cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In silico structural elucidation of Nipah virus L protein and targeting RNA-dependent RNA polymerase domain by nucleoside analogs
Creators: name: Abduljalil, Jameel M.
name: Elfiky, Abdo A.
name: Sayed, El-Sayed T. A.
name: AlKhazindar, Maha M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The large (L) protein of Mononegavirales is a multi-domain protein that performs transcription and genome replication. One of the important domains in L is the RNA-dependent RNA polymerase (RdRp), a promising target for antiviral drugs. In this work, we employed rigorous computational comparative modeling to predict the structure of L protein of Nipah virus (NiV). The RdRp domain was targeted by a panel of nucleotide analogs, previously reported to inhibit different viral RNA polymerases, using molecular docking. Best binder compounds were subjected to molecular dynamics simulation to validate their binding. Molecular mechanics/generalized-born surface area (MM/GBSA) calculations estimated the binding free energy. The predicted model of NiV L has an excellent quality as judged by physics- and knowledge-based validation tests. Galidesivir, AT-9010 and Norov-29 scored the top nucleotide analogs to bind to the RdRp. Their binding free energies obtained by MM/GBSA (−31.01 ± 3.9 to −38.37 ± 4.8 kcal/mol) ranked Norov-29 as the best potential inhibitor. Purine nucleotide analogs are expected to harbor the scaffold for an effective drug against NiV. Finally, this study is expected to provide a start point for medicinal chemistry and drug discovery campaigns toward identification of effective chemotherapeutic agent(s) against NiV. Communicated by Ramaswamy H. Sarma
Structural and thermostability insights into cellobiohydrolase of a thermophilic mould Myceliophthora thermophila: in-silico studies
Creators: name: Dadwal, Anica
name: Singh, Vishal
name: Sharma, Shilpa
name: Sahoo, Amaresh Kumar
name: Satyanarayana, Tulasi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Cellobiohydrolase (CBH) is one of the cellulases with a wide range of industrial applications; it plays a pivotal role in cellulose hydrolysis and thus in biofuel production. The structural and thermostability analysis of a CBHII of the thermophilic mold Myceliophthora thermophila (MtCel6A) had been carried out using various in-silico approaches. The validation of 3 D model by the Ramachandran plot indicated 88.5% amino acid residues in the favoured regions. Docking analysis suggested MtCel6A to display a high affinity towards cellotetraose as compared to other substrates. The enzyme exhibited a high tolerance to the end product, cellobiose. The thermostability evaluation by molecular dynamic simulations and principal component analysis confirmed its tolerance to elevated temperatures. The identified thermolabile regions could be targeted for site-directed mutagenesis in order to ameliorate thermostability further. Our experimental data published earlier confirmed the present findings of in-silico studies. The structural and functional characteristics of MtCel6A highlighted its critical features that make it a useful biocatalyst in several industrial processes. Communicated by Ramaswamy H. Sarma
USIA Survey # I93027: Indonesia Radio Managers Study
Creators: name: USIA
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Station's purpose (2); language of station (1); public affairs information (1); news information aired on station (25); news broadcast (3); program via satellite (4); international radio/television (24); radio station job performance (10); characteristics of station (1); amount of international news (4).
ESTIMATION OF PARAMETERS FOR KUMARASWAMY EXPONENTIAL DISTRIBUTION BASED ON PROGRESSIVE TYPE-I INTERVAL CENSORED SAMPLE
Creators: name: Chacko, Manoj
name: Dev, Shilpa S.
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Maximum likelihood estimate
EM algorithm
Bayesian inference
Lindley’s approximation

description: In this paper, we consider the problem of estimation of parameters of the Kumaraswamy exponential distribution using progressive type-I interval censored data. The maximum likelihood estimators (MLEs) of the parameters are obtained. As it is observed that there is no closed-form solutions for the MLEs, we implement the Expectation-Maximization (EM) algorithm for the computation of MLEs. Bayes estimators are also obtained using different loss functions such as the squared error loss function and the LINEX loss function. For the Bayesian estimation, Lindley’s approximation method has been applied. To evaluate the performance of the various estimators developed, we conduct an extensive simulation study. The different estimators and censoring schemes are compared based on average bias and mean squared error. A real data set is also taken into consideration for illustration.
EXPLORING LENGTH BIASED QUASI SUJA DISTRIBUTION: PROPERTIES AND APPLICATIONS
Creators: name: Yerneni, Vidya
name: Aafaq A. Rather
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Length biased quasi suja distribution
Moments
Entropy
Estimation
Simulation

description: This paper introduces a new statistical distribution called length biased quasi suja distribution (LBQS). It explores its properties, including moments, moment generating function(MGF), characteristic function(CF), harmonic mean, reliability, hazard rate and reverse hazard rate. Order statistics of the above distribution is obtained. Furthermore, the paper also examines various entropy which measures the randomness of system, like Renyi entropy and Tsalli’s entropy. It also evaluates Bonferroni and Lorenz curves which are useful in measuring the inequality. It also discusses parameter estimation techniques specifically maximum likelihood estimation and likelihood ratio testing. Moreover, a simulation study has been conducted to demonstrate how well the distribution would perform in real-life situation. The validity of the distribution is also demonstrated with real-world data example of failure data, highlighting its potential for practical applications in data analysis.
Morphological and Behavioral Changes in the Pathogenesis of a Novel Mouse Model of Communicating Hydrocephalus
Creators: name: McCarthy, Ken D.
name: McMullen, Allison B.
name: Baidwan, Gurlal S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Ro1 model of hydrocephalus represents an excellent model for studying the pathogenesis of hydrocephalus due to its complete penetrance and inducibility, enabling the investigation of the earliest cellular and histological changes in hydrocephalus prior to overt pathology. Hematoxylin and eosin staining, immunofluorescence and electron microscopy were used to characterize the histopathological events of hydrocephalus in this model. Additionally, a broad battery of behavioral tests was used to investigate behavioral changes in the Ro1 model of hydrocephalus. The earliest histological changes observed in this model were ventriculomegaly and disorganization of the ependymal lining of the aqueduct of Sylvius, which occurred concomitantly. Ventriculomegaly led to thinning of the ependyma, which was associated with periventricular edema and areas of the ventricular wall void of cilia and microvilli. Ependymal denudation was subsequent to severe ventriculomegaly, suggesting that it is an effect, rather than a cause, of hydrocephalus in the Ro1 model. Additionally, there was no closure of the aqueduct of Sylvius or any blockages within the ventricular system, even with severe ventriculomegaly, suggesting that the Ro1 model represents a model of communicating hydrocephalus. Interestingly, even with severe ventriculomegaly, there were no behavioral changes, suggesting that the brain is able to compensate for the structural changes that occur in the pathogenesis of hydrocephalus if the disorder progresses at a sufficiently slow rate.
Interaction created effective flat bands in conducting polymers
Creators: name: Gulacsi, Zsolt
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: For a general class of conducting polymers with arbitrary large unit cell and different on-site Coulomb repulsion values on different type of sites, I demonstrate in exact terms the emergence possibility of an upper, interaction created "effective" flat band. This last appears as a consequence of a kinetic energy quench accompanied by a strong interaction energy decrease, and leads to a non-saturated ferromagnetic state. This ordered state clearly differs from the known flat-band ferromagnetism. This is because it emerges in a system without bare flat bands, requires inhomogeneous on-site Coulomb repulsions values, and possesses non-zero lower interaction limits at the emergence of the ordered phase.
description: 22 pages, 3 figures
Retailer's Opinions
Creators: name: Istituto Per Le Ricerche Statistiche E L'Analisi Dell'Opinione Pubblica (Gallup) (DOXA)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Popularity of telephone orders; packed goods or goods sold by kilos/litres; popularity of products with a specific brand or trademark; changes in consumption and consumer habits since 1938; buy wholesale or through cooperative organizations; mandatory specialization in retail goods; license system for retailers; worries for your type of retailer; highest income retailers; able to cope with influx of customers; take on more staff members; ability to cut prices; ability to double sales; difference between retail and wholesale prices; profit margin for retailers; reasons for high prices other than taxes; procedural changes to lower prices for retailers and consumers; regular expenses; what attracts a passer-by into the store; what makes occasional buyers local customers; number of employees; social class of customers; when shop was opened.
Four-manifolds, geometries and knots
Creators: name: Hillman, Jonathan
Publisher: name: arXiv
Year: 2002
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57N16, 57M50, 57N13, 57Q45

description: The goal of this book is to characterize algebraically the closed 4-manifolds that fibre nontrivially or admit geometries in the sense of Thurston, or which are obtained by surgery on 2-knots, and to provide a reference for the topology of such manifolds and knots. The first chapter is purely algebraic. The rest of the book may be divided into three parts: general results on homotopy and surgery (Chapters 2-6), geometries and geometric decompositions (Chapters 7-13), and 2-knots (Chapters 14-18). In many cases the Euler characteristic, fundamental group and Stiefel-Whitney classes together form a complete system of invariants for the homotopy type of such manifolds, and the possible values of the invariants can be described explicitly. The strongest results are characterizations of manifolds which fibre homotopically over S^1 or an aspherical surface (up to homotopy equivalence) and infrasolvmanifolds (up to homeomorphism). As a consequence 2-knots whose groups are poly-Z are determined up to Gluck reconstruction and change of orientations by their groups alone. This book arose out of two earlier books "2-Knots and their Groups" and "The Algebraic Characterization of Geometric 4-Manifolds", published by Cambridge University Press for the Australian Mathematical Society and for the London Mathematical Society, respectively. About a quarter of the present text has been taken from these books, and I thank Cambridge University Press for their permission to use this material. The book has been revised in March 2007 and again in November 2022. For details see the end of the preface.
description: This 2022 version replaces the revision published by Geometry & Topology Monographs in March 2007
Omnibus Survey
Creators: name: Istituto Per Le Ricerche Statistiche E L'Analisi Dell'Opinione Pubblica (Gallup) (DOXA)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Car races on the road; buy ice creams; ice cream brands; ice cream for your children; last time you got hacked; decision to have ice cream; advertisement influenced you to make a purchase; book purchases; read a book in last 3-4 months; write to politicians; electoral promises; vote for same Party as you did in 1953 elections for Parliament; non-Communist electors; political party; Prime Minister Signor Scelba; Former Prime Minister Alcide De Gasperi; profession; appliance ownership; size of commune.
Savings and Investment Practices of High Income Families
Creators: name: Istituto Per Le Ricerche Statistiche E L'Analisi Dell'Opinione Pubblica (Gallup) (DOXA)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Savings; family income; types of savings; investments; difference between shares and bonds; safety of investments; shares or bonds lost more value after World War 2 devaluation; stock shares; investments if you could invest between ten and thirty thousands lire a month; stock share installment plans; investment plans; share purchases over next three to four months; insurance on investments; investment trusts; holding companies; yearly budget; profession; appliance ownership, size of commune.
Surface group representations in PU(p,q) and Higgs bundles
Creators: name: Bradlow, Steven B.
name: Garcia-Prada, Oscar
name: Gothen, Peter B.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Algebraic Geometry (math.AG)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 14D20 (Primary) 14H60, 32G13 (Secondary)

description: Using the L^2 norm of the Higgs field as a Morse function, we study the moduli spaces of U(p,q)-Higgs bundles over a Riemann surface. We require that the genus of the surface be at least two, but place no constraints on (p,q). A key step is the identification of the function's local minima as moduli spaces of holomorphic triples. In a companion paper "Moduli spaces of holomorphic triples over compact Riemann surfaces" (math.AG/0211428) we prove that these moduli spaces of triples are non-empty and irreducible. Because of the relation between flat bundles and fundamental group representations, we can interpret our conclusions as results about the number of connected components in the moduli space of semisimple PU(p,q)-representations. The topological invariants of the flat bundles are used to label subspaces. These invariants are bounded by a Milnor-Wood type inequality. For each allowed value of the invariants satisfying a certain coprimality condition, we prove that the corresponding subspace is non-empty and connected. If the coprimality condition does not hold, our results apply to the closure of the moduli space of irreducible representations. This paper, and its companion mentioned above, form a substantially revised version of math.AG/0206012.
description: 44 pages, 2 figures. Minor clarifications and corrections. Final version, to appear in J. Diff. Geom
FUZZY LOGIC RELIABILITY BLOCK DIAGRAM APPROACH FOR PATIENT HEALTH MONITORING USING R PROGRAMMING
Creators: name: Liji Sebastian
name: S., Rita
name: Vennila, J.
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Fuzzy logic
reliability block diagram
health care
efficiency
R programming
membership function

description: In this research, a new approach using fuzzy logic and reliability block diagram (RBD) techniques is used to ensure the reliability of patient health monitoring systems. This technique handles uncertainties in health information, while RBD assesses system reliability by displaying factor relations. The RBD model construct for system components and measure reliability using probabilistic models. Fuzzy logic identifies the effect of uncertainties on overall reliability. Using this approach in a simulated health monitoring scenario, using R, we demonstrate its effectiveness and potential to increase reliable health monitoring for improved patient outcomes and healthcare efficiency. Furthermore, the awareness gained from this study can be directed beyond healthcare such as modern process control and environmental sensing.
General Social Surveys 1977
Creators: name: National Science Foundation (NSF)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: The National Opinion Research Center General Social Surveys contain over 200 questions, many of which have been asked frequently since the first such survey in 1972. These surveys contain a wealth of data concerning attitudes about civil liberties, racial relations, alienation, satisfaction, confidence in institutions, voting behavior, ratings of foreign countries, desired qualities in children, organization membership, important aspects of a job, fear, guns, television watching and radio listening, personal traumas, and various social issues such as the death penalty, abortion, sexual relations, and ERA. Some questions ask respondents to locate themselves on a scale between two positions on an issue. Detailed demographics are included.
Mouse Background Strain Profoundly Influences Paneth Cell Function and Intestinal Microbial Composition
Creators: name: Sartor, R. Balfour
name: Arthur, Janelle C.
name: Kreuk, Lieselotte
name: Jobin, Christian
name: Grossniklaus, Emily
name: Shanahan, Michael T.
name: Henning, Susan J.
name: Gulati, Ajay S.
name: von Furstenberg, Richard J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundIncreasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear. Here, we characterize key differences in Paneth cell function and intestinal microbial composition in two widely utilized, genetically distinct mouse strains (C57BL/6 and 129/SvEv). In doing so, we demonstrate critical influences of host genotype on Paneth cell activity and the enteric microbiota.Methodology and Principal FindingsPaneth cell numbers were determined by flow cytometry. Antimicrobial peptide (AMP) expression was evaluated using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR), acid urea-polyacrylamide gel electrophoresis, and mass spectrometry. Effects of mouse background on microbial composition were assessed by reciprocal colonization of germ-free mice from both background strains, followed by compositional analysis of resultant gut bacterial communities using terminal restriction fragment length polymorphism analysis and 16 S qPCR. Our results revealed that 129/SvEv mice possessed fewer Paneth cells and a divergent AMP profile relative to C57BL/6 counterparts. Novel 129/SvEv á-defensin peptides were identified, including Defa2/18v, Defa11, Defa16, and Defa18. Host genotype profoundly affected the global profile of the intestinal microbiota, while both source and host factors were found to influence specific bacterial groups. Interestingly, ileal α-defensins from 129/SvEv mice displayed attenuated antimicrobial activity against pro-inflammatory E. coli strains, a bacterial species found to be expanded in these animals.Conclusions and SignificanceThis work establishes the important impact of host genotype on Paneth cell function and the composition of the intestinal microbiota. It further identifies specific AMP and microbial alterations in two commonly used inbred mouse strains that have varying susceptibilities to a variety of disorders, ranging from obesity to intestinal inflammation. This will be critical for future studies utilizing these murine backgrounds to study the effects of Paneth cells and the intestinal microbiota on host health and disease.
A Two-Part Mixed-Effects Modeling Framework For Analyzing Whole-Brain Network Data
Creators: name: Simpson, Sean L.
name: Laurienti, Paul J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Applications (stat.AP)
subject: Neurons and Cognition (q-bio.NC)
subject: Quantitative Methods (q-bio.QM)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Whole-brain network analyses remain the vanguard in neuroimaging research, coming to prominence within the last decade. Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system. However, statistical methods for modeling and comparing groups of networks have lagged behind. Fusing multivariate statistical approaches with network science presents the best path to develop these methods. Toward this end, we propose a two-part mixed-effects modeling framework that allows modeling both the probability of a connection (presence/absence of an edge) and the strength of a connection if it exists. Models within this framework enable quantifying the relationship between an outcome (e.g., disease status) and connectivity patterns in the brain while reducing spurious correlations through inclusion of confounding covariates. They also enable prediction about an outcome based on connectivity structure and vice versa, simulating networks to gain a better understanding of normal ranges of topological variability, and thresholding networks leveraging group information. Thus, they provide a comprehensive approach to studying system level brain properties to further our understanding of normal and abnormal brain function.
FUZZY VARIABLE LINEAR PROGRAMMING PROBLEMS USING A FUZZY DUAL SIMPLEX ALGORITHM
Creators: name: Kolli, Srinivasa Rao
name: U.V. Adinarayana Rao
name: Taviti Naidu Gongada
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Linear programming by fuzzy variable quantity
fuzzy numbers
ranking functions
fuzzy simplex and duality algorithms
and trapezoidal fuzzy numbers

description: In modern research, several brilliant minds investigate linear programming problems involving fuzzy variable quantities. Many researchers have turned to linear programming by fuzzy variables to address this problem. Various fuzzy simplex approaches have been developed, using ranking functions to handle fuzzy numbers. Results from this research suggest that linear ranking functions can provide a straightforward interpretation of problems involving linear programming by fuzzy variable quantities. To solve these types of problems, the Fuzzy Dual Simplex Tableau method is often applied, which proves useful for sensitivity analysis when modifications are made to the activity vectors of the fundamental columns. In this study, a numerical case is presented to demonstrate the potential benefits of this approach for future technologies.
Forecasting brain activity based on models of spatiotemporal brain dynamics: A comparison of graph neural network architectures
Creators: name: Wein, Simon
name: Schüller, A.
name: Tomé, A. M.
name: Malloni, W. M.
name: Greenlee, M. W.
name: Lang, E. W.
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Brain connectivity, Graph neural networks, Structure-function relationship, Directed connectivity
subject: 150 Psychologie
subject: 570 Biowissenschaften, Biologie

description: Comprehending the interplay between spatial and temporal characteristics of neural dynamics can contribute to our understanding of information processing in the human brain. Graph neural networks (GNNs) provide a new possibility to interpret graph-structured signals like those observed in complex brain networks. In our study we compare different spatiotemporal GNN architectures and study their ability to model neural activity distributions obtained in functional MRI (fMRI) studies. We evaluate the performance of the GNN models on a variety of scenarios in MRI studies and also compare it to a VAR model, which is currently often used for directed functional connectivity analysis. We show that by learning localized functional interactions on the anatomical substrate, GNN-based approaches are able to robustly scale to large network studies, even when available data are scarce. By including anatomical connectivity as the physical substrate for information propagation, such GNNs also provide a multimodal perspective on directed connectivity analysis, offering a novel possibility to investigate the spatiotemporal dynamics in brain networks.
Survey # 55
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Satisfaction with work (2); workers’ conditions (5); political knowledge (1); Communist manifesto (3); attitudes toward employers and entrepreneurs (4); magazines (5); trade union literature (4); attitudes toward trade unions (6); interest in politics (1); unemployment (2); new labor law (1); cigarette advertising (4); number of acquaintances (1); smoking habits (2); cigarette brands (7); knowledge of notable historical figures (3); family support for SPD (2); attitudes toward SPD (1); price stability (3); margarine brands (3); radio (1); German army (1); German participation in West European defense pact (1); political priorities (1); regional elections (4); voting behavior in last federal election (1); satisfaction with Chancellor Adenauer’s policies (1); expensive cars (1); state intervention in economy (1).
Survey # 56
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Inflation (2); cooking habits (2); attitudes toward education (2); magazines (4); 40-hour work week (3); death penalty (1); astrology (13); satisfaction with Chancellor Adenauer’s policies (1); regional elections (4); economic growth (3); political knowledge (2); resistance to Hitler (2); war crimes (1); economic policy (2); attitudes toward political parties (2); smoking habits (2); cigarette brands (20); fatalism (1); hair product brands (22).
Neisseria gonorrhoeae Suppresses Dendritic Cell-Induced, Antigen-Dependent CD4 T Cell Proliferation
Creators: name: Hobbs, Marcia M.
name: McKinnon, Karen P.
name: Zhu, Weiyan
name: Ventevogel, Melissa S.
name: Duncan, Joseph A.
name: Sempowski, Gregory D.
name: Oldach, Laurel M.
name: Knilans, Kayla J.
name: Anderson, James E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Neisseria gonorrhoeae is the second most common sexually transmitted bacterial pathogen worldwide. Diseases associated with N. gonorrhoeae cause localized inflammation of the urethra and cervix. Despite this inflammatory response, infected individuals do not develop protective adaptive immune responses to N. gonorrhoeae. N. gonorrhoeae is a highly adapted pathogen that has acquired multiple mechanisms to evade its host's immune system, including the ability to manipulate multiple immune signaling pathways. N. gonorrhoeae has previously been shown to engage immunosuppressive signaling pathways in B and T lymphocytes. We have now found that N. gonorrhoeae also suppresses adaptive immune responses through effects on antigen presenting cells. Using primary, murine bone marrow-derived dendritic cells and lymphocytes, we show that N. gonorrhoeae-exposed dendritic cells fail to elicit antigen-induced CD4+ T lymphocyte proliferation. N. gonorrhoeae exposure leads to upregulation of a number of secreted and dendritic cell surface proteins with immunosuppressive properties, particularly Interleukin 10 (IL-10) and Programmed Death Ligand 1 (PD-L1). We also show that N. gonorrhoeae is able to inhibit dendritic cell- induced proliferation of human T-cells and that human dendritic cells upregulate similar immunosuppressive molecules. Our data suggest that, in addition to being able to directly influence host lymphocytes, N. gonorrhoeae also suppresses development of adaptive immune responses through interactions with host antigen presenting cells. These findings suggest that gonococcal factors involved in host immune suppression may be useful targets in developing vaccines that induce protective adaptive immune responses to this pathogen.
STRATEGIES FOR ENHANCING INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) USAGE IN HOME ECONOMICS INSTRUCTIONAL PROCESS IN THE SECONDARY SCHOOLS OF ODIGBO LOCAL GOVERNMENT AREA OF ONDO STATE (Journal of Science, Vocational and Technical Education, JoSVTE, 8(1): 112-28, 2020)
Creators: name: Oluwagbemileke, Feranmi Boluwatife
Publisher: name: figshare
Year: 2023
Subjects: Vocational education and training curriculum and pedagogy
Secondary education
Communication technology and digital media studies

description: This research was carried out to identify the strategies for enhancing Information and Communication Technology (ICT) usage in Home Economics instructional process in the Secondary Schools in Odigbo Local Government Area of Ondo State. Descriptive Survey research design was adopted for the study. Two forms of questionnaires were administered on a total of 200 respondents (8 teachers and 192 students) who were randomly and proportionally sampled for the study. Data collected were analyzed with descriptive statistics (frequency count, percentage and mean) to answer the three research questions, while the postulated hypothesis was subjected to t-test. The findings showed that the use of ICT in teaching-learning process is highly preferred among the Home Economics teachers and secondary school students, though there are militating factors such as lack and poor condition of ICT infrastructures, and electricity interruptions. It was also found out that the mean opinion of the teachers are not significantly different from that of the students on the preference of ICT usage in Home Economics instruction (df=10, t-cal=0.38,t-tab=1.81). It was recommended that enlightenment forums on ICT usage should be organized, and that ICT usage should be made compulsory and properly funded in secondary schools.
Pericytes Regulate Vascular Basement Membrane Remodeling and Govern Neutrophil Extravasation during Inflammation
Creators: name: Wang, Shijun
name: Chen, Zhongming
name: Tzima, Eleni
name: Cao, Canhong
name: Sheibani, Nader
name: Burridge, Keith
name: Bankaitis, Vytas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane. Compared to PMN transendothelial migration, little is known about how PMNs penetrate the latter barriers. Using mouse models and intravital microscopy, we show that migrating PMNs expand and use the low expression regions (LERs) of matrix proteins in the vascular basement membrane (BM) for their transmigration. Importantly, we demonstrate that this remodeling of LERs is accompanied by the opening of gaps between pericytes, a response that depends on PMN engagement with pericytes. Exploring how PMNs modulate pericyte behavior, we discovered that direct PMN-pericyte contacts induce relaxation rather than contraction of pericyte cytoskeletons, an unexpected response that is mediated by inhibition of the RhoA/ROCK signaling pathway in pericytes. Taking our in vitro results back into mouse models, we present evidence that pericyte relaxation contributes to the opening of the gaps between pericytes and to the enlargement of the LERs in the vascular BM, facilitating PMN extravasation. Our study demonstrates that pericytes can regulate PMN extravasation by controlling the size of pericyte gaps and thickness of LERs in venular walls. This raises the possibility that pericytes may be targeted in therapies aimed at regulating inflammation.
Plexin-B2 and Plexin-D1 in Dendritic Cells: Expression and IL-12/IL-23p40 Production
Creators: name: Arthur, Janelle C.
name: Plevy, Scott
name: Steinbach, Erin
name: Ting, Jenny P.-Y.
name: Buntzman, Adam
name: Allen, Irving C.
name: Holl, Eda K.
name: Roney, Kelly E.
name: Frelinger, Jeffrey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell movement and cell-cell interaction during the course of an immune response. In this study, the expression pattern of Plexin-B2 and Plexin-D1 in dendritic cells (DCs), which are central in immune activation, was investigated. Plexin-B2 and Plexin-D1 are reciprocally expressed in myeloid and plasmacytoid DC populations. Plasmacytoid DCs have high Plexin-B2 but low Plexin-D1, while the opposite is true of myeloid DCs. Expression of Plexin-B2 and Plexin-D1 is modulated upon activation of DCs by TLR ligands, TNFα, and anti-CD40, again in a reciprocal fashion. Semaphorin3E, a ligand for Plexin-D1 and Plexin-B2, is expressed by T cells, and interestingly, is dramatically higher on Th2 cells and on DCs. The expression of Plexins and their ligands on DCs and T cells suggest functional relevance. To explore this, we utilized chimeric mice lacking Plxnb2 or Plxnd1. Absence of Plexin-B2 and Plexin-D1 on DCs did not affect the ability of these cells to upregulate costimulatory molecules or the ability of these cells to activate antigen specific T cells. Additionally, Plexin-B2 and Plexin-D1 were dispensable for chemokine-directed in-vitro migration of DCs towards key DC chemokines, CXCL12 and CCL19. However, the absence of either Plexin-B2 or Plexin-D1 on DCs leads to constitutive expression of IL-12/IL-23p40. This is the first report to show an association between Plexin-B2 and Plexin-D1 with the negative regulation of IL-12/IL-23p40 in DCs. This work also shows the presence of Plexin-B2 and Plexin-D1 on mouse DC subpopulations, and indicates that these two proteins play a role in IL-12/IL-23p40 production that is likely to impact the immune response.
IMPROVING THE SPECTRAL EFFICIENCY IN DOWNLINK MULTIPLE USER MULTIPLE INPUT MULTIPLE OUTPUT TRANSMISSION FOR FIFTH GENERATION AND BEYOND WIRELESS COMMUNICATIONS
Creators: name: Abdulmujeeb Akajewole Masud
name: Onyishi, Donatus Uchechukwu
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: ID-MU-MIMO
Interference
MU-MIMO
Resource Utilization
SINR

description: This research presents a solution in Multiple Input Multiple Output (MIMO) wireless systems to meet the growing demand for high data rates in cellular networks. Although MIMO systems offer greater capacity, the higher frequencies used have caused interference problems, especially for mobile User Equipment (UE). This research aims to reduce interference problems in the downlink of Multi-user MIMO (MU-MIMO) systems, with a specific focus on improving Quality of Service (QoS) metrics, such as outage probability and Signal-to-Interference plus Noise Ratio (SINR). Existing solutions to these challenges are complex due to the dynamic nature of the factors involved in modelling real-world scenarios. As such, an Improved Downlink MU-MIMO (ID-MU-MIMO) algorithm is developed as a solution to these problems. The ID-MU-MIMO method employs both single antenna users and multiple transmitter antennas. The performance of the suggested algorithm is compared to the IEEE 802.11ax standard specification and a previous research work for validation and evaluation. Performance measures considered to aid validation included outage probability, spectrum efficiency, and communication connection reliability. On this premise, the outcomes showed that the proposed ID-MU-MIMO scheme outperforms both the IEEE 802.11ax standard and current MD-MU-MIMO systems. In particular, compared to IEEE 802.11ax, the IDMUMIMO technique achieved a 7.71% reduction in interference. When compared to the performance of the random and uniform MD-MU-MIMO algorithms, the proposed ID-MUMIMO scheme showed a reduction in interference in percentages of 8.90% and 2.28%, respectively. The ID-MU-MIMO scheme outpermed the random and uniform MD-MU-MIMO algorithms in terms of Signal-to-Interference Noise Ratio (SINR), outperforming them by 4.27% and 2.75%, respectively, and resource block use, outperforming them by 20.05% and 3.89%, respectively.
Predicting Future Clinical Changes of MCI Patients Using Longitudinal and Multimodal Biomarkers
Creators: name: Zhang, Daoqiang
name: Shen, Dinggang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Accurate prediction of clinical changes of mild cognitive impairment (MCI) patients, including both qualitative change (i.e., conversion to Alzheimer's disease (AD)) and quantitative change (i.e., cognitive scores) at future time points, is important for early diagnosis of AD and for monitoring the disease progression. In this paper, we propose to predict future clinical changes of MCI patients by using both baseline and longitudinal multimodality data. To do this, we first develop a longitudinal feature selection method to jointly select brain regions across multiple time points for each modality. Specifically, for each time point, we train a sparse linear regression model by using the imaging data and the corresponding clinical scores, with an extra ‘group regularization’ to group the weights corresponding to the same brain region across multiple time points together and to allow for selection of brain regions based on the strength of multiple time points jointly. Then, to further reflect the longitudinal changes on the selected brain regions, we extract a set of longitudinal features from the original baseline and longitudinal data. Finally, we combine all features on the selected brain regions, from different modalities, for prediction by using our previously proposed multi-kernel SVM. We validate our method on 88 ADNI MCI subjects, with both MRI and FDG-PET data and the corresponding clinical scores (i.e., MMSE and ADAS-Cog) at 5 different time points. We first predict the clinical scores (MMSE and ADAS-Cog) at 24-month by using the multimodality data at previous time points, and then predict the conversion of MCI to AD by using the multimodality data at time points which are at least 6-month ahead of the conversion. The results on both sets of experiments show that our proposed method can achieve better performance in predicting future clinical changes of MCI patients than the conventional methods.
Survey # 57
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Hopes and fears (1); boredom (1); skills (1); satisfaction with Chancellor Adenauer’s policies (2); liquor brands (7); Saar region (4); reasons for Germany losing WWII (1); expectations if Germany had won WWII (1); attitudes toward political parties (3); taxes (3); smoking habits (5); cigarette brands (11); soup product brands (5); pet ownership (1); books (5); mandatory military service (1); economic policy (2); resistance to Hitler (2); attitudes toward unions (1); razors (3); skin product brands (22); films (1); attitudes toward Jews (2).
O Governo-Movimento
Creators: name: Couto, Cláudio
Publisher: name: Zenodo
Year: 2020
Subjects: Democratic Backsliding
Populism
Authoritarianism
Far Right
Policy Dismantling

description: The article "O Governo-Movimento" discusses how Jair Bolsonaro's government functions more like a movement than a traditional government. The author argues that the main purpose of the movement-government is to incessantly mobilize the masses, while effective public policies are secondary. Irrationality is used to create enemies and strengthen the government's narrative, even if it results in self-destruction and chaos. The movement-government is self-destructive because it produces a great disaster that is partly its objective and partly the consequence of its strategy. Irrationality is the main part of the movement-government's action, and the agreement with the Centrão is merely an instrument to shield this government from congressional control. The destruction of decades of construction in Education, Culture, Foreign Relations, Environment, Science, and other areas serves as fuel for this symbolic and practical war against those who produce dissonant ideas and values.
STRATEGIES FOR ENHANCING INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) USAGE IN HOME ECONOMICS INSTRUCTIONAL PROCESS IN THE SECONDARY SCHOOLS OF ODIGBO LOCAL GOVERNMENT AREA OF ONDO STATE (JoSVTE, 8(1): 112-28, 2020)
Creators: name: Oluwagbemileke, Feranmi Boluwatife
Publisher: name: figshare
Year: 2023
Subjects: Vocational education and training curriculum and pedagogy
Secondary education
Communication technology and digital media studies

description: This research was carried out to identify the strategies for enhancing Information and Communication Technology (ICT) usage in Home Economics instructional process in the Secondary Schools in Odigbo Local Government Area of Ondo State. Descriptive Survey research design was adopted for the study. Two forms of questionnaires were administered on a total of 200 respondents (8 teachers and 192 students) who were randomly and proportionally sampled for the study. Data collected were analyzed with descriptive statistics (frequency count, percentage and mean) to answer the three research questions, while the postulated hypothesis was subjected to t-test. The findings showed that the use of ICT in teaching-learning process is highly preferred among the Home Economics teachers and secondary school students, though there are militating factors such as lack and poor condition of ICT infrastructures, and electricity interruptions. It was also found out that the mean opinion of the teachers are not significantly different from that of the students on the preference of ICT usage in Home Economics instruction (df=10, t-cal=0.38,t-tab=1.81). It was recommended that enlightenment forums on ICT usage should be organized, and that ICT usage should be made compulsory and properly funded in secondary schools.
INFERENCE ON THE INVERSE POWER BURR-HATKE DISTRIBUTION UNDER TYPE II CENSORING
Creators: name: Pavitra Kumari
name: Kumar, Vinay
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Burr-Hatke Distribution
Inverse Power BurrHatke Distribution
Type II censoring
Bayesian estimation
Lindley’s Approximation technique

description: There are many real-life situations, where data require probability distribution function which have decreasing or upside-down bathtub (UBT) shaped failure rate function. The inverse power burr hatke distribution consists both decreasing and UBT shaped failure rate functions. Here, we address the different estimation methods of the parameter and reliability characteristics of the inverse Pareto distribution from both classical and Bayesian approaches. We consider classical estimation procedures to estimate the unknown parameter of inverse power burr-hatke distribution, such as maximum likelihood. Also, we consider Bayesian estimation using squared error loss function based joint priors. The Monte Carlo simulations are performed to compare the performances of the obtained estimators in mean square error sense. Finally, the flexibility of the proposed distribution is illustrated empirically using one real-life datasets. The analyzed data shows that the introduced distribution provides a superior fit than some important competing distributions such as the Weibull, inverse Pareto and Burr-Hatke distributions.
M5.1 - Reference collection of test data sets
Creators: name: Huber, Robert
name: Verburg, Maaike
Publisher: name: Zenodo
Year: 2023
Subjects: FAIR
FAIR data
FAIR-IMPACT
FAIR data assessment
Automated assessement tools
F-UJI
Reference collection
Datasets
Verification
Benchmarking

description: This report describes the FAIR-IMPACT Milestone M5.1 - Reference collection of test data sets, one of the outputs of Work Package 5 - Metrics, certification, and guidelines. The Milestone consists of a collection of links to social science data sets. These are intended to verify the implementation of the discipline-specific metrics for the social sciences which are also being developed in the same Work Package. Note: The collection is currently available internally for the project partners only. After the initial testing with F-UJI and further curation of the collection, the collection will also become available to the larger public.
Prevalence and Predictors of Major Depression in HIV-Infected Patients on Antiretroviral Therapy in Bamenda, a Semi-Urban Center in Cameroon
Creators: name: O’Donnell, Julie
name: Pence, Brian W.
name: Gaynes, Bradley N.
name: Atashili, Julius
name: Kats, Dmitry
name: Ndumbe, Peter M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Recent blue-ribbon panel reports have concluded that HIV treatment programs in less wealthy countries must integrate mental health identification and treatment into normal HIV clinical care and that research on mental health and HIV in these settings should be a high priority. We assessed the epidemiology of depression in HIV patients on antiretroviral therapy in a small urban setting in Cameroon by administering a structured interview for depression to 400 patients consecutively attending the Bamenda Regional Hospital AIDS Treatment Center. One in five participants met lifetime criteria for MDD, and 7% had MDD within the prior year. Only 33% had ever spoken with a health professional about depression, and 12% reported ever having received depression treatment that was helpful or effective. Over 2/3 with past-year MDD had severe or very severe episodes. The number of prior depressive episodes and the number of HIV symptoms were the strongest predictors of past-year MDD. The prevalence of MDD in Cameroon is as high as that of other HIV-associated conditions, such as tuberculosis and Hepatitis B virus, whose care is incorporated into World Health Organization guidelines. The management of depression needs to be incorporated in HIV-care guidelines in Cameroon and other similar settings.
Survey # 58
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Current political problems (1); attitudes toward President (1); satisfaction with Chancellor Adenauer’s policies (1); inflation (2); carnival (4); fear of war (1); German army (1); German participation in West European defense pact (1); European integration (2); cooperation with USA (4); cooperation with France (1); consumption patterns (1); smoking habits (2); cigarette brands (11); political priorities (1); East German refugees (1); clocks and watches (20); knowledge about Korea (2); constitutional court (2); freedom of speech (1); electoral system (2); soup product brands (3); cotton ball brands (10).