cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanisms of Zoonotic Severe Acute Respiratory Syndrome Coronavirus Host Range Expansion in Human Airway Epithelium
Creators: name: Donaldson, Eric
name: Sheahan, Timothy
name: Corti, Davide
name: Rockx, Barry
name: Sims, Amy
name: Baric, Ralph
name: Pickles, Raymond
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) emerged and caused over 8,000 human cases of infection and more than 700 deaths worldwide. Zoonotic SARS-CoV likely evolved to infect humans by a series of transmission events between humans and animals for sale in China. Using synthetic biology, we engineered the spike protein (S) from a civet strain, SZ16, into our epidemic strain infectious clone, creating the chimeric virus icSZ16-S, which was infectious but yielded progeny viruses incapable of propagating in vitro. After introducing a K479N mutation within the S receptor binding domain (RBD) of SZ16, the recombinant virus (icSZ16-S K479N) replicated in Vero cells but was severely debilitated in growth. The in vitro evolution of icSZ16-S K479N on human airway epithelial (HAE) cells produced two viruses (icSZ16-S K479N D8 and D22) with enhanced growth on HAE cells and on delayed brain tumor cells expressing the SARS-CoV receptor, human angiotensin I converting enzyme 2 (hACE2). The icSZ16-S K479N D8 and D22 virus RBDs contained mutations in ACE2 contact residues, Y442F and L472F, that remodeled S interactions with hACE2. Further, these viruses were neutralized by a human monoclonal antibody (MAb), S230.15, but the parent icSZ16-S K479N strain was eight times more resistant than the mutants. These data suggest that the human adaptation of zoonotic SARS-CoV strains may select for some variants that are highly susceptible to select MAbs that bind to RBDs. The epidemic, icSZ16-S K479N, and icSZ16-S K479N D22 viruses replicate similarly in the BALB/c mouse lung, highlighting the potential use of these zoonotic spike SARS-CoVs to assess vaccine or serotherapy efficacy in vivo.
Situational characteristics and factors associated with officer-involved shootings: a systematic review protocol
Creators: name: Simas, Vini
name: Orr, Robin
name: Canetti, Elisa
name: Neumann, Lucy
name: Walker, Joel
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Tactical Research Unit
subject: TRU

description: Systematic review protocol. The objective of this systematic review is to identify and synthesise available literature surrounding situational characteristics of officer-involved shootings.
Elements of a Successful Big Data Hackathon in a Smart City Context
Creators: name: Jetzek, Thorhildur
Publisher: name: Geoforum Perspektiv
Year: 2016

description: A case study of a Smart City initiative that has successfully applied the triple helix model to create an informal collaboration between academia, government and private industry. The study recounts how a group of university students, participating in a big data hackathon, managed to create a smart city solution prototype based on open data in only 48 hours. The solution can make the municipality more cost efficient and improve citizen services, while also contributing to reduced CO2 emissions and thus addressing a difficult societal challenge. A special attention is paid to how the smart city vision based on the triple helix model is used to align interests and enable an informal collaboration between heterogeneous stakeholders, effectively creating a win-win-win situation.
description: Geoforum Perspektiv, Vol 14 No 25 (2015): Smart City and Spatial Data
Relativistic electron vortex beams in a laser field
Creators: name: Bandyopadhyay, Pratul
name: Basu, Banasri
name: Chowdhury, Debashree
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The orbital angular momentum Hall effect and spin Hall effect of electron vortex beams (EVB) have been studied for the EVBs interacting with laser field. In the scenario of paraxial beam, the cumulative effect of the orbit-orbit interaction of EVBs and laser fields drives the orbital Hall effect, which in turn produces a shift of the center of the beam from that of the field-free case towards the polarization axis of photons. Besides, for non-paraxial beams one can also perceive a similar shift of the center of the beam owing to spin Hall effect involving spin-orbit interaction. Our analysis suggests that the shift in the paraxial beams will always be larger than that in non-paraxial beams.
description: 5 pages. arXiv admin note: text overlap with arXiv:1311.7338
Kan busdata beregne trafik? Erfaring fra Aalborg Kommune med busdata
Creators: name: Sørensen, Stine
Publisher: name: Geoforum Perspektiv
Year: 2016

description: Dagligt transporteres tusindvis af passagerer fra busstop til busstop. Både busser og bilers hastighed afhænger af de samme trafikale forhold og ved at kombinere geografisk data, om blandt andet busstoppesteder, og data fra bussernes sensorer, kan man få nogle meget interessante resultater. Bussernes hastighed kan nemlig beregnes ud fra disse oplysninger og benyttes som indikator for den generelle hastighed i trafikken. Derudover kan der let kobles mere data på, som gør beregningerne endnu mere nøjagtige. Dette er bare ét eksempel på, hvordan kommunale data kan bruges til at gøre vores byer smartere og mere intelligente. Vi har så meget data i de danske kommuner, og vi har endnu ikke set det fulde potentiale heraf.
description: Geoforum Perspektiv, Vol 14 No 25 (2015): Smart City and Spatial Data
Pathways of Cross-Species Transmission of Synthetically Reconstructed Zoonotic Severe Acute Respiratory Syndrome Coronavirus
Creators: name: Baric, Ralph
name: Donaldson, Eric
name: Sheahan, Timothy
name: Rockx, Barry
name: Corti, Davide
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Zoonotic severe acute respiratory syndrome coronavirus (SARS-CoV) likely evolved to infect humans by a series of transmission events between humans and animals in markets in China. Virus sequence data suggest that the palm civet served as an amplification host in which civet and human interaction fostered the evolution of the epidemic SARS Urbani strain. The prototypic civet strain of SARS-CoV, SZ16, was isolated from a palm civet but has not been successfully cultured in vitro. To propagate a chimeric recombinant SARS-CoV bearing an SZ16 spike (S) glycoprotein (icSZ16-S), we constructed cell lines expressing the civet ortholog (DBT-cACE2) of the SARS-CoV receptor (hACE2). Zoonotic SARS-CoV was completely dependent on ACE2 for entry. Urbani grew with similar kinetics in both the DBT-cACE2 and the DBT-hACE2 cells, while icSZ16-S only grew in DBT-cACE2 cells. The SZ16-S mutant viruses adapted to human airway epithelial cells and displayed enhanced affinity for hACE2 but exhibited severe growth defects in the DBT-cACE2 cells, suggesting that the evolutionary pathway that promoted efficient hACE2 interactions simultaneously abolished efficient cACE2 interactions. Structural modeling predicted two distinct biochemical interaction networks by which zoonotic receptor binding domain architecture can productively engage hACE2, but only the Urbani mutational repertoire promoted efficient usage of both hACE2 and cACE2 binding interfaces. Since dual species tropism was preserved in Urbani, it is likely that the virus evolved a high affinity for cACE2/hACE2 receptors through adaptation via repeated passages between human and civet hosts. Furthermore, zoonotic SARS-CoV was variably neutralized by antibodies that were effective against the epidemic strain, highlighting their utility for evaluating passive immunization efficacy.
Materials containing single-, Di-, Tri-, and multi-metal atoms bonded to C, N, S, P, B, and O species as advanced catalysts for energy, sensor, and biomedical applications
Creators: name: Tiwari, Jitendra
N.
name: Kumar, Krishan
name: Safarkhani, Moein
name: Umer, Muhammad
name: Vilian, A. T. Ezhil
name: Beloqui, Ana
name: Bhaskaran, Gokul
name: Huh, Yun Suk
name: Han, Young-Kyu
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Modifying the coordination or local environments of single-, di-, tri-, and multi-metal atom (SMA/DMA/TMA/MMA)-based materials is one of the best strategies for increasing the catalytic activities, selectivity, and long-term durability of these materials. Advanced sheet materials supported by metal atom-based materials have become a critical topic in the fields of renewable energy conversion systems, storage devices, sensors, and biomedicine owing to the maximum atom utilization efficiency, precisely located metal centers, specific electron configurations, unique reactivity, and precise chemical tunability. Several sheet materials offer excellent support for metal atom-based materials and are attractive for applications in energy, sensors, and medical research, such as in oxygen reduction, oxygen production, hydrogen generation, fuel production, selective chemical detection, and enzymatic reactions. The strong metal–metal and metal–carbon with metal–heteroatom (i.e., N, S, P, B, and O) bonds stabilize and optimize the electronic structures of the metal atoms due to strong interfacial interactions, yielding excellent catalytic activities. These materials provide excellent models for understanding the fundamental problems with multistep chemical reactions. This review summarizes the substrate structure-activity relationship of metal atom-based materials with different active sites based on experimental and theoretical data. Additionally, the new synthesis procedures, physicochemical characterizations, and energy and biomedical applications are discussed. Finally, the remaining challenges in developing efficient SMA/DMA/TMA/MMA-based materials are presented.
Fork of Specificity of a patients’ responses during CBT as a predictor of treatment efficacy
Creators: name: Hitchcock, Caitlin
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences

description: Cognitive behavioural therapy (CBT) is a recommended psychological treatment for common mental health problems including depression and anxiety disorders. CBT involves the use of cognitive (eg. cognitive reappraisal and evidence gathering tasks) and behavioural (eg. planning and executing behavioural experiments) techniques to challenge maladaptive thoughts and beliefs which cause distress and functional impairment in patients’ lives. When working with these belief challenging techniques, individuals are required to provide specific, concrete detail from their past. For example, when completing evidence gathering tasks to challenge a negative belief (e.g., ‘Nobody cares about me’), individuals are required to provide specific pieces of information which either support (e.g., when I went to Jane’s party, she didn’t talk to me) or contradict that belief (e.g., I had a good conversation with Jane the day after the party). Treatment manuals that guide clinicians to deliver CBT (e.g., Beck’s seminal Cognitive Therapy and the emotional disorders; Beck, 1976) emphasise the importance of encouraging the patient to be concrete and specific in the information they provide. However, there is no empirical evidence to suggest that higher specificity in a patient’s responses during CBT will aid treatment efficacy. Approximately 40% of individuals treated with CBT will not experience adequate improvement, emphasising the need to identify patient-level factors which may enhance or impede treatment efficacy (Cuijpers et al., 2014). In this study, we aim to advance the field by exploring whether the specificity of patient responses to therapist’s questions during CBT predicts treatment efficacy. Machine learning techniques will be used to assess the specificity of patients’ responses during sessions of internet-enabled CBT, delivered as part of routine NHS practice.
A Validated Nonlinear Kelvin-Helmholtz Benchmark for Numerical Hydrodynamics
Creators: name: Lecoanet, Daniel
name: McCourt, Michael
name: Quataert, Eliot
name: Burns, Keaton J.
name: Vasil, Geoffrey M.
name: Oishi, Jeffrey S.
name: Brown, Benjamin P.
name: Stone, James M.
name: O'Leary, Ryan M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The nonlinear evolution of the Kelvin-Helmholtz instability is a popular test for code verification. To date, most Kelvin-Helmholtz problems discussed in the literature are ill-posed: they do not converge to any single solution with increasing resolution. This precludes comparisons among different codes and severely limits the utility of the Kelvin-Helmholtz instability as a test problem. The lack of a reference solution has led various authors to assert the accuracy of their simulations based on ad-hoc proxies, e.g., the existence of small-scale structures. This paper proposes well-posed Kelvin-Helmholtz problems with smooth initial conditions and explicit diffusion. We show that in many cases numerical errors/noise can seed spurious small-scale structure in Kelvin-Helmholtz problems. We demonstrate convergence to a reference solution using both Athena, a Godunov code, and Dedalus, a pseudo-spectral code. Problems with constant initial density throughout the domain are relatively straightforward for both codes. However, problems with an initial density jump (which are the norm in astrophysical systems) exhibit rich behavior and are more computationally challenging. In the latter case, Athena simulations are prone to an instability of the inner rolled-up vortex; this instability is seeded by grid-scale errors introduced by the algorithm, and disappears as resolution increases. Both Athena and Dedalus exhibit late-time chaos. Inviscid simulations are riddled with extremely vigorous secondary instabilities which induce more mixing than simulations with explicit diffusion. Our results highlight the importance of running well-posed test problems with demonstrated convergence to a reference solution. To facilitate future comparisons, we include the resolved, converged solutions to the Kelvin-Helmholtz problems in this paper in machine-readable form.
description: Reference solution snapshots can be found at https://doi.org/10.5281/zenodo.5803759
Persistent Replication of Severe Acute Respiratory Syndrome Coronavirus in Human Tubular Kidney Cells Selects for Adaptive Mutations in the Membrane Protein
Creators: name: Baric, Ralph
name: Clementi, Massimo
name: Ferioli, Elena
name: Poli, Guido
name: Sims, Amy
name: Ghezzi, Silvia
name: Sampaolo, Michela
name: Canducci, Filippo
name: Vincenzi, Elisa
name: Conaldi, Pier Giulio
name: Pacciarini, Filippo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Severe acute respiratory syndrome (SARS) is a systemic disease characterized by both lung pathology and widespread extrapulmonary virus dissemination causing multiple organ injuries. In this regard, renal dysfunction is an ominous sign in patients with SARS. Indeed, clusters of SARS coronavirus (SARS-CoV) particles have been detected in the cytoplasm of renal tubular epithelial cells in postmortem studies, explaining the presence of infectious virus in the urine of SARS patients. In order to investigate the potential SARS-CoV kidney tropism, we have evaluated the susceptibility of human renal cells of tubular and glomerular origin to in vitro SARS-CoV infection. Immortalized cultures of differentiated proximal tubular epithelial cells (PTEC), glomerular mesangial cells (MC), and glomerular epithelial cells (podocytes) were found to express the SARS-CoV receptor angiotensin-converting enzyme 2 on their surface. Productive infection, however, occurred only in PTEC but not in glomerular cells. A transient infection with poor virus production was observed in MC, whereas podocytes were not permissive to SARS-CoV infection. In contrast to the cytopathic infection of the Vero E6 cell line, SARS-CoV did not cause overt cytopathic effects in PTEC or MC. Of interest, PTEC, but not MC, maintained stable levels of SARS-CoV production in serial subcultures, suggesting a persistent state of infection. In this regard, a SARS-CoV variant with increased replication capacity in PTEC was selected after four serial subculture passages. This SARS-CoV variant acquired a single nonconservative amino acid change from glutamic acid (E) to alanine (A) at position 11 in the viral membrane (M) protein. The E11A point mutation was sufficient for enhanced SARS-CoV replication and persistence in PTEC when introduced in a SARS-CoV recombinant infectious clone. These findings indicate that human PTEC may represent a site of SARS-CoV productive and persistent replication favoring the emergence of viral variants with increased replication capacity, at least in these kidney cells.
Biopsychosocial factors associated with sport-related injuries in adolescents who play team sports: a scoping review protocol
Creators: name: Sainsbury, David
name: Netto, Kevin
name: Downs, Jennepher
name: McKenna, Leanda
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Adolescent Sports Injury

description: Biopsychosocial factors associated with sport-related injuries in adolescents who play team sports: a scoping review protocol.
Sensitivity Gains by Mismatched Probabilistic Shaping for Optical Communication Systems
Creators: name: Fehenberger, Tobias
name: Lavery, Domaniç
name: Maher, Robert
name: Alvarado, Alex
name: Bayvel, Polina
name: Hanik, Norbert
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Probabilistic shaping of quadrature amplitude modulation (QAM) is used to enhance the sensitivity of an optical communication system. Sensitivity gains of 0.43 dB and 0.8 dB are demonstrated in back-to-back experiments by shaping of 16QAM and 64QAM, respectively. Further, numerical simulations are used to prove the robustness of probabilistic shaping to a mismatch between the constellation used and the signal-to-noise ratio (SNR) of the channel. It is found that, accepting a 0.1 dB SNR penalty, only four shaping distributions are required to support these gains for 64QAM.
description: Title and introduction were updated and the discussion of Section IV-B was extended. Additionally, some minor modifications were made to the manuscript
USO DA TELEREABILITAÇÃO PELA FISIOTERAPIA NO TRATAMENTO DE IDOSOS: SCOPING REVIEW
Creators: name: de Santana Silva, João
name: Gabriel, Clécio
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: Questão de pesquisa: Qual o contexto da inserção da telereabilitação pela fisioterapia no tratamento de idosos? Objetivo do estudo: Identificar e mapear as características da telereabilitação no tratamento fisioterapêutico para idosos. Estratégia de busca •P (população): idosos submetidos ao tratamento fisioterapêutico; •C (conceito): telereabilitação; •C (contexto): o uso da telereabilitação no tratamento fisioterapêutico para idosos; Bases de dados para busca: U.S. National Library of Medicine (PubMed), Web of Science, Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Scopus e Scielo. Critérios de inclusão: o uso da telereabilitação pelo profissional fisioterapeuta, intervenção realizada a distância e idade média da amostra igual ou maior que 60 anos. Critérios de exclusão: artigos duplicados entre as bases, tratamento em não idosos, protocolos publicados sem resultados e desfechos, intervenção realizada presencialmente, revisão sistemática ou integrativa. Roteiro de realização da pesquisa •1º passo: Pesquisa limitada nos bancos de dados, a fim de analisar palavras contidas nos títulos, nos resumos e nos termos índices para descrever os artigos; •2º passo: Escolha das palavras-chave; •3º passo: Leitura dos títulos e resumos, de acordo com os critérios de elegibilidade; •4º passo: Leitura do texto completo, com o intuito de mapear as variáveis estabelecidas (título, autores, ano de publicação, objetivo do estudo, intervenção realizada, dispositivo utilizado, caracterização da amostra através da idade, sexo e condição de saúde, e, por fim, os desfechos apresentados); •5º passo: Tabulação e análise dos dados.
Perspektiver og udfordringer ved at etablere SMART CITY og SMART COMMUNITY-løsninger
Creators: name: Møller, Thomas
name: Dyreborg, Sine
Publisher: name: Geoforum Perspektiv
Year: 2016

description: SMART CITY-initiativer eller SMART COMMUNITY (herefter: SMART CITY) er nogle af de termer, der anvendes til at beskrive en trend i de store internationale bysamfund såsom Rio, London, Barcelona, München, Tokyo og København. Trenden går ud på at gøre bysamfundene mere ”intelligente” ved at opsamle, analysere og anvende information om fra byrummene. Et af fundamenterne i SMART CITY er digitalisering. Danmark har igennem mange år haft en førende position inden for digitalisering, og de første SMART CITY-initiativer ved at blive realiseret. Vejdirektoratet har sammen med Devoteam siden 2014 arbejdet for at etablere en SMART CITY-trafikløsning med realtidsdata fra billister. Denne artikels ambition er at dele vores erfaringer fra projektet med andre, der står – eller kommer til at stå - med de samme udfordringer.
description: Geoforum Perspektiv, Vol 14 No 25 (2015): Smart City and Spatial Data
Search for single top-quark production via flavour changing neutral currents at 8 TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for single top-quark production via flavour-changing neutral current processes from gluon plus up- or charm-quark initial states in proton-proton collisions at the LHC is presented. Data collected with the ATLAS detector in 2012 at a centre-of-mass energy of 8 TeV and corresponding to an integrated luminosity of 20.3 fb$^{-1}$ are used. Candidate events for a top quark decaying into a lepton, a neutrino and a jet are selected and classified into signal- and background-like candidates using a neural network. No signal is observed and an upper limit on the production cross-section multiplied by the $t \rightarrow \ellνb$ branching fraction is set. The observed 95% CL limit is $σ_{qg \rightarrow t} \times \mathcal{B}(t \rightarrow Wb) \times \mathcal{B}(W \rightarrow \ell ν) < 3.4$ pb and the expected 95% CL limit is $σ_{qg \rightarrow t} \times \mathcal{B}(t \rightarrow Wb) \times \mathcal{B}(W \rightarrow \ell ν) < 2.9$ pb. The observed limit can be interpreted as upper limits on the coupling constants of the flavour-changing neutral current interactions divided by the scale of new physics $κ_{ugt}/Λ< 10 \times 10^{-3}$ TeV$^{-1}$ and $κ_{cgt}/Λ< 23 \times 10^{-3}$ TeV$^{-1}$ and on the branching fractions $\mathcal{B}(t \rightarrow ug) < 1.2 \times 10^{-4}$ and $\mathcal{B}(t \rightarrow cg) < 6.4 \times 10^{-4}$.
description: 29 pages plus the Autors list and cover page (45 pages in total), 10 figures, 3 tables, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/TOPQ-2014-13/, This version includes modifications described in the erratum that can be found at https://doi.org/10.1140/epjc/s10052-021-09929-5
People’s perspective of living with complex wounds – a scoping study protocol
Creators: name: Pađen, Ljubiša
name: Griffiths, Jane
name: Cullum, Nicky
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Nursing
subject: FOS: Health sciences
subject: CHRONIC WOUNDS
subject: COMPLEX WOUNDS
subject: LIVING WITH WOUNDS
subject: PATIENT EXPERIENCE
subject: PATIENT PERSPECTIVE
subject: WOUNDS

description: This is the protocol for a scoping study of people's perspective of living with complex wounds. It explicitly describes the methodology for this scoping review.
Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge
Creators: name: Donaldson, Eric
name: Rockx, Barry
name: Stadler, Konrad
name: Sheahan, Timothy
name: Corti, Davide
name: Baric, Ralph
name: Lanzavecchia, Antonio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002, and detailed phylogenetic and epidemiological analyses have suggested that it originated from animals. The spike (S) glycoprotein has been identified as a major component of protective immunity, and 23 different amino acid changes were noted during the expanding epidemic. Using a panel of SARS-CoV recombinants bearing the S glycoproteins from isolates representing the zoonotic and human early, middle, and late phases of the epidemic, we identified 23 monoclonal antibodies (MAbs) with neutralizing activity against one or multiple SARS-CoV spike variants and determined the presence of at least six distinct neutralizing profiles in the SARS-CoV S glycoprotein. Four of these MAbs showed cross-neutralizing activity against all human and zoonotic S variants in vitro, and at least three of these were mapped in distinct epitopes using escape mutants, structure analyses, and competition assays. These three MAbs (S109.8, S227.14, and S230.15) were tested for use in passive vaccination studies using lethal SARS-CoV challenge models for young and senescent mice with four different homologous and heterologous SARS-CoV S variants. Both S227.14 and S230.15 completely protected young and old mice from weight loss and virus replication in the lungs for all viruses tested, while S109.8 completely protected mice from weight loss and clinical signs in the presence of viral titers. We conclude that a single human MAb can confer broad protection against lethal challenge with multiple zoonotic and human SARS-CoV isolates, and we identify a robust cocktail formulation that targets distinct epitopes and minimizes the likely generation of escape mutants.
Analysis of four syringe dispensing machine point-of-access data 2017–2020 in Melbourne, Australia: machine utilisation and client demographics
Creators: name: Kerr, P
name: Cossar, RD
name: Livingston, Michael
name: Jacka, D
name: Dietze, Paul
name: O’Keefe, D
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Background: Australian needle and syringe distribution occurs via a mix of modalities, including syringe dispensing machines (SDMs). SDMs are electronic vending machines providing (often) 24-h access to needles/syringes and may attract greater numbers of people who are younger, female, and/or have limited connection to health care services compared to individuals accessing fixed-site needle and syringe programs (NSPs). However, validating the demographic characteristics of SDM clients has proven difficult in previous research. Methods: In this paper, we analyse SDM order and client demographic data from four SDMs located in South-East Melbourne, Australia, and compare this against the managing fixed-site NSP between May 2017 and December 2020. SDM data were collected via a novel 0–9 numeric keypad input tool. Via the tool, SDM clients were requested to input their categorised age, gender and postcode. Given the novelty of the tool, we evaluate the feasibility of the data collection method. We analysed data according to: (1) total SDM orders made, (2) estimated ‘unique SDM presentations’ and (3) describing the demographics of unique SDM clients. Importantly, we noted substantial invalid demographic data, and consequently, severely restricted data for analysis. Results: There were 180,989 SDM orders made across the four SDMs to an estimated 90,488 unique SDM presentations. There was little variation in unique presentations across days of the week, but 69% occurred out of NSP operating hours. Across the study period, the SDMs distributed 66% of the number of syringes distributed by the fixed-site NSP. Due to invalid demographic data, our restriction method provided only 10,914 (6% of all data) unique presentations for analysis. There were some demographic differences between SDM and NSP client, but these should be treated with caution. Conclusions: The data collection tool provides a novel means of comparing SDM and fixed-site presentations, demonstrating the substantial expansion of service via the SDMs. However, the validity of the demographic data was highly questionable and requires significant data coding, meaning it is not feasible for community NSPs. While we recommend the inclusion of automatically collected SDM order data, the use of a 0–9 numeric keypad to collect demographic data—while an innovation—requires alteration to support NSP data.
1-s2.0-S0828282X22009072-main.pdf
Creators: name: Patt, Eli
name: Singhania, Asmita
name: Roberts, Amy E.
name: U. Morton, Sarah
Publisher: name: Health Research Alliance
Year: 2023
Subjects: Cardiology (incl. cardiovascular diseases)

description: Congenital heart disease (CHD) is the most common birth anomaly, affecting almost 1% of infants. Neurodevelopmental delay is the most common extracardiac feature in people with CHD. Many factors may contribute to neurodevelopmental risk, including genetic factors, CHD physiology, and the prenatal/postnatal environment. Damaging vari- ants are most highly enriched among individuals with extracardiac anomalies or neurodevelopmental delay in addition to CHD, indicating that genetic factors have an impact beyond cardiac tissues in people with CHD. Potential sources of genetic risk include large deletions or duplications that affect multiple genes, such as 22q11 deletion syn- drome, single genes that alter both heart and brain development, such as CHD7, and common variants that affect neurodevelopmental resiliency, such as APOE. Increased use of genome-sequencing tech- nologies in studies of neurodevelopmental outcomes in people with CHD will improve our ability to detect relevant genes and variants. Ultimately, such knowledge can lead to improved and more timely intervention of learning support for affected children.
Well-Being and Ill-Being Trajectories of Parents Living with Children and People Living with a Romantic Partner
Creators: name: Sisson, Natalie
name: Willroth, Emily
name: Le, Bonnie
name: Ford, Brett
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Health Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: coronavirus
subject: COVID
subject: parenting
subject: romantic relationships

description: This registration includes a pre-registration for a project regarding well- and ill-being trajectories of parents living with children and people living with a romantic partner throughout the COVID-19 coronavirus pandemic.
Open Data DK skaber vækst og transparens
Creators: name: Mathiassen, Anna Katrine
name: Lindstrøm, Michelle Bach
Publisher: name: Geoforum Perspektiv
Year: 2016

description: Vores digitale verden består af nuller og et-taller og i takt med den øgede digitalisering, bliver mængden af data større og større. Derfor er et af de nyeste buzzwords Open Data, som åbner for et helt nyt forretningsområde, hvor kernen er tilgængelig data. Men hvad er Open Data, hvad kan det bruges til og af hvem? Det offentlige har enorme mængde data, og det kan være en god ide at dele dem. I juni 2015 blev Open Data DK lanceret. Det har til formål at sætte Open Data på den nationale dagsorden, understøtte datadreven vækst og fremme transparensen i det danske samfund.
description: Geoforum Perspektiv, Vol 14 No 25 (2015): Smart City and Spatial Data
Working Memory and Conflict Adaptation II
Creators: name: Freitas, Antonio
Publisher: name: Open Science Framework
Year: 2022

description: This is an exact replication of "Working Memory and Conflict Adaptation"; the only difference is that we plan to run this study with 100 participants (whereas we planned to run the previous study with 75 participants). The reason for this replication is that our earlier study yielded support for our pre-registered hypothesis for analyses of response time but not for analyses of accuracy (where the critical three-way interaction had a p value between .05 and .10.
"Es gibt keinen Grund, das bewährte System über Bord zu werfen"
Creators: name: Ruh, Ulrich
name: Robbers, Gerhard
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 45 Nr. 11 (1991): Herder Korrespondenz, Band 45, Heft 11
Rigid orbits and sheets in reductive Lie algebras over fields of prime characteristic
Creators: name: Premet, Alexander
name: Stewart, David I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 17B45

description: Let $G$ be a simple simply-connected algebraic group over an algebraically closed field $k$ of characteristic $p>0$ with $\mathfrak{g}={\rm Lie}(G)$. We discuss various properties of nilpotent orbits in $\mathfrak{g}$, which have previously only been considered over $\mathbb{C}$. Using a combination of theoretical and computational methods, we extend to positive characteristic various calculations of de Graaf with nilpotent orbits in exceptional Lie algebras. In particular, we classify those orbits which are reachable, those which satisfy a certain related condition due to Panyushev, and determine the codimension in the centraliser $\mathfrak{g}_e$ of its the derived subalgebra $[\mathfrak{g}_e,\mathfrak{g}_e]$. Some of these calculations are used to show that the list of rigid nilpotent orbits in $\mathfrak{g}$, the classification of sheets of $\mathfrak{g}$ and the distribution of the nilpotent orbits amongst them are independent of good characteristic, remaining the same as in the characteristic zero case. We also give a comprehensive account of the theory of sheets in reductive Lie algebras over algebraically closed fields of good characteristic.
description: revised version, many typos corrected, 25 pages
A Comprehensive Survey of Potential Game Approaches to Wireless Networks
Creators: name: Yamamoto, Koji
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Potential games form a class of non-cooperative games where unilateral improvement dynamics are guaranteed to converge in many practical cases. The potential game approach has been applied to a wide range of wireless network problems, particularly to a variety of channel assignment problems. In this paper, the properties of potential games are introduced, and games in wireless networks that have been proven to be potential games are comprehensively discussed.
description: 44 pages, 6 figures, to appear in IEICE Transactions on Communications, vol. E98-B, no. 9, Sept. 2015
Smart Cities – 50 mia. ”ting” på internettet – og det skal styres!
Creators: name: Olsen, Jes Bruun
Publisher: name: Geoforum Perspektiv
Year: 2016

description: Smart Cities er det nye sorte i større byer, og er sat på dagsordenen i et stort antal kommuner på tværs af Danmark. Visionerne og målene er mange og projekterne er mangfoldige. Som med alle andre hypede tiltag fører det en masse ny teknologi med sig, nye platforme, nye gadgets, dingenoter, sensorer, nye applikationer og et nærmest uendeligt behov for kapacitet. Vi skubber data generering og dataopsamlingen ud i omgivelserne og i det yderste af vores organisation. Men er vi klar til at håndtere denne udvikling i de eksisterende organisationer med de nuværende roller.
description: Geoforum Perspektiv, Vol 14 No 25 (2015): Smart City and Spatial Data
Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63
Creators: name: Burkett, Susan
name: Pickles, Raymond J.
name: Yount, Boyd
name: Baric, Ralph S.
name: Donaldson, Eric F.
name: Sims, Amy C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Historically, coronaviruses were predominantly associated with mild upper respiratory disease in humans. More recently, three novel coronaviruses associated with severe human respiratory disease were found, including (i) the severe acute respiratory syndrome coronavirus, associated with a significant atypical pneumonia and 10% mortality; (ii) HKU-1, associated with chronic pulmonary disease; and (iii) NL63, associated with both upper and lower respiratory tract disease in children and adults worldwide. These discoveries establish coronaviruses as important human pathogens and underscore the need for continued research toward the development of platforms that will enable genetic manipulation of the viral genome, allowing for rapid and rational development and testing of candidate vaccines, vaccine vectors, and therapeutics. In this report, we describe a reverse genetics system for NL63, whereby five contiguous cDNAs that span the entire genome were used to generate a full-length cDNA. Recombinant NL63 viruses which contained the expected marker mutations replicated as efficiently as the wild-type NL63 virus. In addition, we engineered the heterologous green fluorescent protein gene in place of open reading frame 3 (ORF3) of the NL63 clone, simultaneously creating a unique marker for NL63 infection and demonstrating that the ORF3 protein product is nonessential for the replication of NL63 in cell culture. The availability of the NL63 and NL63gfp clones and recombinant viruses provides powerful tools that will help advance our understanding of this important human pathogen.
Self-Triggering? An Exploration of Individuals who Seek Reminders of Trauma
Creators: name: Bellet, Benjamin
name: Jones, Payton
name: McNally, Richard
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Clinical Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Trauma survivors who self-trigger, or seek reminders of their traumatic events, have been noted in the clinical literature but have not yet been the subject of systematic empirical inquiry. This paper presents the results of two exploratory studies of self-triggering. In Study 1 (N = 545), we estimate the behavior’s clinical relevance among trauma survivors. In Study 2 (N = 360), we examine descriptive characteristics of self-triggering, as well as potential motivations for the behavior. We found that self-triggering is uniquely associated with more severe PTSD symptoms. Self-triggering takes place via a wide variety of methods, and can become compulsive for many individuals. Reasons endorsed for self-triggering comprised several broad motives, but the desire to make meaning of one’s trauma was most predictive of self-triggering frequency. Limitations, clinical implications, and directions for further research are discussed.
The Vampire and the FOOL
Creators: name: Kotelnikov, Evgenii
name: Kovács, Laura
name: Reger, Giles
name: Voronkov, Andrei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: D.2.4; F.3.1; F.4.1; I.2.3; I.2.5

description: This paper presents new features recently implemented in the theorem prover Vampire, namely support for first-order logic with a first class boolean sort (FOOL) and polymorphic arrays. In addition to having a first class boolean sort, FOOL also contains if-then-else and let-in expressions. We argue that presented extensions facilitate reasoning-based program analysis, both by increasing the expressivity of first-order reasoners and by gains in efficiency.
Gode data er fundamentet for Smart Cities
Creators: name: Steffensen, Bente
name: Jensen, Louise Albæk
name: Colding, Tina Svan
name: Lunding, Lasse Borum
Publisher: name: Geoforum Perspektiv
Year: 2016

description: Grunddataprogrammet er sat i verden for at løfte kvaliteten af offentlige data og sikre en lettilgængelig og stabil datadistribution. Det kommer private virksomheder, den offentlige sektor og borgerne til gavn i mange sammenhænge. Et eksempel på dette er Smart Cities, hvor data og teknologi kombineret med borgerinddragelse danner grundlag for intelligent byudvikling.
description: Geoforum Perspektiv, Vol 14 No 25 (2015): Smart City and Spatial Data
Assessment of Service Quality and Customer Satisfaction: A case study of Ethiopian Air Lines
Creators: name: Gashaw Girma Kassahun
Publisher: name: Zenodo
Year: 2011

description: Today competition is not only rife, but growing more intense constantly. However, companies need to start paying keen attention to their competitors, they must understand their customers. Airlines are suffering from each competition. They have to believe customers as core concept of their business; customer satisfaction is what guarantees the future of air lines and it is achievable by taking up their services and passengers’ needs. In other words, service quality is typically defined in terms of consumer satisfaction. The purpose of this study is to measure the service quality and its subsequent effect on customer satisfaction at Ethiopian airlines using a model that describes various dimensions of service quality. To this purpose the researcher has studied the service quality of the air line using SERVQUAL model. Convenience sampling technique was used in the study to take a sample from the infinite population. A total sample of 150 respondents who have made a flight with Ethiopian airlines were taken as a respondent. A questionnaire was designed based on the model in order to examine all the five factors of service quality in the model for air line industry. It is inclusively concluded that passengers of EAL are not satisfied with the perceived services of three dimensions of the model and it warns the air line to focus on passengers expectations. Tangibles, assurance, responsiveness, reliability and empathy are five features of the model and in tangibles and reliability the passengers are satisfied, but in the remaining three passengers feel dissatisfied. Managers should train employees, improve visually attractive facilities and coordinate all people, departments and organizations involved with the services. Finally, managers at EAL should measure passengers’ satisfaction and service quality seasonally to keep the services corresponded with customers’ opinions.
Phantom Space-times in Fake Supergravity
Creators: name: Taam, Maryam Bu
name: Sabra, Wafic A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss phantom metrics admitting Killing spinors in fake N=2, D=4 supergravity coupled to vector multiplets. The Abelian U(1) gauge fields in the fake theory have kinetic terms with the wrong sign. We solve the Killing spinor equations for the standard and fake theories in a unified fashion by introducing a parameter which distinguishes between the two theories. The solutions found are fully determined in terms of algebraic conditions, the so-called stabilisation equations, in which the symplectic sections are related to a set of functions. These functions are harmonic in the case of the standard supergravity theory and satisfy the wave-equation in flat (2+1)-space-time in the fake theory. Explicit examples are given for the minimal models with quadratic prepotentials.
description: 11 pages
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
Creators: name: Becker, Michelle M
name: Johnston, Robert E.
name: Denison, Mark R.
name: Sims, Amy C.
name: Sheahan, Timothy
name: Corti, Davide
name: Rockx, Barry
name: Graham, Rachel L.
name: Pickles, Raymond J.
name: Donaldson, Eric F.
name: Baric, Ralph S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonotic organisms in culture, and isolating full-length genomes for cloning and genetic studies. The ability to design and recover pathogens reconstituted from synthesized cDNAs has the potential to overcome these obstacles by allowing studies of replication and pathogenesis without identification of reservoir species or cultivation of primary isolates. Here, we report the design, synthesis, and recovery of the largest synthetic replicating life form, a 29.7-kb bat severe acute respiratory syndrome (SARS)-like coronavirus (Bat-SCoV), a likely progenitor to the SARS-CoV epidemic. To test a possible route of emergence from the noncultivable Bat-SCoV to human SARS-CoV, we designed a consensus Bat-SCoV genome and replaced the Bat-SCoV Spike receptor-binding domain (RBD) with the SARS-CoV RBD (Bat-SRBD). Bat-SRBD was infectious in cell culture and in mice and was efficiently neutralized by antibodies specific for both bat and human CoV Spike proteins. Rational design, synthesis, and recovery of hypothetical recombinant viruses can be used to investigate mechanisms of transspecies movement of zoonoses and has great potential to aid in rapid public health responses to known or predicted emerging microbial threats.
Non-linear violent disc instability with high Toomre's Q in high-redshift clumpy disc galaxies
Creators: name: Inoue, Shigeki
name: Dekel, Avishai
name: Mandelker, Nir
name: Ceverino, Daniel
name: Bournaud, Frederic
name: Primack, Joel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We utilize zoom-in cosmological simulations to study the nature of violent disc instability (VDI) in clumpy galaxies at high redshift, $z=1$--$5$. Our simulated galaxies are not in the ideal state assumed in Toomre instability, of linear fluctuations in an isolated, uniform, rotating disk. There, instability is characterised by a $Q$ parameter below unity, and lower when the disk is thick. Instead, the high-redshift discs are highly perturbed. Over long periods they consist of non-linear perturbations, compact massive clumps and extended structures, with new clumps forming in inter-clump regions. This is while the galaxy is subject to frequent external perturbances. We compute the local, two-component $Q$ parameter for gas and stars, smoothed on a $\sim1~{\rm kpc}$ scale to capture clumps of $10^{8-9}~{\rm M}_\odot$. The $Q<1$ regions are confined to collapsed clumps due to the high surface density there, while the inter-clump regions show $Q$ significantly higher than unity. Tracing the clumps back to their relatively smooth Lagrangian patches, we find that $Q$ prior to clump formation typically ranges from unity to a few. This is unlike the expectations from standard Toomre instability. We discuss possible mechanisms for high-$Q$ clump formation, e.g. rapid turbulence decay leading to small clumps that grow by mergers, non-axisymmetric instability, or clump formation induced by non-linear perturbations in the disk. Alternatively, the high-$Q$ non-linear VDI may be stimulated by the external perturbations such as mergers and counter-rotating streams. The high $Q$ may represent excessive compressive modes of turbulence, possibly induced by tidal interactions.
description: Accepted for publication in MNRAS. 20 pages, 21 figures