cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effectiveness of two silicone dressings for sacral and heel pressure ulcer prevention compared with no dressings in high‐risk intensive care unit patients: a randomized controlled parallel‐group trial
Creators: name: Hahnel, E.
name: El Genedy, M.
name: Tomova‐Simitchieva, T.
name: Hauß, A.
name: Stroux, A.
name: Lechner, A.
name: Richter, C.
name: Akdeniz, M.
name: Blume‐Peytavi, U.
name: Löber, N.
name: Kottner, J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: pressure ulcer
subject: dressings
subject: prevention
subject: silicone
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background There is a high incidence of pressure ulcers in high-risk settings such as intensive care. There is emerging evidence that the application of dressings to pressure ulcer predilection areas (sacrum and heels) improves prevention strategies. Objectives To determine whether preventive dressings, applied to the sacrum and heels of high-risk patients in intensive care units, in addition to standard prevention, reduces the incidence of pressure ulcers. Methods Between June 2015 and July 2018, a randomized, controlled, two-arm, superiority pragmatic study was performed with a concealed 1 : 1 allocation to the intervention and control group. Patients assigned to the intervention group had dressings applied to the sacrum and heels. Results In total, 7575 patients were screened for eligibility and 475 patients were included and allocated to both groups. Finally, 212 patients in the intervention group and 210 in the control group were analysed. The mean age was 63 center dot 5 years and the majority of patients were male (65 center dot 4%). The cumulative pressure ulcer incidence category II and above was 2 center dot 8% in the intervention, and 10 center dot 5% in the control group (P = 0 center dot 001). Compared with the control group, the relative risk in the intervention group was 0 center dot 26 [95% confidence interval (CI) 0 center dot 11-0 center dot 62] and the absolute risk reduction was 0 center dot 08 (95% CI 0 center dot 03-0 center dot 13). Conclusions The results indicate that the application of dressings, in addition to standard prevention, in high-risk intensive care unit patients is effective in preventing pressure ulcers at the heels and sacrum. What's already known about this topic? Pressure ulcers are severe soft tissue injuries and wounds, which occur worldwide in all healthcare settings. Despite preventive interventions, pressure ulcers still develop. There is emerging evidence that dressings help to prevent pressure ulcers. What does this study add? The incidence of pressure ulcers in intensive care units among high-risk patients remains high. The application of dressings to the sacrum and heels, in addition to standard preventive measures, reduces the relative and absolute risks for the development of pressure ulcers. The application of preventive dressings at the heels and sacrum seems to be feasible in intensive care settings.
Geomorphology of the Upper General River Basin, Costa Rica
Creators: name: Quesada-Román, Adolfo
name: Zamorano-Orozco, José Juan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: In spite of the geomorphological diversity of Central America and Costa Rica, there are few detailed geomorphological maps. A 1:25,000 scale map of the Upper General River Basin (UGRB) in Costa Rica is presented, based on the interpretation of aerial photographs and field geomorphological mapping. A total of 43 types of landforms divided genetically into endogenic (tectonic features), and exogenic (fluvial, gravitational, and glacial features) are mapped for an area of 1560 km2. This cartography is important in terms of disaster prevention and mitigation (floods and hillslope processes), as well as for land use planning.
Effectiveness of vaccination against SARS-CoV-2 Omicron variant infection, symptomatic disease, and hospitalization: a systematic review and meta-analysis
Creators: name: Meggiolaro, Angela
name: Schepisi, Monica Sane
name: Farina, Sara
name: Castagna, Carolina
name: Mammone, Alessia
name: Siddu, Andrea
name: Stefanelli, Paola
name: Boccia, Stefania
name: Rezza, Giovanni
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: This meta-analysis aims to assess the effectiveness of the current Sars-Cov2 vaccine regimens against Omicron infection. A secondary endpoint aims to investigate the waning effectiveness of primary vaccination against symptomatic infection and related hospitalization. The systematic review started on 1 December 2021 and was concluded on 1 March 2022. Random-effects frequentist meta-analyses and multiple meta-regressions were performed. In total, 15 studies are included in the quantitative synthesis. According to the meta-analysis results, the overall risk of Sars-Cov2 infection in vaccinated individuals is on average 31 · 5% lower than the infection risk in unvaccinated while vaccinated with one booster dose have a 70 · 4% risk reduction of Omicron infection compared to unvaccinated. In particular, one booster dose significantly decreases by 69% the risk of symptomatic Omicron infection with respect to unvaccinated. Six months after the primary vaccination, the average risk reduction declines to 22% against symptomatic infection and to 55% against hospitalization. Primary vaccination does not provide sufficient protection against symptomatic Omicron infection. Although the effectiveness of the primary vaccination against hospitalization due to Omicron remains significantly above 50% after 3 months, it dramatically fades after 6 months.
title: Νέα δημοτική και παιδική βιλβιοθήκη Χανίων
title: New municipal and children's library of Chania
Creators: name: Μπενακη Μαρκελα
Publisher: name: Technical University of Crete
Year: 2023

description: Η παρούσα διπλωματική εργασία έχει ως στόχο την δημιουργία Νέας Δημοτικής και παιδικής βιβλιοθήκης για τον Δήμο Χανιών. Συγκεκριμένα, η νέα βιβλιοθήκη τοποθετείται στην  δημοτική ενότητα του αγίου Ιωάννη στα Χανιά ανάμεσα στην περιοχή των Δικαστηρίων Χανίων και στο τέως στρατόπεδο Μαρκοπούλου. Το οικόπεδο επέμβασης βλέπει ως κύριο δρόμο την οδό Γιαμπουδάκη και μέχρι πρότινος αποτελούσε ανεκμετάλλευτο πάρκο γειτονιάς. Όμορο της περιοχής επέμβασης είναι το 8ο δημοτικό σχολείο και 4ο νηπιαγωγείο χανιών. Αξιοσημείωτο γεγονός αποτελεί ότι δεν υπήρχε καμία άμεση πρόσβαση από το σχολείο προς το πάρκο ούτε και προοπτική εκμετάλλευσής του για χρήσεις του σχολείου. Για τον σχεδιασμό της νέας δημοτικής βιβλιοθήκης προτείνεται η επέκταση του σχολείου και η ενοποίηση του με τον χώρο της παιδικής βιβλιοθήκης και την άμεση σύνδεση αυτών. Η τοποθέτηση της δημοτικής βιβλιοθήκης στην περιοχή αυτή αποσκοπεί στον εμπλουτισμό των πολιτιστικών χρήσεων και ενίσχυση ενός από τους πυρήνες της πόλης δηλαδή την περιοχή των δικαστηρίων και το τέως στρατόπεδο Μαρκοπούλου.
description: This thesis aims to create a new municipal and children's library for the Municipality of Chania. Specifically, the new library is located in the municipal unit of Agios Ioannis in Chania between the area of the Chania Courts and the former camp of Markopoulou. The intervention plot faces the main road Yamboudaki Street and until recently was an unused neighborhood park. Bordering the intervention area is the 8th primary school and 4th kindergarten of Chania. It is notable that there was no direct access from the school to the park and no prospect of its exploitation for school purposes. For the design of the new public library it is proposed to extend the school and integrate it with the children's library area and directly connect them. The placement of the public library in this area is intended to enrich the cultural uses and strengthen one of the city's cores namely the area of the courts and the former Markopoulou camp.
Statistically validated networks in bipartite complex systems
Creators: name: Tumminello, Michele
name: Miccichè, Salvatore
name: Lillo, Fabrizio
name: Piilo, Jyrki
name: Mantegna, Rosario N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Many complex systems present an intrinsic bipartite nature and are often described and modeled in terms of networks [1-5]. Examples include movies and actors [1, 2, 4], authors and scientific papers [6-9], email accounts and emails [10], plants and animals that pollinate them [11, 12]. Bipartite networks are often very heterogeneous in the number of relationships that the elements of one set establish with the elements of the other set. When one constructs a projected network with nodes from only one set, the system heterogeneity makes it very difficult to identify preferential links between the elements. Here we introduce an unsupervised method to statistically validate each link of the projected network against a null hypothesis taking into account the heterogeneity of the system. We apply our method to three different systems, namely the set of clusters of orthologous genes (COG) in completely sequenced genomes [13, 14], a set of daily returns of 500 US financial stocks, and the set of world movies of the IMDb database [15]. In all these systems, both different in size and level of heterogeneity, we find that our method is able to detect network structures which are informative about the system and are not simply expression of its heterogeneity. Specifically, our method (i) identifies the preferential relationships between the elements, (ii) naturally highlights the clustered structure of investigated systems, and (iii) allows to classify links according to the type of statistically validated relationships between the connected nodes.
description: Main text: 13 pages, 3 figures, and 1 Table. Supplementary information: 15 pages, 3 figures, and 2 Tables
An analysis of the blue straggler population in the Sgr dSph globular cluster Arp 2
Creators: name: Carraro, Giovanni
name: Seleznev, Anton F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present and discuss new BVI CCD photometry in the field of the globular cluster Arp~2, which is considered a member of the Sagittarius Dwarf Spheroidal Galaxy. The main goal of this investigation is to study of the statistics and spatial distribution of blue straggler stars in the cluster. Blue stragglers are stars observed to be hotter and bluer than other stars with the same luminosity in their environment. As such, they appear to be much younger than the rest of the stellar population. Two main channels have been suggested to produce such stars: (1) collisions between stars in clusters or (2) mass transfer between, or merger of, the components of primordial short-period binaries. The spatial distribution of these stars inside a star cluster, compared with the distribution of stars in different evolutionary stages, can cast light on the most efficient production mechanism at work. In the case of Arp~2, we found that blue straggler stars are significantly more concentrated than main sequence stars, while they show the same degree of concentration as evolved stars (either red giants or horizontal branch stars). Since Arp~2 is not a very concentrated cluster, we suggest that this high central concentration is an indication that blue stragglers are mostly primordial binary stars.
description: 6 pages, 9 figures, in press in MNRAS
Hopes and Hurdles of Employing Mesenchymal Stromal Cells in the Treatment of Cardiac Fibrosis
Creators: name: Neuber, Sebastian
name: Emmert, Maximilian Y.
name: Nazari-Shafti, Timo Z.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: cardiac fibrosis
subject: heart failure
subject: mesenchymal stromal cells
subject: therapy
subject: anti-fibrosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Excessive cardiac fibrosis plays a crucial role in almost all types of heart disease. Generally, cardiac fibrosis is a scarring process triggered in response to stress, injury, or aging and is characterized by the accumulation of activated myofibroblasts that deposit high levels of extracellular matrix proteins in the myocardium. While it is beneficial for cardiac repair in the short term, it can also result in pathological remodeling, tissue stiffening, and cardiac dysfunction, contributing to the progression of heart failure, arrhythmia, and sudden cardiac death. Despite its high prevalence, there is a lack of effective and safe therapies that specifically target myofibroblasts to inhibit or even reverse pathological cardiac fibrosis. In the past few decades, cell therapy has been under continuous evaluation as a potential treatment strategy, and several studies have shown that transplantation of mesenchymal stromal cells (MSCs) can reduce cardiac fibrosis and improve heart function. Mechanistically, it is believed that the heart benefits from MSC therapy by stimulating innate anti-fibrotic and regenerative reactions. The mechanisms of action include paracrine signaling and cell-to-cell interactions. In this review, we provide an overview of the anti-fibrotic properties of MSCs and approaches to enhance them and discuss future directions of MSCs for the treatment of cardiac fibrosis.
Geomorphology of the Sierra del Aramo (Asturian Central Massif, Cantabrian Mountains, NW Spain)
Creators: name: Bergua, Salvador Beato
name: Piedrabuena, Miguel Ángel Poblete
name: Pérez, Carmen Rodríguez
name: Alfonso, José Luis Marino
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: A detailed geomorphological map of the Sierra del Aramo (Asturian Central Massif) is presented at a scale of 1:25,000. The Sierra del Aramo is one of the major middle-altitude mountains of the Asturian Central Massif (maximum altitude 1,791 m a.s.l.). Specifically, the lithology and the structural landforms, as well as karst, fluvial, periglacial and other landforms and deposits, have been mapped based on meticulous fieldwork, photointerpretation and a geographic information system. The final printing has been drawn carefully following the RCP 77 geomorphological mapping system of the French CNRS to achieve a graphic design that adequately expresses the true nature of the landforms. Thus, the geomorphological map is a precise scientific tool that serves as a basis for geoheritage studies, and the analysis of natural hazards; in short, for territorial planning.
Humoral Immune Response following SARS-CoV-2 Vaccination in Liver Transplant Recipients
Creators: name: Timmermann, Lea
name: Globke, Brigitta
name: Lurje, Georg
name: Schmelzle, Moritz
name: Schöning, Wenzel
name: Öllinger, Robert
name: Pratschke, Johann
name: Eberspächer, Bettina
name: Drosten, Christian
name: Hofmann, Jörg
name: Eurich, Dennis
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: liver transplantation
subject: anti-SARS-CoV-2-antibodies
subject: COVID-19
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: As COVID-19 remains an issue in transplantation medicine, a successful vaccination can prevent infections and life-threatening courses. The probability of poor immune response in liver transplant recipients gained attention and insecurity among those patients, leading us to investigate the humoral immune response alongside the influence of underlying diseases and immunosuppressive regimen on seroconversion rates. We included 118 patients undergoing anti-spike-protein-IgG testing at least 21 days after completed SARS-CoV-2 vaccination. Ninety-seven patients also underwent anti-spike-protein-IgA testing. The influence of baseline demographics, immunosuppressive regimen and underlying disease on seroconversion was analyzed, and 92 of 118 patients (78.0%) developed anti-spike-protein-IgG antibodies. Patients with a history of alcoholic liver disease before transplantation showed significantly lower seroconversion rates (p = 0.006). Immunosuppression also significantly influenced antibody development (p < 0.001). Patients run on a mycophenolate mofetil (MMF)-based regimen were more likely not to develop antibodies compared to patients run on a non-MMF regimen (p < 0.001). All patients weaned off immunosuppression were seropositive. The seroconversion rate of 78.0% in our cohort of liver transplant recipients is promising. The identification of alcohol-induced cirrhosis as underlying disease and MMF for immunosuppression as risk factors for seronegativity may serve to identify vaccination non-responder after liver transplantation.
On probing the properties of QSOs through their proximity effects on the intergalactic medium
Creators: name: Lu, Youjun
name: Yu, Qingjuan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The proximity effect (PE) of QSOs is believed to be useful in constraining the QSO lifetime. Observations on the PE so far, however, give apparently contradictory results -- some are consistent with a long QSO lifetime (>~ a few 10^7 yr), but others appear to be only consistent with a short QSO lifetime
description: 14 pages, 11 figures, to appear in ApJ
The Nansen Initiative and the development of an international protection norm for cross-border disaster-displaced persons
Creators: name: Okeowo, Ademola Oladimeji
Publisher: name: University of British Columbia
Year: 2018

description: Using the Nansen Initiative on Disaster-Induced Cross-Border Displacement (the “Nansen Initiative”) as a case study, this dissertation applies a synthesis of the theories of international norm development to the decades of international efforts for the recognition and protection of cross-border disaster-displaced persons leading to the establishment of the Nansen Initiative in 2012. The dissertation examines the range of guideposts in the international norms literature for identifying a successful new norm. Relying on judicial precedents and some notable literature on international norms, this dissertation argues that there are diverse forms of contemporary international law. Thus, the dissertation concludes that the Protection Agenda, which is the final product of the work of the Nansen Initiative, is a normative soft law instrument. The dissertation further examines international norm compliance theories as they might relate to states’ disposition towards the Protection Agenda. Based on the endorsement of the Protection Agenda by 109 states in Geneva in 2015, the calibre of states that made the endorsement, and the enthusiasm with which they did so, the dissertation argues that states are likely to implement it. This is so, given that the establishment of the Platform on Disaster Displacement as a post-Nansen Initiative process for the Agenda’s dissemination, interpretation and implementation purposes is a core requirement in the literature for achieving international norm compliance.
Large-spin asymptotics of Euclidean LQG flat-space wavefunctions
Creators: name: Mikovic, Aleksandar
name: Vojinovic, Marko
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We analyze the large-spin asymptotics of a class of spin-network wavefunctions of Euclidean Loop Quantum Gravity, which corresponds to a flat spacetime. A wavefunction from this class can be represented as a sum over the spins of an amplitude for a spin network whose graph is a composition of the the wavefunction spin network graph with the dual one-complex graph and the tetrahedron graphs for a triangulation of the spatial 3-manifold. This spin-network amplitude can be represented as a product of 6j symbols, which is then used to find the large-spin asymptotics of the wavefunction. By using the Laplace method we show that the large-spin asymptotics is given by a sum of Gaussian functions. However, these Gaussian functions are not of the type which gives the correct graviton propagator.
Temperature and Field Dependence of the Mobility of Highly-Ordered Conjugated Polymer Films
Creators: name: Martin, S. J.
name: Kambili, Agapi
name: Walker, A.
Publisher: name: Universität Regensburg
Year: 2003
Subjects: subject: 530 Physik

description: The transport properties of organic light-emitting diodes in which the emissive layer is composed of highly ordered conjugated polymers have been investigated. We have performed simulations of the current transient response to an illumination pulse via the Monte Carlo approach, and from the transit times we have extracted the mobility of the charge carriers as a function of both the electric field and the temperature. The transport properties of such films are different from their disordered counterparts, with charge carrier mobilities exhibiting only a weak dependence on both the electric field and temperature. We show that for spatially ordered polymer films, this weak dependence arises for thermal energy being comparable to the energetic disorder, due to the combined effect of the electrostatic and thermal energies. The inclusion of spatial disorder, on the other hand, does not alter the qualitative behavior of the mobility, but results in decreasing its absolute value.
Cooling of mechanical motion with a two level system: the high temperature regime
Creators: name: Rabl, P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We analyze cooling of a nano-mechanical resonator coupled to a dissipative solid state two level system focusing on the regime of high initial temperatures. We derive an effective Fokker-Planck equation for the mechanical mode which accounts for saturation and other non-linear effects and allows us to study the cooling dynamics of the resonator mode for arbitrary occupation numbers. We find a degrading of the cooling rates and eventually a breakdown of cooling at very high initial temperatures and discuss the dependence of these effects on various system parameters. Our results apply to most solid state systems which have been proposed for cooling a mechanical resonator including quantum dots, superconducting qubits and electronic spin qubits.
31915: Working from home
Creators: name: Project, Lockdown2020 and Beyond
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 479999
subject: Other language, communication and culture not elsewhere classified

description: I have been working from home since mid March 2020. I took the decision to do this before the countrywide lock down in late March and was allowed to do so. On work days I wake up around 7.30am, I no longer have get up so early to commute into the office. I tune in to the news headlines using the BBC Sounds app on my phone, drink some coffee and get ready to start the day. I check in remotely my the rest of my team at around 9am. I might have meetings via Zoom or Teams with colleagues in the same organisation. Otherwise I am focused on doing my work remotely, not travelling in to the office has not affected my work too greatly. I keep in touch with colleagues via Slack, IRC or Teams, and we often share photos of how our days are going. At noon I take my lunch break for an hour, we have online grocery deliveries, so I normally reheat something that I've made earlier from our recipe box. Whilst eating I usually watch some of the national news, which tends to be the Scottish Government's daily press briefing (on all news channels just after 12) and then switch to something more diverting on BBC iPlayer or Netflix. My afternoon working pattern is similar to the morning. I finish work around 5pm, at which time I will check the news online and then either do some online training (I am trying to learn some new skills), or do some indoor exercise or yoga using an app on my phone. When my partner also finishes work for the day, we go for a walk close to our home (the government allows us 1 hour of our door exercise per day). Some evenings we also chat with friends or family via WhatsApp or FaceTime video chat. Almost every evening we will cook something from our recipe box and watch some TV. After that it's normally time to load the dishwasher, make some coffee for the morning, go to bed and prepare to do the same again tomorrow.
The value of public-private collaborative real-world evidence platforms to monitor vaccine performance post authorization: DRIVE - a European initiative
Creators: name: Díez-Domingo, Javier
name: Torcel-Pagnon, Laurence
name: Carmona, Antonio
name: Launay, Odile
name: Dos Santos, Gaël
name: Rizzo, Caterina
name: Haag, Mendel
name: Stuurman, Anke
name: Nauta, Jos
name: Vannacci, Alfredo
name: de Lusignan, Simon
name: Del Rey, Elena
name: Levi, Miriam
name: Lina, Bruno
name: Bellino, Stefania
name: Nye, Samantha
name: Neels, Pieter
name: Nohynek, Hanna
name: Mahé, Cédric
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Fighting pandemics requires an established infrastructure for pandemic preparedness, with existing, sustainable platforms ready to be activated. This includes platforms for disease surveillance, virus circulation, and vaccine performance monitoring based on Real-World data, to complement clinical trial evidence. Because of its complexity, this can best be done by combining efforts between public and private sectors, developing a multi-stakeholder approach. Public-Private-Partnerships increasingly play a critical role in combating infectious diseases but are still looked at with hesitancy. The Development of Robust and Innovative Vaccine Effectiveness (DRIVE) project, which established a platform for measuring brand-specific influenza vaccine effectiveness in Europe, exemplifies how to build a collaborative platform with transparent governance, state-of-the-art methodology, and a large network of participating sites. Lessons learned from DRIVE have been cardinal to set up COVIDRIVE, a platform for brand-specific COVID-19 vaccine effectiveness monitoring. The DRIVE partners propose that a debate on the benefits of Public-Private-Partnership-generated real-world evidence for vaccine effectiveness monitoring should be pursued to clarify roles and responsibilities, set up expectations, and decide the future environment for vaccine monitoring in Europe. In parallel, the driving factors behind PPP hesitancy should be studied.
Ustekinumab for the treatment of moderate‐to‐severe plaque psoriasis in paediatric patients (≥ 6 to < 12 years of age): efficacy, safety, pharmacokinetic and biomarker results from the open‐label CADMUS Jr study
Creators: name: Philipp, S.
name: Menter, A.
name: Nikkels, A.F.
name: Barber, K.
name: Landells, I.
name: Eichenfield, L.F.
name: Song, M.
name: Randazzo, B.
name: Li, S.
name: Hsu, M.‐C.
name: Zhu, Y.
name: DePrimo, S.
name: Paller, A.S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: CADMUS Jr
subject: ustekinumab
subject: paediatric psoriasis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Limited options are available for treatment of paediatric psoriasis. Objectives To evaluate the efficacy and safety of ustekinumab in paediatric patients with psoriasis (>= 6 to < 12 years of age). Methods CADMUS Jr, a phase III, open-label, single-arm, multicentre study, evaluated ustekinumab in paediatric patients with moderate-to-severe plaque psoriasis. Patients received weight-based dosing of ustekinumab (< 60 kg: 0 center dot 75 mg kg(-1); >= 60 to <= 100 kg: 45 mg; > 100 kg: 90 mg) administered by subcutaneous injection at weeks 0 and 4, then every 12 weeks through week 40. Study endpoints (all at week 12) included the proportions of patients achieving a Physician's Global Assessment score of cleared/minimal (PGA 0/1) and >= 75%/90% improvement in Psoriasis Area and Severity Index (PASI 75/90), and change in Children's Dermatology Life Quality Index (CDLQI). Serum ustekinumab concentrations, antidrug antibodies and cytokine levels were measured through week 52. Safety was evaluated through week 56. Results In total, 44 patients (median age 9 center dot 5 years) received at least one dose of ustekinumab. Three patients discontinued the study agent through week 40. At week 12, 77% of patients achieved PGA 0/1, 84% achieved PASI 75 and 64% achieved PASI 90 response. The mean change in CDLQI was -6 center dot 3. Trough serum ustekinumab concentrations reached steady state at weeks 28-52. The incidence of antidrug antibodies was 10% (n = 4). Mean serum concentrations of interleukin-17A/F and interleukin-22 were significantly reduced at weeks 12 and 52. Overall, 34 patients (77%) had at least one adverse event and three (7%) had a serious adverse event. Conclusions Ustekinumab effectively treated moderate-to-severe psoriasis in paediatric patients, and no new safety concerns were identified. What is already known about this topic? Ustekinumab is approved for use in adolescents (>= 12 to < 18 years of age) and adults (>= 18 years) with moderate-to-severe psoriasis. What does this study add? Ustekinumab effectively treats moderate-to-severe psoriasis in paediatric patients (>= 6 to < 12 years of age), with no new safety concerns.
title: Non-native sentence processing: a focus on agreement and reflexives
Creators: name: Alaskar, Shatha
Publisher: name: University of Reading
Year: 2024

description: An ongoing debate revolves around whether non-native (L2) speakers resolve
discontinuous linguistic dependencies, such as subject-verb agreement and reflexive 
dependencies, similarly to native (L1) speakers. Variable findings across studies have contributed 
to this ongoing discussion. Among the different factors suggested to explain potential L1/L2 
processing differences, is the role that the working memory retrieval mechanism, which subserves 
dependency processing, may play in L2 processing. While effects associated with this retrieval 
mechanism, namely similarity-based interference effects, have been extensively investigated in 
L1 processing, their relevance to L2 processing remains speculative.
The question of whether the computation of subject-verb agreement and reflexive
dependencies relies on the same memory retrieval mechanism has also been a subject of debate
in the L1 processing literature. This thesis aims to examine these two dependencies, subject-verb 
agreement and reflexive-antecedent dependencies, in parallel experimental settings within the 
same group of participants at different proficiency levels. This approach offers a valuable means
to understand L2 processing patterns across dependencies and brings us closer to reaching a
general agreement on L1/L2 processing similarities and differences, while minimizing individual 
variation.
Through two large-scale studies employing offline and online measures, the results
generally indicated that L2 speakers’ processing patterns are largely similar to those of L1 
speakers. L2 speakers demonstarted sensitivity to grammatical constraints without an increased 
vulnerability to interference effects compared to L1 speakers. Reduced grammaticality effects,
however, were observed specifically for S-V agreement in L2 speakers, while no such attenuation 
was found for reflexive-antecedent dependencies when compared to L1 speakers. Proficiency analysis revealed that this discrepancy may be driven by the performance of lower proficiency L2 
speakers in S-V agreement, contradicting the more target-like processing profile observed in
higher proficiency L2 speakers.
Taken together, the overall pattern of results suggests that L1/L2 processing follows a 
similar manner, and any potential quantitative differences can be attributed to individual 
differences, particularly in L2 proficiency.
The Bank Vole (Clethrionomys glareolus) - Small Animal Model for Hepacivirus Infection
Creators: name: Röhrs, Susanne
name: Begeman, Lineke
name: Straub, Beate K.
name: Boadella, Mariana
name: Hanke, Dennis
name: Wernike, Kerstin
name: Drewes, Stephan
name: Hoffmann, Bernd
name: Keller, Markus
name: Drexler, Jan Felix
name: Drosten, Christian
name: Höper, Dirk
name: Kuiken, Thijs
name: Ulrich, Rainer G.
name: Beer, Martin
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: animal model
subject: virus–host interaction
subject: rodent hepacivirus
subject: bank vole
subject: hepatitis C virus
subject: Hepacivirus F
subject: Hepacivirus J
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health care systems worldwide. Improved small animal models would support further hepacivirus research, including development of vaccines and novel antivirals. The recent discovery of several mammalian hepaciviruses may facilitate such research. In this study, we demonstrated that bank voles (Clethrionomys glareolus) were susceptible to bank vole-associated Hepacivirus F and Hepacivirus J strains, based on the detection of hepaciviral RNA in 52 of 55 experimentally inoculated voles. In contrast, interferon α/β receptor deficient C57/Bl6 mice were resistant to infection with both bank vole hepaciviruses (BvHVs). The highest viral genome loads in infected voles were detected in the liver, and viral RNA was visualized by in situ hybridization in hepatocytes, confirming a marked hepatotropism. Furthermore, liver lesions in infected voles resembled those of HCV infection in humans. In conclusion, infection with both BvHVs in their natural hosts shares striking similarities to HCV infection in humans and may represent promising small animal models for this important human disease.
A Simplification of a Real-Time Verification Problem
Creators: name: Saha, Indranil
name: Misra, Janardan
name: Roy, Suman
Publisher: name: arXiv
Year: 2010
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences
subject: D.2.4; C.2.2
subject: 68Q60

description: We revisit the problem of real-time verification with dense dynamics using timeout and calendar based models and simplify this to a finite state verification problem. To overcome the complexity of verification of real-time systems with dense dynamics, Dutertre and Sorea, proposed timeout and calender based transition systems to model the behavior of real-time systems and verified safety properties using k-induction in association with bounded model checking. In this work, we introduce a specification formalism for these models in terms of Timeout Transition Diagrams and capture their behavior in terms of semantics of Timed Transition Systems. Further, we discuss a technique, which reduces the problem of verification of qualitative temporal properties on infinite state space of (a large fragment of) these timeout and calender based transition systems into that on clockless finite state models through a two-step process comprising of digitization and canonical finitary reduction. This technique enables us to verify safety invariants for real-time systems using finite state model-checking avoiding the complexity of infinite state (bounded) model checking and scale up models without applying techniques from induction based proof methodology. Moreover, we can verify liveness properties for real-time systems, which is not possible by using induction with infinite state model checkers. We present examples of Fischer's Protocol, Train-Gate Controller, and TTA start-up algorithm to illustrate how such an approach can be efficiently used for verifying safety, liveness, and timeliness properties specified in LTL using finite state model checkers like SAL-smc and Spin. We also demonstrate how advanced modeling concepts like inter-process scheduling, priorities, interrupts, urgent and committed location can be specified as extensions of the proposed specification formalism.
description: 32 Pages, 6 Figures. A preliminary version of this draft appeared in the proceedings of ATVA 2007
Real-world impact and effectiveness of the quadrivalent HPV vaccine: an updated systematic literature review
Creators: name: Wang, Wei
name: Kothari, Smita
name: Skufca, Jozica
name: Giuliano, Anna R.
name: Sundström, Karin
name: Nygård, Mari
name: Koro, Carol
name: Baay, Marc
name: Verstraeten, Thomas
name: Luxembourg, Alain
name: Saah, Alfred J.
name: Garland, Suzanne M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Human papillomavirus (HPV) infection, which poses significant disease burden, is decreasing following implementation of vaccination programs. Synthesized evidence on HPV vaccine real-world benefit was published in 2016. However, long-term impact of vaccination, and how vaccination programs influence infection rates and disease outcomes, requires further examination. We systematically reviewed observational studies on HPV vaccination within MEDLINE, EMBASE, and Google Scholar from 2016 to 2020, involving 14 years of follow-up data. We identified 138 peer-reviewed publications reporting HPV vaccine impact or effectiveness. Outcomes of interest included rates of infection at different anatomical sites and incidence of several HPV-related disease endpoints. The expansion of HPV vaccination programs worldwide has led to a reduction in genital infection and significant decreases in incidence of HPV-related disease outcomes. Therefore, the WHO has set goals for the elimination of cervical cancer as a public health concern. To track progress toward this requires an understanding of the effectiveness of different vaccination initiatives. However, the impact on males, and potential benefit of gender-neutral vaccination programs have not been fully explored. To present an accurate commentary on the current outlook of vaccination and to help shape policy therefore requires a systematic review of available data.
Of Animal Husbandry and Food Production - A First Step towards a Modular Agent-Based Modelling Platform for Socio-Ecological Dynamics
Creators: name: Günther, Gerrit
name: Clemen, Thomas
name: Duttmann, Rainer
name: Schütt, Brigitta
name: Knitter, Daniel
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: multi-agent-simulation
subject: pastoralism
subject: human impact
subject: grazing
subject: landscape
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Agent-based models provide detailed, bottom-up approaches to investigate complex socio-ecological systems. This study presents a first step towards a modular agent-based simulation that is based upon empirical data, as well as environmental suitability maps and an assessment of livestock units. To illustrate the capabilities of our simulation, we use a geographically explicit approach to simulate a component of the production of animal products of a rural settlement in the lower Bakırçay catchment, western Turkey. The model structurally couples various agent types representing several elements and processes of the animal husbandry and food production value chain, such as sedentary herders—practising daily, short-distance pastoralism - and their flocks of goats and sheep, as well as milking and slaughtering. The modelling tool captures the fundamental socio-ecological dynamics of animal husbandry and food production in rural settlements. Therefore, the tool is valuable as a basis to discuss hypotheses regarding the number of animals that are needed to cover the requirements of different growing populations.
Effects of non-uniform interstellar magnetic field on synchrotron X-ray and inverse-Compton gamma-ray morphology of SNRs
Creators: name: Orlando, S.
name: Petruk, O.
name: Bocchino, F.
name: Miceli, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Observations of SNRs in X-ray and gamma-ray bands promise to contribute with important information in our understanding on the nature of galactic cosmic rays. The analysis of SNRs images collected in different energy bands requires the support of theoretical modeling of synchrotron and inverse Compton (IC) emission. We develop a numerical code (REMLIGHT) to synthesize, from MHD simulations, the synchrotron radio, X-ray and IC gamma-ray emission from SNRs expanding in non-uniform interstellar medium (ISM) and/or non-uniform interstellar magnetic field (ISMF). As a first application, the code is used to investigate the effects of non-uniform ISMF on the SNR morphology in the non-thermal X-ray and gamma-ray bands. We perform 3D MHD simulations of a spherical SNR shock expanding through a magnetized ISM with a gradient of ambient magnetic field strength. The model includes an approximate treatment of upstream magnetic field amplification and the effect of shock modification due to back reaction of accelerated cosmic rays. From the simulations, we synthesize the synchrotron radio, X-ray and IC gamma-ray emission with REMLIGHT, making different assumptions about the details of acceleration and injection of relativistic electrons. A gradient of the ambient magnetic field strength induces asymmetric morphologies in radio, X-ray and gamma-ray bands independently from the model of electron injection if the gradient has a component perpendicular to the line-of-sight. The degree of asymmetry of the remnant morphology depends on the details of the electron injection and acceleration and is different in the radio, X-ray, and gamma-ray bands. The non-thermal X-ray morphology is the most sensitive to the gradient, showing the highest degree of asymmetry. The IC gamma-ray emission is weakly sensitive to the non-uniform ISMF, the degree of asymmetry of the SNR morphology being the lowest in this band.
description: 16 pages, 13 Figures; accepted for publication on A&A. Version with full resolution images can be found at http://www.astropa.unipa.it/~orlando/PREPRINTS/sorlando_15505.pdf
Inter-process communication in disaggregated datacenters
Creators: name: Carbonari, Amanda
Publisher: name: University of British Columbia
Year: 2018

description: Disaggregation is a promising new datacenter (DC) architecture which aims to mit- igate mounting DC costs. Disaggregated datacenters (DDCs) disaggregate tradi- tional server components into distinct resources. Disaggregation also poses an interesting paradigm shift. Namely, a DDC possesses traits akin to a distributed system, as resources no longer fate-share: a CPU can fail independently of another CPU. It is not unreasonable to assume that these disaggregated resources will still be presented to a user as a single machine. This requirement has implications for disaggregated system design. For example, what happens if a CPU fails during a remote cross-processor procedure call? This is not a new question, as distributed systems, multi-processor systems, and high performance computing (HPC) systems, have grappled with this challenge. We look at how this challenge translates to a disaggregated context, in particular, focusing on the remote procedure call (RPC) abstraction. We design a disaggregated system, Bifröst, to ensure exactly-once semantics for procedure calls under failure scenarios and provide strict memory consistency. We analyze the overhead of Bifröst compared to an equivalent RPC implementation in Thrift. Although, we find that Bifröst has a higher overhead than Thrift, its results are still promising, showing that we can achieve greater functionality than Thrift with a slightly higher overhead.
Nuclear structure study of 19,20,21N nuclei by gamma spectroscopy
Creators: name: Elekes, Z.
name: Vajta, Zs.
name: Dombradi, Zs.
name: Aiba, T.
name: Aoi, N.
name: Baba, H.
name: Bemmerer, D.
name: Fulop, Zs.
name: Iwasa, N.
name: Kiss, A.
name: Kobayashi, T.
name: Kondo, Y.
name: Motobayashi, T.
name: Nakabayashi, T.
name: Nannichi, T.
name: Sakurai, H.
name: Sohler, D.
name: Takeuchi, S.
name: Tanaka, K.
name: Togano, Y.
name: Yamada, K.
name: Yamaguchi, M.
name: Yoneda, K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The structure of neutron rich nitrogen nuclei has been studied by use of neutron removal reaction and inelastic scattering. Mass and charge deformations have been deduced for the first excited state of 21N, which indicates the partial persitence of the N=14 subshell closure in nitrogen isotopes. The spectroscopic information obtained on the structure of 19,20,21N confirms the results from a previous experiment.
The composite Sierra Bermeja Pluton (southern Iberian Massif): science, heritage and geoconservation
Creators: name: Errandonea-Martin, Jon
name: Sarrionandia, Fernando
name: Junguitu, Josu
name: Carracedo-Sánchez, Manuel
name: Eguíluz, Luis
name: Ibarguchi, José Ignacio Gil
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences

description: The Sierra Bermeja Pluton (∼60 km2 surface area) exemplifies a type of controversial granites of the Iberian Massif (European Variscan Belt), the cordierite-bearing ‘Serie Mixta’ (mixed series) monzogranites. The pluton is included almost completely in the Cornalvo Natural Park (Badajoz, Spain), a relevant target area in Roman times. The geological mapping summarised in the presented map at 1:10,000 scale has revealed a complex intrusive assemblage. Three main cordierite-bearing monzogranite types that show local varieties constitute most of the massif. Monzogranite intrusions are younger towards the centre of the pluton and gave rise to outstanding mappable mingling/mixing zones in some areas. A NE–SW trending reduced dyke complex composed by vaugnerite series rocks, lamprophyres, aplites and quartz dykes, completes the lithological assemblage of the pluton. An inventory of Geologic Points of Interest to promote the geological knowledge of this remarkable protected area and its geoconservation is also presented.