cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Microscopy of a scalable superatom
Creators: name: Zeiher, Johannes
name: Schauß, Peter
name: Hild, Sebastian
name: Macrì, Tommaso
name: Bloch, Immanuel
name: Gross, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Strong interactions can amplify quantum effects such that they become important on macroscopic scales. Controlling these coherently on a single particle level is essential for the tailored preparation of strongly correlated quantum systems and opens up new prospects for quantum technologies. Rydberg atoms offer such strong interactions which lead to extreme nonlinearities in laser coupled atomic ensembles. As a result, multiple excitation of a Micrometer sized cloud can be blocked while the light-matter coupling becomes collectively enhanced. The resulting two-level system, often called "superatom", is a valuable resource for quantum information, providing a collective Qubit. Here we report on the preparation of two orders of magnitude scalable superatoms utilizing the large interaction strength provided by Rydberg atoms combined with precise control of an ensemble of ultracold atoms in an optical lattice. The latter is achieved with sub shot noise precision by local manipulation of a two-dimensional Mott insulator. We microscopically confirm the superatom picture by in-situ detection of the Rydberg excitations and observe the characteristic square root scaling of the optical coupling with the number of atoms. Furthermore, we verify the presence of entanglement in the prepared states and demonstrate the coherent manipulation of the superatom. Finally, we investigate the breakdown of the superatom picture when two Rydberg excitations are present in the system, which leads to dephasing and a loss of coherence.
description: 7 pages, 5 figures
(3500) Anne Elizabeth Griffith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title:  Modernità e attualità della pratica diaristica di Jonas Mekas
Creators: name: Trivelli, Anita
Publisher: name: Roma TrE-Press
Year: 2016

description: La pratica creativa e intellettuale di Jonas Mekas è permeata da una profonda vena diaristica. Poeta, cineasta, critico e curatore cinematografico, il leader riconosciuto del New American Cinema propone un cinema diaristico molto personale, chiaro esempio di quella esperienzialità che è una delle caratteristiche più pregnanti delle pratiche stilistiche del cinema «moderno». Il cinema di Mekas è una sorta di action cinema imparentato all’action painting d’oltreoceano, innestato in un’opera di scrittura della memoria di celluloide, fatta di riprese fibrillanti, di lampi di vita in continuo divenire. Un divenire che approda a una vera e propria dimensione mitologica, dove la relazione con la vitalità della natura si coniuga col movimento profondo della psiche. Ripercorrendo le principali tappe del cinema diaristico di Jonas Mekas, l’intervento mirerà a sciogliere l’apparente paradosso di un cinema tutto immerso nel quotidiano, e al tempo stesso estatico, immerso in una unità cosmica apparentemente indistinta, fatta di risonanze emozionali di straordinaria intensità.
description: Modernità nelle Americhe
title: Multidisciplinary Reference Solutions for Performance-Optimized Aircraft Wings with Tailored Aerodynamic Load Distributions
Creators: name: Taylor, Jeffrey D.
Publisher: name: Utah State University
Year: 2022

description: Morphing wings, or wings that can change shape during flight, have the potential to substantially reduce the amount of fuel consumed by an aircraft over the course of its flight. However, the extent to which these wings can reduce fuel consumption depends on the design of the wing, including its aerodynamic efficiency and its structural layout, and how the aircraft flies, including its flight altitude and speed. Correctly predicting how these design and operational characteristics interact is critical to predicting how wing morphing may affect aircraft fuel consumption. Many computer prediction tools exist that include the effects of these interactions, but extracting the information needed to understand how the interactions work from most of these tools is very difficult. In this dissertation, some simplified models are presented that more directly reveal key information about the interplay between aerodynamics, structures, control, and the flight trajectory in the design of morphing wings. This information is used to characterize the impacts of wing morphing on aircraft efficiency.
Spin and Wind Directions I: Identifying Entanglement in Nature and Cognition
Creators: name: Aerts, Diederik
name: Arguëlles, Jonito Aerts
name: Beltran, Lester
name: Geriente, Suzette
name: de Bianchi, Massimiliano Sassoli
name: Sozzo, Sandro
name: Veloz, Tomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Quantum Physics (quant-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We present a cognitive psychology experiment where participants were asked to select pairs of spatial directions that they considered to be the best example of 'Two Different Wind Directions'. Data are shown to violate the CHSH version of Bell's inequality with the same magnitude as in typical Bell-test experiments with entangled spins. Wind directions thus appear to be conceptual entities connected through meaning, in human cognition, in a similar way as spins appear to be entangled in experiments conducted in physics laboratories. This is the first part of a two-part article. In the second part we present a symmetrized version of the same experiment for which we provide a quantum modeling of the collected data in Hilbert space.
description: The content of the previous article's versions has now been expanded and reorganized in a two-part article of which this is the first half, the second half being entitled 'Spin and Wind Directions II: A Bell State Quantum Model' and to be found at arXiv:1706.01188
Rho factor mediates flagellum and toxin phase variation and impacts virulence in Clostridioides difficile
Creators: name: Tamayo, R.
name: Torres Rivera, D.
name: Trzilova, D.
name: Anjuwon-Foster, B.R.
Publisher: name: Public Library of Science
Year: 2020

description: The intestinal pathogen Clostridioides difficile exhibits heterogeneity in motility and toxin production. This phenotypic heterogeneity is achieved through phase variation by site-specific recombination via the DNA recombinase RecV, which reversibly inverts the “flagellar switch” upstream of the flgB operon. A recV mutation prevents flagellar switch inversion and results in phenotypically locked strains. The orientation of the flagellar switch influences expression of the flgB operon post-transcription initiation, but the specific molecular mechanism is unknown. Here, we report the isolation and characterization of spontaneous suppressor mutants in the non-motile, non-toxigenic recV flg OFF background that regained motility and toxin production. The restored phenotypes corresponded with increased expression of flagellum and toxin genes. The motile suppressor mutants contained single-nucleotide polymorphisms (SNPs) in rho, which encodes the bacterial transcription terminator Rho factor. Analyses using transcriptional reporters indicate that Rho contributes to heterogeneity in flagellar gene expression by preferentially terminating transcription of flg OFF mRNA within the 5’ leader sequence. Additionally, Rho is important for initial colonization of the intestine in a mouse model of infection, which may in part be due to the sporulation and growth defects observed in the rho mutants. Together these data implicate Rho factor as a regulator of gene expression affecting phase variation of important virulence factors of C. difficile.
Additional file 1 of Spatiotemporal parameters for energy efficient kilohertz-frequency nerve block with low onset response
Creators: name: Peña, Edgar
name: Pelot, Nicole A.
name: Grill, Warren M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Additional tables and figures.
title: Spatiotemporal Data Augmentation of MODIS-LANDSAT Water Bodies Using Generative Adversarial Networks
Creators: name: Neema, Ashit
Publisher: name: Utah State University
Year: 2022

description: The monitoring of the shape and area of a water body is an essential component for many Earth science and Hydrological applications. For this purpose, these applications require remote sensing data which provides accurate analysis of the water bodies. In this thesis the same is being attempted, first, a model is created that can map the information from one kind of satellite that captures the data from a distance of 500m to another data that is captured by a different satellite at a distance of 30m. To achieve this, we first collected the data from both of the satellites and translated the data from one satellite to another using our proposed Hydro-GAN model. This translation gives us the accurate shape, boundary, and area of the water body. We evaluated the method by using several different similarity metrics for the area and the shape of the water body. The second part of this thesis involves augmenting the data that we obtained from the Hydro-GAN model with the original data and using this enriched data to predict the area of a water body in the future. We used the case study of Great Salt lake for this purpose.
The results indicated that our proposed model was creating accurate area and shape of the water bodies. When we used our proposed model to generate data at a resolution of 30m it gave us better areal and shape accuracy. If we get more data at this resolution, we can use that data to better predict coastal lines, boundaries, as well as erosion monitoring.
Enhancing bacterial survival through phenotypic heterogeneity
Creators: name: Ruiz, L.M.R.
name: Tamayo, R.
name: Williams, C.L.
Publisher: name: Public Library of Science
Year: 2020

description: What are the benefits of phenotypic heterogeneity? The ability of bacterial populations to develop phenotypically heterogeneous subpopulations has been recognized for decades. A recent study found that genetic hallmarks of phenotypic heterogeneity are ubiquitous among bacterial species of the intestinal microbiota, underscoring that this is a broadly employed, underappreciated survival strategy for both pathogenic and commensal bacterial species. Phenotypic heterogeneity—functional diversity among genetically identical cells—can permit division of labor and cooperative behaviors or serve as a bet-hedging strategy to help ensure the survival of the population as a whole. Division of labor occurs when biological processes are separated among subpopulations, conferring an overall fitness advantage to the population. For example, the opportunistic pathogen Pseudomonas aeruginosa forms multiple unique cell types that perform specialized roles in the formation of biofilm. Some cells contribute to biofilm extracellular matrix production and initiate biofilm development, while others exhibit surface motility and allow biofilm expansion. In the bet-hedging strategy, incorporating phenotypic variants into a population increases the likelihood that some members will survive a stress. In settings where environmental changes are rapid and stark, phenotypic heterogeneity helps ensure the survival of the population at the expense of individuals not well suited to the current environment, which are selected against and lost. This strategy is advantageous over traditional sense-and-respond mechanisms, which require an adaptation time that may be insufficient in the face of sudden or severe environmental changes. Mechanisms of phenotypic heterogeneity may be particularly important in the context of disease, as these mechanisms are more common in host-associated bacteria than in aquatic or terrestrial species.
A Semi-automatic Search for Giant Radio Galaxy Candidates and their Radio-Optical Follow-up
Creators: name: Santiago-Bautista, I. del C.
name: Rodriguez-Rico, C. A.
name: Andernach, H.
name: Coziol, R.
name: Torres-Papaqui, J. P.
name: Andrade, E. F. Jimenez
name: Plauchu-Frayn, I.
name: Momjian, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present results of a search for giant radio galaxies (GRGs) with a projected largest linear size in excess of 1 Mpc. We designed a computational algorithm to identify contiguous emission regions, large and elongated enough to serve as GRG candidates, and applied it to the entire 1.4-GHz NRAO VLA Sky survey (NVSS). In a subsequent visual inspection of 1000 such regions we discovered 15 new GRGs, as well as many other candidate GRGs, some of them previously reported, for which no redshift was known. Our follow-up spectroscopy of 25 of the brighter hosts using two 2.1-m telescopes in Mexico, and four fainter hosts with the 10.4-m Gran Telescopio Canarias (GTC), yielded another 24 GRGs. We also obtained higher-resolution radio images with the Karl G. Jansky Very Large Array for GRG candidates with inconclusive radio structures in NVSS.
description: 4 pages, 1 figure, to appear in the proceedings of The Universe of Digital Sky Surveys, Naples, Italy, Nov 25-28, 2014; Astrophysics and Space Science, eds. N.R. Napolitano et al
Read online: The Priory of the Orange Tree by Samantha Shannon
Creators: name: Rybicki
Publisher: name: Zenodo
Year: 2024

description: The Priory of the Orange Tree by Samantha Shannon

 

 

Download Book ➡ Link

Read Book Online ➡ Link

 

 

The Priory of the Orange Tree

Samantha Shannon

Page: 848

Format: pdf, ePub, mobi, fb2

ISBN: 9781635570298

Publisher: Bloomsbury USA

 

Download ebook from google books free The Priory of the Orange Tree iBook FB2

Torrent PDF The Priory of the Orange Tree by Samantha Shannon EPUB Download and online reading may begin. Formats Available : PDF, ePub, Mobi, doc Total Reads - Total Downloads - File Size The Priory of the Orange Tree EPUB PDF Download Read Samantha Shannon. Best book torrent sites Download it here and read it on your Kindle device. Check this ebook now Pages Published Publisher. Publication Date of this book EPUB The Priory of the Orange Tree By Samantha Shannon PDF Download. Tweets The Priory of the Orange Tree EPUB PDF Download Read Samantha Shannon Paperback Fiction Secure PDF EPUB Readers. Download at full speed with unlimited bandwidth PDF The Priory of the Orange Tree by Samantha Shannon EPUB Download just one click. Today I'm sharing to youThe Priory of the Orange Tree EPUB PDF Download Read Samantha Shannonand this ebook is ready for read and download. Kindle Editions Novel Series.

PDF The Priory of the Orange Tree by Samantha Shannon EPUB Download Share link here and get free ebooks to read online. Download it once and read it on your PC or mobile device PDF The Priory of the Orange Tree by Samantha Shannon EPUB Download. Reviews in epub, pdf and mobi formats. Facebook share full length digital edition EPUB The Priory of the Orange Tree By Samantha Shannon PDF Download. Available in epub, pdf and mobi format PDF The Priory of the Orange Tree by Samantha Shannon EPUB Download, reviewed by readers. Best book torrent sites Download it here and read it on your Kindle device. Read without downloading PDF The Priory of the Orange Tree by Samantha Shannon EPUB Download Book Format PDF EPUB Kindle. Today I'm sharing to youThe Priory of the Orange Tree EPUB PDF Download Read Samantha Shannonand this ebook is ready for read and download.
(3501) Annie Elizabeth Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Made for You: A Novel by Jenna Satterthwaite on Iphone New Format
Creators: name: Burns
Publisher: name: Zenodo
Year: 2024

description: Made for You: A Novel by Jenna Satterthwaite

 

 

Download Book ➡ Link

Read Book Online ➡ Link

 

 

Made for You: A Novel

Jenna Satterthwaite

Page: 400

Format: pdf, ePub, mobi, fb2

ISBN: 9780778310426

Publisher: MIRA Books

 

Mobile bookshelf download Made for You: A Novel 9780778310426

Made for You by Jenna Satterthwaite Julia a synth finds herself in some hot water when she becomes the prime suspect in her husbands murder. Told in dual timelines you follow Julia from when she  Book Review: Made You Up Alex fights a daily battle to figure out the difference between reality and delusion. Armed with a take-no-prisoners attitude, her camera, a  Create Custom Photo Books & Albums Online Create Photo Books, Your Way. Whether you want to do it yourself or let us design it for you, we make it easy to create a book you'll love. How Making Time for Books Made Me Feel Less Busy I might have an unpublished novel in a drawer somewhere. I love books. And yet, I wasn't reading them. In fact, I couldn't read them. I tried,  Seven books that will make you put down your phone Caliban, a novella that's less than 150 pages, with a fascinating plot and quick pacing. Written in 1982 but reissued in 2017, Mrs. Caliban  Made for You by Melissa Marr, Paperback Eva Tilling wakes up in the hospital to discover she possesses a strange new skill—the ability to foresee people's deaths when they touch her. Would You Rather? Made You Think! Edition - by Lindsey Enjoy hours of laughter with hilarious questions for kids that get harder as the book goes on. · 9-12 Years · 7.9" x 5.0" Paperback · 128 Pages · Juvenile  Review: 'It Starts With Us' takes readers through the pain of make it its own individual story. While not a standalone, the you received when you were twelve. Some love arrives all at once, like
[Kindle] LENGUA Y LITERATURA 2º ESO CONSTRUYENDO MUNDOS ED 2023 descargar gratis
Creators: name: Bieber
Publisher: name: Zenodo
Year: 2024

description: LENGUA Y LITERATURA 2º ESO CONSTRUYENDO MUNDOS ED 2023 de

Descargar eBook gratis ➡ Link

Ficha técnica

LENGUA Y LITERATURA 2º ESO CONSTRUYENDO MUNDOS ED 2023

 

Número de páginas: 320

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788414407455

Editorial: SANTILLANA

Año de edición: 2023

 

 

 

 

 

Descargar libros electronicos torrent LENGUA Y LITERATURA 2º ESO CONSTRUYENDO MUNDOS ED 2023 de 9788414407455 PDB PDF (Spanish Edition)

 

Overview
An in vitro intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface
Creators: name: Allbritton, N.L.
name: Furtado, K.L.
name: Tamayo, R.
name: Wang, Y.
name: Attayek, P.J.
name: Kim, R.
name: Sims, C.E.
Publisher: name: Institute of Physics Publishing
Year: 2020

description: An oxygen gradient formed along the length of colonic crypts supports stem-cell proliferation at the normoxic crypt base while supporting obligate anaerobe growth in the anoxic colonic lumen. Primary human colonic epithelial cells derived from human gastrointestinal stem cells were cultured within a device possessing materials of tailored oxygen permeability to produce an oxygen-depleted luminal (0.8% ± 0.1% O2) and oxygen-rich basal (11.1% ± 0.5% O2) compartment. This oxygen difference created a stable oxygen gradient across the colonic epithelial cells which remained viable and properly polarized. Facultative and obligate anaerobes Lactobacillus rhamnosus, Bifidobacterium adolescentis, and Clostridium difficile grew readily within the luminal compartment. When formed along the length of an in vitro crypt, the oxygen gradient facilitated cell compartmentalization within the crypt by enhancing confinement of the proliferative cells to the crypt base. This platform provides a simple system to create a physiological oxygen gradient across an intestinal mimic while simultaneously supporting anaerobe co-culture.
Climate-oriented land use management
Creators: name: Budziak, Olha
name: Budziak, Vasyl
name: Drebot, Oksana
name: Budziak, Olha
name: Budziak, Vasyl
name: Drebot, Oksana
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: Land Economics/Use
subject: land
subject: land use
subject: land use management
subject: climate change

description: Purpose. The purpose of the article is to investigate the interaction of climate change with land use to properly understand the consequences and make management decisions, taking into account all the risks and opportunities to ensure non-extensive use and long-term conservation of land resources for future generations. Methodology / approach. The methodological approach involves studying the practice of land use management by analyzing integrated indicators: vulnerability of land use to climate change (responding for climate change prevention) and assessing the impact of climate change on land use (adaptation to climate change) the basis for the calculation of which were quantitative and qualitative indicators for the period 2000–2020. Results. It is established that the existing land management system in Ukraine in accordance with the policy of international organizations and the Sustainable Development Agenda until 2030 requires consideration of new technologies and practices in combating climate change and its consequences based on national conditions and priorities. Studies of the effectiveness of management measures in the field of land use showed that in the period 2000–2009, responding measures for climate change prevention were mostly targeted, and in 2010–2020 acquired signs of systemicity, while for the entire study period the effectiveness of adaptation measures underwent minor changes. At the same time, having positive dynamics, but different trends in the period from 2012 to 2014, measures to respond and adapt to climate challenges equalized in effectiveness. It is found that after 2014, more efforts, financial resources and means have begun to be spent on combating the consequences than on measures to adapt to climate change. This means that the current land management system needs immediate transformation. After all, it is impossible to allow any extreme phenomena to jeopardize the food security of the state. The effectiveness of management activities should be not only in a timely response, but first of all in trying to be proactive reducing vulnerability and increasing the resilience of land use to climate change. Originality / scientific novelty. This is the first comparative analysis of the effectiveness of land management measures regarding the interaction of climate change with land use according to indicators in dynamics. The need to increase the adaptive capacity to reduce potential losses in land use in the future is substantiated. Practical value / implications. The results of the study can serve as a basis for modernization of existing land use projects and improvement of ways to manage them on the basis of low-carbon development to ensure food security of the population of Ukraine in the context of climate change.
title: DAISIE - European Union extended working life policies: on pension systems, public finances and biopolitical disciplining
Creators: name: Krekula, Clary
Publisher: name: Swiss Centre of Expertise in Life Course Research
Year: 2020

description: This report explores the rhetoric surrounding extended working life (EWL) in three central documents from the European Commission. It sheds light on the underlying problems that raising the retirement age is assumed to solve, the rhetoric and arguments used in favour of EWL policies, as well as the assumptions about the capacity of women and men to continue working in older age. The analysis is based on an understanding of policies as active constructors of problems. Accordingly, the problems that the policy addresses are not seen as objective entities; rather, they are understood as discursively formed by the policies. The results show both similarities and differences between the documents analysed. Behind explicit reference to the need to increase retirement age in order to secure the pension systems, there are assumptions implying that it would also strengthen public finances and that this could take place by ‘disciplining’ older women and men into working longer and increasing their private savings. In arguments on economic vulnerability among older people, extended working life is also portrayed as necessary for older people to receive adequate pensions. Further, the analysis identifies contradictory perspectives on pension gender gaps. On the one hand, this gap is described as a result of the difference in retirement age between women and men, and on the other, as a consequence of events that took place during their prior working life. Finally, the analysis identifies dichotomous divisions between working life as productive time and retirement as unproductive time. This rhetoric, the report argues, serves to veil women and men’s different opportunities to combine family and work.
Projected nonlinear least squares for exponential fitting
Creators: name: Hokanson, Jeffrey M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 11L03, 62K99, 65K10, 90C55

description: The modern ability to collect vast quantities of data poses a challenge for parameter estimation problems. When posed as a nonlinear least squares problem fitting a model to data, the cost of each iteration grows linearly with the amount of data and it can easily become prohibitively expensive to perform many iterations. Here we develop an approach that projects the data onto a low-dimensional subspace of the high-dimensional data that preserves the information in the original data. We provide results from both optimization and statistical perspectives showing that the information is preserved when the subspace angles between this projection and the Jacobian of the model at the current iterate remain small. However, for this approach to reduce computational complexity, both the projected model and Jacobian must be computed inexpensively. This is a constraint on the pairs of models and subspaces for which this approach provides a computational speedup. Here we consider the exponential fitting problem projected onto the range of Vandermonde matrix, for which the projected model and Jacobian can be computed in closed form using a generalized geometric sum formula. We further provide an inexpensive heuristic that picks this Vandermonde matrix so that the subspace angles with the Jacobian remain small and use this heuristic to update the subspace during optimization. Although the asymptotic cost still depends on the data dimension, the overall cost of this sequence of projected nonlinear least squares problems is less expensive than the original nonlinear least squares problem. Applied to the exponential fitting problem, this provides an algorithm that is not only faster in the limit of large data than the conventional nonlinear least squares approach, but is also faster than subspace based approaches such as HSVD.
Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis
Creators: name: Patel, G.
name: Tamayo, R.
name: van Bakel, H.
name: Huprikar, S.
name: Touchon, M.
name: Sekulovic, O.
name: Bashir, A.
name: Beckford, C.
name: Deikus, G.
name: Hamula, C.
name: Sebra, R.
name: Lewis-Sandari, M.
name: Mead, E.A.
name: Wallach, F.
name: Bunyavanich, S.
name: Zeitouni, N.E.
name: Trzilova, D.
name: Kim, A.
name: Zhu, S.
name: Oliveira, P.H.
name: Ribis, J.W.
name: Fang, G.
name: Altman, D.R.
name: Pak, T.
name: Aggarwal, A.K.
name: Schadt, E.E.
name: Kasarskis, A.
name: Shen, A.
name: Webster, E.
name: Garrett, E.M.
name: Oussenko, I.
Publisher: name: Nature Research
Year: 2020

description: Clostridioides (formerly Clostridium) difficile is a leading cause of healthcare-associated infections. Although considerable progress has been made in the understanding of its genome, the epigenome of C. difficile and its functional impact has not been systematically explored. Here, we perform a comprehensive DNA methylome analysis of C. difficile using 36 human isolates and observe a high level of epigenomic diversity. We discovered an orphan DNA methyltransferase with a well-defined specificity, the corresponding gene of which is highly conserved across our dataset and in all of the approximately 300 global C. difficile genomes examined. Inactivation of the methyltransferase gene negatively impacts sporulation, a key step in C. difficile disease transmission, and these results are consistently supported by multiomics data, genetic experiments and a mouse colonization model. Further experimental and transcriptomic analyses suggest that epigenetic regulation is associated with cell length, biofilm formation and host colonization. These findings provide a unique epigenetic dimension to characterize medically relevant biological processes in this important pathogen. This study also provides a set of methods for comparative epigenomics and integrative analysis, which we expect to be broadly applicable to bacterial epigenomic studies.
(3502) Kate Scowen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
[PDF/Kindle] ¿TÚ LO HARÍAS? descargar gratis
Creators: name: Fowler
Publisher: name: Zenodo
Year: 2024

description: ¿TÚ LO HARÍAS? de MEGAN MAXWELL

Descargar eBook gratis ➡ Link

Ficha técnica

¿TÚ LO HARÍAS?

MEGAN MAXWELL

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408279181

Editorial: PLANETA

Año de edición: 2023

 

 

 

 

 

Descarga gratuita de audiolibros en inglés. ¿TÚ LO HARÍAS? (Literatura española) de MEGAN MAXWELL

 

Overview

Adéntrate en esta comedia romántica y verás como las decepciones amorosas no se superan con lágrimas, sino con la seguridad absoluta de que no hay nadie más fuerte que una mujer que aprende a reconstruirse a sí misma.¿Tú lo harías? nos presenta a tres mujeres de poco más de treinta años que aparentemente no tienen nada en común. África es periodista, aunque la ilusión de su vida es ser editora. Gema está especializada en marketing y publicidad y es madre de dos hijos. Belinda es limpiadora en hoteles y hospitales. Ellas no se conocen de nada, hasta que un buen día coinciden en un local llamado Bébete a Tu Ex. A partir de ese momento forjarán una amistad que las ayudará a hacer frente a las distintas decepciones que han sufrido por amor y, ante una botellita de vino, se retarán a vivir la vida uno o varios puntitos más allá de hasta donde se habían atrevido a hacerlo. Eso significará un ¡ADIÓS! a los miedos y vergüenzas, especialmente al qué dirán, y un gran ¡HOLA! a vivir, atreverse, quererse y disfrutar. Porque por muchas veces que hagas caer a una mujer en su camino, ella siempre se levantará, se sacudirá el polvo y se hará más fuerte.
Single cell analysis of nutrient regulation of Clostridioides (Clostridium) difficile motility
Creators: name: Cheney, R.E.
name: Rinehold, A.J.
name: Madrill, M.
name: Pokhrel, A.
name: Purcell, E.B.
name: Scott, C.
name: Courson, D.S.
name: Tamayo, R.
Publisher: name: Academic Press
Year: 2019

description: Regulation of bacterial motility to maximize nutrient acquisition or minimize exposure to harmful substances plays an important role in microbial proliferation and host colonization. The technical difficulties of performing high-resolution live microscopy on anaerobes have hindered mechanistic studies of motility in Clostridioides (formerly Clostridium) difficile. Here, we present a widely applicable protocol for live cell imaging of anaerobic bacteria that has allowed us to characterize C. difficile swimming at the single-cell level. This accessible method for anaerobic live cell microscopy enables inquiry into previously inaccessible aspects of C. difficile physiology and behavior. We present the first report that vegetative C. difficile are capable of regulated motility in the presence of different nutrients. We demonstrate that the epidemic C. difficile strain R20291 exhibits regulated motility in the presence of multiple nutrient sources by modulating its swimming velocity. This is a powerful illustration of the ability of single-cell studies to explain population-wide phenomena such as dispersal through the environment.
ENSURING EMPLOYMENT IN THE REPUBLIC OF UZBEKISTAN
Creators: name: Abdujalilova, Oyzoda
Publisher: name: Zenodo
Year: 2025

description: This article is dedicated to the issue of ensuring employment in the Republic of Uzbekistan. It discusses employment, job creation, aligning supply and demand in the labor market, ensuring youth and women’s employment, and measures aimed at increasing employment in rural areas. Ensuring employment plays a significant role in achieving economic stability and social well-being. The article presents strategic directions and proposals for increasing employment. Small and medium-sized business development, updating the education system, and involving youth and women in employment are identified as key factors in solving employment problems.
Cyclic diguanylate riboswitches control bacterial pathogenesis mechanisms
Creators: name: Tamayo, R.
Publisher: name: Public Library of Science
Year: 2019

description: Many bacterial species use cyclic diguanylate (c-di-GMP) to control their physiology and behaviors in response to extracellular stimuli. C-di-GMP primarily mediates the switch between a free-living, motile state and a nonmotile lifestyle, with the latter often entailing surface adherence and biofilm development. This paradigm is conserved across diverse gram-positive and gram-negative species, though the specific extracellular signals that impact c-di-GMP levels and the response mechanisms employed vary. Because c-di-GMP affects motility and adherence, it consequently can influence bacterial pathogenicity. In addition, a number of pathogenic bacteria have engaged c-di-GMP signaling to control specific virulence mechanisms, including effector secretion mechanisms and toxin biosynthesis.
title: Changes in Healthy Eating and Physical Activity Behaviors of Adult Participants in Create Better Health's Education (SNAP-Ed) Program
Creators: name: Bullock, Kami
Publisher: name: Utah State University
Year: 2022

description: The purpose of this study was to compare the effects of delivery method on the nutrition, food resource management (FRM), and physical activity behavior of participants enrolled in either Create Better Health’s in-person or online courses. The pre-survey and post-survey included data on nutrition, FRM, and physical activity behaviors. The researcher analyzed preexisting data from 138 SNAP-eligible adults who participated in Create Better Health’s online and in-person courses.
Results showed similar improvements in most of the nutrition and physical activity behaviors among those who took the CBH courses online or in-person. The online course showed statistically higher scores for four of the six FRM skills as well as drinking sweetened beverages.
Recommendations for continued research on the effects of the online and in-person Create Better Health courses is recommended. Similar sample sizes for the online and in-person course and data collected when not affected by a pandemic may show different results. The research recommends tailoring the modality to target populations based on needs, interests, and demographics. Technology is becoming more widely used among individuals with low income and research shows that web-based nutrition education can be just as effective or more effective than traditional direct education interventions among populations with low income.
The findings should encourage Extension and other programs that provide nutrition education for individuals with low income to utilize and continue the use of web-based programming using the CBH online course as a model. The USDA FNS’s policy, systems, and environmental framework, social cognitive theory, and social ecological model can serve as a guide for evaluating and creating programs that influence nutrition and physical activity change.
title: Masculinity, Affirmations, Belongingness, and Resiliency in Male Adolescents: Effects on School Engagement
Creators: name: Burt, Kelsey
Publisher: name: Utah State University
Year: 2022

description: This study focused on male adolescent students within 7th and 8th grade and how endorsement of masculine stereotypes impacts their school engagement and feelings of belonging. The study also examines how peers maintain masculine conformity and how individual resiliency change outcomes. This research is based on two main theories, inclusive masculinity and social learning theory. These theories describe how behaviors are largely learned from the social environment and maintained due to reinforcement or punishment. There were 127 adolescent males who participated in this study and were recruited through an online survey system. Results of the study show that participants felt that endorsement of masculine stereotypes was more driven by peer expectations than their own personal expectations. Analyses showed that creating dominance from a lack of emotional vulnerability decreased feelings of peer support as well as a decrease in feelings of isolation. Avoiding femininity also decreased classroom comfort at school. Findings also show that feelings of belonging significantly impact engagement at school and resiliency significantly increased positive feelings about academic success and happiness at school (emotional engagement). Limitations and implications for future research and practice are discussed within this paper.
title: http://romatrepress.uniroma3.it/wp-content/uploads/2019/05/Un%E2%80%99altra-giovinezza.-New-Hollywood-e-New-New-Hollywood-tra-moderno-e-postmoderno.pdf
Creators: name: Zagarrio, Vito
Publisher: name: Roma TrE-Press
Year: 2016

description: Il titolo del saggio gioca con quello italiano del film di Francis Ford Coppola e con l’’eterna giovinezza’ del cinema hollywoodiano dall’inizio degli anni Settanta a oggi, sospeso tra «moderno» e «postmoderno». Se la New Hollywood nasceva grazie a degli ‘innesti’ della Nouvelle Vague, del post-neorealismo, della modernità europea, la cosiddetta New-New Hollywood deve necessariamente giocare con la post-modernità (e con la post-post-modernità). Filo rosso tra le due ere, e tra moderno e postmoderno, è appunto Coppola, che prima ‘civetta’ col cinema autoriale europeo e (auto)riflette sul linguaggio cinematografico, poi costruisce il suo universo citatorio postmodernista. Un’altra giovinezza si inserisce nella tendenza del puzzle film tipica del tardo post-moderno, rompe la narrazione tradizionale e riflette sulle origini stesse del linguaggio (verbale e filmico).
description: Modernità nelle Americhe
(3503) Mabel Penny
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Cultural, Contextual, and Individual Determinants of Mental Health Service Utilization Among Latinx Emerging Adults
Creators: name: Carrera Diaz, Kenia
Publisher: name: Utah State University
Year: 2022

description: Despite being at an increased risk of experiencing mental health problems, Latinx emerging adults underutilize professional psychological services compared to other ethnic/racial groups. It is important for researchers to understand this mental health disparity to improve Latinx emerging adults’ use of quality mental health services (MHS). The current project investigated factors that might influence Latinx emerging adult’s use of MHS through two separate studies. In the first study, I systematically reviewed research published in the past decade that examined predictors of MHS use among Latinx emerging adults. A total of 9 studies were found and included in this review. This systematic review highlighted several factors that increased or decreased the likelihood or extent of Latinx emerging adults’ use of MHS. These factors included mental health stigma, perceived helpfulness of treatment, insurance coverage, perceived need, and knowledge of available resources. Among these, mental health stigma was often rated as a barrier to seeking psychological treatment among Latinx emerging adults. In the second study, I explored how cultural factors, like language use and how much people identified with being Latinx, and emotional factors, including emotion regulation and expression, might influence Latinx college students’ stigma and negative attitudes towards seeking professional psychological help. Results from this study showed that limited emotion expression and difficulties with emotion regulation predicted greater stigma and negative attitudes towards seeking professional psychological help. On the other hand, higher English language use and adherence to ethnic identity were associated with less stigma and negative attitudes towards seeking professional psychological help among Latinx college students. Based on the results from both studies, suggestions for clinical practice and future research are offered.
A dynamic and statistical analysis of the temperature- and fatigue behavior of a race power unit – The effect of different thermodynamic states
Creators: name: Hölz, Peter
Publisher: name: KIT Scientific Publishing
Year: 2020
Subjects: Modellreduktion
Konjugierte Wärmeübertragung
Motorwärmeübertragung
Transiente Simulation
Wärmemanagement
Model reduction
Conjugate heat transfer
Engine heat transfer
Transient simulation
Thermal management

description: In this work, the dynamic behavior of a lean combustion race engine is investigated with regard to cycle-averaged component temperatures, heat fluxes and piston failure under high cycle fatigue loading. A special focus lies on the influence of various engine settings, like ignition time and the airfuel ratio. For the introduced stationary, as well as transient, temperature calculation method, in cylinder pressure curves are measured and processed statistically by probability density functions.
Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence
Creators: name: Wetzel, D.
name: Jones, J.B.
name: McBride, S.M.
name: Garrett, E.M.
name: Edwards, A.N.
name: Sekulovic, O.
name: Tamayo, R.
name: Vargas-Cuebas, G.
Publisher: name: Public Library of Science
Year: 2019

description: Recent work has revealed that Clostridioides difficile, a major cause of nosocomial diarrheal disease, exhibits phenotypic heterogeneity within a clonal population as a result of phase variation. Many C. difficile strains representing multiple ribotypes develop two colony morphotypes, termed rough and smooth, but the biological implications of this phenomenon have not been explored. Here, we examine the molecular basis and physiological relevance of the distinct colony morphotypes produced by this bacterium. We show that C. difficile reversibly differentiates into rough and smooth colony morphologies and that bacteria derived from the isolates display discrete motility behaviors. We identified an atypical phase-variable signal transduction system consisting of a histidine kinase and two response regulators, named herein colony morphology regulators RST (CmrRST), which mediates the switch in colony morphology and motility behaviors. The CmrRST-regulated surface motility is independent of flagella and type IV pili, suggesting a novel mechanism of cell migration in C. difficile. Microscopic analysis of cell and colony structure indicates that CmrRST promotes the formation of elongated bacteria arranged in bundled chains, which may contribute to bacterial migration on surfaces. In a hamster model of acute C. difficile disease, the CmrRST system is required for disease development. Furthermore, we provide evidence that CmrRST phase varies during infection, suggesting that the intestinal environment impacts the proportion of CmrRST-expressing C. difficile. Our findings indicate that C. difficile employs phase variation of the CmrRST signal transduction system to generate phenotypic heterogeneity during infection, with concomitant effects on bacterial physiology and pathogenesis.