cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sustainable Soils: Reducing, Mitigating, and Adapting to Climate Change with Organic Agriculture
Creators: name: Niles, Meredith
Publisher: name: figshare
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Climate Science

description: Overview of the potential of organic agriculture to mitigate climate change.
Additional file 1 of Pain behaviors before and after treatment of oral disease in cats using video assessment: a prospective, blinded, randomized clinical trial
Creators: name: Watanabe, Ryota
name: Frank, Diane
name: Steagall, Paulo V
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: p values of behaviors that were not significantly associated with fixed factors. Table with individual behaviors and p values for group, time, group x time and gender comparisons.
Criteria for the use of existing biological samples from health studies for HBM analysis
Creators: name: Korkalainen, Merja
name: Rantakokko, Panu
name: Ruokojärvi, Päivi
name: Tolonen, Hanna
Publisher: name: Zenodo
Year: 2022
Subjects: biomonitoring
biological sample
sample collection
sample storage

description: In health surveys, especially in health examination surveys (HES), biological samples are commonly collected and often also stored for future use. This provides a possibility to extend the health surveys also to HBM if underlying criteria for the sample collection and supporting information is met.
 This document will provide a short overview of what is known about availability of stored samples in national HESs in Europe, what are the key criteria for samples when analysing the HBM4EU 1st priority chemicals, and what are the criteria for the use of stored biological samples from health studies for HBM analysis
Risk factors associated with recurrent cholera outbreaks in Borno and Adamawa states, northeast Nigeria
Creators: name: Cherono, Janet
Publisher: name: Loughborough University
Year: 2024
Subjects: classificationCode: 400513
subject: Water resources engineering

description: This study evaluates the risk factors leading to recurrent cholera outbreaks in Borno and Adamawa states, northeast Nigeria. The study focusses mainly on the two states most affected by the ongoing conflict, resulting to massive displacement of populations internally. The literature review and the methodology adopted for this study included review of existing secondary data relevant to the study area. The documents reviewed included materials such as journals, research papers, textbooks, published reports, articles, government press releases and publication on the activities of International Nongovernmental Organization. Materials were sourced through credible sites such as google scholar, research gate and the Loughborough university repository. Where relevant, data obtained from other similar contexts was used to corroborate the findings and draw conclusions. The study findings revealed that deficiency in water and sanitation infrastructure, congestion, displacement, rapid urbanization, the negative beliefs and practices, unclear guidelines on cholera control and prevention, the lack of knowledge on proper handwashing, environmental natural and man-made hazards amongst other factors contributing to cholera outbreaks. The lack of primary data posed as a major limitation to this study. Future social researchers can benefit more through collection of primary data to build on the findings and recommendations for this study. The study concludes with recommendations specific to the different players contributing to the cholera prevention and control strategies in the study locations. Further studies should be conducted to establish further to fill the knowledge gaps.
Quantification of polyphenols and flavonoid content and evaluation of anti-inflammatory and antimicrobial activities of Stenocereus stellatus extracts
Creators: name: Terrazas, Teresa
name: Soto-Cabrera, Diego
name: Salazar, Juan R.
name: Nogueda-Gutiérrez, Inés
name: Torres-Olvera, Mariana
name: Cerón-Nava, Anabelle
name: Rosales-Guevara, Juan
name: Rosas-Acevedo, Hortensia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry

description: The hexanic, ethyl acetate and methanolic extracts from branches of Stenocereus stellatus were tested in both the 12-O-tetradecanoylphorbol-13-acetate (TPA) – induced ear oedema model and antimicrobial activity assay. The % of oedema inhibition, the Minimum Inhibitory Concentration (MIC), as well as the polyphenolic and flavonoid content were determined. Also, extracts were analysed by gas chromatography–mass spectrometry (GC–MS). In TPA model, the three extracts showed moderate oedema inhibition. In the antimicrobial activity assay, methanolic extract shows better MIC against all strains. The lowest MICs were for Candida albicans (31 μg/mL) and Rhizopus sp. (15 μg/mL). Also, 50.78 mg eq. of gallic acid/g extract of polyphenol and 115.12 mg eq. of catequine/g extract of flavonoids content were founded in ethyl acetate extract. In the chromatographic analysis, β-sitosterol, β-amyrine, betulin and some other molecules were identified. The results show that S. stellatus possess antimicrobial activities against some fungus species.
Additional file 1 of Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults
Creators: name: Lin, Lisha
name: Kiryakos, Jenna
name: Ammous, Farah
name: Ratliff, Scott M.
name: Ware, Erin B.
name: Faul, Jessica D.
name: Kardia, Sharon L.R.
name: Zhao, Wei
name: Birditt, Kira S.
name: Smith, Jennifer A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
Quantitative 1H NMR analyses of the vegetable oils and GC validation from Aquivion perfluorosulfonic superacid as an effective catalyst for selective epoxidation of vegetable oils
Creators: name: Polese, Riccardo
name: Pintus, Elisa
name: Nuvoli, Luca
name: Tiana, Monica
name: Pintus, Salvatore
name: Satta, Giuseppe
name: Beccu, Andrea
name: Gaspa, Silvia
name: Carraro, Massimo
name: De Luca, Lidia
name: Azzena, Ugo
name: PISANO, Luisa
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences

description: The acid-promoted epoxidation of vegetable oils was studied using a variety acidic ion exchange resins as heterogeneous acid catalysts. Quantitative and selective epoxidation of a series of vegetable oils with different composition of saturated, mono-, di- and tri-unsaturated fatty acids was obtained upon identification of the more efficient catalyst and experimental conditions. Furthermore, optimized reaction conditions were successfully applied to the epoxidation of a waste cooking oil, thus extending our procedure to the valorization of a biowaste, an area of increasing importance within a more sustainable society. The use of quantitative 1H NMR besides making accurate evaluation of the amounts of reagents to be employed and of the selectivity, allowed facile and rapid quantification of mono-, di- and tri-epoxides, thus providing an indirect indication on the fatty acid composition of the vegetable oils, even in the presence of very low quantities of linolenic acid.
Additional file 1 of MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions
Creators: name: Wang, Geng
name: Kim, Tae-Hwan
name: Zhixiu Li
name: Cortes, Adrian
name: Kwangwoo Kim
name: Bang, So-Young
name: Leo, Paul
name: Brown, Matthew A.
name: Huji Xu
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
Neonatal outcomes following elective caesarean delivery at term: a hospital-based cohort study
Creators: name: O’Neill, Sinéad M.
name: Khashan, Ali S.
name: Finn, Daragh
name: Collins, Aedin
name: O’Donoghue, Keelin
name: Dempsey, Eugene
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Medicine
Engineering

description: Objective: To assess neonatal outcomes following elective caesarean delivery (CD) at term (≥37 + 0 weeks gestation).Methods: A retrospective cohort study was conducted in a single Irish maternity hospital. Elective CDs at term between August 2008 and July 2012 were reviewed. Outcome measures were admission to the neonatal intensive care unit (NICU), length of stay, respiratory complications, hypoglycaemia, jaundice, newborn sepsis and medical interventions.Results: A total of 4242 women had an elective CD at term, accounting for approximately 15% of all term deliveries. Admission rate to the NICU at 37 weeks gestation was 21.8% versus 10% at 39 weeks (p for trend <0.0001). Similar trends of decreasing risk with later gestational age were noted for the other outcomes. An increased odds of admission to the NICU at 37 weeks [adjusted odds ratio (OR) 2.48 (95% CI 1.28, 4.79)] and at 38 weeks [OR 1.34, 95% CI 1.02, 1.77] compared to the reference of 39 weeks gestation was found.Conclusions: This study supports evidence that, with regard to neonatal outcome, 39 weeks gestational age is the optimal delivery time. Heightened awareness of the increased risk of neonatal morbidity, when delivery is performed electively before 39 weeks, is warranted among healthcare workers.
Sparse Vector Autoregressive Modeling
Creators: name: Davis, Richard A.
name: Pengfei Zang
name: Zheng, Tian
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: The vector autoregressive (VAR) model has been widely used for modeling temporal dependence in a multivariate time series. For large (and even moderate) dimensions, the number of the AR coefficients can be prohibitively large, resulting in noisy estimates, unstable predictions, and difficult-to-interpret temporal dependence. To overcome such drawbacks, we propose a two-stage approach for fitting sparse VAR (sVAR) models in which many of the AR coefficients are zero. The first stage selects nonzero AR coefficients based on an estimate of the partial spectral coherence (PSC) together with the use of BIC. The PSC is useful for quantifying the conditional relationship between marginal series in a multivariate process. A refinement second stage is then applied to further reduce the number of parameters. The performance of this two-stage approach is illustrated with simulation and real data examples. Supplementary materials for this article are available online.
Pennariidae McCrady 1859
Creators: name: Watson, Jeanette E.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Hydrozoa
Anthoathecata
Pennariidae

description: Family Pennariidae McCrady, 1859    Diagnosis. (modified after Calder 2010). Capitate hydroids with erect colonies; stems monosiphonic, branches giving rise to hydranth pedicels, perisarc firm. Hydranth naked, spindle-shaped, with an aboral whorl of long filiform tentacles semicapitate distally, an oral whorl of short, capitate tentacles. Eumedusa without manubrium, with four radial canals and four rudimentary tentacles bulbs, velum not penetrated.
description: Published as part of Watson, Jeanette E., 2015, Five athecate hydroids (hydrozoa: anthoathecata) from south-eastern australia, pp. 19-26 in Memoirs of Museum Victoria 73 on page 24, DOI: 10.24199/j.mmv.2015.73.03, http://zenodo.org/record/10886644
Additional file 1 of Development of the Clinical Gestalt Assessment: a visual clinical global impression scale for Proteus syndrome
Creators: name: Ours, Christopher A.
name: Hodges, Mia B.
name: Oden, Neal
name: Sapp, Julie C.
name: Biesecker, Leslie G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Fig. S1. Cases reviewed by raters.
Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development
Creators: name: Zhang, Ji
name: Loyd, Melanie R
name: Randall, Mindy S
name: Morris, John J
name: Jayesh G Shah
name: Ney, Paul A
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Hematology
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Retinoblastoma-1 (RB1), and the RB1-related proteins p107 and p130, are key regulators of the cell cycle. Although RB1 is required for normal erythroid development in vitro, it is largely dispensable for erythropoiesis in vivo. The modest phenotype caused by RB1 deficiency in mice raises questions about redundancy within the RB1 family, and the role of RB1 in erythroid differentiation. Here we show that RB1 is the major pocket protein that regulates terminal erythroid differentiation. Erythroid cells lacking all pocket proteins exhibit the same cell cycle defects as those deficient for RB1 alone. RB1 has broad repressive effects on gene transcription in erythroid cells. As a group, RB1-repressed genes are generally well expressed but downregulated at the final stage of erythroid development. Repression correlates with E2F binding, implicating E2Fs in the recruitment of RB1 to repressed genes. Merging differential and time-dependent changes in expression, we define a group of approximately 800 RB1-repressed genes. Bioinformatics analysis shows that this list is enriched for terms related to the cell cycle, but also for terms related to terminal differentiation. Some of these have not been previously linked to RB1. These results expand the range of processes potentially regulated by RB1, and suggest that a principal role of RB1 in development is coordinating the events required for terminal differentiation.
Convenient In-Flow Preparation of Cr(II) Chloride for Nozaki–Hiyama–Kishi Reaction
Creators: name: Voltrova, Svatava
name: Jiri Srogl
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Science Policy
subject: Marine Biology
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: A flow preparation of chromous chloride has been introduced as a viable alternative to the batch protocol. Activity of the prepared reagent has been demonstrated in the traditional Nozaki–Hiyama–Kishi reaction.
Additional file 1 of Using video reflexive ethnography to explore the use of variable rate intravenous insulin infusions
Creators: name: Iflaifel, Mais
name: Lim, Rosemary
name: Crowley, Clare
name: Greco, Francesca
name: Iedema, Rick
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1.
Additional file 2 of Using video reflexive ethnography to explore the use of variable rate intravenous insulin infusions
Creators: name: Iflaifel, Mais
name: Lim, Rosemary
name: Crowley, Clare
name: Greco, Francesca
name: Iedema, Rick
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 2.
STUDIO CLINICO_ REGISTRO IMAGING 502.2021
Creators: name: MultiMedica - Data Management
Publisher: name: Zenodo
Year: 2024

description: STUDIO CLINICO_ REGISTRO IMAGING 502.2021

TITOLO : REGISTRO IMAGING -  Registro per la Valutazione Con Imaging Multimodale del danno microvascolare retinico in pazienti diabetici

Promotore: MultiMedica

Studio osservazionale prospettico monocentrico

Lettera richiesta al CE di settembre 2021

Protocollo v 1.0 del 15.9.2021 e v 2.0 9.2.22

Verbale CE 3-2022 E 36-2022
A Convenient In-Flow Preparation of Cr(II) Chloride for Nozaki–Hiyama–Kishi Reaction
Creators: name: Voltrova, Svatava
name: Jiri Srogl
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Science Policy
subject: Marine Biology
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: A flow preparation of chromous chloride has been introduced as a viable alternative to the batch protocol. Activity of the prepared reagent has been demonstrated in traditional Nozaki-Hiyama-Kishi reaction.
Additional file 1 of Evaluation of Problem-Based Learning implementation in a College of Medicine, Kingdom of Saudi Arabia: a cross sectional comparative study
Creators: name: Almulhem, Manahel A.
name: Almulhem, Jwaher A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Distribution of the facilitators (N = 46) and students (N = 324) by demographic, professional and academic characteristics.
Additional file 2 of Evaluation of Problem-Based Learning implementation in a College of Medicine, Kingdom of Saudi Arabia: a cross sectional comparative study
Creators: name: Almulhem, Manahel A.
name: Almulhem, Jwaher A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Appendix 1: The web-based questionnaire. Appendix 2: The facilitators’ characteristics and the small group learning scale. Appendix 3: The facilitators’ characteristics and the problem case scenario scale. Appendix 4: The facilitators’ characteristics and the facilitator role scale. Appendix 5: The students’ characteristics and the small group learning scale. Appendix 6: The students’ characteristics and the problem case scenario scale. Appendix 7: The students’ characteristics and the facilitator role scale. Appendix 8: Comparison between the facilitators’ and students’ evaluations.
Platform Writers and the Production of Digital Literature: The Professionalism of Female Pesantren Novelists in Indonesia
Creators: name: Ismah, Nor
Publisher: name: International Quarterly for Asian Studies
Year: 2024

description: The new global genres of “chick lit” and “teen lit” in the early twenty-first century led to the rise of a new generation of Muslim women writers in Indonesia. They gained public attention, particularly from teen readers, by publishing Islamic novels and popular pesantren (Islamic boarding school) novels. Focusing on two online platforms for digital literature, the Komunitas Bisa Menulis and Halaqah 1001 Aksara as case studies, this study employs online observation of the platforms, content analysis of the works, and interviews with three young Muslim women writers from the pesantren tradition to explore their experiences of embracing socio-religious changes and technological developments in Indonesia. The article aims to answer three questions. Firstly, how and why do Muslim women writers from the pesantren tradition choose to publish their works on online platforms? Secondly, what are the predominant themes, genres and ideological messages present in their writing? And finally, to what extent do these platforms benefit women in developing their professionalism?
description: International Quarterly for Asian Studies, Vol. 54 No. 4 (2023): Mosques and Meeting Rooms: Professional Lives of Muslim Women
Additional file 1 of Immune microenvironment, homologous recombination deficiency, and therapeutic response to neoadjuvant chemotherapy in triple-negative breast cancer: Japan Breast Cancer Research Group (JBCRG)22 TR
Creators: name: Ueno, Takayuki
name: Kitano, Shigehisa
name: Masuda, Norikazu
name: Ikarashi, Daiki
name: Yamashita, Makiko
name: Chiba, Tomohiro
name: Kadoya, Takayuki
name: Bando, Hiroko
name: Yamanaka, Takashi
name: Ohtani, Shoichiro
name: Nagai, Shigenori
name: Nakayama, Takahiro
name: Takahashi, Masato
name: Saji, Shigehira
name: Aogi, Kenjiro
name: Velaga, Ravi
name: Kawaguchi, Kosuke
name: Morita, Satoshi
name: Haga, Hironori
name: Ohno, Shinji
name: Toi, Masakazu
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. Image analysis. Representative image of immunofluorescence with the following markers: CD3 (blue), CD4 (yellow), CD8 (red), FoxP3 (pink), CD204 (green), and cytokeratin (brown) (A); tissue segmentation of the intratumoral (red) and stromal (green) areas (B); cell segmentation (C) and cell phenotyping (D) which merged with tissue segmentation (E): cancer cells (orange), CD4+ T cells (yellow), CD8+ T cells (red), CD204+ cells (green), other stromal cells (gray). Figure S2. Immune cell density according to pathological response in each treatment group: group A1 (A), group A2 (B), group B1 (C), group B2 (D). Figure S3. Immune phenotype and pCR. (A) Immune inflamed, high cell density in both cancer cell nests and stromal regions; immune excluded, low cell density in cancer cell nests and high cell density in stromal regions; immune desert, low cell densities in both cancer cell nests and stromal regions. (B) Immune phenotype for CD4+ T cells. (C) Immune phenotype for CD8+ T cells. (D) pCR rate according to immune phenotype for CD4+ T cells and CD8+ T cells.
Additional file 1 of Effective delivery of miR-150-5p with nucleus pulposus cell-specific nanoparticles attenuates intervertebral disc degeneration
Creators: name: Jiang, Hua
name: Qin, Hongyu
name: Yang, Qinghua
name: Huang, Longao
name: Liang, Xiao
name: Wang, Congyang
name: Moro, Abu
name: Xu, Sheng
name: Wei, Qingjun
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: Supplementary Material 1.
Digital Connectivity as a Springboard to Professionalisation: Social Media Groups of Pakistani Women
Creators: name: Muhammad Din, Faiza
Publisher: name: International Quarterly for Asian Studies
Year: 2024

description: In Pakistan, female entrepreneurs and earning women encounter considerable challenges when trying to enter male-dominated job markets. Many turn to women-only social media groups as a forum to discuss these obstacles and share strategies for overcoming them. Unlike conventional, more bureaucratic networking avenues such as chambers of commerce, these online platforms offer flexibility and continuous connectivity. This proves especially beneficial for women during significant life events like maternity or caregiving breaks. In Muslim-majority countries, these groups also serve as platforms for exchanging culturally and religiously relevant business practices, including discussions on halal investments and Sharia-compliant entrepreneurship. This study employs online ethnography and interviews with key stakeholders in some of Pakistan’s most prominent women-focused online networking groups. While one might assume that the primary aim of such professional networks is to discuss business growth, cutting-edge research or technology, these groups actually thrive on a common language, shared challenges and shared values. The article begins by exploring the concept of professionalism and the role of community and networking in career advancement. It then delves into the specific challenges that make networking difficult for women in Pakistan but paradoxically act as a glue binding them together in these online spaces.
description: International Quarterly for Asian Studies, Vol. 54 No. 4 (2023): Mosques and Meeting Rooms: Professional Lives of Muslim Women
Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites
Creators: name: Bogen, Kenneth T.
name: Heilman, Jacqueline M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biochemistry

description: A 1999 California state agency cancer potency (CP) evaluation of methyl tert-butyl ether (MTBE) assumed linear risk extrapolations from tumor data were plausible because of limited evidence that MTBE or its metabolites could damage DNA, and based such extrapolations on data from rat gavage and rat and mouse inhalation studies indicating elevated tumor rates in male rat kidney, male rat Leydig interstitial cells, and female rat leukemia/lymphomas. More recent data bearing on MTBE cancer potency include a rodent cancer bioassay of MTBE in drinking water; several new studies of MTBE genotoxicity; several similar evaluations of MTBE metabolites, formaldehyde, and tert-butyl alcohol or TBA; and updated evaluations of carcinogenic mode(s) of action (MOAs) of MTBE and MTBE metabolite's. The lymphoma/leukemia data used in the California assessment were recently declared unreliable by the U.S. Environmental Protection Agency (EPA). Updated characterizations of MTBE CP, and its uncertainty, are currently needed to address a variety of decision goals concerning historical and current MTBE contamination. To this end, an extensive review of data sets bearing on MTBE and metabolite genotoxicity, cytotoxicity, and tumorigenicity was applied to reassess MTBE CP and related uncertainty in view of MOA considerations. Adopting the traditional approach that cytotoxicity-driven cancer MOAs are inoperative at very low, non-cytotoxic dose levels, it was determined that MTBE most likely does not increase cancer risk unless chronic exposures induce target-tissue toxicity, including in sensitive individuals. However, the corresponding expected (or plausible upper bound) CP for MTBE conditional on a hypothetical linear (e.g., genotoxic) MOA was estimated to be ∼2 × 10–5 (or 0.003) per mg MTBE per kg body weight per day for adults exposed chronically over a lifetime. Based on this conservative estimate of CP, if MTBE is carcinogenic to humans, it is among the weakest 10% of chemical carcinogens evaluated by EPA.
Additional file 1 of Acupuncture for allergic rhinitis: a systematic review and meta-analysis
Creators: name: He, Min
name: Qin, Weishan
name: Qin, Zongshi
name: Zhao, Changqing
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. PRISMA 2009 checklist.
Insights on the structural perturbations in human MTHFR Ala222Val mutant by protein modeling and molecular dynamics
Creators: name: P.A. Abhinand
name: Faraz Shaikh
name: Soumendranath Bhakat
name: Radadiya, Ashish
name: L.V.K.S. Bhaskar
name: Anamik Shah
name: P.K. Ragunath
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions. The Ala222Val polymorphism of human MTHFR encodes a thermolabile protein associated with increased risk of neural tube defects and cardiovascular disease. Experimental studies have shown that the mutation does not affect the kinetic properties of MTHFR, but inactivates the protein by increasing flavin adenine dinucleotide (FAD) loss. The lack of completely solved crystal structure of MTHFR is an impediment in understanding the structural perturbations caused by the Ala222Val mutation; computational modeling provides a suitable alternative. The three-dimensional structure of human MTHFR protein was obtained through homology modeling, by taking the MTHFR structures from Escherichia coli and Thermus thermophilus as templates. Subsequently, the modeled structure was docked with FAD using Glide, which revealed a very good binding affinity, authenticated by a Glide XP score of −10.3983 (kcal mol−1). The MTHFR was mutated by changing Alanine 222 to Valine. The wild-type MTHFR-FAD complex and the Ala222Val mutant MTHFR-FAD complex were subjected to molecular dynamics simulation over 50 ns period. The average difference in backbone root mean square deviation (RMSD) between wild and mutant variant was found to be ~.11 Å. The greater degree of fluctuations in the mutant protein translates to increased conformational stability as a result of mutation. The FAD-binding ability of the mutant MTHFR was also found to be significantly lowered as a result of decreased protein grip caused by increased conformational flexibility. The study provides insights into the Ala222Val mutation of human MTHFR that induces major conformational changes in the tertiary structure, causing a significant reduction in the FAD-binding affinity.
Presentation of the Ukranian National Chapter at the CoARA National Chapters Exchange Forum 2024
Creators: name: Berezko, Oleksandr
Publisher: name: Zenodo
Year: 2024

description: Slides presented at the CoARA National Chapters Exchange Forum 2024.  A description of the event is available here: https://coara.eu/news/building-a-stronger-network-coara-national-chapters-convene-for-a-first-exchange-forum/.
Additional file 2 of Acupuncture for allergic rhinitis: a systematic review and meta-analysis
Creators: name: He, Min
name: Qin, Weishan
name: Qin, Zongshi
name: Zhao, Changqing
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Search strategies and items used in each database.
Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development
Creators: name: Zhang, Ji
name: Loyd, Melanie R
name: Randall, Mindy S
name: Morris, John J
name: Jayesh G Shah
name: Ney, Paul A
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: Retinoblastoma-1 (RB1), and the RB1-related proteins p107 and p130, are key regulators of the cell cycle. Although RB1 is required for normal erythroid development in vitro, it is largely dispensable for erythropoiesis in vivo. The modest phenotype caused by RB1 deficiency in mice raises questions about redundancy within the RB1 family, and the role of RB1 in erythroid differentiation. Here we show that RB1 is the major pocket protein that regulates terminal erythroid differentiation. Erythroid cells lacking all pocket proteins exhibit the same cell cycle defects as those deficient for RB1 alone. RB1 has broad repressive effects on gene transcription in erythroid cells. As a group, RB1-repressed genes are generally well expressed but downregulated at the final stage of erythroid development. Repression correlates with E2F binding, implicating E2Fs in the recruitment of RB1 to repressed genes. Merging differential and time-dependent changes in expression, we define a group of approximately 800 RB1-repressed genes. Bioinformatics analysis shows that this list is enriched for terms related to the cell cycle, but also for terms related to terminal differentiation. Some of these have not been previously linked to RB1. These results expand the range of processes potentially regulated by RB1, and suggest that a principal role of RB1 in development is coordinating the events required for terminal differentiation.
A fragmentation study on four C19-diterpenoid alkaloids by electrospray ionization ion-trap time-of-flight tandem mass spectrometry
Creators: name: Xing-Long Chen
name: Chang-An Geng
name: Chen, Ji-Jun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: High-resolution electrospray ionization ion-trap time-of-flight tandem mass spectrometry (HR-ESI-IT-TOF-MSn) in positive-ion mode was used to determine the accurate masses and fragmentation pathways of four C19-diterpenoid alkaloids, aconitine (1), yunnaconitine (2), crassicauline A (3), and benzoylmesaconine (4). The [M+H]+ ions of compounds 1–4 were readily observed in conventional single-stage mass spectrometry. Based on the MS1–6 analyses, detailed fragmentation rules of the four compounds were proposed. The neutral losses of AcOH, MeOH, H2O, CO, C2H4, PhCOOH and p-OMePhCOOH segments were the characteristic eliminations from the precursor ions due to the presence of acetyl, methoxyl, hydroxyl, N-ethyl, benzoyl and p-methoxyl-benzoyl units in the structures. Benefited from the high resolution of the mass analyzer, the loss of 28 Da corresponding to CO or CH4 segment in product ions was unambiguously distinguished. The losing sequence of the main substituent groups was summarized as: C(8)-acetyl>C(16)-methotyl>C(15)-hydroxyl>C(6)-methoxyl>C(1)-methoxyl/C(3)-hydroxyl>C(18)-methoxyl>>C(13)-hydroxyl. The sequential loss of (16)-methoxyl moiety and CO (generating from enol–ketone tautomerism) groups could be recognized as the characteristic eliminations for the compounds with C(16)-methoxyl and C(15)-hydroxyl groups simultaneously. The application of HR-ESI-IT-TOF-MSn technique to investigate the fragmentation of C19-diterpenoid alkaloids provided useful information to understand their fragmentation behaviors.
Chemical constituents from Euphorbia wallichii and their biological activities
Creators: name: Yang, Yong-Ping
name: Li, Xiao-Li
name: Xiao, Wei-Lie
name: Da-Song Yang
name: Peng, Wei-Bing
name: Ke-Chun Liu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: One rare diterpenoid which was an unusual phorbol derivative possessing a 5-ene-7-oxo functional group, wallichiioid A (1), and 17 known compounds (2–18) were isolated from the aerial parts of Euphorbia wallichii. The structures and relative configuration of these compounds were elucidated on the basis of extensive spectroscopic interpretation. All the known compounds were isolated from E. wallichii for the first time. Diterpenoids 1–5 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, HeLa, and P388) and showed IC50 values in the range of 8.19–29.72 μg/mL. The antiangiogenic activities of diterpenoids 1–5 were also evaluated using a zebrafish model.
Additional file 3 of Acupuncture for allergic rhinitis: a systematic review and meta-analysis
Creators: name: He, Min
name: Qin, Weishan
name: Qin, Zongshi
name: Zhao, Changqing
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Meta-analysis result for this review.
Additional file 1 of Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders
Creators: name: Kung, Po-Lun
name: Chou, Tsui-Wen
name: Lindman, Marissa
name: Chang, Nydia P.
name: Estevez, Irving
name: Buckley, Benjamin D.
name: Atkins, Colm
name: Daniels, Brian P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Primer sequences for qRT-PCR. Table S2. Curated psychiatric disorder-associated gene list.
DYNAMIC LINKAGES BETWEEN PSYCHOLOGICAL CONTRACT BREACH AND EMPLOYEES' WORKPLACE BEHAVIORS IN POWER SECTOR OF PAKISTAN
Creators: name: Sajjad Ahmad Jan, Wali Rahman
Publisher: name: TuEngr Group
Year: 2020
Subjects: Psychological contract breach
Employees' Workplace behaviour
Workplace spirituality, Human resource management (HRM)
Power sector.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 3, 11A03S: 1-12
Insights on the structural perturbations in human MTHFR Ala222Val mutant by protein modeling and molecular dynamics
Creators: name: P.A. Abhinand
name: Faraz Shaikh
name: Soumendranath Bhakat
name: Radadiya, Ashish
name: L.V.K.S. Bhaskar
name: Anamik Shah
name: P.K. Ragunath
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions. The Ala222Val polymorphism of human MTHFR encodes a thermolabile protein associated with increased risk of neural tube defects and cardiovascular disease. Experimental studies have shown that the mutation does not affect the kinetic properties of MTHFR, but inactivates the protein by increasing flavin adenine dinucleotide (FAD) loss. The lack of completely solved crystal structure of MTHFR is an impediment in understanding the structural perturbations caused by the Ala222Val mutation; computational modeling provides a suitable alternative. The three-dimensional structure of human MTHFR protein was obtained through homology modeling, by taking the MTHFR structures from Escherichia coli and Thermus thermophilus as templates. Subsequently, the modeled structure was docked with FAD using Glide, which revealed a very good binding affinity, authenticated by a Glide XP score of −10.3983 (kcal mol−1). The MTHFR was mutated by changing Alanine 222 to Valine. The wild-type MTHFR-FAD complex and the Ala222Val mutant MTHFR-FAD complex were subjected to molecular dynamics simulation over 50 ns period. The average difference in backbone root mean square deviation (RMSD) between wild and mutant variant was found to be ~.11 Å. The greater degree of fluctuations in the mutant protein translates to increased conformational stability as a result of mutation. The FAD-binding ability of the mutant MTHFR was also found to be significantly lowered as a result of decreased protein grip caused by increased conformational flexibility. The study provides insights into the Ala222Val mutation of human MTHFR that induces major conformational changes in the tertiary structure, causing a significant reduction in the FAD-binding affinity.
INNOVATSION TAʼLIM TEXNOLOGIYALARIDAN FOYDALANIB BOʻLAJAK FIZIKA OʻQITUVCHILARINING KASBIY KOMPETENTLIGINI RIVOJLANTIRISH METODIKASI
Creators: name: Aminov, Alijon
Publisher: name: Zenodo
Year: 2024

description: O'qituvchilarning kasbiy kompetensiyasi ularning pedagogik faoliyatni amalga oshirishga tayyorligini, shuningdek uning kasbiy xususiyatlarini aks ettiradi. Shu sababli, hozirgi vaqtda o'qituvchilarga kasbiy kompetensiyalarni rivojlantirish uchun katta talablar qo'yiladi. Kasbiy kompetentsiya muammosi ko'plab mahalliy va xorijiy olimlarning ishlarida faol o'rganilmoqda, Maqola boʻlajak fizika oʻqituvchisini kasbiy kompetentsiyaning muhim tarkibiy qismi bo'lgan innovatsion taʼlim texnologiyalaridan foydalanishni rivojlantirishga bag'ishlagan.
The (extra) burden of COVID-19 for people with Parkinson's (Poster)
Creators: name: Noordegraaf, Marina
Publisher: name: Zenodo
Year: 2020
Subjects: Parkinson's
COVID-19
Corona
Parkinson

description: This is the CC BY 4.0. visual interpretation of Marina Noordegraaf (@Sparks4PD) of the article by Bastiaan R. Bloem and R. Helmich. The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities. Journal of Parkinson’s Disease 10 (2020) 351–354. https://doi.org/10.3233/JPD-202038 The poster is available in: English: The (extra) burden of COVID-19 for people with Parkinson's
 Dutch (Nederlands): De (extra) lasten van de COVID-19 pandemie voor mensen met parkinson
 Spanish (espanol): La (extra) carga del COVID-19 en personas con enfermedad de parkinson
Additional file 1 of LinG3D: visualizing the spatio-temporal dynamics of clonal evolution
Creators: name: Hu, Anjun
name: Ojwang’, Awino Maureiq E.
name: Olumoyin, Kayode D.
name: Rejniak, Katarzyna A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
Additional file 4 of Acupuncture for allergic rhinitis: a systematic review and meta-analysis
Creators: name: He, Min
name: Qin, Weishan
name: Qin, Zongshi
name: Zhao, Changqing
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 4. Result of subgroup analysis according to different time-points and countries.
A METHOD FOR DETERMINING THE THERMOPHYSICAL PROPERTIES OF A CONSTRUCTION OBJECT
Creators: name: Panfilov Stepan Aleksandrovich, Lomshin Mikhail Ivanovich
Publisher: name: TuEngr Group
Year: 2020
Subjects: Non-destructive testing method
Heat loss
Thermal conductivity
Specific heat
Know-how.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 3, 11A03T: 1-11
Highly‑efficient sustainable ionic thermoelectric materials using lignin‑derived hydrogels
Creators: name: Muddasar, Muhammad
name: Menéndez, Nicolás
name: Quero, Ángela
name: A. Nasiri, Mohammad
name: Cantarero, Andrés
name: García-Cañadas, Jorge
name: Gómez, Clara M.
name: COLLINS, MAURICE
name: Culebras, Mario
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 40
subject: Engineering

description: The efficient and economical conversion of low-grade waste heat into electricity has promising potential to combat the greenhouse effect and expedite the shift towards sustainable development. This study presents an innovative and appealing approach through the utilization of lignin, an abundant waste product derived from the paper and pulp industry, to develop hydrogels as compelling and sustainable materials for application in ionic thermoelectricity. Various compositions were evaluated to examine the impacts of varying lignin concentrations, types of electrolytes, concentrations of crosslinkers, and electrolyte concentrations on the ionic thermoelectric performance of the hydrogels. The optimized lignin-derived hydrogel, infiltrated with a 6 M KOH electrolyte, demonstrates high ionic conductivity (226.5 mS/cm) and a superior Seebeck coefficient of 13 mV/K. This results in a remarkable power factor (3831 µW/m·K2 ) that leads to an impressive Figure of merit (ZTi ) (3.75), surpassing most of the existing state-of-the-art materials and making it the most efficient sustainable ionic thermoelectric material reported until now. These findings underscore the exceptional performance of lignin-based hydrogels in the realm of low-grade waste energy harvesting applications. The present study contributes to address the challenges posed by waste heat through effectively harnessing low-grade waste heat through the utilization of sustainable lignin-based hydrogels while reducing the reliance on fossil fuels and minimizing greenhouse gas emissions.
Development and characterization of lysine-methotrexate conjugate for enhanced brain delivery
Creators: name: Singh, Vijay Kumar
name: Subudhi, Bharat Bhusan
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Background information: Methotrexate (MTX), an anticancer drug of choice, has poor permeability across blood-brain barrier (BBB) making it unsuitable for brain tumor application. Its brain availability and scope of application was improved by preparation of reversible conjugate with lysine by capitalizing the endogenous transport system of lysine at BBB.Methods: To enhance its delivery to brain, MTX was reversibly conjugated with l-Lysine by an amide linkage. It was characterized by advanced spectroscopy techniques including IR, NMR and MS. Furthermore, conjugate was assessed for stability, toxicity and drug release ability. In vivo distribution studies were done by radioscintigraphy study using 99mTc radioisotope.Results: The structure of prodrug was confirmed by 1H-NMR, 13C-NMR and Mass. The m/e (mass to charge ratio) fragment was found at [M + H] 711.32 in Mass spectra. Stability and metabolic studies suggested that conjugate was stable at physiological pH (in Phosphate buffer pH 7.4 t1/2 is 70.25 ± 2.17 h and in plasma t1/2 is 193.57 ± 2.03 min) and circulated adequately to release MTX slowly in brain. In vivo biodistribution study showed that prodrug significantly increased the level of MTX in brain when compared with pharmacokinetic parameter of parent drug.Conclusion: The brain permeability of MTX was enhanced significantly by this conjugate.