title: Ð£ÑÐ°ÑÑÐ¸Ðµ D2 ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð° Ð² ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ NO-ÐµÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¿ÑÐ¸Ð»ÐµÐ¶Ð°ÑÐµÐ³Ð¾ ÑÐ´ÑÐ° (n. accumbens)
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ»ÐµÐºÑÐµÐµÐ²Ð°, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¾ÐºÑÐ¸Ð´ Ð°Ð·Ð¾ÑÐ°
D2 ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð°
NMDA ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ°
Ð¿ÑÐ¸Ð»ÐµÐ¶Ð°ÑÐµÐµ ÑÐ´ÑÐ¾
Ð²Ð½ÑÑÑÐ¸Ð¼Ð¾Ð·Ð³Ð¾Ð²Ð¾Ð¹ Ð¼Ð¸ÐºÑÐ¾Ð´Ð¸Ð°Ð»Ð¸Ð·
nitric oxide
dopamine D2 receptors
NMDA receptors
nucleus accumbens
intracerebral microdialysis

description: ÐÐ¾ÑÑÐµÐ´ÑÑÐ²Ð¾Ð¼ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¸Ð¶Ð¸Ð·Ð½ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð²Ð½ÑÑÑÐ¸Ð¼Ð¾Ð·Ð³Ð¾Ð²Ð¾Ð³Ð¾ Ð¼Ð¸ÐºÑÐ¾Ð´Ð¸Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð²ÑÑÐ¾ÐºÐ¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ½Ð¾Ð¹ ÑÑÐ¾Ð¼Ð°ÑÐ¾Ð³ÑÐ°ÑÐ¸Ð¸ Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð´ÐµÑÐµÐºÑÐ¸ÐµÐ¹ Ð½Ð° ÐºÑÑÑÐ°Ñ Ð»Ð¸Ð½Ð¸Ð¸ Ð¡Ð¿ÑÐµÐ³-ÐÐ¾ÑÐ»Ð¸ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸ÑÑ Ð² Ð¿ÑÐ¸Ð»ÐµÐ¶Ð°ÑÐµÐµ ÑÐ´ÑÐ¾ ÑÐ°ÐºÐ»Ð¾Ð¿ÑÐ°Ð¹Ð´Ð° (Ð°Ð½ÑÐ°Ð³Ð¾Ð½Ð¸ÑÑÐ° D2 ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð°) Ð² ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸ÑÑ 20 Ð¼ÐºÐ Ð¸ 100 Ð¼ÐºÐ Ð²Ð½ÐµÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐ¹ ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐ¾Ð¿ÑÐ¾Ð´ÑÐºÑÐ° ÑÐ¸Ð½ÑÐµÐ·Ð° NO ÑÐ¸ÑÑÑÐ»Ð»Ð¸Ð½Ð° Ð½Ðµ Ð¸Ð·Ð¼ÐµÐ½ÑÐµÑÑÑ Ð¸ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ ÑÐ¾Ð½Ð¾Ð²ÑÐ¼ Ð·Ð½Ð°ÑÐµÐ½Ð¸ÑÐ¼. ÐÐ²ÐµÐ´ÐµÐ½Ð¸Ñ Ð² ÑÑ Ð¶Ðµ ÑÑÑÑÐºÑÑÑÑ NMDA (Ð°Ð³Ð¾Ð½Ð¸ÑÑÐ° NMDA ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ°) Ð² ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ 100 Ð¼Ð Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº ÑÐ¾ÑÑÑ ÑÑÐ¾Ð²Ð½Ñ Ð²Ð½ÐµÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸ÑÑÑÐ»Ð»Ð¸Ð½Ð° Ð² ÑÑÐ¾Ð¹ ÑÑÑÑÐºÑÑÑÐµ. ÐÐ´Ð½Ð°ÐºÐ¾ Ð½Ð° ÑÐ¾Ð½Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾ÑÐ° NO-ÑÐ¸Ð½ÑÐ°Ð·Ñ (ÐµÐµ Ð½ÐµÐ¹ÑÐ¾Ð½Ð½Ð¾Ð¹ Ð¸Ð·Ð¾ÑÐ¾ÑÐ¼Ñ) 7-Ð½Ð¸ÑÑÐ¾Ð¸Ð½Ð´Ð°Ð·Ð¾Ð»Ð° Ð² ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ 0.5 Ð¼Ð Ð¿Ð¾Ð´ÑÐµÐ¼, Ð²ÑÐ·ÑÐ²Ð°ÐµÐ¼ÑÐ¹ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸ÑÐ¼Ð¸ NMDA, Ð½Ðµ Ð²Ð¾Ð·Ð½Ð¸ÐºÐ°ÐµÑ. Ð¡Ð¾Ð²Ð¼ÐµÑÑÐ½Ð¾Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ NMDA Ð¸ ÑÐ°ÐºÐ»Ð¾Ð¿ÑÐ°Ð¹Ð´Ð° Ð² ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸ÑÑ 20 Ð¼ÐºÐ Ð¸ 100 Ð¼ÐºÐ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð´ÑÐµÐ¼Ð° Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸ÑÐ¼Ð¸ NMDA. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ Ð² Ð¿ÑÐ¸Ð»ÐµÐ¶Ð°ÑÐµÐ¼ ÑÐ´ÑÐµ D2 ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð° Ð¿ÑÐ¸Ð½Ð¸Ð¼Ð°ÑÑ ÑÑÐ°ÑÑÐ¸Ðµ Ð² ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½ÐµÐ¹ÑÐ¾Ð½Ð½Ð¾Ð¹ NO-ÑÐ¸Ð½ÑÐ°Ð·Ñ, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð²ÑÐ·ÑÐ²Ð°ÐµÑÑÑ Ð»Ð¾ÐºÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸ÐµÐ¹ NMDA ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ°.
description: In vivo intracerebral microdialysis and high-performance liquid chromatography with electrochemical detection studies in Sprague-Dawley rats showed that injection of raclopride (dopamine D2 receptor antagonist) in concentrations of 20 Î¼M and 100 Î¼M into the nucleus accumbens did not alter the baseline extracellular citrulline level (a co-product of NO synthesis). Administration of 100 Î¼M NMDA (NMDA glutamate receptor agonist) into the same structure induced an increase in the extracellular citrulline level. This increase was prevented by intraaccumbal infusion of 0.5mM 7-nitroindazole, a neuronal NO-synthase inhibitor, and it was significantly reduced by the infusion of raclopride (20 ÂµM, 100 ÂµM) into this brain area. These data allow to suppose that dopamine D2 receptors of the nucleus accumbens are involved in the regulation of neuronal NO-synthase activity induced by local NMDA receptor stimulation.