title: ÐÐ·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð´ÐµÐ¿Ð¾-ÑÐ¿ÑÐ°Ð²Ð»ÑÐµÐ¼Ð¾Ð³Ð¾ Ð²Ñ Ð¾Ð´Ð° ÐºÐ°Ð»ÑÑÐ¸Ñ Ð¿ÑÐ¸ Ð´Ð¸Ð°Ð±ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð½ÐµÑÑÐ¾Ð¿Ð°ÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Alteration of store-operated calcium entry in diabetic nephropathy
Creators: name: ÐÐ°ÐºÐµÑÐ½Ð¾Ðº, Ð¡Ð¾ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ»ÐµÑÐºÐ° (Ð±Ð¸Ð¾Ð».)
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description: The given work is devoted to the study of the store-operated calcium entry in podocytes of freshly isolated rat glomeruli. Previously diabetes has been induced in these rats and nephropathy development was confirmed by changes in the clinical parameters of the rats. Glomerules were isolated from the kidneys by differential sieving method. The relative cytoplasmic calcium concentration was estimated using Fura-2 AM fluorescent indicator. The main results of the studies are the detection (1) changes of store-operated calcium entry, (2) alteration of calcium quantity in the store and (3) variation of the extent of basal activity of calcium entry in podocytes of rats with type 2 diabetes. Changes pattern depended on the stage of development of diabetic nephropathy. Store-operated calcium entry is insufficiently studied in podocytes, therefore the results can be used for further experiments for additional investigation by other methods. The facts obtained in this work can be applied to correction of the existing therapy for diabetic nephropathy. As well as these evidences will be used as supplement for already known information about molecular disorders in the development of the disease.