cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the effector suite profile of Australian Fusarium oxysporum isolates from agricultural and natural ecosystems
Creators: name: Achari, Saidi
name: Kaur, Jatinder
name: Mann, Ross
name: Sawbridge, Tim
name: Summerell, Brett A
name: Edwards, Jacqueline
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3004
subject: Crop and pasture production
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3107
subject: Microbiology
classificationCode: 3108
subject: Plant biology

description: © 2020 The Authors. Plant Pathology published by John Wiley & Sons Ltd on behalf of British Society for Plant Pathology Pathogenic and putatively nonpathogenic isolates of Fusarium oxysporum are ubiquitously present in soils. Pathogenic isolates designated as formae speciales are very host specific. The genes that determine host-specific pathogenicity may be expected to be similar between strains within a forma specialis. Three different pathways were used for mining putative effectors from 85 assembled genome sequences representing isolates from the agricultural and natural ecosystems. A total of 436 putative effectors were identified, of which 115 were present in all the isolates. The presence–absence phylogeny showed some clustering of isolates based on the ecosystems, while some clustered with isolates from different ecosystems. Isolates from the agricultural and natural ecosystems shared 358 putative effectors. Agricultural isolates had 78 unique putative effectors, while isolates from the natural ecosystems had no unique effectors. Isolates from the natural ecosystems had effectors that have previously been confirmed with virulence functions in other filamentous fungi, suggesting that the natural ecosystems may be acting as a reservoir for pathogenic isolates awaiting compatible hosts. They also possessed putative effectors with domains involved in polysaccharide degradation. The putative effectors in the natural ecosystem isolates may be important for both parasitic and ecological fitness. Further analysis of the three characterized ff. sp.—lycopersici, niveum, and pisi—revealed high conservation in the pathogenicity mechanism in F. oxysporum. However, each strain had unique putative effectors, which may be responsible for host specificity.
Additional_File_2 – Supplemental material for The Monetary Value of Disability-Adjusted Life Years in Kenya in 2017
Creators: name: Muthuri, Rose Nabi Deborah Karimi
name: Joses Muthuri Kirigia
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, Additional_File_2 for The Monetary Value of Disability-Adjusted Life Years in Kenya in 2017 by Rose Nabi Deborah Karimi Muthuri and Joses Muthuri Kirigia in SAGE Open
MiR-27b-3p ameliorates DOX-induced cardiotoxicity by suppressing myocardial inflammation and oxidative stress in mice and cardiomyocytes
Creators: name: Gao, Ying
name: Yang, Shujun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Doxorubicin (DOX), a chemotherapeutic drug used for cancer treatment, faces limitations in clinical use due to its cardiotoxicity. The study intended to investigate the effect of microRNA (miR)-27b-3p on DOX-induced cardiotoxicity. Quantitative polymerase chain reaction was conducted to identify the miR-27b-3p expression in cardiac tissues of 24 mice exposure to doxorubicin for 0–7days. To investigate the functions of miR-27b-3p, the remaining 40 mice were assigned into 4 experimental groups (n=10 per group): Control+miR-scramble, Control+miR-27b-3p, chronic heart failure (CHF) + miR-scramble, and CHF+miR-27b-3p. Specifically, C57BL/6J mice received a tail vein injection of adeno-associated viral 9 (AAV9)-miR-27b-3p/miR-scramble and/or intraperitoneal injection of 15mg/kg DOX. Echocardiography was used to measure basic cardiac function parameters. Hematoxylin-eosin and Sirius red staining were performed to assess cardiac structural changes and fibrotic areas. For cellular experiments, neonatal mouse cardiomyocytes were exposure to 5μg/ml DOX. The levels of inflammatory factors and oxidative stress indicators in cardiac tissues or cardiomyocytes were assessed by western blotting, enzyme-linked immunosorbent assay, or corresponding detection kits. The results showed that miR-27b-3p expression was downregulated in mouse cardiac tissues following DOX treatment. Overexpression of miR-27b-3p improved cardiac function and ameliorated pathological changes in mice. In addition, DOX-induced myocardial inflammation and oxidative stress were mitigated by miR-27b-3p overexpression both in vivo and in vitro. MiR-27b-3p negatively regulated the expression of four target genes (Plk2, Adora2b, Apaf1 and Nrk) in DOX-stimulated cardiomyocytes. In conclusion, miR-27b-3p ameliorates DOX-induced cardiac dysfunction and myocardial injury by inhibiting inflammation and oxidative stress.
Supplemental_Material_Magnan_et_al._Revised – Supplemental material for A comparison of Holocene testate amoeba assemblages and paleohydrological records from pollen slides and wet-sieved peat
Creators: name: Magnan, Gabriel
name: Lacourse, Terri
name: Garneau, Michelle
Publisher: name: SAGE Journals
Year: 2020
Subjects: Geography
History

description: Supplemental material, Supplemental_Material_Magnan_et_al._Revised for A comparison of Holocene testate amoeba assemblages and paleohydrological records from pollen slides and wet-sieved peat by Gabriel Magnan, Terri Lacourse and Michelle Garneau in The Holocene
sj-pdf-1-cep-10.1177_0333102420965146 - Supplemental material for Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients
Creators: name: López, Javier Trigo
name: García-Azorín, David
name: Planchuelo-Gómez, Álvaro
name: García-Iglesias, Cristina
name: Dueñas-Gutiérrez, Carlos
name: Guerrero, Ángel L
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-pdf-1-cep-10.1177_0333102420965146 for Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients by Javier Trigo López, David García-Azorín, Álvaro Planchuelo-Gómez, Cristina García-Iglesias, Carlos Dueñas-Gutiérrez and Ángel L Guerrero in Cephalalgia
Museums, Students, Zoology and the Public: Bringing Them All Together
Creators: name: Ashby, Jack
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Museums, Students, Zoology and the Public: Bringing Them All Together by Jack Ashby of University Museum of Zoology, Cambridge Cambridge United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
The effect of cut sizes and pH of tobacco leaf in smokeless tobacco products on the pharmacokinetics of nicotine
Creators: name: Fu, Ya’ning
name: Wang, Hongjuan
name: Li, Yingyan
name: Yu, Pengpeng
name: Su, Yue
name: Ma, Wanwan
name: Han, Shulei
name: Tian, Yushan
name: Chen, Huan
name: Hou, Hongwei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health
subject: Plant Biology

description: The absorption of nicotine from smokeless tobacco products (STPs) in humans is affected by various factors, including nicotine content, flavoring compounds, cutting format, tobacco cut sizes, and pH. In this study, participants were asked to use STP 1 for a specific period, after which the nicotine content was measured before and after use to determine the release rate using the Weibull model. Blood samples were collected from participants after 30 min of using STP 1 to assess nicotine pharmacokinetics. Additionally, guinea pigs were administered four types of STPs with varying pH levels, and tobacco cut sizes, but with identical nicotine content on the oral mucosa to evaluate nicotine pharmacokinetics. The human results showed that nicotine in STP was quickly released in the mouth, reaching 73.66% within 30 min. Plasma nicotine concentration in guinea pigs and human participants were comparable following STP use. Guinea pigs exposed to STPs with smaller tobacco cut sizes or higher pH absorbed more nicotine and metabolized it more slowly. The findings suggest that pH and cut size of STPs are key factors affecting nicotine absorption, while the impact of flavoring agents and other components on nicotine absorption remains to be determined.
Additional file 1 of Fusion plasmid enhanced the endemic extensively drug resistant Klebsiella pneumoniae clone ST147 harbored blaOXA-48 to acquire the hypervirulence and cause fatal infection
Creators: name: Liu, Chao
name: Du, Pengcheng
name: Yang, Ping
name: Lu, Ming
name: Shen, Ning
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. AST of the ST147 clone and its passage. Table S2. Pairwise SNP comparison between ST147 strains in this study. The numbers depict differences in SNPs exhibited by each strain pair. Figure S1. Growth curves of the ST147 strains. Figure S2. Serum killing assays of the ST147 isolates. Figure S3. Virulence of the MDR-ST147-hvKp evaluated by the Galleria mellonella model. Figure S4. Phylogenetic analysis of ST147 Kp in our hospital and the published ST147 genomes from GenBank database. The red dots adjacent to the tips of the tree represent MDR strains, the outer two rings of color bars represent resistance score and virulence score calculated by kleborate software, and the outer blue dots represent hvKp strains based on the presence of the five virulence associated genes including peg-344, iroB, iucA, rmpA, and rmpA2. Figure S5. Comparison between plasmid pPEKP4265-70 encoding blaOXA-48 found in this study and similar plasmids found in the online NCBI database. The outmost circle of arrows indicate the genes of reference plasmid pPEKP4265-70 used for comparison (red: AMR genes; green: integrase, recombinase, and transposase genes; purple: transfer associated genes; orange: gray: other functions). Figure S6. Comparison between plasmid pPEKP4265-152 encoding blaCTX-M-15 found in this study and similar plasmids found in the online NCBI database. The outmost circle of arrows indicate the genes of reference plasmid pPEKP4265-152 used for comparison (red: AMR genes; green: integrase, recombinase, and transposase genes; purple: transfer associated genes; orange: gray: other functions).
priors – Supplemental material for Using informant discrepancies in report of parent–adolescent conflict to predict hopelessness in adolescent depression
Creators: name: Rognli, Erling W
name: Aalberg, Marianne
name: Czajkowski, Nikolai Olavi
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental material, priors for Using informant discrepancies in report of parent–adolescent conflict to predict hopelessness in adolescent depression by Erling W Rognli, Marianne Aalberg and Nikolai Olavi Czajkowski in Clinical Child Psychology and Psychiatry
Investigating the effector suite profile of Australian Fusarium oxysporum isolates from agricultural and natural ecosystems
Creators: name: Achari, Saidi
name: Kaur, Jatinder
name: Mann, Ross C
name: Sawbridge, Tim
name: Summerell, Brett A
name: Edwards, Jacqueline
Publisher: name: La Trobe
Year: 2024

description: © 2020 The Authors. Plant Pathology published by John Wiley & Sons Ltd on behalf of British Society for Plant Pathology Pathogenic and putatively nonpathogenic isolates of Fusarium oxysporum are ubiquitously present in soils. Pathogenic isolates designated as formae speciales are very host specific. The genes that determine host-specific pathogenicity may be expected to be similar between strains within a forma specialis. Three different pathways were used for mining putative effectors from 85 assembled genome sequences representing isolates from the agricultural and natural ecosystems. A total of 436 putative effectors were identified, of which 115 were present in all the isolates. The presence–absence phylogeny showed some clustering of isolates based on the ecosystems, while some clustered with isolates from different ecosystems. Isolates from the agricultural and natural ecosystems shared 358 putative effectors. Agricultural isolates had 78 unique putative effectors, while isolates from the natural ecosystems had no unique effectors. Isolates from the natural ecosystems had effectors that have previously been confirmed with virulence functions in other filamentous fungi, suggesting that the natural ecosystems may be acting as a reservoir for pathogenic isolates awaiting compatible hosts. They also possessed putative effectors with domains involved in polysaccharide degradation. The putative effectors in the natural ecosystem isolates may be important for both parasitic and ecological fitness. Further analysis of the three characterized ff. sp.—lycopersici, niveum, and pisi—revealed high conservation in the pathogenicity mechanism in F. oxysporum. However, each strain had unique putative effectors, which may be responsible for host specificity.
sj-pdf-1-inc-10.1177_1751143720971543 - Supplemental material for Positive role of continuous positive airway pressure for intensive care unit patients with severe hypoxaemic respiratory failure due to COVID-19 pneumonia: A single centre experience
Creators: name: Wozniak, Dariusz R
name: Rubino, Antonio
name: Tan, Aileen LW
name: Jones, Nicola L
name: Webb, Stephen T
name: Vuylsteke, Alain
name: Palas, Earl
name: Quinnell, Timothy G
name: Smith, Ian E
name: Davies, Michael G
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-inc-10.1177_1751143720971543 for Positive role of continuous positive airway pressure for intensive care unit patients with severe hypoxaemic respiratory failure due to COVID-19 pneumonia: A single centre experience by Dariusz R Wozniak, Antonio Rubino, Aileen LW Tan, Nicola L Jones, Stephen T Webb, Alain Vuylsteke, Earl Palas, Timothy G Quinnell, Ian E Smith and Michael G Davies in Journal of the Intensive Care Society
The impact of superstitions on practices with Cururu toads in Brazil
Creators: name: Aranha, Natália
name: Rebouças, Raoni
name: Toledo, Luís Felipe
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Amphibians are generally associated with negative perceptions due to their body characteristics. Among these, Cururu toads from the Rhinella genus are a frequent targets of negative practices. Thus, we gathered information available on internet platforms on the Cururu toad use in cultural manifestations in Brazil. We gathered over 100 records and used this data to calculate the relative and frequency of occurrences between 2007 and 2022. Among the practices, the most frequent was sewing and gluing their mouths shut. Among the states of Brazil, São Paulo and Paraná had the highest frequency of occurrence, while the states of Amapá and Paraná had the highest relative occurrence. We also observed that the Cururu toad use in cultural manifestations remained constant over time and was widespread throughout the country. Based on our findings, we emphasize that environmental education programs should be implemented for the population, aiming to reduce animal abuse in amphibians.
Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies
Creators: name: JSY Lau
name: MZ Smith
name: B Allan
name: C Martinez
name: Power, Jennifer
name: SR Lewin
name: JH McMahon
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2020, The Author(s). Background: Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the acceptability of ATI amongst people living with HIV (PLHIV) and their HIV healthcare providers (HHP) is limited. Methods: Two online surveys for PLHIV and HHP assessed awareness and acceptability of ATI, and understanding of the prospect for HIV cure in the future. Responses were collected from July 2017–January 2018. A descriptive analysis was performed and similar questions across the two surveys were compared using χ squared test. Results: 442 PLHIV and 144 HHP completed the survey. 105/400 (26%) PLHIV had ever interrupted ART, 8% of which were in a clinical trial. Altruistic motivations were drivers of participation of PLHIV in cure related research. 81/135 (60%) HHP would support their patients wishing to enrol in an HIV cure-focused trial, but fewer would promote and allow such participation (25% and 31% respectively). Compared to HHP, PLHIV were more likely to believe that an HIV cure would be achievable within 10 years (55% vs. 19%, p < 0.001), had less awareness of ATI (46% vs. 62%, p < 0.001) and were less likely to have had experience of either participation or enrolment in an ATI study (5% vs. 18%, p < 0.001) Conclusion: PLHIV were more optimistic about the potential for HIV cure. HHP had more direct experience with HIV cure-focused studies. Educational strategies are required for both groups to increase understanding around ATIs in HIV cure research but should be tailored specifically to each group.
Understanding the influence of the head coach on soccer training drills—an 8 season analysis
Creators: name: S Barrett
name: Varley, Matthew
name: SP Hills
name: M Russell
name: M Reeves
name: A Hearn
name: C Towlson
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Soccer players perform a variety of training drills to develop the physical, technical and tactical qualities required for match-play. The role of coaches in prescribing training suggests that players may not always meet physical targets set by conditioning staff. To quantify the physical outputs elicited by different training drill types, 183 professional soccer players were monitored over 8 seasons using Microelectromechanical Systems during normal training, yielding 65,825 drill observations [362 ± 341 observations·player−1]. Linear mixed models assessed the influence of drill type, head coach and playing position on physical output. Drills lasted ~14 min, eliciting total distances and high speed running of ~1000 m and 40 m, respectively. Conditioning drills elicited substantially greater relative high-speed running [18.8 ± 27.2 m.min−1] and Sprint [3.5 ± 9.4 m.min−1] distances than all other drill types. The proportion of training drill types used and external outputs elicited per drill were affected by the head coach. Midfielders recorded the highest total distance [77.3 ± 36.1 m.min] and PlayerLoad™ [8.29 ± 3.54] of any playing position, whilst the lowest outputs were recorded by goalkeepers. This study provides reference data for practitioners when seeking to manipulate training prescription to achieve physical output targets whilst also meeting the team’s technical and tactical objectives.
Cirrhotic portal hypertension: From pathophysiology to novel therapeutics
Creators: name: LS Gunarathne
name: Kolin Rajapaksha
name: N Shackel
name: PW Angus
name: CB Herath
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized by a high cardiac output, increased total blood volume and splanchnic vasodilatation, resulting in increased mesenteric blood flow. Pharmacological manipulation of cirrhotic portal hypertension targets both the splanchnic and hepatic vascular beds. Drugs such as angiotensin converting enzyme inhibitors and angiotensin II type receptor 1 blockers, which target the components of the classical renin angiotensin system (RAS), are expected to reduce intrahepatic vascular tone by reducing extracellular matrix deposition and vasoactivity of contractile cells and thereby improve portal hypertension. However, these drugs have been shown to produce significant off-target effects such as systemic hypotension and renal failure. Therefore, the current pharmacological mainstay in clinical practice to prevent variceal bleeding and improving patient survival by reducing portal pressure is non-selective -blockers (NSBBs). These NSBBs work by reducing cardiac output and splanchnic vasodilatation but most patients do not achieve an optimal therapeutic response and a significant proportion of patients are unable to tolerate these drugs. Although statins, used alone or in combination with NSBBs, have been shown to improve portal pressure and overall mortality in cirrhotic patients, further randomized clinical trials are warranted involving larger patient populations with clear clinical end points. On the other hand, recent findings from studies that have investigated the potential use of the blockers of the components of the alternate RAS provided compelling evidence that could lead to the development of drugs targeting the splanchnic vascular bed to inhibit splanchnic vasodilatation in portal hypertension. This review outlines the mechanisms related to the pathogenesis of portal hypertension and attempts to provide an update on currently available therapeutic approaches in the management of portal hypertension with special emphasis on how the alternate RAS could be manipulated in our search for development of safe, specific and effective novel therapies to treat portal hypertension in cirrhosis.
appendix_1 – Supplemental material for Comparing the effects of no intervention with therapeutic exercise, and exercise with additional Kinesio tape in patients with shoulder impingement syndrome. A three-arm randomized controlled trial
Creators: name: Letafatkar, Amir
name: Pouya Rabiei
name: Sarvenaz Kazempour
name: Samaneh Alaei-Parapari
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, appendix_1 for Comparing the effects of no intervention with therapeutic exercise, and exercise with additional Kinesio tape in patients with shoulder impingement syndrome. A three-arm randomized controlled trial by Amir Letafatkar, Pouya Rabiei, Sarvenaz Kazempour and Samaneh Alaei-Parapari in Clinical Rehabilitation
Musings of a paleontology community of practice at the Museum of Comparative Zoology
Creators: name: Byrd, Christina
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Musings of a paleontology community of practice at the Museum of Comparative Zoology by Curatorial Associate, Vertebrate Paleontology Christina Byrd of Curatorial Associate, Vertebrate Paleontology Museum Of Comparative Zoology, Harvard University Somerville United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Heightened levels of maladaptive daydreaming are associated with COVID-19 lockdown, pre-existing psychiatric diagnoses, and intensified psychological dysfunctions: a multi-country study
Creators: name: E Somer
name: Abu-Rayya, Hisham
name: A Schimmenti
name: B Metin
name: R Brenner
name: E Ferrante
name: B Göçmen
name: A Marino
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © Copyright © 2020 Somer, Abu-Rayya, Schimmenti, Metin, Brenner, Ferrante, Göçmen and Marino. The COVID-19 pandemic has been spreading globally since December 2019, bringing with it anxieties, mortal risk, and agonizing psychological suffering. This study aimed to explore the relationship between maladaptive daydreaming (MD)—an addictive mental behavior to vivid fantasy associated with distress and functional impairment—and forced COVID-19 pandemic-related self-isolation and quarantine. Previous literature indicated that individuals employ MD for the regulation of distress and boredom, wish fulfillment, and entertainment experiences. The literature on the impact of the COVID-19 pandemic on mental health identifies a flareup in psychological difficulties in the general population. In this study we explored the associations between the pandemic threat and mental health indices among individuals with MD. We surveyed 1,565 adults from over 70 countries who responded to calls for participants posted in online MD communities and other general social media sites. Probable MD was determined based on an empirically derived cut-off score on a pertinent measure. After controlling for sociodemographic variables, a series of MANCOVAs, followed by post-hoc ANCOVAs, revealed that individuals with probable MD who were observing lockdown restrictions reported having spent more time in fantasy, experienced more intense and vivid daydreaming, and had a stronger urge to daydream than other participants. Similar statistical procedures indicated that, individuals with probable MD who reported pre-existing anxiety and depression disorders described a greater urge to daydream due to the pandemic and greater difficulty to control this addictive behavior. Compared to individuals with likely normal daydreaming, individuals with suspected MD reported more pandemic-attributed deterioration on a wide array of psychological distress indices. Our data show that the current worldwide pandemic threat is connected with an elevated intensity of this addictive form of mental activity, and that MD is associated with the exacerbation of psychological distress and dysfunction rather than with beneficial regulation of the experienced stressor.
Recent discoveries on the involvement of Krüppel-like factor 4 in the most common cancer types
Creators: name: A Taracha-Wisniewska
name: G Kotarba
name: Dworkin, Sebastian
name: T Wilanowski
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest that KLF4 is a tumor suppressor. However, the functioning of KLF4 is regulated at many levels. These include regulation of transcription, alternative splicing, miRNA, post-translational modifications, subcellular localization, protein stability and interactions with other molecules. Simple experiments aimed at assaying transcript levels or protein levels fail to address this complexity and thus may deliver misleading results. Tumor subtypes are also important; for example, in prostate cancer KLF4 is highly expressed in indolent tumors where it impedes tumor progression, while it is absent from aggressive prostate tumors. KLF4 is important in regulating response to many known drugs, and it also plays a role in tumor microenvironment. More and more information is available about upstream regulators, downstream targets and signaling pathways associated with the involvement of KLF4 in cancer. Furthermore, KLF4 performs critical function in the overall regulation of tissue homeostasis, cellular integrity, and progression towards malignancy. Here we summarize and analyze the latest findings concerning this fascinating transcription factor.
An α-Cyanostilbene derivative for the enhanced detection and imaging of amyloid fibril aggregates
Creators: name: Marzano, Nicholas R
name: Wray, Kelly M
name: Johnston, Caitlin L
name: Paudel, Bishnu P
name: Hong, Yuning
name: van Oijen, Antoine
name: Ecroyd, Heath
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The aggregation of proteins into amyloid fibrils has been implicated in the pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Benzothiazole dyes such as Thioflavin T (ThT) are well-characterized and widely used fluorescent probes for monitoring amyloid fibril formation. However, existing dyes lack sensitivity and specificity to oligomeric intermediates formed during fibril formation. In this work, we describe the use of an α-cyanostilbene derivative (called ASCP) with aggregation-induced emission properties as a fluorescent probe for the detection of amyloid fibrils. Similar to ThT, ASCP is fluorogenic in the presence of amyloid fibrils and, upon binding and excitation at 460 nm, produces a red-shifted emission with a large Stokes shift of 145 nm. ASCP has a higher binding affinity to fibrillar α-synuclein than ThT and likely shares the same binding sites to amyloid fibrils. Importantly, ASCP was found to also be fluorogenic in the presence of amorphous aggregates and can detect oligomeric species formed early during aggregation. Moreover, ASCP can be used to visualize fibrils via total internal reflection fluorescence microscopy and, due to its large Stokes shift, simultaneously monitor the fluorescence emission of other labelled proteins following excitation with the same laser used to excite ASCP. Consequently, ASCP possesses enhanced and unique spectral characteristics compared to ThT that make it a promising alternative for the in vitro study of amyloid fibrils and the mechanisms by which they form.
Estratégias utilizadas pelo enfermeiro na educação em saúde para o autocuidado Mellitus Tipo I: revisão integrativa.
Creators: name: Eduarda Mendes, Giovana
name: Silva Ramos de Souza, Jhuliano
name: Cristina Faria, Elaine
name: JERONIMO DE ALMEIDA SILVA, LUCIANA
name: Borges de Oliveira, Maria Vitória
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 420603
subject: Health promotion

description: RESUMOO Diabetes Mellitus Tipo 1 (DM1) é uma condição crônica que afeta milhões de pessoas globalmente, e o autocuidado desempenha papel fundamental no controle e manejo da doença. A educação em saúde é crucial para promover práticas adequadas de autocuidado entre os portadores de DM1. Este estudo tem como objetivo realizar uma revisão integrativa das evidências científicas disponíveis sobre as estratégias de educação em saúde empregadas pelos enfermeiros para apoiar o autocuidado de pacientes com DM1. Para alcançar esse objetivo, foi realizada uma pesquisa nas bases de dados BDENF, LILACS, MEDLINE, PubMed e Web of Science (WOS), visando identificar artigos publicados entre 2015 e 2024 que abordem essa temática. Serão utilizados descritores controlados das Ciências da Saúde (DeCS) para as bases LILACS e MeSH para as demais bases de dados. Os resultados serão apresentados em formato de síntese, destacando as principais estratégias adotadas pelos enfermeiros na educação em saúde para promover o autocuidado entre os portadores de DM1.
MUSSEL MEMORY: Digization of the Unionida at the Buffalo Museum of Science
Creators: name: Langle, Paige
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on MUSSEL MEMORY: Digization of the Unionida at the Buffalo Museum of Science by Collections Manager Of Zoology Paige Langle of Collections Manager Of Zoology Buffalo Museum Of Science Buffalo United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Sending Mixed Messages on Combatting the Use of Child Soldiers Through Unilateral Economic Sanctions: The U.S.'s Manipulation of the Child Soldiers Prevention Act of 2008
Creators: name: Boyland, Addison L.
Publisher: name: Michigan State University College of Law
Year: 2014
Subjects: subject: International law
subject: Human rights

description: Article published in the Michigan State International Law Review.
description: Article published in the Michigan State International Law Review.
Protective efficacy of ramelteon on methotrexate-induced DNA damage
Creators: name: Türel, Gülçin Yavuz
name: Koşar, Pınar Aslan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Ramelteon (RMLT) is a melatonin receptor agonist that it has antioxidative and anti-inflammatory effects associated with DNA damage through different mechanisms of action. In this regard, we investigated the potential usefulness of RMLT as a protective agent against methotrexate (MTX)-induced DNA damage. Four groups were constituted from 32 Wistar albino rats: Negative control, RMLT, MTX, and MTX + RMLT. Twenty mg/kg MTX (i.p., single dose) and RMLT 10 mg/kg (oral, 7 days) was administered. Comet assay was used and the parameter %TailDNA was used to detect DNA damage. %TailDNA was 4.90 ± 0.19 in the control group, 7.85 ± 0.33 in the MTX group, 5.49 ± 0.24 in the RMLT group, and 5.86 ± 0.23 in the MTX + RMLT group. While there was a significant increase in DNA damage in the MTX-treated group compared to the control group, there was a significant reduction in DNA damage in the MTX + RMLT group, compared to the MTX group (p < 0.001). In conclusion, it was observed that combined treatment with RMLT significantly reduced MTX-induced DNA damage. Investigate the possible protective effect of RMLT against DNA damage caused by MTX using the comet method.The DNA damage of RMLT treated group was significantly reduced compared to group and MTX group. (p < 0.001).Combined treatment with MTX significantly reduces MTX-induced DNA damage. Investigate the possible protective effect of RMLT against DNA damage caused by MTX using the comet method. The DNA damage of RMLT treated group was significantly reduced compared to group and MTX group. (p < 0.001). Combined treatment with MTX significantly reduces MTX-induced DNA damage.
Ivermectin-induced toxicity in HepG2 cells and the protective effect of tetrahydrocurcumin and vitamin C
Creators: name: Miranda, Camila Araújo
name: Mansano, João Rodolfo Domingues
name: Mingatto, Fábio Erminio
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Ivermectin (IVM) is a semi-synthetic antiparasitic derived from abamectin, one of the natural avermectins. The liver promotes metabolism and excretion of IVM, representing a risk of toxicity to this organ. The use of antioxidants to alleviate damage caused by chemicals has been increasingly studied. Thus, the aim of this study was to evaluate the effects of IVM on HepG2 cells to elucidate the mechanisms related to its toxicity and the possible protection provided by tetrahydrocurcumin (THC) and vitamin C. HepG2 cells were treated with IVM (1–25 μM) for 24 and 48 h. IVM was cytotoxic to HepG2 cells, denoted by a dose-dependent decrease in cell proliferation and metabolic activity. In addition, IVM induced damage to the cell membrane at all tested concentrations and for both incubation times. IVM significantly decreased the mitochondrial membrane potential from concentrations of 5 μM (24 h) and 1 μM (48 h). Additionally, IVM showed a time- and dose-dependent decrease in cellular adenosine triphosphate levels. The levels of reduced glutathione were decreased in a time- and dose-dependent manner, while IVM stimulated the production of reactive oxygen and nitrogen species (RONS) at all tested doses, reaching rates above 50% following treatment at 7.5 μM (24 h) or 5 μM (48 h). Treatment with THC (50 μM) and vitamin C (50 μM) protected against IVM-induced cytotoxicity and RONS production. These results suggest that oxidative damage is involved in IVM-induced toxicity in HepG2 cells, and that THC and vitamin C can mitigate the toxic effects caused by the compound.
Rationale, design and methods protocol for participatory design of an online tool to support industry service provision regarding digital technology use ‘with, by and for’ young children
Creators: name: S Edwards
name: A Nolan
name: M Henderson
name: Grieshaber, Susan
name: K Highfield
name: A Salamon
name: H Skouteris
name: L Straker
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Adults who educate and care for young children are exposed to mixed-messages about what is in the best interests of young children in digital society. Such mixed-messaging makes adult decision-making about technology use in the best interests of young children hard to achieve. This project addresses this problem by working with leading organisations providing services related to quality digital media production, online-safety education, digital play and digital parenting. Using a Participatory Design approach, families, educators, industry partners and researchers will conduct mixed-methods investigations concerning: Relationships; Health and Well-being; Citizenship; and Play and Pedagogy to identify practices concerning technology use ‘with, by and for’ young children. Iterative design cycles will develop an Online Tool to support organisations providing services to young children and the adults responsible for their education and care. As society becomes more digital families and educators need new knowledge about what people do in digital society to inform their decision-making. This project will support organisations to use an empirically informed approach to service provision regarding using technologies in the best interests of young children.
Natural history collections and social impact in the context of the climate and ecological crises
Creators: name: Gladstone, Isla
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Natural history collections and social impact in the context of the climate and ecological crises by Senior Curator Natural Science Isla Gladstone of Senior Curator Natural Science Bristol Museums Bristol United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Sustainable antibiotic-free broiler meat production: current trends, challenges, and possibilities in a developing country perspective
Creators: name: MH Haque
name: Sarker, Subir
name: MS Islam
name: MA Islam
name: MR Karim
name: MEH Kayesh
name: MJA Shiddiky
name: MS Anwer
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Antibiotic-free broiler meat production is becoming increasingly popular worldwide due to consumer perception that it is superior to conventional broiler meat. Globally, broiler farming impacts the income generation of low-income households, helping to alleviate poverty and secure food in the countryside and in semi-municipal societies. For decades, antibiotics have been utilized in the poultry industry to prevent and treat diseases and promote growth. This practice contributes to the development of drug-resistant bacteria in livestock, including poultry, and humans through the food chain, posing a global public health threat. Additionally, consumer demand for antibiotic-free broiler meat is increasing. However, there are many challenges that need to be overcome by adopting suitable strategies to produce antibiotic-free broiler meat with regards to food safety and chicken welfare issues. Herein, we focus on the importance and current scenario of antibiotic use, prospects, and challenges in the production of sustainable antibiotic-free broiler meat, emphasizing broiler farming in the context of Bangladesh. Moreover, we also discuss the need for and challenges of antibiotic alternatives and provide a future outlook for antibiotic-free broiler meat production.
Acanthohelea Kieffer
Creators: name: Borkent, Art
name: Evenhuis, Neal L.
name: Dominiak, Patrycja
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ceratopogonidae
Acanthohelea

description: Subgenus ACANTHOHELEA Kieffer
medialuna Silva, Ferreira-Keppler & Cazorla, 2023: 486. Brazil (Amazonas).
description: Published as part of Borkent, Art, Evenhuis, Neal L. & Dominiak, Patrycja, 2025, The World Catalog of Biting Midges (Diptera: Ceratopogonidae): Additional Updates and Errata, pp. 245-268 in Zootaxa 5631 (2) on page 261, DOI: 10.11646/zootaxa.5631.2.2, http://zenodo.org/record/15370558
Genomic prediction of rust resistance in tetraploid wheat under field and controlled environment conditions
Creators: name: Azizinia, Shiva
name: Bariana, Harbans
name: Kolmer, James
name: Pasam, Raj
name: Sridhar Bhavani
name: Mumta Chhetri
name: Toor, Arvinder
name: Miah, Hanif
name: Hayden, Matthew
name: Carpio, Dunia Pino Del
name: Bansal, Urmil
name: Daetwyler, Hans
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Genomic selection can increase the rate of genetic gain in crops through accumulation of positive alleles and reduce phenotyping costs by shortening the breeding cycle time. We performed genomic prediction for resistance to wheat rusts in tetraploid wheat accessions using three cross-validation with the objective of predicting: (1) rust resistance when individuals are not tested in all environments/locations, (2) the performance of lines across years, and (3) adult plant resistance (APR) of lines with bivariate models. The rationale for the latter is that seedling assays are faster and could increase prediction accuracy for APR. Predictions were derived from adult plant and seedling responses for leaf rust (Lr), stem rust (Sr) and stripe rust (Yr) in a panel of 391 accessions grown across multiple years and locations and genotyped using 16,483 single nucleotide polymorphisms. Different Bayesian models and genomic best linear unbiased prediction yielded similar accuracies for all traits. Site and year prediction accuracies for Lr and Yr ranged between 0.56–0.71 for Lr and 0.51–0.56 for Yr. While prediction accuracy for Sr was variable across different sites, accuracies for Yr were similar across different years and sites. The changes in accuracies can reflect higher genotype × environment (G × E) interactions due to climate or pathogenic variation. The use of seedling assays in genomic prediction was underscored by significant positive genetic correlations between all stage resistance (ASR) and APR (Lr: 0.45, Sr: 0.65, Yr: 0.50). Incorporating seedling phenotypes in the bivariate genomic approach increased prediction accuracy for all three rust diseases. Our work suggests that the underlying plant-host response to pathogens in the field and greenhouse screens is genetically correlated, but likely highly polygenic and therefore difficult to detect at the individual gene level. Overall, genomic prediction accuracies were in the range suitable for selection in early generations of the breeding cycle.
Supplemental_Appendix_1 – Supplemental material for Surgery is no more effective than conservative treatment for Femoroacetabular impingement syndrome: Systematic review and meta-analysis of randomized controlled trials
Creators: name: Robson Massi Bastos
name: Júnior, Jorge Geraldo De Carvalho
name: Silva, Suellen Aline Martinez Da
name: Campos, Shirley Ferreira
name: Matheus Vieira Rosa
name: Prianti, Bruno De Moraes
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, Supplemental_Appendix_1 for Surgery is no more effective than conservative treatment for Femoroacetabular impingement syndrome: Systematic review and meta-analysis of randomized controlled trials by Robson Massi Bastos, Jorge Geraldo de Carvalho Júnior, Suellen Aline Martinez da Silva, Shirley Ferreira Campos, Matheus Vieira Rosa and Bruno de Moraes Prianti in Clinical Rehabilitation
sj-pdf-2-imr-10.1177_0300060520964662 - Supplemental material for Identification of prognostic immune genes in laryngeal cancer
Creators: name: Xiao, Huan
name: Su, Qi-Sheng
name: Li, Chao-Qian
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery

description: Supplemental material, sj-pdf-2-imr-10.1177_0300060520964662 for Identification of prognostic immune genes in laryngeal cancer by Huan Xiao, Qi-sheng Su and Chao-qian Li in Journal of International Medical Research