title: Ð¡Ð¸Ð½ÑÐµÐ· Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼, ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ðº ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÑ, Ð´Ð»Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Synthesis of ultrasound-sensitive liposomes for targeted drug delivery
Creators: name: ÐÐ¾ÑÐ¾Ð½Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ñ
ÑÐ»ÑÐ¾ÑÐ¾ÑÐ¾Ñ
ÐºÐ°ÑÐ´Ð¸Ð¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾Ñ
ÐºÑÐ°ÑÐ¸ÑÐµÐ»Ð¸
Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÐµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ
ÑÐ¾Ð½Ð¾Ð¿Ð¾ÑÐ°ÑÐ¸Ñ
ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐº
ÑÐ¾Ð½Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾Ñ
Ð´Ð·ÐµÑÐ°-Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»
Ð³Ð¸Ð´ÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ°Ð·Ð¼ÐµÑ
liposomes
fluorophore
cardioprotector
dyes
magnetic nanoparticles
sonoporation
ultrasound
sonosensitizer
zeta potential
hydrodynamic size

description: ÐÑÐµÐ´Ð¼ÐµÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÑÑÑÑ Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ñ, ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ðº ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÑ, Ð² ÑÐ°ÑÐ³ÐµÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ - ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ñ, ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ðº ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÑ, Ð´Ð»Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ² Ð² ÑÐ°ÑÐ³ÐµÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ¸Ð½ÑÐµÐ·Ñ Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼, ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ðº ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÑ, Ð´Ð»Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ². ÐÐ¸Ð¿Ð¾ÑÐ¾Ð¼Ñ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¸Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð´ÐµÐ³Ð¸Ð´ÑÐ°ÑÐ°ÑÐ¸Ð¸/ÑÐµÐ³Ð¸Ð´ÑÐ°ÑÐ°ÑÐ¸Ð¸ ÑÐ¾Ð½ÐºÐ¾Ð¹ Ð¿Ð»ÑÐ½ÐºÐ¸. Ð Ð°Ð·Ð±Ð¸ÐµÐ½Ð¸Ðµ Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼ ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÐ¾Ð¼ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÑÐµÐ½Ð¾ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ¾Ð½Ð¾Ð¿Ð¾ÑÐ°ÑÐ¸Ð¸. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ñ Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ Ð´Ð¾Ð±Ð°Ð²ÐºÐ°Ð¼Ð¸ Ð² Ð»Ð¸Ð¿Ð¾ÑÐ¾Ð¼Ð°Ð»ÑÐ½ÑÑ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÑ, ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ðº ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÑ, Ñ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ð¼Ð¸ Ð´Ð»Ñ Ð¸Ñ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ°Ð¼Ð¸. Ð ÑÐ¾Ð´Ðµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ° ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ðµ Ð²ÑÐµÐ¼Ñ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÐ¾Ð¼ â 5 Ð¼Ð¸Ð½ÑÑ. Ð­ÑÐ¾ Ð²ÑÐµÐ¼Ñ Ð´Ð°ÑÑ Ð¼Ð°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ðµ ÑÐ¸ÑÐ»Ð¾ ÑÐ°Ð·Ð±Ð¸Ð²ÑÐ¸ÑÑÑ Ð¸ ÑÐ²Ð¾Ð±Ð¾Ð´Ð½ÑÑ ÑÐ°ÑÑÐ¸Ñ Ñ Ð½Ð°Ð¸Ð¼ÐµÐ½ÑÑÐ¸Ð¼ ÑÑÐµÐ´Ð½Ð¸Ð¼ ÑÐ°Ð·Ð¼ÐµÑÐ¾Ð¼ Ð¸ ÑÐ²Ð»ÑÐµÑÑÑ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð±Ð»Ð°Ð³Ð¾Ð¿ÑÐ¸ÑÑÐ½ÑÐ¼ Ð´Ð»Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð° ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°. ÐÐ°Ð½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ðµ Ñ ÑÐµÐ»ÑÑ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ Ð² ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐµÑÐ°Ð½Ð¾ÑÑÐ¸ÐºÐ¸ Ð¸ ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð´Ð»Ñ ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸.
description: The given work is devoted to the synthesis of ultrasound-sensitive liposomes for targeted drug delivery. Liposomes were prepared by dehydration/rehydration of a thin membrane. The splitting of liposomes by ultrasound was verified by sonoporation. As a result, liposomes with various additives to the liposomal membrane, sensitive to ultrasound, with appropriate parameters for their functional purpose, were obtained. During the experiment, it was found that the most effective exposure time to ultrasound is 5 minutes, This time gives the maximum number of broken and free particles with the smallest average size and is the most favorable for the human body. These results can be used in medicine in order to introduce into the systems of theranostics and pharmacology for pharmacological therapy.