cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy
Creators: name: Blair, Andrew M.
name: Liu, Baorui
name: Chen, Gang
name: Bian, Xinyu
name: Cao, Peng
name: Chen, Jiao
name: Huang, Leaf
name: Xin, Kai
name: Zou, Zhengyun
name: Sha, Huizi
name: Cai, Xueting
name: Lu, Wuguang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Human tumors, including gastric cancer, frequently express high levels of epidermal growth factor receptors (EGFRs), which are associated with a poor prognosis. Targeted delivery of anticancer drugs to cancerous tissues shows potential in sparing unaffected tissues. However, it has been a major challenge for drug penetration in solid tumor tissues due to the complicated tumor microenvironment. We have constructed a recombinant protein named anti-EGFR-iRGD consisting of an anti-EGFR VHH (the variable domain from the heavy chain of the antibody) fused to iRGD, a tumor-specific binding peptide with high permeability. Anti-EGFR-iRGD, which targets EGFR and αvβ3, spreads extensively throughout both the multicellular spheroids and the tumor mass. The recombinant protein anti-EGFR-iRGD also exhibited antitumor activity in tumor cell lines, multicellular spheroids, and mice. Moreover, anti-EGFR-iRGD could improve anticancer drugs, such as doxorubicin (DOX), bevacizumab, nanoparticle permeability and efficacy in multicellular spheroids. This study draws attention to the importance of iRGD peptide in the therapeutic approach of anti-EGFR-iRGD. As a consequence, anti-EGFR-iRGD could be a drug candidate for cancer treatment and a useful adjunct of other anticancer drugs.
Interpretation of quantum theory: the quantum "grue-bleen" problem
Creators: name: Schumacher, Benjamin
name: Westmoreland, Michael D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a critique of the many-world interpretation of quantum mechanics, based on different ``pictures'' that describe the time evolution of an isolated quantum system. Without an externally imposed frame to restrict these possible pictures, the theory cannot yield non-trivial interpretational statements. This is analogous to Goodman's famous ``grue-bleen'' problem of language and induction. Using a general framework applicable to many kinds of dynamical theories, we try to identify the kind of additional structure (if any) required for the meaningful interpretation of a theory. We find that the ``grue-bleen'' problem is not restricted to quantum mechanics, but also affects other theories including classical Hamiltonian mechanics. For all such theories, absent external frame information, an isolated system has no interpretation.
description: 30 pages, 1 figure
Transits of Planets with Small Intervals in Circumbinary Systems
Creators: name: Liu, Hui-Gen
name: Wang, Ying
name: Zhang, Hui
name: Zhou, Ji-Lin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Transit times around single stars can be described well by a linear ephemeris. However, transit times in circumbinary systems are influenced both by the gravitational perturbations and the orbital phase variations of the central binary star. Adopting a coplanar analog of Kepler-16 as an example, we find that circumbinary planets can transit the same star more than once during a single planetary orbit, a phenomenon we call "tight transits". In certain geometric, the projected orbital velocity of the planet and the secondary star can approach zero and change sign, resulting in very long transits and/or 2-3 transits during a single binary orbit. Whether tight transits are possible for a particular system depends primarily on the binary mass ratio and the orbital architecture of both the binary and the planet. We derive a time-dependent criterion to judge when tight transits are possible for any circumbinary system. These results are verified with full dynamical integrations that also reveal other tight transit characteristics, i.e., the transit durations and the intervals between tight transits. For the seven currently known circumbinary systems, we estimate these critical parameters both analytically and numerically. Due to the mutual inclination between the planet and the binary, tight transits can only occur across the less massive star B in Kepler-16, -34, -35, and -47 (for both planets). The long-term average frequency of tight transits (compared to typical transits) for Kepler-16, -34, and -35 are estimated to be several percent. Using full numerical integrations, the next tight transit for each system is predicted and the soonest example appears to be Kepler-47b and -47c, which are likely to have tight transits before 2025. These unique and valuable events often deserve special observational scrutiny.
description: 10 pages, 5 figures, Accepted by ApJ, 2014, 790, 1
title: Alfred Binet (1857-1911) : theoretical and empirical contributions to the study of intelligence.
Creators: name: Patricia. Faber, Diana
Publisher: name: University of Liverpool Repository
Year: 2023

description: The myth that Binet's Intelligence Scales were created "overnight" has already been dismissed by Theta Wolf (1969 and 1973). However, it was felt that there was still more to be explained about the Scales. The aim of this research therefore, was to explore and throw light on the many factors involved in the making of this experimental psychologist and his contribution to the study of intelligence in the late nineteenth and first decade of the twentieth century. In line with the modern approach that makes the consideration of social factors a sine qua non of an historical account of scientific achievement, the following aspects of France and its culture were explored: the politics which pressed with optimism for free and universal education; the institutional arrangements of the New University of Paris and their implications for Binet's career; the power of medical discourse which provided the framework within which both clinical and educational concerns were articulated; the broader intellectual "climate" in which scientific ideas were disseminated, and the particular intellectual influences on Binet himself . Binet's work is also seen as operating at the day-to-day level with all its practical demands: for example, his search for subjects, visits to hospices and schools. Binet was essentially a practical and patient researcher, giving particular attention to detail within experiments and in observing subjects' behaviour. By comparing Binet's views and practice with those of other psychologists of his time, for instance Ebbinghaus, Wundt, Galton, Cattell and Spearman, the originality of Binet's psychology is highlighted. This research has shown more clearly than elsewhere how Binet came to practise the, psychology that he did, and how his flexibility enabled the transforlnation of a psychological experiment into a test item. It is proposed that the particular social nature of his experiments and use of introspections were contributing factors. To understand the nature of his achievement it was found necessary to describe the genesis of the Scales through Binet's experimental work in "Individual Psychology" and his studies of children, and to examine the items of the Scales themselves. Historical accounts of nineteenth century France frequently contain comments on the power of ·the medical profession. The case of Binet illustrates this finding: I have proposed that the doctors' power created obstacles both potential and actual to the recognition of Binet's experimental work. Within the context of the Pedagogical Society and through a series of events medical power was shifted to allow for the psychologist to construct the diagnostic tool for assessing children's intelligence. Finally, the Intelligence Scales provoked reactions which generated controversy about the nature of intelligence and its measurement, and these are discussed in this thesis.
Using exosomes, naturally-equipped nanocarriers, for drug delivery
Creators: name: Kim, Myung Soo
name: Batrakova, Elena V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Exosomes offer distinct advantages that uniquely position them as highly effective drug carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes are known to specialize in cell–cell communications and provide an exclusive approach for the delivery of various therapeutic agents to target cells. In addition, exosomes can be amended through their parental cells to express a targeting moiety on their surface, or supplemented with desired biological activity. Development and validation of exosome-based drug delivery systems are the focus of this review. Different techniques of exosome isolation, characterization, drug loading, and applications in experimental disease models and clinic are discussed. Exosome-based drug formulations may be applied to a wide variety of disorders such as cancer, various infectious, cardiovascular, and neuro-degenerative disorders. Overall, exosomes combine benefits of both synthetic nanocarriers and cell-mediated drug delivery systems while avoiding their limitations.
Underlying mechanisms in the relationship between Africentric worldview and depressive symptoms.
Creators: name: Seaton, Eleanor K.
name: Townsend, Tiffany G.
name: Neblett, Enrique W.
name: Hammond, Wizdom Powell
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: This study examines underlying mechanisms in the relationship between an Africentric worldview and depressive symptoms. Participants were 112 African American young adults. An Africentric worldview buffered the association between perceived stress and depressive symptoms. The relationship between an Africentric worldview and depressive symptoms was mediated by perceived stress and emotion-focused coping. These findings highlight the protective function of an Africentric worldview in the context of African Americans’ stress experiences and psychological health and offer promise for enhancing African American mental health service delivery and treatment interventions.
HD 166620: Portrait of a Star Entering a Grand Magnetic Minimum
Creators: name: Luhn, Jacob K.
name: Wright, Jason T.
name: Henry, Gregory W.
name: Saar, Steven H.
name: Baum, Anna C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: HD 166620 was recently identified as a Maunder Minimum candidate based on nearly 50 years of Ca II H & K activity data from Mount Wilson and Keck-HIRES (Baum et al. 2022). These data showed clear cyclic behavior on a 17-year timescale during the Mount Wilson survey that became flat when picked up later with Keck-HIRES planet-search observations. Unfortunately, the transition between these two data sets -- and therefore the transition into the candidate Maunder Minimum phase -- contained little to no data. Here we present additional Mount Wilson data not present in Baum et al. (2022) along with photometry over a nearly 30-year baseline that definitively trace the transition from cyclic activity to a prolonged phase of flat activity. We present this as conclusive evidence of the star entering a grand magnetic minimum and therefore the first true Maunder Minimum analog. We further show that neither the overall brightness nor the chromospheric activity level (as measured by S$_{\mathrm{HK}}$) is significantly lower during the grand magnetic minimum than its activity cycle minimum, implying that anomalously low mean or instantaneous activity levels are not a good diagnostic or criterion for identifying additional Maunder Minimum candidates. Intraseasonal variability in S$_{\mathrm{HK}}$, however, is lower in the star's grand minimum; this may prove a useful symptom of the phenomenon.
description: 6 pages, 1 figure, submitted to ApJL
Characteristics of abstainers from substance use and antisocial behavior in the United States
Creators: name: Howard, Matthew O.
name: Perron, Brian E.
name: Vaughn, Michael G.
name: Wernet, Stephen J.
name: DeLisi, Matt
name: Fu, Qiang
name: Beaver, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Whether lifetime abstainer’s antisocial behavior are maladjusted or well-adjusted is unresolved. The aim of this study was to compare abstainers (defined as persons with no lifetime use of alcohol and other drugs and non-engagement in antisocial or delinquent behavior) with non-abstainers across a range of sociodemographic and mental health characteristics in the United States.
Semi-microscopic theory of two proton emission
Creators: name: Ghinescu, S. A.
name: Delion, D. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose a semi-microscopic model for the simultaneous emission of two protons. This model has the advantage of avoiding certain technical aspects of a fully microscopic 3-body framework, while also allowing the investigation of the influence of proton pairing on the total lifetime of the decaying nucleus. Thus, we use the standard singlet two-proton wave function on the nuclear surface, provided by the Bardeen-Cooper-Schrieffer (BCS) approach, as a boundary condition for the propagator operator. Our model allows for the estimation of all quantities related to the $2p$ emission process, since it provides the 3-body wave function over most of the domain. We show that reasonable agreement with experimental values can be reached by varying the $pp$ pairing strength outside the nucleus in an interval close to the "bare" singlet value.
Penha.et.al_tables_figures_ESM from Haemosporidian parasites and incubation period influence plumage coloration in tanagers (Passeriformes: Thraupidae)
Creators: name: Aguiar de Souza Penha, Victor
name: Maia Chaves Bicalho Domingos, Fabricius
name: Fecchio, Alan
name: Bell, Jeffrey A.
name: Weckstein, Jason D.
name: Ricklefs, Robert E.
name: Braga, Erika Martins
name: de Abreu Moreira, Patrícia
name: Soares, Leticia
name: Latta, Steven
name: Tolesano-Pascoli, Graziela
name: Alquezar, Renata Duarte
name: Del-Claro, Kleber
name: Manica, Lilian Tonelli
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Here we provide two tables containing summary results (Supplementary Table 1) and statistical models (Supplemental Table 2) used in the main document. Also, Supplementary Table 2 contains relevant information from all models used in the manuscript (predictors from each model, weight, AIC, and delta AIC values). We also provide all additional figures (Figure 1 to Figure 12) with non-statistically significant results from models relating plumage dichromatism and complexity to parasitism to haemosporidian parasites, body length, and investment in reproduction (clutch size and incubation period).
The Time Structure of Hadronic Showers in Calorimeters with Scintillator and with Gas Readout
Creators: name: Szalay, Marco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Hadronic showers are characterized by a rich particle structure in the spatial as well as in the time domain. The prompt component comes from relativistic fragments that deposit energy at the ns scale, while late components are associated predominantly with neutrons in the cascade. To measure the impact of these late components, two experiments, based on gaseous and plastic active layers with steel and tungsten absorbers, were set up. The different choice for the material of the active layers produces distinct responses to neutrons, and consequently to late energy depositions. After discussing the technical aspects of these systems, we present a comparison of the signals, read out with fast digitizers with deep buffers, and provide detailed information of the time structure of hadronic showers over a long sampling window.
description: proceeding for CALOR2014, 6 pages, 5 figures
The Severe 5%: A Latent Class Analysis of the Externalizing Behavior Spectrum in the United States
Creators: name: Fu, Qiang
name: Perron, Brian E.
name: Beaver, Kevin M.
name: Vaughn, Michael G.
name: DeLisi, Matt
name: Gunter, Tracy
name: Howard, Matthew O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Criminological research consistently demonstrates that approximately 5% of study populations are comprised of pathological offenders who account for a preponderance of antisocial behavior and violent crime. Unfortunately, there have been no nationally representative epidemiological studies characterizing the severe 5% group.
The relationship between positive end-expiratory pressure and cardiac index in patients with acute respiratory distress syndrome
Creators: name: Carson, Shannon S.
name: Fares, Wassim H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To evaluate the association between positive end-expiratory pressure (PEEP) and cardiac index in patients with acute respiratory distress syndrome (ARDS).
Generalised model-independent characterisation of strong gravitational lenses VIII. automated multi-band feature detection to constrain local lens properties
Creators: name: Lin, Joyce
name: Wagner, Jenny
name: Griffiths, Richard E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: As established in previous papers of this series, observables in highly distorted and magnified multiple images caused by the strong gravitational lensing effect can be used to constrain the distorting properties of the gravitational lens at the image positions. If the background source is extended and contains substructure, like star forming regions, which is resolved in multiple images, all substructure that can be matched across a minimum of three multiple images can be used to infer the local distorting properties of the lens. In this work, we replace the manual feature selection by an automated feature extraction based on SExtractor for Python and show its superior performance. Despite its aimed development to improve our lens reconstruction, it can be employed in any other approach, as well. Valuable insights on the definition of an `image position' in the presence of noise are gained from our calibration tests. Applying it to observations of a five-image configuration in galaxy cluster CL0024 and the triple-image configuration containing Hamilton's object, we determine local lens properties for multiple wavebands separately. Within current confidence bounds, all of them are consistent with each other, corroborating the wavelength-independence of strong lensing and offering a tool to detect deviations caused by micro-lensing and dust in further examples.
description: 19 pages, 23 figures, typos corrected, submitted to MNRAS, comments welcome
Modeling social actions in relationships as recursive inference
Creators: name: Thomas, Ashley J.
name: Hung, Michelle S
name: Tenenbaum, Joshua
name: Radkani, Setayesh
name: Saxe, Rebecca
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: In this project, we explore the idea that people view food sharing actions as “bids” to reveal the type and closeness of a relationship. We use a modified Rational Speech Act framework to model the recursive inferences that food sharing interactions allow.
Risk factors for depression in the elderly inflammatory bowel disease population
Creators: name: Kappelman, Michael D.
name: Chen, Wenli
name: Anton, Kristen
name: Long, Millie D.
name: Sandler, Robert S.
name: Martin, Christopher F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Little is known about depression in elderly individuals with inflammatory bowel diseases (IBD). We assessed the point prevalence of depression and determined associations with disease activity, quality of life, and medication adherence in elderly patients with IBD.
xzzaFkky;hu lsokae/;s lkekftd ek/;ekapk okij
Creators: name: Izk-Lat; Egknso Nsodj-
Publisher: name: Zenodo
Year: 2022
Subjects: lkekftd ek/;es] OgkWVlvi] ;qV;qc] Qslcqd] bULVªkxzake] fVoVj] f¶ydj fyadMbu] fiaVjsLV

description: ‘kS{kf.kd xzaFkky;kaP;k v/;;u v/;kiu izfdz;srhy mi;qDrrsckcr tkx#drk fuekZ.k dj.;klkBh lkekftd ek/;ekapk okij vifjgk;Z >kysyk vkgs- vkt loZ txke/;s brjka’kh laokn lk/k.;klkBh ,d izHkkoh ek/;e vkgs- ;knokjs okijdrkZ QksVks] fOgfMvks] xk.kh ;kaps vknku iznku dj.;klkBh baVjusV vk/kkjhr ra=Kkukpk okij d#u lkekftd ek/;ekanokjs vknku iznku dsysY;k lsokapk vLokn lgtfjR;k ?ksm ‘kdrks- izR;sdkP;k eksckbye/;s vkt lkekftd ek/;es lgtfjR;k miyC/k vkgsr- ;ke/;s OgkWVlvi] ;qV;qc] Qslcqd]bULVªkxzake]fVoVj]f¶ydj fiaVjsLV vkf.k fyadMbu bR;knh ek/;ekrqu xzaFkky;s lqènk vkiY;k xzaFkky;hu lsok miHkksDR;ki;Zar iksgpm ‘kdrks-;krqu okpdoxZ eksB;k izek.kkr ok<qu xzaFkky;kfo”k;h miHkksDR;kauk ekfgrh feGsy o ,desdka’kh ekfgrhps vknku iznku djrhy-
Inclusive $J/ψ$ photoproduction at the ILC within the framework of non-relativistic QCD
Creators: name: Zhan, Xi-Jie
name: Wu, Xing-Gang
name: Zheng, Xu-Chang
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Based on the non-relativistic quantum chromodynamics factorization framework, we study the inclusive $J/ψ$ photoproduction at the future high energy $e^+e^-$ collider, International Linear Collider(ILC), where the initial photons come from the back-scattering of laser and electron (positron). The intermediate states, $c\bar{c}$$({}^3\!S_1^{[\textbf{1}]}$,${}^1\!S_0^{[\textbf{8}]}$,${}^3\!S_1^{[\textbf{8}]}$,${}^3\!P_{0,1,2}^{[\textbf{8}]})$, and resolved photoproduction processes are considered. Numerical results show that the cross section of $J/ψ$ photoproduction at the ILC could be very large, and the single resolved process via $c\bar{c}({}^1\!S_0^{[\textbf{8}]})$ intermediate state dominates primarily the production. We also present various kinematic distributions for $J/ψ$ photoproduction. Combining the high luminosity of the collision, $J/ψ$ photoproduction at the ILC shall provide a good platform to test the NRQCD factorization.
description: 13 pages,7 figures,3 tables
A statefinder luminosity distance formula in varying speed of light cosmology
Creators: name: Balcerzak, Adam
name: Dabrowski, Mariusz P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We derive a luminosity distance formula for the varying speed of light (VSL) theory which involves higher order characteristics of expansion such as jerk, snap and lerk which can test the impact of varying $c$ onto the evolution of the universe. We show that the effect of varying $c$ is possible to be isolated due to the relations connecting observational parameters already by measuring the second-order term in redshift $z$ unless there is a redundancy between the curvature and an exotic fluid of cosmic strings scaling the same way as the curvature.
description: 6 pages, REVTEX 4-1, no figures. arXiv admin note: substantial text overlap with arXiv:1310.7231
Accretion in massive colliding wind binaries and the effect of wind momentum ratio
Creators: name: Kashi, Amit
name: Michaelis, Amir
name: Kaminetsky, Yarden
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We carry out a numerical experiment of ejecting winds in a massive colliding wind binary system, and quantifying the accretion onto the secondary star under different primary mass loss rates. We set a binary system comprising a Luminous Blue Variable (LBV) as the primary and a Wolf-Rayet (WR) star as the secondary, and vary the mass loss rate of the LBV to obtain different values of wind momentum ratio $η$. Our simulations include two sets of cases: one where the stars are stationary, and one that includes the orbital motion. As $η$ decreases the colliding wind structure moves closer to the secondary. We find that for $η\lesssim 0.05$ the accretion threshold is reached and clumps which originate by instabilities are accreted onto the secondary. For each value of $η$ we calculate the mass accretion rate and identify different regions in the $\dot{M}_{\rm acc}$ - $η$ diagram. For $0.001 \lesssim η\lesssim 0.05$ the accretion is sub- Bondi-Hoyle-Lyttleton (BHL) and the average accretion rate satisfies the power-law $\dot{M}_{\rm acc} \propto η^{-1.73}$ for static stars. The accretion is not continuous but rather changes from sporadic to a larger duty cycle as $η$ decreases. For $η\lesssim0.001$ the accretion becomes continuous in time and the accretion rate is BHL, up to a factor of 0.4--0.8. The simulations that include the orbital motion give qualitatively similar results, with the steeper power law $\dot{M}_{\rm acc} \propto η^{-1.86}$ for the sub-BHL region and lower $η$ as an accretion threshold.
description: Accepted for publication in MNRAS
Dialogo interculturale e didattica: il luogo d’incontro per la formazione degli alunni stranieri. L’importanza pedagogica della narrazione
Creators: name: Cioffi, Maria
Publisher: name: Universita degli studi di Salerno
Year: 2011
Subjects: subject: M-PED/04 PEDAGOGIA SPERIMENTALE
subject: Intercultura

description: 2009 - 2010
description: Il lavoro posto in essere in questo scritto è rivolto all'analisi dei motivi che in questi decenni hanno fortemente influenzato e mutato il volto dell'educazione. Tali motivi sono da ricercarsi nel fatto che alcuni obiettivi educativi sono divenuti prioritari, il sistema “classe” è diventato sempre più articolato ed eterogeneo e, soprattutto che la ricerca psicopedagogica ha mutato il panorama dei temi della cognizione, dell'insegnamento e dell'apprendimento. Una delle ragioni che hanno fortemente influenzato il modo di approcciarsi alla vita “didattica” della classe è da ricercare, nel rapporto esistente fra le diverse culture all'interno di una società che è divenuta e continua a plasmarsi e configurarsi sempre più come multietnica. Oggi è noto che la diversità e le differenze culturali in classe siano fonte di risorsa e non di ostacolo. L'educazione interculturale, che rappresenta la “traduzione” didattica della pedagogia interculturale, è una prospettiva di ricerca e una prassi pedagogica che nasce dalla necessità di un inserimento attivo degli allievi stranieri nella scuola e da un ripensamento critico dei saperi fondamentali attualmente insegnati. Essa non è una nuova materia né una pedagogia speciale per stranieri; si configura, al contrario, come un nuovo asse educativo rivolto in primo luogo ai paesi di “accoglienza” e volto a modificare abiti cognitivi e comportamenti degli indigeni e degli stranieri. .. [a cura dell'Autore]
title: The legal status of the Gulf of Sirte in international law.
Creators: name: Abdulgader. Emberesh, Elhagi
Publisher: name: University of Liverpool Repository
Year: 2023

description: In 1973 Libya claimed the Gulf of Sirte. Its claim was based on historic and vital interests and it stated that the Gulf was part of Libyan internal waters over which Libya exerts full sovereignty and that the Gulf was an historic or vital bay. The thesis analyses the Libyan historic and/or vital bay claim over the Gulf. Although the doctrine of historic and/or vital bays is not codified, it is not a new doctrine in international law. It is argued that, as an exception to the general rules on bays, the coastal State has the right, by virtue of historic and vital interests, to claim and appropriate a bay adjacent to its coast. Chapter one deals with the scope of the research including the legal significance of the claim to Libya. The chapter discusses the methodology used and reviews the 1973 Declaration and international reaction to it, including the US-Libyan incidents. The geographical and historical background of the Gulf of sirte are also reviewed. In chapter two the evolution of the concepts of bays, historic bays and waters in international law are discussed. The chapter deals with definitional issues, the evolution and codification of the law of bays, and assess the law applicable in the field of historic and/or vital bays, and the requirements of customary international law. Chapter three analyses the Libyan immemorial usage and the effective Libyan exercise of sovereignty over the Gulf of sirte. Chapter four discusses the concept of acquiescence and whether there has been international acquiescence in the Libyan claim. Chapter five deals with the concept of protest and its application to the Libyan claim. It analyses the protests made at the Libyan claim and discusses a number of the protests made by States which have made similar claims to that of Libya. The issue of re~!procity is examined prior to detailed consideration and evaluation of the protests. Chapter six discusses the vital bay theory in a theoretical context, in state practice and its implementation by the tribunals. It also analyses the Libyan vital interest9s in the Gulf of Sirte and assesses the Libyan vital bay claim. Finally, chapter seven provides an overview of the Libyan historic and vital bay claim over the Gulf of sirte in a regional framework and in the context of the changing law of the sea. Proposals are made concerning the formulation of new rules when necessary on the codification of existing rules, on State practice and emerging trends relating to historic and/or vital bays. It is recommended that special attention should be given to the legitimate and genuine interests and needs of coastal States and the proposals made by Developing States in this regard.
Solving the matrix exponential function for the groups SU(3), SU(4) and Sp(2)
Creators: name: Kaiser, Norbert
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The well known analytical formula for $SU(2)$ matrices $U = \exp(i \vec τ\!\cdot\! \vec φ\,) = \cos|\vec φ\,| + i\vec τ\!\cdot\! \hatφ\, \sin|\vec φ\,|$\\ is extended to the $SU(3)$ group with eight real parameters. The resulting analytical formula involves the sum over three real roots of a cubic equation, corresponding to the so-called irreducible case, where one has to employ the trisection of an angle. When going to the special unitary group $SU(4)$ with 15 real prameters, the analytical formula involves the sum over four real roots of a quartic equation. The associated cubic resolvent equation with three positive roots belongs again to the irreducible case. Furthermore, by imposing the pertinent condition on $SU(4)$ matrices one can also treat the symplectic group $Sp(2)$ with ten real parameters. Since there the roots occur as two pairs of opposite sign, this simplifies the analytical formula for $Sp(2)$ matrices considerably. An outlook to the situation with analytical formulas for $SU(5)$, $SU(6)$ and $Sp(3)$ is also given.
description: 8 pages, 4 figures
Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients
Creators: name: Alexis, Neil E.
name: Noah, Terry L.
name: Peden, David B.
name: Muhlebach, Marianne S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Recent reports suggest that endotoxin exposure can blunt phagocyte functions. The aim of this study was to examine whether lung phagocytic cells have altered host defense function in young cystic fibrosis (CF) patients, and to explore the contribution of neutrophil elastase (NE) and surfactant proteins to these effects.
Enumeration and classification of self-orthogonal partial Latin rectangles by using the polynomial method
Creators: name: Falcón, Raúl M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The current paper deals with the enumeration and classification of the set $\mathcal{SOR}_{r,n}$ of self-orthogonal $r\times r$ partial Latin rectangles based on $n$ symbols. These combinatorial objects are identified with the independent sets of a Hamming graph and with the zeros of a radical zero-dimensional ideal of polynomials, whose reduced Gröbner basis and Hilbert series can be computed to determine explicitly the set $\mathcal{SOR}_{r,n}$. In particular, the cardinality of this set is shown for $r\leq 4$ and $n\leq 9$ and several formulas on the cardinality of $\mathcal{SOR}_{r,n}$ are exposed, for $r\leq 3$. The distribution of $r\times s$ partial Latin rectangles based on $n$ symbols according to their size is also obtained, for all $r,s,n\leq 4$.
description: 15 pages, 1 figure, 4 tables. Accepted for publication in European Journal of Combinatorics
Effects of lung transplantation on inpatient end of life care in cystic fibrosis
Creators: name: Noah, Terry L.
name: Dellon, Elisabeth P.
name: Yankaskas, James R.
name: Leigh, Margaret W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The impact of lung transplantation on end of life care in cystic fibrosis (CF) has not been widely investigated.
Pre-explosion, explosion, and post-explosion jets in supernova SN 2019zrk
Creators: name: Soker, Noam
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: I analyse some properties of the luminous transient event SN 2019zrk and conclude that jets were the main powering sources of the pre-explosion outburst (precursor) and ejection of a massive circumstellar matter (CSM), of the very energetic explosion itself, and of the post-explosion bump in the light curve. The pre-explosion energy source is mainly a companion (main sequence, Wolf-Rayet, neutron star or black hole) star that accreted mass and launched jets. I find that the fast expansion of the CSM after acceleration by the explosion ejecta requires the explosion energy to be >10^{52} erg. Only jet-driven explosions can supply this energy in such SN 2009ip-like transients. I conclude that ejecta-CSM interaction is extremely unlikely to power the bright bump at about 110 days after explosion. Instead, I show by applying a jet-driven bump toy-model that post-explosion jets are the most likely explanation for the bump. I leave open the question of whether the explosion itself (main outburst) was a core collapse supernova (CCSN) or a common envelope jets supernova (CEJSN). In this study I further connect peculiar transient events, here 2009ip-like transient events, to CCSNe by arguing that jets drive all events, from regular CCSNe through superluminous CCSNe and to many other peculiar and super-energetic transient events, including CEJSNe. Jet-powering cannot be ignored when analyzing all these types of transients.
description: Accepted for publication in MNRAS
Probing high-mass stellar evolutionary models with binary stars
Creators: name: Tkachenko, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Mass discrepancy is one of the problems that is pending a solution in (massive) binary star research field. The problem is often solved by introducing an additional near core mixing into evolutionary models, which brings theoretical masses of individual stellar components into an agreement with the dynamical ones. In the present study, we perform a detailed analysis of two massive binary systems, V380 Cyg and Sigma Sco, to provide an independent, asteroseismic measurement of the overshoot parameter, and to test state-of-the-art stellar evolution models.
description: 5 pages, 1 figure, 3 tables; proceedings of the IAU Symposium 307 held in Geneva in June 2014
Radiating Gravitational Collapse with an Initial Inhomogeneous Energy Density Distribution
Creators: name: Pinheiro, G.
name: Chan, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A new model is proposed to a collapsing star consisting of an initial inhomogeneous energy density and anisotropic pressure fluid with shear, radial heat flow and outgoing radiation. In previous papers one of us has always assumed an initial star with homogeneous energy density. The aim of this work is to generalize the previous models by introducing an initial inhomogeneous energy density and compare it to the initial homogeneous energy density collapse model. We will show the differences between these models in the evolution of all physical quantities that characterizes the gravitational collapse. The behavior of the energy density, pressure, mass, luminosity and the effective adiabatic index is analyzed. The pressure of the star, at the beginning of the collapse, is isotropic but due to the presence of the shear the pressure becomes more and more anisotropic. The black hole is never formed because the apparent horizon formation condition is never satisfied, in contrast of the previous model where a black hole is formed. An observer at infinity sees a radial point source radiating exponentially until reaches the time of maximum luminosity and suddenly the star turns off. In contrast of the former model where the luminosity also increases exponentially, reaching a maximum and after it decreases until the formation of the black hole. The effective adiabatic index is always positive without any discontinuity in contrast of the former model where there is a discontinuity around the time of maximum luminosity. The collapse is about three thousand times slower than in the case where the energy density is initially homogeneous.
description: 22 pages, 12 figures. This paper has already been published in GRG (2011). arXiv admin note: substantial text overlap with arXiv:1301.2540
He_supplementary data.docx
Creators: name: He
name: Zheng, Ruizhi
name: Zheng, Jie
name: Li, Mian
name: Wang, Tiange
name: zhao, zhiyun
name: Wang, Shuangyuan
name: Lin, Hong
name: Lu, Jieli
name: Chen, Yuhong
name: Xu, Yu
name: Wang, Weiqing
name: Xu, Min
name: Bi, Yufang
name: Ning, Guang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biomarkers
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: 110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine
subject: 110107 Metabolic Medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences

description: This is the supplement materia for the manuscript "Causal association between obesity, circulating glutamine levels, and depression: a Mendelian randomization study".
Le relazioni diplomatiche tra Santa Sede e Irlanda nel corso del Pontificato di Pio XI (1922-1939): i documenti dell'Archivio Segreto Vaticano
Creators: name: Di Sanzo, Donato
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: M-STO/04 STORIA CONTEMPORANEA
subject: Irlanda
subject: Vaticano
subject: Pio XI

description: 2012-2013
description: The dissertation Le relazioni diplomatiche tra Santa Sede e Irlanda nel corso del pontificato di Pio XI (1922-1939): i documenti dell’Archivio Segreto Vaticano is the final step of an historical research carried out during the Phd program in Sociologia, Analisi Sociale, Politiche Pubbliche e Teoria e Storia delle Istituzioni. The research focuses on the diplomatic relationship between the Holy See and Ireland during the papacy of Pius XI, from 1922 to 1939. Previous researches on the same topic, like Ireland and the Vatican. The Politics and Diplomacy of Church-State Relations 1922-1960 by the Irish Professor Dermot Keogh, didn’t consider the primary documentary sources from the Archivio Segreto Vaticano, that had been closed until 2006. For this reason, the dissertation is based on the crossing between the documents from the Holy See and the primary sources from the National Archives of Ireland. .. [edited by Author]
description: La tesi Le relazioni diplomatiche tra Santa Sede e Irlanda nel corso del pontificato di Pio XI (1922-1939): i documenti dell’Archivio Segreto Vaticano è il risultato di una ricerca storica condotta nei tre anni del dottorato di ricerca in Sociologia, Analisi Sociale, Politiche Pubbliche e Teoria e Storia delle Istituzioni. La ricerca verte sulle relazioni diplomatiche tra Santa Sede e Irlanda durante il papato di Pio XI, dunque tra il 1922 e il 1939. Precedenti lavori sullo stesso argomento, come Ireland and the Vatican. The Politics and Diplomacy of Church-State Relations 1922-1960 dello storico irlandense Dermot Keogh, non hanno potuto prendere in considerazione le fonti documentarie primarie conservate nell’ Archivio Segreto Vaticano, che è stato chiuso alla consultazione degli studiosi fino al 2006. Per tale ragione, la ricerca è focalizzata sull’ incrocio tra i documenti consultati in Santa Sede e le fonti primarie consultate negli Archivi Nazionali Irlandesi. .. [a cura dell'Autore]
Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice
Creators: name: Knowles, M.
name: Cuppens, H.
name: Kerem, B.
name: Claustres, M.
name: Dodge, J.
name: Rizzotti, P.
name: Doull, I.
name: Schwarz, M.
name: Cassiman, J.J.
name: Dequeker, E.
name: Casals, T.
name: Macek, M.
name: Bombieri, C.
name: Johannesson, M.
name: Durie, P.
name: Stuhrmann, M.
name: Castellani, C.
name: Elborn, J.S.
name: Ferec, C.
name: Zielenski, J.
name: Kerem, E.
name: Assael, B.M.
name: Pignatti, P.F.
name: Farrell, P.
name: Girodon, E.
name: Brown, A.
name: Tzetis, M.
name: Radojkovic, D.
name: Cutting, G.R.
name: Munck, A.
name: Tullis, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: It is often challenging for the clinician interested in cystic fibrosis (CF) to interpret molecular genetic results, and to integrate them in the diagnostic process. The limitations of genotyping technology, the choice of mutations to be tested, and the clinical context in which the test is administered can all influence how genetic information is interpreted. This paper describes the conclusions of a consensus conference to address the use and interpretation of CF mutation analysis in clinical settings.
Highlights of a workshop to discuss targeting inflammation in cystic fibrosis
Creators: name: Randell, Scott H.
name: Elborn, Stuart
name: Gulbins, Erich
name: Thomas, Lorraine
name: Moss, Rick
name: Banner, Katharine H.
name: Poll, Chris
name: De Jonge, Hugo
name: Growcott, Ellena
name: Rossi, Adriano G.
name: Waltz, David
name: Konstan, Mike
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: A workshop to discuss anti-inflammatory approaches in the treatment of CF was held at Novartis Institutes for Biomedical Research (NIBR, Horsham, UK) in March 2008.
Supplementary file for 'Simulations of Frustrated Ising Hamiltonians using Quantum Approximate Optimization'
Creators: name: Lotshaw, Phillip C.
name: Xu, Hanjing
name: Khalid, Bilal
name: Buchs, Gilles
name: Humble, Travis S.
name: Banerjee, Arnab
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Computational Physics
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 20603 Quantum Information, Computation and Communication
subject: FOS: Physical sciences

description: Novel magnetic materials are important for future technological advances. Theoretical and numerical calculations of ground-state properties are essential in understanding these materials, however, computational complexity limits conventional methods for studying these states. Here we investigate an alternative approach to preparing materials ground states using the quantum approximate optimization algorithm (QAOA) on near-term quantum computers. We study classical Ising spin models on unit cells of square, Shastry-Sutherland and triangular lattices, with varying field amplitudes and couplings in the material Hamiltonian. We find relationships between the theoretical QAOA success probability and the structure of the ground state, indicating that only a modest number of measurements (≲100) are needed to find the ground state of our nine-spin Hamiltonians, even for parameters leading to frustrated magnetism. We further demonstrate the approach in calculations on a trapped-ion quantum computer and succeed in recovering each ground state of the Shastry-Sutherland unit cell with probabilities close to ideal theoretical values. The results demonstrate the viability of QAOA for materials ground state preparation in the frustrated Ising limit, giving important first steps towards larger sizes and more complex Hamiltonians where quantum computational advantage may prove essential in developing a systematic understanding of novel materials.This article is part of the theme issue ‘Quantum annealing and computation: challenges and perspectives’.
Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis
Creators: name: Esther, Charles R.
name: Noone, Peadar G.
name: Kerr, Alan
name: Gilligan, Peter
name: Esserman, Denise A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Although nontuberculous mycobacteria (NTM) are recognized pathogens in cystic fibrosis (CF), associations with clinical outcomes remain unclear.
title: Finite polynomial maps and G-variant map germs.
Creators: name: Rainford. Rimmer, Christopher
Publisher: name: University of Liverpool Repository
Year: 2023

description: The first half of this thesis is devoted to the study of finite polynomial maps en --4 en and the use of Grobner bases to determine if a given map is finite. We begin by examining those maps which have quasihomogeneous components, and give a simple condition for such maps to be finite. This condition is extended to those maps which are quasihomogeneous as above, but with extra lower order terms. Next, we give a general criterion for testing the finiteness of a given polynomial map and an implementation in the Maple computer algebra system. Our next step is to generalize our results to regular maps between affine varieties. Again, a finiteness criterion is given, plus its implementation in Maple. Lastly in this half, we consider the trace bilinear form associated with a finite map and show how it may be used to find real roots of a polynomial system. The second half of the thesis is concerned with the study of G-variant map germs, which commute with the action of a finite group G on the source and target spaces. We give a relation between the G-variant degree associated with a map germ, bilinear forms on the local algebra and preimages of zero under a perturbation of the original map. We look at both the complex and real affine space situation. We then give the equivalent results when we do not have a 'good' deformation of the map, when we have two groups acting and when we use modular representations. Next, we give an invariant of G-variant maps which is stronger than G-degree, based upon a lattice of vector subspaces. Finally, we examine the structure of the class of G-variant maps and consider criteria for maps to have 'good' deformations and to be finite. We then give ways of determining generators for the class of maps by generalizing theorems of Noether and Molien.