Additional file 1 of Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis
Creators: name: Zhang, Yuwei
name: Jia, Ru
name: Zhang, Yifei
name: Sun, Xuefei
name: Mei, Yukun
name: Zou, Rui
name: Niu, Lin
name: Dong, Shaojie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1: Table S1. Inclusion and exclusion criteria and studies excluded after full-text analysis and related reasons. Table S2. The detailed effect of NSPT in respect to inflammatory cytokines and adipokines. Table S3. Synthesis of results in subgroup analyses. Table S4. Risk of bias assessment of included studies according to the ROBINS-I tool. Table S5. Risk of bias assessment of the 4 included RCTs with the ROB-2 tool. Figure S1. Subgroup analysis comparing baseline serum levels of IL-6 before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S2. Subgroup analysis comparing serum levels of IL-6 before and three months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) group. Figure S3. Comparison of 3-month follow-up of serum levels of IL-6 after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S4. Subgroup analysis comparing baseline GCF levels of IL-6 before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S5. Subgroup analysis comparing GCF levels of IL-6 before and three months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S6. Comparison of 3-month follow-ups of GCF levels of IL-6 after non-surgical periodontal therapy for patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S7. Subgroup analysis comparing GCF levels of IL-6 before and distal follow-up time after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S8. Subgroup analysis comparing GCF levels of IL-6 before and distal follow-up time after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S9. Subgroup analysis comparing baseline serum levels of TNF-a before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S10. Subgroup analysis comparing serum levels of TNF-a before and three months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S11. Subgroup analysis comparing serum levels of TNF-a before and three months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S12. Subgroup analysis comparing baseline GCF levels of TNF-a before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S13. Subgroup analysis comparing GCF levels of TNF-a before and three months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S14. Comparison of three-month follow-ups of GCF levels of TNF-a after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S15. Subgroup analysis comparing GCF levels of TNF-a before and distal follow-up time after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S16. Subgroup analysis comparing GCF levels of TNF-a before and distal follow-up time after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S17. Subgroup analysis comparing distal follow-up time GCF levels of TNF-a after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S18. Subgroup analysis comparing baseline serum levels of CRP/hs-CRP before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S19. Subgroup analysis comparing serum levels of CRP/hs-CRP before and 3 months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S20. Subgroup analysis comparing serum levels of CRP/hs-CRP before and 3 months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S21. Subgroup analysis comparing follow-up serum levels of CRP/hs-CRP 3 months after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S22. Subgroup analysis comparing salivary levels of resistin before and distal time after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S23. Subgroup analysis comparing baseline GCF levels of resistin before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S24. Subgroup analysis comparing GCF levels of resistin before and distal time after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S25. Subgroup analysis comparing GCF levels of resistin before and distal time after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S26. The comparing distal follow-up time GCF levels of resistin after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S27. Subgroup analysis comparing baseline serum levels of resistin before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S28. Subgroup analysis comparing serum levels of resistin before and distal time after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S29. Subgroup analysis comparing serum levels of resistin before and distal time after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S30. Comparison of distal follow-up time serum levels of resistin after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S31. Subgroup analysis comparing baseline serum levels of adiponectin before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S32. Subgroup analysis comparing serum levels of adiponectin before and three months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S33. Subgroup analysis comparing serum levels of adiponectin before and three months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S34. Subgroup analysis comparing 3 months follow-up serum levels of adiponectin after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S35. Subgroup analysis comparing serum levels of adiponectin before and six months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S36. Subgroup analysis comparing serum levels of adiponectin before and six months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S37. Subgroup analysis comparing 6 months follow-up serum levels of adiponectin after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S38. Subgroup analysis comparing baseline GCF levels of adiponectin before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S39. Subgroup analysis comparing GCF levels of adiponectin before and three months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S40. Subgroup analysis comparing 3 months follow-up GCF levels of adiponectin after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S41. Subgroup analysis comparing baseline serum levels of leptin before non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S42. Subgroup analysis comparing serum levels of leptin before and three months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S43. Subgroup analysis comparing serum levels of leptin before and three months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups. Figure S44. Subgroup analysis comparing 3 months follow-up serum levels of leptin after non-surgical periodontal therapy within patients with obesity and periodontitis (OP) and normal-weight patients with periodontitis (NP) groups. Figure S45. Subgroup analysis comparing serum levels of leptin before and six months after non-surgical periodontal therapy in patients with obesity and periodontitis (OP) groups. Figure S46. Subgroup analysis comparing serum levels of leptin before and six months after non-surgical periodontal therapy in normal-weight patients with periodontitis (NP) groups.