cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanical characterisation of freeze-dried biopharmaceuticals
Creators: name: McCartney, Sharmila
Publisher: name: Imperial College London
Year: 2014

description: This thesis presents comprehensive investigations into the mechanical behaviour of freeze dried (FD) biopharmaceuticals with respect to processing conditions (freezing rate, mode of ice nucleation and primary drying temperature). The contribution of formulation composition, cake density and individual excipients on the mechanical properties were studied. The interactive effect of processing conditions and model formulation composition was also studied using statistically designed experiments. A mechanical indentation test using a flat faced punch was developed and validated to test fragile freeze-dried cakes in-situ (within vial) without any sample preparation. FD cakes were made from sucrose, trehalose, mannitol and model formulations with lysozyme and bovine serum albumin (BSA) under typical industrial FD process conditions. Freeze-dried cakes exhibited failure by a brittle crushing mechanism. An initial near linear rise in the stress-strain curve represented cake elastic behaviour and transitioned into a steady stress plateau as strain was increased, with intermittent cracking and crushing failures representative of cells failures in the z axial direction. FD trehalose, sucrose and mannitol have distinctly different Young’s modulus and maximum stresses at failure. Higher primary drying temperature (-40°C) causes cell micro-collapse hence reduces the Young’s modulus and crushing stress compared to -50°C. Cakes manufactured at faster cooling rates (0.9°C/min) produce smaller pore sizes but more in number resulting in higher Young’s modulus and crushing stress compared to slower cooling rates of 0.09°C/min with less numerically but larger pore sizes. Controlled nucleation creates a narrow pore size distribution resulting in a uniform Young’s modulus and similar crushing stress compared to cakes with wider pore size distributions (spontaneous nucleation). FD lysozyme and BSA products cakes are strongest when mannitol and sucrose are used in combination at ~1:1 ratio compared to other formulation compositions. In summary, the findings offer a systematic understanding of the relationship of mechanical behaviour of FD cakes, processing conditions and formulation composition. The mechanical test method developed can potentially provide a quantitative critical quality attribute related to internal FD cake structure hence its robustness for handling and transportation. It will provide information on suitability of biopharmaceutical formulations including excipients for manufacture of robust FD cakes.
A More Informative Map: Inverting Thermal Orbital Phase and Eclipse Lightcurves of Exoplanets
Creators: name: Rauscher, E.
name: Suri, V.
name: Cowan, N. B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Only one exoplanet has so far been mapped in both longitude and latitude, but the James Webb Space Telescope should provide mapping-quality data for dozens of exoplanets. The thermal phase mapping problem has previously been solved analytically, with orthogonal maps---spherical harmonics---yielding orthogonal lightcurves---sinusoids. The eclipse mapping problem, let alone combined phase+eclipse mapping, does not lend itself to such a neat solution. Previous efforts have either adopted spherical harmonics, or various ad hoc map parameterizations, none of which produce orthogonal lightcurves. We use principal component analysis to construct orthogonal "eigencurves," which we then use to fit published 8 micron observations of the hot Jupiter HD 189733b. This approach has a few advantages over previously used techniques: 1) the lightcurves can be pre-computed, accelerating the fitting process, 2) the eigencurves are orthogonal to each other, reducing parameter correlations, and 3) the eigencurves are model-independent and are ranked in order of sensitivity. One notable result of our analysis is that eclipse-only mapping of HD 189733b is far more sensitive to the central concentration of dayside flux than to the eastward offset of that hotspot. Mapping can, in principle, suffer from degeneracies between spatial patterns and orbital parameters. Previous mapping efforts using these data have either assumed a circular orbit and precise inclination, or have been pessimistic about the prospects of eclipse mapping in the face of uncertain orbital parameters. We show that for HD 189733b the combined photometry and radial velocity are sufficiently precise to retire this concern. Lastly, we present the first map of brightness temperature, and we quantify the amplitude and longitude offset of the dayside hotspot.
description: revised version, accepted for publication in The Astronomical Journal
Additional file 1 of Blended teaching of medical ethics during COVID-19: practice and reflection
Creators: name: Chen, Min
name: Ye, Lipin
name: Weng, Yucen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1.
A Coupled-Channels Study of $^{11}Be$ Coulomb Excitation
Creators: name: Bertulani, C. A.
name: Canto, L. F.
name: Hussein, M. S.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study the effects of channel coupling in the excitation of $^{11}Be$ projectiles incident on heavy targets. The contribution to the excitation from the Coulomb and the nuclear fields in peripheral collisions are considered. Our results are compared with recent data on the excitation of the $\halfm$ state in $^{11}Be$ projectiles. We show that the experimental results cannot be explained, unless very unusual parameters are used.
description: 8 pages, 2 Postscript figures available upon request, corrected misprints in eqs. 2 and 5
BOUSSOLE
Creators: name: GOLBOL Melek
Publisher: name: Sismer
Year: 2000

description: Il s'agit ici des campagnes mensuelles sur le site du mouillage, dans le double but :
1) de vérifier le bon fonctionnement de la bouée et le bon état du mouillage ainsi que telecharger les données acquises,
2) de réaliser un ensemble de mesures complémentaires, nécessaires ou bien pour l'interprétation des mesures en continu réalisées par le mouillage, ou alors pour acquérir des paramètres complémentaires nécessaires aux études d'optique marine.Ces mesures additionnelles comprennent : profils CTD, pigments HPLC, absorption du phytoplancton, des particules, et matière dissous, poids sec, profils d'éclairement descendant et remontant, profils des propriétés optiques inhérentes, mesures atmosphériques (epaisseur optique des aérosols), mesures de la réflectance au-dessus de la surface, quadrillage de la zone au fluorimètre en continue.Le site BOUSSOLE (43°22'N, 7°54'E) est voisin du site DYFAMED. Il se situe dans la zone déclarée aux affaires Maritimes comme zone de travaux scientifiques et mouillage d'instruments scientifiques (sur les cartes marines).
My PhD thesis
Creators: name: Baker, Kate
Publisher: name: figshare
Year: 2018
Subjects: subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences
subject: 70707 Veterinary Microbiology (excl. Virology)

description: This is my PhD thesis 'The African straw-coloured fruit bat, Eidolon helvum, as a reservoir host for viral zoonoses' submitted for examination in September 2012 from the University of Cambridge (Newnham College) and the Institute of Zoology. I was examined (and passed) by Professors Drs Christian Drosten and Laurence Tiley in November 2012. The links below are the four main papers from the thesis by chapter.
Gamow-Teller strength in 54Fe and 56Fe
Creators: name: Caurier, E.
name: Poves, A.
name: Zuker, A. P.
name: Martinez-Pinedo, G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Through a sequence of large scale shell model calculations, total Gamow-Teller strengths ($S_+$ and $S_-$) in $^{54}$Fe and $^{56}$Fe are obtained. They reproduce the experimental values once the $στ$ operator is quenched by the standard factor of $0.77$. Comparisons are made with recent Shell Model Monte Carlo calculations. Results are shown to depend critically on the interaction. From an analysis of the GT+ and GT$-$ strength functions it is concluded that experimental evidence is consistent with the $3(N-Z)$ sum rule.
description: 6 pages, RevTeX 3.0 using psfig, 7 Postscript figures included using uufiles
Rare slips in fluctuating synchronized oscillator networks
Creators: name: Hindes, Jason
name: Schwartz, Ira B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: We study rare phase slips due to noise in synchronized Kuramoto oscillator networks. In the small-noise limit, we demonstrate that slips occur via large fluctuations to saddle phase-locked states. For tree topologies, slips appear between subgraphs that become disconnected at a saddle-node bifurcation, where phase-locked states lose stability generically. This pattern is demonstrated for sparse networks with several examples. Scaling laws are derived and compared for different tree topologies. On the other hand, for dense networks slips occur between oscillators on the edges of the frequency distribution. If the distribution is discrete, the probability-exponent for large fluctuations to occur scales linearly with the system size. However, if the distribution is continuous, the probability is a constant in the large network limit, as individual oscillators fluctuate to saddles while all others remain fixed. In the latter case, the network's coherence is approximately preserved.
Transgenic and optogenetic manipulation of inhibition in mouse visual thalamus
Creators: name: Ye, Zhiwen
Publisher: name: Imperial College London
Year: 2014

description: This thesis examines GABAA receptor (GABAAR) and GABAB receptor (GABABR) mediated inhibition within the mouse dorsal lateral geniculate nucleus (dLGN) with a particular emphasis on the significance of GABA release from local interneurons. The removal of the gamma2 subunit from thalamic relay neurons of the dLGN in the HDC-gamma2 mouse strain was shown to reduce the overall sIPSC frequency across all relay neurons with an absence of IPSCs in a subset of Y-type thalamic relay neurons. The IPSCs associated with the remaining relay neurons exhibited slower rise-times and decays and were insensitive to diazepam, indicating the absence of the gamma2 subunit. Potentiation of these slower IPSCs by DMCM further suggested that the remaining IPSCs were mediated by gamma1 subunit-containing GABAA receptors. In contrast, removal of the GABAB1 subunit resulted in a complete loss of postsynaptic GABABR responses within the mouse dLGN in all cells so far examined. The baclofen-induced membrane hyperpolarization was lost from HDC-GABAB1 cells and elevated ambient GABA concentrations resulted in a significantly smaller membrane hyperpolarization. Although HDC-GABAB1 mice did not exhibit a major visual deficit in a novel object recognition task, local field potential recordings during the animals sleep period revealed a shift in the power spectrum towards 1-4 Hz delta band of oscillatory activity locally within the visual cortex. I also identified the Sox14 gene as a marker for dLGN interneurons. Channelrhodopsin-2 (ChR2) activation of Sox14 interneurons not only gave rise to time-locked phasic inhibition in the dLGN relay neurons, this stimulation also induced tonic inhibition in an activity-dependent manner, mediated by the activation of extrasynaptic delta-containing GABAARs. However, action potential induced GABA release from interneuron is not a conspicuous feature of simultaneous paired interneuron to relay neuron recordings.
title: EJP SOIL Call Text of the 1st Internal Call (2020)
title: WP3 Internal Calls D3.2
titleType: AlternativeTitle
Creators: name: Adamczyk, Bartosz
name: Stangl, Rosemarie; Minixhofer, Pia
name: Rodríguez, Elena
Publisher: name: Zenodo
Year: 2024
Subjects: EU
funding
soil management
call
topic

description: The document describes the background and the topics of the 1st EJP SOIL internal call for research projects, and the process of applying funding for programme’s internal projects. It also includes the templates for application and planning budget and the list of the eligible institutions i.e. the partners of the EJP SOIL.
Ultraviolet Imaging of the z=0.23 Cluster Abell 2246
Creators: name: Cornett, Robert H.
name: Dorman, Ben
name: Smith, Eric P.
name: Fanelli, Michael A.
name: Oegerle, William R.
name: Bohlin, Ralph C.
name: Neff, Susan G.
name: O'Connell, Robert W.
name: Roberts, Morton S.
name: Smith, Andrew M.
name: Stecher, Theodore P.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present deep ultraviolet observations of a field containing the cluster Abell 2246 (z=0.225) which provide far-ultraviolet (FUV) images of some of the faintest galaxies yet observed in that bandpass. Abell 2246 lies within the field of view of Ultraviolet Imaging Telescope (UIT) observations of the quasar HS1700+64, which accumulated over 7100 seconds of UIT FUV exposure time during the Astro-2 mission in March 1995. For objects found on both the FUV and ground-based V-band images, we obtain FUV (l ~ 1520 A) photometry and V-band photometry, as well as mid-UV (l ~ 2490 A) photometry from UIT Astro-1 observations and ground-based I-band photometry. We find five objects in the images which are probably galaxies at the distance of Abell 2246, with FUV magnitudes (m(FUV)) between 18.6 and 19.6, and V magnitudes between 18.4 and 19.6. We find that their absolute FUV fluxes and colors imply strongly that they are luminous galaxies with significant current star formation, as well as some relatively recent, but not current, (> 400 Myr ago) star formation. We interpret the colors of these five objects by comparing them with local objects, redshift-corrected template spectra and stellar population models, finding that they are plausibly matched by 10-Gyr-old population models with decaying star formation, with decay time constants in the range 3 Gyr < t < 5 Gyr, with an additional color component from a single burst of moderate ( ~ 400-500 Myr) age. From derived FUV luminosities we compute current star formation rates. We compare the UV properties of Abell 2246 with those of the Coma cluster, finding that Abell 2246 has significantly more recent star formation, consistent with the Butcher-Oemler phenomenon.
description: Accepted for publication in the Astronomical Journal, June 1998. 17 Pages AAS latex, includes 4 bitmap .jpg format images and 4 other figures. PDF, Embedded Gzipped PS version (1.9Mb) TeX source and figures available at http://www.astro.virginia.edu/~bd4r/galaxies.html
Madrepora oculata Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Oculinidae
Madrepora
Madrepora oculata

description: Madrepora oculata [spec. nov.]
M. ramosa glabra concava, ramis alternis, superficie striis obliquis, stellis distiche alternis.
Hort. cliff. 481. Madrepora simplex ramosa, ramis teretibus laevibus solidiusculis, lamellis integris.
Worm. mus. 234.
Raj. hist. 62. Corallium album.
Tournef. inst. 573. Madrepora vulgaris.
Bauh. hist. 3. p. 793. Corallium album oculatum officinarum.
Imperat. nat. 627. Corallium album fistulosum.
Ellis corall. 95. t. 35. f. B. Corallium album majus.
Moris. hist. 3. p. 655. s. 15. t. 10. f. 1. Porus magnus Corallio affinis.
Gvalt. test. t. 24. Acropora alba, foraminibus stellatis amplioribus.
Habitat in Mari Siculo, Tyrrheno.
Caulis laevis, varie ramosus, solidus, versus basin cylin- drico-cavus. Superficies striis obsoletis, obliquis, parallelis. Stellae non prominent, sed pori alternati stellati.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 798, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Atmospheric and disk properties of young low mass stars and brown dwarfs: an infrared study
Creators: name: Tottle, Jonathan
Publisher: name: Imperial College London
Year: 2015

description: We test state-of-the-art model atmospheres for young low-mass stars and brown dwarfs in the infrared, by comparing the predicted synthetic photometry over 1.2-24um to the observed photometry of M-type spectral templates in star-forming regions. In both early and late young M types, the model atmospheres imply effective temperatures (Teff) several hundred Kelvin lower than predicted by the standard Pre-Main Sequence spectral type-Teff conversion scale (where the latter is based on theoretical evolutionary models). We postulate that in the early M types this discrepancy arises from remaining uncertainties in the treatment of atmospheric convection, whereas in the late M types it is likely due to an underestimation of dust opacity in the atmospheric models and an attendant overestimation of H2O opacity, due to insufficient backwarming by dust. Using the synthetic spectra to estimate stellar properties leads to reasonably accurate bolometric luminosities (Lbol), but overestimates radii (due to underestimated Teff) for the early and late young M types compared to evolutionary theory; this then leads to underestimations of age and mass, which we demonstrate for a large sample of young Cha I and Taurus sources. By selecting the model atmospheres which best represent the true stellar continuum at each spectral type, we then go on to infer the disk parameters for a selection of young, low-mass disk-bearing objects in Cha I by modelling the IR SEDs (again over 1.2-24um) using the radiative transfer code ttsre, coupled to the machine learning code skynet and a Bayesian parameter estimation. Just over half of the sample are able to be accurately fit by the analysis. No noticeable level of correlation is found between the extent of settling and grain growth in the disk and the stellar mass, an interesting result given the lessened gravitational/luminosity effects that lower mass objects should have on their disks. No correlation was also found between the disk thickness and accretion rate (a tracer of the system age), which, when coupled to the fact that a wide range of disk flaring indices are found, suggests that grain growth/settling occurs over a rapid timescale in the disk's early evolutionary sequence.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0289r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0289r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0289r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Arrhythmogenic sarcoplasmic reticulum calcium leak in isolated ventricular cardiomyocytes - changes in heart failure and mechanisms of pharmacological modulation
Creators: name: Sikkel, Markus
Publisher: name: Imperial College London
Year: 2014

description: Cardiomyocyte contraction involves sarcolemmal depolarization causing a small influx of Ca2+ which is then amplified via a larger release from the sarcoplasmic reticulum (SR). Under certain conditions SR Ca2+ is released in the absence of depolarization - so called SR Ca2+ leak. This is thought to be a key cause of arrhythmogenesis in heart failure (HF). The aims of this thesis were to assess how SR leak changes in a rat model of HF induced by chronic myocardial infarction (MI) and the mechanism of modulation using INa blockers. Several novel methodologies were developed to do this including the use of hierarchical statistical analysis which reduced the chance of type I errors in comparison to standard techniques. Detailed assessment of the HF model showed that there was fluid retention and eccentric hypertrophic remodelling of an impaired left ventricle by 16 weeks post MI which were more marked compared with earlier timepoints. Although under basal conditions Ca2+ leak was similar in HF and control cells, leak enhancement in response to isoprenaline was more marked in HF cells and there were significant heterogeneities in leak when comparing the borderzone to remote regions. At an earlier stage (8 weeks post MI) we found more frequent Ca2+ waves even under basal conditions. Analysis of Ca2+ leak in 3-D for the first time using a novel microscopy technique showed that arrhythmogenic waves originate from regions of preserved t-tubules. Finally we explored the use of flecainide to inhibit SR leak and showed that it acts via reduction of INa, which enhances Ca2+ efflux via the Na+/Ca2+ exchanger. In conclusion this thesis has drawn on several novel methodologies to gain a deeper understanding of SR leak, both in terms of how it changes in HF and by exploring a novel mechanism by which it can be reduced.
Reminiscences of George S. Van Schaick, 1950
Publisher: name: Columbia University
Year: 2021
Subjects: Government executives--New York (State)
Lawyers
Insurance--State supervision

description: New York State politics; State Insurance Department, 1931-1935; personal recollections of Alfred E. Smith, Fiorello H. La Guardia, Herbert Lehman, and Franklin D. Roosevelt
Strategies for the synthesis of oxetanes as desirable fragments for drug discovery
Creators: name: Morgan, Kate Frances
Publisher: name: Imperial College London
Year: 2015

description: Oxetanes are currently receiving attention as important motifs for drug discovery due to their desirable physicochemical properties. Novel small oxetane containing compounds were designed to access new areas of chemical space and to be suitable motifs for incorporation into drug-like compounds or as fragments appropriate for screening in fragment based drug discovery. Methodology to access oxetanes bearing functional groups was investigated, in particular a novel intramolecular C–C bond forming cyclisation was developed due to the sparcity of synthetic methods for oxetane preparation. 2-Aryl sulfonyl oxetanes, designed with desirable fragment-like properties, were synthesised in excellent yields and could be further derivatised in a variety of directions into more lead-like compounds via organometallic intermediates at the intact oxetane and aromatic rings. The oxetane fragments and lead-like derivatives were found to have good half-life values under acidic and basic conditions. In addition, computational analysis determined that there were three possible binding orientations of the fragments. [Molecular diagram appears here. To view, please open pdf attachment] 2-Sulfinyl oxetanes were also synthesised as interesting motifs. The sulfoxide-magnesium exchange was explored as a method to access an oxetanyl organometallic species and incorporate the oxetane motif into a wide variety of compounds. This was challenging, however interesting reactivity was observed. [Molecular diagram appears here. To view, please open pdf attachment] To increase the diversity of oxetane derivatives that could be accessed and the methodology available to incorporate the motif into larger compounds, the synthesis of 2,3-disubstituted oxetanes was explored using an intramolecular epoxide ring opening strategy. More substitution would allow further ways in which to functionalise the oxetane motifs. In addition initial investigation into methodology to incorporate the oxetane motif into a wide array of larger lead-like and drug-like molecules was performed. The 2-oxetanyl sulfinate salt, a potential radical precursor, was not successfully formed. However the 3-oxetanyl radical was obtained by decarboxylation, and successfully reacted with a variety of heterocycles.
Additional file 2 of Blended teaching of medical ethics during COVID-19: practice and reflection
Creators: name: Chen, Min
name: Ye, Lipin
name: Weng, Yucen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 2.
Heterophyton dengqenensis F. G. Wang 2014, comb. nov.
Creators: name: Wang, Fa-Guo
name: Xing, Fu-Wu
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Pteridopsida
Heterophyton
Heterophyton dengqenensis

description: 1. Heterophyton dengqenensis (X.W. Wu) F.G. Wang, comb. nov.
Basionym: Allophyton dengqenensis X.W. Wu (1982: 53, pl. VI, fig. 1; pl. VII, figs. 1-2).
Type:— CHINA. Xizang, Dingqing County: Badasongduo, Mesozoic Coal Series, PB 7263 (holotype, NIGPAS, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences).
Distribution: China, Xizang, Dingqing County, Badasongduo.
description: Published as part of Wang, Fa-Guo & Xing, Fu-Wu, 2014, Heterophyton, a new substitute name for Allophyton X. W. Wu (Pteridopsida), pp. 299-300 in Phytotaxa 163 (5) on page 299, DOI: 10.11646/phytotaxa.163.5.6, http://zenodo.org/record/5132505
Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37
Creators: name: Somchai Noppawan
name: Wiyada Mongkolthanaruk
name: Nuttika Suwannasai
name: Thanaset Senawong
name: Pairot Moontragoon
name: Jaursup Boonmak
name: Sujittra Youngme
name: Sirirath McCloskey
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: A new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC50 = 19.60 µg/mL), HT29 (IC50 = 17.31 µg/mL), HCT116 (IC50 = 14.28 µg/mL), MCF-7 (IC50 = 15.38 µg/mL), and Vero (IC50 = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines.
Spherical Shell Model description of rotational motion
Creators: name: Zuker, A. P.
name: Retamosa, J.
name: Poves, A.
name: Caurier, E.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Exact diagonalizations with a realistic interaction show that configurations with four neutrons in a major shell and four protons in another -or the same- major shell, behave systematically as backbending rotors. The dominance of the $q\cdot q$ component of the interaction is explained by an approximate form of SU3 symmetry. It is suggested that these configurations are associated with the onset of rotational motion in medium and heavy nuclei.
description: 7 pages, RevTeX 3.0 using psfig, 6 Postscript figures included using uufiles
Reduction of order and Fadeev-Jackiw formalism in generalized electrodynamics
Creators: name: Nogueira, A. A.
name: Palechor, C.
name: Ferrari, A. F.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The aim of this work is to discuss some aspects of the reduction of order formalism in the context of the Fadeev-Jackiw symplectic formalism, both at the classical and the quantum level. We start by reviewing the symplectic analysis in a regular theory (a higher derivative massless scalar theory), both using the Ostrogradsky prescription and also by reducing the order of the Lagrangian with an auxiliary field, showing the equivalence of these two approaches. The interpretation of the degrees of freedom is discussed in some detail. Finally, we perform the similar analysis in a singular higher derivative gauge theory (the Podolsky electrodynamics), in the reduced order formalism: we claim that this approach have the advantage of clearly separating the symplectic structure of the model into a Maxwell and a Proca (ghost) sector, thus complementing the understanding of the degrees of freedom of the theory and simplifying calculations involving matrices.
Evidence for Proportionate Partition Between the Magnetic Field and Hot Gas in Turbulent Cassiopeia A
Creators: name: Keohane, J. W.
name: Gotthelf, E. V.
name: Petre, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a deep X-ray observation of the young Galactic supernova remnant Cas A, acquired with the ROSAT High Resolution Imager. This high dynamic range (232 ks) image reveals low-surface-brightness X-ray structure, which appears qualitatively similar to corresponding radio features. We consider the correlation between the X-ray and radio morphologies and its physical implications. After correcting for the inhomogeneous absorption across the remnant, we performed a point by point (4" resolution) surface brightness comparison between the X-ray and radio images. We find a strong (r = 0.75) log-log correlation, implying an overall relationship of $\log(Σ_{_{\rm X-ray}}) \propto (2.21\pm0.05) \times \log(Σ_{_{\rm radio}})$. This is consistent with proportionate partition (and possibly equipartition) between the local magnetic field and the hot gas --- implying that Cas A's plasma is fully turbulent and continuously amplifying the magnetic field.
description: 8 pages with embedded bitmapped figures, Accepted by ApJ Letters 5/1/98
Development of a deep vein valve replacement
Creators: name: Moore, Hayley
Publisher: name: Imperial College London
Year: 2015

description: Background Chronic venous disease is a common, distressing and significant cause of health care expense. There have been few developments in the treatment of deep venous disease as the understanding of the clinical and pathophysiological significance of deep vein reflux and valve failure remains poor. Previous attempts to develop a prosthetic vein valve implant have been disappointing. Difficulties with early thrombosis led researchers to abandon their efforts many years ago. Attempts to create a valve implant should be revisited. Aims The aims of this project are to: evaluate variables around normal deep vein valves, to develop validated computational and laboratory flow models for deep venous function, and to develop and investigate a novel material to engineer a prototype bioprosthetic deep vein valve replacement. Methods Functional Anatomy: This is a prospective observational study evaluating subjects with normal deep veins. B and M Mode ultrasound, contrast (microbubble) enhanced ultrasound and dynamic magnetic resonance imaging of normal subjects was carried out. This has given the flow, velocity data and anatomical images required for the project. Modelling: A preliminary computational flow model has been developed using the data obtained from the imaging stage of the project. This is a 2-dimensional model incorprating flexible valve leaflets. A laboratory model of venous function, in the form of a flow rig has been created. Materials: Presently, polymers and polymer coated metal stents, used in the vascular system have several problems: they are very thrombogenic and they lack haemocompatibilty and biocompatibility, in addition they lack the required mechanical properties. A novel material that is biocompatible, a copolymer of methacrylolyoxyethyl phosphorylcholine (MPC), trimethylsilyl-2-propyl methacrylate (TMSPMA) and Hydroxypropyl methacrylate (HPMA), has been synthesised. Its properties have been modified by electrospinning and crosslinking to change its solubility and mechanical properties, without altering its biocompatibility. Impact This project aims to guide the development of a treatment for patients, for whom few options are available. Chronic venous disease and venous ulceration are painful and debilitating, potentially requiring years of treatment. Effective, minimally invasive treatment options could result in accelerated ulcer healing and improvements in symptoms and quality of life as well as reduced costs.
Additional file 3 of Blended teaching of medical ethics during COVID-19: practice and reflection
Creators: name: Chen, Min
name: Ye, Lipin
name: Weng, Yucen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 3.
Madrepora virginea Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Oculinidae
Madrepora
Madrepora virginea

description: Madrepora virginea [spec. nov.]
M. corallio subdichotomo solido albido, stellis sparsis prominulis.
Habitat in Pelago.
Corallium simile M. oculatae, a qua differt: Colore al- bido-purpurascente; Ramis rects, nec flexuosis; Caule solido, nec tubuloso; Stellis sparsis prominulis; nec distiche alternis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 798, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Reminiscences of George Samuel Schuyler, 1960
Publisher: name: Columbia University
Year: 2021
Subjects: African American soldiers
African American journalists
African American authors
African American newspapers
World War, 1939-1945--African Americans
African Americans--Civil rights
African Americans--Social conditions

description: Background, childhood, and education in Syracuse; job discrimination; enlistment United States Army, 1912; military transports, commission, segregation within armed forces; government civil service, 1919; Harlem; Marcus Garvey; THE MESSENGER; PITTSBURGH COURIER; magazine supplement, Chicago; differences among Negro leaders; southern travels; Socialist Party activities; National Association for the Advancement of Colored People; THE CRISIS; Negroes in politics; housing; interracial marriage; Liberia; consumer cooperatives; Ethiopia; American Negroes in World War II; race relations in Latin America; Negro journalism; Negroes and Jews; Negroes and Communist Party; National Negro Congress; March on Washington; impressions of Benjamin Davis, A. Philip Randolph, Chandler Owen, James W. Ivy, James Weldon Johnson, Roy Wilkins, H.L. Mencken, Walter White
The realistic collective nuclear Hamiltonian
Creators: name: Dufour, Marianne
name: Zuker, Andrés
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The residual part of the realistic forces ---obtained after extracting the monopole terms responsible for bulk properties--- is strongly dominated by pairing and quadrupole interactions, with important $στ\cdotστ$, octupole and hexadecapole contributions. Their forms differ from the schematic ones through normalizations that lead to a universal $A^{-1/3}$ scaling for all multipoles. Coupling strengths and effective charges are calculated and shown to agree with the observed values.
description: 20 pages, RevTeX 3.0 using psfig, 4 Postscript figures included using uufiles
The Formation of Disk-Bulge-Halo Systems and the Origin of the Hubble Sequence
Creators: name: Bosch, Frank C. van den
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the formation of disk-bulge-halo systems by including bulges in the Fall & Efstathiou theory of disk formation. This allows an investigation of bulge dominated disk galaxies, such as S0s and disky ellipticals. The aim of this paper is to examine whether spirals, S0s, and disky elllipticals all can be incorporated in one simple galaxy formation scenario. We investigate an inside-out formation scenario in which the inner, low angular momentum material is assumed to form the bulge. Stability arguments are used to suggest that this bulge formation is a self-regulating process in which the bulge grows until it is massive enough to allow the remaining gas to form a stable disk component. We search for the parameters and physical processes that determine the disk-to-bulge ratio, and therewith explain to a large extent the origin of the Hubble sequence. The spread in halo angular momenta coupled with a spread in the formation redshifts can explain the observed spread in disk properties and disk-to-bulge ratios from spirals to S0s. Disky ellipticals, however, are too compact to be incorporated. Upon introducing a galaxy formation efficiency that depends on redshift, as suggested by the small amount of scatter in the observed Tully-Fisher relation, this scenario naturally predicts a density-morphology relation, the amplitude of which depends on the baryon fraction of the Universe.
description: 34 pages, 6 figures (postscript). Submitted to ApJ
title: Frais d entretien d'un valet - Archives départementales de la Côte-d'Or, B 396
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: LaMOP
subject: Laboratoire de médiévistique occidentale de Paris

description: Quittance donnée par Guillaume de Salive, châtelain d’Avallon, à la Chambre des comptes de Bourgogne, du remboursement des sommes par lui engagées pour l’entretien à Avallon, durant 21 jours, d’Odon Le Chat, valet du duc de Bourgogne, et de son cheval
Document transcrit dans le cadre des ateliers de paléographie du Chancelier Rolin des Archives départements des Côtes d’Or
description: Source: https://archives.cotedor.fr/v2/site/AD21/web/media/04_apprendre/02_ateliers_chancelier_rolin/paleographie/confirmes/2014_2015/document_08.pdf
description: Source: https://www.nakala.fr/10.34847/nkl.8b2b7599
description: Frais d entretien d'un valet - Archives départementales de la Côte-d'Or, B 396
Gravitational clock compass in General Relativity
Creators: name: Puetzfeld, Dirk
name: Obukhov, Yuri N.
name: Lämmerzahl, Claus
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show how a suitably prepared set of clocks can be used to determine all components of the gravitational field in General Relativity. We call such an experimental setup a clock compass, in analogy to the usual gravitational compass. Particular attention is paid to the construction of the underlying reference frame. Conceptual differences between the clock compass and the standard gravitational compass, which is based on the measurement of the mutual accelerations between the constituents of a swarm of test bodies, are highlighted. Our results are of direct operational relevance for the setup of networks of clocks, for example in the context of relativistic geodesy.
description: 12 pages, 6 figures
Reminiscences of George Stroganoff-Scherbatoff, 1974
Publisher: name: Columbia University
Year: 2021
Subjects: Veterans

description: Childhood and education; Russian Naval General Staff, radio communications, 1916-17; 1917 Revolution, pre-revolutionary Russian society; family history; attempts to recover inheritance; United States naval officer, World War II; translator at Yalta, Potsdam, Paris Peace and Big Four Conferences; Soviet-US veterans exchange program, 1958-67
A real-world analysis of healthcare costs and relative risk of hyperprolactinemia associated with antipsychotic treatments in the United States
Creators: name: Cloutier, Martin
name: Mallik Greene
name: Touya, Maëlys
name: Gagnon-Sanschagrin, Patrick
name: Guerin, Annie
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Aims: Antipsychotic medications are associated with an increased risk of hyperprolactinemia, but differ in their propensity to cause this complication. This study aimed to assess the economic burden of hyperprolactinemia, and to compare its risk among adult patients using atypical antipsychotics (AAs) with a mechanism of action associated with no/low vs high/moderate prolactin elevation. Methods: This retrospective cohort study was based on US Commercial and Medicaid claims databases. Healthcare costs were compared between matched hyperprolactinemia and hyperprolactinemia-free cohorts using a two-part model. Risk of hyperprolactinemia was compared between patients receiving AAs with a mechanism of action associated with no/low (no/low prolactin elevation cohort) vs high/moderate prolactin elevation (high/moderate prolactin cohort) using logistic regression. Results: In the commercially insured sample, compared to the hyperprolactinemia-free cohort (n = 499), the hyperprolactinemia cohort (n = 499) was associated with incremental total healthcare costs of $5,732 ($20,081 vs $14,349; p = .004), and incremental medical costs of $3,861 ($13,218 vs $9,357; p = .040), mainly driven by hyperprolactinemia-related costs. In the Medicaid-insured sample, compared to the hyperprolactinemia-free cohort, the hyperprolactinemia cohort was associated with incremental total healthcare costs of $10,773 ($30,763 vs $19,990; p = .004), and incremental medical costs of $9,246 ($20,859 vs $11,613; p = .004), mainly driven by hyperprolactinemia-related and mental health-related costs. The odds of hyperprolactinemia in the no/low prolactin elevation cohort were 4–5-times lower than that in the high/moderate prolactin elevation cohort (odds ratio =0.21; p Limitations: Hyperprolactinemia may be under-reported in claims data. Conclusions: Hyperprolactinemia is associated with substantial healthcare costs. AAs associated with no/low prolactin elevation reduce the risk of hyperprolactinemia by 4–5-times compared to AAs associated with moderate/high prolactin elevation. Treatment options with minimal impact on prolactin levels may contribute to reducing hyperprolactinemia burden in AA-treated patients.
Isis Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Isididae
Isis

description: Isis [gen. nov.]
Flores ...
Stirps radicatus, lapideus, nudus, rigidus, geniculatus.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 799, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Microscopic mass formulae
Creators: name: Duflo, J.
name: Zuker, A. P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: By assuming the existence of a pseudopotential smooth enough to do Hartree-Fock variations and good enough to describe nuclear structure, we construct mass formulae that rely on general scaling arguments and on a schematic reading of shell model calculations. Fits to 1751 known binding energies for N,Z$\geq 8$ lead to rms errors of 375 keV with 28 parameters. Tests of the extrapolation properties are passed successfully. The Bethe-Weizsäcker formula is shown to be the asymptotic limit of the present one(s). The surface energy of nuclear matter turns out to be probably smaller than currently accepted.
description: 7 Pages, RevTeX 3.0
Starquake-induced Magnetic Field and Torque Evolution in Neutron Stars
Creators: name: Link, Bennett
name: Franco, Lucia M.
name: Epstein, Richard I.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The persistent increases in spin-down rate offsets seen to accompany glitches in the Crab and other pulsars suggest increases in the spin-down torque. We interpret these offsets as due to starquakes occurring as the star spins down and the rigid crust becomes less oblate. We study the evolution of strain in the crust, the initiation of starquakes, and possible consequences for magnetic field and torque evolution. Crust cracking occurs as equatorial material shears under the compressive forces arising from the star's decreasing circumference, and matter moves to higher latitudes along a fault inclined to the equator. A starquake is most likely to originate near one of the two points on the rotational equator farthest from the magnetic poles. The material breaks along a fault approximately aligned with the magnetic poles. We suggest that the observed offsets come about when a starquake perturbs the star's mass distribution, producing a misalignment of the angular momentum and spin axes. Subsequently, damped precession to a new rotational state increases the angle alpha between the rotation and magnetic axes. The resulting increase in external torque appears as a permanent increase in the spin-down rate. Repeated starquakes would continue to increase alpha, making the pulsar more of an orthogonal rotator.
description: 16 pages, 6 postscript figures, uses AASTeX macros, submitted to ApJ Letters