cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Systemic inflammation in COPD: effects on skeletal muscle and the cardiovascular system?
Creators: name: Mohan, Divya
Publisher: name: Imperial College London
Year: 2016

description: Chronic obstructive pulmonary disease (COPD) is increasingly recognised to be heterogeneous and complex, with several extra-pulmonary manifestations, necessitating categorisation of patients in order to better tailor treatments towards distinct phenotypes. Cardiovascular disease and peripheral skeletal muscle dysfunction are amongst the most important comorbidities in COPD, with systemic inflammation proposed as a potential mechanistic link. Therefore, there is considerable interest in novel anti-inflammatory drugs, as well as understanding underlying mechanisms. An observational study of 729 COPD subjects confirms that cardiovascular co-morbidity and quadriceps weakness affect 46.3% and 43.6% of the study population respectively. However, these comorbidities are present as distinct manifestations, and do not overlap to present as a combined phenotype more often than expected. Markers of systemic inflammation (fibrinogen, white cell count and C-reactive protein), relate neither to arterial stiffness, quadriceps weakness nor to diaphragm weakness as measured via sniff nasal inspiratory pressure (SnIP). Consistent with the above findings, Losmapimod, a novel anti-inflammatory p38-MAPK inhibitor, did not improve cardiovascular or muscle performance, measured as arterial stiffness, SnIP and 6-minute walk distance, in a double-blind, randomized control study of 67 COPD subjects. Definitive evidence of whether inflammatory and/or atrophy pathways are up-regulated in human quadriceps is currently lacking, possibly due to the use of whole muscle samples failing to account for altered fibre type composition amongst COPD subjects. Quadriceps biopsy specimens from 12 COPD and 6 healthy subjects were used to separate type I and type II muscle fibres via laser capture microdissection (LCM). In this pilot study, there was evidence of lower MURF-1 and Atrogin-1 expression in type II fibres of COPD versus control subjects, a difference that was not apparent in whole muscle samples. Therefore LCM can potentially provide a more sensitive, novel method to identify therapeutic targets for skeletal muscle dysfunction.
The morphological identification of the rapidly evolving population of faint galaxies
Creators: name: Glazebrook, Karl
name: Ellis, Richard
name: Santiago, Basilio
name: Griffiths, Richard
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The excess numbers of blue galaxies at faint magnitudes are a long-standing cosmological puzzle. We present new number-magnitude counts as a function of galactic morphology from the first deep fields of the Cycle 4 Hubble Space Telescope {\it Medium Deep Survey} project. From a sample of 301 galaxies we define counts for elliptical, spiral and irregular/peculiar galaxies to $I=22$. We find two principal results. Firstly the elliptical and spiral galaxy counts both follow the predictions of high-normalisation no-evolution models at all magnitudes, indicating that regular Hubble types evolve only slowly to $z\sim 0.5$. Secondly we find that irregular/peculiar galaxies, including multiple-peaked, possibly merging, objects, have a very steep number-magnitude relation and greatly exceed predictions based on proportions in local surveys. These systems make up half the total counts by $I=22$ and imply the rapidly-evolving component of the faint galaxy population has been identified.
description: MNRAS submitted, 6 pages, UUencoded compressed Postscript file, including figures. Postscript also available from http://www.ast.cam.ac.uk/~kgb/papers.html
Rosa villosa Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Rosales
Rosaceae
Rosa
Rosa villosa

description: Rosa villosa, spec. nov.
 3. Rosa foliis utrinque villosis, fructu spinoso. Hall. helv. 350.
 Rosa sylvestris pomifera major. Bauh. pin. 484.
 Habitat in Europa australi. ♄
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 491, DOI: 10.5281/zenodo.3931989
Learning Data Augmentation for Brain Tumor Segmentation with Coarse-to-Fine Generative Adversarial Networks
Creators: name: Mok, Tony C. W
name: Chung, Albert C. S
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: There is a common belief that the successful training of deep neural networks requires many annotated training samples, which are often expensive and difficult to obtain especially in the biomedical imaging field. While it is often easy for researchers to use data augmentation to expand the size of training sets, constructing and generating generic augmented data that is able to teach the network the desired invariance and robustness properties using traditional data augmentation techniques is challenging in practice. In this paper, we propose a novel automatic data augmentation method that uses generative adversarial networks to learn augmentations that enable machine learning based method to learn the available annotated samples more efficiently. The architecture consists of a coarse-to-fine generator to capture the manifold of the training sets and generate generic augmented data. In our experiments, we show the efficacy of our approach on a Magnetic Resonance Imaging (MRI) image, achieving improvements of 3.5% Dice coefficient on the BRATS15 Challenge dataset as compared to traditional augmentation approaches. Also, our proposed method successfully boosts a common segmentation network to reach the state-of-the-art performance on the BRATS15 Challenge.
Robustness and stability of complex systems
Creators: name: Rolando, Delphine
Publisher: name: Imperial College London
Year: 2015

description: The ability of complex systems to be stable has, for good reasons, been widely debated and studied. In this work we try to understand why some mathematical models of complex systems suggest that their probability of stability is very low. We will show that it is the full structure of the system that defines its stability, and it therefore cannot be deduced from overly simplified mathematical models. In particular the complexity of the network cannot be linked to its stability without considering other relevant factors. We then go on to look at how such stable complex networks can evolve and show that minimal input can be sufficient to grow networks that are almost always stable. The rest of our work focusses on a different type of robustness, the robustness to shock propagation. In particular, we are interested in the impact of uncertainty on optimised networks systems and the methods that can be used to reduce it. In order to do so we consider a lattice model and a simple network model of the financial system and look at the fragility that arises from their optimisation under uncertainty. We find that using a more limited amount of information during the optimisation process, and reducing the level of optimisation can help limit the fragility of the systems obtained. Finally, we consider whether simple measures can help predict the riskiness of the financial system under uncertainty. We use three measures that are not only simple but meaningful for the system considered, and we find that more often than not such measures do better than the usual, more complex methods.
MOESM1 of Evaluation of GFP reporter utility for analysis of transcriptional slippage during gene expression
Creators: name: Wons, Ewa
name: Koscielniak, Dawid
name: Szadkowska, Monika
name: Sektas, Marian
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Developmental Biology

description: Additional file 1: Figure S1. GFP fluorescence is proportional to a bacterial culture yield. The relative level of Gfp fluorescence in ER2566 cultures expressing 0 frame gfp (pETgfpA60) (circles) and − 1 frameshifted gfpA5-1 (pETminA2gfp-1) (diamonds) (1 mM IPTG by 1 h at 37 °C). The black line represents the regression line between normalized measurements of GFP fluorescence and bacterial pellet abundance, serially diluted (r2 = 0.998 and 0.992, as determined by regression analysis). Table S1. Plasmids used in this study. Table S2. List of oligonucleotides used in this study to amplify and duplex DNA annealing.
An exploration of the relationship between organisational culture, organisational identity and healthcare performance in a merged academic health science centre
Creators: name: Mottram, Anne
Publisher: name: Imperial College London
Year: 2015

description: This study makes a significant contribution to new knowledge in the field of mergers, organisational culture and organisational identity. For the first time evidence is found on the longevity of a ‘merger effect’ which impacts on staff perceptions of organisational culture and organisational identity. Seven years on from a merger there were statistically significant differences in the mean survey scores of staff employed pre-merger and those appointed post merger. In addition there was evidence of divergent views among staff with sub-cultures and multiple identities: Staff perceive culture and identity differently based on hierarchical ranking (more positively for non-managers) and occupational group (more positively for clinicians) and are affected differently by workplace stressors during a merger. There was evidence to support a relationship between culture and identity. Over time the dominant clinical academic logic was eroded, when the merged organisation adopted a competing professional and managerial logic. Staff used cultural cues to make sense of changes however senior staff did not influence the perceptions of subordinates. Links with performance, culture and identity were ambiguous. This mixed methods inquiry in a merged Academic Health Science Centre, employed an organisational survey with 1,978 respondents, in-depth interviews, descriptive statistics, regression analyses and thematic analysis to interpret the results and to triangulation research findings. Institutional logics is the exploratory lens NHS financial pressures necessitate developing new organisational models, transformations and mergers to achieve sustainability. Findings support debates on the length of time required to achieve cultural change following a merger, the time it takes for staff to identify with the new merged entity and proposes that merger plans should take into account the longevity effect in designing post-merger integration programmes and staff differences to maximise success, paying attention to fostering staff well-being during mergers.
Additional file 3: of Methods for conducting a double-blind randomized controlled clinical trial of three days versus five days of amoxicillin dispersible tablets for chest indrawing childhood pneumonia among children two to 59Â months of age in Lilongwe, Malawi: a study protocol
Creators: name: Ginsburg, Amy
name: May, Susanne
name: Evangelyn Nkwopara
name: Ambler, Gwen
name: McCollum, Eric
name: Tisungane Mvalo
name: Ajib Phiri
name: Lufesi, Norman
name: Sadruddin, Salim
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Appendix 2. Study protocol and statistical analysis plan. (DOC 636 kb)
Rosa villosa Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Rosales
Rosaceae
Rosa
Rosa villosa

description: Rosa villosa Linnaeus, Species Plantarum 1: 491. 1753.
"Habitat in Europa australi." RCN: 3738.
Lectotype (Nepi & al. in Jonsell & Jarvis in Nordic J. Bot. 22: 76. 2002): Herb. Burser XXV: 33 (UPS).
Current name: Rosa villosa L. (Rosaceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 800, DOI: 10.5281/zenodo.291971
Correlation length of X-ray brightest Abell clusters
Creators: name: Abadi, Mario G.
name: Lambas, Diego G.
name: Muriel, Hernán
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We compute the cluster auto-correlation function $ξ_{cc}(r)$ of an X-ray flux limited sample of Abell clusters (XBACs, \cite{ebe}). For the total XBACs sample we find a power-law fit $ξ_{cc}=(r/r_0)^γ$ with $r_0=21.1$ Mpc h$^{-1}$and $γ=-1.9$ consistent with the results of $R \ge 1 $ Abell clusters. We also analyze $ξ_{cc}(r)$ for subsamples defined by different X-ray luminosity thresholds where we find a weak tendency of larger values of $r_0$ with increasing X-ray luminosity although with a low statistical significance. In the different subsamples analyzed we find $21 < r_0 < 35 $ Mpc h$^{-1}$ and $-1.9< γ< -1.6$. Our analysis suggests that cluster X-ray luminosities may be used for a reliable confrontation of cluster spatial distribution properties in models and observations.
description: Accepted for publication in Astrophysical Journal
The Luminosity Function of the Coma Cluster Core for -25
Creators: name: Bernstein, G. M.
name: Nichol, R. C.
name: Tyson, J. A.
name: Ulmer, M. P.
name: Wittman, D.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We determine the luminosity function (LF) of galaxies in the core of the Coma cluster for M_R<=-11.4 (assuming H_0=75 km/s/Mpc), a magnitude regime previously explored only in the Local Group. Objects are counted in a deep CCD image of Coma having RMS noise of 27.7 R mag~arcsec$^{-2}$. A correction for objects in the foreground or background of the Coma cluster---and the uncertainty in this correction---are determined from images of five other high-latitude fields, carefully matched to the Coma image in both resolution and noise level. Accurate counts of Coma cluster members are obtained as faint as R=25.5, or M_R=-9.4. The LF for galaxies is well fit by a power law dN/dL\propto L^α, with α=-1.42\pm0.05, over the range -19.4
description: Submitted to AJ. Self-unpacking version of AASTeX source for 45p text and Postscript for Figures 3--8. Compressed postscript of 50p manuscript with all Figures embedded is available at ftp://astro.lsa.umich.edu/pub/get/comalf.tar.Z
Defining mechanisms of tissue destruction in tuberculosis-HIV co-infection and tuberculosis immune reconstitution inflammatory syndrome
Creators: name: Walker, Naomi Frances
Publisher: name: Imperial College London
Year: 2015

description: Tuberculosis (TB) is the leading cause of death in HIV-infected patients. The paradoxical TB-immune reconstitution inflammatory syndrome (TB-IRIS) complicates antiretroviral therapy (ART). Matrix metalloproteinases (MMPs) are implicated in TB immunopathology, causing pulmonary matrix degradation. I explored the hypothesis that MMPs drive immunopathology in TB-HIV co- infection. I also investigated invariant Natural Killer T (iNKT) cells, cytotoxic T cells with innate immune functions. In a cross-sectional study in Cape Town, South Africa, HIV-infected and uninfected TB patients were compared to respiratory symptomatic and healthy controls. In a longitudinal study of HIV-infected ART naïve TB patients from TB diagnosis, for the first 3 months of ART, patients who developed TB-IRIS were compared with those who did not. Clinical features of disease severity were recorded, induced sputum and plasma collected for MMP and cytokine quantification by multiplex, and plasma for procollagen III N-terminal propeptide (PIIINP) quantification. Peripheral blood iNKT cells were enumerated by flow cytometry, using CD1d tetramers. In the cross-sectional study, 227 patients were enrolled. TB and TB-HIV co- infection were associated with elevated sputum MMP-1, -3, and -8. MMP-1 was 33-fold higher in HIV-uninfected and 4-fold higher in HIV-infected TB patients, than corresponding controls. MMP-1 correlated with radiographic inflammation. Plasma PIIINP was increased in TB and TB-HIV co-infection and correlated with sputum MMPs and radiographic inflammation. In the longitudinal study, 49 HIV-infected TB patients were enrolled and followed up. 29 (59%) developed TB-IRIS. In TB-IRIS, sputum MMP-7 and MMP- 10 were elevated, prior to and during ART, in addition to plasma MMP-1, -3, and -8 and PIIINP. TB and HIV infection were associated with reduced iNKT cell frequencies. In TB-IRIS iNKT cell frequencies were elevated compared to non- IRIS controls. Elevated MMP activity in TB-HIV co-infection is a novel target for host-directed therapy. INKT cells may have a pathological or protective role in TB immunopathology. Further study is required.
Extending the wavelength coverage of frequency-doubled fibre lasers
Creators: name: Runcorn, Timothy
Publisher: name: Imperial College London
Year: 2015

description: The unique coherence properties of laser light has revolutionised modern life through fields as diverse as materials processing, optical communications and scientific research. Despite the enormous engineering progress made in developing laser systems into tools used in a wide range of applications, there are still many spectral regions where suitable laser sources are demanded. This thesis describes progress made towards developing practical and efficient nonlinear frequency conversion techniques to access some of these spectral regions, whilst exploiting the inherent benefits that master oscillator power fibre amplifier (MOPFA) systems offer. In particular, two of the developed sources were designed to satisfy the depletion beam requirements for stimulated emission depletion microscopy using the green fluorescent protein. The sources operated at 560 nm and were based on a frequency-doubled Raman amplifier that was pulse-pumped by an ytterbium MOPFA system. The first source developed proved that this architecture was effective at generating picosecond pulse trains at megahertz repetition rates with nanojoule pulse energy in a compact and alignment-free system. The second source improved on the design by adding temporal flexibility, increasing the efficiency and pulse energy and demonstrated that it was a completely turn-key solution. The third source extended the frequency-doubled pulse-pumped Raman amplifier concept to operation around 590 nm by utilising cascaded Raman amplification, whilst maintaining similar output characteristics. The final source developed operated around 780 nm and was based on direct frequency-doubling of an erbium MOPFA system. It was designed for subsequent nonlinear frequency conversion and featured high average power with flexible wavelength and temporal characteristics. Watt-level average powers and pulse energies of hundreds of nanojoules were obtained at every wavelength region, demonstrating that the implemented nonlinear frequency conversion techniques are a viable method for extending the wavelength coverage of MOPFA systems.
Using surrogate distributions to improve the convergence properties of gibbs-type samplers
Creators: name: Jiao, Xiyun
Publisher: name: Imperial College London
Year: 2016

description: Gibbs-type samplers are widely used tools for obtaining Monte Carlo samples from posterior distributions under complicated Bayesian models. Standard Gibbs samplers update component quantities of the parameter by sequentially sampling their conditional distributions under the target joint distribution. However, this strategy can be slow to converge if the components are highly correlated. We formalize a general strategy to construct more efficient samplers by replacing some of the conditional distributions with conditionals of a surrogate distribution. The surrogate distribution is designed to share certain marginal distributions with the target, but with lower correlations among its components. Although not necessarily recognized when they were introduced, a number of existing strategies for improving Gibbs can be formulated in this way (e.g., Marginal Data Augmentation, Partially Collapsed Gibbs sampling, Ancillarity-Sufficiency Interweaving Strategy, etc.). The use of surrogate distributions in Gibbs-type samplers may lead to incompatible conditional distributions and thus sensitivity to the order of the component draws. We propose a framework to combine different strategies involving surrogate distributions into a single coherent sampler that maintains the target stationary distribution and outperforms any of its component algorithms in terms of convergence. We use both theoretical arguments and numerical examples to illustrate the implementation and efficiency of our strategy. A problem in supernova cosmology has motivated our work and serves as a realistic testing ground for our methods. Finally, we correct two errors in the related Marginal Data Augmentation algorithms of Imai and van~Dyk (2005) that are quite popular for fitting multinomial probit models.
Additional file 9 of Characterization of tea (Camellia sinensis L.) flower extract and insights into its antifungal susceptibilities of Aspergillus flavus
Creators: name: Chen, Fangfang
name: Chen, Yu-Pei
name: Wu, Hongtan
name: Li, Ya
name: Zhang, Shudi
name: Ke, Jincheng
name: Yao, Jeng-Yuan
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Supplementary Material 9
NGC 7582: The Prototype Narrow-Line X-ray Galaxy
Creators: name: Schachter, Jonathan F.
name: Fiore, Fabrizio
name: Elvis, Martin
name: Mathur, Smita
name: Wilson, Andrew S.
name: Morse, Jon A.
name: Awaki, Hisamitsu
name: Iwasawa, Kazushi
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: NGC 7582 is a candidate prototype of the Narrow Line X-ray Galaxies (NLXGs) found in deep X-ray surveys. An ASCA observation shows the hard (> 3 keV) X-ray continuum of NGC 7582 drops 40% in ~6 ks, implying an AGN, while the soft band (< 3 keV) does not drop in concert with the hard continuum, requiring a separate component. The X-ray spectrum of NGC 7582 also shows a clear 0.5-2 keV soft (kT = 0.8 (+0.9,-0.3) keV or Gamma = 2.4 +/- 0.6; L(X) = 6 x 10**40 ergs s**-1) low--energy component, in addition to a heavily absorbed [N(H) = (6 +/- 2)\times 10**22 cm**-2 ] and variable 2-10 keV power law [Gamma = 0.7 (+0.3,-0.4); L(X) = (1.7-2.3) x 10**42 ergs s**-1]. This is one of the flattest 2-10 keV slopes in any AGN observed with ASCA. (The ROSAT HRI image of NGC 7582 further suggests extent to the SE.) These observations make it clear that the hard X-ray emission of NGC 7582, the most "narrow-line" of the NLXGs, is associated with an AGN. The strong suggestion is that all NLXGs are obscured AGNs, as hypothesized to explain the X-ray background spectral paradox. The separate soft X-ray component makes NGC 7582 (and by extension other NLXGs) detectable as a ROSAT source.
description: text: Latex2e 10 pages, including 1 table, and 2 postscript figures via psfig
Melting of the vortex lattice through intermediate hexatic fluid in a-MoGe thin film
Creators: name: Roy, Indranil
name: Dutta, Surajit
name: Choudhury, Aditya N. Roy
name: Basistha, Somak
name: Maccari, Ilaria
name: Mandal, Soumyajit
name: Jesudasan, John
name: Bagwe, Vivas
name: Castellani, Claudio
name: Benfatto, Lara
name: Raychaudhuri, Pratap
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The hexatic fluid refers to a phase in between a solid and a liquid which has short range positional order but quasi-long range orientational order. In the celebrated theory of Berezinskii, Kosterlitz and Thouless and subsequently refined by Halperin, Nelson and Young, it was predicted that a 2-dimensional hexagonal solid can melt in two steps: first, through a transformation from a solid to a hexatic fluid which retains quasi long range orientational order and then from a hexatic fluid to an isotropic liquid. In this paper, using a combination of real space imaging and transport measurements we show that the 2-dimensional vortex lattice in a-MoGe thin film follows this sequence of melting as the magnetic field is increased. Identifying the signatures of various transitions on the bulk transport properties of the superconductor, we construct a vortex phase diagram for a two dimensional superconductor.
description: New Data added in this version
Rosmarinus officinalis Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Lamiaceae
Rosmarinus
Rosmarinus officinalis

description: Rosmarinus officinalis, spec. nov.
 1. Rosmarinus. Hort. cliff. 14. Hort. ups. 11. Mat. med. 16. Roy. lugdb. 310.
 Rosmarinus spontaneus, latiore folio. Bauh. pin. 217.
 β. Rosmarinus hortensis, angustiore folio. Bauh. pin. 217.
 Habitat in Hispania , G.narbonensi , Galilaea . ♄
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 23, DOI: 10.5281/zenodo.3931989
Gene therapy for alpha-1-antitrypsin deficiency
Creators: name: Paul-Smith, Michael Christian
Publisher: name: Imperial College London
Year: 2016

description: Alpha-1-antitrypsin deficiency (AATD) is an autosomal recessive disorder characterised by low levels of the circulating anti-protease alpha-1-antitrypsin (hAAT). Low levels of pulmonary hAAT pre-disposes individuals to early-onset emphysema, and the efficacy of intravenous augmentation therapy with purified protein is the subject of debate. Gene therapy could be an alternative treatment strategy. In this thesis, “gold standard” viral and non-viral agents for airway gene transfer were assessed for their ability to produce alpha-1-antitrypsin. Key findings in this thesis are: 1. A single dose of gene therapy with the non-viral agent GL67A was not sufficient to produce hAAT in murine lung tissue homogenate or epithelial lining fluid (ELF). A repeat dosing regimen resulted in significant (p<0.01) but sub-therapeutic production of hAAT in ELF (treated: median 331 (range 0.0-1107) ng/ml hAAT, compared to the therapeutic target of 70 µg/ml in ELF, n=6 per group) (Chapter 3). 2. A lentiviral vector, pseudotyped with Sendai virus surface proteins (rSIV.F/HN-hCEF-sohAAT) resulted in therapeutic levels of hAAT in murine ELF (treated: median 70.0 (range 53.8-175.7 µg/ml, untreated: 0.19 (0.12-0.34) µg/ml, p<0.05, n=6 per group) (Chapter 5). 3. A single dose of rSIV.F/HN resulted in sustained transgene expression for at least 20 months in murine lung and ELF (p<0.05) (Chapter 5). 4. In an ex vivo assay, broncho-alveolar lavage fluid (BALF) from rSIV.F/HN-treated mice inhibited neutrophil elastase significantly more than BALF from untreated mice (p<0.05) (Chapter 7). 5. rSIV.F/HN-hCEF-sohAAT successfully transduced human lung tissue ex vivo; precision-cut human lung slices (treated: median 320 (range 207-1307) ng/ml, untreated: 9.3 (7.5-10) ng/ml, p<0.01, n=6 per group) and primary human nasal epithelial cells (treated: 389 (339-502) ng/ml, untreated: 140 (103-176) ng/ml, p<0.01, n=6 per group) (Chapter 6). In summary, data generated in this thesis supports further progression of rSIV.F/HN-hCEF-sohAAT towards a clinical trial in hAAT deficient patients.
title: Προβλήματα στη φυσική της συμπυκνωμένης ύλης
Creators: name: Giannopapas, Vasileios
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΚΡΥΣΤΑΛΛΙΚΗ ΔΟΜΗ
ΚΡΥΣΤΑΛΛΙΚΗ ΠΕΡΙΘΛΑΣΗ
ΔΥΝΑΜΙΚΗ ΠΛΕΓΜΑΤΟΣ
ΘΕΡΜΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΣΤΕΡΕΩΝ
ΗΜΙΑΓΩΓΟΙ
ΠΡΟΤΥΠΟ ΕΛΕΥΘΕΡΩΝ ΗΛΕΚΤΡΟΝΙΩΝ
ΔΟΜΗ ΕΝΕΡΓΕΙΑΚΩΝ ΖΩΝΩΝ ΗΛΕΚΤΡΟΝΙΩΝ
Crystal Structure
Diffraction In Crystals
Lattice Dynamics
Thermal Properties Of Solids
Free Electron Model
Energy Band Structure Of Electrons
Semiconductors

description: Το προτεινόμενο βιβλίο απευθύνεται σε προπτυχιακούς φοιτητές που σπουδάζουν σε τμήματα/ σχολές Φυσικής και θα περιέχει λυμένα προβλήματα της Φυσικής της Συμπυκνωμένης Ύλης (ΦΣΥ). Τέτοιου είδους βιβλίο δεν υπάρχει την ελληνική βιβλιογραφία σχετικά με τη ΦΣΥ, τουλάχιστον εξ’ όσων γνωρίζω ο ίδιος. Επίσης και σύμφωνα πάντα με τη δική μου αντίληψη, δεν υπάρχει βιβλίο στην αγγλική το οποίο περιέχει λυμένα προβλήματα στη ΦΣΥ για ένα εισαγωγικό μάθημα πάνω σε αυτό το αντικείμενο. Έτσι λοιπόν, το προτεινόμενο βιβλίο φιλοδοξεί να γίνει το πρώτο, ίσως, βιβλίο που θα επιλύει προβλήματα στη ΦΣΥ και θα λειτουργεί συμπληρωματικά ενός κύριου συγγράμματος που, παραδοσιακά, περιέχει τη σχετική θεωρία μαζί με, ως επί το πλείστον, άλυτες ασκήσεις (αν περιέχει ασκήσεις).

Λόγω της πολυπλοκότητας των προβλημάτων στη ΦΣΥ, αρκετά από τα προβλήματα δεν επιδέχονται αναλυτικής μαθηματικής λύσης και ως εκ τούτου χρήζουν μεθόδων αριθμητικής ανάλυσης. Χαρακτηριστικό παράδειγμα η εύρεση των ενεργειακών ζωνών σε μονοδιάστατο στερεό που περιγράφεται από το πρότυπο Kronig-Penney (ίσως το απλούστερο κρυσταλλικό στερεό που μπορεί να φανταστεί κανείς) η οποία απαιτεί την αριθμητική επίλυση μη γραμμικών (υπερβατικών) εξισώσεων (βλέπε σχετικό απόσπασμα από ενδεικτικό κεφάλαιο). Έτσι, λοιπόν, στο προτεινόμενο βιβλίο θα περιέχονται και προβλήματα τα οποία επιλύονται μόνο με αριθμητικές μεθόδους όπου και θα παρατίθενται οι αντίστοιχοι αλγόριθμοι – πηγαίοι κώδικες σε γλώσσα FORTRAN 90 η οποία αποτελεί την επικρατούσα γλώσσα προγραμματισμού στις φυσικές επιστήμες. Τα επιλυόμενα προβλήματα αναφέρονται στη διδακτέα ύλη που αντιστοιχεί σε ένα εισαγωγικό μάθημα στη ΦΣΥ το οποίο, επιγραμματικά, καλύπτει τα θέματα του χημικού δεσμού στα στερεά, της κρυσταλλικής δομής και περίθλασης, της δυναμικής του πλέγματος (φωνόνια), των θερμικών ιδιοτήτων, του προτύπου των ελευθέρων ηλεκτρονίων, των ενεργειακών ζωνών ηλεκτρονίων και των ημιαγωγών.
Rosmarinus officinalis Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Lamiaceae
Rosmarinus
Rosmarinus officinalis

description: Rosmarinus officinalis Linnaeus, Species Plantarum 1: 23. 1753.
"Habitat in Hispania, G. narbonensi, Galilaea." RCN: 181.
Lectotype (Hedge in Jarvis & al., Regnum Veg. 127: 82. 1993): Herb. Clifford: 14, Rosmarinus 1 α, sheet 5 (BM-000557615).
Generitype of Rosmarinus Linnaeus.
Current name: Rosmarinus officinalis L. (Lamiaceae).
Note: Siddiqi (in Jafri & El-Gadi, Fl. Libya 118: 30. 1985) and Hedge (in Ali & Nasir, Fl. Pakistan 192: 26. 1990) treated 41.2 and 41.1 (LINN) respectively as the type. However, neither sheet appears to have been present in the herbarium in 1753, and Hedge subsequently designated Clifford material as the lectotype.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 800, DOI: 10.5281/zenodo.291971
Additional file 10 of Characterization of tea (Camellia sinensis L.) flower extract and insights into its antifungal susceptibilities of Aspergillus flavus
Creators: name: Chen, Fangfang
name: Chen, Yu-Pei
name: Wu, Hongtan
name: Li, Ya
name: Zhang, Shudi
name: Ke, Jincheng
name: Yao, Jeng-Yuan
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Supplementary Material 10
MOESM3 of Development of a strictly regulated xylose-induced expression system in Streptomyces
Creators: name: Noguchi, Yuji
name: Kashiwagi, Norimasa
name: Uzura, Atsuko
name: Ogino, Chiaki
name: Kondo, Akihiko
name: Ikeda, Haruo
name: Sota, Masahiro
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 3: Figure S3. (A) Chitobiase activity and (B) optical density (600 nm) of S. lividans XCPR after 48, 72, and 96 h cultivation. After 48 h, D-xylose was added to a final concentration of 0.0, 0.5, 1.0, and 2.0%. Cultivation was continued for 24 and 48 h (72 and 96 h total).
Photometry of Proxima Centauri and Barnard's Star Using HST Fine Guidance Sensor 3: A Search for Periodic Variations
Creators: name: Benedict, G. Fritz
name: McArthur, Barbara
name: Nelan, E.
name: Story, D.
name: Whipple, A. L.
name: Shelus, P. J.
name: Jefferys, W. H.
name: Hemenway, P. D.
name: Franz, Otto G.
name: Wasserman, L. H.
name: Duncombe, R. L.
name: van Altena, Wm.
name: Fredrick, L. W.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have observed Proxima Centauri and Barnard's Star with Hubble Space Telescope Fine Guidance Sensor 3. Proxima Centauri exhibits small-amplitude, periodic photometric variations. Once several sources of systematic photometric error are corrected, we obtain 2 milli-magnitude internal photometric precision. We identify two distinct behavior modes over the past four years: higher amplitude, longer period; smaller amplitude, shorter period. Within the errors one period (P ~ 83d) is twice the other. Barnard's Star shows very weak evidence for periodicity on a timescale of approximately 130 days. If we interpret these periodic phenomena as rotational modulation of star spots, we identify three discrete spots on Proxima Cen and possibly one spot on Barnard's Star. We find that the disturbances change significantly on time scales as short as one rotation period.
description: 39 pages, 17 figures
Back and forth from Fock space to Hilbert space: a guide for commuters
Creators: name: Beggi, Andrea
name: Siloi, Ilaria
name: Benedetti, Claudia
name: Piccinini, Enrico
name: Razzoli, Luca
name: Bordone, Paolo
name: Paris, Matteo G. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum states of systems made of many identical particles, e.g. those described by Fermi-Hubbard and Bose-Hubbard models, are conveniently depicted in the Fock space. However, in order to evaluate some specific observables or to study the system dynamics, it is often more effective to employ the Hilbert space description. Moving effectively from one description to the other is thus a desirable feature, especially when a numerical approach is needed. Here we recall the construction of the Fock space for systems of indistinguishable particles, and then present a set of recipes and advices for those students and researchers in the need to commute back and forth from one description to the other. The two-particle case is discussed in some details and few guidelines for numerical implementations are given.
description: 20 pages, 4 figures
Lattice Stellar Dynamics
Creators: name: Syer, D.
name: Tremaine, S.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We describe a technique for solving the combined collisionless Boltzmann and Poisson equations in a discretised, or lattice, phase space. The time and the positions and velocities of `particles' take on integer values, and the forces are rounded to the nearest integer. The equations of motion are symplectic. In the limit of high resolution, the lattice equations become the usual integro-differential equations of stellar dynamics. The technique complements other tools for solving those equations approximately, such as $N$-body simulation, or techniques based on phase-space grids. Equilibria are found in a variety of shapes and sizes. They are true equilibria in the sense that they do not evolve with time, even slowly, unlike existing $N$-body approximations to stellar systems, which are subject to two-body relaxation. They can also be `tailor-made' in the sense that the mass distribution is constrained to be close to some pre-specified function. Their principal limitation is the amount of memory required to store the lattice, which in practice restricts the technique to modeling systems with a high degree of symmetry. We also develop a method for analysing the linear stability of collisionless systems, based on lattice equilibria as an unperturbed model.
description: Accepted for publication in Monthly Notices. 18 pages, compressed PostScript, also available from http://www.cita.utoronto.ca/~syer/papers/
Reminiscences of Wendell Castle 1985
Publisher: name: Columbia University
Year: 2019
Subjects: Woodworkers
Woodwork
Furniture making
Wood-carving
Laminated wood

description: Childhood; education at University of Kansas; United States Army, West Germany, 1954; teaching at School for American Craftsmen, Rochester, N.Y., 1962-1970 and at University at Brockport, 1970-1980; founding and directing of Woodworking School, Rochester, N.Y., 1980- , trends in his work: stack and strip lamination, trompe l'oeil carving, traditional forms.
Additional file 11 of Characterization of tea (Camellia sinensis L.) flower extract and insights into its antifungal susceptibilities of Aspergillus flavus
Creators: name: Chen, Fangfang
name: Chen, Yu-Pei
name: Wu, Hongtan
name: Li, Ya
name: Zhang, Shudi
name: Ke, Jincheng
name: Yao, Jeng-Yuan
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Supplementary Material 11
On Lennard-Jones-type potentials on the half-line
Creators: name: Gregorio, Federica
name: Kerner, Joachim
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81Q10, 81Q37, 81Q80, 81Q35, 47E05, 47D08

description: In this paper we study a particle under the influence of a Lennard-Jones potential moving in a simple quantum wire modelled by the positive half-line. Despite its physical significance, this potential is only rarely studied in the literature and due to its singularity at the origin it cannot be considered as a standard perturbation of the one-dimensional Laplacian. It is therefore our aim to provide a thorough description of the Hamiltonian in one dimension via the construction of a suitable quadratic form. Our results include a discussion of spectral and scattering properties which finally allows us to generalise some results from [Robinson1974] as well as [RadinSimon1978].
description: various typos corrected; to appear in Archiv der Mathematik
Additional file 2: of Methods for conducting a double-blind randomized controlled clinical trial of three days versus five days of amoxicillin dispersible tablets for chest indrawing childhood pneumonia among children two to 59Â months of age in Lilongwe, Malawi: a study protocol
Creators: name: Ginsburg, Amy
name: May, Susanne
name: Evangelyn Nkwopara
name: Ambler, Gwen
name: McCollum, Eric
name: Tisungane Mvalo
name: Ajib Phiri
name: Lufesi, Norman
name: Sadruddin, Salim
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Appendix 1. Informed consent form for enrollment. (DOC 67 kb)
A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Prioritization under TSCA
Creators: name: EPA, Admin
Publisher: name: The United States Environmental Protection Agency’s Center for Computational Toxicology and Exposure
Year: 2021
Subjects: Toxicology

description: Regulatory agencies world-wide are looking to efficiently integrate information on chemical substances in order to inform priorities for decisions and data requests. This document updates the long-term strategy described in the Working Approach and presents the Public Information Curation and Synthesis (PICS) approach that integrates publicly-available hazard, exposure, persistence, and bioaccumulation information for chemical substances. This approach is not designed to replace the prioritization process described in TSCA but aims to increase efficiency and focus expert review on substances that may have a greater potential for selection as a high- or low-priority candidate.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 0181v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0181v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0181v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Reminiscences of Wendy Maruyama 1991
Publisher: name: Columbia University
Year: 2019
Subjects: Women woodworkers
Deaf--Education
Woodwork--Study and teaching
Furniture making
Handicraft--Prices
Arts and crafts movement

description: Childhood in San Diego, California: reflections on being deaf and going to school, limits on interaction with other people; early interest in art; education at junior college and San Diego State University; early influences in her life; decision to go into woodworking; education at Virginia Commonwealth University, and Boston University, and Rochester Institute of Technology: discussion of the technical and creative aspects of her education; first job in Vail, Colorado, and at the Appalachian Center for Crafts in Tennessee; description of early work and production in Tennessee: combination of materials and collaborative work; discussion of the pricing of art; problems in the relationship of the Appalachian Center to local community; move to the San Francisco Bay area: orientation towards larger scale production of furniture; professorship at San Diego State University in 1989; reflections on teaching in graduate school; reflections on appropriating artistic styles from other cultures; discussion of being a woman in the woodworking field.
title: 02_0340
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/