cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Comparative genomic analyses of Entamoeba species
Creators: name: Wilson, Ian
Publisher: name: University of Liverpool Repository
Year: 2015

description: Amoebiasis is the third-most common cause of mortality worldwide from a disease borne of a parasitic infection. It affects up to 50 million people annually, of which 40,000 to 100,000 cases are fatal. Entamoeba histolytica is an obligate protozoon parasite of humans and is the aetiological agent of the disease. Recent suggestions that other members of the Entamoeba genus are human-infective, and potentially pathogenic, have been investigated here. A draft assembly and annotation of the 25 Mb genome of E. moshkovskii strain Laredo is presented, to which multiple E. moshkovskii strains were mapped. The E. moshkovskii genome was found to be approximately 200 times more variable than that of E. histolytica. Performance of the four-haplotype test revealed that genetic recombination does not seem to occur in E. moshkovskii. As such, it is suggested that it be referred to as a ‘species complex’, rather than an individual species. A comparative genomic analysis of E. histolytica HM-1:IMSS, E. moshkovskii Laredo, E. invadens IP-1 and the avirulent E. dispar SAW760 was performed. Subsequent comparative analyses against members of genera representative of the diversity in the Unikonts clade enabled the identification of orthologous gene families unique to the Entamoeba genus. Analysis of virulence factors within this set revealed that gene families involved in adhesion of amoebic trophozoites to host cells play a key role in the development of invasive amoebiasis. The Gal/GalNAc lectins and members of the BspA family are of particular interest, being present in all analysed species, except for E. dispar. The presence of these key families, plus cysteine proteases, in the E. moshkovskii genome suggests that some sequence types within this species complex may be pathogenic. E. invadens was found to possess larger numbers of more variable genes within many virulence factor families, including the BspA family and the Gal/GalNAc lectins. This suggests that sequence diversity facilitates E. invadens’ polyxenous lifestyle. Finally, a novel species recently isolated from a human faecal sample - E. bangladeshi, strain 8237 – was sequenced. Its genome was assembled using multiple de novo genome assemblers and coding sequences were assembled individually. A combination of all methods tested was found to be beneficial in maximising the number of gene sequences assembled, which is advised as good practice in future similar assemblies. The phylogeny of E. bangladeshi, achieved using the combined assemblies’ outputs suggested that the novel species is human-infective. The work presented here utilised modern comparative genomic techniques to improve understanding of Entamoeba species, their capacity for causing disease and their potential impact upon the epidemiology of amoebiasis.
Role of Multidrug Resistance-Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat
Creators: name: Ferslew, B. C.
name: Brouwer, K. L. R.
name: Kock, K.
name: Bridges, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Hepatic uptake and efflux transporters govern the systemic and hepatic exposure of many drugs and metabolites. Enalapril is a pharmacologically inactive prodrug of enalaprilat. Following oral administration, enalapril is converted to enalaprilat in hepatocytes and undergoes translocation into the systemic circulation to exert its pharmacologic effect by inhibiting angiotensin-converting enzyme. Although the transport proteins governing hepatic uptake of enalapril and the biliary excretion of enalapril and enalaprilat are well established, it remains unknown how hepatically derived enalaprilat translocates across the basolateral membrane into the systemic circulation. In this study, the role of ATP-binding cassette transporters in the hepatic basolateral efflux of enalaprilat was investigated using membrane vesicles. ATP-dependent uptake of enalaprilat into vesicles expressing multidrug resistance–associated protein (MRP) 4 was significantly greater (∼3.8-fold) than in control vesicles. In contrast, enalaprilat was not transported to a significant extent by MRP3, and enalapril was not transported by either MRP3 or MRP4. The functional importance of MRP4 in the basolateral excretion of derived enalaprilat was evaluated using a novel basolateral efflux protocol developed in human sandwich-cultured hepatocytes. Under normal culture conditions, the mean intrinsic basolateral efflux clearance (CLint,basolateral) of enalaprilat was 0.026 ± 0.012 µl/min; enalaprilat CLint,basolateral was significantly reduced to 0.009 ± 0.009 µl/min by pretreatment with the pan-MRP inhibitor MK-571. Results suggest that hepatically derived enalaprilat is excreted across the hepatic basolateral membrane by MRP4. Changes in MRP4-mediated basolateral efflux may alter the systemic concentrations of this active metabolite, and potentially the efficacy of enalapril.
title: Natural immunity to salmonella in humans
Creators: name: Nyirenda, Tonney
Publisher: name: University of Liverpool Repository
Year: 2015

description: Background: Salmonella bacteraemia is an important public health problem in children from sub Saharan Africa (SSA). Understanding what constitutes natural acquired immunity to Salmonella is crucial for the development of Salmonella vaccine. It was hypothesized that natural Salmonella exposure within the GIT and peripheral blood induces the generation of specific-antibodies and T cells and these might provide protection to subsequent Salmonella infection. Methods: Natural acquisition of antibody and T cell immunity to Salmonella was investigated in healthy and Salmonella infected Malawian children. Acquisition of typhoid vaccine induced T cell immunity in healthy adults from the United Kingdom (UK) was investigated to model natural immunizing events occurring within the gut associated lymphoid tissues (GALTs) following Salmonella infection. Acquisition of immunity was examined using immunological tools including the intra-cellular cytokine staining assay (ICS), serum bactericidal activity (SBA) assay, ELISA and ELISpot. Exposure to Salmonella was examined using microbiological tools including standard culture and real-time PCR. Principal findings: CD4+ T cells and IgG antibodies to Salmonella develops sequentially in under-five children. Acquisition of Salmonella-specific CD4+ T cells and antibodies coincides with the decline in S. Typhimurium bacteraemia cases in older children. As much as 47% of Malawian children (aged 6-18 months) are exposed to Salmonella at least once within the gastrointestinal tract (GIT). Natural Salmonella exposure within the GIT is associated with development of potentially protective SBA in children. Invasive Salmonella infection elicits an increase in generation of Salmonella-specific CD4+T cells, IgG and IgA antibody secreting cells (ASC). Oral Ty21a vaccination (model of natural Salmonella infection) did not elicit an increase in generation of both CD4+Cytokine+ and CD8+Cytokine+ T cells in the peripheral blood and gut mucosa compartments at day 11, and day 18 post vaccination. Conclusion: Young children (
When is retrieval better than generation?
Creators: name: Gangadhar, Govind Krishnan
Publisher: name: No Publisher Supplied
Year: 2023

description: A surprising recent finding is that generation-based models (GBMs), i.e., large language models that generate rather than retrieve contexts, match or even outperform retrieval-based models (RBMs) on zero-shot knowledge-intensive tasks. This is surprising because even if the model can in principle encode and recall the contexts seen during pretraining, an explicit retrieval mechanism that accesses pristince facts in a knowledge base seems fundamentally important. In this work, we first hypothesize that RBMs are in fact more performant than GBMs if the retrieved contexts are sufficiently high quality. We consider a simple unsupervised reranking and obtain a dramatic improvement over naive retrieval, significantly outperforming GBMs on fact checking. However, we find that RBMs still lag behind GBMs on question answering (QA) even with this improvement. Our results highlight the pros and cons of context retrieval and generation and suggest possible reasons why one works better than the other depending on the task.
title: Development of ANEW 3D euler-lagrange model for the prediction of scour around offshore structures
Creators: name: Li, Y
name: Kelly, DM
name: Li, M
name: Harris, JM
Publisher: name: University of Liverpool Repository
Year: 2016

description: Numerical modelling of local scour around offshore structures has recently grown in importance with the increased deployment of offshore wind turbines. Compared to single-phase models, the multiphase approach is gaining in popularity due to its capability to better interpret the flow-sediment interaction, sediment-sediment interaction and flow-structure interaction. In Euler-Euler multiphase models, both the fluid and solid phases are treated as continuum, therefore, the fluid-particle interactions cannot be resolved naturally. Moreover, Eulerian models often struggle to model complex deformation and interface fragmentation. In contrast, in pure Lagrangian models, the inherent discrete particle property of sediment can be better represented; however, Lagrangian models are particularly demanding on computational resource. Thus, Euler-Lagrange models provide an attractive alternative retaining the advantage of simulating the solid phase naturally while being computationally efficient. In this paper, a three-dimensional Euler-Lagrange scour model based on the open source CFD software Open FOAM®will be presented and validated. The fluid phase is resolved by solving modified Navier-Stokes equations, which take into consideration the influence of the solid phase, i.e., the particles. The sold phase is solved using multi-phase particle-in-cell (MP-PIC) approach. The particles follow Newton's Law of Motion. The hydrodynamic performance of the model is validated against experimental measurements. The impact of steady current on scour development around cylinders is also investigated.
Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
Creators: name: Zanger, U. M.
name: Smith, P. C.
name: Klein, K.
name: Villeneuve, L.
name: Fallon, J. K.
name: Caron, P.
name: Guillemette, C.
name: Margaillan, G.
name: Rouleau, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study determined the expression of hepatic UGTs by targeted proteomics in 48 liver samples and by measuring the glucuronidation activity using probe substrates. It demonstrates the sensitivity and accuracy of nano-ultra-performance liquid chromatography with tandem mass spectrometry to establish the complex expression profiles of 14 hepatic UGTs in a single analysis. UGT2B7 is the most abundant UGT in our collection of livers, expressed at 69 pmol/mg microsomal proteins, whereas UGT1A1, UGT1A4, UGT2B4, and UGT2B15 are similarly abundant, averaging 30–34 pmol/mg proteins. The average relative abundance of these five UGTs represents 81% of the measured hepatic UGTs. Our data further highlight the strong relationships in the expression of several UGTs. Most notably, UGT1A4 correlates with most measured UGTs, and the expression levels of UGT2B4/UGT2B7 displayed the strongest correlation. However, significant interindividual variability is observed for all UGTs, both at the level of enzyme concentrations and activity (coefficient of variation: 45%–184%). The reliability of targeted proteomics quantification is supported by the high correlation between UGT concentration and activity. Collectively, these findings expand our understanding of hepatic UGT profiles by establishing absolute hepatic concentrations of 14 UGTs and further suggest coregulated expression between most abundant hepatic UGTs. Data support the value of multiplexed targeted quantitative proteomics to accurately assess specific UGT concentrations in liver samples and hepatic glucuronidation potential.
title: Integrated approach to developing agile strategies
Creators: name: Hetherington, Mark
Publisher: name: University of Liverpool Repository
Year: 2023

description: Thep rojectl ooksa t Agility andA gile manufacturingin particular,w ith a focuso n the SME type businessT. he initial focus is on the developmenot f the ASF (Agile Strategic Framework) to make the selection of tools and techniques for manufacturing environments automated and systematised. This is to give consistency of approach, repeatability and to develop the system automation potential. This work will produce a test type model of how the business environment audit tool can be automated to produce results quickly and easily with less human time and intervention. One part of the ASF which needs particular development is the process of examining a company strategy from an agility type perspective. The project fills this niche by looking at how agility fits with traditional schools of strategy, how it relates to definitions of agility from content analysis and pulls these together. Using grounded theory and qualitative methods to examine the meanings, usage and context of Agility an examination of how this may relate to TRIZ type systems using agility paradigms is undcrtaken. This particular study relates to agility in a large context including software, construction and business processes as well as manufacturing definitions. A working model with Case Study examples is suggested as a point for further development.
title: Automatic feature detection and interpretation in borehole data
Creators: name: Al-Sit, Waleed
Publisher: name: University of Liverpool Repository
Year: 2015

description: Detailed characterisation of the structure of subsurface fractures is greatly facilitated by digital borehole logging instruments, however, the interpretation of which is typically time-consuming and labour-intensive. Despite recent advances towards autonomy and automation, the final interpretation remains heavily dependent on the skill, experience, alertness and consistency of a human operator. Existing computational tools fail to detect layers between rocks that do not exhibit distinct fracture boundaries, and often struggle characterising cross-cutting layers and partial fractures. This research proposes a novel approach to the characterisation of planar rock discontinuities from digital images of borehole logs by using visual texture segmentation and pattern recognition techniques with an iterative adaptation of the Hough transform. This approach has successfully detected non-distinct, partial, distorted and steep fractures and layers in a fully automated fashion and at a relatively low computational cost. Borehole geometry or breakouts (e.g.borehole wall elongation or compression) and imaging tool decentralisation problem affect fracture characterisation and the quality of extracted geological parameters. This research presents a novel approach to the characterisation of distorted fracture in deformed borehole geometry by using least square ellipse fitting and modified Hough transform. This approach approach has successfully detected distorted fractures in deformed borehole geometry using simulated data. To increase the fracture detection accuracy, this research uses multi-sensor data combination by combining extracted edges from different borehole data. This approach has successfully increased true positive detection rate. Performance of the developed algorithms and the results of their application have been promising in terms of speed, accuracy and consistency when compared to manual interpretation by an expert operator. It is highly anticipated that the findings of this research will increase significantly the reliance on automatic interpretation.
Entanglement entropy and Schmidt number as measures of delocalization of $α$ clusters in one-dimensional nuclear systems
Creators: name: Kanada-En'yo, Yoshiko
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We calculated the von Neumann entanglement entropy and the Schmidt number of one dimentional (1D) cluster states and showed that these are useful measures to estimate entanglement caused by delocalization of clusters. We analyze system size dependence of these entanglement measures in the linear-chain $nα$ states given by Tohsaki-Horiuchi-Schuck-Röpke wave functions for 1D cluster gas states. We show that the Schmidt number is an almost equivalent measures to the von Neumann entanglement entropy when the delocalization of clusters occurs in the entire system but it shows different behaviors in a partially delocalized state containing localized clusters and delocalized ones. It means that the Rényi-2 entanglement entropy, which relates to the Schmidt number, is found to be almost equivalent to the von Neumann entanglement entropy for the full delocalized cluster system but it is less sensitive to the partially delocalized cluster system than the von Neumann entanglement entropy. We also propose a new entanglement measure which has a generalized form of the Schmidt number. Sensitivity of these measures of entanglement to the delocalization of clusters in low-density regions was discussed.
description: 15 pages, 10 figures
title: An evaluation of bioclimatic high rise office buildings in a tropical climate : energy consumption and users' satisfaction in selected office buildings in Malaysia
Creators: name: Hakim Ismail, Lokman
Publisher: name: University of Liverpool Repository
Year: 2023

description: This research has been carried out with the aim to investigate how high rise office building design in tropical climate can contribute in reducing energy consumption while maintaining comfort. The main objective of this study is to compare the performance of a sample of bioclimatic high rise office blocks with that of conventional ones when situated in a tropical climate such as that in Malaysia. The research firstly reviewed all the characteristics of bioclimatic buildings in the Malaysian Peninsula particularly the traditional Malay house and the transformation through time. Secondly, the research studied some design planning and architecture of several high-rise office buildings principally the bioclimatic approaches. Thirdly, the claimed benefits of bioclimatic design approach for high rise office buildings were examined in the results of previously conducted research projects, dealing with energy consumption and design approaches which compares the bioclimatic and conventional high rise. The performance was measured according to a combination of technical and social criteria: direct observation on various architectural aspects, environmental measurement and users' perception of comfort and satisfaction with their working environment via questionnaires. The energy consumptions were compared based on the electricity bills recorded for at least a year period. The local building energy index is used as the benchmark to check whether there were real energy savings in the bioclimatic high rise office blocks or otherwise. The major finding of this work is that the occupants in bioclimatic high rise office buildings have a higher level of satisfaction with their working environment than those in conventional office blocks. There is evidence that bioclimatic high rise office buildings are energy efficient as the most recent bioclimatic high rise office building (Menara UMNO), has a lower energy index than the ASEAN standard and within the latest Malaysian Standard related to energy efficiency. In the past, high rise buildings have been perceived as inefficient users of energy, with the new bioclimatic design concept and technologies, there is no doubt that high rise office buildings in the future would be much better in design that provide better environment to the users and consume less energy.
[6 Ansichten aus Italien]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: 313. Portovenere
description: Ponte di Legno
description: 3283. Protofino [...]
description: 16130. Lago di Garda; Punta San Vigilio
description: 3897. Reggio d'Emilia la. La Cattedrale
description: 8889. lago di Trasimeno (Passigliano). Piccolo Porto con Vista delle Isole Maggiore e Minore
description: Es handelt sich bei den Aufnahmen um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation 2024 TIFF
Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors
Creators: name: Swaan, P. W.
name: Brouwer, K. L. R.
name: Urban, T. J.
name: Welch, M. A.
name: Kock, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Drug-induced liver injury (DILI) is an important cause of drug toxicity. Inhibition of multidrug resistance protein 4 (MRP4), in addition to bile salt export pump (BSEP), might be a risk factor for the development of cholestatic DILI. Recently, we demonstrated that inhibition of MRP4, in addition to BSEP, may be a risk factor for the development of cholestatic DILI. Here, we aimed to develop computational models to delineate molecular features underlying MRP4 and BSEP inhibition. Models were developed using 257 BSEP and 86 MRP4 inhibitors and noninhibitors in the training set. Models were externally validated and used to predict the affinity of compounds toward BSEP and MRP4 in the DrugBank database. Compounds with a score above the median fingerprint threshold were considered to have significant inhibitory effects on MRP4 and BSEP. Common feature pharmacophore models were developed for MRP4 and BSEP with LigandScout software using a training set of nine well characterized MRP4 inhibitors and nine potent BSEP inhibitors. Bayesian models for BSEP and MRP4 inhibition/noninhibition were developed with cross-validated receiver operator curve values greater than 0.8 for the test sets, indicating robust models with acceptable false positive and false negative prediction rates. Both MRP4 and BSEP inhibitor pharmacophore models were characterized by hydrophobic and hydrogen-bond acceptor features, albeit in distinct spatial arrangements. Similar molecular features between MRP4 and BSEP inhibitors may partially explain why various drugs have affinity for both transporters. The Bayesian (BSEP, MRP4) and pharmacophore (MRP4, BSEP) models demonstrated significant classification accuracy and predictability.
Investigating interrater agreement in binary time series
Creators: name: Bodner Nadja
Publisher: name: Zenodo
Year: 2023
Subjects: Cohen's Kappa, interrater agreement, binary time series, error rate permutation-based significance testing, shiny app

description: In observational studies, intensive longitudinal data are often collected by coding the presence/absence of behavior across time. Having a sufficiently high interrater agreement is then quintessential. Although a host of alternatives exist, Cohen’s Kappa has been most popular ever since the measure has been introduced. In many cases, the obtained interrater agreement values are interpreted using the benchmarks provided by, for example, Landis and Koch. This is, however, problematic because of two reasons: First, the value of Cohen’s Kappa (and many other interrater agreement measures) is impacted by the prevalence of the coded behavior. Second, these measures ignore the serial dependence that typically characterizes time series data. In this study, we aim to develop a test that allows interpreting a Kappa value in a given situation. Therefore, we will make use of the error rate committed by the coders during that coding process. For good coding reliability, we will, of course, aim for data where only a few mistakes have been committed. We will introduce a simulation paradigm that accounts for the serial dependence and relative frequency of the true data but also implements several mistakes corresponding with the benchmarks of Landis & Koch. On this data, we calculate Cohen’s Kappa. This sampling distribution which contains a fixed number of mistakes is used for a one-sided significance test that investigates whether the values calculated on the rater-reported data are significantly higher than could be expected given the implemented error rate (and therefore are of acceptable quality).
description: The data and R code that support the findings of this study are available on https://gitlab.kuleuven.be/ppw-okpiv/researchers/u0090403/mirror. The shiny app can be accessed at https://gitlab.kuleuven.be/ppw-okpiv/researchers/u0090403/irrtest . A more advanced version, ia available at https://gitlab.kuleuven.be/ppw-okpiv/researchers/u0090403/shinymirror .
[4 Ansichten der Etruskerstätte um Vejo]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1899

description: Veduten der Landschaft um Vejo
description: 4555. Rovine di Vejo
description: 4556. Colombario di Vejo
description: 4558. Tomba Campana a Vejo
description: 4557. Ponte Sodo Vejo
description: Unbekannte/r Fotograf/in
description: Abzüge auf einen Karton motiert
description: Karton auf der Rückseite beschriftet
description: Digitalisierung=Digitization=Numérisation 2024 TIFF
title: The electrochemistry of supported metal multilayers: In-situ surface x-ray scattering studies
Creators: name: Sisson, Naomi Katie
Publisher: name: University of Liverpool Repository
Year: 2015

description: A combination of in-situ surface x-ray scattering (SXS) and cyclic voltammetry (CV) measurements have been performed to develop an increased understanding of supported metal multilayers on single crystal metal substrates. The formation of ordered metal structures and metal oxides are investigated together with the effect of the surface modification on processes such as OH adsorption and hydrogen evolution. A detailed in-situ study of the structure and behaviour of underpotentially deposited (UPD) monolayer and bilayer of Ag on the Au(111) surface is given both before and after transfer of the electrode to alkaline electrolyte. Analysis of the SXS data shows that while the bilayer is stable upon transfer, the Ag monolayer reorders to a partial bilayer. Sulphate anions in the UPD electrolyte stabilise the monolayer as it is formed, however upon transfer to the alkaline electrolyte these are replaced by more specifically adsorbed OH- ions causing the Ag to restructure to the more stable partial bilayer. The Ag modified electrodes show potential response for OH- adsorption similar to that of Ag single crystals. Detailed modelling of the SXS data at the positive potential limit in alkaline electrolyte shows evidence of an ordered OH- layer in the electrochemical double layer. Sub-surface OH indicated in the CV is confirmed in the SXS by a roughening of the topmost Ag layer. The atomic structure and properties of Co thin films electrodeposited onto Au(111) electrode is investigated using STM and SXS. Measurements confirm that the Co initially grows on the surface as a bilayer. Detailed characterisation of the thin film structure was obtained by analysis of the specular CTR. Results show a small outward expansion in the Co film which may be caused by the presence of adsorbed hydrogen on the Co surface. Changes induced by the presence of CO were investigated and it was found that CO has a dramatic effect on the magnetisation but only cause very small changes in the atomic structure of the Co film. The measurements indicate the changes in magnetic behaviour are driven by subtle changes in the electrolyte double layer region adjacent to the Co surface. Thin films of Co were deposited on a Au(111) electrode prior to transfer of the electrode to alkaline electrolyte. Ex-situ AFM imaging revealed that the Co is present on the Au(111) surface in the form of large islands which cover approximately 2.2% of the surface and are located at step edges. Their presence gives rise to a modified reconstruction of the topmost Au layer which was also investigated. Resonant SXS measurements revealed that Co is present both in its metallic state and charged state, most likely in the form Co(OH)2. The Co-modified Au(111) surface shifts the potential for hydrogen evolution positively by ~ 0.1 V compared with that of clean gold.
Piona caligifera Koenike 1898
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Pionidae
Piona
Piona caligifera

description: Piona caligifera (Koenike, 1898)
Records from the study area: Maharashtra—“ Piona indica “ Cook (1967); “ P. indica “ Prasad (1974).
Remark: Lundblad (1969) synonymized Piona indica Cook with P. caligifera (Koenike, 1898).
Habitat: Ponds and open wells.
Distribution: Madagascar, India, Sri Lanka.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 30, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
On singular values distribution of a large auto-covariance matrix in the ultra-dimensional regime
Creators: name: Wang, Qinwen
name: Yao, Jianfeng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Let $(\varepsilon_{t})_{t>0}$ be a sequence of independent real random vectors of $p$-dimension and let $X_T=\sum_{t=s+1}^{s+T}\varepsilon_t\varepsilon^T_{t-s}/T$ be the lag-$s$ ($s$ is a fixed positive integer) auto-covariance matrix of $\varepsilon_t$. This paper investigates the limiting behavior of the singular values of $X_T$ under the so-called {\em ultra-dimensional regime} where $p\to\infty$ and $T\to\infty$ in a related way such that $p/T\to 0$. First, we show that the singular value distribution of $X_T$ after a suitable normalization converges to a nonrandom limit $G$ (quarter law) under the forth-moment condition. Second, we establish the convergence of its largest singular value to the right edge of $G$. Both results are derived using the moment method.
description: 32 pages, 2 figures
[2 Ansichten von Ninfa]
Creators: name: Studio Fotografico Fratelli D'Alessandri
Publisher: name: F.lli d'Alessandri
Year: 1899

description: Unbekannte/r Fotogrraf/in
description: Abzüge auf Karton montiert
description: Datierung gemäss handschriftlicher Notiz auf der Rückseite des Kartons
description: Digitalisierung=Digitization=Numérisation 2024 TIFF
title: Civil Service reform in Ireland 1922 to 2012
Creators: name: O'Toole, John
Publisher: name: University of Liverpool Repository
Year: 2015

description: This thesis examines civil service reform in Ireland from independence to 2012. Following independence, inexperienced and over-burdened Ministers gave the civil service, which was dominated by the Department of Finance, considerable autonomy. This creation of an impartial civil service remains one of the great achievements of the Irish State. The thesis finds that progress on administrative reform has been uneven and limited due to a combination of lack of political will and obstacles within the administration. Efforts to reform the civil service began with the 1935 Brennan Commission, and continued with the Devlin Report, 1969. This work examines the challenges faced by Taoiseach Garret FitzGerald and by John Boland, first Minister for the Public Service, in reforming the civil service. Later initiatives to reform the civil service are also analysed. The thesis finds that both political will and administrative support are required for administrative reform. Ireland’s economic collapse in 2008 transformed the approach to administrative reform through the Troika of the European Commission, International Monetary Fund and European Central Bank. Administrative reform was a key element of the strategic response to economic crisis for the government which came to office in 2011. Reforms were therefore driven by external financiers who required that Ireland modernise its public administration. The establishment of the Department of Public Expenditure and Reform in 2011 highlighted this. Uniquely, this new department combined both expenditure and reform elements. Earlier lessons in relation to poor implementation of reform were learned, with a strong focus on implementation and delivery. The Public Service Reform Plan of November 2011 set out 70 recommendations and 200 actions across five areas. This plan emphasised ownership within departments, with dedicated reform teams working under a Cabinet committee. The plan also highlighted the importance of implementation with deadlines, dates and ownership. The Irish civil service made good progress in recent years in reducing costs, improving productivity, the online delivery of services, developing shared services and putting in place administrative reforms. By drawing on the lessons learned since independence, particularly from the most recent economic crisis, governments and policy-makers may be better prepared to implement future administrative reforms.
title: Zirconium doped zinc oxide thin films deposited by atomic layer deposition
Creators: name: Herodotou, Stephania
Publisher: name: University of Liverpool Repository
Year: 2015

description: Doped zinc oxide is of interest as a transparent conductive oxide (TCO), due to the abundance of its major constituents, its low resistivity, high transparency and wide bandgap. The current work focuses on the properties required for TCO applications including resistivity of ≤10-3 Ω•cm, carrier density of ≥1020 cm-3, and transparency >80% in the visible light. Zirconium (Zr4+) was chosen as the dopant in the current work due to its abundance, comparable ionic size to Zn and because it can act as a double donor providing up to two extra free electrons per ion when substituted for Zn2+. The doping process can be controlled using atomic layer deposition (ALD), with the doped films resulting in an increased conductivity. The films in the current work resulted in a minimum resistivity of 1.44×10-3 Ω•cm and maximum carrier density of 3.81×1020 cm-3 for films
Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family
Creators: name: Nguyen, M. T.
name: Fay, M. J.
name: Grant, D. J.
name: Bodnar, W. M.
name: Koller, B. H.
name: Dye, R.
name: Snouwaert, J. N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: UDP-Glucuronosyltransferases (UGTs) conjugate a glucuronyl group from glucuronic acid to a wide range of lipophilic substrates to form a hydrophilic glucuronide conjugate. The glucuronide generally has decreased bioactivity and increased water solubility to facilitate excretion. Glucuronidation represents an important detoxification pathway for both endogenous waste products and xenobiotics, including drugs and harmful industrial chemicals. Two clinically significant families of UGT enzymes are present in mammals: UGT1s and UGT2s. Although the two families are distinct in gene structure, studies using recombinant enzymes have shown considerable overlap in their ability to glucuronidate many substrates, often obscuring the relative importance of the two families in the clearance of particular substrates in vivo. To address this limitation, we have generated a mouse line, termed ΔUgt2, in which the entire Ugt2 gene family, extending over 609 kilobase pairs, is excised. This mouse line provides a means to determine the contributions of the two UGT families in vivo. We demonstrate the utility of these animals by defining for the first time the in vivo contributions of the UGT1 and UGT2 families to glucuronidation of the environmental estrogenic agent bisphenol A (BPA). The highest activity toward this chemical is reported for human and rodent UGT2 enzymes. Surprisingly, our studies using the ΔUgt2 mice demonstrate that, while both UGT1 and UGT2 isoforms can conjugate BPA, clearance is largely dependent on UGT1s.
title: Curved axes and trajectories for multidimensional scaling, with applications to sensory and consumer data
Creators: name: John Bennett, Stephen
Publisher: name: University of Liverpool Repository
Year: 2023

description: The analysis of sensory and consumer-derived data involves the use of many different statistical techniques. The vast majority of these are multivariate in for example, multidimensional scaling (MDS) and biplots. However, univariate techniques such as repeated measures analysis of variance and the Bradley-Terry model for paired comparison data are also common. This thesis introduces enhancements to MDS based on the use of curved axes and trajectories.
6572. Veduta della Necropoli di Norchia presso Viterbo
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1899

description: Vedute der Nekropole von Norchia
description: Unbekannte/r Fotograf/in
description: Datierung gemäss handschriftlicher Notiz auf der Rückseite der Unterlage
description: Abzug auf eine Unterlage montiert
description: Digitalisierung=Digitization=Numérisation 2024 TIFF
title: The role of heparan sulphate in the development of mouse embryoid bodies
Creators: name: Hazeldine, Poppy
Publisher: name: University of Liverpool Repository
Year: 2015

description: The development of in vitro Embryoid Body (EB) formation facilitates the investigation of many aspects of cell differentiation occurring during early mammalian development. The function of various factors, such as fibroblast growth factors (FGFs) and their corresponding pathways within embryogenesis, has been widely studied. It is well documented that the polysaccharide Heparan Sulphate (HS) is essential for normal development within mouse embryonic stem cells (mESC); this is thought to be due its role as a co-factor in FGF signalling. Despite acting as a successful model for periimplantation, HS-deficient EBs have yet to be fully characterised and it is undetermined if they develop in a similar way to EBs generated from wild-type (WT) cells. The aim of this study was to investigate the role of HS in the development of mouse EBs at Day 4 derived from WT and EXT1-/- mESCs. The differentiation of Primitive Endoderm (PrE) and the subsequent synthesis of a basement membrane were primarily investigated using immunofluorescence and quantitative Polymerase Chain Reaction (qPCR). The expression of mesoderm, ectoderm and pluripotency markers were also analysed using these techniques.
title: The effect of PETTLEP-based imagery interventions on motor performance.
Creators: name: Joy Wright, Caroline
Publisher: name: University of Liverpool Repository
Year: 2023

description: This series of studies investigated the effectiveness of the PETTLEP model across a variety of tasks. In the first two studies, interventions arising from this model were compared to traditional imagery interventions and physical practice. Study 1 compared a six-week intervention of PETTLEP imagery, traditional imagery, physical practice and an intervention combining PETTLEP imagery and physical practice for strength training. Analysis indicated that the PETTLEP combination group, PETTLEP imagery group and physical practice group improved significantly from pre-test to post-test, whereas the traditional imagery group and control group did not. Study 2 compared the effects of PETTLEP imagery, traditional imagery and physical practice interventions on performance of a computer-game. Results showed that the PETTLEP imagery group and physical practice group improved from pre-test to posttest, whereas the traditional imagery group and control group did not. These two studies indicate that PETTLEP imagery is more beneficial to performance than traditional imagery, and as effective as physical practice. Study 3 and 4 compared differing amounts of PETTLEP imagery on a netball task (over a four week period) and a strength task (over a twenty-two week period). Results indicated that the larger the amount of imagery completed, the larger the apparent performance effect. However, there were exceptions and this should be investigated further with differing doses of imagery, focussing on frequency and volume of imagery. This series of studies has shown PETTLEP imagery to be effective in improving performance on a variety of tasks, including cognitive, motor and strength tasks. It has also shown PETTLEP to be effective over a number of timescales, ranging from forty five minutes to twenty two weeks. In the first two studies it was shown to be as effective as physical practice. Therefore, sport psychologists and coaches should follow the guidelines set out in the PETTLEP model to individualise their imagery interventions and increase their functional equivalence. Additionally, the amount of imagery completed and its ratio to physical practice should also be considered in order to have the greatest possible effect on sports performance. Supplied by The British Library - 'The world's knowledge'
Aphaenogaster (Ischnomyrmex) longipes Sm.
Creators: name: Emery, Carlo
Publisher: name: Zenodo
Year: 1887
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Aphaenogaster
Aphaenogaster longipes

description: 22. Aphaenogaster (Ischnomyrmex) longipes Sm. Sumatra, Siboga Questi esemplari corrispondono perfettamente alle descrizioni di Smith e di Mayr e si allontanano molto dalla forma che ho descritta in questo Catalogo col nome di var. laeuior: quest’ultima dovrà essere considerata come specie a sè. L’A è distinta dalle forme affini del gruppo Ischnomyrmex (laevior Em., Beccarii Em., Swammerdami For.) per l’assenza di una carena al margine esterno della fossa antennale, per la impressione profonda che separa lo scutello dal resto del meso-noto (fig. 2), per la forma del metanoto le cui spine sono sottili e ritte (Smith scrive: " short, acute, upright spines ") e per la forma del primo segmento del peduncolo, che è appena debolmente elevato nella sua parte posteriore. Tutto il corpo, con i piedi è sparso di setole sottili e pallide, mentre nelle altre tre forme, i peli ritti sono grossi, ottusi e scuri. Le figure 2-5 faranno meglio risaltare le differenze (1). (1) Il quadro analitico seguente verrà ad agevolare la determinazione delle specie finora descritte di Ischnomyrmex. Gli I. exasperatus e rhaphidiiceps mi sono noti soltanto dalle descrizioni del Mayr. .A.. Articolo 9, del flagello notevolmente più grande dell’ 8.°, formante con i seguenti una clava di 3 articoli.. • exasperatus Mayr.
description: Published as part of Emery, Carlo, 1887, Catalogo delle formiche esistenti nelle collezioni del Museo Civico di Genova. Parte terza (supplemento). Formiche raccolte dal sig. Elio Modigliani in Sumatra e nell'isola Nias., pp. 528-534 in Annali del Museo Civico di Storia Naturale Giacomo Doria (Genova) (2) 5 (25) on page 531, DOI: 10.5281/zenodo.11534
Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity
Creators: name: Brouwer, Kim L.R.
name: Swift*, Brandon
name: Pfeifer*, Nathan D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Sandwich-cultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to study hepatobiliary drug transport, species differences in drug transport, transport protein regulation, drug-drug interactions, and hepatotoxicity. This review provides an up-to-date summary of the SCH model, including a brief history of, and introduction to, the use of SCH, as well as methodology to evaluate hepatobiliary drug disposition. A summary of the literature that has utilized this model to examine the interplay between drug metabolizing enzymes and transport proteins, drug-drug interactions at the transport level, and hepatotoxicity as a result of altered hepatic transport also is provided.
The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families
Creators: name: Redinbo, Matthew R.
name: Miley, Michael J.
name: Radominska-Pandya, Anna
name: Bratton, Stacie M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Human UDP-glucuronosyltransferases (EC 2.4.1.17) (UGTs) are major phase II metabolism enzymes that detoxify a multitude of endo- and xenobiotics through the covalent addition of a glucuronic acid moiety. UGTs are promiscuous enzymes that regulate the levels of numerous important endobiotics in a range of tissues, and inactivate most therapeutic compounds in concert with phase I enzymes. In spite of the importance of these enzymes, we have only a limited understanding of the molecular mechanisms governing their substrate specificity and catalytic activity. Until recently, no three-dimensional structural information was available for any mammalian UGT. The 1.8-Å resolution apo crystal structure of the UDP-glucuronic acid binding domain of human UGT2B7 (2B7CT) is the only structure of a mammalian UGT target determined to date. In this review, we summarize what has been learned about human UGT function from the analysis of this and other related glycosyltransferase (GT) crystal structures.
[34 Ansichten von Neapel]
Creators: name: Sommer, Giorgio
Publisher: name: [s.n.]
Year: 1885

description: 321. Napoli. Veduta della Fontana Medina
description: A. 287. Fontana della Villa Nazionale di Napoli
description: 5098a. Napoli. Museo Nazionale. Antonio, statua di buono stile greco (Farnese)
description: 5274a. Napoli. Museo Nazionale. Platone, busto in bronzo (Ercolano, 1759)
description: Napoli. Grotta di osilipo e Tomba di Virgilio No. 89
description: No.90 Napoli. Intero della Grotta di Pozzuoli
description: N. 78. Napoli. Eruzione del Vesuvio
description: 5110a. Napoli. Panorama presto dalla Tomba di Virgilio
description: No. 1112 Napoli da[...]
description: No. 18. Strada PIliero Carmine e Porto [...]
description: 47. Napoli. Riviera di Chiaja
description: 1144 Napoli Villa Nazionale
description: 1121. Castello del'Ovo Napoli
description: 1107. Napoli. Villa del Popolo
description: 1105 Napoli S. Lucia
description: 5472a. Napoli. Strada Roma già Toledo (veduta animata)
description: 5471. Napoli. Strada Santa Lucia
description: 1124. Napoli Museo Nazionale
description: No. 67. Arco di Alfonso di Aragona. Napoli
description: No. 272 Napoli. Veduta della Porta Capuana
description: 1115. Napoli. Porta Capuana
description: No. 79. Rovine del palazzo di D. Anna a Posilipo. Napoli
description: [Neapel]
description: N. 26 Napoli - Palazzp Reale
description: 5196. Napoli. Chiostro della Certosa di S. Martino, con colonne doriche in marmo
description: No. 9. Napoli. INterno della Certusa di S. Martino
description: No. A. 275. Napoli. Chiesa del Carmine
description: 11801 Napoli Interno del Duomo
description: No. 1128 Atrio di S. Martino Napoli
description: No. 7 Napoli. Interno del Chiostro di S. Martino
description: No. 1110 [...] di S. Martino. Napoli
description: No. 9. Napoli Interno della Certusa di S. Martino
description: 5200. Napoli. Cancello del Giardino reale: i cavalli sono opera del bar. Clodt, e dono dell'imp. Niccolò di Russia
description: Sommer ; [und weitere]
description: Abzüge auf Karton montiert und auf der Rückseite beschriftet
description: Nicht alle Fotografien können einem Urheber zugeschrieben werden
description: Digitalisierung=Digitization=Numérisation 2024 TIFF