cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-pdf-17-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis
Creators: name: Hegen, Harald
name: Walde, Janette
name: Berek, Klaus
name: Arrambide, Georgina
name: Gnanapavan, Sharmilee
name: Kaplan, Batia
name: Khalil, Michael
name: Saadeh, Ruba
name: Teunissen, Charlotte
name: Tumani, Hayrettin
name: Villar, Luisa M
name: Willrich, Maria Alice V
name: Zetterberg, Henrik
name: Deisenhammer, Florian
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Aged Health Care

description: Supplemental material, sj-pdf-17-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal
The ballistic performance of thick ultra high molecular weight polyethylene composite
Creators: name: Nguyen, Long
Publisher: name: RMIT University
Year: 2024

description: Ultra-high molecular weight polyethylene (UHMW-PE) fibre-reinforced composite is a promising material for ballistic protection due to its high strength, stiffness and low density. For thick sections of this material however, there is limited understanding of the mechanisms driving ballistic performance. Existing analysis tools do not allow for a good approximation of performance, while existing numerical models are either incapable of accurately capturing the response of thick UHMW-PE composite to ballistic impact or are unsuited to model thick targets.

In this thesis, the response of thick UHMW-PE composite to ballistic impact was experimentally investigated. Panel thicknesses ranging from 9 mm to 100 mm impacted by 12.7 mm and 20 mm calibre fragment simulating projectiles (FSPs) were investigated. The penetration and failure mechanisms were identified by inspection of impacted targets, and scanning electron microscopy was conducted to inspect the load-bearing fibres around the penetration cavity. Thick targets demonstrated a two-stage penetration process: shear plugging during the initial penetration followed by the formation of a transition plane and bulging of a separated rear panel.

A new analytical model was developed for thick UHMW-PE composite impacted by blunt projectiles to describe the two stages of penetration identified in the experimental work. The analytical model is based on energy and momentum conservation laws, and uses an energy balance between the projectile kinetic energy and the energy absorbed by the target to predict the ballistic limit velocity. The model was validated against experimental ballistic limit results and showed excellent agreement for thick targets. Existing analytical models based on membrane theory were validated against results of thinner targets and demonstrated to be more suitable.

A numerical modelling methodology was developed for the ballistic impact analysis of thick UHMW-PE composite using a commercial hydrocode. A novel approach was used to model interlaminar failure by dividing the panel into sub-laminates connected by breakable bonds. A new failure-based element erosion model was implemented with a user subroutine, which more accurately accounts for the directional properties of fibre-reinforced composites than existing strain-based models. The model is extensively validated against experimental ballistic data. The model gave excellent predictions for depth of penetration, residual velocity and ballistic limit, with results within 5% of experiment for all conditions considered (12.7 mm and 20 mm FSP, 9 mm to 100 mm thick targets and impact velocities between 400 m/s to 2000 m/s). The predictions of the penetration mechanisms and target bulge behaviour were also compared in terms of the target shear plugging ratio and bulge hinge and apex position, also demonstrating very good correlation with the experimental results.
Managing multi-purpose leisure facilities in a time of climate change
Creators: name: K McDonald
name: Stewart, Bob
name: Dingle, Gregory
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: In this paper, we examine the ways in which multi-purpose leisure facilities (MPLFs) - being pivotal places for delivering aquatic, exercise, and indoor sport programmes - have responded to the climate change problem. The study was framed by a resource-based view of organisations which theorises that the capacity for effective responses will be dependent upon the breadth and quality of the resources available for strategy formulation and implementation. Using an intensive case study methodology, two distinct MPLFs in Melbourne, Australia, were targeted for the analysis. It was found that while the managers of each facility were aware of the climate change problem, the preparedness to initiate change in response to shifting weather patterns - either through mitigation or adaptation - was more pronounced for the facility that had a strong base of 'environmental knowledge resources'. Additionally, these resources were used to pursue mainly adaptation strategies that included more efficient electric power use and frugal water use. © 2014 Taylor & Francis.
Additional file 3: Table S3. of A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer
Creators: name: Reynolds, Kerry
name: Bedard, Philippe
name: Se-Hoon Lee
name: Lin, Chia-Chi
name: Tabernero, Josep
name: Alsina, Maria
name: Cohen, Ezra
name: JosĂŠ Baselga
name: Blumenschein, George
name: Graham, Donna
name: Garrido-Laguna, Ignacio
name: Juric, Dejan
name: Sharma, Sunil
name: Salgia, Ravi
name: Abdelkader Seroutou
name: Xianbin Tian
name: Fernandez, Rose
name: Morozov, Alex
name: Sheng, Qing
name: Thiruvamoor Ramkumar
name: Zubel, Angela
name: Yung-Jue Bang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Adverse events (all grades [â Ľ5%]) requiring dose adjustment/interruption, regardless of causality, by treatment group. Footnote: Q2W once every two weeks, QW once weekly, RDE recommended dose for expansion. (DOCX 15 kb)
Triton X-114 phase separation in the isolation and purification of mouse liver microsomal membrane proteins
Creators: name: Mathias, RA
name: Chen, YS
name: Kapp, EA
name: Greening, David
name: Mathivanan, Suresh
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Integral membrane proteins (IMPs) mediate several cellular functions including cell adhesion, ion and nutrient transport, and cell signalling. IMPs are typically hard to isolate and purify due to their hydrophobic nature and low cellular abundance, however, microsomes are small lipid vesicles rich in IMPs, which form spontaneously when cells are mechanically disrupted. In this study, we have employed mouse liver microsomes as a model for optimising a method for IMP isolation and characterisation. Microsomes were collected by differential centrifugation, purified with sodium carbonate, and subjected to GeLC-MS/MS analysis. A total of 1124 proteins were identified in the microsome fraction, with 47% (524/1124) predicted by TMHMM to contain at least one transmembrane domain (TMD). The ability of phase partitioning using the detergent Triton X-114 (TX-114) to further enrich for membrane proteins was evaluated. Microsomes were subjected to successive rounds of solubility-based phase separation, with proteins partitioning into the aqueous phase, detergent phase, or TX-114-insoluble pellet fraction. GeLC-MS/MS analysis of the three TX-114 fractions identified 1212 proteins, of which 146 were not detected in the un-fractionated microsome sample. Conspicuously, IMPs partitioned to the detergent phase, with 56% (435/770) of proteins identified in that fraction containing at least one TMD. GO Slim characterisation of the microsome proteome revealed enrichment of proteins from the endoplasmic reticulum, mitochondria, Golgi apparatus, endosome, and cytoplasm. Further, enzymes including monooxygenases were well represented with 35 cytochrome P450 identifications (CYPs 1A2, 2A5, 2A12, 2B10, 2C29, 2C37, 2C39, 2C44, 2C50, 2C54. 2C67, 2C68, 2C70, 2D10, 2D11, 2D22, 2D26, 2D9, 2E1, 2F2, 2J5, 2U1, 3A11, 3A13, 3A25, 4A10, 4A12A, 4A12B, 4F13, 4F14, 4F15, 4V3, 51,7B1, and 8B1). Evaluation of biological processes showed enrichment of proteins involved in fatty acid biosynthesis and elongation, as well as steroid synthesis. In addition, transport proteins including 24 members of the Rab family of GTPases were identified. Comparison of this dataset with the current mouse liver microsome proteome contributes an additional 648 protein identifications, of which 50% (326/648) contain at least one TMD. © 2011 Elsevier Inc.
Comparison of human platelet membrane-cytoskeletal proteins with the plasma proteome: Towards understanding the platelet-plasma nexus
Creators: name: Greening, David
name: Glenister, KM
name: Kapp, EA
name: Moritz, RL
name: Sparrow, RL
name: Lynch, GW
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Platelets are essential for maintaining vascular integrity. Given the anucleate nature of platelets, definition of their proteome is essential for understanding platelet pathophysiology. We describe here a detailed MS-based proteomic analysis of the platelet membrane/cytoskeletal sub-proteome from purified, normal, non-activated human platelets. In contrast to previous platelet proteomic purification strategies, the buffy-coat method was utilized in this study to isolate and purify minimally activated platelets, yielding significantly reduced contaminants for leukocytes (0.02 ± 0.007 × 106/ L) and erythrocytes (0.21 ± 0.02%). Using a false discovery rate of 1%, 203 proteins were identified and characterized with respect to their subcellular localization, biological function, and cellular processes. Of these, 16 have not been identified in previous human platelet proteome studies. As a first approach towards understanding the dynamic platelet-plasma protein composition nexus, we re-analysed the entire HUPO plasma proteome project dataset (647 plasma proteins identified) and compared these data with our platelet proteome dataset. Co-identified proteins (41) were further analysed with respect to their relative abundances (exponentially modified protein abundance index) and functional enrichment in these two proteomes, as well as their correlation with the platelet transcriptome. Both platelet membrane/ cytoskeletal and plasma proteome reference datasets, comprising both processed and unprocessed MS/MS spectra, are publicly accessible (http://www.ludwig.edu.au/archive/). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Proteomics-driven cancer biomarker discovery: looking to the future
Creators: name: Simpson, Richard
name: Bernhard, OK
name: Greening, David
name: Moritz, RL
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Availability of a suite of biomarkers for early detection, stratification into distinct subtypes, and monitoring progression or response to therapy promises significant improvements in clinical outcomes for cancer patients. However, despite the recent progress in proteomics technologies based on mass spectrometry (MS), discovery of novel clinical assessment tools has been slow. This is, partly due to the inherent difficulties in working with blood as the biospecimen for candidate discovery. A better understanding of the limitations of blood for comparative protein profiling and a better appreciation of the advantages of cancer tissue or cancer cell secretomes have the potential to greatly enhance the progress. Crown Copyright © 2008.
A Novel Design Technique of Hypersonic Gliding Vehicle
Creators: name: ZHANG, Tian-Tian
name: HUANG, Wei
name: LI, Shi-Bin
name: WANG, Zhen-Guo
Publisher: name: Proceedings of the 7th European Conference for Aeronautics and Space Sciences. Milano, Italy, 3-6 july 2017
Year: 2017
Subjects: AIRCRAFT
AERODYNAMICS
DESIGN
NUMERICAL SIMULATION
HYPERSONICS

description: Hypersonic gliding vehicle is attracting an increasing attention because of its high lift-to-drag ratio and high cruising speed. Based on the design theory of cone-derived waverider, this paper proposes a novel design approach of hypersonic gliding vehicle, which is accommodated in a wide speed range. The parametric method employed in ascender line makes it possible to control the overall configuration. Numerical analysis demonstrates that this kind of aircrafts own good wave-ride properties in the designed speed range. The simplified trajectory performance analysis shows a wavy trajectory with long range, which makes it suitable for long-distance transportation and tactical defense penetration.
Additional file 4 of Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy
Creators: name: Ortiz, Camila
name: Pearson, Andrew
name: McCartan, Robyn
name: Roche, Shawn
name: Carothers, Nolan
name: Browning, Mackenzie
name: Perez, Sylvia
name: He, Bin
name: Ginsberg, Stephen D.
name: Mullan, Michael
name: Mufson, Elliott J.
name: Crawford, Fiona
name: Ojo, Joseph
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Supplementary Material 4: Table 1. Antibodies used. Abbreviations: GFAP, Glial Fibrillary Acidic Protein; Iba1, Ionized calcium-binding adaptor molecule; AQP4, aquaporin 4; GLAST, Glutamate transporter; GLT1, Glutamate transporter 1. IF, Immunofluorescence; IHC, Immunohistochemistry; WB, Western blotting.
Techniques for the design of a low noise, high dynamic range, high gain, wideband amplifier for analogue OEIC applications
Creators: name: Taher, Shuchin
Publisher: name: RMIT University
Year: 2024

description: Various techniques for the Design of a Low Noise, High Dynamic Range, High Gain, Wideband Amplifier for Analogue OEIC Applications, such as radar receiver arrays for electronic warfare applications were developed and investigated in this work.

Firstly, the available transistor technologies, semiconductor technologies and photodetector technologies and their pros and cons in light of the target application type are investigated in order to decide on the technologies best suited for this research, and justification of the chosen options are presented.

Secondly, three different known amplifier topologies are discussed and their linearity, gain, bandwidth, SFDR, and other performances are compared via simulations calibrated against measured results. The results from the comparisons are analysed and the amplifier topology most suitable for this work is chosen based on these results.

Thirdly, three different circuit alteration techniques for improving the linearity and SFDR of the previously chosen amplifier topology are developed, analysed and verified through simulations. It is shown that these techniques can be combined to gain further improvement in overall performance.

And finally, the influence of various geometrical and doping alterations of the transistor on desired figures of merit, i.e. gain, bandwidth, linearity, etc. are investigated in detail using two-dimensional physical device simulations calibrated against measured results of an InP/InGaAs single heterojunction bipolar transistor. The device simulations were carried out using Technology-Computer-Aided-Design (TCAD) within the SILVACO software package. The results are then used to suggest techniques to improve performance at the transistor level.
Numerical Research of A Propeller Plane Based on Actuator Disc Model
Creators: name: ZHANG, Yifei
name: CHEN, Haixin
name: ZHANG, Yufei
Publisher: name: Proceedings of the 7th European Conference for Aeronautics and Space Sciences. Milano, Italy, 3-6 july 2017
Year: 2017
Subjects: AERODYNAMICS
AEROSPACE PROPULSION
AIRCRAFT PROPULSION
CFD
NUMERICAL SIMULATION

description: The flow of a propeller is complex and has obvious influence on the aircraft. Though computer is becoming powerful, numerical simulation on propeller slipstream is still difficult. When doing optimization, actuator disc model could be used to save computation costs and computation time. This paper studies a propeller, then use the actuator disc model to study the slipstream of a propeller plane.
Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells
Creators: name: Ji, H
name: Greening, David
name: Kapp, EA
name: Moritz, RL
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Although experiments in rodents and human population-based studies have demonstrated the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac in colorectal cancer (CRC) prevention, a detailed knowledge of the underlying mechanism of action of this drug is limited. To better understand the chemopreventitive effects of sulindac, especially early sulindac-induced apoptotic events, we used the CRC cell line LIM1215 as an experimental model, focusing on proteins secreted into the LIM1215 culture medium-i.e., the secretome. This subproteome comprises both soluble-secreted proteins and exosomes (30-100 nm diameter membrane vesicles released by several cell types). Selected secretome proteins whose expression levels were dysregulated by 1 mM sulindac treatment over 16 h were analyzed using 2-D DIGE, cytokine array, Western blotting, and MS. Overall, 150 secreted proteins were identified, many of which are implicated in molecular and cellular functions such as cell proliferation, differentiation, adhesion, invasion, angiogenesis, metastasis, and apoptosis. Our secretome-based proteomic studies have identified several secreted modulators of sulindac-induced apoptosis action (e.g., Mac-2 binding protein, Alix, 14-3-3 isoforms, profilin-1, calumenin/Cab45 precursors, and the angiogenic/tumor growth factors interleukin 8 (IL-8) and growth related oncogene (GRO-α)) that are likely to improve our understanding of the chemopreventitive action of this NSAID in CRC. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Relationship between depression, quality of life and foot ulcer healing rates in type 2 diabetic (T2D) patients
Creators: name: Steel, Andrew
Publisher: name: RMIT University
Year: 2024
Subjects: classificationCode: 529999
subject: Other psychology not elsewhere classified

description: Type 2 diabetes (T2D) prevalence is increasing, not only in Australia, but also worldwide. Often referred to as the `lifestyle disease of the 21st century', the impact it has on individuals can be profound. A significant co-morbidity and the most common complication of T2D is foot ulcers. There is an established relationship between depression and T2D; however, no studies have investigated this relationship amongst a population with a diabetic foot ulcer (DFU). This study's aim was to investigate the relationship between different levels of depressive symptoms, Quality of Life (QoL), and healing time of people with T2D and a DFU. The relationship between different levels of T2D on healing time of foot ulcers and QoL was also explored. The study's
sample was drawn from a High Risk Foot Service (HRFS) at Northern Health, Victoria, Australia. All participants had T2D and a neuropathic foot ulcer. The sample participants; 59 males and 22 females, with a mean age of 62.6 years (SD = 12.2, range of 21 years to 85 years), were assessed for their level of depressive symptoms using the Center for Epidemiologic Studies Depression scale and their QoL using the World Health Organisation Quality of Life BREF scale. Significant relationships were found between different levels of depressive symptoms, healing time and QoL. Higher levels of depressive symptoms correlated with longer healing time. T2D levels had no significant relationship with healing time or QoL; however, T2D levels mediated the direct relationship between depressive symptoms and healing time. Healing time was found to be inversely related to all measures of QoL. The clinical significance of these results is relevant, in providing insight into the relationship that depressive symptoms and QoL have with the healing time of diabetic foot ulcers. These results also suggest that treatment approaches incorporating the treatment of depression and improving QoL.
2D Thermo-Structural Code Development for Regenerative Combustion Chamber Analysis
Creators: name: TERRACCIANO, Andrea
name: LIUZZI, Daniele
name: PASCUCCI, Alessandro
Publisher: name: Proceedings of the 7th European Conference for Aeronautics and Space Sciences. Milano, Italy, 3-6 july 2017
Year: 2017
Subjects: CRYOGENIC PROPULSION
AEROSPACE PROPULSION
STRUCTURES

description: In the frame of research activities, AVIO S.p.A. is striving for high effort to design regenerative cooled combustion chamber for the new cryogenic engines development for Vega-E application. The dimensioning of a regenerative cooled combustion chamber depends on the coupling between the performance of the cooling system and its structural resistance. To optimize the geometry of combustion chamber liner and reduce the design time, a suitable tool is needed to estimate the distribution of temperatures within the wall and the thermo-mechanical stresses that act on the structure. This objective can be achieved by means of a 3D FEM commercial tool, but a lot of time is needed to perform the geometry by CAD and to set the mesh, boundary condition and execution. Moreover, the process is not automatic, so it is not suitable for an optimization activity of the combustion chamber. To face the challenges of the scope, AVIO S.p.A. developed a 2D tool. The steady state non-linear thermo-structural code is based on finite element method and it is able to analyze typical 2D combustion chamber cross sections and to estimate the temperature field as well as the stress field within the structures. The implementation of input, together with the execution of the code and getting results, require less than 2 orders of magnitude with respect to 3D FEM commercial tool analysis. So, the process is suitable for designing optimization activities, being able to drastically decrease the design time with respect to that required by a 3D FEM commercial tool. The definition of a first geometry of the most representative chamber cross sections, already optimized by the thermo - structural point of view and with respect to number of life cycles required, will be already accomplished. In this way, the 3D - FEM analysis will require 1 or 2 loop as maximum (instead of 5-6 loops required by an optimization activities of the geometry), to analyze only the combustion chamber interfaces.
title: Gewalt im Musikfernsehen und ihre gesellschaftlichen Auswirkungen
Creators: name: Jachs, Philipp
Year: 2010

description: In dieser Arbeit wird das Thema „Gewalt im Musikfernsehen und ihre gesellschaftlichen Auswirkungen“ untersucht. Sowohl der theoretische, als auch der empirische Teil beschäftigt sich mit diesem Thema quer durch die Fächer der Kommunikationswissenschaft, Psychologie, Soziologie, Musikwissenschaft und Pädagogik. Wichtige theoretische Eckpfeiler sind vor allem die Cultural Studies, diverse Medienwirkungstheorien in Bezug auf Gewalt und Theorien zu dem Thema „Unterhaltung“. Weiters wird der Begriff Gewalt erforscht und definiert, wie er mit Jugendströmungen zusammenhängt. Das Hauptaugenmerk liegt vor allem auf dem empirischen Teil, so beinhaltet dieser drei unterschiedliche Untersuchungen: eine quantitative Befragung, eine qualitative Onlinebefragung und zu guter letzt ein Experteninterview.
Enrichment of human platelet membranes for proteomic analysis
Creators: name: Greening, David
name: Glenister, Kristen M.
name: L. Sparrow, Rosemary
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: This protocol details the extraction and purification of platelet membrane proteins from whole blood using SDS-PAGE in conjunction with LC-MS/MS. This method allowed the identification, and characterization of 207 platelet membrane proteins (PMP) from approximately 9.95 x 10(9) platelets (16).
Nanocarriers-encapsulating phytochemicals as potent therapeutics in cancer therapy
Creators: name: Radhakrishnan, Rasika
Publisher: name: RMIT University
Year: 2024
Subjects: classificationCode: 310102
subject: Cell development, proliferation and death
classificationCode: 310607
subject: Nanobiotechnology
classificationCode: 401807
subject: Nanomaterials

description: Cancer is a disease concerning the abnormal, uncontrolled growth of cells that possess a potential to invade and injure other parts of the body. Chemotherapy involves administration of drugs targeted towards the mechanisms responsible for this rapid division and proliferation. However, most chemotherapy drugs are non-specific, also causing allied toxicity to normal cells undergoing cell division.

In this work, phytochemicals were used as anti-cancer drugs. These molecules are non-toxic and biocompatible. However, they also display striking anti-cancer potential, which was explored in this thesis. In this work, epigallocatechin gallate, piperine and mangiferin have been explored for their anti-cancer efficacy.

Although phytochemicals are effective agents in cancer chemotherapy, many of them suffer from disadvantages such as pH instability and limited bioavailability in the body. To address this problem, nanocarriers were designed to facilitate their increased bioavailability and stability inside the body. Two nanoparticle matrices were explored in this work; solid lipid nanoparticles and chitosan nanoparticles. Solid lipid nanoparticles were used as they are biocompatible, help improve drug stability and show controlled release. Chitosan nanoparticles are biodegradable, biocompatible and have shown excellent absorption properties for chemotherapeutic drugs.

Chemotherapy mainly deals with two targeting approaches; active and passive. While passive targeting relies on the characteristics of the tumour for effective therapy, active targeting involves attachment of ligands on the nanocarrier for more specific targeting. Both the targeting approaches have been explored in this work. In addition, two targeting ligands were used in this work; bombesin and mannose, which are specific for factors overexpressed in cancer.

In summary, this thesis involves the design and fabrication of nanocarriers in order to increase the anti-cancer efficacy of phytochemicals, utilising different targeting approaches, matrix components and targeting ligands. The anti-cancer efficacy was evaluated by in-vitro cytotoxicity studies and in-vivo animal studies. The results validate the increased anti-cancer efficacy provided by the encapsulation of the drugs within nanocarrier systems thus offering encouraging, novel possibilities in the field of cancer therapy.
International blood collection and storage: Clinical use of blood products
Creators: name: Greening, David
name: Glenister, KM
name: Sparrow, RL
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Human blood transfusion is the process of transferring blood or blood-based products from an individual into the circulatory system of another. From the theory of circulation of blood to the early practice of blood transfusion, transfusion medicine has been an important concept for many centuries. The practicality of transfusion, however, only became a possibility during and shortly after the Second World War. Today, blood and its derivatives play a critical role in worldwide health care systems, with blood components having direct clinical indications. Over the past several years worldwide organizations including the World Health Organization (WHO) have made a number of substantial improvements to the regulation of the worlds blood supply. This continuous supply plays a critical role throughout health care systems worldwide, with procedures for blood collection, processing, and storage now complex, standardised processes. As the areas of clinical validation of different disease states from blood-derived sources (i.e., disease biomarkers) move towards validation stages, the importance of controlled- and standardised-protocols is imperative. Crown Copyright © 2009.
Kompetenzen für Arbeit in Netzwerken an Öffentlichen Bibliotheken
Creators: name: Umlauf, Konrad
Publisher: name: Humboldt-Universität zu Berlin
Year: 2001
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Der Beitrag umreißt den Wandel, dem Öffentliche Bibliotheken seit den 90er Jahren auf dem Hintergrund von Internet, Verwaltungsreform, Entstehung der Wissensgesellschaft und Haushaltskrisen unterliegen, legt dann die Kompetenzanforderungen an das Bibliothekspersonal dar, die sich daraus ergeben. Der Fokus liegt auf den Aspekten der Kompetenzen, die erfolgreiches Arbeiten in Netzwerken für Management- und Führungsqualifikationen, für Entwicklungskompetenz, soziales und gesellschaftsbezogenes Handeln, für fachlich-methodisches Wissen benötigt. Schließlich wird untersucht, wieweit Aus- und Fortbildung des Bibliothekspersonals diese Anforderungen berücksichtigen. Der Beitrag kommt zu dem Ergebnis, dass das Personal an Öffentlichen Bibliotheken über neue Kompetenzen für netzwerkorientierte Arbeitsumgebungen teils bereits verfügt, teils exzellente Bedingungen vorfindet, diese Kompetenzen zu erwerben, und insgesamt ein ausgeprägtes Bewusstsein davon hat, dass es sich neuen Anforderungen stellen muss. Es mangelt jedoch oft an systematischer Personalentwicklung; Fortbildung ist noch zu oft auf punktuelle Initiativen und persönliche Tatkraft gegründet.
Additional file 1 of “I do not know the advantages of having a general practitioner” - a qualitative study exploring the views of low-acuity emergency patients without a regular general practitioner toward primary care
Creators: name: Kümpel, Lisa
name: Oslislo, Sarah
name: Resendiz Cantu, Rebecca
name: Möckel, Martin
name: Heintze, Christoph
name: Holzinger, Felix
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Die Anhaltische Landesbücherei Dessau und ihr Angebot
Creators: name: Schade, Katrin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2003
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Die Durchführung einer Benutzerbefragung in der Anhaltischen Landesbücherei Dessau bildet die Grundlage zur Ermittlung der Benutzerstruktur, des Benutzerverhaltens und der Benutzerzufriedenheit mit den Angeboten und Leistungen der Bibliothek. Ausgehend von der Vorstellung des Bibliotheknetzes und der Beschreibung bibliotheksrelevanter Faktoren erfolgt die Auswertung, der im Juni 2002 vorgenommenen Befragung. In einer abschließenden Betrachtung werden die gewonnenen Erkenntnisse zusammengefasst und Anregungen für die künftige Bibliotheksarbeit gegeben.
sj-pdf-1-jcb-10.1177_0271678X221142533 - Supplemental material for Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen
Creators: name: Katz, Brittany M
name: Walton, Lindsay R
name: Houston, Kaiulani M
name: Cerri, Domenic H
name: Shih, Yen-Yu Ian
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221142533 for Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen by Brittany M Katz, Lindsay R Walton, Kaiulani M Houston, Domenic H Cerri and Yen-Yu Ian Shih in Journal of Cerebral Blood Flow & Metabolism
Evaluation of the Grid Convergence for a Rocket Combustion Chamber with a Porous Injector
Creators: name: ZHUKOV, Victor
name: HEINRICH, Klaus
Publisher: name: Proceedings of the 7th European Conference for Aeronautics and Space Sciences. Milano, Italy, 3-6 july 2017
Year: 2017
Subjects: CFD
COMBUSTION CHAMBERS
REACTIVE FLOW
NUMERICAL SIMULATION
TURBULENT COMBUSTION

description: The purpose of the present study is to quantify the grid convergence in simulations of rocket combustion chambers performed with the averaged Navier-Stokes equations. The present work is a continuation of the previous studies on simulations of rocket combustion chambers with porous injector head API-68. Turbulence is modelled by the SST turbulence model; turbulent combustion is modelled using the extended eddy-dissipation model developed earlier. The grid convergence study is carried out for two injector configurations on five meshes for each configuration. Results shows that the dependences of the flame length and wall heat flux on mesh spacing is described well by a parabola, and the modelling using the current model requires a spacing of around 30 m.
title: Corporate Social Responsibility - Analyse der Auswirkungen von CSR-Maßnahmen durch die PR-Arbeit
Creators: name: Schmidt, Sarah Edith
Year: 2010

description: Die vorliegende Magisterarbeit machte es sich zur Aufgabe, das Managementkonzept der Corporate Social Responsibility zu beleuchten und zu ergründen, ob die im Rahmen des Konzeptes an den Tag gelegte gesellschaftliche Verantwortung von Wirtschaftsunternehmen Auswirkungen auf den Kunden hat. So wurde zuerst eine theoretische Grundlage gebildet, um CSR zu betrachten, zu definieren und in Zusammenhang zu bringen. Im Zuge dieser Forschungsarbeit erfolgte dann eine Annäherung an das Erkenntnisinteresse durch qualitative Experteninterviews mit 15 Experten, am Fallbeispiel H&M. Die inhaltliche Aufbereitung dieser Interviews ergab als zentrales Ergebnis, dass eine aktive Wahrnehmung von gesellschaftlichem Engagement von Unternehmen nur auf aktive Kommunikation darüber erfolgt, sowie, dass damit auch eine Beeinflussung der Kaufentscheidung einhergehen kann. Wird dies auf diese Weise gehandhabt, dann gibt es tatsächlich eine Steigerung der Wahrnehmung, des Ansehens und ggfs. der positiven Kaufentscheidung.
description: The aim of this master thesis was to explore the management concept of Corporate Social Responsibility and find out whether the social responsibilities of businesses have significant effects on the reputation and the image towards the business by the customer. Therefore, the concept of Corporate Social Responsibility was theoretically analyzed. It was the objective of this research paper to investigate by using qualitative research. 15 experts were interviewed and a content analysis of the material showed the result that social responsibility of businesses is positively connoted by the customers, if it is actively communicated to them. Additionally, it can also influence the purchase decision positively.
A centrifugal ultrafiltration strategy for isolating the low-molecular weight (≤ 25 K) component of human plasma proteome
Creators: name: Greening, David
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The low-molecular weight fraction (LMF) of the human plasma proteome is an invaluable source of biological information, especially in the context of identifying plasma-based biomarkers of disease. In this study, a separation and enrichment strategy based on centrifugal ultrafiltration was developed for the LMF (i.e., ≤ 25 K) of plasma routinely prepared from normal, healthy volunteers. Four commercially-available filter membranes of similar nominal molecular weight cut-off (NMWC), but differing membrane chemistries and filter orientations (Microcon®, Millipore; Centrisart®, Sartorius; Amicon Ultra®, Millipore; Vivaspin®, Sartorius), were evaluated. Of these filtration devices, only the Sartorius Vivaspin® tangential membrane, NMWC 20 K was effective in the non-retention of Mr > 50 K, and recovery and enrichment of low-Mr components from human plasma. This filter membrane device was further optimized with respect to plasma buffer composition, centrifugal force, duration and temperature. Optimal ultrafiltration conditions were obtained using 100 μL of normal plasma in 10% acetonitrile, and a centrifugation force of 4000 × g for 35 min at 20 °C. In this LMF, 44 proteins (from 266 unique peptides) were identified using a combination of 1D-SDS-PAGE / nano-LC-MS/MS and a stringent level of identification (FDR < 1%). We report the identification of several proteins (e.g., protein KIAA0649 (Q9Y4D3), rheumatoid factor D5, serine protease inhibitor A3, and transmembrane adapter protein PAG) previously not reported in extant high-confidence Human Proteome Organization (HUPO) Plasma Proteome Project datasets. When compared with the low-Mr human plasma/serum proteome datasets of Zhou et al. (Electrophoresis, 2004. 25, 1289-98), Gundry et al. (Proteomics Clin. Appl., 2007. 1, 73-88) and Villanueva et al. (Anal Chem, 2004. 76, 1560-70), 64% of our identifications (28 proteins) were novel; these include cofilin-1, PPIase A, and the SH3 domain-binding glutamic acid-rich-like protein 3. In addition to intact proteins, many peptide fragments from high-abundance proteins (e.g., fibrinogen, clusterin, Factor XIIIa, transferrin, kinogen-1, and inter-alpha-trypsin inhibitor), presumably derived by ex vivo proteolysis, were observed. © 2009 Elsevier B.V. All rights reserved.
Pressure gradient effects on wake flow instabilities behind isolated roughness elements on re-entry capsules
Creators: name: THEISS, Alexander
name: LEYH, Sascha
name: HEIN, Stefan
Publisher: name: Proceedings of the 7th European Conference for Aeronautics and Space Sciences. Milano, Italy, 3-6 july 2017
Year: 2017
Subjects: BOUNDARY LAYERS
INSTABILITY
FLUID MECHANICS
HYPERSONICS

description: Laminar-turbulent transition caused by modal disturbance growth in the wake flow of isolated roughness elements on blunt re-entry capsules is studied numerically at typical cold hypersonic wind tunnel conditions. Two fundamentally different heat shield shapes are considered. On the sphere-cone forebody the wake flow of the roughness is exposed to an adverse pressure gradient, whereas the spherical heat shield exhibits a strongly favourable pressure gradient. The pressure gradient effects on the development of the stationary wake flow and its modal instability characteristics are discussed for various heights and diameters of the cylindrical roughness element. Regions of increased shear develop in its wake which persist longer in the adverse pressure gradient case. Consequently, the results of spatial two-dimensional eigenvalue analyses reveal that the unstable wake flow region extends much further downstream and the wake mode instabilities are considerably more amplified. The disturbance kinetic energy production terms are used to assess the contributions of the different shear-layer regions to the mode growth and its dependence on the pressure gradient.
Low-molecular weight plasma proteome analysis using centrifugal ultrafiltration
Creators: name: Greening, David
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The low-molecular weight fraction (LMF) of the human plasma proteome is an invaluable source of biological information, especially in the context of identifying plasma-based biomarkers of disease. This protocol outlines a standardized procedure for the rapid/reproducible LMF profiling of human plasma samples using centrifugal ultrafiltration fractionation, followed by 1D-SDS-PAGE separation and nano-LC-MS/MS. Ultrafiltration is a convective process that uses anisotropic semipermeable membranes to separate macromolecular species on the basis of size. We have optimized centrifugal ultrafiltration for plasma fractionation with respect to buffer and solvent composition, centrifugal force, duration and temperature to facilitate >95% recovery, and enrichment of low-M r components from human plasma. Using this protocol, >260 unique peptides can be identified from a single plasma profiling experiment using 100 μL of plasma (Greening and Simpson, J Proteomics 73:637-648, 2010). The efficacy of this method is demonstrated by the identification, for the first time, of several plasma proteins (e.g., protein KIAA0649 (Q9Y4D3), rheumatoid factor D5, serine protease inhibitor A3, and transmembrane adapter protein PAG) previously not reported in extant high-confidence Human Proteome Organization Plasma Proteome Project datasets. © 2011 Springer Science+Business Media, LLC.
Additional file 2 of “I do not know the advantages of having a general practitioner” - a qualitative study exploring the views of low-acuity emergency patients without a regular general practitioner toward primary care
Creators: name: Kümpel, Lisa
name: Oslislo, Sarah
name: Resendiz Cantu, Rebecca
name: Möckel, Martin
name: Heintze, Christoph
name: Holzinger, Felix
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2
THE EFFECT OF HUMAN CAPITAL CAPABILITIES ON ENTREPRENUERIAL CAPABILITIES AND THE PERFORMANCE OF THAILAND'S SMALL AND MEDIUM ENTERPRISES
Creators: name: Sumittra Jirawuttinunt
name: Pratarnporn Chanin
Publisher: name: Silpakorn University Research and Development Institute
Year: 2018
Subjects: Human capital capabilities
entrepreneurial capabilities
small and medium enterprises

description: Humanities, Arts and Social Sciences Studies, 18, 2, 535-556
Hochschulbibliotheken im Umfeld von Lehre und Lernen
Creators: name: Lazarus, Jens
Publisher: name: Humboldt-Universität zu Berlin
Year: 2002
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Die Arbeit setzt sich mit den Themenbereichen Vermittlung von Informationskompetenz, Einbindung von Informationsvermittlung in die akademische Lehre und Hochschulbibliothek als Lernort auseinander. Die Entwicklung der digitalen Technologie hat wesentlichen Einfluss auf die Lehre und Forschung an den Hochschulen. Vor allem in den USA und in Australien, aber auch in Großbritannien und den skandinavischen Ländern wurde frühzeitig eine veränderte Rolle der Hochschulbibliotheken diskutiert und eine stärkere Beteiligung an der akademischen Ausbildung angestrebt. Ein zentrales Thema ist hierbei die Vermittlung von Informationskompetenz. Darüber hinaus erfolgten oft weitreichende strukturelle Veränderungen. Hochschulbibliotheken wurden unter Einbeziehung von Rechenzentren und anderen Dienstleistungseinrichtungen zu Learning Centers. In Deutschland liegt der Schwerpunkt bislang auf einer Verbesserung des Informationsangebotes durch Digitalisierung und Erschließung von und Zugang zu digitalen Informationen. Diese Arbeit möchte den Stand der Diskussion zur Rolle der Hochschulbibliotheken in Lehre und Lernen unter dem Aspekt wachsender Bedeutung elektronischer Dienstleistungen zusammenführen und ein Gesamtbild der Situation vermitteln. In einem zweiten Teil wird versucht, Schlussfolgerungen zu ziehen und ein strategisches Konzept für die Fachhochschule Merseburg zu entwickeln.
THE GRAMMATICAL DEVELOPMENT OF DIRECTIONAL VERBS IN BLACK TAI
Creators: name: Wichaya Bovonwiwat
name: Somsonge Burusphat
Publisher: name: Silpakorn University Research and Development Institute
Year: 2018
Subjects: Directional verbs
Black Tai
grammaticalization
aspect

description: Humanities, Arts and Social Sciences Studies, 18, 2, 399-427
THE MODEL OF TEACHER'S PROFESSIONAL LEARNING COMMUNITY FOR THE NON-FORMAL AND INFORMAL EDUCATIONAL CENTER IN THAILAND'S UPPER NORTHERN REGION
Creators: name: Prapaphon Kham-O-Part
Publisher: name: Silpakorn University Research and Development Institute
Year: 2018
Subjects: Professional learning community
teachers' professional learning community
non-formal and informal education

description: Humanities, Arts and Social Sciences Studies, 18, 2, 443-462
sj-docx-1-ire-10.1177_00471178221140087 – Supplemental material for The limits of US national identity: interests and values in US military aid
Creators: name: Sandlin, Evan W
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, sj-docx-1-ire-10.1177_00471178221140087 for The limits of US national identity: interests and values in US military aid by Evan W Sandlin in International Relations
WESLEYAN MISSION MEDICINE IN ASANTE (1901-2000)
Creators: name: Adu-Gyamfi, Samuel
name: Oware's, Richard
Publisher: name: Silpakorn University Research and Development Institute
Year: 2018
Subjects: Wesleyan Missionary
medicine
traditional medical practitioners
healthcare

description: Humanities, Arts and Social Sciences Studies, 18, 2, 335-376
sj-docx-1-tva-10.1177_15248380221137043 – Supplemental material for A Scoping Review of Programs to Prevent Child Sexual Abuse in Mainland China
Creators: name: Luan, Hui
name: Wan, Guowei
name: Sun, Xijuan
name: Niu, Jialu
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental material, sj-docx-1-tva-10.1177_15248380221137043 for A Scoping Review of Programs to Prevent Child Sexual Abuse in Mainland China by Hui Luan, Guowei Wan, Xijuan Sun and Jialu Niu in Trauma, Violence, & Abuse