cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Survival rates and prognostic factors in right- and left-sided colon cancer stage I–IV: an unselected retrospective single-center trial
Creators: name: Degro, Claudius E.
name: Strozynski, Richard
name: Loch, Florian N.
name: Schineis, Christian
name: Speichinger, Fiona
name: Lee, Lucas D.
name: Margonis, Georgios A.
name: Lauscher, Johannes C.
name: Beyer, Katharina
name: Kreis, Martin E.
name: Kamphues, Carsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Colorectal cancer
subject: Laterality
subject: Survival
subject: Mortality predictors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Colorectal cancer revealed over the last decades a remarkable shift with an increasing proportion of a right- compared to a left-sided tumor location. In the current study, we aimed to disclose clinicopathological differences between right- and left-sided colon cancer (rCC and lCC) with respect to mortality and outcome predictors. Methods: In total, 417 patients with colon cancer stage I-IV were analyzed in the present retrospective single-center study. Survival rates were assessed using the Kaplan-Meier method and uni/multivariate analyses were performed with a Cox proportional hazards regression model. Results: Our study showed no significant difference of the overall survival between rCC and lCC stage I-IV (p = 0.354). Multivariate analysis revealed in the rCC cohort the worst outcome for ASA (American Society of Anesthesiologists) score IV patients (hazard ratio [HR]: 16.0; CI 95%: 2.1-123.5), CEA (carcinoembryonic antigen) blood level > 100 mu g/l (HR: 3.3; CI 95%: 1.2-9.0), increased lymph node ratio of 0.6-1.0 (HR: 5.3; CI 95%: 1.7-16.1), and grade 4 tumors (G4) (HR: 120.6; CI 95%: 6.7-2179.6) whereas in the lCC population, ASA score IV (HR: 8.9; CI 95%: 0.9-91.9), CEA blood level 20.1-100 mu g/l (HR: 5.4; CI 95%: 2.4-12.4), conversion to laparotomy (HR: 14.1; CI 95%: 4.0-49.0), and severe surgical complications (Clavien-Dindo III-IV) (HR: 2.9; CI 95%: 1.5-5.5) were identified as predictors of a diminished overall survival. Conclusion: Laterality disclosed no significant effect on the overall prognosis of colon cancer patients. However, group differences and distinct survival predictors could be identified in rCC and lCC patients.
Supplementary document for Narrowband HgCdTe Infrared Photodetector with Integrated Plasmonic structure - 6317259.pdf
Creators: name: Zhou, Ziji
name: sang, maosheng
name: Zhang, Jinguo
name: Zhengji, Wen
name: Qiu, Qianli
name: Xu, Qianqian
name: Tan, Chong
name: Zhou, Dongjie
name: Qiao, Hui
name: Li, Xiangyang
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplementary materials
title: On the Ethics of Cyber Warfare and International Relations
Creators: name: Fitzpatrick, Brenna
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Cyber warfare
subject: Just war theory
subject: China
subject: United States
subject: International relations
subject: Ethics

description: This thesis interrogates the development of cyber warfare and how state governments engage cyber warfare. Cyber warfare is a highly modernized form of conflict between state actors, calling for those studying conflict to understand it as much as possible. While researching and writing this thesis, the author conducted a literature search and reviews of news articles, government documents, government press releases, and statements by government officials.
Candida periprosthetic joint infections — risk factors and outcome between albicans and non-albicans strains
Creators: name: Karczewski, Daniel
name: Ren, Yi
name: Andronic, Octavian
name: Akgün, Doruk
name: Perka, Carsten
name: Müller, Michael
name: Kienzle, Arne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Periprosthetic joint infection
subject: Candida
subject: Fungal infection
subject: Revision arthroplasty
subject: Total knee arthroplasty
subject: Total hip arthroplasty
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Despite its scarcity, fungal periprosthetic joint infection (PJI) is of great clinical relevance as diagnosis and treatment are highly challenging. Previous analyses focused on the treatment rather than the role of the causative fungal agent on clinical outcome. This is the largest study of its kind to evaluate Candida strain-dependent differences in patients with fungal PJI. Methods: We retrospectively analyzed 29 patients who underwent surgical intervention due to Candida hip or knee PJI in our department from 2010 to 2018. PJI was defined according to IDSA, recurrent PJI according to modified Delphi consensus criteria. Statistical analysis was performed using t-test, chi-square test with Yates correction, and log rank test. Results: Besides age and affected joint, no significant differences were found between Candida albicans and non-albicans PJI patients (75.83 versus 64.11 years, p = 0.012; 12 hip versus two knee cases, p = 0.013). Most patients received two- (27.59%) or three-stage exchange surgery (41.38%). There was a statistical trend towards an increase in surgery needed in non-albicans Candida PJI (2.92 versus 2.12; p = 0.103). After initial Candida PJI treatment, functional prosthesis implantation was achieved in 72.41% of all patients. At last follow-up, infection-free survival was at 26.79% in Candida albicans versus 72.00% in non-albicans PJI (p = 0.046). Conclusions: In this study, we found infection-free survival rates to be significantly decreased in patients with albicans compared to non-albicans Candida PJI. While age and affected joint might play a confounding role, we speculate the causative pathogen to play a decisive role in disease progression.
Retrospective analysis of treatment decisions and clinical outcome of Lisfranc injuries: operative vs. conservative treatment
Creators: name: Graef, Josefine
name: Tsitsilonis, Serafeim
name: Niemann, Marcel
name: Gehlen, Tobias
name: Nadler, Pascal
name: Graef, Frank
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Lisfranc
subject: Tarsometatarsal injury
subject: Distortion trauma
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Lisfranc injuries are rare and often pose a challenge for surgeons, particularly in initially missed or neglected cases. The evidence on which subtypes of Lisfranc injuries are suitable for conservative treatment or should undergo surgery is low. The aim of this study was to retrospectively analyze treatment decisions of Lisfranc injuries and the clinical outcome of these patients within the last ten years. Methods: All patients treated due to a Lisfranc injury in a German level I trauma centre from January 2011 until December 2020 were included in this study. Radiologic images and medical data from the patient files were analyzed concerning the classification of injury, specific radiologic variables, such as the Buehren criteria, patient baseline characteristics, and patient outcome reported with the Foot Function Index (FFI). Results: Ninety-nine patients were included in this study (conservative = 20, operative = 79). The overall clinical outcome assessed by the FFI was good (FFI sum 23.93, SD 24.93); patients that were identified as suitable for conservative treatment did not show inferior functional results. Qualitative radiological factors like the grade of displacement and the trauma mechanism were more strongly associated with the decision for surgical treatment than quantitative radiologic factors such as the distance from the first to the second metatarsal bone. Conclusion: If the indication for conservative or operative treatment of Lisfranc injuries is determined correctly, the clinical outcome can be comparable. These decisions should be based on several factors including quantitative and qualitative radiologic criteria, as well as the trauma mechanism.
title: Development and Validation of an Instrument to Measure Multidimensional, Instruction-Specific Student Engagement in Undergraduate Mathematics
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: This study aimed to develop and provide initial validity evidence for an instrument to measure multidimensional, instruction-specific engagement in undergraduate mathematics-based classes. Multidimensionality included three engagement dimensions: behavioral, cognitive, and emotional (Fredricks et al., 2004). Instructional specificity included four instruction types: lecture, whole-class interaction, individual work, and group work. The study design had several phases. First, I reviewed the literature and conducted exploratory interviews to inform item writing. Then, an iterative cycle of pretesting via cognitive interviews, evaluating via expert reviews, and revising was implemented. Finally, the instrument was field-tested. Results provided initial validity evidence for combining multidimensionality and instructional specificity in engagement measurement. Yet, changes to the instrument’s internal structure occurred. First, among behaviors in whole-class interaction, active behaviors separated out from passive behaviors. Second, excluding active behaviors in whole-class interaction, behavioral and cognitive engagement dimensions were not differentiated empirically and, therefore, were collapsed. Thus, the final version of the instrument measures nine multidimensional, instruction-specific engagement constructs. Additionally, I found that student engagement may be better conceptualized as a formative construct rather than a reflective construct. The instrument is designed to enable educators to identify how and where students are not engaged. This information would allow educators to develop more targeted and, therefore, more efficient interventions. The instrument is also designed to be used in research that aims to inform the development of such interventions. In particular, it will enable researchers to determine which instructional factors affect specific types of engagement and how these factors exert their influence.
Spatiality of Social Stress Experienced by Refugee Women in Initial Reception Centers
Creators: name: Nassim, Mehran
name: Jinan, Abi Jumaa
name: Felicia, Lazaridou
name: Naika, Foroutan
name: Andreas, Heinz
name: Ulrike, Kluge
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Spatiality
subject: Social stress
subject: Refugee women
subject: Reception centers
subject: Privacy
subject: Resettlement
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: This study takes an interdisciplinary approach to understanding the multi-dimensionality of social stress within the spatiality of initial refugee reception centers in Berlin. By focusing particularly on the experiences of women who fled from Syria and Afghanistan, it situates this humanitarian issue within an analytical framework of gender-sensitive and culturally sensitive research and policymaking. Through qualitative interviews with 11 refugee women, the connection between the spatiality of initial reception centers and social stress is explored. This is done by thematically coding the data collected in the context of nine different initial reception centers across various districts in the city of Berlin. The study shows that in terms of the intercultural needs and practices of these women, social stress is triggered by a lack of essential privacy within the spatiality of these structures. However, privacy is not limited to a physical enclosure-it is about having control/freedom over different aspects of everyday life. This article highlights intercultural gaps in gender-sensitive and protection considerations during humanitarian responses.
THE NUMBER 2
Creators: name: UBAT, JOEL T.
Publisher: name: BINAS PUBLISHING
Year: 2025
Subjects: Number

description: PACIFICUS: A Literary Magazine by Binas Publishing (Volume 1, Issue 1)

 

PACIFICUS is a literary magazine by Binas Publishing that celebrates the power of words through a diverse collection of poetry, short stories, essays, and creative works. With its inaugural issue, PACIFICUS Volume 1, Issue 1 sets the stage for a platform where writers and artists can share their voices, perspectives, and imagination.

 

This edition features compelling narratives, thought-provoking reflections, and artistic expressions that resonate with readers across different backgrounds. Whether exploring themes of identity, resilience, culture, or the human experience, PACIFICUS embodies the essence of storytelling that inspires and connects.

 

As a publication dedicated to fostering literary excellence, PACIFICUS aims to nurture emerging and established writers while enriching the literary landscape. Each issue aspires to be a testament to creativity, insight, and the enduring impact of literature.
Supplementary document for 3D stimulated Raman spectral imaging of water dynamics associated with pectin-glycocalyceal entanglement - 6317468.pdf
Creators: name: Floess, Moritz
name: Steinle, Tobias
name: Werner, Florian
name: Wang, Yunshan
name: Wagner, Willi
name: Steinle, Verena
name: Liu, Betty
name: Zheng, Yifan
name: Chen, Zi
name: Ackermann, Maximilian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement Document
Detection of pre-existing SARS-CoV-2-reactive T cells in unexposed renal transplant patients
Creators: name: Anft, Moritz
name: Blazquez-Navarro, Arturo
name: Stervbo, Ulrik
name: Skrzypczyk, Sarah
name: Witzke, Oliver
name: Wirth, Rainer
name: Choi, Mira
name: Hugo, Christian
name: Reinke, Petra
name: Meister, Toni Luise
name: Steinmann, Eike
name: Pfaender, Stephanie
name: Schenker, Peter
name: Viebahn, Richard
name: Westhoff, Timm H.
name: Babel, Nina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Renal transplantation
subject: Sars-CoV-2
subject: Antigen-spcific T cells
subject: Immunosuppression
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Recent data demonstrate potentially protective pre-existing T cells reactive against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in samples of healthy blood donors, collected before the SARS-CoV-2 pandemic. Whether pre-existing immunity is also detectable in immunosuppressed patients is currently not known. Methods: Fifty-seven patients were included in this case-control study. We compared the frequency of SARS-CoV-2-reactive T cells in the samples of 20 renal transplant (RTx) patients to 20 age/gender matched non-immunosuppressed/immune competent healthy individuals collected before the onset of the SARS-CoV-2 pandemic. Seventeen coronavirus disease 2019 (COVID-19) patients were used as positive controls. T cell reactivity against Spike-, Nucleocapsid-, and Membrane-SARS-CoV-2 proteins were analyzed by multi-parameter flow cytometry. Antibodies were analyzed by neutralization assay. Results: Pre-existing SARS-CoV-2-reactive T cells were detected in the majority of unexposed patients and healthy individuals. In RTx patients, 13/20 showed CD4(+) T cells reactive against at least one SARS-CoV-2 protein. CD8(+) T cells reactive against at least one SARS-CoV-2 protein were demonstrated in 12/20 of RTx patients. The frequency and Th1 cytokine expression pattern of pre-formed SARS-CoV-2 reactive T cells did not differ between RTx and non-immunosuppressed healthy individuals. Conclusions: This study shows that the magnitude and functionality of pre-existing SARS-CoV-2 reactive T cell in transplant patients is non-inferior compared to the immune competent cohort. Although several pro-inflammatory cytokines were produced by the detected T cells, further studies are required to prove their antiviral protection.
In vitro validation and characterization of pulsed inhaled nitric oxide administration during early inspiration
Creators: name: Pickerodt, Philipp A.
name: Hofferberth, Moritz B. T.
name: Busch, Thilo
name: Russ, Martin
name: Taher, Mahdi
name: Boemke, Willehad
name: Weber-Carstens, Steffen
name: Köbrich, Rainer
name: Swenson, Erik
name: Deja, Maria
name: Francis, Roland C. E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Nitric oxide
subject: Inhalation
subject: PiNO
subject: Mechanical ventilation
subject: Artificial lung
subject: ARDS
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Admixture of nitric oxide (NO) to the gas inspired with mechanical ventilation can be achieved through continuous, timed, or pulsed injection of NO into the inspiratory limb. The dose and timing of NO injection govern the inspired and intrapulmonary effect site concentrations achieved with different administration modes. Here we test the effectiveness and target reliability of a new mode injecting pulsed NO boluses exclusively during early inspiration. Methods: An in vitro lung model was operated under various ventilator settings. Admixture of NO through injection into the inspiratory limb was timed either (i) selectively during early inspiration ("pulsed delivery"), or as customary, (ii) during inspiratory time or (iii) the entire respiratory cycle. Set NO target concentrations of 5-40 parts per million (ppm) were tested for agreement with the yield NO concentrations measured at various sites in the inspiratory limb, to assess the effectiveness of these NO administration modes. Results: Pulsed delivery produced inspiratory NO concentrations comparable with those of customary modes of NO administration. At low (450 ml) and ultra-low (230 ml) tidal volumes, pulsed delivery yielded better agreement of the set target (up to 40 ppm) and inspiratory NO concentrations as compared to customary modes. Pulsed delivery with NO injection close to the artificial lung yielded higher intrapulmonary NO concentrations than with NO injection close to the ventilator. The maximum inspiratory NO concentration observed in the trachea (68 +/- 30 ppm) occurred with pulsed delivery at a set target of 40 ppm. Conclusion: Pulsed early inspiratory phase NO injection is as effective as continuous or non-selective admixture of NO to inspired gas and may confer improved target reliability, especially at low, lung protective tidal volumes.
Strategies to Enhance Retention in a Cohort Study Among Adults of Turkish Descent Living in Berlin
Creators: name: Dornquast, Christina
name: Reinhold, Thomas
name: Solak, Saliha
name: Durak, Melike
name: Becher, Heiko
name: Riens, Burgi
name: Icke, Katja
name: Danquah, Ina
name: Willich, Stefan N.
name: Keil, Thomas
name: Krist, Lilian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Retention strategies
subject: Cohort studies
subject: Migrants
subject: Participation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Retention is important for statistical power and external validity in long-term cohort studies. The aims of our study were to evaluate different retention strategies within a cohort study of adults of Turkish descent in Berlin, Germany, and to compare participants and non-participants. In 2011-2012, a population-based study was conducted among adults of Turkish descent to primarily examine recruitment strategies. 6 years later, the participants were re-contacted and invited to complete a self-report questionnaire regarding their health status, health care utilization, and satisfaction with medical services. The retention strategy comprised letters in both German and Turkish, phone calls, and home visits (by bilingual staff). We calculated the response rate and retention rate, using definitions of the American Association for Public Opinion Research, as well as the relative retention rate for each level of contact. Associations of baseline recruitment strategy, sociodemographic, migration-related and health-related factors with retention were investigated by logistic regression analysis. Of 557 persons contacted, 249 (44.7%) completed the questionnaire. This was 50.1% of those whose contact information was available. The relative retention rate was lowest for phone calls (8.9%) and highest for home visits (18.4%). Participants were more often non-smokers and German citizens than non-participants. For all remaining factors, no association with retention was found. In this study, among adults of Turkish descent, the retention rate increased considerably with every additional level of contact. Implementation of comprehensive retention strategies provided by culturally matched study personnel may lead to higher validity and statistical power in studies on migrant health issues.
A novel concept of screening for subgrouping factors for the association between socioeconomic status and respiratory allergies
Creators: name: Muysers, Christoph
name: Messina, Fabrizio
name: Keil, Thomas
name: Roll, Stephanie
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: "Subscreen" R package
subject: Epidemiology survey
subject: Asthma
subject: Rhinitis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The new subgroup screening tool "subscreen" aims to understand the unclear and complex association between socioeconomic status (SES) and childhood allergy. This software R package has been successfully used in clinical trials but not in large population-based studies. Objective: To screen and identify subgrouping factors explaining their impact on the association between SES and respiratory allergies in childhood and youth. Methods: Using the national German childhood and youth survey dataset (KiGGS Wave 2), we included 56 suspected subgrouping factors to investigate the association between SES (low vs. high) and allergic rhinitis and/or asthma in an exploratory manner. The package enabled a comprehensive overview of odds ratios when considering the SES impact per subgroup and analogously all disease proportions per subgroup. Result: Among the 56 candidate factors, striking subgrouping factors were identified; e.g., if mothers were younger and in the low SES group, their children had a higher risk of asthma. In addition children of the teen's age were associated with increased risks in the low SES group. For the crude proportions, factors such as (parental) smoking or having had no "contact with farm animals" were identified as strong risk factors for rhinitis. Significance: The "subscreen" package enabled the detection of notable subgroups for further investigations exemplarily for similar epidemiological research questions.
title: Unearth
Creators: name: Lillis, Jennifer
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Unearth
subject: Papermaking
subject: Installation
subject: Transformation
subject: Sculpture

description: Unearth is a poetic exploration of the function, intention and transformation of art within the context of ritual and sacred spaces. This thesis will discuss the construction of the exhibition, unearth, through the different stages of an initiation sequence. The paper describes the transformation of the gallery into a ritualized physical and mytho-poetic narrative space. Other topics will cover: life history of objects, the embodiment of material in ritual, caverns as sacred space, the essence of language, and conception of being.
Neural correlates of RDoC-specific cognitive processes in a high-functional autistic patient: a statistically validated case report
Creators: name: Daedelow, Laura S.
name: Beck, Anne
name: Romund, Lydia
name: Mascarell-Maricic, Lea
name: Dziobek, Isabel
name: Romanczuk-Seiferth, Nina
name: Wüstenberg, Torsten
name: Heinz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Autism spectrum disorder
subject: Research Domain Criteria
subject: Emotion processing
subject: Reward processing
subject: Working memory
subject: Neuroimaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The level of functioning of individuals with autism spectrum disorder (ASD) varies widely. To better understand the neurobiological mechanism associated with high-functioning ASD, we studied the rare case of a female patient with an exceptional professional career in the highly competitive academic field of Mathematics. According to the Research Domain Criteria (RDoC) approach, which proposes to describe the basic dimensions of functioning by integrating different levels of information, we conducted four fMRI experiments targeting the (1) social processes domain (Theory of mind (ToM) and face matching), (2) positive valence domain (reward processing), and (3) cognitive domain (N-back). Patient's data were compared to data of 14 healthy controls (HC). Additionally, we assessed the subjective experience of our case during the experiments. The patient showed increased response times during face matching and achieved a higher total gain in the Reward task, whereas her performance in N-back and ToM was similar to HC. Her brain function differed mainly in the positive valence and cognitive domains. During reward processing, she showed reduced activity in a left-hemispheric frontal network and cortical midline structures but increased connectivity within this network. During the working memory task patients' brain activity and connectivity in left-hemispheric temporo-frontal regions were elevated. In the ToM task, activity in posterior cingulate cortex and temporo-parietal junction was reduced. We suggest that the high level of functioning in our patient is rather related to the effects in brain connectivity than to local cortical information processing and that subjective report provides a fruitful framework for interpretation.
Supplementary document for Continuous wave multi-pass imaging flow cytometry - 6317652.pdf
Creators: name: Israel, Yonatan
name: Kasevich, Mark
name: Klopfer, Brannon
name: Reynolds, Joshua
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Detailed discussion of bright-field multi-pass imaging that includes phase contrast, absorption contrast, and optical losses. We show that multi-pass techniques saturate the Cramer-Rao bound for loss sensitivity.
Fixing nitrogen: understanding ammonia electrosynthesis through advanced characterisation
Creators: name: Westhead, Olivia
Publisher: name: Imperial College London
Year: 2023

description: Despite being hailed as one of the most influential inventions of the twentieth century, ammonia production via the Haber-Bosch process is one of the most environmentally damaging industries. A sustainable, distributed mode of ammonia synthesis would democratise fertiliser access, as well as reducing the environmental impact of both use and production of nitrogen-based fertilisers. Electrochemical nitrogen reduction could provide the answer. Non-aqueous lithium-mediated nitrogen reduction has been rigorously verified as capable of true nitrogen reduction to ammonia. Here, a lithium based active surface is deposited in-situ on a metallic current collector in an organic electrolyte. Similar to a lithium-ion battery, a Solid Electrolyte Interphase (SEI) is formed via decomposition of the organic electrolyte. This SEI is critical for stable and selective nitrogen reduction. Although much progress has been made, relative to other electrochemical reactions, there is still comparatively little is known about the fundamental science behind lithium-mediated nitrogen reduction. This Thesis seeks to improve fundamental understanding of both the anodic and cathodic reactions in lithium mediated nitrogen reduction. A technique for the determination of the reversible hydrogen electrode (RHE) potential in the lithium-mediated nitrogen reduction electrolyte is described, allowing for the determination of the overpotential past the thermodynamic equilibrium and measurement of energy efficiency. Further discussions of hydrogen redox reactions in the lithium-mediated nitrogen reduction electrolyte are presented in the context of a proof-of-concept study aiming to eliminate the poisoning of platinum based electrodes from organics and the salt anion. Bulk electrolyte properties are linked to SEI formation and nitrogen reduction performance, and advanced characterisation techniques used to gain further insight into the nitrogen reduction SEI. The primary takeaway from the SEI characterisation studies is that the lithium-mediated nitrogen reduction system sits within a narrow Goldilocks zone, where the conditions are just right for optimal performance.
Prognostic value of ‘late’ electroencephalography recordings in patients with cardiopulmonal resuscitation after cardiac arrest
Creators: name: Doerrfuss, Jakob I.
name: Kowski, Alexander B.
name: Holtkamp, Martin
name: Thinius, Moritz
name: Leithner, Christoph
name: Storm, Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: EEG
subject: Predictive value of tests
subject: Resuscitation
subject: Outcome
subject: Targeted temperature management
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Electroencephalography (EEG) significantly contributes to the neuroprognostication after resuscitation from cardiac arrest. Recent studies suggest that the prognostic value of EEG is highest for continuous recording within the first days after cardiac arrest. Early continuous EEG, however, is not available in all hospitals. In this observational study, we sought to evaluate the predictive value of a 'late' EEG recording 5-14 days after cardiac arrest without sedatives. Methods: We retrospectively analyzed EEG data in consecutive adult patients treated at the medical intensive care units (ICU) of the Charite-Universitatsmedizin Berlin. Outcome was assessed as cerebral performance category (CPC) at discharge from ICU, with an unfavorable outcome being defined as CPC 4 and 5. Results: In 187 patients, a 'late' EEG recording was performed. Of these patients, 127 were without continuous administration of sedative agents for at least 24 h before the EEG recording. In this patient group, a continuously suppressed background activity < 10 mu V predicted an unfavorable outcome with a sensitivity of 31% (95% confidence interval (CI) 20-45) and a specificity of 99% (95% CI 91-100). In patients with suppressed background activity and generalized periodic discharges, sensitivity was 15% (95% CI 7-27) and specificity was 100% (95% CI 94-100). GPDs on unsuppressed background activity were associated with a sensitivity of 42% (95% CI 29-46) and a specificity of 92% (95% CI 82-97). Conclusions: A 'late' EEG performed 5 to 14 days after resuscitation from cardiac arrest can aide in prognosticating functional outcome. A suppressed EEG background activity in this time period indicates poor outcome.
CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness
Creators: name: Lewis, Richard
name: Maurer, H. Carlo
name: Singh, Nikita
name: Gonzalez-Menendez, Irene
name: Wirth, Matthias
name: Schick, Markus
name: Zhang, Le
name: Isaakidis, Konstandina
name: Scherger, Anna Katharina
name: Schulze, Veronika
name: Lu, Junyan
name: Zenz, Thorsten
name: Steiger, Katja
name: Rad, Roland
name: Quintanilla-Martinez, Leticia
name: Espeli, Marion
name: Balabanian, Karl
name: Keller, Ulrich
name: Habringer, Stefan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: CXCR4 hyperactivation
subject: TCL1
subject: CLL development
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression, and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4(C1013G)) that hyperactivates CXCR4 signaling, we identified CXCR4 as a crucial activator of multiple key oncogenic pathways. CXCR4 hyperactivation resulted in an expansion of transitional B1 lymphocytes, which represent the precursors of chronic lymphocytic leukemia (CLL). Indeed, CXCR4 hyperactivation led to a significant acceleration of disease onset and a more aggressive phenotype in the murine E mu-TCL1 CLL model. Hyperactivated CXCR4 signaling cooperated with TCL1 to cause a distinct oncogenic transcriptional program in B cells, characterized by PLK1/FOXM1-associated pathways. In accordance, E mu-TCL1;CXCR4(C1013G) B cells enriched a transcriptional signature from patients with Richter's syndrome, an aggressive transformation of CLL. Notably, MYC activation in aggressive lymphoma was associated with increased CXCR4 expression. In line with this finding, additional hyperactive CXCR4 signaling in the E mu-Myc mouse, a model of aggressive B-cell cancer, did not impact survival. In summary, we here identify CXCR4 hyperactivation as a co-driver of an aggressive lymphoma phenotype.
title: Assessment of Flash Flood Hazard in A Semiarid Area Through Satellite and Social Media Data Mining
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Data Mining
subject: Flash Flood
subject: Flood
subject: GIS
subject: Satellite
subject: Social Media
subject: Geographic information science and geodesy
subject: Geography

description: Since 2009, flood events have shown an increasing trend in Saudi Arabia. Moreover, most floods occur in cities and may be related to rapid urbanization. Meanwhile, flooding in semiarid areas is usually short-term flash floods within small areas. Therefore, satellite-based flash flood observations are still challenging, while conventional observations are usually sparse in semiarid areas. This study combines machine learning techniques, the statistical analysis of frequency ratio, the logistic regression, and the analytic hierarchy process (AHP) method to identify flood-prone areas in a semiarid area in southern Saudi Arabia. This study integrates thirteen flood-contributing factors such as rainfall, elevation, aspect, slope, flow accumulation, stream power index (SPI), topographic wetness index (TWI), drainage density, distance from the river, distance from roads, soil types, urban area as represented by impervious area, and normalized difference vegetation index (NDVI). Ground observations from social media, such as Twitter and YouTube, validate the prediction results. The objectives of this study include: First, analyze the impacts of the selected thirteen flood-contributing factors. Second, build a decision-tree model between a flash flood and the influencing factors. Third, create a flood susceptibility map in southern Saudi Arabia using the AHP method. The susceptibility map shows the levels of flood risk and their respective percentages in the study area: very low 5%, low 44%, moderate 39%, high 1%, and very high 11%. The results are validated against the ground observations from social media, such as Twitter and YouTube. This research indicates 30.76% commission error and 35.71% omission error from the derived flood susceptibility map with very high and high flood risks, while the overall accuracy can reach 90.37%.
Benefits of Using a Surgeons Email List in Healthcare Marketing
Creators: name: Larry Thomas
Publisher: name: Larry Thomas
Year: 2025

description: A Surgeons Email List enhances healthcare marketing by enabling direct, targeted communication with verified surgical professionals. It boosts campaign efficiency, improves conversion rates, and fosters strong professional relationships. This tool supports personalized outreach, ensures cost-effective strategies, and keeps your brand ahead in a competitive healthcare landscape through data-driven engagement.
QONUNCHILIK TARTIBGA SOLISH TA'SIRINI BAHOLASH TUSHUNCHASI VA METODOLOGIYASI
Creators: name: Jo'ramurodov, Dilshod
Publisher: name: Zenodo
Year: 2025

description: Maqolada qonunchilik tartibga solishning ta’sirini baholashning tushunchasi va metodologiyasi tahlil qilinadi. Ushbu ilmiy ishda, qonunchilikning samarali ta’sirini aniqlash va baholashning metodologik asoslari, asosan, iqtisodiy, ijtimoiy va siyosiy aspektlardan yondashiladi. Shuningdek, qonunchilik jarayonlarining samaradorligini o‘lchash uchun zarur bo‘lgan metrikalar va metodlar muhokama qilinadi. Maqola qonunchilikni samarali tarzda tartibga solish va ijtimoiy-iqtisodiy tizimga bo‘lgan ta’sirini yaxshilashga qaratilgan aniq tavsiyalarni taqdim etadi.
Tackling the frailty burden with an integrative value-based approach: results from a mixed-methods study
Creators: name: Fürstenau, Daniel
name: Haneke, Hannah
name: Spies, Claudia
name: Walz, Tim
name: Schewina, Kai
name: Höft, Moritz
name: Mörgeli, Rudolf
name: Balzer, Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Frailty
subject: Value-based health care
subject: Digital health solutions
subject: Barriers
subject: Perioperative process
subject: Integrative approach
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aim: The purpose of this paper is to investigate the implementation of value-based care principles in the context of frailty in the perioperative process, highlighting the importance of an integrative perspective considering medical and patient-centric outcomes as well as costs. Subject and methods: This mixed-methods study employs a sequential design. Qualitative observational data were used to identify needs and barriers for implementing value-based principles, and quantitative methods were subsequently used to demonstrate the value of employing such an approach using data gathered from n = 952 patients. Propensity score matching was applied to identify the frailty-associated costs of the inpatient setting for n = 381 non-frail and n = 381 (pre-)frail patients, in particular considering patient-centric outcomes. Results: The qualitative analysis identified three main challenges when implementing value-based principles in the context of perioperative care and frailty, namely challenges related to the cost, patient-centric, and integrative perspectives. In addressing these shortcomings, a quantitative analysis of a propensity score-matched sample of patients undergoing surgery shows additional frailty-associated costs of 3583.01 [1654.92; 5511.04] EUR for (pre-)frail patients and the influence of individual patient-centric attributes. Effect size Cohen's d was 0.26. Conclusion: The results demonstrate that frailty should be considered from an integrative perspective, taking cost, patient-centered outcomes, and medical outcomes into account simultaneously. The results also show the value of a research design which uses qualitative data for the identification of needs and barriers, as well as quantitative data for demonstrating the usefulness of the conceived value-based approach to perioperative care delivery.
title: A Qualitative Comparison of NCAA Coach Intended and Athlete Perception of Motivational Behavior
Creators: name: Blank, Megan
Publisher: name: George Mason University
Year: 2018
Subjects: subject: Coaching behavior
subject: NCAA athlete perceptions
subject: Motivational behavior
subject: NCAA athlete motivation
subject: Perceptions of motivation

description: This research study evaluated coaching behavior at the NCAA Division I mid-major level. It used phenomenology to describe coaches' experiences as they motivated athletes, and athletes' experiences as they interpreted their coaches' motivational behavior. Four coaches and eight athletes participated in this study from team sports in the Mid-Atlantic region. The research evaluated real, lived experiences to better comprehend how coaches can use their behavior to develop intrinsic motivation among their athletes, improve performance, and help their athletes maintain a healthy balance between their academic, athletic, and personal lives. Results indicated coaches' and athletes' perceptions were similar in areas of positive feedback and recognition, relatedness and connectedness, and instruction. Their perceptions varied concerning negative feedback and indicated there may be strategies for coaches to administer more effective feedback to their athletes.
Supplementary document for Continuous variable spin-orbit total angular momentum entanglement on higher-order Poincaré sphere - 6318210.pdf
Creators: name: Guo, Hui
name: Liu, Na
name: Sun, Hengxin
name: Liu, Kui
name: Gao, Jiangrui
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The description of the experimental scheme details and the power spectrum density data.
title: Project 7: Outcomes of Re-transplantation in Intestine-Alone and Liver-Intestinal Transplants
Creators: name: Paul, Krittika
name: Sankara, Veda
name: Yu, Claire
Publisher: name: George Mason University
Year: 2024

description: Objective: The study investigated how transplant outcomes (graft failure and patient mortality) vary by re-transplantation among intestine-alone and liver-intestinal transplant patients.
Robot-assisted pancreatic surgery—optimized operating procedures: set-up, port placement, surgical steps
Creators: name: Felsenstein, Matthäus
name: Hillebrandt, Karl H.
name: Timmermann, Lea
name: Feist, Mathilde
name: Benzing, Christian
name: Schmelzle, Moritz
name: Pratschke, Johann
name: Malinka, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Robotic-assisted pancreatic surgery
subject: Pancreatic surgery
subject: Standard operating procedures
subject: One fits all
subject: Reversed 6-to-6 approach
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Even in most complex surgical settings, recent advances in minimal-invasive technologies have made the application of robotic-assisted devices more viable. Due to ever increasing experience and expertise, many large international centers now offer robotic-assisted pancreatic surgery as a preferred alternative. In general however, pancreatic operations are still associated with high morbidity and mortality, while robotic-assisted techniques still require significant learning curves. As a prospective post-marketing trial, we have established optimized operating procedures at our clinic. This manuscript intends to publicize our standardized methodology, including pre-operative preparation, surgical set-up as well as the surgeons' step-by-step actions when using pancreatic-assisted robotic surgery. This manuscript is based on our institutional experience as a high-volume pancreas operating center. We introduce novel concepts that should standardize, facilitate and economize the surgical steps in all types of robotic-assisted pancreatic surgery. The "One Fits All" principle enables single port placement irrespective of the pancreatic procedure, while the "Reversed 6-to-6 Approach" offers an optimized manual for pancreatic surgeons using the robotic console. Novel and standardized surgical concepts could guide new centers to establish a robust, efficient and safe robotic-assisted pancreatic surgery program.
Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief
Creators: name: Mousa, Shaaban A.
name: Shaqura, Mohammed
name: Khalefa, Baled I.
name: Li, Li
name: Al-Madol, Mohammed
name: Treskatsch, Sascha
name: Schäfer, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Somatic pain
subject: Corticotropin-releasing factor
subject: Spinal cord
subject: ENK-immunoreactive interneurons
subject: Immunofluorescence
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Corticotropin-releasing factor (CRF) orchestrates our body's response to stressful stimuli. Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptor subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial. Thus, the aim of the present study was to examine CRF-R1 and CRF-R2 expression within the spinal cord of rats with Freund's complete adjuvant-induced unilateral inflammation of the hind paw using reverse transcriptase polymerase chain reaction, Western blot, radioligand binding, and immunofluorescence confocal analysis. Moreover, the antinociceptive effects of intrathecal (i.t.) CRF were measured by paw pressure algesiometer and their possible antagonism by selective antagonists for CRF-R1 and/or CRF-R2 as well as for opioid receptors. Our results demonstrated a preference for the expression of CRF-R2 over CRF-R1 mRNA, protein, binding sites and immunoreactivity in the dorsal horn of the rat spinal cord. Consistently, CRF as well as CRF-R2 agonists elicited potent dose-dependent antinociceptive effects which were antagonized by the i.t. CRF-R2 selective antagonist K41498, but not by the CRF-R1 selective antagonist NBI35965. In addition, i.t. applied opioid antagonist naloxone dose-dependently abolished the i.t. CRF- as well as CRF-R2 agonist-elicited inhibition of somatic pain. Importantly, double immunofluorescence confocal microscopy of the spinal dorsal horn showed CRF-R2 on enkephalin (ENK)-containing inhibitory interneurons in close opposition of incoming mu-opioid receptor-immunoreactive nociceptive neurons. CRF-R2 was, however, not seen on pre- or on postsynaptic sensory neurons of the spinal cord. Taken together, these findings suggest that i.t. CRF or CRF-R2 agonists inhibit somatic inflammatory pain predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons which finally results in endogenous opioid-mediated pain inhibition.