cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of Discounts and Offers on Consumer Purchasing Behavior
Creators: name: Priyadharshini S, Dr.Rajesh Kumar K
Publisher: name: Zenodo
Year: 2025

description: This study examines the impact of discounts and offers on consumer purchasing behavior, focusing solely on customer perspectives. Discounts and promotional offers have become vital tools for attracting buyers and increasing sales in today’s competitive retail market. However, their influence on consumer behavior is complex and requires thorough understanding. This research gathers quantitative data from structured surveys distributed among customers to understand how various promotional strategies shape their buying decisions and perceptions of value. The findings indicate that while discounts significantly encourage impulse buying and increase short-term sales, frequent or excessive promotions can lead to a decline in long-term brand loyalty. Many customers develop an expectation of continuous offers, delaying purchases until discounts are available. The study also finds that personalized and targeted discounts are more effective in building customer satisfaction compared to generic promotions. To maintain a balance between short-term gains and long-term customer loyalty, businesses are advised to implement strategic discount practices that focus on perceived value rather than mere price reductions. By adopting a customer-centric approach to discounts and offers, retailers can optimize sales performance while sustaining brand integrity and consumer trust.
Supplemental Material, supplementary_table_1-TCRT-17-0031.R3 - DCE-MRI-Derived Volume Transfer Constant (Ktrans) and DWI Apparent Diffusion Coefficient as Predictive Markers of Short- and Long-Term Efficacy of Chemoradiotherapy in Patients With Esophageal Cancer
Creators: name: Ye, Zhi-Min
name: Dai, Shu-Jun
name: Yan, Feng-Qin
name: Wang, Lei
name: Fang, Jun
name: Fu, Zhen-Fu
name: Wang, Yue-Zhen
Publisher: name: SAGE Journals
Year: 2018
Subjects: Biochemistry
Radiology and Organ Imaging
Oncology and Carcinogenesis not elsewhere classified

description: Supplemental Material, supplementary_table_1-TCRT-17-0031.R3 for DCE-MRI-Derived Volume Transfer Constant (Ktrans) and DWI Apparent Diffusion Coefficient as Predictive Markers of Short- and Long-Term Efficacy of Chemoradiotherapy in Patients With Esophageal Cancer by Zhi-Min Ye, Shu-Jun Dai, Feng-Qin Yan, Lei Wang, Jun Fang, Zhen-Fu Fu, and Yue-Zhen Wang in Technology in Cancer Research & Treatment
Ensuring Healthcare System Integrity With Blockchain
Creators: name: I. L?Hmus
Publisher: name: Zenodo
Year: 2016

description: Blockchain, the underlying protocol behind Bitcoin, has received a tremendous amount of attention over the last two years. Whilst initially focused on financial services, the technology holds much promise for addressing challenges in health-care system. Electronic health records and related information systems have several advantages over historical paper-based management - smooth data transfer between medical care providers, patient empowerment etc. While being convenient and effient these systems always raise security concerns - how to ensure that such sensitive data is securely stored and how to protect against unauthorized access and manipulation. And ultimately: who can we trust and on what basis? Blockchain technology has huge potential to solve the security issue - and today this is beyond theory - there are blockchain-based security solutions in production.
Guardtime has developed Keyless Signature Infrastructure (KSI) - a blockchain technology for ensuring integrity of data, systems and processes. It provides data signatures that allow to assert integrity, signing time and signing entity of valuable assets - without trusting any central authority. It scales to billions of signatures per second - making it effectively possible to sign and verify every single medical record, access log entry etc.
Estonian Government has been one of the early adopters of the technology and there are integrations in production for several years already. One of the most recent integration is with Estonian E-health Foundation - for securing medical records against tampering and providing means to independently audit the system.
In the presentation I will give an overview of how KSI Blockchain technology works and review how it is applied in Estonian public sector (focusing on the integrations in health-care system).
E-Estonia: Confidentiality, Availability And Integrity In A Dynamic Digital Society
Creators: name: A. Piperal
Publisher: name: Zenodo
Year: 2016

description: Estonia is an incredible success story, grown out of a partnership between a forward-thinking government, a proactive ICT sector and a switched-on, tech-savvy population. Estonia became an early adopter of using ICT for governance, creating a new common-sense in the delivery of state services. Technology was employed to foster public interaction, do business with one another and raise general living conditions ? everything on a truly massive scale. e-Estonia means casting a ballot from the comfort of your own living room during the TV advert break. It means filing your income tax return in just three minutes, or signing a legally-binding contract over the Internet from anywhere in the world via your mobile phone. It means taking a look at your Health record online or getting a prescribed medication with a digital prescription from the comfort of your home. Entrepreneurs can register businesses in as little as 18 minutes; manage their business and submit reports online; check corporate, property and legal records, or even integrate their own secure e-services with the ones offered by the state. Efficient and safe interaction between government agencies, businesses and citizens has been completely transformed in e-Estonia, turning bureaucracy into a thing of the past.
Healthcare field as well as other Estonian state data is protected by a blockchain technology, developed by Guardtime and ensures long-term data integrity and system accountability. Data-centric approach takes into account the reality of cyber era threats and is an ultimate tool for detecting data violations both internal and external, offering insurance while moving critical and private information to the cloud.
The central security element for managing massive data and enabling data, rules, log files integrity is the Keyless Signature Infrastructure - a blockchain technology that is able to verify authenticity of information, prove its integrity independently with no trusted parties using pure math. E-Health system holds millions of health records, X-ray pictures, diagnosis, analysis results and not only gives instant access to the health data for authorized personnel and patients, but as well enables control over the data usage on all levels. Blockchain provides security for the patients, doctors and health sector employees, ensures integrity of the million health records saved and stored and protection over any manipulations, both accidental or intentional.
DevittOpenPracticesDisclosure – Supplemental material for An Optimistic Outlook Creates a Rosy Past: The Impact of Episodic Simulation on Subsequent Memory
Creators: name: Aleea L. Devitt
name: Schacter, Daniel L.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, DevittOpenPracticesDisclosure for An Optimistic Outlook Creates a Rosy Past: The Impact of Episodic Simulation on Subsequent Memory by Aleea L. Devitt and Daniel L. Schacter in Psychological Science
title: Towards the Development of Uranium-Based Electrocatalysts and Redox Flow Batteries
title: Auf dem Weg zu Uran-basierten Elektrokatalysatoren und Redox-Flow-Batterien
Creators: name: Riedhammer, Judith Elisabeth
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: The work documented in this dissertation describes the synthesis of uranium complexes that rely on uranium-ligand cooperativity to support 2e- electrocatalysis, lays the groundwork for a first uranium-based redox flow battery, and derives new uranium-specific ligand field parameters.
Supplemental Appendix - Wages, Informality, and Net Fiscal Benefit in a Federation: Evaluating Intergovernmental Grants in Brazilian Municipalities
Creators: name: Politi, Ricardo
name: Enlinson Mattos
Publisher: name: SAGE Journals
Year: 2016
Subjects: subject: Economics
subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental Appendix for Wages, Informality, and Net Fiscal Benefit in a Federation: Evaluating Intergovernmental Grants in Brazilian Municipalities by Ricardo Politi and Enlinson Mattos in Public Finance Review
Supplementary document for Propagation-based phase-contrast imaging method for full-field X-ray microscopy using advanced Kirkpatrick–Baez mirrors - 6534483.pdf
Creators: name: Tanaka, Yuto
name: Yamada, Jumpei
name: Inoue, Takato
name: Kimura, Takashi
name: Shimura, Mari
name: Kohmura, Yoshiki
name: Yabashi, Makina
name: Ishikawa, Tetsuya
name: Yamauchi, Kazuto
name: Matsuyama, Satoshi
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplemental material
Supplementary document for Propagation-based phase-contrast imaging method for full-field X-ray microscopy using advanced Kirkpatrick–Baez mirrors - 6534483.pdf
Creators: name: Tanaka, Yuto
name: Yamada, Jumpei
name: Inoue, Takato
name: Kimura, Takashi
name: Shimura, Mari
name: Kohmura, Yoshiki
name: Yabashi, Makina
name: Ishikawa, Tetsuya
name: Yamauchi, Kazuto
name: Matsuyama, Satoshi
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Classical and Physical Optics

description: Supplemental material
title: Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish
Creators: name: Cardeira-Da-Silva, João
name: Wang, Qianchen
name: Sagvekar, Pooja
name: Mintcheva, Janita
name: Latting, Stephan
name: Günther, Stefan
name: Ramadass, Radhan
name: Yekelchyk, Michail
name: Preussner, Jens
name: Looso, Mario
name: Junker, Jan Philipp
name: Stainier, Didier Y. R.
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: Adaptive immunity
subject: Antigen-presenting cells
subject: Developmental biology
subject: Zebrafish
subject: 500 Naturwissenschaften und Mathematik

description: In contrast to adult mammals, adult zebrafish can fully regenerate injured cardiac tissue, and this regeneration process requires an adequate and tightly controlled immune response. However, which components of the immune response are required during regeneration is unclear. Here, we report positive roles for the antigen presentation-adaptive immunity axis during zebrafish cardiac regeneration. We find that following the initial innate immune response, activated endocardial cells (EdCs), as well as immune cells, start expressing antigen presentation genes. We also observe that T helper cells, a.k.a. Cd4 + T cells, lie in close physical proximity to these antigen-presenting EdCs. We targeted Major Histocompatibility Complex (MHC) class II antigen presentation by generating cd74a; cd74b mutants, which display a defective immune response. In these mutants, Cd4 + T cells and activated EdCs fail to efficiently populate the injured tissue and EdC proliferation is significantly decreased. cd74a; cd74b mutants exhibit additional defects in cardiac regeneration including reduced cardiomyocyte dedifferentiation and proliferation. Notably, Cd74 also becomes activated in neonatal mouse EdCs following cardiac injury. Altogether, these findings point to positive roles for antigen presentation during cardiac regeneration, potentially involving interactions between activated EdCs, classical antigen-presenting cells, and Cd4 + T cells.
title: Auswirkungen der konventionellen harnsäuresenkenden Therapie auf Mononatriumuratkristalle bei Gicht-Patienten – eine longitudinale Dual-Energy-CT-Studie
Creators: name: Reiche, Nora
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: Gicht

description: Gicht (Arthritis urica) ist eine rheumatische Erkrankung, die durch Ablagerungen von Harnsäurekristallen in und um Gelenke infolge einer Hyperurikämie entsteht. Weiterhin kommt es zu peri- und intraartikulären Entzündungsreaktionen, welche unbehandelt über einen chronischen entzündlichen Prozess zu erheblichen Einschränkungen der körperlichen Funktionsfähigkeit und somit reduzierter Lebensqualität führen können. Die konventionelle harnsäuresenkende Therapie gegen die Ablagerung von Mononatriumurat (MNU) bei Gichtpatienten ist eine etablierte und evidenzbasierte Therapie. Ihre Langzeitwirkung auf die MNU-Ablagerungen wurde jedoch noch nicht systematisch untersucht, insbesondere nicht unter realen Bedingungen und im Zusammenhang mit anderen therapeutischen Ansätzen zur Senkung der Harnsäure. Ziel dieser Studie war es daher, die Langzeitwirkung einer konventionellen harnsäuresenkenden Therapie auf MNU-Ablagerungen bei Gichtpatienten mittels Dual-Energy-CT (DECT) zu untersuchen.
Supplemental_Materials_(1) – Supplemental material for Cultural Adaptations to the Measurement of Attitudes to Ageing: Psychometric Assessment of the Malay Reactions to Ageing Questionnaire
Creators: name: Faudzi, Farah Nadia M.
name: Armitage, Christopher J.
name: Bryant, Christina
name: Brown, Laura J. E.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Supplemental_Materials_(1) for Cultural Adaptations to the Measurement of Attitudes to Ageing: Psychometric Assessment of the Malay Reactions to Ageing Questionnaire by Farah Nadia M. Faudzi, Christopher J. Armitage, Christina Bryant, and Laura J. E. Brown in Assessment
title: Epilepsie nach intrazerebraler Blutung: Inzidenz, Charakterisierung und Risikofaktoren
Creators: name: Steidl, Josephine
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: Epilepsie
subject: Schlaganfall
subject: intrazerebrale Blutung

description: Die Entwicklung einer Epilepsie ist eine häufige Langzeitkomplikation nach einem „Schlaganfall“. Welche Patienten dafür besonders gefährdet sind, ist aktuell noch nicht geklärt. In bisherigen Studien wurden vor allem Patienten mit Ischämien betrachtet, die Datenlage zu intrazerebralen Blutungen (ICBs) ist lückenhaft. Scores, die Risikofaktoren für die Entwicklung einer Epilepsie nach ICB zusammenfassen existieren zwar in der Literatur, haben sich aber in der Praxis noch nicht durchgesetzt. Insbesondere ist die Rolle der operativen Hämatomevakuation weiterhin unklar. Ziel dieser retrospektiven Studie war es, die Risikofaktoren für die Entwicklung einer Epilepsie nach ICB zu identifizieren und diese Epilepsie zu charakterisieren.
Biomarker Discovery And Sample Stratification: A Case Study
Creators: name: N. Goffard
Publisher: name: Zenodo
Year: 2016

description: Using sequence data to drive the development of a potential targeted therapy is a goal of many pharmaceutical and biotechnology organisations. It requires the ability to combine clinical and genomics data across subject cohorts and correlate biomarkers with phenotypes. Getting the most out of this data can be difficult and time consuming but Illumina provides two software platforms to overcome these challenges; BaseSpace? Correlation Engine and BaseSpace? Cohort Analyzer. These platforms provide a way to easily organise data and apply novel ways to analyse and interpret data across the entire drug discovery and development process from biomarker discovery and translational research to clinical trials.
Supplementary Material, TIPA_Supplementary_Figures_Revised – Tau-independent Phase Analysis: A Novel Method for Accurately Determining Phase Shifts
Creators: name: Tackenberg, Michael C.
name: Jones, Jeff R.
name: Page, Terry L.
name: Hughey, Jacob J.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplementary Material, TIPA_Supplementary_Figures_Revised for Tau-independent Phase Analysis: A Novel Method for Accurately Determining Phase Shifts by Michael C. Tackenberg, Jeff R. Jones, Terry L. Page and Jacob J. Hughey in Journal of Biological Rhythms
Supplementary_Appendix - A Systematic Review of Intimate Partner Violence Interventions: State of the Field and Implications for Practitioners
Creators: name: Trabold, Nicole
name: McMahon, James
name: Alsobrooks, Shannon
name: Whitney, Staci
name: Mittal, Mona
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplementary_Appendix for A Systematic Review of Intimate Partner Violence Interventions: State of the Field and Implications for Practitioners by Nicole Trabold, James McMahon, Shannon Alsobrooks, Staci Whitney, and Mona Mittal in Trauma, Violence, & Abuse
Supplemental Material, Supplementary_Figures - Patient Experience of Recovery After Major Leg Amputation for Arterial Disease
Creators: name: Columbo, Jesse A.
name: Davies, Louise
name: Kang, Ravinder
name: J. Aaron Barnes
name: Leinweber, Kathleen A.
name: Bjoern D. Suckow
name: Goodney, Philip P.
name: Stone, David H.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Cardiology
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental Material, Supplementary_Figures for Patient Experience of Recovery After Major Leg Amputation for Arterial Disease by Jesse A. Columbo, Louise Davies, Ravinder Kang, J. Aaron Barnes, Kathleen A. Leinweber, Bjoern D. Suckow, Philip P. Goodney, and David H. Stone in Vascular and Endovascular Surgery
The Confo?Body Technology, A New Platform To Enable Fragment Screening On Gpcrs
Creators: name: C. Menet
Publisher: name: Zenodo
Year: 2016

description: In the past 10 years, GPCR drug discovery has relied on cell-based assays combined with high-throughput screening (HTS) of large compound libraries for hit discovery. However, progress in identifying new small molecule drugs has been difficult and disappointing especially for GPCR agonists. One key problem is that compounds do not only need to bind to the GPCR, but they must also exhibit the appropriate efficacy profile: agonist, partial agonist, neutral antagonist or inverse agonist. It also well known that a subtle change on the decoration of the ligand can impact its efficacy profile and act on a different signalling pathway of the GPCR.
In past years, Jan Steyaert's lab has shown that Confo?bodies, small (15 kDa) and stable single domain fragments harbouring full antigen-binding capacity, recognize discontinuous amino acid segments on native proteins, making them ideal tools to selectively stabilize specific conformational states of (membrane) proteins.
Confo Therapeutics' approach, based on this technology, is developing a Confo?body-enabled drug discovery platform to explore new chemical space for the development of new drugs targeting GPCRs. Confo? bodies enable screening of a moderate sized fragment library leading to the discovery of new chemical entities presenting several advantages:
Identification of a structurally diverse set of conformational-selective compoundsIdentification of differentiating chemical matter that is not identified by conventional screening technologiesImmediate functional profiling and potency ranking of all hits in a single assay to understand the SARs and to guide the medicinal chemistryIdentification of compounds with significantly higher ligand efficiencyScreening of orthosteric or allosteric ligandsContrary to e.g. cell-based screening assays, fewer false positives/negatives caused by off-target effects. This is especially relevant for screening at high ligand concentrations that are toxic for the cell.
Targeting Cd47 In Cancer With Bispecific Antibodies
Creators: name: K. Masternak
Publisher: name: Zenodo
Year: 2016

description: CD47 is a ubiquitous immune checkpoint receptor overexpressed in cancer. Upregulation of CD47 plays a key role in immune evasion and correlates with poor clinical prognosis. CD47 interacts with SIRP-alpha on macrophages and other myeloid cells conveying a 'don't eat me' signal which inhibits phagocytosis of tumor cells. While monoclonal antibodies (mAbs) inhibiting CD47 boost tumor destruction by enhancing the killing potential of macrophages, the widespread tissue distribution of CD47 makes their clinical development challenging.
To circumvent tolerability and antigen sink problems arising from ubiquitous expression of CD47, we generated dual-targeting bispecific antibodies (biAbs) allowing selective blockade of CD47 on malignant cells expressing a tumor-associated antigen (TAA), CD19 or mesothelin. These bispecific kappa-lambda bodies pair a high affinity anti-TAA arm with a CD47 targeting arm and are structurally identical to human IgG1. As such, they combine efficient tumor cell targeting and selective CD47 blockage with immune activating mechanisms mediated by IgG1 constant Fc portion. We show that these biAbs are able to selectively kill cancer cells through ADCP (antibody-dependent cellular phagocytosis) and antibody-dependent cell-mediated cytotoxicity (ADCC). Potent anti-tumor activity as either monotherapy or in combination was also demonstrated in vivo, in experiments using human cancer cell lines and patient-derived xenografts.
Dual targeting anti-CD47/TAA biAbs interact weakly with normal healthy cells expressing physiological levels of CD47. In vitro safety studies demonstrate a minimal binding to human erythrocytes, platelets or T cells, and no evidence of platelet activation at the anticipated therapeutic concentrations. Pharmacokinetic and safety studies performed with NI-1701 in non-human primates (NHP) demonstrate long half-life and no effects on hematological parameters (e.g., red blood cell and platelet counts) up to 100mg/kg, the highest dose tested. Importantly, we also demonstrate that, contrary to anti-CD47 mAbs, dual targeting CD47 neutralizing biAbs preserve their tumoricidal efficacy in the presence of bystander CD47-positive cells. As a corollary, we show that dual targeting biAbs allow an efficacious yet safe targeting of CD47 in cancer. Dual targeting bispecific antibody approach could potentially be applied to limit the extent of therapeutic neutralization of other ubiquitously expressed antibody targets.
cre-2017-6705-File001 – Supplemental material for What influences decisions about ongoing stroke rehabilitation for patients with pre-existing dementia or cognitive impairment: a qualitative study?
Creators: name: Longley, Verity
name: Peters, Sarah
name: Swarbrick, Caroline
name: Bowen, Audrey
Publisher: name: Figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110904 Neurology and Neuromuscular Diseases

description: Supplemental material, cre-2017-6705-File001 for What influences decisions about ongoing stroke rehabilitation for patients with pre-existing dementia or cognitive impairment: a qualitative study? by Verity Longley, Sarah Peters, Caroline Swarbrick and Audrey Bowen in Clinical Rehabilitation
Supplementary Tables -Supplemental material for Factors associated to chronic migraine with medication overuse: A cross-sectional study
Creators: name: Viana, Michele
name: Bottiroli, Sara
name: Sances, Grazia
name: Ghiotto, Natascia
name: Allena, Marta
name: Guaschino, Elena
name: Nappi, Giuseppe
name: Tassorelli, Cristina
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary Tables for Factors associated to chronic migraine with medication overuse: A cross-sectional study by Michele Viana, Sara Bottiroli, Grazia Sances, Natascia Ghiotto, Marta Allena, Elena Guaschino, Giuseppe Nappi and Cristina Tassorelli in Cephalalgia
HopmanOpenPracticesDisclosure – Supplemental material for Production Practice During Language Learning Improves Comprehension
Creators: name: Hopman, Elise W. M.
name: MacDonald, Maryellen C.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Neuroscience
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, HopmanOpenPracticesDisclosure for Production Practice During Language Learning Improves Comprehension by Elise W. M. Hopman and Maryellen C. MacDonald in Psychological Science
Supplement_figure - A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green–Labeled Podoplanin Antibody
Creators: name: Ito, Akihiro
name: Ohta, Mitsuhiko
name: Kato, Yukinari
name: Shunko Inada
name: Kato, Toshio
name: Nakata, Susumu
name: Yatabe, Yasushi
name: Goto, Mitsuo
name: Kaneda, Norio
name: Kurita, Kenichi
name: Hayao Nakanishi
name: Yoshida, Kenji
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Biochemistry
subject: 110320 Radiology and Organ Imaging
subject: FOS: Clinical medicine
subject: 111299 Oncology and Carcinogenesis not elsewhere classified

description: Supplement_figure for A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green–Labeled Podoplanin Antibody by Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato, Susumu Nakata, Yasushi Yatabe, Mitsuo Goto, Norio Kaneda, Kenichi Kurita, Hayao Nakanishi, and Kenji Yoshida in Technology in Cancer Research & Treatment
Online_Appendix_CGB_Scale – Supplemental material for The Role of Compensatory Beliefs in Rationalizing Environmentally Detrimental Behaviors
Creators: name: Hope, Aimie L. B.
name: Jones, Christopher R.
name: Webb, Thomas L.
name: Watson, Matthew T.
name: Kaklamanou, Daphne
Publisher: name: SAGE Journals
Year: 2017
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Online_Appendix_CGB_Scale for The Role of Compensatory Beliefs in Rationalizing Environmentally Detrimental Behaviors by Aimie L. B. Hope, Christopher R. Jones, Thomas L. Webb, Matthew T. Watson and Daphne Kaklamanou in Environment and Behavior
Supplementary_data - The effect of polyurethane and carnauba wax on the mechanical and physicochemical properties of acrylonitrile butadiene nitrile rubber coating working gloves
Creators: name: Düşünceli, Necmi
name: Akyüz, Lalehan
name: Şahin, Necmettin
name: Duru, Hatice
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental Material, supplementary_data for The effect of polyurethane and carnauba wax on the mechanical and physicochemical properties of acrylonitrile butadiene nitrile rubber coating working gloves by Necmi Düşünceli, Lalehan Akyüz, Necmettin Şahin, and Hatice Duru in Journal of Elastomers & Plastics
Supplemental material for Attitudes of people working in mental health non-governmental organisations in Australia: A comparison with other mental health professionals
Creators: name: Grenville Rose
name: Hippel, Courtney Von
name: Brener, Loren
name: Hippel, Bill Von
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplemental_material for Attitudes of people working in mental health non-governmental organisations in Australia: A comparison with other mental health professionals by Grenville Rose, Courtney von Hippel, Loren Brener and Bill von Hippel in Health Psychology Open
title: Tracking the Black Diaspora along the U.S. Gulf Coast during Slavery: Texas and New Orleans
Creators: name: Weeks, Sean
Publisher: name: Rice University
publisherIdentifier: https://ror.org/008zs3103
publisherIdentifierScheme: ROR
Year: 2025

description: The SlaveVoyages.org project has continued to make available records on the traffic of enslaved people to the Americas, especially in the intra-American traffic. Recently, we have focused on pairing images of manifests of the slave voyages with voyage IDs in our database so that the public will be able to easily access the images for their own research. We also aim to strengthen the credibility of our database entries by making our sources clearly available.
Supplemental Material, Seasonal_Differences_in_Light_Exposure_and_the_Assocaitoins_with_Health - Seasonal Differences in Light Exposure and the Associations With Health and Well-Being in Older Adults: An Exploratory Study
Creators: name: Nioi, Amanda
name: Roe, Jenny
name: Gow, Alan
name: McNair, David
name: Aspinall, Peter
Publisher: name: SAGE Journals
Year: 2017
Subjects: subject: Medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, Seasonal_Differences_in_Light_Exposure_and_the_Assocaitoins_with_Health for Seasonal Differences in Light Exposure and the Associations With Health and Well-Being in Older Adults: An Exploratory Study by Amanda Nioi, Jenny Roe, Alan Gow, David McNair, Peter Aspinall in HERD: Health Environments Research & Design Journal
FigureS2 ScenarioC -Supplemental material for A two-stage approach to estimate spatial and spatio-temporal disease risks in the presence of local discontinuities and clusters
Creators: name: A Adin
name: D Lee
name: T Goicoa
name: Ugarte, María Dolores
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111708 Health and Community Services
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, FigureS2 ScenarioC for A two-stage approach to estimate spatial and spatio-temporal disease risks in the presence of local discontinuities and clusters by A Adin, D Lee, T Goicoa and María Dolores Ugarte in Statistical Methods in Medical Research
Common Themes In The Evolution Of Drug Resistance
Creators: name: S. Bonhoeffer
Publisher: name: Zenodo
Year: 2016

description: Novel Approaches to antibacterial Discovery and Development
Today the problems caused by antimicrobial resistance (AMR) that lead to annually 700'000 deaths have been recognized globally. The challenges that need to be considered are many: the quest for new antibiotics devoid of cross-resistance, antibiotic stewardship including reduction of inappropriate use, deployment of point-of-care rapid diagnostics, development of streamlined regulatory pathways and finding sustainable financing models. Considering innovative approaches to tackle AMR, there has also been renewed interest in the discovery of narrow-spectrum antibiotics and alternative therapies to complement the pipeline and reduce the dependence on antimicrobials. These include phage therapy , approaches to target persisters or inhibitors acting on pathways that are only essential for bacterial pathogen survival in the host. Development strategies including drug combination regimen will also be discussed. Importantly, these approaches will be considered in the context of the need to find new global business models for antibiotics.
Salmonella Single-Cell Dynamics In Complex Tissues
Creators: name: D. Bumann
Publisher: name: Zenodo
Year: 2016

description: During infections, host-pathogen interactions occur in complex, dynamically changing host tissues. Our work in a mouse Salmonella infection model shows that pathogen subsets reside in diverse host microenvironments, where they have differential access to host nutrients and disparate exposures to nitric oxide, reactive oxygen species, and drugs. FACSorting and proteome analysis of Salmonella subsets reveal distinct local adaptations involving just a few, or up to hundreds of proteins. During treatment with antibiotics, the various Salmonella subsets differ in their survival with both synergistic and antagonistic interactions between immune effectors and antibiotics. These results show that this salmonellosis consists of strikingly heterogeneous and dynamic Salmonella-host encounters involving diverse tissue regions, cell types, and molecular mechanisms. Overall disease progression results from failures in host control or antibiotic therapy at some tissue sites, despite successful simultaneous eradication in others. Disparate Salmonella-host encounters thus make the difference between lethal disease and successful control.
In the half-light and shadows: criminal deportation from the state of refuge under refugee and human rights law : with special reference to the United States and subsidiary examination of the Federal Republic of Germany
Creators: name: Ni Mhuircheartaigh, Nuala
Publisher: name: My University
Year: 2000
Subjects: human rights
refugee law
Germany
United States of America

description: Second semester University: Abo Akademi University
Discovery And Development Of Novel Macrocycle Antibiotics
Creators: name: G. Dale
Publisher: name: Zenodo
Year: 2016

description: Murapavadin (POL7080) is the frontrunner of a new class of novel cyclopeptides antibiotic discovered by Polyphor, with a novel mode of action that targets the beta-barrel outer membrane protein LptD of Pseudomonas bacteria, causing disruption to bacterial processes necessary for the outer membrane lipopolysaccharide biogenesis (Science, 2010, 327, 1010-1013, DOI). This Pseudomonas specific antibiotic is highly active on a broad panel of clinical isolates including multi-drug resistant (MDR) strains and colistin-resistant isolates, with an MIC90 = 0.25 ?g/mL against Pseudomonas aeruginosa. A Phase I clinical trial in healthy volunteers in Europe was successfully completed demonstrating the clinical safety and tolerability of POL7080 and a Phase II study is on-going in ventilator-associated pneumonia (VAP). Furthermore, Polyphor is developing a novel class of broad-spectrum Gram-negative antibiotics, which have promising in vivo POC data showing that these new compound series targets MDR Gram-negative ESKAPE pathogens. Polyphor's antibiotic programs are derived from our macrocycle technology platform and our major R&D efforts focus on diseases with high unmet medical need in the hospital care sector and lung diseases.
The Asset-Centric Business Model: The Established Trend In Venture Capital Investing
Creators: name: M. De Boer
Publisher: name: Zenodo
Year: 2016

description: Advances in genomics and proteomics, completion of the human genome, creation of bio banks, new scientific insights and development of targeted diagnostics and therapeutics have created tremendous opportunities for new companies to emerge. Nurturing these start-up takes great care and the right sustenance. The challenge for the founders are always ever-changing, some of the biggest hurdles beings setting-up up the company and acquiring the financing required to take a promising innovation all the way to the finish line.
The Jumpstarting Innovation Forum will be an engaging two-day session on the role of early stage investing, innovative models of funding and incubation, with a range of international speakers, from biotech companies and incubators to some of the top tier venture funds in this area as well as some of the leading pharma companies.
Supplementary_Data_Sheet_1 – Supplemental material for Cross-Cultural Aspects: Exploring Motor Competence Among 7- to 8-Year-Old Children From Greece, Italy, and Norway
Creators: name: Haga, Monika
name: Tortella, Patrizia
name: Asonitou, Katerina
name: Charitou, Sophia
name: Koutsouki, Dimitra
name: Fumagalli, Guido
name: Sigmundsson, Hermundur
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, Supplementary_Data_Sheet_1 for Cross-Cultural Aspects: Exploring Motor Competence Among 7- to 8-Year-Old Children From Greece, Italy, and Norway by Monika Haga, Patrizia Tortella, Katerina Asonitou, Sophia Charitou, Dimitra Koutsouki, Guido Fumagalli and Hermundur Sigmundsson in SAGE Open
Measurements of body lengths, circumferences, and amplitudes as predictive indicators of cardio respiratory efficiency: An analytical study on young soccer players
Creators: name: دحماني موسى عبد الكريم
name: بردي طه إلياس
name: بنور معمر
Publisher: name: Zenodo
Year: 2025
Subjects: Anthropometric Measurements ; Cardio-Respiratory Fitness ; Soccer

description: The Object of the study aims to identify the relationship between some anthropometric measurements and the cardiorespiratory system of young soccer players, for this purpose, we used the method Descriptive approach On a sample composed of 30 Players Chosen as Deliberately, and for data collection, we used a tool Physical measurements and a 20-m MRST After collecting the results, we conclude There was a strong correlation between (body length, lower extremity; leg, thigh, and chest circumference; chest width, wrist and shoulder width) and MAS& Vo2max.
'Living drugs' target CD70 in advanced renal tumors
Creators: name: Wagner, Kilian
name: Siska, Peter J.
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: CAR T cells, kidney cancer, renal cell carcinoma, allogeneic, CD70, VHL
subject: 610 Medizin

description: Cellular therapies against solid tumors face three major barriers: low persistence, insufficient specificity, and high costs. In a recent study, Pal et al. tackle these challenges in kidney cancer by using novel, 'persistence-tuned' allogeneic chimeric antigen receptor (CAR) T cells directed against a stable antigen.
DS_10.1177_0272989X18763802 – Supplemental material for A Personalized Approach of Patient–Health Care Provider Communication Regarding Colorectal Cancer Screening Options
Creators: name: M. Gabriela Sava
name: Dolan, James G.
name: May, Jerrold H.
name: Vargas, Luis G.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, DS_10.1177_0272989X18763802 for A Personalized Approach of Patient–Health Care Provider Communication Regarding Colorectal Cancer Screening Options by M. Gabriela Sava, James G. Dolan, Jerrold H. May, and Luis G. Vargas in Medical Decision Making
Company Creation: Innovation In Financing & Development
Creators: name: R. Droller
Publisher: name: Zenodo
Year: 2016

description: Advances in genomics and proteomics, completion of the human genome, creation of bio banks, new scientific insights and development of targeted diagnostics and therapeutics have created tremendous opportunities for new companies to emerge. Nurturing these start-up takes great care and the right sustenance. The challenge for the founders are always ever-changing, some of the biggest hurdles beings setting-up up the company and acquiring the financing required to take a promising innovation all the way to the finish line.
The Jumpstarting Innovation Forum will be an engaging two-day session on the role of early stage investing, innovative models of funding and incubation, with a range of international speakers, from biotech companies and incubators to some of the top tier venture funds in this area as well as some of the leading pharma companies.
Supplementary document for Light Triggered 2D Electron Gas in GaN based HEMT with Sandwiched p-GaN Layers - 6535455.pdf
Creators: name: Wang, Yu
name: Liu, Chuankai
name: Qian, Hao
name: Liu, Hangzan
name: Han, Lixiang
name: Gao, Wei
name: Wang, Xiaozhou
name: Li, Jingbo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Novel Ways For Innovators To Work Collaboratively With The Health Innovation Ecosystem. The Mars / Canada Story
Creators: name: Z. Khayat
Publisher: name: Zenodo
Year: 2016

description: Advances in genomics and proteomics, completion of the human genome, creation of bio banks, new scientific insights and development of targeted diagnostics and therapeutics have created tremendous opportunities for new companies to emerge. Nurturing these start-up takes great care and the right sustenance. The challenge for the founders are always ever-changing, some of the biggest hurdles beings setting-up up the company and acquiring the financing required to take a promising innovation all the way to the finish line.
The Jumpstarting Innovation Forum will be an engaging two-day session on the role of early stage investing, innovative models of funding and incubation, with a range of international speakers, from biotech companies and incubators to some of the top tier venture funds in this area as well as some of the leading pharma companies.
What Does It Take To Be Innovative In Pharma?
Creators: name: O. Krylova
Publisher: name: Zenodo
Year: 2016

description: Advances in genomics and proteomics, completion of the human genome, creation of bio banks, new scientific insights and development of targeted diagnostics and therapeutics have created tremendous opportunities for new companies to emerge. Nurturing these start-up takes great care and the right sustenance. The challenge for the founders are always ever-changing, some of the biggest hurdles beings setting-up up the company and acquiring the financing required to take a promising innovation all the way to the finish line.
The Jumpstarting Innovation Forum will be an engaging two-day session on the role of early stage investing, innovative models of funding and incubation, with a range of international speakers, from biotech companies and incubators to some of the top tier venture funds in this area as well as some of the leading pharma companies.
Elthera: A Novel Approach For Targeted Cancer Therapy
Creators: name: A. Schmidt
Publisher: name: Zenodo
Year: 2016

description: Advances in genomics and proteomics, completion of the human genome, creation of bio banks, new scientific insights and development of targeted diagnostics and therapeutics have created tremendous opportunities for new companies to emerge. Nurturing these start-up takes great care and the right sustenance. The challenge for the founders are always ever-changing, some of the biggest hurdles beings setting-up up the company and acquiring the financing required to take a promising innovation all the way to the finish line.
The Jumpstarting Innovation Forum will be an engaging two-day session on the role of early stage investing, innovative models of funding and incubation, with a range of international speakers, from biotech companies and incubators to some of the top tier venture funds in this area as well as some of the leading pharma companies.
Introduction By Baselarea.Swiss
Creators: name: S. Emmerth
Publisher: name: Zenodo
Year: 2016

description: Advances in genomics and proteomics, completion of the human genome, creation of bio banks, new scientific insights and development of targeted diagnostics and therapeutics have created tremendous opportunities for new companies to emerge. Nurturing these start-up takes great care and the right sustenance. The challenge for the founders are always ever-changing, some of the biggest hurdles beings setting-up up the company and acquiring the financing required to take a promising innovation all the way to the finish line.
The Jumpstarting Innovation Forum will be an engaging two-day session on the role of early stage investing, innovative models of funding and incubation, with a range of international speakers, from biotech companies and incubators to some of the top tier venture funds in this area as well as some of the leading pharma companies.
SUDLАR TОMОNIDАN KОRPОRАTIV NIZОLАRNI HАL ЕTISHNI TАKОMILLАSHTIRISH MАSАLАLАRI
Creators: name: Xаzrаtqulоvа, Jаsminа
Publisher: name: Zenodo
Year: 2025

description: Ushbu tеzisdа kоrpоrаtiv nizоlаrni hаl еtish mаsаlаlаri yuzаsidаn qоnunchilik nоrmаlаri qiyоsiy tаhlil qilinib, kоrpоrаtiv huquqiy munоsаbаtlаrni tаrtibgа sоluvchi mоddiy vа prоtsеssuаl huquq nоrmаlаrini qо‘llаsh bilаn bоg‘liq sud аmаliyоtini birxillаshtirish, ishlаrni kо‘rishdа yuzаgа kеlаyоtgаn bо’shliqlаr, xаtоliklаrni bаrtаrаf еtish mаsаlаlаrning qоnuniy yеchimini tоpishgа yо‘nаltirilgаn tаklif vа tаvsiyаlаr  bаyоn еtilаdi.
Supplemental material for An omnibus test for the global null hypothesis
Creators: name: Futschik, Andreas
name: Taus, Thomas
name: Zehetmayer, Sonja
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111708 Health and Community Services
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material for An omnibus test for the global null hypothesis by Andreas Futschik, Thomas Taus and Sonja Zehetmayer: R Core Team in Statistical Methods in Medical Research
Oxytocin Mimetics
Creators: name: P. Alewood
Publisher: name: Zenodo
Year: 2016

description: Poor oral availability and susceptibility to reduction and protease degradation is a major hurdle in peptide drug development for peripheral or central nervous system candidates. In contrast, druggable receptors in the gut present an attractive niche for peptide therapeutics. Here we demonstrate, in a mouse model of chronic abdominal pain, that oxytocin receptors are significantly upregulated in nociceptors innervating the colon. Correspondingly, we have developed novel chemoselective strategies to engineer non-reducible stable oxytocin analogues that are equipotent to native oxytocin. Moreover, we describe single atom modifications to oxytocin disulfide bridges produce ligands with improved selectivity across species. Nuclear magnetic resonance structural analysis of native oxytocin and the seleno-oxytocin derivatives reveals that oxytocin has a pre-organized turn structure in solution, in marked contrast to earlier X-ray crystallography studies. These seleno-oxytocin analogues potently inhibit colonic nociceptors both in vitro and in vivo in mice with chronic visceral hypersensitivity. Our findings have important implications for the clinical use of oxytocin analogues and disulfide-rich peptides in general.