cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Addressing child and adolescent obesity management in Ireland: identifying facilitators and barriers in clinical practice
Creators: name: Ferdous, Farzana
name: Arthurs, Niamh
name: Tully, Louise
name: O'Brien, Sarah
name: Smith, Susan M.
name: Walsh, Aisling
name: O'GORMAN, CLODAGH
name: O'Malley, Grace
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background: Ireland’s Model of Care for the Management of Overweight and Obesity outlines a plan for treating adolescent and child obesity (CO). However, engagement with key stakeholders is required to support its implementation and improve health services. Aim: This study aims to map the perceived barriers and facilitators related to CO management across healthcare settings, professional disciplines, and regions in the Republic of Ireland (ROI). Materials and methods: An online cross-sectional survey of registered healthcare professionals (HPs), designed to adhere to the Consolidated Framework for Implementation Research (CFIR), was co-developed by a project team consisting of researchers, healthcare professionals, and patient advocates. The survey was pilot tested with project stakeholders and distributed online to professional groups and via a social media campaign, between September 2021 and May 2022, using “SurveyMonkey.” Data were summarised using descriptive statistics and thematic analyses. Themes were mapped to the CFIR framework to identify the type of implementation gaps that exist for treating obesity within the current health and social care system. Results: A total of 184 HPs completed the survey including nurses (18%), physicians (14%), health and social care professionals (60%), and other HPs (8%). The majority were female (91%), among which 54% reported conducting growth monitoring with a third (32.6%) giving a diagnosis of paediatric/adolescent obesity as part of their clinical practice. Nearly half (49%) of the HPs reported having the resources needed for clinical assessment. However, 31.5% of the HPs reported having enough “time,” and almost 10% of the HPs reported having no/ limited access to suitable anthropometric measurement tools. Most HPs did not conduct obesity-related clinical assessments beyond growth assessment, and 61% reported having no paediatric obesity training. CFIR mapping identified several facilitators and barriers including time for clinical encounters, suitable materials and equipment, adequate training, perceived professional competency and self-efficacy, human equality and child-centredness, relative priorities, local attitudes, referral protocols, and long waiting times. Conclusions: The findings provide actionable information to guide the implementation of the Model of Care for the Management of Overweight and Obesity in Ireland. Survey findings will now inform a qualitative study to explore implementation barriers and facilitators and prioritise actions to improve child and adolescent obesity management.
Inferring the composition of super-Jupiter mass companions of pulsars with radio line spectroscopy
Creators: name: Ray, Alak
name: Loeb, Abraham
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We propose using radio line spectroscopy to detect molecular absorption lines (such as OH at 1.6-1.7 GHz) before and after the total eclipse of black widow (BW) and other short orbital period binary pulsars with low mass companions. The companion in such a binary may be ablated away by energetic particles and high energy radiation produced by the pulsar wind. The observations will probe the eclipsing wind being ablated by the pulsar and constrain the nature of the companion and its surroundings. Maser emission from the interstellar medium stimulated by a pulsar beam might also be detected from the intrabinary medium. The short temporal resolution allowed by the millisecond pulsars can probe this medium with the high angular resolution of the pulsar beam.
description: Accepted for publication, ApJ. This version extends the discussion of equivalent width of molecular gas or HI absorption and the required signal to noise ratio. Molecule formation in the environment of ultra-low mass companions around pulsars and ways to distinguish interstellar vs in situ binary gas are discussed. A possible search through pulse gated spectral line interferometry is mentioned
A Multiband Generalization of the Analysis of Variance Period Estimation Algorithm and the Effect of Inter-band Observing Cadence on Period Recovery Rate
Creators: name: Mondrik, Nicholas
name: Long, James P.
name: Marshall, Jennifer L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present a new method of extending the single band Analysis of Variance period estimation algorithm to multiple bands. We use SDSS Stripe 82 RR Lyrae to show that in the case of low number of observations per band and non-simultaneous observations, improvements in period recovery rates of up to $\approx$60\% are observed. We also investigate the effect of inter-band observing cadence on period recovery rates. We find that using non-simultaneous observation times between bands is ideal for the multiband method, and using simultaneous multiband data is only marginally better than using single band data. These results will be particularly useful in planning observing cadences for wide-field astronomical imaging surveys such as LSST. They also have the potential to improve the extraction of transient data from surveys with few ($\lesssim 30$) observations per band across several bands, such as the Dark Energy Survey.
description: Submitted to ApJL, comments welcome at nmondrik@g.harvard.edu
On the meaning of Painlevé--Gullstrand synchronization
Creators: name: Jaén, Xavier
name: Molina, Alfred
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Following on from two recent papers, here we examine the relationship between Newtonian gravitation and general relativity in more depth. This allows us to define a scalar potential which is just the proper time of the vector potential when the latter is interpreted as the geodesic velocity field. The results are closely related to spacetimes that admit Painlevé--Gullstrand synchronization.
title: Prof. Dr. Paul Ganz-Kern
title: 5. Juli 1872 bis 28. August 1954
titleType: Subtitle
Creators: name: Morgenthaler, Robert
name: Huber, Max
name: Gantner, Joseph
name: Reinhardt, Hans
Publisher: name: [Verlag nicht ermittelbar]
Year: 1954
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Ganz, Paul
subject: Zürich
subject: Hilterfingen
subject: Basel

description: Inhalt: Lebenslauf ; Trauerrede von Herrn Pfarrer Robert Morgenthaler in der Kirche zu Hilterfingen am 31. August 1954 ; Zur Erinnerung an den Freund / Prof. Max Huber, Zürich ; Ansprache des Rektors der Universität Basel / Prof. Joseph Gantner, Basel ; Dankesworte eines Mitarbeiters / Prof. Hans Reinhardt, Basel
Salileptolyngbya Zhou 2018, gen. nov.
Creators: name: Zhou, Wei-Guo
name: Ding, De-Wen
name: Yang, Qing-Song
name: Ahmad, Manzoor
name: Zhang, Yuan-Zhou
name: Lin, Xian-Cheng
name: Zhang, Yan-Ying
name: Ling, Juan
name: Dong, Jun-De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Bacteria
Cyanobacteria
Cyanophyceae
Synechococcales
Leptolyngbyaceae
Salileptolyngbya

description: Salileptolyngbya Zhou, gen. nov.
Thallus blue-green. Filaments straight or curved to floating mats, without branching. Sheath thick, multilayer, covered the trichomes. Cells cylindrical and elongated, distinctly constricted at the cross wall.Apical cell rounded. Reproduction by hormogonia. Typical from saline environment.
 Type: — Salileptolyngbya diazotrophicum Zhou sp. nov
 Etymology: —the genus name “ Salileptolyngbya ” refers to its habitat in saline environment and similar morphology to Leptolyngbya sensu stricto.
description: Published as part of Zhou, Wei-Guo, Ding, De-Wen, Yang, Qing-Song, Ahmad, Manzoor, Zhang, Yuan-Zhou, Lin, Xian-Cheng, Zhang, Yan-Ying, Ling, Juan & Dong, Jun-De, 2018, Marileptolyngbya sina gen. nov., sp. nov. and Salileptolyngbya diazotrophicum gen. nov., sp. nov. (Synechococcales, Cyanobacteria), species of cyanobacteria isolated from a marine ecosystem, pp. 75-92 in Phytotaxa 383 (1) on page 79, DOI: 10.11646/phytotaxa.383.1.4, http://zenodo.org/record/13725105
title: Detecting Software Attacks on Embedded IoT Devices
Creators: name: Kumar, Seema
Publisher: name: UNSPECIFIED
Year: 2023

description: Internet of Things (IoT) applications are being rapidly deployed in the context of smart homes, automotive vehicles, smart factories, and many more. In these applications, embedded devices are widely used as sensors, actuators, or edge nodes. The embedded devices operate distinctively on a task or interact with each other to collectively perform certain tasks. In general, increase in Internet-connected things has made embedded devices an attractive target for various cyber attacks, where an attacker gains access and control remote devices for malicious activities. These IoT devices could be exploited by an attacker to compromise the security of victim’s platform without requiring any physical hardware access. In order to detect such software attacks and ensure a reliable and trustworthy IoT application, it is crucial to verify that a device is not compromised by malicious software, and also assert correct execution of the program. In the literature, solutions based on remote attestation, anomaly detection, control-flow and data-flow integrity have been proposed to detect software attacks. However, these solutions have limited applicability in terms of target deployments and attack detection, which we inspect thoroughly. In this dissertation, we propose three solutions to detect software attacks on embedded IoT devices. In particular, we first propose SWARNA, which uses remote attestation to verify a large network of embedded devices and ensure that the application software on the device is not tampered. Verifying the integrity of a software preserves the static properties of a device. To secure the devices from various software attacks, it is imperative to also ensure that the runtime execution of a program is as expected. Therefore, we focus extensively on detecting memory corruption attacks that may occur during the program execution. Furthermore, we propose, SPADE and OPADE, secure program anomaly detection that runs on embedded IoT devices and use deep learning, and machine learning algorithms respectively to detect various runtime software attacks. We evaluate and analyse all the proposed solutions on real embedded hardware and IoT testbeds. We also perform a thorough security analysis to show how the proposed solutions can detect various software attacks.
Enabling Design Space Exploration of RISC-V Accelerator-rich Computing Systems on gem5
Creators: name: Chatzopoulos, Odysseas
name: Papadimitriou, George
name: Karakostas, Vasileios
name: Gizopoulos, Dimitris
Publisher: name: Zenodo
Year: 2023
Subjects: gem5
domain-specific accelerators
performance modeling
RISC-V

description: In this paper we describe our effort to port gem5-SALAM, a cutting-edge pre-RTL heterogeneous SoC simulator, to incorporate general-purpose RISC-V cores. In such a way, we provide to the RISC-V community a powerful tool to design, evaluate and optimize such systems.
Search for precursor eruptions among Type IIb supernovae
Creators: name: Strotjohann, Nora L.
name: Ofek, Eran O.
name: Gal-Yam, Avishay
name: Sullivan, Mark
name: Kulkarni, Shrinivas R.
name: Shaviv, Nir J.
name: Fremling, Christoffer
name: Kasliwal, Mansi M.
name: Nugent, Peter E.
name: Cao, Yi
name: Arcavi, Iair
name: Sollerman, Jesper
name: Filippenko, Alexei V.
name: Yaron, Ofer
name: Laher, Russ
name: Surace, Jason
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The progenitor stars of several Type IIb supernovae (SNe) show indications for extended hydrogen envelopes. These envelopes might be the outcome of luminous energetic pre-explosion events, so-called precursor eruptions. We use the Palomar Transient Factory (PTF) pre-explosion observations of a sample of 27 nearby Type IIb SNe to look for such precursors during the final years prior to the SN explosion. No precursors are found when combining the observations in 15-day bins, and we calculate the absolute-magnitude-dependent upper limit on the precursor rate. At the 90% confidence level, Type IIb SNe have on average $<0.86$ precursors as bright as absolute $R$-band magnitude $-14$ in the final 3.5 years before the explosion and $<0.56$ events over the final year. In contrast, precursors among SNe IIn have a $\gtrsim 5$ times higher rate. The kinetic energy required to unbind a low-mass stellar envelope is comparable to the radiated energy of a few-weeks-long precursor which would be detectable for the closest SNe in our sample. Therefore, mass ejections, if they are common in such SNe, are radiatively inefficient or have durations longer than months. Indeed, when using 60-day bins a faint precursor candidate is detected prior to SN 2012cs ($\sim2$% false-alarm probability). We also report the detection of the progenitor of SN 2011dh which does not show detectable variability over the final two years before the explosion. The suggested progenitor of SN 2012P is still present, and hence is likely a compact star cluster, or an unrelated object.
description: 16 pages, 10 figures
A twisted bicanonical system with base points
Creators: name: Favale, Filippo F.
name: Pignatelli, Roberto
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14J29

description: By a theorem of Reider, a twisted bicanonical system, that means a linear system of divisors numerically equivalent to a bicanonical divisor, on a minimal surface of general type, is base point free if $K^2_S \geq 5$. Twisted bicanonical systems with base points are known in literature only for $K^2=1,2$. We prove in this paper that all surfaces in a family of surfaces with $K^2=3$ constructed in a previous paper with G. Bini and J. Neves have a twisted bicanonical system (different from the bicanonical system) with two base points. We show that the map induced by the above twisted bicanonical system is birational, and describe in detail the closure of its image and its singular locus. Inspired by this description, we reduced the problem of constructing a minimal surface of general type with $K^2=3$ whose bicanonical system has base points, under some reasonable assumptions, to the problem of constructing a curve in $\mathbb{P}^3$ with certain properties.
description: 20 pages. Corrected an error in Theorem 3. Some arguments have been simplified. To appear on Annali dell'Universit\`a di Ferrara, in a special volume dedicated to the memory of Alexandru Lascu
Child, family and community factors associated with child emotional and behavioural problems
Creators: name: Coughlan-Ward, Vicky
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: During childhood and adolescence the family and social environments in which children live converge to increase the likelihood of income-related risk factors and the developmentof emotional and behavioural problems that continue into adulthood. The current studyexamined the associations among child and caregiver demographics including age and sex,physical and mental health of caregiver, physical health of child, family circumstancesincluding high- or low-income and housing, and the experience of child mental healthproblems such as depression and rule-breaking behaviours and simultaneously sought toevaluate whether connectedness to school served as a protective factor between low-incomeand child mental health problems. Participants in the current small cross-sectional studywere 56 children aged 11-17 years and their caregivers recruited from 3 Catholic schoolsand 6 Salvation Army Community Centres in Melbourne. Results showed that there was astrong association between low-income, poor child physical health, poor caregiver mentalhealth and child emotional and behavioural problems; and that high level of school connectedness was associated with decreases in symptoms. These results suggest that children from low-income families are particularly vulnerable to mental health problemsand are discussed in the context of positive development of children and adolescents.
Human Immunodeficiency Virus Testing Practices and Interest in Self-Testing Options Among Young, Black Men Who Have Sex With Men in North Carolina
Creators: name: Miller, William C.
name: Hurt, Christopher B.
name: Hightow-Weidman, Lisa B.
name: Soni, Karina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Young, Black men who have sex with men (YBMSM) experience disproportionately high HIV incidence in the United States. Relative to other at-risk populations, less is known about their HIV testing behaviors and preferences regarding self-testing.
Regulated mis-expression of PDX1 and NKX6.1 during pancreatic differentiation of pluripotent stem cells
Creators: name: Tan, Gemma
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Human pluripotent stem cells represent a potential source of pancreatic beta cells for the treatment of type 1 diabetes. Methods for generating pancreatic endoderm from pluripotent stem cells are becoming increasingly robust, although the general applicability of any given method to a broad range of stem cell lines remains a challenge. Therefore, a deeper understanding of the molecular mechanisms controlling the commitment of cells to pancreatic endoderm is desirable. A key step in this process is the co-ordinated up-regulation of two transcription factors, PDX1 and NKX6.1; factors that together identify cells fated to become pancreatic endoderm and to later give rise to endocrine cells. In this thesis, we examined the effects of overexpressing PDX1 and NKX6.1 during the course of PSC differentiation. We employed the use of a number of transgenic systems, namely the doxycycline inducible Tet-On expression system, Destabilisation Domains (DD) and Estrogen Receptor (ER) fusion proteins. Our experiments demonstrated a potential for each of the 3 expression systems, however we encountered drawbacks within each one preventing us from establishing a definitive conclusion as to the affects of over-expressing PDX1 and NKX6.1 during PSC differentiation. We conclude that only once both the expression systems and differentiation protocols are optimised will it be possible to determine the effects of co-expressing these two factors during the course of pancreatic differentiation.
Lieb-Liniger model with exponentially-decaying interactions: a continuous matrix product state study
Creators: name: Rincon, Julian
name: Ganahl, Martin
name: Vidal, Guifre
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Lieb-Liniger model describes one-dimensional bosons interacting through a repulsive contact potential. In this work, we introduce an extended version of this model by replacing the contact potential with a decaying exponential. Using the recently developed continuous matrix product states techniques, we explore the ground state phase diagram of this model by examining the superfluid and density correlation functions. At weak coupling superfluidity governs the ground state, in a similar way as in the Lieb-Liniger model. However, at strong coupling quasi-crystal and super-Tonks-Girardeau regimes are also found, which are not present in the original Lieb-Liniger case. Therefore the presence of the exponentially-decaying potential leads to a superfluid/super-Tonks-Girardeau/quasi-crystal crossover, when tuning the coupling strength from weak to strong interactions. This corresponds to a Luttinger liquid parameter in the range $K \in (0, \infty)$; in contrast with the Lieb-Liniger model, where $K \in [1, \infty)$, and the screened long-range potential, where $K \in (0, 1]$.
description: 10 pages, 8 figures
A fundamental step-up method for standard voltage transformers based on an active capacitive high-voltage divider
Creators: name: Mohns, Enrico
name: Chunyang, Jiang
name: Badura, Henrik
name: Räther, Peter
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2019
Subjects: Capacitive divider
high voltage
inductive voltage divider (IVD)
phase displacement
ratio error
uncertainty
voltage transformer (VT)

description: This paper presents the new fundamental step-up method for standard voltage transformers (VTs) at the Physikalisch-Technische Bundesanstalt, as well as the setup of the required components. A main component is an active low-voltage capacitor, designed to realize capacitive voltage dividers by means of compressed gas, high-voltage capacitors for rated primary voltages between 5 kV and 800 kV/√ 3. This divider has a negligible voltage dependence and low phase errors at 50/60 Hz. Using the other components, mainly a two-stage VT with integrated inductive voltage divider and a sampling-based voltage comparator, a transfer uncertainty for one build-up step of below 1· 10⁻⁶ (k = 2) has been reached.
Supplementary material for "Communication protocol for a satellite-swarm interferometer" - additional plots for simulation study of coverage
Creators: name: Nagy, Oliver
name: Pandey, Manish
name: Exarchakos, Georgios
name: Bentum, Mark
name: van der Hofstad, Remco
Publisher: name: Zenodo
Year: 2023

description: Supplementary material for "Communication protocol for a satellite-swarm interferometer" - plots for simulation study of coverage.
 Files are bundled inside a .zip archive. The naming scheme of the files is as follows:  fig_{descriptor}_{k}_{p}_{beta}.pdf  where {descriptor} can be "fracLSCC" for plots related to LSCC reduction parameter ρL, "coverLSCC" for LSSC coverage αL and "coverALL" for coverage parameter α. Placeholder {k} corresponds to the value of k chosen in the simulation, p denotes the chosen value of p and {beta} shows the chosen value of β. For ρL, which is independent of β, the naming convention uses β = 1. For example, fig_coverALL_5-0.980-0.700.pdf corresponds to the plot of the coverage parameter α for networks with k = 5, p = 0.98 and β = 0.7.
Influence of Detection Method and Study Area Scale on Syphilis Cluster Identification in North Carolina
Creators: name: Gesink, Dionne C.
name: Samoff, Erika
name: Emch, Michael
name: Serre, Marc L.
name: Escamilla, Veronica
name: Leone, Peter A.
name: Miller, William C.
name: Hampton, Kristen H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Identifying geographical clusters of sexually transmitted infections can aid in targeting prevention and control efforts. However, detectable clusters can vary between detection methods because of different underlying assumptions. Furthermore, because disease burden is not geographically homogenous, the reference population is sensitive to the study area scale, affecting cluster outcomes. We investigated the influence of cluster detection method and geographical scale on syphilis cluster detection in Mecklenburg County, North Carolina.
Tau lepton reconstruction at collider experiments using impact parameters
Creators: name: Jeans, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present a novel method for the reconstruction of events containing pairs of hadronically decaying tau leptons at collider experiments. This method relies on accurate knowledge of the tau production vertex and precise measurement of its charged decay products. The method makes no assumptions about the centre-of-mass or invariant mass of the tau pair, and is insensitive to momentum loss along the beam direction. We demonstrate the method using e+e- -> mu+ mu- tau+ tau- events fully simulated in the ILD detector.
Saxicolella Encl.
Creators: name: Cheek, Martin
name: Molmou, Denise
name: Magassouba, Sekou
name: Ghogue, Jean-Paul
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Podostemaceae
Saxicolella

description: Subgenus 1. Saxicolella Type species: Sapicolella nana Engl. Roots approximately disc-like, crustose, with short radiating marginal lobes (where known). Shoots arising from the centre of the crustose root, forming distinctly visible stems with visible internodes; leaves with well-developed leafblades, far longer than the bases, usually bifurcating or trifurcating (usually entire in Sapicolella ijim), stipules present. DISTRIBUTION. Nigeria, Cameroon and Angola. ETYMOLOGY. Autonym, taking the name of the genus. Species 1 – 3: Sapicolella flabellata (G.Taylor), C.Cusset, S.ijim Cheek, S. angola Cheek, S. nana Engl.
description: Published as part of Cheek, Martin, Molmou, Denise, Magassouba, Sekou & Ghogue, Jean-Paul, 2022, Taxonomic revision of Saxicolella (Podostemaceae), African waterfall plants highly threatened by Hydro-Electric projects, pp. 403-433 in Kew Bulletin 77 (2) on page 410, DOI: 10.1007/s12225-022-10019-2, http://zenodo.org/record/7599361
Clinical associations and prognostic significance of mitotic rate in primary cutaneous melanoma
Creators: name: Shen, Sarah
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Melanoma is a significant cause of morbidity and mortality in Australia. Whilst recent developments in targeted therapies have offered exciting breakthroughs in the treatment of advanced disease, survival rate remains grim for those afflicted with the systemic spread of melanoma. For local cutaneous disease, a patient’s initial prognosis is primarily determined by the stage which the melanoma is first diagnosed, reflected largely but not solely by its Breslow thickness. Attempts are being made to better understand both the clinical and histologic heterogeneity of melanoma, since it is recognized that some subtypes of melanoma behave more aggressively than others. This thesis aims to examine the distinct clinical and histopathologic features of aggressive primary cutaneous melanomas, as a means to aid clinicians with timely detection of at-risk individuals. It also aims to extend upon our current knowledge of melanoma prognostication. In order to pursue these aims, two original studies were undertaken; both focused on mitotic rate, a histologic feature used to quantify the degree of tumour cell proliferation and has emerged in recent years as an important prognosticator of clinical outcomes. The first study of this thesis seeks to elucidate patient and tumour characteristics associated with mitotically active melanoma. The predictive value of mitotic rate for melanoma survival was explored in the second study.
Linkage and Referral to HIV and Other Medical and Social Services: A Focused Literature Review for Sexually Transmitted Disease Prevention and Control Programs
Creators: name: Carter, Marion W.
name: Hightow-Weidman, Lisa
name: Cohen, Stephanie
name: Peters, Philip J.
name: Lecher, Shirley Lee
name: Wu, Hsiu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: BACKGROUND: Sexually transmitted disease (STD) program and clinic staff play an important role in providing linkage and referrals to programs and services that address the complex medical and psychosocial needs of their clients. We synthesized recent published literature related to effective practices for linkage to care for HIV and referral to other medical and social services.

METHODS: Three PubMed searches were conducted to identify relevant studies published since 2004 on (1) linkage to HIV care, (2) referral within STD clinical contexts, and (3) (review articles only) referral practices among all medical specialties. Systematic review procedures were not used.

RESULTS: Thirty-three studies were included in this review. Studies highlight the limited value of passive referral practices and the increased effectiveness of active referral and linkage practices. Numerous studies on linkage to HIV care suggest that case management approaches, cultural-linguistic concordance between linkage staff and clients, and structural features such as colocation facilitate timely linkage to care. Integration of other medical and social services such as family planning and alcohol screening services into STD settings may be optimal but resource-intensive. Active referral practices such as having a written referral protocols and agreements, using information technology to help transfer information between providers, and making appointments for clients may offer some benefit. Few studies included information on program costs associated with linkage and referral.

CONCLUSIONS: Recent literature provides some guideposts for STD program and clinical staff to use in determining their approach to helping link and refer clients to needed care. Much experience with these issues within STD services remains unpublished, and key gaps in the literature remain.
The evaluation of the Aged Care Graduate Nurse Program
Creators: name: Fengler, Fernanda Laís
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Introduction: Universally the aging population is increasing in numbers as people live longer. In Australia, for example, the percentage of people aged 65 years and over exceeds 11.7% with an annual percentage increase of more than 3.1% (Australian Government, 2012). For that reason since 1985 Australia has been developing a new Aged Care Reform Strategy to assist in the management of this increasing aged population (Australian Government, 2012). Monash University, in collaboration with a leading Aged Care industry body, developed and delivered the first Aged Care Graduate Nurse Program (ACGNP) in 2012. The purpose of this program was to prepare newly graduated Registered Nurses (RNs) to work with older adults. Aim: This honours thesis provided part of the overall evaluation of the ACGNP. Using the overarching Clarificative Evaluation framework the aim of this honours project was to investigate and analyse the qualitative data from the graduate participants who undertook the 2013 program which then informed the overall program evaluation. Methods: Firstly, a broad summative literature review was undertaken to identify relevant literature on the key areas of the overall evaluation. Secondly, qualitative data collected from the 2013 were used to investigate the graduates’ understanding and experience of their participation in the Graduate Nursing Program. Thematic analysis was the method used to analyse the qualitative data Results: In total, there were 27 participants (5 males and 22 females) spread across three focus groups (Focus Group 07, 08 and 09) at the end of the program, 2013. Five core themes emerged: 1. Entry into the program; 2. Learning; 3. Workplace Supervision; 4. Updating workplace clinical practices; 5. Positive course outcomes. The first two themes relate to the educational program at the University, and the last three themes relate to the workplace. Discussion: It was considered an easy process to enter into the program. The course was considered to have had a good structure and some issues of participants’ interest were included. However, some of the participants identified that resources were sometimes inadequate. As the graduates progressed through the program they wanted to be seen as competent professionals within their workplace, and it was identified that the workplace was not always conducive to developing this competence. However, overall the graduates felt the program achieved it’s overall purpose and there was a significant increase in knowledge, skills and confidence. Conclusion: According to the research aim this thesis using the overarching Clarificative Evaluation framework contributed significantly to the overall evaluation of the Aged Care Graduate Nursing Program.
Identification of novel LRH-1 target genes in breast cancer cells
Creators: name: Zhao, Zhe
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The orphan nuclear receptor liver receptor homolog-1 (LRH-1) plays important roles in embryonic development, lipid homeostasis and steroidogenesis, and has been implicated in driving several cancers. In breast cancer, LRH-1 is expressed in tumour epithelial cells of invasive ductal carcinomas. We hypothesized that LRH-1 regulates epithelial cell proliferation and invasiveness to drive breast tumour progression. The overall goal of this study was to identify molecular mechanisms regulated by LRH-1 related to cell proliferation and epithelial to mesenchymal transition (EMT). Previously, expression-profiling experiments identified the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family as potential LRH-1 target genes. The specific aim of this project was to define the effects of LRH-l on hnRNPA1 and hnRNPA2 gene expression, cell proliferation and EMT using normal and transformed human mammary epithelial cell lines as models. The siRNA-mediated knockdown of LRH-1 significantly decreased expression of hnRNPs at the mRNA and protein levels. This correlated with reduced cell proliferation, an effect that was potentiated when hnRNPA1 were knocked down in parallel. Evidence was also obtained to suggest that alternative splicing of the hnRNPs-regulated enzyme pyruvate kinase resulted in a switch in energy metabolism (from aerobic glycolysis to oxidative phosphorylation) that contributes to increased cell proliferation. Using a well-established model of EMT (the hMLE epithelial cell line), we demonstrated that LRH-1 expression increases during TGFβ-induced EMT, and that knockdown of LRH-l partially reverses the EMT phenotype. hnRNPs expression decreased during EMT, however, and knockdown experiments did not support a role for LRH-1 induced hnRNPs expression in EMT. In conclusion, this study has identified hnRNPs family as LRH-1 target genes. The data support a role for LRH-1 in mediating breast cancer proliferation via multiple mechanisms, including metabolic regulation. We also demonstrate an important role for LRH-1 in EMT, although LRH-1-induced hnRNPs expression does not appear to be involved in this process.
Primary Care Physiciansʼ Adherence to Expert Recommendations for Cervical Cancer Screening and Prevention in the Context of Human Papillomavirus Vaccination
Creators: name: Perkins, Rebecca B.
name: Vadaparampil, Susan T.
name: Malo, Teri L.
name: Lee, Ji-Hyun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: BACKGROUND: Expert recommendations do not recommend using Papanicolaou (Pap) or human papillomavirus (HPV) test results to determine whether unvaccinated women should receive HPV vaccine, nor do they recommend using vaccine receipt to inform cervical cancer screening practices. This study characterizes physicians' HPV vaccine recommendations and practices in the context of HPV and Pap testing.

METHODS: We surveyed family physicians and obstetrician-gynecologists randomly selected from the American Medical Association Masterfile in 2011 (n = 574). Physicians used a 5-point scale (never to always) to report the frequency of (1) using HPV testing results to decide whether to recommend HPV vaccine, and (2) recommending HPV vaccination to women (≤26 years) who had an abnormal Pap test. Physicians also reported (3) intention to change Pap screening frequency for vaccinated women.

RESULTS: Across both specialties, 80% correctly reported rarely or never using HPV testing results to guide vaccine recommendations; 66% often or always recommended vaccination to patients with an abnormal Pap result; and 77% did not plan to change Pap screening frequency for vaccinated women. About 41% reported recommendation-consistent practices with all 3 measures. In multivariable analysis, obstetrician-gynecologist specialty and private practice type were associated with higher average overall adherence to recommendations.

CONCLUSIONS: Contrary to expert recommendations, a considerable minority of physicians reported recommending HPV vaccination based on HPV and Pap test results. If these clinical practices persist, many young adult women will not realize the benefits of HPV vaccination. Additional efforts are needed to ensure all young women are screened and vaccinated appropriately.
Public Housing Relocations and Partnership Dynamics in Areas With High Prevalences of Sexually Transmitted Infections
Creators: name: Rothenberg, Richard
name: Adimora, Adaora A.
name: Linton, Sabriya
name: Bonney, Loida
name: Hunter-Jones, Josalin
name: Luo, Ruiyan
name: Haley, Danielle F.
name: Ross, Zev
name: Wingood, Gina M.
name: Cooper, Hannah L.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We investigated the implications of one structural intervention—public housing relocations—for partnership dynamics among individuals living areas with high sexually transmitted infection (STI) prevalence. High-prevalence areas fuel STI endemicity and are perpetuated by spatially assortative partnerships.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency phenotype and genotype profile in Kodi Sub-district, West Sumba, Indonesia
Creators: name: Yudhaputri, Frilasita Aisyah
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Primaquine is the only drug licensed for prevention of relapse in vivax and ovale malarias. It causes mild to severe hemolysis when administered to patients with G6PD deficiency. Because current methods for identifying these patients are not well-suited to care in malaria endemic areas like those in Indonesia, most patients do not receive anti-relapse therapy. This study examined a new rapid diagnostic test for G6PD deficiency (Carestart™ G6PD diagnostic kit, AccessBio, New Jersey) that requires no cold chain, and no specialized training or equipment. A validated ROT for G6PD would permit far broader application of primaquine in the prevention, control and treatment of malaria. The general objective of the work described in this thesis is to evaluate the sensitivity and specificity of a Carestart™ G6PD diagnostic kit and provide G6PD phenotype and genotype profile in Wainyapu Village, Kodi Sub-district, West Sumba District, East Nusa Tenggara Province, Indonesia, an area of hypo- to meso-endemic falciparum and vivax malaria. In summary, the following aspects have been studied: 1. Performance of a G6PD Rapid Diagnostic Test. In November 2010 we surveyed 1090 randomly selected residents of Wainyapu. In the field we conducted the experimental G6PD RDT test alongside (in blinded fashion) a standard qualitative test dye reduction kit, and a surrogate G6PD quantitative gold standard. The results indicate that the RDT has superior specificity and inferior sensitivity compared to the qualitative dye reduction test. 2. G6PD Molecular variant profile of Wainyapu Village, West Sumba, Indonesia. G6PD Molecular profile of the study population was carried out on 30 randomly selected samples consisting of 20 G6PD deficient individuals and 10 G6PD normal individuals. Full exon sequencing revealed the finding of 5 different G6PD variants and evidence on historical antecedents of human migration from these regions to Indonesia in considerable numbers during several thousand years.
High-efficiency and low-jitter Silicon single-photon avalanche diodes based on nanophotonic absorption enhancement
Creators: name: Ma, Jian
name: Zhou, Ming
name: Yu, Zongfu
name: Jiang, Xiao
name: Huo, Yijie
name: Zang, Kai
name: Zhang, Jun
name: Harris, James S.
name: Jin, Ge
name: Zhang, Qiang
name: Pan, Jian-Wei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Silicon single-photon avalanche diode (SPAD) is a core device for single-photon detection in the visible and the near-infrared range, and widely used in many applications. However, due to limits of the structure design and device fabrication for current silicon SPADs, the key parameters of detection befficiency and timing jitter are often forced to compromise. Here, we propose a nanostructured silicon SPAD, which achieves high detection efficiency with excellent timing jitter simultaneously over a broad spectral range. The optical and electric simulations show significant performance enhancement compared with conventional silicon SPAD devices. This nanostructured devices can be easily fabricated and thus well suited for practical applications.
description: 7 pages, 6 figures
CBS News Poll: Woman on the Twenty Dollar Bill
Creators: name: CBS News
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Woman to replace Andrew Jackson as the face of the twenty dollar bill (1); Eleanor Roosevelt, Rosa Parks, Betsy Ross, Amelia Earhart, Sojourner Truth, Sally Ride, Clara Barton, Georgia O'Keeffe (1); religious affiliation (1); personal finances (1); political party preference (1).
Rapid Diagnosis of Trichomonas vaginalis by Testing Vaginal Swabs in an Isothermal Helicase-Dependent AmpliVue Assay
Creators: name: Coleman, Jenell S.
name: Jang, Dan
name: Schwebke, Jane
name: Hobbs, Marcia
name: Gaydos, Charlotte A.
name: Marrazzo, Jeanne
name: Dize, Laura
name: Masek, Billie
name: Chernesky, Max
name: Li, Jenny
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The AmpliVue™ Trichomonas Assay (Quidel) is a new FDA cleared rapid test for qualitative detection of Trichomonas vaginalis (TV) DNA in female vaginal specimens. The assay is based on BioHelix’s Helicase-Dependent Amplification (HDA) isothermal technology in conjunction with a disposable lateral-flow detection device, with a total turn-around time of approximately 45 minutes.
UFCORIN: A Fully Automated Predictor of Solar Flares in GOES X-Ray Flux
Creators: name: Muranushi, Takayuki
name: Shibayama, Takuya
name: Muranushi, Yuko Hada
name: Isobe, Hiroaki
name: Nemoto, Shigeru
name: Komazaki, Kenji
name: Shibata, Kazunari
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have developed UFCORIN, a platform for studying and automating space weather prediction. Using our system we have tested 6,160 different combinations of SDO/HMI data as input data, and simulated the prediction of GOES X-ray flux for 2 years (2011-2012) with one-hour cadence. We have found that direct comparison of the true skill statistics (TSS) from small cross-validation sets is ill-posed, and used the standard scores ($z$) of the TSS to compare the performance of the various prediction strategies. The $z$ of a strategy is a stochastic variable of the stochastically-chosen cross-validation dataset, and the $z$ for the three strategies best at predicting X, $\geq$M and $\geq$C class flares are better than the average $z$ of the 6,160 strategies by 2.3$σ$, 2.1$σ$, 3.8$σ$ confidence levels, respectively. The best three TSS values were $0.75\pm0.07$, $0.48\pm0.02$, and $0.56\pm0.04$, respectively.
description: 47 pages, 11 figures, accepted for publication in Space Weather: http://onlinelibrary.wiley.com/doi/10.1002/2015SW001257/full
A study of Plasmodium vivax Duffy binding protein (DBP) in West Papuan isolates
Creators: name: Kusuma, Andreas
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The invasion of immature red blood cells called reticulocytes is a critical event for the Plasmodium vivax merozoite to continue its life-cycle in humans. Plasmodium vivax employs the Duffy binding protein (DBP) ligand to engage its host receptor, the Duffy antigen receptor for chemokines (DARC), in initiating the essential formation of a tight junction between the merozoite and erythrocyte for reticulocyte invasion. Because of this critical step, PvDBP is a promising antigen to be developed as vaccine against P. vivax infection. However, genetic diversity of this putative vaccine antigen particularly in the central domain of region II of DBP that serves as the critical binding motif to the DARC might pose a serious problem in designing an effective vaccine which elicits neutralizing immunity toward this ligand. Information about PvDBPIl polymorphisms has so far been obtained from the Papua New Guinea (PNG), Colombia, Iran, Korea, Brazil, and Thailand, but none reported from Indonesia. This thesis seeks to develop a better understanding of the host-parasite interaction by characterizing the extent of polymorphisms of PvDBPII from clinical isolates obtained from Timika on the south central coast of Papua, Indonesia. Sequence analyses of nucleotide and amino acid of PvDBPII obtained from Timikan isolates, demonstrated that P. vivax populations from Indonesia were genetically highly diverse, as shown by the large number of substitutions found in this region of DBP compared with the reference strain, Sal-I. Mutations were dominated by non-synonymous substitutions resulting in amino acid changes and mainly occurred in the critical binding motif of PvDBPII. Statistical analyses and the presence of polymorphisms associated with neutralizing B-cell linear epitopes confirmed the action of positive selection by host immune pressure to region II of PvDBP among Timikan isolates, which may play an important role in generating and maintaining certain haplotypes in P. vivax populations circulating in Timika. The study presented in this thesis revealed that the most prevalent substitutions found in Indonesia are also observed in other distinct geographical regions. Furthermore, the phylogenetic tree study showed that Timikan PvDBPII isolates clustered together with isolates from certain other geographic regions, including Brazil, Sri Lanka, and Papua New Guinea. In this study, we also produced an allele of PvDBPII-INA21 type as full-length sequence recombinant protein, expressed in E. coli bacterial system, to be used for serological assay. Western blot analysis demonstrated that most sera tested from P. vivax-infected individuals living in P. vivax highly endemic area Timika, Papua, Indonesia, contained antibodies that responded to this recombinant of PvDBPII derived from INA21 haplotype. This suggested cross-reactivity of Timikan sera to conserved PvDBP antigens.
Vanderbilt University Poll: Tennessee Poll Fall 2018
Creators: name: Vanderbilt University
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: President Donald Trump job performance (1); Congress job performance (1); Tennessee State Legislature job performance (1); Governor Bill Haslam job performance (1); Senator Lamar Alexander job performance (1); Senator Bob Corker job performance (1); opinion of public figures (4); Tennessee state government priorities (12); Governor Bill Lee's priorities (12); economic situation of the country (1); economic situation of Tennessee (1); Trump changing Washington (1); Trump telling the truth (1); views of bipartisanship (1); feelings about national government performance (1); feelings about state government performance (1); tariffs (1); illegal immigrants (2); health care system (1); state Medicaid expansion (1); legal immigrants (1); personal financial situation (1); federal government help to rural vs. urban areas (1); state government help to rural vs. urban areas (1); opioid addiction (2); border security (1); sports betting (1); public school priorities (1); vocational/technical education (1); school vouchers (1); undocumented immigrants (1); trust in media (1).