cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Geospatial Least Cost Electrification Planning - Study Case Sierra Leone
Creators: name: Dr David Caulker
name: Carpenter, Daniel
name: Korkovelos, Alex
name: Sahlberg, Andreas
Publisher: name: Zenodo
Year: 2023
Subjects: OnSSET, GEP Patform, Scenario, QGIS, ICTP 2023

description: This research work was done during the 3 weeks training on OnSSET/GEP during the ICTP 2023 Workshop. Specific country data were collected and provided by the trainers which were used to develop scenarios and perform simulations using the GEP Generator. The results obtained from the scenarios were used as input to the QGIS software for visualisation. The findings though not exhaustive, can be used to formulate policies at governmental level. For more information, you may kindly reach out to the authors.
Additional file 1 of Inferring an animal’s environment through biologging: quantifying the environmental influence on animal movement
Creators: name: Eikelboom, J. A. J.
name: H. J. De Knegt
name: M. Klaver
name: F. Van Langevelde
name: T. Van Der Wal
name: H. H. T. Prins
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1.
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions
Creators: name: Fraisse, L.
name: Ling, Y.
name: Perkowski, A.
name: Martínez-Martínez, M.S.
name: Rullas, J.
name: Boshoff, H.I.
name: Bacqué, E.
name: Aubé, J.
name: Nathan, C.
name: Barros-Aguirre, D.
name: Jungheim, L.N.
name: Lagrange, S.
name: Zimmerman, M.
name: Li, K.
name: Joerss, D.
name: McDonald, S.L.
name: Parish, T.
name: Guijarro, L.
name: Vieth, M.
name: Filoche-Rommé, B.
name: Olsen, D.B.
name: Gold, B.
name: Dartois, V.
name: Zhang, J.
name: Bonnett, S.
name: Hipskind, P.A.
name: Roberts, J.
name: Goullieux, L.
name: Cacho, M.
name: Quezada, L.L.
name: Arora, K.
name: Scarry, S.M.
name: Wood, M.
name: Bates, R.H.
name: Shinwari, W.
name: Smith, P.
name: Rodríguez-Salguero, B.
name: Anca, S.
name: Roubert, C.
name: Berthel, S.J.
name: Nguyen, Q.
name: Young, K.
name: Porras-De Francisco, E.
name: Barry, C.E.
Publisher: name: American Chemical Society
Year: 2021

description: Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death from infection before COVID-19. Here, we developed a framework for multiple pharmaceutical companies to share proprietary information and compounds with multiple laboratories in the academic and government sectors for a broad examination of the ability of β-lactams to kill Mycobacterium tuberculosis (Mtb). In the TB Drug Accelerator (TBDA), a consortium organized by the Bill & Melinda Gates Foundation, individual pharmaceutical companies collaborate with academic screening laboratories. We developed a higher order consortium within the TBDA in which four pharmaceutical companies (GlaxoSmithKline, Sanofi, MSD, and Lilly) collectively collaborated with screeners at Weill Cornell Medicine, the Infectious Disease Research Institute (IDRI), and the National Institute of Allergy and Infectious Diseases (NIAID), pharmacologists at Rutgers University, and medicinal chemists at the University of North Carolina to screen ∼8900 β-lactams, predominantly cephalosporins, and characterize active compounds. In a striking contrast to historical expectation, 18% of β-lactams screened were active against Mtb, many without a β-lactamase inhibitor. One potent cephaloporin was active in Mtb-infected mice. The steps outlined here can serve as a blueprint for multiparty, intra- and intersector collaboration in the development of anti-infective agents.
Additional file 2 of Living with tuberculosis: a qualitative study of patients’ experiences with disease and treatment
Creators: name: Addo, Juliet
name: Pearce, Dave
name: Metcalf, Marilyn
name: Lundquist, Courtney
name: Thomas, Gillian
name: Barros-Aguirre, David
name: Koh, Gavin C. K. W.
name: Strange, Mike
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. Screening questions.
Additional file 4 of Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Creators: name: Schrott, Rose
name: Modliszewski, Jennifer L.
name: Hawkey, Andrew B.
name: Grenier, Carole
name: Holloway, Zade
name: Evans, Janequia
name: Pippen, Erica
name: Corcoran, David L.
name: Levin, Edward D.
name: Murphy, Susan K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Table S1. Pyrosequencing assay designs, primers, thermocycler conditions and genomic coordinates.
Additional file 7 of Inferring an animal’s environment through biologging: quantifying the environmental influence on animal movement
Creators: name: Eikelboom, J. A. J.
name: H. J. De Knegt
name: M. Klaver
name: F. Van Langevelde
name: T. Van Der Wal
name: H. H. T. Prins
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 7.
An RNA-binding protein, hu-antigen r, in pancreatic cancer epithelial to mesenchymal transition, metastasis, and cancer stem cells
Creators: name: Aube, J.
name: Ramesh, R.
name: Xu, L.
name: Dixon, D.A.
name: Chen, P.
name: Wang, T.
name: Wu, X.
name: Polireddy, K.
name: Chen, Q.
name: Dong, R.
Publisher: name: American Association for Cancer Research Inc.
Year: 2020

description: Pancreatic cancer has poor prognosis and treatment outcomes due to its highly metastatic nature and resistance to current treatments. The RNA-binding protein (RBP) Hu-antigen R (HuR) is a central player in posttranscriptional regulation of cancer-related gene expression, and contributes to tumorigenesis, tumor growth, metastasis, and drug resistance. HuR has been suggested to regulate pancreatic cancer epithelial-to-mesenchymal transition (EMT), but the mechanism was not well understood. Here, we further elucidated the role HuR plays in pancreatic cancer cell EMT, and developed a novel inhibitor specifically interrupting HuR–RNA binding. The data showed that HuR binds to the 30-UTR of the mRNA of the transcription factor Snail, resulting in stabilization of Snail mRNA and enhanced Snail protein expression, thus promoted EMT, metastasis, and formation of stem-like cancer cells (CSC) in pancreatic cancer cells. siRNA silencing or CRISPR/Cas9 gene deletion of HuR inhibited pancreatic cancer cell EMT, migration, invasion, and inhibited CSCs. HuR knockout cells had dampened tumorigenicity in immunocompromised mice. A novel compound KH-3 interrupted HuR–RNA binding, and KH-3 inhibited pancreatic cancer cell viability, EMT, migration/invasion in vitro. KH-3 showed HuR-dependent activity and inhibited HuR-positive tumor growth and metastasis in vivo.
TAKRORIY EKIN TARIQ YETISHTIRISHDA ILDIZDAN TASHQARI OZIQLANTIRISHNING AXAMIYATI.
Creators: name: Odinayev, Sherali
Publisher: name: Zenodo
Year: 2025

description: Ekinlar strukturasining o‘zgarishi munosabati bilan dukkakli don ekinlaridan yuqori va sifatli xosil yetishtirishda intensiv texnologiyalardan biri sug‘oriladigan maydonlarda ekilgan boshoqli don ekinlarini yig‘ishtirib olingandan so‘ng, bo‘shagan maydonlarda takroriy ekin yetishtirishni ko‘paytirishdan iborat.
Additional file 4 of Inferring an animal’s environment through biologging: quantifying the environmental influence on animal movement
Creators: name: Eikelboom, J. A. J.
name: H. J. De Knegt
name: M. Klaver
name: F. Van Langevelde
name: T. Van Der Wal
name: H. H. T. Prins
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 4.
(502679) Lucy Varney
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Young Stellar Object candidates toward the Orion region selected from GALEX
Creators: name: Sanchez, Nestor
name: de Castro, Ana Ines Gomez
name: Lopez-Martinez, Fatima
name: Lopez-Santiago, Javier
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We analyze 359 ultraviolet tiles from the All Sky Imaging Survey of the space mission GALEX covering roughly 400 square degrees toward the Orion star-forming region. There is a total of 1,555,174 ultraviolet sources that were cross-matched with others catalogs (2MASS, UCAC4, SDSS, DENIS, CMC15 and WISE) to produce a list of 290,717 reliable sources with a wide range of photometric information. Using different color selection criteria we identify 111 Young Stellar Object candidates showing both ultraviolet and infrared excesses, of which 81 are new identifications. We discuss the spatial distribution, the spectral energy distributions and other physical properties of these stars. Their properties are, in general, compatible with those expected for T Tauri stars. This population of TTS candidates is widely dispersed around the Orion molecular cloud.
description: 6 pages, 4 figures, 2 tables (available online). Accepted for publication in A&A
Additional file 3 of Living with tuberculosis: a qualitative study of patients’ experiences with disease and treatment
Creators: name: Addo, Juliet
name: Pearce, Dave
name: Metcalf, Marilyn
name: Lundquist, Courtney
name: Thomas, Gillian
name: Barros-Aguirre, David
name: Koh, Gavin C. K. W.
name: Strange, Mike
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 3. Health questionnaire and interview guide.
Impat of the S&P500 index and Covid-19 daily cases on Bitcoin in the United States.
Creators: name: ALSUKARI, DANA
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 350202
subject: Finance
classificationCode: 3502
subject: Banking, finance and investment
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 38
subject: Economics

description: The role of Bitcoin in the world economy keeps growing. In this study, a quantitative time series approach is utilized to examine the relationship between Bitcoin, the most popular cryptocurrency, the S&p500 index, and COVID-19 cases in the United States. The research questions and hypotheses are designed to examine the relationships between all these variables. The secondary data was obtained from August 1, 2019, to March 31, 2020, from official websites. COVID-19 data was obtained from the New York Times website. Data for Bitcoin and the S&p500 index was obtained from the Investing.com website. The analysis started by summarizing the data in order to see the mean values, standard deviation, skewness, and kurtosis, all of which help us visualize the distribution of the data values. The Augmented Dickey-Fuller and Phillips and Perron tests were then used to determine whether the variables were stationary or not. Since the variables are not stationary at level but at difference, the vector error correction model (VECM) was employed to check the cointegration of the variables in the short and long runs. The results showed that the rank of cointegration is equal to 1, meaning that the variables have one relationship linking them. Also, Bitcoin and the S&p500 index are reversely correlated. However, Bitcoin and COVID-19 cases are positively correlated. Investors and market participants may be implicated by the findings of the study.
Off-shell hydrodynamics from holography
Creators: name: Crossley, Michael
name: Glorioso, Paolo
name: Liu, Hong
name: Wang, Yifan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We outline a program for obtaining an action principle for dissipative fluid dynamics by considering the holographic Wilsonian renormalization group applied to systems with a gravity dual. As a first step, in this paper we restrict to systems with a non-dissipative horizon. By integrating out gapped degrees of freedom in the bulk gravitational system between an asymptotic boundary and a horizon, we are led to a formulation of hydrodynamics where the dynamical variables are not standard velocity and temperature fields, but the relative embedding of the boundary and horizon hypersurfaces. At zeroth order, this action reduces to that proposed by Dubovsky et al. as an off-shell formulation of ideal fluid dynamics.
description: 34 pages, 2 figures; v2: references added, clarifications added in Sec. IV
Complete proper holomorphic embeddings of strictly pseudoconvex domains into balls
Creators: name: Drnovsek, Barbara Drinovec
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We construct a complete proper holomorphic embedding from any strictly pseudoconvex domain with $\mathcal{C}^2$-boundary in $\mathbb{C}^n$ into the unit ball of $\mathbb{C}^N$, for $N$ large enough, thereby answering a question of Alarcon and Forstneric.
Discovery of sultam-containing small-molecule disruptors of the huntingtin–calmodulin protein–protein interaction
Creators: name: Aubé, J.
name: McDonald, P.
name: Muma, N.A.
name: Klus, N.J.
name: Roy, A.
name: Kapadia, K.
name: Frankowski, K.J.
Publisher: name: Springer
Year: 2020

description: The aberrant protein–protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to contribute to Huntington’s disease progression. A high-throughput screen for small molecules capable of disrupting this interaction revealed a sultam series as potent small-molecule disruptors. Diversification of the sultam scaffold afforded a set of 24 analogs or further evaluation. Several structure–activity trends within the analog set were found, most notably a negligible effect of absolute stereochemistry and a strong beneficial correlation with electron-withdrawing aromatic substituents. The most promising analogs were profiled for off-target effects at relevant kinases and, ultimately, one candidate molecule was evaluated for neuroprotection in a neuronal cell model of Huntington’s disease.
(502571) Napier George Sturt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist
Creators: name: Akano, E.O.
name: Southall, N.
name: Keck, T.M.
name: Steiner, J.
name: Weiner, W.S.
name: Shi, L.
name: Frankowski, K.J.
name: Hu, X.
name: Gandhi, D.
name: Abramyan, A.
name: Free, R.B.
name: Sibley, D.R.
name: Moritz, A.E.
name: Aubé, J.
name: Ferrer, M.
Publisher: name: American Chemical Society
Year: 2020

description: To identify novel D3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a β-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and selectivity. The optimized compound, ML417 (20), potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs. Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders.
IMPACT OF THE S&P500 INDEX AND COVID-19 DAILY CASES ON BITCOIN IN THE UNITED STATES
Creators: name: ALSUKARI, DANA
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 350202
subject: Finance
classificationCode: 3502
subject: Banking, finance and investment
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 38
subject: Economics

description: The role of Bitcoin in the world economy keeps growing. In this study, a quantitative time series approach is utilized to examine the relationship between Bitcoin, the most popular cryptocurrency, the S&p500 index, and COVID-19 cases in the United States. The research questions and hypotheses are designed to examine the relationships between all these variables. The secondary data was obtained from August 1, 2019, to March 31, 2020, from official websites. COVID-19 data was obtained from the New York Times website. Data for Bitcoin and the S&p500 index was obtained from the Investing.com website. The analysis started by summarizing the data in order to see the mean values, standard deviation, skewness, and kurtosis, all of which help us visualize the distribution of the data values. The Augmented Dickey-Fuller and Phillips and Perron tests were then used to determine whether the variables were stationary or not. Since the variables are not stationary at level but at difference, the vector error correction model (VECM) was employed to check the cointegration of the variables in the short and long runs. The results showed that the rank of cointegration is equal to 1, meaning that the variables have one relationship linking them. Also, Bitcoin and the S&p500 index are reversely correlated. However, Bitcoin and COVID-19 cases are positively correlated. Investors and market participants may be implicated by the findings of the study.
(502678) Betty [Maslen]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502737) Edward Stone
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of DNA barcoding detects contamination and substitution in North American herbal products
Creators: name: Newmaster, Steven G
name: Grguric, Meghan
name: Shanmughanandhan, Dhivya
name: Ramalingam, Sathishkumar
name: Ragupathy, Subramanyam
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1: Table S1: Standard reference material (SRM) herbal Barcode of Life Database (BOLD) accession numbers. (PDF 123 KB)
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases
Creators: name: Smith, R.
name: Park, S.W.
name: Nguyen, Q.
name: Lopez Quezada, L.
name: Hugonnet, J.-E.
name: Schoenen, F.J.
name: Lupoli, T.J.
name: Li, K.
name: Aubé, J.
name: Edoo, Z.
name: Roberts, J.
name: Li, X.
name: Ling, Y.
name: Gold, B.
name: Nathan, C.
name: Sacchettini, J.C.
name: Arthur, M.
Publisher: name: Frontiers Media S.A.
Year: 2020

description: As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbapenems active against replicating Mtb. Here, we investigated the targets of recently described cephalosporins that are selectively active against non-replicating (NR) Mtb. NR-active cephalosporins failed to inhibit recombinant Mtb transpeptidases. Accordingly, we used alkyne analogs of NR-active cephalosporins to pull down potential targets through unbiased activity-based protein profiling and identified over 30 protein binders. None was a transpeptidase. Several of the target candidates are plausibly related to Mtb’s survival in an NR state. However, biochemical tests and studies of loss of function mutants did not identify a unique target that accounts for the bactericidal activity of these beta-lactams against NR Mtb. Instead, NR-active cephalosporins appear to kill Mtb by collective action on multiple targets. These results highlight the ability of these β-lactams to target diverse classes of proteins.
(502570) James Aston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Burstiness and aging in social temporal networks
Creators: name: Moinet, Antoine
name: Starnini, Michele
name: Pastor-Satorras, Romualdo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The presence of burstiness in temporal social networks, revealed by a power law form of the waiting time distribution of consecutive interactions, is expected to produce aging effects in the corresponding time-integrated network. Here we propose an analytically tractable model, in which interactions among the agents are ruled by a renewal process, and that is able to reproduce this aging behavior. We develop an analytic solution for the topological properties of the integrated network produced by the model, finding that the time translation invariance of the degree distribution is broken. We validate our predictions against numerical simulations, and we check for the presence of aging effects in a empirical temporal network, ruled by bursty social interactions.
Additional file 2 of DNA barcoding detects contamination and substitution in North American herbal products
Creators: name: Newmaster, Steven G
name: Grguric, Meghan
name: Shanmughanandhan, Dhivya
name: Ramalingam, Sathishkumar
name: Ragupathy, Subramanyam
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 2: Table S2: List of GenBank accession numbers. (PDF 86 KB)
(502568) William Howard Russell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502569) Agnes Stevenson Lister
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Creators: name: Wood, S.
name: Zhong, C.
name: Karanicolas, J.
name: Gao, F.P.
name: Lan, L.
name: Wu, X.
name: Ji, M.
name: Gowthaman, R.
name: Wei, L.
name: Xu, L.
name: Marquez, R.T.
name: Han, S.
name: Li, L.
name: Welch, D.R.
name: Gardashova, G.
name: Dixon, D.A.
name: Roy, S.
name: Aubé, J.
Publisher: name: Nature Research
Year: 2020

description: Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, and cytokines that support major tumor hallmarks including invasion and metastasis. Here, we report a HuR inhibitor KH-3, which potently suppresses breast cancer cell growth and invasion. Furthermore, KH-3 inhibits breast cancer experimental lung metastasis, improves mouse survival, and reduces orthotopic tumor growth. Mechanistically, we identify FOXQ1 as a direct target of HuR. KH-3 disrupts HuR–FOXQ1 mRNA interaction, leading to inhibition of breast cancer invasion. Our study suggests that inhibiting HuR is a promising therapeutic strategy for lethal metastatic breast cancer.
(502566) Francis Baring
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Creators: name: Linehan, J.L.
name: Perez-Chaparro, P.J.
name: Vujkovic-Cvijin, I.
name: Constantinides, M.G.
name: Cua, D.J.
name: Adams, E.J.
name: Belkaid, Y.
name: Bouladoux, N.
name: Krishnamurthy, S.R.
name: Weckel, A.
name: Scharschmidt, T.C.
name: Chen, Y.E.
name: Fischbach, M.A.
name: Tamoutounour, S.
name: Wong, A.C.
name: Han, S.-J.
name: Merrill, E.D.
name: Aubé, J.
name: Bhandoola, A.
name: Farhat, S.
name: Li, K.
name: Roy, S.
name: Link, V.M.
Publisher: name: American Association for the Advancement of Science
Year: 2019

description: How early-life colonization and subsequent exposure to the microbiota affect long-term tissue immunity remains poorly understood. Here, we show that the development of mucosal-associated invariant T (MAIT) cells relies on a specific temporal window, after which MAIT cell development is permanently impaired. This imprinting depends on early-life exposure to defined microbes that synthesize riboflavin-derived antigens. In adults, cutaneous MAIT cells are a dominant population of interleukin-17A (IL-17A)-producing lymphocytes, which display a distinct transcriptional signature and can subsequently respond to skin commensals in an IL-1-, IL-18-, and antigen-dependent manner. Consequently, local activation of cutaneous MAIT cells promotes wound healing. Together, our work uncovers a privileged interaction between defined members of the microbiota and MAIT cells, which sequentially controls both tissue-imprinting and subsequent responses to injury.
Additional file 1 of Assessment of the anti-virulence potential of extracts from four plants used in traditional Chinese medicine against multidrug-resistant pathogens
Creators: name: Zhonghui Pu
name: Huaqiao Tang
name: Long, Nana
name: Qiu, Min
name: Mingxiang Gao
name: Fenghui Sun
name: Dai, Min
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Table S1. ESKAPE pathogens tested and their corresponding antibiotic resistance profiles as reported by the source provider. Table S2. Negative ESI Mass spectrometry (m/z) analysis of extract CDY3; peaks with > 0.5% relative abundance is listed. Table S3. Positive ESI Mass spectrometry (m/z) analysis of extract CDY3; peaks with > 0.5% relative abundance is listed.
Theory of Kerr and Faraday rotations and linear dichroism in Topological Weyl Semimetals
Creators: name: Kargarian, Mehdi
name: Randeria, Mohit
name: Trivedi, Nandini
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We consider the electromagnetic response of a topological Weyl semimetal (TWS) with a pair of Weyl nodes in the bulk and corresponding Fermi arcs in the surface Brillouin zone. We compute the frequency-dependent complex conductivities $σ_{αβ}(ω)$ and also take into account the modification of Maxwell equations by the topological $θ$-term to obtain the Kerr and Faraday rotations in a variety of geometries. For TWS films thinner than the wavelength, the Kerr and Faraday rotations, determined by the separation between Weyl nodes, are significantly larger than in topological insulators. In thicker films, the Kerr and Faraday angles can be enhanced by choice of film thickness and substrate refractive index. We show that, for radiation incident on a surface with Fermi arcs, there is no Kerr or Faraday rotation but the electric field develops a longitudinal component inside the TWS, and there is magnetic linear dichroism. Our results have implications for probing the TWS phase in various experimental systems.
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition
Creators: name: Morris, R.
name: Ballinger, E.
name: McConnell, J.A.
name: Blanc, I.
name: Nathan, C.
name: Sacchettini, J.
name: Aubé, J.
name: Yang, G.
name: Scarry, S.M.
name: Gold, B.
name: Vaubourgeix, J.
name: Mosior, J.
name: Bacqué, E.
name: Engelhart, C.A.
name: Fraisse, L.
name: Rhee, K.
name: Ouerfelli, O.
name: McAulay, K.
name: Burns-Huang, K.
name: Sans, S.
name: Couturier, C.
name: Hartman, T.
name: Fay, A.
name: Lagrange, S.
name: Goullieux, L.
name: Schnappinger, D.
name: Ioerger, T.R.
name: Roubert, C.
Publisher: name: American Association for the Advancement of Science
Year: 2019

description: Mycobacterium tuberculosis (Mtb) is the leading infectious cause of death in humans. Synthesis of lipids critical for Mtb’s cell wall and virulence depends on phosphopantetheinyl transferase (PptT), an enzyme that transfers 4′-phosphopantetheine (Ppt) from coenzyme A (CoA) to diverse acyl carrier proteins. We identified a compound that kills Mtb by binding and partially inhibiting PptT. Killing of Mtb by the compound is potentiated by another enzyme encoded in the same operon, Ppt hydrolase (PptH), that undoes the PptT reaction. Thus, loss-of-function mutants of PptH displayed antimicrobial resistance. Our PptT-inhibitor cocrystal structure may aid further development of antimycobacterial agents against this long-sought target. The opposing reactions of PptT and PptH uncover a regulatory pathway in CoA physiology.
3D-localization microscopy and tracking of FoF1-ATP synthases in living bacteria
Creators: name: Renz, Anja
name: Renz, Marc
name: Kluetsch, Diana
name: Deckers-Hebestreit, Gabriele
name: Börsch, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biomolecules (q-bio.BM)
subject: FOS: Biological sciences

description: FoF1-ATP synthases are membrane-embedded protein machines that catalyze the synthesis of adenosine triphosphate. Using photoactivation-based localization microscopy (PALM) in TIR-illumination as well as structured illumination microscopy (SIM), we explore the spatial distribution and track single FoF1-ATP synthases in living E. coli cells under physiological conditions at different temperatures. For quantitative diffusion analysis by mean-squared-displacement measurements, the limited size of the observation area in the membrane with its significant membrane curvature has to be considered. Therefore, we applied a 'sliding observation window' approach (M. Renz et al., Proc. SPIE 8225, 2012) and obtained the one-dimensional diffusion coefficient of FoF1-ATP synthase diffusing on the long axis in living E. coli cells.
description: 13 pages, 5 figures
W-algebras from Heisenberg categories
Creators: name: Cautis, Sabin
name: Lauda, Aaron D.
name: Licata, Anthony M.
name: Sussan, Joshua
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 81R10, 20C08, 17B65, 18D10

description: The trace (or zeroth Hochschild homology) of Khovanov's Heisenberg category is identified with a quotient of the algebra W_{1+\infty}. This induces an action of W_{1+\infty} on symmetric functions.
description: 31 pages, tikz diagrams
  Investigating the economic and environmental impact on the sales of electric vehicles in the United States: A time-series approach
Creators: name: Butt, Emad
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 400806
subject: Electrical machines and drives
classificationCode: 38
subject: Economics

description: The Biden Administration intends to create a dominant electric market by 2030, as problems with global warming and increasing dependency on gasoline rise over time, requiring an alternative on the automotive industry. This study investigates the impact of gasoline prices, CO2 emissions and GDP of the U.S. on the sales of electric vehicles using time series data between the periods 2011 to 2021 on a monthly basis. To achieve this impact, we use an augmented dickey fuller test to first test the stationary of our data, from which we can then create an autoregressive distributed lags model to bound test our variables and establish co-integration, which in result leads to short-run and long-run estimations of our variables. Diagnostic tests are further implemented to test the stability and reliability of the test with critical bounds established. The results of our study indicate that significant relationships exist between these factors on the sales of electric vehicles, where a positive relationship exists between sales to gasoline prices and GDP, and a negative relationship exists between sales to CO2 emissions. These findings open room to further implications on factors such as tax benefits, electricity prices, and charging infrastructure. Based on these findings, we can view that the U.S. is on par with its promises of electrifying half of its fleet by 2030, however a lot of work is required on other minor factors to achieve a shift from conventional gasoline vehicles to electric vehicles.
Pseudomodes and the corresponding transformation of the temperature-dependent bath correlation function
Creators: name: Schönleber, David W.
name: Croy, Alexander
name: Eisfeld, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In open system approaches with non-Markovian environments, the process of inserting an individual mode (denoted as "pseudomode") into the bath or extracting it from the bath is widely employed. This procedure, however, is typically performed on basis of the spectral density (SD) and does not incorporate temperature. Here, we show how the - temperature-dependent - bath correlation function (BCF) transforms in such a process. We present analytic formulae for the transformed BCF and numerically study the differences between factorizing initial state and global thermal (correlated) initial state of mode and bath, respectively. We find that in the regime of strong coupling of the mode to both system and bath, the differences in the BCFs give rise to pronounced differences in the dynamics of the system.
description: 12 pages, 4 figures
Additional file 4 of DNA barcoding detects contamination and substitution in North American herbal products
Creators: name: Newmaster, Steven G
name: Grguric, Meghan
name: Shanmughanandhan, Dhivya
name: Ramalingam, Sathishkumar
name: Ragupathy, Subramanyam
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Authors’ original file for figure 2
Observation of Weyl nodes in TaAs
Creators: name: Lv, B. Q.
name: Xu, N.
name: Weng, H. M.
name: Ma, J. Z.
name: Richard, P.
name: Huang, X. C.
name: Zhao, L. X.
name: Chen, G. F.
name: Matt, C.
name: Bisti, F.
name: Strokov, V.
name: Mesot, J.
name: Fang, Z.
name: Dai, X.
name: Qian, T.
name: Shi, M.
name: Ding, H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In 1929, H. Weyl proposed that the massless solution of Dirac equation represents a pair of new type particles, the so-called Weyl fermions [1]. However the existence of them in particle physics remains elusive for more than eight decades. Recently, significant advances in both topological insulators and topological semimetals have provided an alternative way to realize Weyl fermions in condensed matter as an emergent phenomenon: when two non-degenerate bands in the three-dimensional momentum space cross in the vicinity of Fermi energy (called as Weyl nodes), the low energy excitation behaves exactly the same as Weyl fermions. Here, by performing soft x-ray angle-resolved photoemission spectroscopy measurements which mainly probe bulk band structure, we directly observe the long-sought-after Weyl nodes for the first time in TaAs, whose projected locations on the (001) surface match well to the Fermi arcs, providing undisputable experimental evidence of existence of Weyl fermion quasiparticles in TaAs.
description: 10 pages, 4 figures, see also related papers on TaAs arXiv:1501.00060, arXiv:1502.04684
Additional file 2 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2 : Supplemental figure 2. Total bacterial 16SrDNA in the stool. Mice (n = 5) were treated by oral vancomycin (VAN) and colistin (CST) or not. Total 16srDNA expressed in relative quantity (fold-decrease) between VAN/CST and untreated controls (reference = 1).
Dynamic van der Waals Interaction of a Moving Atom with the Walls of a Flat Slit
Creators: name: Dedkov, G. V.
name: Kyasov, A. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A general expression was obtained for the dynamic energy of the van der Waals interaction of a neutral atom with a flat slit whose walls are characterized by a frequency-dependent dielectric permittivity. The interaction of cesium atoms with the walls of metallic (Au) and dielectric (SiC) slits id analyzed numerically at speeds of 1 E04 to 10 E07 m/s. As the speed of atoms grows, the dynamic potentials near the walls become substantially smaller in magnitude than static potentials, but, in the intermediate region, the former exceed the latter by a factor of 1.5-2.0 m/s in a specific range of speeds.
description: 5 pages, 3 figures
Additional file 5 of DNA barcoding detects contamination and substitution in North American herbal products
Creators: name: Newmaster, Steven G
name: Grguric, Meghan
name: Shanmughanandhan, Dhivya
name: Ramalingam, Sathishkumar
name: Ragupathy, Subramanyam
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Authors’ original file for figure 3
Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates
Creators: name: Gonzalez, D.
name: Lamb, K.
name: Klus, N.J.
name: McLaughlin, J.E.
name: Brouwer, K.L.R.
name: Aubé, J.
name: Cox, W.
name: Minshew, L.M.
Publisher: name: Public Library of Science
Year: 2019

description: Concerns about the extent to which graduate programs adequately prepare students for the workplace have prompted numerous calls for reform. Understanding what employers look for in doctoral graduates can help schools better align graduate training with workplace needs. Twelve pharmaceutical scientists across diverse specialties and career pathways described the skills considered requisite for success in today’s science economy. Depth and breadth of knowledge, communication, collaboration, adaptability, research productivity, experiential training, and motivation and drive were among the themes identified. These results can be used to inform the development of doctoral curricula in the biomedical sciences.
The $R_{uds}$ value in the vicinity of $ψ(3770)$ state
Creators: name: Wang, Rong
name: Cao, Xu
name: Chen, Xurong
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The anomalous line shape of the $ψ(3770)$ state has resulted in some difficulty in the determination of the $R$ value for the continuum light hadron production in the resonance energy range. We parameterize the asymmetric line shape using a Fano-type formula and extract the $R_{uds}$ value to be $2.156\pm 0.022$ from the data of BESIII Collaboration in the energy region between 3.650 and 3.872 GeV. The small discrepancy between experiment and theory is removed. The cross sections of the $e^+e^- \rightarrow hadrons$ are given by subtracting the part of continuum light hadron production and are compared to the data of the $e^+e^- \rightarrow D\bar{D}$ reaction.
description: 6 pages, 2 figures