cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The repertoire of iron superoxide dismutases from Leishmania infantum as targets in the search for therapeutic agents against leishmaniasis
Creators: name: García-Soriano, Juan Carlos
name: de Lucio, Héctor
name: Elvira-Blázquez, Daniel
name: Alcón-Calderón, Mercedes
name: del Olmo, Natalia Sanz
name: Sánchez-Murcia, Pedro A.
name: Ortega, Paula
name: de la Mata, Francisco Javier
name: Jiménez-Ruiz, Antonio
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: Species of Leishmania and Trypanosoma genera are the causative agents of relevant parasitic diseases. Survival inside their hosts requires the existence of a potent antioxidant enzymatic machinery. Four iron superoxide dismutases have been described in trypanosomatids (FeSODA, FeSODB1, FeSODB2, and FeSODC) that hold a potential as therapeutic targets. Nonetheless, very few studies have been developed that make use of the purified enzymes. Moreover, FeSODC remains uncharacterised in Leishmania. In this work, for the first time, we describe the purification and enzymatic activity of recombinant versions of the four Leishmania FeSOD isoforms and establish an improved strategy for developing inhibitors. We propose a novel parameter [(V*cyt. c − Vcyt. c)/Vcyt. c] which, in contrast to that used in the classical cytochrome c reduction assay, correlates linearly with enzyme concentration. As a proof of concept, we determine the IC50 values of two ruthenium carbosilane metallodendrimers against these isoforms.
Robotic timber construction : Expanding additive fabrication to new dimensions
Creators: name: Willmann, Jan
name: Knauss, Michael
name: Bonwetsch, Tobias
name: Apolinarska, Anna Aleksandra
name: Gramazio, Fabio
name: Kohler, Matthias
Year: 2016

description: This paper presents a novel approach to non-standard timber assembly – Robotic Timber Construction (RTC) – where robotic fabrication is used to expand additive digital fabrication techniques towards industrial full scale dimensions. Featuring robotic systems that grasp, manipulate, and finally position building components according to a precise digital blueprint, RTC combines robotic assembly procedures and advanced digital design of non-standard timber structures. The resulting architectural morphologies allow for a convergence of aesthetic and functional concerns, enabling structural optimisation through the locally differentiated aggregation of material. Initiated by the group of Gramazio Kohler Research at ETH Zurich, this approach offers a new perspective on automated timber construction, where the focus is shifted from the processing of single parts towards the assembly of generic members in space. As such, RTC promotes unique advantages over conventional approaches to timber construction, such as, for example, CNC joinery and cutting: through the automated placement of material exactly where it is needed, RTC combines additive and largely waste-free construction with economic assembly procedures, it does not require additional external building reference, and it offers digital control across the entire building process, even when the design and assembly information are highly complex. This paper considers 1) research parameters for the individual components of RTC (such as computational design processes, construction methods and fabrication strategies), and 2) the architectural implications of integrating these components into a systemic, unifying process at the earliest stages of design. Overall, RTC leads to profound changes in the design, performance and expressive language of architecture and thus fosters the creation of architecture that profoundly reinvents its constructive repertoire.
Additional file 3: Table S3. of Identification of three new isolates of Tomato spotted wilt virus from different hosts in China: molecular diversity, phylogenetic and recombination analyses
Creators: name: Zhenjia Zhang
name: Deya Wang
name: Chengming Yu
name: Zenghui Wang
name: Jiahong Dong
name: Kerong Shi
name: Xuefeng Yuan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Summary of recombination events in different full-length TSWV L isolates using RDP4. NS: not significant. (DOCX 31Â kb)
Enhanced Recovery after Surgery (ERAS). Wie erleben Patientinnen und Patienten den Einbezug in die Pflege? Eine qualitative Perspektive
Creators: name: Bernet, Madeleine
name: Lipp, Iris
name: Zürcher, Sabin
name: Furler, Laura
name: Sommerhalder, Kathrin
name: Soom Ammann, Eva
Publisher: name: pflegenetz
Year: 2018

description: Enhanced Recovery after Surgery (ERAS) ist ein standardisiertes chirurgisches Behandlungsprogramm. Patientinnen und Patienten wird darin eine aktive Rolle in ihrem Genesungsprozess übertragen. Die Patientinnenund Patientenedukation gehört dabei zu den zentralen pflegerischen Aufgaben. Wie Betroffene das ERAS-Programm erleben, wurde in einer Klinik in der Schweiz anhand einer qualitativen Längsschnittstudie untersucht. Es wurden 15 Patientinnen und fünf Patienten im Alter zwischen 20 und 85 Jahren interviewt. Die Datenanalyse erfolgte mittels interpretativer phänomenologischer Analyse (IPA). Dieser phänomenologisch orientierte Ansatz zielt darauf ab, die persönlichen Erfahrungen von Menschen und deren Bedeutung für sie zu erklären. Die Ergebnisse zeigen, dass aus Patientinnen und Patientensicht durch eine partnerschaftliche und kontinuierliche Kommunikation, welche wiederum Vertrauen, Sicherheit und genügend Zeitfenster für Gespräche vermittelt, die Partizipation innerhalb von ERAS gefördert werden kann. Schlüsselbegriffe: ERAS, Partizipation, qualitative Forschung
Additional file 5: of The impact of taphonomic data on phylogenetic resolution: Helenodora inopinata (Carboniferous, Mazon Creek LagerstĂ¤tte) and the onychophoran stem lineage
Creators: name: Murdock, Duncan
name: Gabbott, Sarah
name: Purnell, Mark
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Amended panarthropod phylogeny with synapomorphies mapped onto consensus tree topology. Upper topology derived from modifying the character coding for Helenodora inopinata (=Ilyodes) of Yang et al. [4] to reflect the new observations herein. Lower topology derived in the same way but with characters whose absence is inferred from taphonomic analysis coded as ambiguous. For details of how trees were generated see Methods and caption of fig.Â 8. Upper numbers refer to character number and lower (bracketed) numbers refer to character state, both from analysis of Yang et al. [4]. Grey boxes indicate synapomorphies not present in all trees used to draw the consensus. (PDF 369 kb)
Additional file 1: of Immunogenicity and safety of intradermal influenza vaccine in immunocompromized patients: a meta-analysis of randomized controlled trials
Creators: name: Pileggi, Claudia
name: Lotito, Francesca
name: Bianco, Aida
name: Nobile, Carmelo
name: Pavia, Maria
Publisher: name: Figshare
Year: 2015
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: PRISMA checklist. (DOC 69Â kb)
3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents
Creators: name: Wang, Chao
name: Zhang, Yujing
name: Yang, Shanbo
name: Shi, Lingyu
name: Xiu, Yutao
name: Wu, Yudong
name: Jiang, Hongfei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology

description: A series of cis-restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking. Compound 9p, exhibited potent antiproliferative activity against HeLa, MCF-7, and A549 cell lines. Mechanism studies indicated that 9p potently inhibited tubulin polymerisation and disrupted the microtubule dynamics of tubulin in HeLa cells. Moreover, 9p could cause G2/M phase cell cycle arrest and apoptosis in HeLa cells. In addition, the prediction of physicochemical properties disclosed that 9p conformed well to the Lipinski’s rule of five. The initial results suggest that the 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines could serve as a promising scaffold for the development of novel anticancer drugs.
Hydrobaenus Fries 1830
Creators: name: Makarchenko, Eugenyi A.
name: Makarchenko, Marina A.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Hydrobaenus

description: Hydrobaenus Fries, 1830: 177.
Hydrobaenus Fries; Saether 1976: 54; Cranston et al. 1983: 175, 1989: 204; Coffman et al. 1986: 181; Sasa & Kikuchi 1995: 164; Makarchenko & Makarchenko 2006b: 319, 501, 646; Ashe & O'Connor 2012: 311; Andersen et al. 2013: 226.
Type species: Hydrobaenus lugubris Fries, 1830, by original designation. Senior homonym of Hydrobaenus Fries, 1831.
Generic diagnosis (emended). Based on a new Far-Eastern material and references by Cranston et al. (2007); Makarchenko et al. (2009); Makarchenko & Makarchenko (2010, 2011, 2012); Zerguine & Rossaro (2010), the generic diagnosis given by Saether (1976), Cranston et al. (1983, 1989), Coffman et al. (1986) and Andersen et al. (2013) should be emended as follows:
Adult male. Acrostichals absent or present, when present, then weak and short, not strong decumbent, beginning close to antepronotum or some distance from antepronotum, or situated only in middle part of scutum. Pseudospurs present on tarsomere 1 and often tarsomere 2 of mid and hind legs, occasionally absent. Virga consisting of a cluster of few spines or absent. Oral projections of transverse sternapodeme pointed, rod-shaped or roundish triangular. Gonostylus with one or rarely several megasetae.
Pupa. Tergite II with posterior hooklets or with posterior group of simple spinules with apex pointed orally. Pedes spurii A present on sternites IV–VI or IV–VIII, occasionally absent. Segment I with 1–3 L setae from one side; segment II with 3–4 L setae; segments III–VI each with 4 L setae 0–1 of them taeniate on IV, 0–2 taeniate on V, 0–4 taeniate on VI; segment VII with 3 or usually, 4 L setae, 0–4 of them taeniate; segment VIII usually with 4– 5 taeniate L setae, sometimes with 4 strong simple L setae. Anal lobe usually with 3, occasionally with 6–7 anal macrosetae and with full to reduced fringe of short setae or sometimes without fringe. Male genital sac ending near or extending beyond of anal lobe, with or without of short apical projection or protuberance.
Larva. Antenna with 5–6 segments; if antenna with 6 segments, the sixth segment vestigial. S I plumose or sometimes palmate. Mentum with 1–2 median and 6 pairs of lateral teeth or sometimes with 2 median and 5 pairs of lateral teeth.
description: Published as part of Makarchenko, Eugenyi A. & Makarchenko, Marina A., 2014, On taxonomy of Hydrobaenus Fries, 1830 (Diptera: Chironomidae: Orthocladiinae) from the Russian Far East, with a key to species, pp. 429-438 in Zootaxa 3760 (3) on page 430, DOI: 10.11646/zootaxa.3760.3.9, http://zenodo.org/record/231006
Additional file 3: of The impact of taphonomic data on phylogenetic resolution: Helenodora inopinata (Carboniferous, Mazon Creek LagerstĂ¤tte) and the onychophoran stem lineage
Creators: name: Murdock, Duncan
name: Gabbott, Sarah
name: Purnell, Mark
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Full resolution versions of images presented in Fig.Â  3a,c . RGB levels have been adjusted to better show the fossils, in some cases only in the region of the nodule that bears the fossil. For further details see caption at Fig.Â 3. (PDF 53604 kb)
Faustschlusskraft: Nützliches Tool - selten angewendet
Creators: name: Kurmann, Silvia
name: Uhlmann, Katja
name: Galli, Livia
name: Steiner, Nina
Publisher: name: Rosenfluh
Year: 2020

description: Mit der Faustschlusskraft (FSK) lässt sich die Muskelfunktion erfassen. Es wird angenommen, dass die Verringerung der Muskelfunktion im katabolen Stoffwechsel nicht nur von der Muskelmasse abhängig ist, sondern von weiteren Parametern wie beispielsweise dem Elektrolytstatus oder dem Membranpotenzial. Das macht die FSK als frühen und sensiblen Indikator einer katabolen Stoffwechsellage interessant.
Результаты испытаний сортов гречихи в Швейцарии
Results of variety trials with buckwheat in Switzerland
Creators: name: Luginbühl, C.
name: Strahm, S.
name: Ramseier, Hans
name: Füglistaller, Dominik
name: Hiltbrunner, J.
Publisher: name: ФГБНУ Федеральный научный центр зернобобовых и крупяных культур
Year: 2018
Subjects: buckwheat
Fagopyrum esculentum Moench
variety testing
determinate growth
grain yield
Switzerland

description: Выращивание гречихи (Fagopyrum esculentum Moench) имело давнюю традицию в Швейцарии, которая исчезла в XX веке. В течение нескольких последних лет интерес к гречихе вновь возрос, и среди прочего, необходимо было найти сорта, адаптированные к климатическим условиям страны. Поэтому в 2014 году швейцарская сельскохозяйственная научно-исследовательская станция Agroscope начала полевые испытания с различными сортами гречихи. Среди тестируемых сортов было пять с детерминантным типом роста российской селекции из ФГБНУ ВНИИЗБК. Испытания 14 сортов гречихи были проведены в двух точках (Цюрих и Цолликофен) в 2016 году. Урожайность зерна колебалась от 1,57 т/га (Drollet) до 3,38 т/га (Дружина). Влажность зерна при уборке урожая у российских сортов варьировала от 13,6% до 18% в Цюрихе и от 27% до 29,1% в Цолликофене. Возможность с помощью новых сортов гречихи начать успешное производство швейцарских продуктов из гречихи зависит от потребителя, а также от возможностей переработки зерна гречихи (то есть обрушивания) и разработки других продуктов из гречихи кроме муки.
description: Growing buckwheat (Fagopyrum esculentum Moench) had a long tradition in Switzerland which disappeared in the 20th century. Since a few years interest in buckwheat increased again and among others also varieties adapted to the climatic conditions had to be found. Therefore Agroscope, the Swiss Agricultural Research station, initiated field trials with different buckwheat varieties in 2014. Among the tested varieties there were also five with a determinate growth from a Russian breeding program. Trials at two sites (Zurich and Zollikofen) with 14 varieties have been conducted in 2016. Grain yields varied from 15.7 dt/ha (Drollet) up to 33.8 dt/ha (Drushina). The water content of the Russian varieties at harvest varied between 13.6 % and 18 % at Zurich and 27 % and 29.1 % at Zollikofen. In order to confirm results, trials should be repeated again in 2017. Whether with new buckwheat varieties a successful Swiss buckwheat production can be initiated depends on one side on the consumer but also on possibilities of the processing of buckwheat grains (i.e. dehulling) and the development of other buckwheat products than flour.
Additional file 1: Table S1. of Identification of three new isolates of Tomato spotted wilt virus from different hosts in China: molecular diversity, phylogenetic and recombination analyses
Creators: name: Zhenjia Zhang
name: Deya Wang
name: Chengming Yu
name: Zenghui Wang
name: Jiahong Dong
name: Kerong Shi
name: Xuefeng Yuan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 60506 Virology

description: TSWV isolates used in this study. TSWV isolates from different countries use different abbreviations as followed, China (CL, CM and CS), South Korea (KL, KM and KS), Japan (JL, JM, JS), USA (UL, UM, US), Brazil (BL, BM, BS), Italy (IL, IM IS), Australia (AM), Spain (SM, SS), Germany (GS), Bulgaria (BuS). CS: Complementary sequence; N/A: Not analyzed. (DOCX 35Â kb)
Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation
Creators: name: Wu, Tingting
name: Cheng, Hu
name: Sima, Lijie
name: Wang, Zhongyuan
name: Ouyang, Weiwei
name: Wang, Jianta
name: Hou, Yunlei
name: Zhao, Dongsheng
name: Liao, Weike
name: Hu, Chujiao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with the inherent limitations of antibodies, driving them to pursue PD-L1 small molecule inhibitors. Virtual screening followed by experimental validation is a proven approach to discover active compounds. In this study, we employed multistage virtual screening methods to screen multiple compound databases to predict new PD-1/PD-L1 ligands. 35 compounds were proposed by combined analysis of fitness scores, interaction pattern and MM-GBSA binding affinities. Enzymatic assay confirmed that 10 out of 35 ligands were potential PD-L1 inhibitors, with inhibitory rate higher than 50% at the concentration of 30 µM. Among them, ZDS20 was identified as the most effective inhibitor with low micromolar activity (IC50 = 3.27 μM). Altogether, ZDS20 carrying novel scaffold was identified and could serve as a lead for the development of new classes of PD-L1 inhibitors.
Wagner on Welte: Tristan und Isolde around 1905
Creators: name: Bärtsch, Manuel
Publisher: name: transcript Verlag
Year: 2021

description: Dank Rollen-Aufnahmen aus dem Wagnerkreis – darunter mit Felix Mottl der Uraufführungsdirigent von Tristan – lässt sich zeigen, wie stark musikalische Zeitgestaltung und Dynamik verwendet wurden, um bei der Interpretation von Wagners Werken Form und Harmonik zu verdeutlichen.
ARPI e Linee di indirizzo dell'Università di Pisa sull'accesso aperto. Un lungo percorso appena iniziato
Creators: name: Benedetti, Gabriella
Publisher: name: Zenodo
Year: 2015
Subjects: subject: Social sciences
subject: FOS: Social sciences

description: Il percorso dell'Università di Pisa sul tema dell'Open Access. A oltre dieci anni dall'adesione alla Dichiarazione di Berlino: azioni, reazioni, percezioni. Cosa è cambiato e quali i possibili sviluppi?
Additional file 4: Table S4 of Identification of three new isolates of Tomato spotted wilt virus from different hosts in China: molecular diversity, phylogenetic and recombination analyses
Creators: name: Zhenjia Zhang
name: Deya Wang
name: Chengming Yu
name: Zenghui Wang
name: Jiahong Dong
name: Kerong Shi
name: Xuefeng Yuan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Summary of recombination events in different full-length TSWV L isolates using RDP4. NS: not significant. (DOCX 33Â kb)
Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy
Creators: name: Chen, Liuzeng
name: Wang, Ke
name: Liu, Xiaohan
name: Wang, Lifan
name: Zou, Hui
name: Hu, Shuying
name: Zhou, Lingling
name: Li, Rong
name: Cao, Shiying
name: Ruan, Banfeng
name: Cui, Quanren
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mental Health

description: Pterostilbene (PST) is a naturally derived stilbene compound in grapes, blueberries, and other fruits. It is also a natural dietary compound with a wide range of biological activities such as antioxidant, anti-inflammatory, antitumor, and so on. Structural modifications based on the chemical scaffold of the pterostilbene skeleton are of great importance for drug discovery. In this study, pterostilbene skeletons were used to design novel anti-inflammatory compounds with high activity and low toxicity. A total of 30 new were found and synthesised, and their anti-inflammatory activity and safety were screened. Among them, compound E2 was the most active (against NO: IC50 = 0.7 μM) than celecoxib. Further studies showed that compound E2 exerted anti-inflammatory activity by blocking LPS-induced NF-κB/MAPK signalling pathway activation. In vivo experiments revealed that compound E2 had a good alleviating effect on acute colitis in mice. In conclusion, compound E2 may be a promising anti-inflammatory lead compound.
Effects of Cooling on Ground Reaction Forces, Knee Kinematics, and Jump Height in Drop Jumps
Creators: name: Schmid, Stefan
name: Moffat, Marilyn
name: Gutierrez, Gregory M.
Year: 2013

description: This study investigated the effect of knee joint ice application on vertical ground reaction forces (VGRF), knee angle (KA), and jump height (JH) during a single-leg drop jump in 20 healthy participants randomly assigned to an experimental or control group. VGRF were measured using a force plate, KA was measured using an electrogoniometer, and JH was derived from VGRF. After the pretests, a crushed-ice bag was applied to the experimental group participants for 20 minutes, whereas the control group rested. All participants were retested immediately and again after 20 minutes of rest. Significant decreases in average braking phase VGRF (–0.18±0.14 body weight) and increases in contact time (51±39 ms) were found after icing. In addition, several nonsignificant trends toward force reduction were identified. These findings support the statement that when athletes return to competition after icing, an altered neuromuscular behavior might lead to potential re-injury situations.
Additional file 1: of Maternal risk factors and perinatal outcomes among pacific islander groups in Hawaii: a retrospective cohort study using statewide hospital data
Creators: name: Chang, Ann
name: Hurwitz, Eric
name: Miyamura, Jill
name: Bliss Kaneshiro
name: Tetine Sentell
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: Maternal outcomes. Diagnoses with respective ICD-9 codes. (DOCX 42 kb)
Musikalisches Körperwissen: Embodiment als Methode der (historischen) Interpretationsforschung.
Creators: name: Köpp, Kai
Year: 2016

description: Wir wurde die Musik der Romantik im 19. Jahrhundert aufgeführt? Schriftliche Instruktionen und historische Tondokumente geben Einblick in das musikalische Denken der Interpreten, zeigen ihre Haltung zur Tradition und widerspiegeln die geistigen Strömungen ihrer Zeit. Die Auswertung dieser einzigartigen Instruktionen am jeweiligen Instrument verlangt nach einer besonderen Methode: dem Embodiment, ein körperliches Nachvollziehen einer historischen Information. Anweisungen werden in Klang übersetzt, um Interpretations-Entscheidungen zu verstehen. Dieses Wissen befördert eine künstlerische und zugleich historisch informierte Interpretationspraxis romantischer Musikstücke.
JDL_2024_03
Creators: name: Frazer-McKee, Gabriel
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470499
subject: Linguistics not elsewhere classified
classificationCode: 470316
subject: Latin and classical Greek languages

description: Matériel en lien au processus d'évaluation du manuscrit JDL_2024_03, publié dans les Actes des Journées de Linguistique en 2024
Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors
Creators: name: Xu, Keren
name: Ying, Leyi
name: Ying, Titi
name: Wu, Qihao
name: Du, Lin
name: Yu, Yanlei
name: Ying, Youmin
name: Wei, Bin
name: Wang, Hong
name: Yang, Zhikun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: EcGUS has drawn considerable attention for its role as a target in alleviating serious GIAEs. In this study, a series of 72 (thio)urea derivatives were designed, synthesised, and biologically assayed. The bioassay results revealed that E-9 (IC50 = 2.68 μM) exhibited a promising inhibitory effect on EcGUS, surpassing EcGUS inhibitor D-saccharic acid-1,4-lactone (DSL, IC50 = 45.8 μM). Additionally, the inhibitory kinetic study indicated that E-9 (Ki = 1.64 μM) acted as an uncompetitive inhibitor against EcGUS. The structure-activity relationship revealed that introducing an electron-withdrawing group into the benzene ring at the para-position is beneficial for enhancing inhibitory activity against EcGUS. Furthermore, molecular docking analysis indicated that E-9 has a strong affinity to EcGUS by forming interactions with residues Asp 163, Tyr 472, and Glu 504. Overall, these results suggested that E-9 could be a potent EcGUS inhibitor, providing valuable insights and guidelines for the development of future inhibitors targeting EcGUS.
MOESM3 of N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models
Creators: name: Liljedahl, Leena
name: Pedersen, Maiken
name: Norlin, Jenny
name: McGuire, James
name: James, Peter
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 3. Additional file 3 includes panels A and B and shows proteins only identified in the STZ mouse model with significant protein abundances. Panel A shows graphs of selected proteins significance is calculated with two-tailed Student’s t test for equal variance, P
Publishing without perishing. Are there such things as "research products"?
Creators: name: Pievatolo, Maria Chiara
Publisher: name: Zenodo
Year: 2015
Subjects: subject: Political philosophy
subject: Platonic philosophy

description: At the end of Plato’s Phaedo, Socrates does not succeed in persuading Crito that the real Socrates is the Socrates who is now conversing and arranging the details of his argument, not the one whom he will soon see as a corpse. According to Ernst Cassirer, the philosopher is the one who knows how to die, by overcoming his individuality to participate in a universal conversation. Hence, while Crito’s Socrates has long become dust, Plato’s Socrates is still speaking to us: research is an unending process, not a competitive production of statical “research products”. If any research assessment is done à la Crito, by counting “products” and citations, academy may become so predatory and fraudulent that the difference between a respected scholar and an impostor faking his data would be just of degree, not of kind. And that the only viable route to open access, if any, would remain the grey road of administrative enforcement on scholars glad to be treated like zombies.
Additional file 6: of The impact of taphonomic data on phylogenetic resolution: Helenodora inopinata (Carboniferous, Mazon Creek LagerstĂ¤tte) and the onychophoran stem lineage
Creators: name: Murdock, Duncan
name: Gabbott, Sarah
name: Purnell, Mark
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Character coding. Character descriptions and character states from Yang et al. [4], for those characters modified in this analysis (TableÂ 1, Additional file 7), and/or those characters mapped as synapomophies (Additional file 5). (PDF 54 kb)
Additional file 2: Table S2. of Identification of three new isolates of Tomato spotted wilt virus from different hosts in China: molecular diversity, phylogenetic and recombination analyses
Creators: name: Zhenjia Zhang
name: Deya Wang
name: Chengming Yu
name: Zenghui Wang
name: Jiahong Dong
name: Kerong Shi
name: Xuefeng Yuan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Summary of recombination events in different full-length TSWV L isolates using RDP4. NS: not significant. (DOCX 24Â kb)
Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity
Creators: name: de Matos Czeczot, Alexia
name: Muniz, Mauro Neves
name: Perelló, Marcia Alberton
name: Silva, Éverton Edésio Dinis
name: Timmers, Luís Fernando Saraiva Macedo
name: Berger, Andresa
name: Gonzalez, Laura Calle
name: Gonçalves, Guilherme Arraché
name: Moura, Sidnei
name: Machado, Pablo
name: Bizarro, Cristiano Valim
name: Basso, Luiz Augusto
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The crystallographic structure of the FolB enzyme from Mycobacterium tuberculosis (MtFolB), complexed with its inhibitor 8-mercaptoguanine (8-MG), was elucidated at a resolution of 1.95 Å. A novel series of S8-functionalized 8-MG derivatives were synthesised and evaluated as in vitro inhibitors of dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of MtFolB. These compounds exhibited IC50 values in the submicromolar range. Evaluation of the activity for five compounds indicated their inhibition mode and inhibition constants. Molecular docking analyses were performed to determine the enzyme-inhibitor intermolecular interactions and ligand conformations upon complex formation. The inhibitory activities of all compounds against the M. tuberculosis H37Rv strain were evaluated. Compound 3e exhibited a minimum inhibitory concentration in the micromolar range. Finally, Compound 3e showed no apparent toxicity in both HepG2 and Vero cells. The findings presented herein will advance the quest for novel, specific inhibitors targeting MtFolB, an attractive molecular target for TB drug development.
Physiological and Perceptual Effects of Cooling Trousers: A Crossover Pilot Study
Creators: name: Wildmoser, Johanna
name: Clijsen, Ron
name: Hohenauer, Erich
Year: 2023

description: Introduction Cold-water immersion (CWI) is a commonly used recovery modality to positively affect subjective recovery parameters and reduce inflammatory reactions [1]. Because the use of CWI can be unpleasant and challenging, alternatives, such as cooling trousers by Icebein™, have been developed. Due to their novelty, there exists a lack of scientific research on the primary physiological and perceptual responses to these cooling trousers, which this pilot study seeks to examine. Methods Twelve healthy males (26±4.2 years old) volunteered to wear the Icebein™ cooling trousers for a duration of 20 min. with the water temperature set at 5ºC. Lower leg skin temperature (FLIR, A655, Kent, UK), skin perfusion of the m. quadriceps femoris vastus lateralis (moor VMS-LDF-1, Millwey, UK) and thermal perception (ISO 10551) were assessed at baseline, every 4 min. during the intervention (except skin temperature), and every 4 min. post-cooling up to 20 min. follow-up time.  Results Skin temperature significantly decreased from baseline to post-cooling (–12.4±5.63ºC, p<.001) and remained lower than baseline until the 20 min follow-up time (all: p<.001). Skin perfusion showed a significant decrease compared to baseline (p =0.038). Perfusion was decreased by 19.9±23.7% immediately post-cooling and by 22.1±26.4% at the end of the 20 min follow-up time. Wearing cooling trousers induced a significant perception of cold (p<.001) compared to baseline values. Discussion & conclusion The results show that the cooling trousers from Icebein™ elicit a significant skin-cooling reduction, decrease skin perfusion and induce a substantial perception of cold. These preliminary results demonstrate the physiological effects of this novel cooling strategy for potential performance recovery usage. Future studies should aim to directly compare the effects of cooling trousers and CWI with a larger sample size.
Additional file 1: of Metagenome-assembled genomes uncover a global brackish microbiome
Creators: name: Hugerth, Luisa
name: Larsson, John
name: Alneberg, Johannes
name: Lindh, Markus
name: Legrand, Catherine
name: Jarone Pinhassi
name: Andersson, Anders
Publisher: name: Figshare
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. The assembly and binning workflow. Figure S2. The correlation between various assembly parameter qualities and number of MAG generated. Figure S3. Heatmap of the similarity between each of the 83 MAGs generated. Figure S4. Phylum and class-level insets of the phylogeny of each MAG. Figure S5. NMDS of BACL based on their functional gene content. Figure S6. Heatmap of the abundance of glycoside hydrolases in each BACL. Figure S7. Heatmap of the abundance of transporters in each BACL. Figure S8. Core genome and pigment phylogeny of picocyanobacteria including BACL30. Figure S9. Pairwise scatterplots of various genomic features in MAGs and isolates. Figure S10. Line plots of physico-chemical parameters of the studied station throughout the year. Figure S11. Heatmap of the fragment recruitment by each BACL of various aquatic metagenomes from previous studies. Figure S12. Fragment recruitment dot plots for selected MAGs. Fig. S13 Principal coordinates analysis of functional gene content of various metagenomes showing salinity explains most of the variance. Table S1. ANOSIM results of clustering MAGs according to their coding potential. (PDF 6175 kb)
Hydrobaenus jacuticus Makarchenko et Makarchenko
Creators: name: Makarchenko, Eugenyi A.
name: Makarchenko, Marina A.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Hydrobaenus
Hydrobaenus jacuticus

description: Hydrobaenus jacuticus Makarchenko et Makarchenko
(Figs. 30–33)
Hydrobaenus jacuticus Makarchenko et Makarchenko, 2011: 392, Figs. 3–4.
Hydrobaenus kotsuki Makarchenko et Makarchenko, 2012: 121, Figs. 33 –47; syn. n.
Material. Far East of Russia. Sakha (Yakutia) Republic: 1 male, Neryungrinsky District, Gorbyllakh River, 1.VIII. 2010, leg. E. Makarchenko; 1 male, same data as previous except Chulman River, 2.VIII.2010, leg. T. Tiunova. Amurskyi Region: 1 male, extracted from mature pupa, 2 mature pupae, 1 pupa with larval skin, 4 larvae, Selemdzhinskyi District, Northern part of Zlatoustovsk Village, Kazachenskyi Stream (Zeya River basin), 25.VII.2008, leg. D. Kotsuk. Magadanskyi Region: 1 male, extracted from mature pupa, 2 mature pupa, 1 mature larva, Tenkinskyi District, environs of Sibit-Tyellakh Village, Olen’ Stream (Kolyma River basin), 24.VII.1977, leg. E. Makarchenko.
Remarks. This species was described by a single adult male from South Yakutia (Makarchenko & Makarchenko 2011). Later, from the Amur Region has been described a new species H. kotsuki Makarchenko et Makarchenko, 2012 by adult male, extracted from the mature pupae, as well as by pupa and larva. After comparing of this species with additional material from the Kolyma River basin, it became clear that the new species was described incorrectly and H. kotsuki should be synonymized with H. jacuticus. Below we present diagnosis of the male adult of this species by all materials from the Russian Far East.
Diagnosis. Adult male (n = 4). Total length 2.3–2.5 mm. Eyes with short dorsomedian prolongations, pubescent. Temporal setae including (from one side) 3–4 inner verticals, 1–2 outer verticals and 2–5 postorbitals. Clypeus with 4–6 setae. AR 0.93–1.22. Antepronotal lobes with 2–3 lateral setae. Acrostichals 5–6 (situated in middle of scutum), dorsocentrals 4–5, prealars 2–3. Scutellum with 6 setae. Wing length 1.7–1.8 mm. Costa extension 12 µm. Anal lobe well developed. Squama with 6–8 setae. LR1 0.64–0.72.
Hypopygium (Figs. 30–33). Tergite IX with 10–14 setae and nacked anal point, tapering to the top, 16–22 µm long. Transverse sternapodeme 80 µm long; oral projections roundish or roundish triangular. Dorsal part of inferior volsella with nacked and finger-shaped projection; ventral part roundish and covered by microtrichia and some setae. Gonostylus slightly curved, without crista dorsalis; megaseta 12 µm long. Virga consists of 2–4 black spines.
Distribution. Known from Amur and Kolyma River basins and south part of Sakha (Yakutia).
description: Published as part of Makarchenko, Eugenyi A. & Makarchenko, Marina A., 2014, On taxonomy of Hydrobaenus Fries, 1830 (Diptera: Chironomidae: Orthocladiinae) from the Russian Far East, with a key to species, pp. 429-438 in Zootaxa 3760 (3) on pages 436-437, DOI: 10.11646/zootaxa.3760.3.9, http://zenodo.org/record/231006
Additional file 1: of The impact of taphonomic data on phylogenetic resolution: Helenodora inopinata (Carboniferous, Mazon Creek Lagerstätte) and the onychophoran stem lineage
Creators: name: Murdock, Duncan
name: Gabbott, Sarah
name: Purnell, Mark
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Full resolution versions of images presented in Fig.  1a–d . RGB levels have been adjusted to better show the fossils, in some cases only in the region of the nodule that bears the fossil. For further details see caption at Fig. 1. (PDF 86713 kb)
Design and synthesis of triazolopyridine derivatives as potent JAK/HDAC dual inhibitors with broad-spectrum antiproliferative activity
Creators: name: Xu, Zhengshui
name: Ye, Changchun
name: Wang, Xingjie
name: Kong, Ranran
name: Chen, Zilu
name: Shi, Jing
name: Chen, Xin
name: Liu, Shiyuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer
Hematology

description: A series of triazolopyridine-based dual JAK/HDAC inhibitors were rationally designed and synthesised by merging different pharmacophores into one molecule. All triazolopyridine derivatives exhibited potent inhibitory activities against both targets and the best compound 4-(((5-(benzo[d][1, 3]dioxol-5-yl)-[1, 2, 4]triazolo[1, 5-a]pyridin-2-yl)amino)methyl)-N-hydroxybenzamide (19) was dug out. 19 was proved to be a pan-HDAC and JAK1/2 dual inhibitor and displayed high cytotoxicity against two cancer cell lines MDA-MB-231 and RPMI-8226 with IC50 values in submicromolar range. Docking simulation revealed that 19 fitted well into the active sites of HDAC and JAK proteins. Moreover, 19 exhibited better metabolic stability in vitro than SAHA. Our study demonstrated that compound 19 was a promising candidate for further preclinical studies.
article A-10-715-1.pdf
Creators: name: Fanisaberi, Amirmohsen
name: Torkashvand, Marzie
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 401609
subject: Polymers and plastics

description: Sound pollution, as of one of the main modern city irritations has become one of the paramount challenges of the current days. After COVID-19 outbreak many of the professional affairs concentrated at homes and residential areas. Many of the negotiations and conferences have been conducted at homes, where the noise level should be controlled. So, the proper addressing the problem, combining with the privilege of chemical composite synthesis is of great significance. In this paper a multilayer fire proof absorptive-insulator composite has been designed to control the acoustic parameters in residential areas. Apart from the desired acoustic parameters and inflammability, required in apartments, energy saving factors such as heat conductivity has also been optimized. The material has reached the absorption coefficient of 1, resulting in total sound absorption, and reasonable Sound Transmission Class (STC)
Shared Decision Making in the Psychiatric Inpatient Setting: An Ethnographic Study about Interprofessional Psychiatric Consultations
Creators: name: Gurtner, Caroline
name: Lohrmann, Christa
name: Schols, Jos M. G. A.
name: Hahn, Sabine
Publisher: name: MDPI
Year: 2022
Subjects: shared decision making
clinical practice
psychiatric inpatient setting
interprofessional psychiatric consultations
psychiatric disorder
mental illness
communication
patient involvement
patient-centered care
participant observation

description: Shared decision making is increasingly receiving attention in health care and might improve both the quality of care and patient outcomes. Nevertheless, due to its complexity, implementation of shared decision making in clinical practice seems challenging. This ethnographic study aimed to gain a better understanding of how psychiatric inpatients and the interprofessional care team interact during regular interprofessional psychiatric consultations. Data were collected through participant observation on two different psychiatric wards in a large psychiatric hospital in Switzerland. The observation focused on the contextual aspects of interprofessional patient consultations, the communication and interaction as well as the extent to which patients were involved in decision making. Participants included patients, psychiatrists, junior physicians, nurses, psychologists, social workers and therapists. We observed 71 interprofessional psychiatric consultations and they differed substantially in both wards in terms of context (place and form) and culture (way of interacting). On the contrary, results showed that the level of patient involvement in decision making was comparable and depended on individual factors, such as the health care professionals' communication style as well as the patients' personal initiative to be engaged. The main topics discussed with the patients related to pharmacotherapy and patient reported symptoms. Health care professionals in both wards used a rather unidirectional communication style. Therefore, in order to promote patient involvement in the psychiatric inpatient setting, rather than to focus on contextual factors, consultations should follow a specific agenda and promoting a bidirectional communication style for all parties involved is strongly recommended.
MOESM4 of Elaboration of bilateral symmetry across Knautia macedonica capitula related to changes in ventral petal expression of CYCLOIDEA-like genes
Creators: name: Berger, Brent
name: Thompson, Veronica
name: Aedric Lim
name: Ricigliano, Vincent
name: Dianella Howarth
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4. Primer sequences used for PCR and qPCR experiments. Product size obtained from Knautia macedonica is provided.
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase
Creators: name: Rojas-Prats, Elisa
name: Martinez-Gonzalez, Loreto
name: Gil, Carmen
name: Ramírez, David
name: Martinez, Ana
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Cell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for the treatment of oncological and neurodegenerative unmet diseases. All the known CDC7 inhibitors are ATP-competitives, lacking of selectivity enough for success in clinical trials. As allosteric sites are less conserved among kinase proteins, discovery of allosteric modulators of CDC7 is a great challenge and opportunity in this field. Using different computational approaches, we have here identified new druggable cavities on the human CDC7 structure and subsequently selective CDC7 inhibitors with allosteric modulation mainly targeting the pockets where the interaction between this kinase and its activator DBF4 takes place.