cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of ritonavir analogs antiretroviral natural compounds against SARS-CoV-2 envelope protein
Creators: name: Negi, Shivani
name: Kamboj, Nitin Kumar
name: K., Gireesh Babu
name: Yadava, Umesh
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Since the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported from Wuhan, China, there has been a surge in scientific research to find a permanent cure for the disease. The main challenge in effective drug discovery is the continuously mutating nature of the SARS-CoV-2 virus. Thus, we have used the I-TASSER modeling to predict the structure of the SARS-CoV-2 viral envelope protein followed by combinatorial computational assessment to predict its putative potential small molecule inhibitors. As early treatment with ritonavir in combination was associated with faster time to clinical improvement and/or virological clearance, we aimed to retrieve analogs of ritonavir to find ideal inhibitors for SARS-CoV-2 viral envelope protein. The collected ligands were screened against the predicted binding pocket of viral envelope protein using extra precision (XP) docking protocol and the first four best-docked compounds were studied for complex stability using 300 ns all-atom molecular dynamics simulations embedding within the cellular membrane. Among the selected compounds, ZINC64859171 and ZINC1221429 showed considerable stability and interactions by comparison to the reference compound, i.e., Ritonavir (ZINC3944422). Moreover, the post-simulation analysis suggested the considerable binding affinity and induced conformation changes in the respective docked complexes against Ritonavir. Altogether, the obtained results demonstrated the putative potential of screened ritonavir analogs, i.e., ZINC64859171, against the envelope protein of SARS-CoV-2 and can be considered for further drug development in the treatment of the COVID-19 pandemic.
On-line Policy Improvement using Monte-Carlo Search
Creators: name: Tesauro, Gerald
name: Galperin, Gregory R.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: We present a Monte-Carlo simulation algorithm for real-time policy improvement of an adaptive controller. In the Monte-Carlo simulation, the long-term expected reward of each possible action is statistically measured, using the initial policy to make decisions in each step of the simulation. The action maximizing the measured expected reward is then taken, resulting in an improved policy. Our algorithm is easily parallelizable and has been implemented on the IBM SP1 and SP2 parallel-RISC supercomputers.
 We have obtained promising initial results in applying this algorithm to the domain of backgammon. Results are reported for a wide variety of initial policies, ranging from a random policy to TD-Gammon, an extremely strong multi-layer neural network. In each case, the Monte-Carlo algorithm gives a substantial reduction, by as much as a factor of 5 or more, in the error rate of the base players. The algorithm is also potentially useful in many other adaptive control applications in which it is possible to simulate the environment.
description: Accompanied by oral presentation by Gregory Galperin at NeurIPS 1996 (then known as NIPS*96)
WISE2150-7520AB: A very low mass, wide co-moving brown dwarf system discovered through the citizen science project Backyard Worlds: Planet 9
Creators: name: Faherty, Jacqueline K.
name: Goodman, Sam
name: Caselden, Dan
name: Colin, Guillaume
name: Kuchner, Marc J.
name: Meisner, Aaron M.
name: Gagne', Jonathan
name: Schneider, Adam C.
name: Gonzales, Eileen C.
name: Gagliuffi, Daniella C. Bardalez
name: Logsdon, Sarah E.
name: Allers, Katelyn
name: Burgasser, Adam J.
name: Collaboration, The Backyard Worlds Planet 9
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the discovery of WISE2150-7520AB (W2150AB): a widely separated (~ 341 AU) very low mass L1 + T8 co-moving system. The system consists of the previously known L1 primary 2MASS J21501592-7520367 and a newly discovered T8 secondary found at position 21:50:18.99 -75:20:54.6 (MJD=57947) using Wide-field Infrared Survey Explorer (WISE) data via the Backyard Worlds: Planet 9 citizen science project. We present Spitzer ch1 and ch2 photometry (ch1-ch2= 1.41 +/-0.04 mag) of the secondary and FIRE prism spectra of both components. The sources show no peculiar spectral or photometric signatures indicating that each component is likely field age. Using all observed data and the Gaia DR2 parallax of 41.3593 +/- 0.2799 mas for W2150A we deduce fundamental parameters of log(Lbol/Lsun)=-3.69 +/- 0.01, Teff=2118 +/- 62 K, and an estimated mass=72 +/- 12 MJup for the L1 and log(Lbol/Lsun)=-5.64 +/- 0.02, Teff=719 +/- 61 K, and an estimated mass=34 +/- 22 MJup for the T8. At a physical separation of ~341 AU this system has Ebin = 10^41 erg making it the lowest binding energy system of any pair with Mtot < 0.1 Msun not associated with a young cluster. It is equivalent in estimated mass ratio, Ebin, and physical separation to the ~ 2 Myr M7.25 + M8.25 binary brown dwarf 2MASS J11011926-7732383AB (2M1101AB) found in the Chameleon star forming region. W2150AB is the widest companion system yet observed in the field where the primary is an L dwarf or later.
description: ApJ accepted October 2019. 18 pages, 8 Figures, two tables. All tabular data is available on a viewable/commentable google sheet here: https://docs.google.com/spreadsheets/d/1bG6BZl7wAus9JRjb_zNVP0PwpBUqpH_IG_daPxWi024/edit?usp=sharing
Quark Loop Effects in Semileptonic Form Factors for Heavy-Light Mesons
Creators: name: Bernard, C.
name: DeTar, C.
name: Gottlieb, Steven
name: Gregory, E.
name: Heller, Urs
name: McNeile, C.
name: Osborn, J.
name: Sugar, R.
name: Toussaint, D.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present preliminary results of a determination of the semileptonic form factor for the decay of pseudoscalar heavy-light mesons to pseudoscalar light-light mesons in full QCD. In this preliminary study we focus on the effects of dynamical quark loops. Accordingly, we compare results of simulations with matched quenched and Asqtad dynamical gauge configurations. The latter include three flavors of light quarks. Our simulation uses clover Wilson valence quarks, treated in the Fermilab formalism. Preliminary results, as yet uncorrected by continuum matching factors, suggest a measurable enhancement in the form factor due to dynamical quark loops over the accessible range of $q^2$.
description: Lattice2003(heavy)
Reactive transport of trace elements and isotopes in the Eutaw coastal plain aquifer, Alabama
Creators: name: Lee, Ming-Kuo
name: Griffin, James
name: Saunders, James
name: Wang, Yang
name: Jean, Jiin-Shuh
Publisher: name: American Geophysical Union
Year: 2007
Subjects: groundwater
bacteria
ion exchange
trace elements
coastal plain
isotopes

description: We integrate groundwater geochemistry, mineralogy, and numerical modeling techniques to study the reactive transport of heavy metals and isotopes in the Eutaw coastal plain aquifer, Alabama. Geochemical data show that the elevated concentrations of Fe, Mn, and Sr can be correlated with high pH and alkalinity. These geochemical correlations suggest that that elevated metal concentrations may be derived from bacterial iron and manganese reduction. Geochemical modeling of bacterial Fe(III) and Mn(IV) reduction shows that the biotransformation of iron and manganese minerals could control mobility and concentrations of Fe and Mn in coastal plain aquifers. Petrographic, SEM, and EDAX studies of sediments show the formation of biogenic siderite, rhodochrosite, and pyrite in sediments associated with Fe- and Mn-rich groundwater. Rhodochrosite and siderite occur together as spheroids ( approximate to 1.0 mm) in which rhodochrosite forms the center and siderite forms an outer rind, which is consistent with the redox sequence of mineral precipitation predicted by the geochemical modeling. The low delta C-13 ratios of siderite and rhodochrosite ( - 14.4 to - 15.4 parts per thousand, PDB) and groundwater DIC (- 20.6 to - 14.1 parts per thousand, PDB) imply carbon of biogenic origin. Higher DIC-delta C-13 levels are found to be correlated with elevated Fe and Mn concentrations and high pH values of groundwater. This unexpected result implies novel carbon isotopic fractionation processes associated with bacterial Fe( III) reduction. We used Cl-36/Cl ratios of groundwater and isotope transport modeling to calculate the residence time of regional groundwater in the Eutaw aquifer. The calculation considering the natural decay only would yield Cl-36 levels that are significantly higher than field data, suggesting that a significant mixing with Cl-rich, older groundwater at depth is an important reason for substantial Cl-36 depletion along flow path.
Participatory agri-environmental governance and integrating multi-actor knowledge: a case study from Ireland
Creators: name: McCarthy, Jack
name: Bonnin, Christine
name: Meredith, David
name: McCarthy, Jack
name: Bonnin, Christine
name: Meredith, David
Publisher: name: Unknown
Year: 2019
Subjects: subject: Agricultural and Food Policy
subject: Environmental Economics and Policy
subject: agri-environmental governance
subject: multi-actor cooperation
subject: Ireland
subject: European Innovation Partnerships Initiative

description: agri-environmental governance multi-actor cooperation
Thermodynamics of strong coupling 2-color QCD with chiral and diquark condensates
Creators: name: Nishida, Yusuke
name: Fukushima, Kenji
name: Hatsuda, Tetsuo
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: 2-color QCD (quantum chromodynamics with N_c=2) at finite temperature T and chemical potential μis revisited in the strong coupling limit on the lattice with staggered fermions. The phase structure in the space of T, μ, and the quark mass m is elucidated with the use of the mean field approximation and the 1/d expansion (d being the number of spatial dimensions). We put special emphasis on the interplay among the chiral condensate , the diquark condensate , and the quark density in the T-μ-m space. Simple analytic formulae are also derived without assuming μnor m being small. Qualitative comparisons are made between our results and those of recent Monte-Carlo simulations in 2-color QCD.
description: Contribution to the Hidenaga Yamagishi Commemorative volume of Physics Reports, edited by E. Witten and I. Zahed; typos are corrected, references are updated
Spontaneously generated X-shaped light bullets
Creators: name: Di Trapani, P.
name: Valiulis, G.
name: Piskarskas, A.
name: Jedrkiewicz, O.
name: Trull, J.
name: Conti, C.
name: Trillo, S.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We observe the formation of an intense optical wavepacket fully localized in all dimensions, i.e. both longitudinally (in time) and in the transverse plane, with an extension of a few tens of fsec and microns, respectively. Our measurements show that the self-trapped wave is a X-shaped light bullet spontaneously generated from a standard laser wavepacket via the nonlinear material response (i.e., second-harmonic generation), which extend the soliton concept to a new realm, where the main hump coexists with conical tails which reflect the symmetry of linear dispersion relationship.
description: 5 pages, 4 figures, submitted for publication
Integrating PROV with DDI: Mechanisms of data discovery within the US Census Bureau
Creators: name: Block, Bill
name: Brown, Warren
name: Williams, Jeremy
name: Vilhuber, Lars
name: Lagoze, Carl
Publisher: name: Zenodo
Year: 2014

description: Within the United States Census Bureau, datasets are often derived by complex methods that are not always well documented. This derivation process, or provenance, can be hard to understand for a researcher attempting to use or explore a given dataset. Without understanding the provenance of a dataset, it can be impossible establish whether it is appropriate to use for a given investigation, because its history remains a black box with no way to see inside. The infrastructure upon which the semantic web is built provides a means to label the relationships of social science datasets with logical meaning according to standardized ontologies and controlled vocabularies. This paper outlines the work of the Comprehensive Data Documentation and Access Repository (CED2AR) to integrate provenance metadata encoded according to the W3C PROV ontology with a DDI-based repository with the aim of making US Census data more discoverable and accessible.
The geometry and environment of repeating FRBs
Creators: name: Du, Shuang
name: Wang, Weihua
name: Wu, Xuhao
name: Xu, Renxin
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a geometrical explanation for periodically and nonperiodically repeating fast radio bursts (FRBs) under neutron star (NS)-companion systems. We suggest a constant critical binary separation, $r_{\rm c}$, within which the interaction between the NS and companion can trigger FRB bursts. For an elliptic orbit with the minimum and maximum binary separations, $r_{\rm min}$ and $r_{\rm max}$, a periodically repeating FRB with an active period could be reproduced if $r_{\rm min}
description: 7 pages, 2 figures, accepted by MNRAS
The increasing impact of environmental policies on agriculture: Perspectives from Norway
Creators: name: Mittenzwei, Klaus
name: Øygarden, Lillian
name: Mittenzwei, Klaus
name: Øygarden, Lillian
Publisher: name: Unknown
Year: 2019
Subjects: subject: Agricultural and Food Policy
subject: Environmental Economics and Policy
subject: environmental policies
subject: agriculture
subject: Norway

description: The aim of this paper is twofold. Firstly, it gives an account of recent developments in Norwegian environmental policy that affect agriculture. Climate action and the protection of predators are two prominent examples of environmental policy with a potentially significant impact on agriculture. Secondly, we present results from a partial equilibrium model for the Norwegian agricultural sector in which we use various policy instruments to balance multiple agricultural and environmental objectives regarding agriculture.
An 40Ar/39Ar thermochronology of the Ofoten-Troms region: Implications for terrane amalgamation and extensional collapse of the northern Scandinavian Caledonides
Creators: name: Coker, Janet
name: Steltenpohl, Mark
name: Andresen, Arild
name: Kunk, Michael
Publisher: name: American Geophysical Union
Year: 1995

description: Fifteen Ar-40/Ar-39 cooling ages are reported for metamorphic hornblende and muscovite from far traveled terranes constituting the Ofoten nappe stack of northern Norway. Eight cooling ages on hornblende range from 425 to 394 Ma and seven muscovite ages, from the same or nearby outcrops as the hornblendes, range from 400 to 373 Ma. These data are compared with Ar-40/Ar-39 ages from over a large part of the northern Caledonides to evaluate regional mineral cooling patterns. Results indicate that (1) Scandian (Silurian-Devonian) metamorphism was predominant; (2) most of the nappes investigated contain some vestige of pre-Scandian tectonism and/or metamorphism; (3) hornblende and muscovite cooling ages are progressively younger to the west and south, which suggests a hinged-to-the-east mineral cooling pattern; and (4) a late, out-of-sequence thrust is the only disruption of this cooling pattern. Synmetamorphic amalgamation of the nappes resulted from Scandian A type subduction. The hinged-to-the-east mineral cooling pattern implies isostatic adjustment and exhumation of the footwall of a west clipping, crustal-scale extensional fault, located somewhere west of the present Norwegian coast, during late synorogenic gravitational collapse. The late out-of-sequence fault formed contemporaneously with uplift in the hinterland, implying a kinematic and temporal connection with east directed contractional faulting in the foreland.
Robust location estimators in regression models with covariates and responses missing at random
Creators: name: Bianco, Ana M.
name: Boente, Graciela
name: Wenceslao González-Manteiga
name: Pérez-González, Ana
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: This paper deals with robust marginal estimation under a general regression model when missing data occur in the response and also in some covariates. The target is a marginal location parameter given through an M-functional. To obtain robust Fisher-consistent estimators, properly defined marginal distribution function estimators are considered. These estimators avoid the bias due to missing values assuming a missing at random condition. Three methods are considered to estimate the marginal distribution which allows to obtain the M-location of interest: the well-known inverse probability weighting, a convolution-based method that makes use of the regression model and an augmented inverse probability weighting procedure that prevents against misspecification. Different aspects of their asymptotic behaviour are derived under regularity conditions. The robust studied estimators and their classical relatives are compared through numerical experiments under different missing data models, including clean and contaminated samples. The methodology is illustrated through a real data set.
A case for composting at school : food system literacy and sustainability education in action
Creators: name: Mann, Jessica R.
Publisher: name: The University of British Columbia
Year: 2023

description: This paper explores the phenomenon of composting at school through a pragmatic mixed-method research lens and makes the case for its potential as a transformative teaching tool. It delves into the history and science of composting to explore past and present practices and outlines its social and environmental impacts. Composting benefits include reducing greenhouse gas emissions, limiting landfill expansion, and the advantages to soil health and fertility. Composting connections to the curriculum and current educational movements are explored, including education for sustainability, place-based education, and new literacies. A case study of one specific experience of composting at school is examined in depth to draw conclusions surrounding the practice and develop a guide for future educators interested in implementing the practice into their pedagogy. In exploring and reflecting on all angles of the experience of composting at school, the conclusion has been made that composting is a transformative teaching tool that can provide students with knowledge, skills, and hope for a more sustainable future.
Nisista serrata Walker
Creators: name: Young, Catherine J.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Geometridae
Nisista
Nisista serrata

description: Nisista serrata Walker (Figs 415–420)
Oviposition
4♀ Code nos.: G90, G100, G285, G369.
Period of oviposition: 19 Aug.–14 Oct.
Batch size: 40.2 ± 7.2, (range): 5–85 (n = 16)
Realised fecundity: 4–343
 Note: McFarland (1988) reported a realized fecundity of 60 eggs from one female.
Incubation time (days): 9–18.
 Batch configuration and attachment: Attached; singly, small groups (Fig. 415).
 Colour: Pale yellow, shiny, opalescent becoming pinkish orange then greyish­brown on maturity (Fig. 415).
 Size (mm): (n=16) L=0.86 ± 0.01, W=0.63 ± 0.01, T=0.54 ± 0.01
Width/length: 0.73
No. of females: 3
 Aeropylar opening size (m) (n=7): L=2.38 ± 0.17, W=1.61 ± 0.09
Relative aeropylar opening size: 2.8
 Micropyles: Indistinct
No. of openings: 4
No. of cells in rosette: 9
No. of rows of cells in micropylar area: 4
 Shape: Moderately broad, bluntly ovoid; anterior pole slightly truncated, polar profile elliptical; dorso­ventrally flattened (Figs 415, 416 & 418).
 Characteristics: Egg marked all over by hexagonal cells (Fig. 418). Cell walls generally moderately broad, elevated, floors flat (Figs 418–420); micropylar cell walls narrow (Fig. 417). Aeropyles prominent, elevated, with moderately large domes, openings moderately large (Figs 416 & 420); present on all surfaces apart from middle of top of egg (Fig. 419). Chorion moderately rough, due to moderately sparse granulations (Fig. 419).
description: Published as part of Young, Catherine J., 2006, Descriptions of the eggs of some southern Australian Geometridae (Lepidoptera), pp. 1-294 in Zootaxa 1287 on pages 1-294
Taxonomy / Lexicon project at the US Bureau of Labor Statistics
Creators: name: Gillman, Daniel
Publisher: name: Zenodo
Year: 2014

description: The US Bureau of Labor Statistics is building a taxonomy and lexicon of terms and concepts of its technical language. The terms will also be linked to plain English words the public tends to use in place of them. The taxonomy will first be organized as a thesaurus, with possible expansion as resources permit and the need demands. The lexicon will be an alphabetical listing of the terms. The main drivers for the project are to support 1) the development of an agency wide series dissemination system, and 2) tagging documents, reports, and periodicals. An aim is to ensure consistent retrieval of documents and data. A team was assembled over the summer to address these issues. First, we gathered the terms and underlying concepts describing time series. These will be organized, and concurrently, the plain English words the public uses will be identified. Finally, terms, concepts, and plain English describing other data will be added. The initial phase of this project is due in January, but additional work and improvements will be necessary. Organizations that build thesauri find the system must be continually maintained, so this will be an on-going effort.
Using the X-ray Emission Lines of Seyfert 2 AGN to Measure Abundance Ratios
Creators: name: Jimenez-Garate, Mario A.
name: Khu, Toan
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We measure the metal abundance ratios in the X-ray photoionized gas located near the narrow line region of a sample of Seyfert 2 AGN. The high-resolution X-ray spectra observed with the Chandra high- and low-energy transmission grating spectrometers are compared with models of the resonant scattering and recombination emission from a plasma in thermal balance, and with multiple temperature zones. The abundance ratios in the sample are close to the Solar values, with slight over-abundances of N in NGC 1068, and of Ne in NGC 4151. Our X-ray spectral models use fewer degrees of freedom than previous works.
description: 2 pages, 1 figure, to appear in the proceedings of the conference "Multiwavelenth AGN Surveys", held in Cozumel, Mexico, December 2003
Powerful access to qualitative data: What's behind the UK QualiBank
Creators: name: Bell, Darren
Publisher: name: Zenodo
Year: 2014

description: In this paper we discuss how we have implemented a digital data browsing system for qualitative data based on highly structured data and metadata. Our system also enable paragraph-level citation. The crux of this exciting project has been the incorporation of object and sub-object level metadata using the QuDEx metadata schema in addition to DDI study-level metadata, and using the Text Encoding Initiative (TEI) for encoding textual data. The QuDex schema was initially released in 2006 following a project undertaken by the UK Data Archive and Metadata Technologies. QuDEx enables simple description of collections, data objects, parts of data objects, captures formal relationships between them, and analytical elements such as categories, codes and memos. The Text Encoding Initiative (TEI) has further provided a powerful tool for marking up bodies of text to enable rich web display. We will discuss how we have implemented the DDI, QuDEx and the TEI in the UK Quali Bank browsing system, and describe our use of technologies: an XML database (Base X) to store and deliver both metadata and textual data, and Solr and XQuery for powerful searching.
Quality of Life, Nontraditional Income, and Economic Growth New Development Opportunities for the Rural West
Creators: name: Nelson, Peter B.
name: Nelson, Peter B.
Publisher: name: Unknown
Year: 1999
Subjects: Community/Rural/Urban Development
Public Economics

description: Areas with high levels of natural amenities have enjoyed growing populations and income levels in the past decade. Much of this growth has come from the inmigration of people with income from self-employment or investments. These new migrants are usually well-educated and often work as executives or professionals or in such industries as finance, insurance, and real estate or business services. Communities may find that policies that enhance the quality of life (better schools, environmental protection, etc.) can attract more of these people who are in a financial position to act upon their residential preferences. This in turn can stimulate economic development.
The synthesis, carbonic anhydrase and acetylcholinesterase inhibition effects of sulfonyl chloride moiety containing oxazolidinones using an intramolecular aza-Michael addition
Creators: name: Yıldırım, Alper
name: Atmaca, Ufuk
name: Şahin, Ertan
name: Taslimi, Parham
name: Taskin-Tok, Tugba
name: Çelik, Murat
name: Gülçin, İlhami
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Oxazolidinones are used as various potent antibiotics, in organisms it acts as a protein synthesis inhibitor, focusing on an initial stage that encompasses the tRNA binding process. Novel intramolecular aza-Michael reactions devoid of metal catalysts have been introduced in an oxazolidone synthesis pathway, different from α,β-unsaturated ketones. Oxazolidinone derivatives were tested against acetylcholinesterase (AChE), carbonic anhydrase I and II (hCA I and hCA II) enzymes. All the synthesized compounds had potent inhibition effects with Ki values in the range of 13.57 ± 0.98 − 53.60 ± 6.81 µM against hCA I and 9.96 ± 1.02 − 46.35 ± 3.83 µM against hCA II in comparison to the acetazolamide (AZA) (Ki = 50.46 ± 6.17 µM for hCA I) and for hCA II (Ki = 41.31 ± 5.05 µM). Also, most of the compounds demonstrated potent inhibition ability towards AChE enzyme with Ki values 78.67–231.75 nM and compared to tacrine (TAC) as standard clinical inhibitor (Ki = 142.48 nM). Furthermore, ADMET analysis and molecular docking were calculated using the AChE, hCA I and hCA II enzyme proteins to correlate the data with the experimental data. In this work, recent applications of a stereoselective aza-Michael reaction as an efficient tool for of nitrogen-containing heterocyclic scaffolds and their useful to pharmacology analogs are reviewed and summarized.
FARMERS’ TRADITIONAL MAIZE HARVESTING AND STORAGE METHODS AND RESPONSE TO IMPROVED TECHNIQUES IN ONDO STATE, NIGERIA
Creators: name: Mafimisebi, Ojuotimi E.
name: Ojumu, Segun T.
name: Okunlola, James O.
name: Mafimisebi, Ojuotimi E.
name: Ojumu, Segun T.
name: Okunlola, James O.
Publisher: name: Unknown
Year: 2019
Subjects: Agribusiness

description: Presentation ID 15867
Collisionless dynamics of the condensate predicted in the random phase approximation
Creators: name: Navez, Patrick
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: From the microscopic theory, we derive a number conserving quantum kinetic equation, valid for a dilute Bose gas at any temperature, in which the binary collisions between the quasi-particles are mediated by phonon-like excitations (called ``condenson''). This different approach starts from the many-body Hamiltonian of a Boson gas and uses, in an appropriate way, the generalized random phase approximation. As a result, the collision term of the kinetic equation contains higher order contributions in the expansion in the interaction parameter. This different expansion shows up that a scattering involves the emission and the absorption of a phonon-like excitation. The major interest of this particular mechanism is that, in a regime where the condensate is stable, the collision process between condensed and non condensed particles is totally blocked due to a total annihilation of the mutual interaction potential induced by the condensate itself. As a consequence, the condensate is not constrained to relax and can be superfluid. Furthermore, a Boltzmann-like H-theorem for the entropy exists for this equation and allows to distinguish between dissipative and non dissipative phenomena (like vortices). We also illustrate the analogy between this approach and the kinetic theory for a plasma, in which the excitations correspond precisely to a plasmon. Finally, we show the equivalence of this theory with the non-number conserving Bogoliubov theory at zero temperature.
description: 20 pages, 1 figure
Which Factors Affect the Importance of Information Sources among U.S. Farmers?
Creators: name: Mohammadi, Zahra
name: Gunderson, Michael A.
name: Downey, Scott
name: Mohammadi, Zahra
name: Gunderson, Michael A.
name: Downey, Scott
Publisher: name: Unknown
Year: 2019
Subjects: Agribusiness

description: Presentation ID 15885
Diffusion and steady state distributions of flexible chemotactic enzymes
Creators: name: Agudo-Canalejo, Jaime
name: Golestanian, Ramin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Many experiments in recent years have reported that, when exposed to their corresponding substrate, catalytic enzymes undergo enhanced diffusion as well as chemotaxis (biased motion in the direction of a substrate gradient). Among other possible mechanisms, in a number of recent works we have explored several passive mechanisms for enhanced diffusion and chemotaxis, in the sense that they require only binding and unbinding of the enzyme to the substrate rather than the catalytic reaction itself. These mechanisms rely on conformational changes of the enzyme due to binding, as well as on phoresis due to non-contact interactions between enzyme and substrate. Here, after reviewing and generalizing our previous findings, we extend them in two different ways. In the case of enhanced diffusion, we show that an exact result for the long-time diffusion coefficient of the enzyme can be obtained using generalized Taylor dispersion theory, which results in much simpler and transparent analytical expressions for the diffusion enhancement. In the case of chemotaxis, we show that the competition between phoresis and binding-induced changes in diffusion results in non-trivial steady state distributions for the enzyme, which can either accumulate in or be depleted from regions with a specific substrate concentration.
description: 16 pages, 2 figures
Is People’s Daily Lifestyle Consistent with Their Food Purchasing Behavior?
Creators: name: Nian, Yefan
name: Shi, Lijia
name: Gao, Zhifeng
name: Zhao, Ruojin
name: Nian, Yefan
name: Shi, Lijia
name: Gao, Zhifeng
name: Zhao, Ruojin
Publisher: name: Unknown
Year: 2019
Subjects: Agribusiness

description: Presentation ID 16121
New empirical likelihood inference for the mean residual life with length-biased and right-censored data
Creators: name: Kangni Alemdjrodo
name: Yichuan Zhao
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: The mean residual life (MRL) function for a given random variable T is the expected remaining lifetime of T after a fixed time point t. It is of great interest in survival analysis, reliability, actuarial applications, duration modelling, etc. Liang, Shen, and He [‘Likelihood Ratio Inference for Mean Residual Life of Length-biased Random Variable’, Acta Mathematicae Applicatae Sinica, English Series, 32, 269–282] proposed empirical likelihood (EL) confidence intervals for the MRL based on length-biased right-censored data. However, their -2log(EL ratio) has a scaled chi-squared distribution. To avoid the estimation of the scale parameter in constructing confidence intervals, we propose a new empirical likelihood (NEL) based on i.i.d. representation of Kaplan–Meier weights involved in the estimating equation. We also develop the adjusted new empirical likelihood (ANEL) to improve the coverage probability for small samples. The performance of the NEL and the ANEL compared to the existing EL is demonstrated via simulations: the NEL-based and ANEL-based confidence intervals have better coverage accuracy than the EL-based confidence intervals. Finally, our methods are illustrated with a real data set.
Ultra Compact Dwarf galaxies in Abell 1689: a photometric study with the ACS
Creators: name: Mieske, S.
name: Infante, L.
name: Benitez, N.
name: Coe, D.
name: Blakeslee, J. P.
name: Zekser, K.
name: Ford, H.
name: Broadhurst, T. J.
name: Illingworth, G. D.
name: Hartig, G. F.
name: Clampin, M.
name: Ardila, D. R.
name: Bartko, F.
name: Bouwens, R. J.
name: Brown, R. A.
name: Burrows, C. J.
name: Cheng, E. S.
name: Cross, N. J. G.
name: Feldman, P. D.
name: Franx, M.
name: Golimowski, D. A.
name: Goto, T.
name: Gronwall, C.
name: Holden, B.
name: Homeier, N.
name: Kimble, R. A.
name: Krist, J. E.
name: Lesser, M. P.
name: Martel, A. R.
name: Menanteau, F.
name: Meurer, G. R.
name: Miley, G. K.
name: Postman, M.
name: Rosati, P.
name: Sirianni, M.
name: Sparks, W. B.
name: Tran, H. D.
name: Tsvetanov, Z. I.
name: White, R. L.
name: Zheng, W.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The properties of Ultra Compact Dwarf (UCD) galaxy candidates in Abell 1689 (z=0.183) are investigated, based on deep high resolution ACS images. A UCD candidate has to be unresolved, have i<28 (M_V26.8 mag, the radial and luminosity distribution of the UCD candidates can be explained well by Abell 1689's globular cluster (GC) system. For i<26.8 mag, there is an overpopulation of 15 +/- 5 UCD candidates with respect to the GC luminosity function. For i<26 mag, the radial distribution of UCD candidates is more consistent with the dwarf galaxy population than with the GC system of Abell 1689. The UCD candidates follow a color-magnitude trend with a slope similar to that of Abell 1689's genuine dwarf galaxy population, but shifted fainter by about 2-3 mag. Two of the three brightest UCD candidates (M_V ~ -17 mag) are slightly resolved. At the distance of Abell 1689, these two objects would have King-profile core radii of ~35 pc and r_eff ~300 pc, implying luminosities and sizes 2-3 times those of M32's bulge. Additional photometric redshifts obtained with late type stellar and elliptical galaxy templates support the assignment of these two resolved sources to Abell 1689. Our findings imply that in Abell 1689 there are at least 10 UCDs with M_V
description: 29 pages, 10 figures, accepted for publication in the October 2004 issue of the Astronomical Journal
Distributed Radiance Fields for Edge Video Compression and Metaverse Integration in Autonomous Driving
Creators: name: Šlapak, Eugen
name: Dopiriak, Matúš
name: Faruque, Mohammad Abdullah Al
name: Gazda, Juraj
name: Levorato, Marco
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: The metaverse is a virtual space that combines physical and digital elements, creating immersive and connected digital worlds. For autonomous mobility, it enables new possibilities with edge computing and digital twins (DTs) that offer virtual prototyping, prediction, and more. DTs can be created with 3D scene reconstruction methods that capture the real world's geometry, appearance, and dynamics. However, sending data for real-time DT updates in the metaverse, such as camera images and videos from connected autonomous vehicles (CAVs) to edge servers, can increase network congestion, costs, and latency, affecting metaverse services. Herein, a new method is proposed based on distributed radiance fields (RFs), multi-access edge computing (MEC) network for video compression and metaverse DT updates. RF-based encoder and decoder are used to create and restore representations of camera images. The method is evaluated on a dataset of camera images from the CARLA simulator. Data savings of up to 80% were achieved for H.264 I-frame - P-frame pairs by using RFs instead of I-frames, while maintaining high peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM) qualitative metrics for the reconstructed images. Possible uses and challenges for the metaverse and autonomous mobility are also discussed.
description: 6 pages, 6 figures, conference
TeV Colored Higgsinos in Alternative Grand Unified Theories
Creators: name: Cheung, Kingman
name: Cho, Gi-Chol
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, a type of GUT models with an extra dimension in AdS space can successfully solve the doublet-triplet problem, maintain proton stability, and allow the colored Higgs bosons and colored Higgsinos in the TeV mass region. We study the hadronic production and detection of these TeV colored Higgsinos and Higgs bosons. If the colored Higgsino is lighter than the colored Higgs boson, the colored Higgs boson will decay into a colored Higgsino and a gluino or a gravitino, and vice versa. The signatures would be stable massive charged particles with jets or missing energies.
description: RevTeX, 5 pages, 1 figure
Evolution of CIR storm on 22 July 2009
Creators: name: Perez, J.D.
name: Grimes, E.W.
name: Goldstein, J.
name: McComas, D.J.
name: Valek, P.
name: Billor, Nedret
Publisher: name: American Geophysical Union
Year: 2012
Subjects: CIR
THEMIS
TWINS
geomagnetic storms

description: Global images of ion intensities are deconvolved from TWINS ENA images during the main and recovery phase of a CIR storm on 22 July 2009. The global spatial ion images taken at different times, along with solar wind data, geomagnetic activity indices, geosynchronous orbit observations, and in situ measurements from the THEMIS mission provide a picture of the evolution of the ring current during both the main phase and early recovery phase of the storm. Major features of the evolution are consistent with expectations based upon time dependent geomagnetic indices, e. g., SYM/H and ASY/H, and geosynchronous orbit detection of dipolarizations from GOES 11 and 12. Direct comparisons are made with in situ THEMIS ESA and SST spectral measurements. The peak energy of the ion spectrum in the ring current is seen to decrease in the recovery phase. The time evolution of the ion energy spectra over the range from 2.5 to 97.5 keV at the spatial peaks of the ring current in the inner magnetosphere obtained from ENA images is presented for the first time.
A two dimensional position sensitive gas chamber with scanned charge transfer readout
Creators: name: Gomez, F.
name: Iglesias, A.
name: Lobato, R.
name: Mosquera, J.
name: Pardo, J.
name: Pena, J.
name: Pazos, A.
name: Pombar, M.
name: Rodriguez, A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We have constructed and tested a 2d position sensitive parallel-plate gas ionization chamber with scanned charge transfer readout. The scan readout method described here is based on the development of a new position dependent charge transfer technique. It has been implemented by using gate strips perpendicularly oriented to the collector strips. This solution reduces considerably the number of electronic readout channels needed to cover large detector areas. The use of a 25 micron thick kapton etched circuit allows high charge transfer efficiency with a low gating voltage, consequently needing a very simple commutating circuit. The present prototype covers 8 x 8 cm^2 with a pixel size of 1.27 x 1.27 mm^2. Depending on the intended use and beam characteristics a smaller effective pixel is feasible and larger active areas are possible. This detector can be used for X-ray or other continuous beam intensity profile monitoring.
description: 8 pages, 7 figures. Submitted to Nucl. Instr. and Meth. A
Drop-in Ready Jet Biofuel from Carinata: A Real Options Analysis of Processing Plant Investments
Creators: name: Zhao, Chong
name: Colson, Gregory J.
name: Karali, Berna
name: Philippidis, George
name: Zhao, Chong
name: Colson, Gregory J.
name: Karali, Berna
name: Philippidis, George
Publisher: name: Unknown
Year: 2019
Subjects: Agribusiness

description: Presentation ID 16263
Quality of life in DLD (Larson, 2024)
Creators: name: Larson, Caroline
Publisher: name: ASHA journals
Year: 2024
Subjects: classificationCode: 470402
subject: Child language acquisition
classificationCode: 520403
subject: Learning, motivation and emotion
classificationCode: 420110
subject: Speech pathology

description: Purpose: Developmental language disorder (DLD) is a lifelong condition associated with poorer outcomes than neurotypical peers, yet relatively little is known about long-term quality of life in DLD. This preliminary study adopts a neurodiversity-informed approach by exploring self-reported quality of life in an adolescent and young adult DLD sample, as well as linguistic and risk factors contributing to quality of life.Method: Participants were five individuals with DLD aged 12–20 years (M = 15.60, SD = 3.05). I administered two self-report quality-of-life scales, a language assessment, an experimental morphosyntax task, and measures of risk factors. Data were analyzed descriptively.Results: Participants generally reported positive views about their quality of life, although accessing accommodations and health services emerged as barriers. Relatively better grammaticality judgment performance appeared to be linked with poorer ratings of happiness and the ability to “be yourself.” Nonverbal ability represented a potential risk factor, although there may be a stronger cumulative role for risk factors.Conclusions: Participants with DLD reported relatively good quality of life. Exploratory findings suggest barriers to quality of life in some contexts, as well as roles for individual differences in language and risk factors. These descriptive findings should be examined in larger scale studies and may represent areas of consideration when clinicians address functional challenges that impact mental health and well-being in individuals with DLD.Supplemental Material S1. DLD CELF-5 scores.Supplemental Material S2. Group-level participant characteristics.Supplemental Material S3. Speech-language and specialized services history.Supplemental Material S4. Standards for reporting descriptive research methods checklist (O’Brien et al., 2014).Supplemental Material S5. By-participant socioeconomic and health-related risk factors.Supplemental Material S6. Quality of life questionnaire results; means and standard deviations reported.Supplemental Material S7. Correlations between quality of life and language measures.Larson, C. (2024). Exploring self-reported quality of life in developmental language disorder. Perspectives of the ASHA Special Interest Groups. Advance online publication. https://doi.org/10.1044/2024_PERSP-24-00122
Using Pre- and Post-Entry Data to Identify the Effect of Ethanol Expansion on the Spatial Pattern of Corn Prices: A Study in Indiana
Creators: name: Jung, Jinho
name: Sesmero, Juan Pablo
name: Siebert, Ralph
name: Jung, Jinho
name: Sesmero, Juan Pablo
name: Siebert, Ralph
Publisher: name: Unknown
Year: 2019
Subjects: Agribusiness

description: Presentation ID 16378