The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D for the potential Symptom Reducer, Prevention and Treatment for Coronavirus Disease 2019 (COVID-19)
Creators: name: Orzechowski, Michelle
name: Ahmed, Amr
name: Elkazzaz, Mahmoud
name: Al.Katten, Abdullah
Publisher: name: figshare
Year: 2021
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Milan, Italy had the first specimen detect SARS-CoV-2 from the specimen source: Oropharyngeal Swab, collected on 2019-12-05 but was reported on 2020-11-30. Wuhan, China however, had the first specimen identify SARS-CoV-2 from the specimen source: Bronchoalveolar lavage, collected on 2019-12-24 and reported first to the world on 2020-01-11. As of today, there have been over 3 Million reported cases of SARS-CoV-2 globally in Humans, Animals and in the Environment. Currently 9 different Variants are emerging from SARS-CoV-2 including: Alpha, Beta, Gamma, Delta, Eta, Iota, Kappa, Lambda, and Mu that have been reported as of 01-Sep-2021. There have been over 1,200 reported cases of SARS-CoV-2 in the following specimens for 14 different Animals including: Dog, Cat, Hamster, Mouse, Otter, Monkey, Gorilla, Anteater, Mink, Lion, Tiger, Leopard, Snow Leopard, and Bat. There have been over 1,200 reported cases of SARS-CoV-2 in the Environment from the following samples: Sewer and Wastewater. [0]<br>There is currently a global outbreak of respiratory disease caused by a novel coronavirus that has been named “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The disease caused by the virus has been named “Coronavirus Disease 2019” (COVID-19). On January 31, 2020, the Department of Health and Human Services (HHS) issued a declaration of a public health emergency related to COVID-19 and mobilized the Operating Divisions of HHS. In addition, on March 13, 2020, there was a Presidential declaration of a national emergency in response to COVID-19. Therefore, FDA is taking urgent measures to protect consumers from certain products that, without approval or authorization by FDA, claim to mitigate, prevent, treat, diagnose, or cure COVID-19 in people. [1]<br>At the Pharmacy Compounding Advisory Committee on September 12, 2018 the FDA was proposing that quercetin dihydrate NOT be included on the 503A Bulks List. The Vote Result proposing if quercetin dihydrate should be placed on the list was: YES: 0 NO: 11 ABSTAIN: 0. The Meeting Committee Discussion for the Vote was that: The committee unanimously agreed that quercetin dihydrate NOT be included on the 503A Bulks List. Many committee members expressed concerns with the lack of reasonable data supporting the use of quercetin dehydrate in its proposed indications, the amount of known drug interactions with this product, and the number of products that are currently available for these conditions that are already proven to be safe and efficacious. Several committee members also noted that the product is widely available over-the-counter as an oral dietary supplement, and in the future, more substantial data would be needed to consider an IV formulation. Please note that one committee member was not present for the vote. Please see the transcript for details of the committee discussion. [2]<br>Hypotheses:<br>The Combination of Quercetin and Bromelain with Zinc, EGCG, Retinoic Acid, Vitamin C and Vitamin D when taken together may Inhibit the Viral Replication of Anti-Cytokine Storm and an Antiviral against RNA Viruses like Coronavirus Disease 2019 (COVID-19) by using the formulations including Zinc; Zinc Ionophores (Quercetin) ; Bromelain, EGCG, Retinoic Acid, Vitamin C and Vitamin D the Zinc Ionophores possibly enhance transport of Zinc into the Cells to effect Intra-Cellular Zinc levels and potentially impair intracellular replication of Coronavirus Disease 2019 (COVID-19) The supplements listed below describe how COVID-19 is potentially treated using the following over the counter supplements: • Zinc regulates Adaptive Immune Cell Functions with High levels of Intracellular pH as RNA-dependent and RNA polymerase decreases the replication of RNA viruses like COVID-19 • Quercetin has chelate Zinc Ions and act as a Zinc Ionophore.• Bromelain activates Natural Killer Cells and production of Granulocyte Macrophage Colony Stimulating Factor, Interleukin-2 and Interleukin-6 decreases the activation of T-helper Cells. • EGCG can suppress ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2, which mediate cell entry of the virus.• Retinoic Acid has a characteristic of antiviral , Immunity induction , ACE2 upregulation or downregulation and anti-clotting [16] • Vitamin C has Enzymatic Co-Factor for Hormone Production, Collagen Synthesis and Immune Potentiation.• Vitamin D regulates the Inflammatory Cytokine Response. [5]<br>