cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.
Creators: name: Goldstein, J. L.
name: Maeda, N.
name: Herz, J.
name: Ishibashi, S.
name: Brown, M. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Apolipoprotein E (apoE) is hypothesized to mediate lipoprotein clearance by binding to two receptors: (i) the low density lipoprotein receptor (LDLR) and (ii) a chylomicron remnant receptor. To test this hypothesis, we have compared plasma lipoproteins in mice that are homozygous for targeted disruptions of the genes for apoE [apoE(-/-)], the LDLR [LDLR(-/-)], and both molecules [poE(-/-); LDLR(-/-)]. On a normal chow diet, apoE(-/-) mice had higher mean plasma cholesterol levels than LDLR(-/-) mice (579 vs. 268 mg/dl). Cholesterol levels in the apoE(-/-); LDLR(-/-) mice were not significantly different from those in the apoE(-/-) mice. LDLR(-/-) mice had a relatively isolated elevation in plasma LDL, whereas apoE(-/-) mice had a marked increase in larger lipoproteins corresponding to very low density lipoproteins and chylomicron remnants. The lipoprotein pattern in apoE(-/-); LDLR(-/-) mice resembled that of apoE(-/-) mice. The LDLR(-/-) mice had a marked elevation in apoB-100 and a modest increase in apoB-48. In contrast, the apoE(-/-) mice had a marked elevation in apoB-48 but not in apoB-100. The LDLR(-/-); apoE(-/-) double homozygotes had marked elevations of both apolipoproteins. The observation that apoB-48 increases more dramatically with apoE deficiency than with LDLR deficiency supports the notion that apoE binds to a second receptor in addition to the LDLR. This conclusion is also supported by the observation that superimposition of a LDLR deficiency onto an apoE deficiency [apoE(-/-); LDLR(-/-) double homozygotes] does not increase hypercholesterolemia beyond the level observed with apoE deficiency alone.
Curvature dark energy reconstruction through different cosmographic distance definitions
Creators: name: Capozziello, Salvatore
name: De Laurentis, Mariafelicia
name: Luongo, Orlando
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the context of $f(\mathcal{R})$ gravity, dark energy is a geometrical fluid with negative equation of state. Since the function $f(\mathcal{R})$ is not known \emph{a priori}, the need of a model independent reconstruction of its shape represents a relevant technique to determine which $f(\mathcal{R})$ model is really favored with respect to others. To this aim, we relate cosmography to a generic $f(\mathcal R)$ and its derivatives in order to provide a model independent investigation at redshift $z \sim 0$. Our analysis is based on the use of three different cosmological distance definitions, in order to alleviate the duality problem, i.e. the problem of which cosmological distance to use with specific cosmic data sets. We therefore consider the luminosity, $d_L$, flux, $d_F$, and angular, $d_A$, distances and we find numerical constraints by the Union 2.1 supernovae compilation and measurement of baryonic acoustic oscillations, at $z_{BAO}=0.35$. We notice that all distances reduce to the same expression, i.e. $d_{L;F;A}\sim\frac{1}{\mathcal H_0}z$, at first order. Thus, to fix the cosmographic series of observables, we impose the initial value of $H_0$ by fitting $\mathcal H_0$ through supernovae only, in the redshift regime $z<0.4$. We find that the pressure of curvature dark energy fluid is slightly lower than the one related to the cosmological constant. This indicates that a possible evolving curvature dark energy realistically fills the current universe. Moreover, the combined use of $d_L,d_F$ and $d_A$ shows that the sign of the acceleration parameter agrees with theoretical bounds, while its variation, namely the jerk parameter, is compatible with $j_0>1$. Finally, we infer the functional form of $f(\mathcal{R})$ by means of a truncated polynomial approximation, in terms of fourth order scale factor $a(t)$.
description: 10 pages, 4 figures, to appear in Annalen der Physik
Vaccines for bacterial sexually transmitted infections: a realistic goal?
Creators: name: Elkins, C.
name: Sparling, P. F.
name: Wyrick, P. B.
name: Cohen, M. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Bacterial infections of the genital tract (gonorrhea, chlamydia, chancroid, syphilis) are common and cause significant morbidity. Their importance is heightened by recent appreciation of their roles in facilitation of transmission of the human immunodeficiency virus (HIV). Each is capable of causing repeated infections, suggesting lack of permanent broadly effective immunity. An effective vaccine has yet to be developed for any of these diseases. Rapid progress in understanding the molecular basis for pathogenesis of infection, including mechanisms for escape from otherwise effective immune surveillance and mechanisms for causing injury to host cells, has stimulated renewed efforts to make vaccines for some of these infections. Progress has been greatest for Neisseria gonorrhoeae and Chlamydia trachomatis. Present emphasis is on the major or principal outer membrane proteins of N. gonorrhoeae and C. trachomatis, based on evidence for neutralizing antibodies directed against surface-exposed variable domains of each of these proteins. Other surface-exposed proteins, including the iron-repressible transferrin receptor in gonococci and certain heat-shock proteins in chlamydia, also may be targets for vaccines. Although much remains to be learned, cautious optimism is warranted.
title: Solar Degradation and Stability of Lead‐Free Light Absorber Cs₂AgBiBr₆ in Ambient Conditions
Creators: name: Jöckel, Dennis Michael
name: Yoon, Songhak
name: Frebel, Alexander
name: Neguse, Samuel Meles
name: Rossa, Jürgen Dieter
name: Bett, Alexander Jürgen
name: Schubert, Martin
name: Widenmeyer, Marc
name: Balke-Grünewald, Benjamin
name: Weidenkaff, Anke
Publisher: name: Wiley-VCH
Year: 2024

description: As numerous studies on highly efficient perovskite solar cells have been conducted on lead‐based light absorbers, such as MAPbI₃ and FAPbI₃, increasing concerns are rising regarding toxicity and stability issues. One of the most prominent and promising lead‐free alternatives is the double‐perovskite Cs₂AgBiBr₆, which is well‐suited for multi‐junction solar cells considering its relatively large indirect bandgap of around 1.95–2.05 eV. Despite distinctive reports on its performance under ambient conditions, the demonstrated stability has not yet been conclusively clarified. Within this study, the degradation behavior of Cs₂AgBiBr₆ single crystals is investigated under different ambient environments, such as AM1.5g solar irradiation, aquatic conditions, and humidity. The corresponding samples are analyzed by using Raman, UV–vis, energy‐dispersive X‐Ray, and micro‐photoluminescence spectroscopies together with X‐Ray diffraction. High intrinsic stability of Cs₂AgBiBr₆ in ambient conditions and severe degradation in aquatic conditions are observed. Furthermore, surface morphology alterations are found during the simulated solar irradiation indicating photo‐accelerated degradation behavior. In the results of this study, it is clearly implied that intense research efforts need to be put into sealing the Cs₂AgBiBr₆ layer in solar cells with the goal of protecting it from humidity and water intrusion simultaneously, therefore avoiding photo‐accelerated degradation.
Understanding the genetics of mitochondrial disorders
Creators: name: Vishu Gupta
Publisher: name: Zenodo
Year: 2023
Subjects: Mitochondria
Genomics
Indian population

description: Appendix 2 : ACMG/AMP classification of all 892 variants in 127 nuclear genes implicated in mitochondrial disorders Appendix 4 : List of all the 2689 variants identified in mitochondrial DNA in Indian population Appendix 5 : Annotation of all the 2689 variants identified in mitochondrial DNA in Indian population
Cyanidin-3-glucoside reduces cell migration and inflammatory profile of acute leukemia cells
Creators: name: Assaf, Luciene
name: Makyiama, Edson Naoto
name: Almeida, Beatriz
name: de Almeida, Jeremias Martins
name: da Silva Gonçalves, Carlos Eduardo
name: de Freitas, Sumara
name: Amon, Rosana Lopes Rodrigues
name: Neves, Bruna Roberta Oliveira
name: Rogero, Marcelo Macedo
name: Fock, Ricardo Ambrosio
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Anthocyanins, water-soluble flavonoids found in fruits and vegetables, exhibit diverse biological activities, with cyanidin being the most common pigment. While cyanidin’s chemo preventive and ­antioxidant activity is well-studied, its impact on inflammatory profile and migration capacity of leukemic cells are less understood. This study evaluates the effects of Cyanidin-3-glucoside (C3G) on the inflammatory mechanisms influencing leukemic cell migration. Results show that C3G doses up to 50 µM do not affect cell metabolism, viability, or cell cycle phases. C3G significantly reduces TNF-α, IL-8, CCL2 production, and the p-NFκB/NFκB ratio in LPS (Lipopolysaccharide)-challenged cells. It also diminishes migration rates in response to LPS or fMLP (N-formyl-methionyl-leucyl-phenylalanine) stimulation and reduces Rho-GTP expression. Thus, C3G modifies the inflammatory and migration properties of leukemic cells, highlighting the potential of anthocyanins as a complementary therapy and an avenue for further therapeutic intervention.
title: The practice of translation
title: Stages, procedures, and strategies
titleType: AlternativeTitle
title: Η πράξη της μετάφρασης
title: Στάδια, διαδικασίες και στρατηγικές
titleType: AlternativeTitle
Creators: name: Kelandrias, Panagiotis
Publisher: name: Kallipos, Open Academic Editions
Year: 2022
Subjects: Μετάφραση
Διαμεσολάβηση
Δεοντολογία
Κειμενικός τύπος
Κειμενικό είδος
Νόρμα
Μακροστρατηγικές
Μικροστρατηγικές
Μεταφραστική δράση
Μεταφραστικά δίκτυα
Διαπραγμάτευση
Κείμενο αφετηρίας
Κείμενο υποδοχής
Translation
Mediation
Ethics
Text type
Text genre
Norm
Macrostrategies
Microstrategies
Translation brief
Translational action
Translation networks
Negotiation
Source-text
Target-text
Κειμενικές λειτουργίες
Text functions
Μεταφραστικές οδηγίες

description: The aim of the electronic textbook entitled “The practice of translation” is to present to the reader and especially to the students the practice of translation and all the details concerning the stages of the translational action, from the moment the translation of a source-text is commissioned to the moment of final checking and delivery of the target-text. Although ‘practice-oriented’ in the sense that it presents, analyses and comments on translating, this online textbook documents and explains the description of the stages of the translational action with reference to theoretical models or, better still, theoretical approaches, seeking to demonstrate that translating is an intentional, conscious process which requires that the translator is aware of what (s)he is doing, how and why (s)he e is doing it each time (s)he engages in mediating between two languages and cultures.
description: Το ηλεκτρονικό σύγγραμμα με τίτλο Η πράξη της μετάφρασης έχει ως στόχο να παρουσιάσει στον/στην αναγνώστη/στρια και ειδικότερα στους/στις φοιτητές/τριες την πράξη της μετάφρασης και όλες τις λεπτομέρειες σχετικά με τα στάδια του μεταφραστικού ενεργήματος, από τη στιγμή που ξεκινάει η ανάθεση της μετάφρασης ενός κειμένου αφετηρίας έως τη στιγμή του τελικού ελέγχου και της παράδοσης του κειμένου υποδοχής. Αν και «πρακτικού» προσανατολισμού, με την έννοια ότι παρουσιάζει, αναλύει και σχολιάζει τα περί του μεταφράζειν, το παρόν ηλεκτρονικό σύγγραμμα τεκμηριώνει και εξηγεί την περιγραφή των σταδίων του μεταφραστικού ενεργήματος με αναφορές σε θεωρητικά μοντέλα ή, καλύτερα, σε θεωρητικές προσεγγίσεις επιδιώκοντας να καταδείξει ότι το μεταφράζειν είναι μια εμπρόθετη, συνειδητή διαδικασία η οποία απαιτεί από πλευράς του μεταφραστή επίγνωση του τι πράττει, πώς πράττει και γιατί πράττει με τον έναν ή τον άλλο τρόπο κάθε φορά που αναλαμβάνει να «μεσολαβήσει» ανάμεσα σε δύο γλώσσες και κουλτούρες.
Supernovae at the cosmic dawn
Creators: name: Chen, Ke-Jung
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Modern cosmological simulations predict that the first generation of stars formed with a mass scale around 100 solar masses about 300-400 million years after the Big Bang. When the first stars reached the end of their lives, many of them might have died as energetic supernovae that could have significantly affected the early Universe via injecting large amounts of energy and metals into the primordial intergalactic medium. In this paper, we review the current models of the first supernovae by discussing on the relevant background physics, computational methods, and the latest results.
description: 54 pages, 21 figures, Review for the International Journal of Modern Physics D, World Scientific Publishing Company, Singapore
A mouse model for beta 0-thalassemia.
Creators: name: Smithies, O.
name: Lewis, J.
name: Maeda, N.
name: Detloff, P. J.
name: Yang, B.
name: Kirby, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: We have used a "plug and socket" targeting technique to generate a mouse model of beta 0-thalassemia in which both the b1 and b2 adult globin genes have been deleted. Mice homozygous for this deletion (Hbbth-3/Hbbth-3) die perinatally, similar to the most severe form of Cooley anemia in humans. Mice heterozygous for the deletion appear normal, but their hematologic indices show characteristics typical of severe thalassemia, including dramatically decreased hematocrit, hemoglobin, red blood cell counts, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, as well as dramatically increased reticulocyte counts, serum bilirubin concentrations, and red cell distribution widths. Tissue and organ damage typical of beta-thalassemia, such as bone deformities and splenic enlargement due to increased hematopoiesis, are also seen in the heterozygous animals, as is spontaneous iron overload in the spleen, liver, and kidneys. The mice homozygous for the b1 and b2 deletions should be of great value in developing therapies for the treatment of thalassemias in utero. The heterozygous animals will be useful for studying the pathophysiology of thalassemias and have the potential of generating a model of sickle cell anemia when mated with appropriate transgenic animals.
Quest for identity in Chimamanda Ngozi Adichie's Half of a Yellow Sun
Creators: name: Azhagunatchiar, SM
name: Dr. A., Anitha
Publisher: name: Zenodo
Year: 2024

description: The paper examines the search for identity against the backdrop of the Nigerian Civil War from the novel Half of a Yellow Sun by Chimamanda Ngozi Adichie. And it follows the novel’s major characters, Olanna, Richard, and Ugwu, as they strive to define themselves in the midst of great social and political instability. It explores how war and warfare affect people's cultural and personal identities through their experiences. The journeys of the protagonists show how difficult it is to define oneself and find a place in the turmoil. It investigates how historical events influence the characters identities, as well as how Half of a Yellow Sun represents the difficulties of forming an identity in a world that is changing.
Magnetic horizons of ultra-high energy cosmic rays
Creators: name: Batista, Rafael Alves
name: Sigl, Guenter
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The propagation of ultra-high energy cosmic rays in extragalactic magnetic fields can be diffusive, depending on the strength and properties of the fields. In some cases the propagation time of the particles can be comparable to the age of the universe, causing a suppression in the flux measured on Earth. In this work we use magnetic field distributions from cosmological simulations to assess the existence of a magnetic horizon at energies around 10$^{18}$ eV.
description: 4 pages, 2 figures. Proceedings of the Particles and Nuclei International Conference (PANIC 2014)
A multimerizing transcription factor of sea urchin embryos capable of looping DNA.
Creators: name: Zeller, R. W.
name: Kirchhamer, C. V.
name: Griffith, J. D.
name: Moore, J. G.
name: Davidson, E. H.
name: Britten, R. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: SpGCF1 is a recently cloned sea urchin transcription factor that recognizes target sites in several different sea urchin genes. We find that in gel-shift experiments this factor is able to multimerize. A quantitative simulation of the gel-shift results suggests that SpGCF1 molecules that are bound to DNA target sites may also bind to one another, thus associating several DNA probe molecules. SpGCF1 might therefore be able to loop DNA molecules bearing its target sites at distant locations. We demonstrate this prediction by electron microscopy, and using the well-characterized cis-regulatory domain of the CyIIIa cytoskeletal actin gene, we show that the loop conformations predicted from the known SpGCF1 target site locations are actually formed in vitro. We speculate that the multimerization of this factor in vivo may function to bring distant regions of extended regulatory domains into immediate proximity so that they can interact with one another.
title: A Simple Synthesis of 1,2-Dihydropentalene and its Substitution Products
Creators: name: Kaiser, Reinhard
name: Hafner, Klaus
Publisher: name: Wiley
Year: 2023

description: Whereas thermolysis of 6-(4-amino-1,3-butadienyl)fulvenes yields azulenes [¹], it is not unexpected that the corresponding reaction of 6-(2 aminovinyl)fulvenes (1) does not lead to the desired but presumably highly thermolabile pentalene (2) [²].
Hua type beta-integrals and projective systems of measures on flag spaces
Creators: name: Neretin, Yury A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 33B15, 14M15

description: We construct a family of measures on flag spaces (or, equivalently, on the spaces of upper-triangular matrices) compatible with respect to natural projections. We obtain an $n(n-1)/2$-parametric family of beta-integrals over space of upper-triangular matrices of size $n$.
description: 9pp
title: Πειραματική μελέτη της ήχο-απορροφητικής ικανότητας πορωδών υλικών
title: Experimental study of the sound-absorbing ability of porous materials
titleType: AlternativeTitle
Creators: name: Γιαννουλάκη, Αδαμαντίνη
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Διάκενο αέρος
Πάχος υλικών
Πορώδες υλικά
Πορώδη - ινώδη υλικά
Συντελεστής απορρόφησης
Σωλήνας Kund

description: Ο πιο αποτελεσματικός τρόπος για τον έλεγχο των επιπέδων θορύβου σε πολλούς τομείς, όπως της αρχιτεκτονικής, της αυτοκινητοβιομηχανίας, του ηχητικού εξοπλισμού καθώς και η διαμόρφωση της ακουστικής ενός συγκεκριμένου χώρου, όπως ένα θέατρο, μια αίθουσα μουσικής, ένα στούντιο, επιτυγχάνεται κυρίως με την χρήση ηχοαπορροφητικών υλικών. Οι πορώδης απορροφητές ίνας χρησιμοποιούνται ευρέως λόγω της εξαιρετικής ηχοαπορροφητικής τους απόδοσης και του χαμηλού κόστους. Μέσω της μελέτης μας θα εξετάσουμε τις ιδιότητες ηχοαπορρόφησης υλικών με ανοιχτές πορώδεις δομές χρησιμοποιώντας ακουστικούς σωλήνες εμπέδησης «Kundt tubes» και τη μέθοδο συνάρτησης μεταφοράς (transfer function). Οι σωλήνες εμπέδησης χρησιμοποιούνται ευρέως για τη μέτρηση των συντελεστών ηχοαπορρόφησης ακουστικών υλικών συναρτήσει της συχνότητας. H μελέτη διερευνά επίσης την απόδοση των πορωδών υλικών με διαφορετική πυκνότητα και ίδιο πάχος, με διάκενο αέρα μεταξύ του υλικού δείγματος και του στερεού τερματικού τοιχώματος του σωλήνα και τέλος διερευνά την ηχοαπορροφητική τους ικανότητα όταν τα δείγματα έχουν την ίδια πυκνότητα αλλά διαφορετικό πάχος. Η επαναληψιμότητα των μετρήσεων μας μέσω των σωλήνων εμπέδησης προσφέρει αξιοπιστία στα αποτελέσματα. Ωστόσο, υπάρχει πιθανότητα η μέτρηση των συντελεστών ηχοαπορρόφησης που λαμβάνονται με τη χρήση της μεθόδου σωλήνων εμπέδησης να έχουν κάποιες αποκλίσεις σε σύγκριση με του κατασκευαστή εξαιτίας της προετοιμασίας του δείγματος και της τοποθέτησης του ή λόγω διαφορετικής μεθόδου μέτρησης. Η απόδοση των υλικών σύμφωνα με τα χαρακτηριστικά τους και τα αποτελέσματα που αποκτήσαμε μας δίνουν σημαντικά στοιχεία τα οποία μπορούμε να εκμεταλλευτούμε στην εφαρμογή τους ώστε να πετύχουμε την μέγιστη απόδοση τους. Για τους λόγους αυτούς πραγματοποιούνται πολλές μελέτες για τη μελέτη ανοικτών πορωδών υλικών που η εφαρμογή τους μπορεί να μειώσει τα επίπεδα θορύβου.
Discovery of a deep, low mass ratio overcontact binary GSC 03517-00663
Creators: name: Guo, D. -F.
name: Li, K.
name: Hu, S. -M.
name: Jiang, Y. -G.
name: Gao, D. -Y.
name: Chen, X.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: When observing the blazars, we identified a new eclipsing binary GSC 03517-00663. The light curves of GSC 03517-00663 are typical EW-type light curves. Based on the observation using the 1m telescope at Weihai Observatory of Shandong University, complete VRI light curves were determined. Then, we analyzed the multiple light curves using the W-D program. It is found that GSC 03517-00663 has a mass ratio of q=0.164 and a contact degree of f=69.2%. GSC 03517-00663 is a deep, low mass ratio overcontact binary. The light curves of GSC 03517-00663 show strong O'Connell effect, it was explained by employing a dark spot on the secondary component.
description: Accepted by Research in Astronomy and Astrophysics, 8 pages, 6 figures
Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane.
Creators: name: Satoh, M.
name: Kanwar, Y. S.
name: Kumar, A.
name: Reeves, W. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The pathogenesis of systemic lupus erythematosus is thought to be primarily under genetic control, with environmental factors playing a secondary role. However, it has been shown recently that intraperitoneal injection of pristane (2,6,10,14-tetramethylpentadecane) induces autoantibodies typical of lupus in BALB/c mice, a strain not usually considered to be genetically susceptible to the disease. In this study, the induction of autoimmune disease by pristane was investigated. BALB/c mice receiving pristane were tested for autoantibody production and histopathological evidence of glomerulonephritis. Six of 11 mice developed IgM anti-single-stranded DNA antibodies shortly after receiving pristane and 4 developed IgM anti-histone antibodies, but anti-double-stranded DNA antibodies were absent. IgG anti-DNA and anti-histone antibodies were absent. In contrast, the lupus-associated anti-nuclear ribonucleoprotein/Sm and anti-Su autoantibodies produced by these mice were predominantly IgG. In addition to autoantibodies, most of the mice developed significant proteinuria. Light microscopy of the kidney showed segmental or diffuse proliferative glomerulonephritis. Electron microscopy showed subepithelial and mesangial immune-complex deposits and epithelial foot process effacement. Immunofluorescence revealed striking glomerular deposition of IgM, IgG, and C3 with a mesangial or mesangiocapillary distribution. Thus, pristane induces immune-complex glomerulonephritis in association with autoantibodies typical of lupus in BALB/c mice. These data support the idea that lupus is produced by an interplay of genetic and environmental factors and that unlike the MRL or (NZB x W)F1 mouse models, in which genetic susceptibility factors are of primary importance, environmental factors are of considerable importance in the autoimmune disease of pristane-treated BALB/c mice.
title: Pseudoprogression prediction in high grade primary CNS tumors by use of radiomics
Creators: name: Ari, Asena Petek
name: Akkurt, Burak Han
name: Musigmann, Manfred
name: Mammadov, Orkhan
name: Blömer, David A.
name: Kasap, Dilek N. G.
name: Henssen, Dylan J. H. A.
name: Nacul, Nabila Gala
name: Sartoretti, Elisabeth
name: Sartoretti, Thomas
name: Backhaus, Philipp
name: Thomas, Christian
name: Stummer, Walter
name: Heindel, Walter
name: Mannil, Manoj
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 610 Medicine and health

description: Our aim is to define the capabilities of radiomics and machine learning in predicting pseudoprogression development from pre-treatment MR images in a patient cohort diagnosed with high grade gliomas. In this retrospective analysis, we analysed 131 patients with high grade gliomas. Segmentation of the contrast enhancing parts of the tumor before administration of radio-chemotherapy was semi-automatically performed using the 3D Slicer open-source software platform (version 4.10) on T1 post contrast MR images. Imaging data was split into training data, test data and an independent validation sample at random. We extracted a total of 107 radiomic features by hand-delineated regions of interest (ROI). Feature selection and model construction were performed using Generalized Boosted Regression Models (GBM). 131 patients were included, of which 64 patients had a histopathologically proven progressive disease and 67 were diagnosed with mixed or pure pseudoprogression after initial treatment. Our Radiomics approach is able to predict the occurrence of pseudoprogression with an AUC, mean sensitivity, mean specificity and mean accuracy of 91.49% [86.27%, 95.89%], 79.92% [73.08%, 87.55%], 88.61% [85.19%, 94.44%] and 84.35% [80.19%, 90.57%] in the full development group, 78.51% [75.27%, 82.46%], 66.26% [57.95%, 73.02%], 78.31% [70.48%, 84.19%] and 72.40% [68.06%, 76.85%] in the testing group and finally 72.87% [70.18%, 76.28%], 71.75% [62.29%, 75.00%], 80.00% [69.23%, 84.62%] and 76.04% [69.90%, 80.00%] in the independent validation sample, respectively. Our results indicate that radiomics is a promising tool to predict pseudo-progression, thus potentially allowing to reduce the use of biopsies and invasive histopathology.
description: Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022.
TABOO AND ITS FEATURES
Creators: name: Abdiolimova, Qizlarxon
name: Qahhorova, Mavluda
Publisher: name: Zenodo
Year: 2024

description: This paper investigates the nature of taboo in both English and Uzbek. It shows that there are certain points of similarity and difference between the two languages in using euphemisms. The paper starts with some introductory remarks, two sections and a conclusion. The article discusses euphemism: its definition, classification, nature and relationship with certain figures of speech.
Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.
Creators: name: Zhong, S.
name: Campbell-Burk, S.
name: Carpenter, J. W.
name: Quilliam, L. A.
name: South, T. L.
name: Rabun, K. M.
name: Der, C. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Although Ras residue phenylalanine-156 (F156) is strictly conserved in all members of the Ras superfamily of proteins, it is located outside of the consensus GDP/GTP-binding pocket. Its location within the hydrophobic core of Ras suggests that its strict conservation reflects a crucial role in structural stability. However, mutation of the equivalent residue (F157L) in the Drosophila Ras-related protein Rap results in a gain-of-function phenotype, suggesting an alternative role for this residue. Therefore, we have introduced an F156L mutation into Ras to evaluate the role of this residue in Ras structure and function. Whereas introduction of this mutation activated the transforming potential of wild-type Ras, it did not impair that of oncogenic Ras. Further, Ras (156L) exhibited an extremely rapid off rate for bound GDP/GTP in vitro and showed increased levels of Ras.GTP in vivo. To determine the structural basis for these altered properties, we used high-resolution nuclear magnetic resonance spectroscopy. The F156L mutation caused loss of contact with residues 6, 23, 55, and 79, resulting in disruption of secondary structure in alpha-helix 1 and in beta-sheets 1-5. These major structural changes contrast with the isolated alterations induced by oncogenic mutation (residues 12 or 61) that perturb GTPase activity, and instead, weaken Ras contacts with Mg2+ and its guanine nucleotide substrate and result in increased rates of GDP/GTP dissociation. Altogether, these observations demonstrate the essential role of this conserved residue in Ras structure and its function as a regulated GDP/GTP switch.
Characterization of repetitive DNA in the Mycoplasma genitalium genome: possible role in the generation of antigenic variation.
Creators: name: Bailey, C. C.
name: Peterson, S. N.
name: Jensen, J. S.
name: Hutchison, C. A.
name: Bott, K. F.
name: King, E. S.
name: Borre, M. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: We have characterized a family of repetitive DNA elements with homology to the MgPa cellular adhesion operon of Mycoplasma genitalium, a bacterium that has the smallest known genome of any free-living organism. One element, 2272 bp in length and flanked by DNA with no homology to MgPa, was completely sequenced. At least four others were partially sequenced. The complete element is a composite of six regions. Five of these regions show sequence similarity with nonadjacent segments of genes of the MgPa operon. The sixth region, located near the center of the element, is an A+T-rich sequence that has only been found in this repeat family. Open reading frames are present within the five individual regions showing sequence homology to MgPa and the adjacent open reading frame 3 (ORF3) gene. However, termination codons are found between adjacent regions of homology to the MgPa operon and in the A+T-rich sequence. Thus, these repetitive elements do not appear to be directly expressible protein coding sequences. The sequence of one region from five different repetitive elements was compared with the homologous region of the MgPa gene from the type strain G37 and four newly isolated M. genitalium strains. Recombination between repetitive elements of strain G37 and the MgPa operon can explain the majority of polymorphisms within our partial sequences of the MgPa genes of the new isolates. Therefore, we propose that the repetitive elements of M. genitalium provide a reservoir of sequence that contributes to antigenic variation in proteins of the MgPa cellular adhesion operon.
Completion of strategy documents for each application area
Creators: name: I.FAST WP12 members
Publisher: name: Zenodo
Year: 2024

description: IFAST Task 12.1 is studying novel and important applications of particle accelerators in the health, environmental, imaging and radioisotope production areas and has identified those with the most potential. For these, it has developed strategies for delivering these applications. This report will describe the applications and the strategies for delivering them.
Cadmium exposure induced oxidative stress and histopathological disruption in the body wall of the freshwater leech Limnatis nilotica (Savigny, 1822)
Creators: name: Khaled, I
name: Ben Ahmed, R
name: Saidi, I
name: Pacioglu, O
name: Harrath, AH
Publisher: name: Invertebrate Survival Journal
Year: 2023

description: Cadmium (Cd) is considered as one of the most highly toxic heavy metal that is released into the environment on a large scale, and its concentrations in water have significantly increased as a result of human activities. In particular, contamination of rivers and drinking water may easily occur, especially in locations close to industry or mines. In this study, we examined the impact of Cd exposure on the body wall of the freshwater leech Limnatis nilotica at concentrations of 100, 200, and 300 µg/l. The findings showed that the exposure caused histopathological changes as well as oxidative stress (increased malondialdehyde concentrations (MDA)) and changes in antioxidant activity (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx)). In fact, numerous histological changes were observed, such as cuticle deterioration, a marked increase in the number of secretory cells, increased mucus production, vacuolization of the epithelium, altered epithelial cell borders, and mucus cell hyperplasia. The histological results are consistent with the biochemical findings because we found that MDA levels significantly increased in a dose-dependent manner. Additionally, the Cd exposure disrupted the levels of the antioxidant levels. Indeed, SOD, CAT, and Gpx activities were increased in the group treated with the lower dose (100 g/l), whereas their levels dramatically decreased at higher Cd doses (200 and 300 g/l). Therefore, the presence of this heavy metal in freshwater habitats may have severe ecological risks that may lead to leech aquatic habitat destruction and fragmentation.
description: Invertebrate Survival Journal, Vol 20 No 1 (2023)
Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.
Creators: name: Robinson, I. M.
name: Monck, J. R.
name: Wightman, R. M.
name: Fernandez, J. M.
name: Finnegan, J. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: "Snapshot" images of localized Ca2+ influx into patch-clamped chromaffin cells were captured by using a recently developed pulsed-laser imaging system. Transient opening of voltage-sensitive Ca2+ channels gave rise to localized elevations of Ca2+ that had the appearance of either "hotspots" or partial rings found immediately beneath the plasma membrane. When the Ca2+ imaging technique was employed in conjunction with flame-etched carbon-fiber electrodes to spatially map the release sites of catecholamines, it was observed that the sites of Ca2+ entry and catecholamine release were colocalized. These results provide functional support for the idea that secretion occurs from "active zone"-like structures in neuroendocrine cells.
Η έμφυλη κυβερνοβία κατά των γυναικών και των ανήλικων κοριτσιών
Creators: name: Σαραντή, Ναταλία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Κυβερνοβία
subject: Κυβερνοέγκλημα
subject: Ηλεκτρονικό έγκλημα
subject: Έμφυλη βία
subject: Γυναικοκτονία
subject: Revenge porn
subject: Cyber stalking
subject: Cyber harassment

description: Η παρούσα διπλωματική εργασία πραγματεύεται το ζήτημα της Έμφυλης Κυβερνοβίας σε βάρος των γυναικών και των ανήλικων κοριτσιών και αναλύεται σε τέσσερα κεφάλαια. Αρχικά, γίνεται λόγος για την έμφυλη βία και τις έννοιες που σχετίζονται με αυτή καθώς και για τη Νομοθεσία προστασίας των θυμάτων. Στο δεύτερο κεφάλαιο παρουσιάζεται η Κυβερνοβία, οι εκφάνσεις της και το Νομοθετικό πλαίσιο αντιμετώπισής της. Το τρίτο κεφάλαιο αποτελεί τον συνδετικό κρίκο πρώτου και δεύτερου κεφαλαίου καθώς, εντοπίζοντας το ιδιαίτερο χαρακτηριστικό της έμφυλης διάστασης του φαινομένου της Κυβερνοβίας, παρουσιάζει λεπτομερώς την Έμφυλη Κυβερνοβία, αναφέροντας όλες τις μορφές που έχουν έως και σήμερα εμφανισθεί, επισκοπώντας κάθε σχετικό και εξειδικευμένο Νομοθετικό κείμενο και σχολιάζοντας την τρέχουσα Νομολογιακή πρακτική. Τέλος, στο τέταρτο κεφάλαιο, ακολουθούν συμπερασματικές παρατηρήσεις και συστάσεις.
Visible-frequency metasurfaces for broadband anomalous reflection and high-efficiency spectrum splitting
Creators: name: Li, Zhongyang
name: Palacios, Edgar
name: Butun, Serkan
name: Aydin, Koray
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Ultrathin metasurfaces have recently emerged as promising materials to enable novel, flat optical components and surface-confined, miniature photonic devices. However, experimental realization of high-performance metasurfaces at visible frequencies has been a significant challenge due to high plasmonic losses and difficulties in high-uniformity nanofabrication. Here, we propose a highly-efficient yet simple metasurface design comprising of single gradient antenna as unit cell. We demonstrate visible broadband (450 - 850 nm) anomalous reflection and spectrum splitting with 85% conversion efficiency. Average power ratio of anomalous reflection to the strongest diffraction was calculated to be ~ 103 and measured to be ~ 10. The anomalous reflected photons and spectrum splitting performance have been visualized using CCD and characterized using angle-resolved measurement setup. Metasurface design proposed here is a clear departure from conventional metasurfaces utilizing multiple, anisotropic resonators, and could enable high-efficiency, broadband metasurfaces for achieving directional emitters, polarization/spectrum splitting surfaces for spectroscopy and photovoltaics.
Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.
Creators: name: Boubnov, N. V.
name: Hall, K. T.
name: Hendrickson, E. A.
name: He, D. M.
name: Benjamin, D. M.
name: Wills, Z.
name: Lee, S. E.
name: Band, H.
name: Reeves, W.
name: Pulaski, C. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Two ionizing radiation-sensitive (IRs) and DNA double-strand break (DSB) mutants, sxi-3 and sxi-2, were shown to be severely deficient in a DNA end binding activity, similar to a previously described activity of the Ku autoantigen, correlating with the xrs (XRCC5) mutations. Cell fusions with xrs-6, another IRs, DSB repair-deficient cell line, defined these sxi mutants in the XRCC5 group. sxi-3 cells have low expression levels of the p86Ku mRNA. Introduction of the Ku p86 gene, but not the p70 Ku gene, complemented the IRs, DNA end binding, and variable (diversity) joining [V(D)J] recombination signal and coding junction deficiencies of sxi-3. Thus, the p86 Ku gene product is essential for DSB repair and V(D)J recombination.
Continuity of the Perron Root
Creators: name: Meyer, Carl D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 1502 (Primary) 14F05, 14J26 (Secondary), "Perron-Frobenius Theory", "Nonnegative Matrices"

description: That the Perron root of a square nonnegative matrix A varies continuously with the entries in A is a corollary of theorems regarding continuity of eigenvalues or roots of polynomial equations, the proofs of which necessarily involve complex numbers. But since continuity of the Perron root is a question that is entirely in the field of real numbers, it seems reasonable that there should exist a development involving only real analysis. This article presents a simple and completely self-contained development that depends only on real numbers and first principles.
description: Received: 21 Feb 2014, Accepted: 9 Jun 2014, Published online: 03 Jul 2014, Linear and Multilinear Algebra, 2014
title: Electrochemical hydrogen permeation measurement during cyclic stress testing of a ferritic chromium steel
Creators: name: Vatter, J. M.
name: Jung, B.
name: Oechsner, M.
Publisher: name: Wiley-VCH
Year: 2024

description: In the present work, the hydrogen diffusion during cyclic stress testing in the ferritic chromium steel 1.4521 (X2CrMoTi18‐2) is investigated. Therefore, electrochemical hydrogen permeation measurements are carried out on a hollow cylinder geometry. Simultaneously an alternating stress is applied using a stress ratio of R=‐1. At low stress amplitudes, no influence on the diffusion behaviour of hydrogen is found. At a higher stress amplitude, close to the macroscopic yield strength, a delayed hydrogen permeation by a factor of two is observed. It is postulated that this observation is a result of the nucleation of new hydrogen traps during the measurement. Hydrogen content measurements using carrier gas hot extraction support this hypothesis.
MPEC 2023-U266 : 2023 UL9
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 UL9

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Defective G protein activation of the cAMP pathway in rat kidney during genetic hypertension.
Creators: name: Ruan, X.
name: Arendshorst, W. J.
name: Chatziantoniou, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The development of hypertension in the spontaneously hypertensive rat (SHR) is associated with renal dysfunction and vasoconstriction. The kidneys of young SHRs exhibit exaggerated reactivity to angiotensin II (Ang-II) and attenuated responses to vasodilators that normally activate the cAMP signal to buffer hormone-induced vasoconstriction. The present study investigates the mechanism(s) responsible for this abnormality in activation of the cAMP second-messenger pathway in hypertensive animals. Renal vascular reactivity was assessed in 7-week-old anesthetized SHRs and normotensive Wistar-Kyoto rats. The animals were pretreated with indomethacin to block prostanoid production throughout an experiment. Ang-II was injected into the renal artery either alone or mixed with the vasodilator fenoldopam, a dopamine-receptor agonist. These two opposing vasoactive agents were administered before and during intrarenal infusion of NaF or cholera toxin, two activators of G proteins that stimulate cAMP production. The results show that Ang-II reduced renal blood flow by 45% in both strains. In Wistar-Kyoto rats, fenoldopam reduced the Ang-II-induced decrease in renal blood flow from -45% to -30%. This protective effect of fenoldopam was increased further during infusion of NaF or cholera toxin (-18% or -19% decrease in renal blood flow). In SHRs, fenoldopam failed to attenuate Ang II-mediated vasoconstriction (-45% vs. -44%). In contrast, fenoldopam effectively blunted the Ang-II-induced vasoconstriction when it was given concurrently with NaF or cholera toxin (-27 or -31% decrease in renal blood flow). These findings provide evidence for defective interaction between receptor coupling and activation of guanine nucleotide stimulatory factor proteins in the renal microcirculation of 7-week-old SHRs. Such a deficiency could play an important role in renal dysfunction associated with the development of genetic hypertension.
title: Exploring the Impact of Preprints in Neuroscience: Insights from Lucia Melloni
Creators: name: Chen, Xiaoli
Publisher: name: DataCite
Year: 2023

description: As preparation to the submission of the first preprint from the research study in the FAIR Workflows project, I spoke with Professor Lucia Melloni, the co-director of the project and principal investigator at the MPIEA, to discuss the influence and evolution of preprints in neuroscience research. Our conversation provided an in-depth look at her experiences and views on this shift in scientific dissemination.
More ferroelectrics discovered by switching spectroscopy piezoresponse force microscopy?
Creators: name: Miao, Hongchen
name: Tan, Chi
name: Zhou, Xilong
name: Wei, Xiaoyong
name: Li, Faxin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The local hysteresis loop obtained by switching spectroscopy piezoresponse force microscopy (SS-PFM) is usually regarded as a typical signature of ferroelectric switching. However, such hysteresis loops were also observed in a broad variety of non-ferroelectric materials in the past several years, which casts doubts on the viewpoint that the local hysteresis loops in SS-PFM originate from ferroelectricity. Therefore, it is crucial to explore the mechanism of local hysteresis loops obtained in SS-PFM testing. Here we proposed that non-ferroelectric materials can also exhibit amplitude butterfly loops and phase hysteresis loops in SS-PFM testing due to the Maxwell force as long as the material can show macroscopic D-E hysteresis loops under cyclic electric field loading, no matter what the inherent physical mechanism is. To verify our viewpoint, both the macroscopic D-E and microscopic SS-PFM testing are conducted on a soda-lime glass and a non-ferroelectric dielectric material Ba0.4Sr0.6TiO3. Results show that both materials can exhibit D-E hysteresis loops and SS-PFM phase hysteresis loops, which can well support our viewpoint.
description: 12 pages,4 figures
Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation.
Creators: name: Vos, J. M.
name: Svoboda, D. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: We have constructed simian virus 40 minireplicons containing uniquely placed cis,syn-thymine dimers (T <> T) for the analysis of leading- and lagging-strand bypass replication. Assaying for replication in a human cell-free extract through the analysis of full-size labeled product molecules and restriction fragments spanning the T <> T site resulted in the following findings: (i) The primary site of synthesis blockage with T <> T in either the leading or lagging strand was one nucleotide before the lesion. (ii) Replicative bypass of T <> T was detected in both leading and lagging strands. The efficiency of synthesis past T <> T was 22% for leading-strand T <> T and 13% for lagging-strand T <> T. (iii) The lagging-strand T <> T resulted in blocked retrograde synthesis with the replication fork proceeding past the lesion, resulting in daughter molecules containing small gaps (form II' DNA). (iv) With T <> T in the leading-strand template, both the leading and lagging strands were blocked, representing a stalled replication fork. Uncoupling of the concerted synthesis of the two strands of the replication fork was observed, resulting in preferential elongation of the undamaged lagging strand. These data support a model of selective reinitiation downstream from the lesion on lagging strands due to Okazaki synthesis, with no reinitiation close to the damage site on leading strands [Meneghini, R. & Hanawalt, P.C. (1976) Biochim. Biophys. Acta 425, 428-437].