cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The strong effect of electron thermal conduction on the global structure of the heliosphere
Creators: name: Izmodenov, V. V.
name: Alexashov, D. B.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Voyager 1 and 2 crossed the heliopause at $\sim$122 AU in 2012 and $\sim$119 AU in 2018, respectively. It was quite a surprise because the thickness of the inner heliosheath obtained by the existing at that time models of the global heliosphere was significantly larger (by 20-40 AU). Until now, the problem of the heliosheath thickness has not been fully resolved. Earlier in the frame of an oversimplified toy model of nearly isothermal solar wind plasma it has been shown that the effect of electron thermal conduction may significantly reduce the thickness of the inner heliosheath. In this paper, we present the first results of our 3D kinetic-MHD model of the global heliosphere, where the effect of thermal electron conduction has been considered rigorously. The thermal conduction acts mainly along the magnetic field lines. Classical and saturated thermal fluxes are employed when appropriate. It is shown the effects of thermal conduction are significant. The thickness of the inner heliospheric is reduced. It is desired effect since it helps to reconcile the thickness obtained in the model with Voyager data. The other effects are the strong depletion of the heliosheath plasma temperature toward the heliopause and the increase of the plasma temperature in the supersonic solar wind upstream of the termination shock.
description: 7 pages, 5 figures, accepted for publication in MNRAS
Conservation of angular momentum and the existence of absolute time and space
Creators: name: Paglietti, A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: The law of balance of angular momentum is shown to imply the existence of absolute time, a fundamental physical quantity that is independent of the motion or position of the observer. Absolute time implies the notion of absolute simultaneity, which in turn leads to the notion of absolute distance between two points. The existence of absolute space follows as a consequence. These concepts apply to every field of physics to which the angular momentum balance law applies, and in particular to the theory of special relativity. The paper also shows that in a vacuum, the independence of the speed of light from the motion of its source makes it possible to determine the absolute positions of all points in space. The same independence also allows us to determine the state of absolute rest or motion of a reference frame from within the frame itself.
description: Original version of a paper to be publisnhed in Physics Essays 36 (1), 100-107 (2023)
MEASURES TO ENSURE THE RELIABILITY OF WATER SUPPLY IN THE MLDB SYSTEM USING REFRIGERATION
Creators: name: Ramanpreet Kaur
name: Upasana Sharma
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: MLDB
MTSF
availability
semi-Markov process
regenerating point technique

description: Various components work together to form a system’s overall structure. Last but not least, how well each component functions affects how the system functions. Both a functioning and failing state are possible for a system built from components. Failure has a big effect on the way systems work in industry. So, in order to enhance system performance, it is essential to get rid of these errors. The aim of this research is to assess the scope of water supply concerns in the MLDB (Multi-Level Die Block) system at the Piston Foundry Plant.The MLDB system, which consists of a robotic key unit that works with the water supply, is the subject of this research. Robotic failure and a lack of water supply cause the system to fail.A reliability model is created in order to calculate MTSF (mean time to system failure), availability, busy times for repair, and profit evaluation. The abovementioned measurements were computed numerically and graphically using semi-Markov processes and the regenerating point technique. The results of this study are novel since no previous research has concentrated on the critical function of water delivery in the MLDB system in piston foundries. According to the discussion, the findings are both highly exciting and beneficial for piston manufacturing businesses who use the MLDB system. For companies that make pistons and use the MLDB system, the conclusions, according to the debate, are particularly beneficial.
Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
Creators: name: Leranth, Csaba
name: Vives, Kenneth P
name: Bober, Jeremy
name: Leichtle, Stefan
name: Redmond, D Eugene
name: Elsworth, John D
name: Markakis, Eleni A
name: Roth, Robert H
name: Samulski, R Jude
name: Beecham, Jeff
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Vectors derived from adeno-associated virus (AAV) are promising candidates for neural cell transduction in vivo because they are nonpathogenic and achieve long-term transduction in the central nervous system. AAV serotype 2 (AAV2) is the most widely used AAV vector in clinical trials based largely on its ability to transduce neural cells in the rodent and primate brain. Prior work in rodents suggests that other serotypes might be more efficient; however, a systematic evaluation of vector transduction efficiency has not yet been performed in the primate brain. In this study, AAV viral vectors of serotypes 1–6 with an enhanced green-fluorescent protein (GFP) reporter gene were generated at comparable titers, and injected in equal amounts into the brains of Chlorocebus sabaeus. Vector injections were placed in the substantia nigra (SN) and the caudate nucleus (CD). One month after injection, immunohistochemistry for GFP was performed and the total number of GFP+ cells was calculated using unbiased stereology. AAV5 was the most efficient vector, not only transducing significantly more cells than any other serotype, but also transducing both NeuN+ and glial-fibrillary-acidic protein positive (GFAP+) cells. These results suggest that AAV5 is a more effective vector than AAV2 at delivering potentially therapeutic transgenes to the nigrostriatal system of the primate brain.
Empirical studies on the network of social groups: the case of Tencent QQ
Creators: name: You, Zhi-Qiang
name: Han, Xiao-Pu
name: Lü, Linyuan
name: Yeung, Chi Ho
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Participation in social groups are important but the collective behaviors of human as a group are difficult to analyze due to the difficulties to quantify ordinary social relation, group membership, and to collect a comprehensive dataset. Such difficulties can be circumvented by analyzing online social networks. In this paper, we analyze a comprehensive dataset obtained from Tencent QQ, an instant messenger with the highest market share in China. Specifically, we analyze three derivative networks involving groups and their members -- the hypergraph of groups, the network of groups and the user network -- to reveal social interactions at microscopic and mesoscopic level. Our results uncover interesting behaviors on the growth of user groups, the interactions between groups, and their relationship with member age and gender. These findings lead to insights which are difficult to obtain in ordinary social networks.
description: 18 pages, 9 figures
Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)
Creators: name: Samulski, R Jude
name: McCown, Thomas J
name: Blake, Bonita L
name: Nicolson, Sarah C
name: Criswell, Hugh E
name: Gray, Steven J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: DNA shuffling and directed evolution were employed to develop a novel adeno-associated virus (AAV) vector capable of crossing the seizure-compromised blood–brain barrier (BBB) and transducing cells in the brain. Capsid DNA from AAV serotypes 1–6, 8, and 9 were shuffled and recombined to create a library of chimeric AAVs. One day after kainic acid–induced limbic seizure activity in rats, the virus library was infused intravenously (i.v.), and 3 days later, neuron-rich cells were mechanically dissociated from seizure-sensitive brain sites, collected and viral DNA extracted. After three cycles of selection, green fluorescent protein (GFP)–packaged clones were administered directly into brain or i.v. 1 day after kainic acid–induced seizures. Several clones that were effective after intracranial administration did not transduce brain cells after the i.v. administration. However, two clones (32 and 83) transduced the cells after direct brain infusion and after i.v. administration transduced the cells that were localized to the piriform cortex and ventral hippocampus, areas exhibiting a seizure-compromised BBB. No transduction occurred in areas devoid of BBB compromise. Only one parental serotype (AAV8) exhibited a similar expression profile, but the biodistribution of 32 and 83 diverged dramatically from this parental serotype. Thus, novel AAV vectors have been created that can selectively cross the seizure-compromised BBB and transduce cells.
Pathways to net zero for power and industry in the United Kingdom
Creators: name: Ganzer, Caroline
Publisher: name: Imperial College London
Year: 2022

description: Climate change mitigation is amongst the key challenges of the Anthropocene. The United Kingdom has declared its interest in leading the way to net zero CO2 emissions by 2050. The debate around technologically feasible, economically viable, and socially optimal pathways to a carbon neutral energy system and economy is ongoing. This thesis aims to contribute to questions concerning the decarbonisation of power and industry in the UK. To this end, the technological viewpoint, the system viewpoint, and public viewpoint are assumed. First, electrification of heat and transport is quantified, and the role and value of power-to-gas storage as novel technology is analysed. Second, the industrial sector is modelled, and pathways for the combined decarbonisation of power and industry are investigated. Third, trajectories to net zero are connected to economic growth and employment, bridging the gap between technology-focused energy systems modelling and the macroeconomic layer. It is found that seasonal effects are significant in the energy system under electrification and increasing deployment levels of intermittent renewable energy. Inter-seasonal storage and/or low-carbon dispatchable power generation are required to ensure a reliable supply of electricity. Cost-optimal abatement technologies in industry are identified. The emissions balance between the power and industrial sectors is evaluated, with power reaching carbon negativity in the 2040s, and offsetting residual emissions in industry in 2050. Carbon capture and sequestration emerges as key technology in trajectories to net zero. The effects of policy instruments, including a carbon price and negative emissions credit, are quantified, and the importance of a compromise between private and public sector is highlighted. Further, a net zero target is estimated to increase value added and employment. Importing industrial goods and offshoring emissions vs. expanding domestic production and exporting low-carbon products, as well as locally sourcing vs. importing technology components and raw materials are shown to greatly impact value and job creation.
Expression of Dog Microdystrophin in Mouse and Dog Muscles by Gene Therapy
Creators: name: Cerri, Daniel G
name: Bizario, João CS
name: Kornegay, Joe N
name: Xiao, Xiao
name: Chapdelaine, Pierre
name: Quenneville, Simon P
name: Dominique, Jean-Christophe
name: Skuk, Daniel
name: Pichavant, Christophe
name: Tremblay, Jacques P
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Duchenne muscular dystrophy (DMD) is characterized by the absence of dystrophin. Several previous studies demonstrated the feasibility of delivering microdystrophin complementary DNA (cDNA) into mouse and normal nonhuman primate muscles by ex vivo gene therapy. However, these animal models do not reproduce completely the human DMD phenotype, while the dystrophic dog model does. To progress toward the use of the best animal model of DMD, a dog microdystrophin was transduced into human and dystrophic dog muscle precursor cells (MPCs) with a lentivirus before their transplantation into mouse muscles. One month following MPC transplantation, myofibers expressing the dog microdystrophin were observed. We also used another approach to introduce this transgene into myofibers, i.e., the electrotransfer of a plasmid coding for the dog microdystrophin. The plasmid was injected into mouse and dog muscles, and brief electric pulses were applied in the region of injection. Two weeks later, the transgene was detected in both animals. Therefore, ex vivo gene therapy and electrotransfer are two possible methods to introduce a truncated version of dystrophin into myofibers of animal models and eventually into myofibers of DMD patients.
OPTIMAL ECONOMIC AGE REPLACEMENT MODELS FOR NON-REPAIRABLE SYSTEMS WITH SUDDEN BUT NON-CONSTANT FAILURE RATE
Creators: name: Nse Udoh
name: Iniobong Uko
name: Akaninyene Udom
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Birnbaum-Saunders distribution
Radio Transmitter Systems
Reliability
Replacement model
Availability
Optimum replacement time and cost

description: Proper maintenance of non-repairable systems is essential for optimum utilization of systems to prevent lost production runs, cost inefficiencies, defective output which leads to customer dissatisfaction and unavailability of the facility for future use. This work proposes new preventive replacement maintenance models with constant-interval preventive replacement time with associated cost of replacement maintenance. Improved results of economic values with respect to optimal replacement time at minimum cost were obtained for radio transmitter system with sudden but non-constant failure rate when compared to some existing models. Other parameters and maintenance probabilities of the system were also obtained including; reliability, hazard rate and availability to ascertain the operational condition of the system.
Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B
Creators: name: Ehrhardt, Anja
name: Nichols, Timothy C
name: Merricks, Elizabeth P
name: Franck, Helen G
name: Kay, Mark A
name: Hausl, Martin A
name: Müther, Nadine
name: Zhang, Wenli
name: Rauschhuber, Christina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Sleeping Beauty (SB) transposase enables somatic integration of exogenous DNA in mammalian cells, but potency as a gene transfer vector especially in large mammals has been lacking. Herein, we show that hyperactive transposase system delivered by high-capacity adenoviral vectors (HC-AdVs) can result in somatic integration of a canine factor IX (cFIX) expression-cassette in canine liver, facilitating stabilized transgene expression and persistent haemostatic correction of canine hemophilia B with negligible toxicity. We observed stabilized cFIX expression levels during rapid cell cycling in mice and phenotypic correction of the bleeding diathesis in hemophilia B dogs for up to 960 days. In contrast, systemic administration of an inactive transposase system resulted in rapid loss of transgene expression and transient phenotypic correction. Notably, in dogs a higher viral dose of the active SB transposase system resulted into transient phenotypic correction accompanied by transient increase of liver enzymes. Molecular analysis of liver samples revealed SB-mediated integration and provide evidence that transgene expression was derived mainly from integrated vector forms. Demonstrating that a viral vector system can deliver clinically relevant levels of a therapeutic protein in a large animal model of human disease paves a new path toward the possible cure of genetic diseases.
Material and structural behaviour of metal 3D printed elements
Creators: name: Huang, Cheng
Publisher: name: Imperial College London
Year: 2022

description: Wire arc additive manufacturing (WAAM) is a metal 3D printing method that enables large-scale structural elements with complex geometry to be built in a relatively efficient and cost-effective manner, offering revolutionary potential to the construction industry. Fundamental experimental data on the material and structural behaviour of WAAM elements are however lacking. Therefore, a comprehensive experimental study into the material properties, the cross-section and the member buckling behaviour of WAAM elements has been conducted and is reported herein. Tensile tests on 137 WAAM steel coupons, covering different steel grades, finishes, thicknesses, extraction directions and locations, and deposition strategies, have been conducted. Microstructural characterisation has also been performed by means of optical microscopy (OM) and electron backscatter diffraction (EBSD). At the cross-section and member levels, four-point bending tests on 14 WAAM stainless steel tubular beams and flexural buckling tests on 18 WAAM stainless steel tubular columns have been undertaken, respectively. Owing to the geometric undulations inherent to the WAAM process, 3D laser scanning and digital image correlation (DIC) were employed in the material, beam and column testing programme to capture the geometric properties and deformation responses of the specimens, respectively. The present research focuses on WAAM elements subjected to predominantly static loading (rather than fatigue loading), with an emphasis on structural stability. The examined WAAM steels exhibited consistent, almost isotropic mechanical properties, a Young’s modulus comparable to conventionally-produced steel plates, marginally lower strength, reflecting the slower cooling conditions than is customary, and good ductility. To describe the full stress-strain response of WAAM steels, material models were proposed and validated against the tensile test results and further experimental data collected from the literature. Following the beam and column tests, the applicability of the current cross-section and column design provisions in EN 1993-1-4 and AISC 370, as well as the continuous strength method (CSM), to WAAM stainless steel elements was assessed by comparing the test results with the strength predictions. The comparisons highlighted the need to allow for the weakening effect of the inherent geometric undulations of WAAM elements, in order to achieve safe-sided strength predictions.
Calibration procedure for testing machines to extend the traceability chain from static to continuous forces which can be used for forces in the range of 1 N to 1 MN
Creators: name: Knott, Andy
name: Sander, Jonas
name: Kumme, Rolf
name: Tegtmeier, Falk
name: Hiti, Miha
name: Vavrečka, Lukáš
name: Fidelus, Janusz
name: Prato, Andrea
name: Germak, Alex
name: Dizdar, Haldun
name: Aydemir, Bulent
name: Korhonen, Jani
name: Oliveira, Rafael Soares
Publisher: name: Zenodo
Year: 2023
Subjects: calibration procedure
traceability chain
continuous forces
static forces
uniaxial testing machine
creep test
synchronisation

description: The aim of this work was to develop a calibration procedure to cover the production of static and continuous
 forces by industrial machines, used for both materials testing and in the larger scale testing of components,
 products, and structures – this second application incorporated the use of multiple force sensors, reversal
 of loading direction, and novel transducer design.
description: The ComTraForce project 18SIB08 has received funding from the European Metrology Programme for Innovation and Research (EMPIR) as well as the European Association of National Metrology Institutes (Euramet).
Engineering spin-orbit coupling for photons and polaritons in microstructures
Creators: name: Sala, V. G.
name: Solnyshkov, D. D.
name: Carusotto, I.
name: Jacqmin, T.
name: Lemaître, A.
name: Terças, H.
name: Nalitov, A.
name: Abbarchi, M.
name: Galopin, E.
name: Sagnes, I.
name: Bloch, J.
name: Malpuech, G.
name: Amo, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: One of the most fundamental properties of electromagnetism and special relativity is the coupling between the spin of an electron and its orbital motion. This is at the origin of the fine structure in atoms, the spin Hall effect in semiconductors, and underlies many intriguing properties of topological insulators, in particular their chiral edge states. Configurations where neutral particles experience an effective spin-orbit coupling have been recently proposed and realized using ultracold atoms and photons. Here we use coupled micropillars etched out of a semiconductor microcavity to engineer a spin-orbit Hamiltonian for photons and polaritons in a microstructure. The coupling between the spin and orbital momentum arises from the polarisation dependent confinement and tunnelling of photons between micropillars arranged in the form of a hexagonal photonic molecule. Dramatic consequences of the spin-orbit coupling are experimentally observed in these structures in the wavefunction of polariton condensates, whose helical shape is directly visible in the spatially resolved polarisation patterns of the emitted light. The strong optical nonlinearity of polariton systems suggests exciting perspectives for using quantum fluids of polaritons11 for quantum simulation of the interplay between interactions and spin-orbit coupling.
description: main text: pages 1-11 (4 figures); supplementary material: pages 12-28 (9 figures)
Ecology versus taxonomy: is there a middle ground?
Creators: name: Nielsen, D. L
name: Shiel, R. J
name: Smith, F. J
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

In many long-term, intensive experimental and field studies there often arises a need to trade off taxonomic resolutionfor ecological answers. Compounding this problem is a taxonomic impediment, the lack of experiencedtaxonomists capable of processing large numbers of samples to species resolution, especially in groups such as theRotifera. This paper has two aims: (1) To investigate the level of taxonomic resolution required to determine theimpact of a disturbance, in the form of a flood event; (2) to compare the impact of different taxonomic resolutionsin assessing biodiversity. Results suggest both family and generic resolution can be used to determine the impactof a flood event and that these levels have some applicability to biodiversity studies. Relatively inexperiencedtaxonomists who can identify the common rotifers to generic level, can be relied upon to detect disturbance tocommunity structure but their data become unreliable when assessing biodiversity.
Testing the mutual consistency of different supernovae surveys
Creators: name: Karpenka, N. V.
name: Feroz, F.
name: Hobson, M. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: It is now common practice to constrain cosmological parameters using supernovae (SNe) catalogues constructed from several different surveys. Before performing such a joint analysis, however, one should check that parameter constraints derived from the individual SNe surveys that make up the catalogue are mutually consistent. We describe a statistically-robust mutual consistency test, which we calibrate using simulations, and apply it to each pairwise combination of the surveys making up, respectively, the UNION2 catalogue and the very recent JLA compilation by Betoule et al. We find no inconsistencies in the latter case, but conclusive evidence for inconsistency between some survey pairs in the UNION2 catalogue.
description: 8 pages, 9 figures, submitted to MNRAS
High-gain weakly nonlinear flux-modulated Josephson parametric amplifier using a SQUID-array
Creators: name: Zhou, X.
name: Schmitt, V.
name: Bertet, P.
name: Vion, D.
name: Wustmann, W.
name: Shumeiko, V.
name: Esteve, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have developed and measured a high-gain quantum-limited microwave parametric amplifier based on a superconducting lumped LC resonator with the inductor L including an array of 8 superconducting quantum interference devices (SQUIDs). This amplifier is parametrically pumped by modulating the flux threading the SQUIDs at twice the resonator frequency. Around 5 GHz, a maximum gain of 31 dB, a product amplitude-gain x bandwidth above 60 MHz, and a 1 dB compression point of -123 dBm at 20 dB gain are obtained in the non-degenerate mode of operation. Phase sensitive amplification-deamplification is also measured in the degenerate mode and yields a maximum gain of 37 dB. The compression point obtained is 18 dB above what would be obtained with a single SQUID of the same inductance, due to the smaller nonlinearity of the SQUID array.
description: 7 pages, 4 figures, 23 references
Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy
Creators: name: Huang, Leaf
name: Zhu, Xiaodong
name: Zhang, Xiaoju
name: Chen, Yunching
name: Liu, Bin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Targeted delivery of RNA-based therapeutics for cancer therapy remains a challenge. We have developed a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation modified with tumor-targeting single-chain antibody fragment (scFv) for systemic delivery of small interfering RNA (siRNA) and microRNA (miRNA) into experimental lung metastasis of murine B16F10 melanoma. The siRNAs delivered by the scFv targeted nanoparticles efficiently downregulated the target genes (c-Myc/MDM2/VEGF) in the lung metastasis. Two daily intravenous injections of the combined siRNAs in the GC4-targeted nanoparticles significantly reduced the tumor load in the lung. miRNA-34a (miR-34a) induced apoptosis, inhibited survivin expression, and downregulated MAPK pathway in B16F10 cells. miR-34a delivered by the GC4-targeted nanoparticles significantly downregulated the survivin expression in the metastatic tumor and reduced tumor load in the lung. When miR-34a and siRNAs were co-formulated in GC4-targeted nanoparticles, an enhanced anticancer effect was observed.
Assessing the spin-orbit obliquity of low-mass planets in the breaking the chain formation model: A story of misalignment
Creators: name: Esteves, Leandro
name: Izidoro, André
name: Winter, Othon C.
name: Bitsch, Bertram
name: Isella, Andrea
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences
subject: J.2
subject: 85-10

description: The spin-orbit obliquity of a planetary system constraints its formation history. A large obliquity may either indicate a primordial misalignment between the star and its gaseous disk or reflect the effect of different mechanisms tilting planetary systems after formation. Observations and statistical analysis suggest that system of planets with sizes between 1 and 4 R$_{\oplus}$ have a wide range of obliquities ($\sim0-30^{\circ}$), and that single- and multi-planet transiting have statistically indistinguishable obliquity distributions. Here, we revisit the ``breaking the chains'' formation model with focus in understanding the origin of spin-orbit obliquities. This model suggests that super-Earths and mini-Neptunes migrate close to their host stars via planet-disk gravitational interactions, forming chain of planets locked in mean-motion resonances. After gas-disk dispersal, about 90-99\% of these planetary systems experience dynamical instabilities, which spread the systems out. Using synthetic transit observations, we show that if planets are born in disks where the disk angular momentum is virtually aligned with the star's rotation spin, their final obliquity distributions peak at about $\sim$5 degrees or less, and the obliquity distributions of single and multi-planet transiting systems are statistically distinct. By treating the star-disk alignment as a free-parameter, we show that the obliquity distributions of single and multi-planet transiting systems only become statistically indistinguishable if planets are assumed to form in primordially misaligned natal disks with a ``tilt'' distribution peaking at $\gtrsim$10-20 deg. We discuss the origin of these misalignments in the context of star formation and potential implications of this scenario for formation models.
description: 11 pages, 9 figures, 2 tables. Accepted for publication in MNRAS
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Immagine ricorrente nel romanzo e nella novellistica di ambientazione siciliana, tra Otto e Novecento, la recita del rosario assume negli scrittori qui proposti una connotazione peculiare, di ordine stilistico, retorico e propriamente narratologico. In Verga, De Roberto e Tomasi di Lampedusa, infatti, la preghiera predispone spesso all’inserzione repentina di elementi mondani nell’intreccio del racconto; e anzi la sua struttura – iterativa, monotona, litanica – giunge ad essere utilizzata come palinsesto per la rappresentazione di gesti, eventi e sentimenti in chiave antifrastica e deformante rispetto al testo della preghiera stessa. Attraverso i riscontri testuali ritenuti più significativi, il contributo intende offrire una non esaustiva ma rappresentativa esemplificazione delle argomentazioni proposte.
description: A recurring image in novels and novellas of Sicilian setting, between the nineteenth and twentieth centuries, the recitation of the rosary takes on a peculiar connotation in the writers proposed here, of a stylistic, rhetorical, and properly narratological nature. In Verga, De Roberto and Tomasi di Lampedusa, in fact, prayer often predisposes to the sudden insertion of worldly elements in the plot of the story; and indeed, its structure – iterative, monotonous, litanic – comes to be used as a palimpsest for the representation of gestures, events and feelings in an antiphrastic and deforming key with respect to the text of the prayer itself. Through the textual findings considered most significant, the contribution intends to offer a nonexhaustive but representative exemplification of the arguments proposed.
Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy
Creators: name: Chen, Yunching
name: Wu, Jinzi J
name: Huang, Leaf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: We have designed a PEGylated LPD (liposome-polycation-DNA) nanoparticle for systemic, specific, and efficient delivery of small interfering RNA (siRNA) into solid tumors in mice by modification with NGR (aspargine–glycine–arginine) peptide, targeting aminopeptidase N (CD13) expressed in the tumor cells or tumor vascular endothelium. LPD-PEG-NGR efficiently delivered siRNA to the cytoplasm and downregulated the target gene in the HT-1080 cells but not CD13− HT-29 cells, whereas nanoparticles containing a control peptide, LPD-PEG-ARA, showed only little siRNA uptake and gene silencing activity. LPD-PEG-NGR efficiently delivered siRNA into the cytoplasm of HT-1080 xenograft tumor 4 hours after intravenous injection. Three daily injections (1.2 mg/kg) of c-myc siRNA formulated in the LPD-PEG-NGR effectively suppressed c-myc expression and triggered cellular apoptosis in the tumor, resulting in a partial tumor growth inhibition. When doxorubicin (DOX) and siRNA were co-formulated in LPD-PEG-NGR, an enhanced therapeutic effect was observed.
Optimization of Reliability under Different flow state of Multistate Flow Network
Creators: name: Barpanda, Nalini Kanta
name: Dash, Ranjan Kumar
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: reliability
minimal cutset
state space
genetic algorithm

description: This paper focuses on maximizing the reliability of multistate flow network(MFN) by meeting the demand to flow from source to destination. The reliability maximization problem is formulated considering the different flow state of the edges and their corresponding existence probabilities. A method based on genetic algorithm is proposed to maximize the reliability of MFN searching through the state space. Each step of the proposed method is illustrated by taking a suitable example network. The values of computed reliability by the proposed method is exactly same as computed by the deterministic approach. The reliability of some benchmark networks are evaluated under different demand levels. The reliability of a practical example network is evaluated and compared against the reliability value computed by some deterministic approaches of similar interest. The computational time of the proposed method is also compared with these methods. The comparison findings reveal that the proposed method surpasses existing methods on the basis of computed reliability values and computational time.
Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application
Creators: name: Sarkar, Rita
name: Samulski, R Jude
name: Lothrop, Clinton D
name: Kantor, Boris
name: Hirsch, Matthew L
name: Elia, Joseph R
name: Monahan, Paul E
name: Tillson, D Michael
name: Kafri, Tal
name: Sun, Junjiang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Delivery of genes that are larger than the wild-type adeno-associated virus (AAV) 4,681 nucleotide genome is inefficient using AAV vectors. We previously demonstrated in vitro that concurrent proteasome inhibitor (PI) treatment improves transduction by AAV vectors encoding oversized transgenes. In this study, an AAV vector with a 5.6 kilobase (kb) factor VIII expression cassette was used to test the effect of an US Food and Drug Administration–approved PI (bortezomib) treatment concurrent with vector delivery in vivo. Intrahepatic vector delivery resulted in factor VIII expression that persisted for >1 year in hemophilia mice. Single-dose bortezomib given with AAV2 or AAV8 factor VIII vector enhanced expression on average ~600 and ~300%, respectively. Moreover, coadministration of AAV8.canineFVIII (1 × 1013 vg/kg) and bortezomib in hemophilia A dogs (n = 4) resulted in normalization of the whole blood clotting time (WBCT) and 90% reduction in hemorrhages for >32 months compared to untreated hemophilia A dogs (n = 3) or dogs administered vector alone (n = 3). Demonstration of long-term phenotypic correction of hemophilia A dogs with combination adjuvant bortezomib and AAV vector expressing the oversized transgene establishes preclinical studies that support testing in humans and provides a working paradigm to facilitate a significant expansion of therapeutic targets for human gene therapy.
Calibration procedure for testing machine to close the traceability chain for dynamic forces across a frequency range of 0 Hz to 1000 Hz including a template calibration certificate which can be used for forces in the range of 1 N to 1 MN
Creators: name: Gerber Siegfried
name: Nitschke Arnd
name: Neumann Steffen
name: Kumme Rolf
name: Tegtmeier Falk
name: Soares, Oliveira Rafael
name: Machado Renato Reis
name: Mikolaj, Wozniak
name: Haldun, Dizdar
name: Bulent, Aydemir
name: Korhonen Jani
name: Miha, Hiti
Publisher: name: Zenodo
Year: 2023
Subjects: traceability chain
dynamic forces
calibration procedure
DKD standard
calibration certificate

description: DKD guidelines are application documents regarding the DIN EN ISO/IEC 17025 requirements. The guidelines contain a description of the technical, process-related and the organizational procedures which accredited calibration laboratories use as a model for defining internal processes and regulations. DKD guidelines may become an essential component of the quality management manuals of calibration laboratories. By implementing the guidelines, it is ensured that the devices to be calibrated are all treated equally in the various calibration laboratories and that the continuity and verifiability of the work of the calibration laboratories are improved. The DKD guidelines should not impede the further development of calibration procedures and processes. Deviations from guidelines as well as new procedures are allowed in agreement with the accreditation body if there are technical reasons to support this action. Calibrations by accredited laboratories provide the user with the security of reliable measuring results, increase the confidence of customers, enhance competitiveness in the national and international markets, and serve as metrological basis for the monitoring of measuring and test equipment within the framework of quality assurance measures. This guideline is the first official working draft (WD23-03) which has been developed within the 18SIB08 ComTraForce project coordinated by PTB Braunschweig. The project has received funding from the EMPIR programme co-financed by the participating states and from the European Union’s Horizon 2020 research and innovation programme.
description: The ComTraForce project 18SIB08 has received funding from the European Metrology Programme for Innovation and Research (EMPIR) as well as the European Association of National Metrology Institutes (Euramet).
Additional file 1 of Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis media
Creators: name: Schiel, Viktoria
name: Bhattacharya, Ritwija
name: Gupta, Ankur
name: Eftekharian, Kourosh
name: Xia, Anping
name: Santa Maria, Peter L
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs
Creators: name: Arruda, Valder R
name: Bellinger, Dwight A
name: Nichols, Timothy C
name: Basner-Tschakarjan, Etiena
name: Franck, Helen G
name: Stedman, Hansell H
name: High, Katherine A
name: Haurigot, Virginia
name: Mingozzi, Federico
name: Hui, Daniel J
name: Zhou, Shangzhen
name: Chen, Yifeng
name: Wright, J Fraser
name: Radu, Antoneta
name: Buchlis, George
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Muscle represents an attractive target tissue for adeno-associated virus (AAV) vector–mediated gene transfer for hemophilia B (HB). Experience with direct intramuscular (i.m.) administration of AAV vectors in humans showed that the approach is safe but fails to achieve therapeutic efficacy. Here, we present a careful evaluation of the safety profile (vector, transgene, and administration procedure) of peripheral transvenular administration of AAV-canine factor IX (cFIX) vectors to the muscle of HB dogs. Vector administration resulted in sustained therapeutic levels of cFIX expression. Although all animals developed a robust antibody response to the AAV capsid, no T-cell responses to the capsid antigen were detected by interferon (IFN)-γ enzyme-linked immunosorbent spot (ELISpot). Interleukin (IL)-10 ELISpot screening of lymphocytes showed reactivity to cFIX-derived peptides, and restimulation of T cells in vitro in the presence of the identified cFIX epitopes resulted in the expansion of CD4+FoxP3+IL-10+ T-cells. Vector administration was not associated with systemic inflammation, and vector spread to nontarget tissues was minimal. At the local level, limited levels of cell infiltrates were detected when the vector was administered intravascularly. In summary, this study in a large animal model of HB demonstrates that therapeutic levels of gene transfer can be safely achieved using a novel route of intravascular gene transfer to muscle.
Origin of the tetragonal-to-orthorhombic (nematic) phase transition in FeSe: a combined thermodynamic and NMR study
Creators: name: Böhmer, A. E.
name: Arai, T.
name: Hardy, F.
name: Hattori, T.
name: Iye, T.
name: Wolf, T.
name: Löhneysen, H. v.
name: Ishida, K.
name: Meingast, C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The nature of the tetragonal-to-orthorhombic structural transition at $T_s\approx90$ K in single crystalline FeSe is studied using shear-modulus, heat-capacity, magnetization and NMR measurements. The transition is shown to be accompanied by a large shear-modulus softening, which is practically identical to that of underdoped Ba(Fe,Co)$_2$As$_2$, suggesting very similar strength of the electron-lattice coupling. On the other hand, a spin-fluctuation contribution to the spin-lattice relaxation rate is only observed below $T_s$. This indicates that the structural, or "nematic", phase transition in FeSe is not driven by magnetic fluctuations.
Effects of desiccation/oxidation on the potential for bacterially mediated P release from sediments
Creators: name: Mitchell, A
name: Baldwin, D. S
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The effect of desiccation/oxidation on the potential for phosphorus release from reservoir sediments under anoxic conditions was studied. When sediments were exposed to the air and subsequently dried, their ability to release P under anaerobic conditions was severely limited relative to sediments that were not exposed. Anaerobic P release in response to the addition of a toxicant (formaldehyde), bioavailable carbon sources (acetate or glucose), available sulfur (sulfate), and sulfide were used to infer possible causes for the decrease in anaerobic P release as a function of desiccation/oxidation. A substantial reduction in P release occurred in sediments that had not been exposed when formaldehyde was added. This suggests that anaerobic P release may be microbially driven. Addition of acetate and sulfate slightly enhanced P release from nondesiccated sediments, suggesting some C and(or) S limitation of the bacterial processes occurring in these sediments. Substantial P was released when sulfide was added to the nonexposed sediments, indicating that there is a significant amount of P associated with sulfide-reducible minerals (e.g. iron oxyhydroxides). Sulfide addition to exposed sediments released only about one-fourth of the P compared with nonexposed sediments. Furthermore, no additional P was released when sulfate was added to exposed sediments, but P was released in the presence of either glucose or acetate. Together these results indicate that the decrease in potential for P release from exposed sediments was caused by a shift in bacterial community structure (specifically the loss of viable sulfate-reducing bacteria), carbon limitation as a result of drying, and aging of minerals with which P is associated.
Gluon Condensation Signature in the GeV Gamma-Ray Spectra of Pulsars
Creators: name: Zou, Ze-Cheng
name: Huang, Yong-Feng
name: Li, Cheng-Ming
name: Zheng, He-Rui
name: Zhu, Wei
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The accumulation of gluons inside nucleons, i.e., the gluon condensation, may lead to a characteristic broken power-law gamma-ray spectrum in high-energy nucleon collisions. Here we show that the observed spectra of at least 25 sources in the second Fermi Large Area Telescope Catalog of Gamma-ray Pulsars can be well fitted by such a broken power-law function that has only four free parameters. It strongly indicates that the gamma-ray emission from these pulsars is of hadronic origin, but with gluon condensation inside hadrons. It is well known that the quark-gluon distribution in a free nucleon is different from that in a bound nucleon. This work exposes the nuclear $A$ dependence of the gluon condensation effect, where $A$ refers to the baryon number. Our study reveals the gluon condensation under the condition of $A\to\infty$, which may open a new window for eavesdropping on the structure of compact stars on the subnuclear level.
description: 10 pages, 5 figures, 1 table, typos fixed
Additional file 1 of Assessing non-dysfunctional attitudes toward sleep: psychometric properties of the Charlotte Attitudes Toward Sleep scale in Portuguese samples
Creators: name: Tecedeiro, Miguel
name: Reis, Cátia
name: Marôco, João
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1.