Additional file 1 of Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK
Creators: name: Henderson, Alasdair D.
name: Adesanya, Elizabeth
name: Mulick, Amy
name: Matthewman, Julian
name: Vu, Nhung
name: Davies, Firoza
name: Smith, Catherine H.
name: Hayes, Joseph
name: Mansfield, Kathryn E.
name: Langan, Sinéad M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health

description: Additional file 1: Methods S1. additional information on cohort design, statistical methods and computer software [77–79]. Table S1. Full baseline characteristics of people with and without eczema at cohort entry for anxiety/depression. Table S2. Full baseline characteristics of people with and without psoriasis at cohort entry for anxiety/depression. Table S3. Data availability for quintiles of the Carstairs index of deprivation. Table S4. Characteristics of time updated covariates throughout the entire study period. Table S5. Person years under follow up in adults with and without eczema by individual-level characteristics. Table S6. Person years under follow up in adults with and without psoriasis by individual-level characteristics. Table S7. Baseline characteristics of those with and without complete data, comparing adults with and without eczema. Table S8. Baseline characteristics of those with and without complete data, comparing adults with and without psoriasis. Table S9. Hazard ratios from Cox regression models for the association between inflammatory skin conditions and anxiety or depression. Table S10. All parameter estimates from Cox modelling of the association between eczema and anxiety. Table S11. All parameter estimates from Cox modelling of the association between eczema and depression. Table S12. All parameter estimates from Cox modelling of the association between psoriasis and anxiety. Table S13. All parameter estimates from Cox modelling of the association between psoriasis and depression. Table S14. Analysis of individuals with/without a consultation with their GP either 1-year or 3-years before study entry. Table S15. Estimates of the time-varying hazard ratios for the association between eczema/psoriasis and anxiety/depression at multiple time-points following study entry. Table S16. Number of people exposed to eczema, psoriasis or both skin conditions in the overall exposed cohorts. Figure S1. Directed acyclic graph for the association between eczema and anxiety or depression. Figure S2. Participant flowcharts. Figure S3. Percentage of missing data in the both the eczema and psoriasis cohorts. Figure S4. Percentage of individuals with eczema at study entry with a record for a diagnosis or prescription for sleeping problems by varying levels of eczema severity. Figure S5. Sensitivity analyses: Hazard ratios for the association between eczema/psoriasis. and anxiety/depression from stratified Cox models. Figure S6. Schoenfeld residuals to test the proportional hazards assumption for the association between eczema /psoriasis and anxiety/depression. Figure S7. Exploring non-constant hazard ratios for the association between inflammatory skin conditions and anxiety or depression by including a linear interaction with time. Figure S8. Schoenfeld residuals to check the proportional hazards assumption for the association between eczema/psoriasis severity and anxiety/depression. Figure S9. Estimated hazard ratios for the total effect of inflammatory skin conditions on anxiety or depression, modified by several pre-specified effect modifiers.