cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Thermodynamic relations for entropy and temperature of multi-horizons black holes
Creators: name: Xu, Wei
name: Wang, Jia
name: Meng, Xin-he
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present some entropy and temperature relations of multi-horizons, even including the "virtual" horizon. These relations are related to product, division and sum of entropy and temperature of multi-horizons. We obtain the additional thermodynamic relations of both static and rotating black holes in three and four dimensional (A)dS spacetime. Especially, a new dimensionless, charges-independence and $T_+S_+=T_-S_-$ like relation is presented. This relation does not depend on the mass, electric charge, angular momentum and cosmological constant, as it is always a constant. These relations lead us to get some interesting thermodynamic bound of entropy and temperature, including the Penrose inequality which is the first geometrical inequality of black holes. Besides, based on these new relations, one can obtain the first law of thermodynamics and Smarr relation for all horizons of black hole.
description: 12 pages, no figures, title changed, references added
Construction A of Lattices over Number Fields and Block Fading Wiretap Coding
Creators: name: Kositwattanarerk, Wittawat
name: Ong, Soon Sheng
name: Oggier, Frédérique
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: Number Theory (math.NT)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We propose a lattice construction from totally real and CM fields, which naturally generalizes the Construction A of lattices from $p$-ary codes obtained from the cyclotomic field $\mathbb{Q}(ζ_p)$, $p$ a prime, which in turn contains the so-called Construction A of lattices from binary codes as a particular case. We focus on the maximal totally real subfield $\mathbb{Q}(ζ_{p^r}+ζ_{p}^{-r})$ of the cyclotomic field $\mathbb{Q}(ζ_{p^r})$, $r\geq 1$. Our construction has applications to coset encoding of algebraic lattice codes, and we detail the case of coset encoding of block fading wiretap codes.
description: Submitted to IEEE Transactions on Information Theory
Massive gravitational waves in Chern-Simons modified gravity
Creators: name: Myung, Yun Soo
name: Moon, Taeyoon
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the nondynamical Chern-Simons (nCS) modified gravity, which is regarded as a parity-odd theory of massive gravity in four dimensions. We first find polarization modes of gravitational waves for $θ=x/μ$ in nCS modified gravity by using the Newman-Penrose formalism where the null complex tetrad is necessary to specify gravitational waves. We show that in the Newman-Penrose formalism, the number of polarization modes is one in addition to an unspecified $Ψ_4$, implying three degrees of freedom for $θ=x/μ$. This compares with two for a canonical embedding of $θ=t/μ$. Also, if one introduces the Ricci tensor formalism to describe a massive graviton arising from the nCS modified gravity, one finds one massive mode after making second-order wave equations, which is compared to five found from the parity-even Einstein-Weyl gravity.
description: 1+12 pages, 1 figure, version accepted for publication in JCAP
Constraining Sub-Parsec Binary Supermassive Black Holes in Quasars with Multi-Epoch Spectroscopy. II. The Population with Kinematically Offset Broad Balmer Emission Lines
Creators: name: Liu, Xin
name: Shen, Yue
name: Bian, Fuyan
name: Loeb, Abraham
name: Tremaine, Scott
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: A small fraction of quasars have long been known to show bulk velocity offsets in the broad Balmer lines with respect to the systemic redshift of the host galaxy. Models to explain these offsets usually invoke broad-line region gas kinematics/asymmetry around single black holes (BHs), orbital motion of massive (~sub-pc) binary black holes (BBHs), or recoil BHs, but single-epoch spectra are unable to distinguish between these scenarios. The line-of-sight (LOS) radial velocity (RV) shifts from long-term spectroscopic monitoring can be used to test the BBH hypothesis. We have selected a sample of 399 quasars with offset broad H-beta lines from the SDSS DR7 quasar catalog, and have conducted second-epoch optical spectroscopy for 50 of them. Combined with the existing SDSS spectra, the new observations enable us to constrain the LOS RV shifts of broad H-beta lines with a rest-frame baseline of a few years to nearly a decade. Using cross-correlation analysis, we detect significant (99% confidence) radial accelerations in the broad H-beta lines in 24 of the 50 objects. We suggest that 9 of the 24 detections are sub-pc BBH candidates, which show consistent velocity shifts independently measured from a second broad line (either H-alpha or Mg II) without significant changes in the broad-line profiles. Combining the results on the general quasar population studied in Paper I, we find a tentative anti-correlation between the velocity offset in the first-epoch spectrum and the average acceleration between two epochs, which could be explained by orbital phase modulation when the time separation between two epochs is a non-negligible fraction of the orbital period of the motion causing the line displacement. We discuss the implications of our results for the identification of sub-pc BBH candidates in offset-line quasars and for the constraints on their frequency and orbital parameters. [Abridged]
description: 23 pages, 18 figures, ApJ in press
Yang-Mills theories with an arbitrary number of compactified extra dimensions
Creators: name: López-Osorio, M. A.
name: Martínez-Pascual, E.
name: Novales-Sánchez, H.
name: Toscano, J. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The well-known Yang-Mills theory with one $ S^{1} / Z_{2}$ universal extra dimension (UED) is generalized to an arbitrary number of spatial extra dimensions through a novel compactification scheme. In this paper, the Riemannian flat based manifold under consideration contains $ n $ spatial extra dimensions defined by $ n $ copies of the orbifold $ S^{1} / Z_{2}$. In this approach, we present the gauge structure and the mass spectrum of the effective four-dimensional theory. We introduce the concept of standard and nonstandard gauge transformations of the effective theory, and explicitly identify the emergence of massive vector fields in the same number as massless ('pseudo-Goldstone') scalars in the compactified theory, verifying that a Higgs-like mechanism operates in the compactification process. It is found that, in contrast with the one UED scenario, in cases with two or more UEDs there emerge massive scalar fields. Besides, at phase-space level, the Hamiltonian analysis yields that the higher-dimensional and compactified theories are classically equivalent using the fundamental concept of canonical transformation. This work lays the ground for a wider study on these theories concerning their quantization and predictive power at the level of quantum fluctuations.
description: Minor changes in the Introduction, and some typos corrected
On reaching the adiabatic limit in multi-field inflation
Creators: name: Renaux-Petel, Sébastien
name: Turzynski, Krzysztof
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We calculate the scalar spectral index $n_s$ and the tensor-to-scalar ratio $r$ in a class of recently proposed two-field no-scale inflationary models in supergravity. We show that, in order to obtain correct predictions, it is crucial to take into account the coupling between the curvature and the isocurvature perturbations induced by the noncanonical form of the kinetic terms. This coupling enhances the curvature perturbation and suppresses the resulting tensor-to-scalar ratio to the per mille level even for values of the slow-roll parameter $ε\sim 0.01$. Beyond these particular models, we emphasise that multifield models of inflation are a priori not predictive, unless one supplies a prescription for the post-inflationary era, or an adiabatic limit is reached before the end of inflation. We examine the conditions that enabled us to actually derive predictions in the models under study, by analysing the various contributions to the effective isocurvature mass in general two-field inflationary models. In particular, we point out a universal geometrical contribution that is important at the end of inflation, and which can be directly extracted from the inflationary Lagrangian, independently of a specific trajectory. Eventually, we point out that spectator fields can lead to oscillatory features in the time-dependent power spectra at the end of inflation. We demonstrate how these features can be model semi-analytically as well as the theoretical uncertainties they can entail.
description: 26 pages. 13 figures. One additional author. Substantially reworked and extended
Scientific Roadmap and Innovation Management Evaluation
Creators: name: Sideris Anargiros
Publisher: name: Zenodo
Year: 2021
Subjects: Innovation
Innovation Radar
Innovation Roadmap

description: This report presents the final updates and results for the Scientific and Innovation roadmap of the Horizon 2020 (H2020) research and innovation project SPHINX. The document describes the set of actions that were carried out within SPHINX necessary to achieve the SPHINX vision, and guidelines to assist the cyber security industry and scientists to address externalities in order to improve innovation and competitiveness which will, in turn, have a significant impact on the main beneficiaries of SPHINX, the healthcare sector. It also describes the different pathways that were taken by the SPHINX Consortium to ensure that project innovations are captured, secured and promoted.
A poset view of the major index
Creators: name: Ehrenborg, Richard
name: Readdy, Margaret
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: Primary 06A07, Secondary 05A05, 52B05

description: We introduce the Major MacMahon map and show how this map interacts with the pyramid and bipyramid operators. When the Major MacMahon map is applied to the ab-index of a simplicial poset, it yields the q-analogue of n! times the h-polynomial of the poset. Applying the map to the Boolean algebra gives the distribution of the major index on the symmetric group, a seminal result due to MacMahon. Similarly, when applied to the cross-polytope we obtain the distribution of one of the major indexes on signed permutations due to Reiner.
description: 13 pages, 1 figure. Final version
Non-Abelian String and Particle Braiding in Topological Order: Modular SL(3,Z) Representation and 3+1D Twisted Gauge Theory
Creators: name: Wang, Juven
name: Wen, Xiao-Gang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Algebra (math.QA)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: String and particle braiding statistics are examined in a class of topological orders described by discrete gauge theories with a gauge group $G$ and a 4-cocycle twist $ω_4$ of $G$'s cohomology group $\mathcal{H}^4(G,\mathbb{R}/\mathbb{Z})$ in 3 dimensional space and 1 dimensional time (3+1D). We establish the topological spin and the spin-statistics relation for the closed strings, and their multi-string braiding statistics. The 3+1D twisted gauge theory can be characterized by a representation of a modular transformation group SL$(3,\mathbb{Z})$. We express the SL$(3,\mathbb{Z})$ generators $\mathsf{S}^{xyz}$ and $\mathsf{T}^{xy}$ in terms of the gauge group $G$ and the 4-cocycle $ω_4$. As we compactify one of the spatial directions $z$ into a compact circle with a gauge flux $b$ inserted, we can use the generators $\mathsf{S}^{xy}$ and $\mathsf{T}^{xy}$ of an SL$(2,\mathbb{Z})$ subgroup to study the dimensional reduction of the 3D topological order $\mathcal{C}^{3\text{D}}$ to a direct sum of degenerate states of 2D topological orders $\mathcal{C}_b^{2\text{D}}$ in different flux $b$ sectors: $\mathcal{C}^{3\text{D}} = \oplus_b \mathcal{C}_b^{2\text{D}}$. The 2D topological orders $\mathcal{C}_b^{2\text{D}}$ are described by 2D gauge theories of the group $G$ twisted by the 3-cocycles $ω_{3(b)}$, dimensionally reduced from the 4-cocycle $ω_4$. We show that the SL$(2,\mathbb{Z})$ generators, $\mathsf{S}^{xy}$ and $\mathsf{T}^{xy}$, fully encode a particular type of three-string braiding statistics with a pattern that is the connected sum of two Hopf links. With certain 4-cocycle twists, we discover that, by threading a third string through two-string unlink into three-string Hopf-link configuration, Abelian two-string braiding statistics is promoted to non-Abelian three-string braiding statistics.
description: 36 pages, many figures, 17 tables. v3: Accepted by Phys. Rev. B. Add acknowledgements to Louis H. Kauffman
Innovación PCA.xlsx
Creators: name: Enriquez, Hugo
Publisher: name: figshare
Year: 2022
Subjects: Innovation management

description: Principal Component Analysis (PCA) within a set of Likert scales based on a survey for entrepreneurs and managers of meat companies. The mains results are: to remove 3 components out of 8 that were initially proposed. As findings: Two factors are generated, where the main components are ADEXP (acquisition of cutting edge tech), CINPRODS (collaboration between companies to innovate in products that are exportable) INPRODEXP (Innovation of exportable products). AD1 (Acquisition of machinery) and AD2 (Acquisition of software).
HUVN Investiga nº 12
Creators: name: Flores, Encarnación Gonzalez
name: Águila, Mª Mar Rodríguez Del
name: Alba-Ruiz, Rubén
name: Gualda, Jaqueline
Publisher: name: Zenodo
Year: 2023
Subjects: Investigación
Newsletter
Noticias
Financiación
Premios
Ensayos Clínicos
Publicaciones
Indicadores bibliométricos

description: La Unidad de Gestión y Apoyo a la Investigación del Hospital Universitario Virgen de las Nieves de Granada publica el Newsletter mensual número 12 correspondiente a febrero de 2023. La newsletter contiene información sobre la producción científica, proyectos, cursos, ensayos clínicos y noticias de interés del el Hospital Universitario Virgen de las Nieves de Granada. Según datos provisionales elaborados por la herramienta Impactia de la Biblioteca Virtual, el hospital ha alcanzado una puntuación de 1.891, 646 en factor de impacto, que es superior a la obtenida tanto en 2019 como en 2020, pero ligeramente inferior a los 2.054,351 puntos del año pasado. Estos resultados no son definitivos pues la evaluación se ha realizado a 20 de diciembre y aún faltan por incluir publicaciones. Aún así, el hospital cumple el objetivo al tener un factor de impacto superior a la media de los tres años anteriores. Se han evaluado los objetivos de investigación de las unidades, obteniendo que de los 41 objetivos propuestos se han cumplido completamente un 71% y parcialmente un 19%; el 10% restante se ha dado por no cumplido. En esta ocasión como artículo del mes, debido al crecimiento de las herramientas basadas en inteligencia artificial (IA) y el
 impacto generado en los últimos meses, en especial con ChatGPT, hacemos una pequeña revisión de las publicaciones generadas en torno a esta herramienta en la revista Nature. Como "Recurso del mes" se ha incluido Jamovi, herramienta para el análisis estadístico de datos mediante menús
 basada en R. https://www.huvn.es/investigacion/newsletter_huvn_investiga
description: La revista contiene información sobre la producción científica, proyectos, cursos, ensayos clínicos y noticias de interés del el Hospital Universitario Virgen de las Nieves de Granada. Se trata de una revista digital mensual que proporciona contenido para ejecutivos de hospitales y sistemas de salud. El boletín está disponible en formato de archivo Adobe PDF y se puede descargar desde el sitio web del hospital.
A Three-Loop Model of Neutrino Mass with Dark Matter
Creators: name: Ahriche, Amine
name: Chen, Chian-Shu
name: McDonald, Kristian L.
name: Nasri, Salah
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a model in which the origin of neutrino mass is dependent on the existence of dark matter. Neutrinos acquire mass at the three-loop level and the dark matter is the neutral component of a fermion triplet. We show that experimental constraints are satisfied and that the dark matter can be tested in future direct-detection experiments. Furthermore, the model predicts a charged scalar that can be within reach of collider experiments like the LHC.
description: v2 PRD version (revtex, 9 pages, 5 figures)
Primary hypertension, anti-hypertensive medications and the risk of severe COVID-19 in UK Biobank.
Creators: name: Pavey, Holly
name: Kulkarni, Spoorthy
name: Wood, Angela
name: Ben-Shlomo, Yoav
name: Sever, Peter
name: McEniery, Carmel
name: Wilkinson, Ian
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research Article
Medicine and health sciences

description: Acknowledgements: This research has been conducted using the UK Biobank Resource (45885).
description: Funder: Cambridge BHF CRE non-clinical PhD Studentship
description: Funder: Imperial College London Biomedical Research Centre Award
description: Funder: NIHR Applied Research Collaboration (ARC) West
description: Hypertension appears to be one of the commonest comorbidities in COVID-19 patients, although whether hypertensive individuals have a higher risk of severe COVID-19 compared with non-hypertensives is unclear. It is also unclear whether the absolute level of systolic blood pressure, or the type of anti-hypertensive medication is related to this risk. Analyses were conducted using data from the UK Biobank and linked health records. Logistic regression models were fitted to assess the impact of hypertension, systolic blood pressure (SBP) and medications on the risk of severe COVID-19. 16,134 individuals tested positive for severe acute respiratory syndrome-coronavirus, 22% (n = 3,584) developed severe COVID-19 and 40% (n = 6,517) were hypertensive. Hypertension was associated with 22% higher odds of severe COVID-19 (Odds ratio (OR) 1.22; 95% confidence interval (CI) 1.12, 1.33), compared with normotension after adjusting for confounding variables. In those taking anti-hypertensive medications, elevated SBP showed a dose-response relationship with severe COVID-19 (150-159mmHg versus 120-129mmHg (OR 1.91; 95% CI 1.44, 2.53), >180+mmHg versus 120-129mmHg (OR 1.93; 95% CI 1.06, 3.51)). SBP <120mmHg was associated with greater odds of severe COVID-19 (OR 1.40; 95% CI 1.11, 1.78). Angiotensin-converting enzyme inhibitors or angiotensin-II receptor blockers were not associated with altered risk of severe COVID-19. Hypertension is an important risk factor for COVID-19. A better understanding of the underlying mechanisms is warranted in case of more severe strains or other viruses in the future.
Enterprise Application Integration - Ein Modell zur Bewertung von IT-Investitionen in die Integration von Anwendungssystemen
Creators: name: Heinrich, Bernd
name: Fridgen, Michael
Publisher: name: Universität Regensburg
Year: 2005
Subjects: subject: Anwendungssystemintegration, Enterprise Application Integration (EAI), Investitionsentscheidung
subject: 330 Wirtschaft

description: In der Arbeit werden quantitative Kriterien zur Unterstützung von EAIInvestitionsentscheidungen abgeleitet. Diese Kriterien berücksichtigen praktische Zielsetzungen und Rahmenbedingungen, wie die Reintegration bestehender „Anwendungsinseln“, die Ausgliederung von Geschäftsfunktionen oder das Betreiben großer, organisch gewachsener Anwendungslandschaften. Somit soll ein Beitrag zur ökonomischen Beurteilung einer EAI-Lösung unter Berücksichtigung der spezifischen Anforderungen eines Unternehmens (im Vergleich zur Übertragung von „best practice“-Ansätzen) geleistet werden.
Gravity imager design review
Creators: name: Antoni-Micollier, Laura
name: Lautier-Gaud, Jean
Publisher: name: Zenodo
Year: 2018
Subjects: gravity imager
MEMS gravimeters
Quantum gravimeter
Etna volcano

description: The gravity imager, which will be developed under NEWTON-g and field-tested at Mt. Etna volcano, is composed by an array of microelectromechanical system (MEMS) pixels and an absolute quantum gravimeter (AQG). The main aim of the present document is to define the final configuration of the gravity imager, taking into account the environmental constraints and the gravimetric signature of volcanic processes highlighted in Deliverable 4.1, especially in terms of magnitude, timescale, detection zone and probability of occurrence of these processes.
title: Ein meta-hybrides Empfehlungssystem für Filme
Creators: name: Dimitrov, Krasen
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: Empfehlungsgenerierung, inhaltsbasiertes Filtern, kollaboratives Filtern, hybride Empfehlungssysteme, Filmähnlichkeit, Vektoren
subject: 020 Bibliotheks- und Informationswissenschaft

description: Im Rahmen dieser Arbeit wurden die theoretischen Grundlagen und Ansätze der Empfehlungsgenerierung in Verbindung zu kleinen und mittelgroßen Filmplattformen behandelt. Durch den Entwurf eines Systemmodells für Empfehlungsgenerierung von Filmen am Beispiel von der Filmplattform critic.de wurde ein praktischer Bezug zu der daraus entstehenden Problematik hergestellt. Ein meta-hybrides System bestehend aus content-based und collaborative filtering wurde als Lösung für die Kaltstartproblematik, welche besonders Empfehlungssysteme mit wenigen Benutzern betrifft, vor-geschlagen. Die anschließende Implementierung des Filmähnlich-keitssystems validierte das vorgeschlagene Datenmodell zur Repräsentation von Filmen und den Ähnlichkeitsalgorithmus.
description: This thesis discusses the theoretical groundwork and scientific approaches to recommender systems in the context of small and medium-sized movie portals. In the first part of this work the reader is presented with a brief overview of the said systems. In the second part through the design of a system model for movie recommendation on the basis of the movie portal critic.de a practical reference to the resulting problems could be established. A meta-hybrid system consisting of content-based and collaborative filtering is presented as a solution to the cold start problem, which most of all affects systems with a small number of users. The concluding implementation of the movie similarity subsystem validates the proposed data model for the representation of movies and the similarity algorithm.
Terminality implies non-signalling
Creators: name: Coecke, Bob
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Logic in Computer Science (cs.LO)
subject: Category Theory (math.CT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: A 'process theory' is any theory of systems and processes which admits sequential and parallel composition. `Terminality' unifies normalisation of pure states, trace-preservation of CP-maps, and adding up to identity of positive operators in quantum theory, and generalises this to arbitrary process theories. We show that terminality and non-signalling coincide in any process theory, provided one makes causal structure explicit. In fact, making causal structure explicit is necessary to even make sense of non-signalling in process theories. We conclude that because of its much simpler mathematical form, terminality should be taken to be a more fundamental notion than non-signalling.
description: In Proceedings QPL 2014, arXiv:1412.8102
Jan Sowa: Fantomowe ciało króla. Peryferyjne zmagania z nowoczesną formą. Kraków 2011
Creators: name: Korsak, Maciej
Publisher: name: Świat Idei i Polityki
Year: 2012

description: Świat Idei i Polityki, Tom 11 (2012): Świat Idei i Polityki
Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants
Creators: name: Klinker, J. F.
name: Schwaner, I.
name: Offermanns, S.
name: Hagelüken, A.
name: Seifert, Roland
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Bucladesine/pharmacology
subject: Calcium/metabolism
subject: Cell Differentiation/drug effects
subject: Complement C5a/pharmacology
subject: Enzyme Activation
subject: GTP Phosphohydrolases/metabolism
subject: Guanosine 5'-O-(3-Thiotriphosphate)/metabolism
subject: Guanosine Triphosphate/metabolism
subject: Humans
subject: Hydrolysis
subject: Leukemia/pathology
subject: Leukotriene B4/pharmacology
subject: N-Formylmethionine Leucyl-Phenylalanine/pharmacology
subject: Signal Transduction
subject: Tumor Cells, Cultured

description: Dibutyryl cAMP-differentiated HL-60 human leukemia cells possess receptors for the chemoattractants N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), C5a and leukotriene B4 (LTB4). We compared the effects of these chemoattractants in HL-60 membranes and in intact HL-60 cells. fMLP, C5a and LTB4 stimulated GTP hydrolysis and guanosine 5'-O-[3-thio]triphosphate (GTP[gamma S]) binding in HL-60 membranes with similar effectiveness and in a pertussis toxin (PTX)-sensitive manner. They also stimulated photolabeling of the alpha-subunits of the guanine nucleotide-binding proteins (G-proteins), Gi2 and Gi3 with similar effectiveness. Chloride salts of monovalent cations differentially enhanced and inhibited chemoattractant-induced GTP hydrolyses. C5a was less effective than fMLP in enhancing cholera toxin-catalysed ADP-ribosylation of Gi alpha 2 and Gi alpha 3, and LTB4 was ineffective. fMLP was more effective than C5a and LTB4 in stimulating Ca2+ influx in HL-60 cells. C5a- and LTB4-induced rises in cytosolic Ca2+ concentration ([Ca2+]i) were PTX-sensitive, whereas the effect of fMLP was partially PTX-insensitive. LTB4-induced rises in [Ca2+]i were more sensitive towards homologous desensitization than those induced by C5a, and the effect of fMLP was resistant in this regard. C5a was considerably less effective than fMLP in activating superoxide anion formation and azurophilic granule release, and LTB4 was ineffective. Our data suggest that fMLP, C5a and LTB4 effectively activate the G-proteins, Gi2 and Gi3, in HL-60 cells and that fMLP may additionally activate PTX-insensitive G-proteins. fMLP, C5a and LTB4 are full, partial and incomplete secretagogues, respectively, and these differences may be due to differences in homologous receptor desensitization and qualitative Gi-protein activation.
Characterization of Colloidal Drug Carriers
Creators: name: Blunk, Torsten
name: Mak, E.
name: Müller, R. H.
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 615 Pharmazie

description: Hydrophobic interaction chromatography (HIC) is presented as a suitable method to determine the surface hydrophobicity of colloidal drug carriers. The experimental design is described in great detail. Results obtained with surface-modified polystyrene particles as model carriers and parenteral fat emulsions are discussed as examples. HIC was able to distinguish between particles chemically modified by the introduction of functional groups. Polystyrene particles of various size were surface-modified by adsorption of the block-polymer Poloxamine 908. HIC distinguished between the hydrophobicities of these adsorption layers. The measured surface hydrophobicities of particles and fat emulsions were well in agreement with the in vivo organ distribution data obtained after i. v. injection of the carriers.
Adam Gwiazda: Demograficzne wyzwania XXI wieku. Implikacje dla polityki międzynarodowej, Gdynia 2011
Creators: name: Cieślik-Florczyk, Małgorzata
Publisher: name: Świat Idei i Polityki
Year: 2012

description: Świat Idei i Polityki, Tom 11 (2012): Świat Idei i Polityki
Lazy Model Expansion: Interleaving Grounding with Search
Creators: name: De Cat, Broes
name: Denecker, Marc
name: Stuckey, Peter
name: Bruynooghe, Maurice
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: Finding satisfying assignments for the variables involved in a set of constraints can be cast as a (bounded) model generation problem: search for (bounded) models of a theory in some logic. The state-of-the-art approach for bounded model generation for rich knowledge representation languages, like ASP, FO(.) and Zinc, is ground-and-solve: reduce the theory to a ground or propositional one and apply a search algorithm to the resulting theory. An important bottleneck is the blowup of the size of the theory caused by the reduction phase. Lazily grounding the theory during search is a way to overcome this bottleneck. We present a theoretical framework and an implementation in the context of the FO(.) knowledge representation language. Instead of grounding all parts of a theory, justifications are derived for some parts of it. Given a partial assignment for the grounded part of the theory and valid justifications for the formulas of the non-grounded part, the justifications provide a recipe to construct a complete assignment that satisfies the non-grounded part. When a justification for a particular formula becomes invalid during search, a new one is derived; if that fails, the formula is split in a part to be grounded and a part that can be justified. The theoretical framework captures existing approaches for tackling the grounding bottleneck such as lazy clause generation and grounding-on-the-fly, and presents a generalization of the 2-watched literal scheme. We present an algorithm for lazy model expansion and integrate it in a model generator for FO(ID), a language extending first-order logic with inductive definitions. The algorithm is implemented as part of the state-of-the-art FO(ID) Knowledge-Base System IDP. Experimental results illustrate the power and generality of the approach.
Some taste substances are direct activators of G-proteins
Creators: name: Naim, M.
name: Seifert, Roland
name: Nürnberg, B.
name: Grünbaum, L.
name: Schultz, Günter
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Animals
subject: Cattle
subject: Enzyme Activation
subject: GTP Phosphohydrolases/metabolism
subject: GTP-Binding Proteins/metabolism
subject: Peptides
subject: Phosphatidylcholines
subject: Phospholipids/pharmacology
subject: Sweetening Agents/pharmacology
subject: Taste/drug effects
subject: Wasp Venoms/pharmacology

description: Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.
A Study of Entanglement in a Categorical Framework of Natural Language
Creators: name: Kartsaklis, Dimitri
name: Sadrzadeh, Mehrnoosh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Category Theory (math.CT)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In both quantum mechanics and corpus linguistics based on vector spaces, the notion of entanglement provides a means for the various subsystems to communicate with each other. In this paper we examine a number of implementations of the categorical framework of Coecke, Sadrzadeh and Clark (2010) for natural language, from an entanglement perspective. Specifically, our goal is to better understand in what way the level of entanglement of the relational tensors (or the lack of it) affects the compositional structures in practical situations. Our findings reveal that a number of proposals for verb construction lead to almost separable tensors, a fact that considerably simplifies the interactions between the words. We examine the ramifications of this fact, and we show that the use of Frobenius algebras mitigates the potential problems to a great extent. Finally, we briefly examine a machine learning method that creates verb tensors exhibiting a sufficient level of entanglement.
description: In Proceedings QPL 2014, arXiv:1412.8102
Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis
Creators: name: Blunk, Torsten
name: Hochstrasser, D. F.
name: Sanchez, J. C.
name: Müller, B. W.
name: Müller, R. H.
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 615 Pharmazie
subject: Adsorption
subject: Apolipoproteins/analysis
subject: Blood Proteins/metabolism
subject: Chemistry, Physical
subject: Colloids
subject: Complement Factor B/analysis
subject: Drug Carriers
subject: Electrophoresis, Gel, Two-Dimensional
subject: Fibrinogen/analysis
subject: Humans
subject: Injections, Intravenous
subject: Microspheres
subject: Physicochemical Phenomena
subject: Polystyrenes/chemistry
subject: Transferrin/analysis

description: Targeting to specific sites of the body via colloidal carriers is sought in order to reduce drug side effects. The adsorption of plasma proteins on intravenously injected particles is regarded as the key factor in explaining their organ distribution: total bound protein, or, more likely, the presence of specific proteins and their conformation, are expected to influence macrophage uptake. Polystyrene beads, 60 nm in diameter, were used as model carriers; their surface was differentially modified by adsorption of increasingly hydrophilic block copolymers, poloxamers 184, 188 and 407. After incubation in plasma, the patterns of protein adsorption onto coated beads were analyzed by high-resolution two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). The behavior of some representative proteins was monitored, including albumin, fibrinogen, IgG, factor B and the apolipoproteins, A-I, A-IV, C-III, E and J. The more hydrophobic the particles, the larger the total amount of bound protein. However, this correlation was not valid for all of the analyzed protein species, which proves that it is insufficient to look only at physicochemical data to predict organ distribution. On the contrary, it is essential to use 2-D PAGE to establish the correlation between adsorbed proteins and carrier behavior in vivo.
Special Killing forms on toric Sasaki-Einstein manifolds
Creators: name: Slesar, Vladimir
name: Visinescu, Mihai
name: Vilcu, Gabriel Eduard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we study the interplay between complex coordinates on the Calabi-Yau metric cone and the special Killing forms on the toric Sasaki-Einstein manifold. In the general case we give a procedure to locally construct the special Killing forms. In the final part we exemplify the general scheme in the case of the $5-$dimensional $Y^{p,q}$ spaces, identifying the additional special Killing 2-forms which were previously obtained by the second author of the present paper, but with a different method, in [Mod. Phys. Lett. A 27 (2012) 1250217].
description: 15 pages, version accepted for publication in Physica Scripta
Maximum therapeutic effect of glioma treatment by radio-frequency electric field
Creators: name: Iomin, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cell Behavior (q-bio.CB)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: Medical Physics (physics.med-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: An influence of a radio-frequency electric field on glioma - brain cancer development is considered. A specific task emerging here is whether this new medical technology is effective against invasive cells with a high motility, when switching between migrating and proliferating phenotypes takes place. This therapeutic effect is studied in the framework of a continuous time random walk. It is shown that the migration proliferation dichotomy of cancer cells leads to the weakening of the electric field treatment.
description: Published in Chaos, Solitons & Fractals (2014)
Gaussian fluctuations of Young diagrams and structure constants of Jack characters
Creators: name: Dołęga, Maciej
name: Féray, Valentin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 60C05, 05E05 (secondary:60B20)

description: In this paper, we consider a deformation of Plancherel measure linked to Jack polynomials. Our main result is the description of the first and second-order asymptotics of the bulk of a random Young diagram under this distribution, which extends celebrated results of Vershik-Kerov and Logan-Shepp (for the first order asymptotics) and Kerov (for the second order asymptotics). This gives more evidence of the connection with Gaussian $β$-ensemble, already suggested by some work of Matsumoto. Our main tool is a polynomiality result for the structure constant of some quantities that we call Jack characters, recently introduced by Lassalle. We believe that this result is also interested in itself and we give several other applications of it.
description: 71 pages. Minor modifications from version 1. An extended abstract of this work, with significantly fewer results and a different title, is available as arXiv:1201.1806
Belief propagation in monoidal categories
Creators: name: Morton, Jason
Publisher: name: arXiv
Year: 2014
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics

description: We discuss a categorical version of the celebrated belief propagation algorithm. This provides a way to prove that some algorithms which are known or suspected to be analogous, are actually identical when formulated generically. It also highlights the computational point of view in monoidal categories.
description: In Proceedings QPL 2014, arXiv:1412.8102
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions
Creators: name: Wenzel-Seifert, K.
name: Schächtele, C.
name: Seifert, Roland
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Carbazoles/pharmacology
subject: Enzyme Activation
subject: Humans
subject: Indoles/pharmacology
subject: Isoenzymes/metabolism
subject: Maleimides/pharmacology
subject: Muramidase/metabolism
subject: N-Formylmethionine Leucyl-Phenylalanine/pharmacology
subject: Neutrophils/enzymology
subject: Protein Kinase C/metabolism
subject: Respiratory Burst/drug effects
subject: Superoxides/metabolism
subject: Tetradecanoylphorbol Acetate/pharmacology

description: The role of protein kinase C (PKC) isoenzymes in the regulation of cell functions is largely unknown. We studied the effects of 2-(1H-indol-3-yl)-3- [1-(3-dimethylaminopropyl)-1H-indol-3-yl]-maleinimide (Gö 6850), a selective inhibitor of c- and n-PKC isoenzymes, and 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2 ,3- a]pyrrolo[3, 4-c]-carbazole (Gö 6976), an inhibitor of c-PKC isoenzymes, on various human neutrophil functions. Gö 6850 inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-, 1,2-dicaprylyl- glycerol- and chemotactic peptide-induced superoxide anion formation with half-maximal effects at 100 nM, 240 nM and 850 nM, respectively. Gö 6850 reverted PMA-mediated inhibition of chemotactic peptide-induced rises in cytosolic Ca2+ concentration with a half-maximal effect at 480 nM. Gö 6850 (1 microM) inhibited PMA-induced lysozyme release by 55%. Gö 6976 had no effect on the parameters studied. Our data suggest the following: (1) n- Rather than c-PKC isoenzymes are involved in the regulation of various human neutrophil functions. (2) Different n-PKC isoenzymes may mediate activation of NADPH oxidase by various stimuli. (3) Different n-PKC isoenzymes may be involved in the mediation of the effects of PMA on various cell functions.
Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores
Creators: name: Seifert, Roland
name: Grünbaum, L.
name: Schultz, Günter
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Adenosine Diphosphate Ribose/metabolism
subject: Calcium/metabolism
subject: Cell Line
subject: GTP-Binding Proteins/metabolism
subject: Histamine/pharmacology
subject: Histamine Agonists/pharmacology
subject: Humans
subject: Imidazoles/pharmacology
subject: Monocytes/metabolism
subject: N-Formylmethionine Leucyl-Phenylalanine/pharmacology
subject: Oxygen Consumption/drug effects
subject: Pertussis Toxin
subject: Platelet Aggregation Inhibitors/pharmacology
subject: Receptors, Histamine H1/metabolism
subject: Virulence Factors, Bordetella/pharmacology

description: The results of binding studies suggest the presence of histamine H1-receptors in human monocytes, but it is not known whether these receptors are functionally active. This prompted us to study the effects of histamine (HA) on cytosolic Ca2+ concentration ([Ca2+]i) and superoxide anion (O2-) formation in HL-60 cells differentiated towards monocytes with 1 alpha,25-dihydroxycholecalciferol. In HL-60 monocytes, HA increased [Ca2+]i with a half-maximal effect at 8 microM and a maximum at 30-100 microM. Pertussis toxin (PTX) partially inhibited the stimulatory effects of HA on [Ca2+]i. Betahistine, a weak partial H1-receptor agonist, also increased [Ca2+]i, whereas H2- and H3-receptor agonists were ineffective. H1- but not H2- and H3-receptor antagonists inhibited HA-induced rises in [Ca2+]i. HA-induced rises in [Ca2+]i were desensitized in a homologous manner and were also inhibited by the activator of protein kinase C, 4 beta-phorbol 12-myristate 13-acetate. Various protein kinase C inhibitors did not interfere with homologous desensitization. The stimulatory effects of HA on [Ca2+]i were completely dependent on the presence of extracellular Ca2+ and were inhibited by the blocker of non-selective cation (NSC) channels, 1-(beta-[3-(4-methoxyphenyl)propoxyl]-4-methoxyphenethyl)-1 H-imidazole hydrochloride (SK & F 96365). HA was much less effective than the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), to induce rises in [Ca2+]i. Unlike fMLP, HA did not activate O2- formation.(ABSTRACT TRUNCATED AT 250 WORDS)
Effect of isoelectronic doping on honeycomb lattice iridate A_2IrO_3
Creators: name: Manni, S.
name: Choi, Sungkyun
name: Mazin, I. I.
name: Coldea, R.
name: Altmeyer, Michaela
name: Jeschke, Harald O.
name: Valenti, Roser
name: Gegenwart, P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have investigated experimentally and theoretically the series (Na$_{1-x}$Li$_{x}$)$_{2}$IrO$_{3}$. Contrary to what has been believed so far, only for $x\leq0.25$ the system forms uniform solid solutions. For larger Li content, as evidenced by powder X-ray diffraction, scanning electron microscopy and density functional theory calculations, the system shows a miscibility gap and a phase separation into an ordered Na$_{3}$LiIr$_2$O$_{6}$ phase with alternating Na$_3$ and LiIr$_2$O$_6$ planes, and a Li-rich phase close to pure Li$_{2}$IrO$_{3}$. For $x\leq 0.25$ we observe (1) an increase of $c/a$ with Li doping up to $x=0.25$, despite the fact that $c/a$ in pure Li$_{2}$IrO$_{3}$ is smaller than in Na$_{2}$IrO$_{3}$, and (2) a gradual reduction of the antiferromagnetic ordering temperature $T_{N}$ and ordered moment. The previously proposed magnetic quantum phase transition at $x\approx 0.7$ may occur in a multiphase region and its nature needs to be re-evaluated.
description: 8 pages, 9 figures including supplemental information
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins
Creators: name: Hagelüken, A.
name: Grünbaum, L.
name: Nürnberg, B.
name: Harhammer, R.
name: Schunack, W.
name: Seifert, Roland
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Adrenergic beta-Antagonists/pharmacology
subject: Anesthetics, Local/pharmacology
subject: Cell Line
subject: Cell Membrane/drug effects
subject: GTP-Binding Proteins/metabolism
subject: Humans
subject: Lipid Metabolism
subject: Pertussis Toxin
subject: Propranolol/pharmacology
subject: Tetracaine/pharmacology
subject: Virulence Factors, Bordetella/pharmacology

description: We studied the effects of various beta-adrenoceptor (beta AR) antagonists and local anesthetics (LAs), i.e. substances possessing one basic and one lipophilic domain each, on activation of regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). In membranes of differentiated HL-60 cells, propranolol activated high-affinity GTP hydrolysis with a half-maximal effect at 0.19 mM and a maximum at 1 mM. There was a close correlation between the log Q values (logarithm of the octanol: water partition coefficient) of beta AR antagonists and the logarithm of their effectiveness at activating GTPase (EC 3.6.1.-) in HL-60 membranes. The lipophilic LA, tetracaine, was also an effective activator of GTPase in HL-60 membranes, whereas more hydrophilic LAs were less stimulatory (bupivacaine and lidocaine) or even inhibitory (procaine). Propranolol and tetracaine also stimulated binding of guanosine 5'-O-[3-thio]triphosphate (GTP[gamma S]) to HL-60 membranes, but their stimulatory effects on GTP[gamma S] binding were smaller than on GTP hydrolysis. The stimulatory effects of propranolol and tetracaine on GTPase and GTP[gamma S] binding were inhibited by pertussis toxin. Propranolol and tetracaine effectively activated GTP hydrolysis of a reconstituted mixture of bovine brain Gi/Go-proteins, but the concentrations of substances needed for GTPase activation were higher than in HL-60 membranes. Procaine showed stimulatory effects on the GTPase of Gi/Go-proteins. Our data show that beta AR antagonists and LAs activate pertussis toxin-sensitive G-proteins, presumably through interaction with the C-terminus of their alpha-subunits. Apparently, the lipophilic domain of beta AR antagonists and LAs is more important for G-protein activation than the basic domain. We discuss the possibility that activation of nucleoside diphosphate kinase by beta AR antagonists and LAs contributes to their stimulatory effects on GTP hydrolysis in HL-60 membranes.