cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Allosteric Modulation Balances Thermodynamic Stability and Restores Function of ΔF508 CFTR
Creators: name: He, Lihua
name: Dokholyan, Nikolay V.
name: Reyes, Santiago
name: Alekseev, Alexey E.
name: Kota, Pradeep
name: Gentzsch, Martina
name: Riordan, John R.
name: Aleksandrov, Andrei A.
name: Aleksandrov, Luba A.
name: Cui, Liying
name: Jensen, Tim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Most cystic fibrosis is caused by a deletion of a single residue (F508) in CFTR that disrupts the folding and biosynthetic maturation of the ion channel protein. Progress towards understanding the underlying mechanisms and overcoming the defect remain incomplete. Here we show that the thermal instability of human ΔF508 CFTR channel activity evident in both cell-attached membrane patches and planar phospholipid bilayers is not observed in corresponding mutant CFTRs of several non-mammalian species. These more stable orthologs are distinguished from their mammalian counterparts by the substitution of proline residues at several key dynamic locations in the first nucleotide domain (NBD1), including the structurally diverse region (SDR), the gamma phosphate switch loop and the Regulatory Insertion (RI). Molecular Dynamic analyses revealed that addition of the prolines could reduce flexibility at these locations and increase the temperatures of unfolding transitions of ΔF508 NBD1 to that of the wild-type. Introduction of these prolines experimentally into full-length human ΔF508 CFTR together with the already recognized I539T suppressor mutation, also in the SDR, restored channel function and thermodynamic stability as well as its trafficking to and lifetime at the cell surface. Thus, while cellular manipulations that circumvent its culling by quality control systems leave ΔF508 CFTR dysfunctional at physiological temperature, restoration of the delicate balance between the dynamic protein’s inherent stability and channel activity returns a near-normal state.
What are the Factors That Affect Aircraft Cabin Safety? Study of Influences on Flight Attendants’ Safety Behaviours 2015
Creators: name: Stosic, Kristina
Publisher: name: figshare
Year: 2022
Subjects: subject: 150305 Human Resources Management
subject: FOS: Economics and business
subject: 111705 Environmental and Occupational Health and Safety
subject: FOS: Health sciences

description: Cabin safety plays a crucial role in the survival and injury rate of aviation incidents and accidents. A safety literature review found that limited research on aircraft cabin safety has been carried out, especially regarding the safety role of the Flight Attendants. This study aimed to fill this gap by investigating factors that affect aircraft cabin safety and are influenced by the safety behaviours of the Flight Attendants. Due to the character of the Flight Attendants’ work and identified literature gap, this study applied a qualitative methodology focused on revealing the nature of day-to-day work in relation to safety. Flight Attendants’ perceptions and interpretations of the factors that affect safety were explored through sixteen interviews. Three different ranks of Flight Attendants were interviewed, which allowed triangulation of data and provided different views of the factors that affect safety. The main findings of the study identified that systemic approach to the analysis of safety, through studies of everyday uneventful operation, has the potential to improve safety. Flight Attendants’ views can provide directions for safety enhancements, as they display awareness of the safety influencing factors, despite predominantly safe operations. It was also found that classification of safety influences in a causal manner might not be the most appropriate categorization. This is due to the revealed multifaceted features of safety causes and complex links to their outcomes. Furthermore, identified complexities were found to obscure unambiguous identification of onedimensional safety affecting factors, or at least did so within the scope of this study. This research also determined that differing job responsibilities provide different views on safety influencing factors. Establishing the most important influences presented a challenge, as Flight Attendants highlighted varying factors as strongest influences on safety, depending on their job rank. These findings reveal inconsistencies in current safety models and a need to search for comprehensive one-dimensional safety influences, with clear links to their outcomes. Moreover, this study proposes an exploration of alternative categorisations of safety, which would systematise complex correlations between safety influences, direct causes of errors and event outcomes. In addition, benefits of using the knowledge of practitioners for improvements of safety were highlighted throughout this research.
Three-point galaxy-galaxy lensing as a probe of dark matter halo shapes
Creators: name: Adhikari, Susmita
name: Chue, Chun Yin Ricky
name: Dalal, Neal
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We propose a method to measure the ellipticities of dark matter halos using the lens-shear-shear 3-point correlation function. This method is immune to effects of galaxy-halo misalignments that can potentially limit 2-point galaxy-galaxy lensing measurements of halo anisotropy. Using a simple model for the projected mass distributions of dark matter halos, we construct an ellipticity estimator that sums over all possible triangular configurations of the 3-point function. By applying our estimator to halos from N-body simulations, we find that systematic errors in the recovered ellipticity will be at the <5% fractional level. We estimate that future imaging surveys like LSST will have sufficient statistics to detect halo ellipticities using 3-point lensing.
description: 9 pages, to be submitted to JCAP
title: Umsetzung der Empfehlungen aus der zurückliegenden Evaluation der Deutschen Stiftung Friedensforschung (DSF), Osnabrück
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2023
Subjects: Evaluation
Förderverfahren
Wissenschaft und Gesellschaft
Stiftung Friedensforschung
Konfliktforschung
Förderkonzept
Strategie

description: Die Deutsche Stiftung Friedensforschung hat die primäre Aufgabe, die Friedens- und Konfliktforschung (DSF) insbesondere in Deutschland durch Forschungsförderung dauerhaft zu stärken. Der Wissenschaftsrat hatte die Rolle der DSF als Förderorganisation im Rahmen seiner Empfehlungen zur Weiterentwicklung der Friedens- und Konfliktforschung (2019) evaluiert. Wichtigstes Ergebnis der Evaluation war die Feststellung, dass die Stiftung strukturell stark unterfinanziert war, so dass ihr nur ein Verzehr des Stiftungskapitals übrigblieb. Im Bericht des Zuwendungsgebers, des Bundesministeriums für Bildung und Forschung (BMBF), wird dargelegt, dass die Bundesregierung und der Haushaltsgesetzgeber der Stiftung einen größeren finanziellen Spielraum eröffnen. Eine langfristige Lösung für die Finanzierung ist noch nicht gefunden, wird aber angestrebt.
title: Pentalogy of Cantrell and radiological findings.
Creators: name: Guzman Martinez, Nancy
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Cardiac
subject: CT-Angiography
subject: Education
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To learn aboutthe Cantrell's pentalogy To describe CT- angiography cardiac imaging findings the Cantrell's pentalogy To identify anomalies associated to Cantrell's pentalogy To learn the prognosis of Cantrell's...
What are the Factors That Affect Aircraft Cabin Safety? Study of Influences on Flight Attendants’ Safety Behaviours
Creators: name: Stosic, Kristina
Publisher: name: figshare
Year: 2022
Subjects: subject: 150305 Human Resources Management
subject: FOS: Economics and business
subject: 111705 Environmental and Occupational Health and Safety
subject: FOS: Health sciences

description: Cabin safety plays a crucial role in the survival and injury rate of aviation incidents and accidents. A safety literature review found that limited research on aircraft cabin safety has been carried out, especially regarding the safety role of the Flight Attendants. This study aimed to fill this gap by investigating factors that affect aircraft cabin safety and are influenced by the safety behaviours of the Flight Attendants. Due to the character of the Flight Attendants’ work and identified literature gap, this study applied a qualitative methodology focused on revealing the nature of day-to-day work in relation to safety. Flight Attendants’ perceptions and interpretations of the factors that affect safety were explored through sixteen interviews. Three different ranks of Flight Attendants were interviewed, which allowed triangulation of data and provided different views of the factors that affect safety. The main findings of the study identified that systemic approach to the analysis of safety, through studies of everyday uneventful operation, has the potential to improve safety. Flight Attendants’ views can provide directions for safety enhancements, as they display awareness of the safety influencing factors, despite predominantly safe operations. It was also found that classification of safety influences in a causal manner might not be the most appropriate categorization. This is due to the revealed multifaceted features of safety causes and complex links to their outcomes. Furthermore, identified complexities were found to obscure unambiguous identification of onedimensional safety affecting factors, or at least did so within the scope of this study. This research also determined that differing job responsibilities provide different views on safety influencing factors. Establishing the most important influences presented a challenge, as Flight Attendants highlighted varying factors as strongest influences on safety, depending on their job rank. These findings reveal inconsistencies in current safety models and a need to search for comprehensive one-dimensional safety influences, with clear links to their outcomes. Moreover, this study proposes an exploration of alternative categorisations of safety, which would systematise complex correlations between safety influences, direct causes of errors and event outcomes. In addition, benefits of using the knowledge of practitioners for improvements of safety were highlighted throughout this research.
title: Stellungnahme zur Institutionellen Reakkreditierung der Hochschule für Künste im Sozialen, Ottersberg
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2023
Subjects: Akkreditierung
Hochschulförmigkeit
Qualitätssicherung
Private Hochschulen
Hochschulen
Akkreditierungszeitraum 5 plus 5 Jahre
Künste

description: Die Hochschule für Künste im Sozialen, Ottersberg wird vom Wissenschaftsrat unter Auflagen für die Dauer von zunächst fünf Jahren reakkreditiert. Der Akkreditierungszeitraum verlängert sich bei fristgerechter Erfüllung der Auflagen auf zehn Jahre. Die Hochschule ging 1984 aus der Freien Kunststudienstätte Ottersberg hervor und ist unbefristet staatlich anerkannt. Ihren rund 340 Studierenden bietet sie (Stand: WS 2022/23) vier Bachelorstudiengänge und einen Masterstudiengang mit künstlerischen und künstlerisch-angewandten Schwerpunkten an.
D3.2 - GW Analysis Tools
Creators: name: Razzano, Massimiliano
name: Di Renzo, Francesco
name: Fidecaro, Francesco
name: Hemming, Gary
Publisher: name: Zenodo
Year: 2021

description: This report describes the REINFORCE Deliverable D3.2 “GW Analysis Tools”. The document describes the software packages that have been developed to prepare the gravitational-wave data in order for it to be integrated into the WP3 demonstrator on the Zooniverse platform (see Deliverable D3.3). The document describes the latest updates of the data-preparation pipeline and the relative software-analysis tools. We also discuss the tools that will be used to interface the data classified and processed by the citizens to the machine-learning pipeline. We also discuss future prospects, considering the data expected to be produced by the citizen scientists involved
 in the project.
Broad Ranges of Affinity and Specificity of Anti-Histone Antibodies Revealed by a Quantitative Peptide Immunoprecipitation Assay
Creators: name: Koide, Shohei
name: Yasui, Norihisa
name: Nishikori, Shingo
name: Strahl, Brian D.
name: Fuchs, Stephen M.
name: Koide, Akiko
name: Wojcik, John
name: Hattori, Takamitsu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Antibodies directed against histone posttranslational modifications (PTMs) are critical tools in epigenetics research, particularly in the widely used chromatin immunoprecipitation (ChIP) experiments. However, a lack of quantitative methods for characterizing such antibodies has been a major bottleneck in accurate and reproducible analysis of histone modifications. Here, we report a simple and sensitive method for quantitatively characterizing polyclonal and monoclonal antibodies for histone PTMs in a ChIP-like format. Importantly, it determines the apparent dissociation constants for the interactions of an antibody with peptides harboring cognate or off-target PTMs. Analyses of commercial antibodies revealed large ranges of affinity, specificity and binding capacity as well as substantial lot-to-lot variations, suggesting the importance of quantitatively characterizing each antibody intended to be used in ChIP experiments and optimizing experimental conditions accordingly. Furthermore, using this method we identified additional factors potentially affecting the interpretation of ChIP experiments.
Gradient estimates for inverse curvature flows in hyperbolic space
Creators: name: Scheuer, Julian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We prove gradient estimates for hypersurfaces in the hyperbolic space $\mathbb{H}^{n+1},$ expanding by negative powers of a certain class of homogeneous curvature functions. We obtain optimal gradient estimates for hypersurfaces evolving by certain powers $p>1$ of $F^{-1}$ and smooth convergence of the properly rescaled hypersurfaces. In particular, the full convergence result holds for the inverse Gauss curvature flow of surfaces without any further pinching condition besides convexity of the initial hypersurface.
description: 7 pages. Discussions are welcome
Hotspot analysis of most impactful industrial processes
Creators: name: Charpentier Poncelet, Alexandre
name: Vidinha, Margarida
name: Schrijvers, Dieuwertje
name: Szablewski, Carolina
name: Adibi, Naeem
name: Neuwirth, Josefin
name: Midander, Klara
name: Lidberg, Maria
name: Elginoz Kanat, Nilay
name: Safarianbana, Sahar
name: Lidfeldt, Matilda
name: Méndez, Ricardo
name: Cáceres, Alfredo
name: Schaubroeck, Thomas
name: Amaral, Milena
name: Coello, Tamara
Publisher: name: Zenodo
Year: 2023
Subjects: Hotspot
Industrial processes
Bio-industry
LCSA
LCA

description: The CALIMERO project is positioned in an area where activities are meant to foster innovation to develop the circular economy and exploit the potential of biological resources for renewable products, thus reducing the EU's dependence on non-renewable resources.In this deliverable, the key materials and processes for the five bio-based sectors covered within the project (biochemicals, pulp and paper, textile, woodworking, and construction) are identified; environmental, social, and economic hotspots are identified for those sectors through (i) a literature review and (ii) existing methodologies and tools; and potential gaps in the sustainability hotspot identification due to a lack of data in existing databases and existing methods and tools across the three sustainability pillars are identified. Detailed sectorial analyses are provided for each sector and each sustainability pillar in the report.The information gathered and analysis in this deliverable provides a holistic overview of expected environmental, social, and economic hotspots for the five bio-based sectors. It will provide a solid basis for targeting and supporting further developments of the CALIMERO project.
title: Stellungnahme zum Max Rubner-Institut - Bundesforschungsinstitut für Ernährung und Lebensmittel (MRI), Karlsruhe
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2023
Subjects: Evaluation
Ressortforschung
Forschungsinfrastrukturen
Altersforschung
Politikberatung
Bundesministerium für Familie
Transfer

description: Das Max Rubner-Institut forscht und berät zu den gesellschaftlich relevanten Themen Lebensmittelsicherheit und Ernährungsverhalten sowie zum gesundheitlichen Verbraucherschutz. Hierbei verfolgt es zukunftsweisende Ansätze wie Metabolomics. Künftig sollte das Institut profilgebende Schwerpunkte wie Nachhaltigkeit in der Ernährung oder Lebensmittel-Systembiologie noch stärker in den Mittelpunkt stellen. Hierfür wird dem Institut eine Umstrukturierung einiger Fachinstitute, eine intensivere Vernetzung innerhalb des Instituts und mit weiteren Einrichtungen der Ernährungsforschung sowie eine Fokussierung seines Forschungsprogramms empfohlen.
title: Computed tomographic features of lung parenchyma: over time after cardiopulmonary resuscitation
Creators: name: Ryu, Hyeonmi
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Lung
subject: CT
subject: Comparative studies

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: This study was an attempt to identify key CT features of lung parenchyma over time after cardiopulmonary...
Isochrones for Old (> 5 Gyr) Stars and Stellar Populations. I. Models for $-2.4 \le$ [Fe/H] $\le +0.6$, $0.25 \le Y \le 0.33$, and $-0.4 \le$ [$α$\Fe] $\le +0.4$
Creators: name: VandenBerg, Don A.
name: Bergbusch, Peter A.
name: Ferguson, Jason W.
name: Edvardsson, Bengt
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Canonical grids of stellar evolutionary sequences have been computed for the helium mass-fraction abundances $Y = 0.25$, $0.29$, and $0.33$, and for iron abundances that vary from $-2.4$ to $+0.4$ (in 0.2 dex increments) when [$α$/Fe] $= +0.4$, or for the ranges $-2.0 \le$ [Fe/H] $\le +0.6$, $-1.8 \le$ [Fe/H] $\le +0.6$ when [$α$/Fe] $= 0.0$ and $-0.4$, respectively. The grids, which consist of tracks for masses from $0.12 {{\cal M}_\odot}$ to $1.1$-$1.5 {{\cal M}_\odot}$ (depending on the metallicity) are based on up-to-date physics, including the gravitational settling of helium (but not metals diffusion). Interpolation software is provided to generate isochrones for arbitrary ages between $\approx 5$ and $15$ Gyr and any values of $Y$, [$α$/Fe], and [Fe/H] within the aforementioned ranges. Comparisons of isochrones with published color-magnitude diagrams (CMDs) for the open clusters M67 ([Fe/H] $\approx 0.0$) and NGC 6791 ([Fe/H] $\approx 0.3$) and for four of the metal-poor globular clusters (47 Tuc, M3, M5, and M92) indicate that the models for the observed metallicities do a reasonably good job of reproducing the locations and slopes of the cluster main sequences and giant branches. The same conclusion is reached from a consideration of plots of nearby subdwarfs that have accurate Hipparcos parallaxes and metallicities in the range $-2.0 \le$ [Fe/H] $\le -1.0$ on various CMDs and on the ($\log T_{\rm eff},\,M_V$)-diagram. A relatively hot temperature scale similar to that derived in recent calibrations of the infrared flux method is favored by both the isochrones and the adopted color transformations, which are based on the latest MARCS model atmospheres.
description: 55 pages, including 1 table and 18 figures; accepted for publication in the Astrophysical Journal
Linearization of partial quasi-orderings in the Solovay model revisited
Creators: name: Kanovei, Vladimir
name: Lyubetsky, Vassily
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03E15, 03E45

description: We modify arguments in Vladimir Kanovei, Linearization of definable order relations, APAL, 102(1-2):69--100, 2000, to reprove a linearization theorem on real-ordinal definable partial quasi-orderings in the Solovay model.
description: Partial support of RFFI grant 13-01-00006 acknowledged
Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosa
Creators: name: Cann, Martin J.
name: Fulcher, Nanette B.
name: Levin, Lonny R.
name: Bitterman, Jacob
name: Buck, Jochen
name: Steegborn, Clemens
name: Wolfgang, Matthew C.
name: Salazar, Eric
name: Topal, Hüsnü
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Pseudomonas aeruginosa is an opportunistic bacterial pathogen and major cause of healthcare-associated infections. While the organism’s intrinsic and acquired resistance to most antibiotics hinders treatment of P. aeruginosa infections, the regulatory networks controlling its virulence provide novel targets for drug development. CyaB, a key regulator of P. aeruginosa virulence, belongs to the Class III adenylyl cyclase (AC) family of enzymes that synthesize the second messenger cyclic adenosine 3′,5′-monophosphate (cAMP). These enzymes consist of a conserved catalytic domain fused to one or more regulatory domains. We describe here the biochemical and structural characterization of CyaB and its inhibition by small molecules. We show that CyaB belongs to the Class IIIb subfamily and, like other subfamily members, its activity is stimulated by inorganic carbon. CyaB is also regulated by its N-terminal MASE2 domain, which acts as a membrane anchor. Using a genetic screen, we identified activating mutations in CyaB. By solving the crystal structure of the CyaB catalytic domain, we rationalized the effects of these mutations and propose that CyaB employs regulatory mechanisms similar to other Class III ACs. The CyaB structure further indicates subtle differences compared to other Class III ACs in both the active and inhibitor binding pocket. Consistent with these differences, we observed a unique inhibition profile, including identification of a CyaB selective compound. Overall, our results reveal mechanistic details of the physiological and pharmacological regulation of CyaB and provide the basis for its exploitation as a therapeutic drug target.
title: Stellungnahme zur Institutionellen Reakkreditierung der SRH Wilhelm Löhe Hochschule, Fürth
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2023
Subjects: Akkreditierung
Hochschulförmigkeit
Qualitätssicherung
Private Hochschulen
Hochschulen
Akkreditierungszeitraum 5 Jahre
Gesundheit

description: Die SRH Wilhelm Löhe Hochschule in Fürth wird vom Wissenschaftsrat unter Auflagen für die Dauer von fünf Jahren reakkreditiert. Die Hochschule wurde 2012 gegründet und ist derzeit befristet staatlich anerkannt. Sie bietet ihren rund 600 Studierenden (Stand: WS 2022/23) Bachelorstudiengänge in Vollzeit-, berufs- und ausbildungsbegleitenden Formaten sowie berufsbegleitende Masterstudiengänge im Bereich des Gesundheits- und Sozialwesens an.
Reservoir spectroscopy of 5s5p $^3$P$_2$ - 5s$n$d $^3$D$_{1,2,3}$ transitions in strontium
Creators: name: Stellmer, Simon
name: Schreck, Florian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We perform spectroscopy on the optical dipole transitions 5s5p $^3$P$_2$ - 5s$n$d $^3$D$_{1,2,3}$, $n \in (5,6)$, for all stable isotopes of atomic strontium. We develop a new spectroscopy scheme, in which atoms in the metastable $^3$P$_2$ state are stored in a reservoir before being probed. The method presented here increases the attained precision and accuracy by two orders of magnitude compared to similar experiments performed in a magneto-optical trap or discharge. We show how the state distribution and velocity spread of atoms in the reservoir can be tailored to increase the spectroscopy performance. The absolute transition frequencies are measured with an accuracy of 2 MHz. The isotope shifts are given to within 200 kHz. We calculate the $A$ and $Q$ parameters for the hyperfine structure of the fermionic isotope at the MHz-level. Furthermore, we investigate the branching ratios of the $^3$D$_{J}$ states into the $^3$P$_{J}$ states and discuss immediate implications on schemes of optical pumping and fluorescence detection.
description: 15 pages, 7 figures, 4 tables
Original oder Schüler? Einsatzmöglichkeiten Künstlicher Intelligenz bei Zuschreibungsfragen am Beispiel des Rembrandt Research Projects
Creators: name: Reuter, Wolfgang
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 700 Künste, Bildende Kunst allgemein

description: Künstliche Intelligenz (KI) wird von Kunsthistorikern bisher kaum genutzt, um Kunstwerke zu analysieren. In der vorliegenden Studie erörtern wir zunächst einige der Gründe dafür. Vor allem aber zeigen wir, wie die Methoden und Verfahren des Maschinellen Lernens, einem Teilgebiet der Künstlichen Intelligenz, neben anderen Analysetechniken in diesem Wissenschaftszweig, die Experten bei ihrer Arbeit unterstützen können. Zu diesem Zweck haben wir ein Ensemble aus Konvolutionalen Neuronalen Netzen (Convolutional Neural Networks, CNNs) mit 2.258 Werken von Rembrandt und 14 Schülern dieses barocken Werkstattmalers trainiert. Mit diesem Modell haben wir exemplarisch 15 Entscheidungen des Rembrandt Research Projects (RRP) überprüft, einer über Jahrzehnte andauernden interdisziplinären Forschungsarbeit von zahlreichen Kunst-Experten. Dabei haben wir eine Evaluationsmetrik angewandt, die sicherstellt, dass die Vorhersagen des Modells nur dann akzeptiert werden, wenn sie sehr eindeutig sind. Dies führt dazu, dass dieses Modell in etwa einem Drittel der Fälle keine Aussage trifft, die Vorhersage in den übrigen zwei Dritteln der Fälle jedoch deutlich sicherer ist und ernst genommen werden sollte. Insgesamt konnten wir mit dieser Vorgehensweise die meisten der Entscheidungen des RRP bestätigen. In zwei Fällen gibt das Modell klare Hinweise auf höchstwahrscheinlich falsche Abschreibungen von Rembrandt Originalen. In einem weiteren Fall, der unseres Wissens nicht vom RRP überprüft wurde, sollte eine Zuschreibung ernsthaft erwogen werden. Zudem haben wir einen Ansatz entwickelt, mit dem sich die Genauigkeit von Kunsthistorikern bei der Zu- und Abschreibung von Werken aus dem Umfeld Rembrandts evaluieren lässt – vor allem, um eine Vorstellung von der Qualität der Labels zu bekommen, die mit den Daten assoziiert sind, also von der Sicherheit der Zuschreibungen zu einzelnen Künstlern. Es geht uns in der vorliegenden Arbeit explizit nicht um den generell üblichen und aus unserer Sicht sinnlosen Vergleich zwischen menschlicher und Künstlicher Intelligenz. Stattdessen zeigen wir auf, wie die Ergebnisse von KI-Verfahren Kunstexperten Hinweise auf mögliche weitere Untersuchungen geben können, selbst wenn diese Ergebnisse nicht völlig eindeutig sind. Hierzu wenden wir exemplarisch weitere Analysemethoden und Algorithmen aus dem Bereich Computer Vision auf einzelne Beispielbilder an. Dieses Paper richtet sich explizit nicht nur an KI-Experten, sondern auch an Kunsthistoriker und andere Interessierte. Aus diesem Grund werden einige Vorgehensweisen und Prinzipien des Maschinellen Lernens ausführlicher behandelt, als dies in Publikationen dieses Fachgebietes normalerweise üblich ist.
Metal-Dielectric-Graphene Sandwich for Surface Enhanced Raman Spectroscopy
Creators: name: Yu, Xuechao
name: Tao, Jin
name: Shen, Youde
name: Liang, Guozhen
name: Liu, Tao
name: Zhang, Yongzhe
name: Wang, Qi Jie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Raman intensity of Rhodamine B (RhB) is enhanced by inserting a thin high \k{appa} dielectric layer which reduces the surface plasmon damping at the gold-graphene interface. The results indicate that the Raman intensity increases sharply by plasmonic resonance enhancement while maintaining efficient fluorescence quenching with optimized dielectric layer thickness.
description: accepted by Nanoscale
title: Altered functional connectivity of SMA subregions in well-recovered stroke patients
Creators: name: Liu, Huaigui
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Anatomy
subject: MR-Functional imaging
subject: MR-Diffusion/Perfusion
subject: Physiological studies
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The supplementary motor area (SMA) contains two subregions: the SMA proper connects with motor areas and involves in motor execution; the preSMA connects with prefrontal areas and involves in higher-level processing. The resting-state functional...
Local Unfolding of Cu, Zn Superoxide Dismutase Monomer Determines the Morphology of Fibrillar Aggregates
Creators: name: Furukawa, Yoshiaki
name: Ding, Feng
name: Dokholyan, Nikolay V.
name: Nukina, Nobuyuki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Aggregation of Cu, Zn Superoxide Dismutase (SOD1) is often found in Amyotrophic Lateral Sclerosis (ALS) patients. The fibrillar aggregates formed by wildtype and various disease-associated mutants have recently been found to have distinct cores and morphologies. Previous computational and experimental studies of wildtype SOD1 suggest that the apo-monomer, highly aggregation-prone, displays substantial local unfolding dynamics. The residual folded structure of locally unfolded apoSOD1 corresponds to peptide segments forming the aggregation core as identified by a combination of proteolysis and mass spectroscopy. Therefore, we hypothesize that the destabilization of apoSOD1 caused by various mutations leads to distinct local unfolding dynamics. The partially unfolded structure, exposing the hydrophobic core and backbone hydrogen bond donors and acceptors, is prone to aggregate. The peptide segments in the residual folded structures form the “building block” for aggregation, which in turn determines the morphology of the aggregates. To test this hypothesis, we apply a multiscale simulation approach to study the aggregation of three typical SOD1 variants: wildtype, G37R, and I149T. Each of these SOD1 variants has distinct peptide segments forming the core structure and features different aggregate morphologies. We perform atomistic molecular dynamics simulations to study the conformational dynamics of apoSOD1 monomer, and coarse-grained molecular dynamics simulations to study the aggregation of partially unfolded SOD1 monomers. Our computational studies of monomer local unfolding and the aggregation of different SOD1 variants are consistent with experiments, supporting the hypothesis of the formation of aggregation “building blocks” via apo-monomer local unfolding as the mechanism of SOD1 fibrillar aggregation.
title: ИМПОРТ АВТОКОМПОНЕНТОВ КАК ФАКТОР ЛАБИЛЬНОСТИ РЫНКА АВТОМОБИЛЕСТРОЕНИЯ
Creators: name: Капустина, Ирина
name: Григорьева, Ксения
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Современное положение России в системе мирохозяйственных связей, характеризующееся стремительной политической и экономической изоляцией на международной арене, придя на смену продолжительного курса страны с ориентацией на углубление интеграционных связей, ставит новые задачи перед отечественной экономикой. Так, вопрос дальнейшего функционирования отраслей промышленности с высоким уровнем импортозависимости, в частности автомобилестроения, остается не только неразрешенным, но ключевым с точки зрения его дальнейшего существования. В действительности, даже в сравнительно благоприятных условиях для повышения национальной безопасности в секторе автомобилестроения, деятельность по сокращению разрыва в материальной гарантированности автокомпонентами отечественного производства по сравнению с мировой практикой не принесла значительных результатов, а лишь приобрела поверхностный характер. Исходя из этого, особенный научный и практический интерес представляет реальная оценка необходимости импорта в секторе отечественного автопрома и исследование настоящих условий и перспектив адаптации отрасли к вызовам современности.
title: New ACR TI-RADS: Know Whether You Know
Creators: name: Geetha Virupakshappa, SanthoshKumar
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Head and neck
subject: Thyroid / Parathyroids
subject: Ear / Nose / Throat
subject: Ultrasound
subject: Audit and standards
subject: Education
subject: Structured reporting
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Introduction to the salient features of the new ACR TI-RADS (American College of Radiology Thyroid Imaging, Reporting and Data System) classification. A pictorial quiz on thyroid...
title: Stellungnahme zur Institutionellen Reakkreditierung der ESAB Fachhochschule für Sport und Management Potsdam
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2023
Subjects: Akkreditierung
Hochschulförmigkeit
Qualitätssicherung
Private Hochschulen
Hochschulen
Akkreditierungszeitraum 5 Jahre
Sport

description: Die ESAB Fachhochschule für Sport und Management Potsdam wird vom Wissen-schaftsrat für die Dauer von fünf Jahren reakkreditiert. Die ESAB Fachhochschule für Sport und Management Potsdam (FHSMP) wurde 2009 gegründet und ist seitdem befristet staatlich anerkannt. Sie bietet ihren derzeit rund 450 Studierenden zwei duale Bachelorstudiengänge in den Bereichen angewandte Sportwissenschaft und Management an. Zu Beginn des Wintersemesters 2022/23 beschäftigte die FHSMP neun hauptberufliche Professorinnen und Professoren in einem Umfang von 8,7 VZÄ (inkl. Hochschulleitung).
Redesigning the NEDD8 Pathway with a Bacterial Genetic Screen for Ubiquitin-Like Molecule Transfer
Creators: name: Guntas, Gurkan
name: Kuhlman, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Pathways of ubiquitin-like (UBL) molecule transfer regulate a myriad of cellular cascades. Here we report a high-throughput assay that correlates catalytic human-NEDD8 transfer to bacterial survival. The assay was utilized to screen mutant NEDD8 and NEDD8-activating enzyme (NAE) libraries to engineer a more stable NEDD8 and redesign the NEDD8-NAE interface. This approach will be useful in understanding the specificities underlying UBL pathways.
title: Clinical applications of arterial spin labeling in arteriovenous fistula and malformation
Creators: name: LEE, Kam Ho
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Imaging sequences
subject: MR-Angiography
subject: MR
subject: Vascular
subject: Neuroradiology brain
subject: CNS
subject: Arteriovenous malformations
subject: Fistula

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To review the concepts and principles of arterial spin labeling (ASL). 2. To describe and depict the role of ASL in dural arteriovenous fistula (DAVF) and arteriovenous malformation (AVM). 3. To discuss the potential pitfalls and limitations...
Countermeasures to Achieve High-quality Development of Dairy Industry in Xinjiang: A Case Study of Tianrun Dairy Industry
Creators: name: LIANG, Chunming
name: LIU, Jinding
name: XUE, Xiaobo
name: FARRUH, ANWAR
name: CAO, Lijun
name: LIANG, Chunming
name: LIU, Jinding
name: XUE, Xiaobo
name: FARRUH, ANWAR
name: CAO, Lijun
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: Leading enterprise, High-quality development, Dairy industry, Benefit distribution

description: As a high-quality milk source base in China, Xinjiang has an innate foundation for the development of modern high-quality milk industry. In this paper, it was pointed out that the uneven distribution of interests between the upstream and downstream of the industry was the influencing factor restricting the development of modern dairy industry in Xinjiang. At the same time, the related information of Tianrun Group, which was the leading enterprise in Xinjiang, was analyzed. According to analysis, it was found that through the construction and development of large-scale, standardized and modern milk source base, balance of the upstream and downstream interests, improvement of the combination system of planting and breeding, the added value of products was enhanced and the anti risk ability of enterprises was increased. In addition, it was also pointed out that under the leadership of leading enterprises, Xinjiang would embark on the development road of modern high-quality milk industry with circular economy, resource-saving, environment-friendly, quality and efficiency, operation-saving, independent innovation and industrial integration in the future.
Improving Accessibility of Archived Raster Dictionaries of Complex Script Languages
Creators: name: Alam, Sawood
name: Mehmood, Fateh ud din B
name: Nelson, Michael L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Digital Libraries (cs.DL)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences
subject: H.3.3

description: We propose an approach to index raster images of dictionary pages which in turn would require very little manual effort to enable direct access to the appropriate pages of the dictionary for lookup. Accessibility is further improved by feedback and crowdsourcing that enables highlighting of the specific location on the page where the lookup word is found, annotation, digitization, and fielded searching. This approach is equally applicable on simple scripts as well as complex writing systems. Using our proposed approach, we have built a Web application called "Dictionary Explorer" which supports word indexes in various languages and every language can have multiple dictionaries associated with it. Word lookup gives direct access to appropriate pages of all the dictionaries of that language simultaneously. The application has exploration features like searching, pagination, and navigating the word index through a tree-like interface. The application also supports feedback, annotation, and digitization features. Apart from the scanned images, "Dictionary Explorer" aggregates results from various sources and user contributions in Unicode. We have evaluated the time required for indexing dictionaries of different sizes and complexities in the Urdu language and examined various trade-offs in our implementation. Using our approach, a single person can make a dictionary of 1,000 pages searchable in less than an hour.
description: 11 pages, 5 images, 2 codes, 1 table
Tandem PHD Fingers of MORF/MOZ Acetyltransferases Display Selectivity for Acetylated Histone H3 and Are Required for the Association with Chromatin
Creators: name: Côté, Jacques
name: Ali, Muzaffar
name: Yang, Xiang-Jiao
name: Rothbart, Scott B.
name: Degerny, Cindy
name: Lalonde, Marie-Eve
name: Strahl, Brian D.
name: Kutateladze, Tatiana G.
name: Yan, Kezhi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: MORF (monocytic leukemia zinc-finger protein (MOZ)-related factor) and MOZ are catalytic subunits of histone acetyltransferase (HAT) complexes essential in hematopoiesis, neurogenesis, skeletogenesis and other developmental programs and implicated in human leukemias. The canonical HAT domain of MORF/MOZ is preceded by a tandem of plant homeodomain (PHD) fingers whose biological roles and requirements for MORF/MOZ activity are unknown. Here we demonstrate that the tandem PHD1/2 fingers of MORF recognize the N-terminal tail of histone H3. Acetylation of Lys9 (H3K9ac) or Lys14 (H3K14ac) enhances binding of MORF PHD1/2 to unmodified H3 peptides two to three fold. The selectivity for acetylated H3 tail is conserved in the double PHD1/2 fingers of MOZ. This interaction requires the intact N-terminus of histone H3 and is inhibited by trimethylation of Lys4. Biochemical analysis using NMR, fluorescence spectroscopy and mutagenesis identified key amino acids of MORF PHD1/2 necessary for the interaction with histones. Fluorescence microscopy and immunoprecipitation experiments reveal that both PHD fingers are required for binding to H3K14ac in vivo and localization to chromatin. The HAT assays indicate that the interaction with H3K14ac may promote enzymatic activity in trans. Together, our data suggest that the PHD1/2 fingers play a role in MOZ/MORF HATs association with the chromatic regions enriched in acetylated marks.
title: Posteromedial corner of the knee injuries resulting in anteromedial rotational instability: an illustratory case, literature review of epidemiology, radiological features and management strategies
Creators: name: Crilly, Shane
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Trauma
subject: Outcomes
subject: Epidemiology
subject: Surgery
subject: Physiological studies
subject: Health policy and practice
subject: MR
subject: Digital radiography
subject: Conventional radiography
subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint
subject: Bones

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Posteromedial corner of the knee (PMC) injuries are relatively uncommon. It isimportant for the radiologist to be aware of the PMC because of the potential forthe development of anteromedial rotational instability (AMRI) resulting from injury to the...
5G-IANA D1.5 Data Management Plan V2
Creators: name: Andrea Suarez Garcia
Publisher: name: Zenodo
Year: 2023

description: This deliverable, D1.5 - Data Management Plan v2 aims at providing a detailed description of the data to be generated during the implementation of the project, whether and how it will be exploited or made accessible for verification and re-use, and how it will be curated and preserved. The deliverable is based on the first version of the data management plan (D1.4).
Some improvements of the Katznelson-Tzafriri theorem on Hilbert space
Creators: name: Seifert, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: This paper extends two recent improvements in the Hilbert space setting of the well-known Katznelson-Tzafriri theorem by establishing both a version of the result valid for bounded representations of a large class of abelian semigroups and a quantified version for contractive representations. The paper concludes with an outline of an improved version of the Katznelson-Tzafriri theorem for individual orbits, whose validity extends even to certain unbounded representations.
description: 13 pages, to appear in Proceedings of the American Mathematical Society
Wie lange muss jemand hier leben? Migration und Identität
Creators: name: Völkel, Bärbel
Publisher: name: B.Völkel, Wie lange muss jemand hier leben? Migration und Identität, «Public history weekly», 2, 2014, n. 7
Year: 2014

description: In den Jahren 2010 bis 2012 konnte man eine Diskussion verfolgen, die sich an einer Rede des Bundespräsidenten Wulff entzündete. Wulff betonte seinerzeit, der Islam gehöre heute, ebenso wie das Christentum und das Judentum, zu Deutschland.1 Widerspruch kam von den führenden CDU/CSU-Politikern Hans-Peter Friedrich und Volker Kauder. Sie erklärten, der Islam gehöre historisch nicht zu Deutschland, er präge nicht die deutsche Kultur und Identität, auch wenn Muslime heute zu Deutschland gehörten und als Staatsbürger alle Staatsbürgerrechte genießen würden. Das sicherzustellen, sei Aufgabe des Staates.
The Role of the β5–α11 Loop in the Active-Site Dynamics of Acylated Penicillin-Binding Protein A from Mycobacterium tuberculosis
Creators: name: Fedarovich, Alena
name: Nicholas, Robert A.
name: Davies, Christopher
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Penicillin-binding protein A (PBPA) is a class B penicillin-binding protein that is important for cell division in M. tuberculosis. We have determined a second crystal structure of PBPA in apo form and compared it with an earlier structure of the apo enzyme. Significant structural differences in the active site region are apparent, including increased ordering of a β-hairpin loop and a shift of the SxN active site motif such that it now occupies a position that appears catalytically competent. Using two assays, including one that uses the intrinsic fluorescence of a tryptophan residue, we have also measured second-order acylation rate constants for the antibiotics, imipenem, penicillin G and ceftriaxone. Of these, imipenem, which has demonstrable antitubercular activity, shows the highest acylation efficiency. Crystal structures of PBPA in complex with the same antibiotics were also determined and all show conformational differences in the β5-α11 loop near the active site, but these differ for each β-lactam and also for each of the two molecules in the crystallographic asymmetric unit. Overall, these data reveal the β5-α11 loop of PBPA as a flexible region that appears important for acylation and provide further evidence that PBPs in apo form can occupy different conformational states.
Die Schatten der Perspektive: Maschinenzeichnungen und die geometrische Kunst am Übergang zum 19. Jahrhundert
Creators: name: Kleinberger-Pierer, Harald
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 700 Künste, Bildende Kunst allgemein

description: Mit dem 18. Jahrhundert bildete sich verstärkt ein genuines Modell des technischen Zeichnens heraus, das unter anderem in die darstellende moderne Geometrie mündete. Die darstellende Geometrie als Wissenschaft der technischen Zeichnung und Maschinenzeichnung um 1800 integrierte auch die Schattenkonstruktion in ihre Theorie und Praxis. Beginnend mit Gaspard Monge, Barnabé Brisson, Guido Schreiber und anderen wurde der Schatten und dessen Konstruktion in einer Vielzahl von Traktaten zur Zeichenkunst bearbeitet. Der Zweck und die Ausführung des Schattens wurde von den Autoren in der ersten Hälfte des 19. Jahrhunderts unterschiedlich interpretiert, vor allem in Hinblick auf Maschinenzeichnungen: Einerseits als Werkzeug für mehr Harmonie in einer Zeichnung, andererseits als Hilfsmittel zur verstärkten Anschaulichkeit, Verständlichkeit und Nachvollziehbarkeit für ungeübte Betrachter von technischen Zeichnungen. Aber auch gegenteilige Ansichten zur Verwendung des Schattens wurden formuliert, die ausufernde Schattenkonstruktionen mit einer schlechteren Nachvollziehbarkeit und reduzierter technischer Dokumentation in Verbindung brachten, und den Schatten dementsprechend als störend und dem Zweck der Zeichnung widersprechend empfanden. Im Fokus dieses Artikels steht die Darstellung unterschiedlicher Sichtweisen zum Zweck des Schattens von Autoren des 19. Jahrhunderts. Des Weiteren wird das Verhältnis zwischen technischem und künstlerischem Zeichnen diskutiert und die Rolle der Ästhetik beim technischen Zeichnen und der geometrischen Kunst des Schattens diskutiert.