Analysis of Over 10,000 Cases Finds No Association between Previously Reported Candidate Polymorphisms and Ovarian Cancer Outcome
Creators: name: White, Kristen L.
name: Vierkant, Robert A.
name: Fogarty, Zachary C.
name: Charbonneau, Bridget
name: Block, Matthew S.
name: Pharoah, Paul D.P.
name: Chenevix-Trench, Georgia
name: Rossing, Mary Ann
name: Cramer, Daniel W.
name: Pearce, Celeste Leigh
name: Schildkraut, Joellen M.
name: Menon, Usha
name: Kjaer, Sussanne Kruger
name: Levine, Douglas A.
name: Gronwald, Jacek
name: Culver, Hoda Anton
name: Whittemore, Alice S.
name: Karlan, Beth Y.
name: Lambrechts, Diether
name: Kupryjanczyk, Jolanta
name: Wentzensen, Nicolas
name: Chang-Claude, Jenny
name: Bandera, Elisa V.
name: Hogdall, Estrid
name: Heitz, Florian
name: Kaye, Stanley B.
name: Fasching, Peter A.
name: Campbell, Ian
name: Pejovic, Tanja
name: Goodman, Marc T.
name: Bean, Yukie
name: Lurie, Galina
name: Eccles, Diana
name: Hein, Alexander
name: Beckmann, Matthias W.
name: Ekici, Arif B.
name: Paul, James
name: Brown, Robert
name: Flanagan, James M.
name: Harter, Philipp
name: Schwaab, Ira
name: Du Bois, Andreas
name: Hogdall, Claus K.
name: Lundvall, Lene
name: Olson, Sara H.
name: Orlow, Irene
name: Paddock, Lisa E.
name: Rudolph, Anja
name: Eilber, Ursula
name: Dansonka-Mieszkowska, Agnieszka
name: Rzepecka, Iwona K.
name: Ziolkowska-Seta, Izabela
name: Brinton, Louise
name: Yang, Hannah
name: Garcia-Closas, Montserrat
name: Despierre, Evelyn
name: Lambrechts, Sandrina
name: Vergote, Ignace
name: Walsh, Christine
name: Lester, Jenny
name: Sieh, Weiva
name: McGuire, Valerie
name: Rothstein, Joseph H.
name: Ziogas, Argyrios
name: Lubinksi, Jan
name: Cybulski, Cezary
name: Menkiszak, Janusz
name: Jensen, Allan
name: Gayther, Simon A.
name: Ramus, Susan J.
name: Gentry-Maharaj, Aleksandra
name: Berchuck, Andrew
name: Wu, Anna H.
name: Pike, Malcolm C.
name: Van Den Berg, David
name: Terry, Kathryn L.
name: Vitonis, Allison F.
name: Doherty, Jennifer A.
name: Johnatty, Sharon E.
name: DeFazio, Anna
name: Song, Honglin
name: Tyrer, Jonathan
name: Sellers, Thomas A.
name: Phelan, Catherine M.
name: Kalli, Kimberly R.
name: Cunningham, Julie M.
name: Fridley, Brooke L.
name: Goode, Ellen L.
Publisher: name: Columbia University
Year: 2013
Subjects: Oncology
Public health

description: Background: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes.
Methods: Twenty-seven SNPs in VHL, HGF, IL18, PRKACB, ABCB1, CYP2C8, ERCC2, and ERCC1 previously associated with ovarian cancer outcome were genotyped in 10,084 invasive cases from 28 studies from the Ovarian Cancer Association Consortium with over 37,000-observed person-years and 4,478 deaths. Cox proportional hazards models were used to examine the association between candidate SNPs and ovarian cancer recurrence or survival with and without adjustment for key covariates.
Results: We observed no association between genotype and ovarian cancer recurrence or survival for any of the SNPs examined.
Conclusions: These results refute prior associations between these SNPs and ovarian cancer outcome and underscore the importance of maximally powered genetic association studies.
Impact: These variants should not be used in prognostic models. Alternate approaches to uncovering inherited prognostic factors, if they exist, are needed.