cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effect of hydroxyurea on erythrocyte apoptosis in hemoglobinopathy patients
Creators: name: Kargutkar, Neha
name: Nadkarni, Anita
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Hydroxyurea (HU) therapy improves the clinical severity of patients with hemoglobinopathies. Few studies have documented some mechanisms of HU, but the exact mechanism of action is unknown. Phosphatidylserine on erythrocytes is responsible for apoptosis. In this study, we investigate the expression of phosphatidylserine on the erythrocytes surface of hemoglobinopathies before and after HU treatment. Blood samples from 45 thalassemia intermedia and 40 SCA and 30 HbE-b-thalassemia patients were analyzed before and after 3 and 6 months of HU treatment. The profile of phosphatidylserine was determined by flow-cytometry using the Annexin V-RBC apoptosis kit. Hydroxyurea proved effective in improving clinical severity of hemoglobinopathies. After treatment with hydroxyurea, the percentage of phosphatidylserine-positive cells was significantly reduced in all 3 patient groups (p < 0.0001). Correlation analysis using different hematological parameters as independent variables and % phosphatidylserine as dependent variable showed a negative relationship with HbF, RBC, and hemoglobin in all 3 patient groups. Hydroxyurea reduces the expression of phosphatidylserine on erythrocytes, contributing to the beneficial effects of this therapy. We suggest that the use of such a biological marker in conjunction with HbF levels may provide valuable insights into the biology and consequences of early RBC apoptosis. The study investigated the role of hydroxyurea in reducing the externalization of phosphatidylserine on the surface of the erythrocyte membrane of patients with hemoglobinopathies. In patients treated with hydroxyurea for 3 and 6 months, the percentage of phosphatidylserine exposure on the erythrocyte surface was reduced compared with baseline. The decreased percentage of phosphatidylserine correlated negatively with hematologic parameters such as red blood cell (RBC), hemoglobin, and fetal hemoglobin (HbF) in patients at baseline and after HU therapy. Treatment with hydroxyurea decreases the percentage of PS exposure on the surface of RBCs, contributing to the beneficial effects of this therapy. We, therefore, suggest that the use of such a biological marker on the erythrocyte cell surface in conjunction with HbF levels may provide valuable insights into the biology and consequences of early erythrocyte apoptosis.
Complementary and Alternative Medicine Use at a Comprehensive Cancer Center
Creators: name: Asher, Gary N.
name: Luo, Qianlai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Background. Complementary and alternative medicine (CAM) use is common among cancer patients, but the majority of CAM studies do not specify the time periods in relation to cancer diagnoses. We sought to define CAM use by cancer patients and investigate factors that might influence changes in CAM use in relation to cancer diagnoses. Methods. We conducted a cross-sectional survey of adults diagnosed with breast, prostate, lung, or colorectal cancer between 2010 and 2012 at the Lineberger Comprehensive Cancer Center. Questionnaires were sent to 1794 patients. Phone calls were made to nonrespondents. Log binomial/Poisson regressions were used to investigate the association between cancer-related changes in CAM use and conversations about CAM use with oncology providers. Results. We received 603 (33.6 %) completed questionnaires. The mean age (SD) was 64 (11) years; 62% were female; 79% were white; and 98% were non-Hispanic. Respondents reported the following cancer types: breast (47%), prostate (27%), colorectal (14%), lung (11%). Eighty-nine percent reported lifetime CAM use. Eighty-five percent reported CAM use during or after initial cancer treatment, with category-specific use as follows: mind-body medicine 39%, dietary supplements 73%, body-based therapies 30%, and energy medicine 49%. During treatment CAM use decreased for all categories except energy medicine. After treatment CAM use returned to pretreatment levels for most CAMs except chiropractic. Initiation of CAM use after cancer diagnosis was positively associated with a patient having a conversation about CAM use with their oncology provider, mainly driven by patient-initiated conversations. Conclusions. Consistent with previous studies, CAM use was common among our study population. Conversations about CAM use with oncology providers appeared to influence cessation of mind-body medicine use after cancer diagnosis.
Effect of hydroxyurea on erythrocyte apoptosis in hemoglobinopathies patients
Creators: name: Kargutkar, Neha
name: Nadkarni, Anita
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Hydroxyurea (HU) therapy improves the clinical severity of patients with hemoglobinopathies. Few studies have documented some mechanisms of HU, but the exact mechanism of action is unknown. Phosphatidylserine on erythrocytes is responsible for apoptosis. In this study, we investigate the expression of phosphatidylserine on the erythrocytes surface of hemoglobinopathies before and after HU treatment. Blood samples from 45 thalassemia intermedia and 40 SCA and 30 HbE-β-thalassemia patients were analyzed before and after 3 and 6 months of HU treatment. The profile of phosphatidylserine was determined by flow-cytometry using the Annexin V-RBC apoptosis kit. Hydroxyurea proved effective in improving clinical severity in hemoglobinoapathies. After treatment with hydroxyurea, the percentage of phosphatidylserine-positive cells was significantly reduced in all 3 patient groups (p < 0.0001). Correlation analyses using different hematological parameters as independent variables and % phosphatidylserine as dependent variable showed a negative relationship with HbF, RBC and hemoglobin in all 3 patient groups Hydroxyurea reduces the expression of phosphatidylserine on erythrocytes, contributing to the beneficial effects of this therapy. We suggest that the use of such a biological marker in conjunction with HbF levels may provide valuable insights into the biology and consequences of early RBC apoptosis. The study investigated the role of hydroxyurea in reducing the externalization of phosphatidylserine on the surface of the erythrocyte membrane of patients with hemoglobinopathies. In patients treated with hydroxyurea for 3 and 6 months, the percentage of phosphatidylserine exposure on the erythrocyte surface was reduced compared with baseline. The decreased percentage of phosphatidylserine correlated negatively with hematologic parameters such as red blood cell (RBC), hemoglobin, and fetal hemoglobin (HbF) in patients at baseline and after HU therapy. Treatment with hydroxyurea decreases the percentage of PS exposure on the surface of RBCs, contributing to the beneficial effects of this therapy. We, therefore, suggest that the use of such a biological marker on the erythrocyte cell surface in conjunction with HbF levels may provide valuable insights into the biology and consequences of early erythrocyte apoptosis.
Exploration of the effects of classroom humidity levels on teachers’ respiratory symptoms
Creators: name: Angelon-Gaetz, Kim A.
name: Marshall, Stephen W.
name: Richardson, David B.
name: Hernandez, Michelle L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Previous studies indicate that teachers have higher asthma prevalence than other non-industrial worker groups. Schools frequently have trouble maintaining indoor relative humidity (RH) within the optimum range (30-50%) for reducing allergens and irritants. However, the potential relationship between classroom humidity and teachers’ health has not been explored. Thus, we examined the relationship between classroom humidity levels and respiratory symptoms among North Carolina teachers.
Service and demographic factors, health, trauma exposure, and participation are associated with adjustment for former Australian Defense Force members
Creators: name: Carra, Kylie
name: Curtin, Michael
name: Fortune, Tracy
name: Gordon, Brett
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Approximately 50% of transitioning service members report difficulty adjusting to civilian life. However, there is limited research exploring factors that influence adjustment for former Australian Defence Force (ADF) members. The aim of this study was to investigate the influence of demographic and service-related characteristics, trauma exposure, health, and participation in meaningful occupations on adjustment for former ADF members. One hundred and ninety-eight former ADF members completed a voluntary, online survey containing validated self-report measures for adjustment, health, and exposure to combat and military sexual trauma. Participation in meaningful occupations was assessed using open-ended questions and a rating scale for frequency of participation. A more difficult adjustment was reported by participants who had completed operational service, reported exposure to combat and/or military sexual trauma, had poor physical health and were discharged for medical reasons. Other characteristics associated with a difficult adjustment included emotional distress, involuntary discharge, age category 30–49 years, final rank of Senior Noncommissioned Officer/Warrant Officer or below, and discharge 6–8 years previously. Employment, voluntary work and care, and social and community interaction were associated with an easier adjustment. Screening tools that consider health, age, deployment type, final rank, type of discharge and exposure to combat or military sexual trauma may be helpful to identify and refer high risk individuals to employment, rehabilitation or transition support programs.
Electrophoretic deposition of carbon nanotubes: recent progress and remaining challenges
Creators: name: Rehman, Muhammad Atiq Ur
name: Chen, Qianq
name: Braem, Annabel
name: Shaffer, Milo S. P.
name: Boccaccini, Aldo R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Electrophoretic deposition (EPD) is a powerful technique to assemble carbon nanotube (CNT) coatings and composite films with controlled architectures. This comprehensive review of the EPD of CNTs and CNT-containing composites focuses on achievements within the last 15 years and ongoing challenges. Stable CNT suspensions are a pre-requisite for successful EPD and have been prepared by a variety of strategies, discussed here. The resulting film microstructure is determined by the initial feedstock, the suspension, and the EPD approach applied, as well as a variety of EPD processing parameters. Nanocomposites can be prepared via co-deposition, sequential deposition, or post-deposition treatments, to introduce metallic, ceramic or polymeric phases. There are numerous potential applications for both homogeneous and patterned CNT films, including as structural reinforcements for composites, as field emission, energy storage and conversion devices, as well as in biomedical applications. The advantages and disadvantages of EPD processing in these contexts are discussed.
Educational utility of advanced three-dimensional virtual imaging in evaluating the anatomical configuration of the frontal recess: Educational Utility of 3D Imaging Software For Frontal Recess Anatomy
Creators: name: Senior, Brent
name: Siow, Jin Keat
name: Citardi, Martin J.
name: Luong, Amber
name: Szczygielski, Kornel
name: Agbetoba, Abib
name: Callejas, Claudio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Endoscopic sinus surgery represents a cornerstone in the professional development of otorhinolaryngology trainees. Mastery of these surgical skills requires an understanding of paranasal sinus and skull base anatomy. The frontal sinus is associated with a wide range of variation and complex anatomical configuration, and thus represents an important challenge for all trainees performing endoscopic sinus surgery.
Spousal migration and human papillomavirus infection among women in rural western Nepal
Creators: name: Shrestha, Sadeep
name: Johnson, Derek C.
name: Lhaki, Pema
name: Vermund, Sten H.
name: Smith, Jennifer S.
name: Regmi, Kiran
name: Aryal, Shilu
name: Chamot, Eric
name: Bhatta, Madhav P.
name: Bhattarai, Pankaj
name: Kempf, Mirjam-Colette
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In April 2014 we investigated the association of migration of a woman's husband with her high-risk human papillomavirus (HR-HPV) infection status and her abnormal cervical cytology status in the Achham district of rural Far-Western Nepal.
Implementing the 5 A’s to promote behavior change and weight loss in overweight and obese adults
Creators: name: Puerta, Tatiana
Publisher: name: No Publisher Supplied
Year: 2022

description: Purpose of Project: Obesity is one of the leading public health problems in the world today withincreasing morbidity and mortality from obesity-related comorbidities and preventable complications. The use of behavioral interventions such as the 5 A’s framework of obesity management is recommended by national healthcare organizations that found evidence of clinically significant improvements in weight loss and behavior change outcomes. Despite the evidence-based recommendations, there is a gap in the clinical practice of obesity management. The purpose of this quality improvement project is to improve health outcomes and quality of life in overweight and obese adults by promoting weight loss and behavior change using behavioral interventions. Methodology: This quality improvement project used a longitudinal approach with qualitative and quantitative data collection. The sample was composed of 13 English-speaking participants, male and female, between the ages of 18 and 70 years old, who were overweight or obese, and had an email account. The intervention was implementing the 5 A’s framework along with a weight loss strategy that took place once a week in a 1-hour webinar, for 8 weeks. A questionnaire was administered and collected electronically during week 1 (baseline), week 4, and week 8 after the weekly webinar meeting. Results: Both weight and BMI showed a statistically significant decrease over the 8-week study period (p<0.001 for both). Participants lost an average of 8.96 ± 5.68 pounds and had an average decrease in BMI of 1.45 ± 1.00 points. At least half of the participants (53.8%) reached the weight reduction goal of at least 5% of their initial body weight. Participant behaviors related to exercise, diet, and psychological habits showed statistically significant improvements over the study period as well. Implications for Practice: This study sheds light on the gap in clinical practice that overlooks the need for healthcare providers to address and manage obesity as a chronic disease. Recommendations for healthcare providers to use behavioral interventions like the 5 A’s framework should be implemented into clinical practice. Further research is warranted on improving obesity management along with a change in healthcare policy to see changes in practice.
Chronic disease self-management education courses: utilization by low-income, middle-aged participants
Creators: name: Smith, Matthew Lee
name: Kneipp, Shawn M.
name: Towne, Samuel D.
name: Mingo, Chivon A.
name: Ahn, Sangnam
name: Horrell, Lindsey N.
name: Ory, Marcia G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Individuals living in lower-income areas face an increased prevalence of chronic disease and, oftentimes, greater barriers to optimal self-management. Disparities in disease management are seen across the lifespan, but are particularly notable among middle-aged adults. Although evidence-based Chronic Disease Self-management Education courses are available to enhance self-management among members of this at-risk population, little information is available to determine the extent to which these courses are reaching those at greatest risk. The purpose of this study is to compare the extent to which middle-aged adults from lower- and higher-income areas have engaged in CDSME courses, and to identify the sociodemographic characteristics of lower-income, middle aged participants.

METHODS: The results of this study were produced through analysis of secondary data collected during the Communities Putting Prevention to Work: Chronic Disease Self-Management Program initiative. During this initiative, data was collected from 100,000 CDSME participants across 45 states within the United States, the District of Columbia, and Puerto Rico.

RESULTS: Of the entire sample included in this analysis (19,365 participants), 55 people lived in the most impoverished counties. While these 55 participants represented just 0.3% of the total study sample, researchers found this group completed courses more frequently than participants from less impoverished counties once enrolled.

CONCLUSION: These results signal a need to enhance participation of middle-aged adults from lower-income areas in CDSME courses. The results also provide evidence that can be used to inform future program delivery choices, including decisions regarding recruitment materials, program leaders, and program delivery sites, to better engage this population.
La cytométrie en flux : un nouvel outil diagnostique en hématologie
Creators: name: BRAHAM-JMILI, N.
name: JACOB, MC.
Publisher: name: Revue Tunisienne de Biologie Clinique
Year: 2024

description: La cytométrie en flux est un procédé d’analyse biologique basé sur l’analyse des caractéristiques physiques de particules distinctes défilant l’une derrière l’autre dans un flux de liquide par le biais de trois systèmes : fluidique, optique et informatique. Cette analyse est précédée d’une étape de marquage avec des molécules spécifiques d’une structure ou d’une fonction cellulaire, ces molécules étant susceptibles d’émettre une fluorescence après leur excitation par un faisceau laser, le plus employé étant le laser à argon. Les signaux de diffusion et de fluorescence (photons) sont captés par des détecteurs qui les transforment en signaux électriques qui seront traités par un système informatique. La cytométrie en flux a investi un champ d’application très large en hématologie : l’immunophénotypage des hémopathies, la détection de la maladie résiduelle, la numération des réticulocytes, le diagnostic de l’hémoglobinurie paroxystique nocturne. Ses champs d’applications en immuno-hématologie sont multiples, notamment la numération des cellules souches. D’autre part l’étude du cycle cellulaire a permis de mieux comprendre les facteurs contrôlant l’apoptose.
description: Revue Tunisienne de Biologie Clinique, No 20 (2007): Revue Tunisienne de Biologie Clinique
Additional file 10 of Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought
Creators: name: Ebeed, Heba Talat
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 10: Table S9. Primer sequences used in the study for wheat PAs genes.
A Variational EM Algorithm for the Separation of Time-Varying Convolutive Audio Mixtures
Creators: name: Kounades-Bastian, Dionyssos
name: Girin, Laurent
name: Alameda-Pineda, Xavier
name: Gannot, Sharon
name: Horaud, Radu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Sound (cs.SD)
subject: FOS: Computer and information sciences

description: This paper addresses the problem of separating audio sources from time-varying convolutive mixtures. We propose a probabilistic framework based on the local complex-Gaussian model combined with non-negative matrix factorization. The time-varying mixing filters are modeled by a continuous temporal stochastic process. We present a variational expectation-maximization (VEM) algorithm that employs a Kalman smoother to estimate the time-varying mixing matrix, and that jointly estimate the source parameters. The sound sources are then separated by Wiener filters constructed with the estimators provided by the VEM algorithm. Extensive experiments on simulated data show that the proposed method outperforms a block-wise version of a state-of-the-art baseline method.
description: 13 pages, 4 figures, 2 tables
Coordinated semi-adaptive closed-loop control for infusion of two interacting medications
Creators: name: Kim, Chang-Sei
name: Shipley, Steven T.
name: Dumont, Guy A.
name: Jin, Xin
name: Hahn, Jin-Oh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: This paper presents a coordinated and semi‐adaptive closed‐loop control approach to the infusion of 2 interacting medications. The proposed approach consists of an upper‐level coordination controller and a lower‐level semi‐adaptive controller. The coordination controller recursively adjusts the reference targets based on the estimated dose‐response relationship of a patient to ensure that they can be achieved by the patient. The semi‐adaptive controller drives the patient outputs to the reference targets while estimating the patient's dose‐response relationship online. In this way, the controller is resilient to unachievable caregiver‐specified reference targets and responsive to the medication needs of individual patients. To establish the proposed approach, we developed the following: (1) a linear two‐input–two‐output dose‐response model; (2) a two‐input–two‐output semi‐adaptive controller to regulate the patient outputs while adapting high‐sensitivity parameters in the patient model; and (3) a coordination controller to adjust the reference targets that reconcile caregiver inputs and medication use. The proposed approach was applied to an example scenario in which cardiac output and respiratory rate are regulated via infusion of propofol and remifentanil in an in silico simulation setting. The results show that the coordinated semi‐adaptive control could (1) track achievable reference targets with consistent transient and steady‐state performance and (2) resiliently adjust the unachievable reference targets to achievable ones.
SIMILARITIES AND DIFFERENCES BETWEEN THE WORKS "BOBURNOMA" AND "BOBURIYNOMA"
Creators: name: Tojiddinova, Sitora
Publisher: name: Zenodo
Year: 2025

description: This article examines the works of the king and poet Zahiriddin Muhammad Bobur’s “Boburnoma” and the renowned writer Xayriddin Sulton’s “Boburiynoma” from a textual-comparative perspective. The common points between these works are analyzed.
Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii
Creators: name: Rao, Gauri G.
name: Bulitta, Jürgen B.
name: Forrest, Alan
name: Diep, John
name: Li, Jian
name: Ly, Neang S.
name: Tsuji, Brian T.
name: Holden, Patricia N.
name: Nation, Roger L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The prevalence of heteroresistant Acinetobacter baumannii is increasing. Infections due to these resistant pathogens pose a global treatment challenge. Here, the pharmacodynamic activities of polymyxin B (PMB) (2–20 mg/L) and tigecycline (0.15–4 mg/L) were evaluated as monotherapy and in combination using a 4 × 4 concentration array against two carbapenem-resistant and polymyxin-heteroresistant A. baumannii isolates. Time Kill Experiments was employed at starting inocula of 106 and 108 CFU/mL over 48 h. Clinically relevant combinations of PMB (2 mg/L) and tigecycline (0.90 mg/L) resulted in greater reductions in the bacterial population compared with polymyxin alone by 8 h (ATCC 19606, −6.38 vs. −3.43 log10 CFU/mL; FADDI AB115, −1.38 vs. 2.08 log10 CFU/mL). At 10× the clinically achievable concentration (PMB 20 mg/L in combination with tigecycline 0.90 mg/L), there was bactericidal activity against FADDI AB115 by 4 h that was sustained until 32 h, and against ATCC 19606 that was sustained for 48 h. These studies show that aggressive polymyxin-based dosing in combination with clinically achievable tigecycline concentrations results in early synergistic activity that is not sustained beyond 8 h, whereas combinations with higher tigecycline concentrations result in sustained bactericidal activity against both isolates at both inocula. These results indicate a need for optimised front-loaded polymyxin-based combination regimens that utilise high polymyxin doses at the onset of treatment to achieve good pharmacodynamic activity whilst minimising adverse events.
Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant  Acinetobacter baumannii
Creators: name: Forrest, Alan
name: Gall, Jonathan S.
name: Landersdorfer, Cornelia B.
name: Tsuji, Brian T.
name: Lenhard, Justin R.
name: Li, Jian
name: Thamlikitkul, Visanu
name: Nation, Roger L.
name: Bulitta, Jurgen B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The objective of this study was to determine the comparative pharmacodynamics of four different carbapenems in combination with polymyxin B (PMB) against carbapenem-resistant Acinetobacter baumannii isolates using time–kill experiments at two different inocula. Two A. baumannii strains (03-149-1 and N16870) with carbapenem minimum inhibitory concentrations (MICs) ranging from 8 to 64 mg/L were investigated in 48-h time–kill experiments using starting inocula of 106 CFU/mL and 108 CFU/mL. Concentration arrays of ertapenem, doripenem, meropenem and imipenem at 0.25×, 0.5×, 1×, 1.5× and 2× published maximum serum concentration (Cmax) values (Cmax concentrations of 12, 21, 48 and 60 mg/L, respectively) were investigated in the presence of 1.5 mg/L PMB. Use of carbapenems without PMB resulted in drastic re-growth. All carbapenem combinations were able to achieve a ≥3 log10 CFU/mL reduction by 4 h against both strains at 106 CFU/mL, whereas maximum reductions against strain 03-149-1 at 108 CFU/mL were 1.0, 3.2, 2.2 and 3.3 log10 CFU/mL for ertapenem, doripenem, meropenem and imipenem, respectively. None of the combinations were capable of reducing 108 CFU/mL of N16870 by ≥2 log10 CFU/mL. Ertapenem combinations consistently displayed the least activity, whereas doripenem, meropenem and imipenem combinations had similar activities that were poorly predicted by carbapenem MICs. As doripenem, meropenem, or imipenem displayed similar pharmacodyanmics in combination, the decision of which carbapenem to use in combination with PMB may be based on toxicodynamic profiles if drastic discordance in MICs is not present.
Additional file 6 of Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought
Creators: name: Ebeed, Heba Talat
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 6: Table S5. The significant prediction of subcellular location for Arabidopsis and wheat PA biosynthesis proteins.
Probing excitations in insulators via injection of spin-currents
Creators: name: Chatterjee, Shubhayu
name: Sachdev, Subir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We propose a spin transport experiment to measure the low-energy excitations in insulators with spin degrees of freedom, with a focus on detecting ground states that lack magnetic order. A general formalism to compute the spin-current from a metal with a non-equilibrium distribution of spins to an insulator is developed. It is applied to insulating states with and without long range magnetic order, and salient features in the spin-conductance are noted.
description: 21+4 pages, 4 figures. A few typos edited and references added, results unchanged
Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation
Creators: name: Palachanis, Dimitrios
name: Szabó, András
name: Merks, Roeland M. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cell Behavior (q-bio.CB)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Computational modelling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the Cellular Potts model (CPM) proposed that elongated, adhesive or mutually attractive endothelial cells suffice for the formation of blood vessel sprouts and vascular networks. Because each mathematical representation of a model introduces potential artifacts, it is important that model results are reproduced using alternative modelling paradigms. Here, we present a lattice-free, particle-based simulation of the cell elongation model of vasculogenesis. The new, particle-based simulations confirm the results obtained from the previous Cellular Potts simulations. Furthermore, our current findings suggest that the emergence of order is possible with the application of a high enough attractive force or, alternatively, a longer attraction radius. The methodology will be applicable to a range of problems in morphogenesis and noisy particle aggregation in which cell shape is a key determining factor.
description: 9 pages, 11 figures, 2 supplementary videos (on Youtube), submitted to Computational Particle Mechanics, special issue: Jos\'e-Manuel Garcia Aznar (Ed.) Particle-based simulations on cell and biomolecular mechanics
Additional file 7 of Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought
Creators: name: Ebeed, Heba Talat
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 7: Table S6. Distribution of Cis-elements of the promoter regions of PAs biosynthesis genes in wheat.
On Beurling's uncertainty principle
Creators: name: Gao, Xin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: We generalise a result of Hedenmalm to show that if a function $f$ on $\mathbb{R}$ is such that $\int_{\mathbb{R}^2} \bigl|f(x) \, \hat f(y)\bigr| \,e^{λ\left|xy\right|} \,dx\,dy = O( (1-λ)^{-N} )$ as $λ\to 1-$, then $f$ is the product of a polynomial and a gaussian.
A stochastic quasi-classical wavefunction of the Universe from the third quantization procedure
Creators: name: Ivanov, P.
name: Chernov, S. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: (abbreviated) We study quantized solutions of WdW equation describing a closed FRW universe with a $Λ$ term and a set of massless scalar fields. We show that when $Λ\ll 1$ in the natural units and the standard $in$-vacuum state is considered, either wavefunction of the universe, $Ψ$, or its derivative with respect to the scale factor, $a$, behave as random quasi-classical fields at sufficiently large values of $a$, when $1 \ll a \ll e^{2\over 3Λ}$ or $a \gg e^{2\over 3Λ}$, respectively. Statistical r.m.s value of the wavefunction is proportional to the Hartle-Hawking wavefunction for a closed universe with a $Λ$ term. Alternatively, the behaviour of our system at large values of $a$ can be described in terms of a density matrix corresponding to a mixed state, which is directly determined by statistical properties of $Ψ$. It gives a non-trivial probability distribution over field velocities. We suppose that a similar behaviour of $Ψ$ can be found in all models exhibiting copious production of excitations with respect to $out$-vacuum state associated with classical trajectories at large values of $a$. Thus, the third quantization procedure may provide a 'boundary condition' for classical solutions of WdW equation.
description: To be published in PRD, several misprints have been corrected and a reference has been added
Prenatal orientation to the cardiac NICU
Creators: name: Auricchio, Elizabeth
Publisher: name: No Publisher Supplied
Year: 2022

description: Purpose of Project: A congenital heart defect (CHD) diagnosis often increases maternal stress during and after a pregnancy. High levels of stress and anxiety can have harmful effects on the fetus and newborn. Current evidence recommends continuous prenatal counseling to ease maternal stress through education, preparation, and emotional support. This quality improvement project aimed to improve maternal stress levels with a prenatal orientation to the cardiac NICU. Methodology: This project used a qualitative approach to implement a prenatal orientation to the Cardiac NICU with a pre and post survey to assess influence on perceived stress scale (PSS) scores. All English and Spanish speaking mothers 18 years and older who presented to the hospital’s fetal cardiology clinic was offered to participate in the study. Results: A total of six participants were included in the analysis of pre and post survey findings. Most likely attributable to a type II error in sample size, a statistically insignificant change in PSS scores was found (z = -1.826, p = 0.068). However, stress levels decreased altogether after the intervention. The average pre-survey PSS score was within the moderate stress level (M = 16.8, SD = 2.387), with a 95% CI [13.84, 19.76]. Comparatively, the average post-survey PSS score was within the low stress category (M = 11.2, SD = 6.058), with a 95% CI [3.68, 18.72]. Implications for Practice: An orientation to the cardiac NICU is an integral component of prenatal care for mothers with a fetal CHD diagnosis. This resource can reduce stress levels at a vulnerable time to the health of both mother and baby. Standardizing this type of prenatal support can contribute to the improvement of maternal and infant health.
Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?
Creators: name: Bergen, Phillip J.
name: Nation, Roger L.
name: Forrest, Alan
name: Velkov, Tony
name: Tsuji, Brian T.
name: Tran, Thien B.
name: Li, Jian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The polymyxin antibiotics [colistin and polymyxin B (PMB)] are increasingly used as a last-line option for the treatment of infections caused by extensively drug-resistant Gram-negative bacteria. Despite having similar structures and antibacterial activity in vitro, the two clinically available polymyxins have very different pharmacological properties, as colistin (polymyxin E) is intravenously administered to patients in the form of an inactive prodrug colistin methanesulphonate (sodium). This review will discuss recent progress in the pharmacokinetics/pharmacodynamics and toxicity of colistin and PMB, the factors that affect their pharmacological profiles, and the challenges for the effective use of both polymyxins. Strategies are proposed for optimising their clinical utility based upon the recent pharmacological studies in vitro, in animals and patients. In the ‘bad bugs, no drugs’ era, polymyxins are a critically important component of the antibiotic armamentarium against difficult-to-treat Gram-negative ‘superbugs’. Rational approaches to the use of polymyxins must be pursued to increase their effectiveness and to minimise resistance and toxicity.
RF Lens-Embedded Massive MIMO Systems: Fabrication Issues and Codebook Design
Creators: name: Kwon, Taehoon
name: Lim, Yeon-Geun
name: Min, Byung-Wook
name: Chae, Chan-Byoung
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we investigate a radio frequency (RF) lens-embedded massive multiple-input multiple-output (MIMO) system and evaluate the system performance of limited feedback by utilizing a technique for generating a suitable codebook for the system. We fabricate an RF lens that operates on a 77 GHz (mmWave) band. Experimental results show a proper value of amplitude gain and an appropriate focusing property. In addition, using a simple numerical technique--beam propagation method (BPM)--we estimate the power profile of the RF lens and verify its accordance with experimental results. We also design a codebook--multi-variance codebook quantization (MVCQ)--for limited feedback by considering the characteristics of the RF lens antenna for massive MIMO systems. Numerical results confirm that the proposed system shows significant performance enhancement over a conventional massive MIMO system without an RF lens.
Stick-slip instabilities in sheared granular flow: the role of friction and acoustic vibrations
Creators: name: Lieou, Charles K. C.
name: Elbanna, Ahmed E.
name: Langer, J. S.
name: Carlson, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: We propose a theory of shear flow in dense granular materials. A key ingredient of the theory is an effective temperature that determines how the material responds to external driving forces such as shear stresses and vibrations. We show that, within our model, friction between grains produces stick-slip behavior at intermediate shear rates, even if the material is rate-strengthening at larger rates. In addition, externally generated acoustic vibrations alter the stick-slip amplitude, or suppress stick-slip altogether, depending on the pressure and shear rate. We construct a phase diagram that indicates the parameter regimes for which stick-slip occurs in the presence and absence of acoustic vibrations of a fixed amplitude and frequency. These results connect the microscopic physics to macroscopic dynamics, and thus produce useful information about a variety of granular phenomena including rupture and slip along earthquake faults, the remote triggering of instabilities, and the control of friction in material processing.
description: 12 pages, 8 figures
Effect of maternal-infant attitude on breastfeeding exclusivity and duration
Creators: name: Coy, Shanice
Publisher: name: No Publisher Supplied
Year: 2022

description: Purpose of Project: The purpose of this project was to support the idea that prenatal breastfeeding classes help improve overall breastfeeding rates. The Iowa Infant Feeding Attitude Scale was used to assess maternal attitudes toward breastfeeding. Methodology: The project took place at a women’s health clinic associated with a 554-bed hospital in northern New Jersey, who mainly serve an underserved population. Prospective chart reviews and recruitment were done over a two-week timeframe. The Iowa Infant Feeding Attitude Scale was administered when a patient signed up for an educational breastfeeding class and again one week after delivery. Results: A total of four patients showed interest in participating in the study. Three patients signed consents and completed the pre-survey. Two patients attended an online one-hour educational breastfeeding class. Those two patients were contacted one week after delivery to assess for breastfeeding exclusivity and plans for breastfeeding duration. The patients completed the post-test during that time of contact. Those who participated in the study were Hispanic, between the ages of 20 and 29, and had gestational ages of 37 weeks and 38 weeks. Both women indicated it was their first child, and both were on disability leave at time of recruitment. When initially asked about plans for feeding their baby, participant A stated she wanted to exclusively breastfeed, and participant B mentioned she wanted to breastfeed and bottle-feed. Both women had no breastfeeding experience and were both enrolled in WIC. Participant A had a slight increase in scores between the pre- and post-intervention IIFAS. Participant B’s scores remained the same. Since the number of participants recruited for this project was less than anticipated and did not allow for a pre- and post-intervention analysis, more information is needed to assess the benefits of online educational breastfeeding group sessions. Implications for Practice: Both peer support and breastfeeding classes can be provided virtually or in-person to help increase breastfeeding initiation, duration, and exclusivity by increasing maternal attitudes towards breastfeeding. Providing support to underserved populations including the Hispanic and African American populations can lead to major changes in practice and help increase the health of these populations. Accordingly, a reduced risk of long-term medical conditions is associated with an overall improved cost effectiveness. Moreover, an increase in breastfeeding can increase bonding between mother and child.
Legacy Media Coverage of Russia’s Activities in the Arctic
Creators: name: Morris, Saga Helgason
Publisher: name: Stanford Digital Repository
Year: 2022
Subjects: subject: Arctic Regions
subject: Geopolitics
subject: Russia
subject: Militarization
subject: Journalists
subject: Press coverage
subject: Reporters and reporting
subject: Mass media--Political aspects
subject: Climatic changes--Government policy
subject: Climatic changes--Political aspects

description: The changing conditions in the Arctic have sparked interest for stakeholders across the globe. The melting ice sheets create both opportunities and challenges. New transport routes are opening up that would shorten delivery times to both Europe and Asia significantly. Oil and gas exploration is of interest to many. Warmer temperatures threaten biodiversity and the communities dependent thereupon. Geopolitical and security issues are of concern and actors such as China and the EU are vying for position. With the largest Arctic coastline of all the Arctic states, Russia has by far the most dominating presence in the region. 
For decades, Russia’s motivations, both generally and in the Arctic, have been an enigma for Western audiences to decipher, which leaves room for various interpretations and the potential for misunderstanding. The media plays a significant role when it comes to informing the public by drawing insights from current developments. The media has the power to shape and influence the public’s opinion, whether rightly or wrongly. 
This study incorporates a content analysis of legacy news media outlets from a multi-national perspective. Key themes and narratives from the US, Germany, Norway and Iceland are evaluated and compared as these states all have a claim in the Arctic and yet have a unique relationship with Russia.  
From a multi-national perspective, the media coverage in this study has revealed the Arctic’s distinctive duality of cooperation and tension. The coverage, as expected, reflects the differing national stances towards Russia whereby the distinctive interests of each state are seen in the reporting. These discrepancies are indicative of the respective government’s commitment to and policy in the region in the future. As we have witnessed in the wake of Russia’s invasion into Ukraine, each state’s relationship with Russia and the subsequent reporting of relations can and will change in accordance with world events. Such changes in dynamics provide ample material for a future study.
The small and the beautiful: How the star formation law affects galactic disk structure
Creators: name: Braun, Harald
name: Schmidt, Wolfram
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the influence of different analytical parameterizations and fit functions for the local star formation rate in AMR simulations of an isolated disk galaxy with the Nyx code. Such parameterizations express the star formation efficiency as function of the local turbulent Mach number and virial parameter. By employing the method of adaptively refined large eddy simulations, we are able to evaluate these physical parameters from the numerically unresolved turbulent energy associated with the grid scale. We consider both single and multi free-fall variants of star formation laws proposed by Padoan & Nordlund, Hennebelle & Chabrier, and Krumholz & McKee, summarised and tested recently with numerical simulations by Federrath & Klessen. We find that the global star formation rate and the relation between the local star formation rate and the gas column density is reproduced in agreement with observational constraints by all multi free-fall models of star formation. Some models with obsolete calibration or a single free-fall time scale, however, result in an overly clumpy disk that does not resemble the structure of observed spirals.
description: 12 pages, 6 figures, accepted by MNRAS
Discriminative Predicate Path Mining for Fact Checking in Knowledge Graphs
Creators: name: Shi, Baoxu
name: Weninger, Tim
Publisher: name: arXiv
Year: 2015
Subjects: subject: Databases (cs.DB)
subject: Artificial Intelligence (cs.AI)
subject: Information Retrieval (cs.IR)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences
subject: H.4, H.2.8

description: Traditional fact checking by experts and analysts cannot keep pace with the volume of newly created information. It is important and necessary, therefore, to enhance our ability to computationally determine whether some statement of fact is true or false. We view this problem as a link-prediction task in a knowledge graph, and present a discriminative path-based method for fact checking in knowledge graphs that incorporates connectivity, type information, and predicate interactions. Given a statement S of the form (subject, predicate, object), for example, (Chicago, capitalOf, Illinois), our approach mines discriminative paths that alternatively define the generalized statement (U.S. city, predicate, U.S. state) and uses the mined rules to evaluate the veracity of statement S. We evaluate our approach by examining thousands of claims related to history, geography, biology, and politics using a public, million node knowledge graph extracted from Wikipedia and PubMedDB. Not only does our approach significantly outperform related models, we also find that the discriminative predicate path model is easily interpretable and provides sensible reasons for the final determination.
description: 17 pages, 4 Figures. To Appear in Knowledge Based Systems