cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
E02787: Latin letter from the deacon Paschasius of Rome to the abbot Eugippius of Lucullanum (near Naples), acknowledging receipt of the Life of Severinus (see E02347) and its accompanying letter (E02786), and underlining the significance of putting the deeds of saints into writing.
Creators: name: Mpignot
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Eugippius of Lucullanum, Life of Severinus

Letter of Paschasius to Eugippius

Acknowledging receipt of Eugippius' Life of Severinus ($E02347) and the letter asking him to write a more extensive account (E02786), Paschasius replies that this is not required since Eugippius has done a much better job than he himself would have done in narrating the deeds of Severinus. He emphasises the importance of relating the deeds of saints as examples, recalling the advice of Peter (1 Peter 5:3) and Paul (1 Tim. 4:12; Heb. 11), and the example of Mattathias (1 Macc. 2:49).

Relevant passages:

§§ 2-3: Direxisti commemoratorium, cui nihil possit adicere facundia peritorum, et opus, quod ecclesiae possit universitas recensere, brevi reserasti compendio, dum beati Severini finitimas Pannoniorum provincias incolentis vitam moresque verius explicasti et quae per illum divina virtus est operata miracula diuturnis mansura temporibus tradidisti memoriae posterorum – nesciunt facta piorum praeterire cum saeculo – ut omnes praesentem habeant et secum quodam modo sentiant commorari, quibus eum relatio pervexerit lectionis. Et ideo, quia tu haec quae a me narranda poscebas elocutus es simplicius, explicasti facilius, nihil adiciendum labori vestro studio nostro credimus.’

'You have sent me your memorandum, to which nothing can be added by the eloquence of learned men. You have compressed in a short compass a work worthy to be placed before the whole Church. You have made known truthfully the life and character of blessed Severinus, who lived in the provinces bordering on the Pannonias, and you have handed down to posterity the memory of the miracles which the power of God has worked through him and which will last for all time – the works of the pious cannot perish with their age. You have done this in such a way that all those to whom the reading of your report brings him can see him, as it were, present, and, in some way, experience his company. And, therefore, since you have told with greater simplicity, and explained more gracefully than I could do what you ask me to relate, I believe that nothing can be added to your work by our effort.'

§ 4: Divinis charismatibus inspiratus scis, bonorum mentibus excolendis quantum gesta sanctorum utilitatis impertiant, quantum fervoris attribuant, quantum puritatis infundant.

'Inspired by divine gifts, you know what great stimulus the deeds of the saints can add to the improvement of the minds of good men, what great fervour they give them, what strength of purity they instil.'

Text: Noll 1981, 46-49. Translation: Bieler-Krestan 1965, 101-102 (from which paragraph numbers are taken; lightly adapted).
DFT study on the Ciclopirox anticancer drug interaction with AlN nanostructures: analysed by AIM, UV-Vis and Marcus theory of electron-transfer
Creators: name: Saadh, Mohamed J.
name: Herrera, Tatiana Elizabeth Sánchez
name: Dhiaa, Aya Mohammed
name: Cáceres, Oswaldo Villacrés
name: Fiallos, Linda Mariuxi Flores
name: Oviedo, Byron Stalin Rojas
name: Omran, Alaa A.
name: Hawas, Majli Nema
name: Elawady, Ahmed
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: This study's main focus was on the process by which Ciclopirox adhered to AlN nanostructures, Calculations using the density functional theory were done to reach this goal. The calculations encompassed the assessment of Ciclopirox's adsorption energy, the evaluation of the energy band gap, the analysis of variations in the energy band gap, the examination of charge transfers, and the characterisation of the types of interactions that arise from Ciclopirox's adsorption onto AlN nanostructures. We carried out an investigation using the AIM method to explore deeper into the binding properties between the studied AlN nanostructures and Ciclopirox. Our discoveries provide light on the Ciclopirox/AlN nanosheet interaction's electrostatic characteristics. Moreover, the presence of Ciclopirox led to an augmentation in the electrical conductivity of the AlN nanostructures. This intriguing outcome suggests the potential application of these AlN nanomaterials as chemical sensors, capable of generating an electronic signal upon detection of this chemically modified amino acid. The observed sensitivity sequence indicated that the AlN nanosheet exhibited the highest sensitivity, followed by the AlN nanotube and the AlN nanocluster. In conclusion, our study provides compelling evidence supporting the AlN nanosheet as an excellent choice for the detection of Ciclopirox compared to other AlN nanostructures.
Additional file 1 of Contribution of the World Health Organization/ the special program for research and training in tropical disease (WHO/TDR’s) in institution building: lessons from Ethiopia
Creators: name: Kaba, Mirgissa
name: Solomon, Kalkidan
name: Kitaw, Yayehyirad
name: Berhe, Derbew Fikadu
name: Abdissa, Alemseged
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
The potential energy surface and superatomic properties of the octahedral PtSn5 cluster
Creators: name: Zhang, Manli
name: Liu, Qiman
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified

description: Zintl (group IV elements) clusters with a special number of valence electrons often exhibit extraordinary structures and chemical bonding patterns, and the stability of them is rationalised by the Wade-Mingos rule. However, this rule is still limited for some Zintl clusters. Here, we find that the potential energy surface of PtSn5 has a single deep funnel, which leads down to the octahedron of the global minimum. The AIMD simulations demonstrate that the octahedral PtSn5 still has a good thermal stability at 1000 K. The molecular orbitals and AdNDP analyses reveal that the 20 valence electrons from five Sn atoms of the PtSn5 fill superatomic shells resulting in an electronic configuration of 1S21P61D102S2, and the electronic structure of the Pt atom is d10, well following the magic number of the Jellium model. The result is further confirmed by the density of states and the localised orbital locator. After the CO molecule is adsorbed on the PtSn5, it prefers to be located at the Pt atom. Due to the charge-transfer effect, the C–O bond length and stretching frequency appear to change significantly. Our work opens up the study on the Jellium model for Zintl clusters.
E02788: Fragmentary Greek inscription possibly mentioning a church of *Kosmas and Damianos (brothers, physician martyrs of Syria, S00385). Found at Jerusalem on the Via Dolorosa (Roman province of Palaestina I). Probably 6th-7th c.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: The preserved text:

[- - -]τῶν ἁγίων Α[- - -]
[- - -] τοῦ μακαριω[τάτου- - -]
[- - -]Υ τελευτὴ̣ν [- - -]
[- - - τ]ῶν Βυζαντ[ίων - - -]
[- - -] καὶ θ(εο)ῦ καὶ Σ[ωτῆρος (?) - - -]

'[- - -] of the holy A[- - -] of the most blessed [- - -] completed (or: died) [- - -] the Byzantines [- - -] and God and [Saviour (?) - - -].'

The restoration by Germer-Durand:

[οἶκος] τῶν ἁγίων Ἀ[ναργύ]-
[ρων ἐπὶ] τοῦ μακαριω[τάτου]
[Εὐστοχί]ου τελευτὴν [ἔλαβε]
[σπουδῇ] τῶν Βυζαντ[ίων εἰς]
[δόξαν] Κ(υρίο)υ καὶ θ(εο)ῦ καὶ Σ[ωτῆρος]

'[The house] of the holy [Unmercenaries (Anargyroi)] was completed [under] the most blessed [Eustochios by the zeal] of (the monastery) of the Byzantines [for the glory] of the Lord and God and [Saviour].'

The restoration by Milik:

[οὗτος ὁ εὐαγὴς οἶκος] τῶν ἁγίων Ἀ[ναργύρων Κοσμᾶ καὶ]
[Δαμιανοῦ συσταθεὶς διὰ] τοῦ μακαριω[τάτου ἀρχιεπισκόπου]
[καὶ πατριάρχου Ἰσαακίο]υ τελευτὴν [ἔλαβε σπουδῇ τοῦ δεῖνα]
[καὶ τῆς δεῖνα] τῶν Βυζαντ[ίων μηνὶ - - - ἰνδ(ικτιῶνος) - - -]
[ἔτους τῆς σαρκώσεως Κ(υρίο)υ] καὶ θ(εο)ῦ καὶ Σ[ωτῆρος ἡμῶν Ἰ(ησο)ῦ Χ(ριστο)ῦ - - -]

'[This chaste house] of the holy [Unmercenaries (Anargyroi) Kosmas and Damianos, founded by] the most blessed [archbishop and patriarch Isaakios], was completed [by the care of NN and his wife NN], the Byzantines, [in the month of - - -, indiction - - -, in the year of the incarnation of the Lord], and God, and [our Saviour Christ - - -].'

Text: CIIP 1/2, no. 1010. Translations: L. Di Segni, lightly adapted.
Dr. Tarun Pal Honored with Best Published Author Award 2025 by Glory International University
Creators: name: Dr Tarun Pal, Researcher
Publisher: name: Zenodo
Year: 2025
Subjects: GIU
GloryInternationalUniversity
BestPublishedAuthor2025
DrTarunPal
LiteraryExcellence

description: Dr. Tarun Pal Honored with Best Published Author Award 2025 by Glory International University

March 19, 2025 – San Francisco, USAGlory International University, USA, proudly recognizes Dr. Tarun Pal as the recipient of the prestigious Best Published Author Award 2025 for his outstanding contributions to literature in the fields of Child Education, Critical Thinking, and Self-Help.

Dr. Tarun Pal is a distinguished author whose literary works have had a global impact. With over 20 books published in English and Bangla, his writings have inspired and educated readers across multiple continents. His books are available on 19+ international platforms, reaching audiences in the USA, UK, China, France, Italy, and beyond.

At Glory International University, we believe that knowledge is the foundation of progress. Dr. Pal’s dedication to fostering education and personal development through his books aligns with our mission to promote intellectual growth and lifelong learning. His contributions have profoundly influenced students, educators, and professionals worldwide.

In acknowledging his achievements, Prof. Jack David Noe, President of Glory International University, stated:

"Dr. Tarun Pal’s work exemplifies the power of literature to transform lives. His commitment to writing and publishing impactful books has contributed immensely to education and personal development. We are honored to present him with this well-deserved recognition."

This award celebrates Dr. Tarun Pal’s literary excellence and his unwavering dedication to enriching minds across the globe. We extend our heartfelt congratulations and look forward to his continued contributions to the world of literature.

📌 For more information about Dr. Tarun Pal’s books, search on Google: "Dr. Tarun Pal books"
Additional file 1 of AQbD TLC-densitometric method approach along with green fingerprint and whiteness assessment for quantifying two combined antihypertensive agents and their impurities
Creators: name: Nagieb, Hend M.
name: Abdelwahab, Nada S.
name: Abdelrahman, Maha M.
name: Zaazaa, Hala E.
name: Ghoniem, Nermine S.
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1: Figure S1. Flow chart highlights the most important stages of AQbD step by step. Figure S2. Calibration graphs for captopril and hydrochlorothiazide and their impurities illustrating linear regression equation and correlation coefficient (r). Figure S3. Visualization and comparison of the evaluation results of the four model methods for determination of captopril and hydrochlorothiazide and their impurities according to the 12 principles of WAC, performed using the RGB 12 algorithm. Figure S4. Comparison of the main evaluation outcomes obtained from the RGB 12 analysis where the white dashed line indicates 100% - a full fitness for planned application. The values above 100 indicate additional capabilities exceeding current requirements. Table S1. Analytical target profile elements for TLC-densitometric method for determination of captopril and hydrochlorothiazide and their impurities. Table S2. Regression and validation parameters for the developed TLC – densitometry method for determination of captopril and hydrochlorothiazide in presence of their impurities. Table S3. Eco-scale scores of the developed and the reported method.
Unveiling the mechanism and regioselectivity of the [3 + 2] cycloaddition reaction between N-methylphenylnitrone and 1-sulphonyl-1-trifluoromethylallene. A MEDT study
Creators: name: Messikh, Samia
name: Sobhi, Chafia
name: Malfi, Najran
name: Yahia, Wassila
name: Chouit, Hanifa
name: Kerboua, Adlen
name: Chermette, Henry
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The present study reports within the molecular electron density theory the mechanism and the selectivity of the [3 + 2] cycloaddition (32CA) reaction between an N-methyl-phenylnitrone (nitrone 5) toward the poorest electrophile1-sulphonyl-1-trifluoromethylallene (allene 6) using DFT method at the B3LYP/6-31G(d) theoretical level. Four reactive pathways associated with the ortho and meta regioselective channels and endo and exo stereoselective approaches modes have been explored and characterised. While the formation of the meta/exo cycloadduct as the major isomer proceeds via a stepwise mechanism with the participation of zwitterion intermediate. Whereas, the other three pathways follow a one-step mechanism, the conceptual DFT reactivity indices analysis explains correctly the polar character of this 32CA reaction, and the local Parr functions analysis enables us to explain the meta-regioselectivity observed experimentally. The presence of both trifluromethyl and sulphonyl as electron-withdrawing groups increase markedly the reactivity of the allene and produces the meta selectivity. The inclusion of the solvent effects does not modify the obtained gas-phase selectivities but slightly increases the activation energies as well as the meta-exo stereoselectivity. QTAIM analyse reveal that the presence of significant numbers of conventional and non-conventional interactions at both TSs of the most favourable meta channel is responsible for the complete regioselectivity observed experimentally at this 32CA reaction.
E02789: Latin hymn to *Severinus (hermit and monk of Noricum, S00848) for the feast day of Severinus. On the basis of the episodes told in the Life of Severinus by Eugippius (E02347), it praises Severinus for the miracles he performed, the help he gave to people oppressed by war, and his writing of a monastic rule. Presumably written in Naples, at an uncertain date, possibly late antique.
Creators: name: Mpignot
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Anonymous hymn to Saint Severinus

Summary:

Praises Severinus on the day of his death (hunc diem festum celebremus omnes, quo Severinus penetravit almus), and recounts miracles performed, in particular protection of cities through prayer, apparition of heavenly light, multiplication of oil, healing, the resurrection of Silvinus. It also refers to the rule for monks prepared by Severinus. The hymn directly addresses the city of Naples, the likely intended audience.

Text: Knöll 1886, 71-73. Summary: M. Pignot.
Supplemental Material, 0_-_JSR_SE_-_Executive_Summary - From Customer-, to Actor-, to Stakeholder Engagement: Taking Stock, Conceptualization, and Future Directions
Creators: name: Hollebeek, Linda D.
name: V. Kumar
name: Srivastava, Rajendra K.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental Material, 0_-_JSR_SE_-_Executive_Summary for From Customer-, to Actor-, to Stakeholder Engagement: Taking Stock, Conceptualization, and Future Directions by Linda D. Hollebeek, V. Kumar and Rajendra K. Srivastava in Journal of Service Research
Fairness: from the ethical principle to the practice of Machine Learning development as an ongoing agreement with stakeholders
Creators: name: Curto, Georgina
Publisher: name: University of Notre Dame
Year: 2023

description: This paper clarifies why bias cannot be completely mitigated in Machine Learning (ML) and proposes an end-to-end methodology to translate the ethical principle of justice and fairness into the practice of ML development as an ongoing agreement with stakeholders. The pro-ethical iterative process presented in the paper aims to challenge asymmetric power dynamics in the fairness decision making within ML design and support ML development teams to identify, mitigate and monitor bias at each step of ML systems development. The process also provides guidance on how to explain the always imperfect trade-offs in terms of bias to users.
JALON D3.3 Environmental and socio-economic labels
Creators: name: Cristóbal López, A. B.
name: Sanz-Cuadrado, C.
name: Carrasco Moreno, L. M.
name: Narvarte Fernández, L.
Publisher: name: Zenodo
Year: 2023

description: Document with the definition of two labels as KPIs to quantify socio-economic and environmental impacts.The first Label will be Label 1 "Near Zero Emission Citizen / Municipality / Shop / Business / Company / Association" and will serve to quantify the environmental impact, and the second label will be "Reverting-Depopulation-Process Village / County / Region" and will serve to quantify the socioeconomic impact.
Additional file 3 of Characterization of the pyruvate kinase gene family in soybean and identification of a putative salt responsive gene GmPK21
Creators: name: Liu, Wei
name: Wang, Yubin
name: Zhang, Yanwei
name: Li, Wei
name: Wang, Caijie
name: Xu, Ran
name: Dai, Haiying
name: Zhang, Lifeng
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 3: Figure S3. The subcellular localization of a GmPK21-GFP in tobacco protoplasts.
Exposure to potentially harmful excipients in medications among neonates at a state hospital in Malaysia
Creators: name: Wong, Shien Woan
name: Chew, Soo Piing
name: Aziz, Siti Azdiah Abdul
name: Shah, Noraida Mohamed
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study aimed to determine the incidence, types and predictors of Potentially Harmful Excipients (PHE) exposure among hospitalized neonates. A prospective observational study was conducted from March to April 2022 in neonatal wards at a state hospital in Malaysia. The PHEs of interest were aspartame, benzalkonium chloride, benzyl alcohol, benzoic acid or benzoates, ethanol, parabens, polysorbate 80, propylene glycol, saccharin sodium, sorbitol and sulfites. Product information leaflets (PILs) and summaries of product characteristics (SPCs) were referred to obtain information on active pharmaceutical ingredient, strength, trade name as well as type and amount of the excipients. A total of 108 neonates were recruited and 97.2% of them were exposed to at least one PHE. Parabens (47.2%) and sulfites (27.5%) were the two most commonly administered PHEs. Benzyl alcohol is contraindicated in neonates but was administered to 8% of neonates in this study. The median daily dose of ethanol (24.11 mg/kg/day, IQR 19.73, 28.49) exceeded the acceptable daily intake (ADI) by four times. However, the dose was not available for all PHEs as this information is not always available in the PIL or SPC. Administration of cardiovascular drugs was associated with a higher risk of exposure to any PHE (OR 6.38, CI 2.75, 14.79, p-value < 0.001). The exposure of PHE among neonates in this study is high with certain PHEs exceeding the ADI. It highlights the need for certain strategies to be implemented to reduce such exposure in neonates.
sj-pdf-1-tam-10.1177_1758835920982845 – Supplemental material for Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis
Creators: name: Zhu, Erjia
name: Dai, Chenyang
name: Xie, Huikang
name: Su, Hang
name: Hu, Xuefei
name: Li, Ming
name: Fan, Junqiang
name: Liu, Jinshi
name: Zhu, Quan
name: Zhang, Lei
name: Ke, Honggang
name: Chen, Chang
Publisher: name: SAGE Journals
Year: 2020
Subjects: Oncology and Carcinogenesis not elsewhere classified
Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-1-tam-10.1177_1758835920982845 for Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis by Erjia Zhu, Chenyang Dai, Huikang Xie, Hang Su, Xuefei Hu, Ming Li, Junqiang Fan, Jinshi Liu, Quan Zhu, Lei Zhang, Honggang Ke and Chang Chen in Therapeutic Advances in Medical Oncology
A QbD approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate
Creators: name: Ahammad, Shaik Riyaz
name: Narayanasamy, Damodharan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Cyclophosphamide, an active pharmaceutical ingredient (API), is accessible in monohydrate form and esteemed for its remarkable stability. Maintaining this monohydrate form post-lyophilization is essential for product stability. This research aims to optimize essential lyophilization parameters for an effective and robust lyophilization cycle using a Quality by Design (QbD) methodology. Initially, thermal analysis is performed to evaluate the thermal qualities of the product. The research defines critical process parameters (CPPs) and important quality attributes (CQAs), employing a systematic Quality by Design (QbD) methodology to establish the design space in accordance with the required Quality Target Product Profile (QTPP). The lyophilization parameters being examined are primary drying temperature, primary drying duration, and primary drying vacuum. Meticulous analysis of the results identifies an optimum formulation. The test product successfully preserves water content between 6 and 7%, hence confirming the existence of the monohydrate form, as verified by X-ray diffraction (XRD) examination. Furthermore, the product demonstrates minimal concentrations of TBA and ACN, maintains an intact cake structure, and achieves a rapid reconstitution time of less than 30 s. The implementation of Quality by Design (QbD) concepts to enhance lyophilization parameters offers significant insights for developing generic pharmaceutical lyophilization formulations. Ultimately, a reliable freeze-drying technique is developed and then requires validation on industrial-scale lyophilizers for commercial applications.
E02790: Two letters of Pope Gregory the Great (Register 1.18 and 13.3), of 591 and 602, mention a monastery of saint *Adrianus (presumably Adrianos, martyr of Nicomedia, S01342) in Palermo (Sicily). Written in Latin in Rome.
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Pope Gregory the Great, Register of Letters 1.18

From the opening of the letter:

GREGORIVS PETRO SVBDIACONO
Insinuatum nobis est Marcellum Barunitanae ecclesiae, ibidem in ciuitate Panormitana in monasterio sancti Adriani in paenitentiam deputatum, non solum uictus necessitatem pati, sed et nuditatis nimiam sustinere molestiam.

'Gregory to Peter subdeacon
It has been suggested to us that Marcellus of the church of Barunitum, sent for penance to the monastery of Saint Adrianus in the same city of Palermo, was not only suffering a shortage of life's necessities, but was also enduring the excessive hardship of a lack of clothing.'

Pope Gregory the Great, Register of Letters 13.3

Extract from a letter to the monk Adeodatus:

Quia igitur, priusquam in monasterio sancti Adriani, ubi es conversus, intrares [...]

'Therefore, before you entered the monastery of Saint Adrianus, where you became a monk ...'

Text: Norberg 1982, vol. 1, 17 and vol. 2, 995. Translation: Martyn 2004, vol. 1, 132, and vol. 3, 824, lightly modified.
A QbD Approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate.
Creators: name: Ahammad, Shaik Riyaz
name: Narayanasamy, Damodharan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Cyclophosphamide, an active pharmaceutical ingredient (API), is accessible in monohydrate form and esteemed for its remarkable stability. Maintaining this monohydrate form post-lyophilization is essential for product stability. This research aims to optimize essential lyophilization parameters for an effective and robust lyophilization cycle using a Quality by Design (QbD) methodology. Initially, thermal analysis is performed to evaluate the thermal qualities of the product. The research defines critical process parameters (CPPs) and important quality attributes (CQAs), employing a systematic Quality by Design (QbD) methodology to establish the design space in accordance with the required Quality Target Product Profile (QTPP). The lyophilization parameters being examined are primary drying temperature, primary drying duration, and primary drying vacuum. Meticulous analysis of the results identifies an optimum formulation. The test product successfully preserves water content between 6-7%, hence confirming the existence of the monohydrate form, as verified by X-ray diffraction (XRD) examination. Furthermore, the product demonstrates minimal concentrations of TBA and ACN, maintains an intact cake structure, and achieves a rapid reconstitution time of less than 30 seconds. The implementation of Quality by Design (QbD) concepts to enhance lyophilization parameters offers significant insights for developing generic pharmaceutical lyophilization formulations. Ultimately, a reliable freeze-drying technique is developed and then requires validation on industrial-scale lyophilizers for commercial applications.
Meteoric Iron in Ancient Egyptian and Chinese Cultures  -  Pyramids, Meteorites and Circumpolar Stars
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2024
Subjects: China
Egypt
Meteoric iron
Jade meteorite
Tutankhamun's dagger
Kamil Crater
Alan Alford
Hongshan Culture
Akhet Khufu
Great Pyramid
Pyramid texts
Iron throne
Khufu
Pyramids
Big Dipper
C-dragon
Pig-dragon
Archaeoastronomy

description: Before the Iron Age, that is before the advent of iron smelting, the main source of the metal was meteoric iron. Here we propose a discussion about the use of this iron to make artifacts by people of ancient Egypt and China. For Egypt, we will report as the meteoric iron appeared, according to the British writer Alan Alford,  in the Pyramid Texts. It is also told that of iron was made one of the ritual tools used during the “opening of the mouth ceremony”, an ancient Egyptian ritual described in funerary texts. One of the shapes of this tool resembled the asterism of the circumpolar stars of the Big Dipper. The iron of Tutankhamun’s dagger and of the Kamil Crater will be discussed too. Then, we will consider China, where meteoric iron was forged onto the blades of bronze weapons.  We will discuss also the Hongshan Culture, famous for its jade artifacts. Modern artifacts, defined as Hongshan iron meteorites, show asterisms (the Big Dipper and Cassiopeia) carved on them, but the literature that we will mention here, about this Chinese neolithic culture, is not stressing any use of meteorites. In any case, it is true that the Nine Stars of the Big Dipper have been represented by Neolithic China. For what concerns the meteorites, as in the ancient Egypt, people of China considered the heavens as the source of meteoric iron. 

Contents: Sidereus Nuncius - Sign N41 and the Pyramid Texts -The big void in Akhet Khufu - In the secret repository - Whatever it is - Caliph Al Ma’mun and his father  - Shafts and Heaven’s Doors - Iron throne and sceptre – Charlemagne – The body - The Pindar’s iron throne – During the Early Iron Age - From the Guide of British Museum (1904) – Horus - Glittering in the nightly sky -  The Bull’s Leg -  The metal of Seth - ‘Opening of the Mouth and Eyes’ ritual - The second Khufu solar boat – Black-market and Kamil Crater  - Other non destructive analyses – A gift from Mitanni? - Kharga Oasis origin - The necklace from Gerzeh - Origin of the words – Stone and Fire –  Benben and Bennu, the Phoenix - Meteoric Iron? - Iron or copper? - Emperor Jahangir's meteorite blade - From Egypt to China – Layers on the bronze blades - Shang and Zhou - Meteoric Iron and Amulets - Hongshan Meteorite Iron? - The Nine Stars of the Big Dipper – Supernova - Pig-dragon - The “secret” Hongshan culture  - The C-dragon – Rituals –  Dream Pool Essays - Additional Information: Latin literature about meteorites - Sacred meteorites  - “Black iron of heaven from sky” in the treasure of a Hittite king -  Artifact of Meteoric Iron -   About Copper in Egypt – Sword and ring from celestial iron (J. R. R. Tolkien) - Meteoric iron talismans in Shangshung - An expert’s guide to meteorites
NOVAFOODIES official flyer IT
Creators: name: SPES
Publisher: name: Zenodo
Year: 2024

description: Sviluppo di sistemi innovativi diproduzione di alimenti funzionalicaratterizzati da una filiera piùsostenibile di materie prime marine ed'acqua dolce, come macro/microalghe e diverse specie ittiche,per consumatori europei piùconsapevoli.
Additional file 1 of Impact of multimodal intraoperative neurophysiological monitoring of the spinal cord during spine and spinal cord surgeries
Creators: name: Elwakil, Walaa
name: Imam, Mohamed
name: Hassan, Marwa
name: Elsaadany, Waleed
name: Gaber, Omnia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology

description: Additional file 1: Supplementary 1. Type of changes IONM changesduring spine/ spinal cord surgeries.
title: Das Pflichtexemplar in Hessen
Creators: name: Hammer, Angela
name: Kirschberger, Timo
name: Mayer, Martin
Publisher: name: University of Kassel
publisherIdentifier: https://ror.org/04zc7p361
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Pflicht
subject: E-Pflicht
subject: Pflichtexemplar
subject: elektronisches Pflichtexemplar
subject: Hessen
subject: Gesetz
subject: Geschichte
subject: Bestandserhaltung
subject: Webarchivierung
subject: mandatory copy
subject: electronic deposit copy
subject: e-requirement
subject: Hesse
subject: legal obligation
subject: history
subject: conservation
subject: web archiving
classificationCode: 020
subject: 020
classificationCode: Hessen
subject: Hessen
classificationCode: Pflichtexemplar
subject: Pflichtexemplar
classificationCode: Elektronische Publikation
subject: Elektronische Publikation
classificationCode: Gesetz
subject: Gesetz
classificationCode: Bestandserhaltung
subject: Bestandserhaltung
classificationCode: Archivierung
subject: Archivierung

description:
Der vorliegende Beitrag gibt einen Überblick über die historische Entwicklung, die aktuellen gesetzlichen Grundlagen, die Rolle der Pflicht für die Bestandserhaltung sowie die Struktur der E-Pflicht in Hessen.

description:
In this brief overview, the historical development, current legal foundations, the role of the collection mandate for stock conservation, and the structural basis of the e-requirement in Hesse are explained.
E02793: Augustine of Hippo (North Africa), preaches in Latin a sermon for the feast of Quadratus (martyr and bishop of Utica, one of the *Martyrs of Massa Candida, S00904), celebrated four days after that of the *Martyrs of Massa Candida (S01324). Sermon 306C, preached probably c. 397.
Creators: name: Robert
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Augustine of Hippo, Sermon 306C

[Sermo sancti Augustini episcopi ad mensam Cypriani de sancto Quadrato

'Sermon of Saint Augustine the Bishop at the Table of Saint Cyprian on Saint Quadratus']

1. Hoc discens et docens iste Quadratus – erat enim episcopus – cuius sollemnitatem hodie celebramus, cum tota plebe sua, clericis et laicis, confessus est Christum. Praemisit gregem, quem pascebat: post quadriduum Quadratus secutus est. Massa enim Candida, cuius ante quadriduum sollempnitas celebrata est, plebs erat Dei, gubernationi huius credita. Quam magnum parietem signinarium regebat iste Quadratus.

'Quadratus, whose feast we are celebrating today, both learned and taught his lesson - he was a bishop, you see - and with his whole people, clergy and laity, confessed Christ. He sent the flock on ahead, which he had been pasturing; four days later Quadratus followed them. The Shining White Mass (Massa Candida), you see, whose feast was celebrated four days ago, was the people of God entrusted to this man's care. What a splendid wall for wall posters this Quadratus had presided over.'

In the next passage of the sermon (§ 2) Augustine comments upon Quadratus' name, which denotes firmness. The rest of the sermon does not refer to him anymore.

Text: Morin 1930, 646. Translation: Hill 1994, 36. Summary: Robert Wiśniewski.
Additional file 1 of Linking the flow-induced tremor model to the seismological observation: application to the deep harmonic tremor at Hakone volcano, Japan
Creators: name: Ozaki, Tomonori
name: Yukutake, Yohei
name: Ichihara, Mie
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Additional file 1. Delivation of the basic equations.
Meteoric Iron in Ancient Egyptian and Chinese Cultures
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2021
Subjects: China
Egypt
Meteoric iron
Jade meteorite
Tutankhamun's dagger
Kamil Crater
Alan Alford
Hongshan Culture
Akhet Khufu
Great Pyramid
Pyramid texts
Iron throne
Khufu
Pyramids
Big Dipper

description: Before the Iron Age, that is before the advent of iron smelting, the main source of the metal was meteoric iron. Here we propose a discussion about the use of this iron to make artifacts by people of ancient Egypt and China. For Egypt, we will report as the iron is appearing, according to Alan Alford, in the Pyramid Texts. The iron of Tutankhamun’s dagger and of Kamil Crater will be discussed too. Then, we will consider China and in particular the Hongshan Culture, famous for its jade artifacts. Modern artifacts, defined as Hongshan iron meteorites, show asterisms (the Big Dipper and Cassiopeia) carved on them, but the literature that we will mention here, about this Chinese neolithic culture, is not stressing any use of meteorites. In any case, it is true that the Nine Stars of the Big Dipper have been represented by Neolithic China. For what concerns meteorites, it is possible that, as in ancient Egypt, people of Neolithic China had considered the stars as the source of meteoric iron.
 Contents: Sidereus Nuncius - Sign N41 and the Pyramid Texts -The big void in Akhet Khufu - Shafts and Heaven’s Doors - Iron throne and sceptre - Glittering in the nightly sky - The second Khufu solar boat – Black-market and Kamil Crater - Other non destructive analyses – The necklace from Gerzeh - Origin of the words - From Egypt to China - Meteoric Iron and Amulets - Shang and Zhou - Hongshan Meteorite Iron? - The Nine Stars of the Big Dipper – Pig-dragon - The “secret” Hongshan culture - The C-dragon
Modified sodium caseinate-based nanomicelles for enhanced chemotherapeutics against breast cancer via improved cellular uptake and cytotoxicity
Creators: name: Rehan, Farah
name: Karim, Md Emranul
name: Ahemad, Nafees
name: Qureshi, Omer Salman
name: Jelani, Seemal
name: Gan, Siew Hua
name: Chowdhury, Ezharul Hoque
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Poor prognosis, drug resistance, and lower drug loading capacity of the delivery systems lead to therapeutic failures of breast cancers. Herein, we functionalized sodium caseinate nanomicelles (NaCNs) with the divalent calcium (Ca2+) and the glucose (Glc) to increase the loading capacity of micelles for higher cellular uptake and cytotoxicity against breast cancer cells. Modification of casein micelles was confirmed through Fourier transform infrared spectra (FTIR). Triple quadrupole liquid chromatography–mass spectrometry (TQOF-LCMS/MS) was utilized as a simple, rapid, and sensitive method for protein corona quantification around casein through SwissProt.Mus_musculus database and through de novo sequencing. Un-modified and modified casein micelles were further characterized through field emission scanning electron microscope (FESEM), high resolution-transmission electron microscope (HR-TEM), and energy-dispersive X-ray (EDX). Whereas, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was used for protein separation and analysis during micelles formation. Calcium divalent modified sodium caseinate nanomicelles (Ca-NaCNs) and glucose-modified sodium caseinate nanomicelles (Glc-NaCNs) were successfully developed, demonstrating a significantly improved micellar stability. Glc-NaCNs-DOX showed a zeta size of 297.13 ± 15.66 nm with an improved zeta potential of −13.73 ± 0.579 with a drug loading efficiency (DLE) of 86% as compared to our previously published casein formulations since the modified versions involved more soluble casein in the protein micelle matrix, Whereas, Ca-NaCNs-DOX also showed an IC50 value of approximately 197.1 nm as compared to IC50 of free DOX (341.8 nm) and when compared to unmodified DOX loaded formulations (p < .001). Modified NaCNs exhibit the potential to be investigated further as a novel delivery system for similar active moieties to maximize their therapeutic effects.
Meteoric Iron in Ancient Egyptian and Chinese Cultures
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2021
Subjects: China
Egypt
Meteoric iron
Jade meteorite
Tutankhamun's dagger
Kamil Crater
Alan Alford
Hongshan Culture
Akhet Khufu
Great Pyramid
Pyramid texts
Iron throne
Khufu
Pyramids
Big Dipper
C-dragon

description: Before the Iron Age, that is before the advent of iron smelting, the main source of the metal was meteoric iron. Here we propose a discussion about the use of this iron to make artifacts by people of ancient Egypt and China. For Egypt, we will report as the iron is appearing, according to Alan Alford, in the Pyramid Texts. The iron of Tutankhamun’s dagger and of Kamil Crater will be discussed too. Then, we will consider China and in particular the Hongshan Culture, famous for its jade artifacts. Modern artifacts, defined as Hongshan iron meteorites, show asterisms (the Big Dipper and Cassiopeia) carved on them, but the literature that we will mention here, about this Chinese neolithic culture, is not stressing any use of meteorites. In any case, it is true that the Nine Stars of the Big Dipper have been represented by Neolithic China. For what concerns meteorites, it is possible that, as in ancient Egypt, people of Neolithic China had considered the stars as the source of meteoric iron.
 Contents: Sidereus Nuncius - Sign N41 and the Pyramid Texts -The big void in Akhet Khufu - Shafts and Heaven’s Doors - Iron throne and sceptre - Glittering in the nightly sky - The second Khufu solar boat – Black-market and Kamil Crater - Other non destructive analyses – The necklace from Gerzeh - Origin of the words - From Egypt to China - Meteoric Iron and Amulets - Shang and Zhou - Hongshan Meteorite Iron? - The Nine Stars of the Big Dipper – Pig-dragon - The “secret” Hongshan culture - The C-dragon
Meteoric Iron in Ancient Egyptian and Chinese Cultures
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2021
Subjects: China
Egypt
Meteoric iron
Jade meteorite
Tutankhamun's dagger
Kamil Crater
Alan Alford
Hongshan Culture
Akhet Khufu
Great Pyramid
Pyramid texts
Iron throne
Khufu
Pyramids
Big Dipper
C-dragon
Pig-dragon

description: Before the Iron Age, that is before the advent of iron smelting, the main source of the metal was meteoric iron. Here we propose a discussion about the use of this iron to make artifacts by people of ancient Egypt and China. For Egypt, we will report as the iron is appearing, according to Alan Alford, in the Pyramid Texts. The iron of Tutankhamun’s dagger and of Kamil Crater will be discussed too. Then, we will consider China and in particular the Hongshan Culture, famous for its jade artifacts. Modern artifacts, defined as Hongshan iron meteorites, show asterisms (the Big Dipper and Cassiopeia) carved on them, but the literature that we will mention here, about this Chinese neolithic culture, is not stressing any use of meteorites. In any case, it is true that the Nine Stars of the Big Dipper have been represented by Neolithic China. For what concerns meteorites, it is possible that, as in ancient Egypt, people of Neolithic China had considered the stars as the source of meteoric iron.
 Contents: Sidereus Nuncius - Sign N41 and the Pyramid Texts -The big void in Akhet Khufu - Shafts and Heaven’s Doors - Iron throne and sceptre - Glittering in the nightly sky - The second Khufu solar boat – Black-market and Kamil Crater - Other non destructive analyses – The necklace from Gerzeh - Origin of the words - From Egypt to China - Meteoric Iron and Amulets - Shang and Zhou - Hongshan Meteorite Iron? - The Nine Stars of the Big Dipper – Pig-dragon - The “secret” Hongshan culture - The C-dragon
Additional file 1 of PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs
Creators: name: Vochteloo, Martijn
name: Deelen, Patrick
name: Vink, Britt
name: Tsai, Ellen A.
name: Runz, Heiko
name: Andreu-Sánchez, Sergio
name: Fu, Jingyuan
name: Zhernakova, Alexandra
name: Westra, Harm-Jan
name: Franke, Lude
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figs. S1-S23. Supplementary figures including legends.
Quality by design (QbD) based approach for development of itraconazole-loaded transferosomes for skin cancer: in vitro, ex vivo and cell line studies
Creators: name: Kudi, Priya
name: Sen, Srijita
name: Murkute, Satyajit
name: Mohapatra, Purusottam
name: Ranjan, Om Prakash
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Itraconazole (ITZ), a widely used systemic antifungal drug, has been ingeniously repurposed for its antitumor effects. In the present work, we have prepared and optimized the ITZ-loaded transferosomes by Quality by Design (QbD) approach and repurposed them for skin cancer. The transferosomal formulation was optimized by employing a QbD approach with the design of experiment. A combination of screening and optimization design was used for formulation optimization. The optimized formulation was characterized by particle size, PDI, zeta potential, FTIR, XRD, and surface morphology using TEM. In vitro and ex vivo studies were performed using Franz diffusion cells. An in vitro cell line study was performed on the human melanoma A375 cell line. The optimized formulation has a particle size of 192.37 ± 13.19 nm, PDI of 0.41 ± 0.03, zeta potential −47.80 ± 3.66, and an entrapment efficiency of 64.11 ± 3.75%. In vitro release studies showed that ITZ encapsulated transferosomes offer higher and sustained release than pure drugs. Ex vivo drug penetration and retention studies show that the penetration and retention of transferosomes are more visible in the skin than in the drug. The cell viability study confirms that ITZ encapsulated transferosomes have almost 2-fold more potency against the A375 cell line than pure drug. ITZ encapsulated transferosomes were successfully prepared and optimized using a combination of screening and optimization designs. Based on ex vivo and cell line studies, we conclude that ITZ-loaded transferosomes could aid melanoma management alongside standard therapies.
Quality by design (QbD) based approach for development of itraconazole loaded transferosomes for skin cancer: In vitro, ex vivo and cell line studies
Creators: name: Kudi, Priya
name: Sen, Srijita
name: Murkute, Satyajit
name: Mohapatra, Purusottam
name: Ranjan, Om Prakash
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Itraconazole (ITZ), a widely used systemic antifungal drug, has been ingeniously repurposed for its antitumor effects. In the present work, we have prepared and optimized the ITZ-loaded transferosomes by Quality by Design (QbD) approach and repurposed them for skin cancer. The transferosomal formulation was optimized by employing a QbD approach with the design of experiment. A combination of screening and optimization design was used for formulation optimization. The optimized formulation was characterized by particle size, PDI, zeta potential, FTIR, XRD, and surface morphology using TEM. In vitro and ex vivo studies were performed using Franz diffusion cells. An in vitro cell line study was performed on the human melanoma A375 cell line. The optimized formulation has a particle size of 192.37 ± 13.19 nm, PDI of 0.41 ± 0.03, zeta potential -47.80 ± 3.66, and an entrapment efficiency of 64.11 ± 3.75%. In vitro release studies showed that ITZ encapsulated transferosomes offer higher and sustained release than pure drugs. Ex vivo drug penetration and retention studies show that the penetration and retention of transferosomes are more visible in the skin than in the drug. The cell viability study confirms that ITZ encapsulated transferosomes have almost 2-fold more potency against the A375 cell line than pure drug. ITZ encapsulated transferosomes were successfully prepared and optimized using a combination of screening and optimization designs. Based on ex vivo and cell line studies, we conclude that ITZ-loaded transferosomes could aid melanoma management alongside standard therapies.