cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation into the molecular basis for the absence of dihydromyricetin-derived flavonoids in raspberry
Creators: name: Szu Tu, Chelsea Chiao-Ying
Publisher: name: University of British Columbia
Year: 2010

description: Red raspberry (Rubus idaeus) is considered a health-promoting food with antioxidant properties. Flavonoid-3',5'-hydroxylase (F3'5'H), of the CYP75 family, is a member of the cytochrome P450 superfamily that catalyzes hydroxylation reactions to yield dihydromyricetin (DHM)-derived flavonoids. Raspberry and other Rosaceae family members such as apple (Malus spp.) and peach (Prunus spp.) preferentially accumulate dihydroquercetin (DHQ)-derived flavonoids, while lacking the DHM types. This peculiarity was investigated by comparative genomics and functional genomics of the F3’5’H gene(s). To investigate the molecular basis for the lack of F3’5’H activity in raspberry that could be attributed to aberrations at the transcriptional level, I first validated DNA template quality and a PCR-based strategy for gene cloning in raspberry and found it to be feasible. Numerous PCR efforts failed to detect any F3’5’H transcripts in fruit cDNAs nor could F3’5’H gene(s) be detected in the raspberry genome. Apple and peach whole genome sequence data mining also did not identify F3’5’H. Taken together, I have shown that PCR, anthocyanin profiling, and comparative genomics data are corroborated and collectively make a strong case for the raspberry genome lacking an F3’5’H ortholog. Genetic complementation of the absence of DHM-derived flavonoids in raspberry and apple callus lines was undertaken through inoculation of Agrobacterium tumefaciens harbouring a recombinant vector with grapevine F3’5’H gene driven by the 35S promoter. I established raspberry callus lines derived from leaves as well as apple callus lines derived from fruit. I then showed that both raspberry and apple callus lines are amenable to Agrobacterium-mediated genetic transformation via GUS histochemical assay. I found that light together with nitrate and 2,4-D deficient culture medium rapidly and efficiently induced anthocyanin accumulation in apple callus. While anthocyanins and flavonols were readily detected in treated apple callus lines, only hydroxycinnamic acid derivatives and early pathway intermediates were detected in treated raspberry callus lines. PCR analyses were conducted on putative raspberry transgenic callus lines. It was found that F3’5’H gene expression was detected in actively proliferating raspberry transgenic callus lines, as well as F3’5’H gene insertion(s) in the raspberry transgenic callus genome in the same selected lines.
Study of The Adverse Effects of Environmental Contaminants on Gene Expression in Fish
Creators: name: Zare, Ava
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: ecotoxicology
subject: Endocrine disruption
subject: Mixture effect
subject: EDCs
subject: mRNA expression
subject: Transcriptomics

description: The presence of contaminants with hormone-like activity and their potential harmful effects on the aquatic ecosystems has been a major concern for over three decades. Despite the presence of very low levels of environmental contaminants in Alberta rivers, the occurrence of feminization has been reported in these sites. Bisphenol A (BPA), Nonylphenol (NP) and Bis(2-ethylhexyl)phthalate (DEHP), which are known as weak environmental estrogens, were found to be among the most abundant contaminants in the Oldman River. The primary goal of this thesis was to investigate the in vivo effects of BPA, NP, and DEHP at environmentally relevant concentrations, individually and in a mixture, on gene expression patterns in goldfish (Carassius auratu) and fathead minnows (Pimephales promelas) under controlled laboratory conditions. Results of my study indicate that these contaminants at very low concentrations have endocrine disrupting abilities in a gender-specific manner. In addition, the altered transcript levels suggest that growth, steroidogenesis, gonadal development, and sperm biosynthesis might be possibly disrupted as a result of exposure to low concentration of endocrine disrupting compounds (EDCs). The findings in this thesis indicate that the mRNA expression levels in response to exposure to various doses of BPA do not always follow a monotonic curve. The low dose of BPA could dysregulate the genes involved in steroid synthesis and gamete production while higher concentrations could induce estrogenicity and activate the detoxification mechanism. Furthermore, this thesis provides novel information on the potential mechanisms, canonical pathways, and regulators that are associated with exposure to these contaminants. It was possible to identify the genes that were affected significantly by all treatment groups, which can be used as suitable biomarkers in ecotoxicology studies. I also demonstrate that the gene expression patterns were different when fish were exposed to a mixture of the contaminants. Overall, the results of this study provide novel information on mechanisms of actions and the health impacts of the tested contaminants, and identified a number of new biomarkers that can be used in environmental toxicity testing.
Digital.CSIC: impacto de la ciencia en acceso abierto (2013)
Creators: name: Bernal, Isabel
name: Oficina Técnica De Digital.CSIC
Publisher: name: Digital.CSIC
Year: 2013
Subjects: Copyright in a digital environment
Author's rights
Publishers policies for self-archiving
Licenses
Open access
Copyright en el entorno digital
Derechos de autor
Políticas de editores para el auto-archivo
Licencias
Acceso abierto

description: Esta presentación forma parte del curso impartido por la Oficina Técnica de Digital.CSIC "Digital.CSIC: desarrollo de contenidos. Gestión de Copyright. Impacto de la Ciencia en Acceso Abierto" celebrado en Madrid para el personal del CSIC los días 20-21-22 de marzo de 2013.-- El resto de presentaciones: Desarrollo de contenidos (http://hdl.handle.net/10261/73238) y Gestión de copyright (http://hdl.handle.net/10261/73242).-- La presentación está sujeta a una licencia Creative Commons Reconocimiento-Nocomercial-CompartirIgual 3.0 Unported
description: 1. Acceso verde hoy - 2. Críticas al modelo tradicional de medida de producción científica y nuevos criterios de medición - 3. Modelo tradicional de evaluación científica y nuevas propuestas - 4. La ventaja comparativa del acceso abierto. Tipos y ejemplos de mandatos de acceso abierto - 5. Repositorios institucionales y los CRIS
Race, Identity, and Culture
Creators: name: Hon, Ricky
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: race

description: This thesis addresses the racial ontology debate in the philosophy of race. The positions in this debate can be summarized along realist and antirealist dimensions as shown below: Realist: racial naturalism, racial constructionism Antirealist: racial skepticism I argue for racial constructionism. In particular, I argue for a Du Boisian-inspired cultural theory of race, whereby races are cultural groups. There is also a normative dimension to the racial ontology debate. There are three positions in this normative debate: conservationism, reconstructionism, and elminativism. Conservationism holds that our race talk should be conserved, reconstructionism holds that it should be reconstructed to treat race as something other than what it actually is, and eliminativism holds that it should be eliminated, either entirely or in certain respects. I argue for the cultural excellence thesis, a conservationist thesis which holds that we should conserve race talk based on the cultural value of races.
Outlining the human monocyte inflammatory cytokine response to dietary fat intake
Creators: name: Rahman, Mohammed Shamim
Publisher: name: Imperial College London
Year: 2019

description: Whilst mounting evidence implicates innate immune cells such as monocytes and macrophages in the development of atherosclerotic cardiovascular disease, evidence supporting dietary saturated fat intake as an established risk factor has been a topic of recent controversy. Little however, is understood about the effects of acute dietary saturated fat intake on monocytes and their subsets. A dietary interventional study with a coconut oil meal, rich in lauric acid was utilised to investigate human monocyte subset responses to saturated fat intake, comparing fasting and postprandial monocytes in healthy human donors. Utilising ex vivo and in vitro experiments, monocyte subsets differed at baseline in terms of surface marker expression and that the CD16low subset accumulates cytoplasmic lipid droplets to a greater extent than their CD16high counterparts, but that neither subset mounts an inflammatory response to dietary saturated fat exposure at either surface protein or gene expression level. Somewhat unexpectedly however, both subsets of postprandial monocytes lost relative migratory ability towards a chemokine gradient following postprandial lipids exposure and downregulated their inflammatory responses when stimulated by bacterial or viral TLR cues. The effects were augmented further when utilising higher concentrations of postprandial triglycerides in the form of triglyceride-rich lipoproteins and replicated with other dietary lipid sources such as palm and olive oil. Utilising gas and liquid chromatography mass spectrometry, I demonstrated that this surprising immunoparetic phenotype may in part be due to intracellular changes in lipid metabolism and the accumulation of isomers of docosahexaenoic acid (DHA), a polyunsaturated fat with anti- inflammatory properties. Although a significant body of work suggests intake of dietary saturated fat may provoke an inflammatory response, ingestion of lauric and other fatty acids used in this study, in fact resulted in an immunoparetic response, which may be of importance in understanding atherogenesis and healthy eating in the context of immunity.
Impact of rotational mixing on the global and asteroseismic properties of red giants
Creators: name: Eggenberger, P.
name: Lagarde, N.
name: Charbonnel, C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The influence of rotational mixing on the global parameters and asteroseismic properties of red giant stars is reviewed. While red giants are generally characterised by low surface rotational velocities, they may have been rotating much more rapidly during the main sequence, so that the rotational history of a star has a large impact on its properties during the red giant phase. For stars massive enough to ignite helium burning in non-degenerate conditions, rotational mixing leads to a significant increase of the stellar luminosity and shifts the location of the core helium burning phase to a higher luminosity in the HR diagram. This results in a change of the seismic properties of red giants and of the fundamental parameters of a red giant star as determined by performing an asteroseismic calibration. For red giants with a lower mass that undergo the helium flash, rotational mixing decreases the luminosity of the bump at solar metallicity changing thereby the global and asteroseismic properties of these stars.
description: Proc. of the workshop "Red Giants as Probes of the Structure and Evolution of the Milky Way" (Roma, 15-17 Nov 2010), Astrophysics and Space Science Proceedings, ISBN 978-3-642-18417-8 (eds. A. Miglio, J. Montalban, A. Noels). Part of RedGiantsMilkyWay/2011/ proceedings available at http://arxiv.org/html/1108.4406v1
Design, Synthesis and Evaluation of Novel Organoselenium Antioxidants
Creators: name: McNeil, Nicole Mary Ryan
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Chemistry--Organic
subject: organoselenium
subject: GPx
subject: mimetics
subject: Synthesis

description: Glutathione peroxidase is an antioxidant selenoenzyme that protects against oxidative stress by reducing peroxides in the presence of glutathione, a tripeptide thiol. Under certain circumstances, such as ischemic reperfusion, this protective mechanism can be overwhelmed. There is a need for potential therapeutics that mimic the function of this selenoenzyme that could be administered during abnormal levels of oxidative stress. Organoselenium compounds can function as antioxidants by catalytically reducing peroxides in the presence of thiols. The design, synthesis and evaluation of novel organoselenium compounds as glutathione peroxidase mimetics is the main focus of the work presented in this thesis. Of particular interest is the synthesis of water-soluble compounds. Two main strategies were investigated, the addition of hydroxymethyl groups or the PEGylation of known glutathione peroxidase mimetics. The addition of hydroxymethyl groups to cyclic seleninate esters and half aromatic half aliphatic selenides resulted in increased polarity of the compounds but only moderate catalytic activity. During the synthesis of these catalysts, an unexpected rearrangement was observed and the mechanism was thoroughly investigated. PEGylated compounds based on the half aromatic half aliphatic selenides were synthesized and demonstrated superior catalytic activity. With several novel organoselenium catalysts in hand, a water-based assay was desired for their evaluation. A D2O-based NMR assay was developed, validated and subsequently used to evaluate the novel organoselenium catalysts. In addition to using organoselenium compounds as glutathione peroxidase mimetics, oxidation catalysis is also possible when hydrogen peroxide is used as a stoichiometric oxidant. The observation of unusual kinetics associated with several cyclic seleninate esters, suggested that these catalysts could not only oxidize thiols to disulfides but could further oxidize disulfides to thiolsulfinates. Based on this observation, a new methodology for the oxidation of disulfides to thiolsulfinates using cyclic seleninate esters and hydrogen peroxide as a stoichiometric oxidant was developed. Finally, a spirodioxyselenurane was investigated using variable-temperature NMR and computational methods. This compound displayed unexpected proton NMR behaviour and a computational investigation into the effects of activated vibrational modes on chemical shift determined that the experimental observations were a result of temperature-dependent chemical shifts and not from dynamic exchange processes.
Digital.CSIC: desarrollo de contenidos (2013)
Creators: name: Román-Molina, Juan
name: Oficina Técnica De Digital.CSIC
Publisher: name: CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Year: 2013
Subjects: Copyright in a digital environment
Author's rights
Publishers policies for self-archiving
Licenses
Open access
Copyright en el entorno digital
Derechos de autor
Políticas de editores para el auto-archivo
Licencias
Acceso abierto
DSpace
Pasarela conCIENCIA > Digital.CSIC

description: Esta presentación forma parte del curso impartido por la Oficina Técnica de Digital.CSIC "Digital.CSIC: desarrollo de contenidos. Gestión de Copyright. Impacto de la Ciencia en Acceso Abierto" celebrado en Madrid para el personal del CSIC los días 20-21-22 de marzo de 2013.-- El resto de presentaciones: Gestión de copyright (http://hdl.handle.net/10261/73242) e Impacto de la ciencia en acceso abierto (http://hdl.handle.net/10261/73245).-- La presentación está sujeta a una licencia Creative Commons Reconocimiento-Nocomercial-CompartirIgual 3.0 Unported
description: Índice: 1. Introducción - 2. DSpace - 3. Pasarela conCiencia > Digital.CSIC - 4. Estrategia a seguir
Exploring New Directions In Multi-Modal Spatial Data Access
Creators: name: Hagedorn, Douglas
Publisher: name: Graduate Studies
Year: 2012
Subjects: subject: Geography
subject: Blindness
subject: Vision Impairment
subject: Geographic Information Systems
subject: Mapping
subject: Accessibility
subject: Spatial Data
subject: Cartography
subject: Human Computer Interaction
subject: User Interface

description: This thesis project uses a three tiered approach to explore new ways to make maps and Geographic Information Systems as accessible and useful for non-sighted people as they are for those with sight. The first tier explores how and why we have experienced difficulty when investigating non-visual cartography and devising innovative mapping strategies. The second tier draws upon critical cartographic theory and promising findings from extant research to propose an interaction-centric approach for research progress. The third tier proposes and demonstrates a prototype non-visual digital mapping system called the Fuse-Map Interface. Overarching topics include the adverse influence of assumptions and epistemological traditions in non-visual cartography, the importance of reflexive map interactions that enable the synthesis of meaning from representations of spatial data, and novel user interface technologies developed for non-visual human computer interactions. Necessary affordances for non-visual maps and new multi-modal human computer interfaces are also discussed in depth.
Anti-correlation and subsector structure in financial systems
Creators: name: Jiang, X. F.
name: Zheng, B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Finance (q-fin.GN)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: With the random matrix theory, we study the spatial structure of the Chinese stock market, American stock market and global market indices. After taking into account the signs of the components in the eigenvectors of the cross-correlation matrix, we detect the subsector structure of the financial systems. The positive and negative subsectors are anti-correlated each other in the corresponding eigenmode. The subsector structure is strong in the Chinese stock market, while somewhat weaker in the American stock market and global market indices. Characteristics of the subsector structures in different markets are revealed.
description: 6 pages, 2 figures, 4 tables
Las obras compartidas de Octavio Paz: práctica y poética de la colaboración
Creators: name: Dunsmoor, Helena Amber
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Literature--Latin American
subject: Paz, Octavio
subject: Mexican literature
subject: artistic collaboration
subject: poetry
subject: visual arts
subject: Rojo, Vicente
subject: Katayama, Toshihiro
subject: Paz, Marie José
subject: Tomlinson, Charles
subject: poetics
subject: "Homenaje y profanaciones"
subject: Translation
subject: influence

description: Beginning with the observation that collaborative projects by Octavio Paz (1914-1998) and other writers and visual artists have not yet been addressed in a comprehensive way in literary criticism, I propose the need for a detailed study of these same works. My main research questions involve the relationship of Paz’s collaborative writings to his entire oeuvre. This thesis accentuates the voices and contributions of individuals who worked with Paz throughout his career, drawing in part on personal interviews I have conducted with some of Paz’s collaborators. The first chapter delineates a theory of collaboration based on prose writings by Paz, Dámaso Alonso, Harold Bloom and Gabriel Zaid. Closely related to Paz’s poetics of otherness, this theory in fact sheds light on all of Paz’s writing. I examine the mechanics and ethics of collaboration in *Discos visuales* (with Vicente Rojo), *Renga* (with Jacques Roubaud, Edoardo Sanguineti and Charles Tomlinson), *3 Notations/3 Rotations* (with Toshihiro Katayama) *Airborn/Hijos del aire* (with Charles Tomlinson), *Figuras y figuraciones* (with Marie José Paz) and two uncollected poems (“Festín lunar” with Fouad el-Etr and “Poema de la amistad” with Agyeya and Shikrant Verma). This allows me to discuss relationships between bodies of writing as well as between writing and visual representations, since Rojo, Katayama and Marie José Paz all work in visual mediums. I also base an analysis of four of Paz’s solo poems on the poetics of collaboration (“Solo a dos voces”, “Homenaje y profanaciones”, “Respuesta y reconciliación. Diálogo con Francisco de Quevedo” and “Hermandad”). In the conclusion I consider how Paz’s tireless practice and theory of translation also contribute to an overall poetics of collaboration in the sense of homage, influence and rewriting. The thesis concludes with another proposed poetics that can be seen as a continuation or evolution of the poetics of collaboration.
Buenas prácticas para la digitalización de documentos destinados al repositorio Digital.CSIC
Creators: name: Bernal, Isabel
name: Santamarina De La Varga, Carolina
name: Oficina Técnica De Digital.CSIC
name: Román-Molina, Juan
Publisher: name: CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Year: 2013
Subjects: Buenas prácticas
Digitalización a nivel de usuario
Digital.CSIC

description: 11 páginas, incluye diversas imágenes de buenas y malas prácticas y un glosario.
description: Esta guía ofrece unas buenas prácticas para la digitalización de documentos en el repositorio institucional Digital.CSIC: digitalización a nivel usuario. Estos documentos deben cumplir con unos estándares mínimos de calidad y para ello se repasan los aspectos más relevantes a tener en cuenta.
Pholcus kangding Zhang & Zhu 2009, sp. nov.
Creators: name: Zhang, Feng
name: Zhu, Ming-Sheng
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Pholcidae
Pholcus
Pholcus kangding

description: Pholcus kangding sp. nov. (Fig. 20) Types. Male holotype, 5♂, 6♀ paratypes, CHINA: Sichuan Province, Kangding County [30°N, 101°54’E], July 16, 2000, leg. M. S. Zhu, F. Zhang and J. X. Zhang (MHBU). Diagnosis. Among its close Pholcus relatives (see the remark of P. clavatus), this species is very similar to P. zhangae sp. nov. in the shapes of the palpal bulb, both with branched appendices of palpal bulb (Figs. 20H and 63I). P. kangding sp. nov. can be distinguished from the latter by the shape of the procursus (Figs. 20G–I), by the smaller club-shaped epigynal apophysis (Fig. 20A), and by the cephalic region without brown slender central marks (Fig. 20C). Etymology. The species name refers to the type locality. It is a noun in apposition. Description. Male (holotype): total body length 4.2: cephalothorax 1.3 long, 1.5 wide; abdomen 2.9 long, 1.6 wide. Leg I: 41.7 (10.8+0.7+10.2+17.5+2.5), tibia II: 6.7, tibia III: 4.2, tibia IV: 5.4; tibia I L/D: 64. Prosoma shape as in Fig. 20C. Carapace short, broad and almost circular, ochre, with pair of brown mark broadly connecting to ocular area. Cephalic region raised, without brown central marks, ocular area dark yellow. Clypeus 0.46, dark ochre, without marks. Distance AME–AME 0.06. Diameter AME 0.09, ALE 0.14, PME 0.12, PLE 0.13. Chelicerae as in Fig. 20E, with pair of black apophyses distally, pair of unsclerotized nipple-like apophyses proximolaterally and pair of small unsclerotized rounded apophyses proximocentrally. Labium light yellow. Endites slightly gray. Sternum dark gray, with irregular yellow patches centrally and laterally as in Fig. 20F. Femora, patellae and tibiae ochre, with dark rings, metatarsi and tarsi brown. Abdomen cylindrical, pale ochre, dorsum with small brown patterns as in Fig. 20C. Venter pale brown. Palps as in Figs. 20H and 20I, bulb with fan-like uncus, appendix with a median branch. Procursus as in Fig. 20G. Tarsal organ capsulate. Variation. Tibia I in five other males: 9.4–10.0 (mean: 9.7). Body length in five other males 4.0–4.2. Female: in general very similar to male. Total length of bodies 4.1–4.7. A specimen measured (paratype), total length 4.7: cephalothorax 1.2 long, 1.3 wide; abdomen 3.5 long, 1.8 wide. Tibia I: 6.5. Distance AME–AME 0.05. Diameter AME 0.08, ALE 0.13, PME 0.11, PLE 0.12. Epigynum roughly oval as in Fig. 20A, with a bottle-cork-shaped apophysis on the top. Dorsal view as in Fig. 20B, with M-shaped sclerotized arch anteriorly and a pair of oval pore plates. Distribution. Known from type locality only.
description: Published as part of Zhang, Feng & Zhu, Ming-Sheng, 2009, A review of the genus Pholcus (Araneae: Pholcidae) from China, pp. 1-114 in Zootaxa 2037 (1) on page 43, DOI: 10.11646/zootaxa.2235.1.2, http://zenodo.org/record/5317608
Digital.CSIC: Indicadores de impacto y herramientas de colaboración en acceso abierto (2014)
Creators: name: Bernal, Isabel
name: Oficina Técnica De Digital.CSIC
Publisher: name: CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Year: 2014
Subjects: Open access mandates
Open access comparative advantage
Value added services in repositories
New impact indicators
Evaluation reform
Rise of gold/hybrid open access
Open peer review
Quality journals indicators
Mandatos de acceso abierto
Ventaja comparativa del acceso abierto
Servicios de valor añadido para repositorios
Nuevos indicadores de impacto
Reforma de evaluación científica
Crecimiento de acceso abierto dorado e híbrido
Nueva revisión por pares
Indicadores de calidad de revistas

description: Esta presentación forma parte del curso impartido por la Oficina Técnica de Digital.CSIC "Digital.CSIC: contenidos. Derechos de autor y políticas editoriales. Indicadores de impacto y herramientas de colaboración en Acceso Abierto" celebrado en Madrid para el personal del CSIC los días 24-25-26 de marzo de 2014.-- El resto de presentaciones: Contenidos (http://hdl.handle.net/10261/95797) y Derechos de autor y políticas editoriales (http://hdl.handle.net/10261/95802).-- La presentación está sujeta a una licencia Creative Commons de conocimiento-NoComercial-CompartirIgual 4.0 Internacional de Creative Commons
description: La sesión repasa desarrollos en el modo en que se comunica, evalúa y mide el impacto de la ciencia en un entorno de acceso abierto. Entre ellos destacan el auge de nuevos indicadores de impacto de la producción científica, propuestas para reformar los sistemas de evaluación, nuevos métodos de revisión por pares, servicios de valor añadido para repositorios, crecimiento de mandatos y políticas de acceso abierto de agencias financiadoras y la ventaja comparativa del acceso abierto.
description: 1. La ventaja comparativa del acceso abierto y ascenso de revistas de acceso abierto - 2. Mandatos de acceso abierto de agencias financiadoras de investigación - 3. Propuestas de reforma de sistemas de evaluación científica - 4. Nuevas métricas de impacto y nuevos procesos de evaluación - 5. Estrategias de difusión y reutilización de contenidos - 6. Otras cuestiones
Economic Evaluation of a Human Papillomavirus Vaccination Program for Grade 5 Boys in Alberta
Creators: name: Kim, Jong
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Public Health
subject: Human Papillomavirus
subject: Vaccination
subject: Economic Evaluation

description: Vaccination prevents Human papillomavirus (HPV) associated diseases. This study is a cost-utility analysis about adding boys to the HPV immunization program for girls in an Albertan and Canadian context, using a decision tree based model. Individuals in Grade 5 can be a boy or girl, and vaccinated or not vaccinated. Then, they can get a disease; and either survive or die. Included diseases were cervical, anal, head and neck, vaginal, vulvar, penile cancers, and anogenital warts. Parameters were adjusted to 2016 Canadian dollar and discounted 5% annually. The incremental cost effectiveness ratio (ICER) per quality adjusted life years for adding boys to the girls-only vaccination is $333,420. In sensitivity analysis, discount rate and herd immunity had the largest impact. Given the female coverage rate in Alberta, additional vaccination of boys would not be cost-effective because herd immunity reduces benefits. Policy justification of adding boys should expand beyond cost-effectiveness.
Gestión, difusión en acceso abierto y preservación de datos de investigación
Creators: name: Bernal, Isabel
name: Oficina Técnica De Digital.CSIC
Publisher: name: Digital.CSIC
Year: 2015
Subjects: Research data management
Data reuse tools
Open data policies
Research data and copyright
Data management plans
Metadata for research data
Gestión de datos de investigación
Herramientas para reutilización de datos
Políticas de datos abiertos
Datos de investigación y copyright
Planes de gestión de datos
Descripción de datos de investigación

description: Curso de formación para la comunidad científica y técnica CSIC impartido en la sede de URICI, Madrid, en 16-17 marzo, 2015. Material sujeto a licencia Creative Commons Attribution-Noncommercial-ShareAlike 4.0 International.
A Real-Time Demonstrator for Track Reconstruction in the CMS L1 Track-Trigger System Based on Custom Associative Memories and High-Performance FPGAs
Creators: name: Magazzu', Guido
name: Gentsos, Christos
name: Fedi, Giacomo
name: Magalotti, Daniel
name: Modak, Atanu
name: Palla, Fabrizio
name: Bilei, Gian Mario
name: Chowdhury, Suvankar Roy
name: Checcucci, Bruno
name: Tcherniakhovski, Denis
name: Galbit, Geoffrey Christian
name: Baulieu, Guillaume
name: Balzer, Matthias Norbert
name: Sander, Oliver
name: Viret, Sebastien
name: Storchi, Loriano
Publisher: name: Sissa Medialab
Year: 2018

description: A Real-Time demonstrator based on the ATCA Pulsar-IIB custom board and on the Pattern Recognition Mezzanine (PRM) board has been developed as a flexible platform to test and characterize low-latency algorithms for track reconstruction and L1 Trigger generation in future High Energy Physics experiments. The demonstrator has been extensively used to test and characterize the Track-Trigger algorithms and architecture based on the use of the Associative Memory ASICs and of the PRM cards. The flexibility of the demonstrator makes it suitable to explore other solutions fully based on high-performance FPGA device.
Servicios de DIGITAL.CSIC para gestión de datos de investigación en acceso abierto
Creators: name: Bernal, Isabel
name: Oficina Técnica De Digital.CSIC
Publisher: name: Digital.CSIC
Year: 2015
Subjects: Datos de investigación
Servicios de DIGITAL.CSIC
Research data
DIGITAL.CSIC services
Datos abiertos en Agricultura
Open data in Agriculture

description: Presentación para la comunidad científica y técnica del Instituto de Ciencias Agrarias (ICA) el 23 de abril de 2015 con motivo del Día Mundial del Libro y Derechos de Autor.
The changes in bone's nanostructure associated with bone fragility & bisphosphonate treatment
Creators: name: Tay, Tabitha Jia Hui
Publisher: name: Imperial College London
Year: 2020

description: The contribution of the nanostructure to whole bone strength has long been debated. However the impact of the collagen-mineral matrix on whole bone mechanics has yet to be tested. At the start of the study, bone volume and microarchitecture were found to not entirely account for bone strength, even though new ITS techniques were included, and thus it seemed possible that the gap could be attributed to the nanostructure. State-of-the-art synchrotron imaging was used to compare nanomechanics between bones from ageing non-fracture donors and ageing fracture patients, half of whom had been prescribed bisphosphonate. Fracture patients exhibited with lower tissue, collagen and mineral strains than non-fracture patients, suggesting that their nanostructures were less deformable. In addition, the fracture patients exhibited with wider mineral crystals, providing for larger surface areas for interfacial bonding with collagen fibrils, and thus preventing the unwinding and sliding of the matrix during loading. The less deformable matrix may reduce macroscopic strength via a cascade effect by easier initiation and growth of microcracks in the collagen-mineral matrix and limiting the bone’s ability to bend and absorb energy during a trip or fall. This new knowledge of the importance of the nanoscale deformation to whole bone strength could fill gaps in current diagnostics and treatments, if it were possible to measure deformation properties in vivo. Nanoindentation was developed to measure such deformations, and as such, a benchtop system was used to measure material properties of the three groups, and the data was correlated with nanostrain data. However, nanoindentation material properties and fibril and mineral strains were not correlated. In addition to the lack of correlation to microstructure and macro level strength and stiffness, it seems that nanoindentation does not measure material properties accurately and thus other alternatives need to be looked into for in-vivo measurements at the nanoscale.
Differential Abilities of Acutely and Chronically Denervated Nerve Derived Schwann Cells and Skin Derived Schwann Cells to Support Axonal Regeneration and Remyelination
Creators: name: Kumar, Ranjan
Publisher: name: Graduate Studies
Year: 2015
Subjects: subject: Biology--Cell
subject: Biology--Molecular
subject: Neuroscience
subject: Stem Cells
subject: Denervated Schwann Cell
subject: Nerve Injury and Repair
subject: Remyelination
subject: Regeneration

description: Despite the innate capacity of peripheral nervous system to regenerate, patients with severe nerve injury, especially those subjected to chronic nerve denervation, never regain full function, despite conventional nerve repair. The goal of this thesis is to iteratively evaluate a SC population derived from rodent and human skin towards the ultimate goal of improved autologous cell transplantation therapy to augment nerve repair. Skin derived precursors (SKPs) are multipotent stem cells with phenotypic similarities to neural crest cells. Upon transplantation into dysmyelinated or injured peripheral nerves, neonatal SKP-SCs survive, ensheath and myelinate regenerating axons and demonstrate superior indices of axonal regeneration. In this thesis, we demonstrate for the first time that, neonatal SKP-SCs therapy improves functional recovery in an array of behavioral tests in acute and delayed nerve repair models. Towards our goal of autologous therapies, we assessed adult SKP-SCs (aSKP-SCs), for promyelinating transcription factor expression, proliferation, neurite outgrowth, and remyelination. We also isolated and cultured SCs from acutely (day 5 post injury) and chronically (day 56 post injury) denervated nerves and performed detailed immunophenotypic characterization. Our data suggest that acutely denervated SCs are very potent but chronically denervated nerve SCs fail to exhibit comparable myelinating phenotype, exhibit retarded proliferation, show diminished neurite outgrowth, and demonstrate inferior in vitro/in vivo myelination as compared to acutely injured nerve SCs. We found that aSKP-SCs are very similar to acutely or embryonic nerve SCs and significantly superior to chronically denervated nerve SCs. We asked if there is a similar population of SCs in adult human skin, which may exhibit similarities to aSKP-SCs. We explored a novel population of SCs from human skin and compared them to human nerve derived SCs. Our data indicates that human skin derived SCs also express markers of pro-myelinating SC phenotype, and in preliminary experiments appears to have the capacity to ensheath and myelinate rodent axons in NOD-SCID mice. We further conclude that aSKP-SCs-like population of SCs exists in adult human skin, which shows great promise and requires further exploration to ascertain their potential for enhanced nerve repair in animal models of nerve injury, prior to clinical translation.
Mandatos de acceso abierto de agencias financiadoras: cumplimiento a través de DIGITAL.CSIC
Creators: name: Bernal, Isabel
name: Oficina Técnica De Digital.CSIC
Publisher: name: Digital.CSIC
Year: 2014

description: Sesión en CENIM, 4 marzo 2014.
description: La sesión se centró en explicar los principales mandatos de acceso abierto que tienen un impacto sobre la difusión de la producción científica CSIC, es decir, los de la Ley de la Ciencia, la Comisión Europea bajo Horizonte 2020 y el 7 Programa Marco, y el Consejo Europeo de Investigación. Los tres mandatos requieren el depósito de las publicaciones resultantes de los proyectos en el repositorio y empiezan a tratar también la difusión en acceso abierto de los datos científicos. La sesión presentó cuestiones importantes a tener en cuenta por los investigadores para poder cumplir con estos mandatos, en especial, las cuestiones de copyright, cuestiones relativas a las preferencias editoriales para publicar y las posibles excepciones al compromiso de acceso abierto. También se abordaron los servicios de apoyo bibliotecarios y de DIGITAL.CSIC en este contexto.
The Brain’s Structural and Functional Relationships with Language Ability in Preschool Children
Creators: name: Walton, Matt
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Neuroscience
subject: Radiology
subject: Psychology--Developmental
subject: MRI
subject: Neuroimaging
subject: Language
subject: Reading
subject: Pediatrics

description: The preschool years are a critical period of brain and language development, although little research has investigated relationships between language and brain structure or function during this age. This thesis contains an investigation of children aged 3.0-4.7 years who underwent assessments of phonological processing and speeded naming, measures that predict later reading ability. We used quantitative MRI methods to investigate brain structure and function, including diffusion tensor imaging, inhomogeneous magnetization transfer imaging, morphological analysis, and arterial spin labeling. Findings suggest that children with stronger language skills possess more mature patterns of brain structure and function. Our results are consistent with previous research in older children that suggest that structural and functional markers for reading disability exist before children begin formal reading instruction. Our results have identified neurological markers for children at risk for developing reading impairments, including reduced myelination, decreased cortical thickness, and reduced perfusion in the left hemisphere.
The velocity field of 2MRS Ks=11.75 galaxies: constraints on beta and bulk flow from the luminosity function
Creators: name: Branchini, Enzo
name: Davis, Marc
name: Nusser, Adi
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Using the nearly full sky Ks=11.75 2MASS Redshift Survey [2MRS]of ~45,000 galaxies we reconstruct the underlying peculiar velocity field and constrain the cosmological bulk flow within ~100. These results are obtained by maximizing the probability to estimate the absolute magnitude of a galaxy given its observed apparent magnitude and redshift. At a depth of ~60 Mpc/h we find a bulk flow Vb=(90\pm65,-230\pm65,50\pm65) km/s in agreement with the theoretical predictions of the LCDM model. The reconstructed peculiar velocity field that maximizes the likelihood is characterized by the parameter beta=0.323 +/- 0.08. Both results are in agreement with those obtained previously using the ~23,000 galaxies of the shallower Ks=11.25 2MRS survey. In our analysis we find that the luminosity function of 2MRS galaxies is poorly fitted by the Schechter form and that luminosity evolves such that objects become fainter with increasing redshift according to L(z)=L(z=0)(1+z)^(+2.7 +/-0.15).
description: 10 pages, 6 figures
On Stability in Gravity Drainage Oil Sand Recovery Process
Creators: name: Irani, Mazda
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Engineering--Petroleum
subject: Fingering
subject: Subcool
subject: Stability
subject: SAGD
subject: Liquid Pool
subject: Nsolv Process
subject: Observation Well

description: The controlling feature of steam-based recovery processes is heat transfer from the steam chamber to the formation – the greater the heat flux, the larger the oil volume heated and the higher the oil drainage rate. Stability phenomena in SAGD occur both at the edge of the chamber and at the liquid pool that exists above the production well. Previous studies have demonstrated that instability at the steam chamber edge can enhance heat transfer there by creating limited-amplitude steam fingers which enlarge the heat transfer area thus leading to greater thermal efficiency of the recovery process. In the research documented in this thesis, the stability between steam condensate and bitumen at the edge of the chamber is explored by deriving a new steam pressure diffusion equation. The results show that the stability is controlled by the interface velocity and water-phase hydraulic diffusivity. Also, the results demonstrate that at typical SAGD operation conditions, the chamber edge is unstable. In the liquid pool, the key measurement to maintain its stability is associated with steam trap control. The main objective is to keep subcool higher than set value which varies between 0 to 40° and even higher values. This study presents a new method to calculate the liquid pool level from temperature profile in observation wells, and liquid pool shrinkage as a function of time. Using this method, envelopes are suggested to differentiate three different regimes: “stable production”, “liquid pool depletion” and “steam breakthrough limit”. In solvent-based liquid pool trap control, analysis of the Nsolv field results and stability analysis suggests that vapour breakthrough is part of the process but can be minimized by operating at temperatures greater than second subcool limit.
The impact of archaeal histones on a na ̈ıve prokaryote
Creators: name: Rojec, Maria
Publisher: name: Imperial College London
Year: 2020

description: The packaging of DNA in chromatin is an important determinant of transcription, replication and recombination. Prokaryotic DNA is thought to be permissive and accessible to the transacriptional machinery. In contrast, eukaryotic chromatin is thought to be repressive for transcription (Struhl, 1999). To ask whether histones are sufficient for the transition from a permissive (open) to a repressive (closed) transcriptional state, we introduced histones HMfA and HMfB from the methanogenic archaeon Methanothermus fervidus into a bacterial host, Escherichia coli. We found that archaeal histones form dynamic nucleosomal arrays composed of oligomerising histone dimers in the E. coli genome, just as they do in Archaea. The positioning of archeal histones is determined by the underlying E. coli DNA sequence, as well as bacterial transcription and replication during active growth. Archaeal histones are surprisingly well tolerated in rich medium and under a variety of stresses, with the exception of treatments that directly affect cellular DNA topology or cause DNA damage. Even though E. coli lacks chromatin remodeling enzymes to actively reshape the chromatin landscape, archaeal histones have at best weak repressive local effects on transcription. These findings suggest that archaeal histones, similar to bacterial chromatin components, are not as restrictive as their eukaryotic counterparts, and may define a “proto-restrictive” ground state.
Additional file 1 of Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Creators: name: Llinàs-Arias, Pere
name: Ensenyat-Mendez, Miquel
name: Íñiguez-Muñoz, Sandra
name: Orozco, Javier I. J.
name: Valdez, Betsy
name: Salomon, Matthew P.
name: Matsuba, Chikako
name: Solivellas-Pieras, Maria
name: Bedoya-López, Andrés F.
name: Sesé, Borja
name: Mezger, Anja
name: Ormestad, Mattias
name: Unzueta, Fernando
name: Strand, Siri H.
name: Boiko, Alexander D.
name: Hwang, E Shelley
name: Cortés, Javier
name: DiNome, Maggie L.
name: Esteller, Manel
name: Lupien, Mathieu
name: Marzese, Diego M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer
subject: Plant Biology

description: Supplementary Material 1. It includes supplementary figures, table S1, and extended methods.
Broad band invisibility cloak made of normal dielectric multilayer
Creators: name: Xu, Xiaofei
name: Feng, Yijun
name: Xiong, Shuai
name: Fan, Jinlong
name: Zhao, Jun-Ming
name: Jiang, Tian
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present the design, fabrication and performance test of a quasi three-dimensional carpet cloak made of normal dielectric in the microwave regime. Taking advantage of a simple linear coordinate transformation we design a carpet cloak with homogeneous anisotropic medium and then practically realize the device with multilayer of alternating normal dielectric slabs based on the effective medium theory. As a proof-of-concept example, we fabricate the carpet cloak with multilayer of FR4 dielectric slabs with air spacing. The performance of the fabricated design is verified through full-wave numerical simulation and measurement of the far-field scattering electromagnetic waves in a microwave anechoic chamber. Experimental results have demonstrated pronounced cloaking effect in a very broad band from 8 GHz to 18 GHz (whole X and Ku band) due to the low loss, non-dispersive feature of the multilayer dielectric structure.
description: 10 pages, 4 figures. Accepted in Appl. Phys. Lett
Settling Rates of Asphaltenes and Solids from Diluted Bitumen
Creators: name: Casas, Yoshinori
Publisher: name: Graduate Studies
Year: 2017
Subjects: Chemistry
Engineering--Chemical
Engineering--Petroleum

description: One method to remove fine solids from bitumen prior to transportation is to add a paraffinic solvent to precipitate asphaltenes, which flocculate with the fine solids and enhance the settling rate. The process conditions, solvent type, and ratio of solvent to bitumen must be optimized to achieve practical settling rates while minimizing solvent and bitumen losses. A settling model was developed that requires the size distribution, density, and fractal dimension of the flocculated asphaltene/solids, and the density and viscosity of the fluid as inputs. Settling rates were measured using visual and sampling methods for three diluted bitumen mixtures: n-pentane/WC-B-A3, n-heptane/WC-B-A3 and n-heptane/WC-B-B2. The floc size distributions were measured using micrography and the Focused Beam Reflectance Method. Densities and viscosities were calculated from the component properties. The fractal dimension was determined from sediment volumes. The settling model predicted the settling rates to within 15%, except near the onset of precipitation.
MOESM1 of Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism
Creators: name: Xu, Qin
name: Bai, Chenxiao
name: Liu, Yiqi
name: Song, Lili
name: Tian, Lin
name: Yan, Yunfeng
name: Zhou, Jinfeng
name: Zhou, Xiangshan
name: Zhang, Yuanxing
name: Cai, Menghao
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 1. Additional figures and tables.