cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Smoke in the Pipe Nebula: dust emission and grain growth in the starless core FeSt 1-457
Creators: name: Forbrich, Jan
name: Lada, Charles J.
name: Lombardi, Marco
name: Roman-Zuñiga, Carlos
name: Alves, João
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: (abridged) Methods: We derive maps of submillimeter dust optical depth and effective dust temperature from Herschel data that were calibrated against Planck. After calibration, we then fit a modified blackbody to the long-wavelength Herschel data, using the Planck-derived dust opacity spectral index beta, derived on scales of 30' (or ~1 pc). We use this model to make predictions of the submillimeter flux density at 850 micron, and we compare these in turn with APEX-Laboca observations. Results: A comparison of the submillimeter dust optical depth and near-infrared extinction data reveals evidence for an increased submillimeter dust opacity at high column densities, interpreted as an indication of grain growth in the inner parts of the core. Additionally, a comparison of the Herschel dust model and the Laboca data reveals that the frequency dependence of the submillimeter opacity, described by the spectral index beta, does not change. A single beta that is only slightly different from the Planck-derived value is sufficient to describe the data, beta=1.53+/-0.07. We apply a similar analysis to Barnard 68, a core with significantly lower column densities than FeSt 1-457, and we do not find evidence for grain growth but also a single beta. Conclusions: While we find evidence for grain growth from the dust opacity in FeSt 1-457, we find no evidence for significant variations in the dust opacity spectral index beta on scales 0.02
description: A&A, in press
รูปแบบเชิงอนาคตภาพการจัดการศึกษาภาษาจีนของโรงเรียนเอกชนระดับประถมศึกษาในประเทศไทย
Creators: name: นงลักษณ์ เดชดำเกิงชัย
name: ธงชัย สมบูรณ์
name: จารุวรรณ พลอยดวงรัตน์
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: รูปแบบอนาคตภาพ
การจัดการศึกษาภาษาจีน
โรงเรียนเอกชนสอนภาษาจีน
ระดับประถมศึกษา
The Scenario Model
Chinese Language Education Management
Private Schools
Primary Level

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 501-513
Voltage-dependent Anion Channel-1 (VDAC-1) Contributes to ATP Release and Cell Volume Regulation in Murine Cells
Creators: name: Okada, Seiko F.
name: Huang, Pingbo
name: Nicholas, Robert A.
name: Lazarowski, Eduardo R.
name: O'Neal, Wanda K.
name: Boucher, Richard C.
name: Craigen, William J.
name: Ostrowski, Lawrence E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Extracellular ATP regulates several elements of the mucus clearance process important for pulmonary host defense. However, the mechanisms mediating ATP release onto airway surfaces remain unknown. Mitochondrial voltage-dependent anion channels (mt-VDACs) translocate a variety of metabolites, including ATP and ADP, across the mitochondrial outer membrane, and a plasmalemmal splice variant (pl-VDAC-1) has been proposed to mediate ATP translocation across the plasma membrane. We tested the involvement of VDAC-1 in ATP release in a series of studies in murine cells. First, the full-length coding sequence was cloned from a mouse airway epithelial cell line (MTE7b − ) and transfected into NIH 3T3 cells, and pl-VDAC-1-transfected cells exhibited higher rates of ATP release in response to medium change compared with mock-transfected cells. Second, ATP release was compared in cells isolated from VDAC-1 knockout [VDAC-1 (−/−)] and wild-type (WT) mice. Fibroblasts from VDAC-1 (−/−) mice released less ATP than WT mice in response to a medium change. Well-differentiated cultures from nasal and tracheal epithelia of VDAC-1 (−/−) mice exhibited less ATP release in response to luminal hypotonic challenge than WT mice. Confocal microscopy studies revealed that cell volume acutely increased in airway epithelia from both VDAC-1 (−/−) and WT mice after luminal hypotonic challenge, but VDAC-1 (−/−) cells exhibited a slower regulatory volume decrease (RVD) than WT cells. Addition of ATP or apyrase to the luminal surface of VDAC-1 (−/−) or WT cultures with hypotonic challenge produced similar initial cell height responses and RVD kinetics in both cell types, suggesting that involvement of VDAC-1 in RVD is through ATP release. Taken together, these studies suggest that VDAC-1, directly or indirectly, contributes to ATP release from murine cells. However, the observation that VDAC-1 knockout cells released a significant amount of ATP suggests that other molecules also play a role in this function.
(1843) Daniel Richmond
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
RESEARCH ON THE BENTHIC POPULATION OF THE HARD SUBSTRATE OF THE PORT OF ISCHIA - INFRACOASTAL PHOTOFIL - POLYCHAETES .2
Creators: name: Fresi, E.
name: Colognola, R.
name: Gambi, M. C.
name: Giangrande, A.
name: Scardi, M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1984

Abstract
Additional file 2 of How are nature based solutions contributing to priority societal challenges surrounding human well-being in the United Kingdom: a systematic map protocol
Creators: name: Dick, Jan
name: Miller, James D.
name: Carruthers-Jones, Jonathan
name: Dobel, Anne J.
name: Carver, Steve
name: Garbutt, Angus
name: Hester, Alison
name: Hails, Rosie
name: Magreehan, Victoria
name: Quinn, Melina
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Project details of other projects awarded by UKRI-NERC.
A Dramatically Growing Shear Rigidity Length Scale in a Supercooled Glass Former ($NiZr_2$)
Creators: name: Weingartner, Nicholas B.
name: Soklaski, Ryan
name: Kelton, K. F.
name: Nussinov, Zohar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Finding a suitably growing length scale that increases in tandem with the immense viscous slowdown of supercooled liquids is an open problem associated with the glass transition. Here, we define and demonstrate the existence of one such length scale which may be experimentally verifiable. This is the length scale over which external shear perturbations appreciably penetrate into a liquid as the glass transition is approached. We provide simulation based evidence of its existence, and its growth by at least an order of magnitude, by using molecular dynamics simulations of NiZr2, a good fragile glass former. On the probed timescale, upon approaching the glass transition temperature from above, this length scale, ξ is also shown to be consistent with Ising-like scaling. Furthermore, we demonstrate the possible scaling of ξ about the temperature at which super-Arrhenius growth of viscosity, and a marked growth of the penetration depth sets in. Our simulation results suggest that upon supercooling, marked initial increase of the shear penetration depth in fluids may occur in tandem with the breakdown of the Stokes-Einstein relation.
description: 10 pages, 12 figures;Renamed, Massive Revisions, PRB Accepted
MOESM1 of How are nature based solutions contributing to priority societal challenges surrounding human well-being in the United Kingdom: a systematic map protocol
Creators: name: Dick, Jan
name: Miller, James
name: Carruthers-Jones, Jonathan
name: Dobel, Anne
name: Carver, Steve
name: Garbutt, Angus
name: Hester, Alison
name: Hails, Rosie
name: Magreehan, Victoria
name: Quinn, Melina
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 1. Protocol to collect and report priority NBS actions and targeted human wellbeing outcomes.
Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia
Creators: name: Trout, Laura
name: Tarran, Robert
name: Donaldson, Scott H.
name: Boucher, Richard C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: A key aspect of the lung's innate defense system is the ability of the superficial epithelium to regulate airway surface liquid (ASL) volume to maintain a 7-μm periciliary liquid layer (PCL), which is required for cilia to beat and produce mucus flow. The mechanisms whereby airway epithelia regulate ASL height to ≥7 μm are poorly understood. Using bumetanide as an inhibitor of Cl − secretion, and nystatin as an activator of Na + absorption, we found that a coordinated “blending” of both Cl − secretion and Na + absorption must occur to effect ASL volume homeostasis. We then investigated how ASL volume status is regulated by the underlying epithelia. Cilia were not critical to this process as (a) ASL volume was normal in cultures from patients with primary ciliary dyskinesia with immotile cilia, and (b) in normal cultures that had not yet undergone ciliogenesis. However, we found that maneuvers that mimic deposition of excess ASL onto the proximal airways, which occurs during mucociliary clearance and after glandular secretion, acutely stimulated Na + absorption, suggesting that volume regulation was sensitive to changes in concentrations of soluble mediators in the ASL rather than alterations in ciliary beating. To investigate this hypothesis further, we added potential “soluble mediators” to the ASL. ASL volume regulation was sensitive to a channel-activating protein (CAP; trypsin) and a CAP inhibitor (aprotinin), which regulated Na + absorption via changes in epithelial Na + channel (ENaC) activity in both normal and cystic fibrosis cultures. ATP was also found to acutely regulate ASL volume by inducing secretion in normal and cystic fibrosis (CF) cultures, while its metabolite adenosine (ADO) evoked secretion in normal cultures but stimulated absorption in CF cultures. Interestingly, the amount of ASL/Cl − secretion elicited by ATP/ADO was influenced by the level of CAP-induced Na + absorption, suggesting that there are important interactions between the soluble regulators which finely tune ASL volume.
ENaC Proteolytic Regulation by Channel-activating Protease 2
Creators: name: Agustín, García Caballero
name: He, Hong
name: Stutts, M. Jackson
name: Dang, Yan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Epithelial sodium channels (ENaCs) perform diverse physiological roles by mediating Na + absorption across epithelial surfaces throughout the body. Excessive Na + absorption in kidney and colon elevates blood pressure and in the airways disrupts mucociliary clearance. Potential therapies for disorders of Na + absorption require better understanding of ENaC regulation. Recent work has established partial and selective proteolysis of ENaCs as an important means of channel activation. In particular, channel-activating transmembrane serine proteases (CAPs) and cognate inhibitors may be important in tissue-specific regulation of ENaCs. Although CAP2 (TMPRSS4) requires catalytic activity to activate ENaCs, there is not yet evidence of ENaC fragments produced by this serine protease and/or identification of the site(s) where CAP2 cleaves ENaCs. Here, we report that CAP2 cleaves at multiple sites in all three ENaC subunits, including cleavage at a conserved basic residue located in the vicinity of the degenerin site (α-K561, β-R503, and γ-R515). Sites in α-ENaC at K149/R164/K169/R177 and furin-consensus sites in α-ENaC (R205/R231) and γ-ENaC (R138) are responsible for ENaC fragments observed in oocytes coexpressing CAP2. However, the only one of these demonstrated cleavage events that is relevant for the channel activation by CAP2 takes place in γ-ENaC at position R138, the previously identified furin-consensus cleavage site. Replacement of arginine by alanine or glutamine (α,β,γR138A/Q) completely abolished both the Na + current (I Na ) and a 75-kD γ-ENaC fragment at the cell surface stimulated by CAP2. Replacement of γ-ENaC R138 with a conserved basic residue, lysine, preserved both the CAP2-induced I Na and the 75-kD γ-ENaC fragment. These data strongly support a model where CAP2 activates ENaCs by cleaving at R138 in γ-ENaC.
Investigation of additive manufactured Split P TPMS elastomeric structures for diabetic foot insoles
Creators: name: Claybrook, Fay
name: Mohammed, Mazher
name: Southee, Darren
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: We present preliminary work optimising 3D printed porous triply periodic minimal surface (TPMS) structures, formed using Thermoplastic Polyurethane (TPU) elastomer with Fused Filament Fabrication (FFF). We examine the compressive properties of a Split P TPMS structure for changes in the unit cell porosity for a fixed unit cell size of 10mm. Preliminary results highlight opportunities to apply Split P TPMS structures made in TPU to mimic properties of medical grade foams typically found in diabetic foot orthotics, and through porosity adjustment, can be tailored across a greater range of compressive strengths. Such structures may find usefulness in creating a new generation of diabetic foot insoles whereby the compressive strength can be tailored to the unique loading conditions of the user.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. 1 (2022): Trans. AMMM
First record of Albunea carabus (Linnaeus, 1758) (Decapoda: Anomura: Hippoidea) in the Aegean Sea
Creators: name: CORSINI-FOKA, Maria
name: KALOGIROU, Stefanos
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The sand crab Albunea carabus (Linnaeus, 1758) was collected for the first time in the Aegean waters. This finding contributes to fill a lack of knowledge on the geographical distribution of the species in the Eastern Mediterranean Sea and increases the number of the known Aegean decapod species to 282.
(1845) Joseph Fowler Arthur
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Food and biochemical composition of the spot-tail mantis shrimp Squilla mantis caught in three Tunisian Gulfs: Tunis, Hammamet and Gabes
Creators: name: MILI, Sami
name: BOURIGA, Nawzet
name: ENNOURI, Rym
name: JARBOUI, Othman
name: MISSAOUI, Hechmi
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The objectives of the present study were to characterize the feeding habits and the biochemical composition of the spot-tail mantis shrimp caught in Tunisian waters: Gulfs of Tunis, Hammamet and Gabes. The feeding habits and the biochemical composition were studied by examining the stomach contents and the muscle tissue of S. mantis. Seven different food categories were identified. Crustaceans were the most common prey in this Gulf; the most common were shrimp Penaeus kerathurus (12.39%), followed by Crabs. Fishes were the important prey in the Gulf of Tunis and Hammamet, of these; the most common were Mullus sp. (15.37%) and E. encrasicolus (11.24%). The species from the Gulf of Gabes showed higher levels of lipid and carbohydrate contents in october. Saturated fatty acids reached 41.96% in the Gulf of Gabes species and 35.35% in the Gulf of Hammamet in autumn. The n-3 polyunsaturated fatty acids content in Squilla mantis of the Gulf of Gabes was the higher. The n-3/n-6 index showed a significant level indicating a tendency to accumulate n-3 fatty acids in Squilla mantis of the Gulf of Gabes and Hammamet and n-6 fatty acids in the Gulf of Tunis. Total amino acid content ranged from 539.22 to 595.65 mg/g crude protein, in which, glutamic acid was the most abundant. The biochemical differences observed seem to be due to feeding habits, which may have a significant interspecific effect on food intake.
LA PONTE ET LE DÉVELOPPEMENT DE POLYMASTIA ROBUSTA (DÉMOSPONGES)
Creators: name: BOROJEVIC, Radovan
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: The morphology of the egg and the formation of the larva in Polymastia robusta Bowerbank are described. The larva is a flattened blastula, formed of equal and flagellated blastomeres; it lives on the bottom and glides actively on its flattened side. The metamorphosis and the differentiation of the cells are long delayed. The first differentiated cells are those of the basal and marginal epithelium.
การพัฒนากฎหมายประกันสังคมสำหรับแรงงานต่างด้าวซึ่งเข้ามาทำงานในประเทศไทยโดยชอบด้วยกฎหมาย
Creators: name: เรืองเดช นวสันติ
name: ณฐ สันตาสว่าง
name: ภูมิ โชคเหมาะ
name: ไพศิษฐ์ พิพัฒนกุล
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: ประกันสังคม
แรงงานต่างด้าว
พระราชบัญญัติประกันสังคม พ.ศ. 2533
Social Security
Foreign Workers
Social Security Act, B.E. 2533

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 514-528
MOESM4 of How are nature based solutions contributing to priority societal challenges surrounding human well-being in the United Kingdom: a systematic map protocol
Creators: name: Dick, Jan
name: Miller, James
name: Carruthers-Jones, Jonathan
name: Dobel, Anne
name: Carver, Steve
name: Garbutt, Angus
name: Hester, Alison
name: Hails, Rosie
name: Magreehan, Victoria
name: Quinn, Melina
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 4. Search string building process.
A non-assembly approach for an additively manufactured finger prothesis
Creators: name: Harden, Felix
name: Förster, Benjamin Guido
name: Damiani, Christian
name: Kral, Roland
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: A new approach to print non-assembly mechanisms with reduced joint clearance is used to create an additive manufactured finger prosthesis. Like other additive manufacturing methods, Fused Layer Modeling (FLM) requires a sufficient clearance between parts to archive moveable non-assembly mechanisms. A two-material design and a heat treatment allowed improving the accuracy of the movement beyond the printing limitations. It was shown that a functional finger prosthesis can be produced using this technique.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. 1 (2022): Trans. AMMM
แนวทางการพัฒนาองค์กรเพื่อเสริมสร้างขีดความสามารถด้านการแข่งขันขององค์กรโลจิสติกส์ขนาดกลางในเขตพัฒนาพิเศษภาคตะวันออก
Creators: name: ชานนท์ ทนงค์
name: นุจรี ภาคาสัตย์
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: ความสามารถทางการแข่งขัน
ความยั่งยืนขององค์กร
เขตพัฒนาพิเศษภาคตะวันออก
โลจิสติกส์
Competitive Advantage
Sustainability of the Organization
Eastern Economic Corridor
Logistics

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 529-541
Additional file 5 of How are nature based solutions contributing to priority societal challenges surrounding human well-being in the United Kingdom: a systematic map protocol
Creators: name: Dick, Jan
name: Miller, James D.
name: Carruthers-Jones, Jonathan
name: Dobel, Anne J.
name: Carver, Steve
name: Garbutt, Angus
name: Hester, Alison
name: Hails, Rosie
name: Magreehan, Victoria
name: Quinn, Melina
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 5. List of eligible studies identified for testing the search strategy.
Functionalization of 3D-printed tablets by atmospheric pressure plasma coating
Creators: name: Reus, Johanna
name: Hain, Kevin
name: Tidau, Marius
name: Finke, Jan Henrik
name: Lachmann, Kristina
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: One of the greatest challenges in the future design of pharmaceutical products is to guarantee the highest product qualities while at the same time flexibility in the production of pharmaceutics is demanded. Implementation of these requirements necessitates small batch sizes and also, in extreme cases, the production of one dosage form, e.g. one tablet for a patient to take at a defined time in order to meet their health needs as precisely as possible. The production of tablets using 3D printing from non-toxic thermoplastic polymers loaded with active ingredients is suitable for this purpose. Tablets are coated to adjust their properties, for example their release profiles. Traditionally, these coatings are produced using batch processes by applying wet coating to the tablets. Such processes are inherently uneconomical for the coating of just one tablet. To overcome this problem, gas-based coatings deposited by a so-called cold plasma can be used to perform dry chemical surface modifications and coatings. One application of plasma treatment is the incorporation of functional groups, such as carboxylic acids, on the surface of tablets. Conventional tablet coatings utilize the pH-dependent solubility of carboxylic acid to delay the drug release after the passage through the stomach. Plasma deposition can also be used to create a barrier layer which may enhance the stability of the drug. First experiments address the deposition of barrier layers based on plasma-polymerized hexamethyldisiloxane (HMDSO) on 3D-printed tablets to influence their release profile. 3D-printed tablets made from polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were investigated after coating. The analysis of the coating was performed by FTIR spectroscopy and water contact angle measurements. After exposing the coated tablets to 0.1 mol HCl, a more pronounced swelling was observed for the coated tablets based on HPMC than for the uncoated tablets. Furthermore, the spectral changes due to coating were retained after HCl exposition and subsequent drying, which hints at a resistance to gastric acids. These results are first indications that plasma treatment may potentially influence the drug release profile.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
3D metrological characterization of functionally graded porous beta-titanium cellular structures to reproduce the complex internal human bone architecture
Creators: name: Emanuelli, Lorena
name: Jam, Alireza
name: Du Plessis, Anton
name: Lora, Carlo
name: De Biasi, Raffaele
name: Benedetti, Matteo
name: Pellizzari, Massimo
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: The aim of this work is to evaluate the manufacturability of two functionally graded porose auxetic structures in a novel promising beta-Ti21S alloy by laser powder bed fusion (LPBF). The auxetic structure is selected thanks to the possibility to decrease Young's modulus by decreasing Poisson's ratio. The cell design parameters, namely the aspect ratio a / b and the angle q, affect the Poisson's ratio and the elastic modulus. Typical values of elastic modulus are in the range of 0.8 - 11 GPa and a yield stress between 7 to 280 MPa. Considering the humane bone, as an example the femur one, it is not characterized by a uniform porosity of the trabecular bone but rather by a variation depending on the position inside the bone. This is the reason of creating a functionally graded porous structure (FGPS) inside the auxetic structure. The two different auxetic unit cells selected in this work are characterized by an aspect ratio equal to 1.5 and angle q of 15 ° and 25 °, respectively. The porosity is obtained with three relative density, each one with three unit cells inside. In detail, auxetic FGPS with q equal to 15 ° is characterized by a relative density gradient of 0.34, 0.49, 0.66. Comparison between design and printed samples highlights an under sizing effect on strut thickness and pore size in both auxetic FGPSs due to deviations from ideal geometry that induce changes to the observed parameters as measured by CT imaging .
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
Muscle weakness in Ryr1 I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca 2+ ion permeation and release from the sarcoplasmic reticulum
Creators: name: Loy, Ryan E.
name: Dirksen, Robert T.
name: MacLennan, David H.
name: Meissner, Gerhard
name: Orynbayev, Murat
name: Melzer, Werner
name: Zvaritch, Elena
name: Apostol, Simona
name: Andronache, Zoita
name: Xu, Le
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The type 1 isoform of the ryanodine receptor (RYR1) is the Ca 2+ release channel of the sarcoplasmic reticulum (SR) that is activated during skeletal muscle excitation–contraction (EC) coupling. Mutations in the RYR1 gene cause several rare inherited skeletal muscle disorders, including malignant hyperthermia and central core disease (CCD). The human RYR1 I4898T mutation is one of the most common CCD mutations. To elucidate the mechanism by which RYR1 function is altered by this mutation, we characterized in vivo muscle strength, EC coupling, SR Ca 2+ content, and RYR1 Ca 2+ release channel function using adult heterozygous Ryr1 I4895T/+ knock-in mice (IT/+). Compared with age-matched wild-type (WT) mice, IT/+ mice exhibited significantly reduced upper body and grip strength. In spite of normal total SR Ca 2+ content, both electrically evoked and 4-chloro- m -cresol–induced Ca 2+ release were significantly reduced and slowed in single intact flexor digitorum brevis fibers isolated from 4–6-mo-old IT/+ mice. The sensitivity of the SR Ca 2+ release mechanism to activation was not enhanced in fibers of IT/+ mice. Single-channel measurements of purified recombinant channels incorporated in planar lipid bilayers revealed that Ca 2+ permeation was abolished for homotetrameric IT channels and significantly reduced for heterotetrameric WT:IT channels. Collectively, these findings indicate that in vivo muscle weakness observed in IT/+ knock-in mice arises from a reduction in the magnitude and rate of RYR1 Ca 2+ release during EC coupling that results from the mutation producing a dominant-negative suppression of RYR1 channel Ca 2+ ion permeation.
Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape
Creators: name: Kapustina, Maryna
name: Jacobson, Ken
name: Elston, Timothy C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A cyclic process of membrane-cortex compression and dilation generates a traveling wave of cortical actin density that in turn generates oscillations in cell morphology.Rapid changes in cellular morphology require a cell body that is highly flexible yet retains sufficient strength to maintain structural integrity. We present a mechanism that meets both of these requirements. We demonstrate that compression (folding) and subsequent dilation (unfolding) of the coupled plasma membrane–cortex layer generates rapid shape transformations in rounded cells. Two- and three-dimensional live-cell images showed that the cyclic process of membrane-cortex compression and dilation resulted in a traveling wave of cortical actin density. We also demonstrate that the membrane-cortex traveling wave led to amoeboid-like cell migration. The compression–dilation hypothesis offers a mechanism for large-scale cell shape transformations that is complementary to blebbing, where the plasma membrane detaches from the actin cortex and is initially unsupported when the bleb extends as a result of cytosolic pressure. Our findings provide insight into the mechanisms that drive the rapid morphological changes that occur in many physiological contexts, such as amoeboid migration and cytokinesis.
Anisotropic blood contactor module with immobilized enzyme to treat septic acute kidney injury
Creators: name: Hirschwald, Lukas Tobias
name: Hagemann, Franziska
name: Restrepo, Maria
name: Peric, Petar
name: Höhs, Tim
name: Tillmann, Märthe
name: Neuhaus, Florian
name: Linkhorst, John
name: Wessling, Matthias
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: Worldwide, more than 3 million people yearly suffer from severe acute kidney injury, which, combined with sepsis, leads to high mortality. Dialysis is the therapeutic approach to treat AKI and is, therefore, a clinically and economically significant indication for blood treatment procedures. In 2018, Pickkers et al. showed in a study involving 301 patients with septic AKI that repeated intravenous application of the enzyme alkaline phosphatase led to a significantly better survival rate for those affected than the administration of a placebo. However, studies with healthy volunteers show that the enzyme concentration in the blood drops to below 10 percent of the initial peak concentration only 4 hours after intravenous infusion. In this work, we immobilize the enzyme on a blood-accessible surface. As the enzyme is no longer freely available in the body, degradation is inhibited, a smaller amount of drug is required, and as tissues and organs are less exposed to the enzyme, side effects are reduced. Three geometrically distinct modules with identical fluid volume and internal surface area were fabricated from a hemocompatible material using digital light processing. The investigated internal module geometries are (a) straight tubes similar to a dialyzer (tube module), (b) isotropic triply periodic minimal surface structures (iTPMS module), and (c) anisotropic TPMS structures (aTPMS module). The convoluted TPMS structure provides an optimal, continuous surface geometry for blood without sharp edges and corners, thus reducing hemolysis and coagulation. In comparison to the tube module, the iTPMS and aTPMS modules are expected to significantly improve the enzymatic conversion of toxins in the blood due to intrinsic mixing induced by the TPMS structure.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
ความตั้งใจซื้อและบุพปัจจัยที่มีผลต่อการซื้อสินค้าออนไลน์ของผู้บริโภคกลุ่ม Silver Generation ในเขตกรุงเทพมหานคร
Creators: name: ประพันธ์ วงศ์บางโพ
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: ความตั้งใจซื้อ
การซื้อสินค้าออนไลน์
ผู้บริโภคกลุ่ม Silver Generation
Buying Intention
Online Shopping
Silver Generation Consumers

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 542-556
Thermodynamics of quantum systems under dynamical control
Creators: name: Gelbwaser-Klimovsky, D.
name: Niedenzu, Wolfgang
name: Kurizki, Gershon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this review the debated rapport between thermodynamics and quantum mechanics is addressed in the framework of the theory of periodically-driven/controlled quantum-thermodynamic machines. The basic model studied here is that of a two-level system (TLS), whose energy is periodically modulated while the system is coupled to thermal baths. When the modulation interval is short compared to the bath memory time, the system-bath correlations are affected, thereby causing cooling or heating of the TLS, depending on the interval. In steady state, a periodically-modulated TLS coupled to two distinct baths constitutes the simplest quantum heat machine (QHM) that may operate as either an engine or a refrigerator, depending on the modulation rate. We find their efficiency and power-output bounds and the conditions for attaining these bounds. An extension of this model to multilevel systems shows that the QHM power output can be boosted by the multilevel degeneracy. These results are used to scrutinize basic thermodynamic principles: (i) Externally-driven/modulated QHMs may attain the Carnot efficiency bound, but when the driving is done by a quantum device ("piston"), the efficiency strongly depends on its initial quantum state. Such dependence has been unknown thus far. (ii) The refrigeration rate effected by QHMs does not vanish as the temperature approaches absolute zero for certain quantized baths, e.g., magnons, thous challenging Nernst's unattainability principle. (iii) System-bath correlations allow more work extraction under periodic control than that expected from the Szilard-Landauer principle, provided the period is in the non-Markovian domain. Thus, dynamically-controlled QHMs may benefit from hitherto unexploited thermodynamic resources.
N-Linked glycans on dengue viruses grown in mammalian and insect cells
Creators: name: de Silva, Aravinda M.
name: Hacker, Kari
name: White, Laura
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: This study compared the ability of mosquito and mammalian cell-derived dengue virus (DENV) to infect human dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN)-expressing cells and characterized the structure of envelope (E) protein N-linked glycans on DENV derived from the two cell types. DENVs derived from both cell types were equally effective at infecting DC-SIGN-expressing human monocytes and dendritic cells. The N-linked glycans on mosquito cell-derived virus were a mix of high-mannose and paucimannose glycans. In virus derived from mammalian cells, the N-linked glycans were a mix of high-mannose and complex glycans. These results indicate that N-linked glycans are incompletely processed during DENV egress from cells, resulting in high-mannose glycans on viruses derived from both cell types. Studies with full-length and truncated E protein demonstrated that incomplete processing was most likely a result of the poor accessibility of glycans on the membrane-anchored protein.
MOESM2 of How are nature based solutions contributing to priority societal challenges surrounding human well-being in the United Kingdom: a systematic map protocol
Creators: name: Dick, Jan
name: Miller, James
name: Carruthers-Jones, Jonathan
name: Dobel, Anne
name: Carver, Steve
name: Garbutt, Angus
name: Hester, Alison
name: Hails, Rosie
name: Magreehan, Victoria
name: Quinn, Melina
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 2. Project details of other projects awarded by UKRI-NERC.
การพัฒนามาตรการทางกฎหมายเกี่ยวกับธุรกิจรักษาความปลอดภัย
Creators: name: ชิษณุพงศ์ พรมมีเดช
name: สุขสมัย สุทธิบดี
name: อุทัย อาทิเวช
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: ธุรกิจรักษาความปลอดภัย
แรงงานข้ามชาติ
พนักงานรักษาความปลอดภัย
พระราชบัญญัติรักษาความปลอดภัย พ.ศ. 2558
Security Business
Migrant Workers
Security Guard
Security Act, B.E. 2558

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 557-570
Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection
Creators: name: Karasneh, Ghadah
name: Valyi-Nagy, Tibor
name: Bacsa, Sarolta
name: Shukla, Deepak
name: Liu, Jian
name: Dosa, Sandor
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Herpes simplex virus type 1 (HSV-1) is an important human pathogen and a leading cause of infectious blindness in the developed world. HSV-1 exploits heparan sulfate proteoglycans (HSPG) for attachment to cells. While the significance of heparan sulphate (HS) moieties in HSV-1 infection is well established, the role of specific proteoglycan core proteins in the infection process remains poorly understood. The objective of this study was to assess the roles of syndecan-1 and syndecan-2 core proteins in HSV-1 infection, both of which are expressed by many HSV-1 target cell types. Our results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival. Furthermore, HSV-1 infection increases syndecan-1 and syndecan-2 protein synthesis and a resultant increase in cell surface expression of HS. Our observations suggest that changes in syndecan-1 and syndecan-2 expression levels may be related to active viral infection. Taken together, our findings provide new insights into HSPG functions during HSV-1 entry and spread.
(1839) John Miller senior
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection
Creators: name: Matsushima, Glenn K.
name: Johnston, Robert E.
name: Schäfer, Alexandra
name: Brooke, Christopher B.
name: White, Laura J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne RNA virus of the genus Alphavirus, family Togaviridae, that is responsible for sporadic outbreaks in human and equid populations in Central and South America. In order to ascertain the role that complement plays in resolving VEEV-induced disease, complement-deficient C3−/− mice were infected with a VEEV mutant (V3533) that caused mild, transient disease in immunocompetent mice. In the absence of a functional complement system, peripheral inoculation with V3533 induced much more severe encephalitis. This enhanced pathology was associated with a delay in clearance of infectious virus from the serum and more rapid invasion of the central nervous system in C3−/− mice. If V3533 was inoculated directly into the brain, however, disease outcome in C3−/− and wild-type mice was identical. These findings indicate that complement-dependent enhancement of peripheral virus clearance is critical for protecting against the development of severe VEEV-induced encephalitis.
Centrifugal instability of Stokes layers in crossflow: the case of a forced cylinder wake
Creators: name: D'Adamo, Juan
name: Godoy-Diana, Ramiro
name: Wesfreid, José Eduardo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The wake flow around a circular cylinder at $Re\approx100$ performing rotatory oscillations has been thoroughly discussed in the literature, mostly focusing on the modifications to the natural Bénard-von Kármán vortex street that result from the forced shedding modes locked to the rotatory oscillation frequency. The usual experimental and theoretical frameworks at these Reynolds numbers are quasi-two-dimensional, since the secondary instabilities bringing a three-dimensional structure to the cylinder wake flow occur only at higher Reynolds numbers. In the present paper we show that a three-dimensional structure can appear below the usual three-dimensionalization threshold, when forcing with frequencies lower than the natural vortex shedding frequency, at high amplitudes, as a result of a previously unreported mechanism: a pulsed centrifugal instability of the oscillating Stokes layer at the wall of the cylinder. The present numerical investigation lets us in this way propose a physical explanation for the turbulence-like features reported in the recent experimental study of D'Adamo et al. (2011).
description: 18 pages, 13 figures. To appear in Proc. Roy. Soc. A. For supplementary video material, see http://vimeo.com/123152022
NOTES ON TREMOGASTERINA CANU AND TREMOGASTERINA ROBUSTA (HINCKS) (POLYZOA, ASCOPHORA)
Creators: name: POWELL, N.A.
name: P.L, Cook
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: This study was principally supported by a research grant awarded to the senior author by Haile Sellassie I University, Ethiopia. We should also like to thank Ato Wolde-Aregaye Redda, Director of Fisheries, Addis Ababa, who kindly made available to us the facilities of the Fisheries Department at Port Massawa. Examination of types pecimens was made possible to the junior author by the kindness of Dr. A. Andersson of the Naturhistoriska Riksmuseet, Stockholm, and by Dr. R. Boardman, of the Smithsonian Institution, Washington. Thephotographs were taken by the senior author and by Mr. P. Green (British Museum, Natural History), see Plate I for details.
Induction of MHC Class I Expression on Immature Thymocytes in HIV-1-Infected SCID-hu Thy/Liv Mice: Evidence of Indirect Mechanisms
Creators: name: McCune, Joseph
name: Lee, Robert
name: Bonyhadi, Mark
name: Su, Lishan
name: Wang, Liping
name: Kovalev, Grigoriy
name: Duus, Karen
name: Ho, David
name: Kaneshima, Hideto
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The SCID-hu Thy/Liv mouse and human fetal thymic organ culture (HF-TOC) models have been used to explore the pathophysiologic mechanisms of HIV-1 infection in the thymus. We report here that HIV-1 infection of the SCID-hu Thy/Liv mouse leads to the induction of MHC class I (MHCI) expression on CD4+CD8+ (DP) thymocytes, which normally express low levels of MHCI. Induction of MHCI on DP thymocytes in HIV-1-infected Thy/Liv organs precedes their depletion and correlates with the pathogenic activity of the HIV-1 isolates. Both MHCI protein and mRNA are induced in thymocytes from HIV-1-infected Thy/Liv organs, indicating induction of MHCI gene expression. Indirect mechanisms are involved, because only a fraction (<10%) of the DP thymocytes were directly infected by HIV-1, although the majority of DP thymocytes are induced to express high levels of MHCI. We further demonstrate that IL-10 is induced in HIV-1-infected thymus organs. Similar HIV-1-mediated induction of MHCI expression was observed in HF-TOC assays. Exogenous IL-10 in HF-TOC induces MHCI expression on DP thymocytes. Therefore, HIV-1 infection of the thymus organ leads to induction of MHCI expression on immature thymocytes via indirect mechanisms involving IL-10. Overexpression of MHCI on DP thymocytes can interfere with thymocyte maturation and may contribute to HIV-1-induced thymocyte depletion.
(1841) ? MacGowan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Modulation of HIV-1 Replication by a Novel RhoA Effector Activity
Creators: name: Zhang, Hangchun
name: Wang, Liping
name: Hart, Matthew J.
name: Solski, Patricia A.
name: Su, Lishan
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The RhoA GTPase is involved in regulating actin cytoskeletal organization, gene expression, cell proliferation, and survival. We report here that p115-RhoGEF, a specific guanine nucleotide exchange factor (GEF) and activator of RhoA, modulates HIV-1 replication. Ectopic expression of p115-RhoGEF or Gα13, which activates p115-RhoGEF activity, leads to inhibition of HIV-1 replication. RhoA activation is required and the inhibition affects HIV-1 gene expression. The RhoA effector activity in inhibiting HIV-1 replication is genetically separable from its activities in transformation of NIH3T3 cells, activation of serum response factor, and actin stress fiber formation. These findings reveal that the RhoA signal transduction pathway regulates HIV-1 replication and suggest that RhoA inhibits HIV-1 replication via a novel effector activity.