Structural-Functional Transition in Glaucoma Assessment
Creators: name: Huazhu Fu
name: Yanwu Xu
name: Xiulan Zhang
name: Li, Fei
name: Orlando, José Ignacio
name: Bogunovic, Hrvoje
Publisher: name: Zenodo
Year: 2023
Subjects: Glaucoma assessment
macular OCT
visual field test
classification
regression
MICCAI Challenges

description: This challenge is to predict the result of the visual field (VF) test using volume optical coherence tomography (OCT) scans centered at the fovea. OCT is now the most widely used imaging modality used in ophthalmology tests, which provides objective cross-sectional information of the structures in the fundus, facilitating the physician's observation of structural thickness changes, and is an important basis in the diagnosis of glaucoma [1]. There is now much evidence to support the role of OCT imaging in the detection of glaucoma [2-5]. A VF test is a reference standard examination to assess visual function. It is a subjective examination that requires the subject to remain calm and focused and to cooperate with the physician. The monocular visual field examination takes approximately 15 minutes. It is the clinical standard to decide whether there is glaucomatous optic nerve damage [6]. In contrast, a monocular volume OCT scan takes only about 3 seconds. Furthermore, there is a moderate to good correlation between retinal layer thickness and central VF sensitivities or other markers of optic nerve function [7]. Therefore, this challenge focuses on how to predict functional VF information using objective and easy-to-acquire structural OCT images. Three tasks are proposed for this challenge: 1) mean deviation (MD) value prediction; 2) sensitivity map prediction; 3) pattern deviation probability map prediction. Our challenge will provide 400 volume OCT data and corresponding MD value, sensitivity map, and pattern deviation probability map labels of the VF test report. Of these, 200 macular OCT data and corresponding labels will be released to the teams for model training in the preliminary round. 100 macular OCT data will also be released in the preliminary round, and the evaluation platform will be opened for the teams to validate and tune their models based on the preliminary leaderboard. The remaining 100 macular OCT data will be released in the final round for the evaluation of the model. From the technical point of view, this challenge is concerned with computer vision studies, among which, tasks 1 and 2 involve metric regression problems, and task 3 involves a classification<br> problem. These studies are essential in computer-aided clinical diagnosis. From a biomedical perspective, this challenge is to seek the mapping relationship between the fundus structure and visual function, which is important for understanding the underlying causes of visual defects. [1] Schuman J S, Hee M R, Arya A V, et al. Optical coherence tomography: a new tool for glaucoma diagnosis[J]. Current opinion in ophthalmology, 1995, 6(2): 89-95.<br> [2] Chen M J, Chang Y F, Kuo Y S, et al. Macular ganglion cell-inner plexiform vs retinal nerve fiber layer measurement to detect early glaucoma with superior or inferior hemifield defects[J]. Journal of the Chinese Medical Association, 2019, 82(4): 335-339.<br> [3] Kim K E, Park K H. Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma[J]. British Journal of Ophthalmology, 2018, 102(6): 718-724<br> [4] Wu Z, Weng D S D, Thenappan A, et al. Evaluation of a region-of-interest approach for detecting progressive glaucomatous macular damage on optical coherence tomography[J]. Translational Vision Science &amp; Technology, 2018, 7(2): 14-14.<br> [5] Asrani S, Rosdahl J A, Allingham R R. Novel software strategy for glaucoma diagnosis: asymmetry analysis of retinal thickness[J]. Archives of ophthalmology, 2011, 129(9): 1205-1211.<br> [6] Garway-Heath D F, Poinoosawmy D, Fitzke F W, et al. Mapping the visual field to the optic disc in normal tension glaucoma eyes[J]. Ophthalmology, 2000, 107(10): 1809-1815.<br> [7] Mohammadzadeh V, Fatehi N, Yarmohammadi A, et al. Macular imaging with optical coherence tomography in glaucoma[J]. Survey of ophthalmology, 2020, 65(6): 597-638.