cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment
Creators: name: Stenzinger, Albrecht
name: Pfarr, Nicole
name: Endris, Volker
name: Penzel, Roland
name: Jansen, Lina
name: Wolf, Thomas
name: Herpel, Esther
name: Warth, Arne
name: Klauschen, Frederick
name: Kloor, Matthias
name: Roth, Wilfried
name: Bläker, Hendrik
name: Chang-Claude, Jenny
name: Brenner, Hermann
name: Hoffmeister, Michael
name: Weichert, Wilko
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Recent molecular profiling studies reported a new class of ultramutated colorectal cancers (CRCs), which are caused by exonuclease domain mutations (EDMs) in DNA polymerase ϵ (POLE). Data on the clinical implications of these findings as to whether these mutations define a unique CRC entity with distinct clinical outcome are lacking. We performed Sanger sequencing of the POLE exonuclease domain in 431 well-characterized patients with microsatellite stable (MSS) CRCs of a population-based patient cohort. Mutation data were analyzed for associations with major epidemiological, clinical, genetic, and pathological parameters including overall survival (OS) and disease-specific survival (DSS). In 373 of 431 MSS CRC, all exons of the exonuclease domain were analyzable. Fifty-four mutations were identified in 46 of these samples (12.3%). Besides already reported EDMs, we detected many new mutations in exons 13 and 14 (corresponding to amino acids 410–491) as well as in exon 9 and exon 11 (corresponding to aa 268–303 and aa 341–369). However, we did not see any significant associations of EDMs with clinicopathological parameters, including sex, age, tumor location and tumor stage, CIMP, KRAS, and BRAF mutations. While with a median follow-up time of 5.0 years, survival analysis of the whole cohort revealed nonsignificantly different adjusted hazard ratios (HRs) of 1.35 (95% CI: 0.82–2.25) and 1.44 (0.81–2.58) for OS and DSS indicating slightly impaired survival of patients with EDMs, subgroup analysis for patients with stage III/IV disease receiving chemotherapy revealed a statistically significantly increased adjusted HR (1.87; 95%CI: 1.02–3.44). In conclusion, POLE EDMs do not appear to define an entirely new clinically distinct disease entity in CRC but may have prognostic or predictive implications in CRC subgroups, whose significance remains to be investigated in future studies.
title: Múltiples lesiones intracraneales hipointensas en secuencia eco de gradiente T2: buscando un diagnóstico diferencial
Creators: name: Cortes Vela, Jesus
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neuroradiology brain
subject: MR
subject: CT

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Presentar el diagnóstico diferencial en resonancia magnética cuando nos encontramos ante múltiples lesiones hipointensas en la secuencia eco de gradiente T2 en el sistema nervioso central. Discutirlo y aprender a orientar el diagnóstico en...
Comparison of 2D and 3D compressed sensing for high-resolution TDM-MIMO radars
Creators: name: Roos, Fabian
name: Hügler, Philipp
name: Knill, Christina
name: Tovar Torres, Lizette Lorraine
name: Appenrodt, Nils
name: Dickmann, Jürgen
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: direction-of-arrival estimation
subject: sparse arrays
subject: automotive radar
subject: DDC 620 / Engineering & allied operations
subject: MIMO systems
subject: Radar
subject: Antenna arrays
subject: Parameter estimation
subject: Signal processing
subject: Compressed sensing (Telecommunication)
subject: Automobiles; Electronic equipment
subject: MIMO
subject: Radar
subject: Parameteridentifikation
subject: Antennengruppen
subject: Signalverarbeitung
subject: Komprimierte Abtastung
subject: Bordradar

description: In order to enhance the resolution of radar sensors, the sampling of the different measurement domains range, Doppler, and direction-of-arrival can be improved. This, for example, leads to the application of a sparse array for an increased angular resolution and an enhanced multiple-input multiple-output switching scheme for an increased maximum Doppler velocity. In this paper, an investigation is performed in order to determine the dimension where undersampling is most effective. As the measurement dimensions are linked, two different reconstruction approaches of the subsampled data are presented and evaluated. Measurements validate the effective reconstruction of the subsampled data.
Message from the program chairs
Creators: name: Sanfilippo, Antonio P.
name: Kim, Jongsung
name: Chua, Caslon
Publisher: name: Swinburne
Year: 2024

description: The program chairs introduce the proceedings of the 3rd International Conference on Human-Centric Computing (HumanCom-10), held at Cebu, Philippines on 11-13 August 2010.
Supplementary document for Probing variations of fibrous structures during the development of breast ductal carcinoma tissues via quantitative Mueller matrix imaging - 4724661.pdf
Creators: name: Dong, Yang
name: Shaoxiong, Liu
name: Shen, Yuanxing
name: He, Honghui
name: Ma, Hui
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Expanded descriptions of methods
Arabidopsis ETHYLENE RESPONSE FACTOR 8 (ERF8) has dual functions in ABA signaling and immunity
Creators: name: Cao, Feng Y.
name: DeFalco, Thomas A.
name: Moeder, Wolfgang
name: Li, Bo
name: Gong, Yunchen
name: Liu, Xiao-Min
name: Taniguchi, Masatoshi
name: Lumba, Shelley
name: Toh, Shigeo
name: Shan, Libo
name: Ellis, Brian E.
name: Desveaux, Darrell
name: Yoshioka, Keiko
Publisher: name: BioMed Central
Year: 2018

description: Background: ETHYLENE RESPONSE FACTOR (ERF) 8 is a member of one of the largest transcription factor families in plants, the APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) superfamily. Members of this superfamily have been implicated in a wide variety of processes such as development and environmental stress responses. Results: In this study we demonstrated that ERF8 is involved in both ABA and immune signaling. ERF8 overexpression induced programmed cell death (PCD) in Arabidopsis and Nicotiana benthamiana. This PCD was salicylic acid (SA)-independent, suggesting that ERF8 acts downstream or independent of SA. ERF8-induced PCD was abolished by mutations within the ERF-associated amphiphilic repression (EAR) motif, indicating ERF8 induces cell death through its transcriptional repression activity. Two immunity-related mitogen-activated protein kinases, MITOGEN-ACTIVATED PROTEIN KINASE 4 (MPK4) and MPK11, were identified as ERF8-interacting proteins and directly phosphorylated ERF8 in vitro. Four putative MPK phosphorylation sites were identified in ERF8, one of which (Ser103) was determined to be the predominantly phosphorylated residue in vitro, while mutation of all four putative phosphorylation sites partially suppressed ERF8-induced cell death in N. benthamiana. Genome-wide transcriptomic analysis and pathogen growth assays confirmed a positive role of ERF8 in mediating immunity, as ERF8 knockdown or overexpression lines conferred compromised or enhanced resistance against the hemibiotrophic bacterial pathogen Pseudomonas syringae, respectively. Conclusions: Together these data reveal that the ABA-inducible transcriptional repressor ERF8 has dual roles in ABA signaling and pathogen defense, and further highlight the complex influence of ABA on plant-microbe interactions.
Backfill pressures within a reinstated trench: The Gatineau field project.
Creators: name: Crawford, J. James R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Civil.

description: To the backdrop of shrinking municipal budgets and aging water distribution system infrastructure, the National Research Council of Canada undertook a joint research project with the City of Gatineau, PQ, to better understand the nature of backfill pressures acting through the reinstated trench and upon buried water pipe. This thesis first presents the general details of this joint project focusing on backfill temperature and pressure data for the period August 1994 to August 1996. These data are then analyzed leading to a description of the relationship between frost depth and backfill pressure. Contrary to experience, the trend that emerges, in the case of the Gatineau field site, is that pressure and frost depth are inversely related. Finally, problems associated with the data and related to instrumentation are explored with the objective of developing guidelines or recommendations for the development of future field research sites.
Built-in self-test techniques for analog and mixed signal circuits
Creators: name: Zakizadeh, Jila
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, System Science.

description: The present thesis attempts to develop new techniques for testing analog parts of embedded cores-based mixed signal integrated circuits and systems. In particular, the oscillation based test methodologies have been investigated in the thesis. In the oscillation based test methods, the circuit under test (CUT) is first converted to an oscillator in the test mode and the oscillation parameters, viz. frequency, amplitude, etc. are then measured. Any deviation of these parameters causes either the oscillation frequency of the converted CUT to differ from its nominal value, or the converted CUT stops oscillation altogether. For evaluation purpose, a program has been written in C to help us in simulating our test methodologies. The program is used to inject faults to the circuit under test. The detailed experimental results provided give frequency and amplitude measurements data performed on the individual circuit blocks together with fault coverage. In this work, however, only catastrophic faults were considered. The simulation experiments carried out on different circuits not only demonstrate that the developed approaches are quite feasible but show in addition that the fault coverage is quite satisfactory (100%) in all cases.
title: Patología pancreática en niños: enfoque radiológico
Creators: name: Muro Velilla, Dolores
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Paediatric
subject: Abdomen
subject: Pancreas
subject: Ultrasound
subject: CT
subject: MR

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Exponer una visión general del desarrollo embrionario del páncreas para una mejor comprensión de las anomalías congénitas más frecuentes en la edad pediátrica. Ilustrar la patología pancreática y mostrar los hallazgos de imagen...
title: Risk of sensitization and allergy in Ragweed workers
title: a pilot study
titleType: Subtitle
Creators: name: Brandt, Oliver
name: Zuberbier, Torsten
name: Bergmann, Karl-Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Due to its high allergenic potential Ambrosia artemisiifolia has become a health threat in many European countries during the last few decades. Hence, several cities and communities initiated ragweed eradication campaigns. In Berlin, Germany, so-called Ambrosia scouts are being assigned the task of finding and eliminating this weed. We sought to evaluate the potential risk of sensitization and allergy in these individuals. Findings In order to assess the risk of sensitization and allergy, we followed-up 20 Ambrosia scouts by skin-prick test with inhalant allergens, immunoserological and pulmonary function tests. Additionally, medical conditions were evaluated by a questionnaire especially designed for this study. Despite close contact to ragweed over a median duration of 13.8 months, none of the participants became sensitized or allergic to ragweed. One individual developed a clinical non- relevant sensitization towards the taxiconomically-related plant mugwort. A decline in relative FEV1 was most probably due to heavy smoking. Conclusions Our surprising findings suggest that intensive contact and exposure to high ragweed pollen concentrations do not necessarily result in sensitization and/or allergy, meaning that the allergenic potential of this weed might be lower than hitherto expected. However, it is also conceivable that continuous exposure to high allergen levels induced tolerance in the ragweed workers. Due to the relatively small number of subjects studied, our results might be biased and therefore investigations on larger study groups are needed.
title: Cloaca pélvica por fístula intestinal secundaria a radioterapia.
Creators: name: Escudero Caro, maría trinidad
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Pelvis
subject: Small bowel
subject: Oncology

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
...
Ethanol Recovery from Carbon Dioxide Stripped Ethanol-Water Vapor Mixture Using Adsorption
Creators: name: Hashi, Mohamed
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Engineering, Chemical.

description: In this research project, adsorption is used in conjunction with carbon dioxide stripping to increase the efficiency of ethanol production by decreasing the effect of the product inhibition. The reduction in product inhibition is particularly important when ethanol is produced from the lignocellulosic biomass because genetically-modified microorganisms able to use all fermentable sugars are less tolerant to ethanol. Carbon dioxide removes some ethanol from the fermentation broth and reduces the level of ethanol toxicity, while adsorption is used to recover the entrained ethanol from the vapour phase. A series of adsorption screening experiments were performed to compare four activated carbon adsorbents and two hydrophobic ZSM-5 type zeolites. One activated carbon (WV-B 1500) exhibited the highest ethanol capacity. Adsorption isotherms for ethanol and water in the presence of carbon dioxide at different temperatures were determined. The temperature-dependent Toth isotherm model provided satisfactory fits for these isotherms. Ethanol adsorption experiments with and without the presence of water were conducted and showed similar ethanol adsorption capacities indicating that the presence of water has negligible effect for ethanol adsorption. A mathematical model was developed to predict the adsorption performance of activated carbon WV-B 1500 for ethanol vapour adsorption in the presence of carbon dioxide and water. The model takes into account changes in velocity due to adsorption, heat effects during adsorption, and heat losses to the surroundings. The model was validated with experimental data. Finally the model was used to predict the adsorption working capacities to assess the performance of the adsorption process in an industrial process. An economic analysis was performed by comparing a simulated base case ethanol production plant with a similar process coupled with carbon dioxide stripping and adsorption technology. The process was modeled using Aspen HYSYS to perform material and energy balances. The packed bed adsorption system, operating as a temperature-swing adsorption (TSA) or a vacuum-swing adsorption (VSA) system, was simulated to evaluate the performance of the adsorption system and to size and cost the associated equipment. Preliminary results showed that the grass roots cost for the ethanol production process coupled with carbon dioxide stripping and adsorption technology for three different TSA (purge gas at 80, 100, and 120°C) and VSA (adsorption pressure at 0.5, 0.2, and 0.1 atm) systems were more cost effective than the base case ethanol plant.
title: Desarrollando la planificación preoperatoria de la los colgajos DIEP con angiografía TC multicorte.
Creators: name: Casares Santiago, Miguel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Grafts
subject: Outcomes analysis
subject: CT-Angiography
subject: Breast
subject: Arteries / Aorta
subject: Abdomen

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
¿QUÉ ES EL COLGAJO DIEP? La reconstrucción mamaria tras mastectomía es una parte esencial del tratamiento global de la paciente con cáncer de mama. Puede realizarse con prótesis o con tejido autólogo (colgajos). El colgajo de perforantes de...
Future temporal reference in Brazilian Portuguese: Past and present
Creators: name: Malvar, Elisabete Da Silva
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Language, Linguistics.

description: Different forms convey future temporal reference in Portuguese. The recognition of these forms is a starting point towards examining their actual usage in the language. Of four acknowledged future forms, only two, i.e. the periphrastic ir + infinitive and the present variants, are productively used in contemporary spoken Brazilian Portuguese. There was therefore a need for reconstructing the future temporal reference system of early Portuguese, in order to shed light on the development of these forms in the future sector. This study employs the methods of comparative and variationist linguistics in diachronic and synchronic data to analyse this development. These methods made it possible to identify the conditioning factors contributing to the selection of the variants in future contexts throughout the centuries and establish the direction of the linguistic evolution. The first analyses concern the use of the future variants in the sixteenth and eighteenth centuries. They reveal that three variants were productively used to express the future: the synthetic future, haver + infinitive and the present. The synthetic future, which is acknowledged as the default form by prescriptive literature, had the highest overall probability of occurrence at that time, and was mainly favoured by contingent events, stative verbs and affirmative statements. The second analyses concern the use of the variants in the nineteenth century: the synthetic future, haver + infinitive, the present and ir + infinitive. In that century, the synthetic future lost two of its favoured contexts, contingent events and affirmative utterances, to the present variant and ir + infinitive, respectively. That century witnessed the emergence of an adverbial specification pattern in Brazilian Portuguese that has also been observed in French. The last analyses are related to the use of the future variants in the twentieth century. The results for the written data reveal that (i) haver + infinitive moved away from the future sector; (ii) the synthetic future declined; and (iii) the use of ir + infinitive highly increased. In the spoken data, only contingency and adverbial specification retained the present variant in the language. Ir + infinitive has almost completed its process of grammaticalization. This research reveals that the future variants have been in variation for centuries in Portuguese, and have been involved in a complex process of incursion and withdrawal from the future context, which ultimately changed the representation of future temporal reference in contemporary Brazilian Portuguese. The variationist methodology makes it possible to ascertain that the difference in frequency of variant usage in the different centuries is correlated to their displacement of or expansion into specific linguistic contexts.
Green Economy
Creators: name: Lutz, Christian
name: Zieschank, Roland
name: Drosdowski, Thomas
Publisher: name: My University
Year: 2015
Subjects: subject: Grüne Wirtschaft
subject: Umweltökonomische Gesamtrechnung
subject: Wirtschaftswandel
subject: Energiewende
subject: Green Economy
subject: Messkonzept
subject: Indikator
subject: Wirtschaftlicher Wandel
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Vor dem Hintergrund der Diskussion um eine Green Economy und nachhaltige Wohlfahrtsmessung wurde im Rahmen des Forschungsvorhabens ein Konzept zur Messung entworfen. Ausgehend von einer Synopse relevanter Messkonzepte werden Lücken in den bisherigen Konzepten aufgezeigt und Vorschläge für ein geeignetes Indikatorensystem entwickelt. Das Messkonzept umfasst sechs Dimensionen: (A) Umweltnutzung und Umweltschäden, (B) Naturkapital, (C) Umweltbezogene Lebensqualität, (D) Green Economy: Ökonomische Dimension und Handlungsfelder, (E) Politik: Rahmenbedingungen und Maßnahmen sowie (F) Hintergrundinformationen: ökonomischer und sozialer Rahmen. Entlang dieser Dimensionen werden Indikatoren vorgeschlagen, die zum Teil aus bereits verfügbaren Daten gebildet werden können und zum Teil den Charakter von wünschbaren Indikatoren haben. Im Rahmen eines Praxistests wird das Messkonzept mittels Szenarioanalyse am Beispiel der Energiewende in Deutschland geprüft. Es ergeben sich sowohl national als auch international Nutzungsmöglichkeiten des Indikatorenkonzepts im Bereich der Transformationsforschung wie im Bereich der Umweltpolitik.
In Vivo Monosynaptic Excitatory Transmission between Layer 2 Cortical Pyramidal Neurons
Creators: name: Jouhanneau, Jean-Sébastien
name: Kremkow, Jens
name: Dorrn, Anja L.
name: Poulet, James F.A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Little is known about the properties of monosynaptic connections between identified neurons in vivo. We made multiple (two to four) two-photon targeted whole-cell recordings from neighboring layer 2 mouse somatosensory barrel cortex pyramidal neurons in vivo to investigate excitatory monosynaptic transmission in the hyperpolarized downstate. We report that pyramidal neurons form a sparsely connected (6.7% connectivity) network with an overrepresentation of bidirectional connections. The majority of unitary excitatory postsynaptic potentials were small in amplitude (<0.5 mV), with a small minority >1 mV. The coefficient of variation (CV = 0.74) could largely be explained by the presence of synaptic failures (22%). Both the CV and failure rates were reduced with increasing amplitude. The mean paired-pulse ratio was 1.15 and positively correlated with the CV. Our approach will help bridge the gap between connectivity and function and allow investigations into the impact of brain state on monosynaptic transmission and integration.
nIFTy cosmology: The clustering consistency of galaxy formation models
Creators: name: Pujol, Arnau
name: Skibba, Ramin A.
name: Gaztañaga, Enrique
name: Benson, Andrew
name: Blaizot, Jeremy
name: Bower, Richard
name: Carretero, Jorge
name: Castander, Francisco J.
name: Cattaneo, Andrea
name: Cora, Sofia A.
name: Croton, Darren
name: Cui, Weiguang
name: Cunnama, Daniel
name: De Lucia, Gabriella
name: Devriendt, Julien E.
name: Elahi, Pascal J.
name: Font, Andreea
name: Fontanot, Fabio
name: Garcia-Bellido, Juan
name: Gargiulo, Ignacio D.
name: Gonzalez-Perez, Violeta
name: Helly, John
name: Henriques, Bruno M. B.
name: Hirschmann, Michaela
name: Knebe, Alexander
name: Lee, Jaehyun
name: Mamon, Gary A.
name: Monaco, Pierluigi
name: Onions, Julian
name: Padilla, Nelson D.
name: Pearce, Frazer R.
name: Power, Chris
name: Somerville, Rachel S.
name: Srisawat, Chaichalit
name: Thomas, Peter A.
name: Tollet, Edouard
name: Vega-Martínez, Cristian A.
name: Yi, Sukyoung K.
Publisher: name: Swinburne
Year: 2024

description: We present a clustering comparison of 12 galaxy formation models [including semi-analytic models (SAMs) and halo occupation distribution (HOD) models] all run on halo catalogues and merger trees extracted from a single Λ cold dark matter N-body simulation. We compare the results of the measurements of the mean halo occupation numbers, the radial distribution of galaxies in haloes and the two-point correlation functions (2PCF). We also study the implications of the different treatments of orphan (galaxies not assigned to any dark matter subhalo) and non-orphan galaxies in these measurements. Our main result is that the galaxy formation models generally agree in their clustering predictions but they disagree significantly between HOD and SAMs for the orphan satellites. Although there is a very good agreement between the models on the 2PCF of central galaxies, the scatter between the models when orphan satellites are included can be larger than a factor of 2 for scales smaller than 1 h-1 Mpc. We also show that galaxy formation models that do not include orphan satellite galaxies have a significantly lower 2PCF on small scales, consistent with previous studies. Finally, we show that the 2PCF of orphan satellites is remarkably different between SAMs and HOD models. Orphan satellites in SAMs present a higher clustering than in HOD models because they tend to occupy more massive haloes. We conclude that orphan satellites have an important role on galaxy clustering and they are the main cause of the differences in the clustering between HOD models and SAMs.
title: Shock hipovolémico. Hallazgos en TC
Creators: name: Arenaza Choperena, Gorka
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Haemodynamics / Flow dynamics
subject: CT
subject: Emergency

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Familiarizar al radiólogo con hallazgos cadavez más frecuentes en la práctica habitual,
gracias a la mejoría en el manejo del paciente crítico y a la disponibilidad de equiposde TC multidetectoren los servicios...
title: Circulación colateral de pared abdominal: Anatomía normal y patológica mediante Angio-TCMD-64.
Creators: name: Ovelar Ferrero, Ainhoa
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Computer Applications-3D
subject: CT-Angiography
subject: Vascular
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Recuerdo anatómico de la circulación arterial y venosa dela pared abdominal. Estudio delos procesos patológicos que provocan circulación colateral en la pared abdominal,
tanto arterial como venosa,ydescripción delos circuitos y anastomosis a...
Motor telephony: policy responses
Creators: name: Jessop, Glenn
Publisher: name: Swinburne
Year: 2024

description: In many respects, mobile phones have fitted into the folds of everyday life with minimal fuss. Building on the developments and experiences of telegraphy and landline telephony, people’s use of the device to communicate with others at a distance has mostly been a natural and taken-for-granted progression. Yet the emergence and widespread adoption of mobile telephony has also been accompanied by unforeseen consequences. The mobile phone’s use in vehicles and the effect this has on road safety is one example, and forms the focus of this paper. Tragic road deaths resulting from phone use, media coverage and an increasing amount of research attention have created concern and pushed the practice onto the public policy agenda. A number of questions have been posed. How does phone use affect driving performance? Is it a serious road safety issue? What is the best way to manage the risks? Should mobile phone use while driving be legally banned? And, if so, should both hand-held and hands-free be prohibited? Or is self-regulation a more appropriate strategy? As we explore the rationales, processes and deliberations of government in grappling with the regulation of motor telephony, we see the answers are not straightforward. This is a controversial and complex area of regulation, one which involves a diverse array of groups with different interests and motivations.
System performance of a 79 GHz high-resolution 4D imaging MIMO radar with 1728 virtual channels
Creators: name: Schwarz, Dominik
name: Riese, Nico
name: Dorsch, Ines
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Advanced driver assistance systems (ADAS)
subject: Automotive radar
subject: Chirp sequence modulation
subject: Direction-of-arrival (DoA) estimation
subject: Frequency modulated continuous wave (FMCW)
subject: Imaging radar
subject: Local oscillator (LO) feedthrough
subject: Mm-wave
subject: Multiple-input multiple-output (MIMO)
subject: Time delay correction
subject: DDC 620 / Engineering & allied operations
subject: Imaging systems
subject: Millimeter waves
subject: FMCW-Radar
subject: Millimeterwelle
subject: MIMO

description: Future driver assistance and autonomous driving systems require high-resolution 4D imaging radars that provide detailed and robust information about the vehicle’s surroundings, even in poor weather or lighting conditions. In this work, a novel high-resolution radar system with 1728 virtual channels is presented, exceeding the state-of-the-art channel count for automotive radar sensors by a factor of 9. To realize the system, a new mixed feedthrough and distribution network topology is employed for the distribution of the ramp oscillator signal. A multilayer printed circuit board is designed and fabricated with all components assembled on the back side, while the radio frequency signal distribution is on a buried layer and only the antennas are on the front side. The array is optimized to enable both multipleinput multiple-output operation and transmit beamforming. A sparse array with both transmit and receive antennas close to the transceivers is realized to form a 2D array with a large unambiguous region of 130◦ × 75◦ with a maximal sidelobe level of −15 dB. The array features a 3 dB beamwidth of 0.78◦ × 3.6◦ in azimuth and elevation, respectively. Radar measurements in an anechoic chamber show that even the individual peaks of the absorber in the chamber can be detected and separated in the range-angle cut of the 4D radar image. The performance is validated by measurements of a parking lot, where cars, a pedestrian, a fence, and a street lamp can be detected, separated, and estimated correctly in size and position.
'Who pays in the end?': the personal and political implications of financial abuse of women in intimate partner relationships
Creators: name: Branigan, Elizabeth
Publisher: name: Swinburne
Year: 2024

description: Women in intimate partner relationships may experience financial abuse in a variety of forms. In this article the author examines the pre-conditions under which financial abuse of women occurs and persists. She employs a number of first hand narratives to illustrate both the severity and the invisibility of such abuse. The costs of this abuse to women and children are explored and recommendations offered for policy solutions to redress the problem.
Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY)
Creators: name: Finger, Elizabeth
name: Berry, Scott
name: Cummings, Jeffrey
name: Coleman, Kristy
name: Hsiung, Robin
name: Feldman, Howard H.
name: Boxer, Adam
Publisher: name: BioMed Central
Year: 2018

description: Background: There are currently no treatments for empathy deficits in neuropsychiatric disorders. Acute administration of the hormone oxytocin has been associated with symptomatic improvements across animal models and several neuropsychiatric disorders, but results of the majority of oxytocin randomised controlled trials (RCTs) of longer duration have been negative or inconclusive. This lack of efficacy of may be due to rapid habituation to oxytocin with chronic dosing. The objective of the present study is to describe the design of a phase 2 adaptive randomised controlled crossover trial of intranasal oxytocin in frontotemporal dementia (FOXY) as an efficient model for future investigations of symptomatic treatments in neuropsychiatric and neurodegenerative disorders. Methods: Stage 1 will identify which of three dose schedules is most promising based on change in the primary outcome measure, the Neuropsychiatric Inventory apathy/indifference domain score, over 6 weeks of treatment. In stage 2, additional patients are enrolled at the most promising dose for preliminary efficacy analysis when combined with stage 1 to determine if a phase 3 trial is warranted. Objective measures include facial expression recognition, cerebrospinal fluid (CSF) oxytocin levels, and behavioural ratings of videotaped interactions. Results: A total of 20 patients per arm will be entered into stage 1 for a total of 60 patients. In stage 2, an additional 40 patients will be enrolled in the most promising dose arm. Conclusions: The use of adaptive, crossover designs and inclusion of objective measures of change in CSF oxytocin levels and social behaviour will improve the efficiency and conclusiveness of RCTs of oxytocin and other symptomatic treatments in neuropsychiatric disorders. Trial registration: ClinicalTrials.gov, NCT03260920 . Registered on August 24, 2017.
title: An evaluation of the proposal to regulate lead in hunting ammunition through the European Union's REACH regulation
title: An evaluation of the proposal to regulate lead in hunting ammunition through the European Union's REACH regulation
titleType: AlternativeTitle
Creators: name: Drost, Wiebke
name: Treu, Gabriele
Publisher: name: My University
Year: 2020
Subjects: Europäische Union
Jagd
REACH-System

description: Background Despite extensive evidence that exposure to lead from ingested ammunition harms humans and wildlife, and in contravention of European statesâ€Ì commitments under multilateral environmental agreements to minimize lead emissions, lead in hunting ammunition is still poorly regulated in Europe. The proposed restriction on lead gunshot under the REACH regulation is currently discussed for adoption to protect birds in wetlands from lead poisoning. Based on a subsequent investigation report concluding that additional measures are warranted to control the use of lead ammunition in terrestrial environments, ECHA is preparing a new restriction until October 2020. To help inform this process, we describe REACH management instruments and evaluate the effectiveness and enforceability of different legislative alternatives as well as socio-economic aspects of restricting lead shot in comparison to a total ban. We further discuss how the risks and environmental emissions of lead in rifle bullets can be most effectively controlled by legislative provisions in the future. Results Among different management tools, restriction was shown to be most effective and appropriate, since imports of lead ammunition would be covered. The partial restriction of lead gunshot limited to wetlands covers only a minor proportion of all lead used in hunting ammunition in the European Union, leaving multiple wildlife species at risk of being poisoned. Moreover, lead shot will be still purchasable throughout the EU. Within Europe, the costs associated with impacts on wildlife, humans and the environment would be considerably lower when switching to alternative gunshot and rifle bullets. Conclusion We argue that there is sufficient evidence to justify more effective, economic, and practical legislative provisions under REACH, i.e., restricting the use and placing on the market of lead in hunting ammunition. The enforcement would be significantly facilitated and hunters could easier comply. A crucial step is to define a realistic phasing-out period and chemical composition standards for non-lead substitutes while engaging all stakeholders to improve acceptance and allow adaptation. Until the total restriction enters into force, Member States could consider imposing more stringent national measures. A total restriction would reduce wildlife poisoning, harmonize provisions of national and European laws, and foster any efforts to decelerate loss of biodiversity. © The Author(s) 2020
Transitions in design education: a comparative study of Australian and Japanese interaction design education
Creators: name: Wang, Stephen Jia
name: Tamada, Toshiro
Publisher: name: Swinburne
Year: 2024

description: With ever-increasing pressure from technological and social changes to teach competence in interaction design, new teaching methods and syllabuses need to be explored. This study presents an approach to developing a syllabus that is focused on the cultural characteristics in interaction design. This study hypothesises that an international cross-cultural society will be the next shift to appear in the social structure. Working with this hypothesis, we applied comparative study methods to explore an Australian and Japanese interaction design educational practice and to analyse the theory and practice underpinning the current development of interaction design education. Most importantly, this study takes into account the cultural contexts that affect the interaction design characteristics in these two countries. Based on these findings, a design model sensitive to the cultural context in interaction design is proposed, which reflects the progressive transitions in interaction design education across these two countries.
Parryella rotundata Wooton, Bull. Torrey Bot.
Creators: name: Urrego, Paola Piñeros
name: Suárez-Barón, Harold
name: Pabón-Mora, Natalia
name: González, Favio
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Parryella
Parryella rotundata

description: Parryella rotundata Wooton, Bull. Torrey Bot. Club 25(8): 457 (1898).
Homotypic synonym= Errazurizia rotundata (Wooton) Barneby.
This transference adds a second species to Parryella, until now conformed by P. filifolia, and reduces from four to three the number of species of Errazurizia, namely E. benthamii, E. megacarpa and E. multifoliolata (Clos) I.M.Johnst.
3. Psorothamnus is paraphyletic, with species falling into two non-sister clades. One of the Psorothamnus subclades, including the type species of the genus (P. emoryi), results sister to Dalea + Marina, a result that receives the highest (100 %) bootstrap value in the partitioned ITS and the matK/trnK analyses, and the combined ITS + matK/trnK dataset. Altogether, this trigeneric assemblage is recovered as sister to a second Psorothamnus subclade with P. arborescens, P. fremontii, P. kingii, P. schottii, and P. spinosus. The bootstrap values that support the latter subclade range from 99 % in the ITS-based analysis to 100 % in the matK/trnK and the combined ITS + matK/ trnK analysis. All these species are former members of Psorodendron, a genus described as such in 1919 based on the type species P. johnsonii (= P. fremontii), making imperative its reinstatement. The genus Psorodendron was proposed originally by Rydberg (1919) as distinct from Psorothamnus based on the presence of pedicellate flowers and exserted pods in the former, versus sessile flowers and inserted pods in the latter. An updated description of the genus is here provided, based on all the species assigned to it, and described by Rydberg (1919, 1928a, 1928b), and Barneby (1977, under Psorothamnus sect. Capnodendron Barneby, P. sect. Xylodalea (S. Wats.) Barneby, and P. sect. Winnemucca Barneby).
description: Published as part of Urrego, Paola Piñeros, Suárez-Barón, Harold, Pabón-Mora, Natalia & González, Favio, 2023, Reinstatement of the genus Psorodendron and related systematic novelties as revealed from phylogenetic analyses of the tribe Amorpheae (Leguminosae, Papilionoideae), pp. 49-65 in Caldasia 45 (1) on page 57, DOI: 10.15446/caldasia.v45n1.96498, http://zenodo.org/record/15265087
A study of the reduction of organic halogen compounds by chromium(II) perchlorate.
Creators: name: Budzik, Joan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1960
Subjects: subject: Chemistry, Organic.

description: Phenacyl chloride was found to react with chromium(II) perchlorate, in the presence of methanol, to giver both acetophenone and o-methoxyacetophenone. In the presence of a large excess of methanol, the yield of o-methoxyacetophenone increased, and that of acetophenone decreased. If, on the other hand, the acid concentration of the methanolic solution was high, acetophenone was formed in over 80% yield, with trace amounts of o-methoxyacetophenone. In acetone, ethanol and t-butanol, reduction of phenacyl chloride gave mainly acetophenone. Chloroacetone was also found to yield o-methoxyacetophenone, when allowed to react with chromous ion in a large excess of methanol. The catalyzed solvolysis of alpha-haloketones, by chromium(II) perchlorate in methanolic solution, appears to have no known precedent. The reduction of methylene iodide with chromous ion did not take place in aqueous solution, but when methanol was used as solvent, iodomethylpentaaquochromium(III) perchlorate was formed. In the reduction of methylene bromide, bromomethylpentaaquochromium(III) perchlorate was obtained. Reduction of bromoform in methanol gave dibromomethylpentaaquochromium(III) perchlorate. It was found that when the halomethane contained both bromine and chlorine, attack took place preferentially at the bromine atom. In the reduction of bromodichloromethane, dichloromethylpentaaquochromium(III) perchlorate was formed, and the dibromochloromethane yielded bromochloromethylpentaaquochromium(III) perchlorate. The reduction of chloroform in 50% t-butanol-water was found to follow second order kinetics. Styrene dibromide on reduction was found to yield styrene as the sole organic product and Cr(H2O)5Br++ as the only inorganic product. The reduction of meso- and racemic 2,3-dibromobutane was found to be non-stereospecific, mixtures of cis and trans 2-butene being obtained when either isomer was reduced. The non-stereospecificity of this reduction suggests the possible presence of a radical intermediate, most probably a bromine atom, since such radicals are known to cause isomerization. This postulate is supported by the fact that cis-2-butene undergoes isomerization when present during the reduction of 1,2-dibromocyclohexane by chromous ion. The reduction of meso-2,3-dibromobutane in 50% t-butane-water and 75% t-butanol-water, and of racemic 2,3-dibromobutane in 50% t-butanol-water was found to follow second order kinetics. The reduction of 1,2-dibromo-2-methylpropane in 50% t-butanol-water was also found to be second order.
Fabrication and characterization of face-centered-cubic void dots photonic crystals in a solid polymer material
Creators: name: Zhou, Guangyong
name: Ventura, Michael J.
name: Vanner, Michael R.
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: Spherical void dots with a diameter of 1.2–1.8 µm have been generated in a solid polymer material by use of the ultrafast laser driven micro-explosion method. Micron-sized structures with a face-centered cubic lattice stacked in the [100] and [111] directions have been fabricated. Confocal microscopic images show the high uniformity of the fabricated structures. Photonic stopgaps with a suppression rate of approximately 70% as well as the second-order stopgaps have been observed in both directions. It is shown that the dependence of the stopgaps on the illumination angle in the [100] direction is significantly different from that in the [111] direction.
Supplementary document for Doubly resonant second-harmonic generation of a vortex beam from a bound state in the continuum - 4727525.pdf
Creators: name: WANG, Jun
name: Clementi, Marco
name: Minkov, Momchil
name: Barone, Andrea
name: Carlin, Jean-Francois
name: Grandjean, Nicolas
name: Gerace, Dario
name: Fan, Shanhui
name: Galli, Matteo
name: Houdré, Romuald
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document contains 2 supplementary sections and 2 individual figures (S3 and S4) that have been mentioned in the manuscript.
Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine
Creators: name: Krutzke, Lea
name: Rösler, Reinhild
name: Allmendinger, Ellen
name: Engler, Tatjana
name: Wiese, Sebastian
name: Kochanek, Stefan
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: nCov-19
subject: Vaccine dose
subject: DDC 610 / Medicine & health
subject: COVID-19 vaccines
subject: Mass spectrometry
subject: SARS-CoV-2
subject: Impfung
subject: Dosis
subject: Massenspektrometrie

description: ChAdOx1 nCov-19 and Ad26.COV2.S are approved vaccines inducing protective immunity against SARS-CoV-2 infection in humans by expressing the Spike protein of SARS-CoV-2. We analyzed protein content and protein composition of ChAdOx1 nCov-19 and Ad26.COV2.S by biochemical methods and by mass spectrometry. Four out of four tested lots of ChAdOx1 nCoV-19 contained significantly higher than expected levels of host cell proteins (HCPs) and of free viral proteins. The most abundant contaminating HCPs belonged to the heat-shock protein and cytoskeletal protein families. The HCP content exceeded the 400 ng specification limit per vaccine dose, as set by the European Medicines Agency (EMA) for this vaccine, by at least 25-fold and the manufacturer’s batch-release data in some of the lots by several hundred-fold. In contrast, three tested lots of the Ad26.COV2.S vaccine contained only very low amounts of HCPs. As shown for Ad26.COV2.S production of clinical grade adenovirus vaccines of high purity is feasible at an industrial scale. Correspondingly, purification procedures of the ChAdOx1 nCov-19 vaccine should be modified to remove protein impurities as good as possible. Our data also indicate that standard quality assays, as they are used in the manufacturing of proteins, have to be adapted for vectored vaccines.
"Civilizing" the Indian: Government administration of Indians, 1876-1896.
Creators: name: Boswell, Marion Joan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1977
Subjects: subject: History, Canadian.

description: During the twenty year period, 1876-1896, the Canadian government's racist and paternalistic administration of Indian Affairs east of the Rocky Mountains rested on the assumption that by following the five steps of pacification, containment, paternalistic management, education in practical skills and education in the ways of "civilization" it would be able to change reserve Indians. It would move them to the point where they, though still inherently inferior, would support themselves and live like non-Indians. The governments' objectives were changed in the seventies by their assumption of responsibility for the plains Indians. Nevertheless policy makers continued to believe that some eastern Indians who had taken the five steps would be ready to take a sixth and last step; they would give up their special status and become enfranchised. This thesis examines Department of Indian Affairs' implementation of the government's six steps. In the first section, chapters II and III, pacification of the Indians and the setting aside of reserves set the stage. The second section, chapters III, IV and V, examines the details of the 1876 Indian Act, one of the most significant milestones in the evolution of Indian policy and other legislation which applied to Indians. It then describes the organization and staff of the Department of Indian Affairs. In the third section, chapters VII, VIII and IX, the implementation of policies affecting Indian education, reserve economic and social life are described and evaluated in terms of the government's enunciated goals. The Conclusion considers the racism and paternalism of government Indian policies. It then assesses the degree to which the government had realized its goals by 1896 and lays some stress on the point that the government, although enunciating a desire to have Indians assimilate, wanted only a small minority to do so and intended that the majority would remain on their reserves. But by isolating the Indians on the reserves the government protected the Indian culture and allowed it to survive.