Disposition of <i>tris</i>(4-chlorophenyl)methanol and <i>tris</i>(4-chlorophenyl)methane in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration
Creators: name: Catlin, Natasha R.
name: Suramya Waidyanatha
name: Black, Sherry R.
name: Mathews, James M.
name: Snyder, Rodney W.
name: Purvi R. Patel
name: Watson, Scott L.
name: Fennell, Timothy R.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: FOS: Physical sciences
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: <i>Tris</i>(4-chlorophenyl)methane (TCPME) and <i>tris</i>(4-chlorophenyl)methanol (TCPMOH) have been detected in various biota and human tissues.The current studies were undertaken to investigate the disposition and metabolism of TCPME and TCPMOH in rats and mice.[<sup>14</sup>C]TCPME was well absorbed (≥66%) in male rats and mice following a single oral administration of 1, 10, or 100 mg/kg. The excretion of [<sup>14</sup>C]TCPME-derived radioactivity in urine (≤2.5%) and feces (≤18%) was low. The administered dose was retained in tissues (≥ 64%) with adipose containing the highest concentrations. The metabolism of TCPME was minimal. The disposition and metabolism of [<sup>14</sup>C]TCPME in females was similar to males.The time to reach maximum concentration was ≤7 h, the plasma elimination half-life was ≥31 h, and the bioavailability was ≥82% following a 10 mg/kg oral dose of [<sup>14</sup>C]TCPME in male rats and mice.The disposition of [<sup>14</sup>C]TCPMOH was similar to that of [<sup>14</sup>C]TCPME.Following an intravenous administration of [<sup>14</sup>C]TCPME or [<sup>14</sup>C]TCPMOH in male rats and mice, the pattern of disposition was similar to that of oral administration.In conclusion, both TCPME and TCPMOH are readily absorbed and highly bioavailable following a single oral administration pointing to importance of assessing the toxicity of these chemicals. <i>Tris</i>(4-chlorophenyl)methane (TCPME) and <i>tris</i>(4-chlorophenyl)methanol (TCPMOH) have been detected in various biota and human tissues. The current studies were undertaken to investigate the disposition and metabolism of TCPME and TCPMOH in rats and mice. [<sup>14</sup>C]TCPME was well absorbed (≥66%) in male rats and mice following a single oral administration of 1, 10, or 100 mg/kg. The excretion of [<sup>14</sup>C]TCPME-derived radioactivity in urine (≤2.5%) and feces (≤18%) was low. The administered dose was retained in tissues (≥ 64%) with adipose containing the highest concentrations. The metabolism of TCPME was minimal. The disposition and metabolism of [<sup>14</sup>C]TCPME in females was similar to males. The time to reach maximum concentration was ≤7 h, the plasma elimination half-life was ≥31 h, and the bioavailability was ≥82% following a 10 mg/kg oral dose of [<sup>14</sup>C]TCPME in male rats and mice. The disposition of [<sup>14</sup>C]TCPMOH was similar to that of [<sup>14</sup>C]TCPME. Following an intravenous administration of [<sup>14</sup>C]TCPME or [<sup>14</sup>C]TCPMOH in male rats and mice, the pattern of disposition was similar to that of oral administration. In conclusion, both TCPME and TCPMOH are readily absorbed and highly bioavailable following a single oral administration pointing to importance of assessing the toxicity of these chemicals.