cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BEFRIENding for Depression, Anxiety and Social support in older adults living in Australian residential aged care facilities (BEFRIENDAS): randomised controlled trial protocol
Creators: name: Doyle, C
name: Bhar, S
name: Bryant, C
name: Dow, B
name: Dunt, D
name: Mnatzaganian, George
name: O’Connor, D
name: Ratcliffe, J
name: You, E
name: Bagnall, AM
name: Major, G
name: Harper, Robin
name: Fearn, M
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences

description: Background: This protocol describes an ongoing study of the impact of befriending on depression, anxiety and loneliness in older people living in residential aged care facilities in Australia. While systematic reviews of befriending have indicated positive benefits of befriending for people in a range of ages and settings, there have been no randomised controlled trials (RCTs) of befriending for older people living in residential aged care with depression and no studies of the cost effectiveness of befriending in residential aged care facilities (RACFs) in Australia. Methods and analysis: We are conducting a single blind pragmatic RCT comparing two groups of older people living in RACFs, one receiving an intervention consisting of weekly befriending for 4 months from a trained volunteer and the other receiving treatment as usual. Participants undergo eligibility screening for depression (GDS-15 ≥ 4) and cognitive impairment (GPCog ≥ 4) and assessments at three measurement time points: baseline prior to randomisation, 2 months post-baseline and 4 months post-baseline. The primary outcome measure is depression, and secondary outcome measures are anxiety, loneliness, social isolation and quality of life. The economic evaluation will take the form of a cost-utility analysis based on the outcome of quality of life. The primary and secondary outcomes will be analysed using negative binomial and logistic regressions utilizing the Generalised Estimating Equations approach. Discussion: To our knowledge, this is the first RCT evaluating the effectiveness of befriending on older people with depression living in residential aged care. It is expected that the befriending intervention will reduce the severity of depression symptoms experienced by older people living in residential aged care. If the intervention proves effective it may be incorporated into volunteer training programs and adopted as a way of supporting older people’s mental health. Trial registration: Trial registered with the Australian and New Zealand Clinical Trial Registry (ANZCTR) Number: ACTRN12619000676112, registered 06/05/2019 – retrospectively registered.
Bi-convex model based reconstruction methods for magnetic resonance elastography
Creators: name: Mohammed, Shahed Khan
Publisher: name: University of British Columbia
Year: 2023

description: Magnetic resonance elastography (MRE) is a biomechanical imaging tool that reconstructs the tissue elasticity map by capturing tissue displacement with magnetic resonance imaging (MRI). MRE has the unique advantage of capturing all three directional displacement components with a moveable and deep field of view. In addition, MRE offers the functionality to incorporate other MRI contrast seamlessly to extend MRE for advanced biomechanical models. However, MRE is limited by its long scanning time, low signal-to-noise ratio, and low resolution. This thesis focuses on iterative model-based reconstruction techniques with structured sparsity for faster MRE acquisition and robust elastogram reconstruction. A new optimization technique for elastogram reconstruction is proposed using the bi-convexity of the elastodynamic model and the alternating direction method of multipliers (ADMM). The proposed optimization technique allows easy integration of structured sparsity and is robust to noise and initialization. Four elastography reconstruction methods were implemented in this thesis with different models and regularization prior: (a) scalar 2D shear wave model (2D-ERBA), (b) scalar 3D shear wave model (3D-ERBA), (c) vector 3D elastodynamic wave model (ERSA), and (d) multifrequency vector 3D elastodynamic wave model (MERSA). The former two elastography reconstruction methods used a sparsity prior to the shear modulus, while the latter used sparsity prior on both shear modulus and displacement. These methods were extensively validated for in silico, in vitro, and in vivo datasets and compared with state-of-the-art methods. Experiments showed that MERSA provides higher robustness to noise, higher robustness to wavelength-to-voxel ratio, and higher accuracy for both elasticity and viscosity. A comparison study of diagnostic performance in detecting liver disease of scalar 2D shear wave model, scalar 3D shear wave model, and vector 3D elastodynamic wave model with MERSA implementation concludes the reconstruction part of this thesis. A bi-convex optimization-based displacement regularized compressed sensing (DRCS) method is proposed for fast MRE acquisition. The proposed method uses separate sparsity prior on the magnitude, phase and displacement to recover the MR signal from a highly undersampled k-space. We compare the performance of DRCS with other compressed sensing methods for highly undersampled data from in silico, in vitro and in vivo datasets.
BEFRIENding for Depression, Anxiety and Social support in older adults living in Australian residential aged care facilities (BEFRIENDAS): randomised controlled trial protocol
Creators: name: Doyle, C
name: Bhar, S
name: Bryant, C
name: Dow, B
name: Dunt, D
name: Mnatzaganian, George
name: O’Connor, D
name: Ratcliffe, J
name: You, E
name: Bagnall, AM
name: Major, G
name: Harper, R
name: Fearn, M
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: This protocol describes an ongoing study of the impact of befriending on depression, anxiety and loneliness in older people living in residential aged care facilities in Australia. While systematic reviews of befriending have indicated positive benefits of befriending for people in a range of ages and settings, there have been no randomised controlled trials (RCTs) of befriending for older people living in residential aged care with depression and no studies of the cost effectiveness of befriending in residential aged care facilities (RACFs) in Australia. Methods and analysis: We are conducting a single blind pragmatic RCT comparing two groups of older people living in RACFs, one receiving an intervention consisting of weekly befriending for 4 months from a trained volunteer and the other receiving treatment as usual. Participants undergo eligibility screening for depression (GDS-15 ≥ 4) and cognitive impairment (GPCog ≥ 4) and assessments at three measurement time points: baseline prior to randomisation, 2 months post-baseline and 4 months post-baseline. The primary outcome measure is depression, and secondary outcome measures are anxiety, loneliness, social isolation and quality of life. The economic evaluation will take the form of a cost-utility analysis based on the outcome of quality of life. The primary and secondary outcomes will be analysed using negative binomial and logistic regressions utilizing the Generalised Estimating Equations approach. Discussion: To our knowledge, this is the first RCT evaluating the effectiveness of befriending on older people with depression living in residential aged care. It is expected that the befriending intervention will reduce the severity of depression symptoms experienced by older people living in residential aged care. If the intervention proves effective it may be incorporated into volunteer training programs and adopted as a way of supporting older people’s mental health. Trial registration: Trial registered with the Australian and New Zealand Clinical Trial Registry (ANZCTR) Number: ACTRN12619000676112, registered 06/05/2019 – retrospectively registered.
Presentation of the Second Big Challenge Symposium - The Big Challenge of Cosmological Understanding: Gravitation, Dark Matter and Dark Energy. Towards New Scenarios
Creators: name: Corda, Christian
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: This Symposium is devoted to the Memory of Lev Kofman, June-17-1957-November-12-2009. The accelerated expansion of the Universe, which is today observed, shows that cosmological dynamics is dominated by the so-called Dark Energy field which provides a large negative pressure. This is the standard picture, in which such new ingredient is considered as a source of the right hand side of the field equations. It should be some form of non-clustered non-zero vacuum energy which, together with the clustered Dark Matter, drives the global dynamics. This is the so-called "concordance model" (ACDM) which gives, in agreement with the Cosmic Microwave Background Radiation (CMBR), dim Lyman Limit Systems (LLS) and type la supernovae (SNeIa) data, a good framework to understand the today observed Universe. However, it presents several shortcomings as the well known "coincidence" and "cosmological constant" problems . An alternative approach is to have a better understanding of the energy concept in General Relativity and also to change the left hand side of the field equations, and check if observed cosmic dynamics can be achieved by extending general relativity. In this different context, it is not required to search candidates for Dark Energy and Dark Matter, which till now have not been found. Rather, one can only stand on the "observed" ingredients: curvature and baryon matter, to account for the observations. Considering this point of view, one can think of that gravity is not scale-invariant. The goal of this Symposium is to obtain a tapestry of the present status of theory and observations concerning Gravitation and Dark Universe.
description: To appear in the AIP Proceedings of the 8th International Conference of Numerical Analysis and Applied Mathematics, Hotel Rodos Palace, Rhodes, Greece, 1925 September 2010
Holographic bounds and Higgs inflation
Creators: name: Horvat, R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In a recently proposed scenario for primordial inflation, where the Standard Model (SM) Higgs boson plays a role of the inflation field, an effective field theory (EFT) approach is the most convenient for working out the consequences of breaking of perturbative unitarity, caused by the strong coupling of the Higgs field to the Ricci scalar. The domain of validity of the EFT approach is given by the ultraviolet (UV) cutoff, which, roughly speaking, should always exceed the Hubble parameter in the course of inflation. On the other hand, applying the trusted principles of quantum gravity to a local EFT demands that it should only be used to describe states in a region larger than their corresponding Schwarschild radius, manifesting thus a sort of UV/IR correspondence. We consider both constraints on EFT, to ascertain which models of the SM Higgs inflation are able to simultaneously comply with them. We also show that if the gravitational coupling evolves with the scale factor, the holographic constraint can be alleviated significantly with minimal set of canonical assumptions, by forcing the said coupling to be asymptotically free.
description: 9 pages, new material and references added, to appear in PLB
BCL-XL is an actionable target for treatment of malignant pleural mesothelioma
Creators: name: Arulananda, Surein
name: O'Brien, Megan
name: Evangelista, M
name: Harris, TJ
name: Steinohrt, NS
name: Jenkins, Laura
name: Walkiewicz, M
name: O’Donoghue, RJJ
name: Poh, Ashleigh
name: Thapa, B
name: Williams, David
name: Leong, T
name: Mariadason, John
name: Li, Xia
name: Cebon, Jonathan
name: Lee, Erinna
name: John, Thomas
name: Fairlie, Walter
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3211
subject: Oncology and carcinogenesis

description: © 2020, The Author(s). Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural mesothelioma (MPM) in over a decade. Standard-of-care treatment relies on Cisplatin plus Pemetrexed chemotherapy. Here, we tested a suite of BH3-mimetic drugs targeting BCL-2 pro-survival proteins of the intrinsic apoptotic pathway. We found BCL-XL is the dominant pro-survival protein in a panel of cell lines in vitro, though potent, synergistic cell killing occurred with MCL-1 co-targeting. This correlates with high-level expression of BCL-XL and MCL-1 in cell lines and a large cohort of patient tumour samples. BCL-XL inhibition combined with Cisplatin also enhanced cell killing. In vivo BCL-XL inhibition was as effective as Cisplatin, and the combination enhanced tumour growth control and survival. Genetic ablation of MCL-1 also enhanced the effects of BCL-XL inhibitors, in vivo. Combined, these data provide a compelling rationale for the clinical investigation of BH3-mimetics targeting BCL-XL in MPM.
BCL-XL is an actionable target for treatment of malignant pleural mesothelioma
Creators: name: Surein Arulananda
name: M O’Brien
name: M Evangelista
name: TJ Harris
name: NS Steinohrt
name: Jenkins, Laura
name: M Walkiewicz
name: RJJ O’Donoghue
name: Poh, Ashleigh
name: B Thapa
name: Williams, David
name: T Leong
name: Mariadason, John
name: Li, Xia
name: Cebon, Jonathan
name: Erinna Lee
name: John, Thomas
name: Fairlie, Walter
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2020, The Author(s). Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural mesothelioma (MPM) in over a decade. Standard-of-care treatment relies on Cisplatin plus Pemetrexed chemotherapy. Here, we tested a suite of BH3-mimetic drugs targeting BCL-2 pro-survival proteins of the intrinsic apoptotic pathway. We found BCL-XL is the dominant pro-survival protein in a panel of cell lines in vitro, though potent, synergistic cell killing occurred with MCL-1 co-targeting. This correlates with high-level expression of BCL-XL and MCL-1 in cell lines and a large cohort of patient tumour samples. BCL-XL inhibition combined with Cisplatin also enhanced cell killing. In vivo BCL-XL inhibition was as effective as Cisplatin, and the combination enhanced tumour growth control and survival. Genetic ablation of MCL-1 also enhanced the effects of BCL-XL inhibitors, in vivo. Combined, these data provide a compelling rationale for the clinical investigation of BH3-mimetics targeting BCL-XL in MPM.
Investigation of jet quenching and elliptic flow within a pQCD-based partonic transport model
Creators: name: Fochler, Oliver
name: Xu, Zhe
name: Greiner, Carsten
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The partonic transport model BAMPS (a Boltzmann approach to multiparton scatterings) is employed to investigate different aspects of heavy ion collisions within a common framework based on perturbative QCD. This report focuses on the joint investigation of the collective behavior of the created medium and the energy loss of high-pT gluons traversing this medium. To this end the elliptic flow and the nuclear modification factor of gluons in heavy ion collisions at 200 AGeV are simulated with BAMPS. The mechanism for the energy loss of high energy gluons within BAMPS is studied in detail. For this, purely elastic interactions are compared to radiative processes, gg -> ggg, that are implemented based on the matrix element by Gunion and Bertsch. The latter are found to be the dominant source of energy loss within the framework employed in this work.
description: To appear in the proceedings of the 26th Winter Workshop on Nuclear Dynamics (2010).
Local Space-Time Curvature Effects on Quantum Orbital Angular Momentum
Creators: name: Singh, Dinesh
name: Mobed, Nader
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper claims that local space-time curvature can non-trivially contribute to the properties of orbital angular momentum in quantum mechanics. Of key importance is the demonstration that an extended orbital angular momentum operator due to gravitation can identify the existence of orbital states with half-integer projection quantum numbers "m" along the axis of quantization, while still preserving integer-valued orbital quantum numbers "l" for a simply connected topology. The consequences of this possibility are explored in depth, noting that the half-integer "m" states vanish as required when the locally curved space-time reduces to flat space-time, fully recovering all established properties of orbital angular momentum in this limit. In particular, it is shown that a minimum orbital number of "l = 2" is necessary for the gravitational interaction to appear within this context, in perfect correspondence with the spin-2 nature of linearized general relativity.
description: 21 pages, 1 figure; references added; accepted for publication in Classical and Quantum Gravity
Quantum Communication Technology
Creators: name: Gisin, Nicolas
name: Thew, Rob
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: Quantum communication is built on a set of disruptive concepts and technologies. It is driven by fascinating physics and by promising applications. It requires a new mix of competencies, from telecom engineering to theoretical physics, from theoretical computer science to mechanical and electronic engineering. First applications have already found their way to niche markets and university labs are working on futuristic quantum networks, but most of the surprises are still ahead of us. Quantum communication, and more generally quantum information science and technologies, are here to stay and will have a profound impact on the XXI century.
Impact Evaluation of the Health Optimizing Physical Education (HOPE) Curriculum: Towards Program Enhancement and Capacity Building
Creators: name: Gabunilas, Joana Marie Carina
Publisher: name: Zenodo
Year: 2023

description: Health Optimizing Physical Education (HOPE) is an integral component of the Senior High School curriculum, aiming to empower students with essential knowledge, skills, and competencies to lead active and healthy lives. This study investigates the implementation and impact of the HOPE program seven years after its introduction, with a specific focus on the curriculum's four components: Exercise for Fitness (HOPE 1), Sports (HOPE 2), Dance (HOPE 3), and Recreational Activities (HOPE 4). The research explores the extent to which these components have been effectively executed and whether they have contributed to students' physical and health literacy. This research uses a mixed-method approach, collecting quantitative data through a questionnaire to assess curriculum implementation and teaching ability in the HOPE program, followed by a qualitative phase involving Focus Group Discussions with teachers. According to the findings, the curriculum has been implemented to a moderate to limited extent. There is a significant difference in the implementation of HOPE 1 and 2 curricula between private and public-school institutions, but no significant differences in HOPE 3 and 4 as perceived by both teachers and students. Based on these findings, the study suggests conducting workshops to enhance HOPE 2 and 4, organizing LAC sessions for teachers to share best practices in PE 2 and 4, establishing partnerships for accessing public spaces, and launching a ""Family Activity Challenge"" to promote physical activity and family bonding through portfolio submissions.
A new look at adapted complex structures
Creators: name: Lempert, László
name: Szőke, Róbert
Publisher: name: arXiv
Year: 2010
Subjects: subject: Complex Variables (math.CV)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 32Q15, 53C20, 53C22

description: Given a closed real analytic Riemannian manifold, we construct and study a one parameter family of adapted complex structures on the manifold of its geodesics.
description: 8 pages
Time-series variation and attribution analysis of downward shortwave radiation over the Yunnan-Kweichow plateau from 1984 to 2018
Creators: name: Cheng, Lijia
name: Tang, Bo-Hui
name: He, Zhiwei
name: Fu, Zhitao
name: Li, Menghua
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: The downward shortwave radiation (DSR) is a key input parameter for land surface models and climate models. Based on the daily averaged Global Land Surface Satellite downward shortwave radiation (GLASS-DSR) dataset over the Yunnan-Kweichow Plateau (YKP) from 1984 to 2018, this paper analyzes variation trend and breakpoints of DSR. The results show that: annual averaged DSR decreases at a decreasing rate of −1.84 W·m−2·decade−1 over the YKP from 1984 to 2018; the overall distribution of interannual averaged DSR shows higher in the mid-west, and gradually decreasing from west to northeast over the YKP; the estimated averaged DSR is larger in spring than in summer due to the influence of the monsoon; monthly averaged DSR reaches its maximum in May and its minimum in December; breakpoints are found in the seasonal and trend components of daily averaged DSR. Eleven driving factors are examined for their effects on DSR variation, including annual average temperature, precipitation, 10 m wind speed, aerosol optical thickness (AOT), total cloud cover, elevation, slope, aspect, longitude, latitude, and climate zones. According to the findings, AOT predominates in the spatio-temporal distribution of DSR over the YKP. This study will contribute to studies related to climate change and highland radiation.
The effect of curvature in thawing models
Creators: name: del Campo, Sergio
name: Cardenas, Victor H.
name: Herrera, Ramon
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the evolution of spatial curvature for thawing class of dark energy models. We examine the evolution of the equation of state parameter, $w_ϕ$, as a function of the scale factor $a$, for the case in which the scalar field $ϕ$ evolve in nearly flat scalar potential. We show that all such models provide the corresponding approximate analytical expressions for $w_ϕ(Ω_ϕ,Ω_k)$ and $w_ϕ(a)$. We present observational constraints on these models.
description: 14 pages, 6 figures. Accepted for publication in Phys. Lett. B
Fitness Level and Academic Performance of BPED Students: Basis for  Student's Fitness and Academic Enhancement
Creators: name: Cabataña, Chrismarilene
Publisher: name: Zenodo
Year: 2023

description: Physical activity is an essential factor that may improve both physical and psychological well-being, such as developing a good body image, alleviating depression, and boosting life satisfaction. Furthermore, there is evidence that physical activity improves IQ and brain development. Intelligence is defined as ""the individual's aggregate or global capacity to act intentionally, think logically, and interact successfully with his environment."" This study determines the impact of the level of fitness on the academic performance of Bachelor of Physical Education (BPED) students in Arellano University College of Education in Jose Abad Santos Campus. The level of fitness-focused on body composition, flexibility, muscular strength, and cardiovascular endurance. The academic performance is not limited to the major courses offered in the semester which are the Personal, Community, Environmental Health, Safety Education, Principles of Motor Control and Learning Exercise, and Sports, and Philosophical and Socio-Anthropological Foundation of Physical Education and Sports. The researchers utilized quantitative design, mainly focused on the descriptive correlational method. It involves ten students who were enrolled in the program. The findings show that most of the respondents recorded above average in terms of flexibility, muscular strength, and cardiovascular endurance. It also reveals that all the respondents have a normal classification in terms of body mass index. In academic performance, the major course Principles of Motor Control and Learning Exercise, and Sports has the lowest grades attained by the respondents while the Personal, Community, Environmental Health, and Safety Education has the highest grades attained. The overall findings of this study revealed that fitness level and academic performance of BPED students are significantly correlated.
Экономический рост и стандартная модель внешней торговли: теоретический аспект
Creators: name: Гичиев Н.С.
name: Гичиев А.Н.
name: Закариева М.Н.
Publisher: name: Вопросы структуризации экономики
Year: 2018
Subjects: ЭКОНОМИЧЕСКИЙ РОСТ
РЕГИОН
СТАНДАРТНАЯ МОДЕЛЬ ВНЕШНЕЙ ТОРГОВЛИ

description: В статье рассматривается стандартная модели внешней торговли в аспекте ее применения для анализа теоретических основ влияния международной экономической интеграции по каналам внешней торговли на экономический рост макрорегиона. Отмечается, что, согласно теории Д.Рикардо, страны выигрывают от торговли, если они относительно разные по своей продуктивности.
Modulating neurexin-1 boosts glutamatergic transmission
Creators: name: Zuo, Long
Publisher: name: University of British Columbia
Year: 2025

description: Neurons communicate using a specialized junction called the synapse, whose properties are regulated by synaptic organizing molecules. Neurexin is one of the most studied synaptic organizers and is critical for both inhibitory and excitatory synaptic transmission and mouse survival. NRXN1 encoding one of three neurexin proteins is amongst the strongest risk genes for schizophrenia, Tourette’s Syndrome, and autism spectrum disorder (ASD). Neurexin-1 organizes the synapse by interacting with distinct postsynaptic ligands, many of which are themselves important for synaptic development. Neurexin-1 generates 3 forms from 3 promoters, all of which undergo heparan sulfate (HS) modification, a rare glycan modification essential for normal neurexin-ligand interaction. Six alternative splice sites (S1-S6) further diversify neurexin-1 structure. The most studied S4 modulates specific neurexin-ligand interactions to shape transmission and behavior in mice. Little is known, however, about S5 present in all three forms of neurexin-1 or the relationship between alternative splicing and HS modification. An understanding of these regulatory mechanisms might offer insights for developing therapeutic strategies. In chapter 2, we report a novel mechanism in which neurexin-1 S5 and HS modification jointly fine-tune synaptic transmission. When included, S5 confers a three-residue sequence that increases the number of HS chains. This is accompanied by reductions in neurexin-1 protein level and glutamatergic transmission but no change in binding affinities with canonical postsynaptic ligands. Conversely, mice in which neurexin-1 was engineered to lack S5 showed boosted synaptic neurotransmitter release without changes in postsynaptic receptor ratios. These mice were also behaviorally shifted away from phenotypes associated with ASD. While NRXN1 heterozygous deletion is frequently observed in ASD patients, functional and mechanistic studies have been limited, restricting the development of effective therapeutic strategies. Therefore, we generated mice with heterozygous loss of Nrxn1 and characterized deficits in neurexin-1 protein level and synaptic transmission. We then engineered the remaining Nrxn1 allele to lack S5 and observed alleviation of deficits due to neurexin-1 haploinsufficiency. In chapter 4, we discuss future experiments for a clearer mechanistic understanding of neurexin-1 regulation and how to combine the present discovery with existing technology to develop therapeutic strategies for deficits associated with NRXN1 deletion in patients.
On the $c^{2}$ term in the holographic formula for dark energy
Creators: name: Radicella, Ninfa
name: Pavon, Diego
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It is argued that the $c^{2}$ term that appears in the conventional formula for holographic dark energy should not be assumed constant in general. Notwithstanding, there is at least an exception, namely, when the Ricci scale is chosen as the infrared cutoff length.
description: 10 pages, 1 figure
Complete Characterization of the Ground Space Structure of Two-Body Frustration-Free Hamiltonians for Qubits
Creators: name: Ji, Zhengfeng
name: Wei, Zhaohui
name: Zeng, Bei
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The problem of finding the ground state of a frustration-free Hamiltonian carrying only two-body interactions between qubits is known to be solvable in polynomial time. It is also shown recently that, for any such Hamiltonian, there is always a ground state that is a product of single- or two-qubit states. However, it remains unclear whether the whole ground space is of any succinct structure. Here, we give a complete characterization of the ground space of any two-body frustration-free Hamiltonian of qubits. Namely, it is a span of tree tensor network states of the same tree structure. This characterization allows us to show that the problem of determining the ground state degeneracy is as hard as, but no harder than, its classical analog.
description: 5pages, 3 figures
Frankl, V., Torrelò, G., Wright, J., Sacerdocio e senso della vita. Ed. Ares. Col. «Sagitta», n. 17. Vol. de 93 ps. 113x220. Milano 1970
Creators: name: S., C.
Publisher: name: Theologica
Year: 1975

description: Theologica, v. 10 n. 2 (1975)
TRIPLE Deliverable: D2.3 Report on Machine Learning
Creators: name: Matuška, Ondřej
name: Capelli, Laurent
Publisher: name: Zenodo
Year: 2022
Subjects: SSH
social sciences and humanities
research infrastructure
OPERAS
TRIPLE

description: This deliverable describes the work implemented in the task 2.3 Machine learning. This task provided support for machine learning training on classification of SSH documents according to MORESS classification of disciplines1. Native speaker researchers were asked to provide at least 100 documents per language and per discipline to train the system via machine learning and have been involved in the training phase of the system. The task also established how the machine learning results will be later integrated in the TRIPLE environment through the work of WP4 (Building of the platform). Due to the postponement of the use of the classification model in the processing chain, the original submission date (September 30) has been moved to the end of December 2021. This draft version will be then prepared before the end of the Second reporting period and will be updated once the classification model has been completed.
description: The deliverable awaits official approval by the Project Officer. --- The TRIPLE project (https://project.gotriple.eu/), which is financed under the Horizon 2020 framework (https://cordis.europa.eu/project/id/863420), under Grant Agreement No. 863420, with approx. 5.6 million Euros for a duration of 42 months (2019-2023). --- At the heart of the project is the development of the GoTriple platform (https://www.gotriple.eu/), an innovative multilingual and multicultural discovery solution.
Solvent extraction of nickel from complexation leachate solution
Creators: name: Xiao, Yuchang
Publisher: name: University of British Columbia
Year: 2023

description: Hydrometallurgy uses aqueous solution chemistry for the recovery of metals from various materials. Complexation leaching uses chelating agents to bind targeted metals. Solvent extraction may then be used to recover and separate the target metal. This work focuses on the solvent extraction of nickel from complexation leaching solution. LIX 84-I was selected as an extractant to effectively recover nickel from near neutral leach solution in the presence of the complexing ligand. The recovery of nickel is determined by the thermodynamic relationship between the metal-ligand and metal-extractant formation. The factors that influence the thermodynamic equilibrium were investigated. The phase ratio (A/O) was studied. Solvent extraction involves the mixing and contact of an aqueous and organic solution. The kinetics of solvent extraction are therefore very important to minimize the equipment size and time for phase transfer. Thus, reaction time and temperature were studied. The stability of the ligand in the solvent extraction process was also investigated. Results show that nickel ion/citrate ligand is suitable for the solvent extraction of nickel due to the ease of loading on the extractant LIX 84-I and the ability to fully strip nickel at room temperature. However, a portion of citrate ligand is lost during the contact. The recycling and reusing of citrate ligand in the leaching process are therefore not ideal. Similarly, the loss of nitrilotriacetic acid ligand during the solvent extraction at high temperatures is measurable and therefore of concern. In comparison, ethylenediaminetetraacetic acid, ethylenediamine-N,N‘-disuccinic acid, and tetrasodium glutamate diacetate ligands are more stable during the solvent extraction process, but the kinetics of nickel extraction are too slow to permit industrial processing. It is recommended that additional factors such as higher temperature are explored to improve kinetics of nickel extraction (within the limits of safety).
UTILIZATION OF PECHA KUCHA POWERPOINT PRESENTATION METHOD TO ENHANCE THE 21ST CENTURY LEARNING SKILLS OF BPED STUDENTS
Creators: name: Bathan, Markdon
name: Montialto, Mena
name: Bunquin, Karen
Publisher: name: Zenodo
Year: 2023

description: Education fosters the discipline of enabling learning and enhancing performance through the development and management of effective instructional methodologies. The primary force behind a high-quality education relies on teaching and learning styles by integrating new ideologies aligned with the needs of 21st century learners. This study focuses on determining the distinct features of the Pecha Kucha presentation method. It also assessed the effect of the Pecha Kucha method in terms of the 4Cs, namely communication, critical thinking, collaboration, and creativity, and ascertained its relationship to its utilization. A descriptive method of research was utilized in the study. Results showed that Pecha Kucha offers adaptive responses to continue delivering lectures. Articulation of thoughts and ideas, generation of opinions on different topics, innovation and open dialogue, and creation of a power point presentation in general are highly effective through the use of a Pecha Kucha presentation. Moreover, the method was seen as essential in presenting lessons during synchronous and asynchronous sessions, seminars, and other school endeavors. Since there is a strong positive correlation between the effect and utilization, the PK RISE program was proposed. It was deemed to facilitate the widespread utilization of Pecha Kucha PowerPoint presentations in the institution, which will be of great help in enhancing the 4Cs among learners. Lastly, a similar study may be conducted to strengthen this piece of work.
Critical Zeeman Splitting of a Unitary Fermi Superfluid
Creators: name: He, Lianyi
name: Zhuang, Pengfei
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We determine the critical Zeeman energy splitting of a homogeneous Fermi superfluid at unitary in terms of the Fermi energy $ε_{\text F}$ according to recent experimental results in LKB-Lhomond. Based on the universal equations of state for the superfluid and normal phases, we show that there exist two critical fields $H_{c1}$ and $H_{c2}$, between which a superfluid-normal mixed phase is energetically favored. Universal formulae for the critical fields and the critical population imbalance $P_c$ are derived. We have found a universal relation between the critical fields and the critical imbalances: $H_{c1}=γξε_{\text F}$ and $H_{c2}=(1+γP_c)^{2/3}H_{c1}$ where $ξ$ is the universal constant and $γ$ is the critical value of the chemical potential imbalance in the grand canonical ensemble. Since $ξ$, $γ$ and $P_c$ have been measured in the experiments, we can determine the critical Zeeman fields without the detail information of the equation of state for the polarized normal phase. Using the experimental data from LKB-Lhomond, we have found $H_{c1}\simeq0.37ε_{\text F}$ and $H_{c2}\simeq0.44ε_{\text F}$. Our result of the polarization $P$ as a function of the Zeeman field $H/ε_{\text F}$ is in good agreement with the data extracted from the experiments. We also give an estimation of the critical magnetic field for dilute neutron matter at which the matter gets spin polarized, assuming the properties of the dilute neutron matter are close to those of the unitary Fermi gas.
description: Version to appear in Physical Review B
Dark solitons in atomic Bose-Einstein condensates: from theory to experiments
Creators: name: Frantzeskakis, D. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: This review paper presents an overview of the theoretical and experimental progress on the study of matter-wave dark solitons in atomic Bose-Einstein condensates. Upon introducing the general framework, we discuss the statics and dynamics of single and multiple matter-wave dark solitons in the quasi one-dimensional setting, in higher-dimensional settings, as well as in the dimensionality crossover regime. Special attention is paid to the connection between theoretical results, obtained by various analytical approaches, and relevant experimental observations.
description: 82 pages, 13 figures. To appear in J. Phys. A: Math. Theor.
Теоретические Вопросы повышения эффективности социально-экономической политики государства
Creators: name: Багомедов М.А.
Publisher: name: Вопросы структуризации экономики
Year: 2018
Subjects: СОЦИАЛЬНО-ЭКОНОМИЧЕСКАЯ ПОЛИТИКА ГОСУДАРСТВА
РЕГИОНАЛЬНАЯ ЭКОНОМИКА
ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
ФИНАНСОВАЯ ОЛИГАРХИЯ

description: В статье рассмотрены теоретические вопросы повышения эффективности социально-экономической политики государства. Делается прогноз, что экономическая депрессия в стране будет продолжаться, пока на внутреннюю политику страны будет оказывать решающее значение финансовая олигархия.
Topological superconductivity in twisted 2D structures
Creators: name: Tummuru, Tarun Reddy
Publisher: name: University of British Columbia
Year: 2023

description: The notion of twisting and stacking two-dimensional van der Waals materials has emerged as a paradigm for realizing novel electronic states. With the goal of engineering topological superconductivity, we go beyond the archetypal example of twisted bilayer graphene and consider structures composed of proximitized quantum wires and high-Tc cuprate superconductors. On the basis of symmetry arguments, backed by microscopic modeling, these setups are predicted to spontaneously break time-reversal symmetry and give rise to topological p- and d-wave phases with chiral Majorana edge modes. Given the experimental pertinence, we investigate a suite of Josephson transport phenomena in twisted cuprate bilayers and identify signatures of the topological phase. Further, the analysis is extended to twisted multilayers where the occurrence of higher-order band crossings makes the groundstate susceptible to secondary instabilities and topological superconductivity appears for an extended range of twists.
Stable operation with gain of a double phase Liquid Argon LEM-TPC with a 1 mm thick segmented LEM
Creators: name: Badertscher, A.
name: Curioni, A.
name: Horikawa, S.
name: Knecht, L.
name: Lussi, D.
name: Marchionni, A.
name: Natterer, G.
name: Resnati, F.
name: Rubbia, A.
name: Viant, T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: In this paper we present results from a test of a small Liquid Argon Large Electron Multiplier Time Projection Chamber (LAr LEM-TPC). This detector concept provides a 3D-tracking and calorimetric device capable of charge amplification, suited for next-generation neutrino detectors and possibly direct Dark Matter searches. During a test of a 3~lt chamber equipped with a 10$\times$10~cm$^2$ readout, cosmic muon data was recorded during three weeks of data taking. A maximum gain of 6.5 was achieved and the liquid argon was kept pure enough to ensure 20~cm drift (O(ppb)~O$_2$ equivalent).
description: 7 pages, 6 figures, to appear in Proc. of 1st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment (GLA2010), Tsukuba (Japan), March 2010
COGNIZANCE OF BSESS STUDENTS OF THEIR PROGRAM: BASIS FOR STRENGTHENING PHYSICAL EDUCATION
Creators: name: Bunquin, Karen
name: Bathan, Markdon
name: Montialto, Mena
Publisher: name: Zenodo
Year: 2023

description: Physical Education develops fitness and fosters the desire for lifelong participation in physical activity. It prepares students to become highly proficient in one or more physical and/or fitness activity of their choice. This study focuses on the performance of sixty – three students on the initial implementation of BSESS program. It is also intended to determine the problems encountered by the students on the program which will serve as a basis to propose immediate actions to strengthen Physical Education. The descriptive type of research was utilized in the study. The results showed that the BSESS students were involved in the course in form of exercise though there are limited Sport Sciences laboratory and textbooks available in the school library. So, respondents allocate less time in studying Sports Science, Sports Coaching and Management. With that, benchmarking, program shift and student's seminar and workshops are seen as immediate actions to strengthen Physical Education. The school administration may initiate programs and activities to increase students' participation in Physical Education.
Основные направления совершенствования ресурсного потенциала региона
Creators: name: Курбанова Умукусум Али-Искандеровна
Publisher: name: Вопросы структуризации экономики
Year: 2018
Subjects: РЕСУРСНЫЙ ПОТЕНЦИАЛ
ЭФФЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЯ

description: В статье представлены основные направления совершенствования ресурсного потенциала региона, рассмотрены различные сценарии развития, а также приоритетные мероприятия в сфере совершенствования отдельных составляющих ресурсного потенциала региона. Объектом исследования является ресурсный потенциал экономики региона. Предметом исследования выступают организационно-экономические и управленческие отношения, возникающие в процессе управления ресурсным потенциалом экономики региона.
Методика оценки дифференциации социально-экономического развития регионов на основе одного показателя
Creators: name: Амирова Эльмира Амировна
Publisher: name: Вопросы структуризации экономики
Year: 2018
Subjects: ОЦЕНКА
МЕТОДИКА
СОЦИАЛЬНО-ЭКОНОМИЧЕСКАЯ ДИФФЕРЕНЦИАЦИЯ
ПОКАЗАТЕЛЬ ДИФФЕРЕНЦИАЦИИ
РЕСУРСНЫЙ ПОТЕНЦИАЛ

description: В статье рассматривается подход к оценке дифференциации социально-экономического развития, основанного на сравнении регионов по одному показателю, выделенному в качестве главного.
Ramsey, A. M., Dieu, le Christ et le monde. Ed. Casterman. Col. «Christianisme en mouvement», n. 11. Vol. de 138 ps. 120x200. Tonrnai 1969
Creators: name: S., C.
Publisher: name: Theologica
Year: 1975

description: Theologica, v. 10 n. 2 (1975)
Two dimensional dynamical systems which admit Lie and Noether symmetries
Creators: name: Tsamparlis, Michael
name: Paliathanasis, Andronikos
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We prove two theorems which relate the Lie point symmetries and the Noether symmetries of a dynamical system moving in a Riemannian space with the special projective group and the homothetic group of the space respectively. The theorems are applied to classify the two dimensional Newtonian dynamical systems, which admit a Lie point/Noether symmetry. Two cases are considered, the non-conservative and the conservative forces. The use of the results is demonstrated for the Kepler - Ermakov system, which in general is non-conservative and for potentials similar to the Hènon Heiles potential. Finally it is shown that in a FRW background with no matter present, the only scalar cosmological model which is integrable is the one for which 3-space is flat and the potential function of the scalar field is exponential. It is important to note that in all applications the generators of the symmetry vectors are found by reading the appropriate entry in the relevant tables.
description: 25 pages, 17 tables
Benoit, Bobrinskoy e Coudreau, Baptême, sacrament d´Unité. Ed. Mame. Vol. de 222 ps. 140x215. Tours 1971
Creators: name: Faria, Manuel Ferreira De
Publisher: name: Theologica
Year: 1975

description: Theologica, v. 10 n. 2 (1975)
Проблемы управления рынком труда в субъектах Северо-Кавказского федерального округа
Creators: name: Гимбатов Шамиль Магомедович
Publisher: name: Вопросы структуризации экономики
Year: 2018
Subjects: ЫНОК ТРУДА
СКФО
ЗАНЯТОСТЬ
БЕЗРАБОТИЦА
ДЕМОГРАФИЯ

description: В статье проанализированы основные социально-экономические тенденции, воздействующие на формирование региональных особенностей и характера проблем на рынке труда Северо-Кавказского федерального округа. Выделены основные направления государственной политики в области регулирования социально-трудовой сферы.
Metz, J. B., Antropocentrismo cristano. Ed. Sígueme. Col. «Verdad e imagen», n. 23. Vol. de 168 ps. 120x190. Salamanca 1972
Creators: name: S., C.
Publisher: name: Theologica
Year: 1975

description: Theologica, v. 10 n. 2 (1975)
Daniélou, J. e Pozo, C., Iglesia y secularización. La Editorial Catolica, S.A. Col. BAC Minor, n. 23. Vol. de VIII+187 ps. 115x175. Madrid 1971
Creators: name: S., C.
Publisher: name: Theologica
Year: 1975

description: Theologica, v. 10 n. 2 (1975)