cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: PKP is now a DataCite Registered Service Provider
Creators: name: Bokan, Božana
name: Racy, Famira
name: Stathis, Kelly
Publisher: name: DataCite
Year: 2023

description: The Public Knowledge Project (PKP) and DataCite are pleased to announce that PKP is now a DataCite Registered Service Provider.

The PKP collaborates with scholarly publishing and infrastructure communities to develop and maintain Open Journal Systems (OJS), Open Monograph Press (OMP), and Open Preprint Systems (OPS) publishing software.

As a DataCite Registered Service Provider, PKP’s OJS software integrates with the DataCite MDS API allowing for DataCite Members and Consortium Organizations to register DOIs using their DataCite credentials.

In order to gain this recognition, PKP software had to meet requirements and follow best practices meant to ensure that integrations register DOIs accurately with rich metadata. This post shows examples of the integration and functionality.
Self-association of a synthetic peptide from the N terminus of the hepatitis delta virus protein into an immunoreactive alpha-helical multimer.
Creators: name: Lemon, S. M.
name: Wagner, D. S.
name: Wang, J. G.
name: Erickson, B. W.
name: Rozzelle, J. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The formation of hepatitis delta antigen (HDAg) multimers is required for full biologic activity of this protein and for replication of the hepatitis delta virus. To determine the residues responsible for multimerization, three peptides [ delta 12-49, delta 25-60(Y), delta 12-60(Y)] from the putative coiled-coil multimer-forming domain of HDAg were chemically synthesized and biophysically characterized by circular dichroic spectroscopy, deuterium-exchange mass spectrometry, gel filtration, chemical crosslinking, and ultracentrifugation. By circular dichroism the 50-residue peptide delta 12-60(Y) was half-denatured above 80 degrees C and was 97% alpha-helical at 5 degrees C and 84% alpha-helical at 37 degrees C. By deuterium exchange, peptide delta 12-60(Y) was 93% alpha-helical at 25 degrees C. Its high alpha-helicity and melting temperature are due to the formation of an alpha-helical multimer consisting of four or more chains. All three synthetic peptides reacted with human anti-HDAg antibodies in an enzyme-linked immunosorbent assay, but only peptide delta 12-60(Y) was detected in a sandwich radioimmunoassay in which successful antigens must display at least two antibody-binding sites, which correlates with the ability of this peptide to form multimers. Peptide delta 12-60(Y) also interfered with the self-association of natural HDAg into multimers. These results have significant practical implications for development of improved diagnostic tests, antiviral agents, and possibly even vaccines for prevention of hepatitis delta virus disease.
Serotonin regulates mouse cranial neural crest migration.
Creators: name: Moiseiwitsch, J. R.
name: Lauder, J. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Serotonergic agents (uptake inhibitors, receptor ligands) cause significant craniofacial malformations in cultured mouse embryos suggesting that 5-hydroxytryptamine (serotonin) (5-HT) may be an important regulator of craniofacial development. To determine whether serotonergic regulation of cell migration might underly some of these effects, cranial neural crest (NC) explants from embryonic day 9 (E9) (plug day = E1) mouse embryos or dissociated mandibular mesenchyme cells (derived from NC) from E12 embryos were placed in a modified Boyden chamber to measure effects of serotonergic agents on cell migration. A dose-dependent effect of 5-HT on the migration of highly motile cranial NC cells was demonstrated, such that low concentrations of 5-HT stimulated migration, whereas this effect was progressively lost as the dose of 5-HT was increased. In contrast, most concentrations of 5-HT inhibited migration of less motile, mandibular mesenchyme cells. To investigate the possible involvement of specific 5-HT receptors in the stimulation of NC migration, several 5-HT subtype-selective antagonists were used to block the effects of the most stimulatory dose of 5-HT (0.01 microM). Only NAN-190 (a 5-HT1A antagonist) inhibited the effect of 5-HT, suggesting involvement of this receptor. Further evidence was obtained by using immunohistochemistry with 5-HT receptor antibodies, which revealed expression of the 5-HT1A receptor but not other subtypes by migrating NC cells in both embryos and cranial NC explants. These results suggest that by activating appropriate receptors 5-HT may regulate migration of cranial NC cells and their mesenchymal derivatives in the mouse embryo.
title: Minimax and entropic proximal policy optimization
Creators: name: Song, Yunlong
Publisher: name: UNSPECIFIED
Year: 2023

description: First-order gradient descent is to date the most commonly used optimization method for training deep neural networks, especially for networks with shared parameters, or recurrent neural networks (RNNs). Policy gradient methods provide several advantages over other reinforcement learning algorithms; for example, they can naturally handle continuous state and action spaces. In this thesis, we contribute two different policy gradient algorithms that are straightforward to implement and effective for solving challenging environments, both methods being compatible with large nonlinear function approximations and optimized using stochastic gradient descent. First, we propose a new family of policy gradient algorithms, which we call minimax entropic policy optimization (MMPO). The new method combines the trust region policy optimization and the idea of minimax training, in which stable policy improvement is achieved by formulating the KL-divergence constraint in the trust region policy optimization (TRPO) as a loss function with a ramp function transformation, and then, carrying out a minimax optimization between two stochastic gradient optimizers, one optimizing the "surrogate" objective and another maximizing the ramp-transformed KL-divergence loss function. Our experiments on several challenging continuous control tasks demonstrate that MMPO method achieves comparable performance as TRPO and proximal policy optimization (PPO), however, is much easier to implement compared to TRPO and guarantees that the KL-divergence bound to be satisfied. Second, we investigate the use of the f-divergence as a regularization to the policy improvement, where the f-divergence is a general class of functional measuring the divergence between two probability distributions with the KL-divergence being a special case. The f-divergence can be either treated as a hard constraint or added as a soft constraint to the objective. We propose to treat the f-divergence as a soft constraint by penalizing the policy update step via a penalty term on the f-divergence between successive policy distributions. We term such an unconstrained policy optimization method as f-divergence penalized policy optimization (f-PPO). We focus on a one-parameter family of α-divergences, a special case of f-divergences, and study influences of the choice of divergence functions on policy optimization. The empirical results on a series of MuJoCo environments show that f-PPO with a proper choice of α-divergence is effective for solving challenging continuous control tasks, where α-divergences act differently on the policy entropy, and hence, on the policy improvement.
Buenas prácticas en el uso de las redes sociales
Creators: name: BIREME/OPS/OMS
Publisher: name: Zenodo
Year: 2022
Subjects: Buenas prácticas; LILACS; redes sociales

description: XV Reunión - Buenas prácticas en el uso de las redes sociales Compartiendo Experiencia:
 Lucas Boni Maróstica, Periodista y Consultor de Comunicación en BIREME 28/Septiembre
description: {"references": ["https://red.bvsalud.org/es/fortalecimiento-de-las-redes-de-informacion-en-salud-en-alc/reuniones-de-coordinacion-bvs-y-lilacs/"]}
A magic state's fidelity can be superior to the operations that created it
Creators: name: Li, Ying
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The leading approach to fault tolerant quantum computing requires a continual supply of magic states. When a new magic state is first encoded, its initial fidelity will be too poor for use in the computation. This necessitates a resource-intensive distillation process that occupies the majority of the computer's hardware; creating magic states with a high initial fidelity minimises this cost and is therefore crucial for practical quantum computing. Here we present the surprising and encouraging result that raw magic states can have a fidelity significantly better than that of the two-qubit gate operations used to construct them. Our protocol exploits post-selection without significantly slowing the rate of generation and tolerates finite error rates in initialisations, measurements and single-qubit gates. This approach may dramatically reduce the size of the hardware needed for a given quantum computing task.
description: 5 pages, 4 figures
Whoretography – The Sex Worker As Image-Maker: A critical analysis of sex workers’ self-representation in online public spaces
Creators: name: Waring, Camille
Publisher: name: University of Westminster
Year: 2023

description: There has been an enduring cultural fascination and repulsion with portraits of women sex workers. The sex worker’s role as image-sitter is assumed in the public imagination and remains a steadfast part of contemporary popular culture. However, the ways in which sex workers photograph themselves remain largely unknown. The sex worker is considered an image-sitter who is never viewed in her capacity as a 21st-century image-maker. Hence, the nature of the woman sex worker self-portrait is severely under-researched. This thesis adds to arts-based research approaches that view the self-portraits of marginalised women through an intersectional feminist and self-image framework. This thesis attempts to merge writings on representational discourses and the visual culture of sex work, relocating questions about the sex worker as image-maker to politically oppositional aesthetics of resistance and feminist self-image discourses on representation. The body of work selected for analysis adds to the literature through exploring this overarching thesis: the self-portrait of the sex worker is an artefact that has complex intersecting ideologies with multiple layers of meaning, narratives, and invisibilities, and furthermore, it is a nuanced complex object. As the principal methods of data collection, this research conducted 32 qualitative interviews and a stylistic analysis of the various types of self-portraits extracted from 450 sex workers on the social media platforms Twitter and Instagram. The findings leveraged the theories of several feminist scholars and presented an episteme of the sex worker’s self-portrait, which can be summarised in the following five key points: aesthetics and hierarchy; language and visual literacy; meanings and influences; identity-related, economic, and political contexts; and the consequences of the sex worker self-portrait.
Central Production of Eta and Eta-prime via Double Pomeron Exchange in the Sakai-Sugimoto Model
Creators: name: Anderson, Neil
name: Domokos, Sophia K.
name: Harvey, Jeffrey A.
name: Mann, Nelia
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct a string-inspired model for the central production of $η$ and $η'$ mesons in proton-proton collisions, via double Pomeron exchange. Using general symmetry considerations, we construct a low-energy differential cross section for double glueball exchange in terms of some undetermined coupling constants and form factors. We extend this model to the Regge regime, replacing the glueball propagators with Pomeron trajectories, and modifying the interaction term by a factor derived from the 5-string scattering amplitude in flat space. We then fix the couplings which remain undetermined, using the Sakai-Sugimoto framework to model low-energy QCD. Finally, we generate a simulation of the scattering process at $\sqrt{s} = 29.1 GeV$, where double Pomeron exchange should play a role (secondary to double Reggeon exchange). We focus on the dependence of the scattering cross section on the angle between the scattered protons in the transverse plane. The results exhibit a definite deviation from the angular dependence that arises as a consequence of natural parity violation alone. The amount of deviation is primarily determined by couplings that come from the Chern-Simons action of the AdS/QCD supergravity dual, which is directly related to the QCD gravitational anomaly, and thus constitutes a universal part of any five-dimensional string/gravity dual theory of QCD. We argue that this makes the high energy central production of pseudoscalar mesons an interesting probe of AdS/QCD models.
description: 26 pages, 6 figures
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.
Creators: name: Zhong, W.
name: Keng, T.
name: Fortin, N.
name: Vo, D. T.
name: Clark, M. W.
name: Barton, A. B.
name: Ouellette, B. F.
name: Hall, J.
name: Bussey, H.
name: Kaback, D. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Chromosome I from the yeast Saccharomyces cerevisiae contains a DNA molecule of approximately 231 kbp and is the smallest naturally occurring functional eukaryotic nuclear chromosome so far characterized. The nucleotide sequence of this chromosome has been determined as part of an international collaboration to sequence the entire yeast genome. The chromosome contains 89 open reading frames and 4 tRNA genes. The central 165 kbp of the chromosome resembles other large sequenced regions of the yeast genome in both its high density and distribution of genes. In contrast, the remaining sequences flanking this DNA that comprise the two ends of the chromosome and make up more than 25% of the DNA molecule have a much lower gene density, are largely not transcribed, contain no genes essential for vegetative growth, and contain several apparent pseudogenes and a 15-kbp redundant sequence. These terminally repetitive regions consist of a telomeric repeat called W', flanked by DNA closely related to the yeast FLO1 gene. The low gene density, presence of pseudogenes, and lack of expression are consistent with the idea that these terminal regions represent the yeast equivalent of heterochromatin. The occurrence of such a high proportion of DNA with so little information suggests that its presence gives this chromosome the critical length required for proper function.
The hybrid CONe WD + He star scenario for the progenitors of type Ia supernovae
Creators: name: Wang, Bo
name: Meng, Xiangcun
name: Liu, Dongdong
name: Liu, Zhengwei
name: Han, Zhanwen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The hybrid CONe white dwarfs (WDs) have been suggested to be possible progenitors of type Ia supernovae (SNe Ia). In this article, we systematically studied the hybrid CONe WD + He star scenario for the progenitors of SNe Ia, in which a hybrid CONe WD increases its mass to the Chandrasekhar mass limit by accreting He-rich material from a non-degenerate He star. According to a series of detailed binary population synthesis simulations, we obtained the SN Ia birthrates and delay times for this scenario. The SN Ia birthrates for this scenario are ~0.033-0.539*10^(-3)yr^(-1), which roughly accounts for 1-18% of all SNe Ia. The estimated delay times are ~28Myr-178Myr, which are the youngest SNe Ia predicted by any progenitor model so far. We suggest that SNe Ia from this scenario may provide an alternative explanation of type Iax SNe. We also presented some properties of the donors at the point when the WDs reach the Chandrasekhar mass. These properties may be a good starting point for investigating the surviving companions of SNe Ia, and for constraining the progenitor scenario studied in this work.
description: Accepted for publication in ApJ Letters, 4 figures, 1 table
Landkonflikte - Landutopien
Creators: name: Wacker, Marie-Theres
name: Wainwright, Elaine Mary
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 43 Nr. 2 (2007): Concilium: Internationale Zeitschrift für Theologie, Band 43, Heft 2
Thermodynamic parameters for the helix-coil transition of oligopeptides: molecular dynamics simulation with the peptide growth method.
Creators: name: Wang, L.
name: Tropsha, A.
name: O'Connell, T.
name: Hermans, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The helix-coil transition equilibrium of polypeptides in aqueous solution was studied by molecular dynamics simulation. The peptide growth simulation method was introduced to generate dynamic models of polypeptide chains in a statistical (random) coil or an alpha-helical conformation. The key element of this method is to build up a polypeptide chain during the course of a molecular transformation simulation, successively adding whole amino acid residues to the chain in a predefined conformation state (e.g., alpha-helical or statistical coil). Thus, oligopeptides of the same length and composition, but having different conformations, can be incrementally grown from a common precursor, and their relative conformational free energies can be calculated as the difference between the free energies for growing the individual peptides. This affords a straightforward calculation of the Zimm-Bragg sigma and s parameters for helix initiation and helix growth. The calculated sigma and s parameters for the polyalanine alpha-helix are in reasonable agreement with the experimental measurements. The peptide growth simulation method is an effective way to study quantitatively the thermodynamics of local protein folding.
title: WLI, XPS and SEM/FIB/EDS Surface Characterization of an Electrically Fluted Bearing Raceway
Creators: name: Safdarzadeh, Omid
name: Farahi, Alireza
name: Binder, Andreas
name: Sezen, Hikmet
name: Hofmann, Jan Philipp
Publisher: name: MDPI
Year: 2024

description: Electrical bearing currents may disturb the performance of the bearings via electro-corrosion if they surpass a limit of ca. 0.1 to 0.3 A/mm². A continuous current flow, or, after a longer time span, an alternating current or a repeating impulse-like current, damages the raceway surface, leading in many cases to a fluting pattern on the raceway. Increased bearing vibration, audible noise, and decreased bearing lubrication as a result may demand a replacement of the bearings. Here, an electrically corroded axial ball bearing (type 51208) with fluting patterns is investigated. The bearing was lubricated with grease lubrication and was exposed to 4 A DC current flow. It is shown that the electric current flow causes higher concentrations of iron oxides and iron carbides on the bearing raceway surface together with increased surface roughness, leading to a mixed lubrication also at elevated bearing speeds up to 1500 rpm. The “electrically insulating” iron oxide layer and the “mechanically hard” iron carbide layer on the bearing steel are analysed by WLI, XPS, SEM, and EDS. White Light Interferometry (WLI) is used to provide an accurate measurement of the surface topography and roughness. X-ray Photoelectron Spectroscopy (XPS) measurements are conducted to analyze the chemical surface composition and oxidation states. Scanning Electron Microscopy (SEM) is applied for high-resolution imaging of the surface morphology, while the Focused Ion Beam (FIB) is used to cut a trench into the bearing surface to inspect the surface layers. With the Energy Dispersive X-ray spectrometry (EDS), the presence of composing elements is identified, determining their relative concentrations. The electrically-caused iron oxide and iron carbide may develop periodically along the raceway due to the perpendicular vibrations of the rolling ball on the raceway, leading gradually to the fluting pattern. Still, a simulation of this vibration-induced fluting-generation process from the start with the first surface craters — of the molten local contact spots — to the final fluting pattern is missing.
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.
Creators: name: Li, Y.
name: Datto, M. B.
name: Panus, J. F.
name: Xiong, Y.
name: Howe, D. J.
name: Wang, X. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The transforming growth factor beta s (TGF-beta s) are a group of multifunctional growth factors which inhibit cell cycle progression in many cell types. The TGF-beta-induced cell cycle arrest has been partially attributed to the regulatory effects of TGF-beta on both the levels and the activities of the G1 cyclins and their kinase partners. The activities of these kinases are negatively regulated by a number of small proteins, p21 (WAF1, Cip1), p27Kip1, p16, and p15INK4B, that physically associate with cyclins, cyclin-dependent kinases, or cyclin-Cdk complexes. p21 has been previously shown to be transcriptionally induced by DNA damage through p53 as a mediator. We demonstrate that TGF-beta also causes a rapid transcriptional induction of p21, suggesting that p21 can respond to both intracellular and extracellular signals for cell cycle arrest. In contrast to DNA damage, however, induction of p21 by TGF-beta is not dependent on wild-type p53. The cell line studied in these experiments, HaCaT, contains two mutant alleles of p53, which are unable to activate transcription from the p21 promoter when overexpressed. In addition, TGF-beta and p53 act through distinct elements in the p21 promoter. Taken together, these findings suggest that TGF-beta can induce p21 through a p53-independent pathway. Previous findings have implicated p27Kip1 and p15INK2B as effectors mediating the TGF-beta growth inhibitory effect. These results demonstrate that a single extracellular antiproliferative signal, TGF-beta, can act through multiple signaling pathways to elicit a growth arrest response.
A complexity approach to the soliton resolution conjecture
Creators: name: Bonanno, Claudio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The soliton resolution conjecture is one of the most interesting open problems in the theory of nonlinear dispersive equations. Roughly speaking it asserts that a solution with generic initial condition converges to a finite number of solitons plus a radiative term. In this paper we use the complexity of a finite object, a notion introduced in Algorithmic Information Theory, to show that the soliton resolution conjecture is equivalent to the analogous of the second law of thermodynamics for the complexity of a solution of a dispersive equation.
description: comments are welcome
Additional file 1 of Multilayer factors associated with excess all-cause mortality during the omicron and non-omicron waves of the COVID-19 pandemic: time series analysis in 29 countries
Creators: name: Zou, Fengjuan
name: Xiao, Jianpeng
name: Jin, Yingying
name: Jian, Ronghua
name: Hu, Yijun
name: Liang, Xiaofeng
name: Ma, Wenjun
name: Zhu, Sui
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Measurement of azimuthal correlations between D mesons and charged hadrons with ALICE at the LHC
Creators: name: Colamaria, Fabio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The comparison of angular correlations between charmed mesons and charged hadrons produced in pp, p-Pb and Pb-Pb collisions can give insight into the mechanisms through which charm quarks lose energy in a QGP medium, produced in ultra-relativistic heavy-ion collisions, and can help to recognize possible modifications of their hadronization induced by the presence of the QGP. The analysis of pp and p-Pb data and the comparison with predictions from pQCD calculations, besides constituting the necessary reference for interpreting Pb-Pb data, can provide relevant information on charm production and fragmentation processes. In addition, possible differences between the results from pp and p-Pb collisions can give information on the presence of cold nuclear matter effects, affecting the charm production and hadronization in the latter collision system. A study of azimuthal correlations between D$^0$, D$^+$, and D$^{*+}$ mesons and charged hadrons in pp collisions at $\sqrt{s}$ = 7 TeV and p-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV are presented. D mesons were reconstructed from their hadronic decays at central rapidity in the transverse-momentum range $3 \leq p_{\rm T}^{\rm D} \leq 16$ GeV/$c$ and were correlated to charged particles reconstructed in the pseudorapidity range $|η| < 0.8$. Perspectives for the measurement in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV will also be presented.
description: 5 pages, 4 figures, Proceedings of the QCD@Work 2014 conference, 16-19 June 2014, Giovinazzo (Italy)
Improving North Carolina Law Enforcement Access to and Utilization of Health and Wellness Programs: A Mixed-Methods Evaluation of NC DPS Integrated Behavioral Health Services
Creators: name: Hofer, Meret S.
name: Hofer, Meret
name: Zollie Saxon
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Industrial and Organizational Psychology
subject: Health Psychology
subject: Public Health
subject: Medicine and Health Sciences
subject: Public Affairs, Public Policy and Public Administration
subject: Health Policy
subject: Community Psychology
subject: Health Services Administration
subject: Community Health and Preventive Medicine
subject: Mental and Social Health
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Health Services Research

description: North Carolina Department of Public Safety’s (DPS) Responder Assistance Initiative (NCRAI), formerly the Integrated Behavioral Health Services (IBHS), is a comprehensive suite of programming aimed to provide mental health and wellness services to NC state law enforcement. RTI’s evaluation of NCRAI focuses on examining the impact of the NCRAI program on behavioral health service utilization by state law enforcement officers in North Carolina. RTI International is an independent non-profit organization dedicated to improving the human condition. The researchers involved in this evaluation work within the Justice Practice Area within RTI International and are part of the policing research group. The goals of our evaluation are guided by critical questions related to the imminent expansion of the NCRAI program to local law enforcement agencies and other first responder populations across North Carolina, such as how to optimize the value of the array of NCRAI services and address disparities in service utilization.
title: Design and FPGA implementation of a highly resource-efficient AES-256 encryption and decryption engine
Creators: name: García Rodríguez, Saul
Publisher: name: Fachhochschule Dortmund
Year: 2023
Subjects: subject: 004 Informatik

description: Growing demand for security in a wide range of fields gives raise to research for more efficient and modern methods. Additionally, the increase of systems that are deployed on hardware requires security to be embedded in small area to protect intellectual property, hardware, and integrity and confidentially of sensible data. Therefore, in this work a design and FPGA implementation of a highly resource-efficient AES-256 encryption and decryption engine is presented, as well as its comparison with state-of-the-art designs. The design shows a reduction in the resources used due to its architecture to reuse hardware throughout all the processing. The design is implemented on a Xilinx Artix-7 FPGA.
Appendix to IFAMR2022.0111
Creators: name: Yang, Yang
name: Hobbs, Jill E.
name: Natcher, David C.
Publisher: name: Brill Online
Year: 2023
Subjects: classificationCode: 300204
subject: Agricultural management of nutrients

description: Materials and methods S1. One-step vs three-step latent class analysis.Materials and methods S2. Food values’ scale of importance.Materials and methods S3. Model selection and parameter estimates for latent class analysis.Figure S1. Importance of food issues.Table S1. Summary of survey respondents’ food values (n=1602).Table S2. Summary statistics for model selection.Table S3. Parameter estimates for latent class analysis (n=1602).
Measuring and manipulating the temperature of cold molecules trapped on a chip
Creators: name: Marx, Silvio
name: Smith, David Adu
name: Sartakov, Boris G.
name: Meijer, Gerard
name: Santambrogio, Gabriele
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We demonstrate the measurement and manipulation of the temperature of cold CO molecules in a microchip environment. Through the use of time-resolved spatial imaging, we are able to observe the phase-space distribution of the molecules, and hence deduce the corresponding temperature. We do this both by observing the expansion of the molecular ensemble in time and through the use of numerical trajectory simulations. Furthermore, we demonstrate the adiabatic cooling of the trapped molecular sample and discuss this process.
description: 6 pages, 4 figures
Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.
Creators: name: Gangarosa, L. M.
name: Clark, G. J.
name: Der, C. J.
name: Coffey, R. J.
name: Oldham, S. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The potent transforming activity of membrane-targeted Raf-1 (Raf-CAAX) suggests that Ras transformation is triggered primarily by a Ras-mediated translocation of Raf-1 to the plasma membrane. However, whereas constitutively activated mutants of Ras [H-Ras(61L) and K-Ras4B(12V)] and Raf-1 (DeltaRaf-22W and Raf-CAAX) caused indistinguishable morphologic and growth (in soft agar and nude mice) transformation of NIH 3T3 fibroblasts, only mutant Ras caused morphologic transformation of RIE-1 rat intestinal cells. Furthermore, only mutant Ras-expressing RIE-1 cells formed colonies in soft agar and developed rapid and progressive tumors in nude mice. We also observed that activated Ras, but not Raf-1, caused transformation of IEC-6 rat intestinal and MCF-10A human mammary epithelial cells. Although both Ras- and DeltaRaf-22W-expressing RIE-1 cells showed elevated Raf-1 and mitogen-activated protein (MAP) kinase activities, only Ras-transformed cells produced secreted factors that promoted RIE-1 transformation. Incubation of untransformed RIE-1 cells in the presence of conditioned medium from Ras-expressing, but not DeltaRaf-22W-expressing, cells caused a rapid and stable morphologic transformation that was indistinguishable from the morphology of Ras-transformed RIE-1 cells. Thus, induction of an autocrine growth mechanism may distinguish the transforming actions of Ras and Raf. In summary, our observations demonstrate that oncogenic Ras activation of the Raf/MAP kinase pathway alone is not sufficient for full tumorigenic transformation of RIE-1 epithelial cells. Thus, Raf-independent signaling events are essential for oncogenic Ras transformation of epithelial cells, but not fibroblasts.
Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.
Creators: name: Datta, M.
name: Spychala, J.
name: Gribbin, T.
name: Datta, N. S.
name: Fox, I. H.
name: Takabayashi, K.
name: Mitchell, B. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Adenosine kinase catalyzes the phosphorylation of adenosine to AMP and hence is a potentially important regulator of extracellular adenosine concentrations. Despite extensive characterization of the kinetic properties of the enzyme, its primary structure has never been elucidated. Full-length cDNA clones encoding catalytically active adenosine kinase were obtained from lymphocyte, placental, and liver cDNA libraries. Corresponding mRNA species of 1.3 and 1.8 kb were noted on Northern blots of all tissues examined and were attributable to alternative polyadenylylation sites at the 3' end of the gene. The encoding protein consists of 345 amino acids with a calculated molecular size of 38.7 kDa and does not contain any sequence similarities to other well-characterized mammalian nucleoside kinases, setting it apart from this family of structurally and functionally related proteins. In contrast, two regions were identified with significant sequence identity to microbial ribokinase and fructokinases and a bacterial inosine/guanosine kinase. Thus, adenosine kinase is a structurally distinct mammalian nucleoside kinase that appears to be akin to sugar kinases of microbial origin.
Appendix to IFAMR2022.0111
Creators: name: Yang, Yang
name: Hobbs, Jill E.
name: Natcher, David C.
Publisher: name: Brill Online
Year: 2023
Subjects: classificationCode: 300204
subject: Agricultural management of nutrients

description: Materials and methods S1. One-step vs three-step latent class analysis.Materials and methods S2. Food values’ scale of importance.Materials and methods S3. Model selection and parameter estimates for latent class analysis.Figure S1. Importance of food issues.Table S1. Summary of survey respondents’ food values (n=1602).Table S2. Summary statistics for model selection.Table S3. Parameter estimates for latent class analysis (n=1602).
Development and characterization of a rodent model of immune-mediated cholangitis.
Creators: name: Ludwig, J.
name: LaRusso, N. F.
name: Lichtman, S. N.
name: Ueno, Y.
name: Phillips, J. O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The cholangiopathies are a group of hepatobiliary diseases in which intrahepatic bile duct epithelial cells, or cholangiocytes, are the target for a variety of destructive processes, including immune-mediated damage. We tested the hypothesis that cholangitis could be induced in rodents by immunization with highly purified cholangiocytes. Inbred Wistar rats were immunized with purified hyperplastic cholangiocytes isolated after bile duct ligation from either syngeneic Wistar or allogeneic Fischer 344 rats; control rats were immunized with bovine serum albumin (BSA) or hepatocytes. After immunization with cholangiocytes, recipient animals developed histologic evidence of nonsuppurative cholangitis without inflammation in other organs; groups immunized with BSA or hepatocytes showed no cholangitis. Immunohistochemical studies revealed that portal tract infiltrates around bile ducts consisted of CD3-positive lymphocytes, some of which expressed major histocompatibility complex class II antigen; B cells and exogenous monocytes/macrophages were essentially absent. Transfer of unfractionated ConA-stimulated spleen cells from cholangiocyte-immunized (but not BSA-immunized) rats into recipients also caused nonsuppurative cholangitis. Moreover, these splenocytes from cholangiocyte-immunized (but not BSA-immunized) rats were cytotoxic in vitro for cultured rodent cholangiocytes; no cytotoxicity was observed against a rat hepatocyte cell line. Also, a specific antibody response in sera of cholangiocyte-immunized rats was demonstrated by immunoblots against cholangiocyte proteins. Finally, cholangiograms in cholangiocyte-immunized rats showed distortion and tortuosity of the entire intrahepatic biliary ductal system. This unique rodent model of experimental cholangitis demonstrates the importance of immune mechanisms in the pathogenesis of cholangitis and will prove useful in exploring the mechanisms by which the immune system targets and damages cholangiocytes.
Additional file 1 of Effects of a randomized-controlled and online-supported physical activity intervention on exercise capacity, fatigue and health related quality of life in patients with post-COVID-19 syndrome
Creators: name: Kerling, Arno
name: Beyer, Sebastian
name: Dirks, Meike
name: Scharbau, Michèle
name: Hennemann, Ann-Katrin
name: Dopfer-Jablonka, Alexandra
name: Lampe, Viktoria
name: Salzmann, Jakob Heinrich Wolfgang
name: Tegtbur, Uwe
name: Drick, Nora
name: Pink, Isabell
name: Haufe, Sven
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health

description: Supplementary Material 1
Surface Plasmon Instability Leading to Emission of Radiation
Creators: name: Gumbs, Godfrey
name: Iurov, Andrii
name: Huang, Danhong
name: Pan, Wei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We propose a new energy conversion approach from a dc electric field to a terahertz wave based on hybrid semiconductors by combining two-dimensional (2D) crystalline layers and a thick conducting material with possible applications as a source of coherent radiation. The hybrid nano-structure may consist of a single or pair of sheets of graphene, silicene or a 2D electron gas as would occur at a semiconductor hetero-interface. When an electric current is passed through a layer, we discover that the low-frequency plasmons may become unstable beyond a critical wave vector $q_c$. However, there is no instability for a single driven layer far from the conductor and the instability of an isolated pair of 2D layers occurs only at ultra long wavelengths. To bring in frequency agility for this spontaneous radiation, we manipulate the surface-plasmon induced instability, which leads to the emission of radiation (spiler), to occur at shorter wavelengths by choosing the conductor electron density, layer separation, distances of layers from the conductor surface and the driving-current strength. Applications of terahertz radiation from spiler for chemical analysis, security scanning, medical imaging and telecommunications are expected.
description: 8 pages, 4 figures. arXiv admin note: substantial text overlap with arXiv:1410.2851
Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.
Creators: name: Fowlkes, D. M.
name: Sparks, A. B.
name: Kay, B. K.
name: Hoffman, N. G.
name: Rider, J. E.
name: Quillam, L. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Src homology 3 (SH3) domains are conserved protein modules 50-70 amino acids long found in a variety of proteins with important roles in signal transduction. These domains have been shown to mediate protein-protein interactions by binding short proline-rich regions in ligand proteins. However, the ligand preferences of most SH3 domains and the role of these preferences in regulating SH3-mediated protein-protein interactions remain poorly defined. We have used a phage-displayed library of peptides of the form X6PXXPX6 to identify ligands for eight different SH3 domains. Using this approach, we have determined that each SH3 domain prefers peptide ligands with distinct sequence characteristics. Specifically, we have found that the Src SH3 domain selects peptides sharing the consensus motif LXXRPLPXpsiP, whereas Yes SH3 selects psiXXRPLPXLP, Abl SH3 selects PPXthetaXPPPpsiP, Cortactin SH3 selects +PPpsiPXKPXWL, p53bp2 SH3 selects RPXpsiPpsiR+SXP, PLCgamma SH3 selects PPVPPRPXXTL, Crk N-terminal SH3 selects psiPpsiLPpsiK, and Grb2 N-terminal SH3 selects +thetaDXPLPXLP (where psi, theta, and + represent aliphatic, aromatic, and basic residues, respectively). Furthermore, we have compared the binding of phage expressing peptides related to each consensus motif to a panel of 12 SH3 domains. Results from these experiments support the ligand preferences identified in the peptide library screen and evince the ability of SH3 domains to discern subtle differences in the primary structure of potential ligands. Finally, we have found that most known SH3-binding proteins contain proline-rich regions conforming to the ligand preferences of their respective SH3 targets.
CAA Food Toolkit - Methoden zur Erforschung von Nachhaltigkeit durch Lebensmittelsysteme und Ernährungsgewohnheiten
Creators: name: BluoVerda Deutschland e.V.
name: 2811 Social Enterprise UG
Publisher: name: Zenodo
Year: 2023

description: Dieses Toolkit bietet eine Sammlung von Ressourcen und Werkzeugen, die formellen und informellen Pädagogen helfen, junge Menschen effektiv in Diskussionen über Nachhaltigkeit und Klimawandel einzubeziehen. Durch die Konzentration auf Lebensmittelsysteme und Ernährungsgewohnheiten bietet es einen ansprechenden und nachvollziehbaren Einstieg in das komplexe Thema Klimawandel.
Supplementary document for Homemade open-source full-Stokes polarimeter based on division of amplitude - 7162356.pdf
Creators: name: del Río-Lima, Alejandra
name: Valdés, Andrés Gutiérrez
name: Mojica-Casique, Cristian
name: Ballesteros-Flores, Fernando
name: Villanueva-Reyes, Itze
name: Colín-Rodríguez, Ricardo
name: Gardea-Flores, Carlos
name: Poveda-Cuevas, Jackson
name: Harutinian, Jorge Seman
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplemental information concerning designs, measurements, and comparisons with other similar instruments.
Virtual surface morphology generation of Ti-6Al-4V directed energy deposition via conditional generative adversarial network
Creators: name: Kim, Taekyeong
name: Kim, Jung Gi
name: Park, Sangeun
name: Kim, Hyoung Seop
name: Kim, Namhun
name: Ha, Hyunjong
name: Choi, Seung-Kyum
name: Tucker, Conrad
name: Sung, Hyokyung
name: Jung, Im Doo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: The core challenge in directed energy deposition is to obtain high surface quality through process optimisation, which directly affects the mechanical properties of fabricated parts. However, for expensive materials like Ti-6Al-4V, the cost and time required to optimise process parameters can be excessive in inducing good surface quality. To mitigate these challenges, we propose a novel method with artificial intelligence to generate virtual surface morphology of Ti-6Al-4V parts by given process parameters. A high-resolution surface morphology image generation system has been developed by optimising conditional generative adversarial networks. The developed virtual surface matches experimental cases well with an Fréchet inception distance score of 174, in the range of accurate matching. Microstructural analysis with parts fabricated with artificial intelligence guidance exhibited less textured microstructural behaviour on the surface which reduces the anisotropy in the columnar structure. This artificial intelligence guidance of virtual surface morphology can help to obtain high-quality parts cost-effectively.
Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.
Creators: name: Dannals, R. F.
name: Marenco, S.
name: Ravert, H. T.
name: Bryan, R. N.
name: Yaster, M.
name: Naidu, S.
name: Wong, D. F.
name: Rousset, O.
name: Evans, A.
name: Breese, G. R.
name: Gjedde, A.
name: Kuhar, M. J.
name: Harris, J. C.
name: Yokoi, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Dopamine (DA) deficiency has been implicated in Lesch-Nyhan disease (LND), a genetic disorder that is characterized by hyperuricemia, choreoathetosis, dystonia, and compulsive self-injury. To establish that DA deficiency is present in LND, the ligand WIN-35,428, which binds to DA transporters, was used to estimate the density of DA-containing neurons in the caudate and putamen of six patients with classic LND. Comparisons were made with 10 control subjects and 3 patients with Rett syndrome. Three methods were used to quantify the binding of the DA transporter so that its density could be estimated by a single dynamic positron emission tomography study. These approaches included the caudate- or putamen-to-cerebellum ratio of ligand at 80-90 min postinjection, kinetic analysis of the binding potential [Bmax/(Kd x Vd)] using the assumption of equal partition coefficients in the striatum and the cerebellum, and graphical analysis of the binding potential. Depending on the method of analysis, a 50-63% reduction of the binding to DA transporters in the caudate, and a 64-75% reduction in the putamen of the LND patients was observed compared to the normal control group. When LND patients were compared to Rett syndrome patients, similar reductions were found in the caudate (53-61%) and putamen (67-72%) in LND patients. Transporter binding in Rett syndrome patients was not significantly different from the normal controls. Finally, volumetric magnetic resonance imaging studies detected a 30% reduction in the caudate volume of LND patients. To ensure that a reduction in the caudate volume would not confound the results, a rigorous partial volume correction of the caudate time activity curve was performed. This correction resulted in an even greater decrease in the caudate-cerebellar ratio in LND patients when contrasted to controls. To our knowledge, these findings provide the first in vivo documentation of a dopaminergic reduction in LND and illustrate the role of positron emission tomography imaging in investigating neurodevelopmental disorders.