cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genomic perspectives on banana evolution and pseudo-stem pigmentation
Creators: name: Liu, Xin
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460203
subject: Evolutionary computation

description: The Musa genus, belonging to the monocot family Musaceae, can be categorized into two sections: sect. Musa and sect. Callimusa. Insights into the diversification and origin of the Musa species are of great significance for developing new banana cultivars (Musa spp.) with desirable traits such as disease resistance, yield, and nutritional content. Here, we assembled a telomere-to-telomere (T2T) gap-free reference genome of Musa cheesmanii, a potential contributor to banana cultivars in future breeding program. The genome size was estimated to be 432.16 Mb, with 41.96% of repetitive sequences, making it one of the most compact genomes in the genus Musa. Phylogenetic analysis of M. cheesmanii and banana progenitor species based on 9,388 single-copy genes grouped the sect. Musa into two clades: clade A, containing Musa acuminata and Musa schizocarpa, and clade B, including M. cheesmanii and Musa balbisiana. An inversion on chromosome 5 occurred independently in clade A, while a large reciprocal translocation between chromosomes 1 and 3 was found only in M. balbisiana. There were more tandem duplicated (TD) genes than proximal duplicated (PD) genes in the sect. Musa species. Additionally, higher Ka/Ks ratios of TD genes were found in M. acuminata and M. balbisiana. The effective population size of clade B species first decreased gently after the Naynayxungla Glaciation (0.50-0.78 Myr ago), while clade A species experienced a dramatic decline around the Penultimate Glaciation (135-194 kyr ago). Four key genes involved in anthocyanin biosynthesis showed higher expression in the pseudo-stem of M. cheesmanii, potentially accounting for its distinctive black color. Furthermore, different classes of anthocyanin compounds, present in high abundance in the pseudo-stem of M. cheesmanii, were detected. These findings shed light on the evolution of the Musa genus and the molecular underpinnings of pseudo-stem coloration, which could serve as an important genomic resource for banana breeding.
SNAP Households Adjust Their Expenditures and How They Spend Their Time in Response to Changes in Program Benefits
Creators: name: Rabbitt, Matthew P.
name: Kim, Jiyoon
name: Rabbitt, Matthew P.
name: Kim, Jiyoon
Publisher: name: Unknown
Year: 2019
Subjects: subject: Consumer/Household Economics
subject: Financial Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: SNAP
subject: food
subject: nutrition assistance
subject: American Recovery and Reinvestment Act of 2009 (ARRA)
subject: Supplemental Nutrition Assistance Program (SNAP)

description: The American Recovery and Reinvestment Act of 2009 (ARRA) mandated higher monthly benefits for households participating in USDA’s Supplemental Nutrition Assistance Program (SNAP). Subsequent legislation ended these higher benefits in November 2013. Researchers found that SNAP households spent less time on food shopping and meal preparation and more time in income-generating work following the sunset of the higher ARRA-mandated benefits.
Pesticide Exposures and Body Mass Index (BMI) of Pesticide Applicators From the Agricultural Health Study
Creators: name: LaVerda, Nancy L.
name: Goldsmith, David F.
name: Alavanja, Michael C. R.
name: Hunting, Katherine L.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology

description: Endocrine-disrupting chemicals, including pesticides, may be associated with weight gain. This is the first longitudinal study to examine a potential association between weight gain and pesticides using data on 8,365 male pesticide applicators from the Agricultural Health Study (AHS) cohort established in 1993. The relationship between total cumulative days of exposure to pesticide functional/chemical classes and to the four most frequently used individual pesticides was studied in relation to body mass index (BMI) at the time of 5-yr follow-up (beginning in 1998) with the length of the exposure period dating back to age 20 yr. Multiple regression, Spearman correlation, ordinal logistic regression, and logistic regression models all utilized a Bonferroni-adjusted p value, were adjusted for relevant covariates, and were stratified by state of residence (Iowa/North Carolina) and presence/absence of weight-related health conditions. Adjusted multiple regression yielded statistically significant positive parameter estimates for the study sample and Iowa subgroups with consistent findings for triazine herbicides and atrazine: Change in BMI per 100 cumulative pesticide exposure days ranged from 0.07 to 0.11 for triazine herbicides and from 0.10 to 0.19 for atrazine. Ordinal logistic regression compared normal weight with overweight and with obese using the zero exposure category as referent. Statistically significant adjusted odds ratios identified for the study sample and both state subgroups for the highest level of atrazine exposure ranged from 1.4 to 1.7. Further investigation is warranted to evaluate the associations identified here.
Towards the identification of the allosteric Phe-binding site in phenylalanine hydroxylase
Creators: name: Carluccio, Carla
name: Fraternali, Franca
name: Salvatore, Francesco
name: Fornili, Arianna
name: Zagari, Adriana
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The enzyme phenylalanine hydroxylase (PAH) is defective in the inherited disorder phenylketonuria. PAH, a tetrameric enzyme, is highly regulated and displays positive cooperativity for its substrate, Phe. Whether Phe binds to an allosteric site is a matter of debate, despite several studies worldwide. To address this issue, we generated a dimeric model for Phe–PAH interactions, by performing molecular docking combined with molecular dynamics simulations on human and rat wild-type sequences and also on a human G46S mutant. Our results suggest that the allosteric Phe-binding site lies at the dimeric interface between the regulatory and the catalytic domains of two adjacent subunits. The structural and dynamical features of the site were characterized in depth and described. Interestingly, our findings provide evidence for lower allosteric Phe-binding ability of the G46S mutant than the human wild-type enzyme. This also explains the disease-causing nature of this mutant.
Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11–48K and U11/U12–65K genes
Creators: name: Verbeeren, Jens
name: Prosanta Singha
name: Nurmi, Visa
name: Niemelä, Elina H
name: Frilander, Mikko J
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Physics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We have described such an autoregulatory mechanism for two core protein components, U11–48K and U11/U12–65K, of the U12-dependent spliceosome. This regulatory system uses an atypical splicing enhancer element termed USSE (U11 snRNP-binding splicing enhancer), which contains two U12-type consensus 5′ splice sites (5′ss). Evolutionary analysis of the USSE element from a large number of animal and plant species indicate that USSE sequence must be located 25–50 nt downstream from the target 3′ splice site (3′ss). Together with functional evidence showing a loss of USSE activity when this distance is reduced and a requirement for RS-domain of U11–35K protein for 3′ss activation, our data suggests that U11 snRNP bound to USSE uses exon definition interactions for regulating alternative splicing. However, unlike standard exon definition where the 5′ss bound by U1 or U11 will be subsequently activated for splicing, the USSE element functions similarly as an exonic splicing enhancer and is involved only in upstream splice site activation but does not function as a splicing donor. Additionally, our evolutionary and functional data suggests that the function of the 5′ss duplication within the USSE elements is to allow binding of two U11/U12 di-snRNPs that stabilize each others' binding through putative mutual interactions.
On the role of a Lipid-Transfer Protein. Arabidopsis ltp3 mutant is compromised in germination and seedling growth.
Creators: name: Pagnussat, Luciana A
name: Oyarburo, Natalia
name: Cimmino, Carlos
name: Pinedo, Marcela L
name: Canal, Laura De La
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Plant Lipid-Transfer Proteins (LTPs) exhibit the ability to reversibly bind/transport lipids in vitro. LTPs have been involved in diverse physiological processes but conclusive evidence on their role has only been presented for a few members, none of them related to seed physiology. Arabidopsis seeds rely on storage oil breakdown to supply carbon skeletons and energy for seedling growth. Here, Arabidopsis ltp3 mutant was analyzed for its ability to germinate and for seedling establishment. Ltp3 showed delayed germination and reduced germination frequency. Seedling growth appeared reduced in the mutant but this growth restriction was rescued by the addition of an exogenous carbon supply, suggesting a defective oil mobilization. Lipid breakdown analysis during seedling growth revealed a differential profile in the mutant compared to the wild type. The involvement of LTP3 in germination and seedling growth and its relationship with the lipid transfer ability of this protein is discussed.
Online backlash identification and estimation of remaining useful life in the joints of high speed industrial robots
Creators: name: KUMARAN, YOHANATHAN P.SIVAGNANA
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 400707
subject: Manufacturing robotics

description: In industrial robots, a performance issue is backlash, which is the clearance between mating gears of its joints. Over time, backlash grows through wear and tear, causing inaccuracies in robot positioning. Current methods in backlash detection are performed in low-speed and laboratory settings, or require offline diagnostics. These methods are impractical in actual manufacturing environments, where industrial robots operate continuously at high speeds. Other methods require additional sensors unavailable in typical industrial robots. This thesis presents an online method to quantify backlash and predict the remaining useful life (RUL) in an industrial robot performing cyclic production tasks, using only standard available sensors.
Towards the identification of the allosteric Phe-binding site in phenylalanine hydroxylase
Creators: name: Carluccio, Carla
name: Fraternali, Franca
name: Salvatore, Francesco
name: Fornili, Arianna
name: Zagari, Adriana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The enzyme phenylalanine hydroxylase (PAH) is defective in the inherited disorder phenylketonuria. PAH, a tetrameric enzyme, is highly regulated and displays positive cooperativity for its substrate, Phe. Whether Phe binds to an allosteric site is a matter of debate, despite several studies worldwide. To address this issue, we generated a dimeric model for Phe–PAH interactions, by performing molecular docking combined with molecular dynamics simulations on human and rat wild-type sequences and also on a human G46S mutant. Our results suggest that the allosteric Phe-binding site lies at the dimeric interface between the regulatory and the catalytic domains of two adjacent subunits. The structural and dynamical features of the site were characterized in depth and described. Interestingly, our findings provide evidence for lower allosteric Phe-binding ability of the G46S mutant than the human wild-type enzyme. This also explains the disease-causing nature of this mutant.
A comparative study of virtual hand prosthesis control using an inductive tongue control system
Creators: name: Johansen, Daniel
name: Sebelius, Fredrik
name: Jensen, Stig
name: Bentsen, Bo
name: Popović, Dejan B.
name: Struijk, Lotte N. S. Andreasen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: This study compares the time required to activate a grasp or function of a hand prosthesis when using an electromyogram (EMG) based control scheme and when using a control scheme combining EMG and control signals from an inductive tongue control system (ITCS). Using a cross-over study design, 10 able-bodied subjects used a computer model of a hand and completed simulated grasping exercises. The time required to activate grasps was recorded and analyzed for both control schemes. End session mean activation times (ATs; seconds) for the EMG control scheme grasps 1 -5 were 0.80, 1.51, 1.95, 2.93, and 3.42; for the ITCS control scheme grasps 1 ‒5 they were 1.19, 1.89, 1.75, 2.26, and 1.80. Mean AT for grasps 1 and 2 was statistically significant in favor of the EMG control scheme (p = 0.030; p = 0.004). For grasp 3 no statistical significance occurred, and for grasps 4 and 5 there was a statistical significance in favour of the ITCS control scheme (p = 0.048; p = 0.004). Based on the amount of training and the achieved level of performance, it is concluded that the proposed ITCS control scheme can be used as a means of enhancing prosthesis control.
Gluon distributions and mass decompositions of the pion and kaon
Creators: name: Han, Chengdong
name: Kou, Wei
name: Wang, Rong
name: Chen, Xurong
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the gluon distribution functions of pion and kaon in small-$x$ and large-$x$ regions, and compare them with the results obtained from lattice QCD and continuum Schwinger function methods. Whether in the small-$x$ region or the large-$x$ region, our gluon distribution of pion is consistent with the results of lattice QCD and continuum Schwinger function method. In addition, the first four moments of gluon distributions of pion and kaon at different $Q^{2}$ scales are calculated. Furthermore, we present the mass decompositions of pion and kaon with the dynamical parton distribution functions calculated by the DGLAP equation with parton-parton recombination corrections. The mass structures of pion and kaon are totally different from that of the proton.
description: 7 figures
On the role of a Lipid-Transfer Protein. Arabidopsis ltp3 mutant is compromised in germination and seedling growth.
Creators: name: Pagnussat, Luciana A
name: Oyarburo, Natalia
name: Cimmino, Carlos
name: Pinedo, Marcela L
name: Canal, Laura De La
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Plant Lipid-Transfer Proteins (LTPs) exhibit the ability to reversibly bind/transport lipids in vitro. LTPs have been involved in diverse physiological processes but conclusive evidence on their role has only been presented for a few members, none of them related to seed physiology. Arabidopsis seeds rely on storage oil breakdown to supply carbon skeletons and energy for seedling growth. Here, Arabidopsis ltp3 mutant was analyzed for its ability to germinate and for seedling establishment. Ltp3 showed delayed germination and reduced germination frequency. Seedling growth appeared reduced in the mutant but this growth restriction was rescued by the addition of an exogenous carbon supply, suggesting a defective oil mobilization. Lipid breakdown analysis during seedling growth revealed a differential profile in the mutant compared to the wild type. The involvement of LTP3 in germination and seedling growth and its relationship with the lipid transfer ability of this protein is discussed.
Evolutionary conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11-48K and U11/U12-65K genes
Creators: name: Verbeeren, Jens
name: Prosanta Singha
name: Nurmi, Visa
name: Niemelä, Elina H
name: Frilander, Mikko J
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Physics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to a formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We have described such an autoregulatory mechanism for two core protein components, U11-48K and U11/U12-65K, of the U12-dependent spliceosome. This regulatory system uses an atypical splicing enhancer element termed USSE (U11 snRNP-binding splicing enhancer), which contains two U12-type consensus 5′ splice sites (5′ss). Evolutionary analysis of the USSE element from a large number of animal and plant species indicate that USSE sequence must be located 25–50 nt downstream from the target 3′ splice site (3′ss). Together with functional evidence showing a loss of USSE activity when this distance is reduced and a requirement for RS-domain of U11-35K protein for 3′ss activation, our data suggests that U11 snRNP bound to USSE uses exon definition interactions for regulating alternative splicing. However, unlike standard exon definition where the 5′ss bound by U1 or U11 will be subsequently activated for splicing, the USSE element functions similarly as an exonic splicing enhancer and is involved only in upstream splice site activation but not serve as a splicing donor. Additionally, our evolutionary and functional data suggests that the function of the 5′ss duplication within the USSE elements is to allow binding of two U11/U12 di-snRNPs that stabilize each others' binding through putative mutual interactions.
Fluorescence Microscopy Analysis of Particulate Matter from Biomass Burning: Polyaromatic Hydrocarbons as Main Contributors
Creators: name: Garra, Patxi
name: Maschowski, Christoph
name: Liaud, Céline
name: Dieterlen, Alain
name: Trouvé, Gwenaëlle
name: Calvé, Stéphane Le
name: Jaffrezo, Jean-Luc
name: Gontrand Leyssens
name: Schönnenbeck, Cornelius
name: Kohler, Sophie
name: Gieré, Reto
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: New efficient approaches to the characterization of fly ash and particulate matter (PM) have to be developed in order to better understand their impacts on environment and health. Polycyclic aromatic hydrocarbons (PAH) contained in PM from biomass burning have been identified as genotoxic and cytotoxic, and some tools already exist to quantify their contribution to PM. Optical fluorescence microscopy is proposed as a rapid and relatively economical method to allow the quantification of PAH in different particles emitted from biomass combustion. In this study samples were collected in the flue gas of biomass-combustion facilities with nominal output ranging from 40 kW to 17.3 MW. The fly ash samples were collected with various flue gas treatment devices (multicyclone, baghouse filter, electrostatic precipitator); PM samples were fractionated from the flue gas with a DEKATI® DGI impactor. A method using fluorescence observations (at 470 nm), white-light observations and image processing has been developed with the aim of quantifying fluorescence per sample. Organic components of PM and fly ash, such as PAH, humic-like substances (HULIS) and water-soluble organic carbon (WSOC) were also quantified. Fluorescence microscopy analysis method assessment was first realized with fly ash that was artificially coated with PAH and HULIS. Total amounts of PAH in the three size fractions of actual PM from biomass burning strongly correlated with the intensities of fluorescence. These encouraging results contribute to the development of a faster and cheaper method of quantifying particle-bound PAH.Copyright 2015 American Association for Aerosol Research
On the role of a Lipid-Transfer Protein. Arabidopsis ltp3 mutant is compromised in germination and seedling growth
Creators: name: Pagnussat, Luciana A.
name: Oyarburo, Natalia
name: Cimmino, Carlos
name: Pinedo, Marcela L.
name: Canal, Laura De La
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Plant Lipid-Transfer Proteins (LTPs) exhibit the ability to reversibly bind/transport lipids in vitro. LTPs have been involved in diverse physiological processes but conclusive evidence on their role has only been presented for a few members, none of them related to seed physiology. Arabidopsis seeds rely on storage oil breakdown to supply carbon skeletons and energy for seedling growth. Here, Arabidopsis ltp3 mutant was analysed for its ability to germinate and for seedling establishment. Ltp3 showed delayed germination and reduced germination frequency. Seedling growth appeared reduced in the mutant but this growth restriction was rescued by the addition of an exogenous carbon supply, suggesting a defective oil mobilization. Lipid breakdown analysis during seedling growth revealed a differential profile in the mutant compared to the wild type. The involvement of LTP3 in germination and seedling growth and its relationship with the lipid transfer ability of this protein is discussed.
A Comparative Study of Virtual Hand Prosthesis Control Using an Inductive Tongue Control System
Creators: name: Sebelius, Fredrik
name: Johansen, Daniel
name: Jensen, Stig
name: Bentsen, Bo
name: Popović, Dejan B.
name: Struijk, Lotte N.S. Andreasen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Genetics
subject: Cell Biology
subject: Engineering
subject: Biochemistry

description: Purpose: This study compares the time required to activate a grasp or function of a hand prosthesis when using an electromyogram (EMG) based control scheme and when using a control scheme combining EMG and control signals from an Inductive Tongue Control System (ITCS).Method: Using a cross-over study design, 10 able-bodied subjects used both control schemes to control a computer model of a hand and completed simulated grasping exercise. The time required to activate grasps was recorded and analysed for both control schemes.Results: End session mean activation times (seconds) for the EMG control scheme grasp 1-5: 0.80, 1.51, 1.95, 2.93, 3.42, and for the ITCS control scheme grasp 1-5: 1.19, 1.89, 1.75, 2.26, 1.80. The difference in mean activation time between control schemes for grasp 1 and 2 was statistically significant in favour of the EMG control scheme (p = 0.030; p = 0.004). For grasp 3 no statistical significance occurred, and for grasp 4 and 5 there was a statistical significance in favour of the ITCS control scheme (p = 0.048; p = 0.004).Conclusions: Based on the amount of training and the achieved level of performance, it is concluded that the proposed ITCS control scheme can be used as a means of enhancing prosthesis control.
Fluorescence Microscopy Analysis of Particulate Matter from Biomass Burning: Polyaromatic Hydrocarbons as Main Contributors
Creators: name: Garra, Patxi
name: Maschowski, Christoph
name: Liaud, Céline
name: Dieterlen, Alain
name: Trouvé, Gwenaëlle
name: Calvé, Stéphane Le
name: Jaffrezo, Jean-Luc
name: Gontrand Leyssens
name: Schönnenbeck, Cornelius
name: Kohler, Sophie
name: Gieré, Reto
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: ABSTRACTNew efficient approaches to the characterization of fly ash and particulate matter (PM) have to be developed in order to better understand their impacts on environment and health. Polycyclic Aromatic Hydrocarbons (PAH) contained in PM from biomass burning have been identified as genotoxic and cytotoxic, and some tools already exist to quantify their contribution to PM. Optical fluorescence microscopy is proposed as a rapid and relatively economical method to allow the quantification of PAH in different particles emitted from biomass combustion. In this study samples were collected in the flue gas of biomass-combustion facilities with nominal output ranging from 40 kW to 17.3 MW. The fly ash samples were collected with various flue gas treatment devices (multicyclone, baghouse filter, electrostatic precipitator); PM samples were fractionated from the flue gas with a DEKATI® DGI impactor. A method using fluorescence observations (at 470 nm), white-light observations and image processing has been developed with the aim of quantifying fluorescence per sample. Organic components of PM and fly ash, such as PAH, Humic-Like Substances (HULIS) and water-soluble organic carbon (WSOC) were also quantified. Fluorescence microscopy analysis method assessment was firstly realized with fly ash that was artificially coated with PAH and HULIS. Total amounts of PAH in the three size fractions of actual PM from biomass burning strongly correlated with the intensities of fluorescence. These encouraging results contribute to the development of a faster and cheaper method of quantifying particle-bound PAH.
Synthesis of N-Acyl Triazolyl-Pyrazolines via. Acylation Initiated by the Hydrazone Moiety with Carboxylic Acids
Creators: name: Sivasubramaniyan, Archana
name: Murugan, Dinesh
name: Raja, Ranganathan
name: Sathishkumar Murugan
name: Shanmugavelan Poovan
name: Ponnuswamy Alagusundaram
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study, a mechanism envisaging the insitu generation of a new transient acylating intermediate has been proposed to explain the acylation.
Carbon-based electrodes for water electrolysis
Creators: name: LEE, JEN HOW DARYL
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 340305
subject: Physical properties of materials
classificationCode: 340601
subject: Catalysis and mechanisms of reactions
classificationCode: 400404
subject: Electrochemical energy storage and conversion
classificationCode: 340604
subject: Electrochemistry
classificationCode: 340301
subject: Inorganic materials (incl. nanomaterials)

description: Water electrolysis enables the production of clean hydrogen fuel using renewable electricity. However, the current reliance on expensive and scarce materials like platinum and iridium as electrode materials poses sustainability challenges. This thesis investigates the use of cheap and abundant Victorian brown coal to develop carbon-based electrodes for water electrolysis, offering a more sustainable path to green hydrogen fuel production.
Bismuth Phosphinates: Temperature-dependent Formation of a Macrocycle and a 1D Coordination Polymer
Creators: name: Metre, Ramesh K.
name: Kundu, Subrata
name: R Suriya Narayanan
name: Vadapalli Chandrasekhar
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: The reaction of Ph3Bi with a sterically hindered phosphinic acid, 1,1,2,3,3- pentamethyltrimethylene phosphinic acid, {cycP(O)OH·2H2O} at two different temperatures, one at refluxing conditions and another at room temperature in THF have been investigated. At refluxing conditions, cleavage of two Bi-C bonds (of BiPh3) leads to the formation of a 16-membered macrocycle [(PhBi)4(cycPO2)8] (1). On the other hand, the reaction at room temperature leads to only cleavage of one Bi-C bond affording a 1D polymer [(Ph2Bi)(cycPO2)]n, (1,1,2,3,3-pentamethyltrimethylene phosphinate is denoted as cycPO2) (2). Both the complexes were characterized by single crystal X-ray diffraction. In both of these complexes the phosphinate ligands are present in anisobidentate (bridging) coordination mode.
Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms
Creators: name: Fisher, Helen L
name: Murphy, Therese M
name: Arseneault, Louise
name: Caspi, Avshalom
name: Moffitt, Terrie E
name: Viana, Joana
name: Hannon, Eilis
name: Pidsley, Ruth
name: Burrage, Joe
name: Dempster, Emma L
name: Wong, Chloe C Y
name: Pariante, Carmine M
name: Mill, Jonathan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Childhood psychotic symptoms are associated with increased rates of schizophrenia, other psychiatric disorders, and suicide attempts in adulthood; thus, elucidating early risk indicators is crucial to target prevention efforts. There is considerable discordance for psychotic symptoms between monozygotic twins, indicating that child-specific non-genetic factors must be involved. Epigenetic processes may constitute one of these factors and have not yet been investigated in relation to childhood psychotic symptoms. Therefore, this study explored whether differences in DNA methylation at age 10 were associated with monozygotic twin discordance for psychotic symptoms at age 12. The Environmental Risk (E-Risk) Longitudinal Twin Study cohort of 2,232 children (1,116 twin pairs) was assessed for age-12 psychotic symptoms and 24 monozygotic twin pairs discordant for symptoms were identified for methylomic comparison. Children provided buccal samples at ages 5 and 10. DNA was bisulfite modified and DNA methylation was quantified using the Infinium HumanMethylation450 array. Differentially methylated positions (DMPs) associated with psychotic symptoms were subsequently tested in post-mortem prefrontal cortex tissue from adult schizophrenia patients and age-matched controls. Site-specific DNA methylation differences were observed at age 10 between monozygotic twins discordant for age-12 psychotic symptoms. Similar DMPs were not found at age 5. The top-ranked psychosis-associated DMP (cg23933044), located in the promoter of the C5ORF42 gene, was also hypomethylated in post-mortem prefrontal cortex brain tissue from schizophrenia patients compared to unaffected controls. These data tentatively suggest that epigenetic variation in peripheral tissue is associated with childhood psychotic symptoms and may indicate susceptibility to schizophrenia and other mental health problems.
The powerful lens galaxy cluster PLCK G287.0+32.9 ($θ_E \sim 43''$)
Creators: name: D'Addona, Maurizio
name: Mercurio, Amata
name: Rosati, Piero
name: Grillo, Claudio
name: Caminha, Gabriel
name: Acebron, Ana
name: Angora, Giuseppe
name: Bergamini, Pietro
name: Bozza, Valerio
name: Granata, Giovanni
name: Annunziatella, Marianna
name: Gargiulo, Adriana
name: Gobat, Raphael
name: Tozzi, Paolo
name: Girardi, Marisa
name: Lombardi, Marco
name: Meneghetti, Massimo
name: Schipani, Pietro
name: Tortorelli, Luca
name: Vanzella, Eros
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a new high-precision strong lensing model of PLCK G287.0$+$32.9, a massive lens galaxy cluster at $z=0.383$, with the aim to get an accurate estimation of its effective Einstein radius and total mass distribution. We also present a spectroscopic catalog containing accurate redshift measurements for 490 objects, including multiply-lensed sources and cluster member galaxies. We exploit high-quality spectroscopic data from three pointings of the VLT Multi Unit Spectroscopic Explorer, covering a central $3~\rm{arcmin}^2$ region of the cluster. We complete the spectroscopic catalog by including redshift measurements from VLT-VIMOS and KECK-DEIMOS. We identify 129 spectroscopic cluster member galaxies, with redshift values $0.360 \leq z \leq 0.405$ and $m_{\rm{F160W}} \leq 21$, and 24 photometric ones identified with a Convolutional Neural Network from ancillary HST imaging. We also identify 114 multiple images from 28 background sources, of which 84 images from 16 sources are new and the remaining ones were identified in previous work. The best-fitting lens model shows a root mean square separation value between the predicted and observed positions of the multiple images of $0.75''$, corresponding to an improvement in reconstructing the observed positions of the multiple images of a factor of $2.5$ with respect to previous models. Using the predictive power of our new lens model we find 3 new multiple images and we confirm the configuration of three systems of multiple images that were not used for the optimization of the model. The derived total mass distribution confirms this cluster to be a very prominent gravitational lens with an effective Einstein $θ_{E} = 43.4'' \pm 0.1''$, that is in agreement with previous estimates and corresponds to a total mass enclosed in the critical curve of $M_E = {3.33}_{-0.07}^{+0.02} \times{ 10^{14} M_\odot}$.
description: submitted to "Astronomy & Astrophysics" and accepted the on January 29th 2024
Two nematicidal furocoumarins from Ficus carica L. leaves and their physiological effects on pine wood nematode (Bursaphelenchus xylophilus)
Creators: name: Qunqun Guo
name: Guicai Du
name: Hongwei He
name: Hongkai Xu
name: Daosen Guo
name: Ronggui Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: The ethanol extract of the Ficus carica L. leaves was tested to show strong nematicidal activity against pine wood nematode (PWN), Bursaphelenchus xylophilus, causing 90.93% corrected mortality within 72 h at 1.0 mg/mL. From the ethyl acetate soluble fraction of the F. carica L. leaves extract, the main nematicidal constituents were obtained by bioassay-guided isolation and identified as linear furocoumarins bergapten (1) and psoralen (2) by mass and NMR spectral data analysis. Bergapten and psoralen had significant nematicidal activity against PWN with the LC50 values of 97.08 aKSnd 115.03 μg/mL within 72 h, respectively. The two furocoumarins could inhibit the activities of amylase, cellulase and acetylcholinesterase (AchE) from PWN. The morphologies of PWNs changed much after they were treated by bergapten and psoralen. The physiological effects of bergapten and psoralen on PWN might provide helpful clues to elucidate their nematicidal mechanisms.
Traumatic brain injury opens blood–brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect
Creators: name: Medcalf, Robert
name: Boyd, Ben J.
name: Galle, Adam
name: Daglas, Maria
name: Rosenfeld, Jeffrey V.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biotechnology
subject: Pharmacology
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: The opening of the tight junctions in the blood–brain barrier (BBB) following traumatic brain injury (TBI) is hypothesized to be sufficient to enable accumulation of large drug carriers, such as stealth liposomes, in a similar manner to the extravasation seen in tumor tissue via the enhanced permeability and retention (EPR) effect. The controlled cortical impact model of TBI was used to evaluate liposome accumulation in mice. Dual-radiolabeled PEGylated liposomes were administered either immediately after induction of TBI or at increasing times post-TBI to mimic the likely clinical scenario. The accumulation of radiolabel in the brain tissue ipsilateral and contralateral to the site of trauma, as well as in other organs, was evaluated. Selective influx of liposomes occurred at 0–8 h after injury, while the barrier closed between 8 and 24 hr after injury, consistent with reports on albumin infiltration. Significantly enhanced accumulation of liposomes occurred in mice subjected to TBI compared to anaesthetized controls, and accumulation was greater in the injured versus the contralateral side of the brain. Thus, stealth liposomes show potential to enhance drug delivery to the site of brain injury with a wide range of encapsulated therapeutic candidates.
Superconducting spin valves based on antiferromagnet/superconductor/antiferromagnet heterostructures
Creators: name: Bobkov, G. A.
name: Gordeeva, V. M.
name: Kamra, Lina Johnsen
name: Chourasia, Simran
name: Bobkov, A. M.
name: Kamra, Akashdeep
name: Bobkova, I. V.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Proximity effect at superconductor/antiferromagnet (S/AF) interfaces, which manifests itself as generation of Neel-type triplet correlations, leads to sensitivity of the superconducting critical temperature to the mutual orientation of the AF Neel vectors in AF/S/AF trilayers, which is called the spin-valve effect. Here we predict that the spin-valve effect in AF/S/AF heterostructures crucially depends on the value of the chemical potential of the superconducting interlayer due to the occurrence of the finite-momentum Neel triplet correlations. In addition we investigate equal-spin triplet correlations, which appear in AF/S/AF structures for non-aligned Neel vectors of the AFs, and their role in the nonmonotonic dependence of the superconducting critical temperature of the AF/S/AF structure on the mutual orientation of the AF Neel vectors. The influence of impurities on the spin-valve effect is also investigated.
Acarospora schorica is a Trimmatothelopsis
Creators: name: Knudsen, Kerry
name: G. P. Urbanavichus
name: Kocourková, Jana
name: Hodková, Eva
name: A. Tsurykau
Publisher: name: Zenodo
Year: 2022

description: This repository includes the alignment file used to reconstruct the phylogenetic tree (in .fas format) as well as the partition file.
ColdSpark project Deliverable D5.1: Basic Aspen/HYSYS models for lab and large-scale  prototypes based on results from WP1 and WP2, WP4
Creators: name: NORCE
Publisher: name: Zenodo
Year: 2024

description: Aspen/HYSYS models for lab and large-scale prototype are established for the ColdSpark® pilot testing and to support techno-economic / LCA analysis. The models are based on results from WP1, WP2 and WP4
Adherence to standard-dose or low-dose statin treatment and low-density lipoprotein cholesterol response in type 2 diabetes patients
Creators: name: F.M. De Vries
name: J. Voorham
name: E. Hak
name: P. Denig
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biotechnology
subject: Pharmacology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Objective:To determine the association between adherence, dose and low-density lipoprotein (LDL) cholesterol response in patients with type 2 diabetes initiating statin treatment.Research design and methods:This cohort study was performed using data for 2007–2012 from the Groningen Initiative to Analyse Type 2 Diabetes Treatment (GIANTT) database. The association between adherence to a standard-dose statin and LDL cholesterol response was assessed using linear regression, adjusting for covariates. The effect of low-dose versus standard-dose was assessed in a propensity-score matched cohort. Adherence rates, defined as the proportion of days covered (PDC), were estimated between statin initiation and LDL outcome measurement.Main outcome measure:LDL cholesterol level at follow-up.Results:The effect of adherence on LDL cholesterol response, measured in 2160 patients, was dependent on the baseline LDL cholesterol level. For patients with a baseline LDL cholesterol of 3.7 mmol/l and an adherence rate of 80%, a 40% reduction in LDL cholesterol was predicted. In the matched sample of 1144 patients, the treatment dose showed a difference in impact on the outcome for adherence rates higher than 50%. It was estimated that a patient with a baseline LDL cholesterol of 3.7 mmol/l will need an adherence rate of at least 76% on low-dose and 63% on standard-dose treatment to reach the LDL cholesterol target of 2.5 mmol/l.Limitations:Adherence was measured as the PDC, which is known to overestimate actual adherence. Also, we were not able to adjust for lifestyle factors.Conclusions:We determined the concurrent effect of treatment adherence and dose on LDL cholesterol outcomes. Given the adherence levels seen in clinical practice, diabetes patients initiating statin treatment are at high risk of not reaching the recommended cholesterol target, especially when they start on a low-dose statin.
Adherence to standard-dose or low-dose statin treatment and low-density lipoprotein cholesterol response in type 2 diabetes patients
Creators: name: F.M. De Vries
name: J. Voorham
name: E. Hak
name: P. Denig
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: To determine the association between adherence, dose and low-density lipoprotein (LDL) cholesterol response in patients with type 2 diabetes initiating statin treatment. This cohort study was performed using data for 2007–2012 from the Groningen Initiative to Analyse Type 2 Diabetes Treatment (GIANTT) database. The association between adherence to a standard-dose statin and LDL cholesterol response was assessed using linear regression, adjusting for covariates. The effect of low-dose versus standard-dose was assessed in a propensity-score matched cohort. Adherence rates, defined as the proportion of days covered (PDC), were estimated between statin initiation and LDL outcome measurement. LDL cholesterol level at follow-up. The effect of adherence on LDL cholesterol response, measured in 2160 patients, was dependent on the baseline LDL cholesterol level. For patients with a baseline LDL cholesterol of 3.7 mmol/l and an adherence rate of 80%, a 40% reduction in LDL cholesterol was predicted. In the matched sample of 1144 patients, the treatment dose showed a difference in impact on the outcome for adherence rates higher than 50%. It was estimated that a patient with a baseline LDL cholesterol of 3.7 mmol/l will need an adherence rate of at least 76% on low-dose and 63% on standard-dose treatment to reach the LDL cholesterol target of 2.5 mmol/l. Adherence was measured as the PDC, which is known to overestimate actual adherence. Also, we were not able to adjust for lifestyle factors. We determined the concurrent effect of treatment adherence and dose on LDL cholesterol outcomes. Given the adherence levels seen in clinical practice, diabetes patients initiating statin treatment are at high risk of not reaching the recommended cholesterol target, especially when they start on a low-dose statin.
The complexation of anions by chloro- and cyanoacetanilides; IR, 1H-NMR and computation study
Creators: name: Müllerová, Jana
name: Zajícová, Veronika
name: Řezanka, Michal
name: Matějka, Pavel
name: Čajan, Michal
name: Stibor, Ivan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Complexation ability of simple chloro- and cyanoacetanilides has been determined using IR as well as 1H-NMR titration experiments. Only 1:1 anion–amide complex stoichiometry has been found. The structures of several free anilides and their complexes with bromide anion have been studied by DFT calculation.