cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
La necesidad de la prueba y la carga de la prueba del examinador en el examen de registro marcario
Creators: name: Cardoso González, Sergio Raúl
Publisher: name: Universidad Externado de Colombia
Year: 2018
Subjects: subject: Prueba - Derecho - Colombia
subject: Derecho - Aspectos económicos
subject: Administración pública - Legislación
subject: Registro marcario
subject: Superintendencia de Industria y Comercio
subject: Actuación administrativa
subject: Derecho probatorio

description: El Manual de Marcas expedido por la Delegatura para la Propiedad Industrial de la Superintendencia de Industria y Comercio de Colombia consagra las instrucciones para el examen de registrabilidad a cargo de la entidad con el propósito de brindar a los usuarios uniformidad y confianza en las decisiones y prevenir la aplicación de criterios diferentes ante situaciones análogas, de tal forma que “las decisiones se tomen de una manera coherente y armónica, obedeciendo a claros principios legales y técnicos, y no a interpretaciones personales y aisladas de los funcionarios” (Superintendencia de Industria y Comercio, 2016). No obstante, las resoluciones expedidas por la Dirección de Signos Distintivos de la SIC no reflejan la coherencia y armonía pretendida porque parte fundamental del examen se realiza por cuenta propia del examinador sin respaldo demostrativo que soporte sus aseveraciones y conclusiones; esa misma conducta se aprecia en la segunda instancia correspondiente a la Delegatura para la Propiedad Industrial de la SIC e idéntica actitud adopta la Sección Primera del Consejo de Estado en la decisión de las demandas de nulidad y restablecimiento del derecho contra las resoluciones así expedidas. Este estado de cosas hace disfuncional la estructura del sistema de registro porque, ante decisiones carentes de objetividad y frecuentemente contradictorias, la organización jerárquica no ofrece un remedio institucional, debido a que las instancias de control administrativo y judicial no se detienen en el análisis ni prestan atención al estudio de tan delicado asunto y por tanto, omiten la corrección de los problemas de fundamentación fáctica del examen de registro marcario, abstención que promueve la continuidad de la conducta e impide retroalimentar y ajustar el sistema desde la jurisdicción hacia la administración.
El juez ordinario como juez de los derechos humanos : una propuesta para la reparación integral de perjuicios
Creators: name: Castellanos Carreño, David
Publisher: name: Universidad Externado de Colombia
Year: 2018
Subjects: subject: Derechos humanos - Legislación
subject: Derecho público - Aspectos jurídicos
subject: Poder legislativo - Estudios de caso
subject: Procesos ordinarios
subject: La justicia de familia
subject: La justicia civil
subject: Perjuicios
subject: Derechos subjetivos

description: La necesidad de valorar el efecto de la violación de un derecho y, especialmente, las consecuencias que esta valoración puede tener en la comunidad o “ciudadanía mundial”, si quiere verse en términos Kantianos1, nos llama a establecer canales de diálogo entre las autoridades nacionales e internacionales para la construcción de un lenguaje común que se oriente, primero, a lograr la protección de la persona en todas sus esferas y, segundo, a buscar la homogeneidad de los ordenamientos jurídicos, principalmente, en lo que tiene que ver con los derechos que se reconocen a los individuos y los deberes que se imponen a las autoridades públicas frente a la garantía de esos derechos, incluida la de reparar los daños causados con ocasión de los conflictos de naturaleza diversa, presentes en escenarios comunes de la vida en sociedad, como es el caso de las relaciones familiares y laborales. Esta necesidad de diálogo encuentra justificación en lo que parece ser una errónea separación entre el ejercicio de la función judicial ordinaria, de un lado, y los sistemas de protección de derechos humanos, del otro. Esta perspectiva del ordenamiento jurídico, en nuestro criterio, nos obliga a replantear la forma como las autoridades judiciales estatales conciben y sustancian los conflictos de su competencia, en el entendido que resulta imperioso que los mismos aborden los asuntos de su competencia garantizando la efectividad de los derechos de las partes y, de resultar necesario, adoptando las medidas que consideren apropiadas para el restablecimiento de sus derechos, en todo caso, superando la concepción tradicional según la cual el pago de una suma de dinero compensa cualquier tipo de perjuicio, sin distingo de su naturaleza o de las particularidades que puedan llegar a presentarse en cada caso en concreto.
MATHEMATICS: EVERYTHING ENCOMPASSED IN ONE KINGDOM
Creators: name: UBAT, JOEL T.
Publisher: name: BINAS PUBLISHING
Year: 2025
Subjects: MATHEMATICS: EVERYTHING ENCOMPASSED IN ONE KINGDOM

description: PACIFICUS: A Literary Magazine by Binas Publishing (Volume 1, Issue 1)

 

PACIFICUS is a literary magazine by Binas Publishing that celebrates the power of words through a diverse collection of poetry, short stories, essays, and creative works. With its inaugural issue, PACIFICUS Volume 1, Issue 1 sets the stage for a platform where writers and artists can share their voices, perspectives, and imagination.

 

This edition features compelling narratives, thought-provoking reflections, and artistic expressions that resonate with readers across different backgrounds. Whether exploring themes of identity, resilience, culture, or the human experience, PACIFICUS embodies the essence of storytelling that inspires and connects.

 

As a publication dedicated to fostering literary excellence, PACIFICUS aims to nurture emerging and established writers while enriching the literary landscape. Each issue aspires to be a testament to creativity, insight, and the enduring impact of literature.
title: Maestría en derecho con énfasis en derecho bancario y bursátil
title: Contextualización del banco central como prestamista de última instancia
titleType: AlternativeTitle
Creators: name: Chaúx Artunduaga, Juan Camilo
Publisher: name: Universidad Externado de Colombia
Year: 2018
Subjects: subject: Bancos - Casos de estudio
subject: Sistema bancario - Aspectos jurídicos
subject: Finanzas - Legislación
subject: Liquidez
subject: Mercado
subject: Finanzas
subject: Banco central

description: la función del banco central como prestamista de última instancia tuvo su origen en la teoría clásica, la cual fue originada y desarrollada en Reino Unido por los economistas Sir Francis Baring, Henry Thornton y Walter Bagehot como respuesta a un contexto de crisis económica y financiera en el viejo continente, lo cual tiene en sus episodios fundamentales en el caso Barring Brothers (Barings Bank) - Baring Brothers & Co., teniendo la respuesta más importante a esta situación en la obra literaria de Bagehot conocida como Lombard Street: “una descripción del mercado de dinero”. En el caso Baring Brothers & Co., el Banco de Inglaterra (institución de carácter privado) no realizó el rescate financiero sobre Baring Brothers, contradiciendo el concepto de Walter Bagehot en la teoría clásica, toda vez que, ante la negativa del banco inglés no se cumplió con los principios de Bagehot, pero sus consecuencias en la economía inglesa profundizaron la crisis, lo que hizo ciertos y verdaderos los postulados consagrados por los autores clásicos, respaldando de esta manera la fundamentación y seriedad de esta posición económica y financiera que a lo largo de los años extendió sus efectos y ha cobrado mayor relevancia, actualidad y vigencia durante la crisis financiera de 2007, en la cual se encuentra que similar a lo sucedido entre el Banco de Inglaterra con Baring Brothers en su momento, el Gobierno americano ha permitido la quiebra de Lehman Brothers Holdings Inc., agudizando la crisis con los efectos y consecuencias económicas conocidas en el mercado. Sin embargo, precisamente por los resultados de la anterior decisión, la teoría clásica de Bagehot y compañía, surge nuevamente en el panorama como medida para explicar y justificar la intervención del banco central como prestamista de última instancia, evitando de esta manera la quiebra de importantes y gigantescos bancos comerciales, contrarrestando así el contagio sistémico causado por el riesgo de liquidez, lo cual de hecho hubiese terminado por colapsar el sistema financiero. Empero, es necesario precisar que ese rescate financiero no se hizo de manera deliberada, sino que recurriendo una vez más a los clásicos se echó una mirada a los principios de Bagehot: aplicando altas tasas a los préstamos que se entregaron por el gobierno a los bancos comerciales rescatados, exigiéndoseles garantías sólidas y líquidas, para evitar así un incentivo perverso (permitiendo el actuar imprudente de los banqueros asumiendo posiciones riesgosas, con la fiel confianza que el gobierno ante una fallad el mercado los rescataría, lo conocido en la literatura financiera como “riesgo moral” (moral hazard).
title: New Optimization Based Methodology for Calculating Thermodynamic Equilibria and Quantifying Uncertainties
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: This dissertation presents a novel methodology for automatic calculation of thermodynamic equilibria and quantifying numerical uncertainty for arbitrary multicomponent materials systems using the CALPHAD method. The methodology is based on mathematical analysis of two different model formulations implemented using an efficient set-based framework, and then applying state-of-the-art nonlinear optimization algorithms to find thermodynamic equilibria and quantify uncertainty at the stage of Gibbs energy minimization. Unlike previously developed methods that rely on guessing material components present in the equilibria, the new methodology involves all the components of a material system in computations, and thus is more robust. The thesis establishes theoretical equivalence between the models and provides results on extensive numerical experiments that demonstrate the practical importance of the developed methodology.
El alcance de la responsabilidad de las sociedades administradoras de fondos de capital privado frente a la delegación
Creators: name: Martínez Parra, Edna Juliana
Publisher: name: Universidad Externado de Colombia
Year: 2018
Subjects: subject: Inversiones de capital - Aspectos jurídicos
subject: Compañias financieras comerciales - Estudios de caso
subject: Liquidez - Economía
subject: Fondos de Capital Privado
subject: Crédito público
subject: Inversión colectiva
subject: Regulación financiera

description: Con el presente escrito se busca determinar si a la luz de los estatutos especiales que rige la actividad financiera en Colombia, es posible que las sociedades administradoras de fondos de capital privado puedan delegar en el gestor profesional las decisiones de inversión, y de establecerse que es posible tal delegación indagar acerca del riesgo jurídico al cual se vería abocado el inversionista ante una inadecuada decisión de inversión por parte del gestor profesional, y por tanto analizar el régimen de responsabilidad que sería aplicable a este tipo de vehículos de inversión, en ese sentido brindarle la confianza suficiente al inversionista de que cuenta con las herramientas jurídicas necesarias de protección de su inversión en el ordenamiento jurídico Colombiano, y con ello, llegar a incentivar, o de lo contrario, desincentivar dichos vehículos de inversión, permitiendo así determinar si son estructuras que pueden tener éxito en el país, y en consecuencia cumplir con las finalidades por las cuales fueron introducidos. Los Fondos de Capital Privado en Colombia son una especie dentro de los hoy llamados Fondos de Inversión Colectiva, en tal virtud se considera necesaria para los fines del presente escrito, hacer una breve introducción respecto de la creación de estos vehículos de inversión en el país. Los Fondos de Inversión Colectiva fueron creados, según lo indica el Ministerio de Hacienda y Crédito Público (Dirección de Regulación Financiera, 2012-2013), como mecanismos a través de los cuales se canaliza el ahorro del público y facilitan financiar proyectos amplios y a largo plazo, constituyéndose en mecanismos que generan economías de escala, reduciendo costos de administración en beneficio de los clientes, y democratizan la propiedad accionaria de las empresas a menores costos.
Propuesta regulatoria frente al Asset Protection Trust como mecanismo de fuga de capitales en Colombia
Creators: name: Navas Casas, Carolina Paola
Publisher: name: Universidad Externado de Colombia
Year: 2018
Subjects: subject: Mercado de capitales - Legislación
subject: Inversiones - Estudios de caso
subject: Bancos - Aspectos jurídicos
subject: Fuga de capitales
subject: Trust
subject: Asset Protection Trust
subject: Fraude

description: La identificación de modalidades de fuga de capitales, es el primer paso para que los Estados adopten medidas jurídicas e institucionales eficaces de lucha contra la elusión y la evasión fiscal generada a través de salida de capitales a escenarios offshore. Este trabajo busca proponer mecanismos de control para el Asset Protection Trust en COLOMBIA, para evitar el direccionamiento de capitales hacia jurisdicciones offshore, teniendo en cuenta que es uno de los más utilizados para realizar fugas o drenajes de capital hacia paraísos fiscales, donde las cargas impositivas son muy bajas. Se espera como resultado de este documento la propuesta alternativas eficientes para conjurar cualquier acción elusiva, prácticas que contribuyen al deterioro financiero del país.
description: The identification of forms of capital flight is the first step for States to adopt effective legal and institutional measures to combat tax avoidance and evasion generated through capital outflows to offshore scenarios. This work seeks to propose control mechanisms for the Asset Protection Trusts in COLOMBIA, to avoid the directing of capitals towards offshore jurisdictions, taking into account that it is one of the most used for leaks or capital drains towards tax havens, where the charges taxes are very low. It is expected as a result of this document the proposal of efficient alternatives to conjure any elusive action, practices that contribute to the financial deterioration of the country.
RАQАMLI АNIMАTSIYАLARNING О'QUVCHILАRNI ЕKОLОGIK SАVОDXОNLIGIGА TА'SIRI
Creators: name: Sulаymоnоvа, Sаоdаt
Publisher: name: Zenodo
Year: 2024

description: Rаqаmli аnimаtsiyа murаkkаb еkоlоgik tushunchаlаrni qiziqаrli vа tushunаrli tаrzdа tаqdim еtish оrqаli о‘quvchilаrning еkоlоgik sаvоdxоnligini оshirishdа kuchli vоsitа sifаtidа pаydо bо‘ldi. Ushbu mаqоlа rаqаmli аnimаtsiyаning o’quvchilarni аtrоf-muhit muаmmоlаrini tushunishigа tа'sirini о'rgаnаdi, uning bаrqаrоrlik bilаn bоg'liq tаnqidiy fikrlаsh vа muаmmоlаrni hаl qilish kо'nikmаlаrini rivоjlаntirishgа qаndаy yоrdаm bеrishini о'rgаnаdi. Tаdqiqоt аtrоf-muhit sаvоdxоnligini оshirish uchun rаqаmli аnimаtsiyаdаn fоydаlаnishning аfzаlliklаrini tа'kidlаb, uning mаvhum g'оyаlаrni аniq vа о'zаrо bоg'lаshdаgi rоlini tа'kidlаydi. Vizuаl hikоyа qilishni intеrаktiv еlеmеntlаr bilаn birlаshtirgаn hоldа, rаqаmli аnimаtsiyа nаfаqаt o’quvchilаrning еkоlоgik muаmmоlаrdаn xаbаrdоrligini оshirаdi, bаlki ulаrni bаrqаrоr hаyоtgа hаrаkаt qilishgа undаydi.
title: Experimental Investigation of the Relationship Between Finite Element Modeling and Digital Image Correlation
Creators: name: Nmair, Nicole
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Digital Image Correlation
subject: Structural health monitoring
subject: Full field measurements
subject: Finite element model updating
subject: Finite element modeling

description: This thesis investigates the comparison between the behavior of a structure modeled in a finite element (FE) software to the behavior captured using Digital Image Correlation (DIC). This experiment opens the gateway to quicker and easier structural assessments of the nation’s infrastructure through the use of DIC, a research area that requires further investigation. Through experimental analysis, the ability of DIC to be used as a finite element calibration tool was tested. Comparisons were completed by analyzing and comparing the behavior of a fixed-fixed aluminum frame under varying static loads at the midspan of the beam. Two structural parameters were assessed in the comparative analysis including the structures response strain and deflection. Through the analysis of the deflection, an adequate comparison was concluded between DIC and the FE model, with average absolute differences in deflection between 0.004866 and 0.007075 inches. However, the structures strain response consisted of high error in the DIC strains resulting in unsuccessful comparisons between DIC and the FE model. These errors are predicted to have been caused by vibration in the system during loading, noise caused by high light reflectivity, construction error, and primarily, speckle pattern inadequacy. Since the deflection results were deemed feasible, Euler-Bernoulli theory was used to derive strain equations from DIC deflections, resulting in viable strain results for the structure. Overall, DIC’s ability to be used as a finite element model updating tool was confirmed yet requires further investigation into optimization methods for model parameter updating. Through this research, a better understanding of the limitations of the DIC was investigated, providing recommendations on the method of initial calibration between DIC and FE software.
АNIMАTSIYАLАNGАN О'QUV QURОLLАRI ОRQАLI ЕKОLОGIK TА'LIMDАGI TО'SIQLАRNI YЕNGIB О'TISH TЕHNОLОGIYАLАRINI RIVОJLАNTIRISH
Creators: name: Sulаymоnоvа, Sаоdаt
Publisher: name: Zenodo
Year: 2024

description: Еkоlоgik tа'limdаgi tо'siqlаrni bаrtаrаf еtishgа qаrаtilgаn tеxnоlоgiyаlаrning rivоjlаnishi аnimаtsiоn tа'lim vоsitаlаrining jоriy еtilishi bilаn sеzilаrli yutuqlаrgа еrishdi. Ushbu vоsitаlаr еkоlоgik tа'limdаgi umumiy muаmmоlаrgа, mаsаlаn, chеklаngаn ishtirоk, fоydаlаnish imkоniyаtining yо'qligi vа murаkkаb еkоlоgik tushunchаlаrni еtkаzishdаgi qiyinchiliklаrgа innоvаtsiоn еchimlаrni tаqdim еtаdi. Mаqоlа ushbu tо'siqlаrni bаrtаrаf еtishdа jоnlаntirilgаn tа'lim vоsitаlаrining rоlini о'rgаnаdi, ulаrning bаrqаrоr аmаliyоtgа bо'lgаn tаlаblаrini tushunish vа mоtivаtsiyаsini оshirishdаgi sаmаrаdоrligini tа'kidlаydi. Vizuаl hikоyа, intеrаktivlik vа mоslаshuvchаnlikni birlаshtirgаn hоldа, аnimаtsiоn vоsitаlаr еkоlоgik tа'lim lаndshаftini о'zgаrtirish, uni yаnаdа qiziqаrli, qаmrаb оluvchi vа tа'sirli qilish pоtеntsiаligа еgа.
Call to Action for Libraries: Improve the Discoverability of Open Textbooks. A Step-By-Step Guide.
Creators: name: Pianos, Tamara
name: Moore, Helen
name: Krüger, Nicole
Publisher: name: Zenodo
Year: 2025
Subjects: open textbooks
educational resources

description: This call-to-action document aims to provide practical steps that help to improve the discoverability of open textbooks. If more open textbooks are included in library discovery systems, they can more easily be reused. Achieving this aim may require several different steps – depending on your starting point.

Anyone who would like to improve the discoverability of open textbooks in their own system can pick the steps that are most suitable for their situation - according to their own knowledge and experience.

The document is a result of focus work done by the LIBER Educational Resources Working Group in 2023-2024.

The steps are:

Step Zero: “Why open textbooks?” - Consider your starting point and national or other circumstances 

Step One: Include existing open textbooks into your collection

Step Two: Communicate within your institution

Step Three: Support teachers

Step Four: Drive institutional change through monitoring and evaluation

Appendices include examples for established collections of open (text-)books, metadata and licence information as well as further reading.
MAKTABDA XALQ DOSTONLARINI О'QITISHNING ESTETIK-PEDAGOGIK ASOSLARI
Creators: name: Sattorov, Shokir
Publisher: name: Zenodo
Year: 2024

description: Mohiyatida odob-axloq, ta’lim-tarbiya jamlangan o‘zbek xalq og‘zaki ijodining har bitta janrida tarbiyaning umumiy jihatlarini aks etadi. Masalan, xalq qo‘shiqlarida odamlarning orzu-armonlari, umidlari, samimiy tuyg’ulari aks etsa, ertaklarda odamlardagi yaxshi fazilatlari bilan bir qatorda  yomon qusurlari ham ko‘rsatiladi. Zohiran ixcham, ma’nan purma’no maqol, hikmatlarda xalq donishmandligi zuhur topganligini ko‘rishimiz mumkin. Topshmoqlar, latifalarda uddaburonlik, topqirlik, fikr-mulohazakorlik namoyon bo‘lganligini ko‘rsak, afsona va rivoyatlarda ibrat, namuna, o‘rnak  kabilarni ko‘ramiz. Qisqasi, xalq og‘zaki namunalarida inson kamoloti uchun zarur xislatlar tarannum etilgani, tarbiyaviy ahamiyat kasb etadi.
GSSO Digital Health Hub Community Dialogue/Hub Development Session Presentation 2
Creators: name: Davison, Kelly
name: Hedderson, Desmond
name: Nair, Rajesh
name: Courtney, Karen
Publisher: name: Zenodo
Year: 2025

description: The second presentation in a series of three supporting the development of the gender, sex and sexual orientation GSSO Digital Health Hub produced for research funded by the Digital Research Alliance of Canada grant proposal titled: Championing the use of Digital Research Infrastructure amongst nursing researchers in Canada: Sex-Gender Digital Health Equity Research Hub proof of concept and knowledge dissemination to national nursing associations.
О'QUVCHILАR ОRАSIDА ЕKОLОGIK TОZА FIKRLАSHNI TАRG'IB QILISHDА АNIMАTSIОN О'QUV VОSITАLАRINING АFZАLLIKLАRI
Creators: name: Sulаymоnоvа, Sаоdаt
Publisher: name: Zenodo
Year: 2024

description: Sо'nggi yillаrdа о'quvchilаrdа еkоlоgik tоzа fikrlаshni rivоjlаntirishdа аnimаtsiоn tа'lim vоsitаlаrining intеgrаtsiyаsigа kаttа е'tibоr bеrildi. Jоzibаdоr vizuаl vа intеrfаоl tаrkibni о‘zidа mujаssаm еtgаn ushbu vоsitаlаr yоsh о‘quvchilаr о‘rtаsidа еkоlоgik xаbаrdоrlikni оshirish vа bаrqаrоr аmаliyоtni rаg‘bаtlаntirishdа sаmаrаli еkаnligini isbоtlаdi. Ushbu mаqоlаdа bоshlаng‘ich vа о‘rtа tа’limdа аnimаtsiоn tа’lim vоsitаlаridаn fоydаlаnishning turli аfzаlliklаri о‘rgаnilib, о‘quvchilаrning аtrоf-muhit muаmmоlаri hаqidаgi tushunchаlаrini оshirishdаgi rоli tа’kidlаnаdi vа ulаrdagi еkоlоgik tоzа xulq-аtvоrni о‘zlаshtirishgа undаydi. Аnimаtsiyаdаn fоydаlаnish nаfаqаt tаlаbаlаrning diqqаtini jаlb qilаdi, bаlki murаkkаb еkоlоgik tushunchаlаrni yаnаdа qulаyrоq vа о'zаrо bоg'lаsh imkоnini bеrаdi. Bundаn tаshqаri, аnimаtsiоn vоsitаlаr tаjribаviy о'rgаnishni оsоnlаshtirаdi, bundа о'quvchilаr insоn hаrаkаtlаrining аtrоf-muhitgа tа'sirini аn'аnаviy usullаr еrishа оlmаydigаn tаrzdа tаsаvvur qilishlаri mumkin.
title: Who You Choose to Be Online: Networked Public Selves
Creators: name: Shewmaker, Caroline
Publisher: name: George Mason University
Year: 2012
Subjects: subject: Facebook
subject: Performance of Self
subject: Identity
subject: Social Network
subject: Textualization
subject: Professionalism

description: This study examines how members of the original Facebook generation changed their performances of identity as they moved from college to professional life. Young professionals between the ages of 25 and 30, who joined Facebook when it was predicated on the college-network design, were interviewed in individual or focus group sessions. These interviews revealed that Facebook users often believe their current online profiles are bound to the context of their collegiate virtual selves, so they control how and to whom their personal information is disseminated. Thus, they create idealized selves for audiences whom they think should be viewing their profiles. Facebook users understand that they have no way to know their actual viewing audience and limited ability to perform impression management in virtual spaces. They are aware that audiences ultimately control how any online performance will be understood and assume that critical judgments, especially about relationship status, will prevail. Users believe written text is easily manipulated and inauthentic, so pictures express the self more accurately and fluidly. Though the Internet was once thought to be a space in which people could develop multiple and unlimited identities, users treat Facebook profiles as reality rather than representations of a reality.
title: Detection of X-Linked Juvenile Retinoschisis
Creators: name: Zhang, Jeremy
Publisher: name: George Mason University
Year: 2021
Subjects: subject: Retinoschisis
subject: Electroretinography
subject: Tomography

description: A child’s education during adolescence is essential for mental and confidence development. As one is exposed to a constantly changing learning environment, unaccounted factors are extremely detrimental. One such factor is X-Linked Juvenile Retinoschisis (XLRS). In general, retinoschisis is a condition in which cysts form within the layers of the retina, causing separation of said layers [1]. Photoreceptor cells within the inner layer are permanently damaged, which ensures near complete blindness. XLRS is a genetic disease that affects an estimated 1 in 5000 males during (pre)adolescence. It causes mutation of the RS1 gene, responsible for creating a retina developmental protein named retinoschisin [2]. The absence of retinoschisin results in an underdeveloped outer layer, causing light to pass through, thus forming the cysts. The disease is incurable, and common visual enhancements cannot be applied to improve conditions [2]. Currently, detection followed by proper accommodation is the only viable prevention method. Such detection methods are genetic testing for the RS1 gene mutation, ocular echography (ultrasound), electroretinography (ERG), and optical coherence tomography (OCT). In this paper, we will mainly discuss ERG and OCT [3][4]. The initial diagnostic tool was electroretinography (ERG), in which a darkness adapted retina is exposed to flashes of light [3]. The photoreceptor cells produce an electrical potential that is measured. The aspects of these measurements will be discussed in this paper. As for recent advancements, OCT is the current method for commercial use, and subsequently generates high resolution 2D or 3D images [4]. This method involves utilizing long wavelength light to penetrate organic tissue. The light contacting the desired scan area is reflected and is processed through a signal receiver, while the other light waves are scattered [4]. In this research paper, we will review the various detection methods along with the complications these methods have on XLRS. Relevant information and data will be obtained and complied to determine the most viable methods, as well as the advantages and disadvantages of each. As XLRS is currently incurable and unpreventable, the importance of precise detection and observation is significant for the betterment and accommodation for those affected.
title: Maternal Behavior and Time Allocation of Red Panda (Ailurus fulgens) in Captivity
Creators: name: Dechanupong, Juthapathra
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Red panda
subject: Ailurus fulgens
subject: Maternal behavior
subject: Conservation
subject: Captive breeding
subject: Cub mortality
subject: Social behavior

description: An understanding of the behavior of animals in captive breeding programs is important for reproductive success and conservation efforts. In altricial mammals, sufficient maternal behavior is essential for the survival of the offspring. The red panda (Ailurus fulgens) is an endangered species with altricial offspring of captive population remaining in the nestbox for the first few months of its life. Captive breeding efforts to secure an insurance population of red pandas has resulted in a 40-50% neonate mortality. Despite the time in the nestbox being crucial to the reproductive success of the red panda, not much is known about the behavior of red panda dam and her interactions with the cubs after birth and during cub-rearing season. This study first explored the post-parturition maternal time allocation of two subspecies of red pandas, A.f. fulgens at the Smithsonian Conservation Biology Institute (SCBI; n=4) and A.f. styani at Chengdu Research Base of Giant Panda Breeding (Chengdu; n=2). Dam behaviors on post-parturition videos recorded from the nestbox were analyzed continuously using Behaviour Pro application to measure duration of state behaviors and rate per hour of events. Resting and grooming made up the largest portion of time allocation per hour (P<0.05). Dams whom failed to rear their cubs to independence spent more time grooming compared to time spent resting (P<0.05), carried their cubs more than the dams who successfully reared their cub, as well as increased the time spent out of the nestbox away from the cub in the first 72hrs. This study also investigated the time allocation of non-pregnant female pandas (A.f. styani) living in groups of more than three adults in Chengdu. The red panda is believed to be a solitary species; no prior research has investigated the behavior of female pandas in a social setting or non-breeding adults during the cub rearing season. Focal observations were conducted during the day using Behaviour Pro application to measure duration of state behaviors and rate per hour of events. Pandas in these social groups mostly performed non-social activities, such as locomoting and straddling. Gregarious behaviors (play, allogroom, and nose-nose) were seen more frequently in one enclosure while agnostic behaviors (aggressive and chase) were observed more in a second enclosure. Small sample sizes, high individual variation and differences in management strategies between the two facilities limit the ability to draw strong conclusions from these studies. Thus, more research on these topics needs to be conducted. However, the knowledge gained from these studies could be used to enhance cub survivorship through adaptive management as well as provide a foundation for more in-depth research to uncover the cause(s) of newborn cub mortality.
Acordo UNESCO e UFV - Cátedra UNESCO Economia Criativa e Políticas Públicas
Creators: name: Emmendoerfer, Magnus
Publisher: name: Zenodo
Year: 2022
Subjects: Creative Economy
Public Policies
UNESCO
UNITWIN Program

description: Acordo de Cooperação Técnica entre UNESCO e UFV (versão em inglês) visando operacionalizar o projeto da Cátedra UNESCO em Economia Criativa e Políticas Públicas no contexto brasileiro. Inclui publicação do estrato do Acordo no Diário Oficial da União (DOU), Brasil, no dia 23/05/2022. Projeto detalhado, disponível em: https://doi.org/10.5281/zenodo.4487085
Acordo UNESCO e UFV - Cátedra UNESCO Economia Criativa e Políticas Públicas
Creators: name: Emmendoerfer, Magnus
Publisher: name: Zenodo
Year: 2022
Subjects: Creative Economy
Public Policies
UNESCO
UNITWIN Program

description: Acordo de Cooperação Técnica entre UNESCO e UFV (versão em inglês) visando operacionalizar o projeto da Cátedra UNESCO em Economia Criativa e Políticas Públicas no contexto brasileiro. Inclui publicação do estrato do Acordo no Diário Oficial da União (DOU), Brasil, no dia 23/05/2022. Inclui ato de nomeação do Coordenador Geral da da Cátedra UNESCO em Economia Criativa e Políticas Públicas, com sede da rede colaborativa na UFV. Projeto detalhado, disponível em: https://doi.org/10.5281/zenodo.4487085
Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination
Creators: name: DeSilva A.M
name: Baric R.S
name: Conrad H
name: Hou Y.J
name: Balmaseda A
name: Ricciardi M.J
name: Crowe, Jr., J.E
name: Kuan G
name: Watkins D.I
name: Tse L.P.V
name: Young E
name: Adams C
name: Kose N
name: Dong S
name: Zhu D
name: Meganck R.M
name: Yount B
name: Harris E
name: Henein S
name: Munt J.E
Publisher: name: Cell Press
Year: 2023

description: The envelope (E) glycoprotein is the primary target of type-specific (TS) neutralizing antibodies (nAbs) after infection with any of the four distinct dengue virus serotypes (DENV1–4). nAbs can be elicited to distinct structural E domains (EDs) I, II, or III. However, the relative contribution of these domain-specific antibodies is unclear. To identify the primary DENV3 nAb targets in sera after natural infection or vaccination, chimeric DENV1 recombinant encoding DENV3 EDI, EDII, or EDIII were generated. DENV3 EDII is the principal target of TS polyclonal nAb responses and encodes two or more neutralizing epitopes. In contrast, some were individuals vaccinated with a DENV3 monovalent vaccine-elicited serum TS nAbs targeting each ED in a subject-dependent fashion, with an emphasis on EDI and EDIII. Vaccine responses were also sensitive to DENV3 genotypic variation. This DENV1/3 panel allows the measurement of serum ED TS nAbs, revealing differences in TS nAb immunity after natural infection or vaccination.
The Path to Genomic Screening—Far From Simple, but the Journey Has Begun
Creators: name: Berg, Jonathan S.
Publisher: name: American Medical Association (AMA)
Year: 2024

description: Today’s genomic technology introduces a multitude of
assays that could be deployed in health care: diagnostic testing
of patients with suspected monogenic conditions,
polygenic risk prediction for common diseases, pharmacogenomic
analysis for drug-gene
interactions, analysis
of tumors for targetable so-matic
sequence variations, and noninvasive screening for pre-natal
chromosomal disorders or occult cancer. Alongside these
approaches we must also grapple with screening of the
ostensibly healthy population for monogenic diseases of
newborns, children, and adults with either targeted or
genome-scale sequencing.
Missed Opportunities for Early De-Escalation of Antipseudomonal Beta-Lactam Antimicrobial Therapy in Enterobacterales Bloodstream Infection
Creators: name: Al-Hasan, Majdi N.
name: Troficanto, Casey
name: Yongue, Emily
name: Reese, Mollie
name: Kohn, Joseph
name: Bookstaver, P. Brandon
name: Winders, Hana R.
Publisher: name: MDPI
Year: 2024

description: Background: Antipseudomonal β-lactams (APBL) are commonly used for empirical therapy of Gram-negative bloodstream infections (BSI). This retrospective cohort study examines risk factors for prolonged APBL use (≥48 h) in patients with Enterobacterales BSI and compares 28-day mortality between early de-escalation of APBL and prolonged APBL therapy. Methods: Adult patients admitted to two community hospitals in South Carolina with Enterobacterales BSI from January 2010 to June 2015 were included in this study. Data were extracted manually from medical records. Multivariate logistic regression and Cox proportional hazards analyses were used to examine predictors of prolonged APBL therapy and mortality, respectively. Results: Among 993 patients with Enterobacterales BSI, 491 (49%) underwent early de-escalation of APBL and 502 (51%) received prolonged APBL therapy. Cancer, immune compromised status, residence at a skilled nursing facility, a high Pitt bacteremia score, non-urinary source of infection, and BSI due to AmpC-producing Enterobacterales were independently associated with prolonged use of APBL. Antimicrobial stewardship interventions were inversely associated with prolonged APBL use. Early de-escalation of APBL was not associated with increased mortality. Conclusions: This study exemplifies the safety and effectiveness of early de-escalation of APBL in Enterobacterales BSI. Antimicrobial stewardship strategies should be implemented to encourage the practice of early de-escalation of antimicrobial therapy, including in high-risk populations.
VPS26 Moonlights as a β‑Arrestin-like Adapter for a 7‑Transmembrane RGS Protein in Arabidopsis thaliana
Creators: name: Velazhahan, Vaithish
name: Lou, Fei
name: Yang, Jing
name: Jones, Alan M.
name: Tunc-Ozdemir, Meral
name: Zhou, Wenbin
name: Tate, Christopher G.
Publisher: name: American Chemical Society (ACS)
Year: 2024

description: Extracellular signals perceived by 7-transmembrane (7TM)-spanning receptors initiate desensitization that involves the removal of these receptors from the plasma membrane. Agonist binding often evokes phosphorylation in the flexible C-terminal region and/or intracellular loop 3 of many 7TM G-protein-coupled receptors in animal cells, which consequently recruits a cytoplasmic intermediate adaptor, β-arrestin, resulting in clathrin-mediated endocytosis (CME) and downstream signaling such as transcriptional changes. Some 7TM receptors undergo CME without recruiting β-arrestin, but it is not clear how. Arrestins are not encoded in the Arabidopsis thaliana genome, yet Arabidopsis cells have a well-characterized signal-induced CME of a 7TM protein, designated Regulator of G Signaling 1 (AtRGS1). Here we show that a component of the retromer complex, Vacuolar Protein Sorting-Associated 26 (VPS26), binds the phosphorylated C-terminal region of AtRGS1 as a VPS26A/B heterodimer to form a complex that is required for downstream signaling. We propose that VPS26 moonlights as an arrestin-like adaptor in the CME of AtRGS1.
Purified diets containing high levels of soluble fiber and grain-based diets promote similar gastrointestinal morphometry yet distinct microbial communities.
Creators: name: Glenny, Elaine M
name: Reed, Kylie K
name: Skinner, Harlyn G
name: McFarlane, Tori L
name: Djukic, Zorka
name: Carroll, Ian M
name: Liu, Jintong
name: Weninger, Alyssa
name: Pellizzon, Michael A
Publisher: name: American Society for Microbiology
Year: 2024

description: Dietary fibers play a crucial role in shaping the gut microbiome and influencing gastrointestinal (GI) physiology. Grain-based diets (GBDs) are widely used in rodent studies, but their utility is limited due to batch-to-batch variability resulting from inconsistent ingredients. Purified diets (PDs) are composed of only known and refined ingredients and offer a solution to the constraints of GBDs. This study aimed to identify a combination of dietary fibers in a purified diet (PD) that promotes optimal murine gut morphometry and a diverse intestinal microbial community. Male C57BL/6J mice were fed either two grain-based diets (GBDs) or four PDs with varying fiber compositions for 28 days. Mice consuming PDs lacking soluble fiber had more gonadal fat (P < 0.05), shorter small intestines (P < 0.05), and lighter ceca (P < 0.05) compared with those fed the LabDiet 5001 GBD. Increasing the proportion of soluble fibers in PDs progressively reduced microbial diversity in the cecum and colon. Multidimensional scaling analysis revealed distinct microbial communities in the cecum and colon between mice fed GBDs and PDs (P < 0.05). Differential abundance analysis identified relatively more Family XII UCG 001 and less Lactococcus in mice fed GBDs relative to mice consuming PDs (P < 0.05). While no PD recapitulated the gut microbial composition of GBDs, PDs with high soluble fiber content best preserved GI morphometry. These findings underscore the importance of considering diet as an experimental variable and highlight the need for a PD formulation that combines the benefits of GBDs on GI health and microbial richness.
IMPORTANCE: Dietary fibers are essential for maintaining gut health. Insoluble fibers aid in fecal bulking and water retention while soluble fiber is a fermentative substrate for intestinal microbial communities. Grain-based diets (GBDs) are commonly used in preclinical research but the variability in ingredients across batches impedes reproducibility. Purified diets (PDs), which are composed of highly refined ingredients, pose a potential solution but the most widely used low-fat control PDs contain no soluble fiber. This study intended to identify a PD with a combination of fibers that promotes murine gut health and microbial diversity. A PD with optimal fiber composition would aid in the standardization and reproducibility of studies investigating intestinal physiology and the gut microbiota.
Functional analysis of the strawberry FaPR1 gene in response to Colletotrichum gloeosporioides infection
Creators: name: Wang, Mingjie
name: Liang, Wenwei
name: Lu, Huiling
name: Yang, Ruihua
name: Hu, Xixi
name: Zhu, Lei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Currently, the PR1 gene in strawberry has not been reported yet. Therefore, in this study, the FaPR1 gene sequence was obtained and cloned based on the transcriptome data of strawberry in response to anthracnose infection. The characteristics of FaPR1-related sequences were analyzed using bioinformatics methods. Moreover, the potential interacting proteins of FaPR1 were predicted using the interaction pairs included in the STRING database, and the interaction between them was verified by the yeast two-hybrid method. In addition, the phenotypic and physiological changes of strawberry materials with overexpressed FaPR1 gene after infection by Colletotrichum gloeosporioides (Penz.) Sacc. were analyzed to provide reference genes and a theoretical basis for molecular breeding for anthracnose resistance. The main results were as follows: (1) The FaPR1 gene encodes a protein containing 162 amino acid residues with an isoelectric point of 5.52; (2) The FaPR1 protein is closely related to Rosa chinensis Jacq. PR1 (RcPR1) protein and Rosa hugonis Hemsl. PR1 (RhPR1) protein; (3) There is an interaction between FaPR1 and the strawberry thaumatin-like protein 1 (FaTLP1); (4) The FaPR1 gene plays an important role in strawberry resistance to anthracnose, and overexpression of the FaPR1 gene can enhance strawberry resistance to this disease.
Federal Policy Platforms and Public Health: Reinforcing the Benefits of Air Pollution Control Devices at Power Plants in the United States.
Creators: name: Willis, Mary D
name: Levy, Jonathan I
name: Kinney, Patrick
name: Arunachalam, Saravanan
name: Prull, Daniel
name: Buonocore, Jonathan J
name: Fisher, Jeremy
name: Sousa, Brian
name: Perera, Frederica
Publisher: name: American Public Health Association
Year: 2024

description: Recent federal policy platforms
have been proposed that include
substantial changes to environmental
regulation at the US Environmental
Protection Agency (EPA). For instance,
the 2025 Presidential Transition Project
(“Project 2025”) has a number of
proposals to change the Clean Air Act
(CAA); and the America First Agenda
has proposals to “modernize” the CAA.
If implemented, these measures may
sharply reduce the future public health
benefits of the CAA. These include possible
harms from ceasing operation of
air pollution control devices (APCDs) at
power plants, which have been a bedrock
of national-scale air pollution
reductions for decades.
Enhancing insights in sexually transmitted infection mapping: Syphilis in Forsyth County, North Carolina, a case study.
Creators: name: Fox, Lani
name: Doherty, Irene
name: Miller, William C
name: Serre, Marc
name: Gesink, Dionne
Publisher: name: Public Library of Science (PLoS)
Year: 2024

description: In 2008-2011 Forsyth County, North Carolina experienced a four-fold increase in syphilis rising to over 35 cases per 100,000 mirroring the 2021 state syphilis rate. Our methodology extends current models with: 1) donut geomasking to enhance resolution while protecting patient privacy; 2) a moving window uniform grid to control the modifiable area unit problem, edge effect and remove kriging islands; and 3) mitigating the "small number problem" with Uniform Model Bayesian Maximum Entropy. Data is 2008-2011 early syphilis cases reported to the NC Department of Health and Human Services for Forsyth County. Results were assessed using latent rate theory cross validation. We show combining a moving window and a UMBME analysis with geomasked data effectively predicted the true or latent syphilis rate 5% to 26% more accurate than the traditional, geopolitical boundary method. It removed kriging islands, reduced background incidence rate to 0, relocated nine outbreak hotspots to more realistic locations, and elucidated hotspot connectivity producing more realistic geographical patterns for targeted insights. Using the Forsyth outbreak as a case study showed how the outbreak emerged from endemic areas spreading through sexual core transmitters and contextualizing the outbreak to current and past outbreaks. As the dynamics of sexually transmitted infections spread have changed to online partnership selection and demographically to include more women, partnership selection continues to remain highly localized. Furthermore, it is important to present methods to increase interpretability and accuracy of visual representations of data.
Determination of volatile organic compounds in four Tuber species, and discrimination of truffles on the basis of their identity, geographic origin and maturity
Creators: name: Sotiropoulou, Νefeli-Sofia
name: Daskalopoulos, Vassileios
name: Bekiaris, Georgios
name: Polemis, Elias
name: Tarantilis, Petros
name: Zervakis, Georgios I.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Truffles (genus Tuber, Ascomycota) are famous for their unique organoleptic characteristics and high commercial value. Their distinctive aroma depends on the relative content of volatile organic compounds (VOCs), and constitutes a principal factor for assessing ascomata quality. In this study, we investigated VOCs composition among mature ascomata of four molecularly identified Tuber species (i.e. T. aestivum, T. bituminatum, T. borchii and T. magnatum) originating from various regions of Greece. Profiles of volatiles from semi-mature T. magnatum samples were also assessed to evaluate the influence of the ascomata maturity stage on VOCs production. SPME-GC-MS analysis revealed the existence of ten chemical classes and 36 VOCs, as well as intra- and interspecific variation in VOCs profiles. Alcohols were found to be abundant in T. aestivum (2-butanol and 1-octen-3-ol), ethers and ketones in T. bituminatum (1-methoxy-3-methyl-benzene and 2-butanone), hydrocarbons in T. borchii (1,3-pentadiene) and organosulfur compounds in T. magnatum (2,4-dithiapentane). Information about VOCs in T. bituminatum is provided for the first time. Furthermore, principal component analysis distinguished the four Tuber species examined, while it also discriminated among T. aestivum samples of various geographic origins. Finally, quantitative modifications in VOCs profiles were associated to the maturity stage of T. magnatum ascomata.
Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy
Creators: name: Mac Grory, Brian
name: Lusk, Jay B.
name: Li, Fan
Publisher: name: American Medical Association (AMA)
Year: 2024

description: To the Editor We read with interest the article by Hathaway et al
and applaud the effort to investigate safety signals of semaglutide.
We were, however, concerned that the methods used
may suffer from bias.
Assessing subnational climate action in G20 cities and regions: Progress and ambition
Creators: name: Hsu, Angel
name: Song, Kaihui
name: Farr, Katherine Burley
Publisher: name: Elsevier
Year: 2024

description: Cities and regional authorities play a crucial role in driving climate action to limit global warming to 1.5°C. Despite their critical importance, significant obstacles in data collection and variability in implementation complicate the assessment of their contributions. This study provides the largest analysis of climate efforts across more than 3,000 cities and 170 regions within the G20 nations, revealing a noticeable uptick in the adoption of medium- to long-term emissions reduction and net-zero targets post-2020. However, over 60% of these subnational entities are failing to meet their climate ambitions, with a larger percentage not achieving the reduction rates necessary to align with the 1.5°C goal. These findings underscore the pressing need for enhanced accountability mechanisms for subnational climate actions. Implementing standardized reporting and boosting transparency are pivotal steps to ensure that local and regional efforts substantively contribute to achieving both national and global climate objectives.