cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge
Creators: name: Minai, M.
name: Mascola, J.R.
name: Abiona, O.M.
name: Boyoglu-Barnum, S.
name: Bock, K.W.
name: Sullivan, N.J.
name: Carfi, A.
name: Baric, R.S.
name: Loomis, R.J.
name: Schäfer, A.
name: Nagata, B.M.
name: Moliva, J.I.
name: Graham, B.S.
name: Chang, L.A.
name: Werner, A.
name: Morabito, K.M.
name: DiPiazza, A.T.
name: Edwards, D.K.
name: Leist, S.R.
name: Corbett, K.S.
name: Ruckwardt, T.J.
name: Dinnon, K.H., III
name: Phung, E.
name: Alvarado, G.S.
name: Moore, I.N.
Publisher: name: Cell Press
Year: 2021

description: Vaccine-associated enhanced respiratory disease (VAERD) was previously observed in some preclinical models of SARS and MERS coronavirus vaccines. We used the SARS-CoV-2 MA10 mouse model of acute lung injury to evaluate the immune response and potential for immunopathology in animals vaccinated with research-grade mRNA-1273. Whole-inactivated virus or heat-denatured spike protein subunit vaccines with alum designed to elicit low-potency antibodies and Th2-skewed CD4+ T cells resulted in reduced viral titers and weight loss postchallenge, but more severe pathological changes in the lung compared to saline-immunized animals. In contrast, a protective dose of mRNA-1273 induced favorable humoral and cellular immune responses that protected from viral replication in the upper and lower respiratory tract upon challenge. A subprotective dose of mRNA-1273 reduced viral replication and limited histopathological manifestations compared to animals given saline. Overall, our findings demonstrate an immunological signature associated with antiviral protection without disease enhancement following vaccination with mRNA-1273.
New effective differential Nullstellensatz
Creators: name: Gustavson, Richard
name: Kondratieva, Marina
name: Ovchinnikov, Alexey
Publisher: name: arXiv
Year: 2014
Subjects: subject: Commutative Algebra (math.AC)
subject: Symbolic Computation (cs.SC)
subject: Algebraic Geometry (math.AG)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We show new upper and lower bounds for the effective differential Nullstellensatz for differential fields of characteristic zero with several commuting derivations. Seidenberg was the first to address this problem in 1956, without giving a complete solution. The first explicit bounds appeared in 2009 in a paper by Golubitsky, Kondratieva, Szanto, and Ovchinnikov, with the upper bound expressed in terms of the Ackermann function. D'Alfonso, Jeronimo, and Solernó, using novel ideas, obtained in 2014 a new bound if restricted to the case of one derivation and constant coefficients. To obtain the bound in the present paper without this restriction, we extend this approach and use the new methods of Freitag and León Sánchez and of Pierce from 2014, which represent a model-theoretic approach to differential algebraic geometry.
Focus on Low-Cost Light-Weight Upper Stage within ESAS Future Launchers Preparatory Programme (FLPP)
Creators: name:  K. UNDERHILL
name:   A. FLOCK
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: FUTURE SPACE OPERATIONS

description: With a 1:1 impact on payload capacity, improvements on a launcher upper stage result in significant improvements in launcher performance. Starting in 2018 work has been ongoing in FLPP NEO on an optimised upper stage for an evolution of Ariane 6, where configuration studies have shown a payload performance gain of over two tonnes for GTO missions is achievable, whilst also reducing the recurring cost of the stage. The work on the upper stage is integrated in approach, working across the FLPP System/Services Demonstrators Technologies domains. An upper stage system study the Multifunctional Upper Stage Express (MUSE) project, linked to launcher system activities carried out in parallel in FLPP had the initial important task of identifying an upper stage concept, architecture and applicable technologies that would bring significant payload performance gains in future evolutions of Ariane 6. By the end of 2020, an upper stage concept complying to the High-Level Requirements provided by FLPP had been selected, including estimated performance gains and recurring cost reductions and providing outlines of all sub-systems. The selected configuration makes use of the new design possibilities allowed by the application of carbon-fibre reinforced plastic (CFRP) tanks and structures, which are matured in separate FLPP demonstrator and technology projects. The system-level analysis will continue as work proceeds on technology maturation projects where each technology has been selected for maturation due to the quantified system impact and where all technology maturation results feed into an ever more consolidated upper stage design. The upper stage system will also continue working on the functional simplification of the upper stage including the transfer of versatility to kick-stages, the search for safe and low performance impact de-orbitation manoeuvres and contributing to an overall understanding on future launcher needs i.e. linked to new mission profiles. All technology areas of the upper stage are matured across various projects within FLPP, all linked to the system analysis, providing the functional requirements for the sub-systems and technologies and permanently evaluating the system-level impact including recurring cost and therefore the interest of the application of the technologies. This paper will present the current status of results from the MUSE project as well as associated technology and demonstrator projects such as the PHOEBUS/COMET/PACE CFRP upper stage structural demonstrators, the LunaNova kick-stage, the latest ETID engine demonstrator findings in applying additive manufacturing to propulsion systems and the FLASH technology maturation project in the structures, functional propulsion system and avionics domains.
(501247) _____ ? [Hughes]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Towards a numerical multi-fidelity strategy for unsteady aerodynamics studies of reusable launch vehicles: Application to Ariane Next
Creators: name:  P. WEISS
name:   S. DECK
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: FLIGHT PHYSICS
COMPUTATIONAL FLUID DYNAMICS

description: Reusable launch vehicles imply the use of innovative numerical multi-fidelity strategies to allow the proper prediction of the related unsteady aerodynamic properties. In that view, a numerical workflow denoted as Zonal Immersed Boundary Conditions (ZIBC) has been developed and successfully applied to full space launcher models namely Ariane 5 as well as a Ariane 6 PPH. Such a framework permits a global survey of the timeline of the flight of a sub-scale Ariane Next configuration with a particular focus on the descent based on URANS and ZDES computations. In practice, the main cylindrical body with aft and forward axisymmetric skirts are modelled using a classical body-fitted (BF) approach. All other technological details are taken into account by the local introduction of source terms (namely immersed boundary conditions (IBC)) as in Weiss and Deck or Manueco et al. The robustness and the accuracy of the approach provides a rapid overview of the instantaneous coherent structures in the turbulent flow. The salient features of the flow topology are also depicted on the basis of first- and second-order statistics for cases with different physical conditions from the transonic to the supersonic regimes in a Mach number range between M = 0.7 and 2 with incidence. Finally, the time-history of the fluctuating pressure is analysed.
ИНДИВИДУЛЬНЫЙ ПОДХОД ЛЕЧЕНИЯ ПАЦИЕНТА С ЗАКРЫТЫМ ВНУТРИСУСТАВНЫМ ПЕРЕЛОМОМ ПРОКСИМАЛЬНОГО ОТДЕЛА БОЛЬШЕБЕРЦОВОЙ КОСТИ В СОЧЕТАНИИ С ПОВРЕЖДЕНИЕМ МЯГКОТКАННЫХ СТРУКТУР КОЛЕННОГО СУСТАВА
Creators: name: Бальжинимаев Д.Б.
name: Михайлов И.Н.
Publisher: name: Политравма
Year: 2020
Subjects: внутрисуставной перелом проксимального эпиметадиафиза большеберцовой кости; передняя крестообразная связка; коленный сустав; пластика ПКС

description: Закрытый внутрисуставной перелом проксимального отдела большеберцовой кости в сочетании с разрывом передней крестообразной связки коленного сустава является серьезной хирургической патологией. Несвоевременная диагностика и неправильное лечение этих травм часто приводят к дальнейшей инвалидизации пациентов. Цель работы – показать результат индивидуального подхода хирургического лечения пациента с закрытым внутрисуставным переломом проксимального эпиметадиафиза большеберцовой кости со смещением костных отломков в сочетании с полным разрывом ПКС, лоскутным разрывом латерального и медиального менисков правого коленного сустава. Материалы и методы. На начальном этапе одновременно с внутрисуставным переломом проксимального отдела большеберцовой кости нами было выявлено повреждение ПКС коленного сустава и была определена дальнейшая тактика лечения, которая заключалась в двухэтапности выполнения. В качестве материала для восстановления утраченной ПКС нами было изначально спланировано использование собственного сухожилия длинной малоберцовой мышцы, что имеет немаловажное значение в дальнейшей активной реабилитации пациента после операции, так как анатомически длинная малоберцовая мышца располагается вне проекционной области коленного сустава. Первым этапом пациентке был выполнен погружной остеосинтез проксимального эпиметадиафиза правой большеберцовой кости блокируемой пластиной. Вторым этапом была выполнена артроскопическая аутотендопластика ПКС аутотрансплантатом из ½ сухожилия длинной малоберцовой мышцы, моделирующая парциальная резекция обеих менисков правого коленного сустава. Срок наблюдения составил 2 года после операции. Результаты. Восстановление первым этапом только целостности костных структур позволило исключить возможные нежелательные исходы: формирование ложного сустава или дефектов костной ткани в проксимальном отделе большеберцовой кости и неправильную ориентацию каналов планируемого трансплантата, а также восстановить плато большеберцовой кости и на этапе реабилитации восстановить амплитуду движений в коленном суставе. На втором этапе реконструкция передней крестообразной связки по выбранной тактике позволила добиться стабильности коленного сустава и восстановить полную функцию коленного сустава. Выводы. Выбранная тактика двухэтапного лечения у данной пациентки позволила добиться восстановления полноценной функции в коленном суставе и улучшить качество ее жизни.
title: Ultrasound guided corticosteroid injections for de Quervain’s tenosynovitis
Creators: name: Hillyard , Katherine
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Drugs / Reactions
subject: Audit and standards
subject: Ultrasound
subject: Musculoskeletal soft tissue

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: De Quervain’s tenosynovitis is a painful condition of the radial aspect of the wrist affecting 0.5% of men and 1.3% of women(1). Thickening of the first extensor compartment sheath, which surrounds the abductor pollicis longus and extensor...
title: Institutioneller Rassismus in der Justiz
Creators: name: Beck, Hannah Katinka
name: Alwan, Hilal
name: Schmieta, Paula
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
Topologically Induced Fermion Parity Flips in Superconductor Vortices
Creators: name: Teo, Jeffrey C. Y.
name: Khan, Mayukh Nilay
name: Vishveshwara, Smitha
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A highlighting feature of Majorana bound states in two-dimensional topological superconductors is that they gain a phase factor of $π$ upon being orbited by a vortex. This work focuses on the vortex degree of freedom itself and demonstrates that the change in the Majorana state is accompanied by a fermion parity change within the vortex. Such a parity flip is interpreted as a higher dimensional analog of the fermion parity pump mechanism in superconducting wires as well as through general topological arguments. It is demonstrated in terms of level crossings in three different situations - in i) spin-triplet paired superconductors, and in proximity-induced superconducting systems involving ii) quantum spin Hall-ferromagnet hybrids and iii) Chern insulators.
description: 6 pages, 3 figures
(501248) Cuthbert Newington Hughes Johnson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Drug-induced liver injury associated with lopinavir-ritonavir in patients with COVID-19: a disproportionality analysis of U.S. food and drug administration adverse event reporting system (FAERS) data
Creators: name: Li, Xiaotong
name: Kinlaw, Alan C.
name: Barnes, Edward L.
name: Wang, Tiansheng
name: Zhou, Liyuan
name: Yang, Jeff Y.
name: Tang, Huilin
name: Moon, Andrew M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Background Liver injury has been documented independently in novel coronavirus disease 2019 (COVID-19) patients and patients treated with lopinavir-ritonavir. Objective to investigate the drug-induced liver injury associated with lopinavir-ritonavir among the patients with COVID-19. Methods We conducted a disproportionality analysis of US Food and Drug Administration Adverse Event Reporting System (FAERS) between 2020Q1 and 2021Q1 to evaluate the association between lopinavir-ritonavir and risk of drug-induced liver injury (or severe drug-induced liver injury) and calculated their reporting odds ratios (RORs) with 95% confidence intervals (CIs). Results A total of 3,425 cases of drug-induced liver injury were reported in 19,782 patients with COVID-19. The ROR for drug-induced liver injury was 2.99 (2.59–3.46), 3.16 (2.68–3.73), and 5.39 (4.63–6.26) when comparing lopinavir-ritonavir with all other drugs, hydroxychloroquine/chloroquine only, and remdesivir, respectively. For severe drug-induced liver injury, RORs for lopinavir-ritonavir provided evidence of an association compared with all other drugs (3.98; 3.15–5.05), compared with hydroxychloroquine/chloroquine only (5.33; 4.09–6.94), and compared with remdesivir (3.85; 3.03–4.89). Conclusions In the FAERS, we observed a disproportional signal for drug-induced liver injury associated with lopinavir-ritonavir in patients with COVID-19.
New Gastrointestinal Symptoms Are Common in Inflammatory Bowel Disease Patients With COVID-19: Data From an International Registry
Creators: name: Reinisch, Walter
name: Agrawal, Manasi
name: Colombel, Jean-Frederic
name: Kappelman, Michael D
name: Zhang, Xian
name: Brenner, Erica J
name: Ungaro, Ryan C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Coronavirus disease 2019 (COVID-19) can cause gastrointestinal (GI) symptoms. A prior meta-analysis suggested that up to 17.6% of COVID-19 patients have GI symptoms. Data are conflicting on the association of GI symptoms with COVID-19 outcomes, with some reports suggesting worse prognosis among those with GI symptoms while others finding improved outcomes. There are limited data on COVID-19 and GI symptoms among inflammatory bowel disease (IBD) patients. A single-center study of 80 IBD patients with COVID-19 observed that they were more likely to present with abdominal pain and diarrhea than non-IBD controls. In addition, a prior systematic review on just over 400 patients found nearly one-quarter of IBD patients with COVID-19 had diarrhea.6 Using a large, international database, we aimed to describe new onset GI symptoms and their association with clinical outcomes in patients with IBD who develop COVID-19.
Reentrant transition in coupled noisy oscillators
Creators: name: Kobayashi, Yasuaki
name: Kori, Hiroshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: We report on a novel type of instability observed in a noisy oscillator unidirectionally coupled to a pacemaker. Using a phase oscillator model, we find that, as the coupling strength is increased, the noisy oscillator lags behind the pacemaker more frequently and the phase slip rate increases, which may not be observed in averaged phase models such as the Kuramoto model. Investigation of the corresponding Fokker-Planck equation enables us to obtain the reentrant transition line between the synchronized state and the phase slip state. We verify our theory using the Brusselator model, suggesting that this reentrant transition can be found in a wide range of limit cycle oscillators.
description: 16 pages, 7 figures
Household transmission of SARS-CoV-2 in the United States: living density, viral load, and disproportionate impact on communities of color
Creators: name: Powers, Kimberly A
name: Smith, Judy
name: Lin, Feng-Chang
name: Litel, Christy
name: Tompkins, Kathleen
name: Premkumar, Lakshmanane
name: Rubinstein, Rebecca
name: Khan, Salman
name: Basham, Christopher
name: Chhetri, Srijana B
name: Churiwal, Mehal
name: Claman, Faith
name: Muller, Meredith S
name: Mollan, Katie
name: Rapp, Tyler
name: Lin, Kelly D
name: Lin, Jessica T
name: Cerami, Carla
name: Wohl, David
name: Popkin-Hall, Zachary R
name: Whittelsey, Maureen
name: Juliano, Jonathan J
name: Zhang, Haoming
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Households are hotspots for SARS-CoV-2 transmission. In the US, the COVID-19 pandemic has had a disproportionate impact on communities of color. Between April-October 2020, the CO-HOST prospective cohort study enrolled 100 COVID-19 cases and 208 of their household members in North Carolina, including 44% who identified as Hispanic or non-white. Households were enrolled a median of 6 days from symptom onset in the index case. Incident secondary cases within the household were detected by quantitative PCR of weekly nasal swabs (days 7, 14, 21) or by seroconversion at day 28.Excluding 73 household contacts who were PCR-positive at baseline, the secondary attack rate among household contacts was 32% (33/103, 95% CI 22%-44%). The majority of cases occurred by day 7, with later cases confirmed as household-acquired by viral sequencing. Infected persons in the same household had similar nasopharyngeal viral loads (ICC=0.45, 95% CI 0.23-0.62). Households with secondary transmission had index cases with a median viral load that was 1.4 log10 higher than households without transmission (p=0.03) as well as higher living density (>3 persons occupying <6 rooms) (OR 3.3, 95% CI 1.02-10.9). Minority households were more likely to experience high living density and had a higher risk of incident infection than did white households (SAR 51% vs. 19%, p=0.01).Household crowding in the context of high-inoculum infections may amplify the spread of COVID-19, potentially contributing to disproportionate impact on communities of color.
Effects of Zero Net Mass Flux devices on a Next-Generation Tiltrotor airplane in subsonic regime by numerical simulation at high Reynolds number
Creators: name:  A. MAROUF
name:   A. CHOUIPPE
name:   Y. HOARAU
name:   J.B. VOS
name:   D. CHARBONNIER
name:   A. GEHRI
name:   D.H. TRUONG
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: FLOW CONTROL
AEROSPACE

description: The flow around the Leonardo Next-Generation Civil Tiltrotor platform (NextGenCTR or NGCTR) is examined in the context of the European research programme CleanSky AFC4TR Active Flow Control for Tilt-Rotor aircraft https://www.afc4tr.eu N 886718. The objective of the AFC4TR project is to investigate the use of Active Flow Control using pulsed air blowing devices with Zero Net Mass Flux (ZNMF) to control the vortical flow around wings. Three-dimensional simulations are carried out using the Navier-Stokes Multi-Block solver NSMB ([1], [2]) at high Reynolds number and near stall angle of attack of near stall condition corresponding to the take-off configuration. The flow is characterized by the presence of corner vortices formed in junctions located near the fuselage and the nacelle which results in a loss of the aerodynamic performances (decrease of lift, increase of drag). The flow is separated around the aileron and causes a considerable loss in its efficiency during the airplane maneuverability. This study examines these corner vortices using adapted turbulence models to capture their correct sizes. The rotation of the engine propellers is also considered due to the unsteady periodic effects produced on the pressure distribution of the wing and fuselage surfaces leading to an unstable evolution of these corner vortices. The study examines the effects of the Zero Net Mass Flux devices by producing a synthetic jet using a sinusoidal oscillating membrane or a piston to alternatingly force the fluid through an orifice into the external flow field. These devices (also known as synthetic jet actuators) do not require external fluid supply of complex piping, in addition to their low cost and small size. This work focuses on the optimization of different parameters as the frequency of actuation, the velocity amplitude, the angle of the jet and the dimensions of the actuators to better reattach the flow through the enhancement of the mixing and momentum transfer within the boundary layer to explore the capabilities of the Active Flow Control (AFC) applicability to a full-scale aircraft configuration at real flight conditions. References [1] Y. Hoarau, D. Pena, J. B. Vos, D. Charbonnier, A. Gehri, M. Braza, T. Deloze, and E. Laurendeau. Recent Developments of the Navier Stokes Multi Block (NSMB) CFD solver. In 54th AIAA Aerospace Sciences Meeting, 2016. URL 10.2514/6.2016-2056. [2] J. B. Vos, A. Rizzi, A. Corjon, E. Chaput, and E. Soinne. Recent advances in aerodynamics inside the NSMB (Navier Stokes Multi Block) consortium. In 36th AIAA Aerospace Sciences Meeting and Exhibit, 1998. URL https://doi.org/10.2514/6.1998-225.
(501239) ____ ? [Brereton]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
РЕАБИЛИТАЦИОННЫЙ ПОТЕНЦИАЛ ЛИЧНОСТИ И ФУНКЦИОНАЛЬНАЯ НЕЗАВИСИМОСТЬ ЛИЦ С ТРАВМАТИЧЕСКОЙ БОЛЕЗНЬЮ СПИННОГО МОЗГА
Creators: name: Хохлова О.И.
Publisher: name: Политравма
Year: 2020
Subjects: травматическое повреждение спинного мозга; реабилитация; функциональная независимость; повседневная активность; реабилитационный потенциал личности

description: Решение одной из основных задач реабилитации лиц, переживших травму спинного мозга, – повышение независимости в повседневной жизни от окружающих – невозможно без учета личностных ресурсов. Однако фактические данные, описывающие связь между этими аспектами реабилитации, отсутствуют. Цель исследования – изучить взаимосвязи степени функциональной независимости и уровня реабилитационного потенциала личности у лиц с травматической болезнью спинного мозга (ТБСМ). Материал и методы. Обследовано 32 пациента с ТБСМ клиники ФГБУ ННПЦ МСЭ и РИ Минтруда России с давностью травмы не более трех лет. Степень функциональной независимости оценивали с помощью шкал SCIM-III (Измеритель независимости при повреждениях спинного мозга, версия 3) и FIM (Измеритель функциональной независимости). Для оценки реабилитационного потенциала личности использовали методику И.Ю. Кулагиной, Л.В. Сенкевич. Результаты. У половины пациентов с ТБСМ наблюдались низкие показатели функциональной независимости (SCIM-III – ниже 44 баллов, FIM – 71), у 93,7 % – средние или высокие значения общего уровня реабилитационного потенциала личности. Величина последнего определялась высокими уровнями коммуникативного компонента, но не коррелировала с ними. При этом установлены прямые корреляционные связи между общим уровнем реабилитационного потенциала личности и значениями мотивационного, самооценочного, эмоционального компонентов и внутренней картины болезни, а также показателями функциональной независимости. У лиц с параплегией обнаружена отрицательная корреляционная связь между уровнем коммуникативного компонента и суммой баллов по шкале FIM (коэффициент ранговой корреляции Спирмена ρ = -0,604, р = 0,017), что свидетельствует о негативном влиянии высокого коммуникативного компонента на результаты реабилитации, связанного с чрезмерной опекой, способствующей формированию зависимости от ухаживающих лиц. Заключение. Усилия, направленные на увеличение уровней компонентов общего реабилитационного потенциала личности (мотивационного, самооценочного, эмоционального и внутренней картины болезни) и на рациональное использование высокого коммуникативного компонента, могут повысить эффективность реабилитации и степень функциональной независимости лиц с ТБСМ.
Workshop of the World: Uniting Community and Creating Opportunity through Adaptive Reuse
Creators: name: Vogtman, John
Publisher: name: Digital Repository at the University of Maryland
Year: 2017
Subjects: subject: Architecture
subject: Abandoned
subject: Adaptive
subject: Community
subject: Industry
subject: Philadelphia
subject: Reuse

description: An abundance of abandoned structures exist in post-industrial cities throughout the United States. Many of these structures have significant historical and cultural ties which contribute to the identity of the city. This thesis seeks to examine how these remnants can be adaptively reused or revalued to strengthen and regenerate communities while retaining elements of the character and history of the site and building. Using the city of Philadelphia and the Delaware Riverfront as a case study, it identifies a range of possibilities and focuses on the PECO Delaware Generating Station as a final design proposal.
Additional file 1 of Relationships between accelerometry and general compensatory movements of the upper limb after stroke
Creators: name: Barth, Jessica
name: Joeseph W. Klaesner
name: Lang, Catherine E.
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Table.The suppplemental table is the compensatory movement scoring checklist. Items to create this checklist were synthesized from the following assessments, Reaching Performacne Scale (1), Upper Extremity Fugl- Meyer (2), Wolf Motor Function Test, (3) Action Research Arm Test, (4) Chedoke McMasters, (5) Stroke Rehabiliation Assessment of Movement (STREAM), (6) Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES), (7) Motor Assessment Scale (MAS), (8) and Quantative assessment of upper extremity function. (9) Compensatory behaviors on the checklist included movements at the head, trunk, shoulder,elbow, forearm, wrist, fingers and fluidity/movement. Compensations were scored as present or absent from the videotaped completion of the ARAT.
Identification of a novel inflamed tumor microenvironment signature as a predictive biomarker of bacillus Calmette-Guérin immunotherapy in non-muscle-invasive bladder cancer
Creators: name: Solit, D.B.
name: Furberg, H.
name: Sun, X.
name: Olshan, A.F.
name: Kirk, E.L.
name: Troester, M.A.
name: Iyer, G.
name: Damrauer, J.S.
name: Bochner, B.H.
name: Al-Ahmadie, H.A.
name: Smith, M.A.
name: Dalbagni, G.
name: Roell, K.R.
name: Hoadley, K.A.
name: Benefield, H.C.
name: Kim, W.Y.
name: Wobker, S.E.
name: Pietzak, E.J.
name: Nielsen, M.E.
name: Milowsky, M.I.
Publisher: name: American Association for Cancer Research Inc.
Year: 2021

description: Purpose: Improved risk stratification and predictive biomarkers of treatment response are needed for non-muscle-invasive bladder cancer (NMIBC). Here we assessed the clinical utility of targeted RNA and DNA molecular profiling in NMIBC. Experimental Design: Gene expression in NMIBC samples was profiled by NanoString nCounter, an RNA quantification platform, from two independent cohorts (n = 28, n = 50); targeted panel sequencing was performed in a subgroup (n = 50). Gene signatures were externally validated using two RNA sequencing datasets of NMIBC tumors (n = 438, n = 73). Established molecular subtype classifiers and novel gene expression signatures were assessed for associations with clinicopathologic characteristics, somatic tumor mutations, and treatment outcomes. Results: Molecular subtypes distinguished between low-grade Ta tumors with FGFR3 mutations and overexpression (UROMOL-class 1) and tumors with more aggressive clinicopathologic characteristics (UROMOL-classes 2 and 3), which were significantly enriched with TERT promoter mutations. However, UROMOL subclasses were not associated with recurrence after bacillus Calmette-Guérin (BCG) immunotherapy in two independent cohorts. In contrast, a novel expression signature of an inflamed tumor microenvironment (TME) was associated with improved recurrence-free survival after BCG. Expression of immune checkpoint genes (PD-L1/PD-1/CTLA-4) was associated with an inflamed TME, but not with higher recurrence rates after BCG. FGFR3 mutations and overexpression were both associated with low immune signatures. Conclusions: Assessment of the immune TME, rather than molecular subtypes, is a promising predictive biomarker of BCG response. Modulating the TME in an immunologically “cold” tumor warrants further investigation. Integrated transcriptomic and exome sequencing should improve treatment selection in NMIBC.
title: Multiscale modeling of ferroelectrics with stochastic grain size distribution
Creators: name: Lange, Stephan
name: Ricoeur, Andreas
Publisher: name: Universität Kassel
Year: 2021
Subjects: subject: ferroelectric hysteresis
subject: remanent polarization
subject: remanent strain
subject: condensed method
subject: representative volume element
subject: homogenization
subject: grain size distribution
subject: 500
subject: 620
subject: Ferroelektrikum
subject: Hysterese
subject: Remanenz
subject: Homogenisieren
subject: Korngrößenverteilung
subject: Physikalische Eigenschaft

description: Gefördert im Rahmen eines Open-Access-Transformationsvertrags mit dem Verlag
(501240) Charles Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
National Election Pool Poll # 2006-STELEC-WV: West Virginia Election Day Exit Poll
Creators: name: ABC News
name: Associated Press
name: CBS News
name: CNN
name: Fox News
name: National Election Pool (NEP)
name: NBC News
Publisher: name: Roper Center for Public Opinion Research
Year: 2007

description: For whom did respondent just vote in the Senatorial election (1); respondent/someone in household belongs to a labor union (1); Robert Byrd¿s age interfering with his ability to serve effectively as senator (1); George W. Bush job performance (1); Joe Manchin job performance (1); war in Iraq (1).
title: #39 Targeted Killings: Von Tiergarten bis Teheran
Creators: name: Rau, Daniela
name: Tuchtfeld, Erik
name: Lischewski, Isabel
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 341

description: In den letzten Monaten häufen sich Berichten von targeted killings hochrangiger militärischer und politischer Führungspersonen außerhalb unmittelbarer Kampfgebiete, wie die Tötung von Fuad Schukr, einem Hisbollah-Kommandeur, in Beirut oder von Ismail Haniyya, einem politischen Führer der Hamas, in Teheran. Dabei handelt es sich aber nicht um ein neues Phänomen, ältere Beispiele sind der Berliner Tiergarten-Mord oder auch die Tötung von Osama bin Laden. Welche verschiedenen Gebiete des Völkerrechts bei diesen Tötungen betroffen sind und unter welchen engen Voraussetzungen sie ausnahmsweise zulässig sein können, hat Erik Tuchtfeld mit Kai Ambos besprochen. Im Grundlagenteil konzentriert sich Isabel Lischewski auf das Menschenrecht auf Leben und stellt es in seinen vielfältigen Facetten dar. Nach gut dreieinhalb Jahren Völkerrechtspodcast möchten wir gerne von Euch erfahren, wie wir noch besser werden können und haben deshalb eine kleine Umfrage vorbereitet. Wir freuen uns über jede Rückmeldung! Wie immer sind natürlich Lob, Anmerkungen und Kritik auch an podcast@voelkerrechtsblog.org herzlich willkommen. Abonniert unseren Podcast via RSS, über Spotify oder überall dort, wo es Podcasts gibt. Es gibt die Möglichkeit, auf diesen Plattformen den Völkerrechtspodcast zu bewerten, wir freuen uns sehr über 5 Sterne! Hintergrundinformationen: Ambos/Alkatout, Has ‘Justice Been Done’? The Legality of Bin Laden’s Killing Under International Law, Israel Law Review 2012, 341–366. UN OHCHR, Press Release: Independent experts condemn escalating violence in the Middle East, urge ceasefire and accountability, 2024. Rudolf/Schaller, »Targeted Killing« - Zur völkerrechtlichen, ethischen und strategischen Problematik gezielten Tötens in der Terrorismus- und Aufstandsbekämpfung, 2012. Melzer, Targeted killing in international law, 2008. Eser, Tötung im Krieg: Rückfragen an das Staats- und Völkerrecht, in: Appel/Hermes/Schönberger (Hrsg.), Öffentliches Recht im offenen Staat: Festschrift für Rainer Wahl zum 70. Geburtstag, 2011. Moderation: Erik Tuchtfeld, LL.M (Glasgow) & Daniela Rau Grundlagen: Dr. Isabel Lischewski Interview: Univ.-Prof. Dr. Dr. h.c. Kai Ambos & Erik Tuchtfeld, LL.M (Glasgow) Schnitt: Daniela Rau Credits: The Obama White House, President Obama on Death of Osama bin Laden, 02.05.2011
description: Völkerrechtsblog
Common Origin of 3.55 keV X-Ray Line and Galactic Center Gamma Ray Excess in a Radiative Neutrino Mass Model
Creators: name: Borah, Debasish
name: Dasgupta, Arnab
name: Adhikari, Rathin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We attempt to simultaneously explain the recently observed 3.55 keV X-ray line in the analysis of XMM-Newton telescope data and the galactic center gamma ray excess observed by the Fermi gamma ray space telescope within an abelian gauge extension of standard model. We consider a two component dark matter scenario with tree level mass difference 3.55 keV such that the heavier one can decay into the lighter one and a photon with energy 3.55 keV. The lighter dark matter candidate is protected from decaying into the standard model particles by a remnant $Z_2$ symmetry into which the abelian gauge symmetry gets spontaneously broken. If the mass of the dark matter particle is chosen to be within $31-40$ GeV, then this model can also explain the galactic center gamma ray excess if the dark matter annihilation into $b\bar{b}$ pairs has a cross section of $\langle σv \rangle \simeq (1.4-2.0) \times 10^{-26} \; \text{cm}^3/\text{s}$. We constrain the model from the requirement of producing correct dark matter relic density, 3.55 keV X-ray line flux and galactic center gamma ray excess. We also impose the bounds coming from dark matter direct detection experiments as well as collider limits on additional gauge boson mass and gauge coupling. We also briefly discuss how this model can give rise to sub-eV neutrino masses at tree level as well as one-loop level while keeping the dark matter mass at few tens of GeV. We also constrain the model parameters from the requirement of keeping the one-loop mass difference between two dark matter particles below a keV. We find that the constraints from light neutrino mass and keV mass splitting between two dark matter components show more preference for opposite $CP$ eigenvalues of the two fermion singlet dark matter candidates in the model
description: 27 pages, 6 figures, to appear in Phys. Rev. D
A Hybrid Membership Latent Distance Model for Unsigned and Signed Integer Weighted Networks
Creators: name: Nakis, Nikolaos
name: Çelikkanat, Abdulkadir
name: Mørup, Morten
Publisher: name: arXiv
Year: 2023
Subjects: subject: Social and Information Networks (cs.SI)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Graph representation learning (GRL) has become a prominent tool for furthering the understanding of complex networks providing tools for network embedding, link prediction, and node classification. In this paper, we propose the Hybrid Membership-Latent Distance Model (HM-LDM) by exploring how a Latent Distance Model (LDM) can be constrained to a latent simplex. By controlling the edge lengths of the corners of the simplex, the volume of the latent space can be systematically controlled. Thereby communities are revealed as the space becomes more constrained, with hard memberships being recovered as the simplex volume goes to zero. We further explore a recent likelihood formulation for signed networks utilizing the Skellam distribution to account for signed weighted networks and extend the HM-LDM to the signed Hybrid Membership-Latent Distance Model (sHM-LDM). Importantly, the induced likelihood function explicitly attracts nodes with positive links and deters nodes from having negative interactions. We demonstrate the utility of HM-LDM and sHM-LDM on several real networks. We find that the procedures successfully identify prominent distinct structures, as well as how nodes relate to the extracted aspects providing favorable performances in terms of link prediction when compared to prominent baselines. Furthermore, the learned soft memberships enable easily interpretable network visualizations highlighting distinct patterns.
description: For the published version of the paper please visit Advances in Complex Systems (ACS)
Regenerative Fuel Cell System for Space Exploration Applications
Creators: name:  C. DUPONT
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: SPACE EXPLORATION
ISRU

description: Before 2030 the moon should see a return of humans on its soil. This time the aim will be to stay on our closest satellite and prepare humans for longer missions towards Mars. Thus, the moon will become an exciting playground for testing technologies and assessing permanent human life in space. Many agencies endorsed this ambition and are willing to contribute to this challenging and motivating objective. However, a lot of technological gaps are present and need to be addressed before thinking of a sustainable activity on the moon. This is especially the case for space transportation (reliable lunar landers and rovers), habitat and human health (to provide efficient shelters for preserving human health) or ISRU (capability to use resources present on the moon). A common point of all these different fields is the energy challenge. Indeed, the moon environment is known to be harsh with long periods of darkness and cold (two weeks or permanently). During these lunar nights, the sun cannot provide power anymore and thus energy must be stored. Most common energy storage systems rely on batteries. Even though this technology is highly matured (present in all satellites) it has some limits when the lunar night is too long. This is due to the presently low energy density of batteries (around 150 Wh/Kg). Thus, a higher energy density system must be developed which is the case of RFCS (Regenerative Fuel Cell Systems). The principle is very simple. It consists of splitting the water molecule into H2 and O2 when energy from the sun is available and storing them. Then using the H2 and O2 in a Fuel Cell to produce electrical power when solar energy is no longer available. Unlike batteries, in an RFCS the power output and stored energy are decoupled from each other. Thus, this system can be built having an energy density in a wide range, from 200-300 up to 1000 Wh/kg (low power, very high energy stored), which can reduce the total mass of the energy storage system compared to batteries. Additional mass savings are possible due to potential synergies of RFCS hardware (mainly water electrolyser and gas storage) with other systems required on the Lunar surface such as In-Situ Resource Utilisation and life support systems. This paper will address the recent development made by Air Liquide Advanced Technologies on RFCS technologies and will provide a status on the future demonstrators in progress.
Optimal Ancilla-free Pauli+V Circuits for Axial Rotations
Creators: name: Blass, Andreas
name: Bocharov, Alex
name: Gurevich, Yuri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Recently Neil Ross and Peter Selinger analyzed the problem of approximating z- rotations by means of single-qubit Clifford+T circuits. Their main contribution is a deterministic-search technique which allowed them to make approximating circuits shallower. We adapt the deterministic-search technique to the case of Pauli+V circuits and prove similar results. Because of the relative simplicity of the Pauli+V framework, we use much simpler geometric methods.
description: 27 pages, 3 figures
Asynchronous global-local non-invasive coupling
Creators: name:  A. EL KERIM
name:   P. GOSSELET
name:   F. MAGOULES
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: ADVANCED PERFORMANCE ENGINEERING
MECHANICAL

description: Our aim is to derive an asynchronous version of the local/global non-intrusive coupling. This method can be viewed as an exact version of the submodeling technique which allows using a coarse description of a structure and enriching the modeling of some zones of interest with enhanced geometry, refined mesh, complex material laws. Through iterations, the exact interactions between the local patches and the rest of the structure are computed. The method can also be employed as a simple way to derive a non-overlapping domain decomposition method in the case of patches covering the full domain. Mathematically, the method is a stationary iteration which proved to be particularly robust to solve nonlinear structure mechanics problems (plasticity, crack propagation). One key feature of the method is that it only makes use of standard operations so that it can be implemented as a python script driving reference industrial software like Abaqus, Code Aster. Deriving an asynchronous version would bring several advantages: the method would be more resilient and less sensitive to load balance, it would make better use of the computational resources whether high performance cluster or network of workstations. But it raises several difficulties. Firstly, regarding the algorithm, some simplifications commonly used in the synchronous case are no longer available. Secondly, the convergence analysis is much more complex to set up, and the approaches from the literature need to be adapted. Lastly, from an implementation point of view, several techniques have been tackled in the history, generally based on MPI. The classic approach makes use of non-blocking two-sided communication. More recently one-sided communication was proposed , the idea being that each CPU can directly access the memory of the other CPUs to get or to put pieces of information. In this presentation, we will address all these issues. The performance will be measured thanks to different implementations of the method using a python code driving the getfem finite element software and using the mpi4py library. Thermal and structure mechanics problems in 2D and 3D will be considered. Comparison with a synchronous version of the code will be provided. Different hardware configurations will be used, like the Fusion and Ruche supercomputers commonly used by Ecole CentraleSupelec and ENS Paris Saclay. Among the test cases, a weak scalability study will be performed on an academic configuration, and a turbine blade from the high-pressure compressor of a turbomachine will be studied where patches are used to introduce micro-perforations in the geometry of the leading and trailing edges. Acknowledgement: partial support from French National Research Agency (grant\\# ANR-18-CE46-0008).
Additional file 1 of Elasticity spectra as a tool to investigate actin cortex mechanics
Creators: name: Lüchtefeld, Ines
name: Bartolozzi, Alice
name: Morales, Julián Mejía
name: Dobre, Oana
name: Basso, Michele
name: Zambelli, Tomaso
name: Vassalli, Massimo
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Supplementary materials are provided including comments on the the impact of the rigid substrate on the ES, andthe variation of $$\Lambda$$ Λ .