cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3: of Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma
Creators: name: Cheng-Lung Hsu
name: Kar-Wai Lui
name: Lang-Ming Chi
name: Yung-Chia Kuo
name: Yin-Kai Chao
name: Yeh, Chun-Nan
name: Lee, Li-Yu
name: Yenlin Huang
name: Tung-Liang Lin
name: Mei-Yuan Huang
name: Lai, Yi-Ru
name: Yeh, Yuan-Ming
name: Hsien-Chi Fan
name: Lin, An-Chi
name: Yen-Jung Lu
name: Chia-Hsun Hsieh
name: Chang, Kai-Ping
name: Ngan-Ming Tsang
name: Hung-Ming Wang
name: Chang, Alex
name: Yu-Sun Chang
name: Hsin-Pai Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Figure S1. Single nucleotide variations (SNV) of five metastatic NPC-PDX tumors. Somatic mutations (including non-synonymous missense and splice site mutations) of the five NPC-PDX tumors identified from sequencing data are listed (upper panel). Each bar represents the number of base substitutions. For the 282 SNVs, the percentage of each base substitution is indicated (lower panel). (PDF 402 kb)
Solid oxide electrochemical reactors and processes for carbon dioxide and water splitting
Creators: name: Kleiminger, Lisa
Publisher: name: Imperial College London
Year: 2015

description: The increasing contributions of renewable energy sources into the electricity grid necessitates large-scale energy storage to balance supply and demand due to their inherent intermittency. Storing electrical energy in chemical bonds by electrolysis of CO2 and / or H2O is one option. The aims of this project were to develop and characterise (micro)-tubular solid oxide electrolysers for the reduction of CO2 and/or steam at temperatures of 700–800 °C. Micro-tubular hollow fibre reactors were fabricated by phase inversion. Ni(O) – yttria stabilised zirconia (YSZ) cermet electrodes (electrolysis cathode) and YSZ electrolyte (15-50 μm) were simultaneously co-extruded and sintered, followed by the application of a lanthanum strontium doped manganite (LSM) – YSZ|LSM electrode (electrolysis anode) onto the outer surface, which was subsequently sintered. At 800 °C, current densities of up to -1.0 A cm-2 were achieved at ca. 1.8 V for CO2 electrolysis with a silver wire and silver conductive paste cathodic lumen current collector. Replacing the silver wire with nickel and removing any paste additives resulted in a 50 % increase in current density. Electrode polarization for steam and co-electrolysis (H2O/CO2 co-feed) was 62-382 % lower compared to CO2 electrolysis, with the extent depending on the current collector design; the silver paste had a greater detrimental effect on the electrode performance of the SOE operating with CO2. Evidence supporting dual-step co-electrolysis with electro-generation of hydrogen preceding the heterogeneous chemical reaction of H2 with CO2 included electrochemical performance, adsorption modelling, diffusion considerations, and response to silver paste. However, isotopic studies to differentiate between (electro)chemical processes using labelled C18O2 and H216O were inconclusive due to oxygen-18 exchange occurring between C18O2 and H216O, within the alumina feed tube, despite the absence of a Ni-YSZ cathode acting as a catalyst. To further characterize the intrinsic CO2 reduction mechanism, the surface exchange kinetics of C18O2 on YSZ and oxide diffusion coefficients, without electrochemical polarization, were determined using secondary ion mass spectrometry. These results facilitated the analyses of SOE experiments using oxygen-18 tracers that compared the effect of applied current on oxide ion transport rates within the hollow fibre reactors. Techno-economical evaluation of intra-day energy storage using the micro-tubular reactors cyclically in electrolyser and fuel cell operational mode resulted in an electricity storage cost of £0.016 per kWh, considering capital and operating costs (assuming £0.1 per kWh electricity costs), which is lower than current pumped hydroelectric storage (£0.05 per kWh).
Additional file 1: of Root inoculation with Azotobacter chroococcum 76A enhances tomato plants adaptation to salt stress under low N conditions
Creators: name: Oosten, Michael Van
name: Stasio, Emilio Di
name: Cirillo, Valerio
name: Silletti, Silvia
name: Ventorino, Valeria
name: Pepe, Olimpia
name: Raimondi, Giampaolo
name: Maggio, Albino
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology

description: Figure S1. Gene Expression of ion transporters. (A) NHX1, (B) NHX2, (C) HKT1;1, relative Expression (RQ) quantified by qRT-PCR in samples of uninoculated (control) and inoculated (76A) plants treated with: 0 mM, 50 mM, and 100 mM NaCl. Single asterisks denote significant differences according to Student (P
Mesoscale modelling of steel processing
Creators: name: Arif, Tansel
Publisher: name: Imperial College London
Year: 2015

description: Numerical methods are utilised to reproduce the evolution of a system observed in natural phenomena. Within the area of materials science there is an increase of interest in modelling techniques that can accurately predict the microstructure of a material subject to various processing conditions. Recently, there is a requirement of techniques that have the ability to be applied to systems involving microstructural change in the presence of fluid flow. This presents a challenge since the forces governing these processes involve those predominately influenced by thermodynamics as well as those influenced by hydrodynamics. The phase-field method, a popular technique used in this area, has been shown to have the ability to cope with phase transformation dynamics such as solidification and solid-state phase transformations. However, its predictive capabilities mainly apply to a flow free environment where flow effects are minimal compared to other effects. Other techniques such as smoothed particle hydrodynamics exist that are more than capable of describing the mechanisms of flow demonstrating superiority in many complex flow problems. The thermodynamic quantities related to the evolution of a system to which this method is applied must then be consistent in order to be translated between models. This thesis develops the tools necessary to deal with phase growth and microstructural change within the presence of flow. This is done by developing phase-field models that can efficiently deal with displacive transformations in steels as well as diffusive, and SPH models with the ability to be coupled with thermodynamics. The phase-field models are developed to be applied to structure growth observed at relatively low temperatures within steels, namely martensite and bainite growth. The SPH method is analysed in order to assess and provide solutions for consistency when considered for coupling with models mainly dependent on thermodynamics.
The Breuil-Mézard conjecture when l is not equal to p
Creators: name: Shotton, Jack
Publisher: name: Imperial College London
Year: 2015

description: Let l and p be primes, let F/Q_p be a finite extension with absolute Galois group G_F, let F be a finite field of characteristic l, and let p̄ : G_F→ GL_n(F) be a continuous representation. Let R^□(p̄) be the universal framed deformation ring for p̄. If l = p, then the Breuil-Mézard conjecture relates the mod l reduction of certain cycles in R^□(p̄) to the mod l reduction of certain representations of GL_n(O_F). We give an analogue of the Breuil-Mézard conjecture when l ≠ p, and prove it whenever l > 2 using automorphy lifting theorems. We also give a local proof when n = 2 and l> 2 by explicit calculation, and also when l is "quasi-banal'' for F and p̄ is tamely ramified.
Functional analysis of the condensin complex during the metaphase to anaphase transition of budding yeast
Creators: name: Leonard, Joanne Caroline
Publisher: name: Imperial College London
Year: 2015

description: The precise division of DNA into two daughter nuclei is a critical event in every cell cycle. The pairing of sister chromatids in order to allow accurate segregation, is achieved by two primary mechanisms – the SMC complex cohesin binds as replication ends and holds sisters together with protein-mediated links; and the process of replication intertwines sister chromatids in a way that results in DNA-DNA mediated links called catenations. At the point of segregation, it is crucial that cohesin is destroyed and all catenations are resolved. Topoisomerase 2 (Top2) is the primary actor in S. cerevisiae able to resolve DNA inter- twines. This enzyme appears to maintain an equilibrium level of catenations between S phase and mitosis and it has been shown to be capable of both introducing and removing catenations by its strand passage mechanism. At the metaphase to anaphase transition, a shift to positive supercoiling may help to direct the action of topoisomerase enzymes towards full decatenation at the crucial moment of DNA segregation. Further, it has been shown that condensin, another SMC complex, has a pivotal role in this supercoiling transition. Here, work is presented to link this change in supercoiling to physical tension across sister chromatids aligned on the metaphase plate. The regulation of this transition requires Cdc5 kinase, Ipl1 kinase and acts independently of the Spindle Assembly Checkpoint. Furthermore, the supercoiling transition is linked to a global enrichment of Smc2 across the entire length of chromosomes as the spindles form and anaphase progresses. This enrichment is matched by Top2 binding and this Top2 enrichment depends directly on the action of Smc2. It is hypothesised that this recruitment of Top2 is dependent on catenations being revealed by the supercoiling action of Smc2. If Top2 is not active, then Smc2 continues to bind globally to DNA and further increase the level of positive supercoiling, suggesting that the complex is able to sense the presence of remaining catenations. Finally, a secondary last minute catenane resolution pathway may have been identified that occurs after the supercoiling transition and is regulated by the Anaphase Promoting Complex.
Simultaneous interpretation of $K$ and $B$ anomalies in terms of chiral-flavorful vectors
Creators: name: Matsuzaki, Shinya
name: Nishiwaki, Kenji
name: Yamamoto, Kei
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We address the presently reported significant flavor anomalies in the Kaon and $B$ meson systems such as the CP violating Kaon decay ($ε'/ε$) and lepton-flavor universality violation in $B$ meson decays ($R_{K^{(*)}},{R_{D^{(*)}}}$), by proposing flavorful and chiral vector bosons as the new physics constitution at around TeV scale. The chiral-flavorful vectors (CFVs) are introduced as a 63-plet of the global $SU(8)$ symmetry, identified as the one-family symmetry for left-handed quarks and leptons in the standard model (SM) forming the 8-dimensional vector. Thus the CFVs include massive gluons, vector leptoquarks, and $W',Z'$-type bosons, which are allowed to have flavorful couplings with left-handed quarks and leptons, and flavor-universal couplings to right-handed ones, where the latter arises from mixing with the SM gauge bosons. The flavor texture is assumed to possess a "minimal" structure to be consistent with the current flavor measurements on the $K$ and $B$ systems. Among the presently reported significant flavor anomalies in the Kaon and $B$ meson systems ($ε'/ε$, $R_{K^{(*)}}, {R_{D^{(*)}}}$), the first two $ε'/ε$ and $R_{K^{(*)}}$ anomalies can simultaneously be interpreted by the presence of CFVs, the ${R_{D^{(*)}}}$ anomaly is predicted not to survive, due to the approximate $SU(8)$ flavor symmetry. Remarkably, we find that as long as both of the $ε'/ε$ and $R_{K^{(*)}}$ anomalies persist beyond the SM, the CFVs predict the enhanced $K^+ \to π^+ ν\barν$ and $K_L \to π^0 ν\barν$ decay rates compared to the SM values, which will readily be explored by the NA62 and KOTO experiments, and they will also be explored in new resonance searches at the Large Hadron Collider.
description: 52 pages, 14 figures, 1 table, version published in JHEP
The anthropometric, environmental and genetic determinants of right ventricular structure and function
Creators: name: Dawes, Timothy
Publisher: name: Imperial College London
Year: 2015

description: BACKGROUND Measures of right ventricular (RV) structure and function have significant prognostic value. The right ventricle is currently assessed by global measures, or point surrogates, which are insensitive to regional and directional changes. We aim to create a high-resolution three-dimensional RV model to improve understanding of its structural and functional determinants. These may be particularly of interest in pulmonary hypertension (PH), a condition in which RV function and outcome are strongly linked. PURPOSE To investigate the feasibility and additional benefit of applying three-dimensional phenotyping and contemporary statistical and genetic approaches to large patient populations. METHODS Healthy subjects and incident PH patients were prospectively recruited. Using a semi-automated atlas-based segmentation algorithm, 3D models characterising RV wall position and displacement were developed, validated and compared with anthropometric, physiological and genetic influences. Statistical techniques were adapted from other high-dimensional approaches to deal with the problems of multiple testing, contiguity, sparsity and computational burden. RESULTS 1527 healthy subjects successfully completed high-resolution 3D CMR and automated segmentation. Of these, 927 subjects underwent next-generation sequencing of the sarcomeric gene titin and 947 subjects completed genotyping of common variants for genome-wide association study. 405 incident PH patients were recruited, of whom 256 completed phenotyping. 3D modelling demonstrated significant reductions in sample size compared to two-dimensional approaches. 3D analysis demonstrated that RV basal-freewall function reflects global functional changes most accurately and that a similar region in PH patients provides stronger survival prediction than all anthropometric, haemodynamic and functional markers. Vascular stiffness, titin truncating variants and common variants may also contribute to changes in RV structure and function. CONCLUSIONS High-resolution phenotyping coupled with computational analysis methods can improve insights into the determinants of RV structure and function in both healthy subjects and PH patients. Large, population-based approaches offer physiological insights relevant to clinical care in selected patient groups.
Bayesian nonparametric approaches to modelling dependencies in systems biology
Creators: name: Zurauskiene, Justina
Publisher: name: Imperial College London
Year: 2014

description: All living organisms exhibit complex behaviour, and this is a result of the underlying regulatory mechanisms that occur at cellular and molecular levels. For this reason such reactions are of central importance in the field of systems biology. Throughout this thesis we are concerned with mathematical models that allow us to better under- stand and represent the biological phenomena behind experimental data, and equally to make predictions about key regulatory processes happening in the cells. Specifically, this work explores and demonstrates how modern Bayesian nonparametric techniques, namely Gaussian process regression and Dirichlet process mixture models, can be applied in order to model complex systems biology data. Here we have developed a new technique based on Gaussian process regression approaches to model metabolic regulatory processes at the cellular level. Our technique allows us to model noisy metabolite time course data and predicts dynamical metabolic flux behaviour in the associated pathways; we demonstrate that by learning the dependencies between several metabolites we can strengthen our predictions in sparsely sampled regions. We furthermore discuss when Gaussian processes can accurately reconstruct the underlying functions and when they are subject to the Nyquist limit. Next we proceed to modelling biological processes that occur at the molecular level. Here we are interested in studying large and diverse functional genomics datasets. A variety of computational techniques allow us to analyse such data and model biological processes underlying them; an important class of these methods are techniques that permit the detection of heterogeneity in experimentally observed data. Here we employ Dirichlet processes to estimate the number of clusters within such genomic datasets and further propose a new method to tackle the data fusion problem. Our technique primarily relies on the outcomes from nonparametric Bayesian clustering approaches and is based on graph theory concepts, but in parallel we also discuss and show how this graph-theoretical approach can be extended to integrate results from non-Bayesian type clustering algorithms. We show that by integrating several data types we can successfully identify e.g. sets of genes that are regulated by similar transcription factors.
Tables S1 - S3 from Structure validation of oxidized poly (2-hydroxyethyl acrylate) with multiple aldehyde groups and its application for collagen modification
Creators: name: Liu, Baohua
name: Wang, Jian
name: Ji, Lili
name: Bai, Ting
name: Zhang, Yin
name: Liu, Dayu
Publisher: name: The Royal Society
Year: 2021

description: Table S1: Retain times and peak areas of HEA, OHEA and AA; Table S2: Relative molecular weights and aldehyde contents of OP with different degrees of oxidation; Table S3: The charge of aldehyde carbon in the optimized structures of OP and glutaraldehyde
title: 01_0882
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1: of Avoid reinventing the wheel: implementation of the Ottawa Clinic Assessment Tool (OCAT) in Internal Medicine
Creators: name: Halman, Samantha
name: Rekman, Janelle
name: Wood, Timothy
name: Baird, Andrew
name: Gofton, Wade
name: Dudek, Nancy
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Hematology

description: The Ottawa Clinic Assessment Tool (OCAT). (DOCX 17 kb)
A long hard-X-ray look at the dual active galactic nuclei of M51 with NuSTAR
Creators: name: Brightman, M.
name: Baloković, M.
name: Koss, M.
name: Alexander, D. M.
name: Annuar, A.
name: Earnshaw, H.
name: Gandhi, P.
name: Harrison, F. A.
name: Hornschemeier, A. E.
name: Lehmer, B.
name: Powell, M. C.
name: Ptak, A.
name: Rangelov, B.
name: Roberts, T. P.
name: Stern, D.
name: Walton, D. J.
name: Zezas, A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present a broadband X-ray spectral analysis of the M51 system, including the dual active galactic nuclei (AGN) and several off-nuclear point sources. Using a deep observation by NuSTAR, new high-resolution coverage of M51b by Chandra, and the latest X-ray torus models, we measure the intrinsic X-ray luminosities of the AGN in these galaxies. The AGN of M51a is found to be Compton thick, and both AGN have very low accretion rates ($λ_{\rm Edd} <10^{-4}$). The latter is surprising considering that the galaxies of M51 are in the process of merging, which is generally predicted to enhance nuclear activity. We find that the covering factor of the obscuring material in M51a is $0.26 \pm 0.03$, consistent with the local AGN obscured fraction at $L_{\rm X}\sim 10^{40}$ erg s$^{-1}$. The substantial obscuring column does not support theories that the torus, presumed responsible for the obscuration, disappears at these low accretion luminosities. However, the obscuration may have resulted from the gas infall driven by the merger rather than the accretion process. We report on several extra-nuclear sources with $L_{\rm X}>10^{39}$ erg s$^{-1}$ and find that a spectral turnover is present below 10 keV in most such sources, in line with recent results on ultraluminous X-ray sources.
description: Accepted for publication in ApJ
Optical structure and polarization of the western hot spot of Pictor A
Creators: name: Thomson, R. C.
name: Crane, P.
name: Mackay, C. D.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: HST images of the western hot spot of the nearby FRII radio galaxy Pictor A resolve the hot spot into an amorphous region of highly polarized wisps. The high polarization (>~ 50%) indicates that the optical emission is synchrotron radiation and that the magnetic field structure has been well resolved. The magnetic field is oriented nearly perpendicular to the jet axis and apparently very uniform. We interpret these observations in terms of a compressed magnetic field at the working surface where the jet impinges on the intergalactic medium some 100 kpc from the nucleus of the host galaxy. Keywords: Polarization --- radiation mechanisms: nonthermal --- galaxies: active --- galaxies: individual: Pictor A --- galaxies: jets.
description: uuencoded compressed postscript. The preprint is also available at http://www.ast.cam.ac.uk/preprint/PrePrint.html
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Cart. 168 (11 H 66), f. 0117r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0117r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0117r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Role of natural killer cells in cord blood transplantation
Creators: name: Sekine, Takuya
Publisher: name: Imperial College London
Year: 2015

description: Cord blood transplantation (CBT) for high-risk hematologic cancers is limited by the low numbers of immune cells in a single CB unit, leading to diminished graft-versus-leukemia effect. Although natural killer (NK) cells can mediate potent graft-versus-leukemia effect, and are the first reconstituting lymphocytes after transplantation, the receptor-ligand interactions mediating their cytotoxicity are not well understood. I first studied killer-cell immunoglobulin-like receptor (KIR) and HLA genotypes, NK phenotype and function for 110 CBT recipients to identify specific patterns of KIR-HLA interaction that might predict for CBT effectiveness. I found that the donor genotype of HLA-C1-KIR2DL2/3 combined with KIR2DS2/3 to be an important predictor of disease control after CBT in patients with an HLA-C1/C1 or HLA-C1/C2 background. These findings suggest means to improve the clinical efficacy of NK cells in HLA-defined patient subgroups, especially those with HLA-C2 homozygosity. I then extended my studies to investigate the role of NK cells in the control of CMV reactivation, as cord blood grafts are known to be more susceptible to latent virus infection from lack of transfer of adaptive subsets unlike other graft sources. I found that CB grafts expressing a NKG2C deletion allele possessed higher risk of CMV reactivation post CBT, with the risk significantly reduced with the presence of the wild type allele. Results collectively suggested that the susceptibility of CBT recipients to CMV reactivation is determined by the NKG2C content of the infused CB units. Based on the current understanding of NK licensing/education, the most critical developmental process required for functional competence, I attempted to identify markers that distinguish between ‘licensed/educated’ and ‘unlicensed/hyporesponsive’ NK cells. I discovered differential adhesive properties between the two functionally distinct subsets, and also report the possible contribution of the adaptor protein CrkL in NK licensing/education.
Details of method and additional results from Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models
Creators: name: Alrabghi, Ghadah
name: Liu, Yizhou
name: Hu, Wei
name: Hancox, Jules C.
name: Zhang, Henggui
Publisher: name: The Royal Society
Year: 2023

description: Previous studies have linked dysfunctional Ito arising from mutations to KCND3-encoded Kv4.3 and KCND2-encoded Kv4.2 to atrial fibrillation (AF). Using computational models, this study aimed to investigate the mechanisms underlying pro-arrhythmic effects of the gain-of-function Kv4.3 (T361S, A545P) and Kv4.2 (S447R) mutations. Wild-type and mutant Ito formulations were developed from and validated against experimental data and incorporated into the Colman et al. model of human atrial cells. Single-cell models were incorporated into one- (1D) and two-dimensional (2D) models of atrial tissue, and a three-dimensional (3D) realistic model of the human atria. The three gain-of-function mutations had similar, albeit quantitatively different, effects: shortening of the action potential duration; lowering the plateau membrane potential, abbreviating the effective refractory period (ERP) and the wavelength (WL) of atrial excitation at the tissue level. Restitution curves for the WL, ERP and the conduction velocity were leftward shifted, facilitating the conduction of atrial excitation waves at high excitation rates. The mutations also increased lifespan and stationarity of re-entry in both 2D and 3D simulations, which further highlighted a mutation-induced increase in spatial dispersion of repolarization. Collectively, these changes account for pro-arrhythmic effects of these Kv4.3 and Kv4.2 mutations in facilitating AF.This article is part of the theme issue ‘The heartbeat: its molecular basis and physiological mechanisms’.
Discovery of Radio-loud Broad Absorption Line Quasars Using Ultraviolet Excess and Deep Radio Selection
Creators: name: Brotherton, M. S.
name: van Breugel, Wil
name: Smith, R. J.
name: Boyle, B. J.
name: Shanks, T.
name: Croom, S. M.
name: Miller, Lance
name: Becker, Robert H.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report the discovery of five broad-absorption-line (BAL) QSOs in a complete sample of 111 ultraviolet excess (UVX) QSO candidates also detected in the NRAO VLA Sky Survey. All five BAL QSOs, which include two high-ionization BAL QSOs and three low-ionization BAL QSOs, are formally radio-loud. Of QSOs with z > 0.4, 3+/-2% show low-ionization BALs, and of QSOs with z > 1.5, all radio-loud, 9+/-5% show BALs; these frequencies are consistent with those of optical surveys. While the first reported radio-loud BAL QSO, FIRST J155633.8+351758, is likely to be heavily dust reddened and thus less radio-loud than indicated by its observed radio-to-optical luminosity, these QSOs are UVX selected and probably free of significant dust along the line of sight. We point out unusual features in two of the BAL QSOs and discuss the significance finding these heretofore rare objects.
description: 9 pages, 1 figure, accepted by ApJ Letters. Table 1 has been revised with a 0.24 mag zero point correction to the BAL QSO U-Bj colors
Immersive Virtual Reality Serious Games for Evacuation Training and Research: A Systematic Literature Review
Creators: name: Feng, Zhenan
name: González, Vicente A.
name: Amor, Robert
name: Lovreglio, Ruggiero
name: Cabrera, Guillermo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computers and Society (cs.CY)
subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: An appropriate and safe behavior for exiting a facility is key to reducing injuries and increasing survival when facing an emergency evacuation in a building. Knowledge on the best evacuation practice is commonly delivered by traditional training approaches such as videos, posters, or evacuation drills, but they may become ineffective in terms of knowledge acquisition and retention. Serious games (SGs) are an innovative approach devoted to training and educating people in a gaming environment. Recently, increasing attention has been paid to immersive virtual reality (IVR)-based SGs for evacuation knowledge delivery and behavior assessment because they are highly engaging and promote greater cognitive learning. This paper aims to understand the development and implementation of IVR SGs in the context of building evacuation training and research, applied to various indoor emergencies such as fire and earthquake. Thus, a conceptual framework for effective design and implementation through the systematic literature review method was developed. As a result, this framework integrates critical aspects and provides connections between them, including pedagogical and behavioral impacts, gaming environment development, and outcome and participation experience measures.
Additional file 1: of Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma
Creators: name: Cheng-Lung Hsu
name: Kar-Wai Lui
name: Lang-Ming Chi
name: Yung-Chia Kuo
name: Yin-Kai Chao
name: Yeh, Chun-Nan
name: Lee, Li-Yu
name: Yenlin Huang
name: Tung-Liang Lin
name: Mei-Yuan Huang
name: Lai, Yi-Ru
name: Yeh, Yuan-Ming
name: Hsien-Chi Fan
name: Lin, An-Chi
name: Yen-Jung Lu
name: Chia-Hsun Hsieh
name: Chang, Kai-Ping
name: Ngan-Ming Tsang
name: Hung-Ming Wang
name: Chang, Alex
name: Yu-Sun Chang
name: Hsin-Pai Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Supplementary Materials and Methods. (DOCX 16 kb)
On correlators of Reggeon fields and operators of Wilson lines in high energy QCD
Creators: name: Bondarenko, S.
name: Pozdnyakov, S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this note we derive Dyson-Schwinger hierarchy of the equations for the correlators of reggeized gluon fields in the framework of Lipatov's high energy QCD effective action formalism, \cite{LipatovEff,Our1,Our2,Our3,Our4}. The explicit perturbative expressions for the correlators till correlator of four Reggeon fields inclusively are obtained and different perturbative schemes for the solutions of the equation for the two-field correlator are discussed. A correspondence between the correlators of reggeized gluon fields and Wilson line operators of longitudinal gluon field is established with the help of \cite{Our4} paper results. The connection between the JIMWLK-Balitsky formalism and Lipatov's effective action approach and applications of the obtained results are also discussed.
description: 20 pages, 10 figures
A Statistic for identifying cosmic string wakes and other sheet-like structure
Creators: name: Robinson, James
name: Albrecht, Andreas
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We describe an implementation of the structure functions of Babul \& Starkman, in order to quantify the ``sheet-like'' nature of a distribution of matter. We test this statistic on a toy model describing cosmic string wakes, and show that it does a better job than other statistics which have been proposed for distinguishing non-Gaussianity in the form of sheets. We conclude that the most favoured cosmic string model is unlikely to produce a significant increase in the sheet-like nature of the matter distribution beyond that which occurs in Gaussian models (with the same power spectrum) due to the formation of Zeldovich pancakes. Although the statistic was developed in the context of cosmic string wake formation, we expect it to be useful for comparing the observed galaxy distribution with a wide range of theoretical models with different power spectra.
description: Latex file, 18 pages, 13 figures. One additional figure available by anoymous ftp to ftp://euclid.tp.ph.ic.ac.uk/Papers/94-5_36.fig . Results and discussion updated to take into account improvements in our computer code. Latex and postscript versions also available at http://euclid.tp.ph.ic.ac.uk/Papers/index.html
Kekulé valence bond order in an extended Hubbard model on the honeycomb lattice, with possible applications to twisted bilayer graphene
Creators: name: Xu, Xiao Yan
name: Law, K. T.
name: Lee, Patrick A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Using large-scale quantum Monte Carlo simulations, we exactly solve a model of Fermions hopping on the honeycomb lattice with cluster charge interactions, which has been proposed as an effective model with possible application to twisted bilayer graphene near half-filling. We find an interaction driven semimetal to insulator transition to an insulating phase consisting of a valence bond solid with Kekulé pattern. Finite size scaling reveals that the phase transition of the semimetal to Kekulé valence bond solid phase is continuous and belongs to chiral XY universality class.
description: 4+1 pages, 4 figures
The Spin of M87 as measured from the Rotation of its Globular Clusters
Creators: name: Kissler-Patig, Markus
name: Gebhardt, Karl
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We revisit the kinematical data for 204 globular clusters in the halo of M87. Beyond 3 r_eff along the major axis of the galaxy light, these globular clusters exhibit substantial rotation (~ 300 +/- 70 km/s) that translates into an equally substantial spin (lambda ~ 0.18). The present appearance of M87 is most likely the product of a single major merger, since this event is best able to account for so sizable a spin. A rotation this large makes improbable any significant accretion of material after this merger, since that would have diluted the rotation signature. We see weak evidence for a difference between the kinematics of the metal-poor and metal-rich population, in the sense that the metal-poor globular clusters appear to dominate the rotation. If, as we suspect, the last major merger event of M87 was mainly dissipationless and did not trigger the formation of a large number of globular clusters, the kinematic difference between the two could reflect their orbital properties in the progenitor galaxies; these differences would be compatible with these progenitors having formed in dissipational mergers. However, to put strong kinematic constraints on the origin of the globular clusters themselves is difficult, given the complex history of the galaxy and its last dominant merger event.
description: 20 pages (AAS two column style, including 1 table and 7 figures) accepted in the AJ (November issue), also available at http://www.ucolick.org/~mkissler/
Assessing airways deposition, physiology and pharmacokinetics of monodisperse aerosols in obstructive lung disease
Creators: name: Kalsi, Harpal
Publisher: name: Imperial College London
Year: 2015

description: Inhaled medication is standard therapy in asthma and COPD. However the amount of drug reaching the lung is influenced by several factors including aerosol particle size and upper airway morphology. While smaller sized aerosol particles may be transported to the small airways there is still a need to examine the systemic risk and efficacy associated with small particle aerosols. On one hand small particles can be transported to the lung periphery (small airways) where they can reduce small airways dysfunction. On the other hand small particles can increase plasma concentrations of the drug worsening systemic side effects. Aerosol particle size determines deposition throughout the whole of the respiratory tract including the upper airway and by altering aerosol delivery characteristics it is possible to avoid deposition in the upper airway. This thesis set out to investigate how to improve drug deposition in the lung by controlling aerosol delivery characteristics mainly particle size and flow rate and investigate how the filtering effects of the upper airway can be overcome. The specific aims of this thesis were: To quantify aerosol deposition in the upper airway both in vitro and in vivo with the hope of using in vitro techniques to predict what happens in vivo. Explore how aerosol particle size effects lung deposition and pulmonary bioavailability through pharmacokinetics. Investigate and evaluate novel tests of small and large airways function and see if these can detect physiological improvement following inhalation of small (1.5 µm) particles and large (6 µm) particles. In vitro tests on upper airway models somewhat predicted what happens in vivo. The increasing effect of both particle size and flow rate was shown to increase upper airway deposition. Tests of respiratory function and inflammation demonstrated greater between test variability than routine tests of lung function and warrant further evaluation. Improvements in small and large airway function were not associated with the deposition of small and large aerosol particles following one off dosing of an inhaled corticosteroid fluticasone propionate and a link between these tests and aerosol particle size warrants further investigation.
Additional file 1 of The Mesorhizobium huakuii transcriptional regulator AbiEi plays a critical role in nodulation and is important for bacterial stress response
Creators: name: Chen, Xiaohong
name: Hu, Aiqi
name: Zou, Qian
name: Luo, Sha
name: Wu, Hetao
name: Yan, Chunlan
name: Liu, Tao
name: He, Donglan
name: Li, Xiaohua
name: Cheng, Guojun
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. Inhibition zones of the H2O2 in disc diffusion test of different strains. Filter paper discs were impregnated with a solution containing 20 (A-D), 100 (E-H) and 250 (I-L) mg L− 1 of H2O2, and placed on the TY media plate on which bacteria had been spread. Plates were incubated at 28 °C for 96 h. A, E, I, M. huakuii 7653R; B, F, J, M. huakuii HKabiEi; C, G, K, M. huakuii HKabiEi(pBBRabiEi); D, H, L, M. huakuii HKabiEi(pBBR1MCS-5).
A Survey for Low-Surface-Brightness Galaxies Around M31. I. The Newly Discovered Dwarf Andromeda V
Creators: name: Armandroff, Taft E.
name: Davies, James E.
name: Jacoby, George H.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present images and a color-magnitude diagram for And V, a new dwarf spheroidal companion to M31 that was found using a digital filtering technique applied to 1550 square degrees of the second Palomar Sky Survey. And V resolves into stars easily in follow-up 4-m V- and I-band images, from which we deduce a distance of 810 +/- 45 kpc using the tip of the red giant branch method. Within the uncertainties, this distance is identical to the Population II distances for M31 and, combined with a projected separation of 112 kpc, provides strong support for a physical association between the two galaxies. There is no emission from And V detected in H alpha, 1.4 GHz radio continuum, or IRAS bandpasses, and there is no young population seen in the color-magnitude diagram that might suggest that And V is an irregular. Thus, the classification as a new dwarf spheroidal member of the Local Group seems secure. With an extinction-corrected central surface brightness of 25.2 V mag per square arcsec, a mean metal abundance of [Fe/H] approximately -1.5, and no evidence for upper AGB stars, And V resembles And I & III.
description: Accepted for publication in The Astronomical Journal, November 1998 issue; 4 embedded PostScript figures, 4 JPEG figures; see http://aloe.tuc.noao.edu/jacoby/dwarfs.html for a complete full-resolution PostScript version
QuantumInformation.jl---a Julia package for numerical computation in quantum information theory
Creators: name: Gawron, Piotr
name: Kurzyk, Dariusz
name: Pawela, Łukasz
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Numerical investigations are an important research tool in quantum information theory. There already exists a wide range of computational tools for quantum information theory implemented in various programming languages. However, there is little effort in implementing this kind of tools in the Julia language. Julia is a modern programming language designed for numerical computation with excellent support for vector and matrix algebra, extended type system that allows for implementation of elegant application interfaces and support for parallel and distributed computing. QuantumInformation.jl is a new quantum information theory library implemented in Julia that provides functions for creating and analyzing quantum states, and for creating quantum operations in various representations. An additional feature of the library is a collection of functions for sampling random quantum states and operations such as unitary operations and generic quantum channels.
description: 32 pages, 8 figures
title: ASD and behavioural interventions: an introduction for school personnel: an external review
Creators: name: O'Keefe, Chelsea
Publisher: name: Memorial University of Newofundland
Year: 2020

description: This study encompasses an external program review of ASD and Behavioural Interventions: An Introduction for School Personnel (ASD & BI), an online course distributed through the New Brunswick Department of Education and Early Childhood Development. The course is designed for educational professionals who seek additional training on autism spectrum disorder and appropriate interventions. This study focuses on the province of New Brunswick only. Sixty participants were included, and data collection occurred from November 2017 until April 2018. The participants completed pre- and post-test survey questionnaires at the start and finish of the course and a brief post-test short answer questionnaire. This information provided the data necessary to address the overarching research questions: How effective is ASD & BI perceived to be by participants? What is perceived as working well and what do participants perceive as not working? And, what is the typical demographic of participants who enroll in the course? The Wilcoxon Signed-Rank test showed that there were significant differences between the pre- and post-test results (p<0.001), indicating a likelihood that completion of the course had resulted in significant changes in participants’ perceived competency of ASD. Five themes emerged through the qualitative short answer responses which were expanded on and utilized to develop four recommendations for future disseminations of ASD & BI. The small sample size and homogeneousness of the participant demographics suggests that the results of this review should not be generalized as the experiences of all professionals who enroll in the course but is a relevant to the immediate context of the current study. Additional reviews should be considered in the future, specifically those that include Newfoundland, Nova Scotia and Prince Edward Island.