cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A apropriação cristã da iconografia greco-latina: o tema do Bom Pastor
Creators: name: Eusébio, Maria De Fátima
Publisher: name: Máthesis
Year: 2005

description: A estruturação de uma nova religião − o cristianismo − não representou uma ruptura com a cultura e a arte greco-romanas. Contrariamente, verificou-se a apropriação de símbolos e imagens, que vão ser integradas em novos esquemas compositivos e dotadas de um significado distinto em correspondência com os novos princípios doutrinários. Neste quadro tem particular evidência a imagem do Crióforo greco-latino, cujo modelo formal se perpetuou na arte cristã sob a forma do Bom Pastor.
description: Máthesis, n. 14 (2005)
Additional file 4 of WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target
Creators: name: Zhou, Bin
name: Jin, Xianghong
name: Jin, Weiwei
name: Huang, Xingzhou
name: Wu, Yanfei
name: Li, Haiying
name: Zhu, Weijian
name: Qin, Xiaoyi
name: Ye, Haige
name: Gao, Shenmeng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 4: Table S2. The sequences of primers for qRT-PCR and construction of plasmids.
Cierpienie w życiu kapłana według Josepha Ratzingera
Creators: name: Bachanek, Grzegorz
Publisher: name: figshare
Year: 2017
Subjects: Religious Studies

description: DAS LEIDEN IM LEBEN EINES PRIESTERS NACH JOSEPH RATZINGER
Warszawskie Studia Teologiczne 27/1(2014), 257-270
Income Poverty Among Aboriginal Families with Children: Estimates from the 1986 Census
Creators: name: Whiteford, Peter
name: Ross, Russell
Publisher: name: UNSW Sydney
Year: 1990
Subjects: Poverty
Aboriginal families
Australia

description: This paper brings together information from the 1986 Census of Population and Dwellings and the 1986 Income Distribution Survey to estimate poverty rates for Aboriginal families and other families. It also describes the factors associated with income poverty among Aboriginal families. The analysis in this paper is primarily descriptive and is limited to measuring income poverty using the Henderson poverty line. The main objective is to provide the first estimates of poverty among Aboriginal families with children since the early 1970s. The results confirm that in 1986, the common perception that income poverty rates are much higher among the Aboriginal population than among the non-Aboriginal population, although the gap is less dramatic for sole parent families than it is for two parent families. The major factor associated with this poverty is joblessness, with over half of all Aboriginal families with children having no employed adults. However, poverty is still higher among those Aboriginal families with children in which there is at least one employed adult than it is among comparable non-Aboriginal families with children
description: SPRC Discussion Paper; 20
РОССИЯ ВЕРНУЛАСЬ В АФРИКУ
Creators: name: Мухинда Феликс Роджерс
Publisher: name: Международные отношения и общество
Year: 2019
Subjects: международные отношения
региональная безопасность
Африка
Россия
экономическое сотрудничество
военнотехническое сотрудничество

description: В статье рассматривается современное состояние отношений и сотрудничества между Россией и Африкой. Анализируются причины возвращения России в Африку. Показываются привлекательность и значение Африки в мировой политике и экономике. Также рассматриваются перспективы и возможности их сотрудничества. Отношения между Россией и африканскими странами основаны на разработке природных ресурсов, ядерных технологий, создании спутниковых информационно коммуникационных систем, сотрудничестве в военно-технической сфере, гидроэнергетике, образовании и здравоохранении. Особое внимание уделено раскрытию политических и экономических отношений между Россией и Африкой. Россия имеет уникальные отношения с Африкой, заложенные во времена Советского Союза, которые помогли многим африканским странам не только обрести независимость, но и их становлению и развитию. Кроме того, она не участвовала в работорговле. Таким образом, Россия может использовать эти тесные отношения, созданные Советским Союзом, в своих интересах.
Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis
Creators: name: Mao, Yong-Zhong
name: Jiang, Ling
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Computational Biology

description: At present, with the improvement of living standards and population aging, the incidence of cardiovascular and cerebrovascular disease is on the rise and has been a serious threat to human health. Statistics show that the current death caused by cardiovascular and cerebrovascular disease has become the first cause of death has been increasing year by year. Therefore, studies on coronary heart disease and atherosclerosis (AS) have become a hot topic in clinical and basic research. In this study, the question of the effect of Notch signalling pathway on the relationship between endothelial dysfunction and endothelial stromal transformation in AS was studied in depth. Based on our results, we drew conclusions as follows. First, the Notch signalling pathway was activated in the atherosclerotic model; secondly, the Notch signalling pathway was demonstrated to enhance AS by promoting vascular endothelial dysfunction; thirdly, it was demonstrated that the Notch signalling pathway was mediated by promoting endothelial and to enhance AS; finally, we confirmed the endothelial function through the Notch signalling pathway to affect the transformation of endothelial stroma to achieve synergistic AS effect. The results of this study have a good guiding significance for the important role of Notch signalling in AS and indicate the ability to influence endothelial function and endothelial stromal transformation by intervening Notch signalling pathway and can affect the relationship between them, and thus eventually achieve the treatment of AS.
title: Carnet avec des notes
title: Carnet avec des notes
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Source: Fonds Anatole Le Braz. Centre de Recherche Bretonne et Celtique (CRBC). Bibliothèque Yves-Le Gallo.
description: Provenance: Ce document provient du fonds Anatole Le Braz conservé au Centre de recherche bretonne et celtique. Les documents ont été déposés en 1986 par l’un des petits-enfants d’Anatole Le Braz et par Yann-Ber Piriou en 1999.
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description: IIIF manifest
Additional file 8 of WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target
Creators: name: Zhou, Bin
name: Jin, Xianghong
name: Jin, Weiwei
name: Huang, Xingzhou
name: Wu, Yanfei
name: Li, Haiying
name: Zhu, Weijian
name: Qin, Xiaoyi
name: Ye, Haige
name: Gao, Shenmeng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 8: Table S3. Limiting dilution assay of MLL-AF9-induced mouse leukemia transduced with sh-nc or sh-wt1.
Trzecia tajemnica fatimska w teologicznej refleksji Josepha Ratzingera.pdf
Creators: name: Bachanek, Grzegorz
Publisher: name: figshare
Year: 2017
Subjects: Religious Studies

description: Das „dritte Geheimnis” von Fatima in der theologischen Reflexion von Joseph Ratzinger
Salvatoris Mater 13(2011)1-2, 219-229.
A randomized, double-blind, parallel-group, phase III study of shortening the dosing interval of subcutaneous tocilizumab monotherapy in patients with rheumatoid arthritis and an inadequate response to subcutaneous tocilizumab every other week: Results of the 12-week double-blind period
Creators: name: Ogata, Atsushi
name: Tanaka, Yoshiya
name: Ishii, Tomonori
name: Motohide Kaneko
name: Miwa, Hiroko
name: Ohsawa, Shino
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine

description: Objective: To determine the efficacy and safety of subcutaneous tocilizumab (TCZ-SC) monotherapy every week (qw) versus every other week (q2w) in patients with rheumatoid arthritis who had an inadequate response to TCZ-SC q2w. Methods: Adult patients in Japan with inadequate response to TCZ-SC q2w were randomized to either TCZ-SC 162 mg qw monotherapy or TCZ-SC 162 mg q2w monotherapy for 12 weeks (double-blind). The primary endpoint was the change from baseline in adjusted Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR) at week 12. Efficacy, safety and pharmacokinetics were assessed. Results: TCZ-SC qw was superior to TCZ-SC q2w for adjusted mean change in DAS28-ESR from baseline to week 12. The difference in the change in DAS28-ESR between TCZ-SC qw and q2w was −1.21 (95%CI: −2.13, −0.30, p = .0108). A higher proportion of patients receiving TCZ-SC qw achieved DAS28-ESR remission/low disease activity than TCZ-SC q2w. Adverse events were 71.4% and 66.7% for TCZ-SC qw and q2w, respectively; infection was the most common event with one fatal case with TCZ-SC qw. Conclusions: In patients with inadequate response to TCZ-SC q2w, shortening the dosing interval to qw improved efficacy with acceptable tolerability. Occurrence of infection for both TCZ q2w and qw is important and needs careful attention.
Biologic treatment eligibility for real-world patients with severe asthma: The IDEAL study
Creators: name: Albers, Frank C.
name: Müllerová, Hana
name: Gunsoy, Necdet B.
name: Shin, Ji-Yeon
name: Nelsen, Linda M.
name: Bradford, Eric S.
name: Cockle, Sarah M.
name: Suruki, Robert Y.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Objectives: Severe asthma comprises several distinct phenotypes. Consequently, patients with severe asthma can be eligible for more than one biologic treatment targeting Th2 inflammation, such as anti-interleukin (IL)-5 and anti-immunoglobulin (Ig) E. The objective of this study was to describe treatment eligibility and overlap in treatment eligibility for mepolizumab (anti-IL-5), omalizumab (anti-IgE) and reslizumab (anti-IL-5) in patients with severe asthma, who were recruited from clinical practice. Methods: This cross-sectional, single-visit, observational study in six countries enrolled patients with severe asthma (defined by American Thoracic Society/European Respiratory Society guidelines). Assessable patients were analysed as a total cohort and a sub-cohort, who were not currently receiving omalizumab. Treatment eligibility was defined according to the local prescribing information or protocol-defined inclusion/exclusion criteria. Patients currently receiving omalizumab were automatically categorised as omalizumab-eligible. Results: The total cohort comprised 670 patients who met the analysis criteria, of whom 20% were eligible for mepolizumab, 31–41% were eligible for omalizumab (depending on eligibility criteria used), and 5% were eligible for reslizumab. In patients not currently receiving omalizumab (n = 502), proportions eligible for each biologic were similar (mepolizumab: 20%, reslizumab 6%) or lower (omalizumab 7–21%) than those for the total cohort. Overlap in treatment eligibility varied; in mepolizumab-eligible patients not currently receiving omalizumab (n = 101), 27–37% were omalizumab-eligible and 18% were reslizumab-eligible. Conclusions: Treatment eligibility for mepolizumab and omalizumab was higher than that for reslizumab. Although there was some overlap in treatment eligibility, the patient groups eligible for treatment with anti-IL-5 or anti-IgE therapies were often distinct, emphasising the different phenotypes and endotypes in severe asthma.
Additional file 9 of WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target
Creators: name: Zhou, Bin
name: Jin, Xianghong
name: Jin, Weiwei
name: Huang, Xingzhou
name: Wu, Yanfei
name: Li, Haiying
name: Zhu, Weijian
name: Qin, Xiaoyi
name: Ye, Haige
name: Gao, Shenmeng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 9: Table S4. Limiting dilution assay of MLL-AF9-induced mouse leukemia treated with or without WP1130.
Economic Crisis and Social Policy in Finland in the 1990s
Creators: name: Uusitalo, Hannu
Publisher: name: UNSW Sydney
Year: 1996

description: This paper discusses the social policy consequences of the exceptional economic decline in Finland in the 1990s. It asks what happened to the Finnish welfare state in these exceptional economic conditions, and consequent political problems. It describes Finland’s economic performance in a comparative perspective, studies how government(s) have defined the goals of economic and social policies, and examines how the opinions of the Finns concerning the welfare state have changed during the recession. It also looks at the welfare outcomes, focusing on income levels, income distribution, poverty and social and health services. The results suggest that Finnish households have suffered economic losses which are smaller than the decline in the GDP would predict. The findings show that equivalent income distribution and relative poverty levels have not changed during the recession. The income losses of the recession have been spread relatively evenly, and the redistribution of the welfare state has been an important tool. Finally, it is argued that the explanatory factors of the growth vis-a-vis the retrenchment of the welfare state (or the lack of it) are different. Once established, structures and institutions of the welfare state can work as powerful tools even when economic and political conditions are difficult.
description: SPRC Discussion Paper; 70
Additional file 10: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of Î˛-catenin in hepatocellular carcinoma
Creators: name: Deng, Ling
name: Sun, Jingyuan
name: Chen, Xiaohui
name: Liu, Li
name: Wu, Dehua
Publisher: name: figshare
Year: 2019
Subjects: Medicine
Cell Biology
Developmental Biology
Cancer
Hematology
Virology

description: Table S3. Univariate and multivariate analyses of OS in 102 HCC patients by Cox regression analysis. (DOCX 14 kb)
Trzecia_tajemnica_fatimska_w_teologicznej_refleksji_Josepha_Ratzingera.pdf
Creators: name: Bachanek, Grzegorz
Publisher: name: figshare
Year: 2017
Subjects: Religious Studies

description: Das „dritte Geheimnis” von Fatima in der theologischen Reflexion von Joseph Ratzinger
Salvatoris Mater 13(2011)1-2, 219-229.
Implementing Increased Transparency, and Reproducibility in Economics
Creators: name: Vilhuber, Lars
Publisher: name: Zenodo
Year: 2020
Subjects: reproducibility
verification
economics

description: Replicability is at the core of the scientific enterprise. In the past 30 years, recurring concerns about the extent of replicability (or lack thereof) of the research in various disciplines have surfaced, including in economics. In this talk, I describe the context in which the current discussion in the social science is occurring: what are the definitions of replicability and reproducibility, what is failing, and to what extent. I discuss progess over the past 15 years. Finally, I discuss the concrete measures that have been implemented under my guidance at the American Economic Association, and the first preliminary outcomes from those measures. I conclude with some observations on how to integrate reproducibility into the scientific workflow in the social and statistical sciences. The solutions to these problems will change the way research will be taught and conducted, in economics in particular, and in the social sciences more broadly. The implications affect undergraduate and graduate teaching, research infrastructure, and habits. (Short version of talk - for longer versions, see f.i. https://doi.org/10.5281/zenodo.3666011) Presented at "Love Your Code" at ONS, London, UK on February 14, 2020.
description: The opinions expressed in this talk are solely the authors, and do not represent the views of the U.S. Census Bureau, the American Economic Association, or any of the funding agencies.
Towards a Balanced Vision: The Role of Social Goals, Social Policies and Social Benchmarks
Creators: name: Saunders, Peter
Publisher: name: UNSW Sydney
Year: 1994
Subjects: Economic Progress
Social Justice
Australia

description: The main aim of the report is to emphasise the need for strategic visions for Australia to embrace and incorporate a social dimension if they are to be both balanced and relevant. It argues that economic progress does not occur in a social vacuum and focuses on the longer-term role of social goals and policies in the context of a re-invigorated and vibrant economy. Economic performance is important in determining the material standards which the population is able to enjoy, but many social goals are achievable in their own terms, irrespective of economic constraints. Others will assist, not impede, economic progress. Social policy, like all areas of government policy, is a means toward an end, and the ultimate objective of all social policies is the achievement, or at least the enhancement, of social justice. A balanced approach to development must thus combine economic progress with social justice, as must any future vision for national performance.
description: Reports and Proceedings; 116
Additional file 1 of Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer
Creators: name: Altunel, Erdem
name: Roghani, Roham S.
name: Chen, Kai-Yuan
name: Kim, So Young
name: McCall, Shannon
name: Ware, Kathryn E.
name: Shen, Xiling
name: Somarelli, Jason A.
name: Hsu, David S.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Supplementary Figure 1. RNA-Seq data to identify fusion and mutations in FGFR1–4. Supplementary Figure 2. Precision Medicine Strategy for Metastatic Colorectal Cancer. Supplementary Figure 3. Uncropped western blots showing all the bands with the molecular weight markers.
Health comorbidities and cognitive abilities across the lifespan in Down syndrome.
Creators: name: Startin, Carla M
name: D'Souza, Hana
name: Ball, George
name: Hamburg, Sarah
name: Hithersay, Rosalyn
name: Hughes, Kate MO
name: Massand, Esha
name: Karmiloff-Smith, Annette
name: Thomas, Michael SC
name: LonDownS Consortium
name: Strydom, Andre
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: subject: Model organisms
subject: Signalling & Oncogenes
subject: Developmental Biology
subject: Human Biology & Physiology
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine

description: BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression analyses were performed to determine whether the presence of health comorbidities or physical phenotypes predicted cognitive abilities. RESULTS: Multiple comorbidities showed prevalence differences across the lifespan, though there were few sex differences. In adults, SMRs were increased in males and decreased in females with DS for schizophrenia, bipolar disorder, and anxiety. Further, SMRs were increased in both males and females with DS for dementia, autism, ADHD, and depression, with differences more pronounced in females for dementia and autism, and in males for depression. Across the lifespan, receptive language abilities increasingly deviated from age-typical levels, and males scored poorer than females. Only autism and epilepsy were associated with poorer cognitive ability in those aged 16-35 years, with no relationships for physical health comorbidities, including congenital heart defects. CONCLUSIONS: Our results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities.
Supplementary information from Zebrafish lipid droplets regulate embryonic ATP homeostasis to power early development
Creators: name: Asmita Dutta
name: Sinha, Deepak Kumar
Publisher: name: The Royal Society
Year: 2017
Subjects: Biophysics
Biochemistry
Cell Biology
Developmental Biology

description: In zebrafish embryos, the maternally supplied pool of ATP is insufficient to power even the earliest of developmental events (0–3 hpf) such as oocyte-to-embryo transition (OET). The embryos generate additional pulse (2.5 h long) of ATP (1.25–4 hpf) to achieve the embryonic ATP homeostasis. We demonstrate that the additional pulse of ATP is needed for successful execution of OET. The maternally supplied yolk lipids play a crucial role in maintaining the embryonic ATP homeostasis. In this paper, we identify the source and trafficking routes of free fatty acids (FFAs) that feed the mitochondria for synthesis of ATP. Interestingly, neither the maternally supplied pool of yolk-FFA nor the yolk-FACoA (Fatty Acyl Coenzyme A) is used for ATP homeostasis during 0–5 hpf in zebrafish embryos. With the help of lipidomics, we explore the link between lipid droplets (LDs) mediated lipolysis and ATP homeostasis in zebrafish embryos. Until 5 hpf, the embryonic LDs undergo extensive lipolysis that generates FFAs. We demonstrate that these newly synthesized FFAs from LDs are involved in the maintenance of embryonic ATP homeostasis, rather than the FFAs/FACoA present in the yolk. Thus, the LDs are vital embryonic organelles that maintain the ATP homeostasis during early developmental stages (0–5 hpf) in zebrafish embryos. Our study highlights the important roles carried on by the LDs during the early development of the zebrafish embryos.
Supplementary Figures from Chemoselective Lewis pair polymerization of renewable multivinyl-functionalized γ-butyrolactones
Creators: name: Ravikumar R. Gowda
name: Chen, Eugene Y.-X.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: 39904 Organometallic Chemistry

description: Multivinyl-functionalized γ-butyrolactones, γ-vinyl-γ-methyl-α-methylene-γ-butyrolactone (γVMMBL) and γ-allyl-γ-methyl-α-methylene-γ-butyrolactone (γAMMBL), have been synthesized from biorenewable ethyl levulinate and effectively polymerized by Lewis pairs consisting of an organic N-heterocyclic carbene Lewis base and a strong organo-Lewis acid E(C6F5)3 (E = Al, B). This Lewis pair polymerization is quantitatively chemoselective, proceeds exclusively via polyaddition across the conjugated α-methylene double bond without participation of the γ-vinyl or γ-allyl double bond, and produces high molecular weight functionalized polymers with unimodal molecular weight distributions. The Al-based Lewis pair produces the polymer with approximately 5.5 times higher molecular weight than that by the B-based Lewis pair. The resulting vinyl-functionalized polymers are soluble in common organic solvents and stable at room temperature, and can be thermally cured into crosslinked materials.
Additional file 1 of New targeted approaches for epigenetic age predictions
Creators: name: Han, Yang
name: Franzen, Julia
name: Stiehl, Thomas
name: Gobs, Michael
name: Kuo, Chao-Chung
name: Nikolić, Miloš
name: Hapala, Jan
name: Koop, Barbara Elisabeth
name: Strathmann, Klaus
name: Ritz-Timme, Stefanie
name: Wagner, Wolfgang
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Demarcation of age-associated CpGs in Illumina BeadChip datasets. Figure S2. Comparison with epigenetic ageing clocks of Horvath and Hannum. Figure S3. Intersection of probes among different epigenetic ageing clocks. Figure S4. Selection of 6 CpG markers for pyrosequencing. Figure S5. Comparison of DNAm levels in pyrosequencing and BBA-seq. Figure S6. Comparison of age-associated DNAm in ddPCR versus BBA-seq. Figure S7. Correlation of DNAm with age in buccal swabs. Figure S8. Targeted sequences of pyrosequencing assays. Figure S9. Targeted sequences for BBA-seq. Table S1. DNAm profiles for candidate CpG selection. Table S2. Multivariable 65 CpG model for Illumina BeadChip data. Table S3. Primer list for Pyrosequencing assays. Table S4. Epigenetic aging signature based on pyrosequencing (6 CpG model). Table S5. Epigenetic aging signature based on pyrosequencing (9 CpG model). Table S6. Primer list for ddPCR assay. Table S7. Multivariable model for ddPCR (7 CpG). Table S8. Primer list for BBA-seq assay. Table S9. Multivariable model for BBA-seq of blood (9 CpG model). Table S10. Multivariable model for BBA-seq of buccal swabs (9 CpG model). Table S11. Machine learning model by Lasso (blood). Table S12. Machine learning model by ElasticNet (blood). Table S13. Machine learning model by Lasso (swab). Table S14. Machine learning model by ElasticNet (swab).
Additional file 1 of Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer
Creators: name: Chen, Jian
name: Tan, Yun
name: Sun, Fenghuan
name: Hou, Likun
name: Zhang, Chi
name: Ge, Tao
name: Yu, Huansha
name: Wu, Chunxiao
name: Zhu, Yuming
name: Duan, Liang
name: Wu, Liang
name: Song, Nan
name: Zhang, Liping
name: Zhang, Wei
name: Wang, Di
name: Chen, Chang
name: Wu, Chunyan
name: Jiang, Gening
name: Zhang, Peng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Additional file 1: Figure S1. Representative illustration of gene expression in single cell RNA-seq. Figure S2. Identification of cell-cell interactions between different cells in the microenvironment of NSCLC. Figure S3. CD20+ B cells inhibit the cell growth and invasion in H1299 cells. Figure S4. Plasma-like B cells exert a different effect on tumor cells in different stages of lung cancer. Figure S5. Representative illustration of TRIM21, FCGR3A, C1QA, C1QB, C1QC, AP2A1, AP2M1, AP2A2, RHOC, CTTND1 and CTNNB1 expression.
Horizontal hostility
Creators: name: Thompson, Denise
Publisher: name: UNSW Sydney
Year: 1993
Subjects: lesbian feminism
lesbian ethics
violence between women
bullying

description: The term 'horizontal hostility' was coined by Florynce Kennedy in 1970. It refers to forms of power-as-domination between and among women which spring from a position of weakness not strength. It is a type of bullying of those perceived as powerful, driven by resentment and contempt. It involves complicity with the oppressive social order of male supremacy and compliance with the belief in female weakness. The paper discusses name-calling, the inadequacy of feelings as a justification for action, how to recognise horizontal hostility, and how to avoid engaging in it.
An Object-Oriented Approach Towards a Collaborative Environment for Computer-Aided Engineering (C.A.E.)
Creators: name: Iosifidis, Philip
Publisher: name: London South Bank University
Year: 1996

description: The key of realising improved collaboration amongst engineering disciplines which are involved in large projects is integration of the complex information structures that are generated and exchanged during the life-cycle of a project. Object-orientation has emerged as an appropriate approach in handing complexity which is inherent in many engineering domains. This research adopts an object-oriented approach in modelling engineering data on a conceptual level, together with mechanisms for effective information sharing. State-of-the-art tools and processes were utilised for the implementation of a collaborative environment for the construction industry where data are maintained as objects and can be re-used and enhanced by participating disciplines. This integrated environment enables _ efficient inter-disciplinary communication which was lacking previously due to the inadequacy of conventional methods to tackle complexity, therefore resulting in a potentially more competitive and effective construction industry.
Application of a novel phyco-composite biosorbent for the biotreatment of aqueous medium polluted with manganese ions
Creators: name: Deniz, Fatih
name: Ersanli, Elif Tezel
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: A composite phyco-biomass including four different marine macroalgae species (Chaetomorpha sp., Polysiphonia sp., Ulva sp., and Cystoseira sp.) was evaluated as a novel biosorbent for the biosorption of manganese ions from aqueous solution. The experimental studies were performed to optimize the operational factors including solution pH, biosorbent amount, initial manganese concentration, and reaction time in a batch-mode biosorption system. The removal yield of the biosorbent for manganese ions increased with increasing pH, manganese ion concentration, and reaction time, while it decreased as the biosorbent dose increased. The obtained kinetic data indicated that the removal of manganese ions by the biosorbent was best described by the pseudo-second-order model and the pore diffusion also contributed to the biosorption process. The results of isotherm and thermodynamic studies showed that the Freundlich model represented the biosorption equilibrium data well and this biotreatment system was feasible, spontaneous, and physical. The maximum manganese uptake capacity of used biosorbent was found to be 55.874 mg g−1. Finally, a single-stage batch manganese biosorption system was designed and its kinetic performance was evaluated. All these findings revealed that the prepared composite macroalgae biosorbent has a fairly good potential for the removal of manganese ions from the aqueous medium.
Modellbasierte Entwicklung einer Regelungsstrategie zur aktiven Schwingungskompensation in hydraulischen Steueranordnungen mit hydraulisch-mechanischen Regelungsstrukturen
Creators: name: Paris, Jascha Norman
Publisher: name: RWTH Aachen University
Year: 2014
Subjects: subject: 620

description: Masterarbeit, RWTH Aachen University, 2014; Aachen (2014). doi:10.18154/RWTH-2020-03048 = Masterarbeit, RWTH Aachen University, 2014
description: Published by Aachen
α-Sulfonyloxylation of 1,3-dicarbonyl compounds utilizing hypervalent iodine(iii) reagent: Construction of quaternary carbon center
Creators: name: Liu, Ruojuan
name: Wang, Junzheng
name: Hu, Wen
name: Zhang, Xiaohui
name: Xiong, Yan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Space Science
Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology

description: An efficient method for direct α-sulfonyloxylation of various sterically hindered 1,3-dicarbonyl compounds has been developed under mild reaction conditions. The yields of desired products is up to 90% and a plausible mechanism was accordingly proposed.
A Concise and Facile Synthesis of (R,R)-Dexmethylphenidate Hydrochloride and Its Three Stereoisomers
Creators: name: Chunzheng Li
name: Yuanbo Ji
name: Cao, Qing
name: Jianqi Li
name: Bonan Li
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: 60506 Virology

description: A new and concise route is reported for the first time for the preparation of four stereoisomers of dexmethylphenidate hydrochloride starting from a single reactant, 2-benzyolpyridine, via an eight-step reaction process which includes hydrogenation, protection, oxidation, chiral separation, Wittig reaction, hydroboration, PDC oxidation and methyl esterification. The absolute configuration of the two chiral centers of each stereoisomer was confirmed by X-ray and chiral HPLC analysis.
Proving termination of pointer programs on top of symbolic execution
Creators: name: Fesefeldt, Ira Justus
Publisher: name: RWTH Aachen University
Year: 2019
Subjects: subject: 004

description: Masterarbeit, RWTH Aachen University, 2019; Aachen 118 S. (2019). doi:10.18154/RWTH-2020-04970 = Masterarbeit, RWTH Aachen University, 2019
description: Published by Aachen
Plasmonic dimers in a solution: A theoretical approach to the optical activity in an ensemble of randomly oriented chiral and achiral plasmonic dimers: Effect of the coupling and scattering direction
Creators: name: M. A. Kuntman
name: E. Kuntman
Publisher: name: Zenodo
Year: 2022
Subjects: plasmonic nanorod dimers, optical activity, chiral and achiral dimers in a solution, ensemble of arbitrarily oriented dimers, effect of the coupling on the optical activity

description: We define an optical activity parameter for a single plasmonic nanorod dimer in an arbitrary geometry and orientation in terms of the scattered fields and we study the optical activity in an ensemble of randomly oriented chiral and achiral plasmonic dimers by summing up the optical activity parameter over all possible orientations. We show that, for forward scattering, the optical activity parameter is a function of the coupling coefficient for all orientations of the dimer, therefore, if there is no coupling between the nanorods there will be no optical activity in an ensemble of randomly oriented chiral dimers. In other words, chiral geometry does not warrant the emergence of optical activity in an ensemble. We also study scattering in other directions. For scattering in the transverse directions with coupled nanorods the situation is similar to the forward scattering, but now there are terms that do not depend on the coupling coefficient in the expression of optical activity parameter for an arbitrarily oriented dimer. Therefore, metasurfaces formed by selecting certain orientations with uncoupled nanorods can exhibit optical actvity for scattering in transverse directions.
Concise and facile synthesis of (R,R)-dexmethylphenidate hydrochloride and its three stereoisomers
Creators: name: Chunzheng Li
name: Yuanbo Ji
name: Cao, Qing
name: Jianqi Li
name: Bonan Li
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Computational Biology

description: A new and concise route is reported for the first time for the preparation of four stereoisomers of dexmethylphenidate hydrochloride starting from a single reactant, 2-benzyolpyridine, through an eight-step reaction process, which includes hydrogenation, protection, oxidation, chiral separation, Wittig reaction, hydroboration, pyridinium dichromate oxidation, and methyl esterification. The absolute configuration of the two chiral centers of each stereoisomer was confirmed by X-ray and chiral HPLC analyses.
Application of a novel phyco-composite biosorbent for biotreatment of aqueous medium polluted with manganese ions
Creators: name: Deniz, Fatih
name: Ersanli, Elif Tezel
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: A composite phyco-biomass including four different marine macroalgae species (Chaetomorpha sp., Polysiphonia sp., Ulva sp. and Cystoseira sp.) was evaluated as a novel biosorbent for the biosorption of manganese ions from aqueous solution. The experimental studies were performed to optimize the operational factors including solution pH, biosorbent amount, initial manganese concentration and reaction time in a batch mode biosorption system. The removal yield of the biosorbent for manganese ions increased with increasing pH, manganese ion concentration and reaction time while it decreased as the biosorbent dose increased. The obtained kinetic data indicated that the removal of manganese ions by the biosorbent was best described by the pseudo-second-order model and the pore diffusion also contributed to the biosorption process. The results of isotherm and thermodynamic studies showed that Freundlich model represented the biosorption equilibrium data well and this biotreatment system was a feasible, spontaneous and physical. The maximum manganese uptake capacity of used biosorbent was found to be 55.874 mg g−1. Finally, a single-stage batch manganese biosorption system was designed and its kinetic performance was evaluated. All these findings revealed that the prepared composite macroalgae biosorbent has a fairly good potential for the removal of manganese ions from aqueous medium.
Computational Complexity of UAP Reverse Engineering: A Formal Analysis of Automaton Identification and Data Complexity
Creators: name: Daghbouche, Karim
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computational Complexity (cs.CC)
subject: FOS: Computer and information sciences

description: This white paper demonstrates that reverse engineering Unidentified Aerial Phenomena (UAP) is NP-complete under classical computational paradigms. By modeling UAP reconstruction as an automaton identification problem with a state characterization matrix M(D, T, E) and examining the inherent challenges in data gathering as well as unknown physics, we show that inferring internal mechanisms (such as Isotopically-Engineered-Materials or unconventional propulsion systems) from finite observational data is computationally intractable. Data D, comprising both operational non-reproducible observations and reproducible analysis data from purported crash retrievals, remains inherently fragmentary. Even if UAP observables were reproducible, the absence of a comprehensive theoretical framework ensures that reverse engineering remains NP-complete, and may escalate to PSPACE-hard or to an Entscheidungsproblem. This intractability challenges current UAP reverse engineering efforts and has profound implications for transparency on UAP technology and related venture investments. Hence, UAP are as analogous to modern smartphones in the hands of Neanderthals.
description: With perpetual, non-exclusive license to distribute for arxiv.org
The location of information technology-led new economy jobs in cities: office parks or cool neighbourhoods?
Creators: name: Duvivier, Chloé
name: Polèse, Mario
name: Apparicio, Philippe
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: A growing literature suggests that central city neighbourhoods have become the focus of the information technology-driven new economy (IT-NE). Much of the evidence is based on case studies with a strong overlap with so-called ‘creative districts’. This paper examines the location of IT-NE jobs and its determinants for Canada’s three largest metropolises: Toronto, Montreal and Vancouver. IT-NE employment is spatially polarized in all three cities with a dual concentration in some suburban poles and central neighbourhoods. Econometric results suggest that ‘creative’ district attributes, although significant, are not the strongest predictors of location. Built environment, infrastructure and localization economies variables are also powerful predictors.
Additional file 5 of Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer
Creators: name: Chen, Jian
name: Tan, Yun
name: Sun, Fenghuan
name: Hou, Likun
name: Zhang, Chi
name: Ge, Tao
name: Yu, Huansha
name: Wu, Chunxiao
name: Zhu, Yuming
name: Duan, Liang
name: Wu, Liang
name: Song, Nan
name: Zhang, Liping
name: Zhang, Wei
name: Wang, Di
name: Chen, Chang
name: Wu, Chunyan
name: Jiang, Gening
name: Zhang, Peng
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Additional file 5. Review history.