cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Membrane resting and action potentials from single myelinated nerve fibers.
Creators: name: Woodbury, John Walter
Publisher: name: University of Utah
Year: 2012
Subjects: Nerve Chamber
Microelectrode

description: 1.The development of the capillary microelectrode has been reviewed and the possibility that this technique can be used to obtain simultaneous measurements of the membrane resting and action potentials from single myelinated nerve fibers in situ is brought forward. 2. The electrical properties of the CME are discussed with respect to the distortion of changes in potential which it introduces.  A suitable approximation is developed whereby this distortion can be corrected for mathematically. 3. The development of electronic equipment which performs the necessary operations on the action potential is described.  It is this new method of correction which makes the use of this technique practicable. 4. Data on membrane resting and action potentials, relative thresholds, strength-duration relations, recovery of excitability and conduction velocity are presented for A fibers of frog sciatic nerve. 5. The average values of 17 pairs of data on resting and action potentials, selected on the basis of certain well justified assumptions, are resting potential 56 mv and action potential 73 mv.  The average action potential is 30% greater than the average resting potential.  The largest action potential recorded was 170 mv with a resting potential of 65 mv.  The actual values are estimated as 60-70 nv for the resting potential and 100-120 mv for the action potential.  6. Two distinct action potential shapes, N and I, were distinguished and reasons given for believing that they were recorded in nodal and intermodal regions, respectively.  7. The relationship between rise time and conduction velocity established by previous workers has been confirmed.  8. The electronic correction of the action potential is shown to be valid by comparison with graphical reconstruction.  9. Records showing that conduction block occurs in a quantized manner are shown to be interpretable only in terms of the theory that conduction is salutatory in these nerves.  10.  The mathematical description of the upike potential developed by Rosenblueth et al. was applied with only moderate success to membranal action potentials.  11. Strength-duration curves obtained on 12 different fibers were nearly identical in shape. One of the points on the curve is in marked disagreement with excitation theory.  The time constant of excitation is 0.180 msec.   12. Excitabilitiy-time after recover curves were obtained in three instances.  The absolutely refractory periods were 2-3 msec. 13. The relationship between conduction velocity and threshold established by previous workers was confirmed.  14. Reasons for believing that the records obtained were actually made transmembranally are given. 15.  The future possibilities of further work along this line and ways of improving the present technique are discussed.
BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
Creators: name: Springer, Maya Z.
name: Poole, Logan P.
name: Drake, Lauren E.
name: Bock-Hughes, Althea
name: Boland, Michelle L
name: Smith, Alexandra G.
name: Hart, John
name: Chourasia, Aparajita H.
name: Liu, Ivan
name: Bozek, Grazyna
name: Macleod, Kay F
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: 60506 Virology
subject: Computational Biology

description: Mitophagy formed the basis of the original description of autophagy by Christian de Duve when he demonstrated that GCG (glucagon) induced macroautophagic/autophagic turnover of mitochondria in the liver. However, the molecular basis of liver-specific activation of mitophagy by GCG, or its significance for metabolic stress responses in the liver is not understood. Here we show that BNIP3 is required for GCG-induced mitophagy in the liver through interaction with processed LC3B; an interaction that is also necessary to localize LC3B out of the nucleus to cytosolic mitophagosomes in response to nutrient deprivation. Loss of BNIP3-dependent mitophagy caused excess mitochondria to accumulate in the liver, disrupting metabolic zonation within the liver parenchyma, with expansion of zone 1 metabolism at the expense of zone 3 metabolism. These results identify BNIP3 as a regulator of metabolic homeostasis in the liver through its effect on mitophagy and mitochondrial mass distribution.
Aria Terzetto à 11 in Discante & Basso : Trio de Zemire et Azor : "Helas mon Père, cessés de la pleurer"
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1771

description: Stimmen: 2 Soprane und Bass z.T. ohne Text + unvollst. Violine I auf 3 Systemen (piccolo partitione) ; 2 Soprane (Fadmé + Lisbé) (due soprani) ; Bass (Sander) ; Violine I (violino primo) ; Violine II (violino secondo) ; Violoncello oder Fagotte (violoncello ò fagotto) ; Bassinstrument (basso) ; Horn I (corno primo in Dis) ; Horn I (im Altschlüssel notiert) (corno primo in alto viola) ; Horn II (corno secondo) ; Horn II (im Altschlüssel notiert) (corno secondo in alto viola) ; Trompete I (clarino primo) ; Trompete II (clarino secondo)
description: [André-Ernest-Modeste Gretry] ; [Text von Jean-François Marmontel]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver
Creators: name: Springer, Maya Z.
name: Poole, Logan P.
name: Drake, Lauren E.
name: Bock-Hughes, Althea
name: Boland, Michelle L
name: Smith, Alexandra G.
name: Hart, John
name: Chourasia, Aparajita H.
name: Liu, Ivan
name: Bozek, Grazyna
name: Macleod, Kay F
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Inorganic Chemistry
subject: 60506 Virology
subject: Computational Biology

description: Mitophagy formed the basis of the original description of autophagy by Christian de Duve when he demonstrated that GCG (glucagon) induced macroautophagic/autophagic turnover of mitochondria in the liver. However, the molecular basis of liver-specific activation of mitophagy by GCG, or its significance for metabolic stress responses in the liver is not understood. Here we show that BNIP3 is required for GCG-induced mitophagy in the liver through interaction with processed LC3B; an interaction that is also necessary to localize LC3B out of the nucleus to cytosolic mitophagosomes in response to nutrient deprivation. Loss of BNIP3-dependent mitophagy caused excess mitochondria to accumulate in the liver, disrupting metabolic zonation within the liver parenchyma, with expansion of zone 1 metabolism at the expense of zone 3 metabolism. These results identify BNIP3 as a regulator of metabolic homeostasis in the liver through its effect on mitophagy and mitochondrial mass distribution. Abbreviations: ASS1, arginosuccinate synthetase; BNIP3, BCL2/adenovirus E1B interacting protein 3; CV, central vein; GCG – glucagon; GLUL, glutamate- ammonia ligase (glutamine synthetase); HCQ, hydroxychloroquine; LIR, LC3-interacting region; MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta; mtDNA:nucDNA, ratio of mitochondrial DNA to nuclear DNA; PV, periportal vein; TOMM20, translocase of outer mitochondrial membrane protein 20.
Impact of process parameters and sludge properties on electro-dewatering performance
Creators: name: Liu, Jiangyan
name: Wu, Jiandong
name: Zhou, Xingqiu
name: Liu, Changyuan
name: Wei, Yijun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In this paper, the semi-theoretical kinetics equations were proposed and the electro-dewatering experiments of sludge were conducted to analyze the kinetics laws of electro-dewatering under constant voltage and constant current. The results showed that the decline rate of moisture content remained stable under constant current, while the decline rate of moisture content kept decaying in the operating mode of constant voltage. No matter in what kind of operating mode, the change in decline rate of moisture content was consistent with that of filtrate flow rate, both of which were essentially dependent on the current. The follow-up electro-dewatering tests under constant voltage were carried out by using three different kinds of sludge to understand the mechanism of electro-dewatering. The results showed that the main parameters that controlled the electro-dewatering behavior were measured current, conductivity and zeta potential of sludge. When treated at 30 V, sludge C reached the lowest moisture content, owing to its higher conductivity and zeta potential. However, the poorer electro-osmotic effect of sludge C led to its higher average unit energy consumption. By comparison, an increase of applied voltage was more effective for electro-dewatering process of sludge C but at the expense of higher energy consumption, while sludge A and B were more inclined to improve the electro-dewatering effect by extending the dewatering time. Finally, the derived equations were demonstrated by the experiments, which could provide guidance for the practical applications.
Orcid De – Integration Von Orcid In Journal-Workflows
Creators: name: Vierkant, Paul
Publisher: name: Zenodo
Year: 2018
Subjects: ORCID
Open Researcher and Contributor ID
ORCID DE
Autorenidentifikation
Konsortium
OJS
Verlage

description: Die eindeutige Zuordnung von Autorinnen und Autoren zu den von ihnen geschaffenen Werken zählt zu den großen Herausforderungen des Publikationsmanagements in der Wissenschaft. Das seit Mai 2016 von der DFG geförderte Projekt ORCID DE nimmt sich dieser Herausforderung an und hat die deutschlandweite Förderung der Open Researcher and Contributor ID (ORCID), einer eindeutigen Kennung für Forscherinnen und Forscher, an Hochschulen und außeruniversitären Forschungseinrichtungen zum Ziel.

Als Projektpartner unterstützen die Deutsche Nationalbibliothek, das Helmholtz Open Science Koordinationsbüro am Deutschen GeoForschungsZentrum GFZ sowie die Universitätsbibliothek Bielefeld deutschlandweit wissenschaftliche Einrichtungen bei der Integration und Einführung von ORCID. In dem auf drei Jahre angelegten Projekt wurden bisher eine Dialogplattform (www.orcid-de.org) aufgebaut, zwei ORCID DE Workshops durchgeführt, ein datenschutzrechtliches Gutachten veröffentlicht und ein Prototyp des nationalen Claiming Service für die Bielefeld Academic Search Engine (BASE) erstellt. Darüber hinaus wurde im Rahmen des Projekts die Gründung eines Konsortiums für die deutschen ORCID-Mitglieder initiiert und weiter begleitet.

Der Vortrag berichtet über ORCID sowie das Projekt ORCID DE und stellt die unterschiedlichen Schritte der Integration von ORCID in Journal Workflows u.a. von OJS vor.
Polystyrene Sulfonic Acid Promoted Synthesis of 14-Aryl-14H-dibenzo[a,j]xanthenes
Creators: name: Mirjalili, Bi Bi Fatemeh
name: Zaghaghi, Zahra
name: Monfared, Azam
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Polystyrene Sulfonic Acid Promoted Synthesis of 14-Aryl-14H-dibenzo[a,j]xanthenes
In vivo 4-hydroxylation of amphetamine in the rat
Creators: name: Law, Michael Yiu Lun
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolism
Hydrosylation

description: The predominant pathway for amphetamine metabolism in the rat is 4-hydroxylation. Limited in vitro data on the inhibition of debrisoquine hydroxylation by amphetamine suggest cytochrome P-450 (P450) 2D1 has a role in this reaction. In a preliminary experiment in which Lewis rats were pretreated with the P450 2D inhibitor, quinidine, reduced excretion of 4'-hydroxyamphetamine in the urine was found. As amphetamine and its metabolites are primarily excreted in the urine, measurement of urinary 4'-hydroxyamphetamine and amphetamine is a reasonable approach to study amphetamine's in vivo metabolism. An HPLC-UV method was developed in order to quantify 4'-hydroxyamphetamine and amphetamine in rat urine samples. In the initial study using P450 2D1-deficient Dark Agouti (DA) rats, a decrease in the excretion of 4'-hydroxyamphetamine (expressed as percentage of administrated dose) was found in the DA male (7.1 ± 2.3) and DA female (10.0 ± 2.8), as compared to the Sprague Dawley (SD) male (67.9 ± 6.3) and SD female (53.0 ± 8.3) rats. P450 2D's involvement in amphetamine 4'-hydroxylation was also established by enzyme induction and inhibition studies in SD rats. In vivo induction of P450s by 3-methylcholanthrene, phenobarbital, isosafrole, ethanol, pregnenolone-16/alpha-carbonitrile, clofibrate, and di-(2-ethylhexyl) phthalate produced minimal, if any, increase in the urinary excretion of 4'-hydroxyamphetamine. However, in vivo inhibition of P450s resulted in reduced excretion of 4'-hydroxyamphetamine (expressed as percentage of controls) in SD male rats pretreated with: 1-aminobenzotriazole, 7.2 ± 2.2; quinidine, 17.3 ± 1.6; quinine, 30.1 ± 5.9; and primaquine, 17.6 ± 7.4%. Neither diallyl sulfide, a P450 2E inhibitor, nor troleandomycin, a P450 3A inhibitor, reduced 4'-hydroxyamphetamine excretion (81.9 ± 13.4 and 76.4 ± 16.2% of control, respectively). The reduction in the urinary excretion of 4'-hydroxyamphetamine in the rats correlated positively p = 0.80) with decreases in a microsomal P450 2D1-dependent monooxygenase activity in rats which received the same inhibition treatments. This correlation, together with the findings of decreased 4-hydroxylation of amphetamine in female DA rats and in rats where P450 2D1-dependent monooxygenase activities have been inhibited, has now provided 2 independent lines of evidence to link P450 2D to amphetamine 4-hydroxylation.
Aria Terzetto à 11 in Discante de Zemire et Azor : "Veillons mes Soeurs, veillons encore la Nuit"
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1771

description: Stimmen: 3 Soprane ohne Text + unvollst. Violine I/Flöte/Oboe I auf 4 Systemen (picolo partitione) ; Sopran I [Fadmé] (soprano primo) ; Sopran II [Zémire] (soprano secondo) ; Sopran III [Lisbé] (soprano terzo) ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (alto viola) ; Bassinstrument (basso) ; Oboe I (oboe primo) ; Oboe II (oboe secondo) ; Horn I (corno primo in C) + Horn II (im Altschlüssel notiert) (corno secondo in alto viola) ; Horn II (corno secondo in C) + Horn I (im Altschlüssel notiert) (corno primo in alto viola)
description: Del Signore [André-Ernest-Modeste Gretry] ; [Text von Jean-François Marmontel]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
Evaluation of soil enzyme activities and microbial communities in tomato continuous cropping soil treated with jerusalem artichoke residues
Creators: name: Shiwen, Wang
name: Jing, Ren
name: Ting, Huang
name: Guanru, Qiao
name: haihui, Hu
name: Wenhui, Li
name: Wu, Fengzhi
name: Kai, Pan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Jerusalem artichoke (JY) (Helianthus tuberosus L.) has been reported to have a strong inhibitory effect on weed growth and root knot nematodes, but little information is available on the effects on soil ecosystems, especially soil microorganisms and soil enzyme activities. Understanding the dynamics of soil microbes and soil enzyme activities in cropping systems can help determine how agricultural practices influence soil processes mediated by JY residues. This study used a pot experiment, with five-year continuous cropping soil of tomato plants as the experimental material and 2% (w/w) JY residue as the treatment material in the soil. The treatment was compared to continuously monocropped tomato soil that was not treated with JY residues. The results of 16S high-throughput sequencing showed that both fungal and bacterial community structure and composition varied significantly at each stage of JY treatment. The analysis showed that the major phyla in the soil fungal community included Ascomycota, Zygomycota and Basidiomycota. Chytridiomycota was dominant in only the JY-treated soil. At the genus level, the abundances of Mortierella, Cephaliophora, Cryptococcus and Fusarium notably changed at each stage of JY treatment. In the bacterial community in the JY-treated group, the abundance of Proteobacteria increased significantly, while that of Firmicutes decreased significantly, compared to the control group. JY enhanced the activity of soil sucrase and urease. In addition, the soil sucrase activity showed a strong negative correlation with Fusarium and Bacillus. Overall, our results revealed that JY residues changed both the soil bacterial and fungal community composition and the soil enzyme activities.
Study of bacterial activity and ecology of Bingham Canyon mine dumps
Creators: name: Chen, Young-Chang
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Utah
subject: Microbiology
subject: FOS: Biological sciences
subject: Mining

description: There were at least two types of chemoautotrophic thiobacilli found in the leaching streams of Bingham Canyon min dump.  One of these organisms oxidizes free sulfur to sulfuric acid which reaction is its energy reaction.  This organism is very similar to Thiobacillus thiooxidans.  The other organism oxidizes ferrous to ferric ion as its initial energy reaction and is similar to thiobacillus ferrooxidans.  These two bacterial strains complement each other in that T. thiooxidans produces acid which keeps the ferric ion produced by T. ferrooxidans in solution, thereby forming an effective acidic ferric sulfate leaching solution for copper minerals.  In addition to these two types of chemoautotrophs, a yeast-like organism was found in every location of the Bingham mine dump waters.  The cell biology and physiology of these yeast-type organisms were studied.  It was found not to be a chemoautotrophic, but an acidophilic heterotroph.  The microbial population in the mine water samples suggests the coexistence of a balanced ecological system in which carbon fixation is dependent on chemoautotrophic bacteria.  Acidophilic heterotrophs, utilizing organic matter as their energy and carbon source, are acting to keep the organic content of leach waters at a low concentration favorable to the development of chemoautotrophs.  Three different counting techniques, such as a Petroff-Hausser counting technique, the silica gel plate counting technique and the radioisotope labeling technique for the enumeration of the chemoautotrophic thiobacilli were studies.  Of these methods, the direct microscopic counts were the only ones found to be satisfactory as the most rapid and relatively reliable method of estimating this type of cell numbers.  Statistical evaluation of Petroff-Hausser counting technique was also made to prove the reliability of this method.  The correlation between the conversion of ferrous to ferric ion and bacterial growth were studies.  It was shown that a given amount of conversion of ferrous to ferric ion over a given time period corresponded to a given increase in the bacterial population.  The distribution of Thiobacillus ferrooxidans and their ecological environment in the Bingham mine dump were investigated.  It was noted that there was a relationship between the numbers of T. ferrooxidans  in leaching systems and the chemical reactions which were known to occur in this process.
Aria Duetto à 5 (in Discante) : Del'Operette de la Nouvelle Rosiere de Salancy : "La plus Douce Esperence"
Creators: name: Grétry, André-Ernest-Modeste
name: Pezay, Alexandre Frédéric Jacques de Masson de
Publisher: name: [s.n.]
Year: 1773

description: Stimmen: Sopran (Cecile) + Tenor (Colin) + Bassinstrument + unvollst. Violine I auf 3 Systemen (partitione p. secondar la vocce) ; Sopran (Cecile) ; Tenor (Colin) ; Violine I (violine primo) ; Violine II (violino secondo) ; Bassinstrument (basso) ; Umschlag
description: Del Signore Grety ; [Text von Masson de Pezay]
description: Aus "La Rosiére de Salancy", Akt 1, Szene 4
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire April 2021 HAN-Katalogisierungsregeln jpl
Identification of behavioral risk factors for medically unsupervised use of prescription medications in Utah
Creators: name: Kitchens, Connie L
Publisher: name: University of Utah
Year: 2012
Subjects: Nonmedical prescription drug use
Risk factors
Medication abuse

description: Prescription drug misuse has become a widespread problem in the United States. Misuse of prescription drugs is second only to marijuana as the nation's most prevalent drug problem. National data shows that in 2002-2003 through 2005-2006, Utah ranked among those states with the highest rates of the past year nonmedical use of pain relievers among those age 12 and older. Using data from the 2008 Utah Behavioral Risk Factor Surveillance System (N=5,330) and the 2007 Utah Higher Education Health Behavior Survey (N=8,834), we completed three studies exploring nonmedical prescription drug use among the Utah adult  opulation. There were three different outcomes: medically unsupervised use of prescription pain medication; obtaining prescription drugs for nonmedical purposes; and using prescription drugs to manage pain. The last two outcomes were within the population of Utah college students.
Canadian Gallup Poll # 499-2
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Federal election vote intent(1); past federal elections vote(1); business conditions in the community(2); US capital in Canada(2); Prime Minister and the opposition leader job performances(3); job performance in public services(8); racial problems in Canada(3); possession of marijuana(1); people's beliefs(5); greatest threat to Canada: big business, labor or government(1); racial policies in South Africa(2). Note: Demographics(17).
Aria & Duetto à 10 (in Discante) : Ari de l'Operette de La nouvelle Rosiére de Salancy : "J'ay tout perdû! mon Amant et la Rose"
Creators: name: Grétry, André-Ernest-Modeste
name: Pezay, Alexandre Frédéric Jacques de Masson de
Publisher: name: [s.n.]
Year: 1773

description: Stimmen: Sopran (Cecile) + Tenor (Colin) + unvollst. Bassinstrument ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (alto viola) ; Bassinstrument (basso) ; Kontrabass (contra basso) (nur Szene 2) ; Oboe I (oboe primo) + Oboe II (oboe secondo) ; Horn I (corno primo) + Horn II (corno secondo)
description: Del Signore Gretry ; [Text von Masson de Pezay]
description: Aus "La Rosiére de Salancy", Akt 3, Szene 2 + 3
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire März 2021 HAN-Katalogisierungsregeln jpl
A comparison of the cyclone and the horizontal elutriator for sampling respirable dust in a Utah coal mine.
Creators: name: Taylor, John Michael
Publisher: name: University of Utah
Year: 2012
Subjects: Dust Control
Mine Safety

description: A field investigation was conducted comparing proposed optimizing parameters for estimating respirable dust according to British Medical Research Council (BMRC) criteria using a Dorr-Oliver 10 mn cyclone and the parameters presently applied under federal law.  Side-by-side samples were collected in an underground Utah coal mine with 10 mn cyclones at 1.2, 1.4, 1.7, and 2.0 liters per minute (lpm) and an MRE horizontal elutriator.  The cyclone concentrations were statistically compared to the elutriator concentrations.  Random errors were too large to conclusively confirm or disprove the cyclone optimization theory.  The data demonstrated trends which are more supportive of the 1.2 lpm, k=0.91 optimizing criteria than the 2.0 1pm, k=1.38 criteria outlined under the Federal Coal Mine Health and Safety Act.  The results of this study will be useful in planning more in-depth future research.
Selective inhibition of central sympathetic neurons by morphine and its reversal by naloxone.
Creators: name: McCloskey, Kevin Lee
Publisher: name: University of Utah
Year: 2012
Subjects: Neurons
Drug Effects

description: Recent investigations clarifying the monoaminergic influences on sympathetic preganglionic neurons in the cat have allowed a direct assessment of the effects of narcotic analgesics and antagonists on central transmission.  Intravenous morphine, methadone, meperidine or codeine produced an immediate and sustained depression of discharges evoked from these spinal sympathetic neurons.  The potency rations for production of similar degrees of depression by these four agents compared favorably to the potency ratios reported for equianalgesic doses.  The depression appeared to be specific in that it was rapidly reversed by very low doses of naloxone or nalorphine and that a non-analgesic stereoisomer related to these drugs produced qualitatively different effects on the sympathetic preganglionic neurons. The depression of these neurons offers an adequate and sufficient mechanism to account for the centrally mediated vasodepressor effect produced by morphine and other narcotic analgesics.  The pharmacological characterization of the morphine and naloxone actions strongly suggests that morphine functions as a 5-HT agonist in this system, while naloxone can both block 5-HT receptors and also stimulate these spinal neurons.  The significance of these findings relative to other acute and chronic effects of the narcotic analgesics are discussed.
62 Briefe, 6 Umschläge an [Johann Conrad] Nüscheler
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1785

description: von [Johann Caspar] Lavater
description: Darlehens- und Unterstützungsgesuche
description: Davon 1 Brief undatiert (Nr. 49)
description: Dabei 1 Briefzettel mit zwei Briefentwürfen Nüschelers an Lavater, dat. 28.1.1792 und 12.1.1793 (Nr. 18)
description: In vielen Fällen Notiz von Nüschelers Hand über Leihe, Rückzahlung oder Abschreibung der Beträge auf der Rückseite der Briefe
description: Nüscheler: im Neuegg, Assessor, Ratsherr, Kirchenpfleger
20 Briefe, 1 Umschlag an [Hans] Rudolf Ott
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1779

description: von Johann Caspar Lavater
description: Davon 1 Brief undatiert (Nr. 1)
description: Davon 8 Briefe an das Ehepaar Hans Rudolf und Sara Ott-Kilchsperger (1755-1834) gerichtet (Nr. 5, 9-13, 18 und 19)
description: Davon 1 Brief auf der Rückseite eines gedruckten Gedichtes "Auf Weyhnacht 1783" geschrieben (Nr. 18)
description: Davon 1 Brief an Anna Barbara Ott, später verh. Hirzel (1774-1858) gerichtet, dat. Richterswil, 6.9.1792 (Nr. 20)
description: Ott: 1751-1823, Salzamtsdirektor
Performance of biochar derived from Cymbopogon winterianus waste at two temperatures on soil properties and growth of Bacopa monneri
Creators: name: Yadav, Vineet
name: Khare, Puja
name: Deshmukh, Y.
name: Shanker, Karuna
name: Nigam, Nidhi
name: Karak, Tanmoy
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology

description: The present study aimed to evaluate the effect of biochar derived from the distilled waste of Cymbopogon winterianus at two different pyrolysis temperatures (450°C and 850°C) on the chemical and biological properties of sandy loamy soil (SLS) and its subsequent impact on plant growth. Pot experiments utilizing Bacopa monnieri were performed in a greenhouse with four different application rates of biochar (2%, 4%, 6%, and 8% (w/w)) for 120 days. Biochar induced alterations in soil properties (nutrients, enzymes, and microbes) and plant responses (yield, biocide and antioxidant content) to biochar addition were measured. Biochar application, notably improved the soil carbon, cation exchange capacity, and the availability of NH4 + and phosphorus. Initially, biochar produced at the lower temperature had more effect on the available nitrogen, phosphorus, soil enzymatic properties, and plant biomass growth. After 120 days, the pyrolysis temperature had only a marginal influence on biochar-induced effects on soil pH, WHC, and soil enzymatic activities. Our results suggest that C. winterianus derived biochar amendment leads to an overall amelioration of soil fertility and plant growth improvement. In specific biochar produced at lower temperatures (450°C) was more effective for improvement of plant biomass and soil characteristics.
Inference of breakpoints in high-dimensional time series
Creators: name: Chen, Likai
name: Wang, Weining
name: Wu, Wei Biao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: For multiple change-points detection of high-dimensional time series, we provide asymptotic theory concerning the consistency and the asymptotic distribution of the breakpoint statistics and estimated break sizes. The theory backs up a simple two-step procedure for detecting and estimating multiple change-points. The proposed two-step procedure involves the maximum of a MOSUM (moving sum) type statistics in the first step and a CUSUM (cumulative sum) refinement step on an aggregated time series in the second step. Thus, for a fixed time-point, we can capture both the biggest break across different coordinates and aggregating simultaneous breaks over multiple coordinates. Extending the existing high-dimensional Gaussian approximation theorem to dependent data with jumps, the theory allows us to characterize the size and power of our multiple change-point test asymptotically. Moreover, we can make inferences on the breakpoints estimates when the break sizes are small. Our theoretical setup incorporates both weak temporal and strong or weak cross-sectional dependence and is suitable for heavy-tailed innovations. A robust long-run covariance matrix estimation is proposed, which can be of independent interest. An application on detecting structural changes of the U.S. unemployment rate is considered to illustrate the usefulness of our method.
How undergraduate students of color experience multicultural education
Creators: name: Lee, Jinna
Publisher: name: University of Utah
Year: 2012
Subjects: Education
Higher
Minorities
Multicultural
Qualitative

description: One of the stated purposes of multicultural and diversity classes is to provide students of color with positive educational experiences. Little is known, however, about  how students of color experience multicultural education, particularly in the undergraduate diversity classes that are increasingly prevalent on college campuses. Using constructivist grounded theory and critical race theory, this study examined multicultural education as experienced by undergraduate students of color. Specifically, this study investigated what characterized positive and negative experiences in multicultural classes and how students of color felt about multicultural education through interviews, a focus group, and an online survey with 17 undergraduate students of color.  Many themes emerged, including the importance placed by students of color on discussions about racial inequality and the role of the professor in creating a safe  environment in which students felt their personal experiences and knowledge were valued. Students of color discussed both the harmful consequences of negative experiences of multicultural education and the potential for positive multicultural education experiences to uplift and transform. Students, despite criticisms of the ways in which multicultural education is currently implemented, voiced overwhelming support for the inclusion of multicultural and diversity classes in the curriculum. Included in the discussion are limitations of the study and implications for future research, practice,  policy, and social justice.
The protein network of HIV-1 budding
Creators: name: Brereton, Melissa Diane Stuchell
Publisher: name: University of Utah
Year: 2012
Subjects: HIV-1
Human ESCRT pathway
Virus budding
Protein network:

description: HIV-1 is an enveloped RNA virus that recruits cellular machinery to facilitate virus budding. HIV-1 Gag, the structural protein that drives the assembly and budding  processes, binds directly to two cellular factors, TSG101 and ALIX. Both TSG101 and ALIX are proteins in the endosomal sorting complexes required for transport (ESCRT) pathway and are required for inward vesicle formation at late endosomes or multivesicular bodies (MVBs). Most ESCRT proteins are subunits one of five heterooligomeric complexes named ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III, and the VPS4 AAA ATPases (vacuolar protein sorting), which are sequentially recruited to sites of vesicle formation and virus budding. TSG101 is a member of the ESCRT-I complex and  is involved in recognition of cargos and recruitment of ESCRT-II. ESCRT-II recruits ESCRT-III, which is composed of charged multivesicular body proteins (CHMPs) that coassemble to form a lattice on the surface of endosomal membranes. ALIX interacts with proteins in both ESCRT-I and ESCRT-III, but is not a constitutive member of either complex. ESCRT-III proteins bind directly to the VPS4 AAA ATPases, which are the only known enzymes in the pathway. ATP hydrolysis by the VPS4 ATPases releases all assembled ESCRT machinery, allowing multiple rounds of vesicle formation or viral egress. This thesis focuses on the identification and characterization of components of the human ESCRT protein network involved in HIV-1 budding.
Investigation of polynuclear aromatic hydrocarbons at a tar sands extraction facility
Creators: name: Geraci, Marie Celeste
Publisher: name: University of Utah
Year: 2012
Subjects: Hydrocarbons, physiological effect
Hydrocarbons, analysis

description: Three area industrial hygiene samples, three bulk bitumen samples and three reactor water samples were collected at a tar sands extraction facility at the University of Utah and analyzed for benzene solubles and polynuclear aromatic hydrocarbon (PNA) content. Benzene solubles and PNA content in the air and reactor water samples were below limits of detection.  Bulk bitumen samples contained a relatively large quantity of benzene soluble compounds (benzene solubles) and nine different PNAs were identified.  Qualitative and quantitative data relevant to the nine PNAs were obtained from analysis by high performance liquid chromatography utilizing ultraviolet absorption and fluorimetric detection.
Intracellular localization of Borrelia burgdorferi : implications for persistence, pathogenesis, and immune responsiveness of Lyme disease
Creators: name: Ma, Ying
Publisher: name: University of Utah
Year: 2012
Subjects: Pathology
Endothelial Cell

description: The later stages of Lyme disease are characterized by persistence of Borrelia burgdorferi organisms in the presence of a strong anti-B. burgdorferi immune response.  This suggests the B. burgdorferi may hide to avoid the defenses of the host or that there is a reservoir for the organisms in the host.  In this thesis project, it has been demonstrated that B. burgdorferi gain entrance into human umbilical vein endothelial cells and murine endothelial cells.  Incubation of two strains of B. burgdorferi with human and murine endothelial cells results in adhesion and invasion.  The intracellular location of the spirochetes was demonstrated by the incorporation of 3H-adenine labeled B. burgdorferi into a trypsin-resistant compartment and was confirmed by double-immunofluorescence staining, which discriminates intracellular from extracellular organisms.  Endothelia cell activation had not effect on the interaction of B burgdorferi with endothelia cells; however, B. burgdorferi infection did induce the endothelia cell product IL-6.  As IL-6 is an important inflammatory mediator, it may be involved in the pathology of Lyme disease.  Analysis of the antigen specific response of lymphocytes from infected animals allowed us to determine T cells were involved.  The establishment of an animal model will allow further studies on the role of the host immune response in the pathology associated with B. burgdorferi infection.
The retirement wealth of the early baby boomers
Creators: name: Lee, Amanda Jo
Publisher: name: University of Utah
Year: 2012
Subjects: Cohort
Retirement

description: The Baby Boomer cohort is larger than any previous, representing nearly one fourth of the population of the United States. Historically, they have influenced the economy of the united States as they entered into new life stages, and they have experienced economic prosperity and increased earnings through much of their working years. Now, as the Early Baby Boomers are on the verge of retiring, there are questions about how well prepared they are to live out their retirement years. Because of their savings habits, longer life expectancies, and changing economic conditions, they may face unique challenges not experienced by previous cohorts.
Laboratory diagnosis of fragile X syndrome by using rapid cycle polymerase chain reaction
Creators: name: Lee, Ming-Chih
Publisher: name: University of Utah
Year: 2012
Subjects: PCR Amplification
Polymerases

description: Fragile X syndrome in a common from of inherited mental retardation with an unusual inheritance pattern.  The responsible mutation, a large increase in the number of CGG repeats flanking the fragile X mental retardation 1 (FMR-1) gene on the X chromosome, has recently been described.  The polymerase chain reaction (PCR) has been used to amplify DNA across the region of CGG repeats to detect the mutation.  However, standard procedures take 4-6 hours with low amplification efficiency for long mutated genes that prevent visualization with ethidium bromide staining on agorose gels.  In this theses, factors that affect PCR amplification of the FMR-1 region have been systematically studied.  These include 1) optimal concentration of MgCl2, dimethyl sulfoxide (DMSO), and 7-deaza-2'deoxyguanosine 5'-triphosphat (7-deaza-dGTP); 2) temperature control of the reaction mixture before the initiation of PCR; 3) denaturation temperature during PCR; and 4) polymerase of polymerase combination used.  Optimal concentrations were 1.0 mM Mg2+ (wirh 200 upsilonM of each dNTP), 5-7.5% DNSo, and 0-25% 7-deaza-dGTP substitution of dGTP.  A  denaturation temperature of 97°C with a rapid temperature transition of the preamplification sample for 0° to 97°C enhanced amplification of high G+C products.  Combination of Taq and Pfu polymerase, or KlenTaq1 and Pfu polymerases where Pfu polymerase is used as a minor component with 3' through 5' proofreading activity allow the complete extension of long amplification products from abnormal FMR-1 genes.  With systematic optimization, genetic screening of at-risk populations for fragile X with PCR can be improved.
Briefkopierbuch "La. G"
Creators: name: Thurneysen & Cie
Publisher: name: [s.n.]
Year: 1857

description: Darin: Register, eingeklebte Seidenband-Webmuster
description: Deutsch, Französisch
description: Verzeichnung=Description=Inventaire 2014 ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Sebastian Preher
Perceptions of nurse administrators regarding the importance of needed administrative competencies.
Creators: name: Phillips, Robin L. and Phillips
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Socialization Theoies

description: The educational preparation a nurse administrator has received is thought to influence the professional socialization of the administrator.  The professional socialization influences the perceptions of the nurse administrator which then influence the actions of actions of the nurse administrator.  Does the advanced educational preparation of top nurse administrators significantly affect their perceptions of what are important competencies for today's nurse administrators?  An adaption of Nancy Goodrich's tool 'Determining the Type and Level of Competencies Needed by Nurse Administrators' was sent to 190 randomly selected, top nurse administrators employed by hospitals greater than 300 beds in the United States.  The result indicated nurse administrators with advanced educational degrees in nursing had significantly higher mean scores for the categories of education, nursing, personnel management, organizations, research, and trends in health care when compared to nurse administrators with advanced educational degrees in a non-nursing area.  Nurse administrators with an advanced educational degree in nursing administration were compared to nurse administrators with an advanced educational degree in any non-nursing area.  The nursing group differed significantly from the non-nursing group in only one category: Trends in Health Care. This nursing group consisted only of nurses with nursing administration degrees; those with advanced clinical degrees were not included in this nursing group. This suggested a major influence of clinical education in the socialization of nurse administrators.  Weak correlations were found between category scores of perceived importance and years as a registered nurse, years as a staff nurse, and years of management experience.
Sonnenfleckenzeichnung Nr. 23188.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.09.1969, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Regulated nuclear import of the adenomatous polyposis coli protein.
Creators: name: Zhang, Fang
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Proteins

description: Mutation of the Adenomatous Polyposis Coli (APC) gene is an early step in the development of colorectal carcinomas. To provide clues for APC's role in tumor suppression, the subcellular distribution of APC was studied, and APC was found to localize to both the cytoplasm and the nucleus of normal human epithelial cells. The objectives of this study were to characterize the intrinsic signals that mediate APC nuclear import, examine the regulation of APC's nuclear localization and its mechanism, and study the functional importance of this nuclear localization. Two functional nuclear localization signals (NLSs), NLS1[APC] and NLS2[APC], were identified. They were each sufficient to target the cytoplasmic protein beta-galactosidase to the nucleus, and they were both necessary for optimal nuclear import of full-length APC protein. To analyze how cellular context affects APC distribution, several cellular contexts were examined including cell density, cell cycle, cell-cell contact, and extracellular calcium. We determined that cell density, but not cell cycle, influenced APC's subcellular distribution. Further analysis of the two defined NLSs revealed that the adjacent potential CK2 and PKA sites regulated NLS2[APC]-mediated nuclear import. Phosphorylation at the CK2 site increased and phosphorylation at the PKA site decreased NLS2 APC
Sonnenfleckenzeichnung Nr. 23096.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.06.1969, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt