checkpointing and avoid wasted work. We provide generalizable insights for cluster management to improve reliability, such as, for some execution environments local contention dominates, while for others system-wide contention dominates.
sj-pdf-1-cjk-10.1177_20543581211033496 – Supplemental material for Expanding the Deceased Donor Pool in Manitoba Using Hepatitis C-Viremic Donors: Program Report
Creators: name: Cuvelier, Susan
name: Van Caeseele, Paul
name: Kadatz, Matthew
name: Peterson, Kathryn
name: Sun, Siyao
name: Dodd, Nancy
name: Werestiuk, Kim
name: Koulack, Joshua
name: Nickerson, Peter
name: Ho, Julie
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-1-cjk-10.1177_20543581211033496 for Expanding the Deceased Donor Pool in Manitoba Using Hepatitis C-Viremic Donors: Program Report by Susan Cuvelier, Paul Van Caeseele, Matthew Kadatz, Kathryn Peterson, Siyao Sun, Nancy Dodd, Kim Werestiuk, Joshua Koulack, Peter Nickerson and Julie Ho in Canadian Journal of Kidney Health and Disease
Immigrant Students and Educational Systems. Cross-Country Evidence from PISA 2006
Creators: name: MURAT, Marina Giovanna
name: FERRARI, Davide
name: FREDERIC, Patrizio
Publisher: name: Dipartimento di Economia Politica - Universit� di Modena e Reggio Emilia
Year: 2012

description: Using data from PISA 2006 on 29 countries, this paper analyses immigrant school gaps
(difference in scores between immigrants and natives) and focuses on tracking and comprehensive
educational systems. Results show that the wider negative gaps are present where tracking is sharp
and less frequently in countries with comprehensive schooling. In both cases, negative gaps are
concentrated in continental Western Europe, where they are also often related to immigrants and
natives attending different schools, or are significant within schools.
Molecular phylogeny of a novel human adenovirus type 8 strain causing a prolonged, multi-state keratoconjunctivitis epidemic in Germany
Creators: name: Hage, Elias
name: Espelage, Werner
name: Eckmanns, Tim
name: Lamson, Daryl M.
name: Pantó, Laura
name: Ganzenmueller, Tina
name: Heim, Albert
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: 610 Medizin

description: The German infectious disease surveillance system revealed an increase of epidemic keratoconjunctivitis (EKC) from an average of 320 cases/year (2001 to 2010) up to 2146 and 1986 cases in 2012 and 2013, respectively. From November 2011 until December 2013 (epidemic period) 85% of typed isolates were human adenovirus type 8 (HAdV-D8), whereas only low level circulation (19%) of HAdV-D8 was observed outside the epidemic period. In order to investigate whether a novel monophyletic HAdV-D8 strain prevailed during the epidemic period, complete genomic sequences of 23 HAdV-D8 isolates were generated by deep sequencing and analyzed phylogenetically. For comparison, eight HAdV-D8 isolates from outside the epidemic period were sequenced. HAdV-D8 isolates of the epidemic period had a very high sequence identity of at least 99.9% and formed a monophyletic cluster with two subclusters. A single outlier was closely related to HAdV-D8 strains isolated prior to the epidemic period. Circulation of the epidemic strain was detected as early as 2010 but not after the epidemic period in 2014. In conclusion, molecular phylogeny of complete genomic sequences proved a monophyletic HAdV-D8 epidemic. However, co-circulation of other HAdV types as well as better reporting may have contributed to the huge increase of reported cases.
Effect of an Unobtrusive and Low-Cost Nudge on Food Choice Behavior of Food Pantry Clients
Creators: name: Echols, Brittni
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other agricultural, veterinary and food sciences not elsewhere classified

description: Understanding the effect of food insecurity of vulnerable individuals is necessary to develop strategies for improving lives of those individuals. In this study I explore the effect of a low-cost, unobtrusive intervention on food pantry clients’ choice of healthier food items at a local food pantry. A cross-sectional study was conducted at a food pantry in the Midwest U.S. using the randomized controlled trial method. Participants in the intervention group received a nutrition ranking information about the food items in the pantry during their visit. Both the intervention and control groups reported their food selections. Additionally, client demographic information was collected in surveys. Data were collected from October 2018 to January 2019. A total of 615 adults were recruited and randomized for the nutrition ranking intervention (n=300) and control group (n=315). Multiple linear regression models were used to predict the outcomes of the intervention while controlling for demographic characteristics such as age, gender, household size, and education level. There was no significant response to the nutritional ranking intervention as it appears that the intervention was ineffective at changing behavior. Results suggest that future studies are needed to determine a low-cost intervention for food pantry clients during their short time at the food pantry.
Detecting multidimensional clustering across EU regions. Focus on R&I smart specialisation strategies and on socio-economic and demographic conditions
Creators: name: RUSSO, Margherita
name: PAVONE, PASQUALE
name: PAGLIACCI, Francesco
name: RIGHI, Simone
name: Giorgi, A.
Publisher: name: Dipartimento di Economia Marco Biagi - Universit� di Modena e Reggio Emilia
Year: 2019

description: This paper applies multidimensional clustering of EU-28 regions to identify similar specialisation strategies and socioeconomic characteristics. It builds on an original dataset where the EU-28 regions are classified according to their socioeconomic and demographic features and to the strategic priorities outlined in their research and innovation smart specialisations strategy (RIS3). The socioeconomic and demographic classification associates each region to one categorical variable (with 19 modalities), while the classification of the RIS3 priorities clustering was performed separately on ?descriptions? (21 Boolean categories) and ?codes? (11 Boolean Categories) of regions? RIS3. Three techniques of clustering have been applied: Infomap multilayer algorithm, Correspondence Analysis plus Cluster Analysis and cross tabulation. The most effective clustering, in terms of both the characteristics of the data and the emerging results, is that obtained on the results of the Correspondence Analysis. By contrast, due to the very dense network induced by the data characteristics, the Infomap algorithm does not produce significant results. Finally, cross tabulation is the most detailed tool to identify groups of regions with similar characteristics. In particular, in the paper we present an application of cross tabulation to focus on the regions investing in sustainable development priorities. Policy implications of methods implemented in this paper are discussed as a contribution to the current debate on post-2020 European Cohesion Policy, which aims at orienting public policies toward the reduction of regional disparities and the enhancement of complementarities and synergies within macroregions.
Housing Market Shocks in Italy: a GVAR Approach
Creators: name: CIPOLLINI, Andrea
name: Parla, F.
Publisher: name: Dipartimento di Economia Marco Biagi - Universit� di Modena e Reggio Emilia
Year: 2018

description: In this paper, we use a Global Vector Autoregression (GVAR) model to assess the spatio-temporal mechanism of house price spillovers, also known as ?ripple effect?, among 93 Italian provincial housing markets, over the period 2004 ? 2016. In order to better capture the local housing market dynamics, we use data not only on house prices but also on transaction volumes. In particular, we focus on estimating, to what extent, exogenous shocks, interpreted as negative housing demand shocks, arising from 10 Italian regional capitals, impact on their house prices and sales and how these shocks spill over to neighbours housing markets. The negative housing market demand shock hitting the GVAR model is identified by using theory-driven sign restrictions. The spatio-temporal analysis carried through impulse response functions shows that there is evidence of a ?ripple effect? mainly occurring through transaction volumes.
Innovation in education and re-industrialisation in Europe
Creators: name: MENGOLI, PAOLA
name: RUSSO, Margherita
Publisher: name: Dipartimento di Economia Politica - Universit� di Modena e Reggio Emilia
Year: 2014

description: In this paper we discuss innovations in education, with a focus on those oriented towards knowledge-driven re-industrialisation in Europe. We first introduce the specific education needs for re-industrialisation with regard (a) to young people?s knowledge and skills in science, technology, engineering and mathematics (STEM), and (b) to specific training needs of mid-level technicians. Then we propose the adoption of a context-based approach to place science and technology within young people?s daily lives and to promote links between science, technology and society. In particular, we propose the use of robotics labs to improve context-based approach to technology education. We suggest action-research as a feasible practice to boost bottom-up changes in teaching and learning activities, and we focus on the university initiative Officina Emilia as an exemplar of such actions, as the initiative involves university researchers, manufacturing and services companies, education agencies, civil society. The paper offers some concluding remarks on two main ingredients that can support a more appropriate set of education and training activities to enhance knowledge-driven re-industrialisation: first, the need to allow the emergence of hybrid places fostering innovation, with the involvement of different agents; second, the robotics labs, among others, as a means to foster a multidisciplinary perspective, crucial for the new challenges that education faces in supporting re-industrialization.
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature
Creators: name: Peck, Michael W.
name: Smith, Theresa J.
name: Anniballi, Fabrizio
name: Austin, John W.
name: Bano, Luca
name: Bradshaw, Marite
name: Cuervo, Paula
name: Cheng, Luisa W.
name: Derman, Yagmur
name: Dorner, Brigitte
name: Fisher, Audrey
name: Hill, Karen K.
name: Kalb, Suzanne R.
name: Korkeala, Hannu
name: Lindström, Miia
name: Lista, Florigio
name: Lúquez, Carolina
name: Mazuet, Christelle
name: Pirazzini, Marco
name: Popoff, Michel R.
name: Rossetto, Ornella
name: Rummel, Andreas
name: Sesardic, Dorothea
name: Singh, Bal Ram
name: Stringer, Sandra C.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2017
Subjects: subject: Clostridium botulinum
subject: botulinum
subject: botulism
subject: neurotoxins
subject: subtypes
subject: guidelines
subject: nomenclature
subject: 610 Medizin

description: Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.
ALGORITHM TO DEVELOP A MODEL PROVIDING SECURITY AND SUSTAINABILITY FOR THE U.S. INFRASTRUCTURE BY PROVIDING INCREMENTAL ELECTRICAL RESTORATION AFTER BLACKOUT
Creators: name: Shull, Casey Allen
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Performance evaluation

description: Is North America vulnerable to widespread electrical blackout from natural or man-made disasters? Yes. Are electric utilities and critical infrastructure (CI) operators prepared to maintain CI operations such as, hospitals, sewage lift stations, food, water, police stations etc., after electrical blackout to maintain National security and sustainability? No. Why? Requirements to prioritize electrical restoration to CI do not exist as a requirement or regulation for electrical distribution operators. Thus, the CI operators cannot maintain services to the public without electricity that provides power for the critical services to function. The problem is that electric utilities are not required to develop or deploy a prioritized systematic plan or procedure to decrease the duration of electrical outage, commonly referred to as blackout. The consequence of local blackout to CI can be multi-billion-dollar financial losses and loss of life for a single outage event attributed to the duration of blackout. This study utilized the review of authoritative literature to answer the question: “Can a plan be developed to decrease the duration of electrical outage to critical infrastructure”. The literature revealed that electric utilities are not required to prioritize electrical restoration efforts and do not have plans available to deploy minimizing the duration of blackout to CI. Thus, this study developed a plan and subsequent model using Model Based System Engineering (MBSE) to decrease the duration of blackout by providing incremental electrical service to CI.
Il costo della crisi in termini di salute mentale: il caso di Modena
Creators: name: ADDABBO, Tindara
name: SARTI, ELENA
name: STARACE, FABRIZIO
Publisher: name: Fondazione Marco Biagi
Year: 2015

description: La grande recessione ha causato costi tangibili in termini di tagli nell?occupazione e nella riduzione del reddito nei Paesi Europei. L?incertezza derivante dalla perdita del lavoro e l?espandersi di condizioni lavorative precarie sono state individuate in letteratura come possibili determinanti di una precaria salute mentale. La letteratura esistente sulla disoccupazione e la salute mentale mostra chiaramente una riduzione del benessere individuale durante il periodo di disoccupazione e un miglioramento dello stesso una volta ritrovato il lavoro. Questo studio mira ad identificare la relazione esistente tra lo stato di occupato e la salute mentale nella provincia di Modena che � stata colpita, oltre che dalla crisi economica, anche dal terremoto nell?anno 2012. I risultati, basati sull?analisi di due indagini sulle condizioni socio-economiche delle famiglie di Modena (ICESmo2 riferita all?anno 2006 e ICESmo3 riferita all?anno 2012), indicano un effetto negativo sulla salute mentale provocato dalla crisi, con una dimensione pi� grande di quella osservata nella media italiana. Inoltre, si osserva una riduzione dell?indice di salute mentale pi� accentuata per le donne e si registra un effetto negativo della disoccupazione sulla salute mentale e la residenza in un?area colpita dal terremoto.
Additional file 6 of PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p
Creators: name: Lu, Xiaoxiao
name: Zhu, Qingyun
name: Du, Hong
name: Gu, Mingjun
name: Li, Xiangqi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 6