Association of shift-work, daytime napping, and nighttime sleep with cancer incidence and cancer-caused mortality in Dongfeng-tongji cohort study
Creators: name: Yansen Bai
name: Xiaoliang Li
name: Wang, Ke
name: Chen, Shi
name: Suhan Wang
name: Zhuowang Chen
name: Xiulong Wu
name: Wenshan Fu
name: Wei, Sheng
name: Yuan, Jing
name: Yao, Ping
name: Xiaoping Miao
name: Xiaomin Zhang
name: Meian He
name: Handong Yang
name: Tangchun Wu
name: Guo, Huan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: Computational Biology

description: <b>Background:</b> Few studies investigated the combined effects of night-shift work, daytime napping, and nighttime sleep on cancer incidence and mortality. <b>Methods:</b> A total of 25,377 participants were included in this study. Information on sleep habits, cancer incidences, and mortalities were collected. Cox proportional hazards models were used to calculate the adjusted hazard ratios and 95% confidence intervals (HRs, 95%CIs). <b>Results:</b> Male subjects experienced ≥20 years of night-shift work, or without daytime napping had an increased risk of cancer, when compared with males who did not have night-shift work or napped for 1–30 min [HR (95%CI) = 1.27 (1.01–1.59) and 2.03 (1.01–4.13), respectively]. Nighttime sleep for ≥10 h was associated with a separate 40% and 59% increased risk of cancer [HR (95%CI) = 1.40 (1.04–1.88)] and cancer-caused mortality [HR (95%CI) = 1.59 (1.01–2.49)] than sleep for 7–8 h/night. Combined effects of three sleep habits were further identified. Male participants with at least two above risk sleep habits had a 43% increased risk of cancer [HR (95%CI) = 1.43 (1.07–2.01)] and a 2.07-fold increased cancer-caused mortality [HR (95%CI) = 2.07 (1.25–3.29)] than those who did not have any above risk sleep habits. However, no significant associations were observed among women. <b>Conclusions:</b> Long night-shift work history, without daytime napping, and long nighttime sleep duration were independently and jointly associated with higher cancer incidence among males.KEY MESSAGESNight-shift work of ≥20 years, without napping, and nighttime sleep of ≥10 h were associated with increased cancer incidence.Nighttime sleep ≥10 h was associated with a 2.07-fold increased cancer-caused mortality among males.Combined effects of night-shift work ≥20 years, without napping, and nighttime sleep ≥10 h on increasing cancer incidence were existed among males. Night-shift work of ≥20 years, without napping, and nighttime sleep of ≥10 h were associated with increased cancer incidence. Nighttime sleep ≥10 h was associated with a 2.07-fold increased cancer-caused mortality among males. Combined effects of night-shift work ≥20 years, without napping, and nighttime sleep ≥10 h on increasing cancer incidence were existed among males.