cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Expression of the beta-hexosaminidase alpha subunit gene with the four-base insertion of infantile Jewish Tay-Sachs disease.
Creators: name: NANBA, E
name: TANAKA, A
name: SUZUKI, K
name: NISHIMOTO, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: One of the two mutations responsible for the classical infantile Jewish form of Tay-Sachs disease is a four-base insertion in exon 11 of the beta-hexosaminidase alpha subunit gene. The gene is known to be transcribed normally, but the mRNA is essentially undetectable. It is not clear why such a relatively minor abnormality results in complete failure to generate stable mRNA. The four-base insertion was introduced into the normal beta-hexosaminidase cDNA by site-directed mutagenesis. When COS-1 cells were transfected with the resultant mutant cDNA, it generated stable mRNA and a truncated, relatively stable but catalytically inactive enzyme protein. The mutant enzyme protein was not processed nor released into the culture medium. The mutant cDNA also generated the truncated enzyme protein in an in vitro translation system with rabbit reticulocyte lysate. COS-1 cells transfected with a 3' end of the gene segment, from intron 8 through the 3' terminus, generated processed RNA of approximately 2 kilobases, the size expected from normal splicing, irrespective of presence or absence of the four-base insertion in exon 11. These results indicate that the four-base insertion does not destabilize properly spliced mRNA, nor does it interfere with normal splicing of the transcript, at least in the expression system utilized. If the four-base insertion is responsible for the undetectable mRNA in the mutant cells, it must interfere with some other steps in the processing/splicing/transport of the primary transcript yet to be examined. On the other hand, the possibility cannot be excluded definitively that another still unidentified abnormality in the same allele might be responsible for the nearly complete absence of mRNA.
Pheidole mamore Wilson, 2003, new status
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole mamore

description: Pheidole mamore Mann, new status
Pheidole guilelmimuelleri subsp. mamore Mann 1916: 429.
Types Mus. Comp. Zool. Harvard.
Etymology Named after the type locality.
diagnosis Distinguished among members of the scrobifera group (as well as the somewhat similar antillana, avia, bucculenta, guilelmimuelleri, hetschkoi, heyeri, hortonae, praeses, and rhytifera in the tristis group) as follows.
Major: rugoreticulum on head limited to a patch posterior to each eye and another inside the anterior part of each antennal scrobe; anterior strip of pronotal dorsum transversely carinulate, the remainder rugoreticulate; mesonotal convexity subangulate in side view. Minor: propodeal spines reduced to denticles; entire body smooth and shining, with the sole sculpturing being the circular carinulae around the antennal fossae.
Measurements (mm) Lectotype major: HW 1.64, HL 1.64, SL 0.74, EL 0.20, PW 0.90. Paralectotype minor: HW 0.60, HL 0.64, SL 0.68, EL 0.14, PW 0.38. color Major: medium to dark reddish brown, appendages light reddish brown. Minor: body plain medium ("chocolate") brown, appendages medium brownish yellow.
Range In addition to the types, I have seen material from around Manaus, Amazonas, Brazil; near Puerto Maldonado, Leticia, and Tingo Maria, Peru; Suriname; and Guyana.
Biology Stefan Cover and John E. Tobin found this species on the floor of forest transitional from terra firme to floodplain at Cuzco Amazonico, near Puerto Maldonado, Peru. I encountered it in primary rainforest near Manaus. Colonies nest in pieces of rotten wood on the forest floor.
Figure Upper: lectotype, major. Lower: paralectotype, minor. BRAZIL: Madeira-Mamore railway track, km 284, Rondonia (W. M. Mann). Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 627
Differential cellular contractility as a mechanism for stiffness sensing
Creators: name: Dunlop, Carina M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cell Behavior (q-bio.CB)
subject: FOS: Biological sciences

description: The ability of cells to sense and respond to the mechanical properties of their environments is fundamental to a range of cellular behaviours, with substrate stiffness increasingly being found to be a key signalling factor. Although active contractility of the cytoskeleton is clearly necessary for stiffness sensing in cells, the physical mechanisms connecting contractility with mechanosensing and molecular conformational change are not well understood. Here we present a contractility-driven mechanism for linking changes in substrate stiffness with internal conformational changes. Cellular contractility is often assumed to imply an associated compressive strain. We show, however, that where the contractility is non-uniform, localized areas of internal stretch can be generated as stiffer substrates are encountered. This suggests a physical mechanism for the stretch-activation of mechanotransductive molecules on stiffer substrates. Importantly, the areas of internal stretch are not co-localized with those traditionally associated with stiffness sensing, e.g. focal adhesions, supporting recent experimental results on whole-cell mechanically-driven mechanotransduction. Considering cellular shape we show that aspect ratio acts as an additional control parameter, so that the onset of positive strain moves to higher stiffness values in elliptical cells.
Expression, isolation, and characterization of an active site (serine 528----alanine) mutant of recombinant bovine prothrombin.
Creators: name: Fowlkes, D M
name: Emfinger, S M
name: Baker, K
name: Pei, G
name: Lentz, B R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: An active site mutant bovine prothrombin cDNA (Ser528----Ala) has been constructed, subcloned, and expressed in Chinese hamster ovary cells. The recombinant mutant prothrombin, expressed at the level of 1.5-2.0 micrograms/ml of cell medium, was fully carboxylated (9.9 +/- 0.4 mol of gamma-carboxyglutamic acid/mol of prothrombin). The mutant prothrombin could be activated to thrombin by Taipan snake venom and activated to meizothrombin by ecarin in a manner comparable to native bovine prothrombin or recombinant wild-type bovine prothrombin. The mutant meizothrombin thus formed was stable and did not autolyze. The initial rate of cleavage of mutant prothrombin catalyzed by the full prothrombinase was only 28% of the rate of cleavage of native prothrombin, while recombinant wild-type prothrombin was cleaved at the same rate as the native molecule. The mutant thrombin, obtained from the mutant prothrombin in situ by prothrombinase or Taipan snake venom activation, showed no enzymatic activity toward either fibrinogen or a synthetic chromogenic substrate, D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroanilide dihydrochloride (S2238). The mutant thrombin also bound dansylarginine-N-(3-ethyl-1,5-pentanediyl)amide, a specific fluorescent inhibitor of the thrombin active site, with a weaker binding affinity (kd = 5.4 x 10(-8) M) than did native thrombin (kd = 1.7 x 10(-8) M). These results indicate that the mutant recombinant prothrombin described here is a useful tool for the study of meizothrombin or thrombin without the complications arising from the proteolytic activities of these molecules. Study of the activation of this mutant has already revealed a functional link between the site of initial cleavage by the prothrombinase and the conformation at the nascent active site of prothrombin.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0030v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0030v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0030v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Non self-adjoint operators with real spectra and extensions of quantum mechanics
Creators: name: Bebiano, N.
name: da Providência, J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this article, we review the general quantum mechanical setting associated to a non self-adjoint Hamiltonian with real spectrum. Spectral properties of the Hamiltonian of a simple model of the Swanson type are investigated. The eigenfunctions associated to the real simple eigenvalues are shown to form complete systems but not a (Riesz) basis, which gives rise to difficulties in the rigorous mathematical formulation of quantum mechanics. A new inner product, which is appropriate for the physical interpretation of the model, has been consistently introduced. The dynamics of the system is described. Some specificities of the theory of non self-adjoint operators with implications in quantum mechanics are discussed.
PSSOH workshop: Symbolic circuit analysis on Android
Creators: name: Tošić V., Dejan
name: Potrebić M., Milka
Publisher: name: Zenodo
Year: 2019
Subjects: symbolic analysis
electrical circuit
Android OS
Maxima

description: SRPSKI JEZIK Post-konferencijska PSSOH radionica na temu simboličke analize električnih kola u Android operativnom sistemu je održana 2. novembra 2019. godine na Univerzitetu u Beogradu - Elektrotehničkom fakultetu u sali 57. Zvanični naziv radionice na srpskom jeziku je "Simbolička analiza električnih kola na Androidu". Analiza električnih kola je realizovana u SALECx softveru koji je predstavljen u PSSOH radu: Tošić V., Dejan, & Potrebić M., Milka. (2019). Symbolic analysis of linear electric circuits with Maxima CAS (Version paper & presentation) (pp. 15–18). Belgrade, Serbia: University of Belgrade - School of Electrical Engineering and Academic Mind. http://doi.org/10.5281/zenodo.3533544. Kod je dostupan na https://github.com/pssoh/SALECx. PSSOH 2019 konferencija je uključila tri post-konferencijske radionice koje su održane 2. novembra 2019. godine: Radionica uređivanja Vikipedije, koju su pripremili I. Madžarević i N. Ratković Simbolička analiza električnih kola na Androidu koju su pripremili prof. D. V. Tošić i prof. M. M. Potrebić Implementacija i korišćenje otvorenih istraživačkih podataka za istraživače koju su pripremili N. Miljković, Lj. B. Lazarević, O. Vučkovac, i M. Ševkušić Zbornik radova sa PSSOH 2019 konferencije je dostupan na http://pssoh.etf.bg.ac.rs/img/PSSOH%20Proceedings%202019.pdf. ENGLISH LANGUAGE Post-conferece PSSOH workshop on symbolic circuit analysis on Android OS was held on November 2, 2019 at the University of Belgrade - School of Electrical Engineering in room 57. The workshop title in English is "Symbolic circuit analysis on Android". Circuit analysis is presented in SALECx software that has been described in PSSOH paper: Tošić V., Dejan, & Potrebić M., Milka. (2019). Symbolic analysis of linear electric circuits with Maxima CAS (Version paper & presentation) (pp. 15–18). Belgrade, Serbia: University of Belgrade - School of Electrical Engineering and Academic Mind. http://doi.org/10.5281/zenodo.3533544. Code is available at https://github.com/pssoh/SALECx. PSSOH 2019 conference included three post-conference workshops held on November 2, 2019: Wikipedia editing workshop by I. Madžarević and N. Ratković Symbolic circuit analysis on Android by D. V. Tošić and M. M. Potrebić Open research data practices for researchers by N. Miljković, Lj. B. Lazarević, O. Vučkovac, and M. Ševkušić Proceedings for the PSSOH 2019 conference is available at http://pssoh.etf.bg.ac.rs/img/PSSOH%20Proceedings%202019.pdf.
description: This record contains Call for workshop in both English and Serbian. The workshop was held in Serbian. Photo of the building of Technical faculties (where PSSOH 2019 will take place) was taken by Assist. Prof. Miodrag Tasić, PhD from University of Belgrade - School of Electrical Engineering, Belgrade, Serbia.
A relativistic dynamical model for pi-N scattering
Creators: name: Pascalutsa, V.
name: Tjon, J. A.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a unitary relativistic quasi-potential model for describing the low-energy pion-nucleon interaction, based on the equal time Bethe-Salpeter equation. It preserves the covariant structure of a relativistic spin 1/2 particle for the nucleon propagator, to be contrasted to other quasi-potential approximations.
description: 4 pages, Latex2e. To appear in the Proceedings of XV Int. Conf. on Few-Body Problems in Physics (Groningen, July 1997)
Pheidole peckorum Wilson, 2003, new species
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole peckorum

description: Pheidole peckorum new species
Types Mus. Comp. Zool. Harvard.
Etymology Named in honor of the collectors, both distinguished entomologists and field researchers.
diagnosis A strikingly unique species within the scrobifera group and Pheidole in general.
Major: anterior two-thirds of the dorsal head surface covered by a dense felt of very short, exactly erect hairs of uniform length; antennal scrobe deep, extending posteriorly past the transverse midline of the head and devoid of sculpturing; head rectangular in fullface view, and all of the anterior three-fourths except the central piece of the clypeus and frontal triangle rugoreticulate. Minor: all of the anterior five-sixths of the head capsule dorsum, including the frontal lobes, rugoreticulate; humerus right-angular in dorsal-oblique view; propodeal spines very long.
Measurements (mm) Holotype major: HW 1.04, HL 1.26, SL 0.50, EL 0.12, PW 0.60. Paratype minor: HW 0.54, HL 0.56, SL 0.50, EL 0.06, PW 0.34.
Color Major: body medium reddish brown except gaster which is light brown, appendages yellow. Minor: concolorous reddish yellow.
Range Known only from the type locality.
Biology Unknown.
Figure Upper: holotype, major (22 km southwest of Puyo, Pastaza, Ecuador). Lower: paratype, minor (tentatively associated with holotype major; 25 km north of Puyo, Pastaza, Ecuador, 1000 m). (Stewart B. Peck and Jarmila Kukalova-Peck.) Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 628
Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells
Creators: name: Reed, Eddie
name: Sancar, Aziz
name: Bohr, Vilhelm
name: Jones, Jennifer
name: Zhen, WP
name: Parker, Ricardo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: We have used three methods to study the formation and repair of intrastrand adducts and interstrand cross-links in the DNA of Chinese hamster ovary cells induced by the anticancer drug cis-diamminedichloroplatinum II (cisplatin). Using atomic absorption spectroscopy, we found that 21% of the total genomic cisplatin adducts were removed at 8 h and 42% at 24 h. We used ABC excinuclease digestion, coupled with out previously reported methodology to quantify DNA in specific genomic regions. These adducts were removed faster in the transcribed dihydrofolate reductase and c-myc genes compared to a noncoding fragment, a region containing the little or nontranscribed c-fos oncogene, and to the overall genome. Interstrand cross-links in specific sequences were quantified by Southern hybridization of denatured-renatured DNA separated on a neutral gel. We found that cross-links were removed more efficiently from the gene regions than intrastrand adducts and, at high levels of cross-linking, removal was similar from transcribed and from nontranscribed regions.
Minimal covers of hypergraphs
Creators: name: Banakh, Taras
name: van der Zypen, Dominic
Publisher: name: arXiv
Year: 2018
Subjects: subject: Combinatorics (math.CO)
subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 05C65, 05C70

description: For a hypergraph $H=(V,\mathcal E)$, a subfamily $\mathcal C\subseteq \mathcal E$ is called a cover of the hypergraph if $\bigcup\mathcal C=\bigcup\mathcal E$. A cover $\mathcal C$ is called minimal if each cover $\mathcal D\subseteq\mathcal C$ of the hypergraph $H$ coincides with $\mathcal C$. We prove that for a hypergraph $H$ the following conditions are equivalent: (i) each countable subhypergraph of $H$ has a minimal cover; (ii) each non-empty subhypergraph of $H$ has a maximal edge; (iii) $H$ contains no isomorphic copy of the hypergraph $(ω,ω)$. This characterization implies that a countable hypergraph $(V,\mathcal E)$ has a minimal cover if every infinite set $I\subseteq V$ contains a finite subset $F\subseteq I$ such that the family of edges $\mathcal E_F:=\{E\in\mathcal E:F\subseteq E\}$ is finite. Also we prove that a hypergraph $(V,\mathcal E)$ has a minimal cover if $\sup\{|E|:E\in\mathcal E\}
description: 5 pages
Verifying OpenJDK's LinkedList using KeY: Proof Files
Creators: name: Hiep, Hans-Dieter A.
name: Maathuis, Olaf
name: Jinting Bian
name: Boer, Frank S. De
name: Eekelen, Marko Van
name: Gouw, Stijn De
Publisher: name: Zenodo
Year: 2019
Subjects: formal methods
deductive verification
KeY project
Java Modeling Language
java.util.LinkedList

description: This archive contains a formal specification of Java's linked list. The archive contains an annotated version of java.util.LinkedList using the Java Modeling Language. Additionally, it includes the KeY version used to formally verify the annotated methods, and the corresponding proof files. The OpenJDK8 version can be found here: https://hg.openjdk.java.net/jdk8/jdk8/jdk/file/687fd7c7986d/src/share/classes/java/util/LinkedList.java
Identification of the membrane-embedded regions of the Neurospora crassa plasma membrane H (+)-ATPase.
Creators: name: Hennessey, J P
name: Rao, U S
name: Scarborough, G A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Reconstituted proteoliposomes containing functional Neurospora crassa plasma membrane H(+)-ATPase molecules oriented predominantly with their cytoplasmic surface exposed were treated with trypsin and then subjected to Sepharose CL-6B column chromatography to remove the liberated peptides. The peptides remaining associated with the liposomes were then separated from the phospholipid by Sephadex LH-60 column chromatography and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Six H(+)-ATPase peptides with approximate molecular masses of 7, 7.5, 8, 10, 14, and 21 kDa were found to be tightly associated with the liposomal membrane. Amino acid sequencing of the 7-, 7.5-, and 21-kDa peptides in the LH-60 eluate identified them as H(+)-ATPase fragments beginning at residues 99 or 100, 272, and 660, respectively. After further purification, the approximately 10- and 14-kDa peptides were also similarly identified as beginning at residues 272 and 660. The approximately 8-kDa fragment was purified further but could not be sequenced, presumably indicating NH2-terminal blockage. To identify which of the liposome-associated peptides are embedded in the membrane, H(+)-ATPase molecules in the proteoliposomes were labeled from the hydrophobic membrane interior with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine and cleaved with trypsin, after which the membrane-associated peptides were purified and assessed for the presence of label. The results indicate that the approximately 7-, 7.5-, and 21-kDa peptides are in contact with the lipid bilayer whereas the approximately 8-kDa peptide is not. Taken together with the results of our recent analyses of the peptides released from the proteoliposomes, this information establishes the transmembrane topography of nearly all of the 919 residues in the H(+)-ATPase molecule.
Pheidole scrobifera Emery
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole scrobifera

description: Pheidole scrobifera Emery
Pheidole scrobifera Emery 1896g: 73.
Types Mus. Civ. Stor. Nat. Genova.
etymology L scrobifera, trench-bearer, alluding to the antennal scrobes.
diagnosis Distinguished from other members of the scrobifera group as follows.
Major: pilosity very short, absent on anterior half of dorsal profile of head and present as uniform, suberect hairs along the posterior half of the profile; entire dorsal head surface posterior to the eyes rugoreticulate; promesonotal sculpturing consisting entirely of foveolation; petiolar and postpetiolar nodes entirely smooth and shiny; head capsule with bilateral dark spots. Minor: humerus cornulate; propodeal spines long and slender; dorsal head surface and all of mesosoma foveolate, with no carinulae or rugulae anywhere on the body.
Measurements (mm) Major (La Selva Biological Station, Costa Rica): HW 0.88, HL 1.08, SL 0.42, EL 0.14, PW 0.54. Minor (La Selva Biological Station): HW 0.44, HL 0.46, SL 0.36, EL 0.10, PW 0.30.
Color Major: head and mandibles light reddish brown, with bilateral dark brown spots on the dorsal surface, as illustrated; mesosoma a slightly lighter shade of light reddish brown; waist, gaster, legs, and antennae brownish yellow. Minor: head and mesosoma dark, slightly reddish yellow; appendages clear medium yellow.
Range Atlantic slope of Costa Rica to 900 m (J. T. Longino 1997).
Biology According to Longino (1997), as well as Stefan Cover and James C. Trager (independent field notes), scrobifera is relatively common in mature wet forest, nesting in rotten logs and other pieces of rotten wood on the forest floor. Workers have been observed foraging at night.
Figure Upper: major (right hind femur shown at bottom). Lower: minor. COSTA RICA: La Selva Biological Station, near Puerto Viejo (Stefan Cover). (Type locality: Jimenez, near Guapiles, Costa Rica.) Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 629
Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes: NUC18 is not histone H2B
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Glucocorticoids stimulate apoptosis in rat thymocytes that is characterized by internucleosomal DNA degradation. We have previously identified an 18-kDa calcium-dependent nuclease whose activity is associated with this DNA degradation. The existence of this nuclease has been challenged by Alnemri and Litwack (1989) J. Biol. Chem. 264, 4104-4111, who suggest that the nuclease we observed was histone H2B. We report here a modified nuclease assay which uses [32P] DNA as a substrate that has enabled the purification and characterization of the 18-kDa nuclease (NUC18). Using Bio-Rex 70 chromatography in conjunction with this assay, we show that NUC18 can be separated from histone H2B. Enzymatically active NUC18, purified to apparent homogeneity, failed to react with two different anti-histone H2B antibodies. NUC18 was inactive in the absence of calcium and known inhibitors of apoptosis, i.e. zinc and aurintricarboxylic acid inhibit its activity. Although NUC18 activity was detected in nuclear extracts of thymocytes of both control and glucocorticoid-treated thymocytes, these activities were distinct. Gel filtration analysis revealed that NUC18 was present as a high molecular weight complex (greater than 100 kDa) in both groups of cells, whereas it also existed as a low molecular weight form in glucocorticoid-treated cells. Thus, NUC18 remains a candidate for the endonuclease responsible for the DNA degradation component of the apoptotic process.
Additional file 1: of The association between living alone and health care utilisation in older adults: a retrospective cohort study of electronic health records from a London general practice
Creators: name: Dreyer, Kathryn
name: Steventon, Adam
name: Fisher, Rebecca
name: Deeny, Sarah
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Table S1. Utilisation by utilisation, count (percentage %). This table sets out a count of patients by utilisation and demonstrates the relationship between utilisation of different health care services (DOCX 22 kb)
100% open collaborative research for climate change knowledge
Creators: name: Murray-Rust, Peter
name: Worthington, Simon
Publisher: name: Zenodo
Year: 2019
Subjects: climate change
open science
open access
data mining

description: Introduction of the Open Climate Knowledge project for a panel on Open Science Publishing Flood and Collaborative Authoring for the conference Twenty-First International Conference on Grey Literature: Open Science Encompasses New Forms of Grey Literature
description: {"references": ["https://doi.org/10.25815/eb9f-ad48", "https://doi.org/10/gf64mq"]}
Reasoning on Adopting OPC UA for an IoT-Enhanced Smart Energy System from a Security Perspective
Creators: name: Marksteiner, Stefan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Smart Services using Industrial Internet of Things (IIoT) applications are on the rise, but still more often than not, traditional industrial protocols are used to interconnect the entities of the resulting systems. These protocols are mostly not intended for functioning in such a highly interconnected environment and, therefore, often lack even the most fundamental security measures. To address this issue, this paper reasons on the security of a communications protocol, intended for Machine to machine (M2M) communications, namely the Open Platform Communications Unified Architecture (OPC UA) and exemplifies, on a smart energy system, its capability to serve as a secure communications architecture by either itself or in conjunction with traditional protocols.
description: 4 pages, 1 figure, This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 773715, Proceedings of the 2018 IEEE 20th Conference on Business Informatics (CBI)
Pheidole simonsi Wilson, 2003, new species
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole simonsi

description: Pheidole simonsi new species
Types Mus. Comp. Zool. Harvard.
Etymology Named in honor of my friend, the late Howard Simon, former managing editor of the Washington Post, Curator of the Nieman Fellows, and fellow entomologist.
diagnosis Distinguished within Pheidole generally by the following set of character states.
Major: scrobes extend halfway up the head capsule; entire rear third of head dorsum, including occiput, rugoreticulate, but central third devoid of any sculpturing except scattered foveolae; postpetiolar node rugoreticulate; ventral profile of first gastral tergite lined with dense semierect hairs of uniform length.
Minor: propodeal spines very long, thin, and needle-like; body almost completely devoid of any sculpturing, instead smooth and shiny everywhere. The minor is very close to thrasys, differing in the slightly broader occiput, rudimentary nuchal collar, and brown tarsi.
Measurements (mm) Holotype major: HW 1.34, HL 1.60, SL 0.58, EL 0.14, PW 0.78. Paratype minor: HW 0.66, HL 0.70, SL 0.66, EL 0.14, PW 0.44.
Color Major: head and mesosoma medium reddish brown, waist and mandibles plain dark brown, gaster black, antennae and legs medium brown.
Minor: head, waist, gaster, and femora dark, almost blackish brown; mandibles, mesosoma, and rest of leg segments medium brown.
Range Both Atlantic and Pacific slopes of Costa Rica to 800 m (J. T. Longino 1997).
Biology J. T. Longino (1997): "This species occurs in mature moist to wet forest. It nests in the soil, with a main nest chamber about 10 cm deep. When workers excavate soil from the nest, they often form a characteristic flat arena around the nest entrance, surrounded by a palisade-like ring of soil. Their nests contain seed caches, and the majors have massive heads, which suggest granivory as a major component of the diet. They are not restricted to granivory, however, since workers readily recruit to baits of several kinds." I found simonsi nests of the kind just described in bare stretches of clay-soil paths through mature forest at the La Selva Biological Station.
figure Upper: holotype, major. Lower: paratype, minor. COSTA RICA: La Selva Biological Station, near Puerto Viejo, Heredia (Stefan Cover). Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 630
The decay tau -> 3 pi + nu(tau) as a probe of the mechanism of dynamical chiral symmetry breaking
Creators: name: Girlanda, Luca
name: Stern, Jan
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The decays tau -> 3 pi + nu(tau) are analyzed at one loop order in the framework of Generalized Chiral Perturbation Theory, in order to test the sensitivity to the size of spontaneous chiral symmetry breaking parameters, contained in the S-wave. The latter, due to a kinematical suppression, at threshold, of the P-wave, is relatively large enough to be detectable at high energy machines, through azimuthal left-right asymmetries. This quantity (for the pi- pi- pi+ mode), integrated from threshold to Q^2 = 0.35 GeV^2, varies from (17 +- 3) % in the standard case of large condensate up to (40 +- 5) % in the extreme case of tiny condensate. The feasibility of such measurement at high luminosity colliders (e.g. CLEO) is discussed. This method provides a completely independent cross-check of forthcoming experimental determination of the quark condensate, based on low energy pi-pi scattering.
description: 29 pages, Latex, using JHEP.cls (included), 7 PS figures
Pheidole thrasys Wilson, 2003, new species
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole thrasys

description: Pheidole thrasys new species
Types Mus. Comp. Zool. Harvard.
Etymology Gr thrasys, bold, courageous.
Diagnosis A member of the scrobifera group known only from the minor, close to arctos of northeastern Mexico and epetrion of Ecuador, differing in the narrowed occiput, possession of a nuchal collar, and completely smooth and shiny mesonotum; also close to simonsi, differing in its narrower occiput, well-developed nuchal collar, and yellow tarsi.
Measurements (mm) Holotype minor: HW 0.60, HL 0.62, SL 0.60, EL 0.12, PW 0.40.
Color Minor: body dark brown, tarsi yellow, rest of appendages light yellow.
Range Known only from the type locality, and from Lancetilla, near Tela, Honduras (W. L. Brown).
Biology The Honduras series was collected in wet lowland forest.
Figure Holotype, minor. PANAMA: Barro Colorado Island (William L. Brown and Elwood S. McCluskey). Scale bar = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 631
Additional file 2: of Response rates in patients with schizophrenia and positive symptoms receiving cognitive behavioural therapy: a systematic review and single-group meta-analysis
Creators: name: Bighelli, Irene
name: Huhn, Maximilian
name: Schneider-Thoma, Johannes
name: Krause, Marc
name: Reitmeir, Cornelia
name: Wallis, Sofia
name: Schwermann, Felicitas
name: Pitschel-Walz, Gabi
name: Barbui, Corrado
name: Toshi Furukawa
name: Leucht, Stefan
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Risk of bias assessment (PDF 766 kb)
Initiation of protein synthesis in animal mitochondria : purification and characterization of translational initiation factor 2
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Bovine liver mitochondrial translational initiation factor 2 (IF-2mt) has been purified to near homogeneity. The scheme developed results in a 24,000-fold purification of the factor with about 26% recovery of activity. SDS-polyacrylamide gel electrophoresis indicates that IF-2mt has a subunit molecular mass of 85 kDa. IF-2mt promotes the binding of formyl(f)Met-tRNA to mitochondrial ribosomes but is inactive with the nonformylated derivative. IF-2mt is active on chloroplast 30 S ribosomal subunits, but IF-2chl has no activity in promoting fMet-tRNA binding to animal mitochondrial ribosomes. IF-2mt is sensitive to elevated temperatures and is inactivated by treatment with N-ethylmaleimide. It is partially protected from heat and N-ethylmaleimide inactivation by the presence of either GTP or GDP suggesting that guanine nucleotides may bind to this factor directly. The binding of fMet-tRNA to mitochondrial ribosomes requires the presence of GTP and is inhibited by GDP. DeoxyGTP is very effective in replacing GTP in promoting fMet-tRNA binding to ribosomes and some activity is also observed with ITP. No activity is observed with ATP, CTP, or UTP. Nonhydrolyzable analogs of GTP can promote formation of both 28 S and 55 S initiation complexes indicating that GTP hydrolysis is not required for subunit joining in the animal mitochondrial system.
Pheidole tisiphone Wheeler
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole tisiphone

description: Pheidole tisiphone Wheeler
Pheidole tisiphone Wheeler 191 lk: 203. Combination inpheidole (Elasmopheidole) by Emery 1915g: 190.
types Nat. Mus. Nat. Hist. U. S.
etymology Tisiphone, Avenger of Murders, one of the Furies of Greek mythology.
Diagnosis A large member of the scrobifera group, with a bizarre major instantly recognizable by shield-shaped head in full-face view, with the frontal lobes expanded laterally to touch the lateral margins of the head at the level of the eyes and behind it and extended anteriorly almost to touch the anterior clypeal border; by the very dense, long hairs covering the entire head, with those around the region of the eye curving posteriorly; and by the deep, narrow antennal scrobes. The mesonotum is rugoreticulate in the Guatemalan specimen, and mostly carinulate in the unique holotype, but otherwise the two specimens are very close. measurements (mm) Holotype major: HW 1.80, HL 2.16, SL 0.76, EL 0.20, PW 1.00. color Major: body light reddish brown, appendages light reddish to yellowish brown.
range Known only from the two major workers noted above, from Oaxaca, Mexico, and Guatemala.
biology Unknown.
figure Major. GUATEMALA: San Jose (E. S. Ross, in Mus. Comp. Zool. Harvard). Compared with unique holotype major, Almoloya, Oaxaca, Mexico, collected by Frederick Knab, in Nat. Mus. Nat. Hist U. S. Scale bar = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 632
title: "Réponses deuxièmes des investigateurs d’ICCARRE au compte-rendu de l’AC5 du 19 janvier 2011"
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 pièce
Interaction of peptides corresponding to mitochondrial presequences with membranes
Creators: name: Cyr, D M
name: Douglas, M G
name: Gierasch, L M
name: Hoyt, D W
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: The transport of the F1-ATPase beta-subunit precursor into mitochondria is dependent upon a presequence at its amino terminus. Within the mitochondrial membrane translocation site the potential amphiphilic character of the presequence region may be necessary to stabilize binding to the mitochondrial inner membrane. To better understand its role in protein import, the interaction of the F1 beta-presequence with lipid membranes was measured using circular dichroism and surface tensiometry. These studies reveal that a 20-residue peptide containing the F1 beta-presequence binds to phospholipid vesicles (Kd = 4.5-6.0 x 10(-8)M and adopts a predominantly alpha-helical structure. Although the presequence peptide binds avidly to lipids, it does not appear to penetrate deeply into the bilayer to perturb a reporter probe in the membrane interior. Compared with the effect of the peptides with demonstrated membrane insertion and lytic properties, the F1-beta-presequence appears to displace phospholipid head groups but not insert deeply into the bilayer. High concentrations (greater than 50 microM) of presequence peptides are required to noticibly perturb import of the full length F1 alpha- or F1 beta-subunit precursors. Thus, the F1 beta-presequence alone is not sufficient to efficiently compete for import but may require a protein context or a minimal length to assist insertion into the transport site. These observations are discussed in light of the different requirements for import of various presequence containing precursors into mitochondria.
Lateral diffusion of redox components in the mitochondrial inner membrane is unaffected by inner membrane folding and matrix density
Creators: name: Chazotte, B
name: Hackenbrock, C R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: We report the first lateral diffusion measurements of redox components in normal-sized, matrix-containing, intact mitoplasts (inner membrane-matrix particles). The diffusion measurements were obtained by submicron beam fluorescence recovery after photobleaching measurements of individual, intact, rat liver mitoplasts bathed in different osmolarity media to control the matrix density and the extent of inner membrane folding. The data reveal that neither the extent of mitochondrial matrix density nor the complexity of the inner membrane folding have a significant effect on the mobility of inner membrane redox components. Diffusion coefficients for Complex I (NADH:ubiquinone oxidoreductase), Complex III (ubiquinol: cytochrome c oxidoreductase), Complex IV (cytochrome oxidase), ubiquinone, and phospholipid were found to be effectively invariant with the matrix density and/or membrane folding and essentially the same as values we reported previously for spherical, fused, ultralarge, matrix-free, inner membranes. Diffusion of proton-transporting Complex V (ATP synthase) appeared to be 2-3-fold slower at the greatest matrix density and degree of membrane folding. Consistent with a diffusion-coupled mechanism of electron transport, comparison of electron transport frequencies (productive collisions) with the theoretical, diffusion-controlled, collision frequencies (maximum collisions possible) revealed that there were consistently more calculated than productive collisions for all redox partners. Theoretical analyses of parameters for submicron fluorescence recovery after photobleaching measurements in intact mitoplasts support the finding of highly mobile redox components diffusing at the same rates as determined in conventional fluorescence recovery after photobleaching measurements in fused, ultralarge inner membranes. These findings support the Random Collision Model of Mitochondrial Electron Transport at the level of the intact mitoplast and suggest a similar conclusion for the intact mitochondrion.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00557
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00557, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Supplement S1 to Grimm et al. 2004: Using the ODD protocol and NetLogo to replicate agent-based models:
Creators: name: Grimm, Volker
Publisher: name: Zenodo
Year: 2024

description: This is a supplement S1 to:

Grimm V, Berger U, Calabrese JM, Cortés-Avizanda A, Ferrer J, Franz M, Groeneveld J, Hartig F, Jakoby O, Jovani R, Kramer-Schadt S, Münkemüller T, Piou C, Premo LS, Pütz S, Quintaine T, Rademacher C, Rüger N, Schmolke A, Thiele JC, Touza J, Railsback SF. Using the ODD protocol and NetLogo to replicate agent-based models. Ecological Modelling - submitted R1, October 2024
Dynamic Light Scattering from Semidilute Actin Solutions: A Study of Hydrodynamic Screening, Filament Bending Stiffness and the Effect of Tropomyosin/Troponin-Binding
Creators: name: Goetter, R.
name: Kroy, K.
name: Frey, E.
name: Baermann, M.
name: Sackmann, E.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: Quasi-elastic light scattering (QELS) is applied to investigate the effect of the tropomyosin/troponin complex (Tm/Tn) on the stiffness of actin filaments. The importance of hydrodynamic screening in semidilute solutions is demonstrated. A new concentration dependent expression for the dynamic structure factor $g(\bm k,t)$ of semiflexible polymers in semidilute solutions is used to analyze the experimental QELS data. A concentration independent value for the bending modulus $κ$ is thus obtained. It increases by 50\% as a consequence of Tm/Tn binding in a 7:1:1 molar ratio of actin/Tm/Tn. In addition a new expression for the initial slope of the dynamic structure factor of a semiflexible polymer is used to determine the effective hydrodynamic diameter of the actin filament. Our results confirm the general relevance of the concept of (intrinsic) semiflexibility to polymer dynamics.
description: 9 pages, RevTeX, 9 figures, all uuencoded gziped
Limits on excited tau leptons masses from leptonic tau decays
Creators: name: Aranda, J. I.
name: Martinez, R.
name: Sampayo, O. A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the effects induced by excited leptons on the leptonic tau decay at one loop level. Using a general effective lagrangian approach to describe the couplings of the excited leptons, we compute their contributions to the leptonic decays and use the current experimental values of the branching ratios to put limits on the mass of excited states and the substructure scale.
description: 10 pages, 6 figures, to be published in Phys. Rev. D
Leukocyte chemoattractant peptides from the serpin heparin cofactor II
Creators: name: CHURCH, F.
name: HOFFMAN, M
name: PRATT, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Heparin cofactor II (HC) is a plasma serine proteinase inhibitor (serpin) that inhibits the coagulant proteinase alpha-thrombin. We have recently demonstrated that proteolysis of HC by catalytic amounts of polymorphonuclear leukocyte proteinases (elastase or cathepsin G) generates leukocyte chemotaxins (Hoffman, M., Pratt, C. W., Brown, R. L., and Church, F. C. (1989) Blood 73, 1682-1685). One of four peptides produced when HC is degraded by neutrophil elastase has chemotactic activity for both monocytes and neutrophils with maximal migration comparable to formyl-Met-Leu-Phe, the "gold standard" bacterially derived chemotaxin. The amino-terminal sequence of this HC peptide is Asp-Phe-His-Lys-Glu-Asn-Thr-Val-... and the peptide corresponds to Asp-39 to Ile-66 of HC. A variety of synthetic peptides derived from this sequence were evaluated for leukocyte migration activity, and a dodecapeptide from Asp-49 to Tyr-60 (Asp-Trp-Ile-Pro-Glu-Gly-Glu-Glu-Asp-Asp-Asp-Tyr) was identified as the active site for leukocyte chemotactic action. The 12-mer synthetic peptide possesses significant neutrophil chemotactic action at 1 nM (60% of the maximal activity of formyl-Met-Leu-Phe), while a peptide with the reverse sequence has essentially no chemotactic activity. Cross-desensitization experiments also show that pretreatment of neutrophils with a 19-mer peptide (Asn-48 to Ile-66) greatly reduces subsequent chemotaxis to HC-neutrophil elastase proteolysis reaction products. When injected intraperitoneally in mice, the HC-neutrophil elastase digest elicits neutrophil migration. Our results demonstrate that not only does HC function as a thrombin inhibitor, but that limited proteolysis of HC near the amino terminus yields biologically active peptide(s) which might participate in inflammation and in wound healing and tissue repair processes.