cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Основы технического дизайна
title: Учебное пособие
titleType: Subtitle
Creators: name: Бородулина С.В.
name:  Кузнецова О.Г.
name:  Решетников М.К.
Publisher: name: Вузовское образование
Year: 2019

description: В учебном пособии описаны теоретические основы технического дизайна, от формирования и развития к современному состоянию в России и за рубежом. Рассмотрены вопросы композиционной, колористической, эргономической организации дизайн-объектов, а также основные аспекты художественно-конструкторского анализа. Освещены вопросы культуры производства и методы оценки качества дизайна промышленных изделий. В пособии имеются практические задания с краткими методическими рекомендациями по выполнению. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов высших учебных заведений, обучающихся по направлениям подготовки 12.03.04 «Биотехнические системы и технологии» (профиль «Биотехнические и медицинские аппараты и системы») и 23.05.01 «Наземные транспортно-технологические средства» (специализация «Подъемно-транспортные строительные: дорожные средства и оборудование») и изучающих дисциплины «Основы технического дизайна» и «Основы дизайна транспортно-технологических машин».
Quarks, gluons, colour: Facts or fiction?
Creators: name: Buchholz, Detlev
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A general method is presented which allows one to determine from the local gauge invariant observables of a quantum field theory the underlying particle and symmetry structures appearing at the lower (ultraviolet) end of the spatio--temporal scale. Particles which are confined to small scales, i.e., do not appear in the physical spectrum, can be uncovered in this way without taking recourse to gauge fields or indefinite metric spaces. In this way notions such as quark, gluon, colour symmetry and confinement acquire a new and intrinsic meaning which is stable under gauge or duality transformations. The method is illustrated by the example of the Schwinger model.
description: 22 pages, ams-latex; the article had to be replaced because of tex problems, there are no changes in the text
Response of fibre metal laminates to blast loading
Creators: name: Shah, Syed Kamran Ayub
Publisher: name: Imperial College London
Year: 2011

description: Fibre-metal laminates (FMLs) are hybrid structures comprising interleaved metal sheets and fibre reinforced polymer composites. In this work the performance of fibre metal laminated plates under blast loading is studied numerically. The FML panels are made of alternating layers of aluminium and glass fibre/polypropylene (GFRP) with different number of layers of aluminium and composite and in the panels with equal number of layers, with different thicknesses of GFPP. The panels are subjected to global blast loading uniformly distributed over the surface of the panel and to local blast loading applied at the centre of the panel with a spatial exponential decay towards the edges. The displacements of the front and back faces are found to increase linearly with increasing impulse. The results for global blast loading are correlated with experimental results obtained by Langdon et.al [doi:10.1016/j.euromechsol.2007.09.003] and for localised blast loading with experimental studies conducted by Langdon et.al [doi:10.1016/j.ijimpeng.2006.05.008 , doi:10.1016/j.ijimpeng.2006.05.009]. A good correlation between the experimental and numerical results is found. Back face debonding is found in all the panels for both load cases. The results are also compared with the response of mild and armour steel plates having the same areal densities as FML panels. It has been shown that for the same impulse, the displacement of mild steel plate with the same areal density is approximately twice the back face displacement of FML for global blast and depends upon the thickness of mild steel plate. Therefore, for global blast loading FML performs better and can withstand higher impulses without rupture whereas mild steel plate tears apart for global blast loading and in certain cases for local blast loading. On the other hand, the displacements in armour steel are 70% to 80% of the corresponding FML panel with same areal density when subjected to global or local blast loading.
Farmers concerns in relation to organic livestock production
Creators: name: Manuelian, Carmen L.
name: Valleix, Sophie
name: Bugaut, Héloïse
name: Fuerst-Waltl, Birgit
name: da Costa, Luciana
name: Burbi, Sara
name: Schmutz, Ulrich
name: Evans, Adrian
name: Katsoulas, Nikolaos
name: Faliagka, Sofia
name: Aksoy, Uygun
name: Çiçekli, Özge
name: Dróżdż, Danuta
name: Malińska, Krystyna
name: Whistance, Lindsay
name: Johnson, Marion
name: Knebl, Lucas
name: Righi, Federico
name: De Marchi, Massimo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Molecular Biology
Pharmacology
Biotechnology
Cancer
Science Policy

description: The study describes organic producers’ perceptions of organic livestock production, product commercialisation, use of contentious inputs such as allopathic antibiotics, antiparasitics and vitamins and bedding materials availability in Mediterranean (MED) and North/Western European (NWE) countries. A total of 426 MED (46.2%) and NWE (53.8%) responses were analysed revealing more difficulty finding information on alternatives to antiparasitics and antibiotics than on bedding materials. They identified ‘feeding/nutrition’, ‘animal health’ and ‘welfare’ as the most relevant topics in their farms. Whereas ruminants and monogastrics farmers in the NWE region also indicated ‘organic regulation’ as relevant, farmers rearing ruminant species in the MED region identified farm profitability and commercialisation. Farmers still mainly relied in conventional treatments but they often applied phytotherapy, although >61% of the participants did not treat their animals in the last year. If treated, most of them administered on average one course of antibiotic treatment per animal (>62%). In the MED region, the main sources of information on alternative treatments were veterinarians (>60%) and the Internet (>32%). In the NWE region, it was other farmers for producers including ruminant species (>63%) and veterinarians (>77%) for monogastric farmers. In the NWE region, direct commercialisation and through a cooperative and/or food industry were the most frequent channel used; while, in the MED region, they were the food industry and/or direct commercialisation. In conclusion, this survey provides novel cross-European insights into organic livestock producers' concerns. A particular value of the survey is that MED countries, which are often underrepresented, were well sampled. Veterinarians were the main source of information on alternative treatmentsThe internet is gaining popularity to find information on alternative treatmentsPerceptions slightly differed between North/Western and Mediterranean countriesOrganic farmers still largely rely on conventional treatmentsPhytotherapy is gaining popularity among organic farmers Veterinarians were the main source of information on alternative treatments The internet is gaining popularity to find information on alternative treatments Perceptions slightly differed between North/Western and Mediterranean countries Organic farmers still largely rely on conventional treatments Phytotherapy is gaining popularity among organic farmers
Inhibitors of Cdc25 Phosphatases; Potential Anti-Cancer Drugs and Tools for Chemical Genetics
Creators: name: Collins, James Charles
Publisher: name: Imperial College London
Year: 2011

description: Cdc25 phosphatases play a crucial role in the regulation of the cell cycle, and overexpression of the three known isoforms has been directly correlated with poor cancer prognosis. Inhibition of this enzyme could prove to be an effective therapeutic strategy, but the most potent reported inhibitors lack specificity and an appropriate mechanism of action. Furthermore, more basic research is needed into the structure and precise cellular function of the different cdc25 isoforms. Following a literature survey, panels of novel inhibitors modelled on the natural product dysidiolide and reported quinonoid compounds were synthesised. Initial phosphatase assay results with cdc25A discouraged any further synthesis of related inhibitors. The untagged catalytic domain of each isoform was prepared, expressed and purified to carry out NMR structural studies. However, preliminary spectra showed a high degree of conformational flexibility that made further analysis prohibitively difficult. Extensive screening of crystallisation conditions also did not prove successful. As an alternative strategy, a ligand-based virtual screening approach using an optimised selection of reported inhibitors resulted in discovery of diarylthiazoles as novel, potent and drug-like inhibitors of cdc25 and the related phosphatase VHR. Some of these compounds also demonstrated potent anti-proliferative activity against a panel of cell lines. Parallel synthesis of a wide range of diarylthiazole analogues using a regioselective, sequential Pd-coupling approach proved moderately successful, identifying promising novel inhibitors for further development, although without significantly increasing the binding affinity. Screening of a wide range of commercially-available compounds chosen by a substructure analysis identified further promising inhibitors, which compare favourably with the best literature compounds. Attempts to develop novel methodology for the rapid and divergent synthesis of aminothiazoles ultimately proved unsuccessful with respect to various approaches to the difficult C-N bond formation, but simple conditions were found for the synthesis and Suzuki coupling of a highly electron-rich aminothiazole C4-triflate.
Path Integrals on Riemannian Manifolds with Symmetry and Induced Gauge Structure
Creators: name: Tanimura, Shogo
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We formulate path integrals on any Riemannian manifold which admits the action of a compact Lie group by isometric transformations. We consider a path integral on a Riemannian manifold M on which a Lie group G acts isometrically. Then we show that the path integral on M is reduced to a family of path integrals on a quotient space Q=M/G and that the reduced path integrals are completely classified by irreducible unitary representations of G. It is not necessary to assume that the action of G on M is either free or transitive. Hence our formulation is applicable to a wide class of manifolds, which includes inhomogeneous spaces, and it covers all the inequivalent quantizations. To describe the path integral on inhomogeneous space, stratification geometry, which is a generalization of the concept of principal fiber bundle, is necessarily introduced. Using it we show that the path integral is expressed as a product of three factors; the rotational energy amplitude, the vibrational energy amplitude, and the holonomy factor. When a singular point arises in $ Q $, we determine the boundary condition of the path integral kernel for a path which runs through the singularity.
description: 20 pages, no figure
A biochemical pacemaker system for robust actin growth
Creators: name: Funk, Johanna
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Cytoskeleton
subject: Actin
subject: Polymerization
subject: Profilin
subject: Formins
subject: 570
subject: 540
subject: Actin
subject: Actin-Filament

description: Eukaryotic cells determine their shape and organize their interior through a dynamic actin cytoskeleton that forms a variety of architectures, each crucial for a unique cellular function. Common to all actin structures is their growth from soluble subunits that assemble into filaments. The assembly of functional actin networks requires control over the speed at which filaments grow. How this can be realized at the high but variable concentrations of soluble actin subunits found in cells is not known. Biochemical reconstitution has singled out the concentration of soluble actin subunits as the key factor that directly controls the speed of actin growth in a linear manner. At the same time, however, this creates a paradox: The soluble actin concentration differs strongly not only between organisms, but also among distinct cell types and likely even in distinct locations within a single cell. Our current view of actin assembly posits that these large differences will result in dramatically different actin growth rates. We presently do not understand how cells deal with changes in the concentration of polymerizable actin to control filament growth. Here we develop new methods to visualize actin growth at single filament resolution over concentrations previously simply inaccessible. This puts us in the unique position to reconstitute actin assembly over the full physiological range of free subunit levels for the first time. Using this novel approach, we discover that under cell-like conditions, actin growth is not controlled by the concentration of soluble subunits. Instead, we identify a key reaction in the actin elongation cycle the release of the monomer-binding protein profilin from the filament end- as the kinetic bottleneck that limits the speed of filament growth. We show that this kinetic limit we discovered in vitro confers robustness to actin growth in the cytoplasm of mammalian cells. The fundamental finding is that this mechanism buffers the speed of actin filament growth against changes in the soluble subunit concentration, an essential requirement for the control of actin dynamics in cells. This opens a myriad of new opportunities to understand the regulation of actin dynamics and we explore the most immediate consequences. We show that the kinetic limit to actin growth imposed by profilin is not fixed but actively modulated by actin polymerases: Formin proteins, previously thought to simply increase the concentration of actin subunits at the actin filament end, catalytically promote the release of profilin from actin. This transforms our mechanistic understanding of these essential actin polymerases. In general terms, we show how the collective action of formin and profilin constitutes a molecular pacemaker system that creates robust, but tunable rates of actin growth.
Is Lavelle-McMullan transformation a really new symmetry in QED?
Creators: name: Park, D. K.
name: Kim, Hung Soo
name: Kim, Jae Kwan
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Lavelle-McMullan symmetry of QED is examined at classical and quantum levels. It is shown that Lavelle-McMullan symmetry does not give any new non-trivial information in QED by examining the Ward-Takahashi identities. Being inspired by the examination of Ward-Takahashi identity, we construct the generalized non-local and non-covariant symmetries of QED.
description: LATEX, 9 pages, two figures generated by Feynman
A method to determine the parameters of black holes in AGNs and galactic X-ray sources with periodic modulation of variability
Creators: name: Semerak, O.
name: de Felice, F.
name: Karas, V.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We propose a simple and unambiguous way to deduce the parameters of black holes which may reside in AGNs and some types of X-ray binaries. The black-hole mass and angular momentum are determined in physical units. The method is applicable to the sources with periodic components of variability, provided one can assume the following: (i) Variability is due to a star or a stellar-mass compact object orbiting the central black hole and passing periodically through an equatorial accretion disk (variability time-scale is given by the orbital period). (ii) The star orbits almost freely, deviation of its trajectory due to passages through the disk being very weak (secular); the effect of the star on the disk, on the other hand, is strong enough to yield observable photometric and spectroscopic features. (iii) The gravitational field within the nucleus is that of the (Kerr) black hole, the star and the disk contribute negligibly.
description: 17 pages, 4 figures, 2 tables; LaTeX2.09 (aas2pp4.sty); submitted to the Astrophysical Journal; also available at http://astro.mff.cuni.cz/karas/papers.htm with additional illustrations
MOESM1 of Extracellularly Extruded Syntaxin-4 Is a Potent Cornification Regulator of Epidermal Keratinocytes
Creators: name: Kadono, Nanako
name: Hagiwara, Natsumi
name: Tagawa, Takashi
name: Maekubo, Kenji
name: Hirai, Yohei
Publisher: name: figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary material, approximately 924 KB.
Thermodynamic Bethe Ansatz for N = 1 Supersymmetric Theories
Creators: name: Moriconi, M.
name: Schoutens, K.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study a series of $N\!=\!1$ supersymmetric integrable particle theories in $d=1+1$ dimensions. These theories are represented as integrable perturbations of specific $N\!=\!1$ superconformal field theories. Starting from the conjectured $S$-matrices for these theories, we develop the Thermodynamic Bethe Ansatz (TBA), where we use that the 2-particle $S$-matrices satisfy a free fermion condition. Our analysis proves a conjecture by E.~Melzer, who proposed that these $N\!=\!1$ supersymmetric TBA systems are ``folded'' versions of $N\!=\!2$ supersymmetric TBA systems that were first studied by P.~Fendley and K.~Intriligator.
description: 24 pages, Revtex
Association between biochemical parameters and ultrasonographic measurement for the assessment of hepatic lipidosis in dairy cows
Creators: name: Elshafey, Besheer G.
name: Elfadadny, Ahmed
name: Metwally, Samy
name: Saleh, Asmaa G.
name: Ragab, Rokaia F.
name: Hamada, Rania
name: Mandour, Ahmed S.
name: Hendawy, Amin Omar
name: Alkazmi, Luay
name: Ogaly, Hanan A.
name: Batiha, Gaber El-Saber
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Hepatic lipidosis (HL) is a serious metabolic disorder that affects transient high-producing dairy cows. However, there are many laboratory methods could help in the assessment of HL in dairy cows, the definite diagnosis of the disease under field conditions remains a challenge because of the non-specificity of clinical parameters. The aim of the study was to investigate the utility of serum biomarkers, and ultrasonography (US) measurement to diagnose HL in dairy cows. Forty Holstein dairy cows underwent physical examination and were divided into three groups: non-HL, mild HL, and severe HL groups based on US findings, and the concentrations of beta-hydroxybutyric acid (BHBA) and nonesterified fatty acids (NEFAs). Ultrasound images showed hyperechoic lesions and increased pixel intensity (PI) values of liver echotexture in the HL groups. A significant increase was observed in mild and severe HL groups in the activity of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), BHBA, NEFAs, malondialdehyde (MDA), and nitric oxide (NO) while the concentrations of triglyceride (TG), glutathione (GSH), and total antioxidant capacity (TAC) were significantly decreased. The classification accuracy was in the interest of NEFAs (cut off 0.62 mmol/L, sensitivity 82.6%, specificity 91.7%, and an AUC of 0.913) and BHBA (cut off 1.35 mmol/L, sensitivity 91.31%, specificity of 86.4%, and an AUC 0.812) as important diagnostic parameters. This study offers new insights into the importance of serum biochemical parameters and oxidative stress biomarkers especially, AST, NEFAs, BHBA, and GSH with the digital values of US images for prompt use of minimally invasive techniques to diagnose HL under farm conditions.HIGHLIGHTSSerum metabolites and oxidative stress indices could diagnose hepatic lipidosis in dairy cowsNEFA and BHBA concentrations and ultrasound digital values can use as a non-invasive way to the classification of hepatic lipidosis degrees in cows under farm condition. Serum metabolites and oxidative stress indices could diagnose hepatic lipidosis in dairy cows NEFA and BHBA concentrations and ultrasound digital values can use as a non-invasive way to the classification of hepatic lipidosis degrees in cows under farm condition.
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0475
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0475, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0475, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Developing a Novel Pharmacoviral Anti-Cancer Strategy Combining Targeted Immunotherapy and Oncolytic Rhabdovirus VSV∆51
Creators: name: Taha, Zaid
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2024
Subjects: Cancer immunotherapy
Cancer immunology
Oncolytic virus
Virology
Drug development
Viral engineering
Cancer biology

description: Oncolytic viruses (OVs) are attenuated viruses that have been engineered to selectively infect and kill cancer cells. OVs exert anti-tumour effects through different mechanisms that reprogram the tumour microenvironment and stimulate anti-tumour immunity. While OVs can treat many cancers, a major challenge is heterogeneity of treatment responses and tumour resistance to OV infection. To address this hurdle, the Diallo lab identified several compounds, termed viral enhancers, that improve cancer-selective OV infection and spread. These small molecules belong to multiple pharmacologic classes which impair cancer cell antiviral responses. Of note is the class of microtubule destabilizing agents (MDA), a mainstay of conventional antineoplastic chemotherapy. Although we have proven these compounds significantly improve OV efficiency, the cytotoxicity of MDAs urges improved targeting and safety. My thesis therefore centers on antibody-drug conjugate (ADC) technology which was used to deliver viral enhancing payloads to specific antigen-expressing cancer cells in combination with oncolytic vesicular stomatitis virus (VSVΔ51). We demonstrated that the clinically-approved anti-HER2 ADC, trastuzumab emtansine (T-DM1, Kadcyla®) synergizes with VSVΔ51 in HER2-positive tumours to improve overall survival and reduce tumour burden (Chapter 2). Kadcyla® consists of anti-HER2 antibody trastuzumab conjugated to a potent, viral-sensitizing MDA. To assess this pharmacoviral strategy in vivo, we engineered a novel immune-competent mouse model of human HER2+ cancer (Chapter 3). To address the issue of tumour resistance against antibody therapy through antigen absence, we designed a VSVΔ51 variant encoding the epitope of Kadcyla®: VSVΔ51-HER2T. This virus can deliver this antigen to the surface of infected cells to sensitize HER2-negative tumours to HER2-targeted therapies, including ADCs and T-cell engagers (Chapter 4). This strategy operates in a tumour agnostic fashion, independently of endogenous expression of the target antigen. Overall, we showcased the compatibility of VSV with multiple targeted combination strategies. We moreover demonstrated the efficacy of these rationally-designed combinations in multiple pre-clinical models, including in vivo disease models and ex vivo patient specimens. Importantly, our strategies culminate in a pan-cancer therapeutic approach that aims to break down clinical barriers to access to targeted therapies.
MOESM1 of Low Oxygen Tension Primes Aortic Endothelial Cells to the Reparative Effect of Tissue-Protective Cytokines
Creators: name: Heikal, Lamia
name: Ghezzi, Pietro
name: Mengozzi, Manuela
name: Ferns, Gordon
Publisher: name: figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Supplementary material, approximately 1.32 MB.
Pseudo-differential Operators on Homogeneous Spaces
Creators: name: Connolly, Donal
Publisher: name: Imperial College London
Year: 2013

description: In recent years, the use of Peter-Weyl theory (the theory of Fourier analysis on compact Lie groups) to define so-called ``global symbols'' of operators on compact Lie groups has emerged as a fruitful technique to study pseudo-differential operators. The aim of this thesis is to discuss similar techniques in the setting of compact homogeneous spaces. The approach is to relate operators on homogeneous spaces to those on compact Lie groups, and then to utilize the recently developed techniques on such groups. Two methods of associating operators on homogeneous spaces with those on compact Lie groups, called projective and horizontal lifting, along with their properties, merits and problems are considered. A key tool used in this analysis is the notion of a difference operator. This thesis includes a detailed study of such operators and their properties, combined with comprehensive calculations involving such operators on the homogeneous spaces $\Sbb^{n-1} = \SO(n)/\SO(n-1)$. This thesis concludes with a generalization of the symbolic calculus on compact Lie groups developed by M. Ruzhansky and V. Turunen together with a collection of conjectures, which if proven would relate the generalization to pseudo-differential theory on homogeneous spaces.
MOESM4 of Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8
Creators: name: Tsusaka, Takeshi
name: Kikuchi, Masaki
name: Shimazu, Tadahiro
name: Suzuki, Takehiro
name: Sohtome, Yoshihiro
name: Akakabe, Mai
name: Sodeoka, Mikiko
name: Naoshi Dohmae
name: Umehara, Takashi
name: Shinkai, Yoichi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer

description: Additional file 4: Fig. S3. Establishment of ATF7IP-rescued cell lines. Western blot analysis confirmed a comparative expression of 3xF-ATF7IP in the cell lines (related to Fig.Â 2).
High-Level Performance Estimation Framework for FPGA-based Soft Processors
Creators: name: Powell, Adam
Publisher: name: Imperial College London
Year: 2013

description: During the design of complex systems, designers need to know how their algorithm or hardware is going to perform early in the design process. Tools exist to predict performance metrics based on low-level parameters which are difficult to extract and are dependent on specific implementation or architecture details which are only available in the later stages of design. There needs to exist a model that is able to predict performance metrics based on the algorithm being executed and the architecture it is being executed on while using easily extractable parameters available early in design. This thesis introduces a framework for designers that assists them in the early stages of design. By having early estimations of performance based on the underlying hardware, greater savings can be achieved when compared to other methods which can only occur late in the design stage. Soft processors are used in the construction of the predictive models as they are flexible and allow for complex models to be created that explore the relationship between algorithm and hardware parameters. First, an accurate model for performance estimation is developed that uses both algorithm and architecture parameters. The method for extracting meaningful parameters of algorithms without the need for implementation is described and forms an important basis for this work. In predicting FPGA core power and off-chip device power, the model performs well with mean errors under 2%, while the error is slightly higher when predicting execution time. Next, a framework is proposed that uses this accurate model to analyze the performance of the algorithm in question to give the designer useful guidance not present in existing state-of-the-art approaches. The framework allows the user to see the interaction between the algorithm and the underlying hardware. This allows for early design space exploration that can produce more efficient hardware. Sensitivity analysis is performed in order to assess the performance of the proposed framework under noisy input parameters that model user uncertainty. Further, the properties of the modeling technique are used to provide the user with a measure of prediction confidence. Finally, the framework’s ability to predict the effect of single event upsets in the arithmetic hardware is examined. This is done by creating additional predictive models to examine the execution time cost in the event of faulty multipliers or dividers.
Sticky Matter: Jamming and rigid cluster statistics with attractive particle interactions
Creators: name: Koeze, Dion J.
name: Tighe, Brian P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: While the large majority of theoretical and numerical studies of the jamming transition consider athermal packings of purely repulsive spheres, real complex fluids and soft solids generically display attraction between particles. By studying the statistics of rigid clusters in simulations of soft particles with an attractive shell, we present evidence for two distinct jamming scenarios. Strongly attractive systems undergo a continuous transition in which rigid clusters grow and ultimately diverge in size at a critical packing fraction. Purely repulsive and weakly attractive systems jam via a first order transition, with no growing cluster size. We further show that the weakly attractive scenario is a finite size effect, so that for any nonzero attraction strength, a sufficiently large system will fall in the strongly attractive universality class. We therefore expect attractive jamming to be generic in the laboratory and in nature.
description: 4 pages, 5 figures
Femtosecond laser microdissection isolates regenerating C. elegans neurons for single cell RNA-sequencing
Creators: name: Zhao, Peisen
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: C. elegans
Nerve regeneration
Ultrafast laser
Single cell isolation
RNA-sequencing

description: The complexity of tissue is shaped by profound molecular diversity at a single cell level. Isolating cells of interest based on specific physiology is a crucial step to analyze its molecular underpinnings. Many cell isolation methods have been developed towards such goal. However, none is optimal when highly specific, especially rare cells are desired. For example, cell isolation by fluorescence activated cell sorting (FACS) entails tissue dissociation, which leads to a low yield (only 1 - 10% of labeled cells are collected by FACS), widespread transcriptional artifacts in isolated cells, and loss of the cells’ contextual information. Alternative methods such as laser capture microdissection (LCM) and Patch-seq have been proposed to bypass tissue dissociation, but they also suffer from numerous drawbacks, notably the degradation of cellular content. I developed a new single cell isolation method, femtosecond laser microdissection (fs-LM), to isolate intact single cells directly from living tissue or model organisms. fs-LM resects a single cell from its surrounding tissue by a series of micron-scale ablation spots, which are created by fs-laser ablation in a spherical pattern encasing the cell. I first demonstrated feasibility of fs-LM by isolating neurons of Caenorhabditis elegans and performing single cell RNA-sequencing (scRNA-seq). I achieved a yield of 32% (n = 384) and detected 2,261 ± 132 genes in single C. elegans neuron. In comparison with neurons isolated by the dissociation-FACS method, neurons isolated by fs-LM displayed reduced transcriptional artifacts induced by tissue dissociation, including up-regulation of genes involved in heat shock response and mitochondrial unfolded protein response. Existing clinical interventions to spinal cord injury have been unsatisfactory, and future development requires comprehensive knowledge of the genetic activities driving nerve regeneration. Therefore, I isolated and sequenced regenerating C. elegans neurons following fs-laser axotomy. I revealed transcriptional programs leading to successful regeneration in wild-type animals and regeneration failure in animals lacking DLK-1/p38 kinase. I further investigated the molecular basis of regeneration heterogeneity displayed by neurons of the same type, which has remained understudied despite its clinical importance. In total, 6 distinct gene modules were found to play a potential regulatory role in nerve regeneration.
Actions and symmetries of NSR superstrings and D-strings
Creators: name: Brandt, Friedemann
name: Kling, Alexander
name: Kreuzer, Maximilian
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present all NSR superstring and super-D-string actions invariant under a set of prescribed gauge transformations, and characterize completely their global symmetries. In particular we obtain locally supersymmetric Born-Infeld actions on general backgrounds in a formulation with extra target space dimensions. The nontrivial global symmetries of the superstring actions correspond to isometries of the background, whereas super-D-string actions can have additional symmetries acting nontrivially also on the coordinates of the extra dimensions.
description: 4 pages, references added and errors corrected
Word values in finite groups
Creators: name: Levy, Matthew
Publisher: name: Imperial College London
Year: 2013

description: Let w denote a group word in d variables, that is, an element of the free group of rank d. For a finite group G we may define a word map that sends a d-tuple of elements of G, to its w-value by substituting variables and evaluating the word in G by performing all relevant group operations. In this thesis we study a number of problems to do with the behaviour of word maps over various classes of groups. The first problem we look at concerns the distribution of word values in nilpotent groups. We obtain a lower bound for the probability that a random d-tuple of elements from any nilpotent group of class 2 evaluates at the identity for any fixed word in d variables answering a special case of a question of Alon Amit. Another problem we look at deals with the question of which possible subsets of a group can be obtained as the image of a word map. This was first studied by Kassabov & Nikolov and later by Lubotzky who gave a complete description in the case of simple groups. We obtain a partial classification for the almost simple groups and quasisimple groups and completely describe what happens in the case of symmetric groups. Finally, we study twisted commutator maps over the alternating groups, special linear groups and special unitary groups. Twisted commutators are similar to commutators but are twisted by group automorphisms. These have been studied by Nikolov & Segal in where they obtain bounds on the width of twisted commutator words over the finite quasisimple groups. Our goal is to improve these bounds. Throughout this thesis we will also look at variations of the above problems as well as related questions.
Coherently strained epitaxial YBa$_2$Cu$_3$O$_{7-δ}$ films grown on NdGaO$_3$ (110)
Creators: name: Khanof, Sogol
name: Mannhart, Jochen
name: Boschker, Hans
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: YBa$_2$Cu$_3$O$_{7-δ}$ is a good candidate to systematically study high-temperature superconductivity by nanoengineering using advanced epitaxy. An essential prerequisite for these studies are coherently strained YBa$_2$Cu$_3$O$_{7-δ}$ thin films, which we present here using NdGaO$_3$ (110) as a substrate. The films are coherent up to at least 100 nm thickness and have a critical temperature of 89$\pm$1 K. The $a$ and $b$ lattice parameters of the YBa$_2$Cu$_3$O$_{7-δ}$ are matched to the in-plane lattice parameters of NdGaO$_3$ (110), resulting in a large reduction of the orthorhombicity of the YBa$_2$Cu$_3$O$_{7-δ}$. These results imply that a large amount of structural disorder in the chain layers of YBa$_2$Cu$_3$O$_{7-δ}$ is not detrimental to superconductivity.
description: Accepted for publication in Applied Physics Letters
Oral history interview with Lynn R. Sykes 1997
Publisher: name: Columbia University
Year: 2019

description: Childhood: born Pittsburgh, Pennsylvania, son of meteorologist; early education in Fairfax County, Virginia; Massachusetts Institute of Technology: B.S., M.S., geology, geophysics, 1955-1960; U.S. Geological Survey: pressure research, summer, 1956; Woods Hole Oceanographic Institute: geophysical research in Europe, at sea, 1959-1960; Lamont-Doherty Earth Observatory [LDEO]: PhD., geophysics 1960-1965, restructuring of LDEO, Columbia administration, member, executive committee of LDEO, 1968, fundraising issues, succession of LDEO directors; seismological research in California, East Africa, Greenland, South Pacific, Fiji, Japan; funding of research projects; development of seismological instrumentation; introduction of computers into recording of seismological data; development of continental drift theory, transform faulting, plate tectonics; Columbia University: assistant professorship, geology, formation of Department of Earth and Environmental Sciences; effort to improve environmental science curriculum, job availability; Columbia acquisition of Biosphere II: opposition to management, curriculum; involvement in nuclear test ban: development of instrumentation and stations, Threshold Test Ban Treaty testimony for Senate, 1972, visits to China, Russia, collaboration with Russia and American intelligence, controversy over use of Soviet weapons; earthquake prediction for Environmental Science Services Administration, 1966-1968; personal development through psychoanalysis; earthquake prediction, 1965-present: collaboration with Russian, Japanese seismologists, prediction in New England, New York, California, Alaska; member, Predictive Evaluation Council, 1979-1982; chairman, National Earthquake Prediction Council, 1984-1988; formation of Southern California Earthquake Center, 1991; Indian Point Nuclear Reactor: testimony to New York State, 1976; reminiscences of colleagues.
Wave transport in parity-time symmetric, time-varying, and quasi-periodic systems
Creators: name: Xiao, Zhicheng, 1987-
name: 0000-0002-9027-3058
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Non-Hermitian physics
PT-symmetry
Time modulation
Quasi-periodicity
Wave scattering

description: The past several decades have witnessed a rapid growth of research interest in the fields of artificial materials and systems, in particular in the areas of parity-time symmetric systems, time-varying systems and quasi-periodic systems. These newly developed material platforms have been enabling many exotic wave-matter interaction phenomena unavailable in nature. In this context, I investigated a series of wave transport and scattering phenomena in parity-time symmetric, time-varying and quasi periodic systems in this dissertation. First, I proposed a sensing circuit based on sixth-order exceptional point (EP), which supports high sensitivity, resolution, and nondegraded thermal noise performance compared with conventional diabolic point (DP) sensing system. I also studied the influence of thermal noise in a general two-level sensing platform based on EP. Second, I demonstrated a robust microwave tunneling device operating in the extreme case in which the transmission channel is shorted through a small reactance. We observed full restoration of information and overall transparency to an external observer through use of a pair of parity-time-symmetric emitter and absorber. Third, I studied the effects of realistic switching parameters and synchronization in a series of nonreciprocal devices based on synchronized loss modulation. The research showed that the nonreciprocal response of these systems experiences a linear regression of insertion loss and isolation with respect to the timing error among switches. Remarkably, impedance matching, and nonreciprocal phase shifts are immune from synchronization issues, and reasonable levels of synchronization errors still guarantee low insertion loss and good isolation. Fourth, I studied wave scattering phenomena in static and dynamic quasi-periodic LC resonator array, which provides an easily accessible and reconfigurable platform to study fractal energy band and topological edge state. Overall, my explorations have been enabling a new degree of control of waves in circuits and metamaterials, pushing forward the opportunities for extreme wave-matter interactions using gain and time modulations.
Effects of dietary chitosan oligosaccharides supplementation on meat quality, chemical composition and anti-oxidant capacity in frizzled chickens
Creators: name: Lan, Ruixia
name: Chen, Xiaochun
name: Zhang, Yuhua
name: Luo, Huiwen
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The aim of this study was to evaluate dietary chitosan oligosaccharides (COS) supplementation on meat quality, chemical composition and oxidative stability in frizzled chickens. A total of 360 one-day-old female frizzled chickens with an average body weight of 34.38 ± 1.23 g were randomly allocated to four groups with six replications (10 chickens/replication) in this 84-day experiment. The chickens in the control group (CON) fed the basal diet and the other three experimental diets were based on the basal diet with 300, 600 and 900 mg/kg COS supplementation, respectively. The results indicated that dietary COS increased growth performance, eviscerated and breast muscle yield while decreased abdominal fat yield, accompanied with increasing pH45min, pH24h, Lightness, drip loss and cooking loss in breast and thigh muscle. The scavenging activity of 2,2-diphenyl-1-picrylhydrazyl, superoxide radical, hydroxyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt, the activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) in breast and thigh muscle were improved by COS while malondialdehyde content was decreased. COS up-regulated the gene expression of nuclear factor erythroid 2-related factor 2, heme oxygenase-1, NAD(P)H quinone dehydrogenase 1, SOD, CAT and GSH-Px in breast and thigh muscle. In conclusion, dietary COS supplementation improved meat quality by improving pH, colour, water holding capacity and anti-oxidant capacity, accompanied with decreased lipid metabolism in frizzled chickens. Dietary 600 mg/kg COS was recommended in frizzled chickens’ diet to improve meat quality.HighlightsCOS improves growth performance of frizzled chickens.COS improves meat quality of frizzled chickens.COS enhances anti-oxidant capacity of frizzled chickens’ meat. COS improves growth performance of frizzled chickens. COS improves meat quality of frizzled chickens. COS enhances anti-oxidant capacity of frizzled chickens’ meat.
Functional Differential Equations for the Free Energy and the Effective Energy in the Broken-Symmetry Phase of phi^4-Theory and Their Recursive Graphical Solution
Creators: name: Pelster, A.
name: Kleinert, H.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Extending recent work on QED and the symmetric phase of the euclidean multicomponent scalar ϕ^4-theory, we construct the vacuum diagrams of the free energy and the effective energy in the ordered phase of ϕ^4-theory. By regarding them as functionals of the free correlation function and the interaction vertices, we graphically solve nonlinear functional differential equations, obtaining loop by loop all connected and one-particle irreducible vacuum diagrams with their proper weights.
description: Author Information under http://www.physik.fu-berlin.de/~kleinert/institution.html Latest update of paper also at http://www.physik.fu-berlin.de/~kleinert/310