Metadata supporting data files of the related article: Success rates of re-excision after positive margins for invasive lobular carcinoma of the breast
Creators: name: Merisa L. Piper
name: Wong, Jasmine
name: Fahrner-Scott, Kelly
name: Ewing, Cheryl
name: Alvarado, Michael
name: Esserman, Laura J
name: Mukhtar, Rita A.
Publisher: name: figshare
Year: 2019
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: Cancer
subject: Medicine
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

description: The study determined the success rate of re-excision lumpectomy in women with invasive lobular carcinoma (ILC) and positive margins after surgical resection.<br> <b>Data access: </b>Dataset <b>ILC database 7.6.18.xls </b>supporting all four tables in the published article is not publicly available to protect patient privacy, but these data can be accessed from the corresponding author, Dr. Rita Mukhtar, MD; University of California San Francisco; email address: rita.mukhtar@ucsf.edu, on request. This dataset will only be made available to authorized researchers who have obtained institutional review board (IRB) approval from their own institution and from the UCSF IRB.<br> <b>Study approval: </b>This study was approved by the Institutional Review Board at the University of California, San Francisco.<br> <b>Study aims and methodology:</b> This was a single institution cohort study involving 314 cases of stage I-III ILC treated with breast conserving surgery (BCS) at the University of California, San Francisco. The authors queried a prospectively maintained surgical database and the pathology archives at the University of California, San Francisco to identify patients with the diagnosis of ILC. They identified 675 cases of ILC treated between 1992 and June 2018. After excluding those with missing surgical treatment data, de novo stage 4 disease, those missing data for margin status at first or second excision, those undergoing initial mastectomy, and those receiving neoadjuvant therapy, a total of 314 cases were included in the analysis. The primary goal of this study was to determine the success rate of re-excision lumpectomy for positive margins after partial mastectomy for ILC. The secondary goals were to identify factors associated with successful re-excision lumpectomy, to determine the impact of persistently positive margins on disease free survival (DFS), and lastly, to evaluate changes in the incidence and management of positive margins before and after margin consensus guidelines of 2014.<br> Patient data collected were patient demographics, operative details involving the initial and all subsequent breast cancer operations, pathology findings, and outcomes including time to local or distant recurrence.<br> Surgical procedures, pathology reports, and outcomes were analysed using univariate and multivariate statistics and Cox-proportional hazards models. The authors evaluated outcomes before and after the year 2014, when new margin management consensus guidelines were published. For more details on the methodology, please refer to the published article. <br> <b>Data supporting tables: </b>Data file<b> </b><b>ILC database 7.6.18.xls </b>is in Excel file format, contains clinical outcome data, and supports tables 1, 2, 3 and 4 of the published article. The file includes patient and tumor characteristics, factors associated with successful re-excision lumpectomy, Cox proportional hazards model for disease-free survival (DFS) and ILC margin status and management before and after the consensus guidelines of 2014. <b> </b> <b> </b>