cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
Creators: name: Sali, Andrej
name: Schlessinger, Avner
name: Shoichet, Brian K
name: Fan, Hao
name: Carlsson, Jens
name: Irwin, John J
name: Coleman, Ryan G
name: Roth, Bryan L
name: Setola, Vincent
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: G-Protein coupled receptors (GPCRs) are intensely studied as drug targets and for their role in signaling. With the determination of the first crystal structures, interest in structure-based ligand discovery has increased. Unfortunately, most GPCRs lack experimental structures. The determination of the D3 receptor structure, and a community challenge to predict it, enabled a fully prospective comparison of ligand discovery from a modeled structure versus that of the subsequently released crystal structure. Over 3.3 million molecules were docked against a homology model, and 26 of the highest ranking were tested for binding. Six had affinities from 0.2 to 3.1μM. Subsequently, the crystal structure was released and the docking screen repeated. Of the 25 compounds selected, five had affinities from 0.3 to 3.0μM. One of the novel ligands from the homology model screen was optimized for affinity to 81nM. The feasibility of docking screens against modeled GPCRs more generally is considered.
AGINFRA PLUS D2.3 - Data Linking Technologies
Creators: name: Stoitsis, Giannis
name: Katsivelis, Panagis
Publisher: name: Zenodo
Year: 2020
Subjects: living document; semantically data assets; data linking platform; heterogeneous data

description: The present report is the last submitted iteration of a living document that describes progress and evolvement of the AGINFRA PLUS data linking technologies, i.e. the services and software components that were incorporated in the overall AGINFRA PLUS e-infrastructure and were responsible for providing data and relevant links to project use-cases. As the project activities progressed, the efforts pertaining to data linking activities were generalized to define a set of services designed to bring domain-relevant data under a common repository: the AGINFRA Data Registry. The Registry was aligned with the AGINFRA Registry of Semantic Resources to enable better annotation of data assets, but also increased discoverability via semantic expansion of user queries.
 The final version of the deliverable focuses on the description of the core services enabling the AGINFRA Data Registry and its surrounding family of services, namely the Data Harvesting and Data Linking services.
OAHP Historic Structure Inventory, Fort Sam Houston Landmark District and Camp Bullis, Texas
Creators: name: Tompkins, Sally Kress
Publisher: name: Office of Archeology and Historic Preservation, Department of the Interior
Year: 1980
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Fort Sam Houston National Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/82955/fort-sam-houston-national-historic-landmark-district
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A group of historic structure inventory forms and photographs for Fort Sam Houston, Joint Base San Antonio, Texas. These are general information cards regarding the inventory project.
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
Creators: name: Zhang, Yi
name: Shen, Li
name: Ye, Yu
name: Goldschmidt, Hana L
name: Kohli, Rahul M
name: Jia, Huijue
name: Nabel, Christopher S
name: Stivers, James T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: AID/APOBEC family cytosine deaminases, known to function in diverse cellular processes from antibody diversification to mRNA editing, have also been implicated in DNA demethylation, an important process for transcriptional activation. While oxidation-dependent pathways for demethylation have been described, pathways involving deamination of either 5-methylcytosine (mC) or 5-hydroxymethylcytosine (hmC) have emerged as alternatives. Here, we have addressed the biochemical plausibility of deamination-coupled demethylation. We found that purified AID/APOBECs have substantially reduced activity on mC relative to cytosine, their canonical substrate, and no detectable deamination of hmC. This finding was explained by the reactivity of a series of modified substrates, where steric bulk was increasingly detrimental to deamination. Further, upon AID/APOBEC overexpression, the deamination product of hmC was undetectable in genomic DNA, while oxidation intermediates remained detectable. Our results indicate that the steric requirements for cytosine deamination are one intrinsic barrier to the proposed function of deaminases in DNA demethylation.
Charged Renyi entropies and holographic superconductors
Creators: name: Belin, Alexandre
name: Hung, Ling-Yan
name: Maloney, Alexander
name: Matsuura, Shunji
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Other Condensed Matter (cond-mat.other)
subject: Superconductivity (cond-mat.supr-con)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Charged Renyi entropies were recently introduced as a measure of entanglement between different charge sectors of a theory. We investigate the phase structure of charged Renyi entropies for CFTs with a light, charged scalar operator. The charged Renyi entropies are calculated holographically via areas of charged hyperbolic black holes. These black holes can become unstable to the formation of scalar hair at sufficiently low temperature; this is the holographic superconducting instability in hyperbolic space. This implies that the Renyi entropies can be non-analytic in the Renyi parameter n. We find the onset of this instability as a function of the charge and dimension of the scalar operator. We also comment on the relation between the phase structure of these entropies and the phase structure of a holographic superconductor in flat space.
description: 21 pages, 6 figures
Chemical informatics and target identification in a zebrafish phenotypic screen
Creators: name: Keiser, Michael J
name: Lin, Henry
name: Laggner, Christian
name: Roth, Bryan L
name: Setola, Vincent
name: Kokel, David
name: Minor, Daniel L
name: Irwin, John J
name: Tolia, Alexandra
name: Peterson, Randall T
name: Shoichet, Brian K
name: Cheung, Chung Yan J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Target identification is a core challenge in chemical genetics. Here we use chemical similarity to predict computationally the targets of 586 compounds active in a zebrafish behavioral assay. Of 20 predictions tested, 11 had activities ranging from 1 to 10,000nM on the predicted targets. The role of two of these targets was tested in the original zebrafish phenotype. Prediction of targets from chemotype is rapid and may be generally applicable.
Evidence for dynamics in proteins as a mechanism for ligand dissociation
Creators: name: Gromova, Anna V
name: Collins, Edward J
name: Carroll, Mary J
name: Singleton, Scott F
name: Lee, Andrew L
name: Mauldin, Randall V
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Signal transduction, regulatory processes, and pharmaceutical responses are highly dependent upon ligand residence times. Gaining insight into how physical factors influence residence times, or koff, should enhance our ability to manipulate biological interactions. We report experiments that yield structural insight into koff for a series of eight 2,4-diaminopyrimidine inhibitors of dihydrofolate reductase that vary by six orders of magnitude in binding affinity. NMR relaxation dispersion experiments revealed a common set of residues near the binding site that undergo a concerted, millisecond-timescale switching event to a previously unidentified conformation. The rate of switching from ground to excited conformations correlates exponentially with Ki and koff, suggesting that protein dynamics serves as a mechanical initiator of ligand dissociation within this series and potentially for other macromolecule-ligand systems. Although kconf,forward is faster than koff, use of the ligand series allowed for connections to be drawn between kinetic events on different timescales.
Response from Stan Graves to Richard Strimel, Beach Pavilion Building 2376, Fort Sam Houston, Texas
Creators: name: Graves, Stanley O.
name: Jimenez, Demetrio
Publisher: name: Texas Historical Commission
Year: 1992
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Beach Pavilion
valueUri: https://core.tdar.org/browse/other-keyword/156800/beach-pavilion
subject: Building 2376
valueUri: https://core.tdar.org/browse/other-keyword/152909/building-2376
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Texas Historical Commission has received and reviewed Fort Sam Houston's project proposal to the Beach Pavilion Building 2376 and has determined "no adverse effect" to the historic building. Carbon copied to this letter is Mike Hilger.
A Randomized Controlled Trial on Short-term Therapeutic Effects of Thai HerbalCompresses versus Warm Placebo Compresses on Myogenous Temporomandibular Disorder Pain
Creators: name: Siriporn Chaimano
Publisher: name: Faculty of Dentistry, Chiang Mai University
Year: 2021
Subjects: herbal
myogenous pain
randomized clinical trials
temporomandibular disorders
Thai herbal compress

description: Chiang Mai Dental Journal, 42, 2, 114-119
Syntheses of calix[4]pyrrole–based receptors and applications for therapeutics and environmental remediation
Creators: name: Hwang, Inhong
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Calix[4]pyrroles
Therapeutics
Environmental remediation
Anion transport
Extraction of hydroxide

description: Significant efforts have been made to develop synthetic receptors with high selectivity and affinity for specific anions or ion pairs. Calix[4]pyrroles, conformationally flexible tetrapyrrolic macrocycles defined by sp³ hybridized meso bridges, have emerged as one of the essential supramolecular hosts for anion and ion pair recognition. This dissertation describes efforts to develop functional calix[4]pyrroles that might allow their eventual use as therapeutics and in environmental remediation applications. A series of calix[4]pyrroles were prepared by functionalizing the parent calix[4]pyrrole at the so–called meso bridges, including mono–walled calix[4]pyrroles, double–walled calix[4]pyrroles, and strapped calix[4]pyrroles. Chapter 1 provides a brief overview of calix[4]pyrroles, calix[4]pyrrole–based anion transporters, and hydroxide extraction based on host–guest chemistry. Chapter 2 summarizes synthetic developments focused on preparing new calix[4]pyrroles. Chapter 3 details studies devoted to establishing correlations between changes in intracellular cation concentrations and cancer cell death. Chapter 4 describes the recognition and extraction of sodium hydroxide using calix[4]pyrrole–based ion pair receptors. Chapter 5 provides the synthetic procedures and the characterization data for all new compounds used in these studies.
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1990
Subjects: Community/Rural/Urban Development

description: Overview: Arrival of Recession Raises Questions About Rural Effect; National Economic Conditions: Recession Talk Dominates Macroeconomic Scene; Employment: Rural Employment Declines; Unemployment: Rural Unemployment Remains Steady; Population: Preliminary 1990 Census Counts Confirm Drop in Nonmetro Population Growth; Appendix: Data Sources and Definitions; Appendix Tables
AGINFRA PLUS D4.2 - Scientific Workflow Design Technologies
Creators: name: Katsivelis, Panagis
name: Papakonstantinou, Michail
name: Stoitsis, Giannis
Publisher: name: Zenodo
Year: 2020
Subjects: workflow design components; living document; workflow management platform

description: The present deliverable is the last submitted iteration of the demonstrators and accompanying reports that describe progress and evolvement of the AGINFRA+ workflow design components, i.e. the software components that will be incorporated in the overall AGINFRA+ architecture and will allow the management and execution of scientific workflows. The current version of the deliverable provides a summary of the workflow management platforms that are used in the context of the project, and the steps carried out for making them available to the user communities involved in AGINFRA+. The incorporated software components are three major workflow management systems, used directly by scientific communities or as part of the proposed AGINFRA+ data e-infrastructure. The aforementioned developments will be made directly available via updates on the deliverable’spublic Wiki space, hosted within the AGINFRA+ gateway (https://aginfra.d4science.org/). The wiki can be accessed at: https://support.d4science.org/projects/aginfraplus_wiki/wiki/D42_-_Scientific_Workflow_Design_Technologies
A systematic study of magnetic field in Relativistic Heavy-ion Collisions in the RHIC and LHC energy regions
Creators: name: Zhong, Yang
name: Yang, Chunbin
name: Cai, Xu
name: Feng, Shengqin
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The features of magnetic field in relativistic heavy-ion collisions are systematically studied by using a modified magnetic field model in this paper. The features of magnetic field distributions in the central point are studied in the RHIC and LHC energy regions. We also predict the feature of magnetic fields at LHC $\sqrt{s_{NN}}$= 900, 2760 and 7000 GeV based on the detailed study at RHIC $\sqrt{s_{NN}}$ = 62.4, 130 and 200 GeV. The dependencies of the features of magnetic fields on the collision energies, centralities and collision time are systematically investigated, respectively.
description: 8 pages, 7 figures
Reconnaissance limnology of Tasmania VII. Coastal lagoons of Bass Strait Islands, with reference to endemic microflora and microfauna
Creators: name: Walsh, R. G. J
name: Shiel, R. J
name: Tyler, P. A
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Coastal lagoons of the principal islands of Bass Strait, between Australia's mainland and Tasmania, were sampled in two summers. Many, particularly those of low to moderate salinity, contain relatively rich assemblages of microinvertebrates and some endemic Australian freshwater algae. Several species of testate amoebae and rotifers could not be referred to known morphotypes and are probably new species. The presence of certain species on islands of Bass Strait provides a link between populations in mainland Australia and others in Tasmania. Those lagoons are identified that, by virtue of catchments or buffer zones clothed in native vegetation, are favourable for the survival of a native and partly endemic microbiota.
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo
Creators: name: Coelho, Pedro S
name: Arnold, Frances H
name: Ener, Maraia E
name: Brustad, Eric M
name: Wang, Z Jane
name: Baril, Stefanie A
name: Kannan, Arvind
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Genetically encoded catalysts for non-natural chemical reactions will open new routes to sustainable production of chemicals. We designed a unique serine-heme ligated cytochrome “P411” that catalyzes efficient and selective carbene transfers from diazoesters to olefins in intact Escherichia coli cells. The mutation C400S in cytochrome P450BM3 gives a signature ferrous-CO Soret peak at 411 nm, abolishes monooxygenation activity, raises the resting state FeIII/II reduction potential, and significantly improves NAD(P)H-driven cyclopropanation activity.
Building 100 Taj Mahal, Correspondence Packet, 1987 Undertakings, Randolph Air Force Base, Texas
Creators: name: Shull, Carol D.
Publisher: name: United States Department of the Interior, National Park Service
Year: 1987
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Taj Mahal
valueUri: https://core.tdar.org/browse/other-keyword/153391/taj-mahal
subject: Rotunda
valueUri: https://core.tdar.org/browse/other-keyword/158237/rotunda
subject: Building 100
valueUri: https://core.tdar.org/browse/other-keyword/153390/building-100
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This is a packet of correspondence concerning Building 100, known as the Taj Mahal at Randolph Air Force Base, Texas. Included is a telephone report and typed letter addressing the repair/replacement of doors for Building 100, as well as a letter from the National Register of Historic Places stating the placement of the Building in the National Register of Historic Places.
Schütz-Jahrbuch, Bd. 1 (1979)
Creators: name: Schütz-Jahrbuch
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Enthält Freie Beiträge zu verschiedenen Themengebieten.
description: Titelseite Resümees der Beiträge (englisch, französisch, schwedisch)...143-146 Instrumentalität und Sprachvertonung in der Musik von Heinrich Schütz...9-43 Impressum Schützens Italienische Madrigale: Textwahl und stilistische Beziehungen...44-62 Anzeigen Internationale Heinrich-Schütz-Gesellschaft e.V. Schützfunde und -zuschreibungen seit 1960. Auf dem Wege zur Großen Ausgabe des Schütz-Werke-Verzeichnisses...63-92 Inhalt Bibliographie des Schütz-Schrifttums 1951-1975...93-142 Geleitwort...5-7
Supersymmetric Analysis of the Dirac-Weyl Operator within PT Symmetry
Creators: name: Yeşiltaş, Özlem
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Two dimensional effective Hamiltonian for a massless Dirac electron interacting with a hyperbolic magnetic field is discussed within PT symmetry. Factorization method and polynomial procedures are used to solve Dirac equation for the constant Fermi velocity and the effective potential which is complex Scarf II potential. The more general effective Scarf II potential models are also obtained within pseudo-supersymmetry. Finally, an extension of Panella and Roy's work [12] to the both PT symmetric and real Scarf II partner potentials are given using the position dependent Fermi velocity.
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
Creators: name: Duan, Shili
name: MacNevin, Christopher J
name: Frye, Stephen V
name: Janzen, William P
name: Barsyte-Lovejoy, Dalia
name: Huang, Xi-Ping
name: Korboukh, Victoria K
name: Norris, Jacqueline L
name: Greenblatt, Jack F
name: Emili, Andrew
name: Herold, J Martin
name: Jin, Jian
name: Guo, Hongbo
name: Brown, Peter J
name: Krichevsky, Liubov
name: Arrowsmith, Cheryl H
name: James, Lindsey I
name: Zhong, Nan
name: Marcon, Edyta
name: Gao, Cen
name: Bedford, Mark T
name: Sagum, Cari A
name: Kireev, Dmitri B
name: Tempel, Wolfram
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We describe the discovery of UNC1215, a potent and selective chemical probe for the methyl-lysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. UNC1215 binds L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containing peptides, and is greater than 50-fold selective versus other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a novel 2:2 polyvalent mode of interaction. In cells, UNC1215 is non-toxic and binds directly to L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins and point mutants that disrupt the Kme binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215. Finally, UNC1215 demonstrates a novel Kme-dependent interaction of L3MBTL3 with BCLAF1, a protein implicated in DNA damage repair and apoptosis.
Three-dimensional Boltzmann-Hydro code for core-collapse in massive stars I. special relativistic treatments
Creators: name: Nagakura, Hiroki
name: Sumiyoshi, Kohsuke
name: Yamada, Shoichi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We propose a novel numerical method for solving multi-dimensional, special relativistic Boltzmann equations for neutrinos coupled to hydrodynamics equations. It is meant to be applied to simulations of core-collapse supernovae. We handle special relativity in a non-conventional way, taking account of all orders of v/c. Consistent treatment of advection and collision terms in the Boltzmann equations is the source of difficulties, which we overcome by employing two different energy grids: Lagrangian remapped and laboratory fixed grids. We conduct a series of basic tests and perform a one-dimensional simulation of core-collapse, bounce and shock-stall for a 15M_{sun} progenitor model with a minimum but essential set of microphysics. We demonstrate in the latter simulation that our new code is capable of handling all phases in core-collapse supernova. For comparison, a non-relativistic simulation is also conducted with the same code, and we show that they produce qualitatively wrong results in neutrino transfer. Finally, we discuss a possible incorporation of general relativistic effects in our method.
description: 25 pages, 22 figures, submitted to ApJ
Letter from Joseph Logan to Curtis Tunnell, Rehabilitation of Rest Room Building 235, Randolph Air Force Base, Texas
Creators: name: Logan, Joseph M.
Publisher: name: Department of the Air Force, Randolph Air Force Base
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Building 235
valueUri: https://core.tdar.org/browse/other-keyword/158252/building-235
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Summary documentation produced for review concerning a proposed rehabilitation of the rest room at Building 235, Randolph Air Force Base, Texas. Attachments are included. This letter is part of a packet of correspondence addressing a proposed undertaking to rehabilitate the rest room at Building 235, Randolph Air Force Base, Texas. Included is a summary letter of the extent of the project, location maps, historic data, and photographs.
Molecular mechanisms of TFF1-Helicobacter cross-talk
Creators: name: Mentucci, Fatima Maria
Publisher: name: Universita degli studi di Salerno
Year: 2023
Subjects: subject: BIO/11 BIOLOGIA MOLECOLARE
subject: Helicobacter pylori
subject: Gatric cancer
subject: TFF1

description: 2021 - 2022
description: Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it could lead to chronic infection and eventually, in a subset of individuals, to gastric cancer. In response to the infection, the gastric mucosa releases several protective factors, including TFF1, which binds Helicobacter in the mucus layer and reduces inflammation caused by the infection. TFF1 is a gastro-specific tumor suppressor gene upregulated in the acute phase of the Helicobacter infection but silenced during the chronic infection. This Ph.D. thesis project aimed to evaluate the role of TFF1 in the context of infection. First, TFF1 was assayed for its effects on Helicobacter at molecular and morphological levels. The results showed that H. pylori is more prone to aggregate in a TFF1- concentration-dependent manner and as consequence its motility through a physiological mucus layer is compromised. Since Helicobacter chronic infection promotes TFF1 silencing impairing the mucosal protection and contributing to the development of malignant transformation, the second aim of this thesis was to investigate the molecular pathways involved in this silencing. Our hypothesis was that the cytokines secreted by activated immune cells during H. pylori chronic infection would cause the silencing of TFF1 in gastric cells. Based on our results, IFNγ plays the major role in the TFF1 downregulation. Moreover, examining the TFF1 promoter, this phenotype seems to occur via C/EBPβ that works as a negative regulator during IFNγ stimulation. According to our evidence, IFNγ induces the expression of C/EBPβ and favors its binding to the TFF1 promoter, repressing its transcription. In addition, the involvement of DNA methylation in this process was evaluated, suggesting that this epigenetic mechanism is also involved in IFNγ-dependent TFF1 silencing. [edited by Author]
Artifact reduction in multichannel pervasive EEG using hybrid WPT-ICA and WPT-EMD signal decomposition techniques
Creators: name: Bono, Valentina
name: Jamal, Wasifa
name: Das, Saptarshi
name: Maharatna, Koushik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Medical Physics (physics.med-ph)
subject: Machine Learning (cs.LG)
subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In order to reduce the muscle artifacts in multi-channel pervasive Electroencephalogram (EEG) signals, we here propose and compare two hybrid algorithms by combining the concept of wavelet packet transform (WPT), empirical mode decomposition (EMD) and Independent Component Analysis (ICA). The signal cleaning performances of WPT-EMD and WPT-ICA algorithms have been compared using a signal-to-noise ratio (SNR)-like criterion for artifacts. The algorithms have been tested on multiple trials of four different artifact cases viz. eye-blinking and muscle artifacts including left and right hand movement and head-shaking.
description: 5 pages, 6 figures
Letter from Emmitt Smith to Curtis Tunnell, Door Top and Entrance Protection, Randolph Air Force Base, Texas
Creators: name: Smith, Emmitt G.
Publisher: name: Randolph Air Force Base
Year: 1994
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Randolph Air Force Base is considering an undertaking that may effect buildings that are eligible for listing on the National Register of Historic Places. It has been determined that the installation of door top and entrance protection to these buildings will have no effect on the property. Included is a description of the undertaking.
Afghanistanâ€™s mineral fortune: prospects for fuelling a green transition?
Creators: name: Hale, Thomas N.
name: Ali, Saleem H.
Publisher: name: Geological Society of London
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Summary table of areas of interest (S1), maps showing mineral production potential, water depletion, earthquake occurrences in Afghanistan, levels of exposure to droughts, floods and landslides and food insecurity (S2–S6)
Moment problem in infinitely many variables
Creators: name: Ghasemi, Mehdi
name: Kuhlmann, Salma
name: Marshall, Murray
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 44A60, 14P99

description: The multivariate moment problem is investigated in the general context of the polynomial algebra $\mathbb{R}[x_i \mid i \in Ω]$ in an arbitrary number of variables $x_i$, $i\in Ω$. The results obtained are sharpest when the index set $Ω$ is countable. Extensions of Haviland's theorem [Amer. J. Math., 58 (1936) 164-168] and Nussbaum's theorem [Ark. Math., 6 (1965) 179-191] are proved. Lasserre's description of the support of the measure in terms of the non-negativity of the linear functional on a quadratic module of $\mathbb{R}[x_i \mid i \in Ω]$ in [Trans. Amer. Math. Soc., 365 (2013) 2489-2504] is shown to remain valid in this more general situation. The main tool used in the paper is an extension of the localization method developed by the third author.
Schütz-Jahrbuch, Bd. 2 (1980)
Creators: name: Schütz-Jahrbuch
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Enthält Freie Beiträge zu verschiedenen Themengebieten.
description: Titelseite Resümees der Beiträge (englisch, französisch, schwedisch)...131-136 Stylus phantasticus und phantastische Musik : kompositorische Verfahren in Toccaten von Frescobaldi und Buxtehude...7-77 Impressum Heinrich Schütz - die historische Begegnung der deutschen Sprache mit der musikalischen Poetik Italiens...78-102 Anzeigen Inhalt Tonartenprobleme in den Passionen von Schütz...103-119 Theatralische neue Vorstellung von der Maria Magdalena - Ein Zeugnis für die Zusammenarbeit von Justus Georg Schottelius und Heinrich Schütz...120-130
Schütz-Jahrbuch, Bd. 3 (1981)
Creators: name: Schütz-Jahrbuch
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Enthält die Beiträge zum Kolloquium "Aspekte der Mehrchörigkeit" der Internationalen Heinrich-Schütz-Gesellschaft Kassel 1980.
description: Titelseite Theologische Konzeptionen in mehrchöriger Musik...7-11 Resümees der Beiträge (englisch, französisch, schwedisch) / Berichtigung...82-88 Impressum Rhythmus, Sprache, musikalische Raumvorstellung. Zur Mehrchörigkeit Giovanni Gabrielis...12-23 Anzeigen Inhalt Mehrchörigkeit und individuelle Werkkonzepzionen bei Heinrich Schütz...24-38 Mehrchörigkeit und thematischer Satz bei Johann Sebastian Bach...39-50 Sprachvertonung bei Heinrich Schütz als analytisches Problem...51-63 Bibliographie des Schütz-Schrifttums 1926-1950...64-81
Structure and functional analysis of the microbial community in an aerobic: anaerobic sequencing batch reactor (SBR) with no Phosphorus removal
Creators: name: Kong, Yun H
name: Beer, Michael
name: Seviour, Robert J
name: Lindrea, Kenneth C
name: Rees, Gavin N
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The bacterial community of an aerobic:anaerobic non-P removing SBR biomass fed a mixture of acetateand glucose was analysed using several 16S rRNA based methods. Populations responsible for anaerobicglucose and acetate assimilation were determined with fluorescent in situ hybridization (FISH) in combinationwith microautoradiography (FISH/MAR). At ‘steady state’ this community consisted of α-Proteobacteria(26%) and γ-Proteobacteria (14%), mainly appearing as large cocci in tetrads (i.e. typical ‘GBacteria’).Large numbers of low G+C bacteria (22%), and high G+C Gram-positive bacteria (29%) seenas small cocci in clusters or in sheets were also detected after FISH. DGGE fingerprinting of PCR amplified16S rDNA fragments and subsequent cloning and sequencing of several of the major bands led tothe identification of some of these populations. They included an organism 98% similar in its 16S rRNAsequence to Micropruina glycogenica, and ca. 76% of the high G+C bacteria responded to a probe MIC184, designed against it. The rest responded to the KSB 531 probe designed against a high G+C clone sequence,sbr-gs28 reported in other similar systems. FISH analyses showed that both these high G+C populationswere almost totally dominated by small clustered cocci. Only ca. 2% of cells were β-Proteobacteria.None of the α- and γ-Proteobacterial ‘G-bacteria’ responded to FISH probes designed for the ‘GBacteria’Amaricoccus spp. or Defluvicoccus vanus. FISH/MAR revealed that not all the α-Proteobacterial‘G-Bacteria’ could take up acetate or glucose anaerobically. Almost all of the γ-Proteobacterial ‘G-Bacteria’assimilated acetate anaerobically but not glucose, the low G+C clustered cocci only took up glucose,whereas the high G+C bacteria including M. glycogenica and the sbr-gs28 clone assimilated both acetateand glucose. All bacteria other than the low G+C small cocci and a few of the α-Proteobacteria accumulatedPHB. The low G+C bacteria showing anaerobic glucose assimilation ability were considered responsiblefor the lactic acid produced anaerobically by this SBR biomass, and M. glycogenica for its highglycogen content.
Using Lightweight Activity Diagrams for Modeling and Generation of Web Information Systems
Creators: name: Reiß, Dirk
name: Rumpe, Bernhard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The development process of web information systems nowadays improved a lot regarding effectiveness and tool support, but still contains many redundant steps for similar tasks. In order to overcome this, we use a model-driven approach to specify a web information system in an agile way and generate a full- edged and runnable application from a set of models. The covered aspects of the system comprise data structure, page structure including view on data, page- and workflow within the system as well as overall application structure and user rights management. Appropriate tooling allows transforming these models to complete systems and thus gives us opportunity for a lightweight development process based on models. In this paper, we describe how we approach the page- and workflow aspect by using activity diagrams as part of the agile modeling approach MontiWIS. We give an overview of the defined syntax, describe the supported forms of action contents and finally explain how the behavior is realized in the generated application.
description: 12 pages, 6 figures
Schütz-Jahrbuch, Bd. 4 (1983)
Creators: name: Schütz-Jahrbuch
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Doppeljahrgang 1982/83. Enthält die Beiträge zum dreiteiligen Symposium des 27. Internationalen Heinrich-Schütz-Festes Karlsruhe 1981.
description: Titelseite Das wiedergefundene Opus ultimum von Heinrich Schütz. Bemerkungen zur Quelle und zum Werk...9-18 Sprachauslegung und Instrumentalität in der Musik von Schütz. Mit einem Exkurs zur „Figurenlehre“...39-49 Fragen zu Mahlers VIII. Symphonie...71-72 Resümees der Beiträge (deutsch, englisch, italienisch, französisch, schwedisch)...105-113 Impressum A new look at the sources of Schütz's Christmas history...19-36 Musik als Zeugnis der Auslegungsgeschichte. Heinrich Schützens Motette Die mit Tränen säen aus der Geistlichen Chormusik...50-56 Die Idee der absoluten Musik als ihr (ausgesprochenes) Programm. Zum unterlegten Text der Mahlerschen Achten...73-91 Inhalt Heinrich Schütz als Komponist evangelischer Kirchenliedtexte...57-67 Mahlers Hymnus...92-96 Zu Mahlers Komposition der Schluss-Szene von Goethes Faust...97-102
Spin-Flop Phenomenon of Two-Dimensional Frustrated Antiferromagnets without Anisotropy in Spin Space
Creators: name: Nakano, Hiroki
name: Sakai, Toru
name: Hasegawa, Yasumasa
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Motivated by a recent finding of a spin-flop phenomenon in a system without anisotropy in spin space reported in the S=1/2 Heisenberg antiferromagnet on the square-kagome lattice, we study the S=1/2 Heisenberg antiferromagnets on two other lattices composed of vertex-sharing triangles by the numerical diagonalization method. One is a novel lattice including a shuriken shape with four teeth; the other is the kagome lattice with $\sqrt{3}\times\sqrt{3}$-structure distortion, which includes a shuriken shape with six teeth. We find in the magnetization processes of these systems that a magnetization jump accompanied by a spin-flop phenomenon occurs at the higher-field-side edge of the magnetization plateau at one-third the height of saturation. This finding indicates that the spin-flop phenomenon found in the isotropic system on the square-kagome lattice is not an exceptional case.
description: 7 pages, 7 figures, to be published in J. Phys. Soc. Jpn
Schütz-Jahrbuch, Bd. 6 (1984)
Creators: name: Schütz-Jahrbuch
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Enthält Freie Beiträge zu verschiedenen Themen.
description: Titelseite Neue Schütz-Funde in der Ratsschulbibliothek und im Stadtarchiv Zwickau...5-22 Resümees der Beiträge (englisch, italienisch, französisch, schwedisch)...127-138 Impressum Ein unbekanntes weltliches Madrigal von Heinrich Schütz: Gelegenheit und Gelegenheitsgedicht, erwogen aus germanistischer Sicht...23-51 Anzeigen Inhalt Schütz' Osterkonzert Christ ist erstanden SWV 470, seine Kasseler Ersatz-Symphonia und Hammerschmidts Dialogi von 1645...52-61 Zur Bedeutung der Andachtstexte im Werk von Heinrich Schütz...62-71 Der Gesang der Venuskinder von Heinrich Schütz: Bemerkungen zur Uberlieferung und zu den Kopenhagener Hochzeitsfeierlichkeiten im Oktober 1634...72-92 'Wie die Sonne unter den Planeten in der Mitte leuchtet, so die Musik unter den freien Künsten': Zu Heinrich Schütz' Eintragung in das Stammbuch des Andreas Möring...93-101 Bibliographie des Schütz-Schrifttums 1672-1925...102-126
Schütz-Jahrbuch, Bd. 7 (1986)
Creators: name: Schütz-Jahrbuch
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Doppeljahrgang 1985/86. Enthält Freie Beiträge zu verschiedenen Themen.
description: Titelseite Musik und Rhetorik im Barock...5-21 Resümees der Beiträge (deutsch, englisch, italienisch, französisch, schwedisch)...147-159 Impressum Die erste Fassung des Beckerschen Psalters von Heinrich Schütz...22-49 Anzeigen Inhalt Zum gegenwärtigen Stand der Schütz-Ikonographie...50-61 Schütz - Schubert - Hugo Wolf...62-68 Schütz als Kompostitionslehrer : Die 'Geistliche Madrigale' (1619) von Gabriel Mölich...69-92 From Renaissance 'Fuga' to Baroque fugue : the role of the 'Sweelinck theory manuscripts'...93-104 Christopher-Thomas Walliser (1568-1648) - musicien strasbourgeois à redécouvrir...105-123 Zwei Stücke aus Claudio Monteverdis 6. Madrigalbuch in handschriftlichen Frühfassungen...124-136 Die norddeutsche Orgeltoccata und die 'höchsten Formen der Instrumentalmusik' : Beobachtungen an der großen e-moll-Toccata von Nicolaus Bruhns...137-146
Global profiling of stimulus-induced polyadenylation in cells using a poly(A) trap
Creators: name: Singh, Irtisha
name: Cohen, Michael
name: Leslie, Christina S
name: Jaffrey, Samie R
name: Curanovic, Dusica
name: Slagle, Christopher E
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Polyadenylation of mRNA leads to increased protein expression in response to diverse stimuli, but it is difficult to identify mRNAs that become polyadenylated in living cells. Here we describe a click chemistry-compatible nucleoside analog that is selectively incorporated into poly(A) tails of transcripts in cells. Next-generation sequencing of labeled mRNAs enables a transcriptome-wide profile of polyadenylation and provides insights into the mRNA sequence elements that are correlated with polyadenylation.
Photochemical activation of TRPA1 channels in neurons and animals
Creators: name: Huang, Liyi
name: Peterson, Randall T
name: Mills, Robert
name: Coutinho-Budd, Jaeda
name: Woolf, Clifford J
name: Sprague, Jared
name: Roth, Bryan L
name: Setola, Vincent
name: Bruni, Giancarlo
name: Huang, Xi-Ping
name: Jin, Youngnam N
name: Zylka, Mark J
name: Cheung, Chung Yan J
name: Milan, David J
name: Kokel, David
name: Jin, Shan
name: Hamblin, Michael R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Optogenetics is a powerful research tool because it enables high-resolution optical control of neuronal activity. However, current optogenetic approaches are limited to transgenic systems expressing microbial opsins and other exogenous photoreceptors. Here, we identify optovin, a small molecule that enables repeated photoactivation of motor behaviors in wild type animals. Surprisingly, optovin's behavioral effects are not visually mediated. Rather, photodetection is performed by sensory neurons expressing the cation channel TRPA1. TRPA1 is both necessary and sufficient for the optovin response. Optovin activates human TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in non-transgenic animals, including humans.
Letter from Richard Trevino to F. Lawrence Oaks, Memorandum for Undertaking at Hangar 12, Randolph Air Force Base, Texas
Creators: name: Trevino, Richard
Publisher: name: Department of the Air Force, Air Education and Training Command
Year: 2006
Subjects: subject: Randolph Field Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/83364/randolph-field-historic-landmark-district
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Military Structure
valueUri: https://core.tdar.org/browse/site-type/322/military-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Hangar 12
valueUri: https://core.tdar.org/browse/other-keyword/158750/hangar-12
subject: Aircraft Hangar
valueUri: https://core.tdar.org/browse/other-keyword/158726/aircraft-hangar
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This memorandum discusses a proposed undertaking at Hangar 12, a facility listed on the National Register of Historic Places and located within the Randolph Field Historic Landmark District. Attached are the undertaking description and assessment. Randolph Air Force Base determined an undertaking does exist with a potential to affect historic properties.