cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evolutions from extremality
Creators: name: Booth, Ivan
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine the evolution of extremal spherically symmetric black holes, developing both general theory as well as the specific cases of (charged) null dust and massless scalar field spacetimes. As matter accretes onto extremal marginally trapped tubes, they generically evolve to become non-extremal with the initial extremal horizon bifurcating into inner and outer non-extremal horizons. At the start of this process arbitrarily slow matter accretion can cause a geometrically invariant measure of horizon growth to jump from zero to infinity. We also consider dynamical horizons that are extremal throughout their evolution and see that such spacetimes contain two extremal black hole horizons: an inner isolated one and an outer dynamical one. We compare these extremal dynamical horizons with the dynamical extreme event horizon spacetimes of Murata, Reall and Tanahashi.
description: V3: Version accepted to PRD. Significant new material including a full analysis of junction conditions for dynamical extremal horizons (an instantaneous thin shell is now identified). Other smaller changes including extra material to clarify some points as well as fixing minor errors and typos. References added. Now 14 pages and 7 figures
ปัจจัยที่ส่งผลต่อความตั้งใจใช้แนวคิดการพัฒนาซอฟต์แวร์แบบ DevOps
Creators: name: สนิธพรรณ  จิตตั้งสมบูรณ์
Publisher: name: โรงพิมพ์แห่งจุฬาลงกรณ์มหาวิทยาลัย
Year: 2018
Subjects: ระเบียบวิธีการพัฒนาซอฟต์แวร์
DevOps
แอจไจล์
ปัจจัยความสำเร็จ
ทฤษฎีความเข้ากันได้ระหว่างงานกับเทคโนโลยี
ทฤษฎีการยอมรับเทคโนโลยี
การรับรู้ความสามารถตนเอง
Software Development Methodology
Agile
Critical success factor
Task-Technology-Fit
Technology Acceptance Model
Self-efficacy

description: จุฬาลงกรณ์ธุรกิจปริทัศน์, 40, 158, 53-110
Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis
Creators: name: Sha, Yonggang
name: Markovic-Plese, Silva
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naive and memory CD4+ T cells derived from relapsing-remitting multiple sclerosis (RR MS) patients in comparison to healthy controls. Interleukin 1 receptor (IL-1R)I expression is upregulated in the in vitro-differentiated Th17 cells from RR MS patients in comparison to the Th1 and Th2 cell subsets, indicating the role of IL-1R signaling in the Th17 cell differentiation in RR MS. When IL-1RI gene expression was silenced using siRNA, human naive CD4+ T cells cultured in the presence of Th17-polarizing cytokines had a significantly decreased expression of interleukin regulatory factor 4 (IRF4), RORc, IL-17A, IL-17F, IL-21, IL-22, and IL-23R genes, confirming that IL-1RI signaling induces Th17 cell differentiation. Since IL-1R gene expression silencing inhibited IRF4 expression and Th17 differentiation, and IRF4 gene expression silencing inhibited Th17 cell differentiation, our results indicate that IL-1RI induces human Th17 cell differentiation in an IRF4-dependant manner. Our study has identified that IL-1RI-mediated signaling pathway is constitutively activated, leading to an increased Th17 cell differentiation in IRF4-dependent manner in patients with RR MS.
Characterizing interactions in online social networks during exceptional events
Creators: name: Omodei, Elisa
name: De Domenico, Manlio
name: Arenas, Alex
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Nowadays, millions of people interact on a daily basis on online social media like Facebook and Twitter, where they share and discuss information about a wide variety of topics. In this paper, we focus on a specific online social network, Twitter, and we analyze multiple datasets each one consisting of individuals' online activity before, during and after an exceptional event in terms of volume of the communications registered. We consider important events that occurred in different arenas that range from policy to culture or science. For each dataset, the users' online activities are modeled by a multilayer network in which each layer conveys a different kind of interaction, specifically: retweeting, mentioning and replying. This representation allows us to unveil that these distinct types of interaction produce networks with different statistical properties, in particular concerning the degree distribution and the clustering structure. These results suggests that models of online activity cannot discard the information carried by this multilayer representation of the system, and should account for the different processes generated by the different kinds of interactions. Secondly, our analysis unveils the presence of statistical regularities among the different events, suggesting that the non-trivial topological patterns that we observe may represent universal features of the social dynamics on online social networks during exceptional events.
Synoptic Wide-field e-MERLIN EVN Programme
Creators: name: Herbe-George, Célestin
Publisher: name: Zenodo
Year: 2023

description: The high angular resolution and sensitivity of VLBI offers a unique tool to identify and study AGN and star-formation activity over cosmic time. VLBI observations are crucial for identifying young radio sources and unveiling older restarted radio sources. Also, radio imaging over a large range of angular scales is needed to determine the role of black hole feedback and jet-induced star formation in galaxies. To answer these questions and to find rare radio sources, such as gravitational lenses and binary/dual AGN, all-sky VLBI surveys are needed. Despite recent technical advances, such as multiple phase centre correlation and multi-source self-calibration, only a limited part of the sky has been observed within a few well-studied fields (e.g. Lockman Hole, HDF, GOODS-N, COSMOS, SPARCS-N). To enter the realm of large statistical studies, a significantly larger area of sky must be observed, which would limit the VLBI available time for other single-target science projects.
 SWEEPs (Synoptic Wide-field e-MERLIN EVN Programme) is a commensal survey mode for the e-MERLIN + EVN, where single-target PI-led observations are re-correlated at the position of all sources within 12 arcmin. The phase centres are selected using an e-MERLIN only wide-field image generated during the initial correlation (with additional correlations from LoTSS and VLASS). This program has the potential to observe up to ~9000 radio sources per year, yielding an expected 1900 VLBI detections without any additional observing time. Here, we present preliminary results and methods from a pilot program, using a PI-led single target observation where we obtained 257 additional phase centres (127 in the calibrator field + 130 in the target field). From this study, we have investigated imaging methods for the multiple angular-scales of e-MERLIN + EVN, have tested robust pipelines to accurately detect sources and carried out an investigation into the correlation and data processing requirements of a new wide-field observing mode for the EVN (commensal multiple phase centre correlation) as part of SWEEPs. This understanding is important for its implementation as part of a future SKA-VLBI, a mode that will require significantly more phase centres (1000s) due to SKA's increased sensitivity.
Celebrating 40 years of astrometric and geodetic VLBI data – a solid foundation for celestial and terrestrial reference frames
Creators: name: Krásná, Hana
Publisher: name: Zenodo
Year: 2023

description: Very Long Baseline Interferometry (VLBI) is a measurement technique at radio wavelengths, which is used - among others - for astrometric and geodetic purposes providing a unique source of data for the creation of global celestial and terrestrial reference frames. Furthermore, it is the only measurement technique that provides the full set of Earth orientation parameters, which describe the connection between the two reference frames.
 In this talk, I introduce the latest VLBI celestial and terrestrial reference frames VIE2022 computed at TU Wien which include VLBI data until December 2022. They can be seen as an extension of the current International Celestial and Terrestrial Reference Frames, the ICRF3-sx and ITRF2020, which incorporate the VLBI observations at the standard S/X band frequencies (2.3/8.4 GHz) until March 2018 (ICRF3-sx) and December 2020 (ITRF2020). In the framework of the K band collaboration, a celestial reference frame at the frequency 24 GHz is also estimated at TU Wien. Over 99% of the K band single frequency data are produced by the Very Long Baseline Array (VLBA), which induces challenges in the data analysis connected to the geometry of the telescopes placed in the territory of United States. Furthermore, the latest terrestrial reference frames incorporate data from the novel VLBI Global Observing System (VGOS) which is based on the broadband delay using several frequency bands in the range from 2.5 to 14 GHz. The first test sessions were run in December 2017 and the regular observations started in January 2019. The challenges adherent to the position estimation of the newly built VGOS telescopes are addressed.
HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function
Creators: name: Barker, Edward
name: Planelles, Vicente
name: Karn, Jonathan
name: Garrido, Carolina
name: Margolis, David M.
name: Soriano-Sarabia, Natalia
name: Checkley, Mary Ann
name: Spivak, Adam M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In an effort to clear persistent HIV infection and achieve a durable therapy-free remission of HIV disease, extensive pre-clinical studies and early pilot clinical trials are underway to develop and test agents that can reverse latent HIV infection and present viral antigen to the immune system for clearance. It is, therefore, critical to understand the impact of latency-reversing agents (LRAs) on the function of immune effectors needed to clear infected cells. We assessed the impact of LRAs on the function of natural killer (NK) cells, the main effector cells of the innate immune system. We studied the effects of three histone deacetylase inhibitors [SAHA or vorinostat (VOR), romidepsin, and panobinostat (PNB)] and two protein kinase C agonists [prostratin (PROST) and ingenol] on the antiviral activity, cytotoxicity, cytokine secretion, phenotype, and viability of primary NK cells. We found that ex vivo exposure to VOR had minimal impact on all parameters assessed, while PNB caused a decrease in NK cell viability, antiviral activity, and cytotoxicity. PROST caused non-specific NK cell activation and, interestingly, improved antiviral activity. Overall, we found that LRAs can alter the function and fate of NK cells, and these effects must be carefully considered as strategies are developed to clear persistent HIV infection.
E11 and exceptional field theory
Creators: name: Tumanov, Alexander G.
name: West, Peter
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We demonstrate that exceptional field theory is a truncation of the non-linear realisation of the semi-direct product of E11 and its first fundamental as proposed in 2003. Evaluating the simple equations of the E11 approach, and using the commutators of the E11 algebra, we find the equations of exceptional field theory after making a radical truncation. This procedure does not respect any of the higher level E11 symmetries and so these are lost. We suggest that the need for the section condition in exceptional field theory could be a consequence of the truncation.
description: 39 pages
Brunia angulata Class. - Bockh. & E. G. H. Oliv.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Brunia
Brunia angulata

description: Brunia angulata (E. Mey. ex Sond.) Class.-Bockh. & E.G.H. Oliv., comb. nov. ≡ Berardia angulata E. Mey. ex Sond. in Harvey & Sonder, Fl. Cap. 2: 320. 1862 ≡ Raspalia angulata (E. Mey. ex Sond.) Nied. in Engler & Prantl, Nat. Pflanzenfam. 2a: 135. 1891; Pillansin J. S. African Bot. 13: 150. 1947 – Lectotype (designated here by Oliver): Drège 6868 (S-G-8321 [ex herb. Sonder], lecto; K-75868 [herb. Hooker]!, S-08-7155, TCD-2726, isolecto).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1150, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
title: Iowa Byington Reed diary 04, January 1, 1876-November 15, 1877
Creators: name: Reed, Iowa Byington
Publisher: name: University of Iowa. Libraries
Year: 2012
Subjects: subject: FOS: History and archaeology
valueUri: http://www.oecd.org/science/inno/38235147.pdf
subject: FOS: History and archaeology
subject: Domestic life
valueUri: http://id.loc.gov/vocabulary/graphicMaterials/tgm003216

description: Iowa Byington Reed's diaries contain daily entries covering her life from age twenty to just a few weeks before her death at age eighty-four (1872-1936).
Electric-field control of interfering transport pathways in a single-molecule anthraquinone transistor
Creators: name: Koole, M.
name: Thijssen, J. M.
name: Valkenier, H.
name: Hummelen, J. C.
name: van der Zant, H. S. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: It is understood that molecular conjugation plays an important role in charge transport through single-molecule junctions. Here, we investigate electron transport through an anthraquinone based single-molecule three-terminal device. With the use of an electric-field induced by a gate electrode, the molecule is reduced resulting into a ten-fold increase in the off-resonant differential conductance. Theoretical calculations link the change in differential conductance to a reduction-induced change in conjugation, thereby lifting destructive interference of transport pathways.
description: Nano Letters (2015)
title: Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment
title: effects of insulin treatment
titleType: AlternativeTitle
Creators: name: Iloun, Parisa
name: Abbasnejad, Zahra
name: Janahmadi, Mahyar
name: Ahmadiani, Abolhassan
name: Ghasemi, Rasoul
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Insulin
subject: Alzheimer disease
subject: insulin receptor substrate-1
subject: insulin resistance
subject: neuro-inflammation
subject: MAPK
subject: 610

description: Despite the consensus that neuro-inflammation and insulin resistance (IR) are two hallmarks of Alzheimer disease (AD), the molecular mechanisms responsible for the development of IR remain uncharacterized. MAPKs are signaling molecules that are implicated in the pathology of AD and have a role in IR development. Given that inflammatory mediators are shown to interfere with insulin signaling pathway in different cell types, the present work aimed to investigate whether neuro-inflammation induced memory loss is associated with hippocampal IR and whether insulin treatment protects against this IR. Subsequently, possible roles of MAPKs in this situation were investigated. Male Wistar rats were cannulated, and LPS (15 μg, day 0), insulin (3 mU) or saline (vehicle) were administered intra-cerebroventricularly (ICV) (days 1-6). Spatial memory performance was assessed during days 7-10 by Morris Water Maze test. Consequently, analysis of the amount of hippocampal phosphorylated forms of P38, JNK, ERK, IRS1 (ser307) and Akt (ser473) were done by Western blot. The outcomes indicated that while LPS induced memory loss and hippocampal IR (shown by elevated IRS1 and decreased Akt phosphorylation),insulin treatment nullified these effects. Molecular results also showed that LPS mediated IR and memory loss are associated with P38 but not JNK and ERK activation; this P38 activation was reversed by insulin treatment. These observations implied that one of the ways by which neuro-inflammation participates in AD is via induction of IR. It seems that this IR is mainly mediated by P38. Therefore, P38 could be considered as a molecular target for preventing IR development.
description: EXCLI Journal;Vol. 17 2018
How Mouse Macrophages Sense What Is Going On
Creators: name: Ting, Jenny P.
name: Croft, Michael
name: Ley, Klaus
name: Pramod, Akula Bala
name: Ravichandran, Kodi S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Macrophages are central to both innate and adaptive immunity. With few exceptions, macrophages are the first cells that sense trouble and respond to disturbances in almost all tissues and organs. They sense their environment, inhibit or kill pathogens, take up apoptotic and necrotic cells, heal tissue damage, and present antigens to T cells. Although the origins (yolk sac versus monocyte-derived) and phenotypes (functions, gene expression profiles, surface markers) of macrophages vary between tissues, they have many receptors in common that are specific to one or a few molecular species. Here, we review the expression and function of almost 200 key macrophage receptors that help the macrophages sense what is going on, including pathogen-derived molecules, the state of the surrounding tissue cells, apoptotic and necrotic cell death, antibodies and immune complexes, altered self molecules, extracellular matrix components, and cytokines, including chemokines.
Confirmation of the OGLE-2005-BLG-169 planet signature and characteristics with lens-source proper motion detection
Creators: name: Batista, V.
name: Beaulieu, J. -P.
name: Bennett, D. P.
name: Gould, A.
name: Marquette, J. -B.
name: Fukui, A.
name: Bhattacharya, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present Keck NIRC2 high angular resolution adaptive optics observations of the microlensing event OGLE-2005-BLG-169, taken 8.21 years after the discovery of this planetary system. For the first time for a microlensing planetary event, the source and the lens are completely resolved, providing a precise measurement of their heliocentric relative proper motion, $μ_{\rm{rel},\rm{helio}}=7.44 \pm 0.17$ mas yr$^{-1}$. This confirms and refines the initial model presented in the discovery paper and rules out a range of solutions that were allowed by the microlensing light curve. This is also the first time that parameters derived from a microlensing planetary signal are confirmed, both with Keck measurements, presented in this paper, and independent measurements obtained with the Hubble Space Telescope in I, V and B bands, presented in a companion paper. Hence, this new measurement of $μ_{\rm{rel},\rm{helio}}$, as well as the measured brightness of the lens in H band, enabled the mass and distance of the system to be updated: a Uranus-mass planet ($m_\rm{p}=13.2\pm 1.3 M_\oplus$) orbiting a K5-type main sequence star ($M_*=0.65\pm 0.05 M_\odot$) separated by $a_\perp=3.4\pm 0.3$ AU, at the distance $D_\rm{L}=4.0\pm 0.4$ kpc from us.
description: 9 pages, 5 figures
Brunia palustris Class. - Bockh. & E. G. H. Oliv.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Brunia
Brunia palustris

description: Brunia palustris (Schltr. ex Dümmer) Class.-Bockh. & E.G.H. Oliv., comb. nov. ≡ Pseudobaeckea palustris Schltr. ex Dümmer in J. Bot. 50, suppl. 2: 26. 1912 ≡ Raspalia palustris (Schtr. ex Dümmer) PillansinJ. S. African Bot. 13: 156. 1947 – Lectotype (designated here by Oliver): Schlechter 10055 (K-75862!, lecto; BOL-122407, HBG- 503128, WAG-335, S-08-73360, isolecto). Placement of thisspecies in Brunia subg. Raspalia isbased on morphological data as anther morphology, 5- to 10-colporate pollen grains, stamens included, petal morphology, appressed to partly imbricate leaves, and moderate inflorescence size; the species was not included in the DNA analysis.
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1150, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Controlling superconducting spin flow with spin-flip immunity using a single homogeneous ferromagnet
Creators: name: Jacobsen, Sol
name: Kulagina, Iryna
name: Linder, Jacob
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin transport via electrons is typically plagued by Joule heating and short decay lengths due to spin-flip scattering. It is known that dissipationless spin currents can arise when using conventional superconducting contacts, yet this has only been experimentally demonstrated when using intricate magnetically inhomogeneous multilayers, or in extreme cases such as half-metals with interfacial magnetic disorder. Moreover, it is unknown how such spin supercurrents decay in the presence of spin-flip scattering. Here, we present a method for generating a spin supercurrent by using only a single homogeneous magnetic element. Remarkably, the spin supercurrent generated in this way does not decay spatially, in stark contrast to normal spin currents that remain polarized only up to the spin relaxation length. We also expose the existence of a superconductivity-mediated torque even without magnetic inhomogeneities, showing that the different components of the spin supercurrent polarization respond fundamentally differently to a change in the superconducting phase difference. This establishes a mechanism for tuning dissipationless spin and charge flow separately, and confirms the advantage that superconductors can offer in spintronics.
description: 10 pages, 4 figures. Accepted for publication in Nature Scientific Reports
A 20+ year overview of VLBI observations of the peculiar radio source 3C 84
Creators: name: Paraschos, Georgios Filippos
Publisher: name: Zenodo
Year: 2023

description: The super-massive black holes (SMBH) located at the centres of AGN often launch highly relativistic jets. The main jet launching scenarios are either due to magnetic field lines anchored to the accretion disk (Blandford & Payne 1982) or directly connected to the black hole’s (BH) ergosphere (Blandford & Znajek 1977), and are an ongoing, hot topic of active research.
 Very long baseline interferometry (VLBI), and specifically at millimetre wavelengths, offers an unparalleled view into the physical processes in action, in the close vicinity of BHs. Owing to its proximity and only moderate Doppler-boosting, the nearby radio-galaxy 3C 84 (NGC 1275) is a very suitable target for VLBI observations at the highest frequencies and spatial resolutions. Utilising archival and our own millimetre-VLBI observations of 3C 84 obtained over the past 20+ years, we can trace the VLBI jet of 3C 84 down to scales of ∼100 Schwarzschild radii, facilitating the study of jet formation and acceleration. Our observations reveal a limb brightened, double-rail structure reaching deep into the core region. As part of this analysis we also associate jet component ejection events with the multi-wavelength variability light-curves at radio frequencies and gamma-rays. Furthermore, by cross-correlating these light-curves, which span a time frame of 40+ years, we determine time-lags and draw conclusions regarding the location of the high energy emission at the jet base. Finally, we constrain the magnetic field strength and structure. In this talk I will give an overview of more than four decades of VLBI observations of 3C 84 and then present new results from recent global VLBI imaging campaigns.
B and T Cell Phenotypic Profiles of African HIV-Infected and HIV-Exposed Uninfected Infants: Associations with Antibody Responses to the Pentavalent Rotavirus Vaccine
Creators: name: Gaseitsiwe, Simani
name: Canniff, Jennifer
name: Asmelash, Aida
name: Sato, Paul
name: Chi, Benjamin H.
name: Persaud, Deborah
name: Moraka, Natasha O.
name: Lockman, Shahin
name: Bosch, Ronald
name: Ogwu, Anthony
name: Smith, Christiana Elizabeth
name: Moyo, Sikhulile
name: Bwakura-Dangarambezi, Mutsa
name: Lindsey, Jane
name: Levin, Myron J.
name: Weinberg, Adriana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: We examined associations between B and T cell phenotypic profiles and antibody responses to the pentavalent rotavirus vaccine (RV5) in perinatally HIV-infected (PHIV) infants on antiretroviral therapy and in HIV-exposed uninfected (PHEU) infants enrolled in International Maternal Pediatric Adolescent AIDS Clinical Trials P1072 study ({"type":"clinical-trial","attrs":{"text":"NCT00880698","term_id":"NCT00880698"}}NCT00880698). Of 17 B and T cell subsets analyzed, PHIV and PHEU differed only in the number of CD4+ T cells and frequency of naive B cells, which were higher in PHEU than in PHIV. In contrast, the B and T cell phenotypic profiles of PHIV and PHEU markedly differed from those of geographically matched contemporary HIV-unexposed infants. The frequency of regulatory T and B cells (Treg, Breg) of PHIV and PHEU displayed two patterns of associations: FOXP3+ CD25+ Treg positively correlated with CD4+ T cell numbers; while TGFβ+ Treg and IL10+ Treg and Breg positively correlated with the frequencies of inflammatory and activated T cells. Moreover, the frequencies of activated and inflammatory T cells of PHIV and PHEU positively correlated with the frequency of immature B cells. Correlations were not affected by HIV status and persisted over time. PHIV and PHEU antibody responses to RV5 positively correlated with CD4+ T cell counts and negatively with the proportion of immature B cells, similarly to what has been previously described in chronic HIV infection. Unique to PHIV and PHEU, anti-RV5 antibodies positively correlated with CD4+/CD8+FOXP3+CD25+% and negatively with CD4+IL10+% Tregs. In conclusion, PHEU shared with PHIV abnormal B and T cell phenotypic profiles. PHIV and PHEU antibody responses to RV5 were modulated by typical HIV-associated immune response modifiers except for the association between CD4+/CD8+FOXP3+CD25+Treg and increased antibody production.
Proximity-induced Josephson $π$-Junctions in Topological Insulators
Creators: name: Schrade, Constantin
name: Zyuzin, A. A.
name: Klinovaja, Jelena
name: Loss, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study two microscopic models of topological insulators in contact with an $s$-wave superconductor. In the first model the superconductor and the topological insulator are tunnel coupled via a layer of scalar and of randomly oriented spin impurities. Here, we require that spin-flip tunneling dominates over spin-conserving one. In the second model the tunnel coupling is realized by an array of single-level quantum dots with randomly oriented spins. It is shown that the tunnel region forms a $π$-junction where the effective order parameter changes sign. Interestingly, due to the random spin orientation the effective descriptions of both models exhibit time-reversal symmetry. We then discuss how the proposed $π$-junctions support topological superconductivity without magnetic fields and can be used to generate and manipulate Kramers pairs of Majorana fermions by gates.
Gas morphology and kinematics of NGC 4261: Probing the AGN fueling with VLBI
Creators: name: Sawada-Satoh, Satoko
Publisher: name: Zenodo
Year: 2023

description: It is now widely accepted that active galactic nucleus (AGN) activity is powered by mass accretion onto a central supermassive black hole (SMBH). How the ambient environment of AGN drives mass accretion is one of the most important questions regarding the AGN fueling process. To date, VLBI has revealed the parsec- and/or sub-parsec-scale morphology and kinematics in the immediate vicinity of the SMBH. Moreover, millimeter and submillimeter interferometers such as SMA, ALMA and NOEMA can provide complementary information about the circumnuclear environment on sub-kiloparsec scales. In this talk, we present the recent results from our NOEMA and VLBI observations toward a nearby radio-loud AGN NGC 4261. We detected HCN and HCO+ J=1-0 emissions representing a rotating circumnuclear disk with an outer radius of 100 pc. In addition, we imaged 22 GHz water maser emission, at the positions where the free-free absorption opacity was high on the receding jet. To explain all the observed characteristics, we propose a scenario of multiphase gas disk with ionized and molecular gases, as a reservoir of fuel for its SMBH.
Brunia squalida Sond.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Brunia
Brunia squalida

description: Brunia squalida E. Mey. ex Sond. in Harvey & Sonder, Fl. Cap. 2: 315. 1862 – Lectotype (designated here by Oliver): Dutoitskloof, 2[000]– 3000 ft, Oct–Jan, Drège s.n. (S-G- 8317 [ex herb. Sond.], lecto; MEL-27692 [ex herb. Sond.], isolecto). = Passerinaglobosa Lam., Encycl.1(2): 431.1792, syn. nov., non Bruniaglobosa Thunb., Brunia:4. 1804 (= Bruniafragarioides Willd.) ≡ Raspalia globosa (Lam.) Pillansin J. S. African Bot. 13: 159, 1947 – Type: sine loc., sinecoll. 701 (P, herb. Lamarck, holo; BOL-122259 fragm. ex P!, iso).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1151, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy
Creators: name: Zhang, Kaiyu
name: Wang, Feng
name: Tu, Zhengkun
name: Li, Haijun
name: Zhai, Naicui
name: Bao, Wanguo
name: Wang, Yang
name: Su, Lishan
name: Jin, Xia
name: Lou, Lixin
name: Song, Hongxiao
name: Li, Yuxiang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Brucellosis is caused by infection with Brucella species and exhibits diverse clinical manifestations in infected humans. Monocytes and macrophages are not only the first line of defense against Brucella infection but also a main reservoir for Brucella. In the present study, we examined the effects of Brucella infection on human peripheral monocytes and monocyte-derived polarized macrophages. We showed that Brucella infection led to an increase in the proportion of CD14++CD16− monocytes and the expression of the autophagy-related protein LC3B, and the effects of Brucella-induced monocytes are inhibited after 6 weeks of antibiotic treatment. Additionally, the production of IL-1β, IL-6, IL-10, and TNF-α from monocytes in patients with brucellosis was suppressed through the LC3-dependent autophagy pathway during Brucella infection. Moreover, Brucella infection inhibited macrophage polarization. Consistently, the addition of 3-MA, an inhibitor of LC3-related autophagy, partially restored macrophage polarization. Intriguingly, we also found that the upregulation of LC3B expression by rapamycin and heat-killed Brucella in vitro inhibits M2 macrophage polarization, which can be reversed partially by 3-MA. Taken together, these findings reveal that Brucella dysregulates monocyte and macrophage polarization through LC3-dependent autophagy. Thus, targeting this pathway may lead to the development of new therapeutics against Brucellosis.
Brunia callunoides Class. - Bockh. & E. G. H. Oliv.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Brunia
Brunia callunoides

description: Brunia callunoides (Oliv.) Class.-Bockh. & E.G.H. Oliv., comb. nov. ≡ Berzelia callunoides Oliv. in J. Linn. Soc., Bot. 9: 333. 1867 ≡ Mniothamnea callunoides (Oliv.) Nied. in Engler & Prantl, Nat. Pflanzenfam. 2a: 136. 1891; Pillans in J. S. African Bot. 13: 168. 1947 – Lectotype (designated here by Hall): Burchell 7382 (K-75843!).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1151, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases
Creators: name: Chattopadhyay, Samit
name: Gautam, Dipendra
name: Mirlekar, Bhalchandra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: T cell differentiation from naïve T cells to specialized effector subsets of mature cells is determined by the iterative action of transcription factors. At each stage of specific T cell lineage differentiation, transcription factor interacts not only with nuclear proteins such as histone and histone modifiers but also with other factors that are bound to the chromatin and play a critical role in gene expression. In this review, we focus on one of such nuclear protein known as tumor suppressor and scaffold matrix attachment region-binding protein 1 (SMAR1) in CD4+ T cell differentiation. SMAR1 facilitates Th1 differentiation by negatively regulating T-bet expression via recruiting HDAC1–SMRT complex to its gene promoter. In contrast, regulatory T (Treg) cell functions are dependent on inhibition of Th17-specific genes mainly IL-17 and STAT3 by SMAR1. Here, we discussed a critical role of chromatin remodeling protein SMAR1 in maintaining a fine-tuned balance between effector CD4+ T cells and Treg cells by influencing the transcription factors during allergic and autoimmune inflammatory diseases.
Brunia trigyna Class. - Bockh. & E. G. H. Oliv.
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Brunia
Brunia trigyna

description: Brunia trigyna (Schltr.) Class.-Bockh. & E.G.H. Oliv., comb. nov. ≡ Berardia trigyna Schltr. in J. Bot. 36: 315. 1898 ≡ Raspalia trigyna (Schltr.) Dümmer in J. Bot. 50, suppl. 2: 21. 1912; Pillansin J. S. African Bot. 13: 152. 1947 – Lectotype (designated here by Hall): Wood 3029 (B- 100154425, lecto; K!, NH, isolecto).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1151, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
title: Iowa Byington Reed diary 05, January 1, 1878- May 11, 1879
Creators: name: Reed, Iowa Byington
Publisher: name: University of Iowa. Libraries
Year: 2012
Subjects: subject: FOS: History and archaeology
valueUri: http://www.oecd.org/science/inno/38235147.pdf
subject: FOS: History and archaeology
subject: Domestic life
valueUri: http://id.loc.gov/vocabulary/graphicMaterials/tgm003216

description: Iowa Byington Reed's diaries contain daily entries covering her life from age twenty to just a few weeks before her death at age eighty-four (1872-1936).
Cold gas in the heart of 3C84
Creators: name: Morganti, Raffaella
Publisher: name: Zenodo
Year: 2023

description: One way to trace and study cold gas in the central regions of radio galaxies is by observing HI in absorption at the high resolution offered by VLBI. In this way, we can identify the location and properties of the gas. The presence of rotating structures (circumnuclear discs and tori) and of gas with disturbed or highly turbulent kinematics, are all key elements for understanding the evolution of both the AGN and the host galaxy. Here we focus on the case of 3C84, one of the most famous radio galaxies, located in the central galaxy (NGC 1275) of the iconic gas-rich, cool-core Perseus cluster. Earlier, two HI absorption systems have been found in this object: one extremely narrow and highly redshifted, likely associated with a galaxy interacting with NGC1275, and one as broad as FWZI~800 km/s, centred around the systemic velocity of NGC1275. The latter has been the focus of our study. We have traced this HI component on multiple scales, from kpc (using the WSRT and VLA) down to pc scales using the VLBA. While the deep and broad absorption is clearly observed on the few hundred pc scales probed by the VLA - the surprising result obtained with the VLBA indicates that the HI in this radio galaxy is not located against the core or the jet of 3C84, but instead in a larger, disk-like structure of at least 100 pc, perpendicular to the jet. Indications for the presence of such a structure in radio continuum (i.e. the background that allows us to see the HI in absorption) was already found years ago in low-frequency VLBA observations while the presence of a cold molecular circumnuclear disc of similar size is confirmed by ALMA. The similarity of the velocities covered by the HI and the molecular gas indicate that neutral hydrogen should be present down to distances of 60 pc from the SMBH. The combination of the HI observed in absorption and the molecular gas (observed in emission) tells us about the structure of the circumnuclear disc and are essential information for obtaining a complete view of the complex nuclear region of AGN.
 We do not see signatures of the cold HI gas being affected by the interaction with the radio jet and we discuss the likely impact of the jet on the evolution of the radio source.
 If time allows, these results will be compared with what found from HI VLBI observations for other radio galaxies.
Mutually Unbiased Product Bases for Multiple Qudits
Creators: name: McNulty, Daniel
name: Pammer, Bogdan
name: Weigert, Stefan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate the interplay between mutual unbiasedness and product bases for multiple qudits of possibly different dimensions. A product state of such a system is shown to be mutually unbiased to a product basis only if each of its factors is mutually unbiased to all the states which occur in the corresponding factors of the product basis. This result implies both a tight limit on the number of mutually unbiased product bases which the system can support and a complete classification of mutually unbiased product bases for multiple qubits or qutrits. In addition, only maximally entangled states can be mutually unbiased to a maximal set of mutually unbiased product bases.
description: 15 pages, identical to published version
The 40-yr History of 3C84 and Future Prospects with VLBI and ALMA
Creators: name: Nagai, Hiroshi
Publisher: name: Zenodo
Year: 2023

description: 3C 84 is the bright, nearby radio source that is associated with a giant elliptical galaxy NGC 1275 (z=0.0176). Thanks to its proximity and brightness, 3C 84 has been studied using VLBI extensively in the context of jet formation, mechanism of high energy emission, jet interaction with circumnuclear gas, and so on. In this talk, I will look back the 40-yr history of 3C 84 study with VLBI. Then, I will present our recent ALMA+VLBI results on the study of inflow from galactic scale to parsec scale as well as AGN outflow in connection with the jet activity.
Brunia monogyna
Creators: name: Claßen-Bockhoff, Regine
name: Oliver, Edward G. H.
name: Hall, Anthony V.
name: Quint, Marcus
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Bruniales
Bruniaceae
Brunia
Brunia monogyna

description: Bruniamonogyna (Vahl) Class.-Bockh. & E.G.H. Oliv., comb. nov. ≡ Ptyxostoma monogyna Vahl in Danske Nat. Selsk. Skriv. 4: 96. 1810 ≡ Lonchostoma monogynum (Vahl) Pillansin J. S. African Bot. 13: 134. 1947 – Type: Cap. B. spei, sine coll. exherbario Royenii (C-10000422, ex herb. Royenii, holo).
description: Published as part of Claßen-Bockhoff, Regine, Oliver, Edward G. H., Hall, Anthony V. & Quint, Marcus, 2019, A new classification of the South African endemic family Bruniaceae based on molecular and morphological data, pp. 1138-1155 in TAXON 60 (4) on page 1152, DOI: 10.1002/tax.604016, http://zenodo.org/record/7590433
Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas
Creators: name: Sidney, John
name: Diehl, Sean A.
name: Satchidanandam, Vijaya
name: Grifoni, Alba
name: Costa, Priscilla R.
name: Sette, Alessandro
name: Macary, Paul A.
name: Nchinda, Godwin
name: de Silva, Aravinda M.
name: Desai, Anita
name: Turtle, Lance
name: Cerpas, Cristhiam
name: Rivino, Laura
name: Harris, Eva
name: Ravi, Vasanthapram
name: Peters, Bjoern
name: Phillips, Elizabeth
name: Solomon, Tom
name: de Silva, Aruna D.
name: Tatullo, Filippo
name: Nkenfou, Celine
name: Durbin, Anna P.
name: Coloma, Josefina
name: Lim, Mei Qiu
name: O'Rourke, Patrick H.
name: Weiskopf, Daniela
name: Collins, Matthew H.
name: Kallas, Esper G.
name: Lopez, Benjamin
name: Angelo, Michael A.
name: Maestri, Alvino
name: Balmaseda, Angel
name: Silveira, Cassia G.T.
name: Mallal, Simon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Dengue is a major public health problem worldwide. Assessment of adaptive immunity is important to understanding immunopathology and to define correlates of protection against dengue virus (DENV). To enable global assessment of CD4+ T cell responses, we mapped HLA-DRB1-restricted DENV-specific CD4+ T cell epitopes in individuals previously exposed to DENV in the general population of the dengue-endemic region of Managua, Nicaragua.
Scalar - Tensor gravity with scalar -matter direct coupling and its cosmological probe
Creators: name: Kim, Jik Su
name: Kim, Chol Jun
name: Hwang, Sin Chol
name: Ko, Yong Hae
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: SNIA and CMB datasets have shown both of evolving Newton's "constant" and a signature of the coupling of scalar field to matter. These observations motivate the consideration of the scalar-matter coupling in Jordan frame in the framework of scalar-tensor gravity. So far, majority of the works on the coupling of scalar matter has performed in Einstein frame in the framework of minimally coupled scalar fields. In this work, we generalize the original scalar-tensor theories of gravity introducing a direct coupling of scalar to matter in the Jordan frame. The combined consideration of both evolving Newton's constant and scalar-matter coupling using the recent observation datasets, shows features different from the previous works. The analysis shows a vivid signature of the scalar-matter coupling. The variation rate of the Newton's constant is obtained rather greater than that determined in the previous works.
description: 13 pages, 2 figures, 2 tables
Accelerating coordination in temporal networks by engineering the link order
Creators: name: Masuda, Naoki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Social dynamics on a network may be accelerated or decelerated depending on which pairs of individuals in the network communicate early and which pairs do later. The order with which the links in a given network are sequentially used, which we call the link order, may be a strong determinant of dynamical behaviour on networks, potentially adding a new dimension to effects of temporal networks relative to static networks. Here we study the effect of the link order on linear coordination (i.e., synchronisation) dynamics. We show that the coordination speed considerably depends on specific orders of links. In addition, applying each single link for a long time to ensure strong pairwise coordination before moving to a next pair of individuals does not often enhance coordination of the entire network. We also implement a simple greedy algorithm to optimise the link order in favour of fast coordination.
description: 5 figures
P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis
Creators: name: Blackburn, Michael R.
name: Müller, Tobias
name: Boeynaems, Jean-Marie
name: Zissel, Gernot
name: Di Virgilio, Francesco
name: Robaye, Bernard
name: Ayata, Cemil Korcan
name: Fay, Susanne
name: Karmouty-Quintana, Harry
name: Lazarowski, Eduardo R.
name: Vieira, Rodolfo Paula
name: Idzko, Marco
name: Goldmann, Torsten
name: Ferrari, Davide
name: Lungarella, Giuseppe
name: Cicko, Sanja
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor subtypes P2Y2 and P2X7 in fibrotic lung disease has been demonstrated recently. In this study, we investigated the role of P2Y6 receptors in the pathogenesis of IPF in humans and in the animal model of bleomycin-induced lung injury. P2Y6R expression was upregulated in lung structural cells but not in bronchoalveolar lavage (BAL) cells derived from IPF patients as well as in animals following bleomycin administration. Furthermore, BAL fluid levels of the P2Y6R agonist uridine-5′-diphosphate were elevated in animals with bleomycin-induced pulmonary fibrosis. Inflammation and fibrosis following bleomycin administration were reduced in P2Y6R-deficient compared to wild-type animals confirming the pathophysiological relevance of P2Y6R subtypes for fibrotic lung diseases. Experiments with bone marrow chimeras revealed the importance of P2Y6R expression on lung structural cells for pulmonary inflammation and fibrosis. Similar effects were obtained when animals were treated with the P2Y6R antagonist MRS2578. In vitro studies demonstrated that proliferation and secretion of the pro-inflammatory/pro-fibrotic cytokine IL-6 by lung fibroblasts are P2Y6R-mediated processes. In summary, our results clearly demonstrate the involvement of P2Y6R subtypes in the pathogenesis of pulmonary fibrosis. Thus, blocking pulmonary P2Y6 receptors might be a new target for the treatment of IPF.