cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease
Creators: name: Roman, T.S.
name: Mohlke, K.L.
Publisher: name: Elsevier Ltd
Year: 2018

description: Many genome-wide association studies (GWAS) have identified signals located in non-coding regions, and an increasing number of functional genomics annotations of regulatory elements and assays of regulatory activity have been used to investigate mechanisms. Genome-wide datasets that characterize chromatin structure help detect potential regulatory elements. Assays to experimentally assess candidate variants include transcriptional reporter assays, and recently, massively parallel reporter assays (MPRAs). Additionally, the effect of candidate regulatory elements and variants on gene expression and function can be evaluated using genomic editing with the CRISPR-Cas9 technology. We highlight some recent studies that employed these strategies to identify variant effects and elucidate molecular and/or biological mechanisms at GWAS loci for lipid traits and coronary artery disease.
ИССЛЕДОВАНИЕ ВЛИЯНИЯ ФИЗИЧЕСКОЙ НАГРУЗКИ НА КОГНИТИВНУЮ ДЕЯТЕЛЬНОСТЬ СТУДЕНТОВ
Creators: name: К. С. Нестеренко
name: Д. Б. Скворцова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: физическая нагрузка; когнитивная деятельность; спорт
высшая нервная деятельность
головной мозг
кровоснабжение
функциональная гиперемия

description: В данной работе представлены результаты исследования взаимосвязи физических нагрузок и когнитивной деятельности студентов. Установлено, что большинство студентов, регулярно занимающихся физическими нагрузками, после пробы Мартине (15 приседаний за 30 секунд) решили предложенные математические задачи быстрее и правильнее, чем до пробы, т.е. у них наблюдается положительное воздействие физической нагрузки на когнитивную деятельность. У группы студентов, не занимающихся спортом, наблюдается примерно одинаковое соотношение тех, кто решил быстрее математические уравнения до пробы, и тех, кто решил их быстрее после пробы.
ИССЛЕДОВАНИЕ ВЛИЯНИЯ КАЧЕСТВА СНА НА КОГНИТИВНУЮ ДЕЯТЕЛЬНОСТЬ СТУДЕНТОВ
Creators: name: К. С. Нестеренко
name: Д. В. Шпингис
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: когнитивная деятельность
сон
парадоксальный сон
обучение
память
качество сна.

description: В данной работе представлены результаты исследования взаимосвязи между качеством сна и когнитивной деятельностью студентов. Установлено, что большинство студентов, у которых было высокое качество сна, получали положительные оценки. Также, те студенты, которые готовились к занятиям вечером или перед сном, имели средний рейтинг выше, чем те, кто готовился перед занятиями.
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
Creators: name: Boehnke, M.
name: Ko, A.
name: Pajukanta, P.
name: Raulerson, C.K.
name: Miao, Z.
name: Boocock, J.
name: Garske, K.M.
name: Alvarez, M.
name: Mohlke, K.L.
name: Civelek, M.
name: Lusis, A.J.
name: Sinsheimer, J.S.
name: Bhagat, Y.V.
name: Small, K.S.
name: Glastonbury, C.A.
name: Laakso, M.
name: Cantor, R.M.
name: Pan, D.Z.
name: Nikkola, E.
Publisher: name: Nature Publishing Group
Year: 2018

description: Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We find that promoter-interacting elements in human adipocytes are enriched for adipose-related transcription factor motifs, such as PPARG and CEBPB, and contribute to heritability of cis-regulated gene expression. We further intersect these data with published genome-wide association studies for BMI and BMI-related metabolic traits to identify the genes that are under genetic cis regulation in human adipocytes via chromosomal interactions. This integrative genomics approach identifies four cis-eQTL-eGene relationships associated with BMI or obesity-related traits, including rs4776984 and MAP2K5, which we further confirm by EMSA, and highlights 38 additional candidate genes.
ВЛИЯНИЕ РАСТИТЕЛЬНОГО ПОКРОВА НА СТОК РЕКИ АКТАЙ
Creators: name: Ю. В. Мутыгуллина
name: О. Н. Урбанова
name: А. Т. Горшкова
name: Н. В. Бортникова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: стокоформирующие комплексы
рассчитанные и наблюденные гидрографы стока.

description: С помощью компьютерной программы «Гидрограф» определено влияние растительности на сток реки Актай, протекающей по территории Республики Татарстан. С целью определения этого влияния для двух однородных по типу формирования стока участков водосбора, но с различным растительным покровом (лес и степь) были построены и сопоставлены наблюденные (фактические) и рассчитанные (смоделированные) гидрографы стока. Сопоставление этих гидрографов показывало, что время наступления основных фаз гидрологического режима, и в частности, весеннего половодья, на реке Актай и на степных и на лесных территориях практически совпадает. Но отмечено четкое отличие в величине пиков (максимальных расходов) половодья. На степных территориях максимум половодья выше, чем на лесных водосборах.
The HArps-n red Dwarf Exoplanet Survey (HADES). Flux-flux and activity-rotation rela- tionships in early-M dwarfs
Creators: name: Maldonado, J.
Publisher: name: Zenodo
Year: 2023

description: While most of the planets discovered so far have been found orbiting around solar-type stars, low-mass stars have recently been recognised as a "shortcut" to glance into an exo-life laboratory. Currently, stellar activity is one of the most limiting factors for achieving the precision required to detect Earth-twins via the radial velocity method. Understanding the chromospheres of M dwarfs is crucial to solve this problem. In this contribution we present a study of the activity-rotation-stellar parameters and flux-flux relationships among a large sample of early-M dwarfs which are currently being monitored in the framework of the HADES (HArps-n red Dwarf Exoplanet Survey) radial velocity survey.
Generalized Prolate Spheroidal Wave Functions: Spectral Analysis and Approximation of Almost Band-limited Functions
Creators: name: Karoui, Abderrazek
name: Souabni, Ahmed
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: Primary 42C10, 33E10, Secondary 34L10, 41A30

description: In this work, we first give various explicit and local estimates of the eigenfunctions of a perturbed Jacobi differential operator. These eigenfunctions generalize the famous classical prolate spheroidal wave functions (PSWFs), founded in 1960's by D. Slepian and his co-authors and corresponding to the case $α=β=0.$ They also generalize the new PSWFs introduced and studied recently in \cite{Wang2}, denoted by GPSWFs and corresponding to the case $α=β> -1.$ The main content of this work is devoted to the previous interesting special case $α=β.$ In particular, we give further computational improvements, as well as some useful explicit and local estimates of the GPSWFs. More importantly, by using the concept of a restricted Paley-Wiener space, we relate the GPSWFs to the solutions of a generalized energy maximisation problem. As a consequence, many desirable spectral properties of the self-adjoint compact integral operator associated with the GPSWFs are deduced from the rich literature of the PSWFs. In particular, we show that the GPSWFs are well adapted for the spectral approximation of the classical $c-$band-limited as well as almost $c-$band-limited functions. Finally, we provide the reader with some numerical examples that illustrate the different results of this work.
СОВРЕМЕННЫЕ АКУШЕРСКИЕ АСПЕКТЫ ПРОГНОЗИРОВАНИЯ И ТАКТИКИ ВЕДЕНИЯ ПЕРЕНОШЕННОЙ БЕРЕМЕННОСТИ
Creators: name: Исмаилова, Мавлюда
Publisher: name: Zenodo
Year: 2024

description: Переношенная беременность на сегодняшний день является одной из актуальных проблем в акушерстве, в связи с высокой частотой патологических процессов как со стороны родового акта, так и со стороны плода, что приводит к повышению перинатальной смертности. Частота перенашивания составляет 1,4-14%, в среднем 8% [1,2]. Перинатальная смертность при переношенной беременности достигает 19%, а неонатальная заболеваемость-29%. Это связанно с низкой устойчивостью плода к гипоксии вследствие повышенной зрелости структур головного мозга плода и уменьшения поступления к нему кислорода из-за морфо­функциональных инволютивных изменений в плаценте.
Anderson localization and the topology of classifying spaces
Creators: name: Morimoto, Takahiro
name: Furusaki, Akira
name: Mudry, Christopher
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We construct the generic phase diagrams encoding the topologically distinct localized and delocalized phases of noninteracting fermionic quasiparticles for any symmetry class from the tenfold way in one, two, and three dimensions. To this end, we start from a massive Dirac Hamiltonian perturbed by a generic disorder for any dimension of space and for any one of the ten symmetry classes from the tenfold way. The physics of Anderson localization is then encoded by a two-dimensional phase diagram that we deduce from the topology of the space of normalized Dirac masses. This approach agrees with previously known results and gives an alternative explanation for the even-odd effect in the one-dimensional chiral symmetry classes. We also give a qualitative explanation for the Gade singularity and Griffiths effects in the density of states using the first homotopy group of the normalized Dirac masses in two dimensions. Finally, this approach is used to analyze the stability of massless Dirac fermions on the surface of three-dimensional topological crystalline insulators.
description: 45 pages, 6 figures
ИНКЛЮЗИВНОЕ ОБРАЗОВАНИЕ В КЫРГЫЗСТАНЕ
Creators: name: А. К. Аккожоева
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: политика
инклюзив
наука
образования
разные.

description: В статье рассматриваются вопросы инклюзивного образования, определяются понятия «инклюзия» и «инклюзивное образование». Особое внимание было уделено анализу подходов к функционированию инклюзивного образования и концепций реализации инклюзивного образования в Кыргызской Республике. Обучение детей с ограниченными возможностями здоровья через инклюзивное образование предполагает понимание включения новой философии образования, которая создает современный гуманистический подход к образованию, в основе которого лежит многообразие учащихся и больше индивидуальных особенностей ребенка, нежели проблем, а также возможность совместно обогащать воспитание обычных детей и детей с ограниченными возможностями здоровья.
Quanto custa formar um médico? Análise Estruturada dos Projetos Político-Pedagógicos dos Cursos de Medicina no Brasil
Creators: name: Valentin, Ericka K.
name: Silva Jr., Dercio S.
name: Maia, Leila S.
name: Ramalho, Laylla S.
name: Amaral, Jorge L.
name: Dal Poz, Mario R.
Publisher: name: Zenodo
Year: 2022

description: O número de cursos e a quantidade total de vagas nos cursos de medicina têm aumentado no Brasil desde a década de 1990. Apesar de sua importância e do número crescente, não há um modo sistemático de compará-los. Nem no que tange a custos, nem no que tange à qualidade. O documento que deveria servir para este fim, o Projeto Político-Pedagógico (PPP), apesar de obrigatório, não tem forma definida, e há muita discricionariedade no modo como ele é elaborado. E ainda, apesar de ser, além de obrigatório, um documento público, ele nem sempre está disponível nos websites dos cursos. Este relatório registra o esforço de levantamento da existência desse documento nos websites do curso e analisa o rol de informações neles existente, buscando entender o quanto estas são comparáveis entre si. The number of courses and the total number of vacancies in medicine courses have increased in Brazil since the 1990s. Despite their importance and the growing number, there is no systematic way to compare them. Neither in terms of costs nor in terms of quality. The document that should serve for this purpose, the Pedagogical Political Project (PPP), although mandatory, does not have a defined form, and there is a lot of discretion in the way it is prepared. And yet, despite being, in addition to being mandatory, a public document, it is not always available on the courses’ websites. This report records the effort to survey the existence of a document on the courses’ websites and analyzes the list of information on them, seeking to understand how much they are comparable with each other.
VIINTER: View Interpolation with Implicit Neural Representations of Images
Creators: name: Feng, Brandon Yushan
name: Jabbireddy, Susmija
name: Varshney, Amitabh
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Graphics (cs.GR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: We present VIINTER, a method for view interpolation by interpolating the implicit neural representation (INR) of the captured images. We leverage the learned code vector associated with each image and interpolate between these codes to achieve viewpoint transitions. We propose several techniques that significantly enhance the interpolation quality. VIINTER signifies a new way to achieve view interpolation without constructing 3D structure, estimating camera poses, or computing pixel correspondence. We validate the effectiveness of VIINTER on several multi-view scenes with different types of camera layout and scene composition. As the development of INR of images (as opposed to surface or volume) has centered around tasks like image fitting and super-resolution, with VIINTER, we show its capability for view interpolation and offer a promising outlook on using INR for image manipulation tasks.
description: SIGGRAPH Asia 2022
A type 2 diabetes-associated functional regulatory variant in a pancreatic islet enhancer at the ADCY5 locus
Creators: name: Varshney, A.
name: Vadlamudi, S.
name: Roman, T.S.
name: Erdos, M.R.
name: Stitzel, M.L.
name: Morken, M.A.
name: Parker, S.C.J.
name: Collins, F.S.
name: Jackson, A.U.
name: Kuusisto, J.
name: Welch, R.P.
name: Buchkovich, M.L.
name: Boehnke, M.
name: Kursawe, R.
name: Laakso, M.
name: Mohlke, K.L.
name: Wu, Y.
name: Wolford, B.N.
name: Kwon, G.J.
name: Cannon, M.E.
name: Scott, L.J.
Publisher: name: American Diabetes Association Inc.
Year: 2017

description: Molecular mechanisms remain unknown for most type 2 diabetes genome-wide association study identified loci. Variants associated with type 2 diabetes and fasting glucose levels reside in introns of ADCY5, a gene that encodes adenylate cyclase 5. Adenylate cyclase 5 catalyzes the production of cyclic AMP, which is a second messenger molecule involved in cell signaling and pancreatic β-Cell insulin secretion. We demonstrated that type 2 diabetes risk alleles are associated with decreased ADCY5 expression in human islets and examined candidate variants for regulatory function. rs11708067 overlaps a predicted enhancer region in pancreatic islets. The type 2 diabetes risk rs11708067-A allele showed fewer H3K27ac ChIP-seq reads in human islets, lower transcriptional activity in reporter assays in rodent b-cells (rat 832/13 and mouse MIN6), and increased nuclear protein binding compared with the rs11708067-G allele. Homozygous deletion of the orthologous enhancer region in 832/13 cells resulted in a 64% reduction in expression level of Adcy5, but not adjacent gene Sec22a, and a 39% reduction in insulin secretion. Together, these data suggest that rs11708067-A risk allele contributes to type 2 diabetes by disrupting an islet enhancer, which results in reduced ADCY5 expression and impaired insulin secretion.
title: Why engaging on children's rights internationally matters at the local level : 2021 days of general discussion on children's rights and alternative care
Creators: name: Giraldi, Miriana
Publisher: name: Strathprints - University of Strathclyde
Year: 2021

description: With the forthcoming Days of General Discussion (DGD) on the Rights of the Child scheduled to take place in September 2021 to consider children's rights and alternative care, this article reflects on the opportunities provided by this initiative to engage with the UN Committee on the Rights of the Child as a global community. Looking at the role of the Committee and considering all the progress and achievement that has been possible since the 2005 Day of General Discussion, the article explains the purpose and ambition of the 2021 DGD, and makes the case for active participation and involvement in international policy and legal work in order to support the work at the local level, and in countries and communities around the world.
CONCEPTS OF PEDAGOGICAL PROCESS AND ITS PSYCHOLOGICAL BASES
Creators: name: A. Alipbek
name: Zh. Balazhanova
name: L. Abisheva
name: A. Kopabayeva
name: G. Kulanbayeva
name: A. Sultanbekova
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: concept
pedagogy
process
psychology
basis
purpose
education
role
integrity
personality.

description: This article examines some conceptual differences between different approaches of the stage of determination, the purpose of education and the side of the property, the personality traits. And here the authors highlight as the most significant in sociocultural, activity and personal aspects of the pedagogical process. The authors will briefly define the role of a holistic person in education, which is important to the teacher and psychologist not only in the psychopedagogical plan itself, but also in their worldview and methodological priorities of understanding such a complex phenomenon as the personality appears.
АНАЛИЗ РАЗЛИЧНЫХ УРОВНЕЙ И МЕТОДОВ АКТИВИЗАЦИИ ПОЗНАВАТЕЛЬНОЙ ДЕЯТЕЛЬНОСТИ УЧАЩИХСЯ НА УРОКАХ ФИЗИКИ
Creators: name: Д. Б. Бабаев
name: Н. Э. Кылычова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: методы
процессы
технический
уроки.

description: В данной статье анализируется различных средств и методов активизации познавательной деятельности учащихся на уроках физики, а также их практическое применение. В настоящее время учебный процесс требует постоянного совершенствования, так как происходит смена приоритетов и социальных ценностей: научнотехнический прогресс все больше осознается как средство достижения такого уровня производства, который в наибольшей мере отвечает удовлетворению постоянно повышающихся потребностей человека, развитию духовного богатства личности. Причины недостаточной эффективности современного учебного процесса в развитии познавательной активности студентов прямо или опосредованно обусловлены недостатками в организации учебного процесса. Необходима целенаправленная, систематическая работа по формированию активной познавательной деятельности студентов.
Supplementary Information from Hybrid sideways/longitudinal swimming in the monoflagellate Shewanella oneidensis: from aerotactic band to biofilm
Creators: name: Stricker, Laura
name: Guido, Isabella
name: Breithaupt, Thomas
name: Mazza, Marco G.
name: Vollmer, Jürgen
Publisher: name: The Royal Society
Year: 2020
Subjects: Biophysics

description: Shewanella oneidensis MR-1 are facultative aerobic electroactive bacteria with an appealing potential for sustainable energy production and bioremediation. They gather around air sources, forming aerotactic bands and biofilms. Here, we experimentally follow the evolution of the band around an air bubble, and we find good agreement with the numerical solutions of the pertinent transport equations. Video microscopy reveals a transition between motile and non-motile MR-1 upon oxygen depletion, preventing further development of the biofilm. We discover that MR-1 can alternate between longitudinal fast and sideways slow swimming. The resulting bimodal velocity distributions change in response to different oxygen concentrations and gradients, supporting the biological functions of aerotaxis and confinement.
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease
Creators: name: He, M.
name: Guo, X
name: Wu, Y.
name: Dorajoo, R.
name: Wu, T.
name: Wang, L.
name: Gordon-Larsen, P.
name: Wang, F.
name: Fritsche, L.G.
name: Shi, J.
name: Yang, X.
name: Li, J.
name: Chen, Y.-D.I.
name: Huang, W.,
name: Lu, X.
name: Wang, Y.
name: Ganesh, S.K.
name: Huo, Y.
name: Zhang, Y.
name: Sun, L.s
name: Hu, Y.
name: Huang, J.
name: Li, H.
name: Sham, P.C.
name: Liu, J.
name: Peloso, G.M.
name: Wong, T.Y.
name: Feranil, A.B.
name: Willer, C.J.
name: Zhou, W.
name: Zhao, W.
name: Gao, Y.-T.
name: Cheung, C.Y.Y.
name: Chen, S.
name: Du, S.
name: Lam, K.S.L.
name: Chen, Y.
name: Sheu, W.H.-H.
name: Zheng, W.
name: Khor, C.C.
name: Fan, Q.
name: Cai, Q.
name: Spracklen, C.N.
name: Yu, K.
name: Zhang, H.
name: Cherny, S.S.
name: Liu, D.J.
name: Cheng, C.-Y.
name: Shu, X.-O.
name: Gu, D.
name: Xu, M.
name: Mo, Z.
name: Gao, W.
name: Long, J.
name: Chen, Y.E.
name: Abecasis, G.
name: Tse, H.-F.
name: Nielsen, J.B.
name: Adair, L.S.
name: Lin, X.
name: Hveem, K.
name: Varma, R.
name: Liu, X.
name: Tang, C.S.-M.
name: Mohlke, K.L.
name: Kathiresan, S.
name: Tai, E.S.
Publisher: name: Nature Publishing Group
Year: 2017

description: Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations. After a meta-analysis including >300,000 European samples, we identified an additional nine novel loci. Sixteen genes were identified by protein-altering variants in both East Asians and Europeans, and thus are likely to be functional genes. Our data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci.
РАЗВИТИЕ МЫШЛЕНИЯ И КОММУНИКАЦИЙ СПЕЦИАЛИСТОВ НА ОСНОВЕ ИНТЕНСИВНЫХ ОБРАЗОВАТЕЛЬНЫХ ТЕХНОЛОГИЙ
Creators: name: Б. Н. Герасимов
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: экономика
культура
мышление
деятельность
коммуникации
средства
результаты.

description: Различные области деятельности, которые несмотря на противоречия и различные приоритеты, вынуждены находить общий язык и приходить к консенсусу. В настоящее время много внимания уделяется взаимодействию процессов мышления и коммуникаций в индивидуальных и групповых отношениях людей. Для этого существуют определенные методологические и образовательные инструменты. Благодаря применению этих инструментов, содержащих определенные средства возможно получение желаемого спектра ожидаемых результатов при решении междисциплинарных проблем, в частности, связанных с экономикой, культурой и безопасностью жизнедеятельности.
$Λ(1405)$ observations in p+p and K$^-$-induced reactions
Creators: name: Fabbietti, L.
name: Pischicchia, K.
name: Scordo, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The $Λ(1405)$ production in p+p collisions at 3.5 GeV and K$^-$-induced reactions is discussed. The shift of the measured spectral function of the $Λ(1405)$ in p+p reactions does not match either theoretical calculations for p+p reactions or experimental observation in previous K$^-$-induced reactions. New experiments with stopped and in-flight $K^-$ are needed to study this initial state more in detail. The state of the art of the analysis is discussed.
description: 8 pages, 5 pictures, Proceedings of the Exa2014 conference
ИНКЛЮЗИВНОЕ ФИЗИЧЕСКОЕ ВОСПИТАНИЕ СТУДЕНТОВ-ИНВАЛИДОВ: ПРОБЛЕМЫ И ПУТИ ИХ РЕШЕНИЯ
Creators: name: Е. Г. Ермакова
name: Д. Н. Прянишникова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: инвалидность
адаптивная физическая культура (АФК)
студентыинвалиды
ограничение возможностей здоровья (ОВЗ)
опорно-двигательный аппарат (ОДА).

description: Статья посвящена актуальной на сегодняшний день проблеме инклюзивного физического воспитания студентов-инвалидов. Описано влияние инклюзивного воспитания на физическую подготовку и состояние в студента в целом, показаны специалисты адаптивной физической культуры, их критерии для составления комплекса упражнений, предложены примерные упражнения адаптивной физической культуры для студентов-инвалидов с нарушением опорно-двигательного аппарата, применяемые на занятиях физической культуры и рекомендации к нему.
Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study
Creators: name: Lange, E.M.
name: Richardson, A.S.
name: Lange, L.A.
name: North, K.E.
name: Harris, K.M.
name: Young, K.L.
name: Graff, M.
name: Mohlke, K.L.
name: Gordon-Larsen, P.
Publisher: name: Blackwell Publishing Ltd
Year: 2016

description: Glycated hemoglobin (HbA1c) is used to classify glycaemia and type 2 diabetes (T2D). Body mass index (BMI) is a predictor of HbA1c levels and T2D. We tested 43 established BMI and obesity loci for association with HbA1c in a nationally representative multiethnic sample of young adults from the National Longitudinal Study of Adolescent to Adult Health [Add Health: age 24–34 years; n = 5641 European Americans (EA); 1740 African Americans (AA); 1444 Hispanic Americans (HA)] without T2D, using two levels of covariate adjustment (Model 1: age, sex, smoking, and geographic region; Model 2: Model 1 covariates plus BMI). Bonferroni adjustment was made for 43 SNPs and we considered P < 0.0011 statistically significant. Means (SD) for HbA1c were 5.4% (0.3) in EA, 5.7% (0.4) in AA, and 5.5% (0.3) in HA. We observed significant evidence for association with HbA1c for two variants near SH2B1 in EA (rs4788102, P = 2.2 × 10−4; rs7359397, P = 9.8 × 10−4) for Model 1. Both results were attenuated after adjustment for BMI (rs4788102, P = 1.7 × 10−3; rs7359397, P = 4.6 × 10−3). No variant reached Bonferroni-corrected significance in AA or HA. These results suggest that SH2B1 polymorphisms are associated with HbA1c, largely independent of BMI, in EA young adults.
ФОРМЫ, ВИДЫ, ЗАДАЧИ РАЗМИНКИ НА ЗАНЯТИЯХ ФИЗИЧЕСКОЙ КУЛЬТУРОЙ. РОЛЬ РАЗМИНКИ ПРИ СДАЧЕ ЗАЧЕТНЫХ НОРМАТИВОВ
Creators: name: Е. Г. Ермакова
name: Д. Н. Прянишникова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: физическая культура
разминка
упражнение
организм
мышцы
зачётные нормативы.

description: В данной статье рассматриваются основные цели, задачи и разделы разминки на занятиях физической культуры и ее влияние на организм, значение и специфика разминки перед сдачей зачётных нормативов у студентов в вузе. Автором проанализированы и подвержены сравнению результаты, полученные в ходе исследования влияния разминки на сдачу зачётных нормативов. Даны некоторые рекомендации и предложения по способам проведения разминки, чтобы активизировать двигательную деятельность.
ЭТАПЫ РАБОТЫ С ЛЕКСИЧЕСКИМ МАТЕРИАЛОМ НА УРОКАХ РКИ В ВОЕННО-МОРСКОМ ВУЗЕ
Creators: name: И. Э. Лосева
name:  Ш. Есенова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: русский язык как иностранный
военно-морской вуз
лексикограмматические навыки
специальная лексика
коммуникативная компетенция.

description: В статье представлена характеристика основных этапов работы с лексикой, в частности ее предъявление, семантизация, контроль понимания и формирование гибкости навыков. Данные этапы работы описаны на базе основных типов упражнений, созданных на материале лексики профессиональной направленности. В качестве основы для упражнений отобрана военно-морская лексика. Таким образом, статья представляет интерес для преподавателей РКИ, работающих в военно-морских учебных заведениях.
Robust network inference using response logic
Creators: name: Gross, Torsten
name: Wongchenko, Matthew
name: Yan, Yibing
name: Blüthgen, Nils
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: 570 Biologie

description: Motivation A major challenge in molecular and cellular biology is to map out the regulatory networks of cells. As regulatory interactions can typically not be directly observed experimentally, various computational methods have been proposed to disentangling direct and indirect effects. Most of these rely on assumptions that are rarely met or cannot be adapted to a given context. Results We present a network inference method that is based on a simple response logic with minimal presumptions. It requires that we can experimentally observe whether or not some of the system’s components respond to perturbations of some other components, and then identifies the directed networks that most accurately account for the observed propagation of the signal. To cope with the intractable number of possible networks, we developed a logic programming approach that can infer networks of hundreds of nodes, while being robust to noisy, heterogeneous or missing data. This allows to directly integrate prior network knowledge and additional constraints such as sparsity. We systematically benchmark our method on KEGG pathways, and show that it outperforms existing approaches in DREAM3 and DREAM4 challenges. Applied to a novel perturbation dataset on PI3K and MAPK pathways in isogenic models of a colon cancer cell line, it generates plausible network hypotheses that explain distinct sensitivities toward various targeted inhibitors due to different PI3K mutants. Availability and implementation A Python/Answer Set Programming implementation can be accessed at github.com/GrossTor/response-logic. Data and analysis scripts are available at github.com/GrossTor/response-logic-projects. Supplementary information Supplementary data are available at Bioinformatics online.
Effects of multi-scale heterogeneity on the simulated evolution of ice-rich permafrost lowlands under a warming climate
Creators: name: Nitzbon, Jan
name: Langer, Moritz
name: Martin, Léo C. P.
name: Westermann, Sebastian
name: Schneider Von Deimling, Thomas
name: Boike, Julia
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: 550 Geowissenschaften

description: In continuous permafrost lowlands, thawing of ice-rich deposits and melting of massive ground ice lead to abrupt landscape changes called thermokarst, which have widespread consequences on the thermal, hydrological, and biogeochemical state of the subsurface. However, macro-scale land surface models (LSMs) do not resolve such localized subgrid-scale processes and could hence miss key feedback mechanisms and complexities which affect permafrost degradation and the potential liberation of soil organic carbon in high latitudes. Here, we extend the CryoGrid 3 permafrost model with a multi-scale tiling scheme which represents the spatial heterogeneities of surface and subsurface conditions in ice-rich permafrost lowlands. We conducted numerical simulations using stylized model setups to assess how different representations of micro- and meso-scale heterogeneities affect landscape evolution pathways and the amount of permafrost degradation in response to climate warming. At the micro-scale, the terrain was assumed to be either homogeneous or composed of ice-wedge polygons, and at the meso-scale it was assumed to be either homogeneous or resembling a low-gradient slope. We found that by using different model setups and parameter sets, a multitude of landscape evolution pathways could be simulated which correspond well to observed thermokarst landscape dynamics across the Arctic. These pathways include the formation, growth, and gradual drainage of thaw lakes; the transition from low-centred to high-centred ice-wedge polygons; and the formation of landscape-wide drainage systems due to melting of ice wedges. Moreover, we identified several feedback mechanisms due to lateral transport processes which either stabilize or destabilize the thermokarst terrain. The amount of permafrost degradation in response to climate warming was found to depend primarily on the prevailing hydrological conditions, which in turn are crucially affected by whether or not micro- and/or meso-scale heterogeneities were considered in the model setup. Our results suggest that the multi-scale tiling scheme allows for simulating ice-rich permafrost landscape dynamics in a more realistic way than simplistic one-dimensional models and thus facilitates more robust assessments of permafrost degradation pathways in response to climate warming. Our modelling work improves the understanding of how micro- and meso-scale processes affect the evolution of ice-rich permafrost landscapes, and it informs macro-scale modellers focusing on high-latitude land surface processes about the necessities and possibilities for the inclusion of subgrid-scale processes such as thermokarst within their models.
Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort
Creators: name: North, K.E.
name: Gordon-Larsen, P.
name: Lange, E.M.
name: Harris, K.M.
name: Richardson, A.S.
name: Mohlke, K.L.
name: Graff, M.
name: Lange, L.A.
name: Young, K.M.
Publisher: name: John Wiley and Sons Ltd
Year: 2014

description: Summary What is already known about this subject Genome-Wide Association Studies have successfully identified numerous genetic loci that influence body mass index in European-descent middle-aged adults. Adolescence is a high-risk period for the development of adult obesity and severe obesity. Physical activity is one of the most promising behavioural candidates for preventing and reducing weight gain, particularly among youth. What this study adds An examination of the joint association between 41 of the well-established obesity susceptibility single-nucleotide polymorphisms with <5 vs. ≥5 bouts of moderate to vigorous physical activity (MVPA) per week in relation to body mass index (BMI)-for-age Z-score in a nationally representative sample of European American, African-American and Hispanic American adolescents. Three nominally significant interactions (P < 0.05) varied by race/ethnicity. Overall, the estimated effect of the risk allele on BMI-for-age Z-score was greater in individuals with <5 than those with ≥5 bouts MVPA per week. Background Little is known about the interaction between genetic and behavioural factors during lifecycle risk periods for obesity and how associations vary across race/ethnicity. Objective The objective of this study was to examine joint associations of adiposity-related single-nucleotide polymorphisms (SNPs) and moderate to vigorous physical activity (MVPA) with body mass index (BMI) in a diverse adolescent cohort. Methods Using data from the National Longitudinal Study of Adolescent Health (n = 8113: Wave II 1996; ages 12-21, Wave III; ages 18-27), we assessed interactions of 41 well-established SNPs and MVPA with BMI-for-age Z-scores in European Americans (EA; n = 5077), African-Americans (AA; n = 1736) and Hispanic Americans (HA; n = 1300). Results Of 97 assessed, we found nominally significant SNP-MVPA interactions on BMI-for-age Z-score in EA at GNPDA2 and FTO and in HA at LZTR2/SEC16B. In EA, the estimated effect of the FTO risk allele on BMI-for-age Z-score was lower (β = -0.13; 95% confidence interval [CI]: 0.08, 0.18) in individuals with ≥5 vs. <5 (β = 0.24; CI: 0.16, 0.32) bouts of MVPA per week (P for interaction 0.02). Race/ethnicity-pooled meta-analysis showed nominally significant interactions for SNPs at TFAP2B, POC5 and LYPLAL1. Conclusions High MVPA may attenuate underlying genetic risk for obesity during adolescence, a high-risk period for adult obesity.
ИСПОЛЬЗОВАНИЕ ИННОВАЦИОННЫХ ФОРМ И МЕТОДИК В ПРОЦЕССЕ ОБУЧЕНИЯ МАТЕМАТИКЕ
Creators: name: В. С. Ляшенко
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: математика
инновации
игровое обучение
методики преподавания

description: Статья посвящена современным педагогическим технологиям, формам и методикам обучения математике. В работе использованы методы графического, сравнительного, аналитического исследования. Автор аргументирует необходимость перехода от архаичных методик обучения математике, характеризующихся простым транслированием знаний и правильных решений, к инновационным, направленным на формирование математического мировоззрения, умственного, творческого, эмоционального развития, навыков самостоятельного поиска решений.
Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort
Creators: name: Young, K.M.
name: Graff, M.
name: Gordon-Larsen, P.
name: Harris, K.M.
name: Mohlke, K.L.
name: Lange, L.A.
name: Lange, E.M.
name: Richardson, A.S.
name: North, K.E.
Publisher: name: John Wiley and Sons Ltd
Year: 2013

description: Background There has been little investigation of gene-by-environment interactions related to sedentary behaviour, a risk factor for obesity defined as leisure screen time (ST; i.e. television, video and computer games). Objective To test the hypothesis that limiting ST use attenuates the genetic predisposition to increased body mass index (BMI), independent of physical activity. Design Using 7642 wave II participants of the National Longitudinal Study of Adolescent Health, (Add Health; mean=16.4 years, 52.6% female), we assessed the interaction of ST (hweek-1) and 41 established obesity single nucleotide polymorphisms (SNPs) with age- and sex-specific BMI Z-scores in 4788 European-American (EA), 1612 African-American (AA) and 1242 Hispanic American (HA) adolescents. Results Nominally significant SNP ST interaction were found for FLJ35779 in EA, GNPDA2 in AA and none in HA (EA: beta [SE]=0.016[0.007]), AA: beta [SE]=0.016[0.011]) per 7hweek-1 ST and one risk allele in relation to BMI Z-score. Conclusions While for two established BMI loci, we find evidence that high levels of ST exacerbate the influence of obesity susceptibility variants on body mass; overall, we do not find strong evidence for interactions between the majority of established obesity loci. However, future studies with larger sample sizes, or that may build on our current study and the growing published literature, are clearly warranted.
ЗНАЧЕНИЕ ФОРМИРОВАНИЯ ДИАЛЕКТИЧЕСКОГО МЫШЛЕНИЯ В СОВРЕМЕННОМ ИНФОРМАЦИОННОМ ОБЩЕСТВЕ
Creators: name: А. А. Поляруш
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: компетенции
система знаний
умений и опыта
творческое мышление
рассудок
разум
образовательный процесс.

description: Актуальное требование современного общественного развития – глубокий анализ и выработка новой парадигмы образования, где на смену эмпиризму должна прийти, наконец, диалектика как теория и метод мышления. Статья содержит критический анализ компетентностного подхода, навыков как основных требований официальных документов в сфере образования.
Obesity genes: So close and yet so far...
Creators: name: Pomp, D.
name:  Mohlke, K.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Little is known about genetic variants that predispose individuals toward leanness or fatness. This minireview highlights recent advances in the study of human populations, animal models and synergistic efforts as described by De Luca and colleagues in BMC Genetics, which are beginning to harvest low-hanging fruit in the search for obesity genes.
title: 'Not cut out for prison' : Depriving children of their childhood
Creators: name: Lightowler, Claire
name: Adamson, Bruce
name: Galli, Maria
Publisher: name: Strathprints - University of Strathclyde
Year: 2021

description: Children in Scotland continue to be deprived of their liberty in prison like settings. The majority of these children have not been convicted or sentenced, known as being on remand. In 2020 the proportion of children in a young offenders' institution or prison has further increased, with additional concerns for those experiencing remand during the COVID-19 pandemic. This article explores the data about remand and the human rights experiences of children on remand. We also reflect on why such a high proportion of children who have not been tried or have not been convicted are deprived of their liberty in Scotland.
ОСОБЕННОСТИ ОТЧЕТНОГО КОНЦЕРТА В УСЛОВИЯХ ТВОРЧЕСКОЙ СТУДИИ
Creators: name: Н. Е. Попова
name: А. А. Букминов
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: отчетный концерт
значение отчетных концертов
причины стресса юных артистов
методики и методы музыкального образования.

description: В статье анализируется деятельность коллективов музыкальных студий и подготовка обучающихся к отчетному концерту. Особое внимание уделено форме отчетного концерта, обмету опытом, навыку выступлений юных артистов перед публикой. Кроме того, анализируются возможные стрессовые состояния артистов в результате непредвиденных обстоятельств. Для преодоления сценического волнения и успешности проведения концерта даются авторские советы и предлагаются некоторые методики и методы музыкального образования.
Copyright, Software Licenses and Python
Creators: name: Schlauch, Tobias
Publisher: name: Zenodo
Year: 2022
Subjects: copyright
software-licenses
python
reuse-software

description: In this talk, I give an overview about copyright, software licenses, and what general aspects to consider if you publish an open source software package. On this basis, I consider practical aspects in context of Python such as tools to find out license information of your third-party libraries. Particularly, I will introduce REUSE which provides a standardized approach to annotate copyright and license information to your source code repository. The talk has been held at the Python User Group Berlin.
Questionnaire on the Concept of Disability (CoD). Version 0.3
Creators: name: Gebhardt, Markus
name: Schurig, Michael
name: Suggate, Sebastian
name: Scheer, David
name: Diehl, Kirsten
name: Melzer, Conny
name: Schröter, Anne
name: Förster, Magdalena
name: Schmid, Andrea C.
name: Link, Pierre-Carl
name: Roos, Stefanie
name: Capovilla, Dino
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: models of disability, disability, inclusive education, teacher training, concepts of disability, questionair
subject: 370 Erziehung, Schul- und Bildungswesen

description: The term disability is a construct that has historically evolved. Depending on perspective, zeitgeist and context, there have been different definitions of the term disability. This questionnaire utilizes the categories of disability that are commonly used in the scientific discourse in the field of special needs education in Germany, i.e. the individual-medical, social, systemic and cultural concepts of disability. The questionnaire uses closed and open questions to assess peoples concepts of disability in terms of these four categories. In the first instance, it is meant to provide all persons active in the fields of special needs education with dialogic access to their own concepts of the term disability to support detached reflection. Second, insights into the quality of teacher education and areas for potential improvement can be garnered with regards to students’ concepts of disability. The questionnaire includes five open and 25 closed questions. The scale of the individual-medical concept consists of six questions, while the scales of the systemic, social and cultural concepts comprise seven, five and, again, seven questions. The categories and concepts are discussed in an open, joint research process and their operationalization in the questionnaire is constantly being refined, which is why this is the third version of the questionnaire. All items and open questions of the questionnaire are specified hereafter. All data can be found in the OSF project, see: Version 0.1: https://osf.io/dm4cs/ Version 0.2: https://osf.io/y5egu/ Version 0.3: https://osf.io/j76t3/
description: Version 0.3
ОСОБЕННОСТИ САМОСТОЯТЕЛЬНЫХ ЗАНЯТИЙ ДЕВУШЕК В ПРОЦЕССЕ ФИЗКУЛЬТУРНО-СПОРТИВНОЙ ДЕЯТЕЛЬНОСТИ
Creators: name: О. А. Сбитнева
name: Д. Н. Прянишникова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: физическая культура и спорт
самостоятельные занятия
девушки
здоровье
физические упражнения
респонденты
мотивы.

description: В статье рассматриваются особенности самостоятельных занятий девушек. Раскрывается эффективность физической культуры и спорта для всестороннего и гармоничного развития личности. Рассмотрены анатомо-физические особенности девушек. Даны рекомендации по подбору упражнений с учетом особенностей женского организма. Представлены наиболее распространенные направления для занятий девушек. Предложена программа тренировок для самостоятельных занятий. Даны рекомендации по составлению индивидуального комплекса занятий. Проведено анкетирование с целью отношения девушек к физической культуре и спорту. По результатам опроса анализируется значение физической культуры и спорта.
Analysis of adaptive walks on NK fitness landscapes with different interaction schemes
Creators: name: Nowak, Stefan
name: Krug, Joachim
Publisher: name: arXiv
Year: 2015
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Fitness landscapes are genotype to fitness mappings commonly used in evolutionary biology and computer science which are closely related to spin glass models. In this paper, we study the NK model for fitness landscapes where the interaction scheme between genes can be explicitly defined. The focus is on how this scheme influences the overall shape of the landscape. Our main tool for the analysis are adaptive walks, an idealized dynamics by which the population moves uphill in fitness and terminates at a local fitness maximum. We use three different types of walks and investigate how their length (the number of steps required to reach a local peak) and height (the fitness at the endpoint of the walk) depend on the dimensionality and structure of the landscape. We find that the distribution of local maxima over the landscape is particularly sensitive to the choice of interaction pattern. Most quantities that we measure are simply correlated to the rank of the scheme, which is equal to the number of nonzero coefficients in the expansion of the fitness landscape in terms of Walsh functions.
description: 29 pages, 9 figures