cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Toolkit voor de training van docenten
Creators: name: Scheuer, Claude
name: Heck, Sandra
Publisher: name: Zenodo
Year: 2020
Subjects: motor competence
children
teacher
promotion
assessment

description: In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training van docenten ontwikkeld met daarbij een bijbehorende gebruikershandleiding. Het doel van deze toolkit is voornamelijk om op het niveau van de reguliere lessen lichamelijke opvoeding aanpassingen te initiëren die van toepassing zijn op de inhoud en methoden in de lichamelijke opvoeding. De training voor docenten is opgedeeld in een praktisch en theoretisch deel. Allereerst worden leraren vertrouwd gemaakt met het MOBAK concept, de meting, testprocedure, de gegevensverwerking en evaluatie, evenals met de interpretatie van de testresultaten. In een tweede deel leren ze hoe ze van de diagnose van de basismotorische competenties van studenten en de sterke en zwakke punten die bij de beoordeling zijn geïdentificeerd, kunnen komen tot concrete interventies. Dit kan door het MOBAK kader en de bijbehorende hand-outs te gebruiken in de vorm van een modulaire ondersteunende toolkit. Deze toolkit kan ingezet worden in concrete onderwijssituaties om kinderen met aanvullende behoeften in basismotorische competenties te ondersteunen. Aangezien de training voor docenten de uitvoering van de toolkit voor de brede motorische ontwikkeling (Scheuer & Heck, 2020), gebaseerd op het MOBAK-concept en meting (Herrmann, 2018), wil ondersteunen en vergemakkelijken, wordt in dit document verwezen naar de ondersteunende toolkit en de MOBAK-testhandleiding.
description: Project "Basic Motor Competencies in Europe – Assessment and Promotion" (BMC-EU); Funder: European Commission - Erasmus+ Programme of the European Union; Programme: Erasmus+ Sport: Collaborative Partnerships - 2017; Reference: 590777-EPP-1-2017-1-DE-SPO-SCP; Timeline: January 2018 - December 2019; Project Sheet: https://ec.europa.eu/programmes/erasmus-plus/projects/eplus-project-details/#project/590777-EPP-1-2017-1-DE-SPO-SCP
Films of Graphene Nanomaterials Formed by Ultrasonic Spraying of Their Stable Suspensions
Creators: name: Modesto-López, Luis B.
name: Miettinen, Mirella
name: Riikonen, Joakim
name: Torvela, Tiina
name: Pfüller, Carsten
name: Vesa-Pekka Lehto
name: Lähde, Anna
name: Jokiniemi, Jorma
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Astronomy, Astrophysics, Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biophysics

description: Graphene, a two-dimensional carbon allotrope, exhibits excellent optoelectronic properties. The assembly of graphene into films provides a platform to deepen the study of its interaction with varying surfaces, to engineer devices, and to develop functional materials. A general approach to produce graphene films consists of preparing a dispersion and laying it on a substrate of choice, followed by solvent evaporation. Here we report the preparation of stable suspensions of new types of graphene nanomaterials namely, graphene nanoflowers (GNFs) and multi-layer graphene (MLG) flakes, in ethanol, N,N Dimethylformamide (DMF), and N-methyl-2-pyrrolidone (NMP). Sprayable suspensions of both GNFs and MLG were prepared in DMF/ethanol, which showed high stability, without addition of any surfactant. The stable suspensions were used to deposit MLG/GNF films on glass substrates. Calculations of the initial droplet size and of the timescale of droplet evaporation are performed and possible thermophoretic effects on droplet deposition discussed as well. Coating glass substrates with a methacrylic acid - methyl methacrylate (MA) copolymer prior to the deposition significantly improved the adhesion of the nanomaterials to the substrate. With the MA coating, a substrate coverage of nearly 100% was achieved at 14-min spraying time for 0.05 wt% GNF and 0.1 wt% MLG suspensions. Raman spectra of the GNF and MLG films reveal that the films were made of MLG in which the individual graphene layers rotated from each other as in turbostratic graphene. This work provides a general approach to prepare graphene nanomaterial suspensions and to create films for a variety of applications. The spraying process applied in the current work is highly scalable and allows control of film characteristics through process parameters.
No place like home? Explaining venue selection of regional offices in Brussels
Creators: name: Beyers, Jan
name: Donas, Tom
name: Fraussen, Bert
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology

description: ABSTRACTWhile subnational authorities strongly mobilize in Brussels, they do not lobby all EU-level venues to the same extent. This article explains the varying intensity with which regional offices interact with various EU-level policy-making venues when seeking to influence EU policies. Theoretically, we complement an exchange-based perspective with political-institutional and contextual factors, such as regional political autonomy and the degree of preference alignment with key policy-making venues. To test our hypotheses, we rely on evidence collected through 33 face-to-face interviews with regional representations concerning their lobbying activities in four salient policy processes. Our results highlight that while most offices regularly interact with both national and supranational venues, the central government representation in Brussels is always, irrespective of what is at stake, the most important contact point. Furthermore, we also find that policy alignments shape venue selection, indicating some evidence of strategic manoeuvring.
Films of Graphene Nanomaterials Formed by Ultrasonic Spraying of Their Stable Suspensions
Creators: name: Modesto-López, Luis B.
name: Miettinen, Mirella
name: Riikonen, Joakim
name: Torvela, Tiina
name: Pfüller, Carsten
name: Vesa-Pekka Lehto
name: Lähde, Anna
name: Jokiniemi, Jorma
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Astronomy, Astrophysics, Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biophysics

description: Graphene, a two-dimensional carbon allotrope, exhibits excellent optoelectronic properties. The assembly of graphene into films provides a platform to deepen the study of its interaction with varying surfaces, to engineer devices, and to develop functional materials. A general approach to produce graphene films consists of preparing a dispersion and laying it on a substrate of choice, followed by solvent evaporation. Here, we report the preparation of stable suspensions of new types of graphene nanomaterials namely, graphene nanoflowers (GNFs) and multi-layer graphene (MLG) flakes, in ethanol, N,N-dimethylformamide (DMF), and N-methyl-2-pyrrolidone (NMP). Sprayable suspensions of both GNFs and MLG were prepared in DMF/ethanol, which showed high stability, without addition of any surfactant. The stable suspensions were used to deposit micrometer-thick MLG/GNF films on glass substrates. Calculations of initial droplet size and of timescale of droplet evaporation are performed and possible thermophoretic effects on droplet deposition discussed as well. Coating glass substrates with a methacrylic acid–methyl methacrylate (MA) copolymer prior to the deposition significantly improved the adhesion of the nanomaterials to the substrate. With the MA coating, a substrate coverage of nearly 100% was achieved at 14-min spraying time for 0.05 wt% GNF and 0.1 wt% MLG suspensions. Raman spectra of the GNF and MLG films reveal that the films were made of MLG in which the individual graphene layers rotated from each other as in turbostratic graphene. This work provides a general approach to prepare graphene nanomaterial suspensions and to create films for a variety of applications. The spraying process applied in the current work is highly scalable and allows control of film characteristics through process parameters.Copyright 2015 American Association for Aerosol Research
The Benefits of Undergraduate Research: The Student’s Perspective
Creators: name: Madan, Christopher
name: Teitge, Braden
Publisher: name: figshare
Year: 2014
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: The undergraduate experience is greatly enriched by attaining research experience early and often. Recently this has been demonstrated empirically and discussed at length in a variety of disciplines, including but not limited to engineering (Narayanan, 1999), medicine (Murdoch-Eaton et al., 2010), biology (Reynolds, Smith, Moskovitz, & Sayle, 2009), physiology (Desai et al., 2008), neuroscience (Frantz, DeHaan, Demetrikopoulos, & Carruth, 2006), psychology (Wayment & Dickson, 2008), as well as in multidisciplinary discussions in prestigious journals (e.g., Carrero-Martinez, 2011; Russell, Hancock, & McCullough, 2007). However, while the benefits of undergraduate research are numerous and far-reaching, the majority of articles on the topic focus on a retrospective viewpoint of undergraduate research initiatives at specific universities. This paper looks forward, offering the students’ perspective on how academic advisers can advocate for undergraduate research and engage junior and senior undergraduates in research, as well as how advisers can promote undergraduate research within the faculty.
How can supercomputers help  modelling and next challenges of HPC?
Creators: name: Acosta, Mario
Publisher: name: Zenodo
Year: 2024

description: As part of the 2024 UN Ocean Decade Conference, TipESM co-organised the Satellite Event, Monitoring the Ocean, in Barcelona on April 8th, 2024. The event consisted of a panel discussion and exhibition event. As part of the panel discussion, we had 6 experts providing overviews on ocean monitoring from Earth Observations to in situ observations, to supercomputers and modelling. Mario Acosta presented work connected with the ESiWACE project and how supercomputers can help modelling and the next challenges of HPC.
Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients
Creators: name: Damme, Michaël Van
name: Emerence Crompot
name: Meuleman, Nathalie
name: Mineur, Philippe
name: Dessars, Barbara
name: Housni, Hakim El
name: Bron, Dominique
name: Lagneaux, Laurence
name: Stamatopoulos, Basile
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Hematology
Cancer
Meta Science
Molecular Biology
Cell Biology
Biochemistry

description: Histone deacetylases (HDAC) play a crucial role in transcriptional regulation and are often deregulated in many cancers. However, global HDAC enzymatic activity has never been investigated in Chronic Lymphocytic Leukemia (CLL). We measured HDAC activity in protein extracts from CD19+ B-cells purified from 114 CLL patients with a median follow-up of 91 months (range: 11–376). HDAC activity was equivalent in CLL and normal B-cells but higher in patients who died during the study than in living patients (152.1 vs. 65.04 pmol; P = 0.0060). Furthermore, HDAC activity correlated with treatment-free survival (TFS; P = 0.0156) and overall survival (OS; P < 0.0001): patients with low HDAC activity (n = 75) had a median TFS and OS of 101 and >376 months, respectively, whereas patients with high HDAC activity (n = 39) had a median TFS and OS of 47 and 137 months, respectively. Multivariate analyses indicated that HDAC activity is an independent predictor of OS (hazard ratio = 7.68; P = 0.0017). Finally, HDAC activity increased after B-cell receptor stimulation using IgM, suggesting a role for microenvironment stimuli (n = 10; P = 0.0371). In conclusion, high HDAC activity in CLL B-cells is associated with shorter TFS and OS and is an independent marker of OS, refining the use of other prognostic factors. This work provides a biological base for the use of HDAC inhibitors in CLL treatment.
A Hertfordshire Miscellany: A Broxbourne School for young ladies; Youngsbury in the Eighteenth century; A Foreign View of Hertfordshire in the Eighteenth Century; Arthur Young at North Mymms; The Misfortunes of John Barton, of Studham
Creators: name: Squires, EE
Publisher: name: Archaeology Data Service
Year: 2025

description: Transactions of the East Hertfordshire Archaeological Society, 8.1, 5-21
Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: A cohort study
Creators: name: Martín-Núñez, Gracia María
name: Elehazara Rubio-Martín
name: Cabrera-Mulero, Rebeca
name: Rojo-Martínez, Gemma
name: Olveira, Gabriel
name: Valdés, Sergio
name: Soriguer, Federico
name: Castaño, Luis
name: Morcillo, Sonsoles
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: In the last years, epigenetic processes have emerged as a promising area of complex diseases research. DNA methylation measured in Long Interspersed Nucleotide Element 1 (LINE-1) sequences has been considered a surrogate marker for global genome methylation. New findings have suggested the potential involvement of epigenetic mechanisms in Type 2 diabetes (T2DM) as a crucial interface between the effects of genetic predisposition and environmental influences. Our study evaluated whether global DNA methylation predicted increased risk from T2DM or other carbohydrate metabolism disorders in a cohort study. We used a prospective cohort intervention study and a control group. We collected phenotypic, anthropometric, biochemical, and nutritional information from all subjects. Global LINE-1 DNA methylation was quantified by pyrosequencing technology. Subjects that did not improve their carbohydrate metabolism status showed lower levels of global LINE-1 DNA methylation (63.9 ± 1.7 vs. 64.7 ± 2.4) and they practiced less intense physical activity (5.8% vs. 21.5%). Logistic regression analyses showed a significant association between LINE-1 DNA methylation and metabolic status after adjustment for sex, age, BMI, and physical activity. Our study showed that lower LINE-1 DNA methylation levels were associated with a higher risk metabolic status worsening, independent of other classic risk factors. This finding highlights the potential role for epigenetic biomarkers as predictors of T2DM risk or other related metabolic disorders.
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth
Creators: name: Lévesque, Mélissa L
name: Casey, Kevin F
name: Szyf, Moshe
name: Ismaylova, Elmira
name: Ly, Victoria
name: Marie-Pier Verner
name: Suderman, Matthew
name: Brendgen, Mara
name: Vitaro, Frank
name: Dionne, Ginette
name: Boivin, Michel
name: Tremblay, Richard E
name: Booij, Linda
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111714 Mental Health
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biophysics

description: DNA methylation patterns are characterized by highly conserved developmental programs, but allow for divergent gene expression resulting from stochastic epigenetic drift or divergent environments. Genome-wide methylation studies in monozygotic (MZ) twins are providing insight into the extent of epigenetic variation that occurs, irrespective of genotype. However, little is known about the variability of DNA methylation patterns in adolescence, a period involving significant and rapid physical, emotional, social, and neurodevelopmental change. Here, we assessed genome-wide DNA methylation using the 450 K Illumina BeadChip in a sample of 37 MZ twin pairs followed longitudinally since birth to investigate: 1) the extent of variation in DNA methylation in identical genetic backgrounds in adolescence and; 2) whether these variations are randomly distributed or enriched in particular functional pathways. We also assessed stability of DNA methylation over 3–6 months to distinguish stable trait-like and variable state-like genes. A pathway analysis found high within-pair variability in genes associated with development, cellular mechanisms, tissue and cell morphology, and various disorders. Test-retest analyses performed in a sub-sample of 8 twin pairs demonstrated enrichment in gene pathways involved in organismal development, cellular growth and proliferation, cell signaling, and particular disorders. The variability found in functional gene pathways may plausibly underlie phenotypic differences in this adolescent MZ twin sample. Furthermore, we assessed stability of methylation over 3–6 months and found that some genes were stable while others were unstable, suggesting that the methylome remains dynamic in adolescence and that dynamic sites tend to be organized in certain gene pathways.
Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients
Creators: name: Damme, Michaël Van
name: Emerence Crompot
name: Meuleman, Nathalie
name: Mineur, Philippe
name: Dessars, Barbara
name: Housni, Hakim El
name: Bron, Dominique
name: Lagneaux, Laurence
name: Stamatopoulos, Basile
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Hematology
Cancer
Meta Science
Molecular Biology
Cell Biology
Biochemistry

description: Histone deacetylases (HDAC) play a crucial role in transcriptional regulation and are often deregulated in many cancers. However, global HDAC enzymatic activity has never been investigated in Chronic Lymphocytic Leukemia (CLL). We measured HDAC activity in protein extracts from CD19+ B-cells purified from 114 CLL patients with a median follow-up of 91 months (range: 11–376). HDAC activity was equivalent in CLL and normal B-cells but higher in patients who died during the study than in living patients (152.1 vs. 65.04 pmol; P = 0.0060). Furthermore, HDAC activity correlated with treatment-free survival (TFS; P = 0.0156) and overall survival (OS; P < 0.0001): patients with low HDAC activity (n = 75) had a median TFS and OS of 101 and >376 months, respectively, whereas patients with high HDAC activity (n = 39) had a median TFS and OS of 47 and 137 months, respectively. Multivariate analyses indicated that HDAC activity is an independent predictor of OS (hazard ratio = 7.68; P = 0.0017). Finally, HDAC activity increased after B-cell receptor stimulation using IgM, suggesting a role for microenvironment stimuli (n = 10; P = 0.0371). In conclusion, high HDAC activity in CLL B-cells is associated with shorter TFS and OS and is an independent marker of OS, refining the use of other prognostic factors. This work provides a biological base for the use of HDAC inhibitors in CLL treatment.
Studies on development of the formulated feed for the grow-out phase of mud crabs, Scylla serrata (Forskal 1775) and S. paramamosain (Estampador 1949)
Creators: name: Vu, Tuan
Publisher: name: Charles Darwin University
Year: 2007

description: This thesis investigates some fundamental nutrient requirements for the development of a formulated feed for the grow-out phase of mud crabs, Scylla serrata (Forskal 1775) in Australia and S. paramamosain (Estampador 1949) in Vietnam. Apparent digestibility (AD) for dry matter, protein, and energy were found for 7 ingredients in the diet of S. serrata, including defatted soybean meal, fish meal, blood meal, shrimp meal, cod liver oil, wheat flour, and alpha cellulose. AD for dry matter, protein, lipid, ash, and nitrogen free extract were determined for 13 ingredients in the diet of S. paramamosain, namely defatted soybean meal, full fat soybean meal, cassava meal, wheat flour, rice bran, fish meal, acetes meal, peanut oil cake meal, coconut oil cake meal, Korean fish oil, Korean squid oil, local pig fat oil, and vegetable oil. Optimal requirements for digestible protein, total balanced essential amino acid, digestible energy, and two essential fatty acids, linoleic and linolenic acids, were determined. The optimal digestible protein requirement by juveniles of S. serrata was approximately 530 g kg-1 for maximum weight gain, and 460 g kg-1 for minimum feed conversion ratio. The optimal requirements of S. serrata for the total balanced essential amino acid and the digestible energy were 258 g kg-1 and 15.7 MJ kg-1, respectively. The optimal requirement of juveniles of S. paramamosain for linolenic acid and linoleic acid were 8.1 g kg-1 and 11.5 g kg-1, respectively. These results were used to formulate a feed that was superior to trash fish (Oreochromis mossambicus) in terms of survival rate and weight gain, but inferior to the more expensive commercial vital prawn feed in terms of growth and feed conversion ratio.
Data file 1
Creators: name: Dehdashti, Alireza
name: Kangarloo, Marzieh Belji
name: Fatemi, Farin
name: paknazar, Fateme
Publisher: name: figshare
Year: 2022
Subjects: subject: 111005 Mental Health Nursing
subject: FOS: Health sciences

description: Information on survey's data source, design, and methodoogy on occupational stressors and mental health among nurses are included.
Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: A cohort study
Creators: name: Martín-Núñez, Gracia María
name: Elehazara Rubio-Martín
name: Cabrera-Mulero, Rebeca
name: Rojo-Martínez, Gemma
name: Olveira, Gabriel
name: Valdés, Sergio
name: Soriguer, Federico
name: Castaño, Luis
name: Morcillo, Sonsoles
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: In the last years, epigenetic processes have emerged as a promising area of complex diseases research. DNA methylation measured in Long Interspersed Nucleotide Element 1 (LINE-1) sequences has been considered a surrogate marker for global genome methylation. New findings have suggested the potential involvement of epigenetic mechanisms in Type 2 diabetes (T2DM) as a crucial interface between the effects of genetic predisposition and environmental influences. Our study evaluated whether global DNA methylation predicted increased risk from T2DM or other carbohydrate metabolism disorders in a cohort study. We used a prospective cohort intervention study and a control group. We collected phenotypic, anthropometric, biochemical, and nutritional information from all subjects. Global LINE-1 DNA methylation was quantified by pyrosequencing technology. Subjects that did not improve their carbohydrate metabolism status showed lower levels of global LINE-1 DNA methylation (63.9 ± 1.7 vs. 64.7 ± 2.4) and they practiced less intense physical activity (5.8% vs. 21.5%). Logistic regression analyses showed a significant association between LINE-1 DNA methylation and metabolic status after adjustment for sex, age, BMI, and physical activity. Our study showed that lower LINE-1 DNA methylation levels were associated with a higher risk metabolic status worsening, independent of other classic risk factors. This finding highlights the potential role for epigenetic biomarkers as predictors of T2DM risk or other related metabolic disorders.
Accumulation of metals in cancerous and healthy tissues of patients with lung cancer in Southern Poland
Creators: name: Łukasz J. Binkowski
name: Paweł Rogoziński
name: Shubhadeep Roychoudhury
name: Bruliński, Krzysztof
name: Kucharzewski, Marek
name: Łaciak, Tomasz
name: Massanyi, Peter
name: Stawarz, Robert
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: Genetics
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Biochemistry

description: The aim of this study was to investigate whether the concentrations of metals differ among patients with and without lung cancer with different smoking status and living in industrialized environments. We also evaluated the relationships between metals and blood parameters including hematocrit level (Hct), hemoglobin concentration (Hb), red (RBC) and white (WBC) blood cells numbers. Concentrations of metals were measured with AAS (copper - Cu, iron - Fe, magnesium - Mg, zinc - Zn) and CV-AAS (mercury - Hg). Neither smoking status nor industrialization could be considered as a significant factor for metals accumulation in blood, lungs and tumor tissues, with the exception of mercury which differed in the aspect of industrialization. According to the type of the disease, Fe, Hg and Mg concentrations differed significantly in lungs. Correlations between metals and blood parameters were observed. Additionally, concentrations of Mg, Cu and Zn were correlated between lungs and tumor tissue of patients with cancer as well as they all were related to each other in lungs, tumor and blood tissues.
title: Ανάκτηση νερού από μονάδες υγρών αποβλήτων στα πλαίσια της κυκλικής οικονομίας: τιμολόγηση και εφαρμογές
title: Water recovery and reuse from waste water treatment plants. Pricing and applications
titleType: AlternativeTitle
Creators: name: Τσουλουχάς, Ιωάννης
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Επαναχρησιμοποίηση νερού
Ανάκτηση νερού
Μονάδες επεξεργασίας υγρών αποβλήτων
Εφαρμογές ανακτώμενου νερού
Τιμολόγηση ανακτώμενου νερού
Κανονισμοί επαναχρησιμοποίησης νερού
Κυκλική οικονομία
Υγρά απόβλητα

description: Η ανάκτηση και η επαναχρησιμοποίηση νερού από τις μονάδες επεξεργασίας υγρών αποβλήτων έχουν κερδίσει σημαντική προσοχή τα τελευταία χρόνια λόγω των αυξανόμενων ανησυχιών σχετικά με τη λειψυδρία και τη βιωσιμότητα. Η εργασία επιδιώκει μέσω της βιβλιογραφικής ανασκόπησης να μελετήσει τις κυρίαρχες τάσεις και στρατηγικές στην τιμολόγηση και εφαρμογές του ανακτημένου νερού από μονάδες ανάκτησης και επεξεργασίας υγρών αποβλήτων. Η εργασία ξεκινά με την ερεύνα του υποβάθρου της επαναχρησιμοποίησης νερού, γίνεται αναφορά στα ύδατα και τα υγρά απόβλητα καθώς και στην παρούσα κατάσταση των υδάτινων πόρων και της λειψυδρίας. Αναφέρεται η κυκλική οικονομία και ο ρόλος της στην επαναχρησιμοποίηση νερού, η σημασία που έχει η ανάκτηση του νερού στην κοινωνία και το περιβάλλον καθώς και τα είδη ανάκτησης πέρα από το νερό. Στη συνέχεια παρουσιάζονται οι μονάδες επεξεργασίας υγρών αποβλήτων και οι τεχνικές που χρησιμοποιούνται για τον επιτυχή καθαρισμό των λυμάτων. Αναφέρονται οι παράγοντες που επηρεάζουν την ανάκτηση νερού καθώς και η σύσταση και πήγες των υγρών αποβλήτων. Ακολουθώντας γίνεται αναφορά στις εφαρμογές του ανακτημένου νερού όπως η γεωργική άρδευση, βιομηχανική χρήση και άλλα. Και την κατάσταση που επικρατεί στο κόσμο σχετικά με τις εφαρμογές του ανακτημένου νερού. Έπειτα είναι η σειρά της τιμολόγησης να αναφερθεί και ερευνά τις μεθόδους τιμολόγησης και περιπτώσεις τιμολόγησης ανά το κόσμο. Ακολουθούν οι νομοθεσίες και τα κανονιστικά πλαίσια που διέπουν στην επαναχρησιμοποίηση του νερού. Αναφέρεται σε κανονισμούς κρατών και οργανισμών. Τέλος βάση της εργασίας βγαίνουν κάποια συμπεράσματα.
title: Το παρόν και το μέλλον του κράτους πρόνοιας προς τους πολίτες με προβλήματα αναπηρίας: H ίδρυση των κέντρων πιστοποίησης αναπηρίας και η εξέλιξη τους μέχρι σήμερα
title: The present and the future of welfare state towards citizens with disabilities. The establishment of authentication center of persons with disabilities and the progress through years
titleType: AlternativeTitle
Creators: name: Καμάτσου, Βασιλική
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Αναπηρία
e-ΕΦΚΑ
Κοινωνική πολιτική
Κέντρο Πιστοποίησης Αναπηρίας
Κοινωνικό κράτος

description: Η συγκεκριμένη διπλωματική εργασία πραγματεύεται ένα αρκετά ευαίσθητο κομμάτι της κοινωνίας μας, ανθρώπους με αναπηρία. Η ανθρώπινη διαφορετικότητα, η θέση των ανθρώπων με ειδικές ανάγκες –αναπηρία στο ευρύτερο κοινωνικό σύνολο, η κοινωνική πολιτική και το κράτος πρόνοιας, αλληλεγγύης σε αυτούς τους πολίτες με δικαιώματα όπως όλοι είναι ένα κεφάλαιο πού όχι μόνο έχει ευαισθητοποιήσει το Ελληνικό κράτος και έχει στραφεί προς μια κοινωνική πολιτική αλλά και πολιτική όλων των κρατών μελών της Ευρωπαϊκής Ένωσης. Στην παρούσα διπλωματική γίνεται αναφορά στις έννοιες αναπηρία, κοινωνική πολιτική, κράτος πρόνοιας και επιδομάτων, ιστορική αναδρομή και αντιμετώπιση των ατόμων με ειδικές ανάγκες από την αρχαιότητα έως στην σημερινή κοινωνία, τα Κέντρα πιστοποίησης Αναπηρίας και ο ρόλος τους, Ηλεκτρονική Διακυβέρνηση και η πορεία των Κέντρων πιστοποίησης αναπηρίας έτσι ώστε σήμερα να έχουμε μεταβεί σε μια νέα εποχή με την δημιουργία της Εθνικής Πύλης Αναπηρίας.
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth
Creators: name: Lévesque, Mélissa L
name: Casey, Kevin F
name: Szyf, Moshe
name: Ismaylova, Elmira
name: Ly, Victoria
name: Marie-Pier Verner
name: Suderman, Matthew
name: Brendgen, Mara
name: Vitaro, Frank
name: Dionne, Ginette
name: Boivin, Michel
name: Tremblay, Richard E
name: Booij, Linda
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111714 Mental Health
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biophysics

description: DNA methylation patterns are characterized by highly conserved developmental programs, but allow for divergent gene expression resulting from stochastic epigenetic drift or divergent environments. Genome-wide methylation studies in monozygotic (MZ) twins are providing insight into the extent of epigenetic variation that occurs, irrespective of genotype. However, little is known about the variability of DNA methylation patterns in adolescence, a period involving significant and rapid physical, emotional, social, and neurodevelopmental change. Here, we assessed genome-wide DNA methylation using the 450 K Illumina BeadChip in a sample of 37 MZ twin pairs followed longitudinally since birth to investigate: 1) the extent of variation in DNA methylation in identical genetic backgrounds in adolescence and; 2) whether these variations are randomly distributed or enriched in particular functional pathways. We also assessed stability of DNA methylation over 3–6 months to distinguish stable trait-like and variable state-like genes. A pathway analysis found high within-pair variability in genes associated with development, cellular mechanisms, tissue and cell morphology, and various disorders. Test-retest analyses performed in a sub-sample of 8 twin pairs demonstrated enrichment in gene pathways involved in organismal development, cellular growth and proliferation, cell signaling, and particular disorders. The variability found in functional gene pathways may plausibly underlie phenotypic differences in this adolescent MZ twin sample. Furthermore, we assessed stability of methylation over 3–6 months and found that some genes were stable while others were unstable, suggesting that the methylome remains dynamic in adolescence and that dynamic sites tend to be organized in certain gene pathways.
PRISMA checklist for Wine Consumer Studies: Current Status and Future Agendas
Creators: name: MALLYA, JYOTHI
name: Neelavar Kelkar, Vageesh
name: Payini, Valsaraj
name: Kamath V P, Vasanth
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 359999
subject: Other commerce, management, tourism and services not elsewhere classified

description: PRISMA Checklist for Wine Consumer Studies: Current Status and Future Agendas
title: Η αναγκαιότητα αναβάθμισης της πρωτοβάθμιας και δημόσιας υγείας στην Ελλάδα
title: The necessity of upgrading primary and public healthcare in Greece
titleType: AlternativeTitle
Creators: name: Γεωργάκη, Έλλη Άννα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Πρωτοβάθμια Φροντίδα Υγείας
Δημόσια υγεία
Συστήματα υγείας
Προαγωγή υγείας
Αγωγή υγείας
Κατ’ οίκον φροντίδα υγείας
Εθνική στρατηγική
Σπύρος Δοξιάδης

description: Η δημόσια υγεία και η πρωτοβάθμια φροντίδα υγείας αποτελούν δύο κρίσιμους πυλώνες στη διασφάλιση ενός υγιούς και ευημερούντος πληθυσμού. Η δημόσια υγεία είναι κρίσιμη για την ευημερία μιας κοινωνίας, καθώς προστατεύει τον πληθυσμό από ασθένειες και απειλές όπως οι επιδημίες. Η δημόσια υγεία έλαβε ιδιαίτερης προβολής κατά την περίοδο της πανδημίας του κορωνοϊού (COVID-19), όπου διαδραμάτισε σε παγκόσμιο επίπεδο ζωτικό ρόλο στην αντιμετώπιση της. Οι αρχές δημόσιας υγείας ανέλαβαν δράση για την ενημέρωση του κοινού σχετικά με την ασφάλεια, τις προληπτικές πρακτικές και τη σημασία της τήρησης των οδηγιών υγείας. Μέσω της δημόσιας υγείας προωθείται η οικονομική αποδοτικότητα, καθώς προλαμβάνονται ασθένειες, μειώνεται το κόστος της υγειονομικής περίθαλψης, μιας και η πρόληψη είναι συνήθως πιο οικονομική από τη θεραπεία και αυξάνεται η παραγωγικότητα του πληθυσμού. Ενώ παράλληλα ενθαρρύνεται η ψυχολογική, σωματική και κοινωνική ευημερία του πληθυσμού. Από την άλλη πλευρά η πρωτοβάθμια φροντίδα υγείας αποτελεί ακρογωνιαίο λίθο για το σύστημα υγείας πολλών χωρών. Η πρωτοβάθμια φροντίδα υγείας λειτουργεί ως πύλη εισόδου στο υγειονομικό σύστημα, καθοδηγώντας τους ασθενείς προς περαιτέρω εξετάσεις ή ειδικευμένες υπηρεσίες, όταν αυτό είναι απαραίτητο. Επίσης, επιδρά στη μείωση του φόρτου του δευτεροβάθμιου και τριτοβάθμιου συστήματος υγείας, αφού παρέχει πρόληψη και διαχείριση των βασικών υγειονομικών προβλημάτων. Επιπλέον, η πρωτοβάθμια φροντίδα υγείας επιδρά θετικά στην πρόληψη των ασθενειών και τη βελτίωση της δημόσιας υγείας, συμβάλλοντας έτσι στην ολική υγεία. Η εργασία πραγματοποιήθηκε με σκοπό την κατανόηση αυτών των δύο εννοιών, της πορείας τους στο χρόνο, τη σύγκρισης τους με άλλες χώρες και την μελέτη των τελευταίων εθνικών στρατηγικών δημόσιας υγείας.
MgBr2 · OEt2: A Lewis Acid Catalyst for the O- and N-Boc Protection of Phenols and Amines
Creators: name: Schechter, Aaron
name: Goldrich, David
name: Chapman, Jessica R.
name: Uberheide, Beatrix M.
name: Lim, Daniel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Molecular Biology
Biochemistry
Biophysics

description: MgBr2 · OEt2 efficiently catalyzes the O- and N-tert-butoxycarbonylation of functionalized phenols and amines. The presented procedure is operationally simple and done under solvent-free conditions.
Cinnamic Acid and Caffeic Acid Effects on Gastric Tight Junction Proteins Analyzed in Xenopus laevis Oocytes
Creators: name: Vollstädt, Marie-Luise
name: Stein, Laura
name: Brunner, Nora
name: Amasheh, Salah
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: claudins
subject: epithelial barrier
subject: Xenopus oocytes
subject: tight junction
subject: cinnamic acid
subject: caffeic acid
subject: heterologous expression
subject: stomach
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Analysis of secondary plant compounds for the development of novel therapies is a common focus of experimental biomedicine. Currently, multiple health-supporting properties of plant-derived molecules are known but still information on many mechanisms is scarce. Cinnamic acid and caffeic acid are two of the most abundant polyphenols in human dietary fruits and vegetables. In this study, we investigated cinnamic acid and caffeic acid effects on the gastric barrier, which is primarily provided by members of the transmembrane tight junction protein family of claudins. The Xenopus laevis oocyte has been established, in recent years, as a heterologous expression system for analysis of transmembrane tight junction protein interactions, by performing paired oocyte experiments to identify an effect on protein–protein interactions, in vitro. In our current study, human gastric claudin-4, -5, and -18.2. were expressed and detected in the oocyte plasma membrane by freeze fracture electron microscopy and immunoblotting. Oocytes were paired and incubated with 100 µM or 200 µM cinnamic acid or caffeic acid, or Ringer’s solution, respectively. Caffeic acid showed no effect on the contact area strength of paired oocytes but led to an increased contact area size. In contrast, cinnamic acid-incubated paired oocytes revealed a reduced contact area and a strengthening effect on the contact area was identified. These results may indicate that caffeic acid and cinnamic acid both show an effect on gastric barrier integrity via direct effects on tight junction proteins.
Sample Preparation Techniques for Growth-Promoting Agents in Various Mammalian Specimen Preceding MS-Analytics
Creators: name: Klöppner, Laura
name: Harps, Lukas Corbinian
name: Parr, Maria Kristina
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: beta-2 agonists
subject: steroids
subject: solid phase extraction
subject: QuEChERs
subject: liquid–liquid extraction
subject: LC-MS
subject: GC-MS
subject: animals in sports
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: The misuse of growth-promoting drugs such as beta-2 agonists and steroids is a known problem in farming and sports competitions. Prior to the analysis of biological samples via liquid chromatography (LC)–mass spectrometry (MS) or gas chromatography (GC)–MS, sufficient sample preparation is required to reliably identify or determine the residues of drugs. In practice, broad screening methods are often used to save time and analyze as many compounds as possible. This review was conceptualized to analyze the literature from 2018 until October 2023 for sample preparation procedures applied to animal specimens before LC- or GC-MS analysis. The animals were either used in farming or sports. In the present review, solid phase extraction (SPE) was observed as the dominant sample clean-up technique for beta-2 agonists and steroids, followed by protein precipitation. For the extraction of beta-2 agonists, mixed-mode cation exchanger-based SPE phases were preferably applied, while for the steroids, various types of SPE materials were reported. Furthermore, dispersive SPE-based QuEChERs were utilized. Combinatory use of SPE and liquid–liquid extraction (LLE) was observed to cover further drug classes in addition to beta-2 agonists in broader screening methods.
Macrolide resistance in Mannheimia haemolytica isolates associated with bovine respiratory disease from the German national resistance monitoring program GERM-Vet 2009 to 2020
Creators: name: Kostova, Valeria
name: Hanke, Dennis
name: Kaspar, Heike
name: Fiedler, Stefan
name: Schwarz, Stefan
name: Krüger-Haker, Henrike
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Pasteurellaceae
subject: antimicrobial resistance (AMR)
subject: integrative and conjugative element (ICE)
subject: whole-genome sequencing (WGS)
subject: cattle
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Data collected from the German national resistance monitoring program GERM-Vet showed slowly increasing prevalence of macrolide resistance among bovine respiratory disease (BRD)-associated Pasteurellacae from cattle over the last decade. The focus of this study was to analyze the genetic basis of antimicrobial resistance (AMR) and the prevalence of multidrug-resistance (MDR)-mediating integrative and conjugative elements (ICEs) in 13 German BRD-associated Mannheimia haemolytica isolates collected between 2009 and 2020 via whole-genome sequencing. Antimicrobial susceptibility testing (AST) was performed via broth microdilution according to the recommendations of the Clinical and Laboratory Standards Institute for the macrolides erythromycin, tilmicosin, tulathromycin, gamithromycin, tildipirosin, and tylosin as well as 25 other antimicrobial agents. All isolates either had elevated MICs or were resistant to at least one of the macrolides tested. Analysis of whole-genome sequences obtained by hybrid assembly of Illumina MiSeq and Oxford Nanopore MinION reads revealed the presence of seven novel Tn7406-like ICEs, designated Tn7694, and Tn7724- Tn7729. These ICEs harbored the antimicrobial resistance genes erm(T), mef (C), mph(G), floR, catA3, aad(3“)(9), aph(3‘)-Ia, aac(3)-IIa, strA, strB, tet(Y), and sul2 in different combinations. In addition, mutational changes conferring resistance to macrolides, nalidixic acid or streptomycin, respectively, were detected among the M. haemolytica isolates. In addition, four isolates carried a 4,613-bp plasmid with the β-lactamase gene blaROB − 1. The detection of the macrolide resistance genes erm(T), mef (C), and mph(G) together with other resistance genes on MDR-mediating ICEs in bovine M. haemolytica may explain the occurrence of therapeutic failure when treating BRD with regularly used antimicrobial agents, such as phenicols, penicillins, tetracyclines, or macrolides. Finally, pathogen identification and subsequent AST is essential to ensure the efficacy of the antimicrobial agents applied to control BRD in cattle.
Domino Reaction for the Synthesis of Highly Functionalized Triazatricyclo[6.2.2.01,6]dodecane
Creators: name: Gunasekar Ramachandran
name: Kulathu Iyer Sathiyanarayanan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Molecular Biology
subject: Biochemistry
subject: Biophysics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry

description: A simple and highly efficient protocol has been developed for the synthesis of triazatricyclo[6.2.2.01,6]dodecane-9,12-dione (TATCD) derivatives. Use of metal hydroxide catalyst in the presence of protic solvent plays a key role in these reaction transformations. Mechanistic studies specify that the proposed mechanism proceeds only via aldol reaction, condensation, cyclization, and dehydration to form the desired product. This current protocol provides several advantages such as use of a readily available precursor, consumption of less energy, short reaction time, moderate to good yields, and convenient workup.
How to identify weather patterns associated with occurrences of extreme events in models (D1.1)
Creators: name: Ruggieri, Paolo
Publisher: name: Zenodo
Year: 2019

description: Meridional transport of heat by transient atmospheric eddies is a key component of the energy budget of the Arctic and high latitude regions. While transport in the mid-latitudes is known to be modulated by large-scale low frequency flow regimes, little is known about the link between heat flux in the polar cap and mid-latitude circulation regimes. Recent studies suggest that heat and moisture transport into polar regions happens in bursts that are associated with propagation of storms and atmospheric blocking. While the picture is evolving, a systematic assessment is still lacking. We investigate the modulation of transient, poleward atmospheric eddy heat flux induced by the variability of the atmospheric circulation in the North Atlantic sector. Heat transport is defined by meridional advection of moist static energy, and the circulation anomalies are diagnosed with a widely used clustering technique, a jet latitude index and a blocking index. The analysis is carried out for the extra tropics in the Northern Hemisphere but special emphasis is given to heat transport crossing the 70 ◦N latitude circle. Results are based on an atmospheric reanalysis for a total of 38 extended cold seasons. Establishing quantitative relationships between circulation regimes and poleward heat transport by transient eddies can help understand linkages between mid-latitudes and the Arctic, and evaluate how they are represented in coupled GCMs. In principle, it can help exploit predictability on a sub- seasonal time scale. The relationship between extreme events of strong heat flux and circulation regimes is also assessed and the analysis indicates a fundamental role of blocking in the North Atlantic sector. The presented empirical relationship between heat flux variability and extreme events can serve as a powerful tool for predictability analysis, but also for the evaluation of model variability.
description: The Blue-Action project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No 727852
Graphene Oxide as Recyclable Catalyst for One-Pot Synthesis of α-Aminophosphonates
Creators: name: Dhopte, Kiran B.
name: Dnyaneshwar S. Raut
name: Patwardhan, Anand V.
name: Parag R. Nemade
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Physiology
subject: Biochemistry
subject: Science Policy
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology

description: We report the synthesis of α-aminophosphonates from aromatic aldehydes, aromatic and aliphatic amines, and trimethylphosphite (Kabachnik–Fields reaction) using a “carbocatalyst,” graphene oxide, at room temperature with excellent yield and recyclability. Enhanced catalytic activity of graphene oxide as compared to other catalysts studied is possibly due to the presence of carboxylic acid and hydroxyl groups.
MgBr2 OEt2 – A Lewis Acid Catalyst for the O- and N-Boc Protection of Phenols and Amines
Creators: name: Schechter, Aaron
name: Goldrich, David
name: Chapman, Jessica R.
name: Uberheide, Beatrix M.
name: Lim, Daniel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Molecular Biology
Biochemistry
Biophysics

description: MgBr2 OEt2 efficiently catalyzes the O- and N-tert-butoxycarbonylation of functionalized phenols and amines. The presented procedure is operationally simple and done under solvent free conditions.