Additional file 1 of Predictors and reproducibility of urinary organophosphate ester metabolite concentrations during pregnancy and associations with birth outcomes in an urban population
Creators: name: Kuiper, Jordan R.
name: Stapleton, Heather M.
name: Wills-Karp, Marsha
name: Xiaobin Wang
name: Burd, Irina
name: Buckley, Jessie P.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Overall within-subject coefficients of variation (%CV) for urinary organophosphate ester metabolite concentration (ng/mL) duplicate samples, median %CV, and range of %CVs. Table S2. Specific gravity-corrected urinary organophosphate ester metabolite concentrations (ng/mL). Table S3. Intraclass correlation coefficients (ICCs) of urinary organophosphate ester metabolite concentrations measured up to three times during pregnancy and incorporating assay variability. Table S4. Repeated measures Pearson correlations between log2-transformed specific gravity-corrected urinary organophosphate ester metabolite concentrations. Table S5. Unadjusted odds ratios or percent differences of specific gravity-corrected urinary organophosphate ester metabolite concentrations. Table S6. Birth outcome and biomarker characteristics of infants included in study. Table S7. Adjusted differences (95% confidence intervals) in birth outcomes per standard deviation increase in visit-averaged urinary organophosphate ester metabolite concentrations estimated using OLS regression models. Table S8. Adjusted joint-exposure effects of OPEs (Ψ) on z-standardized birth outcomes (95% confidence intervals) and expected outcome z-scores at each quartile (Q) of the OPE mixture estimated using quantile g-computation. Table S9. Adjusted differences (95% confidence intervals) in z-standardized cord blood biomarker concentrations per standard deviation increase in covariate-adjusted urinary organophosphate ester metabolite latent factors estimated using structural equation regression models. Figure S1. Multiple-indicators-multiple-causes (MIMIC) model of urinary organophosphate ester metabolite concentrations and infant birth outcomes. Model loadings (λ) and indirect effects (γ) estimated among all 90 women with available urine samples. Associations (β) of the latent factor (F) with birth outcomes estimated using robust full-information maximum likelihood. Model error represented by ε0. Figure S2. OPE metabolite-specific weights indicating proportion contributions to the OPE mixture effect in the negative or positive direction. Shading of bars indicates strength of directional association. Birth length (A), ponderal index (B), gestational age at delivery (C), and birth weight for gestational age (D). Figure S3. Expected birth outcome z-score associated with quartile increases in the OPE mixture. Birth length (A), ponderal index (B), gestational age at delivery (C), and birth weight for gestational age (D).