cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Oral exposure to aluminum leads to reduced nicotinic acetylcholine receptor gene expression, severe neurodegeneration and impaired hippocampus dependent learning in mice
Creators: name: Farhat, Syeda Mehpara
name: Aamra Mahboob
name: Touqeer Ahmed
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Aluminum (Al) is known for its neurotoxicity for over a century and is reported to have specifically high toxicity for cholinergic system. The effect of Al on muscarinic acetylcholine receptors is widely reported, but its effect on nicotinic acetylcholine receptors (nAChRs) is less well known. The aim of this study was to determine the effects of Al on hippocampus dependent learning and memory, function and expression of nAChRs in the hippocampus. Al concentration and neurodegeneration were also measured in the hippocampus following Al treatment. The mice were treated with 250 mg/kg AlCl3.6H2O in drinking water for a period of 42 days. Results show that Al treated animals have significantly reduced spatial reference memory as compared to control animals in Morris water maze test. Similarly, Al treated animals showed reduced contextual memory for Pavlovian fear compared to control animals. Al treated animals show higher anxiety in elevated plus maze as compared to control animals. The analysis of nAChR expression via RT-PCR showed reduced expression of α7, α4 and β2 nAChR gene expression in the hippocampus of Al treated animals. High Al accumulation was observed in Al-treated animals (688.14 ± 242.82 μg/g) compared to the control group (115.14 ± 18.18 μg/g) that resulted in severe neurodegeneration in the hippocampus. These results demonstrated that Al exposure caused neurotoxicity in mice hippocampus which is manifested by reduced memory and elevated anxiety. The results were further validated by high Al accumulation in the hippocampus, severe neurodegeneration and reduced expression of nAChRs.
Bourletiella (Bourletiella) viridescens Stach, 1920 sensu Gisin 1948
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Bourletiellidae
Bourletiella
Bourletiella viridescens

description: Bourletiella (Bourletiella) viridescens Stach, 1920 sensu Gisin 1948
Bourletiella signata var. viridescens Stach, 1920: 199.
Bourletiella lutea Gisin, 1946a: 258.
Bourletiella viridescens – Gisin 1948b: 502.
Bourletiellahortensis – Stach 1956: 149.
Bourletiella (Bourletiella) viridescens – Bretfeld 1999: 231.
DISTRIBUTION. — Ariège. Vers Lordat, 1240 m (Nayrolles 1995a).
Aveyron. Prairies Caussedel’Aveyron (Raynal 1973). — La-Bastide- Solages, entre Plaisance et Brase (Nayrolles 1995a).
Corse. Ucciani (Denis 1947b, B. lutea).
Côte-d’Or. Saint-Jean-de-Losne (Jeannenot 1954, B. lutea).
Essonne. Forêtde Sénart (Ponge 1980, 1993).
Hautes-Pyrénées. Valléed’Aure (Cassagnau 1964a, B. hortensis; 1964c). — Valléed’Aure (Raynal 1973).
Meurthe-et-Moselle. Lorraine (Picard 1962, B. lutea).
TAXONOMIE. — Jeannenot 1954 (redescription); Nayrolles 1995a.
ÉCOLOGIE. — Picard 1962 (faune psammique); Cassagnau 1964c; Ponge 1980, 1993.
COMPORTEMENT. — Raynal 1973 (comportement reproducteur).
Bourletiella (Cassagnaudiella) canigouensis
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 399, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Shape Deformation and Drag Variation of a Coupled Rigid-flexible System in a Flowing Soap Film
Creators: name: Gao, Song
name: Pan, Song
name: Wang, Huaicheng
name: Tian, Xinliang
Publisher: name: arXiv
Year: 2020
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We experimentally study the flow past a rigid plate with an attached closed filament acting as a deformable afterbody in the soap film. The complex fluid-structure interactions due to its deformable shape and corresponding dynamics are studied. We find the shape of the afterbody is determined by the filament length and flow velocity. A significant drag reduction of up to 9.0% is achieved by adjusting the filament length. We analyze the drag mechanism by characterizing the deformable afterbody shape and wake properties. Our experiment and modeling suggest that such favorable flow control and drag reduction are expected to occur over a specific flow speed regime when the flexible afterbody is suitably added.
The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR
Creators: name: Kalveram, Laura
name: Kleinau, Gunnar
name: Szymańska, Kamila
name: Scheerer, Patrick
name: Rivero-Müller, Adolfo
name: Grüters-Kieslich, Annette
name: Biebermann, Heike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: central congenital hypothyroidism
subject: G-protein coupled receptors
subject: thyroid-stimulating hormone
subject: TSHR
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: 1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB). The TSHB mutation C105Vfs114X leads to isolated thyroid-stimulating-hormone-(TSH)-deficiency and results in a severe phenotype. The aim of this study was to gain more insight into the underlying molecular mechanism and the functional effects of this mutation based on two assumptions: a) the three-dimensional (3D) structure of TSH should be modified with the C105V substitution, and/or b) whether the C-terminal modifications lead to signaling differences. 2) Methods: wild-type (WT) and different mutants of hTSH were generated in human embryonic kidney 293 cells (HEK293 cells) and TSH preparations were used to stimulate thyrotropin receptor (TSHR) stably transfected into follicular thyroid cancer cells (FTC133-TSHR cells) and transiently transfected into HEK293 cells. Functional characterization was performed by determination of Gs, mitogen activated protein kinase (MAPK) and Gq/11 activation. 3) Results: The patient mutation C105Vfs114X and further designed TSH mutants diminished cyclic adenosine monophosphate (cAMP) signaling activity. Surprisingly, MAPK signaling for all mutants was comparable to WT, while none of the mutants induced PLC activation. 4) Conclusion: We characterized the patient mutation C105Vfs114X concerning different signaling pathways. We identified a strong decrease of cAMP signaling induction and speculate that this could, in combination with diverse signaling regarding the other pathways, accounting for the patient's severe phenotype.
Cheumatopsyche villosa
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche villosa

description: Cheumatopsyche villosa (Navás, 1934)
 Hydropsychodes villosa Navás, 1934a: 22.
 Cheumatopsyche villosa (Navás, 1934); Kimmins 1963: 130.
 Type locality: “Africa”.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 161
Housing situation and healthcare for patients in a psychiatric centre in Berlin, Germany: a cross-sectional patient survey
Creators: name: Schreiter, Stefanie
name: Heidrich, Sascha
name: Zulauf, Jamie
name: Saathoff, Ute
name: Brückner, Anne
name: Majic, Tomislav
name: Rössler, Wulf
name: Schouler-Ocak, Meryam
name: Krausz, Michael R.
name: Bermpohl, Felix
name: Bäuml, Josef
name: Gutwinski, Stefan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: adult psychiatry
subject: epidemiology
subject: mental health
subject: quality in healthcare
subject: substance misuse
subject: schizophrenia and psychotic disorders
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: OBJECTIVE: To determine the housing situation among people seeking psychiatric treatment in relation to morbidity and service utilisation. DESIGN: Cross-sectional patient survey. SETTING: Psychiatric centre with a defined catchment area in Berlin, Germany, March-September 2016. PARTICIPANTS: 540 psychiatric inpatients including day clinics (43.2% of all admitted patients in the study period (n=1251)). MAIN OUTCOME MEASURES: Housing status 30 days prior the interview as well as influencing variables including service use, psychiatric morbidity and sociodemographic variables. RESULTS: In our survey, 327 participants (68.7%) currently rented or owned an own apartment; 62 (13.0%) reported to be homeless (living on the street or in shelters for homeless or refugees); 87 (18.3%) were accommodated in sociotherapeutic facilities. Participants without an own apartment were more likely to be male and younger and to have a lower level of education. Homeless participants were diagnosed with a substance use disorder significantly more often (74.2%). Psychotic disorders were the highest among homeless participants (29.0%). Concerning service use, we did neither find a lower utilisation of ambulatory services nor a higher utilisation of hospital-based care among homeless participants. CONCLUSIONS: Our findings underline the need for effective housing for people with mental illness. Despite many sociotherapeutic facilities, a concerning number of people with mental illness is living in homelessness. Especially early interventions addressing substance use might prevent future homelessness.
Enhanced transmission versus localization of a light pulse by a subwavelength metal slit: Can the pulse have both characteristics?
Creators: name: Kukhlevsky, S. V.
name: Mechler, M.
name: Csapo, L.
name: Janssens, K.
name: Samek, O.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The existence of resonant enhanced transmission and collimation of light waves by subwavelength slits in metal films [for example, see T.W. Ebbesen et al., Nature (London) 391, 667 (1998) and H.J. Lezec et al., Science, 297, 820 (2002)] leads to the basic question: Can a light be enhanced and simultaneously localized in space and time by a subwavelength slit? To address this question, the spatial distribution of the energy flux of an ultrashort (femtosecond) wave-packet diffracted by a subwavelength (nanometer-size) slit was analyzed by using the conventional approach based on the Neerhoff and Mur solution of Maxwell's equations. The results show that a light can be enhanced by orders of magnitude and simultaneously localized in the near-field diffraction zone at the nm- and fs-scales. Possible applications in nanophotonics are discussed.
description: 5 figures
Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period
Creators: name: Glimm, Anne-Marie
name: Sprenger, Lisa Ines
name: Haugen, Ida Kristin
name: Mansmann, Ulrich
name: Hermann, Sandra
name: Häupl, Thomas
name: Hoff, Paula
name: Burmester, Gerd-Rüdiger
name: Backhaus, Marina
name: Le, Lien
name: Ohrndorf, Sarah
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Arthritis
subject: rheumatoid
subject: Fluorescence
subject: Ultrasonography
subject: Follow-up studies
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. OBJECTIVE: To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration 3.2) RA over a period of 12 months. METHODS: Thirty-five RA patients (24 (68.6%) females, mean age 53.3 years (SD 13.6)) were investigated clinically by DAS28, tender joint count (TJC) and swollen joint count (SJC) and by FOI in phases 1-3 and PrimaVistaMode (PVM) before therapy change and after 12 months. The FOI activity score (FOIAS) was calculated based on individual joint scores from 0 to 3 in 30 joints per patient, adding up to a sum score (0-90). RESULTS: We found a statistically significant reduction of FOIAS in phase 1 from baseline (median 5.0, IQR 24.96) to follow-up (median 1.0, IQR 4.0) in all patients (p = 0.0045), both in responders and non-responders according to EULAR response criteria by DAS28. Statistically significant reductions over 12 months were found for median DAS28(ESR) 5.61 to 3.31, TJC 7.0 to 1.0, and SJC 5.0 to 1.0 (each p
Cheumatopsyche sauteri Navas 1933
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche sauteri

description: Cheumatopsyche sauteri Navás, 1933
 Cheumatopsyche sauteri Navás, 1933: 99.
 Type locality: Taiwan.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 161
Set Membership identification of linear systems with guaranteed simulation accuracy
Creators: name: Lauricella, Marco
name: Fagiano, Lorenzo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: The problem of model identification for linear systems is considered, using a finite set of sampled data affected by a bounded measurement noise, with unknown bound. The objective is to identify one-step-ahead models and their accuracy in terms of worst-case simulation error bounds. To do so, the Set Membership identification framework is exploited. Theoretical results are derived, allowing one to estimate the noise bound and system decay rate. Then, these quantities and the data are employed to define the Feasible Parameter Set (FPS), which contains all possible models compatible with the available information. Here, the estimated decay rate is used to refine the standard FPS formulation, by adding constraints that enforce the desired converging behavior of the models' impulse response. Moreover, guaranteed simulation error bounds for an infinite future horizon are derived, improving over recent results pertaining to finite simulation horizon only. These bounds are the basis for a result and method to guarantee asymptotic stability of the identified model. Finally, the desired one-step-ahead model is identified by means of numerical optimization, and the related simulation error bounds are evaluated. Both input-output and state-space model structures are addressed. The approach is showcased on a numerical example and on real-world experimental data of the roll rate dynamics of an autonomous glider.
description: This is a preprint of an article published on the IEEE Transactions on Automatic Control
Forward-reserve storage strategies with order picking: When do they pay off?
Creators: name: Wu, Wan
name: Koster, René B.M. De
name: Yugang Yu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: Customer order response time and system throughput capacity are key performance measures in warehouses. They depend strongly on the storage strategies deployed. One popular strategy is to split inventory into a bulk storage and a pick stock, or Forward-Reserve (FR) storage. Managers often use a rule of thumb: when the ratio m of average picks per replenishment is larger than a certain factor, it is beneficial to split inventory. However, research that systematically quantifies the benefits is lacking. We quantify the benefits analytically by developing response travel time models for FR storage in an Automated Storage/Retrieval system combined with order picking. We compare performance of FR storage with turnover class-based storage, and find when it pays off. Our findings illustrate that, in FR storage systems where forward and reserve stocks are stored in the same rack, FR storage usually pays off, as long as m is sufficiently larger than 1. The response time savings can go up to 50% when m is larger than 10. We validate these results using real data from a wholesale distributor.
Suppressed charge recombination in hematite photoanode via protonation and annealing
Creators: name: Si, Wenping
name: Haydous, Fatima
name: Babic, Ugljesa
name: Pergolesi, Daniele
name: Lippert, Thomas
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Hematite as promising photoanode for solar water splitting suffers from severe bulk and surface charge recombination. This work describes that a protonation-annealing treatment can effectively suppress both bulk and surface charge recombination in hematite. Protons/electrons are electrochemically incorporated into hematite under 0.2 VRHE followed by annealing at 120 oC. The photocurrent density increases from ~0.9 mA cm-2 to 1.8 mA cm-2 at 1.23 VRHE under 1 sun, and further to 2.7 mA cm-2 after loading cobalt phosphate, stabilizing at round 2.4 mA cm-2. A cathodic shift of the onset potential of photocurrent is also observed. H2O2 oxidation, impedance spectroscopy and Mott-Schottky measurements show that the protonation suppresses bulk recombination and enhances donor density, but introducing more surface recombination. The annealing reduces surface recombination, while preserving relatively high bulk charge separation efficiency. Different from previous reports on the electrochemically reduced hematite, this work demonstrates that the performance improvement should be ascribed to the proton incorporation instead of the formation of Fe3O4 or metal Fe. This facile treatment by protonation and annealing could be applied in other semiconductors to promote the development of high performing photoelectrodes.
Investigation of the mucoadhesivity, swelling, and drug release mechanisms of indomethacin buccal tablets: effect of formulation variables
Creators: name: Ozgur Esim
name: Savaser, Ayhan
name: Ozkan, Cansel Kose
name: Cetin Tas
name: Yalcın Ozkan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: The purpose of this study was to investigate the effect of formulation variables on properties related to critical functionality for their use in indomethacin buccal tablets. Chitosan (CH), carbopol (PAA), and hydroxypropyl methyl cellulose (HPMC) concentration and filler type were evaluated as parameters for describing tablet hardness, swelling index, indomethacin release, and mucoadhesion in controlled release buccal tablets. Moreover, a 32 full factorial design was employed to study the effect of each polymer ratio in CH and PAA combination, which significantly influenced characteristics. A slower indomethacin release and a considerably larger degree of swelling were found for different concentrations of PAA or CH (p In vitro drug release in simulated saliva (pH 6.75) appears to occur both by diffusion and a swelling-controlled mechanism, exhibiting anomalous, Case II type transport or Super Case II type transport. The diluent present in all study samples, mannitol (MAN), spray-dried lactose (SDL), and microcrystalline cellulose (MC) were believed to contribute minimally to hydrogel formation and drug release regulation. The dissolution values for the three co-excipients were decreasing order mannitol, spray-dried lactose, and microcrystalline cellulose. In conclusion, the type and concentration of all polymers seem to change the functionality of buccal tablets and it seems important to understand and characterize these excipients to fully predict the drug release, mucoadhesion, and swelling of buccal tablets.
Deuterosminthurus bicinctus sensu Stach 1956
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Bourletiellidae
Deuterosminthurus
Deuterosminthurus bicinctus

description: Deuterosminthurus bicinctus (Koch, 1840) sensu Stach 1956 *
Sminthurus bicinctus Koch, 1840: 353.
Bourletiella (Deuterosminthurus) flava Gisin, 1946a: 254.
Deuterosminthurus bicinctus – Stach 1956: 171.
DISTRIBUTION. — Essonne. Forêt de Sénart et parc du Laboratoire du MNHNà Brunoy (Vannier 1970, D. flavus; Ponge 1973, 1980, 1993; Betsch 1991).
Gers. Vers Cravencères (Nayrolles 1996).
Haute-Garonne. Toulouse (Cassagnau 1962a).
Haute-Saône. Denis 1924d.
Hautes-Pyrénées. Valléed’Aure (Cassagnau 1964a, c, D. flavus).
Meurthe-et-Moselle. Picard 1962.
Tarn, Aude. Montagne Noire (Cassagnau 1965).
Tarn. Entre Lacabarède et Rouairoux, 440 m (Nayrolles 1996).
TAXONOMIE. — Nayrolles 1996 (redescription).
ÉCOLOGIE. — Picard 1962 (faune psammique); Cassagnau 1964c, 1965 (écologie, sol); Vannier 1970 (eau, sol); Ponge 1973, 1980, 1993; Betsch 1991 (privation delitière).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 400, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Clinical Characteristics of Inpatients with Childhood vs. Adolescent Anorexia Nervosa
Creators: name: Jaite, Charlotte
name: Bühren, Katharina
name: Dahmen, Brigitte
name: Dempfle, Astrid
name: Becker, Katja
name: Correll, Christoph U.
name: Egberts, Karin M.
name: Ehrlich, Stefan
name: Fleischhaker, Christian
name: Gontard, Alexander Von
name: Hahn, Freia
name: Kolar, David
name: Kaess, Michael
name: Legenbauer, Tanja
name: Renner, Tobias J.
name: Schulze, Ulrike
name: Sinzig, Judith
name: Thomae, Ellen
name: Weber, Linda
name: Wessing, Ida
name: Antony, Gisela
name: Hebebrand, Johannes
name: Föcker, Manuel
name: Herpertz-Dahlmann, Beate
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: anorexia nervosa
subject: children
subject: adolescents
subject: clinical characteristics
subject: BMI
subject: outcome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: We aimed to compare the clinical data at first presentation to inpatient treatment of children (<14 years) vs. adolescents (≥14 years) with anorexia nervosa (AN), focusing on duration of illness before hospital admission and body mass index (BMI) at admission and discharge, proven predictors of the outcomes of adolescent AN. Clinical data at first admission and at discharge in 289 inpatients with AN (children: n = 72; adolescents: n = 217) from a German multicenter, web-based registry for consecutively enrolled patients with childhood and adolescent AN were analyzed. Inclusion criteria were a maximum age of 18 years, first inpatient treatment due to AN, and a BMI <10th BMI percentile at admission. Compared to adolescents, children with AN had a shorter duration of illness before admission (median: 6.0 months vs. 8.0 months, p = 0.004) and higher BMI percentiles at admission (median: 0.7 vs. 0.2, p = 0.004) as well as at discharge (median: 19.3 vs. 15.1, p = 0.011). Thus, in our study, children with AN exhibited clinical characteristics that have been associated with better outcomes, including higher admission and discharge BMI percentile. Future studies should examine whether these factors are actually associated with positive long-term outcomes in children.
The Prognostic Effect of Circadian Blood Pressure Pattern on Long-Term Cardiovascular Outcome is Independent of Left Ventricular Remodeling
Creators: name: Tadic, Marijana
name: Cuspidi, Cesare
name: Celic, Vera
name: Pencic, Biljana
name: Mancia, Giuseppe
name: Grassi, Guido
name: Stankovic, Goran
name: Ivanovic, Branislava
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: hypertension
subject: left ventricle
subject: hypertrophy
subject: diastolic dysfunction
subject: non-dipping
subject: reverse dipping
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: We aimed to investigate the predictive value of 24 h blood pressure (BP) patterns on adverse cardiovascular (CV) outcome in the initially untreated hypertensive patients during long-term follow-up. This study included 533 initially untreated hypertensive patients who were involved in this study in the period between 2007 and 2012. All participants underwent laboratory analysis, 24 h BP monitoring, and echocardiographic examination at baseline. The patients were followed for a median period of nine years. The adverse outcome was defined as the hospitalization due to CV events (atrial fibrillation, myocardial infarction, myocardial revascularization, heart failure, stroke, or CV death). During the nine-year follow-up period, adverse CV events occurred in 85 hypertensive patients. Nighttime SBP, non-dipping BP pattern, LV hypertrophy (LVH), left atrial enlargement (LAE), and LV diastolic dysfunction (LV DD) were risk factors for occurrence of CV events. However, nighttime SBP, non-dipping BP pattern, LVH, and LV DD were the only independent predictors of CV events. When all four BP pattern were included in the model, non-dipping and reverse dipping BP patterns were associated with CV events, but only reverse-dipping BP pattern was independent predictor of CV events. The current study showed that reverse-dipping BP pattern was predictor of adverse CV events independently of nighttime SBP and LV remodeling during long-term follow-up. The assessment of BP patterns has very important role in the long-time prediction in hypertensive population.
A second-order exponential time differencing scheme for non-linear reaction-diffusion systems with dimensional splitting
Creators: name: Asante-Asamani, E. O.
name: Kleefeld, A.
name: Wade, B. A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65M12, 65M15, 65M20, 65F60

description: A second-order $L$-stable exponential time-differencing (ETD) method is developed by combining an ETD scheme with approximating the matrix exponentials by rational functions having real distinct poles (RDP), together with a dimensional splitting integrating factor technique. A variety of non-linear reaction-diffusion equations in two and three dimensions with either Dirichlet, Neumann, or periodic boundary conditions are solved with this scheme and shown to outperform a variety of other second-order implicit-explicit schemes. An additional performance boost is gained through further use of basic parallelization techniques.
description: 28 pages, 9 figures
Research Models for Studying Vascular Calcification
Creators: name: Herrmann, Jaqueline
name: Babic, Milen
name: Tölle, Markus
name: Giet, Markus Van Der
name: Schuchardt, Mirjam
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: vascular calcification
subject: in vitro
subject: ex vivo
subject: in vivo
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process. The exact underlying mechanisms are not fully elucidated and reliable treatment options are lacking. Due to the complex pathophysiology, various research models exist evaluating different aspects of VC. This review aims to give an overview of the cell and animal models used so far to study the molecular processes of VC. Here, in vitro cell culture models of different origins, ex vivo settings using aortic tissue and various in vivo disease-induced animal models are summarized. They reflect different aspects and depict the (patho)physiologic mechanisms within the VC process.
Solubility determination and solution thermodynamics of olmesartan medoxomil in (PEG-400 + water) cosolvent mixtures
Creators: name: Al-Shdefat, Ramadan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Hematology

description: The solubility and solution thermodynamic properties of a weakly water-soluble compound olmesartan medoxomil (OLM) in binary ‘polyethylene glycol (PEG-400) + water’ cosolvent compositions were determined. The ‘mole fraction solubility (xe)’ of OLM in binary ‘PEG-400 + water’ cosolvent compositions and pure solvents (PEG-400 and water) was determined at ‘T = 295.15-330.15 K’ and ‘p = 0.1 MPa’. The Hansen solubility parameter (HSP) of OLM, pure PEG-400, pure water, and binary ‘PEG-400 + water’ cosolvent compositions free of OLM were also predicted. The obtained xe values of OLM were correlated using ‘van’t Hoff, modified Apelblat, Yalkowsky-Roseman, Jouyban-Acree and Jouyban-Acree-van’t Hoff’ computational models with the error values of <4.0%. The maximum and minimum xe value of OLM was predicted in neat PEG-400 (1.15 × 10−2 at T = 330.15 K) and neat water (1.90 × 10−7 at T = 295.15 K), respectively. The OLM HSP was predicted to be more close with that of neat PEG-400. The xe value of OLM was found increased significantly with increase in temperature and PEG-400 mass fraction in all ‘PEG-400 + water’ cosolvent compositions including neat PEG-400 and neat water. An ‘apparent thermodynamic analysis’ studies presented an ‘endothermic and entropy-driven dissolution’ of OLM in all ‘PEG-400 + water’ cosolvent compositions including pure PEG-400 and pure water.
Deuterosminthurus maculatus Nayrolles 1996
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Bourletiellidae
Deuterosminthurus
Deuterosminthurus maculatus

description: Deuterosminthurus maculatus Nayrolles, 1996
Deuterosminthurus maculatus Nayrolles, 1996: 543.
DISTRIBUTION. — Aude. Route entre Valmigère et Arques, 680 m, prèsde Valmigère (Nayrolles 1996).
Aveyron. Gages au Causse Comtal, 620 m, vers Montrozier et plateau de la Justice près de Bessuéjouls (Nayrolles 1996).
Haute-Garonne. Vers Roquefort-sur-Garonne, 270 m (Nayrolles 1996).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 400, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Forward-Reserve Storage Strategies with Order Picking: When Do They Pay Off?
Creators: name: Wu, Wan
name: Koster, René B.M. De
name: Yugang Yu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: Customer order response time and system throughput capacity are key performance measures in warehouses, which depend strongly on the storage strategies deployed. One popular strategy is to split inventory into a bulk storage and a pick stock, or forward-reserve (FR) storage. Managers often use a rule of thumb: when the ratio m of average picks per replenishment is larger than a certain factor, it is beneficial to split inventory. However, research that systematically quantifies the benefits is lacking. We quantify the benefits analytically by developing response travel time models for FR storage in an Automated Storage/Retrieval system combined with order picking. We compare performance of FR storage with turnover class-based storage, and find when it pays off. Our findings illustrate that, in FR storage systems where forward and reserve stocks are stored in the same rack, FR storage usually pays off, as long as m is sufficiently larger than 1. The response time savings can go up to 50 % when m is larger than 10. We validate these results using real data from a wholesale distributor.
Helluodes westwoodi Chaudoir 1869
Creators: name: Sabu, Thomas K.
name: Abhitha, Prabhakar
name: Zhao, Danyang
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Helluodes
Helluodes westwoodi

description: Helluodes westwoodi Chaudoir, 1869
(Figs. 12–14)
 Helluodes westwoodi Chaudoir, 1869: 203.
 Head. Labrum very large, as wide as long, anterior margin distinctly emarginated in the middle, with a row of 6 marginal setae. Maxillary palpomere 4 flattened, short, inflexed medially and internal surface with distinct, deep puncture; roundly expanded from basal one third, roundly narrowed at apex. Mentum with bifid median tooth. Ligula elongate, setose with four elongated apical setae, three lateral seta on either side; distinctly broader in the middle.
 Pronotum. Large and slightly wider than head; less densely pubescent and sparsely punctate on disc; apical angles protruded, expanded, flexed inwardly, more rounded and slightly acute on summit; anterior and posterior transverse sulci shallow; lateral margins widely explanate, distinctly sinuated anterior to posterior angles or at some distance from base; posterior angles expanded, reflexed strongly and sharp at apex; basal foveae deep and wide, stretching forward as deep lateral furrows; base narrower than apex, distinctly oblique laterally, weakly sinuated medially.
 Elytra. Apices obliquely truncate with wide membranous margins; outer angles sinuate; elytra with intervals sparsely punctate and pubescent, lateral edges broad.
 Legs. Short, front tibiae emarginated at apex.
 Venter. Punctate-pubescent except the glabrous posterior area of prosternum. Sternites 3 to 6 in male and female with one pair of paramedian setae.
 Genitalia. As for genus.
 Measurements. Male (n=2), TLA = 26.5 and 27.5; TLB = 24.0 and 25.0; TW = 8.5 and 10.0; PL = 3.0 and 4.0; PW = 6.0 and 7.0; EL = 14.0 and 15.0. Female (n=2), TLA = 25.0 and 26.0; TLB = 22.0 and 23.0; TW = 9.0; PL = 3.2; PW = 5.5; EL = 14.0 and 14.5.
 Specimens examined (n=4). Male labeled “Ex-Musaeo Chaudoir” / “westwoodii Chaud. Deccan, S. Stevens ” (designated as Lectotype in the present work); 1 female with the same label as that of Lectotype, and 1 male and 1 female labeled “ Ceylon ”. All specimens are in the Chaudoir collections of MNHN.
 Distribution. South India (Deccan), Sri Lanka (exact locality in both regions unknown).
 Remarks. Distinct from other two species with distinctly emarginate labrum; ligula broader in the middle; pronotum with rounded but slightly acute anterior angles, raised lateral margins with distinct sinuation anterior to posterior angles.
description: Published as part of Sabu, Thomas K., Abhitha, Prabhakar & Zhao, Danyang, 2008, A new Helluodes Westwood species from Western Ghats with notes on habitat, distribution and phylogenetic relationships of genera Helluodes Westwood and Physocrotaphus Parry of the tribe Physocrotaphini Chaudoir (Insecta: Coleoptera: Carabidae: Anthiinae), pp. 30-46 in Zootaxa 1745 (1) on pages 35-36, DOI: 10.11646/zootaxa.1745.1.3, http://zenodo.org/record/5108342
SERVANT LEADERSHIP, MOTIVATION AND MORAL HAZARD
Creators: name: YUNINA RESMI PRANANTA
name: S MARTONO
name: SUWITO EKO PRAMONO
name: ARIEF YULIANTO
Publisher: name: Zenodo
Year: 2024
Subjects: Moral Hazard, Motivation, Indonesian Education, Servant Leadership.

description: Abstract

This research aims to investigate the impact of servant leadership and motivation on the level of moral hazard in the work environment. In the context of education in Indonesia, especially in the teaching sector, this phenomenon is connected with stewardship theory. Even though Eastern culture emphasizes employee obedience to superiors, there is still moral hazard behaviour among teachers. This study attempts to provide an in-depth understanding of how servant leadership and motivation can be used to reduce the risk of moral hazard. The research method used was quantitative, involving 400 teachers in Wonosobo Regency. The results of the analysis show that servant leadership and motivation positively and significantly influence moral hazard. Servant leadership, with its focus on service, creates an ethical and responsible work environment, while motivation acts as a protective factor, reducing unethical behaviour or fraud. From the perspective of agency theory, it is explained that the conflict of interest between the agent (teacher) and the principal (principal school) raises the problem of moral hazard. Teachers tend to carry out moral hazard actions because of extrinsic and intrinsic incentives, as well as the responsibility placed on the school principal. In conclusion, this research makes an important contribution to understanding and handling the risk of moral hazard in the educational context in Indonesia by emphasizing the positive role of servant leadership and motivation as a solution to creating an ethical and responsible work environment. This is relevant in improving the quality of learning, academic achievement and the integrity of the education system as a whole.
Supersoft X-ray Sources in M31: I. A Chandra Survey and an Extension to Quasisoft Sources
Creators: name: Di Stefano, R.
name: Kong, A. K. H.
name: Greiner, J.
name: Primini, F. A.
name: Garcia, M. R.
name: Barmby, P.
name: Massey, P.
name: Hodge, P. W.
name: Williams, B. F.
name: Murrary, S. S.
name: Curry, S.
name: Russo, T. A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on very soft X-ray sources (VSSs) in M31. In a survey which was most sensitive to soft sources in four 8'x8' regions covered by Chandra's ACIS-S S3 CCD, we find 33 VSSs that appear to belong to M31. Fifteen VSSs have spectral characteristics mirroring the supersoft X-ray sources studied in the Magellanic Cloud and Milky Way ($k T_{eff} \leq 100$ eV); we therefore call these ``classical'' supersoft sources, or simply supersoft sources (SSSs). Eighteen VSSs may either have small (< 10%) hard components, or slightly higher effective temperatures (but still < 350 eV). We refer to these VSSs as quasisoft sources (QSSs). While hot white dwarf models may apply to SSSs, the effective temperatures of QSSs are too high, unless, e.g., the radiation emanates from only a small portion of surface. Two of the SSSs were first detected and identified as such through ROSAT observations. One SSS and one QSS may be identified with symbiotics, and 2 SSSs with supernova remnants. Both SSSs and QSSs in the disk are found near star-forming regions, possibly indicating that they are young. VSSs in the outer disk and halo are likely to be old systems; in these regions, there are more QSSs than SSSs, which is opposite to what is found in fields closer to the galaxy center. The largest density of bright VSSs is in the bulge; some of the bulge sources are close enough to the nucleus to be remnants of the tidal disruption of a giant by the massive central black hole. By using Chandra data in combination with ROSAT and XMM observations, we find most VSSs to be highly variable, fading from or brightening toward detectability on time scales of months. There is evidence for VSSs with low luminosities ($\sim 10^{36}$ erg s$^{-1}$).
description: 14 pages, 4 figures. Accepted for publication in ApJ. Classification of supersoft and quasisoft sources is clarified
The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in A Zebrafish Xenograft Colon Cancer Model
Creators: name: Basti, Alireza
name: Fior, Rita
name: Yalҫin, Müge
name: Póvoa, Vanda
name: Astaburuaga, Rosario
name: Li, Yin
name: Naderi, Julian
name: Godinho Ferreira, Miguel
name: Relógio, Angela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: circadian clock
subject: colon cancer
subject: zebrafish xenograft
subject: micrometastasis
subject: apoptosis
subject: proliferation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Malfunctions of circadian clock trigger abnormal cellular processes and influence tumorigenesis. Using an in vitro and in vivo xenograft model, we show that circadian clock disruption via the downregulation of the core-clock genes BMAL1, PER2, and NR1D1 impacts the circadian phenotype of MYC, WEE1, and TP53, and affects proliferation, apoptosis, and cell migration. In particular, both our in vitro and in vivo results suggest an impairment of cell motility and a reduction in micrometastasis formation upon knockdown of NR1D1, accompanied by altered expression levels of SNAI1 and CD44. Interestingly we show that differential proliferation and reduced tumour growth in vivo may be due to the additional influence of the host-clock and/or to the 3D tumour architecture. Our results raise new questions concerning host-tumour interaction and show that core-clock genes are involved in key cancer properties, including the regulation of cell migration and invasion by NR1D1 in zebrafish xenografts.
Ni abundance in the core of the Perseus Cluster: an answer to the significance of resonant scattering
Creators: name: Gastaldello, Fabio
name: Molendi, Silvano
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Using an XMM-Newton observation of the Perseus cluster we show that the excess in the flux of the 7-8 keV line complex previously detected by ASCA and BeppoSAX is due to an overabundance of Nickel rather than to an anomalously high Fe He$β$/Fe He$α$ ratio. This observational fact leads to the main result that resonant scattering, which was assumed to be responsible for the supposed anomalous Fe He$β$/Fe He$α$ ratio, is no longer required. The absence of resonant scattering points towards the presence of significant gas motions (either turbulent or laminar) in the core of the Perseus cluster.
description: 29 pages, 10 bw figures, accepted for publication in the Astrophysical Journal
Robust freeze-drying process re-design of a legacy product based on risk analysis and design of experiments
Creators: name: Clua-Palau, Gloria
name: Jo, Enric
name: Nikolic, Sasha
name: Coello, Jordi
name: Maspoch, Santiago
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In this study, a QbD freeze-drying process re-design applied to a lyophilized injectable drug product is presented. The main objective was to assess the freeze-drying process robustness using risk analysis and a proper experimental design. First, the product’s thermal fingerprint was characterized by thermal analysis and freeze-drying microscopy. Then, according to the output of the risk analysis, primary drying temperature and pressure were studied by a Doehlert DoE design with four responses; primary drying time, appearance, residual moisture content, and reconstitution time. Statistically significant MLR models were obtained for residual moisture content and primary drying time. In the latter, the temperature factor was the predominant factor to predict the duration of the primary drying stage. Two additional lab-scale batches were run to confirm the mathematical model predictions. Finally, optimal primary drying conditions (30 °C, 0.400 mbar) were selected to minimize the duration of the primary drying stage, while preserving the quality of the product. It was possible to set high temperature and pressure values because no collapse temperature was found during the thermal characterization of the product. Secondary drying temperature and time were defined based on the residual moisture content results. It was shown that secondary drying is robust between 30 °C and 50 °C and from 3 to 16 h. In conclusion, we were able to define a robust freeze-drying process which was further validated at an industrial scale with satisfactory results and approved by the health authorities in different countries around Europe.
Classify and Generate: Using Classification Latent Space Representations for Image Generations
Creators: name: Gopalakrishnan, Saisubramaniam
name: Singh, Pranshu Ranjan
name: Yazici, Yasin
name: Foo, Chuan-Sheng
name: Chandrasekhar, Vijay
name: Ambikapathi, ArulMurugan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Utilization of classification latent space information for downstream reconstruction and generation is an intriguing and a relatively unexplored area. In general, discriminative representations are rich in class-specific features but are too sparse for reconstruction, whereas, in autoencoders the representations are dense but have limited indistinguishable class-specific features, making them less suitable for classification. In this work, we propose a discriminative modeling framework that employs manipulated supervised latent representations to reconstruct and generate new samples belonging to a given class. Unlike generative modeling approaches such as GANs and VAEs that aim to model the data manifold distribution, Representation based Generations (ReGene) directly represent the given data manifold in the classification space. Such supervised representations, under certain constraints, allow for reconstructions and controlled generations using an appropriate decoder without enforcing any prior distribution. Theoretically, given a class, we show that these representations when smartly manipulated using convex combinations retain the same class label. Furthermore, they also lead to the novel generation of visually realistic images. Extensive experiments on datasets of varying resolutions demonstrate that ReGene has higher classification accuracy than existing conditional generative models while being competitive in terms of FID.
Parabolic Verma Modules and Invariant Differential Operators
Creators: name: Dobrev, V. K.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In the present paper we continue the project of systematic classification and construction of invariant differential operators for non-compact semisimple Lie groups. This time we make the stress on one of the main building blocks, namely the Verma modules and the corresponding parabolic subalgebras. In particular, we start the study of the relation between the parabolic subalgebras of real semisimple Lie algebras and of their complexification. Two cases are given in more detail: the conformal algebra of 4D Minkowski space-time and the minimal parabolics of classical real semisimple Lie algebras.
description: 8 pages, Plenary talk at Bogolyubov Conference, Moscow-Dubna, 9-13.9.2019