cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Intranasal esketamine in treatment resistant depression – a double-blind, randomized, efficacy and dose response study
Creators: name: Daly, Ella
name: Jaskaran B. Singh
name: Fedgchin, Maggie
name: Cooper, Kimberly
name: Lim, Pilar
name: Melman, Caroline
name: Husseini Manji
name: Nueten, Luc Van
name: Shelton, Richard C.
name: Thase, Michael E.
name: Ahmad, Maha
name: Bruecker, Geert De
name: Drevets, Wayne C.
Publisher: name: F1000Research
Year: 2016

description: Background: Intravenous ketamine and esketamine (ESK) produce rapid antidepressant action in treatment-resistant depression (TRD) patients, however dose response is not known. Study assessed efficacy, dose response and safety of intranasal ESK and ability to sustain response with gradual tapering of treatment frequency.

Methods: In the Panel A (conducted in USA and Belgium) of this placebo-controlled, double-blind study (Panel B: ongoing in Japan and not presented here), patients received study medication in two 1-week periods (Period 1: randomization [3:1:1:1] to placebo, ESK 28mg, 56mg, or 84mg [twice-weekly]; Period 2: non-responding placebo patients [moderate-to-severe symptoms] re-randomized [1:1:1:1] to one of above 4 treatments). After DB phase, patients entered 9-week optional open-label (OL) phase with tapered treatment frequency and 8-week posttreatment follow-up. Primary efficacy endpoint: change from baseline to day 8 (each period) in Montgomery-Asberg Depression Rating Scale (MADRS) total score (ANCOVA).

Results: Mean change in MADRS total score (DB phase, both periods combined; weighted combination test) in all 3 ESK groups was superior to placebo (ESK 28mg: p=0.021, 56mg: p=0.001, 84mg: p<0.001). 57 of 67 patients from DB phase entered OL phase. No new safety findings were noted.

Conclusions: All 3 doses of intranasal ESK were efficacious in TRD treatment; however, 28mg dose had less durable effect. There was evidence suggesting sustained response after cessation of OL dosing. All 3 doses were well-tolerated.
Assessment of algorithms for identifying patients with triple-class refractory multiple myeloma using real-world data
Creators: name: Sinyavskaya, Liliya
name: Meche, Aster
name: Faucher, Ariane
name: Hlavacek, Patrick
name: Johnson, Sarasa MA
name: DiBonaventura, Marco
name: Vekeman, Francis
name: Ren, Jinma
name: Schepart, Alex
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Objective: Patients with triple-class refractory (TCR) multiple myeloma (MM) have limited treatment options and poor prognoses. This high unmet need has prompted the development of new therapies allowing for improved outcomes for these patients. Recently, new targeted therapies for the treatment of patients with relapsed or refractory MM have been approved based on single-arm clinical trial results. Real-world (RW) data enable a better understanding of the effectiveness of new therapies in clinical practice and provide external controls for single-arm studies. However, using RW data to identify patients with TCR MM is challenging and subject to limitations. Methods: In this retrospective cohort study of an analysis of the COTA electronic health record (EHR) database, we used four algorithms to define refractory status and created four groups of patients with TCR MM initiating post-TCR therapy. Each algorithm relied on slightly different criteria to identify TCR patients, but all were based on the International Myeloma Working Group (IMWG)-derived and/or healthcare provider (HCP)-reported progressions within the database. Results: A total of 3815 patients with newly diagnosed MM met the eligibility criteria for this study. The choice of the algorithm did not impact the characteristics of identified patients with TCR MM (Algorithm 1 [n = 404], Algorithm 2 [n = 123], Algorithm 3 [n = 404], and Algorithm 4 [n = 375]), including their demographic and disease characteristics, MM treatment history, or treatment patterns received after becoming TCR. However, identifying TCR MM using a combination of IMWG-derived and HCP-reported progressions allowed up to a 70% increase in the size of the identified group of patients compared with using only IMWG-derived progressions. Conclusion: In RW settings, progressions from both IMWG-derived data and physician reports may be used to identify patients with TCR MM.
On the analysis of saturated pressure to detect fatigue
Creators: name: Faundez-Zanuy, Marcos
name: Lopez-Xarbau, Josep
name: Diaz, Moises
name: Garnacho-Castaño, Manuel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: Machine Learning (cs.LG)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: This paper examines the saturation of pressure signals during various handwriting tasks, including drawings, cursive text, capital words text, and signature, under different levels of fatigue. Experimental results demonstrate a significant rise in the proportion of saturated samples following strenuous exercise in tasks performed without resting wrist. The analysis of saturation highlights significant differences when comparing the results to the baseline situation and strenuous fatigue.
description: 12 pages. arXiv admin note: substantial text overlap with arXiv:2203.14782
Supplementary document for Diffraction-optimized aperiodic Surface Structures for enhanced Current Density in Organic Solar Cells - 5952910.pdf
Creators: name: Merkel, Milena
name: Imbrock, Jorg
name: Denz, Cornelia
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Path length elongation
Impact of Finger Rings on the Presence of Bacteria on Healthcare Providers' Hands
Creators: name: Patel, Anish
Publisher: name: Georgia State University
Year: 2018

description: Despite some evidence that suggest that finger ring use is associated with higher bacterial colonization, healthcare providers continue to wear finger rings in a healthcare setting. The aim of this systematic review was to synthesize the evidence to date regarding whether finger ring use increases bacterial colonization of healthcare providers' hands. Articles that studied the association finger ring use with hand hygiene and bacterial colonization were searched using PubMed, Google Scholar, and Georgia State University's online library systems. The overall results of this review suggest that finger ring use does increase the bacterial colonization on the hands of HCPs but not with significant difference when compared to no finger ring use; therefore, further research needs to be conducted to decide whether finger rings should be used in a healthcare setting or not.
Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults
Creators: name: Alam, Aniqa
Publisher: name: Georgia State University
Year: 2018

description: Cardiovascular disease (CVD) is the leading cause of death in the United States. Medical practitioners and public health officials alike consider atherosclerosis, in which plaque buildup leads to the hardening of arteries, to be one of the main culprits in CVD morbidity and mortality. Measuring low-density lipoprotein cholesterol (LDL-C) has been touted as an effective proxy for assessing the risk for atherosclerosis. However, new emerging evidence show that traditional lipid biomarkers, such as LDL-C, may not be as robust in CVD prediction as previously thought. Apolipoproteins, which are involved in the creation of lipoproteins, have been shown to be effective predictors of CVD events, even more so than LDL-C in some cases, but previous research have also established a non-linear trend with apolipoprotein B (ApoB) distribution when age is involved. Therefore, in light of past research, this study aims to examine potential differential associations between ApoB, LDL-C, and cardiovascular risk factors in the context of age groups. Using the 2013-2014 cycle of the National Health and Nutrition Examination Survey, we observed Spearman correlations and Wilcoxon/Kruskal-Wallis scores between various CVD risk factors (e.g.: body mass index, hypertension, diabetes status, etc.) and ApoB and LDL-C across two age cohorts. We found that ApoB has a special relationship with the younger cohort that does not manifest with LDL-C, and that this relationship attenuates in the older cohort. Based off of these results along with previous studies, assessment of CVD risk among the young would benefit from including ApoB in the already established battery of biomarkers.
Trustworthy by Design: The Viewer's Perspective on Trust in Data Visualization
Creators: name: McKinley, Oen
name: Pandey, Saugat
name: Ottley, Alvitta
Publisher: name: arXiv
Year: 2025
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Despite the importance of viewers' trust in data visualization, there is a lack of research on the viewers' own perspective on their trust. In addition, much of the research on trust remains relatively theoretical and inaccessible for designers. This work aims to address this gap by conducting a qualitative study to explore how viewers perceive different data visualizations and how their perceptions impact their trust. Three dominant themes emerged from the data. First, users appeared to be consistent, listing similar rationale for their trust across different stimuli. Second, there were diverse opinions about what factors were most important to trust perception and about why the factors matter. Third, despite this disagreement, there were important trends to the factors that users reported as impactful. Finally, we leverage these themes to give specific and actionable guidelines for visualization designers to make more trustworthy visualizations.
description: 17 pages, 4 figures, ACM CHI conference on Human Factors in Computing Systems
Association between Sleep Disturbances and Suicidal Ideation among Opioids Abusers
Creators: name: Patel, Aditiben
Publisher: name: Georgia State University
Year: 2018

description: INTRODUCTION: Several previous studies have documented a relationship between sleep problems and suicide. However, this association has not been explored specifically among opioid users. Given that studies have suggested that opioids can interrupt sleep and that opioid users are more likely to attempt suicide than non-users, it is important to further investigate the association between sleep disturbance and suicidal ideation, planning, and attempts among opioid abusers.
METHODS: Data from the National Survey on Drug Use and Health 2010-2014 survey were analyzed to assess whether there was an association between sleep problems and suicidal ideation, planning and attempts among individuals who report abusing opioid medications. Prevalence of opioids abusers by demographic characteristics, odds ratios and 95% confidence intervals unadjusted and adjusted by age, gender & mental health disorders were reported.
RESULTS: Results indicated that opioids abuse was higher in ages 18 to 25 years. Results of 2011 unadjusted and adjusted analyses showed significant associations between sleep disturbance and suicidal planning. Results of 2012 adjusted analyses showed significant associations between sleep disturbance and suicidal attempts. Results of 2013 unadjusted and adjusted analyses showed significant association between sleep disturbance and suicidal ideation among opioids abusers.
DISCUSSION: This research provided some evidence of an association between sleep disturbances and suicidal ideations, planning and attempts among opioids abusers using NSDUH data. This study’s findings can be beneficial for educational and public health prevention programs to promote a better understanding of sleep disturbance, suicidal ideation, planning, and attempts among opioid abusers. More research can help to find risk factors and achieve overall mission of harm reduction among opioids abusers.
Assessing the Effectiveness of an In-home Training Program for Parents of Children with Autism or Related Developmental Delays: A Multiple Baseline across Parent Skills
Creators: name: Williams, Robyn
Publisher: name: Georgia State University
Year: 2018

description: Autism spectrum disorders (ASD) are characterized by difficulty in communication and social interaction, and repetition of behaviors, requiring focused intervention efforts over time. Research has supported the role of parents as intervention agents in improving their children’s behavior, but relatively little of this research has been conducted in the home. This study examined the effectiveness of an in-home intervention of five two-hour sessions combining positive behavior supports (PBS) with the provision of visual supports (VS). The Positive Behavior Visual Support (PBVS) curriculum was developed by the Center for Leadership in Disability at Georgia State University and was previously implemented with both individual in-home and group delivery. In the present study, we wanted to examine more closely the session-by-session acquisition of parental skills using the PBVS curriculum. A single-subject multiple baseline design was used with one family, and partially replicated with a second, to document whether parent training on PBS increased the use of specific skills and whether that, in turn, had an effect on child problem behaviors. We hypothesized that the parents who participated in the PBVS study would increase their use of the positive behavior approaches, which would be accompanied by a decrease in one or more of their children’s targeted challenging behaviors. We looked at five positive behavior parenting skills, as well as child behaviors, during parent-child interaction sessions. We also predicted that parents would report a decrease in stress and an increase in knowledge and self-efficacy. One family withdrew from the study after three sessions so no follow-up was available. Results from the multiple baseline failed to support the predicted outcomes as both parent and child behaviors were quite variable from session to session. This family did demonstrate enhanced self-efficacy and parenting knowledge following the training. The brief time frame (only five sessions), paired with the relative long in-session time spent on parenting strategies (approximately 90 minutes per session), and that the data collection occurred in the first 15 minutes of the session (no time for warm-up or reminders) may have mitigated finding more specific session-by-session changes in behavior.
Risk factors for recurrence in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative early breast cancer in Japan: a systematic literature review and meta-analysis
Creators: name: Miyazaki, Naoki
name: Iwasaki, Toshiki
name: Sakai, Hitomi
name: Watanuki, Rurina
name: Tanizawa, Yoshinori
name: Cai, Zhihong
name: Kawaguchi, Tsutomu
name: Tsurutani, Junji
name: Nagashima, Kengo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The clinicopathological factors indicating risk of recurrence are used to guide the choice of perioperative therapy in patients with breast cancer. Although several risk factors for recurrence have been reported in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) early breast cancer in Japan, there has been no systematic review quantifying potential risk factors. We performed a systematic literature review and meta-analysis using the MEDLINE, Embase, Cochrane CENTRAL, and Japan Medical Abstract Society databases to identify risk factors for recurrence in HR+/HER2− early breast cancer in Japan. The primary outcome was relapse-free or disease-free survival (RFS/DFS), and the secondary outcomes were overall survival and breast cancer-specific survival (BCSS). Searches identified 42 eligible publications. Meta-analyses identified lymph node metastasis (hazard ratio: 2.76 [95% confidence interval: 1.97–3.88]), large tumor size (1.67 [1.24–2.23]), high histological grade (1.50 [1.04–2.16]), and high nuclear grade (2.02 [1.61–2.54]) as risk factors for RFS/DFS. Lymph node metastasis (2.43 [1.28–4.63]), large tumor size (1.80 [1.24–2.62]), and high histological grade (2.02 [1.44–2.84]) were also risk factors for overall survival, and high progesterone status was a possible favorable prognostic factor for BCSS (0.20 [0.10–0.42]). Identified risk factors were consistent with the previous reports, and this study provides quantitative summary of risk factors for HR+/HER2– early breast cancer recurrence in Japan. (PROSPERO Registration ID, CRD42022338391.)
Conectividad larval entre los sistemas arrecifales del Banco de Campeche: Identificación de sitios fuente y sumideros larvales
Creators: name: Simoes, Nuno
name: Hernández-Solis, Pablo Alberto
name: Mayorga-Adame, Claudia Gabriela
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Larva
subject: Larva/classification
subject: Plankton
subject: reef systems
subject: Reef
subject: Coral reef
subject: Coral Reefs
subject: arrecife
subject: Sea
subject: Fauna
subject: Marine fauna
subject: Dispersion
subject: Models, Biological
subject: biological models
subject: Biology
subject: Marine biology
subject: Biology/education
subject: Biology/trends
subject: Reproductive biology
subject: Developmental biology

description: Este cartel tuvo financiamiento de: HRI-LANRESC-KALANBIO A. C

Descubra más información sobre datos, investigaciones científicas, colecciones científicas y grupos de trabajo dedicados al estudio y conservación de la biodiversidad marina en https://www.bdmy.org.mx/

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Designed and illustrated by: naturae.art@gmail.com
The Impact of Violence Against Children On Human Capital in South Africa
Creators: name: Ugboke, Hope
Publisher: name: Georgia State University
Year: 2017

description: In this study, extensive data from the Cape Area Panel Study (CAPS) conducted between 2004-2009 was used to investigate the impact of violence against children on human capital within South Africa, through its impact on education and health of victims of physical and emotional abuse. The results of this study revealed a significant negative relationship between physical and emotional violence against children and their health and education, such that victims of either physical or emotional violence experienced increasingly poorer health and education levels, which lingered from childhood into adulthood. These results contribute pertinent knowledge to the existing body of work on the prevalence and consequences of violence against children and indicate significant adverse implications for South Africa's human capital due to the relationship between the human capital value and societal development. Therefore, this study proposes capacity building and awareness strategies, which can mitigate violence against children and ensure the health and well-being of children in the nation are protected.
A Cost Effectiveness Analysis of Breastfeeding Promotion Within Georgia's WIC Program
Creators: name: Wherry, Erica
Publisher: name: Georgia State University
Year: 2017

description: INTRODUCTION: It is well established that breastfeeding is optimal for infants for the first six months of life. Breastfeeding is a public health concern as current prevalence and initiation rates within the state of Georgia do not reflect public health target rates.
AIM: To examine the cost and health savings of infants who are exclusively breastfed versus the expenditures and health detriment for exclusively formula fed infants in Georgia.
METHODS: A cost effectiveness analysis was conducted on breastfeeding rates for infants in the Georgia’s WIC using data from the USDA.
RESULTS: Breastfeeding programming in GA is costlier than formula use for WIC infants, but more cost effective as a whole given short-term outcomes.
DISCUSSION: Improving breastfeeding rates in Georgia by providing infants the healthiest start in life is an adequate prevention strategy to reduce health disparities gaps within the United States.
fMRI correlates of action selection in adolescents with obsessive-compulsive disorder
Creators: name: Perkes, Iain
name: Quail, Stephanie L.
name: Morris, Richard W.
name: Hazell, Philip L.
name: Balleine, Bernard W.
Publisher: name: F1000Research
Year: 2016

description: Background: Aberrant action selection is the sine qua non of OCD; recent evidence reports impaired action selection in adults but little is known about adolescents with OCD. Neuroanatomical area required for outcome evaluation and integration. The present study explores the capacity of adolescents with OCD to integrate predictive and instrumental learning to select actions.

Participants were adolescents with OCD (n = 20) and healthy adolescents (n = 20) matched for age, gender, and handedness. Diagnostic interviews (K-SADS) and symptom measures (CY-BOCS) were undertaken. Participants learned to earn (instrumental) snacks from a virtual vending machine. They also learned about the relationship between predictive (Pavlovian) stimuli and food delivery. BOLD fMRI data were analysed using region of interest analysis within a limbic-OFC circuit and a caudate-PFC circuit.

Results: Cases and control groups were able to learn both the instrumental actions required to obtain outcomes and the predictive associations. The adolescents with OCD were unable to integrate these sources of information to guide action selection; there was a strong relationship with symptom measures. Further also presented.

Conclusions: This novel assessment of action selection in predictive cues to select actions, suggestive of altered cognitive control of goal-directed action.
Stable left PCC to right DLPFC hyperconnectivity in remitted depressed young adults
Creators: name: Bessette, Katie
name: Jenkins, Lisanne
name: Barba, Alyssa
name: Jacobs, Rachel
name: Skerrett, Kristy
name: Langenecker, Scott
Publisher: name: F1000Research
Year: 2016

description: Objective: Aberrant hyperconnectivity of the default mode network (DMN) during the resting state is a putative biomarker of major depressive disorder in the active state. Recently, this hyperconnectivity has also been observed in the remitted state (rMDD). This study examined seed-based connectivity patterns over two scan periods to examine the reliability of DMN hyperconnectivity in rMDD.

Methods: Seventy young adults (23 = HC, 47 = rMDD), ages 18-23, completed two resting state scans between 4 and 12 weeks apart. Left and right posterior cingulate cortex (PCC; +/- 5, 50, 36) seeds were used to probe connectivity of the DMN. Significant clusters (Alpha Sim corr p < .005, k > 55) were identified within a group by time MANCOVA, controlling for sex, to test stability of group differences over time.

Results: Hyperconnectivity between the left PCC and the right precuneus and the right dorsolateral prefrontal cortex (DLPFC) in rMDD compared to HC showed moderate test-retest stability over several weeks (r = 0.613, 0.620, respectively, p < .005). Of note, group connectivity differences were significant at both scan periods (p < .005). No clusters were significant from right PCC seed.

Conclusions: This is the first study to illustrate that connectivity of the PCC to the right precuneus and DLPFC is stable over time among young adults. Notably, hyperconnectivity of the PCC with the DLPFC, or DMN to Cognitive Control network (CCN), is a stable marker of the remitted phase of depression.
Extemporaneous combination therapy with nebivolol/amlodipine for the treatment of hypertension: a real-world evidence study in Europe
Creators: name: Desideri, Giovambattista
name: Cipelli, Riccardo
name: Pegoraro, Valeria
name: Ripellino, Claudio
name: Miroddi, Marco
name: Meto, Suada
name: Gori, Mario
name: Fabrizzi, Paolo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The investigation of the real-world use of the extemporaneous combination of nebivolol and amlodipine (NA-EXC) in adult patients diagnosed with hypertension in Europe. Retrospective analysis of data extracted from seven databases of patient medical records and prescriptions from Italy, Germany, France, Hungary, and Poland, to determine the prevalence and incidence of NA-EXC use and to estimate the number of patients potentially eligible for a single-pill combination of the two antihypertensives. Secondary objectives included: the description of the population of NA-EXC users and the assessment of their adherence to treatment based on the proportion of days covered. The use of NA-EXC was found to be common in Europe and ranged between 2.9% to 9.9% of all patients identified in the databases with a prescription of nebivolol and/or amlodipine. The estimated numbers of patients potentially eligible in 2019 for a single-pill combination of nebivolol and amlodipine in Italy and Germany were, respectively, 178,133 and 113,240. Users of NA-EXC were mostly aged 70–79 years, had metabolic disorders and other comorbidities; >70% of them had received ≥2 concomitant medications before starting NA-EXC. Adherence to NA-EXC was defined as high only in 15.6% to 35% of patients. The extemporaneous combination of nebivolol and amlodipine is commonly prescribed in Europe, however adherence to the therapy is poor. The development of a single-pill combination of nebivolol and amlodipine may improve adherence by reducing the number of pills administered to patients and thus simplifying treatment regimens.
Cluster Analysis in Epidemiology: An Application to Diabetic Dyslipidemia
Creators: name: Adetokun, Adewole
Publisher: name: Georgia State University
Year: 2018

description: INTRODUCTION:  Cluster analysis is a rapidly growing area in biostatistics. Its application in epidemiology is inconsistent in terms of choice of methods. Often, reasons for application of a method are not stated in research articles where cluster analyses are performed. Dyslipidemia is an important factor in determining cardiovascular morbidity and mortality among subjects with diabetes. Although clinical classification (based on cardiovascular risk) is available to guide the treatment of diabetic dyslipidemia, whether lipid profiles of diabetics exist in clusters is not well-understood.
AIM: This study sought to determine: (a), whether lipid profiles of adults with diabetes occur in clusters; (b), how the clusters differ across different lipids; and (c), how applying different methods of cluster analysis affect the clusters generated on the lipid profiles.
METHODS: Two-step, K-means, and hierarchical clustering analysis were applied to NHANES 2005-2014 data of adults with diabetes to compare numbers of clusters across four blood lipids singularly and jointly. For ease of comparison, “single” cluster option (as opposed to the “range” option) was used in the hierarchical method and the number of clusters specified in the hierarchical and k means methods were chosen to match those generated by the two-step agglomerative tool.
RESULTS:  Using two-step approach, total cholesterol yielded two clusters (n=1328 and n=1000), HDL yielded three clusters (n=1072, 992 and 260), LDL yielded three clusters (n=964, 1071 and 293), triglyceride yielded three clusters (n=1160, 843 and 325) and all four combined lipids yielded three clusters (n=1083, 432 and 813). The corresponding values using hierarchical clustering for the two total cholesterol clusters were 1484 and 844, respectively; values for the three HDL clusters were 489, 1772 and 67, respectively; values for the three LDL clusters were 1111, 988 and 229, respectively; values for the three triglyceride clusters were 1761, 417 and 150; and values for the three clusters using all four combined lipids were 1400, 891 and 37, respectively. Using k means approach, the analogous cluster values using total cholesterol were 1554 and 774; for HDL were 95, 1468 and 765; for LDL were 1111, 943 and 274; for triglyceride were 1230, 808 and 290; and for all four combined lipids were 1092, 950 and 286. Good-of-fit analysis indicates that differences in size of cluster membership based on the clustering method is small.
DISCUSSION: Lipid profiles in adults with diabetes exist in clusters and vary in the size depending on clustering analysis methods. The clinical implications of these differences warrant further studies.
Examining the Association Between Perceptions of Racial Discrimination and Depressive Symptoms Among African Americans in Georgia
Creators: name: Bassey, Obioesio
Publisher: name: Georgia State University
Year: 2017

description: INTRODUCTION: Depression in the United States is a persistent but relatively understudied public health issue, especially among particularly burdened populations that suffer from comorbidities and additional conditions that may trigger or exacerbate the presence of depressive symptoms. Stress is a leading causes of many health defects and many recent theories concerning health disparities center around the differences in stress between different subpopulations contribute to health. Perceived discrimination is a unique stressor that has been linked to the observed wellness gap between races. Discrimination in the United States is often targeted towards African Americans and the effect that this unique stressor has on mental health illnesses such as depression is relatively unknown.
AIM: The goal of this study is to explore the effects of perceived discrimination on the presence and severity of depressive symptoms among African Americans in the state of Georgia using the Behavioral Risk Favors Surveillance Survey administered by the Center for Disease Control
METHODS: The sample of participants consisted of 609 African American residents of Georgia, all whom are at least 18 years of age. Each participant completed a telephone survey where they were inquired about both their experiences with perceived discrimination and questions from the PHQ-8 days which gauged their level of depressive symptoms. A bivariate analysis was utilized between reported discrimination in the workplace and depressive symptoms, then a similar analysis was conducted using discrimination while seeking healthcare. An adjusted model for the risk of depressive symptoms was then created at a 95% statistical significance level. All statistical methods were conducted using SAS 9.4.
RESULTS: Depressive symptoms were most prevalent among those in the 25-34 age group (20.8%; 12.2 – 29.4), those who graduated college or technical school (19.1%; 12.7 – 25.4), and those who reported some form of chronic disease (19.2%; 12.1 – 26.4). The odds ratio of perceived discrimination and depressive symptoms were lowest among those who reported being treated better than other races at work (0.123; CI: 0.038 to 0.407). Odds of depressive symptoms among those who reported being treated better than other races when seeing healthcare were insignificant.
DISCUSSION: The results of this study demonstrate that African Americans in Georgia who reported equal or better racial based treatment in the workplace had lower odds of reporting depressive symptoms
Stiefel filters
Creators: name: Bogatyrev, Andrei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: The best uniform rational approximation of the Sign function on two intervals separated by zero was explicitly found by E.I. Zolotarëv in 1877. The natural extension of this problem to three bands was solved by E.Stiefel in 1961. We indicate the solutions overlooked by the prominent geometer and study their properties.
description: 13 pages, 5 figures
Accelerated aging of the putamen in Major Depressive Disorder
Creators: name: Camacho, Maria
name: Sacchet, Matthew
name: Livermore, Emily
name: Ewart Thomas
name: Gotlib, Ian
Publisher: name: F1000Research
Year: 2016

description: Background: Growing evidence indicates that Major Depressive Disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. MDD has also been associated with abnormal function and structure of neural reward circuitry, particularly in the basal ganglia (BG).

Conclusions: These findings indicate that age-related decreases in volume in the putamen, but not in the nucleus accumbens, caudate, or pallidum, are accelerated in MDD. Thus, the putamen may contribute uniquely to the negative long-term effects of MDD and, therefore, may be a useful target for the treatment of this debilitating disorder.
Early Transmission Dynamics and Forecasts of the Yellow Fever Outbreak in Angola, 2015-16
Creators: name: Tran, Thinh
Publisher: name: Georgia State University
Year: 2017

description: Introduction. Yellow fever is an infectious disease endemic in Africa and South America, and it is a vaccine-preventable disease. The outbreak of yellow fever in Angola, 2015-2016 posed a risk to the global health. In the early phase of the outbreak, mathematical modeling can be a useful tool to predicting how the outbreak might spread and what factors affect the course of the outbreak so that health policy makers and health organizations can react effectively. In this project, two mathematical models, generalized-growth model and generalized Richard model, were applied retrospectively to predict the case rises in the early phase and to forecast the short-term trend of the outbreak.
Data and method. The data was extracted from the WHO weekly outbreak situation reports, for the period from Dec 04, 2015 until Sep 29, 2016. The analysis was focused on the data of 3 provinces including the capital Luanda, Huambo, and Benguela. The generalized-growth model (GGM) was applied for fitting the model into the early phase of the outbreak. GGM and the generalized Richards model (GRM) was applied for short-term forecasting the trend of the outbreak’s peak. Simulations to project the uncertainty of the epidemic trend was conducted with MATLAB R2017a (The Mathworks, Inc.).
Results. Fitting GGM to the data of 3 provinces shows the patterns of case rises in the early phase widely vary from above-constant to sub-exponentially growth. Short-term forecasting with GGM becomes less capable after the epidemic reach its peak. GRM is more advantageous for the forecasting period containing the epidemic peak. However, it can be less effective when the outbreak is partly controlled or there are some interventions on the epidemic transmission.
Conclusion. GGM and GRM can be the useful tool to characterize the dynamic growth of an infectious outbreak in the early phase and produce a short-term forecast of dynamic patterns that shape the guidance and action for the outbreak control and interventions.
Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns
Creators: name: Mon-Ju Wu
name: Benson Mwangi
name: Passos, Ives
name: Bauer, Isabelle
name: Bo, Cao
name: Frazier, Thomas
name: Giovana Zunta-Soares
name: Soares, Jair
Publisher: name: F1000Research
Year: 2016

description: Background: Bipolar disorder (BD) has a lifetime prevalence of 2.1% worldwide and reportedly highly heritable with approximately 85% of risk variance attributed to genetic factors. This highlights the need for biomarkers to identify BD patients and those vulnerable to BD with high precision. Here, we investigated the utility of CANTAB measurements in 1) differentiating patients from healthy controls (HCs) at an individual subject level in center A.  2) Findings were replicated in center B. 3) A vulnerability marker was identified and used in detecting at-risk individuals (siblings of patients).

Methods: 21 euthymic patients and 21 demographically matched HCs were recruited at the University of North Carolina (Center A) and CANTAB measurements acquired. A multivariate machine learning algorithm was ‘trained’ to distinguish patients from HCs at Center A.  This model was replicated at the University of Texas at Houston (Center B) with 15 patients and 16 demographically matched HCs. Lastly, the replicated model was used to identify 15 at-risk individuals. All subjects were assigned a probability (0 – healthy, 1 – BD).

Results: The Center A model reported 69% accuracy (76% specificity, 62% sensitivity, chi-square p=0.013) in distinguishing patients from HCs. The replication model reported 74% accuracy (73% specificity, 75% sensitivity, chi-square p=0.007) in Center B. Predicted probabilities of at-risk individuals were significantly different from HCs (p=0.021) but not between at-risk and patients (p=0.594). The most relevant CANTAB tasks in this model included: affective go/no-go and Cambridge gambling task.

Conclusions: Our study highlights the potential of utilizing CANTAB measurements as biomarkers of vulnerability.
Examining the Association Between Iron Deficiency and Hemoglobin A1c Among Females in The National Health And Nutrition Examination Survey, 2003–2008 Using Propensity Score Analysis
Creators: name: Bisrat, Helen
Publisher: name: Georgia State University
Year: 2018

description: INTRODUCTION: Hemoglobin A1C (A1C) is a common test used in the diagnosis of diabetes mellitus and for long-term glucose management. Within the literature, it has been shown that there may be association between iron deficiency (ID) and A1C. In this study, we analyzed observational data using propensity score analysis to further explore this association.
AIM: The aim of this study is to compare the association of A1C and ID among non-pregnant, non-diabetic women aged 12-49 without a history of chronic renal disease using various statistical methods to control for covariate imbalance.
METHODS: Data on 4,656 women obtained from the National health and Nutrition Examination Survey (NHANES) during the period 2003-2008 was used to compare four different statistical methods to examine the association between A1C and ID: unadjusted and adjusted multivariable logistic regression and two different propensity score analyses to impose covariate balance between those who were ID and not-ID.
RESULTS: The unadjusted crude odds ratio between ID and elevated A1C was 2.32 (95% CI: 1.75, 3.07); while the adjusted odds ratio was slightly attenuated [OR = 2.1 (95% CI: 1.55, 2.85)] after controlling for age, income, education level, race, BMI, smoking status, and 24-hour dietary recall of iron intake. Further adjustment for the propensity score in the logistic model yielded an odds ratio of 1.88 (95% CI: 1.41, 2.49) if the propensity score was treated as a linear variable and 1.92 (95% CI: 1.45, 2.55) if treated as a categorical variable using the quintiles propensity score.
DISCUSSION: This study confirms the presence of a statistically significant association between A1C and ID, and further suggests this may be a causal association. These findings may have implications for diabetes screening if ID causes shifts in A1C.
Preferences of healthcare providers in Switzerland for attributes of pediatric hexavalent vaccines: a discrete-choice experiment
Creators: name: Samant, Salome
name: Oberle, Susanne
name: Marcek, Tomas
name: Poulos, Christine
name: Chintakayala, Phani
name: Langevin, Edith
name: Petigara, Tanaz
name: Boeri, Marco
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: To understand the preferences of healthcare providers (HCPs) in Switzerland for pediatric hexavalent vaccine attributes. A discrete-choice experiment included a series of choices between 2 hypothetical pediatric hexavalent vaccines with varying attributes: device type (including preparation time and risk of dosage errors), proportion of infants seroprotected against Haemophilus influenzae type b (Hib) at 11–12 months (pre-booster), packaging size, years on the market, and the thermostability at room temperature. Odds ratios (ORs) and conditional relative attribute importance (CRAI) were calculated using random-parameters logit. HCPs (150 pediatricians and 40 nursing staff) in Switzerland were unlikely to choose a vaccine conferring 50% (OR 0.00; 95% CI 0.00–0.00) or 70% (OR 0.01; 95% CI 0.00–0.01) of infants with Hib seroprotection at 11-12 months (pre-booster) compared with a vaccine conferring 90% seroprotection. The odds of choosing a vaccine available on the market for more than 3 years were nearly 5 times the odds of choosing a vaccine available on the market for less than 1 year (OR 4.76; 95% CI 1.87–7.65). The odds of choosing a vaccine in a prefilled syringe were nearly 3 times the odds of choosing a reconstituted vaccine (OR 2.77; 95% CI 1.39–4.15), and the odds of choosing a vaccine with a smaller package size were nearly 2 times the odds of choosing a vaccine with larger package size (OR 1.89; 95% CI 1.23–2.55). HCPs were equally likely to choose vaccines that can stay at room temperature for 6 versus 3 days (OR 1.07; 95% CI 0.73–1.42). According to CRAI, the most important attribute was Hib seroprotection, followed by years on the market, device type, and packaging size. Hib seroprotection at 11–12 months was the most important hexavalent vaccine attribute to HCPs in this study.
Spatial Analysis of County Level Influenza Vaccination Coverage Estimates
Creators: name: Meador, Seth
Publisher: name: Georgia State University
Year: 2018

description: INTRODUCTION: The Centers for Disease Control and Prevention (CDC) reported 43.3% of adults (>18) received a flu vaccination in the 2016-17 season (FluVaxView, 2018). Despite long-standing recommendations and the enormous burden caused by the virus, vaccination coverage for flu is consistently low across seasons.

AIMS: This study examines influenza vaccination coverage among adults at the county level, in the contiguous United States (U.S.), to identify clusters of high and low coverage as well as assess access to care variables that could impact coverage levels.

METHODS: County level influenza vaccination coverage estimates from the 2014 Behavioral Risk Factor Surveillance System (BRFSS) were examined to identify statistically significant clusters using global (Moran’s I) and local (Local Indicators of Spatial Association (LISA)) spatial clustering tests in GeoDa 1.10. To examine spatial effects of area provider supply and population demand variables, regression analyses were performed in GeoDaSpace. Independent variables were obtained from the Area Health Resource File (AHRF) and the National Council for Prescription Drug Program (NCPDP).

RESULTS: The Moran’s I value comparing coverage estimates to the spatially lagged values was 0.48, indicating the coverage estimates are not spatially random. Five hundred sixty five counties were considered ‘High-High’, four hundred sixty three were ‘Low-Low’, and sixty seven had high coverage but were surrounded by counties with low coverage, designated as ‘High-Low’. ‘Low-High’ counties are defined as counties with low coverage surrounded by counties with high coverage. Forty counties were considered ‘Low-High’ in this analysis. The final regression model used a regime to stratify counties by states that expanded Medicaid under the Affordable Care Act and those that did not. Among counties in states that did not expand Medicaid, the variables per capita pharmacies, per capita clinics, and percent less than sixty five years with no health insurance had no statistically significant associations with the outcome. In counties that were part of the Medicaid expansion, only per capita pharmacies and per capita clinics were not significant.

DISCUSSION: Per capita health care providers were statistically significant and positively associated with influenza vaccination coverage in both regime models, but had a larger regression coefficient in the expanded Medicaid regime model.
Lifetime Risk of Atrial Fibrillation by Race and Socioeconomic Status: The Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: Mou, Liping
Publisher: name: Georgia State University
Year: 2018

description: Atrial fibrillation (AF) is a common cardiac arrhythmia, affecting 2.7-6.1 million people in the US. The lifetime risk of AF has been previously reported in whites, but not in African Americans. Lifetime risk of AF by socioeconomic status has not been investigated before. This study investigated the lifetime risk of AF in African Americans and in individuals with different socioeconomic status. The analysis included 15,343 whites and African Americans in the Atherosclerosis Risk in Communities (ARIC) study who were followed for an average of 21 years. For analysis, total family income was categorized as <$25,000, $25,000-$49,999, and ?$50,000, and education as < high school graduate, high school graduate, and at least some college. Incident AF was ascertained from study electrocardiograms, hospital discharge records, and death certificates. Lifetime risk of AF was estimated by a modified Kaplan-Meier method. 2760 AF cases were identified during follow-up. Lifetime risk of AF was 36% (95% CI: 32-38%) in white men, 30% (26-32%) in white women, 21% (13-24%) in African American men, and 22% (16-25%) in African American women. Regardless of race and sex, incidence rates of AF decreased from the lowest to highest categories of income and education. In contrast, lifetime risk of AF increased in individuals with higher income and education in most sex-race groups. Cumulative incidence of AF was lower in those with higher income and education compared to their low socioeconomic status counterparts through earlier life but was reversed after age 85. The study concluded that lifetime risk of AF in the ARIC cohort was approximately 33% among whites and 20% among African Americans. Socioeconomic status was inversely associated with cumulative incidence of AF before the last decades of life.
Supplementary document for Visible and near-infrared dual-band switchable metasurface-enabled edge imaging - 5953079.pdf
Creators: name: Chen, Guanghao
name: Zhou, Junxiao
name: Bopp, Steven
name: Zhao, Junxiang
name: Liu, Zhaowei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary infomation
soy camino/cuerpo de un agua múltiple que se camina a sí mismo
Creators: name: Salazar Patrón, Luis Fernando
name: Williford Ancona, Gerardo Jesús
Publisher: name: Asociación Reconocer
Year: 2021

description: Poema: Luis Fernando Salazar PatrónIlustraciones: Gerardo Jesús Williford Ancona

fantasía incoherente, vívida pero incoherente // corazón y tierra // coral y venas // tierra de donde nace todo lo nacidoy venas que corren a miEn el alba un coral se vuelve luz de luna,a la vista, un arrullo de miradas inconexas entran en sí,posando para instantes, pasando por extraños,somos el constante reencuentro del “somos”y que toda luz sea azuly en la sangre un pigmento vierta su ocaso,y al tiento, un arroyo me recorra en fragmentos vitrales de tí,sobre faisanes de seda, sobre-adorando ceniza,sombra y cariciasy en tus manos nacen líneas infinitasEn el/ella/elle cae noche y sube a prisa;líneas de colores que más vale besar,tallando en piel con cincel de brisa,un memorial de notas frutales.porque hoy, soy camino y caminante.
description: El archivo publicado son capturas de pantalla de una copia preservada en Internet Archive. Este documento .pdf no fue publicado así por la revista. Es posible que las imágenes no tengan la distribución original. La captura fue realizada el 7 de agosto de 2024.