cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Magnetoelectric coupling, Berry phase, and Landau level dispersion in a biased bilayer graphene
Creators: name: Zhang, L. M.
name: Fogler, M. M.
name: Arovas, D. P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the energy spectrum of a graphene bilayer in the presence of transverse electric and magnetic fields. We find that the resulting Landau levels exhibit a nonmonotonic dependence on the electric field, as well as numerous level crossings. This behavior is explained using quasiclassical quantization rules that properly take into account the pseudospin of the quasiparticles. The pseudospin generates the Berry phase, which leads to a shift in energy quantization and results in a pseudo-Zeeman effect. The latter depends on the electric field, alternates in sign among the two valleys, and also reduces the band gap. Analytic formulas for other pseudospin-related quantities, such as the anomalous Hall conductivity, are derived and compared with prior theoretical work.
description: 19 pages, 15 figures
EGb 761® Does Not Affect Blood Coagulation and Bleeding Time in Patients with Probable Alzheimer’s Dementia - Secondary Analysis of a Randomized, Double-Blind Placebo-Controlled Trial
Creators: name: Kloft, Charlotte
name: Hoerr, Robert
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Ginkgo
subject: EGb 761®
subject: blood coagulation
subject: bleeding time
subject: acetylsalicylic acid
subject: warfarin
subject: interaction
subject: safety
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Following reports of bleeding upon Ginkgo intake, we assessed whether Ginkgo extract EGb 761® affects coagulation or platelet function or increases the risk of bleeding. In a double-blind, placebo-controlled trial, prothrombin time, activated partial thromboplastin time, international normalized ratio and bleeding time were measured in patients with Alzheimer’s dementia at baseline, weeks 6 and 26. A total of 513 patients were randomized to 120 mg (n = 169) or 240 mg EGb 761® (n = 170) or placebo (n = 174). No relevant changes were found for coagulation parameters and bleeding time. Numbers of bleeding-related adverse events were similar in all groups. Concomitant intake of acetylsalicylic acid was documented for 68 patients in the placebo group and 105 in the EGb 761® groups. Within these groups, the means at baseline and week 26 differed by less than 1 unit for prothrombin time and bleeding time and less than 0.1 unit for international normalized ratio. Data on warfarin treatment in nine patients each taking placebo or EGb 761® did not indicate enhancement of warfarin effects by EGb 761®. No evidence was found that EGb 761® affects hemostasis or increases the bleeding risk. No pharmacodynamic interactions with warfarin or acetylsalicylic acid were found.
Geometry and paleo-ice content of rock glaciers in the southeastern Alps (NE Italy – NW Slovenia)
Creators: name: Boccali, C.
name: Žebre, M.
name: Colucci, R. R.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Rock glaciers in the southeastern Alps of Slovenia and Italy have been mapped in detail using high resolution digital elevation model and orthophotos, supported by field-based observations. A total of 52 rock glaciers with an area of 3.40 km2 have been delineated on a rock glacier map, divided in 18 sections at a scale of 1:15,000. Several geometrical parameters of rock glaciers have been calculated and their activity degree has been inferred. 90% of rock glaciers have been classified as relict, while the rest are assumed to be of uncertain activity and might still contain some ice. The volumetric ice content and water volume equivalent of the studied rock glaciers for the period of their activity has been calculated to 0.055 ± 0.011 km3 and 0.049 ± 0.010 km3, respectively, which is very close to the ice volume of glaciers reconstructed for this area during the little ice age to 0.069 km3.
The Relation Between Halo Shape, Velocity Dispersion and Formation Time
Creators: name: Ragone-Figueroa, C.
name: Plionis, M.
name: Merchan, M.
name: Gottlober, S.
name: Yepes, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use dark matter haloes identified in the MareNostrum Universe and galaxy groups identified in the Sloan Data Release 7 galaxy catalogue, to study the relation between halo shape and halo dynamics, parametrizing out the mass of the systems. A strong shape-dynamics, independent of mass, correlation is present in the simulation data, which we find it to be due to different halo formation times. Early formation time haloes are, at the present epoch, more spherical and have higher velocity dispersions than late forming-time haloes. The halo shape-dynamics correlation, albeit weaker, survives the projection in 2D (ie., among projected shape and 1-D velocity dispersion). A similar shape-dynamics correlation, independent of mass, is also found in the SDSS DR7 groups of galaxies and in order to investigate its cause we have tested and used, as a proxy of the group formation time, a concentration parameter. We have found, as in the case of the simulated haloes, that less concentrated groups, corresponding to late formation times, have lower velocity dispersions and higher elongations than groups with higher values of concentration, corresponding to early formation times.
description: MNRAS in press (10 pages, 10 figures)
Assessment of soil erosion risk in a typical Mediterranean environment using a high resolution RUSLE approach (Portofino promontory, NW-Italy)
Creators: name: Rellini, I.
name: Scopesi, C.
name: Olivari, S.
name: Firpo, M.
name: Maerker, M.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Particularly the Liguria region in Northern Italy is highly affected by soil erosion processes. This study was conducted in the Portofino promontory in eastern Liguria, to predict potential annual soil loss using the Revised Universal Soil Loss Equation (RUSLE). Moreover, we evaluate the relative accuracy of the predictions at detailed scale, using high resolution spatial information for model calibration. The RUSLE factors were calculated for the study area based on terrain survey data and rain gauge measurements. The results were plotted on a 1:10,000 scale soil erosion map and subsequently compared with the European soil loss estimation method (RUSLE2015) developed by the European Joined Research Centre. This study shows that the RUSLE2015 model can be applied in a typical Mediterranean environment such as the Portofino promontory. However, the accuracy of the single factors we calculated using high resolution data sets might improve the results substantially and thus, also model efficiency.
An orifice shape-based reduced order model of patient-specific mitral valve regurgitation
Creators: name: Franz, J.
name: Czechowicz, K.
name: Waechter-Stehle, I.
name: Hellmeier, F.
name: Razafindrazaka, F.
name: Kelm, M.
name: Kempfert, J.
name: Meyer, A.
name: Archer, G.
name: Weese, J.
name: Hose, R.
name: Kuehne, T.
name: Goubergrits, L.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Mitral valve regurgitation
subject: pressure gradient
subject: computational fluid dynamics
subject: regurgitant orifice area
subject: 3D transesophageal echocardiography
subject: patient-specific model
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mitral valve regurgitation (MR) is one of the most prevalent valvular heart diseases. Its quantitative assessment is challenging but crucial for treatment decisions. Using computational fluid dynamics (CFD), we developed a reduced order model (ROM) describing the relationship between MR flow rates, transvalvular pressure differences, and the size and shape of the regurgitant valve orifice. Due to its low computational cost, this ROM could easily be implemented into clinical workflows to support the assessment of MR. We reconstructed mitral valves of 43 patients from 3D transesophageal echocardiographic images and estimated the 3D anatomic regurgitant orifice areas using a shrink-wrap algorithm. The orifice shapes were quantified with three dimensionless shape parameters. Steady-state CFD simulations in the reconstructed mitral valves were performed to analyse the relationship between the regurgitant orifice geometry and the regurgitant hemodynamics. Based on the results, three ROMs with increasing complexity were defined, all of which revealed very good agreement with CFD results with a mean bias below 3% for the MR flow rate. Classifying orifices into two shape groups and assigning group-specific flow coefficients in the ROM reduced the limit of agreement predicting regurgitant volumes from 9.0 ml to 5.7 ml at a mean regurgitant volume of 57 ml.
MPEC 2023-X154 : 2023 XM4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 XM4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes
Creators: name: Reslan, Lina
name: Youssef, Nour
name: Boutros, Celina F.
name: Assaf-Casals, Aia
name: Fayad, Danielle
name: Khafaja, Sarah
name: Akl, Fata
name: Finianos, Marc
name: Rizk, Amena A.
name: Shaker, Rouba
name: Zaghlout, Alissar
name: Lteif, Mireille
name: Hafi, Bassam El
name: Moumneh, Mohammad Bahij
name: Feghali, Rita
name: Ghanem, Soha
name: Jisr, Tamima
name: Karayakoupoglou, Gilbert
name: Naboulsi, Malak
name: Hamze, Monzer
name: Samad, Salam
name: Khoury, Elie
name: Sarraf, Ricardo
name: Osman, Marwan
name: Raad, Elie Bou
name: Amin, Hadi El
name: Abadi, Ibrahim
name: Abdo, Hicham
name: Chedid, Marwan
name: Chamseddine, Fatima
name: Barakat, Angelique
name: Houmani, Mohammad
name: Haddad, Antoine
name: Nour, Georges Abdel
name: Mokhbat, Jacques E.
name: Daoud, Ziad
name: El-Zaatari, Mohamad
name: Sokhn, Elie Salem
name: Ghosn, Nada
name: Ammar, Walid
name: Hamadeh, Randa
name: Matar, Ghassan M.
name: Araj, George F.
name: #, Ghassan S. Dbaibo for the Lebanese Inter-Hospital Pneumococcal Surveillance Program investigators
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The impact of pneumococcal conjugate vaccines (PCVs) on the burden of invasive pneumococcal disease (IPD) and serotype distribution was examined across age groups from data collected by the Lebanese Inter-Hospital Pneumococcal Surveillance Program. Between 2005 and 2020, 593 invasive Streptococcus pneumoniae isolates were collected from 79 hospitals throughout Lebanon. Serotypes and antimicrobial resistance (AMR) profiles were identified, and trends compared over 3 eras: PCV7, post-PCV7/ pre-PCV13, and PCV13 eras. The prevalence of PCV7 serotypes decreased significantly from 43.6% in the PCV7 era to 17.8% during the PCV13 era (p<0.001). PCV13-only serotypes remained stable in the PCV13 compared to the post-PCV7 eras, especially serotypes 1 and 3, whereas non-vaccine types (NVT) increased throughout the study period, especially 24 and 16F. The mortality rate increased substantially from 12.5% (PCV7 era) to 24.8% (PCV13 era). A significant decrease in AMR was observed across the three study eras. PCVs substantially impacted IPD and AMR in vaccinated and unvaccinated populations despite an increase in mortality driven by NVT. Broadening the recommendation of vaccination to include older age-groups, using higher valency vaccines, and implementing stringent antimicrobial stewardship are likely to further impact the burden of IPD.
Projecting the Bethe-Salpeter Equation onto the Light-Front and back: A Short Review
Creators: name: Frederico, Tobias
name: Salme`, Giovanni
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The technique of projecting the four-dimensional two-body Bethe-Salpeter equation onto the three-dimensional Light-Front hypersurface, combined with the quasi-potential approach, is briefly illustrated, by placing a particular emphasis on the relation between the projection method and the effective dynamics of the valence component of the Light-Front wave function. Some details on how to construct the Fock expansion of both i) the Light-Front effective interaction and ii) the electromagnetic current operator, satisfying the proper Ward-Takahashi identity, will be presented, addressing the relevance of the Fock content in the operators living onto the Light-Front hypersurface. Finally, the generalization of the formalism to the three-particle case will be outlined.
description: 16 pages, macros included. Mini-review to be printed in a regular issue of Few-Body Systems devoted to the Workshop on "Relativistic Description of Two- and Three-body Systems in Nuclear Physics" ECT* Trento, 19 - 23 October 2009
Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria
Creators: name: Kolkhir, Pavel
name: Altrichter, Sabine
name: Asero, Riccardo
name: Daschner, Alvaro
name: Ferrer, Marta
name: Giménez-Arnau, Ana
name: Hawro, Tomasz
name: Jakob, Thilo
name: Kinaciyan, Tamar
name: Kromminga, Arno
name: Konstantinou, George N.
name: Makris, Michael
name: Metz, Martin
name: Skov, Per Stahl
name: Staubach, Petra
name: Sussman, Gordon
name: Zhang, Ke
name: Maurer, Marcus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Chronic urticaria
subject: autoimmune diseases
subject: autoimmune thyroiditis
subject: autoantibodies
subject: autoimmunity
subject: omalizumab
subject: vitiligo
subject: immunoassay
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. Methods: We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against Fc epsilon RI alpha/IgE detected by immunoassay. Results: Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (>= 21%) and vitiligo (2%). Two percent of CSU patients had >= 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism (P < 0.001). Presence of autoimmune diseases was linked to aiCSU (P = 0.02). The risks of having autoimmune diseases were 1.7, 2.9 and 3.3 times higher for CSU patients with a positive ASST, BHRA and BAT, respectively. In CSU patients, markers for autoimmune diseases, antinuclear antibodies and/or IgG anti-thyroid antibodies were associated with non-response to omalizumab treatment (P = 0.013). Conclusions: In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo.
Dynophore-Based Approach in Virtual Screening: A Case of Human DNA Topoisomerase IIα
Creators: name: Janežič, Matej
name: Valjavec, Katja
name: Loboda, Kaja Bergant
name: Herlah, Barbara
name: Ogris, Iza
name: Kozorog, Mirijam
name: Podobnik, Marjetka
name: Grdadolnik, Simona Golič
name: Wolber, Gerhard
name: Perdih, Andrej
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: human DNA topoisomerase IIα
subject: catalytic inhibitors
subject: dynophore models
subject: drug design
subject: molecular simulations
subject: cancer research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: In this study, we utilized human DNA topoisomerase IIα as a model target to outline a dynophore-based approach to catalytic inhibitor design. Based on MD simulations of a known catalytic inhibitor and the native ATP ligand analog, AMP-PNP, we derived a joint dynophore model that supplements the static structure-based-pharmacophore information with a dynamic component. Subsequently, derived pharmacophore models were employed in a virtual screening campaign of a library of natural compounds. Experimental evaluation identified flavonoid compounds with promising topoisomerase IIα catalytic inhibition and binding studies confirmed interaction with the ATPase domain. We constructed a binding model through docking and extensively investigated it with molecular dynamics MD simulations, essential dynamics, and MM-GBSA free energy calculations, thus reconnecting the new results to the initial dynophore-based screening model. We not only demonstrate a new design strategy that incorporates a dynamic component of molecular recognition, but also highlight new derivates in the established flavonoid class of topoisomerase II inhibitors.
Alasdair MacIntyre, Charles Taylor, and the Demise of Naturalism: Reunifying Political Theory and Social Science
Creators: name: Blakely, Jason
Publisher: name: University of Notre Dame
Year: 2023

description: Today the ethical and normative concerns of everyday citizens are all too often sidelined from the study of political and social issues, driven out by an effort to create a more 'scientific' study. This book offers a way for social scientists and political theorists to reintegrate the empirical and the normative, proposing a way out of the scientism that clouds our age. In _Alasdair MacIntyre, Charles Taylor, and the Demise of Naturalism_, Jason Blakely argues that the resources for overcoming this divide are found in the respective intellectual developments of Charles Taylor and Alasdair MacIntyre. Blakely examines their often parallel intellectual journeys, which led them to critically engage the British New Left, analytic philosophy, phenomenology, continental hermeneutics, and modern social science. Although MacIntyre and Taylor are not _sui generis_, Blakely claims they each present a new, revived humanism, one that insists on the creative agency of the human person against reductive, instrumental, technocratic, and scientistic ways of thinking. The recovery of certain key themes in these philosophers' works generates a new political philosophy with which to face certain unprecedented problems of our age. Taylor's and MacIntyre's philosophies give social scientists working in all disciplines (from economics and sociology to political science and psychology) an alternative theoretical framework for conducting research.\u000a\u000a\u00A9 University of Notre Dame\u000a\u000aCopyright for most content is held by The University of Notre Dame. Reproduction of all or any portion of content constitutes a violation of copyright. You must obtain permission from The Copyright Clearance Center or The University of Notre Dame Press in order to reprint (or adapt) content.\u000a\u000ap: (574) 631-6346 \ e: undpress@nd\.edu \ website: copyright\.com
Cooperative scattering measurement of coherence in a spatially modulated Bose gas
Creators: name: Lu, Bo
name: Vogt, Thibault
name: Liu, Xinxing
name: Xu, Xu
name: Zhou, Xiaoji
name: Chen, Xuzong
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Correlations of a Bose gas released from an optical lattice are measured using superradiant scattering. Conditions are chosen so that after initial incident light pumping at the Bragg angle for diffraction, due to matter wave amplification and mode competition, superradiant scattering into the Bragg diffracted mode is preponderant. A temporal analysis of the superradiant scattering gain reveals periodical oscillations and damping due to the initial lack of coherence between lattice sites. Such damping is used for characterizing first order spatial correlations in our system with a precision of one lattice period.
description: 4pages, 3figures, to appear in Phys. Rev. A
Gas-like state of $α$ clusters around $^{16}$O core in $^{24}$Mg
Creators: name: Ichikawa, T.
name: Itagaki, N.
name: Kawabata, T.
name: Kokalova, Tz.
name: von Oertzen, W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We have studied gas-like states of $α$ clusters around an $^{16}$O core in $^{24}$Mg based on a microscopic $α$-cluster model. This study was performed by introducing a Monte Carlo technique for the description of the THSR (Tohsaki Horiuchi Schuck Röpke) wave function, and the coupling effect to other low-lying cluster states was taken into account. A large isoscalar monopole ($E0$) transition strength from the ground to the gas-like state is discussed. The gas-like state of two $α$ clusters in $^{24}$Mg around the $^{16}$O core appears slightly below the 2$α$-threshold e
description: submitted to Phys. Rev. C
Dementia Awareness Challenges in Sub-Saharan Africa: A Cross-Sectional Survey Conducted Among School Students in Ghana
Creators: name: Spittel, Susanne
name: Kraus, Elke
name: Maier, André
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: dementia awareness
subject: knowledge
subject: Sub-Saharan Africa
subject: belief in witchcraft
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The survey focuses on identifying dementia awareness challenges among Ghanaian school students. Data were generated in a cross-sectional survey (n = 1137). 9.3% of school students showed dementia awareness whilst the community respondents, representing both higher age and level of education, showed greater awareness (32.2%, P < .001). 45% of respondents believed in witchcraft and 57% were afraid of potentially being harmed by witchcraft. Age and education did not influence people's belief in witchcraft. Moreover, dementia symptoms were often mistaken for witchcraft, especially by those who had encountered a person accused of witchcraft: "swearing at others" (24%), displaying "memory loss" and "confused speech" (22%), "forgetfulness" and who was seen "roaming around" (19%). Lack of dementia awareness was particularly evident among school students whereas belief in witchcraft was similar in both respondent groups. There was a correlation between low dementia awareness rates and misinterpretation of dementia symptoms with attribution to witchcraft.
The role of pressure on the magnetism of bilayer graphene
Creators: name: Castro, Eduardo V.
name: López-Sancho, María P.
name: Vozmediano, María A. H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We study the effect of pressure on the localized magnetic moments induced by vacancies in bilayer graphene in the presence of topological defects breaking the bipartite nature of the lattice. By using a mean-field Hubbard model we address the two inequivalent types of vacancies that appear in the Bernal stacking bilayer graphene. We find that by applying pressure in the direction perpendicular to the layers the critical value of the Hubbard interaction needed to polarize the system decreases. The effect is particularly enhanced for one type of vacancies, and admits straightforward generalization to multilayer graphene in Bernal stacking and graphite. The present results clearly demonstrate that the magnetic behavior of multilayer graphene can be affected by mechanical transverse deformation.
MutationTaster2021
Creators: name: Steinhaus, Robin
name: Proft, Sebastian
name: Schuelke, Markus
name: Cooper, David N.
name: Schwarz, Jana Marie
name: Seelow, Dominik
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Disease
subject: Phenotype
subject: RNA Splice Sites
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Here we present an update to MutationTaster, our DNA variant effect prediction tool. The new version uses a different prediction model and attains higher accuracy than its predecessor, especially for rare benign variants. In addition, we have integrated many sources of data that only became available after the last release (such as gnomAD and ExAC pLI scores) and changed the splice site prediction model. To more easily assess the relevance of detected known disease mutations to the clinical phenotype of the patient, MutationTaster now provides information on the diseases they cause. Further changes represent a major overhaul of the interfaces to increase user-friendliness whilst many changes under the hood have been designed to accelerate the processing of uploaded VCF files. We also offer an API for the rapid automated query of smaller numbers of variants from within other software. MutationTaster2021 integrates our disease mutation search engine, MutationDistiller, to prioritise variants from VCF files using the patient's clinical phenotype. The novel version is available at https://www.genecascade.org/MutationTaster2021/. This website is free and open to all users and there is no login requirement.
Surface ruptures following the 26 December 2018, Mw 4.9, Mt. Etna earthquake, Sicily (Italy)
Creators: name: Civico, Riccardo
name: Pucci, Stefano
name: Nappi, Rosa
name: Azzaro, Raffaele
name: Villani, Fabio
name: Pantosti, Daniela
name: Cinti, Francesca R.
name: Pizzimenti, Luca
name: Branca, Stefano
name: Brunori, Carlo Alberto
name: Caciagli, Marco
name: Cantarero, Massimo
name: Cucci, Luigi
name: D’Amico, Salvatore
name: De Beni, Emanuela
name: De Martini, Paolo Marco
name: Mariucci, Maria Teresa
name: Montone, Paola
name: Nave, Rosella
name: Ricci, Tullio
name: Sapia, Vincenzo
name: Smedile, Alessandra
name: Tarabusi, Gabriele
name: Vallone, Roberto
name: Venuti, Alessandra
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Computational Biology

description: We present a 1:10,000 scale map of the coseismic surface ruptures following the 26 December 2018 Mw 4.9 earthquake that struck the eastern flank of Mt. Etna volcano (southern Italy). Detailed rupture mapping is based on extensive field surveys in the epicentral region. Despite the small size of the event, we were able to document surface faulting for about 8 km along the trace of the NNW-trending active Fiandaca Fault, belonging to the Timpe tectonic system in the eastern flank of the volcano. The mapped ruptures are characterized in most cases by perceivable opening and by a dominant right-oblique sense of slip, with an average slip of about 0.09 m and a peak value of 0.35 m. It is also noteworthy that the ruptures vary significantly in their kinematic expression, denoting locally high degree of complexity of the surface faulting.
Correlation Time-of-flight Spectrometry of Ultracold Neutrons
Creators: name: Novopoltsev, M. I.
name: Pokotilovski, Yu. N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The fearures of the correlation method used in time-of-flight spectrometry of ultracold neutrons are analyzed. The time-of-flight spectrometer for the energy range of ultracold neutrons is described, and results of its testing by measuring spectra of neutrons passing through interference filters are presented.
description: 16 pages, 5 figures
Effects of weathering on chemical and mineralogical properties of the Mount Polley mine tailings : preliminary implications for long-term ecosystem health
Creators: name: Evans, Elana
Publisher: name: University of British Columbia
Year: 2018

description: The Mount Polley Mine’s tailings storage facility failure deposited large amounts of relatively unweathered material of a range of mineralogical and chemical composition over the Hazeltine Creek channel in Secwepemc territory. Reclamation efforts focus on the present chemical composition and sequential extractability of metals in the tailings. This precursory research focuses on the surface reactions of the tailings material and the effect that acids have on altering surface chemistry of these fresh tailings deposits in relation to environmental risk standards. Through laboratory simulation experiments, acid ammonium oxalate, hydrochloric acid, and aqua regia treatments, tailings composition under simulated acid weathered conditions were examined. The deposited tailings are characterized by low aeration and porosity, alkaline pH and very limited organic matter. Cu and V were readily available in concentrations that exceed the CSR regulations for the protection of soil invertebrates and plants. Exploratory PCA analysis suggested that the chemical composition of the tailings is not depth dependent, but spatial and material segregations were evident. XRD diagrams of tailings under simulated weathering conditions illustrate that the material has variable susceptibility to weathering. Calcite, magnetite and chlorite group minerals were removed by acid ammonium oxalate and hydrochloric acid treatments, while the more stable feldspar group minerals (albite, microcline), muscovite and quartz persisted despite treatment with the strong acid, aqua regia. Apatite group minerals were found in the majority of the raw samples. Elemental analysis revealed high concentrations of extractable P in the tailings. Longer-term monitoring of the receiving aquatic environments is recommended. Removal of tailings from the Hazeltine Creek channel is encouraged as is combining remnant tailings with organic material and till to improve aeration, porosity and structure, promote metal complexation and provide N for re-vegetation.
Chronology of the Basalt Units Surrounding Chang’e-4 Landing Area
Creators: name: Yue, Zongyu
name: Shi, Ke
name: Michael, Gregory
name: Di, Kaichang
name: Gou, Sheng
name: Liu, Jianzhong
name: Niu, Shengli
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: lunar chronology
subject: basalt units
subject: CE-4 landing area
subject: absolute model age
subject: crater sizefrequency distribution (CSFD)
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: The Chang’e-4 (CE-4) lunar probe, the first soft landing spacecraft on the far side of the Moon, successfully landed in the Von Kármán crater on 3 January 2019. Geological studies of the landing area have been conducted and more intensive studies will be carried out with the in situ measured data. The chronological study of the maria basalt surrounding the CE-4 landing area is significant to the related studies. Currently, the crater size-frequency distribution (CSFD) technique is the most popular method to derive absolute model ages (AMAs) of geological units where no returned sample is available, and it has been widely used in dating maria basalt on the lunar surface. In this research, we first make a mosaic with multi-orbital Chang’e-2 (CE-2) images as a base map. Coupled with the elevation data and FeO content, nine representative areas of basalt units surrounding the CE-4 landing area are outlined and their AMAs are derived. The dating results of the nine basalt units indicate that the basalts erupted from 3.42 to 2.28 Ga ago in this area, a period much longer than derived by previous studies. The derived chronology of the above basalt units establishes a foundation for geological analysis of the returned CE-4 data.
The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes
Creators: name: Reslan, Lina
name: Youssef, Nour
name: Boutros, Celina F.
name: Assaf-Casals, Aia
name: Fayad, Danielle
name: Khafaja, Sarah
name: Akl, Fata
name: Finianos, Marc
name: Rizk, Amena A.
name: Shaker, Rouba
name: Zaghlout, Alissar
name: Lteif, Mireille
name: Hafi, Bassam El
name: Moumneh, Mohammad Bahij
name: Feghali, Rita
name: Ghanem, Soha
name: Jisr, Tamima
name: Karayakoupoglou, Gilbert
name: Naboulsi, Malak
name: Hamze, Monzer
name: Samad, Salam
name: Khoury, Elie
name: Sarraf, Ricardo
name: Osman, Marwan
name: Raad, Elie Bou
name: Amin, Hadi El
name: Abadi, Ibrahim
name: Abdo, Hicham
name: Chedid, Marwan
name: Chamseddine, Fatima
name: Barakat, Angelique
name: Houmani, Mohammad
name: Haddad, Antoine
name: Nour, Georges Abdel
name: Mokhbat, Jacques E.
name: Daoud, Ziad
name: El-Zaatari, Mohamad
name: Sokhn, Elie Salem
name: Ghosn, Nada
name: Ammar, Walid
name: Hamadeh, Randa
name: Matar, Ghassan M.
name: Araj, George F.
name: investigators, Ghassan S. Dbaibo for the Lebanese Inter-Hospital Pneumococcal Surveillance Program
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The impact of pneumococcal conjugate vaccines (PCVs) on the burden of invasive pneumococcal disease (IPD) and serotype distribution was examined across age groups from data collected by the Lebanese Inter-Hospital Pneumococcal Surveillance Program. Between 2005 and 2020, 593 invasive Streptococcus pneumoniae isolates were collected from 79 hospitals throughout Lebanon. Serotypes and antimicrobial resistance (AMR) profiles were identified, and trends compared over 3 eras: PCV7, post-PCV7/ pre-PCV13, and PCV13 eras. The prevalence of PCV7 serotypes decreased significantly from 43.6% in the PCV7 era to 17.8% during the PCV13 era (p<0.001). PCV13-only serotypes remained stable in the PCV13 compared to the post-PCV7 eras, especially serotypes 1 and 3, whereas non-vaccine types (NVT) increased throughout the study period, especially 24 and 16F. The mortality rate increased substantially from 12.5% (PCV7 era) to 24.8% (PCV13 era). A significant decrease in AMR was observed across the three study eras. PCVs substantially impacted IPD and AMR in vaccinated and unvaccinated populations despite an increase in mortality driven by NVT. Broadening the recommendation of vaccination to include older age-groups, using higher valency vaccines, and implementing stringent antimicrobial stewardship are likely to further impact the burden of IPD.
Dynamical versus Stellar Masses of Ultracompact Dwarf Galaxies in the Fornax Cluster
Creators: name: Chilingarian, Igor
name: Mieske, Steffen
name: Hilker, Michael
name: Infante, Leopoldo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The origin of ultracompact dwarf (UCD) galaxies, compact extragalactic stellar systems, is still a puzzle for present galaxy formation models. We present the comprehensive analysis of high resolution multi-object spectroscopic data for a sample of 24 Fornax cluster UCDs obtained with VLT FLAMES. It comprises previously published data for 19 objects (Mieske et al. 2008) which we re-analysed, including 13 with available HST photometric data. Using Virtual Observatory technologies we found archival HST images for two more UCDs and then determined their structural properties. For all objects we derived internal velocity dispersions, stellar population parameters, and stellar mass-to-light ratios (M/L)* by fitting individual simple stellar population (SSP) synthetic spectra convolved with a Gaussian against the observed spectra using the NBursts full spectral fitting technique. For 14 objects we estimated dynamical masses suggesting no dark matter (DM) in 12 of them and no more than 40 per cent DM mass fraction in the remaining two, in contrast to findings for several UCDs in the Virgo cluster. Some Fornax UCDs even have too high values of (M/L)* estimated using the Kroupa stellar initial mass function (IMF) resulting in negative formally computed DM mass fractions. The objects with too high (M/L)* ratios compared to the dynamical ones have relatively short dynamical relaxation timescales, close to the Hubble time or below. We therefore suggest that their lower dynamical ratios (M/L)dyn are caused by low-mass star depletion due to dynamical evolution. Overall, the observed UCD characteristics suggest at least two formation channels: tidal threshing of nucleated dwarf galaxies for massive UCDs (~10^8 M_sun), and a classical scenario of red globular cluster formation for lower-mass UCDs (< 10^7 M_sun).
description: Accepted for publication in MNRAS; 13 pages, 9 figures, 2 tables
Links of Perceived Pornography Realism with Sexual Aggression via Sexual Scripts, Sexual Behavior, and Acceptance of Sexual Coercion: A Study with German University Students
Creators: name: Krahé, Barbara
name: Tomaszewska, Paulina
name: Schuster, Isabell
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: pornography use
subject: realism
subject: sexual aggression
subject: sexual victimization
subject: sexual scripts
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::370 Bildung und Erziehung
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Exposure to pornographic material has been linked to sexual aggression perpetration and victimization in a large body of research. Based on social learning theory and 3A theory of script learning, this study contributes to this research by testing the hypothesis that the more realistic pornography is perceived to be by young adults, the more likely they are to experience and engage in sexual aggression. Two underlying pathways were proposed: one path via scripts and patterns of sexual behavior regarding consensual sexual interactions that contain established risk factors for sexual aggression victimization and perpetration, and a second path via the acceptance of sexual coercion. In a cross-sectional study, 1181 university students in Germany (762 female; 419 male) completed measures of pornography use and perception, risky sexual scripts and sexual behavior, and acceptance of sexual coercion. As predicted, pornography realism was a positive predictor of risky sexual scripts, risky sexual behavior, and acceptance of sexual coercion. Indirect links with sexual aggression victimization and perpetration were found via both pathways. No gender differences in the associations were found. The implications for media literacy interventions addressing the realism of pornography are discussed
Patients’ and Health Care Workers’ Perception of Migraine Images on the Internet: Cross-sectional Survey Study
Creators: name: Raffaelli, Bianca
name: Kull, Pia
name: Mecklenburg, Jasper
name: Overeem, Lucas Hendrik
name: Storch, Elisabeth
name: Terhart, Maria
name: Neeb, Lars
name: Reuter, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: migraine
subject: stigma
subject: mass media
subject: stock photos
subject: advocacy
subject: internet
subject: perception
subject: headache
subject: pain
subject: cross-sectional
subject: survey
subject: stereotype
subject: media
subject: awareness
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The representation of migraine in the media is stereotypical. Standard images of migraine attacks display stylish young women holding their head in a pain pose. This representation may contribute to the social stigmatization of patients with migraine. Objective: We aimed to analyze how patients with migraine and health care workers perceive online images of migraine. Methods: The study consisted of an anonymous web-based survey of patients with migraine at the Headache Center of Charite - Universitatsmedizin Berlin (migraine group) and employees and students at our university (health care group). A total of 10 frequently used Adobe Stock photos of migraine attacks were presented to the participants. Each photo was rated on a scale of 0% to 100% based on how closely it resembled a realistic migraine attack (realism score). Patients with migraine also indicated how much each photo corresponded to their own experience of migraine as a percentage (representation score). We calculated the mean realism and representation scores for all photos and conducted further analyses using the categories male or female models, younger or older models, and unilateral or bilateral pain pose. Results: A total of 367 patients with migraine and 331 health care employees and students completed the survey. In both groups, the mean realism score was <50% (migraine group: 47.8%, SD 18.3%; health care group: 46.0%, SD 16.2%). Patients with migraine identified their own migraine experience in these photos to a lesser degree (mean representation score 44.4%, SD 19.8%; P
Geomorphology of the Upper General River Basin, Costa Rica
Creators: name: Quesada-Román, Adolfo
name: Zamorano-Orozco, José Juan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: In spite of the geomorphological diversity of Central America and Costa Rica, there are few detailed geomorphological maps. A 1:25,000 scale map of the Upper General River Basin (UGRB) in Costa Rica is presented, based on the interpretation of aerial photographs and field geomorphological mapping. A total of 43 types of landforms divided genetically into endogenic (tectonic features), and exogenic (fluvial, gravitational, and glacial features) are mapped for an area of 1560 km2. This cartography is important in terms of disaster prevention and mitigation (floods and hillslope processes), as well as for land use planning.
The Persistence of The Impact of COVID-19-Related Distress, Mood Inertia and Loneliness on Mental Health During a Postlockdown Period in Germany: An Ecological Momentary Assessment Study
Creators: name: Haucke, Matthias
name: Liu, Shuyan
name: Heinzel, Stephan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: COVID-19
subject: outbreaks
subject: epidemics
subject: pandemics
subject: psychological responses and emotional well-being
subject: ecological momentary assessment
subject: risk and protective factors
subject: low incidence and restrictions
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The first wave of the COVID-19 pandemic in early 2020 increased mental health problems globally. However, little is known about mental health problems during a low-incidence period of the pandemic without strict public health measures. Objective: We aim to investigate whether COVID-19-related risk factors for mental health problems persist beyond lockdown measures. We targeted a vulnerable population that is at risk of developing low mental health and assessed their daily dynamics of mood and emotion regulation after a strict lockdown. Methods: During a postlockdown period in Germany (between August 8, 2020, and November 1, 2020), we conducted an ecological momentary assessment with 131 participants who experienced at least mild COVID-19-related distress and loneliness. To estimate negative mood inertia, we built a lag-1 three-level autoregressive model. Results: We found that information exposure and active daily COVID-19 cases did not have an impact on negative mood amid a postlockdown period. However, there was a day-to-day carryover effect of negative mood. In addition, worrying about COVID-19, feeling restricted by COVID-19, and feeling lonely increased negative mood. Conclusions: The mental health of a vulnerable population is still challenged by COVID-19-related stressors after the lifting of a strict lockdown. This study highlights the need to protect mental health during postpandemic periods.