cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: ÐÐ´Ð½Ð¾ÑÐ¿Ð¸Ð½Ð¾Ð²ÑÐµ Ð°ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸Ð¸ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐ°Ñ ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð¿ÑÐ¾ÑÐ¾Ð½Ð¾Ð² Ñ Ð¿ÑÐ¾ÑÐ¾Ð½Ð°Ð¼Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Single-Spin Asymmetries in collisions of polarized protons with protons
Creators: name: ÐÐ¶Ð¾Ð², ÐÐ¼Ð¸ÑÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¾Ð´Ð½Ð¾ÑÐ¿Ð¸Ð½Ð¾Ð²ÑÐµ Ð°ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸Ð¸
ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ
Ð½ÐµÐ¿ÐµÑÑÑÑÐ±Ð°ÑÐ¸Ð²Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ
single-spin asymmetries
numerical methods
nonperturbative methods

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸ÑÑÐ»ÐµÐ´ÑÐ¾Ð²Ð°Ð»Ð¸ÑÑ Ð¾Ð´Ð½Ð¾ÑÐ¿Ð¸Ð½Ð¾Ð²ÑÐµ Ð°ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸Ð¸ (SSA), Ð²Ð¾Ð·Ð½Ð¸ÐºÐ°ÑÑÐ¸Ðµ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐ°Ñ ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð¿ÑÐ¾ÑÐ¾Ð½Ð¾Ð² Ñ Ð½ÐµÐ¿Ð¾Ð»ÑÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÐ¼Ð¸ Ð¿ÑÐ¾ÑÐ¾Ð½Ð°Ð¼Ð¸. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¾ÑÑÐµÐ´Ð¾ÑÐ¾ÑÐµÐ½Ð¾ Ð½Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ðµ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹, Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÑÑÐ¸Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ñ ÑÐ°ÑÑÐµÑÐ° Ð´Ð°Ð½Ð½ÑÑ Ð°ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸Ð¹. ÐÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÐ¼ ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ Ð´Ð»Ñ ÑÐ°ÑÑÐµÑÐ° SSA. ÐÑÐ½Ð¾Ð²Ð½Ð¾Ð¹ ÑÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼ÐµÑÐ¾Ð´Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÑÐ°ÑÑÐµÑÐ° Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¾Ð´Ð½Ð¾ÑÐ¿Ð¸Ð½Ð¾Ð²ÑÑ Ð°ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸Ð¹, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ðµ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° Ð´Ð»Ñ ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð²ÑÑÐ¸ÑÐ»ÐµÐ½Ð¸Ñ SSA Ñ ÑÑÐµÑÐ¾Ð¼ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐµÐ½Ð¾Ð¼ÐµÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð² Ð¸ Ð½Ð°Ð±Ð¾ÑÐ¾Ð² Ð¿Ð°ÑÑÐ¾Ð½Ð½ÑÑ ÑÑÐ½ÐºÑÐ¸Ð¹ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¸ ÑÑÐ½ÐºÑÐ¸Ð¹ ÑÑÐ°Ð³Ð¼ÐµÐ½ÑÐ°ÑÐ¸Ð¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÑ Ð¿ÑÐ¾ÑÐ¾Ð½Ð¾Ð² Ð¸ Ð¿ÑÐ¾Ð²ÐµÑÐºÐ¸ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð½ÐµÐ¿ÐµÑÑÑÑÐ±Ð°ÑÐ¸Ð²Ð½Ð¾Ð¹ QCD.
description: This work investigates single-spin asymmetries (SSA) that arise in collisions of polarized protons with unpolarized protons. The research focuses on analyzing theoretical models that describe the methods for calculating these asymmetries. We employ numerical methods to calculate SSA. The primary objective of this work is to develop a methodology for calculating and analyzing single-spin asymmetries, as well as to create an algorithm for numerical computation of SSA, taking into account various phenomenological approaches and sets of parton distribution functions and fragmentation functions. The obtained results can be used for further research into the spin structure of protons and for testing theoretical models of non-perturbative QCD.
Analysis of thermodynamic behaviour of valuable elements and slag structure during e-waste processing through copper smelting
Creators: name: Shuva, Mohahmad
Publisher: name: Swinburne
Year: 2024

description: Waste of electronics and electrical equipment and other end-of-life high technology products can be viewed as resources for metals, as they do not only contain the common metals but also trace valuable and rare elements. Every elements have different thermodynamic properties that govern the partitioning behaviour during the process. The present study investigated the thermodynamic behaviour of germanium, palladium and tantalum metals and determine their distribution-ratio in slag-metal equilibrium reaction during black copper processing. Moreover, it also examined the ferrous-calcium-silicate slag structure using vibrational spectroscopy and correlation between the degree of polymerization and distribution-ratio was developed using multiple regression analysis.
title: Ð Ð¾Ð¶Ð´ÐµÐ½Ð¸Ðµ K*(892) Ð¼ÐµÐ·Ð¾Ð½Ð° Ð² ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸ÑÑ Au+Au Ð¿ÑÐ¸ ÑÐ½ÐµÑÐ³Ð¸Ð¸ 200 ÐÑÐ Ð½Ð° Ð½ÑÐºÐ»Ð¾Ð½
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Production of K*(892) meson in Au+Au collision system at 200 GeV per nucleon
Creators: name: ÐÐ½ÑÑÐ¿Ð¾Ð², Ð¡ÐµÑÐ³ÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐºÐ²Ð°ÑÐº-Ð³Ð»ÑÐ¾Ð½Ð½Ð°Ñ Ð¿Ð»Ð°Ð·Ð¼Ð°
ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ ÑÑÐ¶ÐµÐ»ÑÑ ÑÐµÐ»ÑÑÐ¸Ð²Ð¸ÑÑÑÐºÐ¸Ñ ÑÐ´ÐµÑ
ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð½ÑÐ¹ Ð²ÑÑ Ð¾Ð´ ÑÑÑÐ°Ð½Ð½Ð¾ÑÑÐ¸
Ð¼ÐµÐ·Ð¾Ð½
Ð¸Ð½Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ½ÑÐ¹ ÑÐ¿ÐµÐºÑÑ
ÑÐ°ÐºÑÐ¾ÑÑ ÑÐ´ÐµÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸
quark-gluon plasma
relativistic heavy ion collisions
meson
strange enhancement
invariant spectra
nuclear modification factors

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¸ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐµ PHENIX, ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð¼ Ð² RHIC, Ð² Au+Au ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸ÑÑ Ð¿ÑÐ¸ ÑÐ½ÐµÑÐ³Ð¸Ð¸ \sqrt(s_NN) = 200 ÐÑÐ Ð´Ð»Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸Ð½Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ½ÑÑ p_T ÑÐ¿ÐµÐºÑÑÐ¾Ð² Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² ÑÐ´ÐµÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ K*(892) Ð¼ÐµÐ·Ð¾Ð½Ð°. ÐÑÐ½Ð¾Ð²Ð½ÑÐ¼ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð°, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑÐµÐ³Ð¾ Ð²ÑÐ´ÐµÐ»Ð¸ÑÑ Ð·Ð½Ð°ÑÐ¸Ð¼ÑÐ¹ ÑÐ¸Ð³Ð½Ð°Ð» K*(892). ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½ÑÐ¹ Ð¾Ð±Ð·Ð¾Ñ Ð¿Ð¾ ÑÐµÐ¼Ð°Ð¼: ÐºÐ²Ð°ÑÐº-Ð³Ð»ÑÐ¾Ð½Ð½Ð°Ñ Ð¿Ð»Ð°Ð·Ð¼Ð°, ÑÐµÐ»ÑÑÐ¸Ð²Ð¸ÑÑÑÐºÐ¸Ðµ ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ ÑÑÐ¶ÐµÐ»ÑÑ ÑÐ´ÐµÑ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð¾Ð±Ð·Ð¾Ñ Ð¸ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ Ð´ÐµÑÐµÐºÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ PHENIX. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ Ð´Ð»Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ ÑÐ¸Ð³Ð½Ð°Ð»Ð° K*(892). ÐÑÐ»Ð° ÑÐ°ÑÑÑÐ¸ÑÐ°Ð½Ð° Ð¿Ð¾Ð¿ÑÐ°Ð²ÐºÐ° Ð½Ð° ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐµÐ³Ð¸ÑÑÑÐ°ÑÐ¸Ð¸ ÑÐ¸Ð³Ð½Ð°Ð»Ð¾Ð² K*(892) Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ ÐµÐµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ðº ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐ¼ Ð´Ð°Ð½Ð½ÑÐ¼ Ð´Ð»Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸Ð½Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ½ÑÑ p_T ÑÐ¿ÐµÐºÑÑÐ¾Ð² Ð¸ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² ÑÐ´ÐµÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ K*(892) Ð¼ÐµÐ·Ð¾Ð½Ð°.
description: This work is dedicated to processing and studying experimental data acquired by PHENIX experiment located at RHIC in Au+Au collisions at sqrt(s_NN) = 200 GeV for calculation of invariant p_T spectra and nuclear modification factors of K*(892) meson. The main purpose of this work is development of an algorithm that allows to extract a signal of K*(892). Literature topics that were reviewed: quark-gluon plasma, relativistic heavy ion collision. PHENIX detector system was reviewed and described. Different methods for extracting signals of K*(892) were developed. Efficiency reconstruction correction was calculated and applied for experimental data for obtaining invariant p_T spectra and nuclear modification factors.
Death of a Child to Tay-Sachs and other progressive neurological disorders: Long-term impact on parents’ emotional and personal lives
Creators: name: Williams, Elizabeth
Publisher: name: Brandeis University
Year: 2014
Subjects: parental bereavement
posttraumatic growth
grief
life-limiting illness
Tay-Sachs Disease
meaning-making

description: Caring for and surviving the death of a child with a life-limiting illness has a profound and\r lasting effect on parents’ lives. Many studies have explored the emotional changes parents may experience shortly after their loss, but few have examined the long-term effects. It is important for genetic counselors that may work with these families to understand the range of experiences that can come with time. To explore the long-term experience, we designed an online anonymous survey that included questions about the deceased child’s illness and death, validated assessments of prolonged grief and posttraumatic growth, as well as questions about relationships with family, friends, work, and faith. We requested the participation of parents whose children died two or more years ago to a life-limiting, progressive, neurological condition through the National Tay-Sachs & Allied Diseases Association (NTSAD) and the National Mucopolysaccharidoses Society (MPS Society). Our study population, on average, experienced a moderate amount of posttraumatic growth, with a mean score of 27.62 on a 0-50 scale with highest scores in the subfactors of “appreciation of life” and “personal strength”. Some parents in our study reported difficulty motivating themselves for certain activities and trouble connecting with people who had not experienced a similar loss, but only a small minority of the study population met criteria for prolonged grief disorder (PGD). Since the death of their affected child, parents widely reported improvement in their relationships with their other children but little change in their relationships with parents, siblings, friends, colleagues and their work. Relationships with their partner or child’s other parent, as well as their personal faith and faith community experienced larger proportions of change, resulting in an almost even split between better, worse, and neither. Almost all of our 62 participants reflected on the care of their affected child without regret. The results of this study highlight the coexistence of difficulty and positive change in bereaved parents as well as the importance of support both during and after their child’s illness and death.
Designing an Accessible Form for Pre-Session Education of Cancer Genetic Counseling Patients
Creators: name: Parece, Lucian Bailey
Publisher: name: Brandeis University
Year: 2023
Subjects: cancer genetic counseling
educational tool
patient perspectives
pre-session education

description: Cancer genetic counselors are uniquely trained to help patients navigate through complex information and decision making regarding hereditary cancer testing, all while providing emotional support. Effective genetic counseling in the cancer setting is vital given that information from this testing can allow patients to be proactive with their medical care. This study aimed to determine the utility of a pre-session educational form in preparing patients for what to expect from cancer genetic counseling and in increasing perceived benefits and patient satisfaction with their session. Patients referred to UMass Memorial Health for cancer genetic counseling received a recruitment notice and consent information to participate in this study via MyChart prior to their counseling session. A subset of those who enrolled were sent the pre-session educational form to review prior to seeing a genetic counselor; the remainder of those enrolled were not sent the form in order to develop a control group. Following their sessions, patients filled out an anonymous online survey to assess both their perceptions of, and satisfaction with, genetic counseling, as well as the utility of receiving the pre-session educational form. The majority of participants who read the form strongly or somewhat agreed (64.7%, n=11) that they gathered family history for their visit because they read the form, and slightly more than half strongly or somewhat agreed (52.9%, n=9) that the form gave them new information regarding their session that they would not have known otherwise. Participants who did not read the form felt that receiving instructions on gathering family history, as well as information on what a genetic test could tell a person, before a session, would have been most useful. The majority of all participants, regardless of whether or not they read the form, were extremely satisfied (93.1%, n=27) with their overall genetic counseling experience. Most participants, whether they read the form or not, were extremely or somewhat satisfied (96.6%, n=28) with the quality of information they received during their session, and nearly all strongly agreed (93.1% n=27) that information in their session was presented in a way that they could understand.
Science Communication in Anthropology (ANTH 499.02) Flyer
Creators: name: TUSHINGHAM, SHANNON
name: Lipe, William D.
Publisher: name: Washington State University
Year: 2021
Subjects: subject: American History
subject: Anthropology
subject: FOS: Sociology
subject: Archaeology

description: This flyer advertises the course ANTH 499.02: Science Communication in Anthropology, Public Engagement and the Pioneers in Americanist Archaeology Project. This project project involved research on individuals who have made substantial leadership contributions to archaeology and cultural resource management. The project was spearheaded by WSU faculty Shannon Tushingham and William Lipe, and included research and undergraduate and graduate student class projects. As a public archaeology and science communication project, students were directed to research, write, and publish a Wikipedia biography about one of the “Pioneers”. Many of these individuals remain unknown and their contributions underappreciated, largely because much research has not been compiled or communicated in an engaging way. This is an ongoing pedagogical experiment in engaged research methods that focuses on scientific dissemination in Wikipedia, which, love it or hate it, it is one of the most heavily used sources of information on the internet.
Measuring the progress and outcome of forensic mental health patients
Creators: name: Shinkfield, Gregg
Publisher: name: Swinburne
Year: 2024

description: Implementation of Routine Outcome Measures to assess clinical and mental health functioning has become common practice since the early 1990’s. However, concern has been expressed about the use of these tools with forensic mental health populations. Over a series of four studies, this thesis examined the outcome measures that are currently mandated for use within forensic mental health settings in Victoria, Australia. These tools were compared with a series of forensic-specific tools to identify which were most useful for this task. The findings of this thesis have significant implications for forensic mental health services internationally.
A Search for Long-Lived Heavy Neutral Leptons in Events with Displaced Vertices Using the ATLAS Experiment
Creators: name: Addepalli, Sagar Vidya
Publisher: name: Brandeis University
Year: 2024
Subjects: ATLAS Experiment
CERN
Displaced Vertex
Heavy Neutrinos
Large Hadron Collider
Long-Lived Particles

description: The existence of right-handed neutrinos with Majorana masses below the electroweak scale could give rise to the smallness of neutrino masses and matter-antimatter asymmetry in the universe. This analysis searches for long-lived right-handed neutrinos, called heavy neutral leptons (HNLs), produced through a W boson decaying into a muon (electron) and a muon (electron) (anti-)neutrino that will mix with an HNL. The ATLAS reconstruction chain went through significant improvements in preparation for data taking in 2022. The improved techniques for reconstructing the displaced signature of the long-lived HNL are applied to 140.1 fb-1 of data used in this analysis collected at √s = 13 TeV in 2015–2018. The search results are interpreted in scenarios where the HNL mixes with one more Standard Model neutrino.
The integration of statistical and automatic process control in the continuous processing industries.
Creators: name: Slocomb, Richard A. W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Engineering, Chemical.

description: A unique problem in the continuous processing industries (CPI), arising from integration of statistical process control (SPC) with automatic process control (APC), is choosing the correct variable(s) for process monitoring. It was shown that the manipulated variable displayed superior process monitoring potential for first-order processes with moderate amounts of inertia, subject to an ARMA(1,1) disturbance when the autoregressive parameter, $\phi$, is larger than the moving average parameter, $\theta$. It was also shown for large amounts of process inertia that the reconstructed output (disturbance) was the most effective charting variable ($\phi > \theta$). However, when $\theta$ exceeds $\phi$ the residual chart performed the best. In some very severe cases, process observations are so highly correlated that they display a wandering mean. Such nonstationary disturbances are extremely problematic in the CPI. The n$\sp{\rm th}$-difference chart developed in this work, proved to be efficient at identifying the presence of assignable cause in first-order processes under Minimum Variance feedback control when subjected to IMA(1,1) disturbances displaying moderate degrees of nonstationarity ($\theta >$ 0.7). Furthermore, it was shown that the performance of these charts is significantly affected by the presence of the autoregressive parameter (ie., when $\phi >$ 0.2). A case study involving a C$\sb3$ splitter provided the basis for development of a six-step procedure for the integration of SPC with APC. While carrying out integration on the C$\sb3$ splitter it was determined that the cause of disturbance nonstationarity must be sought out and removed if successful integration is to be achieved. For most nonstationary disturbances the amount of natural drift is often greater than or equal to the size of the step shifts that one is trying to detect. Thus, one is not able to differentiate between the common cause and assignable cause disturbances. (Abstract shortened by UMI.)
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Creators: name: Robinson, Peter N. [U.V.M.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Protein function prediction
subject: Disease gene prioritization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction. However, assessing methods for protein function prediction and tracking progress in the field remain challenging. Results We conducted the second critical assessment of functional annotation (CAFA), a timed challenge to assess computational methods that automatically assign protein function. We evaluated 126 methods from 56 research groups for their ability to predict biological functions using Gene Ontology and gene-disease associations using Human Phenotype Ontology on a set of 3681 proteins from 18 species. CAFA2 featured expanded analysis compared with CAFA1, with regards to data set size, variety, and assessment metrics. To review progress in the field, the analysis compared the best methods from CAFA1 to those of CAFA2. Conclusions The top-performing methods in CAFA2 outperformed those from CAFA1. This increased accuracy can be attributed to a combination of the growing number of experimental annotations and improved methods for function prediction. The assessment also revealed that the definition of top-performing algorithms is ontology specific, that different performance metrics can be used to probe the nature of accurate predictions, and the relative diversity of predictions in the biological process and human phenotype ontologies. While there was methodological improvement between CAFA1 and CAFA2, the interpretation of results and usefulness of individual methods remain context-dependent.
title: Ð Ð°ÑÑÑÑÐ½Ð¾-ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ðº ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐµ Ð½ÑÐ»ÐµÐ²Ð¾Ð¹ Ð¿Ð»Ð°ÑÑÐ¸ÑÐ½Ð¾ÑÑÐ¸ Ñ Ð»Ð°Ð´Ð¾ÑÑÐ¾Ð¹ÐºÐ¸Ñ ÑÑÐ´Ð¾ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÑÐ°Ð»ÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Ð¡omputational and experimental substantiation of requirements for nil-ductility temperature of cold-resistant shipbuilding steels
Creators: name: ÐÐ°ÑÐ°ÐºÐ¾Ð², ÐÐ°Ð½Ð¸Ð»Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐ° Ð½ÑÐ»ÐµÐ²Ð¾Ð¹ Ð¿Ð»Ð°ÑÑÐ¸ÑÐ½Ð¾ÑÑÐ¸
Ñ Ð»Ð°Ð´Ð¾ÑÑÐ¾Ð¹ÐºÐ¸Ðµ ÑÑÐ´Ð¾ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÐµ ÑÑÐ°Ð»Ð¸
zero ductility temperature
cold-resistant shipbuilding steels

description: Ð Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÐ°ÑÑÐµÑÐ¾Ð² ÐÐÐ­ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð° Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ñ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÑ Ð½ÑÐ»ÐµÐ²Ð¾Ð¹ Ð¿Ð»Ð°ÑÑÐ¸ÑÐ½Ð¾ÑÑÐ¸ (NDT) Ñ ÐºÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ¾Ð¼ Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð¸Ð¹ (ÐÐÐ) Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð° â Ð½Ð¸Ð·ÐºÐ¾Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ ÑÐ»Ð°Ð´Ð¾ÑÑÐ¾Ð¹ÐºÐ¾Ð¹ ÑÑÐ°Ð»Ð¸. Ð­ÑÐ¾ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ð»Ð¾ ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°ÑÑ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ðº Ð²ÐµÐ»Ð¸ÑÐ¸Ð½Ðµ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐ½Ð¾Ð³Ð¾ Ð·Ð°Ð¿Ð°ÑÐ° Ð¿Ð¾ Ð´Ð°Ð½Ð½Ð¾Ð¼Ñ Ð²Ð¸Ð´Ñ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ð¹ Ð¿Ð¾ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ Ðº Ð¼Ð¸Ð½Ð¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐµ Ð¿ÑÐ¸Ð¼ÐµÐ½Ð¸Ð¼Ð¾ÑÑÐ¸. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¸ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ Ð¿Ð¾Ð½ÑÑÐ¸Ñ Ð¸ Ð·Ð°Ð´Ð°ÑÐ¸, Ð¾ÑÐ½Ð¾ÑÑÑÐ¸ÐµÑÑ Ðº ÑÑÐµÑÐµ ÑÐ°Ð±Ð¾ÑÑ. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ñ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ñ, ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÐºÐ¾ÑÐ¾ÑÑÑ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ´Ð¸Ð»Ð¸ ÑÑÐµÐ±ÑÐµÐ¼ÑÑ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÑ NDT Ð¸ Ð¿Ð¾Ð¼Ð¾Ð³Ð»Ð¸ Ð²Ð½ÐµÑÑÐ¸ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÑ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ñ. Ð¢Ð°ÐºÐ¶Ðµ Ð½Ð°Ð¼ÐµÑÐµÐ½ Ð¿Ð»Ð°Ð½ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð¼Ñ Ð²Ð¾Ð¿ÑÐ¾ÑÑ.
description: The relationship between the nil-ductility temperature (NDT) and the critical stress intensity factor (SIF) of the low-alloy cold-resistant steels was established in the proposed research with using FEM calculations. This allowed to formulate requirements for the value of the temperature reserve for the given type of test in relation to the minimum design temperature. Related to the field of research concepts and tasks were analyzed and presented. The mechanical tests were performed, the results of which confirmed the required NDT temperature and helped to make changes to the test procedure. A plan for further researches on the above issue is also outlined.
Niddah 2.0: Jewish Menstrual Purity in the Internet Age
Creators: name: Lis, Ariella
Publisher: name: Brandeis University
Year: 2011
Subjects: Jewish menstrual purity ritual
Niddah
Orthodox Jews

description: This thesis analyzes web based tools created by the Orthodox Jewish community to support women in their observance of Jewish menstrual purity ritual practice (JMPR).
On the Bott periodicity.
Creators: name: Chang, Sun-Man.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1970
Subjects: subject: Mathematics.

description: In this thesis we first introduce K-theory. Then we present the formulation of the Bott periodicity of the homotopy groups of the infinite unitary group in the framework of K-theory. Finally we prove the equivalence of this K-theory formulation with the original one given by Bott.
Water politics in Victoria: The impact of legislative design, policy objectives and institutional constraints on rural water supply governance
Creators: name: Rankin, Benjamin David
Publisher: name: Swinburne
Year: 2024

description: The thesis considers the development of legislative and administrative structures for Victorian rural water governance, and how their origins constrained the institutional development of water supply policy thereafter. It is focused on the self-reinforcing nature of policy choices and understanding how subsequent decision makers are influenced by the cultures, norms and practices that are unique to the institution. It offers the first comprehensive account of how the institutional structure concerning rural water supply governance in Victoria influenced the evolution of policy. Through this analysis, it offers an important insight into many issues concerning the ongoing water policy debate in Australia.
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¸Ð½Ð´ÑÑÑÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¼Ð°ÑÐµÐ» Ñ ÑÐ³Ð»ÐµÑÐ¾Ð´Ð½ÑÐ¼ Ð½Ð°Ð½Ð¾Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Research of industrial oil with carbon nanomodifier
Creators: name: ÐÑÐ½Ð½Ð¸Ðº, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð½Ð°Ð½Ð¾Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾Ñ
Ð¸Ð½Ð´ÑÑÑÑÐ¸Ð°Ð»ÑÐ½Ð¾Ðµ Ð¼Ð°ÑÐ»Ð¾
Ð³Ð»Ð¾Ð±ÑÐ»ÑÑÐ½ÑÐ¹ ÑÐ³Ð»ÐµÑÐ¾Ð´
Ð»Ð¸Ð½ÐµÐ¹Ð½ÑÐ¹ Ð¸Ð·Ð½Ð¾Ñ
ÑÐ°Ð·Ð¼ÐµÑÐ½ÑÐ¹ Ð¸Ð·Ð½Ð¾Ñ
nanomodifier
Industrial oil
globular carbon
linear wear
dimensional wear

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ, Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÐ¼Ð¾Ð³Ð¾ Ð´Ð¾Ð±Ð°Ð²ÐºÐ¾Ð¹ Ð² ÑÐ¼Ð°Ð·Ð¾ÑÐ½ÑÐ¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð» (Ð¸Ð½Ð´ÑÑÑÑÐ¸Ð°Ð»ÑÐ½Ð¾Ðµ Ð¼Ð°ÑÐ»Ð¾ Ð20Ð) Ð½Ð°Ð½Ð¾Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ° (Ð³Ð»Ð¾Ð±ÑÐ»ÑÑÐ½ÑÐ¹ ÑÐ³Ð»ÐµÑÐ¾Ð´), Ð½Ð° Ð¸Ð·Ð½Ð¾Ñ Ð¾Ð±ÑÐ°Ð·ÑÐ°. ÐÐ°Ð´Ð°ÑÐ¸, ÑÐµÑÐ°ÐµÐ¼ÑÐµ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐµ ÑÐ°Ð±Ð¾ÑÑ: 1. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐ¿Ð¾ÑÐ¾Ð±Ð¾Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸Ð½Ð´ÑÑÑÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¼Ð°ÑÐµÐ». 2. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ÑÑÐ¸Ð±Ð¾ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ð¹ Ð´Ð²ÑÑ ÑÐ¸Ð¿Ð¾Ð² Ñ Ð±Ð°Ð·Ð¾Ð²ÑÐ¼ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐ¼ ÑÐ¼Ð°Ð·Ð¾ÑÐ½ÑÐ¼Ð¸ ÑÐ¾ÑÑÐ°Ð²Ð°Ð¼Ð¸ Ð¿ÑÐ¸ Ð·Ð°Ð´Ð°Ð½Ð½ÑÑ ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ð¹. 3. Ð¡ÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð´Ð»Ñ ÑÐ¾ÑÑÐ°Ð²Ð¾Ð² Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÐÐ£Ð Ñ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐ¼Ð¸ Ð´Ð»Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð° Ð±ÐµÐ· Ð¿ÑÐ¸Ð¼ÐµÑÐµÐ¹. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð°Ð½Ð¾ÑÐ³Ð»ÐµÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ° Ð½Ð° Ð¸Ð·Ð½Ð¾Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð°. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð° ÑÐµÐ»ÐµÑÐ¾Ð¾Ð±ÑÐ°Ð·Ð½Ð¾ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð´Ð¾Ð±Ð°Ð²ÐºÐ¸.
description: This work is devoted to the study of the effect exerted by the addition of a nanomodifier (globular carbon) to a lubricant (industrial oil I20A) on the wear of the sample. Tasks to be solved in the process of work: 1. The study of various methods of industrial oils research. 2. Conducting tribotechnical tests of two types with basic and experimental lubricants under specified test conditions. 3. Comparison of the data obtained for compositions with the addition of NUM with the data obtained for a material without impurities. As a result, the effect of the nanocarbon modifier on the wear of the material was analyzed. The expediency of using this additive is considered.
title: Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients
title: a retrospective cohort study
titleType: Subtitle
Creators: name: Koelzer, Viktor H.
name: Herrmann, Pia
name: Zlobec, Inti
name: Karamitopoulou, Eva
name: Lugli, Alessandro
name: Stein, Ulrike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: MACC1
subject: Biomarker
subject: Tumor budding
subject: Colorectal cancer
subject: Prognostic factor
subject: Metastasis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as metastasis inducer and prognostic biomarker. Here, we investigate the geographic expression pattern of MACC1 in colorectal adenocarcinoma and tumor buds in correlation with clinicopathological and molecular features for improvement of survival prognosis. Methods We performed geographic MACC1 expression analysis in tumor center, invasive front and tumor buds on whole tissue sections of 187 well-characterized CRCs by immunohistochemistry. MACC1 expression in each geographic zone was analyzed with Mismatch repair (MMR)-status, BRAF/KRAS- mutations and CpG-island methylation. Results MACC1 was significantly overexpressed in tumor tissue as compared to normal mucosa (p
Characterizations of Inflammasomes During Infection in Macrophages
Creators: name: Kharbanda, Vritti
Publisher: name: Brandeis University
Year: 2022
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Microbiology
subject: FOS: Biological sciences

description: The innate immune response fights off pathogen invasion of the host, independent of previous exposure. The formation of inflammasomes, which are a multiprotein complex, ultimately leads to cell death. There are two inflammasome complexes in macrophages upon infection: the canonical and noncanonical inflammasome. We tested whether ASC speck formation, an indication of the canonical inflammasome, can be detected in Shigella infected and COVID-19 infected macrophages through western blots and immunofluorescence assays. We also tested whether TRAF6, a protein involved in innate immune signaling pathways, modulates non-canonical inflammasome formation through western blots and cytotoxicity assays. Additionally, we tested if priming with IFNγ- a cytokine- can stimulate non-canonical inflammasome formation in the absence of the sensor protein through western blots and cytotoxicity assays. We found that ASC specks could be detected in either Shigella or COVID-19 infected cells. Furthermore, TRAF6 does not modulate the noncanonical inflammasome and IFNγ stimulation cannot stimulate the noncanonical pathway in the absence of the sensor protein.
Investigation of the virus-host cell interactions involved in reovirus inclusion formation.
Creators: name: Mbisa, Jean Lutamyo.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Microbiology.

description: Reovirus has a segmented dsRNA genome enclosed in a nonenveloped double capsid shell. Reovirus infection induces the formation of large cytoplasmic inclusions that serve as the major site for viral assembly. These inclusions contain the intermediate filament vimentin, in addition to viral proteins, RNA, mature and immature viral particles. However, the viral or host proteins involved in the formation of reovirus inclusions have not been identified, neither has the mechanism by which viral RNA and proteins are directed to these sites. In this study the reovirus M1 gene, which encodes the minor core protein mu2, was identified as the primary determinant of the rate of inclusion formation. Cellular localization studies of mu2 protein in cells infected with wild-type or ts mutants of reovirus as well as in M1 gene-transfected cells showed that mu2 protein may directly be involved in inclusion formation. Expression of mu2 protein in infected cells was shown to be strain-dependent with type 1 strain "Lang" (T1L) producing significantly more mu2 protein than type 3 strain "Dearing" (T3D). Protein stability was demonstrated to be partly responsible for the difference in mu2 protein expression between T1L and T3D, with T1Lmu2 being more stable than T3D mu2. Degradation of mu2 protein was shown to occur via the ubiquitin-proteasome pathway (UPP). Ubiquitinated mu2 protein was present in reovirus inclusions together with components of the UPP making reovirus inclusions structurally similar to aggresomes and suggesting that reovirus may be using the UPP and aggresome formation pathway for inclusion formation. In keeping with this theory, it is shown that both reovirus inclusion formation and replication are inhibited when the cellular pool of free ubiquitin (Ub) is depleted by using proteasome inhibitor and that replication maybe enhanced by mono-ubiquitination. Interestingly, the most abundant ubiquitinated mu2 protein species was mono-ubiquitinated mu2 suggesting a role for mono-ubiquitinated mu2 in reovirus inclusion formation and viral assembly. In addition, the amino-terminal end of recombinant mu2 protein, which contains a potential E3 Ub-ligase motif, was shown to be important for protein complex formation. Most importantly reovirus inclusions, like aggresomes, were shown to impair the normal functioning of the UPP resulting in inhibition of Ub-dependent proteolysis which presumably contributes to cytopathology and disease in infected animals. This study is the first to show the use of the UPP in the replication of a nonenveloped or dsRNA virus.
Hoarding disorder: current treatment and future directions
Creators: name: Fitzpatrick, Molly Anne
Publisher: name: Swinburne
Year: 2024

description: Hoarding disorder is a disabling condition experienced within the population. It is characterized by the accumulation, and/or excessive acquisition of belongings and a difficulty discarding these possessions. Treatment for hoarding has focused on cognitive behavior therapy, in addition to pharmacological interventions and bibliotherapy. Our overall findings highlight various strengths and weaknesses. Although treatment outcome studies appear to have high efficacy, there are a range of limitations including a majority of participants remaining symptomatic post-treatment, and questions around the sustainability of treatment effects. Additional research may enable the potential for innovation and advancement of our existing treatment structures.
Synchronicity and poststructuralism: C. G. Jung's secularization of the supramundane.
Creators: name: Clark, Michael William.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Religion, Philosophy of.

description: The thesis argues that the ideological content of C. G. Jung's concept of synchronicity and particularly Jung's method of presenting synchronicity from 1928-1961 prefigure aspects of Michel Foucault's postmodern thought. Part 1 discusses issues of theory and method. Part 2 analyzes the various asides which Jung makes about synchronicity from 1928-1951, prior to his three formal works about synchronicity: "On Synchronicity" (1951); The Interpretation of Nature and the Psyche (with Wolfgang Pauli, 1952); and Synchronicity: An Acausal Connecting Principle (1952). Part 3 analyzes these formal works about synchronicity, as well as Jung's comments on synchronicity from 1953 to the time of his death in 1961. The primary method of Parts 2 and 3 is Michel Foucault's discourse analysis, as outlined in The Archaeology of Knowledge (1972). Part 4 critically compares Jung's concept of synchronicity to Foucault's later understanding of discourse theory, as described in Power/Knowledge (1972). This comparison explores the truth claims forwarded by each theorist among the analytical categories of knowledge, power, and subjectivity. I conclude that the concept of synchronicity and Jung's presentation of synchronicity prefigure a postmodern approach to theory and practice. Jung and Foucault both posit the ideas of (1) an intimate connection between the internal image and the external world (2) acausality and discontinuity (3) the relativity of truth, and (4) the fallacy of "objectivity." But Jung's contradictory belief in a transhistorical, absolute dimension to the self differs from Foucault's view that subjectivity is relative to the social discourses and discursive practices which create it. I also infer that Jung purposely legitimizes synchronicity with a postmodern style of argumentation because he is aware of the need to implement a "new" truth in an unreceptive social environment. The idea of the relativity of space and time which is explicit to synchronicity is not widespread and, in fact, quite foreign to the weltanschauung of the early to middle twentieth century--particularly in Jung's field of medicine. Regarding the heuristic value of synchronicity, several theorists use the concept to advance ideas about (1) the paranormal and (2) an anticipated paradigm shift of global consciousness, characterized by beliefs about the relativity of space and time and particularly by the idea that all thoughts, actions, and objects are essentially interconnected.
Aerobic training and hydroalcoholic extracts of green tea improve pro-oxidant-antioxidant balance and histopathological score in the N-methyl-N-nitrosourea–induced prostate cancer model of rat
Creators: name: Vahabzadeh, Zakaria
name: Molodi, Mohammadraman
name: Nikkho, Bahram
name: Saghebjoo, Marziyeh
name: Saedmocheshi, Saber
name: Zamani, Fatemeh
name: Roshani, Yazdan
name: Babanzadeh, Sina
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: prostate cancer
pro-oxidant-antioxidant balance
prostate-specific antigen
Camellia sinensis
aerobic exercise

description: Green tea is a main resource for catechins. Catechins as antioxidant compounds reduce the production of reactive oxygen species and they have a protective role in the development of cancer. As well as, aerobic exercise change free radicals with two contradictory mechanisms. Aerobic training promotes excessive production of free radicals resulting in oxidative stress. In contrast, it increases the total antioxidant capacity. In this study, effect of aerobic training and hydroalcoholic extract of green tea (HEGT) on the pro-oxidant-antioxidant balance (PAB), prostate-specific antigen (PSA) and histopathological score of cancerous tissue in the N-methyl-N-nitrosourea–induced prostate cancer was investigated. A rat model of prostate cancer was induced by hormonal change and N-Nitroso-N-methylurea (NMU). HEGT 0.1 % and 45 min of aerobic exercise in 5 days a week for eight weeks were scheduled. The presence of major catechins was approved using GC-MS. Histological study, PAB and PSA levels were used to monitor the preventive role of treatments. The prostate weights of cancerous rats were significantly higher than healthy controls (P<0.05). The PAB was only significantly higher in cancerous rats and cancerous rats receiving aerobic exercise (P<0.05). The mean of histological score of cancerous tissue was reduced in rat receiving HEGT and both HEGT and aerobic exercise. The amounts of PSA level did not significantly differ between the groups of this study (P>0.05). Our results provided laboratory and histological documentation for the preventive role of green tea extract in developing prostate cancer via its potential to re-establish the pro-oxidant-antioxidant balance.
description: EXCLI Journal; 19:Doc762; ISSN 1611-2156
Wielding Care: Democracy, Injustice, and Obligation
Creators: name: Robbins, Holly E
Publisher: name: Brandeis University
Year: 2023
Subjects: Care Ethics
Injustice
Joan Tronto
Judith Shklar
Justice
Political Obligation

description: What we owe one another as individuals and citizens, and what governments owe to us, has long been the subject of vigorous debate. This dissertation seeks to provide a novel intervention into that conversation by integrating the works of Judith Shklar with care ethics. In so doing, it explores the role of relationships, virtues and vices, injustice, the utility and danger of power, and liberal democracy in our quest to prevent and respond to suffering. Although we all recognize injustice around us and all require care, theorists often eschew focusing directly on these concerns, instead subsuming them within or curtailing them as outside other frameworks. This dissertation argues that integrating Shklar and care ethics provides a novel path to developing a theory of obligation that can serve as an alternative to more ideal theories, such as Rawls’ or Mill’s. However, its intent is not to provide such an alternative, but to open a discussion on what Shklar and care ethics, two often parochialized literatures, in concert have to say to the broader discipline.
Les stratégies de développement : fondement des désiquilibres socio-économiques et politiques : le cas du Zaïre.
Creators: name: Mukandila, Malu B.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Political Science, General.

description: Cette these sur les strategies de developpement comme fondement des desequilibres socio-economiques et politiques u Zaire s'inscrit dans un ensemble des recherches faites depuis les annees soixante-dix et quatre-vingt, sur la crise economique du Zaire. Notre preoccupation majeure est d'echapper a une analyse conjoncturelle, en mettant l'accent sur le changement et les mutations d'un systeme socio-economique donne, les contradictions et les continuites de ce sous-systeme dans une optique historique, c'est-a-dire depuis la colonisation et d'en suivre la trame jusqu'a date, c'est-a-dire les annees 90. En choisissant de faire une telle analyse, nous avons voulu demontrer que plusieurs analyses sur la crise zairoise actuelle ne posent pas le probleme dans son ensemble; tantot les etudes brandissent des arguments imputants la responsabilite a l'imperialisme, tantot aux dirigeants nationaux et a leur incapacite de gouverner. On ne semble pas regrouper ces deux explications dans une analyse globale. Plusieurs chercheurs semblent aujourd'hui negliger de prendre en consideration la notion de dualite economique et de domination comme facteurs determinant de l'evolution des economies africaines post-independantes dans l'economie-monde. Ceci ne signifie pas que notre these soit basee sur ces deux notions; loin s'en faut. Cependant, nous pensons que ces deux notions sont plus que jamais un revelateur analytique fondamental dans l'analyse des crises actuelles a la peripherie africaine. En outre, il serait ironique de recuser egalement la notion de la dependance et de croire que les pays africains pouvaient connai tre un developpment economique dans le contexte des dependances multiples auxquelles ils font face sur la scene mondiale. (Abstract shortened by UMI.)
Peering Down the Rabbit Hole: Living with von Hippel-Lindau Syndrome from the Young Adult Perspective
Creators: name: Schmidt, Lindsay
Publisher: name: Brandeis University
Year: 2015
Subjects: von Hippel-Lindau syndrome (VHL)
Young adults
Psychosocial
Uncertainty
Positive attitude
Support
Relationships
Life decisions
Childbearing
Genetic counseling

description: Von Hippel-Lindau syndrome (VHL) is a highly penetrant cancer susceptibility syndrome that requires rigorous surveillance and often involves surgery to remove VHL-related tumors throughout the body. Few studies have explored the psychosocial aspects of living with VHL and there is a lack of literature addressing the psychosocial challenges that young adults with VHL face as they encounter various transitions in their lives. To address this gap in the literature, this study focused on a cohort of ten young adults (18-26 years old) with VHL, whom all reside in the United States. All participants were recruited through the VHL Alliance. Semi-structured telephone interviews were conducted with each participant to gain an understanding of the experience of living with VHL as a young adult. The major topics that were addressed included personal and familial experiences with VHL, support systems, emotional well-being, the effect of VHL on romantic and familial relationships, and the effect of VHL on life decisions. Thematic analysis of the interview transcripts was performed in ATLAS.ti (v.7.5.4) and five themes were identified: (1) living with uncertainty, (2) maintaining a positive attitude, (3) significant means of support, (4) polarizing effect on relationships, and (5) impact on life decisions with respect to location, career path, and childbearing. These themes indicate that living with VHL as a young adult involves a considerable psychosocial component that extends beyond the well-studied physical aspects of the syndrome. Young adults with VHL would likely benefit from establishing a long-term relationship with a genetic counselor. Genetic counselors can help manage uncertainty, connect patients with other young adults living with VHL, and provide education regarding childbearing options. Further research with this population will likely help genetic counselors and other health professionals who care for VHL patients to provide better support and services to young adults living with VHL.
An Investigation into Self-Care and Compassion Fatigue Among Genetic Counselors
Creators: name: Hornung, Holly
Publisher: name: Brandeis University
Year: 2013
Subjects: Genetic Counselor Compassion Fatigue
Social Readjustment
Self-Care
Stress
Burnout

description: Genetic counselors are susceptible to compassion fatigue, defined as feelings of anger, depression, or apathy felt by an individual as a result of being exposed to the trauma or suffering of another. The caregiving nature of the genetic counseling profession puts individuals in direct contact with patients dealing with difficult diagnoses and often traumatic life experiences. Previous research has demonstrated that hospice workers who engage in self-care activities experience lower levels of compassion fatigue. The purpose of this study was to investigate whether self-care methods are correlated with lower levels of compassion fatigue among genetic counselors. We recruited genetic counselors through the National Society of Genetic Counselors (NSGC) listserv for participation in an anonymous, online survey, which assessed respondents’ perceived levels of stress and compassion fatigue and the frequency with which they have participated in a number of self-care activities. Of the 301 genetic counselors who responded to the survey, 185 (62%) reported moderate levels of compassion fatigue. The distribution of respondents’ work settings differed from that seen in the NSGC professional status survey, with a greater proportion of non-clinical counselors, and a smaller proportion of prenatal counselors. Not surprisingly, respondents who reported higher levels of stress also reported higher levels of compassion fatigue. Self-care methods that were significantly correlated with lower compassion fatigue scores included receiving supervision; reading literature unrelated to genetic counseling; chatting with coworkers; setting limits with patients and colleagues; and striving for balance among work, family, relationships, rest, and play.
Development of Novel Molecular Photoswitches for Their Applications in Photon Energy Storage and Catalyst Recovery
Creators: name: Qiu, Qianfeng
Publisher: name: Brandeis University
Year: 2024

description: Molecular photoswitches are molecules that undergo reversible isomerization upon exposure to different wavelengths of light. Isomerization induces changes in the molecular structures and configurations, resulting in significant variations in physical and chemical properties, including polarity, absorption, energy state, phase, and solubility. Consequently, the materials incorporating novel molecular switches hold promise for a wide range of applications including energy storage, drug delivery, sensing, optical memory, and recovery of high-value chemicals, among others. This thesis focuses on functionalizing two categories of photoswitches: azo derivatives and hydrazones, to meticulously modify their properties for applications in molecular solar thermal energy storage and catalyst recovery. The first part of this thesis aims to develop ideal materials featuring condensed phase isomerization, long energy storage times, reversible visible light activation, large energy storage, and phase transition for solar thermal energy storage. Strategies for functionalizing the photoswitches are developed, and their optical and thermal properties are investigated. Inspired by the solid-liquid phase transition of photoswitches, which indicates significant variation in the polarity and interactions of molecules upon light absorption, I explore the optical control over the solubility of photoswitches in organic solvents. The second part of my thesis focuses on the integration of photoswitches in catalyst structures to adjust their solubility in solvents and facilitate their recovery after catalysis. This approach enables the reversible dissolution and precipitation of the catalysts upon light stimulation, which allows us to harness the high activity of homogenized catalysts and the easy recovery of precipitated catalysts. This thesis aims to provide a comprehensive view of molecular photoswitches’ properties in solution and solid state, as well as their applications in various areas of research.