cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The inotropic and arrhythmogenic effects of acutely increased late INa are associated with elevated ROS but not oxidation of PKARIα
Creators: name: Gissibl, Theresa
name: Stengel, Laura
name: Tarnowski, Daniel
name: Maier, Lars S.
name: Wagner, Stefan
name: Feder, Anna-Lena
name: Sag, Can Martin
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: PKARIα, excitation contraction coupling (ECC), CaMKII, oxidative stress, L-type Ca2+ current (ICa)
subject: 610 Medizin

description: Background: Acute stimulation of the late sodium current (INaL) as
pharmacologically induced by Anemonia toxin II (ATX-II) results in
Na+-dependent Ca2+ overload and enhanced formation of reactive oxygen
species (ROS). This is accompanied by an acute increase in the amplitude of
the systolic Ca2+ transient. Ca2+ transient amplitude is determined by L-type
Ca2+-mediated transsarcolemmal Ca2+ influx (ICa) into the cytosol and by
systolic Ca2+ release from the sarcoplasmic reticulum (SR). Type-1 protein
kinase A (PKARIα) becomes activated upon increased ROS and is capable of
stimulating ICa, thereby sustaining the amplitude of the systolic Ca2+ transient
upon oxidative stress.
Objectives: We aimed to investigate whether the increase of the systolic Ca2+
transient as acutely induced by INaL (by ATX-II) may involve stimulation of ICa
through oxidized PKARIα.
Methods: We used a transgenic mouse model in which PKARIα was made
resistant to oxidative activation by homozygous knock-in replacement of redoxsensitive
Cysteine 17 with Serine within the regulatory subunits of PKARIα (KI).
ATX-II (at 1 nmol/L) was used to acutely enhance INaL in freshly isolated
ventricular myocytes from KI and wild-type (WT) control mice. Epifluorescence
and confocal imaging were used to assess intracellular Ca2+ handling and ROS
formation. A ruptured-patch whole-cell voltage-clamp was used to measure
INaL and ICa. The impact of acutely enhanced INaL on RIα dimer formation and
PKA target structures was studied using Western blot analysis.
Results: ATX-II increased INaL to a similar extent in KI and WT cells, which was
associated with significant cytosolic and mitochondrial ROS formation in both
genotypes. Acutely activated Ca2+ handling in terms of increased Ca2+ transient
amplitudes and elevated SR Ca2+ load was equally present in KI and WT cells.
Likewise, cellular arrhythmias as approximated by non-triggered Ca2+ elevations
during Ca2+ transient decay and by diastolic SR Ca2+-spark frequency occurred
in a comparable manner in both genotypes. Most importantly and in contrast to
our initial hypothesis, ATX-II did not alter the magnitude or inactivation kinetics
of ICa in neither WT nor KI cells and did not result in PKARIα dimerization (i.e.,
oxidation) despite a clear prooxidant intracellular environment.
Conclusions: The inotropic and arrhythmogenic effects of acutely increased INaL
are associated with elevated ROS, but do not involve oxidation of PKARIα.
Euneomys mordax Thomas 1912
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Euneomys
Euneomys mordax

description: Euneomys mordax Thomas 1912
Euneomys mordax Thomas 1912, Ann. Mag. Nat. Hist., ser. 8, 10: 410.
Type Locality: Argentina, Fort San Rafael; location uncertain, probably not the San Rafael in Mendoza Prov. (see remarks by Pearson and Christie, 1991:126, and Reise and Gallardo, 1990:79).
Vernacular Names: Large Euneomys.
Synonyms: Euneomys noei Mann 1944.
Distribution: WC Argentina (Mendoza and Neuquen Provs.) and adjacent region of Chile (Santiago, Bío-Bío, and Araucanía Provs.), apparently at higher elevations (1740-3000 m); range limits unknown.
Conservation: IUCN – Lower Risk (lc).
Discussion: Clearly a species distinct from the chinchilloides petersoni complex as conveyed by its large size, singular pattern of incisor grooving, and chromatic differences (Pearson and Christie, 1991; Reise and Gallardo, 1990). Pearson and Christie (1991) treated noei as conspecific with E. mordax, but Reise and Gallardo (1990) considered it a subjective synonym of E. chinchilloides. The former allocation is supported by the sulcation of the upper incisors (a wide, shallow trough about centrally positioned) that characterizes the holotype (USNM 391817); although a subadult, the dimensions of the molars, interorbit, and braincase describe a large animal, one fully as robust as E. mordax (e.g., examples from La Parva; USNM 399400, 399401). At the type locality (Valle de la Junta, Lo Valdes, 2500 m), the holotype was collected with another specimen (USNM 391818) that is referable to the chinchilloides petersoni complex, as suggested by its incisor groove (a narrow crease situated mediolaterally), smaller size of those same cranial dimensions, and narrower breadth of the incisors and distal nasals. Pearson and Christie (1991) recorded other sites of sympatry or parapatry between E. mordax and the chinchilloides petersoni complex (all identified as E. chinchilloides by them) in Chile (La Parva, vicinity of Paso Pino Hachado) and Argentina (vicinity of Copahue, Cueva Traful). Karyotype (2n = 42, FN = 66) reported by Reise and Gallardo (1990) based on a voucher from Paso Pino Hachado; its identity should be reconfirmed.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1115, DOI: 10.5281/zenodo.7316535
title: Activité du port de Saint-Malo – 1750 – Saint-Sébastien
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: poissons
subject: minerais et métaux
subject: produits manufacturés

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1750 avec le port "Saint-Sébastien"
description: Marchandises au départ de Saint-Malo : morues sèches ; étain
description: Catégories de marchandises au départ de Saint-Malo : produits de la mer ; poissons ; minerais et métaux
description: Marchandises arrivées à Saint-Malo : fer ; avirons
description: Catégories de marchandises arrivées à Saint-Malo : minerais et métaux ; produits manufacturés
description: Coverage: Grand commerce
description: Bibliographic citation: LUCAS, Marie-France. Le Commerce maritime de Saint-Malo en 1750. DES : Histoire : Rennes : 1966 (Bibliothèque François-Lebrun, MH 1041)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Romalea microptera
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Romaleidae
Romalea
Romalea microptera

description: Romalea microptera
“Eastern lubber grasshopper”
Figures 63 (lateral), 64 (dorsal, ventral)
Plates 38 (lateral), 39 (dorsal), 40 (ventral)
The tracheal structure of the lubber grasshopper Romalea microptera features a substantial number of air sacs, integrated into the tracheal system, and discrete air cells distributed throughout the body, especially the head and thorax. Due to the complexity of the tracheal architecture of Romalea, only spiracles and major tracheae are labeled in the plates. 3D models are provided in the supplementary digital data for further investigation.
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
Euneomys petersoni J. A. Allen 1903
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Euneomys
Euneomys petersoni

description: Euneomys petersoni J. A. Allen 1903
Euneomys petersoni J. A. Allen 1903, Bull. Am. Mus. Nat. Hist., 19: 192.
Type Locality: Argentina, Santa Cruz Prov., upper Río Chico, near the Cordilleras.
Vernacular Names: Peterson's Euneomys.
Synonyms: Euneomys dabbeni Thomas 1919.
Distribution: WC Argentina (Neuquen Prov.) and C Chile (Santiago Prov.) southwards to extreme S Argentina and adjacent Chile, excluding Tierra del Fuego; limits uncertain.
Conservation: IUCN – Lower Risk (lc).
Discussion: Relegated to a subspecies or full synonym of E. chinchilloides by most systematists (Gyldenstolpe, 1932; Hershkovitz, 1962; Mann, 1978; Muñoz Pedreros, 2000; Pearson, 1995; Pearson and Christie, 1991; Reise and Gallardo, 1990; Yañez et al., 1987). While examples of both E. chinchilloides (e.g., FMNH 50600, 50601, 50736; USNM 482138-482140) and E. petersoni (e.g., FMNH 50583, 50584-50593, 50595-50599; USNM 84197, 84200, 84202) possess upper incisors with distinct mediolateral grooves, the series otherwise differ in size and color, abrupt contrasts over relatively short geographic distances that persuaded Osgood (1943) to maintain each as species. A strong size separation is actually conveyed in the morphometric analysis of Reise and Gallardo (1990:Fig. 3), which employed all variables and in which samples of chinchilloides proper are non-overlapping in multivariate space (Note that certain operational taxonomic units defined by those authors are undoubtedly species composites, a situation that affects measures of intra-sample covariation and compromises statistics of inter-sample dispersion). As implied by the range limits, we tentatively assign those northern samples that co-occur with E. mordax to E. petersoni, but, as noted by Pine et al. (1979), they do not convincingly fit with either E. chinchilloides or E. petersoni as known by populations in S Chile and Argentina. Until such problems and differences can be resolved in the context of a substantive generic revision, using larger samples and other kinds of data, we continue to follow Osgood (1943). Karyotype (2n = 36, FN = 66) reported by Reise and Gallardo (1990, as E. chinchilloides).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1115, DOI: 10.5281/zenodo.7316535
The PJI-TNM classification for periprosthetic joint infections
Creators: name: Baertl, Susanne
name: Rupp, Markus
name: Kerschbaum, Maximilian
name: Morgenstern, Mario
name: Baumann, Florian
name: Pfeifer, Christian
name: Worlicek, Michael
name: Popp, Daniel
name: Amanatullah, Derek F.
name: Alt, Volker
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Periprosthetic joint infection; Classification; PJI-TNM; Validation; Periprosthetic joint infections (PJIs); Morbidity; orthopaedic surgeons; Tissue implants; clinicians; infections; biofilm; comorbidities; Hip; Charlson Comorbidity Index (CCI)
subject: 610 Medizin

description: Aims

This study aimed to evaluate the clinical application of the PJI-TNM classification for periprosthetic joint infection (PJI) by determining intraobserver and interobserver reliability. To facilitate its use in clinical practice, an educational app was subsequently developed and evaluated.
Methods

A total of ten orthopaedic surgeons classified 20 cases of PJI based on the PJI-TNM classification. Subsequently, the classification was re-evaluated using the PJI-TNM app. Classification accuracy was calculated separately for each subcategory (reinfection, tissue and implant condition, non-human cells, and morbidity of the patient). Fleiss’ kappa and Cohen’s kappa were calculated for interobserver and intraobserver reliability, respectively.
Results

Overall, interobserver and intraobserver agreements were substantial across the 20 classified cases. Analyses for the variable ‘reinfection’ revealed an almost perfect interobserver and intraobserver agreement with a classification accuracy of 94.8%. The category 'tissue and implant conditions' showed moderate interobserver and substantial intraobserver reliability, while the classification accuracy was 70.8%. For 'non-human cells,' accuracy was 81.0% and interobserver agreement was moderate with an almost perfect intraobserver reliability. The classification accuracy of the variable 'morbidity of the patient' reached 73.5% with a moderate interobserver agreement, whereas the intraobserver agreement was substantial. The application of the app yielded comparable results across all subgroups.
Conclusion

The PJI-TNM classification system captures the heterogeneity of PJI and can be applied with substantial inter- and intraobserver reliability. The PJI-TNM educational app aims to facilitate application in clinical practice. A major limitation was the correct assessment of the implant situation. To eliminate this, a re-evaluation according to intraoperative findings is strongly recommended.
Exoprosopa heros Wiedemann 1819
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Exoprosopa
Exoprosopa heros

description: Exoprosopa heros (Wiedemann, 1819)
83. Exoprosopa (Exoprosopa) loewiana 1ɗ South Africa (Eastern Cape): Willowmore (H. Brauns). MS page [84].
Bezzi, 1921a: 156 – key and referral to a female specimen in Loew (1860: 234) in ZMHB.
Hesse, 1956: 822 – synonymised with heros.
Evenhuis & Greathead, 1999: 362 – listed an undetermined number of syntypes in ZMHB.
Types: The syntype in HNHM was destroyed in 1956. Bezzi’s (1921a) mention of a specimen referred to in Loew (1860) relates to a female from “Cap” collected by Tollin that is in ZMHB. It is described on p. 234 of Loew (1860) and the wing is illustrated on pl. 2, fig. 13. This appears to be the only known syntype. Brauns’s collection, now in NMSA, has 46 specimens of E. heros collected by Dr Brauns at Willowmore and localities in the Western Cape, Mpumalanga and North West Provinces. Two specimens are probably duplicate specimens of material sent to Bezzi: 1Ψ, Willowmore, 15.xi.1919 with orange “31 Bezzi” label; 1Ψ, Piet Retief, iii.1918 with orange “37 Bezzi” label. There is no indication that either of these were originally determined as E. loewiana.
Remarks: Hesse (1956) showed that E. loewiana falls within the range of variation of this common and variable southern African species.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 33, DOI: 10.5281/zenodo.158466
Addressing Genetic Tumor Heterogeneity, Post-Therapy Metastatic Spread, Cancer Repopulation, and Development of Acquired Tumor Cell Resistance
Creators: name: Harrer, Dennis Christoph
name: Lüke, Florian
name: Pukrop, Tobias
name: Ghibelli, Lina
name: Reichle, Albrecht
name: Heudobler, Daniel
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: tumor tissue editing; anakoinosis; M-CRAC; drug resistance; tumor heterogeneity; tumor cell repopulation; metastases; pioglitazone; drug repurposing; metronomic chemotherapy; transcriptional modulation
subject: 610 Medizin

description: The concept of post-therapy metastatic spread, cancer repopulation and acquired tumor
cell resistance (M-CRAC) rationalizes tumor progression because of tumor cell heterogeneity arising
from post-therapy genetic damage and subsequent tissue repair mechanisms. Therapeutic strategies
designed to specifically address M-CRAC involve tissue editing approaches, such as low-dose
metronomic chemotherapy and the use of transcriptional modulators with or without targeted
therapies. Notably, tumor tissue editing holds the potential to treat patients, who are refractory to or
relapsing (r/r) after conventional chemotherapy, which is usually based on administering a maximum
tolerable dose of a cytostatic drugs. Clinical trials enrolling patients with r/r malignancies, e.g.,
non-small cell lung cancer, Hodgkin’s lymphoma, Langerhans cell histiocytosis and acute myelocytic
leukemia, indicate that tissue editing approaches could yield tangible clinical benefit. In contrast to
conventional chemotherapy or state-of-the-art precision medicine, tissue editing employs a multipronged
approach targeting important drivers of M-CRAC across various tumor entities, thereby,
simultaneously engaging tumor cell differentiation, immunomodulation, and inflammation control.
In this review, we highlight the M-CRAC concept as a major factor in resistance to conventional
cancer therapies and discusses tissue editing as a potential treatment.
title: Civic architecture
title: Civic architecture
titleType: AlternativeTitle
title: Official building
titleType: AlternativeTitle
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Civic architecture
South Arabia
Pre-Islamic period
Public architecture
Official building

description: s.n. 2023. "Civic architecture". Thematic Dictionary of Ancient Arabia. Online edition 2023.
description: s.n. 2023. "Civic architecture". Thematic Dictionary of Ancient Arabia. Online edition 2023.
The French Aesthetics of Contingency
Creators: name: Lyons, John D.
Publisher: name: Spazio Filosofico
Year: 2014

description: This essay considers three important French literary authors who have made contingency (chance, fortune, randomness) a significant and explicit subject of their writings. Charles Baudelaire has become well known as a major poet of chance encounters within the large, crowded modern city of the second half of the nineteenth century. For him, chance—and the paradoxically related concept of artifice—offers a break with the ennui of nature and routine. His thought on these matters echoes (while also reversing the valorisation of many ideas) that of the seventeenth-century mathematician and Christian apologist Blaise Pascal, who also denounced nature, as human beings perceive it, as a “second nature,” one that conceals the first and that is dominated by chance. This “second” nature, alienated by original sin from divine reason, is permeated by randomness. However, within this random world, human beings cultivate certain forms of artificial chance (e.g., games of chance) as a way of escaping ennui. The last writer considered here is Stéphane Mallarmé, whose great modernist poem Un coup de dés jamais n’abolira le hasard (A throw of the dice will never abolish chance) raises chance from the level of everyday encounters to a heroic gesture associated with many of the pre-modern symbols of chance.
description: Spazio Filosofico, 12. Fortuna
Galenomys Thomas 1916
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Galenomys

description: Galenomys Thomas 1916
Galenomys Thomas 1916, Ann. Mag. Nat. Hist., ser. 8, 17: 143.
Type Species: Phyllotis garleppi Thomas 1898
Species and subspecies: 1 species:
Species Galenomys garleppi (Thomas 1898)
Discussion: Phyllotini. Named as a subgenus of Euneomys, later elevated to genus (Thomas, 1926 a), and reassociated as a subgenus of Phyllotis (Ellerman, 1941; Osgood, 1947; Corbet and Hill, 1991). Revised by Hershkovitz (1962), who considered Galenomys a distinct genus, as did Pearson (1958); phylogenetic evaluation of morphological characters depicts Galenomys as closely related to species of Ausliscomys (Braun, 1993; Steppan, 1995).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1116, DOI: 10.5281/zenodo.7316535
title: Rapport de voyage, D'Artagnan (1924) : Ligne de Chine et du Japon, 1929, n°5
Creators: name: Malaussena, Fortuné
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Compagnie des Messageries Maritimes
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapport du commandant
description: Source: French Lines & Compagnies, 1997 002 4018-11
description: Coverage: 1928-11-30/1929-03-01
Evidence-Based Approaches to Anticoagulation in Reconstructive Microsurgery—A Systematic Literature Review
Creators: name: Biermann, Niklas
name: Chak, Juy Chi
name: Wiesmeier, Anna
name: Klein, Silvan M.
name: Ruewe, Marc
name: Spoerl, Steffen
name: Kruppa, Philipp
name: Prantl, Lukas
name: Anker, Alexandra M.
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: systematic review; anticoagulants; microsurgery; free flaps; flap survival; replantation surgery; thrombosis prevention; aspirin; heparin; dalteparin
subject: 610 Medizin

description: This systematic review addresses the crucial role of anticoagulation in microsurgical procedures, focusing on free flap reconstruction and replantation surgeries. The objective was to balance the prevention of thrombotic complications commonly leading to flap failure, with the risk of increased bleeding complications associated with anticoagulant use. A meticulous PubMed literature search following Evidence-Based-Practice principles yielded 79 relevant articles, including both clinical and animal studies. The full-texts were carefully reviewed and evaluated by the modified Coleman methodology score. Clinical studies revealed diverse perioperative regimens, primarily based on aspirin, heparin, and dextran. Meta-analyses demonstrated similar flap loss rates with heparin or aspirin. High doses of dalteparin or heparin, however, correlated with higher flap loss rates than low dose administration. Use of dextran is not recommended due to severe systemic complications. In animal studies, systemic heparin administration showed predominantly favorable results, while topical application and intraluminal irrigation consistently exhibited significant benefits in flap survival. The insights from this conducted systematic review serve as a foundational pillar towards the establishment of evidence-based guidelines for anticoagulation in microsurgery. An average Coleman score of 55 (maximum 103), indicating low overall study quality, however, emphasizes the need for large multi-institutional, randomized-clinical trials as the next vital step.
Brain development from infancy to adulthood following very preterm birth
Creators: name: ARMSTRONG-KELLY, CLAIRE ELLEN
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 320999
subject: Neurosciences not elsewhere classified

description: Adverse experiences and events during the fetal and neonatal period, the most dynamic period of brain development, can profoundly influence lifelong health and well-being. This thesis investigated the consequences of being born very preterm on brain development from infancy to adulthood, through five studies involving brain imaging methods. It was found that very preterm birth impairs brain development over childhood, leading to long-lasting, amplified brain abnormalities years later, which are related to cognitive difficulties. The knowledge base generated will aid with future research and translational studies to support and improve developmental outcomes for all children.
Galenomys garleppi
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Galenomys
Galenomys garleppi

description: Galenomys garleppi (Thomas 1898)
[Phyllotis] garleppi Thomas 1898, Ann. Mag. Nat. Hist., ser. 7, 1: 279.
Type Locality: Bolivia, La Paz Dept., northeast of Mt Sajama, Esperanza, 4140 m.
Vernacular Names: Garlepp's Pericote.
Distribution: Altiplano, generally above 3000 m, of S Perú, N Chile, and adjacent Bolivia.
Conservation: IUCN – Lower Risk (lc).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1116, DOI: 10.5281/zenodo.7316535
Subtypes of Melanomas Associated with Different Degrees of Actinic Elastosis in Conventional Histology, Irrespective of Age and Body Site, Suggesting Chronic Ultraviolet Light Exposure as Driver for Lentigo Maligna Melanoma and Nodular Melanoma
Creators: name: Drexler, Konstantin
name: Zenderowski, Veronika
name: Schreieder, Laura
name: Koschitzki, Kevin
name: Karrer, Sigrid
name: Berneburg, Mark
name: Haferkamp, Sebastian
name: Niebel, Dennis
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: actinic elastosis; melanoma; nevogenesis; carcinogenesis; histopathology
subject: 610 Medizin

description: (1) Background: Ultraviolet (UV) radiation and sunburns are associated with an increased
incidence of acquired nevi and melanomas. However, the data are controversial as to whether chronic
UV exposure or high intermittent UV exposure is the major carcinogenic factor in melanocytic tumors.
In this study, we compared the degree of actinic elastosis (AE) as a surrogate for lifetime UV exposure
in nevi and different clinical melanoma subtypes (i.e., superficial spreading melanoma (SSM), nodular
malignant melanoma (NMM), acral lentiginous melanoma (ALM), and lentigo maligna melanoma
(LMM)) with respect to clinical variables (age, sex, and body site). (2) Methods: We defined a
semi-quantitative score for the degree of AE ranging from 0 = none to 3 = total loss of elastic fibers
(basophilic degeneration) and multiplied it by the perilesional vertical extent (depth), measured
histometrically (tumor-associated elastosis grade (TEG)).We matched the TEG of n = 595 melanocytic
lesions from 559 patients with their clinical variables. (3) Results: The TEG was correlated with age
and UV-exposed body sites. Furthermore, the TEG was significantly higher in LMM than in all other
types of melanomas and the TEG in NMM was higher than in SSM, irrespective of patient age and
tumor site. (4) Conclusions: High cumulative UV exposure is more strongly associated with LMM
and NMM than with other melanoma subtypes.
Fortuna, caso e giustizia distributiva
Creators: name: Panizza, Giulio
Publisher: name: Spazio Filosofico
Year: 2014

description: This essay examines the idea of luck in its possible relation with distributive justice. It then presents Dworkin’s distinction between “brute luck” and “option luck.” In light of Rawls’ A Theory of Justice and Williams’ notion of equality from a human point of view, the essay analyzes the notion of merit in its constitutive elements – “genetic lotteries,” “social capital,” historical and cultural context, and individual initiative – in order to bring out an unconventional configuration of the concept.
description: Spazio Filosofico, 12. Fortuna
Geoxus Thomas 1919
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Geoxus

description: Geoxus Thomas 1919
Geoxus Thomas 1919, Ann. Mag. Nat. Hist., ser. 9, 3: 207.
Type Species: Oxymycterus valdivianus Philippi 1858
Species and subspecies: 1 species:
Species Geoxus valdivianus (Philippi 1858)
Discussion: Akodontini (S Andean clade). Revised by Osgood (1925, 1943) as part of Notiomys —see remarks under Chelemys. Sister genus to Pearsonomys according to maximum parsimony and likelihood analyses of cytochrome b sequences (Smith and Patton, 1999).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1116, DOI: 10.5281/zenodo.7316535
Fortuna e azzardo ai tempi del capitalismo
Creators: name: Cuozzo, Gianluca
Publisher: name: Spazio Filosofico
Year: 2014

description: Of the ancient meanings of the Latin term “fortuna”, the only ones that still survive are those of “abundance” (that is, the so-called cornucopian worldview) and “chance” (that is, to take a chance, to gamble). Capitalism has oversimplified our attitude toward reality. At the same time, though, new myths have been entering the picture, mixing with the professed purity of our economic considerations. Between the illusion of abundance and the unbridled race after the last paradise on earth, nature, now reduced to a mere trace of its old splendor, has fallen into decay, and lies at the foot of our hyper-frantic consumerism.
description: Spazio Filosofico, 12. Fortuna
D6.2 NET-Fuels Communication, Dissemination, and Exploitation Plan V1.0
Creators: name: WRG
name: REACH Innovation
name: UNIBO
name: Fraunhofer UMSICHT
name: LEITAT
name: SUT
name: ITHAKA
name: WRG
Publisher: name: Zenodo
Year: 2023
Subjects: Dissemination
Exploitation
Communication
Horizon Europe
Grant Number: 101083780
Advanced Biofuels
Biochar
Bio-Electrochemical Methanation
Carbon Capture and Utilisation
Pyrolysis
Oxy-fuel Combustion
Thermo-Catalytic Reforming

description: This document describes the Communication, Dissemination and Exploitation strategies and plan to be carried out by the NET-Fuels project. D6.2 delivers the Communication, Dissemination and Exploitation (CD&E) preliminary strategy, in order to communicate the project results, raise the profile of the NET-Fuels process and secure project awareness among relevant peers, as well as to support commercial and policymaker interest.

A comprehensive Communication, Dissemination, and Exploitation (CD&E) plan is fundamental to ensuring maximum impact of the NET-Fuels project by supporting the outputs from the project (e.g.: deliverables and key-exploitable results (KERs). Identifying target audiences and creating tailored information to engage and share with these audiences will put the necessary steps and actions in place to facilitate the future (post-project) maturation of the technology to pre-commercial scale and, ultimately, to full commercial implementation.
description: For the purposes of this NET-Fuels Horizon Europe Project Deliverable at this early stage in the project, this document is a first draft of the intentions for CD&E and the anticipated routes that will be taken to maximise impact. This CD&E plan is a living document and will be updated and amended as new information and data is acquired, with further reports and planning updates on CD&E activities delivered:
▪ D6.2 - Dissemination, exploitation and communication plan (M6, April 2023)
▪ D6.3 - First dissemination, exploitation and communication report (M16, February 2024)
▪ D6.4 - Second dissemination, exploitation and communication report (M36, October 2025)
Geoxus valdivianus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Geoxus
Geoxus valdivianus

description: Geoxus valdivianus (Philippi 1858)
[Oxymycterus] valdivianus Philippi 1858, Arch. Naturgesch., 24 (1): 303.
Type Locality: Chile, Valdivia Prov.
Vernacular Names: Valdivian Long-clawed Akodont.
Synonyms: Geoxus araucanus (Osgood 1925); Geoxus bicolor (Osgood 1943); Geoxus bullocki (Osgood 1943); Geoxus chiloensis (Osgood 1925); Geoxus fossor Thomas 1919; Geoxus michaelseni (Matschie 1898); Geoxus microtis (J. A. Allen 1903).
Distribution: C and S Chile (see Saavedra and Simonetti, 2001, for northern range extension), including Mocha and Chiloe Isls, to Straits of Magellan, and S Argentina (Neuquén to Santa Cruz Provs.).
Conservation: IUCN – Lower Risk (lc).
Discussion: Pearson (1984) noted the uncertainty of the generic association and specific status of michaelseni, which has been arranged as a subspecies (Osgood, 1943; Patterson, 1992 b) or later listed as species (Reig, 1987). The taxon’s status and relationship clearly merit further study. Subspecific distributions in Chile sketched by Muñoz Pedreros (2000).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1116, DOI: 10.5281/zenodo.7316535
Graomys Thomas 1916
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Graomys

description: Graomys Thomas 1916
Graomys Thomas 1916, Ann. Mag. Nat. Hist., ser. 8, 17: 141.
Type Species: Mus griseoflavus Waterhouse 1837
Synonyms: Bothriomys Ameghino 1889.
Species and subspecies: 4 species:
Species Graomys centralis (Thomas 1902)
Species Graomys domorum (Thomas 1902)
Species Graomys edithae Thomas 1919
Species Graomys griseoflavus (Waterhouse 1837)
Discussion: Phyllotini. Doubtfully retained as a genus distinct from Phyllotis by Ellerman (1941), later included in Phyllotis as a formal subgeneric division (Osgood, 1947; Pearson, 1958) or not (Hershkovitz, 1962). Thomas (1919) remained firm regarding the generic distinctiveness of Phyllotis and Graomys, and the latter was so reinstated based on karyological data (Pearson and Patton, 1976) and other traits (see Olds and Anderson, 1989; Reig, 1978). Generic stature uniformly reinforced in broad phylogenetic studies of phyllotine taxa, using either morphological characters (Braun, 1993; Steppan, 1993, 1995) or molecular data (Anderson and Yates, 2000). Also see remarks under Andalgalomys, which Steppan (1995) included as a subjective synonym of Graomys.
Williams and Mares (1978) transferred Graomys pearsoni Myers, 1977, to Andalgalomys, and Massoia (1976) synonymized G. hypogaeus Cabrera, 1934, with Eligmodontia typus. Pardiñas (1995) identified the synonymy of Bothriomys with Graomys, contra Herskovitz (1962) who placed it under Euneomys (McKenna and Bell [1997] placed it under both Graomys and Euneomys), and recommended retention of Graomys as nomen protectum, it being the familiar and long used genus-group name for these phyllotine rodents.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1116, DOI: 10.5281/zenodo.7316535
Prehabilitation of dysphagia in the therapy of head and neck cancer- a systematic review of the literature and evidence evaluation
Creators: name: Vester, Sarah
name: Muhr, Anna
name: Meier, Johannes
name: Süß, Christoph
name: Kummer, Peter
name: Künzel, Julian
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: prehabilitation, dysphagia, aspiration, speech therapy, head and neck squamous cell carcinoma, flexible endoscopic evaluation of swallowing
subject: 610 Medizin

description: Background: Prehabilitation is becoming increasingly important in oncology because of the significant survival benefits that the reduction of malnutrition provide. Specifically, tumor- and therapy-related dysphagia leads to malnutrition in more than half of head and neck tumor patients. Studies describe the positive effects of an early onset of swallow-specific prehabilitation on the protection of the swallowing function. This paper intents to evaluate the existing evidence on the efficacy of preventive forms of swallowing therapy.

Methods: A systematic literature search was performed in February 2022 in the Cochrane Library, MEDLINE via PubMed, and ClinicalTrials.gov databases for randomized controlled trials investigating preventive swallowing therapy in head and neck tumor patients. This Procedure complies with the PRISMA statement. The RCTs were evaluated by using the PEDro Scale and the Cochrane Risk of Bias tool RoB2.

Results: Five randomized-controlled trials with 423 participants were identified. Four Studies showed moderate to high quality in the PEDro analysis, one showed less. The risk of bias was high in all studies because there was no possibility for blinding and there were high dropout rates. Heterogeneity in interventions, measurement instruments, measurement time points, and outcomes limits a general statement about which swallowing exercises are suitable for the prevention of dysphagia in head and neck tumor patients. Evidence is provided for short-term effects (≤24 months) on functional aspects of swallowing and quality of life. Overall, a decreasing adherence over time was observed in the intervention groups.

Discussion: Initial studies describe swallowing-specific prehabilitation programs in head and neck tumor patients as effective, at least in the short term, whereas long-term effects need to be further investigated. At the current time the evidence base for clear recommendations does not appear to be sufficiently high and studies share a high risk of bias. Further well-designed research, especially considering the conditions in the national health care system, is needed.
Serum omentin-1 is correlated with the severity of liver disease in patients with chronic hepatitis C
Creators: name: Peschel, Georg
name: Weigand, Kilian
name: Grimm, Jonathan
name: Müller, Martina
name: Buechler, Christa
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Direct acting antivirals; Hepatitis C; Liver cirrhosis; Adipokine
subject: 610 Medizin

description: Abstract
BACKGROUND
Patients with chronic hepatitis C virus (HCV) infection have increased serum
omentin-1. Omentin-1 is an anti-inflammatory adipokine, and higher levels may
be a direct effect of HCV infection. Successful elimination of HCV by direct acting
antivirals almost normalized circulating levels of various molecules with a role in
inflammation.
AIM
To evaluate the effect of HCV infection on serum omentin-1, serum omentin-1
levels of HCV patients were measured before therapy and at 12 wk after therapy
end. Associations of serum omentin-1 with parameters of inflammation and liver
function were explored at both time points. Serum omentin-1 levels of patients
with and without liver cirrhosis, which was defined by ultrasound or the fibrosis-
4 (FIB-4) score, were compared.
METHODS
Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay
in 84 chronic HCV patients before therapy and at 12 wk after therapy end where
sustained virological response 12 (SVR12) was achieved in all patients. Serum
omentin-1 of 14 non-infected controls was measured in parallel.
RESULTS
In patients with chronic HCV, serum omentin-1 levels were not related to viral
load or viral genotype. HCV patients with liver steatosis and HCV patients with
Peschel G et al. Omentin-1 of hepatitis C patients
WJH https://www.wjgnet.com 1316 December 27, 2023 Volume 15 Issue 12
diabetes had serum omentin-1 levels comparable to patients not suffering from these conditions. Serum omentin-1
levels at SVR12 were similar in comparison to pretreatment levels. In addition, serum levels did not differ between
HCV-infected patients and non-infected controls. Serum omentin-1 levels did not correlate with leukocyte count or
C-reactive protein. Positive correlations of serum omentin-1 with bilirubin and the model for end-stage liver
disease score (MELD) were detected before therapy and at SVR12 in the whole cohort. Bilirubin and the MELD
score also positively correlated with serum omentin-1 levels in the subgroup of patients with ultrasound diagnosed
liver cirrhosis before therapy. At SVR12, serum omentin-1 levels of patients with liver cirrhosis negatively
correlated with albumin. Before therapy start, patients with high FIB-4 scores had increased serum omentin-1 in
comparison to patients with a low score. Serum omentin-1 levels of patients with liver cirrhosis defined by
ultrasound were increased at baseline and at SVR12.
CONCLUSION
Present study showed that liver cirrhosis, but not HCV infection per se, is related to elevated serum omentin-1
levels.
Sorte estetica. Sulla (s)fortuna di un concetto
Creators: name: Bertinetto, Alessandro
Publisher: name: Spazio Filosofico
Year: 2014

description: The notion of “aesthetic luck” has not had the same luck – no pun intended – of concepts such as “moral luck” and “epistemic luck.” In the aesthetic field, there is no debate similar to the ones ongoing in moral philosophy and epistemology. Whereas, when poking around in the literature one can bump, often by chance, into some lean hint to the topic, nevertheless we are far from having an open discussion on the subject. Why is that? One of the reasons for this absence could be the sterility, the impracticability or the implausibility of the very notion of aesthetic luck.
In this essay, I will explore this issue. I begin by briefly examining the relation between art and luck (§2). Artistic luck is understood mostly in structural analogy with moral luck. Then (§3), I discuss the idea of aesthetic luck as a kind of constitutive luck. Finally (§4), I critically explore three, at first glance promising, cases of aesthetic luck: the aesthetic appreciation of damaged nature, the gratuity of the aesthetic experience, and the justification of aesthetic judgment.
description: Spazio Filosofico, 12. Fortuna
title: Activité du port de Saint-Malo – 1683 – Cadix
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: céréales
subject: produits de la mer
subject: produits combustibles
subject: produits manufacturés
subject: cuirs, peaux et laines
subject: alcool
subject: épices et condiments

description: Marchandises au départ de Saint-Malo : grains
description: Catégories de marchandises au départ de Saint-Malo : produits agroalimentaires ; céréales
description: Marchandises arrivées à Saint-Malo : sel ; huile ; savon ; laine ; vin
description: Catégories de marchandises arrivées à Saint-Malo : produits de la mer ; produits combustibles ; produits manufacturés ; cuirs, peaux et laines ; produits agroalimentaires ; alcool ; épices et condiments
description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1683 avec le port "cadix"
description: Coverage: Grand commerce
description: Bibliographic citation: MERCIER. Le Commerce de Saint-Malo (1683). DES : Histoire : Rennes, [s.d.] (Bibliothèque François-Lebrun - Rennes 2, MH 1001)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Exoprosopa restricta Bezzi 1924
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Exoprosopa
Exoprosopa restricta

description: Exoprosopa restricta Bezzi, 1924
86. Exoprosopa (Exoprosopa) restricta 1ɗ Tanzania: Shirati, v.1909 (Katona). MS page [86].
Bezzi, 1924: 280 – key only.
Evenhuis & Greathead, 1999: 376 – location of type material unknown. Types: The holotype in HNHM was destroyed in 1956 and no others are known.
Remarks: No specimens of this species have been found. Bezzi’s manuscript diagnosis merely describes it as ‘exceedingly similar to E. contorta and from the same locality but the wing pattern much narrower’ as is indicated in his key (Bezzi, 1924).
Description. The description in Bezzi’s manuscript is extremely brief:
“Length of body, 11.5 mm; of wing 13 mm.
Head, thorax, scutellum and abdomen all as in the preceding; sides of abdomen with a fringe of pale yellow hair; sides of mouth yellowish; proboscis distinctly shorter. Legs as preceding. Dark marking of wings much reduced, infuscation in first submarginal [r2+3] and first posterior [r5] cells restricted to the base; in discal cell restricted to the base, inner angle very sparingly infuscated; base of fourth posterior [cua1] cell completely hyaline, anal at base very little and axillary lobe also. Position of veins as in the preceding, but anterior transverse vein [r­m] before the middle and opposite the angle at the base of the discal cell on the posterior side, discal cell much constricted there.”
The description hardly distinguishes E. restricta from a large number of similar African species and must therefore be considered a nomen dubium for the time being.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on pages 34-35, DOI: 10.5281/zenodo.158466
Graomys centralis
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Graomys
Graomys centralis

description: Graomys centralis (Thomas 1902)
[Graomys] centralis (Thomas 1902), Ann. Mag. Nat. Hist., ser. 7, 9: 240.
Type Locality: Argentina, Córdoba Prov., Cruz del Eje, 600 m.
Vernacular Names: Central Pericote.
Distribution: C Argentina (La Rioja, Catamarca, and Córdoba Provs.); distributional limits uncertain.
Discussion: Described as a subspecies of griseoflavus and early recognized at that rank (Cabrera, 1961; Ellerman, 1941; Gyldenstolpe, 1932); later merged as a full synonym of Phyllotis g. griseoflavus by Hershkovitz (1962). Substantial divergence in allozymes, genomic content, and karyotypes, together with laboratory breeding results, collectively supports the specific status of populations referrable to centralis (Ramírez et al., 2001; Theiler and Blanco, 1996; Theiler and Gardenal, 1994; Theiler et al., 1999; Zambelli et al., 1994), as known from C Argentina. However, whether centralis will prove to be the oldest name to apply to the 2n = 42 karyomorph, versus 2n = 36-38 in G. griseoflavus, or whether other names should be added to its synonymy, will require broader analyses of populations of Graomys, especially those yet included within G. griseoflavus; see Tiranti (1998 a) for a thoughtful overview of the geographic ranges of different karyomorphs and the nomenclatural issues to be illuminated in order to apply the proper specific epithets.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1117, DOI: 10.5281/zenodo.7316535
"Questa inconstante dea": Machiavelli’s Amoral Fortuna
Creators: name: Benner, Erica
Publisher: name: Spazio Filosofico
Year: 2014

description: Machiavelli often portrays fortuna as an inconstant, amoral power that gives or takes benefits regardless of its beneficiaries’ or victims’ merits. Yet though fortune appears omnipotent, he also insists that human beings have a power of their own – virtú – that can reduce its impact. What is this virtú that can lessen the harms inflicted by fortuna? This, I’ll propose, is the real question posed by Machiavelli’s often deeply perplexing reflections on fortune. His main concerns are ethical: he is interested in how human beings react to the seemingly arbitrary advantages and disadvantages they call fortuna, and how they help to create their good or bad circumstances by their own good or bad choices.
description: Spazio Filosofico, 12. Fortuna