title: ÐÐ¾Ð»ÑÑÐµÐ½Ð¸Ðµ Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ² ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ñ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ ÑÑÑÐµÐºÑÐ¾Ð¼ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ñ Ð¸ÑÐ¾Ð·Ð°Ð½Ð° Ð¸ Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» Ñ Ð¸ÑÐ¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Obtaining and investigation of composite materials with hemostatic effect based on chitosan and chitin nanofibrils
Creators: name: ÐÐ°ÐµÐ²ÑÐºÐ°Ñ, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ñ Ð¸ÑÐ¾Ð·Ð°Ð½
Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð»Ñ Ñ Ð¸ÑÐ¸Ð½Ð°
Ð¼Ð¾ÐºÑÑÐ¹ Ð¼ÐµÑÐ¾Ð´ ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ñ
Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»
Ð¾ÑÑÐ°Ð½Ð¾Ð²ÐºÐ° ÐºÑÐ¾Ð²Ð¾ÑÐµÑÐµÐ½Ð¸Ñ
ÑÐ¸Ð·Ð¸ÐºÐ¾-Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°
ÐºÐ¾Ð½ÑÐ°ÐºÑ Ñ ÐºÑÐ¾Ð²ÑÑ
chitosan
chitin nanofibrils
wet spinning method
hemostatic material
bleeding stop
physical and mechanical properties
contact with blood

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ¸ÑÐ¾Ð·Ð°Ð½Ð° Ð¸ Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» ÑÐ¸ÑÐ¸Ð½Ð° Ñ ÑÐµÐ»ÑÑ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÐºÑÐ¾Ð²ÐµÐ¾ÑÑÐ°Ð½Ð°Ð²Ð»Ð¸Ð²Ð°ÑÑÐµÐ³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð½Ð° Ð¸Ñ Ð¾ÑÐ½Ð¾Ð²Ðµ. ÐÐµÑÐ¾Ð´Ð¾Ð¼ Ð¼Ð¾ÐºÑÐ¾Ð³Ð¾ ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð²Ð¾Ð»Ð¾ÐºÐ½Ð° Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» ÑÐ¸ÑÐ¸Ð½Ð°, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ñ Ð¸Ñ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ ÑÐ¾ÑÐ±ÑÐ¸Ð¾Ð½Ð½ÑÑ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ» Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÑÐ½ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐ¹ Ð´Ð¸Ð°Ð¿Ð°Ð·Ð¾Ð½ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¹ Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» ÑÐ¸ÑÐ¸Ð½Ð° Ñ ÑÐ¾ÑÐºÐ¸ Ð·ÑÐµÐ½Ð¸Ñ ÑÐ¸Ð·Ð¸ÐºÐ¾-Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ². ÐÐ»Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ñ ÐºÑÐ¾Ð²ÑÑ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÑ in vitro. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÐºÐ¾Ð½ÑÐ°ÐºÑÐ° ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ñ ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐ¼Ð¸ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ°Ð¼Ð¸ ÐºÑÐ¾Ð²Ð¸ Ð¸ ÑÑÐµÐ¿ÐµÐ½Ñ Ð³ÐµÐ¼Ð¾Ð»Ð¸Ð·Ð° Ð¿Ð»Ð°Ð·Ð¼Ñ, ÐºÐ°Ðº Ð¸ Ð²Ð¿Ð¸ÑÑÐ²Ð°ÐµÐ¼Ð¾ÑÑÑ ÐºÑÐ¾Ð²Ð¸ Ð³ÑÐ±ÐºÐ°Ð¼Ð¸, Ð´Ð°Ð»Ð¸ Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð»Ð°Ð³Ð°ÑÑ, ÑÑÐ¾ Ð½Ð°Ð¸Ð±Ð¾Ð»ÑÑÐ¸Ð¼ ÐºÑÐ¾Ð²ÐµÐ¾ÑÑÐ°Ð½Ð°Ð²Ð»Ð¸Ð²Ð°ÑÑÐ¸Ð¼ ÑÑÑÐµÐºÑÐ¾Ð¼ Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ 0,5% Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» ÑÐ¸ÑÐ¸Ð½Ð°. ÐÑÐ¿ÑÑÐ°Ð½Ð¸Ñ in vivo Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ´Ð¸Ð»Ð¸ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¿ÑÐ¾ÑÐ²Ð»ÐµÐ½Ð½Ð¾Ðµ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ Ð½Ð°Ð½Ð¾ÑÐ¸Ð±ÑÐ¸Ð»Ð» ÑÐ¸ÑÐ¸Ð½Ð° 0,5%. ÐÐ»Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÑÑÐµÐºÑÐ¾Ð² Ð´Ð¾Ð»Ð³Ð¾ÑÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð¼ Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¸Ñ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» Ð¿Ð¾Ð»ÑÑÐµÐ½ ÐºÑÐ¾Ð²ÐµÐ¾ÑÑÐ°Ð½Ð°Ð²Ð»Ð¸Ð²Ð°ÑÑÐ¸Ð¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð», ÑÑÐ°Ð²Ð½Ð¸Ð¼ÑÐ¹ Ð¿Ð¾ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ð¼Ð¸ ÐºÐ¾Ð¼Ð¼ÐµÑÑÐµÑÐºÐ¸Ð¼Ð¸ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°Ð¼Ð¸, Ð¸Ð·ÑÑÐµÐ½Ñ ÐµÐ³Ð¾ ÑÐ¸Ð·Ð¸ÐºÐ¾-Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÐ²Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð¼.
description: The given work is devoted to the study of the properties of composite materials based on chitosan and chitin nanofibrils to create a hemostatic agent. Composite fibers with different content of chitin nanofibrils were obtained by wet spinning method and their mechanical and sorption characteristics were investigated. As a result, the optimal range of concentrations of chitin nanofibrils was determined in terms of physical and mechanical properties. In vitro experiments were conducted to study the interaction of the obtained materials with blood. The results of the contact of composite fibers with blood cell elements and the degree of plasma hemolysis, as well as the absorption of blood by sponges, suggest the best hemostatic action of materials with 0,5% chitin nanofibrils content. In vivo tests confirmed the highest hemostatic effect of materials with the addition of 0,5% chitin nanofibrils. To study the effects of long-term interaction of composite materials with the body, their implantation was conducted. Thus, as a result of this work, a hemostatic material was obtained with comparable efficiency with existing commercial hemostatic drugs, its physical and mechanical characteristics were studied, as well as the consequences of interaction with the organism.