cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessing breast cancer-related breast lymphoedema using indocyanine green lymphography
Creators: name: Heydon-White, Asha Kaiyu
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Breast lymphoedema is a potential complication for women undergoing breast-conserving therapy for breast cancer. It is characterised by chronic swelling and tissue changes in the breast, which can cause discomfort, increased susceptibility to cellulitis, and negatively impact the sufferer's quality of life. Despite this breast lymphoedema remains under-recognised and under-reported. This can be attributed, at least in part, to the lack of a standardised assessment method. This thesis explores breast lymphoedema, specifically the current methods available to assess this condition and proposes a new method of assessment, indocyanine green (ICG) lymphography. ICG lymphography is a validated assessment method for breast cancer-related arm lymphoedema. However, its use in breast lymphoedema has not been examined. Therefore, a pilot study recruiting two groups of participants (10 healthy controls, and 10 breast lymphoedema participants) was undertaken to determine if ICG lymphography could be utilised as an assessment method for this condition. Additionally, ICG lymphography was used to map the lymphatic drainage pathways of the breast in both participant groups to determine if these drainage pathways are altered following breast conserving therapy. In this pilot study, ICG lymphography detected morphological changes to the lymphatic vasculature diagnostic of lymphoedema (dermal backflow and collateral lymphatic drainage) in all breast lymphoedema participants and none of the healthy control participants. Furthermore, lymphatic drainage pathways of the breast differed between the two groups. In the healthy control group lymph drained exclusively to the ipsilateral axilla region. In the breast lymphoedema group lymph drained to the: i) parasternal (6/10); ii) ipsilateral axilla (4/10); iii) contralateral axilla (4/10); iv) intercostal (3/10) and v) clavicular (2/10) regions. These findings support the use of ICG lymphography in the assessment of breast lymphoedema. Additionally, understanding the lymphatic drainage pathways of the breast will have clinical implications for breast lymphoedema management. This pilot study serves to direct future research that examines the role of ICG lymphography not only in the assessment of breast lymphoedema but its diagnosis, management, and monitoring.
Additional file 1: Table S1. of Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd
Creators: name: Silaghi, Cornelia
name: Nieder, Marion
name: Sauter-Louis, Carola
name: Knubben-Schweizer, Gabriela
name: Pfister, Kurt
name: Pfeffer, Martin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Primers used for the PCR amplifications and sequence analysis of Anaplasma phagocytophilum in this study. (DOC 33Â kb)
Concentrated solar thermal linear Fresnel lens
Creators: name: Cleal, Joel
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Australia's ageing network of coal fired power stations, combined with the world's move away from fossil fuels, has created a unique opportunity for the generation of renewable energy in Australia. This paper will focus on the emerging technology of concentrated solar thermal (CST), and, more specifically, investigate the use of a linear Fresnel lens as an alternative method of CST generation. CST systems work by concentrating solar energy onto a receiver to generate heat, which is then transferred to water either directly or through a heat exchanger for use in a conventional steam turbine. Currently there are no commercial CST plants operating in Australia, primarily due to high costs in comparison with existing renewables, and a lack of government support. to investigate the suitability of a linear Fresnel lens system, a small prototype was was developed and a number of experimental analyses conducted. The results indicated that a CST technique based on lens magnification can produce high working temperatures an efficiencies, along with several different advantages over existing CST methods. These include reduced environmental impacts, decreased maintenance requirements, and lower operating costs. Additionally, the experimental results indicated that a linear Fresnel CST system could be implemented into industries that require the use of low process heat. These include the food, textile and chemical industries, with process heat in the low to medium temperature ranges of between 80°C-250°C accounting for over 30% of total industrial energy consumptioon.
Impact of switching prophylaxis treatment from factor VIII to emicizumab in hemophilia A patients without inhibitors
Creators: name: Escobar, Miguel
name: Agrawal, Neha
name: Chatterjee, Sagnik
name: Bhattacharya, Swastik
name: Caicedo, Jorge
name: Bullano, Michael
name: Schultz, Bob G.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Factor VIII (FVIII) replacement and emicizumab are effective at preventing bleeds in patients with hemophilia A (HA). Though benefits of emicizumab among inhibitor patients with HA (PwHA) are well established, more real-world evidence among non-inhibitor patients is needed. Using a United States healthcare claims database, we compared billed annualized bleed rates (ABRb) and the total cost of care (TCC) before and after switching from FVIII prophylaxis to emicizumab among non-inhibitor male PwHA. Bayesian inferences were used to assess the difference in ABRb and TCC per patient per year (PPPY) pre- versus post-prophylaxis switch. We included 101 non-inhibitor male PwHA aged between 3 and 63 years old who switched from FVIII prophylaxis to emicizumab prophylaxis in 2018 or 2019. The ABRb increased from 0.52 to 0.62 (p = 0.83) after switch. The posterior probability of the mean ABRb increasing after the switch was 75.54%. The TCC PPPY increased from $517,143 to $627,005 (p < 0.0001) after switch and the posterior probability of mean costs increasing after the switch was 99.80%. Personalization of care through the identification of the most appropriate therapy for each patient can optimize clinical and economic outcomes. Future real-world evidence research could help establish the value of prophylactic options in targeted populations such as the non-inhibitor male PwHA.
title: ADCO, Ordre cistercien : comptes (1403-1423) (11 H 1161), f. 00097
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161), f. 00097, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
Additional file 2 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Creators: name: Guo, Na
name: Zhu, Ying
name: Tian, Dandan
name: Zhao, Yating
name: Zhang, Chenguang
name: Mu, Changqing
name: Han, Chen
name: Zhu, Ruixia
name: Liu, Xu
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 2: Table S2. Characteristics of included meta-analyses evaluating associations between food groups, foods as well as beverages and stroke risk.
Choosing an offshore international program: a study of transnational higher education in Hong Kong
Creators: name: Ng, Chak Wah
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The demand for international higher education is increasing at an unprecedented rate, and transnational education makes up a significant proportion of the international higher education sector. With the expansion of the transnational market, a deeper understanding of students’ behaviour in choosing a transnational institution, and in choosing a program, is important to ensure that student needs are met and to improve the capability of transnational education providers to offer relevant and valued education. The main purpose of this research was to study the university choice process and to identify the factors that influence students in the process of choosing an offshore international program. The context was the transnational higher education sector in Hong Kong. This research adopted as its theoretical framework the concepts of Hossler and Gallagher’s school choice model and the push-pull model of international education. Using a mixed-methods approach, survey questionnaires were collected from 496 offshore international students enrolled in 12 programs from five universities, andqualitative data were collected from semi-structured interviews with 20 students. Findings showed that the university choice of offshore international students is a multi-dimensional decision process which combines a variety of factors at different stages. Unlike most previous studies, the country effect was found to be less significant for offshore than for onshore international students. The local partner institution played an important role in the transnational university choice process. The Modified Transnational University Choice model developed here reflects the interaction of the program effect, the transnational push and pull effect, and the influences of theuniversity and local partner institutions. The discussion, recommendations and conclusions from this research are relevant for administrators and policy makers of transnational education providers, and contribute to the management practice and the current body of knowledge on international education.
Additional file 9: Figure S9. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Creators: name: Yun, Seung
name: Donghoon Kim
name: Sangjune Kim
name: SangMin Kim
name: Senthilkumar Karuppagounder
name: Seung-Hwan Kwon
name: Saebom Lee
name: Tae-In Kam
name: Suhyun Lee
name: Sangwoo Ham
name: Park, Jae
name: Valina Dawson
name: Dawson, Ted
name: Yunjong Lee
name: Ko, Han
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology

description: L444P GBA heterozygous mutation leads to autophagy abnormality. a, b Effect of rapamycin on GBA +/L444P expression. Primary cortical neurons were cultured from WT and GBA +/L444P mice. After 10 DIV, primary neurons were treated with 20 nM of rapamycin (mTOR inhibitor for inducing autophagy) for 24 h. a Representative Immunoblots of GBA. b GBA expression levels were normalized against β-actin and the error bars represent the mean ± S.E.M (n = four per group). c Immunoblots of Autophagy marker proteins SQSTM1/p62, and LC3A/B-I/II. VMB lysates were immunoblotted with anti-SQSTM1/p62, and anti-LC3A/B-I/II antibodies. d SQSTM1/p62, and e LC3A/B-II expression levels were normalized against β-actin. Error bars represent the mean ± S.E.M (n = four mice per group). Two-way ANOVA was used for statistical analysis followed by post-hoc Bonferroni test for multiple group comparison. *P
Searching for Moving Objects in HSC-SSP: Pipeline and Preliminary Results
Creators: name: Chen, Ying-Tung
name: Lin, Hsing-Wen
name: Alexandersen, Mike
name: Lehner, Matthew J.
name: Wang, Shiang-Yu
name: Wang, Jen-Hung
name: Yoshida, Fumi
name: Komiyama, Yutaka
name: Miyazaki, Satoshi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is currently the deepest wide- field survey in progress. The 8.2 m aperture of Subaru telescope is very powerful in detect- ing faint/small moving objects, including near-Earth objects, asteroids, centaurs and Tran- Neptunian objects (TNOs). However, the cadence and dithering pattern of the HSC-SSP are not designed for detecting moving objects, making it difficult to do so systematically. In this paper, we introduce a new pipeline for detecting moving objects (specifically TNOs) in a non-dedicated survey. The HSC-SSP catalogs are re-arranged into the HEALPix architecture. Then, the stationary detections and false positive are removed with a machine learning al- gorithm to produce a list of moving object candidates. An orbit linking algorithm and visual inspections are executed to generate the final list of detected TNOs. The preliminary results of a search for TNOs using this new pipeline on data from the first HSC-SSP data release (Mar 2014 to Nov 2015) are also presented.
description: 32 pages, 10 figures, 2 tables, submitted to HSC special issue in PASJ
Effects of stratification on overshooting and waves atop the convective core of $5M_{\odot}$ main-sequence stars
Creators: name: Morison, Adrien
name: Saux, Arthur Le
name: Baraffe, Isabelle
name: Morton, Jack
name: Guillet, Thomas
name: Vlaykov, Dimitar
name: Goffrey, Tom
name: Pratt, Jane
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: As a massive star evolves along the main sequence, its core contracts, leaving behind a stable stratification in helium. We simulate 2D convection in the core at three different stages of evolution of a $5M_{\odot}$ star, with three different stratifications in helium atop the core. We study the propagation of internal gravity waves in the stably-stratified envelope, along with the overshooting length of convective plumes above the convective boundary. We find that the stratification in helium in evolved stars hinders radial motions and effectively shields the radiative envelope against plume penetration. This prevents convective overshooting from being an efficient mixing process in the radiative envelope. In addition, internal gravity waves are less excited in evolved models compared to the zero-age-main-sequence model, and are also more damped in the stratified region above the core. As a result, the wave power is several orders of magnitude lower in mid- and terminal-main-sequence models compared to zero-age-main-sequence stars.
Additional file 8: Figure S8. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Creators: name: Yun, Seung
name: Donghoon Kim
name: Sangjune Kim
name: SangMin Kim
name: Senthilkumar Karuppagounder
name: Seung-Hwan Kwon
name: Saebom Lee
name: Tae-In Kam
name: Suhyun Lee
name: Sangwoo Ham
name: Park, Jae
name: Valina Dawson
name: Dawson, Ted
name: Yunjong Lee
name: Ko, Han
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Cancer

description: GBA overexpression inhibits MPTP-reduced mitochondrial protein level in GBA +/L444P mice. a Immunoblots of SDHA, PDH, VDAC, TH, GBA, and α-synuclein from AAV5-Con injected WT, AAV5-hGBA injected WT, AAV5-Con injected heterozygous, and AAV5-hGBA injected heterozygous mice treated with saline or MPTP. VMB lysates were immunoblotted with anti-SDHA, anti-PDH, anti-VDAC, anti-TH, and anti-GBA antibodies. b SDHA, c PDH, d VDAC, e TH, f GBA, and g α-synuclein expression levels were normalized against β-actin. Error bars represent the mean ± S.E.M. (n = three mice per group). Two-way ANOVA was used for statistical analysis followed by post-hoc Bonferroni test for multiple group comparison. *P
Multi-Color Simultaneous Photometry of the T-Tauri Star Having A Planetary Candidate CVSO 30
Creators: name: Onitsuka, Masahiro
name: Fukui, Akihiko
name: Narita, Norio
name: Hirano, Teruyuki
name: Kusakabe, Nobuhiko
name: Ryu, Tsuguru
name: Tamura, Motohide
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present three-band simultaneous observations of a weak-line T-Tauri star CVSO~30 (PTFO~8-8695), which is one of the youngest objects having a candidate transiting planet. The data were obtained with the Multicolor Simultaneous Camera for studying Atmospheres of Transiting exoplanets (MuSCAT) on the 188 cm telescope at Okayama Astrophysical Observatory in Japan. We observed the fading event in the $g^{\prime}_2$-, $r^{\prime}_2$-, and $z_{\rm s,2}$-bands simultaneously. As a result, we find a significant wavelength dependence of fading depths of about 3.1\%, 1.7\%, 1.0\% for the $g^{\prime}_2$-, $r^{\prime}_2$-, and $z_{\rm s,2}$-bands, respectively. A cloudless H/He dominant atmosphere of a hot Jupiter cannot explain this large wavelength dependence. Additionally, we rule out a scenario by the occultation of the gravity-darkened host star. Thus our result is in favor of the fading origin as circumstellar dust clump or occultation of an accretion hotspot.
description: 6 pages, 3 figures, Accepted for PASJ Letters
Ten-year cost-consequence analysis of weight loss on obesity-related outcomes in privately insured adults with obesity in Saudi Arabia
Creators: name: Al-Omar, Hussain A
name: Aljehani, Nasser
name: Alshehri, Ali
name: Al-Khenizan, Abdullah
name: Al-Shammari, Faisal
name: Abanumay, Abdulmohsen
name: Schnecke, Volker
name: Carapinha, João L.
name: Alqhatani, Saleh A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: This study aimed to estimate the 10-year cost-consequence of weight loss on obesity-related outcomes in a sample of privately insured adults with obesity in Saudi Arabia (KSA). We analyzed data of adults with obesity (BMI ≥ 30 kg/m2) available in Nphies, the private health insurance platform of the Council of Health Insurance, KSA. A micro-costing analysis was used to obtain domestic cost estimates for obesity-related outcomes. Cox proportional hazard models were used to estimate the benefit of weight loss by preventing incident cases of 10 obesity-related outcomes. In the study cohort (n = 314,079), the 30-34.9 BMI category contributed two-thirds of the cohort, and no gender differences were found in the age distribution of BMI categories. The elderly population had a higher prevalence of obesity-related outcomes, such as hypertension, osteoarthritis, and type 2 diabetes mellitus (T2DM). The baseline cost (2023) for treating these outcomes was USD 1.245 billion, which could double in 10 years. A 15% weight loss could save USD 1.295 billion over 10 years, with most savings due to T2DM (USD 430 million), given its higher prevalence (27.5%). The model was most sensitive to cost variability in T2DM, dyslipidemia, and hypertension. The results should be interpreted within the bounds of the study cohort, and Nphies is in its early stages of implementation. The cost estimates may differ if repeated among adults with obesity only, potentially leading to increased cost savings with weight loss. Moderate weight loss of 5-15% over 10 years is associated with substantial cost savings in Saudi Arabia. For a 15% weight loss, 18.8% of incidence cases of obesity-related outcomes may be prevented, and slowed increases in T2DM, dyslipidemia, and hypertension may lead to considerable cost savings. The findings would help policymakers to implement weight loss programs in KSA.
Real estate cycles and bank systemic risks
Creators: name: Ge, Georgina
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis presents an empirical study of the linkages between boom-bust cycles in the real estate market and systemic banking crises. The work contributes to the literature by estimating the conditional probablity of systemic banking crises as a function of time varying market and macroeconomic conditions, as well as characteristic information on real estate markets. The model is expected to offer regulators a quantitative basis for assessing the vulnerability of the financial system to real estate cycles. The findings suggest that a disconnection between credit aggregation to economic output, as well as that between property values and income levels tend to precede banking crises. In addition, growth rates of housing prices in the short-term are found to have a strong predictive power in providing early warning signals for banking crises.
title: ADCO, Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Cart. 198-01 (11 H 1055), 185 folios, f. 0218
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0218, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0218, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Application of semifinite index theory to weak topological phases
Creators: name: Bourne, Chris
name: Schulz-Baldes, Hermann
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Physics (math-ph)
subject: K-Theory and Homology (math.KT)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Recent work by Prodan and the second author showed that weak invariants of topological insulators can be described using Kasparov's $KK$-theory. In this note, a complementary description using semifinite index theory is given. This provides an alternative proof of the index formulae for weak complex topological phases using the semifinite local index formula. Real invariants and the bulk-boundary correspondence are also briefly considered.
description: To appear in the conference proceedings from the MATRIX-program 'Refining C*-algebraic invariants for dynamics using KK-theory' in Creswick, Australia (2016)
Additional file 3 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Creators: name: Guo, Na
name: Zhu, Ying
name: Tian, Dandan
name: Zhao, Yating
name: Zhang, Chenguang
name: Mu, Changqing
name: Han, Chen
name: Zhu, Ruixia
name: Liu, Xu
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 3: Table S3. Characteristics of included meta-analyses evaluating associations between food nutrients and stroke risk.
The distribution of star formation in the SAMI Galaxy Survey: the implications for quenching mechanisms and galaxy evolution
Creators: name: Goldstein, Gregory
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The distribution of the star formation across galaxy disks is examined with integral field spectroscopy to determine if the distribution varies according to the so-called 'main sequence' locus of galaxies on the plane of integrated star-formation rate and galaxy mass. Integral field spectroscopy allows the construction of radial profiles of star formation in the disks of star forming galaxies. The profiles are here used in the testing of various mechanisms that have been proposed for galaxy quenching and evolution. A goal is to determine whether processes local to each galaxy (such as a central process) or global environmental factors such as strangulation are the prime drivers of quenching. A sample of star forming galaxies from the SAMI Galaxy Survey is used, noting that only galaxies with a majority of spaxels in the central area that are star forming are suitable for construction of a radial profile. Galaxies have been classified as main sequence, above-, and below main sequence based on their location in relation to the star formation main sequence ridgeline. The radial profiles of star formation indicate that central suppression of star formation occurs in 16-20 percent of galaxies on, above or below the main sequence. The radial profiles are generally consistent with coherent star formation, whereby whatever the quenching process is that drives reduced SFR, it acts in such a way that SF remains largely coherent across the galaxy body. Coherent star formation favors several proposed quenching mechanisms including strangulation or cosmic web detachment. Central suppression is not a signature of a quenching process, but is consistent with a central process such as the compaction scenario, and cyclic central star formation. This study has been unable to distinguish between quenching from the inside out such as the 'compaction' scenario, and strangulation as a primary quenching mechanism. A weak positive correlation between bulge size and central SF radial profile slope has been detected, however the results do not support a major role of bulges in the initiation of central suppression of star formation.
MOESM1 of The PHARMS (Patient Held Active Record of Medication Status) feasibility study: a research proposal
Creators: name: Walsh, Elaine
name: Sahm, Laura
name: Kearney, Patricia
name: Smithson, Henry
name: Kerins, David
name: Chrys Ngwa
name: Fitzgerald, Ciara
name: Carthy, Stephen Mc
name: Connolly, Eimear
name: Dalton, Kieran
name: Derina Byrne
name: Carey, Megan
name: Bradley, Colin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Patient held medication record. Additional detail on mechanism of patient held medication record.
title: Parental Leave Reform and Long-run Earnings of Mothers
Creators: name: Frodermann, Corinna
name: Wrohlich, Katharina
name: Zucco, Aline
Publisher: name: Universität Potsdam
Year: 2020

description: Paid parental leave schemes have been shown to increase women’s employment rates but de-crease their wages in case of extended leave durations. In view of these potential trade-offs, many countries are discussing the optimal design of parental leave policies. We analyze the impact of a major parental leave reform on mothers’ long-term earnings. The 2007 German parental leave re-form replaced a means-tested benefit with a more generous earnings-related benefit that is grant-ed for a shorter period of time. Additionally, a “daddy quota” of two months was introduced. To identify the causal effect of this policy on long-run earnings of mothers, we use a difference-in-difference approach that compares labor market outcomes of mothers who gave birth just before and right after the reform and nets out seasonal effects by including the year before. Using admin-istrative social security data, we confirm previous findings and show that the average duration of employment interruptions increased for high-income mothers. Nevertheless, we find a positive long-run effect on earnings for mothers in this group. This effect cannot be explained by changes in working hours, observed characteristics, changes in employer stability or fertility patterns. De-scriptive evidence suggests that the stronger involvement of fathers, incentivized by the “daddy months”, could have facilitated mothers’ re-entry into the labor market and thereby increased earnings. For mothers with low prior-to-birth earnings, however, we do not find any beneficial labor market effects of this parental leave reform.
description: CEPA Discussion Papers, 16
2023 Oregon Health Evidence Review Commission (HERC) Rapid Review Receipt of Gender-affirming Medical Interventions
Creators: name: Terdal, Paul
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 420306
subject: Health care administration

description: This is an incomplete draft report by the OHSU Center for Evidence-based Policy on Gender-affirming Medical Interventions, prepared for the Oregon Health Evidence Review Commission. It was cancelled before publication. it was obtained through a public records request.
Astrometric calibration and performance of the Dark Energy Camera
Creators: name: Bernstein, G. M.
name: Armstrong, R.
name: Plazas, A. A.
name: Walker, A. R.
name: Abbott, T. M. C.
name: Allam, S.
name: Bechtol, K.
name: Benoit-Lévy, A.
name: Brooks, D.
name: Burke, D. L.
name: Rosell, A. Carnero
name: Kind, M. Carrasco
name: Carretero, J.
name: Cunha, C. E.
name: da Costa, L. N.
name: DePoy, D. L.
name: Desai, S.
name: Diehl, H. T.
name: Eifler, T. F.
name: Fernandez, E.
name: Fosalba, P.
name: Frieman, J.
name: García-Bellido, J.
name: Gerdes, D. W.
name: Gruen, D.
name: Gruendl, R. A.
name: Gschwend, J.
name: Gutierrez, G.
name: Honscheid, K.
name: James, D. J.
name: Kent, S.
name: Krause, E.
name: Kuehn, K.
name: Kuropatkin, N.
name: Li, T. S.
name: Maia, M. A. G.
name: March, M.
name: Marshall, J. L.
name: Menanteau, F.
name: Miquel, R.
name: Ogando, R. L. C.
name: Reil, K.
name: Roodman, A.
name: Rykoff, E. S.
name: Sanchez, E.
name: Scarpine, V.
name: Schindler, R.
name: Schubnell, M.
name: Sevilla-Noarbe, I.
name: Smith, M.
name: Smith, R. C.
name: Soares-Santos, M.
name: Sobreira, F.
name: Suchyta, E.
name: Swanson, M. E. C.
name: Tarle, G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We characterize the ability of the Dark Energy Camera (DECam) to perform relative astrometry across its 500~Mpix, 3 deg^2 science field of view, and across 4 years of operation. This is done using internal comparisons of ~4x10^7 measurements of high-S/N stellar images obtained in repeat visits to fields of moderate stellar density, with the telescope dithered to move the sources around the array. An empirical astrometric model includes terms for: optical distortions; stray electric fields in the CCD detectors; chromatic terms in the instrumental and atmospheric optics; shifts in CCD relative positions of up to ~10 um when the DECam temperature cycles; and low-order distortions to each exposure from changes in atmospheric refraction and telescope alignment. Errors in this astrometric model are dominated by stochastic variations with typical amplitudes of 10-30 mas (in a 30 s exposure) and 5-10 arcmin coherence length, plausibly attributed to Kolmogorov-spectrum atmospheric turbulence. The size of these atmospheric distortions is not closely related to the seeing. Given an astrometric reference catalog at density ~0.7 arcmin^{-2}, e.g. from Gaia, the typical atmospheric distortions can be interpolated to 7 mas RMS accuracy (for 30 s exposures) with 1 arcmin coherence length for residual errors. Remaining detectable error contributors are 2-4 mas RMS from unmodelled stray electric fields in the devices, and another 2-4 mas RMS from focal plane shifts between camera thermal cycles. Thus the astrometric solution for a single DECam exposure is accurate to 3-6 mas (0.02 pixels, or 300 nm) on the focal plane, plus the stochastic atmospheric distortion.
description: Submitted to PASP
The securitization of secrecy: the role of leaks in determining the function of secrecy in international relations
Creators: name: Conner, Sean
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The recent events of low-level government employees, disclosing secret information to both traditional and non-traditional media publishers has been responded to by the Obama administration with an increase in the number of prosecutions being executed.Such events have led to questions concerning the role of secrecy in International Relations. Using the Copenhagen School’s conceptual framework of securitization, and Gibbs’ theoretical approaches of the use of secrecy in general in International Relations, this thesis discusses to what extent unauthorized disclosures reveal information about the role secrecy plays in the International Sphere. The securitizing moves of government agencies in seeking to prevent whistleblowers and leakers from disclosing confidential information, and the reverse attempts of privacy advocates and tech companies attempting to securitize the issue of online privacy, demonstrate how this issue has moved into cyberspace. Individualsand organizations on both sides of the debate have implemented extraordinary measures in their efforts to securitize the issue. Securitization theory provides the means and Gibbs’ theoretical approaches provide the motives as to why secrecy is of such importance between governments and competing agencies. After discussing the issue, this thesis concludes that unauthorized disclosures tend to support the notion that secrecy is a valuable tool, not to prevent external enemies from understanding a state’s capabilities, but rather to prevent internal agencies from disrupting the executive branch’s objectives. As such, secrecy can be viewed as a tool to concentrate power in the elite, away from the general population, contrary to the ideals of democracy.
Cost-efficiency analysis and expanded treatment access modeling of conversion to rituximab biosimilars from reference rituximab in Jordan
Creators: name: Halawah, Hala H
name: Alkhatib, Nimer S
name: Almutairi, Abdulaali R
name: Saleh, Mohammad
name: Halloush, Shiraz S
name: Rashdan, Omar
name: Masadh, Lama
name: Abusara, Osama H
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy
subject: Hematology

description: To assess the cost-efficiency and expanded access of three rituximab biosimilars versus the reference rituximab from the perspective of the Jordanian national health payer. A 1-year cost-efficiency and expanded access model of conversion from reference rituximab (Mabthera) to the approved biosimilars (Truxima, Rixathon, and Tromax) to assess five metrics: total annual cost to treat a hypothetical patient; head-to-head cost comparison; changes in patients’ access to rituximab; number-needed-to-convert (NNC) to provide an additional 10 patients access to a rituximab treatment; and relative amount of Jordanian Dinar (JOD) spent on rituximab options. The model included rituximab doses at 100mg/10ml and 500mg/50ml and considered both cost-saving and cost-wastage scenarios. Costs of treatments were based on fiscal year 2022 tender prices received by the Joint Procurement Department (JPD). Rixathon was associated with the lowest average annual cost per patient (JOD2,860) across all six indications among all rituximab comparators, followed by Truxima (JOD4,240), Tromax (JOD4,365) and reference Mabthera (JOD11,431). The highest percentage of patient access to rituximab treatment (321%) was achieved when switching patients from Mabthera to Rixathon in the RA and PV indications. At four patients, Rixathon was associated with the lowest NNC to provide an additional 10 patients access to a rituximab treatment. For each JOD1 spent on Rixathon, an additional JOD3.21 must be spent on Mabthera, an additional JOD0.55 on Tromax, and an additional JOD0.53 on Truxima. Rituximab biosimilars were associated with cost savings in all approved indications in Jordan compared to reference rituximab. Rixathon was associated with the lowest annual cost, the highest percentage of expanded patient access for all six indications, and the lowest NNC providing 10 additional patients with access.
HARPS-N high spectral resolution observations of Cepheids I. The Baade-Wesselink projection factor of δ Cep revisited
Creators: name: Nardetto, N.
name: Poretti, E.
name: Rainer, M.
name: Fokin, A.
name: Mathias, P.
name: Anderson, R. I.
name: Gallenne, A.
name: Gieren, W.
name: Graczyk, D.
name: Kervella, P.
name: Mérand, A.
name: Mourard, D.
name: Neilson, H.
name: Pietrzynski, G.
name: Pilecki, B.
name: Storm, J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The projection factor p is the key quantity used in the Baade-Wesselink (BW) method for distance determination; it converts radial velocities into pulsation velocities. Several methods are used to determine p, such as geometrical and hydrodynamical models or the inverse BW approach when the distance is known. We analyze new HARPS-N spectra of delta Cep to measure its cycle-averaged atmospheric velocity gradient in order to better constrain the projection factor. We first apply the inverse BW method to derive p directly from observations. The projection factor can be divided into three subconcepts: (1) a geometrical effect (p0); (2) the velocity gradient within the atmosphere (fgrad); and (3) the relative motion of the optical pulsating photosphere with respect to the corresponding mass elements (fo-g). We then measure the fgrad value of delta Cep for the first time. When the HARPS-N mean cross-correlated line-profiles are fitted with a Gaussian profile, the projection factor is pcc-g = 1.239 +/- 0.034(stat) +/- 0.023(syst). When we consider the different amplitudes of the radial velocity curves that are associated with 17 selected spectral lines, we measure projection factors ranging from 1.273 to 1.329. We find a relation between fgrad and the line depth measured when the Cepheid is at minimum radius. This relation is consistent with that obtained from our best hydrodynamical model of delta Cep and with our projection factor decomposition. Using the observational values of p and fgrad found for the 17 spectral lines, we derive a semi-theoretical value of fo-g. We alternatively obtain fo-g = 0.975+/-0.002 or 1.006+/-0.002 assuming models using radiative transfer in plane-parallel or spherically symmetric geometries, respectively. The new HARPS-N observations of delta Cep are consistent with our decomposition of the projection factor.
description: 11 pages, accepted in A&A
MUSTAQILLIKDAN KEYINGI DAVRDA XORAZMDA TEATR SANʼATI: RIVOJLANISH, MUAMMOLAR VA ISTIQBOLLARI
Creators: name: Saotboyev, Raxmatjon
Publisher: name: Zenodo
Year: 2025

description: Oʻzbekiston mustaqillikka erishgach, madaniyat va sanʼat sohalarida yangi bosqich boshlandi. Xorazm mintaqasi ham bu jarayonda oʻziga xos oʻrinni egalladi. Mustaqillikdan keyingi davrda Xorazmda teatr sanʼati nafaqat anʼanaviy shakllarni saqlab qoldi, balki yangicha uslublar va yoʻnalishlar bilan ham boyidi. Biroq, bu davrda teatr sanʼati rivojida bir qator muammolar ham mavjud boʻlib, ularning bartaraf etilishi uchun chora-tadbirlar koʻrilmoqda.
Economic and clinical burden of managing transfusion-dependent β-thalassemia in the United States
Creators: name: Udeze, Chuka
name: Evans, Kristin A.
name: Yang, Yoojung
name: Lillehaugen, Timothy
name: Manjelievskaia, Janna
name: Mujumdar, Urvi
name: Li, Nanxin
name: Andemariam, Biree
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: To describe clinical complications, treatment use, healthcare resource utilization (HCRU), and costs among patients with transfusion-dependent β-thalassemia (TDT) in the United States. Merative MarketScan Databases were used to identify patients with β-thalassemia between 1 March 2010, and 1 March 2019. Patients were eligible for inclusion with ≥1 inpatient claim or ≥2 outpatient claims for β-thalassemia and ≥8 red blood cell transfusions (RBCTs) during any 12-month period after and including the date of the first qualifying β-thalassemia diagnosis code. Matched controls consisted of individuals without β-thalassemia. Clinical and economic outcomes of patients were assessed during ≥12 months of follow-up, defined as the period from the index date (i.e. the first RBCT) to either the end of continuous enrollment in benefits, inpatient death, or 1 March 2020. Overall, 207 patients with TDT and 1035 matched controls were identified. Most patients received iron chelation therapy (ICT) (91.3%), with a mean of 12.1 (standard deviation [SD] = 10.3) ICT claims per-patient-per-year (PPPY). Many also received RBCTs, with a mean of 14.2 (SD = 4.7) RBCTs PPPY. TDT was associated with higher annual ($137,125) and lifetime ($7.1 million) healthcare costs vs. matched controls ($4183 and $235,000, respectively). Annual costs were driven by ICT (52.1%) and RBCT use (23.6%). Patients with TDT had 7-times more total outpatient visits/encounters, 3-times more prescriptions, and 33-times higher total annual costs than matched controls. This analysis may underestimate the burden of TDT, as indirect healthcare costs (e.g. absenteeism, presenteeism, etc.) were not included. Results may not be generalizable to patients excluded from this analysis, including those with other types of insurance or without insurance. Patients with TDT have high HCRU and direct healthcare costs. Treatments that eliminate the need for RBCTs could reduce the clinical and economic burden of managing TDT.
Additional file 7: Figure S7. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Creators: name: Yun, Seung
name: Donghoon Kim
name: Sangjune Kim
name: SangMin Kim
name: Senthilkumar Karuppagounder
name: Seung-Hwan Kwon
name: Saebom Lee
name: Tae-In Kam
name: Suhyun Lee
name: Sangwoo Ham
name: Park, Jae
name: Valina Dawson
name: Dawson, Ted
name: Yunjong Lee
name: Ko, Han
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Developmental Biology

description: Neuron specific AAV5-hGBA overexpression in SNpc region. a Vector design of AAV5 hGBA. b Representative immunofluorescent images of GFP (green, injection marker), GFAP (red, astrocyte, non-neuronal marker), Tuj1 (Violet, neuronal marker), and DAPI (Blue). (PDF 4671 kb)
The impact of vaccination and outpatient treatment on the economic burden of Covid-19 in the United States omicron era: a systematic literature review
Creators: name: Pierre, Vicki
name: Draica, Florin
name: Di Fusco, Manuela
name: Yang, Jingyan
name: Nunez-Gonzalez, Solange
name: Kamar, Joanna
name: Lopez, Santiago
name: Moran, Mary M.
name: Nguyen, Jennifer
name: Alvarez, Piedad
name: Cha-Silva, Ashley
name: Gavaghan, Meghan
name: Yehoshua, Alon
name: Stapleton, Naomi
name: Burnett, Heather
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: To identify and synthesize evidence regarding how coronavirus disease 2019 (COVID-19) interventions, including vaccines and outpatient treatments, have impacted healthcare resource use (HCRU) and costs in the United States (US) during the Omicron era. A systematic literature review (SLR) was performed to identify articles published between 1 January 2021 and 10 March 2023 that assessed the impact of vaccination and outpatient treatment on costs and HCRU outcomes associated with COVID-19. Screening was performed by two independent researchers using predefined inclusion/exclusion criteria. Fifty-eight unique studies were included in the SLR, of which all reported HCRU outcomes, and one reported costs. Overall, there was a significant reduction in the risk of COVID-19-related hospitalization for patients who received an original monovalent primary series vaccine plus booster dose vs. no vaccination. Moreover, receipt of a booster vaccine was associated with a lower risk of hospitalization vs. primary series vaccination. Evidence also indicated a significantly reduced risk of hospitalizations among recipients of nirmatrelvir/ritonavir (NMV/r), remdesivir, sotrovimab, and molnupiravir compared to non-recipients. Treated and/or vaccinated patients also experienced reductions in intensive care unit (ICU) admissions, length of stay, and emergency department (ED)/urgent care clinic encounters. The identified studies may not represent unique patient populations as many utilized the same regional/national data sources. Synthesis of the evidence was also limited by differences in populations, outcome definitions, and varying duration of follow-up across studies. Additionally, significant gaps, including HCRU associated with long COVID and various high-risk populations and cost data, were observed. Despite evidence gaps, findings from the SLR highlight the significant positive impact that vaccination and outpatient treatment have had on HCRU in the US, including periods of Omicron predominance. Continued research is needed to inform clinical and policy decision-making in the US as COVID-19 continues to evolve as an endemic disease.