cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sting agonist mitigates experimental autoimmune encephalomyelitis by stimulating type i ifn-dependent and -independent immune-regulatory pathways
Creators: name: Markovic-Plese S
name: Ting J.P.-Y
name: Batty C.J
name: Gallovic M.D
name: Ainslie K.M
name: Deng M
name: Tam J.W
name: Williams J
name: Matsushima G.K
name: Bachelder E.M
name: Thamilarasan M
name: Chou W.-C
name: Johnson B.M
name: Gibson S.A
name: Uchimura T
Publisher: name: American Association of Immunologists
Year: 2021

description: The cGAS-cyclic GMP-AMP (cGAMP)-stimulator of IFN genes (STING) pathway induces a powerful type I IFN (IFN-I) response and is a prime candidate for augmenting immunity in cancer immunotherapy and vaccines. IFN-I also has immuneregulatory functions manifested in several autoimmune diseases and is a first-line therapy for relapsing-remitting multiple sclerosis. However, it is only moderately effective and can induce adverse effects and neutralizing Abs in recipients. Targeting cGAMP in autoimmunity is unexplored and represents a challenge because of the intracellular location of its receptor, STING. We used microparticle (MP)-encapsulated cGAMP to increase cellular delivery, achieve dose sparing, and reduce potential toxicity. In the C57BL/6 experimental allergic encephalomyelitis (EAE) model, cGAMP encapsulated in MPs (cGAMP MPs) administered therapeutically protected mice from EAE in a STING-dependent fashion, whereas soluble cGAMP was ineffective. Protection was also observed in a relapsing-remitting model. Importantly, cGAMP MPs protected against EAE at the peak of disease and were more effective than rIFN-b. Mechanistically, cGAMP MPs showed both IFN-I-dependent and -independent immunosuppressive effects. Furthermore, it induced the immunosuppressive cytokine IL-27 without requiring IFN-I. This augmented IL-10 expression through activated ERK and CREB. IL-27 and subsequent IL-10 were the most important cytokines to mitigate autoreactivity. Critically, cGAMP MPs promoted IFN-I as well as the immunoregulatory cytokines IL-27 and IL-10 in PBMCs from relapsing-remitting multiple sclerosis patients. Collectively, this study reveals a previously unappreciated immune-regulatory effect of cGAMP that can be harnessed to restrain T cell autoreactivity.
Emarginula Lamarck 1801
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Lepetellida
Fissurellidae
Emarginula

description: Genus Emarginula Lamarck, 1801
Type species. Emarginula conica Lamarck, 1801 [= Emarginula fissura (Linnaeus, 1758)] (Lamarck 1801: 69), by monotypy. Present-day, Europe.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 24, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Emarginula octaviana Coen 1939
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Lepetellida
Fissurellidae
Emarginula
Emarginula octaviana

description: Emarginula octaviana Coen, 1939
Plate 1 B 1 -B 2
Emarginula elongata, Costa 1829: 10 (non Defrance, 1819; non G.B. Sowerby I, 1823; non Gray,1825).
Emarginula elongata, Costa 1830: 10 (non Defrance, 1819; non G.B. Sowerby I, 1823; non Gray,1825).
Emarginula Ornata Millet 1854: 166 (nomen nudum).
Emarginula ornata Millet 1864: 599.
* Emarginula octaviana Coen 1939: 71.
Emarginula elongata da Costa — Glibert 1949: 20, pl.1, fig. 9.
Emarginula elongata Costa, 1829 — Brébion 1964: 58, pl. 1, figs. 7, 8.
Emarginula octaviana Coen, 1939 — Piani 1984: 206, figs. 26-36.
Emarginula octaviana Coen, 1939 — Giannuzzi-Savelli et al. 1994: 46, fig. 77
Emarginula octaviana Coen, 1939 — Chirli & Linse 2011: 32, pl. 3, fig. 3.
Emarginula octaviana Coen, 1939 —Hernández et al. 2011: 59, figs. 9H-J.
Emarginula octaviana Coen, 1939 — Ceulemans et al. 2016a: 57, pl. 2, fig. 3 (cum syn.).
Emarginula octaviana Coen, 1939 — Chirli & Forli 2017: 20, pl. 3, fig. D.
Emarginula octaviana Coen, 1939 — Landau et al. 2017: 86, pl. 9, figs. 1-2.
Santa Maria material examined. Maximum height 1.8 mm, width 3.0 mm. DBUA-F 487-1 (2), Ponta do Castelo, Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Description. Azorean specimen juvenile, not apt for description.
Discussion. The Azorean specimens represent a juvenile but shows the salient characteristics of the species; the long elongated profile, coarse reticulate sculpture, and most importantly the lamellae on the selenizone, which are relatively coarse and rise above the level of the reticulate sculpture on lateral view. For further comparison, see Ceulemans et al. (2016: 58).
Distribution. Upper Miocene: Atlantic (Tortonian), NW France (Millet 1854, 1865; Brébion 1964; Landau et al. 2017). Lower Pliocene: Atlantic, NW France (Brébion 1964; Ceulemans et al. 2016), Santa Maria Island, Azores (this paper). Upper Pliocene-Lower Pleistocene: NW France (Brébion 1964). Lower Pleistocene: central Mediterranean (Chirli & Forli 2017); eastern Mediterranean (Chirli & Linse 2011). Present-day: Atlantic Canaries (Hernández et al. 2011), Portugal, Morocco and Mediterranean (Poppe & Goto 1992).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 24, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Bolma Risso 1826
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Turbinidae
Bolma

description: Genus Bolma Risso, 1826
Type species. Turbo rugosus Linné, 1767 (Risso 1826: 117), by monotypy. Present-day, Mediterranean.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 25, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant
Creators: name: Pena E.S
name: Bachelder E.M
name: Sempowski G.D
name: Ting J.P.-Y
name: Junkins R.D
name: Sandor A.M
name: Gallovic M.D
name: Arwood L.C
name: Sahm R.A
name: Mason A.K
name: Sample C.J
name: Ainslie K.M
Publisher: name: Elsevier B.V.
Year: 2022

description: The current pandemic highlights the need for effective vaccines against respiratory viruses. An ideal vaccine should induce robust and long-lasting responses with high manufacturing scalability. We use an adjuvant comprised of a Stimulator of Interferon Genes (STING) agonist incorporated in a scalable microparticle platform to achieve durable protection against the influenza virus. This formulation overcomes the challenges presented by the cytosolic localization of STING and the hydrophilicity of its agonists. We evaluated a monoaxial formulation of polymeric acetalated dextran microparticles (MPs) to deliver the STING agonist cyclic GMP-AMP (cGAMP) which achieved >10× dose-sparing effects compared to other published work. Efficacy was evaluated in ferrets, a larger animal model of choice for influenza vaccines. cGAMP MPs with recombinant hemagglutinin reduced viral shedding and improved vaccine outcomes compared to a seasonal influenza vaccine. Importantly, sustained protection against a lethal influenza infection was detected a year after a single dose of the vaccine-adjuvant.
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity
Creators: name: Wang Y
name: Major M.B
name: Simon J.M
name: Mei L
name: Cloer E.W
name: Cook J.G
name: Hepperla A.J
name: Liu P
name: Zhang J
name: Du H
name: Tan X
name: Dotti G
name: Zhou X
name: Zhu Z
Publisher: name: John Wiley and Sons Inc
Year: 2023

description: STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune-friendly microenvironment to prevent tumorigenesis. However, if and how STING exerts innate immunity-independent function remains elusive. Here, the authors report that STING expression is increased in renal cell carcinoma (RCC) patients and governs tumor growth through non-canonical innate immune signaling involving mitochondrial ROS maintenance and calcium homeostasis. Mitochondrial voltage-dependent anion channel VDAC2 is identified as a new STING binding partner. STING depletion potentiates VDAC2/GRP75-mediated MERC (mitochondria-ER contact) formation to increase mitochondrial ROS/calcium levels, impairs mitochondria function, and suppresses mTORC1/S6K signaling leading to RCC growth retardation. STING interaction with VDAC2 occurs through STING-C88/C91 palmitoylation and inhibiting STING palmitoyl-transferases ZDHHCs by 2-BP significantly impedes RCC cell growth alone or in combination with sorafenib. Together, these studies reveal an innate immunity-independent function of STING in regulating mitochondrial function and growth in RCC, providing a rationale to target the STING/VDAC2 interaction in treating RCC.
Elasmoproctiella Kolebinova and Vercammen-Grandjean 1978
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Walchiidae
Elasmoproctiella

description: Subgenus Elasmoproctiella Kolebinova and Vercammen-Grandjean, 1978
Schoengastiella (Elasmoproctiella) Kolebinova and Vercammen-Grandjean, 1978
Elasmoproctiella, Wen 1999 a
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Turbo Linnaeus 1758
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Turbinidae
Turbo

description: Genus Turbo Linnaeus, 1758
Type species. Turbo petholatus Linnaeus, 1758 (Linnaeus 1758: 761), by subsequent designation (Montfort 1810). Present-day, Indo-Pacific.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 25, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
MODALLIKNING NAZARIY ASOSLARI VA UNING FALSAFIY, MANTIQIY, TILSHUNOSLIK NUQTAYI NAZARIDAN TAHLILI
Creators: name: Turakulova, Dilafruz
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola modallik tushunchasining nazariy asoslarini o‘rganishga bag‘ishlangan. Maqolada modallikning falsafiy, mantiqiy va lingvistik kategoriyalar sifatida rivojlanishi, uning tarixiy asoslari va zamonaviy yondashuvlari muhokama qilinadi. Modallikning epistemik, deontik va dinamik turlari o‘rtasidagi farqlar tahlil qilinib, ularning subyektiv va obyektiv xususiyatlari ko‘rsatib beriladi. Xususan, epistemik modallikning bilim, e’tiqod va taxminlarga asoslangan fikrlar bilan bog‘liqligi, shuningdek, ijtimoiy va madaniy omillar ta’siri o‘rganiladi. Maqolada Aristotel va I.Kantning modallikka oid nazariyalari, shuningdek, zamonaviy lingvistik tadqiqotlarning, jumladan, Palmer, Lyons va Hallidey tomonidan ilgari surilgan qarashlar tahlil qilinadi.
STING-induced regulatory B cells compromise NK function in cancer immunity
Creators: name: Cui Y
name: Yang N
name: Deng M
name: Wrobel J.A
name: Mirlekar B
name: Vincent B.G
name: Tan X
name: Li S
name: Ting J.P.-Y
name: Entwistle S
name: Brickey W.J
name: Song D
name: Pylayeva-Gupta Y
name: Johnson B.M
name: Li W
name: Gale Jr., M
Publisher: name: Nature Research
Year: 2022

description: An immunosuppressive tumour microenvironment is a major obstacle in the control of pancreatic and other solid cancers1–3. Agonists of the stimulator of interferon genes (STING) protein trigger inflammatory innate immune responses to potentially overcome tumour immunosuppression4. Although these agonists hold promise as potential cancer therapies5, tumour resistance to STING monotherapy has emerged in clinical trials and the mechanism(s) is unclear5–7. Here we show that the administration of five distinct STING agonists, including cGAMP, results in an expansion of human and mouse interleukin (IL)-35+ regulatory B cells in pancreatic cancer. Mechanistically, cGAMP drives expression of IL-35 by B cells in an IRF3-dependent but type I interferon-independent manner. In several preclinical cancer models, the loss of STING signalling in B cells increases tumour control. Furthermore, anti-IL-35 blockade or genetic ablation of IL-35 in B cells also reduces tumour growth. Unexpectedly, the STING–IL-35 axis in B cells reduces proliferation of natural killer (NK) cells and attenuates the NK-driven anti-tumour response. These findings reveal an intrinsic barrier to systemic STING agonist monotherapy and provide a combinatorial strategy to overcome immunosuppression in tumours.
Посилення спроможності профспілок шляхом утвердження європейських стандартів соціального діалогу в умовах війни та повоєнного відновлення України.
Creators: name: Petroye, Olha
Publisher: name: Zenodo
Year: 2025
Subjects: Спроможність профспілок; соціальний діалог; національні моделі; ефуктивність; європейські стандарти.

description: Презентація висвітлює проблеми соціально-економіного розвитку України. Автор обгрунтовує, що низький рівень соціальних стандартів та зниження прав працівників в Україні  значною мірою зумовлені  низькою спроможністю профспілок до рівноправного соціального діалогу з роботодавцями та органами державної влади. В презентації автор розкриває зміст соціального діалогу як механізму посилення спроможності профспілок України в умовах війни та повоєнного відновлення  країни, обгрунтовує  необхідність імплементації  новітніх європейських стандартів соціального діалогу як умови забезпечення євроінтеграційних цілей України.
Nerita Linnaeus 1758
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Cycloneritida
Neritidae
Nerita

description: Genus Nerita Linnaeus, 1758
Type species. Nerita peloronta Linnaeus, 1758 (Linnaeus 1758: 776), by subsequent designation (Montfort 1810). Present-day, Caribbean.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 27, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
Creators: name: Verhage M
name: Liu F
name: Protze J
name: Koopmans F
name: Li K.W
name: Gonzalez-Lozano M.A
name: Krause G
name: Smit A.B
name: Sullivan P.F
Publisher: name: American Association for the Advancement of Science
Year: 2020

description: Synaptic transmission is the predominant form of communication in the brain. It requires functionally specialized molecular machineries constituted by thousands of interacting synaptic proteins. Here, we made use of recent advances in cross-linking mass spectrometry (XL-MS) in combination with biochemical and computational approaches to reveal the architecture and assembly of synaptic protein complexes from mouse brain hippocampus and cerebellum. We obtained 11,999 unique lysine-lysine cross-links, comprising connections within and between 2362 proteins. This extensive collection was the basis to identify novel protein partners, to model protein conformational dynamics, and to delineate within and between protein interactions of main synaptic constituents, such as Camk2, the AMPA-type glutamate receptor, and associated proteins. Using XL-MS, we generated a protein interaction resource that we made easily accessible via a web-based platform (http://xlink.cncr.nl) to provide new entries into exploration of all protein interactions identified.
title: ÐÐµÑÐ¾Ð´Ñ Ð¸ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð¼ÐµÑÐ½ÑÑ Ð½ÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½ÑÑ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð²
title: Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: Ð ÑÑÑÐºÐ¾Ð², ÐÐ»ÐµÐ³
name: Ð¡Ð°ÑÐ°Ð´Ð¶Ð¸ÑÐ²Ð¸Ð»Ð¸, Ð¡ÐµÑÐ³ÐµÐ¹
name: Ð£ÑÑÐ¸Ð½Ð¾Ð², Ð¡ÐµÑÐ³ÐµÐ¹
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2024
Subjects: Ð ÑÐ´Ñ (Ð¼Ð°Ñ.) Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐµ

description: ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¸ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð². ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð° ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð². Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¸Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸, Ð´Ð¾ÑÑÐ¾Ð¸Ð½ÑÑÐ²Ð° Ð¸ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐºÐ¸ Ð¿ÑÐ¸ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð¼ÐµÑÐ½ÑÑ Ð½ÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½ÑÑ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð². ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ ÑÑÐ¸ Ð¼ÐµÑÐ¾Ð´Ð° Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð¼ÐµÑÐ½ÑÑ Ð½ÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½ÑÑ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð², Ð½Ð° Ð¸Ñ Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ. ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÐµ Ð½Ð° Ð¸Ñ Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑ ÑÐ½Ð¸Ð¶Ð°ÑÑ Ð¿Ð¾Ð³ÑÐµÑÐ½Ð¾ÑÑÑ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð¼ÐµÑÐ½Ð¾Ð³Ð¾ Ð½ÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½Ð¾Ð³Ð¾ Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ´Ð° Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð»ÑÑÑÐ¸Ñ Ð¸Ð· ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹, Ð² ÑÐ°ÑÑÐ½Ð¾ÑÑÐ¸ Ð½Ð°Ð¸Ð²Ð½ÑÑ, Ð°Ð²ÑÐ¾ÑÐµÐ³ÑÐµÑÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¸ Ð½ÐµÐ¹ÑÐ¾ÑÐµÑÐµÐ²ÑÑ Ð½Ð° ÐºÑÐ°ÑÐºÐ¾ÑÑÐ¾ÑÐ½Ð¾Ð¼ Ð³Ð¾ÑÐ¸Ð·Ð¾Ð½ÑÐµ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ.
Stopping pandemics before they start: Lessons learned from SARS-CoV-2
Creators: name: Baric R.S
name: Saphire E.O
name: Edwards A.M
name: Ulmer J.B
Publisher: name: American Association for the Advancement of Science
Year: 2022

description: The vaccine and drug discovery responses to COVID-19 have worked far better than could have been imagined. Yet by the end of 2021, more than 5 million people had died, and the pandemic continues to evolve and rage globally. This Review will describe how each of the vaccines, antibody therapies, and antiviral drugs that have been approved to date were built on decades of investment in technology and basic science. We will caution that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has so far proven a straightforward test of our pandemic preparedness, and we will recommend steps we should undertake now to prepare for, to minimize the effects of, and ideally to prevent future pandemics. Other Reviews in this series describe the interactions of SARS-CoV-2 with the immune system and those therapies that target the host response to infection.
Thoonchus Cobb 1920
Creators: name: Zograf, Julia K.
name: Pavlyuk, Olga N.
name: Trebukhova, Yulia A.
name: Baoquan, Li
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Enoplea
Enoplida
Enchelidiidae
Thoonchus

description: Genus Thoonchus Cobb, 1920
Diagnosis (Smol et al. 2014). Enchelidiidae. Six lips. Inner labial sensilla papilliform or setiform. Buccal cavity large with heavily sclerotized walls, 1 to 1.5 times as long as broad. Three teeth, right ventrosublateral tooth largest; several rows of denticles present. Amphid large and situated either at the level of the buccal cavity or behind. Secretory-excretory pore anterior or posterior to buccal cavity. Spicules short and arcuate, gubernaculum with expanded corpus and with or without apophysis. One or two precloacal supplement(s) and papillae present or absent. Marine.
Type species:
Thoonchus ferox Cobb, 1920
Other species:
Thoonchus covidus sp. nov.
Thoonchus inermis Gerlach, 1953
Thoonchus longisetosus Keppner, 1988
Doubtful species:
Thoonchus giganticus Belogurova, Belogurov & Khamula, 1986
description: Published as part of Zograf, Julia K., Pavlyuk, Olga N., Trebukhova, Yulia A. & Baoquan, Li, 2020, New species of Thoonchus (Enoplida, Enchelidiidae) from the Yellow Sea and redescription of T. giganticus Belogurova et al., 1986, pp. 239-252 in Zootaxa 4845 (2) on pages 240-241, DOI: 10.11646/zootaxa.4845.2.5, http://zenodo.org/record/4486679
KVADRAT TENGLAMA VA UNING YECHIMLARI
Creators: name: Shomurodova, Gulrux
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada kvadrat tenglama va uning yechimlari haqida batafsil ma'lumotlar berilgan. Maqolada kvadrat tenglama, uning turlari, va yechish usullari to'g'risida batafsil bayon etilgan. Kvadrat tenglama o'quvchilarga matematikadan ko'plab muammolarni yechishda qo'llaniladigan zarur vosita bo'lib, turli sohalarda ishlatiladi. Shuningdek, maqolada kvadrat tenglamalarni yechishda qo'llaniladigan 10 ta usul ko'rsatilgan. Har bir yechim usuli matematik jihatdan tushuntirilgan va qo'llaniladigan misollar keltirilgan.
Stories about HPV vaccine in social media, traditional media, and conversations
Creators: name: Shah P.D
name: Margolis M.A
name: Gilkey M.B
name: Calo W.A
name: Brewer N.T
Publisher: name: Academic Press Inc.
Year: 2019

description: How stories from media and social interactions shape parents' HPV vaccination decisions is poorly understood. We sought to characterize parents' exposure to such stories, as well as associations between story exposure and vaccination behavior. Study participants were 1263 parents of U.S. adolescents who had not yet completed the HPV vaccine series. In 2017, these parents completed an online survey about whether they had heard stories of people who were harmed by HPV vaccine or who got diseases HPV vaccine could have prevented. Almost half of parents had heard HPV vaccine stories, which were about vaccine harms only (19%), vaccine preventable diseases only (11%), or both (15%). Stories of harms more often came from social and traditional media; stories of preventable diseases more often came from conversations (all p < 0.01). Parents who heard only stories about harms were less likely than those who heard no stories to have initiated HPV vaccination (23% vs. 33%, aOR:0.48; 95% CI:0.33:0.69). They were more likely to have delayed (79% vs. 66%, aOR:2.00; 95% CI:1.09:3.71) or refused (72% vs. 24%, aOR:8.87; 95% CI:4.09:19.25) HPV vaccination. Exposure to both stories about harms and preventable diseases was similarly associated with initiation, delay and refusal. Exposure to only stories about preventable diseases was not associated with initiation, delay or refusal. In conclusion, stories of HPV vaccine harms may be associated more strongly with vaccination behavior than stories of HPV vaccine preventable diseases. Communication campaigns should consider strategies to elevate stories of preventable diseases in social and traditional media.
Strategies targeting tumor immune and stromal microenvironment and their clinical relevance
Creators: name: Hu, M
name: Huang, L
Publisher: name: Elsevier B.V.
Year: 2022

description: The critical role of tumor microenvironment (TME) in tumor initiation and development has been well-recognized after more than a century of studies. Numerous therapeutic approaches targeting TME are rapidly developed including those leveraging nanotechnology, which have been further accelerated since the emergence of immune checkpoint blockade therapies in the past decade. While there are many reviews focusing on TME remodeling therapies via drug delivery and engineering strategies in animal models, state-of-the-art evaluation of clinical development states of TME-targeted therapeutics is rarely found. Here, we illustrate opportunities for integrating nano-delivery system for the development of TME-specific therapeutic regimen, followed by a comprehensive summary of the most up to date approved or clinically evaluated therapeutics targeting cellular and extracellular components within tumor immune and stromal microenvironment, including small molecule and monoclonal antibody drugs as well as nanomedicines. In the end, we also discuss challenges and possible solutions for clinical translation of TME-targeted nanomedicines.
Nerita funata Dujardin 1837
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Cycloneritida
Neritidae
Nerita
Nerita funata

description: Nerita cf. funata Dujardin, 1837
Plate 1 E 1 -E 3
cf. * Nerita funata Dujardin 1837: 281, pl. 19, fig. 14.
? Nerita Plutonis Bast. —Bronn in Reiss 1862: 33.
? Nerita Plutonis Bast. — Mayer 1864: 63, 93.
cf. Nerita (Theliostyla) funata Dujardin, 1837 — Glibert 1949: 69, pl. 4, fig. 8.
Santa Maria material examined. Maximum height 4.0 mm, width 6.0 mm. DBUA-F 917-1 (1), Ponta do Castelo, Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Description. Apical fragment with completely flattened spire. Teleoconch bearing about 22 subequal rounded ribs, slightly narrower than their interspaces, shoulder cord slightly strengthened.
Discussion. Mayer (1864: 63) recorded two specimens from Bocca do Cré (= Cré), Santa Maria Island, without indicating their size. The Azorean material is very incomplete, but clearly represents a Nerita species of the Theliostyla M̂rch, 1852 group. Two species occurred along the French Atlantic Frontage during the Miocene. Nerita plutonis de Basterot, 1825, from the Lower Miocene, has relatively coarse cords of irregular strength and N. funata Dujardin, 1837, from the Middle Miocene, has finer, subequal cords. Lozouet et al. (2001: 20) considered the Lower Miocene records of N. funata in Cossmann & Peyrot (1917: pl. 7, figs. 77-82) to represent N. plutonis.
The fragment at hand from Santa Maria Island, has numerous subequal ribs more closely similar to those seen in N. funata than N. plutonis. However, we hesitate to make a definitive identification based on this very incomplete specimen. The historical Azorean specimens identified by Bronn in Reiss (1862: 33) and Mayer (1864: 63, 93) as N. plutonis are likely to represent the same species.
This group of Nerita species with spiral cords is not represented in the Pliocene Mediterranean. Today, the group is represented in the eastern Atlantic by N. senegalensis Gmelin, 1791, distributed from the Cabo Verde Islands to Angola, whereas in the western Atlantic a total of five species are reported, four of them from Bermuda, the Gulf of Mexico and the Caribbean (Nerita fulgurans Gmelin, 1791; Nerita peloronta Linnaeus, 1758; Nerita tessellata Gmelin, 1791; and Nerita versicolor Gmelin, 1791), and one species endemic to Brazil (Nerita chlorostoma Lamarck, 1816). Nerita senegalensis differs in having flattened cords of irregular width, separated by narrow grooves.
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (?Bronn in Reiss 1862;? Mayer 1864; this paper).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on pages 27-28, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Schoengastiella (Elasmoproctiella) arona
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Walchiidae
Schoengastiella
Schoengastiella arona

description: Schoengastiella (Elasmoproctiella) arona (Traub and Evans, 1954):
ORI
Gahrliepia (Schoengastiella) arona Traub and Evans, 1954
Schoengastiella (Schoengastiella) arona, Vercammen-Grandjean 1968c [birella group]
Schoengastiella (Elasmoproctiella) arona, Kolebinova &Vercammen-Grandjean 1978
Elasmoproctiella arona, Wen 1999 a
Schoengastiella arona, Stekolnikov 2021
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Structural and functional connectome relationships in early childhood
Creators: name: Styner, M.A
name: Gao, W
name: Cornea, E
name: Hong, Y
name: Bagonis, M
name: Girault, J.B
name: Prieto, J.C
name: Gilmore, J.H
name: Chen, H
name: Kim, S.H
name: Foster, M
Publisher: name: Elsevier Ltd
Year: 2023

description: There is strong evidence that the functional connectome is highly related to the white matter connectome in older children and adults, though little is known about structure-function relationships in early childhood. We investigated the development of cortical structure-function coupling in children longitudinally scanned at 1, 2, 4, and 6 years of age (N = 360) and in a comparison sample of adults (N = 89). We also applied a novel graph convolutional neural network-based deep learning model with a new loss function to better capture inter-subject heterogeneity and predict an individual's functional connectivity from the corresponding structural connectivity. We found regional patterns of structure-function coupling in early childhood that were consistent with adult patterns. In addition, our deep learning model improved the prediction of individual functional connectivity from its structural counterpart compared to existing models.
Thericium Monterosato 1890
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neotaenioglossa
Cerithiidae
Thericium

description: Genus Thericium Monterosato, 1890
Type species. Cerithium vulgatum Bruguière, 1792, by original designation (Monterosato 1890: 163). Present-day, Mediterranean.
Note. Most authors have placed these Atlantic cerithiid species in the genus Cerithium Bruguière, 1789. Landau et al. (2004a: 5) argued that true Cerithium (sensu stricto) was an Indo-Pacific genus, characterised by a flaring outer lip with a tooth-like extension abapically projecting over the anterior siphonal canal, and a relatively longer siphonal canal. We follow those authors in using Thericium Monterosato, 1890, at full genus level.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 28, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment
Creators: name: Sadreyev R.I.
name: Sun R
name: Jia L
name: Jia J
name: DeLeo A.B
name: Ferrone S.
name: Cattaneo G
name: Fan S
name: Liu F
name: Li Y
name: Zhang H
name: Wong L.P.
name: Sun F
name: Wang Y
name: Arya S
name: Boland G.M.
name: Dal E
name: Zhang Y
name: Taghian A.G
name: Ventin M
name: Dotti G
name: Kehlmann A.M
name: Jounaidi Y
name: Huang P
name: Zheng H
name: Yu L
name: Wang X.
name: Chen F
name: Yang J.
name: Drum D.L
name: Maccalli C
name: Ferrone C.R
name: Wang C
name: Isakoff S.J
Publisher: name: Nature Research
Year: 2023

description: The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target antigen heterogeneity or antigen loss of target cancer cells, and immunosuppressive tumor microenvironment (TME). Here we describe a broadly applicable nongenetic approach that simultaneously addresses the multiple challenges of CAR T as a therapy for solid tumors. The approach reprograms CAR T cells by exposing them to stressed target cancer cells which have been exposed to the cell stress inducer disulfiram (DSF) and copper (Cu)(DSF/Cu) plus ionizing irradiation (IR). The reprogrammed CAR T cells acquire early memory-like characteristics, potent cytotoxicity, enhanced in vivo expansion, persistence, and decreased exhaustion. Tumors stressed by DSF/Cu and IR also reprogram and reverse the immunosuppressive TME in humanized mice. The reprogrammed CAR T cells, derived from peripheral blood mononuclear cells of healthy donors or metastatic female breast cancer patients, induce robust, sustained memory and curative anti-solid tumor responses in multiple xenograft mouse models, establishing proof of concept for empowering CAR T by stressing tumor as a promising therapy for solid tumors.
ZAMONAVIY O'QITUVCHI ETIKASI
Creators: name: Ziyadullayeva, Nigora
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada zamonaviy o‘qituvchining kasbiy faoliyatida etik me’yorlarning tutgan o‘rni va ahamiyati keng yoritilgan. O‘qituvchi nafaqat ta’lim beruvchi, balki o‘quvchilar uchun axloqiy namuna sifatida qabul qilinishi kerakligi ta’kidlangan. Ushbu maqola orqali zamonaviy ta’lim jarayonida o‘qituvchilarning axloqiy tamoyillari, ularning kasbiy faoliyatdagi mas’uliyati, shaxsiy xususiyatlari va ta’lim sifatiga ta’siri batafsil tahlil qilinadi. Shuningdek, o‘qituvchi va jamiyat o‘rtasidagi o‘zaro aloqalar, zamonaviy texnologiyalarning o‘qituvchi etikasi bilan bog‘liq muammolari va yechimlari ham ko‘rib chiqilgan.
Structural genomics of the human dopamine receptor system
Creators: name: Wang, Y
name: Mao, C
name: Huang, X.-P
name: Zhang, Y
name: Yin, W
name: Liu, Y.-F
name: Zhuang, Y
name: Jiang, Y
name: Li, H
name: Xu, P
name: Huang, S
name: Zhang, Y
name: Xu, H.E
name: Krumm, B.E
name: He, X
name: Roth, B.L
Publisher: name: Springer Nature
Year: 2023

description: The dopaminergic system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system (CNS); and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders, including Parkinson’s Disease (PD) and schizophrenia. Here, we report cryo-EM structures of all five subtypes of human dopamine receptors in complex with G protein and bound to the pan-agonist, rotigotine, which is used to treat PD and restless legs syndrome. The structures reveal the basis of rotigotine recognition in different dopamine receptors. Structural analysis together with functional assays illuminate determinants of ligand polypharmacology and selectivity. The structures also uncover the mechanisms of dopamine receptor activation, unique structural features among the five receptor subtypes, and the basis of G protein coupling specificity. Our work provides a comprehensive set of structural templates for the rational design of specific ligands to treat CNS diseases targeting the dopaminergic system.
Bittium Gray 1847
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Cerithiidae
Bittium

description: Genus Bittium Gray, 1847
Type species. Strombiformis reticulatum da Costa, 1778 (Gray 1847a: 70), by subsequent designation (Gray, 1847b [November]). Present-day, Europe.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 31, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Thoonchus giganticus Belogurova 1986
Creators: name: Zograf, Julia K.
name: Pavlyuk, Olga N.
name: Trebukhova, Yulia A.
name: Baoquan, Li
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Enoplea
Enoplida
Enchelidiidae
Thoonchus
Thoonchus giganticus

description: Thoonchus giganticus Belogurova et al., 1986
(Fig 6, Table 1)
Redescription. Body fusiform, narrowing to the head end, 6905 µm long. Width at midbody 362 µm. Head end blunt. Inner and outer labial sensilla indistinct. Cephalic setae 9 µm long. Amphids pocket-shaped, situated at the base of the buccal cavity. Buccal cavity small, 31 µm deep. Three unequal teeth in the buccal cavity. The biggest right subventral tooth 25 µm long (Fig. 6B). About 5 complete irregular circles of small sharp denticles present. Pharynx long, muscular, 1566 µm long. Secretory-excretory system not visible. Spicules curved, cephalated, 553 µm or ca 5 cloacal diameters long (Fig. 6D). Gebernaculum stick-shaped, without apophysis. Supplements absent. A ventral row of 7 papilla anterior to cloaca (Fig. 6E). Two ventral setae immediately anterior to cloaca. Tail conicocilindrical, 246 µm or 2.3 cloacal diameters long (Fig. 6C).
Remarks. Belogurova and co-authors (1986) described Thoonchus giganticus from the Tatar Strait (Fig. 7). Authors placed this species among Thoonchus based on the presence of three teeth and small denticles in the buccal cavity and the absence of supplements in male. Later on, Keppner (1988) mentioned that the shape of buccal cavity, teeth, and male genital apparatus deviate significantly from that of Thoonchus. He also noted that this species is difficult to place within existing genera of Enchelidiidae or erect a new genus for it. Therefore, Thoonchus giganticus might be considered of doubtful generic assignment (Keppner, 1988). We agree that T. giganticus deviates greatly from other Thoonchus species, but we propose considering it incertae sedis till the new genus is established.
description: Published as part of Zograf, Julia K., Pavlyuk, Olga N., Trebukhova, Yulia A. & Baoquan, Li, 2020, New species of Thoonchus (Enoplida, Enchelidiidae) from the Yellow Sea and redescription of T. giganticus Belogurova et al., 1986, pp. 239-252 in Zootaxa 4845 (2) on pages 248-249, DOI: 10.11646/zootaxa.4845.2.5, http://zenodo.org/record/4486679
Structural insights from G-protein-coupled receptor complexes enable the rational engineering of improved light-activated designer receptors
Creators: name: Roth B.L
name: Kapolka N.J
Publisher: name: Cell Press
Year: 2022

description: Engineered signaling proteins permit precise modulation of cell signaling networks and are valuable tools for basic and translational research. In this issue of Structure, Tichy and colleagues leverage high-resolution GPCR-G protein complex structures to rationally design improved light-activated chimeric GPCRs (termed OptoXRs) with increased sensitivity and tunable signaling features.
Neoliomera Odhner 1925
Creators: name: P. - H
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Xanthidae
Neoliomera

description: Neoliomera Odhner, 1925
Type species. Zozymus pubescens H. Milne Edwards, 1834, by original designation; gender feminine.
description: Published as part of P. - H & Ng, Peter K. L., 2014, A new species of Neoliomera Odhner, 1925, from the western Pacific, and the first record of N. demani Forest & Guinot, 1961, from Taiwan (Crustacea: Decapoda: Brachyura: Xanthidae), pp. 579-590 in Zootaxa 3826 (3) on page 580, DOI: 10.11646/zootaxa.3826.3.8, http://zenodo.org/record/4920416
Bittium lacteum
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Cerithiidae
Bittium
Bittium lacteum

description: Bittium lacteum (Philippi, 1836)
* Cerithium lacteum Philippi 1836: 195.
Cerithiopsis lactea Philippi — Mayer 1864: 66.
Bittium lacteum (Philippi, 1836) — Linden & Wagner 1990, fig. 3.
Bittium lacteum (Philippi, 1836) — Poppe & Goto 1991: 111, pl. 14, fig. 18.
Bittium lacteum (Philippi, 1836) — Landau et al. 2004b: 10, pl. 2, fig. 2.
Discussion. Mayer (1864: 66) recorded one specimen from the locality of Feteirinhas (= Ponta das Salinas). Bittium lacteum (Philippi, 1836) is characterised by its paucispiral protoconch and strongly tubercular spirals and three spirals on the base. We cannot confirm this record. This species does not occur nowadays in the Azores (Ávila et al. 1998, 2000; Martins et al. 2009; Cordeiro et al. 2015) nor it is present in the assemblages of the Last Interglacial deposits of Santa Maria Island (Ávila et al. 2002, 2009a, 2010, 2015a, 2018).
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (Mayer 1864). Upper Pliocene: western Mediterranean, Estepona Basin, Spain (Landau et al. 2004b). Present-day: Atlantic, British Isles, Portugal, Canary Islands and Mediterranean (Poppe & Goto 1991; Giannuzzi-Savelli et al. 1997).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 32, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Structural Insights Accelerate the Discovery of Opioid Alternatives
Creators: name: Roth B.L
name: Che T
Publisher: name: Annual Reviews Inc.
Year: 2021

description: Opioids such as morphine and oxycodone are analgesics frequently prescribed for the treatment of moderate or severe pain. Unfortunately, these medications are associated with exceptionally high abuse potentials and often cause fatal side effects, mainly through the mu -opioid receptor (MOR). Efforts to discover novel, safer, and more efficacious analgesics targeting MOR have encountered challenges. In this review, we summarize alternative strategies and targets that could be used to develop safer nonopioid analgesics. A molecular understanding of G protein-coupled receptor activation and signaling has illuminated not only the complexities of receptor pharmacology but also the potential for pathway-selective agonists and allosteric modulators as safer medications. The availability of structures of pain-related receptors, in combination with high-throughput computational tools, has accelerated the discovery of multitarget ligands with promising pharmacological profiles. Emerging clinical evidence also supports the notion that drugs targeting peripheral opioid receptors have potential as improved analgesic agents.
Chemical profile, antituberculosis, DSC, and molecular docking studies of Mentha longifolia essential oil
Creators: name: Dar, Naseer Ahmad
name: Qadir, Mahpara
name: Wani, Shahnawaz Ahmad
name: Shah, Wajaht A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: The volatile profile of Mentha longifolia was observed using GC-MS, GC-FID, FT-IR and 13CNMR. Twenty-two constituents were found to be present in this essential oil, accounting 96.04 (%) of total essential oil and oxegenated monoterpenes were major class of compounds. The key constituents of this essential oil were pieritenone oxide (45.9%), piperitone (17.5%), beta caryophyllene (10.2%), and Germacrene D (5.0%). FT-IR showed peak at 1669 and 1707 cm−1 which may be due to the presence of carbonyl groups. Among the tested compounds, Germacrene D showed highest binding affinity value of −6.8 kcal mol−1 and a pKi value of 6.01. The dsc studies revealed that boiling point of this EO is above 200 °C. Microplate Alamar Blue assay (MABA) was carried out for the assessment of antimycobacterial activity using isoniazid and nicotinic as reference compound and oil was found to be active within conc. range of 0.8–1.6 μg/mL against mycobacterium tuberculosis, hence can act as a potential candidate against antituberculosis
Schoengastiella (Jadiniella) Vercammen-Grandjean 1956
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Walchiidae
Schoengastiella

description: Subgenus Jadiniella Vercammen-Grandjean, 1956c
Schoengastiella (Jadiniella) Vercammen-Grandjean, 1956c
Jadiniella, Wen 1999a
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists
Creators: name: Zhang, H
name: Katritch, V
name: Cherezov, V
name: Guo, J
name: Huang, X.-P
name: Roth, B.L
name: Zaidi, S.A
name: Xu, L
name: Zhan, Y
name: Chen, A
name: Liu, Y
name: Zhang, D
Publisher: name: John Wiley and Sons Inc
Year: 2023

description: The peptide hormone angiotensin II regulates blood pressure mainly through the type 1 angiotensin II receptor AT1R and its downstream signaling proteins Gq and β-arrestin. AT1R blockers, clinically used as antihypertensive drugs, inhibit both signaling pathways, whereas AT1R β-arrestin-biased agonists have shown great potential for the treatment of acute heart failure. Here, we present a cryo-electron microscopy (cryo-EM) structure of the human AT1R in complex with a balanced agonist, Sar1-AngII, and Gq protein at 2.9 Å resolution. This structure, together with extensive functional assays and computational modeling, reveals the molecular mechanisms for AT1R signaling modulation and suggests that a major hydrogen bond network (MHN) inside the receptor serves as a key regulator of AT1R signal transduction from the ligand-binding pocket to both Gq and β-arrestin pathways. Specifically, we found that the MHN mutations N1113.35A and N2947.45A induce biased signaling to Gq and β-arrestin, respectively. These insights should facilitate AT1R structure-based drug discovery for the treatment of cardiovascular diseases.