cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ZrCl4 Mediated synthesis of 1,2,3-triazoles from vinyl nitrates and their biological evaluation
Creators: name: Gattu Sridhar
name: Mudavath Somnath
name: Gangavaram V. M. Sharma
name: Thodupunuri Prashanth
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Plant Biology

description: A ZrCl4 mediated simple method for the conversion of vinyl nitrates to 1,2,3-triazoles in excellent yields is developed. The obtained new triazoles were evaluated for their anti-microbial activity.
A comparison of nanoparticle-antibody conjugation strategies in sandwich immunoassays
Creators: name: Tam, Justina O.
name: Puig, Helena De
name: Chun-Wan Yen
name: Bosch, Irene
name: Gómez-Márquez, Jose
name: Clavet, Charles
name: Hamad-Schifferli, Kimberly
name: Gehrke, Lee
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Point-of-care (POC) diagnostics such as lateral flow and dipstick immunoassays use gold nanoparticle (NP)-antibody conjugates for visual readout. We investigated the effects of NP conjugation, surface chemistries, and antibody immobilization methods on dipstick performance. We compared orientational, covalent conjugation, electrostatic adsorption, and a commercial conjugation kit for dipstick assays to detect dengue virus NS1 protein. Assay performance depended significantly on their conjugate properties. We also tested arrangements of multiple test lines within strips. Results show that orientational, covalent conjugation with PEG shield could improve NS1 detection. These approaches can be used to optimize immunochromatographic detection for a range of biomarkers.
title: ISTCP 2019: 10th Triennial Congress of the International Society for Theoretical Chemical Physics
Creators: name: Hill, Grant
Publisher: name: University of Southampton
Year: 2019

description: This seven-day conference mainly consisted of a mixture of plenary lectures and parallel presentation sessions, with two poster sessions and a session on European Research Council funding. Each day had two coffee breaks and time for lunch, which, combined with the poster sessions, allowed time for networking. The conference was broad in its overall scope â covering most aspects of theoretical chemical physics / physical chemistry, but three sessions were dedicated to machine learning / AI. A number of talks within other sessions also contained significant AI for chemical discovery content too.
Efeitos dos fogos florestais nos sistemas aquáticos
Creators: name: Silva, Vera
name: Pereira, Joana Luísa
name: Gonçalves, Fernando
name: Keizer, Ian Jacob
name: Abrantes, Nelson
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: Os incêndios florestais constituem um fenómeno cada vez mais frequente nos países mediterrânicos. Portugal não é exceção, tendo-se observado nas últimas décadas um aumento do número de ocorrências e área ardida. As severas consequências sociais, económicas e ecológicas dos incêndios florestais são amplamente reconhecidas, mas alguns dos seus impactos, nomeadamente os impactos após fogo na qualidade da água, não têm merecido o relevo científico adequado. Neste trabalho pretende avaliar-se os efeitos nefastos de escorrências superficiais provenientes de áreas ardidas, ricas em metais e hidrocarbonetos aromáticos policíclicos, nos ecossistemas aquáticos. Para tal sugere-se a preparação de extratos aquosos de cinzas (em alternativa às escorrências naturais), uma matriz relativamente fácil de recolher em qualquer zona ardida, cuja toxicidade pode ser testada com diversos organismos-teste sinalizadores de efeitos adversos nos ecossistemas aquáticos. No caso particular do presente trabalho, utilizou-se um teste de inibição de crescimento da macrófita Lemna minor, uma espécie fotoautrotrófica comummente encontrada em massas de água doce superficiais em Portugal. Estudos anteriores revelam a sensibilidade desta espécie a escorrências de incêndios e alertam para repercussões das mesmas no normal funcionamento do ecossistema aquático.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
O espaço público e as pessoas – Baixa de Algés
Creators: name: Vaz, Simone C. D.
name: Lima, Fábio J.M. De
name: Nicolau, Paula B.
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: As cidades concentram pessoas que circulam pelas ruas, um espaço público que tem o privilégio de permear toda a cidade e que é potencialmente um elemento integrador. As ruas têm resgatado uma importante função social, revelando-se um lugar de estadia e convívio, onde os citadinos podem interagir entre si e com o ambiente. Quando as ruas estão preparadas para adotarem essas funções, são estabelecidas novas dinâmicas que promovem as vertentes da sustentabilidade – a ambiental, a social, a económica e também a cultural. Neste contexto, este trabalho, aborda a escala humana do planeamento urbano, como elemento promotor do desenvolvimento sustentável. Procedeu-se ao estudo de caso de um trecho do espaço público da Baixa de Algés, no Concelho de Oeiras, em Portugal, no que respeita às transformações do seu uso e morfologia, durante a vigência do atual Plano Diretor Municipal (PDM), desde 1994 até 2014. A partir de um estudo exploratório, abarcado por visitas ao local, pesquisa documental e aplicação de inquéritos, foi possível perceber as suas caraterísticas, as intervenções realizadas e a perceção das pessoas relativamente às mesmas, e concluir que o desenho atual desse trecho do espaço público não fomenta dinâmicas que promovam o desenvolvimento sustentável.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
Madeira morta, mas cheia de vida: uma proposta de educação ambiental
Creators: name: Almeida, Ana Rita
name: Novais, Ana Teresa
name: Flávio, Hugo
name: Oliveira, Sofia Da Silva
name: Pereira, Ruth
name: Santos, Paulo Talhadas Dos
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: A “verdadeira” madeira morta – ou seja, aquela com diâmetro superior a 6-7 cm – fornece variados serviços de ecossistema importantes, entre os quais o fornecimento de habitat para diversos seres vivos, desempenhando assim um papel essencial no ecossistema florestal. Adicionalmente, ao contrário da ideia de que a madeira morta fornece um contributo relevante para o aumento do risco de incêndio, esta na verdade está relacionada com fogos menos frequentes e de menor intensidade. No entanto, em Portugal, a remoção da madeira morta constitui uma componente importante da limpeza florestal como forma de prevenção de incêndios. Assim, torna-se essencial alterar as correntes práticas nacionais de gestão florestal, de forma a promover a conservação da madeira morta. Neste sentido, o presente artigo apresenta uma proposta de um projeto de educação ambiental que pretende (1) sensibilizar a população em geral e os profissionais ligados à área florestal para esta temática, (2) aumentar a informação disponível sobre a madeira morta e sua biodiversidade – que é escassa no universo científico – e ainda (3) alterar efetivamente as correntes práticas de limpeza florestal de forma a torna-las compatíveis com a proteção da madeira morta e da comunidade que esta alberga.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
Catechol reactivity: Synthesis of dopamine derivatives substituted at the 6-position
Creators: name: Rote, Jennifer C.
name: Malkowski, Sarah N.
name: C. Skyler Cochrane
name: Bailey, Gabrielle E.
name: Brown, Noah S.
name: Cafiero, Mauricio
name: Larryn W. Peterson
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Dopamine is a ubiquitous neurotransmitter essential in the proper functioning of the human body. In addition to this critical role, the catecholamine core has shown utility as a scaffold for numerous drugs and in other applications, like metal detection and adhesive materials. Substituents at the 6-position of dopamine’s catechol core can modulate its stereoelectronic properties, the acidity of its phenolic hydroxyl groups, and the overall hydrophobicity of the molecule. Herein, we report the synthesis of a series of four novel dopamine analogues substituted at the 6-position of catechol core. The 1H NMR chemical shift of the aromatic proton meta to the substituent correlated strongly with the Hammett σm constant, confirming the electronic properties of substituents.
Application of Boronic Acids in Medicinal Chemistry (Inhibitors, Sensors)
Creators: name: Ni, Nanting
Publisher: name: Georgia State University
Year: 2010

description: It is well known boronic acids have its unique chemistry and related applications in organic synthesis. The boronic acid functionally group also plays very important roles in medicinal chemistry and chemical biology. For example, boronic acids have been developed as potential therapeutic agents, chemical biology tools. All these applications are directly related to the unique electronic and chemical properties of the boronic acid group. Herein, several application of boronic acids have been studied: 1) several groups of compounds were found as bacterial quorum sensing inhibitors; 2) a boronate compound was developed as a probe for detecting reactive oxygen species (ROS); and 3) boronic acid-modified aptamers can be used for glycoprotein recognition.
Development of RNA Microchip for the Detection of Pathogens
Creators: name: Spencer, Sarah
Publisher: name: Georgia State University
Year: 2010

description: Detection of cellular messenger RNA is a useful diagnostic strategy for the detection of patho-gens. A rapid and sensitive method for on-site detection of specific pathogens would be of great use in a number of fields. For example, a simple and inexpensive method for the detection of harmful biological agents in train stations and airports is useful for national security. Rapid detection of pathogenic E. coli strains in food production would also be of great benefit in ensuring the safety and quality of our food supply. Here we present a method for the rapid de-tection of cellular mRNA. This system is based on the 3?-labeling approach in which targeted RNA is simultaneously extended and labeled with the use of biotin labeled-dNTPs and DNA po-lymerase on an immobilized nucleic acid probe. The biotin is subsequently converted to an enzymatic label, which produces a detectable chemiluminescent reaction in the presence of substrate. Detection time of this system is short (approximately 20 minutes) because there is no need for amplification by PCR, transcription, or fluorophore labeling. This novel methodology has been successfully demonstrated by selective detection of lac Z mRNA in a total RNA sample from E. coli.
Communicating physical activity messages with adolescents: what works? A scoping review with stakeholder consultation
Creators: name: Grady, Caera
name: Murtagh, Elaine
name: Ng, Kwok
name: García Bengoechea, Enrique
name: Woods, Catherine
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 4207
subject: Sports science and exercise

description: Background Global levels of adolescents’ physical inactivity are cause for concern, despite the well-documented health benefits of physical activity (PA). Addressing the messaging of PA is one approach to improve PA knowledge. While increased knowledge does not necessarily lead to behavior change, physically active students have better knowledge of the health benefits of PA. Recently, researchers have highlighted the need for an effective communication strategy for PA messages. This review aimed to summarize the state of the available evidence about the operationalization of communicating PA messages, the evaluation, and effectiveness of PA messages. Methods The Levac six steps and Joanna Briggs Institute methodological guidance for scoping reviews were followed. Five databases were searched up until April 8th 2024. Both title and abstract and full-text screening were piloted whereby 10% of the total articles were double-screened and the remainder were completed by CG. Data were extracted and a data-based convergent synthesis design was used following qualitative synthesis methods. Finally, a consultation with key stakeholders was held to confirm the findings concerning practical relevance. Results A total of 19,412 articles were identified from searches, 94 full texts were included in the final analysis, corresponding to 80 individual studies. The evidence confirms that there are many factors to consider when communicating PA messages and evaluating their effectiveness. Inconsistencies exist regarding the timing and frequency of message delivery and the evaluation of effective communication. When communicating PA with adolescents, messages commonly focus on the benefits of PA and strategies to overcome barriers and are commonly delivered in the school setting by researchers or school stakeholders i.e. teachers, peers. Messages should be concise, positively framed, support adolescent autonomy, and utilize different messaging platforms and techniques to avoid staleness. Conclusions There is a lack of a standardized approach to communicating PA messages with adolescents making evaluation and comparison challenging. Future research should focus on developing guidance to facilitate the effective communication of PA messages with adolescents
Madeira morta: uma revisão da importância da sua conservação
Creators: name: Almeida, Ana Rita
name: Novais, Ana Teresa
name: Flávio, Hugo
name: Oliveira, Sofia Da Silva
name: Pereira, Ruth
name: Santos, Paulo Talhadas Dos
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: A madeira morta presente nas manchas florestais é fundamental à sobrevivência de um elevado número de espécies, estando intimamente ligada à diversidade biológica presente neste tipo de ecossistema. Além disso, esta componente e a comunidade a ela associada são responsáveis pelo fornecimento de diversos serviços de ecossistema, como a produção de energia e o armazenamento de carbono, que contribuem para a valorização florestal. No entanto, apesar da importância da madeira morta, o facto de esta ser associada ao aumento do risco de incêndio conduz à sua contínua remoção das florestas durante processo de limpeza florestal. Assim, torna-se imperativo alterar as atuais práticas de gestão florestal de maneira a torná-las compatíveis com a preservação da madeira morta e das comunidades saproxílicas, assegurando também a manutenção dos serviços ecossistémicos prestados por estas. Neste sentido, o presente trabalho pretende aglomerar a escassa informação existente sobre este tópico, enquanto alerta para a importância desta componente florestal e para a necessidade de se adotarem práticas de gestão florestal compatíveis com a conservação da madeira morta.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
Synthesis of five- and six-membered cyclic guanidines by guanylation with isothiouronium iodides and amines under mild conditions
Creators: name: Aoyagi, Naoto
name: Endo, Takeshi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Cyclic guanidine hydroiodides were obtained in one step by the reactions of isothiouronium iodides with an equimolar amount of various amines in tetrahydrofuran. The obtained hydroiodides were neutralized with sodium hydroxide or anionic exchange resin to afford the corresponding substituted cyclic guanidines in quantitative yields.
Thysanopterenfänge in Giengen (Brenz), Württemberg
Creators: name: Titschak, Erich
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
“Onde estão as sementes do medronheiro?” – uma intervenção educativa com alunos no âmbito da disciplina de Ciências Naturais
Creators: name: Dias, Graça Maria Neves
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: A aprendizagem informal no ensino básico deve ser estimulada de modo a permitir aprendizagens mais intensas e sistemáticas sobre o mundo real. O projeto “Onde estão as sementes do medronheiro”, refere-se à conceção, planificação, implementação e avaliação de uma intervenção educativa, no âmbito da disciplina de Ciências Naturais, recorrendo à metodologia Inquiry Based Science Education (IBSE), com atividades de cariz prático, laboratoriais e de campo, e ações ambientais e cooperativos, envolvendo 19 alunos do Ensino Básico do concelho de Arganil. A intervenção incluiu atividades realizadas em dois contextos distintos – ao nível do ensino formal (sala de aula), e não formal, laboratório e no campo (Mata da Santa Casa da Misericórdia de Arganil), enquadrada na temática “Sustentabilidade na Terra”, centrada nos conceitos: Biodiversidade, Alterações Climáticas e Sustentabilidade. A avaliação da intervenção teve por base a recolha de dados que contemplaram a análise das respostas dos alunos às fichas de trabalho e ao questionário de avaliação, bem como os registos de observação direta e no diário do professor. Foram também integrados dados quantitativos, sob a forma de estatística descritiva. Os resultados obtidos, com este projeto, fornecem indicadores positivos em relação ao valor educativo de intervenções que promovam interações entre contextos formais e não formais, integrando inter-relações Ciências-Tecnologia-Sociedade, centradas no quotidiano dos alunos, e permitem reforçar a aplicação do método de aprendizagem ativa (IBSE) como um recurso importante na aprendizagem das Ciências Naturais.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
A influência dos efeitos maternais em invertebrados bentónicos marinhos com ciclos de vida bifásicos, com ênfase nos crustáceos decápodes
Creators: name: Rey, Felisa
name: Calado, Ricardo
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: A maioria dos invertebrados bentónicos marinhos desenvolve-se através de ciclos de vida complexos e bifásicos. Existem três momentos críticos no ciclo de vida destes organismos, que exercem uma grande influência no seu desenvolvimento: 1) investimento maternal na produção de oócitos, 2) eclosão e desenvolvimento larvar e 3) metamorfose. O sucesso de cada um destes processos vai condicionar de forma determinante a dinâmica e a evolução das populações. A complexidade dos ambientes que estes organismos ocupam, e a diversidade de fatores (bióticos e abióticos) que influenciam as distintas fases do seu ciclo de vida, torna difícil dissociar o efeito dos fatores maternais e ambientais. As reservas energéticas dos embriões aquando da eclosão ou o tamanho e perfil energético das larvas na altura da metamorfose, condicionam a sua adaptação ao meio no qual se desenvolvem e o sucesso das fases subsequentes do seu ciclo de vida. Direta ou indiretamente, os efeitos maternais condicionam o fenótipo da descendência, e influenciam a sua evolução. Embora ainda pouco estudados no meio marinho, os efeitos maternais têm um papel muito importante a nível biológico e ecológico. Nesta revisão, apresentamos os diferentes tipos de efeitos maternais e discutimos como estes atuam sobre a descendência.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
The sorption of monovalent cations onto norway spruce: Model studies using wood flour and LiCl solution
Creators: name: Reddysuresh Kolavali
name: Hasani, Merima
name: Theliander, Hans
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry

description: The transport of chemicals in a porous material such as wood is very complex and involves several processes: the diffusion of chemicals in the cell pores (lumen and pit pores), through the cell walls at certain conditions, and sorption of wood tissue. In the present study, batch sorption experiments were performed to examine the sorption of Li+ ions from an aqueous LiCl solution onto Norway spruce wood flour samples. The experimental methodology employed is suitable for differentiating the amount of ions sorbed onto the wood tissue and dissolved in the solution in wood pores. The apparent equilibrium sorption data were analyzed using two widely applied isotherm models: Langmuir and Freundlich. The results suggest that the sorption was spontaneous, and for the experimental conditions studied, probably involved several interaction types between the different functional groups of the wood and the Li+/Cl− ions.
Synthesis and Enzymatic Studies of Selenium Derivatized Nucleosides, Nucleotides and Nucleic Acids
Creators: name: Caton-Williams, Julianne
Publisher: name: Georgia State University
Year: 2009

description: Nucleoside 5-triphosphates are the building blocks to synthesis of nucleic acids. Nucleic acids (RNA and DNA) participate in many important biological functions in living systems, including genetic information storage, gene expression, and catalysis. Nucleoside 5- triphosphates have many important therapeutic and diagnostic applications. To understand how these triphosphates are utilized in living systems, numerous synthetic mimics have been prepared and used as active metabolites of certain drugs and molecular probes. Over the years, nucleic acids have been modified at the nucleobase, sugar moiety and phosphate backbone with the aim of understanding their structures and functions. We have site-specifically replaced selected oxygen atoms of nucleosides and nucleotides with selenium atom in order to enzymatically synthesize selenium-derivatized DNAs for obtaining insights into the DNA flexibility, duplex recognition and stability. Although triphosphates have important biological and medicinal significance, they are however, very difficult to synthesize and isolate in high purity and yield. There are many approaches to the synthesis of nucleoside 5-triphosphates, but there is no general strategy that allows simple and direct synthesis of nucleoside triphosphates. To face the challenges, we have developed a new approach in the absence of protecting groups to quickly and efficiently synthesized native deoxynucleoside 5-triphosphates and deoxynucleoside 5-(?ñ- P-seleno)- P-seleno)triphosphates. Syntheses of the triphosphates containing selenium-derivatized nucleobases were also successfully accomplished. After replacing the oxygen atoms at the 4-position of thymidine and uridine, and the 6-position of guanosine, we observed most strikingly, a large bathrochromic shift of over 100 nm, relative to their native counterparts of UV absorbance of 260 nm. Consequently, the synthesized selenium base modified triphosphates are yellow. We also synthesized 2-selenothymidine and 5-methylseleno thymidine 5-triphosphates. We conducted stability study on the colored 4-selenothymidine and used the 5- triphosphate analog (4-SeTTP) as substrate for polymerase recognition. The Klenow polymerase incorporated the 4-SeTTP with efficiency equal to that of the native counterpart. Finally, 4-SeTTP was used to demonstrate UVdamage resistance of selenium-derivatized DNAs and plasmid.
A vida entre dois mundos - a metamorfose não apaga a história larvar de invertebrados marinhos com ciclos de vida bifásicos
Creators: name: Rey, Felisa
name: Neto, Gina M. Silva
name: Rosa, Rui
name: Queiroga, Henrique
name: Calado, Ricardo
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: O ciclo de vida da maioria dos invertebrados marinhos alterna entre o ambiente pelágico (na coluna de água) e bentónico (no fundo). As larvas desenvolvem-se no meio pelágico, enquanto os adultos ocupam o bentos, cabendo às formas larvares realizarem a interface entre estes dois ambientes. As condições a que as larvas estão sujeitas durante o desenvolvimento e nos momentos de interface, podem influenciar a sobrevivência ou o fenótipo das mesmas, refletindo-se nas fases subsequentes do seu ciclo de vida. Neste estudo avaliámos o efeito da exposição a baixas salinidades de megalopas (último estado de desenvolvimento larvar dos caranguejos braquiúros) do caranguejo verde Carcinus maenas no momento em que estas regressam ao estuário para realizar a sua metamorfose (transição entre os modos de vida pelágico e bentónico). Foram simuladas condições resultantes de períodos de chuva intensa, que se refletem na salinidade do estuário. Deste modo, as megalopas selvagens recolhidas do plâncton foram expostas a dois tratamentos: salinidade 10 (extrema) e 25 (controlo), em condições de inanição (ausência de alimento) até morrerem ou realizarem a metamorfose. Após a metamorfose, todos os caranguejos juvenis em estádio 1 (C1) foram aclimatados a uma salinidade de 25 e mantidos em condições constantes de temperatura e alimento até caranguejo em estádio 5 (C5). Apesar da resistência das larvas à baixa salinidade, a vulnerabilidade nutricional e o custo do stress osmótico repercutiu-se no desempenho dos juvenis. Os indivíduos que foram expostos mais tempo a condições adversas, apresentaram os tamanhos mais pequenos e os pesos mais baixos, dando lugar a juvenis de menor qualidade. O início da vida bentónica é assim condicionado pela experiência pelágica, confirmando que a metamorfose não apaga a história larvar.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 2 (2016)
title: Machine Learning for Materials Science Report 2019
Creators: name: Cumby, James
Publisher: name: University of Southampton
Year: 2019
Subjects: subject: AI3SD, Workshop Report, Materials Science, Machine Learning

description: This five-day workshop consisted of a two-day school introducing machine learning techniques for materials science with a mixture of presentations and hands-on tutorials, followed by a three-day conference made up of invited presentations, contributed talks, a poster session and a number of panel discussions. The event drew participants from primarily chemistry, physics and computer science backgrounds, all with a focus on applying machine learning to materials discovery or understanding. Some of the invited talks were given by industrial participants, complementing the academic research presenting, and offering a different view. Coffee breaks and a conference dinner/poster session allowed plenty of time for networking amongst this diverse group.
Mechanisms of Cooperative Dynamics  Emerging in Interrole Conflict Situations
Creators: name: Takashi, Sato
Publisher: name: Applied Science and Computer Science Publications
Year: 2025

description: Abstract: This study explores how people manage conflict when they belong to multiple groups and decide which groups to support at a given time. We introduced a computer simulation called the interrole conflict game to mimic real-life situations in which individuals face competing demands. To represent the differences between adolescence and adulthood, we used Recurrent Q-Learning (RQL) agents that adjusted behavior based on past experiences. Our findings show that an agent’s ability to cooperate depends on how well it can predict future actions. When agents have a limited memory, they perform better by focusing on immediate rewards. In contrast, when agents can remember more information, they can plan ahead and work together more effectively over time. We also observed that gradual adjustments in the learning process using a low learning rate helped the agents become more stable and cooperative. This study provides insight into how short-term reactions and long-term planning can be balanced to improve cooperation in complex social settings.
The sorption of monovalent cations onto norway spruce: Model studies using wood flour and LiCl solution
Creators: name: Reddysuresh Kolavali
name: Hasani, Merima
name: Theliander, Hans
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry

description: The transport of chemicals in a porous material such as wood is very complex and involves several processes: the diffusion of chemicals in the cell pores (lumen and pit pores), through the cell walls at certain conditions, and sorption of wood tissue. In the present study, batch sorption experiments were performed to examine the sorption of Li+ ions from an aqueous LiCl solution onto Norway spruce wood flour samples. The experimental methodology employed is suitable for differentiating the amount of ions sorbed onto the wood tissue and dissolved in the solution in wood pores. The apparent equilibrium sorption data were analyzed using two widely applied isotherm models: Langmuir and Freundlich. The results suggest that the sorption was spontaneous, and for the experimental conditions studied, probably involved several interaction types between the different functional groups of the wood and the Li+/Cl− ions.
Die Lepidopterenfauna von Württemberg. II. Microlepidopteren. Kleinschmetterlinge (8. Fortsetzung)
Creators: name: Wörz, Albert
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1957

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 112, 1957
Catechol Reactivity: Synthesis of Dopamine Derivatives Substituted at the 6-Position
Creators: name: Rote, Jennifer C.
name: Malkowski, Sarah N.
name: C. Skyler Cochrane
name: Bailey, Gabrielle E.
name: Brown, Noah S.
name: Cafiero, Mauricio
name: Larryn W. Peterson
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Dopamine is a ubiquitous neurotransmitter essential in the proper functioning of the human body. In addition to this critical role, the catecholamine core has shown utility as a scaffold for numerous drugs and in other applications, like metal detection and adhesive materials. Substituents at the 6-position of dopamine's catechol core can modulate its stereoelectronic properties, the acidity of its phenolic hydroxyl groups, and the overall hydrophobicity of the molecule. Herein, we report the synthesis of a series of four novel dopamine analogues substituted at the 6-position of the catechol core. The 1H NMR chemical shift of the aromatic proton meta to the substituent correlated strongly with the Hammett σm constant, confirming the electronic properties of the substituents.
The application of dried blood spots in toxicokinetic and pharmacokinetic studies
Creators: name: Barfield, Matt
Publisher: name: University of Lincoln
Year: 2024
Subjects: C720 - Biological chemistry

description: Dried Blood Spot (DBS) sampling is a microsampling technique used throughout theWorld for neonatal screening. The work set out in this thesis shows the developmentand implementation of DBS in the area of preclinical and clinical pharmaceutical drugdevelopment, specifically in support of Toxicokinetics and Pharmacokinetics. Theadvantages of the technique are explored along with the issues faced. The papersdiscussed in this commentary, include in papers 1 and 2, the concept of supportingboth Toxicokinetics and Pharmacokinetics studies and the validation of bioanalyticalassays utilising DBS. Commentary paper 3 further explores the practicalities of DBS inthe Clinical environment and commentary paper 4 the transferability of DBStechnology between laboratories. Commentary paper 5 uses Incurred SampleReanalysis data to answer questions around specific DBS issues and commentary paper6 looks at indicating papers for Dried Plasma Spots. Commentary papers 7 and 8explore the use of consortia to investigate hematocrit and homogeneity when usingDBS and finally commentary paper 9 explores the training required to ensure qualityDBS samples. The impact and contributions to this field of research are demonstratedthrough discussion and critical examination of selected examples of the author’s peerreviewedpublications in this area. Developments of scientific practices, where theauthor has contributed intellectual, leadership and practical insight to achievesignificant improvements in the generation of knowledge, are highlighted throughoutthe commentary.
Supplementary document for Deep Autoencoder as an Interpretable Tool for Raman Spectroscopy Investigation of Chemical and Extracellular Vesicle Mixtures - 6904104.pdf
Creators: name: Kazemzadeh, Mohammadrahim
name: Martinez-Calderon, Miguel
name: Otupiri, Robert
name: Artuyants, Anastasiia
name: Lowe, Tiffany
name: Ning, Xia
name: Reategui, Eduardo
name: Schultz, Zachary
name: Xu, Peter Weiling
name: Blenkiron, Cherie
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary Information
The application of dried blood spots in toxicokinetic and pharmacokinetic studies
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C720 - Biological chemistry

description: Dried Blood Spot (DBS) sampling is a microsampling technique used throughout theWorld for neonatal screening. The work set out in this thesis shows the developmentand implementation of DBS in the area of preclinical and clinical pharmaceutical drugdevelopment, specifically in support of Toxicokinetics and Pharmacokinetics. Theadvantages of the technique are explored along with the issues faced. The papersdiscussed in this commentary, include in papers 1 and 2, the concept of supportingboth Toxicokinetics and Pharmacokinetics studies and the validation of bioanalyticalassays utilising DBS. Commentary paper 3 further explores the practicalities of DBS inthe Clinical environment and commentary paper 4 the transferability of DBStechnology between laboratories. Commentary paper 5 uses Incurred SampleReanalysis data to answer questions around specific DBS issues and commentary paper6 looks at indicating papers for Dried Plasma Spots. Commentary papers 7 and 8explore the use of consortia to investigate hematocrit and homogeneity when usingDBS and finally commentary paper 9 explores the training required to ensure qualityDBS samples. The impact and contributions to this field of research are demonstratedthrough discussion and critical examination of selected examples of the author’s peerreviewedpublications in this area. Developments of scientific practices, where theauthor has contributed intellectual, leadership and practical insight to achievesignificant improvements in the generation of knowledge, are highlighted throughoutthe commentary.
A Comparison of Nanoparticle-Antibody Conjugation Strategies in Sandwich Immunoassays
Creators: name: Tam, Justina O.
name: Puig, Helena De
name: Chun-Wan Yen
name: Bosch, Irene
name: Gómez-Márquez, Jose
name: Clavet, Charles
name: Hamad-Schifferli, Kimberly
name: Gehrke, Lee
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Point-of-care (POC) diagnostics such as lateral flow and dipstick immunoassays use gold nanoparticle (NP)-antibody conjugates for visual readout. We investigated the effects of NP conjugation, surface chemistries, and antibody immobilization methods on dipstick performance. We compared orientational, covalent conjugation, electrostatic adsorption, and a commercial conjugation kit for dipstick assays to detect dengue virus NS1 protein. Assay performance depended significantly on their conjugate properties. We also tested arrangements of multiple test lines within strips. Results show that orientational, covalent conjugation with PEG shield could improve NS1 detection. These approaches can be used to optimize immunochromatographic detection for a range of biomarkers.
Pesnelle, Coutume de Normandie expliquée par M. Pesnelle Avocat au Parlement. Seconde édition, Revue, corrigée & augmentée par l'Auteur : avec un recueil d'Arrêts & Règlemens, tant du Conseil que de la Cour, donnez la plûpart sur la Coûtume, ainsi qu'ils sont rangez à la fuite de la Table des Chapitres, Rouen, Besongne le fils, 1727
Creators: name: Pesnelle, Avocat Au Parlement
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: N. Pesnelle, né à Rouen dans le seconde moitié du XVIIe siècle, fut procureur du roi en la vicomté de Rouen puis avocat au parlement de Rouen. La Coutume de Normandie expliquée, parue pour la première fois en 1704, devait être par la suite augmentée des observations de Roupnel de Chenilly en 1759.
description: Source: Bibliothèque universitaire du Tertiaire de Rouen, Faculté de droit. BB4139
description: Relation: vignette : https://www.nakala.fr/data/11280/39e5b336
Genetic reconstruction of parentage and kinship in semi-feral domestic dogs, and analysis of effects of dog breeding patterns on an immune system gene MARCH7
Creators: name: Karp-Tatham, Eleanor
Publisher: name: University of Lincoln
Year: 2024
Subjects: C430 - Medical & veterinary genetics

description: Whilst there has been considerable research focusing on the kinship of wolves, data on free-ranging dogs was sparse and there has been a long standing controversial debate over their ability to form packs. One of the aims of this project was to reconstruct kinship relationships in a population of free-ranging dogs, assessing the genetic variability and inbreeding level. For this purpose, I studied a population inhabiting a nature reserve at the outskirts of Rome in Italy. Analysis of twelve microsatellite loci revealed low number of alleles per locus, low levels of heterozygosity and difficulties in assigning parentage, possibly resulting from high levels of inbreeding in the population. Results from parentage analysis suggested multiple breeding individuals to be present in the social groups. One explanation for this is a result of the domestication process as free-ranging dogs no longer follow seasonal reproductive behaviour and have a plentiful supply of human waste to scavenge reducing competition. Although parentage analysis suggested multiple paternity for two litters, results had low statistical support and could be due to low genetic variability in the population.Recent research has found MARCH7 as a common candidate gene under diversifying selection between free-breeding dogs and either East Asia or European dog breeds, with a SNP labelled in the intronic region of the gene. MARCH7 belongs to the membrane-associated RING-CH (MARCH) family, a RING finger protein family of E3 ubiquitin ligases, consisting of 11 members in mammals. The second aim of this study was to test for the possible signals of diversifying selection between free-ranging dogs, pure-breed dogs and wolves in the MARCH7 gene. This was achieved through three main routes: Sanger sequencing of a targeted region previously identified as being under selection, evolutionary comparison through investigation of nonsynonymous and synonymous patterns and phylogenetic analysis of mammalian species and ab initio prediction of protein structure . Sequence analysis demonstrated the possibility of copy number variation and alternative splicing in MARCH7 but failed to show polymorphism at the previously identified intronic SNP. Comparative analysis demonstrated MARCH7 to have highly conserved regions, most notably the RING-CH domain, but also polymorphic regions, where a multitude of both synonymous and nonsynonymous mutations are present across mammalian species studied. Comparison of nonsynonymous and synonymous mutations demonstrated MARCH7 to be under purifying selection across mammalian species. Ab initio prediction of protein structure indicated a highly disordered structure across the majority of the gene, with the exception of the RING-CH domain.
Knockout of miR-221 and miR-222 reveals common and specific targets for paralogous miRNAs
Creators: name: Geon Jeong
name: Yeong-Hwan Lim
name: Kim, Nam Joong
name: Gabbine Wee
name: Young-Kook Kim
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: MicroRNAs (miRNAs) regulate the expression of mRNA through sequence-specific binding of the 3′ untranslated region (UTR). The seed sequence of miRNAs is the key determinant for target site recognition. Paralogous miRNAs, which share the same seed sequences but differ in their 3′ regions, are known to regulate largely overlapping groups of mRNAs. However, no study has analyzed functional differences between paralogous miRNAs with proper experimental methods. In this study, we compared the targets of paralogous miRNAs, miR-221 and miR-222. Using a nuclease-mediated genome engineering technique, we established knockout cell lines for these miRNAs, and precisely analyzed differences in target regulation. We found that miR-221 and miR-222 suppress the previously identified targets, CDKN1B and CDKN1C, differentially. Whereas both miRNAs suppressed CDKN1B, only miR-221 suppressed CDKN1C. From transcriptome analyses, we found that several different target mRNAs were regulated by each of miR-221 and miR-222 independently, although a large number of mRNAs responded commonly to miR-221 and miR-222. This is the first study to compare the mRNA regulations by paralogous miRNAs and illustrate that paralogous miRNAs with the same seed sequence also have difference in target regulation.
Transcriptome profiling of the developing male germ line identifies the miR-29 family as a global regulator during meiosis
Creators: name: Hilz, Stephanie
name: Fogarty, Elizabeth A.
name: Modzelewski, Andrew J.
name: Cohen, Paula E.
name: Grimson, Andrew
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: MicroRNAs are essential for spermatogenesis. However, the stage-specific requirements for particular miRNAs in the male mammalian germ line remain largely uncharacterized. The miR-34 family is, to date, the only miRNA proven to be necessary for the production of sperm in mammals, though its germline roles are poorly understood. Here, we generate and analyze paired small RNA and mRNA profiles across different stages of germline development in male mice, focusing on time points shortly before and during meiotic prophase I. We show that in addition to miR-34, miR-29 also mediates widespread repression of mRNA targets during meiotic prophase I in the male mouse germline. Furthermore, we demonstrate that predicted miR-29 target mRNAs in meiotic cells are largely distinct from those of miR-34, indicating that miR-29 performs a regulatory function independent of miR-34. Prior to this work, no germline role has been attributed to miR-29. To begin to understand roles for miR-29 in the germ line, we identify targets of miR-29 undergoing post transcriptional downregulation during meiotic prophase I, which likely correspond to the direct targets of miR-29. Interestingly, candidate direct targets of miR-29 are enriched in transcripts encoding extracellular matrix components. Our results implicate the miR-29 family as an important regulatory factor during male meiosis.
Assessment of Sustainability Governance in Higher Education Institutions - a Systemic Tool using a Governance Equalizer
Creators: name: Niedlich, Sebastian
name: Bauer, Mara
name: Doneliene, Margarita
name: Jaeger, Larissa
name: Rieckmann, Marco
name: Bormann, Inka
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: sustainability assessment tool
subject: sustainability governance
subject: higher education institutions
subject: systems theory
subject: governance equalizer
subject: politics
subject: profession
subject: organization
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::378 Hochschulbildung

description: The paper aims to add to the discussion on sustainability governance in higher education institutions by examining the role of sustainability assessment and introducing an assessment tool inspired by systemic thinking and centered on a ‘governance equalizer’. It discusses recent research and argues that the complexity inherent in sustainability governance remains to be addressed adequately. While a number of models and frameworks have been proposed, most of them remain caught between narrow, management-oriented approaches on the one hand, and rather abstract approaches that provide little guidance for improving the field on the other. Sustainability assessment tools represent a potential way to bridge this gap. While there are existing tools which include issues of sustainability governance, these are often limited to aspects that are easily quantifiable and neglect more complex aspects. Against this background, the article proposes an alternative tool to assess sustainability governance in higher education institutions. The tool is based on a multi-case study in Germany and has been tested in a series of workshops. Drawing on the concept of a ‘governance equalizer’, it focuses on the functional requirements of sustainability governance in five dimensions - politics, profession, organization, knowledge, and the public—and how they are addressed by the HEI. The tool raises the level of abstraction in order to capture complexity, but at the same time keeps sight of governance structures, processes, instruments, and practices. It combines clearly defined criteria that are assessed using carefully developed maturity scales with a focus on stakeholder participation and knowledge.