cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bus commuting, subway commuting, and walking to workplaces in US cities: Socioeconomic factors of transit commuters
Creators: name: Lee, Bun Song
name: Wohar, Mark E.
name: Daiho Uhm
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Most previous studies that examine the controversies involved in transit subsidies concentrate on large metropolitan areas in the United States. The main contribution of this article to the extant literature is that it investigates bus ridership data in small- and medium-sized US cities, which has been primarily ignored in earlier literature. The article also analyzes data on bus commuters, subway commuters, and walkers to workplaces in the eight largest cities with extensive subway systems and 22 other large cities. The analysis employs the 2010 US Census (IPUMS data). Generally, the characteristics of subway commuters are quite different from those of bus commuters. The characteristics of walkers in all the US cities are very similar to those who commute by bus.
The host range of four new biotypes of Dactylopius tomentosus (Hemiptera: Dactylopiidae) from southern USA and their potential as biological control agents of Cylindropuntia spp. (Cactaceae) in Australia: Part II.
Creators: name: P.K. Jones
name: R.H. Holtkamp
name: M.D. Day
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Eight Cylindropuntia species have naturalised in Australia and pose serious economic, environmental and social impacts. Two biotypes of Dactylopius tomentosus have been used as bio-control agents to control different Cylindropuntia species. The host range of four additional biotypes of Dactylopius tomentosus from southern USA was investigated. Feeding and development were restricted to the genus Cylindropuntia. However, they showed differences in specificity within this genus and some biotypes discriminated between the provenances of C. rosea and C. tunicata. Efficacy trials were conducted to determine whether populations of each biotype could be sustained on the naturalised Cylindropuntia species and if these populations could retard the growth or kill these plants. The ‘acanthocarpa’ biotype offers potential control of C. rosea (Lorne Station), while the ‘cylindropuntia sp.’ biotype shows great potential to control C. rosea (Grawin). The ‘cylindropuntia sp.’ biotype also had a high impact on C. kleiniae and C. imbricata, and a moderate impact on C. leptocaulis and C. prolifera. The ‘acanthocarpa X echinocarpa’ biotype had its greatest impact on C. tunicata (Grawin), killing this plant in 18 weeks. A fourth biotype, ‘leptocaulis’, was damaging to some species, but was less effective than the other biotypes. Cylindropuntia spinosior is the only naturalised species in Australia where no effective biocontrol agent has been found.
Bus commuting, subway commuting, and walking to workplaces in U.S. cities: Socioeconomic factors of transit commuters
Creators: name: Lee, Bun Song
name: Wohar, Mark E.
name: Daiho Uhm
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Most previous studies that examine the controversies involved in transit subsidies concentrate on large metropolitan areas in the U.S. The main contribution of this paper to the extant literature is that it investigates bus ridership data in small- and medium-sized U.S. cities, which has been primarily ignored in earlier literature. The paper also analyzes data on bus commuters, subway commuters, and walkers to workplaces in the 8 largest cities with extensive subway systems and the 22 other large cities. The analysis employs the 2010 U.S. Census (IPUMS data). Generally, the characteristics of subway commuters are quite different from those of bus commuters. The characteristics of walkers in all the U.S. cities are very similar to those who commute by bus.
FOLK SCHOOLS – CONTEMPORARY ASPECTS ON AN OLD FORM OF NON-FORMAL ADULT EDUCATION
Creators: name: Damianek, Cyprian
Publisher: name: figshare
Year: 2016
Subjects: subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: Developmental and Educational Psychology

description: "Non-formal adult education" comprises procedures of teaching and education that only to a limited degree are part of the formal, public educational system. Non-formal learning activities are frequently based on private initiatives by non-governmental organizations (NGOs). Folk schools are a form of non-formal adult education and are based on fellowship/community and the philosophy of the individual providers. Folk schools were originally schools for adult men and women, which was given a teaching, which aimed to make them good citizens. Over time, the focus was more on personal development, and often specialize individual schools are particularly in parts of this. The main scope of voluntary non-formal adult learning in associations is, taking a starting point in the activity and the binding fellowship, to reinforce non-formal adult knowledge and thus the affiliates’ skill and wish to take an obligation for their own lives and to play a dynamic and engaged part in society.
Characterization of foxing stains in early twentieth century photographic and paper materials
Creators: name: Modica, Aurora
name: Bruno, Maurizio
name: Bella, Marco Di
name: Alberghina, Maria Francesca
name: Brai, Maria
name: Fontana, Dorotea
name: Tranchina, Luigi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences

description: The subject of this present work is a group of nine historical pictures shot in Palermo by the Sicilian photographer E. Interguglielmi in 1912. They are nine matte-collodion prints mounted on the original cardboard supports and all of them show foxing stains affecting the paper surface. In order to characterise the chemical composition of the supports and investigate foxing spots, non-destructive and micro-destructive analysis were carried out. X-rays fluorescence (XRF) analysis was used to characterise the elemental composition of all the mounting boards, allowing a comparison between the foxing spots and non-affected areas. Laser-Induced Breakdown Spectroscopy was used to investigate the presence of lower atomic number elements, not detectable by XRF, while SEM imaging allowed the investigation of surface appearance and nature of original paper samples from the cardboards.
Facile one-pot synthesis of novel dicyanoanilines fused to tetrahydro-4H-thiopyran-4-one ring via Et3N/H2O catalyzed pseudo four-component reaction
Creators: name: M. Saeed Abaee
name: Soodabeh Forghani
name: Mojtahedi, Mohammad M.
name: Harms, Klaus
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: A facile procedure is developed for one-pot synthesis of a new group of dicyanoanilines. Tetrahydro-4H-thiopyran-4-one, 1, undergoes a pseudo four-component reaction with various aldehydes bearing different groups and two equivalents of malononitrile in aqueous media in the presence of triethylamine (Et3N). As a result, novel thiopyran-fused dicyanoanilines 4 are formed efficiently in the reaction mixtures in 90–97% yield within 9–12 h mixing at 40°C. Due to the polarity of the medium, products precipitate in the mixture spontaneously allowing for easy purification by recrystallization avoiding cumbersome chromatographic separations. Characterization of the products was performed by spectroscopic methods and, in one case, was further supported by X-ray crystallographic experiments.
Pyridothiadiazine derivatives as aldose reductase inhibitors having antioxidant activity
Creators: name: Shaojuan Zhu
name: Shuzhen Zhang
name: Hao, Xin
name: Xiangyu Qin
name: Shagufta Parveen
name: Shaoqi Yang
name: Ma, Bing
name: Changjin Zhu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences

description: A series of aldose reductase (ALR2) inhibitors based on pyridothiadiazine were prepared and evaluated for their activities in ALR2 inhibition, DPPH scavenging, and MDA inhibition. Comparison studies were carried out between analogs having either hydroxyl or methoxy groups substituted on the N2-benzyl side chains of the compounds. Most of the hydroxy-substituted compounds were found to be more potent compared to their methoxy-substituted analogs with respect to DPPH inhibition (>93%) and MDA inhibition (>73%). However, ALR2 inhibitory activity was found to be affected by the electron-withdrawing substituent at the C7 position in addition to the effect of the N2-substituted benzyl group. These results provide an array of multifunctional ALR2 inhibitors possessing capacities both for ALR2 inhibition and as antioxidants.
Nutrition behaviors, perceptions, and beliefs of recent marathon finishers
Creators: name: Wilson, Patrick B.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: To describe the nutrition behaviors, perceptions, and beliefs of marathoners. Methods: A survey-based study was conducted with 422 recent marathon finishers (199 men, 223 women). Participants reported their running background, demographics, diets followed, supplements used, and food/fluid intake during their most recent marathon (median 7 days prior), as well as beliefs about hydration, fueling, and sources of nutrition information. Results: Median finishing times were 3:53 (3:26–4:35) and 4:25 (3:50–4:59) h:min for men and women during their most recent marathon. Most participants (66.1%) reported typically following a moderate-carbohydrate, moderate-fat diet, while 66.4% carbohydrate-loaded prior to their most recent marathon. Among 139 participants following a specific diet over the past year, the most common were vegetarian/vegan/pescatarian (n = 39), Paleolithic (n = 16), gluten-free (n = 15), and low-carbohydrate (n = 12). Roughly 35% of participants took a supplement intended to improve running performance over the past month. Women were more likely to follow specific diets (39.0% vs. 26.1%), while men were more likely to recently use performance-enhancing supplements (40.2% vs. 30.0%). Most participants (68.3%) indicated they were likely or very likely to rely on a structured plan to determine fluid intake, and 75% were confident in their ability to hydrate. At least 35.6% of participants thought they could improve marathon performance by 8% or more with nutrition interventions. Scientific journals ranked as the most reliable source of nutrition information, while running coaches ranked as the most likely source to be utilized. Conclusions: Findings from this investigation, such as diets and supplements utilized by marathoners, can be used by practitioners and researchers alike to improve the dissemination of scientifically-based information on nutrition and marathon running.
Steroid constituents from the soft coral Sinularia microspiculata
Creators: name: Nguyen Van Thanh
name: Ninh Thi Ngoc
name: Anh, Hoang Le Tuan
name: Thung, Do Cong
name: Thao, Do Thi
name: Nguyen Xuan Cuong
name: Nguyen Hoai Nam
name: Kiem, Phan Van
name: Minh, Chau Van
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A methanol extract of the soft coral Sinularia microspiculata revealed five sterols, including two new compounds. Using combined chromatographic and spectroscopic experiments, the new compounds were found to be 7-oxogorgosterol (1) and 16α-hydroxysarcosterol (2). Their structures were determined on the basis of spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, and FT-ICR-MS) and by comparing obtained results to the values indicated in previous studies. Among the isolated compounds, 3 showed weak cytotoxic effects against HL-60 (IC50  = 89.02 ± 9.93 μM) cell line, whereas 5 was weakly active against HL-60 (IC50  = 82.80 ± 13.65 μM) and SK-Mel2 (IC50  = 72.32 ± 1.30 μM) cell lines.
Flexible objective Bayesian linear regression with applications in survival analysis
Creators: name: Rubio, Francisco J.
name: Keming Yu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: We study objective Bayesian inference for linear regression models with residual errors distributed according to the class of two-piece scale mixtures of normal distributions. These models allow for capturing departures from the usual assumption of normality of the errors in terms of heavy tails, asymmetry, and certain types of heteroscedasticity. We propose a general non-informative, scale-invariant, prior structure and provide sufficient conditions for the propriety of the posterior distribution of the model parameters, which cover cases when the response variables are censored. These results allow us to apply the proposed models in the context of survival analysis. This paper represents an extension to the Bayesian framework of the models proposed in [16]. We present a simulation study that shows good frequentist properties of the posterior credible intervals as well as point estimators associated to the proposed priors. We illustrate the performance of these models with real data in the context of survival analysis of cancer patients.
Investigation on Effect of Acid Wash with Thermocol Ball on Physical Properties of Knitted Garments
Creators: name: Khalil, Elias
Publisher: name: figshare
Year: 2016
Subjects: subject: 91012 Textile Technology
subject: FOS: Materials engineering

description: Washing is considered as the final process of garments finishing. Acid washing is one kind of finishing treatment used for making sewn garments aesthetic, fashionable, soft, comfortable and also adding value to the final garments. This paper investigates the effect of the acid washing (with thermocol balls and potassium permanganate) on different physical properties of three knitted garments (Single Jersey 100% Cotton T-shirt, Single Jersey 95% Cotton 5% Spandex T-Shirt and 1 × 1 Rib100% Cotton T-Shirt). Typical washing procedures and techniques were followed and then physical properties were analyzed under standard condition. It is observed that fabric weight, CPI, WPI, spirality and shrinkage increase while bursting strength, stitch length absorbency decrease after washing treatment. pH of all the samples is under controlled and lies between 7 to 8. There is no change in pilling, colorfastness to wash, water and dry rubbing while a little bit decrease in wet rubbing.
Suppression of rolling circle amplification by nucleotide analogs in circular template for three DNA polymerases
Creators: name: Suming Tang
name: Wei, Hua
name: Tianyu Hu
name: Jiquan Jiang
name: Jinglin Chang
name: Yifu Guan
name: Guojie Zhao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Among wide applications of nucleotide analogs, their roles in enzyme catalytic reactions are significant in both fundamental and medical researches. By introducing analogs into circular templates, we succeeded in determining effects of four analogs on RCA efficiency for three different DNA polymerases. Results showed an obvious suppression effect for 2′-OMeRNA modification, which might be due to the size of the C2′-modified moieties. 2′-F RNA, LNA and PS had little interference, suggesting good analog candidates for application in RCA. Different polymerases and nucleobases made a little difference according to analogs we used. These results are useful for understanding polymerase catalytic mechanism and analogs applications in RCA reaction. Schematic of RCA affected by nucleotide analogs. (A) The structure comparison of DNA and nucleotide analogs used. (B) Analogs were substituted in circular template for RCA.
Insulin glargine use and breast cancer risk: Associations with cumulative exposure
Creators: name: Peeters, Paul J. H. L.
name: Bazelier, Marloes T.
name: Leufkens, Hubert G. M.
name: Auvinen, Anssi
name: Staa, Tjeerd P. Van
name: Vries, Frank De
name: Bruin, Marie L. De
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Background: This study was aimed to assess the risk of breast cancer associated with exposure to insulin glargine in women with type 2 diabetes and evaluate whether the pattern of risk concurs with the hypothesized trend of an increase in risk with longer duration of use, taking into account previous cumulative exposure to other types of insulin. Methods: We performed a restrospective cohort study (2002–2013) in the Clinical Practice Research Datalink among adult female patients with a first ever insulin prescription (n = 12 468). Time-dependent exposure measures were used to assess associations with duration of use of: (1) other insulin types before glargine was first prescribed (i.e. among switchers); and (2) of glargine during follow-up. Analyses were performed separately for insulin-naïve glargine users and patients switched to glargine. Cox proportional hazards models were used to derive p-trends, hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer associated with glargine use. Results: During 66 151 person years, 186 breast cancer cases occurred; 76 in glargine users (3.0/1000 years) and 110 in users of other insulins (2.7/1000 years). Among insulin-naïve women, no association with cumulative glargine use was observed (p-trend = 0.91), even after ≥5 years (HR = 1.06, 95% CI 0.48–2.33). Among switchers, a linear trend with years of prior exposure to other insulins was found (p-trend = 0.02). An increased risk was observed in glargine users with extensive (>3 years) past exposure to other insulins (HR = 3.17, 95% CI 1.28–7.84). A non-significant trend with cumulative glargine exposure was found among switchers (p-trend = 0.24). Conclusions: Exposure to glargine was not associated with an increased breast cancer risk in insulin-naïve patients. Exposure to other insulins prior to the start of glargine appears to be relevant when studying breast cancer risk associated with glargine use.
CIDADANIA, PRINCÍPIO DA RAZOABILIDADE E O PROBLEMA DO ATO DE IMPROBIDADE ADMINISTRATIVA CULPOSO
Creators: name: Bertoncini, Mateus Eduardo Siqueira
name: MAURÍCIO AUGUSTO GARBIN
Publisher: name: figshare
Year: 2016
Subjects: subject: Law
subject: FOS: Law

description: The article’s goal is to study the act of culpable administrative misconduct. To do so, one proceeds to the doctrinal and jurisprudential analysis of Law 8.429/92, it’s context and objectives. One examines the types of act of administrative misconduct. We are studying the possibility of attesting the act of culpable administrative misconduct. It’s emphasized that no legal distinction between willful and culpable misconduct in relation to the gradation of sanctions, proposing the end, the way to address this gap.
MMDS Report - Twitter User Personality Prediction
Creators: name: Vishal Bhalla
Publisher: name: figshare
Year: 2016
Subjects: subject: 80707 Organisation of Information and Knowledge Resources
subject: FOS: Media and communications
subject: 80109 Pattern Recognition and Data Mining
subject: FOS: Computer and information sciences
subject: 80709 Social and Community Informatics
subject: 80107 Natural Language Processing
subject: Distributed Computing
subject: 80605 Decision Support and Group Support Systems
subject: Applied Computer Science

description: This project report focuses on a novel concept of using social media data of a particular user to reflect the underlying personality. In particular, we have stressed on user tweets to gauge the personality trait among a predefined list of personality types.
The team has implemented an end to end Personality Prediction model in Python with all considerations involved in a typical Machine Learning pipeline. As such, the system can be used as a benchmark or an extension to build upon further complex models on other social media platforms.
Meta-Analytic Framework for Sparse K-Means to Identify Disease Subtypes in Multiple Transcriptomic Studies
Creators: name: Zhiguang Huo
name: Ding, Ying
name: Liu, Silvia
name: Oesterreich, Steffi
name: Tseng, George
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Disease phenotyping by omics data has become a popular approach that potentially can lead to better personalized treatment. Identifying disease subtypes via unsupervised machine learning is the first step toward this goal. In this article, we extend a sparse K-means method toward a meta-analytic framework to identify novel disease subtypes when expression profiles of multiple cohorts are available. The lasso regularization and meta-analysis identify a unique set of gene features for subtype characterization. An additional pattern matching reward function guarantees consistent subtype signatures across studies. The method was evaluated by simulations and leukemia and breast cancer datasets. The identified disease subtypes from meta-analysis were characterized with improved accuracy and stability compared to single study analysis. The breast cancer model was applied to an independent METABRIC dataset and generated improved survival difference between subtypes. These results provide a basis for diagnosis and development of targeted treatments for disease subgroups. Supplementary materials for this article are available online.
Distinct role of Arabidopsis mitochondrial P-type pentatricopeptide repeat protein-modulating editing protein, PPME, in nad1 RNA editing
Creators: name: Kuan-Chieh Leu
name: Ming-Hsiun Hsieh
name: Huei-Jing Wang
name: Hsu-Liang Hsieh
name: Guang-Yuh Jauh
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: The mitochondrion is an important power generator in most eukaryotic cells. To preserve its function, many essential nuclear-encoded factors play specific roles in mitochondrial RNA metabolic processes, including RNA editing. RNA editing consists of post-transcriptional deamination, which alters specific nucleotides in transcripts to mediate gene expression. In plant cells, many pentatricopeptide repeat proteins (PPRs) participate in diverse organellar RNA metabolic processes, but only PLS-type PPRs are involved in RNA editing. Here, we report a P-type PPR protein from Arabidopsis thaliana, P-type PPR-Modulating Editing (PPME), which has a distinct role in mitochondrial nad1 RNA editing via RNA binding activity. In the homozygous ppme mutant, cytosine (C)-to-uracil (U) conversions at both the nad1-898 and 937 sites were abolished, disrupting Arg300-to-Trp300 and Pro313-to-Ser313 amino acid changes in the mitochondrial NAD1 protein. NAD1 is a critical component of mitochondrial respiration complex I; its activity is severely reduced in the homozygous ppme mutant, resulting in significantly altered growth and development. Both abolished RNA editing and defective complex I activity were completely rescued by CaMV 35S promoter- and PPME native promoter-driven PPME genomic fragments tagged with GFP in a homozygous ppme background. Our experimental results demonstrate a distinct role of a P-type PPR protein, PPME, in RNA editing in plant organelles.
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
Creators: name: Tasnim Dayeh
name: Tiinamaija Tuomi
name: Almgren, Peter
name: Perfilyev, Alexander
name: Per-Anders Jansson
name: Mello, Vanessa D. De
name: Pihlajamäki, Jussi
name: Vaag, Allan
name: Groop, Leif
name: Nilsson, Emma
name: Ling, Charlotte
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this study was to examine whether 5 DNA methylation loci in blood DNA (ABCG1, PHOSPHO1, SOCS3, SREBF1, and TXNIP), recently reported to be associated with T2D, might predict future T2D in subjects from the Botnia prospective study. We also tested if these CpG sites exhibit altered DNA methylation in human pancreatic islets, liver, adipose tissue, and skeletal muscle from diabetic vs. non-diabetic subjects. DNA methylation at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future T2D (OR = 1.09, 95% CI = 1.02–1.16, P-value = 0.007, Q-value = 0.018), while DNA methylation at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future T2D (OR = 0.85, 95% CI = 0.75–0.95, P-value = 0.006, Q-value = 0.018) after adjustment for age, gender, fasting glucose, and family relation. Furthermore, the level of DNA methylation at the ABCG1 locus cg06500161 in blood DNA correlated positively with BMI, HbA1c, fasting insulin, and triglyceride levels, and was increased in adipose tissue and blood from the diabetic twin among monozygotic twin pairs discordant for T2D. DNA methylation at the PHOSPHO1 locus cg02650017 in blood correlated positively with HDL levels, and was decreased in skeletal muscle from diabetic vs. non-diabetic monozygotic twins. DNA methylation of cg18181703 (SOCS3), cg11024682 (SREBF1), and cg19693031 (TXNIP) was not associated with future T2D risk in subjects from the Botnia prospective study.
Distinct role of Arabidopsis mitochondrial P-type pentatricopeptide repeat protein-modulating editing protein, PPME, in nad1 RNA editing
Creators: name: Kuan-Chieh Leu
name: Ming-Hsiun Hsieh
name: Huei-Jing Wang
name: Hsu-Liang Hsieh
name: Guang-Yuh Jauh
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: The mitochondrion is an important power generator in most eukaryotic cells. To preserve its function, many essential nuclear-encoded factors play specific roles in mitochondrial RNA metabolic processes, including RNA editing. RNA editing consists of post-transcriptional deamination, which alters specific nucleotides in transcripts to mediate gene expression. In plant cells, many pentatricopeptide repeat proteins (PPRs) participate in diverse organellar RNA metabolic processes, but only PLS-type PPRs are involved in RNA editing. Here, we report a P-type PPR protein from Arabidopsis thaliana, P-type PPR-Modulating Editing (PPME), which has a distinct role in mitochondrial nad1 RNA editing via RNA binding activity. In the homozygous ppme mutant, cytosine (C)-to-uracil (U) conversions at both the nad1-898 and 937 sites were abolished, disrupting Arg300-to-Trp30 and Pro313-to-Ser313 amino acid changes in the mitochondrial NAD1 protein. NAD1 is a critical component of mitochondrial respiration complex I; its activity is severely reduced in the homozygous ppme mutant, resulting in significantly altered growth and development. Both abolished RNA editing and defective complex I activity were completely rescued by CaMV 35S promoter- and PPME native promoter-driven PPME genomic fragments tagged with GFP in a homozygous ppme background. Our experimental results demonstrate a distinct role of a P-type PPR protein, PPME, in RNA editing in plant organelles.
Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep
Creators: name: Jawinski, Philippe
name: Tegelkamp, Sophie
name: Sander, Christian
name: Häntzsch, Madlen
name: Huang, Jue
name: Mauche, Nicole
name: Scholz, Markus
name: Spada, Janek
name: Ulke, Christine
name: Burkhardt, Ralph
name: Reif, Andreas
name: Hegerl, Ulrich
name: Hensch, Tilman
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Dopamine has been implicated in the regulation of sleep–wake states and the circadian rhythm. However, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-O-methyltransferase Val158Met (COMT Val158Met; rs4680) and the dopamine D4 receptor Exon III variable-number-of-tandem-repeat polymorphism (DRD4 VNTR). Pursuing a multi-method approach, we examined their potential effects on circadian preferences, arousal regulation and sleep. Subjects underwent a 7-day actigraphy assessment (SenseWear Pro3), a 20-minute resting EEG (analyzed using VIGALL 2.0) and a body mass index (BMI) assessment. Further, they completed the Morningness–Eveningness Questionnaire (MEQ), the Epworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI). The sample comprised 4625 subjects (19–82 years) genotyped for COMT Val158Met, and 689 elderly subjects (64–82 years) genotyped for DRD4 VNTR. The number of subjects varied across phenotypes. Power calculations revealed a minimum required phenotypic variance explained by genotype ranging between 0.5% and 1.5% for COMT Val158Met and between 3.3% and 6.0% for DRD4 VNTR. Analyses did not reveal significant genotype effects on MEQ, ESS, PSQI, BMI, actigraphy and EEG variables. Additionally, we found no compelling evidence in sex- and age-stratified subsamples. Few associations surpassed the threshold of nominal significance (p < .05), providing some indication for a link between DRD4 VNTR and daytime sleepiness. Taken together, in light of the statistical power obtained in the present study, our data particularly suggest no impact of the COMT Val158Met polymorphism on circadian preferences, arousal regulation and sleep. The suggestive link between DRD4 VNTR and daytime sleepiness, on the other hand, might be worth investigation in a sample enriched with younger adults.
N-Isocyaniminotriphenylphosphorane (Ph3PNNC) as a metal-free catalyst for the synthesis of functionalized isoindoline-1-ones
Creators: name: Rezaei, Aram
name: Ramazani, Ali
name: Ahankar, Hamideh
name: Ganjeie, Bijan
name: Joo, Sang Woo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: A novel application in the field of N-isocyaniminotriphenylphosphorane (Ph3PNNC) chemistry has been introduced in this work. A series of substituted isoindolin-1-one ring systems has been successfully synthesized through a novel and efficient multicomponent reaction of methyl 2-formylbenzoate and primary amines in the presence of N-isocyaniminotriphenylphosphorane (Ph3PNNC) as a catalyst. This one-pot three component reaction (3-CR) gives high yield using N-isocyaniminotriphenylphosphorane (Ph3PNNC) as a metal-free catalyst under mild conditions.
Interaction according to urinary sodium excretion level on the association between ATP2B1 rs17249754 and incident hypertension: the Korean genome epidemiology study
Creators: name: Sunghee Lee
name: Kim, Seong Hwan
name: Shin, Chol
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Objective: We examined an interaction according to the estimated 24-h urinary sodium excretion on the association between ATP2B1 rs17249754 and incident hypertension. Methods: We assessed the incidence of hypertension in 1780 participants aged 45 to 75 years without cardiovascular diseases. DNA genotyping was performed using the Affymetrix Single Nucleotide Polymorphism (SNP) array 5.0. Because of previously reported associations with hypertension in various populations including Koreans, ATP2B1 rs17249754 was determined. Sodium intake was assessed by estimating the 24-h urinary sodium excretion with a Kawasaki formula from a spot urine sample. We utilized Cox proportional hazard models to test an interaction according to urinary sodium excretion on the association between ATP2B1 rs17249754 and incident hypertension. Results: The incident hypertension was increased as sodium excretion level was increased. We confirmed that the ATP2B1 rs17249754 polymorphism had significant association with hypertension. We found that the association was modified by urinary sodium excretion level (p-value = 0.006); the mutant type (AA allele, previously recognized as a protective allele) with <4 g/day urinary sodium excretion had an inverse association on hypertension compared with the wild types (GG+GA) (HR = 0.39, 95% confidence interval (CI) 0.17–0.90), whereas the mutant type with ≥6 g/day urinary sodium demonstrated a significantly increased risk of hypertension (HR = 1.89, 95% CI 1.05–3.43). Conclusions: In this 6-year longitudinal study, our findings suggest that excessive sodium intake estimated from urinary sodium excretion significantly modified the risk of developing hypertension associated with ATP2B1 rs17249754 genetic trait. That is, carriers with ATP2B1 rs17249754 homozygote mutant allele may be at higher risk of hypertension, when they consume excessive sodium intake.
title: Diversität und Teamkreativität : Grundlagen und Methoden zur Zusammenarbeit im Innovationskontext
Creators: name: Stalder, Pia
name: Gisin, Leila
Publisher: name: Lucerne University of Applied Sciences and Arts and HEIG-VD, Haute Ecole d'Ingénierie et de Gestion du Canton de Vaud
Year: 2022

description: Teamkreativität ist entscheidend für den Unternehmenserfolg, Diversität eine wichtige Dimension davon. Dieses White Paper beleuchtet das Thema und stellt Methoden zur Förderung der Zusammenarbeit vor.
DNA methylation of loci withinABCG1andPHOSPHO1in blood DNA is associated with future type 2 diabetes risk
Creators: name: Tasnim Dayeh
name: Tiinamaija Tuomi
name: Almgren, Peter
name: Perfilyev, Alexander
name: Per-Anders Jansson
name: Mello, Vanessa D. De
name: Pihlajamäki, Jussi
name: Vaag, Allan
name: Groop, Leif
name: Nilsson, Emma
name: Ling, Charlotte
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this study was to examine whether five DNA methylation loci in blood DNA (ABCG1, PHOSPHO1, SOCS3, SREBF1, and TXNIP), recently reported to be associated with T2D, might predict future T2D in subjects from the Botnia prospective study. We also tested if these CpG sites exhibit altered DNA methylation in human pancreatic islets, liver, adipose tissue, and skeletal muscle from diabetic versus non-diabetic subjects. DNA methylation at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future T2D (OR = 1.09, 95% CI = 1.02−1.16, P-value = 0.007, Q-value = 0.018), while DNA methylation at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future T2D (OR = 0.85, 95% CI = 0.75−0.95, P-value = 0.006, Q-value = 0.018) after adjustment for age, gender, fasting glucose, and family relation. Furthermore, the level of DNA methylation at the ABCG1 locus cg06500161 in blood DNA correlated positively with BMI, HbA1c, fasting insulin, and triglyceride levels, and was increased in adipose tissue and blood from the diabetic twin among monozygotic twin pairs discordant for T2D. DNA methylation at the PHOSPHO1 locus cg02650017 in blood correlated positively with HDL levels, and was decreased in skeletal muscle from diabetic versus non-diabetic monozygotic twins. DNA methylation of cg18181703 (SOCS3), cg11024682 (SREBF1), and cg19693031 (TXNIP) was not associated with future T2D risk in subjects from the Botnia prospective study.
Content-preserving reconstruction of Electronic Music Sessions using freely available musical building-blocks
Creators: name: Novillo Villegas, Pablo
Publisher: name: Zenodo
Year: 2015
Subjects: open source
reconstruction
electronic music
multitrack

description: We present a system for creating new versions of a given song (“Seed Song”). The principal novelty in our approach centres on the use of multitrack audio session to extract more accurate and specific information, rather than use the final mix of that song. The system analyses every audio track of the audio session to extract features that will help preserving the melodic\tonal, rhythm and timbre content of the “Seed Song”. Then the system reconstructs the song using freely available audios from the Freesound Community. Central to our system is an objective (melodic\tonal preservation, rhythm preservation, timbre preservation) and subjective (originality and interestingness) evaluation via a listening test to examine the listener’s acceptance of the songs created by the system.
Long-acting Muscarinic Antagonist Versus Inhaled Corticosteroid when Added to Long-acting β-agonist for COPD: A Meta-analysis
Creators: name: Oba, Yuji
name: Chandran, Arul V.
name: Devasahayam, Joe V.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The purpose of this study was to systematically review the efficacy and safety of long-acting β-agonist/long-acting muscarinic antagonist (LABA/LAMA) and LABA/inhaled corticosteroid (ICS) combinations in patients with advanced chronic obstructive pulmonary disease (COPD). Randomized clinical trials of at least 12 weeks of duration comparing LABA/LAMA and LABA/ICS combinations were included. We chose forced expiratory volume in 1 second (FEV1), St. George's Respiratory Questionnaire (SGRQ) score, Transitional Dyspnea Index (TDI), COPD Assessment Test (CAT) score, COPD exacerbations, mortality, and other safety parameters as outcome assessment criteria. We included six randomized controlled trials with a total of 4,319 patients. Most patients did not have a history of exacerbation. LABA/LAMA was associated with greater improvement in FEV1 than LABA/ICS (mean difference (MD) 0.09L, 95%confidence interval (CI) 0.07 to 0.11L; high certainty). Two treatments appeared clinically equivalent in improving SGRQ (MD −0.12, 95%CI −1.16 to 0.92; high certainty), TDI (MD 0.15, 95%CI −0.05 to 0.35; high certainty), and CAT scores (MD 0.28 95%CI −0.29 to 0.85; moderate certainty). LABA/LAMA was associated with an absolute reduction of approximately 8% in the incidence of pneumonia compared with LABA/ICS (risk ratio 0.41, 95%CI 0.18 to 0.94; moderate certainty). There was no significant difference in safety and exacerbation outcomes. However, equivalence of two treatments could not be concluded due to imprecision especially for mortality, cardiac serious adverse events, and severe exacerbations. Our findings support the use of dual long-acting bronchodilators for patients with advanced COPD but without frequent exacerbations given the excess risk of pneumonia with LABA/ICS.
Investigating scalar implicatures in a truth-value judgement task: evidence from event-related brain potentials
Creators: name: Spychalska, Maria
name: Kontinen, Jarmo
name: Werning, Markus
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: It is considered underinformative to say Some As are B when it is known that all As are B. Such underinformative sentences receive divergent truth-value judgements: whereas so-called logical responders evaluate them to be true, pragmatic responders reject them as false. In a sentence-picture verification experiment, we found that the split in the behavioural responses correlates with the difference in the event-related potentials (ERP) signal (N400 and P600) recorded for underinformative and for unambiguously true or false sentences with some. However, the ERP patterns for sentences with all are similar for both groups. In contrast to previous findings, the effect is independent of the subjects' autistic spectrum quotients. Assuming that the N400 amplitude is inversely correlated with the expected probability of the critical word we argue that the observed between-group difference in the ERP pattern can be explained by the hypothesis that ‘logicians’ and ‘pragmatists’ use distinct verification strategies in evaluating sentences with the quantifier some.
Kinetic studies for nitrate adsorption on granular chitosan–Fe(III) complex
Creators: name: Qili Hu
name: Chen, Nan
name: Chuanping Feng
name: Weiwu Hu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: In this study, a generalized kinetic equation was proposed to simulate adsorption behaviors in batch systems and several useful kinetic equations were deduced. The results indicated that the amount of nitrate uptake increased rapidly in the initial stage, followed by a slower process until adsorption equilibrium was reached after approximately 1.5 h. The rate constant was a function of the initial nitrate concentration. The adsorption and desorption rate constants quantitatively reflected the adsorption and desorption reactions at the solid/solution interface. The adsorption and desorption processes for nitrate adsorption followed identical reaction order. The kinetic parameters (adsorption and desorption rate constants, half-time and instantaneous rate) provided by these kinetic equations are of significant importance for the understanding of adsorption mechanisms.