cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Engineer's Recommendation For Full-Time, On-Site Project Representative -- NSPE Case No. 84-5
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Ethics and Society
Public Health and Safety
Research and Practice
Risk
Safety

description: An engineer is concerned for worker safety during construction but yields to his client's objections to the cost of an on-site representative. This is a historical case reviewed by the NSPE Board of Ethical Review in 1984.
Exotic quantum holonomy and higher-order exceptional points in quantum kicked tops
Creators: name: Tanaka, Atushi
name: Kim, Sang Wook
name: Cheon, Taksu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The correspondence between exotic quantum holonomy that occurs in families of Hermitian cycles, and exceptional points (EPs) for non-Hermitian quantum theory is examined in quantum kicked tops. Under a suitable condition, an explicit expressions of the adiabatic parameter dependencies of quasienergies and stationary states, which exhibit anholonomies, are obtained. It is also shown that the quantum kicked tops with the complexified adiabatic parameter have a higher order EP, which is broken into lower order EPs with the application of small perturbations. The stability of exotic holonomy against such bifurcation is demonstrated.
description: 9 pages, 6 figures. Improved explanations and added references (v2). Fixed typo (v3)
Improving the geographic distribution of doctors: an investigation of early career rural and remote practice and associated factors in Indonesia
Creators: name: Putri, Likke Prawidya
Publisher: name: Monash University
Year: 2023
Subjects: Primary health care
Public health not elsewhere classified
Health policy

description: Doctor shortage is one of the causes of poorer health among rural and remote populations compared to their urban counterparts. Exploring the correlates of rural practice could help inform strategies to increase rural and remote doctor supply. I conducted a cross-sectional national survey of early-career doctors in Indonesia, collecting data on their locations from childhood to current employment, and a range of other characteristics, to determine factors associated with rural practice. I found that rural practice is strongly correlated with previous rural exposures, and conclude that increasing the medical workforce in rural and remote areas requires a continuum of strategies. These could include selecting medical students with rural origins, rural exposure and content during medical training, and supporting particular needs by gender and family circumstances.
CULTURAL HERITAGE ADAPTIVE REUSE: LEARNING FROM SUCCESS AND FAILURE STORIES IN THE CITY OF SALERNO, ITALY
Creators: name: Lupacchini, Raffaele
name: Gravagnuolo, Antonia
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: Cultural heritage is considered as a resource for sustainable development in cities and regions. Local governments such as municipalities and provincial bodies are often owners of cultural heritage assets that are not listed as national or World Heritage properties, but are recognized as relevant cultural heritage for the local communities. However, they lack the necessary financial and human resources to recover and maintain this “minor” cultural heritage. Thus, decisions on the financing and management of cultural heritage owned by local governments highly depend on the availability of the public owner to create partnerships with third parties. This paper analyses and compares success and failure cases in cultural heritage adaptive reuse in the city of Salerno, Italy, in order to identify decision-making criteria for public owners of “minor” cultural heritage assets based on the characteristics of different heritage properties and context conditions. Keywords: cultural heritage, adaptive reuse, management models
description: Bulletin of the Calza Bini Center, V. 19 N. 2 (2019): New Green Deal: Towards Ecological and Human-centered Urban Development Strategies
title: Microengineering Approaches for Regenerative Medicine
Creators: name: Sun, Yubing
Publisher: name: eScholarship@UMMS
Year: 2016

description: Stem cells, especially human pluripotent stem cells (hPSCs), hold significant promise for modeling developmental and disease processes, drug and toxicology screening, and cell-based regenerative medicine. Most hPSC studies have so far focused on identifying extrinsic soluble factors, intracellular signaling pathways, and transcriptional regulatory networks involved in regulating hPSC behaviors. We focus on the development and applications of some novel synthetic micromechanical systems to understand the mechano-sensitive and -responsive properties of hPSCs and their functional regulation of self-renewal, directed differentiation, and survival of hPSCs. First, we have demonstrated that rigid PDMS micropost arrays (PMAs) support the maintenance of pluripotency of hPSCs. Blocking cytoskeleton contractility by blebbistatin and inhibiting E-cadherin functions by DECMA-1 antibody both impair mechanoresponsive self-renewal of hPSCs on rigid substrates. We have further achieved efficient neuroepithelial induction, caudalization, and motor neuron differentiation from hPSCs combining soft PMAs (Eeff < 5kPa) with dual Smad inhibition. The purity and yield of functional motor neurons derived from hPSCs within 23 days of culture using soft PMAs were improved four- and twelve-fold, respectively, compared to coverslips or rigid PMAs. Our mechanistic work has helped reveal for the first time that biomechanical cues, including intracellular contractile forces and cell shape, converge and reinforce signal integration of TGF-β, Wnt, Hippo/YAP, Rho GTPase, and the actomyosin cytoskeleton to regulate the neural plate specification. We also developed a novel acoustic tweezing cytometry (ATC) utilizing ultrasound pulses to actuate functionalized lipid-encapsulated microbubbles (MBs) targeted to cell surface integrin receptors to exert subcellular mechanical forces in the pN - nN range. ATC can robustly induce cell traction force changes through acoustic radiation forces and bubble cavitation induced shear stresses. Importantly, ATC stimulations increased the survival rate and cloning efficiency of hESCs by 3-fold, suggesting its potential application in large-scale expansion of hPSCs.
title: Multiple Chronic Conditions and Psychosocial Limitations in a Contemporary Cohort of Patients Hospitalized with an Acute Coronary Syndrome
Creators: name: Tisminetsky, Mayra
name: Gurwitz, Jerry H.
name: McManus, David D.
name: Saczynski, Jane S.
name: Waring, Molly E.
name: Erskine, Nathaniel
name: Anatchkova, Milena D.
name: Parish, David C.
name: Lessard, Darleen M.
name: Kiefe, Catarina I.
name: Goldberg, Robert J.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Background: As adults live longer, multiple chronic conditions have become more prevalent over the past several decades. We describe the prevalence of, and patient characteristics associated with, cardiac and non-cardiac-related multimorbidities in patients discharged from the hospital after an acute coronary syndrome (ACS).

Methods: We studied 2,174 patients discharged from the hospital after an ACS at 6 medical centers in Massachusetts and Georgia between April, 2011 and May, 2013. Hospital medical records yielded clinical information including presence of 8 cardiac-related and 8 non-cardiac-related morbidities on admission. We assessed multiple psychosocial characteristics during the index hospitalization using standardized in-person instruments.

Results: The mean age of the study sample was 61 years, 67% were men, and 81% were non-Hispanic whites. The most common cardiac-related morbidities were hypertension, hyperlipidemia, and diabetes (76%, 69%, and 31%, respectively). Arthritis, chronic pulmonary disease, and depression (20%, 18%, and 13%, respectively) were the most common non-cardiac morbidities. Patients with ≥4 morbidities (37% of the population) were slightly older and more frequently female than those with 0-1 morbidity; they were also heavier and more likely to be cognitively impaired (26% vs. 12%), have symptoms of moderate/severe depression (31% vs. 15%), high perceived stress (48% vs. 32%), a limited social network (22% vs. 15%), low health literacy (42% vs. 31%), and low health numeracy (54% vs. 42%).

Conclusions: Multimorbidity, highly prevalent in patients hospitalized with an ACS, is strongly associated with indices of psychosocial deprivation. This emphasizes the challenge of caring for these patients, which extends well beyond ACS management.
DA WASTESCAPE A RISORSA: APPROCCI MULTIMETODOLOGICI PER LA RIGENERAZIONE DEI PAESAGGI DI SCARTO
Creators: name: Cerreta, Maria
name: De Rosa, Fortuna
name: De Toro, Pasquale
name: Inglese, Pasquale
name: Iodice, Silvia
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: L’attivazione di un processo di gestione, recupero, rigenerazione e riciclo dei paesaggi di scarto, definiti “wastescape”, costituisce la sfida affrontata nell’ambito del Progetto Horizon 2020 “REsource Management in Peri-urban Areas: Going Beyond Urban Metabolism” (REPAiR). Secondo i principi dell’Economia Circolare, i wastescape possono essere considerati una risorsa innovativa per la rigenerazione dei territori in crisi, consentendo un cambio di paradigma in grado di determinare molteplici e differenti implicazioni ambientali, economiche, sociali e culturali. Esplorare approcci e tecniche sinergiche per affrontare e gestire il cambiamento implica anche considerare i rifiuti che caratterizzano i wastescape, in particolare i rifiuti derivanti dall’attività edilizia, come uno strumento per attivare nuovi modelli di utilizzo sostenibile e circolare delle risorse territoriali e individuare strategie di sviluppo integrate, eco-innovative e “place-based”. Parole chiave: Economia Circolare, Metabolismo Urbano, Wastescapes
description: BDC. Bollettino Del Centro Calza Bini, V. 19 N. 2 (2019): New Green Deal: Towards Ecological and Human-centered Urban Development Strategies
title: Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease
Creators: name: Tisminetsky, Mayra
name: Goldberg, Robert J.
name: Gurwitz, Jerry H.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Objective: To synthesize the current literature on the magnitude and impact of multiple chronic conditions on clinical outcomes, including total in-hospital and post discharge mortality and hospitalizations, in older patients with cardiovascular disease (CVD).

Methods: A systematic review was conducted. Four electronic databases and article bibliographies were searched for publications from 2005 to 2015 which assessed the impact of multimorbidity on clinical outcomes in the elderly with CVD. Identified studies were screened using pre-defined criteria for eligibility.

Results: Fifteen studies met our inclusion criteria. Multimorbidity was assessed by simple counting of morbidities and by the Charlson and Elixhauser indices. Case-fatality rates ranged from between 13% and 21% for patients with a myocardial infarction. Long-term mortality ranged from 28% to 73% among patients with heart failure, and 24% of patients with heart failure and presenting multimorbidities had at least one readmission during a follow-up period of 17 months. Most of the studies reported a significant association between number of multimorbidities or particular morbidities and the risk of dying, the most frequent morbidities examined were diabetes, chronic kidney disease, anemia, chronic pulmonary disease and dementia/cognitive impairment

Conclusions: There are limited data on the magnitude and impact of multimorbidities on clinical outcomes, and even less data on patient centered outcomes among elderly patients with CVD. There are also inconsistencies in the manner by which multimorbidities are assessed; very few studies have approached the “real” complexity of patients with CVD and multimorbidities and how best to manage these high risk patients.
IL MODELLO DI CITTA’ CIRCOLARE COME MODELLO DI SVILUPPO PER LE CITTA’ DI PICCOLA, MEDIA E GRANDE DIMENSIONE
Creators: name: Fusco Girard, Luigi
name: Nocca, Francesca
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Come risposta alle sfide legate ai cambiamenti climatici, al degrado ambientale e alla crisi sociale ed economica, l’Europa ha approvato una serie di documenti e misure per promuovere un’Europa “più verde” e, allo stesso tempo, “più sociale”. I due concetti sono affrontati in documenti strategici distinti, inducendo a pensare alla necessità di un trade-off tra crescita economica, sociale e “verde”. Il modello dell’economia circolare può contribuire a ridurre questo trade-off. Nel presente contributo si vuole mettere in evidenza come il modello dell’economia circolare può rappresentare un modello di sviluppo per le grandi città, ma anche per le città di piccole e medie dimensioni, per diventare “città circolari”. La prospettiva del paesaggio è qui proposta come approccio che orienta possibili soluzioni per lo sviluppo della città circolare. Concentrando l’attenzione sul contesto italiano, è analizzata la città metropolitana di Napoli e il ruolo che alcuni fattori possono rivestire nella sua transizione verso il modello di città circolare. Parole chiave: città metropolitana circolare; Historic Urban Landscape; strumenti di valutazione ibridi
description: BDC. Bollettino Del Centro Calza Bini, V. 19 N. 2 (2019): New Green Deal: Towards Ecological and Human-centered Urban Development Strategies
Hermite multiplier sequences and their associated operators
Creators: name: Forgács, Tamás
name: Piotrowski, Andrzej
Publisher: name: arXiv
Year: 2013
Subjects: subject: Complex Variables (math.CV)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 30C15, 26C10

description: We provide an explicit formula for the coefficient polynomials of a Hermite diagonal differential operator. The analysis of the zeros of these coefficient polynomials yields the characterization of generalized Hermite multiplier sequences which arise as Taylor coefficients of real entire functions with finitely many zeros. We extend our result to functions in $\mathcal{L-P}$ with infinitely many zeros, under additional hypotheses.
TOWARDS A CIRCULAR GOVERNANCE FOR THE ADAPTIVE REUSE OF CULTURAL HERITAGE
Creators: name: Bosone, Martina
name: Micheletti, Serena
name: Gravagnuolo, Antonia
name: Garzillo, Cristina
name: Wildman, Allison
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: The adaptive reuse of abandoned cultural heritage assets can be seen as a regenerative process, which turns “wastescapes” into attractive places. Processes of urban transformation implemented by citizens represent cultural practices in which individuals are producers, and not only consumers, of cultural meanings. The renewed relationship between people and places through coordinated collective action becomes particularly relevant in the adaptive reuse of cultural heritage. This paper aims to investigate how “circular governance” can be interpreted and implemented in urban regeneration strategies aimed at “human-centred” circular development. Through case studies examples, the role of citizens-led initiatives in cultural heritage adaptive reuse is explored to identify common elements useful to draft a definition of circular governance and provide guidelines for policy makers. Keywords: common goods, circular governance, Cultural heritage adaptive reuse
description: Bulletin of the Calza Bini Center, V. 19 N. 2 (2019): New Green Deal: Towards Ecological and Human-centered Urban Development Strategies
IMPLEMENTING THE CIRCULAR ECONOMY: THE ROLE OF CULTURAL HERITAGE AS THE ENTRY POINT. WHICH EVALUATION APPROACHES?
Creators: name: Fusco Girard, Luigi
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: The adaptive re-use of cultural assets is proposed as the entry point for implementing the circular city, that is the specific spatial/territorial aspect of the circular economy. The circular re-use contributes to implement the “city of the human being and of nature”, in which the nature is considered the most important infrastructure. The paper discuss the ways in which adaptive reuse can be implemented, starting from some fundamental problems and the approach taken, and that determines the differences with other approaches about heritage assets reuse, in which the key attention is about the attractiveness and its multidimensional impacts and in which the economic, environmental, social, cultural dimensions are interpreted as having the same weight. The perspective is to search in the adaptive reuse new solutions able to re-integrate economy into ecology and into the human paradigm using new tools: from new management models to new evaluation decision support systems. Keywords: adaptive reuse; integrated evaluation; circular economy
description: Bulletin of the Calza Bini Center, V. 19 N. 2 (2019): New Green Deal: Towards Ecological and Human-centered Urban Development Strategies
Review of single vector boson production in pp collisions at $\sqrt{s} = 7$ TeV
Creators: name: Schott, Matthias
name: Dunford, Monica
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: This review summarises the main results on the production of single vector bosons in the Standard Model, both inclusively and in association with light and heavy flavour jets, at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of 7 TeV. The general purpose detectors at this collider, ATLAS and CMS, each recorded an integrated luminosity of $\approx 40\,{\rm pb^{-1}}$ and $5\,{\rm fb^{-1}}$ in the years 2010 and 2011, respectively. The corresponding data offer the unique possibility to precisely study the properties of the production of heavy vector bosons in a new energy regime. The accurate understanding of the Standard Model is not only crucial for searches of unknown particles and phenomena but also to test predictions of perturbative Quantum-Chromo-Dynamics calculations and for precision measurements of observables in the electroweak sector. Results from a variety of measurements in which single W or Z bosons are identified are reviewed. Special emphasis in this review is given to interpretations of the experimental results in the context of state-of-the-art predictions.
description: 60 pages, 64 figures, For Eur. Phys. J. C
Editoriale
Creators: name: Fusco Girard, Luigi
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Si stanno moltiplicando le riflessioni sulla nostra epoca definita come Antropocene (Crutzen e Brauch, 2016; Bonneuil e Fressoz, 2016; Steffen et al., 2007) alla luce della rilevante accelerazione di molti impatti conseguenti alle varie azioni umane sull’ambiente, a cominciare dalla concentrazione di CO2 in atmosfera. In effetti, le conseguenze delle attività umane stanno mettendo in crisi il funzionamento dell’ecosistema Terra, come risulta bene evidente dai vari Rapporti dell’IPCC (IPCC 2018; 2019). Il cambiamento climatico si configura come la grande questione del XXI secolo. Occorre moltiplicare gli investimenti nella ricerca: sul rapporto tra cambiamenti climatici e i diversi impatti conseguenti, che vanno dal degrado ambientale alle conseguenze sull’economia, sulla salute della società, sull’urbanistica ecc. Occorre che le Università promuovano l’insegnamento e la ricerca sul cambiamento climatico, sugli impatti che esso arreca a cominciare da quelli sulla salute delle persone, dell’ecosistema naturale e dell’economia. È infatti in gioco il futuro della nostra casa comune, della nostra Terra. Occorre uno specifico Piano Strategico di Ricerca su quanto sopra per mettere a fuoco con chiarezza le interdipendenze tra cambiamento climatico e salute/benessere, economia, industria, agricoltura, urbanistica, energia, cercando di identificare nuovi modelli di sviluppo economico/territoriale, nuovi modelli di produzione e distribuzione della ricchezza. La “Terza Missione” non riguarda solo il trasferimento tecnologico e l’imprenditorialità, ma anche la promozione di un modello desiderabile di economia e di città. La sfida non è solo tecnico/tecnologica ma anche culturale/umanistica. Non c’è infatti una cultura appropriata alle grandi sfide del nostro tempo. Occorre modificare le scelte grandi e piccole, in un contesto storico sempre più complesso e contradditorio, con un tempo sempre più ridotto per poter scegliere e con una posta in gioco sempre più alta.
description: BDC. Bollettino Del Centro Calza Bini, V. 19 N. 2 (2019): New Green Deal: Towards Ecological and Human-centered Urban Development Strategies
title: Role of TSH and excess Heart Age in Predicting Atrial Fibrillation Recurrence Post-Ablation
Creators: name: Vaze, Aditya
name: Ogunsua, Adedotun
name: Pach, Jakub
name: McManus, David D.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Background: The association between atrial fibrillation (AF) and thyroid disease as defined by thyroid stimulating hormone (TSH) is established in literature. However, the relationship between TSH and recurrence of AF post ablation has not been established.

Methods: We studied 207 patients (60.54±9.39yrs, 35.7% female) with persistent or paroxysmal AF who underwent either Cryo or RFA ablation between April 2011 and Jan 2015 at our center. Patients were stratified into hypothyroid (TSH > >4.5 U/mL), euthyroid (TSH 0.5-4.5 U/mL) and hyperthyroid (TSH < 0.5 U/mL) based on pre procedure testing. Heart age was computed based on Framingham risk factors. Excess heart age was defined as the difference between actual age and heart age. Logistic regression and cox-proportional hazards model were implemented using R statistical software (v3.2.0).

Results: There was a statistically significant lower rate of AF recurrence among male patients (OR 2.92, p=0.003). In univariate analysis, there was no statistically significant relationship between TSH and incidence of AF recurrence (OR 1.05, p=0.74). Cox proportional hazards models did not show an association between recurrence and TSH states (HR 0.85, p=0.74 for hypothyroid and HR 0.75, p=0.56 for hyperthyroid).

Conclusions: This exploratory showed that TSH may not play a role in AF recurrence. While there is a tendency towards an association between TSH and AF recurrence, this was not statistically significant. We hypothesize that overt hyperthyroidism prior to ablation will not increase chance of recurrence. This was true after adjustment for Framingham risk factors. The limitation of this study was the small sample size of the patients with TSH in the hyperthyroid range. Further analysis using larger dataset is indicated.
การประเมินหลังการใช้งานภายในอาคารปฏิบัติธรรม วัดมัชฌันติการาม กรุงเทพมหานคร
Creators: name: สุพัตรา ซ้วนลิ่ม
Publisher: name: คณะสถาปัตยกรรมศาสตร์
Year: 2023
Subjects: การประเมินหลังการใช้งาน
อาคารปฏิบัติธรรม
วัดมัชฌันติการาม

description: วารสาร สิ่งแวดล้อมสรรค์สร้างวินิจฉัย (Built Environment Inquiry BEI), 22, 1, 18-33
Complimentary Seminar Registration -- NSPE Case No. 87-5
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Bribery and Extortion
Conflict of Interest
Ethics and Society
Research and Practice
Social Responsibility
Workplace Ethics

description: A pipe company invites engineers to a complimentary educational seminar on the use of its products. This could be compared to perks and gifts given to physicians by drug companies.
Atomistic origins of high-performance in hybrid halide perovskite solar cells
Creators: name: Frost, Jarvist M.
name: Butler, Keith T.
name: Brivio, Federico
name: Hendon, Christopher H.
name: van Schilfgaarde, Mark
name: Walsh, Aron
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The performance of organometallic perovskite solar cells has rapidly surpassed that of both conventional dye-sensitised and organic photovoltaics. High power conversion efficiency can be realised in both mesoporous and thin-film device architectures. We address the origin of this success in the context of the materials chemistry and physics of the bulk perovskite as described by electronic structure calculations. In addition to the basic optoelectronic properties essential for an efficient photovoltaic device (spectrally suitable band gap, high optical absorption, low carrier effective masses), the materials are structurally and compositionally flexible. As we show, hybrid perovskites exhibit spontaneous electric polarisation; we also suggest ways in which this can be tuned through judicious choice of the organic cation. The presence of ferroelectric domains will result in internal junctions that may aid separation of photoexcited electron and hole pairs, and reduction of recombination through segregation of charge carriers. The combination of high dielectric constant and low effective mass promotes both Wannier-Mott exciton separation and effective ionisation of donor and acceptor defects. The photoferroic effect could be exploited in nanostructured films to generate a higher open circuit voltage and may contribute to the current-voltage hysteresis observed in perovskite solar cells.
description: 6 pages, 5 figures
title: Triad of Suffering:  Pain, Depression, and Anxiety among Newly Admitted Nursing Homes Residents
Creators: name: Ulbricht, Christine M.
name: Hunnicutt, Jacob N.
name: Lapane, Kate L.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Introduction: Depression and anxiety disorders are prevalent among older adults, as is pain. These conditions are independently associated with reduced functioning and quality of life. Despite the frequent co-occurrence of all three of these disorders, little is known about the epidemiology and treatment of these disorders in nursing homes. The objectives of this study were to: 1) describe the prevalence of depression, anxiety disorders, and pain among newly admitted nursing home residents; and 2) describe the treatment of these disorders.

Methods: We used national Minimum Data Set (MDS) version 3.0 data from 2011-2012. Federally-mandated for all residents living in Medicare/Medicaid-certified nursing facilities, the MDS is a comprehensive clinical assessment including > 400 items on sociodemographics, mood and behavior, symptoms, pain, clinical diagnoses, and treatments. We identified residents with MDS assessments performed at admission between 2011-2012 who were 65 years of age or older; were non-comatose; were not admitted to a swing bed provider; did not have mental retardation or developmental delays; & were able to complete a pain assessment (n = 783,826).

Results: At admission, 36% of residents (n = 283,050) had a documented active diagnosis of depression (other than bipolar disorder), anxiety disorder, or both. Having pain in the last 5 days was reported by 53% of residents. Rates of self-reported pain were similar across psychiatric disorders. 60-62% of residents reporting pain received a combination of pain management interventions. More than a third of residents did not receive any psychiatric treatment.

Conclusions: Many nursing home residents experience pain, depression, and anxiety at admission. Pain management is common. An improved understanding of the relationships between pain, mental health, and analgesic use is necessary since older adults, particularly those in nursing homes, are routinely excluded from clinical trials despite being at high risk for adverse effects of analgesics and other treatments.
Depletion interaction between two ellipsoids
Creators: name: Miao, Han
name: Li, Yao
name: Ma, Hongru
Publisher: name: arXiv
Year: 2013
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The depletion interactions between two ellipsoids in three configurations were studied by both Monte Carlo simulation with the Wang-Landau algorithm and the density functional theory in the curvature expansion approximation. Common features of the depletion interactions were found and the results were as expected. By comparing the results of the two methods, it is concluded that density functional theory under the curvature expansion approximation gave very good results to the depletion forces.
A Model of BPS Black Holes in a Discrete Space
Creators: name: Kan, Nahomi
name: Kobayashi, Koichiro
name: Shiraishi, Kiyoshi
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We examine a model of BPS black holes lying on a discrete extra space. The geometry is obtained from the discretization of the harmonic equation. We study the scattering amplitudes of two types of scalar fields, which correspond to fields in a bulk and on a brane. We conclude that the two types of scattering can be distinguished in the region of large transfer momentum.
description: 14 pages, 9 figures, a few typo fixed
title: Sulforaphane Treatment of Children with Autism Spectrum Disorder
Creators: name: Diggins, Eileen
name: Zimmerman, Andrew
name: Singh, Kanwaljit
name: Connors, Susan
Publisher: name: eScholarship@UMMS
Year: 2016

description: Abstract: This clinical trial in autism spectrum disorder (ASD) tests a nontoxic approach to therapy of ASD.

Background: Direct treatment of underlying mechanisms in ASD is limited. Cellular dysfunction in ASD may involve a number of related metabolic pathways. A clinical clue may be found in the “fever effect” in ASD, in which febrile illness dramatically but temporarily ameliorates disordered behavior. Fever stimulates heat shock proteins (HSP) and cellular stress responses that may ultimately lead to improved synaptic function and increased long-range connectivity. The expression of gene transcription by NFE2L2 (Nrf2), which is reduced in ASD, may also increase during fever. Sulforaphane (SF), an isothiocyanate obtained from 3-day-old broccoli sprouts, induces HSP and Nrf2 as well as “cell-protective” responses. SF has several possible modes of action that may benefit ASD through common cellular mechanisms underlying heterogeneous phenotypes. SF crosses the blood brain barrier and is bioavailable orally.

Preliminary data: In a randomized, double-blind, placebo-controlled pilot trial in 44 male adolescents and adults (13-30 years), results showed SF was well tolerated without significant side effects. On average, participants on SF (particularly those with a history of fever effect) showed significantly more improvements in ASD symptoms than placebo participants. Significant improvements for SF participants included social interaction, aberrant/abnormal behavior, repetitive/stereotypical behavior, and verbal communication.

Current study: Our randomized, double-blind, placebo-controlled phase-2 clinical trial at UMass has three aims: To determine: (1) if orally administered SF has measurable effects in children (ages 3-12 years) with ASD; (2) if treatment with sulforaphane is safe and well tolerated; (3) To elucidate cellular biomarkers that support the mechanisms of action of SF in ASD. We hypothesize that SF will have positive effects, and that these effects will be more marked and lasting in the developing – compared to the mature – brain.
Failure To Report Information Affecting Public Safety -- NSPE Case No. 90-5
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Confidentiality
Engineer/Client Relationships
Ethics and Society
Public Well-being
Research and Practice
Risk
Safety
Social Justice
Social Responsibility
Workplace Ethics

description: Tenants sue their building's owner, and the owner employs an engineer who finds structural defects not mentioned in the tenants' lawsuit. Issues of public safety versus client confidentiality.
title: Targeted Combination Treatment for Glioblastoma Multiforme (GBM) Using Polymeric Nanoparticle
Creators: name: Velpurisiva, Praveena
name: Tilton, Michael
name: Piel, Brandon
name: Rai, Prakash
Publisher: name: eScholarship@UMMS
Year: 2016

description: Glioblastoma Multiforme (GBM) is an aggressive cancer that originates from astrocytes and spreads to spinal cord and other parts of the brain. Increase in replication of glial cells leads to advantageous mutations in the tumor. In 2015 about 15,320 deaths were reported due to GBM. Five-year survival is less than 5% making GBM a dreadful cancer. Current treatment involves complex invasive surgery, followed by chemotherapy and radiation. There is a desperate unmet need for a targeted treatment of GBM with minimum damage to the surrounding normal tissue. Combination treatments are increasingly being used to target multiple hallmarks of cancer. The goal of this study is to develop a combination therapy to treat GBM using Poly (lactic-co-glycolic acid) (PLGA) nanoparticles encapsulated with three different drugs namely gefitinib, temozolomide (TMZ) and GSK461364 each with a unique target. Nanoparticles facilitate combination of multiple drugs for simultaneous delivery to cancer cells in a single nano-sized platform. Gefitinib is a Tyrosine Kinase inhibitor, which competes for ATP-binding site of EGFR-TK. TMZ methylates DNA of tumor cells, resulting in apoptosis. GSK461364 is a Polo-like Kinase (PLK-1) inhibitor that blocks the G2/M transition in tumor cell cycle. These three distinct hydrophobic drugs are tested on U-87 MG (human malignant glioma) and MDA-MB-231 (triple negative breast cancer) cell lines. PLGA is attached to Polyethylene glycol (PEG), which is conjugated to transferrin receptor (TfR) binding peptide for targeting TfR overexpression, common in GBM. PEG is known to increase the circulation half-life in vivo and improves colloidal stability of nanoparticles. These transferrin peptides bind to TfR (or CD71) and enable the entry of PLGA across Blood Brain Barrier (BBB). Results of characterization, in vitro drug release profiles, stability at 37C and 4C, cytotoxicity assay, electron micrographs of nanoparticles containing drugs and fluorescent imaging will be presented.
Evidence of surface loss as ubiquitous limiting damping mechanism in SiN micro- and nanomechanical resonators
Creators: name: Villanueva, Luis Guillermo
name: Schmid, Silvan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Silicon nitride (SiN) micro- and nanomechanical resonators have attracted a lot of attention in various research fields due to their exceptionally high quality factors ($Q$s). Despite their popularity, the origin of the limiting loss mechanisms in these structures has remained controversial. In this paper we propose an analytical model combining acoustic radiation loss with intrinsic loss. The model accurately predicts the resulting mode-dependent $Q$s of a low-stress silicon-rich and a high-stress stoichiometric SiN membrane. The large acoustic mismatch of the low-stress membrane to the substrate seems to minimize radiation loss and $Q$s of higher modes ($n \wedge m \geq 3$) are limited by intrinsic losses. The study of these intrinsic losses in low-stress membranes with varying lengths $L$ and thicknesses $h$ reveals an inverse linear dependence of the intrinsic loss with $h$ for thin resonators independent of $L$. This finding was confirmed by comparing the intrinsic dissipation of arbitrary (membranes, strings, and cantilevers) SiN resonators extracted from literature, suggesting surface loss as ubiquitous damping mechanism in thin SiN resonators with $Q_{surf} = β\cdot h$ and $β= 6\times10^{10} \pm4\times 10^{10}$~m$^{-1}$. Based on the intrinsic loss the maximal achievable $Q$s and $Q\cdot f$ products for SiN membranes and strings are outlined.
The collapse of cooperation in evolving games
Creators: name: Stewart, Alexander J.
name: Plotkin, Joshua B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Game theory provides a quantitative framework for analyzing the behavior of rational agents. The Iterated Prisoner's Dilemma in particular has become a standard model for studying cooperation and cheating, with cooperation often emerging as a robust outcome in evolving populations. Here we extend evolutionary game theory by allowing players' strategies as well as their payoffs to evolve in response to selection on heritable mutations. In nature, many organisms engage in mutually beneficial interactions, and individuals may seek to change the ratio of risk to reward for cooperation by altering the resources they commit to cooperative interactions. To study this, we construct a general framework for the co-evolution of strategies and payoffs in arbitrary iterated games. We show that, as payoffs evolve, a trade-off between the benefits and costs of cooperation precipitates a dramatic loss of cooperation under the Iterated Prisoner's Dilemma; and eventually to evolution away from the Prisoner's Dilemma altogether. The collapse of cooperation is so extreme that the average payoff in a population may decline, even as the potential payoff for mutual cooperation increases. Our work offers a new perspective on the Prisoner's Dilemma and its predictions for cooperation in natural populations; and it provides a general framework to understand the co-evolution of strategies and payoffs in iterated interactions.
description: 33 pages, 13 figures
title: Pre-exposure prophylaxis with OspA-specific human monoclonal antibodies protects mice against tick transmission of Lyme disease spirochetes
Creators: name: Wang, Yang
name: Kern, Aurélie
name: Boatright, Naomi
name: Schiller, Zachary
name: Sadowski, Andrew
name: Ejemel, Monir
name: Souders, Colby A.
name: Reimann, Keith A.
name: Hu, Linden
name: Thomas, William D.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Background. Tick transmission of Borrelia spirochetes to humans results in significant morbidity from Lyme disease worldwide. Serum concentrations of antibodies against outer surface protein A (OspA) were shown to correlate with protection from infection with Borrelia burgdorferi, the primary cause of Lyme disease in the United States.

Methods. Mice transgenic for human immunoglobulin genes were immunized with OspA protein of B. burgdorferi to generate human monoclonal antibodies (HuMabs) against OspA. HuMabs were generated and tested in in vitro borreliacidal assays and animal protection assays.

Results. Nearly 100 unique OspA specific HuMabs were generated and four HuMabs (221-7, 857-2, 319-44, and 212-55) were selected as lead candidates based on borreliacidal activity. HuMab 319-44, 857-2 and 212-55 were borreliacidal against one or two Borrelia genospecies, whereas 221-7 was borreliacidal (IC50 < 1nM) against B. burgdorferi, B. afzelii and B. garinii, the three main genospecies endemic in the US, Europe and Asia. All four HuMabs completely protected mice from infection at 10 mg/kg in a murine model of tick-mediated transmission of B. burgdorferi.

Conclusions. Our study indicates that OspA-specific HuMabs can prevent the transmission of Borrelia and administration of these antibodies could be employed as pre-exposure prophylaxis for Lyme disease.
One-loop Modified Gravity in de Sitter Universe, Quantum Corrected Inflation, and its Confrontation with the Planck Result
Creators: name: Bamba, Kazuharu
name: Cognola, Guido
name: Odintsov, Sergei D.
name: Zerbini, Sergio
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Motivated by issues on inflation, a generalized modified gravity model is investigated, where the model Lagrangian is described by a smooth function $f(R, K, ϕ)$ of the Ricci scalar $R$, the kinetic term $K$ of a scalar field $ϕ$. In particular, the one-loop effective action in the de Sitter background is examined on-shell as well as off-shell in the Landau gauge. In addition, the on-shell quantum equivalence of $f(R)$ gravity in the Jordan and Einstein frames is explicitly demonstrated. Furthermore, we present applications related to the stability of the de Sitter solutions and the one-loop quantum correction to inflation in quantum-corrected $R^2$ gravity. It is shown that for a certain range of parameters, the spectral index of the curvature perturbations can be consistent with the Planck analysis, but the tensor-to-scalar ratio is smaller than the minimum value within the 1 $σ$ error range of the BICEP2 result.
description: 21 pages, no figure, several references added
Resurrecting Quadratic Inflation in No-Scale Supergravity in Light of BICEP2
Creators: name: Ellis, John
name: Garcia, Marcos A. G.
name: Nanopoulos, Dimitri V.
name: Olive, Keith A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The magnitude of primordial tensor perturbations reported by the BICEP2 experiment is consistent with simple models of chaotic inflation driven by a single scalar field with a power-law potential \propto ϕ^n: n \simeq 2, in contrast to the WMAP and Planck results, which favored models resembling the Starobinsky R + R^2 model if running of the scalar spectral index could be neglected. While models of inflation with a quadratic potential may be constructed in simple N=1 supergravity, these constructions are more challenging in no-scale supergravity. We discuss here how quadratic inflation can be accommodated within supergravity, focussing primarily on the no-scale case. We also argue that the quadratic inflaton may be identified with the supersymmetric partner of a singlet (right-handed) neutrino, whose subsequent decay could have generated the baryon asymmetry via leptogenesis.
description: 24 pages, 14 figures
title: Differences in Complication Rates Between Roux-en-Y Gastric Bypass and Longitudinal Sleeve Gastrectomy
Creators: name: Weitzner, Zachary
name: Flahive, Julie
name: Fitzgerald, Gordon
name: Czerniach, Donald
name: Cohen, Philip
name: Kelly, John
name: Perugini, Richard A.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Introduction: Sleeve Gastrectomy (SG) has surpassed Roux-en-Y Gastric Bypass (RYGB) as the most commonly performed bariatric operation. Though the beneficial effect of SG on Type 2 Diabetes Mellitus is less than that of RYGB, it is perceived to have a lower complication rate. The purpose of this study was to quantify the complication rates between of SG and RYGB in a severely obese diabetic population.

Methods: This was a retrospective cohort study that included all diabetic patients undergoing RYGB and SG at an academic medical center from January 1, 2011 to July 1, 2015. Patients were followed at 6 week, 6 month, 1 year, 2 year, and 3 year postoperatively. Outpatient and emergency visits were identified in the EMR system. Continuous data was analyzed using Student T tests and discrete data was analyzed using Fisher’s Exact Test. We defined early complications as those occurring within 30 days postoperatively, and late complications as those after 30 days.

Results: A total of 96 patients underwent RYGB and 89 underwent SG. The groups were concurrent and similar with regards to preoperative demographic factors such as age, gender, Hgb-A1c, HOMA2 parameters, excess body weight, BMI, and diabetic medication use. In terms of early complications, the rate of hemorrhage requiring transfusion was higher in the SG group compared to RYGB (10.1% vs. 3.1%, p=0.073). Postoperative length of stay was lower in the SG group (m=1.7 d vs. m=2 d, p=0.02), but the early readmission rate was also higher in the SG group (7.9% vs. 2.1%, p=0.09). For late postoperative complications, there were 4 anastomotic ulcer perforations and one case of internal hernia in the RYGB group. There were 6 late postoperative reoperations in the RYGB group (6% vs. 0%, p=0.03). In addition, 13 patients underwent 16 total upper endoscopies in the RYGB group (13.5% vs. 0%, p=0.0002). The cumulative rate of early and late interventions was higher in the RYGB group (20% vs. 3.4%, p=0.0005).

Conclusions: While the rate of early postoperative complication is similar between SG and RYGB, the need for late intervention is higher after RYGB. The cumulative need for reintervention (early and late) is higher after RYGB. This may explain the shift from Roux-en-Y Gastric Bypass to Sleeve Gastrectomy as the most commonly performed bariatric intervention.
Secular orbital evolution of planetary systems and the dearth of close-in planets around fast rotators
Creators: name: Lanza, A. F.
name: Shkolnik, E. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recent analyses of Kepler space telescope data reveal that transiting planets with orbital periods shorter than about 2-3 days are generally observed around late-type stars with rotation periods longer than about 5-10 days. We investigate different explanations for this phenomenon and favor an interpretation based on secular perturbations in multi-planet systems on non-resonant orbits. In those systems, the orbital eccentricity of the innermost planet can reach values close to unity through a process of chaotic diffusion of its orbital elements in the phase space. When the eccentricity of the innermost orbit becomes so high that the periastron gets closer than about 0.05 AU, tides shrink and circularize the orbit producing a close-in planet on a timescale shorter than about 50 Myr. The probability of high eccentricity excitation and subsequent circularization is estimated and is found to increase with the age of the system. Thus, we are able to explain the observed statistical correlation between stellar rotation and minimum orbital period of the innermost planet by using the stellar rotation period as a proxy of its age through gyrochronology. Moreover, our model is consistent with the entire observed distributions of the rotation and orbital periods for orbital periods between 3 and 15 days.
description: 13 pages, 7 figures, accepted by Monthly Notices of the Royal Astronomical Society
title: Text Mining From Drug Surveillance Report Narratives
Creators: name: Wunnava, Susmitha
name: Kakar, Tabassum
name: Qi, Xiao
name: Rudensteiner, Elke A.
Publisher: name: eScholarship@UMMS
Year: 2016

description: Analysis of postmarket drug surveillance reports is imperative to ensure drug safety and effectiveness. FAERS (FDA Adverse Event Reporting System) is a surveillance system that monitors Adverse Events (AEs) from drugs and biologic products. The AEs are reported through MedWatch voluntary reports (initiated from patients and healthcare providers) and mandatory reports (initiated from manufacturers). Much of the information in the voluntary AE reports is narratives or unstructured text. The increasing volume of individual reports, estimated at more than one million per year, poses a challenge for the staff to review large volume of narratives for drug clinical review. We are developing a computational approach using Natural Language Processing and UMLS MetaMap biomedical software to parse the narratives, recognize named-entities in the text and extract consumer/patient and related drug indications and adverse drug reaction information. The goal is to develop a text mining tool that automatically extracts relevant information from the report narratives which can be stored in pre-defined data fields in the FAERS database for efficient searching and querying during clinical review process.