cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Multiparametric MRI (mpMRI) in planning for high precision external beam radiotherapy for prostatic malignancies
Creators: name: Balaji, Ravikant
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Genital / Reproductive system male
subject: Oncology
subject: Radioprotection / Radiation dose
subject: MR-Diffusion/Perfusion
subject: MR-Functional imaging
subject: MR-Spectroscopy
subject: Stereotactic radiotherapy
subject: Computer Applications-Detection, diagnosis
subject: Intensity Modulated Radiotherapy (IMRT)
subject: Radiotherapy techniques
subject: Dosimetric comparison
subject: Image guided radiotherapy

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate the use of multiparametric prostate MR imaging in dose escalation for intermediate to high grade...
Structural behaviour and design criteria of under-attack cable-supported foorbridges
Creators: name: Georgiadis, Konstantinos
Publisher: name: Imperial College London
Year: 2020

description: Under-deck cable-supported footbridges are slender and effective structures comprising of cables located underneath the deck. They can be sorted into under-deck cable-stayed (UDCS), under-deck suspension (UDS) and stress-ribbon (SR) footbridges. All of them promote the axial behaviour and reduce the amount of required construction materials. In addition, to their high structural efficiency and sustainability they also possess aesthetic and construction advantages compared to conventional footbridges for covering medium spans. Nevertheless, they become more prone to vibrations that can be activated from the passage of pedestrians during service. In the present work, the dynamic response of UDCS, UDS, and SR footbridges under pedestrian loading in service was examined in detail. Due to the shortcomings of the current codes of practice to represent realistically human-induced vibrations, a stochastic pedestrian load model was implemented. This model simulates the actions induced by individuals, taking into account the inter-subject and intra-subject variability as well as the pedestrian-structure and pedestrian-pedestrian interaction. The pedestrian load model was applied to representative UDCS, UDS and SR benchmark footbridges in order to investigate their dynamic response. The effects of different sources of non-linearities were examined. As for all the benchmark footbridge configurations, when designed to fulfil only ultimate limit states, the acceleration response was found unsatisfactory, yielding to minimum comfort for their users, extensive parametric studies were carried out aiming to find critical design parameters able to improve their dynamic behaviour. Based on the investigation of the benchmark configurations and the parametric studies a set of comprehensive design criteria and recommendations for UDCS, UDS, and SR footbridges were proposed. For all those cases, decreasing the deck slenderness was found the most cost-effective way to improve the dynamic response and increase users’ comfort within appropriate design limits.
Suspicion in consumer choice: theoretical concepts and new empirical evidence
Creators: name: Panigyraki, Artemis
Publisher: name: Imperial College London
Year: 2019

description: The present dissertation consists of three empirical papers, which focus on consumer suspicion as a concept and how it can be overcome with numerical brand claims. In contrast to previous research that predominantly looked at suspicion in a dichotomous fashion, overlooking different levels of intensity, this thesis investigates suspicion in a more empirically fine-grained way. Considering three levels of intensity of suspicion enables a novel finding: That suspicion can lead to positive outcomes, such as increased willingness to purchase. Drawing from research on number cognition, this thesis shows when, how, and which type of numerical brand claim is most instrumental in triggering purchase behaviour in the context of green consumption, a context which is prone to consumer suspicion.
title: Is this viral encephalitis? - A pictorial review of common and uncommon viral CNS infections.
Creators: name: Perothayil, Naajia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: Diagnostic procedure
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to: To enumerate various viral pathogens infecting brain. To revisit the imaging spectrum and MRI features of viral...
Giovani, studenti e public history. Introduzione
Creators: name: Pavone, Sabina
Publisher: name: S. Pavone, Giovani, studenti e public history. Introduzione, «Il capitale culturale», 2020, n. 22, pp. 13-20
Year: 2020

description: Nell’introdurre i saggi contenuti nella sezione monografica Giovani, studenti e public history, la curatrice ricorda la sede originaria dei contributi, presentati durante la III Settimana di Eccellenza del Dipartimento di Scienze della formazione, dei beni culturali e del turismo dell’Università di Macerata. Sottolinea poi l’importanza nella costruzione di progetti di public history della collaborazione di figure diverse: docenti universitari, docenti delle scuole, istituzioni culturali, professionisti. Ricorda infine come proprio il formarsi di competenze multidisciplinari all’interno dei corsi di Beni culturali e turismo possa costituire un’opportunità per gli studenti che siano interessati alla professione di public historian.
description: In introducing the essays contained in the monographic section Giovani, studenti e public history, the curator recalls the original location of the contributions, presented during the III Week of Excellence of the Department of Education, Cultural Heritage and Tourism of the University of Macerata. Then she underlines the importance of the collaboration among different figures (university professors, teachers, cultural institutions, professionals) in the construction of public history projects. Finally, she recalls how the formation of multidisciplinary skills within the courses of Cultural Heritage and Tourism can constitute an opportunity for students who are interested in the profession of public historian.
Cohesin alters immune response gene expression primarily by transcriptional burst frequency modulation
Creators: name: Robles Rebollo, Irene
Publisher: name: Imperial College London
Year: 2020

description: Transcription is an intermittent process that occurs in bursts. The frequency and the number of messenger RNAs (mRNAs) produced by these bursts determine expression levels and shape cell-to-cell variability. Burst dynamics are modulated by productive encounters between enhancers and promoters, which can be facilitated by the cohesin complex through loop ex-trusion. In experimental systems, cohesin deficiency disrupts cell-type-specific expression pro-grams more severely than constitutive gene expression. Cohesin loss of function increases the self-renewal of hematopoietic progenitor stem cells (HPSCs), and cohesin-related mutations are frequent in cancers, such as AML. Cohesin defects in human AML, mouse HSPC and mature myeloid cells lead to a transcriptional state characterised by the reduced expression of inducible inflammatory genes and the elevated expression ofMyctargets and oxidative phosphorylation (OXPHOS) genes. In this thesis, I combine RNAseq, GROseq, scRNAseq, and smFISH to explore how cohesin depletion affects transcriptional parameters at steady-state and during cell-state transitions. Using primary macrophages as a model system, I find that loss of cohesin alters the dynamics of transcriptional bursts without measurably increasing cell-to-cell variability in scRNAseq. I show that expression changes triggered by LPS are primarily orchestrated through the modulation of burst frequencies, and this modulation is blunted in cohesin-deficient macrophages. An increase in burst frequency can have consequences not just for individual cells, but also for their neighbours. Specifically, the frequency of transcriptionalIfnb1bursts determines the number of cells that produceIfnb1-encoded type I interferon (IFN), which through paracrine signalling can alter IFN-dependent expression in neighbouring cells. Co-culture with cohesin-deficient macrophages reduces LPS-induced gene expression in wildtype (WT) macrophages, indicating that cohesin defects can buffer inflammatory responses and impair cell-state transitions due to the defective control of burst frequencies. I speculate that these features contribute to the somatic selection of cohesin mutations in cancer.
title: The impact of aortic valve replacement (AVR) in right ventricular remodelling in patients with severe aortic stenosis
Creators: name: Martins, Paula
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Radiographers
subject: Cardiac
subject: MR
subject: Segmentation
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Aortic valve replacement (AVR) is the most effective way to treat aortic valve stenosis (AS), and to potentially revert ventricular dysfunction 1,2 . The outcomes of AVR on the left ventricular function have improved over the last decade, and have...
Identifying effective multiple spreaders by coloring complex networks
Creators: name: Zhao, Xiang-Yu
name: Huang, Bin
name: Tang, Ming
name: Zhang, Hai-Feng
name: Chen, Duan-Bing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: How to identify influential nodes in social networks is of theoretical significance, which relates to how to prevent epidemic spreading or cascading failure, how to accelerate information diffusion, and so on. In this Letter, we make an attempt to find \emph{effective multiple spreaders} in complex networks by generalizing the idea of the coloring problem in graph theory to complex networks. In our method, each node in a network is colored by one kind of color and nodes with the same color are sorted into an independent set. Then, for a given centrality index, the nodes with the highest centrality in an independent set are chosen as multiple spreaders. Comparing this approach with the traditional method, in which nodes with the highest centrality from the \emph{entire} network perspective are chosen, we find that our method is more effective in accelerating the spreading process and maximizing the spreading coverage than the traditional method, no matter in network models or in real social networks. Meanwhile, the low computational complexity of the coloring algorithm guarantees the potential applications of our method.
description: 6 pages, 6 figures
title: Pleural pathology – a primer for radiologists
Creators: name: Zhong, Jim
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Lung
subject: Mediastinum
subject: Respiratory system
subject: CT
subject: PET-CT
subject: Digital radiography
subject: Sampling
subject: Diagnostic procedure
subject: Biopsy
subject: Pathology
subject: Cancer
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: We aim to provide an educational pictorial review with the aid of multi-modality imaging to: - illustrate pleural anatomy and the relationship to important intra-thoracic structures. - provide a structured approach to benighandmalignantpathologies...
In vivo function of the immunoreceptor NKG2D in intestinal inflammation and tumorigenesis
Creators: name: Curio, Sophie
Publisher: name: Imperial College London
Year: 2020

description: NKG2D is an activating receptor expressed on various immune cells. Engagement of NKG2D through its ligands, which are expressed mainly on transformed or stressed cells, typically leads to target cell death, thereby making it a potent player in anti-tumor immunity. We recently identified a pro-tumor role for NKG2D in the context of inflammation-driven cancer, where sustained expression of NKG2D and its ligands resulted in exacerbated disease in a model of hepatocellular carcinoma NKG2D has been implicated in various inflammatory disorders, where aberrant expression and activation of NKG2D-expressing effector cells can lead to tissue damage and autoinflammation. The intestine is of particular interest, as NKG2D ligands have been shown to be constitutively expressed on healthy epithelial cells. Further, NKG2D has been implicated in human inflammatory bowel disease. The role of NKG2D in colorectal cancer is unclear, but being an inflammation-driven cancer, we hypothesized that NKG2D would contribute and exacerbate intestinal tumorigenesis. In this thesis, we show that NKG2D expression is elevated on various immune cells in the healthy murine intestine and confirm that germline deletion of NKG2D does not impact intestinal health at steady state. We further demonstrate that NKG2D exacerbates inflammation-driven intestinal cancer and identify CD8+ T cells and γδT cells as the main drivers of disease. We confirm that IFNγ-producing CD8+ T cells preferentially accumulate in intestinal tumors in an NKG2D-dependent manner and reveal a novel role for PD-1+ γδT cells in driving disease. We show that disease progression is associated with mild changes in the microbiota, but is independent of NKG2D expression. Lastly, we investigate the function of NKG2D in two models of intestinal inflammation and show that NKG2D is dispensable for the immune response in sterile colitis. Using a model of infectious-induced colitis, we show that NKG2D deficiency delays colonization of pathogenic bacteria, but does not influence the severity of inflammation. Together, we provide valuable insight into NKG2D-mediated immunity in the setting of intestinal homeostasis, tumorigenesis and inflammation.
Vortices in Bose-Einstein Condensates
Creators: name: Alex-Duduyemi, Omofolarin
Publisher: name: Imperial College London
Year: 2019

description: This thesis surveys aspects of the very broad topic of vortex dynamics in Bose-Einstein condensates. The Gross-Pitaevskii equation (GPE) is an important and popular tool in this regard, and we discuss a number of its properties which are relevant to the study of vortex dynamics. Using the GPE, we explore the dynamics of point vortices in Bose-Einstein condensates, writing hydrodynamic relations we have not encountered elsewhere in the literature. For incompressible condensates, we pay particular attention to discussions of the structure of the Hamiltonian system, and we revisit the topic of linear stability analysis for a steadily rotating, regular polygon of vortices. Furthermore, geometric mechanics is a powerful tool in the study of fluid dynamics, and we make use of the language of geometric mechanics, in particular the Lie derivative, to gain insights into some of the consequences of describing superfluid dynamics using the GPE. We have not encountered the relations we have derived as a result of this effort elsewhere in the literature. The topics of vortex formation, general approaches to describing vortex dynamics and phonon emission are also discussed.
title: Accuracy of multi-parametricMRI sequences in bladder cancer staging
Creators: name: Palacios Miras, Carmelo
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Cancer
subject: Diagnostic procedure
subject: MR-Diffusion/Perfusion
subject: MR
subject: Urinary Tract / Bladder
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Bladder cancer is the most frequent type of tumor of the urinary tract , the fourth most common cancer in males and the tenth most common cancer in females [1]. It has a high recurrence rate, so it necessitates long-term follow-up after initial...
Identification of transcription factor targets, gene expression profiles and accessible chromatin regions in the Caenorhabditis elegans epidermis using targeted DamID
Creators: name: Katsanos, Dimitrios
Publisher: name: Imperial College London
Year: 2020

description: Development is an exceptionally complex process that is performed with exquisite control. A series of developmental programmes allow the orchestrated and tightly-regulated deployment of the genomic information, governing events like cell division, cell fate maintenance and differentiation. Understanding the complete regulatory states that instruct a selective decoding of the genome capable of bringing about morphogenetic events is central to developmental biology. Among all cells, stem cells maintain the potential to produce cells that undergo transitions in developmental trajectories and thus are particularly interesting. In this study, I have used the postembryonic development of the Caenorhabditis elegans epidermis driven by the stem cell-like seam cells, to begin exploring the gene regulatory network, transcriptional states and epigenomic regulation involved in cell fate patterning. To that end, I have adapted and present here the first application of the targeted DamID (TaDa) methodology in C. elegans, for assaying protein-DNA interactions, to use as a single technique in approaching all of the above objectives. I show that TaDa requires little starting material, is reproducible and tissue-specific. Using TaDa I identify targets for the transcription factors LIN-22 and NHR-25 that propose new biological functions for these regulators in epidermal development. I acquire gene expression profiles for the seam cells and hypodermis that lead to the discovery of novel transcription and chromatin factors, as well as new miRNAs. Finally, I produce the first cell-type-specific chromatin accessibility maps in C. elegans for the seam cells and hypodermis and use them to identify tissue-specific enhancers. These findings expand our knowledge of the mechanisms underlying fate decisions in epidermal patterning and provide a proof-of-concept for the application of TaDa in C. elegans.
Calyxochaetus fortunatus
Creators: name: Runyon, Justin B.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Calyxochaetus
Calyxochaetus fortunatus

description: Calyxochaetus fortunatus species group
Diagnosis. The C. fortunatus species group is defined by males having fore tarsomere 1 very short, a swollen fore tibia (Figs 82–86), and fore tarsomere 2 with slender distally directed anterior seta near apex (Fig. 83). Males have the posterior wing margin weakly to strongly lobed and/or excavated (Figs 88–91) and with eyes contiguous or nearly contiguous (<1 ommatidium wide) below antennae. Females have a relatively narrow face that is subequal to postpedicel width. Scutellum without distinct blue-violet reflections (sometimes weakly blue-violet).
description: Published as part of Runyon, Justin B., 2024, Revision of the genus Calyxochaetus Bigot (Diptera: Dolichopodidae: Sympycninae), pp. 1-74 in Zootaxa 5539 (1) on page 37, DOI: 10.11646/zootaxa.5539.1.1, http://zenodo.org/record/14240426
Quartz crystal microbalance based histidine sensor
Creators: name: Sönmezler, Merve
name: Özgür, Erdoğan
name: Yavuz, Handan
name: Denizli, Adil
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Herein, quartz crystal microbalance (QCM) biosensor is prepared for the detection of l-histidine by attachment of l-histidine imprinted poly(EGDMA-MAH/Cu(II)) nanoparticles on QCM electrode. The imprinted nanoparticles with the size of 86.43 nm were synthesized via miniemulsion polymerization reaction. Prepared QCM sensors were characterized with ellipsometer, contact angle measurements and FTIR. The thickness measurements demonstrated that the particle thin films were almost monolayer. l-histidine solutions with a concentration range between 6.44 μM and 225.6 μM were introduced to QCM system to determine the adsorption kinetics. Selectivity of the l-histidine imprinted nanoparticles were examined using d-histidine and l-tryptophan as competitor molecules. l-histidine imprinted QCM biosensors was also used for RNAase, lysozyme, cytochrome-C and BSA to investigate the competitive adsorption of surface histidine exposed proteins.
Does Dysbiosis in Gut Microbiota During Infancy Contribute to Psychological Disorders in Adult Life?
Creators: name: Gama, Lívia Cavalcanti de Morais
name: Brentani, Helena Paula
name: Setubal, João Carlos
Publisher: name: Zenodo
Year: 2023
Subjects: 16s rRNA
Anorexia Nervosa
Bipolar Disorder
Gut-brain Axis

description: The human adult gastrointestinal tract is a complex and diverse ecosystem that harbors a multitude of commensal microorganisms, distributed among more than 1,000 different species. The gut microbiota plays an important role in an individual's immunological, metabolic, and neurological systems, among others. The nervous system and gastrointestinal tract communicate through a bidirectional network of signaling pathways called the gut-brain axis (GBA). In the last several years it has also become evident that gut bacteria can affect the physiology and inflammation of the central nervous system (CNS). However, some conditions can cause a disruption in the gut microbiome and result in dysbiosis, which can be defined as "a reduction in microbial diversity and a combination of the loss of beneficial bacteria [...] and a rise in pathobionts (symbiotic bacteria that become pathogenic under certain conditions)[...]". Infancy (0 to 3 years) is an important phase subject to multiple factors that modulate the gut microbiota, and dysbiosis during this period may have a link to the development of neuropsychiatric disorders in the long term. Recent research indicates that the growth of neurons is intricately linked to the evolution of gut microbiota. To investigate the correlation between gut microbiota and mental disorders, 15 publicly available 16S rRNA datasets were chosen. These datasets come from 8 studies that determined the intestinal microbiota in infants aged 0 to 3 years that present dysbiosis and 7 in adults (from 18 years of age) with anorexia nervosa and bipolar disorder. We will compare gut microbiota profiles of the datasets using the qiime2 platform. We assume that in each selected dataset there is always a control group and a patient group. Our focus will be on groups of bacteria that can be classified in the following two categories, in terms of statistically significant differential abundance: (1) Increased in patients and (2) Decreased in patients. We plan to look for taxa that are consistently part of one of these two categories in different studies, especially when the taxon recurrence includes at least one infant dataset and at least one adult dataset. We will also check for inconsistencies, which are taxa that appear differentially represented in category (1) in some datasets and in category (2) in other datasets. Preliminary results show that the genus Clostridium is in category (1).
Velocities hasten to tell us about the Universe
Creators: name: Ma, Yin-Zhe
name: Scott, Douglas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The peculiar velocities of galaxies are driven by gravity, and hence hold the promise of probing details of how gravity forms structures. In particular it is possible to constrain cosmological parameters and to test extensions to the standard model, such as modifications to the theory of gravity or the existence of primordial density perturbations which are non-Gaussian. This constraining power has been frustrated by systematic effects, but we appear to be entering an era when velocity measurements may finally be living up to their promise.
description: A review article of 6 pages and 8 figures
title: Design of the open CT derived FFR registry
Creators: name: Coenen, Adriaan
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Cardiac
subject: Computer applications
subject: CT-Angiography
subject: Computer Applications-Detection, diagnosis
subject: Diagnostic procedure
subject: Arteriosclerosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Recently we have seen the introduction of several different CT-derived FFR (fractional flow reserve) applications. Most have in common that they rely on a CT coronary angiography (CTA) dataset, sometimes combined with several patient specific...
RETRACTED ARTICLE: The value of FGF9 as a novel biomarker in the diagnosis of prostate cancer
Creators: name: Cui, Genggang
name: Shao, Mingming
name: Gu, Xingzhou
name: Guo, Hongbo
name: Zhang, Shiqing
name: Lu, Jianlei
name: Ma, Hongbin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Cell Biology
Biotechnology
Cancer
Science Policy

description: We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Genggang Cui, Mingming Shao, Xingzhou Gu, Hongbo Guo, Shiqing Zhang, Jianlei Lu & Hongbin Ma (2019) The value of FGF9 as a novel biomarker in the diagnosis of prostate cancer. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 2241–2245, DOI: 10.1080/21691401.2019.1620250 It has come to our attention that the full authorship list and affiliations for this manuscript, including the study site and ethics committee, were changed after the article was submitted. We have contacted the authors for an explanation, but we have not received a response within the requested timeframe. As determining authorship and the location of where the research was conducted is core to the integrity of published work, we are therefore retracting the article. The authors listed in this publication have been sent notification. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
title: A pictorial review of uncommon cervical tumours on MRI
Creators: name: Fawkes, Amy
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Education
subject: MR
subject: Genital / Reproductive system female

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review cases of unusal cervical cancer at...
Hydrogen Combustion Engines as a Key Part of Reaching Net Zero
Creators: name: Wang, Xinyan
name: Zhao, Hua
Publisher: name: Brunel University London
Year: 2024
Subjects: classificationCode: 440704
subject: Environment policy
classificationCode: 370201
subject: Climate change processes

description: Brunel Public Policy brief: hydrogen combustion engines produce zero carbon and ultra-low NOx emissions with superior engine thermal efficiency compared with fossil fuel engines. Compared with hydrogen Fuel Cells (FC), they do not require rare materials or purified hydrogen, and are much cheaper and more reliable. They can be manufactured using existing capabilities and supply chains, making hydrogen combustion engines a sustainable and affordable candidate to decarbonise transport.
title: The diagnosis and managment of endoleaks in interventional radiology
Creators: name: Kelly, Brendan
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Education and training
subject: Arthrography
subject: CT-Angiography
subject: Catheter arteriography
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of thiseducational exhibit is to : Outline the imaging findings on post EVAR CT angiography that suggest an endoleak. Illustrate the grading system of endoleaks. Outline managment options for each grade of...
Metadata for the KM3NeT CORSIKA simulations
Creators: name: Piotr Kalaczyński
Publisher: name: Zenodo
Year: 2023
Subjects: CORSIKA, MC, simulation, CR, cosmic ray

description: This resource contains the metadata for CORSIKA MC productions for KM3NeT.
description: Funded by the National Science Centre (NCN) under the project "Measurement of muon flux with KM3NeT-ARCA and KM3NeT-ORCA detectors" (grant number 2020/37/N/ST2/03389)
Platforms for delivery of macromolecules to sites of DNA double-strand break repair
Creators: name: Cao, Zhen
name: Goyal, Deepika
name: Meiler, Steffen E.
name: Zhou, Yunfeng
name: Dynan, William S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Double-strand break (DSB) repair foci are important therapeutic targets. Here we describe platforms for delivery of macromolecules, nanomaterials and nanomedicines to repair foci. The strategy is based on the high affinity of the human 53BP1 protein for modified chromatin present at sites of DNA damage. As proof of concept, we created, expressed, and purified an engineered fragment of 53BP1 and coupled it to fluorescent streptavidin, a model cargo with no intrinsic affinity for repair foci. This binary complex was in turn coupled to the iron carrier protein, transferrin, which engages a high-affinity cell surface receptor. In a different version of the complex, transferrin was omitted and a protein transduction domain was incorporated directly into the primary structure of the 53BP1. These complexes were efficiently taken up into human osteosarcoma cells and synchronously released from endocytic vesicles by brief exposure to far-red light in the presence of the photosensitizer, disulfonated aluminum phthalocyanine. Upon release, the streptavidin cargo entered the nucleus and was recruited to repair foci. 53BP1-based platforms provide a method for targeted, temporally controlled delivery of macromolecular agents to sites of double-strand break repair. With the delivery platforms, we are capable to visualize, modify and redirect DSB repair pathways by coupling various nanomaterials to study machinery or manipulate for therapy purpose in the future.
Metadata for the KM3NeT CORSIKA simulations
Creators: name: Piotr Kalaczyński
Publisher: name: Zenodo
Year: 2023
Subjects: CORSIKA, MC, simulation, CR, cosmic ray

description: This resource contains the metadata for CORSIKA MC productions for KM3NeT.
description: Funded by the National Science Centre (NCN) under the project "Measurement of muon flux with KM3NeT-ARCA and KM3NeT-ORCA detectors" (grant number 2021/41/N/ST2/01177)
title: O2-O3 chemiodiscolysis: how much, how long? Retrospective outcome evaluation of different treatment sessions in partially-responder patients.
Creators: name: Bruno, Federico
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Quality assurance
subject: Technical aspects
subject: Cost-effectiveness
subject: MR
subject: CT
subject: Neuroradiology spine
subject: Interventional non-vascular

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Low back pain is one of the most common and important clinical, social and public health problems affecting adult population worldwide. In up to 50% of cases, there are associated sciatic symptoms, which 90% of the time are generated by disc...
Metadata for the KM3NeT CORSIKA simulations
Creators: name: Kalaczyński, Piotr
Publisher: name: Zenodo
Year: 2023
Subjects: CORSIKA, MC, simulation, CR, cosmic ray

description: This resource contains the metadata for CORSIKA MC productions for KM3NeT.
description: Funded by the National Science Centre (NCN) under the project "Measurement of muon flux with KM3NeT-ARCA and KM3NeT-ORCA detectors" (grant number 2020/37/N/ST2/03389)
Reverses of the Young inequality for matrices and operators
Creators: name: Bakherad, Mojtaba
name: Krnic, Mario
name: Moslehian, Mohammad Sal
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 47A60, 47A30, 15A60

description: We present some reverse Young-type inequalities for the Hilbert-Schmidt norm as well as any unitarily invariant norm. Furthermore, we give some inequalities dealing with operator means. More precisely, we show that if $A, B\in {\mathfrak B}(\mathcal{H})$ are positive operators and $r\geq 0$, $A\nabla_{-r}B+2r(A\nabla B-A\sharp B)\leq A\sharp_{-r}B$ and prove that equality holds if and only if $A=B$. We also establish several reverse Young-type inequalities involving trace, determinant and singular values. In particular, we show that if $A, B$ are positive definite matrices and $r\geq 0$, then $\label{reverse_trace} \mathrm{tr}((1+r)A-rB)\leq \mathrm{tr}|A^{1+r}B^{-r} |-r(\sqrt{\mathrm{tr} A} - \sqrt{\mathrm{tr} B})^{2}$.
description: 15 pages, to appear in Rocky Mountain J. Math
title: Renal Pseudotumors: Features that help differentiate them from a real neoplasm.
Creators: name: Brunie, Francois Xavier
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Contrast agent-intravenous
subject: Biopsy
subject: Ultrasound-Colour Doppler
subject: MR
subject: CT
subject: Anatomy
subject: Kidney
subject: Abdomen
subject: Infection
subject: Inflammation
subject: Arteriovenous malformations

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Know the different entities that may manifest as a renal pseudotumor. Describe the radiological characteristics that can help us to differentiate them from a real...
The value of FGF9 as a novel biomarker in the diagnosis of prostate cancer
Creators: name: Cui, Genggang
name: Shao, Mingming
name: Gu, Xingzhou
name: Guo, Hongbo
name: Zhang, Shiqing
name: Lu, Jianlei
name: Ma, Hongbin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Background:Fibroblast growth factor 9 (FGF9) is reported to be associated with the pathogenesis of cancers. However, its clinic significance in prostate cancer (PCa) had not yet to be elucidated. The aim of this study was to investigate the diagnostic value of FGF9 in PCa. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analyses were used to detect the expression of serum FGF9 at mRNA and protein level in 90 PCa patients, 48 prostatic benign diseases (PBD) patients and 30 normal individuals. The association between FGF9 and clinicopathological features was determined by Chi-square test. Receiver-operator characteristic (ROC) was established to evaluate the diagnostic performance of FGF9 and PSA. Results: Serum FGF9 expression was significantly elevated in PCa patients (p < .001) and was obviously decreased after surgery (p < .001). FGF9 expression was also associated with lymph node metastasis (p = .010). The diagnostic value of FGF9 was higher than the conventional tumor marker PSA with a AUC of 0.846 combined with a sensitivity of 83.3% and a specificity of 81.1%. Conclusions: Serum FGF9 may be employed as a potential diagnostic biomarker of PCa.
Isolation and genomic characterization of Klebsiella pneumoniae phages with potential for therapeutic application
Creators: name: Azevedo, Maria Joana Nunes de
name: Martins, Layla Farage
name: Pereira-Santos-Junior, Ariosvaldo
name: Rossi, Fernando Pacheco Nobre
name: da Silva, Aline Maria
Publisher: name: Zenodo
Year: 2023
Subjects: Klebsiella pneumoniae
Antibiotic Resistance
Bacteriophage
Metagenomics

description: Viruses that use bacteria as hosts are called bacteriophages or simply phages. In the lytic cycle, after replication of the phage genetic material and assembly of the particles, the viral progeny is released by complete lysis of the bacterial cell. Phages that propagate through the lytic cycle (lytic phages) have been considered a promising strategy for the biological control of infections by multidrug-resistant bacteria, including carbapenem-resistant Klebsiella pneumoniae (CRKP). CRKP strains have emerged as a serious public health problem worldwide in the last 10 years, and therapeutic options are limited. The main objectives of this project are: (1) to analyze the genomes of 4 clinical isolates of CRKP; (2) to use these strains to isolate lytic phages against CRKP; (3) to characterize the genomes of the isolated phages and evaluate their therapeutic potential in an animal model; and (4) to prospect for K. pneumoniae phage genomes in metagenomic data from the environmental sample used to isolate the phages. The 4 CRKP isolates were obtained from hospitalized patients at the Hospital das Clínicas of the USP School of Medicine. The genomes of these isolates were sequenced using MiSeq-Illumina platform prior to the start of this project and the data obtained was then used to assemble and annotate the genomes, determine the ST (Sequence Type), capsular type, resistance genes and identify plasmids. One of the isolates (K81-498) was chosen as the host strain for phage isolation. To this end, water samples were collected from the Pirajussara stream inside USP Butantan campus and used as a source for phage isolation. So far, 8 phages have been isolated from lysis plaques observed in the K81-498 culture. These phages will be purified for microbiological and genomic characterization. Both the phage DNA and the total DNA from the water samples will be extracted and sequenced on the Illumina platform. Our expectation is that within a few months we will have the sequencing data available to follow up on the project's objectives, which will enable the genomic characterization of the isolated phages for potential clinical use in the treatment of CRKP infections. At the same time, we will also be recovering phage genomes from the environmental sample used to isolate the phages from K. pneumoniae.
Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity
Creators: name: Krishnan, Vennila
name: Loganathan, Chitra
name: Thayumanavan, Palvannan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Inorganic Chemistry
subject: 60506 Virology

description: s-allyl glutathione (SAG) an analogue of glutathione is explored for its antioxidative and liver protection property in recent years. Selenium nanoparticles (Sh-SeNPs) were synthesized using medicinal plant Spermacoce hispida and conjugated with SAG (SAG-Sh-SeNPs). SAG-Sh-SeNPs and Sh-SeNPs were characterized using by Fourier transform infrared spectroscopy, Transmission electron microscopy, Energy dispersive X-ray analysis, X-ray diffraction analysis and zeta potential analysis. SAG-Sh-SeNPs and Sh-SeNPs were evaluated against acetaminophen (APAP)-induced liver and kidney injury in rat. Pretreatment of NPs attenuated the APAP toxicity-induced elevation of kidney and liver injury markers in the blood circulation. Histological observation showed that NPs pretreatment protected the morphology of liver and kidney tissue. SAG-Sh-SeNPs showed enhanced protection against APAP toxicity in comparison to Sh-SeNPs due to synergistic effect of SAG and Sh-SeNPs. SAG-Sh-SeNPs protected the liver and kidney against APAP toxicity through reducing oxidative stress, enhancing endogenous antioxidants and protecting mitochondrial functions.
title: US of Foreign Body: Pitfalls, Complications and Differences depending on Composition
Creators: name: Marín Diez, Elena
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Tissue characterisation
subject: Outcomes
subject: Foreign bodies
subject: Localisation
subject: Diagnostic procedure
subject: Computer Applications-Detection, diagnosis
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Digital radiography
subject: Musculoskeletal system
subject: Musculoskeletal soft tissue
subject: Emergency

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe US foreign body imaging findings and features depending on its composition . To quickly and systematically identify the foreign body associated complications . To recognize the main pitfalls found during the USevaluation of foreign...
title: Are preoperative chest x-ray films requested according to accepted clinical criteria? A survey in urban hospitals of the city of Murcia, Spain
Creators: name: Botía González, Carmen
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Quality assurance
subject: Medico-legal issues
subject: Conventional radiography
subject: Management

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The clinical impact of requesting routinary preoperative chest x-rays has been questioned among years. According to current literature, there is no evidence that preoperative chest x-rays have a role to detect cardiopulmonary disease in all types of...
title: Relationship Between Prognostic Factors, Survival With Apparent Diffusion Coefficient in Breast Cancer
Creators: name: Karabulut, Derya
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: It is widely accepted that dynamic contrast enhanced MRI (DCE-MRI) is efficient with diagnosis of breast cancer by reflecting the extent of tumor angiogenesis in recognizing multifocal disease, detecting of cancer in dense breast tissue, determining...
title: Primary hyperaldosteronism: the role of abdominal MSCT in the planning of adrenal venous sampling (AVS)
Creators: name: Drago, Angelica
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Interventional vascular
subject: Abdomen
subject: Computer applications
subject: CT
subject: Catheter venography
subject: CT-Angiography
subject: Catheters
subject: Efficacy studies
subject: Sampling
subject: Blood
subject: Endocrine disorders
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Primary aldosteronism is considered to be the most common cause of secondary hypertension [1]. Idiopathic bilateral adrenal hyperplasia and aldosterone-producing adrenal adenoma are the leading causes of primary aldosteronism. Patients with an...
title: Wilms’ tumor: A case-based Review of Some Rare and Atypical Presentations
Creators: name: BILACHI, LIGIA
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Paediatric
subject: CT
subject: MR
subject: Contrast agent-intravenous
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Wilms' tumor, also known as nephroblastoma, it’s an embryonal renal cancer and one of the most common solid malignant neoplasm in children. It accounts for approximately 90% of all pediatric renal tumors and more than 80% of children are diagnosed...
Platforms for delivery of macromolecules to sites of DNA double-strand break repair
Creators: name: Cao, Zhen
name: Goyal, Deepika
name: Meiler, Steffen E.
name: Zhou, Yunfeng
name: S. Dynan, William
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Double-strand break (DSB) repair foci are important therapeutic targets. Here we describe platforms for delivery of macromolecules, nanomaterials and nanomedicines to repair foci. The strategy is based on the high affinity of the human 53BP1 protein for modified chromatin present at sites of DNA damage. As proof of concept, we created, expressed, and purified an engineered fragment of 53BP1 and coupled it to fluorescent streptavidin, a model cargo with no intrinsic affinity for repair foci. This binary complex was in turn coupled to the iron carrier protein, transferrin, which engages a high-affinity cell surface receptor. In a different version of the complex, transferrin was omitted and a protein transduction domain was incorporated directly into the primary structure of the 53BP1. These complexes were efficiently taken up into human osteosarcoma cells and synchronously released from endocytic vesicles by brief exposure to far-red light in the presence of the photosensitizer, disulfonated aluminum phthalocyanine. Upon release, the streptavidin cargo entered the nucleus and was recruited to repair foci. 53BP1-based platforms provide a method for targeted, temporally controlled delivery of macromolecular agents to sites of double-strand break repair. With the delivery platforms, we are capable to visualize, modify and redirect DSB repair pathways by coupling various nanomaterials to study machinery or manipulate for therapy purpose in the future.
Search for "Ridge" in d+Au Collisions at RHIC by STAR
Creators: name: Li Yi For STAR Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Dihadron correlations are measured in d+Au collisions at 200 GeV by the STAR detector. The correlated yields with uniform background subtraction are studied in high- and low-multiplicity collisions. The effects of multiplicity selection bias on jet-like correlations are discussed. Finite correlated yields are observed on the near-side at large pseudo-rapidity separation in high-multiplicity collisions.