cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rethinking teacher preparation: Conceptualizing skills and knowledge of novice teachers of secondary mathematics
Creators: name: Cummings, Margarita Borelli
Publisher: name: University of Utah
Year: 2019
Subjects: Mathematics education
Teacher education
Secondary education

description: This dissertation examines the extent to which novice secondary mathematics teachers (licensed and currently teaching in Utah) perceive they are prepared to do the work of teaching secondary mathematics. It first examined if novice secondary mathematics teachers' perceptions of their knowledge and skills of doing their work fell into four conceptualized domains: pedagogical knowledge, mathematical knowledge, pedagogical content knowledge, and curricular knowledge. Then it examined the extent to which novice teachers felt prepared do their work and where they perceived they gained their skills (in college or outside of college). Finally, it examined if novice teachers from different preparation programs in Utah reported a difference in their perceptions of preparedness. An exploratory factor analysis of the survey instrument used for the research indicated that novice teacher perceptions of their knowledge and skills did indeed fall into the four conceptualized domains. Analysis of the data also revealed that novice teachers felt most prepared in the domain of mathematical knowledge and least in the domain of pedagogical knowledge, with their perceptions of preparedness in the domains of pedagogical content knowledge and curricular knowledge between mathematical and pedagogical knowledge. Teachers also reported that they gained their mathematical and pedagogical knowledge both in and out of college, but that they gained their pedagogical content knowledge and curricular knowledge primarily outside of college. Novice teachers in the sample did not report a difference in their perceptions of preparedness in any of the domains by institution in which they were prepared. Findings from the study point to a need to rethink teacher preparation in secondary mathematics.
A Detached Protostellar Disk around a $\sim$0.2$M_{\odot}$ protostar in a Possible Site of a Multiple Star Formation in a Dynamical Environment in Taurus
Creators: name: Tokuda, Kazuki
name: Onishi, Toshikazu
name: Saigo, Kazuya
name: Hosokawa, Takashi
name: Matsumoto, Tomoaki
name: Inutsuka, Shu-ichiro
name: Machida, Masahiro N.
name: Tomida, Kengo
name: Kunitomo, Masanobu
name: Kawamura, Akiko
name: Fukui, Yasuo
name: Tachihara, Kengo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report ALMA observations in 0.87 mm continuum and $^{12}$CO ($J$ = 3--2) toward a very low-luminosity ($
description: 9 pages, 4 figures, accepted for publication in The Astrophysical Journal
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00359
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00359, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Relative timing based verification and design with delay insensitive signal path modeling with application for field programmable gate arrays
Creators: name: Manoranjan, Jotham Vaddaboina
Publisher: name: University of Utah
Year: 2019
Subjects: Applied sciences
Asynchronous circuits
FPGAs

description: The relative timing (RT) based asynchronous design methodology has been successfully used to create application specific integrated circuit (ASIC) designs that are a process generation ahead of their synchronous counterparts in terms of power, performance and energy. However, while the implementation of RT asynchronous circuits has been dealt with successfully in the ASIC domain, there has been limited exploration of utilizing the design methodology on field programmable gate arrays (FPGAs). This dissertation seeks to address the challenges in implementing RT asynchronous circuits on FPGAs. Relative Timing uses path-based timing constraints to guarantee that a circuit conforms to its behavioral specification. A methodology for the design of glitch free burstmode asynchronous controllers on FPGAs is presented. Path based timing constraints are implement to ensure circuit functionality. A flow for the modeling of the circuit, extraction of relative timing constraints, and implementation of the extracted constraints is presented. Optimizations that enable faster implementation and more robust designs are discussed. The dissertation also presents a framework to evaluate and rank relative timing constraint sets for a given circuit. Multiple constraint sets are possible for a single circuit. The constraint sets are evaluated on the basis of robustness of the constraints and conflicts between constraints in the same set. The methodology is used to optimize the extraction of relative timing constraints. An FPGA architecture capable of relative timing based digital implementations is designed. Modifications are made to a traditional synchronous FPGA architecture to make it asynchronous capable, while retaining its capability as a fully functional synchronous FPGA. A Microprocessor without Interlocked Pipeline Stages (MIPS) design is used to test the FPGA. A performance improvement of 1.7x and a power improvement of 2.3x is achieved. Furthermore, a novel reconfigurable circuit capable of implementing the entire family of 2-phase and 4-phase latch protocols is presented. The circuit is implemented on the International Business Machine Artisan 65nm node and its performance is compared with implementations on a Xilinx Virtex-5 chip that is manufactured on a similar node. A 4x improvement in speed and 2.7x improvement in energy per cycle is achieved.
Reimagining the West
Creators: name: Stack, Jasmine
Publisher: name: University of Utah
Year: 2019
Subjects: Folklore
Dance
Sustainability

description: Using sensory stimuli, creative movement practices, invented creatures, and immersive performance, this dance research presents a reimagined view of the desert landscapes that have come to be known within North American cultural discourse as "The West." The research draws influence from both the author's history as a Euro-American woman growing up in the Southwestern desert, and from her experiences with various North American Indigenous groups, analyzing the differing perspectives of landscape that exist in these two cultural demographics. It examines the influence of North American settler colonialism on contemporary Western views of desert landscapes as wastelands, and the ways in which Indigenous perspectives are counteracting this effect. This written work includes reflections on Reimagining the West, an evening-length dance performance choreographed by the author that presented audiences with a reimagined perspective of desert landscape, embedded with imagery, imagination, mythology, and symbolism. The creative physical and theoretical research of this thesis offers a new understanding of desert spaces and the role of the dancing body in preserving them, arguing for its effectiveness in inspiring individuals to coexist sustainably with natural landscapes.
Lepton acceleration in the vicinity of the event horizon: Very-high-energy emissions from super-massive black holes
Creators: name: Hirotani, Kouichi
name: Pu, Hung-Yi
name: Lin, Lupin Chun-Che
name: Kong, Albert K. H
name: Matsushita, Satoki
name: Asada, Keiichi
name: Chang, Hsiang-Kuang
name: Tam, Pak-Hin T.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Around a rapidly rotating black hole (BH), when the plasma accretion rate is much less than the Eddington rate, the radiatively inefficient accretion flow (RIAF) cannot supply enough MeV photons that are capable of materializing as pairs. In such a charge-starved BH magnetosphere, the force-free condition breaks down in the polar funnels. Applying the pulsar outer-magnetospheric lepton accelerator theory to super-massive BHs, we demonstrate that a strong electric field arises along the magnetic field lines in the direct vicinity of the event horizon in the funnels, that the electrons and positrons are accelerated up to 100~TeV in this vacuum gap, and that these leptons emit copious photons via inverse-Compton (IC) process between 0.1~TeV and 30~TeV for a distant observer. It is found that these IC fluxes will be detectable with Imaging Atmospheric Cherenkov Telescopes, provided that a low-luminosity active galactic nucleus is located within 1~Mpc for a million-solar-mass central BH or within 30~Mpc for a billion-solar-mass central BH. These very-high-energy fluxes are beamed in a relatively small solid angle around the rotation axis because of the inhomogeneous and anisotropic distribution of the RIAF photon field, and show an anti-correlation with the RIAF submillimeter fluxes. The gap luminosity little depends on the three-dimensional magnetic-field configuration, because the Goldreich-Julian charge density, and hence the exerted electric field is essentially governed by the frame-dragging effect, not by the magnetic field configuration.
description: 15 pages, 16 figures; Accepted for publication in the Astrophysical Journal. arXiv admin note: text overlap with arXiv:1610.07819
On the new short orbital period cataclysmic variable Halpha0242-2802
Creators: name: Mason, E.
name: Howell, S. B.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present results from our phase-resolved spectroscopy of the newly identified cataclysmic variable Halpha0242-2802. Halpha0242-2802 was identified from a deep UK Schmidt Halpha-R band survey as a candidate cataclysmic variable. Although initial spectroscopy revealed an optical spectrum very similar to that of the famous short orbital period system WZ Sge, the analysis of our data shows that this is not the case. Halpha0242-28 differs from WZ Sge in both the accretion disk structure and the orbital period. In particular, Halpha0242-28 appears to be a system which has not reached the orbital period minimum, yet.
description: 9 pages, 6 figures. In press
title: Expanding Access in Massachusetts: Inclusive Education for Students with Intellectual Developmental Disabilities and Autism Spectrum Disorder
Creators: name: Jarzabski, Kerri
Publisher: name: University of Massachusetts Amherst
Year: 2023
Subjects: subject: Disability and Equity in Education
subject: Higher Education

description: This brief is one in a series aimed at providing higher education policymakers and advocates with an evidence base to address how to best serve students in light of the challenges facing higher education. This brief was authored by a University of Massachusetts Amherst student as a course assignment for EDUC 674B: Higher Education Policy and was reviewed for accuracy by Professor Ryan Wells.
Enhancing the Understanding of Knowledge Management Process in Global Organizations: A Process-Based Approach
Creators: name: KOWSHIK, SK TASTHEKUR HOSSAIN
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 350799
subject: Strategy, management and organisational behaviour not elsewhere classified
classificationCode: 350709
subject: Organisation and management theory

description: In recent years, organizations have recognized knowledge as a crucial asset, adopting strategies to preserve it for the future. Justifying resource allocation for knowledge management (KM) initiatives remains a challenge. This thesis comprises three papers to enhance understanding of KM. Paper 1 analyzes KM literature evolution, identifying 11 key research themes, offering a holistic view. Paper 2 focuses on KM processes, especially knowledge transfer, revealing associations with learning, embeddedness, and innovation. Paper 3 explores KM process enablers and barriers in software development, emphasizing adaptability, structured storage, and leadership support. These papers offer comprehensive insights into KM dynamics, bridging gaps, and providing practical implications for academia and practitioners.
Cones, Spins and Heat Kernels
Creators: name: Fursaev, Dmitri V.
name: Miele, Gennaro
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The heat kernels of Laplacians for spin 1/2, 1, 3/2 and 2 fields, and the asymptotic expansion of their traces are studied on manifolds with conical singularities. The exact mode-by-mode analysis is carried out for 2-dimensional domains and then extended to arbitrary dimensions. The corrections to the first Schwinger-DeWitt coefficients in the trace expansion, due to conical singularities, are found for all the above spins. The results for spins 1/2 and 1 resemble the scalar case. However, the heat kernels of the Lichnerowicz spin 2 operator and the spin 3/2 Laplacian show a new feature. When the conical angle deficit vanishes the limiting values of these traces differ from the corresponding values computed on the smooth manifold. The reason for the discrepancy is breaking of the local translational isometries near a conical singularity. As an application, the results are used to find the ultraviolet divergences in the quantum corrections to the black hole entropy for all these spins.
description: latex file, 27 pages
The role of hypoxia inducible factor 1 (HIF 1) in the radioresistance of meningiomas
Creators: name: Karsy, Michael A.
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Bioengineering
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Oncology

description: Meningiomas are the most common primary brain tumors, accounting for 36.6% of all tumors with ∼20,000 cases annually in the U.S. Although 65-80% of cases are benign (World Health Organization [WHO] Grade I), recurrence over a long period can be seen, especially for subtotal resections and higher-grade tumors (II and III). Radiotherapy is a common primary or adjuvant therapy, but its mechanisms of action in the setting of distinct subtypes of meningioma remain unknown. Hypoxia-inducible factor 1 (HIF1) plays a key role in cellular response to oxygen tension, modulates multiple downstream genes, controls tissue vascularization, and may serve as a resistance-promoting mechanism in tumors. The aim of this study was to evaluate the clinical impact of the HIF1-signaling pathway in meningioma characterization as well as the impact of radiotherapy on meningiomas in the setting of HIF1 knockout. Clinical samples from patients with meningiomas, primary derived cell lines (GAR, JEN, SAM, MCT, BSH, IOMM-LEE), and HIF1 generated knockouts (GAR-1589) were utilized. Multiple immunohistochemical markers and a fractal-based microvascularity quantification showed that Grade I meningiomas ≥3 cm showed greater staining for MIB and von Willebrand Factor as well as an average 19-month shorter survival. In addition, a MIB index ≥3 showed high specificity (82.5%) but not sensitivity (36%) for predicting progression-free survival. Cell proliferation and apoptosis in response to radiation doses depended on cell density, HIF1A mutational status, and oxygen tension. Higher plated densities of cells showed resistance to radiation for various primary meningioma cell lines. GAR cells demonstrated greater response to high-dose radiation than GAR-1589 cells in 2D and 3D cultures, while neither cell line responded to fractionated radiotherapy. Hypoxic environments reduced the efficacy of radiation, in fact showing increased cell proliferation with low doses of radiation. GAR-1589 cell, however, showed greater increases in cell apoptosis during radiotherapy in normoxic environments than GAR cells. Multimodal imaging using tumor bioluminescence, positron emission tomography tracers, and MRI showed potential for evaluating various characteristics of primary brain tumors noninvasively using an orthotopic rodent model. These results offer some correlation clinically and experimentally regarding the importance of HIF1 and tumor resistance.
Retroviral Capsid Recognition by the Host Restriction Factor TRIM5 Alpha
Creators: name: Chandrasekaran, Viswanathan
Publisher: name: University of Utah
Year: 2019

description: Mammalian hosts have evolved protein "restriction factors" to combat retroviruses. TRIM5α and the related TRIMCyp protein (collectively TRIM5), are restriction factors that can potently restrict retroviruses, including HIV-1, by binding their capsids and blocking reverse transcription. Previous studies have shown that the C-terminal SPRY/CypA domains of TRIM5 proteins bind the capsids of susceptible retroviruses and that higher-order oligomerization of TRIM5 proteins apparently also contributes to capsid binding. However, the biochemical and structural details of these interactions are not fully understood. To study how TRIM5 proteins recognize capsids, we have developed new methods for expressing and purifying recombinant TRIM5 proteins. Here, we report biochemical, electron microscopic and X-ray crystallographic studies of pure recombinant TRIM5 proteins and their complexes with authentic HIV-1 core particles and in vitro-assembled mimics of the HIV-1 capsid surface. In Chapter 2, we report the expression, purification and electron crystallographic studies of a restrictive, but non-native chimeric rhesus TRIM5 protein (TRIM5-21R), and show that TRIM5-21R can spontaneously self-assemble into paracrystalline hexagonal lattices comprising 6-sided rings. Moreover, ring assembly is promoted by TRIM5-21R binding to hexagonal HIV-1 CA assemblies. In Chapter 3, we report the first crystal structure of a TRIM coiled-coil domain (from human TRIM25) as well as supporting analytical ultracentrifugation and disulfide crosslinking experiments showing that other iv TRIM coiled-coils, including TRIM5, also form antiparallel dimers that are ~170 Å long. In Chapter 4, we describe the expression and purification of 11 different mammalian TRIM5 alleles. We demonstrate that TRIM5 hexagonal assembly is a conserved property and report electron microscopic and biochemical studies showing that TRIM5 proteins form a ~35 nm-spaced, flexible hexagonal "net" on the surface of decorated HIV-1 cores and other capsid mimics. In Chapter 5, I present my ongoing attempts to crystallize and determine the structure of the TRIM5α core domains in the assembled state. Taken together, my work supports a "pattern recognition" model for capsid recognition in which TRIM5 proteins have evolved to restrict a variety of different retroviruses by cooperatively assembling flexible hexagonal nets that can bind avidly and adapt to the symmetry, hexagonal spacing and curvature of retroviral capsids.
Exploring SMBH Assembly with Semi-analytic Modelling
Creators: name: Ricarte, Angelo
name: Natarajan, Priyamvada
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We develop a semi-analytic model to explore different prescriptions of supermassive black hole (SMBH) fuelling. This model utilises a merger-triggered burst mode in concert with two possible implementations of a long-lived steady mode for assembling the mass of the black hole in a galactic nucleus. We improve modelling of the galaxy-halo connection in order to more realistically determine the evolution of a halo's velocity dispersion. We use four model variants to explore a suite of observables: the M-sigma relation, mass functions of both the overall and broad-line quasar population, and luminosity functions as a function of redshift. We find that "downsizing" is a natural consequence of our improved velocity dispersion mappings, and that high-mass SMBHs assemble earlier than low-mass SMBHs. The burst mode of fuelling is sufficient to explain the assembly of SMBHs to z=2, but an additional steady mode is required to both assemble low-mass SMBHs and reproduce the low-redshift luminosity function. We discuss in detail the trade-offs in matching various observables and the interconnected modelling components that govern them. As a result, we demonstrate the utility as well as the limitations of these semi-analytic techniques.
description: Accepted by MNRAS October 30th, 2017. 18 pages, 12 figures, 2 tables
Reversible Inhibition of Lysine-Specific Demethylase 1 is a Novel Therapeutic Strategy for Solid Tumors
Creators: name: Theisen, Emily Rose
Publisher: name: University of Utah
Year: 2019

description: Cancer is a genomic disease driven by interplay between genetic and epigenetic factors. While genetic mutations are irreversible events, epigenetic regulation is dynamic and reversible, and small molecule blockade of the epigenetic machinery has shown clinical benefit in hematological malignancies. However, the promise of epigenetic therapy has yet to be realized in solid tumors due do limited efficacy and elevated risk of toxicity. Development of potent and specific inhibitors targeting the histone methylation machinery shows promise in tailoring epigenetic therapy for a specific malignancy and decreasing the risk of off-target effects. One such target of interest is the histone lysine-specific demethylase 1 (LSD1). Several solid malignancies show upregulation of LSD1 associated with an aggressive clinical course. Validation of LSD1 as a target has been limited by poorly potent and nonspecific tool compounds, hindering evaluation in in vivo models of disease. This work describes the discovery of a novel potent, specific, and reversible series of LSD1 inhibitors. The identified lead compound, HCI2509, is a noncompetitive inhibitor with nanomolar affinity for LSD1. HCI2509 impaired cell viability across several human cancer cell lines, with both Ewing sarcoma and endometrial cancers showing particularly potent responses. Ewing sarcoma is a rare and aggressive pediatric malignancy characterized by by the chromosomal translocation-derived EWS/ETS fusion proteins. EWS/ETS fusions act iv as oncogenic transcription factors and facilitate cellular reprogramming through the activation of oncogenes and repression of tumor suppressors. Treatment with HCI2509 reverses both EWS/ETS-mediated transcriptional activation and transcriptional repression, and leads to apoptotic cell death in Ewing sarcoma cells. Notably, HCI2509 shows single-agent efficacy in xenograft models of Ewing sarcoma and represents a new therapeutic strategy for this devastating disease. HCI2509 also shows single-agent efficacy in a xenograft model of Type II endometrial carcinoma. Cases of Type II endometrial carcinoma comprise 11% of the incidence and 48% of the deaths due to endometrial cancer annually, such that new therapies are needed for this aggressive subtype. Reversible LSD1 inhibition was associated with tumor regression in an orthotopic model of this disease. These results demonstrate the promise of targeting the histone methylation machinery, specifically LSD1, as a therapeutic strategy for solid tumors.
Study of the $e^+e^-\toηγ$ process with SND detector at the VEPP-2M $e^+e^-$ collider
Creators: name: Achasov, M. N.
name: Aulchenko, V. M.
name: Beloborodov, K. I.
name: Berdyugin, A. V.
name: Bogdanchikov, A. G.
name: Bozhenok, A. V.
name: Bukin, D. A.
name: Dimova, T. V.
name: Druzhinin, V. P.
name: Golubev, V. B.
name: Korol, A. A.
name: Koshuba, S. V.
name: Otboev, A. V.
name: Pakhtusova, E. V.
name: Serednyakov, S. I.
name: Shatunov, Yu. M.
name: Sidorov, V. A.
name: Silagadze, Z. K.
name: Skrinsky, A. N.
name: Vasiljev, A. V.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In experiment with the SND detector at VEPP-2M $e^+e^-$ collider the $e^+e^-\toηγ$ cross section was measured in the energy range $E$=0.60--1.38 GeV with the integrated luminosity of 27.8 pb$^{-1}$. The measured cross section is well described by the vector meson dominance model with contributions from the $ρ(770)$, $ω(783)$, $ϕ(1020)$, $ρ^{\prime}(1465)$ resonances and agrees with results of previous measurements. The decay probabilities $\BR(ϕ\toηγ)$, $\BR(ω\toηγ)$ and $\BR(ρ\toηγ)$ were measured with the accuracies better than or comparable to the world averages.
description: 13 pages, 6 figures, 5 tables
Measurement of the electric polarizability of lithium by atom interferometry
Creators: name: Miffre, Alain
name: Jacquey, Marion
name: Buchner, Matthias
name: Trenec, Gérard
name: Vigue, Jacques
Publisher: name: arXiv
Year: 2005
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We have built an atom interferometer and, by applying an electric field on one of the two interfering beams, we have measured the static electric polarizability of lithium with a 0.66 % uncertainty. Our experiment is similar to an experiment done on sodium in 1995 by D. Pritchard and co-workers, with several improvements: the electric field can be calculated analytically and our phase measurements are very accurate. This experiment illustrates the extreme sensitivity of atom interferometry: when the atom enters the electric field, its velocity increases and the fractional change, equal to 4 x 10^(-9) for our largest field, is measured with a 10^(-3) accuracy.
description: 4 pages, 15 June 2005
title: ADCO, Boursier de Cîteaux : comptes (1489-1493) (11 H 1166), f. 00375
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166), f. 00375, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Kondo lattice excitation observed using resonant inelastic X-ray scattering at the Yb $M_5$ edge
Creators: name: Hancock, Jason N.
name: Dzero, Maxim
name: Sarrao, John
name: Schmitt, Thorsten
name: Strocov, Vladimir N.
name: Guarise, Marco
name: Grioni, Marco
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a study of the resonant inelastic scattering response of \ybin\ excited at the tender Yb $M_5$ X-ray edge. In the high-temperature, paramagnetic phase, we observe a multiplet structure which can be understood at an ionic level. Upon cooling through the valence transition at $T_v\sim$ 40$K$, we observe a strong renormalization of the low-energy spectra, indicating a sensitivity to the formation of an intermediate valence phase at low temperatures. Similar spectrum renormalization has been observed in the optical conductivity, which suggests that the low-energy electronic structure possesses both mixed conduction and localized character.
description: 8 pages, 5 figures; submitted, Phys. Rev. B
The Role of Glucose and Fatigue in Cognitive Control and Sustained Attention: An Electroencephalographic Assessment
Creators: name: Coleman, James Richard
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Cognitive psychology
subject: Neurosciences
subject: FOS: Clinical medicine

description: Cognitive control mechanisms were examined through depletion and restoration manipulations common in self-regulation literature. In this within-subjects, double-blind placebo controlled experiment, 33 participants performed three blocks of a high-congruency version of the flanker task while their EEG signals were recorded. Cognitive fatigue was induced in participants by lengthy flanker blocks, and they received either glucose or a placebo so we could examine the effects of metabolic restoration. Overall, there was a main effect of cognitive fatigue on flanker accuracy and on error-related event related potentials (ERPs). Participants had more accurate responses in the third block of the flanker task when they drank glucose as compared to the placebo. Additionally, the error-related negativity (ERN) waveform increased in amplitude during the third block of the flanker task when participants drank glucose. These findings suggest that there is overlap between the bodies of literature on cognitive control and self-regulation, specifically when measuring the activity in the anterior cingulate cortex during conflict paradigms.
Energy dependent stereodynamics of the Ne($^3$P$_2$)+Ar reaction
Creators: name: Gordon, Sean D. S.
name: Zou, Junwen
name: Tanteri, Silvia
name: Jankunas, Justin
name: Osterwalder, Andreas
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The stereodynamics of the Ne($^3$P$_2$)+Ar Penning and Associative ionization reactions have been studied using a crossed molecular beam apparatus. The experiment uses a curved magnetic hexapole to polarise the Ne($^3$P$_2$) which is then oriented with a shaped magnetic field in the region where it intersects with a beam of Ar($^1$S). The ratios of Penning to associative ionization were recorded over a range of collision energies from 320 cm$^{-1}$ to 500 cm$^{-1}$ and the data was used to obtain $Ω$ state dependent reactivities for the two reaction channels. These reactivities were found to compare favourably to those predicted in the theoretical work of Brumer et al.
description: Phys. Rev. Lett
Reversibility and Kinetic Precipitation of Asphaltenes
Creators: name: Chaisoontornyotin, Wattana
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Chemical engineering
subject: FOS: Chemical engineering

description: Asphaltenes are one of the component fractions in crude oil and can destabilize due to a change of pressure, temperature, or composition. Destabilized asphaltenes can precipitate and deposit, causing numerous problems and challenges during oil production and processing such as plugging, fouling, and emulsion stability. Thermodynamic models were previously developed to investigate and predict the phase behavior of asphaltenes using experimental data that assumed the destabilized asphaltenes reach their equilibrium state immediately after changing system conditions. However, asphaltene precipitation has previously been shown to be a slow aggregation process suggesting that the previous thermodynamic models might be inaccurate and misrepresent the behavior of asphaltenes. Reversibility is a requirement for the application of equilibrium thermodynamics to predict the phase behavior of mixtures. In this work, asphaltene precipitation was found to be a reversible process, and the cause of the partial reversibility conclusion in previous work was discovered to be a neglected slow aggregation process. This finding reinforces the importance of a slow aggregation process as it shows that considering the kinetics can significantly alter the conclusions. The aggregation rates of asphaltenes have also previously been investigated and found that the aggregation rates of asphaltenes depend on thermodynamic driving forces. This study shows that asphaltene aggregation and deposition highly correlate with thermodynamic driving forces, but the deposit growth was governed by diffusion limitations. This investigation reveals that thermodynamic properties can directly investigate the asphaltene behavior, and the diffusion limitation finding can lead to developing a new and more accurate deposition model. In addition, for the first time, the presence of inorganic solids was observed to increase the rate of asphaltene precipitation. A model was developed to quantify the rate of asphaltene precipitation under different process conditions. This investigation leads to a clearer understanding of the complex asphaltene aggregation process that occurs in real and heterogeneous systems. The usages of inorganic solids as nucleation sites to remove unstable asphaltenes and decrease the asphaltene problems during the production are potentially possible. The findings from this dissertation emphasize the essentials of precipitation kinetics and provide ideas to decreases the asphaltene problems and understanding the behavior of asphaltenes using the thermodynamic properties.
LUTO, UM PROCESSO DE AUTOCUIDADO, RESILIÊNCIA E FÉ
Creators: name: KABARITI, Cleide Marques Cunha
Publisher: name: Zenodo
Year: 2024
Subjects: Luto
Morte
Fé
Auto Cuidado
Resiliência

description: Para quem sofreu perdas e busca entender as emoções que envolve esse momento assustador e desastroso, até o luto passar. Desenvolver resiliência, na certeza da impermanência
Cosmography, Decelerating Past, and Cosmological Models: Learning the Bayesian Way
Creators: name: John, Moncy V.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, using a significantly improved version of the model-independent, cosmographic approach to cosmology (John, M. V. 2004, ApJ, 614, 1), we address an important question: Was there a decelerating past for the universe? To answer this, the Bayes's probability theory is employed, which is the most appropriate tool for quantifying our knowledge when it changes through the acquisition of new data. The cosmographic approach helps to sort out the models in which the universe was always accelerating from those in which it decelerated for at least some time in the period of interest. Bayesian model comparison technique is used to discriminate these rival hypotheses with the aid of recent releases of supernova data. We also attempt to provide and improve another example of Bayesian model comparison, performed between some Friedmann models, using the same data. Our conclusion, which is consistent with other approaches, is that the apparent magnitude-redshift data alone cannot discriminate these competing hypotheses. We also argue that the lessons learnt using Bayesian theory are extremely valuable to avoid frequent U-turns in cosmology.
description: Accepted for publication in The Astrophysical Journal (ApJ)
Broadband Multizone Sound Rendering by Jointly Optimizing the Sound Pressure and Particle Velocity
Creators: name: Buerger, Michael
name: Hofmann, Christian
name: Kellermann, Walter
Publisher: name: arXiv
Year: 2017
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Sound (cs.SD)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: In this paper, a recently proposed approach to multizone sound field synthesis, referred to as Joint Pressure and Velocity Matching (JPVM), is investigated analytically using a spherical harmonics representation of the sound field. The approach is motivated by the Kirchhoff-Helmholtz integral equation and aims at controlling the sound field inside the local listening zones by evoking the sound pressure and particle velocity on surrounding contours. Based on the findings of the modal analysis, an improved version of JPVM is proposed which provides both better performance and lower complexity. In particular, it is shown analytically that the optimization of the tangential component of the particle velocity vector, as is done in the original JPVM approach, is very susceptible to errors and thus not pursued anymore. The analysis furthermore provides fundamental insights as to how the spherical harmonics used to describe the 3D variant sound field translate into 2D basis functions as observed on the contours surrounding the zones. By means of simulations, it is verified that discarding the tangential component of the particle velocity vector ultimately leads to an improved performance. Finally, the impact of sensor noise on the reproduction performance is assessed.
The Role of Caspase-2 and PIDD1 in Lung Tumorigenesis and Response to Genotoxic Stress
Creators: name: Terry, Matthew Robinson
Publisher: name: University of Utah
Year: 2019

description: Platinum-based chemotherapy is the standard-of-care for non-small cell lung cancer. As with other chemotherapies, not all patients respond positively to treatment and almost all patients will develop chemotherapy-resistant disease. Using the KrasG12D-driven mouse model of lung adenocarcinoma, our lab identified upregulation of p53-induced with a death domain isoform 1 (Pidd1) in resistant tumors in response to long-term cisplatin chemotherapy treatment. Remarkably, PIDD1 expression in vitro induces p53-dependent resistance to cisplatin as well as other DNA, damaging chemotherapeutics. PIDD1 expression leads to assembly of large molecular weight complexes named PIDDosomes. The Caspase-2-PIDDosome is critical for PIDD1-induced chemotherapy resistance. Our lab demonstrated that the Caspase-2-PIDDosome dynamically regulates p53 activity via proteolytic modification of MDM2, the master negative regulator of p53. In unstressed cells, MDM2 binds to and ubiquitinates p53, targeting it for proteasomal degradation. Upon stress, Pidd1 is upregulated, ultimately leading to formation of the Caspase-2-PIDDosome, and subsequent Caspase-2 activation. Activated Caspase-2 cleaves MDM2 into two fragments: p60 and p30. p60 maintains the ability to bind p53, but cannot ubiquitinate p53, resulting in increased p53 protein stability. The role of the Caspase-2-PIDDosome in regulating the p53-MDM2 feedback loop is not well characterized in tumorigenesis or chemotherapy response. In this study, I utilize the KrasG12D-driven mouse model of lung adenocarcinoma to investigate tumorigenesis and chemotherapy response in Caspase-2-deficient and Pidd1-deficient mice. These data demonstrate that Caspase-2 is a tumor suppressor in lung adenocarcinoma primarily by inhibiting cell proliferation. Caspase-2-deficient tumors respond to chemotherapy; however, rapid tumor cell proliferation following treatment reduces the long-term therapeutic efficacy of chemotherapy. Unexpectedly, Pidd1-deficiency does not impact lung tumorigenesis or chemotherapy response. Mechanistic investigation in vitro revealed that ATM phosphorylation of PIDD1 is critical for Caspase-2-PIDDosome assembly, Caspase-2-mediated MDM2 cleavage, cell cycle arrest, and resistance to DNA damaging agents. This pathway is not modulated by exogenous MDM2 or its cleavage product p60. Further, pharmacological inhibition of the p53-MDM2 negative feedback-loop using nutlin-3 does not alter PIDD1-induced growth arrest or cisplatin resistance. Together these findings demonstrate that Caspase-2 and PIDD1 have distinct functions in vivo and elucidate the Caspase-2-PIDDosome signaling network in p53-dependent response to DNA damage.
Role of Epigenetic Regulation in Human Sperm and Egg Analysis of DNA Methylation and PolyA Regulation
Creators: name: Pflüger, Christian
Publisher: name: University of Utah
Year: 2019

description: Our work focused on how germ cell DNA is packaged and if it is poised by distinctive chromatin to infl uence early embryo development. We studied human male and female germ cells and profi led their epigenetic repertoire. Further, we asked the question, is misregulation of that poising a common theme observed in infertility and aging in sperm? We pursued one part of this question in Chapter 2 where we investigated the changes in DNA methylation in sperm during the natural process of aging. We analyzed sperm from aged-matched donors and found that sperm on a global level gained DNA methylation over time, but notably, specifi c regions associated with genes linked to neuropsychiatric disorders signifi cantly lost DNA methylation in sperm from aged donors. This raised the intriguing question if the increase in observed neuropsychiatric disorders in offspring from older fathers could be linked to the loss of DNA methylation in sperm of specifi c genes also implicated in neuropsychiatric disorders. Further, we asked if abnormalities in chromatin are seen in sperm from infertile patients. We tested seven imprinted regions in oligozoospermic and abnormal protamine patients and found a correlation of DNA methylation abnormalities at the promoters of these genes in infertile sperm. Our fi ndings from this study are summarized in a publication detailed in Appendix A. Finally, we asked if changes in polyadenylation of transcripts in human oocytes could give us an insight into oocyte maturation and early human embryo development. We developed a novel bioinformatics tool called PANDA (Chapter 3) that enabled the analysis of relative polyA changes in transcripts between two different conditions. One of the advantages of this method is that it can utilize any iv RNA-seq dataset as long as it has not been biased for PolyA selection. Hence, we applied PANDA to the existing RNA-seq dataset, generated by our lab from human oocytes and early embryos, and investigated PolyA changes (Chapter 4). Strikingly, we were able to identify transcripts in humans that were previously reported to gain polyA in oocytes of drosophila and xenopus. We also identifi ed completely novel transcripts previously unknown to gain polyA during oocyte maturation. Hence, we are the fi rst group to identify these transcripts in human oocytes and embryos. Together we hope that by studying the epigenetic setup of germ cells we have gained more insight into understanding the regulation of programs critical in early embryo development.
Note on Constrained Cohomology
Creators: name: Delduc, Francois
name: Maggiore, Nicola
name: Piguet, Olivier
name: Wolf, Sylvain
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The cohomology of the BRS operator corresponding to a group of rigid symmetries is studied in a space of local field functionals subjected to a condition of gauge invariance. We propose a procedure based on a filtration operator counting the degree in the infinitesimal parameters of the rigid symmetry transformations. An application to Witten's topological Yang-Mills theory is given.
description: appendix and refs added
Revolutionize transportation management mindset with data-driven analytics
Creators: name: Chen, Zhuo
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Civil engineering
subject: FOS: Civil engineering
subject: Transportation

description: Data-driven analytics has been successfully utilized in many experience-oriented areas, such as education, business, and medicine. With the profusion of traffic-related data from Internet of Things and development of data mining techniques, data-driven analytics is becoming increasingly popular in the transportation industry. The objective of this research is to explore the application of data-driven analytics in transportation research to improve the traffic management and operations. Three problems in the respective areas of transportation planning, traffic operation, and maintenance management have been addressed in this research, including exploring the impact of dynamic ridesharing system in a multimodal network, quantifying non-recurrent congestion impact on freeway corridors, and developing infrastructure sampling method for efficient maintenance activities. First, the impact of dynamic ridesharing in a multimodal network is studied with agent-based modeling. The competing mechanism between dynamic ridesharing system and public transit is analyzed. The model simulates the interaction between travelers and the environment and emulates travelers' decision making process with the presence of competing modes. The model is applicable to networks with varying demographics. Second, a systematic approach is proposed to quantify Incident-Induced Delay on freeway corridors. There are two particular highlights in the study of non-recurrent congestion quantification: secondary incident identification and K-Nearest Neighbor pattern matching. The proposed methodology is easily transferable to any traffic operation system that has access to sensor data at a corridor level. Lastly, a high-dimensional clustering-based stratified sampling method is developed for infrastructure sampling. The stratification process consists of two components: current condition estimation and high-dimensional cluster analysis. High-dimensional cluster analysis employs Locality-Sensitive Hashing algorithm and spectral sampling. The proposed method is a potentially useful tool for agencies to effectively conduct infrastructure inspection and can be easily adopted for choosing samples containing multiple features. These three examples showcase the application of data-driven analytics in transportation research, which can potentially transform the traffic management mindset into a model of data-driven, sensing, and smart urban systems. The analytica
Finite BRST Mapping in Higher Derivative Models
Creators: name: Moshin, Pavel Yu.
name: Upadhyay, Sudhaker
name: Castro, Ricardo A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We continue the study of finite field dependent BRST (FFBRST) symmetry in the quantum theory of gauge fields. An expression for the Jacobian of path integral measure is presented, depending on a finite field-dependent parameter, and the FFBRST symmetry is then applied to a number of well-established quantum gauge theories in a form which includes higher-derivative terms. Specifically, we examine the corresponding versions of the Maxwell theory, non-Abelian vector field theory, and gravitation theory. We present a systematic mapping between different forms of gauge-fixing, including those with higher-derivative terms, for which these theories have better renormalization properties. In doing so, we also provide the independence of the S-matrix from a particular gauge-fixing with higher derivatives. Following this method, a higher-derivative quantum action can be constructed for any gauge theory in the FFBRST framework.
description: 9 pages, published in Braz. J. Phys