cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multiproduct Multinationals and the Quality of Innovation
Creators: name: Sasan, Bakhtiari
name: Minniti, Antonio
name: Naghavi, Alireza
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: SECS-P/01 Economia politica

description: This research sheds light on the role of product scope on the innovation activity of multinational multi-product firms. We use patent citation data to break down innovation into two types by measuring the degree to which innovation performed by firms is fundamental and the extent to which the output of the R&D can be spread across different product lines. We focus on two features in multinational production: (i) fundamental innovation is geographically more difficult to transfer abroad to foreign production sites, (ii) learning spillovers can occur from international operations. The results reveal that the second effect is more likely to dominate when a firm is active in more product lines. We argue that a more diversified portfolio of products increases a firm’s scope of learning from international operations, thereby enhancing its ability to engage in more fundamental research. In contrast, firms with less product lines that geographically separate production from innovation shift the innovation activities towards more specialized types of innovation.
Kurz- bis mittelfristige Ergebnisse nach Implantation der Latitude®-Ellenbogenprothese bei verschiedenen Indikationsstellungen
Creators: name: Jahr, Ulrike Senta
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2019
Subjects: subject: Ellbogengelenkkrankheit
subject: Gelenkendoprothese
subject: 616.72

description: Diese Studie widmete sich der Untersuchung von kurz- bis mittelfristigen Ergebnissen nach Implantation der modularen Latitude®-Ellenbogenprothese. In der Orthopädischen Universitätsklinik Magdeburg wurden im Zeitraum von Ende 2005 bis Ende 2009 sowie von September 2010 bis September 2011 im Klinikum Magdeburg insgesamt 70 primäre Ellenbogenprothesen vom Typ Latitude® bei primärer und sekundärer Kubarthrose implantiert. Ein Ziel der vorliegenden Studie war es zu überprüfen, ob und wie differenziert mit einem umfassenden ellenbogen- und regionenbezogenen Untersuchungsset das funktionelle Ergebnis sowie die Lebensqualität nach Implantation der Latitude®-Ellenbogenprothese im ausgewählten Krankengut erfasst werden konnte. Zudem wurde untersucht, ob und in welchen Umfang sich die Ergebnisse bei verschiedenen Indikationsstellungen unterschieden. Diese Ergebnisse wurden denen der bereits in Anwendung befindlichen Prothesenmodellen gegenübergestellt. Anhand der vorliegenden Ergebnisse eines repräsentativen Patientenkollektivs erwies sich die Latitude®-Totalendoprothese als eine zuverlässige endoprothetische Versorgung von Patienten mit entzündlicher sowie nicht entzündlicher Gelenkdestruktion des Ellenbogengelenkes. Sowohl bei chronischer Polyarthritis als auch bei posttraumatischer und primärer Arthrose zeigte die Latitude®-Totalendoprothese vergleichbar gute Resultate wie andere Prothesenmodelle. Eine eindeutige Überlegenheit der funktionellen Ergebnisse gegenüber anderen beschriebenen Implantatsystemen lässt sich auf Grundlage der hier erhobenen Daten nicht feststellen.
Additional file 1 of Association of education background with clinical pharmacists’ clinical pharmacy workload in tertiary hospitals of China
Creators: name: Sun, Qingran
name: Chen, Lei
name: Huang, Yuankai
name: Xi, Xiaoyu
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health
subject: Hematology

description: Additional file 1: Appendix 1. Questionnaire for education background and workload of clinical pharmacists (English version).
Diagnose und Therapie der zervikalen Lymphadenitis durch nichttuberkulöse Mykobakterien bei Kindern mit städtischem und ländlichem Wohnsitz
Creators: name: Papatsoutsos, Efstathios
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2020
Subjects: subject: Lymphadenitis
subject: Atypische Mykobakterien
subject: Kind / 1-9 Jahre
subject: 617.53059

description: In der vorliegenden Arbeit wurden Patienten mit einer zervikalen Lymphadenitis durch nichttuberkulösen Mykobakterien im Kindesalter, die zwischen 2006 und 2016 in der Universitätsklinik Magdeburg behandelt wurden, eingeschlossen. 32 Patienten mit einer Lymphadenitis colli durch atypische Mykobakterien wurden identifiziert. Eine signifikante Korrelation zwischen dem Wohnsitz und der Charakteristika der Erkrankung konnte nicht identifiziert werden. In allen Fällen wurden ähnliche sonographische Befundekonstellationen beobachtet. Die häufigsten Befunde waren echoarme Lymphknoten mit intraglandulärer Nekrose und keiner oder niedriger Vaskularisation. Die verwendeten operativen Verfahren schließen die Abszessinzision mit Biopsie, die Lymphknotenexzision, die selektive Neck Dissection und die partielle Parotidektomie ein. Sieben Patienten entwickelten ein Rezidiv. Ein Rezidiv war signifikant häufiger nach Abszessinzision. Ein weiterer signifikanter Unterschied zwischen den operativen Methoden wurde nicht identifiziert.
Marriage Formation with Assortative Meeting as a Two-Sided Optimal Stopping Problem
Creators: name: Parilina, Elena M.
name: Tampieri, Alessandro
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: SECS-P/01 Economia politica

description: In this paper we study marriage formation through a two-sided secretary problem approach. We consider individuals with nontransferable utility and two different
dimensions of heterogeneity, a characteristic evaluated according to the idiosyncratic preferences of potential partners, and an universally-rankable characteristic. There are two possible states of the world, one in which people meet their partner randomly, and one in which the meeting occurs between individuals with similar characteristics.
We show that individuals with higher universal characteristic tend to be more picky in their marriage hunting. This does not necessarily mean that they marry later than other individuals, since the higher expected quality of their potential partners in the assortative meeting state can make them marry earlier than individuals with a lower universal characteristic.
Analysis of the low-energy $π^\pm p$ differential cross sections of the CHAOS Collaboration
Creators: name: Matsinos, Evangelos
name: Rasche, Guenther
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: This paper presents the results of an analysis of the low-energy $π^\pm p$ differential cross sections, acquired by the CHAOS Collaboration at TRIUMF \cite{chaos,denz}. We first analyse separately the $π^+ p$ and the $π^- p$ elastic-scattering measurements on the basis of standard low-energy parameterisations of the $s$- and p-wave $K$-matrix elements. After the removal of the outliers, we subject the truncated $π^\pm p$ elastic-scattering databases into a common optimisation scheme using the ETH model \cite{glmbg}; the optimisation failed to produce reasonable values for the model parameters. We conclude that the problems we have encountered in the analysis of these data are due to the shape of the angular distributions of their $π^+ p$ differential cross sections.
Revisiting Italian Emigration Before the Great War: A Test of the Standard Economic Model
Creators: name: Ardeni, Pier Giorgio
name: Gentili, Andrea
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: SECS-P/01 Economia politica

description: Among the many studies on migration before the Great War, Italy has received little attention, with a few notable exceptions and without providing a convincing explanation of its economic and demographic determinants. Standard neoclassical approaches explain emigration as driven by relative wages, relative employment rates and the stock of previous emigrants. We aim at improving on earlier contributions by covering all migration outflows from Italy to the most significant destination countries and by adopting the most consistent and up-to-date econometric approaches. As it turns out, the standard model is not fully confirmed and a more nuanced analysis is needed.
Direct Detections of Young Stars in Nearby Elliptical Galaxies
Creators: name: Ford, H. Alyson
name: Bregman, Joel N.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Small amounts of star formation in elliptical galaxies are suggested by several results: surprisingly young ages from optical line indices, cooling X-ray gas, and mid-IR dust emission. Such star formation has previously been difficult to directly detect, but using UV Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3) imaging, we have identified individual young stars and star clusters in four nearby ellipticals. This technique is orders of magnitude more sensitive than other methods, allowing detections of star formation to 10^(-5) Msun/yr. Ongoing star formation is detected in all galaxies, including three ellipticals that have previously exhibited potential signposts of star forming conditions (NGC 4636, NGC 4697, and NGC 4374), as well as the typical "red and dead" NGC 3379. The current star formation in our closest targets, where we are most complete, is between 1-8x10^(-5) Msun/yr. The star formation history was roughly constant from 0.5-1.5 Gyr (at 3-5x10^(-4) Msun/yr), but decreased by a factor of several in the past 0.3 Gyr. Most star clusters have a mass between 10^2 - 10^4 Msun. The specific star formation rates of ~10^(-16) yr^(-1) (at the present day) or ~10^(-14) yr^(-1) (when averaging over the past Gyr) imply that a fraction 10^(-8) of the stellar mass is younger than 100 Myr and 10^(-5) is younger than 1 Gyr, quantifying the level of frosting of recent star formation over the otherwise passive stellar population. There is no obvious correlation between either the presence or spatial distribution of postulated star formation indicators and the star formation we detect.
description: Accepted for publication in ApJ. 14 pages, 11 figures
title: Investigating cathelicidin as an inducible modulator of respiratory syncytial virus infection
Creators: name: Sintoris, Sofia
Publisher: name: The University of Edinburgh
Year: 2022
Subjects: subject: cathelicidin
subject: Respiratory Syncytial Virus (RSV)
subject: inducing endogenous cathelicidin in at-risk groups
subject: respiratory tract infections associated with severe disease in infants
subject: boosting cathelicidin levels

description: Respiratory Syncytial Virus (RSV) is a common cause of respiratory tract infections associated with severe disease in infants. The cationic host defence peptide cathelicidin previously demonstrated antiviral activity against RSV in vitro and in vivo, potentially via direct interaction with viral particles. Lower endogenous systemic cathelicidin levels have been linked to RSV severity in infants, while adults with higher nasal cathelicidin resisted RSV challenge. Moreover, tentative links have been made between development of the infant respiratory microbiota and cathelicidin in the context of RSV severity. These results suggest that cathelicidin may modulate RSV susceptibility. However, we are yet to elucidate age, infection, and microbiome-related changes in cathelicidin levels throughout early life and associated value of optimised endogenous cathelicidin induction in protection against severe RSV disease. Through analysis of three longitudinal infant cohorts, this thesis revealed that nasal cathelicidin was detectable after birth, increased rapidly over the first few months of life and during RSV infection and was affected by host and environmental factors including sex and birth season. Characterisation of the infant respiratory microbiota composition before, during and after RSV infection revealed temporal microbiota changes and a potential relationship with nasal cathelicidin. These findings demonstrate influence of environmental factors on early life nasal cathelicidin levels which could impact RSV susceptibility or severity, highlighting potential value of inducing endogenous cathelicidin in at-risk groups. This thesis also characterised genotype-specific differences in immune cell proportions following RSV infection in cell-specific cathelicidin knockout mice. Finally, this thesis found that organic compounds vitamin D3, phenylbutyrate and HO53 induced cathelicidin gene expression and had protective antiviral activity against low level RSV infection in a human epithelial cell line potentially via a mechanism involving type I interferon signalling. The insights gained from this thesis have enhanced understanding of the dynamics of nasal cathelicidin in early life and during initial RSV infection, as well as mechanisms of endogenous peptide induction which may inform development of targeted therapeutic cathelicidin induction approaches or lead to identification of cathelicidin levels as biomarkers of RSV susceptibility or severity.
title: Does the cellular antiviral factor RPRD2 inhibit HIV-1 by repressing viral transcription?
Creators: name: Loh, Hui Xin
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: subject: RPRD2
subject: repressing viral transcription
subject: HIV-1 DNA
subject: HUSH complex
subject: H3K9 histone trimethylation
subject: viral-derived episomal DNA

description: HIV-1 DNA integrates into the host genome, but despite this, infected cells can recruit the HUSH complex, which recognises viral intronless genes and initiates silencing of transcription through H3K9 histone trimethylation. The antiviral protein RPRD2 was recently found to be a general repressor of transcription, and is known to inhibit HIV-1 infection, although the exact mechanism of viral restriction remains unclear. Here we investigate the role of RPRD2 in repressing transcription of HIV-1 DNA and the interaction between RPRD2 and the HUSH complex. Our data show that knockdown of both RPRD2 and TASOR increased transcription of transfected lentiviral HIV-1 reporters in HEK293T cells and HeLa cells, and that the transcriptional repression is independent of the presence of introns. In contrast, our data indicate that RPRD2 does not suppress transcription of integrated HIV-1 provirus. Knockdown of RPRD2 consistently did not affect the expression of integrated HIV-1 LTR GFP reporter genes in the J-Lat latency model, in transduced HeLa cells, and with the piggyBac-integrated L1-derived reporters in HeLa cells, despite that we detected a physical interaction between RPRD2 and TASOR. Therefore, RPRD2 does not inhibit transcription of integrated HIV-1 DNA, but does restrict transfected plasmid DNA. It remains possible that RPRD2 affects episomal DNA only as is seen for other HUSH-related and HUSH-independent cellular factors. Given that episomal DNA does not contribute to HIV-1 infection, transcriptional inhibition is not the basis of the antiviral effect of RPRD2. However, these data will still aid understanding of the role and mechanism of RPRD2 in cellular transcription. Potentially, the data regarding plasmid DNA could be pertinent for understanding the suppression of viral-derived episomal DNA, including in the context of gene therapy, though this remains to be tested.
Sicherheit und Effektivität der CT-gestützten HDR-Brachytherapie von abdominalen Lymphknotenmetastasen
Creators: name: Neumann, Sophie
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2020
Subjects: subject: Brachytherapie
subject: Lymphknotenmetastase
subject: 615.842

description: In der vorliegenden Arbeit wurde die Sicherheit und Effektivität der CT-gestützten HDR- Brachytherapie von abdominalen Lymphknotenmetastasen verschiedener Tumorentitäten untersucht. Im Rahmen der Analyse wurden Patientendaten von Januar 2008 bis Dezember 2018 ausgewertet. Als primäre Endpunkte wurden die lokale Tumorkontrollrate sowie Komplikationen erfasst, die Überlebenszeiten wurden als sekundäre Endpunkte dokumentiert. Behandelt wurden im Rahmen von 75 Brachytherapien insgesamt 91 Lymphknotenmetastasen bei 55 Patienten. Die lokale Tumorkontrollrate im medianen Nachsorgezeitraum von 15,9 Monaten betrug 80,2%. Die Gesamtkomplikationsrate betrug 14,7%, die Rate an Majorkomplikationen betrug 8,0%. Die 30-Tage-Mortalität betrug 0,0%. Die mediane Gesamtüberlebenszeit betrug 21,1 Monate. Die multivariate Datenanalyse ergab keine signifikanten Einflussfaktoren auf die lokale Kontrollrate oder das Auftreten von Komplikationen. Zusammenfassend konnte gezeigt werden, dass die CT-gestützte HDR-Brachytherapie eine sichere und wirksame Methode zur Behandlung von abdominalen Lymphknotenmetastasen darstellt.
Deep Learning on Eye Gaze Data to Classify Student Distraction Level in an Educational VR Environment
Creators: name: Asish, Sarker Monojit
name: Hossain, Ekram
name: Kulshreshth, Arun K.
name: Borst, Christoph W.
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Computing methodologies
Deep learning
Virtual reality
Applied computing
Education

description: Educational VR may increase engagement and retention compared to traditional learning, for some topics or students. However, a student could still get distracted and disengaged due to stress, mind-wandering, unwanted noise, external alerts, etc. Student eye gaze can be useful for detecting distraction. For example, we previously considered gaze visualizations to help teachers understand student attention to better identify or guide distracted students. However, it is not practical for a teacher to monitor a large numbers of student indicators while teaching. To help filter students based on distraction level, we consider a deep learning approach to detect distraction from gaze data. The key aspects are: (1) we created a labeled eye gaze dataset (3.4M data points) from an educational VR environment, (2) we propose an automatic system to gauge a student's distraction level from gaze data, and (3) we apply and compare three deep neural classifiers for this purpose. A proposed CNN-LSTM classifier achieved an accuracy of 89.8% for classifying distraction, per educational activity section, into one of three levels.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: VR, Memory, and Cognition
description: 37
description: 46
description: Sarker Monojit Asish, Ekram Hossain, Arun K. Kulshreshth, and Christoph W. Borst
description: CCS Concepts: Computing methodologies --> Deep learning; Virtual reality; Applied computing --> Education
Subtle expressions of gender inequality : exploring the application of aggravating and mitigating factors in sentencing decisions for sexual assault offences
Creators: name: Burnett, Tamera Ashley Margaret
Publisher: name: University of British Columbia
Year: 2014

description: Sexual assault is a serious and prevalent crime in Canada, and the legal responses addressing this phenomenon represent a failure to truly understand its causes and harms. From the justice system’s first interactions with those affected by sexual assault to the highest levels of appeal, the legal system has shown an inability to conceptualise this offence as a systemic issue of oppression that is deeply connected to equality rights. This failure is well-illustrated in the sentencing decisions resulting from these cases: they are unpredictable, often justified using a variety of rape myths that diminish the effects of the crime, and encourage society to view sexual assault as a far less serious offence than it truly is. The academic literature on this topic, however, is sparse. This thesis fills part of that gap by exploring the use of aggravating and mitigating factors in sexual assault cases through a feminist lens. These factors prompt the courts to either increase or decrease sentences. They are meant to humanise and contextualise the sentencing process; however, their use is negatively influenced by rape myths and stereotypical assumptions about gender and the crime of sexual assault. In order to demonstrate the validity of this claim, a case law survey was prepared to qualitatively investigate contemporary jurisprudence from Ontario. The results of this research showed that aggravating factors were not consistently used when relevant, and often applied in a manner that minimised the harms suffered by the complainant. Mitigating factors, on the other hand, were used to disproportionately favour the offender by justifying or excusing his criminal behaviour. While some decisions showed that aggravating and mitigating factors can be used in a manner that challenges systemic issues of gender discrimination, this capacity for progressive change was largely ignored.
Projection Alignment Correction for In-Vehicle Projector-Camera System
Creators: name: Amano, Toshiyuki
name: Kagawa, Taichi
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Human centered computing
Mixed / augmented reality
Computing methodologies

description: In this study, we propose a projection registration method for the projections from a continuously moving vehicle for driver vision assistance during night driving. Accordingly, we employ a context-aware projection technique with adaptive pixel map- ping generation. Because vehicle movements lead to misalignment of the projection latency, a co-axial projector-camera con- figuration or high frame rate processing cannot solve this problem. However, adaptive pixel mapping corrects pixel mapping according to the vehicle speed and achieves a misalignment-free dynamic projection mapping. The effectiveness of the proposed method was evaluated through experiments using a moving projector-camera system mounted on a motorized linear stage.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: Interaction and Applications
description: 47
description: 51
description: Toshiyuki Amano and Taichi Kagawa
description: CCS Concepts: Human-centered computing --> Mixed / augmented reality; Computing methodologies --> Mixed / augmented reality
Elga Mark-Kuriku välipäevik nr 35
Creators: name: Mark-Kurik, Elga
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1989
Subjects: Estonia
Saratov and Orenburg Oblast
Devonian
outcrops

description: Field notebook with descriptions of Devonian outcrops in Estonia and Russia.
Multilayer RF PCB for space applications : technological and interconnections trade-off
Creators: name: Paillard, M.
name: Bodereau, F.
name: Drevon, C.
name: Monfraix, P.
name: Cazaux, Jean-Louis
name: Bodin, L.
name: Guyon, P.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: Multilayer RF Printed Circuits Boards withembedded passives are complex structures to manufactureand to package while keeping good RF performances. In thispaper, technological solutions aimed at simplifying theseissuesare proposed : the use of thermoset materials insteadofthermoplasticlaminates and an original interconnection technique based on "RF openings" machined in the edges of the boards.Two breadboards based on these solutions have been developed and demonstrate very good RF performances between 5 and 15 GHz.
Induced Lorentz-violating terms at finite temperature
Creators: name: Leite, J.
name: Mariz, T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the radiatively induced Lorentz-violating terms at finite temperature, namely, the higher-derivative term and the Chern-Simons term. These terms are induced by integrating out the fermions coupled to the coefficient $g^{κμν}$. The calculation of the resulting expressions is performed by using the derivative expansion and the Matsubara formalism. The Chern-Simons terms is nonzero only at finite temperature, whereas the higher-derivative term is finite at zero temperature, however, it goes to zero as the temperature grows to infinity. We also obtain a higher-derivative Chern-Simons term, nevertheless, it vanishes asymptotically.
description: 12 pages, 4 figures, revtex4; v2: EPL version
Expression und klinische Bedeutung mTOR-assoziierter Proteine in Nierenzellkarzinom-Metastasen
Creators: name: Germanishvili, Aslan
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2020
Subjects: subject: Hypernephrom
subject: Zentralnervensystem
subject: Metastase
subject: Proteinstoffwechsel
subject: 616.99461

description: Patienten mit einem metastatischen Nierenzellkarzinom haben eine schlechte Prognose und eine variable Ansprechrate auf verfügbare Therapien. Die Identifikation von Proteinen, die eine gezielte Prognose ermöglichen, ist daher Gegenstand intensiver Forschung. Der mTOR-Signalweg wurde mit der Ansprechrate und der Prognose von Nierenzellkarzinompatienten in Verbindung gebracht. Es konnte gezeigt werden, dass mTOR-Komplexe und deren Effektorproteine sowohl in Primärtumoren als auch in Nierenzellkarzinommetastasen exprimiert sind und die Metastasen im Vergleich zu nicht-neoplastischem Gewebe und dem Primärtumor eine erhöhte Expression zeigen. Es ist bisher allerdings noch unklar, wie sich die Expression von mTOR-Komplexen und ihren Effektorproteinen in kranialen und spinalen Metastasen des Nierenzellkarzinoms darstellt. Das Ziel der vorliegenden Arbeit war daher die Untersuchung der mTOR-Expression und der Expression mTOR-assoziierter Proteine in Nierenzellkarzinommetastasen des zentralen Nervensystems von 28 Patienten. Die Stärke der Expression des Gesamtproteins und des phosphorylierten, aktivierten Proteins von mTOR, p70S6K, 4E-BP1 und Akt wurde anhand des immune reactive-Scores bewertet. Die Gewebeproben wurden anhand der Variablen Geschlecht, Alter, Tumorlokalisation, Nephrektomie und Proliferationsrate gruppiert und die IR-Scores der Gruppen miteinander verglichen. Alle untersuchten Proteine zeigten eine vergleichbare Expression des Gesamtproteins und des phosphorylierten Proteins in den Gewebeproben. Insgesamt betrachtet hatte keine der untersuchten klinischen Variablen einen Einfluss auf die Expression der Proteine in den Metastasen des zentralen Nervensystems. Statistisch signifikante Unterschiede wurden für 4E-BP1 (höhere Expression bei Männern, nach Nephrektomie, und niedrigem MIB-Proliferationsscore, p<0,05) und mTOR (höhere Expression bei Männern, in kranialen Tumoren und ohne Nephrektomie) beobachtet. Die mTOR-assoziierten Proteine waren weiterhin mittels Western blot in Gewebelysaten von Nierenzellkarzinom-Metastasen nachweisbar. Die in vitro-Behandlung der Nierenkarzinomzelllinien Caki-1 und Caki-2 mit dem mTOR-Inhibitor AZD8055 führte zu reduziertem Zellwachstum und verminderter Koloniebildung. Die vorliegende Studie demonstriert, dass der mTOR-Signalweg in Nierenzellkarzinommetastasen des ZNS aktiviert ist, dass jedoch die Expression von mTOR und mTOR-assoziierten Proteinen insgesamt niedrig ist und nicht vom Alter oder dem Geschlecht des Patienten, der Lokalisation der Metastasen, der Proliferationsrate oder vorheriger Nephrektomie abhängig zu sein scheint.
Virtual Hippotherapy for the Treatment of Idiopathic Scoliosis
Creators: name: Rösner, Daniel
name: Brunnett, Guido
name: Israel, Steffen
name: Kaden, Gerd
name: Kehr, Marko
name: Kronfeld, Thomas
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Applied computing
Consumer health
Computing methodologies
Virtual reality
Human centered computing

description: We present a prototype of an integrated virtual reality (VR) system which is intended to supplement traditional therapeutic practices for the conservative treatment of idiopathic scoliosis. Our solution is inspired by equine-assisted therapy (hippotherapy) and includes a horse riding simulator, therapist GUI as well as a synchronized visualization using either a conventional monitor or a head-mounted display (HMD) as an output device. A proof-of-concept study indicates that the system could constitute a valuable addition to the practice of physical therapy.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: Interaction and Applications
description: 53
description: 61
description: Daniel Rösner, Guido Brunnett, Steffen Israel, Gerd Kaden, Marko Kehr, and Thomas Kronfeld
description: CCS Concepts: Applied computing --> Consumer health; Computing methodologies --> Virtual reality; Human-centered computing --> Virtual reality
A Tabletop for the Natural Inspection of Decorative Surfaces
Creators: name: Kindsvater, Anton
name: Eibich, Tom David
name: Weier, Martin
name: Hinkenjann, André
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Human centered computing
Visualization systems and tools
Visualization design and evaluation methods
Computing methodologies
Mixed / augmented reality
Reflectance modeling

description: Designs for decorative surfaces, such as flooring, must cover several square meters to avoid visible repeats. While the use of desktop systems is feasible to support the designer, it is challenging for a non-domain expert to get the right impression of the appearances of surfaces due to limited display sizes and a potentially unnatural interaction with digital designs. At the same time, large-format editing of structure and gloss is becoming increasingly important. Advances in the printing industry allow for more faithful reproduction of such surface details. Unfortunately, existing systems for visualizing surface designs cannot adequately account for gloss, especially for non-domain experts. Here, the complex interaction of light sources and the camera position must be controlled using software controls. As a result, only small parts of the data set can be properly inspected at a time. Also, real-world lighting is not considered here. This work presents a system for the processing and realistic visualization of large decorative surface designs. To this end, we present a tabletop solution that is coupled to a live 360° video feed and a spatial tracking system. This allows for reproducing natural view-dependent effects like real-world reflections, live image-based lighting, and the interaction with the design using virtual light sources employing natural interaction techniques that allow for a more accurate inspection even for non-domain experts.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: Interaction and Applications
description: 63
description: 72
description: Anton Kindsvater, Tom David Eibich, Martin Weier, and André Hinkenjann
description: CCS Concepts: Human-centered computing --> Visualization systems and tools; Visualization design and evaluation methods; Computing methodologies --> Mixed / augmented reality; Reflectance modeling
Analysis of the stabilized supralinear network
Creators: name: Ahmadian, Yashar
name: Rubin, Daniel B.
name: Miller, Kenneth D.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: We study a rate-model neural network composed of excitatory and inhibitory neurons in which neuronal input-output functions are power laws with a power greater than 1, as observed in primary visual cortex. This supralinear input-output function leads to supralinear summation of network responses to multiple inputs for weak inputs. We show that for stronger inputs, which would drive the excitatory subnetwork to instability, the network will dynamically stabilize provided feedback inhibition is sufficiently strong. For a wide range of network and stimulus parameters, this dynamic stabilization yields a transition from supralinear to sublinear summation of network responses to multiple inputs. We compare this to the dynamic stabilization in the "balanced network", which yields only linear behavior. We more exhaustively analyze the 2-dimensional case of 1 excitatory and 1 inhibitory population. We show that in this case dynamic stabilization will occur whenever the determinant of the weight matrix is positive and the inhibitory time constant is sufficiently small, and analyze the conditions for "supersaturation", or decrease of firing rates with increasing stimulus contrast (which represents increasing input firing rates). In work to be presented elsewhere, we have found that this transition from supralinear to sublinear summation can explain a wide variety of nonlinearities in cerebral cortical processing.
description: 45 pages, 4 figures
10 Gbit/s differential amplifier demonstrating striplines in 0.18µm CMOS technology
Creators: name: Milivojevic, B.
name: Gu, Z.
name: Thiede, A.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: We demonstrate the differential amplifier usingstriplines in 0.18µmCMOS technology. A test circuit hassingle-phasegain of 6 dB and 6.2 GHz bandwidth. Eyediagram of the amplifier at 10Gb/s shows good eye opening. Thisgivesthe possibilities for using the strip lines in circuits where over all good shielding is needed.
Revisions to Canada's sentencing regime as a remedy to the over-incarceration of persons with mental disabilities
Creators: name: Aikenhead, Moira
Publisher: name: University of British Columbia
Year: 2014

description: Persons with mental disabilities make up a significant proportion of the prison population in Canada. In addition to being a group that is subject to discrimination and disadvantage generally in this country, individuals with mental disabilities are particularly vulnerable as prisoners and suffer serious adverse consequences from incarceration not experienced by other prisoners. Individuals with mental disabilities are being sent to prison at an increasing rate, despite recognition in the jurisprudence that the presence of a mental disability will in many cases reduce an offender’s moral blameworthiness for her actions. This Thesis explores these issues through a review of social science literature, legal academic writing and jurisprudence. It concludes that an inconsistent application of sentencing principles developed through the common law and increasing implementation of “tough on crime” legislation by Parliament has resulted in many offenders with mental disabilities being sent to prison, despite the fact that in many circumstances alternatives to incarceration would be a more equitable result and better ensure ongoing public safety. The second part of my Thesis proposes potential revisions to the Criminal Code’s sentencing provisions that could assist in combating the problem of over-incarceration of mentally disabled offenders. These proposals include a requirement that sentencing judges must in every circumstance consider the unique circumstances of offenders with mental disabilities, including both the impacts of mental disability on their behaviour and the systemic discrimination faced by this group in a variety of socioeconomic spheres. The second proposal is a legislative exemption to mandatory minimum sentences for offenders with mental disabilities, based on the principle that individualized and proportionate sentences are crucial for these offenders to avoid perpetuating discrimination based on mental disability in the criminal justice system. A final proposed revision would give judges an increased ability to order conditional sentences for this group of offenders, as a counter to the increased legislative limitations on the use of this potentially beneficial sentencing alternative.
Compelling AR Earthquake Simulation with AR Screen Shaking
Creators: name: Chotchaicharin, Setthawut
name: Schirm, Johannes
name: Isoyama, Naoya
name: Monteiro, Diego Vilela
name: Uchiyama, Hideaki
name: Sakata, Nobuchika
name: Kiyokawa, Kiyoshi
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Human centered computing
Mixed / augmented reality
Virtual reality
User studies
Computing methodologies
Real
time simulation

description: Many countries around the world suffer losses from earthquake disasters. To reduce the injury of individuals, safety training is essential to raise people's preparedness. To conduct virtual training, previous work uses virtual reality (VR) to mimic the real world, without considering augmented reality (AR). Our goal is to simulate earthquakes in a familiar environment, for example in one's own office, helping users to take the simulation more seriously.With this approach, we make it possible to flexibly switch between different environments of different sizes, only requiring developers to adjust the furniture layout. We propose an AR earthquake simulation using a video see-through VR headset, then use real earthquake data and implement a novel AR screen shake technique, which simulates the forces applied to the user's head by shaking the entire view. We run a user study (n=25), where participants experienced an earthquake both in a VR scene and two AR scenes with and without the AR screen shake technique. Along with a questionnaire, we collected real-time heart rate and balance information from participants for analysis. Our results suggest that both AR scenes offer a more compelling experience compared to the VR scene, and the AR screen shake improved immediacy and was preferred by most participants. This showed us how virtual safety training can greatly benefit from an AR implementation, motivating us to further explore this approach for the case of earthquakes.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: Feedback and Registration
description: 73
description: 81
description: Setthawut Chotchaicharin, Johannes Schirm, Naoya Isoyama, Diego Vilela Monteiro, Hideaki Uchiyama, Nobuchika Sakata, and Kiyoshi Kiyokawa
description: CCS Concepts: Human-centered computing --> Mixed / augmented reality; Virtual reality; User studies; Computing methodologies --> Real-time simulation
Electrotactile Feedback For Enhancing Contact Information in Virtual Reality
Creators: name: Vizcay, Sebastian
name: Kourtesis, Panagiotis
name: Argelaguet, Ferran
name: Pacchierotti, Claudio
name: Marchal, Maud
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Human centered computing
Haptic devices
Virtual reality
User studies

description: This paper presents a wearable electrotactile feedback system to enhance contact information for mid-air interactions with virtual objects. In particular, we propose the use of electrotactile feedback to render the interpenetration distance between the user's finger and the virtual content is touched. Our approach consists of modulating the perceived intensity (frequency and pulse width modulation) of the electrotactile stimuli according to the registered interpenetration distance. In a user study (N=21), we assessed the performance of four different interpenetration feedback approaches: electrotactile-only, visual-only, electrotactile and visual, and no interpenetration feedback. First, the results showed that contact precision and accuracy were significantly improved when using interpenetration feedback. Second, and more interestingly, there were no significant differences between visual and electrotactile feedback when the calibration was optimized and the user was familiarized with electrotactile feedback. Taken together, these results suggest that electrotactile feedback could be an efficient replacement of visual feedback for enhancing contact information in virtual reality avoiding the need of active visual focus and the rendering of additional visual artefacts.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: Feedback and Registration
description: 83
description: 92
description: Sebastian Vizcay, Panagiotis Kourtesis, Ferran Argelaguet, Claudio Pacchierotti, and Maud Marchal
description: CCS Concepts: Human-centered computing --> Haptic devices; Virtual reality; User studies
Large-signal behavioral model of a packaged RF amplifier based on QPSK-like multisine measurements
Creators: name: Myslinski, Maciej
name: Schreurs, Dominique
name: Remley, Kate A.
name: McKinley, Michael D.
name: Nauwelaers, Bart
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: This work presents a large-signal time-domain behavioral model of an off-the-shelf RF amplifier based on a multisine excitation that emulates a quadrature phase-shift  keyed (QPSK) signal. The multisine has been designed using an automated procedure. As a result, the excitation’s Probability Density Function (PDF) approximates that of a realistic QPSK-modulated digital signal. The model accurately predicts both amplitude and phase of the complex envelope around the carrier as well as higher harmonics.
Reversibility conditions for quantum channels and their applications
Creators: name: Shirokov, M. E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: A necessary condition for reversibility (sufficiency) of a quantum channel with respect to complete families of states with bounded rank is obtained. A full description (up to isometrical equivalence) of all quantum channels reversible with respect to orthogonal and nonorthogonal complete families of pure states is given. Some applications in quantum information theory are considered. The main results can be formulated in terms of the operator algebras theory (as conditions for reversibility of channels between algebras of all bounded operators).
description: 28 pages, this version contains strengthened results of the previous one and of arXiv:1106.3297; to appear in Sbornik: Mathematics, 204:7 (2013)
Transkutane Vagusnervstimulation (tVNS) und die Dynamik visueller bistabiler Wahrnehmung
Creators: name: Beller, Lisa Maria
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2022
Subjects: subject: Visuelle Wahrnehmung
subject: Vagus
subject: Aminobuttersäure gamma-
subject: 612.811

description: Das Phänomen der bistabilen Wahrnehmung beschreibt das Erkennen zweier verschiedener Interpretationsmöglichkeiten beim Betrachten desselben Bildes. Die Fähigkeit zu ebenjener Wahrnehmung wird durch vielfältige Mechanismen im Neurotransmitterhaushalt des primär visuellen Kortex und übergeordneter visueller Zentren bestimmt. Die transkutane Vagusnervstimulation (tVNS) hat, neben zahlreichen weiteren Wirkungsweisen, Einfluss auf die Höhe der GABA-Konzentration. Das primäre Ziel dieser prospektiven Studie im Cross-over-Design war, unsere Hypothese, tVNS verbessere über eine Erhöhung der GABA-Konzentration die Stabilität der bistabilen Wahrnehmung, zu evaluieren. An 35 gesunden Probanden testeten wir jeweils vor und nach tVNS bzw. einer Placebo-Stimulation zwei Perzepte zur bistabilen Wahrnehmung. Darüber hinaus analysierten wir den Einfluss auf die Fähigkeit zur Winkeldiskrimination und untersuchten die VSEPs, eine Möglichkeit die tVNS im EEG sichtbar zu machen, an den jeweiligen Testpersonen. In unserer Studie konnten wir keinen Zusammenhang zwischen der tVNS und der Stabilität der wahrgenommenen Bilder feststellen. Auch bei unseren Tests zur Winkeldiskrimination und der Messung der VSEPs konnten wir keine Parallelen zur tVNS herstellen. Wir konnten lediglich zeigen, dass die Stabilität der unterschiedlichen Perzepte bei den verschiedenen Probanden insgesamt miteinander korrelierten. Das gibt Hinweise auf die komplexen zugrundeliegenden Mechanismen der bistabilen Wahrnehmung und zeigt die bestehenden großen interindividuellen Unterschiede.
Understanding and resolving cultural heritage repatriation disputes between indigenous peoples and museums
Creators: name: Jessiman, Stacey Rae
Publisher: name: University of British Columbia
Year: 2014

description: Disputes between Indigenous peoples and Western museums over repatriation of cultural heritage involve numerous complex issues -- legal, ethical, historical, cultural, spiritual, political and economic, among others – that necessitate a particularly thoughtful approach to resolving such disputes. Resolution of such disputes by negotiation or other alternative dispute resolution (“ADR”) processes should not involve simply finding quick, theoretically “win-win” solutions such as replicas or loans. Because these disputes often involve complex issues such as traumatic colonial injustices and profound differences in cultural values and dispute resolution paradigms, the dispute resolution process must involve a period of exploration and acknowledgement of such issues and differences by the parties, which I term “Relationship Building”, as a necessary precursor to any stage of problem-solving. By analysing the negotiations between various Western museums and the Kwakwaka’wakw and Haisla First Nations of British Columbia, Canada over the repatriation of cultural objects removed from their traditional territories by colonial forces in the early 20th century, this thesis seeks to demonstrate how engaging in a stage of Relationship Building early in the negotiation process is key to ensuring the parties understand their dispute holistically and experience a constructive, not destructive, process and outcome.
The homotopy theory of Khovanov homology
Creators: name: Everitt, Brent
name: Turner, Paul
Publisher: name: arXiv
Year: 2011
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Topology (math.AT)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: We show that the unnormalised Khovanov homology of an oriented link can be identified with the derived functors of the inverse limit. This leads to a homotopy theoretic interpretation of Khovanov homology.
description: 36 pages; reformatted and some minor changes
Immersive Volumetric Point Cloud Manipulation for Cultural Heritage
Creators: name: Drissi, Rafik
name: Gaugne, Ronan
name: Nicolas, Théophane
name: Gouranton, Valérie
Publisher: name: The Eurographics Association
Year: 2021
Subjects: Human centered computing
Virtual reality
Applied computing
Archaeology

description: In this paper, we present a framework for an immersive and interactive 3D manipulation of volumetric point clouds in virtual reality. The framework was designed to meet the needs of cultural heritage experts such as archaeologists or curators for use on cultural heritage artifacts. We propose a display infrastructure associated with a set of tools that allows users from the cultural heritage domain to interact directly with the point clouds within their study process. The resulting framework allows an immersive navigation, interaction and real time segmentation.
description: ICAT-EGVE 2021 - International Conference on Artificial Reality and Telexistence and Eurographics Symposium on Virtual Environments
description: Feedback and Registration
description: 93
description: 97
description: Rafik Drissi, Ronan Gaugne, Théophane Nicolas, and Valérie Gouranton
description: CCS Concepts: Human-centered computing --> Virtual reality; Applied computing --> Archaeology
System-level simulation of a noisy phase-locked loop
Creators: name: Herzel, Frank
name: Piz, Maxim
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: This paper presents a compact model of a noisy phase-locked loop (PLL) for inclusion in a time-domain system simulation. The phase noise of the reference is modeled as a Wiener process, and the phase noise contribution of the voltage-controlled oscillator (VCO) is described as an Ornstein-Uhlenbeck process. The model is applied to phase error modeling for a 60 GHz OFDM system including correction of the common phase error. A close agreement is observed between the time-domain simulation and a frequency-domain model.