cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nordic Walking Improves Postural Alignment and Leads to a More Normal Gait Pattern Following 8 Weeks of Training in Older Adults
Creators: name: Dalton, Christopher
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Nordic walking
Gait
Posture
Older Adults

description: Background: Declines in gait velocity, stride length, cadence, and postural stability are common with advancing age and have further been linked to heightened fall risk and functional decline. Physical activity can slow or prevent such gait declines in older adults. In young adults, Nordic walking (NW) training has been shown to increase stride length and gait speed, yet has demonstrated inconsistent findings regarding joint loading, with reports of both increases and decreases in this respect. Further, research of this facet has very minimally been examined as it pertains to older adults. Purpose: The aim of the present study was to determine both the initial effect, and the prolonged effect following an 8-week intervention, of Nordic walking (NW) on older adult gait performance and postural alignment and stability. Methods: Gait and postural alignment and stability during NW and conventional walking were assessed and compared following an 8-week NW program (2x/week) in 12 healthy older adults (age: 68 ± 6.8 years; 8 female, 4 male). Participants performed six 5m walking trials, 3 with poles and 3 without, followed by two 6 Minute Walk Test (6MWT) trials, one with poles (WP) and the other without (NP). Gait characteristics and trunk measures in the sagittal and frontal planes were quantified using a 6 inertial sensor accelerometry system (APDM, Oregon, USA) as well as an eight camera 3-dimensional motion capture system (Vicon, Oxford, UK) with 2 force platforms (Kistler, Winterthur, Switzerland) embedded within. All variables were assessed using two-way repeated measures ANOVAs to compare NW to conventional walking and before and after the intervention. Results: When comparing walking WP to NP at initial pre-testing, significantly longer stride length, slower gait speed, and increased double support time were found to coincide with decreases in power generation and absorption at the hip and knee WP. However, following prolonged practice, a longer stride length, faster gait speed, and increased power generation at pre-swing at the hip and power absorption during loading and terminal swing about the knee were found WP post-intervention. Conclusions: An initial 8-week training period is necessary for novice NW in order to develop technique and to restore gait and postural alignment to more “normal” standards following training. Additionally, since the acquisition of the skill requires proper allocation of attention between two tasks: walking and pole manipulation, NW should be done so in a relatively safe environment, free of distraction and obstacles. Finally, with frail elderly, a longer acquisition period may be necessary since facilitation of movement must first occur.
ПОДДЕЛЬНЫЕ ПЕРВИЧНАЯ И (ИЛИ) ВТОРИЧНАЯ УПАКОВКИ ЛЕКАРСТВЕННОГО ПРЕПАРАТА ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ (ЧАСТЬ 2 СТАТЬИ 327.2 УК РФ): Критерии и уголовно-правовая квалификация
Creators: name: Лариса Анатольевна Можайская
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: поддельная упаковка и маркировка лекарственных препаратов для медицинского применения
система мониторинга
уголовно-правовая квалификация

description: В работе рассматриваются критерии поддельной первичной и (или) вторичной (потребительской) упаковки лекарственного препарата для медицинского применения, участвующей в обороте фальсифицированных, недоброкачественных и контрафактных лекарственных средств для медицинского применения.
Cretaceous-Paleogene Low Temperature History of the Southwestern Province, Svalbard, Revealed by (U-Th)/He Thermochronometry: Implications for High Arctic Tectonism
Creators: name: Barnes, Christopher
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: (U-Th)/He thermochronology
Southwestern Province
West Spitsbergen Fold-and-Thrust Belt
Wandel Hav Mobile Belt

description: The High Arctic has been a complex region of collisional and extensional tectonism through the Mesozoic and Cenozoic. Svalbard, the sub-aerial exposure of the northwestern Barents Shelf, is an excellent natural laboratory investigating for High Arctic tectonism. Using apatite and zircon (U-Th)/He low-temperature thermochronometry combined with geological constraints, we resolve Cretaceous through Paleogene time-temperature histories for four regions of the Southwestern Province. Our results indicate a temperature gradient from south to north of ~185°C to >200°C, respectively, as a consequence of sedimentary burial and elevated geothermal gradient ( 45°C/km) from High Arctic Large Igneous Province activity. Late Cretaceous cooling affected all regions during regional exhumation related to initial rifting in the Eurasian Basin. During Eurekan tectonism: 1) our models indicate a heating event (55-47 Ma) characterized by overthrusting and a lack of erosion of the West Spitsbergen Fold-and-Thrust Belt, with Central Basin sediments derived from northern Greenland, followed by 2) a subsequent cooling event (47-34 Ma) corresponding to a shift in tectonic regime from compression to dextral strike-slip kinematics; exhumation of the WSFTB coincided with strikeslip tectonics.
Functional Characterization of ABCA4 Missense Variants Linked to Stargardt Macular Degeneration
Creators: name: Garces, Fabian
name: Scortecci, Jessica
name: Molday, Robert S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: ABCA4 is an ATP-binding cassette (ABC) transporter expressed in photoreceptors, where it transports its substrate, N-retinylidene-phosphatidylethanolamine (N-Ret-PE), across outer segment membranes to facilitate the clearance of retinal from photoreceptors. Mutations in ABCA4 cause Stargardt macular degeneration (STGD1), an autosomal recessive disorder characterized by a loss of central vision and the accumulation of bisretinoid compounds. The purpose of this study was to determine the molecular properties of ABCA4 variants harboring disease-causing missense mutations in the transmembrane domains. Thirty-eight variants expressed in culture cells were analyzed for expression, ATPase activities, and substrate binding. On the basis of these properties, the variants were divided into three classes: Class 1 (severe variants) exhibited significantly reduced ABCA4 expression and basal ATPase activity that was not stimulated by its substrate N-Ret-PE; Class 2 (moderate variants) showed a partial reduction in expression and basal ATPase activity that was modestly stimulated by N-Ret-PE; and Class 3 (mild variants) displayed expression and functional properties comparable to normal ABCA4. The p.R653C variant displayed normal expression and basal ATPase activity, but lacked substrate binding and ATPase activation, suggesting that arginine 653 contributes to N-Ret-PE binding. Our classification provides a basis for better understanding genotype–phenotype correlations and evaluating therapeutic treatments for STGD1.
Effects of Remission and Genetic Variation on Brain Structure in Treatment-Resistant Major Depressive Disorder: A Prospective, Longitudinal Imaging Study
Creators: name: Phillips, Jennifer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: subject: Major Depressive Disorder
subject: Magnetic Resonance Imaging
subject: Hippocampus
subject: Brain Volume
subject: Treatment Resistance
subject: Genetics
subject: FOS: Biological sciences
subject: Remission

description: Previous magnetic resonance imaging (MRI) studies have demonstrated brain atrophy in major depressive disorder (MDD) that is progressive with continuing illness and may be reversible with antidepressant treatment. What remains unclear is whether brain structure can be positively affected by pharmacological intervention even if patients fail to remit on the treatment. The primary aim of this thesis was to prospectively track changes in brain structure in patients with treatment-resistant depression while they underwent pharmacotherapy with the goal of attaining remission. There is evidence that gene variants associated with poorer antidepressant response also confer greater risk of volume reduction in the hippocampus. A secondary aim of the thesis was to investigate the effects of monoaminergic-related gene variants on hippocampal volume in patients and controls at baseline imaging. Outpatients with treatment-resistant MDD underwent structural MRI scans at baseline and after either 6-months of sustained remission or 12-months of failure to remit. Matched controls were scanned once to provide comparison data for patients’ baseline scans. Participants also provided blood samples for genetic analyses. Imaging outcome measures included longitudinal changes in whole-brain volume, and gray matter volume and mean cortical thickness within specific cortico-limbic regions of interest (ROIs). Over follow-up, remitted patients had an increase in whole-brain volume, while nonremitted patients lost brain volume despite receiving more treatment strategies. Remitters and nonremitters also showed subtle changes in volume and thickness over time in several ROIs in opposing directions, with increasing hippocampal volume and cortical thickness in the rostral middle frontal gyrus and orbitofrontal cortex in remitters, and decreasing volume or thickness in these regions in nonremitters. Genetic imaging analyses revealed that polymorphisms in certain norepinephrine- and serotonin-related genes have similar effects on hippocampal volume in patients and controls, while the serotonin transporter polymorphism differentially affects hippocampal volume in the presence of depression. Given the observations of volume increase in remitted patients and continuing atrophy in nonremitters, pharmacotherapy in the absence of sustained remission is likely insufficient to elicit structural recovery in depression. This finding is important since the restoration of brain structure in patients with treatment-resistant depression may have positive implications for their future prognosis.
College students' performance appraisal based on professional competency: an example of human resource management
Creators: name: Zhang, Wei
name: Zhong, Weidong
Publisher: name: Swinburne
Year: 2024

description: Because of the disjoint of appraising pattern from educational circle and employers in China, by 360 Degree Feedback, we apply the competency theory to professional performance appraisal of college students in order to help them improve their professional competency and realize the transition from colleges to jobs orderly.
Micronutrient Intake During Pregnancy: Effects of Excessive Folic Acid on Placental Health and Function
Creators: name: Ahmed, Tasfia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: placenta
micronutrients
folic acid
prenatal supplements
pregnancy
cell culture

description: Background: In addition to a diet including fortified dietary staples, the use of prenatal multivitamin supplements among women has been shown, in some cases, to lead to excessive micronutrient intake levels for nutrients such as folic acid (FA). It was therefore hypothesized that prenatal vitamin supplementation, in addition to a standard Canadian diet, would place pregnant Canadians at risk for excessive FA intake. With little available research on the potential negative impact of excess FA intake in pregnancy, it was further proposed that high concentrations of FA may adversely affect placental health and function. Thus, the aim of the current study was three-fold: 1) To determine micronutrient intake in a large Canadian cohort of pregnant women; 2) To determine the extent to which FA intake in this cohort may exceed the tolerable upper intake level (UL) after prenatal supplementation; and 3) To determine the effects of excessive FA exposure on placental health and function in vitro. Methodology: Second trimester 3-day food records of pregnant women (N=216) were analyzed for micronutrient intake using ESHA Food ProcessorTM. Nutrient intake values were compared to established Dietary Reference Intake (DRI) values. In a series of experiments, the effects of exogenous folic acid (2-4000 ng/ml) on placental health and function were examined in two placental cell lines [HTR-8/SVneo (N=3) and BeWo (N=3)], and a human placenta explant model (N=6). Following a 48-hour incubation period, the effects of excessive folic acid exposure on placenta cell proliferation, viability, and apoptosis were determined, along with evaluation of placenta cell function via cell invasion and B-hCG hormone release assays. Results: Through dietary sources alone, most pregnant women studied were consuming adequate levels of most micronutrients. However the majority of examined women (>50%) demonstrated a risk of dietary inadequacy for vitamin D, vitamin E, folate, and iron. In the examined cohort, 83% of study participants reported prenatal supplement usage. In vitro exposure of human placenta cells and explants to excessive FA concentrations resulted in no significant differences in cellular proliferation, apoptosis, invasion, or B-hCG hormone production. However, decreased cell viability was observed in BeWo cells at increased FA concentrations (200-2000 ng/mL). Conclusion: Food sources alone do not appear to provide women in Canada with adequate intake of all micronutrients recommended for a healthy pregnancy. Though a prenatal supplement containing FA may be necessary for most women, current FA levels in many prenatal supplements may lead to excessive FA intake above the established UL. Yet, as measured in this study, high FA concentrations do not seem to adversely affect most primary indicators of placental cell health or function.
Aptamers as Enhancers of Oncolytic Virus Therapy
Creators: name: Muharemagic, Darija
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: aptamers
oncolytic viruses
neutralizing antibodies (nAbs)
CD83
CT26 cells
vesicular stomatitis virus (VSV)

description: Oncolytic viruses promise to significantly improve current cancer treatments through their tumour-selective replication and multimodal attack against cancer cells. However, one of the biggest setbacks for oncolytic virus therapies is the intravenous delivery of the virus, as it can be cleared by neutralizing antibodies (nAbs) from the bloodstream before it reaches the tumour cells. In our group, we have succeeded in developing aptamers to vesicular stomatitis virus (VSV), as well as to rabbit anti-VSV polyclonal neutralizing antibodies (nAbs). We tested these aptamers’ biological activity with a cell-based plaque forming assay and found that the aptamers prevented in vitro neutralization of VSV by nAbs and increased the virus infection rate of transformed cells up to 77%. In line with this approach, we enhanced the delivery of oncolytic viruses by selecting aptamers to the CT26 colon carcinoma cell line. The binding of aptamer pools has been tested on flow cytometry and the best pools were subjected to high throughput sequencing. Selected aptamers were linked to anti-VSV aptamers and applied for target delivery of the virus to cancer cells. Development of this aptamer-based technology aims to improve viral anti-cancer therapies, with a potential to be applied as treatment for patients affected with cancer. Finally, in collaboration with a group from Erlangen University, we performed an aptamer selection using capillary electrophoresis and cell-SELEX. The target, the extracellular domain of human CD83, is a maturation marker for dendritic cells and is involved in the regulation of the immune system. Selected aptamer sequences bound selectively to mature dendritic cells, in comparison to immature dendritic cells, and thus hold promise to be applied for further studies leading to a better understanding of CD83’s mechanism of action.
Robust Chroma Keying System Based on Human Visual Perception and Statistical Color Models
Creators: name: Wang, Wenyi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Chroma Keying

description: In this thesis, we propose a chroma keying system that automatically estimates the alpha map and the reliable intrinsic color of foreground objects in front of solid background. Our system is designed to be capable of distinguishing the transparent foreground from the re flective foreground and shaded background, thereby making the artifacts of the composited image less conspicuous. Speci cally, we assume that the transparent region tends to be with higher saturation and lightness compared with region re ecting background light. With this assumption, a threshold function (TF) on a saturation-lightness plane is de ned according to human visual experiments. The pixels with color mixed with the background light (conventional unknown pixels) are now further categorized into re ective pixels and transparent pixels according to TF. In this case, the re ective and the transparent regions are separated to improve the alpha matte quality. Furthermore, a new color representation model is proposed to estimate the intrinsic color of each pixel according to the global color distribution of the image. The underlying assumption of our proposed model is that all colors in a natural image can be approximated by a limited number of chrominance values (dominant colors). Speci cally, the color statistics are counted by 2D histogram analysis. Then, we approximate the color distribution by the sum of a set of Gaussian mixture functions (GMF), whose centroids are the dominant colors (Dc) of the image. By choosing colors around each Dc, the possible intrinsic colors for each pixel can be comprehensively and e fficiently selected. Considering the fast development of IP-based video broadcasting, we present a data hiding scheme that can protect the chroma keying results when the image/video data is recorded in the JPEG/H.264 format. According to our simulation, the proposed chroma keying system generates high quality composited images that are little a ected by re ecting, background shading, and intrinsic color missing.
Detection of Foodborne Pathogens Using Microfluidic Channels
Creators: name: Hao, Xingkai
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: foodborne pathogen
rapid detection
Escherichia coli O157:H7
microfluidics
dendrimers
aptamers

description: Rapid detection of foodborne pathogen is one of the most urgent problems in the world, because foodborne pathogen could cause serious illness, such as nausea, vomiting and diarrhea. We have developed a sensitive microfluidic system based on dendrimers and aptamers for rapid detection of Escherichia coli O157:H7 at very low cells concentration. Dendrimers, with high level of functional groups and homogeneous spherical shape, are prefect nanoscale polymers used as a template material by increasing sensitivity and specificity of analytes detection in microfluidics. In this work, we develop a sensitive microfluidic system based on dendrimers and aptamers for detecting Escherichia coli O157:H7 at very low cell concentrations. Carboxyl functionalized G7-polyamidoamine (PAMAM-COOH) dendrimers are immobilized on (3-aminopropyl)-trimethoxysilane (APTMS) pretreated microfluidic channels. The aptamers are subsequently conjugated on the immobilized dendrimes through chemicals. The sensitivity and specificity are validated by injecting fluorescein isothiocyanate (FITC) labelled Escherichia coli O157:H7 at various cells concentration into the resulting microchannels, indicating that the detectable cells concentration can be reached as low as 100 (cells/ml) and the detection time is 10 hours. To further exploit and improve the work efficiency our microfluidic device, the microfluidic channel is designed into a staggered herringbone microchannel (SHM) to create the chaotic dynamics inside the microfluidic device, and the SHM is then simulated by a COMSOL software showing that the staggered herringbone structures can improve chaotic dynamics of designed microchannel and will enhance the probability of particles to attach on the surface of microdevice. All the results show that our approach has the potential to develop the field of rapid and accurate detection on foodborne pathogens.
CoDe: Blockwise Control for Denoising Diffusion Models
Creators: name: Singh, Anuj
name: Mukherjee, Sayak
name: Beirami, Ahmad
name: Jamali-Rad, Hadi
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Aligning diffusion models to downstream tasks often requires finetuning new models or gradient-based guidance at inference time to enable sampling from the reward-tilted posterior. In this work, we explore a simple inference-time gradient-free guidance approach, called controlled denoising (CoDe), that circumvents the need for differentiable guidance functions and model finetuning. CoDe is a blockwise sampling method applied during intermediate denoising steps, allowing for alignment with downstream rewards. Our experiments demonstrate that, despite its simplicity, CoDe offers a favorable trade-off between reward alignment, prompt instruction following, and inference cost, achieving a competitive performance against the state-of-the-art baselines. Our code is available at: https://github.com/anujinho/code.
The Influence of Muscular Fatigue on Human Multi-Joint Movement: Determinants of Sit-to-Stand Capacity with Aging
Creators: name: Bryanton, Megan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Sit-to-Stand
Aging
Fatigue
Knee extensors

description: The sit-to-stand (STS) is a multi-articular movement of daily living that requires significantly higher knee extensor (KE) efforts compared to ankle and hip musculature, which approach near maximal levels in older adults populations. As well, fatigue may develop more readily with repetitive actions. Consequently, it is understandable how KE strength reserves have been previously correlated with both functional independence and STS strategy characteristics in older persons, and why STS capacity is a significant predictor of disability. However, it is still unclear why compensatory movement strategies manifest when rising from a seated position, and how this may be influenced by aging. The purpose of this thesis compilation was to evaluate alterations in muscular contributions at the ankle, knee, and hip, in relation to STS performance strategies in young and older adults either: a) with repetitive multi-joint STS exercise or b) before and after isolated fatigue of KE musculature. Results showed that aging caused a redistribution of joint torques when ascending from a seated position, and was associated with significantly higher quadriceps muscular efforts in older persons in comparison to their younger counterparts. In contrast, young and older adults exhibited similar compensatory movement and loading strategies during repetitive STS exercise, which appeared to be limited by the ability to sustain KE force output. In turn, lower KE strength reserves of older persons were responsible for their disproportionately higher quadriceps efforts and reduced STS capacities. Young and older persons also appeared to employ motor strategies to compensate for reduced KE force output via increased contribution of the biarticular rectus femoris within the quadriceps KE synergy, as well as through increases in the initially less active ankle plantar flexor and hip extensor musculature. Older adults may benefit from strengthening of thigh extensor musculature to maintain or improve their strength reserves to promote independent living.
Distributed Crawling of Rich Internet Applications
Creators: name: Mir Taheri, Seyed Mohammad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Distributed Systems
Web Crawlers
Rich Internet Applications

description: Web crawlers visit internet applications, collect data, and learn about new web pages from visited pages. Web crawlers have a long and interesting history. Quick expansion of the web, and the complexity added to web applications have made the process of crawling a very challenging one. Different solutions have been proposed to reduce the time and cost of crawling. New generation of web applications, known as Rich Internet Applications (RIAs), pose major challenges to the web crawlers. RIAs shift a portion of the computation to the client side. Shifting a portion of the application to the client browser influences the web crawler in two ways: First, the one-to-one correlation between the URL and the state of the application, that exists in traditional web applications, is broken. Second, reaching a state of the application is no longer a simple operation of navigating to the target URL, but often means navigating to a seed URL and executing a chain of events from it. Due to these challenges, crawling a RIA can take a prohibitively long time. This thesis studies applying distributed computing and parallel processing principles to the field of RIA crawling to reduce the time. We propose different algorithms to concurrently crawl a RIA over several nodes. The proposed algorithms are used as a building block to construct a distributed crawler of RIAs. The different algorithms proposed represent different trade-offs between communication and computation. This thesis explores the effect of making different trade-offs and their effect on the time it takes to crawl RIAs. We study the cost of running a distributed RIA crawl with client-server architecture and compare it with a peer-to-peer architecture. We further study distribution of different crawling strategies, namely: Breath-First search, Depth-First search, Greedy algorithm, and Probabilistic algorithm. To measure the effect of different design decisions in practice, a prototype of each algorithm is implemented. The implemented prototypes are used to obtain empirical performance measurements and to refine the algorithms. The ultimate refined algorithm is used for experimentation with a wide range of applications under different circumstances. This thesis finally includes two theoretical studies of load balancing algorithms and distributed component-based crawling and sets the stage for future studies.
ЗАВЕДОМО ЛОЖНОЕ СООБЩЕНИЕ ОБ АКТЕ ТЕРРОРИЗМА В СИСТЕМЕ НОРМ ОСОБЕННОЙ ЧАСТИ УГОЛОВНОГО КОДЕКСА РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Оксана Руслановна Догузова
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: преступление
уголовная ответственность
заведомо ложное сообщение
террористический акт
объект преступления
норма Особенной части
общественная безопасность
общественный порядок

description: На основе признаков, характеризующих объект преступления, предусмотренного ст. 207 УК РФ, в статье рассматривается законодательное закрепление заведомо ложного сообщения об акте терроризма в системе норм Особенной части УК РФ. Исследуется законодательная точность используемых признаков в юридической конструкции данной нормы. Особое внимание уделено критериям, характеризующим направленность заведомо ложного сообщения об акте терроризма.
Using Detrital-Zircon Geochronology and (U-Th)/He Thermochronology to Re-evaluate the Triassic-Jurassic Tectonic Setting of Northern Laurentia, Canadian Arctic
Creators: name: Midwinter, Derrick
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Sverdrup Basin
Detrital-Zircon Geochronology
Thermochronology
Arctic Geology

description: New geochronological and field data were examined from Triassic-Jurassic strata in the Sverdrup Basin, Arctic Canada. Detailed analysis of detrital-zircon data identified a pronounced near-syndepositional age-fraction in Triassic strata, which significantly is absent in Jurassic strata of the Sverdrup Basin suggesting a protracted history of magmatism and sediment dispersal from areas north of the basin during the Triassic. However, as a result of rifting, during the Early Jurassic, the northern source region became disconnected from the Sverdrup Basin, and opened the precursor basin (Amerasia Basin) to the Arctic Ocean. Jurassic rifting of the Amerasia Basin would have had associated rift-flank uplift. Time-temperature models produced from zircon (U-Th)/He thermochronological data elucidate the unknown thermal history between the regional Devonian-Cretaceous unconformity in the southwestern Canadian Arctic suggesting ~4 km of addition deposition on Banks Island and ≤1 km of deposition towards the craton interior.
Research training for postgraduate design research: a review and curriculum design proposal
Creators: name: Melles, Gavin
Publisher: name: Swinburne
Year: 2024

description: Design students often come to postgraduate degrees with professional expertise but limited exposure to research and academic literacies. While a range of strategies exist for ensuring such exposure, the design and provision of assessed coursework training for postgraduate design students is a common curriculum strategy. Little is known about the current characteristics of research training in design research and in particular its articulation into the doctoral curriculum and the dissertation and thesis project. This paper examines the articulation of research training in ten institutions in Australia, Italy, the US and UK offering doctorates in design with coursework. Findings from this review were used in the curriculum design of one semester Advanced Design Research Methods (HDR904) at Swinburne University of Technology, where the author teaches. This proposes a hybrid format that may be a useful model for other institutions.
Early Life Predictors of Adolescent Suicidality
Creators: name: Dykxhoorn, Jennifer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Suicidal thoughts
Adolescent
Suicidal ideation
Psychiatric epidemiology
Longitudinal

description: Background: Suicidal thoughts affect 12% of Canadian adolescents. Previous research has linked many factors to suicidality but has not considered how these factors may act together or their effect on non-mental health outcomes. Methods: I used the National Longitudinal Survey of Children and Youth to construct predictive models for suicidal thinking. Recursive partitioning models were constructed and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for suicidal thoughts and secondary outcomes was calculated. I tested the models in the Avon Longitudinal Survey of Parents and Children. Results: Predictive model sensitivity was 24.2%, specificity was 89.8%, PPV was 24.7%, and NPV was 89.5% and had similar accuracy in the second dataset. The models were better at predicting other adverse outcomes compared to suicidal ideas. Conclusion: Exposure to multiple risk factors is predictive of several poor outcomes in adolescence including suicidal thoughts.
0 ПОРЯДКЕ ИСЧИСЛЕНИЯ СРОКОВ ОСВОБОЖДЕНИЯ ОСУЖДЕННЫХ, В ОТНОШЕНИИ КОТОРЫХ ПРИГОВОРЫ СУДОВ ПРИВЕДЕНЫ В СООТВЕТСТВИЕ С ВНОВЬ ИЗДАННЫМ ЗАКОНОМ, СМЯГЧАЮЩИМ НАКАЗАНИЕ ИЛИ ОСВОБОЖДАЮЩИМ ОТ НЕГО
Creators: name: Юрий Николаевич Строгович
name: Рустам Мухамедович Жиляев
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: вновь изданный закон
уголовно-исполнительное законодательство
наказание
порядок исчисления сроков
осужденные
досрочное освобождение

description: В статье рассматриваются вопросы исчисления сроков освобождения осужденных, в отношении которых приговоры судов приведены в соответствие с вновь изданным законом, смягчающим наказание или освобождающим от него на основании статьи 10 Уголовного кодекса Российской Федерации. Обосновывается необходимость единообразного применения части пятой статьи 173 Уголовноисполнительного кодекса Российской Федерации в отношении лиц, отбывающих наказание в виде лишения свободы в исправительных учреждениях и подлежащих освобождению от отбывания наказания по иным основаниям, предусмотренным статьей 172 данного Кодекса.
The ‘My Lai Massacre’ Narrative in American History and Memory: A Story of American Conservatism
Creators: name: Stewart, Eric
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: America
Vietnam War
Son My
My Lai massacre
Conservatism
Memory

description: This thesis uses the referent “My Lai Massacre” to refer to the mythic memory of what happened in Son My on 16 March, 1968. It argues that it is a fitting name for the way it captures the ethnocentrism of the memory in the name by perpetuating an American misnomer rooted in ignorance. It also singularizes the scope of horrors of the day, and fails to differentiate ‘the massacre’ from the domestic turmoil with which it was conflated. The My Lai Massacre narrative as it currently exists in American history and memory is ‘exceptionalist’ in that it incorporates and excludes story elements in such a way that casts it as a highly exceptional occurrence. The main argument of this thesis is that American history and memory of the ‘My Lai Massacre’ have, to a large degree, been defined and shaped by conservative influences. In the time since the news of the atrocities became public this has manifested itself in a number of way and is not confined to conservative histories of the war. Despite the hold liberal orthodox scholarship has on the history of the war, there remains within it, this thesis argues, a conservative trend regarding the massacres in Son My. Reactions, explanations, and rationalizations that appeared in early conservative responses to news of the massacres have survived into a wider ideological spectrum of Vietnam scholarship and memory than that from which it came. Although it seems at first consideration an unlikely event from which a usable past might be constructed, the My Lai Massacre does get used in a didactic manner. This thesis examines some of the most prevalent ways the memory of My Lai functions as a usable past. The My Lai Massacre has been incorporated into a number of ‘lessons of the past’ that tend to be derived from conservative narratives of the war.
ПАНДЕМИЯ КАК ФАКТОР, СПОСОБСТВУЮЩИЙ СОВЕРШЕНИЮ ПРЕСТУПЁЕНИЙ В IT-СФЕРЕ
Creators: name: Дмитрий Николаевич Зорин
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: IT-сфера; преступления
связанные с информационной безопасностью; уголовно-правовая охрана; профилактика

description: В статье рассматриваются вопросы, связанные с уголовно-правовой охраной IT-сферы. Анализируются статьи в Уголовном кодексе Российской Федерации, связанные с обеспечением информационной безопасности. Акцентируется внимание на текущую ситуацию в рассматриваемой области. Предлагаются некоторые пути решения обозначенных проблем.
ОСОБЕННОСТИ ИСПРАВЛЕНИЯ ОСУЖДЕННЫХ В МЕСТАХ ЛИШЕНИЯ СВОБОДЫ
Creators: name: Дарья Николаевна Кротова
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: исправление осужденных
места лишения свободы
психологическое сопровождение
социально-психологический климат
уголовноисполнительная система

description: Статья посвящена таким факторам исправления осужденных в местах лишения свободы, как особенности трудовой занятости осужденных, их психологическое сопровождение, а также влиянию социально-психологического климата в коллективе сотрудников на исправление осужденных.
A 3D Framework for the Musculoskeletal Segmentation of Magnetic Resonance Images
Creators: name: Moghadas Tabatabaei Zavareh, Seyed Mehdi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: MRI
Segmentation
Fuzzy C-Means
Spongy bone
Cortical bone

description: In this thesis a new framework is proposed for obtaining the spongy bone, cortical bone, muscle and adipose tissue from MRI data. The method focuses on the accurate extraction of the edges of the target tissues, which is the main drawback of previous works. In this framework six new methods, as listed in section 1.3, are utilized together for improving the result of the segmentation by detecting the relational position of the tissues, acquiring the best possible contribution from the operator in terms of time and efficiency, forward and backward transfer of the segmented tissues at the seed slice and using the newly proposed Deformable Kernel Fuzzy-C Mean (DKFCM) method for improving the result of segmentation on the edges. This method first limits the searching area for the voxels of the target tissue from the whole data to a small strip around the edges of the target tissue. Then, it applies a very accurate segmentation on the searching area, using a deformable kernel, which is capable of adapting itself with the shape of the edge. Comparing the results of this work with some popular MRI segmentation methods like active contour, watershed, FCM and also some heuristic methods, which are proposed in literature for segmenting the MRI to four tissues, demonstrates the superiority of the proposed method especially on the edges.
0 ПРЕДУПРЕЖДЕНИИ СОВЕРШЕНИЯ НОВЫХ ПРЕСТУПЛЕНИЙ ПРИ ПРИМЕНЕНИИ УСЛОВНО-ДОСРОЧНОГО ОСВОБОЖДЕНИЯ ОТ ОТБЫВАНИЯ НАКАЗАНИЯ: Некоторые аспекты
Creators: name: Алисхан Салангиреевич Ужахов
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: условно-досрочное освобождение
осужденный
предупреждение совершения новых преступлений

description: В статье выявлен ряд проблем уголовного и уголовно-исполнительного законодательства в части учета (не-) возможности совершения нового преступления лицом при применении условно-досрочного освобождения от отбывания наказания. С учетом положений постановления Пленума Верховного Суда РФ «О судебной практике условнодосрочного освобождения от отбывания наказания, замены неотбытой части наказания более мягким видом наказания» от 21 апреля 2009 г. № 8 и мнений проанкетированных автором респондентов делается вывод о том, что ст. 79 УК РФ и ст. 175 УИК РФ требуют совершенствования в контексте предупреждения совершения новых преступлений при применении условно-досрочного освобождения от отбывания наказания.
ЦЕЛИ УГОЛОВНОГО НАКАЗАНИЯ В РЕСПУБЛИКЕ АРМЕНИЯ
Creators: name: Сурен Вазгенович Барсегян
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: Республика Армения
цели наказания
законодательные реформы
ресоциализация

description: Статья посвящена развитию института уголовного наказания в Республике Армения. Анализируется развитие института наказания. Изучаются особенности данного института.
The Contribution of Body Morphology to Individual Variability in the Thermoregulatory Responses to Exercise, and the Effect of Altered Skin Blood Flow on Heat Loss Potential
Creators: name: Cramer, Matthew Nathaniel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: exercise
thermoregulation
core temperature
sweating
body morphology
heat production
evaporative requirements
skin blood flow
heat loss potential

description: Three studies were performed to examine biophysical sources of individual variability in the thermoregulatory responses to exercise, and the influence of skin blood flow on heat loss potential during severe heat stress. Study 1 investigated whether unbiased comparisons of changes in rectal temperature (ΔTre) should be compared at a fixed absolute rate of heat production (Hprod; W) or a fixed Hprod per unit mass (W/kg), and whether local sweat rates (LSR) should be compared at a fixed evaporative requirement for heat balance (Ereq; W) or a fixed Ereq per unit of surface area (W/m2), between independent groups of unequal body mass and body surface area (BSA). Study 2 examined whether individual variation in ΔTre, whole-body sweat loss (WBSL), and steady-state LSR is best explained by biophysical factors related to Hprod, Ereq, and body size, and if factors related to aerobic fitness (VO2max) and body fatness correlate with the residual variance in these responses. Study 3 tested whether alterations in skin blood flow shift the critical vapour pressure (Pcrit) above which core temperature could no longer be regulated in hot/humid conditions, indicating altered heat loss potential from the skin. In study 1, exercise at fixed absolute Hprod and Ereq resulted in greater ΔTre and LSR in smaller individuals (smaller mass and BSA), but exercise at set Hprod in W/kg and Ereq in W/m2 resulted in no differences in ΔTre and LSR, respectively, regardless of body size and %VO2max. In study 2, 50-71% of the individual variation in ΔTre, whole-body sweat loss (WBSL), and steady-state LSR was explained by Hprod (W/kg), absolute Ereq (W) and Ereq (W/m2) respectively, while body fat percentage and %VO2max contributed merely 1-4% to the total variability. In study 3, despite a ~20% lower skin blood flow, Pcrit was unaffected by a large reduction in skin blood flow following iso-smotic dehydration, with no differences in core and skin temperatures and sweating observed. Collectively, these findings suggest that between-group comparisons and modelling of thermoregulatory responses must first consider biophysical factors related to metabolic heat production and body size, rather than factors related to VO2max and body fatness. Furthermore, lower levels of skin blood flow may not impair maximum heat dissipation from the skin to the external environment during severe passive heat stress as previously thought.
ГОСУДАРСТВЕННАЯ ПОЛИТИКА СОЦИАЛИСТИЧЕСКОЙ РЕСПУБЛИКИ ВЬЕТНАМ В СФЕРЕ ОБРАЩЕНИЯ НАРКОТИКОВ И ДЕТОКСИКАЦИИ
Creators: name: Нгуен Тху Тхао
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: политика
наркотик
наркоманы
детоксикация
Вьетнам

description: В данной статье рассматривается государственная политика Вьетнама в сфере обращения наркотиков и детоксикации. Автор разделил на этапы государственную политику Вьетнама в этой сфере и внес свои предложения по преодолению возникающих проблем.
Is There an Association between Herpetic Infections and Giant Cell Arteritis? A Population-Based Study
Creators: name: Lee, Dong-Ho
name: Iovieno, Alfonso
name: Sheldon, Claire A.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Recent data suggests that herpes zoster (HZ) and herpes simplex virus (HSV) may be one of the underlying immunological triggers for giant cell arteritis (GCA). However, there is limited population-based data to support this. Our goal was to determine if herpetic infections increase the likelihood of GCA in the British Columbia (BC) population. The background prevalence of GCA was compared to the prevalence of GCA in subjects with HZ and HSV using diagnostic billing code data from an online BC database (BC Data ScoutTM). BC residents ≥30 years old at the time of diagnosis from January 2000 to January 2019 were included. The relevant International Classification of Disease codes was used to identify patients with GCA, HZ, and HSV. Comparisons were made using two-sample Z tests. There were 4315 GCA diagnoses, from a total population of 3,026,005 subjects. The prevalence of GCA was 143 per 100,000 people. In terms of herpetic infections, 850 GCA cases were identified in 249,900 subjects with HZ versus 310 diagnoses of GCA in 163,170 subjects with HSV. The prevalence of GCA in subjects with HZ (0.340%) was significantly higher than the prevalence of GCA (0.143%) in the general population (p < 0.00001). The prevalence of GCA in HSV subjects (0.190%) was also significantly higher (p < 0.00001) than the population prevalence but lower than (p < 0.00001) the GCA with HZ prevalence. The likelihood of GCA appears to increase with herpetic infections, more significantly with HZ.
Grothendieck Group Decategorifications and Derived Abelian Categories
Creators: name: McBride, Aaron
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: additive categories
abelian categories
exact categories
triangulated categories
Grothendieck groups
category theory
cochain complexes
homotopy category
cohomology
bounded derived category
derived functors

description: The Grothendieck group is an interesting invariant of an exact category. It induces a decategorication from the category of essentially small exact categories (whose morphisms are exact functors) to the category of abelian groups. Similarly, the triangulated Grothendieck group induces a decategorication from the category of essentially small triangulated categories (whose morphisms are triangulated functors) to the category of abelian groups. In the case of an essentially small abelian category, its Grothendieck group and the triangulated Grothendieck group of its bounded derived category are isomorphic as groups via a natural map. Because of this, homological algebra and derived functors become useful in surprising ways. This thesis is an expository work that provides an overview of the theory of Grothendieck groups with respect to these decategorications.
НАУЧНО-ПРАКТИЧЕСКИЕ ПРОБЛЕМЫ РЕАЛИЗАЦИИ ПРАВА ЗАЩИТНИКА СОБИРАТЬ ДОКАЗАТЕЛЬСТВА ПО УГОЛОВНОМУ ДЕЛУ
Creators: name: Жанна Шараповна Гаджимусаева
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: защитник
права защитника
собирание доказательств в уголовном деле
представление доказательств в уголовном деле

description: Научная статья посвящена исследованию проблемы реализации правозащитником права собирать доказательства по уголовному делу.
МЕЖДУНАРОДНО-ПРАВОВЫЕ МЕРЫ ПО ОБЕСПЕЧЕНИЮ МЕЖДУНАРОДНОЙ БЕЗОПАСНОСТИ
Creators: name: Мадина Гасановна Гасанова
Publisher: name: Государственная служба и кадры
Year: 2020
Subjects: безопасность
международная безопасность
международно-правовые акты
системы безопасности

description: В статье исследуются способы международного сотрудничества по обеспечению международной безопасности. Рассматриваются системы безопасности и международно-правовые меры, которые приняты международными организациями для обеспечения безопасности.