title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¾ÑÐµÐºÑÐ¸Ð½-ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐµÐ¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð³Ð¸Ð¿Ð¾ÑÐ°Ð»Ð°Ð¼ÑÑÐ° Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð°Ð»ÐºÐ¾Ð³Ð¾Ð»Ð¸Ð·Ð¼Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: The study of the hypothalamic orexin system in patients with alcohol addiction
Creators: name: Ð ÑÐ´ÐµÐ»Ñ, ÐÐ»ÐµÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ð°Ð»ÐºÐ¾Ð³Ð¾Ð»ÑÐ½Ð°Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ
Ð¾ÑÐµÐºÑÐ¸Ð½
Ð¾ÑÐµÐºÑÐ¸Ð½Ð¾Ð²Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð°
Ð³Ð¸Ð¿Ð¾ÑÐ°Ð»Ð°Ð¼ÑÑ
chronic alcohol addiction
orexin
orexin system
hypothalamus

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description: In this investigation a comparative study of the orexinergic system changes in patients suffering from chronic alcohol use disorder and persons without CNS pathology was performed. Assessment of changes in the hypothalamic orexinergic system was performed by quantitive estimation of orexin-containing neurons in the autopsy hypothalamic material in patients with alcohol addiction and people without CNS pathology. An immunohistochemical analysis of the amount of orexin-positive neurons in the structures of the hypothalamus revealed no significant differences between the group of patients with alcohol addiction and the control group. Based on the results of the study, we conclude that it is necessary to consider the orexinergic system in conjunction with other neuromediator systems, such as dopamine, GABAergic and histaminergic systems. Moreover, the under-standing of orexin receptors distribution in the brain structures associated with addiction should help to understand their possible participation in various interneuronal interactions in the development of chronic alcohol use disorder.