cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A negative selection heuristic to predict new transcriptional targets
Creators: name: Cerulo, Luigi
name: Paduano, Vincenzo
name: Zoppoli, Pietro
name: Ceccarelli, Michele
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Computer science

description: Background: Supervised machine learning approaches have been recently adopted in the inference of transcriptional targets from high throughput trascriptomic and proteomic data showing major improvements from with respect to the state of the art of reverse gene regulatory network methods. Beside traditional unsupervised techniques, a supervised classifier learns, from known examples, a function that is able to recognize new relationships for new data. In the context of gene regulatory inference a supervised classifier is coerced to learn from positive and unlabeled examples, as the counter negative examples are unavailable or hard to collect. Such a condition could limit the performance of the classifier especially when the amount of training examples is low. Results: In this paper we improve the supervised identification of transcriptional targets by selecting reliable counter negative examples from the unlabeled set. We introduce an heuristic based on the known topology of transcriptional networks that in fact restores the conventional positive/negative training condition and shows a significant improvement of the classification performance. We empirically evaluate the proposed heuristic with the experimental datasets of Escherichia coli and show an example of application in the prediction of BCL6 direct core targets in normal germinal center human B cells obtaining a precision of 60%. Conclusions: The availability of only positive examples in learning transcriptional relationships negatively affects the performance of supervised classifiers. We show that the selection of reliable negative examples, a practice adopted in text mining approaches, improves the performance of such classifiers opening new perspectives in the identification of new transcriptional targets.
The XMM-Newton spectrum of a candidate recoiling supermassive black hole: an elusive inverted P-Cygni profile
Creators: name: Lanzuisi, G.
name: Civano, F.
name: Marchesi, S.
name: Comastri, A.
name: Costantini, E.
name: Elvis, M.
name: Mainieri, V.
name: Hickox, R.
name: Jahnke, K.
name: Komossa, S.
name: Piconcelli, E.
name: Vignali, C.
name: Brusa, M.
name: Cappelluti, N.
name: Fruscione, A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a detailed spectral analysis of new XMM-Newton data of the source CXOC J100043.1+020637, also known as CID-42, detected in the COSMOS survey at z = 0.359. Previous works suggested that CID-42 is a candidate recoiling supermassive black holes showing also an inverted P-Cygni profile in the X- ray spectra at ~6 keV (rest) with an iron emission line plus a redshifted absorption line (detected at 3sigma in previous XMM-Newton and Chandra observations). Detailed analysis of the absorption line suggested the presence of ionized material inflowing into the black hole at high velocity. In the new long XMM-Newton observation, while the overall spectral shape remains constant, the continuum 2-10 keV flux decreased of ~20% with respect to previous observation and the absorption line is undetected. The upper limit on the intensity of the absorption line is EW<162 keV. Extensive Monte Carlo simulations show that the non detection of the line is solely due to variation in the properties of the inflowing material, in agreement with the transient nature of these features, and that the intensity of the line is lower than the previously measured with a probability of 98.8%. In the scenario of CID-42 as recoiling SMBH, the absorption line can be interpreted as due to inflow of gas with variable density and located in the proximity of the SMBH and recoiling with it. New monitoring observations will be requested to further characterize this line.
description: 11 pages, 7 figures, 2 tables; Accepted for publication on ApJ on October 3rd
title: [Zweiteilige Sammelhandschrift]; 1468-1469
title: (Vorderdeckel) Inhaltsverzeichnis. (1r) Register zum Solinustext. (11v) G. Iulius Solinus: Collectanea rerum memorabilium sive polyhistor. (106v) Johannes Boccacius: De claris mulieribus. (107r) Pomponius Mela: De chronographia.
titleType: Subtitle
Creators: name: Solinus, Gaius Iulius
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2022

description: lokalisierende und datierende Schreibervermerke (106v und 152v)
Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer
Creators: name: Ling, C. Clifton
name: Zanzonico, Pat B.
name: Leibold, Tobias
name: Carlin, Sean D.
name: Cai, Shangde
name: Burnazi, Eva M.
name: Lee-Kong, Steven Albert
name: Ruby, Jeannine A.
name: Humm, John L.
name: Guillem, José G.
name: Schöder, Heiko
name: Lee, Nancy Y.
name: Divgi, Chaitanya R.
name: O'Donoghue, Joseph A.
Publisher: name: Columbia University
Year: 2013
Subjects: Oncology
Surgery

description: Background: Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in patients with advanced colorectal cancer and head and neck cancer using serial positron emission tomography (PET) imaging. Methods: Ten patients underwent serial whole-torso (head/neck to pelvis) PET imaging together with multiple whole-body counts and blood sampling. These data were used to generate absorbed dose estimates to normal tissues for 124I-IAZGP. Tumors were scored as either positive or negative for 124I-IAZGP uptake. Results: There were no clinical toxicities or adverse effects associated with 124I-IAZGP administration. Clearance from the whole body and blood was rapid, primarily via the urinary tract, with no focal uptake in any parenchymal organ. The tissues receiving the highest absorbed doses were the mucosal walls of the urinary bladder and the intestinal tract, in particular the lower large intestine. All 124I-IAZGP PET scans were interpreted as negative for tumor uptake. Conclusions: It is safe to administer 124I-IAZGP to human subjects. However, there was insufficient tumor uptake to support a clinical role for 124I-IAZGP PET in colorectal cancer and head and neck cancer patients. Trial registration: ClinicalTrials.gov NCT00588276
The paradox paradox
Creators: name: Brock, Stuart
name: Glasgow, J
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 220299 History and Philosophy of Specific Fields not elsewhere classified

description: In this paper we argue that our conception of and intuitions about paradoxes are themselves paradoxical. Specifically, we argue that our commitment to the existence and nature of paradoxes is inconsistent with a norm of rationality—which is a paradox.
A Note on Analysis and Circular Definitions
Creators: name: Varzi, Achille C.
Publisher: name: Columbia University
Year: 1998
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: An analysis—in its simplest form—is an assertion aiming to capture a certain intimate link between a given concept (the analysandum) and another, typically more precise and fully explicit concept (the analysans). In some cases, even a whole theory may be regarded as a constituting an analysis. For example, Russell’s celebrated theory of definite descriptions may be viewed as an analysis of that formal concept which in natural language can be expressed by means of the definite article. Analyses are also called philosophical, real, or simply analyzing definitions.
Futibatinib: First Approval
Creators: name: Syed, Yahiya Y.
Publisher: name: Adis Journals
Year: 2022
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable Additional information about this Adis Drug Review can be found here Abstract Futibatinib (Lytgobi®) is an oral irreversible inhibitor of fibroblast growth factor receptor (FGFR)1–4 that is being developed by Taiho Oncology and Taiho Pharmaceutical for the treatment of cancers, including cholangiocarcinoma, breast cancer, gastric cancer, urothelial cancer and non-small cell lung cancer. Futibatinib was approved in the USA on 30 September 2022 for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harbouring FGFR2 gene fusions or other rearrangements. This article summarizes the milestones in the development of futibatinib leading to this first approval. © Springer Nature Switzerland AG 2022
Spirometry and regular follow-up do not improve quality of life in children or adolescents with asthma: Cluster randomized controlled trials
Creators: name: Beilby, Justin
name: Abramson, Michael
name: Schattner, Rosa L.
name: C Holton
name: P Simpson
name: N Briggs
name: M Nelson
name: Wood-Baker, Richard
name: F Thein
name: NABIL SULAIMAN
name: E Colle
name: R Wolfe
name: Crockett, Alan
name: R Massie
Publisher: name: Torrens University Australia
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Clinical Trial Registration: ACTRN12606000378527, ACTRN12606000093583.The trials were conceived and designed by Michael Abramson, Christine Holton, Justin Beilby, Mark Nelson, Richard Wood‐Baker, Francis Thien, Nabil Sulaiman, Eleonora Del Colle, Rory Wolfe, Alan J. Crockett, and John Massie. Data collection was conducted by Rosa Schattner, Eleonora Del Colle, and Christine Holton with the assistance of others acknowledged. Data analysis was performed by Pam Simpson, Nancy Briggs, and Rory Wolfe. Findings were interpreted by Michael Abramson, Christine Holton, Rory Wolfe, Alan Crockett, and John Massie. All authors contributed to drafting the article or revising it critically for important intellectual content, and give final approval of the version to be published. Michael Abramson and Alan Crockett are guarantors of the paper.NHMRC played no part in the design or conduct of the trials, analysis of data, or decision to publish findings.
Surface differential rotation of IL Hya from time-series Doppler images
Creators: name: Kővári, Zsolt
name: Kriskovics, Levente
name: Oláh, Katalin
name: Vida, Krisztián
name: Bartus, János
name: Strassmeier, Klaus G.
name: Weber, Michael
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a time-series Doppler imaging study of the K-subgiant component in the RS CVn-type binary system IL Hya (P orb=12.905 d). From re-processing the unique long-term spectroscopic dataset of 70 days taken in 1996/97, we perform a thorough cross-correlation analysis to derive surface differential rotation. As a result we get solar-type differential rotation with a shear value alpha of 0.05, in agreement with preliminary suggestions from previous attempts. A possible surface pattern of meridional circulation is also detected.
description: 2 pages, 2 figures, to be appeared in "Magnetic Fields Throughout the Stellar Evolution", Proc. IAU Symp. 302
Clinical care for sexual assault survivors multimedia training: a mixed-methods study of effect on healthcare providers’ attitudes, knowledge, confidence, and practice in humanitarian settings
Creators: name: Smith, Janel R.
name: Ho, Lara
name: Langston, Anne
name: Mankani, Neha
name: Shivshanker, Anjuli
name: Perera, Dhammika
Publisher: name: Columbia University
Year: 2013
Subjects: Public health
Health services administration
Medical care

description: Background: Sexual assault is a threat to public health in refugee and conflict affected settings, placing survivors at risk for unintended pregnancy, unsafe abortion, STIs, HIV, psychological trauma, and social stigma. In response, the International Rescue Committee developed a multimedia training tool to encourage competent, compassionate, and confidential clinical care for sexual assault survivors in low-resource settings. This study evaluated the effect of the training on healthcare providers’ attitudes, knowledge, confidence, and practices in four countries. Methods: Using a mixed-methods approach, we surveyed a purposive sample of 106 healthcare providers before and 3 months after training to measure attitudes, knowledge, and confidence. In-depth interviews with 40 providers elaborated on survey findings. Medical record audits were conducted in 35 health facilities before and 3 months after the intervention to measure healthcare providers’ practice. Quantitative and qualitative data underwent statistical and thematic analysis. Results: While negative attitudes, including blaming and disbelieving women who report sexual assault, did not significantly decrease among healthcare providers after training, respect for patient rights to self-determination and non-discrimination increased from 76% to 91% (p
Dorzagliatin: First Approval
Creators: name: Syed, Yahiya Y.
Publisher: name: Adis Journals
Year: 2022
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable Additional information about this Adis Drug Review can be found here Abstract Dorzagliatin (HuaTangNing) is an oral glucokinase activator that is being developed by Hua Medicine for the treatment of type 2 diabetes mellitus (T2DM), type 1 diabetes mellitus (T1DM) and diabetic kidney disease (DKD). Dorzagliatin improves glycaemic control by activating pancreatic and hepatic glucokinase in a glucose-dependent manner. In September 2022, dorzagliatin (with diet control and exercise) as monotherapy and as an add-on to metformin (when glycaemic control is inadequate with metformin alone) was approved in China for improving glycaemic control in adult patients with T2DM. This article summarizes the milestones in the development of dorzagliatin leading to this first approval. © Springer Nature Switzerland AG 2022
The Niche
Creators: name: Smith, Barry
name: Varzi, Achille C.
Publisher: name: Columbia University
Year: 1999
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Logic

description: The concept of niche (setting, context, habitat, environment) has been little studied by ontologists, in spite of its wide application in a variety of disciplines from evolutionary biology to economics. What follows is a first formal theory of this concept, a theory of the relations between objects and their niches. The theory builds upon existing work on mereology, topology, and the theory of spatial location as tools of formal ontology. It is illustrated above all by means of simple biological examples, but the concept of niche should be understood as being, like concepts such as part, boundary, and location, a structural concept that is applicable in principle to a wide range of different domains.
Slowly varying control parameters, delayed bifurcations and the stability of spikes in reaction-diffusion systems
Creators: name: Tzou, Justin C.
name: Ward, Michael J.
name: Kolokolnikov, Theodore
Publisher: name: arXiv
Year: 2014
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences
subject: 35K57, 35B36 (primary) 35B35, 35B32, 35B25 (secondary)

description: We present three examples of delayed bifurcations for spike solutions of reaction-diffusion systems. The delay effect results as the system passes slowly from a stable to an unstable regime, and was previously analysed in the context of ODE's in [P.Mandel, T.Erneux, J.Stat.Phys, 1987]. It was found that the instability would not be fully realized until the system had entered well into the unstable regime. The bifurcation is said to have been "delayed" relative to the threshold value computed directly from a linear stability analysis. In contrast, we analyze the delay effect in systems of PDE's. In particular, for spike solutions of singularly perturbed generalized Gierer-Meinhardt (GM) and Gray-Scott (GS) models, we analyze three examples of delay resulting from slow passage into regimes of oscillatory and competition instability. In the first example, for the GM model on the infinite real line, we analyze the delay resulting from slowly tuning a control parameter through a Hopf bifurcation. In the second example, we consider a Hopf bifurcation on a finite one-dimensional domain. In this scenario, as opposed to the extrinsic tuning of a system parameter through a bifurcation value, we analyze the delay of a bifurcation triggered by slow intrinsic dynamics of the PDE system. In the third example, we consider competition instabilities of the GS model triggered by the extrinsic tuning of a feed rate parameter. In all cases, we find that the system must pass well into the unstable regime before the onset of instability is fully observed, indicating delay. We also find that delay has an important effect on the eventual dynamics of the system in the unstable regime. We give analytic predictions for the magnitude of the delays as obtained through analysis of certain explicitly solvable nonlocal eigenvalue problems. The theory is confirmed by numerical solutions of the full PDE systems.
description: 31 pages, 20 figures, submitted to Physica D: Nonlinear Phenomena
The application of artificial intelligence (AI) techniques to identify frailty within a residential aged care administrative data set
Creators: name: Ambagtsheer, Rachel C.
name: N. Shafiabady
name: Dent, Elsa
name: C. Seiboth
name: Beilby, Justin
Publisher: name: Torrens University Australia
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Introduction: Research has shown that frailty, a geriatric syndrome associated with an increased risk of negative outcomes for older people, is highly prevalent among residents of residential aged care facilities (also called long term care facilities or nursing homes). However, progress on effective identification of frailty within residential care remains at an early stage, necessitating the development of new methods for accurate and efficient screening. Objectives: We aimed to determine the effectiveness of artificial intelligence (AI) algorithms in accurately identifying frailty among residents aged 75 years and over in comparison with a calculated electronic Frailty Index (eFI) based on a routinely-collected residential aged care administrative data set drawn from 10 residential care facilities located in Queensland, Australia. A secondary objective included the identification of best-performing candidate algorithms. Methods: We designed a frailty prediction system based on the eFI identification of frailty, allocating 84.5 % and 15.5 % of the data to training and test data sets respectively. We compared the performance of 18 specific scenarios to predict frailty against eFI based on unique combinations of three ML algorithms (support vector machines [SVM], decision trees [DT] and K-nearest neighbours [KNN]) and six cases (6, 10, 11, 14, 39 and 70 input variables). We calculated accuracy, percentage positive and negative agreement, sensitivity, specificity, Cohen's kappa and Prevalence- and Bias- Adjusted Kappa (PABAK), table frequencies and positive and negative predictive values. Results: Of 592 eligible resident records, 500 were allocated to the training set and 92 to the test set. Three scenarios (10, 11 and 70 input variables), all based on SVM algorithm, returned overall accuracy above 75 %. Conclusions: There is some potential for AI techniques to contribute towards better frailty identification within residential care. However, potential benefits will need to be weighed against administrative burden, data quality concerns and presence of potential bias.
Comoediae VI; [Mitte 15. Jahrhundert]
Creators: name: Terentius Afer, Publius
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2022

description: Papier. – Italienische Gothica humanistica von einer Hand, Interlinear- und Randglossen von mehreren Händen, Überschriften und Nomina rot, Drôlerien (57v, 62v, 64v, 69v, 77v, 97v, 98r, 127v, 129r, 136r und 139v)
Community Recommendations for Improving Sustainable Scientific Software Practices
Creators: name: Downs, Robert R.
name: Lenhardt, W. Christopher
name: Robinson, Erin
name: Davis, Ethan
name: Weber, Nicholas
Publisher: name: Columbia University
Year: 2014
Subjects: Information science
Computer science

description: Multiple focus groups were conducted to elicit perspectives from members of the Earth science informatics community on the sustainability of scientific software. Recommendations that the participants offered for near-term community actions and activities are described.
Domain wall trajectory determined by its fractional topological edge defects
Creators: name: Pushp, Aakash
name: Phung, Timothy
name: Rettner, Charles
name: Hughes, Brian P.
name: Yang, See-Hun
name: Thomas, Luc
name: Parkin, Stuart S. P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: A domain wall (DW) in a ferromagnetic nanowire is composed of elementary topological bulk and edge defects with integer and fractional winding numbers, respectively, whose relative spatial arrangement determines the chirality of the DW. Here we show how we can understand and control the trajectory of DWs in magnetic branched networks, composed of connected nanowires, by considering their fractional elementary topological defects and how they interact with those innate to the network. We first develop a highly reliable mechanism for the injection of a DW of a given chirality into a nanowire and show that its chirality determines which branch the DW follows at a symmetric Y-shaped magnetic junction - the fundamental building block of the network. Using these concepts, we unravel the origin of the one-dimensional nature of magnetization reversal of connected artificial spin ice systems that have been observed in the form of Dirac strings.
description: preprint version, excluding supplementary online material and movies
Aquisição de competências transversais pela elaboração de propostas de candidaturas a financiamento de projetos de Comunicação de Ciência ou de Atividades de Ciência pelos estudantes de Ciências farmacêuticas
Creators: name: Cavadas, Claudia
Publisher: name: Zenodo
Year: 2021
Subjects: Competências transversais

description: Apresentação Oral - RESUMO No âmbito da unidade curricular de opção “Investigação e Comunicação de Ciência”, do 4º ano de Ciências Farmacêuticas, os estudantes, em grupo, são desafiados a elaborar uma proposta de Projeto de Comunicação de Ciência de temas previamente disponibilizados pela equipa docente, (ex: senescência celular, Ritmo Circadiano, etc) ou relacionados com a atividade de investigação científica (Ética e Integridade Científica, A investigação no feminino, etc), com o objetivo de desenvolvimento de competências transversais. O projeto contem a lista de items semelhantes a uma candidatura a financiamento competitivo, a uma agência financiadora ou investidor: contexto e objetivo do projeto, Público alvo, Conteúdo a divulgar; Descrição do Projeto; Formas de divulgação/materiais ou formatos a desenvolver ou a implementar; Orçamento ; Equipa (funções de cada elemento da equipa); Cronograma, Milestones e Deliverables. Cada grupo apresentou oralmente a sua proposta de projeto, recolheram sugestões e elaboraram a proposta final. Foi valorizado a capacidade de integração de melhorias propostas no trabalho final. Esta atividade pedagógica permitiu a aquisição de diversas competências transversais pelos estudantes, como mostram os resultados preliminares já obtidos.
Feasibility and acceptability of commonly used screening instruments to identify frailty among community-dwelling older people
Creators: name: Ambagtsheer, Rachel
name: Archibald, Mandy
name: Lawless, Michael
name: Kitson, Alison
name: Beilby, Justin
Publisher: name: Torrens University Australia
Year: 2020
Subjects: subject: 110399 Clinical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Background: Frailty exposes older people to an elevated risk of a range of negative outcomes. Emerging evidence that frailty can be effectively treated within community settings has stimulated calls for more proactive screening within primary care. Assessing feasibility is a critical preliminary step in assessing the efficacy of interventions such as screening. However, few studies have explored the feasibility and acceptability of administering frailty screening instruments within general practice, and even fewer have incorporated patient perspectives. Our study had three objectives: To 1) assess overall feasibility of the instruments (completion time and rate); 2) assess patient acceptability towards the instruments; and 3) assess the feasibility and acceptability of the instruments to administering nurses. Methods: The feasibility and acceptability of several frailty screening instruments (PRISMA-7, Edmonton Frail Scale, FRAIL Scale Questionnaire, Gait Speed, Groningen Frailty Indicator, Reported Edmonton Frail Scale and Kihon Checklist) was explored within the context of a larger diagnostic test accuracy (DTA) study. Completion time and rate was collected for all participants (N = 243). A sub-sample of patients (n = 30) rated each instrument for ease of completion and provided comment on perceived acceptability. Lastly, five of six administering nurses involved in the DTA study participated in semi-structured face-to-face interviews, rating the instruments against several feasibility and acceptability criteria (time, space, equipment, skill required to implement, acceptability to patients and nurses, ease of scoring) and providing comment on their responses. Results: The PRISMA-7 returned the highest overall feasibility and acceptability, requiring minimal space, equipment, skills and time to implement, and returning the fastest completion rate and highest patient and nurse acceptability rating. All screening instruments were faster to implement than the two reference standards (Fried's Frailty Phenotype and Frailty Index). Self-administered instruments were subject to lower rates of completion than nurse-administered instruments. Conclusions: This study has demonstrated that a number of commonly used frailty screening instruments are potentially feasible for implementation within general practice. Ultimately, more research is needed to determine how contextual factors, such as differences in individual patient and clinician preferences, setting and system factors, impact on the feasibility of screening in practice.
Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens
Creators: name: Manders, Toby R.
name: Ziff, Edward B.
name: Wang, Jing
name: Turkey, David S.
name: Lee, Michelle
name: Xu, Duo
name: Eberle, Sarah E.
name: Goffer, Yossef
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Biochemistry
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Pain and natural rewards such as food elicit different behavioral effects. Both pain and rewards, however, have been shown to alter synaptic activities in the nucleus accumbens (NAc), a key component of the brain reward system. Mechanisms by which external stimuli regulate plasticity at NAc synapses are largely unexplored. Medium spiny neurons (MSNs) from the NAc receive excitatory glutamatergic inputs and modulatory dopaminergic and cholinergic inputs from a variety of cortical and subcortical structures. Glutamate inputs to the NAc arise primarily from prefrontal cortex, thalamus, amygdala, and hippocampus, and different glutamate projections provide distinct synaptic and ultimately behavioral functions. The family of vesicular glutamate transporters (VGLUTs 1–3) plays a key role in the uploading of glutamate into synaptic vesicles. VGLUT1-3 isoforms have distinct expression patterns in the brain, but the effects of external stimuli on their expression patterns have not been studied. Results: In this study, we use a sucrose self-administration paradigm for natural rewards, and spared nerve injury (SNI) model for chronic pain. We examine the levels of VGLUTs (1–3) in synaptoneurosomes of the NAc in these two behavioral models. We find that chronic pain leads to a decrease of VGLUT1, likely reflecting decreased projections from the cortex. Pain also decreases VGLUT3 levels, likely representing a decrease in projections from GABAergic, serotonergic, and/or cholinergic interneurons. In contrast, chronic consumption of sucrose increases VGLUT3 in the NAc, possibly reflecting an increase from these interneuron projections. Conclusion: Our study shows that natural rewards and pain have distinct effects on the VGLUT expression pattern in the NAc, indicating that glutamate inputs to the NAc are differentially modulated by rewards and pain.
Optical simulation of Majorana physics
Creators: name: Rodríguez-Lara, B. M.
name: Moya-Cessa, H. M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show a procedure to classically simulate the Majorana equation in 1+1 dimensions via two one-dimensional photonic crystals. We use a decomposition of the Majorana equation into two Dirac equations and propose a novel approach that uses a bi-chromatic refractive index distribution and nearest neighbor couplings of the type found in Glauber-Fock lattices. This allows us to escape the restriction of staying near the Brillouin zone imposed by the classical simulation of Dirac dynamics with bi-chromatic lattices. Furthermore, it is possible to simulate the evolution of Gaussian wavepackets under the Majorana/Dirac equation with light impinging only into the first waveguide of our bi-chromatic-Glauber-Fock lattice.
description: 10 pages, 2 figures
8 Hits
Creators: name: Tomlinson, Vanessa
Publisher: name: Griffith University
Year: 2022
Subjects: subject: 190407 Music Performance
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: 8 Hits was the outcome of an Australia Council Project Fellowship in 2013, which led to the commissioning, development, performance and documentation of 8 new solo percussion works by Cat Hope, Natasha Anderson, Lindsay Vickery, Rosemary Joy, Kate Neal, Vanessa Tomlinson, Peter Knight and Erik Griswold. These works were premiered at a live performance and broadcast at ABC Studio 420 in Brisbane, Queensland. A subsequent performance of the entire program took place at the Melbourne Recital Centre. Further performances of select works have taken place in Singapore, USA, Canada and across Australia. Other performers have incorporated these pieces into their repertoire. A recording of Cat Hope;s piece The solo percussion works commissioned for this program are; Natasha Anderson - The Snakes are Loose Erik Griswold - Stars of Ours Peter Knight - Make Them Dance Kate Neal - Self Accusation Vanessa Tomlinson - Still and Moving Paper Rosemary Joy - Fratrem Lindsay Vickery - Semantics of Redaction Cat Hope - Broken Approach View a recording of the performance here. View a recording of Fratrem by Rosemary Joy here. View a recording of the performance at Transplanted Roots here. View a recording of What Were We Thinking? here.
HMACA: Towards Proposing a Cellular Automata Based Tool for Protein Coding, Promoter Region Identification and Protein Structure Prediction
Creators: name: Sree, Pokkuluri Kiran
name: Babu, Inampudi Ramesh
name: N, SSSN Usha Devi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Human body consists of lot of cells, each cell consist of DeOxaRibo Nucleic Acid (DNA). Identifying the genes from the DNA sequences is a very difficult task. But identifying the coding regions is more complex task compared to the former. Identifying the protein which occupy little place in genes is a really challenging issue. For understating the genes coding region analysis plays an important role. Proteins are molecules with macro structure that are responsible for a wide range of vital biochemical functions, which includes acting as oxygen, cell signaling, antibody production, nutrient transport and building up muscle fibers. Promoter region identification and protein structure prediction has gained a remarkable attention in recent years. Even though there are some identification techniques addressing this problem, the approximate accuracy in identifying the promoter region is closely 68% to 72%. We have developed a Cellular Automata based tool build with hybrid multiple attractor cellular automata (HMACA) classifier for protein coding region, promoter region identification and protein structure prediction which predicts the protein and promoter regions with an accuracy of 76%. This tool also predicts the structure of protein with an accuracy of 80%.
title: Brustkrebs im fortgeschrittenen Stadium. Leben mit Brustkrebs.
Creators: name: Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ)
Publisher: name: Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Ärztliches Zentrum für Qualität in der Medizin (ÄZQ)
Year: 2011
Subjects: subject: 610 Medical sciences; Medicine

description: Kurzinformation für Patienten
Embedding Pedagogical Principles and Theories into Design Patterns
Creators: name: Chatteur, Fiona
name: Carvalho, Lucilla
name: Dong, Andy
Publisher: name: Torrens University Australia
Year: 2020
Subjects: subject: 80302 Computer System Architecture
subject: FOS: Computer and information sciences
subject: 80103 Computer Graphics
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology

description: The design of e-learning courseware is a careful balancing act between pedagogy and technology, often at the expense of pedagogy. Experts at teaching in their field are not necessarily experts at mapping classroom teaching into the online domain. One way of aiding e-learning design has been to create pattern languages, as design patterns and pedagogical patterns. Pedagogical patterns address teaching practices, but not the design of e-learning courseware. Current design patterns for e-learning courseware do not expicitly state why pedagogical theories and practices are selective to certain pattern language structures and design solutions. The problem with the current practice of prioritizing usability over pedagogically-oriented environments is that the learning experience of the entire e-learning environment may be overlooked. This is likely to compromise how learning materials are incorporated, the user-interface, modes of communication, collaboration spaces and so on. The environments may well be usable, but not achieve the pedagogical goals.
Change, Temporal Parts, and the Argument from Vagueness
Creators: name: Varzi, Achille C.
Publisher: name: Columbia University
Year: 2005
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Logic

description: The so-called ‘argument from vagueness’ is among the most powerful and innovative arguments offered in support of the view that objects are four-dimensional perdurants. The argument is defective – I submit – and in a number of ways that are worth looking into. But each ‘defect’, each gap in the argument, corresponds to a model of change that is independently problematic and that can hardly be built into the common-sense picture of the world. So once all the gaps of the argument are filled in, the three-dimensionalist is left with the burden of a response that cannot rely on a passive plea for common sense. The argument is not a threat to common sense as such; it is a threat to the three-dimensionalist faithfulness to common sense.
Opera of Objects
Creators: name: Tomlinson, Vanessa
name: Milliken, Grant
name: Griswold, Erik
Publisher: name: Griffith University
Year: 2022
Subjects: subject: 190406 Music Composition
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Opera of Objects - a newly devised collaborative composition explore the sonic nature of objects.
Modulation of the Optical Transmittance in Multilayer Graphene by an Electrical Signal
Creators: name: Benítez, J. L.
name: Mendoza, D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The modulation of the optical transmittance in multilayer graphene by means of an electrical signal in the simple configuration of coplanar electrodes is reported. Besides the fundamental frequency of modulation, higher harmonics also appear in the transmitted signal. Modulation is also observed in the optical reflectance. The modulation of the optical properties in multilayer graphene by electrical signals may be useful for the transmission of information by optical means.
description: 9 pages, 7 figures
Process evaluation of an autism-specific workplace tool for employers
Creators: name: Scott, Melissa
name: Falkmer, Marita
name: Kuzminski, Rebecca
name: Falkmer, Torbjörn
name: Girdler, Sonya
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Limited studies exist exploring employers’ capacity in hiring and supporting employees on the autism spectrum, and even fewer have considered interventions targeting employers’ skills and knowledge in enhancing employment opportunities. In response to this need, the Integrated Employment Success Tool (IESTTM) was developed and its effectiveness established in a randomized controlled trial (RCT). Furthermore, a process evaluation was conducted to determine the usability and implementation of the IESTTM. The process evaluation was conducted to determine employers’ perceived usability, implementation, and perceived barriers and facilitators in using the IESTTM. Employers (N = 29) provided their feedback via an online questionnaire. Of these, 11 participants were interviewed, further exploring their experiences. Data were analysed via descriptive statistics and thematic analysis. While employers’ frequency and usage of the IESTTM varied across workplaces, it was predominantly used to increase employers’ knowledge of autism and implement workplace strategies. A major barrier was the paper-based format of the intervention, with more than 60% of employers indicating the need for an online version. The process evaluation was a critical step in understanding why the IESTTM was effective, and how it could be further optimized for prospective employers.
Embedding Pedagogical Principlels and Theories into Design Patterns
Creators: name: Chatteur, Fiona
name: Carvalho, Lucilla
name: Dong, Andy
Publisher: name: Torrens University Australia
Year: 2018
Subjects: subject: 80302 Computer System Architecture
subject: FOS: Computer and information sciences
subject: 80103 Computer Graphics
subject: 80602 Computer-Human Interaction
subject: FOS: Psychology

description: The design of e-learning courseware is a careful balancing act between pedagogy and technology, often at the expense of pedagogy. Experts at teaching in their field are not necessarily experts at mapping classroom teaching into the online domain. One way of aiding e-learning design has been to create pattern languages, as design patterns and pedagogical patterns. Pedagogical patterns address teaching practices, but not the design of e-learning courseware. Current design patterns for e-learning courseware do not expicitly state why pedagogical theories and practices are selective to certain pattern language structures and design solutions. The problem with the current practice of prioritizing usability over pedagogically-oriented environments is that the learning experience of the entire e-learning environment may be overlooked. This is likely to compromise how learning materials are incorporated, the user-interface, modes of communication, collaboration spaces and so on. The environments may well be usable, but not achieve the pedagogical goals.
Experimental Three-Particle Quantum Nonlocality under Strict Locality Conditions
Creators: name: Erven, C.
name: Meyer-Scott, E.
name: Fisher, K.
name: Lavoie, J.
name: Higgins, B. L.
name: Yan, Z.
name: Pugh, C. J.
name: Bourgoin, J. -P.
name: Prevedel, R.
name: Shalm, L. K.
name: Richards, L.
name: Gigov, N.
name: Laflamme, R.
name: Weihs, G.
name: Jennewein, T.
name: Resch, K. J.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum correlations are critical to our understanding of nature, with far-reaching technological and fundamental impact. These often manifest as violations of Bell's inequalities, bounds derived from the assumptions of locality and realism, concepts integral to classical physics. Many tests of Bell's inequalities have studied pairs of correlated particles; however, the immense interest in multi-particle quantum correlations is driving the experimental frontier to test systems beyond just pairs. All experimental violations of Bell's inequalities to date require supplementary assumptions, opening the results to one or more loopholes, the closing of which is one of the most important challenges in quantum science. Individual loopholes have been closed in experiments with pairs of particles and a very recent result closed the detection loophole in a six ion experiment. No experiment thus far has closed the locality loopholes with three or more particles. Here, we distribute three-photon Greenberger-Horne-Zeilinger entangled states using optical fibre and free-space links to independent measurement stations. The measured correlations constitute a test of Mermin's inequality while closing both the locality and related freedom-of-choice loopholes due to our experimental configuration and timing. We measured a Mermin parameter of 2.77 +/- 0.08, violating the inequality bound of 2 by over 9 standard deviations, with minimum tolerances for the locality and freedom-of-choice loopholes of 264 +/- 28 ns and 304 +/- 25 ns, respectively. These results represent a significant advance towards definitive tests of the foundations of quantum mechanics and practical multi-party quantum communications protocols.
description: 13 pages, 8 figures
Sound of 84 Pianos
Creators: name: Tomlinson, Vanessa
Publisher: name: Griffith University
Year: 2022
Subjects: subject: 190407 Music Performance
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: 84 pianos was presented as part of the Queensland Conservatorium contribution to World Science Festival in a sub-festival called 100 Ways to Listen, in Brisbane. The work was devised by Tomlinson to explore changing acoustics through the in-situ sounding of every piano (84) in the conservatorium building. The composition was by Erik Griswold.
Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools
Creators: name: Koep, Tyler H.
name: Enders, Felicity T.
name: Pierret, Chris
name: Ekker, Stephen C.
name: Krageschmidt, Dale
name: Neff, Kevin L.
name: Lipsitch, Marc
name: Shaman, Jeffrey L.
name: Huskins, W. Charles
Publisher: name: Columbia University
Year: 2013
Subjects: Environmental health
Medical sciences

description: Background: Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks. Humidification of indoor environments may mitigate viral transmission and may be an important control strategy, particularly in schools where viral transmission is common and contributes to the spread of influenza in communities. However, the variability and predictors of AH in the indoor school environment and the feasibility of classroom humidification to levels that could decrease viral survival have not been studied. Methods: Automated sensors were used to measure temperature, humidity and CO2 levels in two Minnesota grade schools without central humidification during two successive winters. Outdoor AH measurements were derived from the North American Land Data Assimilation System. Variability in indoor AH within classrooms, between classrooms in the same school, and between schools was assessed using concordance correlation coefficients (CCC). Predictors of indoor AH were examined using time-series Auto-Regressive Conditional Heteroskedasticity models. Classroom humidifiers were used when school was not in session to assess the feasibility of increasing indoor AH to levels associated with decreased influenza virus survival, as projected from previously published animal experiments. Results: AH varied little within classrooms (CCC >0.90) but was more variable between classrooms in the same school (CCC 0.81 for School 1, 0.88 for School 2) and between schools (CCC 0.81). Indoor AH varied widely during the winter (range 2.60 to 10.34 millibars [mb]) and was strongly associated with changes in outdoor AH (p
Sonic Dreams - Extinction
Creators: name: Tomlinson, Vanessa
Publisher: name: Griffith University
Year: 2022
Subjects: subject: 190406 Music Composition
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Sonic Dreams is an open instrument composition that looks at species extinction in the Australian context. Viewed through an examination of loss or absence in our soundscape, this piece proposes imagined sounds from the perspective of individual extinct or critically endangered spieces as both a pro-active environmental stance, and as an interconnectedness to place, history and myth. Using archival research, heavily dominated by visual and descriptive materials – rarely sounded, embodied knowledge – the performers job is to reconstruct an unknowable scenario. Sonic Dreams was commissioned by Greywing Ensemble and is released on their album Nature Forms. It has also been performed by the Tomlin|Fergus Duo, The Eco-Acoustics International Congress, Easter at the Piano Mill and by numerous performers around the globe.
De coniuratione Catilinae; [Anfang 16. Jahrhundert]
Creators: name: Sallustius Crispus, Gaius
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2022

description: Papier. – spitze Bastarda von einer Hand, von gleicher Hand zahlreiche interlineare und marginale Glossen, Anfangsbuchstaben der Abschnitte über zwei bis drei Zeilen fehlen