title: ÐÐ·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð², ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ñ Ð±ÐµÐ»ÐºÐ¸ Z-Ð´Ð¸ÑÐºÐ°, Ð¿ÑÐ¸ Ð³Ð¸Ð¿ÐµÑÑÑÐ¾ÑÐ¸Ð¸ Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð°
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ½ÑÐ·ÐµÐ²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð³Ð¸Ð¿ÐµÑÑÑÐ¾ÑÐ¸Ñ Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð°
Ð¼ÐµÑ Ð°Ð½Ð¾ÑÑÐ°Ð½ÑÐ´ÑÐºÑÐ¸Ñ
Z-Ð´Ð¸ÑÐº
Z-disc proteins
hypertrophy of myocardium
mechanotransduction

description: Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð², ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ñ Ð±ÐµÐ»ÐºÐ¸ Z-Ð´Ð¸ÑÐºÐ°, Ð¿ÑÐ¸ Ð³Ð¸Ð¿ÐµÑÑÑÐ¾ÑÐ¸Ð¸ Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð°, Ð²ÑÐ·Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð³ÐµÐ¼Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ°Ð¼Ð¸ Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÐºÐ¾Ð°ÑÐºÑÐ°ÑÐ¸Ð¸ Ð°Ð¾ÑÑÑ (ÐÐ) Ð¸ Ð½ÐµÐ³ÐµÐ¼Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ°Ð¼Ð¸ Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÐµÐ½Ð¾Ð²Ð°ÑÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð³Ð¸Ð¿ÐµÑÑÐµÐ½Ð·Ð¸Ð¸ (Ð Ð). Ð Ð°Ð±Ð¾ÑÐ° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð½Ð° ÐºÑÑÑÐ°Ñ Ð»Ð¸Ð½Ð¸Ð¸ ÐÐ¸ÑÑÐ°Ñ Ð² Ð²Ð¾Ð·ÑÐ°ÑÑÐµ 8 Ð½ÐµÐ´ÐµÐ»Ñ. ÐÐ¸Ð²Ð¾ÑÐ½ÑÐµ Ð±ÑÐ»Ð¸ ÑÐ°Ð·Ð´ÐµÐ»ÐµÐ½Ñ Ð½Ð° Ð³ÑÑÐ¿Ð¿Ñ Ð² ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ð¸ ÑÐ¾ Ð²ÑÐµÐ¼ÐµÐ½ÐµÐ¼ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸. Ð£ÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² Ð² Ð»ÐµÐ²Ð¾Ð¼ (ÐÐ) Ð¸ Ð¿ÑÐ°Ð²Ð¾Ð¼ (ÐÐ) Ð¶ÐµÐ»ÑÐ´Ð¾ÑÐºÐ°Ñ Ð¸Ð·Ð¼ÐµÑÑÐ»Ð¸ Ð¿ÑÐ¸ Ð¿Ð¾Ð¼Ð¾ÑÐ¸ ÐÐ¦Ð  Ð² ÑÐµÐ°Ð»ÑÐ½Ð¾Ð¼ Ð²ÑÐµÐ¼ÐµÐ½Ð¸. ÐÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ actn2, fhl2 Ð² ÐÐ Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÐÐ Ð² Ð³ÑÑÐ¿Ð¿Ðµ Â«2 Ð½ÐµÐ´ÐµÐ»Ð¸Â». ÐÑÐ»Ð¾ ÑÐ°ÐºÐ¶Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ cmya5, actn2, nebl Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð Ð: Ð²Ð¾Ð·ÑÐ°ÑÑÐ°Ð½Ð¸Ðµ Ð½Ð° ÑÐ°Ð½Ð½Ð¸Ñ ÑÑÐ¾ÐºÐ°Ñ (1, 2 Ð½ÐµÐ´ÐµÐ»Ð¸) Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸ÐµÐ¼ Ð´Ð¾ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¾Ð²Ð½Ñ Ð² ÐÐ, Ð¸ Ð¿Ð¾ÑÑÐµÐ¿ÐµÐ½Ð½Ð¾Ðµ Ð²Ð¾Ð·ÑÐ°ÑÑÐ°Ð½Ð¸Ðµ Ðº Ð¿Ð¾Ð·Ð´Ð½Ð¸Ð¼ ÑÑÐ¾ÐºÐ°Ð¼ (8, 10 Ð½ÐµÐ´ÐµÐ»Ñ) Ð² ÐÐ. ÐÑÐ¾Ð¸ÑÑÐ¾Ð´Ð¸Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ des Ð½Ð° ÑÑÐ¾ÐºÐ°Ñ 1 Ð¸ 2 Ð½ÐµÐ´ÐµÐ»Ð¸ Ð² ÐÐ Ð¸ Ð² ÐÐ. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð½Ð° Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ ÑÐ¸Ð¿Ð° Ð³Ð¸Ð¿ÐµÑÑÑÐ¾ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¸ Ð²ÑÐµÐ¼ÐµÐ½Ð¸ ÐµÐµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð° Ð¿ÑÐ¾ÑÐ¸Ð»Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð², ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ñ ÑÑÑÑÐºÑÑÑÐ½ÑÐµ Ð¸ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÐµ Ð±ÐµÐ»ÐºÐ¸ Z-Ð´Ð¸ÑÐºÐ°, Ð¸ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´Ð°ÑÑ ÑÐ¾Ð»Ñ Ð±ÐµÐ»ÐºÐ¾Ð² Z-Ð´Ð¸ÑÐºÐ° Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð³Ð¸Ð¿ÐµÑÑÑÐ¾ÑÐ¸Ð¸ Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¸ Ð¿ÑÐ°Ð²Ð¾Ð³Ð¾ Ð¶ÐµÐ»ÑÐ´Ð¾ÑÐºÐ¾Ð².
description: The goal of present work was to investigate expression of genes encoding Z-disc proteins in cardiac hypertrophy, caused by hemodynamic or neurohumoral factors. 8 week old male Wistar rats underwent ascending aortic constriction to perform coarctation of the aorta (CoA) or renal artery clipping to implement renovascular hypertension model (RH). Animals were divided into groups regarding to time of model duration. Gene expression in right (RV) and left (LV) ventricles was analyzed by real-time PCR. We established downregulation of actn2 and fhl2 in CoA in Â«2 weekÂ» group in LV. We also demonstrated altered expression of cmya5, actn2, nebl in RH model: increase at the early stage (1, 2 weeks), followed by decrease to basal level in LV and gradual increase to the later stage (8, 10 weeks) in RV. Des was upregulated only at the early stage (1, 2 weeks) both in RV and LV. These results point out that type of hypertrophic stimuli and stage of hypertrophy progression could affect patterns of expression of genes encoding structural or signaling Z-disk proteins. Thus, confirming involvement of Z-disc proteins in the development of cardiac hypertrophy both, in LV and RV.