cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IUPHAR/BPS guide to pharmacology
Creators: name: Harding, Simon D.
name: Armstrong, Jane F.
name: Faccenda, Elena
name: Pawson, Adam J.
name: Southan, Christopher
name: Alexander, Stephen P.H.
name: Davenport, Anthony P.
name: Spedding, Michael
name: Davies, Jamie A.
name: NC-IUPHAR
Publisher: name: F1000 Research Limited
Year: 2020

description: The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an open, expert-driven database of pharmacological targets and the substances that act on them. It is a joint initiative between the British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR), which aims to cover the human targets of licensed drugs and other likely targets of future therapeutics.

This poster give an update on the recent activities of GtoPdb, including details of our coronavirus pharmacology information page.
Services and tools for mammalian genotype and phenotype data integration and comparison
Creators: name: Rowlands, Thomas
name: Shorter, Tom
name: Brookes, Anthony J.
name: Beck, Tim
Publisher: name: F1000 Research Limited
Year: 2020

description: GWAS Central represents the world’s largest collection of summary-level GWAS data. It consists of a deep and descriptive data model, that is either manually populated by researchers, reading GWAS papers in a process that is inevitably time consuming and error prone, or by importing a ‘thin layer’ of data from other public databases. As a result, potentially significant information hidden within the full text of a study can be lost, potentially through exclusion from a manual import by the authors or the ‘thin layer’ imported which simply contains summary level data.

By developing an NLP pipeline capable of extracting key GWAS concepts, we will be able to increase the level of detail provided by GWAS Central and expand the number of studies processed & stored, all while mapping identified terms to popular bio-ontologies such as MeSH & HPO. The end goal for this NLP solution will be to remove the need for human micromanagement of new GWAS study data, continuously importing new studies as and when they become available, processing them automatically and improving the amount of meaningful metadata provided by each study through linking key semantic terms.

Further along in development, we will be able to automatically identify genes/variants and phenotypes of interest, allowing integrated distributed searches across genotype and phenotype public resources such as ELIXIR Beacon, UKCRC Tissue Directory, GWAS Central & EBI ensemble. This will be achieved through the integration of available APIs and SPARQL endpoints, giving researchers access to these resources from a centralized web location using a single user interface.

In addition to these improvements, we also plan to integrate GWAS data with mouse gene knockout studies from the International Mouse Phenotyping Consortium, aligning human genetic variants with mouse genes and mapping human & mouse phenotypes. Once this work is completed, researchers will be able to compare mouse genetic variants causing a phenotype, with the potential of identifying human genetic variants responsible for this phenotype for further research.

Finally, we present progress made in autonomously extracting meaningful data from the full text of GWAS studies, consisting primarily of phenotypes, SNPs, author details and identifiers. In addition, we give an insight into our future development plans for the improvement of GWAS Central and how this will benefit genetics research.
Bondoc-Nachlese
Creators: name: Werning, Rainer
Publisher: name: südostasien informationen
Year: 2019

description: Tatsache ist, daß die fragliche Studie längere Interviews mit den verantwortlichen Philippinen-Länderreferenten des BMZ und der GTZ (Deutsche Gesellschaft für Technische Zusammenarbeit) enthält, die diese dem Autor im September 1995 gewährt und in denen sie ihm gegenüber zugesagt hatten, unbeantwortet gebliebenen Fragen auf den Grund zu gehen. Bislang ist diese Zusage nicht eingelöst worden.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Additional file 1 of The effect of phenotyping, adult selection, and mating strategies on genetic gain and rate of inbreeding in black soldier fly breeding programs
Creators: name: Slagboom, Margot
name: Nielsen, Hanne Marie
name: Kargo, Morten
name: Henryon, Mark
name: Hansen, Laura Skrubbeltrang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Title: Effect of number of phenotyped larvae on genetic gain per generation for all breeding schemes. The number of preselected larvae was 400.Description: Table showing genetic gain per generation for different number of phenotyped larvae per breeding scheme, for 400 preselected larvae.
Gesichter haben sich geändert, die Strukturen nicht
Creators: name: Hansen, Sven
Publisher: name: südostasien informationen
Year: 2019

description: Vor zehn Jahren, am 25. Februar 1986, stürzte der langjährige philippinische Diktator Ferdinand Marcos auf spektakuläre Weise: Nach gefälschten Wahlen kam es im sich anbahnenden Massenprotest zum Militärputsch. Eine mehrere hunderttausend umfassende, friedliche Menschenmenge folgte dem Aufruf des katholischen Jaime Kardinal Sin und schützte die Putschisten, während hinter den Kulissen die US-Regierung Marcos zur Aufgabe überredete. Damit war der Weg frei für "Cory" Aquino, in die große Hoffnungen gesetzt wurden.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Seasonal variation in geographical access to maternal health services in regions of southern Mozambique
Creators: name: Makanga, Prestige T
name: Schuurman, Nadine
name: Sacoor, Charfudin
name: Boene, Helena E
name: Vilanculo, Faustino
name: Vidler, Marianne
name: Magee, Laura
name: Von Dadelszen, Peter
name: Sevene, Esperança
name: Munguambe, Khátia
name: Firoz, Tabassum
Publisher: name: BioMed Central
Year: 2018

description: Background: Geographic proximity to health facilities is a known determinant of access to maternal care. Methods of quantifying geographical access to care have largely ignored the impact of precipitation and flooding. Further, travel has largely been imagined as unimodal where one transport mode is used for entire journeys to seek care. This study proposes a new approach for modeling potential spatio-temporal access by evaluating the impact of precipitation and floods on access to maternal health services using multiple transport modes, in southern Mozambique. Methods: A facility assessment was used to classify 56 health centres. GPS coordinates of the health facilities were acquired from the Ministry of Health while roads were digitized and classified from high-resolution satellite images. Data on the geographic distribution of populations of women of reproductive age, pregnancies and births within the preceding 12 months, and transport options available to pregnant women were collected from a household census. Daily precipitation and flood data were used to model the impact of severe weather on access for a 17-month timeline. Travel times to the nearest health facilities were calculated using the closest facility tool in ArcGIS software. Results: Forty-six and 87 percent of pregnant women lived within a 1-h of the nearest primary care centre using walking or public transport modes respectively. The populations within these catchments dropped by 9 and 5% respectively at the peak of the wet season. For journeys that would have commenced with walking to primary facilities, 64% of women lived within 2 h of life-saving care, while for those that began journeys with public transport, the same 2-hour catchment would have contained 95% of the women population. The population of women within two hours of life-saving care dropped by 9% for secondary facilities and 18% for tertiary facilities during the wet season. Conclusions: Seasonal variation in access to maternal care should not be imagined through a dichotomous and static lens of wet and dry seasons, as access continually fluctuates in both. This new approach for modelling spatio-temporal access allows for the GIS output to be utilized not only for health services planning, but also to aid near real time community-level delivery of maternal health services.
Additional file 1 of Deciphering the dynamics and trophic mode distribution of the leaf spot-associated fungal community of eggplant (Solanum melongena L.)
Creators: name: Kaniyassery, Arya
name: Sathish, Sudhanva Bhimanakatte
name: Thorat, Sachin Ashok
name: Murali, Thokur Sreepathy
name: Rao, Mattu Radhakrishna
name: Muthusamy, Annamalai
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Supplementary Material 1: Figure S1. Macroscopic and microscopic characteristics of fungi isolated from the leaf spot of the eggplant Mattu Gulla. The upper surface of the fungi is shown in the top panels. a. AKMG1 to a. AKMG18. The microscopy images shown in panels b1 to b18 were taken at 40X with a scale of 20 μm. Figure S2. The Rarefaction curve plot showing the species richness of the samples from the three different field locations studied. Samples 1 to 3 represented asymptomatic group from field locations 1, 2, and 3, respectively; Samples 4 to 6 represented symptomatic group from field locations 1, 2, and 3, respectively. Figure S3. Heatmap for the prediction of the top 30 MetaCyc pathways per category of functional composition of the microbial community metagenome from its ITS profiles. The data are presented as the relative abundance per sample for the symptomatic and asymptomatic groups. F1S, F2S, and F3S represented Symptomatic group samples from field locations 1, 2, and 3, respectively. Figure S4. Experimental design followed for the collection of leaf samples for microbiome profiling using NGS. Samples were collected from three fields at different locations. Three plots were considered from each field location. Triplicate sampling was performed from each plot with three symptomatic and three asymptomatic leaves. Asymptomatic and symptomatic leaves collected from each field location were separately pooled to obtain one sample for further analysis. Figure S5. Sequence quality histograms. a The mean quality value across each base position in the read. b The number of reads with average quality scores. c The percentage of base calls at each position for which an N was called.
Gegen den indonesischen Minister Habibie Klage vor deutschem Gericht eingereicht
Creators: name: Busch, Saskia
Publisher: name: südostasien informationen
Year: 2019

description: Auf Widerruf und Unterlassung - vorgeschlagener Streitwert: 6.000 DM - hat der infoladen, Conni e.V., den indonesischen Forschungs- und Technologieminister Habibie verklagt.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Bericht des Vorstandes an die 12. Mitgliederversammlung am 10.2.96 in Essen
Creators: name: Schmidt, Frithjof
Publisher: name: südostasien informationen
Year: 2019

description: Das erste Jahr der Südostasien Informationsstelle im Asienhaus geht zu Ende. Nach der großen Kraftanstrengung des Umzugs, der Freude über den Erfolg, dieses Projekt realisiert zu haben, trat eine Phase des neuen Alltags ein. Die praktischen Probleme der neuen Kooperationstrukturen, verbunden auch mit einer Reihe von Rückschlägen bei der Finanzierung unserer Arbeit, standen im Vordergrund der Tätigkeit des geschäftsführenden Vorstandes. Eine Grundsatzdiskussion über die Bilanzierung der bisherigen Arbeit der Südostasien Informationsstelle, die Möglichkeiten neuer Wege der Finanzierung, die Erfordernisse einer gezielten Schwerpunktsetzung und die gemeinsamen Perspektiven der Gruppen im Projekt Asienhaus wurde im Gesamtvorstand begonnen.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Metabolism of airborne methyl salicylate in adjacent plants
Creators: name: Rishni Masimbula
name: Oki, Katsunari
name: Takahashi, Kosaku
name: Matsuura, Hideyuki
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Salicylic acid (SA) and methyl salicylate (MeSA) are synthesized in many plants and are crucial components that establish their disease responses. The metabolism of airborne MeSA to SA has been previously reported. In this report, it was found that SA glucose ester (SAGE), ether (SAG), and salicyloyl-L-aspartic acid (SA-Asp) are metabolites of airborne MeSA. Furthermore, it was found that airborne MeSA was able to increase the endogenous amount of rosmarinic acid in Perilla frutescens, which is known as one of the functional components that contributes to the maintenance of human health. Metabolism of airborne methyl salicylate.
Deep-diving in NLP enhanced digitised newspapers. A hands-on session with the impresso interface
Creators: name: Bunout, Estelle
name: Ehrmann, Maud
name: During, Marten
Publisher: name: Zenodo
Year: 2020
Subjects: digitised newspapers

description: Abstract for a hands-on presentation of the impresso interface, dedicated to enable critical text mining of newspaper archives with the implementation of a technological framework to extract, process, link, and explore data from print media archives. Supported by a consortium composed of computational linguists, digital humanists, designers, historians, librarians and archivists, impresso (i.e. “what has been printed”) will tackle the challenges of content enrichment and data representation, visualization and analysis, completed by methodological and epistemological reflections.
Additional file 8 of Intolerance of uncertainty and repetitive negative thinking: transdiagnostic moderators of perfectionism in eating disorders
Creators: name: Hyde-Smith, Craig
name: Carey, Holly
name: Steward, Trevor
Publisher: name: figshare
Year: 2024
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Supplementary Material 8
Lysophosphatidic acid acyltransferase from the thermophilic bacterium Thermus thermophilus HB8 displays substrate promiscuity
Creators: name: Ogawa, Takuya
name: Nittikarn Suwanawat
name: Toyotake, Yosuke
name: Bunta Watanabe
name: Kawamoto, Jun
name: Kurihara, Tatsuo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Lysophosphatidic acid acyltransferase is a phospholipid biosynthetic enzyme that introduces a fatty acyl group into the sn-2 position of phospholipids. Its substrate selectivity is physiologically important in defining the physicochemical properties of lipid membranes and modulating membrane protein function. However, it remains unclear how these enzymes recognize various fatty acids. Successful purification of bacterial lysophosphatidic acid acyltransferases (PlsCs) was recently reported and has paved a path for the detailed analysis of their reaction mechanisms. Here, we purified and characterized PlsC from the thermophilic bacterium Thermus thermophilus HB8. This integral membrane protein remained active even after solubilization and purification and showed reactivity toward saturated, unsaturated, and methyl-branched fatty acids, although branched-chain acyl groups are the major constituent of phospholipids of this bacterium. Multiple sequence alignment revealed the N-terminal end of the enzyme to be shorter than that of PlsCs with defined substrate selectivity, suggesting that the shortened N-terminus confers substrate promiscuity. ACP: acyl carrier protein; CAPS: N-cyclohexyl-3-aminopropanesulfonic acid; CoA: coenzyme A; CYMAL-6: 6-cyclohexyl-1-hexyl-β-D-maltoside; DDM: n-dodecyl-β-D-maltoside; DTNB: 5,5´-dithiobis(2-nitrobenzoic acid); EPA: eicosapentaenoic acid; G3P: glycerol 3-phosphate; HEPES: N-2-hydroxyethylpiperazine-N´-2-ethanesulfonic acid; LPA: lysophosphatidic acid; MS: mass spectrometry; PA: phosphatidic acid. Lysophosphatidic acid acyltransferase from Thermus thermophilus was successfully purified in its active form and shown to have substrate promiscuity
Buchbesprechung: Karl Rössel: Operation Bondoc - Deutsche Entwicklungshilfe zur Aufstandsbekämpfung
Creators: name: Hansen, Sven
Publisher: name: südostasien informationen
Year: 2019

description: Vernichtende Kritik an einem der größten deutschen Entwicklungsprojekte in den Philippinen übt das Buch "Operation Bondoc - Deutsche Entwicklungshilfe zur Aufstandsbekämpfung" von Karl Rössel. Der Kölner Journalist wirft den Verantwortlichen im Bundesministerium für wirtschaftliche Zusammenarbeit und Entwicklung (BMZ) und in der bundeseigenen Gesellschaft für technische Zusammenarbeit (GTZ) vor, das philippinische Militär bei der Aufstandsbekämpfung zu unterstützen.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Neue Phase in indonesisch-osttimoresischer NRO-Zusammenarbeit
Creators: name: Schlicher, Monika
Publisher: name: südostasien informationen
Year: 2019

description: Zum 20. Jahrestag der Völker- und menschenrechtswidrigen Besetzung Osttimors durch Indonesien haben 40 indonesische Aktivisten der Demokratischen Volksallianz (Persatuan Rakyat Demokratik - PHD) zusammen mit 60 Osttimoresen die russische und holländische Botschaft in Jakarta besetzt. Die Aktivisten forderten den sofortigen Rückzug des indonesischen Militärs von Osttimor, die Freilassung aller politischen Gefangenen und das Recht auf Selbstbestimmung mittels eines Referendums.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Building embedded languages and expert system shells in Prolog
Creators: name: Yalcinalp, L. Umit
name: Sterling, Leon S.
Publisher: name: Swinburne
Year: 2024

description: Building embedded languages in Prolog is considered, with special attention given to expert system shells. The paradigm of metaprogramming, of which building embedded languages is an example, is discussed. Interpreters for embedded languages are reviewed with emphasis on metainterpreters. Two applications, explanation and uncertainty reasoning, are presented, and the techniques that were used in their construction are discussed.
Additional file 9 of Intolerance of uncertainty and repetitive negative thinking: transdiagnostic moderators of perfectionism in eating disorders
Creators: name: Hyde-Smith, Craig
name: Carey, Holly
name: Steward, Trevor
Publisher: name: figshare
Year: 2024
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Supplementary Material 9
Interview mit John Otto Ondowame
Creators: name: Schreiner, Klaus H.
name: Redaktion, Die
Publisher: name: südostasien informationen
Year: 2019

description: Im folgenden drucken wir Auszüge aus einem Interview, das der Sprecher der OPM (Operasi Papua Merdeka) in Australien, John Otto Ondowame der indonesischen Zeitschrift Forum Keadilan (12.2.1996) gab. Bevor Ondowame der OPM beitrat und ins australische Exil ging, war er Sekretär der GOLKAR für den Landkreis Jayapura.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Self-collection based HPV testing for cervical cancer screening among women living with HIV in Uganda: a descriptive analysis of knowledge, intentions to screen and factors associated with HPV positivity
Creators: name: Mitchell, Sheona M.
name: Pedersen, Heather N.
name: Eng Stime, Evelyn
name: Sekikubo, Musa
name: Moses, Erin
name: Mwesigwa, David
name: Biryabarema, Christine
name: Christilaw, Jan
name: Byamugisha, Josaphat K.
name: Money, Deborah M.
name: Ogilvie, Gina
Publisher: name: BioMed Central
Year: 2018

description: Background: Women living with HIV (WHIV) are disproportionately impacted by cervical dysplasia and cancer. The burden is greatest in low-income countries where limited or no access to screening exists. The goal of this study was to describe knowledge and intentions of WHIV towards HPV self-collection for cervical cancer screening, and to report on factors related to HPV positivity among women who participated in testing. Methods: A validated survey was administered to 87 HIV positive women attending the Kisenyi Health Unit aged 30–69 years old, and data was abstracted from chart review. At a later date, self-collection based HPV testing was offered to all women. Specimens were tested for high risk HPV genotypes, and women were contacted with results and referred for care. Descriptive statistics, Chi Square and Fischer-exact statistical tests were performed. Results: The vast majority of WHIV (98.9%) women did not think it necessary to be screened for cervical cancer and the majority of women had never heard of HPV (96.4%). However, almost all WHIV found self-collection for cervical cancer screening to be acceptable. Of the 87 WHIV offered self-collection, 40 women agreed to provide a sample at the HIV clinic. Among women tested, 45% were oncogenic HPV positive, where HPV 16 or 18 positivity was 15% overall. Conclusions: In this group of WHIV engaged in HIV care, there was a high prevalence of oncogenic HPV, a large proportion of which were HPV genotypes 16 or 18, in addition to low knowledge of HPV and cervical cancer screening. Improved education and cervical cancer screening for WHIV are sorely needed; self-collection based screening has the potential to be integrated with routine HIV care in this setting.
Geiselnahme in Westpapua
Creators: name: Liong, Liem Soei
name: Franke, Peter
Publisher: name: südostasien informationen
Year: 2019

description: Die Geiselnahme erfolgte in einem kleinen Dorf namens Mapenduma im Tiom Bezirk, etwa 125 km östlich von Tembagapura, dem Zentrum des Freeport/RTZ Kupfer- und Goldbergbaus, dessen Aktivitäten bereits seit Jahren in der Region umstritten sind. Das Dorf liegt im zentralen Hochland von Westpapua oder Irian Jaya, wie es die Indonesier nennen.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Characterization of methyl-accepting chemotaxis proteins (MCPs) for amino acids in plant-growth-promoting rhizobacterium Pseudomonas protegens CHA0 and enhancement of amino acid chemotaxis by MCP genes overexpression
Creators: name: Hida, Akiko
name: Oku, Shota
name: Miura, Manami
name: Matsuda, Hiroki
name: Tajima, Takahisa
name: Kato, Junichi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Pseudomonas protegens CHA0, known as plant-growth-promoting rhizobacterium, showed positive chemotactic responses toward proteinaceous L-amino acids. Genomic analysis revealed that P. protegens CHA0 possesses four putative chemoreceptors for amino acids (designated CtaA, CtaB, CtaC, and CtaD, respectively). Pseudomonas aeruginosa PCT2, a mutant defective in chemotaxis to amino acids, harboring a plasmid containing each of ctaA, ctaB, ctaC, and ctaD showed chemotactic responses to 20, 4, 4, and 11 types of amino acids, respectively. To enhance chemotaxis toward amino acids, we introduced the plasmids containing ctaA, ctaB, ctaC, or ctaD into P. protegens CHA0. By overexpression of the genes, we succeeded in enhancing chemotaxis toward more than half of the tested ligands. However, unexpectedly, the P. protegens CHA0 transformants showed unchanged or decreased responses to some amino acids when compared to wild-type CHA0. We speculate that alternation of expression of a chemoreceptor may affect the abundance of other chemoreceptors. cDNA: complementary DNA; LBD: ligand-binding domain; MCP: methyl-accepting chemotaxis protein; PDC: PhoQ/DcuS/CitA; PGPR: plant-growth-promoting rhizobacteria; qRT-PCR: quantitative reverse transcription PCR Four chemotaxis sensors for amino acids in PGPR Pseudomonas protegens CHA0. Amino acid chemotaxis can be enhanced by overexpression of the genes.
Singapur: Bereit fürs Internet?
Creators: name: Sim, Stephanie
name: Seeberger, Fritz
Publisher: name: südostasien informationen
Year: 2019

description: Was die Infrastruktur betrifft, sind wir sicherlich bereit. Sobald Computer und Gebühren billiger und die Menschen es vorziehen werden, ihre Arbeit von zu Hause aus zu erledigen statt mit den Staus in den Hauptverkehrszeiten zu kämpfen, wird Internet zum Leben gehören wie Fernsehen und Telefon. Was also Machbarkeit und Nützlichkeit betrifft: ja, wir sind wohl bereit. Aber kann unsere nationale Mentalität es verkraften?
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Additional file 7 of Intolerance of uncertainty and repetitive negative thinking: transdiagnostic moderators of perfectionism in eating disorders
Creators: name: Hyde-Smith, Craig
name: Carey, Holly
name: Steward, Trevor
Publisher: name: figshare
Year: 2024
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Supplementary Material 7
Mao in Mufti: newly identified works by Mao Zedong
Creators: name: Fitzgerald, John
Publisher: name: Swinburne
Year: 2024

description: Mao Zedong was a prominent Guomindang (GMD) official in Guangdong for about a year between September 1925 and mid-1926, but little has been revealed about his activities during this period because his association with Chiang Kai-shek has remained a source of some embarrassment to historians on both sides of the Taiwan Straits. As the relevant files in the archives of both the GMD and the Communist Party of China (CPC) are closed to researchers, progress in mapping Mao's early years has inevitably taken the form of discoveries of his speeches and writings in places readily accessible, but hitherto overlooked. It is well known that during his stay in Guangdong Mao edited the GMD magazine Zhengzhi zhoubao (Political Weekly), from which a number of articles have been culled for inclusion in compendia of his collected works. I shall argue that Mao's most important contributions to this magazine have, however, been overlooked to date through failure to recognise that five additional articles published in this magazine under the name Ziren were also written by Mao Zedong.
Inhibitors and fluorescent probes for protein kinase PKAcβ and its S54L mutant, identified in a patient with cortisol producing adenoma
Creators: name: Nonga, Olivier Etebe
name: Enkvist, Erki
name: Herberg, Friedrich W.
name: Uri, Asko
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Recently, a mutation was discovered in the gene PRKACB encoding the catalytic subunit β of PKA (PKAcβ) from a patient with severe Cushing’s syndrome. This mutation, S54L, leads to a structural change in the glycine-rich loop of the protein. In the present study, an inhibitor with six-fold selectivity toward S54L-PKAcβ mutant over the wild-type enzyme was constructed. Moreover, we developed a fluorescent assay allowing to determine side by side the affinity of commercially available PKA inhibitors, newly synthesized compounds, and fluorescent probes toward PKAcβ and S54L-PKAcβ. Characterization of compounds 9 (left panel) and 10 (right panel).
A new general distance measure for quantization of LSF and its transformed coefficients
Creators: name: Vu, Hai
name: Lois, Laszlo
Publisher: name: Swinburne
Year: 2024

description: This paper presents a new general distance measure that not only can be used in a vector quantization (VQ) of line spectrum frequency (LSF) parameters but also performs well in a LSF transformed domain. The new distance is based on the spectral sensitivity of LSFs and their transformed coefficients. In addition, a fix scaling vector is used to decrease the sensitivity of spectral error at higher frequencies. Experimental results have shown that the proposed distance measure leads to as good as or better performance of VQ compared to other methods in the field of LSF coding. The use of this distance as the weighting-function of the LSF transformed parameters is also suggested.
Chitinase system of Aeromonas salmonicida, and characterization of enzymes involved in chitin degradation
Creators: name: Iuliia Pentekhina
name: Hattori, Tatsuyuki
name: Tran, Dinh Minh
name: Shima, Mizuki
name: Watanabe, Takeshi
name: Hayuki Sugimoto
name: Suzuki, Kazushi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: The genes encoding chitin-degrading enzymes in Aeromonas salmonicida SWSY-1.411 were identified and cloned in Escherichia coli. The strain contained two glycoside hydrolase (GH) families 18 chitinases: AsChiA and AsChiB, two GH19 chitinases: AsChiC and AsChiD, and an auxiliary activities family 10 protein, lytic polysaccharide monooxygenase: AsLPMO10A. These enzymes were successfully expressed in E. coli and purified. AsChiB had the highest hydrolytic activity against insoluble chitin. AsChiD had the highest activity against water-soluble chitin. The peroxygenase activity of AsLPMO10A was lower compared to SmLPMO10A from Serratia marcescens. Synergism on powdered chitin degradation was observed when AsChiA and AsLPMO10A were combined with other chitinases of this strain. More than twice the increase of the synergistic effect was observed when powdered chitin was treated by a combination of AsLPMO10A with all chitinases. GH19 chitinases suppressed the hyphal growth of Trichoderma reesei. Synergistic effects of chitinases and LPMO of A. salmonicida on the degradation of powdered chitin, and synergy between chitinases of A. salmonicida and SmChiA or SmChiB of S. marcescens, or BcChiA1 of B. circulans.
Legislating the rainbow: legal deposit, access and distribution in a digital environment
Creators: name: Whitehead, Derek
Publisher: name: Swinburne
Year: 2024

description: This paper does not deal with the mass of issues surrounding legal deposit collections-the conference covers most of these issues in great detail. I will try to answer a fairly narrow question: Is legal deposit-legislation or regulation requiring deposit of published material-relevant to the new media? And if so, in what way? I will be looking primarily at the practicability of legal deposit as a means of obtaining and preserving documentary material. What is legal deposit? How has it changed? Can we define it? Can we enforce it? Can we do it? This paper is mainly concerned with the challenges posed to legal deposit by electronic publishing-particularly network publishing, and to a lesser extent electronic publishing using an artefact for transmission. [Introduction]
Conditions for success in introducing telemedicine in diabetes foot care: a qualitative inquiry
Creators: name: Kolltveit, Beate-Christin H.
name: Gjengedal, Eva
name: Graue, Marit
name: Iversen, Marjolein M.
name: Thorne, Sally E. (Sally Elizabeth), 1951-
name: Kirkevold, Marit
Publisher: name: BioMed Central
Year: 2018

description: Background: The uptake of various telehealth technologies to deliver health care services at a distance is expanding; however more knowledge is needed to help understand vital components for success in using telehealth in different work settings. This study was part of a larger trial designed to investigate the effect of an interactive telemedicine platform. The platform consisted of a web based ulcer record linked to a mobile phone to provide care for people with diabetic foot ulcers in outpatient clinics in specialist hospital care in collaboration with primary health care. The aim of this qualitative study was to identify perceptions of health care professionals in different working settings with respect to facilitators to engagement and participation in the application of telemedicine. Methods: Ten focus groups were conducted with health care professionals and leaders in Western Norway between January 2014 and June 2015 using Interpretive Description, an applied qualitative research strategy. Results: Four key conditions for success in using telemedicine as a new technology in diabetes foot care were identified: technology and training that were user-friendly; having a telemedicine champion in the work setting; the support of committed and responsible leaders; and effective communication channels at the organizational level. Conclusions: Successful larger scale implementation of telemedicine must involve consideration of complex contextual and organizational factors associated with different work settings. This form of new care technology in diabetes foot care often involves health care professionals working across different settings with different management systems and organizational cultures. Therefore, attention to the distinct needs of each staff group seems an essential condition for effective implementation.
Auf dem Weg zu einer Zivilgesellschaft
Creators: name: Redaktion, Die
name: Pannenborg, Änne
Publisher: name: südostasien informationen
Year: 2019

description: Thun Saray, Präsident der einheimischen Menschenrechtsorganisation ADHOC, weist die Richtung auf, in der die Stärkung einer Zivilgesellschaft in Kambodscha voran getrieben werden sollte.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Beyond one, two, three: Number matters in classifier languages
Creators: name: Lam, Cherry Chit-Yu
Publisher: name: Zenodo
Year: 2020

description: Chinese has been widely recognised as a classic example of a numeral-licensing classifier language, where the presence of a classifier is obligatory for overt quantification of nouns. This paper presents new data from Mandarin and Hong Kong Cantonese (HKC) to show that the need of classifiers for quantification is not always that absolute. Systematic variation has been found with an extended range of numerals examined (numerals larger than three), and a wider coverage of nouns in terms of animacy. The findings present a consistent pattern that HKC has a stricter requirement for classifiers in enumeration as bare common nouns are not definite in HKC, and it lacks the alternative strategies found in Mandarin.
What is the relationship between type 2 diabetes mellitus status and the neuroradiological correlates of cerebral small vessel disease in adults? Protocol for a systematic review
Creators: name: Funnell, Clark
name: Doyle-Waters, Mary M
name: Yip, Samuel
name: Field, Thalia
Publisher: name: BioMed Central
Year: 2017

description: Background: Cerebral small vessel disease (CSVD) is a common cause of stroke, dementia, and functional decline. In recent years, neuroradiologic correlates of CSVD have been identified. These imaging findings, best characterized on magnetic resonance imaging (MRI), include some combination of white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and cerebral atrophy. Though some cohorts have reported that participants with type 2 diabetes mellitus (T2DM), an important risk factor for CSVD, may have a distinct neuroradiologic phenotype, this relationship is not well-characterized. Adults with diabetes mellitus have a two- to threefold higher incidence of ischemic stroke compared to controls and are an increasingly important population given global trends of increasing diabetes prevalence. This study aims to determine if adults with CSVD and T2DM have a distinct neuroradiologic phenotype. Methods: A systematic search of the literature will be conducted to find articles that report the MRI features of CSVD in a cohort of participants including those with and without type 2 diabetes mellitus (T2DM). A number of databases will be searched including MEDLINE, Embase, CINAHL, and Web of Science. Proceedings and abstracts from key conferences will also be reviewed and relevant journals hand searched for additional papers. The references from selected papers will be scanned. Screening of potential articles, data extraction, and quality appraisal will be performed in duplicate by independent reviewers. Odds ratios and 95% confidence intervals for the presence versus absence of each neuroradiologic correlate of interest from each included study will be calculated. If sufficient homogeneity exists among studies, a meta-analysis will be performed for each neuroradiologic correlate of CSVD. If heterogeneity of studies precludes data pooling, results will be presented in narrative form. Discussion: Determining whether a distinct neuroradiologic phenotype of CSVD exists in adults with T2DM will provide insight into the underlying mechanisms of CSVD and guide future research on therapeutic targets. Systematic review registration PROSPERO CRD42016046669
Laos auf der Suche nach einem praktikablen Weg
Creators: name: Miehlau, Sabine
Publisher: name: südostasien informationen
Year: 2019

description: Noch immer - zwanzig Jahre nach ihrem Sieg - versucht die Laotische Revolutionäre Volkspartei getreu ihrem Slogan "Lang lebe der Geist des 2. Dezember" zu überleben und die Laoten unter dem Dach der "nationalen Entwicklung" zu vereinen. Aber im Gegensatz zum damaligen revolutionären Elan im Kampf aller Laoten gegen einen gemeinsamen Feind, ist es heutzutage wesentlich komplizierter, die Mitglieder zu motivieren.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Reheating constraints and the $H_0$ tension in Quintessential Inflation
Creators: name: de Haro, Jaume
name: Pan, Supriya
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work, we focus on two important aspects of modern cosmology: reheating and Hubble constant tension within the framework of a unified model, namely, quintessential inflation connecting the early inflationary era and late-time cosmic acceleration. In the context of reheating, we use instant preheating and gravitational reheating, two viable reheating mechanisms when the evolution of the universe is not affected by an oscillating regime. After obtaining the reheating temperature, we analyze the number of $e$-folds and establish its relationship with the reheating temperature. This allows us to connect, for different quintessential inflation models, the reheating temperature with the spectral index of scalar perturbations, thereby enabling us to constrain its values. In the second part of this article, we explore various alternatives to address the $H_0$ tension, a discrepancy which indicates a possible revision of the $Λ$CDM model. Initially, we establish that quintessential inflation alone cannot mitigate the Hubble tension by solely deviating from the concordance model at low redshifts. The introduction of a phantom fluid, capable of increasing the Hubble rate at the present time, becomes a crucial element in alleviating the Hubble tension, resulting in a deviation from the $Λ$CDM model only at low redshifts. On a different note, by utilizing quintessential inflation as a source of early dark energy, thereby diminishing the physical size of the sound horizon close to the baryon-photon decoupling redshift, we observe a reduction in the Hubble tension. This alternative avenue, which has the same effect of a cosmological constant changing its scale close to the recombination, sheds light on the nuanced interplay between the quintessential inflation and the Hubble tension, offering a distinct perspective on addressing this cosmological challenge.
description: 13 pages including bibliography, 5 figures; Invited article from Symmetry; Abstract has been shortened, but the full abstract is kept in the journal version; published version
Rethinking principles A and B from a Free Merge perspective
Creators: name: Richards, Marc
Publisher: name: Zenodo
Year: 2020

description: This squib sketches out the beginnings of a bottom-up, minimalist rethinking of pronominal reference constraints (essentially, principles A and B of the binding theory) in terms of an approach to grammar-internal optionality originally pursued in Biberauer & Roberts 2005, Biberauer & Richards 2006. By combining a movement theory of binding (Hornstein 2001; 2013; Kayne 2002; Abe 2014) with phase theory (Chomsky 2000 et seq.), the essential difference between local binding and local obviation reduces to the choice between Internal Merge and External Merge at the phase level, each yielding a distinct interpretive outcome at the conceptual-intentional (CI) interface. Further, if the phase constitutes the maximal domain in which linguistic constraints can apply, then interpretive freedom is expected beyond the phase level. In this way, restrictions on the interpretation of pronouns turn out to be the CI equivalent of ordering restrictions at the sensorimotor interface (PF), which likewise obtain up to the phase level but not beyond (Richards 2004; 2007).
title: Immunisation against gemetes and asexual erythrocytic stages of rodent malaria parasites
Creators: name: Mendis, K
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 1980

description: It was possible to block the transmission of an infection of a rodent malaria parasite Plasmodium yoelii nigeriensis to Anopheles stephensi mosquitoes by immunising mice with a vaccine containing formalin-fixed gametes. A single dose of the gamete vaccine containing 2x106 male gametes given intravenously was effective in blocking completely the transmission of a blood induced challenge infection. The vaccine was also effective when given intramuscularly and immunity was found to last at least six months. Transmission blocking immunity was found to reside in a serum factor, probably antibody, and to be directed against extracellular gametes, acting on them in the gut of the mosquito while gametocytes in the circulation of the vertebrate host remained unaffected. A limited study involving experimental vaccination with formalin-fixed erythrocytic parasites was also undertaken. A crude erythrocytic stage vaccine protected mice against the asexual blood stages of a challenge infection and protection was found to be enhanced by killed Bordetella pertussis organisms used as an adjuvant. The gamete vaccine afforded partial protection against the disease. Immunisation with asexual parasites alone showed that this protection was due to the presence of asexual forms as contaminants and that anti-gamete immunity is stage specific. Factors affecting the infectiousness of gametocytes in a natural infection were also investigated. It was found that mice elaborate anti-gamete immunity in response to an infection which renders it non-infectious to mosquitoes after about the fifth day. In addition, gametocytes display a pattern of altered viability during the course of an infection where they lose the capacity to exflagellate. The possibility of this being either a manifestation of an intrinsic cycle of gametocyte development or immunity mediated by non-specific non-antibody factors that affect gametocytes within red cells is discussed.
Improving learning outcomes in a multicultural classroom
Creators: name: Gerstman, Julie
name: Rex, Judith
Publisher: name: Swinburne
Year: 2024

description: Today in many universities, the classroom comprises local and international students from a wide range of backgrounds. Biggs (1999), Ramsden (1988) and Entwistle (1997) have developed the concepts of 'surface' and deep' learning for the tertiary classroom. Most students use both a 'deep' approach to learning, by focussing on understanding the meaning of reading material and a 'surface' approach by repeating explanations presented (Marton and Saljo,1976: 4-11). Students are to be encouraged to move along the continuum towards deep learning. This research study identified significant differences in academic results of international and local students in all but one of a subject's assessment tasks. As a result, a change strategy was introduced to help international students by skewing the weighting on assessment items towards those on which international students had performed relatively better. The next semester results again showed significant differences on overall assessment. A second change strategy was then introduced based on examples from Biggs' framework for 'Encouraging Deep Learning' (1999). It promotes active and analytical student learning using an incremental schedule for encouraging lower performing students to progressively use deep learning techniques in an effort to improve their learning outcomes. This paper provides a rationale and analysis of both change strategies.
Additional file 1 of Breast cancer in women with previous gestational diabetes: a nationwide register-based cohort study
Creators: name: Christensen, Maria Hornstrup
name: Vinter, Christina Anne
name: Olesen, Thomas Bastholm
name: Petersen, Maria Houborg
name: Nohr, Ellen Aagaard
name: Rubin, Katrine Hass
name: Andersen, Marianne Skovsager
name: Jensen, Dorte Moeller
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Supplementary Material 1
Vietnam: Baustelle der Marktwirtschaft
Creators: name: Siebert, Rüdiger
Publisher: name: südostasien informationen
Year: 2019

description: Partei und Regierung haben dem Kapitalismus die Tore geöffnet, versuchen nun aber, mit den vertrauten Instrumenten der Steuerung von oben nach unten unerwünschte Nebeneffekte einzudämmen.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
Buchbesprechung: Mahathir Mohamad, Shintaro lshihara: The voice of Asia. Two leaders discuss the coming Century
Creators: name: Hansen, Sven
Publisher: name: südostasien informationen
Year: 2019

description: Der malaysische Premierminister Mahathir Mohamad und der japanische Politiker Shintaro Ishi-hara sind beide als scharfe Kritiker des Westens und als Vertreter "asiatischer" Werte bekannt.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen
"Asiatische Werte" - Was ist das?
Creators: name: Schreiner, Klaus H.
Publisher: name: südostasien informationen
Year: 2019

description: Wolfgang S. Heinz spitzt mit seiner Studie: Gibt es ein asiatisches Entwicklungsmodell? Zur Diskussion über "asiatische Werte", die Frage nach spezifisch asiatischen Werten, - diesmal in Anführungszeichen - auf das Problem eines eigenen asiatischen Wegs wirtschaftlicher Entwicklung und ökonomischen Wohlstands zu.
description: südostasien informationen, Bd. 12 Nr. 1 (1996): südostasien informationen