cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer
Creators: name: Sivapalan, Lavanya
name: Thorn, Graeme J.
name: Gadaleta, Emanuela
name: Kocher, Hemant M.
name: Ross-Adams, Helen
name: Chelala, Claude
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 2: Supplementary Table 1. Summary of the clinical characteristics of the study cohort. Supplementary Table 2. Summary of mean sequencing depths and the number of somatic variants called in tumour and PDAC plasma samples analysed. Supplementary Table 3. Summary of ctDNA variant allele fractions (VAFs) for potentially actionable DNA damage repair (DDR) mutations detected per patient and plasma timepoint for the exploratory cohort
Development of a Thoracic Personal Sampler System for Co-Sampling of Sulfuric Acid Mist and Sulfur Dioxide Gas
Creators: name: Chih-Hsiang Chien
name: Theodore, Alexandros
name: Chufan Zhou
name: Wu, Chang-Yu
name: Hsu, Yu-Mei
name: Birky, Brian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: A novel personal sampler was designed to measure inorganic acid mists and gases for determining human exposure levels to these acids in workplaces. This sampler consists of (1) a parallel impactor for classifying aerosol by size following the ISO/CEN/ACGIH defined human thoracic fraction, (2) a cellulose filter to collect the residual acid mist but allowing penetration of sulfur dioxide gas, and (3) an accordion-shaped porous membrane denuder (aPMD) for adsorbing the penetrating sulfur dioxide gas. Acid-resistant PTFE was chosen as the housing material to minimize sampling interference. To test the performance of the parallel impactor, monodisperse aerosol was created by a vibrating orifice aerosol generator. The results showed that the penetration curve of the impactor run at 2 LPM flow rate agreed well with the defined thoracic fraction. Almost all sampling biases were within 10% for particle size distributions with MMAD between 1 – 25 µm and GSD between 1.75 – 4, which meets the criteria of the EN 13205 standard. To evaluate the performance of the aPMDs, sulfur dioxide gas was sourced directly from a cylinder. The aPMDs maintained a gas collection efficiency greater than 95% for 4 hours when sampling 8.6 ppm of sulfur dioxide gas. While the aPMD had similar performance to the commonly adopted annular or honeycomb denuders made of glass, this shatterproof aPMD is only half of the volume and 1/25th the weight of the honeycomb denuder. Testing of the entire sampler with a mixture of sulfuric acid mist and sulfur dioxide gas showed the system could sample both with negligible interference. All the test results illustrate that the new sampler, which is flat, lightweight and portable, is suitable for personal use and is capable of a more accurate assessment of human exposure to inorganic acid mist and SO2 gas.
Eco-Friendly Rapid Synthesis of 3-Substituted-2-Thioxo-2,3-Dihydroquinazolin-4(1H)-Ones in Choline Chloride Based Deep Eutectic Solvent
Creators: name: Molnar, Maja
name: Klenkar, Jelena
name: Tarnai, Tena
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: A series of 3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 6-iodo-3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones were synthesized in choline chloride/urea deep eutectic solvent. Substituted 2-mercapto-4(3H)-quinazolinones were synthesized from anthranilic acid or 5-iodoanthranilic acid and appropriate isothiocyanates in good to excellent yields. Isolation of final product was easy and required no further purification. Synthesis of these compounds was rapid, selective and catalyst free, while preparation of deep eutectic solvent was easy, components are readily available, cheap and environmentally friendly.
Z- and E-selective Horner-Wadsworth-Emmons (HWE) Reactions
Creators: name: Molnár, Katalin
name: Takács, László
name: Kádár, Mihály
name: Faigl, Ferenc
name: Kardos, Zsuzsanna
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In the present work, we determined and evaluated the stereochemical outcome of the Horner-Wadsworth-Emmons (HWE) reaction of 2-oxoalkylphosphonates with different ester functions (bis(2,2,2-trifluoroethyl), 2,2,2-trifluoroethyl methyl, dimethyl) and side-chains (aliphatic, aromatic) with three different aldehydes (benzaldehyde, THP- and PPB-protected Corey aldehydes) under two reaction conditions. The “trans” protocol is generally used in the E-selective HWE reactions, while “cis” protocol promotes the Z-selectivity.
Intercultural and Native Speakers’ Casual Conversations: A Comparative Study of Involvement and Humour
Creators: name: Lopez, Elise
name: Yang, Jie
name: Vu, Thao
name: Yusnita Febrianti
Publisher: name: Monash University
Year: 2016
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: Abstract for presentation at ALAA2016/ALS2016 joint day.
Platelet index levels and cardiovascular mortality in incident peritoneal dialysis patients: a cohort study
Creators: name: Peng, Fenfen
name: Li, Zhijian
name: Yi, Chunyan
name: Guo, Qunying
name: Yang, Rui
name: Long, Haibo
name: Huang, Fengxian
name: Yu, Xueqing
name: Yang, Xiao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Prior studies have shown that the levels of some platelet (PLT) indices were associated with mortality in patients undergoing hemodialysis. We aimed to investigate whether the changes in PLT indices associated with mortality in patients on peritoneal dialysis (PD). A single-center, retrospective observational cohort study was conducted in incident PD patients from 1 January 2006 to 31 December 2012, and followed up until 31 December 2014. Cox proportional hazard models were used to examine the relationships between the levels of PLT indices including PLT, plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), and mortality. Of 1324 patients, 276 (20.8%) died during follow-up (median, 37; IQR, 3–107.4 months), among which 134 were due to cardiovascular diseases (CVD). The highest tertile of PLT levels at baseline was associated with increased risk for cardiovascular mortality after adjustment for demographic, clinical characteristics, and laboratory variables (hazard ratio [HR]:1.93; 95% confidence interval [CI]: 1.16–3.20). The similar treads were also observed in the middle and the highest tertile of the PCT level (HR: 1.68, 95%CI: 1.00–2.81 and HR: 1.89, 95%CI: 1.14–3.14, respectively). In addition, the highest tertile of PCT was associated with increased all-cause mortality (HR: 1.41, 95%CI: 1.01–1.96). However, none of the associations in MPV, PDW, and PLCR analyses reached statistical significance (HR: 0.71, 95%CI: 0.43–1.16; HR: 0.72, 95%CI: 0.45–1.18 and HR: 0.74, 95%CI: 0.46–1.19, respectively). These results suggest that higher PLT and PCT may be associated with higher risk for cardiovascular mortality in incident PD patients. Additional studies are needed to investigate whether correction of these two PLT indices reduces the risk.
Efficient copper-catalyzed sonogashira coupling reactions and simulation studies
Creators: name: Ali, Imran
name: Dnyaneshwar Nighot
name: Lone, Mohammad Nadeem
name: Jain, Arvind
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: A practical copper-catalyzed I-substitutions of alkyl-2-iodobenzoates with alkynes have been developed using Cu powder as a catalyst under solvent, cocatalyst, and base-free conditions. This reaction system is new, facile, efficient, and economical that gives Sonogashira coupling products in excellent yields (up to 97%). The coupled products (A–J) were characterized by CHNS, 1H NMR, and 13C NMR and are found soluble in ethyl acetate and dichloromethane. In addition, simulation studies of A–J were performed with aspulvinone dimethylallyltransferase enzyme and observe good binding affinity. The reported compounds may act as anti-cizmatics, anti-fobic in future and also have the inhibition of aspulvinone dimethylallyltransferase properties to control Alzheimer’s, Schizophrenia, etc. diseases.
Eco-friendly rapid synthesis of 3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent
Creators: name: Molnar, Maja
name: Klenkar, Jelena
name: Tarnai, Tena
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: A series of 3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 6-iodo-3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones were synthesized in choline chloride/urea deep eutectic solvent. Substituted 2-mercapto-4(3H)-quinazolinones were synthesized from anthranilic acid or 5-iodoanthranilic acid and appropriate isothiocyanates in good to excellent yields. Isolation of final product was easy and required no further purification. Synthesis of these compounds was rapid, selective, and catalyst free, while preparation of deep eutectic solvent was easy, components are readily available, cheap, and environmentally friendly.
Rainfall, but not temperature, negatively affects the growth of Blue Tit Cyanistes caeruleus nestlings
Creators: name: Morganti, Michelangelo
name: Rubolini, Diego
name: Caprioli, Manuela
name: Saino, Nicola
name: Ambrosini, Roberto
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Capsule: Growth trajectories of Blue Tit Cyanistes caeruleus nestlings differed between sexes and were negatively affected by rain but not by temperature during the linear growth phase (LGP). Aims: To model the growth trajectories of Blue Tit nestlings and to identify the main ecological factors affecting them. Methods: Sixty-five nestling Blue Tits from a population in northern Italy were weighed at regular intervals and sexed using molecular genetic techniques. The LGP period was identified and analysed to test for the influence of age, sex, hatching date, brood size, temperature and rainfall on individual daily growth rates during the LGP. Results: Growth curves showed no pre-fledging mass loss. Body mass differed between the sexes, with males being 5% heavier than females at the pre-fledging stage. Daily growth rates during the LGP were higher for males and on non-rainy days, while they were not affected by other factors. Conclusion: The higher daily growth rate observed in males during the LGP may determine the extent of sexual size dimorphism at the pre-fledging stage. Susceptibility of growth trajectories to environmental conditions was limited to rainfall and was similar in the two sexes. This contrasts with findings from previous studies, which found sex-biased environmental sensitivity of Blue Tit nestlings.
Developing students’ English language capability and advancing academic learning through translanguaging practices: a case study in higher education
Creators: name: O'Neill, Fiona
name: Li, Xuan
name: Heugh, Kathleen
Publisher: name: Monash University
Year: 2016
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: Abstract for presentation at ALAA2016 conference.
Continuous Adsorption of a Cationic Dye on Surface Modified Rice Husk: Statistical Optimization and Dynamic Models
Creators: name: Dison S. P. Franco
name: Tanabe, Eduardo H.
name: Dotto, Guilherme L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The continuous adsorption of a cationic dye (Methylene Blue, MB) on surface-modified rice husk was investigated. First, rice husk was submitted to ultrasound-assisted, supercritical CO2 and NaOH treatments. The adsorbents were characterized. Then, the continuous adsorption was optimized by response surface methodology (RSM), using raw rice husk as the adsorbent. Finally, under the optimal conditions, breakthrough curves were obtained using all adsorbents and the models were used to interpret these curves. The optimal bed performance was reached at a flow rate of 5 mL min−1 and an initial MB concentration of 10 mg L−1. Under these conditions, the breakthrough time was 109 min, the length of the mass transfer zone was 20.1 cm, and the maximum capacity of the column was 1.55 mg g−1. All surface modifications were able to improve the rice husk characteristics in relation to the MB adsorption. Consequently, the bed performance was significantly improved when the surface-modified adsorbents were used. The breakthrough times were 109, 240, 155, and 385 min, respectively, when raw rice husk, UA–rice husk, SCO2–rice husk, and NaOH–rice husk were used. The length of the mass transfer zone was 20.1, 7.9, 15.9, and 9.3 cm for raw rice husk, UA–rice husk, SCO2–rice husk, and NaOH–rice husk, respectively. The dynamic models were able to fit the adsorption data and provided physically consistent parameters.
Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system
Creators: name: Haseeb, Muhammad Tahir
name: Ajaz Hussain, Muhammad
name: Bashir, Sajid
name: Ashraf, Muhammad Umer
name: Ahmad, Naveed
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biophysics
Biochemistry
Space Science
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mental Health

description: Context: Advancement in technology has transformed the conventional dosage forms to intelligent drug delivery systems. Such systems are helpful for targeted and efficient drug delivery with minimum side effects. Drug release from these systems is governed and controlled by external stimuli (pH, enzymes, ions, glucose, etc.). Polymeric biomaterial having stimuli-responsive properties has opened a new area in drug delivery approach. Objective: Potential of a polysaccharide (rhamnogalacturonan)-based hydrogel from Linseeds (Linum usitatissimum L.) was investigated as an intelligent drug delivery material. Materials and methods: Different concentrations of Linseed hydrogel (LSH) were used to prepare caffeine and diacerein tablets and further investigated for pH and salt solution-responsive swelling, pH-dependent drug release, and release kinetics. Morphology of tablets was observed using SEM. Results: LSH tablets exhibited dynamic swelling–deswelling behavior with tendency to swell at pH 7.4 and in deionized water while deswell at pH 1.2, in normal saline and ethanol. Consequently, pH controlled release of the drugs was observed from tablets with lower release (<10%) at pH 1.2 and higher release at pH 6.8 and 7.4. SEM showed elongated channels in swollen then freeze-dried tablets. Discussion: The drug release was greatly influenced by the amount of LSH in the tablets. Drug release from LSH tablets was governed by the non-Fickian diffusion. Conclusions: These finding indicates that LSH holds potential to be developed as sustained release material for tablet.
Additional file 1 of IgA nephropathy relapse following COVID-19 vaccination treated with corticosteroid therapy: case report
Creators: name: Watanabe, Shota
name: Zheng, Shuling
name: Rashidi, Arash
Publisher: name: figshare
Year: 2022
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1.
Networkers, fund hunters, intermediaries, or policy players? The activities of regions in Brussels
Creators: name: Tatham, Michaël
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Regions started opening offices in Brussels in the mid-1980s. Today, well over half of Europe’s regions are present there. What do they do once they are in Brussels? Are they mainly networking, chasing funding, acting as intermediaries, monitoring legislation, or trying to influence the EU’s decision-making process? No study has analysed this question apart from the pioneering work by Marks et al. in 2002. This article breaks new ground by analysing both group-level and contextual factors in a series of multilevel models. Based on a survey of regional offices in Brussels, results indicate that contextual factors, such as levels of self-government back home, matter. However, group-level characteristics, such as an office’s longevity in Brussels, seem to affect a wider range of activities. Overall, older offices are more interested in the EU policy-making process and less interested in chasing funds or networking. Conversely, offices representing regions with weaker self-governing capacities rather conceive of their role as that of an intermediary, acting as an interface between the region and the EU institutions.
Supplementary materials from Biomechanics of aerial righting in wingless nymphal stick insects
Creators: name: Zeng, Yu
name: Lam, Kenrick
name: Chen, Yuexiang
name: Gong, Mengsha
name: Xu, Zheyuan
name: Dudley, Robert
Publisher: name: The Royal Society
Year: 2016

description: Numerous wingless arthropods as well as diverse vertebrates are capable of mid-air righting. We studied the biomechanics of the aerial righting reflex in first-instar nymphs of the stick insect Extatosoma tiaratum. After being released upside-down, insects reoriented dorsoventrally and stabilized body posture via active modulation of limb positions and associated aerodynamic torques. We identified specific reflexes for bilaterally asymmetric leg displacements which elicit body rotation and subsequently stabilize mid-air posture. Coordinated appendicular movements thus improve torsional manoeuvrability in the absence of wings, as may have characterized the initial origins of controlled aerial behaviour in arthropods. Design of small aerial or multimodal robotic vehicles may similarly benefit from use of such strategies for flight control.
Foraging on human-derived foods by urban bird species
Creators: name: Støstad, Hanna N.
name: Aldwinckle, Phil
name: Allan, Andrew
name: Arnold, Kathryn E
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Capsule: Providing peanuts on bird feeders was shown to attract more individuals and more species than providing cheese or bread. Aims: To investigate how the provision of different human-derived foods affected visit rates of urban birds at bird feeders. Methods: A fully replicated study design was set up in parkland, offering a binary choice from three food types (peanuts, bread and cheese) on bird tables. Birds were observed by using a scan-sample method. Results: Peanuts attracted more visits, and a greater diversity of bird species, than cheese or bread. This preference was strongest for Blue Tits Cyanistes caeruleus and Great Tits Parus major, whereas European Robins Erithacus rubecula visited all food types equally, and Blackbirds Turdus merula preferred cheese. Bread was the most consumed food type when measured by mass, but this could be linked to varying bite sizes. Conclusion: Our results indicate that birds preferred to visit feeding stations with the most protein- and energy-rich foods, but that some birds still chose the carbohydrate-rich bread. The findings indicate that peanuts, rather than household scraps like bread and cheese, attract the highest number of species and individuals to bird tables. The findings will be of interest to the public and to organizations providing information on bird feeding for recreational purposes.
Phenolic compounds in black currant leaves – an interaction between the plant and foliar diseases?
Creators: name: Vagiri, Michael
name: Johansson, Eva
name: Rumpunen, Kimmo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology
subject: 60506 Virology

description: Interactions between phenolic compounds in black currant leaves and foliar diseases may be important in breeding for resistant genotypes with a nutritional high profile for human applications. For increased understanding of such interactions, we evaluated the presence of major fungal diseases by visual inspection, and content of phenolic compounds by HPLC in leaves of five segregating black currant breeding populations. Eight individual flavonols (e.g. quercetin-3-O-glucoside, quercetin-3-O-rutinoside and kaempferol-malonylgucoside), three flavan-3-ols (epigallocatechin, catechin and epicatechin) and two chlorogenic acids (neochlorogenic acid and chlorogenic acid) were significantly correlated to the leaf diseases. Rib-0701 was the population possessing the highest content for several of the compounds, while genotype differences existed for content of various phenolic compounds and resistance to the diseases. The high variability of content of phenolic compounds opens up for opportunities to breed resistant genotypes with improved health properties of the leaves for functional food products.
data (RAW & EDITED)
Creators: name: Donya Azizi Babani
name: Wenze Dai
Publisher: name: OSF Registries
Year: 2019
Subjects: Arab
Cisgender
Competence
Discrimination
Employablity
Ethnicity
Fake CV
Intersectionality
LGBT
Stereotype
Swede
Transgender
Warmth

description: Our data files. please note the information in Wiki section.
Cu(I)-promoted one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from anti-3-aryl-2,3-dibromopropanoic acids and nitrobenzaldehydes
Creators: name: Liu, Xia
name: Su, Changhui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Information Systems not elsewhere classified
subject: Hematology

description: A series of 1,4-disubstituted 1,2,3-triazoles were synthesized through a one-pot process from easily available anti-3-aryl-2,3-dibromopropanoic acids and nitrobenzaldehydes in hexamethylphosphoric triamide. Inexpensive copper(I) iodide was the catalyst.
Cu(I)-promoted One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Anti-3-Aryl-2,3-dibromopropanoic Acids and Nitrobenzaldehydes
Creators: name: Liu, Xia
name: Su, Changhui
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Information Systems not elsewhere classified
subject: Hematology

description: A series of 1,4-disubstituted 1,2,3-triazoles were synthesized through a one-pot process from easily available anti-3-aryl-2,3-dibromopropanoic acids and nitrobenzaldehydes in hexamethylphosphoric triamide (HMPT). Inexpensive copper(I) iodide was the catalyst.
Density functional theory for modelling large molecular adsorbate–surface interactions: a mini-review and worked example
Creators: name: Janet, Jon Paul
name: Zhao, Qing
name: Ioannidis, Efthymios I.
name: Kulik, Heather J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: First-principles simulation has played an ever-increasing role in the discovery and interpretation of the chemical properties of surface–adsorbate interactions. Nevertheless, key challenges remain for the computational chemist wishing to study surface chemistry: modelling the full extent of experimental conditions, managing computational cost, minimising human effort in simulation set-up and maximising accuracy. This article introduces new tools for streamlining surface chemistry simulation set-up and reviews some of the challenges in first-principles, density functional theory (DFT) simulation of surface phenomena. Furthermore, we provide a worked example of Co tetraphenylporphyrin on Au(1 1 1) in which we analyse electronic and energetic properties with semi-local DFT and compare to predictions made from hybrid functional and the so-called DFT+U correction. Through both review and the worked example, we aim to provide a pedagogical introduction to the challenges and the insight that first-principles simulation can provide in surface chemistry.
Additional file 1 of Protein purification strategies must consider downstream applications and individual biological characteristics
Creators: name: Remans, Kim
name: Lebendiker, Mario
name: Abreu, Celeste
name: Maffei, Mariano
name: Sellathurai, Shaila
name: May, Marina M.
name: Vaněk, Ondřej
name: de Marco, Ario
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplementary Materials
Complementary Data File and Results from In situ observation of fracture processes in high-strength concretes and limestone using high-speed X-ray phase-contrast imaging
Creators: name: Parab, Niranjan D.
name: Guo, Zherui
name: Hudspeth, Matthew
name: Claus, Benjamin
name: Lim, Boon Him
name: Sun, Tao
name: Xiao, Xianghui
name: Fezzaa, Kamel
name: Chen, Weinong W.
Publisher: name: The Royal Society
Year: 2016

description: Mechanical properties and fracture mechanisms of geomaterials and construction materials such as concrete are reported to be dependent on the loading rates. However, the in situ cracking inside such specimens cannot be visualized using traditional optical imaging methods since the materials are opaque. In this study, the in situ sub-surface failure/damage mechanisms in cor-tuf (a reactive powder concrete), a high-strength concrete (HSC) and Indiana limestone under dynamic loading were investigated using high-speed synchrotron X-ray phase-contrast imaging. Dynamic compressive loading was applied using a modified Kolsky bar and fracture images were recorded using a synchronized high-speed synchrotron X-ray imaging set-up. Three-dimensional synchrotron X-ray tomography was also performed to record the microstructure of the specimens before dynamic loading. In cor-tuf and HSC specimens, two different modes of cracking were observed: straight cracking or angular cracking with respect to the direction of loading. In limestone, cracks followed the grain boundaries and voids ultimately fracturing the specimen. Cracks in HSC were more tortuous than the cracks in cor-tuf specimens. The effects of the microstructure on the observed cracking behaviour are discussed.
Intervention Effects on Stage of Change Membership and Transitions among Adolescent Energy Balance Behaviors
Creators: name: Brick, Leslie A.
name: Redding, Colleen A.
name: Paiva, Andrea L.
name: Harlow, Lisa L.
name: Velicer, Wayne F.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The transition from childhood to adolescence is a crucial period for the development of healthy behaviors to be sustained later in life. With obesity a leading public health problem, the promotion of healthy behaviors has the potential to make a huge impact. The current study evaluated Stage of Change progression in a large (N = 4158) computer-delivered, Transtheoretical Model-tailored intervention focusing on physical activity and fruit and vegetable consumption (FV). Markov models were used to explore stage transitions and patterns of discrete change from sixth to ninth grade. Nested model comparisons examined the consistency of these patterns across time and intervention condition. Major findings supported models in which participants were free to transition forward and backward to any of the stages, but higher probabilities were observed for remaining in the same stage or for transitioning one or two stages forward. Participants in the intervention group had higher probabilities of transitioning toward Maintenance, with more change occurring relative to the comparison group during transitions from grades six to eight but not for grades eight to nine.
Supplementary Materials from Experience-dependent homeostasis of ‘noise’ at inhibitory synapses preserves information coding in adult visual cortex
Creators: name: Gao, Ming
name: Whitt, Jessica L.
name: Huang, Shiyong
name: Lee, Angela
name: Mihalas, Stefan
name: Kirkwood, Alfredo
name: Lee, Hey-Kyoung
Publisher: name: The Royal Society
Year: 2016

description: Figures S1-S8; Table S1; Supplementary Methods
Additional file 1 of Attractiveness of medical disciplines amongst Swiss first-year medical students allocated to different medical education tracks: cross-sectional study
Creators: name: Markun, Stefan
name: Tandjung, Ryan
name: Rosemann, Thomas
name: Scherz, Nathalie
name: Senn, Oliver
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary file 1. Sankey plot showing proportions and (re-)assignment flow of applicants to specific medical education tracks in 2019. The first vertical bar from the left represents the total of applicants, the stack of vertical bars represents the proportion of applicants to specific medical education tracks, the third stack of bars the proportion of applicants passing the aptitude test (“Eignungstest”) and the forth stack of bars the actual allocation to specific medical education tracks. At each node the total number applicants is given.
Performance of an anaerobic membrane bioreactor in which granular sludge and dynamic filtration are integrated
Creators: name: Yang, Jixiang
name: Ji, Xin
name: Lu, Lunhui
name: Ma, Hua
name: Chen, Youpeng
name: Guo, Jinsong
name: Fang, Fang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: To alleviate the fouling of a filter, simple substrates, dynamic filtration, and granular sludge were applied in an anaerobic membrane bioreactor (AnMBR). The results showed that under a transmembrane pressure < 20 kPa, the filter flux ranged between 15 and 20 l (m−2 h)−1 for a period of 30 days. The flux was higher than the typical flux of AnMBRs with conventional membranes and most current dynamic filters. In addition, the low cost of the filter avoided the need for a higher flux. Moreover, a stable granular sludge bed, which consumed all volatile fatty acids, was maintained. A compact fouling/filtration layer formed on the filter, which contributed to low effluent chemical oxygen demand concentrations and turbidity. In addition, substrate scarcity in the filtration zone resulted in the evolution of diverse bacteria on the filter.
Additional file 2 of Attractiveness of medical disciplines amongst Swiss first-year medical students allocated to different medical education tracks: cross-sectional study
Creators: name: Markun, Stefan
name: Tandjung, Ryan
name: Rosemann, Thomas
name: Scherz, Nathalie
name: Senn, Oliver
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Supplementary file 2. Questionnaire translated in English.
Catalytically active metal organic framework based on a porphyrin modified by electron-withdrawing groups
Creators: name: Xu, Weixia
name: Zhang, Zengqi
name: Zhao, Xin
name: Li, Jun
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified

description: One metal-free porphyrin, modified by electron-withdrawing groups, was synthesized by introduction of two peripheral pyridyl substituents and two metal coordination polymers, {[Zn(C42H16F10N6)]·2C2H7 N}n (1) and {[Co(C42H16F10N6)]·C2H7 N}n (2), were synthesized solvothermally. In 1, each porphyrin connected four other porphyrin molecules to construct a 2-D network through coordination bonds. Similarly, in 2 every Co(II) porphyrin coordinated with four adjacent molecules to form a 2-D framework. Thermogravimetric analyses indicate that both 1 and 2 show high-thermal stabilities. The fluorescence data of 1 and 2 show that 1 may be a candidate for potential inorganic–organic photoactive materials. Catalytic oxidation results show that 2 displays high activity with the only product acetophenone quantitatively in 81.4%, and after six cycles, the catalytic activity slightly decreases. These features of 2, including the exceptional stability, and high catalytic activity, make it outstanding among MOFs reported in the literature.
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up
Creators: name: Yue, Han
name: Qian, Jiang
name: Yuan, Yifei
name: Zhang, Rui
name: Bi, Yingwen
name: Meng, Fengxi
name: Xuan, Yi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Medicine
Cell Biology
Biotechnology
Developmental Biology
Cancer

description: Purpose: To summarize the clinicopathological characteristics and prognosis of uveal melanoma (UM) after enucleation in Chinese patients. Methods: Between 2003 and 2012, a series of 171 patients with UM received enucleation at the Eye & ENT Hospital of Fudan University in Shanghai. Patient clinical information was collected. Pathological examination and BAP1 staining of the enucleated eyes were conducted. Univariate and multivariate Cox proportional hazard regressions were conducted to determine the risk factors, and the survival rates were calculated and compared. Results: The study included 83 (49%) men and 88 (51%) women, with a mean age of 48.6 years. The mean largest basal tumor diameter and mean largest tumor thickness were 11.8 and 8.6 mm, respectively. Ciliary body involvement was observed in 19 tumors (11%). Spindle and nonspindle patterns were observed in 100 (58%) and 71 eyes (42%), respectively. Extrascleral extension was observed in three eyes (2%). BAP1 staining was negative in 34% (53/156) of all tumors and 53% (19/36) of the cases with melanoma-related metastasis. The mean follow-up period was 63.4 months for all patients with the exception of 11 patients, who were excluded because they were lost during follow-up. A large basal tumor diameter, ciliary body involvement, nonspindle cell type, extrascleral extension, and negative BAP1 staining were associated with a worse prognosis. The survival curves significantly differed between the BAP1-negative and BAP1-positive groups (P = 0.004). According to Kaplan–Meier analysis, the 5- and 10-year metastasis-free survival rates were 80% and 70%, respectively. Conclusions: A large basal tumor diameter, ciliary body involvement, nonspindle cell type, extrascleral extension, and negative BAP1 staining may be risk factors for the prediction of the UM prognosis. A younger age at diagnosis and a similar prognosis between genders may be unique features in Asian patients compared to the Caucasian population.
IL-4Rα aptamer-liposome-CpG oligodeoxynucleotides suppress tumour growth by targeting the tumour microenvironment
Creators: name: Liu, Yu-Jie
name: Dou, Xiao-Qian
name: Wang, Fang
name: Zhang, Jing
name: Wang, Xiao-Lin
name: Xu, Gui-Li
name: Xiang, Shen-Si
name: Gao, Xin
name: Fu, Jie
name: Song, Hai-Feng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Tumour immunosuppressive microenvironments inhibit antigen-specific cellular responses and interfere with CpG-mediated immunotherapy. Overcoming tumour microenvironment (TME) immunosuppression is an important strategy for effective therapy. This study investigated the ability of a tumour-targeting IL-4Rα aptamer-liposome-CpG ODN delivery system to introduce CpG into tumours and overcome the immunosuppressive TME. The IL-4Rα-liposome-CpG delivery system was prepared. FAM-CpG visualisation was used to demonstrate tumour targeting in vitro and in vivo. Anti-tumour effects of this delivery system were evaluated in CT26 tumour-bearing mice. Mechanisms for conquering the TME were investigated. FAM-CpG was better distributed into the tumours upon treatment with IL-4Rα-liposome-FAM-CpG compared to distribution in the control group in vitro and in vivo. IL-4Rα-aptamer-liposome-CpG treatment inhibited distinct myeloid-derived suppressor cell populations in tumours and bone marrow. Similar profiles were observed for regulatory T cells in tumours. In CT26 tumour-bearing mice, IL-4Rα-liposome-CpG treatment exhibited enhanced anti-tumour activity. Increased mRNA levels of TNF-α, IL-2, and IL-12, and decreased mRNA levels of VEGF, IL-6, IL-10, MMP9, arginase-1, inducible NOS, CXCL9, p-Stat3, and NF-κB were observed in tumours upon IL-4R-liposome-CpG-treatment. The results suggested that pharmacologic targeting by the IL-4R aptamer-liposome-CpG system improves TME therapeutic benefit and provides a rationale for cancer immunotherapies.
Additional file 3 of Attractiveness of medical disciplines amongst Swiss first-year medical students allocated to different medical education tracks: cross-sectional study
Creators: name: Markun, Stefan
name: Tandjung, Ryan
name: Rosemann, Thomas
name: Scherz, Nathalie
name: Senn, Oliver
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Supplementary file 3. Scatterplot matrix for all pairs of attractiveness of career goals and importance of factors associated with career. Spearman correlation coefficients (R) and correlation test p-values are given and a correlation line is plotted. Numeric values correspond to the five-point Likert scales centring the indiscriminate answers in middle where the grid line is plotted.
Airway smooth muscle cells from ovalbumin-sensitized mice show increased proliferative response to TGFβ1 due to upregulation of Smad3 and TGFβRII
Creators: name: Shi, Jianting
name: Chen, Ming
name: Ouyang, Lihua
name: Huang, Linjie
name: Lin, Xiaoling
name: Zhang, Wei
name: Liang, Ruiyun
name: Lv, Zhiqiang
name: Liu, Shanying
name: Jiang, Shanping
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Objective: This study aimed to elucidate the role of Transforming growth factor (TGF)-β1 signaling in the proliferation of airway smooth muscle cells (ASMCs). Background: TGF-β1 is an important cytokine in airway remodeling in asthma. However, results of studies focusing on the effect of TGFβ1 on proliferation of ASMCs are controversial. Methods: An allergic model that mimics airway remodeling in chronic asthma was established and primary ASMCs were cultured. Cell proliferation was detected by viable cell counting and Cell Counting Kit (CCK)-8 analysis. Expression and phosphorylation of Smad3, type 1 TGFβ receptor (TGFβRI), type 2 TGFβ receptor (TGFβRII), extracellular signal-regulated kinase (ERK)-1/2, p38 mitogen-activated protein kinase (MAPK), C-Jun N-terminal kinase (JNK) and AKT were detected by western blot. siRNAs were used to knock down Smad3 and TGFβRII. Results: Smad3 and TGFβRII were up-regulated in primary ASMCs isolated from ovalbumin (OVA)-sensitized mice as compared with ASMCs isolated from unsensitized control mice, which persisted for at least four passages. TGFβ1 stimulated proliferation of ASMCs isolated from OVA-sensitized mice, which was inhibited by specific siRNA targeting Smad3 or TGFβRII. However ASMCs from control mice showed no proliferative response to TGFβ1. TGFβ1-induced proliferation of ASMCs from OVA-sensitized mice was markedly attenuated by PD-98059, a specific ERK1/2 inhibitor. TGFβ1 induced ERK1/2 phosphorylation within 15 minute, which was partially blocked by specific inhibitor of Smad3 (SIS3). Conclusions: ASMCs isolated from OVA-sensitized mice showed hyper-proliferation upon TGFβ1 stimulation. This might have been associated with up-regulated Smad3 and TGFβRII and mediated by ERK1/2 downstream to Smad3.