cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-docx-3-hpi-10.1177_15248399211028150 – Supplemental material for Money Matters: A Three-Step Process for Using Budget Data in Program Evaluation to Assess the Design and Management of a Novel Public Health Program
Creators: name: Uhd, Justin
name: DeGroff, Amy
name: Sharma, Krishna
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-3-hpi-10.1177_15248399211028150 for Money Matters: A Three-Step Process for Using Budget Data in Program Evaluation to Assess the Design and Management of a Novel Public Health Program by Justin Uhd, Amy DeGroff and Krishna Sharma in Health Promotion Practice
CHARACTERIZATION OF THE BINDING SITE OF STE24 DURING THE -AAXING CLEAVAGE
Creators: name: Germain, Chelsea C St.
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Medical biochemistry - proteins and peptides (incl. medical proteomics)
Biochemistry and cell biology not elsewhere classified

description: ZMPSTE24 is a seven transmembrane domain zinc metalloprotease that resides in the ER and inner nuclear membranes of mammalian cells. The crystal structures of both the mammalian and yeast homologs, ZMPSTE24 and Ste24, respectively, were solved recently and revealed a common novel structure. Both structures contain a large chamber of mixed hydrophobicity that is capped on both sides. The canonical catalytic HExxH zinc-binding motif lies inside the chamber. Defects in the enzymatic function of human ZMPSTE24 have been shown to cause premature aging disorders. In addition to the well-defined role ZMPSTE24 and Ste24 play in the maturation of prelamin A in mammals and a-factor in yeast, both proteins have been proposed to play protective roles in Type 2 diabetes and viral infections by interactions with the cellular translocon. ZMPSTE24 can also be inhibited by several common HIV aspartyl protease inhibitors, possibly causing the frequent and common side-effects of these prescribed drugs. As of now, no precise location for substrate binding has been identified in either ZMPSTE24 or Ste24. Thus, the goal of this project is to localize residues in the enzyme that are important for substrate binding. The yeast homolog Ste24 was used as a model system as it functionally complements the mammalian enzyme and can be reliably cloned, overexpressed, and purified in an active form. Three approaches were taken to directly determine the KD values for substrates of Ste24. The ability to perform a direct analysis of KD values of Ste24 mutations was successfully optimized using microscale thermophoresis. Through KD analysis, the Ste24 mutation G255A, while completely inactive, does not prevent substrate binding. Alternatively, L441A and L410A mutations showed both an increase in thermal stability and a decrease in binding affinity, that could explain their lower activity levels. A photoaffinity labeling-based proteomics experiment was utilized to precisely locate the site of the prenyl group to a hydrophobic patch lying just under a side portal of Ste24, near K234, during the -aaXing cleavage of a-factor maturation. To assess the method of inhibition of HIV protease inhibitors on Ste24 the conserved aspartate mutants were explored. All mutations of these aspartate residues resulted in a severe loss of Ste24 function and instability of the protein.
sj-docx-1-hpq-10.1177_13591053211037737 – Supplemental material for Multifactorial causal beliefs and colorectal cancer screening: A structural equation modeling investigation
Creators: name: Allen, Caitlin
name: Waters, Erika A
name: Hamilton, Jada G
name: Vu, Milkie
name: Gabriel, Jazmine
name: Roberts, Megan C
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: sj-docx-1-hpq-10.1177_13591053211037737 for Multifactorial causal beliefs and colorectal cancer screening: A structural equation modeling investigation by Caitlin Allen, Erika A Waters, Jada G Hamilton, Milkie Vu, Jazmine Gabriel and Megan C Roberts in Journal of Health Psychology
Forecasting of Solar Irradiance and Ambient Temperature of Site-Specific PV Applications Using Offsite Deep Neural Networks
Creators: name: Vergara, Jose Miguel Ramirez
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Electrical energy generation (incl. renewables, excl. photovoltaics)
Energy generation, conversion and storage (excl. chemical and electrical)
Knowledge representation and reasoning

description: The growing trend of solar photovoltaic (PV) adoption motivated homeowners and independent solar PV plants to assume the role of electricity generators. Utility companies need to address the changes in supply and demand to formulate effective distribution plans. Monitoring the power output of the photovoltaic array is a key task in ensuring the correct estimation of the electricity production of the system. Nevertheless, the literature recognizes the obstacle that expensive onsite monitoring sensors have on small-scale and medium-scale PV applications. Mathematical models based on the estimation of power output from historical data are the most used techniques to address the need for expensive monitoring systems. Estimating the power output of a PV array depends on the cell temperature, ambient temperature, and solar irradiance. The present thesis proposes a machine learning model to forecast site-specific ambient temperature and solar irradiance. The results contribute to the generation of low-cost data-driven models to save money by replacing the installation of on-site sensors. The methodology employed off-site publicly available weather data from neighboring weather stations as an alternative to on-site measurements. A 5-layer Deep Neural Network was trained using 5 years’ worth of historical data from a remote weather station in Green Bay, WI, to predict on-site parameters for a solar array located about 45 miles away in Keshena, WI. The model was suitable for site-specific ambient temperature prediction. The Ozone Dobson was a key parameter for solar irradiance prediction, but the proposed model was limited by the amount of available data.
Additional file 1 of Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial
Creators: name: Jia, Haiyan
name: Mai, Jiajia
name: Wu, Min
name: Chen, Hong
name: Li, Xiaojiao
name: Li, Cuiyun
name: Liu, Jingrui
name: Liu, Chengjiao
name: Hu, Yue
name: Zhu, Xiaoxue
name: Jiang, Xiuhong
name: Hua, Bo
name: Xia, Tian
name: Liu, Gang
name: Deng, Aiyun
name: Liang, Bo
name: Guo, Ruoling
name: Lu, Hui
name: Wang, Zhe
name: Chen, Huanming
name: Zhang, Zhijun
name: Zhang, Hong
name: Niu, Junqi
name: Ding, Yanhua
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1.
The institutional design of agri-environmental contracts - How stakeholder attitudes can inform policy making
Creators: name: Schulze, Christoph
name: Matzdorf, Bettina
Publisher: name: Oxford : Oxford University Press
Year: 2023
Subjects: subject: Agri-environmental schemes
subject: Environmental governance
subject: Institutional economics
subject: Policy design
subject: Social perspectives
subject: Stakeholder engagement
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft::333 | Boden- und Energiewirtschaft::333,7 | Natürliche Ressourcen, Energie und Umwelt

description: Agri-environmental climate measures (AECM) are considered a promising tool to achieve environmental policy goals. Not only farmers but also policy administrators and intermediaries are important actors whose attitudes and actions drive the success of these measures. To follow the idea of better stakeholder participation in the design of policy instruments, we analyse stakeholder viewpoints on the contract design of the AECM. We apply the Q methodology to 25 individuals from Brandenburg, Germany, who are from the farmer, policy administrator, and intermediary domains. We identify three distinct attitudinal profiles: the 'planners', the 'cooperators', and the 'individualists', which do not correspond to the three individual stakeholder groups. The results provide evidence that general differences in the viewpoints of policy designers and implementers on the one hand and farmers on the other hand are not a source of potential institutional mismatch. We further use the attitudinal profiles to develop three types of policy programmes with slightly different underlying rationalities. Policymakers could use such an approach to better develop target group-specific (sub)programmes in parallel. Our research strengthens the argument that multiple stakeholders should be involved in co-designing conservation measures. Moreover, behavioural factors should be considered in policy making processes.
Supplemental Material, sj-pdf-1-ppo-10.1177_07439156211014900 - Do Consumers Order More Calories in a Meal with a Diet or Regular Soft Drink? An Empirical Investigation Using Large-Scale Field Data
Creators: name: Ghotbi, Sina
name: Dhar, Tirtha
name: Weinberg, Charles B.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, sj-pdf-1-ppo-10.1177_07439156211014900 for Do Consumers Order More Calories in a Meal with a Diet or Regular Soft Drink? An Empirical Investigation Using Large-Scale Field Data by Sina Ghotbi, Tirtha Dhar and Charles B. Weinberg in Journal of Public Policy & Marketing
Pneumatic-based methods for force sensing and contact detection in telemanipulation tasks
Creators: name: GAUDENI, CHIARA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Teleoperation frameworks require a rich flow of information from the slave to the master side to be effective. While visual information is usually provided in any master-slave system, haptic perception is often missing. Despite the importance of the sense of touch while performing surgical procedures, minimally invasive robotic surgery still lacks the reproduction of haptic stimuli at the master side, mostly due to the difficulties in measuring forces at the contact site. However, there could be also procedures in open surgery in which a reduction of the natural haptic perception may occur, for example because vibrations generated by the surgical tool affect the surgeon?s perception.
This thesis addresses the challenge of measuring forces between surgical instruments and patient?s tissues both in robotic and open surgery, presenting innovative pneumatic force sensors that rely on pressure variations inside one or more chambers. Performance comparisons with accurate commercial force sensors proved the feasibility and effectiveness of the proposed approaches. Besides, many advantages can be appreciated in terms of size, cost, biocompatibility, possibility of changing sensor features such as stiffness according to the application, and absence of electronic components into the patient?s body.
The achieved results paved the way towards the exploitation of novel pneumatic-based devices for contact detection in more general robotic manipulation scenarios. In this context, a pneumatic device has been proposed to create soft inclusions in the environment that can be used by rigid grippers to achieve safer grasps. The use of soft sensing modules allows us to detect the contact between the gripper and the environment during grasp approach, and to estimate the approximate location and weight distribution of the object to be grasped. A system that combines the precision of rigid grippers with the adaptability of pneumatic-based devices was developed and successfully tested in grasping tasks with several different objects, taking advantage of the strengths of both rigid and soft robotics approaches.
Factors Impacting the Anticipated Pleasure of Potential Physical Activity Experiences
Creators: name: Kurth, Jordan
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Sport and exercise psychology

description: The regular performance of physical activity (PA) is associated with global health benefits, both physical and mental. However, most adults are not physically active. Furthermore, among the adults that do become physically active, most do not maintain this activity level over time. Increasing the pleasure associated with an activity increases the likelihood of maintaining that activity long-term. One possible way to make physical activities more pleasant is to create programs or activities based on characteristics that participants anticipate being most pleasurable instead of characteristics that bring the most health benefit.
To date, manipulating PA intensity is known to significantly affect the pleasure of being physically active. However, the effect of other PA characteristics on pleasure remains uninvestigated. The overall purpose of this dissertation is to develop a better understanding of the factors that are believed to impact the anticipated pleasure of potential PA experiences.
Specifically, this dissertation aims to: (1) provide a comprehensive literature review of previous pleasure-related PA research, including a review of the methodology used in the current study (conjoint analysis and audience segmentation), and (2) present an empirical investigation into the relative impact of selected characteristics (activity intensity, physical context, and social context) on the anticipated pleasure of potential PA experiences and how the impact differs by audience segment based on PA involvement. The findings from this study will provide a basis from which experimental manipulations of PA characteristics may be tested in order to maximize pleasure associated with PA, and how these manipulations can be customized for individuals that vary in terms of their level of PA involvement.
HBM4EU Harmonized Codebook Adults - Aligned studies
Creators: name: Govarts, Eva
name: Rodriguez Martin, Laura
name: Gilles, Liese
name: Remy, Sylvie
Publisher: name: Zenodo
Year: 2022
Subjects: codebook
aligned studies

description: HBM4EU Aligned studies harmonized codebooks. 3 codebooks are available, 1 for the HBM4EU aligned studies in children (6-11 years), 1 for the HBM4EU aligned studies in teenagers (12-19 years) and 1 for HBM4EU aligned studies in adults (20-39 years). More information about the HBM4EU aligned studies in Gilles et al 2021 (DOI: 10.1016/j.ijheh.2021.113809) and Gilles et al 2022 (Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants). The codebook includes a description of the variables and the coding format. Please note that the HBM4EU aligned studies have gone through a post-harmonization process.
description: This document has been created within the HBM4EU project. HBM4EU has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 733032.
STEREOSELECTIVE PERCUTANEOUS ABSORPTION AND TRANSDERMAL DELIVERY OF CHIRAL DRUGS
Creators: name: ALBERTI, ELISABETTA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: The selection of the enantiomeric or racemate form of a drug is a critical issue in the development of transdermal dosage forms. Indeed, the stratum corneum, the rate-limiting barrier to percutaneous absorption, is mainly composed by keratin and ceramides, which could potentially provide a chiral environment. Therefore, the different binding of enantiomers to keratin or the interactions with ceramides may give rise to differences in the permeation profiles of the enantiomers of chiral molecules.
Whereas the implication of different physicochemical properties between enantiomers and racemate in the in vitro skin permeation profiles have been studied, other aspects such as the effect of different counter-ions of ionisable chiral drug and different enantiomer of chiral permeation enhancers on skin permeability have not yet been extensively investigated.
This work was therefore focused on these two topics to deep actual understanding and to obtain information useful to rationalize the development of transdermal patches.
Among the chiral drugs, propranolol (PR) and ibuprofen (IB) were selected.
PR is a good candidate as its biological activity is largely associated to a single enantiomer. In humans, S-PR is about 100 times more potent than the R-enantiomer as ?-blocker and the information reported in literature about the in vitro skin permeability suggest that it can be a suitable candidate to transdermal delivery.
In the case of IB, largely used in the treatment of musculoskeletal injuries, only the S-enantiomer (S-IB) is therapeutically active, and extensive unidirectional chiral enantiomeric inversion of R to S occurs in vivo. Studies indicates that there aren?t any evidences for the metabolic inversion after topical administration. Till now, although the biological activity of IB resides with the S-enantiomer, the topical preparations available on the market contain the racemate.
This work aimed to determinate the skin permeability profiles of the selected drugs and in some case of the their salts, in order to evaluate the enantio-selectivity in the diffusion process. The salts were obtained salifing the drug, either as racemate and pure enantiomer, with different counter-ions, selected on the bases of their physico-chemical characteristics.
The experiments were performed by the modified Franz cell method, using human skin epidermis as a membrane and selecting the donor phase on the bases of the drug solubility. Suitable analytical methods for the quantitative determination of the drugs were developed. As a first step the skin permeability test was conducted by using saturated or diluted solutions.
On the bases of the preliminary permeability data, the formulation study of monolayer transdermal patches containing the drug in its most appropriate form , and, if necessary, the suitable promotion enhancer, was carried out.
sj-pdf-1-pus-10.1177_09636625211047974 – Supplemental material for The role of motivated science reception and numeracy in the context of the COVID-19 pandemic
Creators: name: Hutmacher, Fabian
name: Reichardt, Regina
name: Appel, Markus
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Science Policy

description: Supplemental material, sj-pdf-1-pus-10.1177_09636625211047974 for The role of motivated science reception and numeracy in the context of the COVID-19 pandemic by Fabian Hutmacher, Regina Reichardt and Markus Appel in Public Understanding of Science
Additional file 1 of A paclitaxel-hyaluronan conjugate (ONCOFID-P-B™) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the tumor microenvironment
Creators: name: Tosi, Anna
name: Parisatto, Beatrice
name: Gaffo, Enrico
name: Bortoluzzi, Stefania
name: Rosato, Antonio
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1.
sj-pdf-1-aop-10.1177_10600280211049727 – Supplemental material for Risk of Gastrointestinal Bleeding on Treatment With Statin Alone or With Concomitant Administration of Warfarin: A Systematic Review and Meta-analysis of 5.3 Million Participants
Creators: name: Bhagavathula, Akshaya Srikanth
name: Vidyasaga, Kota
name: Gebreyohannes, Eyob Alemayehu
name: Tesfaye, Wubshet
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-aop-10.1177_10600280211049727 for Risk of Gastrointestinal Bleeding on Treatment With Statin Alone or With Concomitant Administration of Warfarin: A Systematic Review and Meta-analysis of 5.3 Million Participants by Akshaya Srikanth Bhagavathula, Kota Vidyasaga, Eyob Alemayehu Gebreyohannes and Wubshet Tesfaye in Annals of Pharmacotherapy
sj-docx-1-fac-10.1177_27325016211048203 – Supplemental material for Improving Esthetic and Functional Outcomes of Severe Habsburg Jaw Using Modified Mandibular C-Osteotomies: A Case Report and Review of Literature
Creators: name: Henry, Andrew M.
name: Yu, Jason W.
name: Farrell, Brian B.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-fac-10.1177_27325016211048203 for Improving Esthetic and Functional Outcomes of Severe Habsburg Jaw Using Modified Mandibular C-Osteotomies: A Case Report and Review of Literature by Andrew M. Henry, Jason W. Yu and Brian B. Farrell in American Society of Maxillofacial Surgeons
STATO SECRETORIO DI GH E SOMATOMEDINE CIRCOLANTI NELLA TALASSEMIA: INFLUENZA SU TURNOVER E DENSITA' MINERALE OSSEA
Creators: name: CATTANEO, AGNESE
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Introduction. Previous data from our group suggested a role for the GH/IGF-I axis in the pathophysiology of osteoporosis in thalassemia (Clin Endocrinol 69:202, 2008). The present study was aimed at evaluating the relationships between circulating somatomedins and bone metabolism and density in a very large series of adult thalassemic patients. Study design. One hundred and thirty-nine patients affected by thalassemia major (mean age 32.3 � 7.87 years) underwent the following evaluations: assessment of lumbar and femoral BMD by DEXA; measurement of serum osteocalcin and CTx, and urinary NTx; measurement of serum IGF-I and IGF-II; assessment of the GH response to GHRH + arginine. Results. Lumbar osteoporosis and femoral osteoporosis were detected in 54.3% and 58.1% of patients, respectively. IGF-I was low in 86.7% of subjects, whereas none of them displayed low IGF-II. Severe GH deficiency was documented in 27.9% of subjects. In the whole group of patients, IGF-I was positively correlated with GH peak (p < 0.01), osteocalcin (p < 0.0001), CTx (p < 0.0001) and NTx (p < 0.0001), and negatively correlated with age (p < 0.0001), but was not correlated with either lumbar or femoral T-scores. No correlations were found between IGF-II and any of the above parameters, with the exception of age (negative correlation, p < 0,05). The same picture of correlations held true when considering the subset of osteoporotic patients. Conclusions. Our study confirms the high prevalence of both osteoporosis and GH/IGF-I deficiency in thalassemic adults. GH and IGF-I secretory status, but not circulating IGF-II, appears to positively affect bone turnover in this clinical condition. Further, GH secretory status, but not circulatin IGFs, is likely to influence also bone mineralization.
sj-docx-1-srd-10.1177_23780231211048023 – Supplemental material for How Asians React to Discrimination Does Not Depend on Their Party Identification
Creators: name: Leung, Kristo
name: Cheng, Ke
name: Zhang, Junyao
name: Cheng, Yipeng
name: Nguyen Cao, Viet Hung
name: Ioku, Shusuke
name: Kikuchi, Masanori
name: Long, Wen
name: Crabtree, Charles
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-srd-10.1177_23780231211048023 for How Asians React to Discrimination Does Not Depend on Their Party Identification by Kristo Leung, Ke Cheng, Junyao Zhang, Yipeng Cheng, Viet Hung Nguyen Cao, Shusuke Ioku, Masanori Kikuchi, Wen Long and Charles Crabtree in Socius
Negotiating Large Obstacles with a Humanoid Robot via Multi-Contact Motion Planning
Creators: name: KANAJAR, PAVAN
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: Incremental progress in humanoid robot locomotion over the years has achieved essential capabilities such as navigation over
at or uneven terrain, stepping over small obstacles and imbing stairls. However, the locomotion research has mostly been limited to using only bipedal gait and only foot contacts with the environment, using the upper body for balancing without considering additional external contacts. As a result, challenging locomotion tasks like climbing over large obstacles relative to the size of the robot have remained unsolved. In this paper, we address this class of open problems with an approach based on multi-contact motion planning, guided by physical human demonstrations. Our goal is to make humanoid locomotion
problem more tractable by taking advantage of objects in the surrounding environment instead of avoiding them. We propose a multi-contact motion planning algorithm for humanoid robot locomotion which exploits the multi-contacts at the upper and lower body limbs. We propose a contact stability measure, which simplies the contact search from demonstration and
contact transition motion generation for the multi-contact motion planning algorithm. The algorithm uses the whole-body motions generated via Quadratic Programming (QP) based solver methods. The multi-contact motion planning algorithm is applied for a challenging task of climbing over a relatively larger obstacle compared to the robot. We validate our
planning approach with simulations and experiments for climbing over a large wooden obstacle with COMAN, which is a complaint humanoid robot with 23 degrees of freedom (DOF). We also propose a generalization method, the \Policy-Contraction Learning Method" to extend the algorithm for generating new multi-contact plans for our multi-contact motion planner, that can adapt to changes in the environment. The method learns a general policy and the multi-contact behavior from the human demonstrations, for generating new multi-contact plans for the obstacle-negotiation.
STATISTICAL METHODS FOR THE ASSESSMENT OF WITHIN-PLAFORM REPEATABILITY AND BETWEEN-PLATFORM AGREEMENT IN MICRORNA MICROARRAY TECHNOLOGIES
Creators: name: BASSANI, NICCOLO'  PAOLO
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Over the last years miRNA microarray platforms have provided great insights in the biological mechanisms underlying onset and development of several diseases such as tumours and chronic pathologies. However, only a few studies have evaluated reliability and concordance of these technologies, mostly by using improper statistical methods.
In this project we have studied performance of three different miRNA microarray platforms (Affymetrix, Agilent and Illumina) in terms of their within-platform repeatability by means of a of random-effects model to assess contribution to overall variability from different technical sources, and interpret the quotas of explained variance as Intraclass Correlation Coefficients. Jointly, Concordance Correlation Coefficients between technical array replicates are estimated and assessed in a non-inferiority setting to further evaluate patterns of platform repeatability. Concordance between-platforms has been studied using a modifed version of the Bland-Altman plot which makes use of a linear measurement error to build the agreement intervals. All the analysis have been performed on unfiltered and non-normalized data, yet all results have been compared to those obtained after applying standard filtering procedures and quantile and loess normalization algorithms.
In this project two biological samples were considered: one tumor cell line, A498, and a pool of healthy human tissues, hREF, with three technical replicates for each platform. Our results suggest a good degree of repeatability for all the technologies considered, whereas only Agilent and Illumina show good patterns of concordance.
The proposed methods have the advantage of being very flexible, and can be useful for performance assessment of other emerging genomic platforms other than microarrays, such as RNASeq technologies.
Supplemental Material, sj-doc-3-apc-10.1177_23742895211041725 - Enhancing the Pipeline of Pathologists in the United States
Creators: name: Naritoku, Wesley Y.
name: Furlong, Mary A.
name: Knollman-Ritschel, Barbara
name: Kaul, Karen L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental Material, sj-doc-3-apc-10.1177_23742895211041725 for Enhancing the Pipeline of Pathologists in the United States by Wesley Y. Naritoku, Mary A. Furlong, Barbara Knollman-Ritschel and Karen L. Kaul in Academic Pathology
Supplemental Material, sj-docx-1-apc-10.1177_23742895211041725 - Enhancing the Pipeline of Pathologists in the United States
Creators: name: Naritoku, Wesley Y.
name: Furlong, Mary A.
name: Knollman-Ritschel, Barbara
name: Kaul, Karen L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental Material, sj-docx-1-apc-10.1177_23742895211041725 for Enhancing the Pipeline of Pathologists in the United States by Wesley Y. Naritoku, Mary A. Furlong, Barbara Knollman-Ritschel and Karen L. Kaul in Academic Pathology
Supplementary Material 1 - Supplemental material for The Impact of Training on Human–Autonomy Team Communications and Trust Calibration
Creators: name: Johnson, Craig J.
name: Demir, Mustafa
name: McNeese, Nathan J.
name: Gorman, Jamie C.
name: Wolff, Alexandra T.
name: Cooke, Nancy J.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary Material 1, for The Impact of Training on Human–Autonomy Team Communications and Trust Calibration by Craig J. Johnson, Mustafa Demir, Nathan J. McNeese, Jamie C. Gorman, Alexandra T. Wolff and Nancy J. Cooke in Human Factors: The Journal of Human Factors and Ergonomics Society
SINTESI DI NUOVE MOLECOLE PER IL TRATTAMENTO DI PATOLOGIE INFIAMMATORIE
Creators: name: TAZZARI, VALERIO
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Recently, the role of hydrogen sulphide (H2S) a well known toxic gas with reducing properties has received a great interest. It has been found that H2S is produced in consistent quantity in the mammalian tissues and it exerts several physiological effects that suggest its role as a regulating mediator. H2S is involved in the regulation of the muscular tone, of the myocardial contractility, in the inflammatory processes, in the neurotransmission and in insulin secretion. Reduced levels of H2S were observed in several animal models of artery and pulmonary hypertension, damages of gastric mucosa and hepatic cirrhosis. Exogenous H2S inhibits inflammation, improves cardiac dysfunctions associated to ischemia/reperfusion and reduces the gastric damage induced by anti-inflammatory drugs. On the other hand, if not properly controlled and in excessive doses, endogenous H2S may contribute to tissue inflammation through stimulation of related converting enzymes (CBA and CBS).
H2S has also an active role in the redox imbalance processes. In particular this gas mediator influences the activation of cellular inflammatory processes interacting with signalling mechanisms, transcription factors and neutralizing ROS. Moreover it has been reported that it has cytoprotective properties due to GSH production in several tissues.
On this basis, it is clear the utility of molecules capable to modulate the plasma and tissue concentration of H2S especially in pathologies characterised by disorders of GSH homeostasis and increase of oxidative stress as it happens in neurodegenerative diseases, cystic fibrosis and other severe lung pathologies, but also in cardiovascular diseases (such as metabolic syndrome) etc.
An interesting and innovative approach is the synthesis of hybrid molecules that combine the structure of a known drug with a sulfurated moiety able to in vivo slowly release H2S. Therefore, the purpose of this thesis was the synthesis of hybrid compounds active in neurodegenerative diseases (PD), such as sulfurated derivatives of L-DOPA and H2S-releasing drugs active on the peripheral circulatory system, such as sulfurated derivatives of phosphodiesterase 5 (PDE-5) inhibitors, in order to improve the efficacy and tolerability of the parent compound. Cysteine hybrid compounds coupled to dithiolethiones, addressed to treatment of specific metabolic conditions such as hyperhomocysteinemia, were also synthesized.
The pharmacological studies conducted until now show that the H2S-releasing drugs, described in this thesis, by in vivo H2S releasing and modulating, have important antioxidant, anti-inflammatory and cytoprotective properties, while maintaining the pharmacological profile of the original drug. These data confirm the potential usefulness of new compounds in the treatment of many different diseases in which there is an inflammatory and / or a redox imbalance component.
sj-pdf-1-het-10.1177_09603271211047915 – Supplemental Material for Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2
Creators: name: Wang, Guangju
name: Bi, Yajuan
name: Xiong, Hui
name: Bo, Tongwei
name: Han, Lifeng
name: Zhou, Lijun
name: Zhang, Chunze
name: Zhang, Youcai
Publisher: name: SAGE Journals
Year: 2021
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental Material, sj-pdf-1-het-10.1177_09603271211047915 for Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2 by Guangju Wang, Yajuan Bi, Hui Xiong, Tongwei Bo, Lifeng Han, Lijun Zhou, Chunze Zhang and Youcai Zhang in Human & Experimental Toxicology
sj-docx-1-pss-10.1177_0956797621997350 – Supplemental material for Sex, Drugs, and Genes: Illuminating the Moral Condemnation of Recreational Drugs
Creators: name: Karinen, Annika K.
name: Wesseldijk, Laura W.
name: Jern, Patrick
name: Tybur, Joshua M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-docx-1-pss-10.1177_0956797621997350 for Sex, Drugs, and Genes: Illuminating the Moral Condemnation of Recreational Drugs by Annika K. Karinen, Laura W. Wesseldijk, Patrick Jern and Joshua M. Tybur in Psychological Science
sj-pdf-2-pic-10.1177_09544062211027608 - Supplemental material for Optimization of the centrifugal slurry pump through the splitter blades position
Creators: name: Abdolahnejad, Ehsan
name: Moghimi, Mahdi
name: Derakhshan, Shahram
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-2-pic-10.1177_09544062211027608 for Optimization of the centrifugal slurry pump through the splitter blades position by Ehsan Abdolahnejad, Mahdi Moghimi and Shahram Derakhshan in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science
SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT
Creators: name: PISANI, LAURA FRANCESCA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: The aims of the work presented in this thesis were to investigate the bovine acute phase protein Serum Amyloid A, focussing on its value as safety marker in farm animals.

SAA can be considered as a natural anti-inflammatory and immunomodulatory agent and local expression of SAA, at the site of the initial acute phase reaction, could protect against the deleterious effects of inflammation.

In this study whether SAA can be isolated from tissues of bovine with clinical amyloidosis was investigated. We also investigated if AA fibrils present in milk can be then found in cheese after caseification, i.e. if the process of ripeining can degrade the AA fibrils.

In bovine, SAA was identified as potential marker of mastitis, and SAA milk concentration in milk increases before the raising of somatic cells.

In this thesis two aspect of the involvement of SAA in food safety were explored:
a)the acute phase reaction, strongly focused on the mammary gland. The animal model chosen was water buffalo, since no information is available so far about the acute phase reaction in this species. The acute phase proteins sequences are unknown, and also their concentration in physiological and pathological conditions are not established.
b)The possibility that high concentration of SAA in milk induce the formation of amyloid fibrils, which are considered to be potentially dangerous for human safety.

Results presented in this thesis advanced the knowledge of the acute phase reaction in water buffalo: the five APPs included in this investigation, namely Serum amyloid A, Haptoglobin, Ceruloplasmin, ?1-acid glycoprotein and Lipolysaccaride Binding Protein were sequenced for the first time, and two of them were quantified.
In the second part of the thesis, we purified amyloid fibrils from amyloidosis-affected cows, and added purified fibrils at a given concentration in milk before ripening.
Results demonstrated the presence of insoluble fibrils in cheese added with amyloid proteins, even if a lower amount of precipitated insoluble SAA could be detected also in negative control cheese.
Energy management and guidelines to digitalisation of integrated natural gas distribution systems equipped with expander technology
Creators: name: LO CASCIO, ERMANNO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: In a swirling dynamic interaction, digital innovation, environment and
anthropological evolution are swiftly shaping the smart grid scenario. Integration
and flexibility are the keywords in this emergent picture characterised by a low
carbon footprint. Digitalisation, within the natural limits imposed by the
thermodynamics, seems to offer excellent opportunities for these purposes. Of
course, here starts a new challenge: how digital technologies should be employed
to achieve these objectives? How would we ensure a digital retrofit does not lead to
a carbon emission increase? In author opinion, as long as it remains a generalised
question, none answer exists: the need to contextualise the issue emerges from the
variety of the characteristics of the energy systems and from their interactions with
external processes. To address these points, in the first part of this research, the
author presented a collection of his research contributions to the topic related to the
energy management in natural gas pressure reduction station equipped with turbo
expander technology. Furthermore, starting from the state of the art and the author's
previous research contributions, the guidelines for the digital retrofit for a specific
kind of distributed energy system, were outlined. Finally, a possible configuration
of the ideal ICT architecture is extracted. This aims to achieve a higher level of
coordination involving, natural gas distribution and transportation, local energy
production, thermal user integration and electric vehicles charging. Finally, the
barriers and the risks of a digitalisation process are critically analysed outlining in
this way future research needs.
Experimental Study, In-situ Measurement and Modeling for Laser Based Additive and Subtractive Manufacturing
Creators: name: Song, Hanyu
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Mechanical engineering not elsewhere classified

description: Research work on laser sintering of carbon nanotube (CNT)-metal composites on a polymer substrate is reported, using a continuous-wave laser or a nanosecond (ns)-pulsed laser. Multiple approaches are employed, such as in-situ temperature measurements through fast pyrometry, in-situ reflected probe laser beam measurement, and post-process electrical resistivity measurement and microscopic characterizations for sintered material. The results are analyzed and discussed.A novel laser micro sintering (LMS) process, with the name of “double-pulse laser micro sintering” (DP-LMS), has been studied. DP-LMS utilizes laser pulse group(s) consisting of“sintering laser pulse(s)” followed by “pressing laser pulse(s)” at a suitable delay time. Under the studied conditions, DP-LMS can produce an improved sintering result than those by LMS under similar conditions without using the “double-pulse” approach. The underlying mechanism for the effect of the “pressing laser pulse” delay time has been analyzed with the help of in-situ time resolvedmeasurements of powder bed surface temperatures during DP-LMS.A preliminary experimental study on a laser metal deposition (LMD) process, called warm ultrasonic impact-assisted laser metal deposition (WUI-LMD), has also been reported (such a study has been rarely seen in literature to our knowledge). During WUI-LMD, in-situ ultrasonic impact treatment is applied on laser-deposited material at elevated temperatures. The preliminary results show that for the conditions and samples studied, the WUI-LMD process can effectively reduce the porosity of the deposited material. This implies its great potential for improving the LMD process without obviously increasing the total production time.A novel laser-induced plasma deburring (LPD) process was reported in a previous preliminary experimental study. However, the burr removal mechanism in the previous LPDexperiment still requires further study to understand. In this study, a physics-based model is developed for laser-induced plasma flow and plasma-burr interactions. Under the conditions studied, it has been found that the plasma-induced thermal effect on the burr is unlikely to play a major role in the burr removal. Instead, the high pressure induced by the plasma on the burr can induce stresses potentially large enough to remove the burr. Therefore, the burr removal should be mainly through a mechanical mechanism instead of a thermal mechanism during the LPD process under the conditions studied.
Rare and endangered linguistic subsystems in Celtic and Welsh
Creators: name: PHILLIPS, JOHN D.
Publisher: name: Universit� degli studi di Bergamo
Year: 2007

description: Nelle lingue celtiche si osservano numerosi tratti rari e interessanti sul piano interlinguistico, ma tutti questi tratti sono minacciati dal numero sempre pi� basso di parlanti attivi. Ad esempio, nel caso del gallese, sebbene di recente questa lingua abbia mostrato segni di ripresa, le sue caratteristiche morfosintattiche pi� specifiche sembrano in declino oppure gi� estinte nell?uso dei parlanti pi� giovani. Questo contributo prende in considerazione alcune strutture delle lingue celtiche, il loro attuale stato di pericolo, e il caso di alcuni recenti sviluppi osservati in gallese.
Un dimenticato problema ecdotico del Muspilli: le trascrizioni di Docen, Ma�mann e Schmeller
Creators: name: SANTORO, VERIO
Publisher: name: Universit� degli studi di Bergamo
Year: 2007

description: I problemi di costituzione del testo del Muspilli si sono manifestati in tutta la loro densit� sin dall?editio princeps di Schmeller (1832). La stessa storia editoriale del componimento ha poi aggiunto, alla gi� lunga teoria dei problemi testuali esistenti (precario stato di conservazione del manoscritto, l?incertezza del testo, i suoi numerosi loci critici), ulteriori difficolt�. In questo saggio si analizzano tre differenti trascrizioni del Muspilli realizzate da Docen, Ma�mann e Schmeller tra il 1817 e il 1832. Ritenute da von Steinmeyer (1892 e 1916) di scarso significato critico-testuale, queste tre trascrizioni sono state col tempo dimenticate. Il presente saggio ne mostra al contrario il loro indiscutibile valore ecdotico.
Contact vs. internal dynamics in the typological shift of English
Creators: name: BERTACCA, ANTONIO
Publisher: name: Universit� degli studi di Bergamo
Year: 2007

description: Il passaggio dell?inglese dal tipo flessivo a quello analitico � stato spesso attribuito al contatto con le variet� celtiche o con quelle dei popoli che successivamente invasero l?Inghilterra (Scandinavi e Normanni). Tuttavia, l?influenza di quelle lingue sembra essere stata marginale dal punto di vista delle conseguenze che esse ebbero sulle strutture (diverso, ovviamente, � il caso del lessico) e tale cambiamento tipologico fu dovuto piuttosto ad una lunga e complessa serie di processi fonologici naturali che, come spesso succede, ebbero conseguenze catastrofiche sulla morfologia. Del resto, gi� il proto-germanico aveva un numero di categorie morfologiche inferiore rispetto all?indoeuropeo. In questo articolo, l?autore sostiene che l?inglese antico era in uno stato di equilibrio instabile e che il contatto pu�, al massimo, aver accelerato il passaggio al tipo analitico. Tali cambiamenti morfologici e tipologici possono essere spiegati applicando la Morfologia naturale e la Teoria della Complessit�.
Relations Encoded in Multiway Arrays
Creators: name: Katz, David W
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Algebra and number theory
Algebraic and differential geometry

description: Unlike matrix rank, hypermatrix rank is not lower semi-continuous. As a result, optimal low rank approximations of hypermatrices may not exist. Characterizing hypermatrices without optimal low rank approximations is an important step in implementing algorithms with hypermatrices. The main result of this thesis is an original coordinate-free proof that real 2 by 2 by 2 tensors that are rank three do not have optimal rank two approximations with respect to the Frobenius norm. This result was previously only proved in coordinates. Our coordinate-free proof expands on prior results by developing a proof method that can be generalized more readily to higher dimensional tensor spaces. Our proof has the corollary that the nearest point of a rank three tensor to the second secant set of the Segre variety is a rank three tensor in the tangent space of the Segre variety. The relationship between the contraction maps of a tensor generalizes, in a coordinate-free way, the fundamental relationship between the rows and columns of a matrix to hypermatrices. Our proof method demonstrates geometrically the fundamental relationship between the contraction maps of a tensor. For example, we show that a regular real or complex tensor is tangent to the 2 by 2 by 2 Segre variety if and only if the image of any of its contraction maps is tangent to the 2 by 2 Segre variety.
SCOMPARIRE DAL MONDO: LA PARABOLA ARTISTICA DI ROBERT WALSER
Creators: name: ASCOLESE, SARA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Disappearing from the world: Robert Walser's artistic path. The aim of my thesis is to explain why Robert Walser decided to disappear from the real and from the artistic wolrd spending the last thirty years of his life in a psychiatric clinic. Subjects of my thesis are: nonconformity, anti-Bildungsroman, the will to be small and to serve, the walk, the microgramms and the illness and at the end Robert Walser's poetry and style.