Additional file 1 of Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials
Creators: name: Elmakaty, Ibrahim
name: Abdo, Ruba
name: Elsabagh, Ahmed
name: Elsayed, Abdelrahman
name: Malki, Mohammed Imad
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Cancer
Science Policy

description: Additional file 1: Table S1: PRISMA checklist for this network meta-analysis. Table S2: Excluded articles at full-text screening. Table S3: Overall survival treatment ranking and surface under the cumulative ranking curve. Figure S1: Overall survival using generalized pairwise modelling. Table S4: Progression free survival treatment ranking and surface under the cumulative ranking curve. Figure S2: Progression free survival using generalized pairwise modelling. Table S5: Pathologic complete response treatment ranking and surface under the cumulative ranking curve. Figure S3: Pathologic complete response using generalized pairwise modelling. Table S6: Adverse events grade ≥ 3 treatment ranking and surface under the cumulative Table. Figure S4: Adrenal insufficiency odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S5: Diarrhea odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S6: Hyperthyroidism odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S7: Hypothyroidism odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S8: Infusion reaction odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S9: Pneumonitis odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S10: Anemia odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S11: Colitis odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S12: Fatigue odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S13: Nausea odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S14: Neutropenia odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S15: Rash odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S16: Vomiting odds network meta-analysis results. A Schematic diagram showing the network map for the treatments included in the analysis. B Rankogram showing the ranking probabilities for the least odds of causing this adverse event for each treatment. C Forest plot showing each trial effect size and confidence interval as well as the pooled effect size. D Bias-adjusted funnel plot showing each treatment separately. Figure S17: Adverse events grade ≥ 3 using generalized pairwise modelling. Table S7: Extracted data used for the analysis.