cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From Trabi to e-mobility : industrial labour and social transformation in Eastern Germany
Creators: name: Ivanova, Katerina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 300

description: This doctoral thesis is based on the ethnographic field research that I carried out among the former and current automotive workers in Zwickau from September 2018 until October 2019. The dissertation touches on a variety of themes related to industrial and social transformations in the car industry in eastern Germany over the past 30 years. Based on my fieldwork and on the literature on postsocialism, industrial labour and populism both within and outside of the field of social anthropology, I show that the workers have experienced various forms of disenfranchisement and devaluation, including the decline in social status, devaluation of socialist production, the economic and symbolic hegemony of the West. Together with the weakening of the labour movements, neoliberalisation, uneven development and the threats of capitalist disinvestment, these experiences of devaluation lead to sentiments of misrecognition and lack of representation on the political level.
description: Diese Doktorarbeit basiert auf der ethnografischen Feldforschung, die ich von September 2018 bis Oktober 2019 unter ehemaligen und aktuellen Automobilarbeitern in Zwickau durchgeführt habe. Die Dissertation behandelt verschiedene Themen im Zusammenhang mit industriellen und sozialen Transformationen in der Automobilindustrie in Ostdeutschland. Basierend auf meiner Feldarbeit und der Literatur zum Postsozialismus, zu industrieller Arbeit und zum Populismus sowohl innerhalb als auch außerhalb des Bereichs der Sozialanthropologie zeige ich auf, dass die Arbeiter verschiedene Formen der Entmachtung und Entwertung erfahren haben, darunter den Rückgang des sozialen Status, die Entwertung der sozialistischen Produktion und die ökonomische und symbolische Hegemonie des Westens. Zusammen mit der Schwächung der Arbeiterbewegungen, der Neoliberalisierung und der ungleichen Entwicklung führen diese Erfahrungen der Entwertung zu einem Gefühl der Missachtung und mangelnden politischen Vertretung.
Instantons on the six-sphere and twistors
Creators: name: Lechtenfeld, Olaf
name: Popov, Alexander D.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider the six-sphere S^6=G_2/SU(3) and its twistor space Z=G_2/U(2) associated with the SU(3)-structure on S^6. It is shown that a Hermitian Yang-Mills connection (instanton) on a smooth vector bundle over S^6 is equivalent to a flat partial connection on a vector bundle over the twistor space Z. The relation with Tian's tangent instantons on R^7 and their twistor description are briefly discussed.
description: 12 pages; v2: clarifying comments added, published version
title: Governments, Parliaments and Parties (France)
title: Governments, Parliaments and Parties (France)
Creators: name: Bock, Fabienne
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Frankreich
subject: Weltkrieg [1914-1918]
subject: Politik
subject: o.P. France--Politics and government--1914-1940
subject: World War, 1914-1918--France

description: Despite its weaknesses, the French parliamentary republic survived the First World War without compromising the constitutional laws that had been in place since 1875. The ''Union sacrée'' was formed on 4 August 1914. While this initially resulted in the Chambers letting the government run the country, by January 1915 they had reclaimed their power to control the executive and legislate by shifting most activity towards parliamentary commissions and secret committees. The breakup of the ''Union sacrée'' then led a majority of Parliament to throw its support behind the government formed by Georges Clemenceau in November 1917.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Developing biomarkers for mussel leukemia as tools for ecosystem health monitoring
Creators: name: Vassilenko, Ekaterina
Publisher: name: University of British Columbia
Year: 2012

description: The overall goal of this project was to develop biomarkers for mussel leukemia, a sublethal endpoint used in population health monitoring. The most common method for leukemia assessment is hematocytology, which is labour intensive and subject to bias. In this thesis, new biomarkers based on DNA ploidy detection and genotyping, were developed and compared with hematocytology. These new biomarkers would allow for more sensitive and efficient monitoring of near-shore ecosystems. Two Mytilus species, M. trossulus and M. edulis, were tested. Samples were obtained from Hopkins and Horseshoe Bay beaches, a mussel farm (Island Scallops, BC) and from caged mussels of the same origins submerged at a monitoring site in Burrard Inlet and a reference site off the Sunshine Coast. Three single nucleotide polymorphisms (SNPs) were detected within the coding region of p53 amplified from M. trossulus haemocyte cDNA, which were associated with leukemia. Many more polymorphic sites were found in M. edulis, some correlated with leukemia. Blocks in the p53 coding region sequences from late leukemic M. edulis were homologous with the M. trossulus p53 sequences, suggesting that hybridization may have contributed to increased disease susceptibility. Correlations between genotype and disease were not found in beach mussels or in either mussel species with early stages of leukemia. DNA content flow cytometry patterns for M. trossulus haemocytes could distinguish healthy animals from diseased for all stages of leukemia, including early ones, where haemolymph contains mixtures of healthy and neoplastic cells. No strong association was observed between ploidy and leukemia in M. edulis. This new method for M. trossulus leukemia detection is recommended for monitoring of marine ecosystems exposed to multiple stressors, for which leukemia is a valuable endpoint together with other biomarkers required for efficient environmental management.
A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam
Creators: name: Yu, Yi-Fan
name: Li, Yue-Qian
name: Wang, Ru-Yue
name: Liu, Xu
name: Cui, Wen-Bo
name: Chen, Xiao-Han
name: Zhao, Cheng-Mu
name: Qi, Feng-Ming
name: Zhang, Zhan-Xin
name: Fei, Dong-Qing
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: A new highly oxygenated germacranolide, carcerlane A (1), together with four known highly oxygenated germacranolides (2–5), was isolated from an ethanol extract of the whole plant of Carpesium nepalense var. lanatum (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectroscopic data including IR, 1 D and 2 D NMR spectra. To our best knowledge, it was the first time to report the phytochemical investigation on this plant. The anti-Alzheimer’s disease (AD) activities of 1–5 were evaluated using Caenorhabditis elegans AD pathological model. All the tested compounds showed that they have the anti-AD bioactivities of delaying worms paralysis.
Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways
Creators: name: Ivanov, Vladimir N.
name: Wu, Jinhua
name: Hei, Tom K.
Publisher: name: Columbia University
Year: 2017
Subjects: Glioblastoma multiforme
Cancer--Treatment
Apoptosis
Radiotherapy

description: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of GBM while protecting neurons and neural stem/progenitor cells in the brain. The goal of the present study was upregulation of the cytotoxic effect of γ-irradiation in GBM by non-psychotropic and non-toxic cannabinoid, cannabidiol (CBD). We emphasized three main aspects of signaling mechanisms induced by CBD treatment (alone or in combination with γ-irradiation) in human GBM that govern cell death: 1) CBD significantly upregulated the active (phosphorylated) JNK1/2 and MAPK p38 levels with the subsequent downregulation of the active phospho-ERK1/2 and phospho-AKT1 levels. MAPK p38 was one of the main drivers of CBD-induced cell death, while death levels after combined treatment of CBD and radiation were dependent on both MAPK p38 and JNK. Both MAPK p38 and JNK regulate the endogenous TRAIL expression. 2) NF-κB p65-P(Ser536) was not the main target of CBD treatment and this transcription factor was found at high levels in CBD-treated GBM cells. Additional suppression of p65-P(Ser536) levels using specific small molecule inhibitors significantly increased CBD-induced apoptosis. 3) CBD treatment substantially upregulated TNF/TNFR1 and TRAIL/TRAIL-R2 signaling by modulation of both ligand and receptor levels followed by apoptosis. Our results demonstrate that radiation-induced death in GBM could be enhanced by CBD-mediated signaling in concert with its marginal effects for neural stem/progenitor cells and astrocytes. It will allow selecting efficient targets for sensitization of GBM and overcoming cancer therapy-induced severe adverse sequelae.
The role of the GID complex at the primary cilium
Creators: name: Hantel, Friederike
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: The primary cilium acts as a signalling hub for many important pathways, including the Hedgehog signalling pathway (Hh). Sonic hedgehog (Shh) can be activated via the canonical signalling route, involving proteins of the GLI family, which localise to the primary cilium. A study by Boldt et al. located the mammalian homologue to the GID complex in close proximity to the primary cilium. The GID complex was first discovered in Saccharomyces cerevisiae. However, little is known about the mammalian GID complex and the roles it plays, especially regarding primary cilia. In summary, this thesis underscores the interplay between the primary cilia and the GID complex in mammalian cells. Additionally, four subunits of the GID complex were shown to localise to the primary cilia, further strengthening the hypothesis of an intricate relationship between these two players. Lastly, putative novel interacting partners for GID4 could be proposed.
description: Das primäre Cilium fungiert als Signalknotenpunkt für viele wichtige Signalwege, einschließlich des Hedgehog-Signalwegs (Hh). Sonic Hedgehog (Shh) kann über den kanonischen Signalweg aktiviert werden, an dem Proteine der GLI-Familie beteiligt sind, die im primären Zilium lokalisiert sind. Eine Studie von Boldt et al. lokalisierte das Säuger-Homolog zum GID-Komplex in unmittelbarer Nähe des primären Ziliums. Der GID-Komplex wurde zuerst in Saccharomyces cerevisiae entdeckt, über den Säugetier-GID-Komplex und die Rolle, die er spielt, ist wenig bekannt. Zusammenfassend unterstreicht diese Arbeit das Zusammenspiel zwischen den primären Zilien und dem GID-Komplex in Säugetierzellen. Darüber hinaus wurde gezeigt, dass sich vier Untereinheiten des GID-Komplexes an den primären Zilien lokalisieren, was die Hypothese einer komplizierten Beziehung zwischen diesen beiden Akteuren weiter stärkt. Schließlich konnten mutmaßliche neuartige Interaktionspartner für GID4 vorgeschlagen werden.
title: Willingly to War. Public Response to the Outbreak of War
title: Willingly to War. Public Response to the Outbreak of War
Creators: name: Becker, Jean-Jacques
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Weltkrieg [1914-1918]
subject: Öffentliche Meinung
subject: Kriegsausbruch
subject: o.P. World War, 1914-1918--Public opinion

description: It may surprise us to learn that some sectors of the European public were in favour of the war in 1914. The impact of modern weapons was not well understood and many people in the government, military and civilian population imagined that the conflict would be short. Ultimately the essential question regarding the First World War is not why did it happen – there have been innumerable studies written on this question - but rather what drove it on. Its main root was the strong patriotic and national feeling of the rural and urban middle classes of Central and Western Europe.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Messung der Wirksamkeit interaktiver Lehrmethoden : eine Evaluationsstudie
Creators: name: Köhler, Thomas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 300

description: Der Fokus der vorliegenden Dissertation liegt auf der Herausarbeitung einer Methodik zur Wirksamkeitsmessung verschiedenster, hier interaktiver, Lehrmethoden. Das herausgearbeitete Instrumentarium soll dabei möglichst breit anwendbar sein, unabhängig von einer konkreten Lehrmethode, den Fachinhalten und sonstigen Rahmnebedingungen. Dabei soll sich das Instrumentarium grundsätzlich dafür eignen, eine Längsschnittbetrachtung der Veränderungen der Zielgrößen bei Studierenden wie auch bei Dozierenden zu gewährleisten. Die Messungen basieren dabei auf den Selbsteinschätzungen der Studierenden hinsichtlich ihrer Fach-, Methoden- und Kommunikationskompetenz sowie ihrer Studierzufriedenheit und ihrem Commitment, das Studium weiterzuführen. Die Arbeit beschränkt sich hierbei auf die Evaluation mithilfe von deskriptiven Verfahren und dem Aufzeigen von Trends. Darüber hinaus werden Möglichkeiten diskutiert, das präsentierte Verfahren auch auf fortschrittlichere Zusammenhangsanalysen anzuwenden.
description: The main goal of this dissertation is on the elaboration of a methodology for measuring the effectiveness of various, in this case interactive, teaching approaches. The developed instruments should be applicable as broadly as possible, independent of a specific teaching method, the subject contents and other settings. Moreover, the instruments should be suitable to guarantee a longitudinal observation of the changes in the target values of students and teachers. The measurements are based on the students' self-assessments regarding their subject, methodological and communication competencies as well as their satisfaction with their studies and their commitment to continue their studies. The work is limited to the evaluation with the help of descriptive methods and the identification of trends in the data. Furthermore, possibilities are shown to apply the presented procedure to more advanced contextual analyses.
title: So schmeckt der Krieg, oder: „Ich muss mich gleich übergeben.“
Creators: name: Grassl, Philomena
Publisher: name: Fachinformationsdienst Slavistik
Year: 2013
Subjects: subject: Melaschwili, Tamta Abzählen
subject: Georgisch
subject: Russisch
subject: Übersetzung
subject: Rezension
subject: 491.8

description: Georgien war eines der ersten Länder, die nach dem Zerfall der Sowjetunion unabhängig wurden, seither wurde es immer wieder zum Schauplatz geopolitischen Kräftemessens. Bei dem Krieg im August 2008 drangen russische Truppen bis ins georgische Kernland ein. Darüber wurde in den Medien viel berichtet, allerdings nicht davon, wie so ein Krieg von den Menschen dort erlebt wird. Die junge georgische Autorin Tamta Melaschwili zeigt uns mit ihrem Debütroman Abzählen diesen anderen Krieg.
description: novinkigegengelesen
title: Graves, Robert
title: Graves, Robert
Creators: name: Brearton, Fran
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Graves, Robert
subject: Graves, Robert, 1895-1985

description: Robert Graves was a British writer who enlisted in August 1914. He fought at the Battle of Loos in 1915, and was wounded at the Somme in 1916. He published his first volumes of poems during the war, and his bestselling war memoir, ''Goodbye to All That'', in 1929.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
title: Between Acceptance and Refusal - Soldiers' Attitudes Towards War (Indochina)
title: Between Acceptance and Refusal - Soldiers' Attitudes Towards War (Indochina)
Creators: name: Vu-Hill, Kimloan
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Indochina
subject: Weltkrieg [1914-1918]
subject: Soldat
subject: o.P. World War, 1914-1918
subject: Indochina
subject: Soldiers

description: This paper provides a brief account of the experiences of the Vietnamese who went to Europe as soldiers during World War I. It shows that, contrary to a common belief among many historians that they were conscripted laborers, most were volunteers. Their experiences in the war changed their perceptions about the established order and the standing of French colonialism in Indochina. It eventually led to resistance to the French domination of the country. The paper concludes that World War I was the beginning of the end of the French colonial enterprise in Vietnam.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Computational analysis of single nucleotide polymorphisms (SNPs) in PPAR gamma associated with obesity, diabetes and cancer
Creators: name: Stalin, Antony
name: Lin, Ding
name: Princy, Johnson Josephine
name: Feng, Yue
name: Xiang, Haiping
name: Ignacimuthu, Savarimuthu
name: Chen, Yuan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: The single nucleotide polymorphisms (SNPs) are the common genetic variations in human genomes and act as markers for molecular susceptibility of complex traits and diseases in humans. Amino acid variations in the non-synonymous SNPs (nsSNPs) in coding and non-coding regions affect the function/structure of the proteins. The Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a nuclear receptor that plays a significant role in lipid metabolism and insulin production and is associated with diabetes, obesity, and cancer. In this study, the PPARG sequence was retrieved from the NCBI database (dbSNP: NP_619726.2), and an analysis was done to predict the damaged/harmful mutated amino acids. We identified five mutated variants (C162S, R166W, Q286P, or Q314P and P467L), which were mostly expressed in cancer tissues and associated with insulin resistance and partial lipodystrophy. The identified mutations were induced, and the analysis of molecular dynamics simulation was established to determine the dynamic stability/flexibility of PPARG. The dynamic trajectories were analyzed by RMSD, RMSF, and Radius of Gyration (Rg) analysis; a vast difference was noticed in each of the protein structure when compared with the PPARG wild-type, and the mutations in PPARG impaired its functions, leading to more significant problems in humans. Communicated by Ramaswamy H. Sarma HighlightsPPARG plays a significant role in diseases like diabetes, obesity, and cancer.Five mutated variants are expressed in cancer, insulin resistance and partial lipodystrophy.MD simulation was carried out to identify the dynamic stability/flexibility of PPARG.The colossal differences are identified in the dynamics process.Mutations in PPARG impair its functions, leading to significant problems in humans. PPARG plays a significant role in diseases like diabetes, obesity, and cancer. Five mutated variants are expressed in cancer, insulin resistance and partial lipodystrophy. MD simulation was carried out to identify the dynamic stability/flexibility of PPARG. The colossal differences are identified in the dynamics process. Mutations in PPARG impair its functions, leading to significant problems in humans.
title: Carrier Corps
title: Carrier Corps
Creators: name: Murphy, Mahon
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: Großbritannien
subject: Transportarbeiter
subject: Weltkrieg [1914-1918]
subject: o.P. Ostafrika
subject: o.P. World War, 1914-1918--Regimental histories--Great Britain
subject: World War, 1914-1918--Campaigns--Africa, East

description: The Carrier Corps were a conscripted labour force used by all belligerent sides in the First World War in East Africa. The numbers recruited and the subsequent displacement of populations was one of the biggest effects of the war in East Africa.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
title: Tanga, Battle of
title: Tanga, Battle of
Creators: name: Murphy, Mahon
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: Deutsch-Ostafrika
subject: Weltkrieg [1914-1918]
subject: Tanga, Battle of, Tanga, Tanzania, 1914

description: The Battle of Tanga was the first major military engagement in East Africa and a significant British set back. It also contributed to the creation of Paul von Lettow-Vorbeck’s legend.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
The Role of SoTL in Classroom Innovation
Creators: name: Tierney, Anne Margaret
Publisher: name: Edge Hill University
Year: 2021
Subjects: subject: Education
subject: 130103 Higher Education
subject: FOS: Educational sciences

description: The Scholarship of Teaching and Learning (SoTL) is being promoted as an activity for teaching-focused academics in the UK. However, support for SoTL is not a priority for most institutions, and formal provision for such support may not extend beyond the postgraduate certificate in higher education that is offered for new academic staff.
This paper examines the experiences of SoTL of a group of twenty-one Life Sciences academics from a range of UK universities. It explores the role that SoTL has to play in developing classroom innovation in a structured and scholarly manner, and the consequences to both teaching staff and students, if SoTL is not supported as an academic activity throughout the careers of teaching-focused academics.
This paper was presented at the 40th Improving University Teaching international conference, Faculty of Law, University of Ljubljana, Slovenia.
Dressing approach to the nonvanishing boundary value problem for the AKNS hierarchy
Creators: name: Gomes, J. F.
name: França, Guilherme S.
name: Zimerman, A. H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 70H06, 34B15

description: We propose an approach to the nonvanishing boundary value problem for integrable hierarchies based on the dressing method. Then we apply the method to the AKNS hierarchy. The solutions are found by introducing appropriate vertex operators that takes into account the boundary conditions.
description: Published version Proc. Quantum Theory and Symmetries 7 (QTS7)(Prague, Czech Republic, 2011)
Observation of eta_b(2S) in Upsilon(2S) -> gamma eta_b(2S), eta_b(2S) -> hadrons, and Confirmation of eta_b(1S)
Creators: name: Dobbs, S.
name: Metreveli, Z.
name: Seth, Kamal K.
name: Tomaradze, A.
name: Xiao, T.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The data for 9.3 million Upsilon(2S) and 20.9 million Upsilon(1S) taken with the CLEO III detector has been used to study the radiative population of states identified by their decay into twenty six different exclusive hadronic final states. In the Upsilon(2S) decays an enhancement is observed at a ~5 sigma level at a mass of 9974.6+-2.3(stat)+-2.1(syst) MeV. It is attributed to eta_b(2S), and corresponds to the Upsilon(2S) hyperfine splitting of 48.7+-2.3(stat)+-2.1(syst) MeV. In the Upsilon(1S) decays, the identification of eta_b(1S) is confirmed at a ~3 sigma level with M(eta_b(1S)) in agreement with its known value.
description: 5 pages, 2 figures
Experiences in a Culturally Responsive Student Affairs: An Indigenization Journey
Creators: name: Ngwudike, Ifeoma
name: Alcock, Arlayna
Publisher: name: CACUSS
Year: 2019
Subjects: Student affairs services
Emotional and interpersonal intelligence
Leadership
Indigenous cultural awareness

description: We have heard discussions about indigenization and decolonization in our educational institutions with a lot of work being done on implementing the calls to action from the Truth and Reconciliation Committee. What exactly is indigenization and how do I apply it in my work with students? In this article, we will share some of the small and practical ways we are incorporating the holistic ways of being from indigenous philosophy to our student development/leadership and transition programming.
Untersuchung der Expression und phänotypischen Bedeutung von Ran-binding protein 3-like in innermedullären Sammelrohrzellen der Niere
Creators: name: Chernyakov, Dmitry
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 572

description: In der Niere herrscht ein osmotischer Gradient zwischen Cortex und Medulla. Die Zellen aktivieren gezielte Adaptionsmechanismen, durch Aktivierung spezifischer Targets, welche über NFAT5 reguliert sind. Eines der dabei am stärksten regulierten Gene ist das RANBP3L. Innerhalb dieser Arbeit konnte in murinen NFAT5 Knockout-Systemen gezeigt werden, dass die Expressionsinduktion von Ranbp3l verloren geht. Anschließend wurde RANBP3L ausgeknockt und in Zelllinien charakterisiert. Die Ergebnisse zeigten eine onkogene Wirkung des RANBP3L-Verlustes und ein starkes Nierenzellkarzinom-abhängiges Expressionsprofil. Vor allem fiel eine Anreichung von Sparc auf. Durch eine weitere SPARC-Depletion konnte der onkogene Phänotyp abgemildert werden. Arbeiten zeigten eine Rolle von SPARC im Nierenzellkarzinom. Hier zeigen unsere Daten, dass eine RANBP3L-Überexpression die Expression von Sparc hemmt. Da bereits c-JUN als Transkriptionsfaktor für SPARC bekannt ist, wäre dies ein therapeutischer Ansatz.
description: In the kidney, there is an osmotic gradient between the cortex and medulla. The cells activate specific adaptive mechanisms by activating specific targets regulated by NFAT5. One of the most regulated genes is RANBP3L. Within this work, murine NFAT5 knockout systems were shown to lose expression induction of Ranbp3l. Subsequently, RANBP3L was knocked out and characterized in cell lines. The results showed an oncogenic effect of RANBP3L loss and a strong renal cell carcinoma-dependent expression profile. Most notably, there was an enrichment of Sparc. Further SPARC depletion attenuated the oncogenic phenotype. Other work demonstrated a role for SPARC in renal cell carcinoma. Here, our data show that RANBP3L overexpression inhibits the expression of Sparc. Since c-JUN is already known to be a transcription factor for SPARC, this would be a therapeutic approach.
title: Russell, Bertrand
title: Russell, Bertrand
Creators: name: Miller, Alisa
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Russell, Bertrand
subject: o.P. Russell, Bertrand, 1872-1970

description: This article examines how the outbreak of war in 1914 established Bertrand Russell’s reputation as social critic with an international audience. It considers his major writings on a range of topics, from foreign policy to the psychological impulses that make war possible, and his work on behalf of conscientious objectors.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
CybSPEED MSCA-RISE #777720: vision and perspectives
Creators: name: Graña, Manuel
Publisher: name: Zenodo
Year: 2019

description: Presentation given at the:

International Symposium for “Potentials and Perspectives of Communication among Humans and Agents Including Robots and Animals”

Organized by Prof. Hiroaki Wagatsuma at the Conference Center, Kitakyushu Foundation for the Advancement of Industry, Science and Technology.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 777720
Synthese und Biokompatibilitätsbewertungen neuartiger, biofunktioneller Polymere für die Medizintechnik
Creators: name: Borgolte, Max
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Infektionen von Implantaten, insbesondere mit multiresistenten Erregern, wie beispielsweise MRSA, stellen eine enorme Problematik in der Implantationsmedizin dar. In der vorliegenden Arbeit wurden neuartige, biofunktionelle Polymere basierend auf Chitosan sowie Glucosamin für eine Oberflächenfunktionalisierung untersucht. Hierzu wurden diverse N-Acetylglucosamin-Methacrylate mit Dimethacrylamid und einem Benzophenon-Methacrylat als UV-Quervernetzer copolymerisiert. Außerdem wurde Chitosan selbst mit einer Benzophenoneinheit modifiziert. Diese Polymere wurden als biofunktionelle Beschichtungen auf medizinisch relevanten Modellmaterialien evaluiert, chemisch-physikalisch charakterisiert und deren antibakterielle Wirksamkeit untersucht. Hiermit wurde eine signifikante Reduktion der bakteriellen Kontamination bei gleichzeitig guter Biokompatibilität erzielt. Die Biokompatibilitätsuntersuchungen wurden auf einen fluoreszenzbasierten Schnelltest auf L-Kynurenin als Biomarker für inflammatorische Prozesse sowie Abstoßungsreaktionen ausgedehnt.
description: Infections of implants, especially with multi-resistant pathogens such as MRSA, represent an enormous problem in implant medicine. In the present study, novel biofunctional polymers, based on chitosan and glucosamine, were investigated for surface functionalisation of medical implant materials. For this purpose, various N-acetylglucosamine methacrylates were copolymerised with dimethacrylamide and a benzophenone methacrylate as UV-responsive crosslinker. In addition, chitosan itself was modified with a benzophenone moiety. These polymers were evaluated as biofunctional coatings on medical relevant model materials, characterised chemically and physically and their antibacterial efficacy was investigated. Hereby, a significant reduction of bacterial contamination on the material surface was achieved while maintaining good biocompatibility. The biocompatibility tests were extended to include a fluorescence-based rapid test for L-kynurenine as a biomarker for inflammatory processes and implant rejection.
Intuitionistic implication makes model checking hard
Creators: name: Mundhenk, Martin
name: Weiss, Felix
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computational Complexity (cs.CC)
subject: FOS: Computer and information sciences
subject: 03B20, 68Q15, 68Q17

description: We investigate the complexity of the model checking problem for intuitionistic and modal propositional logics over transitive Kripke models. More specific, we consider intuitionistic logic IPC, basic propositional logic BPL, formal propositional logic FPL, and Jankov's logic KC. We show that the model checking problem is P-complete for the implicational fragments of all these intuitionistic logics. For BPL and FPL we reach P-hardness even on the implicational fragment with only one variable. The same hardness results are obtained for the strictly implicational fragments of their modal companions. Moreover, we investigate whether formulas with less variables and additional connectives make model checking easier. Whereas for variable free formulas outside of the implicational fragment, FPL model checking is shown to be in LOGCFL, the problem remains P-complete for BPL.
description: 29 pages, 10 figures
Risk Aversion as a Perceptual Bias
Creators: name: Khaw, Mel Win
name: Li, Ziang
name: Woodford, Michael
Publisher: name: Columbia University
Year: 2017
Subjects: Economics--Decision making
Risk

description: The theory of expected utility maximization (EUM) explains risk aversion as due to diminishing marginal utility of wealth. However, observed choices between risky lotteries are difficult to reconcile with EUM: for example, in the laboratory, subjects' responses on individual trials involve a random element, and cannot be predicted purely from the terms offered; and subjects often appear to be too risk averse with regard to small gambles (while still accepting sufficiently favorable large gambles) to be consistent with any utility-of-wealth function. We propose a unified explanation for both anomalies, similar to the explanation given for related phenomena in the case of perceptual judgments: they result from judgments based on imprecise (and noisy) mental representation of the decision situation. In this model, risk aversion is predicted without any need for a nonlinear utility-of-wealth function, and instead results from a sort of perceptual bias — but one that represents an optimal Bayesian decision, given the limitations of the mental representation of the situation. We propose a specific quantitative model of the mental representation of a simple lottery choice problem, based on other evidence regarding numerical cognition, and test its ability to explain the choice frequencies that we observe in a laboratory experiment.
title: Ojetti, Ugo
title: Ojetti, Ugo
Creators: name: Daly, Selena
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Ojetti, Ugo
subject: o.P. Ojetti, Ugo, 1871-1946

description: Ugo Ojetti was a journalist who, during the war, was tasked with the protection of monuments and artworks in the Italian-occupied territories. He was also instrumental in establishing and managing Italy’s wartime propaganda regime.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Die Mundgesundheitssituation 12-jähriger Schulkinder in der ländlichen Region Ilembula im Südwesten Tansanias
Creators: name: Zumpe, Lisa
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Erkrankungen der Mundhöhle zählen zu den häufigsten chronischen nichtübertragbaren Krankheiten weltweit. Trotz bereits bestehender hoher Zahlen geht die WHO für sogenannte Entwicklungsländer von einer zunehmenden Inzidenz aus. Für den Südwesten Tansanias sind diesbezüglich jedoch nur unzureichend Daten vorhanden. Die Zielstellung der vorliegenden Arbeit ist daher die Erfassung der aktuellen Mundgesundheitssituation von Schulkindern in der ländlichen Region Ilembula im Südwesten Tansanias. 2020 wurde dort an zwei Grundschulen eine non-invasive Querschnittsstudie mit 319 Proband*innen im Alter von 11 bis 12 Jahren durchgeführt. Es konnte ein durchschnittlicher DMFT von 0,24 (± 0,68) sowie eine Kariesprävalenz von 14,7% ermittelt werden. Die Ergebnisse der vorliegenden Studie legen nahe, dass entgegen den Prognosen der WHO die Prävalenz von Karies in Ilembula innerhalb der letzten Jahrzehnte nicht angestiegen ist und der DMFT weiterhin zu dem Niedrigsten bei 12-Jährigen weltweit zählt.
description: Oral diseases are among the most common chronic non-communicable diseases worldwide. Despite already existing high numbers, the WHO assumes an increasing incidence for so-called developing countries. However, insufficient data is available for the southwest of Tanzania. The objective of this study is therefore to assess the current oral health situation of school children in the rural region of Ilembula in southwestern Tanzania. In 2020, a non-invasive cross-sectional study with 319 subjects aged 11 to 12 years was conducted at two primary schools. A mean DMFT of 0.24 (± 0.68) and a caries prevalence of 14.7% were found. The results of this study suggest that contrary to WHO predictions, the prevalence of caries in Ilembula has not increased over the past decades and the DMFT remains among the lowest in the world for 12-year-olds.
Putting Green Infrastructure on Private Property in New York City
Creators: name: Gundlach, Justin M.
Publisher: name: Columbia University
Year: 2017
Subjects: Urban runoff--Management
Infrastructure (Economics)--Government policy
Water harvesting
Green technology--Government policy
Property

description: New York's Department of Environmental Protection is under pressure to install large amounts of green infrastructure in order to take pressure off of the city's combined sewer system, which currently discharges raw sewage into adjacent water bodies during periods of moderate to severe precipitation. Installing enough green infrastructure to make a difference to that end (and others) means encouraging a large number of private property owners to install rain gardens and green roofs. Efforts to do that to date have fallen short. This paper discusses the city's goals for green infrastructure (and reasons for wanting it), the challenges facing efforts to spend public money on assets installed on private property, and possible sources of solutions.
Social Entrepreneurship and Event Management
Creators: name: Tierney, Anne Margaret
Publisher: name: Edge Hill University
Year: 2021
Subjects: subject: Education
subject: 130103 Higher Education
subject: FOS: Educational sciences

description: Final year undergraduates in the School of Life Sciences at the University of Glasgow may take a two week, intensive course called Business & Bioscience. Student teams work together on the development of innovative bioscience products.
After the two week course, the students are required to plan and organise events which will be of benefit to students and the local community. Since 2008 there have been more than twelve events, ranging from “Safety on Campus” to “Style That’s Worthwhile”. This paper will examine the development of the events and the transition from student events to local community events.
This paper was presented at the 37th Improving University Teaching International Conference, University of Innsbruck, July 24-27th.
Bone metastasis target redox-responsive micell for the treatment of lung cancer bone metastasis and anti-bone resorption
Creators: name: Ye, Wei-Liang
name: Zhao, Yi-Pu
name: Cheng, Ying
name: Liu, Dao-Zhou
name: Cui, Han
name: Liu, Miao
name: Zhang, Bang-Le
name: Mei, Qi-Bing
name: Zhou, Si-Yuan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology

description: In order to inhibit the growth of lung cancer bone metastasis and reduce the bone resorption at bone metastasis sites, a bone metastasis target micelle DOX@DBMs-ALN was prepared. The size and the zeta potential of DOX@DBNs-ALN were about 60 nm and −15 mV, respectively. DOX@DBMs-ALN exhibited high binding affinity with hydroxyapatite and released DOX in redox-responsive manner. DOX@DBMs-ALN was effectively up taken by A549 cells and delivered DOX to the nucleus of A549 cells, which resulted in strong cytotoxicity on A549 cells. The in vivo experimental results indicated that DOX@DBMs-ALN specifically delivered DOX to bone metastasis site and obviously prolonged the retention time of DOX in bone metastasis site. Moreover, DOX@DBMs-ALN not only significantly inhibited the growth of bone metastasis tumour but also obviously reduced the bone resorption at bone metastasis sites without causing marked systemic toxicity. Thus, DOX@DBMs-ALN has great potential in the treatment of lung cancer bone metastasis.
Structural domain and spin ordering induced glassy magnetic phase in single layered manganite Pr$_{0.22}$Sr$_{1.78}$MnO$_4$
Creators: name: Chattopadhyay, S.
name: Giri, S.
name: Majumdar, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The single layered manganite Pr$_{0.22}$Sr$_{1.78}$MnO$_4$ undergoes structural transition from high temperature tetragonal phase to low temperature orthorhombic phase below room temperature. The orthorhombic phase was reported to have two structural variants with slightly different lattice parameters and Mn-3$d$ levels show orbital ordering within both the variants, albeit having mutually perpendicular ordering axis. In addition to orbital ordering, the orthorhombic variants also order antiferromagnetically with different Néel temperatures. Our magnetic investigation on the polycrystalline sample of Pr$_{0.22}$Sr$_{1.78}$MnO$_4$ shows large thermal hysteresis indicating the first order nature of the tetragonal to orthorhombic transition. We observe magnetic memory, large relaxation, frequency dependent ac susceptbility and aging effects at low temperature, which indicate spin glass like magnetic ground state in the sample. The glassy magnetic state presumably arises from the interfacial frustration of orthorhombic domains with orbital and spin orderings playing crucial role toward the competing magnetic interactions.
description: 6 pages, 4 figures, Accepted in Europhysics Letters
Effekt von Basalinsulin-Inkretinmimetischer Therapie bei Typ-2-Diabetikern nach Myokardrevaskularisation auf die Hypoglykämierate
Creators: name: Golle, Linda
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Der Einsatz inkretinmimetischer Therapie bei Typ 2 Diabetes mellitus kann zu einem reduzierten Insulinbedarf mit weniger Hypoglykämien und Reduktion der kardialen Mortailtät führen. Ziel des Studienvorhabens ist es, die Auswirkung Basalinsulin-Inkretinmimetischer Therapie im Vergleich zu insulingeführter bzw. im Vergleich zu oral antidiabetischer Therapie auf das Auftreten von Hypoglykämien, das Überleben, Rehospitalisierungsraten, den HbA1c sowie den Body Mass Index bei operativ oder interventionell myokardrevaskularisierten Patienten mit kardiovaskulärem Höchstrisiko, retro- und prospektiv in einem „real-world“ Patientenkollektiv zu untersuchen. Die Daten der vorliegenden Studie weisen auf einen überraschend niedrigen Gebrauch von inkretinmimetischer Therapie hin, welcher durch die Studienlage nicht erklärbar ist. Ferner bestätigte sich im Nachbeobachtungszeitraum eine erhöhte Inzidenz von symptomatischen Hypoglykämien bei insulingeführten versus OAD-geführten Typ-2-Diabetikern.
description: The use of incretin mimetic therapy in type 2 diabetes mellitus can lead to reduced insulin requirement with less hypoglycaemia and a reduction in cardiac mortality. The aim of the study project is to determine the effect of basal insulin-incretin mimetic therapy compared to insulin-controlled or compared to oral antidiabetic therapy on the occurrence of hypoglycaemia, survival, rehospitalization rates, HbA1c and body mass index in surgically or interventionally myocardial revascularized patients with highest cardiovascular risk to examine retrospectively and prospectively in a "real-world" patient group. The data of the present study indicate a surprisingly low use of incretin mimetic therapy, which cannot be explained by the study situation. Furthermore, an increased incidence of symptomatic hypoglycaemia in insulin-controlled versus OAD-controlled type 2 diabetics was confirmed in the follow-up period.
Understanding the action of gas hydrate kinetic inhibitors
Creators: name: Daraboina, Nagu
Publisher: name: University of British Columbia
Year: 2012

description: The presence of inhibitors delayed hydrate nucleation and decreased the overall formation of methane/ethane/propane hydrate compared to pure water system. However, the two classes of inhibitors: chemical (Polyvinylpyrrolidone (PVP) and industrial inhibitor: H1W85281) and a biological (Type I and III antifreeze protein (AFP)) were distinguished by the formation of hydrates with different stabilities. A single hydrate-melting peak was seen with the AFP-III and this was consistent after re-crystallization. In contrast, multiple hydrate melting events were observed in the presence of the chemical inhibitors. In stirred reactor, onset of hydrate decomposition occurred earlier in the presence of the inhibitors compared to water controls. However, depending on the type of inhibitor present during crystallization, hydrate decomposition profiles were distinct, with a longer, two-stage decomposition profile in the presence of the chemical inhibitors. The fastest, single-stage decompositions were characteristic of hydrates in experiments with either of the AFPs. Powder X-ray diffraction and nuclear magnetic resonance spectroscopy showed that structure II hydrates dominated, as expected, but in the presence of the chemical inhibitors structure I was also present. Raman spectroscopy confirmed the complexity and the heterogeneity of the guest composition within these hydrates. However, in the presence of AFP-III, hydrates appeared to be relatively homogeneous structure II hydrates, with weaker evidence of structure I. When individual gas cage occupancies were calculated, in contrast to the near full occupancy of large cages with these inhibitors, almost 10% of the large cages were not filled when hydrates were formed in the presence of AFP-III, likely contributing to the easy decomposition of such hydrates seen in DSC and stirred reactor experiments. These results argue that thought must be given to inhibitor-mediated decomposition kinetics when designing and screening of new kinetic inhibitors. This is a necessary practical consideration for industry in cases when due to long shut in periods; hydrate formation may be unavoidable even when inhibitors are utilized. This heterogeneity suggests that using these chemical inhibitors (PVP and H1W85281) may present a special challenge to operators depending upon the gas mixture and environmental conditions, and that AFPs may offer a more predictable, efficacious solution in these cases.
Guidelines for Cryptographic Key Management
Creators: name: Bellovin, Steven Michael
name: Housley, Russell
Publisher: name: Columbia University
Year: 2005
Subjects: Computer science

description: The question often arises of whether a given security system requires some form of automated key management, or whether manual keying is sufficient. This memo provides guidelines for making such decisions. When symmetric cryptographic mechanisms are used in a protocol, the presumption is that automated key management is generally but not always needed. If manual keying is proposed, the burden of proving that automated key management is not required falls to the proposer.