cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM2 of Transcriptome analysis of Zymomonas mobilis ZM4 reveals mechanisms of tolerance and detoxification of phenolic aldehyde inhibitors from lignocellulose pretreatment
Creators: name: Yi, Xia
name: Hanqi Gu
name: Qiuqiang Gao
name: Z. Liu
name: Bao, Jie
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Plant Biology

description: Additional file 2. Primers for qRT-PCR of the genes.
ABCA4 structure-function relationships : role in Stargardt disease and related retinal degenerative diseases
Creators: name: Zhong, Ming
Publisher: name: University of British Columbia
Year: 2009

description: ABCA4, also known as ABCR or the rim protein, is a member of the family of ATP binding cassette (ABC) proteins expressed in rod and cone photoreceptors. Mutations in ABCA4 have been linked to Stargardt macular degeneration and related retinal degenerative diseases and implicated in the transport of retinoid compounds across the outer segment disk membrane. This dissertation investigation describes various aspects of the structure and function relationships for ABCA4 and examines the mechanisms by which mutations in ABCA4 lead to various retinal degenerative diseases. A pull-down was employed to identify the retinoid substrate that interacts with ABCA4. When all-trans-retinal was added to ABCA4 in the presence of phosphatidylethanolamine, ~1 mol of N-retinylidene-phosphatidylethanolamine was bound per mol of ABCA4 with an apparent Kd of 5.4 μM. These results provided the first direct biochemical evidence for the identity of the retinoid substrate for ABCA4. To determine the role of that C-terminus of ABCA4 plays in structure and function, a series of deletion and chimera mutants of ABCA4 was expressed, purified by immunoaffinity chromatography, and their biochemical properties analyzed. Removal of the C-terminal 30 amino acids including a conserved VFVNFA motif or substitution of the VFVNFA motif with alanines resulted in the complete loss in N-retinylidene-phosphatidylethanolamine substrate binding, ATP photoaffinity labeling, and retinal stimulated ATPase activity and caused retention of ABCA4 in the endoplasmic reticulum. In contrast mutants lacking the C-terminal 8, 16 or 24 amino acids but retaining the VFVNFA motif were active. These studies indicated that the VFVNFA motif in ABCA4 is required for proper folding of ABCA4 into a functionally active protein. These results provide a molecular rationale for the disease phenotype displayed by individuals with mutations in the C-terminus of ABCA4. Co-IP studies coupled to mass spectrometry were performed to identify novel protein interactors of ABCA4. Rhodopsin and arrestin (including a splice variant of arrestin, p⁴⁴) were identified and confirmed by western blotting. All-trans-retinal was found as a regulator of this interaction. This study for the first time has identified the retinoid substrate for ABCA4, demonstrated a role for the C-terminus and has found protein partners of ABCA4.
Additional file 2: of National youth sedentary behavior and physical activity daily patterns using latent class analysis applied to accelerometry
Creators: name: Evenson, Kelly
name: Wen, Fang
name: Hales, Derek
name: Herring, Amy
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Latent class analysis plotted for (1) weighted average counts/minute/day and weighted percent of (2) sedentary behavior, (3) light activity, (4) moderate to vigorous physical activity and (5) vigorous activity out of total wearing time per day, by age, gender, and school characteristics, among youth 6â  17 years; NHANES 2003â  2006. (PDF 144Â kb)
MOESM4 of Transcriptome analysis of Zymomonas mobilis ZM4 reveals mechanisms of tolerance and detoxification of phenolic aldehyde inhibitors from lignocellulose pretreatment
Creators: name: Yi, Xia
name: Hanqi Gu
name: Qiuqiang Gao
name: Z. Liu
name: Bao, Jie
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Additional file 4. Differentially expressed genes (>2-fold change) under the stress of the phenolic aldehydes in Z. mobilis ZM4.
Additional file 1: of National youth sedentary behavior and physical activity daily patterns using latent class analysis applied to accelerometry
Creators: name: Evenson, Kelly
name: Wen, Fang
name: Hales, Derek
name: Herring, Amy
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Online Table 1: Weighted average physical activity and sedentary behavior in counts/minute or percent by day of the week for each latent class derived from accelerometry, overall and by age, gender, and school characteristics, among youth 6â  17 years; NHANES 2003â  2006. (PDF 56Â kb)
MOESM3 of Transcriptome analysis of Zymomonas mobilis ZM4 reveals mechanisms of tolerance and detoxification of phenolic aldehyde inhibitors from lignocellulose pretreatment
Creators: name: Yi, Xia
name: Hanqi Gu
name: Qiuqiang Gao
name: Z. Liu
name: Bao, Jie
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology

description: Additional file 3. Primers for the construction of the recombinant Z. mobilis ZM4.
Additional file 1: Table S1. of Does provider-initiated HIV testing and counselling lead to higher HIV testing rate and HIV case finding in Rwandan clinics?
Creators: name: Kayigamba, Felix
name: Santen, Daniëla Van
name: Bakker, Mirjam
name: Lammers, Judith
name: Veronicah Mugisha
name: Bagiruwigize, Emmanuel
name: Naeyer, Ludwig De
name: Asiimwe, Anita
name: Loeff, Maarten Schim Van Der
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Characteristics of 65,716 clinic attendees of outpatient departments in eight health facilities by study phase and site, PITC study, Rwanda 2009–2010. Table S2. Multivariable logistic regression to determine the association of study phase with HIV testing rate and HIV case finding in the outpatient department of 2 control health facilities in Rwanda, 2009–2010. Table S3. Characteristics of 77,389 clinic attendees of outpatient and voluntary counseling and testing departments in eight health facilities by study phase and site, PITC study, Rwanda 2009–2010. Table S4. Multivariable logistic regression to determine the association of study phase with HIV testing rate and HIV case finding in the outpatient and voluntary counseling and testing departments of 2 control health facilities in Rwanda, 2009–2010. Figure S1. HIV testing rate and testing cascade in OPD in phase 3 at intervention sites, Rwanda, 2009–10. Figure S2. Reasons for refusing an HIV test in phase 3 at intervention sites, Rwanda, 2009–10. (DOC 311 kb)
Additional file 1: of Structuring evolution: biochemical networks and metabolic diversification in birds
Creators: name: Morrison, Erin
name: Badyaev, Alexander
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: (a) Appendix S1: Confirmed enzymatic reactions in the “avian space” of global carotenoid biosynthesis network in bacteria, plants, and animals. This appendix contains references supporting the presence of specific compounds and the enzymatic reactions that comprise the avian carotenoid biosynthesis global network. (b) Appendix S2: Characteristics of carotenoid metabolic networks for species used in the study. This appendix contains the structural measurements and references for compound identification and the method of identification for each of the species’ metabolic networks. (c) Appendix S3: Module assignments in the avian subset of the global carotenoid metabolic network. This appendix contains the module assignments for each of the compounds in the global avian carotenoid metabolic network. The number of the module corresponds to the partitioned regions in Fig. 2. (PDF 1501 kb)
Antinia Pascoe 1871
Creators: name: Kania, Jarosław
name: Piwnik, Agata
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Antinia

description: Antinia Pascoe, 1871
(type species: Antinia eupleura Pascoe, 1871 by monotypy)
1. eupleura Pascoe, 1871
Malaysia (Penang), Thailand (Khao Chong) 2. pendleburyi Marshall, 1932
Malaysia (Malay Peninsula: Langkawi Is., West Coast) 3. viridis Kojima & Idris, 2003
Malaysia (Cameron Highlands)
description: Published as part of Kania, Jarosław & Piwnik, Agata, 2017, Notes on the genera Antinia Pascoe, 1871 and Dermatodina Faust, 1895 with description of D. boroveci sp. nov. from Thailand (Coleoptera: Curculionidae: Entiminae), pp. 322-330 in Zootaxa 4232 (3) on page 329, DOI: 10.11646/zootaxa.4232.3.2, http://zenodo.org/record/312270
MOESM1 of The clinical utility curve: a proposal to improve the translation of information provided by prediction models to clinicians
Creators: name: Campbell, Duncan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1: Glossary. Glossary of terms.
Dermatodina Faust 1895
Creators: name: Kania, Jarosław
name: Piwnik, Agata
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Dermatodina

description: Dermatodina Faust, 1895 status restituendum
(type species: Dermatodina vitiosa Faust, 1895 by monotypy)
1. boroveci, hoc opus
Thailand (Nan Prov., Ban Huay Kon env.)
2. holynskiorum (Kania & Stojczew, 2001) comb. nov. (from Antinia) Vietnam (Tam Dao)
3. kadeji (Kania & Wiater, 2006) comb. nov. (from Antinia) China (Canton, Ting-wŭ-Asi)
4. szelagowiczi (Kania & Wiater, 2006) comb. nov. (from Antinia) China (Junh Fa Tam)
5. szypulai (Kania, 2001) comb. nov. (from Antinia) Burma (SW Shan State, Taunggyi)
6. variegata (Voss, 1958) comb. nov. (from Antinia) China (Shaowu, Kwangtseh)
7. vitiosa Faust, 1895
Indonesia (Java, Tjisarua and Tjibulan ad Bogor)
description: Published as part of Kania, Jarosław & Piwnik, Agata, 2017, Notes on the genera Antinia Pascoe, 1871 and Dermatodina Faust, 1895 with description of D. boroveci sp. nov. from Thailand (Coleoptera: Curculionidae: Entiminae), pp. 322-330 in Zootaxa 4232 (3) on page 329, DOI: 10.11646/zootaxa.4232.3.2, http://zenodo.org/record/312270
Additional file 1: of Impaired function of endothelial progenitor cells in children with primary systemic vasculitis
Creators: name: Hong, Ying
name: Eleftheriou, Despina
name: Klein, Nigel
name: Brogan, Paul
Publisher: name: Figshare
Year: 2015
Subjects: Medicine
Cell Biology
Neuroscience
Developmental Biology
Hematology

description: Paediatric Vasculitis Activity Score. (PDF 51 kb)
Additional file 2: of Impaired function of endothelial progenitor cells in children with primary systemic vasculitis
Creators: name: Hong, Ying
name: Eleftheriou, Despina
name: Klein, Nigel
name: Brogan, Paul
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Hematology

description: Glossary and scoring for PVAS. (PDF 61 kb)
Cryptococcus gattii isolates induce less protective inflammation than Cryptococcus neoformans in a murine model of infection.
Creators: name: Cheng, Po-Yan
Publisher: name: University of British Columbia
Year: 2009

description: The fungal pathogen Cryptococcus neoformans variety grubii is an opportunistic pathogen of immunocompromised people while the related species, Cryptococcus gattii, appears to infect people regardless of their immune status. The objective of this study was to investigate the differences between C. neoformans and C. gattii infections in a mouse model of cryptococcosis in order to better understand why C. gattii is able to cause disease in immunocompetent hosts. Normally, protective inflammation mediated by neutrophils and an adaptive Th1-type immune response is required for clearance of C. neoformans infections, whereas a Th2-type immune response is inefficient. Furthermore, neutrophils act as important first-responders in innate immunity by initiating the adaptive Th1 immune response during the early stage of infection. We hypothesized that while C. neoformans infections are cleared because they elicit strong protective inflammatory immune responses, C. gattii infections persist because they do not, thus enabling this species to cause disease in immunocompetent hosts. The results support the hypothesis because we found that C. gattii infections induce less protective inflammation than C. neoformans infections with respect to leukocyte recruitment to the sites of infection and cytokine induction. Mice infected with the C. gattii strains tested had less neutrophil migration into their lungs and had a reduced protective cytokine profile, suggesting that C. gattii strains may be able to skew the immune response towards a less efficient response, but not necessarily a Th2 allergic immune response. However, we also observed that the C. gattii strains tested varied in virulence, indicating that their ability to limit protective inflammation is not the only factor involved in their pathogenicity. Overall, these results provide important new insights into the virulence of Cryptococcus species; this information may be useful in understanding the outbreak of C. gattii infections that is occurring in British Columbia.
Additional file 4: Figure S1. of Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence
Creators: name: Zubeyde Bayram-Weston
name: Stone, Timothy
name: Giles, Peter
name: Elliston, Linda
name: Nari Janghra
name: Higgs, Gemma
name: Holmans, Peter
name: Dunnett, Stephen
name: Brooks, Simon
name: Jones, Lesley
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: TANOVA patterns of genes differentially expressed between WT and YAC128 caudate. Plots are sorted by pattern of changed expression and each of the 9 patterns is indicated at the end of the relevant section. The gene ID and the Affymetrix probeset ID are given. Expression is given as Log-2 fold change and the time points are in months. WT = wild-type and HD = YAC128. (PDF 65 kb)
Additional file 2: Table S2. of Opening the “black box” of nodD3, nodD4 and nodD5 genes of Rhizobium tropici strain CIAT 899
Creators: name: Cerro, Pablo Del
name: Rolla-Santos, Amanda
name: Gomes, Douglas
name: Marks, Bettina
name: Espuny, María Del Rosario
name: Rodríguez-Carvajal, Miguel
name: Soria-Díaz, María
name: Nakatani, André
name: Hungria, Mariangela
name: Ollero, Francisco
name: Megías, Manuel
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Nod Factor structure biosynthesized in the presence of apigenin (3.7 μM) by wild type CIAT 899 and derivatives. (DOC 72 kb)
Additional file 2: of Loss of tapasin correlates with diminished CD8+ T-cell immunity and prognosis in colorectal cancer
Creators: name: Sokol, Lena
name: Koelzer, Viktor
name: Rau, Tilman
name: Karamitopoulou, Eva
name: Inti Zlobec
name: Lugli, Alessandro
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Table S1. Patient characteristics (colorectal cancer patient cohort, nÂ =Â 198, max). Clinicopathological features of the 198 patients for which tapasin expression could be analyzed.
Additional file 1: Table S1. of Opening the “black box” of nodD3, nodD4 and nodD5 genes of Rhizobium tropici strain CIAT 899
Creators: name: Cerro, Pablo Del
name: Rolla-Santos, Amanda
name: Gomes, Douglas
name: Marks, Bettina
name: Espuny, María Del Rosario
name: Rodríguez-Carvajal, Miguel
name: Soria-Díaz, María
name: Nakatani, André
name: Hungria, Mariangela
name: Ollero, Francisco
name: Megías, Manuel
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology

description: Nod Factor structure biosynthesized in control condition (B− medium) by wild type CIAT 899 and derivatives. (DOC 45 kb)
Additional file 1: of Treatment of nausea in pregnancy: a cross-sectional multinational web-based study of pregnant women and new mothers
Creators: name: Heitmann, Kristine
name: Holst, Lone
name: Lupattelli, Angela
name: Maltepe, Caroline
name: Nordeng, Hedvig
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: STROBE Statementâ  Checklist of items that should be included in reports of cross-sectional studies. (PDF 96 kb)
Additional file 2: of Anchoring genome sequence to chromosomes of the central bearded dragon (Pogona vitticeps) enables reconstruction of ancestral squamate macrochromosomes and identifies sequence content of the Z chromosome
Creators: name: Deakin, Janine
name: Edwards, Melanie
name: Patel, Hardip
name: OâMeally, Denis
name: Jinmin Lian
name: Stenhouse, Rachael
name: Ryan, Sam
name: Livernois, Alexandra
name: Bhumika Azad
name: Holleley, Clare
name: Qiye Li
name: Georges, Arthur
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Comparison of squamate macrochromosomes for ancestral Squamata, Toxicofera and Iguania reconstructions. (PDF 1578Â kb)
Additional file 4: of New data from basal Australian songbird lineages show that complex structure of MHC class II Î˛ genes has early evolutionary origins within passerines
Creators: name: Shandiya Balasubramaniam
name: Bray, Rebecca
name: Mulder, Raoul
name: Sunnucks, Paul
name: Pavlova, Alexandra
name: Melville, Jane
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Amino acid alignment of 159 nucleotide sites from MHC class II Î˛ exon 2. Amino acid residues distinguishing Meliphagidae, Pardalotidae and Climacteridae are highlighted in grey. (PDF 1154Â kb)
Molecular and genetic analyses of complexes and pathways for retrograde transport to the Golgi
Creators: name: Quenneville, Nicole R.
Publisher: name: University of British Columbia
Year: 2009

description: Proteins and lipids are selectively transported between the Golgi, plasma membrane and endosomes by a network of vesicle-mediated endosomal transport pathways. Trafficking specificity requires the coordination of multiple protein assemblies and signals of compartment identity. Genetic screens, and molecular and biochemical techniques, have revealed many components for endosomal transport, but questions regarding the mechanisms of specificity and the coordination of trafficking pathways remain. The Golgi Associated Retrograde Protein (GARP) complex is required to tether vesicles derived from multiple types of endosomes with the Golgi. In the absence of GARP, retrograde transport from endosomes to the Golgi is abolished, and numerous cargoes are missorted. Mutation of the GARP subunit Vps54 causes motor neuron disease in the mouse, emphasizing the physiological importance of GARP. Tethering requires recognition of multiple membranes, but how GARP recognizes vesicles derived from multiple upstream compartments is not known. In my first body of work, the function of the GARP subunit Vps54 was addressed. The N-terminal portion of Vps54 was found to be important for GARP complex assembly and stability, while the C-terminal portion localized to a compartment with features of an early endosome. In the absence of the C-terminal domain, retrieval of early endosome cargo became dependent on late-endosome retrograde transport. This body of work supports the model that tethers recognize, and possibly distinguish between, upstream compartments. The machinery involved in retrograde transport from endosomes is not fully understood. In my second body of work, genes involved endosomal transport were systematically identified by screening mutant collections with a reporter of early endosome dysfunction. To evaluate the relationships between genes and pathways discovered in this screen, genetic interaction analyses with two phenotypes, growth and endosomal dysfunction, were performed. An analysis of genetic interactions based on trafficking dysfunction revealed interesting genetic relationships between endosomal coat proteins and their regulators. This body of work provides insight into the relationships between endosomal transport pathways and presents a framework to discover relationships between genes and pathways discovered in a genomic screen. Together, this thesis presents a molecular and pathway perspective of endosomal transport that provides insight into pathway specificity and the relationships between pathway components.
MOESM1 of Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice
Creators: name: Petrarca, Claudia
name: Clemente, Emanuela
name: Amato, Valentina
name: Gatta, Alessia
name: Cortese, Sara
name: Lamolinara, Alessia
name: Rossi, Cosmo
name: Zanotta, Stefania
name: Mistrello, Gianni
name: Paganelli, Roberto
name: Gioacchino, Mario
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Additional material and figures.
Additional file 1: Table S1. of Multi-locus sequence data illuminate demographic drivers of Pleistocene speciation in semi-arid southern Australian birds (Cinclosoma spp.)
Creators: name: Dolman, Gaynor
name: Joseph, Leo
Publisher: name: Figshare
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Museum registration and location details of specimens used in this study are listed. (PDF 187Â kb)
Additional file 2: of Treatment of nausea in pregnancy: a cross-sectional multinational web-based study of pregnant women and new mothers
Creators: name: Heitmann, Kristine
name: Holst, Lone
name: Lupattelli, Angela
name: Maltepe, Caroline
name: Nordeng, Hedvig
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Most common medicines used against nausea on 1st and 2nd ATC level according to timing of use in pregnancy among women with nausea in pregnancy. Description of data: A table containing the most common medicines on the 1st and 2nd ATC levels used against nausea according to the timing of use in pregnancy among women with nausea. (PDF 21 kb)
Additional file 4: Table S4. of Opening the “black box” of nodD3, nodD4 and nodD5 genes of Rhizobium tropici strain CIAT 899
Creators: name: Cerro, Pablo Del
name: Rolla-Santos, Amanda
name: Gomes, Douglas
name: Marks, Bettina
name: Espuny, María Del Rosario
name: Rodríguez-Carvajal, Miguel
name: Soria-Díaz, María
name: Nakatani, André
name: Hungria, Mariangela
name: Ollero, Francisco
name: Megías, Manuel
Publisher: name: Figshare
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Sequences of the primers used in the RT-qPCR and sizes of the PCR products obtained. (DOC 37 kb)
Batrachideinae Bolivar 1887
Creators: name: Thomas, M. Jared
name: Skejo, Josip
name: Heads, Sam W.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tetrigidae

description: Subfamily: Batrachideinae Bolívar, 1887
Tribe: Batrachideini Bolívar, 1887
description: Published as part of Thomas, M. Jared, Skejo, Josip & Heads, Sam W., 2019, The last batrachideine of Europe: A new genus and species of pygmy grasshopper (Orthoptera: Tetrigidae) from Eocene Baltic amber, pp. 435-445 in Zootaxa 4686 (3) on page 436, DOI: 10.11646/zootaxa.4686.3.9, http://zenodo.org/record/3491628
Additional file 2: Figure S1. of Multi-locus sequence data illuminate demographic drivers of Pleistocene speciation in semi-arid southern Australian birds (Cinclosoma spp.)
Creators: name: Dolman, Gaynor
name: Joseph, Leo
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Identification of genetic discontinuities using GENELAND: analyses of allelic data from 11 autosomal nuclear loci reveal two distinct genetic clusters either side of the Eyrean Barrier. Posterior densities for k = 1 to 4 clusters and maps of posterior probability to belong to cluster 1 or 2. (PDF 173 kb)
Meganola subseima Hu & Yu & Wang 2019, sp. n.
Creators: name: Hu, Yan-Qing
name: Yu, Yong
name: Wang, Min
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nolidae
Meganola
Meganola subseima

description: Meganola subseima sp. n.
(Figs 1–5)
Type material. Holotype: male, Longcanggou, 1500 m, Yingjing county, Sichuan Prov., 22–30.vii.2015, Leg. Min Wang. Three paratypes: 1 male and 1 female, with the same data as the holotype; 1 male, Nanling, Guangdong Prov., Leg. Min Wang.
Diagnosis. The new species resembles Meganola seima László, Ronkay & Ronkay, 2014 (Figs 6–8). Both of these species can be distinguished by the postmedial line and the medial fascia of forewing and the male genitalia. In the new species, the postmedial line is relatively broad, distinct and straight to inner margin below vein M 2, the medial fascia is blackish brown, while in M. seima the postmedial line is thin, feeble and arched below vein M 2, the medial fascia is brown with black. In the male genitalia, the new species has a clavate and distally arched uncus, a relatively short and widened valva, a relatively short harpe, while M. seima has a tapering and distally sharped uncus, an elongate and relatively slender valva, a long harpe.
Description. Adult (Figs 1 & 4). Wingspan 20–22 mm. Head white; antenna brown, bipectinate in male, filiform in female; labial palpus short, with pale greyish brown scales. Thorax brown. Collar pale greyish brown. Abdomen bronze. Forewing ground color pale greyish brown, costal margin area brown from wing base to the postmedial line, medial fascia blackish brown, terminal area greyish brown; basal line absent; antemedial line blackish brown, arched; medial line poorly discernible; postmedial line blackish brown, arcuate above vein M 2, straight to inner margin below vein M 2; subterminal line grayish brown, wavy; cilia grayish brown. Hindwing more or less greyish brown; cilia greyish brown.
Male genitalia. (Figs 2 & 3). Uncus clavate, arched at apex, longer than harpe; tegumen thin, medium long; valva relatively short, shrink medially; costal margin slightly sclerotized, humped at basal part; sacculus narrow; harpe sclerotized, curved, tapering, widened basally, round at apex; saccus V-shaped. Aedeagus cylindrical, medium long; vesica without cornuti.
Female genitalia. (Fig. 5). Papillae anales moderate; apophysis posterioris slender, longer than apophysis anterioris; apophysis anterioris short; ostium bursae slightly sclerotized, U-shaped; ductus bursae membranous, relatively short, about 2.3 times as long as apophysis posterioris; corpus bursae similarly oval-shaped, membranous, with a narrow and lengthways signum band and a spinule on it.
Distribution. China (Sichuan, Guangdong).
Etymology. The specific name is derived from the species M. seima.
description: Published as part of Hu, Yan-Qing, Yu, Yong & Wang, Min, 2019, Taxonomic study of the genus Meganola (Lepidoptera, Nolidae, Nolinae), with three new species and a new record from China, pp. 289-294 in Zootaxa 4586 (2) on page 290, DOI: 10.11646/zootaxa.4586.2.5, http://zenodo.org/record/2644492
Additional file 1: Figure S1. of The evolution of heat shock protein sequences, cis-regulatory elements, and expression profiles in the eusocial Hymenoptera
Creators: name: Nguyen, Andrew
name: Gotelli, Nicholas
name: Cahan, Sara
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Maximum likelihood phylogeny of Hsp60 (mitochondrial form) for 17 species of insects (rooted on A. pisum) using a JTT amino acid substitution model and 1000 bootstraps replicates. (DOCX 233 kb)
Additional file 1: Figure S1. of Effects of thromboprophylaxis on mesenchymal stromal cells during osteogenic differentiation: an in-vitro study comparing enoxaparin with rivaroxaban
Creators: name: Pilge, Hakan
name: FrĂśbel, Julia
name: Mrotzek, Silvia
name: Fischer, Johannes
name: Prodinger, Peter
name: Zilkens, Christoph
name: Bittersohl, Bernd
name: RĂźdiger Krauspe
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: GAPDH Ct values show that there are no significant changes in the expression level of this gene over time and during drug treatment revealing that it can be used as housekeeping gene in this experimental set-up. (DOC 45Â kb)
MOESM7 of Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome
Creators: name: Billing-Ross, Paul
name: Germain, Arnaud
name: Kaixiong Ye
name: Keinan, Alon
name: Zhenglong Gu
name: Hanson, Maureen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 7: Table S5. Association analysis of mtDNA SNPs in males.
Additional file 2: Figure S2. of The evolution of heat shock protein sequences, cis-regulatory elements, and expression profiles in the eusocial Hymenoptera
Creators: name: Nguyen, Andrew
name: Gotelli, Nicholas
name: Cahan, Sara
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Maximum likelihood phylogeny of hsc70-3 (BIP) for 17 species of insects (rooted on A. pisum) using a JTT amino acid substitution model and 1000 bootstrap replicates. (DOCX 230 kb)
Meganola wulongensis Hu & Yu & Wang 2019, sp. n.
Creators: name: Hu, Yan-Qing
name: Yu, Yong
name: Wang, Min
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nolidae
Meganola
Meganola wulongensis

description: Meganola wulongensis sp. n.
(Figs 15–17)
Type material. Holotype: male, Wulong, Chongqing, 9–10.vii.2018, Leg. Yong Yu & Yanqing Hu. Two paratypes: 1 male, Fangjia, Nanbu county, Sichuan Prov., 7–8.vii.2018, Leg. Yong Yu & Yanqing Hu; 1 male, Rongjiang county, Guizhou Prov., 16–18.vii.2018, Leg. Yong Yu & Yanqing Hu.
Diagnosis. In the male genitalia, the new species resembles Meganola zegzugminta László, Ronkay & Ronkay, 2014 (Figs 19 & 20), but these two species of wing pattern are completely different (Figs 15 & 18). In the new species, the antemedial and medial lines are poorly visible and fused with medial fascia, the postmedial line is zigzag, the subterminal line is striped, while in M. zegzugminta the antemedial and medial lines are fine and distinct without medial fascia, the postmedial line is wavy, the subterminal is feeble and represented with a row of short lines. In the male genitalia, the new species has a broad uncus, a narrow tegumen, a curved harpe with dentations, a short saccus and aedeagus, while M. zegzugminta has a slender uncus, a relatively broad tegumen, a relatively straight harpe without the obvious dentation, a long saccus and aedeagus.
Description. Adult (Fig. 15). Wingspan 12–15 mm. Head greyish brown; antenna brown, bipectinate in male; labial palpus brown. Thorax darker brown. Collar greyish brown. Abdomen brown. Forewing ground color pale greyish brown, costal margin area darker brown from wing base to the subterminal line, the medial fascia blackish brown; basal line darker brown; antemedial and medial lines poorly discernible; postmedial line blackish brown, excurved to vein R 4, incurved and arched to vein M 3, then incurved to inner margin; subterminal line darker brown, arched. Hindwing more or less greyish brown.
Male genitalia. (Figs 16 & 17). Uncus broad, tapering, sharped apically; tegumen thin, broad basally, medium long; valva slender, narrow medially; costal margin sclerotized; sacculus small; harpe upcurved distally, pointed apically, with dentations at costal margin; saccus relatively shorter than uncus, V-shaped. Aedeagus cylindrical; vesica without cornuti.
Female. Unknown.
Distribution. China (Chongqing, Sichuan, Guizhou).
Etymology. The specific name is derived from the type-locality.
description: Published as part of Hu, Yan-Qing, Yu, Yong & Wang, Min, 2019, Taxonomic study of the genus Meganola (Lepidoptera, Nolidae, Nolinae), with three new species and a new record from China, pp. 289-294 in Zootaxa 4586 (2) on pages 292-293, DOI: 10.11646/zootaxa.4586.2.5, http://zenodo.org/record/2644492
Additional file 1: of Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
Creators: name: Matula, Kasia
name: Collie-Duguid, Elaina
name: Murray, Graeme
name: Khyati Parikh
name: Grabsch, Heike
name: Tan, Patrick
name: Lalwani, Salina
name: Garau, Roberta
name: Yuhan Ong
name: Bain, Gillian
name: Asa-Dahle Smith
name: Urquhart, Gordon
name: Bielawski, Jacek
name: Finnegan, Michael
name: Petty, Russell
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Additional information 1. Additional information on generation of drug resistant cell lines. Additional information 2. Details of sample preparation and gene expression profiling. Additional information 3. Gene expression Data. Additional information 4. PCR primer sequences. Additional information 5. Additional details of analysis and quantification of sphingosine-1-phosphatefrom cell lines using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Additional information 6. Additional details of chemotherapy treatment of patients. Additional information 7. Pathways identified in Gene enrichment analysis (DAVID v6.7) of resistant cell lines. (PDF 725 kb)
MOESM5 of Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome
Creators: name: Billing-Ross, Paul
name: Germain, Arnaud
name: Kaixiong Ye
name: Keinan, Alon
name: Zhenglong Gu
name: Hanson, Maureen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 5: Table S3. Association analysis of mtDNA SNPs within ME/CFS status.
Aboriginal women's experiences seeking help in an urban emergency department
Creators: name: Su, Michelle
Publisher: name: University of British Columbia
Year: 2009

description: Many Aboriginal women living in inner city areas are affected by structural inequities, racialization and other marginalizing practices, which in turn affect their health and access to health services. It is against this backdrop that some Aboriginal women seek help at emergency departments for health issues that, ostensibly, could be addressed in community-based primary care settings. The purpose of this study was to explore the social and political contexts of access to primary care from the perspective of Aboriginal women who attended an emergency department for health issues triaged as stable and non-urgent. It is anticipated that the findings of this study will be used to inform strategies for improving primary care services, in particular for Aboriginal women living in urban areas. This study involved a secondary analysis of interviews gathered during a larger ethnographic study. It was decided a subset consisting of all 13 Aboriginal women’s interviews from the primary study would be analyzed. In keeping with a critical cultural perspective, cultural safety was used as an analytical lens to examine the social contexts and influences that led Aboriginal women in this study to seek care at an emergency department for health concerns that were triaged as stable and non-urgent. The tensions Aboriginal women experienced in this study while seeking care were also explored. Using the methodology of interpretive description as a guide for analysis, four central themes were discussed. The four themes consisted of: 1) needing a safe place to live, 2) negotiating pain management, 3) seeking help against a backdrop of violence and trauma, and 4) the perception of discrimination and the awareness of how one will be read during health care encounters. These findings have implications for understanding the influences that shape health care experiences, the role of the emergency department in relation to primary health care, minimizing the potential for emotional trauma and structural violence in the emergency department, and fostering greater equity in health services.
Meganola mediofascia
Creators: name: Hu, Yan-Qing
name: Yu, Yong
name: Wang, Min
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nolidae
Meganola
Meganola mediofascia

description: Meganola mediofascia (Inoue, 1958)
(Figs 21–23)
Roeselia mediofascia Inoue, 1958: 235. Type-locality: Japan.
Meganola mediofascia: Kononenko & Han, 2007: 69.
Material examined. 1 male, Yangjiawan, 800 m, Jialingjiang, Qinling Mts., Shaanxi Prov., 10.viii.2012, Leg. Min Wang.
Distribution. China (Shaanxi), Korea, Japan.
Remarks. This species is new to China.
description: Published as part of Hu, Yan-Qing, Yu, Yong & Wang, Min, 2019, Taxonomic study of the genus Meganola (Lepidoptera, Nolidae, Nolinae), with three new species and a new record from China, pp. 289-294 in Zootaxa 4586 (2) on page 293, DOI: 10.11646/zootaxa.4586.2.5, http://zenodo.org/record/2644492
Additional file 1: Figure S1. of Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
Creators: name: Sohn, Peter
name: Tracy, Tara
name: Hye-In Son
name: Yungui Zhou
name: Leite, Renata
name: Miller, Bruce
name: Seeley, William
name: Grinberg, Lea
name: Gan, Li
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Ac-K274 tau inclusions in human tauopathy brains. (A-C) Representative images of ac-K274 tau immunostaining in the inferior temporal cortex of human tauopathy brains. Scale bars, 50 μm. (A) Cytoplasmic tau inclusions (arrows) in the brain of an FTDP-17 patient. (B) Corticobasal bodies (arrows) in a patient with the A152T tau mutation. (C) Neurofibrillary tangles (arrows) in an AD brain. Scale bars, 50 μm. Figure S2. K274/281Q tau has reduced affinity for MTs. (A) Representative images of co-localization of GFP-tubulin and mApple-tauWT in a HeLa cell. (B–D) MT-binding assay in HeLa cells co-transfected with GFP-tau mutant and mApple-tauWT. (B) Representative images of HeLa cells co-transfected with GFP-tauK274/281Q or -tauK274/281R and mApple-tauWT. GFP-tauK274/281Q is distributed diffusely in the cytoplasm. mApple-tauWT appears to bind to MTs. (C,D) Quantification of MT-unbound tau and levels of tau in HeLa cells co-transfected with GFP-mutant tau and mApple-tauWT. 4KQ(N) denotes GFP-tauK163/174/180/190Q. n = 60–90 cells/group from two to three independent experiments. ***p