cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Determination of tricyclic antidepressants in human urine samples by the three-step sample pretreatment followed by HPLC-UV analysis
title: an efficient analytical method for further pharmacokinetic and forensic studies
titleType: AlternativeTitle
Creators: name: Mohebbi, Ali
name: Farajzadeh, Mir Ali
name: Yaripour, Saeid
name: Afshar Mogaddam, Mohammad Reza
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Tricyclic antidepressant
subject: Sample pretreatment
subject: High performance liquid chromatography–ultraviolet detection
subject: Urine
subject: 610

description: In this work, an efficient sample pretreatment method has been developed by combining salt induced– homogenous liquid–liquid extraction, dispersive solid phase extraction, and dispersive liquid–liquid microextraction based on the solidification of floating organic droplet for the extraction of some widely used tricyclic antidepressant (TCA) drugs (nortriptyline, amitriptyline, desipramine, clomipramine, and imipramine) in human urine samples before their determination by high performance liquid chromatography–ultraviolet detection. In brief, the target analytes are first isolated from urine samples into acetonitrile (ACN) separated by adding a salt. Then the obtained ACN phase is treated with a mixture of appropriate sorbents to remove interferences. Afterward, the purified ACN is mixed with menthol as an extractant and rapidly injected into alkaline HPLC–grade water as a preconcentration step. Next, the obtained solution is placed in an ice bath and menthol collects on top of the solution after solidification. The solidified drop is then withdrawn and injected into separation system after dissolving in 10 μL ACN. Under the optimum experimental conditions, extraction recoveries and enrichment factors of the selected drugs ranged from 69–84 % and 345–420, respectively. The limits of detection and quantification were obtained at the ranges of 0.22–0.31, and 0.71–1.1 μg L–1, respectively. The relative standard deviations of the proposed method were ≤ 6 % for intra– (n=6) and inter–day (n=4) precisions at a concentration of 10 μg L–1 (each drug). Finally, the suggested approach was applied to determine of TCA drugs in different patients' urine samples. The method could be applied in further TCAs pharmacokinetic and forensic studies.
description: EXCLI Journal;Vol. 17 2018
title: Το προφίλ του οικονομικού μετανάστη στην Ελλάδα με βάση στοιχεία της απογραφής πληθυσμού των ετών 2001 και 2011
title: The profile of economic immigrants in Greece based on the 2011 population census
titleType: AlternativeTitle
Creators: name: Κιρμίτσα, Δέσποινα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Προφίλ οικονομικού μετανάστη
subject: Πληθυσμός
subject: Δημογραφία
subject: Απογραφικά δεδομένα
subject: Μετανάστευση
subject: Οικονομικά στοιχεία

description: Οι μεταναστευτικές ροές σε κάθε χώρα επηρεάζουν άμεσα την κατανομή του γηγενούς πληθυσμού καθώς και κλάδους όπως η οικονομία, η εργασία, η εκπαίδευση κ.α. Για το λόγο αυτό η μελέτη και η καταγραφή των ατόμων που εισρέουν σε μια χώρα είναι σημαντική. Στην παρούσα εργασία θα γίνει μελέτη αναφορικά με τις μεταναστευτικές ροές προς την Ελλάδα από στοιχεία που συλλέχθηκαν από τις απογραφές των ετών 2001 και 2011. Μέσω των δεδομένων αυτών, θα εξαχθούν τα χαρακτηριστικά τους για τα έτη αυτά, τα οποία και θα αναλυθούν εκτενώς. Ιδιαίτερη βαρύτητα θα δοθεί στα δεδομένα εκείνα τα οποία αφορούν τα οικονομικά χαρακτηριστικά του πληθυσμού για κάθε έτος απογραφής ξεχωριστά. Εν συνεχεία σκοπός της παρούσας εργασίας είναι να γίνει σύγκριση των δύο απογραφών και ιδιαίτερα των διαφοροποιήσεων που εμφάνισαν οι μεταναστευτικές ροές ανάμεσα στις δύο προαναφερθέντες απογραφές. Τέλος θα εξαχθούν τα συμπεράσματα αναφορικά με τις διαφοροποιήσεις κυρίως των οικονομικών χαρακτηριστικών του μετανάστη που εισήλθε στην Ελλάδα από το έτος 2001 έως το 2011
Simultaneous determination of sarcosine and its related metabolites by gas chromatography-tandem mass spectrometry for prostate cancer diagnosis
Creators: name: Yamkamon, Vichanan
name: Yee, Pyone Pyone
name: Yainoi, Sakda
name: Eiamphungporn, Warawan
name: Suksrichavalit, Thummaruk
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Gas chromatography-tandem mass spectrometry
subject: Sarcosine
subject: Alanine
subject: Glycine
subject: Creatinine
subject: MRM
subject: 610

description: Shortly after sarcosine was delineated as a potential biomarker for prostate cancer in 2009, a variety of analytical methods for clinical application were developed. Moreover, higher uptake of glycine in the mitochondria also played a role in cancer proliferation. A major constraint in the accurate quantification of sarcosine was the interference of the two isomers, α-alanine and β-alanine, using chromatographic separation techniques. Accordingly, we aimed to develop an analytical method for determining sarcosine and its related metabolites (α- and β-alanine, glycine and creatinine) under the same conditions by gas chromatography-tandem mass spectrometry (GCMS/ MS). BSTFA + 1 % TMCS was used for silylation, and GC-MS/MS conditions were optimized for the target analytes. The unique transition ions of sarcosine, α- and β-alanine, glycine and creatinine set up in MRM acquisition were m/z 116 → 73, 190 → 147, 176 → 147, 176 → 147 and 100 → 73, respectively. This newly developed method was successfully validated to apply in clinical settings with low limits of detection (0.01 - 0.03 μg•mL-1), high correlations (R2 > 0.99), great accuracy (88 – 110 % recovery), and notable precision (RSD < 10 %). All TMS derivatives were > 80 % stable for up to 2 h after derivatization and analyzing during this period promises to achieve an accurate result. Monitoring the five-substance profile could enhance prospects for early diagnosis of prostate cancer.
description: EXCLI Journal;Vol. 17 2018
JWST Transit Spectra II: Constraining Aerosol Species, Particle-size Distributions, Temperature, and Metallicity for Cloudy Exoplanets
Creators: name: Lacy, Brianna
name: Burrows, Adam
Publisher: name: arXiv
Year: 2020
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: JWST will provide moderate resolution transit spectra with continuous wavelength coverage from the optical to the mid-infrared for the first time. In this paper, we illustrate how different aerosol species, size-distributions, and spatial distributions encode information in JWST transit spectra. We use the transit spectral modeling code METIS, along with Mie theory and several flexible treatments of aerosol size and spatial distributions to perform parameter sensitivity studies, calculate transit contribution functions, compute Jacobians, and retrieve parameters with Markov Chain Monte Carlo. The broader wavelength coverage of JWST will likely encompass enough non-gray aerosol behavior to recover information about the species and size-distribution of particles, especially if distinct resonance features arising from the aerosols are present. Within the JWST wavelength range, the optical and mid-infrared typically provide information about 0.1-1 $μ$m sized aerosols, while the near-infrared to mid-infrared wavelengths usually provide information about gaseous absorption, even if aerosols are present. Strong gaseous absorption features in the infrared often remain visible, even when clouds and hazes are flattening the optical and NIR portion of the spectrum that is currently observable. For some combinations of aerosol properties, temperature, and surface gravity, one can make a precise measure of metallicity despite the presence of aerosols, but more often the retrieved metallicity of a cloudy or hazy atmosphere has significantly lower precision than for a clear atmosphere with otherwise similar properties. Future efforts to securely link aerosol properties to atmospheric metallicity and temperature in a physically motivated manner will ultimately enable a robust physical understanding of the processes at play in cloudy, hazy exoplanet atmospheres.
description: submitted to ApJ; main paper: 29 pages, 18 figures, 4 tables; appendix: 17 pages, 20 figures
Risk factors and prevalence of toxocariasis in pregnant women and diabetic patients compared to healthy adults in Ilam province, western Iran
Creators: name: Raissi, Vahid
name: Sohrabi, Zahra
name: Getso, Muhammad
name: Raiesi, Omid
name: Hashemi Hafshejani, Saeideh
name: Shabandoust, Hajar
name: Etemadi, Soudabeh
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Toxocariasis
subject: Pregnancy
subject: Diabetic patients
subject: Ilam
subject: Iran
subject: 610

description: Toxocara is one of the common intestinal nematodes in dogs and cats and is the agent of tissue migratory larvae in humans. Customarily, the prevalence of human toxocariasis hovers around 15.8 % in Iran. Furthermore, other research outcomes demonstrated a tendency for an outbreak of toxocariasis in Iran. Therefore, we carried out a cross-sectional study and assessed the seroprevalence of toxocariasis humans in Ilam Province, western of Iran. A total of 539 serum samples were collected between September 2017 and March 2018 from patients referred to the Health Centers of Ilam province, Iran. Serum samples were investigated for the presence of Toxocara using IgG antibodies, ELISA (Enzyme-Linked Immunosorbent Assay) kit. Risk factors such as contact with cats and dogs, living in rural areas were investigated among the study population. Out of 539 total samples collected, 97 cases (17.99 %) were positive for anti-toxocara IgG antibodies. These antibodies were recovered from serum samples of otherwise healthy adults (15.54 %, 49/296), pregnant women (21.16 %, 40/189) and diabetic patients (14.81 %, 8/54). This study showed significant relationship between toxocariasis and contact with animal pets in all studied groups (P value ≤ 0.05) and a significant relationship between toxocariasis and living in rural areas among pregnant women (P value ≤ 0.05).
description: EXCLI Journal;Vol. 17 2018
Rotating Boson Stars and Q-Balls
Creators: name: Kleihaus, Burkhard
name: Kunz, Jutta
name: List, Meike
Publisher: name: arXiv
Year: 2005
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider axially symmetric, rotating boson stars. Their flat space limits represent spinning Q-balls. We discuss their properties and determine their domain of existence. Q-balls and boson stars are stationary solutions and exist only in a limited frequency range. The coupling to gravity gives rise to a spiral-like frequency dependence of the boson stars. We address the flat space limit and the limit of strong gravitational coupling. For comparison we also determine the properties of spherically symmetric Q-balls and boson stars.
description: 22 pages, 18 figures
Mixed-ligand metal-organic frameworks and heteroleptic coordination cages as multifunctional scaffolds - a comparison
Creators: name: Pullen, Sonja
name: Clever, Guido H.
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Supramolecular chemistry
subject: MOFs
subject: MOCs
subject: Multifunctionality
subject: Coordination cages
subject: Metal-mediated self assembly
subject: 540

description: Porous nanostructures and materials based on metal-mediated self-assembly have developed into a vibrantly studied subdiscipline of supramolecular chemistry during the past decades. In principle, two branches of such coordination compounds can be distinguished: Metal–organic frameworks (MOFs) on the one side represent infinite porous networks of metals or metal clusters that are connected via organic ligands to give solid-state materials. On the other hand, metal–organic cages (MOCs) are discrete and soluble systems with only a limited number of pores. Formation of a particular structure type is achieved by carefully balancing the donor site angles within the ligands as well as the nature and coordination geometry of the metal component. Years of research on MOFs and MOCs has yielded numerous types of well-defined porous crystals and complex supramolecular architectures. Since various synthetic routes and postsynthetic modification methods have been established, the focus of recent developments has moved toward the preparation of multifunctional systems that are able to mimic the structural and functional complexity of natural enzymes.
A single-step third-order temporal discretization with Jacobian-free and Hessian-free formulations for finite difference methods
Creators: name: Lee, Youngjun
name: Lee, Dongwook
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computational Physics (physics.comp-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Numerical Analysis (math.NA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Discrete updates of numerical partial differential equations (PDEs) rely on two branches of temporal integration. The first branch is the widely-adopted, traditionally popular approach of the method-of-lines (MOL) formulation, in which multi-stage Runge-Kutta (RK) methods have shown great success in solving ordinary differential equations (ODEs) at high-order accuracy. The clear separation between the temporal and the spatial discretizations of the governing PDEs makes the RK methods highly adaptable. In contrast, the second branch of formulation using the so-called Lax-Wendroff procedure escalates the use of tight couplings between the spatial and temporal derivatives to construct high-order approximations of temporal advancements in the Taylor series expansions. In the last two decades, modern numerical methods have explored the second route extensively and have proposed a set of computationally efficient single-stage, single-step high-order accurate algorithms. In this paper, we present an algorithmic extension of the method called the Picard integration formulation (PIF) that belongs to the second branch of the temporal updates. The extension presented in this paper furnishes ease of calculating the Jacobian and Hessian terms necessary for third-order accuracy in time.
Roles of Rubella virus nonstructural proteins in RNA replication
Creators: name: Wang, Xiaojie
Publisher: name: University of British Columbia
Year: 2009

description: Rubella virus (RV) is an enveloped, positive-strand RNA virus in the family Togaviridae. The 9759-nucleotide genomic RNA contains two long open reading frames (ORFs). Onethird of the 3'-proximal ORF encodes the three structural proteins required for virus assembly. The other two-thirds encode the nonstructural proteins (NSPs) that function in RNA replication. The primary NSP polyprotein p200 is cleaved by a viral encoded protease into pi50 and p90. The aim of my thesis project is to identify the functional roles of NSPs in RV replication with respect to individual NSPs required for plus-strand RNA synthesis and the effect of highly conserved GDD motif within p90 region on viral replication. Both protease-inactive (pBRM33/Cl 152S) and cleavage-defective (pBRM33/G1301S) mutants can initiate minus-strand RNA but not plus-strand RNA synthesis (Liang and Gillam, 2000). In this study, individual RV NSPs were expressed by either a recombinant vaccinia virus or by co-electroporation of helper genomes. Complementation experiments were carried out by providing individual RV NSPs with either pBRM33/C1152S or pBRM33/G1301S mutant as a template. Rescue of pBRM33/C1152S by either p200 or pi50 indicates that functional protease can be provided in trans. Rescue of pBRM33/G1301S by either p200 or pl50/p90 suggests that the pl50/p90 replication complex functions in plus-strand RNA synthesis. Site-directed mutagenesis was employed to investigate the effect of putative RV RNAdependent RNA polymerase GDD motif on viral replication. Substitution of glycine by alanine (G1966A) resulted in impaired virus infectivity, reduced by 1.7xl0⁴-fold. Alteration of either aspartate residue completely abolished virus replication. A revertant was isolated from the passaged G1966A virus and its sequence confirmed. These results are consistent with the prediction that p90 is the RdRp of RV.
The Inclination Angle of and Mass of the Black Hole in XTE J1118+480
Creators: name: Gelino, Dawn M.
name: Balman, Solen
name: Kizilouglu, Umit
name: Yilmaz, Arda
name: Kalemci, Emrah
name: Tomsick, John A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have obtained optical and infrared photometry of the quiescent soft X-ray transient XTE J1118+480. In addition to optical and J-band variations, we present the first observed H- and K_s-band ellipsoidal variations for this system. We model the variations in all bands simultaneously with the WD98 light curve modeling code. The infrared colors of the secondary star in this system are consistent with a K7V, while there is evidence for light from the accretion disk in the optical. Combining the models with the observed spectral energy distribution of the system, the most likely value for the orbital inclination angle is 68 +/- 2 deg. This inclination angle corresponds to a primary black hole mass of 8.53 +/- 0.60 M_sun. Based on the derived physical parameters and infrared colors of the system, we determine a distance of 1.72 +/- 0.10 kpc to XTE J1118+480.
description: 6 pages, 3 figures, To appear in ApJ 01 May 2006 issue
Rational design of an amphiphilic coordination cage-based emulsifier
Creators: name: Saha, Subhadeep
name: Holzapfel, Björn
name: Chen, Yen-Ting
name: Terlinden, Kai
name: Lill, Pascal
name: Gatsogiannis, Christos
name: Rehage, Heinz
name: Clever, Guido H.
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Amphiphiles
subject: Surfactants
subject: Emulsions
subject: Coordination chemistry
subject: Supramolecular chemistry
subject: Self-assembly
subject: In situ liquid phase TEM
subject: 540

description: Self-assembled, porous coordination cages with a functional interior find application in controlled guest inclusion/release, drug delivery, separation processes, and catalysis. However, only few studies exist that describe their utilization for the development of self-assembled materials based on their 3-dimensional shape and external functionalization. Here, dodecyl chain-containing, acridone-based ligands (LA) and shape-complementary phenanthrene-derived ligands (LB) are shown to self-assemble to heteroleptic coordination cages cis-[Pd2(LA)2(LB)2]4+ acting as a gemini amphiphile (CGA-1; Cage-based Gemini Amphiphile-1). Owing to their anisotropic decoration with short polar and long nonpolar side chains, the cationic cages were found to assemble into vesicles with diameters larger than 100 nm in suitable polar solvents, visualized by cryo-TEM and Liquid-Cell Transmission Electron Microscopy (LC-TEM). LC-TEM reveals that these vesicles aggregate into chains and necklaces via long-range interactions. In addition, the cages show a rarely described ability to stabilize oil-in-oil emulsions.
title: A haplotype of the phosphodiesterase 4D (PDE4D) gene is associated with myocardial infarction and with cardiometabolic parameters
title: the GEA study
titleType: AlternativeTitle
Creators: name: Rodríguez-Pérez, José Manuel
name: Posadas-Sánchez, Rosalinda
name: Blachman-Braun, Ruben
name: Vargas-Alarcón, Gilberto
name: Posadas-Romero, Carlos
name: García-Flores, Esbeidy
name: López-Bautista, Fabiola
name: Tovilla-Zárate, Carlos Alfonso
name: González-Castro, Thelma Beatriz
name: Borgonio-Cuadra, Verónica Marusa
name: Pérez-Hernández, Nonanzit
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Phosphodiesterase
subject: Myocardial infarction
subject: Polymorphisms
subject: Mexican population
subject: 610

description: The phosphodiesterase family is involved in a wide spectrum of diseases, including ischemic stroke. However, few studies have analyzed the relationship between phosphodiesterase 4D (PDE4D) and myocardial infarction (MI). Therefore, the aim of this research was to evaluate the association of the PDE4D gene polymorphisms with MI, and with cardiometabolic parameters in the Mexican population. Six polymorphisms (rs2910829, rs1423246, rs966221, rs4502776, rs13172481, and rs6869495) were genotyped in 1023 MI patients and 1105 healthy controls. A similar distribution of the six polymorphisms was observed in both studied groups. However, after evaluating the linkage disequilibrium, we detected a risk haplotype for MI (AGAGAA; OR = 1.148; P = 0.025). In addition, the polymorphisms were associated with the presence of some clinical and metabolic parameters (central obesity, hypertriglyceridemia, Aspartate transaminase >p75, Lipoprotein (a) >30 mg/dL, TAT >p75, fatty liver, and vitamin D <30 ng/dL) in healthy controls. The results suggest that in the Mexican population, a PDE4D haplotype is associated with increased risk of developing MI, and that PDE4D polymorphisms are independently associated with the presence of cardiometabolic parameters.
description: EXCLI Journal;Vol. 17 2018
Gauge-string duality for (non)supersymmetric deformations of N=4 Super Yang-Mills theory
Creators: name: Frolov, S. A.
name: Roiban, R.
name: Tseytlin, A. A.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a non-supersymmetric example of the AdS/CFT duality which generalizes the supersymmetric exactly marginal deformation constructed in hep-th/0502086. The string theory background we use was found in hep-th/0503201 from the AdS_5 x S5 by a combination of T-dualities and shifts of angular coordinates. It depends on three real parameters gamma_i which determine the shape of the deformed 5-sphere. The dual gauge theory has the same field content as N=4 SYM theory, but with scalar and Yukawa interactions ``deformed'' by gamma_i-dependent phases. The special case of equal deformation parameters gamma_i=gamma corresponds to the N=1 supersymmetric deformation. We compare the energies of semiclassical strings with three large angular momenta to the 1-loop anomalous dimensions of the corresponding gauge-theory scalar operators and find that they match as it was the case in the SU(3) sector of the standard AdS/CFT duality. In the supersymmetric case of equal gamma_i this extends the result of our previous work (hep-th/0503192) from the 2-spin to the 3-spin sector. This extension turns out to be quite nontrivial. To match the corresponding low-energy effective ``Landau-Lifshitz'' actions on the string theory and the gauge theory sides one is to make a special choice of the spin chain Hamiltonian representing the 1-loop gauge theory dilatation operator. This choice is adapted to low-energy approximation, i.e. it allows one to capture the right vacuum states and the macroscopic spin wave sector of states of the spin chain in the continuum coherent state effective action.
description: 43 pages, Latex; v2:Discussion of 0-modes improved in section 2, Appendix B expanded to demonstrate agreement between gauge and string theory for 0-mode fluctuations; references added; v3: Modification to the discussion on the U(1) factor in sec.4.4
Carry trade: μια εφαρμογή στο ελβετικό φράγκο
Creators: name: Αξωνίδη, Δήμητρα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Carry trade
subject: Νόμισμα χρηματοδότησης
subject: Νόμισμα στόχος
subject: Αγορά συναλλάγματος
subject: Συναλλαγματική ισοτιμία
subject: Συνθήκη ισοδυναμίας επιτοκίων
subject: Μακροοικονομικοί παράγοντες
subject: Ελβετικό φράγκο
subject: Δανεισμός σε ξένο νόμισμα
subject: Επιτόκια

description: Η κερδοφορία και η εφαρμογή του Carry Trade είναι o στόχος της παρούσας μελέτης. Αποτελεί μια επενδυτική στρατηγική, η οποία στηρίζεται στην επίτευξη κέρδους που προκύπτει από τη διαφορά επιτοκίων δύο εθνικών νομισμάτων. Στη συγκεκριμένη μελέτη, επιλέχθηκε το ελβετικό φράγκο ως νόμισμα με χαμηλό επιτόκιο για να το δανειστεί ένας επενδυτής, ο οποίος μετέπειτα θα επενδύσει το κεφάλαιο αυτό υπό τη μορφή της κατάθεσης σε ένα άλλο νόμισμα με υψηλότερο επιτόκιο που στην μελέτη μας είναι η λίρα Τουρκίας. Η διαδικασία αυτή είναι κερδοφόρα για τον επενδυτή, καθώς αποπληρώνει το δάνειο με χαμηλό κόστος λόγω του χαμηλού επιτοκίου και αναμένει να εισπράξει από την επένδυση του μεγαλύτερη απόδοση από το υψηλό επιτόκιο. Καθοριστικό ρόλο για την κερδοφορία της στρατηγικής έχουν και οι συναλλαγματικές ισοτιμίες, οι οποίες αν προβλεφθούν σωστά από τους επενδυτές, η τελική απόδοση της επένδυσης θα είναι θετική. Στην μελέτη αντλήθηκαν δεδομένα και εξετάστηκαν οι αποδόσεις τους από τα έτη 2008 έως 2020. Το συγκριτικό πλεονέκτημα αυτής είναι ότι βασίζεται στην επιλογή του συγκεκριμένου ζεύγους νομισμάτων, καθώς η πλειοψηφία της βιβλιογραφίας εξετάζει συνηθισμένα ζεύγη νομισμάτων όπως το USD/JPY, NZD/JPY και EUR/USD. Η επιλογή του ελβετικού φράγκου ως νόμισμα χρηματοδότησης έχει ιδιαίτερη σημασία λόγω της προσπάθειας της κεντρικής τραπέζης της Ελβετίας να αποτρέψει την ανατίμηση του φράγκου και της κεντρικής τραπέζης της Τουρκίας να αποτρέψει την υποτίμηση της λίρας. Μέσω αυτής της εργασίας εξετάζεται η υλοποίηση του Carry Trade μεταξύ νομισμάτων που θα δίσταζαν οι επενδυτές να επιλέξουν.
Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
Creators: name: Birch Kristensen, Emilie
name: Yakimov, Victor
name: Bjorn-Mortensen, Karen
name: Soborg, Bolette
name: Koch, Anders
name: Andersson, Mikael
name: Birch Kristensen, Kasper
name: Michelsen, Sascha Wilk
name: Skotte, Line
name: Ahrendt Bjerregaard, Anne
name: Blaszkewicz, Meinolf
name: Golka, Klaus
name: Hengstler, Jan G.
name: Feenstra, Bjarke
name: Melbye, Mads
name: Geller, Frank
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: N-acetyltransferase 2
subject: Greenland
subject: NAT2 genotype status
subject: NAT2 enzyme activity
subject: Caffeine test
subject: Isoniazid
subject: 610

description: N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test. No additional genetic variants were identified in the coding sequence of NAT2, so that genotype status in 260 study participants could be assessed by a well-established 7-SNP panel. Studying the enzyme activity by the ratio of the two caffeine metabolites AFMU and 1X in 260 participants showed a high rate of slow phenotypes with intermediate or rapid genotype. These misclassifications were mainly observed in urine samples with pH<3, a deviation from the standard protocol due to the field work character of the study, where immediate pH adjustment to pH=3.5 was not possible. We excluded these samples. For the remaining 143 individuals with pH>3, we observed a moderate level of discrepancies (19 of the 116 individuals with intermediate or rapid genotype status having a slow phenotype). Further investigation showed that drinking coffee and not tea or cola was the most important factor for high levels of both metabolites. The concordance between phenotype and genotype status with regard to slow metabolism supported the recommendation of lower isoniazid doses in individuals with slow genotype status in order to avoid liver injury, a frequent side effect. The phenotypical variation observed for individuals with intermediate or rapid genotype status warrants further research before increased dosing of isoniazid can be recommended.
description: EXCLI Journal;Vol. 17 2018
You Are What You Tweet: Profiling Users by Past Tweets to Improve Hate Speech Detection
Creators: name: Chaudhry, Prateek
name: Lease, Matthew
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Hate speech detection research has predominantly focused on purely content-based methods, without exploiting any additional context. We briefly critique pros and cons of this task formulation. We then investigate profiling users by their past utterances as an informative prior to better predict whether new utterances constitute hate speech. To evaluate this, we augment three Twitter hate speech datasets with additional timeline data, then embed this additional context into a strong baseline model. Promising results suggest merit for further investigation, though analysis is complicated by differences in annotation schemes and processes, as well as Twitter API limitations and data sharing policies.
Bioinformatics tools for basic analysis of Next Generation Sequencing data
Creators: name: Michelacci, Valeria
Publisher: name: Zenodo
Year: 2024

description: In the framework of the activities of the Inter-EURLs working group on Next Generation Sequencing, an inventory was performed during Summer 2018 on the bioinformatics tools in use for the analysis of next generation sequencing (NGS) data across the National Reference Laboratories (NRLs) networks. The aim of this action was the collection of info on the most commonly used tools, to be provided to the NRLs, and the identification of potential areas of implementation. This inventory was used as the basis for compiling a list of tools routinely used by the majority of NRLs and by EURLs for NGS data analysis. The list is routinely updated in order to keep it inclusive of novel tools developed and to delete eventual tools which are no longer maintained. This document is not to be interpreted as a list of validated tools, but only as an information on those whose use is most spread among the networks of NRLs and EURLs, along with links for an easy and fast access to such tools.

Brief description of analytical steps for basic NGS analysis

Quality check: This step aims to perform a preliminary assessment on the overall quality of the sequences produced. All the tools performing quality check accept raw sequencing files in .fastq format in input.

Trimming: This step is used to remove adaptors sequences and low quality sequences. All the tools performing trimming accept raw sequencing files in .fastq format in input.

Assembly: This step involves the identification of overlapping regions among the sequencing reads included in the sequencing file (.fastq), with the aim of producing longer sequences representative of genomic regions (contigs) compiled in an output file in .fasta format. Some assemblers are specific for long single molecule sequencing reads, such as those produced by PacBio or Oxford Nanopore platforms. Assembly pipelines can use assembly tools to optimize the assembling process. Assembly correction tools correct raw contigs generated by rapid assembly methods by comparing them with consensus sequences generated through reads alignment.

Seven genes Multi Locus Sequence Typing (MLST): This step is used to type bacterial strains according to established schemes of allelic sequences of housekeeping genes.

Virulotyping: The identification of the presence of virulence genes in the sequencing files, through comparison with precompiled databases of sequences of virulence genes.

Serotype identification: Typing of the analysed bacteria by identifying serotype-associated genes in the sequencing files, through comparison with sequences in precompiled databases.

Inference on antimicrobial resistance: This step is used to predict the antimicrobial resistance of bacterial strains from whole genome sequences, through comparison with precompiled databases of antimicrobial resistance genes and with databases of known chromosomal mutations inducing resistance to antimicrobial compounds.
Localized states in bistable pattern forming systems
Creators: name: Bortolozzo, Umberto
name: Clerc, Marcel G.
name: Falcon, Claudio
name: Residori, Stefania
name: Rojas, René
Publisher: name: arXiv
Year: 2005
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We present an unifying description of a new class of localized states, appearing as large amplitude peaks nucleating over a pattern of lower amplitude. Localized states are pinned over a lattice spontaneously generated by the system itself. We show that the phenomenon is generic and requires only the coexistence of two spatially periodic states. At the onset of the spatial bifurcation, a forced amplitude equation is derived for the critical modes, which accounts for the appearance of localized peaks
Bioinformatics tools for basic analysis of Next Generation Sequencing data
Creators: name: Michelacci, Valeria
Publisher: name: Zenodo
Year: 2020

description: In the framework of the activities of the Inter-EURLs working group on Next Generation Sequencing, an inventory was performed during Summer 2018 on the bioinformatics tools in use for the analysis of next generation sequencing (NGS) data across the National Reference Laboratories (NRLs) networks. The aim of this action was the collection of info on the most commonly used tools, to be provided to the NRLs, and the identification of potential areas of implementation. This inventory was used as the basis for compiling a list of tools routinely used by the majority of NRLs and by EURLs for NGS data analysis. The list is routinely updated in order to keep it inclusive of novel tools developed and to delete eventual tools which are no longer maintained. This document is not to be interpreted as a list of validated tools, but only as an information on those whose use is most spread among the networks of NRLs and EURLs, along with links for an easy and fast access to such tools.

Brief description of analytical steps for basic NGS analysis

Quality check: This step aims to perform a preliminary assessment on the overall quality of the sequences produced. All the tools performing quality check accept raw sequencing files in .fastq format in input.

Trimming: This step is used to remove adaptors sequences and low quality sequences. All the tools performing trimming accept raw sequencing files in .fastq format in input.

Assembly: This step involves the identification of overlapping regions among the sequencing reads included in the sequencing file (.fastq), with the aim of producing longer sequences representative of genomic regions (contigs) compiled in an output file in .fasta format. Some assemblers are specific for long single molecule sequencing reads, such as those produced by PacBio or Oxford Nanopore platforms. Assembly pipelines can use assembly tools to optimize the assembling process. Assembly correction tools correct raw contigs generated by rapid assembly methods by comparing them with consensus sequences generated through reads alignment.

Seven genes Multi Locus Sequence Typing (MLST): This step is used to type bacterial strains according to established schemes of allelic sequences of housekeeping genes.

Virulotyping: The identification of the presence of virulence genes in the sequencing files, through comparison with precompiled databases of sequences of virulence genes.

Serotype identification: Typing of the analysed bacteria by identifying serotype-associated genes in the sequencing files, through comparison with sequences in precompiled databases.

Inference on antimicrobial resistance: This step is used to predict the antimicrobial resistance of bacterial strains from whole genome sequences, through comparison with precompiled databases of antimicrobial resistance genes and with databases of known chromosomal mutations inducing resistance to antimicrobial compounds.
The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation
Creators: name: Machado, Mileni Soares
name: Rosa, Francisco D.
name: Lira, María C.
name: Urtreger, Alejandro J.
name: Rubio, María F.
name: Costas, Mónica A.
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: RAC3
subject: Cancer stem cells
subject: Mesenchymal cells
subject: TNF-malignant transformation
subject: 610

description: RAC3 is a coactivator of steroid receptors and NF-kB. It is usually overexpressed in several tumors, contributes to maintain cancer stem cells and also to induce them when is overexpressed in non-tumoral cells. In this work, we investigated whether the inflammatory cytokine TNF may contribute to the transforming effects of RAC3 overexpression in the non-tumoral HEK293 cell line. The study model included the HEK293 tumoral transformed cell line constitutively overexpressing RAC3 by stable transfection and control non-tumoral cells transfected with an empty vector. The HeLa and T47D tumoral cells that naturally overexpress RAC3 were used as positive control. We found that TNF potentiated RAC3-induced mesenchymal transition, involving an increased E-Cadherin downregulation, Vimentin and SNAIL upregulation and enhanced migratory behavior. Moreover, concerning the molecular mechanisms by which TNF potentiates the RAC3 transforming action, they involve the IKK activation, which in addition induced the -Catenin transactivation. Our results demonstrate that although RAC3 overexpression could be a signal strong enough to induce cancer stem cells, the inflammatory microenvironment may be playing a key role contributing to the migratory and invasive phenotype required for metastasis and cancer persistence.
description: EXCLI Journal;Vol. 17 2018
The Onsager Algebra Symmetry of $τ^{(j)}$-matrices in the Superintegrable Chiral Potts Model
Creators: name: Roan, Shi-shyr
Publisher: name: arXiv
Year: 2005
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Geometry (math.AG)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We demonstrate that the $τ^{(j)}$-matrices in the superintegrable chiral Potts model possess the Onsager algebra symmetry for their degenerate eigenvalues. The Fabricius-McCoy comparison of functional relations of the eight-vertex model for roots of unity and the superintegrable chiral Potts model has been carefully analyzed by identifying equivalent terms in the corresponding equations, by which we extract the conjectured relation of $Q$-operators and all fusion matrices in the eight-vertex model corresponding to the $T\hat{T}$-relation in the chiral Potts model.
description: Latex 21 pages; Typos added, References updated
Perspective on gravitational self-force analyses
Creators: name: Detweiler, Steven
Publisher: name: arXiv
Year: 2005
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A point particle of mass $μ$ moving on a geodesic creates a perturbation $h_{ab}$, of the spacetime metric $g_{ab}$, that diverges at the particle. Simple expressions are given for the singular $μ/r$ part of $h_{ab}$ and its distortion caused by the spacetime. This singular part $h^\SS_{ab}$ is described in different coordinate systems and in different gauges. Subtracting $h^\SS_{ab}$ from $h_{ab}$ leaves a regular remainder $h^\R_{ab}$. The self-force on the particle from its own gravitational field adjusts the world line at $\Or(μ)$ to be a geodesic of $g_{ab}+h^\R_{ab}$; this adjustment includes all of the effects of radiation reaction. For the case that the particle is a small non-rotating black hole, we give a uniformly valid approximation to a solution of the Einstein equations, with a remainder of $\Or(μ^2)$ as $μ\to0$. An example presents the actual steps involved in a self-force calculation. Gauge freedom introduces ambiguity in perturbation analysis. However, physically interesting problems avoid this ambiguity.
description: 40 pages, to appear in a special issue of CQG on radiation reaction, contains additional references, improved notation for tensor harmonics
Γενετικά τροποποιημένα τρόφιμα και η επίδραση τους στον άνθρωπο
Creators: name: Ασιθιανάκης, Αναστάσιος-Πέτρος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: ΕΑΑΤ
subject: ΠΟΕ
subject: GMOs
subject: ΓΤΟ
subject: ISAAA
subject: ΜΚΟ
subject: FDA
subject: EE
subject: ΓΓΤ
subject: ΠΟΥ
subject: ΓΤΦ

description: Στην παρούσα εργασία επιχειρείται η διερεύνηση του άκρως αμφιλεγόμενου ζητήματος των γενετικά τροποποιημένων οργανισμών (ΓΤΟ). Γίνεται εκτενής αναφορά στα οφέλη και τις επιπτώσεις από τη χρήση και κατανάλωση τέτοιου είδους τροφίμων, καθώς και στα προβλήματα που μπορεί να προκαλέσουν. Επίσης, πραγματοποιείται αποτύπωση και ανάλυση και του νομικού πλαισίου που αφορά στους ΓΤΟ, τόσο στην Ελλάδα και την Ευρωπαϊκή Ένωση. Ήδη αρκετά χρόνια πριν, για την επίλυση των διαρκώς αυξανόμενων προβλημάτων στην διατροφή των ανθρώπων, ξεκίνησαν να αναπτύσσονται στην Αμερική τεχνικές γενετικής τροποποίησης με αποτέλεσμα, πλέον, μεγάλο ποσοστό των τροφίμων που καταναλώνουμε, να είναι γενετικά τροποποιημένα τρόφιμα (ΓΤΤ) ή, άλλως, «μεταλλαγμένα». Η τεράστια βιομηχανία γενετικά μεταλλαγμένων τροφίμων παγκοσμίως ισχυρίζεται ότι τα γενετικά τροποποιημένα τρόφιμα είναι ασφαλή. Όμως δεν είναι καθόλου λίγοι και εκείνοι που διαφωνούν και υποστηρίζουν ότι δεν έχουν γίνει οι αναγκαίες πειραματικές μελέτες για τις τυχόν μακροχρόνιες επιδράσεις τους στη υγεία. Για την έρευνα που ακολουθεί, χρειάστηκε η συλλογή αρκετού υλικού, το οποίο προέρχεται κυρίως από επιστημονικές δημοσιεύσεις σε διεθνή περιοδικά, από την ιστοσελίδα της Ευρωπαϊκής Ένωσης και από τον Παγκόσμιο Οργανισμό Εμπορίου (ΠΟΕ). Η διάρθρωση της μελέτης έχει ως εξής: Αρχικά, γίνεται μια αναφορά σχετικά με το πότε ξεκίνησε η χρήση ΓΤΤ και πως έφτασε στην Ευρώπη και την Ελλάδα. Στη συνέχεια ακολουθούν στοιχεία σχετικά με τη νομοθεσία που διέπει τα ΓΤΤ στις ΗΠΑ, στην Ευρωπαϊκή Ένωση (ΕΕ) και στην Ελλάδα. Περαιτέρω, πραγματοποιείται μία σύγκριση των ισχυόντων νομοθεσιών στις εν λόγω έννομες τάξεις ενώ διερευνώνται και οι λόγοι της διαφορετικής αντιμετώπισης των ΓΤΤ στις ΗΠΑ και την ΕΕ. Τέλος, αναλύονται τα πλεονεκτήματα και τα μειονεκτήματα της χρήσης τέτοιου είδους τροφίμων. Έμφαση δίδεται στα προβλήματα που ενδέχεται να προκαλέσουν τα ΓΤΤ στον ανθρώπινο οργανισμό.
Bioinformatics tools for basic analysis of Next Generation Sequencing data
Creators: name: Michelacci, Valeria
Publisher: name: Zenodo
Year: 2022

description: In the framework of the activities of the Inter-EURLs working group on Next Generation Sequencing, an inventory was performed during Summer 2018 on the bioinformatics tools in use for the analysis of next generation sequencing (NGS) data across the National Reference Laboratories (NRLs) networks. The aim of this action was the collection of info on the most commonly used tools, to be provided to the NRLs, and the identification of potential areas of implementation. This inventory was used as the basis for compiling a list of tools routinely used by the majority of NRLs and by EURLs for NGS data analysis. The list is routinely updated in order to keep it inclusive of novel tools developed and to delete eventual tools which are no longer maintained. This document is not to be interpreted as a list of validated tools, but only as an information on those whose use is most spread among the networks of NRLs and EURLs, along with links for an easy and fast access to such tools.

Brief description of analytical steps for basic NGS analysis

Quality check: This step aims to perform a preliminary assessment on the overall quality of the sequences produced. All the tools performing quality check accept raw sequencing files in .fastq format in input.

Trimming: This step is used to remove adaptors sequences and low quality sequences. All the tools performing trimming accept raw sequencing files in .fastq format in input.

Assembly: This step involves the identification of overlapping regions among the sequencing reads included in the sequencing file (.fastq), with the aim of producing longer sequences representative of genomic regions (contigs) compiled in an output file in .fasta format. Some assemblers are specific for long single molecule sequencing reads, such as those produced by PacBio or Oxford Nanopore platforms. Assembly pipelines can use assembly tools to optimize the assembling process. Assembly correction tools correct raw contigs generated by rapid assembly methods by comparing them with consensus sequences generated through reads alignment.

Seven genes Multi Locus Sequence Typing (MLST): This step is used to type bacterial strains according to established schemes of allelic sequences of housekeeping genes.

Virulotyping: The identification of the presence of virulence genes in the sequencing files, through comparison with precompiled databases of sequences of virulence genes.

Serotype identification: Typing of the analysed bacteria by identifying serotype-associated genes in the sequencing files, through comparison with sequences in precompiled databases.

Inference on antimicrobial resistance: This step is used to predict the antimicrobial resistance of bacterial strains from whole genome sequences, through comparison with precompiled databases of antimicrobial resistance genes and with databases of known chromosomal mutations inducing resistance to antimicrobial compounds.
Development of competitive lateral flow immunoassay coupled with silver enhancement for simple and sensitive salivary cortisol detection
Creators: name: Apilux, Amara
name: Rengpipat, Sirirat
name: Suwanjang, Wilasinee
name: Chailapakul, Orawon
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Cortisol
subject: Lateral flow immunoassay
subject: Silver enhancement
subject: Gold nanoparticles
subject: 610

description: Cortisol is known as a stress biomarker. The measurement of cortisol levels is an early warning indicator for health conditions and diagnosis of stress-related diseases. Herein, a lateral flow immunoassay using a gold nanoparticle label with a silver enhancement system was developed for the simple, sensitive and rapid detection of cortisol. The developed assay was based on a competitive platform of which cortisol-BSA conjugate was immobilized at the test zone to compete with an analyte. The quantitative analysis was performed using gold nanoparticles (AuNPs) as signal labeling. Sequentially, the silver enhancement solution was applied in order to enhance the sensitivity of the assay with the results easily seen by the naked eye. Using this system, the limit of detection (LOD) was found to be 0.5 ng/mL with a 3.6 fold more sensitive detection than without the enhancement system (LOD = 1.8 ng/mL). The salivary cortisol analysis was in the range of 0.5-150 ng/mL (R2 = 0.9984), which is in the clinical acceptable range. For the semi-quantitative analysis, the intensity color of the results was analyzed using an image processing program. The proposed method was successfully applied to detect cortisol in saliva. In addition, the results from our method also complied with the ones of those obtained by using the commercial enzyme-linked immunosorbent assay (ELISA). This developed assay offers great promise for a non-invasive screening test of salivary cortisol.
description: EXCLI Journal;Vol. 17 2018