Additional file 1 of Bacteria and sputum inflammatory cell counts; a COPD cohort analysis
Creators: name: Beech, Augusta S.
name: Lea, Simon
name: Kolsum, Umme
name: Wang, Zhang
name: Miller, Bruce E.
name: Donaldson, Gavin C.
name: Wedzicha, Jadwiga A.
name: Brightling, Christopher E.
name: Singh, Dave
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Flow chart of subject selection process. Figure S2. The comparison of Blood Lymphocyte counts between patients colonised with different PPMs at 6 months post-baseline. Figure S3. The comparison of sputum and blood eosinophil and neutrophil counts between patients colonised with different PPMs. Figure S4. The comparison of sputum and blood eosinophil and neutrophil counts between patients colonised with different PPMs at 6 months post-baseline. Figure S5. Sputum microbiome profiles in COPD patients at 6 months. Figure S6. Stability of Haemophilus presence over 6 months as defined by 16s rRNA Sequencing. Table S1. Composition of &gt; 1PPM group at baseline. Table S2. Sputum inflammatory cell counts and qPCR for patients with frequent or infrequent exacerbations in the 12 months prior to baseline. Table S3. Baseline sputum inflammatory cell counts for induced versus spontaneous sputum samples. Table S4. Baseline sputum inflammatory cell counts for different PPM groups. Table S5. Baseline Demographics of patients enrolled onto this study for different PPM groups. Table S6. Baseline blood inflammatory cell counts for different PPM groups. Table S7. Sputum inflammatory cell counts for different PPM groups at 6 months. Table S8. Blood inflammatory cell counts for different PPM groups at 6 months. Table S9. Baseline sputum inflammatory cell counts for different PPM groups, × 106 copies/ml to detect PPMs. Table S10. Baseline blood inflammatory cell counts for different PPM groups, × 106 copies/ml to detect PPMs. Table S11. Sputum inflammatory cell counts for different PPM groups at 6 months, × 106 copies/ml to detect PPMs. Table S12. Blood inflammatory cell counts for different PPM groups at 6 months, × 106 copies/ml to detect PPMs. Table S13. Baseline demographics, sputum and blood inflammatory cell counts for different PPM groups, × 106 copies/ml to detect PPMs. Table S14. Baseline demographics for different PPM groups. Table S15. Sputum and blood inflammatory cell counts for different PPM groups. Table S16. Baseline demographics for different PPM groups, including those with H. influenzae + ≥ 1 PPM. Table S17. Baseline sputum inflammatory cell counts for different PPM groups, including those with H.influenzae + ≥ 1 PPM. Table S18. Occurrence and average relative abundance of contaminate genera detected in sequenced negative ‘blank’ controls by Salter et al. [5] in the COPDMAP dataset.