cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Infection of porcine enteroids and 2D differentiated intestinal epithelial cells with rotavirus A to study cell tropism and polarized immune response
Creators: name: Yan, Miaomiao
name: Su, Ang
name: Pavasutthipaisit, Suvarin
name: Spriewald, Rebecca
name: Grassl, Guntram A.
name: Beineke, Andreas
name: Hoeltig, Doris
name: Herrler, Georg
name: Becher, Paul
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Rotavirus A
subject: enteroids
subject: enterocytes
subject: goblet cells
subject: Paneth cells
subject: innate immunity
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Intestinal epithelial cell interactions with enteric pathogens have been incompletely elucidated owing to the lack of model systems that recapitulate the cellular diversity, architecture and functionality of the intestine. To analyze rotavirus (RV) infection and the subsequent innate immune response, we established cultures of differentiated porcine intestinal epithelial cells in three different variations: basolateral-out enteroids, apical-out enteroids and two-dimensional (2D) filter-grown intestinal epithelial cells. Application of specific antibodies for fluorescent staining indicated that enteroids and enteroid-derived cell cultures contain multiple intestinal epithelial cell types. Infection studies indicated that both apical-out enteroids and 2D intestinal epithelial cells are susceptible to porcine RV infection. However, 2D intestinal epithelial cells are more useful for a detailed characterization and comparison of apical and basolateral infection than apical-out enteroids. Virus-induced apoptosis was observed in apical-out enteroids at 24 h post infection but not at earlier time points after infection. RV infected not only enterocytes but also goblet cells and Paneth cells in apical-out enteroids and 2D intestinal epithelial cells. Interestingly, despite the lack of significant differences in the efficiency of infection after apical and basolateral infection of 2D intestinal epithelial cells, stronger innate immune and inflammatory responses were observed after basolateral infection as compared to infection via the apical route. Therefore, apical-out enteroids and 2D intestinal epithelial cells provide useful primary cell culture models that can be extended to analyze invasion and replication strategies of agents implicated in enteric diseases or to study immune and inflammatory responses of the host induced by enteric pathogens.
Gamma-ray free-electron lasers: Quantum fluid model
Creators: name: Silva, H. M.
name: Serbeto, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: A quantum fluid model is used to describe the interacion of a nondegenerate cold relativistic electron beam with an intense optical wiggler taking into account the beam space-charge potential and photon recoil effect. A nonlinear set of coupled equations are obtained and solved numerically. The numerical results shows that in the limit of plasma wave-breaking an ultra-high power radiation pulse are emitted at the$γ$-ray wavelength range which can reach an output intensity near the Schwinger limit depending of the values of the FEL parameters such as detuning and input signal initial phase at the entrance of the interaction region.
description: This paper has been withdrawn by the author due to we are changing the parameters used to make a more realistic analysis, from the experimental point of view
Endorsement of: Roman A. Montero, Jesus's Manifesto: The Sermon on the Plain (April 2019, Wipf and Stock Publishers)
Creators: name: Vasileiadis, Pavlos D.
Publisher: name: Zenodo
Year: 2019
Subjects: Παύλος Βασιλειάδης
Pavlos Vasileiadis
New Testament
Roman Montero

description: https://www.amazon.com/Jesuss-Manifesto-Sermon-Roman-Montero/dp/1532676034
The convergence between Computing and Astronomy:the case of the Space Weather forecasting
Creators: name: Gradvohl, Andre Leon Sampaio
Publisher: name: Zenodo
Year: 2018
Subjects: Space Weather
Forecasting
Neural Networks
Deep Learning
Data Stream Mining
Astronomy

description: This presentation defines what Space Weather is and discusses some computational techniques for Space Weather forecasting, such as Neural Networks, Deep Learning, Data Stream Mining. In addition, it proposes some research fronts to be explored in the short term.
Archiv der Staatsbibliothek, Berlin
Creators: name: Giltaij, Jacob
Publisher: name: Zenodo
Year: 2018
Subjects: Fritz Schulz
Franz Wieacker
Helmut Coing

description: Archival notes from Archiv der Staatsbibliothek zu Berlin, Haus am Postdamerstrasse, Handschriftenabteilung, Berlin. Schulz Verlagsverträge NL 488, A 367,1: Contracts between Fritz Schulz and Mohr Siebeck publishing house. Wieacker Verlagsverträge NL 488, B. 1,2 M.23: Contract between Franz Wieacker and Mohr Siebeck publishing house. Coing Verlagsverträge NL 488, B 1.1 M.6: Contracts between Helmut Coing and Mohr Siebeck publishing house.
Paranoid Transformer: Reading Narrative of Madness as Computational Approach to Creativity
Creators: name: Agafonova, Yana
name: Tikhonov, Alexey
name: Yamshchikov, Ivan P.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: H.1.2; J.5; K.4
subject: 68T50, 68T07, 91F20, 68T42

description: This papers revisits the receptive theory in context of computational creativity. It presents a case study of a Paranoid Transformer - a fully autonomous text generation engine with raw output that could be read as the narrative of a mad digital persona without any additional human post-filtering. We describe technical details of the generative system, provide examples of output and discuss the impact of receptive theory, chance discovery and simulation of fringe mental state on the understanding of computational creativity.
Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota
Creators: name: Foote, Minnja S.
name: Du, Ke
name: Mousavi, Soraya
name: Bereswill, Stefan
name: Heimesaat, Markus M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: carvacrol
subject: enteropathogenic infection
subject: Campylobacter jejuni
subject: immune-modulatory effects
subject: human-gut-microbiota-associated IL-10(- /-) mice
subject: campylobacteriosis model
subject: host-pathogen interaction
subject: placebo-controlled preclinical intervention study
subject: One Health concept
subject: food safety
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Human Campylobacter jejuni infections are rising globally. Since antibiotics are usually not indicated in acute campylobacteriosis, antibiotic-independent intervention measures are desirable. The phenolic compound carvacrol constitutes a promising candidate molecule given its antimicrobial and immune-modulatory features. To test the disease-alleviating effects of oral carvacrol treatment in acute murine campylobacteriosis, IL-10(-/-) mice harboring a human gut microbiota were perorally infected with C. jejuni and treated with carvacrol via the drinking water. Whereas C. jejuni stably established in the gastrointestinal tract of mice from the placebo cohort, carvacrol treatment resulted in lower pathogen loads in the small intestines on day 6 post infection. When compared to placebo, carvacrol ameliorated pathogen-induced symptoms including bloody diarrhea that was accompanied by less distinct histopathological and apoptotic cell responses in the colon. Furthermore, innate and adaptive immune cell numbers were lower in the colon of carvacrol- versus placebo-treated mice. Notably, carvacrol application dampened C. jejuni-induced secretion of pro-inflammatory mediators in intestinal, extra-intestinal and systemic organs to naive levels and furthermore, resulted in distinct shifts in the fecal microbiota composition. In conclusion, our preclinical placebo-controlled intervention study provides evidence that therapeutic carvacrol application constitutes a promising option to alleviate campylobacteriosis in the infected vertebrate host.
Machine learning thermal circuit network model for thermal design optimization of electronic circuit board layout with transient heating chips
Creators: name: Otaki, Daiki
name: Nonaka, Hirofumi
name: Yamada, Noboru
Publisher: name: arXiv
Year: 2020
Subjects: subject: Applied Physics (physics.app-ph)
subject: Machine Learning (cs.LG)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: J.6

description: This paper describes a method combining Bayesian optimization (BO) and a lamped-capacitance thermal circuit network model that is effective for speeding up the thermal design optimization of an electronic circuit board layout with transient heating chips. As electronic devices have become smaller and more complex, the importance of thermal design optimization to ensure heat dissipation performance has increased. However, such thermal design optimization is difficult because it is necessary to consider various trade-offs associated with packaging and transient temperature changes of heat-generating components. This study aims to improve the performance of thermal design optimization by artificial intelligence. BO using a Gaussian process was combined with the lamped-capacitance thermal circuit network model, and its performance was verified by case studies. As a result, BO successfully found the ideal circuit board layout as well as particle swarm optimization (PSO) and genetic algorithm (GA) could. The CPU time for BO was 1/5 and 1/4 of that for PSO and GA, respectively. In addition, BO found a non-intuitive optimal solution in approximately 7 minutes from 10 million layout patterns. It was estimated that this was 1/1000 of the CPU time required for analyzing all layout patterns.
description: 13 pages, 7 figures
Leipzig Universitätsarchiv, Leipzig
Creators: name: Erkkilä, Ville
Publisher: name: Zenodo
Year: 2018
Subjects: Franz Wieacker
Paul Koschaker
Gerald Wiemers
Hans-Georg Gadamer
Jacob Neubauer

description: Archival notes from Leipzig Universitätsarchiv, Leipzig. Personenakten Koschaker, Paul, PA-SG 1277: Jacob Neubauer’s letter to Paul Koschaker. Personenakten Wieacker, Franz, PA-SG 0457: Letters between Franz Wieacker and Gerald Wiemers, newspaper articles on Wieacker’s birthdays and finally death, H.-G. Gadamer’s approval that Wieacker was not a Nazi, a workorder in 1944 from Reichminister für Wissenschaft, Erziehung und Volksbild, and Wieacker’s list of the places and persons abroad he has visited or at least has been in contact with during the war. Personenakten Koschaker, Paul, PA-4064: Leipzig University’s inquiry for its workers whether they are Austrian citizens. Four answers (including Koschaker’s).
UltraFuzz: Towards Resource-saving in Distributed Fuzzing
Creators: name: Zhou, Xu
name: Wang, Pengfei
name: Liu, Chenyifan
name: Yue, Tai
name: Liu, Yingying
name: Song, Congxi
name: Lu, Kai
name: Yin, Qidi
name: Han, Xu
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Recent research has sought to improve fuzzing performance via parallel computing. However, researchers focus on improving efficiency while ignoring the increasing cost of testing resources. Parallel fuzzing in the distributed environment amplifies the resource-wasting problem caused by the random nature of fuzzing. In the parallel mode, owing to the lack of an appropriate task dispatching scheme and timely fuzzing status synchronization among different fuzzing instances, task conflicts and workload imbalance occur, making the resource-wasting problem severe. In this paper, we design UltraFuzz, a fuzzer for resource-saving in distributed fuzzing. Based on centralized dynamic scheduling, UltraFuzz can dispatch tasks and schedule power globally and reasonably to avoid resource-wasting. Besides, UltraFuzz can elastically allocate computing power for fuzzing and seed evaluation, thereby avoiding the potential bottleneck of seed evaluation that blocks the fuzzing process. UltraFuzz was evaluated using real-world programs, and the results show that with the same testing resource, UltraFuzz outperforms state-of-the-art tools, such as AFL, AFL-P, PAFL, and EnFuzz. Most importantly, the experiment reveals certain results that seem counter-intuitive, namely that parallel fuzzing can achieve ``super-linear acceleration'' when compared with single-core fuzzing. We conduct additional experiments to reveal the deep reasons behind this phenomenon and dig deep into the inherent advantages of parallel fuzzing over serial fuzzing, including the global optimization of seed energy scheduling and the escape of local optimal seed. Additionally, 24 real-world vulnerabilities were discovered using UltraFuzz.
description: 22 pages, 8 figures
SCALABLE - D7.3 Intermediate assessment report on Exploitation, Communication and Dissemination
Creators: name: Germetz, Emilie
Publisher: name: Zenodo
Year: 2022

description: This deliverable titled “Intermediate assessment report on Exploitation, Communication and Dissemination”, while offering a reminder on the SCALABLE dissemination strategy, outlines the work carried out in Work Package 7 (WP7) during the first half of the project (i.e. covering the period between January 2021 and June 2022). During this period, the consortium has succeeded in designing the project's identity and first materials, developing its online presence, through its website and social networks, where it continues to grow and share with the identified communities. The partners also participated in key events of the ecosystem in which SCALABLE operates, during which they were able to interact directly with the communities interested in its use cases, and to present the first developments of the project on booths or through posters. For the second half of the project, WP7 will focus intensively on promoting project results through a variety of channels , notably by adding new content to its project website, using said new content to create a project flyer to be distributed at events and displayed on the project website and shared in partners’ networks, and by contuning to join ecosystem events through submitted talks and/or posters as well as at partners’ booths. A particular effort will also be put to reach SCALABLE key target audiences and, in particular, scientific and industrial communities that may be interested by the project’s results.
New Constraints on the Faint-end of the UV Luminosity Function at z~7-8 using the Gravitational Lensing of the Hubble Frontier Fields Cluster A2744
Creators: name: Atek, Hakim
name: Richard, Johan
name: Kneib, Jean-Paul
name: Jauzac, Mathilde
name: Schaerer, Daniel
name: Clement, Benjamin
name: Limousin, Marceau
name: Jullo, Eric
name: Natarajan, Priyamvada
name: Egami, Eiichi
name: Ebeling, Harald
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Exploiting the power of gravitational lensing, the Hubble Frontier Fields (HFF) program aims at observing six massive galaxy clusters to explore the distant Universe far beyond the depth limits of blank field surveys. Using the complete Hubble Space Telescope observations of the first HFF cluster Abell 2744, we report the detection of 50 galaxy candidates at $z \sim 7$ and eight candidates at $z \sim 8$ in a total survey area of 0.96 arcmin$^{2}$ in the source plane. Three of these galaxies are multiply-imaged by the lensing cluster. Using an updated model of the mass distribution in the cluster we were able to calculate the magnification factor and the effective survey volume for each galaxy in order to compute the ultraviolet galaxy luminosity function at both redshifts 7 and 8. Our new measurements extend the $z \sim 7$ UV LF down to an absolute magnitude of $M_{UV} \sim -15.5$. We find a characteristic magnitude of $M^{\star}_{UV}=-20.63^{+0.69}_{-0.56}$ mag and a faint-end slope $α= -1.88^{+0.17}_{-0.20}$ close to previous determinations in blank fields. We show here for the first time that this slope remains steep down to very faint luminosities of 0.01$L^{\star}$. Although prone to large uncertainties, our results at $z \sim 8$ also seem to confirm a steep faint-end slope below 0.1$L^{\star}$. The HFF program is therefore providing an extremely efficient way to study the faintest galaxy populations at $z > 7$ that would otherwise be inaccessible with current instrumentation. The full sample of six galaxy clusters will provide yet better constraints on the build-up of galaxies at early epochs and their contribution to cosmic reionization.
description: 14 pages, 9 figures, submitted to ApJ
HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat
Creators: name: Eron, J. J.
name: Bateson, R.
name: Richman, D. D.
name: Anderson, E. M.
name: Margolis, D. M.
name: Bosch, R. J.
name: Kearney, M. F.
name: Kuruc, J. D.
name: Robertson, K. R.
name: Coffin, J. M.
name: Strain, M. C.
name: Hazuda, D. J.
name: Crooks, A. M.
name: Tripathy, M. K.
name: Kashuba, A. D.
name: Archin, N. M.
name: Dahl, N. P.
name: Yang, K.-H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human immunodeficiency virus (HIV)–positive participants. The ability of multiple exposures to VOR to repeatedly disrupt latency has not been directly measured, to our knowledge.
The New School Archives and Special Collections, New York
Creators: name: Giltaij, Jacob
Publisher: name: Zenodo
Year: 2018
Subjects: Hermann Kantorowicz

description: Archival notes from The New School Archives and Special Collections (former The New School for Social Research), New York. The New School Graduate Faculty minutes, NS.02.17.02: The Faculty minutes of the Faculty of Political and Social Science of the New School, also known as the 'University in Exile'.
Classifiers fusion method to recognize handwritten persian numerals
Creators: name: Azad, Reza
name: Azad, Babak
name: Mogharreb, Iraj
name: Jamali, Shahram
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Recognition of Persian handwritten characters has been considered as a significant field of research for the last few years under pattern analysing technique. In this paper, a new approach for robust handwritten Persian numerals recognition using strong feature set and a classifier fusion method is scrutinized to increase the recognition percentage. For implementing the classifier fusion technique, we have considered k nearest neighbour (KNN), linear classifier (LC) and support vector machine (SVM) classifiers. The innovation of this tactic is to attain better precision with few features using classifier fusion method. For evaluation of the proposed method we considered a Persian numerals database with 20,000 handwritten samples. Spending 15,000 samples for training stage, we verified our technique on other 5,000 samples, and the correct recognition ratio achieved approximately 99.90%. Additional, we got 99.97% exactness using four-fold cross validation procedure on 20,000 databases.
description: This paper has been withdrawn by the author due to a crucial sign error in equation 5 and 6, and some mistake in Table 1 information. please let me for changing this information and updating this paper
Asymptotic Performance Prediction for ADMM-Based Compressed Sensing
Creators: name: Hayakawa, Ryo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Signal Processing (eess.SP)
subject: Information Theory (cs.IT)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: In this paper, we propose a method to predict the asymptotic performance of the alternating direction method of multipliers (ADMM) for compressed sensing, where we reconstruct an unknown structured signal from its underdetermined linear measurements. The derivation of the proposed method is based on the recently developed convex Gaussian min-max theorem (CGMT), which can be applied to various convex optimization problems to obtain its asymptotic error performance. Our main idea is to analyze the convex subproblem in the update of ADMM iteratively and characterize the asymptotic distribution of the tentative estimate obtained at each iteration. However, since the original CGMT cannot be used directly for the analysis of the iterative updates, we intuitively assume an extended version of CGMT in the derivation of the proposed method. Under the assumption, the result shows that the update equations in ADMM can be decoupled into a scalar-valued stochastic process in the asymptotic regime with the large system limit. From the asymptotic result, we can predict the evolution of the error (e.g., mean-square-error (MSE) and symbol error rate (SER)) in ADMM for large-scale compressed sensing problems. Simulation results show that the empirical performance of ADMM and its prediction are close to each other in sparse vector reconstruction and binary vector reconstruction.
description: accepted to IEEE Transactions on Signal Processing
Collective variables between large-scale states in turbulent convection
Creators: name: Maity, Priyanka
name: Bittracher, Andreas
name: Koltai, Péter
name: Schumacher, Jörg
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Convection
subject: Turbulence
subject: Nonlinear Dynamics
subject: Fluid Dynamics
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: The dynamics in a confined turbulent convection flow is dominated by multiple long-lived macroscopic circulation states that are visited subsequently by the system in a Markov-type hopping process. In the present work, we analyze the short transition paths between these subsequent macroscopic system states by a data-driven learning algorithm that extracts the low-dimensional transition manifold and the related new coordinates, which we term collective variables, in the state space of the complex turbulent flow. We therefore transfer and extend concepts for conformation transitions in stochastic microscopic systems, such as in the dynamics of macromolecules, to a deterministic macroscopic flow. Our analysis is based on long-term direct numerical simulation trajectories of turbulent convection in a closed cubic cell at a Prandtl number Pr=0.7 and Rayleigh numbers Ra=106 and 107 for a time lag of 105 convective free-fall time units. The simulations resolve vortices and plumes of all physically relevant scales, resulting in a state space spanned by more than 3.5 million degrees of freedom. The transition dynamics between the large-scale circulation states can be captured by the transition manifold analysis with only two collective variables, which implies a reduction of the data dimension by a factor of more than a million. Our method demonstrates that cessations and subsequent reversals of the large-scale flow are unlikely in the present setup, and thus it paves the way for the development of efficient reduced-order models of the macroscopic complex nonlinear dynamical system.
Prevalence of Hepatitis C Virus Infection in US Hispanic/Latino Adults: Results From the NHANES 2007–2010 and HCHS/SOL Studies
Creators: name: Thyagarajan, Bharat
name: Kim, Ryung S.
name: Heiss, Gerardo
name: Jung, Molly
name: Ho, Gloria Y. F.
name: Youngblood, Marston
name: Kaplan, Robert C.
name: Cotler, Scott
name: Everhart, James E.
name: Strickler, Howard D.
name: McQuillan, Geraldine
name: Kuniholm, Mark H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Prevalence of hepatitis C virus (HCV) antibody has been reported in Mexican Americans, but its prevalence in other US Hispanic/Latino groups is unknown. We studied 2 populations of US Hispanic/Latino adults; 3210 from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 and 11 964 from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Age-standardized prevalence of HCV antibody was similar in NHANES 2007–2010 (1.5%) and HCHS/SOL (2.0%) but differed significantly by Hispanic/Latino background in HCHS/SOL (eg, 11.6% in Puerto Rican men vs 0.4% in South American men). These findings suggest that the HCV epidemic among US Hispanics/Latinos is heterogeneous.
Individual project on theme "Apis Linnaeus" (MOOC: CompTech in biology)
Creators: name: Gayvoronskiy Sergey
Publisher: name: Zenodo
Year: 2023

description: Данный кейс является результатом реализации индивидуального проекта Гайворонского Сергея по теме "Apis Linnaeus" в рамках онлайн курса "Компьютерные технологии в биологии" (автор – А.В. Ваганов) (https://stepik.org/course/60859/promo)
Transmission Amplitude through a Coulomb blockaded Majorana Wire
Creators: name: Thamm, Matthias
name: Rosenow, Bernd
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study coherent electronic transport through a Coulomb blockaded superconducting Rashba wire in the co-tunneling regime between conductance resonances. By varying an external Zeeman field the wire can be tuned into a topological regime, where non-local transport through Majorana zero modes is the dominant mechanism. We model coherent transport in the co-tunneling regime by using a scattering matrix formalism, and find that the transmission amplitude has a maximum as a function of Zeeman field, whose height is proportional to the wire length. We relate the transmission amplitude to the Majorana correlation length, and argue that the Zeeman field and length dependence of the transmission amplitude are unique signatures for the presence of Majorana zero modes.
description: 14 pages, 11 figures, updated version
Para-Sasakian geometry in thermodynamic fluctuation theory
Creators: name: Bravetti, A.
name: Lopez-Monsalvo, C. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this work we tie concepts derived from statistical mechanics, information theory and contact Riemannian geometry within a single consistent formalism for thermodynamic fluctuation theory. We derive the concrete relations characterizing the geometry of the Thermodynamic Phase Space stemming from the relative entropy and the Fisher-Rao information matrix. In particular, we show that the Thermodynamic Phase Space is endowed with a natural para-contact pseudo-Riemannian structure derived from a statistical moment expansion which is para-Sasaki and η-Einstein. Moreover, we prove that such manifold is locally isomorphic to the hyperbolic Heisenberg group. In this way we show that the hyperbolic geometry and the Heisenberg commutation relations on the phase space naturally emerge from classical statistical mechanics. Finally, we argue on the possible implications of our results.
description: Significant improvements and corrections from the previous version. Additional material added
Regulatory T Cells Prevent Liver Fibrosis During HIV Type 1 Infection in a Humanized Mouse Model
Creators: name: Nunoya, Jun-ichi
name: Su, Lishan
name: Kovalev, Grigoriy I.
name: Washburn, Michael L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis associated with hepatic stellate cell activation, hepatitis, and liver injury. Our findings provide new insight linking Treg cells and liver immunopathogenesis during HIV-1 infection.
Juristische Bibliothek, Universität Bern, Bern
Creators: name: Beggio, Tommaso
Publisher: name: Zenodo
Year: 2018
Subjects: Paul Koschaker

description: Archival notes from Juristische Bibliothek (JBB), Universität Bern, Switzerland. JBB 5.020/148: An unpublished textbook (Lehrbuch) on Roman law by Paul Koschaker.
Women’s sexually transmitted infections in primary care: General practitioners’ challenges and strategies – A qualitative study in Germany
Creators: name: Meurer, Pauline
name: Heintze, Christoph
name: Schuster, Angela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: STI
subject: women's health
subject: primary health care
subject: general practice
subject: Germany
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The incidence of sexually transmitted infections (STI) is rising. Amongst women, STIs are often asymptomatic and thus likely underreported. STI care in Germany is fragmented. General Practitioners (GPs) could offer accessible care; however, to which extent GPs provide STI care and which challenges they face remains unclear. Objectives: To increase understanding of how GPs provide STI care for women in German high-incidence settings and to identify challenges and opportunities for improved care. Methods: Between 10/20 and 09/21, we contacted 75 practices using snowball and theoretical sampling. We conducted qualitative guide-assisted interviews with 19 GPs in their practices in Berlin, Germany. Data were analysed using thematic analysis with grounded theory components. Results: Responsibilities and financing of STI care services were unclear. Most GPs perceived specialised doctors to be responsible for STI care in women; however, many non-STI specialised doctors were the first point of contact for patients and felt responsible to help. (LBTQI) Women were perceived to have less access to care. Stigmatising perceptions of women with STI-related needs were common. Doctors immediately referred patients to other providers, offered STI care for selected cases, or routinely offered primary STI care. GPs' referral strategies were often unsystematic. Those who offered primary STI care perceived patients' need for STI care, showed open attitudes to sexual health, and had undergone further training on STI care. Conclusion: Training regarding STI care, remuneration, and referral pathways should be provided for GPs. Comprehensive STI care could be offered through the cooperation of GPs and specialists.
Semi-abelian analogues of Schanuel Conjecture and applications
Creators: name: Bertolin, Cristiana
name: Philippon, Patrice
name: Saha, Biswajyoti
name: Saha, Ekata
Publisher: name: arXiv
Year: 2020
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: In this article we study Semi-abelian analogues of Schanuel conjecture. As showed by the first author, Schanuel Conjecture is equivalent to the Generalized Period Conjecture applied to 1-motives without abelian part. Extending her methods, the second, the third and the fourth authors have introduced the Abelian analogue of Schanuel Conjecture as the Generalized Period Conjecture applied to 1-motives without toric part. As a first result of this paper, we define the Semi-abelian analogue of Schanuel Conjecture as the Generalized Period Conjecture applied to 1-motives. C. Cheng et al. proved that Schanuel conjecture implies the algebraic independence of the values of the iterated exponential and the values of the iterated logarithm, answering a question of M. Waldschmidt. The second, the third and the fourth authors have investigated a similar question in the setup of abelian varieties: the Weak Abelian Schanuel conjecture implies the algebraic independence of the values of the iterated abelian exponential and the values of an iterated generalized abelian logarithm. The main result of this paper is that a Relative Semi-abelian conjecture implies the algebraic independence of the values of the iterated semi-abelian exponential and the values of an iterated generalized semi-abelian logarithm.
Safety and Pharmacokinetics of Intravenous Zanamivir Treatment in Hospitalized Adults With Influenza: An Open-label, Multicenter, Single-Arm, Phase II Study
Creators: name: Thamlikitkul, V.
name: Man, C. Y.
name: Francois, B.
name: Yates, P. J.
name: Brealey, D.
name: Alvarez-Lerma, F.
name: van der Horst, C.
name: Garot, D.
name: Weller, S.
name: Manez, R.
name: Zhao, H. H.
name: Peppercorn, A. F.
name: Lorente, J. A.
name: Marty, F. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Background. Intravenous zanamivir is a neuraminidase inhibitor suitable for treatment of hospitalized patients with severe influenza.
Lipid nanoparticle-encapsulated, chemically modified anti-adenoviral siRNAs inhibit hepatic adenovirus infection in immunosuppressed Syrian hamsters
Creators: name: Geisler, Anja
name: Dieringer, Babette
name: Elsner, Leslie
name: Klingel, Karin
name: Klopfleisch, Robert
name: Vornlocher, Hans-Peter
name: Kurreck, Jens
name: Fechner, Henry
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: MT: Oligonucleotides: Therapies and applications
subject: adenovirus
subject: antiviral therapy
subject: siRNA
subject: lipid nanoparticles
subject: immunosuppressed Syrian hamsters
subject: hepatitis
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: RNA interference has demonstrated its potential as an antiviral therapy for treatment of human adenovirus (hAd) infections. The only existing viral vector-based system for delivery of anti-adenoviral artificial microRNAs available for in vivo use, however, has proven to be inefficient in therapeutic applications. In this study, we investigated the potential of stabilized small interfering RNA (siRNA) encapsulated in lipid nanoparticles (LNPs) for treatment of hepatic hAd serotype 5 (hAd5) infection in an hAd infection model using immunosuppressed Syrian hamsters. The siRNA sipTPmod directed against the adenoviral pre-terminal protein (pTP) and containing 2′-O-methyl modifications as well as phosphorothioate linkages effectively inhibited hAd5 infection in vitro. In light of this success, sipTPmod was encapsulated in LNPs containing the cationic lipid XL-10, which enables hepatocyte-specific siRNA transfer, and injected intravenously into hAd5-infected immunosuppressed Syrian hamsters. This resulted in a significant reduction of liver hAd5 titers, a trend toward reduced liver injury and inflammation, and reduction of viral titers in the blood and spleen compared with hAd5-infected animals that received a non-silencing siRNA. These effects were demonstrated in animals infected with low and moderate doses of hAd5. These data demonstrate that hepatic hAd5 infection can be successfully treated with anti-adenoviral sipTPmod encapsulated in LNPs.
Investigations towards incorporation of Eu3+ and Cm3+ during ZrO2 crystallization in aqueous solution
Creators: name: Opitz, Lucas
name: Hübner, René
name: Shams Aldin Azzam, Salim
name: Gilson, Sara E.
name: Finkeldei, Sarah C.
name: Huittinen, Nina
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: spent nuclear fuel
subject: safe storage
subject: deep geological repository
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Nuclear energy provides a widely applied carbon-reduced energy source. Following operation, the spent nuclear fuel (SNF), containing a mixture of radiotoxic elements such as transuranics, needs to be safely disposed of. Safe storage of SNF in a deep geological repository (DGR) relies on multiple engineered and natural retention barriers to prevent environmental contamination. In this context, zirconia (ZrO2) formed on the SNF rod cladding, could be employed as an engineered barrier for immobilization of radionuclides via structural incorporation. This study investigates the incorporation of Eu3+ and Cm3+, representatives for trivalent transuranics, into zirconia by co-precipitation and crystallization in aqueous solution at 80 °C. Complementary structural and microstructural characterization has been carried out by powder X-ray diffraction (PXRD), spectrum imaging analysis based on energy-dispersive X-ray spectroscopy in scanning transmission electron microscopy mode (STEM-EDXS), and luminescence spectroscopy. The results reveal the association of the dopants with the zirconia particles and elucidate the presence of distinct bulk and superficially incorporated species. Hydrothermal aging for up to 460 days in alkaline media points to great stability of these incorporated species after initial crystallization, with no indication of phase segregation or release of Eu3+ and Cm3+ over time. These results suggest that zirconia would be a suitable technical retention barrier for mobilized trivalent actinides in a DGR.
Sensitive Tenofovir Resistance Screening of HIV-1 From the Genital and Blood Compartments of Women With Breakthrough Infections in the CAPRISA 004 Tenofovir Gel Trial
Creators: name: Abdool Karim, Salim S.
name: Morris, Lynn
name: Hunt, Gillian
name: Abdool Karim, Quarraisha
name: Sibeko, Sengeziwe
name: Kashuba, Angela D. M.
name: Johnson, Jeffrey A.
name: Li, Jin-fen
name: Heneine, Walid
name: Werner, Lise
name: Wei, Xierong
name: Naranbhai, Vivek
name: Passmore, Jo-Ann S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction–based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion.
Flipping minor bodies: what comet 96P/Machholz 1 can tell us about the orbital evolution of extreme trans-Neptunian objects and the production of near-Earth objects on retrograde orbits
Creators: name: Marcos, C. de la Fuente
name: Marcos, R. de la Fuente
name: Aarseth, S. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Nearly all known extreme trans-Neptunian objects (ETNOs) have argument of perihelion close to 0 degrees. An existing observational bias strongly favours the detection of ETNOs with arguments of perihelion close to 0 degrees and 180 degrees yet no objects have been found at 180 degrees. No plausible explanation has been offered so far to account for this unusual pattern. Here, we study the dynamical evolution of comet 96P/Machholz 1, a bizarre near-Earth object (NEO) that may provide the key to explain the puzzling clustering of orbits around argument of perihelion close to 0 degrees recently found for the population of ETNOs. Comet 96P/Machholz 1 is currently locked in a Kozai resonance with Jupiter such that the value of its argument of perihelion is always close to 0 degrees at its shortest possible perihelion (highest eccentricity and lowest inclination) and about 180 degrees near its shortest aphelion (longest perihelion distance, lowest eccentricity and highest inclination). If this object is a dynamical analogue (albeit limited) of the known ETNOs, this implies that massive perturbers must keep them confined in orbital parameter space. Besides, its future dynamical evolution displays orbital flips when its eccentricity is excited to a high value and its orbit turns over by nearly 180 degrees, rolling over its major axis. This unusual behaviour, that is preserved when post-Newtonian terms are included in the numerical integrations, may also help understand the production of NEOs on retrograde orbits.
description: 8 pages, 8 figures, 2 tables. Revised to reflect final version published in Monthly Notices of the Royal Astronomical Society
Temporal Trends in Syphilis and Gonorrhea Incidences in Guangdong Province, China
Creators: name: Yang, Li-Gang
name: Tucker, Joseph D.
name: Yang, Bin
name: Emch, Michael E.
name: Tan, Nicholas X.
name: Tan, Grace X.
name: Powers, Kimberly A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The high burden of syphilis in China presents a unique opportunity to examine temporal trends. This study used wavelet transformation and Fourier analysis to assess the presence of temporal oscillations in the incidence of syphilis among adults, gonorrhea, and congenital syphilis over 11 years in China's largest province. This study found a significant annual oscillation trend in the incidence of adult syphilis, consistent with a peak during July–September, which was 4-fold higher than the trough, which occurred during January–March. A similar but dampened trend was observed in the incidence of gonorrhea, and no trend was observed for the incidence of congenital syphilis. Further research on the temporal oscillation of the incidence of syphilis is needed.
LONG-TERM DEVELOPMENT STRATEGY IN THE FIELD OF TELECOMMUNICATIONS SERVICES
Creators: name: Ochilov, Laziz
Publisher: name: Zenodo
Year: 2023

description: Virtual markets have been shown to provide new opportunities for merchants as telecommunications services evolve, combining traditional marketing tools with networked Internet communications and digital marketing techniques. It is proposed that the rapid development of information and communication technologies, the digitalization of the economy, the growth of consumer information culture, increase the presence of enterprises in the virtual space and radically change marketing methods.
Plan de Acción para el Acceso Abierto Diamante
Creators: name: Ancion, Zoé
name: Borrell-Damián, Lidia
name: Mounier, Pierre
name: Rooryck, Johan
name: Saenen, Bregt
Publisher: name: Zenodo
Year: 2023
Subjects: Diamond Open Access

description: Science Europe, cOAlition S, OPERAS, and the French National Research Agency (ANR) present an Action Plan for Diamond Open Access to further develop and expand a sustainable, community-driven Diamond OA scholarly communication ecosystem. It focuses on efficiency, quality standards, capacity building, and sustainability, and it addresses the alignment and development of common resources for the whole Diamond OA ecosystem, including journals and platforms, while respecting the cultural, multilingual, and disciplinary diversity that constitutes the strength of the sector. The Action Plan intends to create an inclusive worldwide community that has the tools to strengthen existing Diamond OA journals and platforms and increase their visibility.
Lensing in the Geodesic Light-Cone coordinates and its (exact) illustration to an off-center observer in Lemaître-Tolman-Bondi models
Creators: name: Fanizza, Giuseppe
name: Nugier, Fabien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present in this paper a new application of the geodesic light-cone (GLC) gauge for weak lensing calculations. Using interesting properties of this gauge, we derive an exact expression of the amplification matrix - involving convergence, magnification and shear - and of the deformation matrix - involving the optical scalars. These expressions are simple and non-perturbative as long as no caustics are created on the past light-cone and are, by construction, free from the thin lens approximation. We apply these general expressions on the example of an Lemaître-Tolman-Bondi (LTB) model with an off-center observer and obtain explicit forms for the lensing quantities as a direct consequence of the non-perturbative transformation between GLC and LTB coordinates. We show their evolution in redshift after a numerical integration, for underdense and overdense LTB models, and interpret their respective variations in the simple non-curvature case.
description: 19 pages, 18 figures
FCM-RDpA: TSK Fuzzy Regression Model Construction Using Fuzzy C-Means Clustering, Regularization, DropRule, and Powerball AdaBelief
Creators: name: Shi, Zhenhua
name: Wu, Dongrui
name: Guo, Chenfeng
name: Zhao, Changming
name: Cui, Yuqi
name: Wang, Fei-Yue
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: To effectively optimize Takagi-Sugeno-Kang (TSK) fuzzy systems for regression problems, a mini-batch gradient descent with regularization, DropRule, and AdaBound (MBGD-RDA) algorithm was recently proposed. This paper further proposes FCM-RDpA, which improves MBGD-RDA by replacing the grid partition approach in rule initialization by fuzzy c-means clustering, and AdaBound by Powerball AdaBelief, which integrates recently proposed Powerball gradient and AdaBelief to further expedite and stabilize parameter optimization. Extensive experiments on 22 regression datasets with various sizes and dimensionalities validated the superiority of FCM-RDpA over MBGD-RDA, especially when the feature dimensionality is higher. We also propose an additional approach, FCM-RDpAx, that further improves FCM-RDpA by using augmented features in both the antecedents and consequents of the rules.
Chloropentaphenyldisiloxane—Model Study on Intermolecular Interactions in the Crystal Structure of a Monofunctionalized Disiloxane
Creators: name: Bauer, Jonathan O.
name: Götz, Tobias
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: disiloxanes; intermolecular interactions; Hirshfeld surface analysis; molecular models; silicon; X-ray crystallography
subject: 540 Chemie

description: Small functional siloxane units have gained great interest as molecular model systems for mimicking more complex silicate structures both in nature and in materials chemistry. The crystal structure of chloropentaphenyldisiloxane, which was synthesized for the first time, was elucidated by single-crystal X-ray diffraction analysis. The molecular crystal packing was studied in detail using state-of-the-art Hirshfeld surface analysis together with a two-dimensional fingerprint mapping of the intermolecular interactions. It was found that the phenyl C–H bonds act as donors for both weak C–H···π and C–H···Cl hydrogen bond interactions. The influence of intramolecular Si–O–Si bond parameters on the acceptor capability of functional groups in intermolecular hydrogen bond interactions is discussed.
Universitätsarchiv, Humboldt-Universität, Berlin
Creators: name: Giltaij, Jacob
name: Tuori, Kaius
name: Beggio, Tommaso
Publisher: name: Zenodo
Year: 2018
Subjects: Fritz Schulz
Paul Koschaker
Hermann Grapow
Hans Weigmann

description: Archival notes from Universitätsarchiv, Humboldt-Universität zu Berlin, Berlin. UK Personalia Sch 303 Bd. I-III: The personnel files regarding Fritz Schulz, his hiring and dismissal. UK Personalia K 274 Bd. II, Bl. 6-12 und 14: Six letters: three letters by Paul Koschaker, one by Professor Grapow, one by Professor Weigmann, and one by the Reichsminister für Wissenschaft, Erziehung und Volksbildung.