cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of maternal verbal sensitivity during parent-child shared book reading in socio-emotional functioning in the preschool years
Creators: name: Kim, Hillary Mi-Sung
Publisher: name: No Publisher Supplied
Year: 2012

description: The concept of maternal sensitivity has shifted over time to include a focus on engagement with the child at a mental level in addition to physical and emotional care. This study investigates this idea, using data from the Early Childhood Longitudinal Study-Birth Cohort. Maternal verbalization was captured using the Reading Aloud Profile–Together coding during mother-child book reading. Findings using latent class analyses showed that mothers could be classified into two distinct classes having different verbalization styles. Identified maternal verbal sensitivity was marked by bringing her child‘s world into communication and by facilitating the child to engage in communication, asking both close- and open-ended questions; whereas, less sensitivity at the verbal level was marked by focusing on the book rather than the child‘s experiences. The predictive validity of maternal verbal sensitivity was supported as it was positively associated with the child‘s social competence as rated by mothers, while at the same time being negatively associated with the child‘s externalizing behaviors as rated by both mothers and early care/education providers. This study fills a gap in the literature concerning correlates of maternal verbal interactive styles. Its findings suggest that maternal verbal sensitivity is a behavior not depending on contextual factors. Its findings also support Ainsworth‘s conceptualization of maternal sensitivity—a capacity to tailor responses to the child‘s individuality. Importantly, the overall findings showed the moderating role of maternal verbal sensitivity on the relation between mother/child background characteristics and the child‘s socio-emotional functioning, suggesting the effectiveness of interventions utilizing mother-child dyadic book-reading contexts. Furthermore, the findings imply that preschoolers have come to refine or re-organize the internal working models of the social worlds in the context of mother-child communication, which supports theoretical notions posited by attachment researchers. Finally, the findings underscore the methodological advantages of a person-level approach in investigating a new construct which is exploratory in nature and empirically driven. This study looked at the constellation of verbalizations at the person-level, thereby yielding the information about the complexity of them.
Myotis bocagii
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Myotis
Myotis bocagii

description: Myotis bocagii (Peters 1870)
Six specimens were captured at two sites
(foothills of Mount Namuli and the shores of Lake
Niassa) in northern Mozambique. Previously, one specimen was recorded from central Mozambique (Smithers and Lobão Tello, 1976).
Field measurements: FA (adult male) 38.9 (1); Bm (adult male) 9.0 (1); FA (adult female) 40.8 ± 1.48 (39.3–42.8, 4); Bm (adult female) 9.8 ± 0.65 (9.0–10.5, 4).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on page 383, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Mycodrosophila projectans Sturtevant 1916
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Mycodrosophila
Mycodrosophila projectans

description: projectans (Sturtevant), 1916: 342 (Drosophila). Type locality: Dominican Republic, San Francisco, Mts. HT M (USNM). NT Distr.: Dominican Republic, Mexico, Colombia. Ref. Wheeler & Takada, 1963: 395.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 735, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Mobula mobular
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Myliobatidae
Mobula
Mobula mobular

description: Mobula mobular (Bonnaterre 1788)
Giant Devilray
Raia mobular Bonnaterre, 1788: 5. No types known. Type locality: Montredon, near Marseille, France, Mediterranean Sea.
Local synonymy: White et al., 2018: 290, figs (PNG).
PNG voucher material: None.
Remarks: No confirmed PNG specimens recorded, but recorded in the bycatch of the purse seine fishery. It is one of the most abundant devilrays in pelagic fisheries in tropical Western Central Pacific waters, thus its presence in PNG is very likely. Previously thought to be restricted to the Mediterranean Sea, White et al. (2017b) found that M. japanica (Müller & Henle, 1841) was conspecific, thus a circumglobal species.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 68, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
“Nobody couldn't sell'em but her"
Creators: name: Jones-Rogers, Stephanie Elizabeth
Publisher: name: No Publisher Supplied
Year: 2012

description: Historians richly document white women’s social, ideological, and cultural roles within nineteenth-century slaveholding households and communities, yet they rarely consider their economic relationships to slavery. Scholars also recognize enslaved people’s understandings of how profoundly male slaveowners’ economic decisions affected their lives, but they neglect enslaved people’s knowledge about how female slaveownership—not just domestic management—shaped their experiences in bondage as well. Drawing upon slaveowners’ correspondence, slave trader’s papers, ex-slave narratives, travel writing, illustrations, newspapers, city and business directories, financial records, as well as legal and military documents, my dissertation examines the ways that gender shaped white married women’s experiences of slaveownership in the nineteenth century, it demonstrates how slaveownership afforded them particular kinds of power that pivoted upon the right to enslave and own human beings, and it sees white slaveowning women and their economic activities through the eyes of the enslaved African-Americans who served them.
Mobula tarapacana
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Myliobatidae
Mobula
Mobula tarapacana

description: Mobula tarapacana (Philippi, 1892)
Chilean Devilray
Cephaloptera tarapacana Philippi, 1892: 8, Pl. 3 (fig. 2). Holotype: whereabouts unknown. Type locality: 12 miles west of Iquique, Tarapacà Province, Chile.
Local synonymy: White et al., 2018: 292, figs (PNG).
PNG voucher material: None.
Remarks: No confirmed PNG specimens recorded, but recorded in the bycatch of the purse seine fishery. It is a distinctive and regularly caught devilray in pelagic fisheries in tropical Western Central Pacific waters, thus its presence in PNG is very likely.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 68, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Role of microRNAs in the Pathogenesis of AIDS-NHL
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Individuals infected by HIV are at an increased risk for developing non-Hodgkin's lymphomas (AIDS-NHL). Even though effective anti-retroviral treatment exists, the incidence of AIDS-NHL has not decreased as much as other AIDS-related clinical conditions, and AIDS-NHL remains a significant problem. Recently, a lot of attention has been directed to the role of microRNA (miRNA) in cancers, including lymphomas. miRNAs are small RNAs that can inhibit the expression of cellular genes. Thus, by inhibiting crucial genes involved in the regulation of cell cycle, growth, differentiation, and death, miRNAs can contribute to the development of cancers, including lymphoma. This proposal aims to define the miRNA expression pattern seen in normal and malignant B cell populations; determine if a miRNA expression signature exists in HIV infected individuals and whether malignancy associated miRNAs precede the development of AIDS-NHL. Finally, we hope to identify and verify the target genes for these malignancy associated miRNAs, to provide insights as to how perturbations in miRNA expression may promote cancer. Overall, work from this proposal may lead to identification of unique malignancy associated miRNAs that would provide new information on identification, management, and treatment strategies for AIDS-NHL.
SIMLI VA SIMSIZ ALOQA VOSITASI
Creators: name: Xushvaqtov, Diyorbek
name: Nurullayeva, Malika
name: Yaxiyoxonova, Muhiba
Publisher: name: Zenodo
Year: 2025

description: Simli va simsiz aloqa vositalari sohasi tobora rivojlanib bormoqda, shuning uchun mavzuga oid adabiyotlar ham turli-tuman va keng koʻlamli. Ushbu adabiyotlar tahlili maqola yozish uchun zarur boʻlgan turli xil manbalarni va ularning asosiy yoʻnalishlarini koʻrsatib beradi. Simli aloqa vositalari — bu maʻlumotlarni uzatish uchun simlar yoki kabellardan foydalanadigan aloqa uslublaridir. Ushbu vositalar, asosan, telecomunications sohasida keng qoʻllaniladi va ular maʻlumotlarning uzatilishi, televidenie signallari, ovozli aloqa va boshqa koʻplab servislar uchun muhim ahamiyatga ega.
Livre de Caisse
Creators: name: Bourcard Fils et Cie
Publisher: name: [s.n.]
Year: 1812

description: Verzeichnung=Description=Inventaire 14.03.2017 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Modulation of breast cancer stem cell response to radiation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A major reason for failures in cancer therapy is an incomplete elimination of a special type of cell, termed cancer stem cells (CSCs). The CSC model argues that tumors arise from cells that retain the properties of adult stem cells, particularly for their ability to self-renew and differentiate into multiple cell types, often seen as the heterogeneity of cell types in patient samples. In addition, CSCs persist in tumors as a distinct population and they account for disease relapse and metastasis. The CSCs represent only 1-2% of the total tumor cell population, but are thought to be highly resistant to conventional chemotherapy and radiotherapy. However, the exact phenotype of breast CSCs is still undefined, and their mechanisms for escaping effective therapy continue to elude researchers.

 In breast cancer, a breast cancer initiating cell population (BCIC), highly enriched for CSCs, can be identified and propagated from patient samples and from established breast cancer cell lines. Therefore, we will use BCICs with the understanding that our results will include CSCs and other early progenitor cells at the same time. We hypothesize that: (1) CSCs exhibit increased radiation resistance based on increased levels of radical scavengers, (2) BCICs create and restore their own stem cell niche, and (3) the size of the stem cell pool and the fate of these cells is determined by co-dependency with the signaling stem cell niche, which provides a potential target for improving radiotherapeutic outcome. For our studies cancer stem cells will be isolated from MCF-7 and T-47D breast cancer cell lines and from ER+ breast cancer patient specimens. The cells will be propagated under serum-free conditions as hollow balls of cells, called mammospheres. Radiation response will be determined by flow cytometry, TUNEL-assays to measure programmed cell death (apoptosis), and clonogenic assays (i.e., studying the effectiveness of specific agents on the proliferation of cells). Radiation-induced signal transduction in breast cancer stem cells involving Notch, a membrane protein controlling cell differentiation, will be monitored using flow cytometry and Western blotting. The goal is to compare the radiosensitivity of breast cancer stem cells to non-stem cells from established cell lines and patient specimens, and develop a mechanistic explanation for these differences with the goal of pointing the way for new approaches to increase radiation sensitivity specific to CSCs.

 Currently, radiation is a safe and efficient breast cancer therapy and co-determines treatment success and cosmetic outcome. However, despite technical advances in radiation therapy, disease recurrence remains almost unchanged over the last three decades. We hope that studying the response of breast CSCs to therapy will lead to improvements in treatment.
Chimaeridae Rafinesque 1815
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Chimaeriformes
Chimaeridae

description: Family Chimaeridae Rafinesque, 1815
Shortnose Chimaeras
Genus Chimaera Linnaeus, 1758 Chimaeras
Chimaera Linnaeus, 1758: 236. Type Chimaera monstrosa Linnaeus, 1758, by Linnaean tautonymy.
Chimaera ogilbyi Waite, 1898 Ogilby’s Chimaera
Chimaera ogilbyi Waite, 1898: 56, Pl. 11. Syntypes: AMS I.3732, AMS I.3724, AMS I.3736, AMS I.3737. Type locality: off Sydney, New South Wales, Australia.
Local synonymy: Hydrolagus ogilbyi— Fricke et al., 2014: 16 (Madang Province). Chimaera ogilbyi— Finucci et al., 2018: 191, fig. 5d (East Sepik Province); White et al., 2018: 294, figs (PNG).
PNG voucher material: (2 spec.) NTUM 10332, juvenile male 362 mm TL, 129 mm body length, NTUM 10333, female 287 mm TL, 109 mm body length, west of Kairiru Island, East Sepik Province, 3°20’S, 143°28’E, 378–495 m depth, 19 Dec. 2012.
Remarks: First recorded from PNG by Fricke et al. (2014), based on NTUM 10332 and 10333 collected in 2012; note that these were collected from off the East Sepik Province and not Madang and thus was probably confused with the Hydrolagus cf. mitsukurii specimen (see below) which was taken from off Madang. Despite some molecular differences, these specimens are morphologically identical with Australian C. ogilbyi specimens and were considered conspecific by Finucci et al. (2018). Previously placed in the genus Hydrolagus.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 69, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Livre de Caisse
Creators: name: Bourcard Fils et Cie
Publisher: name: [s.n.]
Year: 1810

description: Verzeichnung=Description=Inventaire 14.03.2017 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Mycodrosophila pseudoprojectans Wheeler & Takada 1963
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Mycodrosophila
Mycodrosophila pseudoprojectans

description: pseudoprojectans Wheeler & Takada, 1963: 395. Type locality: Nicaragua, El Recreo. HT M (USNM). Distr.: Colombia (Amazonas, Leticia), Nicaragua, Panama.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 735, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Myotis tricolor
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Myotis
Myotis tricolor

description: Myotis tricolor (Temminck 1832)
This species was collected from the foothills and plateau of Mount Namuli, Mount Mabu and Mount Chiperone in northern Mozambique. Two prior records exist for central Mozambique (Smithers and Lobão Tello, 1976).
Field measurements: FA (adult male) 49.9 (48.0–51.7, 2); Bm (adult male) 13.5 (13.0–14.0, 2).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Flos-aquae in Potable Waters : Laboratory Equivalents for Toxic Degradation
Creators: name: Garg, Rishabh
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310701
subject: Bacteriology

description: Toxic degradation of Aphanizomenon flos-aquae (commonly known as "flos-aquae") in drinking water occurs when this cyanobacteria species dies and breaks down, releasing harmful cyanotoxins that can pose health risks if ingested. This process is considered toxic due to the release of these dangerous compounds. While there are various methods to reduce toxicity, ionization at the end of the filtration process may be an effective solution to eliminate microbial species and their associated organoleptic properties.
Hydrolagus Gill 1862
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Chimaeriformes
Chimaeridae
Hydrolagus

description: Genus Hydrolagus Gill, 1862
Ghostsharks
Hydrolagus Gill, 1862: 331. Type species Chimaera colliei Lay & Bennett, 1839, by monotypy.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 69, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Neoromicia capensis
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Neoromicia
Neoromicia capensis

description: Neoromicia capensis (A. Smith 1829)
Four specimens were captured at two sites in central Mozambique. It was previously widely recorded from southern and central Mozambique (Smithers and Lobão Tello, 1976).
Field measurements: FA (adult male) 34.5 (32.7–36.3, 2); Bm (adult male) 7.5 (7.0–8.0, 2); FA (adult female) 36.4 (35.8–37.0, 2); Bm (adult female) 7.8 (7.5–8.0, 2).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Neoromicia nana
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Neoromicia
Neoromicia nana

description: Neoromicia nana (Peters 1852)
This common species was netted at 12 sites throughout Mozambique, making it the most widespread species encountered during this study. It was found characteristically roosting within a rolledup banana leaf at the base of Mount Mabu. Riccucci and Lanza (2008) showed that the genus name Neoromicia is feminine, and therefore the species name should be N. nana (this species was previously known by the masculine form of N. nanus).
Field measurements: FA (adult male) 30.1 ± 1.90 (26.7–32.5, 22); Bm (adult male) 3.4 ± 0.44 (3.0– 4.0, 21); FA (adult female) 30.7 ± 1.50 (27.7–32.0, 22); Bm (adult female) 4.1 ± 1.08 (3.0–6.5, 21).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Hydrolagus mitsukurii
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Chimaeriformes
Chimaeridae
Hydrolagus
Hydrolagus mitsukurii

description: Hydrolagus cf. mitsukurii
Papuan Ghostshark
Local synonymy: White et al., 2018: 296, figs (PNG).
PNG voucher material: (2 spec.) NTUM 10331, female 281 mm PCL, Astrolabe Bay, Madang, 5°21’S, 145°49’E, 520–575 m depth, 14 Dec. 2012.
Remarks: First record of this species and genus from PNG; generic placement tentative. Similar to Hydrolagus africanus (Gilchrist, 1922) and H. mitsukurii (Jordan & Snyder, 1904); more specimens needed to confirm its identity.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 69, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Neoromicia rendalli
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Neoromicia
Neoromicia rendalli

description: Neoromicia rendalli (Thomas 1889)
A single specimen was captured in southern Mozambique, which constitutes the third record of this species for the country (Monadjem et al., 2010).
FA (adult female) 37.6 (1); Bm (adult female) 9.5 (1).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
ADOLESCENT NICOTINE AND CANNABINOID EXPOSURE ON NICOTINE DEPENDENCE
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco addiction imposes a significant negative impact on the health and economic status of the individual and society. This research proposal will investigate whether exposure to nicotine or cannabinoids during youth alters later drug taking and relapse-related behaviors in adulthood. Together, these data may reveal fundamental insights into the effects of adolescent drug use on vulnerability to develop tobacco/nicotine addiction later in adulthood. By establishing this model, future investigations may thus identify the mechanisms underlying nicotine reinforcement and dependence, and importantly, may lead to the development of novel therapeutics efficacious for smoking cessation in humans.
APOBEC3 Restriction of Retroviral Infection in Small Animals
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV is a “complex retrovirus” that specifies several “accessory” proteins that assist it in its infection process. One of the accessory proteins is Vif, which has been recently been shown to counteract a normal cellular defense system – the APOBEC proteins. Studies would be greatly facilitated by the availability of a small animal model to study the APOBEC system. We will develop specially engineered mice that lack a crucial APOBEC gene to study infection by a simple mouse retrovirus, murine leukemia virus. The biological effects can be rapidly and sensitively studied in infected mice. The results from these experiments may lead to a powerful new approach to studying APOBEC defense agains HIV.
Preservation of the slave sites on West Africa’s coast
Creators: name: Johnson, Stephanie A.
Publisher: name: No Publisher Supplied
Year: 2012

description: This thesis will explore the history and cultural heritage of the structures and sites along the West African coast, occupied by Europeans during the trans-Atlantic Slave Trade. It may appear overly ambitious to study the entire West African coast, but this will present a brief history of the development of the site, their structures and the slave trade. I will focus on efforts made by international organizations and African nations to preserve the structures as well as their efforts to create memorial museums. This research is based upon secondary research, such as scholarly books, articles, reports by archaeologists who have worked on the sites, and data collected from organizations such as the United Nations Educational, Scientific, and Cultural Organization (UNESCO). These structures and sites are material evidence of the slave trade and the early African-European encounter. Using four sites as case studies: Bunce Island, Sierra Leone; Savi, Benin; Goree Island, Senegal; and St. George Elmina, Ghana, I will discuss the existing practice of preserving the sites as memorial museums. The preservation of these sites are increasingly necessary due to the influx of tourists of African descent travel to West Africa in an attempt to find their “roots.” Some sites have received more attention and visitation than others. Slavery and the slave trade dominate the narratives of the sites, which raise questions of authenticity because most of the information is provided through oral tradition. Adequate historical and archaeological research in the area of the sites must be made to prove their legitimacy as slave structures.
Neoromicia zuluensis
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Neoromicia
Neoromicia zuluensis

description: Neoromicia zuluensis (Roberts 1924)
This species was recorded at four sites in central and northern Mozambique.
Field measurements: FA (adult male) 30.6 ± 1.15 (29.7–31.9, 3); Bm (adult male) 4.0 ± 0 (4.0, 3); FA (adult female) 30.0 ± 1.18 (28.8–31.2, 4); Bm (adult female) 4.1 ± 0.25 (4.0–4.5, 4).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Inhibitors of Condensin I as chemotherapy for breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Condensin I is an essential protein complex required for chromosome structural organization in both mitosis and interphase. Depletion of condensin I results in chromosome segregation defects. In addition, condensin I functions in interphase (period of cell cycle between division phases) in DNA repair, although the underlying molecular mechanism is not completely understood. Interestingly, condensin I functionally interacts with critical cancer drug targets, namely topoisomerase II (essential in the separation of daughter strands at the end of replication) and PARP-1 (key protein involved in repairing DNA damage). This raises the important possibility that condensin I may also be an effective target for breast cancer therapy.

 Thus, we plan to develop small molecules that disrupt chromosome association and/or the DNA repair function of condensin I and test their efficacy on breast cancer cell proliferation and damage sensitization. Our aims are to: (1) perform high-throughput screening to identify chemical compounds that inhibit condensin I function, and (2) to refine and analyze the biological activities of the identified compounds.

 Based on our preliminary data and work by others, we plan to use three assays to screen the small molecule library for possible inhibitors that can compromise condensin I function. Since condensin I must physically interact with chromosomes to mediate higher-order chromatin organization important for mitosis and interphase functions, we will use a cell-based method to monitor the mitotic chromosome association of fluorescently-labeled condensin I components in the presence of the library compounds. The second portion of the project entails a protein binding assay to monitor possible disruption of the condensin I subunit CNAP1/hCAP-D2 HE domain interaction with PARP-1 by the addition of compounds. Our final assay is a reverse yeast two-hybrid screening that will complement the in vitro protein binding assay. By using both cell biological and biochemical assays, we should be able to maximize the chance to identify condensin I inhibitors.

 Our strategy of investigating a condensin I pathway directly involving PARP-1 is the most logical approach, since PARP-1 has already shown great promise as a new therapeutic target. In particular, patients having defects in BRCA 1 or 2 pathways (called “BRCAness” in sporadic breast cancers) depend almost exclusively on PARP-1 for DNA repair functions, so inhibitors of PARP-1, or any associated pathways, are very promising avenues for developing novel treatments.
Neotanygastrella Duda
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Neotanygastrella

description: Genus Neotanygastrella Duda
Neotanygastrella Duda, 1925: 206. Type species, Neotanygastrella tricoloripes Duda, MO.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 735, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Improved Specificity for Breast Cancer: A Combined System
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Although mammography is very sensitive in detecting early breast cancer, it does not work well in women who have dense breast tissues, breast implants, or scar tissues due to previous treatment. It has been proven that dynamic contrast enhanced (DCE) MRI detects malignant cancers which are occult on mammogram and ultrasound, and as such it has becoming the most popular imaging modality for screening young women. DCE-MRI is also considered as the most sensitive detection modality in women who have breast implants, or scar tissues. However, despite its high sensitivity, DCE-MRI also detects many benign lesions. The low specificity may lead to great anxiety to patients, and unnecessary biopsy or over-treatment. There is a great need to develop another imaging modality that can provide supplemental information to improve the specificity of DCE-MRI, particularly for young women.

 In this study, we propose to develop a novel breast-imaging platform to provide co-registered tri-modality imaging capability: Optical Imaging (OI), DCE-MRI and MR spectroscopy (MRS). As an adjunct to another imaging modality, the OI systems can provide valuable complementary information, particularly in patients whom the conventional imaging is less optimal, such as young women with dense breasts. Moreover, MRS can provide the choline levels in the lesions, which is elevated in malignant lesions compared to benign lesions. We believe that the combination of OI and MRS with DCE-MRI will allow a better characterization of breast lesions, thus an improved specificity, due to enhanced information gathered by this multi-modality system.

 Our first aim is to develop a combined Ol, MRI, and MRS human breast cancer imager. Our second aim is to test and evaluate the tri-modality system with phantom studies. Once the combined system is optimized with ex-vivo studies, the performance of the system will be evaluated with human studies. At the end of the study, the performance of DCE-MRI, DCE-MRI + MRS and the tri-modality system in distinguishing benign and malignant breast cancer tumors will be assessed.
In Vivo MRS for Cancer Diagnosis and Treatment Monitoring
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Compared to conventional breast examinations (clinical, mammography, and ultrasound), MRI has been proven to be the most sensitive imaging modality for detecting invasive cancer in dense breast or breast with implants. It is fast becoming the optimal choice for screening young women at a high risk of developing breast cancer. However, despite its high sensitivity, MRI also detects many incidental lesions. The false positive finding may lead to a great anxiety to patients, and in many cases unnecessary biopsies or over-treatment. Other adjunct imaging modalities that can achieve a higher diagnostic accuracy, especially in women with dense breasts, are greatly needed.

 Magnetic resonance spectroscopy (MRS) is a non-invasive technique that provides information about tumor metabolism. We will investigate in vivo quantification of choline [choline and its metabolites are needed for structural integrity and signaling roles for cell membranes, neurotransmission (acetylcholine synthesis), and as a major source for methyl-groups] levels in benign, in-situ and invasive cancers. Two hypotheses will be tested: (1) whether the additional information measured by MRS may improve the specificity of MRI (morphological and kinetic enhancement characteristics) in differentiating benign from malignant tumors, and (2) whether the addition of metabolic changes to MRI morphological and kinetic parameters will enhance the prediction of complete response in patients receiving neoadjuvant chemotherapy. To evaluate the potential of our MRS approach, we will include patients: (1) with inoperable locally advanced breast cancer, (2) with clinically documented lymph node involvement, and (3) those with down-staged tumors to facilitate breast conservation surgery.

 The innovative component is the quantification of in vivo MRS and morphologic and enhancement kinetic parameters in MRI for diagnosing breast cancer and monitoring neoadjuvant chemotherapy efficacy Ultimately this quantitative method can be developed to provide an MRI Computer-Assisted Detection (CAD) system. The success of this study may have beneficial effect by potentially reducing negative biopsies and provide a better treatment for each individual patient and reduce side effects caused by ineffective therapies.
Nycticeinops schlieffeni
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Nycticeinops
Nycticeinops schlieffeni

description: Nycticeinops schlieffeni (Peters 1859)
This species was collected from nine sites across the country. It was previously collected from southern and central Mozambique (Smithers and Lobão Tello, 1976).
Field measurements: FA (adult male) 30.9 ± 0.42 (30.6–31.4, 3); Bm (adult male) 6.0 ± 0.50 (5.5–6.5, 3); FA (adult female) 31.4 ± 1.16 (29.6–33.2, 13); Bm (adult female) 5.7 ± 0.82 (5.0–7.0, 11).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Improving Healthcare for Indonesian Men Living with Type-2 Diabetes Mellitus and Associated Erectile Dysfunction
Creators: name: Hadisuyatmana, Setho
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 320101
subject: Cardiology (incl. cardiovascular diseases)
classificationCode: 420305
subject: Health and community services
classificationCode: 420309
subject: Health management

description: Submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy to the School of Psychology and Public Health, La Trobe University, Victoria, Australia.
CDK regulated transcriptional repression by Efg1 in Candida
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Oropharyngeal candidiasis (OPC) is the most frequent oral manifestation of HIV infection. It is seen in 50-90% of AIDS patients. Azole antifungal agents are the current mainstay of therapy for OPC. However, because of the rapid emergence of azole resistance, it is necessary to develop novel strategies to prevent and treat oropharyngeal candidiasis. Candida albicans grows in a variety of morphological forms ranging from a budding yeast to an elongating hypha, depending on the environmental conditions. Such morphological flexibility plays a central role in the pathogenicity of this fungus. Mutant strains unable to produce hyphae are avirulent in mice. A transcription factor, Efg1 (Enhanced Filamentous Growth 1) plays a major role in regulating hyphal development in C. albicans. Mutations that inactivate Efg1 block hyphal development and are avirulent in mice. Despite the importance of this transcription factor, little is known about its regulation and exact functions. The objective of this research is to determine how Efg1 activity is regulated in C. albicans, and to find out the significance of this regulation during hyphal morphogenesis. This work will further our understanding of C. albicans morphogenesis and its pathogenesis. The knowledge gained will be useful in the future when developing new methods to combat oropharyngeal candidiasis.
Historical Geodata for Pre-Modern China - A Case Study of the CHGIS Project
Creators: name: Merrick Lex Berman
Publisher: name: Zenodo
Year: 2004

description: The China Historical GIS (CHGIS) has been developing a base GIS framework of all the recorded administrative divisions for dynastic China, from the unification of the first Chinese Empire (222 BCE) to the fall of the last Dynasty (1911 CE). The CHGIS project is not producing or incorporating historical statistics for these administrative units, but is specifically focused on the more fundamental matter of compiling all administrative units into a single geospatial database. Each unique historical unit is defined with: a date range, a place name, a feature type, a source citation, a relationship to its parent jurisdiction, and an associated spatial object in GIS. The CHGIS project developed a relational data model for keeping track of historical places and documented sources as they changed over time. Many technical hurdles and system integration issues had to be dealt with, including: developing a search engine for the Web with guide maps, defining spatial objects for ancient places, system integration of multilingual datasets, and testing semantic interoperability between feature type thesauri. We hope that our experiences and the CHGIS datasets themselves will be of interest to everyone dealing with digital sources of historical geographic information. We also welcome collaboration in the development of application methods that can be used together with our base GIS framework.
Host-Commensal Dynamics in HIV infection
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It’s estimated that the gastrointestinal tract (GIT) is home to 100 trillion bacteria. These commensal, organisms help us to absorb nutrients from food, prevent colonization by pathogenic bacteria, and maintain the function of our GI immune response. Increasing evidence supports the idea these commensal bacteria play a critical role in the maintaining our GIT by a crosstalk of signals to the gut epithelial barrier and the mucosal immune system. However, inflammation can disrupt this crosstalk leading to GI complications. The GIT is severely damaged by Human Immunodeficiency Virus (HIV). The rapid depletion of CD4 T cells, damage to the epithelial barrier, and changes to microbial composition of the GIT is observed in HIV infection. As HIV infection progresses the defects in the GIT results in the translocation of bacteria or bacterial products from the gut into the systemic circulation. In addition, the depletion of CD4 T cells leads to an increase in opportunistic infections in chronic HIV infection. Some commensal bacteria have probiotic properties that can help improve the condition of the GIT. Lactobacillus plantarum (L. plantarum) is a commensal bacteria that is known to dampen inflammatory responses as well as strengthen the integrity of the epithelial barrier. This has lead to clinical trials involving the treatment of HIV patients with probiotic therapies. However, whether probiotics are able to function normally in chronically infected patients due to changes in the bacteria or in the host and how it perceives the signals from the bacteria. In this study we test the idea that SIV infection causes an inflammatory environment in the GIT. As a result, commensal bacteria may change their gene expression profiles in response to the inflamed environment. In addition we hypothesize that the signaling pathways that are involved in the host-commensal crosstalk is modified such that there is a loss of the beneficial effects of L. plantarum in chronic HIV infection. To accomplish this we will be using the Simian Immunodeficiency Virus (SIV) model of HIV infection. We will inject L. plantarum into the small intestine of SIV infected rhesus macaques and then retrieve the intestinal content after five hours to sequence the changes in gene expression by the bacteria. We will also take gut samples to look at the protein expression of various components of the signaling pathways that are utilized when L. plantarum interacts with the host. This study presents an opportunity to understand how the relationship between the GIT and commensal bacteria changes with HIV infection. By identifying the defects, we can start to develop therapies that can restore the host-commensal relationship and repair the GIT.
Neotanygastrella chymomyzoides Duda 1927
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Neotanygastrella
Neotanygastrella chymomyzoides

description: chymomyzoides Duda, 1927: 71. Type locality: Bolivia, La Paz, Mapiri, Sarampioni, 700m. LT M (SMT). NT Distr.: Widespread in Neotropics. Ref.: Wheeler, 1957:105
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 735, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
MRI Registration for Therapy Evaluation and Annual Screening
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast MRI has gradually evolved from a research tool to an important clinical imaging modality. To improve performance and reduce costs, computer-aided analysis tools are urgently needed. One example is to compare images taken from the same woman at different times. This is important to monitor breast density changes in high-risk women, or for monitoring the response of cancer patients who will receive neoadjuvant chemotherapy (NAC) to shrink tumors before surgery. Due to the highly deformable nature of breast, the MRIs taken at different times often present breast images of different shapes, so the comparison difficulty level is much higher than for mammograms. Unfortunately, none of the commercial breast MRI analysis tools provide such a comparison-image registration function.

 Thus, this project will contribute in two areas of breast disease imaging evaluation; 1) NAC response and changes in breast density, and 2) development of computer-aided technology.

 Our specific aims are to develop:

 1) various registration algorithms for different situations where the object boundary and possibly some internal landmarks are available, and validate these algorithms using properly designed phantom (i.e., simulated breast tissue) studies.

 2) 4-D (3 spatial dimensions plus time) breast MR registration for augmenting response evaluation in patients receiving NAC. The planned computer-aided tool will follow radiologists’ interpretation steps based on spatially co-registered images.

 3) a computer-aided tool to detect the local changes of fibroglandular tissues in normal breasts.

 The new image analysis tools will be applied to serial MRI studies performed from the same patients (NAC patients and normal volunteers) at different times to measure local changes of breast density. The registration quality of the breast will be first investigated, and when satisfactory, the registration of fibroglandular tissue will be performed to analyze the shrinkage and expansion of dense regions.

 This research may benefit patients who choose to receive NAC, and the status for high-risk women who are recommended to receive annual breast MRI for screening.