cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Blueprint for #CitSciComm with and for Career Scientists (D4.3)
Creators: name: Luís, Cristina
name: Navalhas, Inês
name: Marín-González, Esther
name: Magalhães, Joana
name: Guasch, Blanca
name: Perucca Iannitelli, Carla
name: Leguina, Leire
name: Elorza, Ana
name: Lacunza, Izaskun
name: Citarella, Maria Angela
name: Giardullo, Paolo
name: Tola, Elisabetta
name: Pelacho, Maite
name: Arias, Rosa
Publisher: name: Zenodo
Year: 2023
Subjects: science communication; citizen science;

description: NEWSERA Blueprints for citizen science communication (#citscicomm) with and for quadruple helix stakeholders (citizens and society at large, academic scientists, public sector and policymakers, industry and SMES) and science and data journalists is an instrument that can serve a general audience, including those who are planning to start a citizen science (CS) project, those who want to improve and/or rethink their communication strategies in order to increase specific target audiences, or those who want to enlarge their scope of action by involving the different actors of the quadruple helix model and the media. The road for CS projects establishment and sustainability is long and there are many barriers to be faced. But you are not alone! Together with 39 CS projects from Italy, Spain and Portugal, the NEWSERA Pilots, we have tested the NEWSERA methodology for the co-design, implementation, iterative assessment and validation of communication strategies directed to each of the quadruple helix stakeholders and science and data journalists. This was performed through our #CitSciComm Labs, dedicated to each individual stakeholder, consisting of three rounds of workshops, replicated in each of the participating countries, throughout three years. In this series of five blueprints, NEWSERA brings the learnings of this co-created process together with our pilots, invited stakeholders and science communication experts (NEWSERA Sounding Board) that was complemented with mentoring, capacity building and networking sessions, generating knowledge, recommendations and useful resources. In this blueprint, dedicated to career scientists as target stakeholder, you will find, more in depth, the importance to address this stakeholder, good practices on the co-design of targeted communication plans, elements of co-design, mutual benefits of CS project-stakeholder, and indicators. Furthermore, a description and details of messages, innovative tools, channels and specific case-studies from the NEWSERA Pilots are included. Finally, we shared a series of recommendations to efficiently engage with quadruple helix stakeholders and science and data journalists for wider impact and ensure replicability of the NEWSERA findings and science communication strategies in citizen science projects and beyond.
Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: CRISPR/Cas9
HIV-1
gene editing

description: © 2018 We used NOD/SCID mice, also known as NRG, to assess the ability of lentivirus-mediated intravenous delivery of CRISPR in editing the HIV-1 genome from the circulating PBMC engrafts, some of which homed within several animal solid tissues. Lentivirus-mediated delivery of a multiplex of guide RNAs accompanied by Cas9 endonuclease led to the excision of the targeted region of the viral genome positioned within the HIV-1 LTR from the in-vitro-infected human peripheral blood mononuclear cells (PBMCs) embedded in the spleens of NRG mice. Similarly, the treatment of NRG mice harboring PBMC engrafts derived from HIV-1-positive patients with the therapeutic lentivirus eliminated the presence of the viral DNA fragment in the blood, as well as in the spleen, lung, and liver, of the engrafted animals. Sanger sequence analysis of the viral DNA after treatment with the lentiviral vectors expressing Cas9 and gRNAs verified the editing and removal of the proviral DNA fragment from the viral genome at the predicted sites. This proof-of-concept study, for the first time, demonstrates successful excision of the HIV-1 proviral DNA from patient immune cell engrafts in humanized mice upon treatment with lentivirus-expressing CRISPR and causes a decline in the level of replication-competent virus.
Niedersächsische Staats- und Universitätsbibliothek, Göttingen
Creators: name: Erkkilä, Ville
Publisher: name: Zenodo
Year: 2018
Subjects: Paul Koschaker
Helmut Coing
Rudolf Smend
Franz Wieacker

description: Archival notes from Niedersächsische Staats- und Universitätsbibliothek, Göttingen. NL Rudolf Smend, Cod. Ms. R. Smend A960 Wieacker: Letters from Franz Wieacker to Rudolf Smend. NL Franz Wieacker, Cod. Ms. F. Wieacker: Remaining papers of Franz Wieacker. Manuscripts of books, reference lists, some lecture notes, few letters. Cod. Ms. R. Smend P9: Paul Koschaker’s congrats for Rudolf Smend (7 letters) for his appointment to University of Leipzig. Cod. Ms. R. Smend A130: Helmut Coing’s letters to Rudolf Smend.
The Case for Durative Actions: A Commentary on PDDL2.1
Creators: name: Smith, D. E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The addition of durative actions to PDDL2.1 sparked some controversy. Fox and Long argued that actions should be considered as instantaneous, but can start and stop processes. Ultimately, a limited notion of durative actions was incorporated into the language. I argue that this notion is still impoverished, and that the underlying philosophical position of regarding durative actions as being a shorthand for a start action, process, and stop action ignores the realities of modelling and execution for complex systems.
THE EFFICACY OF SILVERSEPT TOPICAL AND CHITOHEAL GEL IN WOUND HEALING: A CASE REPORT
Creators: name: Balasubramaniam, Subramaniam
name: Setaffa Zabariah
name: Saifuddin, Ismail Mohd
Publisher: name: Zenodo
Year: 2021
Subjects: Wound healing; antimicrobial agent; chitosan biopolymer

description: Introduction: Wound healing is defined as a complex series of interactions and reactions among the “mediators” and cells in four overlapping and distinct phases which are influenced by several local and systemic factors. The authors noted Silversept spray and ChitoHeal gel dressing facilitates and fastens wound healing. Methods and materials: Wound cleaned with cleansing solution, silver antiseptic spray was sprayed at wound, ChitoHeal gel was applied, wound covered with non-adherent pad and gauze as secondary dressing, dressing was done every alternate days. Results: 52 years old Indian male with underlying DM on 2 types of OHA, presented with necrotising fasciitis of left lower limb. Patient was seen by wound team at ward post wound debridement (Figure 1). Advanced dressing was done for patient with Silversept spray and ChitoHeal gel for 2/52 weeks (Figure 2). Wound healing progressed well and split skin graft (SSG) was proceeded for patient after Day 17 of Silversept spray and ChitoHeal gel dressing. Post SSG, dressing was continued with Silversept spray and ChitoHeal gel. Good wound healing was seen subsequently in 15 days (Figure 3) and wound healed well 26 days post SSG (Figure 4). Discussion: Silversept spray contains nano colloidal silver, a safe and effectively used broad spectrum antimicrobial agent. It had been tested and proven to kill the strains of vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). The silver ions which released by nanoparticles with the existence of sodium ions in wound, produces antimicrobial effect towards microorganisms, including bacteria those are antibiotic resistant. ChitoHeal gel consists of chitosan biopolymer which exhibits enzymatic biodegradability, immuno-stimulation, chemotactic action and muco-adhesion characteristics. These properties facilitate haemostasis and accelerate wound healing, thus used in wound care to prevent complications such as poor wound healing. In addition to this, chitosan biopolymer too repairs and grows peripheral nervous system neurons due to presence of ability to support migration, proliferation and adhesion of Schwann cells. Conclusion: In this review, properties in addition to the benefits exhibited by nano colloidal silver and chitosan polymers, compositions of Silversept spray and Chitoheal gel respectively had been highlighted. This case report too points out that usage of Silversept topical and ChitoHeal Gel in wound management has excellent outcome.
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) in August 18-20 2021. https://nccrconference.com.my/
Discovery of topological nodal-line fermionic phase in a magnetic material GdSbTe
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018

description: © 2018, The Author(s). Topological Dirac semimetals with accidental band touching between conduction and valence bands protected by time reversal and inversion symmetry are at the frontier of modern condensed matter research. A majority of discovered topological semimetals are nonmagnetic and conserve time reversal symmetry. Here we report the experimental discovery of an antiferromagnetic topological nodal-line semimetallic state in GdSbTe using angle-resolved photoemission spectroscopy. Our systematic study reveals the detailed electronic structure of the paramagnetic state of antiferromagnetic GdSbTe. We observe the presence of multiple Fermi surface pockets including a diamond-shape, and small circular pockets around the zone center and high symmetry X points of the Brillouin zone (BZ), respectively. Furthermore, we observe the presence of a Dirac-like state at the X point of the BZ and the effect of magnetism along the nodal-line direction. Interestingly, our experimental data show a robust Dirac-like state both below and above the magnetic transition temperature (TN = 13 K). Having a relatively high transition temperature, GdSbTe provides an archetypical platform to study the interaction between magnetism and topological states of matter.
Международные отношения и Регионоведение,Выпуск 2 (52) 2023
Creators: name: АО «КазУМОиМЯ им.Абылай хана»
Publisher: name: АО «КазУМОиМЯ им.Абылай хана»
Year: 2023

description: Международные отношения и Регионоведение,Выпуск 2 (52) 2023
Good things for those who wait: Predictive modeling highlights importance of delay discounting for income attainment
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: income
salary
delay discounting
predictive modeling
machine learning

description: © 2018 Hampton, Asadi and Olson. Income is a primary determinant of social mobility, career progression, and personal happiness. It has been shown to vary with demographic variables like age and education, with more oblique variables such as height, and with behaviors such as delay discounting, i.e., the propensity to devalue future rewards. However, the relative contribution of each these salary-linked variables to income is not known. Further, much of past research has often been underpowered, drawn from populations of convenience, and produced findings that have not always been replicated. Here we tested a large (n = 2,564), heterogeneous sample, and employed a novel analytic approach: using three machine learning algorithms to model the relationship between income and age, gender, height, race, zip code, education, occupation, and discounting. We found that delay discounting is more predictive of income than age, ethnicity, or height. We then used a holdout data set to test the robustness of our findings. We discuss the benefits of our methodological approach, as well as possible explanations and implications for the prominent relationship between delay discounting and income.
Blueprint for #CitSciComm with and for science journalists (D4.6)
Creators: name: Tola, Elisabetta
name: Magalhães, Joana
name: Guasch, Blanca
name: Luís, Cristina
name: Navalhas, Inês
name: Marín- González, Esther
name: Leguina, Leire
name: Citarella, Maria Angela
name: Giardullo, Paolo
name: Pelacho, Maite
name: Arias, Rosa
Publisher: name: Zenodo
Year: 2023
Subjects: science communication; citizen science

description: NEWSERA Blueprints for citizen science communication (#citscicomm) with and for quadruple helix stakeholders (citizens and society at large, academic scientists, public sector and policymakers, industry and SMES) and science and data journalists is an instrument that can serve a general audience, including those who are planning to start a citizen science (CS) project, those who want to improve and/or rethink their communication strategies in order to increase specific target audiences, or those who want to enlarge their scope of action by involving the different actors of the quadruple helix model and the media. The road for CS projects establishment and sustainability is long and there are many barriers to be faced. But you are not alone! Together with 39 CS projects from Italy, Spain and Portugal, the NEWSERA Pilots, we have tested the NEWSERA methodology for the co-design, implementation, iterative assessment and validation of communication strategies directed to each of the quadruple helix stakeholders and science and data journalists. This was performed through our #CitSciComm Labs, dedicated to each individual stakeholder, consisting of three rounds of workshops, replicated in each of the participating countries, throughout three years. In this series of five blueprints, NEWSERA brings the learnings of this co-created process together with our pilots, invited stakeholders and science communication experts (NEWSERA Sounding Board) that was complemented with mentoring, capacity building and networking sessions, generating knowledge, recommendations and useful resources. In this blueprint, dedicated to science and data journalists as target stakeholder, you will find, more in depth, the importance to address this stakeholder, good practices on the co-design of targeted communication plans, elements of co-design, mutual benefits of CS project-stakeholder, and indicators. Furthermore, a description and details of messages, innovative tools, channels and specific case-studies from the NEWSERA Pilots are included. Finally, we shared a series of recommendations to efficiently engage with quadruple helix stakeholders and science and data journalists for wider impact and ensure replicability of the NEWSERA findings and science communication strategies in citizen science projects and beyond.
Numerical simulations of shocks encountering clumpy regions
Creators: name: Alūzas, R.
name: Pittard, J. M.
name: Hartquist, T. W.
name: Falle, S. A. E. G.
name: Langton, R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present numerical simulations of the adiabatic interaction of a shock with a clumpy region containing many individual clouds. Our work incorporates a sub-grid turbulence model which for the first time makes this investigation feasible. We vary the Mach number of the shock, the density contrast of the clouds, and the ratio of total cloud mass to inter-cloud mass within the clumpy region. Cloud material becomes incorporated into the flow. This "mass-loading" reduces the Mach number of the shock, and leads to the formation of a dense shell. In cases in which the mass-loading is sufficient the flow slows enough that the shock degenerates into a wave. The interaction evolves through up to four stages: initially the shock decelerates; then its speed is nearly constant; next the shock accelerates as it leaves the clumpy region; finally it moves at a constant speed close to its initial speed. Turbulence is generated in the post-shock flow as the shock sweeps through the clumpy region. Clouds exposed to turbulence can be destroyed more rapidly than a similar cloud in an "isolated" environment. The lifetime of a downstream cloud decreases with increasing cloud-to-intercloud mass ratio. We briefly discuss the significance of these results for starburst superwinds and galaxy evolution.
description: 17 pages, 19 figures, accepted for publication in MNRAS
What you need to know about DMPs
Creators: name: Jones, Sarah
Publisher: name: Zenodo
Year: 2018
Subjects: DMP, Data Management Plan, data policy, funder, review, tools, DMPonline, DMPOpidor, DMPTuuli, RDMOrganiser, OpenDMP, EasyDMP, machine-actionable, DMP, Open, open data, open access,

description: Presentation given as part of the 2018 OpenAIRE-FOSTER Open Access week webinar series. The tutorial is aimed at librarians and data support staff who are assisting researchers with Data Management Plans (DMPs). It reflects on recent trends and developments that will help in service delivery, including changing policies for DMPs, how funders review DMPs, new tools and international activities to make DMPs Open, machine-actionable and FAIR.
Post-Prescription Review and Feedback: The Hospital Queen Elizabeth II Experience
Creators: name: Anith Binti A.Aziz
name: Liang, Goh Qing
name: Liew Yen Wei Kevin
Publisher: name: Zenodo
Year: 2021
Subjects: Antimicrobial resistance; broad spectrum antibiotic; overutilization

description: Introduction: Hospital Queen Elizabeth II (HQEII) implemented post-prescription review and feedback (PPRF) as part of our antimicrobial stewardship strategy. Objectives: This study evaluates PPRF conducted twice weekly in HQEII and compares its impact on antibiotic consumption. Methods: This study was a retrospective cross-sectional study conducted from July to December 2019 from data collected during PPRF rounds. Antimicrobial consumption was compared with previous year using the defined daily dosing measures. Results: A total of 847 PPRF reviews involving 538 patients receiving restricted antibiotics. Amongst these patients, 61.0% of them were men with a median age of 57 years old (IQR 41 - 68). The wards most visited during PPRF were the medical ward (n=354, 41.7%), followed by the intensive care unit (n=, 13.6%) and orthopedic ward (n=, 13.2%). It took an average of 2.5±2.3 days for the AMS team to conduct a review after an antibiotic was started. The antibiotic most reviewed was 3rd generation cephalosporins (n=273, 32.2%). The commonest diagnoses that prompted review was a respiratory tract infection (n=243, 28.7%). Antibiotics were de-escalated in half of the reviews (n=425, 50.1%). The impact of the PPRF review on antibiotic consumption was observed in certain antibiotics. In particular, PPRF intervention significantly reduced consumption of antibiotics such as cefuroxime by 42% (62.0 vs 20.1, p<0.001), ceftriaxone by 41.3% (67.4 vs 26.1, p<0.001), and piperacillin-tazobactam by 12.3% (40.6 vs 28.2, p<0.017). Conclusion: Intensive PPRF successfully reduces consumption of certain antibiotics. More studies are warranted to further analyze PPRF impact on clinical, microbiological, and economic outcomes. [Disclaimer: Abstract text might vary slightly from what is displayed in the e-poster]
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) in August 18-20 2021. https://nccrconference.com.my/
Dynamics of Bid-ask Spread Return and Volatility of the Chinese Stock Market
Creators: name: Qiu, Tian
name: Chen, Guang
name: Zhong, Li-Xin
name: Wu, Xiao-Run
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Finance (q-fin.ST)
subject: Physics and Society (physics.soc-ph)
subject: Trading and Market Microstructure (q-fin.TR)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: Bid-ask spread is taken as an important measure of the financial market liquidity. In this article, we study the dynamics of the spread return and the spread volatility of four liquid stocks in the Chinese stock market, including the memory effect and the multifractal nature. By investigating the autocorrelation function and the Detrended Fluctuation Analysis (DFA), we find that the spread return is lack of long-range memory, while the spread volatility is long-range time correlated. Moreover, by applying the Multifractal Detrended Fluctuation Analysis (MF-DFA), the spread return is observed to possess a strong multifractality, which is similar to the dynamics of a variety of financial quantities. Differently from the spread return, the spread volatility exhibits a weak multifractal nature.
Three-dimensional shapelets and an automated classification scheme for dark matter haloes
Creators: name: Fluke, C. J.
name: Malec, A. L.
name: Lasky, P. D.
name: Barsdell, B. R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We extend the two-dimensional Cartesian shapelet formalism to d-dimensions. Concentrating on the three-dimensional case, we derive shapelet-based equations for the mass, centroid, root-mean-square radius, and components of the quadrupole moment and moment of inertia tensors. Using cosmological N-body simulations as an application domain, we show that three-dimensional shapelets can be used to replicate the complex sub-structure of dark matter halos and demonstrate the basis of an automated classification scheme for halo shapes. We investigate the shapelet decomposition process from an algorithmic viewpoint, and consider opportunities for accelerating the computation of shapelet-based representations using graphics processing units (GPUs).
description: 19 pages, 11 figures, accepted for publication in MNRAS
title: Συγκριτική αξιολόγηση πρόσθετων ανοικτού κώδικα του wordpress και ανάπτυξη ενημερωτικού ιστολογίου
title: Comparative evaluation of wordpress open source add-ons and development of an informative blog
titleType: AlternativeTitle
Creators: name: Αλεξανδρή, Ευσταθία
name: Μελά, Δήμητρα Μαρία
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Wordpress
CMS
Content management system
Συστήματα διαχείρισης περιεχομένου
Plugins
Ευχρηστία
Αξιοπιστία

description: Η παρούσα εργασία αναλύει τα Συστήματα Διαχείρισης Περιεχομένου (CMS) που ευρέως χρησιμοποιούνται στη σύγχρονη κατασκευή ιστοσελίδων, με εστίαση στο Wordpress, ένα από τα κορυφαία CMS στην αγορά. Τα CMS αυτά παρέχουν στους χρήστες την δυνατότητα επέκτασης της λειτουργικότητας των ιστοσελίδων τους μέσω της χρήσης πρόσθετων plugins, τα οποία διευκολύνουν την ενσωμάτωση νέων λειτουργιών και δυνατοτήτων , χωρίς την ανάγκη για εξωτερικές παρεμβάσεις στην ανάπτυξη και συντήρηση προσαρμοσμένων λειτουργιών. Στην εργασία αυτή, προβαίνουμε στη συγκριτική αξιολόγηση των πιο δημοφιλών plugins, βασιζόμενοι σε κριτήρια αξιοπιστίας, καθώς και τα κριτήρια ευχρηστίας του Nielsen. Επίσης, δημιουργήσαμε ένα ενημερωτικό blog μέσω του ίδιου του Wordpress, όπου παρουσιάζουμε τα plugins που αξιολογήσαμε. Μέσω αυτής της εργασίας, παρέχουμε στους χρήστες του Wordpress και άλλων CMS μια κατανοητή και ενημερωμένη επισκόπηση των πιο αξιόπιστων και χρήσιμων plugins, καθώς και τον σωστό τρόπο επιλογής τους.
NEWSERA Indicators for Communication Strategies of Citizen Science Projects
Creators: name: Giardullo, Paolo
name: Citarella, Maria Angela
name: Pelacho, Maite
name: Magalhães, Joana
name: Luís, Cristina
name: Navalhas, Inês
name: Marín-González, Esther
name: Leguina, Leire
name: Arias, Rosa
Publisher: name: Zenodo
Year: 2023
Subjects: indicators; science communication; citizen science

description: The following document presents a set of indicators (Table 1) defined by the NEWSERA consortium for the evaluation of communication specifically aimed at the quadruple helix agents (citizens and society as a whole, academia, industry and SMEs, public sector and policymakers) and journalists, by citizen science projects. As explained in the "Report on indicators for impact assessment of science communication in Citizen Science Projects" (Giardullo et al. 2021), NEWSERA established a multilevel impact assessment framework, considering impact assessment in three sources: Science Communication Actions (from initial NEWSERA Impact Assessment), the evaluation of Science Communication in different dimensions (from ACTION Project), and the Responsible Research and Innovation (RRI) pillars (from the MoRRI and Super-MoRRI projects), for the analysis and evaluation of communication tools and strategies co-designed by Science Communication projects. Based on this framework model, the NEWSERA Indicators were organised in three key macro-areas, Communication, Participation of quadruple helix stakeholders and Impact, each with three related sub-areas, and indicators. In addition, through a process of iterative evaluation, the different indicators have been tested and refined, always in a co-created way together with NEWSERA pilot projects, in a continuous work of mentoring, cooperation and shared learning.
FFDNet: Toward a fast and flexible solution for CNN-Based image denoising
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: cs.CV

description: © 1992-2012 IEEE. Due to the fast inference and good performance, discriminative learning methods have been widely studied in image denoising. However, these methods mostly learn a specific model for each noise level, and require multiple models for denoising images with different noise levels. They also lack flexibility to deal with spatially variant noise, limiting their applications in practical denoising. To address these issues, we present a fast and flexible denoising convolutional neural network, namely FFDNet, with a tunable noise level map as the input. The proposed FFDNet works on downsampled sub-images, achieving a good trade-off between inference speed and denoising performance. In contrast to the existing discriminative denoisers, FFDNet enjoys several desirable properties, including: 1) the ability to handle a wide range of noise levels (i.e., [0, 75]) effectively with a single network; 2) the ability to remove spatially variant noise by specifying a non-uniform noise level map; and 3) faster speed than benchmark BM3D even on CPU without sacrificing denoising performance. Extensive experiments on synthetic and real noisy images are conducted to evaluate FFDNet in comparison with state-of-the-art denoisers. The results show that FFDNet is effective and efficient, making it highly attractive for practical denoising applications.
The Development of a Per-O-Benzylated 1-C-Aryl-glycal for the Synthesis of Kdo Glycosides
Creators: name: Maillet, Robert
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Chemistry--Organic
subject: Kdo
subject: Synthesis
subject: glycosylation

description: 3-Deoxy-D-manno-octulosonic acid (Kdo) is a key component of lipopolysaccharides (LPS) found in all gram-negative bacteria. The Kdo sugar exists almost exclusively in alpha-glycoside form and is essential for bacterial survival. Previously the Ling group has shown that a 1-C-aryl-3,4;6,7-diisopropylidenated heptose glycal can be a versatile donor for the synthesis beta-Kdo glycosides. The glycosylation was accomplished with high regio- and stero- selectivities by using N-iodosuccinimide (NIS). It was postulated that the reason for the observed beta-glycosylyation results arose from the presence of a fused isopropylidene ring on the top face of the glycal therefore directing via steric repulsion the formation of a the beta-Kdo glycoside. The goal of this thesis was to exchange the fused isopropylidene rings on the glycal with acyclic protecting groups so as to test if glycosylation results could be made to favor formation of a more stable and desired alpha-Kdo glycoside. Chapter 1 gives a brief introduction of bacterial polysaccharides, in particular, lipopolysaccharides (LPSs) produced by gram-negative bacteria and also Kdo monosaccharide. The biological functions and biosynthetic pathway of LPSs are also summarized. Chapter 2 provides detailed reviews on chemical methodologies reported in the literature for the synthesis of Kdo. Chapter 3 details the work of this thesis towards the development and synthesis of a per-O-benzylated 1-C-aryl-heptose glycal and its properties in glycosylations. The experimental procedures and spectroscopic data of all synthesized compounds are given in Chapter 4.
Immature platelet fraction and immature platelet count as novel biomarkers of elevated platelet reactivity in NSTE-ACS patients receiving dual antiplatelet therapy - Supplementary materials
Creators: name: Tomaniak, Mariusz
name: Gumiezna, Karolina
Publisher: name: Zenodo
Year: 2023

description: Supplementary Table 1. Partial Spearman Correlation Analysis between ADP and IPF/IPC for potentially confounding variables.
Supplementary Table 2. Multivariate analysis showing the relation between ADP-induced platelet aggregation and the clinical presentation of ACS after adjustment for potential confounding variables.
Supplementary Table 3. The differences between platelet parameters (IPF, IPC and ADP-induced PA) in groups divided by diabetic status, insulin intake or P2Y12 inhibitor used.
The RAVE catalogue of stellar elemental abundances: first data release
Creators: name: Boeche, C.
name: Siebert, A.
name: Williams, M.
name: de Jong, R. S.
name: Steinmetz, M.
name: Fulbright, J. P.
name: Ruchti, G. R.
name: Bienaymé, O.
name: Bland-Hawthorn, J.
name: Campbell, R.
name: Freeman, K. C.
name: Gibson, B. K.
name: Gilmore, G.
name: Grebel, E. K.
name: Helmi, A.
name: Munari, U.
name: Navarro, J. F.
name: Parker, Q. A.
name: Reid, W.
name: Seabroke, G. M.
name: Siviero, A.
name: Watson, F. G.
name: Wyse, R. F. G.
name: Zwitter, T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present chemical elemental abundances for $36,561$ stars observed by the RAdial Velocity Experiment (RAVE), an ambitious spectroscopic survey of our Galaxy at Galactic latitudes $|$b$|>25^{\circ}$ and with magnitudes in the range 9$
description: 46 pages, 24 figures. AJ accepted
Resting-State Functional Magnetic Resonance Imaging of Motor Networks in Perinatal Stroke
Creators: name: Saunders, Jennifer Kayleigh
Publisher: name: Graduate Studies
Year: 2014
Subjects: subject: Human Development
subject: Medicine and Surgery
subject: Rehabilitation and Therapy
subject: perinatal stroke
subject: functional connectivity
subject: Motor
subject: motor networks
subject: Resting-State fMRI
subject: rs-fMRI
subject: fMRI
subject: Ischemic Stroke
subject: Pediatric
subject: Plasticity
subject: Neuroplasticity
subject: Cerebral Palsy
subject: Motor Function
subject: resting-state functional magnetic resonance imaging

description: Perinatal stroke is a focal brain injury that causes lifelong disability, including hemiparetic cerebral palsy. Arterial and venous strokes can both damage motor pathways. However, they differ in location and timing, potentially leading to distinct mechanisms of developmental plasticity that determine motor outcome. Existing models of post-stroke neuroplasticity lack an understanding of the functional networks that ultimately determine motor function. This study used resting-state functional magnetic resonance imaging to examine motor network functional connectivity patterns in perinatal stroke patients and to determine if there is a relationship between the functional connection strength and motor outcome. Significant differences in motor network connections were observed between stroke patients and healthy control subjects. No significant relationship was observed between functional connection strength and motor outcome scores. The results of this study serve as a foundation to better understand how resting-state functional imaging can assess motor function and the effects of interventional post-stroke therapies.
Sommerfeld's image method in the calculation of van der Waals forces
Creators: name: Souza, Reinaldo de Melo e
name: Kort-Kamp, W. J. M.
name: Sigaud, C.
name: Farina, C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show how the image method can be used together with a recent method developed by C. Eberlein and R. Zietal to obtain the dispersive van der Waals interaction between an atom and a perfectly conducting surface of arbitrary shape. We discuss in detail the case of an atom and a semi- infinite conducting plane. In order to employ the above procedure to this problem it is necessary to use the ingenious image method introduced by Sommerfeld more than one century ago, which is a generalization of the standard procedure. Finally, we briefly discuss other interesting situations that can also be treated by the joint use of Sommerfeld's image technique and Eberlein-Zietal method.
description: To appear in the proceedings of Conference on Quantum Field Theory under the Influence of External Conditions (QFEXT11)
Contact guidance is cell cycle-dependent
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018

description: © 2018 Author(s). Cancer cell migration is essential for metastasis, during which cancer cells move through the tumor and reach the blood vessels. In vivo, cancer cells are exposed to contact guidance and chemotactic cues. Depending on the strength of such cues, cells will migrate in a random or directed manner. While similar cues may also stimulate cell proliferation, it is not clear whether cell cycle progression affects migration of cancer cells and whether this effect is different in random versus directed migration. In this study, we tested the effect of cell cycle progression on contact guided migration in 2D and 3D environments, in the breast carcinoma cell line, FUCCI-MDA-MB-231. The results were quantified from live cell microscopy images using the open source lineage editing and validation image analysis tools (LEVER). In 2D, cells were placed inside 10 μm-wide microchannels to stimulate contact guidance, with or without an additional chemotactic gradient of the soluble epidermal growth factor. In 3D, contact guidance was modeled by aligned collagen fibers. In both 2D and 3D, contact guidance was cell cycle-dependent, while the addition of the chemoattractant gradient in 2D increased cell velocity and persistence in directionally migrating cells, regardless of their cell cycle phases. In both 2D and 3D contact guidance, cells in the G1 phase of the cell cycle outperformed cells in the S/G2 phase in terms of migration persistence and instantaneous velocity. These data suggest that in the presence of contact guidance cues in vivo, breast carcinoma cells in the G1 phase of the cell cycle may be more efficient in reaching the neighboring vasculature.
title: Bei uns am Markte
title: Ein Brief aus Halle (1807) und die Überlieferung von Schleiermachers Charaden
titleType: Subtitle
Creators: name: Sprengel, Peter
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Friedrich Schleiermacher
subject: Rätselgedichte
subject: Textgeschichte
subject: 800 Literatur::830 Deutsche und verwandte Literaturen::830 Literaturen germanischer Sprachen; Deutsche Literatur

description: Welchen Weg nahm die Textgeschichte von Schleiermachers Rätselgedichten zwischen der ersten eigenhändigen Niederschrift ca. 1806 und den ältesten – einer klaren Autorisation ermangelnden, in der Textgestalt stark differierenden – Drucken in den 1820er und 1830er Jahren? In dieser unklaren Sachlage hat die Schleiermacher-Philologie auch eine Abschrift von unbekannter Hand als Textzeugen (von zweifelhaftem Stellenwert) diskutiert, die sich aufgrund des zugehörigen Briefs und eines Handschriftenvergleichs jetzt eindeutig zuordnen und datieren lässt. Sie dokumentiert die Zirkulation der geselligen Gelegenheitsgedichte im Hallenser Kreis 1806/07 und bildet zugleich die Quelle für den zweiten nachweisbaren Druck 1837. Dies sei im Folgenden ausführlich dargelegt und begründet.
description: What path did the textual history of Schleiermacher’s Charades take between the first handwritten transcription around 1806 and the oldest printings in the 1820s and 1830s – which lack a clear authorisation and differ greatly in textual form? In this unclear situation, Schleiermacher philology has also discussed a copy by an unknown hand as a textual witness (of dubious value), which can now be clearly assigned and dated on the basis of the accompanying letter and a comparison of manuscripts. It documents the circulation of the sociable occasional poems in the Hallenser Kreis (Halle Circle) in 1806/07 and at the same time forms the source for the second verifiable print in 1837.
Two-Year Results of Think Health! ¡Vive Saludable!: A Primary Care Weight-Management Trial
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: Adult
Female
Humans
Male
Middle Aged
Time Factors
Weight Reduction Programs

description: © 2018 The Obesity Society Objective: Think Health! ¡Vive Saludable! evaluated a moderate-intensity, lifestyle behavior-change weight-loss program in primary care over 2 years of treatment. Final analyses examined weight-change trajectories by treatment group and attendance. Methods: Adult primary care patients (n = 261; 84% female; 65% black; 16% Hispanic) were randomly assigned to Basic Plus (moderate intensity; counseling by primary care clinician and a lifestyle coach) or Basic (clinician counseling only). Intention-to-treat analyses used all available weight measurements from data collection, treatment, and routine clinical visits. Linear mixed-effects regression models adjusted for treatment site, gender, and age, and sensitivity analyses evaluated treatment attendance and the impact of loss to follow-up. Results: Model-based estimates for 24-month mean (95% CI) weight change from baseline were −1.34 kg (−2.92 to 0.24) in Basic Plus and −1.16 kg (−2.70 to 0.37) in Basic (net difference −0.18 kg [−2.38 to 2.03]; P = 0.874). Larger initial weight loss in Basic Plus was attenuated by a ~0.5-kg rebound at 12 to 16 months. Each additional coaching visit was associated with a 0.37-kg greater estimated 24-month weight loss (P = 0.01). Conclusions: These findings in mostly black and Hispanic female primary care patients suggest that strategies to improve treatment attendance may improve weight loss resulting from moderate-intensity counseling.
Deliverable 3.7 Citizen Science as a communication tool in the Post-Factual Era. Deliverable report of project H2020 NEWSERA (grant agreement No 873125).
Creators: name: Leguina, Leire
name: Magalhães, Joana
name: Tola, Elisabetta
name: Guasch, Blanca
name: Elorza, Ana
name: Lacunza, Izaskun
name: Arias, R
Publisher: name: Zenodo
Year: 2023
Subjects: misinformation, citizen science, trust

description: This deliverable aims at initiating a reflection on how citizen science (CS) can become a science communication tool with potential to tackle misinformation. For this we envisioned to open the discussion with the CS projects enrolled in NEWSERA as pilots, as well as, bring both research and practice experts to enrich the debate and open a new direction in this matter of timely global concern. The reflection process will have two main objectives: i) better understand the nature of misinformation; ii) identify the present and future role of citizen science in this important subject of ethics related to communication. Two workshops were organized and tested with the collaboration of the NEWSERA pilots and invited experts. The content and results are hereby described. Citizens involved in CS projects become important data collectors and producers and can play a key role when it comes to science information and education. In this deliverable we analyze the way that CS projects can contribute to tackling one of the main problems we face nowadays in science communication: misinformation. After a comprehensive reflection on the matter, in a co-creation process with the NEWSERA pilots, partners and other stakeholders such as H2020 SwafS-19 sister projects (for instance, TRESCA and ENJOI) and communication experts, we provide as a main output a set of take-away ideas on how to use data and information in CS projects to help tackling misinformation.
Land- und Viehwirtschaft am Unteren Habur in mittelassyrischer Zeit
Creators: name: Röllig, Wolfgang
Publisher: name: Freie Universität Berlin
Year: 2008
Subjects: subject: Vorderasiatische Archäologie
subject: Syrien
subject: Tall Šēḫ Ḥamad
subject: Dūr-Katlimmu
subject: Keilschrifttexte
subject: Mittelassyrische Zeit
subject: Landwirtschaft
subject: Viehwirtschaft
subject: 900 Geschichte und Geografie::930 Geschichte des Altertums (bis ca. 499), Archäologie::935 Geschichte Mesopotamiens und der iranischen Hochebene bis 637

description: Von den 677 in der Grabungsstelle „Gebäude P“ des Grabungsabschnitts „Tell (Zitadelle)“ registrierten Schriftartefakten in mittelassyrischer Sprache und Schrift (s. Tabelle 04.02 in BATSH 12) werden 363 in vier Bänden (BATSH 4, BATSH 9, BATSH 10 i.V., BATSH 18) ediert. In Verbindung mit dem archäologischen Kontext, der in BATSH 12, Kap. 02, 04, 12 und 18 dokumentiert und interpretiert wird, entsteht ein Bild von der Entstehung der Stadt Dūr-Katlimmu, ihrer Geschichte, Funktion und Bedeutung im 13. Jahrhundert v.Chr. und darüber hinaus. In diesem Band werden 106 Schriftartefakte in mittelassyrischer Sprache in Kopie, Umschrift und Übersetzung ediert. Sie befassen sich mit der Beauftragung von Hirten und deren Abrechnung über Herden von Rindern, Eseln und Kleinvieh, sowie mit den Erträgen von Feldern mit Gerste, Weizen und Sesam, die in diesem ariden Gebiet zum Teil nur mit Bewässerung erreicht werden konnten aber zeitweilig auch durch den Einfall von Feinden oder durch Unwetter bedroht waren. Sie gewähren erstmals Einblicke in die landwirtschaftliche Produktion und Verwaltung der assyrischen Krongüter in der Provinzstadt Dūr-Katlimmu während der Regierungszeiten der Könige Salmanassar I und Tukulti-Ninurta I (1263–1197 v. Chr.).
description: Out of the 677 written artifacts in Middle Assyrian language and script excavated and registered in the section “Gebäude P” of the excavation unit „Tell / Citadel” (Table 04.02 in BATSH 12) 363 will be edited in four volumes: BATSH 4, BATSH 9, BATSH 10 i.p., BATSH 18. Developing a prospect on the formation of the city of Dūr-Katlimmu, its history, function and significance during the 13th c. BC and beyond the archaeological context is recorded and interpreted in BATSH 12, chaps. 02, 04,12, and 18. 106 written artifacts of Middle Assyrian language and script are edited in copy, transcription, and translation in this volume. They are concerned with animal husbandry and farming. Herdsmen are commissioned and need to balance accounts about their flocks after returning. Yields of barley, wheat or sesame vary and are partly dependent on irrigation but are also endangered by storm or hostile actions.
The differential gene expression of CD43 wildtype and knockout macrophages in response to mycobacterial stimulation
Creators: name: Vair, Audra Helena
Publisher: name: University of British Columbia
Year: 2010

description: Previous studies in our lab show CD43 deficient macrophages have reduced binding and uptake of M.tb bacilli but allow increased intracellular bacterial growth within the host macrophage due to decreased TNF‐α production. It was also found that there are two heat‐shock proteins found on the cell surface of M.tb that are capable of binding CD43: Cpn 60.2 and dnaK. The purpose of this study was to determine the intracellular signalling pathways activated by CD43 upon M.tb stimulation and to determine if Cpn 60.2 or dnaK could reproduce these responses. An RNA‐microarray was performed using mRNA isolated from wildtype (CD43 +/+) and gene‐deleted (CD43‐/‐) bone‐marrow derived murine macrophages that had been co‐incubated with one of M.tb, Cpn 60.2 or dnaK. There was a large quantity of differentially regulated genes for each treatment, ranging from 330 to 990. Only 113 of these genes were statistically significant and shared between treatment types, 21 genes down regulated in the knockout compared to the wild type and 92 genes were up regulated in CD43‐/‐ compared to CD43+/+. Pathway analysis of differential gene expression was performed using lists of statistically significant, differentially‐regulated genes, which indicated there were multiple pathways and cellular processes in which several genes were found to be affected by the absence of CD43. The pathways included p38/JNK/Erk MAP kinase signaling functioning, TNF‐α post‐transcriptional control, cytoskeletal remodeling, phagocytosis and apoptosis. Related genes from both the microarray data and interacting genes from pathway‐data associated with TNF‐α and apoptosis were selected to both validate the microarray and possibly determine if changes in TNF‐related regulation could be controlled by CD43. The microarray indicated several genes involved in TNF‐α regulation and apoptosis were differentially expressed in CD43 +/+ and CD43 ‐/‐ macrophages. Quantitative Reverse‐Transcriptase PCR was used on a selected number of these genes. Differential gene regulation was o served in the Q RT‐PCR results; however results conflicted with the microarray. In conclusion, CD43 influences the course of M.tb infection within the macrophage, possibly through the regulation of TNF‐α and apoptosis. There are implications for CD43‐related control of eicosanoid production and cytoskeletal regulation but these observations require further investigation.
The Emergence of Modularity in Biological Systems
Creators: name: Lorenz, Dirk M.
name: Jeng, Alice
name: Deem, Michael W.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: In this review, we discuss modularity and hierarchy in biological systems. We review examples from protein structure, genetics, and biological networks of modular partitioning of the geometry of biological space. We review theories to explain modular organization of biology, with a focus on explaining how biology may spontaneously organize to a structured form. That is, we seek to explain how biology nucleated from among the many possibilities in chemistry. The emergence of modular organization of biological structure will be described as a symmetry-breaking phase transition, with modularity as the order parameter. Experimental support for this description will be reviewed. Examples will be presented from pathogen structure, metabolic networks, gene networks, and protein-protein interaction networks. Additional examples will be presented from ecological food networks, developmental pathways, physiology, and social networks.
description: 54 pages, 25 figures
Identified particles from viscous hydrodynamics
Creators: name: Molnar, Denes
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Identified particle observables from viscous hydrodynamics are sensitive to the fluid-to-particle conversion. Instead of the commonly assumed "democratic" Grad ansatz for phase space corrections $δf$, we utilize corrections calculated from linearized covariant transport theory. Estimates based on a pion-proton system with binary collisions indicate that protons are much closer to equilibrium than pions, significantly affecting the dissipative reduction of differential elliptic flow in Au+Au at RHIC. In addition, we test linear response against fully nonlinear transport for a two-component massless system in a Bjorken scenario. Strikingly, we find that, while linear response accounts well for the dynamical sharing of shear stress, the momentum dependence of phase space corrections is best described by Grad's quadratic ansatz, and not the linear response solution.
description: Quark Matter 2011 contribution - 4 pages, uses IOP style files