cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review
Creators: name: Wang, Qing-Zhi
name: Mao, Yu-Ping
name: Raat, Hein
name: Sun, Chang
name: Zhou, Huan
name: Wu, Yu-Ju
name: Adhikari, Sasmita Poudel
name: Sylvia, Sean
name: Meng, Sha
name: Rozelle, Scott
name: Ye, Rui-Xue
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: BACKGROUND: The coronavirus disease (COVID-19) has been identified as the cause of an outbreak of respiratory illness in Wuhan, Hubei Province, China beginning in December 2019. As of 31 January 2020, this epidemic had spread to 19 countries with 11 791 confirmed cases, including 213 deaths. The World Health Organization has declared it a Public Health Emergency of International Concern.  METHODS: A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley. In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. The research domains, dates of publication, journal language, authors' affiliations, and methodological characteristics were included in the analysis. All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.  RESULTS: Most of the publications were written using the English language (89.2%). The largest proportion of published articles were related to causes (38.5%) and a majority (67.7%) were published by Chinese scholars. Research articles initially focused on causes, but over time there was an increase of the articles related to prevention and control. Studies thus far have shown that the virus' origination is in connection to a seafood market in Wuhan, but specific animal associations have not been confirmed. Reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. Preventive measures such as masks, hand hygiene practices, avoidance of public contact, case detection, contact tracing, and quarantines have been discussed as ways to reduce transmission. To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. CONCLUSIONS: There has been a rapid surge in research in response to the outbreak of COVID-19. During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. Although these studies are relevant to control the current public emergency, more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short- and long-term.
A Similarity-based Framework for Classification Task
Creators: name: Ma, Zhongchen
name: Chen, Songcan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Similarity-based method gives rise to a new class of methods for multi-label learning and also achieves promising performance. In this paper, we generalize this method, resulting in a new framework for classification task. Specifically, we unite similarity-based learning and generalized linear models to achieve the best of both worlds. This allows us to capture interdependencies between classes and prevent from impairing performance of noisy classes. Each learned parameter of the model can reveal the contribution of one class to another, providing interpretability to some extent. Experiment results show the effectiveness of the proposed approach on multi-class and multi-label datasets
description: Accepted by TKDE2022
Development of bio-based pigments for paints and coatings
Creators: name: Park, Young-Kyoung
Publisher: name: Zenodo
Year: 2024

description: Webinar “Painting a Bio-based Future with PERFECOAT”

Achievements and current challenges of creating sustainable solutions in paints and coatings - 27 August 2024, 13:00 to 15:00 CEST, online

The EU- & CBE JU funded research project PERFECOAT project aims to develope high-performance, bio-based industrial wood and decorative paints and coatings with a minimum of 25% bio-based components. Successful solutions will support the shift towards sustainable and eco-friendly alternatives in the paint and coatings industry and thus the pursuit of a climate-neutral Europe.

On 27 August 2024, from 13:00 to 15:00 CEST, the PERFECOAT team will present its achievements and latest results in a final webinar, while also discussing the identified obstacles and challenges. This event will delve into various key accomplishments and present crucial results that will enable industry stakeholders to opt for greener solutions in their own formulations and applications. 

Development of Bio-Based Binders: Discover how alginates, xanthan, and xylan have been successfully utilized to create effective bio-based binders.

Natural Pigment and Dye Innovations: Learn about the sustainable colorants produced from yeast and fungi, offering eco-friendly alternatives to traditional pigments.

 

Enhanced Paint Properties: Explore the advancements in paint durability and performance through the integration of functional nano materials and fillers.

Sustainability and Safety Assessment: Gain insights into comprehensive assessments comparing the sustainability, social sustainability, health and safety, toxicology and performance of these bio-based paint components with conventional fossil-based products.

Formulation and Testing: Learn how the performance of the final formulations is tested and evaluated  in different applications. 

This online events offers the opportunity to meet the partners online, ask live questions and learn more about the bio-based solutions in the paint and coatings industry.  

Agenda:

13:00 Introduction PERFECOAT Project (Alexander Wentzel, SINTEF)

13:05 Binders (Morten Frøseth, SINTEF; Srdjan Gavrilović, TalTech)

13:25 Pigments (Young Park, INRAE)

13:45 Filler & Functional Nano Material (Brian Wabende, BioEnvision)

14:05 Safety and Sustainability of Bio-based Coatings (Andy Booth, SINTEF OCEAN; Kamal Azrague, SINTEF)

14:25 Results on End-use Applications (Christine Louis, Evonik; Roland Steinrücken, Remmers)

14:45 Q&A

15:00 Closing remarks (Alexander Wentzel, SINTEF)

The PERFECOAT project receives funding from the Bio-based Industries Joint Undertaking (JU) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101022370. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Bio-based Industries Consortium.
Unmet Social Needs And Worse Mental Health After Expiration Of COVID-19 Federal Pandemic Unemployment Compensation
Creators: name: Basu, Sanjay
name: Berkowitz, Seth A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Federal Pandemic Unemployment Compensation (FPUC) provided unemployment insurance beneficiaries an extra $600 a week during the unprecedented economic downturn during the coronavirus disease 2019 (COVID-19) pandemic, but it initially expired in July 2020. We applied difference-in-differences models to nationally representative data from the Census Bureau’s Household Pulse Survey to examine changes in unmet health-related social needs and mental health among unemployment insurance beneficiaries before and after initial expiration of FPUC. The initial expiration was associated with a 10.79-percentage-point increase in risk for self-reported missed housing payments. Further, risk for food insufficiency, depressive symptoms, and anxiety symptoms also increased among households that reported receiving unemployment insurance benefits, relative to the period when FPUC was in effect. As further unemployment insurance reform is debated, policy makers should recognize the potential health impact of unemployment insurance.
Population-Level Death Rates From Novel Coronavirus (COVID-19) in South Korea
Creators: name: Mann, Caroline
name: Yang, JaeWon
name: Soneji, Samir
name: Beltrán-Sánchez, Hiram
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: South Korea was among the first countries to report a case of the novel coronavirus (COVID-19). As of August 14, 2020, South Korea reported 14 873 confirmed cases and 305 deaths from COVID-19. We collected the number of laboratory-confirmed cases and deaths by age from the Korean Centers for Disease Control and Prevention. We estimated population-level death rates by fitting a logistic regression model using Firth’s bias reduction method. We calculated the age-standardized death rate (ASDR) varying the COVID-19 prevalence and level of death undercount. Estimated population-level death rates of COVID-19 (deaths per 100 000 person-years) increased with age: 0.1 among 30 to 39 year olds, 1.1 among 60 to 69 year olds, and 14.5 among ≥80 year olds. The ASDR (deaths per 100 000 person-years) was 0.9 based on the current deaths and population-level prevalence of 0.03%. If the prevalence increased to 0.6% and 30% of COVID-19 deaths had not been reported, the ASDR would further increase to 13.7 to become the seventh leading cause of death. Currently, the population-level mortality burden of COVID-19 in South Korea, as measured by the ASDR, was relatively low compared with other causes but could increase substantially if the prevalence increases from another outbreak or COVID-19 deaths were undercounted.
Training "Pivots" from the Pandemic: Lessons Learned Transitioning from In-Person to Virtual Synchronous Training in the Clinical Scholars Leadership Program
Creators: name: Rosenberg, Angela
name: Dave, Gaurav
name: Henry, Ellison
name: Brandert, Kathleen
name: Noble, Cheryl C.
name: Donnald, Katherine
name: Walker, Madison R.
name: Green, Melissa A.
name: Corbie-Smith, Giselle
name: Fernandez, Claudia S. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Introduction: Since the inception of distance-based teaching modalities, a debate has ensued over the quality of online versus in-person instruction. Due to the COVID-19 pandemic, a number of teaching environments-including leadership development trainings for post-graduate learners-have been thrust into exploring the virtual learning environment more thoroughly. One three-year leadership development program for interdisciplinary healthcare professionals transitioned three simultaneous leadership intensives from in-person to online in the spring of 2020. Methods: Documented changes in overall training length, session length, and session format are described. Further, evaluative data were collected from participants at both retreats via post-session surveys. Ninety-three participants attended the 2019 retreat, and 92 participants attended the 2020 virtual retreat. Quantitative data of three rating questions per session are reported: 1) overall session satisfaction, 2) participants' reported knowledge gain, and 3) participants' reported ability gain. Qualitative data were obtained via two open-ended feedback questions per session. Results: In comparing pre/post scores for knowledge and ability, participants had meaningful (and in some cases higher) self-reported gains in knowledge and ability measures in the online environment, as compared to the in-person environment. Participants reported statistically significant gains in all sessions for both knowledge and ability. Qualitative data of participant feedback identified a number of positive themes similar across the in-person and virtual settings. Negative or constructive feedback of the virtual setting included time constraint issues (eg too much content in one session, a desire for more sessions overall), technical difficulties, and the loss of social connection and networking with fellow participants as compared to in-person trainings. Discussion: While meaningful shifts in knowledge and ability ratings indicate that the transition to successful online learning is possible, several disadvantages remain. The preparation time for both faculty and participants was considerable, there is a need to reduce overall content in each session due to time restraints, and participants indicated feeling the loss of one-on-one connections with their peers in the training. Lessons learned of transitioning leadership training from in-person to an online experience are highlighted.
(4257) Francis Henry Jones
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Magnetic resonance detection of gas microbubbles via hyperCEST: a path toward a dual modality contrast agent
Creators: name: McHugh, Christian T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Gas microbubbles are an established clinical ultrasound contrast agent. They could also become a powerful MR intravascular contrast agent, but their low susceptibility-induced contrast requires high circulating concentrations or the addition of exogenous paramagnetic nanoparticles for MR detection. In order to detect clinical in vivo concentrations of raw microbubbles via MR, an alternative detection scheme must be used.
HyperCEST is an NMR technique capable of indirectly detecting signals from very dilute molecules that exchange hyperpolarized 129Xe and that are present at concentrations that fall well below the NMR detection threshold. Here, we use quantitative hyperCEST to show that microbubbles are very efficient hyperCEST agents. They can accommodate and saturate millions of 129Xe atoms at a time, allowing for their indirect detection at concentrations as low as 10 femtomolar. The increased MR sensitivity to microbubbles achieved via hyperCEST can bridge the gap for microbubbles to become a dual modality contrast agent.
The Flux Qubit Revisited to Enhance Coherence and Reproducibility
Creators: name: Yan, F.
name: Gustavsson, S.
name: Kamal, A.
name: Birenbaum, J.
name: Sears, A. P.
name: Hover, D.
name: Rosenberg, D.
name: Samach, G.
name: Gudmundsen, T. J.
name: Yoder, J. L.
name: Orlando, T. P.
name: Clarke, J.
name: Kerman, A. J.
name: Oliver, W. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The scalable application of quantum information science will stand on reproducible and controllable high-coherence quantum bits (qubits). Here, we revisit the design and fabrication of the superconducting flux qubit, achieving a planar device with broad frequency tunability, strong anharmonicity, high reproducibility, and relaxation times in excess of $40\,μ$s at its flux-insensitive point. Qubit relaxation times $T_1$ across 22 qubits are consistently matched with a single model involving resonator loss, ohmic charge noise, and 1/f flux noise, a noise source previously considered primarily in the context of dephasing. We furthermore demonstrate that qubit dephasing at the flux-insensitive point is dominated by residual thermal photons in the readout resonator. The resulting photon shot noise is mitigated using a dynamical decoupling protocol, resulting in $T_2\approx 85\,μ$s, approximately the $2T_1$ limit. In addition to realizing an improved flux qubit, our results uniquely identify photon shot noise as limiting $T_2$ in contemporary qubits based on transverse qubit-resonator interaction.
From particle counting to Gaussian tomography
Creators: name: Parthasarathy, K. R.
name: Sengupta, Ritabrata
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Functional Analysis (math.FA)
subject: Statistics Theory (math.ST)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: All the $n(2n+3)$ mean and covariance parameters of an $n$-mode Gaussian states are expressed in terms of the expectation values of the same number of conjugates of the total number observable. This permits a complete tomography of the state. The same is applied to outputs of a Gaussian channel corresponding to selected coherent states to perform the complete tomography of the channel. This leads to some interesting problems concerning the distribution of the number operator and also tomographic complexity.
(4258) Philip Jones
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
COVID-19 and emerging viral infections: The case for interferon lambda
Creators: name: Prokunina-Olsson, L.
name: Kotenko, S.V.
name: Santer, D.M.
name: Onabajo, O.O.
name: Durbin, J.E.
name: Lazear, H.M.
name: Glenn, J.S.
name: Wack, A.
name: Reich, N.C.
name: Piontkivska, H.
name: Hartmann, R.
name: Zanoni, I.
name: Dickenson, R.E.
name: Alphonse, N.
name: Odendall, C.
name: O'Brien, T.R.
Publisher: name: Rockefeller University Press
Year: 2020

description: With the first reports on coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the scientific community working in the field of type III IFNs (IFN-λ) realized that this class of IFNs could play an important role in this and other emerging viral infections. In this Viewpoint, we present our opinion on the benefits and potential limitations of using IFN-λ to prevent, limit, and treat these dangerous viral infections.
Painel Competitivo EPQ -- Código de Ética da Anpad - Open Data na Área de Negócios: A Experiência Inédita da RAC
Creators: name: Mendes-Da-Silva, W.
Publisher: name: Zenodo
Year: 2020
Subjects: Ethics
Open Data
Open Science

description: This presentation is related to a roundtable during EnAnpad 2020.
MPEC 2023-Q145 : 2023 QR6
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 QR6

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
(4260) Mary Rachel Jones
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
High-Q Optical Cavities in Hyperuniform Disordered Materials
Creators: name: Amoah, Timothy
name: Florescu, Marian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce the first designs for high-Q photonic cavities in slab architectures in hyperuniform disordered solids displaying isotropic band gaps. Despite their disordered character, hyperuniform disordered structures have the ability to tightly confine the TE-polarised radiation in slab configurations that are readily fabricable. The architectures are based on carefully designed local modifications of otherwise unperturbed hyperuniform dielectric structures. We identify a wide range of confined cavity modes, which can be classified according to their approximate symmetry (monopole, dipole, quadrupole, etc.) of the confined electromagnetic wave pattern. We demonstrate that quality factors ($Q$) $Q>10^{9}$ can be achieved for purely 2D structures, and that for three--dimensional finite-height photonic slabs, quality factors $Q>20,000$ can be maintained.
Flavivirus envelope protein glycosylation: Impacts on viral infection and pathogenesis
Creators: name: Carbaugh, D.L.
name: Lazear, H.M.
Publisher: name: American Society for Microbiology
Year: 2020

description: Flaviviruses encode one, two, or no N-linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication. Envelope protein glycosylation has been identified as a virulence determinant for multiple flaviviruses, but the mechanisms by which glycosylation mediates pathogenesis remain unclear. In this Gem, we summarize current knowledge on flavivirus envelope protein glycosylation and its impact on viral infection and pathogenesis.
(4256) Philip Henry Wicksteed
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection
Creators: name: Holley, C.L.
name: Lazear, H.M.
name: McIntyre, A.B.R.
name: Gokhale, N.S.
name: Mattocks, M.D.
name: Mason, C.E.
name: Horner, S.M.
Publisher: name: Cell Press
Year: 2020

description: The RNA modification N6-methyladenosine (m6A) modulates mRNA fate and thus affects many biological processes. We analyzed m6A across the transcriptome following infection by dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), and hepatitis C virus (HCV). We found that infection by these viruses in the Flaviviridae family alters m6A modification of specific cellular transcripts, including RIOK3 and CIRBP. During viral infection, the addition of m6A to RIOK3 promotes its translation, while loss of m6A in CIRBP promotes alternative splicing. Importantly, viral activation of innate immune sensing or the endoplasmic reticulum (ER) stress response contributes to the changes in m6A in RIOK3 or CIRBP, respectively. Further, several transcripts with infection-altered m6A profiles, including RIOK3 and CIRBP, encode proteins that influence DENV, ZIKV, and HCV infection. Overall, this work reveals that cellular signaling pathways activated during viral infection lead to alterations in m6A modification of host mRNAs to regulate infection. Here, Gokhale, McIntyre et al. identify m6A changes in cellular mRNAs following Flaviviridae infection and demonstrate that infection-activated pathways contribute to these changes. They show that altered m6A modification in RIOK3 and CIRBP mRNAs influence their translation and splicing, respectively, and that RIOK3, CIRBP, and other m6A-altered factors regulate infection.
Formulation of spinors in terms of gauge fields
Creators: name: Vatsya, Shiv R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: It is shown in the present paper that the transformation relating a parallel transported vector in a Weyl space to the original one is the product of a multiplicative gauge transformation and a proper orthochronous Lorentz transformation. Such a Lorentz transformation admits a spinor representation, which is obtained and used to deduce the transportation properties of a Weyl spinor, which are then expressed in terms of a composite gauge group defined as the product of a multiplicative gauge group and the spinor group. These properties render a spinor amenable to its treatment as a particle coupled to a multidimensional gauge field in the framework of the Kaluza-Klein formulation extended to multidimensional gauge fields. In this framework, a fiber bundle is constructed with a horizontal, base space and a vertical, gauge space, which is a Lie group manifold, termed its structure group. For the present, the base is the Minkowski spacetime and the vertical space is the composite gauge group mentioned above. The fiber bundle is equipped with a Riemannian structure, which is used to obtain the classical description of motion of a spinor. In its classical picture, a Weyl spinor is found to behave as a spinning charged particle in translational motion. The corresponding quantum description is deduced from the Klein-Gordon equation in the Riemann spaces obtained by the methods of path-integration. This equation in the present fiber bundle reduces to the equation for a spinor in the Weyl geometry, which is close to but differs somewhat from the squared Dirac equation.
description: 19 pages
On metrics of curvature 1 with four conic singularities on tori and on the sphere
Creators: name: Eremenko, Alexandre
name: Gabrielov, Andrei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Analysis of PDEs (math.AP)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 34M03, 34M05, 35J91, 33E05

description: We discuss conformal metrics of curvature 1 on tori and on the sphere, with four conic singularities whose angles are multiples of pi/2. Besides some general results we study in detail the family of such symmetric metrics on the sphere, with angles (pi/2,3pi/2,pi/2,3pi/2).
description: 25 pages, 5 figures
Enhancing Education through Experience: Designing an Experiential Learning Curriculum for Holistic Development
Creators: name: Aneke,, Marcellinus N., Ph. D
name: Omemgboji,, Irene Adaora
Publisher: name: GO JOURNAL
Year: 2024
Subjects: Experiential learning, transformative approach, models

description: This paper explores the concept of experiential learning as a transformative approach to education, emphasizing its potential to enhance holistic development among learners. The definition of experiential learning and its main tenets active participation, reflection, and application are covered in the first section of the study. The advantages of experience learning are then covered, including enhanced retention, deeper comprehension, and the growth of critical thinking and problem-solving abilities. The development and application of an experiential learning curriculum is the main purpose of this paper. It describes the fundamental components of such a curriculum, such as defining learning goals, choosing relevant experiences, and incorporating systems for reflection and assessment. The study also examines other frameworks and models, such as Kolb's Experiential Learning Theory and Dewey's concept of reflective thinking that can direct the creation of an experiential learning curriculum. The impact of experiential learning on cognitive, social, emotional, and physical components of development is also examined in this research. It emphasizes the value of experiential learning in developing the kinds of abilities and proficiencies that are essential for success in the twenty-first century, like resilience, adaptability, and teamwork. In conclusion, the paper recommends that designing an experiential learning curriculum can significantly enhance education by providing students with meaningful and transformative learning experiences. It emphasizes the need for educators to embrace experiential learning as a powerful tool for fostering holistic development and preparing students for the challenges of an ever-changing world.
IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection
Creators: name: Handfield, C.
name: Floyd, L.
name: Sempowski, G.
name: Sarkar, M.K.
name: Horner, S.M.
name: MacLeod, A.S.
name: Suwanpradid, J.
name: Shannon, J.
name: Uppala, R.
name: Hoang, P.
name: Labagnara, K.F.
name: Kwock, J.T.
name: Lazear, H.M.
name: Gudjonsson, J.E.
name: McFadden, M.J.
name: Corcoran, D.L.
Publisher: name: American Association for the Advancement of Science
Year: 2020

description: In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense. Here, we identify and characterize the induction of cutaneous innate antiviral proteins in response to IL-27 and its functional role during cutaneous defense against Zika virus infection. Transcriptional and phenotypic profiling of epidermal keratinocytes treated with IL-27 demonstrated activation of antiviral proteins OAS1, OAS2, OASL, and MX1 in the skin of both mice and humans. IL-27–mediated antiviral protein induction was found to occur in a STAT1- and IRF3-dependent but STAT2-independent manner. Moreover, using IL27ra mice, we demonstrate a significant role for IL-27 in inhibiting Zika virus morbidity and mortality following cutaneous, but not intravenous, inoculation. Together, our results demonstrate a critical and previously unrecognized role for IL-27 in cutaneous innate antiviral immunity against Zika virus.
(4248) George Edward Watson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Protective and Pathogenic Effects of Interferon Signaling during Pregnancy
Creators: name: Casazza, R.L.
name: Lazear, H.M.
name: Miner, J.J.
Publisher: name: Mary Ann Liebert Inc.
Year: 2020

description: Immune regulation at the maternal-fetal interface is complex due to conflicting immunological objectives: protection of the fetus from maternal pathogens and prevention of immune-mediated rejection of the semiallogeneic fetus and placenta. Interferon (IFN) signaling plays an important role in restricting congenital infections as well as in the physiology of healthy pregnancies. In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during healthy pregnancy. Finally, we review mechanisms by which dysregulated type I IFN responses contribute to poor pregnancy outcomes in humans with autoimmune disease, including interferonopathies and systemic lupus erythematosus.
On Parisian ruin over a finite-time horizon
Creators: name: Debicki, Krzysztof
name: Hashorva, Enkelejd
name: Ji, Lanpeng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G15, 60G70

description: For a risk process $R_u(t)=u+ct-X(t), t\ge 0$, where $u\ge 0$ is the initial capital, $c>0$ is the premium rate and $X(t),t\ge 0$ is an aggregate claim process, we investigate the probability of the Parisian ruin \[ \mathcal{P}_S(u,T_u)=\mathbb{P}\{\inf_{t\in[0,S]} \sup_{s\in[t,t+T_u]} R_u(s)<0\}, \] with a given positive constant $S$ and a positive measurable function $T_u$. We derive asymptotic expansion of $\mathcal{P}_S(u,T_u)$, as $u\to\infty$, for the aggregate claim process $X$ modeled by Gaussian processes. As a by-product, we derive the exact tail asymptotics of the infimum of a standard Brownian motion with drift over a finite-time interval.
description: 20
Excited-state hydroxyl maser polarimetry: Who ate all the πs?
Creators: name: Green, James A
name: Caswell, James L
name: McClure-Griffiths, Naomi M
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present polarimetric maser observations with the Australia Telescope Compact Array (ATCA) of excited-state hydroxyl (OH) masers. We observed 30 fields of OH masers in full Stokes polarization with the Compact Array Broadband Backend (CABB) at both the 6030 and 6035 MHz excited-state OH transitions, and the 6668-MHz methanol maser transition, detecting 70 sites of maser emission. Amongst the OH we found 112 Zeeman pairs, of which 18 exhibited candidate π components. This is the largest single full polarimetric study of multiple sites of star formation for these frequencies, and the rate of 16% π components clearly indicates the π component exists, and is comparable to the percentage recently found for ground-state transitions. This significant percentage of π components, with consistent proportions at both ground- and excited-state transitions, argues against Faraday rotation suppressing the π component emission. Our simultaneous observations of methanol found the expected low level of polarisation, with no circular detected, and linear only found at the less than or equal to 10% level for the brightest sources.
description: 17 pages (72 pages including appendices), 9 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society
LEKSIK SINONIMLARNING MA'NO XUSUSIYATLARI (ABDULLA ORIPOV SHE'RIYATI MISOLIDA)
Creators: name: Ro'ziyeva, Xurshida
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada leksik sinonimlarning alohidalik kasb etgan ma’no qirralari xususida so‘z boradi, shuningdek, sinonimik qatorlarda dominantaning o‘rni va ahamiyatiga e’tibor qaratilgan hamda Abdulla Oripov she’riyati misolida tahlil qilingan.
Shared and Distinct Functions of Type I and Type III Interferons
Creators: name: Diamond, M.S.
name: Lazear, H.M.
name: Schoggins, J.W.
Publisher: name: Cell Press
Year: 2019

description: Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences. Here, we provide a comprehensive review of type I and type III IFN activities, highlighting shared and distinct features from molecular mechanisms through physiological responses. Beyond discussing canonical antiviral functions, we consider the adaptive immune priming, anti-tumor, and autoimmune functions of IFNs. We discuss a model wherein type III IFNs serve as a front-line defense that controls infection at epithelial barriers while minimizing damaging inflammatory responses, reserving the more potent type I IFN response for when local responses are insufficient. In this context, we discuss current therapeutic applications targeting these cytokine pathways and highlight gaps in understanding of the biology of type I and type III IFNs in health and disease.
Dynamics of many-body localisation in a translation invariant quantum glass model
Creators: name: van Horssen, Merlijn
name: Levi, Emanuele
name: Garrahan, Juan P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the real-time dynamics of a translationally invariant quantum spin chain, based on the East kinetically constrained glass model, in search for evidence of many-body localisation in the absence of disorder. Numerical simulations indicate a change, controlled by a coupling parameter, from a regime of fast relaxation---corresponding to thermalisation---to a regime of very slow relaxation. This slowly relaxing regime is characterised by dynamical features usually associated with non-ergodicity and many-body localisation (MBL): memory of initial conditions, logarithmic growth of entanglement entropy, and non-exponential decay of time-correlators. We show that slow relaxation is a consequence of sensitivity to spatial fluctuations in the initial state. While numerics indicate that certain relaxation timescales grow markedly with size, our finite size results are consistent both with an MBL transition, expected to only occur in disordered systems, or with a pronounced quasi-MBL crossover.
description: 5 pages, 4 figures
(4254) Sigurd Taylor Wicksteed
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Theoretical investigation on the transition metal borides with Ta3B4-type structure: a class of hard and refractory materials
Creators: name: Miao, Naihua
name: Sa, Baisheng
name: Zhou, Jian
name: Sun, Zhimei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Based on density functional theory, we have systematically studied the structural stability, mechanical properties and chemical bonding of the transition metal borides M3B4 (M=Ti, V, Cr, Zr, Nb, Mo, Hf, Ta, and W) for the first time. All the present studied M3B4 have been demonstrated to be thermodynamically and mechanically stable. The bulk modulus, shear modulus, Young's modulus, Poisson's ratio, microhardness, Debye temperature and anisotropy have been derived for ideal polycrystalline M3B4 aggregates. In addition, the relationship between Debye temperature and microhardness has been discussed for these isostructral M3B4. Furthermore, the results of the Cauchy pressure, the ratio of bulk modulus to shear modulus, and Poisson's ratio suggest that the valence electrons of transition metals play an important role in the ductility of M3B4. The calculated total density of states for M3B4 indicates that all these borides display a metallic conductivity. By analyzing the electron localization function, we show that the improvement of the ductility in these M3B4 might attribute to the decrease of their angular bonding character.
Why Is IFN-λ Less Inflammatory? One IRF Decides
Creators: name: Casazza, R.L.
name: Lazear, H.M.
Publisher: name: Cell Press
Year: 2019

description: Type I and type III interferons (IFNs) activate similar antiviral transcriptional programs, but the type I IFN response is more inflammatory. In this issue of Immunity, Forero et al. find that selective induction of the transcription factor IRF1 promotes proinflammatory chemokine expression downstream of type I IFN signaling.
Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy
Creators: name: Permar, S.R.
name: De Vargas, P.R.M.
name: Itell, H.L.
name: Hall, A.
name: Roark, H.K.
name: Giuberti, C.
name: Webster, H.S.
name: Dietze, R.
name: Dennis, M.L.
name: Corey, R.G.
name: Lazear, H.M.
name: Lopez, C.A.
name: Singh, T.
name: Heimsath, H.J.
name: Swamy, G.K.
Publisher: name: Public Library of Science
Year: 2019

description: Zika virus (ZIKV) is a newly-identified infectious cause of congenital disease. Transplacental transfer of maternal IgG to the fetus plays an important role in preventing many neonatal infections. However, antibody transfer may also have negative consequences, such as mediating enhancement of flavivirus infections in early life, or trafficking of virus immune complexes to the fetal compartment. ZIKV infection produces placental pathology which could lead to impaired IgG transfer efficiency as occurs in other maternal infections, such as HIV-1 and malaria. In this study, we asked whether ZIKV infection during pregnancy impairs transplacental transfer of IgG. We enrolled pregnant women with fever or rash in a prospective cohort in Vitoria, Brazil during the recent ZIKV epidemic. ZIKV and dengue virus (DENV)-specific IgG, ZIKV and DENV neutralizing antibodies, and routine vaccine antigenspecific IgG were measured in maternal samples collected around delivery and 20 paired cord blood samples. We concluded that 8 of these mothers were infected with ZIKV during pregnancy and 12 were ZIKV-uninfected. The magnitude of flavivirus-specific IgG, neutralizing antibody, and vaccine-elicited IgG were highly correlated between maternal plasma and infant cord blood in both ZIKV-infected and -uninfected mother-infant pairs. Moreover, there was no difference in the magnitude of plasma flavivirus-specific IgG levels between mothers and infants regardless of ZIKV infection status. Our data suggests that maternal ZIKV infection during pregnancy does not impair the efficiency of placental transfer of flavivirus-specific, functional, and vaccine-elicited IgG. These findings have implications for the neonatal outomes of maternal ZIKV infection and optimal administration of antibody-based ZIKV vaccines and therapeutics.
Mapping the suggestion of a food social security
Creators: name: Tsilla Boisselet
Publisher: name: Zenodo
Year: 2020
Subjects: wardleymapping; food system social security, resilience

description: Mapping the suggestion of a food social security: “a farmer could have, socially seen, the status of a town doctor" . An exercise on the why such suggestion, sustained by AMAP, Confédération paysanne, Ingénieurs sans frontière Agrista , Réseau Salariat makes sense for sustainability. Mapping poses a clear base for discussion about this principles, making visible some emerging questions. Changing the way food is produced requires high and broad involvement, mapping helps grasping its complexity without getting overwhelmed, and shows the usefulness of increasing chosen partnerships and links in innovative ways.
Follow My Recommendations: A Personalized Privacy Assistant for Mobile App Permissions
Creators: name: Liu, Bin
name: Andersen, Mads Schaarup
name: Schaub, Florian
name: Almuhimedi, Hazim
name: Shikun Zhang
name: Sadeh-Koniecpol, Norman
name: Acquisti, Alessandro
name: Yuvraj Agarwal
Publisher: name: Carnegie Mellon University
Year: 2020
Subjects: subject: 80602 Computer-Human Interaction
subject: FOS: Psychology

description: Modern smartphone platforms have millions of apps, many of which request permissions to access private data and resources, like user accounts or location. While these smartphone platforms provide varying degrees of control over these permissions, the sheer number of decisions that users are expected to manage has been shown to be unrealistically high. Prior research has shown that users are often unaware of, if not uncomfortable with, many of their permission settings. Prior work also suggests that it is theoretically possible to predict many of the privacy settings a user would want by asking the user a small number of questions. However, this approach has neither been operationalized nor evaluated with actual users before. We report on a field study (n=72) in which we implemented and evaluated a Personalized Privacy Assistant (PPA) with participants using their own Android devices. The results of our study are encouraging. We find that 78.7% of the recommendations made by the PPA were adopted by users. Following initial recommendations on permission settings, participants were motivated to further review and modify their settings with daily “privacy nudges.” Despite showing substantial engagement with these nudges, participants only changed 5.1% of the settings previously adopted based on the PPA's recommendations. The PPA and its recommendations were perceived as useful and usable. We discuss the implications of our results for mobile permission management and the design of personalized privacy assistant solutions
Presented at the 12th Symposium on Usable Privacy and Security (SOUPS) 2016, June 22–24, 2016, Denver, Colorado.
(4255) Ellen Maria Wicksteed
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.