cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Retest reliability of repetitive transcranial magnetic stimulation over the healthy human motor cortex: a systematic review and meta-analysis
Creators: name: Kanig, Carolina
name: Osnabruegge, Mirja
name: Schwitzgebel, Florian
name: Litschel, Karsten
name: Seiberl, Wolfgang
name: Mack, Wolfgang
name: Schoisswohl, Stefan
name: Schecklmann, Martin
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: neuromodulation, cortical excitability, rTMS, variability, motor evoked potentials, reliability, protocols
subject: 610 Medizin

description: Introduction: Repetitive transcranial magnetic stimulation (rTMS) is used to induce long-lasting changes (aftereffects) in cortical excitability, which are often measured via single-pulse TMS (spTMS) over the motor cortex eliciting motor-evoked potentials (MEPs). rTMS includes various protocols, such as theta-burst stimulation (TBS), paired associative stimulation (PAS), and continuous rTMS with a fixed frequency. Nevertheless, subsequent aftereffects of rTMS are variable and seem to fail repeatability. We aimed to summarize standard rTMS procedures regarding their test–retest reliability. Hereby, we considered influencing factors such as the methodological quality of experiments and publication bias.

Methods: We conducted a literature search via PubMed in March 2023. The inclusion criteria were the application of rTMS, TBS, or PAS at least twice over the motor cortex of healthy subjects with measurements of MEPs via spTMS as a dependent variable. The exclusion criteria were measurements derived from the non-stimulated hemisphere, of non-hand muscles, and by electroencephalography only. We extracted test–retest reliability measures and aftereffects from the eligible studies. With the Rosenthal fail-safe N, funnel plot, and asymmetry test, we examined the publication bias and accounted for influential factors such as the methodological quality of experiments measured with a standardized checklist.

Results: A total of 15 studies that investigated test–retest reliability of rTMS protocols in a total of 291 subjects were identified. Reliability measures, i.e., Pearson's r and intraclass correlation coefficient (ICC) applicable from nine studies, were mainly in the small to moderate range with two experiments indicating good reliability of 20 Hz rTMS (r = 0.543) and iTBS (r = 0.55). The aftereffects of rTMS procedures seem to follow the heuristics of respective inhibition or facilitation, depending on the protocols' frequency, and application pattern. There was no indication of publication bias and the influence of methodological quality or other factors on the reliability of rTMS.

Conclusion: The reliability of rTMS appears to be in the small to moderate range overall. Due to a limited number of studies reporting test–retest reliability values and heterogeneity of dependent measures, we could not provide generalizable results. We could not identify any protocol as superior to the others.
Anacamptis pyramidalis (Linnaeus) Richard 1817
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Anacamptis
Anacamptis pyramidalis

description: 1. A. pyramidalis (L.) L. C. M. Richard, Orchid. Eur. Annot. 33 (1817) (Orchis pyramidalis L.). Stem 20-60(-75) cm, slender, with 2-3 brownish, sheathing basal scales. Lower leaves 8-25 cm, linear- to oblong-lanceolate, acute, canaliculate, entire, the upper smaller, or bract-like. Spike 2-8 cm, conical to shortly cylindrical, many-flowered; bracts linear-lanceolate. Flowers purplish-red, rarely pink or white. Perianth-segments 4-6 mm, subequal, broadly lanceolate, the outer median elliptic-ovate, concave. Labellum 6—8(—9) mm, broadly cuneate, the lobes c. 4 mm, subequal, oblong, more or less entire. Spur 12-14 mm, filiform, acute. 2n = 36. Grassland and scrub; calcicole. W., C. & S. Europe, extending northwards to the Baltic islands and eastwards to C. Ukraine. All except Az Fa Fe Is No Rs (N, E) Sb. Plants with small leaves and short spikes, from mountainous regions of the E. Mediterranean region, have been named var. brachystachys (D’Urv.) Boiss.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
UNDERSTANDING FETAL CIRCULATION AND THE TRANSITION TO POSTNATAL CIRCULATION: SHUNTS, PLACENTA AND CONGENITAL HEART DEFECTS
Creators: name: Abdumuminov, B.R.
name: Mohd Sajid, Arshad
Publisher: name: Zenodo
Year: 2023

description: Do you know how blood circulates within the fetus? Is the mother's blood mixed with the fetus's blood? If the mother has AIDS, why doesn't the fetus get infected with AIDS? Fetal circulation is an intriguing process that differs from blood circulation in adults. For instance, adult blood circulation involves two distinct circulatory systems: systemic circulation and pulmonary circulation. In contrast, fetal circulation exhibits a mixed blood circulation.
Additional file 1 of TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
Creators: name: Wang, Haiwei
name: Wang, Xinrui
name: Xu, Liangpu
name: Zhang, Ji
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Working process to analyze the prognosis of TP53 and its associated genes in paediatric neuroblastoma. Figure S2. Kaplan-Meier curves showed the different event free survival of paediatric neuroblastoma patients with TP53 higher expressions or lower expressions in TARGET, E-MTAB-161, E-MTAB-1781, E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 datasets. Figure S3. Kaplan-Meier curves showed the different event free survival of paediatric neuroblastoma patients with higher TP53 signaling pathway enrichment score or lower TP53 signaling pathway enrichment score in TARGET, E-MTAB-161, E-MTAB-1781, E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 datasets. Figure S4. Kaplan-Meier curves showed the prognosis of TP53 associated genes CCNE1, CDK2, CHEK2 and SESN1 in E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 datasets. Figure S5. The nomogram model could predict the overall survival of MYCN non-amplified paediatric neuroblastoma patients. (a) Kaplan-Meier curves showed the different overall survival of MYCN nonamplified paediatric neuroblastoma patients between low-risk sub-group and high-risk sub-group in TARGT, E-MTAB-161, E-MTAB-8248, E-TABM-38, GSE16476 and GSE49710 datasets. (c) The ROC curves showed the prediction of the three years, five years or ten years overall survival of MYCN non-amplified paediatric neuroblastoma.
Serapias L. 1753
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias

description: 29.Serapias L.1 Tubers 2-5, ovoid to globose, entire. Leaves narrow, canalicu­ late, acute, entire, usually shiny. Flowers in a spike. Outer perianth-segments ovate-lanceolate, acute, partially connate, connivent with the linear-lanceolate, acuminate inner lateral to form a galea. Labellum large, constricted into basal hypochile, with two indistinct lateral lobes, and prominent, pendent epichile. Spur absent. Column long. Rostellum small. Viscidium soli­ tary; bursicle simple. Literature: P. Christian, Quart. Bull. Alp. Gard. Soc. 43: 189-198 (1975). P. Gölz & H. R. Reinhard, Orchidee 28: 108-116 (1977). E. Nelson, Monographie und Ikonographie der Orchidaceen-Gattungen Serapias, Aceras, Loroglossum, Barlia. Chernez-Montreux. 1968. All species appear to hybridize readily with each other and with species of Anacamptis, Dactylorhiza, Ophrys and Orchis. 1 Epichile of labellum usually cordate, at least as wide as hypochile 2 Labellum with 2 divergent ridges at base; lateral lobes of hypochile c. i as wide as epichile; bracts shorter than flowers 1.cordigera 2 Labellum with 2 parallel ridges at base; lateral lobes of hypochile c. + as wide as epichile; bracts equalling or exceeding flowers 3 Epichile directed ±downwards 3.vomeracea 3 Epichile directed ± upwards or forwards 2.neglecta 1 Epichile of labellum narrowed towards base, narrower than hypochile 4 Bracts much exceeding flowers; lateral lobes of labellum reddish, black distally 3.vomeracea 4 Bracts equalling or slightly exceeding flowers; lateral lobes of labellum black or dark purple 5 Labellum with solitary black ridge at base, violet to reddish; tubers 2-5, 1 sessile, the others on stolons 4.lingua 5 Labellum with 2 ridges at base, brownish-red; tubers 2(-3), sessile 5.parviflora
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
Characterization of gas migration related to ethanol blended fuel spills and stray gas
Creators: name: Cocchetto, Danielle Lauren
Publisher: name: University of British Columbia
Year: 2023

description: Increased energy demand and technical advancements have led to unconventional resource development and alternative ethanol-blended fuel use. While these options are effective at contributing to meet energy demands, potential harmful effects due to release of constituents and degradation products into the environment must be considered to accurately assess risk and develop appropriate preventative, monitoring, and mitigation strategies. Gas migration and fate were studied in two related contexts: biodegradation of gasoline containing 20% ethanol (E20) and the release of stray gas into an aquifer. Secondary water quality impacts, vadose zone gas movement, and surficial release, were characterized, and effects of microbially-mediated reactions, porous media properties, and barometric pressure fluctuations were assessed. Two soil columns of differing permeability were used for each scenario. E20 fuel spill analysis included measurement of CO₂ and CH₄ surface efflux, soil gas concentrations (O₂, CH₄, CO₂, N₂, Ar, benzene, and toluene), volatile fatty acids, alkalinity and pH, cations, and aqueous benzene, toluene, and ethanol concentrations. Assessment of stray gas migration involved CO₂ and CH₄ surface efflux, soil gas concentrations (O₂, CH₄, CO₂, N₂, Ar), isotopic analysis (δ¹³C-CO₂, δ¹³C-CH₄, δ²H-CH₄), barometric pressure, hydraulic heads, and mass flow rates. Results reveal significant impacts on gas migration attributable to soil type in both cases. E20 fuel release resulted in greater aerobic oxidation of ethanol and the petroleum products in higher permeability soil. Microbial toxicity was not found to impede biodegradation in the buffered system; however, Mn²⁺ and Fe²⁺ metal release was observed. Two different flow experimental conditions were considered for the stray gas experiments: Stray gas release subject to constant flow rate or under constant pressure conditions. Stray gas migration was observed to be continuous under constant mass flow conditions, while dominantly discontinuous flow was seen under constant pressure conditions. Discontinuity of gas flow was found to be correlated with barometric pressure fluctuations, with more pronounced effect in finer grained soil. Under both release conditions, substantial methane (CH₄) oxidation was observed; however, the fraction of CH₄ oxidized declined for higher stray gas release rates. Irrespective of the nature of gas release, CH₄ and CO₂ were released across both column surfaces.
Open Data for Humanists, A Pragmatic Guide
Creators: name: Edmond, Jennifer
name: Tóth-Czifra, Erzsébet
Publisher: name: Zenodo
Year: 2018
Subjects: Open data
Research data management
Open Access
Arts and Humanities
Cultural Heritage

description: In the arts and humanities, digital data production is still expensive, challenging and time-consuming. We all know this, and yet the results of these processes often in the end can’t be reused by other researchers, meaning that we reinvent (or redigitise) the wheel far too often. This resource is aimed at giving practical advice for arts and humanities scholars who are willing to take their first steps in research data management but don't know where to begin. Our approach to data management views it as a reflective process that exposes and tweaks existing behaviours, rather than one that introduces specific tools. It is intended to encourage awareness of one’s own processes and mindfulness about how they could be more open and how and how small changes across three points in your research workflow can make big differences.
Competitive Relationships Between Sugar and Corn Sweeteners
Creators: name: Jones, Phillip E.
name: Thomason, F. G.
name: Jones, Phillip E.
name: Thomason, F. G.
Publisher: name: Unknown
Year: 1951
Subjects: Agricultural and Food Policy
Demand and Price Analysis
Food Consumption/Nutrition/Food Safety
Productivity Analysis

description: This study is confined to an analysis of the competition between sweeteners used industrially in making bakery products, ice cream, confectionery, soft drinks, and canned, frozen, or preserved foods. It is estimated that in 1949 approximately 94 percent of the sugar which was used for the commercial production of sweetened foods was used in these products. Except for corn sirup used in blended sirups, even larger proportions of the corn sweeteners were used in these products. No attention has been given in this study to the use of sweeteners for making any of these products in the home, nor to direct household or restaurant consumption of sugar and corn sirup. While the primary sweeteners under study here are the various types of sugar and corn sweeteners, some mention will be made of other sweeteners, such as molasses and honey. An analysis is made of how each of the three types of corn sweeteners--dextrose, corn sirup, and corn sirup solids--competes with sugar, and attention is given to the effect upon this competitive pattern of utilizing sugar in liquid rather than in crystalline form. The primary objectives of this study are twofold: (1) To determine statistically the extent of competition between sugar and the corn sweeteners in the production of processed foods; and (2) to ascertain the principal factors governing an industrial user's choice of sweetening agent or agents in making a given product.
„Plädoyer für einen mehrdimensionalen Beratungsansatz in der klinischen Ethikberatung“
Creators: name: Vogel, Lars
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Serapias cordigera L. 1763
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias cordigera

description: 1. S. cordigera L., Sp. PI. ed. 2, 1345 (1763). Tubers 2-3, 1 sessile, the other(s) on stolons, ovoid to globose. Stem 15-50 cm, with purplish, usually spotted basal sheaths. Spike short, ovoid, dense, 2- to 10-flowered; bracts shorter than flowers, purplish. Flowers 20-35 mm; outer perianth-segments subequal, ovate- lanceolate, acuminate, free at apex, purple, rarely white; inner lateral about as long as the outer. Labellum twice as long as the other segments, with two deep purple to black divergent ridges at base; lateral lobes purplish-black, rarely pink or white, rounded, partly hidden by galea; epichile as wide as hypochile, acuminate, hairy, reddish-purple, with darker veins, rarely yellowish. 2n = 36. Open woodland and scrub, grassland and stream-margins. S. & W. Europe, northwards to N. W. France. Al Au Az B 1 Co Ga Gr Hs It Ju Lu Sa Si Tu.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
Autor_innenverzeichnis
Creators: name: Forum Supervision-Autor*Innen, Herausgeber*In Und Redaktion
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Flyer zum Start des 8. Kurses des Masterstudiengangs „Supervision und Beratung“
Creators: name: Forum Supervision-Masterbüro „Supervision Und Beratung"
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Serapias azorica Schlechter 1923
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias azorica

description: S. azorica Schlechter, Feddes Repert. 19: 44 (1923), described from Açores (San Miguel), is said to differ from 1 in having the epichile distinctly wider than the hypochile and smaller flowers in a shorter spike. These characters are found in high altitude variants of 1 in the Açores, plants at lower elevations having larger flowers; they do not merit formal recognition above varietal status.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
Surface interactions between chitin nanocrystals and an anionic surfactant : from fundamentals to applications
Creators: name: Su, Xiaoya
Publisher: name: University of British Columbia
Year: 2023

description: We elucidate the interactions between positively charged chitin nanocrystals (ChNC) and an anionic surfactant, sodium dodecyl sulfate (SDS), and report on their role in the stabilization of Pickering emulsions. ChNC/SDS interactions were systematically investigated by using electrophoretic mobility, surface tensiometry, and quartz crystal microgravimetry. The results indicate that SDS molecules undergo different regimes when adsorbing on the chitin nanoparticles. At low SDS concentration, a monolayer is assembled on the surface of ChNC, attributed to the hydrophobic effect and electrostatic interactions. We suggest that with the increased SDS concentration, adsorption in the form of bilayer or patchy bilayers occurs followed by the formation of adsorbed hemi-micelles and micelles. We further suggest that hydrophobic interactions play a critical role in defining the transitions presented by the adsorbed species and their conformations. At the highest SDS concentrations tested, we observe charge neutralization and flocculation, in the form of SDS/ChNC aggregates. Remarkably, at given concentrations, the adsorbed SDS introduces hydrophobicity to the chitin nanoparticles, which opens the opportunity to achieve tailorable conditions for Pickering stabilization. Hence, a facile method is proposed by in-situ surface modification, using the physical adsorption of SDS on ChNC, which extends the potential of renewable nanoparticles in the area of complex fluids, for instance, in the formulation of household and healthcare products.
Ganz normale Organisationen
Creators: name: Bauer, Annemarie
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Serapias neglecta De Notaris 1844
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias neglecta

description: 2. S. neglecta De Not., Repert. FI. Ligust. 423 (1844). Tubers 2, sessile, ovoid to globose. Stem 10-30 cm, with green, unspotted basal sheaths. Spike short, dense, 2- to 8-flowered; bracts equalling or slightly exceeding flowers, green, often tinged with purple. Flowers 25-40 mm; outer perianth-segments ovatelanceolate, acuminate, concave, free at apex, lilac; inner lateral slightly shorter than the outer. Labellum c. 3 times as long as the other segments, with two dark purple parallel ridges at base; lateral lobes rounded, red or purplish, partly hidden by galea; epichile as wide as hypochile, cordate, acuminate, hairy, pale to deep yellow, rarely orange. Damp grassland, on sandy soils, usually coastal. C. Mediterranean region. Co Ga Gr It Ju Sa?Si.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
Supervision auf dem Prüfstand
Creators: name: Maier-Sonnleitner, Chritopher
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Fallsupervision
Creators: name: Gröning, Katharina
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
title: Τα Μικροκυστίδια ως νέος βιοδείκτης στους ασθενείς με Θρομβοφιλία
title: Microvesicles as a new biomarker for patients with Thrombophilia
titleType: AlternativeTitle
Creators: name: Καραμάνη, Χριστίνα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Θρομβοφιλία
Αιμόσταση
Διαταραχές Αιμόστασης
Βιοδείκτες
Μικροκυστίδια

description: Οι διαταραχές στην αιμόσταση, ιδίως η Θρομβοφιλία, περιλαμβάνουν μία ευρεία γκάμα παθολογικών καταστάσεων κατά τη διάρκεια των διαδικασιών της πήξης και ινωδόλυσης, θέτοντας σημαντικές προκλήσεις στην κλινική διάγνωση και αντιμετώπιση. Η εύρεση και ο προσδιορισμός αξιόπιστων βιοδεικτών είναι ζωτικής σημασίας για την ακριβή αξιολόγηση, παρακολούθηση της εξέλιξης της νόσου και την εξατομίκευση και εύρεση θεραπευτικής αγωγής. Τα τελευταία χρόνια έχουν πραγματοποιηθεί έρευνες για ένα νέο, υποσχόμενο διαγνωστικό εργαλείο όπου θα βοηθήσει στη μη επεμβατική διάγνωση της Θρομβοφιλίας, τα μικροκυστίδια. Τα μικροκυστίδια αποτελούν μικρές κύστες που απελευθερώνονται από τη μεμβράνη των κυττάρων στην κυκλοφορία κατά την ενεργοποίηση ή την απόπτωση. Προέρχονται από διάφορους τύπους κυττάρων ,όπως τα αιμοπετάλια, τα ενδοθηλιακά και τα λευκοκύτταρα. Μεταφέρουν φορτίο από πρωτεΐνες, νουκλεϊκά οξέα και λιπίδια τα οποία αντικατοπτρίζουν και την προέλευση τους ,το είδος κυττάρου από όπου και απελευθερώνονται. Τα βιομόρια αυτά μπορούν να παρέχουν πολύτιμες πληροφορίες για τις υποκείμενες παθοφυσιολογικές διαδικασίες που συνδέονται με τη Θρομβοφιλία. Η παρούσα εργασία αποσκοπεί στη διερεύνηση των δυνατοτήτων των μικροκυστιδίων ως βιοδείκτες για τη θρομβοφιλία, εξετάζοντας τη συσχέτισή τους με τα κλινικά αποτελέσματα και το ρόλο τους στις συναφείς επιπλοκές στο πλαίσιο των θρομβωτικών διαταραχών.
Composition dependency of the Flory–Huggins interaction parameter in drug–polymer phase behavior
Creators: name: Klüppelberg, Jana
name: Handge, Ulrich A.
name: Thommes, Markus
name: Winck, Judith
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: Formulation design
subject: Phase diagrams
subject: Solubility
subject: Glass transition
subject: Flory–Huggins theory
subject: 660

description: An innovative strategy to address recent challenges in the oral administration of poorly soluble drugs is the formulation of amorphous solid dispersions (ASDs), where the drug is dissolved in a highly soluble carrier polymer. Therefore, special knowledge of the drug–polymer phase behavior is essential for an effective product and process design, accelerating the introduction of novel efficacious ASD products. Flory–Huggins theory can be applied to model solubility temperatures of crystalline drugs in carrier polymers over the drug fraction. However, predicted solubility temperatures lack accuracy in cases of strong drug/polymer interactions that are not represented in the Flory–Huggins lattice model. Within this study, a modeling strategy is proposed to improve the predictive power through an extension of the Flory–Huggins interaction parameter by a correlation with the drug fraction. Therefore, the composition dependency of the Flory–Huggins interaction parameter was evaluated experimentally for various drug–polymer formulations that cover a wide variety of drug and polymer characteristics regarding molecular weights, glass transition temperatures and melting temperatures, as well as drug–polymer interactions of different strengths and effects. The extended model was successfully approved for nine exemplary ASD formulations containing the drugs acetaminophen, itraconazole, and griseofulvine, as well as the following polymers: basic butylated methacrylate copolymer, Soluplus®, and vinylpyrrolidone/vinyl acetate copolymer. A high correlation between the predicted solubility temperatures and experimental and literature data was found, particularly at low drug fractions, since the model accounts for composition dependent drug–polymer interactions.
description: Pharmaceutics;Vol. 15. 2023, 12, Art.ID 2650
Veränderung erzeugt Widerstand
Creators: name: Walpuski, Volker
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Cora Baltussen in den USA
Creators: name: Walpuski, Volker
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Das Werk des Soziologen Erving Goffman als Wissenssystematik für die Supervision in der Psychiatrie
Creators: name: Friesel-Wark, Heike
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Moderation - Seelsorge - Supervision im klinischen Feld der Ethikberatung
Creators: name: Kessler-Weinrich, Angela
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Vom ethischen Dissens zum moralischen Dilemma und zurück
Creators: name: Dieringer, Volker
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Serapias vomeracea (Burman) Briquet 1910
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias vomeracea

description: 3. S. vomeracea (Burm.) Briq., Prodr. FI. Corse 1: 378 (1910) (S. longipetala (Ten.) Pollini, S. pseudocordigera Moric.). Tubers 2, ovoid, sessile. Stem (5-)10-55 cm, with green, un­ spotted basal sheaths. Spike 2- to 10-flowered; bracts pale red, with darker veins. Flowers 15-30 mm; perianth-segments sub­ equal, pale red, with darker veins, the outer lanceolate, acumi­ nate, free at apex, the inner ovate-lanceolate. Labellum 11 /2times as long as the other segments, with 2 pale, slightly divergent ridges at base; lateral lobes rounded, sometimes erect, reddish, black distally, partly hidden by galea; epichile triangular-lanceolate, acute, narrowed at base, narrower than hypochile, hairy, reddish or brownish, rarely white. 2n = 36. Woodland, scrub and grassland. S. Europe. A 1 B 1 Bu Co Cr Ga Gr He Hs It Ju Lu Sa Si Tu.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
Investigating the effects of expressing MECP2 in Saccharomyces cerevisiae
Creators: name: Ling, Yeou Mei
Publisher: name: University of British Columbia
Year: 2023

description: Methyl-CpG-binding protein 2 (MECP2) plays a key role in brain homeostasis. MECP2 function is sensitive to changes in its concentration, as both overexpression and reduction of MECP2 result in neurodevelopmental disorders in humans and mice. MEPC2 was originally discovered based on its ability to bind methylated-CpG DNA to repress gene expression. Later research suggested that MECP2 may also interact with unmethylated DNA. While there have been in vitro studies supporting this idea, there were few in vivo studies. In this thesis, we demonstrate that expression of the human MECP2 in an organism lacking DNA methylation, the budding yeast Saccharomyces cerevisiae, disrupts normal yeast growth, by inhibiting passage through S phase. Further investigation revealed that MECP2-expressing yeast had defects in their cell cycle, which may be the cause of the growth defect. We found that the phenotype of yeast expressing MECP2 with disease-associated mutations reflects disease severity in humans. Using single-cell techniques such as flow cytometry and fluorescence microscopy, we confirmed the expression of MECP2 in yeast and its nuclear localization. Disease-associated mutations that reversed the growth defect either impair nuclear localization or, as previously reported, disrupt MECP2 binding to DNA. In addition, we found differences between the two MECP2 isoforms in terms of protein stability, and impact on the cell cycle and viability. This suggests that the isoforms have different functions and potentially, differing interacting partners within cells. Collectively, our findings confirmed the feasibility of using yeast as a model organism to study MECP2 function in vivo. Moreover, using this system, we are able to rapidly screen for phenotypes of MECP2-disease-associated mutations that reflect disease severity in humans.
Plädoyer für einen mehrdimensionalen Beratungsansatz in der klinischen Ethikberatung
Creators: name: Stets, Hans-Jörg
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Vorwort
Creators: name: Forum Supervision-Herausgeber*In Und Redaktion
Publisher: name: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision
Year: 2021

description: FoRuM Supervision - Zeitschrift für Beratungswissenschaft und Supervision, 2021: Heft 56 - Ethische Fallbesprechung
Additional file 4 of Common mouse models of tauopathy reflect early but not late human disease
Creators: name: Wenger, Kathrin
name: Viode, Arthur
name: Schlaffner, Christoph N.
name: van Zalm, Patrick
name: Cheng, Long
name: Dellovade, Tammy
name: Langlois, Xavier
name: Bannon, Anthony
name: Chang, Rui
name: Connors, Theresa R.
name: Oakley, Derek
name: Renard, Bernhard
name: Rappsilber, Juri
name: Hyman, Bradley
name: Steen, Hanno
name: Steen, Judith A.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 4. Figure S4. Analysis of the quantitative modification extent (FLEXITau) and Pearson correlation identify regions and modifications of Tau that drive pathology in both models and human AD. A, C Euclidean hierarchical clustering of relative amounts of unmodified FLEX-peptide of pathological Tau derived from the P301S brain stem (A) and subcortical region (C). B, D Euclidean hierarchical clustering of relative amounts of unmodified FLEX-peptide of pathological Tau derived from the P301L hippocampus (B) and subcortical region (D). E Average relative amounts of unmodified FLEX-peptides per condition from pathological Tau derived from the P301S brain stem and subcortical region and the P301L hippocampus and subcortical region ordered from N- to C-terminus. F Pearson correlation between the amount of unmodified FLEX-peptide and logarithmic amount of pathological Tau ordered from N- to C-terminus for the P301S brain stem and subcortical region and the P301L hippocampus and subcortical region.A legend is provided for the extent of modification and the Pearson correlation coefficient of each peptide. And the in average top 5 correlating peptides.
Serapias vomeracea subsp. vomeracea (Burm.) Briq. 1910
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias vomeracea
Vomeracea

description: (a) Subsp.vomeracea: Stem up to 55 cm. Spike elongate, lax, 3- to 10-flowered. Bracts much exceeding flowers. Outer median perianth-segments directed upwards. Labellum with middle lobe 9-11 mm wide. Throughout the range of the species except for parts of the south-east.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 343, DOI: 10.5281/zenodo.215522
Book reviews - Buchbesprechungen
Creators: name: Brunnacker, Karl
name: Adam, Karl Dietrich
name: Kraft, Ingo
name: Guenther, Ekke W.
name: Züchner, Christian
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Rezension zu: Klostermann, J.: Das Quartär der Niederrheinischen Bucht; Ablagerungen der letzten Eiszeit am Niederrhein. 200 S., 30 Abb., 8 Tab., 2 Taf., Krefeld (Geologisches Landesamt Nordrhein-Westfalen), 1992. Rezension zu: Ian Tattersall, Eric Delson & John van Couvering (Ed.): Encyclopedia of Human Evolution and Prehistory. XXXVI + 603 S. zahlreiche Abb., Tab., Karten, Profile & Diagramme. New York & London: Garland Publishing 1988. (Garland Reference Library of the Humanities, Vol. 768.) Rezension zu: Miklós Kretzoi und Viola T. Dobosi (Ed.), mit Beiträgen von V. V. Cherdintsev u. I. V. Kazachevski, Ian Wn Cornwall, Kurt Diebel u. Erika Pietrzeniuk, Viola T. Dobosi, Ernö Horváth, Dénes Jánnossy, Magda Járai-Komlódi, Miklós Kretzoi, Endre Krolopp, Loránd Moldvay, Kenneth P. Oakley, J. K. Osmond, Márton Pécsi, Gyla Scheuer u. Ferenc Schweitzer, H. P. Schwarcz u. A. G. Latham, István Skoflek, Andor Thoma, Klára Varga-Máthé, László Vértes: Vértesszölös. Man, Site and Culture (Translated by Alice M. Choyke, Magdaléna Seleanu u. Katalin Simán). 555 S., 143 Abb., 27 Tab., 108 Taf. u. 8 Beil. Akadémiai Kiadó, Budapest 1990. Rezension zu: Ralf Busch u. Hermann Schwabedissen (Hrsg.): Der eiszeitliche Fundplatz Salzgitter-Lebenstedt. Teil ll. Naturwissenschaftliche Untersuchungen. 231 S., 57 Abb., 11 Tab., 26 Taf., Köln, Weimar, Wien 1991. Rezension zu: Brigitte und Gilles Delluc: L'art pariétal archaïque en Aquitaine. 393 S. mit 235 Abb. im Text. XXVIIIe supplément à Gallia Préhistoire, Paris 1991.
description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
Die 34. Tagung der Hugo Obermaier-Gesellschaft in Hannover 1992 mit Exkursionen in das Hannoversche Wendland und südliche Harzvorland
Creators: name: Uthmeier, Thorsten
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
Development of a spatial decision support framework for risk assessment of oil and gas pipelines exposed to external pitting corrosion
Creators: name: Woldesellasse, Haile
Publisher: name: University of British Columbia
Year: 2023

description: This dissertation proposes a comprehensive decision support framework for risk assessment of oil and gas pipelines exposed to external pitting corrosion. The study begins by performing a bibliometric analysis to identify the top cited research publications on this area. After that, several imputation and class imbalance handling techniques are proposed to handle the missing values and class imbalance that are frequently observed problems in a corrosion dataset. The usefulness of both proposed techniques was assessed using a neural network model. The model's prediction performance improved when it was trained using the cleaned corrosion dataset. Then, the risk assessment framework is developed using the corrosion dataset in a bow-tie approach, which represents an entire accident scenario starting with causes and ending with consequences. The proposed framework was developed by integrating Bayesian belief network (BBN) with a geographic information system (GIS). The framework part for evaluating the failure probability of buried pipelines is developed using three basic components: corrosion model, failure pressure model, and limit state function to estimate the probability of failure due to burst and leak. Lastly, the framework part for evaluating the consequence assessment is developed using an existing event tree and additional factors including failure probability of a pipeline, igniting probability, population density, and the presence of protected or conserved areas. The consequence of gas pipeline failure are assessed based on casualty and environmental impact. The reasoning power of the BBN and the spatial capability of the GIS combine to form a powerful tool to aid decision makers manage a spatially distributed aging pipeline. Additionally, it aids pipeline operators in making timely, and cost-effective decisions to avoid accidents in high consequence areas.
D.E.P. weekly bulletin 1979 July - September
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1979

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Serapias vomeracea subsp. orientalis W. Greuter 1972
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias vomeracea
Orientalis w. greuter

description: (b) Subsp.orientalis W. Greuter, Florist. Rep. Cretan Area 19 (1972) : Stem not more than 25(-30) cm. Spike short, rather dense, (2-)3- to 4(-6)-flowered. Bracts equalling or slightly exceeding flowers. Outer median perianth-segments horizontal. 1 By D. M. Moore. Labellum with middle lobe 11-23 mm wide. E. Mediterranean region. Plants from the E. Mediterranean region, here included in subsp. (a), have been distinguished as subsp.laxiflora (So6) Gölz & Reinhard, Orchidee 28: 114 (1977) (S.parviflora subsp.laxiflora Soö, S. columnae (Ascherson & Graebner) Fleischm., S. hellenica Renz), on account of their shorter perianth-segments and labellum, narrower hypochile and often reflexed epichile.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on pages 343-344, DOI: 10.5281/zenodo.215522
Die 33. Tagung der Hugo Obermaier-Gesellschaft 1991 in Blaubeuren mit Exkursionen in den Hegau und auf die Schwäbische Alb
Creators: name: Gohlisch, Torsten Harri
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
PATIENT-CENTERED MEDICAL HOMES AND DIABETES OUTCOMES: AN INTEGRATED LITERATURE REVIEW
Creators: name: Glenmore Hendricks
Publisher: name: Zenodo
Year: 2015

description: Driven by the need to improve patient quality outcomes—while providing efficient and cost effective care—many healthcare systems have adopted the transformational model, patient centered medical home (PCMH), to managed patients with chronic diseases. This integrated literature review provides a critical appraisal of the evidence relating to diabetes care in PCMH settings, along with evidence syntheses. The review and syntheses are guided by the Agency for Healthcare Quality and Research (AHRQ) framework for PCMH. 96 studies were systematically retrieved from the relevant databases of the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, Cochrane Review, Academic Premier (EBSCO), and PsychINFO. Only empirical studies published in English between 2003 and 2014 were included. 84 studies were eliminated for not meeting the criteria, leaving 12 studies for further analysis. The findings suggest that current evidence on the efficacy of the PCMH model in diabetes mellitus (DM) outcomes is equivocal. Only five studies reported improved quality outcomes, four studies showed improved process outcomes, and the remaining three studies showed no improvement in either measure for DM care in the PCMH setting. Where there were successful implementations of the PCMH model, they were supported by dedicated workflows, a consistent approach to care delivery, and teams that are well-managed. The limitations of the review included findings that were not generalizable, heterogeneous study designs, lack of comparison groups and non- iv randomized comparison practices. Future studies need to consider longitudinal designs, in which the PCMH’s effect on diabetes outcomes can be observed over time.
Serapias lingua Linnaeus 1753
Creators: name: D. M. Moore (Ed.)
Publisher: name: Zenodo
Year: 1980
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Serapias
Serapias lingua

description: 4. S. lingua L., Sp. PI. 950 (1753). Tubers 2-5, 1 sessile, the others on stolons, ovoid to subglobose. Stem 10-25(-60) cm, with green, unspotted basal sheaths. Spike elongate, 2- to 9- flowered; bracts equalling flowers, purple, rarely greenish. Flowers 15-25 mm; outer perianth-segments ovate-lanceolate, acute, concave, free at apex, violet or purple, rarely white, some­ times with greenish markings; inner lateral slightly shorter than the outer. Labellum about twice as long as the other segments, with solitary black ridge at base; lateral lobes rounded, dark purple, hidden by galea; epichile ovate-lanceolate, acuminate, narrowed at base, narrower than hypochile, sometimes directed forwards, violet to reddish, rarely yellow or white. Damp grassland, marshes and maritime sands. Mediterranean region and S. W. Europe. A 1 B 1 Co Cr Ga Gr Hs It Ju Lu Sa Si.
description: Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 344, DOI: 10.5281/zenodo.215522
Zur Fauna der Fundstelle Metternich aus dem mittleren Jungpaläolithikum
Creators: name: Guenther, Ekke W.
name: Musil, Rudolf
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
Additional file 1 of Effect of occlusal coverage depths on the precision of 3D-printed orthognathic surgical splints
Creators: name: Wang, Yipeng
name: Wang, Peiqi
name: Xiang, Xiang
name: Xu, Hui
name: Tang, Yuting
name: Zhou, Yumeng
name: Bai, Ding
name: Xue, Chaoran
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Mental Health

description: Additional file 1. P-values for paired comparison of the deviations.
Consumers' Use of and Opinions about Citrus Products
Creators: name: Bayton, James A.
name: Meyers, Trienah
name: Goldhammer, Margaret
name: Bayton, James A.
name: Meyers, Trienah
name: Goldhammer, Margaret
Publisher: name: Unknown
Year: 1951
Subjects: subject: Crop Production/Industries
subject: Food Consumption/Nutrition/Food Safety
subject: Marketing
subject: FOS: Economics and business

description: The purpose of this survey was to provide information that would be helpful in promoting the consumption of the major citrus crops. The results contain data which should be of value to all who are concerned with the production and marketing of these products, with subsequent benefit to consumers. It would have been desirable to explore intensively the consumer's use of and attitudes toward all of the citrus products, but this would have been impracticable within a single interview. To escape this difficulty data were obtained on general use of all citrus products and intensive information was restricted to those products that were considered as being the most important to the citrus industry. These latter products were fresh oranges and grapefruit and lemons; frozen concentrated orange juice; canned orange juice, grapefruit juice, orange and grapefruit juice blends (canned blends), and lemon juice. Products, in addition to the above, for which data on general use were obtained were fresh limes and tangerines; frozen concentrated grapefruit juice, frozen concentrated orange and grapefruit blend, and frozen grapefruit segments; canned lime juice, tangerine juice, orange segments, grapefruit segments, and mixed orange and grapefruit segments.
The Messum/Menongue Complex: Early Holocene stone tool assemblages in Namibia and Angola
Creators: name: Richter, Jürgen
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
Raw data files
Creators: name: Hoheneder, Felix
Publisher: name: figshare
Year: 2022
Subjects: subject: 70308 Crop and Pasture Protection (Pests, Diseases and Weeds)
subject: FOS: Agriculture, forestry and fisheries

description: Raw data on fungal DNA, Fusarium mycotoxins, weather conditions and plant height of barley genotypes used in the study
Host Genotype and Weather Effects on Fusarium Head Blight Severity and Mycotoxin Load in Spring Barley
by Hoheneder et al. 2022
Ein Mondkalenderstab aus Dolní Věstonice
Creators: name: Emmerling, E.
name: Geer, H.
name: Klíma, Bohuslav
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
Zur Häufigkeit von Abschlägen mit facettiertem Schlagflächenrest in vor-jungpaläolithischen Inventaren
Creators: name: Schäfer, Dieter
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 43/44 (1993): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung