cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(500727) Horace Arthur Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Current Celestial Reference Frame Status at X/S and K Bands
Creators: name: Gordon, David
name: de Witt, Aletha
name: Jacobs, Christopher S.
name: Johnson, Megan
name: Hunt, Lucas
Publisher: name: Zenodo
Year: 2022

description: The third realization of the International Celestial Reference Frame, ICRF3, was finalized in June 2018 using VLBI sessions through March 2018. It was accepted by the IAU in August 2018 and became official on Jan. 1, 2019. ICRF3 contains 4536 sources in its X/S catalog and 824 sources in its K band catalog. In the 4 years since the finalization of ICRF3, dedicated astrometric campaigns have been made to maintain, improve and expand the ICRF at X/S and K bands and now four additional years of observations are available. In the northern hemisphere, these campaigns have used the VLBA at both X/S and K bands under the USNO’s VLBA time share allocation. And in the southern hemisphere, the HARTRAO-HOBART26 network has been used at K band. These sessions, as well as the IVS sessions, have added ~20% more sources to the X/S catalog and ~25% more sources to the K band catalog, along with significant reductions in the scaled formal errors. We will present the current state of the X/S and K band CRF catalogs, including the distribution of sources and observations and improvements in the scaled formal errors.
ความพึงพอใจของผู้ปกครองในการจัดประสบการณ์การเรียนรู้ระดับอนุบาลของโรงเรียน ในสังกัดเทศบาลนครปากเกร็ด
Creators: name: สิริกร กาญจนสุนทร
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Learning Experience Provision
Pak Kret Municipality
Parent
Satisfaction
การจัดประสบการณ์การเรียนรู้
ความพึงพอใจ
ผู้ปกครอง
เทศบาลนครปากเกร็ด

description: วารสารพัฒนาการเรียนการสอน, 11, 2, 133-146
(500724) Constance Laura Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Critical coupling to Tamm plasmons
Creators: name: Auguie, Baptiste
name: Bruchhausen, Axel
name: Fainstein, Alejandro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The conditions of critical coupling of light to Tamm plasmons are investigated with comprehensive numerical simulations, highlighting the parameters that maximise absorption of incident light in the metal layer. The asymmetric response in reflection and absorption with respect to the direction of incidence is discussed, the two cases yielding different optimal coupling conditions. These findings are relevant for the design of optimised Tamm structures, particularly in applications such as narrow-band thermal emitters, field-enhanced spectroscopy and refractive-index sensing.
Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders
Creators: name: Zylka, M.J.
name: Jiménez, J.A.
Publisher: name: BioMed Central Ltd
Year: 2021

description: Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal studies that are difficult to replicate, potentially undermining the validity of results. These concerns have prompted funding agencies and academic journals to implement more rigorous standards in an effort to increase reproducibility in research. However, these standards fail to address a major source of variability in rodent research brought on by the “litter effect,” the fact that rodents from the same litter are phenotypically more similar to one other than rodents from different litters of the same strain. We show that the litter effect accounts for 30–60% of the variability associated with commonly studied phenotypes, including brain, placenta, and body weight. Moreover, we show how failure to control for litter-to-litter variation can mask a phenotype in Chd8V986*/+ mice that model haploinsufficiency of CHD8, a high-confidence autism gene. Thus, if not properly controlled, the litter effect has the potential to negatively influence rigor and reproducibility of NDD research. While efforts have been made to educate scientists on the importance of controlling for litter effects in previous publications, our analysis of the recent literature (2015–2020) shows that the vast majority of NDD studies focused on genetic risks, including mutant mouse studies, and environmental risks, such as air pollution and valproic acid exposure, do not correct for litter effects or report information on the number of litters used. We outline best practices to help scientists minimize the impact of litter-to-litter variability and to enhance rigor and reproducibility in future NDD studies using rodent models.
Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury
Creators: name: Loo, L.
name: Simon, J.M.
name: Zylka, M.J.
name: Taylor-Blake, B.
name: Niehaus, J.K.
Publisher: name: Cell Press
Year: 2021

description: Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal inflammation has not been determined. Guided by single-cell RNA sequencing (scRNA-seq), we found that MRC1+ spinal cord macrophages proliferated and upregulated the anti-inflammatory mediator Cd163 in mice following superficial injury (SI; nerve intact), but this response was blunted in nerve-injured animals. Depleting spinal macrophages in SI animals promoted microgliosis and caused mechanical hypersensitivity to persist. Conversely, expressing Cd163 in spinal macrophages increased Interleukin 10 expression, attenuated micro- and astrogliosis, and enduringly alleviated mechanical and thermal hypersensitivity in nerve-injured animals. Our data indicate that MRC1+ spinal macrophages actively restrain glia to limit neuroinflammation and resolve mechanical pain following a superficial injury. Moreover, we show that spinal macrophages from nerve-injured animals mount a dampened anti-inflammatory response but can be therapeutically coaxed to promote long-lasting recovery of neuropathic pain.
Ultra-precise astrometry with the next generation of radio instruments
Creators: name: Dodson, Richard
name: Rioja, Maria
Publisher: name: Zenodo
Year: 2022

description: We are at the cusp of a generational shift in the power of radio interferometers, with both the SKA and ngVLA planning for exciting new and powerful instruments. These will be used in conjunction with other radio telescopes to provide VLBI with an order of magnitude greater sensitivity. Furthermore, the new frequencies that will be covered will allow enhanced VLBI observations of sources that can only be observed at high frequencies (e.g. various maser lines) or low frequencies (e.g. pulsars slightly misaligned with our line of sight).
 We have been exploring the implications of these new instruments, as sensitivity alone will not improve over the current astrometric limits - these being systematic. Traditional techniques for differential phase referencing will not be able to significantly overcome the systematic limits, nor extend the current moderate range of frequencies where such methods can be expected to work.
 Fortunately, new methods such as Source/Frequency Phase Referencing and/or MultiView Astrometry both reduce the systematic limits and extend the range of operating frequencies. Preliminary steps have been taken to confirm that these new methods will deliver on their promise; future applications that make full use of these capabilities will allow for major improvements in the astrophysical understanding of our Universe.
(500726) Emma Mary Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Planting colourings silently
Creators: name: Bapst, Victor
name: Coja-Oghlan, Amin
name: Efthymiou, Charilaos
Publisher: name: arXiv
Year: 2014
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 05C80

description: Let $k\geq3$ be a fixed integer and let $Z_k(G)$ be the number of $k$-colourings of the graph $G$. For certain values of the average degree, the random variable $Z_k(G(n,m))$ is known to be concentrated in the sense that $\frac1n(\ln Z_k(G(n,m))-\ln E[Z_k(G(n,m))])$ converges to $0$ in probability [Achlioptas and Coja-Oghlan: FOCS 2008]. In the present paper we prove a significantly stronger concentration result. Namely, we show that for a wide range of average degrees, $\frac1ω(\ln Z_k(G(n,m))-\ln E[Z_k(G(n,m))])$ converges to $0$ in probability for any diverging function $ω=ω(n)\to\infty$. For $k$ exceeding a certain constant $k_0$ this result covers all average degrees up to the so-called condensation phase transition, and this is best possible. As an application, we show that the experiment of choosing a $k$-colouring of the random graph $G(n,m)$ uniformly at random is contiguous with respect to the so-called "planted model".
การพัฒนาชุดทดลองเรื่องปรากฏการณ์โฟโตอิเล็กทริก รายวิชา PHY 224 ปฏิบัติการฟิสิกส์ 2
Creators: name: ปรียา อนุพงษ์องอาจ
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Photoelectric Effect
ปรากฏการณ์โฟโตอิเล็กทริก

description: วารสารพัฒนาการเรียนการสอน, 11, 2, 147-155
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
Creators: name: Taylor-Blake, B.
name: Fragola, G.
name: Chronister, W.D.
name: Mabb, A.M.
name: Niehaus, J.K.
name: Li, Z.
name: Zylka, M.J.
name: Simon, J.M.
name: McConnell, M.J.
name: Yuan, H.
name: Mao, H.
Publisher: name: Nature Research
Year: 2020

description: Topoisomerase 1 (TOP1) relieves torsional stress in DNA during transcription and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal functions. To evaluate how loss of Top1 affected neurons in vivo, we conditionally deleted (cKO) Top1 in postmitotic excitatory neurons in the mouse cerebral cortex and hippocampus. Top1 cKO neurons develop properly, but then show biased transcriptional downregulation of long genes, signs of DNA damage, neuroinflammation, increased poly(ADP-ribose) polymerase-1 (PARP1) activity, single-cell somatic mutations, and ultimately degeneration. Supplementation of nicotinamide adenine dinucleotide (NAD+) with nicotinamide riboside partially blocked neurodegeneration, and increased the lifespan of Top1 cKO mice by 30%. A reduction of p53 also partially rescued cortical neuron loss. While neurodegeneration was partially rescued, behavioral decline was not prevented. These data indicate that reducing neuronal loss is not sufficient to limit behavioral decline when TOP1 function is disrupted.
ประสิทธิผลของการใช้กระบวนการถอดความรู้ด้านเทคนิคการเรียนการสอนที่เน้นผู้เรียนเป็นสำคัญ: กรณีศึกษา กลุ่มมนุษยศาสตร์ และสังคมศาสตร์ มหาวิทยาลัยรังสิต
Creators: name: อารีรัตน์ แย้มเกษร
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Humanities and Social Sciences
student-centered teaching
tacit knowledge method
การถอดความรู้
การสอนที่เน้นผู้เรียนเป็นสำคัญ
มนุษยศาสตร์และสังคมศาสตร์

description: วารสารพัฒนาการเรียนการสอน, 11, 2, 156-169
Coalescence Model for Crumpled Globules Formed in Polymer Collapse
Creators: name: Bunin, Guy
name: Kardar, Mehran
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: The rapid collapse of a polymer, due to external forces or changes in solvent, yields a long-lived `crumpled globule.' The conjectured fractal structure shaped by hierarchical collapse dynamics has proved difficult to establish, even with large simulations. To unravel this puzzle, we study a coarse-grained model of in-falling spherical blobs that coalesce upon contact. Distances between pairs of monomers are assigned upon their initial coalescence, and do not `equilibrate' subsequently. Surprisingly, the model reproduces quantitatively the dependence of distance on segment length, suggesting that the slow approach to scaling is related to the wide distribution of blob sizes.
Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life
Creators: name: Zylka, M.J.
name: Ptacek, T.S.
name: Tuttle, A.H.
name: Schmid, R.S.
name: Moy, S.S.
name: Simon, J.M.
name: Jiménez, J.A.
Publisher: name: BioMed Central Ltd
Year: 2020

description: Background: Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior at different stages of life is unknown. Methods: We generated a mutant mouse line with an ASD-linked loss-of-function mutation in Chd8 (V986; stop codon mutation). We examined the behavior of Chd8 mutant mice along with transcriptional changes in the cerebral cortex as a function of age, with a focus on one embryonic (E14.5) and three postnatal ages (1, 6, and 12 months). Results: Chd8 V986/+ mutant mice displayed macrocephaly, reduced rearing responses and reduced center time in the open field, and enhanced social novelty preference. Behavioral phenotypes were more evident in Chd8 V986/+ mutant mice at 1 year of age. Pup survival was reduced in wild-Type x Chd8 V986/+ crosses when the mutant parent was female. Transcriptomic analyses indicated that pathways associated with synaptic and neuronal projections and sodium channel activity were reduced in the cortex of embryonic Chd8 V986/+ mice and then equalized relative to wild-Type mice in the postnatal period. At 12 months of age, expression of genes associated with endoplasmic reticulum (ER) stress, chaperone-mediated protein folding, and the unfolded protein response (UPR) were reduced in Chd8 V986/+ mice, whereas genes associated with the c-MET signaling pathway were increased in expression. Limitations: It is unclear whether the transcriptional changes observed with age in Chd8 V986/+ mice reflect a direct effect of CHD8-regulated gene expression, or if CHD8 indirectly affects the expression of UPR/ER stress genes in adult mice as a consequence of neurodevelopmental abnormalities. Conclusions: Collectively, these data suggest that UPR/ER stress pathways are reduced in the cerebral cortex of aged Chd8 V986/+ mice. Our study uncovers neurodevelopmental and age-related phenotypes in Chd8 V986/+ mice and highlights the importance of controlling for age when studying Chd8 haploinsufficient mice.
(500728) Alfred Noel Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
حاشية الحافظ جلال الدين السيوطي على تفسير القاضي البيضاوي - نواهد الأبكار وشوارد الأفكار من أول الجزء الثاني إلى آخر سورة البقرة - دراسة وتحقيق
Creators: name: Abouzeid, Mohamed
Publisher: name: figshare
Year: 2020
Subjects: subject: 220499 Religion and Religious Studies not elsewhere classified
subject: FOS: Philosophy, ethics and religion
subject: 130211 Religion Curriculum and Pedagogy
subject: FOS: Educational sciences
subject: 200526 Stylistics and Textual Analysis
subject: FOS: Languages and literature

description: بحث مقدم إلى قسم التفسير وعلوم القرآن بكلية أصول الدين - جامعة الأزهر بالقاهرة لنيل درجة (العالمية) الدكتوراه والمقدمة من الطالب / محمد شرعي سليمان أبو زيد وموضوعها حاشية الحافظ جلال الدين السيوطي على تفسير القاضي البيضاوي من أول قوله تعالي "سيقول السفهاء من الناس ما ولاهم عن قبلتهم التى كانوا عليها أول الجزء الثاني من سورة البقرة دراسة وتحقيق.Dissertation presented to the Department of Interpretation and Qur’an Sciences at the College of Fundamentals of Religion - Al-Azhar University in Cairo for a (global) doctorate degree submitted by the student / Muhammad Shari Sulaiman Abu Zaid and the subject of it is Hafiz Jalal al-Din al-Suyuti's commentary on Judge al-Baydawi’s commentary from the beginning of the Almighty saying: On their Qiblah, which they were upon in the beginning of the second part of Surat Al-Baqara, study and investigation
Prenatal treatment path for angelman syndrome and other neurodevelopmental disorders
Creators: name: Zylka, M.
Publisher: name: John Wiley and Sons Inc.
Year: 2020

description: Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by mutation or deletion of the maternally inherited UBE3A allele. These pathogenic mutations lead to loss of maternal UBE3A expression in neurons. Antisense oligonucleotides and gene therapies are in development, which activate the intact but epigenetically silenced paternal UBE3A allele. Preclinical studies indicate that treating during the prenatal period could greatly reduce the severity of symptoms or prevent AS from developing. Genetic tests can detect the chromosome 15q11-q13 deletion that is the most common cause of AS. New, highly sensitive noninvasive prenatal tests that take advantage of single-cell genome sequencing technologies are expected to enter the clinic in the coming years and make early genetic diagnosis of AS more common. Efforts are needed to identify fetuses and newborns with maternal 15q11-q13 deletions and to phenotype these babies relative to neurotypical controls. Clinical and parent observations suggest AS symptoms are detectable in infants, including reports of problems with feeding and motor function. Quantitative phenotypes in the 0- to 1-year age range will permit a more rapid assessment of efficacy when future treatments are administered prenatally or shortly after birth. Although prenatal therapies are currently not available for AS, prenatal testing combined with prenatal treatment has the potential to revolutionize how clinicians detect and treat babies before they are symptomatic. This pioneering prenatal treatment path for AS will lay the foundation for treating other syndromic neurodevelopmental disorders. Autism Res 2020, 13: 11–17. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay summary: Prenatal treatment could benefit expectant parents whose babies test positive for the chromosome microdeletion that causes Angelman syndrome (AS). Prenatal treatment is predicted to have better outcomes than treating after symptoms develop and may even prevent AS altogether. This approach could generally be applied to the treatment of other syndromic neurodevelopmental disorders.
(500725) Ernest Harold Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
STROBE checklist for ASSOCIATION OF URIC ACID AND URIC ACID TO CREATININE RATIO IN ACUTE RENAL FAILURE AND CHRONIC RENAL FAILURE
Creators: name: Dhongade, Tejaswini
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310101
subject: Analytical biochemistry

description: STROBE checklist for ASSOCIATION OF URIC ACID AND URIC ACID TO CREATININE RATIO IN ACUTE RENAL FAILURE AND CHRONIC RENAL FAILURE
Optimal sensor placement for active flow control with deep reinforcement learning
Creators: name: Krogmann, Tom
Publisher: name: Zenodo
Year: 2023
Subjects: Active flow control, reinforcement learning, deep reinforcement learning, optimal sensor placement, CFD, machine learning, deep learning, fluidic pinball, attention, clustering, random forest, proximal policy optimization

description: Report on investigation of 3 optimal sensor placement methods for active flow control of the fluidic pinball with deep reinforcement learning. Results have shown that the attention mechanism effectively reduces the number of sensors from 476 to 7 without losing performance, thereby identifying optimal sensors directly in the DRL optimization loop.
Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice
Creators: name: Bartsch, V.B.
name: Zylka, M.J.
name: Lord, J.S.
name: Diering, G.H.
Publisher: name: Blackwell Publishing Ltd
Year: 2020

description: Genome-wide association studies linked diacylglycerol kinase eta and iota to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized female mice lacking Dgkh alone, Dgki alone, and double Dgkh/Dgki-knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survived to weaning when raised by wild-type (WT) females. Poor survival under the care of dKO mothers was unrelated to pup genotype. Moreover, pups from dKO dams survived when fostered by WT dams, suggesting the poor survival rate of dKO-raised litters was related to impaired maternal care by dKO dams. Nest building was similar between WT and dKO dams; however, some dKO females failed to retrieve any pups in a retrieval assay. Pups raised by dKO dams had smaller or absent milk spots and reduced weight, indicative of impaired nursing. Unlike WT females, postpartum dKO females showed erratic, panicked responses to cage disturbances. Virgin dKO females showed behavioral signs of anxiety and mania, which were not seen in mice lacking either Dgkh or Dgki alone. Our research indicates that combined deletion of Dgkh and Dgki impairs maternal behavior in the early postpartum period, and suggests female dKO mice model symptoms of mania and anxiety.
Graviton Amplitudes from Collinear Limits of Gauge Amplitudes
Creators: name: Stieberger, Stephan
name: Taylor, Tomasz R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We express all tree-level graviton amplitudes in Einstein's gravity as the collinear limits of a linear combination of pure Yang-Mills amplitudes in which each graviton is represented by two gauge bosons, each of them carrying exactly one half of graviton's momentum and helicity.
description: 7 pages, harvmac
The Hidden Regions: Astrometry in the Near Infrared
Creators: name: Hobbs, David
Publisher: name: Zenodo
Year: 2022

description: Our Galaxy contains many different types of stars and planets, interstellar gas and dust, and dark matter. These components are widely distributed in age, reflecting their formation history, and in space, reflecting their birth place and subsequent motion.Objects in the Galaxy move in a variety of orbits that are determined by the gravitational force, and have complex distributions of different stellar types, reflecting star formation and gas-accretion history. Understanding all these aspects in one coherent picture is being partially achieved by Gaia, which surveys around 1% of the Galaxy and is still ongoing today. However muchmore could be done by using Near InfraRed light to peer through the dust and gas to reveal the hidden regions of the Galaxy.
 A new all-sky Near InfraRed astrometric mission will expand and improve on the science of Gaia using basic astrometry. Near InfraRed astrometry is crucial for penetrating obscured regions and for observing intrinsically red objects. The new mission is aimed at surveying around 10-12 billion stars of the Galaxy, revealing important new regions obscured by interstellar gas and dust while also improving on the accuracy of the previous results from Gaia. There is no single science case to point to, instead the mission will explore the Galaxy, particularly the hidden regions, to reveal nature's true complexity and beauty in action.
 In 2019 ESA announced the next planning cycle for their long term Science Programme, called Voyage 2050. The program called for White Papers outlining new ideas for future space mission themes. In June 2021 Voyage 2050 finally set sail, with ESA having chosen its future science mission themes. Our proposal on All-Sky Visible and Near Infrared Space Astrometry has been selected as one of two possible themes for a future Large category mission for ESA or as a Medium class mission with international partners. This talk will give an update on the science goals, the mission design and its current status.
(500720) Alfred Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Radiation-induced re-emission in a 2D electron system
Creators: name: Iñarrea, Jesus
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent experiments on re-emission of radiation and magnetotransport in photoexcited two-dimensional electron systems are theoretically analyzed. These experiments have concluded that there exists a strong correlation between the re-emitted radiation and the radiation-driven current through the sample. We study these remarkable experimental results using the radiationdriven electron orbit model. According to it, two-dimensional electrons under a magnetic field move back and forth driven by radiation. Therefore, they behave as oscillating dipoles re-emitting part of the radiation previously absorbed. Then, this theory would explain in a simple way the experimental results.
description: 6 pages, 6 figures
(500722) Frederick George Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Strobilurin fungicides in house dust: is wallboard a source?
Creators: name: Phillips, A.L.
name: Hoffman, K.
name: Hammel, S.C.
name: Cooper, E.M.
name: Stapleton, H.M.
name: Zylka, M.J.
name: Rushing, R.
Publisher: name: Springer Nature
Year: 2020

description: Strobilurin fungicides are used primarily in fruits and vegetables, but recently, a patent was issued for one strobilurin fungicide, azoxystrobin, in mold-resistant wallboard. This raises concerns about the potential presence of these chemicals in house dust and potential exposure indoors, particularly in young children. Furthermore, recent toxicological studies have suggested that strobilurins may cause neurotoxicity. Currently, it is not clear whether or not azoxystrobin applications in wallboard lead to exposures in the indoor environments. The purpose of this study was to determine if azoxystrobin, and related strobilurins, could be detected in house dust. We also sought to characterize the concentrations of azoxystrobin in new wallboard samples. To support this study, we collected and analyzed 16 new dry wall samples intentionally marketed for use in bathrooms to inhibit mold. We then analyzed 188 house dust samples collected from North Carolina homes in 2014–2016 for azoxystrobin and related strobilurins, including pyraclostrobin, trifloxystrobin, and fluoxastrobin using liquid chromatography tandem mass spectrometry. Detection frequencies for azoxystrobin, pyraclostrobin, trifloxystrobin, and fluoxastrobin ranged from 34–87%, with azoxystrobin being detected most frequently and at the highest concentrations (geometric mean = 3.5 ng/g; maximum = 10,590 ng/g). Azoxystrobin was also detected in mold-resistant wallboard samples, primarily in the paper covering where it was found at concentrations up to 88.5 µg/g. Cumulatively, these results suggest that fungicides present in wallboard may be migrating to the indoor environment, leading to exposure in the residences that would constitute a separate exposure pathway independent of dietary exposures.
Ab-initio pulsar magnetosphere: three-dimensional particle-in-cell simulations of oblique pulsars
Creators: name: Philippov, Alexander A.
name: Spitkovsky, Anatoly
name: Cerutti, Benoit
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present first-principles relativistic particle-in-cell simulations of the oblique pulsar magnetosphere with pair formation. The magnetosphere starts to form with particles extracted from the surface of the neutron star. These particles are accelerated by surface electric fields and emit photons capable of producing electron-positron pairs. We inject secondary pairs at locations of primary energetic particles, whose energy exceeds the threshold for pair formation. We find solutions that are close to the ideal force-free magnetosphere, with the Y-point and current sheet. Solutions with obliquities $\lt 40^{\circ}$ do not show pair production in the open field line region, because the local current density along magnetic field is below the Goldreich-Julian value. The bulk outflow in these solutions is charge separated, and pair formation happens in the current sheet and return current layer only. Solutions with higher inclinations show pair production in the open field line region, with high multiplicity of the bulk flow and the size of pair-producing region increasing with inclination. We observe the spin-down of the star to be comparable to MHD model predictions. The magnetic dissipation in the current sheet ranges between 20% for the aligned rotator and 3% for the orthogonal rotator. Our results suggest that for low obliquity neutron stars with suppressed pair formation at the light cylinder, the presence of phenomena related to pair activity in the bulk of the polar region, e.g., radio emission, may crucially depend on the physics beyond our simplified model, such as the effects of curved space-time or multipolar surface fields.
description: 7 pages, 5 figures, submitted to ApJLetters
Time-Periodic Solutions of Driven-Damped Trimer Granular Crystals
Creators: name: Charalampidis, E. G.
name: Li, F.
name: Chong, C.
name: Yang, J.
name: Kevrekidis, P. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: In this work, we consider time-periodic structures of trimer granular crystals consisting of alternate chrome steel and tungsten carbide spherical particles yielding a spatial periodicity of three. The configuration at the left boundary is driven by a harmonic in-time actuation with given amplitude and frequency while the right one is a fixed wall. Similar to the case of a dimer chain, the combination of dissipation, driving of the boundary, and intrinsic nonlinearity leads to complex dynamics. For fixed driving frequencies in each of the spectral gaps, we find that the nonlinear surface modes and the states dictated by the linear drive collide in a saddle-node bifurcation as the driving amplitude is increased, beyond which the dynamics of the system become chaotic. While the bifurcation structure is similar for solutions within the first and second gap, those in the first gap appear to be less robust. We also conduct a continuation in driving frequency, where it is apparent that the nonlinearity of the system results in a complex bifurcation diagram, involving an intricate set of loops of branches, especially within the spectral gap. The theoretical findings are qualitatively corroborated by the experimental full-field visualization of the time-periodic structures.
description: 13 pages, 8 figures, 2 tables
(500723) Alice Mary Tanner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Spectro-astrometry with Photonic Lanterns
Creators: name: Kim, Yoo Jung
Publisher: name: Zenodo
Year: 2022

description: New frontiers of astronomical science push the imaging capabilities of modern adaptive optics (AO)-equipped telescopes. Examples included studies of planet formation through high-contrast imaging studies of exoplanets and circumstellar disks, and studies of accretion and outflows in circumstellar environments. However, precision measurement at the diffraction limit is made challenging by time-varying residual aberrations in AO-corrected wavefronts. Photonic lanterns are a novel technology with the potential to enable new capabilities in precision measurement at the diffraction limit through the exploitation of their novel spatial filtering and coherence properties. We present the potential sensitivity of photonic-lantern spectrometers for determining two-dimensional spectroastrometric signals for emission-line sources as a function of AO residual wavefront error.
Improving pain assessment in mice and rats with advanced videography and computational approaches
Creators: name: Abdus-Saboor, I.
name: Fried, N.T.
name: Chamessian, A.
name: Zylka, M.J.
Publisher: name: Lippincott Williams and Wilkins
Year: 2020

description: Accurately measuring pain in humans and rodents is essential to unravel the neurobiology of pain and discover effective pain therapeutics. However, given its inherently subjective nature, pain is nearly impossible to objectively assess. In the clinic, patients can articulate their pain experience using questionnaires and pain scales but self-reporting can be unreliable due to various psychological and social influences or difficulties for some patients to verbalize their experience (eg, infants, toddlers, and those with neurodevelopmental disorders). At the bench, these challenges are even more daunting as researchers rely on the behaviors of rodents to measure pain or pain relief. Given this, there is a growing realization among pain researchers, clinicians, and funding entities that these traditional approaches of assessing pain in rodents may be flawed. Importantly, these flaws may have contributed to several failed drugs that initially showed promise as analgesics and point toward inconsistencies in our understanding of basic pain neurobiology.
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA
Creators: name: Wolter, J.M.
name: Oztemiz, B.
name: Fragola, G.
name: Simon, J.M.
name: Zylka, M.J.
name: Krantz, J.L.
name: Stein, J.L.
name: Mao, H.
name: Bazick, H.O.
Publisher: name: Nature Research
Year: 2020

description: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a mutation or deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited UBE3A allele is silenced in cis by a long non-coding RNA called UBE3A-ATS. Here, as part of a systematic screen, we found that Cas9 can be used to activate ('unsilence') paternal Ube3a in cultured mouse and human neurons when targeted to Snord115 genes, which are small nucleolar RNAs that are clustered in the 3′ region of Ube3a-ATS. A short Cas9 variant and guide RNA that target about 75 Snord115 genes were packaged into an adeno-associated virus and administered to a mouse model of AS during the embryonic and early postnatal stages, when the therapeutic benefit of restoring Ube3a is predicted to be greatest1,2. This early treatment unsilenced paternal Ube3a throughout the brain for at least 17 months and rescued anatomical and behavioural phenotypes in AS mice. Genomic integration of the adeno-associated virus vector into Cas9 target sites caused premature termination of Ube3a-ATS at the vector-derived polyA cassette, or when integrated in the reverse orientation, by transcriptional collision with the vector-derived Cas9 transcript. Our study shows that targeted genomic integration of a gene therapy vector can restore the function of paternally inherited UBE3A throughout life, providing a path towards a disease-modifying treatment for a syndromic neurodevelopmental disorder.
Nature or nurture of coplanar Tatooines: the aligned circumbinary Kuiper belt analogue around HD 131511
Creators: name: Kennedy, Grant M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A key discovery of the Kepler mission is of the circumbinary planets known as "Tatooines", which appear to be well aligned with their host stars' orbits. Whether this alignment is due to initially coplanar circumbinary planet-forming discs (i.e. nature), or subsequent alignment of initially misaligned discs by warping the inner disc or torquing the binary (i.e. nurture), is not known. Tests of which scenario dominates may be possible by observing circumbinary Kuiper belt analogues ("debris discs"), which trace the plane of the primordial disc. Here, the 140 au diameter circumbinary debris disc around HD 131511 is shown to be aligned to within 10$^\circ$ of the plane of the near edge-on 0.2 au binary orbit. The stellar equator is also consistent with being in this plane. If the primordial disc was massive enough to pull the binary into alignment, this outcome should be common and distinguishing nature versus nurture will be difficult. However, if only the inner disc becomes aligned with the binary, the HD 131511 system was never significantly misaligned. Given an initial misalignment, the $\sim$Gyr main-sequence lifetime of the star allows secular perturbations to align the debris disc out to 100 au at the cost of an increased scale height. The observed debris disc scale height limits any misalignment to less than 25$^\circ$. With only a handful known, many more such systems need to be characterised to help test whether the alignment of circumbinary planets is nature or nurture.
description: Accepted to MNRAS Letters
Deal or no Deal?
Creators: name: Schuchardt, Anne
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Deutschland
subject: Open Access
subject: Wahrnehmung durch Wissenschaftler
subject: DEAL-Transformationsverträge
subject: leitfadengestütztes Interview
subject: Qualitative Forschung
subject: 020 Bibliotheks- und Informationswissenschaften

description: Gegenstand dieser Arbeit ist die Untersuchung der Wahrnehmung von Open Access und der DEAL-Transformationsverträge durch WissenschaftlerInnen an deutschen Hochschulen. Hierfür wurden leitfadengestützte Interviews geführt. Die Ergebnisse zeigen, dass Open Access von den befragten Forschenden mehrheitlich als bedeutungsvolle Thematik wahrgenommen wird. Hierbei spielen die idealistische Auffassung, dass öffentlich finanzierte Forschung frei zugänglich sein sollte sowie die Hoffnung einer besseren Wahrnehmung eigener Veröffentlichungen eine Rolle. Gleichzeitig konnte festgestellt werden, dass die Wahrnehmung des DEALs durch WissenschaftlerInnen noch relativ gering ausgeprägt war. Wenn die DEAL- Transformationsverträge bereits wahrgenommen wurden, fielen die Reaktionen darauf positiv aus und eine Veröffentlichung in einem Journal, das Teil der DEAL-Verträge ist, wurde als gute Option zum Publizieren gesehen. Dabei war für die Befragten speziell die Finanzierungssicherheit ein entscheidender Faktor. Gerade WissenschaftlerInnen auf Qualifizierungsstellen betonten das Problem der finanziellen Unsicherheit im Bereich der APCs beim Open-Access-Publizieren. Die DEAL-Transformationsverträge sorgen für ein sorgenfreieres Publizieren im Bereich der Open-Access-Veröffentlichung, auch weil die entsprechenden Journals von Wiley und Springer den gewohnten Qualitätsstandards entsprechen und in der Community seit Jahren etabliert sind.
Precision Galactic Archaeology: Revealing the Milky Way's Engines through the Statistical Alignments of Stars
Creators: name: Ting, Yuan Sen
Publisher: name: Zenodo
Year: 2022

description: The unprecedented precise astrometry of Gaia eDR3 has propelled the study of the Milky Way to enter a phase akin to where cosmology was two decades ago. Classically, the study of the Milky Way focuses mainly on blockbuster events, such as Galactic streams and dynamical resonances. However, these blockbuster events are most likely just showing us the tip of the iceberg. Much of the subgrid physics of the Milky Way only manifests itself through the subtle alignments of stars. Fortunately, such statistical patterns of the Milky Way are readily perceivable with the massive astrometry surveying of stars that densely cover the Milky Way. In this talk, I will discuss how we can extract subtle phase space and chemical fluctuations in the Milky Way and how these fluctuations present enormous new opportunities to reveal the invisible engines that drive the formation of stars and galaxy evolution.
The Structure of Dark Molecular Gas in the Galaxy - I: A Pilot Survey for 18-cm OH Emission Towards $l \approx 105^°, b \approx +1^°$
Creators: name: Allen, Ronald J.
name: Hogg, David E.
name: Engelke, Philip D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the first results from a survey for 1665, 1667, and 1720 MHz OH emission over a small region of the Outer Galaxy centered at $l \approx 105.0°, b \approx +1.0°$ . This sparse, high-sensitivity survey ($ΔTa \approx ΔTmb \approx 3.0 - 3.5$ mK rms in 0.55 km/s channels), was carried out as a pilot project with the Green Bank Telescope (GBT, FWHM $\approx 7.6'$) on a 3 X 9 grid at $0.5°$ spacing. The pointings chosen correspond with those of the existing $^{12}$CO(1-0) CfA survey of the Galaxy (FWHM $\approx 8.4'$). With 2-hr integrations, 1667 MHz OH emission was detected with the GBT at $\gtrsim 21$ of the 27 survey positions ($\geq 78\%$ ), confirming the ubiquity of molecular gas in the ISM as traced by this spectral line. With few exceptions, the main OH lines at 1665 and 1667 MHz appear in the ratio of 5:9 characteristic of LTE at our sensitivity levels. No OH absorption features are recorded in the area of the present survey, in agreement with the low levels of continuum background emission in this direction. At each pointing the OH emission appears in several components extending over a range of radial velocity and coinciding with well-known features of Galactic structure such as the Local Arm and the Perseus Arm. In contrast, little CO emission is seen in the survey area; less than half of the $\gtrsim 50$ identified OH components show detectable CO at the CfA sensitivity levels, and these are generally faint. There are no CO profiles without OH emission. With few exceptions, peaks in the OH profiles coincide with peaks in the GBT HI spectra (obtained concurrently, FWHM $8.9'$), although the converse is not true. We conclude that main-line OH emission is a promising tracer for the "dark molecular gas" in the Galaxy discovered earlier in Far-IR and gamma-ray emission. Further work is needed to establish the quantitative details of this connection.
description: 24 pages, 10 figures, accepted for publication in the Astronomical Journal on 1/30/15