cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Far-Infrared detection of neutral atomic oxygen toward the Horsehead Nebula
Creators: name: Goicoechea, Javier R.
name: Compiegne, Mathieu
name: Habart, Emilie
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first detection of neutral atomic oxygen (3P_1-3P_2 fine structure line at ~63um) toward the Horsehead photodissociation region (PDR). The cloud has been mapped with the Spitzer Space Telescope at far-IR (FIR) wavelengths using MIPS in the spectral energy distribution (SED) mode. The [OI]63um line peaks at the illuminated edge of the cloud at AV~0.1-0.5 (inward the gas becomes too cold and outward the gas density drops). The luminosity carried by the [OI]63um line represents a significant fraction of the total FIR dust luminosity (I_63/I_FIR~4x10^-3). We analyze the dust continuum emission and the nonlocal OI excitation and radiative transfer in detail. The observations are reproduced with a gas density of n_H~10^4 cm^-3 and gas and dust temperatures of T_k~100 K and T_d~30 K. We conclude that the determination of the OI 3P_J level populations and emergent line intensities at such ``low'' densities is a complex non-LTE problem. FIR radiative pumping, [OI]63um subthermal emission, [OI]145um suprathermal and even maser emission can occur and decrease the resulting [OI]63/145 intensity ratio. The Herschel Space Observatory, observing from ~55 to 672um, will allow us to exploit the diagnostic power of FIR fine structure lines with unprecedented resolution and sensitivity.
description: Accepted for publication in ApJ Letters (editorial corrections included)
Type I Planet Migration in Nearly Laminar Disks
Creators: name: Li, H.
name: Lubow, S. H.
name: Li, S.
name: Lin, D. N. C.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We describe 2D hydrodynamic simulations of the migration of low-mass planets ($\leq 30 M_{\oplus}$) in nearly laminar disks (viscosity parameter $α< 10^{-3}$) over timescales of several thousand orbit periods. We consider disk masses of 1, 2, and 5 times the minimum mass solar nebula, disk thickness parameters of $H/r = 0.035$ and 0.05, and a variety of $α$ values and planet masses. Disk self-gravity is fully included. Previous analytic work has suggested that Type I planet migration can be halted in disks of sufficiently low turbulent viscosity, for $α\sim 10^{-4}$. The halting is due to a feedback effect of breaking density waves that results in a slight mass redistribution and consequently an increased outward torque contribution. The simulations confirm the existence of a critical mass ($M_{cr} \sim 10 M_{\oplus}$) beyond which migration halts in nearly laminar disks. For $α\ga 10^{-3}$, density feedback effects are washed out and Type I migration persists. The critical masses are in good agreement with the analytic model of Rafikov (2002). In addition, for $α\la 10^{-4}$ steep density gradients produce a vortex instability, resulting in a small time-varying eccentricity in the planet's orbit and a slight outward migration. Migration in nearly laminar disks may be sufficiently slow to reconcile the timescales of migration theory with those of giant planet formation in the core accretion model.
description: 3 figures, accepted to ApJL
Book Review: The Arab Spring: An Essay on Revolution and Constitutionalism. By Antoni Abat i Ninet and Mark Tushnet.
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 2016
Subjects: Revolutions
Constitutional law
Social change.

description: An American audience may not know Professor Ninet, but they surely are aware of Professor Tushnet, who has achieved the distinction of being both on the far left of the legal profession and on its more conservative front. In its earliest inception, Critical Legal Studies (“CLS”), as Gary Minda explains, attempted to recreate a ‘left intelligentsia’ in American law. Except for the legal realists of the thirties and forties, and a handful of sixties Marxists, there has never been a serious ‘leftist’ presence in American legal education. To establish a left intelligentsia in American law one would have to break free from the consensus orientation which has dominated American jurisprudence for this and much of the last century, and in fact of the century before that, too. To do this, CLS had to hold itself out as a ‘radical dissident movement within the legal academy. In the latter part of the twentieth century, Professor Tushnet was one of the CLS founding fathers, right there with Mort Horwitz and Duncan Kennedy. Since its high point, CLS has had many lives, much like South Parks’ Kenny character,1 but by now CLS largely rests in peace. But the conservative side of the American legal academe is flourishing, and Professor Tushnet is also well aware of this. In 2006, he served as co-editor of the Journal of Legal Education, which can only be called a centrist meeting-place.
In silico analysis of a putative dehalogenase from the genome of halophilic bacterium Halomonas smyrnensis AAD6T
Creators: name: Oyewusi, Habeebat Adekilekun
name: Akinyede, Kolajo Adedamola
name: Wahab, Roswanira Abdul
name: Huyop, Fahrul
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Microbial-assisted removal of natural or synthetic pollutants is the prevailing green, low-cost technology to treat polluted environments. However, the challenge with enzyme-assisted bioremediation is the laborious nature of dehalogenase-producing microorganisms’ bioprospecting. This bottleneck could be circumvented by in-silico analysis of certain microorganisms’ whole-genome sequences to predict their protein functions and enzyme versatility for improved biotechnological applications. Herein, this study performed structural analysis on a dehalogenase (DehHsAAD6) from the genome of Halomonas smyrnensis AAD6 by molecular docking and molecular dynamic (MD) simulations. Other bioinformatics tools were also employed to identify substrate preference (haloacids and haloacetates) of the DehHsAAD6. The DehHsAAD6 preferentially degraded haloacids and haloacetates (−3.2–4.8 kcal/mol) and which formed three hydrogen bonds with Tyr12, Lys46, and Asp182. MD simulations data revealed the higher stability of DehHsAAD6-haloacid- (RMSD 0.22–0.3 nm) and DehHsAAD6-haloacetates (RMSF 0.05–0.14 nm) complexes, with the DehHsAAD6-L-2CP complex being the most stable. The detail of molecular docking calculations ranked complexes with the lowest binding free energies as: DehHsAAD6-L-2CP complex (−4.8 kcal/mol) = DehHsAAD6-MCA (−4.8 kcal/mol) < DehHsAAD6-TCA (−4.5 kcal/mol) < DehHsAAD6-2,3-DCP (−4.1 kcal/mol) < DehHsAAD6-D-2CP (−3.9 kcal/mol) < DehHsAAD6-2,2-DCP (−3.5 kcal/mol) < DehHsAAD6-3CP (−3.2 kcal/mol). In a nutshell, the study findings offer valuable perceptions into the elucidation of possible reaction mechanisms of dehalogenases for extended substrate specificity and higher catalytic activity. Communicated by Ramaswamy H. Sarma
Academic Law Libraries and Scholarship: Communication, Publishing, and Ranking
Creators: Neacsu, Dana
Donovan, James
Publisher: name: Columbia University
Year: 2020
Subjects: Law libraries
Academic libraries--Publishing
Scholarly publishing
Law schools

description: We argue that the increasing role of scholarly impact in determining a school’s status will provide a new opportunity for libraries to assume a critical institutional role behind its traditional support of scholarship and teaching. In practice, this increased role can evolve in a multitude of ways. Based on the data used here, a strong argument can be made in favor of each library taking charge of both their faculty scholarly impact and publication of its school’s journals. Based on the success story of Perma.cc, a good argument can be made in favor of creating a consortium supporting both these endeavors. Either way, our thesis is that libraries cannot confine themselves to the roles they played in the predigital era. Law faculties create scholarship, and law students decide how much of that scholarship is published in student-edited journals. Academic law libraries are best situated to publish those journals on the digital platforms that librarians curate. Libraries have evolved from hubs of information into nuclei of scholarship support through creative use of technology. Law schools need us to streamline this process. Universities need us to start the long-due process of rethinking the libraries' role in the journal publishing enterprise.
Semi-regular continued fractions and an exact formula for the moments of the Minkowski question mark function
Creators: name: Alkauskas, Giedrius
Publisher: name: arXiv
Year: 2009
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: Primary: 11A55, 26A30, 11F67, Secondary: 33C10

description: This paper continues investigations on the integral transforms of the Minkowski question mark function. In this work we finally establish the long-sought formula for the moments, which does not explicitly involve regular continued fractions, though it has a hidden nice interpretation in terms of semi-regular continued fractions. The proof is self-contained and does not rely on previous results by the author.
description: 8 pages
Search for Neutrinos from GRB 080319B at Super-Kamiokande
Creators: name: Kamiokande Collaboration
name: Thrane, E.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We perform a search for neutrinos coincident with GRB 080319B, the brightest GRB observed to date, in a +/- 1,000 s window. No statistically significant coincidences were observed and we thereby obtain an upper limit on the fluence of neutrino-induced muons from this source. From this we apply reasonable assumptions to derive a limit on neutrino fluence from the GRB.
description: Accepted for publication in ApJ, May 2009 issue. 10 pages, 1 figure, 3 tables
Assessing three-dimensional soft tissue changes and the prediction of hard tissue changes after orthognathic surgery with a novel digital workflow
Creators: name: Ho, Jeremy Ka Chun
Publisher: name: University of British Columbia
Year: 2023

description: Objectives: To investigate the application of virtual surgical planning (VSP) for three-dimensional (3D) hard and soft tissue assessment in orthognathic patients with a novel digital workflow. Methods: Twenty-one consecutively treated pre-surgical patients were selected from two private oral surgeon’s offices. Soft tissue scans of the face with the Artec Space Spider and intra-oral scans, were taken one month before surgery (T0), then two months (T1), and six months (T2) after orthognathic surgery. Cone beam CTs (CBCTs) were taken only at T0 and T1. Serial 3D soft tissue region and landmark changes were assessed by root mean square (RMS) after superimposing the T1 and T2 scans over T0 in Geomagic Control X software, separately. The achieved hard tissue landmark changes were assessed and compared with the VSP three-dimensionally. The correlation of hard and soft tissue changes was also tested with correlation coefficient tests. The differences in soft and hard tissue changes between the Invisalign® clear aligner and fixed appliances samples were also compared with two sample-independent t-tests. Results: The Artec Space Spider captured soft tissue images with the same accuracy as CBCT. This digital workflow was accurate, repeatable, and reproducible. From two to six months after surgery, there was clinically significant soft tissue relapse of maxillary (16-69%) and mandibular (9-36%) regions and landmarks which were highly variable and asymmetrical. Predicted virtual surgical movements were highly accurate (5-15%) for hard tissue landmarks. Ratios of soft tissue to hard tissue changes measured in three dimensions two months following surgery were similar to findings in literature measured in two dimensions. There were generally no differences in changes in soft and hard tissue landmarks or VSP for fixed versus Invisalign patients. Conclusions: The Artec Space Spider can be used as part of a novel digital workflow for VSP. Clinicians and patients should have great confidence that VSP is highly accurate and applicable for both fixed and Invisalign cases. Additionally, clinically significant soft tissue relapse can be anticipated between two to six months after surgery.
A brief critique of the emaciated state and its reliance on non-governmental organizations to provide social services
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 2006
Subjects: subject: Law
subject: FOS: Law
subject: Political science
subject: FOS: Political science

description: When, in January 2006, seven-year-old Nixzmary Brown was tortured and beaten to death, allegedly by her stepfather as her mother ignored her cries for help, every New Yorker looked at the city's Administration for Children's Services for answers. Conversely, I do not recall any discussion about the failure of charities to adequately provide for the city's abused children. Charities, like non-governmental organizations (NGOs), are not expected to be responsible for systemic problems.  They are a moral and social bonus, which fill the gap in discrete areas where taxpayers' money is not sufficient. So I may be accused of having a one-track mind, but I cannot seem to escape the following questions: Why do we even talk about providing social services in the twenty-first century? Couldn't we have had this issue resolved by now? Why don't we have a “sophisticated national system of government departments” charged with this task? Most other Western countries have one. Even corporate America would like the government to be in charge of providing social services for its employees. Instead we find ourselves on the cutting-edge of a newly fashionable neo-liberal government that looks as emaciated as a Hollywood diva and as masculine as a New York City cop. This decade-long transformation comes hand-in-hand with a trend of privatization and an increased reliance on the nonprofit sector, both domestically and internationally
Immuno-informatics guided designing of a multi-epitope vaccine against Dengue and Zika
Creators: name: Bhardwaj, Aditi
name: Sharma, Ritika
name: Grover, Abhinav
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Dengue and zika are amongst the most prevalent mosquito-borne diseases caused by closely related members Dengue virus (DENV) and Zika virus (ZIKV), respectively, of the Flaviviridae family. DENV and ZIKV have been reported to co-infect several people, resulting in fatalities across the world. A vaccine that can safeguard against both these pathogens concurrently, can offer several advantages. This study has employed immuno-informatics for devising a multi-epitope, multi-pathogenic vaccine against both these viruses. Since, the two viruses share a common vector source, whose salivary components are reported to aid viral pathogenesis; antigenic salivary proteins from Aedes aegypti were also incorporated into the design of the vaccine along with conserved structural and non-structural viral proteins. Conserved B- and T-cell epitopes were identified for all the selected antigenic proteins. These epitopes were merged and further supplemented with β-defensin as an adjuvant, to yield an immunogenic vaccine construct. In-silico 3D modeling and structural validation of the vaccine construct was conducted, followed by its molecular docking and molecular dynamics simulation studies with human TLR2. Immune simulation study was also performed, and it further provided support that the designed vaccine can mount an effective immune response and hence provide protection against both DENV and ZIKV. Communicated by Ramaswamy H. Sarma
An imaging time-of-propagation system for charged particle identification at a super B factory
Creators: name: Nishimura, K.
name: Browder, T.
name: Hoedlmoser, H.
name: Jacobson, B.
name: Kennedy, J.
name: Rosen, M.
name: Ruckman, L.
name: Varner, G.
name: Wong, A.
name: Yen, W.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Super B factories that will further probe the flavor sector of the Standard Model and physics beyond will demand excellent charged particle identification (PID), particularly K/pi separation, for momenta up to 4 GeV/c, as well as the ability to operate under beam backgrounds significantly higher than current B factory experiments. We describe an Imaging Time-of-Propagation (iTOP) detector which shows significant potential to meet these requirements. Photons emitted from charged particle interactions in a Cerenkov radiator bar are internally reflected to the end of the bar, where they are collected on a compact image plane using photodetectors with fine spatial segmentation in two dimensions. Precision measurements of photon arrival time are used to enhance the two dimensional imaging, allowing the system to provide excellent PID capabilities within a reduced detector envelope. Results of the ongoing optimization of the geometric and physical properties of such a detector are presented, as well as simulated PID performance. Validation of simulations is being performed using a prototype in a cosmic ray test stand at the University of Hawaii.
description: 3 pages, 5 figures, submitted to TIPP09 proceedings
Advocacy as History? That Takes the Prize!
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 2004
Subjects: subject: Law--Methodology
subject: Legal briefs
subject: Law
subject: FOS: Law

description: "Gulag: A History", the recipient of the 2004 Pulitzer Prize for general non-fiction, may be particularly well received by lawyers and law students because they can appreciate author Anne Applebaum's writing skills. Gulag reads like a lawyer's product: a conclusion replete with facts and arguments. Those who enjoy perfecting their legal skills while reading for pleasure should read this review. Gulag is, in essence, a successful legal brief.
Microscopic calculation of the phonon dynamics of Sr$_{2}$RuO$_{4}$ compared with La$_{2}$CuO$_{4}$
Creators: name: Bauer, Thomas
name: Falter, Claus
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The phonon dynamics of the low-temperature superconductor Sr$_{2}$RuO$_{4}$ is calculated quantitatively in linear response theory and compared with the structurally isomorphic high-temperature superconductor La$_{2}$CuO$_{4}$. Our calculation corrects for a typical deficit of LDA-based calculations which always predict a too large electronic $k_{z}$-dispersion insufficient to describe the c-axis response in the real materials. With a more realistic computation of the electronic band structure the frequency and wavevector dependent irreducible polarization part of the density response function is determined and used for adiabatic and nonadiabatic phonon calculations. Our analysis for Sr$_{2}$RuO$_{4}$ reveals important differences from the lattice dynamics of $p$- and $n$-doped cuprates. Consistent with experimental evidence from inelastic neutron scattering the anomalous doping related softening of the strongly coupling high-frequency oxygen bond-stretching modes (OBSM) which is generic for the cuprate superconductors is largely suppressed or completely absent, respectively, depending on the actual value of the on-site Coulomb repulsion of the Ru4d orbitals. Also the presence of a characteristic $Λ_{1}$-mode with a very steep dispersion coupling strongly with the electrons is missing in Sr$_{2}$RuO$_{4}$. Moreover, we evaluate the possibility of a phonon-plasmon scenario for Sr$_{2}$RuO$_{4}$ which has been shown recently to be realistic for La$_{2}$CuO$_{4}$. In contrast to La$_{2}$CuO$_{4}$ in Sr$_{2}$RuO$_{4}$ the very low lying plasmons are overdamped along the c-axis.
description: 30 pages, 16 figures, 4 tables, 33 references
YUSUF XOS HOJIBNING "QUTADG'U BILIG" ASARIDA INSONDAGI IJOBIY FAZILATLAR UNI DOIMO KOMILLIK SARI YETAKLAYDI
Creators: name: Alimova Yayra Xotamovna. Mansurova Xurshida Soatovna Rahimova Iroda Madaminjon qizi    Qo'qon davlat pedagogika instituti boshlang'ich ta'lim fakulteti Fakultetlararo pedagogika va psixologiya kafedrasi o'qituvchisi
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada Yusuf Xos Hojibning "Qutadg'u bilig" asari insonda doimo komillikka yetaklovchi ijobiy fazilatlarga ega bo'lishi, uning tarbiyasiga doimo e'tibor qaratishi zarurligi ta'kidlangan. Bu, shuningdek, uyat, or-nomus, vatanparvarlik, xushmuomalalik, yaxshi niyat, kattalarga hurmat, bolalarga hurmat, o'z-o'zini hurmat qilish, ochiqlik, aql-zakovatni o'z ichiga oladi.
dono, bilimdon, xushmuomalalik kabi fazilatlar ta'kidlangan.
Kalit so'zlar: ezgulik, yetuklik, inson, tarbiya, uyat, or-nomus, vatanparvarlik, odob, xushmuomalalik, hurmat, izzat, ziyoli.
Electron- and neutrino-nucleus scattering from the quasielastic to the resonance region
Creators: name: Leitner, T.
name: Buss, O.
name: Alvarez-Ruso, L.
name: Mosel, U.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a model for electron- and neutrino-scattering off nucleons and nuclei focussing on the quasielastic and resonance region. The lepton-nucleon reaction is described within a relativistic formalism that includes, besides quasielastic scattering, the excitation of 13 N* and Delta resonances and a non-resonant single-pion background. Recent electron-scattering data is used for the state-of-the-art parametrizations of the vector form factors; the axial couplings are determined via PCAC and, in the case of the Delta resonance, the axial form factor is refitted using neutrino-scattering data. Scattering off nuclei is treated within the GiBUU framework that takes into account various nuclear effects: the local density approximation for the nuclear ground state, mean-field potentials and in-medium spectral functions. Results for inclusive scattering off Oxygen are presented and, in the case of electron-induced reactions, compared to experimental data and other models.
description: v2: misprints corrected; published in Phys. Rev. C
Book Review - Troubling Transparency: The History and Future of Freedom of Information. Edited by David E. Pozen and Michael Schudson. New York: Columbia University Press, 2018. Pp. viii, 341. ISBN: 9780231184984. US$90.00.
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Law
subject: FOS: Law
subject: Journalism
subject: Freedom of information

description: Troubling Transparency is a collection of essays written by jurists, sociologists, and journalists. The fourteen contributions to this volume were also presentations to the Columbia School of Journalism 2016 conference, which the co-editors, Michael Schudson and David Pozen also co-organized, celebrating the 50th Anniversary of the US Freedom of Information Act (FOIA). The essays are organized into four parts: 1) the history and conceptual foundations of the statute, 2) the impact FOIA has on the media, 3) tactics in transparency, and 4) the impact FOIA has had globally.
HST/WFPC2 observations of the LMC pulsar PSR B0540-69
Creators: name: Mignani, R. P.
name: Sartori, A.
name: De Luca, A.
name: Rudack, B.
name: Slowikowska, A.
name: Kanbach, G.
name: Caraveo, P. A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The study of the younger, and brighter, pulsars is important to understand the optical emission properties of isolated neutron stars. PSRB0540-69, the second brightest (V~22) optical pulsar, is obviously a very interesting target for these investigations. The aim of this work is threefold: constraining the pulsar proper motion and its velocity on the plane of the sky through optical astrometry, obtaining a more precise characterisation of the pulsar optical spectral energy distribution (SED) through a consistent set of multi-band, high-resolution, imaging photometry observations, measuring the pulsar optical phase-averaged linear polarisation, for which only a preliminary and uncertain measurement was obtained so far from ground-based observations. We performed high-resolution observations of PSRB0540-69 with the WFPC2 aboard the HST, in both direct imaging and polarimetry modes. From multi-epoch astrometry we set a 3sigma upper limit of 1 mas/yr on the pulsar proper motion, implying a transverse velocity <250 km/s at the 50 kpc LMC distance. Moreover, we determined the pulsar absolute position with an unprecedented accuracy of 70 mas. From multi-band photometry we characterised the pulsar power-law spectrum and we derived the most accurate measurement of the spectral index (0.70+/-0.07) which indicates a spectral turnover between the optical and X-ray bands. Finally, from polarimetry we obtained a new measurement of the pulsar phase-averaged polarisation degree (16+/-4%),consistent with magnetosphere models depending on the actual intrinsic polarisation degree and depolarisation factor, and we found that the polarisation vector (22+/-12deg position angle) is possibly aligned with the semi-major axis of the pulsar-wind nebula and with the apparent proper motion direction of its bright emission knot.
description: 14 pages, 12 figures, accepted for publication in Astronomy & Astrophysics
Docking and molecular dynamics simulation for therapeutic repurposing in small cell lung cancer (SCLC) patients infected with COVID-19
Creators: name: Pingali, M. Shivapriya
name: Singh, Anirudh
name: Singh, Vishal
name: Sahoo, Amaresh Kumar
name: Varadwaj, Pritish Kumar
name: Samanta, Sintu Kumar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Cancer care has become a challenge with the current COVID-19 pandemic scenario. Specially, cancers like small cell lung cancers (SCLC) are difficult to treat even in the normal situation due to their rapid growth and early metastasis. For such patients, treatment can’t be compromised and care must be taken to ensure their minimum exposure to the ongoing spread of COVID-19 infection. For this reason, in-house treatments are being suggested for these patients. Another issue is that symptoms of SCLC match well with that of COVID-19 infection. Hence, the detection of COVID-19 may also get delayed leading to unnecessary complications. Thus, we have tried to investigate if the therapeutics that is currently used in lung cancer treatment can also act against SARS-CoV-2. If it is so, the same treatment protocols can be continued even if the SCLC patient had contracted COVID-19 without compromising the cancer care. For this, RNA dependent RNA polymerase (RdRP) from SARS-CoV-2 has been selected as drug target. Both docking and molecular dynamicssimulation analysis have indicated that Paclitaxel and Dacomitinib may be explored as multi-target drugs for both SCLC and COVID-19. Communicated by Ramaswamy H. Sarma
Dyadic Green's functions and electromagnetic local density of states
Creators: name: Narayanaswamy, Arvind
name: Chen, Gang
Publisher: name: arXiv
Year: 2009
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: A formal proof to relate the concept of electromagnetic local density of states (LDOS) to the electric and magnetic dyadic Green's functions is provided. The expression for LDOS is obtained by relating the electromagnetic energy density at any location in a medium at uniform temperature $T$ to the electric and magnetic dyadic Green's functions. With this the concept of LDOS is also extended to material media. The LDOS is split into two terms -- one that originates from the energy density in an infinite, homogeneous medium and the other that takes into account scattering from inhomogenieties. The second part can always be defined unambiguously, even in lossy materials. For lossy materials, the first part is finite only if spatial dispersion is taken into account.
description: 20 pages, 1 figure
Additional file 1 of Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial
Creators: name: Wu, Jingsong
name: He, Youze
name: Liang, Shengxiang
name: Liu, Zhizhen
name: Huang, Jia
name: Liu, Weilin
name: Tao, Jing
name: Chen, Lidian
name: Chan, Chetwyn C. H.
name: Lee, Tatia M. C.
Publisher: name: figshare
Year: 2023
Subjects: Biochemistry
Medicine
Cell Biology
Neuroscience
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mental Health

description: Additional file 1: Figure S1. The workflow of this study. Table S1. Descriptions of the 11 modules of the computerized cognitive training (CCT) program. Table S2. for the comparison of group differences in the baseline SC-FC couplings. Table S3. For the comparison of group differences in the head motion parameters. Table S4. For the comparison of group differences in the functional global topology. Table S5. For the comparison of group differences in the structural global topology. Table S6. For the comparison of differences in network coupling selected according to MoCA scores. Table S7. For the comparison of differences in network coupling that were selected according to scores of the CAVLT immediate recall test. Table S8. For the comparison of differences in network coupling that were selected according to scores of the CAVLT delayed recall test. Table S9. For the comparison of differences in network coupling that were selected according to scores of the Rey CFT recall test.
An Eco-esc Pendulum of Copyright
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 1994
Subjects: subject: Law
subject: FOS: Law
subject: Copyright
subject: Education
subject: Copyright--Music

description: The thesis of this paper is neither new, nor subtle. It has, in fact, been a recurrent theme in many writings concerned with the interests in copyright and their effects in the present world. My LLM student concern was with the perversion of domestic copyright provisions from an incentive for learning and progress - within whatever limits that goal was fairly found in the statute and case decisions - into an insurmountable international obstacle to learning and education. Unfortunately, this 1993/4 LLM thesis remains as actual today as it was then.
Book Review - Comparative Legal History. Edited by Olivier Moréteau, Aniceto Masferrer, and Kjell A. Modéer. Cheltenham, UK; Northampton, MA: Edward Elgar Publishing, 2019. Pp. xiv, 512. ISBN 978-1-78195-521-5. UK£195.00; US$290.00.
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Law
subject: FOS: Law
subject: Comparative law
subject: Jurisprudence

description: Comparative Legal History stands out for both its content and its execution. At a time when most law schools devote themselves to the study of hic et nunc (here and now), Comparative Legal History proves there is something more than the rather dogmatic and pragmatic description of what is traditionally recognized as the law. In an age of hyper specialization, it discredits the absurd notion of law as (hard) science. Law, a human product, can easily be the object of scientific observations, but does that scientific observation need to be limited to the study of rules and norms in force and the way they are processed and applied hic et nunc?
Monitoring the interactions between bovine serum albumin and ZnO/Ag nanoparticles by spectroscopic techniques
Creators: name: Udnoor, Abhishek
name: Lokolkar, Manjunath
name: Yallur, Basappa C.
name: Kale, Raju
name: Kalasad, Muttanagoud N.
name: Katrahalli, Umesha
name: Manjunatha, Devagondanahalli H.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Computational Biology

description: Inducing the bio-functionalization in noble metal nanoparticles like gold, silver, zinc is very important to accomplish their biocompatibility in biological activities. These metal nanoparticles are being rigorously used in bio-sensing tools keeping their remarkable properties in mind. Amongst the serum albumins, the most ample proteins in plasma are bovine serum albumin and human serum albumin. A broad variety of physiological functions of bovine serum albumin has made it a model protein for bio-functionalization. In the present study, ZnO/Ag nanoparticles were synthesized and characterized by SEM and XRD techniques and the interaction between bovine serum albumin and ZnO/Ag nanoparticles was evaluated by employing ultra-violet, steady state fluorescence, circular dichroism and FTIR spectroscopic techniques. Upon the excitation of bovine serum albumin, ZnO/Ag nanoparticles appreciably reduced the intrinsic fluorescence intensity of bovine serum albumin. The number of binding locations and apparent binding constants at different temperatures were calculated by the fluorescence quenching method. Static mechanism of quenching and conformational modifications in bovine serum albumin were also found. Communicated by Ramaswamy H. Sarma
Supplementary Material from Understanding components of mobility during the COVID-19 pandemic
Creators: name: Edsberg Møllgaard, Peter
name: Lehmann, Sune
name: Alessandretti, Laura
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: 10399 Numerical and Computational Mathematics not elsewhere classified
subject: FOS: Mathematics
subject: 80201 Analysis of Algorithms and Complexity
subject: FOS: Computer and information sciences

description: Supplementary Text, Figures and Tables
On the Spectral Index of Distant Radio Galaxies
Creators: name: Verkhodanov, O. V.
name: Khabibullina, M. L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The problems of using the spectral index of radio galaxies in various tests, in particular, in selecting distant radio sources are considered. The history of the question of choosing a criterion of searching for distant radio galaxies based on the spectral index is presented. For a new catalog of 2442 radio galaxies constructed from NED, SDSS, and CATS data, an analytical form of the sp ectral index.redshift relation has been determined for the first time. The spectral index.angular size and spectral index.flux density diagrams have also been constructed. Peculiarities of the distribution of sources on these diagrams are discussed.
description: 7 pages,5 figures
Adaptive Robot Mediated Upper Limb Training Using Electromyogram Based Muscle Fatigue Indicators
Creators: name: Thacham-Poyil, Azeemsha
name: Steuber, Volker
name: Amirabdollahian, Farshid
Publisher: name: University of Hertfordshire
Year: 2019
Subjects: Robot
Electromyogram

description: Electromyogram Data from Upper Limb Muscles and Kinematic Data During Adaptive Robotic Interactions: The data set consists of kinematic and EMG signals collected from 3 upper limb muscles (Biceps Brachii, Anterior Deltoid, and Middle Deltoid) of healthy participants during an adaptive robotic interaction involving rowing movements. 30 (17 males, 13 females) healthy participants of at least 18 years old with no history of injury to the upper limb and back were involved in this experiment. Participants were students or staff members of University of Hertfordshire or other volunteers from outside the university. The measurements were taken using an EMG acquisition device (g.USBamp amplifier) from g.tec medical engineering GmbH. The data acquisition parameters (sampling rate, channel selection and so on) of the device were configured using Simulink. Three EMG electrode channels were configured in bipolar mode with a sampling frequency of 1200Hz. EMG electrodes for Biceps Brachii muscles were connected to Ports 11-12 of g.USBamp, Frontal Deltoid muscles to Ports 13-14 and Middle Deltoid muscles to Ports 15-16. The tasks involved upper limb exercise, which simulated rowing, using a robot arm (HapticMaster robot) as directed by visual instructions on screen and audio cues. This involved moving a robotic end-effector, while an animated boat rowing environment running in front of the participant on an LCD monitor. There were be 3 groups of participants in this study. Group A participants did not receive any adaptation from the robot during the interaction and were given break periods at regular intervals. Group B interacted with the adaptive robotic environment, which was designed to adjust the difficulty level of the training exercise based on EMG based fatigue indicators. Group C participants had a similar environment as Group B, but the environment only adapted based on the subject-reported fatigue. The participants were asked to continue the exercise until they felt very tired or until they reported fatigue 3 times or until the maximum feasible robotic resistance was reached.
Agribusiness Supply Chain Management through Digital Innovation: Sustainability versus Traceability
Creators: name: Sabrina Spallini
Publisher: name: Zenodo
Year: 2023
Subjects: Blockchain; Supply-chain; Sustainability; Agribusiness

description: Blockchain technology is considered as a type of disruptive technology and as one of the first tools of Industry 4.0 today.
It evolves in its applications and its characteristics adapt to increasingly diverse business processes, from cryptocurrency to business transactions, from supply chain control to customer communication. Its adoption by companies has led to profound changes in their business models.
Blockchain can be a strategic lever in the agri-food supply chain to reduce food waste and increase awareness of what is consumed, as higher quality products have a positive impact on consumers' health and quality of life.
The aim of this research is to analyse the use of blockchain in the traceability of the agri-food chain, in order to ensure transparency, provide a secure way to track and transfer resources through supply chains, and limit the risks of food fraud and safety.
It is important to bear in mind that its introduction is not just a technological innovation. It is a real business model that affects the whole life of a company and is used in different production sectors. It increases the effectiveness and efficiency of a company's sustainability policy and helps even smaller companies to communicate directly with all actors in the production chain.
To demonstrate these hypotheses, we will use representative case studies located in the Puglia region.The companies will be treated as best practices, because thanks to these technologies they have been able to innovate their products and expand their markets at national and international level.
The HERA challenges for LHC
Creators: name: Abramowicz, Halina
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Over the last two decades, the HERA collider has provided a large amount of new information about QCD dynamics at high energy. While the most appreciated are the measurements of the proton structure functions in a wide range of parton momentum x and virtuality Q^2, it is hard to believe that some of the observations at HERA which do not fit the simple picture of DGLAP dynamics would not get amplified at the LHC, possibly rendering certain approaches to searches beyond the Standard Model inadequate.
description: 19 pages, 15 figures, Talk presented at the 2009 Epiphany meeting, Cracow, Jan 5-7, 2009, dedicated to the memory of Jan Kwiecinski
Euprepes maculilabris Gray liz. aut. sp. alf.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Squamata
Sauria
Scincidae
Euprepes

description: * Euprepes (maculilabris Gray liz. aut. sp. alf.?)
Goldküste v. H. Dr. Mähly. [1]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 706, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
CLS stands for critical legal studies, if anyone remembers
Creators: Neacsu, Dana
Publisher: name: Columbia University
Year: 2000
Subjects: subject: Law
subject: FOS: Law

description: Critical Legal Studies (“CLS”), which started as a Left movement within legal academia, has undergone so many changes, that one may liken it to products of pop culture, such as the television cartoon show, South Park. South Park features a character named Kenny, totally unlike any other cartoon hero, tragic or otherwise. Like Kenny, who is an outsider and who speaks a language unintelligible to all except, astonishingly, his classmates, CLS no longer seems to possess a voice comprehensible to anyone outside its own small circle. Kenny, unlike all other cartoon figures, dies in every episode. Significantly, often Kenny's death has been self-inflicted--though not necessarily intentional--when, for instance, he ignores warnings of imminent danger. Like Kenny, CLS has suffered many often self-inflicted injuries. Like South Park, generally, CLS is certainly colorful, but often little more than that and, as in the cartoon, except for the certainty of Kenny's death and later resurrection, there seems more flash than substance in its existence. We are left to guess whether CLS will prove to be as resilient after apparent death, as Kenny.
Typical state of an isolated quantum system with fixed energy and unrestricted participation of eigenstates
Creators: name: Fine, Boris V.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chaotic Dynamics (nlin.CD)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This work describes the statistics for the occupation numbers of quantum levels in a large isolated quantum system, where all possible superpositions of eigenstates are allowed, provided all these superpositions have the same fixed energy. Such a condition is not equivalent to the conventional micro-canonical condition, because the latter limits the participating eigenstates to a very narrow energy window. The statistics is obtained analytically for both the entire system and its small subsystem. In a significant departure from the Boltzmann-Gibbs statistics, the average occupation numbers of quantum states exhibit in the present case weak algebraic dependence on energy. In the macroscopic limit, this dependence is routinely accompanied by the condensation into the lowest energy quantum state. This work contains initial numerical tests of the above statistics for finite systems, and also reports the following numerical finding: When the basis states of large but finite random matrix Hamiltonians are expanded in terms of eigenstates, the participation of eigenstates in such an expansion obeys the newly obtained statistics. The above statistics might be observable in small quantum systems, but for the macroscopic systems, it rather reenforces doubts about self-sufficiency of non-relativistic quantum mechanics for justifying the Boltzmann-Gibbs equilibrium.
description: 20 pages, 3 figures
Application of machine learning techniques for the quantification of myelin ultra-structure in transmission electron micrographs of the rat spinal cord
Creators: name: Holmes, Nathan
Publisher: name: University of British Columbia
Year: 2023

description: Assessing the morphology of myelin in transmission electron micrograph (TEM) images is an important research tool for studying certain neuropathologies and neuroregeneration. Additionally, TEM can be used to validate the accuracy of other methods of measuring the state of myelin as it allows direct visualization of myelin ultra-structure. Often this requires laborious manual quantification of TEM micrographs to extract useful morphological data, especially in cases where the feature of interest is not commonly measured such that software is not commercially available to aid in quantification. A recent study produced by our lab involved comparing measurements of myelin based on magnetic resonance imaging (MRI) T2 relaxation with TEM images in conditions of healthy and degenerating myelin in the rat spinal cord following a dorsal column transection injury. The MRI T2 techniques can quantify the amount of water trapped between layers of the myelin sheaths, as opposed to water in other spaces in healthy tissue. However, what the MRI T2 measurement was actually corresponding to in degenerating tissue was unknown. The TEM portion of this analysis involved manually tracing the area of the myelin sheath, and thresholding the image to separate intact myelin from vacuous spaces occurring in the myelin as it degenerates. This made it possible to determine that the MRI T2 technique only measures to the quantity of intact myelin in degenerating tissue. This thesis uses the TEM images and the manually quantified intact myelin measurements as data-sets for training machine learning approaches to automate this task. Three approaches are trained and evaluated: a k-nearest neighbour (KNN) approach based on natural clustering of image histograms, a standard SegNet deep-learning artificial neural network, and a more generic dense prediction artificial neural network featuring skip-connections to preserve low level data. The KNN approach was found to be completely unsuitable for the task. The SegNet approach had substantial difficulties which indicate that it did not have the flexibility to fully learn the data-set. Finally, the generic dense prediction network performed robustly in both the training and test data-sets. Additional testing is performed to contrast the performance of the two artificial neural networks.