cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway
Creators: name: Jin, Nianqiang
name: Wang, Binhang
name: Liu, Xinyao
name: Yin, Chengcheng
name: Li, Xing
name: Wang, Zilin
name: Chen, Xi
name: Liu, Yunling
name: Bu, Wenhuan
name: Sun, Hongchen
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
Curvature-Induced Instabilities of Shells
Creators: name: Pezzulla, Matteo
name: Stoop, Norbert
name: Steranka, Mark P.
name: Bade, Abdikhalaq J.
name: Holmes, Douglas P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Induced by proteins within the cell membrane or by differential growth, heating, or swelling, spontaneous curvatures can drastically affect the morphology of thin bodies and induce mechanical instabilities. Yet, the interaction of spontaneous curvature and geometric frustration in curved shells remains still poorly understood. Via a combination of precision experiments on elastomeric spherical bilayer shells, simulations, and theory, we show a spontaneous curvature-induced rotational symmetry-breaking as well as a snapping instability reminiscent of the Venus fly trap closure mechanism. The instabilities and their dependence on geometry are rationalized by reducing the spontaneous curvature to an effective mechanical load. This formulation reveals a combined pressurelike bulk term and a torquelike boundary term, allowing scaling predictions for the instabilities in excellent agreement with experiments and simulations. Moreover, the effective pressure analogy suggests a curvature-induced buckling in closed shells. We determine the critical buckling curvature via a linear stability analysis that accounts for the combination of residual membrane and bending stresses. The prominent role of geometry in our findings suggests the applicability of the results over a wide range of scales.
description: 12 pages, 9 figures (including Supporting Information)
Probability tilting of compensated fragmentations
Creators: name: Shi, Quan
name: Watson, Alexander R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G51, 60J25, 60J80, 60G55

description: Fragmentation processes are part of a broad class of models describing the evolution of a system of particles which split apart at random. These models are widely used in biology, materials science and nuclear physics, and their asymptotic behaviour at large times is interesting both mathematically and practically. The spine decomposition is a key tool in its study. In this work, we consider the class of compensated fragmentations, or homogeneous growth-fragmentations, recently defined by Bertoin. We give a complete spine decomposition of these processes in terms of a Lévy process with immigration, and apply our result to study the asymptotic properties of the derivative martingale.
description: 41 pages, 1 figure. This revised version improves the conditions in Theorem 6.1
Rotation in [CII]-emitting gas in two galaxies at a redshift of 6.8
Creators: name: Smit, Renske
name: Bouwens, Rychard J.
name: Carniani, Stefano
name: Oesch, Pascal A.
name: Labbé, Ivo
name: Illingworth, Garth D.
name: van der Werf, Paul
name: Bradley, Larry D.
name: Gonzalez, Valentino
name: Hodge, Jacqueline A.
name: Holwerda, Benne W.
name: Maiolino, Roberto
name: Zheng, Wei
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The earliest galaxies are expected to emerge in the first billion years of the Universe during the Epoch of Reionization. However, both the spectroscopic confirmation of photometrically-selected galaxies at this epoch and the characterization of their early dynamical state has been hindered by the lack of bright, accessible lines to probe the velocity structure of their interstellar medium. We present the first ALMA spectroscopic confirmation of such sources at z > 6 using the far-infrared [C II]λ157.74μm emission line, and, for the first time, measurement of the velocity structure, for two galaxies at z = 6.8540+/-0.0003 and z = 6.8076+/-0.0002. Remarkably, the [C II] line luminosity from these galaxies is higher than previously found in `normal' star-forming galaxies at z > 6.5. This suggests that we are sampling a part of the galaxy population different from the galaxies found through detection of the Lyα line. The luminous and extended [C II] detections reveal clear velocity gradients that, if interpreted as rotation, would suggest these galaxies have turbulent, yet rotation-dominated disks, with similar stellar-to-dynamical mass fractions as observed for Hα emitting galaxies 2 Gyr later at cosmic noon. Our novel approach for confirming galaxies during Reionization paves the way for larger studies of distant galaxies with spectroscopic redshifts from ALMA. Particularly important, this opens up opportunities for high angular-resolution [C II] dynamics in galaxies less than one billion years after the Big Bang.
description: 14 pages, 5 figures, 1 table, published in Nature (submitted version)
title: Affiche Atelier du numérique "Edit-a-thon"
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Atelier réalisé par Véronique Ginouvès (USR 3125/MMSH).
The Intra-Tumour Heterogeneity Landscape of Human Cancers
Creators: name: Dentro, Stefan Christiaan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Cancer
Sequencing
Copy Number Alterations
Subclonal Architecture

description: Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. Somatic mutations can be measured through massively parallel sequencing, where mutations that are supporting incomplete expansions will appear as subclonal. These mutations can be used as a marker of the existence of the expansion and allow for a window into the clonal and subclonal architecture of the tumour at diagnosis. During my Ph.D. I have developed computational methods to infer intra-tumour hetero- geneity from massively parallel sequencing data and applied these to the 2,778 tumour whole genome sequences in the International Cancer Genome Consortium Pan-Cancer Analysis of Whole Genomes initiative to paint the pan-cancer landscape of intra-tumour heterogeneity. I will first introduce the methods; a method to call somatic copy number alterations (Battenberg) and a method to infer subclones from single nucleotide variants (DPClust). Both are extensively validated on simulated and on real data, and I describe a rigorous quality control procedure. The methods are then applied to a single sample to showcase what can be learned about the life history of a cancer, before introducing additional computational methods for a pan-cancer study of heterogeneity. Finally, I describe the findings. I find that nearly all cancers, for which there is sufficient power, contain at least one subclone (96.7% of 1,801 primary tumours). The subclones contain driver mutations that are under positive selection, and known cancer genes contain subclonal driver mutations in low proportions. 9.5% of tumours contain only subclonal drivers that are clinically actionable, suggesting that heterogeneity could inform treatment choices. Finally, the analysis reveals that activity of smoking and UV-light associated mutational signatures goes down as the tumour evolves, while activity of the APOBEC associated signatures goes up.
description: This thesis was funded by the Wellcome Trust.
Management of Rheumatoid Arthritis: From the Perspective of Complex Network
Creators: name: Shengrong Zou
Publisher: name: figshare
Year: 2018
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Preface 100 years ago, we don’t understand electricity, so we think of the electric eel as an amazing fish. With understanding the electricity, we learn that the power of the eel is produced by muscle discharge. Similarly, if we don’t understand sound, we would not know the magic of bat flying; if we don’t understand magnetic field, we would not know the migration of whale and many other animal. Before the system theory came into being, our understanding of biology is still based on the basis of decomposition and reduction. If we’re stuck in reductionism, many complex autoimmune diseases, such as Rheumatoid arthritis (RA), will be difficult to understand. With the emergence of complex networks in 1989, understanding of biological networks has been enhanced. In this book we present the management strategy of RA from the perspective of complex network. RA is the most common chronic autoimmune joint disease. This book argues that the etiology of RA is mainly caused by chronic stress and stress factors include physical and psychological stress. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this book, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for two year using this strategy, and the management effect is good. This Book argues RA is self- limiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in controlling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis. At next step we hope more researchers to participate in “Network Medicine” study to accumulate more cases, constantly improve the RA network model and analyze parameters characteristic and interaction relationship of RA network model. Only common characteristics network model based on the more RA patients improved in the future, could RA be individualized treated. The research of complex network is still improving, and the research on RA management network will certainly enhance. “The road ahead will be long and our climb will be steep”. I extend my deep appreciation to my wife (one RA patient), for her continuous encouragement and support to write this book. Dr. Shengrong Zou, one Osteoarthritis patient
Implications of the Feldheim Eaton NSF research misconduct case
Creators: name: Bauchwitz, Robert
Publisher: name: figshare
Year: 2018
Subjects: subject: 160599 Policy and Administration not elsewhere classified
subject: FOS: Political science

description: These results raise questions regarding the U.S. research misconduct oversight system ... In particular, what precipitated the retreat of the NSF Director’s Office from the findings of its own OIG, and does this incident have any more general relevance for the handling of research misconduct investigation in the U.S.?
Predictors of necessity for endoscopic balloon dilatation in patients with Crohn’s disease-related small bowel stenosis
Creators: name: Hayashi, Yukie
name: Takabayashi, Kaoru
name: Hosoe, Naoki
name: Kiyohara, Hiroki
name: Kinoshita, Satoshi
name: Nanki, Kosaku
name: Fukuhara, Kayoko
name: Mikami, Yohei
name: Sujino, Tomohisa
name: Mutaguchi, Makoto
name: Kawaguchi, Takaaki
name: Kato, Motohiko
name: Ogata, Haruhiko
name: Kanai, Takanori
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: In patients with Crohn’s disease (CD) and small bowel stenosis, endoscopic balloon dilation (EBD) is considered to be useful in improving stenotic symptoms and avoiding surgery. However, it carries risks such as bleeding and perforation. The aim of this study was to identify the indications for endoscopic intervention in patients with CD and small bowel stenosis. From November 2007 to March 2020, 143 CD patients with small bowel stenosis were enrolled in this study. We identified the factors associated with not requiring endoscopic intervention during long-term follow-up of these patients. Forty of the 143 patients had abdominal symptoms of stenosis and had undergone EBD, whereas the remaining 103 were asymptomatic and had not undergone endoscopic intervention. During long-term follow-up, 95 of those 103 patients never required endoscopic or surgical intervention. Multivariate logistic regression analysis revealed that not consuming an elemental diet (OR 3.18, 95% CI 1.48–6.82; p < .01) and ileocecal valve (ICV) stenosis (OR 0.30, 95% CI 0.11–0.83; p = .02) were independently associated with not requiring EBD. The cumulative emergency hospitalisation-free rate also tended to be higher in patients not consuming an elemental diet or with ICV stenosis. Two factors, namely not consuming an elemental diet and ICV stenosis, predict a long-term intervention-free prognosis in CD patients with small bowel stenosis.Key messagesWhen an endoscopically impassable small bowel stenosis is found in a CD patient, long-term follow-up without endoscopic intervention may be possible if the patient is asymptomatic, is not using an elemental diet, and the stenosis is ICV. When an endoscopically impassable small bowel stenosis is found in a CD patient, long-term follow-up without endoscopic intervention may be possible if the patient is asymptomatic, is not using an elemental diet, and the stenosis is ICV.
Dynamical Formation of Close Binaries During the Pre-main-sequence Phase
Creators: name: Moe, Maxwell
name: Kratter, Kaitlin M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Solar-type binaries with short orbital periods ($P_{\rm close}$ $\equiv$ 1 - 10 days; $a$ $\lesssim$ 0.1 AU) cannot form directly via fragmentation of molecular clouds or protostellar disks, yet their component masses are highly correlated, suggesting interaction during the pre-main-sequence (pre-MS) phase. Moreover, the close binary fraction of pre-MS stars is consistent with that of their MS counterparts in the field ($F_{\rm close}$ = 2.1%). Thus we can infer that some migration mechanism operates during the early pre-MS phase ($τ$ $\lesssim$ 5 Myr) that reshapes the primordial separation distribution. We test the feasibility of this hypothesis by carrying out a population synthesis calculation which accounts for two formation channels: Kozai-Lidov (KL) oscillations and dynamical instability in triple systems. Our models incorporate (1) more realistic initial conditions compared to previous studies, (2) octupole-level effects in the secular evolution, (3) tidal energy dissipation via weak-friction equilibrium tides at small eccentricities and via non-radial dynamical oscillations at large eccentricities, and (4) the larger tidal radius of a pre-MS primary. Given a 15% triple star fraction, we simulate a close binary fraction from KL oscillations alone of $F_{\rm close}$ $\approx$ 0.4% after $τ$ = 5 Myr, which increases to $F_{\rm close}$ $\approx$ 0.8% by $τ$ = 5 Gyr. Dynamical ejections and disruptions of unstable coplanar triples in the disk produce solitary binaries with slightly longer periods $P$ $\approx$ 10 - 100 days. The remaining $\approx$60% of close binaries with outer tertiaries, particularly those in compact coplanar configurations with log $P_{\rm out}$ (days) $\approx$ 2 - 5 ($a_{\rm out}$ $
description: Accepted by ApJ; 23 pages; 8 figures; this version incorporates changes made to address comments by referee
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 1209
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 1209, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 1209, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q15945019
description: Provenance: abbaye Saint-Étienne de Dijon
A note on the SYK model with complex fermions
Creators: name: Bulycheva, Ksenia
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a version of the Sachdev-Ye-Kitaev model with complex fermions. We apply the shadow formalism to find four-point functions in the leading order in $1/N$ and dimensions of operators present in the theory. We also compute the retarded kernel and show that the Lyapunov exponent for the mode corresponding to the $U(1)$ charge is zero.
description: 32 pages
JointDNN: An Efficient Training and Inference Engine for Intelligent Mobile Cloud Computing Services
Creators: name: Eshratifar, Amir Erfan
Publisher: name: figshare
Year: 2018
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology

description: Deep Neural Networks (DNNs) are among the most influential architectures of deep learning algorithms, being deployed in many mobile intelligent applications. End-side services, such as intelligent personal assistants (IPAs), autonomous cars, and smart home services often employ either simple local models or complex remote models on the cloud. Mobile-only and cloud-only computations are currently the status-quo approaches. In this paper, we propose an efficient, adaptive, and practical engine, JointDNN, for collaborative computation between a mobile device and cloud for DNNs in both inference and training phase. JointDNN not only provides an energy and performance efficient method of querying DNNs for the mobile side, but also benefits the cloud server by reducing the amount of its workload and communications compared to the cloud-only approach. Given the DNN architecture, we investigate the efficiency of processing some layers on the mobile device and some layers on the cloud server. We provide optimization formulations at layer granularity for forward and backward propagation in DNNs, which can adapt to mobile battery limitations and cloud server load constraints and quality of service. JointDNN achieves up to 18x and 32x reductions on the latency and mobile energy consumption of querying DNNs compared to the status-quo approaches, respectively.
Blog: Announcing the Winners of the First ORCID Consortia Awards
Creators: name: Meadows, Alice
Publisher: name: ORCID
Year: 2018
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: One of the highlights of our first consortia workshop was the opportunity to recognize the great work that our consortia partners have been doing to promote ORCID adoption in their region. Here we share the awards made to five consortia who have gone above and beyond in their support for ORCID.
Precision measurement of the $β$-asymmetry in spin-polarized $^{37}\mathrm{K}$ decay
Creators: name: Fenker, B.
name: Gorelov, A.
name: Melconian, D.
name: Behr, J. A.
name: Anholm, M.
name: Ashery, D.
name: Behling, R. S.
name: Cohen, I.
name: Craiciu, I.
name: Gwinner, G.
name: McNeil, J.
name: Mehlman, M.
name: Olchanski, K.
name: Shidling, P. D.
name: Smale, S.
name: Warner, C. L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Using TRIUMF's neutral atom trap, TRINAT, for nuclear $β$ decay, we have measured the $β$ asymmetry with respect to the initial nuclear spin in $^{37}\mathrm{K}$ to be $A_β=-0.5707(13)_\mathrm{syst}(13)_\mathrm{stat}(5)_\mathrm{pol}$, a 0.3% measurement. This is the best relative accuracy of any $β$-asymmetry measurement in a nucleus or the neutron, and is in agreement with the standard model prediction $-0.5706(7)$. We compare constraints on physics beyond the standard model with other $β$-decay measurements, and improve the value of $V_\mathrm{ud}$ measured in this mirror nucleus by a factor of 4.
Impact of multimorbidity and polypharmacy on the management of patients with atrial fibrillation: insights from the BALKAN-AF survey
Creators: name: Kozieł, Monika
name: Simovic, Stefan
name: Pavlovic, Nikola
name: Kocijancic, Aleksandar
name: Paparisto, Vilma
name: Music, Ljilja
name: Trendafilova, Elina
name: Dan, Anca Rodica
name: Kusljugic, Zumreta
name: Dan, Gheorghe-Andrei
name: Lip, Gregory Y. H.
name: Potpara, Tatjana S.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: We investigated the impact of multimorbidity and polypharmacy on the management of atrial fibrillation (AF) patients in clinical practice and assessed factors associated with polypharmacy and oral anticoagulation (OAC) use in AF patients with multimorbidity and polypharmacy. A 14-week prospective study of consecutive non-valvular AF patients was performed in seven Balkan countries. Of 2712 consecutive patients, 2263 patients (83.4%) had multimorbidity (AF + ≥2 concomitant diseases) and 1505 patients (55.5%) had polypharmacy. 1416 (52.2%) patients had both multimorbidity and polypharmacy. Overall, 1164 (82.2%) patients received OAC, 200 (14.1%) patients received antiplatelet drugs alone and 52 (3.7%) patients had no antithrombotic therapy (AT). Non-emergency centre and paroxysmal AF were significantly associated with OAC non-use in patients with multimorbidity, whilst age ≥80 years and non-emergency centre were identified to be independent predictors of OAC non-use in patients with polypharmacy. Multimorbidity and polypharmacy were common among AF patients in our study. AT was suboptimal and approximately 18% of multimorbid patients with polypharmacy were not anticoagulated. Pattern of AF and non-emergency centre were associated with OAC non-use in AF patients with multimorbidity, whilst non-emergency centre and age ≥80 years were associated with OAC non-use in AF patients with polypharmacy.Key MessageMultimorbidity and polypharmacy are common among patients with AF.Antithrombotic therapy was suboptimal in AF patients with multimorbidity and polypharmacy.Approximately, 18% of multimorbid patients with polypharmacy were not anticoagulated. Multimorbidity and polypharmacy are common among patients with AF. Antithrombotic therapy was suboptimal in AF patients with multimorbidity and polypharmacy. Approximately, 18% of multimorbid patients with polypharmacy were not anticoagulated.
Association between apnea-hypopnea index and coronary artery calcification: a systematic review and meta-analysis
Creators: name: Hao, Wen
name: Wang, Xiao
name: Fan, Jingyao
name: Zeng, Yaping
name: Ai, Hui
name: Nie, Shaoping
name: Wei, Yongxiang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Hematology

description: The present study aimed to evaluate the association between presence and severity of obstructive sleep apnoea (OSA) and the presence of subclinical coronary artery disease (CAD) as assessed by coronary calcium score. Medline, Cochrane, and Google Scholar databases were searched. The presence of coronary artery calcification (CAC) and CAC score were assessed. Irrespective of the cut-off value of apnoea-hypopnea index (AHI) (5 or 15 events/h), patients in the OSA group had higher rate of CAC presence and mean CAC score than those in the control group. Subgroup analyses of patients monitored with home sleep apnoea testing (HSAT) or in-hospital/laboratory polysomnography showed that the OSA group had higher rate of CAC presence and mean CAC score than the control group, except in the comparison of mean CAC score between AHI ≥5 vs. <5 events/h for patients using HSAT, which was not significant. Pair-wise comparison showed that CAC score may increase with increased OSA severity. In participants without symptomatic coronary disease, the presence of OSA was associated with the presence and extent of CAC. However, potential confounders such as age, gender, and BMI and the diversity of CAC scores may affect the association.
Binary strings of length $n$ with $x$ zeros and longest $k$-runs of zeros
Creators: name: Nej, Monimala
name: Reddy, A. Satyanarayana
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A10, 05A15, 05A19, 11B39

description: In this paper, we study $F_{n}(x,k)$, the number of binary strings of length $n$ containing $x$ zeros and a longest subword of $k$ zeros. A recurrence relation for $F_{n}(x,k)$ is derived. We expressed few known numbers like Fibonacci, triangular, number of binary strings of length $n$ without $r$-runs of ones and number of compositions of $n+1$ with largest summand $k+1$ in terms of $F_{n}(x,k).$ Similar results and applications were obtained for F$_{n}(x,k),$ the number of all palindromic binary strings of length $n$ containing $x$ zeros and longest $k$-runs of zeros.
description: 18 pages
Study of transport coefficients in ultrarelativistic kinetic theory
Creators: name: Ambrus, Victor E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: A spatially-periodic longitudinal wave is considered in relativistic dissipative hydrodynamics. At sufficiently small wave amplitudes, an analytic solution is obtained in the linearised limit of the macroscopic conservation equations within the first- and second-order relativistic hydrodynamics formulations. A kinetic solver is used to obtain the numerical solution of the relativistic Boltzmann equation for massless particles in the Anderson-Witting approximation for the collision term. It is found that, at small values of the Anderson-Witting relaxation time $τ$, the transport coefficients emerging from the relativistic Boltzmann equation agree with those predicted through the Chapman-Enskog procedure, while the relaxation times of the heat flux and shear pressure are equal to $τ$. These claims are further strengthened by considering a moment-type approximation based on orthogonal polynomials under which the Chapman-Enskog results for the transport coefficients are exactly recovered.
description: 34 pages (double column), 15 figures. Version accepted for publication in PRC
Prognostic value of GRACE and CHA2DS2-VASc score among patients with atrial fibrillation undergoing percutaneous coronary intervention
Creators: name: Guo, Tingting
name: Xi, Ziwei
name: Qiu, Hong
name: Wang, Yong
name: Zheng, Jianfeng
name: Dou, Kefei
name: Xu, Bo
name: Qiao, Shubin
name: Yang, Weixian
name: Gao, Runlin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Hematology
subject: Virology

description: The GRACE and CHA2DS2-VASc risk score are developed for risk stratification in patients with acute coronary syndrome and AF, respectively. We aimed to assess the predictive performance of the GRACE score and CHA2DS2-VASc score among patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). Consecutive patients with a diagnosis of AF admitted to our hospital for PCI between January 2016 and December 2018 were included and followed up for at least 1 year. The primary endpoint was a composite of major adverse cardiac events (MACEs) including all-cause mortality, repeat revascularization, myocardial infarction, or ischaemic stroke. A total of 1452 patients were identified. Cox regression demonstrated that the GRACE (HR 1.014, 95% CI 1.008–1.020, p < 0.001) but not the CHA2DS2-VASc score was associated with the risk of MACEs. Both GRACE and CHA2DS2-VASc scores were predictive of all-cause mortality with HR of 1.028 (95% CI 1.020–1.037, p < 0.001) and 1.334 (95% CI 1.107–1.632, p = 0.003). Receiver operating characteristic analyses showed both scores had similar discrimination capacity for all-cause mortality (C-statistic: 0.708 for GRACE vs. 0.661 for CHA2DS2-VASc, p = 0.299). High GRACE score was also significantly associated with increased risk of ischaemic stroke (HR 1.018, 95% CI 1.005–1.031, p = 0.006) and major bleeding (HR 1.012, 95% CI 1.001–1.024, p = 0.039), whereas high CHA2DS2-VASc score was not. High GRACE score but not CHA2DS2-VASc score were both associated with an increased risk of MACEs after PCI in patients with AF. The GRACE and CHA2DS2-VASc scores have similar predictive performance for predicting all-cause mortality.Key messages:In patients with AF undergoing PCI, increasing GRACE but not CHA2DS2-VASc scores was independently associated high risk of MACEs.The GRACE score could also help identify patients at higher risk of stroke and major bleeding.Both GRACE and CHA2DS2-VASc scores showed good ability in the prediction of all-cause mortality. In patients with AF undergoing PCI, increasing GRACE but not CHA2DS2-VASc scores was independently associated high risk of MACEs. The GRACE score could also help identify patients at higher risk of stroke and major bleeding. Both GRACE and CHA2DS2-VASc scores showed good ability in the prediction of all-cause mortality.
Comprehensive meta-analysis of anti-BCMA chimeric antigen receptor T-cell therapy in relapsed or refractory multiple myeloma
Creators: name: Zhang, Lina
name: Shen, Xuxing
name: Yu, Wenjun
name: Li, Jing
name: Zhang, Jue
name: Zhang, Run
name: Li, Jianyong
name: Chen, Lijuan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Chimeric antigen receptor (CAR) T-cell therapy shows impressive results in clinical trials. We conducted a meta-analysis based on the most recent data to systematically describe the efficacy and safety of anti-BCMA CAR T therapy for patients with relapsed or refractory multiple myeloma (R/R MM). PubMed, Embase, Web of Science, Cochrane library, ClinicalTrials.gov, China Biology Medicine disc (CBM disc) and Wanfang Data were searched on 8 November 2020. Registration number of PROSPERO was CRD42020219127. From 763 articles, we identified 22 appropriate studies with 681 patients. The pooled overall response rate (ORR) was 85.2% (95%CI 0.797–0.910), complete response rate (CRR) was 47.0% (95%CI 0.378–0.583), and minimal residual disease (MRD) negativity rate was 97.8% (95%CI 0.935–1.022). The pooled incidence of grade 3–4 cytokine release syndrome was 6.6% (95%CI 0.036–0.096) and neurotoxicity was 2.2% (95%CI 0.006–0.038). The median progression-free survival (PFS) was 14.0 months and median overall survival (OS) was 24.0 months. Subgroup analysis showed dual epitope-binding CAR T cells achieved the best therapy outcomes and humanized CAR T cells had the best safety profile. Patients who were older, heavily pre-treated or received lower dose of CAR T cells had worse ORR. There was no significant difference in ORR, CRR and PFS between patients with and without high-risk cytogenetic features. The PFS and CRR of non-extramedullary disease (EMD) group was superior to those of EMD group. Anti-BCMA CAR T therapy is effective and safe for patients with R/R MM. It can improve the prognosis of patients with high-risk cytogenetic features while the prognosis of patients with EMD remains poor. Moreover, patients are likely to benefit from an earlier use of CAR T therapy and human-derived CAR T cells have obvious advantages based on the existing data.
Fault related frequency anomalies: geometric controls from seismic forward modelling
Creators: name: Oldfield, Simon
name: Paton, Douglas
name: Bramham, Emma
name: Torvela, Taija
Publisher: name: figshare
Year: 2018
Subjects: subject: 40312 Structural Geology
subject: FOS: Earth and related environmental sciences
subject: Geology
subject: 40309 Petroleum and Coal Geology

description: Faulting affects the seismic response in a variety of manners. Geometric attributes such as curvature and coherency greatly assist interpretation of fault networks. Trace attributes such as amplitude and frequency commonly exhibit anomalous responses associated with faults however are less diagnostic.
Using seismic forward modelling we demonstrate that frequency anomalies comparable to those observed in real data may be generated using a simple normal fault geometry. No variation in fluid or solid phase composition or fault-related deformation is required.

Spatial variation of these anomalies across the fault plane indicate that fault response may vary without inferring associated compositional or structural change. This implies that methods seeking to identify uniform fault characteristics to assist interpretation are flawed even in the case of simple faults if juxtaposition is present.

Basic modelling methods demonstrate that the spatial variance is predictable. As such, the response should be considered in attempt to isolate fault-deformation or fault-composition responses. This may form the basis of a tool to advance such observations and refine the fault interpretation process.
Spatially variant uncertainty in the geological interpretation of reflection seismic data
Creators: name: Oldfield, Simon
name: Paton, Douglas A
name: Bramham, Emma K
name: Torvela, Taija
Publisher: name: figshare
Year: 2018
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: 40312 Structural Geology
subject: 40309 Petroleum and Coal Geology

description: Conference abstract: EGU General Assembly 2018
Quantifying uncertainty in seismic interpretation is typically achieved through stochastic modelling. Propagating expected variability in structural geometry through the seismic processing and interpretation workflows considers inherent errors however fails to constrain uncertainty in the interpretation.
Misinterpretation may occur when practitioners make a categorical decision adjusting the assumptions applied during interpretation. Applying different a priori knowledge this may lead the interpreter to apply inappropriate base values during stochastic modelling.
Modelling the seismic reflection response of alternate interpretation cases provides new insight into interpretation uncertainty. Furthermore it provides the initial steps of quantifying interpretation uncertainty.
Understanding the illumination, resolution and detectability of data constrains the variation of interpretation uncertainty in space. Combining knowledge of this spatial variation with basic logic of interpretation provides a means to greatly improve our potential to conceive and consider alternate models.
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00489
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00489, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00489, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Prospective analysis of the port-wine stain patient population in the Netherlands in light of novel treatment modalities
Creators: name: M. Ingmar Van Raath
name: Bambach, Caroline A.
name: Dijksman, Lea M.
name: Wolkerstorfer, Albert
name: Heger, Michal
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 60506 Virology
subject: FOS: Biological sciences

description: Background: Pulsed dye laser is the gold standard for port-wine stain (PWS) treatment. However, pulsed dye lasers achieve suboptimal clinical results in a majority of patients. Patient demand for novel therapies and willingness to participate in clinical studies is currently unknown, yet, imperative for steering R&D activity. The objective of this study was to evaluate these two factors in relation to PWS patient demographics. Methods: A questionnaire was used to assess patient and PWS characteristics, treatment history, efficacy, and satisfaction, stress level, willingness to travel and pay for an effective treatment, participation in clinical studies, and amenability to intravenous drug administration. Descriptive statistics and correlation analysis were performed. Results: Of the respondents (N = 108), 65% would participate in clinical studies and 49% would accept intravenous drugs. For an effective treatment, 58% was prepared to pay over €2,000 and 48% would travel more than 6 h. Travel time was inversely correlated with age, clearance rate, and satisfaction. Facial PWS patients had undergone more treatments, were less satisfied, and less willing to participate in studies or accept intravenous drugs. Stress levels were higher in females. Conclusion: There is considerable demand for new PWS therapies, and a substantial proportion of patients are willing to participate in clinical studies.
Relating out-of-time-order correlations to entanglement via multiple-quantum coherences
Creators: name: Gärttner, Martin
name: Hauke, Philipp
name: Rey, Ana Maria
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Out-of-time-order correlations (OTOCs) characterize the scrambling, or delocalization, of quantum information over all the degrees of freedom of a system and thus have been proposed as a proxy for chaos in quantum systems. Recent experimental progress in measuring OTOCs calls for a more thorough understanding of how these quantities characterize complex quantum systems, most importantly in terms of the buildup of entanglement. Although a connection between OTOCs and entanglement entropy has been derived, the latter only quantifies entanglement in pure systems and is hard to access experimentally. In this work, we formally demonstrate that the multiple-quantum coherence spectra, a specific family of OTOCs well known in NMR, can be used as an entanglement witness and as a direct probe of multiparticle entanglement. Our results open a path to experimentally testing the fascinating idea that entanglement is the underlying glue that links thermodynamics, statistical mechanics, and quantum gravity.
description: 4 pages + references and 8 pages of supplementary materials. v2: as published
Additional file 1 of Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16 regulates the proliferation and EMT of pancreatic cancer
Creators: name: Mao, Yingqing
name: Su, Xian
name: Guo, Qingsong
name: Yao, Xihao
name: Zhao, Qun
name: Guo, Yibing
name: Wang, Yao
name: Li, Xiaohong
name: Lu, Yuhua
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Cancer

description: Supplementary Material 1
F: Panorama Ridge, North Pole Dome South, site 18. Archaean basin margin geology and crustal evolution: an East Pilbara traverse
Creators: name: Nijman, Wouter
name: Kloppenburg, Armelle
name: Vries, Sjoukje T. De
Publisher: name: Geological Society of London
Year: 2018
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary figure f: Panorama Ridge, North Pole Dome South, site 18
Nonmonotonic strain dependence of lattice thermal conductivity in monolayer SiC: a first-principles study
Creators: name: Guo, San-Dong
name: Liu, Jiang-Tao
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: An increasing number of two-dimensional (2D) materials have already been achieved experimentally or predicted theoretically, which have potential applications in nano- and opto-electronics. Various applications for electronic devices are closely related to their thermal transport properties. In this work, the strain dependence of phonon transport in monolayer SiC with a perfect planar hexagonal honeycomb structure is investigated by solving the linearized phonon Boltzmann equation. It is found that room-temperature lattice thermal conductivity ($κ_L$) of monolayer SiC is two orders of magnitude lower than that of graphene. The low $κ_L$ is due to small group velocities and short phonon lifetimes, which can also be explained by polarized covalent bond due to large charge transfer from Si to C atoms. In considered strain range, it is proved that the SiC monolayer is mechanically and dynamically stable. With increased tensile strain, the $κ_L$ of SiC monolayer shows an unusual nonmonotonic up-and-down behavior, which is due to the competition between the change of phonon group velocities and phonon lifetimes of low frequency phonon modes. At low strains ($$8\%) the reduction of group velocities as well as the decrease of the phonon lifetimes are the major mechanism responsible for decreased $κ_L$. Our works further enrich studies on phonon transports of 2D materials with a perfect planar hexagonal honeycomb structure, and motivate farther experimental studies.
description: 8 pages, 14 figures
title: 03_0581
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Approximation of fracture energies with $p$-growth via piecewise affine finite elements
Creators: name: Conti, Sergio
name: Focardi, Matteo
name: Iurlano, Flaviana
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: The modeling of fracture problems within geometrically linear elasticity is often based on the space of generalized functions of bounded deformation $GSBD^p(Ω)$, $p\in(1,\infty)$, their treatment is however hindered by the very low regularity of those functions and by the lack of appropriate density results. We construct here an approximation of $GSBD^p$ functions, for $p\in(1,\infty)$, with functions which are Lipschitz continuous away from a jump set which is a finite union of closed subsets of $C^1$ hypersurfaces. The strains of the approximating functions converge strongly in $L^p$ to the strain of the target, and the area of their jump sets converge to the area of the target. The key idea is to use piecewise affine functions on a suitable grid, which is obtained via the Freudhental partition of a cubic grid.