title: Identification of genetic markers associated with hyperketonemia patterns in early lactation Holstein cows
title: Identification of genetic markers associated with hyperketonemia patterns in early lactation Holstein cows
titleType: AlternativeTitle
Creators: name: Maria Malane M. Muniz
name: Rita Couto Serrenho
name: Todd Duffield
name: Gerson A de Oliveira Junior
name: Jessica A.A. McArt
name: Christine F. Baes
name: Flavio Schramm Schenkel
name: E. James Squires
Publisher: name: Zenodo
Year: 2024

description: Additional File 1- Table S1. Descriptive statistics for blood BHB concentration (mmol/L) in Holstein cows that were included in an observational study to assess their hyperketonemia patterns in the two weeks postpartum (SP period). Additional File1- Table S2. Descriptive statistics for blood BHB concentration (mmol/L) in Holstein cows that were included in an observational study to assess their hyperketonemia (HYK) patterns in the two weeks post HYK diagnosis and treatment of the condition (FP period). Additional File 1- Table S3. Results indicated differences in blood BHB concentration (mmol/L) among HYK patterns in Holstein cows were included in an observational study to assess their hyperketonemia patterns in the two weeks postpartum followed by diagnosis and treatment of the condition. 
Additional File 2- Spreadsheet S1. List of genes, SNP and their functional consequences associated with HYK identified through cured vs. control (CUR-CON) contrast, Spreadsheet S2. List of genes, SNP and their functional consequences associated with HYK identified through severe vs. control (SEV-CON) contrast. Spreadsheet S3. List of genes, SNP and their functional consequences associated with HYK identified through chronic vs. control (CHR-CON) contrast, Spreadsheet S4. List of genes, SNP and their functional consequences associated with HYK identified through recurrent vs. control (REC-CON) contrast. 
Additional File 3- Spreadsheet S1. Pathways associated with genes identified to cured vs. control (CUR-CON) contrast, Spreadsheet S2. Pathways associated with genes identified to severe vs. control (SEV-CON) contrast, Spreadsheet S3. Pathways associated with genes identified to chronic vs. control (CHR-CON) contrast,Spreadsheet S4. Pathways associated with genes identified to recurrent vs. control (REC-CON) contrast,Spreadsheet S6. Pathways associated with genes set identified among 4 analyzed contrasts (Cured-CUR, severe-SEV, chronic-CHR and recurrent-RECU compared with control-CON, respectively), Spreadsheet S7. Protein Interaction network associated with genes set identified among 4 analyzed contrasts (Cured-CUR, severe-SEV, chronic-CHR and recurrent-RECU compared with control-CON, respectively).
 Additional File4- Spreadsheet S1. Go terms and QTL associated with genes and SNPs related to HYK identified through cured vs. control (CUR-CON) contrast analysis, Spreadsheet S2. Go terms and QTL associated with genes and SNPs related to HYK identified through severe vs. control (SEV-CON) contrast, Spreadsheet S3. Go terms and QTL associated with genes and SNPs related to HYK identified through chronic vs. control (CHR-CON) contrast, Spreadsheet S4. Go terms and QTL associated with genes and SNPs related to HYK were identified through recurrent vs. control (REC-CON) contrast.