cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study
Creators: name: Chen, Songzan
name: Yang, Fangkun
name: Xu, Tian
name: Wang, Yao
name: Zhang, Kaijie
name: Fu, Guosheng
name: Zhang, Wenbin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 1: Figure S1. Funnel plot of the Mendelian randomization estimate for the association between serum 25-hydroxyvitamin D levels and the risk of CAD in patients with diabetes. Figure S2. Funnel plot of the Mendelian randomization estimate for the association between serum calcium levels and the risk of CAD in patients with diabetes. Figure S3. Funnel plot of the Mendelian randomization estimate for the association between serum parathyroid hormone levels and the risk of CAD in patients with diabetes. Figure S4. Leave-one-out analysis of the association between serum 25-hydroxyvitamin D levels and the risk of coronary artery disease in patients with diabetes. Figure S5. Leave-one-out analysis of the association between serum calcium levels and the risk of coronary artery disease in patients with diabetes. Figure S6. Leave-one-out analysis of the association between serum parathyroid hormone levels and the risk of coronary artery disease in patients with diabetes.
A distributed primal-dual algorithm for computation of generalized Nash equilibria with shared affine coupling constraints via operator splitting methods
Creators: name: Yi, Peng
name: Pavel, Lacra
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optimization and Control (math.OC)
subject: Computer Science and Game Theory (cs.GT)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we propose a distributed primal-dual algorithm for computation of a generalized Nash equilibrium (GNE) in noncooperative games over network systems. In the considered game, not only each player's local objective function depends on other players' decisions, but also the feasible decision sets of all the players are coupled together with a globally shared affine inequality constraint. Adopting the variational GNE, that is the solution of a variational inequality, as a refinement of GNE, we introduce a primal-dual algorithm that players can use to seek it in a distributed manner. Each player only needs to know its local objective function, local feasible set, and a local block of the affine constraint. Meanwhile, each player only needs to observe the decisions on which its local objective function explicitly depends through the interference graph and share information related to multipliers with its neighbors through a multiplier graph. Through a primal-dual analysis and an augmentation of variables, we reformulate the problem as finding the zeros of a sum of monotone operators. Our distributed primal-dual algorithm is based on forward-backward operator splitting methods. We prove its convergence to the variational GNE for fixed step-sizes under some mild assumptions. Then a distributed algorithm with inertia is also introduced and analyzed for variational GNE seeking. Finally, numerical simulations for network Cournot competition are given to illustrate the algorithm efficiency and performance.
description: 21 pages,8 figures, parts are submitted to IEEE CDC
Behaviour, temporal activity, and control of the red fox in the city
Creators: name: Fernández, Margarita Gil
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Foxes (Vulpes vulpes) are an invasive predator implicated in the decline and extinction of many Australian native species, and are thought to thrive better in urban than in natural areas. We investigated the behaviour of foxes towards a novel object (a control device – canid pest ejector), temporal activity, and interactions with potential prey and domestic predators, by comparing behaviour among site types and to several environmental variables. We assessed the risk of using this device via visitation by domestic dogs, and in relation to distance from human habitations. We used camera-traps in 16 sites around Sydney to record temporal activity, visitation, and behaviour of our study species. Our major finding was that foxes behaved more confidently in urban areas and under high vegetation cover than in sites within peri-urban areas and low vegetation cover. Foxes appeared slightly more nocturnal in urban areas, where they have a higher temporal activity overlap with introduced mammals, than in peri-urban areas. Only two non-canid species were recorded pulling-up the ejector, confirming its high target-specificity. The ejectors could be effective in urban areas as a method of control. They could be safely deployed in sites with effective dog restrictions, regardless of the distance from human habitation.
Additional file 3: of Abnormal placental cord insertion and adverse pregnancy outcomes: a systematic review and meta-analysis
Creators: name: Ismail, Khadijah
name: Hannigan, Ailish
name: OâDonoghue, Keelin
name: Cotter, Amanda
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology
subject: Science Policy

description: Table describing excluded studies. (DOCX 16Â kb)
Interactive Outlining of Pancreatic Cancer Liver Metastases in Ultrasound Images
Creators: name: Egger, Jan
name: Schmalstieg, Dieter
name: Chen, Xiaojun
name: Zoller, Wolfram G.
name: Hann, Alexander
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: Ultrasound (US) is the most commonly used liver imaging modality worldwide. Due to its low cost, it is increasingly used in the follow-up of cancer patients with metastases localized in the liver. In this contribution, we present the results of an interactive segmentation approach for liver metastases in US acquisitions. A (semi-) automatic segmentation is still very challenging because of the low image quality and the low contrast between the metastasis and the surrounding liver tissue. Thus, the state of the art in clinical practice is still manual measurement and outlining of the metastases in the US images. We tackle the problem by providing an interactive segmentation approach providing real-time feedback of the segmentation results. The approach has been evaluated with typical US acquisitions from the clinical routine, and the datasets consisted of pancreatic cancer metastases. Even for difficult cases, satisfying segmentations results could be achieved because of the interactive real-time behavior of the approach. In total, 40 clinical images have been evaluated with our method by comparing the results against manual ground truth segmentations. This evaluation yielded to an average Dice Score of 85% and an average Hausdorff Distance of 13 pixels.
description: 15 pages, 16 figures, 2 tables, 58 references
Collective mode contributions to the Meissner effect: Fulde-Ferrell and pair-density wave superfluids
Creators: name: Boyack, Rufus
name: Wu, Chien-Te
name: Anderson, Brandon M.
name: Levin, K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In this paper we demonstrate the necessity of including the generally omitted collective mode contributions in calculations of the Meissner effect for non-uniform superconductors. We consider superconducting pairing with non-zero center of mass momentum, as is relevant to high transition temperature cuprates, cold atoms, and quantum chromodynamic superconductors. For the concrete example of the Fulde-Ferrell phase we present a quantitative calculation of the superfluid density, showing the collective mode contributions are not only appreciable but that they derive from the amplitude mode of the order parameter. This latter mode (related to the Higgs mode in a charged system) is generally viewed as being invisible in conventional superconductors. However, our analysis shows that it is extremely important in pair-density wave type superconductors, where it destroys superfluidity well before the mean-field order parameter vanishes.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Cart. 187 (11 H 72), f. 0047v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0047v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0047v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Targeting Androgen Receptor Pathways in Ovarian Cancer: A Review of Current Advances and Future Directions
Creators: name: Makedonskaia, Sofiia
Publisher: name: Zenodo
Year: 2024

description: Ovarian cancer, particularly epithelial ovarian carcinoma (EOC), is a complex disease where androgen receptor (AR)-mediated signaling plays a crucial role in progression and treatment. Despite promising preclinical data, clinical trials with anti-androgens have yielded disappointing results. This review discusses current advances and future directions in targeting AR pathways in ovarian cancer, including AR's role in cellular proliferation, survival, and signal transduction. Challenges, such as resistance mechanisms and lack of clinical efficacy, are addressed, and potential therapeutic strategies, including combination therapies and adaptive therapy, are proposed. The complexity of AR-mediated pathways and their interactions with other signaling mechanisms highlight the need for further research to improve clinical outcomes for ovarian cancer patients.
Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines
Creators: name: Becker, Jennifer
name: Kinast, Volker
name: Döring, Marius
name: Lipps, Christoph
name: Duran, Veronica
name: Spanier, Julia
name: Tegtmeyer, Pia-Katharina
name: Wirth, Dagmar
name: Cicin-Sain, Luka
name: Alcamí, Antonio
name: Kalinke, Ulrich
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Infection of healthy individuals with human cytomegalovirus (HCMV) is usually unnoticed and results in life-long latency, whereas HCMV reactivation as well as infection of newborns or immunocompromised patients can cause life-threatening disease. To better understand HCMV pathogenesis we studied mechanisms that restrict HCMV spread. We discovered that HCMV-infected cells can directly trigger plasmacytoid dendritic cells (pDC) to mount antiviral type I interferon (IFN-I) responses, even in the absence of cell-free virus. In contrast, monocyte-derived cells only expressed IFN-I when stimulated by cell-free HCMV, or upon encounter of HCMV-infected cells that already produced cell-free virus. Nevertheless, also in the absence of cell-free virus, i.e., upon co-culture of infected epithelial/endothelial cells and monocyte-derived macrophages (moMΦ) or dendritic cells (moDC), antiviral responses were induced that limited HCMV spread. The induction of this antiviral effect was dependent on cell-cell contact, whereas cell-free supernatants from co-culture experiments also inhibited virus spread, implying that soluble factors were critically needed. Interestingly, the antiviral effect was independent of IFN-γ, TNF-α, and IFN-I as indicated by cytokine inhibition experiments using neutralizing antibodies or the vaccinia virus-derived soluble IFN-I binding protein B18R, which traps human IFN-α and IFN-β. In conclusion, our results indicate that human macrophages and dendritic cells can limit HCMV spread by IFN-I dependent as well as independent mechanisms, whereas the latter ones might be particularly relevant for the restriction of HCMV transmission via cell-to-cell spread.
Additional file 11: Figure S9. of A reconstruction of sexual modes throughout animal evolution
Creators: name: Sasson, Daniel
name: Ryan, Joseph
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Transitions across the stochastic character mapping ancestral state reconstruction of the â ctenophore-sisterâ topology averaged over 1000 simulations. Blue represents separate sexes, red hermaphroditism, and yellow asexuality. Gradations between those colors indicate areas where transitions were simulated to have occurred. R script used to generate this PDF is available here: https://github.com/josephryan/2017b_Sasson_and_Ryan . (PDF 64 kb)
Chaotic Lagrangian models for turbulent relative dispersion
Creators: name: Lacorata, Guglielmo
name: Vulpiani, Angelo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: A deterministic multi-scale dynamical system is introduced and discussed as prototype model for relative dispersion in stationary, homogeneous and isotropic turbulence. Unlike stochastic diffusion models, here trajectory transport and mixing properties are entirely controlled by Lagrangian Chaos. The anomalous "sweeping effect", a known drawback common to kinematic simulations, is removed thanks to the use of quasi-Lagrangian coordinates. Lagrangian dispersion statistics of the model are accurately analysed by computing the Finite-Scale Lyapunov Exponent (FSLE), which is the optimal measure of the scaling properties of dispersion. FSLE scaling exponents provide a severe test to decide whether model simulations are in agreement with theoretical expectations and/or observation. The results of our numerical experiments cover a wide range of "Reynolds numbers" and show that chaotic deterministic flows can be very efficient, and numerically low-cost, models of turbulent trajectories in stationary, homogeneous and isotropic conditions. The mathematics of the model is relatively simple and, in a geophysical context, potential applications may regard small-scale parametrization issues in general circulation models, mixed layer and/or boundary layer turbulence models as well as Lagrangian predictability studies.
description: 22 pages, 5 figures
Katabasis in ekphrasis poetry: a study of memory, rhetoric and mind
Creators: name: Papas, Diana Marietta
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Over the last few decades, modern definitions of ekphrasis are typically limited to the verbal description of a visual work of art (real or imagined). Rarely is modern ekphrasis contextualised in the ancient rhetorical tradition as a function of mind, memory and imagination. This thesis—which focuses specifically on the literary genre of ekphrasis poetry—aims to illuminate ekphrasis strategies as articulations of memory and the function of imagination. Given the close associations of imagination with creativity, the function of imagination has become a rapidly growing area of research in cognitive literary studies. The thesis addresses imagination in terms of mental imaging (the formation of visual and other kinds of sensory images), and the recent research into the brain’s default mode network which relates imagination to memory, conceptual blending, prospection, mind wandering and navigation. The thesis explores the ancient literary genre of katabasis—typically defined as a journey of the living into the realm of the dead, underworld or place of psychic unconscious. Katabasis is also characterised as a descent into memory, involving a trial, confrontation and subsequent ascent into knowing or “seeing”. Using an interdisciplinary approach, the thesis reveals the rhetorical devices of katabasis and ekphrasis in poetry which share common strategies with cognitive theories on the function of imagination. A selection of poems written by Adrienne Rich and Seamus Heaney are examined for their techniques of ekphrasis and exploration of katabasis. The thesis aims to reframe the function of mind, memory and imagination—key to classical and medieval conceptions of ekphrasis and katabasis—into modern and contemporary ekphrasis criticism.
FN-2HDM: Two Higgs Doublet Models with Froggatt-Nielsen Symmetry
Creators: name: Dery, Avital
name: Nir, Yosef
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We embed Two Higgs Doublet Models (2HDMs) in the Froggatt Nielsen (FN) framework. We find that the approximate FN symmetry predicts i) approximate Natural Flavor Conservation (NFC) of Types II or IV in the Yukawa sector, and ii) approximate Peccei-Quinn (PQ) symmetry in the scalar sector. We discuss the phenomenological consequences of these features.
Additional file 7: Table S7. of Low serum sodium concentration is a prognostic factor related to current blood glucose level in stable hemodialysis patients: an observational study
Creators: name: Nagai, Kojiro
name: Ueda, Sayo
name: Tsuchida, Kenji
name: Doi, Toshio
name: Minakuchi, Jun
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Demographic and clinical characteristics of low sodium or high sodium stable middle-aged patients. (PDF 130Â kb)
Helicobacter pylori SabA binding gangliosides of human stomach
Creators: name: Benktander, John
name: Barone, Angela
name: Johansson, Miralda Madar
name: Teneberg, Susann
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Adhesion of Helicobacter pylori to the gastric mucosa is a prerequisite for the pathogenesis of H. pylori related diseases. In this study, we investigated the ganglioside composition of human stomach as the target for attachment mediated by H. pylori SabA (sialic acid binding adhesin). Acid glycosphingolipids were isolated from human stomach and separated into subfractions, which were characterized by mass spectrometry and by binding of antibodies, bacteria, and Solanum tuberosum lectin. H. pylori SabA binding gangliosides were characterized as Neu5Acα3-neolactohexaosylceramide and Neu5Acα3-neolactooctaosylceramide, while the other acid human stomach glycosphingolipids characterized (sulfatide and the gangliosides GM3, GD3, GM1, Neu5Acα3-neolactotetraosylceramide, GD1a and GD1b) were not recognized by the bacteria. Defining H. pylori binding glycosphingolipids of the human gastric mucosa will be useful to specifically target this microbe-host interaction for therapeutic intervention.
Spin-dependent thermoelectric effects in a strongly correlated double quantum dot
Creators: name: Karwacki, Łukasz
name: Trocha, Piotr
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate spin-dependent thermoelectric transport through a system of two coupled quantum dots attached to reservoirs of spin-polarized electrons. Generally, we focus on the strongly correlated regime of transport. To this end, a slave-boson method for finite $U$ is employed. Our main goal is to show that, apart from complex low-temperature physics, such a basic multilevel system provides a possibility to examine various quantum interference effects, with particular emphasis put on the influence of such phenomena on thermoelectric transport. Apart from the influence of interference effects on spin-degenerate charge transport, we show how spin-dependent transport, induced by ferromagnetic leads, can be modified as well. Finally, we also consider the case where the spin-relaxation time in the ferromagnetic leads is relatively long, which leads to the so-called spin thermoelectric effects.
description: 14 pages, 13 figures
Effect of board diversity on firm performance in different social contexts: evidence from Vietnam and Australia
Creators: name: Nam The Nguyen
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The business case for board diversity is contrasted in two different social contexts in this thesis. Specifically, the effect of differences in gender, ethnicity, and the age of the directors may have on firm financial performance is compared across a sample of Vietnamese and Australian listed companies. The research employs the most efficient panel data regression method using a selection procedure of fixed/random effects testing. Regression output indicates that the gender and ethnic diversity of the board more positively influences Tobin’s Q in Vietnam than they do in Australia while age diversity does not. Additionally, ethnic diversity more positively influences return on assets in Vietnam than in Australia, whereas age diversity more positively affects return on assets in Australia than in Vietnam. The result also suggests that there is no difference in the impact of gender diversity on return on assets across the two nations. These findings will have important implications for global harmonisation, the convergence of corporate governance, in general, and, in particular, recommendations about board diversity.
Value of quantitative and qualitative analyses of serum and urine cell-free DNA as diagnostic tools for bladder cancer: a meta-analysis
Creators: name: Cao, Zhangjun
name: Peng, Longfei
name: He, Ke
name: Wang, Xin
name: Lu, Youlu
name: Zhang, Ying
name: Bi, Liangkuan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Background: Qualitative and quantitative analysis of circulating cell-free DNA (cfDNA) is a potential detection method for bladder cancer. Many studies have focused on the reliability of these results, but the conclusions have not been consistent. Methods: We performed a diagnostic meta-analysis to investigate the diagnostic significance of serum and urine cfDNAs with tumor tissues as the standard control. We searched the MEDLINE, EMABASE, and Cochrane Central Controlled Trials Register (CCTR) databases until January 2019. Results: A total of 11 studies involving early and/or advanced bladder cancer were finally included. The overall diagnostic accuracy was measured as follows: pooled sensitivity and specifcity were 0.69 (95%CI: 0.67, 0.71) and 0.72 (95%CI: 0.70, 0.74). Pooled positive likelihood ratio and negative likelihood ratio were 3.10 (95%CI: 2.35, 4.07) and 0.41 (95%CI: 0.34, 0.49). Combined diagnostic odds ratio was 8.26 (95%CI: 5.64, 12.11). A high diagnostic accuracy was demonstrated by the summary receiver operating characteristic curve, with area under the curve of 0.80 (95%CI: 0.77, 0.83). Conclusions: CfDNA assay has high diagnostic value for the detection of bladder cancer. Larger sample studies are needed to further confirm our conclusions and to make this approach more sensitive and specific.
title: ADCO, Grènetier de Cîteaux : comptes (1499-1503) (11 H 1173), f. 00103
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173), f. 00103, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
The determination of the Dzyaloshinskii-Moriya interaction in exchange biased Au/Co/NiO system
Creators: name: Kuświk, Piotr
name: Matczak, Michał
name: Kowacz, Mateusz
name: Lisiecki, Filip
name: Stobiecki, Feliks
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences
subject: 82D40

description: The determination of the interfacial Dzyaloshinskii-Moriya interaction for perpendicularly magnetized thin layered films is not trivial and therefore needs some experimental efforts to determine its sign and magnitude, especially in the exchange biased system. Here, we developed a method proposed by D.-S. Han et al. [Nano Lett. 16, (2016) 4438], which opens a way to investigate this interaction using a conventional PMOKE magnetometer, also in exchange biased systems. Using our approach we demonstrated that the Au/Co/NiO layered system has a strong negative Dzyaloshinskii-Moriya interaction, which is independent of the direction of perpendicular interlayer exchange bias coupling.
description: 10 pages, 4 figures
Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors
Creators: name: Gao, Jie
name: Xin, Wenwen
name: Huang, Jing
name: Ji, Bin
name: Gao, Shan
name: Chen, Liang
name: Kang, Lin
name: Yang, Hao
name: Shen, Xin
name: Zhao, Baohua
name: Wang, Jinglin
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced hemolysis has not previously been reported. In this study, the hemolytic ability of ETX was examined using erythrocytes from 10 species including murine, rabbit, sheep, monkey and human. We found that ETX caused hemolysis in human erythrocytes (HC50 = 0.2 μM) but not erythrocytes from the other test species. Moreover, the mechanism of ETX-induced hemolysis was further explored. Recent studies showed that some bacterial toxins induce hemolysis through purinergic receptor (P2) activation. Hence, the function of purinergic receptors in ETX-induced hemolysis was tested, and we found that the non-selective P2 receptor antagonists PPADS inhibited ETX-induced lysis of human erythrocytes in a concentration-dependent manner, indicating that ETX-induced hemolysis requires activation of purinergic receptors. P2 receptors comprise seven P2X (P2X1–7) and eight P2Y (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11–P2Y14) receptor subtypes. The pattern of responsiveness to more selective P2-antagonists implies that both P2Y13 and P2X7 receptors are involved in ETX-induced hemolysis in human species. Furthermore, we demonstrated that extracellular ATP is likely not involved in ETX-induced hemolysis and the activation of P2 receptors. These findings clarified the mechanism of ETX-induced hemolysis and provided new insight into the activities and ETX mode of action.
Interaction effects of substrate fermentation and larval density on black soldier fly life-history traits
Creators: name: Opare, L.O.
name: Holm, S.
name: Esperk, T.
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 309999
subject: Other agricultural, veterinary and food sciences not elsewhere classified

description: Agricultural by-products can serve as an excellent food source for edible insects, but their high-fibre properties can present challenges. One solution to this is fermentation, which can enhance their nutritional value by breaking down the fibre. However, little research has been conducted on how this method interacts with other environmental factors in insect rearing. To address this gap, our study aimed to investigate the impact of substrate fermentation and larval density on black soldier fly (BSF) larvae. We compared fermented substrates (fermented spent grain and additionally fermented ensiled grass) with standard fibrous substrates (spent grain and ensiled grass) and applied two larval density treatments (high and low). Our findings revealed that prepupal mass was significantly greater in fermented substrates than in standard fibrous substrates, with variations dependent on the substrate and larval density treatments. Larval density significantly influenced prepupal mass only in the fermented spent grain treatment. Substrate type influenced development time, with fermented spent grain resulting in a shorter development time than ensiled grass. However, substrate fermentation and larval density did not affect development time. Substrate fermentation only increased larval survival when individuals were reared on spent grain at high larval density. There were no significant differences in survival between fermented and standard substrates in other substrate and larval density combinations. Our study demonstrates that fermentation could serve as a way to amend fibrous substrates, making them suitable for rearing BSF larvae; however, its effects depend on environmental factors such as larval density.
The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses
Creators: name: Chang, Peixi
name: Li, Weitian
name: Shi, Guolin
name: Li, Huan
name: Yang, Xiaoqing
name: Xia, Zechen
name: Ren, Yuan
name: Li, Zhiwei
name: Chen, Huanchun
name: Bei, Weicheng
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Streptococcus suis is a highly invasive pathogen that can cause sepsis and meningitis in pigs and humans. However, we have limited understanding of the mechanisms S. suis uses to evade innate immunity. To investigate the involvement of the two-component signal transduction system of S. suis in host immune defense, we examined the expression of 15 response regulators of S. suis following stimulation with polymorphonuclear leukocytes (PMNs). We found that several response regulators were significantly up-regulated including vraR. Thus, we constructed an isogenic deletion mutant of vraSR genes in S. suis and demonstrated VraSR promotes both bacterial survival in human blood and resistance to human PMN-mediated killing. The VraSR mutant was more susceptible to phagocytosis by human PMNs and had greater sensitivity to oxidant and lysozyme than wild-type S. suis. Furthermore, in vitro findings and in vivo evidence from a mouse infection model together strongly demonstrate that ΔvraSR had greatly attenuated virulence compared with wild-type S. suis. Collectively, our data reveal that VraSR is a critical regulatory system that contributes to the survival of S. suis and its ability to defend against host innate immunity.
Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts
Creators: name: Duan, Zhiqiang
name: Xu, Haixu
name: Ji, Xinqin
name: Zhao, Jiafu
name: Xu, Houqiang
name: Hu, Yan
name: Deng, Shanshan
name: Hu, Shunlin
name: Liu, Xiufan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Virology

description: The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear localization in the replication and pathogenicity of NDV remain unclear. In this study, importin β1 was screened to interact with NDV M protein by yeast two-hybrid screening. This interaction was subsequently confirmed by co-immunoprecipitation and pull-down assays. In vitro binding studies indicated that the NLS region of M protein and the amino acids 336–433 of importin β1 that belonged to the RanGTP binding region were important for binding. Importantly, a recombinant virus with M/NLS mutation resulted in a pathotype change of NDV and attenuated viral replication and pathogenicity in chicken fibroblasts and SPF chickens. In agreement with the binding data, nuclear import of NDV M protein in digitonin-permeabilized HeLa cells required both importin β1 and RanGTP. Interestingly, importin α5 was verified to interact with M protein through binding importin β1. However, importin β1 or importin α5 depletion by siRNA resulted in different results, which showed the obviously cytoplasmic or nuclear accumulation of M protein and the remarkably decreased or increased replication ability and pathogenicity of NDV in chicken fibroblasts, respectively. Our findings therefore demonstrate for the first time the nuclear import mechanism of NDV M protein and the negative regulation role of importin α5 in importin β1-mediated nuclear import of M protein and the replication and pathogenicity of a paramyxovirus.
Restoration of autophagy activity by dipsacoside B alleviates exhaustive exercise-induced kidney injury via the AMPK/mTOR pathway
Creators: name: Li, Zhenyu
name: Tian, Zhuang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Exhaustive exercise (EE) induces kidney injury, but its concrete mechanism has not been fully elucidated. Hepatoprotective effects of dipsacoside B (DB) have been found previously, involving in autophagy induction. However, whether DB exerts renal protective effect and its potential mechanism are still unknown. The present study aimed to investigate the benefit of DB in EE-induced kidney injury and decipher its underlying mechanism. Here, we found that DB ameliorated EE-induced renal dysfunction and renal histopathological injury in rats. DB possessed anti-inflammatory, anti-oxidative, and anti-apoptotic functions in kidneys of exercise-induced exhausted rats. Besides, DB improved autophagy function in kidneys of EE rats. Mechanically, activation of the adenylate-activating protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway was implicated in the kidney injury-relieving effects and autophagy restoration induced by DB. Collectively, these findings provide reference for the clinical application of DB in preventing and managing EE-induced kidney injury.
Induction of the pneumococcal vncRS operon by lactoferrin is essential for pneumonia
Creators: name: Lee, Seungyeop
name: Ghosh, Prachetash
name: Kwon, Hyogyoung
name: Park, Sang-Sang
name: Kim, Gyu-Lee
name: Choi, Sang-Yoon
name: Kim, Eun-Hye
name: Tran, Thao Dang-Hien
name: Seon, Seung Han
name: Le, Nhat Tu
name: Iqbal, Hamid
name: Lee, Sangho
name: Pyo, Suhkneung
name: Rhee, Dong-Kwon
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Evolutionary Biology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Streptococcus pneumoniae (pneumococcus), the major pathogen for pneumonia, commonly colonizes the lung, but the mechanism underlying the coordination of virulence factors during invasion via the host protein remains poorly understood. Bacterial lysis releases the components of the cell wall, and triggers innate immunity and the subsequent secretion of pro-inflammatory cytokines. Previously, the virulence of the pep27 mutant was shown to be attenuated as a feasible candidate for vaccine development. However, the role of pep27 gene, belonging to the vancomycin-resistance locus (vncRS operon), in virulence, is largely unknown. This study demonstrates that transferrin in the host serum reduces the survival of the host during S. pneumoniae infections in mice. The exposure of the pneumococcal D39 strain to lactoferrin induced the vncRS operon, lysis, and subsequent in vivo cytokine production, resulting in lung inflammation. However, these responses were significantly attenuated in pneumococci harboring a mutation in pep27. Mechanistically, the VncS ligand, identified as lactoferrin, induced the vncRS operon and increased the in vivo mortality rates. Thus, serum-induced activation of vncRS plays an essential role in inducing pneumonia.
Searching for the expelled hydrogen envelope in Type I supernovae via late-time H-alpha emission
Creators: name: Vinko, J.
name: Pooley, D.
name: Silverman, J. M.
name: Wheeler, J. C.
name: Szalai, T.
name: Kelly, P.
name: MacQueen, P.
name: Marion, G. H.
name: Sarneczky, K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report the first results from our long-term observational survey aimed at discovering late-time interaction between the ejecta of hydrogen-poor Type I supernovae and the hydrogen-rich envelope expelled from the progenitor star several decades/centuries before explosion. The expelled envelope, moving with a velocity of ~10 -- 100 km s$^{-1}$, is expected to be caught up by the fast-moving SN ejecta several years/decades after explosion depending on the history of the mass-loss process acting in the progenitor star prior to explosion. The collision between the SN ejecta and the circumstellar envelope results in net emission in the Balmer-lines, especially in H-alpha. We look for signs of late-time H-alpha emission in older Type Ia/Ibc/IIb SNe having hydrogen-poor ejecta, via narrow-band imaging. Continuum-subtracted H-alpha emission has been detected for 13 point sources: 9 SN Ibc, 1 SN IIb and 3 SN Ia events. Thirty-eight SN sites were observed on at least two epochs, from which three objects (SN 1985F, SN 2005kl, SN 2012fh) showed significant temporal variation in the strength of their H-alpha emission in our DIAFI data. This suggests that the variable emission is probably not due to nearby H II regions unassociated with the SN, and hence is an important additional hint that ejecta-CSM interaction may take place in these systems. Moreover, we successfully detected the late-time H-alpha emission from the Type Ib SN 2014C, which was recently discovered as a strongly interacting SN in various (radio, infrared, optical and X-ray) bands.
description: 8 pages, 7 figures, accepted in ApJ
Hyperbolic inflation in the Jordan frame
Creators: name: Paliathanasis, Andronikos
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider a multi-scalar field model in the Jordan frame which can be seen as a two-scalar field model where the Brans-Dicke field interacts in the kinetic part with the second scalar field. This theory under a conformal transformation reduces to the hyperbolic inflation. We show that scaling solutions and the de Sitter universe are provided by theory. In the study of asymptotic dynamics, we determine an attractor where all the fluid sources contribute in the cosmological fluid. This attractor is always a spiral and it can be seen as the analogue of the hyperbolic inflation in the Jordan frame.
description: 16 pages, 3 figures
MOESM1 of Lipid-rafts remain stable even after ionizing radiation induced disintegration of Î˛1 integrin containing focal adhesions
Creators: name: Babel, Laura
name: Kruse, Larissa
name: Bump, Steven
name: Langhans, Markus
name: Meckel, Tobias
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Additional file 1. Additional information. Details of experimental procedure and Additional figures S1, S2 and S3.
BYUDJET TASHKILOTLARIDA MOLIYAVIY NATIJALAR HISOBINI TASHKIL ETISHNI TAKOMILLASHTIRISH
Creators: name: Achilov, Uyg'unjon
name: Sapayev, Jahongir
Publisher: name: Zenodo
Year: 2024

description: Maqolada O’zbekistonda jahon mamlakatlari tajribalari asosida byudjet tashkilotlarining moliyaviy natijalar hisobini tashkil etish va takomillashtirish  yo’llari atroflicha tahlil qilingan. Byudjet tashkilotlarida moliyabviy natijalar hisobining o’ziga xos xususiyatlari aniqlangan hamda tegishli xulosa berilgan va tavsiyalar ishlab chiqilgan.
PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target
Creators: name: Yin, Yuebang
name: Dang, Wen
name: Zhou, Xinying
name: Xu, Lei
name: Wang, Wenshi
name: Cao, Wanlu
name: Chen, Sunrui
name: Su, Junhong
name: Cai, Xuepeng
name: Xiao, Shaobo
name: Peppelenbosch, Maikel P.
name: Pan, Qiuwei
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is an important complement that cannot be substituted. Because of the lack of specific approved treatment, it is urgent to facilitate the cascade of further understanding of the infection biology, identification of druggable targets and the final development of effective antiviral therapies. PI3K-Akt-mTOR signaling pathway plays a vital role in regulating the infection course of many viruses. In this study, we have dissected the effects of PI3K-Akt-mTOR signaling pathway on rotavirus infection using both conventional cell culture models and a 3D model of human primary intestinal organoids. We found that PI3K-Akt-mTOR signaling is essential in sustaining rotavirus infection. Thus, blocking the key elements of this pathway, including PI3K, mTOR and 4E-BP1, has resulted in potent anti-rotavirus activity. Importantly, a clinically used mTOR inhibitor, rapamycin, potently inhibited both experimental and patient-derived rotavirus strains. This effect involves 4E-BP1 mediated induction of autophagy, which in turn exerts anti-rotavirus effects. These results revealed new insights on rotavirus-host interactions and provided new avenues for antiviral drug development.