Additional file 1 of Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort study in the UK Biobank
Creators: name: Zeng, Liangtang
name: Wu, Zhuo
name: Yang, Jiabin
name: Zhou, Yu
name: Chen, Rufu
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Virology

description: Additional file 1: Table S1. Data fields and International Classification of Disease Codes used for identification of PC and date of PC diagnosis in the UK Biobank cohort. Table S2. Data fields and information on variables in the UK Biobank cohort involved in this study. Table S3. The breakdown of the missing data for the lifestyle factors and other covariates. Table S4. Information on SNPs used to construct PRS 54 for pancreatic cancer. Table S5. Information on SNPs used to construct PRS 22 for pancreatic cancer. Table S6. Information on SNPs used to construct PRS 32 for pancreatic cancer. Table S7. Unweighted healthy lifestyle score components. Table S8. Baseline characteristics between female and male in the UK Biobank. Table S9. Sex-specific weighted healthy lifestyle score components. Table S10. Baseline characteristics of participants of PC in the UK Biobank. Table S11. Associations between lifestyle components and PC. Table S12. Combined association between PRS, weighted healthy lifestyle score, and PC. Table S13. Combined association between PRS, unweighted healthy lifestyle score, and PC. Table S14. Combined association between PRS, lifestyle components, and PC. Table S15. The absolute risk reductions of pancreatic cancer in different PRS. Table S16. Multivariable Cox regression analysis of genetic risk and lifestyles in relation to risk of PC, stratified by age. Table S17. Multivariable Cox regression analysis of lifestyle components in relation to risk of PC, stratified by age. Table S18. Multivariable Cox regression analysis of genetic risk and lifestyles in relation to risk of PC, stratified by sex. Table S19. Multivariable Cox regression analysis of lifestyle components in relation to risk of PC, stratified by sex. Table S20. The absolute risk reduction of pancreatic cancer in various age and sex groups. Table S21. The additive interaction between lifestyles and PRS (RERI). Table S22. The additive interaction between lifestyles, or PRS, and age (RERI). Table S23. The additive interaction between lifestyles, or PRS, and sex (RERI). Table S24. Associations between lifestyles, PRS, and PC after excluding the incidence of PC or death during the first 2 years of follow-up. Table S25. Combined analysis of PRS and lifestyles on the risk of PC in participants after excluding the incidence of PC or death during the first 2 years of follow-up. Table S26. Associations between lifestyles, PRS, and PC using competing risk analysis. Table S27. Combined analysis of PRS and lifestyle components on the risk of PC using competing risk analysis. Fig. S1. ROC curves and density plots of PRS and healthy lifestyle score. Fig. S2. Cumulative risk of PC by the joint effect of lifestyle and PRS. Fig. S3. ROC curves and AUC metrics of PRS and HLSs according to different age groups.