The effect of purslane supplementation on blood pressure: a protocol for a systematic review and meta-analysis of randomized control trials.
Creators: name: Pedram Delgarm
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Alternative and Complementary Medicine

description: The effect of purslane supplementation on blood pressure: a protocol for a systematic review and meta-analysis of randomized control trials. Pedram Delgarm, Seyedeh Tayebeh Rahideh Review question What is the effect of purslane supplementation on blood pressure in adults? Search The systematic literature search will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. The systematic search will be conducted by using pre-defined search terms in PubMed, Scopus and Web of sciences to February 2023. Titles and abstracts will be screened according to the pre-defined inclusion and exclusion criteria to identify eligible studies. Full texts will be retrieved and independently assess for eligibility by two review authors. Any disagreements will be resolved by consensus. Reference lists of all potential relevant articles and reviews will be screened to find further potential relevant studies. The systematic search will be restricted to articles published in English. Types of study to be included Randomized controlled trials. Condition or domain being studied Effect of purslane supplementation on blood pressure in adults. Participants/population Inclusion: adults aged &gt;18 years Exclusion: Pregnant and lactating women, children Intervention(s), exposure(s) Purslane supplementation Comparator(s)/control Placebo Main outcome(s) Changes in the systolic and diastolic blood pressure Additional outcome(s) None. Measures of effect Mean difference with 95% confidence interval. Data extraction Two authors independently and in duplicate will review the full text of potential eligible articles for eligibility. From studies that will be considered eligible, two independent reviewers will extract the following data: author and year; population location, study design and duration, characteristics of the population (% female, mean age +/- SD, baseline BMI), total sample size, intervention characteristics (type and dose of purslane supplementation), comparison group, outcome measures and main results for the outcomes included. Risk of bias (quality) assessment Two reviewers independently and in duplicate will perform the quality assessment. The evaluation of randomized controlled trials will be done using the Cochrane risk of bias tool. Strategy for data synthesis We will perform a random-effect meta-analysis. In cases where the reported data will not include mean and SD, we will utilize appropriate formulae to calculate mean and SD from the available statistical data The Cochran Q and I2 statistics will be used to test for heterogeneity. Publication bias will be examined by visual inspection of funnel plots when at least 10 primary studies were available. To evaluate the potential source and effect of bias, a sensitivity analysis will carry out. Statistical analyses will be conducted using STATA version 17.0. A two-tailed P value of less than 0.05 will be considered significant. Analysis of subgroups or subsets We will perform a series of subgroup analyses based on health status, type of intervention, and duration of intervention. Type and method of review Meta-analysis of randomized controlled trials Anticipated or actual start date 30 May 2023 Anticipated completion date 30 June 2023 Funding sources/sponsors None. Conflicts of interest None Language English Country Iran