cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Thermodynamic and separation properties of 4-(octyloxy) benzoic acid liquid crystals by inverse gas chromatography (IGC)
Creators: name: Isik, Birol
name: Cakar, Fatih
name: Cankurtaran, Husnu
name: Cankurtaran, Ozlem
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: The thermodynamic properties of 4-(octyloxy) benzoic acid (OBA) liquid crystal (LC) were investigated at infinite dilution by inverse gas chromatography (IGC). The phase transition temperatures of OBA LC were determined by differential scanning calorimetry (DSC) and IGC. The thermodynamic region was determined to be between 160 and 170 °C. Specific retention volumes were calculated using IGC measurements to prepare retention diagrams. The results from the diagrams were used to characterize the thermodynamic properties of the OBA LCs. Based upon these properties, the solvents used in this study were determined to be unsuitable for OBA LCs. The separation of structural isomer series (butyl acetate, butyl alcohol, and amyl alcohol series) was studied by an OBA LC coated Chromosorb W stationary phase in the thermodynamic region. This system was able to distinguish the isomers according to the determined selectivity coefficients.
Capmatinib: First Approval
Creators: name: Sohita Dhillon
Publisher: name: Adis Journals
Year: 2021
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Sohita Dhillon is a contracted employee of Adis International Ltd/Springer Nature and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here

AbstractCapmatinib (Tabrecta™) is an oral, small molecule mesenchymal-epithelial transition (MET) inhibitor being developed by Novartis Oncology, under a license from Incyte Corporation, for the treatment of lung cancer. Capmatinib targets and selectively binds to MET, including the mutant variant produced by exon 14 skipping, and inhibits cancer cell growth driven by the mutant MET variant. In May 2020, oral capmatinib received its first global approval in the USA for the treatment of adults with metastatic non-small cell lung cancer (NSCLC) whose tumours have a mutation that leads to MET exon 14 skipping, as detected by an FDA-approved test. Clinical development for the treatment of glioblastoma, liver cancer, malignant melanoma, breast cancer, colorectal cancer, head and neck cancer and solid tumours is ongoing in several countries. This article summarizes the milestones in the development of capmatinib leading to its first approval.

© Springer Nature Switzerland AG 2021
Cómo fomentar la equidad de género en las organizaciones
Creators: name: Ortiz, Francisco
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 440504
subject: Gender relations

description: La equidad de género en las organizaciones es un objetivo relevante para promover la igualdad de oportunidades y la inclusión en el ámbito laboral. A pesar de los avances hacia la igualdad de género en las últimas décadas, persisten desafíos significativos en torno a la equidad salarial, las barreras para el avance profesional y la existencia del llamado techo de cristal, que limita el acceso de las mujeres a puestos de liderazgo.Este artículo analiza cómo la implementación de políticas de equidad mejora la productividad, fomenta la innovación y fortalece la reputación corporativa. A nivel cultural, se evidencia que los entornos laborales inclusivos promueven la colaboración, reducen conflictos internos y refuerzan los valores de respeto y diversidad.A través de un análisis y estudios recientes, se demuestra que la equidad de género no solo es una responsabilidad ética, sino también una estrategia clave para lograr un desempeño sostenible y un ambiente de trabajo más saludable. Este estudio ofrece recomendaciones prácticas para que las organizaciones generen un impacto positivo en su cultura y en el bienestar de sus equipos.
Additional file 1 of Estimating malaria antigen dynamics and the time to negativity of next-generation malaria rapid diagnostic tests
Creators: name: Sheahan, William
name: Golden, Allison
name: Barney, Rebecca
name: Das, Smita
name: Jang, Ihn-Kyung
name: Ntuku, Henry
name: Wu, Xue
name: Whittemore, Brooke
name: Dausab, Lucille
name: Mumbengegwi, Davis
name: Domingo, Gonzalo J.
name: Hsiang, Michelle S.
name: Slater, Hannah
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1
Raman spectroscopy study of NaxCoO2 and superconducting NaxCoO2.yH2O
Creators: name: Shi, Y. G.
name: Liu, Y. L.
name: Yang, H. X.
name: Nie, C. J.
name: Jin, R.
name: Li, J. Q.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The Raman spectra of the parent compound NaxCoO2 (x=0.75) and the superconducting oxyhydrates NaxCoO2.yH2O with different superconducting temperatures (Tc) have been measured. Five Raman active phonons around 195 cm-1 (E1g), 482 cm-1, 522 cm-1, 616 cm-1 (3E2g), 663 cm-1 (A1g) appear in all spectra. These spectra change systematically along with the intercalation of H2O and superconducting properties. In particular, the Raman active phonons (A1g and E1g) involving the oxygen motions within the Co-O layers show up monotonous decrease in frequency along with superconducting temperature Tc. The fundamental properties and alternations of other active Raman phonons in the superconducting materials have also been discussed.
description: 16 pages, 4 figures, 2 tables
The stripe phase in 4-leg ladders and quantum impurity entanglement
Creators: name: Chang, Ming-Shyang
Publisher: name: University of British Columbia
Year: 2011

description: The physics of ladder systems and the Kondo problem have an essentially one-dimensional nature. There are powerful tools, such as bosonization and conformal field theory, applicable to these systems. In the first part of this dissertation, the stripe phase in 4-leg ladders is investigated by bosonization and weak-coupling renormalization group equations. A new type of charge-four correlation, bipairing, is proposed and gives a simple explanation of the stripe phase. In the second part, we discuss boundary effects on the entanglement entropy in quantum spin chains and calculate the entanglement entropy in the Kondo-like quantum impurity model. The result on impurity entanglement entropy is generalized to the system with finite size or finite temperature by employing conformal field theory methods. The theoretical calculations are also compared with numerical results obtained by density matrix renormalization group methods.
Recovery of Agriculture from the Northern Nagano Prefecture Earthquake
Creators: name: Sekine, Kae
name: Sekine, Kae
Publisher: name: Unknown
Year: 2014
Subjects: subject: Risk and Uncertainty
subject: Northern Nagano Prefecture Earthquake
subject: the Village of Sakae
subject: recovery
subject: agriculture in hilly and mountainous areas
subject: participation of residents

description: A more than 6 JMA (Japanese Meteorological Agency Seismic Intensity Scale) earthquake hit northern Nagano Prefecture just one day after the Great Eastern Japan Earthquake of March 11, 2011. This paper employs the case of the Village of Sakae to: 1) illustrate the damage and recovery from the earthquake; 2) identify challenges to promote participation of residents in the planning for reconstruction; and 3) point out efforts generated for, but also challenges encountered in, the mobilization of local resources for reconstruction and the establishment of internal and external stakeholder networks. Based on original interviews, statistics and collected documents, this investigation establishes that not only did retirement from farming after the earthquake occur because of this natural disaster but it was also due to the deterioration of living conditions, the advanced age of the local population, and the decline of agricultural commodities' prices. As the reconstruction plan in the Village of Sakae centers on a policy of “participation by all," including small and family owned farms, it significantly departs from the policy of “creative reconstruction" or “shock doctrine." However a number of challenges to residents' participation remain and need to be addressed.
Characteristics of New Food Supply Action and Its Future Tasks in 3.11 Tsunami Disaster Areas
Creators: name: Ito, Fusao
name: Ito, Fusao
Publisher: name: Unknown
Year: 2014
Subjects: subject: Risk and Uncertainty
subject: tsunami disaster area
subject: restoration & revitalization
subject: agricultural land integration
subject: regional management
subject: acquisition of farming skills

description: To generate a discussion of the agricultural restoration and revitalization in the 3.11 Tsunami disaster area, we have arranged local government statistical data and analyzed interview data from farm managers. As the result, the following five points were found. First, the restoration progress of agricultural land and facilities has been delayed as compared with its scheme because most of the materials and labor are being used for construction in metropolitan areas. It is a serious problem for farmers to be provided infertile surface soil on their paddy fields. Second, agricultural structure reform is rapidly progressing in the tsunami disaster area as many large-scale farms are emerging through agricultural land integration. Third, some managers of large-scale farms positively introduced new technology to improve their productivity. They also have a future plan to maintain their community and to improve the inhabitants' welfare with diversified farming. Fourth, it is not easy to recover the market share that had been lost because of the 3.11 disaster. For agricultural revitalization, it is important to analyze the change in consumers' preferences and to cope with it. Finally, acquisition of farming skills is essential and most important to the new agricultural corporation that employs unskilled labor.
Gravitational Lensing Statistics in Universes Dominated by Dark Energy
Creators: name: Kuhlen, M.
name: Keeton, C. R.
name: Madau, P.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study lens statistics in flat, low-density universes with different equations of state $w=p_Q/ρ_Q$ for the dark energy component. Dark energy modifies the distance-redshift relation and the mass function of dark matter halos leading to changes in the lensing optical depth as a function of image separation. Those effects must, however, be distinguished from effects associated with the structure of dark matter halos. Baryonic cooling causes galaxy-mass halos to have different central density profiles than group- and cluster-mass halos, which causes the distribution of normal arcsecond-scale lenses to differ from the distribution of ``wide-separation'' ($Δθ\gtrsim 4\arcsec$) lenses. Fortunately, the various parameters related to cosmology and halo structure have very different effects on the overall image separation distribution: (1) the abundance of wide-separation lenses is exremely sensitive (by orders of magnitude) to the distribution of ``concentration'' parameters for massive halos modeled with the Navarro-Frenk-White profile; (2) the transition between normal and wide-separation lenses depends mainly on the mass scale where baryonic cooling ceases to be efficient; and (3) dark energy has effects at all image separation scales. While current lens samples cannot usefully constrain all of the parameters, ongoing and future imaging surveys should discover hundreds or thousands of lenses and make it possible to disentangle the various effects and constrain all of the parameters simultaneously. (abridged)
description: 15 pages, 11 figures, accepted for publication in ApJ
Subjects and Countermeasures against the Radioactive Contamination after the Great East Japan Earthquake
Creators: name: Monma, Toshiyuki
name: Monma, Toshiyuki
Publisher: name: Unknown
Year: 2014
Subjects: subject: Risk and Uncertainty
subject: Great East Japan Earthquake
subject: radioactive contamination
subject: reputational damage
subject: isk communication
subject: moral hazard

description: This paper summarizes the desirable future direction of the measures against reputational damages based on evaluating the current status of reputational damage, radioactive contamination and efforts to overcome the disaster which occurred with the Great East Japan Earthquake. Specifically, we evaluated the significance the following countermeasures against the reputational damages and radioactive contamination. 1) Building a mutual trust and assistance system among consumers and victims by using relationship marketing, 2) construction of a radioactivity risk management system with an emphasis on prevention and response when a disaster occurs, 3) rumor prevention by using risk communication, and 4) correspondence with moral hazard.
Additional file 1 of Creating value with eHealth: identification of the value proposition with key stakeholders for the resilience navigator app
Creators: name: Lentferink, Aniek
name: Polstra, Louis
name: D’Souza, Austin
name: Oldenhuis, Hilbrand
name: Velthuijsen, Hugo
name: Gemert-Pijnen, Lisette Van
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Online survey used for the stakeholder identification. This additional file includes the content of the online survey that was send to participants that contributed to the identification of the key stakeholders.
Model identification in $μ^-\to e^-$ conversion with invisible boson emission using muonic atoms
Creators: name: Uesaka, Yuichi
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this article, we investigate the $μ^-\to e^-X$ process in a muonic atom, where $X$ is a light neutral boson. By calculating the spectrum of the emitted electron for several cases, we discuss the model-discriminating power of the process. We report the strong model dependence of the spectrum near a high-energy endpoint. Our findings show that future experiments using muonic atoms are helpful to identify the properties of exotic bosons.
description: 9 pages, 7 figures
Quantitative Analysis of the Regional Income Determinant Factors in a Remote Island Economy: Generation and Application of a Regional Input-Output Table
Creators: name: Fujimoto, Takashi
name: Fujimoto, Takashi
Publisher: name: Unknown
Year: 2015
Subjects: subject: Public Economics
subject: remote island
subject: income determination model
subject: regional I-O table
subject: cross-hauling
subject: non-survey method

description: This study modeled income determination of a regional economy consisting of n types of industries, and decomposed regional income of the remote islands into the incomes induced by the central government spending and transfer payments, net income from outside of the region, export, consumption and investment independent from income. The result shows that 42-45% of the regional income depends on the fiscal expenditure of the central government. This study also proposed a non-survey method to generate a competitive import type regional input-output table from the prefectural one. This method assumes that (1) all regions in the prefecture assign an identical ratio of the ith product output to the export for outside the prefecture, and depend on outside the prefecture for an identical ratio of the ith product demand, and (2) the ratio of the intra-industry trade among the trade volume between regions in the prefecture is identical to that of between the prefecture and outside the prefecture.
Rational Curves in Calabi-Yau Threefolds
Creators: name: Johnsen, Trygve
name: Knutsen, Andreas Leopold
Publisher: name: arXiv
Year: 2003
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14J32 (14H45, 14J28)

description: We study the set of rational curves of a certain topological type in general members of certain families of Calabi-Yau threefolds. For some families we investigate to what extent it is possible to conclude that this set is finite. For other families we investigate whether this set contains at least one point representing an isolated rational curve.
description: In special volume dedicated to Steven L. Kleiman on his 60'th birthday. Contains revised version of Theorem 4.3
title: Studies on the specificities of In Vivo and In Vitro bioassays used in the potency determination of Therapeutic Erythropoietin
Creators: name: Liefooghe, Emily Claire
Publisher: name: The Open University
Year: 2006

description: Erythropoietin (Epo), a kidney-produced cytokine, promotes the proliferation and differentiation of erythroid progenitors into mature red blood cells.

The in vivo biological activity of Epo is dependent on it being adequately glycosylated. Glycosylation is a variable process and its precise effect on clearance mechanisms within the body has yet to be fully established. Studies have shown, however, that the loss of the terminal sialic acid residue, leading to exposure of the penultimate galactose residue, results in a dramatic reduction in activity, owing to the liver's galactose-dependent clearing action. Current in vitro cell-based bioassays for Epo are unaffected by such a phenomenon and therefore do not correlate with the invivo bioassays.

As part of this project, strategies were devised for rendering cell-based bioassays sensitive to sialylation. The strategies' common feature was the inclusion of a mechanism for depleting or sequestering desialylated Epo via a galactose-binding protein (derived from either plants or the human liver). The assays were tested usinga range of Epo samples desialylated to various degrees by neuraminidase treatment. This provided proof of principle that rational manipulation of in vitro hioassays rendering them sensitive to a factor known to affect in vivo activity can allow the prediction of bioactivity without the use of live animals.

Two Epo sample sets were investigated in addition to the neuraminidase-treated sample set - one produced by different culture and purification procedures, the other consisting of a batch of pharmaceutical-grade Epo separated into fractions by ion-exchange HPLC. Investigations were carried out by means of the most sensitive assay developed as well as a range of biological, biochemical and physico-chemical techniques with a view to producing an analytical and comparative study. The results suggested that the relationship between galactose exposure and in vivo biological activity might not be as straightforward as had been initially thought.
Land Speculation and Householder Polarization in the Mekong Delta of Vietnam: A Case Study in the Former Area of the Hoa Duc and Bau Mon Hamlets
Creators: name: Yamazaki, Ryoichi
name: Kamakawa, Akemi
name: Yamazaki, Ryoichi
name: Kamakawa, Akemi
Publisher: name: Unknown
Year: 2015
Subjects: subject: Land Economics/Use
subject: differentiation of farmers
subject: speculation
subject: land market
subject: Mekong Delta
subject: Vietnam

description: This paper describes the result of investigations and research studies conducted targeting the old site of Hoa Duc and Bau Mon Hamlets, Hoa An Village, Phung Hiep District in Hau Giang Province, Vietnam (Can Tho until 2002), which has been the site of an investigation by the authors since 1993. The authors conducted an entire household survey targeting more than three hundred households in the same area, four times in 1993, 1997, 2002, and 2011, in cooperation with Can Tho University. The authors also used the data gained from these investigations and analyzed actual conditions of the changes in agricultural structures in the target area and the causes of such changes. The research outcomes up to 1997 have already been released; thus, this paper describes the analytical outcomes of the period after that. As a result, the study found a trend in recent years involving a new situation that can be described as a twenty-first century-style differentiation and polarization of the farming population. This situation is new and completely different from the differentiation and polarization of the farming population governed by the disparity in productivity that was found in the analyses up to 1997. This is the differentiation and polarization of the farming population that is now significantly diverged from the growth of farming productivity as governed by the speculative characteristics of the land market, which moves under the strong influence of the input of excessive capital of developed countries. Such differentiation and polarization can be described as a falling trend of the overall farming population.
Spectral lags caused by the Doppler effect of fireballs
Creators: name: Lu, R. -J.
name: Qin, Y. -P.
name: Zhang, Z. -B.
name: Yi, T. -F.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recently, Shen et al. (2005) studied the contributions of curvature effect of fireballs to the spectral lag and showed that the observed lags could be accounted for by the effect. Here we check their results by performing a more precise calculation with both the formulas presented in Shen et al. (2005) and Qin et al. (2004). Several other aspects which were not considered in Shen et al. (2005) are investigated. We find that in the case of ultra-relativistic motions, both formulas are identical as long as the whole fireball surface is concerned. In our analysis, the previous conclusion that the detected spectral lags could be accounted for by the curvature effect is confirmed, while the conclusion that the lag has no dependence on the radius of fireballs is not true. We find that introducing extreme physical parameters is not the only outlet to explain those observed large lags. Even for the larger lags ($\sim5s$) (see Norris et al. 2005), a wider local pulse ($Δt_{θ,FWHM} = 10^{7}s$) could account for it. Some conclusions not presented in Shen et al. (2005) or those modified in our analysis are listed below: a) lag $\propto Γ^{-ε}$ with $ε>$ 2; b) lag is proportional to the local pulse width and the $FWHM$ of the observed light curves; c) a large lag requires a large $α_0$ and a small $β_0$ as well as a large $E_{0p}$; d) when the rest frame spectrum varies with time, the lag would become larger; e) lag decreases with the increasing of $ R_c$; f) lag $\propto$ E within the certain energy range for a given Lorentz factor; g) lag is proportional to the opening angle of uniform jets when $θ_j < 0.6Γ^{-1}$.
description: 26 pages, 18 figures, accepted for publication in MNRAS
Decitabine/Cedazuridine: First Approval
Creators: name: Sohita Dhillon
Publisher: name: Adis Journals
Year: 2021
Subjects: subject: Medicine
subject: 111206 Haematological Tumours
subject: FOS: Clinical medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.Conflict of interest Sohita Dhillon is a contracted employee of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest.Ethics approval, Consent to participate and consent for publication, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here

AbstractA fixed dose oral combination (FDC) of decitabine and cedazuridine (Inqovi®), is being developed by Astex Pharmaceuticals (a subsidiary of Otsuka Pharmaceuticals) for the treatment of various cancers like myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemia (AML), glioma and solid tumours. Decitabine, a DNA methyltransferase inhibitor approved for the treatment of MDS, is degraded by cytidine deaminase in the gastrointestinal tract and liver, thereby limiting oral bioavailability. Cedazuridine is a proprietary, patented cytidine deaminase inhibitor that, when added to decitabine, increases oral bioavailability of the drug. In July 2020, decitabine/cedazuridine received its first approval in the USA and Canada for the treatment of MDS and CMML. In the USA, it is indicated for use in adults with MDS, including previously treated and untreated, de novo and secondary MDS with the following French-American-British subtypes (refractory anaemia, refractory anaemia with ringed sideroblasts, refractory anaemia with excess blasts and CMML) and intermediate-1, intermediate-2 and high-risk International Prognostic Scoring System groups. Clinical studies for AML, glioma and solid tumours are underway in several countries worldwide. This article summarizes the milestones in the development of decitabine/cedazuridine leading to this first approval for the treatment of MDS and CMML.

© Springer Nature Switzerland AG 2020
COMMENT DÉTERMINER LE STADE DE RÉCOLTE DES FRUITS CLIMACTÉRIQUES DESTINÉS À L'EXPORT ? APPLICATION A UNE NOUVELLE VARIÉTÉ DE BANANE DESSERT
HOW TO DETERMINE THE OPTIMAL HARVEST STAGE OF CLIMACTERIC FRUIT FOR EXPORT: APPLICATION TO A NEW VARIETY OF BANANA
Creators: name: Paget, B.
name: Salmon, F.
name: Bugaud, C.
name: Paget, B.
name: Salmon, F.
name: Bugaud, C.
Publisher: name: Unknown
Year: 2007
Subjects: subject: Crop Production/Industries
subject: Research and Development/Tech Change/Emerging Technologies
subject: banane
subject: exportation
subject: stade de récolte
subject: intervalle floraison-jaunissement
subject: durée de vie verte

description: Le CIRAD a mis au point une méthode innovante basée sur la règle des sommes thermiques qui permet de déterminer le stade optimal de récolte des nouvelles variétés de bananes destinées à l'export. Les essais ont été menés sur une nouvelle variété créée par le CIRAD, la Flhorban 916, et sur une variété témoin, la Cavendish. Elles ont été implantées sur 2 sites caractérisés par des conditions pédoclimatiques différentes. Le stade de récolte de Flhorban 916 a été évalué en déterminant son zéro physiologique puis l'IFC qui procure à ses fruits une DVV optimale. Ce stade de récolte a enfin été expérimenté dans les conditions réelles de la filière Cavendish. Les résultats montrent que le stade de récolte optimal de la nouvelle variété est de 700 degrés.jour calculé avec zéro physiologique de 16,7°C. Fiable et facile d'utilisation, cette technique permet au CIRAD de proposer sur le marché européen un produit répondant aux impératifs propres à la filière d'exportation actuelle. Son intérêt majeur est d'être applicable à toutes nouvelles variétés de fruits climactériques destinés à n'importe quel circuit d'export.
A note on the dynamical features for the extended $f(P)$ cubic gravity
Creators: name: Marciu, Mihai
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The paper studies the physical characteristics for the extended $f(P)$ cubic gravity from a transitive perspective based on dynamical system analysis, by considering the linear stability theory in two specific cases, corresponding to power-law $f(P)=f_0 P^α$ and exponential $f(P)=f_0 e^{αP}$ gravity types, where $f_0$ and $α$ are constant parameters. In these cases we have analyzed the effects in the phase space complexity, revealing the cosmological solutions attached to the critical points. For the power-law and exponential gravity types, we have noticed the presence of two cosmological epochs associated to the critical points involved, corresponding to de-Sitter eras and quintessence-like epochs, described by a constant effective equation of state. For all of these solutions we have studied the dynamical characteristics which are associated to the stability properties, determining possible constraints to various parameters from a transient perspective. The dynamical prospects asserted that the extended $f(P)$ cubic gravity can represent a promising modified theory of gravitation, leading to the manifestation of the accelerated expansion at late time evolution.
BVRI Photometric Observations, Light Curve Solutions and Orbital Period Analysis of BF Pav
Creators: name: Poro, Atila
name: Alicavus, Fahri
name: Fernández-Lajús, Eduardo
name: Davoudi, Fatemeh
name: MirshafieKhozani, PegahSadat
name: Blackford, Mark G.
name: Budding, Edwin
name: Jalalabadi, Behjat Zarei
name: Rahimi, Jabar
name: Farahani, Farzaneh Ahangarani
Publisher: name: arXiv
Year: 2020
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A new ephemeris, period change analysis and light curve modeling of the W UMa-type eclipsing binary BF Pav are presented in this study. Light curves of the system taken in BVRI filters from two observatories in Australia and Argentina were modeled using the Wilson-Devinney code. The results of this analysis demonstrate that BF Pav is a contact binary system with a photometric mass ratio q=1.460+_0.014, a fillout factor f=12.5%, an inclination of 87.97+_0.45 deg and a cold spot on the secondary component. By using the distance modulus formula, the distance of BF Pav was calculated to be d=268+_18 pc which is in good agreement with the Gaia EDR3 distance. We obtain an orbital period increase at a rate of 0.142 s/century due to a quadratic trend in the O-C diagram. Also, an alternative sudden period jump probably has occurred which could be interpreted as a rapid mass transfer from the lower mass star to its companion about DeltaM=2.45*10^(-6) Msun. Furthermore, there is an oscillatory behavior with a period of 18.3+_0.3 yr. Since BF Pav does not seem to have significant magnetic activity, this behavior could be interpreted as the light-time effect caused by an undetected third body in this system. In this case, the probability for the third body to be a low mass star with M>=0.075 Msun or a brown dwarf is 5.4% and 94.6% respectively. If we assume i'=90deg, a_3=8.04+_0.33 AU. The mass of the secondary component was also determined using two different methods which result close to each other.
description: 15 pages, 6 figures, 5 tables, Journal: accepted paper in RAA journal
title: Investigating drug resistance in RAS-driven models of colon cancer
Creators: name: Thakur, Teena
Publisher: name: University of Glasgow
Year: 2025

description: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the world, accounting for more than 900,000 deaths in 2020. A disproportionate number of these deaths are due to KRAS-mutant CRCs, which account for ~40% of all CRC cases and are notoriously resistant to most therapies. Despite showing great promise in preclinical studies, targeted therapies have performed sub-optimally in clinical trials for KRAS mutant cancers. The mechanisms by which RAS pathway inhibitors have failed to reduce tumour progression remains poorly understood and presents a huge clinically unmet need. This research addresses the significant gap in effective treatments for KRAS-mutant CRC by delving into the mechanisms underlying drug resistance, using advanced CRC models. Several studies have reported that drug resistance is an emergent feature of genetically complex tumours.

To capture tumour genome complexity, I used a diverse panel of CRC models reflecting multigenic and heterogeneous nature of tumours. Our patient-specific Drosophila avatars and transgenic mouse models are designed to explore how genome complexity impacts drug response. Our models comprise alterations in at least three primary pathways implicated in CRCs– APC, KRAS and TP53, providing a robust platform for studying the cellular and molecular dynamics driven by oncogenic Ras signalling.

Key findings demonstrate that CRC tumour complexity significantly impacts the efficacy of RAS-pathway inhibitors, which have shown limited success clinically. By characterizing these models, this research has uncovered that different stages of tumour development exhibit varying dependencies on the MAPK pathway, offering insights into the failure of existing therapies. Additionally, the study identifies and validates the upregulation of the glucuronidation detoxification pathway as a novel resistance mechanism, showing that targeted combination therapies can enhance drug efficacy within tumours.

This comprehensive study not only deepens the understanding of CRC pathogenesis and resistance mechanisms but also opens avenues for developing more effective targeted therapies.
Hyperelliptic Curves with Prescribed $p$-Torsion
Creators: name: Glass, Darren
name: Pries, Rachel
Publisher: name: arXiv
Year: 2004
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: In this paper, we show that there exist families of curves (defined over an algebraically closed field $k$ of characteristic $p >2$) whose Jacobians have interesting $p$-torsion. For example, for every $0 \leq f \leq g$, we find the dimension of the locus of hyperelliptic curves of genus $g$ with $p$-rank at most $f$. We also produce families of curves so that the $p$-torsion of the Jacobian of each fibre contains multiple copies of the group scheme $α_p$. The method is to study curves which admit an action by $(\ZZ/2)^n$ so that the quotient is a projective line. As a result, some of these families intersect the hyperelliptic locus $\CH_g$.
description: v2: Strengthened and generalized results, including new results about p-rank. Fixed problems with proofs. Fixed typos
Vadadustat: First Approval
Creators: name: Markham, Anthony
Publisher: name: Adis Journals
Year: 2021
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding.
 Authorship and Conflict of interest A. Markham is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable
Additional information about this Adis Drug Review can be found here

Abstract
Vadadustat (VAFSEO®) is a prolyl hydroxylase inhibitor being developed by Akebia Therapeutics, Inc. (Akebia) for the treatment of anaemia associated with chronic kidney disease (CKD). Akebia is collaborating with Mitsubishi Tanabe Pharma Corporation on the development and commercialization of vadadustat in Japan and with Otsuka Pharmaceutical Co. Ltd on the development and commercialization of vadadustat in the USA, the EU and certain other territories. The drug is approved in Japan for use in adult patients with anaemia associated with CKD and regulatory submissions are planned in the USA and the EU. This article summarizes the milestones in the development of vadadustat leading to this first approval.
© Springer Nature Switzerland AG 2020
Model-based randoms correction for 3D positron emission tomography
Creators: name: Pointoin, Barry William
Publisher: name: University of British Columbia
Year: 2011

description: Random coincidences (randoms) are frequently a major source of image degradation and quantitative inaccuracies in positron emission tomography. Randoms occurring in the true coincidence window are commonly corrected for by subtracting the randoms measured in a delayed coincidence window. This requires additional processing demands on the tomograph and increases the noise in the corrected data. A less noisy randoms estimate may be obtained by measuring individual detector singles rates, but few tomographs have this capability. This work describes a new randoms correction method that uses the singles rates from an analytic calculation, rather than measurements. This is a logical and novel extension of the model-based methods presently used for scatter correction. The singles calculation uses a set of sample points randomly generated within the preliminary reconstructed radioactivity image. The contribution of the activity at each point to the singles rate in every detector is calculated using a single photon detection model, producing an estimate o f the singles distribution. This is scaled to the measured global singles rate and used to calculate the randoms distribution which is subtracted from the measured image data. This method was tested for a MicroPET R4 tomograph. Measured and calculated randoms distributions were compared using count profiles and quantitative figures of merit for a set of phantom and animal studies. Reconstructed images, corrected with measured and calculated randoms, were also analysed. The calculation reproduced the measured randoms rates to within ≤ 1.4% for all realistic studies. The calculated randoms distributions showed excellent agreement with the measured, except that the calculated sinograms were smooth. Images corrected with both methods showed no significant differences due to biases. However, in the situations tested, no significant difference in the noise level o f the reconstructed images was detected due to the low randoms fractions of the acquired data. The model-based method of randoms correction uses only the measured image data and the global singles rate to produce smooth and accurate random distributions and therefore has much lower demands on the tomograph than other techniques. It is also expected to contribute to noise reduction in situations involving high randoms fraction.
MÉTHODES D'ÉVALUATION SIMPLES DES DURÉES DE VIE COMMERCIALE ET DE CONSOMMATION DE NOUVELLES VARIÉTÉS DE BANANE.
SIMPLE METHODS TO EVALUATE THE SALEABLE LIFE AND EDIBLE LIFE OF NEW VARIETIES OF BANANA
Creators: name: Daribo, M. O.
name: Paget, G.
name: Bugaud, C.
name: Daribo, M. O.
name: Paget, G.
name: Bugaud, C.
Publisher: name: Unknown
Year: 2007
Subjects: subject: Crop Production/Industries
subject: Research and Development/Tech Change/Emerging Technologies
subject: banane
subject: durée de vie commerciale
subject: durée de vie de consommation
subject: sensoriel
subject: nouvelle variété

description: Avant de proposer sur le marché de nouvelles variétés de bananes, la durée de vie commerciale et la durée de vie de consommation sont des critères importants qui doivent être connus par les professionnels de la filière. Une méthode simple pour évaluer ces caractéristiques post-récolte a été testée sur 4 nouvelles variétés créées par le CIRAD. La Cavendish (cultivar Grande Naine) a été prise comme témoin. Ces variétés ont été récoltées à un stade permettant leur exportation vers l'Europe. Elles ont été conservées et mûries dans les mêmes conditions. Des analyses physico-chimiques (texture, dégrain, couleur, brix, matière sèche), ainsi que des séances de dégustation ont été réalisés pendant toute la maturité des fruits. Pour déterminer la durée de vie commerciale, les critères les plus pertinents sont une inspection visuelle (couleur peau) et la mesure instrumentale du dégrain. Ce dernier critère permet de déterminer la fin de la durée de vie commerciale. Pour déterminer la durée de vie de consommation et l'optimum de consommation, les critères sensoriels (acceptabilité, sucré, astringence, fermenté et fermeté) ont été plus pertinents que l'analyse physico-chimique. Cette méthode d'évaluation des durées de vie commerciale et de consommation est simple et objective. Elle devrait permettre de prendre en compte ces critères de qualité post-récolte le plus rapidement possible dans le schéma de sélection variétale.
Additional file 4 of CD3+T-lymphocyte infiltration is an independent prognostic factor for advanced nasopharyngeal carcinoma
Creators: name: Al-Rajhi, Nasser
name: Soudy, Hussein
name: Shoaib A. Ahmed
name: Tusneem Elhassan
name: Shamayel F. Mohammed
name: Khoja, Hatim A.
name: Ghebeh, Hazem
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 4: Supplementary Table 1. List of Ventana antibodies used in the study.
THE ROLE OF HUMIC ACIDS FROM CARBONATIC SOILS IN THE SORPTION PROCESS OF AMETRYNE AND DIURON
Creators: name: Dumas, Jose A.
name: Nkedi-Kizza, Peter
name: Zapata, Rafael Montalvo
name: Vega, Jackeline
name: Soler, Sheila
name: Dumas, Jose A.
name: Nkedi-Kizza, Peter
name: Zapata, Rafael Montalvo
name: Vega, Jackeline
name: Soler, Sheila
Publisher: name: Unknown
Year: 2007
Subjects: subject: Land Economics/Use
subject: Humic acids
subject: carbonatic soils
subject: sorption constant

description: Pesticide sorption in soil involves many factors, such as pH, soil redox, the amount and type of humic acids (organic matter), clays and metallic species. Little work in carbonatic soils has been done to study the effect of the above mentioned factors on the sorption of pesticides. Studies were conducted to determine the interaction between these factors and the carbonatic soils. Twelve carbonatic soil series and nine non-carbonatic soil series showed that redox properties for carbonatic soils tended to be smaller and, contrary to the non-carbonatic soils, many of them with negative potentials. We observed a positive correlation between water extractable iron versus diluted acid extractable iron for the carbonatic soils (R2 = 0.88) but not for the non-carbonatic soils. This finding suggests that the reductive environment of carbonatic soils favors the ferrous species (Fe+2) rather than the ferric (Fe+3). These factors apparently affect the solubility of the organic matter, thus decreasing the sorption of pesticides in carbonatic soils compared to that of non-carbonatic. We observed a positive correlation between the extinction coefficients (k) at 280 nm for the humic acids of carbonatic soils and the sorption coefficients of atrazine and diuron (R2 = 0.61 and 0.56, respectively). The k values at 300 nm did not show a significant correlation. The averaged pKa values for humic acids from the soils in this study were similar. However, the first derivative titration plots of humic acids showed that humic acids from soils in this study contained several kinds of functional groups with different pKa values, and also suggest that the properties of the functional groups are different. The data suggest that the aromatic rather than the aliphatic content of humic acids seems to have a predominant role in the soil sorption of pesticides. These findings indicate the importance of studying more in depth the sorption, mobility and degradation of pesticides in carbonatic soils in order to protect the water resources.
The Einstein-Vlasov system with a scalar field
Creators: name: Lee, Hayoung
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the Einstein-Vlasov system coupled to a nonlinear scalar field with a nonnegative potential in locally spatially homogeneous spacetime, as an expanding cosmological model. It is shown that solutions of this system exist globally in time. When the potential of the scalar field is of an exponential form, the cosmological model corresponds to accelerated expansion. The Einstein-Vlasov system coupled to a nonlinear scalar field whose potential is of an exponential form shows the causal geodesic completeness of the spacetime towards the future. The asymptotic behaviour of solutions of this system in the future time is analysed in various aspects, which shows power-law expansion.
description: 30 pages
TILLAGE RESIDUAL EFFECTS ON A CROP ROTATION OF TARO, CABBAGE AND EGGPLANT IN OXISOL, ULTISOL AND VERTISOL SOILS IN PUERTO RICO
Creators: name: Lugo, Wanda I.
name: Gonzalez, Agenol
name: Roman, Felix
name: Roman, Elvin
name: Lugo, Wanda I.
name: Gonzalez, Agenol
name: Roman, Felix
name: Roman, Elvin
Publisher: name: Unknown
Year: 2007
Subjects: subject: Crop Production/Industries
subject: Land Economics/Use
subject: Tillage
subject: crop rotation
subject: conservation tillage
subject: tropical soils

description: An experiment was established to evaluate several tillage treatments and their residual effect on a crop rotation that included taro, cabbage and eggplant. The experiment was established at three ecologically different locations with three different soil series and orders. At two locations (Ultisol and Vertisol soils), the treatments were conventional tillage; conventional tillage - no beds; deep till + conventional tillage; and deep till. At the third location (Oxisol soil) the treatments were no-till; conventional tillage; deep till + conventional tillage; and deep till. Taro was planted after soil preparation according to the treatments. The crops that followed in the rotation were planted no-till in the same plots. A fifth treatment, in which all crops in the rotation were planted under conventional tillage, was used as a check. In the Oxisol soil, taro yields in the no-till plots were significantly lower than yields in any of the other treatments. There were no yield differences among the other treatments. In the Ultisol soil, the higher taro yields were obtained in plots where no beds were raised (deep till and conventional - no beds); whereas in the Vertisol soil the lowest yields were obtained in the deep tilled plots. Yields of cabbage and eggplant were not significantly different among treatments in the Oxisol and Ultisol soils. In the Vertisol soil, cabbage yields were significantly higher in plots with the continuous conventional tillage. The results suggest a positive residual effect from the tillage operations performed prior to planting the taro crop in the Ultisol. The good physical properties of the Oxisol soil probably contributed to the lack of differences in cabbage and eggplant yields.
Khorata Huber 2005
Creators: name: Tong, Yanfeng
name: Li, Shuqiang
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Pholcidae
Khorata

description: Khorata Huber, 2005
 Khorata Huber, 2005b: 79–83. Type species: K. khammouan Huber, 2005.
description: Published as part of Tong, Yanfeng & Li, Shuqiang, 2008, Four New Species Of Six-Eyed Pholcid Spiders (Araneae: Pholcidae) From Hainan Island, China, pp. 45-53 in Raffles Bulletin of Zoology 56 (1) on page 52, DOI: 10.5281/zenodo.4509100