cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Improved fluorescent phytochromes for in situ imaging
Creators: name: Nagano, Soshichiro
name: Sadeghi, Maryam
name: Balke, Jens
name: Fleck, Moritz
name: Heckmann, Nina
name: Psakis, Georgios
name: Alexiev, Ulrike
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Biochemistry
subject: Biological fluorescence
subject: Biophysics
subject: Molecular biophysics
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Modern biology investigations on phytochromes as near-infrared fluorescent pigments pave the way for the development of new biosensors, as well as for optogenetics and in vivo imaging tools. Recently, near-infrared fluorescent proteins (NIR-FPs) engineered from biliverdin-binding bacteriophytochromes and cyanobacteriochromes, and from phycocyanobilin-binding cyanobacterial phytochromes have become promising probes for fluorescence microscopy and in vivo imaging. However, current NIR-FPs typically suffer from low fluorescence quantum yields and short fluorescence lifetimes. Here, we applied the rational approach of combining mutations known to enhance fluorescence in the cyanobacterial phytochrome Cph1 to derive a series of highly fluorescent variants with fluorescence quantum yield exceeding 15%. These variants were characterised by biochemical and spectroscopic methods, including time-resolved fluorescence spectroscopy. We show that these new NIR-FPs exhibit high fluorescence quantum yields and long fluorescence lifetimes, contributing to their bright fluorescence, and provide fluorescence lifetime imaging measurements in E.coli cells.
Failure pattern and salvage treatment after radical treatment of head and neck cancer
Creators: name: Pagh, Anja
name: Grau, Cai
name: Overgaard, Jens
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Purpose The aim of the study was to test the hypothesis that head and neck cancer (HNC) patients benefit from specialized follow-up (FU), as this strategy ensures timely detection of relapses for successful salvage treatment. This was done by evaluation of the pattern of failure, the temporal distribution of recurrences, and the outcome of salvage treatment in a contemporary cohort of HNC patients. Methods The study evaluated a cohort of 2062 consecutive patients treated with curative intent at Aarhus University Hospital from 1 January 2000 to 31 December 2013. The database of DAHANCA contained recordings of recurrent disease in 567 patients with primary tumors of the larynx, pharynx, oral cavity, nasal cavity, paranasal sinuses and salivary glands. A review of medical records was performed in order to update and supplement the database. Results Failures of the 567 patients were primarily in T-site (65%) followed by N-site (36%) and M-site (22%). The vast majority of the first recurrences occurred within the first years after primary treatment; 62%, 82%, and 91% within the first, second and third year, respectively. Totally, 51% were amenable for salvage treatment, and 44% benefited from salvage in terms of a complete response. Permanent tumor control was observed in 128 patients (23%) after one or two salvage attempts. The highest salvage rate was recorded in patients with primary glottic carcinoma (41%) and the lowest among hypopharyngeal cancers (2%). Asymptomatic recurrence was recorded in 12% of all recurrences and this was found to be a positive prognostic factor for disease-specific survival, as they had significantly better outcome after salvage. Conclusion Our data support the usefulness of specialized FU in terms of early detection of recurrent disease. In particular patients with silent recurrences benefited from early detection, as they had a significantly lower risk ratio of death from primary HNC.
Lomechusa paradoxa Gravenhorst 1806
Creators: name: Ferreira, Raul Nascimento
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Lomechusa
Lomechusa paradoxa

description: Lomechusa paradoxa Gravenhorst, 1806
 Insectos com o corpo castanho, cabeÇa castanha clara a preta e por vezes a combinaÇão das duas, com densa microreticulaÇão e com pubescência dourada fina e dispersa. CabeÇa com uma depressão côncava e uma pequena querena entre as antenas. Antenas curtas nunca alcanÇando a parte terminal dos élitros. Base do pronoto um pouco mais larga que a cabeÇa com margens laterais paralelas com uma pequena concavidade e cantos posteriores curtos e obtusos. Comprimento 3,7-4,5 mm. Mencionada aqui pela primeira vez para Portugal.
 Novos Registos:
  PORTUGAL: DOURO LITORAL: Porto: PaÇos de Ferreira, Pena Maior, 12-VI-1969, 1 ex. (RNFC). Este exemplar está no mesmo alfinete com um specimen de Myrmica sp. MINHO: Braga: Vieira do Minho, Serra do Gerêz, 15-IV-1973, 2 ex. (RNFC).
description: Published as part of Ferreira, Raul Nascimento, 2014, Novos dados para o conhecimento dos Lomechusini Fleming, 1821 (Coleoptera: Staphylinidae: Aleocharinae) da fauna portuguesa., pp. 183-187 in Arquivos Entomolóxicos 10 on pages 185-186, DOI: 10.5281/zenodo.12713960
Predictors of radiation-induced gastrointestinal morbidity: A prospective, longitudinal study following radiotherapy for carcinoma of the prostate
Creators: name: Yeoh, Eric K.
name: Krol, Robin
name: Varinderpal S. Dhillon
name: Botten, Rochelle
name: Matteo, Addolorata Di
name: Butters, Julie
name: Aleisha R. Brock
name: Esterman, Adrian
name: Salisbury, Carolyn
name: Fenech, Michael
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Background Chronic gastrointestinal (GI) morbidity occurs in ≥50% of patients after external beam radiotherapy (EBRT) for carcinoma of prostate (CaP). This prospective, longitudinal study examines which baseline measurements of: 1) homocysteine and micronutrients in plasma; 2) chromosome damage/misrepair biomarkers; and 3) anal and rectal dose volume metrics predict GI morbidity after EBRT. Patients and methods In total, 106 patients with CaP had evaluations of GI symptoms (modified LENT-SOMA questionnaires) before EBRT and at one month, one, two and three years after its completion. Other variables measured before EBRT were: 1) plasma concentrations of homocysteine and micronutrients including caroteinoids and selenium; 2) chromosome damage/DNA misrepair (micronuclei/nucleoplasmic bridge) indices; and 3) mean anal and rectal wall doses and volumes of anal and rectal walls receiving ≥40 Gy and ≥60 Gy. Univariate and multivariate analyzes examined the relationships among: 1) plasma levels of homocysteine and micronutrients; 2) indices of chromosome damage/DNA misrepair; and 3) mean anal and rectal wall doses and volumes of anal and rectal walls receiving ≥40 Gy and ≥60 Gy and total GI symptom scores from one month to three years after EBRT. Results Increased frequency and urgency of defecation, rectal mucous discharge and bleeding after EBRT resulted in sustained rises in total GI symptom scores above baseline at three years. On univariate analysis, total GI symptom scores were significantly associated with: 1) plasma selenium and α tocopherol; 2) micronuclei indices of DNA damage; 3) mean anal and rectal wall doses; and 4) volumes of anal and rectal wall receiving ≥40 Gy and ≥60 Gy (p = 0.08–<0.001). On multivariate analysis, only volume of anal wall receiving ≥40 Gy was significant for increased GI symptoms after EBRT (p Conclusion The volume of anal wall receiving ≥40 Gy predicts chronic GI morbidity after EBRT for CaP.
Fiber Composition in Sows’ Diets Modifies Clostridioides difficile Colonization in Their Offspring
Creators: name: Grześkowiak, Łukasz
name: Saliu, Eva-Maria
name: Martínez-Vallespín, Beatriz
name: Wessels, Anna Grete
name: Männer, Klaus
name: Vahjen, Wilfried
name: Zentek, Jürgen
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: dietary fiber
subject: gut microbiota
subject: sows
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Dietary fiber has a potential to modulate the gut microbiota in sows. We hypothesized that a maternal diet rich in either high- or low-fermentable fiber during gestation and lactation influences Clostridioides difficile gut colonization in suckling piglets. Twenty sows were fed gestation and lactation diets enriched with either high-fermentable sugar beet pulp (SBP) or low-fermentable lignocellulose (LNC) fibers. C. difficile, toxin B (TcdB), fecal score, microbial abundance (16S-rDNA sequencing) and metabolites were measured in the feces from the sows and their piglets. C. difficile concentration was higher in piglets from the sows fed LNC than SBP along the study (P ≤ 0.05). Higher prevalence of C. difficile was noted in three-week-old piglets from sows fed LNC vs. SBP (45% vs. 0%, P = 0.001). TcdB prevalence was higher in six-day-old piglets from the sows fed LNC vs. SBP (60% vs. 17%, P = 0.009). In sows, fecal microbial metabolites were higher in SBP than LNC, while C. difficile concentration showed no difference. Higher microbial diversity Shannon index was noted in sows from SBP vs. LNC one week before parturition and at the parturition (P ≤ 0.05). Piglets from SBP vs. LNC tended to have higher microbial diversity Shannon index at two and three weeks of age. Diets enriched with high-fermentable fiber compared to low-fermentable fiber in sows reduced C. difficile colonization in their piglets. Susceptibility to colonization by C. difficile in neonatal piglets can be modulated by the sows’ diet, supporting the hypothesis of the early microbial programming in the offspring and the importance of the sow-piglet couple.
Dendritic Polyglycerol-Conjugated Gold Nanostars for Metabolism Inhibition and Targeted Photothermal Therapy in Breast Cancer Stem Cells
Creators: name: Pan, Yuanwei
name: Zhou, Suqiong
name: Liu, Chuang
name: Ma, Xuehua
name: Xing, Jie
name: Parshad, Badri
name: Li, Wenzhong
name: Wu, Aiguo
name: Haag, Rainer
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: breast cancer stem cells
subject: dendritic polyglycerol
subject: gold nanostars
subject: metabolism inhibition
subject: photothermal therapy
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Breast cancer stem cells (CSCs) are believed to be responsible for tumor initiation, invasion, metastasis, and recurrence, which lead to treatment failure. Thus, developing effective CSC-targeted therapeutic strategies is crucial for enhancing therapeutic efficacy. In this work, GNSs-dPG-3BP, TPP, and HA nanocomposite particles are developed by simultaneously conjugating hexokinase 2 (HK2) inhibitor 3-bromopyruvate (3BP), mitochondrial targeting molecule triphenyl phosphonium (TPP), and CSCs targeting agent hyaluronic acid (HA) onto gold nanostars-dendritic polyglycerol (GNSs-dPG) nanoplatforms for efficient eradication of CSCs. The nanocomposite particles possess good biocompatibility and exhibit superior mitochondrial-bound HK2 binding ability via 3BP to inhibit metabolism, and further induce cellular apoptosis by releasing the cytochrome c. Therefore, it enhanced the therapeutic efficacy of CSCs-specific targeted photothermal therapy (PTT), and achieved a synergistic effect for the eradication of breast CSCs. After administration of the synergistic treatment, the self-renewal of breast CSCs and the stemness gene expression are suppressed, CSC-driven mammosphere formation is diminished, the in vivo tumor growth is effectively inhibited, and CSCs are eradicated. Altogether, GNSs-dPG-3BP, TPP, and HA nanocomposite particles have been developed, which will provide a novel strategy for precise and highly efficient targeted eradication of CSCs.
SEGMENTAL LINING GROUT SOLUTIONS FOR THE CONSTRUCTION OF TUNNELS AND MINING GALLERIES
Creators: name: Anischenko V.I., Atrushkevich V.A.
Publisher: name: TuEngr Group
Year: 2020
Subjects: Tunnel Engineering, Concrete/Cement Technology.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 3, 11A03Q: 1-7
The Proton Electromagnetic Generalized Polarizabilities
Creators: name: Sparveris, Nikos
Publisher: name: arXiv
Year: 2024
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The electromagnetic polarizabilities are fundamental properties of the proton that characterize its response to an external EM field. The generalization of the EM polarizabilities to non-zero four-momentum transfer opens up a powerful path to study the internal structure of the proton. They map out the spatial distribution of the polarization densities in the proton, provide access to key dynamical mechanisms that contribute to the electric and the magnetic polarizability effects, and allow to determine fundamental characteristics of the system, such as the electric and the magnetic polarizability radii. This article reviews the knowledge of the proton EM generalized polarizabilities. An introduction is given to the basic concepts and to the theoretical framework, that is then followed by a discussion that emphasizes the recent developments and findings of the Virtual Compton scattering experiments and future perspectives on the topic.
description: Review Article, Frontiers in Physics
It is better when expected: aligning speech and motor rhythms enhances verbal processing
Creators: name: Falk, Simone
name: Bella, Simone Dalla
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Rhythm is a powerful way to shape the processing of complex sounds such as speech or music by generating temporal expectancies in the listener. Here, we investigated if multisensory expectancies generated by aligning speech and motor rhythms may enhance verbal processing. Participants listened to rhythmically regular German sentences and detected word changes occurring on stressed or unstressed syllables. Participants were cued to produce finger taps simultaneously with the auditory speech rhythm. Finger taps were aligned or misaligned with stressed syllables. Detection of word changes was facilitated when manual movements were temporally aligned with the auditory speech rhythm. Moreover, motor alignment enhanced sensitivity to detect changes on stressed syllables compared to a perceptual control condition. Thus, rhythmic speech structure reinforced by concurrent movement in multisensory contexts has beneficial effects on verbal processing. This finding lends support to models of expectancy-driven speech processing.
Lomechusa emarginata
Creators: name: Ferreira, Raul Nascimento
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Lomechusa
Lomechusa emarginata

description: Lomechusa emarginata (Paykull, 1789)
 Espécie apresentando grande variaÇão de cor, desde castanho avermelhado claro a escuro. CabeÇa e pronoto mais escuros que os élitros e ambos baÇos. Tergitos amarelo acastanhados e brilhantes. CabeÇa com uma depressão côncava entre os olhos. Antenas compridas alcanÇando, pelo menos, a extremidade dos élitros. Base do pronoto estreita mas um pouco mais larga que a cabeÇa, com as margens laterais projectadas posteriormente, agudas na base e com depressões. Disco do pronoto ligeiramente convexo. Comprimento 3,5-4,5 mm. Referida aqui pela primeira vez para Portugal.
 Novos Registos:
 PORTUGAL: BEIRA LITORAL: Coimbra: Coimbra, Pinhal de Marrocos, 5-VII-1969, 1 ex. (RNFC). Leiria: Ansião, Avelar (Serra de Ansião), 15-VII-1970, 1 ex. (RNFC).
description: Published as part of Ferreira, Raul Nascimento, 2014, Novos dados para o conhecimento dos Lomechusini Fleming, 1821 (Coleoptera: Staphylinidae: Aleocharinae) da fauna portuguesa., pp. 183-187 in Arquivos Entomolóxicos 10 on page 186, DOI: 10.5281/zenodo.12713960
MEDIA REPRESENTATION OF CHINA: FRAMING ANALYSIS OF HONG KONG DISPUTES IN PAKISTANI MEDIA
Creators: name: Muhammad Aftab Madni Memon, Shen Hui
Publisher: name: TuEngr Group
Year: 2020
Subjects: China-Pakistan ties
News framing
War/Peace Journalism
Dispute reporting
Hong Kong protest.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 3, 11A03A: 1-14
Symbiotes latus Redtenbacher 1849
Creators: name: Irurzun, José Ignacio Recalde
name: Moreno, Antonio Fermín San Martín
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Anamorphidae
Symbiotes
Symbiotes latus

description: Symbiotes latus Redtenbacher, 1849
 Se trata de un insecto oval-oblongo, de unos 2 mm, enteramente de color rojizo ferruginoso claro, con pubescencia amarilla y maza antenar de tres artejos. Tarsos tetrámeros con el tercer artejo visible y libre. Su escutelo es casi semicircular y la base pronotal es tan ancha como la base elitral (Figura 1).
 Material estudiado:
 Navarra: Parque Natural del Señorío de Bértiz (Arbaiztegi), V-2007, 1 ej., mediante trampa de ventana en un viejo robledal; Oroz-Betelu (Olaldea, Araden), VI-2010, 1 ej., mediante trampas de interceptación de vuelo en un hayedo decadente; Garralda (Lapizea), VI-2010, 1 ej., mediante trampas de interceptación de vuelo en un rodal de haya y roble.
  En las tres localidades se ha capturado también S. gibberosus (Figura 2), especie extendida por el norte de Navarra de la que S. latus se separa, entre otros caracteres, por ser menos convexo, por su talla algo mayor, las estrías elitrales con puntuación simple y marcada que forma hileras bien definidas, y el perfil general de su cuerpo, que es más paralelo.
  Symbiotes latus habita en diversos países de la mitad occidental de Europa (Alemania, Austria, Bélgica, Dinamarca, Francia, Gran Bretaña, Holanda, Italia, Liechtenstein, Luxemburgo y Suiza (Tomaszewska, 2007). Fuente (1928) menciona la presencia de S. latus en los Pirineos Orientales franceses, por lo que su presencia en los bosques ḣmedos de la vertiente española no es sorprendente.
  Al parecer, y al igual que S. gibberosus, se trata de un elemento micófago y mirmecófilo, asociado a cavidades arbóreas (Schmidl & Bussler, 2004; Shockley & Tomaszewska, 2007).
description: Published as part of Irurzun, José Ignacio Recalde & Moreno, Antonio Fermín San Martín, 2014, Algunos Cucujoidea del norte de Navarra nuevos o poco conocidos para la fauna ibérica (Coleoptera: Endomychidae, Cerylonidae, Biphyllidae, Laemophloeidae & Erotylidae)., pp. 175-180 in Arquivos Entomolóxicos 10 on page 176, DOI: 10.5281/zenodo.12713962
openEO D24: First iteration of use case chains
Creators: name: Gößwein, Bernhard
name: Navacchi, Claudio
name: Zellner, Peter
name: Milenković, Milutin
name: Mîrt, Mihai-Andrei
name: Masiliūnas, Dainius
name: Verbesselt, Jan
name: Schramm, Matthias
Publisher: name: Zenodo
Year: 2020

description: This deliverable of the openEO project provides descriptions about the use case workflows, as agreed upon in the project proposal.
description: {"references": ["Nguyen, Duy; Clauss, Kersten; Cao, Senmao; Naeimi, Vahid; Kuenzer, Claudia; Wagner, Wolfgang (2015). Mapping Rice Seasonality in the Mekong Delta with Multi-Year Envisat ASAR WSM Data. In: Remote Sensing, 7 (12), pp 15868-15893. doi: 10.3390/rs71215808", "Verbesselt, Jan; Hyndman, Rob; Newnham, Glenn; Culvenor, Darius (2010). Detecting trend and seasonal changes in satellite image time series. In: Remote Sensing of Environment, 114 (1), pp 106-115. doi: 10.1016/j.rse.2009.08.014"]}
Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study
Creators: name: Premkumari Kumarathasan
name: Vincent, Renaud
name: Bielecki, Agnieszka
name: Blais, Erica
name: Blank, Katrin
name: Dharani Das
name: Karthikeyan, Subramanian
name: Cakmak, Sabit
name: Fisher, Mandy
name: Arbuckle, Tye
name: Fraser, William
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects. Methods and results: Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF). Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.
Identification of β-glucosidase 1 as a biomarker and its high expression in hepatocellular carcinoma is associated with resistance to chemotherapy drugs
Creators: name: Zhang, Ye
name: Kuiyu Zhu
name: Xiaofei Miao
name: Xingqian Hu
name: Wang, Tong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 60506 Virology

description: Context and objective: Long-term prognosis of hepatocellular carcinoma (HCC) patients is challenging, and novel biomarkers are needed to predict patient risk and serve as potential therapeutic target. Results: We found β-glucosidase 1 is significantly overexpressed and activated in primary HCC tissue and multiple HCC cell lines. β-Glucosidase 1 expression is associated with predicting prognosis of HCC patients under chemotherapy. Silencing β-glucosidase 1 inhibits growth and survival of HCC cells, with preferential inhibitory effects on high β-glucosidase 1-expressing cells. Combination of chemo drug with β-glucosidase 1 inhibitor sensitized HCC cells to chemotherapy. Conclusion: Our data support β-glucosidase 1 as a HCC biomarker due to its prognosis significance.
MAJOR FACTORS DETERMINING ACCUMULATION OF TOXIC ELEMENTS BY BEES AND HONEY PRODUCTS
Creators: name: Murashova E.A., Tunikov G.M.
Publisher: name: TuEngr Group
Year: 2020
Subjects: Honey bees
Honey contamination
Heavy metals contamination
Ecosystem monitoring
Bee pollen
Bee bread
Ecotoxicity
Propolis
Honey products
Toxic contamination
Bee body contamination.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 3, 11A03N: 1-14.
Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes
Creators: name: Xiaoyan Liu
name: Yanqiu Liu
name: Mengchun Cheng
name: Hongbin Xiao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Time-course metabolic changes of aristolochic acid nephrotoxicity (AAN) was investigated using acute AAN HK-2 model. And the AAN-related biomarkers were selected. In the results, 11 potential identified biomarkers were selected and validated using multivariate method combined with time-course analysis. Several metabolic pathways, including vitamin metabolism, lipids acalytion, trytophan metabolism and protein degradation were found to be associated with AAN pathology. This research will provide a valuable reference for the discovery of more potential biomarkers of AAN progression in clinic.
The Complexity of Computing Robust Mediated Equilibria in Ordinal Games
Creators: name: Conitzer, Vincent
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: Usually, to apply game-theoretic methods, we must specify utilities precisely, and we run the risk that the solutions we compute are not robust to errors in this specification. Ordinal games provide an attractive alternative: they require specifying only which outcomes are preferred to which other ones. Unfortunately, they provide little guidance for how to play unless there are pure Nash equilibria; evaluating mixed strategies appears to fundamentally require cardinal utilities.
 In this paper, we observe that we can in fact make good use of mixed strategies in ordinal games if we consider settings that allow for folk theorems. These allow us to find equilibria that are robust, in the sense that they remain equilibria no matter which cardinal utilities are the correct ones -- as long as they are consistent with the specified ordinal preferences. We analyze this concept and study the computational complexity of finding such equilibria in a range of settings.
Benchmarking PID and BELBIC Controllers for Electric Vehicle Speed Regulation Under Realistic Driving Conditions
Creators: name: Ganneboina Raju, Dr.G.N.Srinivas
Publisher: name: Zenodo
Year: 2025

description: This study presents a comparative analysis of Proportional-Integral-Derivative (PID) and Brain Emotional Learning Based Intelligent Control (BELBIC) strategies for electric vehicle (EV) speed optimization using MATLAB/Simulink. The performance of both controllers is evaluated under two standardized drive cycles: ECE-R15 (Urban Driving Cycle) and New York Composite (NYComp). ECE-R15 simulates typical European urban driving, while NYComp, also known as the New York Bus Composite (NYBC) cycle, reflects real-world heavy-duty vehicle operation in New York City and is a compressed version of the U.S. EPA’s unfiltered bus test cycle. These drive cycles offer a comprehensive testing environment to assess controller performance. Key performance indicators—response time, steady-state error, and robustness—are analyzed to determine each controller's effectiveness. Results highlight the strengths and limitations of PID and BELBIC approaches, offering insight into their practical use for urban EV applications. This research supports the advancement ofintelligent EV control systems using MATLAB/Simulink, promoting improved efficiency and reliability in urban transportation.
title: 02_1539
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Abundance and functional roles of intrinsic disorder in the antimicrobial peptides of the NK-lysin family
Creators: name: Yacoub, Haitham A.
name: Al-Maghrabi, Omar A.
name: Ekram S. Ahmed
name: Uversky, Vladimir N.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: NK-lysins are antimicrobial peptides (AMPs) that participate in the innate immune response and also have several pivotal roles in various biological processes. Such multifunctionality is commonly found among intrinsically disordered proteins. However, NK-lysins have never been systematically analyzed for intrinsic disorder. To fill this gap, the amino acid sequences of NK-lysins from various species were collected from UniProt and used for the comprehensive computational analysis to evaluate the propensity of these proteins for intrinsic disorder and to investigate the potential roles of disordered regions in NK-lysin functions. We analyzed abundance and peculiarities of intrinsic disorder distribution in all-known NK-lysins and showed that many NK-lysins are expected to have substantial levels of intrinsic disorder. Curiously, high level of intrinsic disorder was also found even in two proteins with known 3D-strucutres (NK-lysin from pig and human granulysin). Many of the identified disordered regions can be involved in protein–protein interactions. In fact, NK-lysins are shown to contain three to eight molecular recognition features; i.e. short structure-prone segments which are located within the long disordered regions and have a potential to undergo a disorder-to-order transition upon binding to a partner. Furthermore, these disordered regions are expected to have several sites of various posttranslational modifications. Our study shows that NK-lysins, which are AMPs with a set of prominent roles in the innate immune response, are expected to abundantly possess intrinsically disordered regions that might be related to multifunctionality of these proteins in the signal transduction pathways controlling the host response to pathogenic agents.
The typology of the American metropolis: monocentricity, polycentricity, or generalized dispersion?
Creators: name: Hajrasouliha, Amir H.
name: Hamidi, Shima
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Although the spatial structure of employment in large US metropolitan regions is a well-researched topic, few studies focus on medium-sized and small US metropolitan regions. Consequently, there is no overall typology relating small-to-medium urban form to employment distribution. We address this gap by investigating the spatial structure of employment in 356 metropolitan regions. We conceptualize six typologies based on three categories that have overlapping properties: “monocentricity,” “polycentricity,” and “generalized dispersion.” The study has three main findings. First, the three types of urban form that we identify as “hybrid” outnumber the three “pure” types by almost four to one. Second, job dispersion is a dominant characteristic in almost 70% of all metropolitan statistical areas (MSAs) (including the hybrid types), and polycentricity (56.7% of MSAs) is somewhat more common than monocentricity. Third, there is a strong relationship between population size and density. The population of medium-sized metropolitan areas is generally more dispersed than that of small and large metropolitan areas. Polycentricy emerges mostly in large metropolitan regions, while monocentrity is found in both small and large metropolitan regions.
Taxonomy and molecular systematics of three oligotrich (s.l.) ciliates including descriptions of two new species, Strombidium guangdongense sp. nov. and Strombidinopsis sinicum sp. nov. (Protozoa, Ciliophora)
Creators: name: Weiwei Liu
name: Dapeng Xu
name: Honggang Ma
name: Al-Farraj, Saleh A.
name: Warren, Alan
name: Zhenzhen Yi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: In this study we investigated the morphology of three oligotrich (s.l.) ciliates, Strombidium guangdongense sp. nov., Cyrtostrombidium paralongisomum Tsai et al., 2015 and Strombidinopsis sinicum sp. nov. Strombidium guangdongense sp. nov. is characterized by its elongate obconical to obovoidal body shape and widely spaced dikinetids in the girdle and ventral kineties. Another new species, Strombidinopsis sinicum sp. nov. is diagnosed by its small size and semi-globular body shape without mineral envelopes. Some additional morphological data of the recently described species Cyrtostrombidium paralongisomum Tsai et al., 2015, such as the endoral membrane, are supplied based on our population. We also analysed the molecular phylogeny of each species based on small subunit rRNA (SSU rRNA) gene sequence data. The monophyly of Cyrtostrombidium is supported by our phylogenetic analyses, but the monophyly of Strombidinopsis and of the family Strombidinopsidae are both rejected by AU tests. In addition, Strombidium species have a tail branch separately from one another in phylogenetic trees, whereas strombidiids with a pigment spot group together, suggesting the latter character is a synapomorphy for this group of strombidiids. http://zoobank.org/urn:lsid:zoobank.org:act:35FE2AFD-A582-4885-BD01-48901E4C76C4 http://zoobank.org/urn:lsid:zoobank.org:act:E9D4A497-DAD6-4AA0-A044-A5A1D2C1A057
A novel network alignment algorithm for extracting densest connected subgraphs in dual networks.
Creators: name: PietroHiram Guzzi
name: Salerno, Emanuel
name: Tradigo, Giuseppe
name: Veltri, Pierangelo
Publisher: name: F1000 Research Limited
Year: 2020

description: A novel network alignment algorithm for extracting densest connected subgraphs in dual networks.
A new sesquiterpene from the gorgonian coral Menella sp.
Creators: name: Peng, Qi
name: Liu, Fen
name: Sun, Huan
name: Liao, Xiao-Jian
name: Mei-Ran Feng
name: Liu, Ting-Ting
name: Zheng-Xiong Xu
name: Zhang, Jun
name: Xu, Shi-Hai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: A new sesquiterpene named menecubebane B (1) and a known analogue (2) were isolated from the gorgonian coral Menella sp. Their structures were elucidated by the extensive analyses of spectroscopic data and by the comparison with related literature. Cytotoxic effect against both Eca9706 and HeLa cell lines was evaluated, revealing 1 exhibited moderate cytotoxicity against the two cell lines involved with IC50 values being 20.8 and 30.6 μM, respectively.
Synthesis of new ferrocenyldithiophosphonate derivatives: electrochemical, electrochromic, and optical properties
Creators: name: Ayranci, Rukiye
name: Ak, Metin
name: Seyda Ocal
name: Karakus, Mehmet
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Hematology

description: In this study, three ferrocenyl dithiophosphonate derivatives were synthesized and characterized by elemental analyses, IR, and NMR (1H-, 31P-) spectroscopy. Electroactivities of synthesized molecules were determined by cyclic voltammetry experiments. It was shown that all molecules were electroactive and only one of them that contained conjugated structure could polymerized by electrochemical experiments. Characterization of electrosynthesized metallopolymer was realized and electrochromic and spectroelectrochemical properties were investigated. The onset energy for the π–π* transition (electronic band gap), HOMO, and LUMO energy levels were calculated as 2.31, −4.44, and 2.13 eV, respectively. Switching time and optical contrast values of metallopolymer were found as 1.5 s and 41% at 435 nm, respectively, whereas these values were found as 2.5 s and 40%, respectively, at 700 nm.
A Novel Framework for Weather-Induced Electromagnetic Events
Creators: name: Wilcox, Clyde Jermaine
Publisher: name: Zenodo
Year: 2025

description: This paper introduces an original theoretical framework redefining weather as an emergent electromagnetic process, driven by the interaction between atmospheric magnetic “data” and electric “potential.” Rather than viewing storms as purely thermodynamic events, this interdisciplinary approach treats them as system-level information discharges—akin to neurological firings—governed by pressure, configuration, and coherence. Drawing from systems theory, atmospheric physics, and bio-electromagnetism, the paper proposes that lightning and thunder are not random results of instability, but structured consequences of electromagnetic information release. This paradigm opens new pathways for predictive modeling, disaster prevention, and restoring planetary electromagnetic balance. Authored by Clyde Jermaine Wilcox, independent researcher in advanced theoretical physics and mathematics.

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title: Berichte über Landwirtschaft - Zeitschrift für Agrarpolitik und Landwirtschaft, Aktuelle Beiträge
title: Aktuelle Beiträge
titleType: AlternativeTitle
Creators: name: Berichte über Landwirtschaft-Zeitschrift Für Agrarpolitik Und Landwirtschaft
Publisher: name: Berichte über Landwirtschaft - Zeitschrift für Agrarpolitik und Landwirtschaft
Year: 2024

description: „ErnteSicher“: Unter dem Regenschirm der Subventionen – Einstellungen und Herausforderungen sächsischer Bauern gegenüber subventionierter Mehrgefahrenversicherungen
Why should we ever automate moral decision making?
Creators: name: Conitzer, Vincent
Publisher: name: arXiv
Year: 2024
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: While people generally trust AI to make decisions in various aspects of their lives, concerns arise when AI is involved in decisions with significant moral implications. The absence of a precise mathematical framework for moral reasoning intensifies these concerns, as ethics often defies simplistic mathematical models. Unlike fields such as logical reasoning, reasoning under uncertainty, and strategic decision-making, which have well-defined mathematical frameworks, moral reasoning lacks a broadly accepted framework. This absence raises questions about the confidence we can place in AI's moral decision-making capabilities.
 The environments in which AI systems are typically trained today seem insufficiently rich for such a system to learn ethics from scratch, and even if we had an appropriate environment, it is unclear how we might bring about such learning. An alternative approach involves AI learning from human moral decisions. This learning process can involve aggregating curated human judgments or demonstrations in specific domains, or leveraging a foundation model fed with a wide range of data. Still, concerns persist, given the imperfections in human moral decision making.
 Given this, why should we ever automate moral decision making -- is it not better to leave all moral decision making to humans? This paper lays out a number of reasons why we should expect AI systems to engage in decisions with a moral component, with brief discussions of the associated risks.
A review of mechanical properties of concrete with recycled aggregates
Creators: name: S. Reza Salimbahrami
name: Shakeri, Reza
name: Rezapour, Mohammad Ali
Publisher: name: F1000 Research Limited
Year: 2020

description: According to the results of the census, the average population growth rate compared to 1390 has reached 24.1%. At the same time, the positive urban population growth rate has been 97.1% and the negative rural population growth rate has been negative 0.73%. Estimates by the Ministry of Housing and Urban Development show that the percentage of Iran's urban population has reached more than 73 percent, while the global average of urbanization is reported at 60 percent. Therefore, with the increasing population growth, the need to provide housing also increases; which - to reduce part of the demand, the existing buildings have been demolished and renovated, which in turn leads to an increase in construction waste on a large scale. For example, the daily production of soil and debris in Tehran is 5 times that of municipal waste and 40,000 tons of construction debris is produced daily in this city. On the other hand, our country has suitable mines for the preparation of raw materials for making concrete, but its full use and reliance on long-term goals will be dangerous and harmful. Therefore, researchers proposed a solution to this problem and the optimal use of recycled materials and construction debris called recycled concrete. The use of recycled concrete from old buildings has benefited humans in recent decades, and in 1980, for example, Minsolta's transportation department covered 16 miles of a flat track with recycled concrete, and then It is estimated that approximately $ 600,000 has been saved in this project. Studies also show that construction waste makes up 50% of the total volume of waste materials in the world and in the European Union, 500 kg of construction waste is produced per capita per year. Concrete from the demolition of highways and reinforced concrete buildings in the United States and Europe has been in the recycling industry for nearly 20 years. Recycling waste from demolition for new buildings can be a good solution to this problem. Beating and grinding materials from the demolition of reinforced concrete buildings can reduce the volume of waste by about 80%. While reducing waste is beneficial, recycling it produces products that can be sold or used in other work. Therefore, due to this work and by replacing recycled aggregates with natural aggregates, the damage to the environment is reduced. If this huge amount of waste is recycled, the amount of land expected to be disposed of will be reduced and the available natural stone resources and mines will not be used up quickly, so recycling this large amount of waste will not only help preserve natural resources, but also the crisis. Growth also solves the space needed to dispose of waste. Research on recycled concrete began 20 years ago and the results are almost the same. The results indicate that recycled aggregates have an effect on the deformation and compressive strength of recycled concrete and will increase and decrease it, respectively.
Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.
Creators: name: Sun, Huan
name: Liu, Fen
name: Mei-Ran Feng
name: Peng, Qi
name: Liao, Xiao-Jian
name: Liu, Ting-Ting
name: Zhang, Jun
name: Xu, Shi-Hai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: A new polyhydroxysterol, (22E)-24-methylenecholestane-22-ene-3β,5α,6β-triol (1), together with four known analogues (2–5) were isolated from the South China Sea soft coral Sinularia sp. Their structures were elucidated by spectroscopic analyses and comparison with previously reported data. All these compounds exhibited cytotoxic effect against both HepG2 and HeLa cell lines with IC50 values ranging from 8.36 to 37.30 μM. Preliminary structure–activity relationship study identified that the presence of double bonds in the side chains of these polyhydroxysterols significantly reduced the biological effect obtained.
The V-Lab VR Educational Application Framework
Creators: name: Zafeiropoulos, Vasilis
name: Anastassakis, George
name: Orphanoudakis, Theophanis
name: Kalles, Dimitris
name: Fanariotis, Anastasios
name: Fotopoulos, Vassilis
Publisher: name: arXiv
Year: 2024
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: This paper presents the V-Lab, a VR application development framework for educational scenarios mainly involving scientific processes executed in laboratory environments such as chemistry and biology laboratories. This work is an extension of the Onlabs simulator which has been developed by the Hellenic Open University as a distance teaching enabler for similar subjects, helping to alleviate the need for access to the physical laboratory infrastructure; thus, shortening training periods of students in the laboratory and making their training during the periods of physical presence more productive and secure. The extensions of the Onlabs to deliver an enhanced and modular framework that can be extended to multiple educational scenarios is the work performed within the context of the European project XR2Learn (Leveraging the European XR industry technologies to empower immersive learning and training).
description: 7 pages, 3 figures, Proceedings of the 25th International Conference on Mobile Human-Computer Interaction (MobileHCI '23)