cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prolonged elevation of serum neurofilament light after concussion in male Australian football players
Creators: name: McDonald, Stuart
name: WT O’Brien
name: GF Symons
name: Z Chen
name: J Bain
name: BP Major
name: D Costello
name: G Yamakawa
name: M Sun
name: RD Brady
name: B Mitra
name: R Mychasiuk
name: TJ O’Brien
name: SR Shultz
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021, The Author(s). Background: Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and diagnostic ability of serum levels of neurofilament light (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), glial fibrillary acidic protein (GFAP), and tau in concussed male and female Australian footballers. Methods: Blood was collected from 28 Australian rules footballers (20 males, 8 females) at 2-, 6-, and 13-days after a diagnosed concussion for comparison to their levels at baseline (i.e. pre-season), and with 27 control players (19 males, 8 females) without a diagnosis of concussion. Serum concentrations of protein markers associated with damage to neurons (UCHL1), axons (NfL, tau), and astrocytes (GFAP) were quantified using a Simoa HD-X Analyzer. Biomarker levels for concussed players were compared over time and between sex using generalised linear mixed effect models, and diagnostic performance was assessed using area under the receiver operating characteristic curve (AUROC) analysis. Results: Serum NfL was increased from baseline in male footballers at 6- and 13-days post-concussion. GFAP and tau were increased in male footballers with concussion at 2- and 13-days respectively. NfL concentrations discriminated between concussed and non-concussed male footballers at all time-points (AUROC: 2d = 0.73, 6d = 0.85, 13d = 0.79), with tau also demonstrating utility at 13d (AUROC = 0.72). No biomarker differences were observed in female footballers after concussion. Conclusions: Serum NfL may be a useful biomarker for the acute and sub-acute diagnosis of concussion in males, and could inform neurobiological recovery and return-to-play decisions. Future adequately powered studies are still needed to investigate biomarker changes in concussed females.
Outside the box; Specimens of the Malacology Department, at Harvard's Museum of Comparative Zoology
Creators: name: Trimble, Jennifer
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Outside the box; Specimens of the Malacology Department, at Harvard's Museum of Comparative Zoology by Jennifer Trimble of Harvard Mcz United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Additional file 2 of Educational training to improve opioid overdose response among health center staff: a quality improvement initiative
Creators: name: Stephenson, Audrey
name: Calvo-Friedman, Alessandra
name: Altshuler, Lisa
name: Zabar, Sondra
name: Hanley, Kathleen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Additional file 2. Feedback survey.
Clinical spasticity assessment using the Modified Tardieu Scale does not reflect joint angular velocity or range of motion during walking: Assessment tool implications
Creators: name: M Banky
name: RA Clark
name: Mentiplay, Benjamin
name: JH Olver
name: G Williams
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: OBJECTIVE: Spasticity assessment is often used to guide treatment decision-making. Assessment tool limitations may influence the conflicting evidence surrounding the relationship between spasticity and walking. This study investigated whether testing speeds and joint angles during a Modified Tardieu assessment matched lower-limb angular velocity and range of motion during walking. DESIGN: Observational study. SUBJECTS: Thirty-five adults with a neurological condition and 34 assessors. METHODS: The Modified Tardieu Scale was completed. Joint angles and peak testing speed during V3 (fast) trials were compared with these variables during walking in healthy people, at 0.400.59, 0.600.79 and 1.401.60 m/s. The proportion of trials in which the testing speed, start angle, and angle of muscle reaction matched the relevant joint angles and angular velocity during walking were analysed. RESULTS: The Modified Tardieu Scale was completed faster than the angular velocities seen during walking in 88.7% (0.400.59 m/s), 78.9% (0.600.79 m/s) and 56.2% (1.401.60 m/s) of trials. When compared with the normative dataset, 4.2%, 9.5% and 13.7% of the trials met all criteria for each respective walking speed. CONCLUSION: When applied according to the standardized procedure and compared with joint angular velocity during walking, clinicians performed the Modified Tardieu Scale too quickly.
Endo-fenchyl acetate rich essential oil of Strobilanthes sessilis Nees inflorescence and its characterisation using GC, GC-MS, and NMR techniques
Creators: name: Sharma, Pranav Murali
name: Krishnamoorthy, Devanathan
name: Bhukya, Balakishan
name: Sundaresan, Velusamy
name: Pragadheesh, V. S.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Strobilanthes Blume is a genus in the family Acanthaceae, with many species endemic to the Indian subcontinent. Strobilanthes sessilis Nees is endemic to the southern Western Ghats of India. The essential oil of dried inflorescence of S. sessilis was extracted using hydrodistillation method and the chemical composition was determined using GC and GC-MS techniques, which revealed the major compound to be endo-fenchyl acetate (89.33%). Other minor compounds like endo-fenchol (3.74%), (E)-caryophyllene (1.07%), and limonene and β-phellandrene (0.55%) were also observed. The major diastereomer of fenchyl acetate was determined using 2D-NMR techniques like HSQC, HMBC, and ROESY to confirm the endo configuration. The optical rotation of the oil in different solvents deduced that the laevorotatory enantiomer of endo-fenchyl acetate as the major or single compound. S. sessilis could be further explored as a major source of endo-fenchyl acetate, which has high importance in flavouring and other biological applications.
Seroconversion of Hepatitis B Vaccine in Young Children in Kwadaso District of Ghana.
Creators: name: Afriyie, Nathaniel
name: Visser, Lucas A.
name: Kwabena O. Boateng
name: Awuah, Anthony A. A.
name: Yeboah, Francis A.
name: Tetteh, Joseph
Publisher: name: Prof. Samuel Sakyi.
Year: 2023

description: This study evaluated seroconversion and seroprotection status of children in the Kwadaso District of Ghana, and it's a cross-sectional study.
description: 1.1. Background Hepatitis B Virus (HBV) infection is an important public health problem that requires high priority efforts towards prevention and control. Active immunization is the single most important and effective preventive measure against HBV infection. As a protective measure, Ghana—after introducing the mass immunization program against hepatitis B infection in children in 2002—continued her Expanded Programme on Immunization (EPI) in 2019. This study evaluated seroconversion (the point in time when the amount of antibody in the blood becomes detectable) and seroprotection (the point in time when the amount of antibody in the blood is enough to confer protection from the antigen that induced it production) status of children under this mass immunization program and measured their antibody levels four years after immunization. 1.2. Materials and Method 220 archived plasma samples of children between the ages of 1–10 years were retrieved from a previous cross-sectional study by researchers from KCCR between 2010 and 2014. Of these, 105 have completed the EPI and were screened for HBsAg. Those found to be HBsAg-seronegative were stratified into three groups according to their age at which the last vaccine was administered. Their anti-HBsAg titer levels were estimated by enzyme linked immunosorbant assay (ELISA). 1.3. Results Four (1.9%) samples were HBsAg seropositive and were excluded from further analyses. 9 more samples were excluded from analyses because they were insufficient. The anti-HBs titers recorded ranged from 1.021 IU/L to 751.64 IU/L indicating a 100% seroconversion rate. In group one (0–6 months), 87.9% were seroprotected. Group two (2-3yrs) had 78.3% seroprotection and group three (3-5yrs) had 41.7% seroprotection. There was no significant difference between group 1 and 2. However, there was a significant difference between group 1 and 3 (p = 0.0137) and between group 2 and 3 (p = 0.0390) respectively. There was no significant difference between male and female children. 1.4. Conclusion All the children who received doses of hepatitis B vaccine at 6, 10 and 14 weeks in the immunization program seroconverted, but their levels of protection waned with increasing years. Booster doses are therefore recommended after 5 years.
EXC_Supplement_Final – Supplemental material for Examining Longitudinal Patterns of Special Education Service Receipt
Creators: name: Woods, Adrienne D.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, EXC_Supplement_Final for Examining Longitudinal Patterns of Special Education Service Receipt by Adrienne D. Woods in Exceptional Children
Additional file 1 of Validating field regeneration capacity for selected accessions of Gossypium hirsutum using callus induction and regeneration capacity
Creators: name: TAJO, Sani Muhammad
name: PAN, Zhaoe
name: HE, Shoupu
name: JIA, Yinhua
name: MAHMOOD, Tahir
name: NAZIR, Mian Fasil
name: HU, Daowu
name: WANG, Liru
name: SADAU, Salisu Bello
name: IBRAHIM, Sani
name: AUTA, Umar
name: GENG, Xiaoli
name: DU, Xiongming
Publisher: name: figshare
Year: 2024
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Tables 1. The passport information of germlasm used in this study.
Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases
Creators: name: JG Williams
name: D Ly
name: NJ Geraghty
name: JD McArthur
name: HKN Vyas
name: J Gorman
name: Tsatsaronis, James
name: R Sluyter
name: ML Sanderson-Smith
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2021 Williams, Ly, Geraghty, McArthur, Vyas, Gorman, Tsatsaronis, Sluyter and Sanderson-Smith. Invasive infections due to group A Streptococcus (GAS) advance rapidly causing tissue degradation and unregulated inflammation. Neutrophils are the primary immune cells that respond to GAS. The neutrophil response to GAS was characterised in response to two M1T1 isolates; 5448 and animal passaged variant 5448AP. Co-incubation of neutrophils with 5448AP resulted in proliferation of GAS and lowered the production of reactive oxygen species when compared with 5448. Infection with both strains invoked neutrophil death, however apoptosis was reduced in response to 5448AP. Both strains induced neutrophil caspase-1 and caspase-4 expression in vitro, with inflammatory caspase activation detected in vitro and in vivo. GAS infections involving strains such as 5448AP that promote an inflammatory neutrophil phenotype may contribute to increased inflammation yet ineffective bacterial eradication, contributing to the severity of invasive GAS infections.
Phytochemical constituents, ferric reducing and radical scavenging activities of helichrysm caespititium
Creators: name: Mfengwana, Polo-Ma-Abiele H.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Helichrysm caespititium is used for the treatment of viral infections and respiratory ailments. This study aimed to determine the phytochemical constituents and antioxidants (using ABTS, DPPH and FRAP) of H. caespititium water and methanol extracts. The phytochemical analysis revealed the presence of flavonoids, phytosterols, tannins, glycosides etc. Whilst the alkaloids were absent. Quantitative analysis of total phenols using both methanol and water extracts yielded high values of (839,1 and 531) GA/mg indicating rich phytochemical constituents from this plant. Whilst flavonoids from methanol and water extracts yielded (324 and 58) mg GA/mg, respectively. Results obtained from FRAP water and methanol extracts were 20,42% and 2,36% respectively; DPPH water and methanol extracts results were 92,62% and 80,56% respectively; and ABTS water and methanol extracts were 93,64% and 97,68%, respectively. These findings support the potential of H. caespititium as the potential source for the development of antioxidant-based therapies and health-promoting products.
EC_Supplemetal_Material_Table_S1_201021 – Supplemental material for The Effects of Tier 2 Mathematics Interventions for Students With Mathematics Difficulties: A Meta-Analysis
Creators: name: Jitendra, Asha K.
name: Alghamdi, Ahmed
name: Edmunds, Rebecca
name: McKevett, Nicole M.
name: Mouanoutoua, John
name: Roesslein, Rachel
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, EC_Supplemetal_Material_Table_S1_201021 for The Effects of Tier 2 Mathematics Interventions for Students With Mathematics Difficulties: A Meta-Analysis by Asha K. Jitendra, Ahmed Alghamdi, Rebecca Edmunds, Nicole M. McKevett, John Mouanoutoua and Rachel Roesslein in Exceptional Children
Bezzia Kieffer 1899
Creators: name: Borkent, Art
name: Evenhuis, Neal L.
name: Dominiak, Patrycja
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ceratopogonidae
Bezzia

description: Genus BEZZIA Kieffer
breidenbaughi Huerta, Spinelli & Grogan, 2023: 543. Mexico (Mexico).
trujilloi Huerta, Spinelli & Grogan, 2023: 540. Mexico (Veracruz).
description: Published as part of Borkent, Art, Evenhuis, Neal L. & Dominiak, Patrycja, 2025, The World Catalog of Biting Midges (Diptera: Ceratopogonidae): Additional Updates and Errata, pp. 245-268 in Zootaxa 5631 (2) on page 261, DOI: 10.11646/zootaxa.5631.2.2, http://zenodo.org/record/15370558
Partnering with scholars in the digital humanities to link an historic regional herbarium with its original collection and accession records.
Creators: name: Weeks, Andrea
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Partnering with scholars in the digital humanities to link an historic regional herbarium with its original collection and accession records. by Herbiarum Director & Associate Professor Andrea Weeks of Herbiarum Director & Associate Professor George Mason University Fairfax United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Supp_Materials – Supplemental material for Winter Maintenance of Permeable Interlocking Concrete Pavement: Evaluating Opportunities to Reduce Road Salt Pollution and Improve Winter Safety
Creators: name: Marvin, Jeffrey T.
name: Scott, Jody
name: Seters, Tim Van
name: Bowers, Robert
name: Drake, Jennifer Anne
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, Supp_Materials for Winter Maintenance of Permeable Interlocking Concrete Pavement: Evaluating Opportunities to Reduce Road Salt Pollution and Improve Winter Safety by Jeffrey T. Marvin, Jody Scott, Tim Van Seters, Robert Bowers and Jennifer Anne Drake in Transportation Research Record
Moonlighting proteins shine new light on molecular signaling niches
Creators: name: Turek, Ilona
name: Irving, Helen
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Plants as sessile organisms face daily environmental challenges and have developed highly nuanced signaling systems to enable suitable growth, development, defense, or stalling re-sponses. Moonlighting proteins have multiple tasks and contribute to cellular signaling cascades where they produce additional variables adding to the complexity or fuzziness of biological sys-tems. Here we examine roles of moonlighting kinases that also generate 3’,5’-cyclic guanosine monophosphate (cGMP) in plants. These proteins include receptor like kinases and lipid kinases. Their guanylate cyclase activity potentiates the development of localized cGMP-enriched nanodomains or niches surrounding the kinase and its interactome. These nanodomains contribute to allosteric regulation of kinase and other molecules in the immediate complex directly or indirectly modulating signal cascades. Effects include downregulation of kinase activity, modulation of other members of the protein complexes such as cyclic nucleotide gated channels and potential triggering of cGMP-dependent degradation cascades terminating signaling. The additional layers of information provided by the moonlighting kinases are discussed in terms of how they may be used to provide a layer of fuzziness to effectively modulate cellular signaling cascades.
Additional file 2 of Validating field regeneration capacity for selected accessions of Gossypium hirsutum using callus induction and regeneration capacity
Creators: name: TAJO, Sani Muhammad
name: PAN, Zhaoe
name: HE, Shoupu
name: JIA, Yinhua
name: MAHMOOD, Tahir
name: NAZIR, Mian Fasil
name: HU, Daowu
name: WANG, Liru
name: SADAU, Salisu Bello
name: IBRAHIM, Sani
name: AUTA, Umar
name: GENG, Xiaoli
name: DU, Xiongming
Publisher: name: figshare
Year: 2024
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 2: Supplementary Table 2. Correlation analysis of ten phenotypic and physiological traits.
Prime Resonance Identity
Creators: name: Bostick, Devin
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Systems Theory
subject: Complex Systems
subject: Structured Emergence
subject: Structured Resonance
subject: Prime Number Theory
subject: Human Identity
subject: Phase Coherence
subject: CODES Framework
subject: Distributed Intelligence
subject: Recursive Systems
subject: Phase Alignment Score (PAS)
subject: AGI Architecture
subject: Symbolic Collapse

description: Main article

Abstract

This paper proposes a foundational shift in how human identity, emergence, and intelligence are modeled. Rather than viewing individuals as symbolic agents embedded in sociocultural hierarchies, we frame each human as a prime-indexed chiral node—denoted as Cₙ—within a dynamic swarm lattice. These nodes are not defined by traits, narratives, or categories, but by their structural role in the resonance architecture of emergence.

Drawing from the CODES framework (Chirality of Dynamic Emergent Systems), we establish that identity is not a static label, but a structural function—a unique entry point in the recursive lattice of intelligence. Each Cₙ maps to a specific resonance archetype (e.g., Translator, Mirror, Resonance Architect), which governs how a node interacts with the field, what kinds of coherence it can generate, and what emergence pathways it can unlock.

Emergence itself is defined not by aggregation, but by relative coherence between nodes. Using the metric PAS (Phase Alignment Score), we model emergence events as phase-locking interactions between prime nodes: E(x, y) = PAS(Cₓ ↔ Cᵧ). High coherence between structurally distinct primes produces intelligence, innovation, and social synchronization. Low PAS yields fragmentation, noise, or collapse.

This prime-indexed identity framework redefines how we approach education, governance, collaboration, and artificial intelligence. It provides a rigorous, generative alternative to symbolic identity models—one that preserves individuality while enabling scalable coherence. The result is a unified substrate for understanding emergence across humans, machines, and systems: not through probability, but through structured resonance.
Additional file 1 of Eculizumab for paroxysmal nocturnal haemoglobinuria: catastrophic health expenditure in Nepalese patients
Creators: name: Adhikari, Sugat
name: Sapkota, Surendra
name: Shrestha, Suraj
name: Karki, Kshitiz
name: Shrestha, Anjan
Publisher: name: figshare
Year: 2024
Subjects: subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Astonishing emulsifying properties of a novel exopolysaccharide produced from Bacillus velezensis BABA50
Creators: name: Boumaza, Khedidja
name: Marir, Rafik
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Microbial exopolysaccharides (EPSs) are currently under intensive research in various applications. However, studies on EPS from Bacillus velezensis are rare and the emulsifying properties of this EPS have not been studied previously. An EPS produced by a novel B. velezensis BABA50 strain isolated from an Algerian hot spring was characterised. The results of structural, morphological and thermal analyses showed a heteropolymeric structure containing galactose, glucose, glucuronic acid and N-acetyl glucosamine. Analyses revealed the presence of carbonyl and hydroxyl groups, branched and highly porous structure and relevant thermal stability compared to other EPSs with a high degradation temperature of 260 °C and 38% of residual mass at 800 °C. EPS from B. velezensis BABA50 presents distinct polymer in terms of structure and composition compared to previously described EPS with excellent emulsifying and antioxidant activities; this EPS holds great potential in the food and cosmetic industries as a thermostable emulsifier and antioxidant agent.
Detection of bacterial membrane vesicles by NOD-like receptors
Creators: name: Johnston, Ella
name: Begona Heras
name: TA Kufer
name: Liaskos, Maria
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Bacterial membrane vesicles (BMVs) are nanoparticles produced by both Gram-negative and Gram-positive bacteria that can function to modulate immunity in the host. Both outer membrane vesicles (OMVs) and membrane vesicles (MVs), which are released by Gram-negative and Gram-positive bacteria, respectively, contain cargo derived from their parent bacterium, including immune stimulating molecules such as proteins, lipids and nucleic acids. Of these, peptidoglycan (PG) and lipopolysaccharide (LPS) are able to activate host innate immune pattern recognition receptors (PRRs), known as NOD-like receptors (NLRs), such as nucleotide-binding oligomerisation domain-containing protein (NOD) 1, NOD2 and NLRP3. NLR activation is a key driver of inflammation in the host, and BMVs derived from both pathogenic and commensal bacteria have been shown to package PG and LPS in order to modulate the host immune response using NLR-dependent mechanisms. Here, we discuss the packaging of immunostimulatory cargo within OMVs and MVs, their detection by NLRs and the cytokines produced by host cells in response to their detection. Additionally, commensal derived BMVs are thought to shape immunity and contribute to homeostasis in the gut, therefore we also highlight the interactions of commensal derived BMVs with NLRs and their roles in limiting inflammatory diseases.
Past and Present Teaching: Returning to the Cole Museum of Zoology's original function as a university-level teaching resource, by developing a new museum space and enabling undergraduate students to safely undertake remedial conservation work within our fluid-preserved collections.
Creators: name: Smith, Claire
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Past and Present Teaching: Returning to the Cole Museum of Zoology's original function as a university-level teaching resource, by developing a new museum space and enabling undergraduate students to safely undertake remedial conservation work within our fluid-preserved collections. by Claire Smith of Cole Museum Of Zoology, University Of Reading Reading United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Cytotoxic metabolites from the mangrove endophytic fungus Aspergillus sp. GXNU QG1a
Creators: name: Bo, Xianglong
name: Zhao, Yufei
name: Qin, Feng
name: Wu, Furong
name: Tan, Meijing
name: Ju, Shichao
name: Song, Zishuo
name: Li, Wenjun
name: He, Fan
name: Wei, Youquan
name: Xu, Hua
name: Huang, Xishan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: A new benzoquinone, guxiumasperone A (1), and a new diisoprenyl-cyclohexene-type meroterpenoids, biscognienyne M (2), along with four known diisoprenyl-cyclohexene analogues was isolated from the mangrove endophytic fungus Aspergillus QG1a. Their structures were determined by extensive spectral analysis of 1D and 2D NMR, HR-ESI- MS, and X-ray crystallography. Compound 1 was deduced by a single-crystal X-ray diffraction analysis, and the absolute configuration of 2 was further unequivocally elucidated by comparing the experimental electronic circular dichroism (ECD) data with calculated ECD spectra. Compounds 1 and 2 showed significant cytotoxic activity against selected tumour cells. Particularly, compound 2 exhibited strong activity against A2780 cancer cells with an IC50 value of 6.8 μM.
Molecular properties, structure and chiral resolution of secondary metabolites from the leaves of Viburnum chingii
Creators: name: La, Chang-Sheng
name: Lv, Tian-Ming
name: Liang, Jing-Jing
name: Xu, Zhi-Yong
name: Huang, Xiao-Xiao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: A chemical investigation of leaves of Viburnum chingii afforded eleven compounds, including one undescribed lignan (1), a pair of known phenylpropanoid enantiomers (2a/2b), and eight known lignans (3-10). Their structures were elucidated by detailed spectroscopic and comparative literature data analysis. The absolute configurations of compounds 1 was determined by comparing the experimental ECD data with the calculated values. The compounds 2a/2b were separated successfully by a chiral chromatographic column. In addition, the acetylcholinesterase (AChE) inhibitory activities of described compounds were evaluated.
The chemical composition of the essential oils of two Mediterranean species of Convolvulaceae: Convolvulus althaeoides subsp. tenuissimus collected in Sicily (Italy) and Calystegia silvatica collected in Algeria
Creators: name: Derbak, Larbi
name: Vaglica, Alessandro
name: Badalamenti, Natale
name: Porrello, Antonella
name: Ilardi, Vincenzo
name: Rebbas, Khellaf
name: Hamdi, Bendif
name: Bruno, Maurizio
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Convolvulus L. and Calystegia R.Br. are two closely related genera of the Convolvulaceae family distributed in Asia, Mediterranean, Macaronesia, East Africa, and Arabia, including about 210 and 30 accepted species, respectively, of flowering plants, present as trees, shrubs, and herbs. The ethnomedical use of Convolvulus species dates to 1730s as they displayed profuse medicinal properties. In the present study, the not previously investigated chemical compositions of the essential oils from aerial parts of Convolvulus althaeoides subsp. tenuissimus (Sm.) Bat., collected in Sicily, and Calystegia sylvatica (Kit.) Griseb., collected in Algeria, were evaluated by GC-MS. The main components of the essential oil of the first one were β-caryophyllene (28.68%), γ-muurolene (23.75%), and γ-elemene (17.55%), whereas the C. silvatica essential oil was shown to be rich of valeranone (10.77%), viridiflorol (9.45%), and germacrene D (8.61%). Furthermore, a complete literature review on the ethno-pharmacological uses of Convolvulus and Calystegia species was performed.
Pathologies associated with the Osteological Collection of the Natural History and Science Museum of the University of Porto
Creators: name: Perestrelo, Sofia
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Pathologies associated with the Osteological Collection of the Natural History and Science Museum of the University of Porto by Sofia Perestrelo of Museu De História Natural Do Porto Porto Portugal for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
A Pipeline towards the Biochemical Characterization of the Arabidopsis GT14 Family
Creators: name: L Xuan
name: J Zhang
name: W Lu
name: P Gluza
name: B Ebert
name: T Kotake
name: M Lu
name: Y Zhang
name: MH Clausen
name: Johnson, Kim
name: Doblin, Monika
name: JL Heazlewood
name: Bacic, Tony
name: Song, Lili
name: W Zeng
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Glycosyltransferases (GTs) catalyze the synthesis of glycosidic linkages and are essential in the biosynthesis of glycans, glycoconjugates (glycolipids and glycoproteins), and glycosides. Plant genomes generally encode many more GTs than animal genomes due to the synthesis of a cell wall and a wide variety of glycosylated secondary metabolites. The Arabidopsis thaliana genome is predicted to encode over 573 GTs that are currently classified into 42 diverse families. The biochemical functions of most of these GTs are still unknown. In this study, we updated the JBEI Arabidopsis GT clone collection by cloning an additional 105 GT cDNAs, 508 in total (89%), into Gateway-com-patible vectors for downstream characterization. We further established a functional analysis pipeline using transient expression in tobacco (Nicotiana benthamiana) followed by enzymatic assays, fractionation of enzymatic products by reversed-phase HPLC (RP-HPLC) and characterization by mass spectrometry (MS). Using the GT14 family as an exemplar, we outline a strategy for identify-ing effective substrates of GT enzymes. By addition of UDP-GlcA as donor and the synthetic accep-tors galactose-nitrobenzodiazole (Gal-NBD), β-1,6-galactotetraose (β-1,6-Gal4) and β-1,3-galacto-pentose (β-1,3-Gal5) to microsomes expressing individual GT14 enzymes, we verified the β-glucu-ronosyltransferase (GlcAT) activity of three members of this family (AtGlcAT14A, B, and E). In ad-dition, a new family member (AT4G27480, 248) was shown to possess significantly higher activity than other GT14 enzymes. Our data indicate a likely role in arabinogalactan-protein (AGP) biosyn-thesis for these GT14 members. Together, the updated Arabidopsis GT clone collection and the biochemical analysis pipeline present an efficient means to identify and characterize novel GT catalytic activities.
Three new flavonoid glycosides isolated from Pteridium aquilinum
Creators: name: Lu, Weiren
name: Wang, Shaojun
name: Xiong, Yanfen
name: Liu, Jianqun
name: Shu, Jicheng
name: Yan, Yongxin
name: Peng, Caiying
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Three new flavonoid glycosides, (S)-4′,6,8-trihydroxyflavanone-7-C-glucoside (1), (R)-4′,6,8- trihydroxyflavanone-7-C-glucoside (2) and distenin-7-O-β-D-glucoside (3), along with nine known flavonoids (4-12) were isolated from the aerial of Pteridium acquilinum. Their structures were elucidated by the analysis of spectroscopy data and their comparison with the reported values. The two C-glycosyl flavanones (1 and 2), were isolated from this specie, which might be chemotaxonomic markers of this specie. In addition, three new flavonoids were preliminarily examined for their anti-inflammatory activity. Compounds 1-3 inhibited the NF-κB induction by 46.3%, 59.6% and 29.2%, respectively.
Additional file 5 of Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients
Creators: name: Tornesello, Anna Lucia
name: Botti, Chiara
name: Micillo, Alberto
name: Labonia, Francesco
name: Arpino, Sergio
name: Isgrò, Maria Antonietta
name: Meola, Serena
name: Russo, Luigi
name: Cavalcanti, Ernesta
name: Sale, Silvia
name: Nicastro, Carmine
name: Atripaldi, Luigi
name: Starita, Noemy
name: Cerasuolo, Andrea
name: Reimer, Ulf
name: Holenya, Pavlo
name: Buonaguro, Luigi
name: Buonaguro, Franco M.
name: Tornesello, Maria Lina
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5: Table S5. Clinical and laboratory parameters of children hospitalized with SARS-CoV-2 infection.
Is the KiRA Device Useful in Quantifying the Pivot Shift in Anterior Cruciate Ligament–Deficient Knees?
Creators: name: RJ Napier
name: Feller, Julian
name: Devitt, Brian Meldan
name: McClelland, Jodie
name: Webster, Kate
name: CSJ Thrush
name: Whitehead, Timothy S.
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © The Author(s) 2021. Background: Various technologies have been developed to quantify the pivot shift, as it is regarded as a key indicator of anterolateral rotatory laxity of the knee. Purpose: To determine the usefulness of a commercially available triaxial accelerometer (Kinematic Rapid Assessment [KiRA]) in numerically quantifying the pivot shift in patients under anesthesia with an anterior cruciate ligament (ACL)–deficient knee. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Both knees of 50 patients (26 male [mean age, 30.4 years], 24 female [mean age, 26.6 years]) under anesthesia were assessed immediately before unilateral ACL reconstruction by an orthopaedic fellow and 1 of 3 experienced knee surgeons. The pivot-shift grade and 2 KiRA outputs (range of acceleration and slope of acceleration change) were compared. Results: The surgeon and fellow recorded the same pivot-shift grade for 45 of 50 patients (90%). Data from the 5 patients with no agreement and 1 patient with extreme outlying data were excluded from subsequent analysis. Using the KiRA range and slope data, the surgeon identified the injured knee in 74% and 76% of patients, respectively, while the fellow’s rate of injured knee identification was 74% and 80%, respectively. A correlation could be found only between pivot-shift grade and surgeon-derived range data (ρ = 0.40; P 5 m/s2) and a grade 1 or 2 pivot (<5 m/s2) (P =.01). Conclusion: Although a correlation between KiRA output data and pivot-shift grade was found when the device was used by an experienced surgeon, there was no correlation when used by a well-trained but less experienced orthopaedic fellow. Furthermore, the KiRA output data identified the ACL-deficient knee correctly in only 74% of patients. Although a threshold acceleration range value could be identified, above which the value was associated with a grade 3 pivot shift, this was dependent on the examiner, and distinction between other grades could not be made.
Persistent identifiers for specimens/samples are way more than yet another label
Creators: name: Wyborn, Lesley
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Persistent identifiers for specimens/samples are way more than yet another label by Lesley Wyborn of Australian National Data Service Acton Australia for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
The chemical composition of the aerial parts essential oils of four Andryala species (Asteraceae) growing wild in Morocco
Creators: name: Badalamenti, Natale
name: Bruno, Maurizio
name: Ilardi, Vincenzo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Andryala (Asteraceae: Cichorieae) is a little-known Mediterranean-Macaronesian genus whose taxonomy is very much in need of revision. In the present study, the chemical composition of the essential oils (EOs) from aerial parts of as many Andryala species, A. integrifolia, A. cossyrensis, and A. rothia, never studied before, and of A. pinnatifida subsp. mogadorensis, all collected in Morocco, was evaluated by GC-MS. The main components of the EOs of A. integrifolia and A. pinnatifida subsp. mogadorensis were organic acid compounds (41.10% and 43.52%, respectively), whereas A. cossyrensis, and A. rothia were shown to be rich in alkane derivatives (43.10% and 34.29%, respectively). Aldehydic compounds were the second class of metabolites in A. integrifolia and A. rothia (26.67% and 21.91%, respectively), whereas terpenoids, represented in all the four species in limited amounts, were more abundant only in A. pinnatifida subsp. mogadorensis (9.90%) and A. rothia (11.79%) species.
Worlds Collide when 3D Printers Reach the Public: Modeling a Digital Gun Control Law After the Digital Millennium Copyright Act
Creators: name: McMullen, Katie Fleschner
Publisher: name: Michigan State University College of Law
Year: 2014
Subjects: subject: Criminal law
subject: Law
subject: FOS: Law

description: Article published in the Michigan State Law Review.
description: Article published in the Michigan State Law Review.
Phage-encoded endolysins
Creators: name: F Abdelrahman
name: M Easwaran
name: OI Daramola
name: S Ragab
name: Lynch, Stephanie
name: TJ Oduselu
name: FM Khan
name: A Ayobami
name: F Adnan
name: E Torrents
name: S Sanmukh
name: A El-Shibiny
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan externally without the assistance of phage. Thus, their incorporation in therapeutic strategies has opened new options for therapeutic application against bacterial infections in the human and veterinary sectors, as well as within the agricultural and biotechnology sectors. While endolysins show promising results within the laboratory, it is important to document their resistance, safety, and immunogenicity for in-vivo application. This review aims to provide new insights into the synergy between endolysins and antibiotics, as well as the formulation of endolysins. Thus, it provides crucial information for clinical trials involving endolysins.
Photonics4All App Flyer
Creators: name: Gerente, Fiona
Publisher: name: Zenodo
Year: 2016
Subjects: Photonics
Light
science communication
learning
discovering
physics students
Teacher
App

description: The Photonics4All-App is one of the tools developed within the Photonics4All outreach program. This flyer informs where it is possible do download the app or use the online version.

The App has mostly been developed to address young people (via their smartphones and tablets). It will also be used for promotion of photonics for the large public (the young people’s parents to start with).

The main objective of the App is to provide basic knowledge on photonics through interractive and fun games/activities included in the App.
Supplemental_Table_1 – Supplemental material for Autistic traits are related to worse performance in a volatile reward learning task despite adaptive learning rates
Creators: name: Goris, Judith
name: Silvetti, Massimo
name: Verguts, Tom
name: Wiersema, Jan R
name: Brass, Marcel
name: Senne Braem
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, Supplemental_Table_1 for Autistic traits are related to worse performance in a volatile reward learning task despite adaptive learning rates by Judith Goris, Massimo Silvetti, Tom Verguts, Jan R Wiersema, Marcel Brass and Senne Braem in Autism
Additional file 2 of Autism-associated gene shank3 is necessary for social contagion in zebrafish
Creators: name: Kareklas, Kyriacos
name: Teles, Magda C.
name: Dreosti, Elena
name: Oliveira, Rui F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Figures showing differences in expression levels between wild-types and mutants for each neuroplasticity marker.
FORMATION OF COMMUNICATIVE COMPETENCIES OF ELEMENTARY SCHOOL STUDENTS IN COOPERATION WITH PARENTS
Creators: name: Kudyarova, Artikgul
Publisher: name: Zenodo
Year: 2024

description: Іn thіs thesіs, the іmportant factors related to speech development, speech competences, іn partіcular, the lіnguіstіc and pedagogіcal features of іmprovіng students' speech competences іn prіmary educatіon mother tongue classes are analyzed.
Perspectives and challenges of creating a new museum in 21st century Brazil
Creators: name: Toscano, Bruna
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Perspectives and challenges of creating a new museum in 21st century Brazil by Bruna Toscano of Museum of Biology Brasilia Brazil for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
A new lanosyl guanidine from Vertebrata lanosa with anti-inflammatory activity
Creators: name: Jacobtorweihen, Joshua
name: Obaidi, Ismael
name: Sherlock, Lee
name: Sheridan, Helen
name: Spiegler, Verena
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: N-Lanosyl guanidine (1), a new bromophenol containing a guanidine moiety was isolated from the red alga Vertebrata lanosa (L.) T.A. Christensen, which is frequently used for cosmetic purposes. Structure elucidation was performed by means of mass spectrometry as well as 1D and 2D NMR spectroscopy. Due to its structural features, 1 might share a common biosynthetic route with known bromophenolic ureido derivatives. Regarding potential bioactivities, 1 has shown clear anti-inflammatory properties, reducing cytokine release in lipopolysaccharide-stimulated phorbol 12-myristate 13-acetate-differentiated THP-1 macrophages. No signs of toxicity were observed, in either the cell line nor in the nematode Caenorhabditis elegans. However, 1 was inactive against the gram-negative bacterium Pseudomonas aeruginosa.
Additional file 5 of Autism-associated gene shank3 is necessary for social contagion in zebrafish
Creators: name: Kareklas, Kyriacos
name: Teles, Magda C.
name: Dreosti, Elena
name: Oliveira, Rui F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5. Primer sequences and parameters used for the qRT-PCR analyses.
Characterisation of cellulose synthase like F6 (CslF6) mutants shows altered carbon metabolism in β-D-(1,3;1,4)-glucan deficient grain in Brachypodium distachyon
Creators: name: Bain, Melissa
name: van de Meene, Allison
name: Costa, Rafael
name: Doblin, Monika
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Brachypodium distachyon is a small, fast growing grass species in the Pooideae subfamily that has become established as a model for other temperate cereals of agricultural significance, such as barley (Hordeum vulgare) and wheat (Triticum aestivum). The unusually high content in whole grains of β-D-(1,3;1,4)-glucan or mixed linkage glucan (MLG), considered a valuable dietary fibre due to its increased solubility in water compared with cellulose, makes B. distachyon an attractive model for these polysaccharides. The carbohydrate composition of grain in B. distachyon is interesting not only in understanding the synthesis of MLG, but more broadly in the mechanism(s) of carbon partitioning in cereal grains. Several mutants in the major MLG synthase, cellulose synthase like (CSL) F6, were identified in a screen of a TILLING population that show a loss of function in vitro. Surprisingly, loss of cslf6 synthase capacity appears to have a severe impact on survival, growth, and development in B. distachyon in contrast to equivalent mutants in barley and rice. One mutant, A656T, which showed milder growth impacts in heterozygotes shows a 21% (w/w) reduction in average grain MLG and more than doubling of starch compared with wildtype. The endosperm architecture of grains with the A656T mutation is altered, with a reduction in wall thickness and increased deposition of starch in larger granules than typical of wildtype B. distachyon. Together these changes demonstrate an alteration in the carbon storage of cslf6 mutant grains in response to reduced MLG synthase capacity and a possible cross-regulation with starch synthesis which should be a focus in future work in composition of these grains. The consequences of these findings for the use of B. distachyon as a model species for understanding MLG synthesis, and more broadly the implications for improving the nutritional value of cereal grains through alteration of soluble dietary fibre content are discussed.