REVIEW OF INTRAVENOUS PLATELET RICH PLASMA
Creators: name: Angampally, Keerti
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420312
subject: Implementation science and evaluation

description: IntroductionPlatelet-rich plasma (PRP) is a natural source of signaling molecules that activates platelets, releasing growth factors and cytokines that can affect inflammation, angiogenesis, stem cell migration, and cell proliferation. PRP was first used in the early 1940s and has since gained popularity in various fields, including orthopaedics, cardiovascular surgery, cosmetics, and urology. PRP treatment is a regenerative medicine that uses and boosts the natural growth factors in blood cells to restore damaged tissue and treat various disease conditions. A novel study by Drake et al. suggests that High Dose Light Activated PRP replicates the therapeutic benefits of traditional SVF therapy, allowing PRP to deliver benefits without the need for liposuction and at a significantly lower cost. PRP therapy has significant potential in treating challenging and chronic neurological disorders, as well as conditions affecting the central and peripheral nervous systems and spinal diseases.<br>Materials and MethodsPlatelet-rich plasma (PRP) therapy utilizes autologous blood cells from the patient. Initially, a blood sample is collected from the patient and subsequently subjected to centrifugation, a process that effectively segregates the blood into components. The platelet rich plasma is subsequently gathered into a syringe for administration to a damaged region of bone or soft tissue.Patients receive PRP via intravenous administration. Both websites drprpusa and new york centre for Innovative medicine used TruDose PRP for calculation of PRP dose.In a study by Karina K etal , aaPRP was prepared using a process that involved calciumactivation and light irradiation. This process was chosen for its efficacy and safety in activating platelets and releasing bioactive molecules.<br>ResultsIntravenous Platelet-Rich Plasma (PRP) therapy has shown promising results in improving neurocognition, memory, and handwriting in COVID-19 patients. Studies by Karina Karina et al. showed that severe patients' plasma IL-1β content dropped by 12.48 pg/mL after two PRP treatments, while critical patients' increased to 18.77 pg/mL. Additionally, three PRP treatments significantly improved patients' PaO2/FiO2 ratio from 71.33 to 144.97 mmHg. The New York Centre for Innovative Medicines also found that PRP therapy is particularly beneficial for neurological disorders and autoimmune ailments. No adverse events were observed in any of the 611 patients who received aaPRP therapy. A case study by Karina K illustrated successful management of chronic itching triggered by latex and dairy with IV aaPRP therapy, resulting in significant improvement and a healthy pregnancy outcome without complications. Additionally, a study by Shehadi JA et al. assessed safety and functional outcomes for patients with spinal cord injury who received combined autologous PRP and bone marrow aspirate concentrate.<br>DiscussionWhile prior research has examined the safety of PRP for localized administration, there is a gap in assessing the safety of intravenous PRP administration. Our review has synthesized findings from a range of studies investigating the use of intravenous PRP therapy across various pathological conditions. The literature indicates a growing interest in IV PRP as a potential therapeutic modality, with studies reporting promising outcomes in terms of safety, efficacy, and clinical benefits.<br>One of the key distinctions highlighted in our review is the difference between IV PRP administration and localized PRP injections. While localized injections are commonly used for musculoskeletal conditions and tissue injuries, IV PRP has been explored for a wider spectrum of systemic and neurological disorders. This broader application of IV PRP underscores its potential as a versatile treatment option.<br>The development of Platelet-Rich Plasma (PRP) kits has revolutionized regenerative medicine due to their closed, sterile systems that mitigate contamination risks. These kits allow for precise separation of blood components and customization of PRP compositions tailored to specific clinical needs, ensuring consistent and high-quality PRP production.<br>Drake compares Platelet-Rich Plasma (PRP) to Stromal Vascular Fraction (SVF) therapy, suggesting PRP's potential for superior therapeutic outcomes and cost-effectiveness due to its similar growth factors and cytokines profile. Highlighting PRP's efficacy in systemic and autoimmune diseases without invasive procedures, it advocates for High Dose Light .Activated PRP Therapy as a preferred choice among stem cell practitioners for its curative effects and broad applicability in treating debilitating conditions.<br>The study by karina k etal is limited by its preliminary nature, small sample size (7 COVID -19 patients), and focus solely on IL-1β levels with no control group.<br>The inclusion of Platelet-rich plasma (PRP) IV therapy in Beverly Hills Med Spa's treatment signifies a growing trend in using PRP for healing and regeneration. This advanced IV therapy, targets chronic pain and injuries non-surgically while also offering a Fountain of Youth Drip treatment for skin rejuvenation.<br>The study by Shehadi JA et al found that co-administering PRP and BMAC intrathecally or intravenously caused no serious side effects and might even have had some therapeutic advantages.Larger clinical studies are needed to further test this treatment method.<br>Exact mechanisms of action underlying IV PRP therapy remain to be fully elucidated, proposed mechanisms include its anti-inflammatory properties, promotion of tissue regeneration, and modulation of immune responses. IV PRP therapy can be expensive, and insurance coverage may not always be available, making it a potential financial burden for some patients.<br>PRP therapy represents a promising avenue for patients seeking effective treatment options. While it may involve some initial expenses, the potential benefits it offers outweigh the financial considerations for many. Moreover, since PRP utilizes the patient's own blood, it minimizes the risk of adverse reactions, ensuring a safer treatment experience. Despite challenges such as variations in protocols and limited long-term data, efforts to address these issues are underway, with the aim of optimizing treatment protocols and guidelines. Additionally, regional regulations may vary, but ensuring that PRP therapy is administered by qualified healthcare professionals in line with relevant guidelines enhances patient safety and treatment efficacy. Overall, PRP therapy holds immense potential in providing patients with innovative and personalized treatment solutions.