cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterization and Treatment of Unilateral Facial Muscle Spasm in Linear Scleroderma: A Case Report
Creators: name: Danisi, Fabio
name: Guidi, Emma
Publisher: name: Columbia University
Year: 2018
Subjects: Scleroderma (Disease)
Spasms
Dystonia
Botulinum toxin
Neurology

description: Background: Linear scleroderma has been associated with muscle spasms ipsilateral to skin lesions.  Typically, spasms are generated by trigeminal innervated muscles, leading to hemi-masticatory spasm (HMS).

Case Report: We report a case of linear scleroderma associated with spasm of muscles innervated not only by the trigeminal, but also by the facial nerve.

Discussion: We review the patient’s successful treatment with incobotulinumtoxinA, a formulation of botulinum toxin that has not been reported for use in this condition.
Fractional Dehn twists in knot theory and contact topology
Creators: name: Kazez, William H.
name: Roberts, Rachel
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M50 (Primary) 53D10 (Secondary)

description: Fractional Dehn twists give a measure of the difference between the relative isotopy class of a homeomorphism of a bordered surface and the Thurston representative of its free isotopy class. We show how to estimate and compute these invariants. We discuss the the relationship of our work to stabilization problems in classical knot theory, general open book decompositions, and contact topology. We include an elementary characterization of overtwistedness for contact structures described by open book decompositions.
description: We have removed an incorrect assumption about properties of meridional disks of Heegaard decompositions of S^3 and have added a conjecture about stabilizations of knots in S^3
Chemokine-mediated modulation of autoimmunity in type 1 diabetes
Creators: name: Bischoff, Loraine Helena
Publisher: name: University of British Columbia
Year: 2012

description: Type 1 diabetes is an autoimmune disorder characterized by destruction of insulin-producing beta cells by autoreactive T cells. Despite management of type 1 diabetes with insulin therapy, affected individuals face devastating complications, such as blindness and kidney failure. Islet transplantation has emerged as a promising therapy to replace beta cells; unfortunately, it is still challenged by a high rate of graft failure due to allo- and recurrent auto-immune responses. The pathogenesis of type 1 diabetes results from a combination of genetic and environmental factors that cause an imbalance in regulatory mechanisms, including defects in T regulatory (Treg) and natural killer T (NKT) cells. We believe that enhancing the activity of these cells locally may have the desirable effect of modulating the immune response against beta cells. Interestingly, the chemokines CCL22 and CCL17 preferentially recruit Tregs. We hypothesized that expression of these chemokines in islets would prevent beta cell destruction by enhancing influx of immunoregulatory cells. We used viral vectors to induce expression of CCL22 or CCL17 in islets and tested this hypothesis in models of spontaneous and recurrent autoimmune diabetes in the non-obese diabetic mouse. We found that CCL22 expression in pancreatic islets prevented diabetes development and protected islet transplants from recurrent autoimmunity, although not indefinitely. CCL22-expressing islets recruited Tregs, invariant NKT and plasmacytoid dendritic cells, resulting in a tolerogenic milieu characterized by lower IFNγ levels and increased expression of indoleamine 2,3-dioxygenase. CCL22 induced expression of CTLA-4, ICOS and CD62L on Tregs and enhanced their ability to modulate dendritic cell function, indicatory of a superior suppressive function. Notably, depletion of Tregs abrogated CCL22’s protective effect, suggesting that CCL22 modulatory properties are dependent on Tregs. When comparing CCL22 and CCL17, we found similar recruitment of Tregs and invariant NKT cells, but unlike CCL22, CCL17 did not impact Treg function. Nevertheless, CCL17 expression in islet grafts was equally protective from recurrent autoimmunity. Our findings suggest a novel strategy for protecting beta cells from immune attack, by using chemokines CCL22 or CCL17 to harness the natural regulatory properties of immune cells such as Tregs and invariant NKT cells.
Familial Cortical Myoclonic Tremor and Epilepsy, an Enigmatic Disorder: From Phenotypes to Pathophysiology and Genetics. A Systematic Review
Creators: name: Van Den Ende, Tom
name: Sharifi, Sarvi
name: Van Der Salm, Sandra M. A.
name: Rootselaar, Anne-Fleur Van
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Myoclonus
subject: Tremor
subject: Epilepsy
subject: Genetics
subject: FOS: Biological sciences
subject: Medicine

description: Background: Autosomal dominant familial cortical myoclonic tremor and epilepsy (FCMTE) is characterized by distal tremulous myoclonus, generalized seizures, and signs of cortical reflex myoclonus. FCMTE has been described in over 100 pedigrees worldwide, under several different names and acronyms. Pathological changes have been located in the cerebellum. This systematic review discusses the clinical spectrum, treatment, pathophysiology, and genetic findings.

Methods: We carried out a PubMed search, using a combination of the following search terms: cortical tremor, myoclonus, epilepsy, benign course, adult onset, familial, and autosomal dominant; this resulted in a total of 77 studies (761 patients; 126 pedigrees) fulfilling the inclusion and exclusion criteria.

Results: Phenotypic differences across pedigrees exist, possibly related to underlying genetic differences. A “benign” phenotype has been described in several Japanese families and pedigrees linked to 8q (FCMTE1). French patients (5p linkage; FCMTE3) exhibit more severe progression, and in Japanese/Chinese pedigrees (with unknown linkage) anticipation has been suggested. Preferred treatment is with valproate (mind teratogenicity), levetiracetam, and/or clonazepam. Several genes have been identified, which differ in potential pathogenicity.

Discussion: Based on the core features (above), the syndrome can be considered a distinct clinical entity. Clinical features may also include proximal myoclonus and mild progression with aging. Valproate or levetiracetam, with or without clonazepam, reduces symptoms. FCMTE is a heterogeneous disorder, and likely to include a variety of different conditions with mutations of different genes. Distinct phenotypic traits might reflect different genetic mutations. Genes involved in Purkinje cell outgrowth or those encoding for ion channels or neurotransmitters seem good candidate genes.
Length scales, collective modes, and type-1.5 regimes in three-band superconductors
Creators: name: Carlstrom, Johan
name: Garaud, Julien
name: Babaev, Egor
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The recent discovery of iron pnictide superconductors has resulted in a rapidly growing interest in multiband models with more than two bands. In this work we specifically focus on the properties of three-band Ginzburg-Landau models which do not have direct counterparts in more studied two-band models. First we derive normal modes and characteristic length scales in the conventional U(1) three-band Ginzburg-Landau model as well as in its time reversal symmetry broken counterpart with $U(1)\times Z_2$ symmetry. We show that in the latter case, the normal modes are mixed phase/density collective excitations. A possibility of the appearance of a massless phase-difference mode associated with fluctuations of the phase difference is also discussed. Next we show that gradients of densities and phase differences can be inextricably intertwined in vortex excitations in three-band models. This can lead to very long-range attractive intervortex interactions and appearance of type-1.5 regimes even when the intercomponent Josephson coupling is large. In some cases it also results in the formation of a domain-like structures in the form of a ring of suppressed density around a vortex across which one of the phases shifts by $π$. We also show that field-induced vortices can lead to a change of broken symmetry from U(1) to $U(1)\times Z_2$ in the system. In the type-1.5 regime, it results in a semi-Meissner state where the system has a macroscopic phase separation in domains with broken U(1) and $U(1)\times Z_2$ symmetries.
description: Version 3: Corrected som inconstancies in the parameter set in Fig.2 Also som minor typos corrected. No changes to results or conclusions
The local symmetries of M-theory and their formulation in generalised geometry
Creators: name: Berman, David S.
name: Godazgar, Hadi
name: Godazgar, Mahdi
name: Perry, Malcolm J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the doubled field theory approach to string theory, the T-duality group is promoted to a manifest symmetry at the expense of replacing ordinary Riemannian geometry with generalised geometry on a doubled space. The local symmetries are then given by a generalised Lie derivative and its associated algebra. This paper constructs an analogous structure for M-theory. A crucial by-product of this is the derivation of the physical section condition for M-theory formulated in an extended space.
description: 20 pages, v2: Author Name corrected, v3: typos corrected
Majorana Fermions and Exotic Surface Andreev Bound States in Topological Superconductors: Application to CuxBi2Se3
Creators: name: Hsieh, Timothy H.
name: Fu, Liang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The recently discovered superconductor CuxBi2Se3 is a candidate for three-dimensional time- reversal-invariant topological superconductors, which are predicted to have robust surface Andreev bound states hosting massless Majorana fermions. In this work, we analytically and numerically find the linearly dispersing Majorana fermions at k = 0, which smoothly evolve into a new branch of gapless surface Andreev bound states near the Fermi momentum. The latter is a new type of Andreev bound states resulting from both the nontrivial band structure and the odd-parity pairing symmetry. The tunneling spectra of these surface Andreev bound states agree well with a recent point-contact spectroscopy experiment[1] and yield additional predictions for low temperature tunneling and photoemission experiments.
description: PRL in press, 4 pages, 3 figures + Supplementary Material; supercedes 1109.3464 and includes additional results
DEVELOPING A PROTOTYPE WELFARE ASSESSMENT PROTOCOL FOR HORSES AND DONKEYS
Creators: name: DALLA COSTA, EMANUELA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Animal welfare describes a potentially measurable quality of a living animal and it relates to both the animal?s feelings as well as to its health state. Public concern about equine welfare has steadily grown during recent years not only among riders and horsepersons, but also among passionates and general public.
In the present thesis, with the global aim to develop a welfare assessment protocol for horses and donkeys that can be used on-farm, a review of the literature to date and research studies carried out in the frame of the Animal Welfare Indicators project (AWIN) are presented. The importance of the use of valid and reliable animal-based indicators is highlighted throughout the thesis as well as on-farm feasibility. Horse Grimace Scale is presented as a new indicator to assess pain in horses. Other studies are related to the validation and refinement of other animal-based indicators such as a Novel Object fear test, Human-Animal relationship tests and the Qualitative Behaviour Assessment. Furthermore, the outstanding innovation of the AWIN project is the dissemination of the scientific results to stakeholders through the preparation of new training tools, such as learning objects and apps. In fact, the possibility of using new tools to disseminate little pieces of knowledge can help to increase awareness of people working with equines in their welfare, shorten the time needed for dissemination of good scientific information and indirectly to improve the welfare condition of horses and donkeys.
The welfare indicators and the training material developed in the frame of the AWIN project and reported in this thesis represent a useful toolbox that can be used to respond to the increasing of the expectations toward a more efficient and transparent evaluation of animal welfare for species where no EU standards exist.
A new functionalized reduced graphene oxide adsorbent for removing heavy metal ions in water via coordination and ion exchange
Creators: name: Zhang, Chao-Zhi
name: Chen, Bin
name: Bai, Yuan
name: Xie, Jing
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Astronomical and Space Sciences not elsewhere classified

description: Heavy metal ion pollution has become a serious problem. In this paper, a new type of adsorbent, reduced graphene oxide grafted by 4-sulfophenylazo groups (RGOS), was synthesized to adsorb heavy metal ions in an aqueous solution via two kinds of adsorption modes, ion exchange and coordination. The maximum adsorption capacities of the RGOS for Pb(II), Cu(II), Ni(II), Cd(II) and Cr(III) were 689, 59, 66, 267 and 191 mg/g, respectively. Adsorption equilibrium time of RGOS for heavy metal ions is no more than 10 min. Adsorption mechanism was supposed based on elemental analyses, adsorption data, and Fourier transform infrared spectra.
Line Transfer through Clumpy, Large-Scale Outflows: Lyman Alpha Absorption and Halos around Starforming Galaxies
Creators: name: Dijkstra, Mark
name: Kramer, Roban Hultman
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present constrained radiative transfer calculations of Lyman Alpha (Lya) photons propagating through clumpy, dusty, large scale outflows, and explore whether we can quantitatively explain the Lya halos that have been observed around Lyman Break Galaxies. We construct phenomenological models of large-scale outflows which consist of cold clumps that are in pressure equilibrium with a constant-velocity hot wind. First we consider models in which the cold clumps are distributed symmetrically around the galaxy, and in which the clumps undergo a continuous acceleration in its 'circumgalactic' medium (CGM). We constrain the properties of the cold clumps (radius, velocity, HI column density, & number density) by matching the observed Lya absorption strength of the CGM in the spectra of background galaxies. We then insert a Lya source in the center of this clumpy outflow, which consists of 1e5-1e6 clumps, and compute observable properties of the scattered Lya photons. In these models, the scattered radiation forms halos that are significantly more concentrated than is observed. In order to simultaneously reproduce the observed Lya absorption line strengths and the Lya halos, we require - preferably bipolar - outflows in which the clumps decelerate after their initial acceleration. This deceleration is predicted naturally in 'momentum-driven' wind models of clumpy outflows. In models that simultaneously fit the absorption and emission line data, the predicted linear polarization is ~30-40% at a surface brightness contour of S=1e-18 erg/s/cm^2/arcsec^2. Our work illustrates clearly that Lya emission line halos around starforming galaxies provide valuable constraints on the cold gas distribution & kinematics in their circumgalactic medium, and that these constraints complement those obtained from absorption line studies alone.
description: 18 pages, 9 figures, plus 6 pages Appendix. Accepted to MNRAS after a minor revision (fixed some typos, clarified some of the text, added a few references.)
Istradefylline for Restless Legs Syndrome Associated with Parkinson’s Disease
Creators: name: Nuermaimaiti, Maierdanjiang
name: Oyama, Genko
name: Kasemsuk, Chayut
name: Hattori, Nobutaka
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Restless legs syndrome
subject: Parkinson's disease
subject: Adenosine--Receptors
subject: Neurosciences
subject: FOS: Clinical medicine

description: Restless legs syndrome (RLS) is the most common movement disorder and is characterized by the feeling of an urgent need to move the legs while lying down or resting. RLS worsens during the evening and at night and is relieved by leg movement.1,2 It is also known that RLS is commonly comorbid with Parkinson’s disease (PD).3 Although the exact pathological mechanism of RLS is unknown, dopaminergic medications for PD, such as levodopa and other dopamine agonists, symptomatically improve RLS as well.4 Istradefylline is a highly selective adenosine A2A receptor antagonist that is thought to modulate the overactivated striatopallidal pathway (indirect pathway) in PD,4 reducing the duration of the ‘‘off’’ state and extending the ‘‘on’’ state without inducing dyskinesia.5 Istradefylline has been recently approved in Japan for the treatment of PD, but, to date, there are no data on the effect of istradefylline on RLS in PD. Here we report the cases of three patients with RLS comorbid with PD who were treated with istradefylline.
Measure of multipartite entanglement with computable lower bounds
Creators: name: Hong, Yan
name: Gao, Ting
name: Yan, Fengli
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we present a measure of multipartite entanglement ($k$-nonseparable), $k$-ME concurrence $C_{k-\mathrm{ME}}(ρ)$ that unambiguously detects all $k$-nonseparable states in arbitrary dimensions, where the special case, 2-ME concurrence $C_{2-\mathrm{ME}}(ρ)$, is a measure of genuine multipartite entanglement. The new measure $k$-ME concurrence satisfies important characteristics of an entanglement measure including entanglement monotone, vanishing on $k$-separable states, convexity, subadditivity and strictly greater than zero for all $k$-nonseparable states. Two powerful lower bounds on this measure are given. These lower bounds are experimentally implementable without quantum state tomography and are easily computable as no optimization or eigenvalue evaluation is needed. We illustrate detailed examples in which the given bounds perform better than other known detection criteria.
description: 12 pages, 3 figures
Myoclonic Jerks, Exposure to Many Cats, and Neurotoxoplasmosis in an Immunocompetent Male
Creators: name: Reyes, Antonio Jose
name: Ramcharan, Kanterpersad
name: Giddings, Stanley Lawrence
name: Aboh, Samuel
name: Rampersad, Fidel
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Myoclonus
subject: Movement disorders
subject: Toxoplasmosis
subject: Epilepsy
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Myoclonic jerks are due to sudden, brief, involuntary muscle contractions, positive myoclonus, or brief cessation of ongoing muscular activity, negative myoclonus, and may be difficult to recognize.

Case Report: We describe an immunocompetent, adult, male patient with sleep-related, multifocal, myoclonic jerks and neurotoxoplasmosis with abnormal cerebrospinal fluid but normal brain imaging. There was complete resolution of the myoclonus with antitoxoplasmosis therapy after 1 week, and no relapse after 1 year.

Discussion: Neurotoxoplasmosis may be subtle in presentation, difficult to diagnose, and more common than realized, and it is being increasingly implicated in epileptogenesis in humans.
Achieving synergy between international trade and human rights : a proposal for mainstreaming human rights in the WTO
Creators: name: Godwin- A Hart, Sotonye
Publisher: name: University of British Columbia
Year: 2012

description: The integration of trade and human rights is a ubiquitous topic that has dominated academic and policy research in recent years. While it is settled that the fields of trade and human rights are distinct, the relationship between the two have become more prominent especially with the conclusion of the Uruguay Trade Round which introduced trade subjects that diminish policy space of governments. The interactions of trade and human rights have been shown in modern times to affect the realization of some human rights in developing countries and LDCs. This influence of trade liberalization on the realization of human rights has necessitated studies that explore options for integration of trade and human rights in the WTO so that trade obligations do not stymie the fulfilment of human rights obligations. Bearing in mind the lex specialis nature of the WTO and human rights systems, an integration of trade and human rights in the WTO system must be predicated on a concept or norm common to both systems. This concept or norm is development. While development is intrinsic to both the WTO and the human rights systems, there is an urgent need for a shift in perspective in the WTO idea of development from a purely economic process to a human right that inures on individuals and peoples. This shift in perspective will mandate the introduction and enforcement of certain characteristics of the right to development: free, active and inclusive participation of all, both developed and developing countries in the trade process of the WTO, not only in terms of numbers but in terms of meaningful participation and must guarantee benefits for all Members. The human right to development approach will also entail a strengthening of existing special and differential treatment provisions. It is the argument of this thesis that a shift to a human right to development approach in the WTO space will contribute to the possibility of integrating trade and human rights. The ongoing Doha Trade Round provides the very forum for such shift. The problem however is whether the WTO Members have the political will to do this.
How does population density affect agricultural intensification and household well-being in Africa? Insights from 5 countries
Creators: name: Benfica, Rui
name: Chamberlin, Jordan
name: Headey, Derek
name: Jayne, Thom
name: Josephson, Anna
name: Mather, David
name: Milu Muyanga
name: Ricker-Gilbert, Jacob
Publisher: name: Gates Open Research
Year: 2019

description: How does population density affect agricultural intensification and household well-being in Africa? Insights from 5 countries
Supersymmetry of a different kind
Creators: name: Alvarez, Pedro D.
name: Valenzuela, Mauricio
name: Zanelli, Jorge
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Superconductivity (cond-mat.supr-con)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A local supersymmetric action for a (2+1)-dimensional system including gravity, the electromagnetic field and a Dirac spin-1/2 field is presented. The action is a Chern-Simons form for a connection of the OSp(2|2) group. All the fields enter as parts of the connection, that transforms in the adjoint representation of the gauge group. The system is off-shell invariant under local (gauge) supersymmetry. Although the supersymmetry is locally realized, there is no spin-3/2 gravitino, and is therefore not supergravity. The fields do not necessarily form supersymmetric doublets of equal mass, and moreover, the fermion may acquire mass through the coupling with the background geometry, while the bosons --the U(1) field and the spin connection-- remain massless.
description: 10pages, 6 sections, new comments, two references added, a few typos corrected. Final form to be published in JHEP
LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY
Creators: name: SENSI, CRISTINA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: A series of large population studies have revealed the existence of a strong inverse correlation between plasma levels of high-density lipoprotein cholesterol (HDL-C) and cardiovascular risk. Accordingly, HDL has become a major target for the development of novel therapies for the treatment of atherosclerotic cardiovascular disease.
LCAT catalyzes cholesteryl ester synthesis and plays a central role in HDL structure and metabolism. Also, LCAT promotes the reverse cholesterol transport, and mediates its atheroprotective effects. Recent studies demonstrated that decreasing LCAT activity possibly has positive effects on HDL structure/function, and may represent a novel therapeutic strategy to reduce cardiovascular risk. To exploit LCAT therapeutic prospects, the availability of new potent and selective LCAT modulators is mandatory. With the present work, we identified molecules able to inhibit LCAT enzymatic activity implementing an in silico strategy.
The computational approach can be deployed in two different ways: i) the availability of large chemical databases, and the computational power of the new computers allow a very efficient in silico high-throughput screening starting from the target structure and independently of any pharmacophoric hypothesis; ii) the knowledge of the active site and of the catalytic mechanism of a target can be exploited for ab initio computer-aided drug design.
We have designed, through a de novo approach, an irreversible inhibitor, which is the first specific LCAT inhibitor known, and can be considered as a lead compound for the identification of new active molecules belonging to the same chemical family.
In parallel, the high-throughput screening carried out on LCAT identified some very potent reversible inhibitors, which can be of interest in further drug development steps.
Globally, this project produced innovative pharmacological entities to be further developed for a completely new therapeutic approach to the treatment of atherosclerotic cardiovascular diseases.
STUDIO IN VIVO DI SCAFFOLD PER LA RIGENERAZIONE OSSEA E CARTILAGINEA.
Creators: name: CAMPAGNOL, MARINO
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: The treatment of large osseous defects remains a challenging clinical problem in orthopedic surgery and, due to the lack of comparative studies, it is not always possible to define the best treatment choice for the different osseous and cartilage pathologies. As the field of tissue engineering develops, researchers face a large number of degrees of freedom regarding the choice of material, architecture, seeding, and culturing. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopedic implants prior to clinical use in humans.
 We have investigated the differences in bone density between various species as factors for consideration when choosing an animal model. We also investigated in vivo a possible correlation between osteointegration and the increase in electrical impedance module. Due to the similarity of skeletal parameters and bone-healing rates the swine seem to be a good model in bone and joint surgery. We have examined in two tests, scaffolds for osteochondral tissue repair both in minipigs and in commercial pigs, to verify the differences between the two models and which one is the best.
Final report--agricultural public expenditure review at the federal and subnational levels in Nigeria (2008-12)
Creators: name: Aderibigbe Olomola
name: Tewodaj Mogues
name: Tolulope Olofinbiyi
Publisher: name: Gates Open Research
Year: 2019

description: Final report--agricultural public expenditure review at the federal and subnational levels in Nigeria (2008-12)
HACAT AS A MODEL FOR KERATINOCYTESTRANSFORMATION
Creators: name: MARTYNOVA, ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Mutations of the tumor suppressor gene p53 occur in more than 50% of
human malignancies and lead to the loss of suppressor activity. Moreover
frequently p53 mutants gain novel, oncogenic properties by transcriptional
activation of the genes, involved in cellular proliferation, cell survival and
angiogenesis. Today?s challenge is to understand mechanisms underlying the
gain-of-function of mutant p53 proteins.
By the example of KLF4 promoter we demonstrate that mutant p53 can
carries out its gain-of-function by interaction with another p53 family member,
transcription factor p63. In the first report we provide strong evidence that KLF4
is negatively controlled by p63 in normal skin in the presence of physiological
levels of wild type p53 (wtp53) and that this regulation is subverted by
oncogenic mutations of p53, establishing a direct link between these TFs,
commonly overexpressed in squamous cell carcinoma (SCC).
These results inspired us to investigate the mechanisms of mutant p53
gain-of-function on the genome scale. In the second manuscript we demonstrate
that mutant p53 HaCaT alleles are pro-growth and mutp53 have thousands of
binding sites in the human genome; they affect gene expression profoundly,
both by binding with p63 to consensus elements and by being tethered by other
TFs to their locations.
Although 2 mutant p53 alleles are definitely gain-of-function in the
HaCaT, they are not sufficient to render these cells malignant. Based on the
sphere-forming assay we developed novel model for the tumorigenic conversion
of the HaCaT cells: while immortalized keratinocytes display transformed
phenotype in vitro and not tumorigenic upon injection into nude mice, HaCaTderived
spheres give rise to the SCC in vivo. Thus, this simple model can be
3
useful for the future studies of the genetic and phenotypic signatures during
SCC initiation and development.
There is an indication that mutant p53 can execute its gain-of-function
via interaction with NF-Y transcription factor. Ongoing study is devoted to the
investigation of NF-YA subunit role in the processes of cellular proliferation
and apoptosis in the cells with different p53 status.
Additional file 3 of Effects of qigong exercise on the physical and mental health of college students: a systematic review and Meta-analysis
Creators: name: Lin, Jianping
name: Gao, Yi fang
name: Guo, Yue
name: Li, Ming
name: Zhu, Yuxiang
name: You, Ruoshi
name: Chen, Shaoqing
name: Wang, Shizhong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Supplementary Material 3: PRISMA checklist
title: Einfluss unterschiedlicher Konservierungsmethoden auf die mechanische in vitro Stabilität von Knochen am Beispiel porciner Metatarsalia
title: Influence of different conservation methods on the mechanical in vitro stability of bones -A comparative study using porcine metatarsals
titleType: AlternativeTitle
Creators: name: Dos Santos, Vanessa
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: Porcine
Formalin
porcine
Alkohol-Glycerin
Konservierungsmethoden
Medical sciences Medicine
Medizin
Konservierung
Thiel
embalming
bone
thiel
osteosynthesis
biomechanics
formalin
conservation
Fixierungsmethoden
Fixierung
Biomechanik,
Knochen
Metatarsalia
Biomechanik
Frech-Frozen
fixation

description: Zur Etablierung neuer Osteosyntheseimplantate sind multiple Testverfahren an in vitro- Präparaten der gängige Standard. Dabei werden gegenwärtig frische, sowie frisch eingefrorene oder formalinfixierte Knochen verwendet und anschließend einer biomechanischen Testung ausgesetzt. Inwieweit eine solche Konservierung bzw. Fixierung die mechanischen Eigenschaften des Knochens unter den unterschiedlichen Belastungen beeinflusst, ist in der Literatur nur unzureichend untersucht. Ziel dieser Arbeit war es, den Einfluss unterschiedlicher Konservierungs- und Fixierungsmethoden auf die mechanische Stabilität unter standardisierten Bedingungen zu untersuchen. Frische porcine Metatarsalia wurden nach erfolgter Präparation entsprechend der Konservierungs- bzw. Fixierungsmethode in 7 Gruppen aufgeteilt: Frische Knochen, Eingefrieren (-18°C), Einfrieren mit zyklischem Auftauen, im Vakuum gekühlt aufbewahrte frische Knochen (4°C), sowie nach Formalin-, Thiel- oder Alkohol- Glycerinfixierung. Vor und nach Konservierung/Fixierung erfolgte die Bestimmung der Knochendichte mittels Dual-Röntgen-Absorptiometrie (DXA). Für die Frakturerzeugung und mechanische Testung des Knochens wurde ein 3-Punkt- Biegemodell verwendet. Um den Einfluss der Konservierungs/-Fixierungsmethoden auf eine Osteosynthese zu untersuchen, wurden die frakturierten Knochen anschließend mit einer Plattenosteosynthese (DCP Kleinfragment-System, Synthes® Umkirch Deutschland) versorgt und erneut getestet. Betrachtet man die Ergebnisse bei Frakturentstehung, so zeigte sich ein einheitlicheres Bruchmuster bei chemischer Fixierung, im Gegensatz zu frischen oder physikalisch konservierten Knochen. Bei der Bruchkraft und Maximallast zeigten sich keine signifikanten Unterschiede. Wird jedoch die Druckverformung bei der Bruchkraft betrachtet, so ist diese sowohl bei Formalin- als auch bei Alkohol-Glycerinfixierung signifikant niedriger als bei frisch präparierten Knochen. Ähnliches gilt für die 47 Verformung bei Maximallast. Auch nach Osteosynthese zeigen chemisch fixierte Knochen eine geringere Druckverformung im Vergleich zu frischen Knochen. Die Ergebnisse zeigen, dass die getesteten physikalischen Konservierungsverfahren keinen Einfluss auf die mechanische Stabilität von Knochen haben. Bei chemischer Fixierung hingegen gilt diese Aussage nur eingeschränkt, so dass auf diese Weise fixierte Knochen nur für ausgewählte Fragestellungen herangezogen werden sollten.
Block-modified Wishart matrices and free Poisson laws
Creators: name: Banica, Teodor
name: Nechita, Ion
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We study the random matrices of type $\tilde{W}=(id\otimesφ)W$, where $W$ is a complex Wishart matrix of parameters $(dn,dm)$, and $φ:M_n(\mathbb C)\to M_n(\mathbb C)$ is a self-adjoint linear map. We prove that, under suitable assumptions, we have the $d\to\infty$ eigenvalue distribution formula $δm\tilde{W}\simπ_{mnρ}\boxtimesν$, where $ρ$ is the law of $φ$, viewed as a square matrix, $π$ is the free Poisson law, $ν$ is the law of $D=φ(1)$, and $δ=tr(D)$.
description: 18 pages
Weather Risk: How does it change the yield benefits of nitrogen fertilizer and improved maize varieties in sub-Saharan Africa?
Creators: name: Hurley, Terrance
name: Jawoo Koo
name: Kindie Tesfaye
Publisher: name: Gates Open Research
Year: 2019

description: Weather Risk: How does it change the yield benefits of nitrogen fertilizer and improved maize varieties in sub-Saharan Africa?
title: Verlängerung der Verarbeitungszeit von Kompositen mit einer neuartigen weißen LED-Arbeitsfeldbeleuchtung
Creators: name: von Bülow, Albrecht
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: Verarbeitungszeit
camphorquinone
Zahnfüllung
Zahnmedizin
light curing
photoinitiator
Campherchinon
Komposit
LED
Aushärtung
dental filling
Medical sciences Medicine
Medizin
weiß
Lumineszenzdiode
Verbundwerkstoff

description: Die meisten lichthärtenden Komposite für Zahnfüllungen enthalten Campherchinon als Photoinitiator und können gezielt von einer Polymerisationslampe mit blauem Licht ausgehärtet werden. Diese Wellenlängen sind auch in dem Licht einer Standard- Behandlungsplatzlampe enthalten, sodass es bei der Modellation zu einer ungewollt frühen Aushärtung kommen kann. Das Material wird oberflächlich spröde und bei einer weiteren Modellation bilden sich Risse in der Oberfläche, sodass das Füllungsmaterial ausgetauscht werden muss. Um dies zu vermeiden, kann die Beleuchtungsstärke der Lichtquelle reduziert werden. Alternativ kann das kritische Spektrum unterhalb von 500 nm herausgefiltert werden oder eine gelbe LED mit einem Spektrum oberhalb von 500 nm verwendet werden. Beide Möglichkeiten, die Verarbeitungszeit zu verlängern, erzeugen eine ungewohnte Beleuchtungssituation und reduzieren die Wahrnehmbarkeit von Kontrasten für den Behandler. Ausgehend von dieser Problemstellung wird in der vorgelegten Arbeit eine Konversions-Leuchtdiode entwickelt, die weißes Licht emittiert und eine längere Verarbeitungszeit von campherchinonhaltigen Kompositen als herkömmliche LED-Kopflampen bietet. Zunächst wird die Anregungs-LED der Konversions- Leuchtdiode mit einem Emissionsmaximum bei 425 nm festgelegt. Sie emittiert Licht in einem Bereich, in dem das Verhältnis zwischen einer geringen Anregung des Photoinitiators Campherchinon und einer hohen Anregung des S-Zapfen im Auge besonders günstig ist. Aufbauend auf dieser LED wurde ein mit ihr zu kombinierender Fluoreszenzstoff ausgewählt, der Licht oberhalb von 500 nm emittiert. Die Bewertung der LEDs erfolgte durch die Verarbeitungszeit von campherchinonhaltigen Kompositen mit einem akustischen Messsystem bei einer Beleuchtungsstärke von 10.000 lx. Dabei werden die Farbtemperatur und die Spektren bei der Analyse der LEDs berücksichtigt. Aufbauend auf den Messergebnissen der Vorversuche wurde eine weiße LED entwickelt und von der OSA Opto Light GmbH als Prototyp produziert. Die Verarbeitungszeit lag mit dieser LED bei einer Beleuchtungsstärke von 10.000 lx für verschiedene Komposite zwischen 6:40 min bis 13:20 min. Im Vergleich zu einer herkömmlichen Kopflampe ist dies eine Verlängerung der Verarbeitungszeit um den Faktor 3 bis 5,5. Die Farbtemperatur beträgt 3.000 K und wird als weiß wahrgenommen. Mit dieser LED können in der klinischen Anwendung in einem ausreichend langen Zeitfenster lichthärtbare Komposite in Ruhe verarbeitet werden. Gleichzeitig wird die Verarbeitung durch die weiße Ausleuchtung des Arbeitsfeldes unterstützt.
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐ¾ÑÐ¼Ñ Ð¸ ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿ÐµÑÐ°ÑÐ½ÑÑ Ð´ÑÐ· Ð½Ð° ÐºÐ°ÑÐµÑÑÐ²Ð¾ SLM-Ð¿ÐµÑÐ°ÑÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Investigation of the influence of shape and location printed nozzles for SLM-printing quality
Creators: name: Ð¥Ð¾Ð»Ð¾ÑÑÐ¾Ð², ÐÐ»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐÐµÑÐ°ÑÐ½ÑÐµ Ð¼Ð°ÑÐ¸Ð½Ñ
3D-Ð¿ÐµÑÐ°ÑÑ
Ð¿ÐµÑÐ°ÑÐ½ÑÐµ Ð´ÑÐ·Ñ
Ð¿ÐµÑÐ°ÑÐ½ÑÐµ ÑÑÐ°Ð½ÑÐ¸Ð¸
ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ Ð´ÑÐ·
Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸
3D-rinting
printing nozzles
printing stations
nozzle arrangement
strength increase

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¼ÐµÑÐ¾Ð´Ð° Ð²Ð·Ð°Ð¸Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿ÐµÑÐ°ÑÐ½ÑÑ Ð´ÑÐ·. ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ: 1. Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð¾Ð² ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿ÐµÑÐ°ÑÐ½ÑÑ Ð´ÑÐ· ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ Ð¿ÐµÑÐ°ÑÐ½ÑÑ ÑÑÐ°Ð½ÑÐ¸Ð¹; 2. Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐµÐ¹ Ð²Ð·Ð°Ð¸Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ; 3. ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ¿Ð¾ÑÐ¾Ð±Ð° ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿ÐµÑÐ°ÑÐ½ÑÑ Ð´ÑÐ·; 4. ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð´Ð°ÑÐ¸Ð¹ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð¼ Ð¿ÑÐ¾Ð´ÐµÐ»Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÐ¹ ÑÐ¿Ð¾ÑÐ¾Ð± Ð²Ð·Ð°Ð¸Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿ÐµÑÐ°ÑÐ½ÑÑ Ð´ÑÐ· ÑÐ½Ð¸Ð²ÐµÑÑÐ°Ð»ÑÐ½ÑÐ¹ Ð´Ð»Ñ Ð±Ð¾Ð»ÑÑÐ¸Ð½ÑÑÐ²Ð° Ð·Ð°Ð´Ð°Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¸ ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ.
description: This work is devoted to the development of an optimal method of mutual arrangement of printing nozzles. The tasks that were solved in the course of the work: 1. study of existing methods of arrangement of printing nozzles of existing printing stations; 2. study of the peculiarities of mutual arrangement; 3. patent search; 4. development of the method of arrangement of printing nozzles; 5. development of technical recommendations for use. The result of the work done is the developed method of mutual arrangement of printing nozzles universal for the majority of tasks. Practical and technical recommendations for use are developed.
"New York Story" Revisited
Creators: name: Garafola, Lynn
Publisher: name: Columbia University
Year: 2018
Subjects: Dance
Choreography
Choreographers

description: Labels, wall texts, and reflections on the exhibition "New York Story: Jerome Robbins and His World," curated by Lynn Garafola, Donald and Mary Oenslager Gallery, The New York Public Library for the Performing Arts, March 25 - June 28, 2008.

The labels, wall exits, and reflections that follow are an effort to revisit an exhibition that did not, alas, have a published catalogue or a robust website.  Exhibitions are like performances.  When they close, they are dismantled, and the objects, their magic gone, sent back to their boxes.  In revisiting "New York Story:  Jerome Robbins and His World," I wanted to evoke the experience of walking through the Donald and Mary Oenslager Gallery of the New York Public Library for the Performing Arts, with the reader enjoying by suggestion and as an act of imagination the numerous objects on display tracing the remarkable career of Jerome Robbins as an artist of the ballet, Broadway, and concert stage in mid-twentieth-century New York.  This is the second of three exhibitions I have curated about ballet in New York City from the 1930s to the late twentieth century.  As such it complements "Dance for a City: Fifty Years of the New York City Ballet" (New-York Historical Society, 1999) and "Arthur Mitchell: Harlem’s Ballet Trailblazer" (Wallach Art Gallery, 2018).   I remain deeply grateful to the many colleagues and friends at the New York Public Library for the Performing arts who made this exhibition and the research that accompanied it a memorable experience.
Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor
Creators: name: Barbosa, Raquel
name: Mendonça, Marcelo
name: Ladeira, Filipa
name: Miguel, Rita
name: Bugalho, Paulo
Publisher: name: Columbia University
Year: 2017
Subjects: subject: Tremor
subject: Dysautonomia
subject: Sleep disorders
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Non-motor symptoms can be present in essential tremor (ET). We intend to assess the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and dysautonomic symptoms in ET patients and evaluate the differences between patients with ET and RBD (ET-RBD and ET without RBD [ET-nonRBD]).

Methods: All ET patients were contacted by telephone. Autonomic symptoms were assessed using the Scales for Outcomes in Parkinson’s Disease-Autonomic (SCOPA-AUT) questionnaire, and RBD symptoms with the RBD screening questionnaire (RBDSQ) using ≥5 as a cut-off for probable RBD (pRBD).

Results: From 92 ET patients contacted, 53 (55% female) were included. The mean age at assessment was 73.6±19 years, and the average disease duration was 19.9±17.3 years. Fourteen patients (26.4%) had pRBD and 52 (98.1%) reported at least one autonomic symptom, the most prevalent being urinary symptoms (96%). The ET-RBD group had higher SCOPA-total and thermoregulatory scores than ET-nonRBD patients (13.9±9.6 vs. 7.7±5.1, p = 0.017 and 2.5±2.0 vs. 0.9±1.6, p = 0.001). There were no other differences between groups.

Discussion: Our results suggest that pRBD is common in ET, and its presence is associated with dysautonomic symptoms. As these symptoms are known to be prodromal symptoms of Parkinson’s disease (PD), we question if this patient subgroup has a higher risk of developing a synucleinopathy.
Measurements of branching fraction ratios and CP-asymmetries in suppressed B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^- decays
Creators: name: CDF Collaboration
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We report the first reconstruction in hadron collisions of the suppressed decays B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^-, sensitive to the CKM phase gamma, using data from 7 fb^-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B^- -> D(-> K^+ pi^-)K^- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 \pm 8.6(stat)\pm 2.6(syst)]\times 10^-3, R^+(K) = [42.6\pm 13.7(stat)\pm 2.8(syst)]\times 10^-3, R^-(K)= [3.8\pm 10.3(stat)\pm 2.7(syst]\times 10^-3, as well as the direct CP-violating asymmetry A(K) = -0.82\pm 0.44(stat)\pm 0.09(syst) of this mode. Corresponding quantities for B^- -> D(-> K^+ pi^-)pi^- decay are also reported.
description: 8 pages, 1 figure, accepted by Phys.Rev.D Rapid Communications for Publication
Deciphering the influence of the cultivar on the phenolic content of virgin olive oil
Creators: name: S. Tomé-Rodríguez a b c ,  C.A. Ledesma-Escobar a b c ,  H. Miho e ,  C. Muñoz e ,  F. Priego-Capote a b c d
Publisher: name: Zenodo
Year: 2023

description: a

Department of Analytical Chemistry, University of Cordoba, Cordoba, Spain

b

Chemical Institute for Energy and Environment (IQUEMA), Campus of Rabanales, University of Cordoba, Cordoba 14014, Spain

c

Maimónides Institute for Biomedical Research (IMIBIC), Reina Sofía University Hospital, Cordoba, Spain

d

CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Carlos III Health Institute, Madrid, Spain

e

Department of Agronomy, Maria de Maeztu Unit of Excellence, Campus of Rabanales, University of Cordoba, Spain

Abstract

Virgin olive oil (VOO) phenols are valued for their health and organoleptic properties. The phenolic content of VOO is influenced by several factors, with particular emphasis on cultivar. However, the cultivar influence is a combination of several variables, including genotype, fatty acid (FA) profile, and fruit moisture; the last two variables condition the polarity of the extraction phases. Here, we evaluated the phenolic variability by extracting the effect of the fruit moisture and the FA profile from the cultivar factor. In a set of 40 cultivars monitored for three crop seasons, the cultivar effect was represented by differences in the conversion from oleuropein and ligstroside aglycones to oleacein and oleocanthal. Complementary, the fruit moisture positively favored the enrichment of VOOs in oleocanthal (285 mg/kg vs 380 mg/kg in the low and high moisture groups, respectively) while oleic acid showed a positive effect on the enrichment of VOOs in aglycone isomers of oleuropein (181 mg/kg vs 233 mg/kg in the low and high C18:1 content groups, respectively) and ligstroside (178 mg/kg vs 217 mg/kg in the low and high C18:1 content groups, respectively).
Kohn's theorem and Newton-Hooke symmetry for Hill's equations
Creators: name: Zhang, P. M.
name: Gibbons, G. W.
name: Horvathy, P. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Hill's equations, which first arose in the study of the Earth-Moon-Sun system, admit the two-parameter centrally extended Newton-Hooke symmetry without rotations. This symmetry allows for extending Kohn's theorem about the center-of-mass decomposition. Particular light is shed on the problem using Duval's "Bargmann" framework. The separation of the center-of-mass motion into that of a guiding center and relative motion is derived by a generalized chiral decomposition.
description: Published version. 22 pages 1 figure