title: ÐÐ°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð¿ÑÐ¾Ð½Ð¸ÑÐ°ÐµÐ¼Ð¾ÑÑÐ¸ Ð¼Ð¾Ð´ÐµÐ»ÑÐ½ÑÑ Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÑ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½ Ð¾Ñ ÑÐ¾ÑÑÐ°Ð²Ð° Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÑ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð² Ð¿Ð¾Ð»Ð¸ÐµÐ½Ð¾Ð²ÑÑ Ð°Ð½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ¾Ð² Ñ ÑÐ»Ð°Ð²Ð°Ð½Ð¾Ð¸Ð´Ð°Ð¼Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The dependence of the permeability of model lipid membranes on the composition of liposomal complexes of polyene antibiotics with flavonoids
Creators: name: ÐÐ°ÑÐ²ÐµÐµÐ²Ð°, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð¼Ð¾Ð´ÐµÐ»ÑÐ½ÑÐµ Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÐµ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ñ
Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ñ
Ð¿Ð¾Ð»Ð¸ÐµÐ½Ð¾Ð²ÑÐµ Ð°Ð½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ¸
Ð°Ð¼ÑÐ¾ÑÐµÑÐ¸ÑÐ¸Ð½ Ð
ÑÐ»Ð°Ð²Ð°Ð½Ð¾Ð¸Ð´Ñ
model lipid membranes
liposomes
polyene antibiotics
amphotericin B
flavanoids

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description: The polyene antibiotics are natural chemical compounds produced by microorganisms of the Streptomyces. Polyene antibiotics are the most effective drugs for the treatment of fungal infections due to their powerful fungicidal activity, wide spectrum of action and low frequency of resistance in fungi. Lipid forms of polyene antibiotics are successfully used to reduce their toxicity, while maintaining their antifungal effectiveness. However, the problem of toxicity has not been resolved. The aim of the work is to study the dependence of the permeability of model lipid membranes on the composition of liposomal complexes of polyene antibiotics with flavanoids. The electrophysiological measurements of the currents induced by the introduction of the liposomal complexes of various compositions and the method the spectrofluorimetric method for measuring the leafage of the fluorescent dye calcein from vesicles have been used. It was found that the replacement in the liposomal form of amphotericin B of cholesterol on the 7-dehydrocholesterol or desmasterol demonstrated their intermediate affinity for amphotericin B between cholesterol and ergosterol, that may indicated on their lower toxicity. The introduction of the flavanoids into the liposomal complexes of the polyene antibiotics leads to an increase in the effectiveness of the developed drug. Thus, the developed complexes, including phospholipids, sterols, and flavanoids, can be considered as improved forms of amphotericin B.