cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanochemical synthesis: route to novel rock-salt-structured high-entropy oxides and oxyfluorides
Creators: name: Lin, Ling
name: Wang, Kai
name: Azmi, Raheleh
name: Wang, Junbo
name: Sarkar, Abhishek
name: Botros, Miriam
name: Najib, Saleem
name: Cui, Yanyan
name: Stenzel, David
name: Anitha Sukkurji, Parvathy
name: Wang, Qingsong
name: Hahn, Horst
name: Schweidler, Simon
name: Breitung, Ben
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Materials Science, general
subject: Characterization and Evaluation of Materials
subject: Polymer Sciences
subject: Solid Mechanics
subject: Crystallography and Scattering Methods
subject: Classical Mechanics
subject: DDC 540 / Chemistry & allied sciences

description: Abstract A facile mechanochemical reaction at ambient temperature was successfully applied to synthesize novel single-phase rock-salt-structured high-entropy oxides, containing five, six and seven metal elements in equiatomic amounts. This synthesis approach overcomes the limitations of the commonly known synthesis procedures, which would result in multiple-phase compounds. Redox-sensitive elements, such as Fe2+ and Mn2+, can now be considered. The corresponding single-phase Li-containing high-entropy oxyfluorides were obtained by introducing LiF into the lattice using the same strategy. All materials show single-phase rock-salt structures with lattice parameters depending on the incorporated ion sizes. Solid solution states result in high configurational entropies, and all elements appear homogenously distributed over the whole cationic and anionic sublattice. The straightforward synthesis technique, combined with utilized simple binary oxide precursors, paves the way for a multitude of novel high-entropy oxide and oxyfluoride compounds. The compounds were studied by means of X-ray diffraction, transmission electron microscopy, energy-dispersive X-ray spectroscopy and Mössbauer spectroscopy.
DeepSeg: deep neural network framework for automatic brain tumor segmentation using magnetic resonance FLAIR images
Creators: name: Zeineldin, Ramy A.
name: Karar, Mohamed E.
name: Coburger, Jan
name: Wirtz, Christian R.
name: Burgert, Oliver
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Brain tumor
subject: Computer-aided diagnosis
subject: Convolutional neural networks
subject: Deep learning
subject: DDC 620 / Engineering & allied operations

description: Abstract Purpose Gliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fluid-attenuated inversion recovery (FLAIR) MRI modality can provide the physician with information about tumor infiltration. Therefore, this paper proposes a new generic deep learning architecture, namely DeepSeg, for fully automated detection and segmentation of the brain lesion using FLAIR MRI data. Methods The developed DeepSeg is a modular decoupling framework. It consists of two connected core parts based on an encoding and decoding relationship. The encoder part is a convolutional neural network (CNN) responsible for spatial information extraction. The resulting semantic map is inserted into the decoder part to get the full-resolution probability map. Based on modified U-Net architecture, different CNN models such as residual neural network (ResNet), dense convolutional network (DenseNet), and NASNet have been utilized in this study. Results The proposed deep learning architectures have been successfully tested and evaluated on-line based on MRI datasets of brain tumor segmentation (BraTS 2019) challenge, including s336 cases as training data and 125 cases for validation data. The dice and Hausdorff distance scores of obtained segmentation results are about 0.81 to 0.84 and 9.8 to 19.7 correspondingly. Conclusion This study showed successful feasibility and comparative performance of applying different deep learning models in a new DeepSeg framework for automated brain tumor segmentation in FLAIR MR images. The proposed DeepSeg is open source and freely available at https://github.com/razeineldin/DeepSeg/.
Practice patterns in Fournier's Gangrene in Europe and implications for a prospective registry study
Creators: name: Schneidewind, Laila
name: Kiss, Bernhard
name: Stangl, Fabian P.
name: Tandogdu, Zafer
name: Wagenlehner, Florian
name: Johansen, Truls E. Bjerklund
name: Köves, Béla
name: Medina-Polo, Jose
name: Tapia, Ana Maria
name: Kranz, Jennifer
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Fournier’s gangrene (FG) is a life-threatening, necrotizing infection. Due to the rareness of the disease, it is challenging to plan robust prospective studies. This study aims to describe current practice patterns of FG in Europe and identify implications for planning a prospective FG registry. Methods: Online non-validated 17-items survey among urologists treating FG in in European hospitals. Questionnaires were analyzed with LimeSurvey (LimeSurvey GmbH Hamburg, Germany). Results: 229 responses from ten different European countries were submitted, and 117 (51.1%) urologists completed the questionnaire. The departments treat a mean of 4.2 (SD 3.11) patients per year. The urology department mostly takes the lead in treating FG patients (n = 113; 96.6%). The practice in FG is very heterogenic and mostly case-based all over Europe, e.g., vacuum-assisted wound closure (VAC) is mostly used (n = 50; 42.7%) as adjunct wound. The biggest challenges in FG are the short time to diagnosis and treatment, standardization and establishment of guidelines, and disease awareness. Additionally, participants stated that an international registry is an outstanding initiative, and predictive models are needed. Conclusions: There is no standard of care in the diagnosis, treatment, and long-term care of FG all over Europe. Further research could be conducted with a prospective registry.
Effector XopQ-induced stromule formation in Nicotiana benthamiana depends on ETI signaling components ADR1 and NRG1
Creators: name: Prautsch, Jennifer
name: Erickson, Jessica
name: Özyürek, Sedef
name: Gormanns, Rahel
name: Franke, Lars
name: Lu, Yang
name: Marx, Jolina
name: Niemeyer, Frederik
name: Parker, Jane E
name: Stuttmann, Johannes
name: Schattat, Martin Hartmut
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 580

description: In Nicotiana benthamiana, the expression of the Xanthomonas effector XANTHOMONAS OUTER PROTEIN Q (XopQ) triggers RECOGNITION OF XOPQ1 (ROQ1)-dependent effector-triggered immunity (ETI) responses accompanied by the accumulation of plastids around the nucleus and the formation of stromules. Both plastid clustering and stromules were proposed to contribute to ETI-related hypersensitive cell death and thereby to plant immunity. Whether these reactions are directly connected to ETI signaling events has not been tested. Here, we utilized transient expression experiments to determine whether XopQ-triggered plastid reactions are a result of XopQ perception by the immune receptor ROQ1 or a consequence of XopQ virulence activity. We found that N. benthamiana mutants lacking ROQ1, ENHANCED DISEASE SUSCEPTIBILITY 1, or the helper NUCLEOTIDE-BINDING LEUCINE-RICH REPEAT IMMUNE RECEPTORS (NLRs) N-REQUIRED GENE 1 (NRG1) and ACTIVATED DISEASE RESISTANCE GENE 1 (ADR1), fail to elicit XopQ-dependent host cell death and stromule formation. Mutants lacking only NRG1 lost XopQ-dependent cell death but retained some stromule induction that was abolished in the nrg1_adr1 double mutant. This analysis aligns XopQ-triggered stromules with the ETI signaling cascade but not to host programmed cell death. Furthermore, data reveal that XopQ-triggered plastid clustering is not strictly linked to stromule formation during ETI. Our data suggest that stromule formation, in contrast to chloroplast perinuclear dynamics, is an integral part of the N. benthamiana ETI response and that both NRG1 and ADR1 hNLRs play a role in this ETI response.
Economic burden of secondary hyperparathyroidism in Germany : a matched comparison
Creators: name: Reichel, Helmut
name: Seibert, Eric
name: Tillmann, Frank-Peter
name: Barck, Isabella
name: Grava, Astride
name: Schneider, Kim Maren
name: Meise, Dominic
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Purpose: Secondary hyperparathyroidism (SHPT) of renal origin is a progressive complication in chronic kidney disease (CKD) and is associated with serious osseous and non-osseous complications, CKD progression, and economic burden for healthcare systems worldwide. We aimed at assessing characteristics, healthcare resource utilization, and costs of incident SHPT patients in CKD stage 3 (CKD3) and 4 (CKD4), using administrative claims data. Methods: German claims data were used to identify CKD3 and CKD4 patients, who were stratified by the occurrence of incident SHPT. Patients with SHPT were matched 1:1 to non-SHPT patients with the same CKD stage using propensity scores. Matched groups were compared during a 2-year follow-up period. Results: Overall, 1156 CKD3 and 517 CKD4 incident SHPT patients and their respective matches were identified. Mean number of all-cause hospitalizations were significantly higher among SHPT patients (2.7 vs. 2.0 in CKD3, 2.8 vs. 1.5 in CKD4) during follow-up. Similarly, the mean number of outpatient encounters was significantly higher among the SHPT cohorts (95.0 vs. 64.3 in CKD3, 101.4 vs. 49.8 in CKD4). SHPT patients progressed to CKD5 more often (6.1% vs. 1.2% from CKD3, 26.7% vs. 2.9% from CKD4, both P < 0.01) resulting in a higher proportion of dialysis (6.1% vs. 1.3% in CKD3, 22.1% vs. 3.7% in CKD4, both P < 0.01). Consequently, average all-cause healthcare costs significantly increased per patient (€19,477 vs. €15,115 in CKD3, €25,921 vs. €12,265 in CKD4). Conclusions: Patients with CKD3&4 and incident SHPT of renal origin presented with significantly higher healthcare resource utilization and costs, as well as increased disease progression compared to non-SHPT patients.
Additional file 1 of Effect of Microsporidia MB infection on the development and fitness of Anopheles arabiensis under different diet regimes
Creators: name: Boanyah, Godfred Yaw
name: Koekemoer, Lizette L.
name: Herren, Jeremy K.
name: Bukhari, Tullu
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 1.Experimental design to determine the effect of different larval diet regimes on Microsporidia MB prevalence and intensity and influence on Microsporidia MB on >An. arabiensis development fitness.
Fear of falling from the perspective of affected persons : a systematic review and qualitative meta-summary using Sandelowski and Barroso's method
Creators: name: Baltes-Schmitt, Marion
name: Herber, Oliver Rudolf
name: Meyer, Gabriele
name: Stephan, Astrid
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Fear of falling (FoF) affects a large number of older people, whether they have a history of falls or not. This has an impact on their lives. FoF is a potentially modifiable factor, which has been identified as one of the most important threats to older people's autonomy. Objectives: To gain a comprehensive understanding of the phenomenon, we con- ducted a systematic review and meta-summary. The available evidence from qualita- tive research exploring how people experience FoF and how FoF affects daily living was aggregated. Methods: We followed the approach by Sandelowski and Barroso (2007) as a method to aggregate knowledge based on an exhaustive literature search. We searched the databases CINAHL, MEDLINE, PsycINFO and SSCI systematically for relevant articles as well as grey literature until September 2020. Out of the included studies, findings were extracted, edited, grouped and abstracted into meta-findings. Finally, the mani- fest frequency effect size of each abstracted meta-finding was calculated. Results: Out of 2978 identified studies, 15 met our inclusion criteria, which were pub- lished between 1993 and 2017 and included a total of 276 participants. We extracted 578 findings, and the abstraction process resulted in 183 meta-findings. We identi- fied three main topics: ‘Triggers and reasons for FoF identified by affected people’, ‘Consequences attributed to FoF’ and ‘Strategies to manage FoF in daily life’. Conclusion: Our findings demonstrate that FoF has a far-reaching impact on the lives of those affected. With the aggregation of the existing qualitative data with the appli- cation of the frequency effect size, we were able to identify three areas of particular importance to those affected: (1) controlling the risk, (2) creating a safe environment and (3) staying independent. Implications for practice these three areas of particular importance to those affected should be taken into account when revisiting or creating new interventions to prevent or reduce FoF.
Wildfire: Assessing and Quantifying Risk Exposure and Mitigation Across Western Utilities
Creators: name: Macomber, Eric
name: Wara, Michael
name: Mastrandrea, Michael
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: Stanford Woods Institute for the Environment
CEPP
Wildfire

description: Wildfire risk is a serious and growing concern for electric utilities. For the increasing number of utilities that are currently exposed to wildfire risk or are likely to be exposed to wildfire risk in the near future, creating and implementing a wildfire mitigation plan is a crucial step toward limiting overall risk. The knowledge of utilities and regulators in regions that have already experienced catastrophic wildfires and developed solutions to reduce the potential harms posed by wildfire is a key information source that can assist in this adaptation and improvement process. Many utilities, particularly in the Western United States, have already developed a robust set of actions and practices to mitigate wildfire risk.
Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy
Creators: name: Vaxevanis, Christoforos K.
name: Bauer, Marcus
name: Subbarayan, Karthikeyan
name: Friedrich, Michael
name: Massa, Chiara
name: Biehl, Katharina
name: Al-Ali, Haifa Kathrin
name: Wickenhauser, Claudia
name: Seliger, Barbara
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Myelodysplastic syndromes (MDS) and their progression to secondary acute myeloid leukemia (sAML) are associated with an altered protein expression including extracellular matrix (ECM) components thereby promoting an inflammatory environment. Since the role of the proteoglycan biglycan (BGN) as an inflammatory mediator has not yet been investigated in both diseases and might play a role in disease progression, its expression and/or function was determined in cell lines and bone marrow biopsies (BMBs) of MDS and sAML patients and subpopulations of MDS stem cells by Western blot and immunohistochemistry. The bone marrow (BM) microenvironment was analyzed by multispectral imaging, patients’ survival by Cox regression. ROC curves were assessed for diagnostic value of BGN. All cell lines showed a strong BGN surface expression in contrast to only marginal expression levels in mononuclear cells and CD34+ cells from healthy donors. In the MDS-L cell line, CD34−CD33+ and CD34+CD33+ blast subpopulations exhibited a differential BGN surface detection. Increased BGN mediated inflammasome activity of CD34−CD33+TLR4+ cells was observed, which was inhibited by direct targeting of BGN or NLRP3. BGN was heterogeneously expressed in BMBs of MDS and sAML, but was not detected in control biopsies. BGN expression in BMBs positively correlated with MUM1+ and CD8+, but negatively with CD33+TLR4+ cell infiltration and was accompanied by a decreased progression-free survival of MDS patients. BGN-mediated inflammasome activation appears to be a crucial mechanism in MDS pathogenesis implicating its use as suitable biomarker and potential therapeutic target.
title: Spain’s Hydrogen Ambition: Between reindustrialisation and export-led energy integration with the EU
Creators: name: Escribano, Gonzalo
name: Urbasos, Ignacio
Publisher: name: Research Institute for Sustainability (RIFS)
Year: 2023

description: This paper examines the recent evolution of the domestic and external dimension of hydrogen in Spain. When published in 2020, the Spanish Hydrogen Strategy was focused on the creation of hydrogen clusters that could concentrate production and consumption, attracting economic activity associated with the molecule. For this reason, the external dimension of Spain's hydrogen strategy was relatively modest in its nascent state. The Russian invasion of Ukraine and the EU Commission's call in the REPowerEU to increase the level of ambition for renewable hydrogen has led to a change in Spain's hydrogen policy, reinforcing its external and energy security dimensions and contributing to a more geopolitically resilient Europe. This new approach to hydrogen development creates a complex tension between the promises of industrial development and the potential for integrating Spain in the European energy system.
description: RIFS Discussion Paper
description: International Hydrogen Policy
Fibroblast activation protein overexpression in gastrointestinal tumors : protocol for a systematic review and meta-analysis
Creators: name: Sunami, Yoshiaki
name: Ronellenfitsch, Ulrich
name: Kleeff, Jörg H.
name: Gomes Dos Santos Ferreira Rebelo, Artur Luis
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: A hallmark of gastrointestinal cancer, especially pancreatic cancer, is the dense stromal tumor microenvironment in which cancer-associated fibroblasts (CAFs) represent the major stromal cell type. Preclinical studies have demonstrated that depletion of fibroblast activation protein (FAP)–positive CAFs results in increased survival. Objective: We present the protocol for a systematic review and meta-analysis that aim to assess the currently available evidence on the effect of FAP expression on survival and clinical characteristics in gastrointestinal cancers. Methods: The literature search and data analysis will be conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement. The databases PubMed/MEDLINE, Web of Science Core Collection, Cochrane Library, and ClinicalTrials.gov will be searched via their respective online search engines. A meta-analysis comparing patients with and without FAP overexpression with the following outcomes will be performed: postoperative survival (overall and median survival; 1-, 2-, 3-, and 5-year survival rates), histological differentiation (grading), local tumor invasion, lymph node metastases, and distant metastases. Odds ratios will be calculated for binary data, and weighted mean differences and relative SD differences will be determined for continuous data. The 95% CI, heterogeneity measures, and statistical significance will be reported for each outcome. The chi-square and Kruskal-Wallis tests will be used to evaluate statistical significance. A P value of <.05 will be considered statistically significant. Results: Database searches will commence in April 2023. The meta-analysis will be completed by December 2023. Conclusions: In recent years, several publications on FAP overexpression in gastrointestinal tumors have been published. The only published meta-analysis on this topic dates to 2015. It included 15 studies on various solid tumors and only 8 studies focusing exclusively on gastrointestinal tumors. The expected results of the present analysis will provide new evidence on the prognostic value of FAP in gastrointestinal tumors and thereby support health care professionals and patients in their decision-making.
title: Framework Development
Creators: name: St. John, Kristen
Publisher: name: JMU Scholarly Commons
Year: 2018
Subjects: subject: Earth sciences--Study and teaching

description: Building on a prior reports, surveys, and workshops, this NSF-funded GER Framework project engaged ~200 geoscience educators and researchers through a sequenced series of virtual and face-to-face events to share ideas, gain feedback, and create and revise priority research questions, or "Grand Challenges", that span 10 geoscience education research themes. For each theme, several Grand Challenges and recommended strategies have been proposed by the community. This framework development chapter describes the underlying project goal, its objectives, and its vision. It also outlines the processes used to develop the Framework and the intended scope and audience.
description: Citation: St. John, Kristen (2018). "Framework Development". In St. John, K. (Ed.) (2018). Community Framework for Geoscience Education Research. National Association of Geoscience Teachers. Retrieved from
            http://commons.lib.jmu.edu/ger_framework/1.  DOI: 10.5072/ger_framework/1
Rocking motion in solid proteins studied by the 15N proton-decoupled R1ρ relaxometry
Creators: name: Krushelnitsky, Alexey
name: Hempel, Günter
name: Jurack, Hannes
name: Ferreira, Tiago M.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 530

description: Recently it has been revealed that proteins in solid samples undergo slow overall rocking. The parameters of this motion depend on intermolecular interactions. Therefore, the characterization of the rocking motion enables one to investigate protein–protein interactions. NMR R1ρ relaxometry is the most suitable tool to study slow molecular motions. However, the time scale of the rocking motion is on the edge of the dynamics window of the standard R1ρ experiment, precluding the R1ρ data analysis from being precise and reliable. In this work, we apply a modified R1ρ relaxation method to characterize the slow motion in solids with much higher precision and reliability. The modification is the simultaneous use of a strong 1H-CW pulse and a weak/moderate 15N spin-lock pulse. We demonstrate theoretically and experimentally that under this condition, R1ρ decays have a significantly better signal-to-noise ratio and a much shorter “dead time” caused by the initial oscillations compared to the conventional R1ρ experiment. Moreover, the proton-decoupled R1ρ's can be measured at a much smaller difference between the spin-lock and MAS frequencies; thus, much slower molecular motions can be sampled. The proton decoupling during the 15N spin-lock pulse also suppresses the interfering coherent spin–spin relaxation pathway at low spin-lock fields, which overlaps the Bloch–McConnell (chemical exchange) range of R1ρ dispersions. The proton-decoupled and standard R1ρ experiments were used to study the rocking motion of 15N,2H-enriched protein GB1 in two solid forms, microcrystals and lyophilized amorphous powder. The most striking finding is that the correlation function of this motion consists of two components with very different correlation times, 2–20 μs and a few hundred μs. The rocking motion parameters in microcrystals and powder are quite different, revealing the distinct nature of inter-protein interactions in these two samples.
Additional file 1 of Early endovascular intervention for unfavorable remodeling of the thoracic aorta after open surgery for acute DeBakey type I aortic dissection: study protocol for a multicenter, randomized, controlled trial
Creators: name: Liu, Yu
name: Li, Ling
name: Xiao, Zhenghua
name: Peng, Liqing
name: Yang, Peng
name: Lu, Chen
name: Zhang, Yu
name: Wang, Haiyue
name: Hu, Jia
Publisher: name: figshare
Year: 2023
Subjects: Space Science
Medicine
Biotechnology

description: Additional file 1.
File for  Closed-Loop Optimization of Tetris-Inspired Robotic Morphology Evolution
Creators: name: Wang, Yuqian
Publisher: name: Zenodo
Year: 2025
Subjects: Bayesian Optimization
Closed-Loop
Tetris-Inspired
Robotic Morphology

description: This dataset contains experimental results and computational tools for the paper 'Closed-Loop Optimization of Tetris-Inspired Robotic Morphology Evolution'. Includes:

- 280 morphology-speed pairs (Excel)

- Top 10 STL models for 3D printing

- Bayesian optimization codebase
title: Italian Hydrogen Policy: Drivers, Constraints and Recent Developments
Creators: name: Prontera, Andrea
Publisher: name: Research Institute for Sustainability (RIFS)
Year: 2023

description: Italy presents, potentially, some important comparative advantages in the emerging clean hydrogen economy. However, unlike other large EU countries, Italy has not yet issued a comprehensive strategy on hydrogen nor has it developed a coherent hydrogen diplomacy. It was only with the National Recovery and Resilience Plan, launched in the wake of the COVID-19 crisis, that Italy upgraded its measures for promoting green hydrogen and related activities. The main players in the Italian hydrogen landscape are national industrial actors, especially state-owned energy companies. This leading role can be an important asset to overcome the problems related to an industrial system otherwise composed of small and medium companies, which can find it difficult to compete with hydrogen frontrunners. Externally, Italy has supported all the European and multilateral initiatives on hydrogen, although in the EU the country is a policy-taker rather than a policy-shaper. The main focus of the Italian international approach is linked to the hydrogen hub concept, which targets the MENA region and is also supported by its national energy companies. This concept has received a further push after the beginning of the war in Ukraine. However, its practical realization is very problematic because of domestic and external challenges.
description: RIFS Discussion Paper
description: International Hydrogen Policy
Deep Learning Enabled Data-Driven Detection of Wind Turbine Operating Conditions Using Transformer Networks
Creators: name: Sultan, Rubbiya
name: Ahmed, Nourhan
name: Faller, Luca
name: Lichtenstein, Timo
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2024
Subjects: Wind turbines
Early fault detection
Transformers
Deep learning

description: Test data (1min) Test data (10min) Test data (30min) Training data (1min) Training data (10min) Training data (30min) Precision Recall F1 (calibrated) Prevalence
sj-doc-1-lis-10.1177_09610006221111199 – Supplemental material for Librarians self-efficacy in ICT-based library operations and services: A survey of librarians working in libraries of Aligarh Muslim University Library System
Creators: name: Nazim, Mohammad
name: Munshi, Shamim Aktar
name: Ashar, Mohammad
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description: Supplemental material, sj-doc-1-lis-10.1177_09610006221111199 for Librarians self-efficacy in ICT-based library operations and services: A survey of librarians working in libraries of Aligarh Muslim University Library System by Mohammad Nazim, Shamim Aktar Munshi and Mohammad Ashar in Journal of Librarianship and Information Science
Immune checkpoint inhibition and targeted therapy for melanoma : a patient-oriented cross-sectional comparative multicentre study
Creators: name: Thiem, Alexander
name: Mashhadiakbar, Pegah
name: Cussigh, Christiane
name: Hassel, Jessica C.
name: Grimmelmann, Imke
name: Gutzmer, Ralf
name: Schlaak, Max Simon
name: Heppt, Markus V.
name: Dücker, Pia
name: Hüning, Svea
name: Schulmeyer, Lena
name: Schilling, Bastian
name: Haferkamp, Sebastian
name: Ziemer, Mirjana
name: Moritz, Rose K. C.
name: Hagelstein, Victoria
name: Terheyden, Patrick
name: Posch, Christian
name: Gaiser, Maria
name: Kropp, Peter
name: Emmert, Steffen
name: Müller, Britta
name: Tietze, Julia K.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background Choosing the adequate systemic treatment for melanoma is driven by clinical parameters and personal preferences. Objective Evaluation of the impact of disease and treatment on the daily life of patients receiving systemic therapy for melanoma. Methods A German-wide, cross-sectional comparative study was conducted at 13 specialized skin cancer centres from 08/2020 to 03/2021. A questionnaire was distributed to assess patients' perception of disease and symptoms, the impact of their current treatment on quality of life (QOL) and activities, adverse events (AEs), therapeutic visits, as well as believe in and satisfaction with their current systemic melanoma treatment. Patient-reported outcomes (PROs) were rated on a continuous numerical rating scale or selected from a given list. Results Four hundred and fourteen patients with systemic melanoma therapy were included. 359 (87%) received immune checkpoint inhibition (ICI) and 55 (13%) targeted therapy (TT). About 1/3 of patients were adjuvantly treated, the remaining because of unresectable/metastatic melanoma. In subgroup analyses, only in the adjuvant setting, TT patients reported a significant decrease in their treatment associated QOL compared to patients with ICI (p = 0.02). Patients with TT were 1.9 times more likely to report AEs than patients with ICI, a difference being significant just for the adjuvant setting (p = 0.01). ICI treatment intervals differed significantly between adjuvant and unresectable/metastatic setting (p = 0.04), though all patients, regardless of their specific ICI drug, evaluated their treatment frequency as adequate. TT patients with dabrafenib/trametinib (n = 37) or encorafenib/binimetinib (n = 15) did not differ regarding the strain of daily pill intake. Patients older than 63 years rated various PROs better than younger patients. Conclusions Patients evaluated their treatment mainly positively. ICI might be preferred over TT regarding QOL and patient-reported AEs in the adjuvant setting. Older melanoma patients appeared to be less impacted by their disease and more satisfied with their treatment.
Benchmark Biointelligenz
Creators: name: Baumgarten, Yannick
name: Full, Johannes
name: Gaißler, Andrea
name: Hohmann, Silja
name: Kiemel, Steffen
name: Mais, Franziska
name: Miehe, Robert
name: Rentschler, Michael
name: Schutzbach, Maximilian
name: Silber, Nadine
name: Stöber, Lea
name: Casini, Isabella
name: Föller, Stefanie
name: Maiser, Eric
name: Küster, Anna
name: Wagner, Nathalie
Publisher: name: Fraunhofer-Gesellschaft
Year: 2024
Subjects: Biointelligenz
Wertschöpfung
Benchmark

description: Zum Titelbild: Das Titelbild zeigt eine abstrakte Darstellung von Nervenzellen, auch als Neuronen bekannt, die auf sechseckigen Elektroden wachsen. Mittels elektrochemischer Signale werden Reize weitergeleitet, sodass die Neuronen sowohl untereinander als auch mit den Elektroden "kommunizieren". Diese Abbildung symbolisiert die Schnittstelle zwischen biologischen Prozessen und einem informationstechnischem System.
A second life for used batteries from electric vehicles
Creators: name: Spancken, Dominik
name: Stelter, Eva-Maria
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2024
Subjects: Sustainability
battery
recycling
e-mobilbity

description: Sustainable development-A second life for used batteries from electric vehicles E-Mobility in Germany Around 1.4 million purely battery electric vehicles are registered 2024 in Germany [1]. This corresponds to an installed battery capacity of around 50 GWh [2]. The growth rates for e-mobility are in the mid double-digit percentage range. The advantages of battery electric vehicles are that they are locally emission-free and climate-neutral when powered by electricity generated from renewable sources. There are currently still several financial incentives for users of battery electric vehicles, such as free charging with self-generated solar power, exemption from vehicle tax, GHG quota trading and lower operating costs due to significantly longer maintenance intervals compared to vehicles with combustion engines.
sj-docx-1-ebi-10.1177_02780771231165834 - Supplemental material for Guatemalan Maya Q’eqchi’ Seasonal Calendar: Methods to Monitor Climate Change Locally
Creators: name: Thiel, Amanda M.
name: Medinaceli, Armando
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Anthropology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-ebi-10.1177_02780771231165834 for Guatemalan Maya Q’eqchi’ Seasonal Calendar: Methods to Monitor Climate Change Locally by Amanda M. Thiel and Armando Medinaceli in Journal of Ethnobiology
Additional file 8 of Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining
Creators: name: Abu-Bakar, A’edah
name: Ismail, Maihani
name: Zulkifli, M. Zaqrul Ieman
name: Zaini, Nur Aini Sofiyya
name: Shukor, Nur Izzah Abd
name: Harun, Sarahani
name: Inayat-Hussain, Salmaan Hussain
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Supplementary Material 8
Caregiverspro-Mmd Project: Social Media Plan
Creators: name: Tetard, F.
name: Bofarull, Rafael De
name: Lara, E.
name: Zafeiridi, P.
name: Daskalakis, D.
name: Barrué, C.
name: Cortés, U.
name: Cesaroni, F.
Publisher: name: Zenodo
Year: 2016

description: This document consists a deliverable of CAREGIVERSPRO-MMD project and outlines the social media plan for the pilot's sites of the project.
Hermann-Josef Venetz (Hrsg.) / Herbert Vorgrimler (Hrsg.), Das Lehramt der Kirche und der Schrei der Armen
Creators: name: Sievernich, Michael
Publisher: name: Theologie und Philosophie
Year: 1970

description: Theologie und Philosophie, Bd. 61 Nr. 4 (1986): Theologie und Philosophie, Band 61, Heft 4
Efficiency Of An Adjoint Industrial Cfd Code
Creators: name: Dastouri, Z.,
name: Lotz, J.,
name: Naumann, U.,
Publisher: name: Zenodo
Year: 2015
Subjects: optimization
Computational Fluid Dynamics (CFD)
adjoint-based
discrete adjoint code
Navier-Stokes
Automatic Differentiation (AD)
industrial test case

description: Sensitivity analysis with the aim of design optimization is a growing area of interest in Computational Fluid Dynamics (CFD) simulations. However, one of the major challenges is to deal with a large number of design variables for largescale industrial applications. One of the effective solution approaches is to compute adjoint-based sensitivities in the differentiated CFD code. In this paper, we develop a discrete adjoint code for an unstructured pressure-based steady NavierStokes solver using Algorithmic Differentiation (AD) by operator overloading (OO) tool. To reduce the huge memory requirement of the adjoint code we apply effective techniques by implementation of checkpointing schemes and by symbolic differentiation of the iterative linear solver. We combine the flexibility of an operator overloading tool with the efficiency of an adjoint code generated by source transformation through coupling these approaches. Moreover, we improve the performance of the adjoint computation by exploiting the mathematical aspects of the involved fixed-point iteration through reverse accumulation. We compare the effectiveness of these methods in terms of reduction of the numerical cost and accuracy of the sensitivities for the optimization of a vehicle climate duct industrial test case.
Generalized Geologic Map for Land-Use Planning: Butler County, Kentucky
Creators: name: Beck, E. Glynn
name: Williams, David A.
name: Carey, Daniel I.
Publisher: name: Kentucky Geological Survey, University of Kentucky
Year: 2003

description: Abstract:
This map is not intended to be used for selecting individual sites. Its purpose is to inform land-use planners, government officials, and the public in a general way about geologic bedrock conditions that affect the selection of sites for various purposes. The properties of thick soils may supercede those of the underlying bedrock and should be considered on a site to site basis.
title: The Netherlands as a Future Hydrogen Hub for Northwest Europe: Analysing Domestic Developments and International Engagement
Creators: name: Stam, Roelof
name: van der Linde, Coby
name: Stapersma, Pier
Publisher: name: Research Institute for Sustainability (RIFS)
Year: 2023

description: The Dutch government believes hydrogen will play an important role in decarbonizing the energy system. Industry, NGOs and the government work together in the Netherlands to setup low-carbon hydrogen supply chains. The Netherlands is in a good position to make a significant contribution to Europe's low-carbon hydrogen market, thanks to its current role as a European energy hub, large chemical industry, geographic location at the North Sea, offshore wind potential and existing gas and oil infrastructure. The Dutch national hydrogen strategy predominantly focuses on hydrogen produced via electrolysis from renewable electricity. However, there is also room for hydrogen produced from natural gas or waste gases with CCS, given that this effectively contributes to the development of the broader Dutch hydrogen system, without hampering the growth of hydrogen produced via electrolysis from renewable electricity. In the initial market phase, the Dutch government will prioritize hydrogen supply for the hard-to-abate sectors such as heavy industry and heavy-duty transportation. In later market phases more sectors could be using hydrogen as an energy carrier. The Dutch government has chosen for a combination of obligations and a variety of subsidies schemes, to increase investment security and scale up the low-carbon hydrogen market by 2030. Internationally the Netherlands aims to position itself as the low-carbon hydrogen hub of Northwest Europe, connecting international exporters and Dutch domestic production at the North Sea with industrial demand centres in Northwest Europe. Acknowledging the scale of the task at hand, the Dutch government is open for partnerships along the whole value chain to work towards an international low-carbon hydrogen market.
description: RIFS Discussion Paper
description: International Hydrogen Policy
Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors
Creators: name: Nassar, Husam
name: Sippl, Wolfgang
name: Dahab, Rana Abu
name: Taha, Mutasem
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 615

description: GSK3β is a serine/threonine kinase that has been suggested as a putative drug target for several diseases. Recent studies have reported the beneficial effects of cephalosporin antibiotics in cancer and Alzheimer's disease, implying potential inhibition of GSK3β. To investigate this mechanism, four cephalosporins, namely, cefixime, ceftriaxone, cephalexin and cefadroxil were docked into the GSK3β binding pocket. The third-generation cephalosporins, cefixime and ceftriaxone, exhibited the best docking scores due to the exclusive hydrogen bonding between their aminothiazole group and hinge residues of GSK3β. The stability of top-ranked poses and the possibility of covalent bond formation between the carbonyl carbon of the β-lactam ring and the nucleophilic thiol of Cys-199 were evaluated by molecular dynamics simulations and covalent docking. Finally, the in vitro inhibitory activities of the four cephalosporins were measured against GSK3β with and without preincubation. In agreement with the results of molecular docking, cefixime and ceftriaxone exhibited the best inhibitory activities with IC50 values of 2.55 μM and 7.35 μM, respectively. After 60 minutes preincubation with GSK3β, the IC50 values decreased to 0.55 μM for cefixime and 0.78 μM for ceftriaxone, supporting a covalent bond formation as suggested by molecular dynamics simulations and covalent docking. In conclusion, the third-generation cephalosporins are reported herein as GSK3β covalent inhibitors, offering insight into the mechanism behind their benefits in cancer and Alzheimer's disease.
Predictors and consequences of moral distress in home-care nursing : a cross-sectional survey
Creators: name: Petersen, Julia
name: Melzer, Marlen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Nurses frequently face situations in their daily practice that are ethically difficult to handle and can lead to moral distress. Objective:This study aimed to explore the phenomenon of moral distress and describe its work-related predictors and individual consequences for home-care nurses in Germany. Research design: A cross-sectional design was employed. The moral distress scale and the COPSOQ III-questionnaire were used within the framework of an online survey conducted among home-care nurses in Germany. Frequency analyses, multiple linear and logistic regressions, and Rasch analyses were performed. Participants and research context: The invitation to participate was sent to every German home-care service (n = 16,608). Ethical considerations: The study was approved by the Data Protection Office and Ethics Committee of the German Federal Institute for Occupational Safety and Health. Results: A total of 976 home-care nurses participated in this study. Job characteristics, such as high emotional demands, frequent work-life-conflicts, low influence at work, and low social support, were associated with higher disturbance caused by moral distress in home-care nurses. Organizational characteristics of home-care services, such as time margin with patients, predicted moral distress. High disturbance levels due to moral distress predicted higher burnout, worse state of health, and the intention to leave the job and the profession, but did not predict sickness absence. Conclusions:To prevent home-care nurses from experiencing severe consequences of moral distress, adequate interventions should be developed. Home-care services ought to consider family friendly shifts, provide social support, such as opportunities for exchange within the team, and facilitate coping with emotional demands. Sufficient time for patient care must be scheduled and short-term takeover of unknown tours should be prevented. There is a need to develop and evaluate additional interventions aimed at reducing moral distress, specifically in the home-care nursing sector.
Additional file 1 of Vaping habits and respiratory symptoms using a smartphone app platform
Creators: name: Lee, Mi-Sun S.
name: Eum, Ki-Do
name: Allen, Joseph G.
name: Onnela, Jukka-Pekka
name: Christiani, David C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
sj-docx-1-him-10.1177_18333583231197756 – Supplemental material for A documentary analysis of Victorian Government health information assets’ websites to identify availability of documentation for data sharing and reuse in Australia
Creators: name: Riley, Merilyn F.
name: Robinson, Kerin
name: Kilkenny, Monique F
name: Leggat, Sandy G.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Health and Community Services
Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-him-10.1177_18333583231197756 for A documentary analysis of Victorian Government health information assets’ websites to identify availability of documentation for data sharing and reuse in Australia by Merilyn F. Riley, Kerin Robinson, Monique F Kilkenny and Sandy G. Leggat in Health Information Management Journal
European consensus for the diagnosis of MCI and mild dementia : preparatory phase
Creators: name: Festari, Cristina
name: Massa, Federico
name: Ramusino, Matteo Cotta
name: Gandolfo, Federica
name: Nicolosi, Valentina
name: Orini, Stefania
name: Aarsland, Dag
name: Frölich, Lutz
name: Otto, Markus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Abstract: Introduction Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI-mild dementia), and detailed pre-assessment screening (clinical-neuropsychological evaluations, brain imaging, and blood tests). Discussion The Delphi consensus on these assumptions set the stage for the development of the first pan-European workflow for biomarkers? use in the etiological diagnosis of middle-old age neurocognitive disorders at MCI-mild dementia stages. Highlights Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe. A consensus of experts will define a workflow for the rational use of biomarkers. The diagnostic workflow will be patient-centered and based on clinical presentation. The workflow will be updated as new evidence accrues.
Additional file 2 of Effect of Microsporidia MB infection on the development and fitness of Anopheles arabiensis under different diet regimes
Creators: name: Boanyah, Godfred Yaw
name: Koekemoer, Lizette L.
name: Herren, Jeremy K.
name: Bukhari, Tullu
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 2. Main nutritional components of the diets.
sj-docx-1-whe-10.1177_17455057231199038 – Supplemental material for Insights into women’s experiences of giving birth during the coronavirus disease-19 pandemic in Jordan, a cross-sectional survey
Creators: name: Muhaidat, Nadia
name: AlQuabeh, Batool
name: AbdulGhani, Waed
Publisher: name: SAGE Journals
Year: 2023
Subjects: Obstetrics and Gynaecology

description: Supplemental material, sj-docx-1-whe-10.1177_17455057231199038 for Insights into women’s experiences of giving birth during the coronavirus disease-19 pandemic in Jordan, a cross-sectional survey by Nadia Muhaidat, Batool AlQuabeh and Waed AbdulGhani in Women’s Health
Additional file 3 of Temporal transcriptomic profiling elucidates sorghum defense mechanisms against sugarcane aphids
Creators: name: Puri, Heena
name: Grover, Sajjan
name: Pingault, Lise
name: Sattler, Scott E.
name: Louis, Joe
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 3: Supplemental Figure 1. Volcano plots based on the RNA-seq data for each comparison. Red indicates a significant differential expression (adjusted P-value<0.05 and |log2(FC)| >=1). Supplemental Figure 2. Gene ontology (GO) treemap of overrepresented GO terms in module 19 made by REVIGO program for A) Biological functions and B) Molecular functions. Supplemental Figure 3. Gene enrichment analysis of differentially expressed genes (DEGs) in module M4. Supplemental Figure 4. Gene enrichment analysis of differentially expressed genes (DEGs) in module M19.