cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Made-to-Measure Modelling of Globular Clusters
Creators: name: Webb, Jeremy J.
name: Hunt, Jason A. S.
name: Bovy, Jo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first application of the made-to-measure method for modelling dynamical systems to globular clusters. Through the made-to-measure algorithm, the masses of individual particles within a model cluster are adjusted while the system evolves forward in time via a gravitational $N$-body code until the model cluster is able to reproduce select properties of an observed cluster. The method is first applied to observations of mock isotropic and anisotropic clusters while fitting against the cluster's three dimensional or projected density profile, density weighted mean-squared velocity profile, or its density profile with individual mean-squared velocity profiles. We find that a cluster's three-dimensional density profile can easily be reproduced by the made-to-measure method, with minor discrepancies in the outer regions if fitting against a cluster's projected surface density or projected kinematic properties. If an observed cluster is anisotropic, only fitting against the cluster's density profile and individual mean-squared velocity profiles will fully recover the full degree of anisotropy. Partial anisotropy can be recovered as long as two kinematic properties are included in the fit. We further apply the method to observations of the Galactic globular cluster M4 and generate a complete six-dimensional representation of the cluster that reproduces observations of its surface density profile, mean-squared proper motion velocity profile, and mean-squared line of sight velocity profile. The M2M method predicts M4 is primarily isotropic with a mass of $9.2 \pm 0.4 \times 10^4\, M_{\odot}$ and a half-mass radius of $3.7 \pm 0.1$ pc.
description: 11 pages, 10 figures, submitted to MNRAS for publication
title: S.O.S Mamans en Détresse
title: comment venir en aide aux mamans dont l'enfant souffre de leucémie ?
titleType: Subtitle
Creators: name: Conne, Margaux
name: Pattaroni, Pauline
Publisher: name: Unknown
Year: 0
Subjects: subject: ACCOMPAGNEMENT
subject: MERE
subject: RELATION MERE-ENFANT
subject: ENFANT , CANCER
subject: LEUCEMIE

description: Dans le cadre de ce travail de Bachelor, nous souhaitions toutes deux nous intéresser au domaine de la pédiatrie. Nos recherches nous ont fait choisir la leucémie, un des cancers les plus fréquemment diagnostiqués chez les enfants. Beaucoup d’études s’intéressent déjà au vécu de ceux-ci, c’est pourquoi nous avons décidé d’explorer celui de la maman, qui joue un rôle important dans les soins donnés à l’enfant.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
title: Adulte en fin de vie
title: des pistes pour l'accompagnement spirituel infirmier
titleType: Subtitle
Creators: name: Chenevas-Paule, Rémi
Publisher: name: Unknown
Year: 0
Subjects: subject: ADULTE
subject: FIN DE VIE
subject: ACCOMPAGNEMENT SPIRITUEL
subject: SOINS PALLIATIFS

description: Cette revue de littérature explore les données de plusieurs articles scientifiques afin de répondre à la question de recherche suivante : « Quelles interventions les infirmiers peuvent-ils mettre en place pour favoriser le processus d'auto-transcendance et le bien-être spirituel des adultes en fin de vie ? »
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Single-cell RNA-sequencing of 4CL and 4CL/N/B cells.
Creators: name: 贾雯淇
Publisher: name: CNGB
Year: 2023
Subjects: Transcriptome or Gene expression
Other
Human embryonic stem cells

description: We have generated naive cells from ESCs and MYCN/BCL2 overexpressing ESCs cultured in 4CL culture system (named 4CL and 4CL/N/B). Single-cell RNA sequencing was used to analyze the 4CL gene expression pattern and the effect of MYCN/BCL2 overexpression on cell pluripotency and cell cycle. We observed 4CL were positioned homogeneously closer to embryonic day5 (E5) of the human pre-implantation blastocyst. 4CL/N/B ESCs had a transcriptional profile enriched in naive pluripotency genes similar to 4CL ESCs. Besides, enrichment of cell cycle related gene ontology terms for upregulated genes in 4CL/N/B and a higher percentage of cells entering the G2/M phase in 4CL/N/B ESCs compared to 4CL alone in this analysis.
Fractal analysis of the galaxy distribution in the redshift range 0.45 < z < 5.0
Creators: name: Conde-Saavedra, G.
name: Iribarrem, A.
name: Ribeiro, Marcelo B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Evidence is presented that the galaxy distribution can be described as a fractal system in the redshift range of the FDF galaxy survey. The fractal dimension $D$ was derived using the FDF galaxy volume number densities in the spatially homogeneous standard cosmological model with $Ω_{m_0}=0.3$, $Ω_{Λ_0}=0.7$ and $H_0=70 \; \mbox{km} \; {\mbox{s}}^{-1} \; {\mbox{Mpc}}^{-1}$. The ratio between the differential and integral number densities $γ$ and $γ^\ast$ obtained from the red and blue FDF galaxies provides a direct method to estimate $D$, implying that $γ$ and $γ^\ast$ vary as power-laws with the cosmological distances. The luminosity distance $d_{\scriptscriptstyle L}$, galaxy area distance $d_{\scriptscriptstyle G}$ and redshift distance $d_z$ were plotted against their respective number densities to calculate $D$ by linear fitting. It was found that the FDF galaxy distribution is characterized by two single fractal dimensions at successive distance ranges. Two straight lines were fitted to the data, whose slopes change at $z \approx 1.3$ or $z \approx 1.9$ depending on the chosen cosmological distance. The average fractal dimension calculated using $γ^\ast$ changes from $\langle D \rangle=1.4^{\scriptscriptstyle +0.7}_{\scriptscriptstyle -0.6}$ to $\langle D \rangle=0.5^{\scriptscriptstyle +1.2}_{\scriptscriptstyle -0.4}$ for all galaxies, and $D$ decreases as $z$ increases. Small values of $D$ at high $z$ mean that in the past galaxies were distributed much more sparsely and the large-scale galaxy structure was then possibly dominated by voids. Results of Iribarrem et al. (2014, arXiv:1401.6572) indicating similar fractal features with $\langle D \rangle =0.6 \pm 0.1$ in the far-infrared sources of the Herschel/PACS evolutionary probe (PEP) at $1.5 \lesssim z \lesssim 3.2$ are also mentioned.
description: LaTex, 15 pages, 28 figures, 4 tables. To appear in "Physica A"
title: L'agitation des personnes âgées atteintes de démence à l'hôpital
title: un défi pour les soins infirmiers
titleType: Subtitle
Creators: name: Chabloz, Adélie
name: Roy, Amélie
Publisher: name: Unknown
Year: 0
Subjects: subject: PERSONNE AGEE
subject: DEMENCE
subject: AGITATION
subject: HOSPITALISATION

description: La population mondiale est vieillissante et le nombre de personnes âgées atteintes de démence (PAD) va doubler d’ici à 2030. Grâce aux progrès de la médecine, l’espérance de vie augmente et les PAD fréquentent de plus en plus les services de soins aigus à cause de pathologies somatiques. Lors des hospitalisations, les troubles du comportement sont fréquents et l’agitation pose problème à la réalisation des soins.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
In silico study of liquid crystalline phases formed by bent-shaped molecules with excluded-volume type interactions
Creators: name: Kubala, Piotr
name: Tomczyk, Wojciech
name: Cieśla, Michał
Publisher: name: arXiv
Year: 2021
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We have numerically studied a liquid composed of achiral, bent-shaped molecules built of tangent spheres. The system is known to spontaneously break mirror symmetry, as it forms a macroscopically chiral, twist-bend nematic phase [Phys. Rev. Lett. 115, 147801 (2015)]. Here, we have examined the full phase diagram of such liquid and observed several phases characterized by orientational and/or translational ordering of molecules. Apart from conventional nematic, smectic A, and the above-mentioned twist-bend nematic phase, we have identified antiferroelectric smectic A phase. For large densities and a high degree of molecule's structural bend, another smectic phase emerged, where the polarization vector rotates within a single smectic layer. These results were confirmed using both Monte Carlo and molecular dynamics simulations.
title: Papa aussi est important !
title: expérience de la prématurité du point de vue des pères et prise en charge infirmière
titleType: Subtitle
Creators: name: Butty, Natacha
name: Touili Boillat, Salma
Publisher: name: Unknown
Year: 0
Subjects: subject: RELATION PERE-ENFANT
subject: SOINS INTENSIFS
subject: NEONATOLOGIE
subject: PREMATURE

description: « En fonction du sens que le père donne à son expérience de la paternité, comment la prise en charge infirmière peut-elle favoriser l’adaptation du père durant l’hospitalisation de son enfant prématuré en soins intensifs de néonatologie ? »
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
A Novel, Multifunctional c-Cbl Binding Protein in Insulin Receptor Signaling in 3T3-L1 Adipocytes
Creators: name: Saltiel, Alan R.
name: Kay, Brian K.
name: Hoffman, Noah G.
name: Ribon, Vered
name: Printen, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The protein product of the c-Cbl proto-oncogene is prominently tyrosine phosphorylated in response to insulin in 3T3-L1 adipocytes and not in 3T3-L1 fibroblasts. After insulin-dependent tyrosine phosphorylation, c-Cbl specifically associates with endogenous c-Crk and Fyn. These results suggest a role for tyrosine-phosphorylated c-Cbl in 3T3-L1 adipocyte activation by insulin. A yeast two-hybrid cDNA library prepared from fully differentiated 3T3-L1 adipocytes was screened with full-length c-Cbl as the target protein in an attempt to identify adipose-specific signaling proteins that interact with c-Cbl and potentially are involved in its tyrosine phosphorylation in 3T3-L1 adipocytes. Here we describe the isolation and the characterization of a novel protein that we termed CAP for c-Cbl-associated protein. CAP contains a unique structure with three adjacent Src homology 3 (SH3) domains in the C terminus and a region showing significant sequence similarity with the peptide hormone sorbin. Both CAP mRNA and proteins are expressed predominately in 3T3-L1 adipocytes and not in 3T3-L1 fibroblasts. CAP associates with c-Cbl in 3T3-L1 adipocytes independently of insulin stimulation in vivo and in vitro in an SH3-domain-mediated manner. Furthermore, we detected the association of CAP with the insulin receptor. Insulin stimulation resulted in the dissociation of CAP from the insulin receptor. Taken together, these data suggest that CAP represents a novel c-Cbl binding protein in 3T3-L1 adipocytes likely to participate in insulin signaling.
Ash1, a Daughter Cell-Specific Protein, Is Required for Pseudohyphal Growth ofSaccharomyces cerevisiae
Creators: name: Errede, Beverly
name: Chandarlapaty, Sarat
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Ash1 (for asymmetric synthesis ofHO) was first uncovered in genetic screens that revealed its role in mating-type switching. Ash1 preventsHOexpression in daughter cells. Because Ash1 has a zinc finger-like domain related to that of the GATA family of transcription factors, it presumably acts by repressingHOtranscription. Nonswitching diploid cells also express Ash1, suggesting it could have functions in addition to regulation ofHOexpression. We show here that Ash1 has an essential function for pseudohyphal growth. Our epistasis analyses are consistent with the deduction that Ash1 acts separately from the mitogen-activated protein kinase cascade and Ste12. Similarly to the case in yeast form cells, Ash1 is asymmetrically localized to the nuclei of daughter cells during pseudohyphal growth. This asymmetric localization reveals that there is a previously unsuspected daughter cell-specific function necessary for pseudohyphal growth.
Spatial scRNA-seq of aqueous humor circulatory system in human eyes
Creators: name: 宋朝娜(Monica)
Publisher: name: CNGB
Year: 2023
Subjects: Transcriptome or Gene expression
Multiisolate
Medical

description: Glaucoma is one of the leading causes of irreversible blindness worldwide, which manifests elevated intraocular pressure (IOP) in clinic. The dynamic changes of IOP virtually are the physical equilibrium between the production and drainage of aqueous humor (AH). However, due to incomplete understanding of the AH circulatory system, the more advanced and effective treatment options for glaucoma still face challenges. To gain insights into the cell elements and function heterogeneity involved in the AH circulatory system, we used spatial enhanced-resolution omics sequencing (Stereo-Seq).
CDC42 and FGD1 Cause Distinct Signaling and Transforming Activities
Creators: name: Gorski, Jerome L.
name: Whitehead, Ian P.
name: Der, Channing J.
name: Abe, Karon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Activated forms of different Rho family members (CDC42, Rac1, RhoA, RhoB, and RhoG) have been shown to transform NIH 3T3 cells as well as contribute to Ras transformation. Rho family guanine nucleotide exchange factors (GEFs) (also known as Dbl family proteins) that activate CDC42, Rac1, and RhoA also demonstrate oncogenic potential. The faciogenital dysplasia gene product, FGD1, is a Dbl family member that has recently been shown to function as a CDC42-specific GEF. Mutations within theFGD1locus cosegregate with faciogenital dysplasia, a multisystemic disorder resulting in extensive growth impairments throughout the skeletal and urogenital systems. Here we demonstrate that FGD1 expression is sufficient to cause tumorigenic transformation of NIH 3T3 fibroblasts. Although both FGD1 and constitutively activated CDC42 cooperated with Raf and showed synergistic focus-forming activity, both quantitative and qualitative differences in their functions were seen. FGD1 and CDC42 also activated common nuclear signaling pathways. However, whereas both showed comparable activation of c-Jun, CDC42 showed stronger activation of serum response factor and FGD1 was consistently a better activator of Elk-1. Although coexpression of FGD1 with specific inhibitors of CDC42 function demonstrated the dependence of FGD1 signaling activity on CDC42 function, FGD1 signaling activities were not always consistent with the direct or exclusive stimulation of CDC42 function. In summary, FGD1 and CDC42 signaling and transformation are distinct, thus suggesting that FGD1 may be mediating some of its biological activities through non-CDC42 targets.
The Binomial Theorem and motivic classes of universal quasi-split tori
Creators: name: Bergh, Daniel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14A20, 14L10, 14G27, 14M20

description: Taking symmetric powers of varieties can be seen as a functor from the category of varieties to the category of varieties with an action by the symmetric group. We study a corresponding map between the Grothendieck groups of these categories. In particular, we derive a binomial formula and use it to give explicit expressions for the classes of universal quasi-split tori in the equivariant Grothendieck group of varieties.
Prévenir le risque suicidaire chez les requérants d'asile
Creators: name: Bochud, Laura
name: Stabile, Vanessa
name: Tâche, Déborah
Publisher: name: Unknown
Year: 0
Subjects: subject: SUICIDE
subject: RISQUE
subject: DROIT D'ASILE
subject: INTERCULTURALITE

description: Actuellement, la migration est au centre des médias. Nous pouvons lire dans les journaux que des requérants d'asile se suicident car leurs aspects bio-physique, psychologique, développemental, social, culturel et spirituel ne sont pas optimaux. Les infirmières de consultation sont les premières à intervenir sur le risque suicidaire dans cette population. C'est pourquoi le choix de notre question de recherche s'est porté sur : comment l'infirmière de première ligne peut prévenir le risque suicidaire chez les requérants d'asile masculins ?
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Destabilization of Yeast Micro- and Minisatellite DNA Sequences by Mutations Affecting a Nuclease Involved in Okazaki Fragment Processing (rad27) and DNA Polymerase δ (pol3-t)
Creators: name: Resnick, Michael A.
name: Petes, Thomas D.
name: Stefanovic, Lela
name: Tran, Hiep T.
name: Gordenin, Dmitry A.
name: Kokoska, Robert J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: We examined the effects of mutations in theSaccharomyces cerevisiae RAD27(encoding a nuclease involved in the processing of Okazaki fragments) andPOL3(encoding DNA polymerase δ) genes on the stability of a minisatellite sequence (20-bp repeats) and microsatellites (1- to 8-bp repeat units). Both therad27andpol3-tmutations destabilized both classes of repeats, although the types of tract alterations observed in the two mutant strains were different. The tract alterations observed inrad27strains were primarily additions, and those observed inpol3-tstrains were primarily deletions. Measurements of the rates of repetitive tract alterations in strains with bothrad27andpol3-tindicated that the stimulation of microsatellite instability byrad27was reduced by the effects of thepol3-tmutation. We also found thatrad27andpol3-01(an allele carrying a mutation in the “proofreading” exonuclease domain of DNA polymerase δ) mutations were synthetically lethal.
title: Etat confusionnel aigu chez l'enfant
title: un phénomène méconnu dans la discipline infirmière
titleType: Subtitle
Creators: name: Blunschi, Florence
name: Cortellini, Lara
name: Velo, Maxime
Publisher: name: Unknown
Year: 0
Subjects: subject: DELIRIUM
subject: DIAGNOSTIC
subject: TRAITEMENT
subject: ENFANT
subject: PEDIATRIE
subject: PSYCHIATRIE
subject: ANESTHESIE
subject: ROLE INFIRMIER

description: Cette revue de littérature s’inscrit dans le cadre de la validation finale de la formationBachelor of Science en soins infirmiers. Nous avons choisis le thème de l’état confusionnel aigu ou délirium chez l’enfant car c’est un phénomène encore méconnu qui peut avoir des conséquences sur la récupération de l’enfant après l’anesthésie. Nous nous sommes donc intéressés au rôle de l’infirmière dans la prévention, la détection et le traitement de cette pathologie.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Agent-based model with asymmetric trading and herding for complex financial systems
Creators: name: Chen, Jun-jie
name: Zheng, Bo
name: Tan, Lei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Finance (q-fin.ST)
subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: Background: For complex financial systems, the negative and positive return-volatility correlations, i.e., the so-called leverage and anti-leverage effects, are particularly important for the understanding of the price dynamics. However, the microscopic origination of the leverage and anti-leverage effects is still not understood, and how to produce these effects in agent-based modeling remains open. On the other hand, in constructing microscopic models, it is a promising conception to determine model parameters from empirical data rather than from statistical fitting of the results. Methods: To study the microscopic origination of the return-volatility correlation in financial systems, we take into account the individual and collective behaviors of investors in real markets, and construct an agent-based model. The agents are linked with each other and trade in groups, and particularly, two novel microscopic mechanisms, i.e., investors' asymmetric trading and herding in bull and bear markets, are introduced. Further, we propose effective methods to determine the key parameters in our model from historical market data. Results: With the model parameters determined for six representative stock-market indices in the world respectively, we obtain the corresponding leverage or anti-leverage effect from the simulation, and the effect is in agreement with the empirical one on amplitude and duration. At the same time, our model produces other features of the real markets, such as the fat-tail distribution of returns and the long-term correlation of volatilities. Conclusions: We reveal that for the leverage and anti-leverage effects, both the investors' asymmetric trading and herding are essential generation mechanisms. These two microscopic mechanisms and the methods for the determination of the key parameters can be applied to other complex systems with similar asymmetries.
description: 17 pages, 6 figures
L’importance du rôle infirmier dans la gestion de la douleur post-opératoire chez l'enfant
Creators: name: Barth, Julie
name: Brevard, Manon
name: Reymond, Céline
Publisher: name: Unknown
Year: 0
Subjects: subject: DOULEUR
subject: CHIRURGIE
subject: ENFANT
subject: PEDIATRIE

description: Très nombreuses sont les recherches démontrant que les enfants continuent d’expérimenter des douleurs modérées à sévères durant leurs hospitalisations. Dans la gestion de la douleur, l’infirmière a une place centrale. C’est sur la base de sa réflexion et des moyens qu’elle a à disposition, qu’une diminution rapide et efficace de la douleur d’un enfant pourra être perçue.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
title: Communiquer avec les patients intubés
title: un défi pour les soignants aux soins intensifs
titleType: Subtitle
Creators: name: Babel, Chloé
name: Zampieri, Elena
Publisher: name: Unknown
Year: 0
Subjects: subject: COMMUNICATION
subject: PATIENT
subject: SOINS INTENSIFS

description: Plusieurs études faites au cours des dernières années ont montré que les infirmières travaillant aux soins intensifs sont confrontées à des difficultés de communication avec les patients intubés. Ces études démontrent l’efficacité des outils complémentaires de communication destinés à améliorer la communication avec les patients non-communicants, cependant peu sont mises en place sur le terrain des soins intensifs.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
title: La transition pour les jeunes atteints de mucoviscidose d'un service pédiatrique à un service adulte
title: quelles interventions infirmières peuvent favoriser cette transition ?
titleType: Subtitle
Creators: name: Avondo, Jennifer
name: Kovacs, Marion
name: Symons, Rébecca
Publisher: name: Unknown
Year: 0
Subjects: subject: MUCOVISCIDOSE
subject: ROLE INFIRMIER
subject: PEDIATRIE

description: Les soins pour les patients atteints de mucoviscidose, ayant évolué ces dernières années, ont permis une espérance de vie considérablement plus longue. De ce fait, les jeunes patients qui atteignent l’adolescence sont dès lors transférés dans un service adulte. Ce processus nécessite un programme de transition adapté aux besoins spécifiques de l’adolescent qui vit une double transition. En vue de ce passage à l’âge adulte et du changement d’environnement, il est nécessaire pour les infirmières d’acquérir des compétences particulières pour l’accompagner dans cette période transitionnelle délicate. Peu de programmes de transition existent en Suisse. Le but de notre travail est de faire ressortir des interventions optimales que l’infirmière peut mettre en place lors de la transition d’un service de pédiatrie à un service adulte.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Deciphering signatures of Bardeen black holes from the observed quasi-periodic oscillations
Creators: name: Banerjee, Indrani
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Quasi-periodic oscillations (QPOs) observed in the power spectrum of black holes are unique observational probes to the background spacetime since they can be directly related to the timescales associated with the motion of matter orbiting in the vicinity of the black hole horizon. In this regard, the high frequency QPOs (HFQPOs) are particularly interesting as they occur in commensurable pairs, the most common ratio being the 3:2 twin peak QPOs. The theoretical models which aim to explain these QPOs express the observed frequencies in terms of the epicyclic motion of test particles in a given background spacetime. In this work we study the signatures of Bardeen spacetime from the observed QPOs in the black hole power spectrum. Bardeen black holes are rotating, regular black holes with a magnetic monopole charge. Such regular backgrounds are theoretically interesting as they can potentially evade the curvature singularity, otherwise unavoidable in general relativistic black holes. We perform a chi-square analysis by comparing the available observations of the quasi-periodic oscillations from black hole sources with the relevant theoretical models and note that the Kerr black holes in general relativity are observationally more favored compared to black holes with a monopole charge. Our analysis reveals that black holes with very high monopole charge are disfavored from QPO related observations.
description: 23 pages, 2 figures
Topological fine structure of smectic grain boundaries and tetratic disclination lines within three-dimensional smectic liquid crystals
Creators: name: Monderkamp, Paul A.
name: Wittmann, René
name: Vrugt, Michael te
name: Voigt, Axel
name: Wittkowski, Raphael
name: Löwen, Hartmut
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mathematical Physics (math-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Observing and characterizing the complex ordering phenomena of liquid crystals subjected to external constraints constitutes an ongoing challenge for chemists and physicists alike. To elucidate the delicate balance appearing when the intrinsic positional order of smectic liquid crystals comes into play, we perform Monte-Carlo simulations of rod-like particles in a range of cavities with a cylindrical symmetry. Based on recent insights into the topology of smectic orientational grain boundaries in two dimensions, we analyze the emerging three-dimensional defect structures from the perspective of tetratic symmetry. Using an appropriate three-dimensional tetratic order parameter constructed from the Steinhardt order parameters, we show that those grain boundaries can be interpreted as a pair of tetratic disclination lines that are located on the edges of the nematic domain boundary. Thereby, we shed light on the fine structure of grain boundaries in three-dimensional confined smectics.
title: Belle malgré tout
title: stratégies de coping des femmes vivant l'alopécie suite à une chimiothérapie
titleType: Subtitle
Creators: name: Aubry, Mathilde
name: Wüthrich, Julie
Publisher: name: Unknown
Year: 0
Subjects: subject: IMAGE DE SOI
subject: CANCER
subject: SEIN
subject: FEMME

description: L’alopécie est un des effets secondaires les plus traumatisants de la chimiothérapie et a un impact important sur la qualité de vie des femmes. Malheureusement, peu d’interventions sont mises en place afin d’aider ces personnes à faire face à cette expérience difficile qui est souvent sous-estimée par les professionnels de la santé.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Interaction of Tumor Necrosis Factor Receptor-Associated Factor Signaling Proteins with the Latent Membrane Protein 1 PXQXT Motif Is Essential for Induction of Epidermal Growth Factor Receptor Expression
Creators: name: Cheshire, Jeanette L.
name: Miller, William E.
name: Raab-Traub, Nancy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The Epstein-Barr virus latent membrane protein 1 (LMP1) oncoprotein causes multiple cellular changes, including induction of epidermal growth factor receptor (EGFR) expression and activation of the NF-κB transcription factor. LMP1 and the cellular protein CD40, which also induces EGFR expression, interact with the tumor necrosis factor receptor-associated factor (TRAF) proteins. The LMP1 carboxy-terminal activation region 1 signaling domain interacts specifically with the TRAFs and is essential for EGFR induction through a mechanism independent of NF-κB alone. LMP1 and CD40 share a common TRAF binding motif, PXQXT. In this study, the PXQXT motifs in both LMP1 and CD40 were altered and mutant proteins were analyzed for induction of EGFR expression. Replacement of the T residue with A in CD40 completely blocked induction of the EGFR, while the same mutation in LMP1 did not affect EGFR induction. Replacement of both P and Q residues with A’s in LMP1 reduced EGFR induction by >75%, while deletion of PXQXT blocked EGFR induction. These results genetically link EGFR induction by LMP1 to the TRAF signaling pathway. Overexpression of TRAF2 potently activates NF-κB, although TRAF2 did not induce expression of the EGFR either alone or in combination with TRAF1 and TRAF3. In vivo analyses of the interaction of the TRAFs with LMP1 variants mutated in the PXQXT domain indicate that high-level induction of EGFR expression requires interaction with TRAF1, -2, and -3. However, exogenous expression of TRAF3 decreased EGFR induction mediated by either LMP1 or CD40. These data suggest that TRAF-mediated activation of EGFR expression requires assembly of a complex containing the appropriate stoichiometry of TRAF proteins clustered at the cell membrane with LMP1.
Does the stellar distribution flare? A comparison of stellar scale heights with LAB HI data
Creators: name: Kalberla, P. M. W.
name: Kerp, J.
name: Dedes, L.
name: Haud, U.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The question, whether the stellar populations in the Milky Way take part in flaring of the scale heights as observed for the HI gas is a matter of debate. Standard mass models for the Milky Way assume a constant scale height for each of the different stellar distributions. However, there is mounting evidence that at least some of the stellar distributions reach at large galactocentric distances high altitudes that are incompatible with a constant scale height. We discuss recent observational evidence for stellar flaring and compare it with HI data from the Leiden/Argentine/Bonn (LAB) survey. Within the systemic and statistical uncertainties we find a good agreement between both.
description: 20 pages, 3 figures, accepted for publication in The Astrophysical Journal
Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac
Creators: name: Zohn, Irene E.
name: Symons, Marc
name: Westwick, John K.
name: Chrzanowska-Wodnicka, Magdalena
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The Mas oncogene encodes a novel G-protein-coupled receptor that was identified originally as a transforming protein when overexpressed in NIH 3T3 cells. The mechanism and signaling pathways that mediate Mas transformation have not been determined. We observed that the foci of transformed NIH 3T3 cells caused by Mas were similar to those caused by activated Rho and Rac proteins. Therefore, we determined if Mas signaling and transformation are mediated through activation of a specific Rho family protein. First, we observed that, like activated Rac1, Mas cooperated with activated Raf and caused synergistic transformation of NIH 3T3 cells. Second, both Mas- and Rac1-transformed NIH 3T3 cells retained actin stress fibers and showed enhanced membrane ruffling. Third, like Rac, Mas induced lamellipodium formation in porcine aortic endothelial cells. Fourth, Mas and Rac1 strongly activated the JNK and p38, but not ERK, mitogen-activated protein kinases. Fifth, Mas and Rac1 stimulated transcription from common DNA promoter elements: NF-κB, serum response factor (SRF), Jun/ATF-2, and the cyclin D1 promoter. Finally, Mas transformation and some of Mas signaling (SRF and cyclin D1 but not NF-κB activation) were blocked by dominant negative Rac1. Taken together, these observations suggest that Mas transformation is mediated in part by activation of Rac-dependent signaling pathways. Thus, Rho family proteins are common mediators of transformation by a diverse variety of oncogene proteins that include Ras, Dbl family, and G-protein-coupled oncogene proteins.
title: Brief von Gerhard Kreutzer an Josef Steindl
Creators: name: Kreutzer, Gerhard
Year: 2017

description: Betrifft Symposionsband "Vertriebene Vernunft II. Emigration und Exil österreichischer Wissenschaft", hrsg. von Friedrich Stadler.
description: Typoskript mit Unterschrift, 1 Blatt
Mutations of the Drosophila dDP, dE2F, and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G1-S Transition
Creators: name: Duronio, Robert
name: Bonnette, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Activation of heterodimeric E2F-DP transcription factors can drive the G1-S transition. Mutation of the Drosophila melanogaster dE2F gene eliminates transcriptional activation of several replication factors at the G1-S transition and compromises DNA replication. Here we describe a mutation in the Drosophila dDP gene. As expected for a defect in the dE2F partner, this mutation blocks G1-S transcription of DmRNR2 and cyclin E as previously described for mutations of dE2F. Mutation of dDP also causes an incomplete block of DNA replication. When S phase is compromised by reducing the activity of dE2F-dDP by either a dE2F or dDP mutation, the first phenotype detected is a reduction in the intensity of BrdU incorporation and a prolongation of the labeling. Notably, in many cells, there was no detected delay in entry into this compromised S phase. In contrast, when cyclin E function was reduced by a hypomorphic allele combination, BrdU incorporation was robust but the timing of S-phase entry was delayed. We suggest that dE2F-dDP contributes to the expression of two classes of gene products: replication factors, whose abundance has a graded effect on replication, and cyclin E, which triggers an all-or-nothing transition from G1 to S phase.
Multiple Phase Transitions Shape Biodiversity of a Migrating Population
Creators: name: Barkan, Casey
name: Wang, Shenshen
Publisher: name: arXiv
Year: 2022
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: In a wide variety of natural systems, closely-related microbial strains coexist stably, resulting in high levels of fine-scale biodiversity. However, the mechanisms that stabilize this coexistence are not fully understood. Spatial heterogeneity is one common stabilizing mechanism, but the rate at which organisms disperse throughout the heterogeneous environment may strongly impact the stabilizing effect that heterogeneity can provide. An intriguing example is the gut microbiome, where active mechanisms exist to control the movement of microbes and potentially maintain diversity. We investigate how biodiversity is affected by migration rate using a simple evolutionary model with heterogeneous selection pressure. We find that the biodiversity-migration rate relationship is shaped by multiple phase transitions, including a reentrant phase transition to coexistence. At each transition, an ecotype goes extinct and dynamics exhibit critical slowing down (CSD). CSD is encoded in the statistics of fluctuations due to demographic noise -- this may provide an experimental means for detecting and altering impending extinction.
description: 8 pages, 3 figures
An algebraic property of Reidemeister torsion
Creators: name: Kitano, Teruaki
name: Nozaki, Yuta
Publisher: name: arXiv
Year: 2022
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57K31, 57Q10 (Primary) 11R04, 13P15, 57M05 (Secondary)

description: For a 3-manifold $M$ and an acyclic $\mathit{SL}(2,\mathbb{C})$-representation $ρ$ of its fundamental group, the $\mathit{SL}(2,\mathbb{C})$-Reidemeister torsion $τ_ρ(M) \in \mathbb{C}^\times$ is defined. If there are only finitely many conjugacy classes of irreducible representations, then the Reidemeister torsions are known to be algebraic numbers. Furthermore, we prove that the Reidemeister torsions are not only algebraic numbers but also algebraic integers for most Seifert fibered spaces and infinitely many hyperbolic 3-manifolds. Also, for a knot exterior $E(K)$, we discuss the behavior of $τ_ρ(E(K))$ when the restriction of $ρ$ to the boundary torus is fixed.
description: 22 pages, 4 figures
Non-Hermitian ${\cal PT}$-Symmetric Dirac-Pauli Hamiltonians with Real Energy Eigenvalues in the Magnetic Field
Creators: name: Rodionov, V. N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The modified Dirac-Pauli equations, which is entered by means of ${γ_5}$-mass extension of Hamiltonian operators, are considered. We also take into account the interaction of fermions with the intensive homogenous magnetic field focusing attention on (g-2) gyromagnetic factor of particles with spin $1/2$. Without the use of perturbation theory in the external field the exact energy spectra are deduced with regard to spin effects of fermions. We discuss the possible proposals of experimental measuring of properties of new particles which arising in this model.
description: 19 pages, 5 figures, PHHQP2014. arXiv admin note: substantial text overlap with arXiv:1406.0383, arXiv:1404.0503
No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma
Creators: name: Qumsiyeh, Mazin B.
name: Liao, Mai-Jing
name: Van Dyke, Terry
name: Nichols, Warren
name: Zhang, Xiao-Xiang
name: Hill, Rosina
name: Gao, Jingjin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The p53 tumor suppressor is activated in response to a variety of cellular stress signals, although specific in vivo signals that trigger tumor suppression are unknown. In mouse thymocytes, where p53 inactivation leads to tumorigenesis, several observations suggest that V(D)J recombination of T-cell receptor (TCR) loci could provide a DNA damage signal triggering p53-dependent apoptosis and tumor suppression. Inactivation of p53 would allow V(D)J driven mutation of additional cancer genes, facilitating tumorigenesis. Here, we show that mice with a p53 deficiency in thymocytes and unable to carry out V(D)J recombination are not impaired in the development of thymoma. Recombination-activating gene (RAG) deficiencies were introduced into both p53−/−mice and TgTΔN transgenic mice, a strain in which 100% of the mice develop thymoma due to thymocyte-specific inactivation of p53 by a simian virus 40 T-antigen variant. V(D)J recombination was dispensable for tumorigenesis since thymomas developed with or without theRAG-1orRAG-2gene, although some delay was observed. When V(D)J recombination was suppressed by expression of rearranged TCR transgenes, 100% of the TgTΔN mice developed thymoma, surprisingly with reduced latency. Further introduction of a RAG deficiency into these mice had no impact on the timing or frequency of tumorigenesis. Finally, karyotype and chromosome painting analyses showed no evidence for TCR gene translocations in p53-deficient thymomas, although abundant aneuploidy involving frequent duplication of certain chromosomes was present. Thus, contrary to the current hypothesis, these studies indicate that signals other than V(D)J recombination promote p53 tumor suppression in thymocytes and that the mechanism of tumorigenesis is distinct from TCR translocation oncogene activation.
title: Brief von Josef Steindl an Keith Povey
Creators: name: Steindl, Josef
Year: 2017

description: Kopie eines Briefentwurfs. - Auf der Rückseite Briefentwurf an die Direktion des Hotel Edelweiss in Sils Maria mit Bitte um Zimmerreservierung.
description: Typoskript, 1 Blatt, 2 Seiten
L'infirmier en psychiatrie face au suicide de patients
Creators: name: Arellano, Jérôme
name: Morais, Andreia
Publisher: name: Unknown
Year: 0
Subjects: subject: INFIRMIERE EN PSYCHIATRIE
subject: SUICIDE
subject: PATIENT
subject: PSYCHOLOGIE

description: A travers cette revue de littérature, nous souhaitons explorer les différents types d'impacts que peuvent induire le décès par suicide d'un patient dans un contexte de psychiatrie, au sein d'un membre de l'équipe soignante.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain
Creators: name: Whitehead, Ian P.
name: Tognon, Cristina E.
name: Passmore, Lori A.
name: Der, Channing J.
name: Kay, Robert J.
name: Kirk, Heather E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: As part of a cDNA library screen for clones that induce transformation of NIH 3T3 fibroblasts, we have isolated a cDNA encoding the murine homolog of the guanine nucleotide exchange factor RasGRP. A point mutation predicted to prevent interaction with Ras abolished the ability of murine RasGRP (mRasGRP) to transform fibroblasts and to activate mitogen-activated protein kinases (MAP kinases). MAP kinase activation via mRasGRP was enhanced by coexpression of H-, K-, and N-Ras and was partially suppressed by coexpression of dominant negative forms of H- and K-Ras. The C terminus of mRasGRP contains a pair of EF hands and a C1 domain which is very similar to the phorbol ester- and diacylglycerol-binding C1 domains of protein kinase Cs. The EF hands could be deleted without affecting the ability of mRasGRP to transform NIH 3T3 cells. In contrast, deletion of the C1 domain or an adjacent cluster of basic amino acids eliminated the transforming activity of mRasGRP. Transformation and MAP kinase activation via mRasGRP were restored if the deleted C1 domain was replaced either by a membrane-localizing prenylation signal or by a diacylglycerol- and phorbol ester-binding C1 domain of protein kinase C. The transforming activity of mRasGRP could be regulated by phorbol ester when serum concentrations were low, and this effect of phorbol ester was dependent on the C1 domain of mRasGRP. The C1 domain could also confer phorbol myristate acetate-regulated transforming activity on a prenylation-defective mutant of K-Ras. The C1 domain mediated the translocation of mRasGRP to cell membranes in response to either phorbol ester or serum stimulation. These results suggest that the primary mechanism of activation of mRasGRP in fibroblasts is through its recruitment to diacylglycerol-enriched membranes. mRasGRP is expressed in lymphoid tissues and the brain, as well as in some lymphoid cell lines. In these cells, RasGRP has the potential to serve as a direct link between receptors which stimulate diacylglycerol-generating phospholipase Cs and the activation of Ras.
“Verba manent “, un progetto di Public History [poster]
“Verba manent “, un progetto di Public History [poster]
Creators: name: Nencioni, Chiara
Publisher: name: C. Nencioni, "“Verba manent “, un progetto di Public History", in Book of Abstract AIPH 2022, Quarta Conferenza Nazionale di Public History, Storia bene comune, Università Ca’ Foscari Venezia, M9 – Museo del ’900. Venezia-Mestre, 27-31 maggio 2022.
Year: 2022

description: Storie di donne e uomini impegnati nella realizzazione di un mondo più giusto e solidale, senza limiti né geografici né temporali.
title: Massage, aromathérapie ou réflexologie
title: quelle approche de médecine complémentaire pour le patient en soins palliatifs ?
titleType: Subtitle
Creators: name: Araujo, Vasco Joao
Publisher: name: Unknown
Year: 0
Subjects: subject: MASSAGE
subject: AROMATHERAPIE
subject: REFLEXOLOGIE
subject: SOINS PALLIATIFS
subject: MEDECINE COMPLEMENTAIRE

description: Massages, aromathérapie ou réflexologie : quel(s) soin(s) venant compléter la médecine conventionnelle, l’infirmier peut-il proposer au patient adulte et âgé en soins palliatifs, afin d’améliorer son confort et augmenter sa qualité de vie ? Suite au nombre croissant de la population vieillissante en Suisse et des prévisions de demandes en augmentation en soins palliatifs en Suisse, la médecine conventionnelle sera de plus en plus confrontée à ces capacités limitées d’apporter du confort chez le patient. Les médecines complémentaires pourraient venir se joindre à la médecine conventionnelle dans une prise en soins plus globale du patient, avec des approches conçues et mises en oeuvre par les infirmiers.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2015
Tunable plasmonic devices by integrating graphene with ferroelectric nanocavity
Creators: name: Guo, Junxiong
name: Li, Shangdong
name: Chen, Jianbo
name: Cai, Ji
name: Gou, Xin
name: Wang, Shicai
name: Ye, Jinghua
name: Liu, Yu
name: Lin, Lin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Graphene plasmons are able to become the fundermental of novel conceptual photonic devices, resulting from their unique characteristics containing excitation at room temperature and tunable spectral selectivity in different frequencies. The pursuit of efficiently exciting and manipulating graphene plasmons is necessary and significant for high-performance devices. Here, we investigate graphene plasmon wave propagating in ferroelectric nanocavity array. We experimentally show that the the periodic ferroelectric polarizations could be used for doping graphene into desired spatial carrier density patterns. Based on a theoretical model that considers periodic ununiform conductivity across graphene sheet, the simulation results show surface plasmon polaritons (SPP) in graphene can be excited by an incident light in a similar way to the excitation of photonic crystal resonant modes. The graphene SPP resonance can be tuned from ~720 to ~1 000 cm-1 by rescaling the ferroelectric nanocavity array, and from ~540 to ~780 cm-1 by dynamically changing the applied gate voltage. Our strategy of graphene carrier engineering to excite SPP offers a promissing way for large-scale, non-destructive fabrication of novel graphene photonic devices.
description: 16 pages, 7 figures
Characterization of Electron Density of States in Laser-superposed Channeling Regime
Creators: name: Berec, Vesna
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present low-dimensional functionalization and characterization of electron density of states (DOS) using highly correlated/precisely guided proton beam trajectories and a silicon nanocrystal as a target, representing at a same time a versatile nanolaser technique capable for coherent control of atomic quantum states and for scanning the interior of an atom with resolution comparable to 10% of the Bohr radius.
description: 27 pages, 10 figures, Laser and Particle Beams, Cambridge Journals, 2014