cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Practical Clinical Approaches to the Problem Breeder Female
Creators: name: Stroud, Brad
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Applied reproductive biotechnology, information technology, and efficient production management systems on the farm have all contributed to an increased awareness and knowledge of reproductive problems. Reproductive history is now documented and we know more than ever about individual females and their problems. Artificial Insemination (AI), emliryo transfer, in vitro fertilization (IVF), real time ultrasound, sex-sorted sperm (Sexing Technologies, Navasota, TX 77868}, and novel heat detection systems (HeatWatch®, Denver, CO 80216) are some of the tools that cattle breeders and veterinarians use to diagnose and treat problem females. Although a small percentage of infertility cases can be diagnosed and treated successfully, the majority of infertility cases in beef cattle are idiopathic in nature. Over half of the infertile females brought to my facility fall into this classification after both palpation and ultrasound examinations. In spite of all the technology available, amazingly little is known about the etiology or pathobiology of the most common form of infertility in cattle. This paper explores possible causes of idiopathic infertility and suggest a systematic method of handling bovine female infertility in a clinical setting.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis.
Creators: name: Smethurst, Phillip
name: Risse, Emmanuel
name: Tyzack, Giulia E
name: Mitchell, Jamie S
name: Doaa M Taha
name: Yun-Ru Chen
name: Newcombe, Jia
name: Collinge, John
name: Sidle, Katie
name: Patani, Rickie
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Stem Cells
subject: Cell Biology

description: Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease caused by motor neuron loss, resulting in muscle wasting, paralysis and eventual death. A key pathological feature of ALS is cytoplasmically mislocalized and aggregated TDP-43 protein in >95% of cases, which is considered to have prion-like properties. Historical studies have predominantly focused on genetic forms of ALS, which represent ∼10% of cases, leaving the remaining 90% of sporadic ALS relatively understudied. Additionally, the role of astrocytes in ALS and their relationship with TDP-43 pathology is also not currently well understood. We have therefore used highly enriched human induced pluripotent stem cell (iPSC)-derived motor neurons and astrocytes to model early cell type-specific features of sporadic ALS. We first demonstrate seeded aggregation of TDP-43 by exposing human iPSC-derived motor neurons to serially passaged sporadic ALS post-mortem tissue (spALS) extracts. Next, we show that human iPSC-derived motor neurons are more vulnerable to TDP-43 aggregation and toxicity compared with their astrocyte counterparts. We demonstrate that these TDP-43 aggregates can more readily propagate from motor neurons into astrocytes in co-culture paradigms. We next found that astrocytes are neuroprotective to seeded aggregation within motor neurons by reducing (mislocalized) cytoplasmic TDP-43, TDP-43 aggregation and cell toxicity. Furthermore, we detected TDP-43 oligomers in these spALS spinal cord extracts, and as such demonstrated that highly purified recombinant TDP-43 oligomers can reproduce this observed cell-type specific toxicity, providing further support to a protein oligomer-mediated toxicity hypothesis in ALS. In summary, we have developed a human, clinically relevant, and cell-type specific modelling platform that recapitulates key aspects of sporadic ALS and uncovers both an initial neuroprotective role for astrocytes and the cell type-specific toxic effect of TDP-43 oligomers.
title: Auswertung des peri- und postoperativen Verlaufs der verschiedenen Harnableitungen nach radikaler Zystektomie bei hochbetagten Patienten
Creators: name: Nikolov, Ivan
name: Kuhn, Christoph
name: Rohde, Detlef
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Das Durchschnittsalter der uroonkologischen Patienten in Deutschland steigt wie das demographische Durchschnittsalter kontinuierlich an (Schulzel at al. 2008). Reine Altersgrenzen für ein radikalchirurgisches Vorgehen haben aus unserer Sicht heute keinen Bestand mehr. Wir untersuchten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
title: Robotische Harnleiterneueinpflanzung in eine robotisch angelegte Neoblase
Creators: name: Roosen, Alexander
name: Heiland, Markus
name: Ubrig, Burkhard
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Stenosierungen der Harnleiter-Darm-Anastomose(n) nach Anlage einer Neoblase sind eine bekannte Spätkomplikation in der Harnableitungschirurgie. Die Versorgung im Sinne einer Neuanlage der Anastomose ist wegen der tiefen Lage im kleinen Becken und der üblicherweise vorhandenen ausgeprägten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
title: Zytoreduktive Nephrektomie versus alleinige systemische Therapie bei Patienten mit primär metastasierten sarkomatoid differenzierten Nierentumoren
Creators: name: Tully, Karl
name: Paciotti, Marco
name: Häuser, Lorine
name: Noldus, Joachim
name: Trinh, Quoc-Dien
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Bei der zytoreduktive Nephrektomie handelt es sich um ein etabliertes Verfahren bei primär metastasierten Nierentumoren. Der Stellenwert bei metastasierten, sarkomatoid differenzierten Nierentumoren ist bisher unklar. Ziel dieser Studie ist daher zu analysieren, welchen Einfluss die[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
title: METEOR Studie: Analyse des Gesamtüberlebens (OS) basierend auf der frühen Tumorvolumenreduktion (eTS) in der Phase III Studie von Cabozantinib (Cabo) versus Everolismus (Eve) beim fortgeschrittenen Nierenzellkarzinom (RCC)
Creators: name: Duran, I.
name: Maroto, P.
name: Suarez, C.
name: Castellano, D.
name: García del Muro, X.
name: Costa, L.
name: Martin-Couce, L.
name: Benzaghou, F.
name: Thomas, S.
name: Markby, D. W.
name: Choueiri, T. K.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In der Phase 3 Studie METEOR (NCT01865747) verbesserte Cabo signifikant das OS (median 21,4 vs 16,5 Monate (Mon); HR, 0,66; 95% CI, 0,53–0,83), das progressionsfreie Überleben (PFS) sowie das objektive Ansprechen (ORR) im Vergleich zu Eve bei Patienten (Pts) mit vorbehandeltem[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
title: Raucherstatus und PD-L1 mRNA-Expression als Marker für das Ansprechen auf eine neoadjuvante Chemotherapie bei Patienten mit muskelinvasivem Blasenkarzinom
Creators: name: Reike, Moritz
name: Jütte, Hendrik
name: Wirtz, Ralph
name: Kriegmair, Maximilian
name: Erben, Philipp
name: Tully, Karl
name: Weyerer, Veronika
name: Eckstein, Markus
name: Hartmann, Arndt
name: Wezel, Felix
name: Bolenz, Christian
name: Tannapfel, Andrea
name: Noldus, Joachim
name: Roghmann, Florian
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Patienten mit muskelinvasivem Blasenkarzinom (MIBC), die vor Radikaler Zystektomie (RC) eine neoadjuvante Chemotherapie (NAC) erhielten, zeigen ein verbessertes Gesamtüberleben. Die beste Prognose haben Patienten mit einem vollständigen pathologischen Regress (pCR). Aktive Raucher[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
Supplementary Material for: Einstellung von Ärzten gegenüber Komplementärmedizin in einer ländlichen Region der Schweiz: Ergebnisse einer Umfrage
Creators: name: Marszalek, G.
name: Torchetti, L.
name: Barth, J.
name: Wolf, U.
name: Frei-Erb, M.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Fragestellung: Im Zusammenhang mit der Einführung ambulanter KM-Sprechstunden am Regionalspital Burgdorf wurde die ärztliche Einstellung zu Komplementärmedizin (KM) untersucht. Weiterhin wurden der Anteil der Ärzte mit KM-Angeboten im Versorgungsgebiet des Regionalspitals, deren KM-Erfahrungen sowie der Einfluss dieser Erfahrungen auf die Einstellung gegenüber KM untersucht. Material und Methoden: Alle Ärzte jeglicher Fachrichtung (n = 170) im Versorgungsgebiet wurden 2011 und 2012 schriftlich zu ihrer Einstellung gegenüber KM (Befürwortung/Ablehnung und Ambivalenz), ihrem KM-Angebot und ihren KM-Erfahrungen befragt (Rücklaufquote 45% bzw. 36%). Ergebnisse: Die Einstellung gegenüber KM war im Durchschnitt neutral (M = 2,47, Standardabweichung (SD) = 0,61; Befürwortung von KM von 1 = «stimme völlig zu» bis 4 = «stimme überhaupt nicht zu») und klar (M = 1,59, SD = 0,46; Einstellungsambivalenz von 1 = «habe klare Meinung» bis 4 = «bin mir sehr unsicher in meiner Meinung»). Die höchste Zustimmung erhielten die Forderungen nach wissenschaftlicher Untersuchung der KM (M = 2,10, SD = 0,95) und nach zertifizierter ärztlicher KM in der Grundversicherung (M = 2,53, SD = 1,15). Knapp ein Drittel der Ärzte bot KM an, und 77% bzw. 69% überwiesen Patienten zu KM-Behandlungen. Die wichtigsten Prädiktoren der KM-Befürwortung waren eine zertifizierte KM-Ausbildung und unerwartete positive bzw. negative Verläufe unter einer KM-Behandlung (R2 2011 = 0,44, p < 0,001). 25% der Ärzte hatten Erfahrungen mit der neuen KM-Sprechstunde, die überwiegend positiv waren. Schlussfolgerung: Die teilnehmenden Ärzte aus einer ländlichen Region der Schweiz zeigten im Durchschnitt eine neutrale und klare Einstellung zur KM, die sich im eigenen KM-Angebot bzw. in der Überweisungspraxis spiegelte.
title: 3 kleine Schritte zur möglichen Anerkennung der Berufskrankheit „Harnblasenkarzinom“
Creators: name: Schöps, Wolfgang
name: Felten, Christian
name: Golka, Klaus
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Der Anteil der beruflich bedingten Harnblasenkarzinome wird auf 5–10% geschätzt. Die Anzahl der bisher als Berufskrankheit anerkannten Fälle müsste bis zu zwanzigfach höher sein. Für die vermutete hohe Dunkelziffer muss unter anderem auch die unzureichende[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
Personas for a better understanding of emerging worker identities in the Swiss Gig Economy
Creators: name: Ryser, Thomas
name: Flepp, Corsin
name: Konrad, Jonas
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: Gig Economy
Worker Identity
Job Biographies
Social Network Analysis

description: The present applied research project studied gig workers of the biggest platform company in Switzerland (around 180’000 users inscribed). To assess worker personas data were analyzed from 18 indepth interviews including the inquiry of worker biographies, their work related social network structures. The results show that platform workers can be differentiated according to the continuity in the perception of the work form. Gig workers seeing the work form as a transition phase in their vocational development can be distinguished from workers who have developed a mid- till long- term perspective in doing gig work. The classification of personas can be interpreted as a model of individual career paths in a highly volatile, new job environment, where new worker identities emerge.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Saulon-la-Chapelle et Saulon-la-Rue, Fénay, Noiron et la rivière Cent-fonds (XVe siècle), Cart. 179 (11 H 1075), 70 folios, f. 0139
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire de Cîteaux pour les possessions de Saulon-la-Chapelle et Saulon-la-Rue, Fénay, Noiron et la rivière Cent-fonds (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 179 (11 H 1075), 70 folios, f. 0139, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Saulon-la-Chapelle et Saulon-la-Rue, Fénay, Noiron et la rivière Cent-fonds (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 179 (11 H 1075), 70 folios, f. 0139, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Calcitonin related polypeptide alpha gene polymorphisms according to plasma total homocysteine levels in ischemic stroke patients of Trakya Region
Creators: name: Alkanli, Nevra
name: Tammam Sipahi
name: Ay, Arzu
name: Baburhan Guldiken
name: Bakir, Alev
name: Alkanli, Suleyman Serdar
name: Celebi, Canan
name: Atilgan, Emre
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The aim of this study was to determine the genotype distributions of calcitonin related polypeptide alpha (CALCA) gene polymorphisms according to the plasma total homocysteine levels in ischemic stroke patients and patient subtypes selected from Trakya Region. The study included 82 patients and 92 healthy controls. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine the genotype distributions of CALCA gene polymorphisms. The plasma total homocysteine levels were measured by Immulite 2000XPi homocysteine kits. Significant differences were not found between the group of patients and the control group in terms of CALCA gene polymorphisms genotype distributions (p > 0.05). Significant differences were not found between ischemic stroke patients and healthy controls, in the patient subtypes with ischemic stroke in respect to the CALCA gene polymorphisms genotype distributions according to the plasma total homocysteine levels (p > 0.05). This suggests that the CALCA gene polymorphisms genotype distributions studied according to the plasma total homocysteine levels could not likely be considered a genetic risk factor for ischemic stroke development.
title: Nichtmuskelinvasives Urothelkarzinom der Harnblase: Hyperthermale Intravesikale Chemotherapie mit Mitomycin 40mg (HIVEC)
Creators: name: Dimitroulis, Pantelis
name: Nzeh, Cajetan
name: Planz, Bernhard
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Das Harnblasenkarzinom ist mit 28.000 Neuerkrankungen pro Jahr das dritthäufigste Karzinom. Die Inzidenz ist steigend (30% innerhalb von 15 Jahren). Das neue Therapieverfahren HIVEC: hyperthermische intravesikale Chemotherapie mit Mitomycin wird nach transurethralen Blasentumoroperationen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
Rechtliche Informationen zu digitalen Medien für stationäre Einrichtungen der Jugendhilfe
Creators: name: Heeg, Rahel
Publisher: name: MEKis
Year: 2018
Subjects: Digitale Medien
Recht
Jugendhilfe

description: Zur rechtlichen Situation in Bezug auf Medien in der Kinder- und Jugendhilfe stellen sich vielfältige Fragen. Die unten angeführten verschiedenen Merkblätter geben einen knappen Überblick über die rechtliche Situation zu verschiedenen Fragen in Zusammenhang mit digitalen Medien und der Rolle von Einrichtungen der Kinder- und Jugendhilfe.
LC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extracts
Creators: name: Abdullah, Fuad O.
name: Muhammed, Haval H.
name: Yilmaz, Mustafa Abdullah
name: Cakir, Oguz
name: Tarhan, Abbas
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: The chemical composition of Nonea pulmonarioides extracts were investigated for the first time. The phytoconstituents of the methanol extracts were screened by using LC/MS-MS technique. The anticancer activity of the acetone and methanol extracts were measured against four cancer cell lines; MCF-7, PC3, HT-29, and U-87 MG. Thirty phenolic compounds were identified, rosmarinic (90.06 mg analyte/g extract) and fumaric acids (39.737 mg analyte/g extract) were major compounds of the studied species. Moreover, both methanol and acetone extracts were found to have strong anticancer activities. The acetone extract HT-29 (with IC50 of 10.17 ± 0.25 µg/mL) compared with standard cis-platin (with IC50 of 22.20 ± 0.72 µg/mL) with apoptotic mediated programmed cell death. These findings identified N. pulmonarioides as a potential species exhibiting anticancer properties. In conclusion, the compelling results show that the methanol extract contains possible bioactive compounds with anticancer properties that require isolation and further characterisation.
title: Blasenkarzinom als Spätfolge einer Querschnittlähmung. Vergleich klinischer Daten mit dem RKI-Zentrum für Krebsregisterdaten
Creators: name: Böthig, Ralf
name: Tiburtius, Christian
name: Fiebag, Kai
name: Hirschfeld, Sven
name: Thietje, Roland
name: Kurze, Ines
name: Kaufmann, Albert
name: Schöps, Wolfgang
name: Kadhum, Thura
name: Golka, Klaus
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Unterscheidet sich das Harnblasenkarzinom (HB-Ca.) bei querschnittgelähmten Patienten (spinal cord injury/disease; SCI/D) vom dem der Normalbevölkerung? Methode: Vergleich der Daten einer retrospektiven Single-Center-Auswertung von konsekutiven Patientendaten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
Multilingual Sentiment Analysis for a Swiss Gig
Creators: name: Pustulka, Elzbieta
name: Hanne, Thomas
name: Blumer, Eliane
name: Frieder, Manuel
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: subject: sentiment analysis
subject: machine learning application
subject: natural language processing
subject: gig economy
subject: 330 - Wirtschaft

description: We are developing a multilingual sentiment analysis solution for a Swiss human resource company working in the gig sector. To examine the feasibility of using machine learning in this context, we carried out three sentiment assignment experiments. As test data we use 963 hand annotated comments made by workers and their employers. Our baseline, machine learning (ML) on Twitter, had an accuracy of 0.77 with the Matthews correlation coefficient (MCC) of 0.32. A hybrid solution, Semantria from Lexalytics, had an accuracy of 0.8 with MCC of 0.42, while a tenfold cross-validation on the gig data yielded the accuracy of 0.87, F1 score 0.91, and MCC 0.65. Our solution did not require language assignment or stemming and used standard ML software. This shows that with more training data and some feature engineering, an industrial strength solution to this problem should be possible.
LC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extracts
Creators: name: Abdullah, Fuad O.
name: Muhammad, Haval H.
name: Yilmaz, Mustafa Abdullah
name: Cakir, Oguz
name: Tarhan, Abbas
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: The chemical composition of Nonea pulmonarioides extracts were investigated for the first time. The phytoconstituents of the methanol extracts were screened by using LC/MS-MS technique. The anticancer activity of the acetone and methanol extracts were measured against four cancer cell lines; MCF-7, PC3, HT-29, and U-87 MG. Thirty phenolic compounds were identified, rosmarinic (90.06 mg analyte/g extract) and fumaric acids (39.737 mg analyte/g extract) were major compounds of the studied species. Moreover, both methanol and acetone extracts were found to have strong anticancer activities. The acetone extract HT-29 (with IC50 of 10.17 ± 0.25 µg/mL) compared with standard cis-platin (with IC50 of 22.20 ± 0.72 µg/mL) with apoptotic mediated programmed cell death. These findings identified N. pulmonarioides as a potential species exhibiting anticancer properties. In conclusion, the compelling results show that the methanol extract contains possible bioactive compounds with anticancer properties that require isolation and further characterisation.
title: Prognostische Rolle von FGFR-Alterationen und FGFR-mRNA-Expression bei Patienten mit metastasiertem Urothelkarzinom unter immunonkologischer Therapie
Creators: name: Roghmann, Florian
name: Wirtz, Ralph M.
name: Santiago-Walker, Ademi
name: Jarczyk, Jonas
name: Kriegmair, Maximilian C.
name: Worst, Thomas S.
name: Sikic, Danijel
name: Wach, Sven
name: Taubert, Helge
name: Weyerer, Veronika
name: Stoehr, Robert
name: Tully, Karl
name: Zengerling, Friedemann
name: Bolenz, Christian
name: Breyer, Johannes
name: Burger, Maximilian
name: Porubsky, Stefan
name: Hartmann, Arndt
name: Erben, Philipp
name: Eckstein, Markus
name: Jütte, Hendrik
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Im Zeitalter der individualisierten onkologischen Therapie wurden FGFR3 Mutationen, FGFR2 und FGFR3 Genefusionen und darüber hinaus FGFR-mRNA-Expression als potentielle onkologische Targetstrukturen und ihre Assoziation zu anti-PD-1 und anti-PD-L1 (IO) Therapieergebnissen in einer Multicenter-Patientenkohorte[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie
Mit Körpereinsatz den Zahlenstrahl erschliessen
Creators: name: Högger, Dominique
name: Royar, Thomas
Publisher: name: Aulis
Year: 2015
Subjects: subject: Zahlenreihe
subject: Mathematikdidaktik
subject: Bewegtes Lernen
subject: Raumorientierung
subject: Anschauungsmittel
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Vielen Menschen erscheint die Zahlenreihe als räumliches Bild vor dem inneren Auge, Rechenschritte werden als Bewegungen in einem virtuellen Raum vorgestellt. Dies legt nahe, Körper- und Raumorientierung gezielt zu nutzen, um die Vorstellung von Zahlen breiter zu verankern und besser zu vernetzen. Der Beitrag stellt grundsätzliche Überlegungen sowie Praxisvorschläge vor.
title: Essays on corporate financial management in shipping: capital structure and M&As choices, interactions between corporate decisions, and funding conditions on M&As guality
Creators: name: Gülnur, Arman
Publisher: name: University of Reading
Year: 2022

description: This thesis provides a comprehensive understanding of corporate financial management in the shipping industry by conducting three in-depth analyses on shipping finance. The first analysis is focused on the relations between capital structure and inorganic investment decisions in the shipping industry by utilising a series of state-of-the-art methods. The study reveals how financial leverage has an impactful effects on shipping companies’ Mergers and Acquisitions (M&As) decisions. Deviations from target leverage display a strong association with the probability of being an acquirer, while deal size, method of payment and deal outcomes are strongly affected. Excessive debt in the financing mix decreases the likelihood of consummating acquisitions but increases the deal quality, indicating direct policy implications for several actors in the shipping industry. The second analysis regards the interactions between investment, financing, and payout choices in the shipping industry. The study highlights the importance of utilising a correct methodology when explaining the relations between the three important corporate policies. Failing to consider the endogeneity and simultaneity leads to a severe underestimation of the co-determination of investment, financing, and payout. Simultaneous equations approach is found to be the best approach to unearth the relations, while financial constraints and the phases in the shipping cycles cause significant divergences in how the three corporate decisions interact with one another. The co-determination of corporate decisions in shipping companies is found to be much more pronounced, emphasising how capital intensiveness and high debt reliance can expose significant interactions between investment, financing, and payout. The third analysis revisits the acquirer returns in the shipping industry by taking aggregate funding conditions into account. The study begins by investigating how different phases of aggregate IV funding conditions affect the deal quality in the shipping industry. The acquirer returns are found to be decreasing with improving funding conditions, implying that shipping companies are less cautious in selecting targets in favourable funding conditions. However, industry-level earnings seem to significantly moderate the negative relationship, emphasising the impact of a positive shock to the industry on the M&As market in the shipping industry. Shipping M&As are found to be vulnerable to global economic policy uncertainty along with favourable funding conditions, implying that M&A returns are hampered by uncertainty. However, M&A record and free cash flow (FCF) levels seem to have a positive impact on M&A returns in accommodative funding environments.
The Latest in Mastitis Control and Manageinent
Creators: name: Johnson, Andrew P.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: This is a very interesting topic because there have not been major changes in mastitis control and management. The secret is still to pay attention to the "Mastitis Triangle," which means looking at the people milking the cows, the equipment, and the cow's environment. The most successful milk quality programs are those that look at the whole picture. Instead of dealing with problem high-somatic cell count (SCC) herds, the biggest opportunities are with well-managed dairies trying to improve their milk quality program. These dairies want to milk more cows in less time, and control clinical mastitis and SCC. Working to change lag times for better let-downs, having the right vacuum in the claw during peak milk flow or changing automatic take-off (ATO) settings to shorten milking duration are ways to change milking performance. Assisting the farm to develop better cow traffic patterns and faster loading will also improve the performance. By improving milk quality you can affect the profitability of a dairy. There is no one better to accomplish this than a large animal veterinarian. The opportunity is huge for those that are willing to get involved with their dairy farms.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
title: Valid Presumption of Shiga Toxin-Mediated Damage of Developing Erythrocytes in EHEC-Associated Hemolytic Uremic Syndrome
Creators: name: Detzner, Johanna
name: Pohlentz, Gottfried
name: Müthing, Johannes
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 610 Medicine and health

description: The global emergence of clinical diseases caused by enterohemorrhagic Escherichia coli (EHEC) is an issue of great concern. EHEC release Shiga toxins (Stxs) as their key virulence factors, and investigations on the cell-damaging mechanisms toward target cells are inevitable for the development of novel mitigation strategies. Stx-mediated hemolytic uremic syndrome (HUS), characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal injury, is the most severe outcome of an EHEC infection. Hemolytic anemia during HUS is defined as the loss of erythrocytes by mechanical disruption when passing through narrowed microvessels. The formation of thrombi in the microvasculature is considered an indirect effect of Stx-mediated injury mainly of the renal microvascular endothelial cells, resulting in obstructions of vessels. In this review, we summarize and discuss recent data providing evidence that HUS-associated hemolytic anemia may arise not only from intravascular rupture of erythrocytes, but also from the extravascular impairment of erythropoiesis, the development of red blood cells in the bone marrow, via direct Stx-mediated damage of maturing erythrocytes, leading to "non-hemolytic" anemia.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells
Creators: name: Yizhong Liu
name: Rogel, Noga
name: Harada, Kei
name: Leigha Jarett
name: Maiorana, Christopher H.
name: German, Guy K.
name: Mahler, Gretchen J.
name: Doiron, Amber L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and function beyond the influence on cell viability. Five types of gold nanoparticles were studied: 5 nm and 20 nm bare gold nanoparticles, 5 nm and 20 nm gold nanoparticles with biocompatible polyethylene glycol (PEG) coating and 60 nm bare gold nanoparticles. We found that all tested gold nanoparticles did not affect cell viability significantly and reduced the reactive oxygen species (ROS) level in endothelial cells. Only 20 nm bare gold nanoparticles caused an over 50% increase in endothelial barrier permeability and slow recovery of barrier function was observed after the gold nanoparticles were removed. This impairment in endothelial barrier function was caused by unbalanced forces between intracellular tensions and paracellular forces, actin microfilament rearrangement, which occurred through a Rho/ROCK kinase-dependent pathway and broke the force balance between intracellular tensions and paracellular forces. The size-specific effect of gold nanoparticles on endothelial cells may have important implications regarding the behavior of nanoparticles in the biological system and provide valuable guidance in nanomaterial design and biomedical applications.
Dealing with Downers
Creators: name: Reynolds, Jim
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: "Down cattle" are non-ambulatory cattle that cannot stand or walk without assistance. Down cattle present welfare, food safety and economic problems to the cattle industry. Decisions must be made quickly to either care for non-ambulatory livestock properly or to humanely euthanize them. USDA estimated that approximately 200,000 down cattle were presented to slaughter facilities in the US in 2003, and that almost 5% of dairy cattle became non-ambulatory in 2005. Causes are injuries related to dystocia, infectious diseases (toxic mastitis, toxic metritis, lymphoma, peritonitis, septicemia) and metabolic disorders (hypocalcemia, hypomagnesmia, hypophosphatemia, hypokalemia, acidosis). If the animal is suffering and the pain or distress cannot be controlled or is not likely to be controlled quickly, the animal should be euthanized. Treatment includes nursing care that provides comfortable bedding, shelter, food and water, and protection from other cattle and wildlife as well as medical care. Down cattle can be moved on sleds, belts or carefully in tractor buckets, but should not be dragged except in emergency situations. Non-ambulatory cattle cannot be left without water, feed and shelter. Public health issues involve increasing pathogen loads (salmonella, E. coli, and Bovine Spongiform Encephalopathy (BSE)) and tissue residues at slaughter. Current USDA rules curtail the slaughter of down cattle in the US. Economic costs relate to replacement, treatment and nursing care, and potential effects on milk and meat markets (consumer acceptance); 77% of consumers polled replied that they found it unacceptable that downed animals were used for food.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
title: Flow Manifold for Automated On-Line Dilution of Standards for Flame Atomic Absorption Spectrometry and Its Use in a Null Measurement Method
Creators: name: Bysouth, S. R.
name: Tyson, Julian
Publisher: name: University of Massachusetts Amherst
Year: 1987
Subjects: subject: Automated calibration
subject: flame atomic absorption spectrometry
subject: on-line dilution
subject: null measurement method
subject: Chemistry

description: A flow manifold that automatically dilutes solutions presented to a flame atomic absorption spectrometer while maintaining a constant flow to the nebuliser is described. The manifold is based on a fixed-speed pump, together with a computer-controlled stream switching valve and pump. The computer is also used for data acquisition and handling. In addition to the production of solutions for a conventional calibration procedure, the system is also used for a novel calibration procedure whereby the stock standard solution is automatically diluted by a known factor until its absorbance matches that of the sample. This null measurement method avoids the need to fit a curve to a set of calibration points. The performance of both methods compares favourably with the conventional procedure with errors ranging from 0.0 to 4% and no significant bias at the 99% confidence level. Problems with pulsations in the flow caused by peristaltic pump rollers were encountered with the consequent difficulties of accurate flow-rate measurement. Attempts to improve the speed of the method by the use of flow injection introduction were not successful owing to these pulsations in the flow.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Cart. 184 (11 H 987), 105 folios, f. 0095
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP

description: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0095, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0095, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Building Better Barns
Creators: name: Weary, Daniel M.
name: Von Keyserlingk, Marina A. G.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Design and management of the feeding area are important. High stocking densities at the feed bunk increase aggressive competition and keep subordinate cows away from feed. Physical barriers between cows, including head lockers and feed stalls, can help reduce this competition and increase feeding time. Cows like softer surfaces, for both lying down and for standing upon. Deep-bedded stalls work well for cow comfort, but require maintenance. When it comes to physical structures used to build freestalls, less is more - the hardware we place in the stall is for our benefit, and not the cow's. The more restrictive we design stalls, the less attractive they become for the cow. Use of restrictive stall designs can help keep stalls clean, but to avoid problems with hoof health these designs need to be accompanied by better flooring options, such as softer and drier flooring.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Kriterien‐Kriterienpunkte‐Indikatoren – ihr Stellenwert im inklusiv‐nutzungsfokussierten Forschungsmodus – entschlüsselt aus evaluationswissenschaftlicher Sicht
Creators: name: Beywl, Wolfgang
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2022
Subjects: subject: Evaluation
subject: Transdisziplinäre Forschung
subject: Nachhaltigkeit
subject: Indiaktor
subject: Kriterium
subject: Wert
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Der Beitrag behandelt Kriterien und Indikatoren im Zusammenhang mit der Bewertung von Nachhaltigkeit und versucht eine begriffliche Klärung. Hintergrund sind evaluationstheoretische Überlegungen. Ausgangsthese ist, dass hinter Zielkonflikten von zu evaluierenden Projekten oder auch der Transdisziplinären Forschung selbst oft Wertkonflikte liegen. Diese materialisieren sich in Kriterien, die miteinander konkurrieren können. Ziele sind eine wichtige Quelle für Kriterien. Es gibt aber auch andere im Beitrag angesprochene Quellen. Vorgestellt werden zwei Sichtweisen: einerseits, dass die Bewertung von Nachhaltigkeit zum Beispiel politischer Massnahmen durch Forschung – aktiv – erfolgt, dass sie andererseits selbst – passiv - bewertet wird, also Bewertung von Forschung, u.a. bezüglich ihrer Nachhaltigkeit. Beide Linien werden im Beitrag angesprochen. Sie sind in der Transdisziplinären Forschung komplex verwickelt. Dies zu entwirren, beabsichtigt die Präsentation.
Differential gene expression in primary fibroblasts induced by proton and cobalt-60 beam irradiation
Creators: name: Nielsen, Steffen
name: Bassler, Niels
name: Grzanka, Leszek
name: Swakon, Jan
name: Olko, Pawel
name: Andreassen, Christian Nicolaj
name: Overgaard, Jens
name: Alsner, Jan
name: Sørensen, Brita Singers
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Introduction: Proton beam therapy delivers a more conformal dose distribution than conventional radiotherapy, thus improving normal tissue sparring. Increasing linear energy transfer (LET) along the proton track increases the relative biological effectiveness (RBE) near the distal edge of the Spread-out Bragg peak (SOBP). The severity of normal tissue side effects following photon beam radiotherapy vary considerably between patients. Aim: The dual study aim was to identify gene expression patterns specific to radiation type and proton beam position, and to assess whether individual radiation sensitivity influences gene expression levels in fibroblast cultures irradiated in vitro. Methods: The study includes 30 primary fibroblast cell cultures from patients previously classified as either radiosensitive or radioresistant. Cells were irradiated at three different positions in the proton beam profile: entrance, mid-SOBP and at the SOBP distal edge. Dose was delivered in three fractions × 3.5 Gy(RBE) (RBE 1.1). Cobalt-60 (Co-60) irradiation was used as reference. Real-time qPCR was performed to determine gene expression levels for 17 genes associated with inflammation response, fibrosis and angiogenesis. Results: Differences in median gene expression levels were observed for multiple genes such as IL6, IL8 and CXCL12. Median IL6 expression was 30%, 24% and 47% lower in entrance, mid-SOBP and SOBP distal edge groups than in Co-60 irradiated cells. No genes were found to be oppositely regulated by different radiation qualities. Radiosensitive patient samples had the strongest regulation of gene expression; irrespective of radiation type. Conclusions: Our findings indicate that the increased LET at the SOBP distal edge position did not generally lead to increased transcriptive response in primary fibroblast cultures. Inflammatory factors were generally less extensively upregulated by proton irradiation compared with Co-60 photon irradiation. These effects may possibly influence the development of normal tissue damage in patients treated with proton beam therapy.
Parasite DNA detection in water samples enhances crayfish plague monitoring in asymptomatic invasive populations
Creators: name: Sieber, Natalie
name: Hartikainen, Hanna
name: Krieg, Raphael
name: Zenker, Armin
name: Vorburger, Christoph
Publisher: name: Springer
Year: 2021
Subjects: Aphanomyces astaci
Invasive crayfish
Environmental DNA
Pathogen monitoring

description: Invasive species can facilitate the spread of pathogens by first providing asymptomatic host reservoirs, and then driving disease outbreaks in native populations through pathogen spillover. An example of this are invasive crayfish species in Europe (Faxonius limosus, Pacifastacus leniusculus, Procambarus clarkii), which carry the deadly plague agent (Aphanomyces astaci). Effective disease management requires comprehensive monitoring, however, pathogen detection in carrier populations with low pathogen prevalence and intensities is challenging. We simultaneously collected and analysed crayfish tissue samples of invasive crayfish populations and water samples to compare A. astaci detection in different sample types using quantitative PCR. Combined, the two sampling methods revealed A. astaci presence with DNA concentrations above limit of detection (LOD; the lowest concentration which can be detected with reasonable certainty) in 13 of 23 invasive crayfish populations. In four additional sites, A. astaci DNA concentrations below LOD were found in water. In four populations only were A. astaci concentrations above LOD detected in both sample types and in three populations in concentrations above LOD in tissue but below LOD in water. The likely reason for these discrepancies is the low A. astaci prevalence and concentration in resistant invasive crayfish, which limit detection reliability. Consistency may be improved by timing surveys with seasonal periods of high A. astaci abundance and by increasing water sampling effort. Considering the ease of collecting eDNA samples, compared to crayfish tissue sampling, eDNA methods would facilitate frequent and comprehensive surveys. However, remaining uncertainties in eDNA-based detection reveal the relevance of combining monitoring tools to improve detection of invasive pathogens and their management.
Ovarian Responses to Treatment of Non-Lactating Cycling Holstein Cows with a Combination of Progesterone and Either GnRH or Oestradiol Benzoate, Injected at Diestrus
Creators: name: Segwagwe, B. V. E.
name: Macmillan, K. L.
name: Mansell, P. D.
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: Treatment of cycling cows with GnRH or ODB at the time of CIDR device insertion during diestrus (day 13) caused follicular turnover and a synchronized emergence of a new follicular wave. This follicular wave emerged earlier in GnRH than in ODBtreated cows. Following the synchronized emergence of a new wave, there was a synchronized onset of estrus and ovulation. The onset of estrus and ovulation were not influenced by treatment. ODB caused atresia of every second dominant follicle, while GnRH could not consistently ovulate this second dominant follicle. The inability of GnRH to consistently cause follicular turnover may be a limitation to its use.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Commingling Dairy Cows
Creators: name: Nordlund, Ken
name: Cook, Nigel
name: Oetzel, Garrett
Publisher: name: American Association of Bovine Practitioners  Proceedings of the Annual Conference
Year: 2006

description: In modern confinement dairies, cows move between groups depending on management needs for special rations and special handling requirements. With each move, each cow must establish rank within the new group. Extended stays in pens characterized by new arrivals every day appear to present substantial health risks to some cows. Overstocked pens present challenges regarding both stall and feed bunk access. Provision of 30 inches (76 cm) of bunk space per cow in the weeks before and after calving, and minimizing pen moves, appears to be consistent with improved fresh cow health and productivity.
description: American Association of Bovine Practitioners Proceedings of the Annual Conference, 2006
Ninna Edgardh: Diakonins kyrka
Creators: name: Leis-Peters, Annette
Publisher: name: Tidsskrift for Praktisk Teologi
Year: 2022

description: Diakonins kyrka: Teologi, Kön och omsorgens utmattning
description: Tidsskrift for Praktisk Teologi, Vol 39 Nr 1 (2022): Tidsskrift for praktisk teologi