title: Ð¡Ð¸ÑÑÑÐ¸Ð½Ñ Ð¸ ÑÐ°ÐºÑÐ¾ÑÑ ÑÐ¾ÑÑÐ° ÑÐ¸ÑÐ½Ð¸ÐºÐ¾Ð² Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð¿ÐµÑÐ¸Ð¾Ð´Ñ Ð¾Ð½ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Sirtuins and ovarian growth factors at different periods of ontogenesis
Creators: name: ÐÑÑÐ°ÑÐ¼ÐµÑÐ¾Ð²Ð°, ÐÐ»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐ¸ÑÐ½Ð¸ÐºÐ¸
ÑÐ¸ÑÑÑÐ¸Ð½ 1
ÑÐ¸ÑÑÑÐ¸Ð½ 6
ÑÐ°ÐºÑÐ¾Ñ ÑÐ¾ÑÑÐ° ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ ÑÐ¾ÑÑÐ´Ð¾Ð²
ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐ¾ÑÑÐ¾Ð²Ð¾Ð¹ ÑÐ°ÐºÑÐ¾Ñ Ð±ÐµÑÐ°
ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ ÑÐ¸ÑÐ½Ð¸ÐºÐ°
ÑÑÐ°ÑÐµÐ½Ð¸Ðµ
ovaries
sirtuin 1
sirtuin 6
vessels endo-telium growth factor
transforming beta growth factor
ovarian development
aging

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÑÐ¸ÑÑÑÐ¸Ð½Ð° 1, ÑÐ¸ÑÑÑÐ¸Ð½Ð° 6, ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ¾ÑÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° Ð±ÐµÑÐ° Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ° ÑÐ¾ÑÑÐ° ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ ÑÐ¾ÑÑÐ´Ð¾Ð² Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð¿ÐµÑÐ¸Ð¾Ð´Ñ Ð¾Ð½ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð° ÑÐ¸ÑÐ½Ð¸ÐºÐ¾Ð². Ð Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð±ÑÐ»Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸: Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð´Ð»Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ¸ÑÑÑÐ¸Ð½Ð° 1, ÑÐ¸ÑÑÑÐ¸Ð½Ð° 6, ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ¾ÑÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° Ð±ÐµÑÐ° Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ° ÑÐ¾ÑÑÐ° ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ ÑÐ¾ÑÑÐ´Ð¾Ð², ÑÐ»ÑÐ¾ÑÐµÑÑÐµÐ½ÑÐ½Ð°Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ Ð´Ð»Ñ Ð²Ð¸Ð·ÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð². Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð° Ð²ÑÑÐ²Ð»ÐµÐ½Ð° Ð¾ÑÑÐ¸ÑÐ°ÑÐµÐ»ÑÐ½Ð°Ñ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ñ Ð¼ÐµÐ¶Ð´Ñ Ð²Ð¾Ð·ÑÐ°ÑÑÐ¾Ð¼ Ð¸ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´ÑÑ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÑÐ¸ÑÑÑÐ¸Ð½Ð° 1, ÑÐ¸ÑÑÑÐ¸Ð½Ð° 6 Ð¸ ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ¾ÑÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° Ð±ÐµÑÐ°. ÐÐ¾Ð»ÑÑÐµÐ½Ñ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐ²ÑÐ·Ð¸ Ð¼ÐµÐ¶Ð´Ñ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ð°Ð¼Ð¸, ÑÐ°Ðº, ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ¾ÑÑÐ¾Ð²Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° Ð±ÐµÑÐ° Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ° ÑÐ¾ÑÑÐ° ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ ÑÐ¾ÑÑÐ´Ð¾Ð² Ð² ÑÐ¸ÑÐ½Ð¸ÐºÐµ ÐºÐ¾ÑÑÐµÐ»Ð¸ÑÑÐµÑ Ñ ÑÐ¸Ð½ÑÐµÐ·Ð¾Ð¼ ÑÐ¸ÑÑÑÐ¸Ð½Ð° 1, ÑÐ°ÐºÐ¶Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ ÑÑÐ°Ð½ÑÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ¾ÑÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° Ð±ÐµÑÐ° ÐºÐ¾ÑÑÐµÐ»Ð¸ÑÑÐµÑ Ñ ÑÐ¸Ð½ÑÐµÐ·Ð¾Ð¼ ÑÐ¸ÑÑÑÐ¸Ð½Ð° 6. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ» ÑÐ´ÐµÐ»Ð°Ð½ Ð²ÑÐ²Ð¾Ð´ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð¸Ð·ÑÑÐµÐ½Ð½ÑÑ Ð¼Ð¾Ð»ÐµÐºÑÐ» Ð½Ð°Ð±Ð»ÑÐ´Ð°ÐµÑÑÑ Ð¿ÑÐ¸ ÑÑÐ°ÑÐµÐ½Ð¸Ð¸ ÑÐ¸ÑÐ½Ð¸ÐºÐ¾Ð² ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°.
description: This work is devoted to the study of the expression of sirtuin 1, sirtuin 6, transforming growth factor beta and vascular endothelial growth factor in various periods of ovarian ontogenesis. The following methods were used in the study: an immunohistochemical study to detect the content of sirtuin 1, sirtuin 6, transforming growth factor beta and vascular endothelial growth factor, and fluorescence microscopy to visualize the results. The study revealed a negative correlation between age and the relative expression area of sirtuin 1, sirtuin 6 and transforming growth factor beta. The correlation between the molecules was obtained, for example, the expression level of transforming growth factor beta and vascular endothelial growth factor in the ovary correlates with the synthesis of sirtuin 1, and the expression of transforming growth factor beta correlates with the synthesis of sirtuin 6. Based on the results of the study, it was concluded that that a decrease in the expression of the studied molecules is observed with aging of the human ovaries.