cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Retinal angiogenesis suppression through small molecule activation of p53
Creators: name: Penn, John S.
name: Ambati, Jayakrishna
name: Cicatiello, Valeria
name: Tudisco, Laura
name: Claros, Nidia
name: Kim, Younghee
name: Guaiquil, Victor H.
name: Yanni, Susan
name: Kerur, Nagaraj
name: Rafii, Shahin
name: Lee, Thomas C.
name: Hauswirth, William W.
name: Milde, Till
name: Chavala, Sai H.
name: De Falco, Sandro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Neovascular age-related macular degeneration is a leading cause of irreversible vision loss in the Western world. Cytokine-targeted therapies (such as anti-vascular endothelial growth factor) are effective in treating pathologic ocular angiogenesis, but have not led to a durable effect and often require indefinite treatment. Here, we show that Nutlin-3, a small molecule antagonist of the E3 ubiquitin protein ligase MDM2, inhibited angiogenesis in several model systems. We found that a functional p53 pathway was essential for Nutlin-3–mediated retinal antiangiogenesis and disruption of the p53 transcriptional network abolished the antiangiogenic activity of Nutlin-3. Nutlin-3 did not inhibit established, mature blood vessels in the adult mouse retina, suggesting that only proliferating retinal vessels are sensitive to Nutlin-3. Furthermore, Nutlin-3 inhibited angiogenesis in nonretinal models such as the hind limb ischemia model. Our work demonstrates that Nutlin-3 functions through an antiproliferative pathway with conceivable advantages over existing cytokine-targeted antiangiogenesis therapies.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (71)]
Creators: name: De Arigonibus, Jacobus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1429
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Jacobus de Arigonibus, Sohn des verstorbenen Beltramus, aus Barzio, gehörig zur plebs von [Cassina] Valsassina im ducatus Mailand, nun wohnhaft in Pavia an der Porta St. Johannis in der Gemeinde St. Michaelis Maioris, verkauft dem Notar Mafiolus de Buziis, Sohn des verstorbenen Rugirolus, wohnhaft an der Porta St. Nazarii in Brolio in Mailand, stellvertretend für die Eremitin Guarischa de Arigonibus aus Barzio, Tochter des verstorbenen Beltramus, bisher wohnhaft am Hospital domini St. Antonii, gelegen oberhalb des cancellus von Concenate auf dem Gebiet von [Cassina] Valassina, ein Grundstück, gelegen in Barzio.
title: Apologie étatique et concorde religieuse. Sur quelques pamphlets de Loys Le Roy
Creators: name: Magno, Luigi
Publisher: name: Roma Tre-Press
Year: 2013

description: Résumé:

A travers une lecture suivie et l’analyse de quelques pamphlets militants écrits par Loys Le Roy pendant les guerres de religion, cette étude essaie de reconstruire la vision de cet humaniste qui se dégage de sa réflexion portant à la fois sur la religion et la politique, afin d’en souligner le caractère composite, l’allure oscillatoire et le voisinage d’idées, parfois en accord, parfois apparemment distantes ou antithétiques, qui s’emboîtent, s’in­fléchissent, cohabitent. Cette réflexion touche en effet à des sujets composites tels l’apologie étatique, la volonté d’une réforme de l’église, la concorde religieuse, l’affirmation d’un principe de paix – en tant que fondement de l’organisation politique – qui ne refuse pas pour autant le recours aux conflits, ou encore l’idée de progrès de l’humanité ou de libre arbitre et le rôle reconnu à l’esprit de l’univers (Providence, Fortune, Nature), voire à Dieu, moteur premier, bref à une série de sujets qui se saisissent les uns des autres et entrent, au fur et à mesure de l’argumentation, dans des rapports changeants d’accord ou d’antithèse.

Abstract:

By analyzing some politically committed pamphlets written by Loys Le Roy during the wars of religion (1562-1598), the aim of this article is to reconstruct the points of view of this humanist which emerge from his reflection on both religion and politics, in order to emphasize his composite ideas and his oscillatory way of thinking whereby ideas fit, inflect, coexist. Le Roy’s pamphlets discuss crucial issues such as state apology, the wish to reform the church, the defence of monarchy, religious concord, the defence of peace (even if Le Roy does not object to the use of violence), free will and the unquestionable power of God. In Le Roy’s writings, these issues inform each other appearing at times coherent and other times in contradiction with each other.
description: KRYPTON – VOL.1 – 2013 – APOLOGIE
Thermal keV dark matter in a gauged B-L model with cosmic inflation
Creators: name: Borah, Debasish
name: Das, Suruj Jyoti
name: Saha, Abhijit Kumar
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the possibility of keV scale thermal dark matter (DM) in a gauged $B - L$ extension of the standard model with three right-handed neutrinos (RHN) and one vector like fermion in the context of cosmic inflation. The complex singlet scalar field responsible for the spontaneous breaking of $B-L$ gauge symmetry is non-minimally coupled to gravity and serves the role of inflaton. The keV scale vector like fermion DM gives rise to the possibility of warm dark matter, but it gets overproduced thermally. The subsequent entropy dilution due to one of the RHN decay can bring the thermal abundance of DM within the observed limit. The dynamics of both the DM and the diluter are regulated by the $B-L$ model parameters which are also restricted by the requirement of successful inflationary dynamics.We constrain the model parameter space from the requirement of producing sufficient entropy dilution to obtain correct DM relic, inflationary observables along with other phenomenological constraints. Interestingly, we obtain unique predictions for the order of lightest active neutrino mass ($m_{ν_l}\lesssim 10^{-14}$ eV) as function of $B-L$ gauge coupling for keV scale DM. The proposed framework also explains the origin of observed baryon asymmetry from the decay of other two heavier RHN by overcoming the entropy dilution effect.
description: 17 pages, 10 captioned figures, matches version accepted for publication in Phys. Rev. D
The genomics of schizophrenia: update and implications
Creators: name: Giusti-Rodríguez, Paola
name: Sullivan, Patrick F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Schizophrenia is strongly familial yet rarely (if ever) exhibits classical Mendelian inheritance patterns. The advent of large-scale genotyping and sequencing projects has yielded large data sets with higher statistical power in an effort to uncover new associations with schizophrenia. Here, we review the challenges in dissecting the genetics of schizophrenia and provide an update of the current understanding of the underlying genomics. We discuss the breadth of susceptibility alleles, including those that may occur with low frequency and high disease risk, such as the 22q11.2 hemideletion, as well as alleles that may occur with greater frequency but convey a lower risk of schizophrenia, such as variants in genes encoding subunits of the voltage-gated L-type calcium channel. Finally, we provide an overview of the clinical implications for the diagnosis and treatment of schizophrenia based on progress in understanding the underlying genetic basis.
On a range of exponents for absence of Lavrentiev phenomenon for double phase functionals
Creators: name: Bulíček, Miroslav
name: Gwiazda, Piotr
name: Skrzeczkowski, Jakub
Publisher: name: arXiv
Year: 2021
Subjects: subject: Analysis of PDEs (math.AP)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 35J60, 35J70, 49N60

description: For a class of functionals having the $(p,q)$-growth, we establish an improved range of exponents $p$, $q$ for which the Lavrentiev phenomenon does not occur. The proof is based on a standard mollification argument and Young convolution inequality. Our contribution is two-fold. First, we observe that it is sufficient to regularise only bounded functions. Second, we exploit the $L^{\infty}$ bound on the function rather than the $L^p$ estimate on the gradient. Our proof does not rely on the properties of minimizers to variational problems but it is rather a consequence of the underlying Musielak-Orlicz function spaces. Moreover, our method works for unbounded boundary data, the variable exponent functionals and vectorial problems. In addition, the result seems to be optimal for $p\le d$.
description: 32 pages
Birationally rigid Fano fibre spaces. II
Creators: name: Pukhlikov, Aleksandr V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14E05, 14E07, 14E08

description: In this paper we prove birational rigidity of large classes of Fano-Mori fibre spaces over a base of arbitrary dimension, bounded from above by a constant that depends on the dimension of the fibre only. In order to do that, we first show that if every fibre of a Fano-Mori fibre space satisfies certain natural conditions, then every birational map onto another Fano-Mori fibre space is fibre-wise. After that we construct large classes of fibre spaces (into Fano double spaces of index one and into Fano hypersurfaces of index one) which satisfy those conditions. The paper is a follow up of my previous work: Pukhlikov A.V., Birationally rigid Fano fibrations, Izvestiya: Mathematics {\bf 64} (2000), No. 3, 563-581.
description: 31 pages
Editorial – International Journal of Sustainable Energy Planning and Management Vol 14
Creators: name: Østergaard, Poul Alberg
Publisher: name: International Journal of Sustainable Energy Planning and Management
Year: 2018

description: This editorial introduces the 14th volume of the International Journal of Sustainable Energy Planning and Management, which addresses transition pathways for Sweden’s transportation sector, and for the West African power system towards low-carbon. Also, industrial symbiosis with the aim of providing district heating in Aalborg and prerequisites for energy transitions are addressed.
description: International Journal of Sustainable Energy Planning and Management, Vol 14 (2017)
Effects of beta function on mass and melting temperature for scalar glueballs in AdS/QCD models at finite temperature
Creators: name: Vega, Alfredo
name: Rodriguez, Amanda
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider an extension to finite temperature in an AdS/ QCD model, which regards anomalous dimension contributions to get a bulk mass depending on beta function. We study the effect of beta function on mass as a function of temperature and melting temperature for scalar glueballs.
description: 6 pages, 3 figures
Type 2 alveolar cells are stem cells in adult lung
Creators: name: Bowie, Emily J.
name: Barkauskas, Christina E.
name: Stripp, Barry R.
name: Randell, Scott H.
name: Rackley, Craig R.
name: Noble, Paul W.
name: Cronce, Michael J.
name: Keene, Douglas R.
name: Hogan, Brigid L.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo clonal lineage analysis, different injury/repair systems, and in vitro culture of purified cell populations to obtain new information about the contribution of AEC2s to alveolar maintenance and repair. Genetic lineage-tracing experiments showed that surfactant protein C–positive (SFTPC-positive) AEC2s self renew and differentiate over about a year, consistent with the population containing long-term alveolar stem cells. Moreover, if many AEC2s were specifically ablated, high-resolution imaging of intact lungs showed that individual survivors undergo rapid clonal expansion and daughter cell dispersal. Individual lineage-labeled AEC2s placed into 3D culture gave rise to self-renewing “alveolospheres,” which contained both AEC2s and cells expressing multiple AEC1 markers, including HOPX, a new marker for AEC1s. Growth and differentiation of the alveolospheres occurred most readily when cocultured with primary PDGFRα+ lung stromal cells. This population included lipofibroblasts that normally reside close to AEC2s and may therefore contribute to a stem cell niche in the murine lung. Results suggest that a similar dynamic exists between AEC2s and mesenchymal cells in the human lung.
Giant Rydberg Excitons in Cuprous Oxide
Creators: name: Kazimierczuk, Tomasz
name: Fröhlich, Dietmar
name: Scheel, Stefan
name: Stolz, Heinrich
name: Bayer, Manfred
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Highly excited atoms with an electron moved into a level with large principal quantum number are fascinating hydrogen-like objects. The giant extension of these Rydberg atoms leads to huge interaction effects. Monitoring these interactions has provided novel insights into molecular and condensed matter physics problems on a single quantum level. Excitons, the fundamental optical excitations in semiconductors consisting of a negatively charged electron and a positively charged hole, are the condensed matter analogues of hydrogen. Highly excited excitons with extensions similar to Rydberg atoms are attractive because they may be placed and moved in a crystal with high precision using microscopic potential landscapes. Their interaction may allow formation of ordered exciton phases or sensing of elementary excitations in the surrounding, also on a quantum level. Here we demonstrate the existence of Rydberg excitons in cuprous oxide, Cu2O, with principal quantum numbers as large as n=25 . These states have giant wave function extensions of more than 2 micrometers, compared to about a nanometer for the ground state. The strong dipole-dipole interaction is evidenced by a blockade effect, where the presence of an exciton prevents excitation of a further exciton in its vicinity.
Self-consistent implementation of locally scaled self-interaction-correction method
Creators: name: Yamamoto, Yoh
name: Baruah, Tunna
name: Chang, Po-Hao
name: Romero, Selim
name: Zope, Rajendra R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Recently proposed local self-interaction correction (LSIC) method [Zope, R. R. et al., J. Chem. Phys. 151, 214108 (2019)] is a one-electron self-interaction-correction (SIC) method that uses an iso-orbital indicator to apply the SIC at each point in space by scaling the exchange-correlation and Coulomb energy densities. The LSIC method is exact for the one-electron densities, also recovers the uniform electron gas limit of the uncorrected density functional approximation, and reduces to the well-known Perdew-Zunger SIC (PZSIC) method as a special case. This article presents the self-consistent implementation of the LSIC method using the ratio of Weizsäcker and Kohn-Sham kinetic energy densities as an iso-orbital indicator. The atomic forces as well as the forces on the Fermi-Löwdin orbitals are also implemented for the LSIC energy functional. Results show that LSIC with the simplest local spin density functional predicts atomization energies of AE6 dataset better than some of the most widely used GGA functional (e.g. PBE) and barrier heights of BH6 database better than some of the most widely used hybrid functionals (e.g. PBE0 and B3LYP). The LSIC method [mean absolute error (MAE) of 0.008 Å] predicts bond lengths of a small set of molecules better than the PZSIC-LSDA (MAE 0.042 Å) and LSDA (0.011 Å). This work shows that accurate results can be obtained from the simplest density functional by removing the self-interaction-errors using an appropriately designed SIC method.
description: 34 pages, 4 figures
A “kiss” before conception: triggering ovulation with kisspeptin-54 may improve IVF
Creators: name: Young, Steven L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A 30-year-old primigravid (G1P000) female with infertility secondary to her partner’s oligospermia and her chronic anovulation presented 13 days after an oocyte retrieval for in vitro fertilization (IVF) with a positive home pregnancy test, abdominal distention, a 5-pound weight gain, nausea, shortness of breath, and reduced urinary frequency. Her IVF cycle included the usual cocktail for gonadotropin stimulation and was uncomplicated, except for excessively stimulated ovaries that led to a peak estradiol level of 6,000 pg/ml and the retrieval of 30 oocytes. Her past history was relevant only for anovulation due to polycystic ovarian syndrome (PCOS), though her preprocedure body mass index was normal at 21 kg/m2. Pelvic ultrasound revealed abundant ascites and enlarged ovaries, at 8 cm average diameter. Serum human chorionic gonadotropin (hCG) concentration was 200 mIU/ml; she was hemoconcentrated (hemoglobin 16 g/dl), with normal liver function and coagulation testing. An ultrasound guided, transvaginal paracentesis removed 4 liters of straw-colored fluid, resulting in significant short-term symptom relief.
Spin-state Gaps and Self-Interaction-Corrected Density Functional Approximations: Octahedral Fe(II) Complexes as Case Study
Creators: name: Romero, Selim
name: Baruah, Tunna
name: Zope, Rajendra R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Accurate prediction of spin-state energy difference is crucial for understanding the spin crossover (SCO) phenomena and is very challenging for the density functional approximations, especially for the local and semi-local approximations, due to delocalization errors. Here, we investigate the effect of self-interaction error removal from the local spin density approximation (LSDA) and PBE generalized gradient approximation (GGA) on the spin-state gaps of Fe(II) complexes with various ligands using recently developed locally scaled self-interaction correction (LSIC) by Zope et al. [J. Chem. Phys. 151, 214108 (2019)]. The LSIC method is exact for one-electron density, which recovers uniform electron gas limit of underlying functional and approaches the well-known Perdew-Zunger self-interaction correction [Phys. Rev. B, 23, 5048 (1981)] (PZSIC) as a special case when the scaling factor is constant. Our results, when compared with reference diffusion Monte Carlo (DMC) results, show that the PZSIC method significantly overestimates spin-state gaps favoring low spin states for all ligands and does not improve upon DFAs. The perturbative LSIC-LSDA using PZSIC densities significantly improves the gaps with a mean absolute error of 0.51 eV but slightly overcorrects for the stronger CO ligands. The quasi-self-consistent LSIC-LSDA, like CCSD(T), gives a correct sign of spin-state gaps for all ligands with MAE of 0.56 eV, comparable to that of CCSD(T) (0.49 eV).
description: 9 pages and 6 figures
An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
Creators: name: Thorp, Edward
name: Herz, Joachim
name: Liu, Kang
name: Farber, Donna L.
name: Subramanian, Manikandan
name: Hayes, Crystal D.
name: Thome, Joseph J.
name: Lakshmana, Madepalli
name: Matsushima, Glenn K.
name: Tabas, Ira
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The phagocytosis of apoptotic cells (ACs), or efferocytosis, by DCs is critical for self-tolerance and host defense. Although many efferocytosis-associated receptors have been described in vitro, the functionality of these receptors in vivo has not been explored in depth. Using a spleen efferocytosis assay and targeted genetic deletion in mice, we identified a multiprotein complex — composed of the receptor tyrosine kinase AXL, LDL receptor–related protein–1 (LRP-1), and RAN-binding protein 9 (RANBP9) — that mediates DC efferocytosis and antigen cross-presentation. We found that AXL bound ACs, but required LRP-1 to trigger internalization, in murine CD8α+ DCs and human-derived DCs. AXL and LRP-1 did not interact directly, but relied on RANBP9, which bound both AXL and LRP-1, to form the complex. In a coculture model of antigen presentation, the AXL/LRP-1/RANBP9 complex was used by DCs to cross-present AC-associated antigens to T cells. Furthermore, in a murine model of herpes simplex virus–1 infection, mice lacking DC-specific LRP-1, AXL, or RANBP9 had increased AC accumulation, defective viral antigen-specific CD8+ T cell activation, enhanced viral load, and decreased survival. The discovery of this multiprotein complex that mediates functionally important DC efferocytosis in vivo may have implications for future studies related to host defense and DC-based vaccines.
Halo nuclei 6He and 8He with the Coulomb-Sturmian basis
Creators: name: Caprio, M. A.
name: Maris, P.
name: Vary, J. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The rapid Gaussian falloff of the oscillator functions at large radius makes them poorly suited for the description of the asymptotic properties of the nuclear wave function, a problem which becomes particularly acute for halo nuclei. We consider an alternative basis for ab initio no-core configuration interaction (NCCI) calculations, built from Coulomb-Sturmian radial functions, allowing for realistic exponential falloff. NCCI calculations are carried out for the neutron halo nuclei 6,8He, as well as the baseline case 4He, with the JISP16 nucleon-nucleon interaction. Estimates are made for the root-mean-square radii of the proton and matter distributions.
description: 13 pages, 8 figures; to be published in Phys. Rev. C
A single photo-electron calibration system for theNectarCAM camera of the Cherenkov Telescope ArrayMedium-Sized Telescopes
Creators: name: Sharma, Pooja
name: Biasuzzi, Barbara
name: Biteau, Jonathan
name: Bourgaux, Martin
name: Caroff, Sami
name: Hull, Giulia
name: Josselin, Michaël
name: Pressard, Kevin
name: Sizun, Patrick
name: Suomijärvi, Tiina
name: Trung, Thi Nguyen
Publisher: name: arXiv
Year: 2021
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: This contribution aims to introduce the single photo-electron system designed to calibrate the camera of the Medium-Sized Telescopes of the Cherenkov Telescope Array (CTA). This system will allow us to measure accurately the gain of the camera's photodetection chain and to constrain the systematic uncertainties on the energy reconstruction of gamma rays detected by CTA. The system consists of a white painted screen, a fishtail light guide, a flasher and an XY motorization to allow movement. The flashes guided by the fishtail mimic the Cherenkov radiation and illuminate the focal plane under the screen homogeneously. Then, through the XY motorisation, the screen is moved across the entire focal plane of the NectarCAM camera, which consists of 1855 photo-multiplier tubes. In this contribution, we present the calibration system and the study on its optimum scan positions required to cover the full camera effectively. Finally, we illustrate the results of the calibration data analysis and discuss the performance of the system.
New physics in $WWγ$ at one loop via Majorana neutrinos
Creators: name: Martínez, Eduardo
name: Montaño-Domínguez, Javier
name: Novales-Sánchez, Héctor
name: Salinas, Mónica
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Current experimental data guarantees the presence of physics beyond the Standard Model in the neutrino sector. The responsible physical description might show itself through virtual effects on low-energy observables. In particular, massive neutrinos are able to produce contributions to the triple gauge coupling $WWγ$. The present paper deals with the calculation, estimation and analysis of one-loop contributions from Majorana neutrinos to the Lorentz-covariant $WWγ$ parametrization. Our calculations show that CP-odd effects vanish exactly, whereas CP-even contributions, $Δκ$ and $ΔQ$, remain. According to our estimations, the effects from heavy neutrinos with masses in the range of hundreds of GeVs dominate over those from light neutrinos. This investigation shows that contributions from heavy Majorana neutrinos to the anomaly $Δκ$ could be as large as $\sim{\cal O}(10^{-3})$, one order of magnitude below the Standard-Model contribution. We find that the International Linear Collider, sensitive to triple gauge couplings participating in $WW$ production, might measure these effects in electron-positron collisions at a center-of-mass energy of $800\,{\rm GeV}$, as long as heavy-neutrino masses are $\gtrsim300\,{\rm GeV}$ and below $\sim1500\,{\rm GeV}$.
description: Accepted by Physical Review D for publication, 16 pages, 4 figures
CD45 ligation expands Tregs by promoting interactions with DCs
Creators: name: Lu, Yuning
name: Wan, Yisong Y.
name: Shlomchik, Warren D.
name: Farber, Donna L.
name: Flavell, Richard A.
name: Lakkis, Fadi G.
name: Guz, Galip
name: Wang, Ying
name: Rothstein, David M.
name: Finn, Patricia W.
name: Deng, Songyan
name: Perkins, David L.
name: Lin, Yan
name: Rudd, Christopher E.
name: Camirand, Geoffrey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. Consequently, methods to expand Tregs for therapeutic use are of great interest. While transfer of Tregs after massive ex vivo expansion can be achieved, in vivo expansion of Tregs would be more practical. Here, we demonstrate that targeting the CD45 tyrosine phosphatase with a tolerogenic anti-CD45RB mAb acutely increases Treg numbers in WT mice, even in absence of exogenous antigen. Treg expansion occurred through substantial augmentation of homeostatic proliferation in the preexisting Treg population. Moreover, anti-CD45RB specifically increased Treg proliferation in response to cognate antigen. Compared with conventional T cells, Tregs differentially regulate their conjugation with DCs. Therefore, we determined whether CD45 ligation could alter interactions between Tregs and DCs. Live imaging showed that CD45 ligation specifically reduced Treg motility in an integrin-dependent manner, resulting in enhanced interactions between Tregs and DCs in vivo. Increased conjugate formation, in turn, augmented nuclear translocation of nuclear factor of activated T cells (NFAT) and Treg proliferation. Together, these results demonstrate that Treg peripheral homeostasis can be specifically modulated in vivo to promote Treg expansion and tolerance by increasing conjugation between Tregs and DCs.
Trap-loss spectroscopy of Rydberg states in ytterbium
Creators: name: Halter, Christian
name: Miethke, Alexander
name: Sillus, Christian
name: Hegde, Apoorva
name: Goerlitz, Axel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We present an experimental study of the Rydberg $^1S_0$- and $^1P_1$- series of ytterbium for principal quantum numbers in the range of $n=70$ to $90$. The study is performed using trap loss spectroscopy in a magneto-optical trap operating on the $6^1S_0 \rightarrow 6^1P_1$ transition at $399\,\text{nm}$. Compared to the commonly used Rydberg spectroscopy method using field-ionization and ion detection, trap loss spectroscopy is significantly simpler and requires a less sophisticated experimental setup. Using this method we determine relative values of the scalar and tensor electric polarizabilities of both, $6sns\,^1S_0$- and $6snp\,^1P_1$- Rydberg states.
Decarbonizing Sweden’s energy and transportation system by 2050
Creators: name: Bramstoft, Rasmus
name: Skytte, Klaus
Publisher: name: International Journal of Sustainable Energy Planning and Management
Year: 2018

description: Decarbonizing Sweden’s transportation sector is necessary to realize its long-term vision of eliminating net greenhouse gas (GHG) emissions from the energy system by 2050. Within this context, this study develops two scenarios for the transportation sector: one with high electrification (EVS) and the other with high biofuel and biomethane utilization (BIOS). The energy system model STREAM is utilized to compute the socioeconomic system cost and simulate an integrated transportation, electricity, gas, fuel refinery, and heat system. The results show that electrifying a high share of Sweden’s road transportation yields the least systems cost. However, in the least-cost scenario (EVS), bioenergy resources account for 57% of the final energy use in the transportation sector. Further, a sensitivity analysis shows that the costs of different types of cars are the most sensitive parameters in the comparative analysis of the scenarios.
description: International Journal of Sustainable Energy Planning and Management, Vol 14 (2017)
Face-centered cubic crystallization of atomistic configurations
Creators: name: Flatley, Lisa
name: Theil, Florian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We address the question of whether three-dimensional crystals are minimizers of classical many-body energies. This problem is of conceptual relevance as it presents a significant milestone towards understanding, on the atomistic level, phenomena such as melting or plastic behavior. We characterize a set of rotation- and translation-invariant two- and three-body energies such that the energy minimum per particle over all n-particle configurations converges to the energy per particle in the face-centered cubic (fcc) lattice as tends to infinity. The proof involves a careful analysis of the symmetry properties of the fcc lattice.
Giant efficiency of long-range orbital torque in Co/Nb bilayers
Creators: name: Liu, Fufu
name: Liang, Bokai
name: Xu, Jie
name: Jia, Chenglong
name: Jiang, Changjun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We report unambiguously experimental evidence of a strong orbital current in Nb films with weak spin-orbit coupling via the spin-torque ferromagnetic resonance (ST-FMR) spectrum for Fe/Nb and Co/Nb bilayers. The sign change of the damping-like torque in Co/Nb demonstrates a large spin-orbit correlation and thus great efficiency of orbital torque in Co/Nb. By studying the efficiency as a function of the thickness of Nb sublayer, we reveal a long orbital diffusion length (~3.1 nm) of Nb. Further planar Hall resistance (PHE) measurements at positive and negative applying current confirm the nonlocal orbital transport in ferromagnetic-metal/Nb heterostructures.
StarDICE I: sensor calibration bench and absolute photometric calibration of a Sony IMX411 sensor
Creators: name: Betoule, Marc
name: Antier, Sarah
name: Bertin, Emmanuel
name: Blanc, Pierre Éric
name: Bongard, Sébastien
name: Tanugi, Johann Cohen
name: Dagoret-Campagne, Sylvie
name: Feinstein, Fabrice
name: Hardin, Delphine
name: Juramy, Claire
name: Guillou, Laurent Le
name: Van Suu, Auguste Le
name: Moniez, Marc
name: Neveu, Jérémy
name: Nuss, Éric
name: Plez, Bertrand
name: Regnault, Nicolas
name: Sepulveda, Eduardo
name: Sommer, Kélian
name: Souverin, Thierry
name: Wang, Xiao Feng
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Hubble diagram of type-Ia supernovae (SNe-Ia) provides cosmological constraints on the nature of dark energy with an accuracy limited by the flux calibration of currently available spectrophotometric standards. The StarDICE experiment aims at establishing a 5-stage metrology chain from NIST photodiodes to stars, with a targeted accuracy of \SI{1}{mmag} in $griz$ colors. We present the first two stages, resulting in the calibration transfer from NIST photodiodes to a demonstration \SI{150}{Mpixel} CMOS sensor (Sony IMX411ALR as implemented in the QHY411M camera by QHYCCD). As a side-product, we provide full characterization of this camera. A fully automated spectrophotometric bench is built to perform the calibration transfer. The sensor readout electronics is studied using thousands of flat-field images from which we derive stability, high resolution photon transfer curves and estimates of the individual pixel gain. The sensor quantum efficiency is then measured relative to a NIST-calibrated photodiode. Flat-field scans at 16 different wavelengths are used to build maps of the sensor response. We demonstrate statistical uncertainty on quantum efficiency below \SI{0.001}{e^-/γ} between \SI{387}{nm} and \SI{950}{nm}. Systematic uncertainties in the bench optics are controlled at the level of \SI{1e-3}{e^-/γ}. Uncertainty in the overall normalization of the QE curve is 1\%. Regarding the camera we demonstrate stability in steady state conditions at the level of \SI{32.5}{ppm}. Homogeneity in the response is below \SI{1}{\percent} RMS across the entire sensor area. Quantum efficiency stays above \SI{50}{\percent} in most of the visible range, peaking well above \SI{80}{\percent} between \SI{440}{nm} and \SI{570}{nm}. Differential non-linearities at the level of \SI{1}{\percent} are detected. A simple 2-parameter model is proposed to mitigate the effect.
description: accepted for publication in A&A, correct author list
Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure
Creators: name: Matsui, Hiro
name: Button, Brian
name: Leigh, Margaret W.
name: Kesimer, Mehmet
name: Sheehan, John K.
name: Cai, Li-Heng
name: Davis, C. William
name: Henderson, Ashley G.
name: DeMaria, Genevieve C.
name: Ehre, Camille
name: Donaldson, Scott H.
name: Abdullah, Lubna H.
name: Boucher, Richard C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow depends on the relative mucin concentration of the mucus layer compared with that of the periciliary layer; however, mucin concentrations have been difficult to measure in CF secretions. Here, we have shown that the concentration of mucin in CF sputum is low when measured by immunologically based techniques, and mass spectrometric analyses of CF mucins revealed mucin cleavage at antibody recognition sites. Using physical size exclusion chromatography/differential refractometry (SEC/dRI) techniques, we determined that mucin concentrations in CF secretions were higher than those in normal secretions. Measurements of partial osmotic pressures revealed that the partial osmotic pressure of CF sputum and the retained mucus in excised CF lungs were substantially greater than the partial osmotic pressure of normal secretions. Our data reveal that mucin concentration cannot be accurately measured immunologically in proteolytically active CF secretions; mucins are hyperconcentrated in CF secretions; and CF secretion osmotic pressures predict mucus layer–dependent osmotic compression of the periciliary liquid layer in CF lungs. Consequently, mucin hypersecretion likely produces mucus stasis, which contributes to key infectious and inflammatory components of CF lung disease.
Energy Use: Electricity System in West Africa and Climate Change Impact
Creators: name: Momodu, Abiodun Suleiman
Publisher: name: International Journal of Sustainable Energy Planning and Management
Year: 2018

description: This article investigates a low carbon pathway, the theoretical frame for understanding the trade-offs between economic development and climate change. An already developed model - Electricity Planning-Low Carbon Development (EP-LCD) - was adapted and modified to examine the nonlinear relationship between generation adequacy and greenhouse gas (GHG) emission reduction for better targeted strategic regional intervention on climate change. Two broad scenarios - Base and LCD Option - were tested for the West African Power Pool (WAPP). The cost impact of increasing generation capacity in the LCD Option was estimated at US$1.54 trillion over a 50 year period. Achieving the goal of low carbon pathway would be largely influenced by government decision. Four strategies, in line with the Nationally Determined Contribution in Paris Agreement, were recommended. These are: a) enforced improved efficient electricity generation through increased energy efficiency that should result in increased capacity factor; b) decreased energy intensity of economic activities to result in reduced emission factor in existing plants; c) attract new investment through low tax or tax exemption to reduce cost of constructing power plants for the benefit of base-load plants; and d) subsidized cost of low-carbon fuels in the short run to benefit intermediate load plants and allow for the ramping up of low-/no-carbon fuel generation capacity. These are recommended considering the region’s specific economical and political conditions where funds are tremendously difficult to raise. Implementing these recommendations will allow the electric power industry in West Africa to contribute to achieving sustainable development path.
description: International Journal of Sustainable Energy Planning and Management, Vol 14 (2017)
From Elastic Spin to Phonon Spin: Symmetry and Fundamental Relations
Creators: name: Ren, Jie
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: This work is mainly based on postgraduate lectures at Tongji University since 2020 spring. We firstly revisit the elastic spin and orbital angular momentum [Proc. Natl. Acad. Sci. USA 115, 9951 (2018)] but more general for anisotropic systems by applying Noether's theorem to the elastic Lagrangian and by applying the symmetry argument in the field theory. Then, fundamental relations between elastic energy flux and elastic spin are uncovered. In particular cases, the wave spin is closely related to the vorticity of energy flux and momentum. Secondly, we move forward from the elastic spin to revisit the phonon spin [Fizika Tverdogo Tela 3, 2160 (1961)] by applying the second quantization to elastic fields. We show that the uncovered phonon spin, a polarized elastic-vibration quanta, is generally not restricted to transverse phonon modes, but applying to general phonon modes, such as the longitudinal phonon modes, surface phonon modes, and hybridized phonon modes, regarded as a consequence of mode interferences. The elastic spin and phonon spin originate from the local rotating of the field polarization in time domain, not the local circulation (vorticity) of displacement or velocity in space domain. It is hopeful that the present results could advance the fundamental understanding of phonon spin and elastic spin, and promote the spin phononics for hybrid quantum sensing and technology with multiple degrees of freedom.
description: 9 pages
Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution
Creators: name: Lim, Jiyeon
name: Brantley-Sieders, Dana M.
name: Vaught, David B.
name: Williams, Andrew
name: Williams, Michelle
name: Cook, Rebecca S.
name: Tonetti, Debra
name: Stanford, Jamie C.
name: Morrison, Meghan M.
name: Young, Christian
name: Hicks, Donna
name: Earp, H. Shelton
name: Owens, Philip
name: Balko, Justin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Breast cancers that occur in women 2–5 years postpartum are more frequently diagnosed at metastatic stages and correlate with poorer outcomes compared with breast cancers diagnosed in young, premenopausal women. The molecular mechanisms underlying the malignant severity associated with postpartum breast cancers (ppBCs) are unclear but relate to stromal wound-healing events during postpartum involution, a dynamic process characterized by widespread cell death in milk-producing mammary epithelial cells (MECs). Using both spontaneous and allografted mammary tumors in fully immune–competent mice, we discovered that postpartum involution increases mammary tumor metastasis. Cell death was widespread, not only occurring in MECs but also in tumor epithelium. Dying tumor cells were cleared through receptor tyrosine kinase MerTK–dependent efferocytosis, which robustly induced the transcription of genes encoding wound-healing cytokines, including IL-4, IL-10, IL-13, and TGF-β. Animals lacking MerTK and animals treated with a MerTK inhibitor exhibited impaired efferocytosis in postpartum tumors, a reduction of M2-like macrophages but no change in total macrophage levels, decreased TGF-β expression, and a reduction of postpartum tumor metastasis that was similar to the metastasis frequencies observed in nulliparous mice. Moreover, TGF-β blockade reduced postpartum tumor metastasis. These data suggest that widespread cell death during postpartum involution triggers efferocytosis-induced wound-healing cytokines in the tumor microenvironment that promote metastatic tumor progression.
Introducing Fermionic Link Models
Creators: name: Banerjee, Debasish
name: Huffman, Emilie
name: Rammelmüller, Lukas
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Quantum link models (QLMs) are extensions of Wilson-type lattice gauge theories, and show rich physics beyond the phenomena of conventional Wilson gauge theories. Here we explore the physics of $U(1)$ symmetric QLMs, both using a more conventional quantum spin-1/2 representation, as well as a fermionic representation. In 2D, we show that both bosonic and fermionic QLMs display the same physics. We then explore the models in 3D and find different behavior for the two QLMs. For the bosons, we see evidence for a quantum phase transition from a symmetry broken phase to a potential quantum spin liquid phase. For the fermions, we identify not one but two distinct phases in addition to a symmetry broken phase. We explore the symmetries of the ground state in the strong coupling limit, which breaks lattice symmetries and examine the spectrum for both models.
description: 9 pages, 5 figures, contribution to the 38th International Symposium on Lattice Field Theory (LATTICE21)
Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal
Creators: name: Kim, William Y.
name: Levine, Ross L.
name: Troester, Melissa A.
name: Lee, Cleo Y.
name: Clark, Kelly
name: Jeong, Youngtae
name: Bailey, Sean T.
name: Diehn, Maximilian
name: Perou, Charles M.
name: Darr, David
name: Murphy, Laura
name: Damrauer, Jeffrey S.
name: Fan, Cheng
name: Miller, C. Ryan
name: Hadzic, Tanja
name: Jin, Jian
name: Zhou, Bing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Erythropoietin (EPO) is a hormone that induces red blood cell production. In its recombinant form, EPO is the one of most prescribed drugs to treat anemia, including that arising in cancer patients. In randomized trials, EPO administration to cancer patients has been associated with decreased survival. Here, we investigated the impact of EPO modulation on tumorigenesis. Using genetically engineered mouse models of breast cancer, we found that EPO promoted tumorigenesis by activating JAK/STAT signaling in breast tumor-initiating cells (TICs) and promoted TIC self renewal. We determined that EPO was induced by hypoxia in breast cancer cell lines, but not in human mammary epithelial cells. Additionally, we demonstrated that high levels of endogenous EPO gene expression correlated with shortened relapse-free survival and that pharmacologic JAK2 inhibition was synergistic with chemotherapy for tumor growth inhibition in vivo. These data define an active role for endogenous EPO in breast cancer progression and breast TIC self-renewal and reveal a potential application of EPO pathway inhibition in breast cancer therapy.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (72 a)]
Creators: name: , Margarita
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1431
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Margarita, Tochter des verstorbenen Abraminus de Monestirolo, Witwe des Laurentius de Foliatis und Mutter der etwa vierjährigen Johanna de Foliatis und des etwa zweijährigen Abraminus de Foliatis, beide Kinder des genannten Laurentius, aus der Nachbarschaft St. Vitalis in Cremona ersucht in Gegenwart des Petrus de Tronamalis, Rechtsgelehrter, iudex maleficiorum und Stellvertreter des Gratius de Gentilibus, seinerseits Rechtsgelehrter, vicarius und iudex rationis des Podestà Petrus de Raymondis von Cremona, um ihre Einsetzung als Vormund der genannten Kinder. Es folgt ein weiterer Rechtsakt, in dem Petrus der Bitte Margaritas entspricht.
Factor XIII activity mediates red blood cell retention in venous thrombi
Creators: name: Lam, Wilbur A.
name: Byrnes, James R.
name: Degen, Jay L.
name: Mackman, Nigel
name: Flick, Matthew J.
name: Aleman, Maria M.
name: Wang, Jian-Guo
name: Wolberg, Alisa S.
name: Di Paola, Jorge
name: Tran, Reginald
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Venous thrombi, fibrin- and rbc-rich clots triggered by inflammation and blood stasis, underlie devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition, rbc are thought to become passively trapped in thrombi and therefore have not been considered a modifiable thrombus component. In the present study, we determined that activity of the transglutaminase factor XIII (FXIII) is critical for rbc retention within clots and directly affects thrombus size. Compared with WT mice, mice carrying a homozygous mutation in the fibrinogen γ chain (Fibγ390–396A) had a striking 50% reduction in thrombus weight due to reduced rbc content. Fibrinogen from mice harboring the Fibγ390–396A mutation exhibited reduced binding to FXIII, and plasma from these mice exhibited delayed FXIII activation and fibrin crosslinking, indicating these residues mediate FXIII binding and activation. FXIII-deficient mice phenocopied mice carrying Fibγ390–396A and produced smaller thrombi with fewer rbc than WT mice. Importantly, FXIII-deficient human clots also exhibited reduced rbc retention. The addition of FXIII to FXIII-deficient clots increased rbc retention, while inhibition of FXIII activity in normal blood reduced rbc retention and produced smaller clots. These findings establish the FXIII-fibrinogen axis as a central determinant in venous thrombogenesis and identify FXIII as a potential therapeutic target for limiting venous thrombosis.