cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structure Based Substrate Specificity Analysis of Heparan Sulfate 6- O -Sulfotransferases
Creators: name: Liu, Jian
name: Pedersen, Lars C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Heparan sulfate (HS) is a sulfated polysaccharide exhibiting essential physiological functions. HS 6-O-sulfotransferase (6-OST) transfers a sulfo group to the 6-OH position of glucosamine units to confer a variety of HS biological activities. There are three different isoforms of 6-OST in the human genome. Here, we report crystal structures of the ternary complex of 6-OST with the sulfo donor analog 3′-phosphoadenosine 5′-phosphate and three different oligosaccharide substrates at 1.95 to 2.1 Å resolutions. Structural and mutational analyses reveal amino acid residues that contribute to catalysis and substrate recognition of 6-OST. Unexpectedly, the structures reveal 6-OST engages HS in a completely different orientation than other HS sulfotransferases, and sheds light on the basic HS requirements for specificity. These findings also contribute structural information to understand mutations in human 6-OST isoform 1 associated with the human genetic disease idiopathic hypogonadotrophic hypogonadism characterized by delayed or lack of puberty.
Humans, livestock, and lions in northwest Namibia
Creators: name: Heydinger, John Moore
Publisher: name: Macquarie University
Year: 2023
Subjects: classificationCode: 399999
subject: Other education not elsewhere classified

description: Humans, livestock, and lions have inhabited shared landscapes in northwest Namibia for hundreds of years. Currently, human-lion conflict (HLC) threatens pastoral livelihoods and the viability of the region's desert-adapted lion population. In this dissertation I examine the history of human-livestock-lion relationships in the region. The goal is to create historically-informed solutions to HLC that are locally-inclusive. Drawing on archival, scientific, and governmental material, as well as social surveys and oral histories that I have performed, this is the first time that the disparate sources on human-livestock-lion relationships in northwest Namibia have been unified. While scholars of African environments have problematized interpretations of Africa's environmental colonial and postcolonial past, this is the first work to examine human-predator relationships as a fulcrum for understanding colonial and postcolonial politics and the current challenges of conserving African lions. As a document informing ongoing conservation interventions, this is the first attempt to explicitly frame applied lion conservation activities within historical contexts, critically assessing livestock as mediators of human-lion interactions. I begin by showing how the precolonial and early-colonial experience of the region's ovaHerero people was mediated through the control of livestock. I then examine how colonial era policies remade, and were aided by, the geography of predators. The effects of apartheid on the region's wildlife showcase some of the important legacies of colonial-era policies. I then reveal the long history of human-lion interactions with particular emphasis on the transformative role of livestock. I then focus on the behavior and ecology of the desert-adapted lions, highlighting important contrasts with other lion populations and emphasizing how recent monitoring induced a paradigm shift. Finally, I center ongoing HLC within communal rangelands as experienced by pastoralists and suggest one way of reframing HLC that is founded in local perspectives.
title: 5.-8. April 2022
Creators: name: Beckert, Bernhard
name: Budurushi, Jurlind
name: Grunwald, Armin
name: Krimmer, Robert
name: Kulyk, Oksana
name: Küsters, Ralf
name: Mayer, Andreas
name: Müller-Quade, Jörn
name: Neumann, Stephan
name: Volkamer, Melanie
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022

description: The paper summarizes the technical report [Be21] which was published in 2021. The aim of the paper is to summarize and critically discuss the situation in Germany concerning electronic voting.
title: Reachability in Two-Parametric Timed Automata with one Parameter is EXPSPACE-Complete
Creators: name: Göller, Stefan
name: Hilaire, Mathieu
Publisher: name: Universität Kassel
Year: 2023
Subjects: subject: Parametric timed automata
subject: Computational complexity
subject: Reachability
subject: EXPSPACE-complete
subject: 004
subject: 620
subject: Informatik
subject: Zeitsteuerung
subject: Automat

description: Gefördert im Rahmen des Projekts DEAL
Dopamine Dynamics during Continuous Intracranial Self-Stimulation: Effect of Waveform on Fast-Scan Cyclic Voltammetry Data
Creators: name: Johnson, Justin A.
name: Bucher, Elizabeth S.
name: Wightman, R. Mark
name: Rodeberg, Nathan T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The neurotransmitter dopamine is heavily implicated in intracranial self-stimulation (ICSS). Many drugs of abuse that affect ICSS behavior target the dopaminergic system, and optogenetic activation of dopamine neurons is sufficient to support self-stimulation. However, the patterns of phasic dopamine release during ICSS remain unclear. Early ICSS studies using fast-scan cyclic voltammetry (FSCV) rarely observed phasic dopamine release, which led to the surprising conclusion that it is dissociated from ICSS. However, several advances in the sensitivity (i.e., the use of waveforms with extended anodic limits) and analysis (i.e., principal component regression) of FSCV measurements have made it possible to detect smaller, yet physiologically relevant, dopamine release events. Therefore, this study revisits phasic dopamine release during ICSS using these tools. It was found that the anodic limit of the voltammetric waveform has a substantial effect on the patterns of dopamine release observed during continuou...
Gapless quantum spin liquid ground state in the two-dimensional spin-1/2 triangular antiferromagnet YbMgGaO$_4$
Creators: name: Li, Yuesheng
name: Liao, Haijun
name: Zhang, Zhen
name: Li, Shiyan
name: Jin, Feng
name: Ling, Langsheng
name: Zhang, Lei
name: Zou, Youming
name: Pi, Li
name: Yang, Zhaorong
name: Wang, Junfeng
name: Wu, Zhonghua
name: Zhang, Qingming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Quantum spin liquid (QSL) is a novel state of matter which refuses the conventional spin freezing even at 0 K. Experimentally searching for the structurally perfect candidates is a big challenge in condensed matter physics. Here we report the successful synthesis of a new spin-1/2 triangular antiferromagnet YbMgGaO$_4$ with R$\bar{3}$m symmetry. The compound with an ideal two-dimensional and spatial isotropic magnetic triangular-lattice has no site-mixing magnetic defects and no antisymmetric Dzyaloshinsky-Moriya (DM) interactions. No spin freezing down to 60 mK (despite $Θ$$_w$ $\sim$ -4 K), the low-T power-law temperature dependence of heat capacity and nonzero susceptibility suggest that YbMgGaO$_4$ is a promising gapless ($\leq$ $|$$Θ$$_w$$|$/100) QSL candidate. The residual spin entropy, which is accurately determined with a non-magnetic reference LuMgGaO$_4$, approaches zero ($
description: 28 pages including supplementary materials, 4 figures, 33 references
Unmet Reproductive Health Care Needs and Occurrence of Unintended Pregnancy among HIV Positive Women in Antiretroviral Treatment Units in Addis Ababa, Ethiopia
Creators: name: Girum Zewudu
Publisher: name: Zenodo
Year: 2011

description: Back ground: Reproductive health issues appear to be relatively neglected among HIV positive women. Hence the contribution of contraception as a strategy to reduce mother-to-child transmission is underutilized. As well, there are few incites and substantive data on the magnitude of unmet reproductive health care needs and occurrence of unintended pregnancy among HIV positive women is not available in Ethiopia (Addis Ababa). Objective of the study: This study assessed unmet reproductive health care needs and occurrence of unintended pregnancy among HIV positive women enrolled in the ART units. Methodology: The study was undertaken from December 2010 to Feburary2011 using quantitative cross sectional facility based study supplemented by qualitative in-depth interview on a sample of 548 HIV positive women in the ART follow up units in Addis Ababa. A systematic random sampling procedure was applied to select study participants. A pretested structured questioner was used to collect data and the data was analyzed using SPSS version 11.
title: 5.-8. April 2022
Creators: name: Saatjohann, Christoph
name: Ising, Fabian
name: Gierlings, Matthias
name: Noss, Dominik
name: Schimmler, Sascha
name: Klemm, Alexander
name: Grundmann, Leif
name: Frosch, Tilman
name: Schinzel, Sebastian
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: DICOM||HL7||TLS||Netzwerksegmentierung||Scanning||Fuzzing||Telematikinfrastruktur

description: Medizinische Einrichtungen waren in den letzten Jahren immer wieder von Cyber-Angriffen betroffen. Auch wenn sich diese Angriffe derzeit auf die Office-IT-Infrastruktur der Einrichtungen konzentrieren, existiert mit medizinischen Systemen und Kommunikationsprotokollen eine weitere wenig beachtete Angriffsoberfläche. In diesem Beitrag analysieren wir die weit verbreiteten medizintechnischen Kommunikations-Protokolle DICOM und HL7 sowie Protokoll-Implementierungen auf ihre IT-Sicherheit. Dafür präsentieren wir die Ergebnisse der Sicherheitsanalyse der DICOM-und HL7-Standards, einen Fuzzer “MedFUZZ” für diese Protokolle sowie einen Schwachstellenscanner “MedVAS”, der Schwachstellen in medizintechnischen Produktivumgebungen auffinden kann.
Failure of Standard Training Sets in the Analysis of Fast-Scan Cyclic Voltammetry Data
Creators: name: Rodeberg, Nathan T.
name: Wightman, R. Mark
name: Johnson, Justin A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The use of principal component regression, a multivariate calibration method, in the analysis of in vivo fast-scan cyclic voltammetry data allows for separation of overlapping signal contributions, permitting evaluation of the temporal dynamics of multiple neurotransmitters simultaneously. To accomplish this, the technique relies on information about current-concentration relationships across the scan-potential window gained from analysis of training sets. The ability of the constructed models to resolve analytes depends critically on the quality of these data. Recently, the use of standard training sets obtained under conditions other than those of the experimental data collection (e.g., with different electrodes, animals, or equipment) has been reported. This study evaluates the analyte resolution capabilities of models constructed using this approach from both a theoretical and experimental viewpoint. A detailed discussion of the theory of principal component regression is provided to inform this discu...
title: 5.-8. April 2022
Creators: name: Jacob, Florian
name: Bayreuther, Saskia
name: Hartenstein, Hannes
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: Dependable Distributed Protocols||Conflict-Free Replicated Data Types||Equivocation Tolerance||Byzantine Fault Model||Matrix Event Graph

description: Conflict-free Replicated Data Types (CRDTs) allow updates to be applied to different replicas independently and concurrently, without the need for a remote conflict resolution. Thus, they provide a building block for scalability and performance of fault-tolerant distributed systems. Currently, CRDTs are typically used in a crash fault setting for global scale, partition-tolerant, highly available databases or collaborative applications. In this paper, we explore the use of CRDTs in Byzantine environments. This exploration is inspired by the popular Matrix messaging system: as recently shown, the underlying Matrix Event Graph replicated data type represents a CRDT that can very well deal with Byzantine behavior. This “Byzantine Tolerance” is due to mechanisms inherent in CRDTs and in the hash-based directed acyclic graph (HashDAG) data structure used in Matrix. These mechanisms restrict Byzantine behavior. We, therefore, discuss Byzantine behavior in a context of CRDTs, and how the notion of Byzantine tolerance relates to equivocation. We show that a subclass of CRDTs is equivocation-tolerant, i.e., without equivocation detection, prevention or remediation, this subclass still fulfills the CRDT properties, which leads to Byzantine tolerance. We conjecture that an operation-based Byzantine-tolerant CRDT design supporting non-commutative operations needs to be based on a HashDAG data structure. We close the paper with thoughts on chances and limits of this data type.
title: Empirical essays in economic geography and labour economics: regulations and the labour market consequences of automation and innovation
Creators: name: Yu, Jen-Hsuan (Paul)
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2022

description: This thesis is comprised of four distinct, original pieces of research on topics related to economic geography and the labour market consequences of innovation and automation. The first chapter outlines the thesis and sets the scene. The second chapter studies the determinants of the variation in the returns to college education across U.S. cities. We find that local innovation exerts a positive influence on local education returns and such effects are particularly pronounced in larger cities. Our findings have implications for within-city levels of inequality, particularly across the skill distribution. The next two chapters in the thesis relate to the role of automation technologies and their implications for labour markets, specifically concerning the recent arrival and widespread use of industrial robots in the production process. Hence, the third chapter examines the use of robots in the U.K. exploring trends across local labour markets. The study yields interesting findings in employment dynamics across occupations and industries that echo past studies. The fourth chapter assesses the role of the same technology in a cross-country setting with an emphasis on industry linkages. I find that greater rates of robot usage in one industry are positively associated with the labour market outcomes of downstream sectors. This effect is likely driven by price mechanisms when industries experience technological change that raise their productivity potential. The final chapter explores the local growth consequences of land use regulation in U.S. cities. I find that the composition of local growth outcomes can be influenced by the level of regulatory constraints on housing, particularly in high demand localities. I hope the findings and insights from this thesis can have the potential to possibly inform aspects of urban, innovation and/or labour market policies.
MIDUS 2 Neuroscience Project (Project 5) Baseline EEG Reprocessing
Creators: name: Finley, Anna
name: Angus, Douglas
name: van Reekum, Carien
name: Schaefer, Stacey
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Other Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: EEG
subject: MIDUS
subject: neuroscience
subject: social neuroscience

description: The Midlife in the United States study (MIDUS) is a longitudinal national study of adults in the United States that began in 1995. MIDUS consists of several projects, including Survey, Daily Diary, Cognitive, Biomarkers, and Neuroscience projects. The original MIDUS sample was assessed between 1995-1997 (MIDUS 1), again between 2004-2009 (MIDUS 2), and again starting in 2013 (data collection ongoing; MIDUS 3). To replenish the original sample, new participants were added to the protocol between 2011-2014 (MIDUS Refresher). This OSF page is intended to serve as the basis for several projects relating to the MIDUS 2 neuroscience project baseline EEG data. We outline here the details of how MIDUS 2 baseline EEG data were collected, cleaned, and processed by our group. Parts of the MIDUS Refresher EEG data have already been analyzed and made publicly available, and some hypotheses have already been tested by others in our group and will be noted when relevant in linked preregistrations. A clear delineation of what hypotheses have been tested and which have yet to be tested will be included when necessary.
Supplementary_Material_Primates_Brain_Sympatry
Creators: name: Robira, Benjamin
name: Perez-Lamarque, Benoit
Publisher: name: Zenodo
Year: 2023

description: This is the supplementary material associated to the publication "Primate sympatry shapes the evolution of their brain architecture" by Benjamin Robira and Benoît Perez-Lamarque.
title: 5.-8. April 2022
Creators: name: Strotmann, Carsten
name: Koetter, Patrick Ben
name: van Rijswijk-Deij, Roland
name: de Brün, Markus
name: Kölligan, Anders
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: IP-Fragmentierung||DNS Cache Poisoning||DNS-Resolver||DNSSEC

description: Caches von DNS-Resolvern können mit fragmentierten IP-Paketen kompromittiert werden. Die BSI-Studie „IP Fragmentation and Measures against DNS Cache Poisoning (Frag-DNS)“ ist der Frage nachgegangen ob und wie häufig IP-Fragmentierung auf „natürliche Weise“ im Internet vorkommt. Sie hat mögliche Gegenmaßnahmen getestet und empfiehlt einige, die mit wenig Veränderung Abhilfe schaffen. Die Studie wird unter https://bsi.bund.de/dok/frag-dns publiziert.
title: 5.-8. April 2022
title: A Framework for More Privacy-Preserving Timestamp Data Types
titleType: Subtitle
Creators: name: Burkert, Christian
name: Balack, Jonathan
name: Federrath, Hannes
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: Privacy by design||data minimisation||timestamps

description: Case studies of application software data models indicate that timestamps are excessively used in connection with user activity. This contradicts the principle of data minimisation which demands a limitation to data necessary for a given purpose. Prior work has also identified common purposes of timestamps that can be realised by more privacy-preserving alternatives like counters and dates with purpose-oriented precision. In this paper, we follow up by demonstrating the real-world applicability of those alternatives. We design and implement three timestamp alternatives for the popular web development framework Django and evaluate their practicality by replacing conventional timestamps in the project management application Taiga.
title: 5.-8. April 2022
title: Debating Ethics with Cybersecurity Students
titleType: Subtitle
Creators: name: Breig, Jan
name: Westhoff, Dirk
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: Cybersecurity||ethical frameworks||offensive security techniques

description: We aim to debate and eventually be able to carefully judge how realistic the following statement of a young computer scientist is: “I would like to become an ethical correctly acting offensive cybersecurity expert”. The objective of this article is not to judge what is good and what is wrong behavior nor to present an overall solution to ethical dilemmas. Instead, the goal is to become aware of the various personal moral dilemmas a security expert may face during his work life. For this, a total of 14 cybersecurity students from HS Offenburg were asked to evaluate several case studies according to different ethical frameworks. The results and particularities are discussed, considering different ethical frameworks. We emphasize, that different ethical frameworks can lead to different preferred actions and that the moral understanding of the frameworks may differ even from student to student.
Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis
Creators: name: Bucher, Elizabeth S.
name: Johnson, Justin A.
name: Fox, Megan E.
name: Wightman, R. Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Central norepinephrine signaling influences a wide range of behavioral and physiological processes, and the ventral bed nucleus of the stria terminalis (vBNST) receives some of the densest norepinephrine innervation in the brain. Previous work describes norepinephrine neurons as projecting primarily unilaterally; however, recent evidence for cross-hemispheric catecholamine signaling challenges this idea. Here, we use fast-scan cyclic voltammetry and retrograde tracing to characterize cross-hemispheric norepinephrine signaling in the vBNST. We delivered stimulations to noradrenergic pathways originating in the A1/A2 and locus coeruleus and found hemispherically equivalent norepinephrine release in the vBNST regardless of stimulated hemisphere. Unilateral retrograde tracing revealed that medullary, but not locus coeruleus norepinephrine neurons send cross-hemispheric projections to the vBNST. Further characterization with pharmacological lesions revealed that stimulations of the locus coeruleus and its axon bundles likely elicit vBNST norepinephrine release through indirect activation. These experiments are the first to demonstrate contralateral norepinephrine release and establish that medullary, but not coerulean neurons are responsible for norepinephrine release in the vBNST.
On the Complexity of Robust PCA and $\ell_1$-norm Low-Rank Matrix Approximation
Creators: name: Gillis, Nicolas
name: Vavasis, Stephen A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: Computational Complexity (cs.CC)
subject: Numerical Analysis (math.NA)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The low-rank matrix approximation problem with respect to the component-wise $\ell_1$-norm ($\ell_1$-LRA), which is closely related to robust principal component analysis (PCA), has become a very popular tool in data mining and machine learning. Robust PCA aims at recovering a low-rank matrix that was perturbed with sparse noise, with applications for example in foreground-background video separation. Although $\ell_1$-LRA is strongly believed to be NP-hard, there is, to the best of our knowledge, no formal proof of this fact. In this paper, we prove that $\ell_1$-LRA is NP-hard, already in the rank-one case, using a reduction from MAX CUT. Our derivations draw interesting connections between $\ell_1$-LRA and several other well-known problems, namely, robust PCA, $\ell_0$-LRA, binary matrix factorization, a particular densest bipartite subgraph problem, the computation of the cut norm of $\{-1,+1\}$ matrices, and the discrete basis problem, which we all prove to be NP-hard.
description: 16 pages, some typos corrected
title: 5.-8. April 2022
Creators: name: Garske, Viktor
name: Noack, Andreas
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: Neural networks||privacy||machine learning||computer vision||password||credentials||pixelized

description: Pixelation is a common technique to redact sensitive information like credentials in images. In this paper, we propose a system that is able to recover information from pixelized text. Our contribution consists of a neural network as well as a generic pipeline that generates a realistic training dataset considering flexible specifications including wordlists, fonts, font sizes and letter spacings. The contributed neural network is a composition of a Convolutional Neural Network (CNN), a Recurrent Neural Network (RNN) using Long short-term memory (LSTM) and a Connectionist Temporal Classification (CTC) layer to decode sequences of characters. With our approach, we achieve a Label Error Rate (LER) under 50% when taking pixelation block sizes of up to 8 × 8 pixels on a 22pt font into account. Thereby, our results indicate that pixelation of sensitive data does not satisfy common privacy standards.
Functional capacity, type of stroke, and psychosocial adaptation are the factors related to the quality of life three months after stroke
Creators: name: Dharma, Kelana
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Nursing
subject: FOS: Health sciences
subject: functional capacity
subject: psycho-social adaptation
subject: quality of life
subject: stroke

description: This is an article of the first Pontianak International Health Conference (PIHC), held on 21-23 November 2017 in Pontianak, Indonesia
Identification of the First Marine-Derived Opioid Receptor “Balanced” Agonist with a Signaling Profile That Resembles the Endorphins
Creators: name: Milan-Lobo, Laura
name: Whistler, Jennifer L.
name: Che, Tao
name: Johnson, Tyler A.
name: Lambu, Eptisam
name: McIntosh, Nicole L.
name: Lorig-Roach, Nicholas
name: Li, Fei
name: Crews, Phillip
name: He, Li
name: Ferwerda, Madeline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Opioid therapeutics are excellent analgesics, whose utility is compromised by dependence. Morphine (1) and its clinically relevant derivatives such as OxyContin (2), Vicodin (3), and Dilaudid (4) are "biased" agonists at the μ opioid receptor (OR), wherein they engage G protein signaling but poorly engage β-arrestin and the endocytic machinery. In contrast, endorphins, the endogenous peptide agonists for ORs, are potent analgesics, show reduced liability for tolerance and dependence, and engage both G protein and β-arrestin pathways as "balanced" agonists. We set out to determine if marine-derived alkaloids could serve as novel OR agonist chemotypes with a signaling profile distinct from morphine and more similar to the endorphins. Screening of 96 sponge-derived extracts followed by LC-MS-based purification to pinpoint the active compounds and subsequent evaluation of a mini library of related alkaloids identified two structural classes that modulate the ORs. These included the following: aaptamine (10), 9-demethyl aaptamine (11), demethyl (oxy)-aaptamine (12) with activity at the δ-OR (EC50: 5.1, 4.1, 2.3 μM, respectively) and fascaplysin (17), and 10-bromo fascaplysin (18) with activity at the μ-OR (EC50: 6.3, 4.2 μM respectively). An in vivo evaluation of 10 using δ-KO mice indicated its previously reported antidepressant-like effects are dependent on the δ-OR. Importantly, 17 functioned as a balanced agonist promoting both G protein signaling and β-arrestin recruitment along with receptor endocytosis similar to the endorphins. Collectively these results demonstrate the burgeoning potential for marine natural products to serve as novel lead compounds for therapeutic targets in neuroscience research.
title: 5.-8. April 2022
title: How to find differences between programs that mostly behave identically?
titleType: Subtitle
Creators: name: Möller, Jonas
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: Differential Testing||Fuzzing

description: Differences between programs based on the same specification might lead to vulnerabilities that can not be detected by conventional testing. Differential testing is able to find these discrepancies by executing multiple programs on the same input and comparing their output. In this work, we discuss the fundamentals of differential testing and outline a general scheme for differential testing methods which is used to categorize and analyze current research approaches. Based on this, we formulate our own research questions which focus on how machine learning can aid differential testing
Population processes sampled at random times
Creators: name: Beghin, L.
name: Orsingher, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G55, 60J80

description: In this paper we study the iterated birth process of which we examine the first-passage time distributions and the hitting probabilities. Furthermore, linear birth processes, linear and sublinear death processes at Poisson times are investigated. In particular, we study the hitting times in all cases and examine their long-range behavior. The time-changed population models considered here display upward (Birth process) and downward jumps (death processes) of arbitrary size and, for this reason, can be adopted as adequate models in ecology, epidemics and finance situations, under stress conditions.
description: 19 pages, 3 figures
The Effectiveness of Victim Empathy Treatment For Child Sex Offenders: A Mini Systematic Review
Creators: name: Jeanneault, Emily
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Applied Behavior Analysis
subject: Criminal Law
subject: Counseling
subject: Social Work
subject: FOS: Sociology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Law
subject: FOS: Law

description: A mini systematic review of studies that have examined the impact of sex offender treatment programs that have a particular focus on victim empathy training will be conducted. The aim is to obtain a better understanding of the treatments effectiveness and its relation to recidivism within this population. Many treatment programs incorporate empathy/victim empathy training with the hope that it will leave to reduced recidivism amount convicted sex offenders (Fernandez & Marshall, 2003).
title: 5.-8. April 2022
title: How to Pass the Reverse Turing Test By Utilizing a VMI-Based Human Interaction Simulator
titleType: Subtitle
Creators: name: Gruber, Jan
name: Freiling, Felix C.
Publisher: name: Gesellschaft für Informatik, Bonn
Year: 2022
Subjects: subject: Malware Analysis||Sandboxing||Virtual Machine Introspection||Reverse Turing Test

description: Sandboxes are an indispensable tool in dynamic malware analysis today. However, modern malware often employs sandbox-detection methods to exhibit non-malicious behavior within sandboxes and therefore evade automatic analysis. One category of sandbox-detection techniques are reverse Turing tests (RTTs) to determine the presence of a human operator. In order to pass these RTTs, we propose a novel approach which builds upon virtual machine introspection (VMI) to automatically reconstruct the graphical user interface, determine clickable buttons and inject human interface device events via direct control of virtualized human interface devices in a stealthy way. We extend the VMI-based open-source sandbox DRAKVUF with our approach and show that it successfully passes RTTs commonly employed by malware in the wild to detect sandboxes
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2
Creators: name: James, Lindsey I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The function of EED within Polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. Allosteric activation of PRC2 by binding of methylated proteins to EED’s aromatic cage is essential for full catalytic activity, but details of this regulation are not fully understood. EED’s recognition of the product of PRC2 activity, histone H3 lysine 27 trimethylation (H3K27me3), stimulates PRC2 methyltransferase activity at adjacent nucleosomes leading to H3K27me3 propagation and, ultimately, gene repression. By coupling combinatorial chemistry and structure-based design, we optimized a low affinity methylated Jarid2 peptide to a smaller, more potent peptidomimetic ligand (Kd = 1.14 ± 0.14 μM) of the aromatic cage of EED. Our strategy illustrates the effectiveness of applying combinatorial chemistry to achieve both ligand potency and property optimization. Furthermore, the resulting ligands, UNC5114 and UNC5115, demonstrate that targeted disruption of EED’s reader function can lead to allosteric inhibition of PRC2 catalytic activity.
Thinning Algorithm Using Hypergraph Based Morphological Operators
Creators: name: Prakash, R. P.
name: Prakash, Keerthana S.
name: Binu, V. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: The object recognition is a complex problem in the image processing. Mathematical morphology is Shape oriented operations, that simplify image data, preserving their essential shape characteristics and eliminating irrelevancies. This paper briefly describes morphological operators using hypergraph and its applications for thinning algorithms. The morphological operators using hypergraph method is used to preventing errors and irregularities in skeleton, and is an important step recognizing line objects. The morphological operators using hypergraph such as dilation, erosion, opening, closing is a novel approach in image processing and it act as a filter remove the noise and errors in the images.
description: Advance Computing Conference (IACC), 2015 IEEE International,Banglore India
Roll Pass Design of UIC 60 Rail Using Finite Element Method
Creators: name: Mesfin Akmel
Publisher: name: Zenodo
Year: 2015

description: In metal forming, a simple geometry, bloom or billet, is plastically deformed between tools to obtain the desired geometry. Hot rolling is one of the main metal forming processes. The rail sections are generally made of carbon steels by hot rolling process. The rolling of rail section is carried out in number of passes. For converting initial steel bloom into final rail section, the bloom is passed between numbers of rollers. Each roller has different grooves on it. The shape of groove decides the rolled section at each pass. So, to get desired section of each pass, I designed the sections which, in turn, reduce its cross-sectional area. The final finishing pass gives the standard UIC 60 rail section used in railways. The aim of this paper is to present the developed procedure for the simulation of the hot rolling process of UIC 60 rail. The full rolling process of this rail consists of ten shape passes in different grooves, only one pass in each groove (five in roughing stand and five in the finishing stand). The simulation was carried out by using a finite element analysis called DEFORM 3D.
title: Catching the released: conservation and aquaculture's shared colonial lineages in Newfoundland and Labrador
Creators: name: Baird, Christopher
Publisher: name: Memorial University of Newfoundland
Year: 2022

description: Aquaculture is a booming industry in the province of Newfoundland and Labrador. Industrial salmon farming has potential to provide employment and generate economic activity in a region previously devastated by the collapse of northern cod stocks. However, the aquaculture industry, which was once heavily supported by conservation groups and thought to alleviate pressure on wild salmon stocks, is now a suspected contributor to the decline of wild salmon. After decades of operation, it has become clear that the practice of commercial salmon farming has many shortcomings. Although salmon anglers and aquaculturists appear to be in diametrically opposed conflict on the question of further aquaculture development in the province, these groups share a common colonial lineage in the province of Newfoundland and Labrador. Left out of this discussion are the voices of the Mi’kmaw salmon anglers of Miawpukek First Nation who have been profoundly impacted by the decline of wild Atlantic salmon, a fish of historical, economic and cultural importance. The differing perspectives among the loudest settler voices represented by the salmonid industry and salmonid conservation groups, and the mostly silenced voices of the Mi’kmaw, stem from epistemological and ontological differences in what fish are understood to be and have been heavily influenced by settler colonial relations. In this thesis, I focus on understanding the apparent conflict between the salmonid aquaculture industry and salmonid conservation groups in Newfoundland and Labrador. Through an analysis of their shared settler colonial lineage, I find that these groups come together in their promotion of the science and technology of closed containment aquaculture and in their singular focus on understanding fish as resources and capital. While disputes between salmonid aquaculture developers and conservationists on the island of Newfoundland have become the dominant voices, Mi’kmaw salmon anglers belonging to Miawpukek First Nation know and relate to salmonids differently outside the colonial lineage of settler anglers and aquaculturalists.
title: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 48 (1970)
title: Band 48 (1970)
titleType: AlternativeTitle
Creators: name: Germania : Anzeiger Der Römisch-Germanischen Kommission Des Deutschen Archäologischen Instituts
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Verfasserverzeichnis der Bibliothekszugänge in Germania 48, 1970...415-448 Walter Torbrügge und Hans P. Uenze, Bilder zur Vorgeschichte Bayerns...231-232 Klaus Ludwig Voss, Die Vor- und Frühgeschichte des Kreises Ahaus...229-231 Gerhard Bersu und David M. Wilson, Three Viking Graves in the Isle of Man...219-224 Willy Groenman-van Waateringe, Romeins lederwerk uit Valkenburg Z.H....205-206 Christoph B. Rüger, Germania Inferior...201-205 W. A. van Es, Wijster, a Native Village beyond the Imperial Frontier 150—425 A.D....192-198 Erzsébet Patek, Die Urnenfelderkultur in Transdanubien...165-170 Wolfgang Kimmig, Der Kirchberg bei Reusten...152-156 Neolithic Studies in Atlantic Europe...143-152 Hermann Müller-Karpe, Handbuch der Vorgeschichte...137-143 Frühe Menschheit und Umwelt, Teil II...135-137 Ovales Bronzetablett mit Besitzerinschrift von Haßleben, Kr. Erfurt. Eine Neubetrachtung...130-133 Möglichkeiten der ¹⁴C-Datierung...98-109 Die Stellung der männlichen Statuette aus dem Hohlenstein-Stadel in der jungpaläolithischen Kunst...1-12 Inhalt Widmung Titelei
title: Fatal necrotising emphysematous pancreatitis
Creators: name: Arévalo Martín, Cristina
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Abdominal imaging
subject: Abdomen
subject: Emergency
subject: Pancreas
subject: CT
subject: Complications
subject: Infection
subject: Clinical Cases

description: Clinical History: A 63-year-old man with a medical history of hypertension, dyslipidemia and no prior surgeries, was admitted to the emergency department with severe epigastric pain radiating to the back and vomiting that started 6 hours before admission. Physical examination showed generalised abdominal tenderness, hypotension, tachycardia and tachypnea. Laboratory analysis revealed leucocytosis, elevated amylase, and metabolic acidosis with hyperlactatemia.

description: 63 years, male
Identification of Small Molecule Inhibitors That Block the Toxoplasma gondii Rhoptry Kinase ROP18
Creators: name: Tang, Keliang
name: Stashko, Michael
name: Hui, Raymond
name: Janzen, William
name: Schapira, Matthieu
name: Sibley, L. David
name: Jones, Nathaniel G.
name: Simpson, Catherine
name: Kireev, Dmitri
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The protozoan parasite Toxoplasma gondii secretes a family of serine-threonine protein kinases into its host cell in order to disrupt signaling and alter immune responses. One prominent secretory effector is the rhoptry protein 18 (ROP18), a serine-threonine kinase that phosphorylates immunity related GTPases (IRGs) and hence blocks interferon gamma-mediated responses in rodent cells. Previous genetic studies show that ROP18 is a major virulence component of T. gondii strains from North and South America. Here, we implemented a high throughput screen to identify small molecule inhibitors of ROP18 in vitro and subsequently validated their specificity within infected cells. Although ROP18 was not susceptible to many kinase-directed inhibitors that affect mammalian kinases, the screen identified several sub micromolar inhibitors that belong to three chemical scaffolds: oxindoles, 6-azaquinazolines, and pyrazolopyridines. Treatment of interferon gamma-activated cells with one of these inhibitors enhanced immunity related GTPase recruitment to wild type parasites, recapitulating the defect of Δ rop18 mutant parasites, consistent with targeting ROP18 within infected cells. These compounds provide useful starting points for chemical biology experiments or as leads for therapeutic interventions designed to reduce parasite virulence.
Temporal Dynamics of COVID Symptoms
Creators: name: Frumkin, Madelyn
name: Rodebaugh, Thomas
name: Lenze, Eric
name: Yang, Lei
name: Miller, Philip
name: Stevens, Angela
name: Schweiger, Julia
name: Mattar, Caline
name: Zorumski, Charles
name: Reiersen, Angela
name: Nicol, Ginger
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: COVID-19

description: This is an open-ended pre-registration containing plans for data analysis.
ENTRE O REAL E O VIRTUAL
Creators: name: Pavao Santana, Jose Claudio
Publisher: name: Zenodo
Year: 2025

description: Ano 11 – n. 59/2023 – https://doi.org/10.5281/zenodo.8364984

O Supremo Tribunal Federal anunciou que a continuação dos

julgamentos dos processos que tratam do que alguns

insistem em chamar de “atos antidemocráticos”, prosseguirá

pelo sistema de “plenário virtual”. O sistema é

regimentalmente previsto, colhendo-se do sítio do tribunal a

seguinte informação:
Amendment - Ethical advice-taking in dyadic die-rolling paradigm from AI vs Human
Creators: name: Hagens, Marloes
name: Köbis, Nils
name: Leib, Margarita
name: Rilke, Rainer
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Behavioral Economics
subject: Economics
subject: Social and Behavioral Sciences

description: This project contains an experimental study of ethical advice-giving and -taking. Ethical in this context means (dis)honest behavior, and the advice-giving thus means advocating (dis)honest behavior. The dyadic die-roll set-up was altered to add an adviser player. In an behavioral and experimental economic context, the tendency towards giving (dis)honest advice is studied.
Solid Holography and Massive Gravity
Creators: name: Alberte, Lasma
name: Baggioli, Matteo
name: Khmelnitsky, Andrei
name: Pujolas, Oriol
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Momentum dissipation is an important ingredient in condensed matter physics that requires a translation breaking sector. In the bottom-up gauge/gravity duality, this implies that the gravity dual is massive. We start here a systematic analysis of holographic massive gravity (HMG) theories, which admit field theory dual interpretations and which, therefore, might store interesting condensed matter applications. We show that there are many phases of HMG that are fully consistent effective field theories and which have been left overlooked in the literature. The most important distinction between the different HMG phases is that they can be clearly separated into solids and fluids. This can be done both at the level of the unbroken spacetime symmetries as well as concerning the elastic properties of the dual materials. We extract the modulus of rigidity of the solid HMG black brane solutions and show how it relates to the graviton mass term. We also consider the implications of the different HMGs on the electric response. We show that the types of response that can be consistently described within this framework is much wider than what is captured by the narrow class of models mostly considered so far.
description: 43 pages, 4 figures
Large Networks of Diameter Two Based on Cayley Graphs
Creators: name: Abas, Marcel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: In this contribution we present a construction of large networks of diameter two and of order $\frac{1}{2}d^2$ for every degree $d\geq 8$, based on Cayley graphs with surprisingly simple underlying groups. For several small degrees we construct Cayley graphs of diameter two and of order greater than $\frac23$ of Moore bound and we show that Cayley graphs of degrees $d\in\{16,17,18,23,24,31,\dots,35\}$ constructed in this paper are the largest currently known vertex-transitive graphs of diameter two.
description: 9 pages, Published in Cybernetics and Mathematics Applications in Intelligent Systems
Clinical Implications of Concussions Diagnosed with Head Impact Sensors: A Systematic Review and Meta-Analysis
Creators: name: Jacquier, Christina
name: Salamh, Paul
name: Luck, Jason
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Health Information Technology
subject: Sports Sciences
subject: Medicine and Health Sciences
subject: Rehabilitation and Therapy
subject: Engineering
subject: Biomedical Engineering and Bioengineering
subject: Concussion
subject: Head Impact Sensors

description: We aim to complete a systematic review and meta-analysis investigating the use of head impact sensors used for monitoring and diagnosing concussion and sub-concussive impacts in athletes. Our review research questions are as follows: 1. In athletes wearing head impact sensors, what is the criteria currently being used to diagnose a concussion? 2. What is the clinical picture of individuals diagnosed with concussive events by head impact sensors?
A tetrahedral space-filling curve for non-conforming adaptive meshes
Creators: name: Burstedde, Carsten
name: Holke, Johannes
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Mathematical Software (cs.MS)
subject: FOS: Computer and information sciences
subject: 65M50, 68W10, 65Y05, 65D18

description: We introduce a space-filling curve for triangular and tetrahedral red-refinement that can be computed using bitwise interleaving operations similar to the well-known Z-order or Morton curve for cubical meshes. To store sufficient information for random access, we define a low-memory encoding using 10 bytes per triangle and 14 bytes per tetrahedron. We present algorithms that compute the parent, children, and face-neighbors of a mesh element in constant time, as well as the next and previous element in the space-filling curve and whether a given element is on the boundary of the root simplex or not. Our presentation concludes with a scalability demonstration that creates and adapts selected meshes on a large distributed-memory system.
description: 33 pages, 12 figures, 8 tables
Comparison between different exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network metanalysis of randomized controlled trials.
Creators: name: Monami, Matteo
name: Mannucci, Edoardo
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: We conducted a network meta-analysis to assess the comparative impact of different exercise training modalities on glycemic control, blood pressure, and weight loss in patients with type 2 diabetes.