cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Refugee Protection in Ghana During COVID-19. Infographic
Creators: name: Segadlo, Nadine
name: Krause, Ulrike
name: Zanker, Franzisca
name: Edler, Hannah
Publisher: name: Universität Osnabrück
Year: 2021
Subjects: subject: Covid-19
subject: Pandemic
subject: Refugees
subject: 320 - Politik

description: Infographic about the effects ofthe COVID-19 pandemic on refugees and their protection in Ghana.
Muhtasari wa maelezo. Athari za janga la COVID-19 kwa wakimbizi na ulinzi wao nchini Kenya, Uganda, Ghana, Nigeria, Afrika Kusini na Zimbabwe
Creators: name: Segadlo, Nadine
name: Krause, Ulrike
name: Zanker, Franzisca
name: Edler, Hannah
Publisher: name: Universität Osnabrück
Year: 2021
Subjects: subject: Covid-19
subject: Pandemic
subject: Refugees
subject: 320 - Politik

description: Janga la sasa la COVID-19 linaathiri watu wote kote ulimwenguni lakini wale walio katika nafasi za hatari, ikiwemo wakimbizi na watu waliohamishwa, wanaweza kuwa katika hatari zaidi. Katika somo la karibuni, tuliangalia ambavyo janga la COVID-19 liliathiri wakimbizi na ulinzi wa kikimbizi katika nchi sita katika Afrika Magharibi, Afrika Mashariki na Afrika Kusini, kwa majina Ghana, Kenya, Nigeria, Afrika Kusini, Uganda, na Zimbabwe, katika mwaka wa kwanza wa janga na mpaka pia February 2021. Kwa kutumia dodoso lisilio la uwakilishi, tulitaka kupata yaliomo ndani katika mitazamo ya watu walio na mandhari nyuma ya kikimbizi, wasomi, wafanyakazi wa serekali na watendaji wa misaada wanaofanya na au kwa wakimbizi. Jumla ya 90 waliohojiwa walijaza dodoso.
CHINA’S GLOBAL ORDER: A NEW PARADIGM IN THE SOUTH TO SOUTH RELATIONS
Creators: name: Contipelli, Ernani
Publisher: name: figshare
Year: 2016
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: This article aims to analyze the evolution of Chinese political foreign policy and its strategy to approach developing and less developed nations. In this context, the relations between China and Latin America appear to reveal the practice of the Beijing Consensus considering their interests: China needs natural resources and new markets for its products, while Latin America needs financial aid and loans to develop its infrastructure and provide social programs. Furthermore, the absence of US from the region and the rise of political movements denouncing the American imperialism of the Washington Consensus are all factors that contribute to the expansion of the Chinese influence. All these considerations allow a discussion concerning the new role of China in developing countries as an expression of a new emerging order in which China is assuming an important role.
title: Bioinspired covalent peptide drug depots in extracellular matrixmediated by transglutaminase Factor XIIIa
Creators: name: Hamm, Prisca
name: Beckmann, Denise
name: Braun, Alexandra
name: Gutmann, Marcus
name: Korb-Pap, Adelheid
name: Lühmann, Tessa
name: Pap, Thomas
name: Meinel, Lorenz
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Nature creates local protein depots by forming covalent bonds to the extracellular matrix (ECM) of tissues. We are translating this natural blueprint for the sustained delivery of therapeutic peptides, that otherwise would be eliminated from the body rapidly. In this study, a myostatin-inhibiting peptide is functionalised with the D-domain of insulin-like growth factor I, a substrate of transglutaminases. Myostatin promotes osteoclast differentiation and bone degradation in joint diseases, therefore myostatin inhibitors have an interesting therapeutic potential against arthritis. The transglutaminase Factor XIIIa (FXIIIa) catalysed the binding of the peptide to ECM proteins, such as laminin and fibronectin, as indicated by tandem mass spectrometry. The immobilised construct suppressed Myostatin activity and pathway activation, demonstrated in 2D and 3D cell culture experiments, and reduced the differentiation of bone marrow-derived macrophages into osteoclasts. This bioinspired platform technology holds the potential to leverage the use of local drug depots, as it substantially reduces the development and manufacturing complexity, stability issues and risks during application of localized drug depots.
A place of fish : subsistence and production for the market in Garogos Island, Maluku, Indonesia
Creators: name: Soselisa, Hermien
Publisher: name: Charles Darwin University
Year: 1995

description: The objective of this study is the description of a small scale artisanal fishing community in Maluku Province in Indonesia which engages in fishing for subsistence and exchange. Maluku and Indonesia are archipelagic regions, and this thesis treats Garogos Island as an example of 'small island communities'. The thesis begins with an overview of the environment, local history and social organization. It then discusses in detail local sea tenure, fishing technology and methods, and economic organization including methods of production and trade. By focusing on the activities for subsistence and for the market, the study attempts to describe the encapsulation of a small 'isolated' island community into the wider world economy and state through the process of change in the technological, socio-cultural and ecological spheres. This process in turn leads to changes in their management of marine resources exploitation. Beside internal changes, fishing communities also face to the presence of large scale commercial fisheries in their waters as a recent phenomenon. Problems emerge because outside large scale fisheries are not always compatible with local small scale fisheries. In fact, the increasing exploitation of sea resources by both locals and outsiders seems to lead to the potential of overfishing. The issue of overfishing is also related to the concept and practice of customary sea tenure by local people. The thesis concludes by suggesting that 'traditional' fishing communities in Maluku are characterized by encapsulation into the modern capitalist economy and the institutions of the state which lead them to dependence on the outside market. The conclusion also brings attention to customary sea tenure which is still important as a basis for development of local communities. However, it needs modification in order to adapt to modern fishing circumstances. In
Nuxurka Guud. Saamaynta Faafida Covid-19 ee qaxootiga iyo ilaalintooda ee wadamada Kenya, Uganda, Ghana, Nigeria, Koonfur Africa iyo Zimbabwe
Creators: name: Segadlo, Nadine
name: Krause, Ulrike
name: Zanker, Franzisca
name: Edler, Hannah
Publisher: name: Universität Osnabrück
Year: 2021
Subjects: subject: Covid-19
subject: Pandemic
subject: Refugees
subject: 320 - Politik

description: Faafida Caabuqa-19 ee hadda jirta waxay saamaysay dhammaan dadka dunida oo dhan laakiin kuwa ku sugan goobaha nugul, oo ay ku jiraan qaxootiga iyo dadka barakacayaasha, ayaa laga yaabaa inay la wajahaan khataro waaweyn. Daraasad dhawaan la sameeyay, waxaan sahminay sida halista Caabuqa-19 uu u saameyay qaxootiga iyo ilaalinta qaxootiga lix waddan oo ku yaal Galbeedka Afrika, Bariga Afrika iyo Koonfurta Afrika, kuwaas oo kala ah Ghana, Kenya, Nigeria, koonfur Africa, Uganda, iyo Zimbabwe, intii lagu jiray sanadkii ugu horeeyay ee safmarka iyo ilaa iyo Febraayo 2021. Anagoo isticmaaleyno xoguruurinta aanan la matalin, waxaan raadineynay inaan helno afkaar ku aadan aragtida dadka asal ahaan kasoo jeeda qaxootiga, aqoonyahanada, saraakiisha dowladda iyo howl wadeenada gargaarka ee la shaqeeya iyo qaxootiga. Isu geyn 90 jawaab celiyayaal ah ayaa buuxiyey xog-ururinta.
อิทธิพลของศาสนากับนาฏศิลป์อินเดียดั้งเดิม
Creators: name: นนทลี รัตนพันธุ์
Publisher: name: สำนักวิทยบริการ มหาวิทยาลัยสงขลานครินทร์ วิทยาเขตปัตตานี
Year: 2020
Subjects: นาฏศิลป์, อินเดีย, ศาสนา, dance, Indian, religions

description: วารสารวิทยบริการ มหาวิทยาลัยสงขลานครินทร์, 31, 1, 270-278
A Model of Text for Experimentation in the Social Sciences
Creators: name: Roberts, Margaret E.
name: Stewart, Brandon M.
name: Airoldi, Edoardo M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Statistical models of text have become increasingly popular in statistics and computer science as a method of exploring large document collections. Social scientists often want to move beyond exploration, to measurement and experimentation, and make inference about social and political processes that drive discourse and content. In this article, we develop a model of text data that supports this type of substantive research. Our approach is to posit a hierarchical mixed membership model for analyzing topical content of documents, in which mixing weights are parameterized by observed covariates. In this model, topical prevalence and topical content are specified as a simple generalized linear model on an arbitrary number of document-level covariates, such as news source and time of release, enabling researchers to introduce elements of the experimental design that informed document collection into the model, within a generally applicable framework. We demonstrate the proposed methodology by analyzing a collection of news reports about China, where we allow the prevalence of topics to evolve over time and vary across newswire services. Our methods quantify the effect of news wire source on both the frequency and nature of topic coverage. Supplementary materials for this article are available online.
Pfupiso yetsvakurudzo. Shanduko dzounziwa nedenda redzihwamupengo ra2019 kune vapoteri nekuchengetedzwa kwavo muKenya, Uganda, Ghana, Nigeria, South Africa nemuZimbabwe
Creators: name: Segadlo, Nadine
name: Krause, Ulrike
name: Zanker, Franzisca
name: Edler, Hannah
Publisher: name: Universität Osnabrück
Year: 2021
Subjects: subject: Covid-19
subject: Pandemic
subject: Refugees
subject: 320 - Politik

description: Dambudziko ririko mazuva ano echidzihwamupengo (COVID19) rinotambudza munhu wese wese pasirose, asi rinonyanya kushusha avo vari panzvimbo dzagara dzisina kumira zvakanaka, dzinosanganisira vanhu vonotiza munyika dzavo vachindogara mune dzimwe nyika (vapoteri) nevamwe vakatamiswa nenzira dzisiri dzekuda kwavo kubva pamisha yavo. Mudzidzo, kana mutsvakurudzo ichangoitwa, tinotarisa kuvhiringwa kwakaitwa zvinhu nedambudziko rechirwere chedzihwamupengo kuvapoteri uyevo kuzvirongwa zvekuchengetedzwa kwavapoteri kubva munyika nhanhatu dzekuMavirira kweAfrica, dzekuMabvazuva kweAfrica, uyevo dzekuChamhembe kweAfrica dzinoti, Ghana, Kenya, South Africa, Uganda, uyewo ne Zimbabwe, kubvira pagore rekutanga redambudziko iri kusvikira, uye kusanganisira mumwedzi waKukadzi wa2021. Tichishandisa mivhunzo isina wayakananga chaiye, tinovavarira kuwana miono yavanhu vanobva, kana kuti vanorarama hupenyu hweupoteri, vadzidzi, makurukota ehurumende, uyevo vanoshanda nezvekubatsira uye kushanda nevapoteri. Vanhu vanosvika makumi mapfumbamamwe (90) vakapindura mivhunzo iyi.
Methods for Missing Data Handling in Randomized Clinical Trials With Nonnormal Endpoints With Application to a Phase III Clinical Trial
Creators: name: Chunpeng Fan
name: Donghui Zhang
name: Wei, Lynn
name: Koch, Gary
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In randomized clinical trials, when the endpoint is the change from baseline at the last scheduled visit, various parametric, semiparametric, and nonparametric methods have been developed to handle the possible missing data due to dropouts. Although the last observation carried forward (LOCF) and the mixed-effects model for repeated measures (MMRM) have been extensively compared and widely used, they may lead to biased results when the required distributional or missing mechanism assumptions are not satisfied. Nonparametric missing data handling methods including the last rank carried forward (LRCF) and mean rank imputation (MRI) relax the underlying distributional assumptions; however, conditions for them to be valid have been investigated to a very limited extent. This article rigorously derives asymptotic properties of the MRI method and proves its validity to test the primary endpoint under certain mild distributional and missing mechanism assumptions. The test-based estimator for the location difference between the treatment and the control groups is also derived when the randomized clinical trial has two arms under a location shift assumption. The investigated methods are applied to an illustrative phase III clinical trial. Simulation studies based on the empirical distributions from the illustrative clinical trial and additional intensive simulation studies, based on various prespecified distributions and missing mechanisms, were conducted to compare the MRI method with selected traditional methods including LOCF, MMRM, and LRCF and they confirmed the better performance of the MRI method in terms of the Type I error rate control and the power under certain mild conditions.
Isifinqo socwayisiso. Imiphumela yobhubhane lweCovid-19 kuziphepheli kanye lokuvikelwa kwazo eKenya, Uganda, Ghana, Nigeria, South Africa laseZimbabwe
Creators: name: Segadlo, Nadine
name: Krause, Ulrike
name: Zanker, Franzisca
name: Edler, Hannah
Publisher: name: Universität Osnabrück
Year: 2021
Subjects: subject: Covid-19
subject: Pandemic
subject: Refugees
subject: 320 - Politik

description: Umkhuhlane wakulezi insuku oweCOVID-19 uhlasela bonke abantu umhlaba wonke jikelele, kodwa kulobungozi kakhulu kulabo abasesimeni esibuthakathaka, okuhlanganisela iziphepheli kanye labantu abangelamakhaya. Kucwayisiso olusanda kuphela, sikhangela ukuthi umkhuhlane weCovid-19 uphambanise kanjani impilo zabantu abayiziphepheli kanye lokuvikeleka kwabo emazweni ayisithupha asentshonalanga, empumalanga kanye lasezansi kwelizwekazi leAfrica. Amazwe lawa ahlanganisela, iGhana, Kenya, Nigeria, South Africa, Uganda leZimbabwe. Ucwayisiso lolu lukhangela kusukela emnyakeni wokuqala wobhubhane lweCovid-19 kuze kufike, njalo kuhlanganisela inyanga kaNhlolanja 2021. Sisebenzise uluhlu lwemibuzo ebantwini abambalwa abakhethiweyo, sifuna ukuzwisisa kabanzi imibono yeziphepheli, izifundiswa, izisebenzi zikahulumende labezenhlanganiso ezisebenza leziphepheli. Inani labantu abaphedule imibuzo lingamatshumi ayisitshiyagalolunye.
Methods for Missing Data Handling in Randomized Clinical Trials with Non-normal Endpoints with Application to a Phase III Clinical Trial
Creators: name: Chunpeng Fan
name: Donghui Zhang
name: Wei, Lynn
name: Koch, Gary
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In randomized clinical trials, when the endpoint is the change from baseline at the last scheduled visit, various parametric, semiparametric, and nonparametric methods have been developed to handle the possible missing data due to dropouts. Although the last observation carried forward (LOCF) and the mixed model for repeated measures (MMRM) have been extensively compared and widely used, they may lead to biased results when the required distributional or missing mechanism assumptions are not satisfied. Nonparametric missing data handling methods including the last rank carried forward (LRCF) and mean rank imputation (MRI) relax the underlying distributional assumptions; however, conditions for them to be valid have been investigated to a very limited extent. This paper rigorously derives asymptotic properties of the mean rank imputation method and proves its validity to test the primary endpoint under certain mild distributional and missing mechanism assumptions. The test-based estimator for the location difference between the treatment and the control groups is also derived when the randomized clinical trial has two arms under a location shift assumption. The investigated methods are applied to an illustrative phase III clinical trial. Simulation studies based on the empirical distributions from the illustrative clinical trial and additional intensive simulation studies, based on various pre-specified distributions and missing mechanisms, were conducted to compare the mean rank imputation method with selected traditional methods including LOCF, MMRM, and LRCF and they confirmed the better performance of the mean rank imputation method in terms of the type I error rate control and the power under certain mild conditions.
Takaitaccen Bayani. Tasirin Cutar Covid-19 akan 'Yan Gudun Hijira da Kareeyan su a Kenya, Uganda, Ghana, Nigeria, Afirka ta Kudu da Zimbabwe
Creators: name: Segadlo, Nadine
name: Krause, Ulrike
name: Zanker, Franzisca
name: Edler, Hannah
Publisher: name: Universität Osnabrück
Year: 2021
Subjects: subject: Covid-19
subject: Pandemic
subject: Refugees
subject: 320 - Politik

description: Cutar ta COVID-19 na yanzu tana shafar duk mutane a duk duniya amma waɗanda ke cikin matsayi na musamman, gami da 'yan gudun hijira da mutanen da suka rasa matsugunai, na iya fuskantar haɗari mafi girma. A cikin wani bincike na baya-bayan nan, mun gano yadda cutar ta COVID-19 ta shafi 'yan gudun hijira da kare 'yan gudun hijira a kasashe shida a yammacin Afirka, Gabashin Afirka da Kudancin Afirka, wato Ghana, Kenya, Nigeria, Afirka ta Kudu, Uganda, da Zimbabwe, a lokacin farko. shekarar cutar har zuwa Fabrairu 2021. Yin amfani da tambayoyin da ba na wakilci ba, muna neman samun fahimtar ra'ayoyin mutanen da suka fito daga 'yan gudun hijira, malamai, jami'an gwamnati da masu aikin agaji da ke aiki tare da kuma ga 'yan gudun hijira. Jimillar masu amsawa 90 ne suka cika a cikin takardar.
A model of text for experimentation in the social sciences
Creators: name: Roberts, Margaret E.
name: Stewart, Brandon M.
name: Airoldi, Edoardo M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Statistical models of text have become increasingly popular in statistics and computer science as a method of exploring large document collections. Social scientists often want to move beyond exploration, to measurement and experimentation, and make inference about social and political processes that drive discourse and content. In this paper, we develop a model of text data that supports this type of substantive research. Our approach is to posit a hierarchical mixed membership model for analyzing topical content of documents, in which mixing weights are parameterized by observed covariates. In this model, topical prevalence and topical content are specified as a simple generalized linear model on an arbitrary number of document-level covariates, such as news source and time of release, enabling researchers to introduce elements of the experimental design that informed document collection into the model, within a generally applicable framework. We demonstrate the proposed methodology by analyzing a collection of news reports about China, where we allow the prevalence of topics to evolve over time and vary across newswire services. Our methods quantify the effect of news wire source on both the frequency and nature of topic coverage.
title: Role of protein kinase A isoforms in healthy and diabetic kidneys
Creators: name: Prüschenk, Sally
name: Harloff, Manuela
name: Ma, Yuliang
name: Taylor, Susan
name: Schlossmann, Jens
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Diabetic nephropathy (DN) is a major universal problem caused by hyperglycaemia and might require dialysis or renal replacement. Still, the signaling events causing diabetic kidney disease and the effective treatment options are poorly understood. Alterations in the signaling of cyclic nucleotides and its regulated kinases might be involved in the development of this disease. Protein kinase A (PKA) signaling pathways are known to modulate extracellular matrix metabolism in diabetic kidneys. Multiple isoforms of PKA regulatory and catalytical subunits exist, leading to functional specificities of this kinase. As PKA was further described to exert antifibrotic effects, it might be important in prevention of fibrosis or DN. Localization of the specific PKA subunits as well as other signaling proteins involved in this pathway, however, still need to be explored comprehensively. The aim of our project is to get an overview about distribution pattern of different PKA subunits in various cell types of the kidney. Furthermore, amount of PKA expression in healthy and diabetic kidneys are compared. To achieve these goals, type 1 diabetes was induced with streptozotocin in wild-type (WT) and endothelial NOS knockout (eNOS-KO) mice for 12 weeks. Afterwards, kidneys were analyzed by immunohistochemistry and stained with specific antibodies for different PKA subunits and markers for specialized cell types of the kidney. Amount of PKA-Cα and PKA-Cβ expression was quantified and compared between healthy and diabetic kidneys. Our data thereby revealed that catalytic subunits of PKA show a different distribution pattern in specialized cell types of the kidney, but also a different intracellular localization. Furthermore, PKA-Cα appears to be the predominant isoform in a lot of cell types in the kidney. The amount of catalytic subunit expression also varies between healthy and diabetic kidneys. Therefore, PKA might play an important role in pathophysiology of DN and targeting the PKA signaling pathway could be a potential treatment approach.
Mercury and methylmercury in a reservoir during seasonal variation in hydrology and circulation
Creators: name: Wildman, Richard A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: This study explored the effect of seasonally varying inflow hydrology and circulation on total mercury (Hg) and methylmercury (MeHg) in the water column of a warm, temperate reservoir. The study site in Grand Lake, Oklahoma, is >80 km long and usually 36 m deep at its dam. During this study, aside from 2 large, storm-driven springtime events, drought caused low inflows. During maximal summer stratification, the surface mixed layer was 8–11 m thick, water below was anoxic, and inflows entered as an interflow. Total Hg in filtered samples was <4 ng/L with an interquartile range of 0.27–0.96 ng/L. Highest concentrations occurred in spring and summer, and lowest concentrations followed overturn. In filtered samples, MeHg was ≤0.62 ng/L with an interquartile range of 0.01–0.08 ng/L. Highest concentrations of MeHg occurred in some large inflows and in anoxic summertime bottom water in specific locations where total suspended sediment was also elevated. During this study, Hg concentrations in Grand Lake were driven by inflow hydrology when inflows were high. During low inflows, biogeochemistry controlled the enrichment of MeHg in specific locations of the anoxic bottom water and sequestered both Hg species in autumn. This sequestration suggests that Grand Lake decreases watershed-derived Hg pollution downstream. Occurrence of elevated Hg and MeHg concentrations primarily in large inflows and anoxic bottom water suggests that exposure of biota to Hg species is greatest when floods enter the reservoir because Hg enrichment in deep, anoxic water does not coincide with the habitat of most fauna.
title: Targeted Inhibition of HSD17B13 - a new therapeutic option in steatotic liver disease?
Creators: name: Kraus, Nico
name: Fuhrmann, Dominik
name: Ohngemach, Magdalena
name: Schulz, Marcel
name: Zeuzem, Stefan
name: Welsch, Christoph
name: Ortiz, Cristina
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) is an enzyme associated with lipid droplets and mainly expressed in hepatocytes. Whole genome sequencing has identified HSD17B13 as a potential molecular target with an important role in lipid metabolism. Targeted inhibition of enzyme function therefore is considered a potential therapeutic strategy in the treatment of steatotic liver disease (SLD). BI-3231, the first selective HSD17B13 inhibitor, was successfully used by Alcober-Boquet, Kraus et al. for in vitro therapy of palmitic acid induced hepatocellular lipotoxicity. The study aimed to investigate the effects of HSD17B13 inhibition using the hepatocyte human cell line (HepG2) and primary mouse hepatocytes in vitro to characterize the role of HSD17B13 in SLD and validate its therapeutic suitability. Lipotoxicity was induced in HepG2 cells and freshly isolated mouse hepatocytes by exposure with palmitic acid and co-incubation with BI-3231 to evaluate the protective effect of HSD17B13 inhibition. Under lipotoxic stress, triglyceride accumulation was significantly reduced in BI-3231 treated cells compared to untreated human and mouse control hepatocytes. In addition, BI-3231 treatment resulted in a significant improvement in hepatocyte proliferation, cell differentiation and lipid homeostasis. Mechanistically, BI-3231 increased mitochondrial respiratory function without affecting β-oxidation. BI-3231 inhibited the lipotoxic effects of palmitic acid treatment in hepatocytes, highlighting the potential of targeting HSD17B13 as a specific therapeutic approach in SLD. We are now further validating our cell culture findings in standardized western diet based animal models of metabolic dysfunction associated steatotic liver disease (MASLD).
Risk analysis for confined space entries: Critical analysis of four tools applied to three risk scenarios
Creators: name: Burlet-Vienney, Damien
name: Yuvin Chinniah
name: Bahloul, Ali
name: Roberge, Brigitte
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Investigation reports of fatal confined space accidents nearly always point to a problem of identifying or underestimating risks. This paper compares 4 different risk analysis tools developed for confined spaces by applying them to 3 hazardous scenarios. The tools were namely 1. a checklist without risk estimation (Tool A), 2. a checklist with a risk scale (Tool B), 3. a risk calculation without a formal hazard identification stage (Tool C), and 4. a questionnaire followed by a risk matrix (Tool D). Each tool's structure and practical application were studied. Tools A and B gave crude results comparable to those of more analytic tools in less time. Their main limitations were lack of contextual information for the identified hazards and greater dependency on the user's expertise and ability to tackle hazards of different nature. Tools C and D utilized more systematic approaches than tools A and B by supporting risk reduction based on the description of the risk factors. Tool D is distinctive because of 1. its comprehensive structure with respect to the steps suggested in risk management, 2. its dynamic approach to hazard identification, and 3. its use of data resulting from the risk analysis.
title: Novel selenium compounds as potent inhibitors of ferroptosis
Creators: name: Merkel, Melanie
name: Saurin, Matheo
name: Matzkeit, Marie
name: Nickel, Antonia
name: Peter-Ventura, Alejandra
name: Schlitzer, Martin
name: Culmsee, Carsten
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Ferroptosis is a caspase-independent form of regulated cell death, characterized by iron-dependent accumulation of reactive oxygen species (ROS), primarily through lipid peroxidation and mitochondrial ROS formation1. Decreased activity of glutathione peroxidase 4 (GPx4) and increased lipoxygenase (LOX) activation are established triggers of ferroptosis. The seleno-enzyme GPx4 plays a crucial antioxidative role by reducing lipid hydroperoxides, thereby interrupting the lipid peroxidation chain reaction. The synthetic organoselenium compound ebselen mimics the antioxidant role of GPx4 and is under investigation for the treatment of various diseases. This study introduces novel selenium compounds derived from ebselen and assesses their potential for ferroptosis inhibition in neuronal HT22 cells. The novel selenium compounds demonstrated enhanced protective activity against both erastin- and RSL3-induced oxidative cell death compared to the scaffold compound ebselen. The protective effects were observed in a time- and concentration-dependent manner on ferroptosis hallmarks, including lipid peroxidation, ROS production, and mitochondrial disruption. The structurally modified selenium compounds exhibited robust protection at concentrations tenfold lower than ebselen. Remarkably, the diselenides, featuring two identical molecules linked by a selenium-selenium bond, displayed significantly stronger protective effects compared to the respective benzisoselenazole compounds, surpassing predictions based on the calculated molarity. The pronounced protective effects of these novel selenium compounds underscore their potential as innovative therapeutic candidates for attenuating ferroptosis.
Risk analysis for confined space entries: critical analysis of four tools applied to three risk scenarios
Creators: name: Burlet-Vienney, Damien
name: Yuvin Chinniah
name: Bahloul, Ali
name: Roberge, Brigitte
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Investigation reports of fatal confined space accidents nearly always point to a problem of identifying or underestimating risks. This paper compares 4 different risk analysis tools developed for confined spaces by applying them to 3 hazardous scenarios. The tools were namely (i) a checklist without risk estimation (Tool A), (ii) a checklist with a risk scale (Tool B), (iii) a risk calculation without a formal hazard identification stage (Tool C) and (iv) a questionnaire followed by a risk matrix (Tool D). Each tool's structure and practical application were studied. Tools A and B gave crude results comparable to those of more analytic tools in less time. Their main limitations were lack of contextual information for the identified hazards and greater dependency on the user's expertise and ability to tackle hazards of different nature. Tools C and D utilized more systematic approaches than tools A and B by supporting risk reduction based on the description of the risk factors. Tool D is distinctive because of (i) its comprehensive structure with respect to the steps suggested in risk management, (ii) its dynamic approach to hazard identification and (iii) its use of data resulting from the risk analysis.
title: Fluorescent chlorido[N,N′-bis(methoxy/hydroxy)salicylidene-1,2-bis(4-methoxyphenyl)ethylenediamine]iron(III) complexes as anticancer agents
Creators: name: Bernkop-Schnürch, Astrid
name: Chavooshi, Donja
name: Descher, Hubert
name: Leitner, Daniel
name: Talasz, Heribert
name: Hermann, Martin
name: Wurst, Klaus
name: Hohloch, Stephan
name: Gust, Ronald
name: Kircher, Brigitte
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Metal complexes in cancer therapy are well-established. Since iron complexes have also shown potential, the effect of chlorido[N,N′-disalicylidene-1,2-bis(4- methoxyphenyl)-ethylenediamine]iron(III) complexes with methoxy groups (C1–C3) or hydroxy groups (C4–C6) at positions 3, 4, or 5 of the salicylidene moieties was evaluated on human MDA-MB 231 breast cancer and HL-60 leukemia cells. Methoxylated complexes (C1-C3) demonstrated concentration-dependent inhibition of proliferation, migration, and metabolic activity, with C2 exhibiting the highest potency, followed by C3 and C1. Notably, C2 displayed remarkable cytotoxicity (IC50 of 4.2 μM), outperforming even cisplatin (IC50 of 27.9 μM) by 6.6-fold. In contrast, hydroxylated complexes C4-C6 exhibited minimal activity even at the highest concentrations, attributed to a lack of cellular uptake. C2 induced a dual mode of cell death, involving ferroptosis and necroptosis, with ferroptosis dominating at higher concentrations. Alterations in cellular morphology, intracellular ferrous iron, and increased concentration of lipid reactive oxygen species confirmed the involvement of ferroptosis. Accordingly, C2 could be identified as a promising lead compound for the development of drug candidates capable of inducing ferroptosis.
Template-Based Models for Genome-Wide Analysis of Next-Generation Sequencing Data at Base-Pair Resolution
Creators: name: Blocker, Alexander W.
name: Airoldi, Edoardo M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We consider the problem of estimating the genome-wide distribution of nucleosome positions from paired-end sequencing data. We develop a modeling approach based on nonparametric templates to control for the variability along the sequence of read counts associated with nucleosomal DNA due to enzymatic digestion and other sample preparation steps, and we develop a calibrated Bayesian method to detect local concentrations of nucleosome positions. We also introduce a set of estimands that provides rich, interpretable summaries of nucleosome positioning. Inference is carried out via a distributed Hamiltonian Monte Carlo algorithm that can scale linearly with the length of the genome being analyzed. We provide MPI-based Python implementations of the proposed methods, stand-alone and on Amazon EC2, which can provide inferences on an entire Saccharomyces cerevisiae genome in less than 1 hr on EC2. We evaluate the accuracy and reproducibility of the inferences leveraging a factorially designed simulation study and experimental replicates. The template-based approach we develop here is also applicable to single-end sequencing data by using alternative sources of fragment length information, and to ordered and sequential data more generally. It provides a flexible and scalable alternative to mixture models, hidden Markov models, and Parzen-window methods. Supplementary materials for this article are available online.
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro.
Creators: name: Cooper, Fay
name: Gentsch, George E
name: Mitter, Richard
name: Bouissou, Camille
name: Healy, Lyn E
name: Rodriguez, Ana Hernandez
name: Smith, James C
name: Bernardo, Andreia S
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Model organisms
Tumour Biology
Signalling & Oncogenes
Gene Expression
Genetics & Genomics
Developmental Biology
Genome Integrity & Repair
Human Biology & Physiology
Stem Cells
Chemical Biology & High Throughput
Computational & Systems Biology

description: The spinal cord emerges from a niche of neuromesodermal progenitors (NMPs) formed and maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo. NMPs can be generated from human pluripotent stem cells and hold promise for spinal cord replacement therapies. However, NMPs are transient, which compromises production of the full range of rostrocaudal spinal cord identities in vitro. Here we report the generation of NMP-derived pre-neural progenitors (PNPs) with stem cell-like self-renewal capacity. PNPs maintain pre-spinal cord identity for 7-10 passages, dividing to self-renew and to make neural crest progenitors, while gradually adopting a more posterior identity by activating colinear HOX gene expression. The HOX clock can be halted through GDF11-mediated signal inhibition to produce a PNP and NC population with a thoracic identity that can be maintained for up to 30 passages.
title: The role of spatial scales and habitat heterogeneity in patterns and drivers of deep-sea benthic biodiversity and ecosystem functioning
Creators: name: Ciraolo, Alessia Caterina
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: Deep-sea environments support ecosystem functioning and services, however, the challenge in accessing deep-sea sediments limits intensive investigations of interactions between diversity, functioning, and spatial heterogeneity. The influence of spatial heterogeneity strongly depends on the scale of study, adding to the challenge. Nonetheless, understanding the potential role of spatial heterogeneity can inform efforts to protect and conserve deep-sea environments. In field experiments, I examined potential effects of different scales of spatial heterogeneity - habitat heterogeneity (large scale, 100s of km), a natural water column oxygen gradient (medium scale, tens of km), and organic matter addition (small scale, cm to m) - on deep-sea benthic ecosystem function and biodiversity. I found that large-scale habitat heterogeneity affects benthic macro- and microbial community assemblages, as well as functional and taxonomic infaunal diversity but with no obvious effect on benthic nutrient fluxes. Whereas quantity and quality of organic matter best explained variation in microbial community composition, interaction of several environmental factors acting over a large spatial scale complicated understanding of variation in infaunal communities. At a medium spatial scale (hypoxia), the quantity and quality of food shaped infaunal community variation where filter-feeder polychaetes dominated surface sediments. Bioturbation features decreased spatially with decreasing O2 levels and response to the O2 gradient varied with scale. The smaller video camera field of view suggested significantly lower megafaunal density and diversity during the period of reduced oxygen concentrations, but not in sediment trace diversity and density. In contrast, the larger field imaged with rotary sonar documented biological pit distribution, a significantly greater proportion of reworked seafloor area, and increases in pit size with increased oxygen levels. Furthermore, North Pacific infaunal composition could not explain variation in nutrient fluxes (mostly influxes) in relation to hypoxia. In contrast to microbial community composition that explained variation in benthic nutrient flux and organic matter degradation among three Atlantic continental slope habitats. At small scales, phytodetrital deposition did not affect oxygen consumption and short-term nutrient cycling. However, adding labeled phytodetritus demonstrated that polychaetes in particular influence rapid carbon uptake and C cycling, irrespective of bottom-water oxygen concentrations.
Revealing the Anti-Cancer Potential of 1,2,3-Triazole-Isonicotinate Derivatives Targeting EGFR Kinase Inhibition in MCF-7 Cancer Cells: Design, Synthesis, Biological Evaluation, and In Silico Studies
Creators: name: Alshamari, Asma Khalaf
name: Abdella, Faiza I. A.
name: AlRashidi, Aljazi Abdullah
name: Alshammari, Mona Zaheed
name: Alshammari, Hissah Khashman
name: Alsaif, Nuha Othman S.
name: Malah, Tamer El
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Click chemistry was used to synthesize a new library of 1,2,3-triazole-isonicotinate derivatives 8–13 using copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) between mono- or bis 2,6-ethynylisonicotinate 3,4, and aromatic azides derivatives 5–7 with high yields (89–96%). These compounds were evaluated for their antiproliferative activity against hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7), and colon cancer (HCT-116) cell lines, alongside a healthy non-cancerous skin fibroblast cell line (BJ-1). As compared with the reference drug, all new triazole-isonicotinate compounds have significantly greater cytotoxicity against colon and breast cancer cells, while compounds 13 and 10 have moderate cytotoxicity against liver cancer cells. The molecular docking study correlates the compound’s biological activity with its ability to establish stable interactions with protein-ligand complexes in the relevant biological targets. Compound 13 demonstrated a strong ability to induce apoptosis and cause cell cycle arrest in MCF-7 cells, along with significant inhibitory activity against the epidermal growth factor receptor (EGFR). These preliminary findings suggest that 1,2,3-triazole-isonicotinate derivatives, particularly compound 13, hold potential as candidates for further investigation as anticancer agents for breast cancer treatment.
title: Inhalation of biologics with transglutaminases results in long-lasting pulmonary drug exposure
Creators: name: Kappus, Maximilian
name: Hauptstein, Niklas
name: Hamm, Prisca
name: Braun, Alexandra
name: Gutmann, Marcus
name: Wurzel, Joel
name: Drießen, Marc
name: Lühmann, Tessa
name: Brand, Theresa
name: Lorenz, Kristina
name: Meinel, Lorenz
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Approved lung depots of biological therapeutics have represented a gap in treatment options for decades, caused by the limited number of excipients approved for inhalation, none of which is applicable for engineering lasting drug depots. In the present text, we outline the results of a proof-of-concept study on a bio-inspired strategy used to address this issue. In the study, biologics, and factor XIIIa - a marketed transglutaminase (TGase) - were inhaled by mice to catalyze covalent bonding between the biological therapeutic and the surface of the lungs. In specific, genetically engineered interferon alpha-2a (IFN-α2a) fusion proteins were designed and elongated by a C-terminal TGase substrate peptide sequence. In vitro, those constructs bound to artificial extracellular matrix (ECM) and to fibronectin as main component of ECM. Binding partners of TGase in mice lungs were investigated using LC-MS/MS. In vivo, co-inhalation of this IFN-α2a fusion protein with TGase using a commonly available Pari-Boy® was found to significantly increase the mice’s IFN-α2a lung exposure by about twelvefold and lasted for at least 48 hours after inhalation compared with the inhalation of the IFN-α2a without TGase, for which IFN-α2a levels approached physiological levels within eight hours. Biological stability and activity of the proteins during nebulization was checked previously. The generic nature of using fusion proteins with TGase substrate peptide sequences and TGase points to a universal platform for engineering pulmonary drug depots. The employed enzymatic strategy addresses the treatment gap – namely non-existent lung depots for biological therapeutics – with an attractive design for clinical translation, thereby expanding the armament of tools to use in the fight against lung diseases.
DESCRIPTION OF PEDAGOGICAL TECHNOLOGY AND PROBLEMATIC TEACHING TECHNOLOGY
Creators: name: RAKHIMOV OKTYABR DUSTKABILOVICH
name: MANZAROV YUSUFJON KHURRAMOVICH
name: KARSHIYEV ALISHER ESHMAMATOVICH
name: SULAYMANOVA SHOHSANAM ABDUSAMADOVNA
Publisher: name: Проблемы современной науки и образования
Year: 2020
Subjects: TECHNOLOGY
CLASSIFICATION
EDUCATIONAL TECHNOLOGY
PEDAGOGICAL TECHNOLOGY
INNOVATION
TEACHING METHODS
PROBLEM EDUCATION
ТЕХНОЛОГИЯ
КЛАССИФИКАЦИЯ
ОБРАЗОВАТЕЛЬНАЯ ТЕХНОЛОГИЯ
ПЕДАГОГИЧЕСКАЯ ТЕХНОЛОГИЯ
ИННОВАЦИЯ
МЕТОДИКА ОБУЧЕНИЯ
ПРОБЛЕМНОЕ ОБУЧЕНИЕ

description: The article gives brief information on educational and pedagogical technologies, educational technology in higher education, educational innovations, characteristics and classification of pedagogical technologies according to their degree of use, philosophical foundations, scientific concept, and modernization of traditional education. The issues of technology and the essence of problem-based learning, their content, basic forms, advantages and disadvantages, as well as methods for creating problem-solving tasks and problematic situations during classes are highlighted.