cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: A locus on chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers
Creators: name: Mausberg, Theresa-Bernadette
name: Wess, Gerhard
name: Simak, Julia
name: Keller, Lisa
name: Drögemüller, Michaela
name: Drögemüller, Cord
name: Webster, Matthew T.
name: Stephenson, Hannah
name: Dukes-McEwan, Joanna
name: Leeb, Tosso
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2011
Subjects: subject: 570

description: Dilated cardiomyopathy (DCM) is a heterogeneous group of heart diseases with a strong genetic background. Currently, many human DCM cases exist where no causative mutation can be identified. DCM also occurs with high prevalence in several large dog breeds. In the Doberman Pinscher a specific DCM form characterized by arrhythmias and/or echocardiographic changes has been intensively studied by veterinary cardiologists. We performed a genome-wide association study in Doberman Pinschers. Using 71 cases and 70 controls collected in Germany we identified a genome-wide significant association to DCM on chromosome 5. We validated the association in an independent cohort collected in the United Kingdom. There is no known DCM candidate gene under the association signal. Therefore, DCM in Doberman Pinschers offers the chance of identifying a novel DCM gene that might also be relevant for human health.
title: On Sharp Identification Regions for Regression Under Interval Data
Creators: name: Schollmeyer, Georg
name: Augustin, Thomas
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2013
Subjects: subject: partial identification, imprecise probabilities, interval data, sharp identification regions, coarse data, adjunctions, partially ordered sets, linear regression model, best linear predictor, set-domained loss function
subject: 510

description: The reliable analysis of interval data (coarsened data) is one of themost promising applications of imprecise probabilities in statistics. If onerefrains from making untestable, and often materially unjustified, strongassumptions on the coarsening process, then the empirical distributionof the data is imprecise, and statistical models are, in Manski’s terms,partially identified. We first elaborate some subtle differences betweentwo natural ways of handling interval data in the dependent variable ofregression models, distinguishing between two different types of identificationregions, called Sharp Marrow Region (SMR) and Sharp CollectionRegion (SCR) here. Focusing on the case of linear regression analysis, wethen derive some fundamental geometrical properties of SMR and SCR,allowing a comparison of the regions and providing some guidelines fortheir canonical construction.Relying on the algebraic framework of adjunctions of two mappings betweenpartially ordered sets, we characterize SMR as a right adjoint andas the monotone kernel of a criterion function based mapping, while SCRis indeed interpretable as the corresponding monotone hull. Finally wesketch some ideas on a compromise between SMR and SCR based on aset-domained loss function.This paper is an extended version of a shorter paper with the same title,that is conditionally accepted for publication in the Proceedings ofthe Eighth International Symposium on Imprecise Probability: Theoriesand Applications. In the present paper we added proofs and the seventhchapter with a small Monte-Carlo-Illustration, that would have made theoriginal paper too long.
Urine Congo red test for the detection of preeclampsia in pregnant women presenting with suspected preeclampsia
Creators: name: Tuntivararut, Phusit
name: Raungrongmorakot, Kasem
name: Chaiyasit, Noppadol
name: Yuenyongdechawat, Nutnaree
name: Chaemsaithong, Piya
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: To determine the predictive performance of the urine Congo red point-of-care test for the identification of preeclampsia in women presenting with suspected preeclampsia. A prospective multi-center cohort study was conducted to include women with suspected preeclampsia (n = 244). The urine Congo red test was determined (score range 1–8). The diagnosis of preeclampsia was based on criteria proposed by The American College of Obstetricians and Gynecologists. The primary outcome was the predictive performance (sensitivity, specificity, negative and positive predictive values, as well as likelihood ratios) of the Congo red kit test for the diagnosis of preeclampsia. Fifty-four percent (131/244) of women with suspected preeclampsia subsequently developed preeclampsia. The sensitivity and specificity of the urine Congo red test were 49.6% and 94.7%, respectively, when using a cutoff for Congo red ≥4. The test had a significant positive correlation with the level of urine protein (Pearson correlation 0.61, p-value <.01). Intra- and inter-observer reliabilities were good (intra-class correlation coefficient and Cohen’s kappa coefficient of 0.88 and 0.75, respectively; p < .01). The urine Congo red kit test has a high positive predictive performance for the identification of preeclampsia with high reproducibility. This test may be used as a bed side test to rule-in the diagnosis of preeclampsia in women presenting with suspected preeclampsia.
title: Diffusion of myosin V on microtubules
title: A fine-tuned interaction for which E-hooks are dispensable
titleType: Subtitle
Creators: name: Zimmermann, Dennis
name: Abdel Motaal, Basma
name: Voith von Voithenberg, Lena
name: Schliwa, Manfred
name: Ökten, Zeynep
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2011
Subjects: subject: 570

description: Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered. Recently, in vitro studies revealed that the actin-based processive motor myosin V also binds to, and diffuses along microtubules. This biophysical trick enables cells to exploit both tracks for the same transport process without switching motors. The detailed mechanisms underlying this behavior remain to be solved. By means of single molecule Total Internal Reflection Microscopy (TIRFM), we show here that electrostatic tethering between the positively charged loop 2 and the negatively charged C-terminal E-hooks of microtubules is dispensable. Furthermore, our data indicate that in addition to charge-charge interactions, other interaction forces such as non-ionic attraction might account for myosin V diffusion. These findings provide evidence for a novel way of myosin tethering to microtubules that does not interfere with other E-hook-dependent processes.
title: Functional characterization of cultured keratinocytes after acute cutaneous burn injury.
Creators: name: Gauglitz, Gerd
name: Zedler, Siegfried
name: Spiegel, Felix von
name: Fuhr, Jasmin
name: Henkel von Donnersmarck, Guido
name: Faist, Eugen
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012
Subjects: subject: 610

description: In addition to forming the epithelial barrier against the outside environment keratinocytes are immunologically active cells. In the treatment of severely burned skin, cryoconserved keratinocyte allografts gain in importance. It has been proposed that these allografts accelerate wound healing also due to the expression of a favourable--keratinocyte-derived--cytokine and growth factor milieu.In this study the morphology and cytokine expression profile of keratinocytes from skin after acute burn injury was compared to non-burned skin. Skin samples were obtained from patients after severe burn injury and healthy controls. Cells were cultured and secretion of selected inflammatory mediators was quantified using Bioplex Immunoassays. Immunohistochemistry was performed to analyse further functional and morphologic parameters.Histology revealed increased terminal differentiation of keratinocytes (CK10, CK11) in allografts from non-burned skin compared to a higher portion of proliferative cells (CK5, vimentin) in acute burn injury. Increased levels of IL-1Î±, IL-2, IL-4, IL-10, IFN-Î³ and TNFÎ± could be detected in culture media of burn injury skin cultures. Both culture groups contained large amounts of IL-1RA. IL-6 and GM-CSF were increased during the first 15 days of culture of burned skin compared to control skin. Levels of VEGF, FGF-basic, TGF-ß und G-CSF were high in both but not significantly different. Cryoconservation led to a diminished mediator synthesis except for higher levels of intracellular IL-1Î± and IL-1ß.Skin allografts from non-burned skin show a different secretion pattern of keratinocyte-derived cytokines and inflammatory mediators compared to keratinocytes after burn injury. As these secreted molecules exert auto- and paracrine effects and subsequently contribute to healing and barrier restoration after acute burn injury therapies affecting this specific cytokine/growth factor micromilieu could be beneficial in burned patients.
title: DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression.
Creators: name: Zill, Peter
name: Baghai, Thomas C.
name: Schüle, Cornelius
name: Born, Christoph
name: Früstück, Clemens
name: Büttner, Andreas
name: Eisenmenger, Wolfgang
name: Varallo-Bedarida, Gabriella
name: Rupprecht, Rainer
name: Möller, Hans-Jürgen
name: Bondy, Brigitta
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012
Subjects: subject: 610

description: The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD). In this context, functional polymorphisms of the ACE gene have been linked to depression, to antidepressant treatment response, to ACE serum concentrations, as well as to hypertension, myocardial infarction and CVD risk markers. The mostly investigated ACE Ins/Del polymorphism accounts for ~40%-50% of the ACE serum concentration variance, the remaining half is probably determined by other genetic, environmental or epigenetic factors, but these are poorly understood.The main aim of the present study was the analysis of the DNA methylation pattern in the regulatory region of the ACE gene in peripheral leukocytes of 81 MD patients and 81 healthy controls.We detected intensive DNA methylation within a recently described, functional important region of the ACE gene promoter including hypermethylation in depressed patients (p = 0.008) and a significant inverse correlation between the ACE serum concentration and ACE promoter methylation frequency in the total sample (p = 0.02). Furthermore, a significant inverse correlation between the concentrations of the inflammatory CVD risk markers ICAM-1, E-selectin and P-selectin and the degree of ACE promoter methylation in MD patients could be demonstrated (p = 0.01 - 0.04).The results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders.
title: Die Suche nach einer "anderen Realität"
Creators: name: Friesenbichler, Katrin Maria
Year: 2013

description: Die vorliegende Masterarbeit beschäftigt sich mit der Frage, wie sich in den Gemälden von František Kupka die gleichzeitige Beeinflussung des Künstlers einerseits durch die Wissenschaft mit ihren rationalen Argumenten und andererseits durch esoterische, mystische und okkulte Strömungen widerspiegelt und in welcher Weise sich in den Bildern zeigt, wie sich der Maler mit diesen widersprüchlichen Denkmodellen auseinandergesetzt hat. Kupkas Gemälde stehen exemplarisch für jenen Zwiespalt, in dem sich viele KünstlerInnen zu Beginn des 20. Jahrhunderts befanden und der als Folge des Modernisierungsprozesses zu verstehen ist. Um dieses Spannungsfeld näher zu beleuchten, habe ich zwei Gemälde František Kupkas mithilfe der Segmentanalyse nach Roswitha Breckner interpretiert: Amorpha, fugue à deux couleurs (1912) und L’Eau, la baigneuse (1906–1909).
description: This thesis deals with the question, how the simultaneous influence of science with its rational arguments on the one hand, and of esoteric-mystical and occult tendencies on the other hand is reflected in František Kupka’s paintings and in what way the artist deals with these contradictory cognitive models in his work of art. Kupka’s paintings stand exemplarily for that conflict in which many artists have found themselves at the beginning of the 20th century as a result of the process of modernisation. In order to illuminate these areas of conflict, I have interpreted two paintings of František Kupka with the help of the segment analysis of Roswitha Breckner: Amorpha, fugue à deux couleurs (1912) und L’Eau, la baigneuse (1906–1909).
title: Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and Î³-secretase.
Creators: name: Hogl, Sebastian
name: Kuhn, Peer-Hendrik
name: Colombo, Alessio
name: Lichtenthaler, Stefan F.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2011
Subjects: subject: 610

description: Regulated intramembrane proteolysis of the amyloid precursor protein (APP) by the protease activities Î±-, Î²- and Î³-secretase controls the generation of the neurotoxic amyloid Î² peptide. APLP2, the amyloid precursor-like protein 2, is a homolog of APP, which shows functional overlap with APP, but lacks an amyloid Î² domain. Compared to APP, less is known about the proteolytic processing of APLP2, in particular in neurons, and the cleavage sites have not yet been determined. APLP2 is cleaved by the Î²-secretase BACE1 and additionally by an Î±-secretase activity. The two metalloproteases ADAM10 and ADAM17 have been suggested as candidate APLP2 Î±-secretases in cell lines. Here, we used RNA interference and found that ADAM10, but not ADAM17, is required for the constitutive Î±-secretase cleavage of APLP2 in HEK293 and SH-SY5Y cells. Likewise, in primary murine neurons knock-down of ADAM10 suppressed APLP2 Î±-secretase cleavage. Using mass spectrometry we determined the proteolytic cleavage sites in the APLP2 sequence. ADAM10 was found to cleave APLP2 after arginine 670, whereas BACE1 cleaves after leucine 659. Both cleavage sites are located in close proximity to the membrane. Î³-secretase cleavage was found to occur at different peptide bonds between alanine 694 and valine 700, which is close to the N-terminus of the predicted APLP2 transmembrane domain. Determination of the APLP2 cleavage sites enables functional studies of the different APLP2 ectodomain fragments and the production of cleavage-site specific antibodies for APLP2, which may be used for biomarker development.
title: Das Rechtshilfesystem in der VR China mit Schwerpunkt auf "Rechtskliniken" an Universitäten
Creators: name: Pasteka, Anna Theresia
Year: 2013

description: Die vorliegende Arbeit untersucht die universitären Rechtskliniken (legal clinics) der VR China und ihr Programm, die eine neue Form der Rechtshilfe und des Rechtsunterrichts in China darstellen. Im Rahmen einer Kritischen Diskursanalyse nach Siegfried Jäger wird der Schwerpunkt auf den institutionellen Rahmen, also auf den „Kontext“, und auf die inhaltlich-ideologischen Aussagen und Themenfelder bezüglich der Rechtskliniken gelegt.
Faulen und Rosstock : von Wyticon nach starkem Schneefall
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1867

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Sonnenfleckenzeichnung Nr. 1261.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.10.1892, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1892

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
title: Der Wein in Kana im Licht biblischer und frühjüdischer Texte
Creators: name: Böhm, Kerstin
Year: 2013

description: Die vorliegende Arbeit geht der Bedeutung des Weins in den biblischen und ausgewählten frühjüdischen Schriften (Qumranschriften, TestXII) nach, um anschließend die Erzählung vom Weinwunder zu Kana in Joh 2,1-11 aus den verschiedenen Perspektiven der erhobenen Bedeutungen des Weins zu beleuchten. Die Untersuchung der Texte zeigt die wichtige Stellung, aber auch die Ambivalenz des Weins. Der Großteil der Textstellen lässt sich dabei in vier große Kategorien einteilen: Wein als Grundnahrungsmittel, Thematisierung der Auswirkungen des Weinkonsums, Wein in Bildern des Heils und Wein in Bildern des Gerichts. Im Hinblick auf die Erzählung Joh 2,1-11 zeigt die Perspektive des Weins als Grundnahrungsmittel besonders, dass der Weinmangel eine genuine Not darstellt. Durch ihre Abwendung erscheint Jesus zunächst als Wundertäter. Auch eine Bezugnahme auf und Überbietung des Mose scheint plausibel. Die Perspektive der Auswirkungen des Weinkonsums beleuchtet die geschätzte euphorisierende, Genuss stiftende und Gemeinschaft fördernde Wirkung des Weins. Die vielfältigen Weinmotive in Bildern eschatologischen Heils lassen das Zeichen in Joh 2 als Zeichen dafür verstehen, dass das Eschaton mit dem Auftreten Jesu angebrochen ist. Jesus ist der Heilsbringer. Der Hinweis auf die nicht gekommenen Stunde zeigt, dass sich Inhalt und Umfang des von Jesus gebrachten Heils nur von seiner Erhöhung und Verherrlichung her verstehen lassen, obwohl das Neue mit Jesus bereits angebrochen ist. Die Gerichtsbilder führen vor, dass den Kelch aus der Hand des Kyrios die einen zum Heil, die anderen zum Gericht trinken können. Angesichts des Dualismus des Joh erscheint auch diese Lesung für das Evangelium stimmig: An Jesus entscheidet sich das Heil der Hochzeitsgesellschaft. Das Zeichen zeigt seine Herrlichkeit, die es zu sehen und zu glauben gilt. An der Reaktion der Hochzeitsgäste könnte sich entscheiden, was der reichliche Wein für sie bedeutet. Diese Vielfalt der Anknüpfungspunkte scheint vom Evangelisten gerade intendiert, wenn er den Wein als Gegenstand des ersten Zeichens Jesu in seinem Evangelium wählt. Zudem zeigen die Qualifizierungen des Vorgang als Zeichen und Offenbarung der Herrlichkeit Jesu sehr deutlich, dass es hier um mehr geht als die wunderbare Gabe selbst.
title: Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates.
Creators: name: Latzin, Philipp
name: Frey, Urs
name: Armann, Jakob P.
name: Kieninger, Elisabeth
name: Fuchs, Oliver
name: Röösli, Martin
name: Schaub, Bianca
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2011
Subjects: subject: 610

description: Ambient air pollution can alter cytokine concentrations as shown in vitro and following short-term exposure to high air pollution levels in vivo. Exposure to pollution during late pregnancy has been shown to affect fetal lymphocytic immunophenotypes. However, effects of prenatal exposure to moderate levels of air pollutants on cytokine regulation in cord blood of healthy infants are unknown.In a birth cohort of 265 healthy term-born neonates, we assessed maternal exposure to particles with an aerodynamic diameter of 10 Âµm or less (PMââ), as well as to indoor air pollution during the last trimester, specifically the last 21, 14, 7, 3 and 1 days of pregnancy. As a proxy for traffic-related air pollution, we determined the distance of mothers' homes to major roads. We measured cytokine and chemokine levels (MCP-1, IL-6, IL-10, IL-1ß, TNF-Î± and GM-CSF) in cord blood serum using LUMINEX technology. Their association with pollution levels was assessed using regression analysis, adjusted for possible confounders.Mean (95%-CI) PMââ exposure for the last 7 days of pregnancy was 18.3 (10.3-38.4 Âµg/mÂ³). PMââ exposure during the last 3 days of pregnancy was significantly associated with reduced IL-10 and during the last 3 months of pregnancy with increased IL-1ß levels in cord blood after adjustment for relevant confounders. Maternal smoking was associated with reduced IL-6 levels. For the other cytokines no association was found.Our results suggest that even naturally occurring prenatal exposure to moderate amounts of indoor and outdoor air pollution may lead to changes in cord blood cytokine levels in a population based cohort.
Hüffi oder Düssjstock Griesstock : von Höchenschwand
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1864

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: Stationarity and second order behaviour of discrete and continuous time GARCH(1,1) processes
Creators: name: Klüppelberg, Claudia
name: Lindner, Alexander M.
name: Maller, R. A.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2003
Subjects: subject: 510

description: We use a discrete time analysis, giving necessary and sufficient conditions for the almost sure convergence of ARCH(1) and GARCH(1,1) discrete time models, to suggest an extension of the (G)ARCH concept to continuous time processes. The models, based on a single background driving Levy process, are different from, though related to, other continuous time stochastic volatility models that have been proposed. Our models generalise the essential features of discrete time GARCH processes, and are amenable to further analysis, possessing useful Markovian and stationarity properties.
Kröntlet : vom Bachtel durch Fernrohr
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1865

description: Der Krönten, auf der Siegfriedkarte als Krönlet bezeichnet
description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: Parsimonious Segmentation of Time Series' by Potts Models
Creators: name: Winkler, Gerhard
name: Kempe, A.
name: Liebscher, V.
name: Wittich, O.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2003
Subjects: subject: 510

description: Typical problems in the analysis of data sets like time-series or images crucially rely on the extraction of primitive features based on segmentation. Variational approaches are a popular and convenient framework in which such problems can be studied. We focus on Potts models as simple nontrivial instances. The discussion proceeds along two data sets from brain mapping and functional genomics.
Kröntlet : vom Kapf bey Zumikon
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1864

description: Der Krönten, auf der Siegfriedkarte als Krönlet bezeichnet
description: J. M.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: A Study of the Austrian Labour Makret Dynamics Using a Model of Search Equilibrium
Creators: name: Launov, A.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2003
Subjects: subject: 510

description: In this work we provide a theoretical overview of a search equilibrium model with continuous productivity dispersion and perform its estimation for the Austrian data. We describe empirically the dynamics of market equilibrium outcomes. Special emphasis is made on the analysis of changes in labour mobility and dependence of expected job durations on offered wages. We investigate the influence of excessive labour mobility on the equilibrium profits of firms. Facing a problem of top-coded wage data, we suggest an appropriate adjustment of the existing estimation methodology. Finally, we extend the econometric model for the observed heterogeneity of agents.
Sonnenfleckenzeichnung Nr. 56.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.03.1961, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1961

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
title: Managementmaßnahmen begleitendes Monitoring
Creators: name: Brunner, Evelyn
Year: 2013

description: Managementmaßnahmen sind ein wichtiger Bestandteil im Naturschutz. Um deren Erfolg zu kontrollieren, wurden im Naturpark Fanes-Sennes-Prags 22 Monitoringflächen angelegt. Die Dauerflächen wurden mehrfach verortet. Die Standorte befinden sich auf Moor- und Wiesenlebensräumen, die entweder einem Nutzungswandel bzw. einem Management unterliegen oder eine Referenzfläche dazu darstellen. Durch mehrere Erhebungsmethoden der Vegetationsökologie wird der Ist-Zustand verschiedener Vegetationsparameter für die einzelnen Flächen ermittelt und hinsichtlich ihrer Bewirtschaftungsform verglichen (Mahd, Beweidung und Nutzungsaufgabe). Um die Flächen qualitativ zu erfassen, werden die einzelnen Standorte einer pflanzensoziologischen Analyse unterworfen. Die Pflanzengesellschaften werden dabei sowohl auf der gesamten Monitoringfläche (5x5 m), als auch für die einzelnen Frequenzplots (1x1 m) ermittelt. Bei einem Vergleich der beiden Erhebungsmethoden wird festgehalten, dass die Größe der Untersuchungsflächen den Unterschied in den Ergebnissen bedingt. Der Vergleich der Flächen in Hinblick auf die Deckungswerte verschiedener (Bewirtschaftungs-) Merkmale entspricht großteils den Erwartungen. Folglich sind tote Biomasse auf brachliegenden Flächen und Stickstoff-liebende Arten sowie offener Boden auf Weiden vermehrt anzutreffen. Dies spiegelt sich jeweils bei den Ergebnissen für Wiesenlebensräume klarer wider als bei den Mooren. Bei der Gegenüberstellung von Mooren und Wiesen zeigen sich in den Ergebnissen auch große Abweichungen hinsichtlich ihrer Vertikalstruktur. Die Annahme der größeren Standardabweichung der Mittelwerte aller vier Probepunkte je Fläche kann nur auf beweideten Wiesenflächen bestätigt werden. Dabei spielt das selektive Fressverhalten der Weidetiere eine Rolle. Das Langzeitmonitoring kann Veränderungen und Sukzessionsabläufe bei unterschiedlichen Nutzungsbedingungen aufzeigen und bei der Erstellung eines Weide- und Bewirtschaftungskonzepts herangezogen werden. Die Daten sowie die Bilder der Monitoringflächen liegen der Arbeit als CD bei.
title: Analysing the course of multiple sclerosis with segmented regression models
Creators: name: Hellriegel, B.
name: Daumer, Martin
name: Neiß, A.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2003
Subjects: subject: 510

description: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system whose cause is still unknown. The disease course shows great inter- and intra-individual variability and this results in insecurity of diagnosis and prognosis. A well-founded knowledge of the natural history of MS, however, is an important prerequisite for developing adequate strategies for therapy and research.  In order to increase our understanding we developed a segmented regression model which extracts three main characteristics of the time course of this complex disease from natural history data. For each individual patient this model determines baseline disability (as measured by the Expanded Disability Status Scale = EDSS), the time point where the disease starts to progress and the slope of this progression. The model is applied to data of patient registries from all over the world that are pooled in the database of the Sylvia Lawry Centre for Multiple Sclerosis Research (SLCMSR). The analyses used a random subsample of the entire database and were restricted to patients seen from onset of MS with time series of at least three years. Thereby we were able to avoid some of the problems related to missing data. Our results revealed a weak negative correlation between time to progression (change point) and slope of progression for this group of patients, i.e. those patients who do progressed later and remained stable for a longer time developed disability more slowly than those who progressed earlier. For the two parameters and their interaction we did not find an influence of basic covariates like gender, disease course and mono- or poly-symptomatic disease onset. According to the SLCMSR Policy these results will be subjected to a validation using an independent "validation dataset". This remains to be done.
Co-existing chronic hypertension and hypertensive disorders of pregnancy and associated adverse pregnancy outcomes
Creators: name: Sweeney, Lena C.
name: Lundsberg, Lisbet S.
name: Culhane, Jennifer F.
name: Partridge, Caitlin
name: Son, Moeun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Chronic hypertension (CHTN) causes vascular damage and resistance in the pregnant person and malperfusion in the placenta which may worsen the endothelial dysfunction of hypertensive disorders of pregnancy (HDP). These conditions frequently co-exist. A cumulative effect has been inconsistently demonstrated in prior studies, and it is unclear how co-existing hypertensive conditions affect pregnancy outcomes. We sought to examine maternal and neonatal outcomes in pregnancies affected by co-existing CHTN and HDP and compare these outcomes to those of pregnancies which were unaffected or affected by either condition alone. This is a retrospective cohort study of singleton deliveries at a single institution 1 October 2013 to 1 October 2021. Data were extracted from the electronic medical record using standardized definitions and billing and diagnosis codes. Pregnant people with no evidence of hypertensive condition were compared to those with CHTN only, HDP only, and co-existing CHTN and HDP. Demographics, baseline clinical data, and use of aspirin or antihypertensive medications were assessed. Maternal outcomes included cesarean delivery, critical range blood pressure, intensive care unit (ICU) admission, and death. Neonatal outcomes included preterm birth <37 weeks’ gestation, small for gestational age (SGA) birthweight, ICU admission, and a morbidity composite. Bivariate tests of association were performed using Chi-square test. Crude and adjusted odds ratios (aORs) were calculated using logistic regression for three maternal and four neonatal outcomes. Descriptive statistics and multivariable analyses were performed. Of 40,840 eligible people, 1451 (3.6%) had CHTN only; 5213 (12.8%) had HDP only; and 1890 (4.6%) had co-existing CHTN and HDP. Though odds of adverse maternal and neonatal outcomes were significantly increased for all hypertensive groups relative to the unaffected referent group, co-existing CHTN and HDP had the highest odds of cesarean delivery (aOR 1.60; 95% confidence interval (CI) 1.45–1.77), critical blood pressure (OR 41.54; 95% CI 35.96–47.99), maternal ICU admission or death (aOR 3.52; 95% CI 2.65–4.67), preterm birth (aOR 2.76; 95% CI 2.41–3.16), and SGA birthweight (aOR 1.61; 95% CI 1.39–1.87). Hypertensive disorders of pregnancy in the setting of CHTN are associated with the highest odds of serious consequences on the pregnant person and neonate independent of maternal comorbidities and prematurity. Antihypertensive medication use lowers the odds of some adverse outcomes. Patients should be informed of heightened risks, but optimal management remains unclear.
title: Diffusion Tensor Imaging: on the assessment of data quality - a preliminary bootstrap analysis
Creators: name: Heim, Susanne
name: Hahn, Klaus
name: Auer, Dorothee P.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2003
Subjects: subject: 510

description: In the field of nuclear magnetic resonance imaging, diffusion tensor imaging (DTI) has proven an important method for the characterisation of ultrastructural tissue properties. Yet various technical and biological sources of signal uncertainty may prolong into variables derived from diffusion weighted images and thus compromise data validity and reliability. To gain an objective quality rating of real raw data we aimed at implementing the previously described bootstrap methodology (Efron, 1979) and investigating its sensitivity to a selection of extraneous influencing factors. We applied the bootstrap method on real DTI data volumes of six volunteers which were varied by different acquisition conditions, smoothing and artificial noising. In addition a clinical sample group of 46 Multiple Sclerosis patients and 24 healthy controls were investigated. The response variables (RV) extracted from the histogram of the confidence intervals of fractional anisotropy were mean width, peak position and height. The addition of noising showed a significant effect when exceeding about 130% of the original background noise. The application of an edge-preserving smoothing algorithm resulted in an inverse alteration of the RV. Subject motion was also clearly depicted whereas its prevention by use of a vacuum device only resulted in a marginal improvement. We also observed a marked gender-specific effect in a sample of 24 healthy control subjects the causes of which remained unclear. In contrary to this the mere effect of a different signal intensity distribution due to illness (MS) did not alter the response variables.
title: Encapsulation of polyaniline in zeolite Y and mordenite
Creators: name: Bein, Thomas
name: Enzel, Patricia
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 1989
Subjects: subject: 540

description: Synthetic strategies to encapsulate polyaniline in the crystalline channel system offaujasite (three-dimensional) and mordenite (one-dimensional) have been explored. Theadsorption of anilinium precursor into the zeolite host and its successful oxidation topolyaniline have been studied utilizing FTIR, Fourier Transform Raman, and electronicspectroscopies. The dimensionality of the host channel system and the concentration
Sonnenfleckenzeichnung Nr. 1249.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.09.1892, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1892

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
title: Oxometalate-glass composites and thin films
Creators: name: Möller, Karin
name: Bein, Thomas
name: Brinker, C. J.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 1990
Subjects: subject: 540

description: New glass-composites with ion exchange properties have been developed.Ammonium 12-molybdophosphate (AMP) (ÎÎ4)3Î¡ÎÎ¿Î2Î¸4Î¿, and ammonium 12-tungstophosphate (AWP) (Nh4)3PW12O40, known for their ion exchangecapabilities, are included either in preformed aerogels with defined pore size, or areadded to sol-gel mixtures during the process of gel formation. Characterization iscarried out by FTIR, Raman and EXAFS spectroscopy. Ion exchange capacities for theoxometalate precursors are determined for silver and rubidium and are compared tothose of the glass composites. Glass composites show high ion exchange capacity, butsome portion of the metalate complexes leaches from the glass during the procedure.This is in contrast to thin composite films, which have almost no porosity and do notshow loss of metalate. EXAFS spectroscopy demostrates that the oxometalatemicrostructure is maintained in glass composites and that rubidium ions after ionexchange in glasses occupy similar cation positions as in the precursor compounds.
title: Doping and band-gap engineering of an intrazeolite tungsten(VI) oxide supralattice
Creators: name: Ozin, Geoffrey A.
name: Malek, Andrzij
name: Prokopowicz, Richard
name: Macdonald, Peter M.
name: Oezkar, Saim
name: Möller, Karin
name: Bein, Thomas
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 1991
Subjects: subject: 540

description: New results are presented concerning the topotactic self-assembly, n-typedoping and band-gap engineering of an intrazeolite tungsten(VI) oxide supralatticen(W03)-Na56Y, where 0 < η < 32, built-up of single size and shape (W03)2dimers. In particular it has been found that the oxygen content of these dimerscan be quantitatively adjusted by means of a thermal vacuum induced reversiblereductive-elimination oxidative-addition of dioxygen. This provides access to newn(W03.x)-Na56Y materials (0 < Ï ^ 1.0) in which the oxygen content, structuralproperties and electronic architecture of the dimers are changed. In this way onecan precisely control the oxidation state, degree of η-doping and band-filling of atungsten(VI) oxide supralattice through an approach which can be considered akinto, but distinct in detail to, that found in the Magneli crystallographic shear phasesof non-stoichiometric bulk W03.x . Another discovery concerns the ability to alterlocal electrostatic fields experienced by the tungsten(VI) oxide moieties housed inthe 13Ä supercages of 16(W03)-M36Y, by varying the ionic potential of theconstituent supercage M + cations across the alkali metal series. This methodprovides the first opportunity to fine-tune the band-gap of a tungsten(VI) oxidesupralattice. Î miniband electronic description is advanced as a qualitative firstattempt to understand the origin of the above effects. The implications of thesediscoveries are that cluster size, composition and intrinsic electrostatic field effectscan be used to "chemically manipulate" (engineer) the doping and bandarchitecture of intrazeolite supralattices of possible interest in quantum electronicsand nonlinear optics.
Schächenthaler Windgelle : in vereinzelter Erleuchtung die hintern höheren Berge in Schneegewölk
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1863

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Gebirgsansicht vom Speer durch Fernrohr (bey trüber Luft)
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1867
Subjects: Gletscher

description: IM.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Sonnenfleckenzeichnung Nr. 1244.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.09.1892, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1892

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
Hüfistock : vom Mühlebach gez durch Fernrohr ; Gros Ruchen Ct. Uri : vom Zürichberg ob Carolinaburg
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1867

description: [Johann Müller-Wegmann]
description: Die Zeichnung "Hüfistock" wird im Katalog der Müller-Wegmann'schen Sammlung mit Düssistock bezeichnet
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Blackenstock Urirothstock Schlossberg Spanort : von Wengibad durch Fernrohr
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1869
Subjects: Kanton Uri

description: IM.
description: Unten links Hinweis: "NB zwischen Schlossstock [mit Bleistift darüber als Schlossberg bezeichnet] und Blumlisalpgletscher liegt der Surenenpass"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Prenatal exposure to intra-amniotic infection with Ureaplasma species increases the prevalence of bronchopulmonary dysplasia
Creators: name: Yamamoto, Tomoko
name: Nomiyama, Makoto
name: Oshima, Yuko
name: Ono, Takeshi
name: Kozuma, Yutaka
name: Nakura, Yukiko
name: Yanagihara, Itaru
name: Tsumura, Keisuke
name: Yokoyama, Masatoshi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: The present study investigated the relationship between bronchopulmonary dysplasia (BPD) and intra-amniotic infection with Ureaplasma species. This was a single-center, retrospective cohort study. Patients with singleton pregnancies who underwent inpatient management at our department for preterm premature rupture of membranes (PPROM), preterm labor, cervical insufficiency, and asymptomatic cervical shortening at 22–33 gestational weeks were included. Amniocentesis was indicated for patients with PPROM or an elevated maternal C-reactive protein level (≥0.58 mg/dL). Patients with an amniotic fluid IL-6 concentration ≥3.0 ng/mL were diagnosed with intra-amniotic inflammation, while those with positive aerobic, anaerobic, M. hominis, and Ureaplasma spp. cultures were diagnosed with microbial invasion of the amniotic cavity (MIAC). Patients who tested positive for both intra-amniotic inflammation and MIAC were considered to have intra-amniotic infection. An umbilical vein blood IL-6 concentration >11.0 pg/mL indicated fetal inflammatory response syndrome (FIRS). The maternal inflammatory response (MIR) and fetal inflammatory response (FIR) were staged using the Amsterdam Placental Workshop Group Consensus Statement. Intra-amniotic infection with Ureaplasma spp. was diagnosed in 37 patients, intra-amniotic infection without Ureaplasma spp. in 28, intra-amniotic inflammation without MIAC in 58, and preterm birth without MIR/FIR and FIRS in 86 as controls. Following an adjustment for gestational age at birth, the risk of BPD was increased in patients with intra-amniotic infection with Ureaplasma spp. (adjusted odds ratio: 10.5; 95% confidence interval: 1.55–71.2), but not in those with intra-amniotic infection without Ureaplasma spp. or intra-amniotic inflammation without MIAC. BPD was only associated with intra-amniotic infection with Ureaplasma species.
title: "The I Inside"
Creators: name: Schwarz, Ines
Year: 2013

description: Die vorliegende Arbeit widmet sich der Analyse des Films „The I Inside“ unter den Aspekten der unbewussten Wahrnehmung und dem Zeiterleben des Menschen. Die Verquickung dieser beiden Thematiken wird analysiert und herausgearbeitet. Der Film handelt von einem Autounfall, nach welchem der Protagonist ins Krankenhaus eingeliefert wird und im Laufe des Films Zeitsprünge vollzieht, die nicht in eine chronologische Reihung mit dem zuvor stattgefundenen Autounfall gebracht werden können. Die Arbeit erforscht, wie der Regisseur das Unterbewusstsein des Protagonisten filmisch darzustellen versucht. Dies wird durch Screenshots der besprochenen Szenen unterstützt. Da der Film sich auf drei Zeitebenen abspielt, muss herausgefunden werden, welche nun „real“ im Leben des Protagonisten stattfinden. Deshalb befindet sich der Protagonist auch während des Films auf der Suche nach seiner Erinnerung. Diese Suche wird unter anderem durch Stiegen, Puzzle, Jumpcuts und ungewöhnliche Einstellungen dargestellt. Auch die Nebenfiguren werden zu Hinweisen für die Zeitsprünge.
title: Untersuchung der Modulation GABA-induzierter Ströme durch ausgewählte beta 2/3 selektive Liganden
Creators: name: Kaya, Sibel
Year: 2013

description: Hintergrund: γ-aminobuttersäure (GABA) ist der wichtigste, inhibitorische Neurotransmitter im Gehirn der Säugetiere. Sie reguliert durch Interaktion mit ionotropen GABA Typ A (GABAA-) Rezeptoren eine Vielzahl physiologischer Vorgänge einschließlich der neuronalen Erregbarkeit. Daher werden GABAA-Rezeptoren auch von zahlreichen Arzneistoffen wie den Benzodiazepinen, Anästhetika oder Antikonvulsiva moduliert. Zielsetzung: Die meisten der klinisch verwendeten Arzneistoffe weisen neben den erwünschten Wirkungen auch zahlreiche Nebenwirkungen auf, die zum Teil auf eine zu geringe Selektivität zurückzuführen sein können. So modulieren z.B. die Benzodiazepine den am häufigsten vorkommenden GABAA-Rezeptor, der aus α-, β- und γ2 Untereinheiten besteht. Daher versucht man Substanzen zu entwickeln, die noch selektiver mit bestimmten GABAA-Rezeptor Subtypen interagieren, um somit ggf. das Nebenwirkungsprofil zu reduzieren. Im Rahmen der Diplomarbeit wurde eine Reihe von Naturstoffderivaten bezüglich ihrer selektiven Interaktion mit GABAA-Rezeptoren untersucht. Methode: Dafür wurden rekombinante GABAA-Rezeptoren (α1β3γ2S) in Xenopus laevis Oozyten exprimiert und die konzentrationsabhängige Potenzierung von IGABA durch 6 Naturstoffderivate mittels der 2-Mikroelektrodenspannungsklemmtechnik und eines schnellen Perfusionssystems untersucht. Ergebnisse und Interpretation: 2 der untersuchten Naturstoffderivate (SB33 und SB29) führten zu einer stärker ausgeprägten Potenzierung von IGABA im Vergleich zu VA (max. IGABA PotenzierungVA = 567±170% vs. max. IGABA PotenzierungSB33 = 1086±191% vs. max. IGABA PotenzierungSB29 = 670±23%). Die anderen Derivate induzierten entweder vergleichbare oder schwächere IGABA Modulation als VA. Keines der Derivate wies eine signifikant niedrigere EC50 als VA auf. Derivat SB34 zeigte keinen Effekt. Diese Daten stellen einen wesentlichen Beitrag zur Erstellung einer Struktur-Wirkungsbeziehung von VA und ihren Derivaten dar.