cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dark matter profiles and annihilation in dwarf spheroidal galaxies: prospectives for present and future gamma-ray observatories - I. The classical dSphs
Creators: name: Charbonnier, A.
name: Combet, C.
name: Daniel, M.
name: Funk, S.
name: Hinton, J. A.
name: Maurin, D.
name: Power, C.
name: Read, J. I.
name: Sarkar, S.
name: Walker, M. G.
name: Wilkinson, M. I.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Due to their large dynamical mass-to-light ratios, dwarf spheroidal galaxies (dSphs) are promising targets for the indirect detection of dark matter (DM) in gamma-rays. We examine their detectability by present and future gamma-ray observatories. The key innovative features of our analysis are: (i) We take into account the angular size of the dSphs; while nearby objects have higher gamma ray flux, their larger angular extent can make them less attractive targets for background-dominated instruments. (ii) We derive DM profiles and the astrophysical J-factor (which parameterises the expected gamma-ray flux, independently of the choice of DM particle model) for the classical dSphs directly from photometric and kinematic data. We assume very little about the DM profile, modelling this as a smooth split-power law distribution, with and without sub-clumps. (iii) We use a Markov Chain Monte Carlo (MCMC) technique to marginalise over unknown parameters and determine the sensitivity of our derived J-factors to both model and measurement uncertainties. (iv) We use simulated DM profiles to demonstrate that our J-factor determinations recover the correct solution within our quoted uncertainties. Our key findings are: (i) Sub-clumps in the dSphs do not usefully boost the signal; (ii) The sensitivity of atmospheric Cherenkov telescopes to dSphs within 20 kpc with cored halos can be up to ~50 times worse than when estimated assuming them to be point-like. Even for the satellite-borne Fermi-LAT the sensitivity is significantly degraded on the relevant angular scales for long exposures, hence it is vital to consider the angular extent of the dSphs when selecting targets; (iii) No DM profile has been ruled out by current data, but using a prior on the inner dark matter cusp slope 0<=gamma<=1 provides J-factor estimates accurate to a factor of a few if an appropriate angular scale [abridged]
description: 31 pages, 49 figures (2 new figures, section 5.1.5 extended, new App. H2, clarifications), accepted for publication in MNRAS
Additional file 1 of Assessment of self-medication practices in the context of the COVID-19 outbreak in Togo
Creators: name: Sadio, Arnold J.
name: Fifonsi A. Gbeasor-Komlanvi
name: Konu, Rodion Y.
name: Bakoubayi, Akila W.
name: Tchankoni, Martin K.
name: Bitty-Anderson, Alexandra M.
name: Gomez, Iris M.
name: Denadou, Claudia P.
name: Anani, Joël
name: Kouanfack, Harold R.
name: Kpeto, Innocent K.
name: Mounerou Salou
name: Ekouevi, Didier K.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Surveillance Survey of SARS-CoV-2 Infection in Populations at Risk of Lomé-Commune in 2020: Survey sheet. This is a questionnaire developed for data collection for this study. The file is made up of two parts, an information and contact details part and a survey form part.
Criminal (In)justice in the city and Its associated health consequences.
Creators: name: Golembeski, Cynthia
name: Fullilove, Robert
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 480401
subject: Criminal law
classificationCode: 500106
subject: Medical ethics
classificationCode: 500107
subject: Professional ethics
classificationCode: 420311
subject: Health systems
classificationCode: 440708
subject: Public administration
classificationCode: 420319
subject: Primary health care
classificationCode: 420605
subject: Preventative health care
classificationCode: 440201
subject: Causes and prevention of crime
classificationCode: 420306
subject: Health care administration
classificationCode: 480702
subject: Constitutional law
classificationCode: 440709
subject: Public policy
classificationCode: 440202
subject: Correctional theory, offender treatment and rehabilitation
classificationCode: 420210
subject: Social epidemiology
classificationCode: 420503
subject: Community and primary care

description: The American system of prisons and prisoners— described by its critics as the prison–industrial complex— has grown rapidly since 1970. Increasingly punitive sentencing guidelines and the privatization of prisonrelated industries and services account for much of this growth. Those who enter and leave this system are increasingly Black or Latino, poorly educated, lacking vocational skills, struggling with drugs and alcohol, and disabled. Few correctional facilities mitigate the educational and/ or skills deficiencies of their inmates, and most inmates will return home to communities that are ill equipped to house or rehabilitate them. A more humanistic and community-centered approach to incarceration and rehabilitation may yield more beneficial results for individuals, communities, and, ultimately, society.
Predatory publishers and identity fraud –how to identify dubious providers
Creators: name: Wiorogórska, Zuza
name: Schwesinger, Georg
Publisher: name: Zenodo
Year: 2022
Subjects: predatory journals
predatory publishers
hijacked journals

description: In our presentation, we talk first about the phenomenon of predatory publishers; we present the characteristics of their dishonest and often illegal business model and show some schemes of recognizing and avoiding publishing at predators. Then, we discuss a new emerging challenge for scholarly publishing that is the identity fraud of scientific journals (described as hijacked journals). Those two phenomena might endanger the integrity of scholarly communication by violating the reliability of scholarly publications and hence, deform the image of science and influence badly your research career.
description: Co-funded by the Erasmus+ Programme of the European Union
Altered cortico-striatal signaling and motor behaviour in the YAC128 mouse model of Huntington disease
Creators: name: Koch, Ellen T.
Publisher: name: University of British Columbia
Year: 2022

description: Huntington disease (HD) is a progressive neurodegenerative disorder with no disease-modifying treatments. Patients experience motor, cognitive, and psychiatric disturbances, and the dorsal striatum is the main target of neurodegeneration. Mouse models of HD show altered striatal synaptic signaling in vitro, including changes to cortico-striatal glutamate signaling. Previous studies demonstrate altered glutamate receptor distribution and signaling at cortico-striatal synapses in HD mice, and some studies suggest that glutamate release may be altered, but the presynaptic mechanisms underlying aberrant glutamate release in HD are unknown. Additionally, although changes to striatal signaling have been studied extensively in vitro, it is unclear how these changes correlate with behavioural impairments in vivo. Here, we utilize optogenetic sensors to explore cortico-striatal signaling in HD mice. In acute brain slice, we used iGluSnFR, a modified green fluorescent protein reporter for real-time imaging of glutamate dynamics, to study the presynaptic modulation of glutamate release. We validated iGluSnFR as a valuable tool to accurately measure short- and long-term changes in glutamate release caused by changes to extracellular calcium levels, modulation by presynaptic receptors, and plasticity-inducing stimulation protocols. We confirmed a deficit in HFS-LTD and found changes to D2-receptor-mediated inhibition of glutamate release in YAC128 HD mice. In vivo, we used GCaMP7f, a calcium-sensing fluorescent reporter, to image striatal activity during motor learning on the accelerating rotarod and open field exploration. Mice showed increased neuronal activity on the rotarod, which diminished by late stages of learning. 2–3-month-old YAC128 mice did not show a deficit in latency to fall, but did display significant deficits in paw kinematics, including increased frequency of paw slips. These mice also exhibited aberrant striatal activity during rotarod performance, including a weaker correlation between striatal activity and behaviour. 6–7-month-old YAC128 mice displayed severe rotarod deficits, and elevated striatal activity while on the rotarod. In the open field, YAC128 mice showed increased neuronal activity at rest. Overall, this thesis presents new insights into the mechanisms underlying cortico-striatal glutamate transmission, and alterations to striatal activity associated with behavioural impairments, in mouse models of HD.
Criminal (In)Justice in the City and Its Associated Health Consequences.
Creators: name: Golembeski, Cynthia
name: Fullilove, Robert
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 480401
subject: Criminal law
classificationCode: 500106
subject: Medical ethics
classificationCode: 500107
subject: Professional ethics
classificationCode: 420311
subject: Health systems
classificationCode: 440708
subject: Public administration
classificationCode: 420319
subject: Primary health care
classificationCode: 420605
subject: Preventative health care
classificationCode: 440201
subject: Causes and prevention of crime
classificationCode: 420306
subject: Health care administration
classificationCode: 480702
subject: Constitutional law
classificationCode: 440709
subject: Public policy
classificationCode: 440202
subject: Correctional theory, offender treatment and rehabilitation
classificationCode: 420210
subject: Social epidemiology
classificationCode: 420503
subject: Community and primary care

description: The American system of prisons and prisoners— described by its critics as the prison–industrial complex— has grown rapidly since 1970. Increasingly punitive sentencing guidelines and the privatization of prisonrelated industries and services account for much of this growth. Those who enter and leave this system are increasingly Black or Latino, poorly educated, lacking vocational skills, struggling with drugs and alcohol, and disabled. Few correctional facilities mitigate the educational and/ or skills deficiencies of their inmates, and most inmates will return home to communities that are ill equipped to house or rehabilitate them. A more humanistic and community-centered approach to incarceration and rehabilitation may yield more beneficial results for individuals, communities, and, ultimately, society.
Pseudo-Anosov flows in toroidal manifolds
Creators: name: Barbot, Thierry
name: Fenley, Sergio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Geometric Topology (math.GT)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37D20, 37D50, 57R30, 37D05

description: We first prove rigidity results for pseudo-Anosov flows in prototypes of toroidal 3-manifolds: we show that a pseudo-Anosov flow in a Seifert fibered manifold is up to finite covers topologically equivalent to a geodesic flow and we show that a pseudo-Anosov flow in a solv manifold is topologically equivalent to a suspension Anosov flow. Then we study the interaction of a general pseudo-Anosov flow with possible Seifert fibered pieces in the torus decomposition: if the fiber is associated with a periodic orbit of the flow, we show that there is a standard and very simple form for the flow in the piece using Birkhoff annuli. This form is strongly connected with the topology of the Seifert piece. We also construct a large new class of examples in many graph manifolds, which is extremely general and flexible. We construct other new classes of examples, some of which are generalized pseudo-Anosov flows which have one prong singularities and which show that the above results in Seifert fibered and solvable manifolds do not apply to one prong pseudo-Anosov flows. Finally we also analyse immersed and embedded incompressible tori in optimal position with respect to a pseudo-Anosov flow.
description: 44 pages, 4 figures. Version 2. New section 9: questions and comments. Overall revision, some simplified proofs, more explanations
Density of Complex Critical Points of a Real Random SO(m+1) Polynomials
Creators: name: Macdonald, Brian
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: Complex Variables (math.CV)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 32A60

description: We study the density of complex critical points of a real random SO(m+1) polynomial in m variables. In a previous paper [Mac09], the author used the Poincare- Lelong formula to show that the density of complex zeros of a system of these real random polynomials rapidly approaches the density of complex zeros of a system of the corresponding complex random polynomials, the SU(m+1) polynomials. In this paper, we use the Kac- Rice formula to prove an analogous result: the density of complex critical points of one of these real random polynomials rapidly approaches the density of complex critical points of the corresponding complex random polynomial. In one variable, we give an exact formula and a scaling limit formula for the density of critical points of the real random SO(2) polynomial as well as for the density of critical points of the corresponding complex random SU(2) polynomial.
description: 15 pages
Clauses and Cases in English and Southeast Asian Languages (Burmese, Cambodian, Cantonese, Lao, Thai and Vietnamese) in Contrast
Creators: name: Nguyễn Đăng (Ed.)
Publisher: name: Pacific Linguistics
Year: 1974

description: CLAUSES AND CASES IN ENGLISH AND SOUTHEAST ASIAN LANGUAGES (BURMESE, CAMBODIAN, CANTONESE, LAO, THAI AND VIETNAMESE) IN CONTRAST. 129 0. INTRODUCTION 129 1. CLAUSE UNITS IN THE LANGUAGES 130 1.1. English 131 1.2. Burmese 133 1.3. Cambodian 138 1.4. Cantonese 141 1.5. Lao and Thai 143 1.6. Vietnamese 146 2. CLAUSE UNITS IN CONTRAST 149 2.1. Clause types in contrast 149 2.2. Clause classes in contrast 150 3. DEEP VERSUS SURFACE STRUCTURE 150 4. PHILOSOPHY OF APPROACH 153References 154
Criminal (In)justice in the city and its associated health consequences.
Creators: name: Golembeski, Cynthia
name: Fullilove, Robert
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 480401
subject: Criminal law
classificationCode: 500106
subject: Medical ethics
classificationCode: 500107
subject: Professional ethics
classificationCode: 420311
subject: Health systems
classificationCode: 440708
subject: Public administration
classificationCode: 420319
subject: Primary health care
classificationCode: 420605
subject: Preventative health care
classificationCode: 440201
subject: Causes and prevention of crime
classificationCode: 420604
subject: Injury prevention
classificationCode: 420306
subject: Health care administration
classificationCode: 480702
subject: Constitutional law
classificationCode: 440709
subject: Public policy
classificationCode: 440202
subject: Correctional theory, offender treatment and rehabilitation
classificationCode: 420503
subject: Community and primary care
classificationCode: 420210
subject: Social epidemiology
classificationCode: 440706
subject: Health policy
classificationCode: 440702
subject: Crime policy
classificationCode: 420602
subject: Health equity

description: The American system of prisons and prisoners— described by its critics as the prison–industrial complex— has grown rapidly since 1970. Increasingly punitive sentencing guidelines and the privatization of prisonrelated industries and services account for much of this growth. Those who enter and leave this system are increasingly Black or Latino, poorly educated, lacking vocational skills, struggling with drugs and alcohol, and disabled. Few correctional facilities mitigate the educational and/ or skills deficiencies of their inmates, and most inmates will return home to communities that are ill equipped to house or rehabilitate them. A more humanistic and community-centered approach to incarceration and rehabilitation may yield more beneficial results for individuals, communities, and, ultimately, society.
Additional file 4 of Leveraging gains from African Center for Integrated Laboratory Training to combat HIV epidemic in sub-Saharan Africa
Creators: name: Shrivastava, Ritu
name: Poxon, Richard
name: Rottinghaus, Erin
name: Leyya Essop
name: Sanon, Victoria
name: Zawadi Chipeta
name: Van-Schalkwyk, Elsie
name: Phuti Sekwadi
name: Murangandi, Pelagia
name: Nguyen, Shon
name: Devos, Josh
name: Nesby-Odell, Shanna
name: Stevens, Thomas
name: Umaru, Farouk
name: Cox, Alex
name: Kim, Andrea
name: Chunfu Yang
name: Parsons, Linda M.
name: Babatyi Malope-Kgokong
name: Nkengasong, John N.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 4: Laboratory Information Systems - ACILT Workshop Evaluation Questionnaire.
Exclusive muon-pair productions in ultrarelativistic heavy-ion collisions: Realistic nucleus charge form factor and differential distributions
Creators: name: Klusek-Gawenda, Mariola
name: Szczurek, Antoni
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The cross sections for exclusive muon pair production in nucleus - nucleus collisions are calculated and several differential distributions are shown. Realistic (Fourier transform of charge density) charge form factors of nuclei are used and the corresponding results are compared with the cross sections calculated with monopole form factor often used in the literature and discussed recently in the context of higher-order QED corrections. Absorption effects are discussed and quantified. The cross sections obtained with realistic form factors are significantly smaller than those obtained with the monopole form factor. The effect is bigger for large muon rapidities and/or large muon transverse momenta. The predictions for the STAR and PHENIX collaboration measurements at RHIC as well as the ALICE and CMS collaborations at LHC are presented.
description: 26 pages, 35 figures, figures and discussion added
Additional file 1: of The effect of the cholinergic anti-inflammatory pathway on collagen-induced arthritis involves the modulation of dendritic cell differentiation
Creators: name: Liu, Di
name: Li, Tong
name: Luo, Hui
name: Zuo, Xiaoxia
name: Liu, Sijia
name: Wu, Shiyao
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Bone marrowâ derived dendritic cells (BMDCs) were stained with antibodies against F4/80, CD11c, CD80 and major histocompatibility complex II (MHC II) and analyzed by flow cytometry. Frequency of CD11c+ F4/80â cells was analyzed by flow cytometry. The number in the upper right represents the percentage of CD11c+ F4/80+ cells, which is less than 5%. (DOCX 50 kb)
Numerical tools to validate stationary points of SO(8)-gauged N=8 D=4 supergravity
Creators: name: Fischbacher, Thomas
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Until recently, the preferred strategy to identify stationary points in the scalar potential of SO(8)-gauged N=8 supergravity in D=4 has been to consider truncations of the potential to sub-manifolds of E_{7(+7)}/SU(8) that are invariant under some postulated residual gauge group G of SO(8). As powerful alternative strategies have been shown to exist that allow one to go far beyond what this method can achieve -- and in particular have produced numerous solutions that break the SO(8) gauge group to no continuous residual symmetry -- independent verification of results becomes a problem due to both the complexity of the scalar potential and the large number of new solutions. This article introduces a conceptually simple self-contained piece of computer code that allows independent numerical validation of claims on the locations of newly discovered stationary points.
description: 9 pages, program code can be obtained by downloading paper's source from arxiv; new version contains code cleanup and extensions (scalar mass matrix code)
Discrete Data Assimilation in the Lorenz and 2D Navier--Stokes Equations
Creators: name: Hayden, Kevin
name: Olson, Eric
name: Titi, Edriss S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 76 Fluid mechanics

description: Consider a continuous dynamical system for which partial information about its current state is observed at a sequence of discrete times. Discrete data assimilation inserts these observational measurements of the reference dynamical system into an approximate solution by means of an impulsive forcing. In this way the approximating solution is coupled to the reference solution at a discrete sequence of points in time. This paper studies discrete data assimilation for the Lorenz equations and the incompressible two-dimensional Navier--Stokes equations. In both cases we obtain bounds on the time interval h between subsequent observations which guarantee the convergence of the approximating solution obtained by discrete data assimilation to the reference solution.
Berufliche Neuorientierung mit 50plus - Utopie? : Erkenntnisse für die Laufbahnberatung
Creators: name: Zurfluh, Martha
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2016
Subjects: 158: Angewandte Psychologie
650: Management

description: Dass auch mit 50plus noch berufliche Neuausrichtungen stattfinden, scheint ein sich in den letzten Jahren neu entwickeltes Phänomen zu sein, das unterschiedliche Ursachen hat. Zu nennen ist hier einerseits der Wunsch oder das Bedürfnis dieser Altersgruppe, in einem anderen Arbeitsmodell, in einer anderen Funktion oder gar anderen Tätigkeit und in einem neuen Unternehmen tätig zu sein. Aufgrund sich schnell ändernden Arbeitsmarkt-Situationen, z.B. in Form von Umstrukturierungen, Wegrationalisierung oder Verlagerung des Arbeitsplatzes ins Ausland aber auch durch strukturelle Veränderungen, werden heute ältere Mitarbeitende nicht selten dazu gezwungen, sich vor der Pensionierung nochmals neu zu orientieren und zu positionieren. Anderseits wird aufgrund der demografischen Entwicklung eine längere Einbindung der älteren Generation von Politik, Gesellschaft und Arbeitswelt gefordert, um weiterhin wirtschaftlich sein zu können und dem sich in vielen Bereichen abzeichnenden Fachkräftemangel entgegenzuwirken.
Criminal (In)justice in the city and Iis associated health consequences.
Creators: name: Golembeski, Cynthia
name: Fullilove, Robert
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 480401
subject: Criminal law
classificationCode: 500106
subject: Medical ethics
classificationCode: 500107
subject: Professional ethics
classificationCode: 420311
subject: Health systems
classificationCode: 440708
subject: Public administration
classificationCode: 420319
subject: Primary health care
classificationCode: 420605
subject: Preventative health care
classificationCode: 440201
subject: Causes and prevention of crime
classificationCode: 420604
subject: Injury prevention
classificationCode: 420306
subject: Health care administration
classificationCode: 480702
subject: Constitutional law
classificationCode: 440709
subject: Public policy
classificationCode: 440202
subject: Correctional theory, offender treatment and rehabilitation
classificationCode: 420503
subject: Community and primary care
classificationCode: 420210
subject: Social epidemiology
classificationCode: 440706
subject: Health policy
classificationCode: 440702
subject: Crime policy
classificationCode: 420602
subject: Health equity

description: The American system of prisons and prisoners— described by its critics as the prison–industrial complex— has grown rapidly since 1970. Increasingly punitive sentencing guidelines and the privatization of prisonrelated industries and services account for much of this growth. Those who enter and leave this system are increasingly Black or Latino, poorly educated, lacking vocational skills, struggling with drugs and alcohol, and disabled. Few correctional facilities mitigate the educational and/ or skills deficiencies of their inmates, and most inmates will return home to communities that are ill equipped to house or rehabilitate them. A more humanistic and community-centered approach to incarceration and rehabilitation may yield more beneficial results for individuals, communities, and, ultimately, society.
Herausforderung alpiner Renaturierungen : markante Unterschiede in Vegetation, Bakterien und Boden
Creators: name: Blank-Pachlatko, Jonathan
name: Kulli Honauer, Beatrice
name: Edelkraut, Kirsten
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2023
Subjects: Renaturierung
Vegetation
Boden
Bodenbakterien
333.7: Landflächen, Naturerholungsgebiete

description: Die Schweiz weist mit ihrer abwechslungsreichen Topografie eine hohe Artenvielfalt auf. Die heterogene Landschaft und insbesondere die mächtigen Gebirgszüge tragen dabei zur besonderen Verantwortung gegenüber dem Schutz und Erhalt der Biodiversität bei. Bautätigkeiten und Eingriffe in die Landschaft ausserhalb der Bauzonen werden daher häufig von Renaturierungsmassnahmen begleitet. Jonathan Blank-Pachlatko untersuchte in seiner Masterarbeit am Corvatsch im Engadin, welche ökologischen Unterschiede sich dabei kurz nach der Ausführung im Vergleich zu unberührten Flächen feststellen liessen.
Harninkontinenz bei COPD
L’incontinence urinaire en cas de BPCO
Creators: name: Köhler, Barbara
name: Ernst, Anja
Publisher: name: Physioswiss
Year: 2016
Subjects: Harninkontinenz
Physiotherapie
616: Innere Medizin und Krankheiten

description: Harninkontinenz ist bei COPD-PatientInnen sehr häufig. Deshalb sollte in der Atmungs- und Trainingstherapie der Beckenboden routinemässig integriert werden.
description: L’incontinence urinaire est très fréquente chez les patients atteints de BPCO. C’est pourquoi la rééducation du plancher pelvien devrait faire systématiquement partie du traitement et de la réadaptation respiratoire.
title: Trace amine-associated receptor 1 activation regulates glucose-dependent insulin secretion in pancreatic beta cells in vitro
Creators: name: Kumar, Arun
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: Trace amines are a group of endogenous monoamines which exert their action through a family of G protein-coupled receptors known as trace amine-associated receptors (TAARs). TAAR1 has been reported to regulate insulin secretion from pancreatic beta cells in vitro and in vivo. This study investigates the mechanism(s) by which TAAR1 regulates insulin secretion. The insulin secreting rat INS-1E -cell line was used for the study. Cells were pre-starved (30 minutes) and then incubated with varying concentrations of glucose (2.5 – 20 mM) or KCl (3.6 – 60 mM) for 2 hours in the absence or presence of various concentrations of the selective TAAR1 agonist RO5256390. Secreted insulin per well was quantified using ELISA and normalized to the total protein content of individual cultures. RO5256390 significantly (P < 0.0001) increased glucose-stimulated insulin secretion in a dose-dependent manner, with no effect on KCl-stimulated insulin secretion. Affymetrix-microarray data analysis identified genes (Gnas, Gng7, Gngt1, Gria2, Cacna1e, Kcnj8, and Kcnj11) whose expression was associated with changes in TAAR1 in response to changes in insulin secretion in pancreatic beta cell function. The identified potential links to TAAR1 supports the regulation of glucose-stimulated insulin secretion through KATP ion channels.
Views of dental providers on primary care coordination at chairside: A pilot study
Creators: name: Northridge, M.E.
name: Birenz, S.
name: Gomes, D.M.
name: Golembeski, Cynthia
name: Greenblatt, A.P.
name: Shelley, D.
name: Russell, S.L.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320399
subject: Dentistry not elsewhere classified
classificationCode: 420699
subject: Public health not elsewhere classified
classificationCode: 420312
subject: Implementation science and evaluation
classificationCode: 350307
subject: Technology management
classificationCode: 420308
subject: Health informatics and information systems
classificationCode: 461009
subject: Recordkeeping informatics
classificationCode: 420503
subject: Community and primary care
classificationCode: 500106
subject: Medical ethics
classificationCode: 420319
subject: Primary health care
classificationCode: 420605
subject: Preventative health care

description: Purpose: There is a need for research to facilitate the widespread implementation, dissemination, and sustained utilization of evidence-based primary care screening, monitoring, and care coordination guidelines, thereby increasing the impact of dental hygienists’ actions on patients’ oral and general health. The aims of this formative study are to: (1) explore dental hygienists’ and dentists’ perspectives regarding the integration of primary care activities into routine dental care; and (2) assess the needs of dental hygienists and dentists regarding primary care coordination activities and use of information technology to obtain clinical information at chairside.Methods: This qualitative study recruited ten hygienists and six dentists from ten New York City area dental offices with diverse patient mixes and volumes. A New York University faculty hygienist conducted semi-structured, in-depth interviews, which were digitally recorded and transcribed verbatim. Data analysis consisted of multilevel coding based on the Consolidated Framework for Implementation Research, resulting in emergent themes with accompanying categories.Results: The dental hygienists and dentists interviewed as part of this study fail to use evidence-based guidelines to screen their patients for primary care sensitive conditions. Overwhelmingly, dental providers believe that tobacco use and poor diet contribute to oral disease, and report using electronic devices at chairside to obtain web-based health information.Conclusion: Dental hygienists are well positioned to help facilitate greater integration of oral and general health care. Challenges include lack of evidence-based knowledge, coordination between dental hygienists and dentists, and systems-level support, with opportunities for improvement based upon a theory-driven framework.
Additional file 2 of Platelet-to-lymphocyte ratio and the first occurrence of peritonitis in peritoneal dialysis patients
Creators: name: Su, Ning
name: Zheng, Yijia
name: Zhang, Xing
name: Tang, Xingming
name: Tang, Li-wen
name: Wang, Qinqin
name: Chen, Xingyu
name: Wang, Xiaoyang
name: Wen, Yueqiang
name: Feng, Xiaoran
name: Zhou, Qian
name: Zhou, Jiafan
name: Li, Yafang
name: Shang, Sijia
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Additional file 2.
Additional file 1 of Leveraging gains from African Center for Integrated Laboratory Training to combat HIV epidemic in sub-Saharan Africa
Creators: name: Shrivastava, Ritu
name: Poxon, Richard
name: Rottinghaus, Erin
name: Leyya Essop
name: Sanon, Victoria
name: Zawadi Chipeta
name: Van-Schalkwyk, Elsie
name: Phuti Sekwadi
name: Murangandi, Pelagia
name: Nguyen, Shon
name: Devos, Josh
name: Nesby-Odell, Shanna
name: Stevens, Thomas
name: Umaru, Farouk
name: Cox, Alex
name: Kim, Andrea
name: Chunfu Yang
name: Parsons, Linda M.
name: Babatyi Malope-Kgokong
name: Nkengasong, John N.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: HIV-1 Early Infant Diagnosis and/or Viral Load Testing Training Course - Participant Questionnaire.
title: Software Engineering for Computational Science
Creators: name: Johanson, Arne
name: Hasselbring, Wilhelm
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2019
Subjects: subject: Computational Science
subject: Model-driven software engineering
subject: Software architecture

description: Despite the increasing importance of in silico experiments to the scientific discovery process, state-of-the-art software engineering practices are rarely adopted in computational science. To understand the underlying causes for this situation and to identify ways to improve it, we conducted a literature survey on software engineering practices in computational science. We identified recurring key characteristics of scientific software development that are the result of the nature of scientific challenges, the limitations of computers, and the cultural environment of scientific software development. Our findings allow us to point out shortcomings of existing approaches for bridging the gap between software engineering and computational science and to provide an outlook on promising research directions that could contribute to improving the current situation.
Generalizable deep learning models for epithelial ovarian carcinoma classification
Creators: name: Boschman, Jeffrey
Publisher: name: University of British Columbia
Year: 2022

description: Ovarian carcinoma is the deadliest cancer of the female reproductive system in North America. There are five major histological subtypes which require different treatments. Pathologists diagnose these histotypes by examining hematoxylin and eosin (H&E)-stained whole slide images (WSIs) of tissue. However, histotype diagnosis is not simple, with poor interobserver agreement between general pathologists (Cohen’s kappa 0.54-0.67). We hypothesize that latest machine learning (ML)-based image classification models may be able to recognize ovarian carcinoma histotype sufficiently well that they could aid pathologists in diagnosis. However, the color variation of H&E-stained tissues, especially those from different centers/hospitals, is a longstanding challenge for applications of AI in digital pathology. First, we investigate eight color normalization algorithms as a preprocessing step for artificial intelligence (AI)-based classification. Using multiple datasets of different cancer types, reference images, and cross-validation splits, we show that color normalization significantly improves the classification accuracy of WSIs when the train and test data are from separate institutions (ovarian cancer: 0.25 AUC increase, p = 1.6 e-05, pleural cancer: 0.21 AUC increase, p = 1.4 e-10). Furthermore, we introduce a novel augmentation strategy by mixing color-normalized images using three easily accessible algorithms that consistently improves the diagnosis of test images from external institutions. Secondly, we train four different deep convolutional neural networks to automatically classify H&E-stained images of epithelial ovarian carcinoma using the largest training dataset to date (948 slides corresponding to 485 patients). Performance is assessed on an independent test set of 60 patients from another institution. The best performing model achieves a mean diagnostic concordance of 80.97% (Cohen’s kappa 0.7547). As well, in 4 of 8 cases misclassified by ML from the external dataset, two expert subspecialty pathologists rendered diagnoses, based on blind review of the WSIs, that agree with AI rather than the integrated reference diagnosis. Our results indicate that color normalization can reliably improve AI-based diagnosis of WSIs sourced from multiple centers, and specifically that an ML-based ovarian carcinoma classifier is ready for clinical validation studies as an adjunct for informing histotype diagnosis, thereby supporting histotype-specific ovarian cancer treatment and accordingly reduce the deadliness of this disease.
Modern Linguistic Theories and Contrastive Analysis of English and Vietnamese
Creators: name: Nguyễn Đăng (Ed.)
Publisher: name: Pacific Linguistics
Year: 1974

description: MODERN LINGUISTIC THEORIES AND CONTRASTIVE ANALYSIS OF ENGLISH AND VIETNAMESE. 111 0. INTRODUCTION 111 1. TAGMEMICS AND PRE-ASPECTS TRANSFORMATIONAL PROCEDURE 114 1.1. Clause types in contrast 115 1.2. Clause classes in contrast 119 2. CASE GRAMMAR 122 3. GENERATIVE TRANSFORMATIONAL INSIGHTS 124 4. STATISTICAL STUDIES 124 5. THEORETICAL CONSIDERATIONS 125References 126
Views of Dental Providers on Primary Care Coordination at Chairside: A Pilot Study
Creators: name: Northridge, M.E.
name: Birenz, S.
name: Gomes, D.M.
name: Golembeski, Cynthia
name: Greenblatt, A.P.
name: Shelley, D.
name: Russell, S.L.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320399
subject: Dentistry not elsewhere classified
classificationCode: 420699
subject: Public health not elsewhere classified
classificationCode: 420312
subject: Implementation science and evaluation
classificationCode: 350307
subject: Technology management
classificationCode: 420308
subject: Health informatics and information systems
classificationCode: 461009
subject: Recordkeeping informatics
classificationCode: 420503
subject: Community and primary care
classificationCode: 500106
subject: Medical ethics
classificationCode: 420319
subject: Primary health care
classificationCode: 420605
subject: Preventative health care

description: Purpose: There is a need for research to facilitate the widespread implementation, dissemination, and sustained utilization of evidence-based primary care screening, monitoring, and care coordination guidelines, thereby increasing the impact of dental hygienists’ actions on patients’ oral and general health. The aims of this formative study are to: (1) explore dental hygienists’ and dentists’ perspectives regarding the integration of primary care activities into routine dental care; and (2) assess the needs of dental hygienists and dentists regarding primary care coordination activities and use of information technology to obtain clinical information at chairside.Methods: This qualitative study recruited ten hygienists and six dentists from ten New York City area dental offices with diverse patient mixes and volumes. A New York University faculty hygienist conducted semi-structured, in-depth interviews, which were digitally recorded and transcribed verbatim. Data analysis consisted of multilevel coding based on the Consolidated Framework for Implementation Research, resulting in emergent themes with accompanying categories.Results: The dental hygienists and dentists interviewed as part of this study fail to use evidence-based guidelines to screen their patients for primary care sensitive conditions. Overwhelmingly, dental providers believe that tobacco use and poor diet contribute to oral disease, and report using electronic devices at chairside to obtain web-based health information.Conclusion: Dental hygienists are well positioned to help facilitate greater integration of oral and general health care. Challenges include lack of evidence-based knowledge, coordination between dental hygienists and dentists, and systems-level support, with opportunities for improvement based upon a theory-driven framework.
Additional file 2 of Leveraging gains from African Center for Integrated Laboratory Training to combat HIV epidemic in sub-Saharan Africa
Creators: name: Shrivastava, Ritu
name: Poxon, Richard
name: Rottinghaus, Erin
name: Leyya Essop
name: Sanon, Victoria
name: Zawadi Chipeta
name: Van-Schalkwyk, Elsie
name: Phuti Sekwadi
name: Murangandi, Pelagia
name: Nguyen, Shon
name: Devos, Josh
name: Nesby-Odell, Shanna
name: Stevens, Thomas
name: Umaru, Farouk
name: Cox, Alex
name: Kim, Andrea
name: Chunfu Yang
name: Parsons, Linda M.
name: Babatyi Malope-Kgokong
name: Nkengasong, John N.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file2: HIV-1 Drug Resistance Interpretation in Sequence Editing and Data Management Processes Training Course - Participant Questionnaire.
Interacting entropy-corrected holographic scalar field models in non-flat universe
Creators: name: Khodam-Mohammadi, A.
name: Malekjani, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work we establish a correspondence between the tachyon, K-essence and dilaton scalar field models with the interacting entropy-corrected holographic dark (ECHD) model in non-flat FRW universe. The reconstruction of potentials and dynamics of these scalar fields according to the evolutionary behavior of the interacting ECHDE model are be done. It has been shown that the phantom divide can not be crossed in ECHDE tachyon model while it is achieved for ECHDE K-essence and ECHDE dilaton scenarios. At last we calculate the limiting case of interacting ECHDE model, without entropy-correction.
description: 15 pages, no figure, Some Refs. are added, typos corrected, to be published by CTP (2011)
title: Supporting Semi-Automatic Co-Evolution of Architecture and Fault Tree Models
Creators: name: Getir, Sinem
name: van Hoorn, André
name: Kehrer, Timo
name: Noller, Yannic
name: Tichy, Matthias
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2019
Subjects: subject: System architecture
subject: fault trees
subject: safety
subject: model co-evolution
subject: model transformation

description: In this work, we report about recent research results on “Supporting Semi-Automatic Co-Evolution of Architecture and Fault Tree Models”, published in [Ge18]. During the whole life-cycle of software-intensive systems in safety-critical domains, system models must consistently co-evolve with quality evaluation models. However, performing the necessary synchronization steps is a cumbersome and often manual task prone to errors. To understand this problem in detail, we have analyzed the evolution of two representatives of system models and quality evaluation models, namely architecture and fault tree models, for a set of evolution scenarios of a factory automation system called Pick and Place Unit. We designed a set of intra- and inter-model transformation rules which fully cover the evolution scenarios of the case study and which offer the potential to semi-automate the co-evolution process. In particular, we validated these rules with respect to completeness and evaluated them by a comparison to typical visual editor operations. Our results show a significant reduction of the amount of required user interactions in order to realize the co-evolution.
Additional file 1: of Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis
Creators: name: Wang, Ye
name: Wu, Meijuan
name: Lei, Zengjie
name: Huang, Mengxi
name: Li, Zhiping
name: Wang, Liya
name: Cao, Qijun
name: Han, Dong
name: Chang, Yue
name: Chen, Yanyan
name: Liu, Xiaobei
name: Xue, Lijun
name: Mao, Xiaobei
name: Geng, Jian
name: Chen, Yanan
name: Dai, Tingting
name: Ren, Lili
name: Wang, Qian
name: Yu, Hongju
name: Chen, Cheng
name: Chu, Xiaoyuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Figure S1. (A) qRT-PCR analysis of the expression of indicated miRNAs in HCT8 and HCT116 cells. (B & C) Transfection efficiency was measured by qRT-PCR. *p < 0.05, **p < 0.01. Figure S2. (A) Western blot analysis of FOXM1 expression in HCT116 cells transfected with empty control vector or FOXM1 expressing plasmid. (B) HUVECswere treatedwith the CM from indicated cells, and subjected to wound healing assay. Scale bar = 20 μm. (C) Xenografted tumors were excised at week 3 post the inoculation, and the tumor weight from different groups was compared. (D) Western blot analysis of FOXM1 expression in HCT116 cells transfected with shNC, sh1 and sh2 against FOXM1. (E) HUVECs were treated with the CM from HCT116 cells transfected with indicated vectors. Cell viability of HUVECs was measured by CCK8 assay. (F) HUVECs were co-cultured with HCT116 cells transfected with indicated vectors in transwell apparatus. Migrated HUVECs were quantified after co-culture for 24 h. Scale bar = 20 μm. (G) HUVECs were treated with the CM from indicated cells, and subjected to tube formation assay. Scale bar = 20 μm. *p < 0.05, **p < 0.01. Figure S3. The bivariate relation between the mRNA levels of FOXM1 and IL-8 in CRC samples from GEO dataset was assessed by Pearson’s correlation test. Figure S4. (A) qRT-PCR analysis of pre-miR-6868 expression in HCT116 cells with FOXM1 overexpression. (B) HCT8 and HCT116 cells were treated with 5-Azd (10 μM). The miR-6868-5p levels were examined by qRT-PCR after 48 h. miR-375 was used as positive control. (C) Western blot analysis of H3K27me3 expression in HCT116 cells upon GSK126 treatment. *p < 0.05, **p < 0.01. Figure S5. (A) The bivariate relation between the EXOC7 mRNA levels and miR-6868-5p levels in CRC samples was assessed by Pearson’s correlation test. (B) qRT-PCR analysis of pre-miR-6868 and miR-6868-5p expression in cells transfected with siNC or siDrosha. (C) qRT-PCR analysis of EXOC7 expression in HCT116 cells with FOXM1 overexpression. Table S1. Number of predicted binding sites in FOXM1 3’-UTR. Table S2. Sequences of primers used for qRT-PCR in this study. Table S3. Sequences of primers used for ChIP-qPCR in this study. Table S4. Correlation between miR-6868-5p expression and TNM stage in CRC samples. (DOCX 12322 kb)
General Electric Quarterly Survey 73-02, Versions I & II, Prof. & Manag., I & II, College Student
Creators: name: Electric, General
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Adult sample: Most interesting concern (1); race relations (1); future race relations (1); companies helping race relations (1); transportation problem (1); local power plant (1); need for power plants (1); unaffordable purchases (1); car usage (1); automobile restrictions (2); gasoline engine alternatives (5); government activity changes (8); increased taxes approval (6); discussing national issues (2); company effects (1); most important space developments (1); time spent with news (1); college attended (2); class year (1); major (1); degree (1); preferred career (2); importance of career aspects (8); class standing (2). College student sample: Most interesting concern (1); local community interests (1); race relations (1); future race relations (1); companies helping race relations (1); transportation problem (1); noise problem (1); price controls (1); wage controls (1); unaffordable purchases (1); luxuries (4); local power plant (1); need for power plants (1); reducing electric power (2); car usage (1); automobile restrictions (2); gasoline engine alternatives (5); government activity changes (14); increased taxes approval (12); discussing national issues (2); company effects (1); company activity disapproval (5); reading habits (1); time spent with news (1); income changes (1); price changes (4); financial situation (1); spending habits (7).