Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
Creators: name: Padilla, Carlos
name: Dinardo, Carla
name: Guo, Bing
name: Mata, Ignacio F.
name: Johnsen, Jill M.
name: Kaplan, Robert C.
name: Preuss, Michael
name: Santos-Lobato, Bruno Lopes
name: Arboleda, Gonzalo
name: Schumacher-Schuh, Artur Francisco
name: Custer, Brian
name: Reiner, Alexander P.
name: Institute of Neurological Disorders and Stroke Stroke Genetics Network Consortium
name: Ikpe, Sunday
name: North, Kari E.
name: Barreto, Mauricio L.
name: Loesch, Douglas P.
name: O’Connor, Timothy D.
name: Chana-Cuevas, Pedro
name: Silverman, Edwin K.
name: Laboulaye, Roland
name: Weiss, Scott T.
name: Alvim, Isabela
name: Veliz-Otani, Diego
name: Chen, Zhanghua
name: Sacco, Ralph L.
name: Hernandez, Ryan D.
name: Raggio, Victor
name: Gogarten, Stephanie M.
name: Sofer, Tamar
name: Latin American Research Consortium on the Genetics of Parkinson’s Disease
name: Leal, Thiago Peixoto
name: Kooperberg, Charles
name: Sanchez, Cesar
name: Domingos, Igor
name: Tarazona-Santos, Eduardo
name: Sankaran, Vijay G.
name: Blangero, John
name: Scliar, Marilia O.
name: Duggirala, Ravindranath
name: Dieguez, Elena
name: Mendes, Marla
name: Rich, Stephen S.
name: Kenny, Eimear E.
name: Fernandez, Willian
name: French, Jennifer N.
name: Meyers, Deborah A.
name: Rieder, Carlos R.
name: Konkle, Barbara A.
name: Ferraz, Henrique B.
name: Lescano, Andres
name: Bezzera, Marcos A.
name: Loos, Ruth J.F.
name: Horta, Bernardo
name: Lima-Costa, M. Fernanda
name: Rotter, Jerome I.
name: Gilliland, Frank
name: Curran, Joanne E.
name: Manichaikul, Ani
name: Borda, Victor
name: Barwick, Lucas
name: Naslavsky, Michel S.
name: Tumas, Vitor
name: Cai, Jianwen
name: Nickerson, Deborah A.
name: Borges, Vanderci
name: Guio, Heinner
name: Arboleda-Bustos, Carlos E.
name: Lasky-Su, Jessica
name: Caceres, Omar
name: Gouveia, Mateus H.
name: Rienstra, Michiel
name: Kelly, Shannon
name: Rundek, Tatjana
name: Abecasis, Gonçalo R.
name: Dean, Michael
name: Arboleda, Humberto
name: Trans-Omics for Precision Medicine Population Genetics Working Group
Publisher: name: Elsevier
Year: 2024

description: Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing statistics (i.e., allele and haplotype frequencies) without transferring individual-level genotypes. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic software in the presence of admixture. By providing this resource, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people.