title: ÐÐ¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð·Ð¸ÑÑÐ¾Ð½Ð½Ð¾Ð¹ ÑÐ¼Ð¸ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¾Ð¼Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð² Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ð¸ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ°ÑÐºÐ¸Ð½ÑÐ¾Ð½Ð° Ð¿ÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° [18F]Ð¤ÐÐ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Possibilities of positron emission tomography in identifying mechanisms of Parkinsons disease development using [18F]FDG radiopharmaceuticals
Creators: name: ÐÑÑÐ½Ð¸Ðº, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÐÐ°ÑÐºÐ¸Ð½ÑÐ¾Ð½Ð°
Ð°Ð»ÑÑÐ°-ÑÐ¸Ð½ÑÐºÐ»ÐµÐ¸Ð½
Ð¿Ð¾Ð·Ð¸ÑÑÐ¾Ð½Ð½Ð°Ñ ÑÐ¼Ð¸ÑÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ¾Ð¼Ð¾Ð³ÑÐ°ÑÐ¸Ñ
ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð°ÑÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÐ¹ Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ
ÑÐ°Ð´Ð¸Ð¾ÑÑÐµÐ¹ÑÐµÑ
Parkinsons disease
alpha-synuclein
positron emission tomography
radiopharmaceutical drug product
radiotracer

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ°ÑÐºÐ¸Ð½ÑÐ¾Ð½Ð° (ÐÐ) Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¿Ð¾Ð·Ð¸ÑÑÐ¾Ð½Ð½Ð¾Ð¹ ÑÐ¼Ð¸ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¾Ð¼Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ (ÐÐ­Ð¢) Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¼ÐµÑÐµÐ½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¾Ð³Ð° Ð³Ð»ÑÐºÐ¾Ð·Ñ [18F]Ð¤ÐÐ. ÐÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ Ð´ÐµÑÐµÑÐ¼Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð° Ð²ÑÑÐ¾ÐºÐ¾Ð¹ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð½Ð¾ÑÑÑÑ ÐÐ, Ð¿ÑÐ¸Ð²Ð¾Ð´ÑÑÐµÐ³Ð¾ Ðº Ð¸Ð½Ð²Ð°Ð»Ð¸Ð´Ð¸Ð·Ð°ÑÐ¸Ð¸. Ð¦ÐµÐ»Ñ ÐÐÐ  â Ð¿ÑÐ¾Ð²ÐµÑÐºÐ° ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð³Ð¸Ð¿Ð¾ÑÐµÐ·Ñ Ð¾ Ð´Ð²ÑÑ Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ°Ñ Ð²Ð¾Ð·Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ ÐÐ Ð½Ð° Ð¾ÑÐ¾Ð±ÑÐ°Ð½Ð½ÑÑ Ð³ÑÑÐ¿Ð¿Ð°Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð²Ð¾ÑÑÐ¾Ð´ÑÑÐ¸Ð¼ Ð¸ Ð½Ð¸ÑÑÐ¾Ð´ÑÑÐ¸Ð¼ ÑÐ¸Ð¿Ð¾Ð¼ ÑÐµÑÐµÐ½Ð¸Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸. Ð Ð³ÑÑÐ¿Ð¿Ðµ Ð±Ð¾Ð»ÑÐ½ÑÑ Ñ ÐÐ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð°ÑÑ ÐÐ­Ð¢ Ñ ÑÐ°Ð´Ð¸Ð¾ÑÑÐµÐ¹ÑÐµÑÐ¾Ð¼ [18F]Ð¤ÐÐ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¾Ð±ÑÐ°Ð±Ð°ÑÑÐ²Ð°Ð»Ð¸ÑÑ Ð½Ð° ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐµ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð¸ÐµÐ¼ ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð´Ð»Ñ ÐÐ Ð¿Ð°ÑÑÐµÑÐ½Ð°, Ð¿Ð¾ÑÐ»Ðµ ÑÐµÐ³Ð¾ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»ÑÑ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·. ÐÑÐ»Ð¸ ÑÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð³ÑÑÐ¿Ð¿Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ðµ Ð³ÑÑÐ¿Ð¿Ð°Ð¼ Ð²Ð¾ÑÑÐ¾Ð´ÑÑÐµÐ³Ð¾ Ð¸ Ð½Ð¸ÑÑÐ¾Ð´ÑÑÐµÐ³Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ SOC-model. ÐÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð½Ð°Ð»Ð¸ÑÐ¸Ñ Ð»Ð°ÑÐµÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð°ÑÑÐµÑÐ½Ð° Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ ÑÐ¸Ð¿Ð°Ð¼Ð¸ ÑÐµÑÐµÐ½Ð¸Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ°ÑÐºÐ¸Ð½ÑÐ¾Ð½Ð° Ð² Ð¸Ð·ÑÑÐ°ÐµÐ¼Ð¾Ð¹ Ð²ÑÐ±Ð¾ÑÐºÐµ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð¼ Ð¿ÑÐ¾Ð²ÐµÑÐºÐ¸ ÑÑÐ°Ð»Ð¾ Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸Ðµ Ð¾Ð± Ð¾ÑÑÑÑÑÑÐ²Ð¸Ð¸ Ð»Ð°ÑÐµÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð°ÑÑÐµÑÐ½Ð°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ²Ð»ÑÑÑÑÑ Ð¿ÑÐµÐ´Ð²Ð°ÑÐ¸ÑÐµÐ»ÑÐ½ÑÐ¼Ð¸. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ»ÐµÐ´ÑÐµÑ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ´Ð¸ÑÑ Ð² Ð±Ð¾Ð»ÐµÐµ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ðµ, Ð¿ÑÐ¸ ÑÑÐ¾Ð¼ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð°Ñ Ð² ÐÐÐ  Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ.
description: The work is devoted to the diagnosis of Parkinsons disease (PD) by positron emission tomography (PET) using labeled glucose analog [18F]FDG. The relevance of the work is determined by the high prevalence of PD leading to disability. The aim of the work is to test the modern hypothesis about two sources of PD occurrence on selected groups of patients with ascending and descending type of the disease course. PET with [18F]FDG radiotracer was performed in the group of patients with PD, the obtained images were preprocessed on the computer with subsequent isolation of the PD-specific pattern, after which statistical analysis was performed. Patient groups corresponding to ascending and descending disease course according to the SOC-model classification were formed. The presence of pattern lateralization in patients with different types of Parkinsons disease course in the studied sample was analyzed. The verification resulted in the conclusion that there was no pattern lateralization. The results obtained are preliminary. The results should be confirmed in a larger group, using the research methodology developed in the work.