cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characteristics of Recent Column-Compound Extremes in the Global Ocean
Creators: name: Wong, Joel
name: Gruber, Nicolas
name: Münnich, Matthias
Publisher: name: ETH Zurich
Year: 2023

description: Marine extreme events can be detrimental to organisms and ecosystems across the global ocean. Marine heatwaves (MHW), ocean acidity extremes (OAX) and low oxygen extremes (LOX) occur everywhere, superimposed on the already changing trends of temperature, pH, and oxygen. When such extremes concurrently occur in the vertical column, the habitable space for marine organisms can be severely reduced. We use daily output from a hindcast simulation with the Community Earth System Model coupled with Biological Elemental Cycling (CESM-BEC) for the period 1961-2020 to characterise such compound extremes. Extreme conditions are identified on a moving baseline with the 95th or 5th percentile, and an additional absolute threshold of 150 μM for low oxygen conditions. To investigate compound events in the vertical dimension, at least 50 m out of the top 300 m is required to be extreme with respect to each stressor. Such an event is termed a column-compound extreme event (CCX). On average, 1% of the global ocean volume is occupied by CCXs and up to 5% at maximum. On a fixed baseline these values increase to 8% and 27% respectively. CCXs decrease habitable space by up to 75% and have high intensity index of more than 2 in many regions around the globe. El Niño-Southern Oscillation events are found to be strongly associated with CCXs in the tropical and subtropical Pacific, but also other ocean basins through teleconnections. The global volume of CCXs is expected in increase in the future, exacerbating impacts and reducing habitable space of marine organisms.
description: EGUsphere
Additional file 1: of Nutrient intakes and nutritional biomarkers in pregnant adolescents: a systematic review of studies in developed countries
Creators: name: Marvin-Dowle, Katie
name: Burley, Victoria
name: Hora Soltani
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Computational Biology

description: Table S1. Characteristics of Excluded Studies. Table S2. Pooled, Weighted Mean Nutrient Intakes Expressed as Percentages of Dietary Reference Values by Stage of Pregnancy. Table S3. Pooled, Weighted Mean Nutrient Intakes Expressed as Percentages of Dietary Reference Values by Study Country of Origin. Table S4. Pooled, Weighted Mean Biological Markers of Nutritional Status by Stage of Pregnancy. Table S5. Pooled, Weighted Mean Biological Markers of Nutritional Status by Study Country of Origin. (DOCX 57Â kb)
Validation of a Framework for Bias Identification and Mitigation in Algorithmic Systems
Creators: name: Klein, Eduard
Publisher: name: IARIA
Year: 2022
Subjects: Bias Framework
Artificial intelligence
Algorithmic system
Validation.

description: Bias in algorithmic systems is a major cause of unfair and discriminatory decisions in the use of such systems. Cognitive bias is very likely to be reflected in algorithmic systems as humankind aims to map Human Intelligence (HI) to Artificial Intelligence (AI). We conducted an extensive literature review on the identification and mitigation of bias, leading to precise measures for project teams building AI systems. Moreover, we developed an awareness-raising framework for use as a guideline for project teams, addressing AI responsibility, AI fairness, and AI safety. The framework proposes measures in the form of checklists to identify and mitigate bias in algorithmic systems considering all steps during system design, implementation, and application. We validated the framework successfully in the context of industrial AI projects.
The fragile nature of road transportation systems
Creators: name: Sun, Linghang
name: Zhang, Yifan
name: Axenie, Cristian
name: Grossi, Margherita
name: Kouvelas, Anastasios
name: Makridis, Michail
Publisher: name: ETH Zurich
Year: 2024
Subjects: (Anti-)fragility
Road transportation systems
Macroscopic fundamental diagram
Model stochasticity

description: Major cities worldwide experience problems with the performance of their road transportation systems. The continuous increase in traffic demand presents a substantial challenge to the optimal operation of urban road networks and the efficiency of traffic control strategies. Although robust and resilient transportation systems have been extensively researched over the past decades, their performance under an ever-growing traffic demand can still be questionable. The operation of transportation systems is widely believed to display fragile property, i.e., the loss in performance increases exponentially with the linearly increasing magnitude of disruptions, which undermines their continuous operation. The risk engineering community is now embracing the novel concept of (anti-)fragility, which enables systems to learn from historical disruptions and exhibit improved performance as disruption levels reach unprecedented magnitudes. In this study, we demonstrate the fragile nature of road transportation systems when faced with either demand or supply disruptions. First, we conducted a rigorous mathematical analysis to theoretically establish the fragile nature of the systems. Subsequently, by taking into account real-world stochasticity, we implemented a numerical simulation with realistic network data to bridge the gap between the theoretical proof and the real-world operations, to study the impact of uncertainty on the fragile property of the systems. This work aims to help researchers better comprehend the necessity to explicitly consider antifragile design toward the application of future traffic control strategies, coping with constantly growing traffic demand and subsequent traffic accidents.
description: arXiv
Distantasca Dworakowska
Creators: name: Liu, Yang
name: Fletcher, Murray J.
name: Zhang, Ya-Lin
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Distantasca

description: Distantasca Dworakowska, reinstated genus
Distantasca Dworakowska 1972: 25
Empoasca (Distantasca Dworakowska), Dworakowska & Viraktamath 1975: 521–530 Type species: Empoasca terminalis Distant (1918).
Diagnosis. Body green or yellowish. Anterior margin of vertex roundly produced. Pronotum broad, with anterior margin roundly produced and posterior margin nearly straight, middle length longer than that of vertex. Forewing rounded apically, apical cells occupying less than third its length, second apical cell long, apically slightly broader, third apical cell not stalked and usually rectangular, RP, MP1 from r cell and MP2 +CuA1 from m cell, c and r cells narrower than m and cua cells, distance between cu and m apical veins long; 1st and 2nd apical cells nearly equal to each other. Hind wing with CuA unbranched, apical cell long and broad. Pygofer side short, pygofer appendage surpassing the tip of pygofer side. Anal tube appendages well developed, smoothly tapered towards apex, large and smooth with a big subapical tooth or short and arcuate. Subgenital plate, in lateral view, curved gradually caudodorsad apically, not expanded apically, with numerous macrosetae and fine setae somewhat irregular; group A with 3–5 long stout setae subbasally; group B with 12–15 short microsetae on apical half, group C double near base with single row of macrosetae distally extended to apex.
Note. We recognize Distantasca as a valid genus because, although it resembles Empoasca in external morphology, it differs in having the male subgenital plate with group D setae elongate and divided into distinct basal and distal groups and the connective with the stem strongly constricted and narrow.
description: Published as part of Liu, Yang, Fletcher, Murray J. & Zhang, Ya-Lin, 2014, Reinstatement of Distantasca Dworakowska (Hemiptera: Cicadellidae: Typhlocybinae: Empoascini) as a valid genus with new species and new combinations in Zootaxa 3869 (1), DOI: 10.11646/zootaxa.3869.1.9, http://zenodo.org/record/231317
The Perceptions of People with Dementia and Key Stakeholders Regarding the Use and Impact of the Social Robot MARIO
Creators: name: Casey, Dympna
name: Barrett, Eva
name: Kovacic, Tanja
name: Sancarlo, Daniele
name: Ricciardi, Francesco
name: Murphy, Kathy
name: Koumpis, Adamantios
name: Santorelli, Adam
name: Gallagher, Niamh
name: Whelan, Sally
Publisher: name: MDPI
Year: 2020
Subjects: dementia
Alzheimer’s
older adults
social robots
companion robots
MARIO
qualitative research
quality of care
long-term care

description: People with dementia often experience loneliness and social isolation. This can result in increased cognitive decline which, in turn, has a negative impact on quality of life. This paper explores the use of the social robot, MARIO, with older people living with dementia as a way of addressing these issues. A descriptive qualitative study was conducted to explore the perceptions and experiences of the use and impact of MARIO. The research took place in the UK, Italy and Ireland. Semi-structured interviews were held in each location with people with dementia (n = 38), relatives/carers (n = 28), formal carers (n = 28) and managers (n = 13). The data was analyzed using qualitative content analysis. The findings revealed that despite challenges in relation to voice recognition and the practicalities of conducting research involving robots in real-life settings, most participants were positive about MARIO. Through the robot’s user-led design and personalized applications, MARIO provided a point of interest, social activities, and cognitive engagement increased. However, some formal carers and managers voiced concern that robots might replace care staff.
Additional file 3: Table S1. of Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes
Creators: name: Takeuchi, Ryoko
name: Tada, Mari
name: Shiga, Atsushi
name: Toyoshima, Yasuko
name: Konno, Takuya
name: Sato, Tomoe
name: Nozaki, Hiroaki
name: Kato, Taisuke
name: Horie, Masao
name: Shimizu, Hiroshi
name: Takebayashi, Hirohide
name: Onodera, Osamu
name: Masatoyo Nishizawa
name: Kakita, Akiyoshi
name: Takahashi, Hitoshi
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy

description: Supplementary results on the neuropathological stages of Alzheimerâ  s disease-associated changes. (DOC 38Â kb)
The potential of a weight detection system for forwarders using an artificial neural network
Creators: name: Geiger, Chris
name: Greff, Daniel
name: Geimer, Marcus
name: Starke, Michael
name: Ziesak, Martin
Publisher: name: Fundación Conde del Vallede Salazar
Year: 2018
Subjects: forest management
process management
crane scale
weight detection
neural networks
Forwarder2020

description: To manage forest processes, information about the amount of timber that passed through different processing steps within the timber supply chain is essential. This information can be used both to keep the overview of the amount of timber already produced for initiating further activities and to clearaccrued operation expenses promptly. When felling operations have been supported by or carried outexclusively through manual working steps, information sources like harvester protocols are either not available or lack sufficient accuracy for their proper use. To solve this problem in cut-to-length logging, a weight-detection system can be integrated into the loading process of the logs as single stems or stem bundles. This system can be used for estimating the timber volume moved, thus closing the information gap without further interactional effort. Unlike common crane scales, which are not available for every type of machine, the method presented here for a weight-detection system is universally applicable in modern crane types. In the first step of the development stage, loading processes during the work task of the forwarder are detected. Using an artificial neural network and data provided by the sensor set of a modern crane, the weight of the load in the grapple can be estimated based on the position of the grapple and the hydraulic pressure of the boom cylinder during these loading processes. The accuracy error of only 10% of the volume moved after initial training of the neural network demonstrates the potential of this system. By obtaining more training data through further measurements, an accuracy error of less than 4% is expected. For decision making within the forwarding process, this technique can therefore be a reasonable solution for short-term and extensive implementation of the smart forwarding processes that are currently being established in the Forwarder2020 project.
Numerical Piecewise Potential Vorticity Inversion - A user guide for real-case experiments
Creators: name: Sprenger, Michael
Publisher: name: ETH Zurich
Year: 2007
Subjects: potential vorticity, inversion, atmospheric dynamics
info:eu-repo/classification/ddc/004
Data processing, computer science

description: Potential vorticity (PV) is a key quantity in atmospheric dynamics. Its value is based upon several points: (a) PV is conserved in purely adiabatic flows, i.e. if radiative and condensational heating and other diabatic processes can be neglected; (b) under suitable balance conditions the specification of PV in the interior of a domain and with boundary values for potential temperature completely determines the flow field, in particular horizontal wind and temperature can be derived; (c) in many respects the atmosphere can be partitioned into several distinct PV features, which then interact and allow the dynamics to be interpreted as the interaction of these PV elements. Points (b) and (c) are known as the invertibility and partitioning principle, respectively.

In this thesis, a program package is presented which allows to isolate PV elements and then to study their impact on the atmospheric flow field and on the temperature distribution. Technically, this is done with a so-called PV inversion, which in turn comprises several different steps, as for example transformation into suitable co-ordinate systems and numerical solution of a poisson equation. With PV inversion, two major problems arise: Firstly, a suitable balance condition must be formulated, secondly the inversion problem for Ertel’s PV is nonlinear, and therefore poses a significant challenge. The program presented in this thesis is based upon the so-called quasi-geostrophic balance condition. More specifically, the linear quasi-geostrophic PV equation is solved. Since quasi-geostrophic and Ertel’s PV do not exactly coincide, an iterative technique is adopted to approach the nonlinear Ertel-PV inversion by means of successively quasi-geostrophic inversions.

The aim of this work is to present an in-depth discussion of all steps which are needed for a PV inversion. Special focus was given to a clear and user-friendly program package, where all steps are well documented and hence are attractive for further development. In this respect, the complete inversion is controlled by one single Linux Shell script. The new user needs only to adjust some few paths in this script. The main parameters for the inversion itself are specified in a separate parameter file.
Additional file 1: of Convergent validity of the interRAI-HC for societal costs estimates in comparison with the RUD Lite instrument in community dwelling older adults
Creators: name: Lier, Lisanne Van
name: Roest, Henriëtte Van Der
name: Hout, Hein Van
name: Eenoo, Liza Van
name: Declercq, Anja
name: Vjenka Garms-Homolová
name: Onder, Graziano
name: Finne-Soveri, Harriet
name: Jónsson, Pálmi
name: Hertogh, Cees
name: Judith. Bosmans
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Plant Biology

description: Country specific resource utilisation. Resource utilisation estimates over a three month period assessed with the RUD Lite and InterRAI-HC by country (DOCX 44 kb)
Distantasca smithi Fletcher & Donaldson 1992, n. comb.
Creators: name: Liu, Yang
name: Fletcher, Murray J.
name: Zhang, Ya-Lin
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Distantasca
Distantasca smithi

description: Distantasca smithi (Fletcher & Donaldson, 1992), n. comb.
(Figs 1–6, 25, 28, 31)
Empoasca (Empoasca) smithi Fletcher & Donaldson, 1992: 183 –186
Type materials. Australia: holotype (examined): ♂, Queensland: Mundubbera, 1.iii.1989, coll. D. Smith, ex Citrus (ASCU); paratypes (examined): 3 ♀♀, same data as holotype
Distribution. Australia (Queensland).
Note. The anal tube appendages of Distantasca smithi are well developed and the long and narrow subgenital plates have macrosetae reaching the tip of the plate (Figs 1–2). The setae of group group D are divided into two bands one near the mid-length of the plate and one just before the apex and are elongate and hairlike setae (Fig 1). This is a diagnostic feature of Distantasca and consequently this species is transferred from Empoasca (Empoasca) into the genus Distantasca. The narrow, constricted stem of the connective is also characteristic of Distantasca although it is narrower in D. smithi than in other known members of the genus.
description: Published as part of Liu, Yang, Fletcher, Murray J. & Zhang, Ya-Lin, 2014, Reinstatement of Distantasca Dworakowska (Hemiptera: Cicadellidae: Typhlocybinae: Empoascini) as a valid genus with new species and new combinations in Zootaxa 3869 (1), DOI: 10.11646/zootaxa.3869.1.9, http://zenodo.org/record/231317
MOESM2 of A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations
Creators: name: Gonzรกlez-Ramos, Daniel
name: Vries, Arthur Gorter De
name: Grijseels, Sietske
name: Berkum, Margo
name: Swinnen, Steve
name: Broek, Marcel
name: Nevoigt, Elke
name: Jean-Marc Daran
name: Pronk, Jack
name: Maris, Antonius
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2. Primers used to sequence the SNPs.
Safe start at home: what parents of newborns need after early discharge from hospital – a focus group study
Creators: name: Kurth, Elisabeth
name: Krähenbühl, Katrin
name: Eicher, Manuela
name: Rodmann, Susanne
name: Fölmli, Luzia
name: Conzelmann, Cornelia
name: Zemp, Elisabeth
Publisher: name: Springer
Year: 2016
Subjects: Postnatal care
Patient satisfaction
Interprofessional collaboration
Length of hospital stay
Health visiting
Midwifery

description: Background: The length of postpartum hospital stay is decreasing internationally. Earlier hospital discharge of mothers and newborns decreases postnatal care or transfers it to the outpatient setting. This study aimed to investigate the experiences of new parents and examine their views on care following early hospital discharge. Methods: Six focus group discussions with new parents (n = 24) were conducted. A stratified sampling scheme of German and Turkish-speaking groups was employed. A ‘playful design’ method was used to facilitate participants communication wherein they used blocks and figurines to visualize their perspectives on care models The visualized constructions of care models were photographed and discussions were audio-recorded and transcribed verbatim. Text and visual data was thematically analyzed by a multi-professional group and findings were validated by the focus group participants. Results: Following discharge, mothers reported feeling physically strained during recuperating from birth and initiating breastfeeding. The combined requirements of infant and self-care needs resulted in a significant need for practical and medical support. Families reported challenges in accessing postnatal care services and lacking inter-professional coordination. The visualized models of ideal care comprised access to a package of postnatal care including monitoring, treating and caring for the health of the mother and newborn. This included home visits from qualified midwives, access to a 24-h helpline, and domestic support for household tasks. Participants suggested that improving inter-professional networks, implementing supervisors or a centralized coordinating center could help to remedy the current fragmented care. Conclusions: After hospital discharge, new parents need practical support, monitoring and care. Such support is important for the health and wellbeing of the mother and child. Integrated care services including professional home visits and a 24-hour help line may help meet the needs of new families.
Asynchronous ECG time sampling: Saving bits with Golomb-Rice encoding
Creators: name: Marisa, T.
name: Niederhauser, Thomas
name: Haeberlin, A.
name: Goette, J.
name: Jacomet, Marcel
name: Vogel, R.
Publisher: name: Computing in Cardiology
Year: 2012
Subjects: Electrocardiography
Educational institutions
Heart beat
signal resolution
Surface waves
Encoding
Memory management

description: We present a technique for online compression of ECG signals using the Golomb-Rice encoding algorithm. This is facilitated by a novel time encoding asynchronous analog-to-digital converter targeted for low-power, implantable, long-term bio-medical sensing applications. In contrast to capturing the actual signal (voltage) values the asynchronous time encoder captures and encodes the time information at which predefined changes occur in the signal thereby minimizing the sensor's energy use and the number of bits we store to represent the information by not capturing unnecessary samples. The time encoder transforms the ECG signal data to pure time information that has a geometric distribution such that the Golomb-Rice encoding algorithm can be used to further compress the data. An overall online compression rate of about 6 times is achievable without the usual computations associated with most compression methods.
Deep learning-based crop health enhancement through early disease prediction
Creators: name: Yakkala, Venkata Santhosh
name: Nusimala, Krishna Vamsi
name: Gayathri, Badisa
name: Kanamarlapudi, Sriya
name: Aravinth, S. S.
name: Salau, Ayodeji Olalekan
name: Srithar, S.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology

description: Manual disease detection methods currently in use are laborious, time-intensive, and heavily reliant on specialized knowledge. The urgent need to address these challenges motivates this study. The primary goal of this research is to develop a model capable of accurately distinguishing between healthy and diseased crop leaves. Additionally, the model aims to identify specific diseases affecting the crops if they are found to be diseased. Leveraging the power of machine learning algorithms, particularly Convolutional Neural Networks (CNNs) and ResNet-9 architecture, this research seeks to transform the process of detecting plant diseases. It focuses on analyzing diverse morphological features such as color, intensity, and dimensions in plant leaves to enable quick and accurate classification. By introducing AI-driven systems into agricultural practices, this study aims to revolutionize disease identification, prediction, and management. The overarching objective is to minimize crop losses and enhance agricultural productivity. In addition to highlighting the significance of machine learning techniques such as ResNet-9, this study emphasizes the importance of environmentally friendly biological control methods for regulating pests and diseases in agricultural settings. The adoption of Convolutional Neural Networks, specifically the ResNet-9 architecture, signifies a significant advancement in predicting plant diseases. This approach holds the promise of vastly improving the accuracy and efficiency of disease forecasting within the agricultural domain.
Determination of Antitumor Active Ingredients in Agarwood Essential Oil by Gas Chromatography-Mass Spectrometry (GC-MS) and Grey Relational Analysis
Creators: name: Zhang, Yanlin
name: Wu, Shenghong
name: Zhang, Bingzhi
name: Zhou, Xin
name: Zhou, Weiping
name: Zhang, Weimin
name: Gao, Xiaoxia
name: Chen, Xiaoying
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine

description: Agarwood essential oil (AEO) holds significant medicinal and economic value. While its antitumor activity is reported in the literature, the active ingredients remain unexplored. In this study, the chemical composition of AEO extracted by steam distillation (SD) and fungal fermentation-assisted SD (FFSD) was evaluated by gas chromatography-mass spectrometry (GC-MS). The antitumor activity was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Subsequently, the key active ingredients and targets of antitumor activity were evaluated using grey relational analysis and network pharmacology. The relative content of active ingredients in the AEOs extracted from different Aquilaria trees was compared. GC-MS tentatively identified 32 compounds, primarily sesquiterpenoids and aromatic compounds. Eight components with relative content differences were screened using orthogonal partial least squares-discriminant analysis (OPLS-DA), indicating that α-costal, guaiol, β-santalol may play important roles in the antitumor activity. Both SD and FFSD-extracted AEOs demonstrated the ability to inhibit the proliferation and survival of four cancer cell lines, with slightly stronger inhibitory effects observed in AEO extracted by SD. α-Costal, aristolone, 10-epi-γ-eudesmol, γ-eudesmol, agarospirol, hinesol, guaiol, β-santalol, and 6-isopropenyl-4,8a-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-2-ol were antitumor ingredients of AEO. The relative content of total active ingredients in agarwood (Aquilaria malaccensis) essential oil was higher, suggesting higher efficacy. This study confirmed the antitumor activity of AEO and identified its active ingredients. These findings provide a basis for further research on the antitumor mechanism of AEO.
Additional file 7: Figure S3. of Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations
Creators: name: Walsh, Alice
name: Whitaker, John
name: C. Huang
name: Cherkas, Yauheniya
name: Lamberth, Sarah
name: Brodmerkel, Carrie
name: Curran, Mark
name: Dobrin, Radu
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Genes associated with RA GWAS in T cell specific epigenomic datasets. Heatmap of genes associated with RA GWAS SNPs overlapping enhancers in the shown T cell datasets. PB, peripheral blood. Two T cell epigenomes uniquely identify genes that might be explained by unique aspects of the selection markers and (when carried out) in vitro differentiation protocols: (1) “Primary T cells from PB” was the only T cell sample to use CD3+ as a selection marker; and (2) “Primary T helper cells PMA-I stimulated” was the only sample that used Magnetic-activated cell sorting (MACS) [5]. The differences between the two “Primary T helper memory cells from PB” samples might be explained by their different differentiation protocols (number 1 uniquely used CD25M and CD45RO as selection markers) or by the differing donors of origin [5]. (PDF 7665 kb)
Visual Determination of Copper (II) Using a Biomass Sourced Carbon Quantum Dot (CQD) Ratiometric Fluorescent Probe
Creators: name: He, Wen
name: Lim, Soh Fong
name: Baini, Rubiyah
name: Qu, Yanping
name: Li, Xiujuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: Accurate detection of copper ions is crucial since it is an essential trace element. Carbon quantum dots (CQDs) were prepared from apricot leaves using a hydrothermal method. These CQDs, which generated a reference signal, were combined with glutathione-bound gold nanoclusters (GSH-AuNCs) synthesized by the reduction of chloroauric acid to form a ratiometric fluorescent probe. The probe exhibited fluorescence emission at 450 nm and 568 nm. The determination of Cu(II) was performed through visual analysis of the color change and the intensity ratio (I450/I568) of the emission peaks. Orange fluorescent GSH-AuNCs responded to Cu(II) with fluorescence, and the blue fluorescent CQDs were chemically inert. The probes changed color from pink to purple to blue in response to different concentrations of Cu(II). The linear range of the fluorescence probe for Cu(II) was 0 to 120 µmol/L, and the limit of detection (LOD) was 0.65 µmol/L. This study has demonstrated that the probe provided good selectivity for detecting Cu(II) in water and has potential practical application.
Additional file 1: of Genome sequences of Knoxdaviesia capensis and K. proteae (Fungi: Ascomycota) from Protea trees in South Africa
Creators: name: Aylward, Janneke
name: Steenkamp, Emma
name: LĂŠanne Dreyer
name: Francois Roets
name: Wingfield, Brenda
name: Wingfield, Michael
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Table S1. Associated MIGS record for K. capensis. (DOC 75 kb)
Additional file 2: of Convergent validity of the interRAI-HC for societal costs estimates in comparison with the RUD Lite instrument in community dwelling older adults
Creators: name: Lier, Lisanne Van
name: Roest, Henriëtte Van Der
name: Hout, Hein Van
name: Eenoo, Liza Van
name: Declercq, Anja
name: Vjenka Garms-Homolová
name: Onder, Graziano
name: Finne-Soveri, Harriet
name: Jónsson, Pálmi
name: Hertogh, Cees
name: Judith. Bosmans
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Country specific cost of care estimates. Comparison of cost of care estimates (€) over a three month period between care utilisation assessed with the RUD Lite and interRAI-HC by country. (DOCX 28 kb)
Managing information overload in virtual teams: Effects of a structured online team adaptation on cognition and performance
Creators: name: Ellwart, Thomas
name: Happ, Christian
name: Gurtner, Andrea
name: Rack, Oliver
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Information overload
Team adaptation
Team mental models
Virtual teams

description: Information overload (IO) indicates the exchange of too much low-quality information in virtual teams. When being overloaded with information, teams need to adapt and to change communication behaviour. This study introduces and tests a structured online team adaptation (STROTA) procedure that enables virtual teams to reduce IO by improving their team mental model quality. STROTA, built from team adaptation models, is a moderated intervention consisting of three stages: (1) individual situation awareness, (2) team situation awareness, and (3) plan formulation. STROTA was tested in the context of an experimental problem-solving task. Participants (N = 363) worked in virtual teams of three and were randomly assigned to one of four experimental conditions: no STROTA, incomplete STROTA (step 1, steps 1–2), and complete STROTA (steps 1–2–3). We found teams that followed a complete STROTA procedure experienced lessened IO over time. Teams with complete STROTA showed the largest development of TMM immediately after STROTA. Finally, multilevel mediation analyses showed that TMM are mediators that explain the influence of STROTA on IO.
Therapeutic Monitoring of Flutamide Using Aggregated Surface Enhanced Raman Spectroscopy (SERS) Substrates
Creators: name: A., Esther Jebakumari K.
name: K., Murugasenapathi N.
name: R., Udit Millenn
name: El-Kemary, Maged
name: Palanisamy, Tamilarasan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Physical Sciences not elsewhere classified
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: It is essential to monitor the blood level of flutamide (FLT) during prostate cancer treatment since the abnormal renal elimination due to pathophysiological factors hinders attaining steady-state drug concentration. This study reports a systematic investigation of aggregation of silver nanoparticles (AgNPs) based on Hofmeister effect and eventual change in surface-enhanced Raman spectroscopy (SERS) enhancement for the determination of FLT. Among the aggregants, MgSO4 showed the maximum enhancement. The concentration of MgSO4, pH, and duration of aggregation were optimized for FLT detection. The aggregated AgNPs (a-AgNPs) SERS substrate enhanced the Raman signal of FLT by up to five-orders of magnitude under optimized conditions. The developed technique was able to determine FLT from 0.25 × 10−3 μM to 250 μM with a limit of detection (LoD) of 1 pM. The application of the SERS substrate in practical analysis has been demonstrated using FLT-spiked human serum from 0 nM to 1000 nM with a detection limit of 0.3 nM. The reported Hofmeister series of AgNPs aggregation will assist in the development of SERS substrates for other analytes.
Recipe analysis, reconstruction and re-enactment: historical technical source on the cleaning of easel Paintings
Creators: name: Devesa, Joana
name: Carlyle, Leslie
name: Stols-Witlox, Maartje
name: Boon, Jaap J.
name: Fernando, Ana Luisa
name: Zumbühl, Stefan
name: De Sá, Susana França
Publisher: name: ICOM-CC Publications
Year: 2022

description: Analysis of over 180 historical documentary sources from 1600 to 1900 covering the cleaning of oil paintings established that the use of alkalis was mentioned in over 50% of references to aqueous cleaning. Alkalis could be employed as a paste with wood ashes and water or in the form of lye. Historical alkali cleaning recipes based on wood ashes were reconstructed and characterised using titration and in- ductively coupled plasma-atomic emission spectroscopy (ICP-AES). Results indicate that pH depends on the wood-ash source, the age of both the ashes and the lye, as well as on the proportion of ash to water. Reconstructions of lye solutions and wood-ash pastes were applied to naturally aged model oil paints and oil paintings. Their visual impact was investigated using high resolution imaging, and chemical changes were studied with infrared spectroscopy in attenuated total reflection (ATR-FTIR) and focal-plane array Fourier transform infrared spectroscopy (FTIR-FPA) as well as scanning electron microscopy equipped with energy-dispersive X-ray analysis (SEM-EDX). These latter investigations determined the presence of potassium within the upper layers of paint samples after exposure to wood ash lye. The potassium remained in the oil network after extensive water rinsing. This research adds information to our existing knowledge about historical cleaning methodologies and contributes to a better understanding of the current condition of paintings previously cleaned with alkalis.
MOESM4 of A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations
Creators: name: Gonzรกlez-Ramos, Daniel
name: Vries, Arthur Gorter De
name: Grijseels, Sietske
name: Berkum, Margo
name: Swinnen, Steve
name: Broek, Marcel
name: Nevoigt, Elke
name: Jean-Marc Daran
name: Pronk, Jack
name: Maris, Antonius
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 4. Primers, cassettes and SHR used for direct replacement approach.
[Prometeo presenta ''Propiedad clausurada'' Comedia en un acto de Tennessee Williams]
Creators: name: Eduardo, Manet
name: Manet, Eduardo
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Théâtre
''Propiedad clausurada''

description: Représentation par le Théâtre Prometeo de la pièce ''Propiedad clausurada'' de Tennessee Williams, mise en scène par Eduardo Manet, au Parc Central de La Havane. La seconde pièce représentée est : ''Entremés del mancebo que casó con mujer brava'', pièce en un acte de Alejandro Casona.
description: Función del Teatro Prometeo de la obra ''Propiedad clausurada'' de Tennessee Williams, dirigida por Eduardo Manet, en el Parque Central de La Habana. La segunda obra es: “Entremés del mancebo que casó con mujer brava”, obra en un acto de Alejandro Casona.
description: Notes : Traces de ruban adhésif à chaque coin du document.
description: Source: EM-C1-1-1950-01-06
description: Source: Localisation de la ressource : Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
Dasyurus viverrinus
Creators: name: Jackson, Stephen M.
name: Jansen, Justin J. F. J.
name: Baglione, Gabrielle
name: Callou, Cécile
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Dasyuromorphia
Dasyuridae
Dasyurus
Dasyurus viverrinus

description: Dasyurus guttatus Desmarest, 1804a
Dasyurus guttatus Desmarest, 1804a: 10.
COMMON NAME. — Eastern Quoll.
CURRENT NAME. — Dasyurus viverrinus (Shaw, 1800).
See Jackson & Groves (2015: 57).
COLLECTOR/S. — No data.
COLLECTION LOCALITY. — Australia (no precision).
COLLECTION DATE. — No data.
SPECIMEN NUMBER/S. — No specimen identified in MNHN collection. The illustrations above under the name Dasyurus maugei É. Geoffroy Saint-Hilaire, 1803 are also referable here.
ILLUSTRATIONS. — No data.
description: Published as part of Jackson, Stephen M., Jansen, Justin J. F. J., Baglione, Gabrielle & Callou, Cécile, 2021, Mammals collected and illustrated by the Baudin Expedition to Australia and Timor (1800 - 1804): A review of the current taxonomy of specimens in the Muséum national d'Histoire naturelle de Paris and the illustrations in the Muséum d'Histoire naturelle du Havre, pp. 387-548 in Zoosystema 43 (21) on page 399, DOI: 10.5252/zoosystema2021v43a21, http://zenodo.org/record/5142972
Diversité(s) au coeur des politiques et des pratiques : entre l’Europe et l’Afrique
Creators: name: Sy, Kalidou
name: Stalder, Pia
name: Veillette, Josianne
name: Gohard-Radenkovic, Aline
Publisher: name: Université Laval
Year: 2017
Subjects: diversités
discours
politiques
stratégies
pratiques
Afrique
Europe

description: La diversité relève d’un constat : les espèces humaines, animales, végétales sont de facto variées car elles ont dû se transformer et se diversifier à travers les âges face aux mutations de leur environnement. La diversité est la condition même de leur existence, de leur survie. L’objectif de ce numéro n’est donc pas de remettre en question cette diversité en recomposition constante mais plutôt d’en investiguer les représentations et les usages à travers les discours, les dispositifs et les pratiques mis en œuvre au nom de la diversité.
Innovation drift: the influence of digital artefacts on organizing for innovation
Creators: name: Hron, Michal
name: Obwegeser, Nikolaus
name: Müller, Sune Dueholm
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Digital innovation
digital artifacts
organizational structures
case study

description: The literature on digital innovation often relies on examples of radical, even paradigm-changing novelties. In order to develop such radical innovations, organizational separation of innovation efforts has been advocated by many as an effective strategy. We have conducted a longitudinal case study of a radical innovation project at a born-digital company. The company established a separate organization to develop radical innovation, but over time, the innovation drifted from radical to incremental. Even keeping the organization separate proved difficult. In explaining the events in the case study, we follow the argument that new theories of digital innovation can be developed with reference to the specific properties of digital artefacts. We outline how properties like editability and distributability may contribute to innovation drift, i.e., the proclivity of radical innovation ambitions to gradually drift towards more incremental realizations. Due to their nature, digital artefacts can diffuse through the organization and, thus, pose a challenge to the effectiveness of organizational separation as a strategy for innovation. With this work, we contribute to the literature on digital innovation by responding to calls for research on new theories of digital innovation and the demand for greater appreciation of digital materiality in organizing. We also challenge the prevailing view of digital innovations as radical and aim to open a debate on the possibility and considerations surrounding incremental digital innovations.
Patent landscape of small molecule inhibitors of METTL3 (2020-present)
Creators: name: Wu, Zhixing
name: Smith, Alexis R.
name: Qian, Zhijian
name: Zheng, Guangrong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Methyltransferase-like protein 3 (METTL3), in complex with METTL14, is the key ‘writer’ protein for RNA m6A methylation, accounting for almost all mRNA m6A modifications. Recent studies reveal that METTL3 is implicated in the development and progression of various types of cancers. Targeting METTL3 with small molecule inhibitors represents a promising therapeutic strategy for cancer. This review provides an overview of the patent literature covering METTL3 inhibitors. A literature search was conducted in SciFinder by using ‘METTL3 inhibitor’ as a keyword and was refined by narrowing the criteria to patents. Efforts to develop METTL3/METTL14 inhibitors have led to the advancement of the drug candidate STC-15 to clinical trials. Preclinical studies of STC-15 show promise in inhibiting tumor growth via direct anti-tumor effects and anti-cancer immune responses. The clinical trial outcomes of STC-15 will shape future METTL3/METTL14 inhibitor development. However, critical questions remain. The role of METTL3/METTL14 in m6A RNA methylation is essential for cellular activity, raising concerns about the potential adverse effects of targeting this complex. Furthermore, depending on the context, METTL3/METTL14 can function as a tumor suppressor. This underscores the need for a deeper understanding of the molecular mechanisms by which RNA modifications regulate cancer.
Additional file 1: Table S1. of Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
Creators: name: Vici, Patrizia
name: Ercolani, Cristiana
name: Benedetto, Anna Di
name: Pizzuti, Laura
name: Lauro, Luigi Di
name: Sperati, Francesca
name: Terrenato, Irene
name: Gamucci, Teresa
name: Natoli, Clara
name: Filippo, Franco Di
name: Botti, Claudio
name: Barba, Maddalena
name: Mottolese, Marcella
name: Maria, Ruggero De
name: Maugeri-SaccĂ, Marcello
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: 60506 Virology

description: Expression of TAZ and YAP in cancer cells, non-lymphocytic stromal cells, endothelial cells, and tumor-infiltrating lymphocytes. Subcellular localization of TAZ/YAP in tumors is also reported (Nâ  =â  61). (DOCX 13 kb)