cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sociality in pre- and post-wean beef calves
Creators: name: Parsons, R.
name: Robbins, J.
name: Dewell, R.
name: Dewll, G.
name: Johnson, A.
name: Haley, D.
name: Millman, S.
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2024

description: Bonding between beef cows and their calves is well established; however, social relationships between calves is less under­stood. In wild ungulates, young calf integration into the natal herd is typically facilitated by its dam based in part on her pre­existing social rank and relationships. Weaning stress occurs when calves are transitioned off milk to solid feed and are com­monly separated from their dam. Research is lacking on pref­erential relationships between calves during both the pre-wean and the post-wean periods. The objective of this study was to explore the relationships between calves during both the pre-wean and post-wean periods.
description: American Association of Bovine Practitioners Conference Proceedings, No. 56 (2023): 2023 Annual Conference Proceedings
Magnetic Resonance Imaging Diagnosis of Hepatocellular Carcinoma in Cirrhotic Patients: Where Are We Now?
Creators: name: Ramalho, Miguel
name: Semelka, Richard C
name: Matos, António P
name: AlObaidy, Mamdoh
Publisher: name: Ordem dos Medicos
Year: 2016

description: INTRODUCTION Hepatocellular carcinoma (HCC) is the sixth most com-monly  diagnosed  cancer  worldwide,  usually  developing within a cirrhotic background.
Additional file 4 of Gene expression during the formation of resting spores induced by nitrogen starvation in the marine diatom Chaetoceros socialis
Creators: name: Pelusi, Angela
name: Ambrosino, Luca
name: Miralto, Marco
name: Chiusano, Maria Luisa
name: Rogato, Alessandra
name: Ferrante, Maria Immacolata
name: Montresor, Marina
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4. Figure S4
A panoramic view of the accuracy of molecular genetic testing
Creators: name: Schrijver, Iris
name: Weck, Karen E.
Publisher: name: Elsevier
Year: 2016

description: With the significant advancements in molecular diagnostic capabilities over the past several decades, it has become standard practice for a growing number of genetic diagnoses to be made on the basis of molecular genetic test results. Indeed, given the common occurrence of phenotypic overlap among genetic diseases, molecular testing may often be the only way to reach an accurate clinical diagnosis. Moreover, establishing an underlying molecular etiology increasingly influences how genetic conditions are managed.
ASSESSMENT OF DISAGGREGATING THE SDN CONTROL PLANE
Creators: name: Rastegarnia, Adib
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Networking and communications

description: Current SDN controllers have been designed based on a monolithic approach that integrates all of services and applications into one single, huge program. The monolithic design of SDN controllers restricts programmers who build management applications to specific programming interfaces and services that a given SDN controller provides, making application development dependent on the controller, and thereby restricting portability of management applications across controllers. Furthermore, the monolithic approach means an SDN controller must be recompiled whenever a change is made, and does not provide an easy way to add new functionality or scale to handle large networks. To overcome the weaknesses inherent in the monolithic approach, the next generation of SDN controllers must use a distributed, microservice architecture that disaggregates the control plane by dividing the monolithic controller into a set of cooperative microservices. Disaggregation allows a programmer to choose a programming language that is appropriate for each microservice. In this dissertation, we describe steps taken towards disaggregating the SDN control plane, consider potential ways to achieve the goal, and discuss the advantages and disadvantages of each. We propose a distributed architecture that disaggregates controller software into a small controller core and a set of cooperative microservices. In addition, we present a software defined network programming framework called Umbrella that provides a set of abstractions that programmers can use for writing of SDN management applications independent of NB APIs that SDN controllers provide. Finally, we present an intent-based network programming framework called OSDF to provide a high-level policy based API for programming of network devices using SDN.
Supplemental Material, sj-pdf-8-vet-10.1177_03009858211013712 - International Guidelines for Veterinary Tumor Pathology: A Call to Action
Creators: name: Meuten, Donald J.
name: Moore, Frances M.
name: Donovan, Taryn A.
name: Bertram, Christof A.
name: Klopfleisch, Robert
name: Foster, Robert A.
name: Smedley, Rebecca C.
name: Dark, Michael J.
name: Milovancev, Milan
name: Stromberg, Paul
name: Williams, Bruce H.
name: Aubreville, Marc
name: Avallone, Giancarlo
name: Bolfa, Pompei
name: Cullen, John
name: Dennis, Michelle M.
name: Goldschmidt, Michael
name: Luong, Richard
name: Miller, Andrew D.
name: Miller, Margaret A.
name: Munday, John S.
name: Roccabianca, Paola
name: Salas, Elisa N.
name: Schulman, F. Yvonne
name: Laufer-Amorim, Renee
name: Asakawa, Midori G.
name: Craig, Linden
name: Dervisis, Nick
name: Esplin, D. Glen
name: George, Jeanne W.
name: Hauck, Marlene
name: Kagawa, Yumiko
name: Kiupel, Matti
name: Linder, Keith
name: Meichner, Kristina
name: Marconato, Laura
name: Oblak, Michelle L.
name: Santos, Renato L.
name: Simpson, R. Mark
name: Tvedten, Harold
name: Whitley, Derick
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, sj-pdf-8-vet-10.1177_03009858211013712 for International Guidelines for Veterinary Tumor Pathology: A Call to Action by Donald J. Meuten, Frances M. Moore, Taryn A. Donovan, Christof A. Bertram, Robert Klopfleisch, Robert A. Foster, Rebecca C. Smedley, Michael J. Dark, Milan Milovancev, Paul Stromberg, Bruce H. Williams, Marc Aubreville, Giancarlo Avallone, Pompei Bolfa, John Cullen, Michelle M. Dennis, Michael Goldschmidt, Richard Luong, Andrew D. Miller, Margaret A. Miller, John S. Munday, Paola Roccabianca, Elisa N. Salas, F. Yvonne Schulman, Renee Laufer-Amorim, Midori G. Asakawa, Linden Craig, Nick Dervisis, D. Glen Esplin, Jeanne W. George, Marlene Hauck, Yumiko Kagawa, Matti Kiupel, Keith Linder, Kristina Meichner, Laura Marconato, Michelle L. Oblak, Renato L. Santos, R. Mark Simpson, Harold Tvedten and Derick Whitley in Veterinary Pathology
Comparative Studies of Fungal Dimorphism in Dikarya
Creators: name: Kijpornyongpan, Teeratas
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Microbiology not elsewhere classified
Genomics
Bioinformatics and computational biology not elsewhere classified
Evolutionary biology not elsewhere classified
Biochemistry and cell biology not elsewhere classified

description: Fungi display diverse growth forms. Some grow as unicellular yeasts, some grow as multicellular hyphae, while others switch between these two growth forms, i.e., the dimorphic fungi. Dimorphism is found in many pathogenic fungi, and it is thought to be a strategy to maximize their fitness during different stages of life cycles. The corn smut fungus Ustilago maydis serves as a renowned model organism for studying fungal dimorphism and its role in pathogenesis. However, knowledge only from the model species may not be expanded to other species unless multispecies studies have been demonstrated. In this dissertation, I performed comparative analyses to examine if knowledge from U. maydis is translational to other dimorphic fungi. First, a physiological study was conducted to find what can serve as a common signal for dimorphic transition of several Ustilaginomycotina species. I found that the lipid serves as a potential common cue for yeast-to-hyphal transition in most dimorphic species, while alternate types of energy-source carbohydrate do not affect fungal dimorphism. In addition, pectin and high temperature can also trigger filamentous growth in some Ustilaginomycotina species. Second, I performed comparative transcriptomics to determine if a mechanism for yeast-to-hyphal dimorphic transition is conserved across multiple dimorphic species. Three species of Ustilaginomycotina (U. maydis, Tilletiopsis washingtonensis and Meira miltonrushii) plus one species from Ascomycota (Ophiostoma novo-ulmi) were included in the analyses. I found that the similarity of transcriptomic alteration is not dependent on phylogenetic relatedness. Genes in amino acid transport and metabolism, energy production and conversion and cytoskeleton are commonly altered during the dimorphic transition of all studied species. Moreover, I discovered several core genes which can play a conserved role in transducing signals for the dimorphic transition. Finally, I performed comparative analyses of 190 fungal genomes to determine genomic properties that are associated with types of fungal growth form. I found that small genome size is a characteristic for yeast-like fungi. Few indicator genes, such as genes encoding proteins in the NADPH oxidase complex and cytoskeletons, which are predominantly lost in yeast-like fungi in both Ascomycota and Basidiomycota. However, many other genes are associated with types of growth form in a lineage-specific manner. Findings from this dissertation will serve as fundamentals for future research in fungal cell biology, especially in fungal dimorphism. Additionally, results from this study suggest cautions when extrapolating results from model species onto non-model species.
Forced Expiratory Volume in One Second and Patient-Reported Outcomes: Closer Than You Think.
Creators: name: Donahue, James F
Publisher: name: COPD Foundation
Year: 2016

description: Current guidelines for chronic obstructive pulmonary
disease (COPD) now recommend that lung function as
measured by forced expiratory volume in 1 second (FEV1)
be measured alongside patient-reported outcomes
(PRO) in clinical trials of inhaled bronchodilators.
Important elements of COPD management are based on
symptoms, severity, activity limitations or health status.
All are relevant to the approval process and clinical
use. Future risk of disease progression, particularly
exacerbations, must also be considered for management
of stable COPD and for consideration by policy makers
and payers.
Phenomenology of self-interacting WIMPs
Creators: name: Kahlhoefer, Felix
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017

description: GRAPPA seminar, Amsterdam, University of Amsterdam, Netherlands, 24 Apr 2017 - 24 Apr 2017
description: The observed dark matter relic abundance and the idea of thermal freeze-out motivate dark matter particles with weak-scale interactions (so-called WIMPs). On the other hand, discrepancies between numerical simulations and observations on galactic scales prefer models in which dark matter particles have rather strong self-interactions. In my talk I will discuss how to combine these two classes of dark matter models by considering dark matter particles interacting via a new light mediator. I will introduce different types of mediators and discuss the relevant observational and experimental constraints. While the simplest realizations of this set-up are strongly constrained, a number of possible modifications open up a range of interesting possibilities.
Integration of Ferroelectricity into Advanced 3D Germanium MOSFETs for Memory and Logic Applications
Creators: name: Chung, Wonil
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified

description: Germanium-based MOS device which is considered as one of the promising alternative channel materials has been studied with well-known FinFET, nanowire structures and HKMG (High-k metal gate). Recent introduction of Ferroelectric (FE) Zr-doped HfO2 (HfxZr1-xO2, HZO) has opened various possibilities both in memory and logicapplications.
First, integration of FE HZO into the conventional Ge platform was studied to demonstrate Ge FeFET. The FE oxide was deposited with optimized atomic layer deposition (ALD) recipe by intermixing HfO2 and ZrO2. The HZO film was characterized with FE tester, XRD and AR-XPS. Then, it was integrated into conventional gate stack of Ge devices to demonstrate Ge FeFETs. Polarization switching was measured with ultrafast measurement set-up down to 100 ps.
Then, HZO layer was controlled for the first demonstration of hysteresis-free Ge negative capacitance (NC) CMOS FinFETs with sub-60mV/dec SS bi-directionally at room temperature towards possible logic applications. Short channel effect in Ge NCFETs were compared with our reported work to show superior robustness. For smaller widths that cannot be directly written by the e-beam lithography tool, digital etching on Ge fins were optimized.Lastly, Ge FeFET-based synaptic device for neuromorphic computing was demonstrated. Optimum pulsing schemes were tested for both potentiation and depression which resulted in highly linear and symmetric conductance pro files. Simulation was done to analyze Ge FeFET's role as a synaptic device for deep neural network.
Age and Gender Differences in the Associations of Self-Compassion and Emotional Well-being in A Large Adolescent Sample
Creators: name: Gaylord, Susan A.
name: Campo, Rebecca A.
name: Futch, William S.
name: Bluth, Karen
Publisher: name: Springer Nature
Year: 2016

description: Adolescence is a challenging developmental period marked with declines in emotional well-being; however, self-compassion has been suggested as a protective factor. This cross-sectional survey study (N = 765, grades 7th to 12th; 53 % female; 4 % Hispanic ethnicity; 64 % White and 21 % Black) examined whether adolescents’ self-compassion differed by age and gender, and secondly, whether its associations with emotional well-being (perceived stress, life satisfaction, distress intolerance, depressive symptoms, and anxiety) also differed by age and gender. The findings indicated that older females had the lowest self-compassion levels compared to younger females or all-age males. Self-compassion was associated with all emotional well-being measures, and gender and/or age moderated the associations with anxiety and depressive symptoms. Among older adolescents, self-compassion had a greater protective effect on anxiety for boys than for girls. Additionally, older adolescents with low and average self-compassion had greater levels of depressive symptoms than those with high self-compassion. These results may inform for whom and at what age self-compassion interventions may be implemented to protect adolescents from further declines in emotional well-being.
BDSIM simulation model of ATF2 & Background Studies for the Vertical Collimator System
Creators: name: Schuetz, Anne
name: Boogert, S
name: Nevay, L.
name: Snuverink, J.
name: Fuster Martines, N.
name: White, G.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017

description: 20th ATF2 project meeting, Geneva, CERN, Schweiz, 14 Mar 2017 - 15 Mar 2017
description: ATF2 in Japan is a test facility for the final-focus region of the International Linear Collider. In order to proof the functionality of the recently installed vertical beam halo collimator and its impact on the machine backgrounds, background measurements were done in the proximity of the collimator. Additionally, the BDSIM simulation framework is used to put together an ATF2 geometry model and simulate the backgrounds arising from the collimator.
Promotions on Newport and Marlboro Cigarette Packages: A National Study
Creators: name: Ribisl, Kurt M
name: Richardson, Amanda
name: Golden, Shelley D
name: Lee, Joseph G. L
Publisher: name: Oxford University Press (OUP)
Year: 2016

description: INTRODUCTION: While cigarette pack designs are part of integrated marketing efforts, it is unclear the degree to which packs are used to advertise promotions and whether the tobacco retailers' neighborhood characteristics influence the likelihood and type of pack-based promotion in the United States.
METHODS: Between June and October 2012, data collectors purchased packs of either Marlboro Red (n = 1090) or Newport Green (n = 1057) cigarettes at 2147 stores that were part of a national sample of tobacco retailers in the contiguous US. Coders rated packs for the presence of an exterior and interior pack promotion, placement of exterior promotion (eg, front, back), presentation of exterior promotion (eg, onsert, tear strip), and nature of the promotion (eg, contest/give/away). Using Census tract data, we examined the association of pack promotions with tobacco retailers' neighborhood demographic characteristics.
RESULTS: Marlboro packs were approximately twice as likely to have promotions as Newport packs (31.7% vs. 14.7%). Fewer Marlboro packs (14.6%) and no Newport packs had interior promotions. The majority of exterior promotions were for contests (>80% for both brands), while almost all interior Marlboro promotions (97.5%) were for a discounted price. There were few differences in presence or type of promotion by tobacco retailers' neighborhood characteristics.
CONCLUSIONS: Exterior packs promotions, in particular, were fairly common and may contribute to the allure of tobacco products.
IMPLICATIONS: Use of promotions on the interior and exterior of cigarette packs are a mechanism that the tobacco industry uses to sell its products and should be continually assessed for their influence on consumer behavior.
Statistical Guarantee for Non-Convex Optimization
Creators: name: Hao, Botao
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Statistics not elsewhere classified

description: The aim of this thesis is to systematically study the statistical guarantee for two representative non-convex optimization problems arsing in the statistics community. The first one is the high-dimensional Gaussian mixture model, which is motivated by the estimation of multiple graphical models arising from heterogeneous observations. The second one is the low-rank tensor estimation model, which is motivated by high-dimensional interaction model. Both optimal statistical rates and numerical comparisons are studied in depth. In the first part of my thesis, we consider joint estimation of multiple graphical models arising from heterogeneous and high-dimensional observations. Unlike most previous approaches which assume that the cluster structure is given in advance, an appealing feature of our method is to learn cluster structure while estimating heterogeneous graphical models. This is achieved via a high dimensional version of Expectation Conditional Maximization (ECM) algorithm. A joint graphical lasso penalty is imposed on the conditional maximization step to extract both homogeneity and heterogeneity components across all clusters. Our algorithm is computationally efficient due to fast sparse learning routines and can be implemented without unsupervised learning knowledge. The superior performance of our method is demonstrated by extensive experiments and its application to a Glioblastoma cancer dataset reveals some new insights in understanding the Glioblastoma cancer. In theory, a non-asymptotic error bound is established for the output directly from our high dimensional ECM algorithm, and it consists of two quantities: statistical error (statistical accuracy) and optimization error (computational complexity). Such a result gives a theoretical guideline in terminating our ECM iterations. In the second part of my thesis, we propose a general framework for sparse and low-rank tensor estimation from cubic sketchings. A two-stage non-convex implementation is developed based on sparse tensor decomposition and thresholded gradient descent, which ensures exact recovery in the noiseless case and stable recovery in the noisy case with high probability. The non-asymptotic analysis sheds light on an interplay between optimization error and statistical error. The proposed procedure is shown to be rate-optimal under certain conditions. As a technical by-product, novel high-order concentration inequalities are derived for studying high-moment sub-Gaussian tensors. An interesting tensor formulation illustrates the potential application to high-order interaction pursuit in high-dimensional linear regression
Cancer: a global concern that demands new detection technologies
Creators: name: Soper, Steven A
Publisher: name: Royal Society of Chemistry (RSC)
Year: 2016

description: There are over 100 cancer-related diseases and it is becoming clear that the standard-of-care
for managing cancer diseases, which involves physical examinations and assessment of a
patient's symptoms and/or various imaging modalities, is not keeping pace with the
expanding nature of these diseases. For example, while the death rate (per 100,000
individuals) has decreased by 39% over the time span from 1991 to 2015 for cardiovascular
diseases, over this same time period, the death rate for the cancer diseases has only seen a
21% drop. Worldwide, in 2014 there were >13 million new cancer cases and 70% of all
cancer deaths occurred in low to middle income countries; cancer is not restricted to
developed countries only. In the US alone, there were 580,350 cancer deaths and 1.66
million new cases. The (US) National Cancer Institute estimates that cancer care costs were
$125 billion in 2010 and are project to be $200B by 2020! It is abundantly clear that the
future will require new paradigms for managing all cancer-related diseases, such as
molecular diagnostics/prognostics
A heart team and multi-modality imaging approach to percutaneous closure of a post-myocardial infarction ventricular septal defect
Creators: name: Yeung, Michael
name: Bauer, Thurston
name: Kiser, Andy C
name: Iyer, Sunil
name: Ramm, Cassandra
name: Vavalle, John P
name: Caranasos, Thomas G
Publisher: name: AME Publishing Company
Year: 2016

description: Post-infarction ventricular septal defect (PI-VSD) is a devastating complication that carries a high mortality with or without surgical repair. Percutaneous closure is an attractive alternative in select patients though requires appropriate characterization of the PI-VSD as well as careful device and patient selection. We describe a multidisciplinary and multi-modality imaging approach to successful percutaneous closure of a PI-VSD.
Cosmic-ray electron-positron spectrum from 7 GeV to 2 TeV with the Fermi Large Area Telescope
Creators: name: Abdollahi, S.
name: Ackermann, Markus
name: Ajello, M.
name: Atwood, W. B.
name: Baldini, L.
name: Barbiellini, G.
name: Bastieri, D.
name: Bellazzini, R.
name: Bloom, E. D.
name: Bonino, R.
name: Brandt, T. J.
name: Bregeon, J.
name: Bruel, P.
name: Buehler, R.
name: Cameron, R. A.
name: Caputo, R.
name: Caragiulo, M.
name: Castro, D.
name: Cavazzuti, E.
name: Cecchi, C.
name: Chekhtman, A.
name: Ciprini, S.
name: Cohen-Tanugi, J.
name: Costanza, F.
name: Cuoco, A.
name: Cutini, S.
name: D’Ammando, F.
name: De Palma, F.
name: Desiante, R.
name: Digel, S. W.
name: Di Lalla, N.
name: Di Mauro, M.
name: Di Venere, L.
name: Drell, P. S.
name: Drlica-Wagner, A.
name: Favuzzi, C.
name: Focke, W. B.
name: Funk, S.
name: Fusco, P.
name: Gargano, F.
name: Gasparrini, D.
name: Giglietto, N.
name: Giordano, F.
name: Giroletti, M.
name: Green, D.
name: Guillemot, L.
name: Guiriec, S.
name: Harding, A. K.
name: Jogler, T.
name: Jóhannesson, G.
name: Kamae, T.
name: Kuss, M.
name: La Mura, G.
name: Latronico, L.
name: Longo, F.
name: Loparco, F.
name: Lubrano, P.
name: Maldera, S.
name: Malyshev, D.
name: Manfreda, A.
name: Mazziotta, M. N.
name: Michelson, P. F.
name: Mirabal, N.
name: Mitthumsiri, W.
name: Mizuno, T.
name: Moiseev, A. A.
name: Monzani, M. E.
name: Morselli, A.
name: Moskalenko, I. V.
name: Negro, M.
name: Nuss, E.
name: Orlando, E.
name: Paneque, D.
name: Perkins, J. S.
name: Pesce-Rollins, M.
name: Piron, F.
name: Pivato, G.
name: Porter, T. A.
name: Principe, G.
name: Rainò, S.
name: Rando, R.
name: Razzano, M.
name: Reimer, A.
name: Reimer, O.
name: Sgrò, C.
name: Simone, D.
name: Siskind, E. J.
name: Spada, F.
name: Spandre, G.
name: Spinelli, P.
name: Tajima, H.
name: Thayer, J. B.
name: Tibaldo, L.
name: Torres, D. F.
name: Troja, E.
name: Wood, M.
name: Worley, A.
name: Zaharijas, G.
name: Zimmer, S.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017
Subjects: subject: 530

description: (2017). doi:10.1103/PhysRevD.95.082007
description: We present a measurement of the cosmic-ray electron+positron spectrum between 7 GeV and 2 TeV performed with almost seven years of data collected with the Fermi Large Area Telescope. We find that the spectrum is well fit by a broken power law with a break energy at about 50 GeV. Above 50 GeV, the spectrum is well described by a single power law with a spectral index of 3.07±0.02(stat+syst)±0.04(energy measurement). An exponential cutoff lower than 1.8 TeV is excluded at 95\% CL.
Hydroxychloroquine As a Steroid-Sparing Agent in an Infant with Chronic Urticaria
Creators: name: Wu, Eveline Y.
name: Copenhaver, Christopher C.
name: Moran, Timothy P.
name: Iweala, Onyinye I.
Publisher: name: Elsevier
Year: 2016

description: Rationale
In adults, hydroxychloroquine is one anti-inflammatory steroid-sparing agent used to treat chronic idiopathic urticaria (CIU) refractory to antihistamines. Whether hydroxychloroquine is safe and effective for antihistamine-refractory CIU in children is unknown.
Methods
We present an infant with resolution of antihistamine-refractory CIU following treatment with hydroxychloroquine and concomitant discontinuation of steroids.
Results
A 9-month-old male infant presented with a 5-month history of recurrent unprovoked urticaria and angioedema of the hands and feet refractory to high-dose H1 and H2 antihistamines and leukotriene antagonists. Physical examination revealed diffuse pleomorphic urticaria and marked dermatographism. Laboratory testing demonstrated an elevated platelet count (534,000/microliter) and C-reactive protein (CRP, 2.0 mg/dL). Serum tryptase, C3, C4, and C1q were normal. Antinuclear, anti-thyroid, and anti-IgE receptor antibodies were negative; cow’s milk specific IgE was undetectable. Skin biopsy showed perivascular lymphocytic infiltrate, perivascular to interstitial eosinophils, no neutrophilic infiltrate or evidence of urticarial vasculitis. Symptoms were moderately well controlled by adding oral prednisolone (0.65 mg/kg) every other day but rebounded if steroids were tapered further. Hydroxychloroquine 2mg/kg/day was initiated and up-titrated to 6 mg/kg/day over 3 months, and platelet count and CRP normalized. Adverse reactions included diarrhea that resolved with dose modification. After 3 months of hydroxychloroquine (at age 12 months), prednisolone taper was initiated. Prednisolone was discontinued by age 14 months without recurrence of urticaria or angioedema.
Conclusions
While further study is needed, we demonstrate that hydroxychloroquine can be a safe and effective treatment for antihistamine-refractory CIU in children, leading to down-titration and subsequent cessation of systemic steroid therapy.
Supplemental Material, sj-pdf-1-jmx-10.1177_00222429211014902 - Virtual Reality in New Product Development: Insights from Pre-launch Sales Forecasting for Durables
Creators: name: Harz, Nathalie
name: Hohenberg, Sebastian
name: Homburg, Christian
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, sj-pdf-1-jmx-10.1177_00222429211014902 for Virtual Reality in New Product Development: Insights from Pre-launch Sales Forecasting for Durables by Nathalie Harz, Sebastian Hohenberg and Christian Homburg in Journal of Marketing
Transformative Treatments
Creators: name: Paul, L.A.
name: Healy, Kieran
Publisher: name: Wiley
Year: 2016

description: Contemporary social‐scientific research seeks to identify specific causal mechanisms for outcomes of theoretical interest. Experiments that randomize populations to treatment and control conditions are the “gold standard” for causal inference. We identify, describe, and analyze the problem posed by transformative treatments . Such treatments radically change treated individuals in a way that creates a mismatch in populations, but this mismatch is not empirically detectable at the level of counterfactual dependence. In such cases, the identification of causal pathways is underdetermined in a previously unrecognized way. Moreover, if the treatment is indeed transformative it breaks the inferential structure of the experimental design. Transformative treatments are not curiosities or “corner cases,” but are plausible mechanisms in a large class of events of theoretical interest, particularly ones where deliberate randomization is impractical and quasi‐experimental designs are sought instead. They cast long‐running debates about treatment and selection effects in a new light, and raise new methodological challenges.
A system for automated outbreak detection of communicable diseases in Germany
Creators: name: Salmon, Maëlle
name: Schumacher, D.
name: Burmann, Hendrik
name: Frank, Christina
name: Claus, Hermann
name: Höhle, Michael
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: surveillance
subject: automated surveillance epidemiology
subject: informatics
subject: outbreaks
subject: software
subject: statistics
subject: 610 Medizin

description: We describe the design and implementation of a novel automated outbreak detection system in Germany that monitors the routinely collected surveillance data for communicable diseases. Detecting unusually high case counts as early as possible is crucial as an accumulation may indicate an ongoing outbreak. The detection in our system is based on state-of-the-art statistical procedures conducting the necessary data mining task. In addition, we have developed effective methods to improve the presentation of the results of such algorithms to epidemiologists and other system users. The objective was to effectively integrate automatic outbreak detection into the epidemiological workflow of a public health institution. Since 2013, the system has been in routine use at the German Robert Koch Institute.
Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models
Creators: name: Shelton, Sarah E.
name: Foster, F. Stuart
name: Lindsey, Brooks D.
name: Dayton, Paul A.
Publisher: name: Springer Nature
Year: 2016

description: Purpose The purposes of the present study is to evaluate a new ultrasound molecular imaging approach in its ability to image a preclinical tumor model and to investigate the capacity to visualize and quantify co-registered microvascular and molecular imaging volumes. Procedures Molecular imaging using the new technique was compared with a conventional ultrasound molecular imaging technique (multi-pulse imaging) by varying the injected microbubble dose and scanning each animal using both techniques. Each of the 14 animals was randomly assigned one of three doses; bolus dose was varied, and the animals were imaged for three consecutive days so that each animal received every dose. A microvascular scan was also acquired for each animal by administering an infusion of nontargeted microbubbles. These scans were paired with co-registered molecular images (VEGFR2-targeted microbubbles), the vessels were segmented, and the spatial relationships between vessels and VEGFR2 targeting locations were analyzed. In five animals, an additional scan was performed in which the animal received a bolus of microbubbles targeted to E- and P-selectins. Vessel tortuosity as a function of distance from VEGF and selectin targeting was analyzed in these animals. Results Although resulting differences in image intensity due to varying microbubble dose were not significant between the two lowest doses, superharmonic imaging had significantly higher contrast-to-tissue ratio (CTR) than multi-pulse imaging (mean across all doses 13.98 dB for molecular acoustic angiography vs. 0.53 dB for multi-pulse imaging; p = 4.9 × 10−10). Analysis of registered microvascular and molecular imaging volumes indicated that vessel tortuosity decreases with increasing distance from both VEGFR2- and selectin-targeting sites. Conclusions Molecular acoustic angiography (superharmonic molecular imaging) exhibited a significant increase in CTR at all doses tested due to superior rejection of tissue artifact signals. Due to the high resolution of acoustic angiography molecular imaging, it is possible to analyze spatial relationships in aligned microvascular and molecular superharmonic imaging volumes. Future studies are required to separate the effects of biomarker expression and blood flow kinetics in comparing local tortuosity differences between different endothelial markers such as VEGFR2, E-selectin, and P-selectin.
Budesonide for the treatment of ulcerative colitis
Creators: name: Abdalla, Maisa I.
name: Herfarth, Hans
Publisher: name: Taylor & Francis
Year: 2016

description: INTRODUCTION: Budesonide is a synthetic corticosteroid characterized by enhanced topical potency and limited systemic bioavailability. Its use in ulcerative colitis (UC) was limited to rectal preparations until recently when the new oral budesonide formulation incorporating the multi-matrix system technology was introduced. The purpose of this review is to evaluate the current role of oral and rectal budesonide in managing UC patients Areas covered: In this paper, we described the chemical structure and pharmacologic characteristics of the different oral and rectal budesonide preparations, provided a summary of the published trials that evaluated the efficacy and safety of budesonide in UC, and discussed the current status of its use in this population Expert opinion: Budesonide is effective in inducing remission in a subset of patients with mild-moderate UC. Nevertheless, the current evidence suggests inferiority of oral budesonide to 5-aminosalisylates (5-ASA) and systemic steroids, whereas rectal applications are comparable to other rectal steroid preparations, but still inferior to rectal 5-ASA. In clinical practice, several issues need clarification including, its exact position in the line of induction agents; the role of combining budesonide and 5-ASAs; the role of combining oral and rectal budesonide; and the role of budesonide in maintenance therapy.
Bayesian estimation of sensitivity and specificity of IgG and serum total protein cutoff values for the diagnosis of failed transfer of passive immunity in neonatal beef calves
Creators: name: Thompson, A.
name: Scott, M.
name: Smith, D.
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2024

description: Calves with failed transfer of passive immunity (FTPI) possess increased risk of preweaning disease. Common tests for FTPI such as radial immunodiffusion (RID) and optical refractom­etry (OR) have inherent imprecision. The objective of this study was to estimate test sensitivity and specificity for various IgG concentrations and serum total protein values (STP) to classify neonatal beef calves with FTPI.
description: American Association of Bovine Practitioners Conference Proceedings, No. 56 (2023): 2023 Annual Conference Proceedings
A Life Course Approach to Health in the Ancient Nile Valley
Creators: name: Whitmore, Katie Marie
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Anthropology not elsewhere classified

description: This dissertation employs a multiscalar, life course approach to examine health in the ancient Nile Valley (c. 2000- 660 BCE) by analyzing population- and individual-level data of skeletal indicators of stress, health, and pathological conditions. Specifically, this dissertation explores a more detailed reconstruction of health under a life course approach through the inclusion of individuals of all ages, a contextualization of social and biological age categories, the examination of multiple non-specific indicators of general health/stress, and the timing and development of specific conditions. Results of the population-level data are expanded and highlighted through the examination of individual experiences of health, specifically those related to growing old, impairment, and disability. Population-level data examining cribra orbitalia and LEH demonstrated a significant difference between individuals that survived periods of childhood stress (adults) and non-survivors (juveniles) when examining cribra orbitalia. More specifically, there are relatively high frequencies of cribra orbitalia in individuals in the late juvenile social age category (7 – 14 years) and the transition adult social age category (14 - 20 years). A broad examination of old age at Tombos reveals that many individuals were living into their 60s, 70s, and 80s. Individuals at Tombos do not have many indicators of osteoarthritis or entheseal changes, indicating that the inhabitants of Tombos were not subjected to strenuous physical activities throughout their life. Individuals throughout the Tombos cemetery display oral health issues; it is common for members of this community to have significant dental wear, carious lesions, abscesses, and antemortem tooth loss. A case study of an older Tombos adult (U34.B1) investigates the intersection of old age, impairment, and disability through the consideration of the physical changes related to degenerative joint disease and oral health and the impact to U34.B1’s mobility, pain level, and daily life. Acute care related to a severe, non-union femoral neck fracture at the end of life is also considered for U34.B1. Finally, impairment and disability are considered in another individual (U35.Sh2.B10) with Léri-Weill dyschondrosteosis by utilizing the bioarchaeology of care approach. Overall, this dissertation demonstrates that population-level and individual-level analysis can incorporate various types of contextual data gathered using a culturally specific lens to create a rich narrative of health in the past.
Supplementary Material 1 - Supplemental material for Gender and Counterstereotypical Facial Expressions of Emotion in Crowdfunded Microlending
Creators: name: Davis, Blakley C.
name: Warnick, Benjamin J.
name: Anglin, Aaron H.
name: Allison, Thomas H.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, Supplementary Material 1, for Gender and Counterstereotypical Facial Expressions of Emotion in Crowdfunded Microlending by Blakley C. Davis, Benjamin J. Warnick, Aaron H. Anglin and Thomas H. Allison in Entrepreneurship Theory and Practice
Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base.
Creators: name: Bultman, Scott J
Publisher: name: AME Publishing Company
Year: 2016

description: The mammalian intestinal tract epithelium is renewed every ~4–6 days, which is arguably the most rapidly turned over tissue in the body. Cellular turnover is facilitated by the intestinal epithelium being organized as crypts with highly proliferative stem cells and progenitor/transit-amplifying cells located near the crypt base and quiescent, terminally-differentiated cell types such as enterocytes, goblet cells, and enteroendocrine cells located above that undergo apoptosis and exfoliate into the lumen (Figure 1A). In recent years, tremendous progress has been made identifying Lgr5+ stem cells and crucial factors within the stem-cell niche such as Wnts, R-spondins, BMPs, Noggin, and the Notch pathway (1). This knowledge has been exploited to create 3D organoid culture systems that recapitulate the crypt with respect to stem cell renewal and their ability to give rise to descendants that represent each differentiated cell type.
Predominance of influenza A(H1N1)pdm09 virus genetic subclade 6B.1 and influenza B/Victoria lineage viruses at the start of the 2015/16 influenza season in Europe
Creators: name: Broberg, E.
name: Melidou, A.
name: Prosenc, Katarina
name: Bragstad, K.
name: Hungnes, Olav
name: Schweiger, Brunhilde
name: Wedde, Marianne
name: Biere, Barbara
name: Buda, Silke
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger; Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: surveillance
subject: influenza virus
subject: A(H1N1)pdm09
subject: emergence
subject: influenza B virus
subject: season
subject: 610 Medizin

description: Influenza A(H1N1)pdm09 viruses predominated in the European influenza 2015/16 season. Most analysed viruses clustered in a new genetic subclade 6B.1, antigenically similar to the northern hemisphere vaccine component A/California/7/2009. The predominant influenza B lineage was Victoria compared with Yamagata in the previous season. It remains to be evaluated at the end of the season if these changes affected the effectiveness of the vaccine for the 2015/16 season.
Zikavirus-Infektionen: Tropische Krankheit mit Relevanz für Deutschland
Creators: name: Wilking, Hendrik
name: Faber, Mirko
name: Stark, Klaus
name: Frank, Christina
name: May, Jürgen
name: Schmidt-Chanasit, Jonas
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: 610 Medizin

description: Bisher wurden Zikavirus-Infektionen in Deutschland nur bei Reiserückkehrern nachgewiesen. Das Ansteckungsrisiko durch Mücken ist hierzulande gering, aber nicht ausgeschlossen. Eine sexuelle Übertragung ist möglich.
sj-pdf-1-wes-10.1177_09500170211024467 – Supplemental material for Trade Unions, Bargaining Coverage and Low Pay: A Multilevel Test of Institutional Effects on Low-Pay Risk in Germany
Creators: name: Benassi, Chiara
name: Vlandas, Tim
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-wes-10.1177_09500170211024467 for Trade Unions, Bargaining Coverage and Low Pay: A Multilevel Test of Institutional Effects on Low-Pay Risk in Germany by Chiara Benassi and Tim Vlandas in Work, Employment and Society
Long-chain acyl-CoA synthetase 2 knockdown leads to decreased fatty acid oxidation in fat body and reduced reproductive capacity in the insect Rhodnius prolixus
Creators: name: Klett, Eric L.
name: Ramos, Isabela B.
name: De Paula, Iron F.
name: Coleman, Rosalind A.
name: Alves-Bezerra, Michele
name: Gondim, Katia C.
Publisher: name: Elsevier
Year: 2016

description: Long-chain acyl-CoA esters are important intermediates in lipid metabolism and are synthesized from fatty acids by long-chain acyl-CoA synthetases (ACSL). The hematophagous insect Rhodnius prolixus, a vector of Chagas' disease, produces glycerolipids in the midgut after a blood meal, which are stored as triacylglycerol in the fat body and eggs. We identified twenty acyl-CoA synthetase genes in R. prolixus, two encoding ACSL isoforms (RhoprAcsl1 and RhoprAcsl2). RhoprAcsl1 transcripts increased in posterior midgut on the second day after feeding, and RhoprAcsl2 was highly transcribed on the tenth day. Both enzymes were expressed in Escherichia coli. Recombinant RhoprACSL1 and RhoprACSL2 had broad pH optima (7.5-9.5 and 6.5-9.5, respectively), were inhibited by triacsin C, and were rosiglitazone-insensitive. Both showed similar apparent Km for palmitic and oleic acid (2-6 μM), but different Km for arachidonic acid (0.5 and 6 μM for RhoprACSL1-Flag and RhoprACSL2-Flag, respectively). The knockdown of RhoprAcsl1 did not result in noticeable phenotypes. However, RhoprACSL2 deficient insects exhibited a 2.5-fold increase in triacylglycerol content in the fat body, and 90% decrease in fatty acid β-oxidation. RhoprAcsl2 knockdown also resulted in 20% increase in lifespan, delayed digestion, 30% reduced oviposition, and 50% reduction in egg hatching. Laid eggs and hatched nymphs showed remarkable alterations in morphology. In summary, R. prolixus ACSL isoforms have distinct roles on lipid metabolism. Although RhoprACSL1 functions remain unclear, we propose that RhoprACSL2 is the main contributor for the formation of the intracellular acyl-CoA pool channeled for β-oxidation in the fat body, and is also required for normal reproduction.
The illness of work incapacity
Creators: name: Hadler, Nortin M
Publisher: name: Oxford University Press (OUP)
Year: 2016

description: Aetiology, pathogenesis and translational science beat drums to which modern medicine marches—with escalating cadence. Yes, there is cacophony on occasion and missteps, but we all wait for the next insight to trigger a wave of enthusiasm at the bench and beyond. ‘Disease’ is no longer an elusive monster in the swamp of ignorance; ‘disease’ is prey. It can be defined, parsed, deduced and sometimes defeated.
Storytelling and the National Security of America: Korean War Stories from the Cold War to Post-9/11 Era
Creators: name: Liu, Jingyi
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Literary studies not elsewhere classified
North American literature
Historical studies not elsewhere classified

description: My dissertation is an interdisciplinary study of the Korean War stories in America in relation to the history of the national security state of America from the Cold War to post-911 era. Categorizing the Korean War stories in three phases in parallel with three dramatic episodes in the national security of America, including the institutionalization of national security in the early Cold War, the collapse of the Soviet Union and the bipolar Cold War system in the 1990s, and the institutionalization of homeland security after the 9/11 attacks, I argue that storytelling of the Korean War morphs with the changes of national security politics in America. Reading James Michener’s Korean War stories, Invasion of the Body Snatchers (1956), and The Manchurian Candidate (1962) in the 1950s and early 1960s, I argue that the first-phase Korean War stories cooperated with the state, translating and popularizing key themes in the national security policies through racial and gender tropes. Focusing on Helie Lee’s Still Life with Rice (1996), Susan Choi’s The Foreign Student (1998), and Heinz Insu Fenkl’s Memories of My Ghost Brother (1996) in the 1990s, I maintain that the second-phase Korean War stories by Korean American writers form a narrative resistance against the ideology of national security and provide alternative histories of racial and gender violence in America’s national security programs. Further reading post-911 Korean War novels such as Toni Morrison’s Home (2012), Ha Jin’s War Trash (2005), and Chang-Rae Lee’s The Surrendered (2010), I contend that in the third-phase Korean War stories, the Korean War is deployed as a historical analogy to understand the War on Terror and diverse writers’ revisiting the war offers alternative perspectives on healing and understanding “homeland” for a traumatized American society. Taken together, these Korean War stories exemplify the politics of storytelling that engages with the national security state and the complex ways individual narratives interact with national narratives. Moreover, the continued morphing of the Korean War in literary representation demonstrates the vitality of the “forgotten war” and constantly reminds us the war’s legacy.
การศึกษาและสร้างสรรค์พุทธศิลป์ในวัดสีสะเกด/หอพระแก้ว/พระธาตุหลวง/ ประตูชัยเมืองนครหลวงเวียงจันทน์ สาธารณรัฐประชาธิปไตยประชาชนลาว ในศิลปะรูปแบบโพสต์อิมเพรสชันนิซึม
Creators: name: สาธิต ทิมวัฒนบรรเทิง
Publisher: name: มหาวิทยาลัยมหาสารคาม
Year: 2559
Subjects: พุทธศิลป์

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยมหาสารคาม, 35, 4