Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
Creators: name: Strakova, Andrea
name: Nicholls, Thomas J.
name: Baez-Ortega, Adrian
name: Ní Leathlobhair, Máire
name: Sampson, Alexander T.
name: Hughes, Katherine
name: Bolton, Isobelle A. G.
name: Gori, Kevin
name: Wang, Jinhong
name: Airikkala-Otter, Ilona
name: Allen, Janice L.
name: Allum, Karen M.
name: Arnold, Clara L.
name: Bansse-Issa, Leontine
name: Bhutia, Thinlay N.
name: Bisson, Jocelyn L.
name: Blank, Kelli
name: Briceño, Cristóbal
name: Castillo Domracheva, Artemio
name: Corrigan, Anne M.
name: Cran, Hugh R.
name: Crawford, Jane T.
name: Cutter, Stephen M.
name: Davis, Eric
name: De Castro, Karina F.
name: De Nardi, Andrigo B.
name: De Vos, Anna P.
name: Delgadillo Keenan, Laura
name: Donelan, Edward M.
name: Espinoza Huerta, Adela R.
name: Faramade, Ibikunle A.
name: Fazil, Mohammed
name: Fotopoulou, Eleni
name: Fruean, Skye N.
name: Gallardo-Arrieta, Fanny
name: Glebova, Olga
name: Gouletsou, Pagona G.
name: Häfelin Manrique, Rodrigo F.
name: Henriques, Joaquim J. G. P.
name: Horta, Rodrigo S.
name: Ignatenko, Natalia
name: Kane, Yaghouba
name: King, Cathy
name: Koenig, Debbie
name: Krupa, Ada
name: Kruzeniski, Steven J.
name: Lanza-Perea, Marta
name: Lazyan, Mihran
name: Lopez Quintana, Adriana M.
name: Losfelt, Thibault
name: Marino, Gabriele
name: Martínez Castañeda, Simón
name: Martínez-López, Mayra F.
name: Masuruli, Bedan M.
name: Meyer, Michael
name: Migneco, Edward J.
name: Nakanwagi, Berna
name: Neal, Karter B.
name: Neunzig, Winifred
name: Nixon, Sally J.
name: Ortega-Pacheco, Antonio
name: Pedraza-Ordoñez, Francisco
name: Peleteiro, Maria C.
name: Polak, Katherine
name: Pye, Ruth J.
name: Ramirez-Ante, Juan C.
name: Reece, John F.
name: Rojas Gutierrez, Jose
name: Sadia, Haleema
name: Schmeling, Sheila K.
name: Shamanova, Olga
name: Sherlock, Alan G.
name: Steenland-Smit, Audrey E.
name: Svitich, Alla
name: Tapia Martínez, Lester J.
name: Thoya Ngoka, Ismail
name: Torres, Cristian G.
name: Tudor, Elizabeth M.
name: Van Der Wel, Mirjam G.
name: Vițălaru, Bogdan A.
name: Vural, Sevil A.
name: Walkinton, Oliver
name: Wehrle-Martinez, Alvaro S.
name: Widdowson, Sophie A. E.
name: Zvarich, Irina
name: Chinnery, Patrick F.
name: Falkenberg, Maria
name: Gustafsson, Claes M.
name: Murchison, Elizabeth P.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/67
/631/181
/631/208
/45
/45/23
/45/91
article

description: Abstract: Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.