cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Effects of the H-NS Protein on PhoP-dependent Transcriptional Regulation of the mgtCBRU-cigR Operon in Salmonella enterica serovar Typhimurium
Creators: name: Marks-Burns, Jazmin L
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Bacteriology
Microbial genetics
Microbiology not elsewhere classified

description: PhoQP is a two-component system that regulates the transcription of ~5% of the genes of Salmonella enterica. The membrane-bound PhoQ protein is phosphorylated in response to low extracellular Mg2+ concentration, acid pH, and a number of antimicrobial peptides. The inorganic phosphate bound to PhoQ is transferred to PhoP, which according to the classical model, acts as a typical transcriptional activator of its target genes. However, Will et al. (doi.org/10.1038/ncomms6270) proposed an alternate “counter-silencing” model, according to which genes in the PhoP regulon that were acquired by Salmonella via horizontal transfer are repressed by the generalized DNA-binding protein H-NS at high [Mg2+] and are induced at low [Mg2+] because the phosphorylated PhoP displaces the H-NS from the promoters and lifts repression. We evaluated this model by examining the transcriptional regulation of the mgtCBRU-cigR operon, which encodes the virulence protein MgtC and the Mg2+ transport protein MgtB and is in the SPI-3 pathogenesis island that has been acquired by Salmonella via horizontal transfer. Our main finding was that in the non-pathogenic strain of S. Typhimurium (LT2), induction of the mgtCBRU-cigR operon by Mg2+ limitation requires a functional PhoP protein, regardless of the presence or absence of H-NS. Interestingly, the pathogenic strain of S. Typhimurium (ATCC 14028s) revealed PhoP-independent transcription in the absence of H-NS, but only under inducing conditions. Thus, our results do not support the counter-silencing model and are consistent with the canonical view that PhoP is needed as a transcriptional activator of genes in the PhoP regulon.
Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites.
Creators: name: Haberman, Nejc
name: Digby, Holly
name: Faraway, Rupert
name: Cheung, Rebecca
name: Chakrabarti, Anob M
name: Jobbins, Andrew M
name: Parr, Callum
name: Yasuzawa, Kayoko
name: Kasukawa, Takeya
name: Yip, Chi Wai
name: Kato, Masaki
name: Takahashi, Hazuki
name: Carninci, Piero
name: Vernia, Santiago
name: Ule, Jernej
name: Sibley, Christopher R
name: Martinez-Sanchez, Aida
name: Lenhard, Boris
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Stem Cells
subject: Stem Cells
classificationCode: Ecology,Evolution & Ethology
subject: Ecology,Evolution & Ethology
classificationCode: Gene Expression
subject: Gene Expression
classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics

description: The 3' untranslated region (3'UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped 5' ends of mRNAs, additionally reveals a large number of apparently 5' capped RNAs derived from locations within the body of the transcript, including 3'UTRs. Here, we provide direct evidence that these 3'UTR-derived RNAs are indeed capped and widespread in mammalian cells. By using a combination of AGO2 enhanced individual nucleotide resolution UV crosslinking and immunoprecipitation (eiCLIP) and CAGE following siRNA treatment, we find that these 3'UTR-derived RNAs likely originate from AGO2-binding sites, and most often occur at locations with G-rich motifs bound by the RNA-binding protein UPF1. High-resolution imaging and long-read sequencing analysis validate several 3'UTR-derived RNAs, showcase their variable abundance and show that they may not co-localise with the parental mRNAs. Taken together, we provide new insights into the origin and prevalence of 3'UTR-derived RNAs, show the utility of CAGE-seq for their genome-wide detection and provide a rich dataset for exploring new biology of a poorly understood new class of RNAs.
Path Following Control of Automated Vehicle Considering Model Uncertainties External Disturbances and Parametric Varying
Creators: name: Shen, Dan
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Control engineering, mechatronics and robotics not elsewhere classified

description: Automated Vehicle Path Following Control (PFC) is an advanced control system that can regulate the vehicle into a collision-free region in the presence of other objects on the road. Common collision avoidance functions, such as forward collision warning and automatic emergency braking, have recently been developed and equipped on production vehicles. However, it is impossible to develop a perfectly precise vehicle model when the vehicle is driving. The most PFC did not consider uncertainties in the vehicle model, external disturbances, and parameter variations at the same time. To address the issues associated with this important feature and function in autonomous driving, a new vehicle PFC is proposed using a robust model predictive control (MPC) design technique based on matrix inequality and the theoretical approach of the hybrid $\&$ switched system. The proposed methodology requires a combination of continuous and discrete states, e.g. regulating the continuous states of the AV (e.g., velocity and yaw angle) and discrete switching of the control strategy that affects the dynamic behaviors of the AV under different driving speeds. Firstly, considering bounded model uncertainties, norm-bounded external disturbances, the system states and control matrices are modified. In addition, the vehicle time-varying longitudinal speed is considered, and a vehicle lateral dynamic model based on Linear Parameter Varying (LPV) is established by utilizing a polytope with finite vertices. Then the Min-Max robust MPC state feedback control law is obtained at every timestamp by solving a set of matrix inequalities which are derived from Lyapunov stability and the minimization of the worst-case in infinite-horizon quadratic objective function. Compared to adaptive MPC, nonlinear MPC, and cascade LPV control, the proposed robust LPV MPC shows improved tracing accuracy along vehicle lateral dynamics. Finally, the state feedback switched LPV control theory with separate Lyapunov functions under both arbitrary switching and average-dwell-time (ADT) switching conditions are studied and applied to cover the path following control in full speed range. Numerical examples, tracking effectiveness, and convergence analysis are provided to demonstrate and ensure the control effectiveness and strong robustness of the proposed algorithms.
ЛАБОРАТОРНАЯ И ПОЛЕВАЯ ВСХОЖЕСТЬ СЕМЯН ЛЕТНИХ СИДЕРАТОВ
Creators: name: Асракулов, Аббос
Publisher: name: Zenodo
Year: 2025

description: В этой статье представлены материалы о лабораторной и полевой всхожести семян сидератных культур. Лабораторная всхожесть фасоли составила 99%, сахарной кукурузы – 96%, перко – 95%. По полевой всхожести было отмечено, что бобовая культура и её состав богаты белком, поэтому полевая всхожесть была выше по сравнению с другими сидератами.
Additional file 1 of Cost-Effectiveness of Treatments for Musculoskeletal Conditions Offered by Physiotherapists: A Systematic Review of Trial-Based Evaluations
Creators: name: Baumbach, Linda
name: Feddern, Wiebke
name: Kretzler, Benedikt
name: Hajek, André
name: König, Hans-Helmut
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Details on the PubMed search.
THE DIFFERENTIAL IMPACT OF FILIAL RESPONSIBILITY ON LATINX YOUTH INTERNALIZING AND EXTERNALIZING PROBLEMS
Creators: name: Herrera, Fabiola
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Psychology of ageing

description: Latinx adolescents from immigrant families often face more challenges than their peers due to simultaneously navigating the demands of two cultures. Many Latinx children are expected to contribute to the household in multiple ways, such as engagement in tasks like filial responsibility, which can impact their development. Filial responsibility is composed of three dimensions 1) instrumental caregiving (e.g., cleaning, translating, and paying bills), 2) emotional caregiving (e.g., providing emotional support to the family), and 3) perceived unfairness (i.e., feelings about whether caregiving tasks are fair). The present study aimed to examine the dimensions of filial responsibility and their relations to internalizing and externalizing problems in Latinx youth and whether perceived unfairness acted as a mediator. Participants were 176 Latinx youth (Mage = 15.51 years, 66% female). Our SEM model demonstrated that filial responsibility (instrumental and emotional caregiving) did not have a mediating effect on perceived unfairness in youth adjustment. Evidence was found for filial responsibility (emotional and instrumental caregiving) being differentially related to youth adjustment directly over time. Instrumental caregiving at T1 negatively predicted internalizing behaviors at T2, while T1 emotional caregiving positively predicted both internalizing and externalizing behaviors at T2 (controlling for prior youth adjustment). Results demonstrate the importance of independently examining the impact of instrumental and emotional caregiving on youth adjustment. Future studies should assess the impact of caregiving tasks on other youth outcomes such as academic success.
sj-docx-2-chi-10.1177_17423953211049751 - Supplemental material for Self-efficacy in disadvantaged communities: Perspectives of healthcare providers and clients
Creators: name: Hardman, Ruth
name: Begg, Stephen
name: Spelten, Evelien
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care
subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-2-chi-10.1177_17423953211049751 for Self-efficacy in disadvantaged communities: Perspectives of healthcare providers and clients by Ruth Hardman, Stephen Begg and Evelien Spelten in Chronic Illness
sj-docx-2-rse-10.1177_07419325211047956 – Supplemental material for Examining the Likelihood of Parents’ Homework Involvement With Elementary-Aged Students With Individualized Education Plans
Creators: name: Womack, Tyler A.
name: Johnson, Austin H.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-2-rse-10.1177_07419325211047956 for Examining the Likelihood of Parents’ Homework Involvement With Elementary-Aged Students With Individualized Education Plans by Tyler A. Womack and Austin H. Johnson in Remedial and Special Education
Additional file 2 of Cost-Effectiveness of Treatments for Musculoskeletal Conditions Offered by Physiotherapists: A Systematic Review of Trial-Based Evaluations
Creators: name: Baumbach, Linda
name: Feddern, Wiebke
name: Kretzler, Benedikt
name: Hajek, André
name: König, Hans-Helmut
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2. Overview of excluded full text articles.
THE MAIN PEDAGOGICAL ASPECTS OF THE FORMATION OF COLLABORATIVE SKILLS OF STUDENTS BASED ON MULTI-VECTOR PEDAGOGICAL APPROACHES IN HIGHER EDUCATION
Creators: name: Turemuratova, Aziza
name: Atabaeva, Khurshıda
Publisher: name: Zenodo
Year: 2024

description: Collaboratіve problem solvіng іnvolves two dіfferent constructs—collaboratіon and problem solvіng. The assumptіon іs that collaboratіon for a group task іs essentіal because some problem-solvіng tasks are too complex for an іndіvіdual to work through alone or the solutіon wіll be іmproved from the joіnt capacіtіes of a team. People vary іn the іnformatіon, expertіse, and experіences that they can brіng to bear іn order to joіntly solve a partіcular problem.
sj-docx-3-rse-10.1177_07419325211047956 – Supplemental material for Examining the Likelihood of Parents’ Homework Involvement With Elementary-Aged Students With Individualized Education Plans
Creators: name: Womack, Tyler A.
name: Johnson, Austin H.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-3-rse-10.1177_07419325211047956 for Examining the Likelihood of Parents’ Homework Involvement With Elementary-Aged Students With Individualized Education Plans by Tyler A. Womack and Austin H. Johnson in Remedial and Special Education
Image Steganography Using Deep Learning Techniques
Creators: name: Guzman, Anthony Rene
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Image processing
Computer graphics

description: Digital image steganography is the process of embedding information withina cover image in a secure, imperceptible, and recoverable way.The three main methods of digital image steganography are spatial, transform, and neural network methods. Spatial methods modify the pixel valuesof an image to embed information, while transform methods embed hidden information within the frequency of the image.Neural network-based methods use neural networks to perform the hiding process, which is the focus of the proposed methodology. This research explores the use of deep convolutional neural networks (CNNs) in digital image steganography. This work extends an existing implementation that used a two-dimensional CNN to perform the preparation, hiding, and extraction phases of the steganography process. The methodology proposed in this research, however, introduced changes into the structure of the CNN and used a gain function based on several image similarity metrics to maximize the imperceptibility between a cover and steganographic image. The performance of the proposed method was measuredusing some frequently utilized image metrics such as structured similarity index measurement (SSIM), mean square error (MSE), and peak signal to noise ratio (PSNR). The results showed that the steganographic images produced by the proposed methodology areimperceptible to the human eye, while still providing good recoverability. Comparingthe results of the proposed methodologyto theresults of theoriginalmethodologyrevealed that our proposed network greatly improved over the base methodology in terms of SSIM andcompareswell to existing steganography methods.
ScaDS.AI Meetup #2 2025: AI Insights on local LLMs
Creators: name: Welz, Oliver
Publisher: name: Zenodo
Year: 2025

description: Presentation on the AI insights on local Large Laguage Models (LLMs) at the Meetup #2 2025 at ScaDS.AI.

The presentation covers the basics of LLMs (transformer architecture), open source models and how to run them locally on your (own) hardware.
La educación ambiental como equilibrio entre turismo y la conservación del ecosistema de Playa Santa Lucia
Creators: name: Alberto Rodríguez Fernández
name: Amancia Rodríguez Pérez
name: Yania Gómez Victoria
name: Gilsa Reyes Montenegro
name: Yoima Lima Olazabal
Publisher: name: Zenodo
Year: 2025

description: La capacitación continua y planificada en correspondencia con las necesidades de aprendizaje referente al ecosistema marino y costero en Playa Santa Lucia, es el aporte de esta investigación que forma parte del resultado número seis del proyecto territorial “Turismo azul resiliente en un contexto de cambio climático en el destino Playa Santa Lucía”. Los resultados del diagnóstico específico por cada grupo meta: trabajadores, directivos, líderes comunitarios, población residente y en edad escolar que interactúan con los recursos naturales ha permitido concebir la participación de todos en el mejoramiento del entorno natural. La creación de Círculos de Interés en los centro educacionales del Consejo Popular, la relación con la carrera de Turismo en el Centro Universitario de Nuevitas y la concepción de acciones de capacitación en entidades turísticas son las vías de implementar lo diseñado en el Programa de Intervención Educativa, los resultados en la población en edad escolar ha recibido evaluaciones favorables de investigadores del Instituto de Ciencias del Mar (ICMAR), Centro de Investigaciones del Medio Ambiente en Camagüey (CIMAC) y Gobierno territorial.

Palabras claves: Turismo   azul   resiliente, capacitación, diagnóstico, programa de intervención educativa.
PEDAGOGICAL ANALYSIS OF THE FORMATION OF COLLABORATIVE SKILLS OF STUDENTS BASED ON MULTI-VECTOR PEDAGOGICAL APPROACHES IN EDUCATION
Creators: name: Turemuratova, Aziza
name: Ruzimova, Mahliyo
Publisher: name: Zenodo
Year: 2024

description: Collaboratіon skіlls are skіlls that students must possess to face the challenges of the 21st century. Collaboratіon skіlls do not only play a role іn learnіng but are іndіspensable for solvіng lіfe problems. The purpose of thіs thesіs was to іdentіfy the collaboratіon skіlls of hіgh school students іn scіence learnіng. Thіs non-experіmental survey research іnvolved 226 hіgh school students. Data collectіon was carrіed out by observatіon wіth observatіon guіdelіnes.
sj-pdf-1-jba-10.1177_08853282211046800 – Supplemental Material for Pressure-compacted and spider silk–reinforced fibrin demonstrates sufficient biomechanical stability as cardiac patch in vitro
Creators: name: Bobylev, Dmitry
name: Wilhelmi, Mathias
name: Lau, Skadi
name: Klingenberg, Melanie
name: Mlinaric, Markus
name: Petená, Elena
name: Helms, Florian
name: Hassel, Thomas
name: Haverich, Axel
name: Horke, Alexander
name: Böer, Ulrike
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental Material, sj-pdf-1-jba-10.1177_08853282211046800 for Pressure-compacted and spider silk–reinforced fibrin demonstrates sufficient biomechanical stability as cardiac patch in vitro by Dmitry Bobylev, Mathias Wilhelmi, Skadi Lau, Melanie Klingenberg, Markus Mlinaric, Elena Petená, Florian Helms, Thomas Hassel, Axel Haverich, Alexander Horke and Ulrike Böer in Journal of Biomaterials Applications
sj-docx-1-mdm-10.1177_0272989X211028563 – Supplemental material for Preparing Patients with Early Stage Prostate Cancer to Participate in Clinical Appointments Using a Shared Decision Making Training Video
Creators: name: Scherr, Karen
name: Delaney, Rebecca K.
name: Ubel, Peter
name: Kahn, Valerie C.
name: Hamstra, Daniel
name: Wei, John T.
name: Fagerlin, Angela
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-mdm-10.1177_0272989X211028563 for Preparing Patients with Early Stage Prostate Cancer to Participate in Clinical Appointments Using a Shared Decision Making Training Video by Karen Scherr, Rebecca K. Delaney, Peter Ubel, Valerie C. Kahn, Daniel Hamstra, John T. Wei and Angela Fagerlin in Medical Decision Making
AFRICAN RELIGIOUS PRACTICES AND THEIR ROLE IN MITIGATING CONFLICT
Creators: name: Grace, Akinyi Anyango
name: Samuel, Otieno Nyong'o
Publisher: name: Continental Journal
Year: 2024
Subjects: Africa, Conflict, Nation-building, Ethnic tensions, Peace-building

description: The pursuit of nation-building dreams persists in certain regions of Africa; however, recent years have witnessed fractures within many African states, primarily stemming from conflicts. These conflicts have led to brutal battles among various African groups, resulting in devastating consequences. Examples include the longstanding conflicts among the Karamajong of Uganda and the Pokots and Marakwets in Kenya, as well as the Muslim-Christian conflict in Sudan and the genocides in Rwanda and Burundi.

This paper examines the complexities of conflict dynamics in Africa, focusing on the socio-political tensions and violent confrontations that have plagued the continent in recent years. Drawing upon historical and contemporary examples, such as the inter-ethnic clashes in Uganda and Kenya and the religious strife in Sudan, the paper explores the multifaceted roots of conflict and its profound impact on African societies.

By delving into the underlying causes and consequences of these conflicts, the paper aims to contribute to a deeper understanding of the challenges facing African nations in their quest for stability and nation-building. It underscores the urgent need for effective conflict resolution mechanisms and sustainable peace-building efforts to address the underlying grievances and promote reconciliation and development in the region.
Identifying Agricultural Retailers' Gaps in Understanding of the Value Proposition for Large Commercial Producers
Creators: name: Utech, Hailey Grace
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Agricultural economics

description: In order for agricultural retailers to remain successful in a volatile market, it is imperative that they understand the needs and buying behaviors of their producers. These producers can be divided into four buying segments: the Economic buyer, the Agronomic buyer, the Business buyer, and the Performance buyer by identifying similar buying characteristics. The retailer’s ability to correctly predict their producers into the correct buying segment would allow them to optimally market to individual producers offering a consistent value proposition across all farms. This research uses cluster analysis to segment the agricultural market, multinomial logistic regression models to extract the variables that determined cluster classifications, and accuracy measures from a multilevel confusion matrix to assess retailers’ ability to classify their producers into the correct buying segment. Retailers predicted 70% of their producers into the correct segment. However, the accuracies differed across each segment leaving opportunity for an inconsistent value proposition across all segments.
Additional file 3 of Cost-Effectiveness of Treatments for Musculoskeletal Conditions Offered by Physiotherapists: A Systematic Review of Trial-Based Evaluations
Creators: name: Baumbach, Linda
name: Feddern, Wiebke
name: Kretzler, Benedikt
name: Hajek, André
name: König, Hans-Helmut
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3. Evaluation of the study quality with the Consensus on Health Economic Criteria checklist.
sj-pdf-1-jao-10.1177_03913988211047604 – Supplemental material for Clinical outcomes of severe COVID-19 patients receiving early VV-ECMO and the impact of pre-ECMO ventilator use
Creators: name: Kunavarapu, Chandra
name: Yeramaneni, Samrat
name: Melo, Jairo
name: Sterling, Rachel K
name: Huskey, Lindsey C
name: Sears, Lindsay
name: Burch, Charles
name: Rodriguez, Steve M
name: Habib, Phillip J
name: Triana, Fernando
name: DellaVolpe, Jeffrey
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-pdf-1-jao-10.1177_03913988211047604 for Clinical outcomes of severe COVID-19 patients receiving early VV-ECMO and the impact of pre-ECMO ventilator use by Chandra Kunavarapu, Samrat Yeramaneni, Jairo Melo, Rachel K Sterling, Lindsey C Huskey, Lindsay Sears, Charles Burch, Steve M Rodriguez, Phillip J Habib, Fernando Triana and Jeffrey DellaVolpe in The International Journal of Artificial Organs
Additional file 1 of Geomorphic changes after the 2021 Central European flood in the Ahr Valley by LiDAR-based differences
Creators: name: Steinritz, Vanessa
name: Bellanova, Piero
name: Schmidt, Bernd
name: Schüttrumpf, Holger
name: Schwarzbauer, Jan
name: Reicherter, Klaus
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Figure S1. Profile A-B Area 1. Figure S2. Profile C-D Area 2. Figure S3. Profile A-B Area 3. Figure S4. Profile C-D Area 3. Figure S5. Profile A-B Area 4. Figure S6. Profile E–F Area 4. Figure S7. Profile A-B Area 5.
NONINVASIVE CHARACTERIZATION AND DEVELOPMENT OF IN SITU FORMING IMPLANTS FOR USE AS A LOCAL PANCREATIC CANCER THERAPY
Creators: name: Hopkins, Kelsey A
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Biomaterials
Biomedical engineering not elsewhere classified

description: Pancreatic ductal adenocarcinoma is an especially deadly disease having the lowest 5-year survival rate of any major cancer at just 11%. As in many cancers, systemically-delivered chemotherapy forms the backbone of clinical treatment. However, limitations of systemic delivery exacerbated by the unique desmoplastic and avascular microenvironment surrounding the pancreatic tumor cells result in the failed efficacy of current treatments. The high stromal content in the microenvironment, which is especially overabundant in hyaluronic acid, is thought to physically impede drug perfusion into the tissue. Thus, there is clearly a critical need to develop novel treatments for pancreatic ductal adenocarcinoma that can overcome these drug delivery barriers. Long-acting injectable implants offer an attractive drug delivery method that can provide sustained drug release directly at the local targeted site, rather than transient, systemic release. Here we use in situ forming implants (ISFIs), which are a low-viscosity solution outside of the body but transition into a solid drug-eluting depot after injection into an aqueous environment. Our objective is to develop and characterize an ISFI that can provide sustained release of bioactive hyaluronidase for use as an intratumoral injection to degrade hyaluronic acid in pancreatic tumors. This work was accomplished in four aims. First, a method was developed using diffusion-weighted MRI for noninvasive characterization of the implants. Second, because hyaluronidase is a protein drug, we studied factors affecting protein release from ISFIs, focusing on external factors of the injection site. Third, we showed that basic salt additives can be used to neutralize the acidic environment created by the implants which may improve protein stability. Finally, we formulated an implant to provide sustained release of hyaluronidase and demonstrated retention of its bioactivity both in vitro and ex vivo.
sj-pdf-1-imr-10.1177_03000605211049946 - Supplemental material for Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients
Creators: name: Luo, Junhua
name: Xu, Jinming
name: Ou, Longhua
name: Zhou, Yingchen
name: Yun, Haichao
name: Yang, Yu
name: Wu, Xionghui
name: Wang, Yan
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605211049946 for Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients by Junhua Luo, Jinming Xu, Longhua Ou, Yingchen Zhou, Haichao Yun, Yu Yang, Xionghui Wu and Yan Wang in Journal of International Medical Research
sj-docx-1-dst-10.1177_19322968211050649 – Supplemental material for Relationships Between Socioeconomic Status, Insurance Coverage for Diabetes Technology and Adverse Health in Patients With Type 1 Diabetes
Creators: name: Everett, Estelle M.
name: Wisk, Lauren E.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified

description: Supplemental material, sj-docx-1-dst-10.1177_19322968211050649 for Relationships Between Socioeconomic Status, Insurance Coverage for Diabetes Technology and Adverse Health in Patients With Type 1 Diabetes by Estelle M. Everett and Lauren E. Wisk in Journal of Diabetes Science and Technology
CHINESE GOVERNMENT MANAGES POLITICAL CRISES ON SOCIAL MEDIA WITH ENTERTAINMENT-ORIENTED NARRATIVES
Creators: name: Fa, Bingxin
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Comparative government and politics
Government and politics of Asia and the Pacific

description: This dissertation identifies an important strategy the Chinese Communist Party (CCP) uses to manage crisis events online: the entertainment-oriented narrative. It appears in three forms: (1) likening the reality to an unreal TV show or a fictional scene; (2) using cute emojis and anthropomorphism to represent crisis-related concepts; and (3) framing the country as a pop star (idol) and encourage citizens to defend it regardless. The CCP uses these tactics to trivialize the importance of crises, deflect public criticism, and discourage the public from critical thinking. Case studies show that this strategy has become a regular practice of the government that worked effectively when the crises do not seriously and massively affect local citizens' lives.
title: Environmentally optimized microreactor design through Life Cycle Assessment
Creators: name: Zschieschang, Eva
name: Pfeifer, Peter
name: Schebek, Liselotte
Publisher: name: De Gruyter
Year: 2025

description: Design decisions made in early R&D of a new technology ultimately determine its future environmental performance. Owing to the awareness of environmental impacts of technologies during their life cycle, the optimization of their design seems fundamental to develop more sustainable technologies. Using the example of a microstructured reactor for gas to liquid fuel conversion in early R&D, the Modular Server-Client-Server methodology for combining technical optimization with parametric Life Cycle Impact Assessment was used to analyze different design and manufacturing options. Two structuring fabrication techniques for metal foils were compared for several microreactor designs with respect to their ecological impact. Furthermore, improvable and non-improvable technical parameters regarding environmental impact, the impact of each fabrication step and within one fabrication step were analyzed. In conclusion, our analyses provide helpful information allowing for environmentally optimized design considerations in early R&D of a microreactor.
sj-pdf-1-com-10.1177_21674795211043551 – Supplemental Material for Consumer Response to Patriotic Ads for Domestic Versus Foreign Brands in Contexts of International Sporting Events: The Role of National Identity Activation and Group Emotion
Creators: name: Yoo, Jinyoung Jinnie
name: Choi, Dongwon
name: Bang, Hyejin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental Material, sj-pdf-1-com-10.1177_21674795211043551 for Consumer Response to Patriotic Ads for Domestic Versus Foreign Brands in Contexts of International Sporting Events: The Role of National Identity Activation and Group Emotion by Jinyoung Jinnie Yoo, Dongwon Choi and Hyejin Bang in Communication & Sport
CHILDREN'S RIGHTS IN INDIA: ASSESSING THE EFFECTIVENESS OF CHILD LABOR LAWS AND LEGAL SAFEGUARDS
Creators: name: Shahnaz, Parveen Ahmad
Publisher: name: Continental Journal
Year: 2024
Subjects: Child labor, Developing economies, Africa, Asia, International Labour Organization (ILO)

description: Child labor remains a widespread issue globally, with developing economies, particularly in Africa and Asia, bearing the brunt of its serious consequences. While industrialized nations have made significant strides in reducing child labor, the problem persists in many regions, posing significant challenges to child welfare and development. Africa and Asia collectively account for over ninety percent of the global child labor force, with a higher proportion of African children engaged in labor compared to other regions. According to estimates by the International Labour Organization (ILO), approximately 246 million children aged five to fourteen were economically active in 2005, with the majority located in Asia (61%), followed by Africa (32%), and Latin America (7%).

This paper explores the pervasive nature of child labor in developing economies, focusing on the socio-economic factors contributing to its prevalence and the detrimental impact on children's well-being and future prospects. Drawing upon data from the ILO and other sources, it examines the regional disparities in child labor prevalence and the underlying drivers fueling its persistence in Africa and Asia.

By highlighting the scale and scope of the problem, the paper underscores the urgent need for concerted efforts to address the root causes of child labor and implement effective interventions to protect children's rights and ensure their access to education and opportunities for a better future
sj-pdf-2-tar-10.1177_17534666211049739 – Supplemental material for The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study
Creators: name: Wang, Lin
name: Chen, Jun
name: Zhao, Jun
name: Li, Feng
name: Lu, Shuihua
name: Liu, Ping
name: Liu, Xu-hui
name: Huang, Qin
name: Wang, He
name: Xu, Qing nian
name: Liu, Xiaomin
name: Yu, Shijun
name: Liu, Li
name: Lu, Hongzhou
Publisher: name: SAGE Journals
Year: 2021
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-2-tar-10.1177_17534666211049739 for The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study by Lin Wang, Jun Chen, Jun Zhao, Feng Li, Shuihua Lu, Ping Liu, Xu-hui Liu, Qin Huang, He Wang, Qing nian Xu, Xiaomin Liu, Shijun Yu, Li Liu and Hongzhou Lu in Therapeutic Advances in Respiratory Disease
DEVELOPING STUDENTS' SENSE OF RESPONSIBILITY FOR THE ENVIRONMENT
Creators: name: Ru`ziyeva, Nazira
name: Murodova, Shakhnoza
Publisher: name: Zenodo
Year: 2024

description: This article discusses the current issue, namely, the importance of educating students in a sense of environmental awareness, society and general responsibility, and the importance of preserving the purity of the atmosphere as an important source for creating a healthy environment in the future.
Additional file 1 of HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review
Creators: name: Gotora, Piwai Terry
name: van der Sluis, Rencia
name: Williams, Monray Edward
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1. Database search terms.
sj-pdf-2-tva-10.1177_15248380211046968 – Supplemental Material for A Systematic Review of Culturally Competent Family Violence Responses to Women in Primary Care
Creators: name: Pokharel, Bijaya
name: Yelland, Jane
name: Hooker, Leesa
name: Taft, Angela
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-2-tva-10.1177_15248380211046968 for A Systematic Review of Culturally Competent Family Violence Responses to Women in Primary Care by Bijaya Pokharel, Jane Yelland, Leesa Hooker and Angela Taft in Trauma, Violence, & Abuse
Etanercept therapy for difficult-to-control erythrodermic psoriasis. A case report
Creators: name: Diana Maria Ibarra Tostado M.D.
name: Juan Manuel Bernardino Lopez M.D.
name: Maria Lourdes Ochoa Campollo M.D.
name: Valeria Contreras Oceguera M.D.
name: Mariany Hernandez Sanchez M.D.
Publisher: name: Zenodo
Year: 2024

description: Background: Erythrodermic Psoriasis affects less than 2% of Psoriasis patients and is defined by erythema and hyperkeratosis that affects at least 90% of the total body surface. Due to the extensive skin involvement, patients may present systemic symptoms, making this pathology a risk to life. The case of a 68-year-old female patient with Erythrodermic Psoriasis is presented, who had intolerance to conventional treatments and multiple comorbidities. The patients history reveals a progression of two months with the presence of diffuse erythema, peeling, pruritus, skin ardor, fever, chills and general discomfort. Physical examination reveals erythematous lesions, desquamative with hyperkeratosis that converge with each other, causing pain and intense itching. Skin biopsies confirmed the presumptive diagnosis. IL-6 and IL-8 participate in hyperkeratosis and formation of new vessels; their elevated levels are related to the severity of the pathology. ELISA and RT-qPCR results have shown that Etanercept decreased the production of these cytokines. Following a comprehensive analysis, management with Etanercept was initiated, resulting in significant clinical improvement.  The use of these agents should be individualized and tailored to each patient's characteristics.
LLMicroscopilot: An LLM assistant for scanning tunneling and transmission electron microscopy measurements
Creators: name: Cojal Gonzalez, José D.
name: Zhao, Meng
name: Schloz, Marcel
name: Shabih, Sherjeel
name: Koch, Christoph
name: Palma, Carlos-Andres
Publisher: name: Zenodo
Year: 2024

description: A key challenge in experimental high-resolution microscopy is the real-time interpretation of the observed images in conjunction with the parameters adjusted by the experimenter during data acquisition, e.g. to obtain a certain contrast. The parameter space of candidate structures, experimental parameters, and resulting image contrast can be vast and complex, often requiring a scientist who is well-trained in performing image simulations and a lot of trial and error to come up with a plausible interpretation of the observation. To make such expert simulations accessible to anyone, we introduce LLMicroscopilot, a chatbot tool powered by a large language model (LLM), that searches materials databases for suitable structures and simulates various types of microscopy images from them, without requiring the user to know how to operate either the database search, or the simulation software. It recommends suitable simulation parameters for obtaining high-quality results, recovers from errors in code execution, and refines results in dialog with the user. We demonstrate the capability of Microscopilot to operate transmission electron microscopy (TEM) and scanning tunneling microscopy (STM) simulation software back-ends, and more. Additionally, we highlight the potential for mining the memory of microscopy parameters that this tool is capable of building up, e.g. by recommending parameters that have led to accepted results in previous uses.

 

This work is funded by the NFDI consortium FAIRmat - Deutsche Forschungsgemeinschaft (DFG) - Project 460197019
HIGH-THROUGHPUT CALCULATIONS AND EXPERIMENTATION FOR THE DISCOVERY OF REFRACTORY COMPLEX CONCENTRATED ALLOYS WITH HIGH HARDNESS
Creators: name: Hernandez, Austin M
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Metals and alloy materials
Aerospace materials

description: Ni-based superalloys continue to exert themselves as the industry standards in high stress and highly corrosive/oxidizing environments, such as are present in a gas turbine engine, due to their excellent high temperature strengths, thermal and microstructural stabilities, and oxidation and creep resistances. Gas turbine engines are essential components for energy generation and propulsion in the modern age. However, Ni-based superalloys are reaching their limits in the operating conditions of these engines due to their melting onset temperatures, which is approximately 1300 °C. Therefore, a new class of materials must be formulated to surpass the capabilities Ni-based superalloys, as increasing the operating temperature leads to increased efficiency and reductions in fuel consumption and greenhouse gas emissions. One of the proposed classes of materials is termed refractory complex concentrated alloys, or RCCAs, which consist of 4 or more refractory elements (in this study, selected from: Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, and W) in equimolar or near-equimolar proportions. So far, there have been highly promising results with these alloys, including far higher melting points than Ni-based superalloys and outstanding high-temperature strengths in non-oxidizing environments. However, improvements in room temperature ductility and high-temperature oxidation resistance are still needed for RCCAs. Also, given the millions of possible alloy compositions spanning various combinations and concentrations of refractory elements, more efficient methods than just serial experimental trials are needed for identifying RCCAs with desired properties. A coupled computational and experimental approach for exploring a wide range of alloy systems and compositions is crucial for accelerating the discovery of RCCAs that may be capable of replacing Ni-based superalloys. In this thesis, the CALPHAD method was utilized to generate basic thermodynamic properties of approximately 67,000 Al-bearing RCCAs. The alloys were then down-selected on the basis of certain criteria, including solidus temperature, volume percent BCC phase, and aluminum activity. Machine learning models with physics-based descriptors were used to select several BCC-based alloys for fabrication and characterization, and an active learning loop was employed to aid in rapid alloy discovery for high hardness and strength. This method resulted in rapid identification of 15 BCC-based, four component, Al-bearing RCCAs exhibiting room-temperature Vickers hardness from 1% to 35% above previously reported alloys. This work exemplifies the advantages of utilizing Integrated Computational Materials Engineering- and Materials Genome Initiative-driven approaches for the discovery and design of new materials with attractive properties.
Additional file 2 of HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review
Creators: name: Gotora, Piwai Terry
name: van der Sluis, Rencia
name: Williams, Monray Edward
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 2: Table S1. A Quality of assessment of studies conducted by PTG. B Quality of assessment of studies conducted by MEW.
THE IDENTIFICATION OF CRITICAL BARRIERS TO PLM IMPLEMENTATION
Creators: name: Re, Kevin J Del
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Other engineering not elsewhere classified

description: Product Lifecycle Management (PLM) is a well-known strategy used to improve business and manufacturing operations. Even with the attractive benefits it can provide, many companies struggle to successfully implement PLM solutions. This study proposes that this is due to a lack of knowledge on the critical barriers that affect the implementation of PLM solutions, and that reliance on the opinions of PLM professionals alone are not enough to create a successful implementation plan. This study addresses these issues with following research questions, what are the barriers to PLM implementation and is there a difference between those identified in literature and those confirmed by professionals, is there a difference between barrier impact rankings, based on professional opinion and those determined utilizing the DEMATEL method, and what are the critical barriers determined using the DEMATEL method supplemented by the MMDE algorithm? To answer these questions a series of two surveys were sent out to professionals in the PLM space with experience working on PLM implementation projects. The first of the two surveys was used to confirm the barriers that exist within the PLM implementation process. The second of the two surveys was used to gather information on the perceived impact of barriers and the causal relationships between barriers in the form of relationship matrices. To analyze these matrices the DEMATEL method supplemented by the MMDE algorithm was used. This study did not intend to provide absolute solutions to the critical barriers identified in this study, rather it intended to increase the success rate of PLM implementations by, confirming the barriers identified in the literature, providing information on the relationships between the barriers to PLM solution implementation and determine which of the barriers can be considered critical. Following these results of this study, the DEMATEL analysis method may supplement existing PLM implementation frameworks allowing companies to identify the critical barriers to implementation, allowing for better allocation of resources and ultimately a more successful PLM implementation.