cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficient CSL Model Checking Using Stratification
Creators: name: Zhang, Lijun
name: Jansen, David N.
name: Nielson, Flemming
name: Hermanns, Holger
Publisher: name: arXiv
Year: 2011
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: G.3, F.4.1, F.3.1

description: For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996. Their proof can be turned into an approximation algorithm with worse than exponential complexity. In 2000, Baier, Haverkort, Hermanns and Katoen presented an efficient polynomial-time approximation algorithm for the sublogic in which only binary until is allowed. In this paper, we propose such an efficient polynomial-time approximation algorithm for full CSL. The key to our method is the notion of stratified CTMCs with respect to the CSL property to be checked. On a stratified CTMC, the probability to satisfy a CSL path formula can be approximated by a transient analysis in polynomial time (using uniformization). We present a measure-preserving, linear-time and -space transformation of any CTMC into an equivalent, stratified one. This makes the present work the centerpiece of a broadly applicable full CSL model checker. Recently, the decision algorithm by Aziz et al. was shown to work only for stratified CTMCs. As an additional contribution, our measure-preserving transformation can be used to ensure the decidability for general CTMCs.
description: 18 pages, preprint for LMCS. An extended abstract appeared in ICALP 2011
Coping with heat : community perceptions and experiences of urban forests in Metro Vancouver, Canada
Creators: name: Stevens, Kirsten Marie
Publisher: name: University of British Columbia
Year: 2022

description: During the 2021 Western North America heat wave, British Columbians experienced unprecedented temperatures and heat-related illnesses and deaths. As more extreme temperatures are anticipated in the future, it is vital to find ways to alleviate urban heat. Urban forests can reduce temperatures via shading and evapotranspiration, thereby contributing to climate resilience and mitigating heat-related health impacts. However, it is not well understood how residents’ preferences and social, economic, and environmental factors impact their use of urban forests to cope with heat. This limits the capacity of municipalities to design urban forests that meet the heat resilience needs of diverse populations. My research contributes to this field of inquiry by (1) presenting a literature review of the emerging intersections between urban forestry, environmental justice, public health, and heat resilience, and (2) exploring how heat vulnerability status and certain environments/activities (i.e., being at home versus participating in recreation outdoors) influence thermal comfort, cooling method use, and perceptions of street tree protection from heat in Metro Vancouver, Canada. In addition, I situate the diverse perceptions and experiences uncovered by my analyses to inform how urban forestry policy can help mitigate, not exacerbate, existing health and environmental inequities. Findings from the narrative literature review highlight the need for cross-disciplinary collaboration between urban forestry and public health policy makers for heat resilience, with a focus on integrating community perspectives into future planning efforts. My findings suggest that trees are an efficient, potentially equitable way to provide heat relief. However, trees cannot solve everything; they are part of a context-dependent, integrated city heat resilience plan that prioritizes environmental and health equity for heat-vulnerable people and neighborhoods.
Identifying novel and potent inhibitors of EGFR protein for the drug development against the breast cancer
Creators: name: Siddiqui, Arif Jamal
name: Jahan, Sadaf
name: Patel, Mitesh
name: Abdelgadir, Abdelmushin
name: Alturaiki, Wael
name: Bardakci, Fevzi
name: Sachidanandan, Manojkumar
name: Badraoui, Riadh
name: Snoussi, Mejdi
name: Adnan, Mohd
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The epidermal growth factor receptor (EGFR) has been shown to be extremely important in numerous signaling pathways, particularly those involved in cancer progression. Many therapeutic inhibitors, consisting of both small molecules and monoclonal antibodies, have been developed to target inflammatory, triple-negative and metastatic breast cancer. With the emergence of resistance in breast cancer treatment strategies, there is a need to develop novel drug targets that not only overcome resistance, but also exhibit low toxicity and high specificity. The work presented here focuses on the identification of new inhibitors against the EGFR protein using combined computational approaches. Using a comprehensive machine learning-based virtual screening approach complemented by other computational approaches, we identified six new molecules from the ZINC database. The gold docking score of these six novel molecules is 125.95, 125.38, 123.13, 119.71, 115.64 and 113.73, respectively, while the gold score of the control group is 120.74. In addition, we also analyzed the FEC value of these compounds and found that the values of compounds 1, 2, 3 and 4 (−61.82, −63.98, −67.98 and −63.32, respectively) were higher are than those of the control group (−61.05). Furthermore, these molecules showed highly stable RMSD plots and good interaction of hydrogen bonds. The identified inhibitors provided interesting insights for understanding the electronic, hydrophobic, steric and structural requirements for EGFR inhibitory activity. Distinguishing these novel molecules could lead to the development of new drugs useful in treating breast cancer. Communicated by Ramaswamy H. Sarma
International Trade and Economic Growth
Creators: name: Mackie, Arthur B.
name: Mackie, Arthur B.
Publisher: name: Unknown
Year: 1964
Subjects: International Development
International Relations/Trade
Research Methods/ Statistical Methods

description: Excerpts from the report: As the world's largest trading country, the United States is vitally interested in the prospects of increased trade potentials growing out of sustained economic growth in foreign countries. Since foreign economic growth and trade expansion may be major factors affecting continued economic growth in the United States, it is vitally important that more knowledge be gained about the interrelationships of foreign economic growth, international trade, and market potentials for U.S. farm products. The objective of this paper is to examine the basic relationships between economic growth and trade as a basis for evaluating the effects of increased incomes in foreign countries on trade with the United States. More specifically, trade and income data will be examined for different groups of countries at different stages of development for 1959 and 1960 as a basis for evaluating market potentials for U.S. agricultural products with continued economic growth abroad. These 2 years were chosen for a cross-sectional analysis of income and trade data since these years seem indicative of future economic conditions at home and abroad. In addition, more income and trade data were available for more countries for these years than for later years.
description: Reprinted from Foreign Agricultural Trade of the United States February-March 1964
Scattering, homogenization and interface effects for oscillatory potentials with strong singularities
Creators: name: Duchêne, Vincent
name: Weinstein, Michael I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 35J10, 35P25, 35B40, 35B27

description: We study one-dimensional scattering for a decaying potential with rapid periodic oscillations and strong localized singularities. In particular, we consider the Schrödinger equation \[ H_εψ:= (-\partial_x^2 + V_0(x) + q(x,x/ε)) ψ= k^2 ψ, \] for $k\in\RR$ and $ε<< 1$. Here, $q(.,y+1)=q(.,y)$, has mean zero and $|V_0(x)+q(x,.)|$ goes to zero as $|x|$ goes to infinity. The distorted plane waves of $H_ε$ are solutions of the form: $e^{\pm ikx}+u^s_\pm(x;k)$, $u^s_\pm$ outgoing as $|x|$ goes to infinity. We derive their $ε$ small asymptotic behavior, from which the asymptotic behavior of scattering quantities such as the transmission coefficient, $t^ε(k)$, follow. Let $t_0^{hom}(k)$ denote the homogenized transmission coefficient associated with the average potential $V_0$. If the potential is smooth, then classical homogenization theory gives asymptotic expansions of, for example, distorted plane waves, and transmission and reflection coefficients. Singularities of $V_0$ or discontinuities of $q_ε$, that our theory admits, are "interfaces" across which a solution must satisfy interface conditions (continuity or jump conditions). To satisfy these conditions it is necessary to introduce interface correctors, which are highly oscillatory in $ε$. A consequence of our main results is that $t^ε(k)-t_0^{hom}(k)$, the error in the homogenized transmission coefficient is (i) $O(ε^2)$ if $q_ε$ is continuous and (ii) $O(ε)$ if $q_ε$ has discontinuities. Moreover, in the discontinuous case the correctors are highly oscillatory in $ε$, so that a first order corrector is not well-defined. The analysis is based on a (pre-conditioned) Lippman-Schwinger equation, introduced in [SIAM J. Mult. Mod. Sim. (3), 3 (2005), pp. 477--521].
description: To appear in SIAM Multiscale Modeling, Analysis and Simulation (2011)
Dynamics of geometric and entropic quantifiers of correlations in open quantum systems
Creators: name: Bellomo, Bruno
name: Franco, Rosario Lo
name: Compagno, Giuseppe
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We extend the Hilbert-Schmidt (square norm) distance, previously used to define the geometric quantum discord, to define also geometric quantifiers of total and classical correlations. We then compare the dynamics of geometric and entropic quantifiers of the different kinds of correlations in a non-Markovian open two-qubit system under local dephasing. We find that qualitative differences occur only for quantum discords. This is taken to imply that geometric and entropic discords are not, in general, equivalent in describing the dynamics of quantum correlations. We then show that also geometric and entropic quantifiers of total correlations present qualitative disagreements in the state space. This aspect indicates that the differences found for quantum discord are not attributable to a different separation, introduced by each measure, between the quantum and classical parts of correlations. Finally, we find that the Hilbert-Schmidt distance formally coincides with a symmetrized form of linear relative entropy.
description: 7 pages, 4 figures. Final modified version accepted for publication in Phys. Rev. A
Identification of potential novel inhibitors against glutamine synthetase enzyme of Leishmania major by using computational tools
Creators: name: Kashif, Mohammad
name: Subbarao, Naidu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Glutamine Synthetase (GS) is functionally important in many pathogens, so its viability as a drug target has been widely investigated. We identified Leishmania major glutamine synthetase (Lm-GS) as an appealing target for developing potential leishmaniasis inhibitors. Comparative modeling, virtual screening, MD simulations along with MM-PBSA analyses were performed and two FDA approved compounds namely Chlortalidone (id ZINC00020253) and Ciprofloxacin (id ZINC00020220) were identified as potential inhibitor among the screened library. These compounds may be used as a lead molecule, although additional in vitro and in vivo testing is required to establish its anti-leishmanial effect. Hence, the goal of this study was to locate and identify certain medications that were previously FDA-approved for definite disorders and that might show anti-leishmanial effect. Due to GS's presence in additional Leishmania species, a novel medication docked with Lm-GS may have broad anti-leishmania efficacy. Communicated by Ramaswamy H. Sarma
Bounds on positive operator-valued measure based coherence of superposition
Creators: name: Guo, Meng-Li
name: Liang, Jin-Min
name: Li, Bo
name: Fei, Shao-Ming
name: Wang, Zhi-Xi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum coherence is a fundamental feature of quantum physics and plays a significant role in quantum information processing. By generalizing the resource theory of coherence from von Neumann measurements to positive operator-valued measures (POVMs), POVM-based coherence measures have been proposed with respect to the relative entropy of coherence, the $l_1$ norm of coherence, the robustness of coherence and the Tsallis relative entropy of coherence. We derive analytically the lower and upper bounds on these POVM-based coherence of an arbitrary given superposed pure state in terms of the POVM-based coherence of the states in superposition. Our results can be used to estimate range of quantum coherence of superposed states. Detailed examples are presented to verify our analytical bounds.
description: 15 pages, 2 figures
A data-driven rutting depth short-time prediction model with metaheuristic optimization for asphalt pavements based on RIOHTrack
Creators: name: Li, Zhuoxuan
name: Korovin, Iakov
name: Shi, Xinli
name: Gorbachev, Sergey
name: Gorbacheva, Nadezhda
name: Huang, Wei
name: Cao, Jinde
Publisher: name: arXiv
Year: 2023
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Rutting of asphalt pavements is a crucial design criterion in various pavement design guides. A good road transportation base can provide security for the transportation of oil and gas in road transportation. This study attempts to develop a robust artificial intelligence model to estimate different asphalt pavements' rutting depth clips, temperature, and load axes as primary characteristics. The experiment data were obtained from 19 asphalt pavements with different crude oil sources on a 2.038 km long full-scale field accelerated pavement test track (RIOHTrack, Road Track Institute) in Tongzhou, Beijing. In addition, this paper also proposes to build complex networks with different pavement rutting depths through complex network methods and the Louvain algorithm for community detection. The most critical structural elements can be selected from different asphalt pavement rutting data, and similar structural elements can be found. An extreme learning machine algorithm with residual correction (RELM) is designed and optimized using an independent adaptive particle swarm algorithm. The experimental results of the proposed method are compared with several classical machine learning algorithms, with predictions of Average Root Mean Squared Error, Average Mean Absolute Error, and Average Mean Absolute Percentage Error for 19 asphalt pavements reaching 1.742, 1.363, and 1.94\% respectively. The experiments demonstrate that the RELM algorithm has an advantage over classical machine learning methods in dealing with non-linear problems in road engineering. Notably, the method ensures the adaptation of the simulated environment to different levels of abstraction through the cognitive analysis of the production environment parameters.
Why accumulation mode organic electrochemical transistors turn off much faster than they turn on
Creators: name: Guo, Jiajie
name: Chen, Shinya E.
name: Giridharagopa, Rajiv
name: Bischak, Connor G.
name: Onorato, Jonathan W.
name: Yan, Kangrong
name: Shen, Ziqiu
name: Li, Chang-Zhi
name: Luscombe, Christine K.
name: Ginger, David S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Understanding the factors underpinning device switching times is crucial for the implementation of organic electrochemical transistors (OECTs) in neuromorphic computing and real-time sensing applications. Existing models of device operation cannot explain the experimental observations that turn-off times are generally much faster than turn-on times in accumulation mode OECTs. Through operando optical microscopy, we image the local doping level of the transistor channel and show that device turn-on occurs in two stages, while turn-off occurs in one stage. We attribute the faster turn-off to a combination of engineering as well as physical and chemical factors including channel geometry, differences in doping and dedoping kinetics, and the physical phenomena of carrier density-dependent mobility. We show that ion transport is limiting the device operation speed in our model devices. Our study provides insights into the kinetics of OECTs and guidelines for engineering faster OECTs.
Interfacial two-dimensional oxide enhances photocatalytic activity of graphene/titania via electronic structure modification
Creators: name: De Angelis, Dario
name: Presel, Francesco
name: Jabeen, Naila
name: Bignardi, Luca
name: Lizzit, Daniel
name: Lacovig, Paolo
name: Lizzit, Silvano
name: Montini, Tiziano
name: Fornasiero, Paolo
name: Alfè, Dario
name: Baraldi, Alessandro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A two-dimensional layer of oxide reveals itself as a essential element to drive the photocatalytic activity in a nanostructured hybrid material, which combines high-quality epitaxial graphene and titanium dioxide nanoparticles. In particular, it has been revealed that the addition of a 2D Ti oxide layer sandwiched between graphene and metal induces a p-doping of graphene and a consistent shift in the Ti d states. These modifications induced by the interfacial oxide layer induce a reduction of the probability of charge carrier recombination and enhance the photocatalytic activity of the heterostructure. This is indicative of a capital role played by thin oxide films in fine-tuning the properties of heterostructures based on graphene and pave the way to new combinations of graphene/oxides for photocatalysis-oriented applications.
The comprehensive analysis of different MS/MS acquisition modes and mass spectrometry related applications
Creators: name: Sibanda, Lloyd
Publisher: name: University of British Columbia
Year: 2022

description: For this work, two areas of metabolomics were investigated relating to the fundamentals of the field and application to different experiments. The first chapter was an assessment and comparison of the MSMS spectra generated from different acquisition modes. The chosen acquisition modes were data-dependant acquisition (DDA), data-independent acquisition (DIA), and enhanced insource-fragmentation (eISF) at a range of collision energies. The data was obtained by performing untargeted metabolomics on a urine sample and a standard mixture solution through a LC-MS platform while also covering multiple ionization modes. The spectra from the three modes were compared against each other through several factors that relate to the various ways MSMS spectra are used in a metabolomics workflow. These comparisons involved investigating the spectral purity, quality of reference matching results, structural similarity, and de novo annotation performance. It was found that DDA performed the best with eISF and DIA following. It was seen that eISF performed on-par or slightly better than DIA at higher collision energies. This indicates that the collision energy used will have a notable impact on the performance of the mode. The second chapter involves the metabolomics of pancreatic cell samples. The purpose of this was to determine the metabolic profile between the control and treated groups. The control was regular cancer cells from the MiaPaCa2 cell line while the treated groups had specific genes knocked out. The investigation was performed to gain insight into which metabolic pathways the knocked-out genes were involved in. Using a LC-MS platform it was found that 12 metabolites showed significant intensity differences between the groups. A literature review of these compounds highlighted possible metabolomic pathways affected such as polyamine metabolism. The last chapter focuses on a lipidomics experiment that was performed on the bacteria Thermotoga maritima to investigate the lipid content of the bacterial membranes. The samples relating to each fraction were run through the same LC-MS platform as above. It was seen that there were three significantly different lipids apart from the fatty acid, phosphatidylethanolamine, and phosphatidylinositol lipid classes. These classes have all been shown to be involved in membrane stability and transport.
Classification of discretely decomposable A_q(λ) with respect to reductive symmetric pairs
Creators: name: Kobayashi, Toshiyuki
name: Oshima, Yoshiki
Publisher: name: arXiv
Year: 2011
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 22E46, 53C35

description: We give a classification of the triples (g,g',q) such that Zuckerman's derived functor (g,K)-module A_q(λ) for a θ-stable parabolic subalgebra q is discretely decomposable with respect to a reductive symmetric pair (g,g'). The proof is based on the criterion for discretely decomposable restrictions by the first author and on Berger's classification of reductive symmetric pairs.
description: final version (to appear in Advances in Mathematics)
Neue Open-Access-Transformationsmodelle jenseits von DEAL
Creators: name: Schönfelder, Nina
name: Jobmann, Alexandra
Publisher: name: Zenodo
Year: 2019
Subjects: open access
transformation
open access modelle
subscribe to open
evidence-based open access
Kooperatives Deutschlandkonsortium

description: Präsentation folgender Open-Access-Transformationsmodelle beim 3. OA2020-DE-Transformationsworkshop am 03. und 04. April 2019 in Bielefeld:

	Subscribe to open
	Evidence-based Open Access
	Kooperatives Deutschlandkonsortium
The number of solutions of lambda(x)=n
Creators: name: Ford, Kevin
name: Luca, Florian
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We study the question of whether for each n there is another integer m with lambda(m)=lambda(n), where lambda is Carmichael's function. We give a "near" proof of the fact that this is the case unconditionally, and a complete conditional proof under the Extended Riemann Hypothesis. The main tool is a count of prime chains from paper arXiv:0906.3380.
description: v2. Corrected minor error on page 2. Updated reference [3]
Self-consistent effective-one-body theory for spinning binaries based on post-Minkowskian approximation
Creators: name: Jing, Jiliang
name: Deng, Weike
name: Long, Sheng
name: Wang, Jieci
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: This paper extends the research on the self-consistent effective-one-body theory of a real spinless two-body system based on the post-Minkowskian approximation (Science China, 65, 100411, (2022)) to the case of a binary system for the spinning black holes. An effective rotating metric and an improved Hamiltonian for the spinning black hole binaries were constructed. The decoupled equation for the null tetrad component of the gravitational perturbed Weyl tensor $ψ^B_{4}$ in the effective rotating spacetime is found with the help of the gauge transform characteristics of the Weyl tensors. The decoupled equation is then separated between radial and angular variables in the slowly rotating background spacetime, and a formal solution of $ψ^B_{4}$ is obtained. On this basis, the formal expressions of the radiation reaction force and the waveform for the ``plus'' and ``cross'' modes of the gravitational wave are presented. These results, obtained in the same effective spacetime, constitute a self-consistent effective-one-body theory for the spinning black hole binaries based on the post-Minkowskian approximation.
description: 29 pages. arXiv admin note: text overlap with arXiv:2208.02420
Growing Kai Under Increasing Dry: Adapting to Increasing Drought
Creators: name: Hazel, Jo-Anne
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 4101
subject: Climate change impacts and adaptation

description: Advice to central and regional government, industry bodies, and the research, science and innovation community on what is needed to better support primary sector adaptation to climate change, particularly drought. Commissioned by three National Science Challenges, bringing together insights from farmers, growers, industry bodies, researchers, and government about needs, roles and responsibilities for adapting to intensifying drought conditions.
Boundary Hölder continuity of stable solutions to semilinear elliptic problems in $C^{1,1}$ domains
Creators: name: Erneta, Iñigo U.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35B35, 35B45, 35B65, 35J15, 35J61

description: This article establishes the boundary Hölder continuity of stable solutions to semilinear elliptic problems in the optimal range of dimensions $n \leq 9$, for $C^{1,1}$ domains. We consider equations $- L u = f(u)$ in a bounded $C^{1,1}$ domain $Ω\subset \mathbb{R}^n$, with $u = 0$ on $\partial Ω$, where $L$ is a linear elliptic operator with variable coefficients and $f \in C^1$ is nonnegative, nondecreasing, and convex. The stability of $u$ amounts to the nonnegativity of the principal eigenvalue of the linearized equation $- L - f'(u)$. Our result is new even for the Laplacian, for which [Cabré, Figalli, Ros-Oton, and Serra, Acta Math. 224 (2020)] proved the Hölder continuity in $C^3$ domains.
description: Improved the presentation and removed Appendix C (now obsolete). To appear in J. Reine Angew. Math
Juggler's exclusion process
Creators: name: Leskelä, Lasse
name: Varpanen, Harri
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 60K35, 82C41

description: Juggler's exclusion process describes a system of particles on the positive integers where particles drift down to zero at unit speed. After a particle hits zero, it jumps into a randomly chosen unoccupied site. We model the system as a set-valued Markov process and show that the process is ergodic if the family of jump height distributions is uniformly integrable. In a special case where the particles jump according to a set-avoiding memoryless distribution, the process reaches its equilibrium in finite nonrandom time, and the equilibrium distribution can be represented as a Gibbs measure conforming to a linear gravitational potential.
description: 17 pages, 1 figure
Endnote 20 Workshop for Windows
Creators: name: HKU Libraries, Learning and Research Services
Publisher: name: HKU Data Repository
Year: 2021
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Endnote 20 is a citation management software and the HKU site license covers current HKU staff and students.
 Through this workshop, you will learn how to: Create an EndNote 20 library Build your Endnote 20 library by exporting citations from FIND@HKUL, Academic Search Complete and Google Scholar Create in-text citations and reference list in Word document using Cite While You Write Manage EndNote 20 library by creating groups
Endnote 20 Workshop for Mac
Creators: name: HKU Libraries, Learning and Research Services
Publisher: name: HKU Data Repository
Year: 2021
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Endnote 20 is a citation management software and the HKU site license covers current HKU staff and students.
Through this workshop, you will learn how to: Create an EndNote 20 library Build your Endnote 20 library by exporting citations from FIND@HKUL, Academic Search Complete and Google Scholar Create in-text citations and reference list in Word document using Cite While You WriteManage EndNote 20 library by creating groups
A theoretical survey to find potential natural compound for inhibition of binding the RBD domain to ACE2 receptor based on plant antivirals
Creators: name: Mahnam, Karim
name: Rajaee, Seyed Mehdi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The spike protein of coronavirus is crucial in binding and arrival of the virus to the human cell via binding to the human ACE2 receptor. In this study, at first 25 antiviral phytochemicals were docked into the RBD domain of spike protein, and then all complexes and free RBD domains were separately subjected to molecular dynamics simulation for 100 ns and MM/PBSA binding free energy calculation. In this phase, four ligands were chosen as hit compounds and a natural compound database (NPASS) was screened based on high similarity with these ligands, and 367 ligands were found. Then the same previous procedure was repeated for these ligands and ADME properties were investigated. Finally, virtual screening and 4400 ns MD simulation and MM/PBSA calculation revealed that new ligands including NPC67959, NPC157855, NPC248793, and NPC216361 can inhibit the RBD domain of spike protein and we propose them as potential drugs for experimental studies. Communicated by Ramaswamy H. Sarma
Asymptotics of a Gauss hypergeometric function with two large parameters: A new case
Creators: name: Harper, John
Publisher: name: Open Access Victoria University of Wellington | Te Herenga Waka
Year: 2021
Subjects: Uncategorized

description: Asymptotic expansions of the Gauss hypergeometric function with large parameters, {equation presented}, are known for many special cases, but not for one that the author encountered in recent work on fluid mechanics: ϵ2 = 0 and.ϵ3=ϵ1z. This paper gives the leading term for that case if β is not a negative integer and z is not on the branch cut [1, ∞), and it shows how subsequent terms can be found. © Australian Mathematical Society 2019. This is the author's version of the article. This version is published under a Creative Commons CC-BY-NC-ND. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. The Version of Record was published in The ANZIAM Journal https://doi.org/10.1017/S1446181119000166.
Charged strange star model in Tolman-Kuchowicz spacetime in the background of 5D Einstein-Maxwell-Gauss-Bonnet gravity
Creators: name: Rej, Pramit
name: Errehymy, Abdelghani
name: Daoud, Mohammed
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this article, we provide a new model of static charged anisotropic fluid sphere made of a charged perfect fluid in the context of 5D Einstein-Maxwell-Gauss-Bonnet (EMGB) gravity theory. To generate exact solutions of the EMGB field equations, we utilize the well-behaved Tolman-Kuchowicz (TK) {\it ansatz} together with a linear equation of state (EoS) of the form $p_r=βρ-γ$, (where $β$ and $γ$ are constants). Here the exterior space-time is described by the EGB Schwarzschild metric. The Gauss-Bonnet Lagrangian term $\mathcal{L}_{GB}$ is coupled with the Einstein-Hilbert action through the coupling constant $α$. When $α\to 0$, we obtain the general relativity (GR) results. Here we present the solution for the compact star candidate EXO 1785-248 with mass$=(1.3 \pm 0.2)M_{\odot}$; Radius $= 10_{-1}^{+1}$ km. respectively. We analyze the effect of this coupling constant $α$ on the principal characteristics of our model, such as energy density, pressure components, anisotropy factor, sound speed etc. We compare these results with corresponding GR results. Moreover, we studied the hydrostatic equilibrium of the stellar system by using a modified Tolman-Oppenheimer-Volkoff (TOV) equation and the dynamical stability through the critical value of the radial adiabatic index.The mass-radius relationship is also established to determine the compactness factor and surface redshift of our model. In this way, the stellar model obtained here is found to satisfy the elementary physical requirements necessary for a physically viable stellar object.
description: 16 Pages, 11 Figures and 1 Table
Kondo Temperature in Multilevel Quantum Dots
Creators: name: Garate, Ion
name: Affleck, Ian
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We develop a general method to evaluate the Kondo temperature in a multilevel quantum dot that is weakly coupled to conducting leads. Our theory reveals that the Kondo temperature is strongly enhanced when the intradot energy-level spacing is comparable to or smaller than the charging energy. We propose an experiment to test our result, which consists of measuring the size-dependence of the Kondo temperature.
description: 4 pages, 1 figure and supplementary material. Revised and improved version, to appear in Phys. Rev. Lett
Molecular docking and dynamics simulation of Orthosiphon stamineus against SGLT1 and SGLT2
Creators: name: Subbiah, Usha
name: Ajith, Athira
name: Subbiah, Harini Venkata
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Orthosiphon stamineus Benth a traditional medicine used in the treatment of diabetes and kidney diseases. Sodium–glucose co-transporter (SGLT1 and SGLT2) inhibitors are the novel group of drugs used to treat patients with type 2 diabetes mellitus. In this study 20 phytochemical compounds from Orthosiphon stamineus Benth were obtained from 3 databases viz Dr.Duke’s phytochemical, Ethno botanical database and IMPPAT. They were subjected to physiochemical, drug likeliness, and ADMET and toxicity predictions. Homology modeling and molecular docking against SGLT1 and SGLT2 were performed and the stability of the selected drug molecule was validated by molecular dynamic (MD) simulation for 200 ns. Among the 20 compounds, 14-Dexo-14-O-acetylorthosiphol Y alone showed higher binding affinity with SGLT1 and SGLT2 protein with the binding energy of −9.6 and −11.4 Kcal/mol respectively and had highest affinity towards SGLT2 inhibitor. This compound also satisfied Lipinski rule of 5 and had a good ADMET profile. The compound is non-toxic to marine organisms and to normal cell lines and non-mutagenic. The RMSD value attained equilibrium at 150 ns with the stability around 4.8 Å and no significant deviation was reported from 160 to 200 ns for SGLT2. Our study suggests that 14-Dexo-14-O-acetylorthosiphol Y showed promising results against the SGLT2 and could be considered as a potent anti-diabetic drug. Communicated by Ramaswamy H. Sarma
Hepatic Angiomyolipoma: a case report
Creators: name: HOUDA, MATTICHE
Publisher: name: EURORAD
Year: 2014
Subjects: subject: Abdomen
subject: CT
subject: Diagnostic procedure
subject: Tissue characterisation

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 55 years
description: Clinical History: 55 year old women with no previous medical history,presents a hepatic colic (five months ago). Physical examination showed no abnormalities in particular no clinical signs for tuberous sclerosis. Liver function tests was normal. An US examination wa... Final Diagnosis: Hepatic angiomyolipoma
Theoretical dark matter halo density profile
Creators: name: Salvador-Solé, Eduard
name: Viñas, Jordi
name: Manrique, Alberto
name: Serra, Sinue
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We derive the density profile for collisionless dissipationless dark matter haloes in hierarchical cosmologies making use of the Secondary Infall (SI) model. The novelties are: i) we deal with triaxial virialised objects; ii) their seeds in the linear regime are peaks endowed with {\it unconvolved} spherically averaged density profiles according to the peak formalism; iii) the initial peculiar velocities are taken into account; and iv) accreting haloes are assumed to develop from the inside out, keeping the instantaneous inner system unaltered. The validity of this latter assumption is accurately checked by comparing analytical predictions on such a growth with the results of numerical simulation. We show that the spherically averaged density profile of virialised objects can be inferred with no need to specify their shape. The {\it typical} spherically averaged halo density profile is inferred, down to arbitrarily small radii, from the power-spectrum of density perturbations. The predicted profile in the $Λ$CDM cosmology is approximately described by an Einasto profile, meaning that it does not have a cusp but rather a core, where the inner slope slowly converges to zero. Down to one hundredth the total radius, the profile has the right NFW and Einasto forms, being close to the latter down to a radius of about four orders of magnitude less. The inner consistency of the model implies that the density profiles of haloes harbour no information on their past aggregation history. This would explain why major mergers do not alter the typical density profile of virialised objects formed by SI and do not invalidate the peak formalism based on such a formation.
description: 14 pages, 7 figures. Published in MNRAS
Reactive pulsed direct current magnetron sputtering deposition of semiconducting yttrium oxide thin film in ultralow oxygen atmosphere: A spectroscopic and structural investigation of growth dynamics
Creators: name: Arslan, H.
name: Aulika, I.
name: Sarakovskis, A.
name: Bikse, L.
name: Zubkins, M.
name: Azarov, A.
name: Gabrusenoks, J.
name: Purans, J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: An experimental investigation was conducted to explore spectroscopic and structural characterization of semiconducting yttrium oxide thin film deposited at 623 K (+/- 5K) utilizing reactive pulsed direct current magnetron sputtering. Based on the results obtained from both x-ray diffraction and transmission electron microscope measurements, yttrium monoxide is very likely formed in the transition region between β-Y2O3 and α-Y2O3, and accompanied by the crystalline Y2O3. Resulting from either the low energy separation between 4d and 5s orbitals and/or different spin states of the corresponding orbitals' sublevels, the stability of monoxide is most presumably self-limited by the size of the crystal in thermodynamic terms. This behavior develops a distortion in the structure of the crystal compared to the metal oxide cubic structure and it also effectuates the arrangement in nanocrystalline/amorphous phase. In addition to this, spectroscopic ellipsometry denotes that the semiconducting yttrium oxide has the dominant, mostly amorphous, formation character over crystalline Y2O3. Our purpose, by means of the current findings, is to advance the understanding of formation kinetics/conditions of yttrium with an unusual valency (2+).
Identification and validation of novel non-nucleoside class of molecules inhibiting the dengue virus replication
Creators: name: Roy, Kuldeep K.
name: Jyothi, Deeti
name: Paul, Udita
name: Sukla, Soumi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: There is currently no drug available to treat mosquito-borne dengue. The C-terminal RNA-dependent RNA polymerase (RdRp) domain in the non-structural type 5 (NS5) protein of the dengue virus (DENV) is essential for viral RNA synthesis and replication, and therefore, it is an attractive target for the anti-dengue drug development. We report herein the discovery and validation of two novel non-nucleoside classes of small molecules as DENV RdRp inhibitors. Firstly, using the refined X-ray structure of the DENV NS5 RdRp domain (PDB-ID: 4V0R), we conducted docking, binding free-energy studies, and short-scale molecular dynamics simulation to investigate the binding sites of known small molecules that led to the optimized protein–ligand complex. Subsequently, protein structure-based screening of a commercial database (∼500,000 synthetic compounds), pre-filtered for the drug-likeness, led to the top-ranked 171 molecules, which was then subjected to structural diversity analysis and clustering. This process led to six structurally distinct and best-scored compounds that were procured from the commercial vendor, and then subjected to the in vitro testing in the MTT and dengue infection assays. It revealed two unique and structurally unique compounds, KKR-D-02 and KKR-D-03, exhibiting 84 and 81% reductions, respectively, in DENV copy number in repeated assays in comparison to the virus-infected cell controls. These active compounds represent novel scaffolds for further structure-based discovery of novel candidate molecules for the intervention of dengue. Communicated by Ramaswamy H. Sarma
Miniature objective lens design for multiphoton microscopy
Creators: name: Brandt, Christoph Tobias
Publisher: name: University of British Columbia
Year: 2022

description: Multiphoton microscopy is a promising imaging technique capable of optical sectioning to acquire images from below the surface of tissue. A miniature objective with depth-scanning capability is needed for clinically adaptation. Imaging performance is dependent upon the ability to focus pulsed laser light. State-of-the-art endoscopes have a depth-scanning capability of ~200 μm and suffer from a significant decrease in resolution at the limit of their depth-scanning range. Zemax software is used to evaluate aspherical lenses for use as objectives, to evaluate the effect of scanning optics, and to design a custom water-dipping objective. Simulations show that the custom objective is capable of achieving diffraction-limited focusing for depths from 0 μm to 1400 μm in water by minimizing spherical aberration. A shape memory alloy actuator is used by the objective for depth-scanning across a 440 μm range, which is experimentally demonstrated by imaging fluorescent beads across the entire range and is more than double the range capability of MPM endoscopes in literature. Resolution measured ~0.7 μm laterally and ~10 μm axially and remained consistent across the entire depth-scanning range. This is a significant improvement to both our lab’s imaging ability and to the depth-scanning abilities of endoscopes presented in literature. Resolution is improved by the addition of corrective optics that reduces axial chromatic aberration. The effect of chromatic aberration on the focusing ability of the custom objective is investigated via simulation using Zemax. Simulations show that the 3 dB wavelengths of the laser’s 80 fs pulses focus at a different depth than the central wavelength and also that marginal rays and on-axis rays arrive at the focal point at different times. By adding CO to reduce chromatic aberration, both of these differences are significantly reduced, which improves the signal to noise ratio. An equation to calculate the difference in arrival time is derived, which shows that the difference is proportional to the square of the objective’s numerical aperture. The deep imaging capabilities of the water-dipping miniature MPM objective is demonstrated by imaging tissue and shows great promise for future clinical use.
Precise predictions for (non-standard) W+photon+jet production
Creators: name: Campanario, Francisco
name: Englert, Christoph
name: Spannowsky, Michael
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We report on a detailed investigation of the next-to-leading order (NLO) QCD corrections to $Wγ$+jet production at the Tevatron and the LHC using a fully-flexible parton-level Monte Carlo program. We include the full leptonic decay of the $W$, taking into account all off-shell and finite width effects, as well as non-standard $WWγ$ couplings. We find particularly sizable corrections for the currently allowed parameter range of anomalous couplings imposed by LEP data. In total the NLO differential distributions reveal a substantial phase space dependence of the corrections, leaving considerable sensitivity to anomalous couplings beyond scale uncertainty at large momentum transfers in the anomalous vertex.
description: 22 pages, 14 figures, 2 tables, published version