cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Excitation of weakly-bound molecules to trilobite-like Rydberg states
Creators: name: Bellos, M. A.
name: Carollo, R.
name: Banerjee, J.
name: Eyler, E. E.
name: Gould, P. L.
name: Stwalley, W. C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We observe "trilobite-like" states of ultracold 85Rb2 molecules, in which a ground-state atom is bound by the electronic wavefunction of its Rydberg-atom partner. We populate these states through the ultraviolet excitation of weakly-bound molecules, and access a regime of trilobite-like states at low principal quantum numbers and with vibrational turning points around 35 Bohr radii. This demonstrates that, unlike previous studies that used free-to-bound transitions, trilobite-like states can also be excited through bound-to-bound transitions. This approach provides high excitation probabilities without requiring high-density samples, and affords the ability to control the excitation radius by selection of the initial-state vibrational level.
description: 4 pages, 3 figures
Mass, Charge and Motion in Covariant Gravity Theories
Creators: name: Gralla, Samuel E
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Previous work established a universal form for the equation of motion of small bodies in theories of a metric and other tensor fields that have second-order field equations following from a covariant Lagrangian in four spacetime dimensions. Differences in the motion of the "same" body in two different theories are entirely accounted for by differences in the body's effective mass and charges in those different theories. Previously the process of computing the mass and charges for a particular body was left implicit, to be determined in each particular theory as the need arises. I now obtain explicit expressions for the mass and charges of a body as surface integrals of the fields it generates, where the integrand is constructed from the symplectic current for the theory. This allows the entire prescription for computing the motion of a small body to be written down in a few lines, in a manner universal across bodies and theories. For simplicity I restrict to scalar and vector fields (in addition to the metric), but there is no obstacle to treating higher-rank tensor fields. I explicitly apply the prescription to work out specific equations for various body types in Einstein gravity, generalized Brans-Dicke theory (in both Jordan and Einstein frames), Einstein-Maxwell theory and the Will-Nordvedt vector-tensor theory. In the scalar-tensor case, this clarifies the origin and meaning of the "sensitivities" defined by Eardley and others, and provides explicit formulae for their evaluation.
description: matches published version
@IT2020: An innovative algorithm for allergen immunotherapy prescription in seasonal allergic rhinitis
Creators: name: Arasi, Stefania
name: Castelli, Sveva
name: Di Fraia, Marco
name: Villalta, Danilo
name: Tripodi, Salvatore
name: Perna, Serena
name: Dramburg, Stephanie
name: Brighetti, Maria Antonia
name: Conte, Mariaelisabetta
name: Martelli, Paola
name: Sfika, Ifigenia
name: Travaglini, Alessandro
name: Verardo, Pier Luigi
name: Villella, Valeria
name: Matricardi, Paolo Maria
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: allergen-specific immunotherapy
subject: clinical decision support system
subject: component resolved diagnostics
subject: mobile health
subject: seasonal allergic rhinitis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Allergen immunotherapy (AIT) is the only disease-modifying treatment in patients with seasonal allergic rhinoconjunctivitis (SAR). Its efficacy depends on the precise identification of the triggering allergen. However, diagnostics based on retrospective clinical history and sensitization to whole extracts (SWE) often leads to equivocal results. Objectives: To assess the usability and impact of a recently established algorithm for a clinical decision support system (@IT2020-CDSS) for SAR and its diagnostic steps [anamnesis, SWE (skin prick test or serum IgE), component resolved diagnosis, CRD, and real-time digital symptom recording, eDiary] on doctor's AIT prescription decisions. Methods: After educational training on the @IT2020-CDSS algorithm, 46 doctors (18 allergy specialists, AS, and 28 general practitioners, GP) expressed their hypothetical AIT prescription for 10 clinical index cases. Decisions were recorded repeatedly based on different steps of the algorithm. The usability and perceived impact of the algorithm were evaluated. Results: The combined use of CRD and an eDiary increased the hypothetical AIT prescriptions, both among AS and GP (p < .01). AIT prescription for pollen and Alternaria allergy based on anamnesis and SWE was heterogeneous but converged towards a consensus by integrating CRD and eDiary information. Doctors considered the algorithm useful and recognized its potential in enhancing traditional diagnostics. Conclusions and clinical implications: The implementation of CRD and eDiary in the @IT2020-CDSS algorithm improved consensus on AIT prescription for SAR among AS and GP. The potential usefulness of a CDSS for aetiological diagnosis of SAR and AIT prescription in real-world clinical practice deserves further investigation.
title: Иерархические уровни обработки информации в системах обнаружения и сопровождения объектов
Creators: name: ., Е.В. Егорова – к.т.н., доцент, кафедра телекоммуникационных систем, МТУ МИРЭА Е-mail: calipso575@gmail.com М.Х. Аксяитов – начальник научно-производственного центра, АО «Концерн «Гранит-Электрон» А.Н. Рыбаков – ведущий специалист, ФГУП ВНИИА им. Н.Л. Духова
Publisher: name: Издательство Радиотехника
Year: 2019

description: Постановка проблемы. Совершенствование интеллектуальных систем обработки и анализа видеоинформации интенсивно применяются в различных областях человеческой деятельности. Наиболее широкое распространение они получили при решении таких задач, как проблематика навигации, космический мониторинг Земли, контроль качества и количества производимой продукции, обеспечение безопасности различных объектов, передача и хранение видеоинформации, в медицинских и специальных приложениях. Одним из направлений при создании систем обработки и анализа видеоинформации является разработка бортовых систем обнаружения и сопровождения объектов, предназначенных для установки на автономных носителях, таких как самолеты, вертолеты, автомобили, надводные суда. Примерами объектов, которые требуется обнаруживать и сопровождать, могут служить летящие самолеты, вертолеты, движущиеся по шоссе автомашины, суда, люди. В качестве фонового изображения могут выступать изображения леса, домов, дорог, облаков и т.п. При этом информация о характеристиках объектов, которые требуется обнаруживать и сопровождать, включает в себя лишь приблизительные размеры объектов. Необходимо выявить структуру системы автоматического сопровождения объектов с определением иерархических уровней обработки информации.
Цель. Провести сравнительный анализ предложенной системы автоматического обнаружения и сопровождения объектов, а также выявить структуру системы автоматического сопровождения объектов, реализующей обработку информации в соответствии с предложенными иерархическими уровнями.
Результаты. Проанализирована структура системы автоматического сопровождения объектов, реализующая обработку информации в соответствии с предложенными иерархическими уровнями. Предложена иерархическая структура, выделяющая уровни обработки информации в системах обнаружения и сопровождения объектов. Выявлено, что в зависимости от задач, решаемых системой обнаружения и сопровождения, а также от используемых для решения подходов некоторые уровни иерархии в конкретной системе могут отсутствовать.
Практическая значимость. Предложенная структура системы автоматического сопровождения объектов, реализующей обработку информации в соответствии с иерархическими уровнями обработки информации в системах обнаружения и сопровождения объектов может быть использована при разработке или совершенствовании существующих методов обработки видеопоследовательностей в образцах самолетной и ракетной техники.
Clinical and neuroimaging findings in MOGAD–MRI and OCT
Creators: name: Bartels, Frederik
name: Lu, Angelo
name: Oertel, Frederike Cosima
name: Finke, Carsten
name: Paul, Friedemann
name: Chien, Claudia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: magnetic resonance imaging
subject: myelin oligodendrocyte glycoprotein associated disorders
subject: optical coherence tomography
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody-associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In-vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord and optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and neuroimaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how image analysis methods have led to recent insights for consideration in future studies.
Determining Triple Gauge Boson Couplings from Higgs Data
Creators: name: Corbett, Tyler
name: Eboli, O. J. P.
name: Gonzalez-Fraile, J.
name: Gonzalez-Garcia, M. C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In the framework of effective Lagrangians with the SU(2)_L x U(1)_Y symmetry linearly realized, modifications of the couplings of the Higgs field to the electroweak gauge bosons are related to anomalous triple gauge couplings (TGCs). Here, we show that the analysis of the latest Higgs boson production data at the LHC and Tevatron give rise to strong bounds on TGCs that are complementary to those from direct TGC analysis. We present the constraints on TGCs obtained by combining all available data on direct TGC studies and on Higgs production analysis. Note added: The analysis has been updated with all the public data available as November 2013. Updates of this analysis are provided at http://hep.if.usp.br/Higgs
description: 5 pages, 1 figure. These results are based on the analysis of the Higgs couplings updated with all available data as November 2013, including the role of two additional operators. These updated results can be found at http://hep.if.usp.br/Higgs
Additional file 2 of Identified barriers and facilitators to stroke risk screening in children with sickle cell anemia: results from the DISPLACE consortium
Creators: name: Phillips, Shannon M.
name: Schlenz, Alyssa M.
name: Mueller, Martina
name: Melvin, Cathy L.
name: Adams, Robert J.
name: Kanter, Julie
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2. DISPLACE Key Informant Interview Guide: Providers
Nonlinear Spectral Singularities for Localized Nonlinearities
Creators: name: Mostafazadeh, Ali
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce a notion of spectral singularity that applies for a general class of nonlinear Schreodinger operators involving a confined nonlinearity. The presence of the nonlinearity does not break the parity-reflection symmetry of spectral singularities but makes them amplitude-dependent. Nonlinear spectral singularities are, therefore, associated with a resonance effect that produces amplified waves with a specific amplitude-wavelength profile. We explore the consequences of this phenomenon for a complex delta-function potential that is subject to a general confined nonlinearity.
description: 5 pages, 1 figure, to appear in Phys. Rev. Lett
Two-dimensional bipolar junction transistors
Creators: name: Gharekhanlou, B.
name: Khorasani, S.
name: Sarvari, R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent development in fabrication technology of planar two-dimensional (2D) materials has brought up possibilities of numerous novel applications. Our recent analysis has revealed that by definition of p-n junctions through appropriate patterned doping of 2D semiconductors, ideal exponential I-V characteristics may be expected. However, the theory of 2D junctions turns out to be very much different to that of the standard bulk junctions. Based on this theory of 2D diodes, here we construct for the first time, a model to describe the 2D Bipolar Junction Transistors (2D-BJTs). We derive the small-signal equivalent model, and estimate the performance of a 2D-BJT device based on Graphone as the example material. A current gain of about 138 and maximum threshold frequency of 77GHz, together with a power-delay product of only 4fJ per 1um lateral width is expected at an operating voltage of 5V. Also, we derive necessary formulae and a new approximate solution for continuity equation in the 2D configuration, which have been verified against numerical solutions.
Additional file 1 of Uncovering the treatable burden of severe aortic stenosis in Australia: current and future projections within an ageing population
Creators: name: Strange, Geoff
name: Scalia, Gregory M.
name: Playford, David
name: Simon, Stewart
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplementary Figure 1. Population Distribution of Australians Aged ≥55 years. Legend: Australia is a federated country, comprising the main populated States (Northern Territory and Capital Territory not shown) of Western Australian (WA), South Australia (SA), Victoria (VIC), Tasmania (TAS), New South Wales (NSW) and Queensland (QLD).
On Spinfoam Models in Large Spin Regime
Creators: name: Han, Muxin
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the semiclassical behavior of Lorentzian Engle-Pereira-Rovelli-Livine (EPRL) spinfoam model, by taking into account the sum over spins in the large spin regime. We also employ the method of stationary phase analysis with parameters and the so called, almost-analytic machinery, in order to find the asymptotic behavior of the contributions from all possible large spin configurations in the spinfoam model. The spins contributing the sum are written as ${J}_f=λ{j}_f$ where $ł$ is a large parameter resulting in an asymptotic expansion via stationary phase approximation. The analysis shows that at least for the simplicial Lorentzian geometries (as spinfoam critical configurations), they contribute the leading order approximation of spinfoam amplitude only when their deficit angles satisfy $γΘ_f\leqλ^{-1/2}$ mod $4π\mathbb{Z}$. Our analysis results in a curvature expansion of the semiclassical low energy effective action from the spinfoam model, where the UV modifications of Einstein gravity appear as subleading high-curvature corrections.
description: 20 pages, no figure, presentation improved, published version
Unidentified
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2019

description: Shirly Temple sings "Come and Get your Happiness", The Fat City High School Fight Song, "Bip Bop" by Paul McCartney and the Wings, "Company Way" from How to Succeed in Business. Woman calls in talks about happiness in jobs. Man talks about paranoia. They discuss Ford's wife's masectomy. Fass complains about taxes. Ends with 20 y-o man dying of leukemia
Additional file 2 of Uncovering the treatable burden of severe aortic stenosis in Australia: current and future projections within an ageing population
Creators: name: Strange, Geoff
name: Scalia, Gregory M.
name: Playford, David
name: Simon, Stewart
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Supplementary Figure 2. Estimated Treatable Burden/Management of Severe AS in Australia (Based on Incident Cases per Annum).
Separating the bulk and surface n- to p-type transition in the topological insulator GeBi(4-x)SbxTe7
Creators: name: Muff, Stefan
name: von Rohr, Fabian
name: Landolt, Gabriel
name: Slomski, Bartosz
name: Schilling, Andreas
name: Cava, Robert J.
name: Osterwalder, Jürg
name: Dil, J. Hugo
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We identify the multi-layered compound GeBi4Te7 to be a topological insulator with a freestanding Dirac point, slightly above the valence band maximum, using angle-resolved photoemission spectroscopy (ARPES) measurements. The spin polarization satisffies the time reversal symmetry of the surface states, visible in spin-resolved ARPES. For increasing Sb content in GeBi(4-x)SbxTe7 we observe a transition from n- to p-type in bulk sensitive Seebeck coefficient measurements at a doping of x = 0.6. In surface sensitive ARPES measurements a rigid band shift is observed with Sb doping, accompanied by a movement of the Dirac point towards the Fermi level. Between x = 0.8 and x = 1 the Fermi level crosses the band gap, changing the surface transport regime. This difference of the n- to p-type transition between the surface region and the bulk is caused by band bending effects which are also responsible for a non-coexistence of insulating phases in the bulk and in the near surface region.
description: 6 pages, 4 figures
In vitro and in vivo anti-epileptic efficacy of eslicarbazepine acetate in a mouse model of KCNQ2-related self-limited epilepsy
Creators: name: Monni, Laura
name: Kraus, Larissa
name: Dipper‐Wawra, Matthias
name: Soares‐Da‐Silva, Patricio
name: Maier, Nikolaus
name: Schmitz, Dietmar
name: Holtkamp, Martin
name: Fidzinski, Pawel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: acute seizures models
subject: encephalopathy
subject: eslicarbazepine acetate
subject: hippocampal oscillations
subject: mouse
subject: seizure-like event
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and purpose: The KCNQ2 gene encodes for the Kv 7.2 subunit of non-inactivating potassium channels. KCNQ2-related diseases range from autosomal dominant neonatal self-limited epilepsy, often caused by KCNQ2 haploinsufficiency, to severe encephalopathies caused by KCNQ2 missense variants. In vivo and in vitro effects of the sodium channel blocker eslicarbazepine acetate (ESL) and eslicarbazepine metabolite (S-Lic) in a mouse model of self-limited neonatal epilepsy as a first attempt to assess the utility of ESL in the KCNQ2 disease spectrum was investigated. Experimental approach: Effects of S-Lic on in vitro physiological and pathological hippocampal neuronal activity in slices from mice carrying a heterozygous deletion of Kcnq2 (Kcnq2+/- ) and Kcnq2+/+ mice were investigated. ESL in vivo efficacy was investigated in the 6-Hz psychomotor seizure model in both Kcnq2+/- and Kcnq2+/+ mice. Key results: S-Lic increased the amplitude and decreased the incidence of physiological sharp wave-ripples in a concentration-dependent manner and slightly decreased gamma oscillations frequency. 4-Aminopyridine-evoked seizure-like events were blocked at high S-Lic concentrations and substantially reduced in incidence at lower concentrations. These results were not different in Kcnq2+/+ and Kcnq2+/- mice, although the EC50 estimation implicated higher efficacy in Kcnq2+/- animals. In vivo, Kcnq2+/- mice had a lower seizure threshold than Kcnq2+/+ mice. In both genotypes, ESL dose-dependently displayed protection against seizures. Conclusions and implications: S-Lic slightly modulates hippocampal oscillations and blocks epileptic activity in vitro and in vivo. Our results suggest that the increased excitability in Kcnq2+/- mice is effectively targeted by S-Lic high concentrations, presumably by blocking diverse sodium channel subtypes.
Purification-based metric to measure the distance between quantum states and processes
Creators: name: Osan, Tristan M.
name: Lamberti, Pedro W.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work we study the properties of an purification-based entropic metric for measuring the distance between both quantum states and quantum processes. This metric is defined as the square root of the entropy of the average of two purifications of mixed quantum states which maximize the overlap between the purified states. We analyze this metric and show that it satisfies many appealing properties, which suggest this metric is an interesting proposal for theoretical and experimental applications of quantum information.
description: 11 pages, 2 figures. arXiv admin note: text overlap with arXiv:quant-ph/0408063, arXiv:1107.1732 by other authors
Dynamical noncommutative quantum mechanics
Creators: name: Alavi, S. A.
name: Abbaspour, S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study some basic and interesting quantum mechanical systems in dynamical noncommutative spaces in which the space- space commutation relations are position dependent. It is observed that the fundamental objects in the dynamical noncommutative space introduced here are stringlike. We show that the Stark effect can be employed to determine whether the noncommutativity of space is dynamical or non-dynamical. It appears that unlike non-dynamical case there is a fundamental energy $\dfrac{τ\hbar^{2}}{m}$ in this dynamical space.}
description: 11 pages, no figures, replaced with the version accepted for publication in "Journal of Physics A: Mathematical and Theoretical"
QCD sum rule study on the $f_0(980)$ structure as a pure $K \bar{K}$ bound state
Creators: name: Lee, Hee-Jung
name: Kochelev, N. I.
name: Oh, Yongseok
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We perform a QCD sum rule analysis for the scalar $f_0(980)$ meson to investigate whether it can be described as a pure bound state of $K$ and $\bar{K}$ mesons. Based on the QCD sum rule with the operators of up to dimension 10 within the operator product expansion, we found that it is hard to treat the $f_0(980)$ as a simple $K\bar{K}$ bound state, which implies that the $f_0(980)$ scalar meson has more complicated structure being mixed states of various configurations.
description: REVTeX, 4 pages, 3 figures, revised version to appear in Phys. Rev. D
Additional file 1 of Psychometric validation of the Hypoparathyroidism Patient Experience Scales (HPES)
Creators: name: Brod, Meryl
name: McLeod, Lori
name: Markova, Denka
name: Gianettoni, Jill
name: Mourya, Sanchita
name: Lin, Zhengning
name: Shu, Aimee
name: Smith, Alden
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1: Figure S1. Missing-Data Simulations: Scatterplot of SDs of Baseline HPES-Symptom and HPES-Impact Total and Domain Scores Group-level Mean of the SD in Simulated (500X) Scores Computed with Different Numbers of Missing Item Responses Among Subjects with Complete Data (N = 223 to 300).
Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease
Creators: name: Kintscher, Ulrich
name: Bakris, George L.
name: Kolkhof, Peter
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: aldosterone
subject: antagonist
subject: cardiovascular disease
subject: diabetic kidney disease
subject: mineralocorticoid receptor
subject: nonsteroidal
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mineralocorticoid receptor antagonists (MRAs) are key agents in guideline-oriented drug therapy for cardiovascular diseases such as chronic heart failure with reduced ejection fraction and resistant hypertension. Currently available steroidal MRAs are efficacious in reducing morbidity and mortality; however, they can be associated with intolerable side effects including hyperkalaemia in everyday clinical practice. Recently, a new class of non-steroidal MRAs (including esaxerenone, AZD9977, apararenone, KBP-5074 and finerenone) have been developed with an improved benefit-risk profile and a novel indication for finerenone for diabetic kidney disease. To better understand the non-steroidal MRAs, this review provides information on the molecular pharmacology as well as relevant current preclinical and clinical data on cardiorenal outcomes. A comparative review of all compounds in the class is discussed with regard to clinical efficacy and safety as well as a perspective outlining their future use in clinical practice. LINKED ARTICLES: This article is part of a themed issue on Emerging Fields for Therapeutic Targeting of the Aldosterone-Mineralocorticoid Receptor Signaling Pathway. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.13/issuetoc
Reducing assembly complexity of microbial genomes with single-molecule sequencing
Creators: name: Koren, Sergey
name: Harhay, Gregory P
name: Smith, Timothy PL
name: Bono, James L
name: Harhay, Dayna M
name: Mcvey, D. Scott
name: Radune, Diana
name: Bergman, Nicholas H
name: Phillippy, Adam M
Publisher: name: arXiv
Year: 2013
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Background: The short reads output by first- and second-generation DNA sequencing instruments cannot completely reconstruct microbial chromosomes. Therefore, most genomes have been left unfinished due to the significant resources required to manually close gaps in draft assemblies. Third-generation, single-molecule sequencing addresses this problem by greatly increasing sequencing read length, which simplifies the assembly problem. Results: To measure the benefit of single-molecule sequencing on microbial genome assembly, we sequenced and assembled the genomes of six bacteria and analyzed the repeat complexity of 2,267 complete bacteria and archaea. Our results indicate that the majority of known bacterial and archaeal genomes can be assembled without gaps, at finished-grade quality, using a single PacBio RS sequencing library. These single-library assemblies are also more accurate than typical short-read assemblies and hybrid assemblies of short and long reads. Conclusions: Automated assembly of long, single-molecule sequencing data reduces the cost of microbial finishing to $1,000 for most genomes, and future advances in this technology are expected to drive the cost lower. This is expected to increase the number of completed genomes, improve the quality of microbial genome databases, and enable high-fidelity, population-scale studies of pan-genomes and chromosomal organization.
description: Published in Genome Biology: http://genomebiology.com/2013/14/9/R101/ Supplementary materials available from: http://www.cbcb.umd.edu/software/PBcR/closure/index.html Reducing assembly complexity of microbial genomes with single-molecule sequencing. Koren S, Harhay GP, Smith TPL, Bono JL, Harhay DM, Mcvey SD, Radune D, Bergman NH, Phillippy AM. Genome Biology 14:R101 2013
title: Aρχιτεκτονική και χρώμα: η περίπτωση του Luis Barragan
Creators: name: Κωμοδρομου Μαρια
Publisher: name: Technical University of Crete
Year: 2016

description: Αντικείμενο της παρούσας ερευνητικής εργασίας είναι η μελέτη του χρώματος
στην αρχιτεκτονική του Luis Barragán μέσα από την παραδοσιακή αρχιτεκτονική του Μεξικού. Αρχικά εξετάζεται η ενεργητική επίδραση του χρώματος σε ολόκληρο τον οργανισμό μας, καθώς διεγείρει όχι μόνο την αίσθηση της όρασης, αλλά και άλλα αισθητικά και ζωτικά όργανα. Δεδομένου ότι, το οπτικό μας σύστημα αντιλαμβάνεται το χρώμα μέσω συγκρίσεων, στην εργασία αναλύονται οι χρωματικές αντιθέσεις, οι οποίες συμβάλλουν καθοριστικά στην υλοποίηση ενός στοχευμένου σχεδιασμού. Ακολούθως γίνεται αναφορά στον τρόπο με τον οποίο το χρώμα κυριάρχησε τόσο στην παραδοσιακή αρχιτεκτονική των λαών της Ευρώπης όσο και στην αρχιτεκτονική του
Μοντερνισμού. Συγκεκριμένα, στην παραδοσιακή αρχιτεκτονική το χρώμα
χρησιμοποιήθηκε με βάση τις κλιματολογικές συνθήκες, το φυσικό περιβάλλον και τις ανάγκες του κάθε λαού. Τέλος, γίνεται μια σύγκριση των χρωματικών αντιθέσεων του Luis Barragán με αυτές των Meerwein, Rodeck και Mahnke.
Στόχος μας είναι να καταδείξουμε πώς το χρώμα επηρεάζει την αρχιτεκτονική
μέσω διερεύνησης των επιπτώσεων στην ανθρώπινη ψυχολογία. Το χρώμα δεν έχει απλά διακοσμητικό ρόλο, αποτελεί στοιχείο που συμμετέχει στη διαδικασία του σχεδιασμού ενός αρχιτεκτονικού έργου, συμβάλλοντας έτσι στην εξέλιξη καθώς και στην τελική εικόνα του έργου.
Modeling vitreous silica bilayers
Creators: name: Wilson, Mark
name: Kumar, Avishek
name: Sherrington, David
name: Thorpe, M. F.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We computer model a free-standing vitreous silica bilayer which has recently been synthesized and characterized experimentally in landmark work. Here we model the bilayer using a computer assembly procedure that starts from a single layer of amorphous graphene, generated using a bond switching algorithm from an initially crystalline graphene structure. Next each bond is decorated with an oxygen atom and the carbon atoms are relabeled as silicon. This monolayer can be now thought of as a two dimensional network of corner sharing triangles. Next each triangle is made into a tetrahedron, by raising the silicon atom above each triangle and adding an additional singly coordinated oxygen atom at the apex. The final step is to mirror reflect this layer to form a second layer and then attach the two layers together to form the bilayer. We show that this vitreous silica bilayer has the additional macroscopic degrees of freedom to easily form a network of identical corner sharing tetrahedra if there is a symmetry plane through the center of the bilayer going through the layer of oxygen ions that join the upper and lower layers. This has the consequence that the upper rings lie exactly above the lower rings, which are tilted in general. The assumption of a network of perfect corner sharing tetrahedra leads to a range of possible densities that we have previously characterized in three dimensional zeolites as a flexibility window. Finally, using a realistic potential, we have relaxed the bilayer to determine the density, and other structural characteristics such as the Si-Si pair distribution functions and the Si-O-Si bond angle distribution, which are compared to the experimental results obtained by direct imaging.
Atomistic Full-Band Simulations of Monolayer MoS2 Transistors
Creators: name: Chang, Jiwon
name: Register, Leonard F.
name: Banerjee, Sanjay K.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the transport properties of deeply scaled monolayer MoS2 n-channel metal-oxide-semiconductor field effect transistors (MOSFETs) using full-band ballistic quantum transport simulations with an atomistic tight-binding Hamiltonian obtained from density functional theory. Our simulations suggest that monolayer MoS2 MOSFETs can provide near-ideal subthreshold slope, and suppression of drain-induced barrier lowering (DIBL) and gate-induced drain leakage (GIDL). However, these full-band simulations also exhibit limited transconductance. These ballistic simulations also exhibit negative differential resistance (NDR) in the output characteristics associated with the narrow width in energy of the lowest conduction band, but this NDR may be substantially reduced or eliminated by scattering in MoS2.
description: Accepted for publication in Applied Physics Letters
Mapeo con niños: sus lugares y sus caminos
Creators: name: Michael K. McCall
Publisher: name: IVIDES.org, Rio de Janeiro.
Year: 2022

description: Palestra ministrada no Workshop Mapeamento Participativo e Cartografia Social 2022, em 14 de dezembro de 2022. Este é um evento organizado pelo Instituto Virtual para o Desenvolvimento Sustentável - IVIDES.org, com parceria do Laboratório de Cartografia - GeoCart-UFRJ.

Vídeo no canal do IVIDES.org no YouTube: https://www.youtube.com/live/30Zi_eTMtyo

Este material está sob a licença Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). Você pode adaptar esta apresentação e disseminá-la, desde que mencione a autoria, mas não pode usar com fins comerciais.
Additional file 2 of Psychometric validation of the Hypoparathyroidism Patient Experience Scales (HPES)
Creators: name: Brod, Meryl
name: McLeod, Lori
name: Markova, Denka
name: Gianettoni, Jill
name: Mourya, Sanchita
name: Lin, Zhengning
name: Shu, Aimee
name: Smith, Alden
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2.
Additional file 3 of Quantifying and communicating the burden of COVID-19
Creators: name: von Cube, Maja
name: Timsit, Jéan-Francois
name: Kammerlander, Andreas
name: Schumacher, Martin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3.
Additional file 1 of The social licence for data-intensive health research: towards co-creation, public value and trust
Creators: name: Muller, Sam H. A.
name: Kalkman, Shona
name: van Thiel, Ghislaine J. M. W.
name: Mostert, Menno
name: van Delden, Johannes J. M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table: Table indicating search strings for databases used (15 February 2021).
Additional file 2 of The social licence for data-intensive health research: towards co-creation, public value and trust
Creators: name: Muller, Sam H. A.
name: Kalkman, Shona
name: van Thiel, Ghislaine J. M. W.
name: Mostert, Menno
name: van Delden, Johannes J. M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Table: Table detailing inclusion and exclusion criteria.
Accelerating clinical research in neuromyelitis optica spectrum disorders
Creators: name: Oertel, Frederike C.
name: Paul, Friedemann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: neuromyelitis optica
subject: diagnostic imaging
subject: biomarkers
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Neuromyelitis optica spectrum disorders are rare relapsing inflammatory central nervous system diseases with a heterogenous immunological and clinical spectrum. International collaborations are required to: (i) reach a better understanding of the disease and its subtypes; (ii) develop laboratory and imaging biomarkers; and (iii) ultimately improve treatments.
title: Περιπλανήσεις στην πόλη. Σημειακές επεμβάσεις στη περιοχή του Κουκακίου
Creators: name: Χριστιδη Νεφελη-Αλεξανδρα
name: Χρυσανθοπουλου Μαρινα
Publisher: name: Technical University of Crete
Year: 2017

description: Η παρούσα εργασία αφορά στο σχεδιασμό δημόσιου χώρου σε ένα ήδη αστικά διαμορφωμένο περιβάλλον, το Κουκάκι. Η περιοχή εντοπίζεται στο κέντρο της Αθήνας και οριοθετείται από τις οδούς Συγγρού, Καλλιρόης, Ροβέρτου Γκάλη και τον περιφερειακό του Φιλοπάππου. Το Κουκάκι αποτελεί μια περιοχή που υπόκεινται σε συνεχείς χωρικούς μετασχηματισμούς, προσπαθώντας να ισορροπήσει ανάμεσα στο σύγχρονο αναπτυξιακό μοντέλο και τα στοιχεία μιας προϋπάρχουσας χωρικής δομής. Σκοπός της εργασίας, είναι η διαχείριση του υπαίθριου χώρου σε δύο επίπεδα. Από τη μία επιδιώκεται η ενδυνάμωση του χαρακτήρα της γειτονιάς μέσα από τη δημιουργία ενός δικτύου δημόσιων χώρων, ενώ παράλληλα, γίνεται προσπάθεια σύνδεσης της αστικής πυκνότητας με το φυσικό τοπίο του λόφου του Φιλοπάππου. Αυτό έχει ως αποτέλεσμα, τη δημιουργία ενός ευρύτερου δικτύου πορειών και επεμβάσεων στη περιοχή, που συμβάλει στην αναβάθμισή της.
Inside the degenerate horizons of regular black holes
Creators: name: Matyjasek, Jerzy
name: Sadurski, Pawel
name: Tryniecki, Dariusz
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The regularized stress-energy tensor of the quantized massive scalar, spinor and vector fields inside the degenerate horizon of the regular charged black hole in the (anti-)de Sitter universe is constructed and examined. It is shown that although the components of the stress-energy tensor are small in the vicinity of the black hole degenerate horizon and near the regular center, they are quite big in the intermediate region. The oscillatory character of the stress-energy tensor can be ascribed to various responses of the higher curvature terms to the changes of the metric inside the (degenerate) event horizon, especially in the region adjacent to the region described by the nearly flat metric potentials. Special emphasis is put on the stress-energy tensor in the geometries being the product of the constant curvature two-dimensional subspaces.
description: Title modified to match published version. References added
Effects of training oncology physicians advising patients on complementary and integrative therapies on patient‐reported outcomes: A multicenter, cluster‐randomized trial
Creators: name: Rogge, Alizé A.
name: Helmer, Stefanie M.
name: King, Ryan
name: Canella, Claudia
name: Icke, Katja
name: Pach, Daniel
name: Witt, Claudia M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: cancer
subject: clinical trials
subject: complementary medicine
subject: integrative oncology
subject: physician-patient communication
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Many patients with cancer do not disclose complementary medicine use but want their physician's advice on this matter. This study evaluated whether using blended learning (e-learning plus a workshop) to train oncology physicians in providing advice on complementary and integrative medicine (CIM) therapies to their patients with cancer, in addition to distributing an information leaflet on reputable CIM websites, had different effects on patient-reported outcomes for the consultation than only distributing the leaflet. Methods: In this multicenter, cluster-randomized trial, patients from private practices/hospital departments, recruited by 48 oncology physicians randomly allocated to an intervention group (CIM consultation plus information leaflet) or a control group (information leaflet), received CIM information. Patient-reported outcomes included satisfaction (Patient Satisfaction With Information on Cancer Treatment), readiness to make a decision (Preparation for Decision Making), and physician-patient communication (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire and Communication 26 [EORTC QLQ-COMU26]) for the consultation. Qualitative interviews were conducted with a physician subsample. Results: A total of 291 patients (128 in the intervention group and 169 in the control group) advised by 41 physicians participated. Patients in the intervention group rated physician-patient communication higher on all EORTC QLQ-COMU26 scales (mean total score, 84.3 [95% CI, 79.5-89.2] vs 73.6 [95% CI, 69.3-78.0]; P = .002), were more satisfied with the advice (mean, 4.2 [95% CI, 4.0-4.4] vs 3.7 [95% CI, 3.5-3.8]; P < .001), and were readier to make a decision (mean, 63.5 [95% CI, 57.4-69.6] vs 53.2 [95% CI, 47.8-58.7]; P = .016) than the control group. Physicians who reported patients in both settings seemed satisfied with the advice given. Conclusions: This study evaluated a novel education intervention for training oncology physicians in providing CIM advice in routine care. Providing structured CIM consultations had positive effects on patient satisfaction, readiness to make decisions, and physician-patient communication.
GLI3 variants causing isolated polysyndactyly are not restricted to the protein's C-terminal third
Creators: name: Sczakiel, Henrike Lisa
name: Hülsemann, Wiebke
name: Holtgrewe, Manuel
name: Abad‐Perez, Angela Teresa
name: Elsner, Jonas
name: Schwartzmann, Sarina
name: Horn, Denise
name: Spielmann, Malte
name: Mundlos, Stefan
name: Mensah, Martin Atta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: GCPS
subject: genotype-phenotype correlations
subject: GLI3
subject: PHS
subject: polydactyly
subject: syndactyly
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Loss of function variants of GLI3 are associated with a variety of forms of polysyndactyly: Pallister-Hall syndrome (PHS), Greig-Cephalopolysyndactyly syndrome (GCPS), and isolated polysyndactyly (IPD). Variants affecting the N-terminal and C-terminal thirds of the GLI3 protein have been associated with GCPS, those within the central third with PHS. Cases of IPD have been attributed to variants affecting the C-terminal third of the GLI3 protein. In this study, we further investigate these genotype-phenotype correlations. Sequencing of GLI3 was performed in patients with clinical findings suggestive of a GLI3-associated syndrome. Additionally, we searched the literature for reported cases of either manifestation with mutations in the GLI3 gene. Here, we report 48 novel cases from 16 families with polysyndactyly in whom we found causative variants in GLI3 and a review on 314 previously reported GLI3 variants. No differences in location of variants causing either GCPS or IPD were found. Review of published data confirmed the association of PHS and variants affecting the GLI3 protein's central third. We conclude that the observed manifestations of GLI3 variants as GCPS or IPD display different phenotypic severities of the same disorder and propose a binary division of GLI3-associated disorders in either PHS or GCPS/polysyndactyly.
Exact RG Flow in an Expanding Universe and Screening of the Cosmological Constant
Creators: name: Kaya, Ali
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We obtain the exact renormalization group (RG) flow equation for a self interacting real scalar field in an expanding cosmological background. The beta functional for the potential in the local potential approximation is determined in terms of the mode functions defining the vacuum of the theory. For a scalar in an inflating universe, which is released in the Bunch-Davies vacuum, the flow equation is analyzed in detail using the optimized cutoff function for the quartically truncated potential. In that case, the constant term in the potential, which can in fact be viewed as the cosmological constant, decreases as the IR cutoff is removed, supporting the existence of a quantum mechanical screening mechanism. On the other hand, the running of the quartic coupling constant at IR is altered by the expansion, which seems to affect the quantum triviality of the theory.
description: 15 pages, 2 figures, revtex4-1, v2: A discussion section and references are added, minor changes, to appear in Phys. Rev. D
title: Σχεδιά (Ζωντας) συλλογικά στην πλατεία Μελχισεδέκ
Creators: name: Ραμμου Ερμιονη
name: Ντουλου Ισιδωρα
name: Μαμουνα Υπατια
Publisher: name: Technical University of Crete
Year: 2017

description: Στην παρούσα Διπλωματική εργασία πραγματοποιήσαμε ένα πείραμα ενεργοποίησης και συλλογικής διαμόρφωσης ενός ελεύθερου δημοσίου χώρου -πλατεία Μελχισεδέκ- στην Παλιά Πόλη των Χανίων, με τη συμμετοχή των κατοίκων της γειτονιάς και της ευρύτερης περιοχής, με σκοπό τη δημιουργία ενός "κοινού τόπου" συνάντησης και αλληλεπίδρασης.
Unidentified
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2019
Subjects: Actors

description: Actors from the play "The Hostage," including Bill Christopher (?), Joe Mahar (?), Ian Thompson (?), England Hawkins (?), Dennis Tate (?), Elliot Kuger (?), and Kylie Rogalo (?) are in the studio discussing their play. They sing "What's The News"