cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Naltrexone a potential therapeutic candidate for COVID-19
Creators: name: Choubey, Abhinav
name: Dehury, Budheswar
name: Kumar, Sunil
name: Medhi, Bikash
name: Mondal, Prosenjit
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease (COVID-19) that has resulted in a global pandemic. At the time of writing, approximately 16.06 million cases have been reported worldwide. Like other coronaviruses, SARS-CoV-2 relies on the surface Spike glycoprotein to access the host cells, mainly through the interaction of its Receptor Binding Domain (RBD) with the host receptor Angiotensin-Converting Enzyme2 (ACE2). SARS-CoV-2 infection induces a profound downstream pro-inflammatory cytokine storm. This release of the pro-inflammatory cytokines is underpinning lung tissue damage, respiratory failure, and eventually multiple organ failure in COVID-19 patients. The phosphorylation status of ERK1/2 is positively correlated with virus load and ERK1/2 inhibition suppressed viral replication and viral infectivity. Therefore, molecular entities able to interfere with binding of the SARS-CoV-2 Spike protein to ACE2, or damping hyperinflammatory cytokines storm, blocking ERK1/2 phosphorylation have a great potential to inhibit viral entry along with viral infectivity. Herein, we report that the FDA-approved non-peptide opioid antagonist drug, naltrexone suppresses high fat/LPS induced pro-inflammatory cytokine release both from macrophage cells and Adipose Tissue Macrophage. Moreover, Low Dose Naltrexone (LDN) also showed its activity as an ERK1/2 inhibitor. Notably, virtual docking and simulation data also suggest LDN may disrupt the interaction of ACE2 with RBD. LDN may be considered as a target as the treatment and (or) adjuvant therapy for coronavirus infection. Clinical toxicity measurements may not be required for LDN since naltrexone was previously tested and is an approved drug by the FDA. Communicated by Ramaswamy H. Sarma
Detecting many-body entanglements in noninteracting ultracold atomic fermi gases
Creators: name: Levine, G. C.
name: Friedman, B. A.
name: Bantegui, M. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We explore the possibility of detecting many-body entanglement using time-of-flight (TOF) momentum correlations in ultracold atomic fermi gases. In analogy to the vacuum correlations responsible for Bekenstein-Hawking black hole entropy, a partitioned atomic gas will exhibit particle-hole correlations responsible for entanglement entropy. The signature of these momentum correlations might be detected by a sensitive TOF type experiment.
description: 5 pages, 5 figures, fixed axes labels on figs. 3 and 5, added references
An improved method for statistical studies of the internal kinematics of HII regions: the case of M 83
Creators: name: Blasco-Herrera, Javier
name: Fathi, Kambiz
name: Beckman, John E.
name: Gutiérrez, Leonel
name: Lundgren, Andreas
name: Epinat, Benoit
name: Östlin, Göran
name: Font, Joan
name: Hernandez, Olivier
name: de Denus-Bailargeon, Marie-Maude
name: Carignan, Claude
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the integrated Halpha emission line profile for 157 HII regions in the central 3.4' x 3.4' of the galaxy M 83 (NGC 5236). Using the Fabry-Perot interferometer GHaFaS, on the 4.2 m William Herschel on La Palma, we show the importance of a good characterization of the instrumental response function for the study of line profile shapes. The luminosity-velocity dispersion relation is also studied, and in the log(L)-log(sigma) plane we do not find a linear relation, but an upper envelope with equation log(L)=0.9 *log(sigma)+38.1. For the adopted distance of 4.5 Mpc, the upper envelope appears at the luminosity L=10^38.5 ergs, in full agreement with previous studies of other galaxies, reinforcing the idea of using HII regions as standard candles.
description: 13 pages, 9 figures, accepted for publication in MNRAS
Anthropocene gothic : the monstrous anthropocene of Guillermo del Toro's Crimson Peak, The Shape of Water, and Pacific Rim
Creators: name: Payne, Shannon
Publisher: name: University of British Columbia
Year: 2019

description: The anthropocene, the current geological epoch of anthropogenic climate change, presents a problem for fictional representation. Indeed, scholars have identified problems with representations of the anthropocene in both realistic fiction and climate fiction (cli-fi). The former fails to capture the surreal changes to the weather and the landscape, while the latter focuses on the future at the expense of the past and present. Cli-fi in particular has followed a mode of climate change discourse known as “catastrophizing.” This discourse evokes responses to climate change that replicate the historical power structures that caused it in the first place while putting the Global South at greater risk of suffering the consequences of climate change than the Global North. Is there a way to represent the anthropocene in fiction without replicating this discourse? In this thesis, I argue that the Gothic offers a language with which to access the historical and social complexity of the anthropocene. In order to make this argument, I perform a close reading of three Guillermo del Toro films—Crimson Peak, The Shape of Water, and Pacific Rim. These films, when taken together, form a trilogy of what I am calling “anthropocene gothic.” Del Toro’s anthropocene gothic uses monsters to represent the fraught relationship between past, present, future; blur the distinction between human and other-than-human; and break down the boundaries between self and other. Rather than focusing on large-scale disaster, these films focus on complex historical and social relationships that fueled and continue to fuel the progress of anthropogenic climate change. The anthropocene stories that these films tell are stories of violence and exploitation, as well as of kinship and transformation. These stories resist simplistic catastrophe narratives by embracing complications and the potential for a hopeful future.
title: ÐÐ°ÑÐ¸Ð°Ð½ÑÐ½Ð¾Ðµ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐ¾Ð¹Ð³ÐµÐ½Ð¿Ð»Ð°Ð½Ð¾Ð² Ð´Ð»Ñ Ð³Ð¾ÑÑÐ¸Ð½Ð¸ÑÑ Ð²ÑÑÐ¾ÑÐ¾Ð¹ Ð±Ð¾Ð»ÐµÐµ 100 Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Variant design of construction site organization for the hotel with a height of more than 100 m
Creators: name: ÐÐ»Ð¸ÑÐ»Ð¾Ð²Ð°, ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ½Ð¾Ðµ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð°Ñ Ð¿Ð»Ð¾ÑÐ°Ð´ÐºÐ°
Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð°
ÑÑÑÐ¾Ð¹Ð³ÐµÐ½Ð¿Ð»Ð°Ð½
ÑÐµÑ Ð½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸
ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð¾-Ð¼Ð¾Ð½ÑÐ°Ð¶Ð½ÑÐµ ÑÐ°Ð±Ð¾ÑÑ
ÑÐ¼ÐµÑÐ½Ð°Ñ ÑÑÐ¾Ð¸Ð¼Ð¾ÑÑÑ
Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐµ Ð´Ð¾ÑÐ¾Ð³Ð¸
Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐµ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÐµ ÑÐµÑÐ¸
variant design
construction site
construction organization
construction general plan
technical and economic indicators
construction and installation works
estimated cost
temporary roads
temporal engineering networks

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸ÑÑÑ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð°Ñ Ð¾ÑÐµÐ½ÐºÐ° ÑÐµÑÐ½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¸Ñ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ¾Ð² ÑÑÑÐ¾Ð¹Ð³ÐµÐ½Ð¿Ð»Ð°Ð½Ð¾Ð² Ñ ÑÐµÐ»ÑÑ Ð²ÑÐ±Ð¾ÑÐ° Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸Ð· Ð½Ð¸Ñ. ÐÐ²ÑÐ¾ÑÐ¾Ð¼ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ°ÑÑÑÑÑ, Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÐºÐ¾ÑÐ¾ÑÑÑ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ ÑÑÐ¾Ð¸Ð¼Ð¾ÑÑÐ¸ Ð¸Ð½Ð²ÐµÐ½ÑÐ°ÑÐ½ÑÑ Ð·Ð´Ð°Ð½Ð¸Ð¹, Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ Ð²Ð½ÑÑÑÐ¸Ð¿Ð»Ð¾ÑÐ°Ð´Ð¾ÑÐ½ÑÑ Ð´Ð¾ÑÐ¾Ð³, Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÑ ÑÐµÑÐµÐ¹ Ð¸ ÑÐ°Ð±Ð¾Ñ Ð¿Ð¾ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´ÐºÐ¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÑÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ Ð´Ð»Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ¾Ð² ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð³ÐµÐ½ÐµÑÐ°Ð»ÑÐ½ÑÑ Ð¿Ð»Ð°Ð½Ð¾Ð². ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° ÑÐ°Ð·Ð½Ð¸ÑÐ° Ð·Ð°ÑÑÐ°Ñ Ð½Ð° ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð²Ð¸Ð´Ñ ÑÐ°Ð±Ð¾Ñ Ð² Ð¿ÑÐ¾ÑÐµÐ½ÑÐ½Ð¾Ð¼ ÑÐ¾Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸.
description: In this work, a comprehensive assessment of the technical and economic indicators of several variants of construction general plans is carried out in order to select the most optimal of them. The author carried out economic calculations, as a result of which the costs of inventory buildings, temporary on-site roads, engineering networks and construction site works were determined. A comparison of these indicators was carried out for different variants of construction general plans. Difference in the cost of various types of work was calculated as a percentage.
Exploring CIP2A modulators using multiple molecular modeling approaches
Creators: name: Bhowmick, Shovonlal
name: Roy, Kunal
name: Saha, Achintya
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: Like other human oncoproteins, Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) exerts cancer promoting function through interaction with other partner proteins, such as MYC and Protein Phosphatase 2A (PP2A). CIP2A regulates several MYC-independent and/or dependent gene expression programs. Broadly, CIP2A can inhibit PP2A, and especially it has been shown to inhibit MYC-associated PP2A, precisely to increase MYC stability and function. Availability of crystal structure has broached the research focus to develop new therapeutics targeting CIP2A. In the present study, structural information of the protein has been used for identification of modulators for homo-dimer CIP2A using advanced structure-based drug design approaches. The compound library, ‘Maybridge Screening Collection’ database (∼62,000 compounds) has been virtually screened to find out potent modulators for CIP2A. Identification of hotspot region on CIP2A protein-protein interaction interface has been performed using three different tools (HotPoint, SiteMap and icmPocketFinder). Thereafter, molecular docking (Extra Precision and Induced Fit Docking), and long range molecular dynamics simulation analysis, and ADME profile analysis have been carried out for screening purposes. Calculations of MM-PBSA based binding free energy (ΔG), and Density Functional Theory for quantum chemical simulations have been carried out for the hit compounds obtained through multi-step molecular docking based virtual screening technique. The multi-chemometric studies suggested that hit modulators have formed significant numbers of molecular interactions with hotspot residues in the homo-dimer interface region, which enable to hold CIP2A binding stability. Compounds with average ΔG values (ranging –3.4 x 10−2 to −1.1 x 10−2 KJ/mol) signifying promising CIP2A modulators. Communicated by Ramaswamy H. Sarma
The HARPS search for southern extra-solar planets. XXVII. Up to seven planets orbiting HD 10180: probing the architecture of low-mass planetary systems
Creators: name: Lovis, C.
name: Ségransan, D.
name: Mayor, M.
name: Udry, S.
name: Benz, W.
name: Bertaux, J. -L.
name: Bouchy, F.
name: Correia, A. C. M.
name: Laskar, J.
name: Curto, G. Lo
name: Mordasini, C.
name: Pepe, F.
name: Queloz, D.
name: Santos, N. C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Context. Low-mass extrasolar planets are presently being discovered at an increased pace by radial velocity and transit surveys, opening a new window on planetary systems. Aims. We are conducting a high-precision radial velocity survey with the HARPS spectrograph which aims at characterizing the population of ice giants and super-Earths around nearby solar-type stars. This will lead to a better understanding of their formation and evolution, and yield a global picture of planetary systems from gas giants down to telluric planets. Methods. Progress has been possible in this field thanks in particular to the sub-m/s radial velocity precision achieved by HARPS. We present here new high-quality measurements from this instrument. Results. We report the discovery of a planetary system comprising at least five Neptune-like planets with minimum masses ranging from 12 to 25 M_Earth, orbiting the solar-type star HD 10180 at separations between 0.06 and 1.4 AU. A sixth radial velocity signal is present at a longer period, probably due to a 65-M_Earth object. Moreover, another body with a minimum mass as low as 1.4 M_Earth may be present at 0.02 AU from the star. This is the most populated exoplanetary system known to date. The planets are in a dense but still well-separated configuration, with significant secular interactions. Some of the orbital period ratios are fairly close to integer or half-integer values, but the system does not exhibit any mean-motion resonances. General relativity effects and tidal dissipation play an important role to stabilize the innermost planet and the system as a whole. Numerical integrations show long-term dynamical stability provided true masses are within a factor ~3 from minimum masses. We further note that several low-mass planetary systems exhibit a rather "packed" orbital architecture with little or no space left for additional planets. (Abridged)
description: 20 pages, 15 figures, accepted for publication in A&A
Effect of electron-beam irradiation on graphene field effect devices
Creators: name: Childres, Isaac
name: Jauregui, Luis A.
name: Foxe, Mike
name: Tian, Jifa
name: Jalilian, Romaneh
name: Jovanovic, Igor
name: Chen, Yong P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Electron beam exposure is a commonly used tool for fabricating and imaging graphene-based devices. Here we present a study of the effects of electron-beam irradiation on the electronic transport properties of graphene and the operation of graphene field-effect transistors (GFET). Exposure to a 30 keV electron-beam caused negative shifts in the charge-neutral point (CNP) of the GFET, interpreted as due to n-doping in the graphene from the interaction of the energetic electron beam with the substrate. The shift of the CNP is substantially reduced for suspended graphene devices. The electron beam is seen to also decrease the carrier mobilities and minimum conductivity, indicating defects created in the graphene. The findings are valuable for understanding the effects of radiation damage on graphene and for the development of radiation-hard graphene-based electronics.
description: 8 pages, 3 figures
Observation of an electrically tunable band gap in trilayer graphene
Creators: name: Lui, Chun Hung
name: Li, Zhiqiang
name: Mak, Kin Fai
name: Cappelluti, Emmanuele
name: Heinz, Tony F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A striking feature of bilayer graphene is the induction of a significant band gap in the electronic states by the application of a perpendicular electric field. Thicker graphene layers are also highly attractive materials. The ability to produce a band gap in these systems is of great fundamental and practical interest. Both experimental and theoretical investigations of graphene trilayers with the typical ABA layer stacking have, however, revealed the lack of any appreciable induced gap. Here we contrast this behavior with that exhibited by graphene trilayers with ABC crystallographic stacking. The symmetry of this structure is similar to that of AB stacked graphene bilayers and, as shown by infrared conductivity measurements, permits a large band gap to be formed by an applied electric field. Our results demonstrate the critical and hitherto neglected role of the crystallographic stacking sequence on the induction of a band gap in few-layer graphene.
description: 10 pages, 5 figures, including the supplementary information on the electron-hole asymmetry of ABA-stacked trilayer
Foster carers’ narrative; Looking after unaccompanied refugee children in the UK
Creators: name: Chowdhury, Halima
Publisher: name: University of East London
Year: 2022
Subjects: Unaccompanied Refugee Minors
Foster Care

description: As the number of refugees increases, the number of unaccompanied refugee children (URC) seeking asylum have continued to surge too as war, famine, and political issues are endless. Following a difficult and often traumatic journey into the United Kingdom (UK) the URC are often placed into foster homes; yet little is known about the foster placements they are placed in as the research in this area is sparse. The current literature has failed to capture the foster carer’s experience of looking after a niche group of children. This study hopes to offer a valuable insight into how we can understand their needs by adopting a narrative thematic method to hear their stories. The research was carried out with five Tower Hamlet foster carers who have had at least one URC in their placement. Each participant engaged in one semi-structured interview which was conducted online due to the Covid-19 outbreak. The interviews were recorded, transcribed by the researcher, and then analysed using narrative thematic analysis, focusing on the stories they shared about their experiences of looking after URC. The analysis found five shared narratives; ‘understanding culture’, ‘accepting help’, ‘feeling safe’, ‘our skills’, and ‘duty to help’ and one uncommon narrative ‘abusing the system’, in which foster carers described their experience.
Network analysis of a corpus of undeciphered Indus civilization inscriptions indicates syntactic organization
Creators: name: Sinha, Sitabhra
name: Ashraf, Md Izhar
name: Pan, Raj Kumar
name: Wells, Bryan Kenneth
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computation and Language (cs.CL)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Archaeological excavations in the sites of the Indus Valley civilization (2500-1900 BCE) in Pakistan and northwestern India have unearthed a large number of artifacts with inscriptions made up of hundreds of distinct signs. To date there is no generally accepted decipherment of these sign sequences and there have been suggestions that the signs could be non-linguistic. Here we apply complex network analysis techniques to a database of available Indus inscriptions, with the aim of detecting patterns indicative of syntactic organization. Our results show the presence of patterns, e.g., recursive structures in the segmentation trees of the sequences, that suggest the existence of a grammar underlying these inscriptions.
description: 17 pages (includes 4 page appendix containing Indus sign list), 14 figures
A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp)
Creators: name: Ribaudo, Giovanni
name: Ongaro, Alberto
name: Oselladore, Erika
name: Zagotto, Giuseppe
name: Memo, Maurizio
name: Gianoncelli, Alessandra
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern. The efforts of the scientific community are pointed towards the identification of promptly available therapeutic options. RNA-dependent RNA polymerase (RdRp) is a promising target for developing small molecules to contrast SARS-CoV-2 replication. Modern computational tools can boost identification and repurposing of known drugs targeting RdRp. We here report the results regarding the screening of a database containing more than 8800 molecules, including approved, experimental, nutraceutical, illicit, withdrawn and investigational compounds. The molecules were docked against the cryo-electron microscopy structure of SARS-CoV-2 RdRp, optimized by means of molecular dynamics (MD) simulations. The adopted three-stage ensemble docking study underline that compounds formerly developed as kinase inhibitors may interact with RdRp. Communicated by Ramaswamy H. Sarma
Pretrained U-BARN: Self-Supervised Spatio-Temporal Representation Learning of Satellite Image Time Series
Creators: name: Dumeur, Iris
name: Valero, Silvia
name: Inglada, Jordi
Publisher: name: Zenodo
Year: 2023
Subjects: Satellite Image Time Series
Spatio-Temporal Network
Representation Learning
Unet
BERT
pytorch
pretrained deep models

description: The pretrained Unet-BERT spatio-temporAl eNcoder (U-BARN) is available here. For further details, see section III of the pre-print article "Self-Supervised Spatio-Temporal Representation Learning Of Satellite Image Time Series" available here. This article describes the deep network architecture, as well as the pretraining method used. This model is implemented with pytorch-lightning. The implementation of the model is available in the open source directory. The median and quantile values used for a robust data scaling is also given in dataset_stats.csv. The scaling method used is described in section IV.A of the preprint.
Triviality, Renormalizability and Confinement
Creators: name: Suslov, I. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: According to recent results, the Gell-Mann - Low function β(g) of four-dimensional ϕ^4 theory is non-alternating and has a linear asymptotics at infinity. According to the Bogoliubov and Shirkov classification, it means possibility to construct the continuous theory with finite interaction at large distances. This conclusion is in visible contradiction with the lattice results indicating triviality of ϕ^4 theory. This contradiction is resolved by a special character of renormalizability in ϕ^4 theory: to obtain the continuous renormalized theory, there is no need to eliminate a lattice from the bare theory. In fact, such kind of renormalizability is not accidental and can be understood in the framework of Wilson's many-parameter renormalization group. Application of these ideas to QCD shows that Wilson's theory of confinement is not purely illustrative, but has a direct relation to a real situation. As a result, the problem of analytical proof of confinement and a mass gap can be considered as solved, at least on the physical level of rigor.
description: Latex, 15 pages
How brand hatred shapes consumer perceptions and preferences
Creators: name: Johannes, Boegershausen
Publisher: name: University of British Columbia
Year: 2019

description: Consumers frequently experience negative feelings toward brands; yet existing research has predominantly focused on positive engagements with brands. The current dissertation examines one of the most extreme negative feelings—hatred—and explores how hatred for one brand affects competing brands. Many managers seem to believe that consumers’ hatred for a close competitor would not be harmful or might even be beneficial for their brand. Nine studies using qualitative, experimental, and field data demonstrate that in contrast to managers’ beliefs, hatred for a brand leads consumers to eschew close competitors from the same subcategory. Importantly, such preference shifts do not emerge when consumers are indifferent or dissatisfied. As feeling mistreated and exploited is central to hatred, it triggers concerns about self-protection, which results in avoiding close competitors. Several moderators (i.e., greater variance in consumer ratings and the usage of safety-inducing marketing cues) supporting the self-protection based account are identified. Taken together, this dissertation emphasizes that consumer relationships with brands do not operate in a vacuum. Documenting predictable shifts in preferences for competitors as a consequence of hatred for a brand underscores the importance of extending frameworks of consumer-brand connections to incorporate negative connections and account for effects beyond a focal brand. The findings of this dissertation also suggest that hatred – at least in a consumption context – tends to prompt individuals to be primarily concerned about protecting the self rather than annihilating the hated object (i.e., brand). When consumers experience hatred, self-protection concerns appear to be pivotal in shaping their preferences for subsequent consumption unless alternative motives might interfere and produce different preferences.
title: Ð ÐµÑÐµÑÑÐ¸Ð²Ð½ÑÐµ Ð³ÐµÐ½Ñ, Ð¿ÑÐµÐ´ÑÐ°ÑÐ¿Ð¾Ð»Ð°Ð³Ð°ÑÑÐ¸Ðµ Ðº ÑÐ°ÐºÑ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ
title: Ð½Ð°ÑÑÐ½ÑÐ¹ Ð´Ð¾ÐºÐ»Ð°Ð´
titleType: Subtitle
title: Recessive genes predisposing to breast cancer
Creators: name: Ð¡Ð¾ÐºÐ¾Ð»Ð¾Ð²Ð°, Ð¢Ð°ÑÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð°Ñ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ñ
ÑÐ°Ðº Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ
Ð¿Ð¾Ð»Ð½Ð¾ÑÐºÐ·Ð¾Ð¼Ð½Ð¾Ðµ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
molecular oncology
breast cancer
whole exome sequencing

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿Ð¾Ð¸ÑÐºÑ ÑÐµÑÐµÑÑÐ¸Ð²Ð½ÑÑ Ð¼ÑÑÐ°ÑÐ¸Ð¹ Ð¿ÑÐµÐ´ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ðº ÑÐ°ÐºÑ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¿Ð¾Ð»Ð½Ð¾ÑÐºÐ·Ð¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾ÑÐ¾Ð±ÑÐ°Ð½Ð½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð² Ð±ÑÐ»Ð¾ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ ÐºÐ°Ð½Ð´Ð¸Ð´Ð°ÑÐ½ÑÑ Ð³Ð¾Ð¼Ð¾Ð·Ð¸Ð³Ð¾ÑÐ½ÑÑ (ÑÐµÑÐµÑÑÐ¸Ð²Ð½ÑÑ) Ð¼ÑÑÐ°ÑÐ¸Ð¹. ÐÐ»Ñ Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð°Ð½Ð°Ð»Ð¸Ð· in silico Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾-ÑÐ¿Ð¸Ð´ÐµÐ¼Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾ ÑÑÐµÐ¼Ðµ Â«ÑÐ»ÑÑÐ°Ð¹-ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÂ». ÐÐ»Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÑÐ¾Ð»Ð¸ Ð¼ÑÑÐ°ÑÐ¸Ð¸ Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾-Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ Ð¾Ñ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¸Ñ Ð¼ÑÑÐ°ÑÐ¸Ð¸ BRCA1 p.Gln356Arg.
description: The work is devoted to the search for recessive mutations of susceptibility to breast cancer. The whole exome sequencing of selected samples identified several candidate homozygous (biallelic) mutations. Analysis in silico and molecular epidemiological case â control study were performed. Breast tumors from carriers of BRCA1 p.Gln356Arg were analyzed for determination the role of the mutation in tumor development.
Heavy quark spin structure in Z_b resonances
Creators: name: Bondar, A. E.
name: Garmash, A.
name: Milstein, A. I.
name: Mizuk, R.
name: Voloshin, M. B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We discuss the heavy quark spin structure of the recently observed `twin' resonances $Z_b(10610)$ and $Z_b(10650)$ assuming that these are mostly of a `molecular' type, i.e. that their internal dynamics is dominated by the coupling to meson pairs $B^* \bar B - B {\bar B}^*$ and $B^* {\bar B}^*$. We find that the state of the $b \bar b$ pair within the $Z_b(10610)$ and $Z_b(10650)$ resonances is a mixture of a spin-triplet and a spin-singlet of equal amplitude and with the phase orthogonal between the two resonances. Such a structure gives rise to specific relations between observable amplitudes that are in agreement with the data obtained recently by Belle. We also briefly discuss possible properties of the isotopically singlet counterparts of the newly found resonances, and also of their $C$ ($G$) parity opposites that likely exist in the same mass range near the open $B$ flavor threshold.
description: 4 pages
CODECO D6 - Risk Assessment and Management Intermediate Report v1.0
Creators: name: C. Sofia, Rute
name: et, al.
Publisher: name: Zenodo
Year: 2024

description: CODECO Deliverable D6, "Risk Assessment and Management Intermediate Report," gives insight into the occurrence of risks and their mitigation during the first 18 months of the CODECO project. The deliverable details the risk status, and mitigation actions taken, and proposes additional mitigation measures that should be considered during the next phase of development of CODECO.
Modelling the emission from blazar jets - the case of PKS 2155-304
Creators: name: Weidinger, Matthias
name: Spanier, Felix
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A time-dependent Synchrotron Self Compton model (SSC) which is able to motivate the used electron spectra of many SSC models as a balance of acceleration and radiative losses is introduced. Using stochastic acceleration as well as Fermi-I processes even electron spectra with a rising part can be explained, which are mandatory to fit the lowstate spectral energy distribution (SED) of PKS 2155-304 as constrained from Fermi LAT observations. Due to the time resolution the outburst of PKS 2155-304 observed by H.E.S.S. in 2006 can be modelled selfconsistently as fluctuations along the jet axis without introducing new sets of parameters. The model makes the time evolution of the SED also accessible. Hence giving new insights into the flaring behavior of blazars.
description: 6 pages, 2 figures; to appear in the proceedings of the conference: "High Energy Phenomena in Relativistic Outflows (HEPRO) II", held in Buenos Aires, Argentina, October 26-30 2009 (IJMPD)
Well-posedness of quasilinear parabolic equations in time-weighted spaces
Creators: name: Matioc, Bogdan-Vasile
name: Walker, Christoph
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: quasilinear parabolic problem, semiflow, well-posedness, time-weighted-spaces, chemotaxis equations
subject: 510 Mathematik
subject: Primary: 35B40
subject: Secondary: 35K58 35K59 35Q92

description: Well-posedness in time-weighted spaces of certain quasilinear (and semilinear) parabolic evolution equations u′=A(u)u+f(u) is established. The focus lies on the case of strict inclusions dom(f)⊊dom(A) of the domains of the nonlinearities u↦f(u) and u↦A(u). Based on regularizing effects of parabolic equations it is shown that a semiflow is generated in intermediate spaces. In applications this allows one to derive global existence from weaker a priori estimates. The result is illustrated by examples of chemotaxis systems.
Drug repurposing for schistosomiasis: molecular docking and dynamics investigations
Creators: name: Ezebuo, Fortunatus C.
name: Uzochukwu, Ikemefuna C.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Schistosomiasis is a neglected disease of considerable health importance in tropical and subtropical regions. Its treatment relies on the use of praziquantel or oxamniquine but there are reported cases of treatment failures due to resistance or tolerance. Again, derivatives of praziquantel and oxamniquine have not shown significant activities than their parent compounds. The study predicted approved drugs with possible antischistosomal activities. Four schistosomal drug targets were obtained from Protein Data Bank and six hundred and twelve (612) approved drugs including their isomers were selected based on their Molinspiration® bioscore similarities with reference compounds (praziquantel, oxamniquine, [(2S,3S,4S,5S,6S)-3,4,5-triacetyloxy-6-sulfanyloxan-2-yl] methyl acetate, [propylamino-3-hydroxy-buta-1,4-dionyl]-isoleucylproline). The selected drugs and drug targets were obtained and prepared for molecular docking simulations. The molecular docking simulations were performed using AutoDockvina®-1.1.2 after validation of docking protocols while molecular dynamics simulations were performed with GROMACS-4.5.5. The binding energies were calculated using MMPBSA (Molecular Mechanics Poisson-Boltzmann Surface Area). Tolmetin was predicted as potential antischistosomal drug with binding energies of −231.064 ± 18.550 and −338.636 ± 36.900 KJ/mol for sulfotransferase and thioredoxin glutathione reductase (TGR) respectively. Also diflunisal was predicted as potential antischistosomal drug with binding energies of −168.641 ± 20.370 and −290.117 ± 43.800 KJ/mol for sulfotransferase and TGR respectively. Non-covalent interactions and conformational changes were responsible for molecular recognitions and specificities and average bond measurement showed that carboxylic functional groups in diflunisal and tolmetin may interact covalently with -SH group of Cys159 in TGR. Confirmation of covalent interactions and in vitro validations are recommended. Communicated by Ramaswamy H. Sarma
Red Supergiant Stars in the Large Magellanic Cloud: I. The Period-Luminosity Relation
Creators: name: Yang, Ming
name: Jiang, B. W.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: From previous samples of Red Supergiants (RSGs) by various groups, 191 objects are assembled to compose a large sample of RSG candidates in LMC. For 189 of them, the identity as a RSG is verified by their brightness and color indexes in several near- and mid-infrared bands related to the 2MASS JHKs bands and the Spitzer/IRAC and Spitzer/MIPS bands. From the visual time-series photometric observations by the ASAS and MACHO projects which cover nearly 8-10 years, the period and amplitude of light variation are analyzed carefully using both the PDM and Period04 methods. According to the properties of light variation, these objects are classified into five categories: (1) 20 objects are saturated in photometry or located in crowded stellar field with poor photometric results, (2) 35 objects with too complex variation to have any certain period, (3) 23 objects with irregular variation, (4) 16 objects with semi-regular variation, and (5) 95 objects with Long Secondary Period (LSP) among which 31 have distinguishable short period, and 51 have a long period shorter than 3000 days that can be determined with reasonable accuracy. For the semi-regular variables and the LSP variables with distinguishable short period, the period-luminosity relation is analyzed in the visual, near-infrared and mid-infrared bands. It is found that the P-L relation is tight in the infrared bands such as the 2MASS JHKs bands and the Spitzer/IRAC bands, in particular in the Spitzer/IRAC [3.6] and [4.5] bands; meanwhile, the P-L relation is relatively sparse in the V band which may be caused by the inhomogeneous interstellar extinction. The results are compared with others' P-L relationships for RSGs and the P-L sequences of red giants in LMC.
description: 41 pages, 14 figures, 4 tables, accepted by ApJ
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð°Ð¹Ð´ÐµÐ½ÑÐ¸ÐºÐ¸ Ð´Ð»Ñ Ð¼ÑÐ·ÐµÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of corporate identity for the museum
Creators: name: Ð¡Ð¼ÐµÐ»ÐºÐ¾Ð²Ð°, ÐÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð´Ð¸Ð·Ð°Ð¹Ð½
ÑÐ¸ÑÐ¼ÐµÐ½Ð½ÑÐ¹ ÑÑÐ¸Ð»Ñ
Ð³ÐµÐ¾Ð»Ð¾Ð³Ð¸Ñ
Ð¼ÑÐ·ÐµÐ¹
ÑÐµÐºÐ»Ð°Ð¼Ð½ÑÐ¹ Ð¿Ð»Ð°ÐºÐ°Ñ
ÑÑÐ²ÐµÐ½Ð¸ÑÐ½Ð°Ñ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ
ÐºÐ¾ÑÐ¿Ð¾ÑÐ°ÑÐ¸Ð²Ð½ÑÐµ Ð¿Ð¾Ð´Ð°ÑÐºÐ¸
Ð²ÐµÐ±-ÑÐ°Ð¹Ñ
design
firm style
geology
museum
advertising poster
souvenirs
corporate gifts
website

description: Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ â ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ¾Ð² ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ Ð¸ Ð´Ð¸Ð·Ð°Ð¹Ð½Ð° ÑÐ°Ð¹ÑÐ° Ð´Ð»Ñ Ð¼ÑÐ·ÐµÑ ÐÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ°. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» ÑÐ¾Ð·Ð´Ð°Ð½ Ð»Ð¾Ð³Ð¾ÑÐ¸Ð¿, ÑÐ»ÐµÐ¼ÐµÐ½ÑÑ ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ, ÑÐµÐºÐ»Ð°Ð¼Ð½Ð¾-Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¿Ð»Ð°ÐºÐ°ÑÑ, ÑÑÐ²ÐµÐ½Ð¸ÑÐ½Ð°Ñ Ð¸ ÐºÐ¾ÑÐ¿Ð¾ÑÐ°ÑÐ¸Ð²Ð½Ð°Ñ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ, ÑÐµÐ´Ð¸Ð·Ð°Ð¹Ð½ ÑÐ°Ð¹ÑÐ° Ð¸ Ð¾ÑÐ¾ÑÐ¼Ð»ÐµÐ½Ð¸Ðµ ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÑÐµÑÐµÐ¹. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð½Ð°Ð´ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð¼ ÑÐ°Ð·Ð¾Ð±ÑÐ°Ð½Ñ Ð¸ Ð¿ÑÐ¾ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð°ÑÐ¿ÐµÐºÑÑ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ, Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð° Ð°ÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ Ð¸ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÑ Ð²Ñ-Ð±ÑÐ°Ð½Ð½Ð¾Ð¹ ÑÐµÐ¼Ð°ÑÐ¸ÐºÐ¸, Ð¸Ð·ÑÑÐµÐ½Ð° Ð¿ÑÐµÐ´Ð¼ÐµÑÐ½Ð°Ñ Ð¾Ð±Ð»Ð°ÑÑÑ, ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ Ð¸ Ð½Ð°Ð¹Ð´ÐµÐ½Ð¾ ÑÑÐ¸Ð»Ð¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ. ÐÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½ÑÐ¹ Ð¿Ð¾Ð´ÑÐ¾Ð´ Ðº ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð²Ð¸Ð·ÑÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¿ÑÐ¸Ð·Ð²Ð°Ð½ Ð¿Ð¾Ð¿ÑÐ»ÑÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ ÐºÐ°Ðº ÑÐ°Ð¼ Ð½Ð°ÑÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¸Ð¹ ÐÐ¾ÑÐ½ÑÐ¹ Ð¼ÑÐ·ÐµÐ¹, ÑÐ°Ðº Ð¸ Ð½Ð°ÑÐºÑ, Ð² ÑÐ°ÑÑÐ½Ð¾ÑÑÐ¸.
description: The purpose of the work is to develop a corporate identity and website design elements for the Museum of the Mining University. As a result of the work, a logo, elements of corporate identity, advertising and information posters, souvenir and corporate products, website redesign, and design of social networks were created. In the course of work on the project, aspects of creating a corporate identity were sorted out and worked out, the relevance and significance of the selected topic were analyzed, the subject area was studied, a concept was developed and a stylistic solution was found. An integrated approach to the development of a visual system is intended to popularize both the Research Mining Museum itself and science.
Interaction of memantine with calf thymus DNA: an in-vitro and in-silico approach and cytotoxic effect on the cancerous cell lines
Creators: name: Ameen, Faisal
name: Siddiqui, Sharmin
name: Kausar, Tasneem
name: Nayeem, Shahid M.
name: Sarwar, Tarique
name: Rizvi, Mohammad Moshahid Alam
name: Rehman, Sayeed ur
name: Tabish, Mohammad
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 60506 Virology

description: Memantine belongs to the class of cognition enhancers that functions as NMDA receptor antagonist, used to treat Alzheimer's disease. The interaction of memantine with DNA was not investigated. In the present study, the interaction of memantine with ct-DNA, as well as its cytotoxicity on cancer cells, was evaluated. UV-visible spectroscopy, steady-state fluorescence spectroscopic studies revealed the interaction between memantine and ct-DNA. The quenching studies, chemical denaturation, (CD), and DNA melting studies showed the groove binding mode of memantine with ct-DNA. The thermodynamic parameters revealed that the interaction between memantine and ct-DNA is enthalpically driven, and the stabilizing forces involved were hydrogen bonding and van der Waals interaction. The groove-binding was also observed by molecular docking studies, which corroborated the findings of spectroscopic investigations. Density function theory calculations confirmed the existence of electron donor and recipient groups. The stability of memantine and DNA interaction, as well as the critical residues involved in the interaction, was identified by molecular dynamics simulations. Memantine showed cytotoxicity towards the cancer cells as compared to normal cells, as observed by MTT assay. Inverted compound microscopy analysis of memantine treated cancer cell lines further confirmed the results obtained by MTT assay. Communicated by Ramaswamy H. Sarma
Astrointerferometry with discrete optics
Creators: name: Minardi, Stefano
name: Pertsch, Thomas
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We propose an innovative scheme exploiting discrete diffraction in a two dimensional array of coupled waveguides to determine the phase and amplitude of the mutual correlation function between any pair of three telescopes of an astrointerferometer.
description: 9 pages, 3 figures, Submitted to Optics Letters
Desert-wide Cultural Resource protection in the Mojave Desert - Report (Legacy 05-257)
Creators: name: A. Michael Pappalardo
name: Goodwin, Matt
Publisher: name: DoD Legacy Resource Management Program
Year: 2006
Subjects: subject: Mojave Desert
valueUri: https://core.tdar.org/browse/geographic-keyword/7717/mojave-desert
subject: United States
valueUri: https://core.tdar.org/browse/geographic-keyword/10460/united-states
subject: Department of Defense
valueUri: https://core.tdar.org/browse/other-keyword/123614/department-of-defense
subject: Site Protection Plan
valueUri: https://core.tdar.org/browse/other-keyword/90449/site-protection-plan
subject: Mojave Desert
valueUri: https://core.tdar.org/browse/other-keyword/124152/mojave-desert
subject: military installations
valueUri: https://core.tdar.org/browse/other-keyword/159734/military-installations
subject: Site Protection
valueUri: https://core.tdar.org/browse/other-keyword/11145/site-protection
subject: Federal Law and Policy
valueUri: https://core.tdar.org/browse/other-keyword/165947/federal-law-and-policy
subject: Cultural Resources Management
valueUri: https://core.tdar.org/browse/other-keyword/7068/cultural-resources-management
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This report describes the authors efforts to 1) determine the nature and severity of site protection problems within the Mojave Desert, 2) examine successful site protection programs within the United States, 3) examine the data collected in the first two goals, and 4) summarize the finding and make recommendations regarding the feasibility of developing a regional site protection plan for the Mojave Desert.
Metrics with Galilean Conformal Isometry
Creators: name: Bagchi, Arjun
name: Kundu, Arnab
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Galilean Conformal Algebra (GCA) arises in taking the non-relativistic limit of the symmetries of a relativistic Conformal Field Theory in any dimensions. It is known to be infinite-dimensional in all spacetime dimensions. In particular, the 2d GCA emerges out of a scaling limit of linear combinations of two copies of the Virasoro algebra. In this paper, we find metrics in dimensions greater than two which realize the finite 2d GCA (the global part of the infinite algebra) as their isometry by systematically looking at a construction in terms of cosets of this finite algebra. We list all possible sub-algebras consistent with some physical considerations motivated by earlier work in this direction and construct all possible higher dimensional non-degenerate metrics. We briefly study the properties of the metrics obtained. In the standard one higher dimensional "holographic" setting, we find that the only non-degenerate metric is Minkowskian. In four and five dimensions, we find families of non-trivial metrics with a rather exotic signature. A curious feature of these metrics is that all but one of them are Ricci-scalar flat.
description: 20 pages
title: Locating Scotland in the 20th Kilbrandon Lecture : children of the beloved country – lives and legacies from Kilbrandon to Mandela
Creators: name: Shields, Sophie
Publisher: name: Strathprints - University of Strathclyde
Year: 2023

description: This paper is a response to the 20th Kilbrandon Lecture - 'Children of the beloved country – lives and legacies from Kilbrandon to Mandela' – delivered by Professor Ann Skelton. This response serves to locate Professor Skelton's experiences in South Africa and at the United Nations in Scotland's own unique national context, as a country embarking on an ambitious programme of change in its human rights journey. This response considers the incorporation of the United Nations Convention on the Rights of the Child as a landmark moment in Scotland, overcoming and utilising a complex policy landscape, and as a commitment and responsibility despite compounding national and global crises threatening the rights and wellbeing of children in Scotland.
Comunicación social 24/7
Creators: name: Suing, Abel
Publisher: name: Zenodo
Year: 2020
Subjects: Comunicación
Social
Covid-19
Ecuador
economía
elecciones
media

description: Publicación en la sección de opinión del diario digital hora 32 https://hora32.com.ec/ que se edita en Loja (Ecuador)