cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Proton occupancies in histidine side chains of carbonic anhydrase II by neutron crystallography and NMR : differences, similarities and opportunities
Creators: name: Fisher, Suzanne Zoë
name: Raum, Heiner N.
name: Weininger, Ulrich
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 530

description: Histidine is a key amino-acid residues in proteins that can exist in three different protonation states: two different neutral tautomeric forms and a protonated, positively charged one. It can act as both donor and acceptor of hydrogen bonds, coordinate metal ions, and engage in acid/base catalysis. Human Carbonic Anhydrase II (HCA II) is a pivotal enzyme catalyzing the reversible hydration of carbon dioxide. It contains 12 histidine residues: six are surface exposed, two buried, three are active site zinc ion ligands, and one is a proton shuttle. Comparing results from NMR spectroscopy with previously determined neutron protein crystal structures enabled a side-by-side investigation of the proton occupancies and preferred tautomeric states of the histidine residues in HCA II. Buried and zinc coordinating histidines remain in one neutral tautomeric state across the entire pH range studied, as validated by both methods. In contrast, solvent-exposed histidines display high variability in proton occupancies. While the data were overall remarkably consistent between methods, some discrepancies were observed, shedding light on the limitations of each technique. Therefore, combining these methods with full awareness of the advantages and drawbacks of each, provides insights into the dynamic protonation landscape of HCA II histidines, crucial for elucidating enzyme catalytic mechanisms.
The impact of humidity on high temperature corrosion of ferritic-austenitic model alloys in the presence of KCL
Creators: name: Kingsbery, Phillip Frederik
name: John, T.
name: Stephan-Scherb, Christiane
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 550

description: This study investigates the impact of humidity on the corrosion behavior of an Fe–18Cr–12Ni alloy in environments containing KCl, as a deposit, and either laboratory air or SO2 at 560°C for exposure times up to 330 h. Corrosion characteristics were analyzed using scanning electron microscopy (SEM) and X‐ray diffraction (XRD) with subsequent Rietveld analysis to quantify the obtained reaction products. Samples exposed to lab air and KCl showed half the weight gain in humid air than in dry atmospheres (0.80 mg ± 0.06 cm mg 2 cm2 at 30.00% ± 0.07% relative humidity (r.H.) vs. 1.63 ± 0.01 mg cm mg 2 cm2 at 1.58% ± 0.09% r.H.). The surface porosity, as determined by image analysis of SEM surface images, was lower for the samples exposed to humid air compared to dry air (5.5% ± 2.1% vs. 11.0% ± 2.2%, respectively). In a SO2 containing environment humidity decreased the scale thickness for deposit induced corrosion significantly by one order of magnitude, reflected by a low amount of oxide phases such as Cr O , Fe O 2 3 2 3 , and Fe3O4. This study shows that humidity present in a hot gas containing other corrosive species, such as SO2, can be beneficial for KCl deposit induced corrosion of stainless steels.
Forested Natura 2000 sites under climate change : effects of tree species distribution shifts
Creators: name: Reichmuth, Anne
name: Kühn, Ingolf
name: Schmidt, Andreas
name: Doktor, Daniel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 580

description: Climate change can have severe impacts on tree species distributions. Models consistently show that tree species will follow climate towards higher elevations and latitudes. This has various effects on forest ecosystems. Forests have a slow dynamic compared to other ecosystems and are affected severely by tree species distribution shifts. Forested conservation areas with limited management reveal a slow adaptation process to a changing climate. In this study, we have modelled and analysed the effect of possible tree species distribution shift in Norway spruce (Picea abies), European beech (Fagus sylvatica), and two oak species (Quercus petraea and Quercus robur), considered jointly on forested Natura 2000 sites, an EU-wide conservation area network. The modelling procedure was performed using 3 to 4 bio-climatic variables derived from 26 variables of the EURO-CORDEX Coupled Model Intercomparison Project Phase 5 (CMIP5) climate simulations for the Representative Concentration Pathways (RCPs) 2.6, 4.5, and 8.5 until 2098. Our results reveal a severe decline in Picea within Natura 2000 sites in central Europe and lower elevations and confirm a strong shift towards higher elevations and latitudes. This amounts to an 18 % absolute mean change (−18 % mean loss, 15 % mean gain). Quercus sp. reveal similar results, with 23 % absolute mean change (−23 % loss, 24 % gain) at Natura 2000 sites, whereas Fagus remains stable throughout the model results with 8 % absolute mean change (−7 % loss, 9 % gain). The best model algorithms for all species were the generalised additive models (GAMs). As ecosystems of any type are highly dynamic, climate change can lead to additional severe pressure on statically defined conservation goals and associated management activities.
Determining dual-task costs and exploring interindividual responsiveness to an opponent using virtual reality
Creators: name: Pastel, Stefan
name: Schwadtke, A.
name: Krahmer, A.
name: Altrogge, Katharina
name: Bürger, D.
name: Heilmann, Florian
name: Witte, K.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Introduction: Dual-task (DT) ability is essential in sports, where athletes must perform motor and cognitive tasks simultaneously. Virtual reality (VR), with its enhanced performance and affordability, offers a valuable tool for training and assessing these abilities. This study aimed to develop VR scenarios to measure DT costs and compare DT ability between athletes from individual (IG) and team (TG) sports using a basketball-specific scenario. Methods: 29 participants completed two experiments to examine DT ability: a reaching and a dribbling task (DR). The reaching involved three tasks: walking a 4-m track, standing while reacting to popping balls, and a combination of both. Parameters such as step length, gait time, and reaction were measured. In DR, participants dribbled while reacting to a virtual opponent. Data on conduction time, errors, reaction time, gaze behavior (GB), and decision-making were analyzed. Results: Significant differences were found between single and DT performances, with DT costs reaching up to 20% (p > 0.05). However, no significant differences were observed between IG and TG for selected parameters (F (1, 28) = 1.104, p = 0.410, partial η2 = 0.380). Discussion: Differences in GB and decision-making were noted and discussed. VR proved effective in assessing DT costs and providing insights into decision-making processes.
Reshaping the path of vascular cognitive impairment with resistance training: a study protocol for a randomized controlled trial
Creators: name: Liu-Ambrose, Teresa
name: Dao, Elizabeth
name: Crockett, Rachel A.
name: Barha, Cindy K.
name: Falck, Ryan S.
name: Best, John R.
name: Hsiung, Ging-Yuek R.
name: Field, Thalia S.
name: Madden, Kenneth M.
name: Alkeridy, Walid A.
name: Boa Sorte Silva, Narlon C.
name: Davis, Jennifer Colleen
name: Ten Brinke, Lisanne F.
name: Doherty, Stephanie
name: Tam, Roger
Publisher: name: BioMed Central
Year: 2021

description: Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Importantly, SIVCI is considered the most treatable form of cognitive impairment in older adults, due to its modifiable risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia. Exercise training is a promising intervention to delay the progression of SIVCI, as it actively targets these cardiometabolic risk factors. Despite the demonstrated benefits of resistance training on cognitive function and emerging evidence suggesting resistance training may reduce the progression of white matter hyperintensities (WMHs), research on SIVCI has predominantly focused on the use of aerobic exercise. Thus, the primary aim of this proof-of-concept randomized controlled trial is to investigate the efficacy of a 12-month, twice-weekly progressive resistance training program on cognitive function and WMH progression in adults with SIVCI. We will also assess the efficiency of the intervention. Methods: Eighty-eight community-dwelling adults, aged > 55 years, with SIVCI from metropolitan Vancouver will be recruited to participate in this study. SIVCI will be determined by the presence of cognitive impairment (Montreal Cognitive Assessment < 26) and cerebral small vessel disease using computed tomography or magnetic resonance imaging. Participants will be randomly allocated to a twice-weekly exercise program of (1) progressive resistance training or (2) balance and tone training (i.e., active control). The primary outcomes are cognitive function measured by the Alzheimer’s Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-13 with additional cognitive tests) and WMH progression. Discussion: The burden of SIVCI is immense, and to our knowledge, this will be the first study to quantify the effect of progressive resistance training on cognitive function and WMH progression among adults with SIVCI. Slowing the rate of cognitive decline and WMH progression could preserve functional independence and quality of life. This could lead to reduced health care costs and avoidance of early institutional care. Trial registration: ClinicalTrials.gov NCT02669394 . Registered on February 1, 2016
Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives.
Creators: name: Jiang, Yunsong
name: Torun, Tugce
name: Maffioletti, Sara M
name: Serio, Andrea
name: Tedesco, Francesco Saverio
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Imaging
subject: Human Biology & Physiology
subject: Microfabrication & Bioengineering
subject: Cell Biology
subject: Stem Cells

description: Engineering models of human skeletal muscle tissue provides unique translational opportunities to investigate and develop therapeutic strategies for acute muscle injuries, and to establish personalised and precision medicine platforms for in vitro studies of severe neuromuscular and musculoskeletal disorders. Several myogenic and non-myogenic cell types can be isolated, generated, amplified and combined with scaffolds and biomaterials to achieve this aim. Novel bio-fabrication strategies, which include exogenous stimuli to enhance tissue maturation, promise to achieve an ever-increasing degree of tissue functionalisation both in vivo and in vitro. Here we review recent advances, current challenges and future perspectives to build human skeletal muscle tissue "in a dish", focusing on the cellular constituents and on applications for in vitro disease modelling. We also briefly discuss the impact that emerging technologies such as 3D bioprinting, organ-on-chip and organoids might have to circumvent current technical hurdles in future studies.
The role of dysfunctional beliefs about sleep in cognitive behaviour therapy for insomnia
Creators: name: Greenwood, Kenneth Mark
Publisher: name: Swinburne
Year: 2024

description: While a good evidence-base exists for the efficacy of cognitive behavioural therapy for insomnia (CBT-I), the most common cognitive intervention involves restructuring dysfunctional beliefs about sleep which are thought to be important in the aetiology and/or maintenance of insomnia. A literature review revealed that the importance of this component of CBT-I had not been investigated directly and the evidence was not consistent and only provided weak evidence for such cognitive restructuring. The review also exposed flaws in the instrument used to assess such cognitions, the Dysfunctional Beliefs about Sleep Scale (DBAS: Morin, 1993, 1994) and its variants. The psychometric properties of the DBAS and three variants (DBAS-10, DBAS-SF, DBAS-16) and the relationship between DBAS scores and sleep were assessed in community (n = 224) and treatment-seeking insomniac (n = 180) sample. The psychometric properties of all versions of the DBAS were not optimal and only weak relationships were found between DBAS scores and sleep measures. DBAS scores of good and poor sleepers were found to differ with large effect size. While DBAS scores decreased in a sample of people with insomnia (n = 185) over the course of CBT-I, the relationships between changes in DBAS scores and improvements in sleep were not strong. Using the combined evidence, it was concluded that there was no advantage of any of the versions of the DBAS over the original scale and that theme 2 scores of the DBAS-ii were the best measure of dysfunctional beliefs about sleep. It was also concluded that there was only weak evidence for such beliefs being involved in the aetiology and/or maintenance of insomnia, and that a more parsimonious explanation of the results was that these beliefs were a consequence of poor sleep. Better evidence is required about the importance of modifying dysfunctional cognitions about sleep in CBT for insomnia (CBT-I). It is possible that the inclusion of this component is unimportant and distracts the therapists' and clients' attention away from components which are more central to the efficacy of the approach. Ultimately, studies are required which directly compare outcomes using a CBT package including cognitive restructuring and the same package with the cognitive restructuring omitted or which compare a package involving cognitive restructuring alone with a suitable comparison group. However, these studies need a better measure of dysfunctional beliefs about sleep. Suggestions for improvements in the measure and for future research were made.
Core-shell microgels at air/water interfaces : role of interfacial tension in monolayer evolution
Creators: name: Zhou, Yichu
name: Crassous, Jérôme
name: Karg, Matthias
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 540

description: Core–shell microgels with rigid cores and soft, deformable hydrogel shells can assemble at air–water interfaces, forming freely floating monolayers. The strong adsorption at such interfaces is related to the reduction in interfacial tension, which also causes the microgels to deform laterally. The degree of this deformation is typically controlled through applied surface pressure. Until now, surprisingly little has been known about the impact of interfacial tension imbalances between interfacial areas covered with a microgel monolayer and microgel-free areas in the surroundings. In this work, we systematically study the monolayer evolution at air/water interfaces in dependence of interfacial tension controlled by the addition of sodium dodecyl sulfate or linear poly-N-isopropylacrylamide homopolymer to the free area. We do this by globally monitoring the evolution of the area of freely floating monolayers. Macroscopic changes are also related to the local microstructure studied by atomic force microscopy (AFM). Depending on the interfacial tension imbalance, the monolayer either expands, shrinks, or maintains its conformation. The kinetics of monolayer expansion is compared for core–shell microgels with the same silica core and varying cross-linker densities. Our study reveals the impact of interfacial tension on the behavior of microgel monolayers at liquid interfaces and also provides useful insights into controlling the two-dimensional (2D) microstructure without the need for a Langmuir trough.
Präventiver Nutzen von Schulsozialarbeit im Kontext von Cyber-Grooming
Creators: name: Lieske, Emily Sarah
Publisher: name: Hochschulbibliothek, Hochschule Merseburg
Year: 2023
Subjects: subject: Cyber-Grooming
subject: Schulsozialarbeit
subject: sexueller Missbrauch
subject: DDC::3** Sozialwissenschaften::30* Sozialwissenschaften, Soziologie::302 Soziale Interaktion

description: Das Ziel der Arbeit ist es herauszufinden, welche Möglichkeiten die Schulsozialarbeit bei der Prävention von Cyber-Grooming, also der Online-Anbahnung eines sexuellen Missbrauchs, hat. ...
Nuclear magnetic resonance- and electron paramagnetic resonance spectroscopic characterization of S4N4 and (SN)x dissolved in [EMIm][OAc]
Creators: name: Radicke, Julian
name: Jerschabek, Vanessa
name: Hashemi Haeri, Haleh
name: Abu Bakar, Muhammad
name: Hinderberger, Dariush
name: Kressler, Jörg
name: Busse, Karsten
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 540

description: This work focuses on the reaction mechanism of poly(sulfur nitride) ((SN)x, (S15N)x), with the ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate [EMIm][OAc]. We compare this with the reaction of the IL with S4N4 or its 15N-labeled form S415N4, a precursor for the synthesis of (SN)x and (S15N)x. After purification of the S4N4–IL- and S415N4–IL systems via column chromatography, we characterized the reaction products with 1H, 13C, and 15N nuclear magnetic resonance spectroscopy and with electron spray ionization time-of-flight mass spectrometry. Furthermore, time-resolved electron paramagnetic resonance spectroscopy and time-resolved ultraviolet–visible spectroscopy were carried out. Thus, radical intermediates were detected, which were consumed with reaction time. Finally, we postulate a reaction mechanism for the S4N4–IL- and S415N4–IL systems and compare this with the respective data for the (SN)x −IL- and (S15N)x–IL-systems.
Policy program evaluation and recommendation
Creators: name: Reiter, Ulrich
name: Lienhard, Larissa
name: Weinberg, Lia
Publisher: name: Zenodo
Year: 2022

description: This report aims at providing an overview on current policy programs on European as well as country
 level, focusing on energy efficiency (EE) policies for the building sector. In the focus are policies which
 are addressing barriers, hindering more investments in EE in the built environment e.g., by addressing
 and increasing the refurbishment rate and the refurbishment depth, amongst others. These two
 parameters are known to be the most relevant factors limiting the achievement of needed energy
 demand reductions to support the decarbonization of the European building stock.
Das Neutralitätsgebot an Hochschulen
Creators: name: Rakutt, Moritz
Publisher: name: Hochschulbibliothek, Hochschule Merseburg
Year: 2021
Subjects: subject: politische Neutralität
subject: Neutralität an Hochschulen
subject: Neutralitätsgebot
subject: Beutelsbacher Konsens
subject: DDC::3** Sozialwissenschaften::32* Politikwissenschaft

description: Die vorliegende Arbeit untersucht die Bedeutung des Neutralitätsgebot für den politischen Diskurs an Hochschulen in der Bundesrepublik Deutschland. Es soll betrachtet werden, wie Sprache in politischen Auseinandersetzungen an Hochschulen benutzt wird und welche Vorstellungen mit einzelnen Begriffen wie „Neutralität“ oder „Neutralitätsgebot“ verbunden sind. Zur Untersuchung dieser Frage wird wissenschaftliche Literatur herangezogen.
A simple in vitro method to determine bactericidal activity against Mycobacterium abscessus under hypoxic conditions
Creators: name: Feilcke, Ruth
name: Eckenstaler, Robert
name: Lang, Markus
name: Richter, Adrian
name: Imming, Peter
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 615

description: Background/Objectives: Non-replicating persisters (NRPs) of Mycobacterium abscessus are a bacterial subpopulation that can survive in the host under unfavorable conditions, such as hypoxia or nutrient starvation. The eradication of these bacteria is difficult, which is one reason for the long treatment duration and treatment failure. The drug discovery process should therefore contain methods to screen activity against NRPs. Methods: A hypoxic environment is used to generate NRPs of M. abscessus that are termed low-oxygen persisters (LOPs). For this, an oxidation process is used to transition a replicating culture of M. abscessus distributed in microtiter plates within a sealable box into LOPs. Colony counting, automated object counting, bactericidal activity determination of known agents, and confocal laser scanning microscopy are used to study the obtained culture. Results: The obtained culture shows typical attributes of non-replicating cells, such as significantly reduced replication, the reversibility of the LOP state under aerobic conditions, delayed regrowth on solid medium, altered morphological patterns on a single-cell level, and phenotypical resistance against a variety of clinically relevant antimycobacterial compounds. The study reveals metronidazole and niclosamide as bactericidal against M. abscessus LOPs. These compounds can be used as LOP verification compounds within the described model. Conclusions: Our model is easily implemented and quickly identifies compounds that are inactive under hypoxic conditions. It can therefore accelerate the identification of clinically effective antimycobacterial drug substances, and can be a helpful tool during the drug development process.
Nanopore-Level Wood-Water Interactions—A Molecular Simulation Study
Creators: name: Shi, Jingbo
name: Avramidis, Stavros
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: The nanoscale wood-water interaction strength, accessible sorption sites, and cell wall pore sizes are important factors that drive water sorption and the hysteresis phenomenon in wood. In this work, these factors were quantitatively studied using molecular simulations based on a cell wall pore model, previously developed by the authors. Specifically, the wall-water interaction strength, the sorption sites network including their number, interaction range, strength, and spatial distributions were set at a series of theoretical values as simulation input parameters. The results revealed that most of the investigated parameters significantly affected both sorption isotherms and hysteresis. Water monolayers and clusters were observed on the simulated pore surface when the wood-water interaction and sorption site strength were set at unrealistically high values. Furthermore, multiple linear regression models suggested that wood-water interaction and sorption site parameters were coupled in determining sorption isotherms, but not in determining hysteresis.
Synthématique nominale : documents d'époque en alsacien de Mulhouse
Creators: name: Vogler Pierre
Publisher: name: Zenodo
Year: 2022
Subjects: german dialectology

description: La synthématique regroupe les procédés de composition et de dérivation, ici propres à l'alsacien de Mulhouse. Ils se distinguent radicalement de ceux de la syntagmatique en considération de l'impossibilité d'affecter des déterminations spécifiques aux composants en cause : le comportement des synthèmes est identique à celui des monèmes uniques. D'autre part, la synthématique fournit des unités qui font partie du 'trésor' de la langue, mais qui peuvent également se constituer de manière libre, tout en étant immédiatement comprises comme telles par l'auditeur.
Antifouling and Flux Enhancement of Reverse Osmosis Membrane by Grafting Poly (3-Sulfopropyl Methacrylate) Brushes
Creators: name: Mushtaq, Reema
name: Abbas, Muhammad Asad
name: Mushtaq, Shehla
name: Ahmad, Nasir M.
name: Khan, Niaz Ali
name: Khan, Asad U.
name: Hong, Wu
name: Sadiq, Rehan
name: Jiang, Zhongyi
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: A commercial thin film composite (TFC) polyamide (PA) reverse osmosis membrane was grafted with 3-sulfopropyl methacrylate potassium (SPMK) to produce PA-g-SPMK by atom transfer radical polymerization (ATRP). The grafting of PA was done at varied concentrations of SPMK, and its effect on the surface composition and morphology was studied by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), optical profilometry, and contact angle analysis. The grafting of hydrophilic ionically charged PSPMK polymer brushes having acrylate and sulfonate groups resulted in enhanced hydrophilicity rendering a reduction of contact angle from 58° of pristine membrane sample labeled as MH0 to 10° for a modified membrane sample labeled as MH3. Due to the increased hydrophilicity, the flux rate rises from 57.1 L m⁻² h⁻¹ to 71.2 L m⁻² h⁻¹, and 99% resistance against microbial adhesion (Escherichia coli and Staphylococcus aureus) was obtained for MH3 after modification.
Probabilistic model-checking support for FMEA
Creators: name: Grunske, Lars
name: Colvin, Robert
name: Winter, Kirsten
Publisher: name: Swinburne
Year: 2024

description: Failure Mode and Effect Analysis (FMEA) is a method for assessing cause-consequence relations between component faults and hazards that may occur during the lifetime of a system. The analysis is typically time intensive and informal, and for this reason FMEA has been extended with traditional model checking support. Such support does not take into account the probabilities associated with a component fault occurring, yet such information is crucial to developing hazard reduction strategies for a system. In this paper we propose a method for FMEA which makes use of probabilistic fault injection and probabilistic model checking. Based on this approach safety engineers are able to formally identify if a failure mode occurs with a probability higher than its tolerable hazard rate.
The influence of the development of reference interest rates in choosing investment and debt financial tools for corporations: case of the Czech Republic in 1997-2002
Creators: name: Polak, Petr
name: Kocurek, Kamil
Publisher: name: Swinburne
Year: 2024

description: This paper focuses on the development of reference interest rates in the Czech Republic after the currency crisis of May 1997 and covers the period to the years 2002/2003 (that is to the time just before the country’s entry into the European Union in May 2004) when the currency exchange of the Czech koruna (CZK) and interest rates were stabilised. The relatively high volatility of Czech reference interest rates in the late 1990’s influenced the development of company debt financing, forcing companies to become more sophisticated and dynamic in their use of debt instruments and hedging tools as they attempt to manage the subsequent interest rate risk. In this paper, the situation in three model corporations is also described – the first, a solvent company with a foreign owner (Moravian-Silesian Heating Company – MSHC, renamed to Dalkia Morava in 2002), the second, a solvent company with the Czech state as its majority owner (North Moravian Power Company – NMPC), and the third with domestic capital, which had economic problems during the given period (Vítkovice, a.s.), plus a big insurance company as a specific and very important institutional investor in a domestic financial markets.
Lifecycle Management of Optical Networks with Dynamic-Updating Digital Twin: A Hybrid Data-Driven and Physics-Informed Approach
Creators: name: Song, Yuchen
name: Zhang, Min
name: Zhang, Yao
name: Shi, Yan
name: Shen, Shikui
name: Tang, Xiongyan
name: Huang, Shanguo
name: Wang, Danshi
Publisher: name: arXiv
Year: 2025
Subjects: subject: Optics (physics.optics)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Digital twin (DT) techniques have been proposed for the autonomous operation and lifecycle management of next-generation optical networks. To fully utilize potential capacity and accommodate dynamic services, the DT must dynamically update in sync with deployed optical networks throughout their lifecycle, ensuring low-margin operation. This paper proposes a dynamic-updating DT for the lifecycle management of optical networks, employing a hybrid approach that integrates data-driven and physics-informed techniques for fiber channel modeling. This integration ensures both rapid calculation speed and high physics consistency in optical performance prediction while enabling the dynamic updating of critical physical parameters for DT. The lifecycle management of optical networks, covering accurate performance prediction at the network deployment and dynamic updating during network operation, is demonstrated through simulation in a large-scale network. Up to 100 times speedup in prediction is observed compared to classical numerical methods. In addition, the fiber Raman gain strength, amplifier frequency-dependent gain profile, and connector loss between fiber and amplifier on C and L bands can be simultaneously updated. Moreover, the dynamic-updating DT is verified on a field-trial C+L-band transmission link, achieving a maximum accuracy improvement of 1.4 dB for performance estimation post-device replacement. Overall, the dynamic-updating DT holds promise for driving the next-generation optical networks towards lifecycle autonomous management.
description: This article has been accepted for publication in IEEE Journal on Selected Areas in Communications
title: Perceptions of Quality in Higher Education in Afghanistan: A Case Study of Shaheed Rabbani Education University
Creators: name: Taheryar, Homayoon
Publisher: name: University of Massachusetts Amherst
Year: 2017
Subjects: subject: quality
subject: quality assurance
subject: enhancement
subject: improvement
subject: quality standards
subject: higher education
subject: Afghanistan
subject: Shaheed Rabbani Education University
subject: SREU
subject: Education
subject: International and Comparative Education

description: This study investigates how the concepts of quality and quality assurance (QA) standards are understood in the Afghan higher education system. First, I carried out a literature review of the available literature globally and then reviewed the available literature about Afghanistan’s higher education quality assurance system. Second, I conducted a case study at Shaheed Rabbani Education University (SREU), a public higher education institution in Afghanistan, to explore how academic staff at this university understand the concepts of quality and the QA standards. The study included qualitative interviews with seven key respondents at SREU. The findings from the case study suggest academic staff at SREU perceive quality and the fulfillment of QA standards mainly as the need for more inputs and resources such as more classrooms equipped with modern technology, better libraries, and more qualified faculty with Master’s and PhD degrees. In addition, the findings suggest that QA standards and practices at SREU need to be clarified further and should be revised to better match the available resources allocated to it and other public higher education institutions by the government. SREU needs to operationalize quality improvement practices in their daily activities by focusing more on student learning outcomes and improvement in administration using currently available resources.
How much leeway is there to relax COVID-19 control measures?
Creators: name: Anderson, Sean C.
name: Mulberry, Nicola
name: Edwards, Andrew M.
name: Stockdale, Jessica E.
name: Iyaniwura, Sarafa
name: Falcao, Rebeca Cardim
name: Otterstatter, Michael
name: Janjua, Naveed Z.
name: Coombs, Daniel
name: Colijn, Caroline
Publisher: name: Elsevier
Year: 2021

description: Following successful non-pharmaceutical interventions (NPI) aiming to control COVID-19, many jurisdictions reopened their economies and borders. As little immunity had developed in most populations, re-establishing higher contact carried substantial risks, and therefore many locations began to see resurgence in COVID19 cases. We present a Bayesian method to estimate the leeway to reopen, or alternatively the strength of change required to re-establish COVID-19 control, in a range of jurisdictions experiencing different COVID-19 epidemics. We estimated the timing and strength of initial control measures such as widespread distancing and compared the leeway jurisdictions had to reopen immediately after NPI measures to later estimates of leeway. Finally, we quantified risks associated with reopening and the likely burden of new cases due to introductions from other jurisdictions. We found widely varying leeway to reopen. After initial NPI measures took effect, some jurisdictions had substantial leeway (e.g., Japan, New Zealand, Germany) with > 0.99 probability that contact rates were below 80% of the threshold for epidemic growth. Others had little leeway (e.g., the United Kingdom, Washington State) and some had none (e.g., Sweden, California). For most such regions, increases in contact rate of 1.5–2 fold would have had high (> 0.7) probability of exceeding past peak sizes. Most jurisdictions experienced June–August trajectories consistent with our projections of contact rate increases of 1–2-fold. Under such relaxation scenarios for some regions, we projected up to ∼100 additional cases if just one case were imported per week over six weeks, even between jurisdictions with comparable COVID-19 risk. We provide an R package covidseir to enable jurisdictions to estimate leeway and forecast cases under different future contact patterns. Estimates of leeway can establish a quantitative basis for decisions about reopening. We recommend a cautious approach to reopening economies and borders, coupled with strong monitoring for changes in transmission.
title: Monitoring Endothelin-A Receptor Expression during the Progression of Atherosclerosis
Creators: name: Stölting, Miriam
name: Geyer, Christiane
name: Helfen, Anne
name: Hahnenkamp, Anke
name: Usai, Marco V.
name: Wardelmann, Eva
name: Kuhlmann, Michael Theodor
name: Wildgruber, Moritz
name: Höltke, Carsten
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 610 Medicine and health

description: Cardiovascular disease remains the most frequent cause of death worldwide. Atherosclerosis, an underlying cause of cardiovascular disease, is an inflammatory disorder associated with endothelial dysfunction. The endothelin system plays a crucial role in the pathogenesis of endothelial dysfunction and is involved in the development of atherosclerosis. We aimed to reveal the expression levels of the endothelin-A receptor (ETAR) in the course of atherogenesis to reveal possible time frames for targeted imaging and interventions. We used the ApoE−/− mice model and human specimens and evaluated ETAR expression by quantitative rtPCR (qPCR), histology and fluorescence molecular imaging. We found a significant upregulation of ETAR after 22 weeks of high-fat diet in the aortae of ApoE−/− mice. With regard to translation to human disease, we applied the fluorescent probe to fresh explants of human carotid and femoral artery specimens. The findings were correlated with qPCR and histology. While ETAR is upregulated during the progression of early atherosclerosis in the ApoE−/− mouse model, we found that ETAR expression is substantially reduced in advanced human atherosclerotic plaques. Moreover, those expression changes were clearly depicted by fluorescence imaging using our in-house designed ETAR-Cy 5.5 probe confirming its specificity and potential use in future studies.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
HUMAN RESOURCE ACCOUNTING AND QUALITY OF EARNINGS IN LISTED OIL AND GAS COMPANIES IN NIGERIA
Creators: name: Ojediran, Sunday
name: Akinlade, Olayinka Odunayo (P.hD)*
name: Hassan, Kolawole Abdullahi (P.hD)
name: Adedokun, Lateef Babatunde
Publisher: name: Zenodo
Year: 2024
Subjects: Earnings Quality, Financial Reporting, Human Resource Accounting, Oil and Gas Sector, Regulatory Compliance.

description: Abstract: Earnings quality indicates an organization’s capacity to produce sustainable and predictable future earnings based on its reported net income or profit. Evaluating earnings quality necessitates a comprehensive examination of a company’s financial documents and tax records, typically conducted by financial analysts or consulting firms. The preparation and presentation of performance reports are crucial, as they significantly affect stakeholder perceptions. Hence, the quality of earnings and the way it is reported play a vital role in shaping the public image of the entity. This research explores the relationship between human resource accounting and earnings quality within the oil and gas sector listed in Nigeria, focusing on variables such as operating cycle, sales volatility, performance, and liquidity. Using both survey and ex-post facto designs. The study encompasses a sample of 9 oil and gas firms from a population of 12 over a 15-year span (2008–2023). The research involved collecting data from 200 observations from these companies, which were analyzed using valid diagnostic tests, pooled OLS, and multiple regression analysis to investigate the relationships between variables. The main findings reveal that human resource accounting has a significant effect on earnings quality in Nigeria's listed oil and gas sector, as indicated by F(4,133) = 69.43, p-value = 0.000, adjusted R2 = 0.515, and R2 = 0.546, resulting in the rejection of the null hypotheses (H0). Consequently, the study concludes that human resource accounting positively influences earnings quality in these firms. Recommendations include urging regulatory bodies to create incentives for adherence to earnings quality standards, enhance transparency in disclosures, and penalize companies that withhold essential information. Additionally, firms should refrain from manipulating earnings to disguise inefficiencies, as this behavior adversely affects earnings quality.
title: Fridericus Wilh. Pestel I.U.D. eiusque et philosophiae moralis in Ernestina p.p. ordinis ... et philosophorum h.t. decanus examen publicum viri praenobilissimi Ludov. Godofredi Henkel Hassi a.d. X. Maii MDCCLII. h.l.q.c. indicit
Creators: name: Pestel, Friedrich Wilhelm
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Universitätsprogramm
Hochschulschrift
Generalities, Science
Allgemeines, Wissenschaft

description: Elektronische Reproduktion von: Fridericvs Wilh. Pestel I.V.D. Eivsqve Et Philosophiae Moralis In Ernestina P.P. Ordinis Ivrisconsvltorvm Et Philosophorvm H.T. Decanvs Examen Pvblicvm Viri Praenobilissimi Lvdov. Godofredi Henkel Hassi A.D. X. Maii MDCCLII. H.L.Q.C. Indicit. 
 Praemissa Est De Domicilio Originis : Ad L. Pen. D. De Senator. Dispvtatio. - Rintelii : Typis Ioh. Godof. Enax A.T., [1752]. - 12 ungezählte Seiten ; 4°. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 9. - 
Werktitel: Fridericus Wilh. Pestel I.U.D. eiusque et philosophiae moralis in Ernestina p.p. ordinis ... et philosophorum h.t. decanus examen publicum viri praenobilissimi Ludov. Godofredi Henkel Hassi a.d. X. Maii MDCCLII. h.l.q.c. indicit. - 
Werktitel der Teile/ De Domicilio Originis. - 
Anmerkung: Enthält Lebenslauf des Kandidaten. - 
Gelegenheitsschrift: Einladungsschrift. - 
Erscheinungsjahr nach der Datierung im Haupttitel angenommen; dort in neulateinischen Zahlzeichen mit gespiegeltem "c" dargestellt. - 
Bibliographischer Nachweis: Verzeichnis der im deutschen Sprachbereich erschienenen Drucke des 18. Jahrhunderts, 10301569. - 
(Hassiaca)

Digitalisiert 2024
title: Lobschallendes Glückwünschungs-Gedichte/ Womit Dem ... Hn. Heiderich Hennemann/ ... Wie auch Der ... Jungfrau Dorothea Sophia, Des ... Herrn Theophili Nicolai, ... Tochter ... glücklich geschehener Trauung ...
Creators: name: Anonym
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Festschrift
Manuscripts & rare books
Handschriften, seltene Bücher

description: Elektronische Reproduktion von: Lobschallendes Glückwünschungs-Gedichte/ Womit Dem ... Hn. Heiderich Hennemann/ Der ... Reichs-Stadt Wetzlar ... Pastori ... Wie auch Der ... Jungfrau Dorothea Sophia, Des ... Herrn Theophili Nicolai, ... Tochter Bey derer zu Marburg den 20. Tag Octobris 1697. glücklich geschehener Trauung ... auffwarten und beEhren wollen Ein die Freyen-Künste Proseqirendes/ absonderlich der H. Schrifft beflissenes Gemüht. - Marburg : druckts Joh. Henrich Stock/ Fürstl. Hess. Cantzley Buchdr., [1697]. - 4 ungezählte Seiten ; 4°. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 9. - 
Bemerkungen: Umlaute überwiegend mit übergestelltem "e" dargestellt . - 
(Hassiaca)

Digitalisiert 2024
title: Nuptiis Auspicatissimis Reverendi Et Doctissimi Viri, Dn. M. Davidis Breulæi Marpurgensis Hassi, ...
Creators: name: Wundergast, Johann
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Festschrift
Manuscripts & rare books
Handschriften, seltene Bücher

description: Elektronische Reproduktion von: Nuptiis Auspicatissimis Reverendi Et Doctissimi Viri, Dn. M. Davidis Breulæi Marpurgensis Hassi, Pastoris Obersteinensis Vigilantissimi Cum Pvdicissima Virgine Sabina Reverendi Et Clasissimi Viri Dn. Johannis Fabri [Schmidii] Quondam In Ecclesia Cathedrali Marpurgensi Archidiaconi, Et Ad. D. Elisabetham ... Filia, Sponsa / Gratvlantvr Professores Academiæ Giessenæ, et amici. - Gissæ Hassorum : Excudebat Nicolaus Hampelius, Typogr. Academ., MDCIX. - 8 ungezählte Seiten ; 4°. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 2. - 
 
(Hassiaca)

Digitalisiert 2024
title: Splendore Generis, Et Virtute Praestantissimo Viro
Creators: name: Treutler, Hieronymus
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Einblattdruck
Manuscripts & rare books
Handschriften, seltene Bücher
Festschrift

description: Elektronische Reproduktion von: Splendore Generis, Et Virtute Praestantissimo Viro : Dn. Joanni Friderico Bromm, Patritio Francofortensi; Sponso: Et Lectissimae Virgini Elisabethae: Amplissimi Et Consultissimi viri, D. Hermanni Lersneri, ... Marpurgensium Academiæ Cancellarii, ... Professoris dignissimi, Filiae Sponae, Læti ominis et observantiæ ergò gratulatur / M. Hieronymvs Trevtlervs Silesivs. - Marpurgi : typis Pauli Egenolphi, [1588]. - 1 Bogen. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 2. - 
Bemerkungen: Text teilw. griechisch, in griechischer Schrift. - 
Hochzeitsgedicht . - 
(Hassiaca)

Digitalisiert 2024
title: Mvnvs Thalassionis Nvptiis Nobilitate
title: Munus Thalassionis Nuptiis Nobilitate
titleType: AlternativeTitle
Creators: name: Anonym
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Festschrift
Manuscripts & rare books
Handschriften, seltene Bücher
Einblattdruck

description: Elektronische Reproduktion von: Mvnvs Thalassionis Nvptiis Nobilitate : Præstantis Viri, D. Ioannis Friderci Bromii, Nobilis D. Ieremiae Bromii, Patritii Qvondam Francofvrtensis, Relicti Filii; Sponsi: Et Castissimæ ... Elisabethae: Ampliss. Et Clariss. Viri Hermanni Lerssneri, ... Martisbvrgensis Professoris et ...Filiæ Sponsæ,Cognationis Et Amicitiæ Ergò Oblatvm / Avtore Lectori ... - Francofurdi ad Mœnum : excudebatur typis Spiessianis, Anno, vt in versu, [1588]. - 1 Bogen. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 2. - 
Werktitel: Munus Thalassionis Nuptiis Nobilitate. - 
Anmerkung: Hochzeitsgedicht. - 
Erscheinungsjahr nach einem Chronogramm: Sena bIs Eoo faX FebrVa ab aXe CorVsCans, FœDere ConstrIngIt peCtora CLara DVo. . - 
(Hassiaca)

Digitalisiert 2024
title: Vota Precesq[ue] Pie Conceptae in Sacro Nuptiali
Creators: name: Ferinarius, Johannes
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Einblattdruck
Festschrift
Manuscripts & rare books
Handschriften, seltene Bücher

description: Elektronische Reproduktion von: Vota Precesq[ue] Pie Conceptae in Sacro Nuptiali : Praestantissimi Juvenis Johannis Friderici Bromm, Patritii Francofortensis: Et Lectiss. Pvellæ Elisabethae, Filiae Ampliss. Viri Doctoris Hermanni Lersneri, Academiæ Marpurgensis Vicecancellarij ... / a Iohanne Ferinario Professore. - Marpurgi : typis Pauli Egenolphi, [1588]. - 1 Bogen. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 2. - 
Werktitel: Vota precesque pie conceptae in sacro nuptiali. - 
Anmerkung: Hochzeitsgedicht . - 
(Hassiaca)

Digitalisiert 2024
title: Anverwante Thränen, über den frühzeitigen, jedoch sanfftseeligen Todt des sich gar wohlangelassenen Jünglings Johan-Conrad Brunsteins ...
Creators: name: Anonym
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Nachruf
Christian theology
Theologie, Christentum

description: Elektronische Reproduktion von: Anverwante Thränen, über den frühzeitigen, jedoch sanfftseeligen Todt des sich gar wohlangelassenen Jünglings Johan-Conrad Brunsteins, Herrn Johan-Erici Brunsteins, Mitpredigers zu Cassel annoch eintzigen Söhnleins,alß derselbe nach einer ... den 12. Tag Januarii Anno 1687. im Herrn entschlafen, sehnlich vergossen / von Zween Hertzlichen Freunden. - Cassel : Gedruckt bey Salomon Kürßner, Fürstl. Hess. Buchdr., Jm Jahr Christi 1687. - 7 ungezählte Seiten ; 4°. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 2. - 
Bemerkungen: Umlaute im Text mit übergestelltem e dargestellt . - 

Digitalisiert 2024
title: رحلات القنص في الإمارات: ذِكريات وأحداث/ عائشة الفلاسي.
Creators: name: الفلاسي، عائشة
Publisher: name: الأرشيف والمكتبة الوطنية
Year: 2023
Subjects: الصيد بالصقور - الإمارات العربية المتحدة - تاريخ
الصيد بالصقور - العادات والتقاليد - العالم العربي
الصيد بالصقور - العالم العربي - وصف ورحلات

يعدّ القنص -الصيد بالصقور- تراثًا ثقافيًا توارثته الأجيال عبر العصور والحضارات التاريخية، واتسع وتطور في شبه الجزيرة العربية؛ فقد اعتبر العرب القنص من الممارسات الأصيلة التي يمارسونها في فصول معينة من السنة؛ وما زالوا في الخليج العربي يحافظون على هذا الإرث بممارسته والاحتفاء به ولا سيما في المناطق الداخلية من المملكة العربية السعودية، وتمتد من دولة الإمارت العربية المتحدة جنوبي الخليج باتجاه الشمال مرورًا بقطر والبحرين، ووصولًا إلى الكويت. في هذا المبحث اعتمدت الباحثة في توثيق القنص ورحلاته على عدد من المصادر والمراجع إضافة إلى تجارب الذين قاموا بتلك الرحلات، وعاشوا تفاصيلها، واكتسبوا خبرة منها تستحق التوثيق والتدوين؛ لتسجيل تفاصيل تلك الرحلات التي تعدّ مرجعًا علمّيًا وتاريخيًا للحفاظ على هذا الموروث والاستمرار في إحيائه لنقله إلى الأجيال القادمة.
title: Junge Leichzipressen auf das ungewünschte Grab des frühseelig-verstorbnen Jünglings Johan-Conrad Brunsteins ...
Creators: name: Anonym
Publisher: name: Philipps-Universität Marburg
Year: 2024
Subjects: Manuscripts & rare books
Handschriften, seltene Bücher
Nachruf

description: Elektronische Reproduktion von: Junge Leichzipressen auf das ungewünschte Grab des frühseelig-verstorbnen Jünglings Johan-Conrad Brunsteins, sonderlich wohlgearteten Schülers unsers Pædagogeo minoris, des ... Herrn Johan-Erich Brunsteins, ... Einzig geliebten Söhnleins, Welcher den 25. Octob. Anno 1676 in diese Welt gebohren, und auf eine kurtze krankheit und sanftseelige Entbindung, den 18. Jan. ... 1687. HeilJahrs, Jm Elften aber seines alters, Christliche beschikket ward ... zur Ehre, gepflantzet von einem seiner Lehrvorgesetzten. - Cassel : Gedrukt bei Salomon Kürßner Fürstl. Hess. Buchdr., Jm Jahr Christi 1687. - 4 ungezählte Seiten ; 4°. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 2. - 
Bemerkungen: Umlaute im Text mit übergestelltem e dargestellt. - 
(Hassiaca)

Digitalisiert 2024
Correspondence, Mallie Rybb and T. Bayles Minuse, August 1956
Creators: name: Rybb, Mallie
name: Minuse, Bayles T.
Publisher: name: Unknown
Year: 1956
Subjects: Stony Brook
Correspondence

description: These letters are between T. Bayles Minuse of the Stony Brook Community Fund and Mrs. Mallie Rybb in August 1956, in regards to the death of Mallie's husband, Daniel Rybb.