cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pre-Clinical Development of a Recombinant, Replication-Competent Adenovirus Serotype 4 Vector Vaccine Expressing HIV-1 Envelope 1086 Clade C
Creators: name: LaBranche, Celia
name: Farness, Peggy
name: Montefiori, David C.
name: Parks, Robert
name: Avanzini, Jenny B.
name: Vang, Lo
name: Alexander, Jeff
name: Swanstrom, Ronald
name: Manayani, Darly J.
name: Ping, Li-Hua
name: Smith, Jonathan
name: Haynes, Barton F.
name: Mendy, Jason
name: Mayall, Tim
name: Liao, Hua-Xin
name: Ishioka, Glenn
name: Garduno, Fermin
name: Gurwith, Marc
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundThere is a well-acknowledged need for an effective AIDS vaccine that protects against HIV-1 infection or limits in vivo viral replication. The objective of these studies is to develop a replication-competent, vaccine vector based on the adenovirus serotype 4 (Ad4) virus expressing HIV-1 envelope (Env) 1086 clade C glycoprotein. Ad4 recombinant vectors expressing Env gp160 (Ad4Env160), Env gp140 (Ad4Env140), and Env gp120 (Ad4Env120) were evaluated.MethodsThe recombinant Ad4 vectors were generated with a full deletion of the E3 region of Ad4 to accommodate the env gene sequences. The vaccine candidates were assessed in vitro following infection of A549 cells for Env-specific protein expression and for posttranslational transport to the cell surface as monitored by the binding of broadly neutralizing antibodies (bNAbs). The capacity of the Ad4Env vaccines to induce humoral immunity was evaluated in rabbits for Env gp140 and V1V2-specific binding antibodies, and HIV-1 pseudovirus neutralization. Mice immunized with the Ad4Env160 vaccine were assessed for IFNγ T cell responses specific for overlapping Env peptide sets.ResultsRobust Env protein expression was confirmed by western blot analysis and recognition of cell surface Env gp160 by multiple bNAbs. Ad4Env vaccines induced humoral immune responses in rabbits that recognized Env 1086 gp140 and V1V2 polypeptide sequences derived from 1086 clade C, A244 clade AE, and gp70 V1V2 CASE A2 clade B fusion protein. The immune sera efficiently neutralized tier 1 clade C pseudovirus MW965.26 and neutralized the homologous and heterologous tier 2 pseudoviruses to a lesser extent. Env-specific T cell responses were also induced in mice following Ad4Env160 vector immunization.ConclusionsThe Ad4Env vaccine vectors express high levels of Env glycoprotein and induce both Env-specific humoral and cellular immunity thus supporting further development of this new Ad4 HIV-1 Env vaccine platform in Phase 1 clinical trials.
Determinación de hidrocarburos clorados en tejido adiposo subcutáneo de lobos marinos de California ( Zalophus californianus californianus) varados muertos a lo largo de la Bahía de Todos Santos, Baja California /
Creators: name: Toro Muñoz, Ligeia Del.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Química biológica||Animales||Mamíferos marinos.
subject: QP551 T67 2003

description: Con el fin de evaluar los niveles de contaminación por hidrocarburos clorados en el hábitat del lobo marino de California (Zalophus californianus californianus), se determinaron concentraciones de estos compuestos en muestras de tejido adiposo subcutáneo de 18 lobos marinos de California, varados muertos durante enero de 2000 a noviembre 2001, a lo largo de la Bahía de Todos Santos, Baja California.
Primary Cilia: The Chemical Antenna Regulating Human Adipose-Derived Stem Cell Osteogenesis
Creators: name: Banes, Albert J.
name: Qi, Jie
name: Bernacki, Susan H.
name: Rubenstein, Candace D.
name: Loboa, Elizabeth G.
name: Bodle, Josephine C.
name: Phillips, Michelle E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Adipose-derived stem cells (ASC) are multipotent stem cells that show great potential as a cell source for osteogenic tissue replacements and it is critical to understand the underlying mechanisms of lineage specification. Here we explore the role of primary cilia in human ASC (hASC) differentiation. This study focuses on the chemosensitivity of the primary cilium and the action of its associated proteins: polycystin-1 (PC1), polycystin-2 (PC2) and intraflagellar transport protein-88 (IFT88), in hASC osteogenesis. To elucidate cilia-mediated mechanisms of hASC differentiation, siRNA knockdown of PC1, PC2 and IFT88 was performed to disrupt cilia-associated protein function. Immunostaining of the primary cilium structure indicated phenotypic-dependent changes in cilia morphology. hASC cultured in osteogenic differentiation media yielded cilia of a more elongated conformation than those cultured in expansion media, indicating cilia-sensitivity to the chemical environment and a relationship between the cilium structure and phenotypic determination. Abrogation of PC1, PC2 and IFT88 effected changes in both hASC proliferation and differentiation activity, as measured through proliferative activity, expression of osteogenic gene markers, calcium accretion and endogenous alkaline phosphatase activity. Results indicated that IFT88 may be an early mediator of the hASC differentiation process with its knockdown increasing hASC proliferation and decreasing Runx2, alkaline phosphatase and BMP-2 mRNA expression. PC1 and PC2 knockdown affected later osteogenic gene and end-product expression. PC1 knockdown resulted in downregulation of alkaline phosphatase and osteocalcin gene expression, diminished calcium accretion and reduced alkaline phosphatase enzymatic activity. Taken together our results indicate that the structure of the primary cilium is intimately associated with the process of hASC osteogenic differentiation and that its associated proteins are critical players in this process. Elucidating the dynamic role of the primary cilium and its associated proteins will help advance the application of hASC in generating autologous tissue engineered therapies in critical defect bone injuries.
Science Case and Requirements for the MOSAIC Concept for a Multi-Object Spectrograph for the European Extremely Large Telescope
Creators: name: Evans, C. J.
name: Puech, M.
name: Barbuy, B.
name: Bonifacio, P.
name: Cuby, J. -G.
name: Guenther, E.
name: Hammer, F.
name: Jagourel, P.
name: Kaper, L.
name: Morris, S. L.
name: Afonso, J.
name: Amram, P.
name: Aussel, H.
name: Basden, A.
name: Bastian, N.
name: Battaglia, G.
name: Biller, B.
name: Bouché, N.
name: Caffau, E.
name: Charlot, S.
name: Clenet, Y.
name: Combes, F.
name: Conselice, C.
name: Contini, T.
name: Dalton, G.
name: Davies, B.
name: Disseau, K.
name: Dunlop, J.
name: Fiore, F.
name: Flores, H.
name: Fusco, T.
name: Gadotti, D.
name: Gallazzi, A.
name: Giallongo, E.
name: Gonçalves, T.
name: Gratadour, D.
name: Hill, V.
name: Huertas-Company, M.
name: Ibata, R.
name: Larsen, S.
name: Fèvre, O. Le
name: Lemasle, B.
name: Maraston, C.
name: Mei, S.
name: Mellier, Y.
name: Östlin, G.
name: Paumard, T.
name: Pello, R.
name: Pentericci, L.
name: Petitjean, P.
name: Roth, M.
name: Rouan, D.
name: Schaerer, D.
name: Telles, E.
name: Trager, S.
name: Welikala, N.
name: Zibetti, S.
name: Ziegler, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Over the past 18 months we have revisited the science requirements for a multi-object spectrograph (MOS) for the European Extremely Large Telescope (E-ELT). These efforts span the full range of E-ELT science and include input from a broad cross-section of astronomers across the ESO partner countries. In this contribution we summarise the key cases relating to studies of high-redshift galaxies, galaxy evolution, and stellar populations, with a more expansive presentation of a new case relating to detection of exoplanets in stellar clusters. A general requirement is the need for two observational modes to best exploit the large (>40 sq. arcmin) patrol field of the E-ELT. The first mode ('high multiplex') requires integrated-light (or coarsely resolved) optical/near-IR spectroscopy of >100 objects simultaneously. The second ('high definition'), enabled by wide-field adaptive optics, requires spatially-resolved, near-IR of >10 objects/sub-fields. Within the context of the conceptual study for an ELT-MOS called MOSAIC, we summarise the top-level requirements from each case and introduce the next steps in the design process.
description: 17 pages, to be published in Proc SPIE 9147: Ground-based & Airborne Instrumentation for Astronomy V
LAPOP Poll: The Venezuela 2016 AmericasBarometer Round
Creators: name: LAPOP-Vanderbilt
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Life satisfaction (1); problems faced by country (1); economic situation (2); attendance at various meetings (6); protest participation (5); level of conflict in country (3); military coup (2); governing without Legislature (1); crime victim (2); feeling safe in neighborhood (1); judicial system (3); political system (10); pride in nationality (1); National Electoral Institution (2); Armed Forces (1); trust in National Assembly (1); police (2); trust in local institutions (1); media (9); trust in Student Movements (1); building or renovating (2); political polarization (3); President Nicolás Maduro job performance (1); Congress job performance (1); public services (4); government handling of economic issues (2); democracy (5); government interest in citizens (1); understanding of political issues (1); people sharing political views (2); natural disasters (2); environment vs. economy (1); climate change (1); abortion (1); freedom of expression (9); rights of homosexuals (2); bribes (10); murders (5); death penalty (1); voting (8); 2018 presidential election (4); Chavistas (7); Opposition (8); influence of foreign countries (1); trust in foreign countries (4); food shortages (1); inflation (1); exhumed Liberator curse (1); good vs. evil in politics (1); hopelessness (1); did US agents kill Chavez (1); government assistance (2).
Production and Characterization of Novel Recombinant Adeno-Associated Virus Replicative-Form Genomes: A Eukaryotic Source of DNA for Gene Transfer
Creators: name: Yuan, Zhenhua
name: Beley, Cyriaque
name: Smith, Richard H.
name: Qiao, Chunping
name: Li, Lina
name: Garcia, Luis
name: Kotin, Robert M.
name: Yang, Yu
name: Li, Juan
name: Dimitriadis, Emilios K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Conventional non-viral gene transfer uses bacterial plasmid DNA containing antibiotic resistance genes, cis-acting bacterial sequence elements, and prokaryotic methylation patterns that may adversely affect transgene expression and vector stability in vivo. Here, we describe novel replicative forms of a eukaryotic vector DNA that consist solely of an expression cassette flanked by adeno-associated virus (AAV) inverted terminal repeats. Extensive structural analyses revealed that this AAV-derived vector DNA consists of linear, duplex molecules with covalently closed ends (termed closed-ended, linear duplex, or “CELiD”, DNA). CELiD vectors, produced in Sf9 insect cells, require AAV rep gene expression for amplification. Amounts of CELiD DNA produced from insect cell lines stably transfected with an ITR-flanked transgene exceeded 60 mg per 5×109 Sf9 cells, and 1–15 mg from a comparable number of parental Sf9 cells in which the transgene was introduced via recombinant baculovirus infection. In mice, systemically delivered CELiD DNA resulted in long-term, stable transgene expression in the liver. CELiD vectors represent a novel eukaryotic alternative to bacterial plasmid DNA.
National Election Pool Poll: 2016 Connecticut Democratic Primary Election Day Exit Poll
Creators: name: ABC News
name: Associated Press
name: CBS News
name: CNN
name: Fox News
name: National Election Pool (NEP)
name: NBC
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Candidate that would have better chance at defeating Donald Trump (1); Democratic presidential primary vote (1); candidate that would do better job handling gun policy (1); candidate that inspires you more about the future of country (1); most important issues facing country (1); next president qualities and characteristics (1); party identification (1); political ideology (1); whether campaign energized/divided the Democratic party (1); candidate qualities that matter most in deciding vote (1); when did you decide presidential primary vote (1); whether you would be satisfied/unsatisfied if candidate won nomination (2); whether Wall Street helps/hurts the economy (1).
QORINCHALAR FIBRILYATSIYASI KUZATILAYOTGAN BEMORLARDA DEFIBRILYATOR ISH SAMARADORLIGINI BAHOLASH.
Creators: name: Mamatov, B.Y.
name: Ergashev, X.M.
name: Nabiyev, N.I.
Publisher: name: Zenodo
Year: 2023

description: Barchaga ma'lumki, kasalliklarning oxirgi bosqichlarida yoki to'satdan yuzaga keladidan hayotga xavf soladigan xolatlarda reanimatsion yordamga muhtojlik seziladi. Bunday vaziyatlarda asosiy e'tibor yurak, o'pka va miya faoliyatini tiklashga qaratiladi. Bunday holatlarda qorinchalar fibrilyatsiya yoki asistoliya kuzatiladi. Qorinchalar fibrilyatsiyasini bartaraf qilish uchun hozirda defibrilyator apparatlaridan foydalaniladi.
Topological Phases in Oxide Heterostructures with Light and Heavy Transition Metal Ions
Creators: name: Fiete, Gregory A.
name: Rüegg, Andreas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Using a combination of density functional theory, tight-binding models, and Hartree-Fock theory, we predict topological phases with and without time-reversal symmetry breaking in oxide heterostructures. We consider both heterostructures containing light transition metal ions, and those containing heavy transition metal ions. We find the (111) growth direction naturally leads to favorable conditions for topological phases in both perovskite structures and pyrochlore structures. For the case of light transition metal elements, Hartree-Fock theory predicts the spin-orbit coupling is effectively enhanced by on-site multiple-orbital interactions and may drive the system through a topological phase transition, while heavy elements with intrinsically large spin-orbit coupling require much weaker, or even vanishing electron interactions to bring about a topological phase.
description: 6 pages, 6 figures. Submitted to conference proceedings
Profiles of Serum Cytokines in Acute Drug-Induced Liver Injury and Their Prognostic Significance
Creators: name: Saha, Dhanonjoy
name: Lee, William M.
name: Foureau, David M.
name: Steuerwald, Nury M.
name: Barnhart, Huiman
name: Parsons, Judith C.
name: Bell, Lauren N.
name: Zhou, Jie
name: Davern, Timothy
name: Norton, H. James
name: Gu, Jiezhun
name: Fontana, Robert J.
name: Watkins, Paul B.
name: Chalasani, Naga
name: Bonkovsky, Herbert L.
name: Stolz, Andrew
name: Talwalkar, Jayant
name: Serrano, Jose
name: Reddy, K. Rajender
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the United-States. The aim of the study was to describe serum immune profiles associated with acute DILI, to investigate whether there are profiles associated with clinical features or types of DILI and/or with prognosis, and to assess temporal changes in levels. Twenty-seven immune analytes were measured in the sera of 78 DILI subjects in the Drug-Induced Liver Injury Network (DILIN) and compared with 40 healthy controls. Immune analytes (14 cytokines, 7 chemokines and 6 growth factors) were measured by BioPlex multiplex ELISA at DILI onset and after 6 months. A modeling process utilizing immune principles was used to select a final set of variables among 27 immune analytes and several additional clinical lab values for prediction of early death (within 6 months of DILI onset). Nineteen of the 27 immune analytes were differentially expressed among healthy control, DILI onset and 6-month cohorts. Disparate patterns of immune responses, especially innate and adaptive cellular (mostly TH17) immunity were evident. Low values of four immune analytes (IL-9, IL-17, PDGF-bb and RANTES) and serum albumin are predictive of early death [PPV = 88% (95% CI, 65%-100%), NPV = 97% (95% CI, 93%-100%), accuracy = 96% (95% CI, 92%-100%)].
National Election Pool Poll: 2016 Michigan Democratic Primary Election Day Exit Poll
Creators: name: ABC News
name: Associated Press
name: CBS News
name: CNN
name: Fox News
name: National Election Pool (NEP)
name: NBC
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Hillary Clinton's views, policies, positions, and character (4); worried about the direction of nation's economy (1); US economic system favors wealthy/is fair to Americans (1); feelings about the way the federal government is working (1); most important issues facing country (1); Democratic presidential primary vote (1); desired qualities and characteristics for next president (2); party identification (1); political ideology (1); candidate qualities that matter most (1); race relations in country (1).
Schrödinger functional boundary conditions and improvement for N>3
Creators: name: Hietanen, Ari
name: Karavirta, Tuomas
name: Vilaseca, Pol
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The standard method to calculate non-perturbatively the evolution of the running coupling of a SU(N) gauge theory is based on the Schrödinger functional (SF). In this paper we construct a family of boundary fields for general values of N which enter the standard definition of the SF coupling. We provide spatial boundary conditions for fermions in several representations which reduce the condition number of the squared Dirac operator. In addition, we calculate the O(a) improvement coefficients for N>3 needed to remove boundary cutoff effects from the gauge action. After this, residual cutoff effects on the step scaling function are shown to be very small even when considering non-fundamental representations. We also calculate the ratio of Lambda parameters between the MS-bar and SF schemes.
description: 33 pages, 6 figures
Australian Public Opinion Poll # 45
Creators: name: Australian Public Opinion Polls
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Favor/oppose daylight saving (1); voting age (1); government vs. private ownership of coal mines (1); government vs. private ownership of gas companies (1); government vs. private ownership of trading banks (1); satisfaction with income tax reductions (2); marketing referendum (1); employment referendum (1); social services referendum (1); living in Australia (1); influenza attacks (1); voting in federal election (1); possibility of another world war (2).
Australian Public Opinion Poll # 68
Creators: name: Australian Public Opinion Polls
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Sunday afternoon football (1); shopping hours (4); work in a shop (1); rates of currency exchange (2); atomic energy (1); atom bomb (1); voting in federal election (5); influences of religion and politics (2); continuing operation of Trans-Australia Airlines (TAA) (1).
3-D Tracking of Nuclear Recoils in a Miniature Time Projection Chamber
Creators: name: Vahsen, S. E.
name: Hedges, M. T.
name: Jaegle, I.
name: Ross, S. J.
name: Seong, I. S.
name: Thorpe, T. N.
name: Yamaoka, J.
name: Kadyk, J. A.
name: Garcia-Sciveres, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The three-dimensional (3-D) reconstruction of nuclear recoils is of interest for directional detection of fast neutrons and for direction-sensitive searches for weakly interacting massive particles(WIMPs), which may constitute the Dark Matter of the universe. We demonstrate this capability with a miniature gas target Time Projection Chamber (TPC) where the drift charge is avalanche-multiplied with Gas Electron Multipliers (GEMs) and detected with the ATLAS FE-I3 Pixel Application Specific Integrated Circuit (ASIC). We report on performance characterization of the detector, including measurements of gain, gain resolution, point resolution, diffusion, angular resolution, and energy resolution with low-energy x-rays, cosmic rays, and alpha particles, using the gases Ar:CO$_2$ (70:30) and He:CO$_2$ (70:30) at atmospheric pressure. We discuss the implications for future, larger directional neutron and Dark Matter detectors. With an eye to designing and selecting components for these, we generalize our results into analytical expressions for detector performance whenever possible. We conclude by demonstrating the 3-D directional detection of a fast neutron source.
description: 14 pages, 17 figures
Análisis multicriterio para la política de uso en la barra del Estero de Punta Banda, B. C., México /
Creators: name: Sepulveda Trujillo, Marco Antonio.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: HC79 .E5 S46 1998

description: La planificación ambiental del territorio es algo cada vez más necesario, tanto para obtener un desarrollo económico adecuado, como para mantener la calidad del ambiente de manera de no sobrepasar su capacidad de carga, volviéndose en contra del mismo hombre (desarrollo sustentable).
Propensity Score Estimation to Address Calendar Time-Specific Channeling in Comparative Effectiveness Research of Second Generation Antipsychotics
Creators: name: Dusetzina, Stacie B.
name: Stürmer, Til
name: Mack, Christina D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundChanneling occurs when a medication and its potential comparators are selectively prescribed based on differences in underlying patient characteristics. Drug safety advisories can provide new information regarding the relative safety or effectiveness of a drug product which might increase selective prescribing. In particular, when reported adverse effects vary among drugs within a therapeutic class, clinicians may channel patients toward or away from a drug based on the patient's underlying risk for an adverse outcome. If channeling is not identified and appropriately managed it might lead to confounding in observational comparative effectiveness studies.ObjectiveTo demonstrate channeling among new users of second generation antipsychotics following a Food and Drug Administration safety advisory and to evaluate the impact of channeling on cardiovascular risk estimates over time.Data SourceFlorida Medicaid data from 2001–2006.Study DesignRetrospective cohort of adults initiating second generation antipsychotics. We used propensity scores to match olanzapine initiators with other second generation antipsychotic initiators. To evaluate channeling away from olanzapine following an FDA safety advisory, we estimated calendar time-specific propensity scores. We compare the performance of these calendar time-specific propensity scores with conventionally-estimated propensity scores on estimates of cardiovascular risk.Principal FindingsIncreased channeling away from olanzapine was evident for some, but not all, cardiovascular risk factors and corresponded with the timing of the FDA advisory. Covariate balance was optimized within period and across all periods when using the calendar time-specific propensity score. Hazard ratio estimates for cardiovascular outcomes did not differ across models (Conventional PS: 0.97, 95%CI: 0.81–3.18 versus calendar time-specific PS: 0.93, 95%CI: 0.77–3.04).ConclusionsChanges in channeling over time was evident for several covariates but had limited impact on cardiovascular risk estimates, possibly due to unmeasured confounding. Although calendar time-specific propensity scores appear to improve covariate balance, the impact on comparative effectiveness results is limited in this setting.
Propuesta de estrategia metodológica para la aplicación de proyectos de huertos en casas hogar con enfoque en educación ambiental :
Creators: name: Salgado Rodríguez, Noemí.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Ciencias||Tesis y disertaciones académicas||Actitudes ambientales
subject: GE90.M6 S35 2022

description: Hay múltiples experiencias documentadas en el mundo, pocas en México y ninguna en BC. El objetivo de esta tesis consistía en el diseño de una estrategia para implementar un proyecto del huerto bajo las condiciones y situaciones específicas de una casa hogar con 18 niños vulnerables (“Hogar para niños necesitados del Sauzal, A.C.”). La investigación es de corte etnográfico, por medio de la observación participante. Se lograron explorar los conocimientos, actitudes y comportamientos ambientales en los menores de la casa hogar, previos y posteriores al proyecto del huerto.
Protease Activated Receptor-2 Contributes to Heart Failure
Creators: name: Mackman, Nigel
name: Pawlinski, Rafal
name: Rojas, Mauricio
name: Sparkenbaugh, Erica M.
name: Antoniak, Silvio
name: Tencati, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Heart failure is a major clinical problem worldwide. Previous studies have demonstrated an important role for G protein-coupled receptors, including protease-activated receptors (PARs), in the pathology of heart hypertrophy and failure. Activation of PAR-2 on cardiomyocytes has been shown to induce hypertrophic growth in vitro. PAR-2 also contributes to myocardial infarction and heart remodeling after ischemia/reperfusion injury. In this study, we found that PAR-2 induced hypertrophic growth of cultured rat neonatal cardiomyocytes in a MEK1/2 and p38 dependent manner. In addition, PAR-2 activation on mouse cardiomyocytes increased expression of the pro-fibrotic chemokine MCP-1. Furthermore, cardiomyocyte-specific overexpression of PAR-2 in mice induced heart hypertrophy, cardiac fibrosis, inflammation and heart failure. Finally, in a mouse model of myocardial infarction induced by permanent ligation of the left anterior descending coronary artery, PAR-2 deficiency attenuated heart remodeling and improved heart function independently of its contribution to the size of the initial infarct. Taken together, our data indicate that PAR-2 signaling contributes to the pathogenesis of hypertrophy and heart failure.
Technology Mediated Sexual Interactions, Social Anxiety, and Sexual Wellbeing: A Scoping Review
Creators: name: Fehr, Cassandra
name: Braham, Justine
name: Ashbaugh, Andrea R.
name: Shaughnessy, Krystelle
name: Ashley, Marilyn
name: Corsini-Munt, Serena
name: Ouimet, Allison
name: Reissing, Elke
Publisher: name: Open Science Framework
Year: 2021
Subjects: subject: Social Psychology
subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: Other Psychology
subject: sexual communication
subject: technology mediated sexual interaction
subject: social anxiety
subject: sex
subject: anxiety
subject: TMSI
subject: technology

description: Scoping review project conducted at the University of Ottawa, Canada. Members of the project include several faculty members from the School of Psychology, and the Social Sciences Research Liaison Librarian.
Quantitative Analysis of Microbicide Concentrations in Fluids, Gels and Tissues Using Confocal Raman Spectroscopy
Creators: name: Chuchuen, Oranat
name: Henderson, Marcus H.
name: Kashuba, Angela D. M.
name: Katz, David F.
name: Kim, Min Sung
name: Sykes, Craig
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Topical vaginal anti-HIV microbicides are an important focus in female-based strategies to prevent the sexual transmission of HIV. Understanding microbicide pharmacokinetics is essential to development, characterization and implementation of efficacious microbicide drug delivery formulations. Current methods to measure drug concentrations in tissue (e.g., LC-MS/MS, liquid chromatography coupled with tandem mass spectrometry) are highly sensitive, but destructive and complex. This project explored the use of confocal Raman spectroscopy to detect microbicide drugs and to measure their local concentrations in fluids, drug delivery gels, and tissues. We evaluated three candidate microbicide drugs: tenofovir, Dapivirine and IQP-0528. Measurements were performed in freshly excised porcine buccal tissue specimens, gel vehicles and fluids using two Horiba Raman microscopes, one of which is confocal. Characteristic spectral peak calibrations for each drug were obtained using serial dilutions in the three matrices. These specific Raman bands demonstrated strong linear concentration dependences in the matrices and were characterized with respect to their unique vibrational signatures. At least one specific Raman feature was identified for each drug as a marker band for detection in tissue. Sensitivity of detection was evaluated in the three matrices. A specific peak was also identified for tenofovir diphosphate, the anti-HIV bioactive product of tenofovir after phosphorylation in host cells. Z-scans of drug concentrations vs. depth in excised tissue specimens, incubated under layers of tenofovir solution in a Transwell assay, showed decreasing concentration with depth from the surface into the tissue. Time-dependent concentration profiles were obtained from tissue samples incubated in the Transwell assay, for times ranging 30 minutes - 6 hours. Calibrations and measurements from tissue permeation studies for tenofovir showed good correlation with gold standard LC-MS/MS data. These results demonstrate that confocal Raman spectroscopy holds promise as a tool for practical, minimally invasive, label-free measurement of microbicide drug concentrations in fluids, gels and tissues.
Análisis del contexto educativo, pedagógico y buenas prácticas respecto a los resultados en los EGEL en la UABC
Creators: name: Mayoral Zúñiga, Aylin.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Educación||Tesis y disertaciones académicas||Política de educación superior||México Baja California (Estado).
subject: LC92.M6 M39 2022

description: La UABC utiliza los EGEL como valoración externa con fines de acreditación y calidad.
Australian Public Opinion Poll # 82
Creators: name: Australian Public Opinion Polls
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Race broadcasts (1); living costs (1); referendum on banning of Communist Party (1); Olympic Games in Melbourne (1); government-owned businesses (3); ways of stopping inflation (6); Federal vs State control of prices (2); Korean War (1); proposed Defence Pact U.S.A./Australia/New Zealand (1); proposed Japanese Peace Treaty (1); Japan having armed forces again (1).
Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo
Creators: name: Hartnett, M. Elizabeth
name: Quilliam, Lawrence A.
name: Chrzanowska-Wodnicka, Magdalena
name: Wittchen, Erika S.
name: Wang, Haibo
name: McCloskey, Manabu
name: Nishimura, Eiichi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Loss of barrier integrity precedes the development of pathologies such as metastasis, inflammatory disorders, and blood-retinal barrier breakdown present in neovascular age-related macular degeneration. Rap1 GTPase is involved in regulating both endothelial and epithelial cell junctions; the specific role of Rap1A vs. Rap1B isoforms is less clear. Compromise of retinal pigment epithelium barrier function is a contributing factor to the development of AMD. We utilized shRNA of Rap1 isoforms in cultured human retinal pigment epithelial cells, along with knockout mouse models to test the role of Rap1 on promoting RPE barrier properties, with emphasis on the dynamic junctional regulation that is triggered when the adhesion between cells is challenged. In vitro, Rap1A shRNA reduced steady-state barrier integrity, whereas Rap1B shRNA affected dynamic junctional responses. In a laser-induced choroidal neovascularization (CNV) model of macular degeneration, Rap1b−/− mice exhibited larger CNV volumes compared to wild-type or Rap1a−/−. In vivo, intravitreal injection of a cAMP analog (8CPT-2′-O-Me-cAMP) that is a known Rap1 activator significantly reduced laser-induced CNV volume, which correlated with the inhibition of CEC transmigration across 8CPT-2′O-Me-cAMP-treated RPE monolayers in vitro. Rap1 activation by 8CPT-2′-O-Me-cAMP treatment increased recruitment of junctional proteins and F-actin to cell-cell contacts, increasing both the linearity of junctions in vitro and in cells surrounding laser-induced lesions in vivo. We conclude that in vitro, Rap1A may be important for steady state barrier integrity, while Rap1B is involved more in dynamic junctional responses such as resistance to junctional disassembly induced by EGTA and reassembly of cell junctions following disruption. Furthermore, activation of Rap1 in vivo inhibited development of choroidal neovascular lesions in a laser-injury model. Our data suggest that targeting Rap1 isoforms in vivo with 8CPT-2′-O-Me-cAMP may be a viable pharmacological means to strengthen the RPE barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration.
Contact tracing of binary stars - from sub-solar to high-mass components
Creators: name: Henneco, Jan
name: Schneider, Fabian R. N.
name: Laplace, Eva
name: Wei, Dandan
name: Hekker, Saskia
Publisher: name: Zenodo
Year: 2022
Subjects: binaries
stellar mergers
contact binaries
common envelopes
simulations
stellar evolution

description: Stellar mergers produce massive single stars with potentially distinctive prop-
 erties. These include rejuvenated blue stragglers, highly magnetized (massive)
 stars, and stars with peculiar chemical abundances and rotation rates. The
 actual merger phases can be detected as luminous red novae. Before the merg-
 ing event itself, stars will enter a contact phase. However, entering such phase
 does not necessarily lead to a merger. Contact phases can be stable but also
 short lived. This is somewhat in analogy to common-envelope phases, which
 have a certain (currently unconstrained) survival rate for the involved binary.
 With the help of a large grid of detailed 1D binary models (~6000) spanning
 components masses from 0.5 to 20 solar masses, we assess which initial binary
 configurations might end up in a contact or common-envelope phase. Further-
 more, by exploring the different driving mechanisms towards and the structure
 of the components at the onset of these phases, we aim to predict whether a
 merger will occur. Additionally, the extended mass range allows for compar-
 isons between lower-mass and massive primary stars.
Real-scale fire test on piloti columns of urban living houses with FRP reinforcements
Creators: name: Choi, In-Rak
name: Park, Ji-Hye
name: Choi, Sung-Mo
name: Min, Jeong-Ki
name: Shin, Jin-Won
Publisher: name: figshare
Year: 2023
Subjects: Fire safety engineering

description: In this study, real-scale car fire test using mid-size sedan was conducted to verify the fire behavior of the piloti parking space and the fire-resistance performance of the surrounding column members due to the car fire. For the car fire test in the parking area, four columns were installed outside the parking line and roof structure was installed to describe the piloti parking space. During the fire test, heat release rate and temperatures of the inside and outside of the car and the inside of the column were measured. Thermal effect on the columns reinforced with FRP for seismic resistance were observed.
Rectal Transmission of Transmitted/Founder HIV-1 Is Efficiently Prevented by Topical 1% Tenofovir in BLT Humanized Mice
Creators: name: Denton, Paul W.
name: Chateau, Morgan L.
name: Swanson, Michael D.
name: Garcia, J. Victor
name: McGowan, Ian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Rectal microbicides are being developed to prevent new HIV infections in both men and women. We focused our in vivo preclinical efficacy study on rectally-applied tenofovir. BLT humanized mice (n = 43) were rectally inoculated with either the primary isolate HIV-1JRCSF or the MSM-derived transmitted/founder (T/F) virus HIV-1THRO within 30 minutes following treatment with topical 1% tenofovir or vehicle. Under our experimental conditions, in the absence of drug treatment we observed 50% and 60% rectal transmission by HIV-1JRCSF and HIV-1THRO, respectively. Topical tenofovir reduced rectal transmission to 8% (1/12; log rank p = 0.03) for HIV-1JRCSF and 0% (0/6; log rank p = 0.02) for HIV-1THRO. This is the first demonstration that any human T/F HIV-1 rectally infects humanized mice and that transmission of the T/F virus can be efficiently blocked by rectally applied 1% tenofovir. These results obtained in BLT mice, along with recent ex vivo, Phase 1 trial and non-human primate reports, provide a critically important step forward in the development of tenofovir-based rectal microbicides.
Current status of research on natural plants and their extracts for relieving alcohol hangovers: a scoping review protocol
Creators: name: Yao, Junjie
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Pharmacy and Pharmaceutical Sciences
subject: Physical Sciences and Mathematics
subject: Natural Products Chemistry and Pharmacognosy
subject: Medicine and Health Sciences
subject: Hangover
subject: Natural plants
subject: Scoping review

description: Alcohol hangover (veisalgia) is the most common adverse effect after drinking alcohol, and alcohol use disorder caused by long-term drinking has become a public health problem worldwide. We hope to investigate the literature evidence of natural plants and their extracts related to hangovers through the scoping review method to depict the current situation and provide information for in-depth research.
Can the intergalactic medium cause a rapid drop in Lyman alpha emission at z>6?
Creators: name: Mesinger, Andrei
name: Aykutalp, Aycin
name: Vanzella, Eros
name: Pentericci, Laura
name: Ferrara, Andrea
name: Dijkstra, Mark
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The large cross-section of the Lyman alpha (Lya) line makes it a sensitive probe of the ionization state of the intergalactic medium (IGM). Here we present the most complete study to date of the IGM Lya opacity, and its application to the redshift evolution of the 'Lya fraction', i.e. the fraction of color-selected galaxies with a detectable Lya emission line. We use a tiered approach, which combines large-scale semi-numeric simulations of reionization with moderate-scale hydrodynamic simulations of the ionized IGM. This allows us to simultaneously account for evolution in both: (i) the opacity from an incomplete (patchy) reionization, parameterized by the filling factor of ionized regions, Q_HII; and (ii) the opacity from self-shielded systems in the ionized IGM, parameterized by the average photo-ionization rate inside HII regions, Γ. In contrast to recent empirical models, attenuation from patchy reionization has a unimodal distribution along different sightlines, while attenuation from self-shielded systems is more bimodal. We quantify the average IGM transmission in our (Q_HII, Γ) parameter space, which can easily be used to interpret new data sets. Using current observations, we predict that the Lya fraction cannot drop by more than a factor of ~2 with IGM attenuation alone, even for HII filling factors as low as Q_HII>0.1. Larger changes in the Lya fraction could result from a co-evolution with galaxy properties. Marginalizing over Γ, we find that current observations constrain Q_HII < 0.6 at z=7 [68% confidence level (C.L.)]. However, all of our parameter space is consistent with observations at 95% C.L., highlighting the need for larger observational samples at z >= 6.
description: 12 pages, 10 figures, MNRAS submitted
Renal Proteome in Mice with Different Susceptibilities to Fluorosis
Creators: name: Labate, Carlos Alberto
name: Carvalho, Juliane Guimarães
name: Salvato, Fernanda
name: Peres-Buzalaf, Camila
name: Everett, Eric T.
name: Buzalaf, Marília Afonso Rabelo
name: Whitford, Gary Milton
name: Leite, Aline de Lima
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A/J and 129P3/J mouse strains have different susceptibilities to dental fluorosis due to their genetic backgrounds. They also differ with respect to several features of fluoride (F) metabolism and metabolic handling of water. This study was done to determine whether differences in F metabolism could be explained by diversities in the profile of protein expression in kidneys. Weanling, male A/J mice (susceptible to dental fluorosis, n = 18) and 129P3/J mice (resistant, n = 18) were housed in pairs and assigned to three groups given low-F food and drinking water containing 0, 10 or 50 ppm [F] for 7 weeks. Renal proteome profiles were examined using 2D-PAGE and LC-MS/MS. Quantitative intensity analysis detected between A/J and 129P3/J strains 122, 126 and 134 spots differentially expressed in the groups receiving 0, 10 and 50 ppmF, respectively. From these, 25, 30 and 32, respectively, were successfully identified. Most of the proteins were related to metabolic and cellular processes, followed by response to stimuli, development and regulation of cellular processes. In F-treated groups, PDZK-1, a protein involved in the regulation of renal tubular reabsorption capacity was down-modulated in the kidney of 129P3/J mice. A/J and 129P3/J mice exhibited 11 and 3 exclusive proteins, respectively, regardless of F exposure. In conclusion, proteomic analysis was able to identify proteins potentially involved in metabolic handling of F and water that are differentially expressed or even not expressed in the strains evaluated. This can contribute to understanding the molecular mechanisms underlying genetic susceptibility to dental fluorosis, by indicating key-proteins that should be better addressed in future studies.
Representation of Women and Pregnant Women in HIV Research: A Limited Systematic Review
Creators: name: Schwartz, Sheree
name: Swamy, Geeta
name: Westreich, Daniel
name: Rosenberg, Molly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundHIV-related outcomes may be affected by biological sex and by pregnancy. Including women in general and pregnant women in particular in HIV-related research is important for generalizability of findings.ObjectiveTo characterize representation of pregnant and non-pregnant women in HIV-related research conducted in general populations.Data SourcesAll HIV-related articles published in fifteen journals from January to March of 2011. We selected the top five journals by 2010 impact factor, in internal medicine, infectious diseases, and HIV/AIDS.Study Eligibility CriteriaHIV-related studies reporting original research on questions applicable to both men and women of reproductive age were considered; studies were excluded if they did not include individual-level patient data.Study appraisal and synthesis methods.Articles were doubly reviewed and abstracted; discrepancies were resolved through consensus. We recorded proportion of female study participants, whether pregnant women were included or excluded, and other key factors.ResultsIn total, 2014 articles were published during this period. After screening, 259 articles were included as original HIV-related research reporting individual-level data; of these, 226 were determined to be articles relevant to both men and women of reproductive age. In these articles, women were adequately represented within geographic region. The vast majority of published articles, 183/226 (81%), did not mention pregnancy (or related issues); still fewer included pregnant women (n=33), reported numbers of pregnant women (n=19), or analyzed using pregnancy status (n=9).LimitationsData were missing for some key variables, including pregnancy. The time period over which published works were evaluated was relatively short.Conclusions and implications of key findings.The under-reporting and inattention to pregnancy in the HIV literature may reduce policy-makers’ ability to set evidence-based policy around HIV/AIDS care for pregnant women and women of child-bearing age.
A Theory of Mass Transfer in Binary Stars
Creators: name: Cehula, Jakub
Publisher: name: Zenodo
Year: 2022
Subjects: binary stars
mass transfer

description: Mass transfer in binary stars is an ubiquitous phenomenon that dramatically affects their evolution. Current mass transfer prescriptions used in stellar evolution codes suffer from several conceptual and practical problems. To solve these issues, we develop a new model of binary mass transfer through the inner Lagrange point, based on the assumption that the Roche potential sets up a converging-diverging nozzle around the Lagrange point. By averaging 3D time-steady Euler equations, we derive a set of 1D hydrodynamic equations governing the gas flow, in which mass-transfer rate is the eigenvalue of the system. The inner boundary condition directly relates our model to the structure of the star obtained, for example, from MESA stellar evolution code. Our model predicts mass-transfer rates within a few percent of the existing prescriptions using a polytropic equation of state. In the case of a more sophisticated equation of state, such as the one provided by the MESA EOS module, the mass-transfer rates obtained are lower than current prescriptions (up to a factor of 4) in the case of a realistic situation of a massive star experiencing intensive thermal-timescale mass transfer. Our results suggest that conceptual uncertainties in the treatment of mass transfer significantly affect conditions for L2 overflow and binary stability against common envelope evolution, making them more likely to occur. Our model could be included in stellar evolution codes like MESA with relatively small increase in computational cost. As a next step, we will include additional physics in our model, such as radiation and magnetic fields.
Propuesta de ordenamiento de uso del suelo para la zona costera del municipio de Tijuana, Baja California /
Creators: name: Altuna Renedo, Naiara.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: uso de suelo||Planificación||Baja California Tijuana||Costas||Erosión||Baja California Tijuana||Oceanografía||Administración de recursos marinos||Tesis.
subject: HD108.6 A58 2004

description: Este estudio elaboró la regionalización, precisó políticas y estableció los lineamientos generales para el manejo de los recursos, centrándose en la zona costera terrestre del muncipio de Tijuana, de manera que permita un estudio mas detallado a una escala 1:10 000.