cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of Incorporating interactive workshops into bedside teaching: completion of a multi-modal rheumatology rotation significantly increases internal medicine residents’ competency and comfort with comprehensive knee examinations
Creators: name: Kwiatkowski, Alysia
name: Shakoor, Najia
name: Manadan, Augustine
name: Block, Joel A.
name: Khandelwal, Sonali
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 3.
Additional file 2 of Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes
Creators: name: Kadota, Yoshito
name: Kawakami, Takashige
name: Sato, Masao
name: Suzuki, Shinya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Computational Biology

description: Additional file 2: Table S2. Sequence information of siRNAs targeting mouse Mest.
Interactions between the gut microbiota, short-chain fatty acids and the immune system in pediatric patients undergoing hematopoietic stem cell transplantation
Creators: name: Nastasi, Claudia <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/38 Pediatria generale e specialistica
BIO/19 Microbiologia

description: The gut microbiota (GM) is essential for human health and contributes to several diseases; indeed it can be considered an extension of the self and, together with the genetic makeup, determines the physiology of an organism. 
In this thesis has been studied the peripheral immune system reconstitution in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation (aHSCT) in the early phase; in parallel, have been also explored the gut microbiota variations as one of the of primary factors in governing the fate of the immunological recovery, predisposing or protecting from complications such as the onset of acute graft-versus-host disease (GvHD).
Has been demonstrated, to our knowledge for the first time, that aHSCT in pediatric patients is associated to a profound modification of the GM ecosystem with a disruption of its mutualistic asset. aGvHD and non-aGvHD subjects showed differences in the process of GM recovery, in members abundance of the phylum Bacteroidetes, and in propionate fecal concentration; the latter are higher in the pre-HSCT composition of non-GvHD subjects than GvHD ones. 
Short-chain fatty acids (SCFAs), such as acetate, butyrate and propionate, are end-products of microbial fermentation of macronutrients and distribute systemically from the gut to blood. For this reason, has been studied their effect in vitro on human DCs, the key regulators of our immune system and the main player of aGvHD onset. Has been observed that propionate and, particularly, butyrate show a strong and direct immunomodulatory activity on DCs reducing inflammatory markers such as chemokines and interleukins.
This study, with the needed caution, suggests that the pre-existing GM structure can be protective against aGvHD onset, exerting its protective role through SCFAs. They, indeed, may regulate cell traffic within secondary lymphoid tissues, influence T cell development during antigen recognition, and, thus, directly shape the immune system.
Additional file 1 of Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes
Creators: name: Kadota, Yoshito
name: Kawakami, Takashige
name: Sato, Masao
name: Suzuki, Shinya
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Computational Biology

description: Additional file 1: Table S1. Primer information.
Ribosome-inactivating proteins and their immunotoxins for cancer therapy: insights into the mechanism of cell death
Creators: name: Mercatelli, Daniele <1982>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/04 Patologia generale

description: Ribosome-inactivating proteins (RIPs) are a family of plant toxic enzymes that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death involving different and still not completely understood pathways. The high cytotoxic activity showed by many RIPs makes them ideal candidates for the production of immunotoxins (ITs), chimeric proteins designed for the selective elimination of unwanted or malignant cells. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively employed to construct anticancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells.
Here we investigated the anticancer properties of two saporin-based ITs, anti-CD20 RTX/S6 and anti-CD22 OM124/S6, designed for the experimental treatment of B-cell NHLs. Both ITs showed high cytotoxicity towards CD20-positive B-cells, and their antitumor efficacy was enhanced synergistically by a combined treatment with proteasome inhibitors or fludarabine. Furthermore, the two ITs showed differencies in potency and ability to activate effector caspases, and a different behavior in the presence of the ROS scavenger catalase. Taken together, these results suggest that the different carriers employed to target saporin might influence saporin intracellular routing and saporin-induced cell death mechanisms. 
We also investigated the early cellular response to stenodactylin, a recently discovered highly toxic type 2 RIP representing an interesting candidate for the design and production of a new IT for the experimental treatment of cancer.
Two-Dimensional Bin Packing Problem with Guillotine Restrictions
Creators: name: Pietrobuoni, Enrico <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MAT/09 Ricerca operativa

description: This thesis, after presenting recent advances obtained for the two-dimensional bin packing problem, focuses on the case where guillotine restrictions are imposed.
A mathematical characterization of non-guillotine patterns is provided and the relation between the solution value of the two-dimensional problem with guillotine restrictions and the two-dimensional problem unrestricted is being studied from a worst-case perspective.
Finally it presents a new heuristic algorithm, for the two-dimensional problem with guillotine restrictions, based on partial enumeration, and computationally evaluates its performance on a large set of instances from the literature.
Computational experiments show that the algorithm is able to produce proven optimal solutions for a large number of problems, and gives a tight approximation of the optimum in the remaining cases.
Structural and functional characterization of
Group B Streptococcus pilus 2b
Creators: name: Lazzarin, Maddalena <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: BIO/11 Biologia molecolare

description: Group B Streptococcus (GBS) is a Gram-positive human pathogen representing one of the most common causes of life-threatening bacterial infections such as sepsis and meningitis in neonates. Covalently polymerized pilus-like structures have been discovered in GBS as important virulence factors as well as vaccine candidates. Pili are protein polymers forming long and thin filamentous structures protruding from bacterial cells, mediating adhesion and colonization to host cells. Gram-positive bacteria, including GBS, build pili on their cell surface via a class C sortase-catalyzed transpeptidation mechanism from pilin protein substrates that are the backbone protein forming the pilus shaft and two ancillary proteins. Also the cell-wall anchoring of the pilus polymers made of covalently linked pilin subunits is mediated by a sortase enzyme. GBS expresses three structurally distinct pilus types (type 1, 2a and 2b). Although the mechanisms of assembly and cell wall anchoring of GBS types 1 and 2a pili have been investigated, those of pilus 2b are not understood until now. Pilus 2b is frequently found in ST-17 strains that are mostly associated with meningitis and high mortality rate especially in infants.
In this work the assembly mechanism of GBS pilus type 2b has been elucidated by dissecting through genetic, biochemical and structural studies the role of the two pilus-associated sortases. The most significant findings show that pilus 2b assembly appears “non-canonical”, differing significantly from current pilus assembly models in Gram-positive pathogens. Only sortase-C1 is involved in pilin polymerization, while the sortase-C2 does not act as a pilin polymerase, but it is involved in cell-wall pilus anchoring. Our findings provide new insights into pili biogenesis in Gram-positive bacteria. Moreover, the role of this pilus type during host infection has been investigated. By using a mouse model of meningitis we demonstrated that type 2b pilus contributes to pathogenesis of meningitis in vivo.
Medical irradiation studies at KIT accelerators
Creators: name: Mayer, Katharina
name: Ferrari, Alfredo
name: Cecilia, Angelica
name: Mueller, Anke-Susanne
name: Bruendermann, Erik
name: Nasse, Michael
name: Stengl, Christina
name: Seco, J.
name: Schwarz, Markus
Publisher: name: JACoW Publishing
Year: 2024
Subjects: Accelerator Physics
mc8-application-of-accelerators-technology-transfer-industrial-relations-and-outreach - MC8: Application of Accelerators
Technology Transfer
Industrial Relations
and Outreach
MC8.A28 - MC8.A28 Medical Applications

description: Radiation therapy is an important oncological treatment method in which the tumor is irradiated with ionizing radiation. In recent years, the study of the beneficial effects of short intense radiation pulses (FLASH effect) or spatially fractionated radiation (MicroBeam/MiniBeam) have become an important research field. Systematic studies of this type often require research accelerators that are capable of generating the desired short intense pulses and, in general, possess a large and flexible parameter space for investigating a wide variety of irradiation methods. The KIT accelerators give access to complementary high-energy and time-resolved radiation sources. While the linac-based electron accelerator FLUTE (Ferninfrarot Linac- und Testexperiment) can generate ultrashort electron bunches, the electron storage ring KARA (Karlsruhe Research Accelerator) provides a source of pulsed X-rays. In this contribution, first dose measurements at FLUTE and KARA, as well as simulations using the Monte Carlo simulation program FLUKA are presented.
Additional file 1 of Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study
Creators: name: Beermann, Mary Lou
name: Homma, Sachiko
name: Miller, Jeffrey Boone
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Additional figures.
Mitochondrial DNA rearrangements during human aging: a study on liver, muscle and adipose tissue
Creators: name: Biondi, Fiammetta <1987>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/04 Patologia generale

description: Aging is characterized by a chronic, low-grade inflammatory state called “inflammaging”. Mitochondria are the main source of reactive oxygen species (ROS), which trigger the production of pro-inflammatory molecules. We are interested in studying the age-related modifications of the mitochondrial DNA (mtDNA), which can be affected by the lifelong exposure to ROS and are responsible of mitochondrial dysfunction. Moreover, increasing evidences show that telomere shortening, naturally occurring with aging, is involved in mtDNA damage processes and thus in the pathogenesis of age-related disorders. Thus the primary aim of this thesis was the analysis of mtDNA copy number, deletion level and integrity in different-age human biopsies from liver, vastus lateralis skeletal muscle of healthy subjects and patients with limited mobility of lower limbs (LMLL), as well as adipose tissue. The telomere length and the expression of nuclear genes related to mitobiogenesis, fusion and fission, mitophagy, mitochondrial protein quality control system, hypoxia, production and protection from ROS were also evaluated. In liver the decrease in mtDNA integrity with age is accompanied with an increase in mtDNA copy number, suggesting the existence of a “compensatory mechanism” able to maintain the functionality of this organ. Different is the case of vastus lateralis muscle, where any “compensatory pathway” is activated and mtDNA integrity and copy number decrease with age, both in healthy subjects and in patients.  Interestingly,  mtDNA rearrangements do not incur in adipose tissue with advancing age. Finally, in all tissues a marked gender difference appears, suggesting that  aging and also gender diversely affect mtDNA rearrangements and telomere length in the three human tissues considered, likely depending on their different metabolic needs and  inflammatory status.
title: A Novel Approach for Reducing the Asymptotic Computational Complexity of Maximum Likelihood Multiuser Receivers in DS-CDMA Systems
Creators: name: Rizvi, Syed
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2005

description: Multiuser detection is a technique to improve the capacity and coverage in a code division multiple access (CDMA) system. Being a critical component of this technique, the maximum likelihood (ML) multiuser receiver has received extensive study. Multiuser detection is an important technology in wireless CDMA systems for improving both data rate as well as the user capacity. However, the computational complexity of this receiver prevents from the widespread use of this technique. Due to the high computational complexity, most of the CDMA systems today and in the near future will continue to use the conventional match filter with comparatively low user capacity and a slow data rate.

While many multiuser detectors could achieve optimal performance, they suffer from their relatively higher complexity that prevents CDMA systems to adapt this technology for signal detection. However, if we could lower the computational complexity of multiuser detectors, most of the CDMA systems would likely to get advantage of this technique in terms of increased system capacity and a better data rate. In this thesis, a novel approach for reducing the asymptotic computational complexity of multiuser receivers is proposed that utilizes the transformation matrix technique to improve the performance of multiuser detectors. By using the proposed algorithm, the computational complexity of multiuser detectors can be reduced by several orders of magnitude. This is done by realizing that much of the processing performed is unnecessary. Since most of the decisions are correct, we can reduce the number of computations by using the transformation matrixes only on those coordinates that are most likely lead to an incorrect decision. By doing this, we can greatly reduce the unnecessary processing that requires making a decision about the correct region or the coordinate. Thus, this reduction in the computational complexity would likely to give us a considerable improvement in the performance of multiuser receivers. The performance measure adopted in this thesis is the achievable bit rate for a fixed probability of error (10"7) and the consistent values of SNR.
Comparative Analysis of Phytochemical Profiles and Antioxidant Activities between Sweet and Sour Wampee (Clausena lansium) Fruits
Creators: name: Chang, Xiaoxiao
name: Ye, Yutong
name: Pan, Jianping
name: Lin, Zhixiong
name: Qiu, Jishui
name: Peng, Cheng
name: Guo, Xinbo
name: Lu, Yusheng
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: As a local medicine and food, wampee fruit, with abundant bioactive compounds, is loved by local residents in Southern China. Titratable acid (TA), total sugar (TS), and total phenolic and flavonoid contents were detected, and phytochemical profiles and cellular antioxidant activities were analyzed by the HPLC and CAA (cellular antioxidant activity) assay in five sweet wampee varieties and five sour wampee varieties. Results showed that the average TS/TA ratio of sweet wampee varieties was 29 times higher than sour wampee varieties, while TA content was 19 times lower than sour wampee varieties. There were much lower levels of total phenolics, flavonoids, and antioxidant activities in sweet wampee varieties than those in sour wampee varieties. Eight phytochemicals were detected in sour wampee varieties, including syringin, rutin, benzoic acid, 2-methoxycinnamic acid, kaempferol, hesperetin, nobiletin, and tangeretin, while just four of them were detected in sweet wampee varieties. Syringin was the only one that was detected in all the sour wampee varieties and was not detected in all sweet wampee varieties. Correlation analysis showed significant positive correlations between TA with phenolics, flavonoids, and total and cellular (PBS wash) antioxidant activities, while there were significant negative correlations between TS/TA with phenolic and cellular (no PBS wash) antioxidant activities. This suggested that the content of titratable acid in wampee fruit might have some relationship with the contents of phenolics and flavonoids. Sour wampee varieties should be paid much attention by breeders for their high phytochemical contents and antioxidant activities for cultivating germplasms with high health care efficacy.
Word Distinctivity - quantifying improvement of topic modeling results from n-gramming
Creators: name: P. Chai, Christine
Publisher: name: REVSTAT-Statistical Journal
Year: 2022

description: Text data cleaning is an important but often overlooked step in text mining because it is difficult to quantify the contribution. Therefore, we propose the word distinctivity to measure the improvement of topic modeling results from n-gramming, which preserves special phrases in a corpus. The word distinctivity evaluates the signal strength of a word’s topic assignments, and a high distinctivity means a high posterior proba[1]bility for the word to come from a certain topic. We implemented the latent Dirichlet allocation for topic modeling, and discovered that some special phrases show an increase in word distinctivity, reducing uncertainty in topic identification.
description: REVSTAT-Statistical Journal, Vol. 20 No. 2 (2022): REVSTAT-Statistical Journal
Safety, Security And safeguards In GEN IV sodium fast reactors
Creators: name: Rossi, Fabiana <1982>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: ING-IND/18 Fisica dei reattori nucleari

description: This work presents first a study of the national and international laws in the fields of safety, security and safeguards. The international treaties and the recommendations issued by the IAEA as well as the national regulations in force in France, the United States and Italy are analyzed. As a result of this, a comparison among them is presented. Given the interest of the Japan Atomic Energy Agency for the aspects of criminal penalties and monetary, also the Japanese case is analyzed.
The main part of this work was held at the JAEA in the field of proliferation resistance (PR) and physical protection (PP) of a GEN IV sodium fast reactor. For this purpose the design of the system is completed and the PR & PP methodology is applied to obtain data usable by designers for the improvement of the system itself. Due to the presence of sensitive data, not all the details can be disclosed. The reactor site of a hypothetical and commercial sodium-cooled fast neutron nuclear reactor system (SFR) is used as the target NES for the application of the methodology. The methodology is applied to all the PR and PP scenarios: diversion, misuse and breakout; theft and sabotage. The methodology is applied to the SFR to check if this system meets the target of PR and PP as described in the GIF goal; secondly, a comparison between the SFR and a LWR is performed to evaluate if and how it would be possible to improve the PR&PP of the SFR. The comparison is implemented according to the example development target: achieving PR&PP similar or superior to domestic and international ALWR. Three main actions were performed: implement the evaluation methodology; characterize the PR&PP for the nuclear energy system; identify recommendations for system designers through the  comparison.
Leveraging Parameter Efficient Training Methods for Low Resource Text Classification: A Case Study in Marathi
Creators: name: Deshmukh, Pranita
name: Kulkarni, Nikita
name: Kulkarni, Sanhita
name: Manghani, Kareena
name: Joshi, Raviraj
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: With the surge in digital content in low-resource languages, there is an escalating demand for advanced Natural Language Processing (NLP) techniques tailored to these languages. BERT (Bidirectional Encoder Representations from Transformers), serving as the foundational framework for numerous NLP architectures and language models, is increasingly employed for the development of low-resource NLP models. Parameter Efficient Fine-Tuning (PEFT) is a method for fine-tuning Large Language Models (LLMs) and reducing the training parameters to some extent to decrease the computational costs needed for training the model and achieve results comparable to a fully fine-tuned model. In this work, we present a study of PEFT methods for the Indic low-resource language Marathi. We conduct a comprehensive analysis of PEFT methods applied to various monolingual and multilingual Marathi BERT models. These approaches are evaluated on prominent text classification datasets like MahaSent, MahaHate, and MahaNews. The incorporation of PEFT techniques is demonstrated to significantly expedite the training speed of the models, addressing a critical aspect of model development and deployment. In this study, we explore Low-Rank Adaptation of Large Language Models (LoRA) and adapter methods for low-resource text classification. We show that these methods are competitive with full fine-tuning and can be used without loss in accuracy. This study contributes valuable insights into the effectiveness of Marathi BERT models, offering a foundation for the continued advancement of NLP capabilities in Marathi and similar Indic languages.
description: Accepted at I2CT 2024
Additional file 1 of Characteristics of people living with undiagnosed dementia: findings from the CFAS Wales study
Creators: name: Gamble, Laura D.
name: Matthews, Fiona E.
name: Jones, Ian R.
name: Hillman, Alex E.
name: Woods, Bob
name: Macleod, Catherine A.
name: Martyr, Anthony
name: Collins, Rachel
name: Pentecost, Claire
name: Rusted, Jennifer M.
name: Clare, Linda
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. Description of measures used in this study. Figure S1. Selection of those with diagnosed and undiagnosed dementia in CFAS Wales.
Additional file 2 of Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!
Creators: name: Petrenko, Aleksei Petrovich
name: Castelo-Branco, Camil
name: Marshalov, Dimitry Vasilevich
name: Kuligin, Alexander Valerievich
name: Shifman, Efim Munevich
name: Nesnova, Elena Sergeevna
name: Olegovna, Batsunova Mariia
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file 2: Table S2. Clinical and laboratory data according to the severity of ovarian hyperstimulation syndrome.
title: Bodenbewusstsein - darf es noch ein bisschen mehr sein?
title: Bodenbewusstsein - darf es noch ein bisschen mehr sein?
titleType: AlternativeTitle
Creators: name: Kruse, Klaus
name: Mathews, Jeanette
Publisher: name: My University
Year: 2020

description: Der in sehr langen Zeiträumen entstandener Boden ist eine kostbare und knappe Ressource, die unseres besonderen Schutzes bedarf. In den vergangenen Jahren fanden zahlreiche Aktionen und Aktivitäten statt, die darauf abzielten, den Boden stärker in das Blickfeld der Gesellschaft zu rücken. Gelungen ist dies vor allem durch das große, ungebrochene Engagement der unzähligen Akteure in den Behörden, Organisationen, Forschungseinrichtungen, Gremien und Verbänden. Das ändert aber nichts daran, dass Politik und Öffentlichkeit die stetig wachsenden Bodenbelastungen und Bodengefährdungen immer noch unzureichend wahrnehmen. Das belegen aktuelle Zahlen zur Flächenneuinanspruchnahme und zur Bodendegradation. Der Artikel setzt sich mit der Frage auseinander, wo wir heute im Ringen um mehr Bodenbewusstsein stehen. Auf welchen Erkenntnissen und Erfahrungen können wir aufbauen? Welche in den letzten Jahren entstandenen Werkzeuge und Instrumente können uns unterstützen? Wo gibt es wichtige Ansatzpunkte für die weitere Arbeit? © 2020 Erich Schmidt Verlag GmbH & Co. KG
description: Our soil, which has been formed over very long periods of time, is a precious and scarce resource that requires our special protection. In recent years there have been numerous actions and activities aimed at raising the profile of soil in society. This has been achieved through the unbroken commitment of countless members of various authorities, organisations, research institutions, committees and associations. This is contrasted by the fact that politicians and the public are still insufficiently aware of the increasing soil pollution and soil hazards. This is demonstrated by current figures on land reclaim and soil degradation. The article deals with the question where we stand today in the struggle for more soil awareness. What experiences can we build on? Which tools and instruments developed in recent years can support us? Where are important starting points for further work seen? © 2020 Erich Schmidt Verlag GmbH & Co. KG
Additional file 1 of Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!
Creators: name: Petrenko, Aleksei Petrovich
name: Castelo-Branco, Camil
name: Marshalov, Dimitry Vasilevich
name: Kuligin, Alexander Valerievich
name: Shifman, Efim Munevich
name: Nesnova, Elena Sergeevna
name: Olegovna, Batsunova Mariia
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file 1: Table S1. Baseline patients’ characteristics.
Current Practice and Barriers to Physiotherapists’ Use of Resistance Exercise for Older Adults in Acute Care
Creators: name: Chan, Amber
name: Hoens, Alison
name: Singh, C. A.
name: Elashi, Maha
name: Gerevas, K.
name: Idle, M
name: Lundie, J.
name: Urbina, M.
name: Pace, A.
name: Ma, Jasmin
Publisher: name: The University of British Columbia
Year: 2023

description: Purpose: The purpose of this cross-sectional study was to 1) describe the current use of resistance exercise (REx) and 2) identify barriers and facilitators for physiotherapists using REx among older adults in acute care. Methods: An online questionnaire measure guided by the Theoretical Domains Framework was distributed to physiotherapists across British Columbia (BC). Responses were scored on a five point Likert scale. Thematic analysis was used to code open text data from the questionnaire. Results: 105 physiotherapists (male=23, age 39.9±10.3 years, 12.4±10.3 years of experience) completed the questionnaire. Respondents reported frequently performing functional testing (95%) and assessing muscle strength (70%) in older adults, but few often prescribe REx to patients (34%). Prioritization of REx among other duties (2.62±1.02) and perceived poor patient motivation (2.97±0.88) were ranked among the greatest barriers. Open text data revealed physiotherapists felt some patients were unable to perform REx, they lacked a clear definition of REx, and sufficient support personnel. Conclusions: Addressing priorities, patient motivation, and providing resources may support physiotherapists to increase REx use, an important strategy for reducing the incidence of hospital associated deconditioning among older adults in the acute care setting.
Additional file 3 of Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!
Creators: name: Petrenko, Aleksei Petrovich
name: Castelo-Branco, Camil
name: Marshalov, Dimitry Vasilevich
name: Kuligin, Alexander Valerievich
name: Shifman, Efim Munevich
name: Nesnova, Elena Sergeevna
name: Olegovna, Batsunova Mariia
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file 3: Table S3. Anthropometric markers according to the degree of severity of the ovarian hyperstimulation syndrome.
Supplementary document for High-power, high-efficiency, all-fiberized-laser-pumped, sub-nanosecond, deep-UV laser at 260 nm - 5479583.pdf
Creators: name: Fu, Qiang
name: Hanrahan, Niall
name: Xu, Lin
name: Lane, Simon
name: Lin, Di
name: Jung, Yong-min
name: Mahajan, Sumeet
name: Richardson, David
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Technological trajectories and environmental policy: the transformation of the automobile
Creators: name: Barbieri, Nicolò <1985>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: SECS-P/01 Economia politica

description: This thesis aims to fill the gap in the literature by examining the relationship between technological trajectories and environmental policy in the automotive industry, focusing on the role of environmental policies in unlocking the industry from fossil fuel path-dependence. 
It first explores the inducement mechanism that underpins the interaction between environmental policy and green technological advances, investigating under what conditions the European environmental transport policy portfolio and the intrinsic characteristics of assignees' knowledge boost worldwide green patent production.
Subsequently, the thesis empirically analyses the dynamics of technological knowledge involved in technological trajectories assessing evolution patterns such as variation, selection and retention, in order to study the impact of policy implementation on technological knowledge related to electric and hybrid vehicle technologies. 
Finally, the thesis sheds light on the drivers that encourage a shift from incumbent internal combustion engine technologies towards low-emission vehicle technologies. This analysis tests whether tax-inclusive fuel prices and technological proximity between technological fields induce a shift from non-environmental inventions to environmentally friendly inventive activities and if they impact the competition between alternative vehicle technologies.
The findings provide insights into the effectiveness of environmental policy in triggering inventive activities related to the development of alternative vehicle technologies. In addition, there is evidence that environmental policy redirects technological efforts towards a sustainable path and impacts the competition between low-emission vehicles.
Valutazione dell'efficacia di methotrexate e sua influenza sui titoli anticorpali patogenetici nei pazienti affetti da pemfigoide bolloso
Evalutation of BP230 and of BP180-NC16a enzyme-linked
immunosorbent assay in the management of bullous pemphigoid
treated by low-dose methotrexate
Creators: name: Balestri, Riccardo <1980>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/35 Malattie cutanee e veneree

description: Studio osservazionale condotto presso la Dermatologia dell'Università di Bologna atto a valutare l'efficacia di methotrexate e, in particolare, la sua influenza sui titoli degli autoanticorpi patogeni nei pazienti affetti dalla malattia rara Pemfigoide Bolloso
description: Observational study to evaluate efficacy of methotrexate in bullous pemphigoid and in particular to evaluate the influence of methotrexate on the titres of pathogenic autoantibodies in patients affected by bullous pemphigoid
Asymptotics of the Adaptive Elastic Net Estimation for Conditional Heteroscedastic Time Series Models
Creators: name: Wang, Lihong
Publisher: name: REVSTAT-Statistical Journal
Year: 2022

description: In this paper we propose an iteratively reweighted adaptive elastic net estimation method for conditional heteroscedastic time series models. The sign consistency and the asymptotic normality of the estimator are investigated. Compared with the Lasso method, the elastic net is more efficient for autoregressive time series models, because it benefits not only from the selection of the Lasso but also from the grouping effect inherited from the ridge penalty. The Monte Carlo simulation studies based on an AR-ARCH model are reported to assess the finite-sample performance of the proposed elastic net method.
description: REVSTAT-Statistical Journal, Vol. 20 No. 2 (2022): REVSTAT-Statistical Journal
Preclinical development of anti-cancer strategies against human HER-2
Creators: name: Dall'Ora, Massimiliano <1983>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: MED/04 Patologia generale

description: HER-2 is a 185 kDa transmembrane receptor tyrosine kinase that belongs to the EGFR family. HER-2 is overexpressed in nearly 25% of human breast cancers and women with this subtype of breast cancer have a worse prognosis and frequently develop metastases. The progressive high number of HER-2-positive breast cancer patients with metastatic spread in the brain (up to half of women) has been attributed to the reduction in mortality, the effectiveness of Trastuzumab in killing metastatic cells in other organs and to its incapability to cross the blood-brain barrier. Apart from full-length-HER-2, a splice variant of HER-2 lacking exon 16 (here referred to as D16) was identified in human HER-2-positive breast cancers. 
Here, the contribution of HER-2 and D16 to mammary carcinogenesis was investigated in a model transgenic for both genes (F1 model). A dominant role of D16, especially in early stages of tumorigenesis, was suggested and the coexistence of heterogeneous levels of HER-2 and D16 in F1 tumors revealed the undeniable value of F1 strain as preclinical model of HER-2-positive breast cancer, closer resembling the human situation in respect to previous models.
The therapeutical efficacy of anti-HER-2 agents, targeting HER-2 receptor (Trastuzumab, Lapatinib, R-LM249) or signaling effectors (Dasatinib, UO126, NVP-BKM120), was investigated in models of local or advanced HER-2-positive breast cancer. In contrast with early studies, data herein collected suggested that the presence of D16 can predict a better response to Trastuzumab and other agents targeting HER-2 receptor or Src activity. Using a multiorgan HER-2-positive metastatic model, the efficacy of NVP-BKM120 (PI3K inhibitor) in blocking the growth of brain metastases and the oncolytic ability of R-LM249 (HER-2-retargeted HSV) to reach and destroy metastatic HER-2-positive cancer cells were shown.
Finally, exploiting the definition of “oncoantigen” given to HER-2, the immunopreventive activity of two vaccines on HER-2-positive mammary tumorigenesis was demonstrated.
Global and regional sea level variations in the recent past and future: insight from observations and modeling
Creators: name: Galassi, Gaia <1976>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: GEO/10 Geofisica della terra solida

description: This work is focused on the analysis of sea–level change (last century), based mainly on instrumental observations. During this period, individual components of sea–level change are investigated, both at global and regional scales. Some of the geophysical processes responsible for current sea-level change such as glacial isostatic adjustments and current melting terrestrial ice sources, have been modeled and compared with observations. A new value of global mean sea level change based of tide gauges observations has been independently assessed in 1.5 mm/year, using corrections for glacial isostatic adjustment obtained with different models as a criterion for the tide gauge selection. The long wavelength spatial variability of the main components of sea–level change has been investigated by means of traditional and new spectral methods. Complex non–linear trends and abrupt sea–level variations shown by tide gauges records have been addressed applying different approaches to regional case studies. The Ensemble Empirical Mode Decomposition technique has been used to analyse tide gauges records from the Adriatic Sea to ascertain the existence of cyclic sea-level variations. An Early Warning approach have been adopted to detect tipping points in sea–level records of North East Pacific and their relationship with oceanic modes. Global sea–level projections to year 2100 have been obtained by a semi-empirical approach based on the artificial neural network method. In addition, a model-based approach has been applied to the case of the Mediterranean Sea, obtaining sea-level projection to year 2050.
Priorities among effective clinical preventive services in British Columbia, Canada
Creators: name: Krueger, Hans
name: Robinson, Sylvia
name: Hancock, Trevor
name: Birtwhistle, Richard
name: Buxton, Jane A.
name: Henry, Bonnie
name: Scarr, Jennifer
name: Spinelli, John, 1955-
Publisher: name: BioMed Central
Year: 2022

description: Background Despite the long-standing experience of rating the evidence for clinical preventive services, the delivery of effective clinical preventive services in Canada and elsewhere is less than optimal. We outline an approach used in British Columbia to assist in determining which effective clinical preventive services are worth doing. Methods We calculated the clinically preventable burden and cost-effectiveness for 28 clinical preventive services that received a ‘strong or conditional (weak) recommendation for’ by the Canadian Task Force on Preventive Health Care or an ‘A’ or ‘B’ rating by the United States Preventive Services Task Force. Clinically preventable burden is the total quality adjusted life years that could be gained if the clinical preventive services were delivered at recommended intervals to a British Columbia birth cohort of 40,000 individuals over the years of life that the service is recommended. Cost-effectiveness is the net cost per quality adjusted life year gained. Results Clinical preventive services with the highest population impact and best value for money include services that address tobacco use in adolescents and adults, exclusive breastfeeding, and screening for hypertension and other cardiovascular disease risk factors followed by appropriate pharmaceutical treatment. In addition, alcohol misuse screening and brief counseling, one-time screening for hepatitis C virus infection in British Columbia adults born between 1945 and 1965, and screening for type 2 diabetes approach these high-value clinical preventive services. Conclusions These results enable policy makers to say with some confidence what preventive manoeuvres are worth doing but further work is required to determine the best way to deliver these services to all those eligible and to establish what supportive services are required. After all, if a clinical preventive service is worth doing, it is worth doing well.
Computational Approach Test for the Equality of Two Multivariate Normal Mean Vectors under Heterogeneity of Covariance Matrices
Creators: name: Gökpınar, Esra
name: Karanfil, Sezen
name: Ebegil, Meral
name: Arzu Ozdemir, Yaprak
name: Gökpınar, Fikri
Publisher: name: REVSTAT-Statistical Journal
Year: 2022

description: In this paper, a computational approach test (CAT) was proposed to test the equality of two multivariate normal mean vectors under heterogeneity of covariance matrices. The proposed test was compared with the other popular tests as well as their CAT versions in terms of estimated type I error rate and power. Simulation study shows that the proposed test and CAT versions of tests can be used as a good alternative test to test the equality of two multivariate normal mean vectors under heterogeneity of covariance matrices.
description: REVSTAT-Statistical Journal, Vol. 20 No. 2 (2022): REVSTAT-Statistical Journal
Microbial ecology of biotechnological processes
Creators: name: Fraraccio, Serena <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2015
Subjects: CHIM/11 Chimica e biotecnologia delle fermentazioni

description: The investigation of phylogenetic diversity and functionality of complex microbial communities in relation to changes in the environmental conditions represents a major challenge of microbial ecology research. Nowadays, particular attention is paid to microbial communities occurring at environmental sites contaminated by recalcitrant and toxic organic compounds. Extended research has evidenced that such communities evolve some metabolic abilities leading to the partial degradation or complete mineralization of the contaminants. Determination of such biodegradation potential can be the starting point for the development of cost effective biotechnological processes for the bioremediation of contaminated matrices. This work showed how metagenomics-based microbial ecology investigations supported the choice or the development of three different bioremediation strategies. First, PCR-DGGE and PCR-cloning approaches served the molecular characterization of microbial communities enriched through sequential development stages of an aerobic cometabolic process for the treatment of groundwater contaminated by chlorinated aliphatic hydrocarbons inside an immobilized-biomass packed bed bioreactor (PBR). In this case the analyses revealed homogeneous growth and structure of immobilized communities throughout the PBR and the occurrence of dominant microbial phylotypes of the genera Rhodococcus, Comamonas and Acidovorax, which probably drive the biodegradation process. The same molecular approaches were employed to characterize sludge microbial communities selected and enriched during the treatment of municipal wastewater coupled with the production of polyhydroxyalkanoates (PHA). Known PHA-accumulating microorganisms identified were affiliated with the genera Zooglea, Acidovorax and Hydrogenophaga. Finally, the molecular investigation concerned communities of polycyclic aromatic hydrocarbon (PAH) contaminated soil subjected to rhizoremediation with willow roots or fertilization-based treatments. The metabolic ability to biodegrade naphthalene, as a representative model for PAH, was assessed by means of stable isotope probing in combination with high-throughput sequencing analysis. The phylogenetic diversity of microbial populations able to derive carbon from naphthalene was evaluated as a function of the type of treatment.
Optimal Reinsurance of Dependent Risks
Creators: name: Bugalho De Moura, A.
name: Centeno, M.L.
Publisher: name: REVSTAT-Statistical Journal
Year: 2022

description: We analyse the problem of finding the optimal combination of quota-share and stop loss treaties, maximizing the expected utility or the adjustment coefficient of the cedent, for each of two risks dependent through a copula structure. By risk we mean a line of business or a portfolio of policies. Results are obtained numerically, using the software Mathematica. Sensitivity of the optimal reinsurance strategy to several factors are investigated, including: i) the dependence level, by means of the Kendall’s tau and the dependence parameter; ii) the type of dependence, using different copulas describing different tail behaviour; iii) the reinsurance calculation principles, where expected value, variance and standard deviation principles are considered. Results show that different dependence structures, yield significantly different optimal solutions. The optimal treaty is also very sensible to the reinsurance premium calculation principle. Namely, for variance related premiums the optimal solution is not the pure stop loss. In general, the maximum adjustment coefficient decreases when dependence increases.
description: REVSTAT-Statistical Journal, Vol. 20 No. 2 (2022): REVSTAT-Statistical Journal
The unprecedented Pacific Northwest heatwave of June 2021
Creators: name: White, Rachel
name: Anderson, Sam
name: Booth, James
name: Braich, Ginni
name: Draeger, Christina
name: Fei, Cuiyi
name: Harley, Christopher David Grant
name: Henderson, Sarah B.
name: Jakob, Matthias, 1966-
name: Lau, Carie-Ann
name: Admasu, Lualawi Mareshet
name: Narinesignh, Veeshan
name: Rodell, Christopher
name: Roocroft, Eliott
name: Weinberger, Kate
name: West, Greg
Publisher: name: The University of British Columbia
Year: 2022

description: In late June to early July 2021 a heatwave of unprecedented magnitude impacted the Pacific Northwest region, lands colonially named British Columbia (BC) and Alberta (AB) in Canada, and Washington (WA) and Oregon (OR) in the United States. Many locations broke all-time maximum daily temperature records by more than 5°C. The standing Canadian national temperature record was broken on three consecutive days, at multiple locations, with the highest temperature of 49.6°C recorded, 4.6°C higher than the previous Canadian record. Weather forecasts provided advanced notice of the severity of the event, while sub-seasonal forecasts showed substantially increased likelihood of atmospheric blocking and high temperatures with 10-day lead times, and some skill out to 18 days. The impacts of this event were catastrophic. Estimates indicate at least 900 attributable deaths occurred across BC, WA and OR, likely the deadliest weather event in Canadian1 history. The heat contributed to mass-mortalities of marine life, reduced crop and fruit yields, river flooding from rapid snow and glacier melt, and a rapid increase in wildfires—the latter contributing to devastating landslides in the months following.