cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SAFIR, analogy-based system for database definition and query reuse.
Creators: name: Ould-Brahim, Hamid.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Computer Science.

description: This thesis presents a system which employs analogical reasoning to define and manipulate databases. The objective is to model the behavior of naive users who often adapt database relations and queries from documentation examples to the problem at hand. The user has at her disposal a manual that contains examples of database designs with a variety of database queries in some exemplary milieu called the base domain. The manual explains the example queries in simple terms and gives their implementation in a database query language such as SQL. Our user is not a database expert. She can neither define the database nor can she compose query implementations from scratch. At best she can construct simple queries in the base domain by copying them verbatim from the manual. Our system works in two steps: first it defines a target database by building incrementally analogies represented by pairs of object correspondences, base-target. These analogies are built by mapping objects, relationships, and semantic constructs from the base domain into the target domain. The process is then interactive and incremental (i.e. the user can accept or reject the inferred analogies). The second step of the approach consists to derive target domain query's implementation from its specification by reusing queries developed in the base domain. We rely on a weak form of derivational analogy--traces of a planner operating in the base domain are used to derive a target domain query's implementation in SQL from its specification. The very simple planner used builds in the base domain plans that result in particularly simple, prototypical queries. Queries are specified in a high level subset of natural language.
title: Außenhandel, Klimawandel  und Klimaschutz
title: Wie internationale Arbeitsteilung und Handelspolitik  die weltweiten Treibhausgasemissionen reduzieren  können
titleType: Subtitle
Creators: name: Petersen, Thieß
Publisher: name: Bertelsmann Stiftung
publisherIdentifier: https://ror.org/01wj9hk44
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Internationaler Handel
Klimapolitik
Treibhausgase
Emissionen
Wirtschaftspolitik
Klimaschutz

description: Im Rahmen der internationalen Arbeitsteilung spezialisieren sich Länder auf die Herstellung bestimmter Produkte, die sie anschließend austauschen. Das hat sowohl emissionserhöhende als auch emissionssenkende Wirkungen, wobei gegenwärtig die emissionserhöhenden Effekte überwiegen. Warum das so ist und wie ein besseres Zusammenspiel von Klimaschutz- und Handelspolitik die internationale Arbeitsteilung zukünftig nachhaltiger ausgestalten kann, zeigt unser aktuelles Focus Paper.
The long-term effectiveness of dialysis, kidney transplantation and pancreas transplantation for patients with diabetes mellitus and renal failure: A decision analysis.
Creators: name: Knoll, Gregory Allan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Health Sciences, Public Health.

description: Background. Diabetics with renal failure have several treatment options including cadaveric (CKT) or living (LKT) kidney transplantation, simultaneous pancreas-kidney transplantation (SPKT), pancreas transplantation after kidney transplantation (PAKT) or dialysis. The objective was to determine the most effective treatment strategy. Methods. Decision analysis comparing dialysis, CKT, LKT, PAKT and SPKT. Model probabilities were obtained from the medical literature and utilities were obtained using the standard gamble. The outcome measure was quality-adjusted life expectancy (quality-adjusted life years, QALYs). Results. LKT was associated with 10.29 QALYs; PAKT, 10.00 QALYs; SPKT, 9.09 QALYs; CKT, 6.53 QALYs; dialysis, 4.52 QALYs. The results were sensitive to several key variables. Conclusion. LKT is the most effective treatment strategy for diabetics with renal failure. However, PAKT is preferred for patients with severe metabolic complications of diabetes and for those patients who favor the kidney-pancreas health state over kidney transplantation alone.
Using Git and GitHub in Software Engineering
Creators: name: Davitaia, Alexandre
Publisher: name: Zenodo
Year: 2025

description: This paper examines the crucial roles that Git and GitHub play in contemporary software engineering, emphasizing how they affect project management, collaborative development, and version control. Based on the author's own experience using GitHub Pages to create a static website, it illustrates how branching, pull requests, and GitHub Actions promote effective and superior software development. The article makes the case that Agile is the best development approach for integrating GitHub because of its emphasis on collaboration, iterative nature, and automation through CI/CD methods. In the end, Git and GitHub are portrayed as crucial resources that assist with the organizational and technological requirements of software engineering in both solo and collaborative settings.
Exploring the Relationship between School Gardens, Food Literacy and Mental Well-Being in Youth Using Photovoice
Creators: name: Lam, Vanessa
name: Romses, Kathy
name: Renwick, Kerry
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The goal of the project was to gain an understanding of the relationships between secondary school youth experiences in school gardens and their mental well-being. Over the course of five months, sixteen youths participated in a photovoice research project in which they expressed their personal experiences about food and gardening through photography and writing. The aspects of secondary school youths’ life experiences affected by exposure to school gardens and their impact upon their well-being were identified. The youth explicitly associated relaxation with the themes of love and connectedness, growing food, garden as a place, cooking, and food choices. They were able to demonstrate and develop food literacy competency because of their engagement with the gardening and cooking activities. Youth clubs or groups were identified as a key enabler for connection with other youth and adults. Youth shared their food literacy experiences, observing that their engagement improved some aspect of their mental well-being. Through the photovoice process, the youth identified how their involvement in green spaces enabled connections with others, and highlighted aspects of personal health and personal growth, all of which contribute to their mental well-being.
Computational fluid dynamics (CFD) of vehicle aerodynamics and associated acoustics
Creators: name: Murad, Nurul M.
Publisher: name: Swinburne
Year: 2024

description: Vortex generation behind the A-pillar region due to airflow separation leads to aero-acoustics generation. The magnitude and intensity of the vortex and hence aero-acoustics activities are further enhanced when vehicle are exposed to crosswind especially when travelling on a highway. The objective of this project is to develop a computational fluid dynamic (CFD) and computational aero-acoustics (CAA) model to best simulate aerodynamic flow and aero-acoustics propagation behind the A-pillar region of simplified vehicle with varying windshield radii under various yaw conditions. The CFD model will then be used to investigate and better understand the aerodynamic and aero-acoustics distribution behaviour surrounding area of the vehicle A-pillar region. The simplified vehicle model used was of 40% scale. Models investigated consist of three models of different circular windshield/A-pillar radii and two models of with sharp A-pillar edges with different windshield slant angle. Models used in this project were subjected to 0°, 5°, 10° and 15° yaw angles. The models were modelled under laboratory conditions, exposed to boundary inlet velocities of 60, 100 and 140 km/h.
LIBER Digital Skills Working Group: Case Studies on Open Science Skilling and Training Initiatives in Europe
Creators: name: Swiatek, Cecile
Publisher: name: Forschungzentrum Jülich
Year: 2019
Subjects: Digital Skills, Open Science, research libraries, training, upskilling

description: doi:10.5281/ZENODO.3901485
description: Open Science skills for both research librarians and researchers are at the center of all evolutions towards “openness”. The Digital Skills for Library staff and Researchers LIBER Working Group conducted a selection process in 2018 in order to identify Open Science training programmes relying on skills identification. In April 2019, questionnaires were sent to contacts in 28 countries, and complementary interviews were conducted for the production of country-specific case studies on Open Science skilling and training initiatives in Europe. The first results of this combined approach have been presented at LIBER's 2019 Annual Conference, in a workshop entitled  Open Science Essentials: Towards a Skill Set and Showcases at LIBER 2019 . The creation of case studies resulted in a publication of a full analysis in 2020: LIBER Open Science Training Methods and Practices Across European Research Libraries - Survey Analysis. Please, find the analysis here:  https://doi.org/10.5281/zenodo.3903141 . The objective of this activity is to offer the research library community inspiring methods, practices, contacts and words of wisdom, covering institutional cases, national initiatives as well as European project approaches. Overall, LIBER's Digital Skills Working Group aims to spread a more open culture and to position libraries as key-partners in skills training for the complex and forward-thinking concept of Open Science. This project displays the richness and diversity of European approaches towards Open Science skilling and training in both libraries and researchers’ communities, from mature programmes to emerging initiatives.
Establishment and characterization of P19 embryonal carcinoma cells harboring an inducible Sty gene.
Creators: name: Choi, Kyung Bok.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Molecular.

description: In order to establish Myc-Sty inducible clones, I generated a bio-cistronic Lac repressor expression construct (PCJ2LacIN) and subsequently transfected it along with pPOP $\beta$-gal into P19 EC cells. One of the clones (CJ2-8) showed 35 fold induction in $\beta$-gal activity between un-induced and induced cells. Subsequently, I also generated an inducible Sty expression vector (pPOPMycSty) containing two Lac operator sequences which is to be bound by Lac repressor to regulate the expression of the target genes at the downstream of the operator sequences. Following the co-transfection of pPOPMycSty, a construct containing PGK-1 promoter and its intragenic region, B17 and PGKNeo and subsequent drug selection, most of the drug resistant colonies turned out to be positive for Myc-Sty although its expression level and inducibility were somewhat variable among the clones. Myc-Sty from the inducible clone #9 is catalytically active, can dimerize with GST-Sty in vitro, phosphorylated on Tyr in vivo, localized in the nucleus and furthermore, immunofluorescence result showed that it phosphorylates and redistribute SR proteins in the nucleus resulting in affecting alternative splicing. Western analysis result using $\alpha$-SR monoclonal antibody (mAb104) recognizing the phospho-epitope common to every SR protein suggested that Sty may selectively phosphorylate SRp30 and SRp55, which were among the proteins found to be interacting with Sty by yeast two hybrid system. Subsequently, double immunofluorescence both for Myc-Sty and EC cell surface antigen (SSEA-1) or neuronal differentiation markers (A60 and HNK-1) indicated that Myc-Sty alone does not seem to give rise to the differentiation process.
El Auto de la destrucción de Jerusalén y el Nican motecpana in inemiliztzin : recepción literaria y teatro doctrinal de la Nueva España.
Creators: name: Salazar Quintana, Luis Carlos.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Literature, Latin American.

description: The purpose of this thesis is to analyze two works of the doctrinal theater of New Spain: the Auto de la destruccion de Jerusalen and the Nican motecpana in inemiliztzin , from the perspective of modern reception theory. This study is divided into three parts. The first outlines the research methodology used, which is based primarily on the main tenets of reception theory and its application to the analysis and criticism of dramatic texts. The second part studies the origins and early manifestations of the doctrinal theater in New Spain and its development during the sixteenth century. The third part, which is the main body of the work, studies the transmission of the legend of the destruction of Jerusalem from the perspective of literary reception through two New Spanish dramatic works: the Auto de la destruccion de Jerusalen, a work written in verse, and the Nican motecpana in inemiliztzin, written in prose in the nahuatl language. This thesis also analyzes certain aspects which have not been dealt with satisfactorily by other critics, such as literary sources, dramatic characteristics, probable date of composition and staging in New Spain during the sixteenth century and so forth. This thesis, therefore, aims to make a positive contribution to a rather neglected field of study: doctrinal theater in New Spain. It also hopes to add to present-knowledge about these two important works.
Information retrieval over the World Wide Web.
Creators: name: Zayour, Iyad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Computer Science.

description: The introduction of the World Wide Web and its increasingly growing popularity have created an immense repository of information. The amount of information, its diversity, and its rapid change caused a major problem--how to use this information effectively and efficiently. Available tools for information retrieval on the Web suffer from many shortcomings in satisfying the information needs for users in a practical way. In this thesis, we try to address some of these problems and to come up with an efficient solution for large portion of these information needs. In particular, we try to create a solution for users interested in locating facts on popular topics--topics which are expected to be queried frequently. Our solution is the "Web Information Collector" System (WIC). The WIC is a Web based system which helps in gathering information from the Web, it permits creating and customizing a local document base to store the gathered information, then it provides novel facilities to query, retrieve and navigate this information. The details of this system will be described in the thesis.
A conceptual framework for community interventions in successful aging
Creators: name: Caron, Catherine M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Gerontology.
subject: Health Sciences, Public Health.

description: As the number and percentage of elderly Canadians increase, it becomes imperative to understand successful aging in order to keep this growing segment of our population healthy and productive. Conceptual models of successful aging have been proposed in a number of disciplines (biology, psychology, sociology, epidemiology), but these have yet to be integrated. There is not even agreement on how to define successful aging, or on whether it is a state of being or an adaptive process. To date, there have been relatively few interventions to promote successful aging, and the lack of a theoretical approach makes it more difficult to design them and to assess the results of any interventions that have been attempted. In this thesis, I build upon the insights from existing literatures, and I propose a conceptual model for successful aging. I then discuss the application of this model to guide community interventions for Successful Aging Ottawa.
Traceability in object-oriented quality engineering: A basis for regression analysis of object-oriented software.
Creators: name: Ben Hajla, Halim.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Computer Science.

description: Object-Oriented (O-O) technology has grown over the past decades into a well defined and increasingly popular style of programming. In this thesis, we introduce a novel method for conducing and managing regression analysis and testing activities during an O-O iterative and incremental development process. The underlying process of the method is based on the following concepts, the Method Sequence Specification (MtSS) and the Message Sequence Specification (MgSS), the class firewall and traceability. A MtSS of a class documents the causal order in which the methods can be invoked upon instantiation of the class. A MgSS for a method in a class documents the causal order in which messages can be sent to different instances of different classes. We use the MtSS and MgSS to detect the changes affecting the class specification and the interactions between classes. We introduce also a regression algorithm to solve the problem of reselection of test cases based on the class specification. Traceability links together user requirements, analysis, design, implementation models and test cases. In our proposal we used it to manage the regression analysis and testing activities and to perform change analysis. The class firewall is computed based on the class implementation affected by changes in the code. (Abstract shortened by UMI.)
La prise de possession canonique et l'exercice de l'office de l'évêque diocésain Étude du canon 382 § 1 et de ses incidences juridiques
Creators: name: Kibanda Mavita, Jean-Robert
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Religion, General.
subject: Law.

description: Le droit actuel affirme que l'évêque désigne à la tête d'un diocèse doit franchir certaines étapes avant de pouvoir exercer son office. Le fait de la désignation sous-entend la réception de la mission canonique qui, elle, suppose la communion de l'élu avec le chef du collège et ses membres. 11 doit évidemment recevoir la "consécration épiscopale" si ce n'est déjà fait, à l'intérieur du temps fixe par le droit. Il doit enfin prendre possession canonique du diocèse qui lui est confié. La prise de possession canonique constitue la dernière étape marquant le début de l'exercice du ministère pastoral du nouvel évêque. Elle est essentielle à l'exercice de l'office de l'évêque diocésain. C'est pourquoi, le can. 382, § 1 interdit à l'évêque désigne d'exercer son office avant d'avoir rempli cette exigence. Le can. 382, § 1 reprend en substance les dispositions du can. 334, § 2 du CIC/17. La consécration épiscopale et la mission canonique ne suffisent pas à l'évêque désigne pour exercer l'office qui lui est confié. En interdisant à l'évêque de s'ingérer dans le gouvernement de son diocèse avant la prise de possession, le can. 382, § I établit l'inhabilité implicite de l'évêque désigné. L'épiscopat comme tel n'est pas un office ecclésiastique et la promotion à la dignité épiscopale ne donne pas droit à l'exercice immédiat de l'office. Il existe deux positions sur la signification juridique de l'institution qui fait l'objet de cette étude. La première, celle défendue récemment par le professeur Arrieta, soutient que la non-observance de cette exigence ne conduit pas à la nullité des actes du fait que le can. 382, § I ne le prescrit pas expressement. L'auteur cite à cet effet le can. 10 sur les lois irritantes et inhabilitantes. L'exigence de la prise de possession canonique serait donc ad liceilatem. La seconde souligne que pour qu'une chose soit dite "expressément", il n'est pas nécessaire qu'elle soit dite "explicitement". Elle peut l'être soit "explicitement", soit "implicitement". La nullité des actes est virtuellement exprimée par le can. 382, § 1 sans être formellement exprimée. L'évêque agirait d'une manière non conforme à la loi s'il arrivait à exercer son office avant qu'il ait pris possession canonique de son diocèse. L'exigence de la prise de possession serait donc ad validitatem, c'est-à-dire elle est requise pour la validité de certains actes du pouvoir de gouvernement.
A Tale of Two Clusters: An Analysis of Gas-phase Metallicity and Nebular Gas Conditions in Proto-cluster Galaxies at z ∼ 2
Creators: name: Alcorn, Leo Y.
name: Gupta, Anshu
name: Tran, Kim Vy
name: Kacprzak, Glenn
name: Yuan, Tiantian
name: Cohn, Jonathan
name: Forrest, Ben
name: Glazebrook, Karl
name: Harshan, Anishya
name: Kewley, Lisa J.
name: Labbe, Ivo
name: Nanayakkara, Themiya
name: Papovich, Casey
name: Spitler, Lee R.
name: Straatman, Caroline M.S.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: The ZFIRE survey has spectroscopically confirmed two proto-clusters using the MOSFIRE instrument on Keck I: One at z = 2.095 in COSMOS and another at z = 1.62 in UKIRT Infrared Deep Sky Survey (UDS). Here, we use an updated ZFIRE data set to derive the properties of ionized gas regions of proto-cluster galaxies by extracting fluxes from emission lines Hβ 4861 Å, [O iii] 5007 Å, Hα 6563 Å, [N ii] 6585 Å, and [S ii] 6716,6731 Å. We measure gas-phase metallicity of members in both proto-clusters using two indicators, including a strong-line indicator relatively independent of the ionization parameter and electron density. Proto-cluster and field galaxies in both UDS and COSMOS lie on the same Mass-Metallicity Relation with both metallicity indicators. We compare our results to recent IllustrisTNG results, which report no significant gas-phase metallicity offset between proto-cluster and field galaxies until z = 1.5. This is in agreement with our observed metallicities, where no offset is measured between proto-cluster and field populations. We measure tentative evidence from stacked spectra that indicate UDS high-mass proto-cluster and field galaxies have differing [O iii]/Hβ ratios; however, these results are dependent on the sample size of the high-mass stacks.
Adaptive user specific learning for environment sensitive hearing aids
Creators: name: Cole, Abimbola Y
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Engineering, Electronics and Electrical.

description: One of the main complaints of hearing aid users is the difficulty of and need for frequent adjustments they have to make to the device. Typically, volume control and other settings prescribed during the hearing aid fitting process still need to be fine-tuned in real life to meet the specific varying needs of the user in different environments. Recently, learning algorithms have been introduced to minimize these problems. By taking a weighted average of the past adjustments, the device is able to adapt to the preferred setting for each environment presented. Typically, fixed learning algorithms are used for all users and environments. In reality, users have different behaviors and the optimum learning time is expected to vary over users and environments. In this thesis, we study the potential for user-specific adaptive learning of the user settings. Profiles of various types of user behaviors were generated and the optimum time constant for learning user preferences was determined in each case using fixed exponential smoothing. We show that the performance of the algorithm is clearly dependent on the user profile and no single fixed time constant is optimum for all users or situations. Three adaptive exponential smoothing methods were then evaluated. Four performance measures are proposed to evaluate these methods based on the users' preferred setting when they re-enter the same environment. For some user profiles, adaptive methods were found to perform as well as the optimum time constant when learning user preferences for volume control without having prior knowledge of the users' behavior. In particular it is shown that the method by W. M. Chow ( Journal of Industrial Engineering, 16, pp. 314-317, 1965) can be tuned to perform as well as the optimum time constant for a given user.
Université de Lorraine's position on the so-called transformative agreements
Creators: name: Bassinet, Aricia
name: Bouchet-Moneret, Florence
name: Delacour, Hélène
name: Dreyer, Erwin
name: Hahusseau, Rudy
name: Lentretien, Celia
name: Lutz, Jean-François
name: Maire, Laure-Hélène
name: Ramdani, Karim
name: Sadowska, Jozefina
Publisher: name: Forschungzentrum Jülich
Year: 2023
Subjects: Transfomative agreements
Open science
Open access
Scientific publications

description: doi:10.5281/ZENODO.7548545
description: The text comes from the Open Publications Operational Committee (COPO) of the Université de Lorraine (UL) and has been validated by the Open Science Steering Committee and the Scientific Council of the institution. It is part of the Open Science strategy of the institution.
L'utilisation de l'article 129 de la Loi sur la défense nationale dans le système de justice militaire Canadien
Creators: name: Cloutier, Jean-Bruno
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Law.

description: Dans un premier temps, cette thèse examine la nature et la gravité relative des infractions d'ordre militaire créées par la partie de la Loi sur la défense nationale connue sous le nom de code de discipline militaire. L'étude fait une révision des systèmes de classifications des infractions militaires proposées par les différentes études qui ont précède les réformes législatives de 1997 et 1999 pour ensuite suggérer une nouvelle taxonomie des infractions. Après avoir situé les infractions prévues au paragraphe 129(1) et 129(2) dans l'échelle de gravité de la gamme des infractions militaires, l'étude s'attarde à l'analyse de la nature des deux infractions distinctes prévues à l'article 129 ainsi qu'à leur utilisation respective devant les deux types de tribunaux militaires pour finalement offrir des suggestions pour palier aux difficultés à la fois d'ordre théorique et pratique dans la conception et l'application de ces infractions pourtant indispensables au bon fonctionnement de la discipline militaire.
Metal catalyzed carbonylation of aziridines, alkynyl epoxides and alpha-allenic alcohols.
Creators: name: Piotti, Marcelo Eduardo.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Chemistry, Organic.

description: This thesis describes the results obtained in the metal catalyzed carbonylation of aziridines, alkynyl oxiranes and $\alpha$-allenic alcohols. Aziridines undergo carbonylation and ring expansion when they are treated with catalytic amounts of Co$\sb2$(CO)$\sb8$ under 33 atm of carbon monoxide in ether solvents at 100$\sp\circ$C, to afford $\beta$-lactams in good to excellent yields. This reaction is applicable to aziridines containing alkyl or aryl groups at the ring carbons, and alkyl, aryl or acyl groups at the nitrogen atom. The reactions in most cases are regioselective, with carbon monoxide insertion occurring into the less substituted ring carbon-nitrogen bond. The carbonylation reaction is also stereoselective, giving trans-3,4-disubstituted $\beta$-lactams when cis-2,3-disubstituted aziridines are used, and vice versa. This stereoselectivity was maintained when fused bicyclic aziridines were subjected to carbonylation, affording the previously unknown trans-7-azabicyclo (4.2.0) otan-8-one derivatives. An X-ray study of one of these novel compounds reveals that the four membered ring contains structural features similar to those found in biologically active $\beta$-lactams, suggesting that these compounds might have considerable acylation power. The mechanism of the reaction involves nucleophilic ring opening of the aziridine ring by the in situ generated Co(CO)$\sb4\sp-$ anion. The carbonylation of aziridines is described in Chapter 2. Palladium (0) complexes catalyze the carbonylation of alkynyl oxiranes to 5-hydroxy-2,3-dienoates in the presence of 20 atm of carbon monoxide and methanol as the solvent. The reaction takes place under mild conditions (room temperature, one to two hours for complete conversion.) The mechanism involves the formation of a zwitterionic $\sigma$-allenylpalladium complex. When the carbonylation reaction is effected on alkynyl oxiranemethanol derivatives, partially saturated furan-3-ol compounds are obtained. These compounds are presumably formed by spontaneous cyclization of a nonisolable allenediol intermediate. Hydrofuran derivatives containing an exo or endo double bond are obtained depending on the substitution pattern of the initial epoxide. An interesting application of this reaction is the synthesis of a chiral furan-3-ol by carbonylation of a chiral epoxy alcohol obtained by Sharpless epoxidation. These results are described in Chapter 3. Chapter 4 describes the carbonylation of $\alpha$-allenic alcohols to $\alpha$-vinylacrylic acids catalyzed by a novel cationic aquo hydride palladium complex. The reaction requires the presence of catalytic amounts of p-toluenesulphonic acid and 20 atm of carbon monoxide to take place. This complex generates a palladium (0) species in situ, which is the active catalyst. The formation of a $\pi$-allylpalladium complex would be a key step in this reaction.
Étude sur la rétention d'arsenic de solutions aqueuses utilisant un traitement au polymère suivi d'une séparation par membrane d'ultrafiltration.
Creators: name: Legault, Anne S.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Engineering, Chemical.

description: A new hybrid method incorporating selective polymeric binding and membrane separation was used to remove arsenic from a synthetic solution representing surface water. Two types of exploitation of this process have been investigated. The first series of experiments were performed in an ultrafiltration Amicon stirred cell, and two types of polymers were used poly-(dially dimethyl ammonium chloride) and polyethylenimine. The second was performed with two different continuous processes, either in a thin channel plate and frame module or in the Amicon stirred cell, using only polyethylenimine. All the solutions were made from $\rm Na\sb2HAsO\sb4$. 7H$\sb2$O which represents the most common degree of oxydation of arsenic in surface water, i.e. As(V). The analysis of arsenic was obtained by combining a hybrid generator with the standard atomic absorption equipment. The evaluation performed to date have demonstrated that the combined method of polymeric binding/ultrafiltration can be used for the removal of arsenic from contaminated water. The proposed technique could be used as a single step method for water treatment or as a post-treatment step after reagent precipitation. Arsenic removal depends on various factors: polymer concentration, pH, anions concentration and types of anions present in the system. The efficiencies obtained during the first series of experiments in presence of salts, NaCl, NaNO$\sb3$, $\rm Na\sb2SO\sb4$, and $\rm Na\sb2CO\sb3$, using Amicon stirred cell varied between 15% at high salt concentrations to 88% at low salt concentrations. The two continuous systems were investigated, feed & bleed and feed only, which represent an industrial process. A maximum efficiency exceeding 99.9% was obtained, even in the presence of 1,000 ppm of sodium chloride. (Abstract shortened by UMI.)
The Effects of Statin and Fibrate Drugs on Cholesterol Metabolism and Steroid Production in Two Fish Species
Creators: name: Al-Habsi, Aziz
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Cholesterol
Statins
Fibrates
Rhabdomyolysis
Lipids

description: Statins and fibrates are the most widely used pharmaceuticals in developed countries for the treatment of hyperlipidemia. They reach the aquatic environment mainly via wastewater treatment plants and have been detected at concentrations of ng to µg/L. They are “pseudopersistent” due to their continuous and increasing input into the aquatic environment. Cholesterol is essential to all animals, so inhibition of its synthesis by these drugs could have negative consequences in non-target species. Currently little is known regarding the possible effects of statins and fibrates on aquatic organisms. Thus, this thesis investigates the effects of atorvastatin (ATV; statin) and gemfibrozil (GEM; fibrate) on rainbow trout and zebrafish in vivo and in vitro. Intraperitoneal injection of ATV, GEM, or the combination of the two drugs (A+G) into rainbow trout resulted in a nearly 30% reduction of cellular cholesterol content. Additionally, gene expression related to lipid homeostasis (LDL-r, HMGCR-1, and SREBP-1) was elevated. Furthermore, plasma creatine kinase activity and skeletal muscle gene expression related to rhabdomyolysis (atrogin-1 and f-box 25) were elevated. Plasma cortisol concentration was reduced in injected trout, suggesting that either the reduction in cholesterol resulted in treated fish lacking a proper stress response or that the treated fish were simply not responsive to the stress protocol. Feeding zebrafish ATV, GEM, or A+G daily over a 30 day period resulted in nearly a 30% reduction of whole-body cholesterol content and a concomitant change in gene expression related to lipid homeostasis (SREBP-1, SREBP-2, HMGCR-1, PPARα, and PPARγ). Moreover, sex steroids (testosterone and estradiol) were also reduced. Finally, exposing rainbow trout hepatocytes to ATV at 4.5 or 45 µg/L for 3 or 6 h resulted in reduced 14C incorporation into cholesterol and cholesteryl ester. Elevated gene expression related to lipid homeostasis (HMGCR-1, SREBP-1, and PPARγ) also occurred. This thesis demonstrated that ATV and GEM affected fish cholesterol and steroid hormone contents, as well as molecular markers of rhabdomyolysis. Whether these changes impact fish fitness remains to be determined.
Congenital diarrhea and cholestatic liver disease: phenotypic spectrum associated with MYO5B mutations
Creators: name: Aldrian, Denise
name: Vogel, Georg F.
name: Frey, Teresa K.
name: Ayyıldız Civan, Hasret
name: Aksu, Aysel Ünlüsoy
name: Avitzur, Yaron
name: Ramos Boluda, Esther
name: Çakır, Murat
name: Demir, Arzu Meltem
name: Deppisch, Caroline
name: Duba, Hans-Christoph
name: Düker, Gesche
name: Gerner, Patrick
name: Hertecant, Jozef
name: Hornová, Jarmila
name: Kathemann, Simone
name: Koeglmeier, Jutta
name: Koutroumpa, Arsinoi
name: Lanzersdorfer, Roland
name: Lev-Tzion, Raffi
name: Lima, Rosa
name: Mansour, Sahar
name: Meissl, Manfred
name: Melek, Jan
name: Miqdady, Mohamad
name: Montoya, Jorge Hernan
name: Posovszky, Carsten
name: Rachman, Yelena
name: Siahanidou, Tania
name: Tabbers, Merit
name: Uhlig, Holm H.
name: Ünal, Sevim
name: Wirth, Stefan
name: Ruemmele, Frank M.
name: Hess, Michael W.
name: Huber, Lukas A.
name: Müller, Thomas
name: Sturm, Ekkehard
name: Janecke, Andreas R.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: congenital diarrheal diseases
subject: enteropathy
subject: microvillus inclusion disease
subject: MYO5B
subject: myosin Vb
subject: progressive familial intrahepatic cholestasis
subject: PFIC
subject: genotype–phenotype correlation
subject: lack of protein
subject: tail domain
subject: DDC 610 / Medicine & health
subject: Diarrhea
subject: Cholestasis
subject: Myosins
subject: Kontraktile Proteine
subject: Cholestase
subject: Durchfall
subject: Myosin

description: Myosin Vb (MYO5B) is a motor protein that facilitates protein trafficking and recycling in polarized cells by RAB11- and RAB8-dependent mechanisms. Biallelic MYO5B mutations are identified in the majority of patients with microvillus inclusion disease (MVID). MVID is an intractable diarrhea of infantile onset with characteristic histopathologic findings that requires life-long parenteral nutrition or intestinal transplantation. A large number of such patients eventually develop cholestatic liver disease. Bi-allelic MYO5B mutations are also identified in a subset of patients with predominant early-onset cholestatic liver disease. We present here the compilation of 114 patients with disease-causing MYO5B genotypes, including 44 novel patients as well as 35 novel MYO5B mutations, and an analysis of MYO5B mutations with regard to functional consequences. Our data support the concept that (1) a complete lack of MYO5B protein or early MYO5B truncation causes predominant intestinal disease (MYO5B-MVID), (2) the expression of full-length mutant MYO5B proteins with residual function causes predominant cholestatic liver disease (MYO5B-PFIC), and (3) the expression of mutant MYO5B proteins without residual function causes both intestinal and hepatic disease (MYO5B-MIXED). Genotype-phenotype data are deposited in the existing open MYO5B database in order to improve disease diagnosis, prognosis, and genetic counseling.
“What About Automated Pain Recognition for Routine Clinical Use?” A Survey of Physicians and Nursing Staff on Expectations, Requirements, and Acceptance
Creators: name: Walter, Steffen
name: Gruss, Sascha
name: Frisch, Stephan
name: Liter, Joseph
name: Jerg-Bretzke, Lucia
name: Zujalovic, Benedikt
name: Barth, Eberhard
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: automated pain recognition
subject: acceptance
subject: benefit
subject: multimodal
subject: DDC 610 / Medicine & health
subject: Pain
subject: Pain management
subject: Artificial intelligence
subject: Algesimetrie
subject: Künstliche Intelligenz

description: Background: Over the last 12 years, the fundamentals of automated pain recognition using artificial intelligence (AI) algorithms have been investigated and optimized. The main target groups are patients with limited communicative abilities. To date, the extent to which anesthetists and nurses in intensive care units would benefit from an automated pain recognition system has not been investigated. Methods: N = 102 clinical employees were interviewed. To this end, they were shown a video in which the visionary technology of automated pain recognition, its basis and goals are outlined. Subsequently, questions were asked about: (1) the potential benefit of an automated pain recognition in clinical context, (2) preferences with regard to the modality used (physiological, paralinguistic, video-based, multimodal), (3) the maximum willingness to invest, (4) preferences concerning the required pain recognition rate and finally (5) willingness to use automated pain recognition. Results: The respondents expect the greatest benefit from an automated pain recognition system to be “to avoid over- or undersupply of analgesics in patients with limited communicative abilities,” a total of 50% of respondents indicated that they would use automated pain recognition technology, 32.4% replied with “perhaps” and 17.4% would not use it. Conclusion: Automated pain recognition is, in principle, accepted by anesthetists and nursing staff as a possible new method, with expected benefits for patients with limited communicative skills. However, studies on automated pain recognition in a clinical environment and proof of its acceptance and practicability are absolutely necessary before such systems can be implemented.
Self-aligning and flexible dielectric waveguide plug for MMICs at G-Band
Creators: name: Geiger, Martin
name: Hitzler, Martin
name: Mayer, Winfried
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Mechanical decoupling
subject: MMIC-to-dielectric waveguide transition
subject: Self-alignment
subject: DDC 620 / Engineering & allied operations
subject: Wave guides
subject: Dielectric wave guides
subject: Microwave integrated circuits
subject: Machinery; Alignment
subject: Dielektrischer Wellenleiter
subject: MMIC
subject: Integrierte Mikrowellenschaltung
subject: Ausrichten (Technik)

description: The packaging technology for transitions to dielectric waveguides in the frequency range above 100 GHz is complex and must be highly precise, and the waveguides are usually permanently connected. This letter presents a transition from a monolithic microwave integrated circuit (MMIC) to a ﬂexible dielectric waveguide at G-Band (140–220 GHz), which is self-aligning and, thus, reduces the requirements for packaging accuracy. Furthermore, the transition is mechanically decoupled to avoid mechanical stress to the MMIC and to reconnect it arbitrarily often. A patch radiator on a quartz-glass carrier is excited by a coupler on the MMIC. It feeds the HE11 mode into a rigid, high-permittivity dielectric dome, which increases the coupling efﬁciency. The ﬂexible dielectric waveguide is placed above the dome and ﬁxed with Rohacell half shells. The minimum insertion loss measured with a back-end-of-line (BEOL) MMIC is 3.0 dB at 168 GHz.
Stories of Open Science: Fostering the next generation and adapting to local realities - Dr. Reina Camacho Toro
Creators: name: Kim, Steffie
name: Martinez, Isabella
name: Camacho Toro, Reina
Publisher: name: Forschungzentrum Jülich
Year: 2022

description: doi:10.5281/ZENODO.7044841
description: Stories of Open Science: Fostering the next generation and adapting to local realities. Dr. Reina Camacho Toro is an experimental particle physicist and a member of the ATLAS collaboration at CERN. She is also part of a European-Latin American network creating postgraduate courses in advanced physics guided by the principles of open science and education at LA-CoNGA physics. “You need to adapt to the realities of the community you are working with. We have to be aware that open science can take different shapes based on where you are and where you're coming from.”
Stakeholders' perspectives of the skills and attributes for accounting graduates
Creators: name: Hancock, Phil
name: Howieson, Bryan
name: Kavanagh, Marie
name: Kent, Jenny
name: Tempone, Irene
Publisher: name: Swinburne
Year: 2024

description: This study examines how a group of Australian stakeholders define technical and nontechnical skills, identifies those skills that are demanded of graduates at various stages of their career, and assesses the level of stakeholder satisfaction with the skills level of accounting graduates. Further the paper attempts to highlight the views of stakeholders about whose responsibility it is to develop the required set of technical and non technical skills required by accounting graduates as they enter the workforce. Findings indicate that employers are seeking graduates who possess a diverse range of non-technical skills including communication and presentation, self-management, teamwork, initiative and enterprise, problem solving, technological competence and planning and organising skills. Employers also use non-technical skills as discriminators when evaluating graduates. In terms of technical skills basic practical accounting skills, IT skills and industry specific awareness are important. In general employers were not satisfied with the level of communication and problem solving skills and seemed generally to have low expectations in the area of technical skills accepting that they undertake much of the technical training themselves. The discussion about who role it was to develop both technical and non technical skills was most clearly stated as that of the universities. The findings have implications for those involved in the training of accountants and indeed for those seeking to develop skills in order to enter the profession.
Služby Centra pro podporu open science
Creators: name: Grofová, Šárka
name: Simandlová, Tereza
Publisher: name: Forschungzentrum Jülich
Year: 2020
Subjects: open access
research data management
scholarly communication

description: doi:10.5281/ZENODO.4003648
description: Na tomto letáku naleznete shrnutí služeb, které Centrum pro podporu open science nabízí studentům a zaměstnancům Univerzity Karlovy.
The Evolution of O I over 3.2 z 6.5: Reionization of the Circumgalactic Medium
Creators: name: Becker, George D.
name: Pettini, Max
name: Rafelski, Marc
name: D'odorico, Valentina
name: Boera, Elisa
name: Christensen, Lise
name: Cupani, Guido
name: Ellison, Sara L.
name: Farina, Emanuele Paolo
name: Fumagalli, Michele
name: López, Sebastian
name: Neeleman, Marcel
name: Ryan-Weber, Emma
name: Worseck, Gábor
Publisher: name: Swinburne
Year: 2024

description: We present a survey for metal absorption systems traced by neutral oxygen over 3.2 < z < 6.5. Our survey uses Keck/ESI and VLT/X-Shooter spectra of 199 QSOs with redshifts up to 6.6. In total, we detect 74 O i absorbers, of which 57 are separated from the background QSO by more than 5000 km s-1. We use a maximum likelihood approach to fit the distribution of O i λ1302 equivalent widths in bins of redshift and from this determine the evolution in number density of absorbers with W 1302 > 0.05 Å, of which there are 49 nonproximate systems in our sample. We find that the number density does not monotonically increase with decreasing redshift, as would naively be expected from the buildup of metal-enriched circumgalactic gas with time. The number density over 4.9 < z < 5.7 is a factor of 1.7-4.1 lower (68% confidence) than that over 5.7 < z < 6.5, with a lower value at z < 5.7 favored with 99% confidence. This decrease suggests that the fraction of metals in a low-ionization phase is larger at z ∼ 6 than at lower redshifts. Absorption from highly ionized metals traced by C iv is also weaker in higher-redshift O i systems, supporting this picture. The evolution of O i absorbers implies that metal-enriched circumgalactic gas at z ∼ 6 is undergoing an ionization transition driven by a strengthening ultraviolet background. This in turn suggests that the reionization of the diffuse intergalactic medium may still be ongoing at or only recently ended by this epoch.
Regions of the CD127 Cytoplasmic Tail Necessary for HIV-1 Tat Binding
Creators: name: Cherid, Hafsa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: HIV-1 Tat
IL-7 receptor
CD127

description: Impaired cell mediated immunity is the clinical hallmark of HIV infection yet the manner in which CD8 T-cells are disabled is not yet fully understood. IL-7 signalling is essential for normal CD8 T-cell development and function. Our lab has previously shown decreased expression of the IL-7 receptor a-chain (CD127) on circulating CD8 T-cells in HIV+ patients is mediated by the HIV Tat protein which results in poor CD8 T-cell function. Soluble Tat protein is secreted by infected CD4 T-cells and taken up by neighbouring uninfected CD8 T-cells through endocytosis. Once in the cytoplasm, Tat translocates to the inner leaflet of the cell membrane where it binds directly to the cytoplasmic tail of CD127 inducing receptor aggregation, internalization, and degradation by the proteasome. By removing CD127 from the cell surface, the HIV Tat protein is able to reduce IL-7 signaling and impair CD8 T-cell proliferation and function. To determine which domain(s) in the cytoplamic tail of CD127 are required for interaction with Tat, a series of plasmids encoding for CD127 deletion mutants were successfully created. These series of mutant CD127 coding sequences were transfected into a eukaryotic expression system, the Jurakt cell line, where CD127 mutants were successfully expressed. Before determine which region on CD127 is required for Tat binding, an optimized Ni-NTA column system was used to successfully isolate histidine-tagged HIV-1 Tat at a high yield and purity from E. coli. This HIV Tat protein was used to treat the lysates of the Jurakt cells transfected with the panel of CD127 mutants. CD127 was then immunoprecipitated, followed by Western analysis of the immune complexes to detect Tat protein. Tat was immunoprecipitated with all CD127 mutants suggests neither tyrosine 449, box 1, the acidic region, serine region nor C-tail are specifically required for Tat binding to CD127.