cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Rock-uplift history of the Central Pontides from river-profile inversions and implications for the evolution of the North Anatolian Fault
Creators: name: Racano, Simone
name: Schildgen, Taylor
name: Ballato, Paolo
name: Yıldırım, Cengiz
name: Wittmann, Hella
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Major strike-slip fault systems on Earth, like the North Anatolian Fault (NAF), play an important role in accommodating plate motion, but little is known about their spatiotemporal evolution. In the Central Pontides, north of the central segment of the NAF, data from thermochronology suggest an exhumation phase occurred after 11 Myr. However, the precise onset of this uplift phase is poorly constrained. In this study, we define the spatiotemporal rock-uplift pattern within the Central Pontides over the last ~10 Myr by performing linear inversions of 19 river profiles draining the northern margin of the Central Pontides, from the Sinop Range to the Black Sea. We use 21 new 10Be-derived basin-average denudation rates to calibrate an erodibility parameter, necessary to infer rock-uplift histories from χ-transformed river profiles. Our results document an increase in rock-uplift rates after 10 Ma, with peaks of 0.15–0.25 km/Myr occurring between 4 and 2 Ma. Moreover, the spatiotemporal uplift variations suggest that rock uplift migrated westward over a period of 2–2.5 Myr. Linking the uplift to the transpression produced along the NAF central segment, we used the faster uplift onset to calculate the NAF propagation rate, estimated to be ~74±13 km/Myr. Combining our results with those from previous studies on the NAF age, we found differences in fault-propagation rates that coincide with differences in the orientation of the NAF relative to plate-convergence vectors. Fault segments with higher obliquity appear to have propagated at rates up to 2-fold slower than those oriented parallel to the plate-convergence vector.
Beyond resource selection: emergent spatio-temporal distributions from animal movements and stigmergent interactions
Creators: Jonathan R. Potts
Valeria Giunta
Mark A. Lewis
Publisher: name: University of Alberta Library
Year: 2022

A principal concern of ecological research is to unveil the causes behind observed spatiotemporal distributions of species. A key tactic is to correlate observed locations with environmental features, in the form of resource selection functions or other correlative species distribution models. In reality, however, the distribution of any population both affects and is affected by those surrounding it, creating a complex network of feedbacks causing emergent spatio-temporal features that may not correlate with any particular aspect of the underlying environment. Here, we study the way in which the movements of populations in response to one another can affect the spatio-temporal distributions of ecosystems. We construct a stochastic individual-based modelling (IBM) framework, based on stigmergent interactions (i.e. organisms leave marks which cause others to alter their movements) between and within populations. We show how to gain insight into this IBM via mathematical analysis of a partial differential equation (PDE) system given by a continuum limit. We show how the combination of stochastic simulations of the IBM and mathematical analysis of PDEs can be used to categorise emergent patterns into homogeneous vs. heterogeneous, stationary vs. perpetually-fluctuating, and aggregation vs. segregation. In doing so, we develop techniques for understanding spatial bifurcations in stochastic IBMs, grounded in mathematical analysis. Finally, we demonstrate through a simple example how the interplay between environmental features and between-population stigmergent interactions can give rise to predicted spatial distributions that are quite different to those predicted purely by accounting for environmental covariates.
Additional file 1 of NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits
Creators: name: Li, Ziyi
name: Vidjro, Olivia Ewi
name: Guo, Gengni
name: Du, Yanfeng
name: Zhou, Yao
name: Xie, Qian
name: Li, Jiaxin
name: Gao, Keqiang
name: Zhou, Li
name: Ma, Tengfei
Publisher: name: figshare
Year: 2023
Subjects: Biochemistry
Medicine
Neuroscience
Pharmacology
Biotechnology
Mental Health

description: Additional file 1: Fig. S1. The expression of NLRP3 and GAPDH. Fig. S2. Genotyping of NLRP3 KO mice. Fig. S3. Measurement of total distance and anxiety-like behavior in experimental and control groups. Fig. S4. The expression of caspase-1 and GAPDH in mPFC. Fig. S5. The expression of Caspase-1 and GAPDH in striatum. Fig. S6. The identification of genotype difference between wild-type and NLPR3 KO control mice in Nissl staining and Western blotting tests. Fig. S7. The difference of PPR and NMDAR/AMPAR ratio between WT and NLRP3 KO control group. Fig. S8. Optogenetic induction of LTD in corticostriatal glutamatergic transmission prevented alcohol withdrawal anxiety-like behavior. Fig. S9. Measurement of total distance and anxiety-like behavior of groups of mice as control in optogenetic LTP and LTD experiments.
NCEI Promotional Materials
Creators: name: Ritchie, Nancy
Publisher: name: ESIP
Year: 2021
Subjects: subject: Atmospheric Sciences
subject: FOS: Earth and related environmental sciences
subject: Oceanography
subject: Hydrology

description: A list of data resources provided by the National Center for Environmental Information (NCEI) for the 2021 AMS Data Help Desk.
How does mode of travel affect risks posed to other road users? An analysis of English road fatality data, incorporating gender and road type
Creators: name: Aldred, Rachel
name: Johnson, Rob
name: Jackson, Christopher
name: Woodcock, James
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
1612
bicycle
motor vehicle occupant
pedestrian
cross sectional study
passenger
driver

description: Background: Most analysis of road injuries examines the risk experienced by people using different modes of transport, for instance, pedestrian fatalities per-head or per-km. A small but growing field analyses the impact that the use of different transport modes has on other road users, for instance, injuries to others per-km driven. Methods: This paper moves the analysis of risk posed to others forward by comparing six different vehicular modes, separating road types (major vs minor roads in urban vs rural settings). The comparison of risk posed by men and women for all these modes is also novel. Results: Per-vehicle kilometre, buses and lorries pose much the highest risk to others, while cycles pose the lowest. Motorcycles pose a substantially higher per-km risk to others than cars. The fatality risk posed by cars or vans to ORUs per km is higher in rural areas. Risk posed is generally higher on major roads, although not in the case of lorries, suggesting a link to higher speeds. Men pose higher per-km risk to others than women for all modes except buses, as well as being over-represented among users of the most dangerous vehicles. Conclusions: Future research should examine more settings, adjust for spatial and temporal confounders, or examine how infrastructure or route characteristics affect risk posed to others. Although for most victims the other vehicle involved is a car, results suggest policy-makers should also seek to reduce disproportionate risks posed by the more dangerous vehicles, for instance, by discouraging motorcycling. Finally, given higher risk posed to others by men across five of six modes analysed, policy-makers should consider how to reduce persistent large gender imbalances in jobs involving driving.
title: Deep-stuck Ti-rich carbonatites: A link to the composition of primitive carbonatite melts?
Creators: name: Giebel, R. Johannes
name: Walter, Benjamin F.
name: Marks, Michael A.W.
name: Markl, Gregor
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Carbonatitic melts are subject to different processes during their ascent (e.g., fractional crystallization and crustal contamination), which may cause a strong change in their composition. Their original composition has not been definitively determined. In order to find indications of the primitive composition, it appears reasonable to investigate the deepest known carbonatite occurrences. One of the deepest known carbonatites is the Palabora complex in South Africa. Most of the complex is represented by varieties of pyroxenite, while the center of the complex comprises a multiple calcite carbonatite intrusion (called Loolekop). A new discovery of a second carbonatite in the southern part of the complex, reveals a head section of a stuck carbonatite intrusion, which is reflected by isolated veins on the surface and a more extensive abundance with depth. This carbonatite shows a strong enrichment in Ti (>10 wt.% TiO2) with up to 20 modal% ilmenite. Fenitising fluids exsolved from the carbonatitic melt have even titanitised the surrounding pyroxenite. Additionally, previous investigations of the Loolekop show that the Ti content of the carbonatite increases systematically from the center of the intrusion to the margin. This could indicate a noticeably higher Ti content in the more primitive melt that crystallized in the marginal areas in comparison to a slightly more evolved melt that formed the center. Could this be an indication that primitive carbonatite melts are rich in titanium and lose the titanium rapidly during their evolution?
Map #28, Site 5MT2037, Arbitrary Unit 105 , Arbitrary Unit 107, and Arbitrary Unit 108, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2019
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: Pueblo III
valueUri: https://core.tdar.org/browse/temporal-keyword/56/pueblo-iii
subject: 5MT2037
valueUri: https://core.tdar.org/browse/site-name/118042/5mt2037
subject: Pasquin Site
valueUri: https://core.tdar.org/browse/site-name/118041/pasquin-site

description: Site 5MT2037, Arbitrary Unit 105 , Arbitrary Unit 107, and Arbitrary Unit 108, Stratigraphic Profile
title: Earth systems education - Four decades of Research-Development-Implementation
Creators: name: Orion, Nir
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
This presentation describes the milestones of four decades of Earth Science Education (ESE) research. It will describe the evolution of the ESE Group in the Department of Science Teaching at the Weizmann Institute of Science, Israel. This evolution is derived from dozens of quantitative and qualitative studies and channeled into the holistic earth systems educational approach that incorporates integration of the outdoor learning environment as a central component of the learning sequence, a model for the integration of learning environments, the development of environmental insight through a holistic earth systems approach; development of a layered systems thinking model; and the notion of learning as an instinct. Integration of these components led to the development of the learning instinct theory, which contradicts the essentialist–reductionist paradigm, which still dominates universities and schools worldwide.

The holistic Earth systems approach is an effective platform for developing environmental insight. However, the low status of ESE in schools worldwide prevents the educational treatment needed to reduce environmental crises. Thus, climate change is an educational crisis. It results from the continuing failure of the environmental education paradigm that ignores the Earth systems and environmental insight approach.

The climate crisis should have been a turning point in raising the awareness of Earth Sciences as a scientific discipline and the importance of raising the profile of Earth science teaching in schools.

The academic geoscience community is a keystone for bridging the disturbing gap between the importance of Earth science to humanity and its low profile in schools worldwide.
Characterization study of Si HVeV detectors through analysis of charge spectra
Creators: name: Musaab, Al-Bakry
Publisher: name: University of British Columbia
Year: 2023

description: In the pursuit of directly detecting Dark Matter (DM), the SuperCDMS experiment, situated at the SNOLAB facility in Canada, focuses on studying two primary types of detectors for use in the main experiment: iZIP and HV detectors. In this analysis, we examine a specific type of detector known as High Voltage eV-resolution (HVeV) detectors. These detectors are smaller in size and offer superior resolution compared to HV detectors. The HVeV detector consists of high-purity silicon operating at low temperatures and uses the Neganov-Trofimov-Luke (NTL) effect to convert the signals of electron/hole pairs created by energy deposition into detectable phonon energy, which is measured using transition edge sensors on the surfaces of the detector. An integral part of studying HVeV detectors involves investigating the probabilities of Charge Trapping (CT), in which charge carriers are lost without receiving the full NTL amplification, and Impact Ionization (II), in which charge carriers dislodged from impurities in the crystal contribute additional photon energy through the NTL effect. Measurements of a prototype HVeV detector at TRIUMF reveal a CT probability of (12.0 ± 0.2)% and an II probability of (1.4 ± 0.2)%. A notable observation is the strong correlation between the intensity of the calibration LED and both the position of the spectrum peak and the detector resolution. We propose an explanation for this effect: the presence of non-quantized energy deposition due to photons that are absorbed without NTL amplification. We develop a model and provide substantial evidence to support this hypothesis. Lastly, we discuss the implications of this effect on calibration in previous SuperCDMS runs, highlighting the potential consequences it may have.
title:   Self-Advocacy Training for Students with Complex Communication Needs using Time Delay and Generative Learning
Creators: name: Patterson, Alexis Rai
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: classificationCode: 5.3
subject: FOS: Educational sciences

description: Employers seek employees with communicative competence in various vocational environments. Communicative competence is created through socio-linguistic skills such as self-advocacy and self-determination skills. This study examined communicative competence for individuals with complex communication needs within a vocational environment. Generalization of skills across environments is imperative for skill development for individuals with disabilities. This study also examined the use of generalization of skills with using generative learning.
description: © 2023 Alexis Rai Patterson
Cooked, Unextracted Soybean Meal, Its Economic Feasibility in Poultry Feeds (Preliminary Report)
Creators: name: Poats, F. J.
name: Doty, H. O.
name: Eley, C. P.
name: Poats, F. J.
name: Doty, H. O.
name: Eley, C. P.
Publisher: name: Unknown
Year: 1961
Subjects: Crop Production/Industries
Livestock Production/Industries
Production Economics
Research and Development/Tech Change/Emerging Technologies

description: Excerpts from the Introduction: Feeding tests with poultry have shown that beneficial results can be obtained by an ingredient change in mixed feeds. In place of soybean oil meal and an added "inedible" fat in the ration, cooked unextracted soybean meal can be used. This finding opens the door for consideration of direct conversion of soybeans to feed mixing uses by feed mills or other feed processors. Economic questions of feasibility of processing soybeans this new way need to be resolved. A feed mixer or other processor of cooked unextracted soybean meal needs the means of deciding which is cheaper, tallow or grease added to a feed mix with soybean meal, or soybeans plus the cost of processing them this new way. This study was made to obtain preliminary evaluations of the various factors influencing this economic decision. A satisfactory commercial process for producing cooked unextracted soybean meal has not been completely worked out. Equipment manufacturers need to design equipment with processing costs per unit within the potential margins allowable. Economic research is needed to bridge the gap between nutrition research findings on cooked unextracted soybean meal as a poultry feed ingredient and commercial adoption of the product. Possible users of such new equipment need a guide as to the potential for profit it offers.
title: TETRAPODS FROM THE GERMAN BUNTSANDSTEIN (TRIASSIC: OLENEKIAN-ANISIAN): EVIDENCE ON TETRAPOD DIVERSIFICATION IN LAURASIA FOLLOWING THE END-PERMIAN EXTINCTION
Creators: name: Schoch, Rainer R
name: Sues, Hans-Dieter
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Following the end-Permian biotic crisis, reptiles rapidly diversified and dispersed across the globe at the beginning of the Triassic Period. Non-mammalian synapsids became much less abundant and had massive losses in diversity during the end-Permian event. To date, the fossil record of continental tetrapods has largely been restricted to the Karoo of South Africa and European Russia. In the Central European Basin, Early and early Middle Triassic continental red beds are collectively referred to as the Buntsandstein Group. Whereas the strata of the Lower Buntsandstein are largely unfossiliferous, those of the Middle and Upper Buntsandstein have yielded many tracks and trackways representing a great diversity of tetrapods and occasionally skeletal remains of tetrapods. Temnospondyl stem-amphibians were common with a variety of ecomorphs. A sandstone quarry at Rotfelden in the Black Forest region (Germany) exposed a 6-to-8-m-thick section within the top of the Röt 4 Subformation. Tetrapod remains have been recovered from several horizons in this section. Previously, Amotosaurus rotfeldensis, a tanystropheid archosauromorph and the temnospondyl Eocyclotosaurus lehmani have been reported from this locality. New discoveries include a new Euparkeria-grade archosauriform and a rhynchosaur. The latter is documented by a group of three juvenile skeletons. The absence of unambiguous records of non-mammalian synapsids in the Buntsandstein is possibly related to environmental factors. The growing number of tetrapod taxa from the Buntsandstein suggests that assemblages of continental tetrapods had already recovered to a considerable extent 6-7 million years after the end-Permian extinction.
title: Using Laser-Diffraction Grain-Size Analysis and End-Member Modelling Analysis (EMMA) to understand laminar to turbulent flow transitions in deep-water systems
Creators: name: Brooks, Hannah Louise
name: Spychala, Yvonne Therese
name: Steel, Elisabeth
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Hybrid beds or linked debrites are deposits that form under bi- or tri-partite flow conditions, involving transitions from turbulent to laminar flow conditions. Often, hybrid beds occur with distal or lateral flow transformation following significant entrainment of a muddy substrate and/or declining turbulent energy. Hybrid beds have been noted to make up significant proportions of deposits within basin-floor setting worldwide, most commonly within the distal fringes of lobe systems. The stratigraphic distribution of hybrid beds has been linked to the character of the supply slope and seafloor relief, where hybrid beds are invoked to develop during periods of disequilibrium in out-of-grade slopes.

The mechanisms of formation and evolution of flows that deposit hybrid beds have been significantly studied and debated over the past decades. The aim of this study is to utilize techniques not commonly used in this area, namely Laser-Diffraction Grain-Size Analysis and End-Member Modelling Analysis (EMMA) to undertake a detailed study of lateral and down-dip changes within targeted deposits, to interpret more accurately how and when turbulent to laminar fluctuations occur, as well as adding quantitative analysis to previously established qualitative models. Samples were taken from the Marnoso-Arenacea Formation, the Castagnola Formation, and the Gottero Formation.

Initial findings show significant correlation between grain-size distribution from similar facies across different formations. Despite variability in the median grain-size between formations, similar end members can be extracted from each, indicating deposition under similar flow conditions.
Map #411, Site 5MT10647, Nonstructure 108, Arbitrary Unit 107, and Arbitrary Unit 112, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Nonstructure 108, Arbitrary Unit 107, and Arbitrary Unit 112, Stratigraphic Profile
Ophthalmology of clinically normal alpacas ( Vicugna pacos ) in the United Kingdom: a cross-sectional study
Creators: name: Faulkner, Josephine
name: Williams, David Leonard
name: Mueller, Karin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
Ophthalmology
Eyes
Camelids
Alpacas

description: Background: Alpacas are being more frequently presented to veterinarians in the UK. It is important to validate whether published normal ocular parameters are consistent with the alpaca population in the UK. Methods: Ophthalmic examinations were performed on healthy alpacas (Vicugna pacos) from three farms in East Anglia, UK. Results: On direct ophthalmoscopy of 35 alpacas, there was a 50 per cent prevalence of opacities within the lens in alpacas older than two years old (n=8/16). There was a 36.8 per cent prevalence of persistent hyaloid arteries in alpacas under two years old (n=7/19). The mean Schirmer tear test-1 value was 20.0 ±6 mm/minute (n=40). The mean intraocular pressure measured by rebound tonometry was 17.2 ±5.5 mmHg (n=46), and applanation tonometry resulted in statistically similar values (P=0.30; n=25). There was a significant variation in intraocular pressure throughout a 24-hour period (n=8). Fluorescein dye was not detected at the nostrils of any of the alpacas which underwent a Jones test to assess nasolacrimal duct patency (n=8). Conclusion: The ophthalmic findings appear largely consistent with previously published values from North America and continental Europe. Variations include the large range of measurements obtained and evidence of diurnal variation in intraocular pressure.
title: Seafloor geology and the European EMODnet data infrastructure: The challenge of integrating off-shore data across EEZ boundaries
Creators: name: Asch, Kristine Eva Charlotte
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Within the EMODnet Geology project BGR is leading the Workpackage Seafloor geology with the aim to compile and harmonise data of the pre-Quaternary and Quaternary off-shore geology and geomorphology of the European Seas, and finally publish the results according to FAIR data principles. The data are assembled from 36 EMODnet Geology partner organisations and derived mostly from geophysical surveys (e.g. echo soundings) and sampling (e.g. drilling or dredging). Major challenges pose the heterogeneity of the provided data regarding terminology, geometry, level of detail, age of  datasets and technical conditions:

terminology. The participating partners use their own national or regional classification systems and description;

geometry: artificial discrepancies at EEZ-boundaries;

scale: some regions are investigated in comparatively high detail while others are mapped in overview scales;

age: often recently mapped units need to be integrated with data resulting from earlier mapping campaigns;

heterogeneous technical conditions within partner organisations.

In order to ensure data interoperability and create the maps layers in a largely harmonized, unified manner, the project requires common standards e.g.

controlled vocabularies, optimally based on existing standards such as INSPIRE or CGI-GeoSciML terminology,

a straightforward data model and

a pragmatic approach that takes into account the realities of the project partners.

This presentation will demonstrate the methodological approach to collate and combine data, information and knowledge from over 30 international partners and the challenge to develop, integrate and publish largely harmonized map layers of the off-shore geology of Europe and beyond.
title: Early Jurassic K-Ar illite age data of fault gouge from a reverse fault of the Gernsbach-Neuenbürg flexure in crystalline basement rocks of the Nordschwarzwald (SW Germany)
Creators: name: Grimmer, Jens Carsten
name: Wemmer, Klaus
name: Hueck, Mathias
name: Kley, Jonas
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
We investigated a SSE-dipping reverse fault zone of the ENE-striking Gernsbach-Neuenbürg flexure within c. 325 Ma old coarse grained two-mica granite. The fault zone consists of a hematized, cataclastic 15-20 cm thick, damage zone, predominantly developed in the hanging wall, and a c. 1 cm thick greyish-greenish clay-rich fault core. We took two gouge samples, spaced c. 1 m apart from each other.

Both samples were fractionated into three grain sizes (<0.2 µm, <2 µm and 2-6 µm), all of which yielded ages between 198 Ma and 171 Ma. The fact that these ages are much younger than the age of the faulted host rock, and that both samples exhibit variations between the different fractions of a few tens of Myr at most, indicates efficient authigenic clay growth. This authigenic crystallization probably occurred between 200 °C and 300 °C, based on the illite “crystallinity” Index and the predominance of the 2M1 illite polytype in the samples.

The Gernsbach-Neuenbürg flexure plunges to the ENE beneath deformed Triassic strata of the ENE-striking, c. 100 km long „Neckar-Jagst-Furche“, which is yet kinematically poorly understood. Its large strike length and apparent low bulk displacements are consistent with reactivation of the southern boundary fault zone of the Permocarboniferous Kraichgau basin as suggested by mapping of the Gernsbach-Neuenbürg flexure. The widespread Jurassic radiometric age data in southern Germany indicate major hydrothermal activity and a structurally complex, yet poorly resolved, deformation pattern, most likely associated with oblique rifting that developed into formation of the North Penninic ocean.
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL- lpr mice
Creators: name: Fortner, Karen A
name: Blanco, Luz P
name: Buskiewicz, Iwona
name: Huang, Nick
name: Gibson, Pamela C
name: Cook, Deborah L
name: Pedersen, Hege L
name: Yuen, Peter S T
name: Murphy, Michael P
name: Perl, Andreas
name: Kaplan, Mariana J
name: Budd, Ralph C
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Animal models
1506
2252
autoimmune diseases
systemic lupus erythematosus
T cells
inflammation

description: Funder: Central New York Community Foundation; FundRef: http://dx.doi.org/10.13039/100001026
description: Objectives: Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen species (mROS) in T cells and neutrophils. This can provoke numerous cellular changes including oxidation of nucleic acids, proteins, lipids and even induction of cell death. We have previously observed that in T cells from patients with lupus, the increased mROS is capable of provoking oligomerisation of mitochondrial antiviral stimulator (MAVS) and production of type I interferon (IFN-I). mROS in SLE neutrophils also promotes the formation of neutrophil extracellular traps (NETs), which are increased in lupus and implicated in renal damage. As a result, in addition to traditional immunosuppression, more comprehensive treatments for lupus may also include non-immune therapy, such as antioxidants. Methods: Lupus-prone MRL-lpr mice were treated from weaning for 11 weeks with the mitochondria-targeted antioxidant, MitoQ (200 µM) in drinking water. Mice were then assessed for ROS production in neutrophils, NET formation, MAVS oligomerisation, serum IFN-I, autoantibody production and renal function. Results: MitoQ-treated mice manifested reduced neutrophil ROS and NET formation, decreased MAVS oligomerisation and serum IFN-I, and reduced immune complex formation in kidneys, despite no change in serum autoantibody . Conclusions: These findings reveal the potential utility of targeting mROS in addition to traditional immunosuppressive therapy for lupus.
title: Quantitative mineralogical analysis for the development of new exploration vectors at the Spremberg-Graustein-Schleife Cu-Ag Kupferschiefer deposit, Lusatia, Germany
Creators: name: Kim, Yonghwi
name: Frenzel, Max
name: Guy, Bradley Martin
name: Thiele, Samuel Thomas
name: Gutzmer, Jens
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The Spremberg-Graustein-Schleife deposit is part of the Kupferschiefer district in the southern Permian Basin and comprises copper and silver mineralized rocks hosted by pre-Zechstein sandstones, Kupferschiefer, and Zechstein carbonates. As there is still significant exploration potential across the southern Permian basin, the goal of the present study is to identify mineralogical signatures, which may be usable as exploration vectors. The specific focus in this study is on the gangue mineralogy, since it is more likely to provide a larger detectable footprint in the mineralizing system.

Multiple analytical methods were combined to investigate samples from three mineralized and non-mineralized drill-cores. Scanning Electron Microscope (SEM) based image analysis (MLA) was carried out to obtain quantitative data on mineralogy as well as major-element carbonate chemistry of each stratigraphic unit. Quantitative bulk-powder XRD was performed as an external validation. In addition, the SEM-MLA data are being integrated with hyperspectral core-scans for upscaling observations.

Zechstein carbonate rocks in the well-mineralized drill-hole are dominantly composed of dolomite, in contrast to the weakly-mineralized drill-hole that contains more calcite. In the mineralized sandstones, three successive generations of carbonate cement have been identified from backscatter electron imaging and semi-quantitative EDX measurements, comprising i) dolomite to ii) Mn-Fe dolomite, and finally the deposition of iii) ankerite rims. Kaolinite, one of the main cement minerals in the sandstones, appears more abundantly in the mineralized than in the barren sandstones. The occurrence of ankerite and kaolinite may indicate overprinting by the mineralizing fluids and may thus be useable vectors towards mineralization.
Rana esculenta L. 1758
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Ranidae
Rana
Rana esculenta

description: Rana esculenta L.
Ueberwinterte Larve v. H. Prof. Kollmann (Neudorf).
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 670, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
Map #33, Site 5MT10736, Arbitrary Unit 101 and Arbitrary Unit 106, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: TJ Smith Site
valueUri: https://core.tdar.org/browse/site-name/118014/tj-smith-site
subject: 5MT10736
valueUri: https://core.tdar.org/browse/site-name/118015/5mt10736

description: Site 5MT10736, Arbitrary Unit 101 and Arbitrary Unit 106, Stratigraphic Profile
title: SHmax orientation in the Alpine region from stress-induced anisotropy in nonlinear elasticity derived from ambient noise correlations
Creators: name: Aiman, Yongki Andita
name: Delorey, Andrew
name: Lu, Yang
name: Bokelmann, Götz
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Major faults such as the Periadriatic Fault and the Giudicarie Fault have been active in the past, and they have even been central features of the larger-scale deformation in the Alps. It seems that these faults are not active anymore though and we investigate why this is so by inspecting the orientation of the regional stress field which loads the faults mechanically. The orientation of maximum horizontal compressive stress (SHmax) is commonly estimated from in-situ borehole breakouts and earthquake focal mechanisms. Borehole measurements are expensive, and therefore sparse, and earthquake measurements can only be made in regions with many well-characterized earthquakes. Here we derive the stress-field orientation using stress-induced anisotropy in nonlinear elasticity. We measure the strain derivative of velocity as a function of azimuth. We use a natural pump-probe approach which consists of measuring elastic wave speed using empirical Green’s functions (probe) at different points of the earth tidal strain cycle (pump). The approach is validated using a larger data set in the Northern Alpine Foreland region where the orientation of SHmax is known from borehole breakouts. The technique is then applied to the Southern Alps to understand the contemporary stress pattern associated with the ongoing deformation due to the counterclockwise rotation of the Adriatic plate with respect to the European plate. Our results explain why the two major faults in Northeastern Italy, the Giudicarie Fault and the Periadriatic Line (Pustertal-Gailtal Fault) are currently inactive, while the currently acting stress field allows faults in Slovenia to deform actively.
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel
Creators: name: Din, Shahida
name: Kent, Alexandra
name: Pollok, Richard C
name: Meade, Susanna
name: Kennedy, Nicholas A
name: Arnott, Ian
name: Beattie, R Mark
name: Chua, Felix
name: Cooney, Rachel
name: Dart, Robin J
name: Galloway, James
name: Gaya, Daniel R
name: Ghosh, Subrata
name: Griffiths, Mark
name: Hancock, Laura
name: Hansen, Richard
name: Hart, Ailsa
name: Lamb, Christopher Andrew
name: Lees, Charlie W
name: Limdi, Jimmy K
name: Lindsay, James O
name: Patel, Kamal
name: Powell, Nick
name: Murray, Charles D
name: Probert, Chris
name: Raine, Tim
name: Selinger, Christian
name: Sebastian, Shaji
name: Smith, Philip J
name: Tozer, Phil
name: Ustianowski, Andrew
name: Younge, Lisa
name: Samaan, Mark A
name: Irving, Peter M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Inflammatory bowel disease
1506
2474
2312
ulcerative colitis
clinical decision making
IBD clinical

description: Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines as a reference point. Design: We convened a RAND appropriateness panel comprising 14 gastroenterologists and an IBD nurse consultant supplemented by surgical and COVID-19 experts. Panellists rated the appropriateness of interventions for ASUC in the context of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Median scores and disagreement index (DI) were calculated. Results were discussed at a moderated meeting prior to a second survey. Results: Panellists recommended that patients with ASUC should be isolated throughout their hospital stay and should have a SARS-CoV-2 swab performed on admission. Patients with a positive swab should be discussed with COVID-19 specialists. As per BSG guidance, intravenous hydrocortisone was considered appropriate as initial management; only in patients with COVID-19 pneumonia was its use deemed uncertain. In patients requiring rescue therapy, infliximab with continuing steroids was recommended. Delaying colectomy because of COVID-19 was deemed inappropriate. Steroid tapering as per BSG guidance was deemed appropriate for all patients apart from those with COVID-19 pneumonia in whom a 4–6 week taper was preferred. Post-ASUC maintenance therapy was dependent on SARS-CoV-2 status but, in general, biologics were more likely to be deemed appropriate than azathioprine or tofacitinib. Panellists deemed prophylactic anticoagulation postdischarge to be appropriate in patients with a positive SARS-CoV-2 swab. Conclusion: We have suggested COVID-19-specific adaptations to the BSG ASUC guideline using a RAND panel.
Expanding connectivity between documents structures and bioactivity
Creators: name: Southan, Christopher
Publisher: name: Zenodo
Year: 2023

description: Presented on 4th of May 2023 as part of the Elsevier Life Sciences Webinar series (a recording of both presentations should become available for webinar registrants). This webinar addresses the landscape of bioactivity databases and discusses how addressing bio-curation and data sharing challenges can accelerate medicinal chemistry research. To achieve this, the community needs to increase the outward flow of experimental results locked-up in millions of published PDFs into structured open databases that explicitly capture the connectivity between structures, documents, and bioactivity results
Characteristics analysis of moon-based earth observation under the ellipsoid model
Creators: name: Liu, Guang
name: Huadong Guo
name: Hanssen, Ramon F.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Using the Moon as an Earth observation platform for remote sensing offers the benefits of a high orbital altitude and vast surface area, which could provide continuous Earth observation capabilities over great temporal and spatial scales. Over the course of China’s follow-up lunar missions in the next three Five-year plans, the Earth observation instruments will be put on the Moon. However, the understanding of the characteristics of Moon-based Earth observations remains limited. Here, the observational characteristics for a moon-based platform related to the Earth ellipsoid model is studied, which advances previous studies with a spherical Earth assumption. We perform three analyses. First, an integrated coordination transformation equation, which denotes the geometric relationship between a Moon-based platform and the target on Earth is established based on numerical ephemerides and Earth orientation parameters. Second, the explicit expression for the intersection between the line of sight of the sensor and the Earth oblate spheroid is formulated, and the formulae of uncertainties are given. Lastly, a theoretical visible area on the Earth ellipsoid observed from the sensor is derived based on the geometrical relationship between the observation position and the Earth ellipsoid; two special situations are obtained via explicit expressions and series expansion. Based on this, the optimum radius for the spherical assumption of the Earth is obtained. The simulation and analyses reveal that the proposed mathematical derivation aimed at the Earth spheroid can be used to improve the accuracy of studies focused on the geometrical characteristics of Moon-based Earth observations.
title: Wie alt ist das eigentlich? Ein neues Exponat erklärt Plattenkalk-Forschung im Jura-Museum
Creators: name: Ifrim, Christina
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Das Jura-Museum widmet sich den Fossilien im weltberühmten Solnhofener Plattenkalk. Hier wird ein neues Exponat vorgestellt, dass sich den Solnhofener Plattenkalken über die Fossilien hinaus widmet. Es handelt sich um ein Festgesteins--Transferpräparat aus dem Steinbruch Ettling, das während der Forschungsgrabung angefertigt wurde und die Gesteinsabfolge im Original dokumentiert. Daraus wird ein Exponat, das dem Publikum Einblicke geben soll, wie sedimentäre Abfolgen datiert und interpretiert werden. Der Steinbruch Ettling ist bekannt für seine außerordentlich gut erhaltenen Fische mit Farbmustern. Der einzige Ammonit, der als Altersanzeiger dienen kann, kommt aus einer Bank, die im Transferpräparat enthalten ist. So kann Biostratigraphie anschaulich vermittelt werden. Weitere Forschungsdatenwerden in Zukunft direkt auf das Transferpräparat übertragen. Derzeitige Analysenumfassen mineralogische Zusammensetzung, Nannofazies, Chemostratigraphie und quantitative Auswertungen aus der Forschungsgrabung. Die Ergebnisse, die allein sehr abstrakt wären, sind so anschaulich am Profil vermittelbar. Das Exponat dient somit zur Vermittlung vielfältiger geowissenschaftlicher Ansätze und Fragestellungen weit über den Fossilbestand hinaus und liefert direkte Einblicke in die Forschung.
PROPERTY REDUX. OWNERSHIP OF HUMAN TISSUE AND THE GOVERNANCE OF POST-GENOMIC RESEARCH BIOBANKS
Creators: name: SCHMIETOW, BETTINA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Biobank-based genomic research is considered instrumental to realize Personalised Medicine and considerable benefits for diagnosis and therapy of many common complex diseases. It raises manifold ethical and regulatory challenges which are discussed extensively, the main focus being on adaptations of Informed Consent to the emerging research context. This study highlights challenges to the strongly individualistic focus of classical research ethics in confrontation with biobank development. The debate on adequate protections for individual donor-participants tends towards deflationary accounts of participant rights, in which in particular the dimension of potential property in human tissue and genomic information is undervalued. Criticizing the common bioethical and legal stance that there can and should be no property in the human body and its parts, the close conceptual connections between privacy, property and consent underlying the protection of a more substantive version of participant integrity are emphasized. While ultimately the framework of traditional, in particular individual property rights is ill-suited to safeguard participant and public interests in research, property discourse is fundamental to advance discussion on the direction biobank ethics and governance should take by 1) taking serious the reordering of individual, group and societal interests in biobank research, 2) clarifying strength and limits of claims to ?autonomy? and 3) refocusing to public or common goods biobank research should provide. These foundational insights are applied to an emerging normative model beneath biobank governance in which implications for the future role of consent and participant involvement in large-scale digitalized research projects are outlined.
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
Creators: name: Tay, Jonathan
name: Morris, Robin G
name: Tuladhar, Anil M
name: Husain, Masud
name: De Leeuw, Frank-Erik
name: Markus, Hugh S
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Neuropsychiatry
1506

description: Objective: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods: Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in apathy and depression was used to predict dementia in a subset of 104 participants with longitudinal data from SCANS. All models were controlled for age, education and cognitive function. Results: Baseline apathy scores predicted dementia in SCANS (HR 1.49, 95% CI 1.05 to 2.11, p=0.024) and RUN DMC (HR 1.05, 95% CI 1.01 to 1.09, p=0.007). Increasing apathy was associated with dementia in SCANS (HR 1.53, 95% CI 1.08 to 2.17, p=0.017). In contrast, baseline depression and change in depression did not predict dementia in either dataset. Including apathy in predictive models of dementia improved model fit. Conclusions: Apathy, but not depression, may be a prodromal symptom of dementia in SVD, and may be useful in identifying at-risk individuals.
title: Thermal and gravity field implications of converting a mantle shear-wave velocity tomography of the South China Sea region to temperature and density
Creators: name: Li, Yan
name: Bott, Judith
name: Magdalena, Scheck-Wenderoth
name: Tan, Pingchuan
name: Liu, Shaowen
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The seismic wave velocity configuration of the mantle provides constraints on its thermal and hence density structure, although the proposed methods of wave velocity conversion differ significantly. The V2RhoT_gibbs is a Python tool that allows converting mantle seismic velocities to temperature and density using a Gibbs free energy minimization algorithm applied to a defined mantle chemical composition to guarantee thermodynamic stability of the correspondingpressure (P) and temperature (T) dependent phase and mineral assemblages. Alternative methods, in contrast, start the conversion process with a pre-defined, P and T independent mineralogical composition, while yet other conversion methods involve a set of empirical equations. To better understand the differences between these conversion approaches, we have applied different methods to a shear-wave velocity tomographic model of the mantle below the South China Sea region. The resulting thermal fields are compared regarding the depth of the 1300 °C-isotherm which is a proxy of the lithosphere-asthenosphere boundary. In addition, we present the conversion results in terms of their respective gravity responses. This sensitivity analysis has important implications for better understanding the thermomechanical state of the lithosphere in the region.