cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Principled Design of Image Representation: Towards Forensic Tasks
Creators: name: Qi, Shuren
name: Zhang, Yushu
name: Wang, Chao
name: Zhou, Jiantao
name: Cao, Xiaochun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Image forensics is a rising topic as the trustworthy multimedia content is critical for modern society. Like other vision-related applications, forensic analysis relies heavily on the proper image representation. Despite the importance, current theoretical understanding for such representation remains limited, with varying degrees of neglect for its key role. For this gap, we attempt to investigate the forensic-oriented image representation as a distinct problem, from the perspectives of theory, implementation, and application. Our work starts from the abstraction of basic principles that the representation for forensics should satisfy, especially revealing the criticality of robustness, interpretability, and coverage. At the theoretical level, we propose a new representation framework for forensics, called Dense Invariant Representation (DIR), which is characterized by stable description with mathematical guarantees. At the implementation level, the discrete calculation problems of DIR are discussed, and the corresponding accurate and fast solutions are designed with generic nature and constant complexity. We demonstrate the above arguments on the dense-domain pattern detection and matching experiments, providing comparison results with state-of-the-art descriptors. Also, at the application level, the proposed DIR is initially explored in passive and active forensics, namely copy-move forgery detection and perceptual hashing, exhibiting the benefits in fulfilling the requirements of such forensic tasks.
description: Accepted by IEEE Transactions on Pattern Analysis and Machine Intelligence, 2022, https://ieeexplore.ieee.org/document/9881995/
The Association between Risk Management Committee and Stock Investment Risk
Creators: name: Panya Issarawornrawanich
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: Risk Management Committee
Stock Investment Risk
Idiosyncratic Risk
Corporate Governance

description: วารสารบริหารธุรกิจ JBA, 41, 160 (ต.ค.-ธ.ค. 61), 47
Association between Board Composition and Intellectual Capital Disclosure: An Evidence from Thailand
Creators: name: Muttanachai Suttipun
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: Board Composition
Intellectual Capital Disclosure
Thailand

description: วารสารบริหารธุรกิจ JBA, 41, 160 (ต.ค.-ธ.ค. 61), 74
Platform Revolution
Creators: name: นภดล ร่มโพธิ์
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: n/a

description: วารสารบริหารธุรกิจ JBA, 41, 160 (ต.ค.-ธ.ค. 61), 98
Deep Rectangling for Image Stitching: A Learning Baseline
Creators: name: Nie, Lang
name: Lin, Chunyu
name: Liao, Kang
name: Liu, Shuaicheng
name: Zhao, Yao
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Stitched images provide a wide field-of-view (FoV) but suffer from unpleasant irregular boundaries. To deal with this problem, existing image rectangling methods devote to searching an initial mesh and optimizing a target mesh to form the mesh deformation in two stages. Then rectangular images can be generated by warping stitched images. However, these solutions only work for images with rich linear structures, leading to noticeable distortions for portraits and landscapes with non-linear objects. In this paper, we address these issues by proposing the first deep learning solution to image rectangling. Concretely, we predefine a rigid target mesh and only estimate an initial mesh to form the mesh deformation, contributing to a compact one-stage solution. The initial mesh is predicted using a fully convolutional network with a residual progressive regression strategy. To obtain results with high content fidelity, a comprehensive objective function is proposed to simultaneously encourage the boundary rectangular, mesh shape-preserving, and content perceptually natural. Besides, we build the first image stitching rectangling dataset with a large diversity in irregular boundaries and scenes. Experiments demonstrate our superiority over traditional methods both quantitatively and qualitatively.
description: Accepted by CVPR2022 (oral); Codes and dataset: https://github.com/nie-lang/DeepRectangling
Assessing the calibration in toxicological in vitro models with conformal prediction
Creators: name: Morger, Andrea
name: Svensson, Fredrik
name: Arvidsson McShane, Staffan
name: Gauraha, Niharika
name: Norinder, Ulf
name: Spjuth, Ola
name: Volkamer, Andrea
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Toxicity prediction
subject: Conformal prediction
subject: Data drifts
subject: Applicability domain
subject: Calibration plots
subject: Tox21 datasets
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Machine learning methods are widely used in drug discovery and toxicity prediction. While showing overall good performance in cross-validation studies, their predictive power (often) drops in cases where the query samples have drifted from the training data's descriptor space. Thus, the assumption for applying machine learning algorithms, that training and test data stem from the same distribution, might not always be fulfilled. In this work, conformal prediction is used to assess the calibration of the models. Deviations from the expected error may indicate that training and test data originate from different distributions. Exemplified on the Tox21 datasets, composed of chronologically released Tox21Train, Tox21Test and Tox21Score subsets, we observed that while internally valid models could be trained using cross-validation on Tox21Train, predictions on the external Tox21Score data resulted in higher error rates than expected. To improve the prediction on the external sets, a strategy exchanging the calibration set with more recent data, such as Tox21Test, has successfully been introduced. We conclude that conformal prediction can be used to diagnose data drifts and other issues related to model calibration. The proposed improvement strategy-exchanging the calibration data only-is convenient as it does not require retraining of the underlying model.
Aphonie bei multipler Sklerose = Aphonia Multiple Sclerosis
Creators: name: Haferkamp, G.
name: Hacki, Tamas
name: Hofmann, R.
name: Kenklies, M.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin

description: This is a report on a female patient suffering from slowly progressive multiple sclerosis. Soon after onset of the disease, hoarseness became manifest and lasted for six years, climaxing in aphonia. Treatment with L-dopa medication was successful. The patient regained her voice.
Entropy current and equilibrium partition function in fluid dynamics
Creators: name: Bhattacharyya, Sayantani
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Existence of an entropy current with non-negative divergence puts a lot of constraints on the transport coefficients of a fluid, so does the existence of equilibrium. In all the cases we have studied so far we have seen an overlap between these two sets of constraints. In this note we shall try to explore the reason for such an overlap. We shall also see how a part of the entropy current could be determined from the equilibrium partition function.
description: 39 pages, Version-2: Added a new section and some more arguments in the old sections, added new references and corrected typos. 45 pages Version 3: 50 pages, introduction has been modified, added a new section, added references
Onboarding snakemake: Progress towards WfExS-backend integration
Creators: name: Iborra, Paula
name: Fernández, José M.
name: Capella-Gutierrez, Salvador
Publisher: name: F1000 Research Limited
Year: 2024

description: Workflow Execution Service Backend (WfExS-backend) is a high-level workflow orchestrator designed for reproducible and secure workflow executions in isolated environments, promoting analysis reproducibility and replicability using potentially sensitive data. Through a user-friendly command line interface, WfExS fetches and materialises all necessary elements for workflow instantiation, including publicly available workflows, workflow engines, software containers, and reachable inputs, identified via URLs or stable permanent identifiers (CURIEs).

Currently, WfExS exclusively supports both Nextflow and cwltool engines, so it is restricted to workflows written in Nextflow or CWL. There is an ongoing effort to integrate snakemake engine, in order to support snakemake workflows. However, integrating a new workflow engine poses multifaceted challenges. Ensuring compatibility with existing infrastructure, encompassing language syntax, containerization strategies, and execution models, is paramount.  Furthermore, Snakemake workflows introspection, incorporating their modular structure, available wrappers and subworkflows, presents a significant hurdle, while preserving overall workflow coherence. Validating consistency and reproducibility adds another layer of complexity to the integration process, requiring meticulous testing and verification procedures to ensure consistent and reliable workflow outcomes across multiple executions. Nevertheless, comprehensive documentation and community support streamline the integration process.

Successfully incorporating Snakemake into WfExS-backend expands the software versatility and utility for scientific communities relying on this workflow engine, thereby advancing its mission of promoting analysis reproducibility and replicability across different workflows engines and scientific ecosystems in secure environments.
KPE: Keypoint Pose Encoding for Transformer-based Image Generation
Creators: name: Cheong, Soon Yau
name: Mustafa, Armin
name: Gilbert, Andrew
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Transformers have recently been shown to generate high quality images from text input. However, the existing method of pose conditioning using skeleton image tokens is computationally inefficient and generate low quality images. Therefore we propose a new method; Keypoint Pose Encoding (KPE); KPE is 10 times more memory efficient and over 73% faster at generating high quality images from text input conditioned on the pose. The pose constraint improves the image quality and reduces errors on body extremities such as arms and legs. The additional benefits include invariance to changes in the target image domain and image resolution, making it easily scalable to higher resolution images. We demonstrate the versatility of KPE by generating photorealistic multiperson images derived from the DeepFashion dataset. We also introduce a evaluation method People Count Error (PCE) that is effective in detecting error in generated human images.
The characteristic polynomial of the Adams operators on graded connected Hopf algebras
Creators: name: Aguiar, Marcelo
name: Lauve, Aaron
Publisher: name: arXiv
Year: 2014
Subjects: subject: Rings and Algebras (math.RA)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 16T05, 16T30

description: The Adams operators $Ψ_n$ on a Hopf algebra $H$ are the convolution powers of the identity of $H$. We study the Adams operators when $H$ is graded connected. They are also called Hopf powers or Sweedler powers. The main result is a complete description of the characteristic polynomial (both eigenvalues and their multiplicities) for the action of the operator $Ψ_n$ on each homogeneous component of $H$. The eigenvalues are powers of $n$. The multiplicities are independent of $n$, and in fact only depend on the dimension sequence of $H$. These results apply in particular to the antipode of $H$ (the case $n=-1$). We obtain closed forms for the generating function of the sequence of traces of the Adams operators. In the case of the antipode, the generating function bears a particularly simple relationship to the one for the dimension sequence. In case H is cofree, we give an alternative description for the characteristic polynomial and the trace of the antipode in terms of certain palindromic words. We discuss parallel results that hold for Hopf monoids in species and $q$-Hopf algebras.
description: 36 pages; two appendices
title: Verfremdungen/Aneignungen: Zum Amerikanismus im sowjetischen Film der zwanziger und dreißiger Jahre
Creators: name: Hänsgen, Sabine
Publisher: name: Fachinformationsdienst Slavistik
Year: 1999
Subjects: subject: Aleksandrov, Grigorij V.
subject: Kulešov, Lev V.
subject: Sowjetunion
subject: USA
subject: Filmanalyse
subject: Kulturelle Aneignung
subject: 491.8

description: Die semiotische Forschung der Moskau-Tartuer Schule betrachtet den semantischen Binarismus von eigen versus fremd als Triebkraft für die Dynamik kultureller Prozesse. Basierend auf dieser Grundthese werden in der vorliegenden Analyse zwei bekannte sowjetische Filmkomödien untersucht: Ley Kulesovs "Die ungewöhnlichen Abenteuer des Mister Vest im Land der Bol'seviki" (1924) und Grigorij Aleksandrovs "Zirkus" (1936). Dabei liegt der Fokus insbesondere auf der Übertragung amerikanischer Filmmuster in die sowjetische Kultur.
description: Kultur als Übersetzung: Festschrift für Klaus Städtke zum 65. Geburtstag, p. 203
Transformationspfade für eine Kultur der Nachhaltigkeit an deutschen Hochschulen
Creators: name: Fritz, Hilke
name: Holst, Jorrit
name: Lang, Daniel J.
name: Nölting, Benjamin
name: Parodi, Oliver
name: Potthast, Thomas
name: Singer-Brodowski, Mandy
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: culture of sustainability
subject: higher education
subject: real-world-experiments
subject: sustainability transformation
subject: 300 Sozialwissenschaften::300 Sozialwissenschaften, Soziologie::300 Sozialwissenschaften

description: Die Hochschulrektorenkonferenz hat sich 2018 für eine ,,Kultur der Nachhaltigkeit“ ausgesprochen. Um dieses neue Leitbild für die Hochschulentwicklung auszugestalten, hat sich das Verbundvorhaben Hochschulen in Gesellschaft ‐ Realexperimente transformativer Lern- und Forschungsprozesse für eine Kultur der Nachhaltigkeit an Hochschulen gegründet. Es will alle relevanten Stakeholder von Hochschulen ansprechen und einen wichtigen Impuls für die Nachhaltigkeitstransformation an Hochschulen setzen.
Exploiting the full potential of photometric quasar surveys: Optimal power spectra through blind mitigation of systematics
Creators: name: Leistedt, Boris
name: Peiris, Hiranya V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present optimal measurements of the angular power spectrum of the XDQSOz catalogue of photometric quasars from the Sloan Digital Sky Survey. These measurements rely on a quadratic maximum likelihood estimator that simultaneously measures the auto- and cross-power spectra of four redshift samples, and provides minimum-variance, unbiased estimates even at the largest angular scales. Since photometric quasars are known to be strongly affected by systematics such as spatially-varying depth and stellar contamination, we introduce a new framework of extended mode projection to robustly mitigate the impact of systematics on the power spectrum measurements. This technique involves constructing template maps of potential systematics, decorrelating them on the sky, and projecting out modes which are significantly correlated with the data. Our method is able to simultaneously process several thousands of nonlinearly-correlated systematics, and mode projection is performed in a blind fashion. Using our final power spectrum measurements, we find a good agreement with theoretical predictions, and no evidence for further contamination by systematics. Extended mode projection not only obviates the need for aggressive sky and quality cuts, but also provides control over the level of systematics in the measurements, enabling the search for small signals of new physics while avoiding confirmation bias.
description: 13 pages, 8 figures. v2: version accepted by MNRAS. v3: systematics templates publicly available on www.earlyuniverse.org/code, no change to paper
Function spaces, time derivatives and compactness for evolving families of Banach spaces with applications to PDEs
Creators: name: Alphonse, Amal
name: Caetano, Diogo
name: Djurdjevac, Ana
name: Elliott, Charles M.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: function spaces
subject: time derivatives
subject: Banach spaces
subject: 500 Naturwissenschaften und Mathematik::510 Mathematik::510 Mathematik

description: We develop a functional framework suitable for the treatment of partial differential equations and variational problems on evolving families of Banach spaces. We propose a definition for the weak time derivative that does not rely on the availability of a Hilbertian structure and explore conditions under which spaces of weakly differentiable functions (with values in an evolving Banach space) relate to classical Sobolev–Bochner spaces. An Aubin–Lions compactness result is proved. We analyse concrete examples of function spaces over time-evolving spatial domains and hypersurfaces for which we explicitly provide the definition of the time derivative and verify isomorphism properties with the aforementioned Sobolev–Bochner spaces. We conclude with the proof of well posedness for a class of nonlinear monotone problems on an abstract evolving space (generalising the evolutionary p-Laplace equation on a moving domain or surface) and identify some additional problems that can be formulated with the setting developed in this work.
Effect of electromagnetic boundary conditions on the onset of small-scale dynamos driven by convection
Creators: name: Fontana, Mauro
name: Mininni, Pablo D.
name: Dmitruk, Pablo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: We present a high-order numerical study of the dependence of the dynamo onset on different electromagnetic boundary conditions, in convecting Boussinesq flows forced by a temperature gradient. Perfectly conducting boundaries, vacuum, and mixed electromagnetic boundary conditions are considered, using a method that treats fields and boundary conditions with close to spectral accuracy. Having one or two conducting boundaries greatly facilitates dynamo action. For the mixed case it is shown that the critical magnetic Reynolds number becomes independent of the Rayleigh number, Ra, for sufficiently large Ra.
Extracting electric dipole breakup cross section of one-neutron halo nuclei from breakup observables
Creators: name: Yoshida, Kazuki
name: Fukui, Tokuro
name: Minomo, Kosho
name: Ogata, Kazuyuki
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: How to extract an electric dipole (E1) breakup cross section σ(E1) from one- neutron removal cross sections measured by using 12C and 208Pb targets, σ_(-1n)^C and σ_(-1n)^Pb, respectively, is discussed. It is shown that within about 5% error, σ(E1) can be obtained by subtracting Γσ_(-1n)^C from σ_(- 1n)^Pb, as assumed in preceding studies. However, for the reaction of weakly-bound projectiles, the scaling factor Γis found to be two times as large as that usually adopted. As a result, we obtain 13-20% smaller σ(E1) of 31Ne at 250 MeV/nucleon than extracted in a previous analysis of experimental data. By compiling the values of Γobtained for several projectiles, Γ=(2.30 +/- 0.41)\exp(- S_n)+(2.43 +/- 0.21) is obtained, where S_n is the neutron separation energy. The target mass number dependence of the nuclear parts of the one-neutron removal cross section and the elastic breakup cross section is also investigated.
description: 12 pages, 4 figures, 7 tables, published on PTEP
Overview of an MBA in Educational Leadership (International) Dissertation on "Examining international leadership practices to promote a positive research culture in Higher Education Institutes"
Creators: name: Lacey, Seán
Publisher: name: Zenodo
Year: 2022
Subjects: Research Integrity
Open Research
Leadership Practices
Research Culture
Higher Education Institutes

description: Abstract In Higher Education Institutes (HEIs) there is a growing emphasis on promoting good research practices in all aspects of research, from fundamental research to applied research to commercialisation. This study examines international leadership practices to promote a positive research culture in HEIs in terms of types of leadership models senior research leaders find are most effective, along with the practices they have found to be most impactful in leading change. The research design was constructed using semi-structured interviews with five senior research leaders. Countries that were members of the European Network of Research Integrity Offices (ENRIO), with HEIs that were members of the European Association of Research Management and Administration (EARMA) were used as part of the sample selection process. With the topic being under-researched, the examination was kept as a small-scale exploratory study using opportunistic and purposive sampling to recruit participants. Data analysis was carried out using NVivo. Findings from the research study showed that the overarching leadership style to promote a positive research culture within HEIs was collective, with adaptive and competent boundary spanning characteristics, along with cognisance of the need for continuous professional development. There was agreement among all participants that change in the research culture is occurring, and leaders need to adapt to these changes. Findings also outlined that in order for HEIs to be proactive as opposed to reactive to change, evidenced-based research in collaboration with the future users is essential, requiring support from management in resourcing the appropriate infrastructure and training. Furthermore, findings suggested that HEI values and principles need first to be agreed and then subsequently complemented by the necessary policies and training at the various levels within the HEI. Research integrity and open research were seen as integral components to promoting a positive research culture in HEIs.
Supplementary document for Deep background-mismodeling-learned reconstruction for high-accuracy fluorescence diffuse optical tomography - 6438301.pdf
Creators: name: Deng, Yong
name: Jiang, Yuxuan
name: Liu, Kaixuan
name: Li, Wensong
name: Luo, Qingming
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: supplementary materials
Application of Transfer Learning to Neutrino Interaction Classification
Creators: name: Chappell, Andrew
name: Whitehead, Leigh H.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Training deep neural networks using simulations typically requires very large numbers of simulated events. This can be a large computational burden and a limitation in the performance of the deep learning algorithm when insufficient numbers of events can be produced. We investigate the use of transfer learning, where a set of simulated images are used to fine tune a model trained on generic image recognition tasks, to the specific use case of neutrino interaction classification in a liquid argon time projection chamber. A ResNet18, pre-trained on photographic images, was fine-tuned using simulated neutrino images and when trained with one hundred thousand training events reached an F1 score of $0.896 \pm 0.002$ compared to $0.836 \pm 0.004$ from a randomly-initialised network trained with the same training sample. The transfer-learned networks also demonstrate lower bias as a function of energy and more balanced performance across different interaction types.
description: 10 pages, 7 figures. Update to align with final published version, including commentary on network biases
Detection of Inelastic Dark Matter via Electron Recoils in SENSEI
Creators: name: Gu, Yuchao
name: Wu, Lei
name: Zhu, Bin
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The low-threshold experiment SENSEI, which uses the ultralow-noise silicon Skipper-CCD to explore light dark matter from the halo, has achieved the most rigorous limitations on light DM-electron scattering cross section. In this work, we investigate the inelastic DM-electron scattering process with the SENSEI data and derive the constraints on the inelastic dark matter model with a $U(1)$ gauge boson as the mediator. Comparing with elastic scattering process, we find that the down-scattering process with the mass splitting $δ\equiv m_{χ_2}-m_{χ_1}<0$ is more strongly constrained while the up-scattering process $δ>0$ gets the weaker limits. For the down-scattering process with mass splitting $δ\sim -5$ eV, the DM mass $m_χ$ can be excluded down to as low as 0.1 MeV.
description: 4 figures, 1 table, some discussions and references added; match the published version in PRD
Therapies with CCL25 require controlled release via microparticles to avoid strong inflammatory reactions
Creators: name: Spinnen, Jacob
name: Fröhlich, K.
name: Sinner, N.
name: Stolk, M.
name: Ringe, J.
name: Shopperly, L.
name: Sittinger, Michael
name: Dehne, Tilo
name: Seifert, Martina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: C–C motif chemokine ligand 25 (CCL25)
subject: Poly (lactic-co-glycolic acid) (PLGA)
subject: immune cell regulation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Chemokine therapy with C-C motif chemokine ligand 25 (CCL25) is currently under investigation as a promising approach to treat articular cartilage degeneration. We developed a delayed release mechanism based on Poly (lactic-co-glycolic acid) (PLGA) microparticle encapsulation for intraarticular injections to ensure prolonged release of therapeutic dosages. However, CCL25 plays an important role in immune cell regulation and inflammatory processes like T-cell homing and chronic tissue inflammation. Therefore, the potential of CCL25 to activate immune cells must be assessed more thoroughly before further translation into clinical practice. The aim of this study was to evaluate the reaction of different immune cell subsets upon stimulation with different dosages of CCL25 in comparison to CCL25 released from PLGA particles. Results: Immune cell subsets were treated for up to 5 days with CCL25 and subsequently analyzed regarding their cytokine secretion, surface marker expression, polarization, and migratory behavior. The CCL25 receptor C-C chemokine receptor type 9 (CCR9) was expressed to a different extent on all immune cell subsets. Direct stimulation of peripheral blood mononuclear cells (PBMCs) with high dosages of CCL25 resulted in strong increases in the secretion of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta), tumor-necrosis-factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), upregulation of human leukocyte antigen-DR (HLA-DR) on monocytes and CD4(+) T-cells, as well as immune cell migration along a CCL25 gradient. Immune cell stimulation with the supernatants from CCL25 loaded PLGA microparticles caused moderate increases in MCP-1, IL-8, and IL-1 beta levels, but no changes in surface marker expression or migration. Both CCL25-loaded and unloaded PLGA microparticles induced an increase in IL-8 and MCP-1 release in PBMCs and macrophages, and a slight shift of the surface marker profile towards the direction of M2-macrophage polarization. Conclusions: While supernatants of CCL25 loaded PLGA microparticles did not provoke strong inflammatory reactions, direct stimulation with CCL25 shows the critical potential to induce global inflammatory activation of human leukocytes at certain concentrations. These findings underline the importance of a safe and reliable release system in a therapeutic setup. Failure of the delivery system could result in strong local and systemic inflammatory reactions that could potentially negate the benefits of chemokine therapy.
Evidence for a less high acceptor substrate specificity of gastric histamine methyltransferase: methylation of imidazole compounds
Creators: name: Barth, H.
name: Crombach, M.
name: Schunack, W.
name: Lorenz, Wilfried
Publisher: name: Universität Regensburg
Year: 1980
Subjects: subject: 610 Medizin
subject: Alkylation
subject: Animals
subject: Enzyme Inhibitors/pharmacology
subject: Histamine H1 Antagonists/pharmacology
subject: Histamine H2 Antagonists/pharmacology
subject: Histamine N-Methyltransferase/metabolism
subject: Imidazoles/metabolism
subject: Methylation
subject: Methyltransferases/metabolism
subject: Stomach/enzymology
subject: Substrate Specificity
subject: Swine

description: The transmethylation catalysed by HMT (EC 2.1.1.8)* has been considered as absolutely specific for histamine as acceptor substrate. In this investigation Nα-MH, Nα,NαDMH, spinaceamine and synthetically prepared 4-[(2-amino-ethylmercapto)-methyl]-imidazole could be identified as further methyl-group accepting substrates (optimum substrate concentration ~ 1 mM), but the yield of extractable 14C-labelled methylation products was never greater than 21 per cent of that of histamine. The 3 per cent methylation of Nα,Nα-DMH was considerably smaller than that of 33 per cent reported in the literature. This discrepancy was resolved and found to be ascribable to an inappropriate product extraction procedure used in the former experiments. When Nα-MH and Nα,Nα-DMH were the substrates, the corresponding products were isolated by t.1.c. in four different solvent systems and identified to be Nτ,Nα-DMH and Nτ,Nα,Nα-TMH. Thus HMT catalysed in all cases a uniform methyl of the Nα-nitrogen atom of the imidazole nucleus. The investigation of a series of various substituted imidazole compounds revealed that a methylation of the ring system had to be considered, if it was not substituted in the Nτ-, 2- or Nπ-position and if it carried a 4-substituent with a strong basic aminogroup, whereas substitution in the ring 5-position seemed to be of minor importance. Furthermore H1-receptor antagonists, H2-receptor antagonists, the non-imidazole H2-receptor agonist dimaprit, as well as the enzyme inhibitors aminoguanidine, tranylcypromine, pargyline and nicolinamide, were not methylated under the catalysis of HMT. The evidence for a less high substrate specificity of HMT may influence the relevance of histamine determinations using this enzyme: caution seems necessary.
Monetary policy, external instruments, and heteroskedasticity
Creators: name: Schlaak, Thore
name: Rieth, Malte
name: Podstawski, Maximilian
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Monetary policy
subject: structural vector autoregressions
subject: identification with external instrument
subject: heteroskedasticity
subject: Markov switching
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: We develop a structural vector autoregressive framework that combines external instruments and heteroskedasticity for identification of monetary policy shocks. We show that exploiting both types of information sharpens structural inference, allows testing the relevance and exogeneity condition for instruments separately using likelihood ratio tests, and facilitates the economic interpretation of the structural shock of interest. We test alternative instruments and find that narrative and model‐based measures are valid, while high‐frequency data instruments show signs of invalidity. Finally, we document that monetary shocks identified with both a valid instrument and heteroskedasticity have larger effects on production and prices than monetary shocks identified via an instrument only.
On the convergence of Maronna's $M$-estimators of scatter
Creators: name: Chitour, Yacine
name: Couillet, Romain
name: Pascal, Frederic
Publisher: name: arXiv
Year: 2014
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: In this paper, {we propose an alternative proof for the uniqueness} of Maronna's $M$-estimator of scatter (Maronna, 1976) for $N$ vector observations $\mathbf y_1,...,\mathbf y_N\in\mathbb R^m$ under a mild constraint of linear independence of any subset of $m$ of these vectors. This entails in particular almost sure uniqueness for random vectors $\mathbf y_i$ with a density as long as $N>m$. {This approach allows to establish further relations that demonstrate that a properly normalized Tyler's $M$-estimator of scatter (Tyler, 1987) can be considered as a limit of Maronna's $M$-estimator. More precisely, the contribution is to show that each $M$-estimator converges towards a particular Tyler's $M$-estimator.} These results find important implications in recent works on the large dimensional (random matrix) regime of robust $M$-estimation.
An improved method for the determination of histamine release in man: its application in studies with propanidid and thiopentone
Creators: name: Lorenz, Wilfried
name: Doenicke, A.
name: Meyer, R.
name: Reimann, H. J.
name: Kusche, J.
name: Barth, H.
name: Geesing, H.
name: Hutzel, M.
name: Weissenbacher, B.
Publisher: name: Universität Regensburg
Year: 1972
Subjects: subject: 610 Medizin
subject: Adult
subject: Atropine/pharmacology
subject: Basophils/drug effects
subject: Blood Pressure/drug effects
subject: Electroencephalography
subject: Female
subject: Gastric Juice/secretion
subject: Histamine/blood
subject: Histamine H1 Antagonists
subject: Histamine Release/drug effects
subject: Humans
subject: Intubation, Gastrointestinal
subject: Ketones/pharmacology
subject: Leukocyte Count
subject: Male
subject: Methods
subject: Propanidid/pharmacology
subject: Thiopental/pharmacology

description: Histamine release by propanidid and thiopentone was demonstrated with the use of a highly sensitive and specific method for determining histamine in human plasma. 5 min after i.v. administration of propanidid and 3 min after thiopentone, the plasma histamine level was increased by 350 and 420% respectively. In whole blood, histamine release could be demonstrated only when the basophil content remained constant. This was the case in about 50% of test persons after injection of propanidid, but not after administration of thiopentone where the basophil content decreased in all probands by about 35%. The increase of the histamine concentration in plasma was 3 ng/ml and in whole blood, 24 ng/ml. Half-maximum gastric acid secretion was elicited by injection of propanidid and thiopentone. It was increased by very rapid application of propanidid and diminished by premedication with atropine by about 30%. The changes in plasma histamine and gastric secretion were parallel over 30 min, whereas tachycardia and peripheral arterial hypotension lasted for only 3–4 min. During i.v. infusion of histamine a correlation could be shown between the doses infused, (15–90 ng/kg)/min, and the elevation of the plasma histamine concentration. 3 ng/ml plasma were measured at a dose of (45 ng/kg)/min, which induced a half-maximum gastric secretion, but was without effect on blood pressure and heart rate. It is concluded that only the increase of plasma histamine concentration, not that of whole blood, represented the release of free, pharmacologically active histamine. In normal test persons, hisramine release by propanidid and thiopentone is without significant clinical consequences, but it is important in anaphylactoid incidents occurring during anesthesia with these substances.
title: Zur Erinnerung an Herrn Pfarrer Gottfried Ludwig-Neuhaus, Spitalprediger in Bern
title: geb. den 14. Februar 1832, gest. den 22. Mai 1889
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Buchdruckerei K. J. Wyss
Year: 1889
Subjects: subject: 230 Christentum, christliche Theologie
subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Ludwig-Neuhaus, Gottfried
subject: Bern

description: Enthält: Ansprachen in der Spitalkappelle am Begräbnisstage, 24. Mai 1889: Rede von Herrn Pfarrer Rohr; Rede von Herrn Pfarrer Hugendubel; Gedichte: Von Herrn Pfarrer Hugendubel; Aus dem Burgerspital von Fräulein A. Hermann
Covariant second-order perturbations in generalized two-field inflation
Creators: name: Tzavara, Eleftheria
name: Mizuno, Shuntaro
name: van Tent, Bartjan
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine the covariant properties of generalized models of two-field inflation, with non-canonical kinetic terms and a possibly non-trivial field metric. We demonstrate that kinetic-term derivatives and covariant field derivatives do commute in a proper covariant framework, which was not realized before in the literature. We also define a set of generalized slow-roll parameters, using a unified notation. Within this framework, we study the most general class of models that allows for well-defined adiabatic and entropic sound speeds, which we identify as the models with parallel momentum and field velocity vectors. For these models we write the exact cubic action in terms of the adiabatic and isocurvature perturbations. We thus provide the tool to calculate the exact non-Gaussianity beyond slow-roll and at any scale for these generalized models. We illustrate our general results by considering their long-wavelength limit, as well as with the example of two-field DBI inflation.
description: 39 pages, no figures, minor changes and clarifications
Muon anomalous magnetic moment and positron excess at AMS-02 in a gauged horizontal symmetric model
Creators: name: Tomar, Gaurav
name: Mohanty, Subhendra
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We studied an extension of the standard model with a fourth generation of fermions to explain the discrepancy in the muon $(g-2)$ and explain the positron excess seen in the AMS-02 experiment. We introduce a gauged $SU(2)_{HV}$ horizontal symmetry between the muon and the 4th generation lepton families. The 4th generation right-handed neutrino is identified as the dark matter with mass $\sim 700$ GeV. The dark matter annihilates only to $(μ^+ μ^-)$ and $(ν^c_μ~ν_μ)$ states via $SU(2)_{HV}$ gauge boson. The $SU(2)_{HV}$ gauge boson with mass $\sim 1.4$ TeV gives an adequate contribution to the $(g-2)$ of muon and fulfill the experimental constraint from BNL measurement. The higgs production constraints from 4th generation fermions is evaded by extending the higgs sector.
description: Journal version, to appear in JHEP
Machine-guided Exploration and Calibration of Astrophysical Simulations
Creators: name: Oh, Boon Kiat
name: An, Hongjun
name: Shin, Eun-jin
name: Kim, Ji-hoon
name: Hong, Sungwook E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We apply a novel method with machine learning to calibrate sub-grid models within numerical simulation codes to achieve convergence with observations and between different codes. It utilizes active learning and neural density estimators. The hyper parameters of the machine are calibrated with a well-defined projectile motion problem. Then, using a set of 22 cosmological zoom simulations, we tune the parameters of a popular star formation and feedback model within Enzo to match simulations. The parameters that are adjusted include the star formation efficiency, coupling of thermal energy from stellar feedback, and volume into which the energy is deposited. This number translates to a factor of more than three improvements over manual calibration. Despite using fewer simulations, we obtain a better agreement to the observed baryon makeup of a Milky-Way (MW) sized halo. Switching to a different strategy, we improve the consistency of the recommended parameters from the machine. Given the success of the calibration, we then apply the technique to reconcile metal transport between grid-based and particle-based simulation codes using an isolated galaxy. It is an improvement over manual exploration while hinting at a less known relation between the diffusion coefficient and the metal mass in the halo region. The exploration and calibration of the parameters of the sub-grid models with a machine learning approach is concluded to be versatile and directly applicable to different problems.
Histamine release in man by propanidid and thiopentone: pharmacological effects and clinical consequences
Creators: name: Lorenz, Wilfried
name: Doenicke, A.
name: Meyer, R.
name: Reimann, H. J.
name: Kusche, J.
name: Barth, H.
name: Geesing, H.
name: Hutzel, M.
name: Weissenbacher, B.
Publisher: name: Universität Regensburg
Year: 1972
Subjects: subject: 610 Medizin
subject: Adult
subject: Anaphylaxis
subject: Arteries
subject: Basophils
subject: Blood Pressure
subject: Drug Hypersensitivity
subject: Electrocardiography
subject: Female
subject: Gastric Juice/secretion
subject: Glucocorticoids/administration & dosage
subject: Heart Rate
subject: Histamine/blood
subject: Histamine H1 Antagonists/administration & dosage
subject: Histamine Release/drug effects
subject: Humans
subject: Leukocyte Count
subject: Male
subject: Middle Aged
subject: Plasma Substitutes/therapeutic use
subject: Preanesthetic Medication
subject: Propanidid/pharmacology
subject: Pulse
subject: Skin Tests
subject: Solvents
subject: Thiopental/pharmacology

description: Using a new, highly sensitive and specific method for the determination of histamine in human plasma, it was shown that release of histamine followed injection of propanidid and thiopentone. Observations of gastric secretion, arterial pressure and pulse rate supported these findings. In normal persons the release of histamine had no special clinical significance. On the other hand, when anaphylactoid reactions occurred following propanidid injection histamine release was so massive as to explain the severe clinical signs and symptoms observed. In this study no reactions occurred following thiopentone injection. Although it seems likely that massive histamine release can occur during anaphylactoid reactions with this anaesthetic, we have no observations to confirm this. In one case it was shown that premedication with glucocorticoids and anti-histaminics and therapy with plasma substitutes could prevent the development of a severe reaction.
Procesi's Conjecture on the Formanek-Weingarten Function is False
Creators: name: Dołęga, Maciej
name: Novak, Jonathan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Combinatorics (math.CO)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper, we disprove a recent monotonicity conjecture of C. Procesi on the generating function for monotone walks on the symmetric group, an object which is equivalent to the Weingarten function of the unitary group.
description: 4 pages
Unitarity, Crossing Symmetry and Duality of the S-matrix in large N Chern-Simons theories with fundamental matter
Creators: name: Jain, Sachin
name: Mandlik, Mangesh
name: Minwalla, Shiraz
name: Takimi, Tomohisa
name: Wadia, Spenta R.
name: Yokoyama, Shuichi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present explicit computations and conjectures for $2 \to 2$ scattering matrices in large $N$ {\it $U(N)$} Chern-Simons theories coupled to fundamental bosonic or fermionic matter to all orders in the 't Hooft coupling expansion. The bosonic and fermionic S-matrices map to each other under the recently conjectured Bose-Fermi duality after a level-rank transposition. The S-matrices presented in this paper may be regarded as relativistic generalization of Aharonov-Bohm scattering. They have unusual structural features: they include a non analytic piece localized on forward scattering, and obey modified crossing symmetry rules. We conjecture that these unusual features are properties of S-matrices in all Chern-Simons matter theories. The S-matrix in one of the exchange channels in our paper has an anyonic character; the parameter map of the conjectured Bose-Fermi duality may be derived by equating the anyonic phase in the bosonic and fermionic theories.
description: 66 pages+ 45 pages appendices, 20 figures, Few typos corrected and few references added
Flat Thomas-Fermi artificial atoms
Creators: name: Ovchinnikov, Yu. N.
name: Halder, Avik
name: Kresin, Vitaly V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We consider two-dimensional (2D) "artificial atoms" confined by an axially symmetric potential $V(ρ)$. Such configurations arise in circular quantum dots and other systems effectively restricted to a 2D layer. Using the semiclassical method, we present the first fully self-consistent and analytic solution yielding equations describing the density distribution, energy, and other quantities for any form of $V(ρ)$ and an arbitrary number of confined particles. An essential and nontrivial aspect of the problem is that the 2D density of states must be properly combined with 3D electrostatics. The solution turns out to have a universal form, with scaling parameters $ρ^2/R^2$ and $R/a_B^*$ ($R$ is the dot radius and $a_B^*$ is the effective Bohr radius).
Self-calibration of photometric redshift scatter from DECaLS DR8 power spectrum and validation with simulated catalogues
Creators: name: Peng, Hui
name: Xu, Haojie
name: Zhang, Le
name: Chen, Zhao
name: Yu, Yu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The uncertainty in the photometric redshift estimation is one of the major systematics in weak lensing cosmology. The self-calibration method is able to reduce this systematics without assuming strong priors. We improve the recently proposed self-calibration algorithm to enhance the stability and robustness with the noisy measurement. The improved algorithm is tested on the power spectra measured from the simulated catalogues constructed according to DECaLS DR8 photometric catalogue. For the fiducial analysis with 5 equal-width redshift bins over $0
description: 15 pages, 13 figures, accepted for publication in MNRAS