cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Construction sector views on low carbon building materials
Creators: name: Giesekam, Jannik
name: Barrett, John R.
name: Taylor, Peter
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: As is the case in a number of countries, the UK construction industry faces the challenge of expanding production whilst making ambitious greenhouse gas emission reductions. Embodied carbon constitutes a growing proportion of whole-life carbon emissions and accounts for a significant share of total UK emissions. A key mitigation strategy is increasing the use of alternative materials with lower embodied carbon. The economic, technical, practical and cultural barriers to the uptake of these alternatives are explored through a survey of construction professionals and interviews with industry leaders. Perceptions of high cost, ineffective allocation of responsibility, industry culture, and the poor availability of product and building-level carbon data and benchmarks constitute significant barriers. Opportunities to overcome these barriers include earlier engagement of professionals along the supply chain, effective use of whole-life costing, and changes to contract and tender documents. A mounting business case exists for addressing embodied carbon, but has yet to be effectively disseminated. In the meantime, the moral convictions of individual clients and practitioners have driven early progress. However, this research underscores the need for new regulatory drivers to complement changing attitudes if embodied carbon is to be established as a mainstream construction industry concern.
Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors
Creators: name: Friggeri, Laura
name: Vita, Daniela De
name: Pandolfi, Fabiana
name: Tortorella, Silvano
name: Costi, Roberta
name: Santo, Roberto Di
name: Scipione, Luigi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Cell Biology
Biochemistry
Biophysics

description: Metal ions, especially copper, zinc and iron, play an important role in the neurodegeneration process because they can affect protein misfolding, leading to the formation of the amyloid deposits and oxidative stress leading to reactive oxygen species (ROS). Here we report the synthesis and evaluation as antioxidant and metal chelating agents of 3,4-dihydroxybenzoic acid derivatives. Synthesized compounds were tested by the 2,2-diphenyl-2-picrylhydrazyl (DPPH) method showing a radical scavenging ability (EC50 = 0.093–0.118 μM) higher than Trolox used as reference. Furthermore, these compounds were able to bind both iron and copper, especially the iron (III), by the formation of hexa-coordinated complexes. Synthesized compounds were tested to evaluate their ability to inhibit acetyl- and butyryl-cholinesterase; the obtained results have demonstrated that they are selective inhibitors of AChE (Ki = 1.5–18.9 μM) and result weakly active versus butyrylcholinesterase (BChE).
New barbiturates and thiobarbiturates as potential enzyme inhibitors
Creators: name: Qureshi, Ashfaq M
name: Saira Mumtaz
name: Rauf, Abdul
name: Ashraf, Muhammad
name: Rumana Nasar
name: Chohan, Zahid H
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Microbiology
subject: Biochemistry

description: A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87–96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.
Investigation of major phenolic antioxidants from Camellia sinensis fruits
Creators: name: Rana, Ajay
name: Singh, Harsh Pratap
name: Ashu Gulati
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology

description: The present study unveils major phenolic antioxidant compounds from Camellia sinensis fruits, followed by their investigation, purification and characterization using HPLC, ESI-MS and NMR studies. The spectrophotometric estimation results have clearly demonstrated that C. sinensis (tea) fruits contain up to 14% of total polyphenols (as gallic acid equivalent) and 7% of flavonoids (as quercetin equivalent) on dry weight basis. Differential solvent-mediated extractions have been performed for quantitative assessment of major phytoconstituents by RP-HPLC analysis. And the results have revealed that these fruits contain adequate amount of tea catechins (4%) along with caffeine (1%) and theanine (0.4%) on dry weight basis. Moreover, purification and characterization of major phytoconstituents such as epigallocatechin, epicatechin, epigallocatechin gallate and epicatechin gallate along with caffeine have been accomplished. Thus, it is clearly demonstrated that tea fruits could act as a possible and reliable source for obtaining major phenolic antioxidants.
Novel phenolic inhibitors of the sarco/endoplasmic reticulum calcium ATPase: identification and characterization by quantitative structure–activity relationship modeling and virtual screening
Creators: name: Paula, Stefan
name: Hofmann, Emily
name: Burden, John
name: Stanton, David T.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Information and Computing Sciences
Biological Sciences
Chemistry
Pharmacology
Molecular Biology
Cell Biology
Biochemistry

description: Inhibitors of the sarco/endoplasmic reticulum calcium ATPase (SERCA) are valuable research tools and hold promise as a new generation of anti-prostate cancer agents. Based on previously determined potencies of phenolic SERCA inhibitors, we created quantitative structure–activity relationship (QSAR) models using three independent development strategies. The obtained QSAR models facilitated virtual screens of several commercial compound collections for novel inhibitors. Sixteen compounds were subsequently evaluated in SERCA activity inhibition assays and 11 showed detectable potencies in the micro- to millimolar range. The experimental results were then incorporated into a comprehensive master QSAR model, whose physical interpretation by partial least squares analysis revealed that properly positioned substituents at the central phenyl ring capable of forming hydrogen bonds and of undergoing hydrophobic interactions were prerequisites for effective SERCA inhibition. The established SAR was in good agreement with findings from previous structural studies, even though it was obtained independently using standard QSAR methodologies.
Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines
Creators: name: Lodarski, Krzysztof
name: Jończyk, Jakub
name: Guzior, Natalia
name: Bajda, Marek
name: Gładysz, Joanna
name: Walczyk, Joanna
name: Małgorzata Jeleń
name: Morak-Młodawska, Beata
name: Pluta, Krystian
name: Malawska, Barbara
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Pharmacology
Biochemistry

description: The study presents the discovery of novel butyrylcholinesterase (BuChE) inhibitors among derivatives of azaphenothiazines by application of in silico and in vitro screening methods. From an in-house library of compounds, 143 heterocyclic molecules derived from the azaphenothiazine scaffold were chosen for virtual screening. Based on results of the docking procedure, 15 compounds were identified as exhibiting the best fit for the two screening complexes (ligand – AChE and ligand – BuChE). Five compounds displayed moderate AChE and good BuChE inhibitory activity at screening concentrations of 10 µM. The IC50 values for active BuChE inhibitors were in the 11.8–122.2 nM range. Three of the most active inhibitors are tetra- or pentacyclic derivatives of azaphenothiazines with the same N-methyl-2-piperidinethyl substituent.
Femtosecond laser written waveguides with MoS2 as satuable absorber for passively Q-switched lasing
Creators: name: Cheng, Chen
name: Liu, Hongliang
name: Shang, Zhen
name: Nie, Weijie
name: Tan, Yang
name: Del Rosal Rabes, Blanca
name: de Aldana, Javier R. Vazquez
name: Jaque, Daniel
name: Chen, Feng
Publisher: name: Swinburne
Year: 2024

description: This work reports on the passively Q-switched waveguide laser system based on Nd:YAG crystal and MoS2 satuable absorber. A depressed cladding waveguide with circular cross-sectional geometry has been produced in Nd:YAG crystal by direct femtosecond laser writing at lowrepetition rate. The confocal microscopic investigation of the structure reveals the well-preserved microphotoluminescence features in the waveguide core. With chemical-vapor-deposition (CVD) MoS2 membrane as satuable absorber, the passive Q-switching of the Nd:YAG waveguide system has been achieved under optical pump, reaching maximum average output power of 85.2 mW, corresponding to single-pulse energy of 112 nJ, at wavelength of 1064 nm. The repetition rate of the pulsed waveguide laser system is tunable from 0.51 to 1.10 MHz, and the obtained minimum pulse duration is 203 ns.
Structure-based drug design and biological evaluation of 2-acetamidobenzothiazole derivative as EGFR kinase inhibitor
Creators: name: Gabr, Moustafa T.
name: El-Gohary, Nadia S.
name: El-Bendary, Eman R.
name: El-Kerdawy, Mohamed M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: EGFR tyrosine kinase has been reported mainly in 40–80% of non-small lung cancers, in addition to colon and breast cancers. In this study, we illustrate the synthesis of a highly potent antitumor agent. The synthesized compound 4 was screened at NCI, USA, for antitumor activity against non-small lung cancer, colon cancer and breast cancer cell lines. Results indicated that this compound is more potent antitumor agent compared to erlotinib against all tested cell lines except breast cancer (MDA-MB-468) cell line. In addition, it was tested initially at a single dose concentration of 100 µM over 11 different kinases. At this concentration, 94.45% inhibition of the enzymatic activity of EGFR kinase was observed, while the inhibition in activity was below 55% in all other kinases. Compound 4 was further tested in a 10-dose IC50 mode and showed IC50 value of 0.239 µM for EGFR kinase. In vivo acute toxicity of this compound was also tested.
A Comparison of Three Equation of State Compositional Simulators
Creators: name: Thele, Kent Joseph
Publisher: name: The University of Texas at Austin
Year: 1984
Subjects: Compositional simulation
Phase

description: During the past two decades, approximately one formulation per year has been published for compositional simulators. However, until now, no consistent comparison has been made on any of them. Three of these formulations were implemented on the Dual Cyber 170/750 machine and compared. Formulations by Nghiem, Fong, and Aziz (NFA) and Young and Stephenson (YS) were programmed for one and two dimensional problems, and the fully implicit formulation by Coats (C) was coded for one dimensional applications. These formulations were compared with respect to computer memory requirements, accuracy, and number of iterations and computation times required to satisfy carefully chosen convergence criteria. The phase behavior was modeled with the Peng-Robinson equation of state, and the flash calculations were performed using an accelerated successive substitution scheme by Mehra, Heidemann, and Aziz. From three to fifteen components were used in the test problems which consisted of multiple contact miscible and immiscible gas drives, a minimum miscibility pressure determination, and a carbon dioxide flood in a half of a five-spot pattern.
A novel design of bioartificial kidneys with improved cell performance and haemocompatibility
Creators: name: Oo, Zay
name: Kandasamy, Karthikeyan
name: Tasnim, Farah
name: Zink, Daniele
Publisher: name: Swinburne
Year: 2024

description: Treatment with bioartificial kidneys had beneficial effects in animal experiments and improved survival of critically ill patients with acute kidney injury in a Phase II clinical trial. However, a Phase II b clinical trial failed. This and other results suggested various problems with the current design of bioartificial kidneys. We propose a novel design to improve various properties of device, including haemocompatibility and cell performance. An important feature of the novel design is confinement of the blood to the lumina of the hollow fibre membranes. This avoids exposure of the blood to the non-haemocompatible outer surfaces of hollow fibre membranes, which usually occurs in bioartificial kidneys. We use these outer surfaces as substrate for cell growth. Our results show that commercial hollow fibre membranes can be directly applied in the bioreactor when human primary renal proximal tubular cells are grown in this configuration, and no coatings are required for the formation of robust and functional renal epithelia. Furthermore, we demonstrate that the bioreactor unit produces significant amounts of interleukins. This result helps to understand the immunomodulatory effects of bioartificial kidneys, which have been observed previously. The novel bioartificial kidney design outlined here and the results obtained would be expected to improve the safety and performance of bioartificial kidneys and to contribute to a better understanding of their effects.
An investigation of the social behaviour of archerfish Toxotes spp.
Creators: name: Der Weduwen, Dagmar Jacqueline
Publisher: name: The University of St Andrews
Year: 2024
Subjects: subject: Social learning
subject: Social behaviour
subject: Archerfish
subject: Public engagement
subject: Animal behaviour
subject: QL638.T6D4
subject: Archer fishes--Behavior
subject: Fishes--Behavior
subject: Social behavior in animals

description: Sociality has evolved multiple times in animals. Social living is a balance between the advantages and disadvantages of the increased presence of conspecifics. These costs and benefits are especially prevalent when foraging, as both the chance to discover resources and the rate at which they are depleted increase with group size. This holds true for archerfish Toxotes spp., a genus known for shooting down terrestrial prey using concentrated jets of water. This hunting method leaves the shooters open to theft, but whether and how their foraging behaviour and decision-making are affected by this threat is unclear. I investigated how group size affected aiming duration and shooting success, performed a pilot investigation into the use of video demonstrators for standardising social stimuli in such experiments, and tested whether archerfish socially learn target preferences when foraging in a group. I found evidence that archerfish decrease their aiming duration in the presence of more conspecifics. My results contradict previous research on kleptoparasitism in archerfish, mainly that the rate of kleptoparasitism is dependent on the behaviour of the shooter’s neighbours rather than group size. I also showed that archerfish avoid videos of conspecifics, although the explanation for this remains elusive. I attempted to find out whether archerfish can learn socially but instead found no evidence of learning. As scientists, we must study the natural world and share our findings with the public who fund our work. Accordingly, I created a tabletop role-playing style game based on archerfish ecology to test whether it could educate the public about my research and found that most participants improved their knowledge of archerfish. This thesis not only helps to further elucidate the social behaviour of archerfish but also illustrates how an animal’s ecology must be taken into consideration when conducting research and conveying the results to the public.
Cholinesterase inhibitory triterpenoids from the bark of Garcinia hombroniana
Creators: name: Jamila, Nargis
name: Melati Khairuddean
name: Khaw Kooi Yeong
name: Hasnah Osman
name: Vikneswaran Murugaiyah
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Biochemistry

description: Context: Garcinia hombroniana Pierre, known as manggis hutan in Malaysia is a rich source of xanthones and benzophenones.Objectives: This study was aimed to isolate and characterize potential cholinesterase inhibitors from the extracts of G. hombroniana bark and investigate their interactions with the enzymes.Materials and methods: The dichloromethane extract afforded five triterpenoids which were characterized by NMR and mass spectral techniques. Cholinesterase inhibitory assay and molecular docking were performed to get insight of the inhibitory activity and molecular interactions of the compounds. The compounds were also tested for their antioxidant capacity.Results: The isolated triterpenoids were identified as: 2β-hydroxy-3α-O-caffeoyltaraxar-14-en-28-oic acid (1), taraxerol (2), taraxerone (3), betulin (4) and betulinic acid (5). Compound 1 was the most active dual inhibitor of both AChE and BChE. Compound 1 also showed good antioxidant activities.Conclusion: Compound 1 had dual and moderate inhibitory activity on AChE and BChE worthy for further investigations.
The electronic supplement of the article "GENerator of reduced Organic Aerosol mechanism (GENOA v1.0): An automatic generation tool of semi-explicit mechanisms"
Creators: name: Wang, Zhizhao
name: Couvidat, Florian
name: Sartelet, Karine
Publisher: name: Zenodo
Year: 2022
Subjects: GENOA
SOA mechanism
air quality modeling

description: This package is part of the electronic supplement of the article "GENerator of reduced Organic Aerosol mechanism (GENOA v1.0): An automatic generation tool". The package contains three parts: 1. the source code of GENOA. 2. the input data required to run the GENOA reduction on the beta-caryophyllene (BCARY) mechanism from the Master Chemical Mechanism. 3. one reduction result example produced with the given input data and GENOA. Please read the manual (GENOA-BCARY-MCM/GENOA/GENOA_v1.0_Manual.pdf) for more information.
Developing design criteria for iPad stands to meet the needs of older adults in group settings
Creators: name: Renda, Gianni
name: Beh, Jeanie
name: Pedell, Sonja
name: Wright, Emily
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: This paper details the evaluation process undertaken to create criteria for the development of an iPad stand for elderly users. Emphasis is on the requirements elicitation stage with end users in the field. 32 elderly participants taking part in the activity group as part of the Ageing-Well program of a City Council in a cosmopolitan area in Australia were part of an evaluation in which three existing iPad stands were trialled. While commercially available stands are abundant, specific problems such as reduced grip, basic technical understanding of the stand, and concerns surrounding stability were encountered within the group. Observation and semi-structured interviews were undertaken with the cohort to determine factors surrounding the suitability and uptake of these stands by elderly users – most of them with some disabilities - with findings suggesting that current tablet stands require fine levels of dexterity, which may not be appropriate for elderly users where such a device is needed. While usability in setting up the stand and use is a strong factor, aesthetics and material qualities are equally important for enjoyable use. In addition, the use of iPads in social activities between two or more older adults has specific demands in terms of visibility of screen, sturdiness and easy movement that is not considered by current tablet stands. The paper ends with proposing design recommendations. Further research is required to develop a suitable solution and refines these
What Matters When We are in the Middle of Evolving Covid-19 Pandemic?
Creators: name: Woods, David D.
Publisher: name: Zenodo
Year: 2020
Subjects: Disaster resilience
Covid-19
pandemic
anticipation
risk of saturation

description: Ten points to cut through the noise, uncertainty and variety of communications as we are stakeholders and participants in reducing excessive deaths.
description: 16 minute talk version is is the opening part of the webinar from our Resilience Engineering Association Covid-19 series. https://zoom.us/rec/play/vsJ_ceCrrGk3SdCR5QSDVqUqW42_LK6s2iFPqPUNyE7hU3BWOgeuZOEaZrElUVKScU5YMLhunI0AzyZG?startTime=1585575948000
Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine
Creators: name: Plačková, Pavla
name: Hřebabecký, Hubert
name: Šála, Michal
name: Nencka, Radim
name: Tomáš Elbert
name: Mertlíková-Kaiserová, Helena
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Pharmacology
Cell Biology
Medicine
Biochemistry
Biophysics

description: 6-Chloropurines substituted at the position 9 with variously modified bicyclic skeletons represent promising antiviral and anticancer agents. This work aimed to investigate the transport mechanisms of 9-[(1R*,2R*,4S*)-bicyclo[2.2.1]hept-2-yl]-6-chloro-9H-purine (9-norbornyl-6-chloropurine, NCP) and their relationship to the metabolism and biological activity of the compound. Transport experiments were conducted in CCRF-CEM cells using radiolabeled compound ([3H]NCP). The pattern of the intracellular uptake of [3H]NCP in CCRF-CEM cells pointed to a combination of passive and facilitated diffusion as prevailing transport mechanisms. NCP intracellular metabolism was found to enhance its uptake by modifying NCP concentration gradient. The transport kinetics reached steady state under the conditions of MRP and MDR proteins blockade, indicating that NCP is a substrate for these efflux pumps. Their inhibition also increased the cytotoxicity of NCP. Our findings suggest that the novel nucleoside analog NCP has potential to become a new orally available antileukemic agent due to its rapid membrane permeation.
Design, synthesis, characterization and in vitro and in vivo anti-inflammatory evaluation of novel pyrazole-based chalcones
Creators: name: Chavan, Hemant V.
name: Laxman K. Adsul
name: Amol S. Kotmale
name: Valmik D. Dhakane
name: Vishnu N. Thakare
name: Babasaheb P. Bandgar
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Microbiology
subject: Biochemistry

description: A series of novel pyrazole-based chalcones have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxyphenyl)-1H-pyrazole (6). The structures of regioisomers 6 and 7 were determined by 2D 1H–1H COSY, 1H–13C HSQC and 1H–13C HMBC experiments. The newly synthesized compounds were tested for their inhibitory activity against COX-1 and COX-2 using an in vitro cyclooxygenase (COX) inhibition assay. Moreover, they were investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw edema model for acute inflammation and cotton pellet-induced granuloma model for chronic inflammation. All the synthesized compounds showed potential to demonstrate anti-inflammatory activities, of particular interest compounds 10i, 10e, 10f, and 10h were found to be potent anti-inflammatory agents.
Search strategies related to : Sensitivity and Specificity of Atherosclerotic Plaque Components in Carotid Arteries Detectable by CT, MRI, PET, and Sonography – Comparison with Histology: A Systematic Review and Meta-analysis
Creators: name: Pakizer, David
name: Sirimarco, Gaia
name: Elmers, Jolanda
name: Michel, Patrik
name: Školoudík, David
Publisher: name: Zenodo
Year: 2022
Subjects: search strategies
databases
systematic review
Embase
Medline
Central Cochrane Library
Web of Science
Google Scholar

description: Search strategies for :

Databases

Embase.com

Medline OVID ALL

Central - Cochrane Library Wiley

Web of Science – Core collection

Search engine

Google Scholar
Synthesis of Some Selectively N-Protected (1S,2S)-p-Nitrophenylserinol–Based Diamino-1,3-dioxanes and Tripodands
Creators: name: Nagy, Iulia
name: Moldovan, Oana
name: Popa, Flavia
name: Lameiras, Pedro
name: Morar, Cristina
name: Sacalis, Carmen
name: Darabantu, Mircea
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry

description: The unconventional methodology for the non-epimerizable cycloacetalization of optically active (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (p-nitrophenylserinol) (condensed H2SO4 96% as solvent and catalyst, i.e., sulfuric transacetalization) producing (2R,4S,5S) diamino-1,3-dioxanes was enlarged by the use of N-protected forms of 2,2-dimethoxyethylamine (DMEA, aminoacetaldehyde dimethylacetal). Conversely, N-protected derivatives of p-nitrophenylserinol were successfully cyclocondensed with DMEA in the same sulfuric conditions. N-Functionalization of DMEA upon treatment with trimesic acid trichloride and cyanuric chloride yielded the corresponding triple amide and melamine, respectively. Their adapted sulfuric transacetalization in triplicate in reaction with arylserinols (aryl: phenyl, p-nitrophenyl) afforded a new series of optically active tripodands.
Feasibility and acceptability of advance care planning in elderly Italian and Greek speaking patients as compared to English-speaking patients: An Australian cross-sectional study
Creators: name: Detering, Karen
name: Sutton, Elizabeth
name: Fraser, Scott
name: Wallis, Kasey
name: Silvester, William
name: Mawren, Daveena
name: Whiteside, Kathryn
Publisher: name: Swinburne
Year: 2024

description: Objectives: To assess the feasibility and acceptability of facilitated advance care planning (ACP) discussions in elderly Italian and Greek-speaking inpatients compared to English-speaking inpatients. Design, setting and participants: This crosssectional study with convenience sampling was conducted in Melbourne, Australia, and recruited hospital inpatients with medical decision-making capacity, aged 65 years or above, who spoke Greek (25 patients), Italian (24 patients) or English (63 patients). Intervention: Facilitated ACP was offered, aiming to assists patients to consider and discuss their goals, values, beliefs and future treatment wishes with their family and doctor; to help them consider how they would like healthcare decisions made in the future if they become unable to do this for themselves; and to complete advance care directives. Main outcome measures: The completion of ACP discussions, their duration, advance care directive completion and utilisation of interpreters. Results: Of 112 patients, 109 (97%) had at least one discussion, 63 (54%) completed advance care directives, either nominating a substitute decisionmaker, documenting their wishes or both, and 76 (68%) included family in discussions. The median duration of discussions for all patients was slightly more than 1 h, over two visits. There were no differences between the Greek-speaking and the Italianspeaking patients, or between the Non-English speaking and the English-speaking patients in any of these measures. Only 14 non-English speaking patients, (30%) utilised interpreters, but when utilised, patients were much more likely (p<0.005) to complete advance care directives. Conclusions:
Facilitated ACP in elderly Italian and Greek-speaking patients is feasible, acceptable and is similar to that for English-speaking patients.
Novel, Simple, and Efficient Synthesis of 3-(2-(5-(Benzylideneamino)-3-phenyl-1H-pyrazol-1-yl)thiazol-4-yl)-4-hydroxy-6-methyl-2H-pyran-2-one Derivatives via a One-Pot, Four-Component Condensation Reaction
Creators: name: Thirupaiah Bade
name: Rajeswar Rao Vedula
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biochemistry

description: The synthesis of 3-(2-(5-(benzylideneamino)-3-phenyl-1H-pyrazol-1-yl)thiazol-4-yl)-4-hydroxy-6-methyl-2H-pyran-2-one derivatives was achieved through a one-pot, four-component reaction involving condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, thiosemicarbazide, phenacylcyanaide, and various aryl aldehydes in dry alcohol and few drops of acetic acid under reflux condition. This four-component reaction has some advantages such as ease of handling, good yields, and easy workup. All structures of newly prepared compounds were confirmed by analytical and spectral data.
“An environment built to include rather than exclude me”: Creating inclusive environments for human well-being
Creators: name: Layton, Natasha
name: Steel, Emily J.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 3303
subject: Design
classificationCode: 3399
subject: Other built environment and design

description: Contemporary discourses which challenge the notion of health as the “absence of disease” are prompting changes in health policy and practice. People with disability have been influential in progressing our understanding of the impact of contextual factors in individual and population health, highlighting the impact of environmental factors on functioning and inclusion. The World Health Organization’s (WHO) more holistic definition of health as “wellbeing” is now applied in frameworks and legislation, and has long been understood in occupational therapy theory. In practice, however, occupational therapists and other professionals often address only local and individual environmental factors to promote wellbeing, within systems and societies that limit equity in population health and restrict inclusion in communities. This paper presents an in-depth analysis of the supports and accommodations identified by a cohort of individuals (n-100) living with disability. A range of environmental facilitators and barriers were identified in peoples’ experience of “inclusive community environs” and found to influence inclusion and wellbeing. The roles and responsibilities of individuals, professionals, and society to enact change in environments are discussed in light of these findings. Recommendations include a focus on the subjective experience of environments, and application of theory from human rights and inclusive economics to address the multiple dimensions and levels of environments in working towards inclusion and wellbeing.
Golden Rectangle Treemap
Creators: name: Lv, Liangfu
name: Fan, Shiliang
name: Huang, Maolin
name: Huang, Weidong
name: Yang, Guolan
Publisher: name: Swinburne
Year: 2024

description: Treemaps, a visualization method of representing hierarchical data sets, are becoming more and more popular for its efficient and compact displays. Several algorithms have been proposed to create more useful display by controlling the aspect ratios of the rectangles that make up a treemap. In this paper, we introduce a new treemap algorithm, generating layout in which the rectangles are easier to select and hierarchy information is easier to obtain. This algorithm generates rectangles which approximate golden rectangles. To prove the effectiveness of our algorithm, at the end of this paper several analyses on golden rectangle treemap have been done on disk file system.
title: How robust are landslide susceptibility estimates?
Creators: name: Ozturk, Ugur
name: Pittore, Massimiliano
name: Behling, Robert
name: Rößner, Sigrid
name: Andreani, Louis
name: Korup, Oliver
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 550 Geowissenschaften

description: Much of contemporary landslide research is concerned with predicting and mapping susceptibility to slope failure. Many studies rely on generalised linear models with environmental predictors that are trained with data collected from within and outside of the margins of mapped landslides. Whether and how the performance of these models depends on sample size, location, or time remains largely untested. We address this question by exploring the sensitivity of a multivariate logistic regression-one of the most widely used susceptibility models-to data sampled from different portions of landslides in two independent inventories (i.e. a historic and a multi-temporal) covering parts of the eastern rim of the Fergana Basin, Kyrgyzstan. We find that considering only areas on lower parts of landslides, and hence most likely their deposits, can improve the model performance by >10% over the reference case that uses the entire landslide areas, especially for landslides of intermediate size. Hence, using landslide toe areas may suffice for this particular model and come in useful where landslide scars are vague or hidden in this part of Central Asia. The model performance marginally varied after progressively updating and adding more landslides data through time. We conclude that landslide susceptibility estimates for the study area remain largely insensitive to changes in data over about a decade. Spatial or temporal stratified sampling contributes only minor variations to model performance. Our findings call for more extensive testing of the concept of dynamic susceptibility and its interpretation in data-driven models, especially within the broader framework of landslide risk assessment under environmental and land-use change.
description: Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1346
title: „Fake Science“ ― Wissenschaft und Universität in transnationalen Anti-Gender-Diskursen
Creators: name: Rothermel, Ann-Kathrin
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 300 Sozialwissenschaften

description: Über kaum ein Thema werden so hitzige Debatten geführt wie über Geschlechtsidentität. Das Wissen darum, dass Gender sozial konstruiert ist, wird von Anti-Gender Aktivist*innen häufig als ‚Gender-Ideologie‘ bezeichnet und ruft heftige Gegenreaktionen hervor. Dies gilt nicht nur in Deutschland – sondern länderübergreifend. Auffällig viele der transnationalen Anti- Gender Mobilisierungen der letzten 20 Jahre finden bezogen auf Bildungseinrichtungen statt. Dieser Beitrag widmet sich der besonderen Rolle der Universität und der Wissenschaft für transnationale Anti-Gender Diskurse. Anhand verschiedener Beispiele zeige ich auf, dass das Verhältnis zwischen Anti-Gender Bewegungen und Wissenschaft geprägt ist von widersprüchlichen Dynamiken, von Abgrenzung aber auch Imitation. In ihrem Zusammenspiel wirken beide Dynamiken mobilisierend und tragen zum Erstarken regressiver Rollenbilder und antidemokratischer rechter Bewegungen in der breiteren Gesellschaft bei. Der letzte Teil des Beitrags ruft daher zu mehr Selbstreflexion der wissenschaftlichen Praxis auf Grundlage feministischer und intersektionaler Ansätze auf.
description: Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe; 184
One-Pot Sequential Approach for the Construction of Highly Functionalized Triazolo[4,3-c]pyrimidine Library
Creators: name: Kalpesh Vilapara
name: Himanshu Butani
name: Gami, Sagar
name: Hasmukh Khunt
name: Naliapara, Yogesh
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Evolutionary Biology
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Novel [1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamides were synthesized via oxidative cyclization of hydrazono-1,6-dihydropyrimidine-5-carboxamide intermediates by the application of iodobenzenediacetate as a sole cyclizing agent. Here, we report a one-pot sequential strategy to generate the corresponding triazolopyrimidines by condensation of preprepared α-acylketene dithioacetals and arylamidines. Moreover, this process describes the application of presynthesized arylamidines, which omits the Suzuki–Miyaura cross-coupling reaction and hence provides metal-free organic synthesis in an atom- and step-economical fashion.
A Mild and Efficient Route to 3-Vinylchromones in Aqueous Micellar Media
Creators: name: Vikash Kumar
name: Chatterjee, Amrita
name: Mainak Banerjee
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: A simple, mild, and ecofriendly method has been developed for the synthesis of 3-vinylchromones from 4-oxo-4H-1-benzopyran-3-carboxaldehyde (3-formylchromone) by simple Knoevenagel condensation with various active methylene compounds (AMC) in aqueous micellar media in the presence of catalytic amounts of cetyl trimethylammonium bromide (CTAB) and 1,4-diazabicyclo[2.2.2]octane (DABCO). In the case of malonic acid as AMC, the reaction resulted in formation of only Doebner decarboxylated products under the standard reaction condition. It has been also observed that 3-formylchromone derivatives primarily undergo tandem Knoevenagel and Michael reactions in the presence of > 2 equiv. of ethyl acetoacetate to produce benzophenone derivatives, by opening of pyran ring, as the sole product in good yields.
Ability in daily activities after early supported discharge models of stroke rehabilitation
Creators: name: Taule, Tina
name: Strand, Liv Inger
name: Assmus, Jörg
name: Skouen, Jan Sture
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Physiology
subject: FOS: Biological sciences
subject: Medicine

description: More knowledge is needed about how different rehabilitation models in the municipality influence stroke survivors’ ability in activities of daily living (ADL). Objectives: To compare three models of outpatient rehabilitation; early supported discharge (ESD) in a day unit, ESD at home and traditional treatment in the municipality (control group), regarding change in ADL ability during the first three months after stroke. Methods: A group comparison study was designed within a randomized controlled trial. Included participants were tested with the Assessment of Motor and Process Skills (AMPS) at baseline and discharged directly home. Primary and secondary outcomes were the AMPS and the modified Rankin Scale (mRS). Results and conclusions: Included were 154 participants (57% men, median age 73 years), and 103 participants completed the study. There were no significant group differences in pre–post changed ADL ability measured by the AMPS. To find the best rehabilitation model to improve the quality of stroke survivors’ motor and process skills needs further research. Patients participating in the ESD rehabilitation models were, compared with traditional treatment, significantly associated with improved ADL ability measured by the mRS when controlling for confounding factors, indicating that patients with social needs and physical impairment after stroke may benefit from ESD rehabilitation models.
A Cell- and Tissue-Specific Weakness of the Protein Homeostasis System Underlies Brain Vulnerability to Protein Aggregation.
Creators: name: Kundra, Rishika
name: Dobson, Christopher M
name: Vendruscolo, Michele
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Neuroscience
Molecular physiology
Transcriptomics

description: The phenomenon of protein misfolding and aggregation is associated with a wide range of neurodegenerative conditions that cause progressive loss of function in specific regions of the human brain. To understand the causes of the selective cell and tissue vulnerability to the formation of these deposits, we analyzed the ability of different cell and tissue types to respond, in the absence of disease, to the presence of high levels of aggregation-prone proteins. By performing a transcriptional analysis, we found that the protein homeostasis system that regulates protein aggregation is weaker in neurons than in other cell types and in brain tissues than in other body tissues. These results suggest that the intrinsic level of regulation of protein aggregation in the healthy state is correlated with the selective vulnerability of cells and tissues to protein misfolding diseases.
Can agroforestry help the EU Achieve net zero in the Land Sector by 2040?
Creators: name: LAWSON, Gerry
name: KAY, Sonja
name: DEN HERDER, Michael
name: DE BOECK, Anna
name: BERTOMEU, Manuel
name: BURGESS, Paul J
name: DERANJA, Davor
Publisher: name: Zenodo
Year: 2024

description: Presentation to 7th Agroforestry Congress, Brno, Czech Republic, May 2024
Discovery of an intermolecular disulfide bond required for the thermostability of a heterodimeric protein from the thermophile Hydrogenobacter thermophilus
Creators: name: Arai, Hiroyuki
name: Ishii, Masaharu
name: Keug Tae Kim
name: Chiba, Yoko
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: Factors that increase protein thermostability are of considerable interest in both scientific and industrial fields. Disulfide bonds are one of such factors that increase thermostability, but are rarely found in intracellular proteins because of the reducing environment of the cytosol. Here, we report the first example of an intermolecular disulfide bond between heteromeric subunits of a novel-type phosphoserine phosphatase from a thermophilic bacterium Hydrogenobacter thermophilus, which contributes to the protein thermostability at the physiological temperature. Comparison of remaining soluble proteins between wild-type and cysteine-deleted mutant using SDS-PAGE revealed that the disulfide bond increases the thermostability of the whole protein by tightly connecting a subunit with low solubility to the partner with higher solubility. Furthermore, it was strongly suggested that the disulfide bond is formed and contributes to the stability in vivo. This finding will open new avenues for the design of proteins with increased thermostability.
JUMAP
Creators: name: Zou, Yun
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460304
subject: Computer vision
classificationCode: 461106
subject: Semi- and unsupervised learning

description: With the development of data collection and storage technologies, time series data has become increasingly prevalent in various scenarios. Time series data visualization, which intuitively depicts the dynamic changes in time series data through graphical representations, has become an important research direction in data science and information visualization. Existing static data visualization methods have limitations such as inconsistent projection results, and current time series data visualization methods, such as Joint t-SNE, suffer from high computational complexity. To address these issues, we propose Joint UMAP. We first introduce a Graphlet Frequency Distribution (GFD) to capture edge similarities in adjacent time frames and then integrate a new vector constraint into UMAP's loss function to preserve inherited structures in the data space, ensuring consistency in subsequent projections. Using both synthetic and real-world datasets, we demonstrate that Joint UMAP outperforms existing techniques in terms of Average Local Coherence Error (ALCE) and Cross-Entropy(CE). Joint UMAP eliminates the global dependency of projection results during optimization, making it more advantageous in dynamic scenarios where datasets change over time.
The Beacon Calculus: A formal method for the flexible and concise modelling of biological systems.
Creators: name: Boemo, Michael A
name: Cardelli, Luca
name: Nieduszynski, Conrad A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Biological systems are made up of components that change their actions (and interactions) over time and coordinate with other components nearby. Together with a large state space, the complexity of this behaviour can make it difficult to create concise mathematical models that can be easily extended or modified. This paper introduces the Beacon Calculus, a process algebra designed to simplify the task of modelling interacting biological components. Its breadth is demonstrated by creating models of DNA replication dynamics, the gene expression dynamics in response to DNA methylation damage, and a multisite phosphorylation switch. The flexibility of these models is shown by adapting the DNA replication model to further include two topics of interest from the literature: cooperative origin firing and replication fork barriers. The Beacon Calculus is supported with the open-source simulator bcs (https://github.com/MBoemo/bcs.git) to allow users to develop and simulate their own models.