cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring teachers’ meta-strategic knowledge of science argumentation teaching with the repertory grid technique
Creators: name: Lin, Yu-Ren
name: Hung, Cheng-Yu
name: Jeng-Fung Hung
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: This study investigated two science teachers’ meta-strategic knowledge (MSK) of argumentation teaching by applying the repertory grid technique (RGT). One teacher was a novice, while the other was experienced in teaching argumentation. Using the RGT, we elicited the objectives and strategies of the two teachers regarding their argumentation teaching involving two social scientific issue (SSI) scenarios. The results showed that the experienced teacher had more varied and organised MSK for teaching argumentation than the novice teacher. Meanwhile, the novice teacher indicated a belief that the learning of argumentation should occur in a more student-centred manner, rather than relying on a traditional lecture-based environment. Consequently, she spent a considerable amount of time engaging students with their peers’ ideas through discussion and collaboration. On the other hand, the experienced teacher noticed that most of students had the ability to generate arguments, but that few knew how to argue based on evidence. Therefore, she helped students to collect data from various resources and suggested that they construct their own knowledge framework in order to improve students’ ability to incorporate their understanding of scientific knowledge into scientific argumentation.
Additional file 10: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S7. Perkinsela sp. did not contain any X monophyly member. (PDF 237Â kb)
Does Strategic culture matter?
Creators: name: Fondrillon, Ewen
name: Link, Christine
Publisher: name: figshare
Year: 2017
Subjects: subject: 160604 Defence Studies
subject: FOS: Political science

description: A concept first appearing in the 1970s and in constant evolution, strategic culture represents the impact of cultural specificities on a country or armed force's strategic inclinations.
The aim of this paper is to determine whether or not strategic culture has an actual impact, how to understand and define such an impact, and how to use this knowledge in a strategic context.
Additional file 1: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Figure S1. SCAMK proteins mediate three calcium signal decoding pathways and the hypothesized fourth one in this research. (PDF 38Â kb)
title: The city of entertainment as an experimentation field  for improving the daily public space
Creators: name: Trabattoni, Luca
name: Capotorto, Margherita
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: Nature, Outdoor tourism, Campsite, Temporary city, Sustainability.

description: The article aims to demonstrate the value of reflection on campsite as urban laboratories. The development of the open-air tourism market has modified these settlement systems, diverting them towards integrated systems of natural and built elements. Although living on holiday represents a particular form of living, the temporality of the experience does not reduce its study value. It amplifies the market needs of citizens' desires and represents a focal case study. The accommodation facilities in the open air represent an experimental application of living in nature. The settlement system concluded in a space defined by dimensions and rules, allows a virtuous design of the open space to improve the settlement by the relationship man/nature. The aggregative space acquires a predominant value, as the basis of the anthropic landscape characterizing the accommodation itself. The reflections on the reality of outdoor tourism can be immediatly applied in a seemingly distant field: refugee camps and temporary cities. These share with the campsite the elements that make up the general structure of the settlements, renouncing the construction of the context in favour of the pragmatic nature of the intervention. The construction of the vacuum of campsite can represent an improvement revision also of emergencies.
Endoglucanase and Xylanase Production by Bacillus sp. AR03 in Co-Culture Glycosyl Hydrolases by Bacillus sp. AR03 in Co-Culture
Creators: name: Hero, Johan S
name: Pisa, José H
name: Perotti, Nora I
name: Romero, Cintia M
name: Martínez, María A
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Hematology

description: The behaviour of three isolates retrieved from different cellulolytic consortia, Bacillus sp. AR03, Paenibacillus sp. AR247 and Achromobacter sp. AR476-2, were examined individually and as co-cultures in order evaluate their ability to produce extracellular cellulases and xylanases. Utilizing a peptone-based medium supplemented with carboxymethyl cellulose (CMC), an increase estimated of 1.30 and 1.50 times was obtained by the co-culture containing the strains AR03 and AR247, with respect to enzyme titles registered by their individual cultivation. On the contrary, the extracellular enzymatic production decreased during the co-cultivation of strain AR03 with the non-cellulolytic Achromobacter sp. AR476-2. The synergistic behaviour observed through the combined cultivation of the strains AR03 and AR247 might be a consequence of the consumption by Paenibacillus sp. AR247 of the products of the CMC hydrolysis (i.e., cellobiose and/or cello- oligosaccharides), which were mostly generated by the cellulase producer Bacillus sp. AR03. The effect observed could be driven by the requirement to fulfil the nutritional supply from both strains on the substrate evaluated. These results would contribute to a better description of the degradation of the cellulose fraction of the plant cell walls in nature, expected to an efficient utilization of renewable sources.
Additional file 2: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Figure S2. The complete phylogenetic tree displaying two monophyly clusters in Fig. 2. Supporting values on the tree were produced by FastTree. Sequences from plant were shown in green, Amoebozoa in black, SAR in red, Opisthokonta in blue, and Excavata in purple. (PDF 73Â kb)
Romanian intelligence in the post cold war era
Creators: name: Fondrillon, Ewen
Publisher: name: figshare
Year: 2017
Subjects: subject: 160604 Defence Studies
subject: FOS: Political science
subject: 160510 Public Policy

description: A study of the transition of the Romanian intelligence apparatus from a cold war secret police, organ of a dictatorial regime, to an intelligence apparatus supporting a new democracy.
Additional file 3: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S3. The four insertions in the kinase domain found in Fig. 1 were shown in sequence logo format. (PDF 376Â kb)
MOESM1 of Population trends, threats, and conservation recommendations for waterbirds in China
Creators: name: Wang, Xiaodan
name: Kuang, Fenliang
name: Tan, Kun
name: Ma, Zhijun
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 1: Table S1. Population trends of migratory and resident waterbird species in China. Table S2. Population trends of waterbird species distributed exclusively on coast, inland, and both in China. Table S3. Population trends of threatened waterbird species in China. Data were classified according to residence. Table S4. Population trends of threatened waterbird species distributed exclusively on coast, inland, and both in China.
Additional file 4: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Table S1. Samples and data resources used in this research. Table S2. Characteristics of SCAMK genes. Table S3. Top 133 up-regulated genes in PF of T. brucei. Tb927.2.1820 was highlighted in green. (DOCX 450Â kb)
Supplementary information from How HLA diversity is apportioned: influence of selection and relevance to transplantation
Creators: name: Maróstica, André Silva
name: Nunes, Kelly
name: Castelli, Erick C.
name: Silva, Nayane S. B.
name: Weir, Bruce S.
name: Goudet, Jérôme
name: Meyer, Diogo
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine

description: Data sources and maps of alelle frequencies.
D6.3 – Recommendations for improving aspects of institutional publishing platforms
Creators: name: Souyioultzoglou, Irakleitos
name: Czerniak, Andreas
name: Schirrwagen, Jochen
name: Vieira, André
Publisher: name: Zenodo
Year: 2019

description: The document focuses on the standards for electronic publishing platforms, and emphasizes their
 importance in the context of Open Science as the emerging paradigm of scholarly communication.
 Based on a survey conducted from November 2018 until January 2019 and addressed to hosting
 infrastructures and operators of institutional publishing platforms and stand-alone journals, the
 document also identifies important technical aspects in electronic publishing, and provides basic
 recommendations toward the specification of common interoperability standards and their future
 implementation across institutional scientific publishing initiatives.
Effects of Intravenous Immunoglobulins on the Innate Immune Cells
Creators: name: Jandus, Peter
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/616

description:
Intravenous immunoglobulin (IVIg) is used to treat autoimmune and systemic inflammatory diseases for almost 40 years. Numerous cells are involved in the innate immune response, such as monocytes/macrophages, neutrophils, dendritic cells (DC), mast cells, basophils, eosinophils, natural killer (NK) cells, and innate lymphoid cells (ILCs). Many studies have examined the mechanisms by which IVIg down-modulates inflammation and autoimmune processes of innate immune cells. Questions still remain regarding the mechanism of action in autoimmune or inflammatory conditions. In this work, the aim was to review the immunomodulatory effect of IVIg on human innate immune cells. A narrative review approach was chosen to summarize key evidence on the immunomodulatory effects of commercially available and unmodified IVIg on humane innate immune cells. Computerized bibliographic searches of PUBMED was supplemented with a manual search of reference lists. Only English-language studies were included. 559 articles were identified in PubMed. Finally, there were 65 articles included for the current review. Four Studies were duplicated because they examined different immune cell lineages and are each listed separately with the cell lineage in question.

Thus, studies based only on animal models were not included. One study for mast cells, two for basophils, one for eosinophils, thirteen for neutrophils, eighteen for NK cells, seventeen for monocytes/macrophages, fifteen for DC and one for ILCs were included in this review. Numerous different immunomodulatory effects of IVIg were reported, with sometimes very distinct effects depending on the immune cell type and the disease. Several limitations of the different studies have been identified. Of the 64 studies reviewed, 35 (53.8%) dealt with auto- or inflammatory diseases. Otherwise, the immunomodulatory effects of IVIg have been studied only in healthy donors using an in vitro experimental approach. Some of the documented effects showed a disease-specific effects as seen in Kawasaki disease. Different methodological limitations were also discovered, which may reduce the validity of some studies. As further insights have been gained into the various inflammatory cascades activated in immunological diseases, interesting insights have also been gained into the mechanism of action of IVIg. We are still far from having discovered all the immunomodulatory mechanisms of IVIg.
Multisystem inflammatory syndrome in children related to COVID-19: What we have learned so far on this new pediatric inflammatory syndrome
Creators: name: Grazioli, Serge
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/618

description:
Since the beginning of COVID-19 pandemic, a new post-infectious inflammatory manifestation of SARS-CoV-2 affecting children has been described. It was defined as Pediatric Inflammatory Multisystem Syndrome temporally associated with COVID-19 (PIMS/PIMS-TS) by the Royal College of Pediatrics and Child Health, or as Multisystem Inflammatory Syndrome in Children (MIS-C) by the World Health Organization and the Center for Disease Control and Prevention. MIS-C represents a late manifestation of SARS-CoV-2 infection affecting predominantly previously healthy school-age children presenting with moderate to severe multi-organ dysfunction associated with an exaggerated proinflammatory response and presence of elevated SARS-CoV-2 immunoglobulin G antibodies. Although MIS-C shares similarities with Kawasaki Disease (KD), children with MIS-C tend to be older and present with a more severe proinflammatory response and myocardial injury than children with KD.

The pathophysiology of MIS-C remains largely unknown, and the current management of MIS-C is extrapolated from KD and focuses on restoring immune homeostasis with intravenous immunoglobulin, corticosteroids, and biologics as well as on the prevention of vascular complications with antiplatelet therapy and anticoagulation. Recent immunoprofile studies on MIS-C patients discovered the presence of a superantigenic-like motif on SARS-CoV-2 spike glycoprotein and an autoimmune signature targeting the various organs involved in MIS-C.

This review provides an extensive update on the state of knowledge of this new post-infectious hyperinflammatory syndrome affecting children. This topic is important for two reasons. Firstly, SARS-CoV-2 continues to infect children worldwide who may therefore still be at risk of developing MIS-C. The additional knowledge brought by this review to the clinicians may help them in the care of MIS-C patients. Secondly, a better understanding of the immunopathogenesis of MIS-C and how its immunopathological signature is distinct from acute SARS-CoV-2 infection or KD will not only be useful to guide optimal treatment in MIS-C but may also help in the management of similar hyperinflammatory conditions affecting children such as KD or haemophagocytic lymphohistiocytosis.
Additional file 5: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Figure S4. Five specific motifs found in Fig. 3 were shown in sequence logo format. (PDF 1561Â kb)
Consequences of preterm birth at school age: challenges and pathways to resilience
Creators: name: Ha-Vinh Leuchter, Russia
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/618
Prématurité
Intervention
Enfants
Adolescents
Fonctions ex

description: A considerable effort is being made to understand and prevent the short- and long-term consequences of preterm birth. However, data indicate that advances in neonatal care and increased survival have not been followed by equivalent gains in neurodevelopmental outcomes. Moreover, difficulties tend to increase over the course of children's lives, with a peak in difficulties at school age. Preterm birth not only impacts general intelligence but also executive functions and attention, which are core competencies to face the challenges of school. Socio-emotional and communication competencies and behavior are also affected, with high rates of attention deficit hyperactivity and autism spectrum disorders among these children, as well as anxiety and relational problems. Taken together, these difficulties have an important impact on academic achievements and later employment. Although there are a large number of studies on early interventions to reduce the long-term effects of prematurity, school-age interventions are still rare. To our knowledge, there is currently no systematic review that allows to synthesize the existence of such interventions and evaluate their effectiveness. We conducted both a narrative review of the literature on neurodevelopmental profile at school age after preterm birth and a qualitative systematic review on interventions for preterm school-age children and showed that very few studies with a robust design have been published so far. Yet, if based on a thorough knowledge of the developmental profile of children born prematurely, school-age interventions have the potential to target concrete difficulties experienced by this population. In turn, this might significantly help them to adapt to their immediate environment and undergo successful academic and socio-emotional experiences with a lifelong impact not only related to their integration into society and its economic aspects, but also on their global wellbeing.
THE hidden LÄND – Wir im ersten Jahrtausend
Creators: name: Redaktion, Die
Publisher: name: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege
Year: 2024

description: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege, Bd. 53 Nr. 1 (2024)
Additional file 6: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S5. Phylogenetic relationships among CaMs, CMLs, CBLs, CDPKs, and X monophyly members. (PDF 43Â kb)
Supplementary information from How human leucocyte antigen diversity is apportioned: influence of selection and relevance to transplantation
Creators: name: Maróstica, André Silva
name: Nunes, Kelly
name: Castelli, Erick C.
name: Silva, Nayane S. B.
name: Weir, Bruce S.
name: Goudet, Jérôme
name: Meyer, Diogo
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine

description: Data sources and maps of alelle frequencies.
Figure S1 from The assembly of ant-farmed gardens: mutualism specialization via host broadening
Creators: name: Chomicki, Guillaume
name: Janda, Milan
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Ant-gardens (AGs) are ant/plant mutualisms in which ants farm epiphytes in return for nest space and food rewards. They occur in the Neotropics and Australasia, but not in Africa, and their evolutionary assembly remains unclear. We here use phylogenetic frameworks for important AG lineages in Australasia, namely the ant genus Philidris and domatium-bearing ferns (Lecanopteris) and flowering plants in the Apocynaceae (Hoya and Dischidia) and Rubiaceae (Myrmecodia, Hydnophytum, Anthorrhiza, Myrmephytum and Squamellaria) to trace AG assembly in time and space. Our analyses revealed that in these clades, diaspore dispersal by ants evolved at least 13 times, five times in the Late Miocene and Pliocene in Australasia and seven times during the Pliocene in Southeast Asia, after Philidris ants had arrived there, with subsequent dispersal between these two areas. A uniquely specialized AG system evolved in Fiji at the onset of the Quaternary. The farming of other epiphytes that do not offer nest spaces in the same AGs suggests that a broadening of the ants' plant host spectrum drove the evolution of additional domatium-bearing AG-epiphytes by selecting on pre-adapted morphological traits. Consistent with this, we found a statistical correlation between the evolution of diaspore dispersal by ants and domatia in all three lineages. Our study highlights how host broadening by a symbiont has led to new farming mutualisms.
Additional file 7: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Figure S6. Scaffold of the genome released Perkinsela sp. has a most realted homolog to the X monophyly gene member CAMPEP_0174853860 from Neobodo designis. (PDF 555Â kb)
Table S2 from The assembly of ant-farmed gardens: mutualism specialization via host broadening
Creators: name: Chomicki, Guillaume
name: Janda, Milan
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Ant-gardens (AGs) are ant/plant mutualisms in which ants farm epiphytes in return for nest space and food rewards. They occur in the Neotropics and Australasia, but not in Africa, and their evolutionary assembly remains unclear. We here use phylogenetic frameworks for important AG lineages in Australasia, namely the ant genus Philidris and domatium-bearing ferns (Lecanopteris) and flowering plants in the Apocynaceae (Hoya and Dischidia) and Rubiaceae (Myrmecodia, Hydnophytum, Anthorrhiza, Myrmephytum and Squamellaria) to trace AG assembly in time and space. Our analyses revealed that in these clades, diaspore dispersal by ants evolved at least 13 times, five times in the Late Miocene and Pliocene in Australasia and seven times during the Pliocene in Southeast Asia, after Philidris ants had arrived there, with subsequent dispersal between these two areas. A uniquely specialized AG system evolved in Fiji at the onset of the Quaternary. The farming of other epiphytes that do not offer nest spaces in the same AGs suggests that a broadening of the ants' plant host spectrum drove the evolution of additional domatium-bearing AG-epiphytes by selecting on pre-adapted morphological traits. Consistent with this, we found a statistical correlation between the evolution of diaspore dispersal by ants and domatia in all three lineages. Our study highlights how host broadening by a symbiont has led to new farming mutualisms.
Additional file 8: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S8. The expression changes among two stages in the BSF cells grown for 3 days (BFD3) and 6 days (BFD6), and two stages (PF and DIF) in the PF, together with a non-tetracycline (no_Tet) induction form as the control. Two stars indicated significance at P ≤ 0.01. The raw expression data were from reported projects [43, 70]. (PDF 35 kb)
Figure S2 from The assembly of ant-farmed gardens: mutualism specialization via host broadening
Creators: name: Chomicki, Guillaume
name: Janda, Milan
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Ant-gardens (AGs) are ant/plant mutualisms in which ants farm epiphytes in return for nest space and food rewards. They occur in the Neotropics and Australasia, but not in Africa, and their evolutionary assembly remains unclear. We here use phylogenetic frameworks for important AG lineages in Australasia, namely the ant genus Philidris and domatium-bearing ferns (Lecanopteris) and flowering plants in the Apocynaceae (Hoya and Dischidia) and Rubiaceae (Myrmecodia, Hydnophytum, Anthorrhiza, Myrmephytum and Squamellaria) to trace AG assembly in time and space. Our analyses revealed that in these clades, diaspore dispersal by ants evolved at least 13 times, five times in the Late Miocene and Pliocene in Australasia and seven times during the Pliocene in Southeast Asia, after Philidris ants had arrived there, with subsequent dispersal between these two areas. A uniquely specialized AG system evolved in Fiji at the onset of the Quaternary. The farming of other epiphytes that do not offer nest spaces in the same AGs suggests that a broadening of the ants' plant host spectrum drove the evolution of additional domatium-bearing AG-epiphytes by selecting on pre-adapted morphological traits. Consistent with this, we found a statistical correlation between the evolution of diaspore dispersal by ants and domatia in all three lineages. Our study highlights how host broadening by a symbiont has led to new farming mutualisms.
Table S1 from The assembly of ant-farmed gardens: mutualism specialization via host broadening
Creators: name: Chomicki, Guillaume
name: Janda, Milan
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Ant-gardens (AGs) are ant/plant mutualisms in which ants farm epiphytes in return for nest space and food rewards. They occur in the Neotropics and Australasia, but not in Africa, and their evolutionary assembly remains unclear. We here use phylogenetic frameworks for important AG lineages in Australasia, namely the ant genus Philidris and domatium-bearing ferns (Lecanopteris) and flowering plants in the Apocynaceae (Hoya and Dischidia) and Rubiaceae (Myrmecodia, Hydnophytum, Anthorrhiza, Myrmephytum and Squamellaria) to trace AG assembly in time and space. Our analyses revealed that in these clades, diaspore dispersal by ants evolved at least 13 times, five times in the Late Miocene and Pliocene in Australasia and seven times during the Pliocene in Southeast Asia, after Philidris ants had arrived there, with subsequent dispersal between these two areas. A uniquely specialized AG system evolved in Fiji at the onset of the Quaternary. The farming of other epiphytes that do not offer nest spaces in the same AGs suggests that a broadening of the ants' plant host spectrum drove the evolution of additional domatium-bearing AG-epiphytes by selecting on pre-adapted morphological traits. Consistent with this, we found a statistical correlation between the evolution of diaspore dispersal by ants and domatia in all three lineages. Our study highlights how host broadening by a symbiont has led to new farming mutualisms.
Additional file 9: of Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling
Creators: name: Chen, Fei
name: Zhang, Liangsheng
name: Lin, Zhenguo
name: Cheng, Zong-Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Figure S9. A SCAMK-specific motif could serve as the target domain for drug design as validated by a barb scaffold molecule docking to the target domain of Tb927.2.1820 protein. (A) Phylogenetic tree showing the SCAMKs in metakinetoplastina and the SnRK1s in the Metazoa including host and vector. (B) Compared to the SnRK1s, SCAMKs have a specific calmodulin-like domain and a target domain. (C) A barb scaffold molecule was specifically docked to the target domain of Tb927.2.1820 protein with high affinity (barb molecule structure from the drug-like ligand small molecule database SwissDock. (PDF 863Â kb)
Sleep, cognition and emotion in adults and adolescents
Creators: name: Sterpenich, Virginie
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/616.8

description:
Sleep plays a key role in attention, vigilance, memory consolidation but also emotion regulation. Emotion is a collection of behaviors that allows to prioritize important information. Emotion affects a large part of cognition including memory.

In the introduction, we will summarize the main experiences demonstrating that the emotional memory traces is spontaneously replayed during sleep to enhance subsequent retention. Next, we will demonstrate that sleep loss alters the regulation of emotion and enhances stress level. Finally, we will demonstrate the link between mood disorders and sleep disturbances. Data on adults but also adolescents will be described, because this population is at a key period of development with major changes in sleep physiology, large modification of emotion reaction, and deep reorganization of brain maturation.

The aim of this thesis it to report scientific data showing the strong link between sleep, emotion and memory. The set of studies that I present attempts to understand what functional mechanisms take place during wakefulness and sleep and which brain regions play a role in emotion regulation and emotional memory. We used advanced neuroscience brain imaging techniques, including functional MRI, surface EEG and intracranial EEG in human to unravel the brain correlates at wake and during sleep.

In the first study, using fMRI, we reactivated an emotional memory trace during REM sleep with auditory cues and we observed an enhancement of the cortical responses related to these memories during subsequent retrieval. In the second study, we also reactivated emotional memory using auditory cues during a nap. Brain response was measured by intracranial electrodes implanted in epileptic patients. We showed that specific oscillations (slow oscillations and spindles) trigger the reactivation of the emotional memory trace during REM sleep particularly in the orbitofrontal cortex. In the third study, healthy participants were invited to sleep in the MRI after playing two different games that lead to a reward or not. Using a decoding approach, we observed that the rewarded game was preferentially reactivated during NREM sleep. More the game was reactivated, better were the memory performances on the next day. On the fourth study, we demonstrated that the amount of stressful dreams predict the ability to regulate emotion at wake using fMRI.

Finally, the main message of this thesis is that we need to take care of our sleep because it is much more important for our emotions and moods than we may think. Public health measures are needed to raise awareness of the importance of sleep, especially among adolescents.
The advent of minimally invasive approaches in bariatric surgery: an example of surgical revolution
Creators: name: Iranmanesh, Pouya
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/617
Bariatric surgery
Minimally invasive surgery
Robotic surgery
Laparotomy

description:
Introduction: Bariatric surgery is currently the only validated treatment option for obesity that provides significant and long-term weight loss. Even though initially performed with open techniques, the vast majority of bariatric procedures are nowadays performed using minimally invasive surgery (MIS). The objective of the present systematic review was to compare postoperative outcomes after open and MIS bariatric procedures.

Methods: A systematic search of MEDLINE, EMBASE, PUBMED, Web of Science and Cochrane databases was performed to identify studies comparing open and MIS bariatric surgery among adult patients. The primary outcome was the rate of 30-day postoperative complications. Secondary outcomes included operative times, conversion to open surgery, length of hospital stay (LOS), readmissions and reoperations.

Results: A total of 35 studies were included, reporting on 82’843 participants who underwent open and 152’398 participants who underwent MIS bariatric surgery. The overall early postoperative complication rate was 21.9% (18’175/82’843) in the open group and 18.2% (27’767/152’398) in the MIS group (p<0.0001). The rate of early severe complications was 2.4% in the open group and 1.1% in the MIS group (OR 2.17, 95% CI 1.61-2.91, p<0.0001). Rates of individual postoperative complications were all lower among MIS patients in the pooled and subgroup analyses, except for a comparable rate of hemorrhagic complications. Participants who underwent open surgery had higher mortality, reoperation and readmission rates and a longer LOS.

Conclusion: Postoperative outcomes were significantly better after MIS compared to open bariatric surgery. These findings support the use of MIS as the gold-standard for bariatric procedures.
Psychotraumatism in the context of liaison psychiatry: a scientific challenge to improve clinical care
Creators: name: Benzakour, Lamyae
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/616.89
Psychotraumatism
PTSD
Prevention
Treatment
Psychosomatic

description:
Psychotraumatisms are very frequent in the context of liaison psychiatry. The history of the concept of trauma highlights important evolution debates between clinicians, and the long time that has been needed to recognize the veracity of a traumatic event on the health. Although, trauma is historically associated to war, several medical conditions such as cancers, HIV infections, acute coronary syndrome, strokes, intensive care unit hospitalization are associated with a high rate of post-traumatic stress disorder (PTSD). These medical traumatic events have also consequences on healthcare workers that can also develop PTSD. Regarding the numerous psychiatric and physical comorbidities and the social impact of PTSD, prevention and strategies must be developed in the context of liaison psychiatry and must take account of the specificity of trauma following a medical event. In the context of liaison psychiatry, the management of somatoform symptoms constitute a big challenge. Data show that these symptoms result from previous traumas underling dissociative mechanisms. Inflammatory mechanisms appear as a key mechanism to explain physical symptoms following trauma exposure such as chronic pain, cardiometabolic disease, neurocognitive disorders, and dementia.

This thesis comprises four original publications. The first study leading on traumatic childbirth and birth-related PTSD following childbirth and the second and the fourth study leading on patients hospitalized for COVID-19 pneumonia show all the three the interest of systematic screening of risk factors to prevent PTSD. The third study highlights peritraumatic reactions and PTSD related to their work in healthcare workers during the first wave of COVID-19 pandemics. Further studies are needed to develop prevention and treatment strategies for the psychotraumatic components in the liaison psychiatry field, including systematic screening of risk factors of PTSD, early treatment such as single EMDR session following a trauma, emerging treatments such as neurofeedback or augmentation of Imagery Rehearsal Therapy with targeted Memory Reactivation. Further studies are also necessary to better understand pathophysiology somatoform dissociative disorders and somatic symptoms resulting from trauma exposure. Some data suggest inflammatory mechanisms and disrupted functional connectivity in brain are involved and that could open new strategies treatments.
Additional file 10: of InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity
Creators: name: Yang, Long
name: Gu, Wenwen
name: Cheung, King-Ho
name: Yan, Lan
name: Tong, Benjamin
name: Jiang, Yuanying
name: Yang, Jun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: Plant Biology

description: Figure S8. C. albicans-induced activation of TBK1 was independent of RalB. Representative immunoblots showing the amount of phosphorylated TBK1 (p-TBK1) in the cytosolic fraction from RAW264.7 cells at different time points of C. albicans stimulation (MOI = 10). Cells were pretreated with SEC5-shRNA, RalB-shRNA, or scramble shRNA (NC-shRNA). (DOCX 680Â kb)
Hemostasis and thrombosis in the zebrafish: a vertebrate model for human coagulopathies
Creators: name: Fish, Richard
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/576.5

description:
Upon vascular challenge, hemostasis prevents excessive bleeding. The factors in blood plasma and the vascular cells which drive blood clotting and its resolution are integral to hemostasis, but they also contribute to thrombosis, where pathological clotting leads to obstructed blood flow. The mechanism that leads to the formation and dissolution of a fibrin-rich blood clot is conserved throughout vertebrates. From jawless fish to humans, prothrombin is proteolytically activated to thrombin and this catalyzes the cleavage of fibrinogen which assembles into fibrin.

While a plethora of human diseases are linked to ineffective formation or resolution of blood clots, this thesis is focused on zebrafish models of hereditary coagulopathies, or bleeding disorders, with particular emphasis on those caused by mutations in coagulation factor genes. Hereditary coagulopathies caused by known genetic variants are considered rare diseases, but still affect hundreds of thousands of patients worldwide. Work aimed at improved understanding and treatment modalities in hemostasis remain areas of intense basic and clinical research.

The zebrafish, Danio rerio, was recently adopted as a model organism for coagulation factor deficiencies. High fecundity, transparent embryogenesis, a well-annotated genome sequence, and ease of maintenance have made it a staple for biomedical research. For hemostasis, the zebrafish embryo and larvae enable rapid in vivo assessment of blood clotting without the need for surgery, a key advantage over mammalian models.

The publications included here all concern zebrafish fibrinogen. The zebrafish fibrinogen genes were characterized, an afibrinogenemia model established, and the impact of both quantitative and qualitative changes in zebrafish fibrinogen studied, showing key pathophysiological parallels with human fibrinogen disorders. Zebrafish were also used to study the effects of drugs which change fibrinogen expression on blood clotting, and to uncover the functional importance for a conserved embryonic fibrinogen isoform.

Our work, and that of others, has highlighted the usefulness of the zebrafish for hemostasis studies. The increase in genome sequencing data and improved genome editing techniques will now allow us to generate more focused zebrafish models of genomic variants implicated in diseases of hemostasis and thrombosis.
Beyond specific effects of vaccines
Creators: name: Pittet, Laure
Publisher: name: Université de Genève
Year: 2023
Subjects: info:eu-repo/classification/ddc/618
Vaccine
Off-target effects of vaccines
Non-specific effects of vaccine
Cross-protection
BCG
Bacille Calmette-Guérin
Vaccination
Scar
Adverse reaction
Immunogenicity
Vaccine responses
Vaccine hesitancy
Herd immunity

description: Whereas the paradigm of vaccine is to provide protection of the vaccinee against the targeted disease (the specific effect of vaccine), many other effects may emanate from vaccination. These include: populational protection acquired through induction of herd immunity; individual protection of nonvaccinated persons acquired through third-party strategies such as maternal, toddler and caregiver immunisation; cross-protective effects against closely related pathogen; downstream effects by indirectly protecting against diseases that would have been predisposed by the prevented infection; adverse effects, that may also indirectly inform on vaccine responses or on the vaccinee’s underlying immunity; and non-specific effects. The study of non-specific effects of vaccines is a research topic of growing importance in vaccinology. Non-specific effects of vaccines are proposed to explain observations that certain vaccines can provide “unplanned” benefits against unrelated infections, allergic diseases, autoimmune diseases, and malignancies, through the induction of broader changes to immune cells, and therefore have an impact beyond the protection against the specific pathogens for which the vaccines were designed. In this Privat Docent thesis I have tried to illustrate these different facets of vaccination with some of the papers I have published in the past three years. After a general introduction setting up the context, the publications are introduced sequentially, followed by a general discussion giving future perspectives.
Entdeckungen aus den Archiven
Creators: name: Koltermann, Grit
Publisher: name: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege
Year: 2024

description: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege, Bd. 53 Nr. 1 (2024)
Von Strumpfhosen und Seifenblasen
Creators: name: Liebl, Andreas
Publisher: name: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege
Year: 2024

description: Denkmalpflege in Baden-Württemberg – Nachrichtenblatt der Landesdenkmalpflege, Bd. 53 Nr. 1 (2024)
Table S5 from The assembly of ant-farmed gardens: mutualism specialization via host broadening
Creators: name: Chomicki, Guillaume
name: Janda, Milan
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Ant-gardens (AGs) are ant/plant mutualisms in which ants farm epiphytes in return for nest space and food rewards. They occur in the Neotropics and Australasia, but not in Africa, and their evolutionary assembly remains unclear. We here use phylogenetic frameworks for important AG lineages in Australasia, namely the ant genus Philidris and domatium-bearing ferns (Lecanopteris) and flowering plants in the Apocynaceae (Hoya and Dischidia) and Rubiaceae (Myrmecodia, Hydnophytum, Anthorrhiza, Myrmephytum and Squamellaria) to trace AG assembly in time and space. Our analyses revealed that in these clades, diaspore dispersal by ants evolved at least 13 times, five times in the Late Miocene and Pliocene in Australasia and seven times during the Pliocene in Southeast Asia, after Philidris ants had arrived there, with subsequent dispersal between these two areas. A uniquely specialized AG system evolved in Fiji at the onset of the Quaternary. The farming of other epiphytes that do not offer nest spaces in the same AGs suggests that a broadening of the ants' plant host spectrum drove the evolution of additional domatium-bearing AG-epiphytes by selecting on pre-adapted morphological traits. Consistent with this, we found a statistical correlation between the evolution of diaspore dispersal by ants and domatia in all three lineages. Our study highlights how host broadening by a symbiont has led to new farming mutualisms.