cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Pulmonary Hypertension
title: Scientometric Analysis and Density-Equalizing Mapping
titleType: Subtitle
Creators: name: Goetting, Michael
name: Schwarzer, Mario
name: Gerber, Alexander
name: Klingelhoefer, Doris
name: Groneberg, David A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Pulmonary hypertension (PH) is characterized by the increase of the mean pulmonary arterial pressure in the lung circulation. Despite the large number of experimental and clinical studies conducted on pulmonary hypertension, there is no comprehensive work that analyzed the global research activity on PH so far. We retrieved the bibliometric data of the publications on pulmonary hypertension for two periods from the Web of science database. Here, we set the first investigation period from 1900 to 2007 (t1) due to the cited half life of articles and the relating difficulties to interpret the citation parameters. The second evaluation period (t2) covers the time interval from 2008 onwards including the year 2015. The data were analyzed and processed to density-equalizing maps using the NewQIS platform. A total number of 18,986 publications were identified in t1 that come from 85 countries. The US published the highest number of publications (n = 7,290), followed by the UK, Germany, Japan and France. In t2 19,676 items could be found worked out by 130 countries. The raking started just the same with the USA as most publishing nation with 7,127 publications on PH, followed by the UK and Germany. Japan fell back on 6th place, whereas China came into view on the 5th position. Analyzing the average citation rate as a parameter for research quality, Mexico reached the highest value in t1 and Ireland in t2. While, the country specific h-index underlined the leading position of the US research in both evaluation periods again. The average number of international collaboration items was expanding from none in 1978 to 530 items in 2015 with the USA as the country with the highest number of collaboration articles. The present study is the first large scale density-equalizing mapping and scientometric analysis of global PH research activity. Our data draw a sketch of the global research architecture in this field, indicating a need for specific research programs in countries with a lower human development index.
Factor analysis and dimensionality assessment of epistemic orientation survey for Elementary science teachers
Creators: name: Ding, Chenchen
Publisher: name: University of Iowa
Year: 2023
Subjects: dimensionality
epistemic orientation survey
factor analysis
public abstract

description: This research investigated the factor structures of an Epistemic Orientation Survey (EOS) (Suh et al., 2021), a five-point Likert scale. The EOS has four subdomains and has 44 items in total: Epistemic alignment (EA) measured by 24 items, Classroom authority (CA) measured by 8 items, Epistemic nature of knowledge (ENK) measured by 8 items, and Student ability (SA) measured by 4 items. Item factor analysis (IFA) with WLSMV as an estimator was used to estimate the factor structures for each subdomain at each of four occasions. DIFFTEST was used for model comparisons. It was found that the epistemic alignment (EA) with 24 items had three factors across four occasions: knowledge construction (12 items), knowledge replication (8 items), and correct answers (4) items. By deleting one item having consistently low polychoric correlations across occasions, the classroom authority (CA) with 7 items had a one-factor structure across four occasions. The Epistemic nature of knowledge (ENK) with 8 items had a two-factor structure on occasions 1 and 2, but a one-factor structure on occasions 3 and 4. The student ability (SA) dimension with 4 items consistently had a one-factor structure across time. In sum, the hypothesized four-subdomain EOS should have six subdomains instead.
Environmental and evolutionary consequences of altered atmospheric oxygen in Drosophila melanogaster
Creators: name: Charette, Marc
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Evolution and Development.

description: Experimental evolution was used to independently evolve 12 replicate populations of Drosophila melanogaster for 34+ generations in one of three treatment environments of varying PO2: hypoxia (5.0-10.1 kPa), normoxia (21.3 kPa), and hyperoxia (40.5 kPa). Several traits related to whole animal performance and metabolism were monitored during experimental evolution and several common garden assays were performed at various stages to directly compare evolved and acclimatory differences between treatments. Results clearly demonstrate the evolution of increased anoxia tolerance in hypoxia-evolved populations, suggesting adaptation to this environment. This was correlated with an increase in citrate synthase activity compared to normoxic (control) populations, suggesting an increase in mitochondrial density in these populations. In contrast, no direct evidence of increased performance of the hyperoxia-evolved populations was detected, although an evolutionary cost was observed as a substantial decline in anoxia tolerance. Changes in performance did not result in an increase in any of the fitness components measured, including productivity and longevity, suggesting that these assays failed to capture the components of fitness relevant to adaptation.
title: Prozesskettenorientierte Ermittlung der Material- und Energieeffizienzpotentiale in der Zementindustrie
title: Prozesskettenorientierte Ermittlung der Material- und Energieeffizienzpotentiale in der Zementindustrie
titleType: AlternativeTitle
Creators: name: Ruppert, Johannes
name: Wagener, Carina
name: Palm, Sebastian
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Zementindustrie
subject: Materialeffizienz
subject: Abwärmenutzung
subject: Zementherstellung
subject: Energieeffizenz
subject: Klinkerherstellung
subject: Betonherstellung
subject: Prozessabwärmenutzung
subject: Wirtschaft | Konsum

description: Im Rahmen des Projektes wird herausgearbeitet, welchen Beitrag eine material- und energieintensive Industrie wie die Zementindustrie zur Ressourcenschonung und zum Klimaschutz leisten kann, welche Hemmnisse es gibt und wie man diese ausräumen könnte. Anhand verschiedener Szenarien wird gezeigt, dass mit den aktuell eingesetzten Technologien die Potenziale zur Minderung von CO2 -Emissionen innerhalb der Zementindustrie selbst begrenzt sind. Der effizienten Nutzung von Zementklinker kommt bei den brancheninternen Maßnahmen eine besondere Bedeutung zu. Für die sinnvolle und zeitgerechte Umsetzung notwendiger Break-Through-Technologien in der Zementindustrie ist der Dialog zwischen Industrie, Politik und Gesellschaft unabdingbar. Zudem ist insbesondere die Unterstützung der gezielten Nachfrage nach CO2-armen und ressourceneffizienten Zementen und Bauprodukten entscheidend. Quelle: www.umweltbundesamt.de
description: Im Rahmen des Projektes wird herausgearbeitet, welchen Beitrag eine material- und energieintensive Industrie wie die Zementindustrie zur Ressourcenschonung und zum ⁠Klimaschutz⁠ leisten kann, welche Hemmnisse es gibt und wie man diese ausräumen könnte. Anhand verschiedener Szenarien wird gezeigt, dass mit den aktuell eingesetzten Technologien die Potenziale zur Minderung von ⁠CO2⁠-Emissionen innerhalb der Zementindustrie selbst begrenzt sind. Der effizienten Nutzung von Zementklinker kommt bei den brancheninternen Maßnahmen eine besondere Bedeutung zu. Für die sinnvolle und zeitgerechte Umsetzung notwendiger Break-Through-Technologien in der Zementindustrie ist der Dialog zwischen Industrie, Politik und Gesellschaft unabdingbar. Zudem ist insbesondere die Unterstützung der gezielten Nachfrage nach CO2-armen und ressourceneffizienten Zementen und Bauprodukten entscheidend.
Improving investors' judgments with market benchmarks
Creators: name: Hinds, Cory
Publisher: name: University of Iowa
Year: 2023
Subjects: Digital engagement practices
Investor judgments
Overconfidence
Performance benchmarks
public abstract
Experimental Design

description: Personal portfolio returns conflate overall market returns and abnormal returns. I use an experiment to disentangle when past market returns cause individual investors to become overconfident and test whether a salient market benchmark reduces overconfidence and improves investors’ judgments. Participants are experienced investors who make simulated trades on a virtual stock exchange and estimate their future relative investing performance. I document that positive past market returns lead investors to become more overconfident. I also find that presenting investors with a salient market benchmark mitigates this effect and helps investors make judgments consistent with prescriptive investing advice. Thus, my findings suggest salient market benchmarks can serve as a relatively simple and implementable visual cue that can reduce investor overconfidence and its adverse consequences. My findings address concerns among regulators about how to best protect investors and contribute to growing research in accounting on the judgments and behaviors of individual investors in capital markets.
title: Cas d’utilisation de DataCite dans le monde: Centre national de la recherche scientifique et technique (CNRST), Maroc
Creators: name: EL MAGUIRI, Fadoua
name: Mostafa, Mohamad
Publisher: name: DataCite
publisherIdentifier: https://ror.org/04wxnsj81
publisherIdentifierScheme: ROR
Year: 2024

description: Cas d’utilisation de DataCite dans le monde: Bienvenue dans notre série de blogs qui met en lumière comment les institutions de recherche intègrent l’infrastructure de DataCite dans leurs systèmes et flux de travail. Rejoignez-nous pour explorer des exemples concrets, des meilleures pratiques et l’impact de la communauté DataCite.

Fadoua El Maguiri est la directrice de l’Institut Marocain de l’Information Scientifique et Technique (IMIST), une entité relevant du Centre National pour la Recherche Scientifique et Technique (CNRST) au Maroc. De plus, Fadoua gère le Portail National PRSM pour la publication et l’hébergement en ligne des Revues Scientifiques Marocaines.
3707583.pdf
Creators: name: Ren, Liqing
name: Hurwitz, Ilan
name: Raanan, Dekel
name: Oulevey, Patric
name: Oron, Dan
name: Silberberg, Yaron
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The supplementary document includes the support information
title: Doll house
title: a feminist rewrite of familiar narratives
titleType: Subtitle
Creators: name: Hallinan, Emmalee Anne
Publisher: name: University of Iowa
Year: 2023
Subjects: Archive
Corporeality
Performativity
Temporality
public abstract
Dance
Performing Arts

description: The performative and choreographic investigations reflected in this process and product of thesis research are situated inside projects of autoethnography and embodied knowing. I, as the choreographer and performing subject, follow an agenda of re-entering archival pasts of lived experience in search of latent possibility. These investigations in potential pasts pointedly dialogue with theories of inscription and gendered performance brought forth by Butler, Foucault, Jones, Noland & Ness and others – and in feminist impulse, negotiate caveats of power accrued through trained excellence in culturally specific codes. In positioning my contemporary body against moving images of past movement-specific chronicles, I aim to open a portal for rewriting them in the present. I question what might be unlocked, known, or understood in difference, when re-viewing, and re-animating personal video archives made visible through my storehouse of VHS tapes and my body alike. In curating and arranging select capsules of past lived experience and projecting them for viewership adjacent to my Self, in the here and now, I hone a capacity to exercise agency over past narratives – overriding them in fictive spirit or juxtaposing them with the impulse of an instigator. The audience, as witness to my body/mind/soul across dimensions of temporality accompanies me in a project of breaching constructed meanings and messages. In the spirit of reckoning and futuring, I will to resituate myself in a past that is simultaneously hosted in a present Self – leveraging this duality toward agency while maintaining cognizance of my boundedness.
description: DOI: https://doi.org/10.25820/jdps-pd03
Scheduling in multiple processor real-time systems.
Creators: name: Lachance, Jean-Pierre.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Electronics and Electrical.

description: The objective of this thesis is to investigate the effects of different dynamic scheduling heuristic rules on the design of Real-Time Systems (RTS) which allow for the execution of complex responses. Complex responses are characterized by the concurrent nature of activity execution. RTS design will be done through the use of a simulator which allows for the selection of the external event characteristics, definition of the RTS (processes, due dates, activity-to-resource allocations with activity execution times) and selection of different activity scheduling schemes (first-come first-served, earliest due date, shortest activity first, etc. ...). Statistics, such as response execution times, waiting times of ready-to-execute activities, percentage of responses that are tardy and resource utilization, are gathered and provided to the designer. These statistics allow the designer to refine the design, by changing system parameters, until satisfactory RTS operation is achieved. In this study, the RTS will be implemented on a centrally coordinated multiple processor system topology. (Abstract shortened by UMI.)
3707583.pdf
Creators: name: Ren, Liqing
name: Hurwitz, Ilan
name: Raanan, Dekel
name: Oulevey, Patric
name: Oron, Dan
name: Silberberg, Yaron
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: The supplementary document includes the support information
title: Development of an analytical method to quantify pharmaceuticals in fish tissues by liquid chromatography-tandem mass spectrometry detection and application to environmental samples
title: Development of an analytical method to quantify pharmaceuticals in fish tissues by liquid chromatography-tandem mass spectrometry detection and application to environmental samples
titleType: AlternativeTitle
Creators: name: Boulard, Lise
name: Parrhysius, Pia
name: Koschorreck, Jan
name: Jacobs, Björn
Publisher: name: My University
Year: 2020

description: A sensitive multiresidue method was developed to quantify 35 pharmaceuticals and 28 metabolites/transformation products (TPs) in fish liver, fish fillet and fish plasma via LC-MS/MS. The method was designed to cover a broad range of substance polarities. This objective was realized by using non-discriminating sample clean-ups including separation technique based on size exclusion, namely restricted access media (RAM) chromatography. This universal clean-up allows for an easy integration of further organic micropollutants into the analytical method. Limits of quantification (LOQ) ranged from 0.05 to 5.5 ng/mL in fish plasma, from 0.1 to 19 ng/g d.w. (dry weight) in fish fillet and from 0.46 to 48 ng/g d.w. in fish liver. The method was applied for the analysis of fillets and livers of breams from the rivers Rhine and Saar, the Teltow Canal as well as carps kept in fish monitoring ponds fed by effluent from municipal wastewater treatment plants. This allowed for the first detection of 17 analytes including 10 metabolites/TPs such as gabapentin lactam and norlidocaine in fish tissues. These results highlight the importance of including metabolites and transformation products of pharmaceuticals in fish monitoring campaigns and further investigating their potential effects. © 2020 The Authors
Why I am a champion for Tasmania's NBN
Creators: name: Alexander, Darren
Publisher: name: Swinburne
Year: 2024

description: Much has been written about a reported high cost of the NBN. This paper looks at some of its benefits that are helping to make Tasmania potentially as much a centre of the economic world as London, New York, Sydney or Melbourne. Beyond economics, and significantly for Tasmania, it looks further at how NBN makes it possible to share in world trade from this environmentally rich part of the world with its wealth of quality human resources eager to fully exercise their worldly skills within the comfortable, relaxed and healthy natural lifestyle that Tasmania wishes to preserve.
Tissue enzyme changes in air-exposed American eels.
Creators: name: Juergensen, Lars Stephen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Ecology.

description: American eels (Anguilla rostrata) are known to leave the water for excursions onto land despite lacking specialized air breathing organs. Other studies have established that the eel suffers from acidosis and hypoxemia as a result of this air exposure, but the survival of the eels despite these conditions demonstrates a large degree of tolerance to these effects. This thesis will investigate the changes in tissue enzymes of the American eel as a result of air exposure. It is the hypothesis of this experiment that conditions of air exposure eels will undergo a metabolic reorganization including an initial Pasteur effect and metabolic depression indicated by changes in enzyme activities and metabolite concentrations. Eels were air exposed for 3, 5 or 10 days in boxes ensuring constant temperature and humidity. Maximal activities were determined in white muscle, gill and posterior kidney tissues harvested immediately following the particular air exposure period; as a result of technical difficulties, liver was unavailable for study. Enzymes assayed included those key in glycolysis (PFK, PK, LDH), glycogen metabolism (GPase and GSase) and gluconeogenesis (GDH, AspAT, AlaAT, and PEPCK). In addition, kinetic analysis was undertaken for PFK and PK in harvested posterior kidney. Blood collected at the time of harvest was analyzed for glucose, lactate and cortisol to determine circulating levels. Muscle samples were also analyzed for glycogen content. Although changes in enzyme rates, enzyme kinetics and metabolites were observed to result from the air exposure, it could not be concluded that the changes were part of a concerted metabolic depression.
Rheological characterization of complex materials and modeling of shear-free flows.
Creators: name: Beaulne, Michel A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Engineering, Chemical.

description: The behaviour of complex materials, the main study of rheology, is investigated in this work. In an effort to better understand these materials, a two-step process was undertaken. First, the nonlinear behaviour of such materials was determined in a laboratory. Second, experimental measurements were extracted from the literature with respect to shear-free flows of complex materials and simulations were performed for the shear-five flows in question. These flows involve uniaxial extension in the case of fiber spinning and film casting, and biaxial extension in the caw of film blowing. Rheological experiments were conducted on polymer solutions, namely poly(ethylene oxide) and polyacrylamide, at room temperature and on a polypropylene (PP) polymer melt at high temperature, with a Weissenberg rheogoniometer in a laboratory. The shear viscosity and first normal stress difference were measured at varying shear rates. An integral constitutive equation of the K-BKZ type was used to predict the nonlinear behaviour of these materials. Transient regression was performed to find the parameters of the K-BKZ model for the U-Stamylan low-density polyethylene (LDPE), and predictions for steady-state materials functions were given. Fiber-spinning simulations were undertaken for a series of complex materials at a wide range of operating conditions. Film-casting simulations were also undertaken for a series of complex materials. (Abstract shortened by UMI.)
Alpha-Galactosidase A p.A143T, a non-Fabry disease-causing variant
Creators: name: Lenders, Malte
name: Weidemann, Frank
name: Kurschat, Christine
name: Canaan-Kühl, Sima
name: Duning, Thomas
name: Stypmann, Jörg
name: Schmitz, Boris
name: Reiermann, Stefanie
name: Krämer, Johannes
name: Blaschke, Daniela
name: Wanner, Christoph
name: Brand, Stefan-Martin
name: Brand, Eva
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Fabry disease
subject: Lyso-Gb3
subject: Variant of unknown significance
subject: Late-onset
subject: GLA mutation
subject: Stroke
subject: Genotype
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Fabry disease (FD) is an X-linked multisystemic disorder with a heterogeneous phenotype. Especially atypical or late-onset type 2 phenotypes present a therapeutical dilemma. Methods To determine the clinical impact of the alpha-Galactosidase A (GLA) p.A143T/ c.427G > A variation, we retrospectively analyzed 25 p.A143T patients in comparison to 58 FD patients with other missense mutations. Results p.A143T patients suffering from stroke/ transient ischemic attacks had slightly decreased residual GLA activities, and/or increased lyso-Gb3 levels, suspecting FD. However, most male p.A143T patients presented with significant residual GLA activity (~50 % of reference), which was associated with normal lyso-Gb3 levels. Additionally, p.A143T patients showed less severe FD-typical symptoms and absent FD-typical renal and cardiac involvement in comparison to FD patients with other missense mutations. Two tested female p.A143T patients with stroke/TIA did not show skewed X chromosome inactivation. No accumulation of neurologic events in family members of p.A143T patients with stroke/transient ischemic attacks was observed. Conclusions We conclude that GLA p.A143T seems to be most likely a neutral variant or a possible modifier instead of a disease-causing mutation. Therefore, we suggest that p.A143T patients with stroke/transient ischemic attacks of unknown etiology should be further evaluated, since the diagnosis of FD is not probable and subsequent ERT or chaperone treatment should not be an unreflected option.
3708624.pdf
Creators: name: Fang, Liang
name: LUO, ZHI-HAO
name: Cao, Xiaoping
name: Zheng, Shuang
name: Cai, Xinlun
name: Wang, Jian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Dictionary or AI? Sentiment Analysis for Spanish Enlightenment Periodicals
Creators: name: Krušić, Lucija
name: Scholger, Martina
Publisher: name: Zenodo
Year: 2023

description: Presentation held at the "CLARC 2023 – Language and Language Data Conference" In Rijeka, Croatia on the 29th of september 2023. The talk presented a comparison and evaluation of Sentiment Analysis methods (including a custom dictionary, BERT and GPT models) for a corpus of Enlightenment periodicals.
Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers
Creators: name: Singh, Kriti
name: Munuganti, Ravi S. N.
name: Lallous, Nada
name: Dalal, Kush
name: Yoon, Ji Soo
name: Sharma, Aishwariya
name: Yamazaki, Takeshi
name: Cherkasov, Artem
name: Rennie, Paul S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Estrogen receptor-α positive (ERα+) breast cancers represent 75% of all invasive breast cancer cases, while de novo or acquired resistance to ER-directed therapy is also on the rise. Numerous factors contribute to this phenomenon including the recently-reported ESR1 gene mutations such as Y537S, which amplifies co-activator interactions with ERα and promotes constitutive activation of ERα function. Herein, we propose that direct targeting of the activation function-2 (AF2) site on ERα represents a promising alternative therapeutic strategy to overcome mutation-driven resistance in breast cancer. A systematic computer-guided drug discovery approach was employed to develop a potent ERα inhibitor that was extensively evaluated by a series of experiments to confirm its AF2-specific activity. We demonstrate that the developed small-molecule inhibitor effectively prevents ERα-coactivator interactions and exhibits a strong anti-proliferative effect against tamoxifen-resistant cells, as well as downregulates ERα-dependent genes and effectively diminishes the receptor binding to chromatin. Notably, the identified lead compound successfully inhibits known constitutively-active, resistance-associated mutant forms of ERα observed in clinical settings. Overall, this study reports the development of a novel class of ERα AF2 inhibitors, which have the potential to effectively inhibit ERα activity by a unique mechanism and to circumvent the issue of mutation-driven resistance in breast cancer.
Development of an image-based system for assessment of bone density, geometry, and micro-architecture suitable for human studies
Creators: name: Zhang, Xiaoliu
Publisher: name: University of Iowa
Year: 2022
Subjects: Anatomical subregion
Hip CT
Hip MRI
Orientation
Shape modeling
Trabecular bone
public abstract

description: Osteoporosis is a common age-related disease characterized by reduced bone mineral density (BMD), micro-structural deterioration, and enhanced fracture-risk. There is compelling evidence that bone micro-structural properties are strong determinants of bone strength and fracture-risk. Valid and reliable measures of effective trabecular bone (Tb) micro-structural features are of paramount significance in early detection of osteoporosis and accurate assessment of fracture-risk. It has been shown using biomechanical modelling that transverse trabeculae are important players in arresting the buckling of longitudinal trabeculae that causes compressive fractures. One of the aims of my PhD research was to develop and validate a new method of characterizing transverse and longitudinal trabeculae at in vivo imaging resolution and retrospectively examine its application using existing human study data. A set of cadaveric ankle specimens (n = 19) were collected, prepared, and scanned using CT and micro-CT imaging protocols, to validate new methods.
description: Emerging in vivo imaging technologies allow us to collect bone data at the hip. A major challenge in this research approach is related to selection of standardized anatomic ROIs in hip scans of individual subjects. The second aim of my PhD research was to develop and validate an active-shape-model (ASM) based method to automatically generate anatomically standardized ROIs that will adjust for subject-specific variations in femur geometry and shape. Also, the ASM may be used to compute effective geometric features from individual femur shape instances. To overcome the challenges of building the ASM of the complex three-dimensional (3-D) shape of the femur, a novel geodesic-editor graphical-user-interface (GUI) has been designed and developed that allows drawing and manipulating lines and landmarks on arbitrary curved surfaces as compared to 2-D planes used by conventional GUIs. Also, a new theory and algorithm of shape-based smoothing have been developed to smooth image-based femur shape and reduce digital artifacts.
description: The third aim of my PhD research program was to develop a comprehensive manual quality control protocol for quantitative in vivo bone micro-structural imaging cascades for human studies. The purpose of this aim is to identify and resolve failure points in the large and complex image processing protocol for quantitative in vivo bone micro-structural imaging, developed in our laboratory, which uses several study-specific assumptions to optimize and automate the overall computational system.
Studies of COVID-19 outbreak control using agent-based modeling
Creators: name: Liu, Ruicheng
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract

description: A worldwide COVID-19 epidemic is now underway. The majority of current research focuses on issues such as virus transmission, asymptomatic and presymptomatic virus shedding, vaccine development, and so on. In this research, we created an agent-based model to explore COVID-19 epidemics and outbreak control, primarily in urban areas, as opposed to using mathematical and statistical models. It was possible to construct rules for human interaction and virus infectiousness. At first, the control measures, such as social distance, self-quarantine, and community quarantine, were evaluated separately. Both community quarantine and self-quarantine were scaled so that their impacts on the outbreak control can be quantitatively evaluated. The dataset was then utilized to train an artificial neural network, logistic regression classifier, and nonlinear support vector machine to forecast epidemic control by employing a mix of control strategies, using data acquired from intense simulations. We also ran a case study to anticipate the number of new COVID-19 cases each day in New York City after March 2, 2020, and compared the simulated results to the published data.
Building Bridges
Creators: name: Gibis, Claudia
name: Zirkel, Alexandra
Publisher: name: My University
Year: 2013

description: Linking the raft of emissions trading systems springing up across the globe is an important step towards forging a worldwide carbon market. But if not implemented correctly, the process could undermine emission reduction efforts, warn Claudia Gibis and Alexandra Zirkel.
Quelle: http://www.environmental-finance.com/
Acute plasma tryptophan depletion and smoking abstinence: Withdrawal, mood and quantitative EEG correlates and the acute smoking response.
Creators: name: Perugini, Mary.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Public Health.

description: Since research has implicated a role for serotonin function in smoking abstinence and in smoking behavior, the present study examined the effects of a tryptophan-depleting amino acid mixture and the subsequent smoking of a single cigarette on the nicotine withdrawal syndrome, mood and quantitative electroencephalography (EEG) in chronic smokers acutely deprived of smoking. In a double-blind, placebo-controlled, repeated measures design, eighteen male smokers were tested on two separate occasions, three days apart. On each occasion they: (a) ingested a nutritionally balanced amino acid mixture containing tryptophan or ingested a similar mixture devoid of tryptophan, and (b) sham smoked and smoked a single cigarette. Nicotine withdrawal symptoms, mood states, EEG and expired-breath carbon monoxide (CO) concentrations were measured four times: (a) immediately before smoking deprivation and ingestion of the amino acid mixtures (baseline); (b) 5 hr after smoking abstinence and ingestion of the amino acid mixtures; (c) immediately after sham smoking, and (d) after cigarette smoking. Total plasma tryptophan levels were measured two times: before and 5 hr after amino acid mixture ingestion. A significant reduction of plasma tryptophan (71%) was achieved by the tryptophan-depletion mixture. Smoking deprivation led to clear time-dependent increases in negative mood state and nicotine withdrawal ratings and reduced EEG activation. While acute tryptophan depletion did not exacerbate this withdrawal in abstinent smokers as evidenced by the absence of change in mood and withdrawal ratings, it was associated with altered brain state arousal as indicated by the reduction in alpha2 amplitude. While the smoking of a cigarette reduced and reversed to baseline some of the smoking abstinence-induced effects, these effects were not influenced by the tryptophan depletion mixture. Localized and lateralized EEG effects in abstinent smokers and following tryptophan depletion were also not observed. These findings suggest that in chronic male smokers reduced serotonin neurotransmission is not an important characteristic of acute smoking withdrawal effects. These results do not support previous research that has implicated altered serotonin function in tobacco withdrawal and in smoking behavior.
"Red Lines" and the Syrian Civil War: The Power of a President
Creators: name: Kurland, Sam
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: College students' writings, chemical weapons, red lines, presidential rhetoric, Syrian War,

description: This essay won or received an honorable mention for The Boothe Prize for excellence in first-year writing. The Boothe Prize recognizes and rewards outstanding expository and argumentative writing by undergraduate students in first-year classes that satisfy the WR 1 requirement. In each award-winning essay, student writers demonstrate clarity of argument, excellent integration of research-based evidence, and compelling prose style.
This essay focuses on the case of President Barack Obama’s public declaration in 2012 that the use of chemical weapons in Syria would amount to crossing an inviolable “red line” and bring about a swift intervention. Kurland points out the potential risks and pitfalls of this “red line” or ultimatum rhetoric, and argues that we can learn much about the potency of presidential rhetoric in delimiting the actions of combatants in conflict zones and in achieving consensus for response.
Role of the Adsorption of Alkali Cations on Ultrathin $n$-Layers of Two-dimensional Perovskites
Creators: name: Ribeiro, Israel C.
name: Moraes, Pedro Ivo R.
name: Bittencourt, Albert F. B.
name: Da Silva, Juarez L. F.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Metal-halide semiconductors have great potential for real-life photovoltaic applications; however, surface defects induce several challenges to the thermodynamic stability. Here, we employed density functional theory calculations within van der Waals corrections (D3) to investigate the role of monovalent cations (Li, Na, K, Rb and Cs) in the passivation of 2D perovskite ultrathin films.
title: Path to the third pole
title: for sinfonietta
titleType: Subtitle
Creators: name: Cai, Hongwei
Publisher: name: University of Iowa
Year: 2023
Subjects: Contemporary Classical Music
Cultural Musical Synthesis
Orchestral Composition
Tibetan Buddhism
Tibetan Culture
Western Classical Music Fusion

description: “Path to the Third Pole” is a musical composition that harmonizes the spiritual essence of Tibetan Buddhism with Western classical music’s aesthetic sensibilities. This twenty-two-minute piece for a sinfonietta ensemble delves into the acoustic and spiritual realms of Tibetan cultural practices, including chanting, ritual purification, and sky burial. The work juxtaposes the organic flow of the golden ratio, as exemplified in the third movement, with the mathematical precision of prime numbers structuring the second movement. This interplay of Eastern and Western philosophical concepts is further enriched by a personal narrative of intercultural exploration and a deepening connection with Tibetan spirituality. The composition stands as a testament to the transformative power of music, bridging cultural divides and inviting listeners into a contemplative space of cultural convergence and spiritual introspection.
Cognitive representations as a measure of present and future behavior
Creators: name: Rangel, Benjamin
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: The performance of goal directed behavior requires that the appropriate context, actions, and expected outcomes be properly represented within our minds. These individual, lower representations are thought to be integrated into higher-order, conjunctive representations which have the advantage of being more goal specific and stable over time. Additionally, it is thought that these conjunctive representations, once constructed, can be stored in episodic memory, and subsequently retrieved to facilitate future performance. However, due to the specificity of these conjunctions, they can be detrimental to behavior if they are activated in the wrong context. Thus, situations similar, but not identical to those under which the conjunction was formed, can lead to their automatic retrieval which requires the implementation of control mechanisms to resolve the conflict. The detriment to performance as a result of this has been termed the “partial repetition cost.” In this thesis, we utilize multivariate pattern analysis of EEG data to provide evidence that previously formed conjunctions can directly affect future behavior. Additionally, we explore the influence that surprising stimuli play in the binding and subsequent retrieval of these conjunctions, when they are presented during task performance, and between task switches.
The role of circulating catecholamines in the regulation of breathing in teleosts.
Creators: name: Kinkead, Richard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Animal Physiology.

description: This thesis attempts to elucidate the role of epinephrine and/or norepinephrine in the regulation of ventilation in teleosts while also considering the effects of other potential ventilatory modulators. The ventilatory responses to various external respiratory challenges were quantified and compared with those in fish pre-treated with adrenoceptor antagonists. The effects of experimental elevation of circulating catecholamines on gill ventilation volume (Vw) were assessed. During hypoxia, pre-treatment of fish with either $\alpha$- or $\beta$-adrenoceptor antagonists did not affect the ventilatory response of rainbow trout (Oncorhyncus mykiss) or Atlantic cod (Gadus morhua), regardless of the degree of hypoxia used and the corresponding effects on circulating catecholamine levels. Furthermore, since increases in Vw were observed under mild hypoxia or hypercapnia it is concluded that elevation of circulating catecholamines is not a prerequisite for hyperventilatory responses to these stimuli. Pre-treatment of trout with a $\beta$-adrenoceptor antagonist (propranolol) prior to exposure to external hypercapnia prevented a sustained hyperventilation despite the absence of significantly elevated catecholamines in the circulation. This revealed that catecholamines of non-humoral origin are involved in the hyperventilatory response to hypercapnia. It is unlikely, at least in trout, that catecholamines play a stimulatory role in the regulation of ventilation. Respiratory acidosis may play a role in the control of ventilation in this species since external hypercapnia prevented the hypoventilatory response normally associated with hyperoxia. (Abstract shortened by UMI.)
Therapeutic disruption of RAD52-ssDNA complexation using novel drug-like scaffolds
Creators: name: Bhat, Divya S
Publisher: name: University of Iowa
Year: 2023
Subjects: Drug Discovery
public abstract
Cancer Biology

description: DNA repair protein RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose polymerase (PARP) inhibitors, pharmacological inhibition of RAD52 is synthetically lethal with defects in genome caretakers such as breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2) (~25% of breast and ovarian cancers). The genome stabilizing functions of RAD52 that underlies its use in cells displaying so-called BRCAness phenotype depends on the ability of RAD52 to bind ssDNA. However, there remains a dearth of small molecule inhibitors that can abrogate the interaction between ssDNA and RAD52. This is because structure activity relationships for RAD52 are complex which makes it challenging to transform previously identified natural product and repurposed compounds that inhibit the RAD52-ssDNA interaction into drug like compounds with good ADME qualities that are suitable for clinical use.
description: Using pharmacophoric informatics on the RAD52 complexation by epigallocatechin (EGC), and the Enamine in silico REAL database, we have identified six distinct chemical scaffolds that occupy the same physical space on RAD52 as EGC. I performed FRET-based assays to characterize these six compounds and confirm their ability to act as RAD52 inhibitors. All six compounds were shown to inhibit the complexation between ssDNA and RAD52 (IC50 ~23-1200 μM). Moreover, two of the compounds (Z56 and Z99) were capable of selectively killing BRCA1 and BRCA2 mutated cells. While Z56 had no effect on the ssDNA-binding protein RPA and was toxic to BRCA2-mutant cells only, Z99 inhibited both proteins and displayed toxicity towards BRCA2-complemented cells as well as BRCA proficient cells. Optimization of the Z99 scaffold resulted in a set of more powerful and selective inhibitors (IC50 ~1.3-8 μM), which were only toxic to BRCA1 and BRCA2-mutant cells.
description: Moreover, our RAD52 inhibitors could also affect the proliferation and clonogenic potential of glioblastoma cells that don’t have mutations in BRCA1 and BRCA2. This data suggests that RAD52 plays a role in the survival of glioblastoma cells and provides impetus for the expansion of RAD52 inhibitor treatment into other types of cancers outside of BRCA-deficient breast, ovarian and pancreatic malignancies. Thus, RAD52 complexation by Z56, Z99 and its more specific derivatives provides a roadmap for further improvement of our lead compounds.
title: Periodic limb movements during REM sleep in multiple sclerosis
title: a previously undescribed entity
titleType: Subtitle
Creators: name: Veauthier, Christian
name: Gaede, Gunnar
name: Radbruch, Helena
name: Sieb, Joern-Peter
name: Wernecke, Klaus-Dieter
name: Paul, Friedemann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: restless legs syndrome
subject: spinal cord
subject: sleep disorders
subject: disability
subject: clinical neurophysiology
subject: polysomnography
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: There are few studies describing periodic limb movement syndrome (PLMS) in rapid eye movement (REM) sleep in patients with narcolepsy, restless legs syndrome, REM sleep behavior disorder, and spinal cord injury, and to a lesser extent, in insomnia patients and healthy controls, but no published cases in multiple sclerosis (MS). The aim of this study was to investigate PLMS in REM sleep in MS and to analyze whether it is associated with age, sex, disability, and laboratory findings. Methods: From a study of MS patients originally published in 2011, we retrospectively analyzed periodic limb movements (PLMs) during REM sleep by classifying patients into two subgroups: PLM during REM sleep greater than or equal to ten per hour of REM sleep (n=7) vs less than ten per hour of REM sleep (n=59). A univariate analysis between PLM and disability, age, sex, laboratory findings, and polysomnographic data was performed. Results: MS patients with more than ten PLMs per hour of REM sleep showed a significantly higher disability measured by the Kurtzke expanded disability status scale (EDSS) (P=0.023). The presence of more than ten PLMs per hour of REM sleep was associated with a greater likelihood of disability (odds ratio 22.1; 95% confidence interval 3.5–139.7; P<0.0001), whereas there were no differences in laboratory and other polysomnographic findings. Conclusion: PLMs during REM sleep were not described in MS earlier, and they are associated with disability measured by the EDSS.
Role of Encryption in Cloud Data Warehousing: Trade-offs between security and performance in encrypted cloud data warehouses
Creators: name: Blessing, Elisha
name: K, Hubert
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 461302
subject: Computational complexity and computability
classificationCode: 460601
subject: Cloud computing

description: The increasing reliance on cloud data warehousing has necessitated a meticulous examination of the role of encryption in ensuring the security and performance of sensitive information. This study explores the intricate trade-offs that arise when implementing encryption measures in cloud data warehouses. The research delves into the definition and types of encryption, its applications across data at rest, in transit, and in use, and the complexities of key management. It highlights the risks associated with unencrypted data, emphasizing the critical need for robust security measures. On the flip side, the benefits of encryption, including confidentiality, integrity, and compliance, are underscored.
Aesthetic perception in Mikel Dufrenne's Phénoménologie de l'expérience esthétique : a phenomenological critique.
Creators: name: McMackon, Ian.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Philosophy.

description: I think that Mikel Dufrenne should be praised for his Phenomenologie de l'experience esthetique. The reason why I think this is that he attempts to describe aesthetic experience in terms which are wholly amenable to the experience of art itself from a phenomenological point of view. However, I believe that despite his attempts, Dufrenne ventures into an area which is not phenomenologically accessible, namely ontology. In general, it is the purpose of this thesis to show that Dufrenne's venture into the realm of ontology is beyond the phenomenologically given. And more so, that in attempting such a venture, Dufrenne neglects phenomenologically accessible data, namely, the acts which the spectator deploys when he confronts the aesthetic object. Specifically, it is the purpose of this thesis to show this neglect on Dufrenne's behalf by way of identifying the most simple acts contributed by the spectator. This thesis has three main divisions. The first two divisions are primarily expository, although not without criticism. The last division concretizes the criticism of the first two parts and shows my specific point of criticism regarding Dufrenne's text. In effect, the third part could be read as a supplement to Dufrenne's work itself. The first division consists in two chapters. The first chapter of this division is purely expository. It recounts Dufrenne's account of the a priori or the accord between man and world which grounds straightforward perception. The second chapter shows how the subjective moments of perception deploy themselves such that this accord is pregnant with, and capable of reading, meaning. There is, however, a critical overtone to the second chapter. This consists in noting that Dufrenne does not recognize the full extent in which the subject arrests and constitutes the meaning of straightforward perception. The second division consists in three chapters, all of which are expository and firmly delineate the subject matter as properly 'aesthetic'. For Dufrenne, aesthetic perception is demarcated from straightforward perception on the basis of objective as well as subjective content. With this in mind, this second part examines the a priori accord between spectator and aesthetic object, the nature of the aesthetic object itself, the subjective moments which realize its proper meaning, and the ontology by which (1) the aesthetic object has meaning and (2) this object is capable of expressing the reality of Being itself. The critical exposition makes clear that here, as in Dufrenne's notion of straightforward perception, there is a lack of attention paid to the subjective aspects of perception itself, or to say the same thing, the contribution on behalf of the subject by which he recognizes aesthetic meaning proper.