cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Examining and Addressing Men's Boating Safety Behaviours in Inuvik, Northwest Territories
Creators: name: Glass, Catherine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Injury prevention
gender
boating
drowning
Northwest Territories
Community-based participatory research

description: Injuries are one of the leading causes of death for individuals in Canada. Most injuries are predictable and preventable events that may be reduced by health promotion and injury prevention strategies. In particular, boating fatalities are a leading cause of injury death for men, particularly Aboriginal men, in northern Canada. Despite decades of water safety campaigns, Aboriginal men remain overrepresented in boating fatality statistics. Elevated rates of boating fatalities for Aboriginal men in northern Canada indicate that current water safety messages and initiatives may not be reaching those most vulnerable to boating incidents. My thesis, which is written in the publishable paper format and is comprised of two papers, investigates Aboriginal men’s boating incidents in Inuvik, Northwest Territories, Canada. In paper one, I use a community-based participatory research methodology informed by postcolonial feminist theory to investigate the risk factors that Aboriginal male residents identified as contributing to boating incidents in Inuvik, Northwest Territories. Together, we found that sex and gender, age, place, and lack of boating safety education are the most prominent risk factors for boating incidents. In paper two, I argue that community members are key holders of local knowledge and their expertise should thus be drawn upon by academic researchers and health programmers for the co-creation of injury prevention programs. In it, I provide an overview of the process that led to the co-creation of a boating education poster campaign in Inuvik. Together, the two papers in this thesis demonstrate that community-based strategies should be employed to address health inequities in boating incidents faced by Aboriginal men in the Northwest Territories.
A comparison of droplet and contact contamination using 3 simulated barrier techniques for COVID-19 intubation : a quality assurance study
Creators: name: Rose, Peter
name: Veall, John
name: Chima, Navraj
name: Vowels, Elena
name: Chitnis, Shruti
name: Flexman, Alana
name: Tang, Raymond
Publisher: name: Canadian Medical Association (Canada)
Year: 2021

description: Background: The intubation of patients with coronavirus disease 2019 (COVID-19) puts health care workers at risk of infection through aerosol, droplet and contact contamination. We evaluated the risk of droplet and contact contamination for health care workers using 3 intubation barrier techniques as part of a quality assurance study at our institution. Methods: This randomized quality assurance study was completed at a tertiary academic hospital in Vancouver, British Columbia, Canada, on Apr. 4, 2020. Participants in personal protective equipment performed simulated intubations on a manikin with (a) no barrier, (b) a clear plastic sheet covering the manikin and (c) a plexiglass intubation box over the manikin, in random order. Fluorescein was ejected from inside the manikin’s mouth to simulate droplet and contact spread during a standard intubation sequence. Two blinded independent assessors evaluated the location and degree of contamination on the intubator and assistant using an ultraviolet light. Contamination severity was rated in a standard fashion (0 = none; 1 = minor; 2 = major). The primary outcome was total contamination score and secondary outcomes were scores between intubator and assistant, anatomic areas contaminated and qualitative feedback on ease of intubation. Results: Five participants completed this study. Total contamination score was different between the 3 groups for the intubator (p = 0.02) but not the assistant (p = 0.2). For the intubator, the total contamination score was higher when the sheet was used (median 29 [interquartile range (IQR) 25–34]) than when the box was used (median 17 [IQR 15–22]) or when no barrier was used (median 18 [IQR 13–21]). All 5 participants reported challenges during intubation using the sheet. Interpretation: Use of a plastic sheet while intubating patients with COVID-19 may increase the risk of droplet and contact contamination during intubation and impede intubation. Further study should be undertaken before implementing barrier techniques in practice.
UZBEK TRADITION AND OF CEREMONIES PEOPLE IN PEDAGOGY CAUGHT PLACE
Creators: name: Sattorov, Abbas
Publisher: name: Zenodo
Year: 2025

description: Uzbek people his/her own many century-old history rich and colorful throughout culture created this of culture main layer and tradition and ceremonies organization The people 's traditions are from ancestors for generations pass upcoming , vital experience based on formed values , morals standards and aesthetic of views practical is the appearance . Customs people pedagogy basis they are young generation to educate , to society adaptation and national identity in formation important tool task The people will do it . pedagogy is of the people daily life , customs , rituals , oral tradition creativity , values through the youth upbringing is a system .
Analysis and Modulation of PACT, DICER and MBNL1 in the Context of Myotonic Dystrophy Type I
Creators: name: Azimi, Mehrdad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Myotonic Dystrophy Type I
DM1
PACT
DICER
TRBP
miRNA
PKR
Alternative splicing
Nuclear foci
MBNL1
DMPK
SERCA1
Insulin receptor
RISC

description: Myotonic Dystrophy Type I (DM1) is a multi-systemic genetic neuromuscular degenerative disease, has a prevalence in most populations of about 1:8000 and is caused by the nuclear retention of pathogenically expanded DMPK mRNA. A previous DM1 RNAi-kinome screen in our lab has identified kinases that reduced both count and area of DMPK mRNA foci in vitro. One such discovered kinase is PACT, which has showed to decrease foci count and area in DM1 fibroblasts by 30-50%. This study explored PACT as well as binding partner DICER involved in cellular RNA processing machinery, to highlight potential therapeutic targets in DM1. DM1 fibroblasts treated with PACT siRNA showed a non-significant trend of upregulation in MBNL1 mRNA and protein expression. PACT knockdown also showed trend of missplicing normalization in SERCA-1, more prominently seen in DM1-2000 human fibroblasts, whereas IR (insulin receptor) splicing remained unaffected. On the other hand, DICER knockdown did not have profound affect on foci integrity as well as MBNL1 RNA and protein xpressions in DM1 fibroblasts. SERCA-1 splicing in DICER siRNA treated samples also remained unchanged. We report here our findings in pursuit of potential therapeutic targets for the treatment of DM1.
Role of RNA Genome Structure and Paraspeckle Proteins In Hepatitis Delta Virus Replication
Creators: name: Beeharry, Yasnee
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Hepatitis Delta Virus
RNA promoter
paraspeckle
replication
covariation
RNA structure
DBHS proteins

description: The Hepatitis Delta Virus (HDV) is an RNA pathogen that uses the host DNA-dependent RNA polymerase II (RNAP II) to replicate. Previous studies identified the right terminal domain of genomic polarity (R199G) of HDV RNA as an RNAP II promoter, but the features required for HDV RNA to be used as an RNA promoter were unknown. In order to identify the structural features of an HDV RNA promoter, I analyzed 473,139 sequences representing 2,351 new R199G variants generated by high-throughput sequencing of a viral population replicating in 293 cells. To complement this analysis, I also analyzed the same region from HDV sequences isolated from various hosts. Base pair covariation analysis indicates a strong selection for the rod-like conformation. Several selected RNA motifs were identified, including a GC-rich stem, a CUC/GAG motif and a uridine at the initiation site of transcription. In addition, a polarization of purine/pyrimidine content was identified, which might represent a motif favourable for the binding of the host Polypyrimidine tract-binding protein-associated-splicing-factor (PSF), p54 and Paraspeckle Protein 1 (PSP1). Previously, it was shown that R199G binds both RNAP II and PSF, that PSF increased the HDV levels during in vitro transcription and that p54 binds R199G. In the present study, I showed that PSP1 also associates with HDV RNA and I investigated whether these proteins are required for HDV replication. My results show that knockdown of PSF, p54 and PSP1 resulted in a decrease of HDV accumulation. These proteins are highly concentrated in paraspeckles, which are nuclear structures involved in storage of transcripts generated by RNAP II. I found that upon viral replication in 293 cells, PSP1 appeared as bigger foci present outside of the nucleus, while PSF and p54 foci remained in the nucleus. NEAT1 is a long non-coding RNA essential for the formation of paraspeckles. Upon HDV replication, I found an increase of the intensity and size of NEAT1 foci that correlates with an increase of NEAT1 transcripts. Altogether, these data suggest that HDV replication results in an alteration of the paraspeckles structures, providing foundation for further investigation of the paraspeckles role in HDV cycle. Overall, the present study addresses the importance of the HDV RNA structure and of the host paraspeckle proteins for HDV replication.
РОЛЬ МИНЕРАЛЬНОГО СОСТАВА ВОДЫ В ФОРМИРОВАНИИ МОЧЕКАМЕННОЙ БОЛЕЗНИ У НАСЕЛЕНИЯ ФЕРГАНЫ
Creators: name: Отакулов, Гайратжон
Publisher: name: Zenodo
Year: 2025

description: Мочекаменная болезнь (МКБ) является распространённой патологией, особенно в регионах с жарким климатом и высоким содержанием минеральных веществ в питьевой воде. Мочекаменная болезнь занимает лидирующие позиции среди заболеваний мочевыводящей системы во всем мире. Факторы окружающей среды, в том числе состав питьевой воды, существенно влияют на риск её развития. В регионах с жёсткой водой, богатой кальцием и магнием, частота формирования уролитов значительно выше. Ферганская долина, характеризующаяся жарким климатом и особенностями минерального состава воды, представляет собой пример региона с высоким риском возникновения МКБ. Изучение этой связи имеет большое значение для разработки эффективных профилактических программ.
Optimizing Police Resources Deployment
Creators: name: Hashemian, Mozhdeh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Resources Deployment
Optimization

description: The Ottawa Police Service (OPS) deploys its resources based on the needs of predefined zones. However, the current zoning approach has been acknowledged as inefficient due to negative impacts on costs, proficiency, quality of services and time management. The zoning approach has also been acknowledged as inefficient due to its static nature, its inflexibility and its inability to adjust systematically according to the number of currently available police vehicles. It also cannot assist in addressing demand changes throughout the day in order to reduce call responses in neighbouring zones. Therefore, the demand variation could lead to a significant decrease in police efficiency, since those officers who have been allocated to other zones are not able to participate in events outside their zones without permission. It may cause a high volume of waiting calls and increased response time depending on the time of day, shifts, seasons, etc. Hence, the OPS needs to find a new model for resource deployment that can provide the same coverage but with better service quality. Resource allocation has always been a challenge for emergency services like police, fire emergency, and ambulance services since it has a direct impact on the efficiency and effectiveness of the service activities. The ambulance and fire emergency services have received research attention while the optimization of police resources remains largely ignored. While there are many similarities between ambulance and police deployment there are also significant differences that mean the direct transfer of ambulance models to police deployment is not feasible. This research addresses the lack of an effective tool for the deployment of police resources. We develop a simulation model that analyzes potential deployment plans in order to determine their effect on response times. The model has been developed in partnership with the Ottawa Police Service (OPS) and will address the obstacles, disadvantages, and geographical constraints of the existing allocation model. The OPS needs to align deployment with the service demand and their operational goals (response times, visibility, workload, compliance, etc.). Repositioning police vehicles in real time, helps in responding to future calls more effectively without adding more officers.
Emergence of Mass, Motion, and Gravity from  Quantum–Classical Field Tension
Creators: name: Parry, Dean Alan
Publisher: name: Zenodo
Year: 2025
Subjects: Gravity, Emergent Gravity, Quantum-Classical Transition, Field Tension, Dark Matter, Dark Energy, Time's Arrow, Mass Emergence, Spacetime Structure, Galaxy Rotation Curves

description: We propose a new theoretical framework in which mass, motion, and gravity are emergent phenomena arising from the dynamic tension between a fundamentally superluminal, time-reversible quantum field realm and localized, causal classical spacetime. In this model, mass is not fundamental but results from the trapping of quantum field tension under classical localization, while gravitational curvature arises from gradients in this trapped and residual tension.

This approach naturally resolves several outstanding anomalies in modern physics, including the absence of a graviton, the failure to quantize gravity, the nature of dark matter and dark energy, and the origin of inertia and time's arrow. We show that galaxy rotation curves can be explained without invoking exotic dark matter, and that General Relativity is recovered in the limit where quantum field gradients vanish. This unified framework connects microphysical (proton-scale) and cosmological (galaxy-scale) structure formation through a single underlying mechanism.

The theory refines the foundation of gravitation and spacetime, presenting gravity as an emergent manifestation of quantum-classical field tension rather than a fundamental interaction.
An Indigenous Methodology for Coming to Know Milo Pimatisiwin as Land-Based Initiatives for Indigenous Youth
Creators: name: Gaudet, Janice Cindy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Indigenous Research Methodology
Indigenous Youth Wellbeing
Omushkego

description: This research endeavour with Moose Cree First Nation provides insights into how emerging Indigenous methodologies are fundamentally grounded in an Indigenous epistemology that, for the purpose of this project, was found to be integral to youth and community wellbeing. More specifically, this project highlights an Indigenous perspective of health and wellbeing, milo pimatisiwin, that yields individual, collective and relational strengths with its focus on reconnecting youth to the land. This thesis offers methodological contributions in an effort to discuss research with Indigenous peoples beyond the participatory paradigm; it also develops on coming to know through the “visiting way” and elaborates further on Indigenous methods such as learning by doing concepts and conversational method. Discussing approaches of coloniality and settler-colonialism highlighted territoriality and land dispute issues, but most importantly here, these approaches established how the land is at the very core of the Omushkego people’s epistemology. Two land-based initiatives with Moose Cree First Nation were examined in this study. The initiatives provide insights into Indigenous resurgence as they relate to the land, to spirit, and to life stage teachings. The community experiences suggest how vital it is to center Indigenous knowledge in research and land-based initiatives for youth wellbeing as they contribute to developing, integrating and applying Indigenous methodologies, given this process is inter-related to fostering milo pimatisiwin. The Omushkegowuk people’s conceptions of health and wellbeing challenges colonial ideas and actions, and just as important, it allows for the production of knowledge within the context of Indigenous methods, experiences and wisdom.
Personalized Ventilation to Multiple Patients Using a Single Ventilator : Description and Proof of Concept
Creators: name: Han, Jay S.
name: Mashari, Azad
name: Singh, Devin
name: Dianti, Jose
name: Goligher, Ewan
name: Long, Michael
name: Ng, William
name: Wasowicz, Marcin
name: Preiss, David
name: Vesely, Alex
name: Kacmarek, Robert
name: Keshavjee, Shaf
name: Brochard, Laurent
name: Fisher, Joseph A.
name: Slutsky, Arthur S.
Publisher: name: Lippincott, Williams & Wilkins
Year: 2021

description: Objectives: To design and test a ventilator circuit that can be used for ventilation of two or more patients with a single ventilator, while allowing individualization of tidal volume, fractional concentration of oxygen, and positive end-expiratory pressure to each patient, irrespective of the other patient’s respiratory system mechanics. Design: Description and proof of concept studies. Settings: Respiratory therapy laboratory. Subjects: Ventilation of mechanical test lungs. Interventions: Following a previously advocated design, we used components readily available in our hospital to assemble two “bag-ina- box” breathing circuits. Each patient circuit consisted of a flexible bag in a rigid container connected via one-way valve to a test lung, along with an inline positive end-expiratory pressure valve, connected to the ventilator’s expiratory limb. Compressed gas fills the bags during “patient” exhalation. During inspiration, gas from the ventilator, in pressure control mode, enters the containers and displaces gas from the bags to the test lungs. We varied tidal volume, “respiratory system” compliance, and positive end-expiratory pressure in one lung and observed the effect on the tidal volume of the other. Measurements and Main Results: We were able to obtain different tidal volume, dynamic driving pressure, and positive end-expiratory pressure in the two lungs under widely different compliances in both lungs. Complete obstruction, or disconnection at the circuit connection to one test lung, had minimal effect (< 5% on average) on the ventilation to the co-ventilated lung. Conclusions: A secondary circuit “bag-in-the-box” system enables individualized ventilation of two lungs overcoming many of the concerns of ventilating more than one patient with a single ventilator.
title: Среда и распространенность ЗН репродуктивных органов у женского населения арктических территорий Якутии
Creators: name: Афанасьева, Л. Н.
name: Иванов, П. М.
name: Гоголев, Н. М.
name: Макарова, Н. Н.
name: Мыреева, С. А.
name: Николаева, Т. И.
name: Кириллина, М. П.
Publisher: name: Реноме
Year: 2018

description: Рост числа женщин, заболевших ЗН репродуктивных органов, связан со снижением рождаемости детей, непродолжительным периодом грудного вскармливания и наличием вредных для здоровья привычек. В росте показателей онкологической заболеваемости населения арктических территорий нельзя сбрасывать роль изменений, наблюдающихся в образе жизни, питании, особенно недостаточную обеспеченность растениеводческими продуктами, приводящую к дефициту жизненно важных питательных веществ. Кроме того, водная среда территорий бассейнов нижнего течения р. Колымы, Яны, Индигирки, Лены, Анабара подвергается загрязнению трансграничными загрязнителями, поступающими со стороны территорий районов с имеющимися горнодобывающими предприятиями, находящихся выше по течению рек.
Frequency noise mitigation in advanced interferometric fibre strain sensors
Creators: name: Lam, Timothy T-Y
Publisher: name: The Australian National University
Year: 2011
Subjects: subject: QC411.L36 2011
subject: Lasers Noise
subject: Interferometry
subject: Optical fiber detectors
subject: Fiber optics

description: Frequency noise greatly limits the resolution of high resolution fibre optic strain sensors. The experiments presented in this thesis provide an effective way of obtaining better strain resolution in systems limited by laser frequency noise. In this thesis two main methods are utilised; active frequency noise suppression through feedback control, and post processing noise removal. In chapters 2, 3, and 4, we explore different methods to reduce the frequency noise in lasers used to interrogate fibre interferometric strain sensing systems. We investigate the use of local fibre lasers and their applicability to high resolution strain sensing. We use radio frequency read out techniques to provide a high resolution read out of strain and frequency fluctuations. Then using active feedback, we lock the laser to a stable Mach-Zehnder interferometer. We demonstrate, with active feedback, ultra-high strain resolutions of 14 f{u220A}/{u221A}Hz at infrasonic frequencies. To allow for more flexibility and ease of use, we used a field programmable gate arrays for digital locking and signal processing systems. We present an analysis of the potential performance of a digital feedback system using the Pound-Drever-Hall technique. In this analysis, we discuss the noise sources and their affect on a digital feedback loop. We then experimentally characterise and verify the theoretical analysis. With this digital system we then explore the use of an absolute frequency reference. An interrogation system was designed and implemented that extends the range of an absolute sensing systems. Using this method, we are able to improve a free running system by up to 1.5 orders of magnitude whilst improving the range by a factor of 10 over standard pre-stabilised systems. We then propose and implement a frequency noise insensitive sensing system based on post processing techniques. We utilise time-delay interferometry, a technique developed for gravitational wave detection to eliminate frequency noise through post processing. The technique is combined with digitally-enhanced interferometry, and slightly modified to account for, and remove, several noise sources, including lead fibre phase noise, that is common to fibre optic strain sensors. The design and performance considerations are discussed and analysed, and a first time proof of concept experiment is reported. The design implemented has shown to significantly improve the performance of a frequency noise limited strain sensor.
The Impact of Environmental Heavy Metal Exposures on Pregnancy and Birth Outcomes
Creators: name: Au, Felicia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: maternal biomarkers
metals
pregnancy
birth outcome
matrix metalloproteinase

description: Background: There is still a paucity of information on maternal biological mechanisms specific to adverse birth outcomes despite maternal environmental exposure and health status being known to influence neonatal morbidity and mortality. The purpose of this study was to explore maternal biomarkers pertinent to infant development in utero, specifically matrix metalloproteinases (MMPs), and determine their relationships to environmental heavy metals such as arsenic, cadmium, lead, mercury, and manganese as well as their relationships to outcomes such as preterm birth, low birth weight and small for gestational age infant outcomes. Methods: A secondary data analysis on 1533 mother-infant pairs from the Maternal and Infant Research on Environmental Chemicals (MIREC) cohort was conducted to statistically test relationships between metals and biomarkers, as well as biomarkers and outcome. A systematic literature review and meta-analysis was also conducted to identify the interdependencies between maternal blood biomarkers relating to adverse pregnancy outcomes. Results: Multivariate regression models were used to estimate odds ratios (OR) for the association between metal concentrations in quartiles and both high (90%) and low (10%) maternal MMP levels. Significant metal-related effects were observed with different MMP responses. A total of 54 studies (35 for meta-analysis), including 43,702 women and evaluating 50 biomarkers, met the inclusion criteria and all subgroups of biomarkers showed significant associations with birth outcomes with no apparent publication bias. Conclusions: Maternal plasma markers may serve as potentially valuable tools in the investigation of maternal molecular mechanisms, especially select toxicity pathways underlying metal-mediated adverse infant outcomes. Further research is still needed to evaluate biomarkers such as proteomic and genetic profiles in other various maternal biological samples.
Le sentiment d’appartenance à la communauté militaire : une étude sur l’auto-évaluation de la santé et de la perception du taux de criminalité dans le quartier
Creators: name: Ouellet, Eric
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Capital social
Communauté militaire
Sentiment d'appartenance
Auto-évaluation de la santé
Criminalité
Statistiques
Canada

description: Cette thèse porte sur le sentiment d’appartenance à la communauté comme indicateur de capital social afin de mesurer son impact sur l’auto-évaluation de la santé et de la perception du taux de criminalité dans le quartier. Notre regard se porte sur la communauté militaire, car nous croyons que ce groupe présente des caractéristiques sociales homogènes qui ont été institutionnalisées. À la suite d’analyses statistiques de données secondaires provenant des Forces armées canadiennes (DGRAPM, 2010), nous suggérons qu’il y a une différence fondamentale entre le concept du Sentiment d’appartenance à la communauté et le concept du Sentiment d’appartenance au quartier : le premier influence une auto-évaluation de la santé positive et le second atténue la perception du taux de criminalité dans le quartier. Donc, bien que les concepts soient associés au capital social, ils n’interviennent pas de la même manière sur la qualité de vie des militaires.
title: Научное наследие И. Иерига в «Портфелях Г. Ф. Миллера»
Creators: name: Дюльденко, А. А.
Publisher: name: Реноме
Year: 2018

description: Обнаруженная в «Портфелях Г. Ф. Миллера» РГАДА уникальная рукопись Иоганна Иерига, датированная 1778 г., проливает свет на процесс создания известного труда академика П. С. Палласа «Собрание исторических сведений о монгольских народах», а также помогает дополнить сведения о роли Г. Ф. Миллера в становлении отечественного востоковедения.

Ключевые слова: портфели Миллера, Иоганн Иериг, Герхард Фридрих Миллер, Петр Симон Паллас.
La justice et l’équité à observer dans la division des personnes juridiques publiques, en particulier des diocèses et des paroisses (c. 122)
Creators: name: Bationo, Emmanuel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Division juridique
Diocèses
Canonique
Paroisses
Personne juridique
Personne public
Justice
Équité
Église
Catholique
Biens divisibles
Biens indivisibles
Fondation
Donation
Personne juridique publique
Division patrimoine

description: Les personnes juridiques publiques, dans l’Église catholique, peuvent acquérir des biens (c. 1255). Elles en ont le droit de propriété (c. 1256). En cas de division, les biens doivent être partagés de façon juste et équitable entre les parties (c.122). Comment procéder concrètement au partage juste et équitable du patrimoine? Puisqu’il n’y a pas encore de document public officiel qui nous l’indique, nous voulons faire ici une contribution à la réflexion pour une proposition de procédure, à partir du sujet suivant : « La justice et l’équité à observer dans la division des personnes juridiques publiques, en particulier des diocèses et des paroisses (c. 122) ». Le premier chapitre porte sur les personnes juridiques dans l’Église. Ensembles de personnes ou de choses et sujets de droits et d’obligations, les caractéristiques et les normes essentielles régissant le statut des personnes juridiques sont présentées. Les diocèses et les paroisses ainsi que les normes de leurs réorganisations y sont exposés. Le deuxième chapitre porte sur l’étude des antécédents du canon 122, nous permettant de le situer dans son origine et son évolution. À l’aide de l’analyse et de l’interprétation du texte, nous en relevons certains aspects à prendre en compte dans un partage juste et équitable entre les parties. Le troisième chapitre est une application concrète du canon 122 aux diocèses et aux paroisses. Des réflexions et des propositions sont faites pour leur division, prenant en compte : le territoire, la population, le personnel, les biens communs, les dettes, les fondations et les donations, les gains ou les charges pouvant apparaître après la division. Le quatrième chapitre nous donne une procédure à suivre pour la division des diocèses et des paroisses, qui tienne compte à la fois de l’avant et de l’après décret de division.
Tracking Low Temperature Tectonism of the St. Lawrence Platform and Humber Zone, Southern Quebec Appalachians through Apatite and Zircon (U-Th)/He Thermochronology
Creators: name: Emberley, Justin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Thermochronology
Apatite
Zircon
St. Lawrence Platform
Appalachians
Humber Zone

description: The St. Lawrence Platform (SLP) and Humber Zone (HZ) of the southern Quebec Appalachians has historically been explored as a potential hydrocarbon reservoir. Extensive vitrinite reflectance studies on the basin resolved the degree of thermal maturation yet the timing of the thermal maximum is not well undertood. Determining the timing of such low temperature events can allow for a better understanding of the shallow crustal processes that may have allowed for the generation and entrapment of oil and gas. We have employed apatite (AHe) and zircon (ZHe) (U-Th)/He thermochronmetry across a network of late Cambrian to late Ordovician siliciclastic and Grenvillian basement samples in order to resolve the history within the ~210-35°C window. Single crustal dates from individual samples show age dispersion by as much as 300 m.y. with a strong positive to negative correlation with increasing eU concentration. A similar positive correlation can be observed when significant intra-sample grain size variation is present. AHe and ZHe data in the southwestern portion of the basin, near Montreal, allow for thermal maxima of up to 200°C to occur either during the late Ordovician, as a result of the Taconic orogeny, or from the continued sedimentation into the Devonian as a result of the Acadian orogeny. Regional burial trends deduced from these thermal maxima along with local paleo-geothermal gradients indicate that if sedimentation continued after the late Ordovician there was no significant increase in burial in southwestern portion of the SLP as previously suggested. Maximum heating is followed by a protracted cooling through the ZHe partial retention zone (PRZ) into the late Jurassic and early Cretaceous where the cooling rate increases by an order of magnitude through the AHe PRZ until ca. 100 Ma. The timing of this accelerated cooling is coeval with the passage of the Great Meteor Hot Spot across the area; the cooling may be a result of increased erosion from thermal uplift. Within the HZ, both the external and internal sections experienced rapid cooling through the Silurian after the Taconic thermal maximum. The timing of relatively rapid cooling coincides with documented normal faulting and back-thrusting in the orogen, which is the likely cause of exhumation. The HZ witnessed protracted cooling through the late Jurassic, when there is a one order of magnitude increase in cooling rate until surface conditions are attained. Increased recognition of these low temperature events has augmented our understanding of the evolution of accretionary orogens and consequently reduces the risks associated with oil and gas exploration.
Intracellular pH Regulation in H+-ATPase-rich Ionocytes in zebrafish larvae Using in vivo Ratiometric Imaging
Creators: name: Hong Meng, Yew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: zebrafish
danio rerio
ion regulation
imaging
ratiometric
in vivo
time lapse
ionocyte
HR cell

description: The H+-ATPase rich (HR) cells of zebrafish larvae are a sub-type of ion-transporting cell located on the yolk sac epithelium that are responsible for Na+ uptake and H+ extrusion. Current models of HR cell ion transport mechanisms in zebrafish larvae are well established, but little is known about the involvement of the various ion transport pathways in regulating intracellular acid-base status. In the present study, a ratiometric imaging technique using the pH indicator dye BCECF was developed to monitor intracellular pH (pHi) continuously in larval zebrafish HR cells in vivo. Initial validation experiments demonstrated that HR cells subjected to respiratory acidosis (1% CO2) or metabolic alkalosis (20 mM NH4Cl) exhibited changes in BCECF 513/438 emission ratios which were consistent with the expected effects of these treatments on pHi. Subsequent experiments focussed on the involvement of the two principal apical membrane acid excretory pathways, the Na+/H+ exchanger (isoform NHE3b; zslc9a3.2) and the H+-ATPase (atpv1aa) in pHi regulation. Additionally, the role of HR cell carbonic anhydrase (“CA2-like a”) was investigated because of its presumed role in providing H+ for Na+/H+ exchange and H+-ATPase. To do so, relative HR cell pHi changes were monitored during acid-base challenges in shams and in fish experiencing morpholino gene knockdown of either NHE3b, H+-ATPase or “CA2-like a”. The temporal pattern and extent of intracellular acidification during exposure of fish to 1% CO2 and the extent of post-CO2 alkalization were altered markedly in fish experiencing knockdown of “CA2-like a”, NHE3b or H+-ATPase. Although there were slight differences among the three knockdown experiments, the typical response was a greater degree of intracellular acidification during CO2 exposure and a reduced capacity to restore pHi to baseline levels post-hypercapnia. Knockdown of “CA2-like a”, although presumed to limit H+ availability to NHE3b and H+-ATPase, yielded qualitatively similar results to knockdown of either single H+ excretory pathway. The metabolic alkalosis and subsequent acidification associated with NH4Cl exposure and its washout were largely unaffected by gene knockdown. Overall, the results suggest markedly different mechanisms of intracellular acid-base regulation in zebrafish HR cells depending on the nature of the acid-base disturbance.
Practice-led research, the ethnographer and unearthing knowledge: crossing the thresholds
Creators: name: Hecq, Dominique
Publisher: name: Swinburne
Year: 2024

description: This article is within the context of a prose writer immersed in creative practice. It takes into account the 'nebulous' concept of practice-led research arising from its 'newness' and 'subtleties', addressed in this paper. It considers how former practice in consistent methodology as a scientist amplifies the intricacy of experiential research. It outlines how I have problematised practice-led research: its qualitative and non-quantifiable nature; the elusiveness of defining new knowledge in diverse creative research settings; and the dual roles of artist and scholar, in a type of collaboration that engenders knowledge while creating art. Finding knowledge in practice-led research is also retrospective because outcomes are yet uncertain. This paper offers practicable solutions in the bridges of immersive practice and mentoring, both valuable instruments to reorient the solitary researcher. The bridges can help uncover framing strategies and shape intellectual and artistic engagement to unravel creative art as answerable to knowledge.
Supporting Pathology Process Management with Real-time Business Intelligence
Creators: name: Li, Wei Chen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: dashboard
Business Intelligence
pathology process management
pathology informatics

description: [Context] Clinical pathology is a medical specialty that uses laboratory analysis of tissues and fluids to diagnose diseases. As emerging methodologies and technologies extend their realm to anatomical pathology, pathology facilities are faced with new challenges related to the increasing volume and complexity of patient cases in their work processes. [Problem] Existing tools that monitor process data show limitations in supporting pathology process management. They lack the capability of identifying emerging process bottlenecks in a real-time manner, and this prevents facility managers from conducting corrective actions proactively. [Methodology] Applying the Design Science Research Methodology, this thesis proposes and builds a Business Intelligence solution that provides visual analysis and real-time monitoring functions to support pathology process management. A usability study with expert participants from the Eastern Ontario Regional Laboratory Association was conducted to validate this solution. [Results] The proposed solution meets the requirements of the experts and can provide efficient, flexible, and multi-tenancy support to users in the context of their daily professional activities.
title: Назначение препарата афатиниб в III линии терапии аденокарциномы легкого с мутацией EGFR
Creators: name: Маркарова, Е. В.
name: Когония, Л. М.
name: Сташук, Г. А.
name: Королева, О. А.
Publisher: name: Реноме
Year: 2018

description: Назначение афатиниба пожилым пациентам, даже при условии проведенных в анамнезе линий ХТ, является эффективным лечением аденокарциномы легких при наличии EGFR мутации.
Quantum Criticality in One-dimensional Fermi Gases
Creators: name: Yi, Seongjoon
Publisher: name: The Australian National University
Year: 2013

description: In this thesis, we present a recent study of the one-dimensional attractively interacting two-component Fermi gas with an external magnetic field. We analytically study the quantum phase diagram, equation of state, quantum criticality, and universal scalings of the model, using the thermodynamic Bethe ansatz equations. We present a high precision equation of state from which universal scaling functions are derived; we show that the thermodynamic properties display universal scaling behaviour at quantum criticality. Expression of high-order-accuracy entropy and specific heat are also analytically derived. Moreover, we present an independent confirmation of the equation of state through an efficient numerical approach of treating the thermodynamic Bethe ansatz equations for which the contributions from the spin strings with length larger than a value of $n_c$ are calculated analytically.
Distribution, Source and Cycling of Organic Carbon and Nitrogen in the Icy Soils of University Valley (McMurdo Dry Valleys of Antarctica)
Creators: name: Faucher, Benoit
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Permafrost
Habitability

description: Between 2009 and 2013, 16 ice-bearing permafrost cores were collected from 10 polygons along the floor of University Valley (McMurdo Dry Valleys of Antarctica) and were subsequently analysed in order to assess the geochemical properties of the valley’s icy soils and ground ice. Elemental analysis showed that icy soils located in the seasonally non-cryotic zone (NCZ) of the valley contained (on average) twice as much organic carbon (1.19 mg/g) as the ice cemented permafrost soils sampled in its perennially cryotic zone (PCZ). It also showed that nitrogen accumulation in the icy soils was a result of atmospheric fallout and chemical weathering of mineral soils. Isotopic analysis showed that the organic matter contained in the valley’s icy soils are mostly derived from the deposition and burial of cryptoendolithic communities living in the adjacent sandstone valley walls. Dissolved organic carbon (DOC) concentration measures indicated that soils containing the highest amounts of DOC were enriched in 13CDOC relatively to soils with low DOC concentrations. This indicated that microbial activity in soils was the highest during past super interglacial periods. A soil habitability index calculation from Stoker et al. (2010) was used to establish that soils located in the NCZ were more habitable than soils sampled in the PCZ and also presumably more habitable than soils at many Mars landing sites.
L'Espace professionnel de l'infirmière au sein d'une équipe multidisciplinaire : Clinique externe de psychiatrie de l'Hôpital Montfort, 1976-2002
Creators: name: Moya, Silvia Maria Valentina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Infirmière
Équipe multidisciplinaire
Psychiatrie
Espace professionnel
Clinique externe

description: À la suite de la désinstitutionnalisation psychiatrique, les services communautaires sont devenus essentiels et ont permis l’introduction des équipes multidisciplinaires comme nouvelle approche de soins en santé mentale. À Ottawa, c’est en juillet 1973 que l’Hôpital Montfort ouvre les portes de sa clinique externe psychiatrique où l’équipe multidisciplinaire – composée d’un psychiatre, un travailleur social, un psychologue, un ergothérapeute, un récréologue et une infirmière – prend en charge le suivi des patients francophones de l’est-ontarien. Cette thèse de maîtrise en sciences infirmières propose une étude de cas qui analyse en profondeur le parcours de vie psychiatrique d’une patiente francophone suivie à la clinique externe de Montfort pendant 26 ans afin de rendre compte de l’espace professionnel occupé par les infirmières psychiatriques au sein de l’équipe multidisciplinaire. Ce faisant, notre but est de déconstruire le mythe qui sous-entend que l’infirmière est peu présente dans les équipes multidisciplinaires et que son rôle dans ces dernières est peu significatif. Les objectifs de cette thèse sont: • Documenter l’espace relationnel que développe l’infirmière avec la patiente témoin; • Cibler les interactions que développent les principaux membres de l’équipe multidisciplinaire, et leurs fréquences, avec la patiente témoin; • Analyser l’impact des professionnels de l’équipe multidisciplinaire sur le parcours psychiatrique de la patiente témoin. L’accès aux dossiers psychiatriques des patients hospitalisés sur le Département de psychiatrie de Montfort se révèle être une porte d’entrée privilégiée pour comprendre les soins psychiatriques depuis les années 1970 jusqu’à nos jours. Les dossiers sont la mémoire écrite de l’histoire de soins de chaque patient ayant fréquenté le programme de santé mentale de Montfort.
title: «История Академии наук» Г. Ф. Миллера как источник данных о начальном этапе русской филологии
Creators: name: Власов, С. В.
name: Волков, С. С.
name: Московкин, Л. В.
Publisher: name: Реноме
Year: 2018

description: В статье рассматриваются данные о начальном этапе русской филологии (1725–1733), содержащиеся в «Истории Академии наук» Г. Ф. Миллера. Несмотря на субъективное, иногда отрицательное, отношение Миллера к академическим русистам, он описал наиболее ярких из них, приведя в ряде случаев сведения о них, не встречающиеся в других источниках. В «Истории Академии наук» описаны основные труды, характеризующие деятельность академических русистов в 1725–1733 гг.

Ключевые слова: XVIII в., Императорская академия наук, Г. Ф. Миллер, «История Академии наук», русская филология.
Experiencing Resonance: Choral Singing in Medical Education
Creators: name: Nemoy, Laura
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: medical education
communities of practice
choral singing
medical humanities
community music
humanistic healthcare

description: Arts and humanities programming is becoming increasingly incorporated in the medical school, balancing the biomedical paradigm, and nurturing human and emotional qualities and understandings in medical students. Music is often listed among these arts and humanities disciplines; yet there exists an acknowledged gap in the literature pertaining to musical activities and programming in the medical school, despite the prevalence of choirs, a cappella groups, small instrumental ensembles, and musical theatre programs in medical schools. Literature on choirs, musical ensemble, and community music suggests that choral singing can cultivate many of the intra and interpersonal skills that medical humanities programming encourages, such as empathy, cooperation, self-awareness, and human connection. Within the medical humanities, music has been tied to metaphors of “medicine as a performing art” or “the art of listening,” but very little literature exists delving into the actual musical experience of medical students. Drawing from medical humanities, community music, and education theory, and shaped by the metaphor of musical and emotional ‘resonance,’ this phenomenological study explores the relationships between choral singing and medical scholarship. Through semi-structured interviews, the primary goal of this inquiry was to develop in-depth understandings of the experiences of medical students singing as members of a musical community of practice: an extra-curricular medical school choir at a Canadian university. Findings indicate that choir is an informal, non-medical venue where students can engage with their musical identity during medical school; that choral singing can offer a means of stress-relief and creative outlet, mitigating symptoms of student burnout; and that engagement in the choir builds meaningful relationships and a supportive, connected community. Moreover, this study describes the role of music and choral singing in medical humanities and medical education, as well as suggests how involvement in a medical school choir may influence a medical student’s professional identity formation.
A Continuous Analog of Run Length Distributions Reflecting Accumulated Fractionation Events
Creators: name: Yu, Zhe
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: genomics
whole genome duplication
analysis of runs
probability modeling
duplicate gene deletion

description: We propose a new, continuous model of the fractionation process (duplicate gene deletion after polyploidization) on the real line. The aim is to infer how much DNA is deleted at a time, based on segment lengths for alternating deleted (invisible) and undeleted (visible) regions. After deriving a number of analytical results for "one-sided" fractionation, we undertake a series of simulations that help us identify the distribution of segment lengths as a gamma with shape and rate parameters evolving over time. This leads to an inference procedure based on observed length distributions for visible and invisible segments. We suggest extensions of this mathematical and simulation work to biologically realistic discrete models, including two-sided fractionation.