cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Una nueva política social: la informalidad como norma y la formalidad como excepción
Creators: name: Simmons, Claire
name: Rodríguez-Morales, Andrés
name: Suárez, Dora
name: Pinzón Triana, Jhony Alexander
name: Suárez Suárez, Jesús David
name: Vásquez Franco, Clara Viviana
name: Sierra Gaona, Nohora Angélica
name: Garcia-Suaza, Andres
name: Londoño Aguirre, Diana
name: Yilmaz Vastardis, Anil
name: Tan, Celine
name: Van Ho, Tara
name: Alonso Bejarano, Carolina
name: Alessandrini, Donatella
name: Jaramillo Jassir, Ivan Daniel
name: Briceno-Ayala, Leonardo
name: Briceño, Natalia
name: Prieto-Rios, Enrique
name: Cortés Nieto, Johanna Del Pilar
name: Eslava, Luis
Publisher: name: Universidad del Rosario
Year: 2021

description: Este primer informe resalta la necesidad de una nueva política social partiendo del presupuesto que la informalidad es la norma y la formalidad la excepción en Colombia. La cifras de este informe provienen de la base de datos sobre la economía informal en Colombia elaborada por el equipo RUPTURAS21. Entre las fuentes de información se encuentran la Gran Encuesta Integrada de Hogares (GEIH), incluyendo la información de los departamentos de la Amazonía y Orinoquía y módulos adicionales relacionados con migración y población étnica, el Registro Especial de Prestadores de Servicios de Salud (REPS), información del Instituto Nacional Salud (INS), el Sistema Integrado de Información de la Protección Social (SISPRO), el Registro Único Nacional del Talento Humano en Salud (ReTHUS) y la Base de Datos Única de Afiliados (BDUA).
Characterizing Short-term Variability in VGOS Group Delay Observables
Creators: name: Albentosa-Ruiz, Ezequiel
name: Xu, Ming Hui
Publisher: name: Zenodo
Year: 2025

description: The VLBI Global Observing System (VGOS) uses ultra-wideband linear receivers (from 2 GHz to 14 GHz) for high-precision station geodetic positioning. To achieve accurate geodetic and astrometric measurements, VGOS observes each radio source in scans as short as 7 seconds. However, group delay observables are affected by instrumental effects and potential systematic errors introduced, for instance, by atmospheric turbulence. In this poster, we perform a time-series analysis of the VGOS group delay to characterize its short-term variability to investigate its stability.
Saberes globales y expertos locales en América Latina en el siglo XX
Creators: name: Allevi, José Ignacio (Ed.)
name: Rinke, Stefan (Ed.)
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Globalgeschichte
subject: Lateinamerika
subject: Wissensgeschichte
subject: Experten
subject: Staat
subject: Gesundheit
subject: Agrarwirtschaft
subject: Rockefeller Foundation
subject: Organisation Amerikanischer Staaten
subject: Kalter Krieg
subject: Organización de Estados Americanos
subject: 900 Geschichte und Geografie::980 Geschichte Südamerikas::980 Geschichte Südamerikas

description: In diesem Buch geht es zum einen um die Reichweite und die Grenzen, die der Global Turn als Interpretationsschlüssel bietet, sowie um seine Relevanz für die lateinamerikanische Forschungsagenda. Zum anderen geht es um die Geschichte der Zirkulation und Aneignung von Wissen auf dem Kontinent sowie der Rolle von Experten in den öffentlichen Debatten. Die Beiträge diskutieren neue Fragen für dieses Forschungsfeld, die die Handlungsfähigkeit der lokalen Akteure in den Vordergrund stellen. Sie zeigen die vielfältigen Möglichkeiten, mit denen diese Akteure die Agenden aus dem globalen Norden infrage stellten. Die Zusammenstellung ist entlang dreier Achsen gegliedert, die den Dialog zwischen spezifischem Fachwissen, lokalen und internationalen Akteuren und lateinamerikanischen Erfahrungen befragen, wobei der Schwerpunkt auf dem Gesundheitssektor, der Agrarfrage und den Prozessen liegt, die die westlichen Gesellschaften in der zweiten Nachkriegszeit neu definiert haben.
description: Este libro se inscribe en un doble debate historiográfico. Por un lado, los alcances y límites que el giro global ofrece como clave interpretativa, así como su pertinencia en la agenda de investigación latinoamericana en particular. Por otro, la discusión sobre la circulación del conocimiento en el continente, sus apropiaciones y el lugar que los expertos tuvieron para instalarlo en el debate público y estatal. Así, propone nuevos interrogantes para este programa en construcción, basados en rigurosas investigaciones empíricas que ubican en primer plano la capacidad de agenciamiento de los actores locales y las múltiples formas en que sus respuestas tensionaron los sentidos emanados desde las agendas del Norte global. La compilación se organiza en tres ejes que interrogan el diálogo entre experticias específicas, actores locales e internacionales y las experiencias latinoamericanas, con foco en las dinámicas sanitarias, la cuestión agraria y los procesos que redefinieron a las sociedades occidentales durante la segunda posguerra.
Postureo y pixeles para develar el presente: narrativas de los parques arqueológicos en la red
Creators: name: Cruz-González, María Catalina
name: Salge, Manuel
Publisher: name: Universidad Externado de Colombia. Facultad de Comunicación Social-Periodismo.
Year: 2024
Subjects: subject: Ambiente electrónico - Diseño
subject: Ambiente electrónico - Especificaciones
subject: Redes sociales - Estrategia y técnicas
subject: Comunicaciones digitales - Aspectos sociales
subject: Formatos digitales - Aspectos sociales
subject: Arqueología - Innovaciones tecnológicas
subject: Parques naturales - Sistemas de comunicación - Colombia
subject: Parques nacionales - Innovaciones tecnológicas - Colombia
subject: Comunicación
subject: Estudios críticos del patrimonio
subject: Parques Arqueológicos
subject: Redes Sociales

description: Postureo y píxeles para develar el presente: narrativas de los parques arqueológicos en la red relaciona los parques arqueológicos en Colombia y el mundo digital, explorando las publicaciones gene- radas, consumidas y compartidas en redes socia- les. Este estudio desafía nuestra comprensión convencional al cuestionar la relación entre la realidad física y sus representaciones virtuales, entre las narrativas oficiales y las reinterpretaciones individuales. A través de esta investigación, se abre un diálogo sobre el papel de la comunicación y el patrimonio cultural en la sociedad contemporánea, invitándonos a reflexionar sobre el futuro de estos campos en un mundo influenciado por la tecnología y las narrativas digitales.
description: Posturing and Pixels to Unveil the Present: Narratives of Archaeological Parks in the Network relates archaeological parks in Colombia and the digital world, exploring the publications generated, consumed, and shared on social networks. This study challenges our conventional understanding by questioning the relationship between physical reality and its virtual representations, between official narratives and individual reinterpretations. Through this research, a dialogue is opened about the role of communication and cultural heritage in contemporary society, inviting us to reflect on the future of these fields in a world influenced by technology and digital narratives.
Pedagogía y didáctica Esp
Creators: name: Rojas Valbuena, Liliana
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Profundizar en el análisis de los métodos en un curso de enseñanza del español como lengua extranjera y segunda lengua, con el propósito de enriquecer y perfeccionar las estrategias pedagógicas para el aprendizaje de este idioma. Objetivos específicos: * Identificar las principales características de los métodos de enseñanza usados para enseñar/aprender las lenguas extranjeras desde el Siglo XVIII hasta hoy. * Definir todos los participantes en el proceso de aprendizaje de una lengua extranjera. * Reflexionar sobre el valor del enfoque comunicativo, el enfoque nocional funcional y el enfoque por tareas, y considerarlos como metodologías para enseñar la lengua extranjera.
description: El curso explorará los métodos y las dinámicas de enseñanza de un nuevo lenguaje, basándose en la pedagogía antigua hasta la actualidad. Además, se reflexionará sobre el enfoque comunicativo, el enfoque nocional funcional y el enfoque por tareas como metodologías efectivas en la enseñanza del español como lengua extranjera; por otro lado, los participantes podrán enriquecer y perfeccionar las estrategias pedagógicas para el aprendizaje de este idioma, considerando que la persona que vaya a aprender el idioma está entrando en un nuevo terreno y estas estrategias le ayudará a los participantes hacerse cargo de situaciones que impliquen alguna dificultad de aprendizaje en el idioma.
Aspectos básicos de la protección de datos personales
Creators: name: Camacho Andrade, Javier
name: Ruiz Mora, Andrea Jhoanna
name: Triana Cano, Jorge Eliecer
name: Torres Pachón, Olmo
name: Useche, Margarita Maria
name: Vallejo Díaz, Diego Mauricio
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Proporcionar los conocimientos necesarios para entender y aplicar efectivamente las políticas y las prácticas de protección de los datos. Objetivos Específicos: * Describir los aspectos más relevantes de la protección de los datos personales. * Explicar aquellos elementos que permiten diferenciar las categorías, el ciclo y los usos de los datos personales. * Analizar desde el quehacer institucional el rol que cada uno desempeña respecto al tratamiento y la administración de los datos personales.
description: Este programa fue diseñado con el propósito de brindar una comprensión integral sobre la protección de datos personales. Esta información es importante en el desarrollo personal y profesional, siendo fundamental para el cumplimiento institucional de las normativas sobre el manejo responsable de la información personal. De manera que los participantes conocerán las herramientas necesarias para entender y aplicar eficazmente las políticas de protección de datos, asegurando la confidencialidad y la seguridad de la información. Este curso enseñará a enfrentar los desafíos actuales en materia de privacidad y seguridad de datos con confianza y responsabilidad.
Circuito de competencias Banner - Administrativos
Creators: name: Lengua González, Gloria Julieth
name: Parra, Carlos Julio
name: Pineda Rodríguez, Laura Katherine
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Ganar la competencia de ciclismo, asegurando obtener las medallas que certificarán el conocimiento del sistema banner. Objetivos Específicos: * Entender el funcionamiento y la lógica a aplicar en el sistema banner. * Gestionar los procesos académicos y administrativos en el sistema de información banner en pro del estudiante.
description: Este espacio es una competencia de ciclismo en donde se realizará un recorrido por los hitos más importantes de este sistema, el circuito se compone de varias etapas, en las que cada una de ellas cuenta con un contenido en específico como la creación de NRC clase y dummy, la inscripción bloque primer ingreso, inscripción de NRC, y autoservicio web del estudiante. A medida que el participante vaya terminando las estepas comenzará a obtener medallas que lo ayudarán a convertirse en campeón.
Kinetic Studies Of The Thermolysis Of 3-Halogenated-4,5-Dihydro-3h-Pyrazoles
Creators: name: Desalegn, Nebiyou
Publisher: name: Georgia State University
Year: 2005

description: 3-Chloro-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3b) and 3-bromo-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3c) were prepared for the thermolysis project. The thermal decompositions of 3b and 3c were monitored using 1H NMR spectroscopy. Plots of ln (% starting material) vs. time (sec) were linear for at least two half lives and the first order rate constants were determined over at least a 30o temperature range. The relative reactivity was found to be 3c > 3b. The activation parameters determined for the thermal decomposition of the pyrazoline at 150oC were found to be: for 3b &#;H? = 33 &#;1.0 kcal/mol, &#;S? = -2.4 &#; 0.07eu , k150 0 = 7.34 &#; 0.44 x 10 -5 s-1 ; for 3c &#;H? = 30&#;0.2 kcal/mol, &#;S? = -6.9 &#;0.03 eu, k150o = 42.3&#;0.7 x 10-5 s-1. Thermal decomposition of 3b both neat and in dibromobenzene (DBB) resulted in the formation of an intermediate 2,3-diphenyl-4-methyl-1,3-pentadiene (8) as a major product and minor isomers of 8. These intermediates then thermally decomposed to 1,1,3-trimethyl-2-phenyl-1H-indene (9) via an acid catalyzed process. In order to gain a mechanistic understanding (ionic vs. radical pathways) of the thermal decomposition of 3b, a product study was conducted in protic solvents. In methanol and ethanol, 3b underwent an ionic reaction (SN1-type) with the solvent to produce 3-methoxy/ethoxy-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3/3d) in good yield. The reaction of 3b with refluxing protic solvents led to the development of new method for the synthesis of alkoxy-4,5-dihydro-3H-pyrazoles which is both safe and efficient.
Ofimática básica
Creators: name: (:Unkn) Unknown
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Dominar de manera integral y aplicar con destreza las herramientas fundamentales de la ofimática, incluyendo Word, PowerPoint y Excel, para maximizar la eficiencia y la productividad en entornos laborales y académicos. Objetivos Específicos: * Dominar el uso de Microsoft Word, desde la creación básica de documentos hasta el manejo avanzado de funciones como formato, estilos, tablas y colaboración en documentos compartidos. * Aprender a utilizar Microsoft PowerPoint de manera efectiva, abarcando desde la creación básica de presentaciones hasta las técnicas avanzadas de diseño y animación. * Aplicar el uso de Microsoft Excel, desde la introducción a las funciones básicas aplicando fórmulas, tablas dinámicas y gráficos.
description: El curso se centrará en un acercamiento completo a las herramientas esenciales de la ofimática, tales como Word, PowerPoint y Excel. Esta experiencia se encuentra especialmente diseñada para abarcar desde los fundamentos más básicos hasta las técnicas avanzadas en el manejo de estas aplicaciones. Por lo tanto, resulta ideal para aquellos participantes que se hallan en una etapa inicial de su aprendizaje en estas plataformas y no poseen conocimientos previos al respecto
Hexa-aryl/alkylsubstituted Cyclopropanes
Creators: name: Truong, Phong
Publisher: name: Georgia State University
Year: 2006

description: A series of penta-aryl/alkyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole 5a-c was synthesized by addition of methyllithium or phenylllithium followed by trapping the nitrogen anion intermediate with tosyl-fluoride to cyclic azines 2a,b.  Addition of methyllithium or phenyllithium to 5a-c generated a series of hexa-aryl/alkylsubstituted-4,5-dihydro-3H-pyrazoles 6a-c.  Neat thermolysis of hexa-aryl/alkylsubstituted-4,5-dihydro-3H-pyrazoles 6a-c at 200◦C produced hexa-aryl/alkylsubstituted cyclopropanes 7a-c in high yield.
Historia crítica-epistemológica de la medicina occidental
Creators: name: Arroyave Bernal, Carlos Aandrés
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Explorar y comprender en profundidad las diversas corrientes de pensamiento en el ámbito de la salud, destacando su contexto cultural y los elementos que las integran. Objetivos Específicos: Resultados de aprendizaje * Describir y analizar la historicidad de las relaciones entre las medicinas y los cuerpos. * Analizar y discutir los hitos en ciencia y medicina, y su influencia en el conocimiento y la práctica médica contemporánea, específicamente en lo referente al “nacimiento de la clínica”, la medicina de laboratorio, la revolución terapéutica y la medicina física. * Examinar los casos emblemáticos como el de la asepsia, la década del cerebro, el trasplante de órganos y el genoma humano, que han generado transformaciones en la vida social y en las mentalidades contemporáneas.
description: El curso pretende analizar y debatir como punto de partida las relaciones entre medicinas y cuerpos. Se describirán y analizarán grandes hitos en el ensamblaje entre la ciencia y la medicina, donde se plantea su vínculo como un logro cultural, dado su histórica separación y tensiones alrededor de procesos como el de la “medicalización” del cuerpo. Además, se analizará la consolidación de la medicina física, la cual expresa la aplicación de las tecnologías en la medicina como la radiación o los rayos x para curar y diagnosticar las enfermedades. Posteriormente, continuaremos rastreando los casos emblemáticos como el de la asepsia, la década del cerebro, el trasplante de órganos, y el genoma humano.
Regulación de mercados
Creators: name: Toro Ochoa, David
name: Aguilar Abaunza, Daniela
name: Caicedo Simijaca, Danna Vanessa
name: Ortiz Baquero, Ingrid Soraya
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales : Dominar el concepto y las derivaciones de información sobre las normas de protección a la competencia, asegurando una comprensión integral y la capacidad de aplicar eficazmente esta información en diversos contextos. Objetivos Específicos: * Entender las normas de protección a la competencia como aquellas que buscan el funcionamiento correcto del mercado, y en definitiva, el bienestar de los consumidores. * Adentrarse en el derecho de la competencia en Estados Unidos para que puedan entender el origen de nuestras normas de protección a la competencia y relacionarlas entre sí. * Conocer las particularidades de las normas de protección de la competencia para los servicios públicos domiciliarios, y en especial, para el servicio de energía eléctrica.
description: En este curso se abordará de manera transversal las normas de protección a la competencia que resultan aplicables a todos los sectores de la economía y particularmente al sector energético. Se desarrollarán normas constitucionales y legales que componen el régimen general de protección a la competencia. Se iniciará con los fundamentos constitucionales de la libre competencia económica. Posteriormente, revisaremos cuáles son los ámbitos de aplicación de las normas y sus objetivos, además de las funciones de la autoridad de competencia se desarrollará el régimen de concentraciones empresariales y las prácticas antimonopólicas.
La construcción de conocimiento en los campos de la salud y la enfermedad I
Creators: name: Guevara Morales, Luisa Juiana
name: Zapata García, José Gabrie
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Adquirir los marcos reflexivos y metodológicos necesarios en su campo temático desarrollando una primera versión del proyecto de investigación durante el curso. Objetivos Específicos: Resultados de aprendizaje * Elaborar estados de conocimiento y proyectos de investigación que les permita identificar problemas complejos en torno a la salud - enfermedad. * Generar un diálogo constructivo con la realidad y los saberes de otras disciplinas o formaciones que configuran la creación de un ambiente y una dinámica transdisciplinaria que les permita plantear problemas de investigación sobre procesos de la salud y la enfermedad. * Conocer la producción investigativa en campos de frontera entre las ciencias sociales y las ciencias de la vida para analizar críticamente los diferentes insumos de las problemáticas de la salud - enfermedad.
description: Los estudiantes de este curso participarán en un diálogo creado entre distintas disciplinas y diversas profesiones alrededor de los procesos de la salud y la enfermedad, en cuyo campo temático podrán desarrollar sus metas de aprendizaje. Se profundizará en la búsqueda de la sistematización de la escritura, la producción académica, y la escritura de artículos en documentos de estado del arte. Además, se elaborará el planteamiento de un problema que debe ser sustentado en datos, autores e investigaciones, se planteará un campo de investigación inicial y se expondrán los desarrollos teóricos, conceptuales, metodológicos y sociales sobre el problema que se va a investigar.
Preparación de propuestas, monitoreo y evaluación Diplo PIP
Creators: name: Prieto Cardozo, Jorge Enrique
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos Generales: * Lograr establecer coherencia y continuidad en el desarrollo de un proyecto de manera efectiva y consistente a lo largo del curso. Objetivos Específicos: * Determinar por medio de la matriz de marco lógico, como elemento central de un proyecto de desarrollo, en general o de cooperación internacional, en particular, la estrategia, el enfoque y el alcance de la intervención. * Construir el componente narrativo de la propuesta sobre visibilizar los elementos fundamentales del contexto y del análisis del problema y de sus causas, garantizando la comprensión con la matriz de marco lógico. * Determinar la forma como se recolectará y analizará la información para establecer el progreso, los resultados e impactos de la ejecución del proyecto.
description: Este espacio brinda herramientas prácticas para la preparación de propuestas, monitoreo y evaluación de proyectos. Se profundizará en los fundamentos de la fase de ejecución y en los elementos del componente narrativo. Además, se conocerá sobre la construcción del presupuesto de una propuesta de cooperación por medio de la ejecución, presupuesto y un plan operativo. Se revisarán los asuntos financieros y las necesidades de recursos que respaldarán la ejecución, que además hacen parte de los criterios para determinar la viabilidad de la propuesta presentada. Se entenderá los contenidos de la matriz de marco lógico y el presupuesto.
Tecnología y regulación
Creators: name: Piñeros Ramírez, Cesar Augusto
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos generales: * Comprender la tecnología en el sector energético, abordando aspectos técnicos, económicos, sociales y regulatorios. Objetivos específicos: * Comprender el impacto de la digitalización en el sector energético, analizando las oportunidades y loa riesgos de las nuevas tecnologías. * Identificar los aspectos más importantes de las tecnologías de la digitalización y los elementos de las convergencias entre el sector energético y otros sectores. * Conocer cómo las tecnologías digitales reestructuran los mercados, los procesos actuales y crean nuevos esquemas económicos.
description: Este curso proporciona a los participantes un amplio entendimiento de la tecnología en el sector energético. Se abordarán diversos aspectos técnicos, económicos, sociales y regulatorios, con el fin de ofrecer un análisis exhaustivo que permita apreciar tanto el potencial disruptivo de la tecnología como los riesgos asociados a la transformación digital. A través de un enfoque multidisciplinario se explorarán las implicaciones de la innovación tecnológica en la industria energética, fomentando una reflexión crítica sobre su impacto en la sociedad, la economía y el medioambiente.
Regulación de tarifas
Creators: name: Graciano, Óscar Andrés
Publisher: name: Universidad Externado de Colombia
Year: 2022

description: Objetivos generales: * Entender los principios básicos de la regulación de mercados para aplicarlos de manera efectiva en las situaciones prácticas. Objetivos específicos: * Comprender los diferentes esquemas regulatorios que existen para remunerar las actividades que constituyen un servicio público. * Reconocer y diferenciar la composición de los esquemas regulatorios existentes. * Identificar en qué momento se debe aplicar uno u otro esquema regulatorio y cómo aplicarlos adecuadamente
description: A través del curso se pretende facilitar al estudiante los conocimientos regulatorios que permitan de manera detallada conocer los aspectos fundamentales relacionados con la regulación de mercados. Este programa se enfoca en dotar a los participantes de herramientas necesarias, de tal manera que los estudiantes tengan la capacidad de realizar el cálculo completo de las tarifas y puedan tomar las decisiones por medio de los resultados. Además, se brindará una comprensión exhaustiva del procedimiento para el cálculo de las tarifas, incluyendo el análisis de las metodologías pertinentes y su aplicación práctica.
Supplementary document for A PVA-SM microstructure enhanced ratiometric fluorescence probe for formaldehyde detection in solution and gas - 5511084.pdf
Creators: name: Wang, Tianci
name: Wang, Haiyan
name: Xia, Pengfei
name: Xue, Sheng
name: Yang, Guanjie
name: Li, Heng
name: Li, Zongbao
name: Jiang, Xiaofang
name: Xing, Xiaobo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Experimental details and supporting figures and tables
Inactivation of Choline Oxidase by Irreversible Inhibitors or Storage Conditions
Creators: name: Hoang, Jane
Publisher: name: Georgia State University
Year: 2006

description: Choline oxidase from Arthrobacter globiformis is a flavin-dependent enzyme that catalyzes the oxidation of choline to betaine aldehyde through two sequential hydride-transfer steps.  The study of this enzyme is of importance to the understanding of glycine betaine biosynthesis found in pathogenic bacterial or economic relevant crop plants as a response to temperature and salt stress in adverse environment.  In this study, chemical modification of choline oxidase using two irreversible inhibitors, tetranitromethane and phenylhydrazine, was performed in order to gain insights into the active site structure of the enzyme.  Choline oxidase can also be inactivated irreversibly by freezing in 20 mM sodium phosphate and 20 mM sodium pyrophosphate at pH 6 and -20 oC.  The results showed that enzyme inactivation was due to a localized conformational change associated with the ionization of a group in close proximity to the flavin cofactor and led to a complete lost of catalytic activity.
Impacts of COVID-19 on trans and non-binary people in Canada: a qualitative analysis of responses to a national survey
Creators: name: Kia, Hannah
name: Rutherford, Leo
name: Jackson, Randy
name: Grigorovich, Alisa
name: Ricote, Carol L.
name: Scheim, Ayden I.
name: Bauer, Greta R.
Publisher: name: BioMed Central
Year: 2023

description: Background Emerging international evidence indicates the COVID-19 pandemic has exacerbated socioeconomic and health challenges faced by transgender (trans) and non-binary populations globally. This qualitative study is among the first to characterize impacts of the pandemic on these groups in Canada. Methods Drawing on data from the Trans PULSE Canada survey (N = 820), we used thematic analysis to examine the free-form responses of 697 participants to one open-ended question on impacts of the pandemic. We first organized responses into descriptive themes, and then used this preliminary analytical process to construct more refined, higher order themes that provided a rich account of the pandemic’s impacts. Results Our results are organized into five themes that highlight the pandemic’s impacts on trans and non-binary populations in Canada. These include: (1) reduced access to both gender-affirming and other healthcare, (2) heightened financial, employment, and housing precarity, (3) strained social networks in an era of physical distancing and virtual communication, (4) an intensification of safety concerns, and (5) changes in experiences of gender affirmation. Conclusion Our findings highlight the pandemic’s systemic impacts on the lives of trans and non-binary people in domains such as healthcare, employment, and housing, and on the social networks of these groups, many of which reflect an exacerbation of pre-existing inequities. Based on our analysis, we recommend that public health researchers, policymakers, and practitioners attend to the structural impacts of the pandemic on these groups as primary sites of inquiry and intervention.
The Application of Weak-Anion Exchange Chromatography for the Analysis of Organic Zwitterions Using LC/MS/MS
Creators: name: Bishop, Michael
Publisher: name: Georgia State University
Year: 2006

description: A rapid and accurate quantitative method was developed and validated for the analysis of four urinary organic acids with nitrogen containing functional groups, formiminoglutamic acid (FIGLU), pyroglutamic acid (PYRGLU), 5-hydroxyindoleacetic acid (5-HIAA), and 2-methylhippuric acid (2-METHIP) by liquid chromatography tandem mass spectrometry (LC/MS/MS). The chromatography was developed using a weak anion-exchange amino column that provided mixed-mode retention of the analytes. The elution gradient relied on changes in mobile phase pH over a concave gradient, without the use of counter-ions or concentrated salt buffers. A simple sample preparation was used, only requiring the dilution of urine prior to instrumental analysis. The method was validated based on linearity (r2 ?? 0.995), accuracy (85?C115%), precision (C.V. < 12%), sample preparation stability (?? 5%, 72h), and established patient ranges. The method was found to be both efficient and accurate for the analysis of urinary zwitterionic organic acids.
DNA Photocleavage by Acridine and Phenazine-Based Chromophores
Creators: name: Fields, Earl
Publisher: name: Georgia State University
Year: 2006

description: Photodynamic therapy (PDT) is a promising approach used in the treatment of cancer, age related macular degeneration, psoriasis, and other diseases. Our research is focused on the discovery of new photonucleases for use in PDT. This study evaluates the photo-induced DNA cleaving abilities of a series of acridine and phenazine-based chromophores. The extended, aromatic ring systems of these compounds are expected to intercalate between adjoining base pairs in the DNA double-helix. Once irradiated, strand breakage, or nicking of plasmid DNA is achieved at micromolar concentrations of compound (pH 7.0 and 22 ?C). Our scavenger experiments show that this process occurs as a result of direct electron transfer to oxygen and/or by means of energy transfer which results in the production of singlet oxygen. Three of the photonucleases being examined were designed to chelate metal. These exhibited increased levels of DNA photocleavage in the presence of copper(II).
The Hydrolysis of Naphthalene Diimides
Creators: name: Kim, Michelle
Publisher: name: Georgia State University
Year: 2007

description: The hydrolyses of naphthalene diimides (NDIs) bearing aliphatic side chains with N-methylpyrrolidinium groups placed two (1) and three (5) atoms from the central core were studied. The Ka values for the first and second hydrolyses for 1 were 2.5 ¤ 0.2 x 105 M-1 and 2.0 ¤ 0.1 x 102 M-1, respectively; for 5 they were 1.4 ¤ 0.1 x 105 M-1 and 44 ¤ 2 M-1, respectively. NDI 1 hydrolyzed 6.8 times faster than did 5. The rates for the first and second hydrolyses of 1 at 100 mM hydroxide measured by stopped-flow were 17.0 ¤ 0.2 s-1 and 53.0 ¤ 0.1 x 10-2 s-1, respectively. NMR showed both the syn and anti isomers of the diamide species. Syntheses of other derivatives are reported. Overall, this study shows that the rate of hydrolysis of NDIs is increased when the cationic charge is moved closer to the NDI core.
Biochemical Characterization of 2-Nitropropane Dioxygenase from Hansenula MRAKII
Creators: name: Mijatovic, Slavica
Publisher: name: Georgia State University
Year: 2008

description: 2-Nitropropane dioxygenase from Hansenula mrakii is a flavin-dependent enzyme that catalyzes the oxidation of anionic nitroalkanes into the corresponding carbonyl compounds and nitrite, with oxygen as the electron acceptor. Although nitroalkanes are anticipated to be toxic and carcinogenic, they are used widely in chemical industry for a quick and effective way of synthesizing common reagents. Consequently, the biochemical and biophysical analysis of 2-nitropropane dioxyganase has a potential for bioremediation purposes. In this study, recombinant enzyme is purified to high levels, allowing for detailed characterization. The biochemical analysis of 2-nitropropane dioxygenase presented in this study has established that enzyme utilizes alkyl nitronates as substrates by forming an anionic flavosemiquinone in catalysis. The enzyme is inhibited by halide ions, does not contain iron and has a positive charge located close to the N(1)-C(2)=O locus of the isoalloxazine moiety of the FMN cofactor.
Spacious Grammar : Agency and Intention in the Teaching of Research Writing
Creators: name: Thieme, Katja
Publisher: name: The University of British Columbia
Year: 2024

description: Standardized academic English is now understood to be rooted in histories and practices that are colonial, classist, nationalist, heteronormative, ableist, and sexist. Current teaching of academic English carries an ethos of making practices of research writing accessible to students from marginalized backgrounds through explicit attention to language patterns and genre structures. In the context of both ideological critique and explicit pedagogy, I discuss three pragmatic elements of research writing—positionality, citation, and evaluation—with examples from one of my courses. I present these elements and my approach to teaching them as a practice that is attentive to both details of published scholarship and students’ agency and intentionality in shaping their own writing projects, claims, and arguments. My work is framed by a functional approach to grammar where grammar is not interesting as a standardized apparatus but as a code that provides a range of options for producing performative effects. I call this spacious grammar.
The Analysis of Antimicrobial Testing Vincetoxicum stocksii and Isolation of a Highly Active Compound Against Candida albicans by Using Various Different Techniques.
Creators: name: Momin, Vasim
Publisher: name: Georgia State University
Year: 2008

description: The purpose is to isolate a natural compound, which shows a high activity against Candida albicans, from plant,  Vincetoxicum stocksii.  Bio-Assay, Thin layer Chromatography, Column Chromatography, TLC bio Assay, and other extraction techniques are used in order to isolate the active compound.  First, bio assay technique is carried out on the crude gum.  Next, several flash chromatography columns are carried out in order to isolate the target compound, which has a Rf value of ~0.53 in 10:1 DCM/methanol solvent mixture.  The TLC bioassay technique is also carried out in order to confirm the hypothesis that the target compound is indeed active.
One Workshop to Rule Them All: Forging RDM skills among PhD Candidates in the Life Sciences
Creators: name: Kate, Emily
name: Feichtinger, Michael
Publisher: name: Zenodo
Year: 2025
Subjects: Research Data Management
Open Science

description: In June 2023, the Data Stewards at the Faculty of Life Sciences and the Centre for Microbiology and Environmental Systems Science at the University of Vienna launched a new workshop aimed at introducing Ph.D. candidates and Masters students in the life sciences to the fundamentals of research data management (RDM). This course, titled 'Research Data Management for Ph.D. Candidates in the Life Sciences,' utilizes a blended learning approach that combines instructional content with various activities to help students practice their skills. Participants complete an online module (approximately 6 hours) before attending two in-person half-day seminars. The online module focuses on information transfer, while the seminars emphasize interactive activities, discussions, and Q&A sessions.

This poster provides a brief overview of the workshop program, along with tips and tricks learned by the Data Stewards. Data from pre- and post-learning assessments are also presented, demonstrating changes in student knowledge levels and comfort with RDM topics. We also discuss our future plans, which include collaboration with UNIVIE doctoral schools, the launch of an Open Science Community, and the adaptation of the course content for students in the Humanities.
Synthesis of 2,4-Disubstituted Pyrimidines of Possible Biological Interest
Creators: name: Barnes, Samuel
Publisher: name: Georgia State University
Year: 2008

description: The synthesis of 2,4-disubstituted pyrimidine derivatives is described. The synthetic route involved the addition reaction of lithiated intermediates, mostly heterocycles, to position 4 of 2-chloropyrimidine to give a dihydropyrimidine intermediate which was oxidized back to a pyrimidine. This was followed by nucleophilic aromatic substitution with various amines of the chlorine in the position 2. A number of compounds were prepared which showed binding towards various serotonin receptors in preliminary biological evaluation.
Synthesis of 2,4-Disubstituted Pyrimidine Derivatives as Potential  5-HT7 Receptor Antagonist.
Creators: name: Sullivan, Shannon
Publisher: name: Georgia State University
Year: 2008

description: The synthesis of a series of 2-chloropyrimidine derivatives is described. The synthesis began with a nucleophilic addition of lithiated heterocyclic molecules to the 4 position of 2-chloropyrimidine to give dihydropyrimidine intermediates.  The intermediates were oxidized to the pyrimidine ring using the DDQ method. This was followed by an addition-elimination reaction of an amine to the 2-chloropyrimidine derivative. The structure and properties of the final compounds were analyzed by melting point, combustion analysis, and 13C-NMR and 1H-NMR spectroscopy. Biological activities in vitro of the synthesized compounds as antagonists of the 5-HT2a and 5-HT7 receptors were determined by an independent laboratory.
Cyclic Enzymatic Solid Phase Synthesis of DNA Oligonucleotides on an Epoxide-Activated Resin
Creators: name: Khan, Ahmed
Publisher: name: Georgia State University
Year: 2008

description: Standard chemical DNA synthesis with isotope labels requires expensive reagents; moreover, a large excess of phosphoramadites (typically 50-100 fold) must be used. We developed a process where enzymatic cyclic solid phase synthesis of DNA allows for more economic reagent use. A DNA template was immobilized on an epoxy-activated solid support. This chemistry was chosen because the formed linkage is inert to high pH conditions.  High efficiency of the covalent attachment was observed when the reaction was carried out in MgCl2/CAPS buffer. It was found that Mg2+ enables the reaction to be completed over a period of 14 h, compared to 72 h under standard conditions. DNA synthesis was carried in a cyclic fashion on a support bound DNA using Klenow fragment.
Investigating Kisspeptin-signalling in sexual and emotional brain processing in men
Creators: name: Mills, Edouard Gregory Andrew
Publisher: name: Imperial College London
Year: 2022

description: The reproductive neuropeptide kisspeptin acts as the master regulator of the hypothalamic-pituitary-gonadal axis, where it has important roles in controlling downstream reproductive hormone secretion. Beyond the hypothalamus, kisspeptin and its cognate receptor are expressed throughout the rodent and human limbic systems, which are areas implicated in the control of socio-reproductive behaviours. Consistent with this, emerging data reveals that kisspeptin has important neuromodulatory functions in reproductive behaviour. However, data in this area remains limited to predominantly animal models. Using a combination of physiological, behavioural, hormonal and functional neuroimaging, this thesis investigates kisspeptin’s effects on three unexplored areas in human reproductive neuroendocrinology: 1) brain responses to olfactory and visual cues of attraction in healthy men; 2) brain responses to sexual stimuli in men with Hypoactive Sexual Desire Disorder (HSDD); 3) reproductive hormone secretion following intranasal delivery. The results broaden our understanding of kisspeptin’s physiological roles in humans beyond the classical reproductive axis by supporting and extending the animal data implicating kisspeptin in the control of reproductive behaviour. Moving from healthy men into a patient group, my findings reveal kisspeptin as the first effective treatment option for men with HSDD. From a clinical development perspective, the identification that intranasal kisspeptin delivery stimulates reproductive hormone secretion, highlights kisspeptin as a feasible and realistic treatment strategy for patients with reproductive and related psychosexual disorders. To this end, these data provide key mechanistic and pharmacological insight for the neurophysiological actions of kisspeptin and unlock kisspeptin as a therapeutic target for the management of reproductive and related psychosexual disorders.
The Fate and Transport of Chemical Warfare Agent Simulants in Complex Matrices
Creators: name: Daphney, Cedrick
Publisher: name: Georgia State University
Year: 2008

description: Experiments to determine the fate and transport of the chemical warfare agent (CWA) simulants diisopropyl fluorophosphate (DIFP), O,S-diethyl methylphosphonothioate (OSDEMP), and 2-Chloroethyl ethyl sulfide (CEES)  exposed to complex matrix systems are reported here.  The aforementioned simulants were used in place of O-isopropyl methylphosphonofluoridate (GB), O-Ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX), and Bis (2-chloroethyl) sulfide (HD), respectively.  At ambient temperature, simulant pH (2.63 to 12.01) and reaction time (1 minute to 24 hours) were found to have significant influence on the recovery of simulants from charcoal, plastic, and TAP (butyl rubber gloves) in aqueous media.  Buffer systems used included, phosphate, acetate, borate, and disodium tetraborate.  Organic extractions were carried out using a 90:10 (v/v) dichloromethane / 2-propanol solution.  All extracts were analyzed with a gas chromatograph equipped with flame ionization and flame photometric detectors (GC-FID-FPD).  The FPD was used to determine the amount of simulant recovery.
Development of a cloud FEA platform for advanced FE simulations of metal forming processes
Creators: name: Dhawan, Saksham
Publisher: name: Imperial College London
Year: 2022

description: The overall aim of this PhD research project is to develop a world leading, European-centred open innovation repository for knowledge transfer and data sharing across different manufacturing sectors based on a patented, lab proven cloud FEA simulation system SmartForming. This patented platform has been developed, lab-proven and is currently hosting 200+ scientific plug-ins for metal forming applications. The interoperability of the platform will enable the seamless integration of various research fields and manufacturing sectors through ready-to-use open-source scientific ‘plug-ins’. New ‘plug-ins’ have been developed with the leaders in material characterisation and physics-based modelling and the industry to create a seamless and standardised platform with direct connection to key metal forming processes, e.g., hot aluminium stamping. The developed open framework will disrupt the European manufacturing industry through enhancing the efficiency by 80-90% in terms of time reductions for material and product development processes. The innovative cloud framework will find widespread application by metal forming industry for disrupting markets and creating high economic and strategic impact.
Analyses and Applications of Metalloprotein Complexes
Creators: name: Kirberger, Michael
Publisher: name: Georgia State University
Year: 2008

description: The structural characteristics associated with the binding of beneficial metals (i.e. - Mg2+, Zn2+ and Ca2+) to natural proteins has typically received more attention than competitive binding by toxic metals (e.g. ? Pb2+, Hg2+, Cd2+, La3+, etc.). In this thesis, a statistical analysis of Pb2+-binding in crystallized protein structures indicates that Pb2+ does not bind preferentially with nitrogen, as generally assumed, but binds predominantly with oxygen, and to a lesser degree, sulfur. A comparison of Ca2+ and Pb2+ indicates that Pb2+ binds with a wider range of coordination numbers, with less formal change, and with less defined structure than Ca2+. The Pb2+ ion also appears to displace Ca2+ with little conformational stress in calcium binding proteins (CaBP?s). Experimental data from the binding of metals with engineered fluorescent proteins indicate that both Pb2+ and Gd3+ will occupy grafted calcium-binding sites with greater affinity than Ca2+, and strong evidence is presented to support the hypothesis that Pb2+ and Gd3+ will bind non-specifically on the protein surface. These results suggest that toxicity is associated with two binding mechanisms: displacement of the metal cofactor which disrupts protein function, and non-specific binding which maintains higher solubility of the metal.
Electrochemical Studies of Substituted Anthraquinones
Creators: name: Rabinowitz, Daniel
Publisher: name: Georgia State University
Year: 2008

description: Electrochemical potentials of a series of anthraquinone derivatives were studied in both aqueous solution and acetonitrile.  The long term goal of this work was to find derivatives which could be reduced easily for studies of photoinduced electron transfer in DNA.  Our immediate goal was to find the substitution group that gave the least negative redox potential value.  Of all derivatives studied, the anthraquinone imides as a class had the least negative redox potentials, in the range of -0.600 to -0.550 V vs. SCE.  One of the anthraquinones studied, one derivative (deoxyadenosine conjugated with an ethynyl linker to an anthraquinone with two ester substituents) was also in this range.  A study of a series of anthraquinones conjugated with ethynyl and ethanyl linkers showed that the ethynyl linker was more effective than the ethanyl linker in lowering the redox potential of anthraquinone.
Climate Change Effects on Heat Waves and Future Heat Wave-Associated IHD Mortality in Germany
Creators: name: Zacharias, Stefan
name: Mücke, Hans-Guido
name: Koppe, Christina
Publisher: name: My University
Year: 2015
Subjects: Menschliche Gesundheit
Sterblichkeit
Klimaänderung
Bundesrepublik Deutschland

description: The influence of future climate change on the occurrence of heat waves and its implications for heat wave-related mortality due to ischemic heart diseases (IHD) in Germany is studied. Simulations of 19 regional climate models with a spatial resolution of 0.25˚ Ž 0.25˚ forced by the moderate climate change scenario A1B are analyzed. Three model time periods of 30 years are evaluated, representing present climate (1971-2000), near future climate (2021-2050), and remote future climate (2069-2098). Heat waves are defined as periods of at least three consecutive days with daily mean air temperature above the 97.5th percentile of the all-season temperature distribution. Based on the model simulations, future heat waves in Germany will be significantly more frequent, longer lasting and more intense. By the end of the 21st century, the number of heat waves will be tripled compared to present climate. Additionally, the average duration of heat waves will increase by 25%, accompanied by an increase of the average temperature during heat waves by about 1 K. Regional analyses show that stronger than average climate change effects are observed particularly in the southern regions of Germany. Furthermore, we investigated climate change impacts on IHD mortality in Germany applying temperature projections from 19 regional climate models to heat wave mortality relationships identified in a previous study. Future IHD excess deaths were calculated both in the absence and presence of some acclimatization (i.e., that people are able to physiologically acclimatize to enhanced temperature levels in the future time periods by 0% and 50%, respectively). In addition to changes in heat wave frequency, we incorporated also changes in heat wave intensity and duration into the future mortality evaluations. The results indicate that by the end of the 21st century the annual number of IHD excess deaths in Germany attributable to heat waves is expected to rise by factor 2.4 and 5.1 in the acclimatization and non-acclimatization approach, respectively. Even though there is substantial variability across the individual model simulations, it is most likely that the future burden of heat will increase considerably. The obtained results point to public health interventions to reduce the vulnerability of the population to heat waves. Quelle: http://www.mdpi.com