cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A perspective of lipid nanoparticles for RNA delivery
Creators: name: Lin, Xin
name: Ma, Yutian
name: Chen, Yupeng
name: Li, Shiyao
Publisher: name: Wiley
Year: 2024

description:
Over the last two decades, lipid nanoparticles (LNPs) have evolved as an effective biocompatible and biodegradable RNA delivery platform in the fields of nanomedicine, biotechnology, and drug delivery. They are novel bionanomaterials that can be used to encapsulate a wide range of biomolecules, such as mRNA, as demonstrated by the current successes of COVID‐19 mRNA vaccines. Therefore, it is important to provide a perspective on LNPs for RNA delivery, which further offers useful guidance for researchers who want to work in the RNA‐based LNP field. This perspective first summarizes the approaches for the preparation of LNPs, followed by the introduction of the key characterization parameters. Then, the in vitro cell experiments to study LNP performance, including cell selection, cell viability, cellular association/uptake, endosomal escape, and their efficacy, were summarized. Finally, the in vivo animal experiments in the aspects of animal selection, administration, dosing and safety, and their therapeutic efficacy were discussed. The authors hope this perspective can offer valuable guidance to researchers who enter the field of RNA‐based LNPs and help them understand the crucial parameters that RNA‐based LNPs demand.
Linear DNA-driven recombination in mammalian mitochondria
Creators: name: Hangas, Anu
name: Fragkoulis, Georgios
name: Michell, Craig
name: Pohjoismäki, Jaakko L O
name: Fekete, Zsófia
name: Moraes, Carlos T
name: Griffith, Jack D
name: Willcox, Smaranda
name: Goffart, Steffi
Publisher: name: Oxford University Press (OUP)
Year: 2024

description:
Mitochondrial DNA (mtDNA) recombination in animals has remained enigmatic due to its uniparental inheritance and subsequent homoplasmic state, which excludes the biological need for genetic recombination, as well as limits tools to study it. However, molecular recombination is an important genome maintenance mechanism for all organisms, most notably being required for double-strand break repair. To demonstrate the existence of mtDNA recombination, we took advantage of a cell model with two different types of mitochondrial genomes and impaired its ability to degrade broken mtDNA. The resulting excess of linear DNA fragments caused increased formation of cruciform mtDNA, appearance of heterodimeric mtDNA complexes and recombinant mtDNA genomes, detectable by Southern blot and by long range PacBio® HiFi sequencing approach. Besides utilizing different electrophoretic methods, we also directly observed molecular complexes between different mtDNA haplotypes and recombination intermediates using transmission electron microscopy. We propose that the known copy-choice recombination by mitochondrial replisome could be sufficient for the needs of the small genome, thus removing the requirement for a specialized mitochondrial recombinase. The error-proneness of this system is likely to contribute to the formation of pathological mtDNA rearrangements.
Dr. Fr. Falk, Die pfarramtlichen Aufzeichnungen des Florentius Diel zu St. Christoph in Mainz
Creators: name: Ehses, Stephan
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 20 Nr. 2 (1906): Römische Quartalschrift, Band 20, Heft 2
Additional file 6 of The combination of PD-L1 expression and the neutrophil-to-lymphocyte ratio as a prognostic factor of postoperative recurrence in non-small-cell lung cancer: a retrospective cohort study
Creators: name: Samejima, Hironobu
name: Kojima, Kensuke
name: Fujiwara, Ayako
name: Tokunaga, Toshiteru
name: Okishio, Kyoichi
name: Yoon, Hyungeun
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 6: Supplemental Table S2. Results of a Cox proportional hazard analysis of RFS according to the product of PD-L1 and the NLR as a continuous variable.
Wo steht die App für Nutzschweine nach dem ersten Jahr?
Creators: name: Egle, Claudia
name: Ritley, Kenneth
Publisher: name: Berner Fachhochschule, Wirtschaft
Year: 2024

description: Das Pig Health Info System (PHIS) ist vor einem Jahr gestartet und überwacht die Gesundheit der Schweizer Nutzschweine. 40 Tierarztpraxen haben die App inzwischen genutzt und mehr als 2’000 Berichte erfasst. Über die Roll-out-Phase und die Praxiserfahrungen ziehen die Forschenden hier Bilanz.
The impact of fentanyl on state- and county-level psychostimulant and cocaine overdose death rates by race in Ohio from 2010 to 2020: a time series and spatiotemporal analysis
Creators: name: White, Brian N.
name: Miller, William C.
name: Estadt, Angela T.
name: Kline, David
name: Lancaster, Kathryn E.
name: Ricks, JaNelle M.
name: Hepler, Staci
Publisher: name: Springer Nature
Year: 2024

description:
Background Over the past decade in the USA, increases in overdose rates of cocaine and psychostimulants with opioids were highest among Black, compared to White, populations. Whether fentanyl has contributed to the rise in cocaine and psychostimulant overdoses in Ohio is unknown. We sought to measure the impact of fentanyl on cocaine and psychostimulant overdose death rates by race in Ohio.


Methods We conducted time series and spatiotemporal analyses using data from the Ohio Public Health Information Warehouse. Primary outcomes were state- and county-level overdose death rates from 2010 to 2020 for Black and White populations. Measures of interest were overdoses consisting of four drug involvement classes: (1) all cocaine overdoses, (2) cocaine overdoses not involving fentanyl, (3) all psychostimulant overdoses, and (4) psychostimulant overdoses not involving fentanyl. We fit a time series model of log standardized mortality ratios (SMRs) using a Bayesian generalized linear mixed model to estimate posterior median rate ratios (RR). We conducted a spatiotemporal analysis by modeling the SMR for each drug class at the county level to characterize county-level variation over time.


Results In 2020, the greatest overdose rates involved cocaine among Black (24.8 deaths/100,000 people) and psychostimulants among White (10.1 deaths/100,000 people) populations. Annual mortality rate ratios were highest for psychostimulant-involved overdoses among Black (aRR = 1.71; 95% CI (1.43, 2.02)) and White (aRR = 1.60, 95% CI (1.39, 1.80)) populations. For cocaine not involving fentanyl, annual mortality rate ratios were similar among Black (aRR = 1.04; 95% CI (0.96,1.16)) and White (aRR = 1.02; 95% CI (0.87, 1.20)) populations. Within each drug category, change over time was similar for both racial groups. The spatial models highlighted county-level variation for all drug categories.


Conclusions Without the involvement of fentanyl, cocaine overdoses remained constant while psychostimulant overdoses increased. Tailored harm reduction approaches, such as distribution of fentanyl test strips and the removal of punitive laws that influence decisions to contact emergency services, are the first steps to reduce cocaine overdose rates involving fentanyl among urban populations in Ohio. In parallel, harm reduction policies to address the increase in psychostimulant overdoses are warranted.
title: Unravelling Malaysian Subjectivity: Political Identification and Bodily Experience in New Media Art
Creators: name: Sitharan, Roopesh
Publisher: name: Goldsmiths, University of London
Year: 2018
Subjects: subject: Malaysian studies, subjectivity, racial identity, nationality, new media art, art practice, Malaysian art history and theory, cultural studies

description: In this thesis, I attempt to unravel the Malaysian subjectivity with regards to the racialized body, as well as in relation to the new media art practice. A Malaysian subject is formally identified with racial identity in order to distinguish between the Malay and rest of the citizens. It is an identification that aims to classify the Malaysian population into racial groups, but never manages to represent the subject in its totality. Due to this, every Malaysian is burdened with a racialization of body that informs their individual lived experience. This research attempts to probe into this lived experience. It argues that this discrepancy between the lived experience and racial marking leads to an epistemological uncertainty that informs the Malaysian subjectivity. Adapting the work of Deleuze and Guattari on machinic assemblage, as well as Bernard Stiegler’s idea on ‘Technics and Time’ the current thesis tries to discover what it means to be a Malaysian – to think beyond the mere racial body. By treating the body as an assemblage process, necessarily employing influences from external forces in order to come into being, I examine how contemporary Malaysian new media art practice is entangled with the production of Malaysian subjectivity. The research is located within my own subjective approach as a key ingredient for the unravelling of Malaysian subjectivity. It is my contention that such an enquiry on the subjectivity, effectively, cannot develop as long as it tries to emulate a positivist and objectivist model of research. I assert that only through critical reflection gained by my new media art practice can I account for an epistemological uncertainty central to the experience of bearing the racial identity as a Malaysian.
Regional variation in forest landscape restoration
Creators: name: Sabogal, Cesar
name: Blaser, Jürgen
name: Shono, Kenichi
name: Tegegne, Yitagesu Tekle
name: Zamora-Cristales, Rene
name: Sitoe, Almeida
name: Ammour, Tania
name: Dontenville, Adeline
name: Feurer, Mélanie
name: Markovic, Jelena
name: Besacier, Christophe
name: Simonit, Silvio
name: De Ridder, Benjamin
name: Jonsson, Orjan
Publisher: name: Oxford University Press
Year: 2024

description: This chapter explores how restoration is proposed and implemented across selected world regions and how various contextual conditions influence these processes. Gaining a better understanding of the regional/country differences provides important insights for planning and implementing national/subnational forest landscape restoration (FLR) agendas. Eight regions are compared using a set of mostly qualitative variables: Central America & Mexico, Tropical South America, West Africa, East Africa, Southeast Asia, South Asia, Central Asia, and Eastern & South-Eastern Europe. The comparison considers the implementation contexts (forest resources, drivers of land cover change, and rationales) and the implementation tools (policy, institutional, social, economic, and technical interventions undertaken at the country/regional levels) for FLR. The regional comparison includes an in-depth review of the FLR process in a suite of countries for each region. The chapter concludes with a comparison of the regional variation in FLR implementation, highlighting common challenges.
Qualitätsreserven besser ausschöpfen: Ergebnisse des Projekts QuVert
Creators: name: Schori, Stefan
name: Höckel, Michael
name: Buntschu, Ron Bruno
Publisher: name: Electrosuisse
Year: 2024

description: Um das Verteilnetz effizient zu planen und zu nutzen, ist es wichtig, die Quali­täts­reserven zu kennen und alternative Massnahmen zur Netzverstärkung gezielt einzusetzen. Im Projekt QuVert wurden die Quali­täts­reserven analysiert, Massnahmen verglichen und ein generisches Überwachungskonzept formuliert.
Additional file 2 of Neuromolecular responses in disrupted mutualistic cleaning interactions under future environmental conditions
Creators: name: Ramírez-Calero, S.
name: Paula, J. R.
name: Otjacques, E.
name: Ravasi, T.
name: Rosa, R.
name: Schunter, C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 2: Figure S1. Unique and overlapping differentially expressed genes (DEGs) present in the warming condition for L. dimidiatus. Figure S2. Unique and overlapping differentially expressed genes (DEGs) present in the high CO2 condition for L. dimidiatus. Figure S3. Unique and overlapping differentially expressed genes (DEGs) present in the warming& high CO2 condition for L. dimidiatus. Figure S4. Unique and overlapping differentially expressed genes (DEGs) present in the warming condition for A. leucosternon. Figure S5. Unique and overlapping differentially expressed genes (DEGs) present in the high CO2 condition for A. leucosternon. Figure S6. Unique and overlapping differentially expressed genes (DEGs) present in warming & high CO2 condition for A. leucosternon. Figure S7.PCA’s of normalized gene counts using the design ~brain_region + treatment and a rlog transformation (rld) for each environmental treatment: a) warming, b) high CO2 and c) warming & high CO2) for A. leucosternon. Figure S8. PCA’s of normalized gene counts using the design ~brain_region + treatment and a rlog transformation (rld) for each environmental treatment: a) warming, b) high CO2 and c) warming & high CO2 for L, dimidiatus.
Simulation-Based Stress Tests: Integrated Simulation Approach for Assessing Resilience of Transport Systems under Multiple Stressors
Creators: name: Nasrazadani, Hossein
name: Adey, Bryan T.
name: Dorren, Luuk
Publisher: name: American Society of Civil Engineers (ASCE)
Year: 2024

description: A transportation system stress test is a set of one or more hypothetical scenarios designed to help determine if a transport system can continue to provide an acceptable level of service when subjected to one or more potentially disruptive events. Stress tests, if done well, enable policy makers, regulators, and network operators to assess the ability of transport systems to withstand and recover from potentially disruptive events, and modify the systems if necessary. Although work has been conducted on how to conduct high-level preliminary transportation stress tests, there has not yet been work conducted on how to conduct detailed quantitative simulation-based stress tests on transportation systems. This paper fills this gap by presenting both an approach to conduct simulation-based stress tests and example simulation-based stress tests for a transportation system subject to potentially disruptive hydrometeorological events. Three types of stress tests are conducted for the transportation system in the region of Chur, Switzerland, which is subject to heavy rainfalls that may result in floods and landslides. These include the stress caused by climate change leading to increasing the intensity of extreme rainfall events in the future, stress caused by uncertain future mobility behavior of people leading to excessive travel demand on the network, and stress caused by poor planning of the required resources for restoration interventions leading to having less resources for restoration than planned. It is argued that conducting such stress tests makes it clear to decision makers whether or not a transportation system is sufficiently resilient against various stressors, and if not, gives clear indications as to how it could be improved.
Supplementary Material from Genome assembly of the southern pine beetle (Dendroctonus frontalis Zimmerman) reveal the origins of gene content reduction in Dendroctonus
Creators: name: Copeland, Megan
name: Landa, Shelby
name: Owoyemi, Adekola Oluwatosin
name: Jonika, Michelle M
name: Alfieri, James M
name: Johnston, J. Spencer
name: Sylvester, Terrence Pradakshana
name: Kyre, Bethany R
name: Hoover, Zachary
name: Hjelmen, Carl E
name: Lynne, Rieske K
name: Blackmon, Heath
name: Casola, Claudio
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified

description: SPB-supporting figures RSOS_revised.docx
title: Mournings and Uncertainties
Creators: name: Kim, Kyoung
Publisher: name: Goldsmiths, University of London
Year: 2018
Subjects: subject: mourning, moaning, political disappearance, aesthetics, perception, alterity, difference, Fred Moten, black mo’nin’, ocularcentrism, Emmett Till, lynching, postmortem photography, memento mori

description: This project makes available a language by which mourning can be expressed and explored as an epistemic concern and as an urgent matter to rethink politics in relation to difference. Through a situated, multidirectional investigation of its sensory, political, aesthetic, and psychoanalytic distributions, I claim that mourning—as the perceiving of alterity in relation to perceived ‘loss’—produces a political subject exposed to uncertainty and the possibilities of community and ‘moaning’. I propose ‘moaning’ as a mode of perceptual uncertain knowledge production. Engaging with Fred Moten’s (2003) conceptualisation of ‘black mo’nin’’ in relation to postmortem photographs of Emmett Till, a black teenager who was lynched in 1955, I examine the socio-political stakes of moaning. Following Moten’s attention to aesthetics as a political and epistemic concern, I formulate two modes of aesthetic perception: ‘moaning aesthetics’ as uncertain re-distributing perceiving of sights and sounds open to new political possibilities; and ‘hegemonic aesthetics’ as a closed, self-affirming cycle between hearing and seeing that disappears politics. I then ask: How, under conditions of political disappearance, might politics be regained by way of perception? Through re/analyses of and re/encounterings with the postmortem photographs of Emmett Till in relation to ‘lynching photographs’ of Elias Clayton, Elmer Jackson, Isaac McGhie, Lige Daniels, William Brown, Laura Nelson, Will James, Richard Dillon, August Goodman, Jesse Washington, Thomas Shipp, Abram Smith, George Meadows, Garfield Burley, Curtis Brown, Lee Hall, Bennie Simmons, Will Moore, Clyde Johnson, Leonard Woods, John Richards, Rubin Stacy, W.C. or R.C. Williams, and four unidentified persons, and ‘memento mori photographs’ from James Van Der Zee’s The Harlem Book of the Dead (1978) and the Thanatos Archive, I advance that moaning is critical for ‘dis-appearing’—as in appearing new political subjectivities and possibilities from a condition of having been disappeared—and that perceiving political unknown, uncertain possibilities is politically vital.
Ignaz Philipp Dengel, Die politische und kirchliche Tätigkeit des Msgr. Josef Garampi in Deutschland
Creators: name: Ehses, Stephan
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 20 Nr. 2 (1906): Römische Quartalschrift, Band 20, Heft 2
title: Learning After ‘New Institutionalism’: Democracy and Tate Modern Public Programme
Creators: name: Hodby, Alexandra Jane
Publisher: name: Goldsmiths, University of London
Year: 2018
Subjects: subject: Tate Modern, museums, galleries, learning, democracy

description: This thesis examines the failure of the curatorial discourse of ‘New Institutionalism’ in relation to the Public Programme at Tate Modern. It argues that New Institutionalism, despite being unable to describe the complexity of art organisations, nevertheless recognised the importance of the latter as an active part of democracy. In the course of its investigation, the thesis establishes a unique history of Public Programming at Tate Modern and shows how learning activities in Tate Modern continued to deploy the values of New Institutionalism (in particular, those of dialogue and participation) long after its failure and decline.

By developing an understanding of Tate Modern's Public Programme beyond the oppositional politics of New Institutionalism, the thesis seeks also to develop a more complex analysis of democracy in relation to art museum politics. In so doing, it explores practices of power and authority in the art museum and considers the importance of the museum in relation to democratic citizenship and community, arguing that an art museum is the agent of a more complex learning about the nature and politicisation of ‘the democratic’. Similarly, by drawing attention to the public spaces of the art museum, and by engaging with urgent issues of openness and publicness, the thesis investigates the site-specificity of museum practices after New Institutionalism. Finally, the thesis argues that Tate Modern Public Programming performs a role in democratic society that moves beyond learning about art and towards a reimagining of democracy itself. Activities in an art museum, it claims, are not models for democratic society, but rather, they represent democracy in action, evidencing a complex and potent site where issues including politics, community, control and creativity are at stake.
Happy Little Vegemites™! An analysis of the contribution of yeast extract spreads and tomato‐based sauces to nutrient intake adequacy in Australia
Creators: name: Whatnall, Megan
name: Clarke, Erin D.
name: Bucher, Tamara
name: Collins, Clare E.
Publisher: name: Wiley
Year: 2024
Subjects: Australian Health Survey
Condiments
Dietary intake
Nutriment intake
Tomato sauce
Yeast extract spread

description: Background: Yeast extract spreads and tomato‐based sauces (i.e., ketchup) are consumed regularly by the Australian population. Therefore, there is a need to explore the contribution of these condiments to nutrient intakes among Australians. Methods: The present study comprises a secondary analysis of data from the 2011–2012 Australian National Nutrition and Physical Activity Survey. Dietary intake data were undertaken for 12,153 Australians aged ≥ 2 years, using 24‐h recalls. Yeast extract spreads and tomato‐based sauces were categorised based on how they were defined in the Australian Food and Nutrient (AUSNUT) 2011–2013 database. Kruskal–Wallis H tests and the post‐hoc Dunn's test with Bonferroni correction were applied to test whether a significant difference existed in the percentage contribution of yeast extract spreads and tomato‐based sauces to intakes of select nutrients. Results: In total, 19.6% (n = 2384) of the population sample consumed yeast extract spreads and/or tomato‐based sauces during the 24‐h recall. The percentage contribution of yeast extract spreads to daily intakes of sodium, potassium, thiamine, riboflavin, niacin, folate, magnesium, iron, zinc and iodine were significantly higher in line with a greater quantity of yeast extract spread consumed (p < 0.05). The percentage contribution of tomato‐based sauces to daily intakes of sodium, potassium, riboflavin, niacin, folate, beta‐carotene, magnesium, iron, zinc and iodine was increased significantly with a greater quantity of tomato‐based sauces consumed (p < 0.05). Conclusions: Consumption of yeast extracts and tomato‐based sauces contribute to greater intake of key nutrients, such as B‐vitamins and beta‐ carotene, and may assist in meeting key nutrient reference values. However, consumption of these sauces and condiments also resulted in greater intakes of sodium, contributing to population intakes exceeding recommendations. Reducing sodium content of frequently consumed condiments may potentially assist in lowering population intakes, at the same time as preserving intakes of other important nutrients.
Chloroquine has shown high therapeutic efficacy against uncomplicated Plasmodium vivax malaria in southern Ethiopia: seven decades after its introduction
Creators: name: Haile, Mebrahtom
name: Gidey, Bekuretsion
name: Abay, Solomon Mequanente
name: Parr, Jonathan B.
name: Gubae, Kale
name: Tasew, Geremew
name: Assefa, Ashenafi
name: Bekele, Worku
name: Price, Rick
name: Hailgiorgis, Henok
name: Mohammed, Hussein
name: Assefa, Gudissa
name: Auburn, Sarah
name: Sime, Heven
name: Mare, Anteneh Kassahun
name: Juliano, Jonathan J.
Publisher: name: Springer Nature
Year: 2024

description:
Background Plasmodium vivax malaria is a leading cause of morbidity in Ethiopia. The first-line treatment for P. vivax is chloroquine (CQ) and primaquine (PQ), but there have been local reports of CQ resistance. A clinical study was conducted to determine the efficacy of CQ for the treatment of P. vivax malaria in southern Ethiopia.


Methods In 2021, patients with P. vivax mono-infection and uncomplicated malaria were enrolled and treated with 25 mg/kg CQ for 3 consecutive days. Patients were followed for 28 days according to WHO guidelines. The data were analysed using per-protocol (PP) and Kaplan‒Meier (K‒M) analyses to estimate the risk of recurrent P. vivax parasitaemia on day 28.


Results A total of 88 patients were enrolled, 78 (88.6%) of whom completed the 28 days of follow-up. Overall, 76 (97.4%) patients had adequate clinical and parasitological responses, and two patients had late parasitological failures. The initial therapeutic response was rapid, with 100% clearance of asexual parasitaemia within 48 h.


Conclusion Despite previous reports of declining chloroquine efficacy against P. vivax, CQ retains high therapeutic efficacy in southern Ethiopia, supporting the current national treatment guidelines. Ongoing clinical monitoring of CQ efficacy supported by advanced molecular methods is warranted to inform national surveillance and ensure optimal treatment guidelines.
title: Outside on the Inside: Musical improvisation according to contemporary materialist thought
Creators: name: Lovett, Matthew
Publisher: name: Goldsmiths, University of London
Year: 2018
Subjects: subject: Improvisation, Improvised Music, Music, Materialism, Philosophy, Speculative Realism

description: One of the precursors to this PhD project was an awareness that a great deal of
writing about music aesthetics, the practice of making music and the nature of
listening to music, is often either knowingly or unknowingly grounded in a set of
philosophical debates that predate (sometimes quite considerably) the music that is
being written about. As such, there is a sense in which critical perspectives on
improvised music practice, if they are to be relevant, need to take into account
more recent developments in philosophical and theoretical thought, and one of the
objectives of this study is to meet that challenge by mapping of some of the key
aspects of twentieth and twenty-first century thought that have their roots in what
could be described as ‘philosophies of immanence’ onto various aspects of
improvisation.

From the outset, this project is written from a maker’s perspective, and takes the
form of a piece of extended research that takes as its starting point the idea that
musical improvisation is a form of creative thinking in action. From this position, the
process of improvising and an improvised piece of music, to some extent bear the
traces of the thought that has given rise to both the music and the improvising
itself. By grounding the research in a set of the afore-mentioned ‘philosophies of
immanence’, it is therefore my intention to develop new ways of thinking about how
improvisation works, new ways to describe what is happening when we hear
musicians improvising, and new ways to understand what kinds of changes and
innovations are brought to bear on the resources and materials – in other words the
musical knowledge, the skills, the instruments, and a wider set of musical contexts
and environments – that musicians have at their disposal during an improvisation.
Additional file 4 of Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration
Creators: name: Morton, Katherine S.
name: Hartman, Jessica H.
name: Heffernan, Nathan
name: Ryde, Ian T.
name: Kenny-Ganzert, Isabel W.
name: Meng, Lingfeng
name: Sherwood, David R.
name: Meyer, Joel N.
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Neuroscience

description: Additional file 4: Fig. S4. Oxygen consumption rate normalized to worm number without accounting for worm size. Whole worm respirometry was performed with the Seahorse XF24 Bioanalyzer and reported as oxygen consumption rate normalized to the number of worms in each well. All wells from the same biological replicate were averaged to produce n=1 (One-way ANOVA, Tukey’s Post Hoc, *p<0.0332).
Shifting institutional culture to develop climate solutions with Open Science
Creators: name: Markowitz, Emily H.
name: Nojavan, Farnaz
name: Virdi, Makhan
name: Welch, Jessica Nicole
name: Verstaen, Juliette
name: Kross, Sean
name: Li, Bai
name: Burke, Devan
name: Doering, Kathryn
name: Hollister, Jeffrey W.
name: Clatterbuck, Corey
name: Robinson, Erin
name: Butland, Stefanie
name: Lowndes, Julia Stewart
name: London, Josh M.
name: Bradford, Amanda L.
name: Stevens, Molly H.
name: Davis, Alexandra
name: Barrett, Andrew P.
name: Holder, Anna M.
name: Rios, Adyan
name: Stawitz, Christine
name: Steiner, Erin
name: Hunzinger, Alexis
name: Siple, Margaret C.
name: Holmes, Elizabeth
name: Fenwick, Ileana
Publisher: name: Wiley
Year: 2024

description:
To address our climate emergency, "we must rapidly, radically reshape society"-Johnson & Wilkinson, All We Can Save. In science, reshaping requires formidable technical (cloud, coding, reproducibility) and cultural shifts (mindsets, hybrid collaboration, inclusion). We are a group of cross-government and academic scientists that are exploring better ways of working and not being too entrenched in our bureaucracies to do better science, support colleagues, and change the culture at our organizations. We share much-needed success stories and action for what we can all do to reshape science as part of the Open Science movement and 2023 Year of Open Science.
Dekarbonisierung Infrastrukturbauten: CO 2 Reduktionspotenzial und End of Life Szenarien für den Holzbau, Technischer Bericht – Teilprojekt 3
Creators: name: Chabrelie, Aude
name: Thömen, Heiko
Publisher: name: Bundesamt für Umwelt (BAFU)
Year: 2024

description: Zur Abschätzung des Dekarbonisierungspotentials, welches sich aus der Ausführung von Infrastruktur-bauten in Holz- statt in Betonbauweise ergibt, wurden an sechs exemplarischen Objektpaaren jeweils vereinfachte Ökobilanzierungen durchgeführt. Die Objekte in Betonausführung wurden überwiegend vom ASTRA zur Verfügung gestellt. In vier Fällen wurden die Varianten in Holzbauweise durch ein Holzbauingenieurbüro auf Konzeptstufe geplant, während für die Wildtierüberführungen und die Lärmschutzwände auf bereits umgesetzte Objekte zurückgegriffen werden konnte. Die vereinfachten Ökobilanzierungen ergaben, dass sich die Treibhausgasemissionen für Herstellung, Transport und Entsorgung der Baumaterialien (Module A1 bis A4 und C1 bis C4, mit Einbezug der Ersatzmaterialien für Sanierungen in diese Module) bei Ausführung in Holz- statt in Betonbauweise um 2 bis 70 % reduzieren lassen (Abb. 1), mit erheblichen Unterschieden zwischen den betrachteten Objekten. Werden die graue Energie und die Umweltbelastungen betrachtet, reduziert sich der Unterschied zwischen einer Holz- und einer Betonausführung deutlich. Die Fundamente sind in die Betrachtungen eingeschlossen, wobei gleiche Fundamente für Holz- und Betonbauweise angenommen wurden. Verkehrliche Auswirkungen sind nicht Teil der vorliegenden Studie.
Czech Farmers' Attitudes Towards Sustainable Agriculture and Water Management: A Statistical Analysis for Climate Change Adaptation Strategies - attachement to journal article
Creators: name: Bednář, Marek
name: Netopil, Patrik
name: Šarapatka, Bořivoj
name: Pavelková, Renata
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 300201
subject: Agricultural hydrology
classificationCode: 300202
subject: Agricultural land management
classificationCode: 300203
subject: Agricultural land planning
classificationCode: 300206
subject: Agricultural spatial analysis and modelling
classificationCode: 370299
subject: Climate change science not elsewhere classified
classificationCode: 410102
subject: Ecological impacts of climate change and ecological adaptation
classificationCode: 410199
subject: Climate change impacts and adaptation not elsewhere classified

description: This study investigates Czech farmers' attitudes towards sustainable agriculture and water management in response to climate change challenges. Using a combination of traditional statistical methods and innovative machine learning techniques, the research analyzed survey data from 1,176 farmers. Key findings reveal that the vast majority of farmers (98.4%) recognize the importance of water retention, with 79.2% willing to adopt nature-based measures. The study identifies significant differences between organic and conventional farmers' attitudes, as well as a positive correlation between farm size and willingness to invest in water management measures. Additionally, 91.67% of farmers perceive climate change as a threat. The research provides valuable insights for developing targeted agricultural policies and adaptation strategies in the Czech Republic, emphasizing the need for approaches tailored to specific farm characteristics and regional contexts.
Dr. Ludwig Schmitz-Kallenberg, Practica cancellariae apostolicae saeculi XV exeuntis
Creators: name: Meister, Aloys
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 20 Nr. 2 (1906): Römische Quartalschrift, Band 20, Heft 2
sj-docx-1-jmq-10.1177_10776990211021800 – Supplemental material for Why Retractions of Numerical Misinformation Fail: The Anchoring Effect of Inaccurate Numbers in the News
Creators: name: Stubenvoll, Marlis
name: Matthes, Jörg
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Education

description: Supplemental material, sj-docx-1-jmq-10.1177_10776990211021800 for Why Retractions of Numerical Misinformation Fail: The Anchoring Effect of Inaccurate Numbers in the News by Marlis Stubenvoll and Jörg Matthes in Journalism & Mass Communication Quarterly
sj-pdf-1-mdm-10.1177_0272989X221107902 – Supplemental material for PaCAR: COVID-19 Pandemic Control Decision Making via Large-Scale Agent-Based Modeling and Deep Reinforcement Learning
Creators: name: Guo, Xudong
name: Chen, Peiyu
name: Liang, Shihao
name: Jiao, Zengtao
name: Li, Linfeng
name: Yan, Jun
name: Huang, Yadong
name: Liu, Yi
name: Fan, Wenhui
Publisher: name: SAGE Journals
Year: 2022
Subjects: Health and Community Services
Public Health and Health Services not elsewhere classified
Sociological Methodology and Research Methods

description: Supplemental material, sj-pdf-1-mdm-10.1177_0272989X221107902 for PaCAR: COVID-19 Pandemic Control Decision Making via Large-Scale Agent-Based Modeling and Deep Reinforcement Learning by Xudong Guo, Peiyu Chen, Shihao Liang, Zengtao Jiao, Linfeng Li, Jun Yan, Yadong Huang, Yi Liu and Wenhui Fan in Medical Decision Making
Use and Evaluation of GANs for Synthetic Data Generation in Pharmacogenetics
Creators: name: Aeschbacher, Dominic
name: Meisner, Jessica
name: Miletic, Marko
name: Sariyar, Murat
Publisher: name: IOS Press
Year: 2024
Subjects: CTAB-GAN+
GAN
Pharmacogenetics (PGx)
synthetic data generation
tabular data

description: Pharmacogenetics (PGx) explores the influence of genetic variability on drug efficacy and tolerability. Synthetic Data Generation (SDG) has emerged as a promising alternative to the labor-intensive process of collecting real-world PGx data, which is required for high-qualitative prediction models. This study investigates the performance of two Generative Adversarial Network (GAN) models, CTGAN and CTAB-GAN+, in generating synthetic PGx data. The benchmarking is based on utility metrics (Hellinger distance and Random Forest accuracy) and ϵ-identifiability. Results demonstrate that synthetic data generated by CTAB-GAN+ can surpass the original dataset in terms of utility. For instance, CTAB-GAN+ achieves higher Random Forest accuracy compared to the original data, indicating better predictive performance. These improvements suggest that synthetic data not only capture the essential patterns of the original data but also enhance model generalization and prediction capabilities, providing a more robust training ground for machine learning models. Consequently, SDG offers a promising solution to address data scarcity and imbalance in pharmacogenetic research.
The Ethics of Repair
Creators: name: Hölling, Hanna Barbara
Year: 2024
Subjects: Repair
Ethics
conservation
material culture
performance

description: This talk explores the concept of repair, traditionally associated with fixing broken objects, and its implications for performance art and conservation practices. Starting with the etymology of “repair,” rooted in Latin meanings of restoration and renewal, the presentation probes how repair intersects with care ethics, aesthetics and conservation strategies. Drawing insights from cultural practices and thinkers like Yuriko Saito, it considers repair as a meditative act that tends to both material and human conditions. The talk invites participants to reflect on whether performance conservation can be framed as a form of repair and questions whether something must first be damaged to require such care. By rethinking repair, the discussion opens possibilities for integrating repair principles into experimental care practices and artistic performance conservation.
Cervical cancer prevention in Burkina Faso: a stakeholder’s collaboration for the development of awareness messaging
Creators: name: Ouedraogo, Samiratou
name: Kagoné, Samdapawindé Thérèse
name: Lompo, Olga Mélanie
name: Kaboré, Simon
name: Tiendrebeogo, Georges
name: Bamogo, Assanatou
name: Turcotte-Tremblay, Anne-Marie
name: Meda, Nicolas
name: Maiga, Mamoudou
Publisher: name: Frontiers
Year: 2024

description:
Background: Cervical Cancer stands as the second leading cause of both incident female cancers and deaths in Burkina Faso. Unfortunately, the prevention, early detection, and care of cervical cancers are suboptimal at individual, institutional, and national levels. In October 2023, we organized a stakeholder's workshop to develop cervical cancer awareness messaging for disease control in the country. Methods: A one-text workshop was organized with stakeholders working toward improving health in general or women's health and well-being. A participatory, learning, and adaptive approach was used to facilitate discussions and activities, ensuring the contribution of all participants. Contextual evidence-based and empirical elements about cervical cancer burden and preventive strategies were presented to the participants by key informants. These served as the foundation for a collaborative formulation of messaging content that aimed at raising awareness about cervical cancer. Results: Sixty-two participants from 28 organizations attended the workshop. They work mainly at local and international non-governmental organizations, civil society organizations, universities, university hospitals, research centers, and the Ministry of Health. During the first and second days of the workshop, the participants explored cervical cancer data, its preventive and treatment options available in Burkina Faso, communication strategies for behavioral change, and determinants of the use of prevention and health promotion services. During the following three days, 3 working groups were formed to define strategies, and key messages adapted to diverse tools and targeted audiences. All information was validated during plenary sessions before the end of the workshop and available to all participants and their organizations for cancer awareness activities. Conclusion: Upon conclusion of the workshop, the participants provided insightful information for the development of cervical awareness messaging in Burkina Faso. They formed the first community of practice to serve as a dynamic platform for implementation, monitoring, evaluation, and continued learning activities.
Fluxus Mystery Food : Konservendosen, die durch Ben Vautiers performativen Akt und George Maciunas Label-Design populär wurden
Creators: name: Hölling, Hanna Barbara
Publisher: name: Hatje Cantz
Year: 2024
Subjects: Foodart
Fluxus
Ben Vautier
FluxMysteryFood
Konservendosen
Maciunas

description: Ein Geheimnis umgibt das Flux Mystery Food – eine Dosennahrung, die der französische Künstler Ben Vautier 1963 auf dem Fluxus Festival in Nizza präsentierte. Ein Schwarz-Weiß- Foto zeigt Vautier, wie er den Inhalt einer unbeschrifteten Dose verzehrt. Nach dieser einmaligen und ein Stück weit in Vergessenheit geratenen Aktion putzte er sich angeblich die Zähne. Doch egal, ob er die unetikettierten Dosen nun aus ökonomischen oder ästhetischen Gründen verwendete – auf jeden Fall standen sie für eine faszinierende Erfahrung: Sie rückten die geschmackliche Wahrnehmung in den Vordergrund, offenbarten ihren Inhalt erst während des Verzehrs und unterliefen so die Dominanz des Visuellen.
sj-docx-1-hol-10.1177_09596836221106966 – Supplemental material for Assessment of the distribution of Pseudoryzomys simplex (Cricetidae, Sigmodontinae) in the Pampean region, central-east Argentina, in the late-Holocene
Creators: name: García-Morato, Sara
name: Lobo, Jorge M
name: Fernández-Jalvo, Yolanda
name: Montalvo, Claudia I
name: Fernández, Fernando J
Publisher: name: SAGE Journals
Year: 2022
Subjects: Geography
History

description: Supplemental material, sj-docx-1-hol-10.1177_09596836221106966 for Assessment of the distribution of Pseudoryzomys simplex (Cricetidae, Sigmodontinae) in the Pampean region, central-east Argentina, in the late-Holocene by Sara García-Morato, Jorge M Lobo, Yolanda Fernández-Jalvo, Claudia I Montalvo and Fernando J Fernández in The Holocene
Le (presunte) improvvisazioni simulate di Friedrich Kalkbrenner
Creators: name: Di Grazia, Gigliola
Publisher: name: Accademia Musicale Chigiana
Year: 2024

description: Recent studies have raised questions about the improvisational talent of virtuoso pianist Friedrich Kalkbrenner (1785-1849). Despite limited direct evidence, several scholars suggest that he simulated his improvisations (Gooley 2018, 23), possibly to conceal what has been described as a "handicap" (La Grandville 2014, 120). This hypothesis is mainly supported by two anecdotal accounts: one suggests that Kalkbrenner presented his performance of the Fantasia Effusio Musica at the Mendelssohn house as extemporaneous (Hiller 1884, 117–18), and another that he passed this practice on to his son Arthur to boost his reputation as a child prodigy (Berlioz 1842). This presentation aims to contextualize and moderate the controversy surrounding the alleged lack of improvisational ability of one of the most influential pianists and pedagogues of his era. In his Traité d’harmonie du Pianiste (1849), Kalkbrenner focused on teaching improvisation, offering practical, instrument-specific frameworks. Unpublished sources, including letters and reviews from non-musical journals, provide further insight into his improvisational practices. During his stay in London (1814–1824), Kalkbrenner frequently performed improvisations, which were often compared to those of Mozart and Beethoven in terms of skill. Concert reviews from 1824 in Ireland and Scotland offer valuable material for analysis, occasionally presenting contrasting perspectives on the same performances. Some accounts further support the theory of simulation or memorization, such as a reviewer who described one of Kalkbrenner’s improvisations as "the best-studied piece" (Dublin Evening Mail 1824). His correspondence reveals additional insights into his personal approach to improvisation, characterizing it as both complex and unpredictable, and susceptible to errors. In one letter, he notes that even Chopin's improvisations could be undermined by trivial details, such as "the color of a flower in a lady's hat in the audience" (Letter from Kalkbrenner to an unknown recipient, [1849]). These sources raise broader questions about the evolution of the concept of improvisation, while also linking it back to late 18th-century practices.
Clinical trial recruitment of people who speak languages other than English: a Children’s Oncology Group report
Creators: name: Montiel-Esparza, Raul
name: Pelletier, Wendy
name: Hillyer, Grace C
name: Kline, Cassie
name: Aristizabal, Paula
name: Velez, Maria C
name: Hall, Anurekha G
name: Kahn, Justine M
name: Santacroce, Sheila J
name: Solomon, Samrawit
name: Blazin, Lindsay J
name: Winestone, Lena E
name: Robles, Joanna M
name: Orjuela-Grimm, Manuela
name: Seif, Alix E
name: Fu, Cecilia
name: Ruiz, Jenny
name: Ortega, Maria
name: Beauchemin, Melissa P
Publisher: name: Oxford University Press (OUP)
Year: 2024

description:
BACKGROUND: Persons who speak languages other than English are underrepresented in clinical trials, likely in part because of inadequate multilevel resources. We conducted a survey of institutions affiliated with the Children's Oncology Group (COG) to characterize current research recruitment practices and resources regarding translation and interpretation services. METHODS: In October 2022, a 20-item survey was distributed electronically to institutions affiliated with COG to assess consent practices and resources for recruiting participants who speak languages other than English to COG trials. Descriptive statistics were used to summarize responses; responses were compared by institution size and type as well as respondent role. RESULTS: The survey was sent to 230 institutions, and the response rate was 60% (n = 139). In total, 60% (n = 83) of those respondents had access to short-form consent forms. Full consent form translation was required at 50% of institutions, and 12% of institutional review boards restricted use of centrally translated consent forms. Forty-six percent (n = 64) of institutions reported insufficient funding to support translation costs; 19% (n = 26) had access to no-cost translation services. Forty-four percent (n = 61) were required to use in-person interpreters for consent discussions; the most frequently cited barrier (56%) to obtaining consent was lack of available in-person interpreters. Forty-seven percent (n = 65) reported that recruiting persons who speak languages other than English to clinical trials was somewhat or very difficult. CONCLUSIONS: Institutions affiliated with COG face resource-specific challenges that impede recruitment of participants who speak languages other than English for clinical trials. These findings indicate an urgent need to identify strategies aimed at reducing recruitment barriers to ensure equitable access to clinical trials.
Czech Farmers' Attitudes Towards Sustainable Agriculture and Water Management: A Statistical Analysis for Climate Change Adaptation Strategies - attachement to journal article
Creators: name: Bednář, Marek
name: Netopil, Patrik
name: Šarapatka, Bořivoj
name: Pavelková, Renata
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 300201
subject: Agricultural hydrology
classificationCode: 300202
subject: Agricultural land management
classificationCode: 300203
subject: Agricultural land planning
classificationCode: 300206
subject: Agricultural spatial analysis and modelling
classificationCode: 370299
subject: Climate change science not elsewhere classified
classificationCode: 410102
subject: Ecological impacts of climate change and ecological adaptation
classificationCode: 410199
subject: Climate change impacts and adaptation not elsewhere classified

description: This study investigates Czech farmers' attitudes towards sustainable agriculture and water management in response to climate change challenges. Using a combination of traditional statistical methods and innovative machine learning techniques, the research analyzed survey data from 1,176 farmers. Key findings reveal that the vast majority of farmers (98.4%) recognize the importance of water retention, with 79.2% willing to adopt nature-based measures. The study identifies significant differences between organic and conventional farmers' attitudes, as well as a positive correlation between farm size and willingness to invest in water management measures. Additionally, 91.67% of farmers perceive climate change as a threat. The research provides valuable insights for developing targeted agricultural policies and adaptation strategies in the Czech Republic, emphasizing the need for approaches tailored to specific farm characteristics and regional contexts.