cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Environmental Scan of Repositories of Clinical Research Data: How Far Have We Got With Public Disclosure of Trial Data?
Creators: name: Krleza-Jeric, Karmela
name: Hrynaszkiewicz, Iain
Publisher: name: figshare
Year: 2016
Subjects: subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 140208 Health Economics
subject: FOS: Economics and business

description: Clinical research data sharing is expected to decrease the burden on research subjects, enabling more efficient and reliable research; promote innovations and entrepreneurship; and facilitate knowledge synthesis, discovery and translation that could ultimately inform clinical decision making. Data repositories are key elements for achieving broad data sharing but in clinical research there is no repository for raw data which covers a variety of medical disciplines. Furthermore, to our knowledge there is no wide agreement on the standards, best practices and essential features of clinical data repositories. The environmental scan aims to produce comprehensive information on the features and practices of data repositories with interests in clinical data disclosure.
In Memoriam: Dr O. G. S. Crawford, C.B.E., F.S.A.; Hon. Marjorie Cross and Mr Thomas Hay, M.A., B.Sc.
Creators: name: Anon,
Publisher: name: Archaeology Data Service
Year: 2017

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 57, 203-204
Game Bilangan Novita Wandasari
Creators: name: Wandasari, Novita
Publisher: name: figshare
Year: 2016
Subjects: subject: Computer Engineering
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology
subject: 80103 Computer Graphics
subject: FOS: Computer and information sciences

description: Merupakan game untuk mempelajari bilangan di kelas 7 SMP
Additional file 3 of Correlation between quality and geographical origins of Leonuri Herba revealed by the qualitative fingerprint profiling and quantitative determination of chemical components
Creators: name: Lam, Kelly Yinching
name: Wang, Yinghao
name: Lam, Tszking
name: Ku, Chuenfai
name: Yeung, Wingping
name: Zhao, Zhongzhen
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 3: Table S2. The RSD values of precisions, reproducibility, stability and recovery for the eight compounds.
Effect of O-methylated and glucuronosylated flavonoids from Tamarix gallica on α-glucosidase inhibitory activity: structure–activity relationship and synergistic potential
Creators: name: Hmidene, Asma Ben
name: Abderrazak Smaoui
name: Chedly Abdelly
name: Isoda, Hiroko
name: Shigemori, Hideyuki
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: O-Methylated and glucuronosylated flavonoids were isolated from Tamarix gallica as α-glucosidase inhibitors. Structure–activity relationship of these flavonoids suggests that catechol moiety and glucuronic acid at C-3 are factors in the increase in α-glucosidase inhibitory activity. Furthermore, rhamnetin, tamarixetin, rhamnazin, KGlcA, KGlcA-Me, QGlcA, and QGlcA-Me exhibit synergistic potential when applied with a very low concentration of acarbose to α-glucosidase from rat intestine.
Georg Schmorl Prize of the German Spine Society (DWG) 2020: new biomechanical in vitro test method to determine subsidence risk of vertebral body replacements
Creators: name: Zengerle, Laura
name: Fleege, Christoph
name: Di Pauli Von Treuheim, Theodor
name: Vogele, Daniel
name: Rauschmann, Michael
name: Wilke, Hans-Joachim
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Thoracolumbar spine
subject: Test method
subject: In vitro
subject: Physiological activities
subject: Vertebral body replacements
subject: Sintering
subject: DDC 610 / Medicine & health

description: Abstract Purpose Prevention of implant subsidence in osteoporotic (thoraco)lumbar spines is still a major challenge in spinal surgery. In this study, a new biomechanical in vitro test method was developed to simulate patient activities in order to determine the subsidence risk of vertebral body replacements during physiologic loading conditions. Methods The study included 12 (thoraco)lumbar (T11-L1, L2-L4) human specimens. After dorsal stabilisation and corpectomy, vertebral body replacements (VBR) with (a) round centrally located and (b) lateral end pieces with apophyseal support were implanted, equally distributed regarding segment, sex, mean BMD ((a) 64.2 mgCaHA/cm3, (b) 66.7 mgCaHA/cm3) and age ((a) 78 years, (b) 73.5 years). The specimens were then subjected to everyday activities (climbing stairs, tying shoes, lifting 20 kg) simulated by a custom-made dynamic loading simulator combining corresponding axial loads with flexion–extension and lateral bending movements. They were applied in oscillating waves at 0.5 Hz and raised every 100 cycles phase-shifted to each other by 50 N or 0.25°, respectively. The range of motion (ROM) of the specimens was determined in all three motion planes under pure moments of 3.75 Nm prior to and after implantation as well as subsequently following activities. Simultaneously, subsidence depth was quantified from fluoroscope films. A mixed model (significance level: 0.05) was established to relate subsidence risk to implant geometries and patients’ activities. Results With this new test method, simulating everyday activities provoked clinically relevant subsidence schemes. Generally, severe everyday activities caused deeper subsidence which resulted in increased ROM. Subsidence of lateral end pieces was remarkably less pronounced which was accompanied by a smaller ROM in flexion–extension and higher motion possibilities in axial rotation (p = 0.05). Conclusion In this study, a new biomechanical test method was developed that simulates physiologic activities to examine implant subsidence. It appears that the highest risk of subsidence occurs most when lifting heavy weights, and into the ventral part of the caudal vertebra. The results indicate that lateral end pieces may better prevent from implant subsidence because of the additional cortical support. Generally, patients that are treated with a VBR should avoid activities that create high loading on the spine.
The evolution of thecideide microstructures and textures: traced from Triassic to Holocene
Creators: name: Simonet Roda, Maria
name: Griesshaber, Erika
name: Angiolini, Lucia
name: Harper, David A.T.
name: Jansen, Ulrich
name: Bitner, Maria Aleksandra
name: Henkel, Daniela
name: Manzanero, Eloy
name: Müller, Tamás
name: Tomašových, Adam
name: Eisenhauer, Anton
name: Ziegler, Andreas
name: Schmahl, Wolfgang W.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: calcite fibre
subject: EBSD
subject: shell microstructure evolution
subject: thecideides
subject: DDC 590 / Animals (Zoology)
subject: Brachiopoda
subject: Calcite crystals
subject: Armfüßer
subject: Elektronenrückstreubeugung

description: Thecideide brachiopods are an anomalous group of invertebrates. In this study, we discuss the evolution of thecideide brachiopods from the Triassic to the Holocene and base our results and conclusions on microstructure and texture measurements gained from electron backscatter diffraction (EBSD). In fossil and Recent thecideide shells, we observe the following mineral units: (1) nanometric to small granules; (2) acicles; (3) fibres; (4) polygonal crystals; and (5) large roundish crystals. We trace for thecideide shells the change of mineral unit characteristics such as morphology, size, orientation, arrangement and distribution pattern. Triassic thecideide shells contain extensive sections formed of fibres interspersed with large, roundish crystals. Upper Cretaceous to Pleistocene thecideide hard tissues consist of a matrix of minute to small grains reinforced by acicles and small polygonal crystals. Recent thecideide species form their shell of mineral units that show a wide range of shapes, sizes and arrangements. We find from Late Triassic to Recent a gradual decrease in mineral unit size, regularity of mineral unit morphology and orientation and the degree of calcite co‐orientation. While crystallite co‐orientation is the highest for fibrous microstructures, it is strikingly low for taxa that form their shell out of nanogranular to acicular mineral units. Our results indicate that Upper Jurassic species represent transitional forms between ancient taxa with fibrous shells and Recent forms that construct their shells of acicles and granules. We attribute the observed changes in microstructure and texture to be an adaptation to a different habitat and lifestyle associated with cementation to hard substrates.
A multicenter prospective, randomized, placebo-controlled phase II/III trial for preemptive acute graft-versus-host disease therapy
Creators: name: Weissinger, Eva M.
name: Metzger, Jochen
name: Schleuning, Michael
name: Schmid, Christoph
name: Messinger, Diethelm
name: Beutel, Gernot
name: Wagner-Drouet, Eva-Maria
name: Schetelig, Johannes
name: Baurmann, Herrad
name: Rank, Andreas
name: Stolzl, Friedrich
name: Schäfer-Eckart, Kerstin
name: Westphal, Karin
name: Bethge, Wolfgang
name: Von Harsdorf, S.
name: Bunjes, Donald W.
name: Heidenreich, Daniela
name: Klein, Stefan
name: Holler, Ernst
name: Kreipe, Hans H.
name: Jonigk, Danny
name: Türüchanow, Irina
name: Raad, Julia
name: Papkalla, Armin
name: Von Der Leyen, Heiko
name: Hambach, Lothar
name: Hamwi, Iyas
name: Ehrlich, Steve
name: Krauter, Jurgen
name: Stadler, Michael
name: Ganser, Arnold
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Clinical trials
subject: Translational research
subject: DDC 610 / Medicine & health

description: Abstract Acute graft-versus-host disease (aGvHD) contributes to about 50% of transplant-related mortality (non-relapse mortality) after allogeneic hematopoietic stem cell transplantation (HSCT). Here the predictive value of a urinary proteomic profile (aGvHD_MS17) was tested together with preemptive prednisolone therapy. Two-hundred and fifty-nine of 267 patients were eligible for analysis. Ninety-two patients were randomized upon aGvHD_MS17 classification factor above 0.1 to receive either prednisolone (2–2.5 mg/kg, N = 44) or placebo (N = 47; N = 1 randomization failure) for 5 days followed by tapering. The remaining 167 patients formed the observation group. The primary endpoint of the randomized trial was incidence of aGvHD grade II between randomization and day +100 post HSCT. Analysis of the short-term preemptive prednisolone therapy in the randomized patients showed no significant difference in incidence or severity of acute GvHD (HR: 1.69, 95% CI: 0.66–4.32, P = 0.27). Prednisolone as preemptive treatment did not lead to an increase in relapse (20.2% in the placebo and 14.0% in the prednisolone group (P = 0.46)). The frequency of adverse events was slightly higher in the placebo group (64.4% versus 50%, respectively). Taken together, the results of the Pre-GvHD trial demonstrated the feasibility and safety of preemptive prednisolone treatment in the randomized patients.
Potential-dependent Pt(111)/water interface : tackling the challenge of a consistent treatment of electrochemical interfaces
Creators: name: Braunwarth, Laura
name: Jung, Christoph
name: Jacob, Timo
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Electrochemical Interface
subject: Force Field Simulations
subject: DDC 540 / Chemistry & allied sciences
subject: Platinum
subject: Water
subject: Modeling
subject: Platin
subject: Wasser

description: The interface between an electrode and an electrolyte is where electrochemical processes take place for countless technologically important applications. Despite its high relevance and intense efforts to elucidate it, a description of the interfacial structure and, in particular, the dynamics of the electric double layer at the atomic level is still lacking. Here we present reactive force-field molecular dynamics simulations of electrified Pt(111)/water interfaces, shedding light on the orientation of water molecules in the vicinity of the Pt(111) surface, taking into account the influence of potential, adsorbates, and ions simultaneously. We obtain a shift in the preferred orientation of water in the surface oxidation potential region, which breaks with the previously proclaimed strict correlation to the free charge density. Moreover, the characterization is complemented by course of the entropy and the intermolecular ordering in the interfacial region complements the characterization. Our work contributes to the ongoing process of understanding electric double layers and, in particular, the structure of the electrified Pt(111)/water interface, and aims to provide insights into the electrochemical processes occurring there.
Guiding the evolution of product-line configurations
Creators: name: Nieke, Michael
name: Sampaio, Gabriela
name: Thüm, Thomas
name: Seidl, Christoph
name: Teixeira, Leopoldo
name: Schaefer, Ina
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Product-line evolution
subject: Guided feature configuration evolution
subject: Product behavior preservation
subject: DDC 000 / Computer science, information & general works
subject: Product lines
subject: Produktlinie

description: Abstract A product line is an approach for systematically managing configuration options of customizable systems, usually by means of features. Products are generated for configurations consisting of selected features. Product-line evolution can lead to unintended changes to product behavior. We illustrate that updating configurations after product-line evolution requires decisions of both, domain engineers responsible for product-line evolution as well as application engineers responsible for configurations. The challenge is that domain and application engineers might not be able to interact with each other. We propose a formal foundation and a methodology that enables domain engineers to guide application engineers through configuration evolution by sharing knowledge on product-line evolution and by defining automatic update operations for configurations. As an effect, we enable knowledge transfer between those engineers without the need for interactions. We evaluate our methodology on four large-scale industrial product lines. The results of the qualitative evaluation indicate that our method is flexible enough for real-world product-line evolution. The quantitative evaluation indicates that we detect product behavior changes for up to 55.3%\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$55.3\%$$\end{document} of the configurations which would not have been detected using existing methods.
Dorcus tianlongi Wang & Zhou 2019
Creators: name: Qi, Zhi-Hao
name: Zhan, Zhi-Hong
name: Su, Rong-Xiang
name: Ding, Bi
name: Liang, Guang-Hong
name: Song, Hai- Tian
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lucanidae
Dorcus
Dorcus tianlongi

description: Dorcus tianlongi Wang & Zhou, 2019
Chinese common name: 天±大*
Figs. 1C–D; 2B; 4C–D; 5I–L; 6C; 7I–L
Dorcus tianlongi Wang & Zhou, 2019: 576 (type locality: China, Guizhou, Tongren City, Jiangkou County, Fanjingshan; holotype in MYNU); Yi 2023: 62 (as Serrognathus).
Material examined. CHINA: 1♂ (CZHZ), Guizhou Province, Tongren City, Jiangkou County [Ĵ口县], Fanjingshan National Natural Reserve [KḀƜ国ẍãnIJ保ae区], Huixiangping [回ẽ坪], alt. 1750 m, 15.VII.2019, Zi-Hao Yang leg.; 1♂ (CXTZ), Guizhou Province, Bijie City, Hezhang County [ĕâ县], Ewaishan [俄ēƜ], alt. 2188 m, 4.VII.2024, local collector leg.
Distribution. China (Guizhou).
description: Published as part of Qi, Zhi-Hao, Zhan, Zhi-Hong, Su, Rong-Xiang, Ding, Bi, Liang, Guang-Hong & Song, Hai- Tian, 2025, Dorcus liyuani Qi & Zhan, a new stag beetle from Gansu, China (Coleoptera: Lucanidae: Lucaninae), pp. 249-262 in Zootaxa 5609 (2) on page 261, DOI: 10.11646/zootaxa.5609.2.6, http://zenodo.org/record/15215214
An experimental test of the Mocikat-Herwig theory of local turbulent heat transfer measurements on cold objects
Creators: name: Kapitz, Marek
name: Wiesche, Stefan Aus Der
name: Kadic, Samir
name: Strehle, Steffen
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Engineering Thermodynamics, Heat and Mass Transfer
subject: Industrial Chemistry/Chemical Engineering
subject: DDC 530 / Physics
subject: DDC 620 / Engineering & allied operations
subject: Chemistry, Technical
subject: Thermodynamics
subject: Technische Chemie
subject: Thermodynamik

description: Abstract Experimental results are presented of a test of the theory of local turbulent heat transfer measurements proposed by Mocikat and Herwig in 2007. A miniaturized multi-layer heat transfer sensor was developed and employed in this study. The new heat transfer sensor was designed to work in air and liquids, and this capability enabled the simultaneous investigation of different Prandtl numbers. Two basic configurations, namely the flow past a blunt plate and the flow past an inclined square cylinder, were investigated in test sections of wind and water tunnels. Convective heat transfer coefficients were obtained through conventional testing (i.e., employing thoroughly heated test objects) and using the new miniaturized sensor approach (i.e., utilizing cold test objects without heating). The main prediction of the Mocikat-Herwig theory that a specific thermal adjustment coefficient of the employed actual miniaturized heat transfer sensor should exist in the fully turbulent flow regime was proven for developed two-dimensional flow. The observed effect of the Prandtl number on this coefficient was in good agreement with the prediction of the asymptotic expansion method. The square cylinder results indicated the inherent limits of the local turbulent heat transfer measurement approach, as suggested by Mocikat and Herwig.
Additional file 1 of A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)
Creators: name: Malchair, Pierre
name: Otero, Aurema
name: Giol, Jordi
name: Solanich, Xavier
name: Carnaval, Thiago
name: Fernández-Nistal, Alonso
name: Sánchez-Gabriel, Ana
name: Montoto, Carmen
name: Lleonart, Ramon
name: Videla, Sebastián
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1. Consent form
Additional file 1 of Repair-related molecular changes during recovery phase of ischemic stroke in female rats
Creators: name: Mostajeran, Maryam
name: Edvinsson, Lars
name: Ahnstedt, Hilda
name: Arkelius, Kajsa
name: Ansar, Saema
Publisher: name: figshare
Year: 2022
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Neuroscience
Developmental Biology

description: Additional file 1: Checklist S1. The ARRIVE guidelines 2.0: author checklist.
Additional file 2 of Repair-related molecular changes during recovery phase of ischemic stroke in female rats
Creators: name: Mostajeran, Maryam
name: Edvinsson, Lars
name: Ahnstedt, Hilda
name: Arkelius, Kajsa
name: Ansar, Saema
Publisher: name: figshare
Year: 2022
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Neuroscience
Developmental Biology

description: Additional file 2: Figure S1. Raw images for Western blot membranes corresponding to Fig. 3A, B in the manuscript. 2A: phosphorylated ERK1/2, total ERK1/2 and β-actin corresponding to Fig. 3A in the manuscript. Fig. 3C: phosphorylated Akt, total Akt, and β-actin corresponding to Fig. 3A in the manuscript. In all peri-infarct vs. contralateral samples (left columns) the lanes labelled with number 1–5 are contralateral samples and lanes labelled number 6–10 are their respective peri-infarct samples. The lanes marked with X were test samples used for the accuracy of the experiment and were not included for statistical analysis; therefore, they were omitted in final figures. In all contralateral versus ischemic core samples (right columns), the lanes labelled number 1–7 are contralateral samples and the lanes labelled number 8–14 are their respective ischemic core samples. Arrows show the band for the protein of interest according to molecular weight. The other bands are nonspecific which could be due to the many different cell types in brain tissue. Molecular weight marker was loaded in all experiments. M molecular marker.
Long‐term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project
Creators: name: Nagel, Gabriele
name: Chen, Jie
name: Jaensch, Andrea
name: Skodda, Lea
name: Rodopoulou, Sophia
name: Strak, Maciej
name: De Hoogh, Kees
name: Andersen, Zorana J.
name: Bellander, Tom
name: Brandt, Jørgen
name: Fecht, Daniela
name: Forastiere, Francesco
name: Gulliver, John
name: Hertel, Ole
name: Hoffmann, Barbara
name: Hvidtfeldt, Ulla Arthur
name: Katsouyanni, Klea
name: Ketzel, Matthias
name: Leander, Karin
name: Magnusson, Patrik K. E.
name: Pershagen, Göran
name: Rizzuto, Debora
name: Samoli, Evangelia
name: Severi, Gianluca
name: Stafoggia, Massimo
name: Tjønneland, Anne
name: Vermeulen, Roel C. H.
name: Wolf, Kathrin
name: Zitt, Emanuel
name: Brunekreef, Bert
name: Hoek, Gerard
name: Raaschou‐Nielsen, Ole
name: Weinmayr, Gudrun
Publisher: name: Universität Ulm
Year: 2024
Subjects: subject: Air pollution
subject: Gastric cancer
subject: Nitrogen dioxide
subject: Ozone
subject: Particular matter
subject: UADT
subject: DDC 610 / Medicine & health

description: Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone in the warm season (O3w) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM2.5, NO2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00–1.33) per 5 μg/m3 increase in PM2.5, 1.19 (1.08–1.30) per 10 μg/m3 increase in NO2, 1.14 (1.04–1.26) per 0.5 × 10−5 m−1 increase in BC and 0.81 (0.72–0.92) per 10 μg/m3 increase in O3w. We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM2.5, NO2 and BC increased incidence of UADT cancer was observed.
Effects of dysphoria and induced negative mood on the processes underlying hindsight bias
Creators: name: Groß, Julia
name: Bayen, Ute J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Hindsight bias is the tendency to overestimate one’s prior knowledge of facts or events once the actual facts or events are known. Several theoretical frameworks suggest that affective states might influence hindsight bias. Nondysphoric participants (n = 123, BDI ≤ 13) in negative or neutral mood, and dysphoric participants (n = 19, BDI > 13) generated and recalled answers to difficult knowledge questions. All groups showed hindsight bias, that is, their recalled estimates were closer to the correct answer when this answer was shown at recall. Multinomial modelling revealed, however, that under dysphoria and induced negative mood different processes contributed to hindsight bias. Dysphoria, but not induced negative mood, was associated with a stronger reconstruction bias, compared with neutral mood. A recollection bias appeared in neutral, but neither in induced negative nor dysphoric mood. These findings highlight differences between the cognitive consequences of dysphoria and induced negative mood.
Valence energy correction for electron reactive force field
Creators: name: Bertolini, Samuel
name: Jacob, Timo
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: bond cleavage
subject: eReaxFF
subject: DDC 540 / Chemistry & allied sciences
subject: Scission (Chemistry)
subject: Charge transfer
subject: Electrons
subject: Molecular dynamics
subject: Water
subject: Ladungstransfer
subject: Elektron
subject: Molekularbewegung

description: Abstract Reactive force fields (ReaxFF) are a classical method to describe material properties based on a bond‐order formalism, that allows bond dissociation and consequently investigations of reactive systems. Semiclassical treatment of electrons was introduced within ReaxFF simulations, better known as electron reactive force fields (eReaxFF), to explicitly treat electrons as spherical Gaussian waves. In the original version of eReaxFF, the electrons and electron–holes can lead to changes in both the bond energy and the Coulomb energy of the system. In the present study, the method was modified to allow an electron to modify the valence energy, therefore, permitting that the electron's presence modifies the three‐body interactions, affecting the angle among three atoms. When a reaction path involving electron transfer is more sensitive to the geometric configuration of the molecules, corrections in the angular structure in the presence of electrons become more relevant; in this case, bond dissociation may not be enough to describe a reaction path. Consequently, the application of the extended eReaxFF method developed in this work should provide an improved description of a reaction path. As a first demonstration this semiclassical force field was parametrized for hydrogen and oxygen interactions, including water and water's ions. With the modified methodology both the overall accuracy of the force field but also the description of the angles within the molecules in presence of electrons could be improved.
description: image
Deliverable 3-6 Green My Place Game Design core document
Creators: name: Cowley, Benjamin
Publisher: name: figshare
Year: 2016
Subjects: subject: 160703 Social Program Evaluation
subject: FOS: Sociology
subject: 170110 Psychological Methodology, Design and Analysis
subject: FOS: Psychology

description: D3.6 is the Green My Place design document. It is a great example of HOW NOT TO WRITE A DESIGN DOC! It is way too long, filled with text, and was developed over several iterations so that it rambles and is hard to follow, not having been written all at once. Its main function was to satisfy the project management, who liked long documents.
Dorcus liyingbingi Huang & Chen 2013
Creators: name: Qi, Zhi-Hao
name: Zhan, Zhi-Hong
name: Su, Rong-Xiang
name: Ding, Bi
name: Liang, Guang-Hong
name: Song, Hai- Tian
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lucanidae
Dorcus
Dorcus liyingbingi

description: Dorcus liyingbingi Huang & Chen, 2013
Chinese common name: ṃĸ大*
Figs. 1E–F; 2C–D; 4E–F; 5M–P; 6D; 7M–P
Dorcus liyingbingi Huang & Chen, 2013: 467 (type locality: China, Yunan, Nujiang, Gongshan County; holotype in ACGU); Yi 2023: 61 (as Serrognathus).
Material examined. CHINA: 2♂♂, 1♀ (all three paratypes, CZHZ) Yunnan Province, Nujiang Lisu Autonomous Prefecture, Gongshan County [ÑƜ县], VII.2011, Ying-Bing Li leg.; 1♂ (CZHQ), Yunnan Province, Nujiang Lisu Autonomous Prefecture, Gongshan County [ÑƜ县], alt. 2400–2600 m, X.2022, Bai-Jun Li leg.
Distribution. China (Yunnan).
description: Published as part of Qi, Zhi-Hao, Zhan, Zhi-Hong, Su, Rong-Xiang, Ding, Bi, Liang, Guang-Hong & Song, Hai- Tian, 2025, Dorcus liyuani Qi & Zhan, a new stag beetle from Gansu, China (Coleoptera: Lucanidae: Lucaninae), pp. 249-262 in Zootaxa 5609 (2) on page 261, DOI: 10.11646/zootaxa.5609.2.6, http://zenodo.org/record/15215214
BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana
Creators: name: Hong, Zheng-Hui
name: Qing, Tao
name: Schubert, Daniel
name: Kleinmanns, Julia Anna
name: Liu, Jian-Xiang
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: BLISTER-regulated
subject: ER stress modulator IRE1A
subject: Arabidopsis thaliana
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The unfolded protein response (UPR) is required for protein homeostasis in the endoplasmic reticulum (ER) when plants are challenged by adverse environmental conditions. Inositol-requiring enzyme 1 (IRE1), the bifunctional protein kinase / ribonuclease, is an important UPR regulator in plants mediating cytoplasmic splicing of the mRNA encoding the transcription factor bZIP60. This activates the UPR signaling pathway and regulates canonical UPR genes. However, how the protein activity of IRE1 is controlled during plant growth and development is largely unknown. In the present study, we demonstrate that the nuclear and Golgi-localized protein BLISTER (BLI) negatively controls the activity of IRE1A/IRE1B under normal growth condition in Arabidopsis. Loss-of-function mutation of BLI results in chronic up-regulation of a set of both canonical UPR genes and non-canonical UPR downstream genes, leading to cell death and growth retardation. Genetic analysis indicates that BLI-regulated vegetative growth phenotype is dependent on IRE1A/IRE1B but not their canonical splicing target bZIP60. Genetic complementation with mutation analysis suggests that the D570/K572 residues in the ATP-binding pocket and N780 residue in the RNase domain of IRE1A are required for the activation of canonical UPR gene expression, in contrast, the D570/K572 residues and D590 residue in the protein kinase domain of IRE1A are important for the induction of non-canonical UPR downstream genes in the BLI mutant background, which correlates with the shoot growth phenotype. Hence, our results reveal the important role of IRE1A in plant growth and development, and BLI negatively controls IRE1A’s function under normal growth condition in plants.
title: OFROM: interview avec unine15a92d
Creators: name: Delafontaine, François
name: Widmer, Aline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.d86625fi.v2#19ccf58216cb303942204d4cfe03f943e78286d5
Deliverable 5-1 Green My Place Game Architecture
Creators: name: Cowley, Benjamin
Publisher: name: figshare
Year: 2016
Subjects: subject: 160703 Social Program Evaluation
subject: FOS: Sociology

description: D5.1 is written to allow an engineer unfamiliar with the project to pick up the fundamentals of the system without having to learn by trial and error. Since the source code is no longer available, this is included merely for reference.
Exploring the foundations of the physical universe with space tests of the equivalence principle
Creators: name: Battelier, Baptiste
name: Bergé, Joël
name: Bertoldi, Andrea
name: Blanchet, Luc
name: Bongs, Kai
name: Bouyer, Philippe
name: Braxmaier, Claus
name: Calonico, Davide
name: Fayet, Pierre
name: Gaaloul, Naceur
name: Guerlin, Christine
name: Hees, Aurélien
name: Jetzer, Philippe
name: Lämmerzahl, Claus
name: Lecomte, Steve
name: Le Poncin-Lafitte, Christophe
name: Loriani, Sina
name: Métris, Gilles
name: Nofrarias, Miquel
name: Rasel, Ernst
name: Reynaud, Serge
name: Rodrigues, Manuel
name: Rothacher, Markus
name: Roura, Albert
name: Salomon, Christophe
name: Schiller, Stephan
name: Schleich, Wolfgang P.
name: Schubert, Christian
name: Sopuerta, Carlos F.
name: Sorrentino, Fiodor
name: Sumner, Timothy J.
name: Tino, Guglielmo M.
name: Tuckey, Philip
name: Klitzing, Wolf Von
name: Wörner, Lisa
name: Wolf, Peter
name: Zelan, Martin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Quantum technologies
subject: Electrostatic accelerometers
subject: PRECISION GRAVITY TESTS
subject: GRAVITATIONAL REDSHIFT
subject: COSMOLOGICAL CONSEQUENCES
subject: CONSTANT
subject: FORCES
subject: UNIFICATION
subject: SENSITIVITY
subject: DDC 530 / Physics
subject: Bose-Einstein condensation
subject: Dark energy (Astronomy)
subject: Equivalence principle (Physics)
subject: Äquivalenzprinzip (Physik)
subject: Bose-Einstein-Kondensation
subject: Dunkle Energie
subject: Atom
subject: Sensibilität

description: Abstract We present the scientific motivation for future space tests of the equivalence principle, and in particular the universality of free fall, at the 10− 17 level or better. Two possible mission scenarios, one based on quantum technologies, the other on electrostatic accelerometers, that could reach that goal are briefly discussed. This publication is a White Paper written in the context of the Voyage 2050 ESA Call for White Papers.
Bee boles and related structures in Furness and Cartmel.
Creators: name: Green, Eric
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 231-238
description: Records forty new sites, identified after the publication of an earlier paper (see 92/974), and now registered with the International Bee Research Association (IBRA). An appendix provides a list of sites (237--8).
Recent archaeological work on the Holm Cultram sea dyke, Skinburness, Cumbria.
Creators: name: Fletcher, Mark
name: Miller, Ian
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 203-216
description: Reports archaeological survey and recording of this apparently late fifteenth- to early sixteenth-century earthwork, before reconstruction work on the sea defences. Although possibly predominantly a late nineteenth- to early twentieth-century reconstruction, a complex of lateral timbers at the northern end may suggest an earlier, medieval, phase.
Additional file 4 of Repair-related molecular changes during recovery phase of ischemic stroke in female rats
Creators: name: Mostajeran, Maryam
name: Edvinsson, Lars
name: Ahnstedt, Hilda
name: Arkelius, Kajsa
name: Ansar, Saema
Publisher: name: figshare
Year: 2022
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Neuroscience
Developmental Biology

description: Additional file 4: Figure S3. Raw images for Western blot membranes corresponding to Fig. 4C in the manuscript. 3C: Tie-2, IL-10, TGF- β and β-actin corresponding to Fig. 4C in the manuscript. In all contralateral samples versus peri-infarct (left columns) the lanes labelled with number 1–5 are contralateral samples and lanes labelled number 6–10 are their respective peri-infarct samples. The lanes marked with X were test samples used for the accuracy of the experiment and were not included for statistical analysis; therefore, they were omitted in final figures. In all contralateral versus ischemic core samples (right columns), the lanes labelled number 1–7 are contralateral samples and the lanes labelled number 8–14 are their respective ischemic core samples. Arrows show the band for the protein of interest according to molecular weight. The other bands are nonspecific which could be due to the many different cell types in brain tissue. Molecular weight marker was loaded in all experiments. M molecular marker.
A combined XPS and computational study of the chemical reduction of BMP-TFSI by lithium
Creators: name: Forster-Tonigold, Katrin
name: Buchner, Florian
name: Bansmann, Joachim
name: Behm, Rolf Jürgen
name: Gross, Axel
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: density functional calculations
subject: ionic liquids
subject: lithium
subject: photoelectron spectroscopy
subject: solid electrolyte interphase
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 620 / Engineering & allied operations
subject: Density functionals
subject: Lithium
subject: Photoelectron spectroscopy
subject: Photoelektronenspektroskopie

description: Employing density functional theory (DFT) calculations and X-ray photoelectron spectroscopy (XPS), we identify products of the reaction of the ionic liquid N,N-butylmethylpyrrolidinum bis(trifluoromethylsulfonyl)imide (BMP-TFSI) with lithium in order to model the initial chemical processes contributing to the formation of the solid electrolyte interphase in batteries. Besides lithium oxide, sulfide, carbide and fluoride, we find lithium cyanide or cyanamide as possible, thermodynamically stable product in the Li-poor regime, whilst Li3N is the stable product in the Li-rich regime. The thermodynamically controlled reaction products as well as larger fragments of TFSI persisting due to kinetic barriers could be identified by a comparison of experimentally and computationally determined core level binding energies.
Deliverable3-6_Game Design_updated.pdf
Creators: name: Cowley, Benjamin
Publisher: name: figshare
Year: 2016
Subjects: subject: 160703 Social Program Evaluation
subject: FOS: Sociology
subject: 170110 Psychological Methodology, Design and Analysis
subject: FOS: Psychology

description: D3.6 is a great example of HOW NOT TO WRITE A DESIGN DOC! It is way too long, filled with text, and was developed over several iterations so that it rambles and is hard to follow, not having been written all at once. Its only function was to satisfy the project management, who liked long documents.
Survey and excavations in the Keekle Coalfield, 1987-90: A study of four post-medieval Cumbrian farmhouses.
Creators: name: Newman, R M
name: Quartermaine, Jamie A
name: Tostevin, Patrick
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 173-202
description: Reports survey and excavation of four farmsteads within the coalfield extension.
Child abuse and neglect and the burden of the COVID‐19 pandemic on families: a series of cases consulted at the german medical child protection hotline
Creators: name: Heimann, Tobias
name: Berthold, Oliver
name: Clemens, Vera
name: Witt, Andreas
name: Fegert, Jörg M.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: child neglect
subject: child sexual abuse
subject: lockdown
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Child abuse
subject: Child abuse, Sexual
subject: COVID-19
subject: Quarantine; Psychology
subject: Kindesmisshandlung
subject: Kind
subject: Sexueller Missbrauch
subject: COVID-19

description: Key Practitioner Messages Increased stress and decreased resources during a lockdown and social distancing can augment the risk for child abuse and neglect during the COVID‐19 pandemic. Health practitioners should continue to be prepared for potentially rising numbers of cases of child abuse and neglect. Child protection services and mental health care should be considered essential and be available for adults and children at all times.
Revolution of chronic lymphocytic leukemia therapy: the chemo-free treatment paradigm
Creators: name: Scheffold, Annika
name: Stilgenbauer, Stephan
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Chronic lymphocytic leukemia
subject: BCR signaling
subject: BTK inhibitor
subject: Venetoclax
subject: BCL2 inhibitors
subject: DDC 610 / Medicine & health

description: Abstract Purpose of Review Over the last years, targeted anticancer therapy with small molecule inhibitors and antibodies has much replaced chemoimmunotherapy, which has been the gold standard of care for patients with chronic lymphocytic leukemia (CLL). Here we give an overview of novel targeted agents used in therapy of chronic lymphocytic leukemia, as well as efforts to overcome resistance development, focusing on approved drugs since they gained high relevance in clinical practice. Recent Findings Novel agents moved to the forefront as a treatment strategy of CLL due to their outstanding efficacy, almost irrespectively of the underlying genetic features. Inhibition of Bruton’s tyrosine kinase (BTK), a key molecule in the B cell receptor pathway, achieved dramatic efficacy even in poor-risk and chemo-refractory patients. Further success was accomplished with venetoclax, which specifically inhibits anti-apoptotic BCL2 and induces apoptosis of CLL cells. Summary Inhibition of BTK or BCL2 is very effective and induces prolongation of progression-free and overall survival. Approved combination treatments such as venetoclax or ibrutinib with obinutuzumab show high responses rates and long remission durations. However, evolution and selection of subclones with continuous treatment leads to resistance towards these novel drugs and disease relapse. Hence, comparison of sequential treatment with combinations and discontinuation of therapy are important aspects which need to be investigated.
Additional file 3 of Repair-related molecular changes during recovery phase of ischemic stroke in female rats
Creators: name: Mostajeran, Maryam
name: Edvinsson, Lars
name: Ahnstedt, Hilda
name: Arkelius, Kajsa
name: Ansar, Saema
Publisher: name: figshare
Year: 2022
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Neuroscience
Developmental Biology

description: Additional file 3: Figure S2. Raw images for Western blot membranes corresponding to Fig. 4A in the manuscript. 3A: Nestin, NeuN and β-actin corresponding to Fig. 4C in the manuscript. In all contralateral samples versus peri-infarct (left columns) the lanes labelled with number 1–5 are contralateral samples and lanes labelled number 6–10 are their respective peri-infarct samples. The lanes marked with X were test samples used for the accuracy of the experiment and were not included for statistical analysis; therefore, they were omitted in final figures. In all contralateral versus ischemic core samples (right columns), the lanes labelled number 1–7 are contralateral samples and the lanes labelled number 8–14 are their respective ischemic core samples. Arrows show the band for the protein of interest according to molecular weight. The other bands are nonspecific which could be due to the many different cell types in brain tissue. Molecular weight marker was loaded in all experiments. M molecular marker.
Deliverable5-1_GameArchitecture_v0-9.pdf
Creators: name: Cowley, Benjamin
Publisher: name: figshare
Year: 2016
Subjects: subject: 160703 Social Program Evaluation
subject: FOS: Sociology

description: D5.1 is written to allow an engineer unfamiliar with the project to pick up the fundamentals of the system without having to learn by trial and error. Since the source code is no longer available, this is included merely for reference.
Patronage and Pietas: the monuments of Lady Anne Clifford.
Creators: name: Wilson, J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 119-142
description: Details one of three monuments erected by Anne Clifford in memory of her mother -- this one located at their last meeting place where Brougham Castle drive meets the Penrith to Appleby road (Cumb).
Additional file 1 of The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion
Creators: name: Wu, Mengliang
name: Downie, Laura E.
name: Hill, Lisa J.
name: Chinnery, Holly R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Figure S1. Corneal nerve regeneration after topical application of 0.24, 1.07 or 4.76 mg/ml decorin at 1 week after corneal injury. Figure S2. Initial central corneal abrasion area at time 0 h, as measured using en face images of the injured corneas acquired using spectral domain optical coherence tomography. Figure S3. Corneal immune cell changes 24 h after injury and topical decorin treatment in Cx3cr1gfp/gfp mice that spontaneously lack intraepithelial DCs.
Differential neural processing of unpleasant sensory stimulation in patients with major depression
Creators: name: Malejko, Kathrin
name: Brown, Rebecca Corinna
name: Plener, Paul L.
name: Bonenberger, Martina
name: Graf, Heiko
name: Abler, Birgit
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Unpleasant sensory stimulation
subject: Depression
subject: fMRI
subject: Electric stimulation
subject: Somatosensory processing
subject: PAIN PERCEPTION
subject: METAANALYSIS
subject: activation
subject: COMPLAINTS
subject: RESPONSES
subject: DISORDER
subject: STRESS
subject: DDC 150 / Psychology

description: Abstract An altered processing of negative salient stimuli has been suggested to play a central role in the pathophysiology of major depression (MD). Besides negative affective and social stimuli, physical pain as a subtype of negative sensory stimulation has been investigated in this context. However, the few neuroimaging studies on unpleasant sensory stimulation or pain processing in MD report heterogeneous findings. Here, we investigated 47 young females, 22 with MD and 25 healthy controls (HC) using fMRI (3.0 T). Four levels of increasingly unpleasant electrical stimulation were applied. Ratings of stimulus intensity were assessed by a visual analogue scale. fMRI-data were analyzed using a 2 × 4 ANOVA. Behavioral results revealed no group differences regarding accuracy of unpleasant stimulation level ratings and sensitivity to stimulation. Regarding neural activation related to increasing levels of unpleasant stimulation, we observed increasing activation of brain regions related to the pain and salient stimulus processing corresponding to increasingly unpleasant stimulation in controls. This modulation was significantly smaller in MD compared to controls, particularly in the dorsal anterior cingulate cortex, the somatosensory cortex, and the posterior insula. Overall, brain regions associated with the processing of unpleasant sensory stimulation, but also associated with the salience network, were highly reactive but less modulated in female patients with MD. These results support and extent findings on altered processing of salience and of negative sensory stimuli even of a non-painful quality in female patients with MD.