cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bittium Gray 1847
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Cerithiidae
Bittium

description: Bittium an nov. sp.?
Plate 1 L 1 -L 2, M 1 -M 2
Santa Maria material examined. Maximum height 4.5 mm, width 1.8 mm. DBUA-F 488-2 (29), Ponta do Castelo, Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Description. Shell small, turriculate, with tall, slender spire, apical angle about 33°. Protoconch not preserved. Teleoconch of nine weakly convex whorls, initially slightly cyrtoconoid in profile, separated by a narrow, moderately impressed, undulating suture. Sculpture of broad rounded, slightly opisthocline to orthocline ribs, about seven on penultimate whorl, extending between suture and weakly crenulating abapical suture. Last two whorls with one or two varices per whorl. Spiral sculpture weak, on early whorls three broad flattened cords separated by narrow grooves. Spiral sculpture weakens on fourth whorl, subobsolete on last three whorls. Axial sculpture predominant, without tubercles produced at intersections. Last whorl convex, moderately constricted at base, bearing a spiral cord at the level of the insertion of the outer lip, a peribasal cord of similar strength, and three weaker basal cords. Aperture ovate, features obscured by matrix.
Discussion. Bittium an nov. sp. is clearly similar to B. miradouroense nov. sp. but differs in having a wider apical angle (33° vs. 23°) and fewer axial ribs (7 vs. 12). The character of the spiral sculpture seems to be similar, slightly stronger on early whorls and both species have two spiral cords delimiting the base. However, comparison is hampered by the form of preservation: the specimen of Bittium an nov. sp. is somewhat decorticated, whereas the fossils of B. miradouroense are calcitic pseudomorphs. Nevertheless, the wider apical angle and the small number of ribs seem to be constant characters separating the two. As discussed under B. miradouroense, the shells of these two species are not particularly similar to any other Neogene or extant European species.
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (this paper).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on pages 32-33, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Structural insights into the human D1 and D2 dopamine receptor signaling complexes
Creators: name: Mao, C
name: Shen, D.-D
name: Xu, H.E
name: Zhang, Y
name: Liu, Y.-F
name: Cheng, X
name: Roth, B.L
name: Xu, P
name: Liu, H
name: Zhuang, Y
name: Zhou, X.E
name: Guo, J
name: Xu, T
name: Wang, L
name: Jiang, Y
name: Huang, X.-P
name: Huang, S
name: Melcher, K
name: Krumm, B
name: Wang, Y
name: Jiang, H
name: Zhang, C
Publisher: name: Elsevier B.V.
Year: 2021

description: The D1- and D2-dopamine receptors (D1R and D2R), which signal through Gs and Gi, respectively, represent the principal stimulatory and inhibitory dopamine receptors in the central nervous system. D1R and D2R also represent the main therapeutic targets for Parkinson's disease, schizophrenia, and many other neuropsychiatric disorders, and insight into their signaling is essential for understanding both therapeutic and side effects of dopaminergic drugs. Here, we report four cryoelectron microscopy (cryo-EM) structures of D1R-Gs and D2R-Gi signaling complexes with selective and non-selective dopamine agonists, including two currently used anti-Parkinson's disease drugs, apomorphine and bromocriptine. These structures, together with mutagenesis studies, reveal the conserved binding mode of dopamine agonists, the unique pocket topology underlying ligand selectivity, the conformational changes in receptor activation, and potential structural determinants for G protein-coupling selectivity. These results provide both a molecular understanding of dopamine signaling and multiple structural templates for drug design targeting the dopaminergic system. © 2021 Elsevier Inc.Near-atomic resolution structures of activated D1R-Gs and D2R-Gi signaling complexes, together with multiple functional studies, reveal the conserved catechol agonist binding mode in D1R and the structural basis that underlies D1R and D2R ligand selectivity and G protein-coupling specificity.
Is sexual dimorphism in morphometric variables of the proximal femur moderated by age in adulthood? A cross-sectional study in Ghana
Creators: name: Abdulai, Abdul-Rafik
name: Banyeh, Moses
name: Osabutey, Emmanuel Kweku
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Science Policy

description: Ageing may impact proximal femoral morphometry in both males and females. However, it is not clear whether the observed sexual dimorphism is attributable to an ageing effect in the post-pubertal period. The potential effect of ageing on sexual dimorphism in the proximal femur is most significantly relevant for forensic and osteoarchaeological research. The study was cross-sectional and comprised 123 participants (females = 72 and males = 51), who were recorded between January 2017 and June 2018 at the Korle-Bu Teaching Hospital. The study participants were aged between 31 and 79 years. The femoral head diameter, the femoral neck diameter, the femoral neck-shaft angle, and the femoral hip axis length were measured from the right side by radiographic technique and following standard osteometry methods. The femoral head-neck ratio was then calculated. All measurements were taken twice and then averaged. The (mean ± SD) femoral head diameter was higher in males (5.1 ± 0.56 cm) than in females (4.8 ± 0.51 cm) with a moderate effect size (p = 0.023, Hedge’s g = 0.56). Similarly, the femoral neck diameter was higher in males (4.0 ± 0.52 cm) than in females (3.8 ± 0.48 cm) with a small effect size (p = 0.025, Hedge’s g = 0.40). The femoral head axis length increased by 0.03 cm annually in males. The observed sexual dimorphism in the femoral head and neck diameters could not, however, be attributable to the ageing effect. Ageing may not have an impact on sexual dimorphism in the femoral head and neck diameters among persons older than 30 years in the Ghanaian population.
Tenagodus Sacchetti, Landau & Ávila, 2023, s. str.
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Siliquariidae
Tenagodus

description: Subgenus Tenagodus s. str.
Type species. Serpula anguina Linnaeus, 1758 (Guettard 1770: 128), by subsequent designation (Sacco 1896b). Present-day, Indian Ocean.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 34, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Zercon C.L. Koch 1836
Creators: name: Urhan, Raşit
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Blattisociidae
Zercon

description: Genus: Zercon C.L. Koch, 1836
Type species: Zercon triangularis C.L. Koch, 1836
description: Published as part of Urhan, Raşit, 2007, A new species of the genus Zercon (Acari, Zerconidae) from Turkey, pp. 47-54 in Zootaxa 1463 on page 48, DOI: 10.5281/zenodo.176475
The effect of bait age and season on trap catch of blow fly species composition (Diptera: Calliphoridae) in a suburban habitat
Creators: name: Constant, Vanessa
name: Beresford, David V.
name: Vezsenyi, Kathryn A.
name: Fleming, Kaitlyn J.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: We document the blow fly species caught at two baited traps from May to July 2021 in a suburban region of southern Ontario. Baited traps were deployed in a residential area of St Catharines, Ontario, which captured blow flies from 7 species, the most abundant being Lucilia sericata (Meigen, 1826) (878) and Phormia regina Meigen, 1826 (397). Traps were baited with chicken drumsticks of various ages. We found that trap catch increased from late spring to summer, but there was no effect of bait age on the number of flies caught.
Structural insights into the human niacin receptor HCA2-Gi signalling complex
Creators: name: Liu Z.-J
name: Stevens R.C
name: Kenakin T
name: Wang Q
name: Han G.W
name: Tong J
name: Roth B.L
name: Wang J
name: Kang H.J
name: DiBerto J.F
name: Gao R
name: Qu L
name: Peng W
name: Rao Z
name: Wu Y
name: Yang Y
name: Zhang X.C
name: Pileski R
name: Zhao S
name: Li X
name: Wu L
Publisher: name: Nature Research
Year: 2023

description: The hydroxycarboxylic acid receptor 2 (HCA2) agonist niacin has been used as treatment for dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated individuals. Extensive efforts have been made to identify HCA2 targeting lipid lowering agents with fewer adverse effects, despite little being known about the molecular basis of HCA2 mediated signalling. Here, we report the cryo-electron microscopy structure of the HCA2-Gi signalling complex with the potent agonist MK-6892, along with crystal structures of HCA2 in inactive state. These structures, together with comprehensive pharmacological analysis, reveal the ligand binding mode and activation and signalling mechanisms of HCA2. This study elucidates the structural determinants essential for HCA2 mediated signalling and provides insights into ligand discovery for HCA2 and related receptors.
Structural optimizations and bioevaluation of N-H aporphine analogues as Gq-biased and selective serotonin 5-HT2C receptor agonists
Creators: name: Chen, J
name: Tian, S
name: Shui, W
name: Yang, H
name: Mao, Q
name: Ye, N
name: Huang, X.-P
name: Zhen, X.-C
name: Xin, Y
name: Qin, W
name: Zhang, B
Publisher: name: Academic Press Inc.
Year: 2022

description: The concept of subtype selectivity and functional bias has recently reshaped current GPCR drug discovery for G protein-coupled receptors. A series of new N-H aporphines with A-ring modifications have been synthesized, and their efficacy on 5-HT2 receptor activation was evaluated. SAR analysis led to the discovery of several more potent and selective 5-HT2C receptor agonists (e.g., 11b and 11f) with low nanomolar activity. Molecular docking analysis of this series of aporphines was in accordance with our SAR results. The functional selectivity of specific compounds was tested via both Gq-mediated calcium flux and β-arrestin recruitment assays, which revealed that these compounds exhibited no β-arrestin recruitment activity. Further ADMET study combined with behavioral assessment using a methamphetamine-induced hyperactivity model identified compound 11b and 11f possessing promising drug-like profiles and having antipsychotic potential. These agonists with an exclusive bias toward Gq signaling may serve as valuable pharmacological probes to facilitate the elucidation of therapeutically relevant 5-HT2C signaling pathways and the development of alternative antipsychotic medications.
Panau variegatum
Creators: name: Yakovlev, R. V.
name: Hulsbosch, R.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Cossidae
Panau
Panau variegatum

description: Panau variegatum (Roepke, 1957)
(Figs 1–2)
Xyleutes variegata Roepke, 1957: 28–29, pl. 2, fig. 3, pl. 8, figs 4–4a (“ Xyleutes variegata spec. nov. ”).
Panau variegata: Schoorl, 1990: 166; Yakovlev, 2011: 72.
Type locality. “Tonsea Lama, North Celebes” [Indonesia, North Sulawesi, Minahasa Regency, 1°19′26.2″N 124°57′17.8″E].
Type material examined. Holotype. Male, with labels: “N. Celebes. / M. Tonsea Lama / 18 Maart 1920 / Mus. Leiden.”, “Typus / Holo / Roepke”, “Museum Leiden / verzameling / W K J Roepke”, “ Panau variegata ” (NBCL).
Description of male genitalia. Uncus long, with acute beak-like apex and deep longitudinal notch on lower surface. Gnathos arms thin, short, belt-like, not fused. Valve long, leaf-like, poorly narrowing to apex; outer margin semicircular; costal margin slightly curved, almost smooth; abdominal margin with deep semicircular notch in proximal third. Juxta saddle-like, robust, with a pair of long leaf-like lateral processes. Saccus small, conical, apically semicircular. Phallus thick, with longitudinal folding along all surface; lateral surface of vesica with large finger-shaped cornutus being slightly smaller than phallus.
Comparison. Externally, the species is close to P. tanimbari sp. nov., from which it differs in the more expressed light brown pattern on the forewing, uniform thickness of the uncus and more expressed notch on the abdominal margin of the valve in the proximal third.
Remarks. Female is unknown. One of the paratypes, kept in NHMUK, was collected in New Guinea without indicating the exact location on the label (Roepke, 1957: 29). Its species affiliation will be checked later.
Distribution. Indonesia (Sulawesi Island),? New Guinea.
Flight period. The type series was collected from March to July.
description: Published as part of Yakovlev, R. V. & Hulsbosch, R., 2023, Two new species of the genus Panau (Lepidoptera: Cossidae) from the Philippines and Indonesia, with the redescription of Panau variegatum, pp. 3-7 in Zoosystematica Rossica (Zoosyst. Rossica) (Zoosyst. Rossica) 32 (1) on page 4, DOI: 10.31610/zsr/2023.32.1.3, http://zenodo.org/record/10124265
Epitonium Roding 1798
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Architaenioglossa
Epitoniidae
Epitonium

description: Genus Epitonium Röding, 1798
Type species. Turbo scalaris Linnaeus, 1758 (R̂ding 1798: 91), by subsequent designation (Suter 1913). Present-day, Indo-Pacific.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 36, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Epitonium undetermined
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Architaenioglossa
Epitoniidae
Epitonium
Epitonium undetermined

description: Epitonium sp.
Plate 2 C
Santa Maria material examined. Maximum height 4.0 mm, width 2.8 mm. DBUA-F 931-1 (1), Pedra-que-pica, Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Discussion. A small fragment of Epitonium sp. records its presence in the Azorean assemblages, but it is too poor for further determination.
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (this paper).
Genus Janthina Röding, 1798
Type species. Helix janthina Linnaeus, 1758 (R̂ding 1798: 75), by tautonymy. Present-day, cosmopolitan.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 36, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
CHANG CHOLG'U IJROCHILIGINING TA'LIM JARAYONIDAGI MEZONLARI
Creators: name: Abdunazarova Diyora
name: Axadjon Mamadaliyev
Publisher: name: Academic Scientific Research Group
Year: 2024

description: O‘zbekiston musiqa san‘atining hozirgi rivojlanish bosqichida cholg‘u ijrochiligi muhim o‘rin tutadi. Shu sababli musiqa ta‘limi jarayonida bo‘lajak sozandalarning ijrochilik mahorati talab darajasida shakllantirish dolzarb vazifalardan hisoblanadi. Maqolada san‘atning naqadar nafisligi, mashaqqatli kasb ekanligi, uning mashaqqati va yuksalishi haqida so‘z boradi.
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Creators: name: Panova O
name: Nichols D.E
name: Shoichet B.K
name: Lyu J
name: Skiniotis G
name: Che T
name: Roth B.L
name: DiBerto J.F
name: Wacker D
name: Robertson M.J
name: Kim K
name: Krumm B.E
name: Seven A.B
Publisher: name: Cell Press
Year: 2020

description: Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin being considered as a therapeutic for many neuropsychiatric disorders including depression, anxiety, and substance abuse. How psychedelics mediate their actions—both therapeutic and hallucinogenic—are not understood, although activation of the 5-HT2A serotonin receptor (HTR2A) is key. To gain molecular insights into psychedelic actions, we determined the active-state structure of HTR2A bound to 25-CN-NBOH—a prototypical hallucinogen—in complex with an engineered Gαq heterotrimer by cryoelectron microscopy (cryo-EM). We also obtained the X-ray crystal structures of HTR2A complexed with the arrestin-biased ligand LSD or the inverse agonist methiothepin. Comparisons of these structures reveal determinants responsible for HTR2A-Gαq protein interactions as well as the conformational rearrangements involved in active-state transitions. Given the potential therapeutic actions of hallucinogens, these findings could accelerate the discovery of more selective drugs for the treatment of a variety of neuropsychiatric disorders. © 2020 Elsevier Inc.; Roth et al. reveal structurally how psychedelics, including LSD, psilocin, mescaline, and various N-BOH analogs, mediate their therapeutic and hallucinogenic effects by binding to and activating their molecular target, the serotonin (5-HT) 2A receptor coupled with G-protein Gαq.
Janthina krejcii Beu 2017
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Stylommatophora
Epitoniidae
Janthina
Janthina krejcii

description: Janthina krejcii Beu, 2017
Plate 2 D 1 -D 3
Janthina typica (Bronn) — Krejci-Graf et al. 1958: 336, pl. 3, fig. 6, pl. 4, fig. 11 [non Janthina typica (Bronn, 1861)].
* Janthina krejcii Beu 2017: 173, figs. 26A-N.
Type material. Holotype SMF10135a, height 23.0 mm, diameter 30.8 mm with two paratypes SMF10135b–c, labelled “ Azoren, Santa Maria, Wegknick [road bend] bei Praia, K. Krejci-Graf,” 23 April 1955, in SMF. The type locality is the upper, seaward-directed hairpin bend on the road descending from Almagreira to the beach at Praia, Santa Maria Island, illustrated by Krejci-Graf et al. (1958: fig. 4) (a lower, landward-directed hairpin bend is in the underlying volcanic rocks). Ten paratypes GNSWM 18973, Macela viewpoint.
Other material. No further specimens known.
Description. Teleoconch moderately large, short and wide (D/H 1.2–1.35), spire very low to almost flat, whorls evenly convex; completely covered with fine, straight, acline axial ridges, but without obvious spiral sculpture. Outer lip straight, acline; sinus small, moderately deep, semicircular to weakly V-shaped, situated at base of lip. For fuller description, see Beu (2017: 173).
Discussion. Janthina krejcii Beu, 2017 resembles J. typica (Bronn, 1861) and J. chavani (Ludbrook, 1978) in its uniform sculpture of fine, closely spaced, straight axial ridges over the entire teleoconch and in its semicircular to shallowly V-shaped outer-lip sinus situated at the base of the lip. However, it differs from them both in its consistently very low to almost flat spire, so that width is significantly greater than height in all specimens, and in its complete lack of obvious spiral sculpture (Beu 2017: 173). For further discussion, see under J. typica (hoc opus) and Beu (2017: 173).
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (Beu 2017).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 36, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
The assessment of childhood maltreatment and its associations with affective symptoms in adulthood: Results of the German National Cohort (NAKO)
Creators: name: Klinger-König, Johanna
name: Streit, Fabian
name: Erhardt, Angelika
name: Kleineidam, Luca
name: Schmiedek, Florian
name: Schmidt, Börge
name: Investigators, Nako
name: Wagner, Michael
name: Deckert, Jürgen
name: Rietschel, Marcella
name: Berger, Klaus
name: Grabe, Hans J.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: Childhood maltreatment affects 20–30% of the German population and is an important risk factor for physical and mental diseases in adult life. This study reports first results of the distribution of childhood maltreatment in the population-based mega cohort German National Cohort (NAKO) and estimates associations with affective symptoms in adulthood. The Childhood Trauma Screener (CTS), a short version of the Childhood Trauma Questionnaire, was used in 83,995 adults (age: 20–72 years; 47.3% men) of NAKO. The five-item CTS assesses the severity of three types of childhood abuse and two types of childhood neglect. Overall, 21,131 participants (27.5%) reported at least one type of childhood maltreatment; 14,017 participants (18.3%) reported exactly one type and 250 participants (0.3%) reported all five types of childhood maltreatment. Small differences regarding age (mean absolute deviation around the mean (MAD)=0.47), sex (MAD = 0.07) and education (MAD = 0.82) were observed. The severity of childhood maltreatment was associated with more severe symptoms of depression (β = 0.23), anxiety (β = 0.21) and perceived stress (β = 0.23) in adulthood, validated particularly for emotional abuse and emotional neglect. The distribution of childhood maltreatment in NAKO is similar to previous reports. Additionally, our results suggest differential associations with psychopathological symptoms for the five types of childhood maltreatment.
Schoengastiella (Jadiniella) hypoderma Vercammen-Grandjean 1956
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Walchiidae
Schoengastiella
Schoengastiella hypoderma

description: Schoengasitella (Jadiniella) hypoderma Vercammen-Grandjean, 1956c:
AFR
Schoengastiella hypoderma, Stekolnikov 2018b
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
THE ROLE OF IMAGINATION IN CHILDREN'S LITERATURE
Creators: name: Umaraliyeva, Madina
name: Shermamatov, S.
Publisher: name: Zenodo
Year: 2024

description: Imagination plays a vital role in children's literature, helping young readers explore new worlds, ideas, and experiences. Through imaginative narratives, children are introduced to complex concepts such as empathy, identity, and moral reasoning. This article examines the significance of imagination in children's stories, highlighting its psychological, cognitive, and social benefits. It explores how literature nurtures creativity, emotional intelligence, and problem-solving skills, contributing to a child's cognitive development and emotional well-being. Furthermore, the paper reviews key theories and examples in the field of children's literature.
Panau tanimbari Yakovlev & Hulsbosch 2023, sp.nov.
Creators: name: Yakovlev, R. V.
name: Hulsbosch, R.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Cossidae
Panau
Panau tanimbari

description: Panau tanimbari sp.nov.
(Figs 5−6)
Holotype. Male, with labels: “Tenimber / Sunda Ins.”, “Stauding. u. Bang-Haas / Dresden, Ankauf 1961”, “Dresden / Coss 2”, “HOLOTYPUS / Panau tanimbari / Yakovlev & Hulsbosch, 2023 / Yakovlev & Hulsbosch des., 2022” (SNSD).
Paratype. 1 male, with same locality and date as for holotype (SNSD).
Description. Male. Length of forewing: 24 mm in holotype, 23 mm in paratype. Antenna short, about one-third of forewing in length; basal half of antenna bipectinate, with long setae (2.5−3.0 times as long as diameter of antenna stem); distal half of antenna unipectinate, with very short setae. Tegulae and patagia densely covered with light grey scales. Abdomen basally light grey, in other parts light brown, with light grey spots on dorsal surface. Forewing grey-brown; long light brown stroke from wing base to postdiscal area between veins of cubital stem; light brown stroke in medial area postdiscally; thin undulated longitudinal lines between veins of medial and cubital stems postdiscally; poorly expressed grey reticulated pattern submarginally; fringe dark at veins, light between veins. Hind wing grey-brown, without pattern; fringe dark at veins, light between veins.
Male genitalia. Uncus long, with acute beak-like apex, apical third noticeably thickened and deep longitudinal notch on lower surface. Gnathos arms thin, long, belt-like, not fused. Valve long, leaf-like, slightly curved along length, slightly narrowing to apex; outer margin semicircular; costal margin slightly curved; abdominal margin with small notch in proximal third. Juxta saddle-like, robust, with a pair of long leaf-like lateral processes. Saccus small, conical, apically acute. Phallus thick, with longitudinal folding on all surface; lateral surface of vesica with large finger-shaped cornutus almost equal to phallus in length.
Female unknown.
Comparison. Externally, P. tanimbari sp. nov. is close to P. variegatum, from which it differs in the less expressed light brown pattern on the forewing, thick distal third of the uncus, and less expressed notch on the abdominal margin of the valve in the proximal third.
Etymology. The new species is named after the region where it was collected, the Tanimbar Island.
Distribution. Indonesia: Tanimbar Island.
description: Published as part of Yakovlev, R. V. & Hulsbosch, R., 2023, Two new species of the genus Panau (Lepidoptera: Cossidae) from the Philippines and Indonesia, with the redescription of Panau variegatum, pp. 3-7 in Zoosystematica Rossica (Zoosyst. Rossica) (Zoosyst. Rossica) 32 (1) on page 6, DOI: 10.31610/zsr/2023.32.1.3, http://zenodo.org/record/10124265
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry
Creators: name: Shang J
name: Baric R
name: Liu C
name: Wan Y
name: Auerbach A
name: Gully K
name: Li F
name: Yount B
name: Peng G
name: Yang Y
Publisher: name: Public Library of Science
Year: 2020

description: Coronaviruses recognize a variety of receptors using different domains of their envelope-anchored spike protein. How these diverse receptor recognition patterns affect viral entry is unknown. Mouse hepatitis coronavirus (MHV) is the only known coronavirus that uses the N-terminal domain (NTD) of its spike to recognize a protein receptor, CEACAM1a. Here we determined the cryo-EM structure of MHV spike complexed with mouse CEACAM1a. The trimeric spike contains three receptor-binding S1 heads sitting on top of a trimeric membrane-fusion S2 stalk. Three receptor molecules bind to the sides of the spike trimer, where three NTDs are located. Receptor binding induces structural changes in the spike, weakening the interactions between S1 and S2. Using protease sensitivity and negative-stain EM analyses, we further showed that after protease treatment of the spike, receptor binding facilitated the dissociation of S1 from S2, allowing S2 to transition from pre-fusion to post-fusion conformation. Together these results reveal a new role of receptor binding in MHV entry: in addition to its well-characterized role in viral attachment to host cells, receptor binding also induces the conformational change of the spike and hence the fusion of viral and host membranes. Our study provides new mechanistic insight into coronavirus entry and highlights the diverse entry mechanisms used by different viruses.
The assessment of childhood maltreatment and its associations with affective symptoms in adulthood: Results of the German National Cohort (NAKO)
Creators: name: Klinger-König, Johanna
name: Streit, Fabian
name: Erhardt, Angelika
name: Kleineidam, Luca
name: Schmiedek, Florian
name: Schmidt, Börge
name: Wagner, Michael
name: Deckert, Jürgen
name: Rietschel, Marcella
name: Berger, Klaus
name: Grabe, Hans J.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: Childhood maltreatment affects 20–30% of the German population and is an important risk factor for physical and mental diseases in adult life. This study reports first results of the distribution of childhood maltreatment in the population-based mega cohort German National Cohort (NAKO) and estimates associations with affective symptoms in adulthood. The Childhood Trauma Screener (CTS), a short version of the Childhood Trauma Questionnaire, was used in 83,995 adults (age: 20–72 years; 47.3% men) of NAKO. The five-item CTS assesses the severity of three types of childhood abuse and two types of childhood neglect. Overall, 21,131 participants (27.5%) reported at least one type of childhood maltreatment; 14,017 participants (18.3%) reported exactly one type and 250 participants (0.3%) reported all five types of childhood maltreatment. Small differences regarding age (mean absolute deviation around the mean (MAD)=0.47), sex (MAD = 0.07) and education (MAD = 0.82) were observed. The severity of childhood maltreatment was associated with more severe symptoms of depression (β = 0.23), anxiety (β = 0.21) and perceived stress (β = 0.23) in adulthood, validated particularly for emotional abuse and emotional neglect. The distribution of childhood maltreatment in NAKO is similar to previous reports. Additionally, our results suggest differential associations with psychopathological symptoms for the five types of childhood maltreatment.
Niponia nodulosa Verhoeff 1931
Creators: name: Liu, Weixin
name: Huo, Qingbo
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Polydesmida
Cryptodesmidae
Niponia
Niponia nodulosa

description: Niponia nodulosa Verhoeff, 1931, new record from continental China
Figs 1–3
Niponia nodulosa Verhoeff, 1931: 442, figs 46–55.
Niponia nodulosa— Golovatch et al., 2011: 120, figs 1–3.
Niponia nodulosa— Golovatch, 2016: 34.
Material examined: 2 males, 2 females (SCAU), 1 male, 1 female, 2 juveniles (YZU), China, Jiangsu Province, Yangzhou City, Hanjiang district, Yangzhou University Hehuachi Campus, 32°22’59.61”N, 119°25’27.87”E, 12 m a.s.l., 2018-VI-10. 1 male (SCAU), Zhejiang Province, Kaihua County, Gutian, 29°14.787′N, 118°7.496′E, 435 m a.s.l., 2018-X-9, all Qing-Bo Huo leg.
Remarks: This species is very common in southern Japan, Taiwan and also has been recorded from Vietnam (Golovatch et al. 2011, Golovatch 2016). The new samples almost fully agree with the original description and the later detailed redescription (Verhoeff 1931, Golovatch et al. 2011). The habitus and gonopodal structure (Figs 1–3) are illustrated here to document the species’ identity.
Willows are very common in Yangzhou City, Jiangsu Province. Most samples of N. nodulosa have been collected from dead willows by the second author during a study of termite infestations.
description: Published as part of Liu, Weixin & Huo, Qingbo, 2020, Two new species and a new record of polydesmoid millipedes from Jiangsu and Zhejiang provinces, eastern China (Diplopoda, Polydesmida), pp. 41-49 in Zootaxa 4722 (1) on page 42, DOI: 10.11646/zootaxa.4722.1.3, http://zenodo.org/record/3603656
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor
Creators: name: Mangano T
name: Strachan R.T
name: Braz J.M
name: Roth B.L
name: Craik V
name: Levit Kaplan A
name: Basbaum A.I
name: Shoichet B.K
name: O’Donnell H
name: Lak P
name: Slocum S
name: Amabo V
Publisher: name: American Chemical Society
Year: 2022

description: The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists exist, remains the least understood serotonin receptor. A single commercial antagonist, SB-699551, has been widely used to investigate the 5-HT5AR function in neurological disorders, including pain, but this molecule has substantial liabilities as a chemical probe. Accordingly, we sought to develop an internally controlled probe set. Docking over 6 million molecules against a 5-HT5AR homology model identified 5 mid-μM ligands, one of which was optimized to UCSF678, a 42 nM arrestin-biased partial agonist at the 5-HT5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. Site-directed mutagenesis supported the docked pose of UCSF678. Surprisingly, analogs of UCSF678 that lost the 5-HT5AR activity revealed that 5-HT5AR engagement is nonessential for alleviating pain, contrary to studies with less-selective ligands. UCSF678 and analogs constitute a selective probe set with which to study the function of the 5-HT5AR.
TIBBIYOT OLIY TA`LIM MUASSASALARIDA LINGVODIDAKTIK TAFAKKURNI RIVOJLANTIRISH ORQALI TALABALARDA INGLIZ TILINI O`QITISH SAMARADORLIGINI OSHIRISH
Creators: name: KADIROVA, GO`ZAL
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada tibbiyot OTM talabalariga ingliz tilini o`qitish sifatini baholash indekatorlarini shakllantirish masalasi, xususan, ingliz tilini o`qitish  jarayonini baholash   ko`rsatgichlari va mezonlari masalаsi tahlili bayon qilingan.
The Continuing Trouble with the Congo
Creators: Autesserre, Severine
Publisher: name: Columbia University
Year: 2012
Subjects: Civil war
Ethnic conflict
Peace-building

description: It is crucial to understand the reasons for the continuation of violence in the Congo. The Congolese conflict is one of the deadliest since World War II. It has resulted in more than five million casualties so far. It has destabilized most of Central Africa for the past sixteen years, and it remains one of the largest ongoing humanitarian crises in the world.
Cheilea Modeer 1793
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Hipponicidae
Cheilea

description: Genus Cheilea Modeer, 1793
Type species. Patella equestris Linnaeus, 1758 (Modeer 1793: 110), by subsequent designation, (Woodring, 1928). Present-day, Indian Ocean.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 38, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Structure-based design of bitopic ligands for the µ-opioid receptor
Creators: name: Al-Hasani R
name: Kobilka B.K
name: Skiniotis G
name: Madasu M.K
name: Faouzi A
name: Slocum S.T
name: Xu J
name: Varga B.R
name: El Daibani A
name: Roth B.L
name: Qu Q
name: Majumdar S
name: Wang H
name: Eans S.O
name: Che T
name: Zaidi S.A
name: Zhang T
name: Ruiz C
name: Robertson M.J
name: DiBerto J.F
name: Appourchaux K
name: Pan Y.X
name: Liu S
name: McLaughlin J.P
name: Katritch V
name: Cameron M.D
Publisher: name: Nature Research
Year: 2023

description: Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain management, but are considered a major public health concern owing to their adverse side effects, including lethal overdose1. Here, in an effort to design safer therapeutic agents, we report an approach targeting a conserved sodium ion-binding site2 found in µOR3 and many other class A G-protein-coupled receptors with bitopic fentanyl derivatives that are functionalized via a linker with a positively charged guanidino group. Cryo-electron microscopy structures of the most potent bitopic ligands in complex with µOR highlight the key interactions between the guanidine of the ligands and the key Asp2.50 residue in the Na+ site. Two bitopics (C5 and C6 guano) maintain nanomolar potency and high efficacy at Gi subtypes and show strongly reduced arrestin recruitment—one (C6 guano) also shows the lowest Gz efficacy among the panel of µOR agonists, including partial and biased morphinan and fentanyl analogues. In mice, C6 guano displayed µOR-dependent antinociception with attenuated adverse effects, supporting the µOR sodium ion-binding site as a potential target for the design of safer analgesics. In general, our study suggests that bitopic ligands that engage the sodium ion-binding pocket in class A G-protein-coupled receptors can be designed to control their efficacy and functional selectivity profiles for Gi, Go and Gz subtypes and arrestins, thus modulating their in vivo pharmacology.
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter
Creators: name: Billesbølle, C.B
name: Lak, P
name: Seth, A
name: Rudnick, G
name: Roy, K
name: Braz, J
name: O'Donnell, H
name: Singh, I
name: Sandtner, W
name: Bekele, B
name: Wetsel, W.C
name: Craik, V
name: Manglik, A
name: Shoichet, B.K
name: Irwin, J.J
name: Huang, X.-P
name: Basbaum, A.I
name: Pogorelov, V.M
name: Roth, B.L
name: Rodriguiz, R.M
name: Boytsov, D
Publisher: name: Elsevier B.V.
Year: 2023

description: The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state except ibogaine, which has unusual anti-depressant and substance-withdrawal effects, and stabilizes the inward-open conformation. Unfortunately, ibogaine's promiscuity and cardiotoxicity limit the understanding of inward-open state ligands. We docked over 200 million small molecules against the inward-open state of the SERT. Thirty-six top-ranking compounds were synthesized, and thirteen inhibited; further structure-based optimization led to the selection of two potent (low nanomolar) inhibitors. These stabilized an outward-closed state of the SERT with little activity against common off-targets. A cryo-EM structure of one of these bound to the SERT confirmed the predicted geometry. In mouse behavioral assays, both compounds had anxiolytic- and anti-depressant-like activity, with potencies up to 200-fold better than fluoxetine (Prozac), and one substantially reversed morphine withdrawal effects.
DUTORDA IJRO QILISH TEXNIKALARI ORQALI ARUZ METRORITMIK QONUNLARINI O'RGANISH HAQIDA
Creators: name: Abdurashidova Dilrabo Abduvaliyevna
Publisher: name: Academic Scientific Research Group
Year: 2024

description: Ushbu maqolada dutor chalish usullaridan foydalangan holda aruz metroritmikasi qonunlarini o‘rganish uchun empirik usul qo‘llaniladi. Hozirgi zamon musiqashunosligida birinchi marta she’rning metroritmikasi cholg‘u asbobining zarbli kombinatsiyalari bilan bog‘liq holda o‘rganiladi. Ma’lum bo‘lishicha, atoninning metroriitmik va bo‘g‘in tizimi dutor zarblari bilan mahorat bilan o‘zlashtiriladi. Vofir, komil, ramal, hazaj, rajaz, mutadorik va mutaqorib - aruz she’riy tizimining invariant metroriitmik tuzilmalari dutor sozi ijrochilari tomonidan oson ijro etilishi, koʻrsatilishi va oʻrganilishi aniqlandi.
Ohje tutkimusaineiston kuvailuun
Creators: name: AVOTT Avoimen tieteen ja tutkimuksen koordinaatio
Publisher: name: Zenodo
Year: 2024

description: Tässä tekstikokonaisuudessa luodaan yleiskatsaus aineistonkuvailun keskeisimpiin elementteihin tutkijan näkökulmasta. Tarkoitus on helpottaa tutkijalukijaa orientoitumaan kuvailutyöhön ja avata yleisellä tasolla siihen liittyviä prosesseja. 

Tiedostoon Ohje tutkimusaineistojen kuvailuun 20250107 on päivitetty linkit. Tiedostoon ei ole tehty muita muutoksia.

This guide provides an overview of the essential elements in research data description. It aims to orient researchers to the processes of data description and to open up these processes on a general level.
PECULIARITIES OF THE NATIONAL LEGISLATION OF THE REPUBLIC OF UZBEKISTAN ON MIGRATION
Creators: name: Ishankhodjaev, Saidakhmad
Publisher: name: Zenodo
Year: 2024

description: In the article, the scope of the work carried out on the regulation of migration processes in the Republic of Uzbekistan and its legal basis were studied in recent years, and proposals were put forward regarding the prospects for the development of legislation in the field of migration.
Ohje tutkimusaineiston kuvailuun
Creators: name: AVOTT Avoimen tieteen ja tutkimuksen koordinaatio
Publisher: name: Zenodo
Year: 2024

description: Tässä tekstikokonaisuudessa luodaan yleiskatsaus aineistonkuvailun keskeisimpiin elementteihin tutkijan näkökulmasta. Tarkoitus on helpottaa tutkijalukijaa orientoitumaan kuvailutyöhön ja avata yleisellä tasolla siihen liittyviä prosesseja.
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor
Creators: name: Chen, G
name: Kalyanaraman, C
name: Irwin, J.J
name: Basbaum, A.I
name: Moroz, Y.S
name: Gahbauer, S
name: Bouvier, M
name: Du, Y
name: Webb, C.M
name: Gmeiner, P
name: Schmidt, M.F
name: Hübner, H
name: Avet, C
name: Liu, Z
name: Weikert, D
name: Shoichet, B.K
name: Xu, J
name: Jacobson, M.P
name: Tolmachova, N.A
name: Craik, V
name: Braz, J.M
name: Seemann, P
name: Fink, E.A
name: Huang, X.-P
Publisher: name: American Association for the Advancement of Science
Year: 2022

description: Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α2A-adrenergic receptor (α2AAR), seeking new α2AAR agonists chemotypes that lack the sedation conferred by known α2AAR drugs, such as dexmedetomidine. We identified 17 ligands with potencies as low as 12 nanomolar, many with partial agonism and preferential Gi and Go signaling. Experimental structures of α2AAR complexed with two of these agonists confirmed the docking predictions and templated further optimization. Several compounds, including the initial docking hit ‘9087 [mean effective concentration (EC50) of 52 nanomolar] and two analogs, ‘7075 and PS75 (EC50 4.1 and 4.8 nanomolar), exerted on-target analgesic activity in multiple in vivo pain models without sedation. These newly discovered agonists are interesting as therapeutic leads that lack the liabilities of opioids and the sedation of dexmedetomidine.
Determinants of Capacity Utilization of Firms: A Comparative Analysis of Developing and Developed Countries
Creators: name: Muhammad Zahid1; Muhammad Faraz Riaz2; Anam Shehzadi3; Sadia Ali4
Publisher: name: JCMI
Year: 2024

description: This paper employs data from more than 100 World Bank Enterprise Surveys of different developed and developing countries to analyze the determinants of capacity utilization in firms between 2007-2023. Appling Tobit model, the results show that while developed countries have more access to capital, technology, reliable electricity, better management, and sound infrastructure with fewer challenges, In developing countries problems such as energy constraints, informal competition limit capacity utilization of firms. Whereas the ownership concentration has mixed effects. The analysis also highlights the importance availability to finance, digital readiness, innovation, and choice of destination market. Results also highlight that access to finance and inadequate supply of workers are the biggest challenges the firms face in the wake of capacity utilization.
Schoengastiella (Radfordiella) hipposideros Audy 1952
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Walchiidae
Schoengastiella
Schoengastiella hipposideros

description: Schoengastiella (Radfordiella) hipposideros Audy, 1952:
ORI
Schoengasitiella hipposideros Audy, 1952
Schoengastiella (Schoengastiella) hipposideros, Vercammen-Grandjean 1968c [punctata group]
Schoengastiella (Radfordiella) hipposideros, Kolebinova & Vercammen-Grandjean 1978
Schoengastiella hipposideros, Stekolnikov 2021
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Structure, function and pharmacology of human itch GPCRs
Creators: name: Roth, B.L.
name: Liu, Y
name: Kroeze, W.K
name: McCorvy, J.D
name: Fay, J.F
name: Chen, H
name: Singh, I
name: Jin, J
name: Gumpper, R.H
name: Liu, J
name: Olsen, R.H.J
name: Abraham, S.N
name: Slocum, S.T
name: DiBerto, J.F
name: English, J.G
name: Karpiak, J
name: Zhang, C
name: Bender, B.J
name: Kim, K
name: Zhang, S
name: Lansu, K
name: Krumm, B.E
name: Shoichet, B.K
name: Kang, H.J
name: Cao, C
name: Jan, L.Y
name: Hayes, B.W
name: Ye, W
name: Huang, X.-P
Publisher: name: Nature Research
Year: 2021

description: The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions2–5. MRGPRX2 couples to both Gi and Gq in mast cells6. Here we describe agonist-stabilized structures of MRGPRX2 coupled to Gi1 and Gq in ternary complexes with the endogenous peptide cortistatin-14 and with a synthetic agonist probe, respectively, and the development of potent antagonist probes for MRGPRX2. We also describe a specific MRGPRX4 agonist and the structure of this agonist in a complex with MRGPRX4 and Gq. Together, these findings should accelerate the structure-guided discovery of therapeutic agents for pain, itch and mast cell-mediated hypersensitivity.