cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Development, validation, and application of a multi-method for the determination of mycotoxins, plant growth regulators, tropane alkaloids, and pesticides in cereals by two-dimensional liquid chromatography tandem mass spectrometry
Creators: name: Rausch, Ann-Kristin
name: Brockmeyer, Robert
name: Schwerdtle, Tanja
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften

description: Mycotoxins and pesticides regularly co-occur in agricultural products worldwide. Thus, humans can be exposed to both toxic contaminants and pesticides simultaneously, and multi-methods assessing the occurrence of various food contaminants and residues in a single method are necessary. A two-dimensional high performance liquid chromatography tandem mass spectrometry method for the analysis of 40 (modified) mycotoxins, two plant growth regulators, two tropane alkaloids, and 334 pesticides in cereals was developed. After an acetonitrile/water/formic acid (79:20:1, v/v/v) multi-analyte extraction procedure, extracts were injected into the two-dimensional setup, and an online clean-up was performed. The method was validated according to Commission Decision (EC) no. 657/2002 and document N° SANTE/12682/2019. Good linearity (R2 > 0.96), recovery data between 70-120%, repeatability and reproducibility values < 20%, and expanded measurement uncertainties < 50% were obtained for a wide range of analytes, including very polar substances like deoxynivalenol-3-glucoside and methamidophos. However, results for fumonisins, zearalenone-14,16-disulfate, acid-labile pesticides, and carbamates were unsatisfying. Limits of quantification meeting maximum (residue) limits were achieved for most analytes. Matrix effects varied highly (−85 to +1574%) and were mainly observed for analytes eluting in the first dimension and early-eluting analytes in the second dimension. The application of the method demonstrated the co-occurrence of different types of cereals with 28 toxins and pesticides. Overall, 86% of the samples showed positive findings with at least one mycotoxin, plant growth regulator, or pesticide.
description: Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1365
Prior Irradiation Results in Elevated Programmed Cell Death Protein 1 (PD-1) in T Cells
Creators: name: Deguan Li
name: Renxiang Chen
name: Wang, Yi-Wen
name: Fornace, Albert J.
name: Heng-Hong Li
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Purpose: In this study we addressed the question whether radiation-induced adverse effects on T cell activation are associated with alterations of T cell checkpoint receptors. Materials and Methods: Expression levels of checkpoint receptors on T cell subpopulations were analyzed at multiple post-radiation time points ranging from one to four weeks in mice receiving a single fraction of 1 or 4 Gy of γ-ray. T cell activation associated metabolic changes were assessed. Results: Our results showed that prior irradiation resulted in significant elevated expression of Programmed Cell Death Protein 1 (PD-1) in both CD4+ and CD8+ populations, at all three post-radiation time points. T cells with elevated PD-1 mostly were either central memory or naïve cells. In addition, the feedback induction of PD-1 expression in activated T cells declined after radiation. Conclusions: Taken together, the elevated PD-1 level observed at weeks after radiation exposure is connected to T cell dysfunction. Recent preclinical and clinical studies have showed that a combination of radiotherapy and T cell checkpoint blockade immunotherapy including targeting the PD-L1/PD-1 axis may potentiate the antitumor response. Understanding the dynamic changes in PD-1 levels in T cells after radiation should help in the development of a more effective therapeutic strategy.
Lettre de Pierre Cusson à Jean-François Séguier, 1777-07-30
Creators: name: Cusson, Pierre
name: Cusson, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: botanique

description: [transcription]Montpellier le 30 juillet 1777

Mon cher Maître

La présente vous sera rendue par Mr Broussonnet fils, étudiant en médecine, jeune homme très zélé pour l’histoire naturelle, bon botaniste et bon écologiste autant que son âge le comporte. Il est très avide d’instruction et d’autopsie. Vous l’attirés à Nîmes où il passera plusieurs jours ; il ne pouvait choisir de ville où il peut satisfaire plus pleinement l’envie qu’il a de s’instruire et de voir ; il est infatigable et il iroit au bou du monde pour colliger. C’est le fils de Mr Broussonnet professeur en médecine, le meilleur de mes amis. Je prens la liberté de vous le recommander et de vous prier d’avoir des bontés pour luy. Je ne vous exhorte pas à ouvrir en sa faveur votre sein fécond ; il est dans l’habitude de verser pour tout le monde, et vous êtes la preuve vivante de cet [fol. 160v] adage théologique, nunc bonum est ex se communicationum. J’ose espérer que vous aurés quelque égard à ma recommandation.
La pratique etouffe la botanique. Les actes de mon fils ainé qui est docteur en médecine et membre de la société royale des sciences et les malades m’ont empêché de donner un coup d’œil sur les ombellifères depuis 8 mois ; je vais les reprendre et finir le peu qui me reste à faire. Je n’espère plus les cayers des ombellifères de Tournefort dont on me berce depuis 3 ans ; ainsy je finiray crainte de ne pouvoir finir : j’aurais voulu déterminer toutes les ombellifères orientales de notre coryphée ; mais on s’y oppose. Tant pis pour ceux qui me brident, je feray mention de celles que j’ay et temoigneray au public mes regrets si je ne les lui présente pas toutes ; il y a des hommes incapables de faire le bien et qui sont faits pour jetter les entraves à ceux qui veulent le faire.
[fol. 161] Je vous souhaite force santé ; un peu de part toujours dans votre précieuse amitié. J’ay l’honneur d’être avec autant d’estime que de dévouement
Mon cher Maître
Votre très humble et très obéissant serviteur
Cusson méd.

[fol. 161 v]
A Monsieur
Monsieur Séguier
A Nîmes
description: Source: [établissement de conservation] Nîmes, Bibliothèque Carré d'Art [cote] ms. 94, fol. 160-161
The dark Stodolsky effect: constraining effective dark matter operators with spin-dependent interactions
Creators: name: Rostagni, Guillaume
name: Shergold, Jack D.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present a comprehensive discussion of the Stodolsky effect for dark matter (DM), and discuss two techniques to measure the effect and constrain the DM parameter space. The Stodolsky effect is the spin-dependent shift in the energy of a Standard Model (SM) fermion sitting in a bath of neutrinos. This effect, which scales linearly in the effective coupling, manifests as a small torque on the SM fermion spin and has historically been proposed as a method of detecting the cosmic neutrino background. We generalise this effect to DM, and give expressions for the induced energy shifts for DM candidates from spin-$0$ to spin-$\frac 32$, considering all effective operators up to mass dimension-6. In all cases, the effect scales inversely with the DM mass, but requires an asymmetric background. We show that a torsion balance experiment is sensitive to energy shifts of $ΔE \gtrsim 10^{-28}\,\mathrm{eV}$, whilst a more intricate setup using a SQUID magnetometer is sensitive to shifts of $ΔE \gtrsim 10^{-32}\,\mathrm{eV}$. Finally, we compute the energy shifts for a model of scalar DM, and demonstrate that the Stodolsky effect can be used to constrain regions of parameter space that are not presently excluded.
description: 34 pages, 2 figures
Structural insights into the binding mode of flavonols with the active site of matrix metalloproteinase-9 through molecular docking and molecular dynamic simulations studies
Creators: name: Dhinakararajan Pradiba
name: Murali Aarthy
name: Velu Shunmugapriya
name: Singh, Sanjeev Kumar
name: Vasanthi, Mani
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Cartilage degradation in rheumatoid arthritis is mediated principally by the collagenases and gelatinases. Gelatinase B (also called matrix metalloproteinase 9 – MMP-9), is a valid target molecule which is known to participate in cartilage degradation as well as angiogenesis associated with the disease and inhibition of its activity shall prevent cartilage damage and angiogenesis. The focus of this study is to investigate the possibilities of MMP-9 inhibition by flavonol class of bioflavonoids by studying their crucial binding interactions at the active site of MMP 9 using molecular docking (Glide XP and QPLD) and further improvisation by post-docking MM-GBSA and molecular dynamic (MD) simulations. The results show that flavonols can convincingly bind to active site of MMP-9 as demonstrated by their stable interactions at the S1′ specificity pocket and favourable binding energies. Gossypin has emerged as a promising candidate with a docking score of −14.618 kcal/mol, binding energy of −79.97 kcal/mol and a stable MD pattern over 15 ns. In addition, interaction mechanisms with respect to catalytic site zinc are also discussed. Further, the drug-like characters of the ligands were also analysed using ADME analysis.
DNS of Unsteady Flame-Wall Interaction
Creators: name: Zhang, Feichi
name: Zirwes, Thorsten
name: Häber, Thomas
name: Bockhorn, Henning
name: Trimis, Dimosthenis
name: Wang, R.
name: Suntz, R.
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2021

description: Direct numerical simulations (DNS) of unsteady side-wall quenching (SWQ) of stoichiometric premixed methane/air flames operated at atmospheric condition have been conducted. Objective of the work is to study the effect of transient, relative motion between the flame and the wall on the flame-wall interaction (FWI). A W-shaped plane-jet flame is considered, which is bounded in its lateral direction by two side walls. The unsteady motion of the flame is generated by using an oscillatory wall moving in its normal direction, with a pre-defined frequency $f$ and stroke length $L$ (distance between min/max wall normal locations). It has been found that the time-mean quenching distance $d_q$ and wall heat flux $\overline{\dot{q}}_w$ increase strongly with $f$ and $L$. In the case of weak flow disturbances with small $f$ and $L$, $d_q$ and $\overline{\dot{q}}_w$ yield a quasi-linear correlation with each other. However, a hysteresis loop for the correlation of $d_q$ and $\overline{\dot{q}}_w$ has been confirmed with increased $f$ and $L$, which is attributed to the delayed response of the flame to the unsteady fluctuations of the flow and temperature fields. The behaviour of the flow-flamewall interaction has been revealed: the unsteady flow disturbance results in a relative motion between the flame and the wall. As a consequence, $d_q$ fluctuates in time, which leads to a different $\overline{\dot{q}}_w$ or heat loss sensed by the flame. The flame adjusts its dynamics (movement) with updated $\overline{\dot{q}}_w$ and the loop starts over again. The results indicate the strong impact of the unsteady flow on the FWI phenomena, which leads to delayed response of FWI to the unsteadily moving flame and modified quenching distance as well as wall heat fluxes.
Supplementary Table S1 from Climate and foraging mode explain interspecific variation in snake metabolic rates
Creators: name: Andréaz Dupoué
name: Brischoux, François
name: Lourdais, Olivier
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Full dataset reporting the oxygen consumption (VO2) measured at different trial temperatures (Ttrial) and body mass in 90 snake species from the 76 studies. Table also shows the metabolic state of snakes (resting or standard metabolic rate, RMR or SMR), the respirometry method (closed or open-flow respirometry) used in the study, the foraging mode (F-M) of each species, its origin, and the selected town to assess the climate temperature (Tclim) and total precipitation (Ptotal).
Table S2 from Climate and foraging mode explain interspecific variation in snake metabolic rates
Creators: name: Andréaz Dupoué
name: Brischoux, François
name: Lourdais, Olivier
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: AICc based comparisons of phylogenetic signal (λ = 0 for star phylogeny and λ = 1 for original phylogeny) between models including snake VO2 as dependent variable, and mass, Ttrial, metabolic state, foraging mode, Tclim, and Ptotal as explanatory factors or covariates and species identity as random effect. Table reports the AICc and the log likelihood for each model (final model obtained for λ = 0.2). See text for details.
Additional file 1 of Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
Creators: name: Wan, Zi-ming
name: Hu, Bo
name: Lai, Qi-quan
name: Gao, Xue-jing
name: Tu, Bo
name: Zhou, Yu
name: Zhao, Wen-bo
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1.
Hardware-Impaired Rician-Faded Cell-Free Massive MIMO Systems With Channel Aging
Creators: name: Tentu, Venkatesh
name: Amudala, Dheeraj N
name: Chattopadhyay, Anish
name: Budhiraja, Rohit
Publisher: name: arXiv
Year: 2023
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We study the impact of channel aging on the uplink of a cell-free (CF) massive multiple-input multiple-output (mMIMO) system by considering i) spatially-correlated Rician-faded channels; ii) hardware impairments at the access points and user equipments (UEs); and iii) two-layer large-scale fading decoding (LSFD). We first derive a closed-form spectral efficiency (SE) expression for this system, and later propose two novel optimization techniques to optimize the non-convex SE metric by exploiting the minorization-maximization (MM) method. The first one requires a numerical optimization solver, and has a high computation complexity. The second one with closed-form transmit power updates, has a trivial computation complexity. We numerically show that i) the two-layer LSFD scheme effectively mitigates the interference due to channel aging for both low- and high-velocity UEs; and ii) increasing the number of AP antennas does not mitigate the SE deterioration due to channel aging. We numerically characterize the optimal pilot length required to maximize the SE for various UE speeds. We also numerically show that the proposed closed-form MM optimization yields the same SE as that of the first technique, which requires numerical solver, and that too with a much reduced time-complexity.
description: This work has been submitted to the IEEE Transactions on Communications for possible publication, 32 pages, 14 figures
D.9.7: Final report on communication, dissemination & liaison
Creators: name: Brevi, Daniele
name: Bonetto, Edoardo
name: Krikigianni, Elena
name: Pilic, Tomislav
name: Krimpa, Irini
name: Todesco, Elisa
name: Buenavida, Lidia
Publisher: name: Zenodo
Year: 2022

description: Context:  Connected and automated vehicles are a key focal point of ITS research. To enable and accelerate their deployment in our everyday life, ICT is a prerequisite; this is the frame in which ICT4CART project places itself. Despite the significant advances in the telecom and IT industries, several ICT challenges related to connectivity, data management, cyber-security and ICT infrastructure architectures still exist, and need to be addressed to enable road vehicle automation. ICT4CART aimed to address the gaps to deployment, bringing together over 42 months key players from the automotive, telecom and IT industries to shape the ICT landscape for Connected and Automated Road Transport and to boost EU competitiveness and innovation in this area. Project scope ICT4CART’s main objective was to design, implement and test in real-life conditions a versatile ICT infrastructure that will enable the transition towards higher levels of automation (up to L4) by addressing existing gaps and working with specific key ICT elements, namely hybrid connectivity, data management, cyber-security, data privacy and accurate localisation. ICT4CART built on high-value use cases (urban and highway), which have been demonstrated and validated in real-life conditions at ICT4CART test sites in Austria, Germany and Italy (cfr.D7.3, D7.4, D7.5). Significant effort has been put into cross-border interoperability through the set-up of a separate test site at the Italian-Austrian border (cfr. D7.6). D9.7 Final report on communication, dissemination & liaison This document provides ICT4CART’s final report on communication, dissemination & liaison activities carried out by the whole consortium throughout the entirety of the project. It includes a detailed overview on all communication and dissemination actions that have been performed by the ICT4CART consortium from M1 until M42 (timeline moved from M36 to M42 due to the official extension obtained by the project), benchmarking the performances and the achievements of ICT4CART’s communication, dissemination and liaison’s efforts against the KPIs set in D9.1 (M6).
title: ADCO, Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Cart. 29 (G 134), 996 folios, f. 0641
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0641, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0641, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Supplementary code from Climate and foraging mode explain interspecific variation in snake metabolic rates
Creators: name: Andréaz Dupoué
name: Brischoux, François
name: Lourdais, Olivier
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Supplementary code supporting the statistical analyses from Dupoué et al. Climate and foraging mode explain interspecific variation in snake metabolic rates
Efficient computation of the sinc matrix function for the integration of second-order differential equations
Creators: name: Aceto, Lidia
name: Durastante, Fabio
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65L06, 15A16, 41A20

description: This work deals with the numerical solution of systems of oscillatory second-order differential equations which often arise from the semi-discretization in space of partial differential equations. Since these differential equations exhibit (pronounced or highly) oscillatory behavior, standard numerical methods are known to perform poorly. Our approach consists in directly discretizing the problem by means of Gautschi-type integrators based on $\operatorname{sinc}$ matrix functions. The novelty contained here is that of using a suitable rational approximation formula for the $\operatorname{sinc}$ matrix function to apply a rational Krylov-like approximation method with suitable choices of poles. In particular, we discuss the application of the whole strategy to a finite element discretization of the wave equation.
GREAT Score: Global Robustness Evaluation of Adversarial Perturbation using Generative Models
Creators: name: Li, Zaitang
name: Chen, Pin-Yu
name: Ho, Tsung-Yi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Current studies on adversarial robustness mainly focus on aggregating local robustness results from a set of data samples to evaluate and rank different models. However, the local statistics may not well represent the true global robustness of the underlying unknown data distribution. To address this challenge, this paper makes the first attempt to present a new framework, called GREAT Score , for global robustness evaluation of adversarial perturbation using generative models. Formally, GREAT Score carries the physical meaning of a global statistic capturing a mean certified attack-proof perturbation level over all samples drawn from a generative model. For finite-sample evaluation, we also derive a probabilistic guarantee on the sample complexity and the difference between the sample mean and the true mean. GREAT Score has several advantages: (1) Robustness evaluations using GREAT Score are efficient and scalable to large models, by sparing the need of running adversarial attacks. In particular, we show high correlation and significantly reduced computation cost of GREAT Score when compared to the attack-based model ranking on RobustBench (Croce,et. al. 2021). (2) The use of generative models facilitates the approximation of the unknown data distribution. In our ablation study with different generative adversarial networks (GANs), we observe consistency between global robustness evaluation and the quality of GANs. (3) GREAT Score can be used for remote auditing of privacy-sensitive black-box models, as demonstrated by our robustness evaluation on several online facial recognition services.
description: 10 pages, 13 figures
Impact of membrane partitioning on the spatial structure of an S-type cobra cytotoxin
Creators: name: Dubovskii, Peter V.
name: Dubinnyi, Maxim A.
name: Volynsky, Pavel E.
name: Pustovalova, Yulia E.
name: Konshina, Anastasia G.
name: Utkin, Yuri N.
name: Arseniev, Alexander S.
name: Efremov, Roman G.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: Cobra cytotoxins (CTs) belong to the three-fingered protein family. They are classified into S- and P-types, the latter exhibiting higher membrane-perturbing capacity. In this work, we investigated the interaction of CTs with phospholipid bilayers, using coarse-grained (CG) and full-atom (FA) molecular dynamics (MD). The object of this work is a CT of an S-type, cytotoxin I (CT1) from N.oxiana venom. Its spatial structure in aqueous solution and in the micelles of dodecylphosphocholine (DPC) were determined by 1H-NMR spectroscopy. Then, via CG- and FA MD-computations, we evaluated partitioning of CT1 molecule into palmitoyloleoylphosphatidylcholine (POPC) membrane, using the toxin spatial models, obtained either in aqueous solution, or detergent micelle. The latter model exhibits minimal structural changes upon partitioning into the membrane, while the former deviates from the starting conformation, loosing the tightly bound water molecule in the loop-2. These data show that the structural changes elicited by CT1 molecule upon incorporation into DPC micelle take place likely in the lipid membrane, although the mode of the interaction of this toxin with DPC micelle (with the tips of the all three loops) is different from its mode in POPC membrane (primarily with the tip of the loop-1 and both the tips of the loop-1 and loop-2).
What is all this fuss about Tus? Comparison of recent findings from biophysical and biochemical experiments
Creators: name: Bojk A. Berghuis
name: Vlad-Stefan Raducanu
name: Elshenawy, Mohamed M.
name: Jergic, Slobodan
name: Depken, Martin
name: Dixon, Nicholas E.
name: Hamdan, Samir M.
name: Dekker, Nynke H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Evolutionary Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Synchronizing the convergence of the two-oppositely moving DNA replication machineries at specific termination sites is a tightly coordinated process in bacteria. In Escherichia coli, a “replication fork trap” – found within a chromosomal region where forks are allowed to enter but not leave – is set by the protein–DNA roadblock Tus–Ter. The exact sequence of events by which Tus–Ter blocks replisomes approaching from one direction but not the other has been the subject of controversy for many decades. Specific protein–protein interactions between the nonpermissive face of Tus and the approaching helicase were challenged by biochemical and structural studies. These studies show that it is the helicase-induced strand separation that triggers the formation of new Tus–Ter interactions at the nonpermissive face – interactions that result in a highly stable “locked” complex. This controversy recently gained renewed attention as three single-molecule-based studies scrutinized this elusive Tus–Ter mechanism – leading to new findings and refinement of existing models, but also generating new questions. Here, we discuss and compare the findings of each of the single-molecule studies to find their common ground, pinpoint the crucial differences that remain, and push the understanding of this bipartite DNA–protein system further.
Improving mechanical properties of high-temperature resistant carbon fiber/phthalonitrile composites via surface modification: a comparative study on modification methods
Creators: name: Yin, Changping
name: Zhang, Yefan
name: Liao, Wei
name: Liu, Jiao
name: Wu, Nan
name: Xing, Suli
name: Tang, Jun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: The interfacial bonding is of essential importance for the mechanical properties of high-temperature resistant carbon fiber/phthalonitrile composite materials. To promote the interfacial adhesion of carbon fiber/phthalonitrile composites, three surface modification methods, namely HP302 sizing, diazotization modification, and oxidation-diazotization modification, were applied and compared. The results showed that the de-sizing treatment barely affected the mechanical properties of the composites. Both re-sizing with HP302 agent and diazotization modification improved the mechanical properties, while the mechanical properties were drastically decreased via the oxidation-diazotization modification. Among these surface modification methods, the diazotization treatment derived the best mechanical properties of carbon fiber/phthalonitrile composites both at room and high temperature. Specifically, the flexural strengths were 345 MPa (RT), 525 MPa (300°C), and 442 MPa (400°C), which were 47%, 302%, and 281% higher than those of the pristine composites. The interlaminar shear strengths were 33 MPa (RT), 26 MPa (300°C), and 27 MPa (400°C), which were all over twofold than those of the original counterparts.
HOW TECHNOLOGY IMPACTS STUDENT ACHIEVEMENT IN THE CLASSROOM
Creators: name: Gerardot, Amanda Lynn
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 390306
subject: Secondary education

description: The integration of technology in classrooms has become increasingly prevalent, presenting both opportunities and challenges for educators. This study examines the impact of technology on student performance and behavior, particularly in seventh and eighth-grade classrooms. The COVID-19 pandemic accelerated the shift to online learning, raising concerns about learning loss and disparities in access to technology. Using a needs-based assessment survey, this research investigates teachers' perceptions of technology's effects on student engagement, academic achievement, and retention of curriculum content. The study explores the positive and negative implications of technology use, as well as non-technological strategies employed by teachers to support student learning. Findings reveal that while technology offers benefits such as student-centered education and immediate feedback, it also poses challenges such as distractions and decreased engagement. The study underscores the importance of understanding how technology impacts student learning and behavior and provides insights for developing effective intervention strategies. By considering the perspectives of educators, this research contributes to the ongoing dialogue on technology integration in education and informs evidence-based practices for promoting student success in technology-rich classrooms.
Roles of different organic-inorganic hybrid interfaces in enhancing the mechanical properties of continuous basalt fiber/epoxy composites
Creators: name: Yan, Zhenhan
name: Zhang, Shengchang
name: Zhao, Yingying
name: Xu, Qibin
name: Jiang, Mengjin
name: Liu, Pengqing
name: Zhou, Shiyi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Space Science
Physical Sciences not elsewhere classified
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy
Hematology

description: In order to enhance the interfacial adhesion between continuous basalt fibers (CBFs) and epoxy (EP) matrix and the mechanical properties of resultant composites, the organic – inorganic hybrid compatibilization layer (OIHCL) composed of flexible 1,6-hexanediol diglycidyl ether (HDE) chains and rigid nano-silica (SiO2) is grafted on CBFs surface. With increasing the SiO2 content in the OIHCL, the structure and composition of the OIHCL change from a single layer composed of a well-dispersed SiO2 phase and continuous HDE phase to a double layer composed of an HDE/SiO2 inner-layer and aggregated SiO2 outer-layer. And, the effects of different OIHCLs on the mechanical performances of resultant composite are studied in details. The results show that the single-layer OIHCL exhibits stronger reinforcing effects in the interfacial shear strength (IFSS), tensile strength, and flexural strength of resultant composite. For example, the IFSS, tensile strength, and flexural strength of the CBFs-g-12.5%-(HDE/SiO2)/EP composite can reach 47.1 MPa, 466.1 MPa, and 660.5 MPa, respectively. Furthermore, the impact strength of the CBF/EP composites can be effectively enhanced by only grafting a flexible HDE layer on CBF surfaces. Finally, the aggregated SiO2 derived from the outer-layer of double-layer OIHCLs can deteriorate the interfacial adhesion, and all mechanical performances of resultant composites.
ML-based Approaches for Wireless NLOS Localization: Input Representations and Uncertainty Estimation
Creators: name: Darbinyan, Rafayel
name: Khachatrian, Hrant
name: Mkrtchyan, Rafayel
name: Raptis, Theofanis P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The challenging problem of non-line-of-sight (NLOS) localization is critical for many wireless networking applications. The lack of available datasets has made NLOS localization difficult to tackle with ML-driven methods, but recent developments in synthetic dataset generation have provided new opportunities for research. This paper explores three different input representations: (i) single wireless radio path features, (ii) wireless radio link features (multi-path), and (iii) image-based representations. Inspired by the two latter new representations, we design two convolutional neural networks (CNNs) and we demonstrate that, although not significantly improving the NLOS localization performance, they are able to support richer prediction outputs, thus allowing deeper analysis of the predictions. In particular, the richer outputs enable reliable identification of non-trustworthy predictions and support the prediction of the top-K candidate locations for a given instance. We also measure how the availability of various features (such as angles of signal departure and arrival) affects the model's performance, providing insights about the types of data that should be collected for enhanced NLOS localization. Our insights motivate future work on building more efficient neural architectures and input representations for improved NLOS localization performance, along with additional useful application features.
description: This work has been submitted to the IEEE for possible publication. Work partly supported by the RA Science Committee grant No. 22rl-052 (DISTAL) and the EU under Italian National Recovery and Resilience Plan of NextGenerationEU on "Telecommunications of the Future" (PE00000001 - program "RESTART")
XURSHID DO'STMUHAMMADNING  "OROMKURSI"  QISSASIDA RAMZIY QARASHLAR
Creators: name: Xajikurbanova, Nilufar
Publisher: name: Zenodo
Year: 2024

description: Ushu maqolada  Xurshid  Do‘stmuhammadning  “Oromkursi” qissasidagi  ramziyliklar  va  ularning  tag  zamiridagi  ma’noning  asl  mazmun-mohiyati  yoritib  berilgan.
title: ADCO, Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Cart. 143 (7 H 7), 153 fol, f. 0092r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0092r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0092r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb137389344
description: Provenance: abbaye de Molesme
description: Provenance: http://www.wikidata.org/entity/Q334044
Direct ink writing of high-performance multi-level interlocked laminate-network titanium matrix composites
Creators: name: Liu, Zhenqiang
name: Gu, Yujia
name: Yang, Hao
name: Wang, Yun
name: Liu, Weili
name: Yu, Chao
name: Li, Ruitao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Physical Sciences not elsewhere classified
Medicine
Molecular Biology

description: In this study, multi-level laminate-network boron nitride nanosheets (BNNSs)/TC4 composite with interlayer interlocking was fabricated using a facile direct ink writing (DIW) technique. In-situ 3D nano-configurations consisting of BNNSs and TiBx nanophases distributed around TC4 matrix particles formed the first-level network structure, while the above composite layers and TC4 layers with interlayer interlocking formed the second-level laminate structure. It exhibits a comparable high tensile strength of around 1203 MPa, compared to composites with a single-network structure, while demonstrating a 20% higher toughness of 55.8 MJ/m3. The interlayer interlocking microstructure interlayer could be responsible for the strength enhancement, which benefits the stress transfer between layers. The improved ductility could be attributed to the crack blocking adduced by the laminate structure and the 3D network in the composite layers.
ENVRI-FAIR WP5 TF1 Catalogue Task Force - overview
Creators: name: Bailo, Daniele
name: Jeffery, Keith G
Publisher: name: Zenodo
Year: 2022
Subjects: fair, metadata, catalogue, envri-fair, eosc, epos

description: The main objective of this document is to describe the activities of ENVRI-FAIR Task Force 1.
 Task Force 1 goal is to agree and implement a metadata catalogue schema and associated management services, with the aim of describing and providing access to assets available from the ENVRI RIs. This can be potentially used as ENVRI- EOSC catalogue, after appropriate transformation to match EOSC requirements.
Picturing inequities for health impact assessment: linked electronic records, mortality and regional disparities in Portugal
Creators: name: Bacelar-Nicolau, Leonor
name: Rodrigues, Teresa
name: Fernandes, Elisabete
name: Lobo, Mariana F.
name: Nisa, Cláudia Fernandes
name: Azzone, Vanessa
name: Teixeira-Pinto, Armando
name: Altamiro Costa-Pereira
name: Sharon-Lise Teresa Normand
name: Miguel, José Pereira
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Health impact assessment (HIA) focuses on minimizing inequities when studying the effects of a policy on the population’s health. Nevertheless, it is seldom simultaneously quantified, multivariate, and visually graphically comprehensible for non-statisticians. This paper aims to address that gap, assessing a policy promoting the quality of Electronic Health Records, linking hospital and primary health care data (Blood Pressure, Cholesterol, Triglycerides, Waist Circumference, Body Mass Index) to mortality outcomes and regional inequities. Acute Myocardial Infarction patients admitted in the hospital are then followed regularly in Portuguese NHS Primary Care. Regional disparities regarding recorded information are observed and different association patterns with mortality identified, ranked, and visualized through adjusted ORs for sex, age, and indicators of severity of hospital admission, complemented with multivariate correspondence analysis. A pathway to handling equity within quantitative HIA shows that complexity in data and methods may generate simplicity and clarity through visual graphical aids. Tackling Big Data with Data Science in HIA may even be at the center of future health reforms, assessing impacts of health promotion and chronic disease policies.
Entropy-based convergence rates of greedy algorithms
Creators: name: Li, Yuwen
name: Siegel, Jonathan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 41A25, 41A46, 41A65, 65M12, 65N15

description: We present convergence estimates of two types of greedy algorithms in terms of the metric entropy of underlying compact sets. In the first part, we measure the error of a standard greedy reduced basis method for parametric PDEs by the metric entropy of the solution manifold in Banach spaces. This contrasts with the classical analysis based on the Kolmogorov n-widths and enables us to obtain direct comparisons between the greedy algorithm error and the entropy numbers, where the multiplicative constants are explicit and simple. The entropy-based convergence estimate is sharp and improves upon the classical width-based analysis of reduced basis methods for elliptic model problems. In the second part, we derive a novel and simple convergence analysis of the classical orthogonal greedy algorithm for nonlinear dictionary approximation using the metric entropy of the symmetric convex hull of the dictionary. This also improves upon existing results by giving a direct comparison between the algorithm error and the metric entropy.
description: fixed two typos in the older version
Identification and α-glucosidase inhibitory activity evaluation of two new coumarins derived from Mansonia gagei J. R. Drumm.
Creators: name: Le, Huong Thi Thu
name: Hioki, Yusuke
name: Nguyen, Duy Vu
name: Le, Thi-Kim-Dung
name: Nguyen, Van-Kieu
name: Dang, Tien T.
name: Nguyen, Thi-Anh-Tuyet
name: Nguyen, Thi-Hoai-Thu
name: Vu, Thi-Hai-Duyen
name: Pham, Thi-Kim-Ngan
name: Kita, Masaki
name: Chavasiri, Warinthorn
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Virology

description: Five coumarins were isolated from the heartwood of Mansonia gagei, which included two newly discovered compounds, namely 11-hydroxypopulene E (1) and mansorin D (2), along with three previously identified compounds. The structures were determined through the utilisation of comprehensive spectroscopic data, ECD calculations, and a thorough comparison with existing literature data. The α-glucosidase inhibitory activities of all isolated compounds were assessed in yeast. Out of the compounds tested, compound 2 exhibited the most significant activity, displaying a percentage inhibition of 34.33% at a concentration of 200 μM.
Cash Transfers Enable Households to Cope with Agricultural Production and Price Shocks: Evidence from Zambia
Creators: name: Lawlor, Kathleen
name: Sudhanshu Handa
name: Seidenfeld, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Climate change is projected to dramatically disrupt rainfall patterns and agricultural yields in sub-Saharan Africa. These shocks to food production can mire farming households in poverty traps. This study investigates whether unconditional cash transfers can help households cope with agricultural production and price shocks. We find that cash empowers poor, rural households facing these negative shocks to employ coping strategies typically used by the non-poor and enables them to substantially increase their food consumption and overall food security. Extending relatively small cash payments unconditionally to the rural poor is a powerful policy option for fostering climate-resilient development.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0201r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0201r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0201r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Description of the non-Markovian dynamics of atoms in terms of a pure state
Creators: name: Ozhigov, Yuri
name: Jiangchuan, You
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The quantum master equation (QME), used to describe the Markov process of interaction between atoms and field, has a number of significant drawbacks. It is extremely memory intensive, and also inapplicable to the case of long-term memory in the environment. An iterative algorithm for modeling the dynamics of an atomic system in the extended Tavis-Cummings model in terms of a pure state is proposed. The correctness of this algorithm is shown on the example of the interaction of an atomic system with the environment through the exchange of photons with the preservation of coherence. This algorithm is applicable to a wide class of processes associated with photonic machinery, in particular, to chemical reactions.
description: 13 pages, 5 figures, 1 table
Additional file 2 of Non-vitamin K antagonist oral anticoagulants in venous thromboembolism patients: a meta-analysis of real-world studies
Creators: name: Liu, Zhi-Yan
name: Zhang, Han-Xu
name: Ma, Ling-Yue
name: Mu, Guang-Yan
name: Xie, Qiu-Fen
name: Zhou, Shuang
name: Wang, Zi-Ning
name: Wang, Zhe
name: Hu, Kun
name: Xiang, Qian
name: Cui, Yi-Min
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Cancer
Science Policy
Mental Health

description: Additional file 2. Definition of clinical outcomes in the study.