cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cooling electrons in nanoelectronic devices by on-chip demagnetisation
Creators: name: Jones, Alexander
Publisher: name: Lancaster University
Year: 2019

description: This thesis describes a novel cooling technique which allows the electrons within nanoelectronic devices to reach new low temperatures: nuclear demagnetisation of copper refrigerant mounted directly onto the chip a device is constructed on. This is within a field which has expanded in interest in recent years, due to the promise of new low electron temperatures allowing the investigation of new physical phenomena, the better fidelity of fundamental quantum effects and the improvement in quantum technologies such as quantum computers and sensors. Throughout the study, the effectiveness of the new technique is verified by applying it to a CBT, a nanoelectronic device which provides primary (accurate without any need for calibration) thermometry of its own internal electron temperature. This thesis follows the development of this technique, starting from the initial proof of concept measurements made using a commercial, cryogen free, dilution refrigerator, as would be found in many low temperature and quantum transport laboratories. Here, the device electrons were cooled from 7 mK, the base temperature of the dilution refrigerator, to 4.5 mK without using any other elaborate experimental constructions, opening the technique up to many other laboratories. This technique was then furthered by applying it to a newly adapted CBT which has the lowest operation temperature capability yet reported of 300 μK. This was done in a dilution refrigerator custom built in Lancaster, resulting in a minimum electron temperature of 1.20 ± 0.03 mK. This has opened the door to a new temperature regime in which to study new quantum effects, and going forward this technique will therefore be applied to other devices in order to enable these further investigations.
Self-Trapping of G-Mode Oscillations in Relativistic Thin Disks, Revisited
Creators: name: Kato, Shoji
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We examine by a perturbation method how the self-trapping of g-mode oscillations in geometrically thin relativistic disks is affected by uniform vertical magnetic fields. Disks which we consider are isothermal in the vertical direction, but are truncated at a certain height by presence of hot coronae. We find that the characteristics of self-trapping of axisymmetric g-mode oscillations in non-magnetized disks is kept unchanged in magnetized disks at least till a strength of the fields, depending on vertical thickness of disks. These magnetic fields become stronger as the disk becomes thinner. This result suggests that trapped g-mode oscillations still remain as one of possible candidates of quasi-periodic oscillations observed in black-hole and neutron-star X-ray binaries in the cases where vertical magnetic fields in disks are weak.
description: 8 pages, 2 figures
Additional file 1: Figure A1. of The implementation of academic detailing and its effectiveness on appropriate prescribing of pain relief medication: a real-world cluster randomized trial in Belgian general practices
Creators: name: Bruyndonckx, Robin
name: Verhoeven, Veronique
name: Anthierens, Sibyl
name: Cornelis, Koen
name: Ackaert, Katelijne
name: Gielen, Birgit
name: Coenen, Samuel
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Information package on appropriate use of pain relief medication in patients with osteoarthritis used by the academic detailer (PDF 1229 kb)
title: ADCO, Grènetier de Cîteaux : comptes (1499-1503) (11 H 1173), f. 00337
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173), f. 00337, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Characterizing the ISM using Fine-Structure Lines in a z=5.7 Hyper-Starburst Galaxy Merger
Creators: name: Litke, Katrina
Publisher: name: Zenodo
Year: 2020

description: SPT0346-52 is a gravitationally lensed dusty star-forming galaxy at z~5.7 from the South Pole Telescope sample1. It is an extremely luminous hyper-starburst system with intrinsic far-infrared luminosity > 1013 Lsun and star formation rate density ~4200 Msun yr-1 kpc2. Based on ALMA observations of [CII]158 emission, we have determined the prodigious star formation rate density is likely driven by a major merger of two components. Continuing this work, we have ALMA Bands 6 and 7 observations of four fine structure lines in this dusty starforming galaxy: [CII]158, [OI]145, [NII]205, [NII]122. We use a pixelated, interferometric lensing reconstruction code to model the visibilities observed by ALMA and "de-lens" emission to obtain the spatially resolved interstellar medium (ISM) in the source-plane.
Substituted benzophenone synthesis for biological and catalytic applications
Creators: name: Moore, Alexander Franklin
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The benzophenone (BP) synthon has been shown to be a powerful functionality for an array of applications in biology and catalysis, owing to its unique biaryl twist and diradicaloid triplet state upon photo-­‐excitation. In this work, synthesis of the BP synthon and derivatives will be investigated as they could be potential new biological binding moieties and also photocatalytic motifs. The natural product (−) ­‐Balanol, is a potent Protein Kinase C (PKC) inhibitor that contains the BP synthon. Synthesis of substituted BPs will be examined in order to find new motifs for probing the active site of PKC with enhanced isozyme specificity. Likewise, following previous work involving a chiral trifunctional organocatalyst synthesis of a catalyst with a BP motif will be investigated for its future catalytic applications.
MOESM1 of RNA-guided single/double gene repressions in Corynebacterium glutamicum using an efficient CRISPR interference and its application to industrial strain
Creators: name: Jaehyun Park
name: Hyojung Shin
name: Lee, Sun-Mi
name: Youngsoon Um
name: Woo, Han
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Additional file 1: Table S1. Oligonucleotides used for gene cloning in this study. Table S2. Oligonucleotides used for RT-PCR and qRT-PCR in this study. Figure S1. Gel images of Fig.Â 2. Figure S2. Gel images of Fig.Â 4. Figure S3. Relative mRNA expression and phenotype analysis of single gene repressions in C. glutamicum strains for the double gene repression study. Figure S4. Relative mRNA expression and phenotype analysis of double gene repressions in C. glutamicum strains.
Chiral pair fluctuations for the inhomogeneous chiral transition
Creators: name: Yoshiike, Ryo
name: Lee, Tong-Gyu
name: Tatsumi, Toshitaka
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The effects of fluctuations are discussed around the phase boundary of the inhomogeneous chiral transition between the inhomogeneous chiral phase and the chiral-restored phase. The particular roles of thermal and quantum fluctuations are elucidated and a continuity of their effects across the phase boundary is suggested. In addition, it is argued that anomalies in the thermodynamic quantities should have phenomenological implications for the inhomogeneous chiral transition. Some common features for other phase transitions, such as those from the normal to the inhomogeneous Fulde-Ferrell-Larkin-Ovchinnikov state in superconductivity, are also emphasized.
description: 16 pages, 2 figures
Additional file 7 of Genome-wide association study of the candidate genes for grape berry shape-related traits
Creators: name: Zhang, Chuan
name: Cui, Liwen
name: Fang, Jinggui
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7: Table S3. The variation in different berry shape parameters.
An empirical investigation into asset allocation strategies: an Australian perspective
Creators: name: Joubaili, Abdel Karim
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Optimisation models developed since the development of modern portfolio theory diverge mainly in their approaches to the estimation mechanics of asset returns and risk parameters. The original structure of modern portfolio theory employs the estimates of the first two moments of returns, namely the mean and variance, in the optimisation algorithm. Critics of modern portfolio theory base their arguments on the fact that statistical estimates of the input parameters, namely return and risk, are subject to estimation error. As a result, the output of the modern portfolio theory optimisation model is usually unstable with counterintuitive portfolio weights. This has provoked ample research fixated on addressing those limitations by using various econometric and mathematical techniques. This research addresses two issues that constitute the crux of deliberations on portfolio choice problems. The first is the moments estimation mechanics and its effect on portfolio optimisation in a static framework. The other is the asset returns predictability and its employment in dynamic asset allocation strategies. In both cases, the performance of the portfolio optimisation rules is compared with the performance of the naïve allocation as a benchmark. This is because recent empirical evidence has highlighted the supremacy of naïve allocation over statistically driven optimisation strategies. This thesis forms an empirical investigation of the asset allocation models that appeared in the financial literature throughout the past few decades. This thesis first delves into the weaknesses and strengths of each of the optimisation theories suggestedin the financial literature, and then extends some of the optimisation theories into novel approaches. In essence, the core of this research is an investigation of the effcient market hypothesis and the effectiveness of asset returns predictability. This research endeavor is significant, first because of its empirical scrutiny of asset allocation strategies, vigorous analysis and robustness checks of those asset allocation strategies under several risk and returns configurations, and second because of its consideration of static optimisation models versus dynamic allocation techniques.
MOESM1 of Host-specific differences in the response of cultured macrophages to Campylobacter jejuni capsule and O-methyl phosphoramidate mutants
Creators: name: Sungwon Kim
name: Vela, Andrea
name: Clohisey, Sara
name: Athanasiadou, Spiridoula
name: Kaiser, Pete
name: Stevens, Mark
name: Vervelde, Lonneke
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Campylobacter jejuni capsule and MeOPN mutants elicit an enhanced cytokine responses in mBMDCs. The mBMDCs were differentiated from vials of frozen C57BL/6 mouse bone marrow following the protocol of Rose et al. [31] in the presence of GM-CSF (final concentration of 20 ng/mL; Peptro Tech) for 7 days. Live or fixed C. jejuni 11168H (WT), Δcj1417 (MeOPN) and Δcj1439 (capsule) mutants were incubated with mBMDCs at MOI 50 for 3 h. Salmonella LPS was used as a positive control, while PBS in the medium was used as a negative control. Graphs show representative results of two independent experiments. Error bars are the standard deviation of two independent experiments. Asterisks indicate a statistically significant difference of mRNA levels of inflammatory-related cytokines compared to C. jejuni WT (*P
Integrative statistical methods for the genomic analysis of immune-mediated disease
Creators: name: Burren, Oliver Simon
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: genomics
subject: statistics
subject: autoimmunity
subject: immunology

description: Genome-wide association studies (GWAS) have proved to be a successful method in cataloguing loci influencing thousands of complex human disease phenotypes. However, elucidating the causal mechanisms underlying such associations has proved challenging due to the regulatory nature of the majority of signals. In Chapters 2 and 3, I hypothesised that promoter-capture Hi-C (PCHi-C) data might have utility in physically linking disease-associated regulatory variants to their target genes, in a tissue-specific manner. To examine the genome-wide enrichment of GWAS summary statistics within PCHi-C chromatin contact maps I developed a novel statistical method, blockshifter. I applied \textit{blockshifter} to a compendium of GWAS summary statistics for 31 traits and PCHi-C data across 17 primary blood tissues, and found convincing evidence for the enrichment of immune-mediated disease (IMD) GWAS signals in lymphocyte-specific chromatin interactions, providing support for the hypothesis. Taking a more gene-centric approach I developed `COGS', a novel method for integrating GWAS and PCHi-C to prioritise specific causal variants, genes and cellular contexts for functional follow up. With a focus on IMD, I prioritised tissue-context specific interactions in CD4$^{+}$ T cells linking putative causal variants for type 1 diabetes, to the promoter of IL2RA. The effect of these variants on IL2RA expression was subsequently validated by allele-specific expression, by a collaborator, supporting the approach. In Chapter 4, I hypothesised that summary statistics from multiple, well-powered GWAS of related diseases might be exploited to provide insight into rarer related diseases or disease subtypes. To investigate this I developed a PCA based framework to generate a lower-dimensional basis, summarising input GWAS traits. I constructed such a basis from ten IMD GWAS studies, excluding variants in the HLA region, and projected on summary GWAS data from multiple sources in order to characterise individual principal components (PCs). By projecting on both summary and individual-level genotype data for juvenile idiopathic disease subtypes, I was able to show that a single PC was able to discriminate enthesitis-related and systemic forms of the disease from other subtypes.
Stability of sulphur dimers S2 in cometary ices
Creators: name: Mousis, O.
name: Ozgurel, O.
name: Lunine, J. I.
name: Luspay-Kuti, A.
name: Ronnet, T.
name: Pauzat, F.
name: Markovits, A.
name: Ellinger, Y.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: S2 has been observed for decades in comets, including comet 67P/Churyumov-Gerasimenko. Despite the fact that this molecule appears ubiquitous in these bodies, the nature of its source remains unknown. In this study, we assume that S2 is formed by irradiation (photolysis and/or radiolysis) of S-bearing molecules embedded in the icy grain precursors of comets, and that the cosmic ray flux simultaneously creates voids in ices within which the produced molecules can accumulate. We investigate the stability of S2 molecules in such cavities, assuming that the surrounding ice is made of H2S or H2O. We show that the stabilization energy of S2 molecules in such voids is close to that of the H2O ice binding energy, implying that they can only leave the icy matrix when this latter sublimates. Because S2 has a short lifetime in the vapor phase, we derive that its formation in grains via irradiation must occur only in low density environments such as the ISM or the upper layers of the protosolar nebula, where the local temperature is extremely low. In the first case, comets would have agglomerated from icy grains that remained pristine when entering the nebula. In the second case, comets would have agglomerated from icy grains condensed in the protosolar nebula and that would have been efficiently irradiated during their turbulent transport towards the upper layers of the disk. Both scenarios are found consistent with the presence of molecular oxygen in comets.
description: Accepted for publication in The Astrophysical Journal
title: 01_2302
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Breast cancer-related mortality in Central and Eastern Europe: years of life lost and productivity costs
Creators: name: Bencina, Goran
name: Chami, Nour
name: Hughes, Robert
name: Weston, Georgie
name: Baxter, Carl
name: Maciejczyk, Adam
name: Popovic, Lazar
name: Karamousouli, Eugenia
name: Salomonsson, Stina
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Breast cancer (BC) poses a public health challenge as the most commonly diagnosed cancer among women globally. While BC mortality has declined across Europe in the past three decades, an opposite trend has been reported in some transitional European countries. This analysis estimates the mortality burden and the cost of lost productivity due to BC deaths in nine Central and Eastern Europe (CEE) countries: Bulgaria, Croatia, Czech Republic, Hungary, Poland, Romania, Serbia, Slovakia, and Slovenia, that have defied the favorable cancer mortality trends. These estimates may provide relevant evidence to aid decision-makers in the prioritization of BC-targeted policies. The human capital approach (HCA) was used to estimate years of life lost (YLL) and productivity losses due to premature death from BC (ICD-10 code: C50 Malignant neoplasm of breast). YLL and present value of future lost productivity (PVFLP) were calculated using age and gender-specific mortality, wages, and employment rates. Data were sourced from the World Health Organization (WHO), Eurostat, and the World Bank. In 2019, there were 19,726 BC deaths in the nine CEE countries. This study estimated BC deaths resulted in 267,184 YLL. Annual PVFLP was estimated to be €85 M in Poland, €46 M in Romania, €39 M in Hungary, €21 M in Slovakia, €18 M in Serbia, €16 M in Czech Republic, €15 M in Bulgaria, €13 M in Croatia, and €7 M in Slovenia. Premature death from BC leads to substantial YLL and productivity losses. Lost productivity costs due to premature BC-related mortality exceeded €259 million in 2019 alone. The data modeled provide important evidence toward resource allocation priorities for BC prevention, screening, and treatment that could potentially decrease productivity losses. Careful consideration should be given to BC-specific policies, such as surveillance programs and the availability of new treatments in CEE countries to decrease the medical and financial burden of the disease.
A time dependent approach to model X-ray and $γ$--ray light curves of Mrk 421 observed during the flare in February 2010
Creators: name: Singh, K K
name: Sahayanathan, S
name: Sinha, A
name: Bhatt, N
name: Tickoo, A K
name: Yadav, K K
name: Rannot, R C
name: Chandra, P
name: Venugopal, K
name: Marandi, P
name: Kumar, N
name: Goyal, H C
name: Goyal, A
name: Agarwal, N K
name: Kothari, M
name: Chanchalani, K
name: Dhar, V K
name: Chouhan, N
name: Bhat, C K
name: Koul, M K
name: Koul, R
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Strong X-ray and $γ$--ray flares have been detected in February 2010 from the high synchrotron peaked blazar Mrk 421 (z=0.031). With the motivation of understanding the physics involved in this flaring activity, we study the variability of the source in X-ray and $γ$--ray energy bands during the period February 10-23, 2010 (MJD 55237-55250). We use near simultaneous X-ray data collected by \emph{MAXI}, \emph{Swift}-XRT and $γ$--ray data collected by \emph{Fermi}-LAT and \emph{TACTIC} along with the optical V-band observations by \emph{SPOL} at Steward Observatory. We observe that the variation in the one day averaged flux from the source during the flare is characterized by fast rise and slow decay. Besides, the TeV $γ$--ray flux shows a strong correlation with the X-ray flux, suggesting the former to be an outcome of synchrotron self Compton emission process. To model the observed X-ray and $γ$--ray light curves, we numerically solve the kinetic equation describing the evolution of particle distribution in the emission region. The injection of particle distribution into the emission region, from the putative acceleration region, is assumed to be a time dependent power law. The synchrotron and synchrotron self Compton emission from the evolving particle distribution in the emission region are used to reproduce the X-ray and $γ$--ray flares successfully. Our study suggests that the flaring activity of Mrk 421 can be an outcome of an efficient acceleration process associated with the increase in underlying non-thermal particle distribution.
description: Accepted for publication in New Astronomy
Bayesian Finite Mixture Models
Creators: name: Grün, Bettina
name: Malsiner-Walli, Gertraud
Publisher: name: arXiv
Year: 2024
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Finite mixture models are a useful statistical model class for clustering and density approximation. In the Bayesian framework finite mixture models require the specification of suitable priors in addition to the data model. These priors allow to avoid spurious results and provide a principled way to define cluster shapes and a preference for specific cluster solutions. A generic model estimation scheme for finite mixtures with a fixed number of components is available using Markov chain Monte Carlo (MCMC) sampling with data augmentation. The posterior allows to assess uncertainty in a comprehensive way, but component-specific posterior inference requires resolving the label switching issue.
 In this paper we focus on the application of Bayesian finite mixture models for clustering. We start with discussing suitable specification, estimation and inference of the model if the number of components is assumed to be known. We then continue to explain suitable strategies for fitting Bayesian finite mixture models when the number of components is not known. In addition, all steps required to perform Bayesian finite mixture modeling are illustrated on a data example where a finite mixture model of multivariate Gaussian distributions is fitted. Suitable prior specification, estimation using MCMC and posterior inference are discussed for this example assuming the number of components to be known as well as unknown.
title: Instrument de recherche du fonds Michel Vovelle à la Médiathèque de la MMSH
Creators: name: Gill, Tatyana
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: catalogue
subject: Archives publiques
subject: archives de la recherche
subject: histoire culturelle
subject: Provence
subject: Michel Vovelle

description: Catalogue du fonds Michel Vovelle versé au secteur Archives de la recherche de la Médiathèque de la Maison méditerranéenne des sciences de l'homme
description: Catalogue du fonds d'archives Michel Vovelle au format PDF
Supplementary Materials from Evaluating pro-arrhythmogenic effects of the T634S-hERG mutation: insights from a simulation study
Creators: name: Hu, Wei
name: Zhang, Wenfeng
name: Zhang, Kevin
name: Al-Moubarak, Ehab
name: Zhang, Yihong
name: Harmer, Stephen C.
name: Hancox, Jules C.
name: Zhang, Henggui
Publisher: name: The Royal Society
Year: 2023
Subjects: classificationCode: 310114
subject: Systems biology
classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified
classificationCode: 490102
subject: Biological mathematics

description: Details of methods and supporting results
Clinical benefits and economic cost-savings of Remote Electrical Neuromodulation (REN) for migraine prevention
Creators: name: Cowan, R
name: Stark-Inbar, A
name: Rabany, L
name: Harris, D
name: Vizel, M
name: Ironi, A
name: Vieira, JR
name: Galen, M
name: Treppendahl, C
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Assess the clinical benefits and associated direct and indirect cost-savings from Remote Electrical Neuromodulation (REN) for migraine prevention. REN, a prescribed, wearable, FDA-cleared neuromodulation-device for the acute and/or treatment of migraine, recently demonstrated efficacy for migraine prevention when used every-other-day, in a prospective, randomized, double-blind, placebo-controlled, multi-center study. Following baseline (4-weeks), subjects underwent treatment with REN (or placebo; 8-weeks), and electronically reported migraine symptoms and acute treatments daily. Therapeutic-gain was the between-groups difference (REN minus placebo) in change from baseline to the second month of intervention. Health-economics impact was derived as cost-savings associated with REN’s clinical benefits. Out of 248 subjects randomized (128 active, 120 placebo), 179 (95:84) qualified for modifiedintention-to-treat (mITT) analysis. Significant therapeutic gains favoring REN vs placebo were found (Tepper et al., 2023), including mean (±SD) reduction in number of acute medication days (3.4 ± 0.4 vs 1.2 ± 0.5; gain = 2.2; p = 0.001) and presenteeism days (2.7 ± 0.3 vs 1.1 ± 0.4; p = 0.001). Mean changes of provider visits (reduction of 0.09 ± 0.1 vs increase of 0.08 ± 0.2; p = 0.297), and reduction of absenteeism days (0.07 ± 0.1 vs 0.07 ± 0.2; p = 0.997) were not significant. Mean annual cost-saving for one patient using REN for migraine prevention estimated $10,000 (±$1,777) from reductions in these four clinical outcomes relative to baseline without REN treatment. Extrapolated to a hypothetical US commercial health-plan of one-million covered lives, assuming the national prevalence of migraine patients on preventive treatment, annual mean (±SE) cost-saving from using REN migraine prevention estimated $560.0 million (±$99.5 million) from reduction in direct and indirect metrics measured. Clinical and cost-savings benefits presented are conservative, assessed only from endpoints measured in the clinical trial. Moreover, some of the endpoints had only scarce or no occurrences during the study period. Demonstrated significant and meaningful clinical, and cost-savings benefits for patients, health insurance systems, and employers, from utilizing REN for migraine prevention.
Collective legal autonomy concerning traditional ecological knowledge: the rights of indigenous peoples and their linkages to biodiversity conservation in Colombia and Australia
Creators: name: Rodríguez-Uribe, Natalia
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis compares the legal status of biodiversity conservation and the recognition of the human rights of Indigenous peoples in Australia and Colombia. It argues that these two areas are legally protected interests that often collide. One interest cannot be sacrificed for the sake of the other and thus a Pareto optimal balance has to be reached. The aim of the research is to ascertain the most suitable model to achieve biodiversity conservation objectives in territories inhabited or otherwise used by Indigenous peoples. For accomplishing this aim, the thesis critically assesses the models of fortress conservation and community-based conservation (CBC), grounded in the discipline of international environmental law. It argues that the first model, based on the premise of keeping people separate to pristine wildernesses, evolved towards the more inclusive second model, which is currently considered best practice. Australia currently implements CBC and has co-management agreements with Aboriginal and Torres Strait Islander peoples for protected areas. The thesis challenges both of these models on the basis that they do not optimise both interests, and proposes a third human rights–based model, called the collective legal autonomy concerning traditional ecological knowledge (TEK). The collective legal autonomy concerning TEK is grounded in differentiated collective human rights entitled to Indigenous communities in their quality as peoples. By analysing the Colombian Constitution and the rulings of the Constitutional Court, along with case studies of Indigenous communities in the country, the thesis concludes that this human rights–based model achieves a Pareto optimal solution between the two legally protected interests of biodiversity conservation and the recognition of the rights of Indigenous peoples.
Cost-effectiveness of combination therapy of polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisolone for previously untreated diffuse large B-cell lymphoma in Japan
Creators: name: Mizuoka, Takashi
name: Sakamaki, Hiroyuki
name: Fuji, Shigeo
name: Saito, Shota
name: Murata, Tatsunori
name: Ohno, Shinya
name: Inubashiri, Naoki
name: Oshima, Tomoha
name: Yamamoto, Kazuhito
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: The POLARIX trial showed that Pola + R-CHP (polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisolone) prolongs progression-free survival (PFS) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL) compared with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone), the conventional standard of care, with a similar safety profile. However, Pola + R-CHP has not been evaluated from the viewpoint of health economics in Japan. This study evaluates the cost-effectiveness of Pola + R-CHP for previously untreated DLBCL from a Japanese public healthcare payer’s perspective. A partitioned survival analysis model was constructed to estimate lifetime costs and effectiveness of Pola + R-CHP and R-CHOP in previously untreated DLBCL who had an International Prognostic Index score (IPI) score of ≥2. A parametric survival model was applied to data analyzed in the POLARIX trial to estimate the lifetime overall survival (OS) and PFS for each treatment. The parameters required for the model were based on the results of a literature search and expert opinion. The incremental cost-effectiveness ratio (ICER) of Pola + R-CHP vs. R-CHOP was JPY2,710,238 per quality-adjusted life year (QALY), less than the ICER of JPY7.5 million per QALY that is considered to be cost-effective based on the threshold of the Japanese cost-effectiveness evaluation system. One-way sensitivity analysis showed that the parameters influencing the results of the analysis were median PFS and the total cost per regimen of salvage chemotherapy, patient weight, and patient age. Probabilistic sensitivity analysis showed that the probability of Pola + R-CHP having superior cost-effectiveness was 99.2% when the reference value was JPY7.5 million. The results of scenario analysis suggested that prolongation of PFS was an important factor in the evaluation of cost-effectiveness in previously untreated DLBCL with or without prolongation of OS. This study suggests that Pola + R-CHP is a cost-effective treatment for previously untreated DLBCL in Japan under the public health insurance system.
Additional file 1: of Structure formats of randomised controlled trial abstracts: a cross-sectional analysis of their current usage and association with methodology reporting
Creators: name: Hua, Fang
name: Walsh, Tanya
name: Glenny, Anne-Marie
name: Worthington, Helen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Study Protocol. (DOCX 52 kb)
Reverse isolation and backaction of the SLUG microwave amplifier
Creators: name: Thorbeck, T.
name: Zhu, S.
name: Leonard, E.
name: Barends, R.
name: Kelly, J.
name: Martinis, John M.
name: McDermott, R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: An ideal preamplifier for qubit measurement must not only provide high gain and near quantum-limited noise performance, but also isolate the delicate quantum circuit from noisy downstream measurement stages while producing negligible backaction. Here we use a Superconducting Low-inductance Undulatory Galvanometer (SLUG) microwave amplifier to read out a superconducting transmon qubit, and we characterize both reverse isolation and measurement backaction of the SLUG. For appropriate dc bias, the SLUG achieves reverse isolation that is better than that of a commercial cryogenic isolator. Moreover, SLUG backaction is dominated by thermal emission from dissipative elements in the device. When the SLUG is operated in pulsed mode, it is possible to characterize the transmon qubit using a measurement chain that is free from cryogenic isolators or circulators with no measurable degradation of qubit performance.
description: 5 pages, 4 figures
Realizing and manipulating space-time inversion symmetric topological semimetal bands with superconducting quantum circuits
Creators: name: Tan, Xinsheng
name: Zhao, Yuxin
name: Liu, Qiang
name: Xue, Guangming
name: Yu, Haifeng
name: Wang, Zidan
name: Yu, Yang
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have experimentally realized novel space-time inversion (P-T) invariant Z2-type topological semimetal-bands, via an analogy between the momentum space and a controllable parameter space in superconducting quantum circuits. By measuring the whole energy spectrum of system, we imaged clearly an exotic tunable gapless band structure of topological semimetals. Two topological quantum phase transitions from a topological semimetal to two kinds of insulators can be manipulated by continuously tuning the different parameters in the experimental setup, one of which captures the Z2 topology of the PT semimetal via merging a pair of nontrivial Z2 Dirac points. Remarkably, the topological robustness was demonstrated unambiguously, by adding a perturbation that breaks only the individual T and P symmetries but keeps the joint PT symmetry. In contrast, when another kind of PT -violated perturbation is introduced, a topologically trivial insulator gap is fully opened.
MOESM2 of Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes
Creators: name: Li, Xuemei
name: Yang, Jinyu
name: Pu, Qian
name: Peng, Xinyue
name: Xu, Lili
name: Liu, Shiping
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 2: Figure S1. Different doses of dsSHMT exerted different effect on the flight ability and oviposition of mosquitoes. Different doses of dsSHMT (50, 100, 200, 400 and 800 ng) dissolved in 0.5 μl of nuclease-free water were separately injected into mosquitoes at 16 h PE (see “Methods”). The phenotype of mosquitoes was examined at five time points post-blood-meal (PBM), namely 15, 17, 19, 24, 30 and 40 h PBM. a Effect on flight ability of mosquitoes. b Effect on the oviposition of mosquitoes. Figure S2. Transcriptional expression of trypsins responding to SHMT RNAi. The data are shown as the mean ± SEM. *P < 0.05; **P < 0.01; ns, not significant. Figure S3. Transcriptional expression of chymotrypsins responding to SHMT RNAi. All graphs have the same abscissa, i.e. three samples, WT, dsEGFP and dsSHMT. The data are shown as mean ± SEM. *P < 0.05; **P < 0.01; ns, not significant. Figure S4. Transcriptional expression of carboxypeptidases and serine proteases responding to SHMT RNAi. a Transcriptional expression of carboxypeptidases. b Transcriptional expression of serine protease. The data are shown as the mean ± SEM. *P < 0.05.
Beyond the citation: Using Figshare and Altmetric to publish, promote, track, and analyze academic outputs across disciplines
Creators: name: Engineering, Altmetric
Publisher: name: Altmetric
Year: 2024
Subjects: classificationCode: 461099
subject: Library and information studies not elsewhere classified

description: Academic outputs are more than papers and datasets.
Art performances, conceptual designs, music scores, costumes, models, and all other non-traditional research outputs can be shared, showcased, and tracked.
In this presentation we will explore:How to share and showcase non-traditional research outputs in FigshareHow DOIs and robust metadata can ensure these outputs are discoverable and citableHow Altmetric attention data provides unique insight into the online conversations surrounding these outputs

Sharing real examples from institutions around the world, product specialists from both Figshare and Altmetric will provide an overview of how you can share academic outputs from all disciplines and begin assessing impact.
The epidemiology and healthcare costs of community-acquired pneumonia in Ontario, Canada: a population-based cohort study
Creators: name: O’Reilly, Ryan
name: Lu, Hong
name: Kwong, Jeffrey C.
name: McGeer, Allison
name: To, Teresa
name: Sander, Beate
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy
Computational Biology

description: The aim of the present study was to determine incidence-based short- and long-term healthcare costs attributable to community-acquired pneumonia (CAP) from the healthcare payer perspective in Ontario, Canada. We conducted a retrospective population-based matched cohort study of residents in Ontario, Canada using health administrative data. We identified subjects with an incident episode of CAP (exposed subjects) between 1 January 2012 and 31 December 2014. The index date of each episode was based on the first inpatient or outpatient claim for pneumonia. Exposed subjects were matched without replacement to unexposed subjects from the general population using hard and propensity score matching on age, sex, income quintile, rural residence, comorbidities, and healthcare costs prior to index date. Attributable costs represented the mean difference in costs between the exposed subjects and their matched pairs. We identified 692,090 subjects with at least one episode of CAP between 1 January 2012 and 31 December 2014. Adults aged 65 years and older had the highest annual incidence rate of 50.1 episodes per 1,000 person-years, while adults aged 18–64 years and children (aged 0–17) had incidence rates of 12.9 and 24.7 episodes per 1,000 person-years, respectively. The majority of episodes involved care exclusively in the outpatient setting (92.6%), with most of these episodes involving a single physician visit. The mean attributable costs were $1,595 (95% CI: $1,572–$1,616) per outpatient CAP episode and $12,576 (95% CI: $12.392–$12,761) per inpatient CAP episode. Attributable costs were significantly higher for adult subjects and those with time spent in the intensive care unit. Alternative case definitions yielded different results, although demonstrated the same overall trends across groups. CAP is associated with substantially increased acute and long-term healthcare costs compared to unexposed subjects. This study highlights the burden of CAP in both the inpatient and outpatient setting, and will serve to inform strategic healthcare planning for future interventions and healthcare programs.
Additional file 3: of The function of tcf3 in medaka embryos: efficient knockdown with pePNAs
Creators: name: Doenz, Gerlinde
name: Dorn, Sebastian
name: Aghaallaei, Narges
name: Baubak Bajoghli
name: Riegel, Elisabeth
name: Aigner, Michaela
name: Bock, Holger
name: Werner, Birgit
name: Lindhorst, Thomas
name: Czerny, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Mammalian two-hybrid analysis of Aes-mediated Gro/Tle repression. 20 ng of the expression constructs (pMCamVP16, pMCTle4VP16 or pMCTle1VP16) were co-transfected with 70 ng of firefly luciferase reporter construct pLucF24ZF, 20 ng of the expression construct for the six-domain of human Six3 (pMChSix3(85-203)mZFb6) and full length Aes (pKCAes at the indicated concentrations) into HeLa cells. The interaction of the artificial leucine zipper domain “acid” and “base” [63] was used as a control. All three interactions were set 100% in the absence of Aes (acid/base corresponds to a more than 100 fold activation of the luc reporter construct compared to a control without bait, similar induction rates were seen for Tle4/Six3 and Tle1/Six3). Addition of the Aes expression construct at the indicated concentrations did not affect the acid/base interaction (blue bars), but strongly reduced the Tle4/Six3- (red bars) and the Tle1/Six3 interaction (green bars). (PDF 10028 kb)