cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 10 of Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study
Creators: name: Lin, Yindan
name: Yang, Ze
name: Li, Jingjia
name: Sun, Yandi
name: Zhang, Xueyun
name: Qu, Zihao
name: Luo, Yan
name: Zhang, Lihong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 10: Table S1. MR analysis using different methods for genetic associations between aspartate and prostate cancer1.
title: Redéfinir les frontières du surendettement : quel problème pour quel public ? ( LIEPP Policy Brief, n°26)
Creators: name: Lazarus, Jeanne
name: Morival, Yohann
Publisher: name: Sciences Po - LIEPP
Year: 2016
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Les évolutions des politiques de lutte contre le surendettement constituent un poste d’observation privilégié de la lutte contre la pauvreté : la figure du surendetté se transforme parallèlement aux mutations des malheurs socioéconomiques perçus comme légitimes. L’entrée par les Points conseil budget (PCB), un dispositif d’action publique actuellement en expérimentation, signale une innovation notable : l’inclusion des questions bancaires dans la lutte contre le surendettement. L’approche préventive promue par les PCB s’accompagne d’une redéfinition des publics visés par la lutte contre le surendettement. En insistant sur les frontières fluctuantes de la figure du surendetté et sur ses conséquences, nous décrivons la difficulté à penser un dispositif d’action publique sans public clairement identifié.
Produção de metano entérico por ovinos em sistema silvipastoril de eucalipto e capim massai
Creators: name: Alari, Fernando De Oliveira
name: Spasiani, Paola Palauro
name: Abmael Da Silva Cardoso
name: Nomaiací De Andrade
name: Reis, Ricardo Andrade
name: Ruggieri, Ana Cláudia
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 40107 Meteorology
subject: FOS: Earth and related environmental sciences

description: O metano (CH4) é o segundo gas de efeito estufa mais importante. Na produção animal sua emissão está principalmente relacionada a fermentação do alimento no rúmen. Entre 3 e 9% da energia bruta ingerida pelos animais é perdida na forma de CH4. Com a intensificação do aumento da temperatura média do globo terrestre formas de mitigar a emissão de CH4 necessitam ser investigadas. Uma alternativa pode ser a inclusão de árvores em sistemas pastoris levando a uma alteração na composição química do alimento e também no desempenho animal o que pode levar a uma redução na emissão total ou por unidade de produto de CH4. O objetivo desta pesquisa foi quantificar a emissão de CH4 por ovinos e a composição química do capim massai sobre 3 níveis de sombreamento em sistema silvipastoril. O delineamento utilizado foi o inteiramente casualizado sendo os tratamentos 3 níveis de sombreamento pleno sol (sem árvores, moderado (com eucalipto espaçado 12m entre linhas) e intenso (com eucalipto espaçado 6m entre linhas) com 6 repetições. A composição química da forragem e a emissão de CH4 entérico foram avaliados por 3 anos seguidos (2013 a 2015). A composição química do capim não apresentou diferenças entre os níveis de sombreamento assim como entre anos. Ao analisar a composição bromatológica do capim massai o teor médio de proteína bruta foi 10%, fibra em detergente ácido 69,3%, fibra em detergente neutro 38,1%, hemicelulose 31,2%, celulose 33.5% e lignina 4,7% com base na matéria seca. A emissão de CH4 entérico não diferiu entre níveis de sombreamento, porém foi afetada pelos anos de avaliação. No primeiro ano a produção de CH4 por animal foi 5,8, 7,1 e 6,2 kg CH4 animal-1, no segundo 10,2, 9,2 e 9,4 kg CH4 animal-1 e no terceiro 8,5, 7,3 e 7,0 kg CH4 animal-1. A ausência de efeito dos níveis de sombreamento sobre a composição bromatológica do capim massai significa que nos arranjos arbóreos estudados não afetou os mecanismos fisiológicos que levam a alteração na formação dos compostos nitrogenados e fibra na planta. Essa ausência de efeito sobre a composição química também explica a produção similar de CH4 entre os níveis de sombreamento. Já a diferença entre anos pode ser atribuída a características intrínsecas aos animais que eram diferentes entre os anos. Os níveis de sombreamento utilizados podem ser adotados em sistemas de produção silvipastoris sem alterar a composição química da forrageira, porém, não se constitui em uma alternativa a mitigação de CH4 entérico.
title: Quels effets de la rénovation urbaine sur les quartiers ciblés ? ( LIEPP Policy Brief, n°29)
Creators: name: Guyon, Nina
Publisher: name: Sciences Po - LIEPP
Year: 2017
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Depuis 2004, le PNRU vise à restructurer 571 quartiers parmi les plus défavorisés de France dans un objectif de mixité sociale et d’amélioration du cadre de vie dans ces quartiers. En 2013, plus de 200 000 logements avaient ainsi été démolis ou construits, et plus de 200 000 autres réhabilités, pour un montant total investi par l’Etat de 45 milliards d’euros. La comparaison de l’évolution de ces quartiers à celle des Zones Urbaines Sensibles n’ayant pas bénéficié du programme montre que le PNRU a induit, en dix ans, une modeste diminution du niveau de pauvreté dans les quartiers ciblés (-1 point de pourcentage de la proportion de ménages du premier quartile de revenus), qui est nettement plus prononcée dans les quartiers où les démolitions ont été les plus intenses (-4,5 points). Ce résultat est donc encourageant sur le plan de la mixité sociale. En revanche cette diminution s’observe uniquement dans le parc social et le niveau de pauvreté a au contraire augmenté dans le parc privé. Qui plus est, dans le parc social, la diminution observée semble s’expliquer principalement par le fait que les démolitions ont ciblé les logements des ménages les plus pauvres et par leur relogement dans d’autres quartiers, et non par l’arrivée de ménages plus aisés dans les nouveaux logements. Ces derniers résultats soulignent l'importance de ne pas relâcher les efforts visant à renforcer l’attractivité des quartiers ciblés, par exemple sur le plan de l’amélioration du cadre de vie et des transports, notamment dans la mise en œuvre actuelle des nouvelles politiques de rénovation urbaine
Ambience of dairy cattle raised on low profile cross ventilation barn considering different animal categories and work shifts
Creators: name: Aérica C. Nazareno
name: Filho, Arthur A. Ortenblad
name: Silva, Iran José O. Da
name: Machado, Miguel
Publisher: name: CBBiomet 2017
Year: 2017
Subjects: subject: 40107 Meteorology
subject: FOS: Earth and related environmental sciences

description: The objective of this reseach was to evaluate the Low Profile Cross Ventilation (LPCV) system’s microclimate in order to observe dairy cattle thermal comfort, by means of physiological indicators on different animal categories and working shifts. This project was conducted during fall in the State of São Paulo. For the microclimatic evaluation the air temperature, relative humidity and internal/external specific enthalpy were recorded by two dataloggers for 30 minutes intervals for 21 days. The physiological parameters (surface temperature, rectal temperature and respiratory frequency) were measured from 28 cows from different productive categories and working shifts. The experimental design was completely randomized in the 3x2 factorial scheme, including 9 repetitions. It was concluded that the Low Profile Cross Ventilation (LPCV) barn during fall showed efficiency for controlling the environment for the differents animal categories and work shifts studied, where all dairy cows were within the range of values for their thermal comfort.
Genome-Wide Association Mapping for Drought Tolerance Traits at Seedling Stage Using Nebraska Winter Wheat
Creators: name: Shamseldeen Eltaher
name: Sallam, Ahmed
name: Belamkar., Vikas
name: Emara, Hamdy A.
name: Nower, Ahmed A.
name: Salem, Khaled F M
name: Poland, Jesse
name: P. Stephen Baenziger
Publisher: name: figshare
Year: 2017
Subjects: subject: 60405 Gene Expression (incl. Microarray and other genome-wide approaches)
subject: FOS: Biological sciences
subject: Genetics
subject: 60407 Genome Structure and Regulation
subject: 60408 Genomics
subject: Plant Biology
subject: 60411 Population, Ecological and Evolutionary Genetics

description: Wheat (Triticum aestivum L.) is the first important and strategic cereal crop around the world. Wheat crop has been widely cultivated in very diverse environments, this means it is exposed to different biotic and abiotic stresses. Drought tolerance becoming one of the most challenge in the wheat breeding program. The most critical problem in wheat production is the shortage of water at the seedling stage, mid-season water stress, terminal stress or a combination of any two or three stages. So, the detection of genotypes variation in drought tolerance at seedling stage could help in selection intensity in the wheat breeding program for drought tolerance. In this study 157 genotypes of winter wheat in addition three checks variety (Anton, Harry as drought tolerant checks and Wesley drought susceptible check) were grown in uncontrolled greenhouse. Three drought traits were taken (days to wilting DW, leaf wilting degree LWD and stay green SG) all of these traits were visual scored and ranged from (1 no wilted or yellow color to 9 full wilted or green plants). LWD was scored 4 times each two days and all scored was summed to only one trait sum of wilting degree SWD. Highly genetic variation was found in all observed traits and the genetic heritability was found 91.44, 91.32 and 86.86 for all traits, respectively. Highly significant correlation was observed between all traits under investigation. Genome wide association study GWAS was performed using 9,765 single nucleotide polymorphism SNPs marker using mixed liner model with 20% false discovery rate and identified ten SNPs associated with two drought traits i.e., days to wilting (DTW) and sum of wilting degree (SWD). In total, ten marker-trait associations MTAs were detected. Two SNPs in the 6B chromosome were associated with SWD. Also, eight SNPs were associated with DTW three in chromosome 6B and four in 2D and one in chromosome 5B. Key words: GWAS, Drought tolerance, Winter Wheat, Seedling stage
Supplement_to_Approximate_tests_for_the_equality_of_two_cumulative_incidence_functions_of_a_competing_risk
Creators: name: Dobler, Dennis
name: Pauly, Markus
Publisher: name: figshare
Year: 2017
Subjects: subject: 10405 Statistical Theory
subject: FOS: Mathematics

description: This is the supplementary material to the article by Dobler and Pauly (2017), “Approximate tests for the equality of two cumulative incidence functions of a competing risk”. The reader will find two additional set-ups complementing the frailty scenario 3 of the main manuscript as well as a fourth simulation set-up including tables presenting the results as well as a detailed evaluation of the considered tests.

References
 D. Dobler and M. Pauly. Approximate tests for the equality of two cumulative incidence functions of a competing risk. Statistics. DOI = 10.1080/02331888.2017.1336171, 2017.
Supplementary text, figures, and tables from Common species link global ecosystems to climate change: dynamical evidence in the planktonic fossil record
Creators: name: Hannisdal, Bjarte
name: Haaga, Kristian Agasøster
name: Reitan, Trond
name: Diego, David
name: Liow, Lee Hsiang
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Contains supplementary text describing statistical methods, supplementary figures S1-S8, and supplementary tables S1 and S2.
supplement.pdf
Creators: name: Dobler, Dennis
name: Pauly, Markus
Publisher: name: figshare
Year: 2017
Subjects: subject: 10405 Statistical Theory
subject: FOS: Mathematics

description: This is the supplementary material to the article by Dobler and Pauly (2017), “Approximate tests for the equality of two cumulative incidence functions of a competing risk”. The reader will find two additional set-ups complementing the frailty scenario 3 of the main manuscript as well as a fourth simulation set-up including tables presenting the results as well as a detailed evaluation of the considered tests.

References
 D. Dobler and M. Pauly. Approximate tests for the equality of two cumulative incidence functions of a competing risk. Statistics. DOI = 10.1080/02331888.2017.1336171, 2017.
Additional file 9 of Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study
Creators: name: Lin, Yindan
name: Yang, Ze
name: Li, Jingjia
name: Sun, Yandi
name: Zhang, Xueyun
name: Qu, Zihao
name: Luo, Yan
name: Zhang, Lihong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 9: Fig. S9. Single MR estimates from each of the genetic variants using MR-Egger method. The black scatter plots indicate single causal estimates from each of the genetic variants associated with serum aspartate or glutamate level on the x-axis and prostate cancer or breast cancer on the y-axis. The continuous line represents the causal effect of serum aspartate or glutamate level on prostate cancer or breast cancer. (a-b). The estimates between aspartate and cancers using 3 independent SNPs with P value < 5×10−8, (a). Prostate cancer; (b). Breast cancer. (c-d). The estimates between aspartate and cancers using 13 independent SNPs with P value < 5×10−6, (c). Prostate cancer; (d). Breast cancer. (e-f). The estimates between glutamate and cancers using 5 independent SNPs with P value < 5×10−6, (e). Prostate cancer; (f). Breast cancer.
title: Faut-il changer les règles de revalorisation automatique du SMIC ? ( LIEPP Policy Brief, n°05)
Creators: name: Cette, Gilbert
name: Wasmer, Etienne
Publisher: name: Sciences Po - LIEPP
Year: 2012
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Depuis 1970, le SMIC est revalorisé automatiquement en fonction de l'inflation et de la croissance du pouvoir d'achat ouvrier mesuré par le SHBO (Salaire Horaire de Base Ouvrier). Le gouvernement peut en outre revaloriser le SMIC par un « coup de pouce » discrétionnaire qui s'ajoute à la revalorisation automatique. Depuis 2009, un comité d'experts indépendants donne une recommandation sur ce coup de pouce, dont le gouvernement peut s'écarter en justifiant son choix. En 2012, de nouvelles règles de revalorisation automatique basées notamment sur la croissance du PIB sont discutées. Cette note de synthèse souligne les écueils de certains aspects d'une telle réforme, compte tenu des données disponibles et de leurs limitations, et fait quatre propositions relatives aux indicateurs de revalorisation et aux modalités d'application des règles.
description: Since 1970, the French Minimum Wage is indexed on inflation and half of the growth of real wages of blue collar workers (SHBO or Salaire Horaire de Base Ouvrier). Moreover, the government can give the minimum wage an additional boost ('coup de pouce') at its own discretion. Since 2009, a minimum wage committee with
independent experts gives a recommendation on this 'additional boost', and the government may or may not follow its recommendation, but with public justification. In 2012, new indexation rules are discussed, including some based on real GDP. This note reviews the different possibilities given data availability and concludes.
The role of vaginal acidity: The production of glycogen and it's role on determining the gender of the fetus
Creators: name: Aly, Islam Atef
Publisher: name: figshare
Year: 2017
Subjects: Biological Techniques

description:
This paper describes the important role of the vaginal acidity not only in the health of the vagina, but also in determining the gender of the fetus, we have put in mind that where there is vaginal acidity, so we should connect this to the production of oestrogen hormones, putting in mind the cases that lead to high oestrogen level.
Should groundwater be used for drinking purposes?
Creators: name: Ng, Wenfa
Publisher: name: figshare
Year: 2017
Subjects: subject: 90410 Water Treatment Processes
subject: FOS: Chemical engineering
subject: 90508 Water Quality Engineering
subject: FOS: Civil engineering
subject: 90509 Water Resources Engineering
subject: 40608 Surfacewater Hydrology
subject: FOS: Earth and related environmental sciences
subject: 90701 Environmental Engineering Design
subject: FOS: Environmental engineering
subject: 90702 Environmental Engineering Modelling

description: Groundwater is an important source of drinking water in many parts of the world, but is it safe? How should we make it safer? Pumped from underground aquifers which are recharged by percolation of rainwater through the soil, groundwater is freshwater that may harbour various organic, inorganic and microbiological contaminants. Specifically, inorganic contaminants such as boron, nitrate, chromium, manganese, copper, nickel and arsenic ranks as serious pollutants with human health significance. Current methods for treating groundwater follows the conceptual thought flow for river and reservoir water treatment: sedimentation, coagulation, sedimentation, slow sand filtration, and disinfection by chlorine and ultraviolet light. However, the above process train is unable to remove trace contaminants such as heavy metals, which may impact on human health. Thus, depending on the contaminants load, groundwater may require expensive advanced water treatment methods such as hollow fibre ultrafiltration and reverse osmosis. High pressure and with high energy consumption, ultrafiltration and reverse osmosis addon to conventional drinking water treatment process would make groundwater safe for drinking, but society needs to judge the cost-benefit ratio in the case where alternative cleaner sources of drinking water is available, for example, rivers and freshwater reservoirs. Overall, while technologies exist to make groundwater safe for consumption, high price and poor accessibility of these advanced water treatment techniques such as reverse osmosis makes siting a settlement or town near a river or freshwater lake critical from the perspective of provision of clean drinking water. Additionally, faster than recharge rates withdrawal of groundwater also led to untoward land subsidence, which may bring about other issues such as saltwater intrusion into groundwater aquifers near coastal areas. Thus, if freshwater is available from a nearby lake or reservoir, groundwater use in the view of an expanding population is a poor policy option as the easier and safer route is often expanding water catchment areas and freshwater reservoirs.
title: Evaluer les impacts du crédit d’impôt pour la compétitivité et l’emploi ( LIEPP Policy Brief, n°27)
Creators: name: Carbonnier, Clément
name: Malgouyres, Clément
name: Rot, Gwenaële
Publisher: name: Sciences Po - LIEPP
Year: 2016
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description:  Le Crédit d'Impôt pour la Compétitivité et l'Emploi (CICE) a été institué avec l'objectif d'améliorer la compétitivité des entreprises. Pour étudier les différents effets potentiels du CICE (appropriation du dispositif, effet sur l’emploi, les salaires, l’investissement, les exportations), l’évaluation présentée ici combine deux méthodologies issues de la sociologie économique, d’une part, et de l’économie quantitative, d’autre part. Ce type de dialogue étant rarement mené en sciences sociales, cette évaluation du LIEPP est un objet scientifique unique. Les conclusions des deux approches se recoupent assez largement ce qui assoit leur crédibilité. Une enquête de terrain auprès des décisionnaires d’entreprises indique que le recours au CICE a été important, et a été rapidement intégré dans les routines de gestion fiscale des entreprises, en étant perçu comme fongible. Les entretiens indiquent un effet diffus: s’il est apprécié en tant que dispositif – indirect – d’allègement des charges qui participe à l’amélioration des résultats économiques, il semble avoir changé peu de choses dans la manière dont les entreprises étudiées sont administrées. Toutefois, le CICE, par le biais du préfinancement, offre un nouveau guichet de financement aux entreprises pour consolider la trésorerie ou réduire le montant des dettes. En ce sens, malgré son coût, il intéresse celles qui sont en difficulté ou dont les besoins en trésorerie sont importants puisqu’il permet de convertir un crédit d’impôt en ressource financière immédiate. L’analyse micro-économétrique sur des données sociales et fiscales d’entreprises fait apparaître que, comparativement aux entreprises moins intensément ciblées par le CICE, les entreprises les plus intensément ciblées par le CICE n'ont pas connu de hausse des exportations, des investissements ou de l'emploi en 2013 et en 2014, toutes choses égales par ailleurs (à taille d’entreprise et secteurs comparables notamment). Le résultat net des entreprises s'est en revanche relevé grâce au CICE. Ce résultat net a été en partie redistribué sous forme de salaire : le salaire horaire a davantage augmenté dans les entreprises bénéficiant plus du CICE. Notre analyse quantitative ne permet pas de déterminer s’il s’agit du salaire de base ou des accessoires de salaire, mais notre analyse qualitative semble indiquer qu’il s’agirait plutôt de ces derniers. Les conclusions de l’évaluation ne portent que sur les deux premières années de mise en place du CICE, les données 2015 et 2016 n’étant pas encore disponibles. Il convient enfin de préciser la difficulté de toute étude portant sur le CICE : celui-ci n’a pas été conçu de manière à être évalué par un dispositif expérimental.
title: Faut-il élargir les allègements de cotisations sociales aux salaires élevés ? ( LIEPP Policy Brief, n°06)
Creators: name: Carbonnier, Clément
Publisher: name: Sciences Po - LIEPP
Year: 2013
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Le rapport Gallois préconise un élargissement des allègements de cotisations sociales pour des salaires élevés. Dans cette optique un crédit d’impôt aux entreprises est entré en vigueur au 1er janvier 2013. Ces mesures visent à aider l’industrie française à investir dans une montée en gamme afin d'améliorer sa compétitivité sur les marchés internationaux. Ce nouvel essor de l’industrie profiterait alors à d’autres secteurs d’activité via les emplois induits. Cependant, si on peut effectivement s’attendre à une transformation en qualité et en quantité de l’industrie française, l’impact de telles mesures resterait limité. En effet, les bénéfices de tels allègements de cotisations sociales ne se traduiraient que partiellement en baisse du coût du travail, mais également en hausse des salaires et des dividendes. Ce phénomène d’incidence devra être estimé lors de l’évaluation ex post de cette politique publique.
description: The Gallois report points out the necessity of an increase of payroll tax rebates. This leads to a corporate tax credit effective since January 1st 2013. Such rebates would help French manufacturing to increase its international demand through quality improvement. In addition, spillovers would benefit to other activities. However, this positive impact would be limited by tax incidence phenomenon. The payroll tax rebates would be shared with workers through wage increases and owners through dividend increases and would benefit only partially to price decreases and quality investments. This incidence phenomenon should be part of the ex post evaluation of the tax credit.
Results of the telephone survey on quitting smoking in Ukraine
Creators: name: Andreeva, Tatiana
name: Petrenko, Tatiana
name: Krasovsky, Konstantin
Publisher: name: figshare
Year: 2017
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Andreeva, T. I., Petrenko, T., & Krasovsky, K. S. (2016). Results of the telephone survey on quitting smoking in Ukraine. Survey report.
title: sainte Restitute
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Vierge africaine, martyrisée à la fin du IIIe siècle ; représentée sur une barque en flammes avec un ange gardien à ses côtés.
title: Enrichment of putative plant growth promoting microorganisms in biodynamic compared with organic agriculture soils
Creators: name: Milke, Felix
name: Rodas-Gaitan, Heberto
name: Meissner, Georg
name: Masson, Vincent
name: Oltmann, Meike
name: Möller, Morten
name: Wohlfahrt, Yvette
name: Kulig, Boris
name: Acedo, Alberto
name: Athmann, Miriam
name: Fritz, Jürgen
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: microbiome
subject: agriculture
subject: biodynamic
subject: organic
subject: biodynamic preparation
subject: soil health
subject: biofertilizer
subject: soil
subject: biological amendment
subject: 630
subject: Boden
subject: Bodenmikrobiologie
subject: Pflanzenwachstum
subject: Mikoroorganismus

description: Corrected and typeset: 30. März 2024
description: Gefördert durch den Publikationsfonds der Universität Kassel
The difficult journey to treatment for women suffering from heavy menstrual bleeding: a multi-national survey
Creators: name: da Silva Filho, A. L.
name: Caetano, C.
name: Lahav, A.
name: Grandi, G.
name: Lamaita, R. M.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Up to 30% of women of reproductive age experience HMB, which has a substantial impact on their quality of life. A clinical care pathway for women with HMB is an unmet need, but its development requires better understanding of the factors that characterise current diagnosis and management of the condition. This observational, survey-based study assessed the burden, personal experiences, and path through clinical management of women with HMB in Canada, the USA, Brazil, France and Russia using a detailed, semi-structured online questionnaire. After excluding those reporting relevant organic pathology, responses to the questionnaire from 200 women per country were analysed. Around 75% of women with HMB had actively sought information about heavy periods, mostly through internet research. The mean time from first symptoms until seeking help was 2.9 (Standard deviation, 3.1) years. However, 40% of women had not seen a health care professional about the condition. Furthermore, 54% had never been diagnosed or treated. Only 20% had been diagnosed and received appropriate treatment. Treatment was successful in 69% of those patients currently receiving treatment. Oral contraceptives were the treatment most commonly prescribed for HMB, although the highly effective levonorgestrel-intrauterine system was used by only a small proportion of women. This study provides insight into the typical journey of a woman with HMB which may help patients and health care professionals improve the path to diagnosis and treatment, although further research with long-term outcomes is needed.
Trends in the use of hormonal contraception in Estonia 2005–2019 and the risk of arterial and venous thromboembolism: a population-based study
Creators: name: Kurvits, Katrin
name: Laius, Ott
name: Uusküla, Maia
name: Laanpere, Made
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: To describe trends in hormonal contraceptive use, incidence of thromboembolism and presence of risk factors for thromboembolism among the users in Estonia. Data of 223 312 female patients aged 15–49 years in 2005–2019 from national health insurance databases was derived. Annual prevalence rates of hormonal contraceptive users, incidence rates of thromboembolism and prevalence rates of risk factors were calculated. Between 2005–2019 usage of progestogen-only contraceptives (POCs) increased steadily (from 24 to 135 users per 1000 population), whereas combined hormonal contraceptive (CHC) use declined (from 209 in 2012 to 161 users per 1000 population in 2019). During the study period, 390 cases of venous thromboembolism and 108 arterial thromboembolism coincided with hormonal contraceptive use. Incidence rate for venous thromboembolism was 5.0 (95% CI 4.5–5.5) and for arterial thromboembolism 1.4 per 10 000 person-years (95% CI 1.1–1.7) among hormonal contraceptive users. Age adjusted incidence of venous thromboembolism among CHC users was 5.8 (95% CI 4.1–8.2) times higher than in POC users. Among CHC users, 10.3% had more than one risk factor for thrombosis. In regards to the risk of thromboembolism, wider use of POCs and declining prevalence of CHCs in Estonia is positive trend. Still, women with history of thrombosis receiving CHC is a serious concern.
The shape of the universe and it's density parameter; the ratio of the actual density of the universe to the critical density that would be required to cause the expansion to stop
Creators: name: Aly, Islam Atef
Publisher: name: figshare
Year: 2017
Subjects: Astrophysics
Cosmology
Space Science
Stellar Astronomy

description: This paper overviewing the answer to a reasonable question to wonder what the shape of the Universe is. Is it a sphere? A torus? Is it open or closed, or flat? And what does that all mean anyway? Is it doubly curved like a western saddle? What can determine the entire fate of the Universe. Does the Universe go on forever? If not is there some kind of giant brick wall at the edge of the Universe? As it turns out, the answer is both simpler and weirder than all those options. What does the Universe look like is a question we love to guess at as a species and make up all kinds of nonsense.
Additional file 1 of Influence of the interaction between parental myopia and poor eye habits when reading and writing and poor reading posture on prevalence of myopia in school students in Urumqi, China
Creators: name: Shi, Haonan
name: Fu, Jing
name: Liu, Xiaojing
name: Wang, Yingxia
name: Yong, Xianting
name: Jiang, Lan
name: Ma, Shaowei
name: Yin, Zhe
name: Yao, Jian
name: Yao, Xuan
name: Chen, Xueyi
name: Wang, Tingting
Publisher: name: figshare
Year: 2021
Subjects: Space Science
Medicine
Pharmacology
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1.
Supplementary Material for: Individual Characteristics and Physical Activity in Older Adults: A Systematic Review
Creators: name: Notthoff, N.
name: Reisch, P.
name: Gerstorf, D.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: People aged 50 years and older are regularly identified as the most sedentary group in the population. However, even within this group, there are considerable interindividual variations in physical activity (PA) levels. They have been the subject of many studies. Based on single studies, no clear picture as to which characteristics are important has emerged. Objective: The goal of our contribution was to identify which individual characteristics are consistently linked to high PA levels in older adults. Methods: We conducted a systematic review of the literature considering demographic characteristics (gender, education, marital status, employment), health (subjective, health problems), and psychological factors (motivation, self-efficacy, locus of control). A systematic search of abstracts in the database Web of Science and a thorough screening process according to a priori specified criteria yielded 63 studies for inclusion in this review. Results: Two psychological factors - motivation and self-efficacy - and the perception of one's health seem to be consistently linked to higher PA levels in older adults. Selected demographic variables - gender and education - may be important for some types of PA. Conclusion: Our review suggests that differentiation of PA by domains is important for identifying and understanding which individual characteristics are associated with PA levels and how. Pinpointing what reliably distinguishes older adults who are active from those who are not is essential for designing effective interventions to promote PA in later life.
title: saint Cyr
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Martyr en 304, condamné à mort sous Dioclétien, à Antioche, avec sa mère sainte Julitte à l'âge de trois ans ; représenté chevauchant un sanglier ; attributs : une scie.
Additional file 1 of Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer
Creators: name: Li, Xinying
name: Chen, Cen
name: Wang, Zimu
name: Liu, Jiaxin
name: Sun, Wei
name: Shen, Kaikai
name: Lv, Yanling
name: Zhu, Suhua
name: Zhan, Ping
name: Lv, Tangfeng
name: Song, Yong
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 1: Figure S1: (A) and (B) particle size analysis of exosomes in the cell supernatant and plasma of patients, respectively. Figure S2: Pathway enrichment analysis of differentially expressed miRNA target genes. Figure S3. Differentially expressed exosome-derived miRNAs before and after osimertinib resistance. Figure S4. Exosome-derived miRNAs related to osimertinib resistance in patients with T790M mutation. Figure S5. Diagnostic value of exosomal miRNAs for NSCLC. Table S1. Exosomal miRNAs-induced osimertinib resistance by the activation of bypass pathways.
S3 Text.
Creators: name: Krystosik, Amy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: S3 Text. SVG Interview Footnotes. All SVG interviews were transcribed and translated. We used examples taken from these expert narratives throughout the paper to illustrate the various points being raised. CHW = community health worker, VC = vector control specialist. DOI: 10.6084/m9.figshare.5172970
Supplementary Material for: Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin Neurons
Creators: name: Mittelman-Smith, M.A.
name: Wong, A.M.
name: Micevych, P.E.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Positive feedback on gonadotropin release requires not only estrogen but also progesterone to activate neural circuits. In rodents, ovarian estradiol (E2) stimulates progesterone synthesis in hypothalamic astrocytes (neuroP), needed for the luteinizing hormone (LH) surge. Kisspeptin (kiss) neurons are the principal stimulators of gonadotropin-releasing hormone neurons, and disruption of kiss signaling abrogates the LH surge. Similarly, blocking steroid synthesis in the hypothalamus or deleting classical progesterone receptor (PGR) selectively in kiss neurons prevents the LH surge. These results suggest a synergistic action of E2 and progesterone in kiss neurons to affect gonadotropin release. The mHypoA51, immortalized kiss-expressing neuronal cell line derived from adult female mice, is a tractable model for examining integration of steroid signaling underlying estrogen positive feedback. Here, we report that kiss neurons in vitro integrate E2 and progesterone signaling to increase levels of kiss translation and release. mHypoA51 neurons expressed nonclassical membrane progesterone receptors (mPRα and mPRβ) and E2-inducible PGR, required for progesterone-augmentation of E2-induced kiss expression. With astrocyte-conditioned media or in mHypoA51-astrocyte co-culture, neuroP augmented stimulatory effects of E2 on kiss protein. Progesterone activation of classical, membrane-localized PGR led to activation of MAPK and Src kinases. Importantly, progesterone or Src activation induced release of kiss from E2-primed mHypoA51 neurons. Consistent with previous studies, the present results provide compelling evidence that the interaction of E2 and progesterone stimulates kiss expression and release. Further, these results demonstrate a mechanism though which peripheral E2 may prime kiss neurons to respond to neuroP, mediating estrogen positive feedback.
Additional file 1 of LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling
Creators: name: Zhu, Yuan
name: Zhang, Xiao
name: Gu, Ranli
name: Liu, Xuenan
name: Wang, Siyi
name: Xia, Dandan
name: Li, Zheng
name: Lian, Xiaomin
name: Zhang, Ping
name: Liu, Yunsong
name: Zhou, Yongsheng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Additional file 1: Table S1. Sequences of RNA and DNA oligonucleotides.
S3 Text. SVG Interview Footnotes.
Creators: name: Krystosik, Amy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: We used examples taken from expert narratives throughout the paper to illustrate the various points being raised (S3 Text. SVG Interview Footnotes).
S1 Text.
Creators: name: Krystosik, Amy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: S1 Text. Geonarrative Transcripts. All SVG interviews were transcribed in Spanish and translated from Spanish to English by Fluent and Native speakers. DOI: 10.6084/m9.figshare.5172502
Spatial Video Geonnarative Data
Creators: name: Krystosik, Amy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: S5 Data. Geonarrative Transcripts. All SVG interviews were transcribed in Spanish and translated from Spanish to English by Fluent and Native speakers.
Folders A, B, C, and D in S4 Data. Shape files. Shapefiles were used to define the neighborhoods, communas, rivers, health centers, and urban boundaries.
Creators: name: Krystosik, Amy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Geography
subject: 160403 Social and Cultural Geography
subject: FOS: Social and economic geography

description: Folders A and files 1, 2, and 3 in S1 Data. Case data aggregated to neighborhood level. All cases were mapped to the neighborhood level. Folders B in S1 Data. Shape files. Shapefiles were used to define the neighborhoods, communas, rivers, health centers, and urban boundaries. 
GEOGRAPHICAL COUPLING OF THE LOCATION’S ACTIVITY IN CYBERSPACE AND AGGLOMERATION OF BUSINESS SERVICE ENTERPRISES
Creators: name: Wu, Jian
name: Qian, Sheng
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 460199
subject: Applied computing not elsewhere classified

description: Cyberspace is the new geographical space formed in the virtual digital world which is different from the traditional geographical system. There are some debates that whether Cyberspace lead to further spatial divergence of economic activities or not. Based on existing related research achievements this paper studies the Cyberspace’s influence on the spatial distribution of business services, puts forward some hypothesizes about the relationship between the Cyberspace active location and the agglomeration of business services enterprises. By some empirical method, it measures the spatial coupling of location’s activity in Cyberspace and the business service enterprises’ agglomeration, and the econometric model is established to test the hypotheses. It finds that there is a high coupling relationship of location’s Cyberspace activity degree and spatial agglomeration of business services.
Study on foam extinguishing agent based on mixed system of branched short-chain fluorocarbon anionic and hydrocarbon cationic surfactants
Creators: name: Yang, Yawen
name: Fang, Jiaqing
name: Sha, Min
name: Zhang, Ding
name: Pan, Renming
name: Jiang, Biao
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology

description: The traditional aqueous film-forming foam extinguishing agent (AFFF) plays an important role in fighting liquid fires, but its environmental hazard are also increasingly prominent. The key component of conventional AFFF is fluorocarbon surfactant containing perfluorinated C8 segment, which is one of the most refractory organic pollutants in the world. In this paper, a perfluorinated branched short-chain alkyl side chain fluorocarbon anionic surfactant with high surface activity and simple synthesis route was prepared. The surface activity and aggregation behavior of the mixed solution of fluorocarbon and hydrocarbon surfactants were studied by surface tension meter and transmission electron microscope (TEM). When the mixture ratio of fluorocarbon and hydrocarbon surfactant reached 1:10, the addition of cetyltrimethylammonium bromide (CTAB) had little effect on the interfacial adsorption, but could significantly reduce the critical micelle concentration (CMC) of fluorocarbon surfactant. Meanwhile, three kinds of environment-friendly AFFF formulations (F-1, F-2, F-3) were designed with the mixed system of different hydrocarbon surfactants and this fluorocarbon anionic surfactant as foaming agents. The foam properties revealed the F-2 possessed excellent foam performance, the initial foam height h0 was 120 mm, and the 25% drainage time was 240 s, extinguishing time was 30 s, burn-back time was 760 s.
title: Slippix – der Schleifstab
title: Didaktische Hinweise zur Fertigung des Schleifstabs Slippix
titleType: Subtitle
Creators: name: Penning, Isabelle
name: Gulich, Riccardo
name: Glugla, Markus
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 370 Bildung und Erziehung

description: Lehrkräfte sind mit Blick auf ihre heterogenen Lerngruppen im Technikunterricht darauf angewiesen, einen differenzierten Unterricht zu gestalten, der personelle, organisatorische und sachliche Ressourcen miteinbezieht. Bei Fertigungsaufgaben bietet sich daher der Einsatz von Vorrichtungen an, über die auf die unterschiedlichen Lernvoraussetzungen von Schüler:innen reagiert werden kann. So lassen sich die Anforderungen von Fertigungsaufgaben gezielt variieren. 
Die vorliegende Publikation beschreibt den Schleifstab „Slippix“, der für jegliche Schleifarbeiten an Ecken, Kanten und Flächen verwendet werden kann, bei denen das Werkstück fest eingespannt ist. Ähnlich wie beim Arbeiten mit einer Holzfeile, wird bei „Slippix“ die gesamte Länge des Stabs genutzt und über das Holz geführt. Slippix ermöglicht jedoch die Anpassung der Körnungen. „Slippix“ ist in drei Versionen herstellbar. Neben der Standardversion (ohne Handgriffe), gibt es noch Versionen mit Handgriffen und mit einem Haltesteg. Die einzelnen Versionen unterscheiden sich zum Teil in ihren Maßen.
Die Dokumentationen umfasst neben den Fertigungsunterlagen kleinschrittige Bauanleitungen, die ggf. auch gemeinsam mit Schüler:innen umgesetzt werden können. Zudem enthalten sind beispielhafte Kostenrechnungen sowie Schablonen, die zur Erleichterung des Fertigungsprozesses verwendet werden können. Des Weiteren wird durch vereinzelt beigefügte interaktive technische Zeichnungen die Adaption der Vorrichtungen ermöglicht.
Additional file 1 of LncRNA PTCSC3 is upregulated in osteoporosis and negatively regulates osteoblast apoptosis
Creators: name: Liu, Xingchao
name: Chen, Mingliang
name: Liu, Qinghe
name: Li, Gang
name: Yang, Pei
name: Zhang, Guodong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 1. Supplemental Figure 1. Our preliminary deep sequencing analysis revealed altered PTCSC3 expression in osteoporosis. T: osteoporosis groups; ***, p < 0.001. Supplemental Figure 2. RT-PCR detection of PTCSC3 in medium of osteoblasts and fresh medium.
“The Use of Olanzapine compared to Aprepitant as antiemetic for prevention of chemotherapy induced nausea and vomiting in highly emetogenic chemotherapy -A Randomized Trial.”
Creators: name: Simit Sapkota
name: Pandit, Subhash
name: Mahaseth, Rita
name: Jha, Krishna
Publisher: name: figshare
Year: 2017
Subjects: Medicine

description: Chemotherapy induced nausea and vomiting (CINV) is still major problem in oncology. Though new antiemetic drug have markedly reduced incidence of CINV those who experience it have poor quality of life. NK1 receptor antagonist(Aprepitant or Fosparitant), 5HT3 receptor antagonist and dexamethasone combination are recommended for highly emetogenic chemotherapy. Though alternative drugs are tried only olanzapine had showed some potential as standard antiemetic therapy and has been used in addition to standard therapy or replacing NK1 receptor antagonist. In developing country like Nepal NK1 receptor is not freely available and expensive as well so sometimes clinicians have to prescribe substandard antiemetic therapy (5HT3 receptor antagonist and dexamethasone only). This study was done to check if Olanzapine have similar efficacy as NK1 receptor antagonist so we can replace it with freely available, cheaper alternative. The results are encouraging and future studies will help to establish olanzapine as equally effective alternative to NK1 receptor antagonist.
Spatial Video Geonnarative Data
Creators: name: Krystosik, Amy
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: S1 Text. Geonarrative Transcripts. All SVG interviews were transcribed in Spanish and translated from Spanish to English by Fluent and Native speakers. DOI: 10.6084/m9.figshare.5172502