cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sonnenfleckenzeichnung Nr. 254.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.11.2012, 11:00, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2012

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
The connectome of an insect brain
Creators: name: Winding, Michael
name: Pedigo, Benjamin
name: Barnes, Christopher
name: Patsolic, Heather
name: Park, Youngser
name: Kazimiers, Tom
name: Fushiki, Akira
name: Andrade, Ingrid
name: Khandelwal, Avinash
name: Valdes-Aleman, Javier
name: Li, Feng
name: Randel, Nadine
name: Barsotti, Elizabeth
name: Correia, Ana
name: Fetter, Richard
name: Hartenstein, Volker
name: Priebe, Carey
name: Vogelstein, Joshua
name: Cardona, Albert
name: Zlatic, Marta
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022

description: Brains contain networks of interconnected neurons, so knowing the network architecture is essential for understanding brain function. We therefore mapped the synaptic-resolution connectome of an insect brain ( Drosophila larva) with rich behavior, including learning, value-computation, and action-selection, comprising 3,013 neurons and 544,000 synapses. We characterized neuron-types, hubs, feedforward and feedback pathways, and cross-hemisphere and brain-nerve cord interactions. We found pervasive multisensory and interhemispheric integration, highly recurrent architecture, abundant feedback from descending neurons, and multiple novel circuit motifs. The brain’s most recurrent circuits comprised the input and output neurons of the learning center. Some structural features, including multilayer shortcuts and nested recurrent loops, resembled powerful machine learning architectures. The identified brain architecture provides a basis for future experimental and theoretical studies of neural circuits. One-Sentence Summary We generated a synaptic-resolution brain connectome and characterized its connection types, neuron types, and circuit motifs.
P.Oxy. XVIII 2161. Aeschylus, Diktyoulkoi
Creators: name: Papyri, Oxyrhynchus
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 200305 Latin and Classical Greek Languages
subject: FOS: Languages and literature

description: Reproduction requests: https://www.ees.ac.uk/reproduction-requests-and-fees
The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Activates the Akt Signaling Pathway
Creators: name: Tomlinson, C. C.
name: Damania, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been implicated in Kaposi's sarcoma, as well as in primary effusion lymphoma and multicentric Castleman's disease. The K1 protein of KSHV has been shown to induce cellular transformation and focus formation and to deregulate B-lymphocyte signaling pathways by functionally mimicking the activated B-cell receptor complex. Here we show that expression of K1 in B lymphocytes targets the phosphatidylinositol-3 kinase pathway, leading to the activation of the Akt kinase and the inhibition of the phosphatase PTEN. We also demonstrate that activation of Akt by the K1 protein leads to the phosphorylation and inhibition of members of the forkhead (FKHR) transcription factor family, which are key regulators of cell cycle progression and apoptosis. We demonstrate that K1 can inhibit apoptosis induced by the FKHR proteins and by stimulation of the Fas receptor. Our observations suggest that the K1 viral protein promotes cell survival pathways and may contribute to KSHV pathogenesis by preventing virally infected cells from undergoing apoptosis prematurely.
Sonnenfleckenzeichnung Nr. 256.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.12.2012, 11:00, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2012

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 2.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Macroscopic excitations in confined Bose-Einstein condensates, searching for quantum turbulence
Creators: name: Zamora-Zamora, R.
name: Adame-Arana, O.
name: Romero-Rochín, V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We present a survey of macroscopic excitations of harmonically confined Bose-Einstein condensates (BEC), described by Gross-Pitaevskii (GP) equation, in search of routes to develop quantum turbulence. These excitations can all be created by phase imprinting techniques on an otherwise equilibrium Bose-Einstein condensate. We analyze two crossed vortices, two parallel anti-vortices, a vortex ring, a vortex with topological charge Q = 2, and a tangle of 4 vortices. Since GP equation is time-reversal invariant, we are careful to distinguish time intervals in which this symmetry is preserved and those in which rounding errors play a role. We find that the system tends to reach stationary states that may be widely classified as having either an array of vortices with collective excitations at different length scales or an agitated state composed mainly of Bogoliubov phonons.
description: 18 pages, 17 figures, Special issue QGFS2014 of the JLTP
Sonnenfleckenzeichnung Nr. 271.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.12.2012, 09:00, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2012

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Tractable Pathfinding for the Stochastic On-Time Arrival Problem
Creators: name: Niknami, Mehrdad
name: Samaranayake, Samitha
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: G.2.2
subject: 68W99

description: We present a new and more efficient technique for computing the route that maximizes the probability of on-time arrival in stochastic networks, also known as the path-based stochastic on-time arrival (SOTA) problem. Our primary contribution is a pathfinding algorithm that uses the solution to the policy-based SOTA problem---which is of pseudo-polynomial-time complexity in the time budget of the journey---as a search heuristic for the optimal path. In particular, we show that this heuristic can be exceptionally efficient in practice, effectively making it possible to solve the path-based SOTA problem as quickly as the policy-based SOTA problem. Our secondary contribution is the extension of policy-based preprocessing to path-based preprocessing for the SOTA problem. In the process, we also introduce Arc-Potentials, a more efficient generalization of Stochastic Arc-Flags that can be used for both policy- and path-based SOTA. After developing the pathfinding and preprocessing algorithms, we evaluate their performance on two different real-world networks. To the best of our knowledge, these techniques provide the most efficient computation strategy for the path-based SOTA problem for general probability distributions, both with and without preprocessing.
description: Submission accepted by the International Symposium on Experimental Algorithms 2016 and published by Springer in the Lecture Notes in Computer Science series on June 1, 2016. Includes typographical corrections and modifications to pre-processing made after the initial submission to SODA'15 (July 7, 2014)
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1998
Subjects: Community/Rural/Urban Development

description: Overview: Value-Added Manufacturing---An Important Link to the Larger U.S. Economy; Recent Trends in Value-Added Industries: Agricultural- and Wood Products-Based Manufacturing Industries Growing at a Modest Pace, Most Value-Added Manufacturing Increased Its Attachment to Rural Areas During 1989-94; Workers and Wages: Value-Added Workers Earn Less, Have Less Education Than Other Rural Manufacturing Workers; Local Linkages: Value-Added Manufacturing Has Strong Local Linkages; Capital Investment: Investment Patterns Indicate Modest Expansion by Value-Added Industries, Most Value-Added Firms Have Access to Needed Capital; Exports: Trade Agreements May Open New Markets for Value-Added Exports, Farm- and Forest-Related Value-Added Exports Boost the U.S. Economy; Appendixes: 1-Data Sources, 2-Definitions, 3-Latest Trends in Nonfarm Jobs and Earnings, 4-Two Methods of Measuring Farm-Linked Employment, 5-Economic Activity Triggered By Agricultural Trade
Sonnenfleckenzeichnung Nr. 235.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.11.2012, 11:30, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2012

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Genomic discovery and functional validation of MRP1 as a novel fetal hemoglobin modulator and potential therapeutic target in sickle cell disease
Creators: name: Hara, Yannis
name: Kawabata, Emily
name: Lemgart, Viktor
name: Bronson, Paola
name: Hicks, Alexandra
name: Peters, Robert
name: Krishnamoorthy, Sriram
name: Ribeil, Jean-Antoine
name: Schmunk, Lisa
name: Eglinton, Jennifer
name: Watkins, Nicholas
name: Roberts, David
name: Di Angelantonio, Emanuele
name: Danesh, John
name: Astle, William
name: Paul, Dirk
name: Lessard, Samuel
name: Butterworth, Adam
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023

description: Sickle cell disease (SCD) remains a major health burden with limited treatment options. Despite promising gene-editing clinical trials, there is an unmet need for cost-effective therapies. As induction of fetal hemoglobin (HbF) is an established therapeutic strategy for SCD, we conducted a genome-wide association study of circulating HbF levels in ~11,000 participants to identify further HbF modulators. We identified associations in 11 genomic regions, including eight novel loci such as ABCC1 (encoding multidrug resistance-associated protein 1, MRP1). Using gene-editing and pharmacological approaches, we showed that inhibition of MRP1 increases HbF, intracellular glutathione levels, and reduces sickling in erythroid cells from SCD patients. Overall, our findings identify several novel genetically-validated potential therapeutic targets for SCD, including promising proof-of-principle results from small molecule inhibition of MRP1.
Towards a Supersymmetric Description of the Fermi Galactic Center Excess
Creators: name: Cahill-Rowley, Matthew
name: Gainer, Jamie
name: Hewett, JoAnne
name: Rizzo, Tom
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We attempt to build a model that describes the {\it Fermi} galactic gamma-ray excess (FGCE) within a UV-complete Supersymmetric framework; we find this to be highly non-trivial. At the very least a successful Supersymmetric explanation must have several important ingredients in order to fit the data and satisfy other theoretical and experimental constraints. Under the assumption that a {\it single} annihilation mediator is responsible for both the observed relic density as well as the FGCE, we show that the requirements are not easily satisfied in many TeV-scale SUSY models, but can be met with some model building effort in the general NMSSM with $\sim 10$ parameters beyond the MSSM. We find that the data selects a particular region of the parameter space with a mostly singlino lightest Supersymmetric particle and a relatively light CP-odd Higgs boson that acts as the mediator for dark matter annihilation. We study the predictions for various observables within this parameter space, and find that searches for this light CP-odd state at the LHC, as well as searches for the direct detection of dark matter, are likely to be quite challenging. It is possible that a signature could be observed in the flavor sector; however, indirect detection remains the best probe of this scenario.
description: 43 pages, 16 figures
Effective string theory and the long-range relativistic corrections to the quark-antiquark potential
Creators: name: Brambilla, Nora
name: Groher, Michael
name: Martinez, Hector E.
name: Vairo, Antonio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The complete expression of the heavy quark-antiquark potential up to order $1/m^2$ is known from QCD in terms of Wilson loop expectation values. We use that expression and a mapping, assumed to be valid at large distances, between Wilson loop expectation values and correlators evaluated in the effective string theory, to compute the potential. We obtain previously unknown results for the spin and momentum-independent parts of the potential. These are linearly rising with the distance and may be interpreted as relativistic corrections to the string tension. We confirm known results for the other parts of the potential. Finally, we compute the discrete spectrum of a heavy quark-antiquark pair whose interaction is just given by the obtained potential.
description: 22 pages, 7 figures, v2: Improved analysis of subleading corrections in the long-distance mapping. References added. Journal version
Integrals of motion in the Many-Body localized phase
Creators: name: Ros, V.
name: Mueller, M.
name: Scardicchio, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We construct a complete set of quasi-local integrals of motion for the many-body localized phase of interacting fermions in a disordered potential. The integrals of motion can be chosen to have binary spectrum $\{0,1\}$, thus constituting exact quasiparticle occupation number operators for the Fermi insulator. We map the problem onto a non-Hermitian hopping problem on a lattice in operator space. We show how the integrals of motion can be built, under certain approximations, as a convergent series in the interaction strength. An estimate of its radius of convergence is given, which also provides an estimate for the many-body localization-delocalization transition. Finally, we discuss how the properties of the operator expansion for the integrals of motion imply the presence or absence of a finite temperature transition.
description: 65 pages, 12 figures. Corrected typos, added references
Webinars sobre Buenas Prácticas en los Procesos Editoriales de Revistas Científicas para LILACS (2019) - Sesión III - Política Editorial
Creators: name: BIREME/OPS/OMS
name: Rode, Sigmar de Mello
name: Sales, Denise Peres
Publisher: name: Zenodo
Year: 2019
Subjects: Buenas prácticas
Ciencia aberta
LILACS
Editores LILACS
Revistas LILACS
Buenas Prácticas Editoriales

description: (03|09) POLÍTICA EDITORIAL - Buenas Prácticas Proceso Editorial LILACS 2019 • Sesión 03 | 23 de mayo de 2019 • Tema: "Política Editorial" • Ponente: Prof. Dr. Sigmar de Mello Rode • Presentación: https://bit.ly/2M6eyiM
title: Lesbische Sappho, Sappho aus Lesbos
Creators: name: Untner, Laura
Year: 2022

description: Die griechische Dichterin Sappho, die im Laufe der Jahrhunderte intensiv rezipiert wird und zu der es diverse biographische Theorien sowie Legenden gibt, erscheint in literarischen Rezeptionszeugnissen immer wieder in homoerotischen Kontexten und selbst als homoerotisch Begehrende. Im Anschluss an einen Überblick zur vor allem deutschsprachigen literarischen Sappho-Rezeption mit Fokus auf Assoziationen der Dichterin mit weiblicher Homosexualität sowie zu (Homo-)Sexualitätsdiskursen insbesondere im 19. Jahrhundert wird mit Hilfe der Interdiskursanalyse als Literaturanalyse nach Jürgen Link gezeigt, wie die literarische Rezeption Sapphos im deutschsprachigen Raum des 19. Jahrhunderts mit zeitgenössischen (Homo-)Sexualitätsdiskursen in Verbindung steht. Als Beispiele dienen Amalie von Imhoffs Versepos Die Schwestern von Lesbos (1800/1801), Eduard Mörikes Gedicht „Erinna an Sappho“ (1863) und Theodor Kocks Kommentar zum sowie Übersetzung des Fr. 31 Voigt in Alkäos und Sappho (1862). Erkennbar werden ambivalent-uneindeutige sowie zumal negativ konnotierte bzw. hegemonial lesbare homoerotische Assoziationen mit Sappho vor allem subtextuell und in Form von Andeutungen durch das Netz der Sappho-Rezeption und entsprechende interdiskursive Elemente in einer Zeit der Tabuisierung, Kriminalisierung sowie Pathologisierung weiblicher Homosexualität.
description: The Greek poet Sappho, about whom there are several biographical theories as well as legends, has been intensively received over the centuries. In literary texts, she repeatedly appears in homoerotic contexts and as a woman who sexually desires other women. Following an overview especially of the German literary reception of Sappho with a focus on associations of the poet with female homosexuality as well as a survey of discourses dealing with (homo-)sexuality predominantly in the 19th century, this thesis uses interdiscourse analysis as a literary analysis as described by Jürgen Link to show how Sappho’s literary reception in the German-speaking world of the 19th century is related to contemporary discourses dealing with (homo-)sexuality. Examples include Amalie von Imhoff’s verse epic Die Schwestern von Lesbos (1800/1801), Eduard Mörike’s poem „Erinna an Sappho“ (1863), and Theodor Kock’s commentary on and translation of fr. 31 Voigt in Alkäos und Sappho (1862). It is shown how, in a time when female (homo-)sexuality is tabooed, criminalized and pathologized, ambivalent, ambiguous and at times rather negative, hegemonic connotations in associations of Sappho with female homosexuality emerge mainly in the subtext and in the form of innuendos through the web spun by the reception of Sappho and certain interdiscursive elements.
Protective and Therapeutic Capacity of Human Single-Chain Fv-Fc Fusion Proteins against West Nile Virus
Creators: name: Lambeth, C.
name: Noonan, K.
name: Ledizet, M.
name: Fikrig, E.
name: Koski, R. A.
name: Kar, K.
name: Diamond, M. S.
name: Murakami, A.
name: Foellmer, H.
name: Sui, J.
name: Gould, L. H.
name: Wang, T.
name: Oliphant, T.
name: Marasco, W. A.
name: de Silva, A. M.
name: Anderson, J. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infection. In this study, we identified a panel of 11 unique human single-chain variable region antibody fragments (scFvs) that bind the envelope protein of West Nile virus. Selected scFvs were converted to Fc fusion proteins (scFv-Fcs) and were tested in mice for their ability to prevent lethal West Nile virus infection. Five of these scFv-Fcs, 11, 15, 71, 85, and 95, protected 100% of mice from death when given prior to infection with virus. Two of them, 11 and 15, protected 80% of mice when given at days 1 and 4 after infection. In addition, four of the scFv-Fcs cross-neutralized dengue virus, serotype 2. Binding assays using yeast surface display demonstrated that all of our scFvs bind to sites within domains I and II of West Nile virus envelope protein. These recombinant human scFvs are potential candidates for immunoprophylaxis and therapy of flavivirus infections.
The Latency-Associated Nuclear Antigen of Rhesus Monkey Rhadinovirus Inhibits Viral Replication through Repression of Orf50/Rta Transcriptional Activation
Creators: name: DeWire, S. M.
name: Damania, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Rhesus monkey rhadinovirus (RRV) is a gamma-2-herpesvirus that is closely related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. We have previously reported that the transcript for RRV latency-associated nuclear antigen (R-LANA) is expressed during lytic replication in rhesus fibroblasts. In this article, we report the development of a latent culture system for RRV and show that mRNA specific for R-LANA is expressed during latency as well. We have characterized the R-LANA protein and demonstrate that it exhibits a nuclear speckled localization and possesses the ability to homodimerize. When expressed in rhesus fibroblasts, R-LANA can inhibit RRV lytic replication in vitro. We have investigated the mechanism behind this inhibition and find that, while R-LANA itself has very little effect on lytic promoters, it can dramatically decrease the transactivation function of RRV Orf50 (Rta), which is the major viral transcription factor. We further show that the mechanism for this repression involves the recruitment of histone deacetylase complexes (HDACs), because R-LANA's ability to repress Orf50 transactivation is completely reversed by the addition of the HDAC inhibitor trichostatin A (TSA). We also report that TSA alone can significantly reactivate RRV from latently infected cells. We propose that the repressive effects of R-LANA on RRV Orf50 transactivation serve to downregulate the transcription of early genes at late times during the lytic cycle and also help to maintain viral latency by preventing viral reactivation.
Trained Baseline System for Language-based Audio Retrieval (Task 6B) in DCASE 2023 Challenge
Creators: name: Xie, Huang
Publisher: name: Zenodo
Year: 2023

description: Here are the checkpoints for the trained baseline system and audio encoder for language-based audio retrieval (task 6b) in DCASE 2023 challenge. For more details about the baseline system, please see https://github.com/xieh97/dcase2023-audio-retrieval. For more info about the challenge, please see https://dcase.community/challenge2023/task-language-based-audio-retrieval.
title: Vergleich der ethischen Theorien von John Stuart Mill und Immanuel Kant in Form und Inhalt
Creators: name: Ziugzda, Liudvikas
Year: 2022

description: Das Ziel dieser Masterarbeit ist das Prüfen der These, ob die Unterschiede von ethischen in den formellen Gegebenheiten liegen oder es dafür doch einen alternativen Erklärungsgrund gibt. Dazu wird der Utilitarismus von John Stuart Mill und die deontologische Ethik von Immanuel Kant verglichen, damit dies anhand eines spezifischen Beispiel konkretisiert wird. Zuerst wird aber ein formales Kriterium ausgehoben, welches wie eine Schablone dienen wird, um zu sehen, ob sich die Theorien wenigstens formal unterscheiden. Es werden die von Campbell Brown entwickelten Argumente, welche Theorien prüfen ob eine Theorie konsequenzialisierbar ist, benutzt, um so zu einem konkreten Vergleichsrahmen zu gelangen. Danach werden die beiden ethischen Theorien genauer untersucht, denn erst danach kann man an ihnen das Kriterium anwenden. Die Argumente und Gedankengänge werden nacheinander durchgegangen, um zu sehen, wie und warum die Theorien als Vertreter des Utilitarismus und der Deontologie gelten könne. Auch werden mehrere Gegenargumente beantwortet, wie die Aussage, dass Mill nicht einmal ein richtiger Utilitarist sei, damit es nicht erscheint, dass die Untersuchung sich mit einer trivialen Frage beschäftigt. Es werden Texte wie “"The Subjection of Woman”" und “"On Liberty" ” besprochen, um ein um Mills Gedankengänge genauer zu beleuchten. Auch Kants Theorie wird einer genauen Untersuchung unterzogen, wobei sogar Derek Parfits kontroverse These, dass Kants Ethik auf einen Regelutilitarismus reduzierbar ist, ernst genommen wird. Durch dieses Untersuchen wird es dann klar, ob und wie sie das formelle Kriterium verfehlen und ob sie sogar sich einander mehr ähneln als gedacht. Falls dies das Ergebis ist, führt es zu der weiteren Frage: wo dann der echte Unterschied zwischen den ethischen Theorien liegt. Dies führt dann zu der Vermutung, dass dieser vielleicht doch inhaltlich ist oder wenigstens formal anders ist als oft angenommen. Wenigstens macht es eine genauere Untersuchung von Hauptbegriffen der Beiden Philosophen, wie zum Beispiel dem Begriff der Freiheit nötig, um zu sehen, ob es dies nicht ermöglicht doch noch Unterschiede findet, welche zuerst nicht so offensichtlich gewesen sind. Dies wird darauffolgend 62 zeigen, ob vielleicht Kant und Mill, wenigstens implizit den Wert von manchen Dingen als sich radikal unterscheidend sehen, was dann auch zu dem Kernpunkt ihrer Theorien führt und sie deswegen als so verschieden erscheinen lässt. Natürlich wird, falls es zu einem anderen Resultat kommen wird, es auch zu dem führen wird, dass die nötigen Schlussfolgerungen gezogen werden, welche die Wichtigkeit solcher formellen Untersuchungen wieder betonen. Durch das Prüfen dieser Zwei Theorien, können dann weitreichende Folgen auf dem Prozess selber gezogen werden.
Exit Probability in Generalised Kinetic Ising Model
Creators: name: Roy, Parna
name: Sen, Parongama
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this paper we study generalised Ising Glauber models with inflow of informa- tion in one dimension and derive expressions for the exit probability using well established analytical methods. The analytical expressions agree very well with the results obtained from numerical simulation only when the interaction is restricted to the nearest neighbor. But as the range of interaction is increased the analytical results deviate from simulation results systematically. The reasons for the deviation as well as some related open questions are discussed.
description: 14 pages, 5 figures, accepted in J Stat Phys
Host Cell DNA Repair Pathways in Adeno-Associated Viral Genome Processing
Creators: name: Choi, V. W.
name: Samulski, R. J.
name: McCarty, D. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Recentstudies have shown that wild-type and recombinant adeno-associated virus (AAV and rAAV) genomes persist in human tissue predominantly as double-stranded (ds) circular episomes derived from input linear single-stranded virion DNA. Using self-complementary recombinant AAV (scAAV) vectors, we generated intermediates that directly transition to ds circular episomes. The scAAV genome ends are palindromic hairpin-structured terminal repeats, resembling a double-stranded break repair intermediate. Utilizing this substrate, we found cellular DNA recombination and repair factors to be essential for generating circular episomal products. To identify the specific cellular proteins involved, the scAAV circularization-dependent vector was used as a reporter in 19 mammalian DNA repair-deficient cell lines. The results show that RecQ helicase family members (BLM and WRN), Mre11 and NBS1 of the Mre11-Rad50-Nbs1 (MRN) complex, and ATM are required for efficient scAAV genome circularization. We further demonstrated that the scAAV genome requires ATM and DNA-PKCS, but not NBS1, to efficiently convert to a circular form in nondividing cells in vivo using transgenic mice. These studies identify specific pathways involved for further elucidating viral and cellular mechanisms of DNA maintenance important to the viral life cycle and vector utilizations.
CLASH-VLT: Insights on the mass substructures in the Frontier Fields Cluster MACS J0416.1-2403 through accurate strong lens modeling
Creators: name: Grillo, C.
name: Suyu, S. H.
name: Rosati, P.
name: Mercurio, A.
name: Balestra, I.
name: Munari, E.
name: Nonino, M.
name: Caminha, G. B.
name: Lombardi, M.
name: De Lucia, G.
name: Borgani, S.
name: Gobat, R.
name: Biviano, A.
name: Girardi, M.
name: Umetsu, K.
name: Coe, D.
name: Koekemoer, A. M.
name: Postman, M.
name: Zitrin, A.
name: Halkola, A.
name: Broadhurst, T.
name: Sartoris, B.
name: Presotto, V.
name: Annunziatella, M.
name: Maier, C.
name: Fritz, A.
name: Vanzella, E.
name: Frye, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a detailed mass reconstruction and a novel study on the substructure properties in the core of the CLASH and Frontier Fields galaxy cluster MACS J0416.1-2403. We show and employ our extensive spectroscopic data set taken with the VIMOS instrument as part of our CLASH-VLT program, to confirm spectroscopically 10 strong lensing systems and to select a sample of 175 plausible cluster members to a limiting stellar mass of log(M_*/M_Sun) ~ 8.6. We reproduce the measured positions of 30 multiple images with a remarkable median offset of only 0.3" by means of a comprehensive strong lensing model comprised of 2 cluster dark-matter halos, represented by cored elliptical pseudo-isothermal mass distributions, and the cluster member components. The latter have total mass-to-light ratios increasing with the galaxy HST/WFC3 near-IR (F160W) luminosities. The measurement of the total enclosed mass within the Einstein radius is accurate to ~5%, including systematic uncertainties. We emphasize that the use of multiple-image systems with spectroscopic redshifts and knowledge of cluster membership based on extensive spectroscopic information is key to constructing robust high-resolution mass maps. We also produce magnification maps over the central area that is covered with HST observations. We investigate the galaxy contribution, both in terms of total and stellar mass, to the total mass budget of the cluster. When compared with the outcomes of cosmological $N$-body simulations, our results point to a lack of massive subhalos in the inner regions of simulated clusters with total masses similar to that of MACS J0416.1-2403. Our findings of the location and shape of the cluster dark-matter halo density profiles and on the cluster substructures provide intriguing tests of the assumed collisionless, cold nature of dark matter and of the role played by baryons in the process of structure formation.
description: 26 pages, 22 figures, 7 tables; accepted for publication in the Astrophysical Journal. A high-resolution version is available at https://sites.google.com/site/vltclashpublic/publications/Grillo_etal_2014.pdf
The Current Status of Unregistered Foreign Workers in the Agricultural Sector and Tasks for Improvement
Creators: name: Eom, Jinyoung
name: Eom, Jinyoung
Publisher: name: Unknown
Year: 2021
Subjects: subject: Labor and Human Capital
subject: Unregistered foreign workers in agriculture
subject: Employment scale
subject: Employment path

description: In agricultural fields, unregistered foreign workers who illegally reside in Korea with illegal work status takes a larger portion than registered foreign workers. This paper conducts quantitative and qualitative surveys and analyses on the scale of unregistered foreign workers in the agricultural sector and how they are employed. It presents the results and their implications on how to improve related policies and systems. Then, it suggests measures to improve the problem of unregistered foreign workers. First, it is necessary to establish a statistical basis for the agricultural labor force. Second, it is essential to identify the causes for the employment of unregistered foreign workers and improve the system accordingly. Third, there is a need to prepare a plan to move the organized and systemized supply channels of unregistered foreign workers to the institutional sphere.
Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus Serotypes
Creators: name: Grieger, J. C.
name: Asokan, A.
name: Govindasamy, L.
name: Wu, Z.
name: Samulski, R. J.
name: Agbandje-McKenna, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Despite the high degree of sequence homology between adeno-associated virus (AAV) serotype 1 and 6 capsids (99.2%), these viruses have different liver transduction profiles when tested as vectors. Examination of the six amino acid residues that differ between AAV1 and AAV6 revealed that a lysine-to-glutamate change (K531E) suppresses the heparin binding ability of AAV6. In addition, the same mutation in AAV6 reduces transgene expression to levels similar to those achieved with AAV1 in HepG2 cells in vitro and in mouse liver following portal vein administration. In corollary, the converse E531K mutation in AAV1 imparts heparin binding ability and increases transduction efficiency. Extraction of vector genomes from liver tissue suggests that the lysine 531 residue assists in preferential transduction of parenchymal cells by AAV6 vectors in comparison with AAV1. Lysine 531 is unique to AAV6 among other known AAV serotypes and is located in a basic cluster near the spikes that surround the icosahedral threefold axes of the AAV capsid. Similar to studies with autonomous parvoviruses, this study describes the first example of single amino acid changes that can explain differential phenotypes such as viral titer, receptor binding, and tissue tropism exhibited by closely related AAV serotypes. In particular, a single lysine residue appears to provide the critical minimum charged surface required for interacting with heparin through electrostatic interaction and simultaneously plays an unrelated yet critical role in the liver tropism of AAV6 vectors.
An Immunogenic and Protective Alphavirus Replicon Particle-Based Dengue Vaccine Overcomes Maternal Antibody Interference in Weanling Mice
Creators: name: de Silva, A.
name: Johnston, R. E.
name: Williams, B. M.
name: White, L. J.
name: Whitmore, A. C.
name: Parsons, M. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A candidate pediatric dengue virus (DENV) vaccine based on nonpropagating Venezuelan equine encephalitis virus replicon particles (VRP) was tested for immunogenicity and protective efficacy in weanling mice in the presence and absence of potentially interfering maternal antibodies. A gene cassette encoding envelope proteins prM and E from mouse-adapted DENV type 2 (DENV2) strain NGC was cloned into a VEE replicon vector and packaged into VRP, which programmed proper in vitro expression and processing of DENV2 envelope proteins upon infection of Vero cells. Primary immunization of 3-week-old weanling BALB/c mice in the footpad with DENV2 VRP resulted in high levels of DENV-specific serum immunoglobulin G antibodies and significant titers of neutralizing antibodies in all vaccinates. A booster immunization 12 weeks after the prime immunization resulted in increased neutralizing antibodies that were sustained for at least 30 weeks. Immunization at a range of doses of DENV2 VRP protected mice from an otherwise-lethal intracranial DENV2 challenge. To model vaccination in the presence of maternal antibodies, weanling pups born to DENV2-immune or DENV2-naïve dams were immunized with either DENV2 VRP or live DENV2 given peripherally. The DENV2 VRP vaccine induced neutralizing-antibody responses in young mice regardless of the maternal immune status. In contrast, live-DENV2 vaccination performed poorly in the presence of preexisting anti-DENV2 antibodies. This study demonstrates the feasibility of a VRP vaccine approach as an early-life DENV vaccine in populations with high levels of circulating DENV antibodies and suggests the utility of VRP-based vaccines in other instances where maternal antibodies make early vaccination problematic.
Ribosomal Protein S6 Interacts with the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
Creators: name: Chen, W.
name: Dittmer, D. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The latency-associated nuclear antigen (LANA) is central to the maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) and to the survival of KSHV-carrying tumor cells. In an effort to identify interaction partners of LANA, we purified authentic high-molecular-weight complexes of LANA by conventional chromatography followed by immunoprecipitation from the BC-3 cell line. This is the first analysis of LANA-interacting partners that is not based on forced ectopic expression of LANA. Subsequent tandem mass spectrometry (MS/MS) analysis identified many of the known LANA-interacting proteins. We confirmed LANA's interactions with histones. Three classes of proteins survived our stringent four-step purification procedure (size, heparin, anion, and immunoaffinity chromatography): two heat shock proteins (Hsp70 and Hsp96 precursor), signal recognition particle 72 (SRP72), and 10 different ribosomal proteins. These proteins are likely involved in structural interactions within LANA high-molecular-weight complexes. Here, we show that ribosomal protein S6 (RPS6) interacts with LANA. This interaction is mediated by the N-terminal domain of LANA and does not require DNA or RNA. Depletion of RPS6 from primary effusion lymphoma (PEL) cells dramatically decreases the half-life of full-length LANA. The fact that RPS6 has a well-established nuclear function beyond its role in ribosome assembly suggests that RPS6 (and by extension other ribosomal proteins) contributes to the extraordinary stability of LANA.
Forecasting Bulb Weight of Median-Late Variety Onion Using Growth Indicators and Meteorological Factors
Creators: name: Kim, Jisu
name: Kim, Jisu
Publisher: name: Unknown
Year: 2021
Subjects: subject: Crop Production/Industries
subject: Onion
subject: Growth indicators
subject: Meteorological factors

description: This study develops a forecasting model for bulb weight of median-late variety onion to alleviate supply-demand imbalance. The actual measurement data in 2020/2021 are from the Korea Rural Economic Institute (KREI). A multilevel model is applied to reflect the hierarchical data characteristics consisting of growth indicators in individual units and meteorological factors in parcel units. The results are as the following: The harvest timing should be considered when constructing the forecasting model since the weights vary depending on that. The growth indicators, especially the number of leaves, at the early bulb enlargement period and the number of optimum temperature days during the bulb enlargement period show the positive effects on the bulb weight at the harvest. It is possible to forecast the growth indicators at the early bulb enlargement period using those at the early leaf elongation period. When applying the estimation results for 2020 and 2021 data, the growth indicators at the early bulb enlargement period can be explained as much as about 90% based on those at the early leaf elongation period.
Construction of Maximal Hypersurfaces with Boundary Conditions
Creators: name: Lambert, Ben
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We construct maximal hypersurfaces with a Neumann boundary condition in Minkowski space via mean curvature flow. In doing this we give general conditions for long time existence of the flow with boundary conditions with assumptions on the curvature of a the Lorentz boundary manifold.
title: Diagnostik in DaZ-Alphabetisierungskursen
Creators: name: Kusto, Natalia
Year: 2022

description: Die vorliegende Masterarbeit beschäftigt sich mit den Erfahrungen der Lehrkräfte in den Alphabetisierungskursen im Rahmen von KASA-Projekt. Sie setzte sich mit den theoretischen Konzepten der Alphabetisierung in einer Zweitsprache und den Herausforderungen in solchen Alphabetisierungskursen auseinander. Um diese Herausforderungen zu erforschen, werden sechs ExpertInneninterviews durchgeführt, die im Anschluss mithilfe der Qualitativen Inhaltsanalyse nach Mayring ausgewertet werden. Auf diese Weise werden die Erfahrungen der Lehrkräfte in den (Online-)Alphabetisierungskursen festzuhalten.
Additional file 1 of Quality of antibiotic prescribing for pediatric community-acquired Pneumonia in outpatient care
Creators: name: Saatchi, Ariana
name: Haverkate, Manon R.
name: Reid, Jennifer N.
name: Shariff, Salimah Z.
name: Povitz, Marcus
name: Patrick, David M.
name: Silverman, Michael
name: Morris, Andrew M.
name: McCormack, James
name: Marra, Fawziah
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
ASSOCIATION BETWEEN HIV KNOWLEDGE AND RISK BEHAVIOR IN PERSONS WHO INJECT DRUGS IN THAI NGUYEN, VIETNAM
Creators: name: Davis, Wendy
name: Lim, Travis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In Vietnam, HIV infection is concentrated in key populations including persons who inject drugs (PWID). The majority of PWID can name specific transmission routes of HIV, yet risk behaviors remain high. We conducted a cross-sectional survey of 1355 PWID in Thai Nguyen Province, Vietnam, to and compare their HIV knowledge with their self-reported risk behavior. Broader knowledge of HIV transmission, measured by a higher composite HIV knowledge score, was associated with a 19.5% lower adjusted odds of giving a used needle to another (p=0.011), and 20.4% lower adjusted odds of using a needle that another had used (p=0.001). A higher knowledge score was associated with 13.1% higher adjusted odds of consistent condom use (p=0.083). These results suggest a broader knowledge may reflect characteristics about how individuals obtain knowledge or the way that knowledge is delivered to them, and may be associated with their ability to engage in risk reduction behavior.
Complications, revision fusions, readmissions, and utilization over a 1-year period after bone morphogenetic protein use during primary cervical spine fusions
Creators: name: Goode, Adam P.
name: Schectman, Robin M.
name: Carey, Timothy S.
name: Richardson, William J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Nationwide estimates examining Bone Morphogenetic Protein (BMP) use with cervical spine fusions have been limited to perioperative outcomes.
Canine specific ELISA for coagulation factor VII
Creators: name: Kristensen, Annemarie T.
name: Wiinberg, Bo
name: Kjalke, Marianne
name: Kjelgaard-Hansen, Mads
name: Hansen, Jens Jacob
name: Nichols, Timothy C.
name: Jensen, Asger L.
name: Tranholm, Mikael
name: Knudsen, Tom
name: Clausen, Jes T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been available to date. In this study, a canine specific ELISA for measurement of FVII:Ag in plasma was developed and validated. The FVII:Ag ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVII:C, the FVII:Ag ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency.
Generic construction of scale-invariantly coarse grained memory
Creators: name: Shankar, Karthik H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Biological sciences
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Encoding temporal information from the recent past as spatially distributed activations is essential in order for the entire recent past to be simultaneously accessible. Any biological or synthetic agent that relies on the past to predict/plan the future, would be endowed with such a spatially distributed temporal memory. Simplistically, we would expect that resource limitations would demand the memory system to store only the most useful information for future prediction. For natural signals in real world which show scale free temporal fluctuations, the predictive information encoded in memory is maximal if the past information is scale invariantly coarse grained. Here we examine the general mechanism to construct a scale invariantly coarse grained memory system. Remarkably, the generic construction is equivalent to encoding the linear combinations of Laplace transform of the past information and their approximated inverses. This reveals a fundamental construction constraint on memory networks that attempt to maximize predictive information storage relevant to the natural world.