cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells
Creators: name: Yu, Chun-Hong
name: Yang, Shui-Qing
name: Li, Lei
name: Xin, Yu
name: Zhang, Fang
name: Liu, Xiao-Fan
name: Yi, Zong-Chun
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. HQ-regulated DEGs of K562 cells in the Wnt signaling pathway. The Wnt signaling pathway was downloaded from the KEGG database ( https://www.kegg.jp/kegg-bin/show_pathway?map04310 ). In K562 cells, HQ-upregulated DEGs were colored pink and HQ-downregulated DEGs were colored green. Supplementary Figure 2. HQ-regulated DEGs of K562 cells in chronic myeloid leukemia pathway. The chronic myeloid leukemia pathway was downloaded from the KEGG database ( https://www.kegg.jp/kegg-bin/show_pathway?map05220 ). In K562 cells, HQ-upregulated DEGs were colored pink and HQ-downregulated DEGs were colored green. Supplementary Figure 3. HQ-regulated DEGs of K562 cells in acute myeloid leukemia pathway. The acute myeloid leukemia pathway was downloaded from the KEGG database ( https://www.kegg.jp/kegg-bin/show_pathway?map05221 ). In K562 cells, HQ-upregulated DEGs were colored pink and HQ-downregulated DEGs were colored green. Supplementary Figure 4. HQ-regulated DEGs of K562 cells in hematopoietic cell lineage pathway. The hematopoietic cell lineage pathway was downloaded from the KEGG database ( https://www.kegg.jp/kegg-bin/show_pathway?map04640 ). In K562 cells, HQ-upregulated DEGs were colored pink and HQ-downregulated DEGs were colored green. Supplementary Figure 5. HQ-regulated DEGs of K562 cells in human T-cell leukemia virus 1 infection pathway. The human T-cell leukemia virus 1 infection pathway was downloaded from the KEGG database ( https://www.kegg.jp/kegg-bin/show_pathway?map05166 ). In K562 cells, HQ-upregulated DEGs were colored pink and HQ-downregulated DEGs were colored green.
Strategic regional planning for the Lower Mainland of British Columbia, 1969-1981 : a systems interpretation
Creators: name: Pawsey, Stuart
Publisher: name: University of British Columbia
Year: 2010

description: This thesis provides a long term analysis of strategic regional planning for the Lower Mainland of British Columbia, 1969-1981. However, the very nature of such a long term study exposes research problems that are masked by the traditional, short term or 'snap shot' approach. The first chapter reviews the problems of the traditional approach and argues that the lack of a dynamic, systems oriented approach in strategic regional planning stems from a theoretical gap between grand, i.e., general, theories and empirically testable hypotheses. In the theoretical framework, chapter two, Faludi's (1973) classification scheme is selected as the most evolved example of a middle range or contingency theory within the ambit of procedural planning theory. Faludi's three dimensions of planning—the blueprint versus process planning styles; the rational comprehensive versus disjointed incremental planning styles; and the normative versus functional planning styles— are then related to the three basic components of the strategic regional planning system: the type of plan; the type of planning agency; and the type of (ongoing) planning process. The variables that Faludi uses to define these three dimensions are also operationally defined in the context of the Lower Mainland study. Without any a priori hypotheses, the theoretical framework is used in chapter three to descriptively interpret shifts along these dimensions of planning for each of the Lower Mainland study's four time periods. The events and issues of the Lower Mainland study suggest the existence of a long term planning cycle, one driven by both economic growth and interactions between the components of the strategic regional planning system. In the conclusions to the study, chapter four, this cycle is generalized into a pattern of movements along the dimensions of planning and is offered as an initial hypothesis for exploring strategic regional planning in other locations. It was not possible, however, to directly establish causal relationships between the components of the strategic regional planning system because the movements along the dimensions of planning that were used to measure these components were interpreted as 'averages' based on the conflicting impacts of numerous events and issues. While a long term, systems oriented approach to analyzing strategic regional planning is still valid and required, further research requires a more detailed (direct) and integrated classification scheme or model.
Dynamical quantum phase transitions in the dissipative Lipkin-Meshkov-Glick model and proposed realization in optical cavity QED
Creators: name: Morrison, S.
name: Parkins, A. S.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We present an optical cavity QED configuration that is described by a dissipative version of the Lipkin-Meshkov-Glick model of an infinitely coordinated spin system. This open quantum system exhibits both first- and second-order non-equilibrium quantum phase transitions as a single, effective field parameter is varied. Light emitted from the cavity offers measurable signatures of the critical behavior, including that of the spin-spin entanglement.
description: 4 pages, 4 figures, typos corrected and other minor changes
Sender-controlled measurement-device-independent multiparty quantum communication
Creators: name: Wei, Yuyan
name: Wang, Siying
name: Zhu, Yajing
name: Li, Tao
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Multiparty quantum communication is an important branch of quantum networks. It enables private information transmission with information-theoretic security among legitimate parties. We propose a sender-controlled measurement-device-independent multiparty quantum communication protocol. The sender Alice divides a private message into several parts and delivers them to different receivers for secret sharing with imperfect measurement devices and untrusted ancillary nodes. Furthermore, Alice acts as an active controller and checks the security of quantum channels and the reliability of each receiver before she encodes her private message for secret sharing, which makes the protocol convenient for multiparity quantum communication.
Comparative analysis of the transversities and the longitudinally polarized distribution functions of the nucleon
Creators: name: Wakamatsu, M.
Publisher: name: arXiv
Year: 2007
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A first empirical extraction of the transversity distributions for the $u$- and $d$-quarks has been done by Anselmino {\it et al.} based on the combined global analysis of the measured azimuthal asymmetries in semi-inclusive deep inelastic scatterings and those in $e^+ e^- \to h_1 h_2 X$ processes. Although with large uncertainties, the determined transversity distributions already appear to reveal a remarkable qualitative difference with the corresponding longitudinally polarized distributions. We point out that this difference contains very important information on internal spin structure of the nucleon.
description: 12 pages, 2 figures
Searching for mid-IR obscured AGN in the CDF-N
Creators: name: Georgantopoulos, I.
name: Georgakakis, A.
name: Rowan-Robinson, M.
name: Rovilos, E.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The efficiency of mid-infrared selection methods for finding obscured AGN is investigated using data in the \chandra Deep Field North. It is shown that samples of AGN candidates compiled on the basis of mid-infrared colours only suffer substantial contamination from normal galaxies. X-ray stacking analysis reveals a soft mean X-ray spectrum for these sources, consistent with Gamma~2.1. This suggests that star-forming galaxies and not obscured AGN dominate the stacked signal. In contrast AGN selection methods that combine mid-infrared with optical criteria are more successful in finding heavily obscured AGN candidates. A method similar to the one proposed by Fiore et al. (2008) is adopted to select extremely red objects (R-[3.6]>3.7mag) with high 24micron to optical flux ratio (f_24/f_R>1000). About 80% of these sources are not detected at X-ray wavelengths. Stacking the X-ray photons at the positions of these sources shows a flat mean X-ray spectrum (Gamma~0.8), which suggests Compton-thick sources, low-luminosity and moderately obscured (N_H~8e22) AGN, or a combination of the two. The mid-infrared colours and luminosities of these sources are consistent with ULIRGs at z~2, while HST/ACS images, available for the optically brighter of these sources, show disturbed optical morphologies in many of them. The evidence above suggests that this population includes systems in the process of formation.
description: Accepted by A&A
Towards a nonequilibrium thermodynamics: a self-contained macroscopic description of driven diffusive systems
Creators: name: Bertini, L.
name: De Sole, A.
name: Gabrielli, D.
name: Jona-Lasinio, G.
name: Landim, C.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this paper we present a self-contained macroscopic description of diffusive systems interacting with boundary reservoirs and under the action of external fields. The approach is based on simple postulates which are suggested by a wide class of microscopic stochastic models where they are satisfied. The description however does not refer in any way to an underlying microscopic dynamics: the only input required are transport coefficients as functions of thermodynamic variables, which are experimentally accessible. The basic postulates are local equilibrium which allows a hydrodynamic description of the evolution, the Einstein relation among the transport coefficients, and a variational principle defining the out of equilibrium free energy. Associated to the variational principle there is a Hamilton-Jacobi equation satisfied by the free energy, very useful for concrete calculations. Correlations over a macroscopic scale are, in our scheme, a generic property of nonequilibrium states. Correlation functions of any order can be calculated from the free energy functional which is generically a non local functional of thermodynamic variables. Special attention is given to the notion of equilibrium state from the standpoint of nonequilibrium.
description: 21 pages
Convergence of random zeros on complex manifolds
Creators: name: Shiffman, Bernard
Publisher: name: arXiv
Year: 2007
Subjects: subject: Complex Variables (math.CV)
subject: Algebraic Geometry (math.AG)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: We show that the zeros of random sequences of Gaussian systems of polynomials of increasing degree almost surely converge to the expected limit distribution under very general hypotheses. In particular, the normalized distribution of zeros of systems of m polynomials of degree N, orthonormalized on a regular compact subset K of C^m, almost surely converge to the equilibrium measure on K as the degree N goes to infinity.
description: 16 pages
Deep Generative Pattern-Set Mixture Models for Nonignorable Missingness
Creators: name: Ghalebikesabi, Sahra
name: Cornish, Rob
name: Kelly, Luke J.
name: Holmes, Chris
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: We propose a variational autoencoder architecture to model both ignorable and nonignorable missing data using pattern-set mixtures as proposed by Little (1993). Our model explicitly learns to cluster the missing data into missingness pattern sets based on the observed data and missingness masks. Underpinning our approach is the assumption that the data distribution under missingness is probabilistically semi-supervised by samples from the observed data distribution. Our setup trades off the characteristics of ignorable and nonignorable missingness and can thus be applied to data of both types. We evaluate our method on a wide range of data sets with different types of missingness and achieve state-of-the-art imputation performance. Our model outperforms many common imputation algorithms, especially when the amount of missing data is high and the missingness mechanism is nonignorable.
description: International Conference on Artificial Intelligence and Statistics (AISTATS)
Revealing the High-Redshift Star Formation Rate with Gamma-Ray Bursts
Creators: name: Yuksel, Hasan
name: Kistler, Matthew D.
name: Beacom, John F.
name: Hopkins, Andrew M.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: While the high-z frontier of star formation rate (SFR) studies has advanced rapidly, direct measurements beyond z ~ 4 remain difficult, as shown by significant disagreements among different results. Gamma-ray bursts, owing to their brightness and association with massive stars, offer hope of clarifying this situation, provided that the GRB rate can be properly related to the SFR. The Swift GRB data reveal an increasing evolution in the GRB rate relative to the SFR at intermediate z; taking this into account, we use the highest-z GRB data to make a new determination of the SFR at z = 4-7. Our results exceed the lowest direct SFR measurements, and imply that no steep drop exists in the SFR up to at least z ~ 6.5. We discuss the implications of our result for cosmic reionization, the efficiency of the universe in producing stellar-mass black holes, and ``GRB feedback'' in star-forming hosts.
description: 4 pages, 2 figures; ApJ Letters, in press
Observation of a near-threshold enhancement in the e+e- -->Lambda_c+Lambda_c- cross section using initial-state radiation
Creators: name: Pakhlova, G.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We report a measurement of the exclusive e+e- -->Lambda_c+ Lambda_c- cross section as a function of center-of-mass energy near the Lambda_c+ Lambda_c- threshold. A clear peak with a significance of 8.2 sigma is observed in the Lambda_c+ Lambda_c- invariant mass distribution just above threshold. With an assumption of a resonance origin for the observed peak, a mass and width of M=(4634^{+8}_{-7}(stat.)^{+5}_{-8}(sys.))Mev/c2 and Gamma_tot=(92^{+40}_{-24}(stat.)}^{+10}_{-21}(sys.))MeV are determined. The analysis is based on a study of events with initial-state-radiation photons in a data sample collected with the Belle detector at the Υ(4S) resonance and nearby continuum with an integrated luminosity of 695/fb at the KEKB asymmetric-energy e+e- collider.
description: 6 pages, 4 figures, published in PRL, presented at ICHEP2008
Higgs bosons of the NMSSM with explicit CP violation at the ILC
Creators: name: Ham, S. W.
name: Kim, S. H.
name: OH, S. K.
name: Son, D.
Publisher: name: arXiv
Year: 2007
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the Higgs sector of the next-to-minimal supersymmetric standard model (NMSSM) with explicit CP violation at the one-loop level, where the radiative corrections due to the quarks and squarks of the third generation are taken into account. We expect that, within a reasonable region of the parameter space of the present model, at least one of five neutral Higgs bosons may be produced at the future $e^+ e^-$ International Linear Collider (ILC) with $\sqrt{s} = 500$ GeV, with cross section larger than 12 fb, 15 fb, and 1.5 fb, respectively, via the Higgs-strahlung process, the $WW$ fusion process, and the $ZZ$ fusion process. We find that the effect of the CP phase in the present model yields significant influences upon the production cross sections of the five neutral Higgs bosons. We also study the decay modes of the five neutral Higgs bosons to find that their decay widths are similarly affected by the CP phase. Some of the decay modes in the present model behave differently from those of the Standard Model.
description: 36 pages, 18 figures
Long-term X-ray changes in the emission from the anomalous X-ray pulsar 4U 0142+61
Creators: name: Gonzalez, M. E.
name: Dib, R.
name: Kaspi, V. M.
name: Woods, P. M.
name: Tam, C. R.
name: Gavriil, F. P.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present results obtained from X-ray observations of the anomalous X-ray pulsar (AXP) 4U 0142+61 taken between 2000-2007 using XMM-Newton, Chandra and Swift. In observations taken before 2006, the pulse profile is observed to become more sinusoidal and the pulsed fraction increased with time. These results confirm those derived using the Rossi X-ray Timing Explorer and expand the observed evolution to energies below 2 keV. The XMM-Newton total flux in the 0.5-10 keV band is observed to be nearly constant in observations taken before 2006, while an increase of ~10% is seen afterwards and coincides with the burst activity detected from the source in 2006-2007. After these bursts, the evolution towards more sinusoidal pulse profiles ceased while the pulsed fraction showed a further increase. No evidence for large-scale, long-term changes in the emission as a result of the bursts is seen. The data also suggest a correlation between the flux and hardness of the spectrum, with brighter observations on average having a harder spectrum. As pointed out by other authors, we find that the standard blackbody plus power-law model does not provide the best spectral fit to the emission from 4U 0142+61. We also report on observations taken with the Gemini telescope after two bursts. These observations show source magnitudes consistent with previous measurements. Our results demonstrate the wide range of X-ray variability characteristics seen in AXPs and we discuss them in light of current emission models for these sources.
description: 10 pages, 9 figures, in emulateapj style. Submitted to ApJ
METHODOLOGY FOR DEVELOPING CREATIVE THINKING OF STUDENTS OF COMPUTER SCIENCES AND PROGRAMMING TECHNOLOGIES
Creators: name: Shojonov, Muzaffar
Publisher: name: Zenodo
Year: 2023

description: today, computer programs are very important in the educational process. For this reason, this article promotes the technology of developing creative thinking of students of computer science and programming technology, and the educational methodology aimed at developing creative thinking skills of students.
Fast Federated Learning by Balancing Communication Trade-Offs
Creators: name: Nori, Milad Khademi
name: Yun, Sangseok
name: Kim, Il-Min
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Federated Learning (FL) has recently received a lot of attention for large-scale privacy-preserving machine learning. However, high communication overheads due to frequent gradient transmissions decelerate FL. To mitigate the communication overheads, two main techniques have been studied: (i) local update of weights characterizing the trade-off between communication and computation and (ii) gradient compression characterizing the trade-off between communication and precision. To the best of our knowledge, studying and balancing those two trade-offs jointly and dynamically while considering their impacts on convergence has remained unresolved even though it promises significantly faster FL. In this paper, we first formulate our problem to minimize learning error with respect to two variables: local update coefficients and sparsity budgets of gradient compression who characterize trade-offs between communication and computation/precision, respectively. We then derive an upper bound of the learning error in a given wall-clock time considering the interdependency between the two variables. Based on this theoretical analysis, we propose an enhanced FL scheme, namely Fast FL (FFL), that jointly and dynamically adjusts the two variables to minimize the learning error. We demonstrate that FFL consistently achieves higher accuracies faster than similar schemes existing in the literature.
description: 14 pages, 24 figures, accepted for publication in IEEE Transactions on Communications
Cuando la ortodoxia no es lo más relevante: el paisaje de La Gomera y la orientación de sus iglesias
Creators: name: Di Paolo, Adrian
name: Gangui, Alejandro
name: Belmonte, Juan Antonio
name: Betancort, Maria Antonia Perera
Publisher: name: arXiv
Year: 2021
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present a study of the relationship between astronomy and landscape centered on the orientation of Christian churches of the island of La Gomera, located in the Canary Archipelago. The fieldwork consisted of measuring the precise coordinates of 38 churches, which represents almost all of the island's religious constructions, which has an area of approximately 370 km2. For each church, we measured the azimuth and the angular height of the horizon taken in the direction towards which the altar of each temple points. The data obtained were corroborated with digital terrain models frequently used in archaeoastronomical studies. Finally, for the study of the sample, various analyzes were carried out: statistical, calendarical and orographic, trying to find clues that would allow us to understand the pattern of orientations found. From this analysis, we can infer that in some places the canonical tradition of orienting Christian temples in the solar range was respected. Also, it is possible that a few constructions were oriented with imitation patterns of the aborigine cult, especially in solstitial directions. However, we find that the orientation of the majority of the churches is towards the northeast and, in the absence of a better justification, we think that reason should be sought more in the terrestrial landscape than in the celestial one. Judging by the way in which several small groups of temples are distributed, we estimate this unusual pattern of global orientations is motivated by the particular orography of the island. A significant proportion of churches seems to adapt to the characteristics of their sites, orienting themselves according to the numerous geographical features where they are located. These results allow us to conjecture that the known "abrupt nature" of La Gomera is perhaps the main reason for the particular pattern of orientations of its worship sanctuaries.
description: Article in Spanish including 5 figures and 2 tables
Second-harmonic generation and the conservation of spatiotemporal orbital angular momentum of light
Creators: name: Gui, Guan
name: Brooks, Nathan J.
name: Kapteyn, Henry C.
name: Murnane, Margaret M.
name: Liao, Chen-Ting
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Light with spatiotemporal orbital angular momentum (ST-OAM) is a recently discovered type of structured and localized electromagnetic field. This field carries characteristic space-time spiral phase structure and transverse intrinsic OAM. In this work, we present the generation and characterization of the second-harmonic of ST-OAM pulses. We uncovered the conservation of transverse OAM in a second-harmonic generation process, where the space-time topological charge of the fundamental field is doubled along with the optical frequency. Our experiment thus suggests a general ST-OAM nonlinear scaling rule - analogous to that in conventional OAM of light. Furthermore, we observe that the topology of a second-harmonic ST-OAM pulse can be modified by complex spatiotemporal astigmatism, giving rise to multiple phase singularities separated in space and time. Our study opens a new route for nonlinear conversion and scaling of light carrying ST-OAM with the potential for driving other secondary ST-OAM sources of electromagnetic fields and beyond.
description: 15 pages, 6 figures
Oersted fields and current density profiles in spin-torque driven magnetization dynamics -- Finite element modelling of realistic geometries
Creators: name: Hertel, Riccardo
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: The classical impact of electrical currents on magnetic nanostructures is analyzed with numerical calculations of current-density distributions and Oersted fields in typical contact geometries. For the Oersted field calculation, a hybrid finite element / boundary element method (FEM/BEM) technique is presented which can be applied to samples of arbitrary shape. Based on the FEM/BEM analysis, it is argued that reliable micromagnetic simulations on spin-tranfer-torque driven magnetization processes should include precise calculations of the Oersted field, particularly in the case of pillar contact geometries. Similarly, finite-element simulations demonstrate that numerical calculations of current-density distributions are required, e.g., in the case of magnetic strips with an indentation. Such strips are frequently used for the design of devices based on current-driven domain-wall motion. A dramatic increase of the current density is found at the apex of the notch, which is expected to strongly affect the magnetization processes in such strips.
description: 9 pages, 6 figures
Identification of competing ultrafast all-optical switching mechanisms in Si woodpile photonic crystals
Creators: name: Harding, Philip J.
name: Euser, Tijmen G.
name: Vos, Willem L.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a systematic study of ultrafast all-optical switching of Si photonic band gap woodpile crystals using broadband tunable nondegenerate pump-probe spectroscopy. At pump-probe coincidence, we investigate the behavior the differential reflectivity at the blue edge of the stopband for a wide range of pump- and probe frequencies. Both dispersive and absorptive features are observed from the probe spectra at coincidence. As the pump frequency is tuned through half the electronic bandgap of Si, the magnitude of both these features increases. For the first time we unambiguously identify this dispersive effect with the electronic Kerr effect in photonic crystals, and attribute the the absorptive features to nondegenerate two photon absorption. The dispersive and absorptive nonlinear coefficients are extracted, and are found to agree well with literature. Finally, we propose a nondegenerate figure of merit (NFOM), which defines the quality of switching for all nondegenerate optical switching processes.
description: Accepted by JOSA B
Chiglitazar: First Approval
Creators: name: Deeks, Emma D
Publisher: name: Adis Journals
Year: 2021
Subjects: Medicine

description: DeclarationsFunding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Emma Deeks is a contracted employee of Adis International Ltd/Springer Nature and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here
Abstract
Chiglitazar (Bilessglu®) is an orally administered, non-thiazolidinedione small-molecule agonist of α, d and g peroxisome proliferator-activated receptors (PPARs) being developed by Chipscreen Biosciences for the treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis. In October 2021, chiglitazar was approved in China for use as an adjunct to diet and exercise to improve glycaemic control in adult patients with T2D. The drug is also in phase 2 clinical development in China for the treatment of non-alcoholic steatohepatitis. This article summarizes the milestones in the development of chiglitazar leading to this first approval for the treatment of T2D. © Springer Nature Switzerland AG 2021
Atogepant: First Approval
Creators: name: Deeks, Emma D
Publisher: name: Adis Journals
Year: 2021
Subjects: Medicine

description: DeclarationsFunding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Emma Deeks is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here
Abstract
Atogepant (Qulipta™) is an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist being developed by AbbVie for the prophylaxis of migraine. In September 2021, atogepant was approved in the USA for the preventive treatment of episodic migraine in adults. The drug is also in phase 3 clinical development for the preventive treatment of migraine in various other countries. This article summarizes the milestones in the development of atogepant leading to this first approval for the preventive treatment of episodic migraine in adults.© Springer Nature Switzerland AG 2021
On Possible Light-Torsion Mixing in Background Magnetic Field
Creators: name: Kruglov, S. I.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The interaction of the light with propagating axial torsion fields in the presence of an external magnetic field has been investigated. Axial torsion fields appearing in higher derivative quantum gravity possess two states, with spin one and zero, with different masses. The torsion field with spin-0 state is a ghost that can be removed if its mass is infinite. We investigate the possibility when the light mixes with the torsion fields resulting in the effect of vacuum birefringence and dichroism. The expressions for ellipticity and the rotation of light polarization axis depending on the coupling constant and the external magnetic field have been obtained.
description: 12 pages, title changed, shortened journal version, accepted in Eur.Phys.J.C
Bound-free $\mathbf{e}^+ \mathbf{e}^-$ pair creation with a linearly polarized laser field and a nuclear field
Creators: name: Deneke, C.
name: Müller, C.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The process of bound-free pair production of electrons and positrons in combined laser and Coulomb fields is investigated. It is assumed that an ion collides at relativistic speed with an intense x-ray laser beam of linear polarization. The process proceeds nonlinearly due to simultaneous absorption of a few laser photons. The capture of the electron into the ground state and the $L$-shell is considered. The scaling of the total rate, the angular distributions of the emitted positrons and a comparison to the competing free-free channel are surveyed. Numerical results of pair production rates for parameters for the planned x-ray free electron lasers at DESY and SLAC are presented. We find that pair production with these laser facilities can become observable in the near future.
description: 11 pages, 10 figures
Multilayer Resource-aware Partitioning for Fog Application Placement
Creators: name: Samani, Zahra Najafabadi
name: Saurabh, Nishant
name: Prodan, Radu
Publisher: name: arXiv
Year: 2021
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Fog computing emerged as a crucial platform for the deployment of IoT applications. The complexity of such applications requires methods that handle the resource diversity and network structure of Fog devices while maximizing the service placement and reducing resource wastage. Prior studies in this domain primarily focused on optimizing specific application requirements and fail to address the network topology combined with the different types of resources encountered in Fog devices. To overcome these problems, we propose a multilayer resource-aware partitioning method to minimize the resource wastage and maximize the service placement and deadline satisfaction rates in a Fog infrastructure with high multi-user application placement requests. Our method represents the heterogeneous Fog resources as a multilayered network graph and partitions them based on network topology and resource features. Afterward, it identifies the appropriate device partitions for placing an application according to its requirements, which need to overlap in the same network topology partition. Simulation results show that our multilayer resource-aware partitioning method is able to place twice as many services, satisfy deadlines for three times as many application requests, and reduce the resource wastage by up to 15-32 times compared to two availability-aware and resource-aware methods.
description: 13 figures
Flexural performance of foam concrete containing pulverized bone as partial replacement of cement
Creators: name: Ikponmwosa, Efe
name: Funso Falade
name: Fapohunda, Christopher
Publisher: name: Maejo University
Year: 2014
Subjects: foam concrete,cement,pulverised bone,flexural strength

description: 1, 8, Maejo International Journal of Science and Technology
An adaptive radial basis function neural network (RBFNN) control of energy storage system for output tracking of a permanent magnet wind generator
Creators: name: Rahim, Abu H. M. A.
Publisher: name: Maejo University
Year: 2014
Subjects: adaptive control,energy storage control,radial basis function neural network,permanent magnet synchronous generator,wind turbine

description: 1, 8, Maejo International Journal of Science and Technology
Cultivation options for indoor and outdoor growth of Chaetoceros gracilis with airlift photobioreactors
Creators: name: Watadta Ritcharoen
name: Puchong Sriouam
name: Piyanate Nakseedee
name: Patthama Sang
name: Sorawit Powtongsook
name: Kunn Kungvansaichol
name: Prasert Pavasant
Publisher: name: Maejo University
Year: 2014
Subjects: Chaetoceros gracilis,indoor culture,outdoor culture,airlift photobioreacter

description: 1, 8, Maejo International Journal of Science and Technology
In silico PCR Verification and Simplex Real-Time PCR Detection of Methicillin-Resistant Staphylococcus aureus (MRSA) from East Coast Malaysian Clinical Isolates
Creators: name: Zarizal Bin SUHAILI, Saiful Azmi JOHARI
Publisher: name: Walailak University
Year: 2013
Subjects: In-silico PCR, real-time PCR SYBR Green I, methicillin-resistant Staphylococcus aureus (MRSA), staphylocoagulase (coa), nuclease (nuc) and methicillin-resistant (mecA) genes

description: 3, 10, Walailak Journal of Science and Technology
Influence of Plastic Deformation on the Properties of 6066 Heat Treatable Aluminum Alloys
Creators: name: Emad Abdelraouf BADAWI, Mmdouh ABDEL-NASER
Publisher: name: Walailak University
Year: 2013
Subjects: Plastic deformation, age hardening, aluminum alloys, HV values, positron annihilation lifetime spectroscopy

description: 3, 10, Walailak Journal of Science and Technology
Generalized Fractional Integration of the H-Function Involving General Class of Polynomials
Creators: name: Dinesh KUMAR, Praveen AGARWAL
Publisher: name: Walailak University
Year: 2014
Subjects: Generalized fractional calculus operators, H-function, Generalized Wright hypergeometric function, Generalized Wright-Bessel function, the poly-logarithm function, Generalized Riemann Zeta function and Whittaker function

description: 12, 11, Walailak Journal of Science and Technology
SOCIO-PEDAGOGICAL SIGNIFICANCE OF THE DEVELOPMENT OF COGNITIVE COMPETENCE OF TEACHERS OF FUTURE MUSIC EDUCATION
Creators: name: Abdullayev, Sardorbek
Publisher: name: Zenodo
Year: 2023

description: The article presents information about the cognitive competence of music education teachers, their ability to obtain information in the educational process, organize their activities in educational systems, and provide themselves with new information. In this process of music education, it was suggested that the cognitive psychology of students should be improved through effective pedagogical approaches in order to regularly update their professional knowledge, gradually develop skills, and subsequently teach as music education. teachers, solve problems in their imaginary thinking. Music education also plays an important role in social and personal development. Cognitive competence is important in this topic, and competence ensures that students can easily acquire new knowledge from teachers. The article is devoted to these topical issues.
An economic assessment of ecological practices in Scotland
Creators: name: Shrestha, Shailesh
name: Thompson, Bethan
name: Toma, Luiza
name: Ferreira, Joana
name: Barnes, Andrew
Publisher: name: Zenodo
Year: 2021
Subjects: Ecological Practices; ScotFarm; Scotland

description: Early adoption of ecological management practices by farmers is a potential route to achieving sustainable and greener goals for agriculture. This briefing note outlines an economic assessment of four different ecological practices on Scottish livestock farms. The ecological practices used are; ecological area, reducing farm inputs, organic adoption and agro-forestry. The results suggest that ecological area and reduced farm inputs have potential financial benefits on farms and can be easily adopted by farmers. The organic and agro-forestry systems, however, require capital investment to establish and hence provide a challenging prospect of adoption without a provision of financial support
Neurocritical Care Practice Among Surgical Intensivists
Creators: name: Patel, Purvi Pravinchandra
Publisher: name: University of Illinois at Chicago
Year: 2024

description: Neurocritical Care Practice Among Surgical Intensivists

Introduction: Trauma surgeons manage patients with neurocritical care (NCC) diagnoses, including traumatic brain injury (TBI), spine injury, and postoperative issues. Training and practice in NCC are variably incorporated in Surgical Critical Care (SCC). In 2021, a NCC board certification opened but no reported data on this program from a surgical perspective exists.

Methods: Demographic and NCC exam results for surgical intensivists was obtained from the American Board of Surgery (ABS). Also, an electronic survey regarding demographics, NCC practice, clinical scenarios, and opinions regarding the pursuit and utility of NCC certification was distributed to a cohort of SCC diplomats.

Results: 209 individuals participated in the survey and were included for analysis. Majority identified as male (59%), White (76%), and were double-board certified in General Surgery and SCC (93%). Fifty-eight (28%) had obtained (n=30) or are pursuing (n=28) NCC certification and were included as the NCC cohort. Many significant practice differences and significant differences in comfort with NCC diseases existed between the NCC and SCC cohorts. Most of the NCC cohort believe their NCC skills have improved and 79% recommend pursuing NCC certification. ABS data showed 190 surgeons have taken the NCC exam. Most were part of the practice pathway, male (69%), and on median 8 years from SCC certification. Cumulative pass rate for surgeons was significantly lower (40%) versus the 73% overall pass rate for 2021 (p<0.01).

Conclusions: While NCC is an essential part of SCC practice, NCC certification may benefit only a small cohort. All surgeons were comfortable managing trauma related neurological disorders. NCC diseases that showed increased comfort by the NCC cohort were infrequently managed by most surgical intensivists. Overall exam pass rates for surgeons are lower than for non-surgical NCC specialists, highlighting the need for additional NCC exposure in fellowship and post-graduate practice.
“…then came Cisco, and the rest is history”: a ‘history friendly’ model of the Local Area Networking industry
Creators: name: Fontana, Roberto
name: Zirulia, Lorenzo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: SECS-P/01 Economia politica

description: We study the role that switching costs, compatibility, and mergers and acquisitions, play in influencing the evolution of a multi-market industry. By looking at the case of the Local Area Networking industry, we propose a ‘history friendly model’ to replicate its evolution during the 1990s. Our model explains how a firm can start from a dominant position in one of the existing markets and exploit switching costs and compatibility to enter a new market when it opens. Mergers and acquisitions also play an important role as the new market is pioneered by a new start-up, which is soon acquired by the dominant incumbent. As a result of the acquisition, the acquiring firm becomes leader also in the new market.
Which Ambient Spaces Admit Isoperimetric Inequalities for Submanifolds?
Creators: name: White, Brian
Publisher: name: arXiv
Year: 2008
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C42, 49Q05

description: We give simple conditions on an ambient manifold that are necessary and sufficient for isoperimetric inequalities (for submanifolds) to hold.
description: 13 pages. Minor revisions made September 6, 2008 (some typos corrected, terminology changed slightly.) Three typos corrected on October 11, 2008. On Dec 16, a few further minor changes. In particular, an open problem added (2.8)
The precision electroweak data in warped extra-dimension models
Creators: name: Bouchart, Charles
name: Moreau, Grégory
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Randall-Sundrum scenario with Standard Model fields in the bulk and a custodial symmetry is considered. We determine the several minimal quark representations allowing to address the anomalies in the forward-backward b-quark asymmetry A^b_FB, while reproducing the bottom and top masses via wave function overlaps. The calculated corrections of the Zbb coupling include the combined effects of mixings with both Kaluza-Klein excitations of gauge bosons and new b'-like states. It is shown that the mechanism, in which the left-handed doublet of third generation quarks results from a mixing on the UV boundary of introduced fields Q_1L and Q_2L, is necessary for phenomenological reasons. Within the obtained models, both the global fit of R_b with A^b_FB [at the various center of mass energies] and the fit of last precision electroweak data in the light fermion sector can simultaneously be improved significantly with respect to the pure Standard Model case, for M_KK = 3,4,5 TeV (first KK gauge boson) and a best-fit Higgs mass m_h > 115 GeV i.e. compatible with the LEP2 direct limit. The quantitative analysis of the oblique parameters S,T,U even shows that heavy Higgs mass values up to ~500 GeV may still give rise to an acceptable quality of the electroweak data fit, in contrast with the Standard Model. The set of obtained constraints on the parameter space, derived partly from precision electroweak data, is complementary of a future direct exploration of this parameter space at the LHC. In particular, we find that custodians, like b' modes, can be as light as ~1200 GeV i.e. a mass lying possibly in the potential reach of LHC.
description: 24 pages, 8 figures. Added references, corrected typos and Higgs mass dependence discussion completed
Black Hole Magnetic Fields and Their Imprint on Circular Polarization Images
Creators: name: Ricarte, Angelo
name: Qiu, Richard
name: Narayan, Ramesh
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The circular polarization of black hole accretion flows can encode properties of the underlying magnetic field structure. Using general relativistic magnetohydrodynamics (GRMHD) simulations, we study the imprint of magnetic field geometry on circular polarization images potentially observable by the Event Horizon Telescope (EHT). We decompose images into the different mechanisms that generate circular polarization in these models, which are sensitive to both the line of sight direction and twist of the magnetic field. In these models, a stable sign of the circular polarization over time, as observed for several sources, can be attributed to a stability of these properties. We illustrate how different aspects of a generic helical magnetic field geometry become imprinted on a circular polarization image. We also identify novel effects of light bending that affect the circular polarization image on event horizon scales. One consequence is the sign flipping of successive photon rings in face-on systems, which if observable and uncorrupted by Faraday rotation, can directly encode the handedness of the approaching magnetic field.
description: 20 pages, 19 figures, in review with MNRAS
I.C.E.: An Ultra-Cold Atom Source for Long-Baseline Interferometric Inertial Sensors in Reduced Gravity
Creators: name: Varoquaux, Gaël
name: Zahzam, Nassim
name: Chaibi, Walid
name: Clément, Jean-François
name: Carraz, Olivier
name: Brantut, Jean-Philippe
name: Nyman, Robert A.
name: Santos, Franck Pereira Dos
name: Mondin, Linda
name: Rouzé, Michel
name: Bidel, Yannick
name: Bresson, Alexandre
name: Landragin, Arnaud
name: Bouyer, Philippe
Publisher: name: arXiv
Year: 2007
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: The accuracy and precision of current atom-interferometric inertialsensors rival state-of-the-art conventional devices using artifact-based test masses . Atomic sensors are well suited for fundamental measurements of gravito-inertial fields. The sensitivity required to test gravitational theories can be achieved by extending the baseline of the interferometer. The I.C.E. (Interférométrie Cohérente pour l'Espace) interferometer aims to achieve long interrogation times in compact apparatus via reduced gravity. We have tested a cold-atom source during airplane parabolic flights. We show that this environment is compatible with free-fall interferometric measurements using up to 4 second interrogation time. We present the next-generation apparatus using degenerate gases for low release-velocity atomic sources in space-borne experiments.