cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Raw Materials
title: Raw Materials
Creators: name: Chancerel, Pierre
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: Weltkrieg [1914-1918]
subject: o.P. Rohstoffwirtschaft
subject: Agrarprodukt
subject: Raw materials
subject: Farm produce
subject: o.P. World War, 1914-1918

description: Raw materials were vital during the First World War. Due to the armaments production, the belligerents’ needs increased significantly, while the available resources fell. Each country intended both to increase its resources and to use them more efficiently. This required broad state intervention that consisted in controlling the needs of domestic populations and administering the distribution of products. Raw materials were also at the core of the Allied cooperation to provide Europe and North America with all necessary supplies. This leads to the question of whether the war led to a change in the global trade of raw materials.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Sodium-cluster complexes : probability of formation, stability and mass spectra
Creators: name: Corbett, Jennifer Leontine
Publisher: name: University of British Columbia
Year: 2012

description: Accurate knowledge of aerosol size and composition is important for the understanding of their effects on both the atmosphere and the health of those who inhale them. Ultrafine aerosols (0.25 nm to 10 nm radius) and small clusters (2 molecules to 0.25 nm radius) can only be detected down to radii of a few nanometers and no chemical information is provided. A photoion spectrometer was previously built and is used to dope clusters and ultrafine aerosols with Na atoms. The subsequent Na-cluster complexes are then ionized by a UV laser. This technique is currently believed to be the softest ionization method available. Calculations were done to predict the efficiency of this system because a direct comparison with other systems cannot be made over the complete size range. These calculations include, the probability of a particle colliding with a Na atom in the oven, the average lifetime of Na-cluster complexes and their photoionization efficiency. Calculations in this thesis focus on the collision probability and include predictions as to the most efficient temperature of the Na oven for Na pick up. The temperature of the Na oven was also found to experimentally agree with the calculations, because the vapor pressure of Na plays a significant role in the collision probability. Characterization of the sodium doping technique was done through experiments comparing direct XUV ionization with UV ionization of small Na doped clusters. The fragmentation of acetic acid clusters was characterized for the monomer and oligomers up to the tetramer. It was found that up to two acetic acid molecules evaporated from the clusters. The Na doping technique also reveals a significant difference in the size distribution as seen by UV and XUV laser ionization for large dimethyl ether and acetic acid clusters, and a smaller yet visible difference for large water clusters. Different UV wavelengths were also investigated including wavelengths above and below the ionization energy of a lone Na atom. The Na doping technique was found to be a softer technique than direct ionization with XUV light, because no fragmentation of molecules occurred and evaporation was minimized.
Evolutionary branching in a stochastic population model with discrete mutational steps
Creators: name: Sagitov, S.
name: Mehlig, B.
name: Jagers, P.
name: Vatutin, V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Evolutionary branching is analysed in a stochastic, individual-based population model under mutation and selection. In such models, the common assumption is that individual reproduction and life career are characterised by values of a trait, and also by population sizes, and that mutations lead to small changes in trait value. Then, traditionally, the evolutionary dynamics is studied in the limit of vanishing mutational step sizes. In the present approach, small but non-negligible mutational steps are considered. By means of theoretical analysis in the limit of infinitely large populations, as well as computer simulations, we demonstrate how discrete mutational steps affect the patterns of evolutionary branching. We also argue that the average time to the first branching depends in a sensitive way on both mutational step size and population size.
description: 12 pages, 8 figures. Revised version
Anticipations, Recessions and Policy: An Intertemporal Disequilibrium Model
Creators: name: Blanchard, Olivier J.
name: Sachs, Jeffrey D.
Publisher: name: Columbia University
Year: 1982
Subjects: Managerial economics

description: This paper presents an intertemporal disequilibrium model with rational expectations, i.e. a model in which agents anticipate the future rationally, but in which prices and wages may not adjust fast enough to maintain continuous market clearing. Therefore, optimizing firms and households base their intertemporal plans on anticipations of both future quantity constraints and future prices. Such a model shows clearly that the effect of a policy depends not only on its current values but its anticipated path, After a presentation of the model and its basic dynamics, we therefore consider the effects of various paths of fiscal policy on the economy.
title: Recording the Experiences of War: Personal Accounts of World War I (USA)
title: Recording the Experiences of War: Personal Accounts of World War I (USA)
Creators: name: Lengel, Edward G.
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. USA
subject: Weltkrieg [1914-1918]
subject: Erlebnisbericht
subject: o.P. World War, 1914-1918--Personal narratives, American

description: The experiences of American soldiers, uniformed noncombatants, and civilians on the Western Front in the First World War never fully entered the popular American consciousness. The reasons for this are more complex than simply the relatively short duration of active American participation in the conflict. During and immediately after the war, American personal accounts mostly echoed official arguments that the United States had played a decisive military role on the Western Front. In the 1920s and 1930s a wave of more self-reflective accounts appeared, but a public preoccupied with the Great Depression largely ignored them. Finally, the 50th anniversary of the American entry into the war in 1967-1968 coincided with the powerful anti-war mood that Vietnam engendered.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Villes de la peur, Pratiques et discours sécuritaires au Brésil
Creators: name: Macadré, Alix
Publisher: name: Zenodo
Year: 2019
Subjects: brésil
violence
criminalité urbaine
peur
sécurité
racisme

description: Depuis la fin des années 70, le Brésil fait face à un inquiétante augmentation de la

criminalité urbaine. Parallèlement, la peur de la criminalité a progressivement pris une

importance significative dans la vie et le quotidien des individus et donne aujourd’hui lieu à

des pratiques et des discours sécuritaires qui tentent, matériellement et symboliquement, de

restaurer l’ordre dans un pays souvent jugé chaotique par ses propres citoyens. Perpétuant

des mécanismes hérités de la période esclavagiste, ces pratiques et discours sécuritaires

participent à la criminalisation d’une certaine frange de la population, actualisent les

différentes formes de ségrégations et, paradoxalement, entretiennent un cycle de la violence

plus qu’ils n’y mettent un terme.
Accurate Group Delay Measurement for Radial Velocity Instruments Using the Dispersed Fixed Delay Interferometer Method
Creators: name: Wang, Ji
name: Ge, Jian
name: Wan, Xiaoke
name: Lee, Brian
name: De Lee, Nathan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The dispersed fixed-delay Intereferometer (DFDI) method is attractive for its low cost, compact size, and multiobject capability in precision radial-velocity (RV) measurements. The phase shift of fringes of stellar absorption lines is measured and then converted to an RV shift via an important parameter, phase-to-velocity scale (PV scale), determined by the group delay (GD) of a fixed-delay interferometer. Two methods of GD measurement using a DFDI Doppler instrument are presented in this article: (1) GD measurement using white-light combs gen- erated by the fixed-delay interferometer and (2) GD calibration using an RV reference star. These two methods provide adequate precision of GD measurement and calibration, given the current RV precision achieved by a DFDI Doppler instrument. They can potentially be used to measure GD of an fixed-delay interferometer for submeter- precision Doppler measurement with a DFDI instrument. Advantages and limitations of each method are discussed in detail. The two methods can serve as standard procedures of PV-scale calibration for DFDI instruments and cross- checks for each other.
description: 19 pages, 7 figures, 3 tables, accepted by PASP
The Dollar and the Policy Mix: 1985
Creators: name: Sachs, Jeffrey D.
Publisher: name: Columbia University
Year: 1985
Subjects: Managerial economics
Finance
Economics

description: In 1971, Robert Mundell proposed a stunning solution to the three problems then affecting the U.S. economy: high inflation and unemployment, and a weak currency. Mundell suggested that the policy mix of fiscal expansion and monetary contraction could work to raise output, reduce inflation, and strengthen the currency at the same time. This policy mix has been pursued under the Reagan administration since 1981. The paper investigates the contributions of this policy mix to disinflation and output growth. It finds that the policy mix has contributed as much as three percentage points of the reduction in inflation during 1981-84, but that the gains against inflation due to the mix will likely be lost, or more than lost, in the future.
Resumen de resultados de la Encuesta a Creadores de Contenido Científico en Redes Sociales
Creators: name: GÁLVEZ-DE-LA-CUESTA, María-del-Carmen
name: ÁLVAREZ-GARCÍA, Sergio
name: GUTIÉRREZ-MANJÓN, Sergio
name: GERTRUDIS-CASADO, María-del-Carmen
Publisher: name: Zenodo
Year: 2023
Subjects: comunicación-científica
redes-sociales
divulgación-científica
creadores-de-contenido

description: Resumen de resultados de la Encuesta realizada a creadores y creadoras de contenido científico en redes sociales, en el marco de la investigación sobre estrategias en la creación de contenido científico en redes sociales
The Structure and Spectral Features of a Thin Disk and Evaporation-Fed Corona in High-Luminosity AGNs
Creators: name: Liu, J. Y.
name: Liu, B. F.
name: Qiao, E. L.
name: Mineshige, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We investigate the accretion process in high-luminosity AGNs (HLAGNs) in the scenario of the disk evaporation model. Based on this model, the thin disk can extend down to the innermost stable circular orbit (ISCO) at accretion rates higher than $0.02\dot{M}_{\rm Edd}$; while the corona is weak since part of the coronal gas is cooled by strong inverse Compton scattering of the disk photons. This implies that the corona cannot produce as strong X-ray radiation as observed in HLAGNs with large Eddington ratio. In addition to the viscous heating, other heating to the corona is necessary to interpret HLAGN. In this paper, we assume that a part of accretion energy released in the disk is transported into the corona, heating up the electrons and thereby radiated away. We for the first time, compute the corona structure with additional heating, taking fully into account the mass supply to the corona and find that the corona could indeed survive at higher accretion rates and its radiation power increases. The spectra composed of bremsstrahlung and Compton radiation are also calculated. Our calculations show that the Compton dominated spectrum becomes harder with the increase of energy fraction ($f$) liberating in the corona, and the photon index for hard X-ray($2-10 \rm keV$) is $2.2 < Γ< 2.7 $. We discuss possible heating mechanisms for the corona. Combining the energy fraction transported to the corona with the accretion rate by magnetic heating, we find that the hard X-ray spectrum becomes steeper at larger accretion rate and the bolometric correction factor ($L_{\rm bol}/L_{\rm 2-10keV}$) increases with increasing accretion rate for $f<8/35$, which is roughly consistent with the observational results.
description: 39 pages, 10 figures, 1 table, accepted for publication by ApJ
Synthesis of monolithic shape-stabilized phase
Creators: name: Marske, Felix
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: To reduce the primary energy demand for heating, thermal energy can be stored using shape-stabilized phase change materials (ss-PCMs). In this work, a Sol-Gel synthesis based on stabilized silica sol is developed for ss-PCMs with various melting points, high latent heat, and high compressive strength. The monolithic ss-PCMs have melting points around 20°C and PCM mass fractions up to 86 wt%. The compressive strength (~1.2 MPa at 10°C) and latent heat (~160 J/g) are high, allowing versatile applications of ss-PCMs in heaters, hot water storage tanks, and construction materials to enhance heat storage capacity or for passive cooling of photovoltaic and battery cells. The properties of ss-PCMs are improved by encapsulating smaller PCM droplets, which size can be adjusted during synthesis through the addition of polyvinyl alcohol and sodium lauryl sulfate.
description: Um den Primärenergiebedarf fürs Heizen zu senken, kann thermische Energie durch formstabilisierte Phasenwechselmaterialien (ss-PCMs) gespeichert werden. In dieser Arbeit wird eine Sol-Gel-Synthese ausgehend von stabilisiertem Silika-Sol für ss-PCMs mit verschiedenen Schmelzpunkten, hoher latenter Wärme und hoher Druckfestigkeit entwickelt. Die monolithischen ss-PCMs haben Schmelzpunkte um 20 °C und PCM-Massenanteile bis 86 wt%. Die Druckfestigkeit (~1,2 MPa bei 10 °C) und latente Wärme (~160 J/g) sind hoch und ermöglichen vielseitige Anwendungsfelder der ss-PCMs, z.B. in Gebäudeheizungen, Warmwasserspeichern und Baumaterialien zur Erhöhung der Wärmespeicherfähigkeit oder zur passiven Kühlung von Photovoltaik- und Batterie-Zellen. Hierbei verbessern sich die Eigenschaften der ss-PCMs durch Einkapselung kleinerer PCM-Tropfen, deren Größe über die Zusätze Polyvinylalkohol und Natriumlaurylsulfat während der Synthese einstellbar sind.
title: Post-war Societies (Africa)
title: Post-war Societies (Africa)
Creators: name: Nkwi, Walter Gam
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Afrika
subject: Gesellschaft
subject: Weltkrieg [1914-1918]
subject: Nachkriegszeit
subject: o.P. World War, 1914-1918
subject: Africa
subject: Social history--20th century

description: This article focuses on the Africans who fought in the First World War and the role they played in bringing about social transformation in postwar African societies. It sheds light on the ex-soldiers as entrepreneurs and missionaries. The essay concludes that the First World War soldiers were responsible both individually and collectively for the introduction of “modernity” and thus were “progressive” influences in their various societies. They were also responsible for disrupting certain socio-cultural traditions and thus introduced some elements of social instability in postwar Sub Saharan Africa.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
The State of Open Monographs Series
Creators: name: Science, Digital
name: Grimme, Sara
name: Holland, Cathy
name: Watkinson, Charles
name: Taylor, Mike
name: Kemp, Jennifer
Publisher: name: Digital Science
Year: 2020
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications
subject: 80799 Library and Information Studies not elsewhere classified
subject: 80706 Librarianship

description: Like many colleagues working in scholarly publishing we have seen rapid changes in the industry over the last few years.
Following a discussion on the future of the monograph at the 2018 ALPSP conference we collaborated with thought leaders from the book space to produce a report on The State of Open Monographs. This report was well received by the community, so as a follow up we wanted to continue to explore this specialized, but highly important, type of content with this blog series.

This blog series includes:

Introduction to The State of Open Monographs 2020
https://www.digital-science.com/blog/news/launching-our-blog-series-on-the-state-of-open-monographs-2020/
Opening Monographs in an Age of COVID-19
https://www.digital-science.com/blog/news/state-of-open-monographs-series-opening-monographs-in-an-age-of-covid-19/

Crossing the Rubicon – The Case for Making Chapters Visible
https://www.digital-science.com/blog/news/state-of-open-monographs-series-making-chapters-visible/
Numerical minimisation of Gutzwiller energy functionals
Creators: name: Bünemann, Jörg
name: Gebhard, Florian
name: Schickling, Tobias
name: Weber, Werner
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We give a comprehensive introduction into an efficient numerical scheme for the minimisation of Gutzwiller energy functionals in studies on multi-band Hubbard models. Our method covers all conceivable cases of Gutzwiller variational wave functions and has been used successfully in previous numerical studies.
description: 10 pages
Clinical and Mental Burden of Injuries Related to Vasovagal Syncope
Creators: name: Jorge, Juliana
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: Vasovagal syncope
subject: physical injury
subject: vasovagal syncope-related injuries
subject: quality of life
subject: Medicine and Surgery
subject: Mental Health

description: Background: Vasovagal syncope (VVS) is the most common form of syncope. Syncope might lead to injury, however, the risk, rate and mental impact of traumatic injuries due to VVS is not well established. A more thorough knowledge of the physical and mental repercussion syncope related injuries will help clinicians provide more effective and personalized care to their patients. Aims: We aimed to: (1) determine the proportion of patients injured due to VVS; (2) estimate frequency, severity, and predictors of injuries comparing VVS patients and cardiac syncope patients; (3) we examined whether sustaining an injury during syncope affects patient’s quality of life. Methods: Aim 1 involved a systematic review and meta-analysis including studies with data on the proportion of patients with injury due to VVS prior to study enrollment. In aim 2 we estimated the proportion of faints that are associated with injuries due to syncope during 1 year follow up, comparing VVS patients and cardiac syncope patients. Aim 3 consisted in quality of life evaluation through Health Related Quality of Life (HRQoL) questionnaires completed by VVS patients in 2 VVS randomized trials, comparing patients that fainted with and without injury. Results: In aim 1, more than 30% of patients have history of injury due to VVS, the likelihood of injury correlated with population age. We also observed an important risk of major injuries (13.9%). In aim 2, we detected that 14% of syncope spells in VVS patients resulted in injury, over 1 year, with severe injuries corresponding to only 4%. In aim 3, we identified that HRQoL was not cleared impacted in patients injured after a VVS recurrent episode compared to not injured. Conclusions: The results from this thesis concluded that injuries due to syncope are frequent, having occurred at least once in one-third of patients with VVS. And, although no significant changes in HRQoL attributable to syncope-related injuries were confirmed, future initiatives with a more comprehensive assessment of HRQoL might increase our ability to support VVS patients. VVS is not always a benign disease, multifaceted management approaches, including prevention of injuries and psychological wellbeing need to be emphasized.
Energy and Resource Allocation: A Dynamic Model of the "Dutch Disease"
Creators: name: Bruno, Michael
name: Sachs, Jeffrey D.
Publisher: name: Columbia University
Year: 1982
Subjects: Managerial economics
Finance

description: It is well known that a domestic resource discovery gives rise to wealth effects that cause a squeeze of the tradeable good sector of an open economy. The decline of the manufacturing sector following an energy discovery has been termed the "Dutch disease," and has been investigated in many recent studies. Our model extends the principally static analyses to date by allowing for: (1) short-run capital specificity and long-run capital mobility; (2) international capital flows; and (3) far-sighted intertemporal optimizing behavior by households and firms. The model is solved by numerical simulation.
Überlebensraten beim Prostatakarzinom in Abhängigkeit der Primärtherapie : eine registerbasierte Auswertung
Creators: name: Durka, Kilian Frederick
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: In dieser Arbeit wurde an einer registerbasierten Kohorte von 1913 Männern mit lokalem Prostatakarzinom das Gesamt- und krankheitsspezifische Überleben in Abhängigkeit der erfolgten Therapie mittels radikaler Prostatovesikulektomie (RPVE) oder Strahlentherapie (RT) untersucht. Die 5-Jahres-Gesamtüberlebensrate betrug für die RPVE 95,9% und bei der RT 90,8%. Die kumulative krankheitsspezifische 5-Jahres-Mortalitätsrate lag für die RPVE bei 2,1%, für die RT bei 5,6%. In der Cox-Regressionsanalyse lag für die RT das adjustierte Risiko zu versterben beim 1,9-fachen (95% KI 1,3 - 2,8) im Vergleich zur RPVE. Das adjustierte krankheitsspezifische Sterberisiko betrug für die RT das 1,9-fache (95% KI 0,8-4,8) gegenüber der RPVE. Zusammenfassend lässt sich eine Assoziation der RT mit einer höheren Gesamt- und krankheitsspezifischen Mortalität und damit ein Überlebensvorteil für die RPVE feststellen. Ein mutmaßliches Confouding infolge von Komorbiditäten konnte hierbei nicht berücksichtigt werden.
description: This work aimed to examine the overall and cancer specific survival using a clinical cancer registry-cohort of 1913 men with local prostate cancer after treatment with surgery (RPVE) or radiotherapy (RT). The 5-year overall survival rate was 95,9% for the RPVE and 90,8% for the RT. The cumulative cancer-specific mortality rate for RPVE was 2,1% and 5,6% for the RT. After cox regression analysis the adjusted hazard ratio for RT was 1,9 (95% CI 1,3-2,8) compared with RPVE. The cancer-specific hazard ratio for RT was 1,9 (95% CI 0,8-4,8) compared to RPVE. In conclusion we found an association for RT with higher overall and cancer-specific mortality compared with RPVE in men with local prostate cancer. However, we could not properly adjust for confounding effects of comorbidities.
High Unemployment in Europe: Diagnosis and Policy Implications
Creators: name: Sachs, Jeffrey D.
Publisher: name: Columbia University
Year: 1986
Subjects: Managerial economics
Economics

description: Econometric evidence suggests that the non-accelerating inflation rate of unemployment (the NAIRU) has risen sharply in Europe in the past fifteen years. In the first section of this paper, I review the recent proliferation of supply-side models that say interesting things about why the NAIRU has increased so substantially in Europe. In the second section of the paper, I employ a simple example to show how aggregate demand should optimally be managed in response to transitory and permanent supply shocks, especially those shocks that cause a persistent rise in the NAIRU. Also, I discuss some policy implications of the increasingly popular "hysteresis hypothesis," that the NAIRU itself is influenced by the time path of actual unemployment.
Bulk-edge correspondence for Chern topological phases: A viewpoint from a generalized index theorem
Creators: name: Fukui, T.
name: Shiozaki, K.
name: Fujiwara, T.
name: Fujimoto, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We explore the bulk-edge correspondence for topological insulators (superconductors) without time-reversal symmetry from the point of view of the index theorem for open spaces. We assume generic Hamiltonians not only with a linear dispersion but also with higher order derivatives arising from generic band structures. Using a generalized index theorem valid for such systems, we show the equivalence between the spectral flow of the edge states and the Chern numbers specifying the bulk systems.
description: 17 pages, final version
Incoherently pumped continuous wave optical parametric oscillator broadened by non-collinear phasematching
Creators: name: Storteboom, Jelle
name: Lee, Chris J.
name: Nieuwenhuis, Ab F.
name: Lindsay, Ian D.
name: Boller, Klaus-J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In this paper, we report on a singly resonant optical parametric oscillator (OPO) pumped by an amplified spontaneous emission (ASE) source. The pump focusing conditions allow non-collinear phasematching, which resulted in a 230 nm (190 cm$^{-1}$) spectral bandwidth. Calculations indicate that such phasematching schemes may be used to further broaden OPO spectral bandwidths.
description: 7 pages 4 figures
Design, synthesis and in vitro evaluation of novel inhibitors and degraders of Zn2+-dependent histone deacetylases
Creators: name: Darwish, Salma Abdelaziz Ahmed Hassan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Histon-Deacetylasen (HDACs) deacetylieren Histonen und Nicht-Histon-Proteinen. Die vorgestellte Arbeit zeigt die Entwicklung neuartiger Inhibitoren und Degrader von HDAC6 und HDAC8. Der Abbau dieser Enzyme ist ein aussichtsvoller Therapieansatz bei verschiedenen Krebsarten. Zwei der synthetisierten Degrader erzielten Abbau von HDAC8. Außerdem führte ein Degrader zu Abbau von HDAC6. Die Optimierung von zuvor beschriebenen Benzhydroxamaten führte zur Identifizierung neuartiger Inhibitoren für Schistosoma mansoni HDAC8 (smHDAC8). Der effektivste Hemmstoff zeigte eine dosisabhängige Abnahme der Lebensfähigkeit der Larven. Die synthetisierten Degradern und Inhibitoren zeigten keine oder schwache zytotoxischen Wirkungen gegen HEK293-Zellen. Basierend auf synthetisierten Benzhydroxamat smHDAC8 Inhibitoren wurde ein Modell der quantitativen Struktur-Aktivitäts-Beziehung erstellt, um mit einer hohen Verlässlichkeit die Aktivität zukünftiger Benzhydroxamate gegenüber smHDAC8 vorhersagen zu können.
description: Histone deacetylases (HDACs) deacetylate histones and non-histone proteins. The presented work shows the development of novel selective inhibitors and degraders to target HDAC6 and HDAC8. The degradation of these enzymes is a promising therapeutic approach in different cancers. Two of the synthesized degraders achieved HDAC8 degradation. Also, one degrader resulted in strong degradation of HDAC6. Through the optimization of previously reported benzhydroxamates, novel inhibitors for Schistosoma mansoni HDAC8 (smHDAC8) were identified. The most effective inhibitor showed pronounced dose-dependent decrease in the larvae viability. The synthesized degraders and inhibitors showed no or weak cytotoxic effects against HEK293 cells. Moreover, the binding modes and binding free energy of a pool of synthesized benzhydroxamate derivatives targeting smHDAC8 were studied to generate a QSAR model with a reliable predictive ability to predict the activity of future benzhydroxamates towards smHDAC8.
title: Afrikaner (Boer) Rebellion (Union of South Africa)
title: Afrikaner (Boer) Rebellion (Union of South Africa)
Creators: name: Wessels, André
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Südafrika
subject: Rebellion
subject: Weltkrieg [1914-1918]
subject: o.P. South Africa--History--Rebellion, 1914-1915

description: The South African government’s decision to actively support Britain in the war against Germany led to much dissatisfaction within the white Afrikaans-speaking community. By the second week of October 1914, open rebellion erupted in certain areas. 11,476 Afrikaners participated in an ill-conceived and misplaced revolt which government forces effectively supressed by the end of January 1915, but the political consequences would come back to haunt the government. This article examines the main causes of the rebellion and its aftermath.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Diagnosis of Supersymmetry Breaking Mediation Schemes by Mass Reconstruction at the LHC
Creators: name: Dutta, Bhaskar
name: Kamon, Teruki
name: Krislock, Abram
name: Sinha, Kuver
name: Wang, Kechen
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: If supersymmetry is discovered at the LHC, the next question will be the determination of the underlying model. While this may be challenging or even intractable, a more optimistic question is whether we can understand the main contours of any particular paradigm of the mediation of supersymmetry breaking. The determination of superpartner masses through endpoint measurements of kinematic observables arising from cascade decays is a powerful diagnostic tool. In particular, the determination of the gaugino sector has the potential to discriminate between certain mediation schemes (not all schemes, and not between different UV realizations of a given scheme). We reconstruct gaugino masses, choosing a model where anomaly contributions to supersymmetry breaking are important (KKLT compactification), and find the gaugino unification scale. Moreover, reconstruction of other superpartner masses allows us to solve for the parameters defining the UV model. The analysis is performed in the stop and stau coannihilation regions where the lightest neutralinos are mainly gauginos, to additionally satisfy dark matter constraints. We thus develop observables to determine stau and stop masses to verify that the coannihilation mechanism is indeed operational, and solve for the relic density.
description: 16 pages, 14 figures. Figure 7 updated to show top peak. Minor changes to other figures
Building blocks for data management in Geoscience Australia
Creators: name: Bastrakova, I.V.
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2012
Subjects: data standards
data management

description: Geoscience Australia (GA) is improving its stewardship and sharing of data and information products that are discoverable, freely accessible, interoperable, standardised, authoritative and able to be used by diverse stakeholders. The factors that impact on GA's ability to share its wealth of data and information assets are complex and interdependent but fall into three main areas of strategic focus; ICT, data custodianship and governance. GA has already begun to achieve some important building blocks towards data management including an Information Management Framework and the establishment of Architecture Committees and Scientific Communities of Practice to strengthen the governance of data and information. International, national and community standards are being applied by data custodians to facilitate discovery and access to our data, and to improve the interworkability of the content. New ICT tools and systems are being developed to provide internal and external users with a single entry point to discover, visualise and deliver GA data and products. The long term goal is to implement fully operational channels for the management, discovery and delivery of all GA data including 'BIG' data and 'the long tail of science'. This will entail a long term commitment to culture change, education and data management support.
An Overview of the Main Environmental Issues Affecting Kisumu and Lake Victoria's Winam Gulf
Creators: name: Gordon, Sharon
name: Walsh, Markus
name: Castro, Andrea
name: Maoulidi, Moumie
Publisher: name: Columbia University
Year: 2009
Subjects: subject: Managerial economics
subject: Africans
subject: Regional planning
subject: Ecology
subject: FOS: Biological sciences

description: This overview was produced in response to a request from the Mayor of Kisumu, who expressed the urgent need to deal with the deteriorating environment in and around the City and in the Winam Gulf of Lake Victoria. Researched and written by experts at the Earth Institute, the Millennium Cities Initiative (MCI) and the environmental team of the MDG Centre in Nairobi, it describes and analyses the current environmental condition in Kisumu and its surrounding catchment; discusses some of the factors contributing to the ongoing degradation, and proposes a set of recommendations for constructive action.
title: Science and Technology (Portugal)
title: Science and Technology (Portugal)
Creators: name: Assis, José Luís
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Portugal
subject: Weltkrieg [1914-1918]
subject: Technik
subject: o.P. World War, 1914-1918--Technology
subject: Portugal

description: This study focuses on the Portuguese war-related science and technology developments during the participation in the Great War by the Corpo Expedicionário Português (Portuguese Expeditionary Corps). It is rare to find writing on war-related science and technology topics and Portugal’s participation in the Great War. As an attempt to address this gap in the literature, this article will focus on the following topics: chemistry, weaponry, innovation, modernity and war technology.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
title: Züblin-Spiller, Else
title: Züblin-Spiller, Else
Creators: name: Joris, Elisabeth
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Züblin-Spiller, Else
subject: o.P. Spiller, Else (Züblin-Spiller, Else), 1881-1948

description: In the context of the Swiss organisation ''Schweizer Verband Soldatenwohl ''Else Spiller initiated facilities for soldiers providing alcohol-free catering (''Soldatenstuben'') and organized social support for families of needy soldiers (''Wehrmannsfürsorge''), a precursor of the federal law on income compensation for military service (''Lohn- und Verdienstsersatzordnung) ''founded during the Second World War. She is considered a pioneer of social work and staff canteens.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Atom-photon interactions in a system of coupled cavities
Creators: name: Amili, Abdelkrim El
name: Gleyzes, Sébastien
name: Westbrook, Christoph I
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optics (physics.optics)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We give a theoretical treatment of single atom detection in an compound, optical micro cavity. The cavity consists of a single mode semiconductor waveguide with a gap to allow atoms to interact with the optical field in the cavity. Optical losses, both in the semiconductor and induced by the gap are considered and we give an estimate of the cavity finesse. We also compute the cooperativity parameter and show how it depends on the gap width and cavity length. Maximization of the cooperativity does not always correspond to maximization of the coupling.
title: Wartime and Post-war Economies (Switzerland)
title: Wartime and Post-war Economies (Switzerland)
Creators: name: Straumann, Tobias
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: o.P. Schweiz
subject: Wirtschaft
subject: Weltkrieg [1914-1918]
subject: Nachkriegszeit
subject: o.P. Switzerland--Economic conditions--1918-1945
subject: World War, 1914-1918--Switzerland

description: Though Switzerland was not conquered, its economy was strongly affected by the First World War, negatively as well as positively. On the one hand, the import of foodstuff and raw materials deteriorated towards the end of the war and inflation reduced the purchasing power of a large part of the population. On the other hand, many exporting industrial firms enjoyed a strong demand for their products during the first half of the war, those selling strategic war material registered profits even until the end of the war. Overall, Switzerland’s economy fared better than the economies of the European belligerents.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
title: Martial Races, Theory of
title: Martial Races, Theory of
Creators: name: Liebau, Heike
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: Rassismus
subject: Militarismus
subject: o.P. Indien
subject: o.P. World War, 1914-1918--India
subject: Minorities

description: The notion of “martial races” was formally developed and codified in the wake of the Indian Uprising of 1857 and became an important basis for the recruitment policy of the Indian Army. Constantly manipulated and adapted to changing political and military requirements, and utilizing racial, social and religious criteria, the “martial races” theory was part of the reorganization strategy of the British Indian Army in the early years of the British Raj.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Einfluss der Proteinphosphatase 2Cβ auf die Funktion von Herzvorhöfen transgener Mäuse in vitro unter Hypoxie
Creators: name: Bruns, Tom Alfred
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Wir untersuchten die Wirkung einer erhöhten PP2C-Expression auf die Funktion isolierter Herzvorhöfe transgener Mäuse (TG) in vitro. Diese zeichneten sich durch eine kardiomyozytenspezifische Überexpression der PP2Cβ aus. Gemessen wurden Kontraktionskräfte und Frequenzen in vitro an elektrisch stimulierten linken und spontan schlagenden rechten Vorhofpräparaten. Unter Normoxie zeigten rechte Vorhofpräparate von TG höhere Frequenzen. Unter Hypoxie entwickelten die Präparate der Wildtyp-Geschwistertiere (WT) mehr Kraft als TG. TG verloren unter Hypoxie schneller ihre Kraft und regenerierten sie danach langsamer. Kontrakturen entwickelten sich in TG schneller als in WT, wurden jedoch auch schneller wieder abgebaut. Damit könnte PP2Cβ einen Einfluss auf die Herzfrequenz ausüben. Außerdem könnte PP2Cβ einen schnelleren Verlust der Kontraktilität und eine schlechtere Erholung bei Hypoxien mit erhöhtem Risiko für Kontrakturentwicklung bewirken.
description: We investigated the effect of an increased PP2C expression on the function of isolated atria of transgenic mice (TG) in vitro. These were characterized by cardiomyocyte-specific overexpression of PP2Cβ. Contraction forces and frequencies were measured in vitro in electrically stimulated left and spontaneously beating right atrial preparations. Under normoxia, right atrial preparations of TG showed higher frequencies. Under hypoxia, wild-type (WT) littermate preparations developed more force than TG. TG lost force more rapidly under hypoxia and regenerated it more slowly thereafter. Contractures developed more rapidly in TG than in WT, but were also recovered more rapidly. Thus, PP2Cβ could exert an influence on heart rate. In addition, PP2Cβ could cause a more rapid loss of contractility and poorer recovery when facing myocardial hypoxia with increased risk for contracture development.
ОБЗОР ФАРМАКОЛОГИЧЕСКОЙ АКТИВНОСТИ СБОРА "ДИУРЕН"
Creators: name: Маккамов, Х.К.
name: Султанова, Р.Х.
Publisher: name: Zenodo
Year: 2025

description: В статье представлен обзор фармакологических свойств растительного мочегонного сбора "Диурен", разработанного на основе локальных растений Республики Узбекистан. Рассматриваются современные исследования, посвященные его токсикологической безопасности, диуретическому действию, влиянию на натрий-калиевый обмен и противовоспалительный потенциал. Проведен анализ научных данных, подтверждающих эффективность и безопасность "Диурена" как перспективного фитопрепарата.
title: Charles I, Emperor of Austria
title: Charles I, Emperor of Austria
Creators: name: Rill, Robert
Publisher: name: BSB - Bavarian State Library
Year: 2015
Subjects: subject: Karl [I., Österreich, Kaiser]
subject: Charles I, Emperor of Austria, 1887-1922

description: In his youth, the archduke was introduced to the idea of federalism by Archduke Franz Ferdinand. During the first part of World War I, he became a skillful military leader without any political influence. The young emperor’s two main aims, the reform of the Austrian Constitution and an acceptable peace, proved to be out of reach. Nevertheless, he consistently refused to resign and died in exile.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Molecular and physiological responses to elevated temperatures in Arabidopsis thaliana and barley
Creators: name: Bellstädt, Julia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 570

description: Zu thermomorphogenen Reaktionen von Arabidopsis thaliana Keimlingen zählen die temperatur-induzierte Verlängerung von Wurzel, Hypokotyl und Petiolen. Die Aufdeckung der molekularen Signalkomponenten, die diese Wachstumsreaktionen regulieren, hat in den letzten zehn Jahren erhebliche Fortschritte gemacht. Es ist jedoch immer noch nicht bekannt, ob es sich bei der Temperaturwahrnehmung und -reaktion um universelle Prozesse handelt, die in allen Pflanzenorganen gleichmäßig ablaufen. In meiner Arbeit konnte ich zeigen, dass die Thermomorphogenese in A. thaliana sowohl auf autonome, als auch intraorgan-spezifische Temperaturwahrnehmungs- und Temperatursignaling-Mechanismen beruht. Die Temperaturreaktionen des Sprosses erfordern sowohl lokale als auch systemische Prozesse, während Wurzeln Temperaturen unabhängig vom Spross wahrnehmen und darauf reagieren können. Neben der Untersuchung von Temperaturreaktionen in A. thaliana habe ich ähnliche Reaktionen in Hordeum vulgare untersucht.
description: Increased elongation of roots, hypocotyls and petioles in warm temperatures are hallmarks of seedling thermomorphogenesis. The identification of molecular signaling components regulating these growth responses has made significant progress over the past decade. However, it is still unknown, whether temperature sensing and responses are universal processes that occur uniformly in all plant organs. Here, I could show that seedling thermomorphogenesis in Arabidopsis thaliana involves autonomous as well as organ-interdependent temperature sensing and signaling. Shoot temperature responses require local as well as systemic processes, whereas seedling roots can sense and respond to temperature independently of shoot-generated systemic signals. While focusing on A. thaliana, I studied similar responses in the Hordeum vulgare. By assessing warmth-induced growth in barley, I analyzed whether the responses identified in A. thaliana can be transferred to distantly related crops.
Capillary electrophoresis-mass spectrometry separation of isomeric biological compounds
Creators: name: Soliman, Laiel
Publisher: name: University of British Columbia
Year: 2012

description: Current prostate cancer (PCa) diagnosis based on prostate-specific antigen (PSA) has been gradually losing its credibility over the last decade due to contradictory results in published literature and clinical practice. Recently, a group of potential PCa biomarkers in urine, particularly sarcosine, was found to increase significantly as the cancer progressed to metastasis. In Chapter 2, we report a simple, robust, and reproducible capillary electrophoresis–electrospray ionization–tandem mass spectrometry (CE–ESI-MS/MS) method for the determination of sarcosine and other representative potential biomarkers in pooled urine. A solid phase extraction (SPE) technique was optimized for maximum recovery of sarcosine. With no derivatization step, excellent resolution between sarcosine and its isomers (α-alanine and β-alanine) was achieved. A separate non-SPE method was also developed for quantitative determination of highly concentrated urinary metabolites. Precision for intra- and inter-day standard addition calibration of sarcosine were found to be within 15%, whereas intra-day precisions for the rest of the metabolites varied from 0.03 to 13.4%. Acceptable intra-day and inter-day accuracies, ranging from 80 to 124%, were obtained for sarcosine and the other metabolites. The second part of the thesis takes on a more challenging task. The importance of chiral separation in pharmaceutical, agriculture, and food industries has driven separation scientists to develop more powerful methodologies in conjunction with the structural capabilities of mass spectrometry. In Chapter 3, chiral separation of D- and L-tryptophan was compared on a bare-fused silica capillary and a PEI-coated capillary. Although a higher resolution was observed for uncoated capillaries, analytes were found to migrate slower resulting to longer analysis times (tm > 20 min). With shorter migration times (tm < 10 min) and acceptable resolution, further investigations on different factors that could affect enantioseparation were conducted on a coated capillary. Highly-sulfated cyclodextrins (HS-CDs), a group of charged CD derivatives, were also utilized for the separation of several racemic amino acids. Resolution with HS-CDs was found to be superior to using native CDs. Unfortunately, due to time constraint, no MS work was presented as the chiral CE/MS work is still currently in progress.