cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ischemia-induced Upregulation of Autophagy Preludes Dysfunctional Lysosomal Storage and Associated Synaptic Impairments in Neurons
Creators: name: Zhang, Xia
name: Wei, Mengping
name: Fan, Jiahui
name: Yan, Weijie
name: Zha, Xu
name: Song, Huimeng
name: Wan, Rongqi
name: Yin, Yanling
name: Wang, Wei
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Macroautophagy/autophagy is vital for neuronal homeostasis and functions. Accumulating evidence suggest that autophagy is impaired during cerebral ischemia, contributing to neuronal dysfunction and neurodegeneration. However, the outcomes after transient modification in autophagy machinery are not fully understood. This study investigated the effects of ischemic stress on autophagy and synaptic structures using a rat model of oxygen-glucose deprivation (OGD) in hippocampal neurons and a mouse model of middle cerebral artery occlusion (MCAO). Upon acute ischemia, an initial autophagy modification occurred in an upregulation manner. Following, the number of lysosomes increased, as well as lysosomal volume, indicating dysfunctional lysosomal storage. These changes were prevented by inhibiting autophagy via 3-methyladenine (3-MA) treatment or ATG7 (autophagy related 7) knockdown, or were mimicked by rapamycin (RAPA), a known activator of autophagy. This suggests that dysfunctional lysosomal storage is associated with the early burst of autophagy. Dysfunctional lysosomal storage contributed to autophagy dysfunction because the basal level of MTOR-dependent lysosomal biogenesis in the reperfusion was not sufficient to clear undegraded cargoes after transient autophagy upregulation. Further investigation revealed that impairment of synaptic ultra-structures, accompanied by dysfunctional lysosomal storage, may result from a failure in dynamic turnover of synaptic proteins. This indicates a vital role of autophagy-lysosomal machinery in the maintenance of synaptic structures. This study supports previous evidence that dysfunctional lysosomal storage may occur following the upregulation of autophagy in neurons. Appropriate autophagosome-lysosomal functioning is vital for maintenance of neuronal synaptic function and impacts more than the few known synaptic proteins.
Ab initio study of elastic and electronic properties of cubic thorium pnictides ThPn and Th3Pn4 (Pn = P, As, and Sb)
Creators: name: Shein, I. R.
name: Ivanovskii, A. L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Full-potential linearized augmented plane-wave method with the generalized gradient approximation for the exchange-correlation potential was applied for comparative study of elastic and electronic properties of six cubic thorium pnictides ThPn and Th3Pn4, where Pn = P, As, and Sb. Optimized lattice parameters, theoretical density, independent elastic constants (Cij), bulk moduli (B), shear moduli (G), Young's moduli (Y), and Poisson's ratio (ν) were obtained for the first time and analyzed in comparison with available theoretical and experimental data. The electronic band structures, total and partial densities of states for all ThPn and Th3Pn4 phases were examined systematically. Moreover, the inter-atomic bonding pictures in thorium pnictides, as well as the relative stability of ThPn versus Th3Pn4 phases were discussed.
description: 20 pages, 6 figures
Additional file 2: of Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells
Creators: name: Huang, Huaping
name: Li, Tangying
name: Chen, Mingjing
name: Liu, Feng
name: Wu, Haifeng
name: Wang, Jie
name: Chen, Jialiang
name: Li, Xi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Table S2. Top 40 differentially expressed genes between A549/MDR cells and A549/DDP cells. (DOCX 16 kb)
Pulmonary hypertension as a primary manifestation of sarcoidosis
Creators: name: Andrade, Luisa
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Thorax
subject: CT-Angiography
subject: CT-High Resolution
subject: Conventional radiography
subject: Diagnostic procedure
subject: Hypertension

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 29 years
description: Clinical History: A 29-year-old female patient presented with progressive dyspnoea on exertion (NYHA class 3) and cough. She denied chest pain, orthopnoea, or paroxysmal nocturnal dyspnoea, or any history of deep vein thrombosis or other thromboembolic disease. She also de... Final Diagnosis: Pulmonary hypertension secondary to sarcoidosis
Synthesis of Wet-Chemically Prepared Porous-Graphene Single Layers on Si/SiO2 Substrate Increasing the Photoluminescence of MoS2 in Heterostructures
Creators: name: Wang, Yiqing
name: Neumann, Christof
name: Hußmann, Marleen
name: Cao, Qing
name: Hu, Yalei
name: Garrity, Oisin
name: Kusch, Patryk
name: Turchanin, Andrey
name: Eigler, Siegfried
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: graphene
subject: graphene oxide
subject: membranes
subject: photoluminescence
subject: porous graphene
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Wet-chemical generation of pores in graphene is a challenging synthetic task. Although graphene oxide is available in large quantities and chemically diverse, extended lattice defects already present from synthesis hamper the controlled growth of pores. However, membrane, energy, or nanoelectronic applications essentially require uniform pores in applications. Here, oxo-functionalized graphene (oxoG), a type of graphene oxide with a controlled density of vacancy defects, is used as starting material. Pores in graphene are generated from potassium permanganate treated oxoG and heating from room temperature to 400 °C. With etching time, the size of pores increases and pore-diameters of, for example, 100–200 nm in majority become accessible. The experiments are conducted on the single-layer level on Si/SiO2 wafers. Flakes remain stable on the µm scale and do not fold. The process leads to rims of pores, which are functionalized by carbonyl groups in addition to hydroxyl and carboxyl groups. In addition, it is found that heterostructures with intrinsically n-doped MoS2 can be fabricated and photoluminescence (PL) measurements reveal a 10-fold increased PL. Thus, graphene with pores is a novel highly temperature-stable electron-accepting 2D material to be integrated into van der Waals heterostructures.
Local Group Dwarf Galaxies: Nature And Nurture
Creators: name: Sawala, Till
name: Scannapieco, Cecilia
name: White, Simon
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the formation and evolution of dwarf galaxies in a high resolution, hydrodynamical cosmological simulation of a Milky Way sized halo and its environment. Our simulation includes gas cooling, star formation, supernova feedback, metal enrichment and UV heating. In total, 90 satellites and more than 400 isolated dwarf galaxies are formed in the simulation, allowing a systematic study of the internal and environmental processes that determine their evolution. We find that 95% of satellite galaxies are gas-free at z=0, and identify three mechanisms for gas loss: supernova feedback, tidal stripping, and photo-evaporation due to re-ionization. Gas-rich satellite galaxies are only found with total masses above ~ 5x10^9 solar masses. In contrast, for isolated dwarf galaxies, a total mass of ~ 10^9 solar masses constitutes a sharp transition; less massive galaxies are predominantly gas-free at z=0, more massive, isolated dwarf galaxies are often able to retain their gas. In general, we find that the total mass of a dwarf galaxy is the main factor which determines its star formation, metal enrichment, and its gas content, but that stripping may explain the observed difference in gas content between field dwarf galaxies and satellites with total masses close to 10^9 solar masses. We also find that a morphological transformation via tidal stripping of infalling, luminous dwarf galaxies whose dark matter is less concentrated than their stars, cannot explain the high total mass-light ratios of the faint dwarf spheroidal galaxies.
description: 18 pages, 13 figures, submitted to MNRAS
Measurement of the Inclusive e{\pm}p Scattering Cross Section at High Inelasticity y and of the Structure Function FL
Creators: name: H1 Collaboration
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A measurement is presented of the inclusive neutral current e\pm p scattering cross section using data collected by the H1 experiment at HERA during the years 2003 to 2007 with proton beam energies Ep of 920, 575, and 460 GeV. The kinematic range of the measurement covers low absolute four-momentum transfers squared, 1.5 GeV2 < Q2 < 120 GeV2, small values of Bjorken x, 2.9 \cdot 10-5 < x < 0.01, and extends to high inelasticity up to y = 0.85. The structure function FL is measured by combining the new results with previously published H1 data at Ep = 920 GeV and Ep = 820 GeV. The new measurements are used to test several phenomenological and QCD models applicable in this low Q2 and low x kinematic domain.
description: 70 pages, 29 figures, 23 tables
Path Integral Monte Carlo calculation of momentum distribution in solid \^4\He
Creators: name: Rota, Riccardo
name: Boronat, Jordi
Publisher: name: arXiv
Year: 2010
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We perform calculations of the momentum distribution n(k) in solid \^4\He by means of path integral Monte Carlo methods. We see that, in perfect crystal, n(k) does not depend on temperature T and that is different from the classical Gaussian shape of Maxwell-Boltzmann distribution, even though these discrepancies decrease when the density of the system increases. In crystal presenting vacancies, we see that for T \ge 0.75K, n(k) presents the same behavior as in the perfect crystal, but, at lower T, it presents a peak when k\to0.
description: 8 pages, 5 figures
Charge conservation in RHIC and contributiuons to local parity violation observables
Creators: name: Schlichting, Soeren
name: Pratt, Scott
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Relativistic heavy ion collisions provide laboratory environments from which one can study the creation of a novel state of matter, the quark gluon plasma. The existence of such a state is postulated to alter the mechanism and evolution of charge production, which then becomes manifest in charge correlations. We study the separation of balancing charges at kinetic freeze-out by analyzing recent result on balancing charge correlations for Au+Au collisions at $\sqrt{s_{NN}}=200 {GeV}$. We find that balancing charges are emitted from significantly smaller regions in central collisions compared to peripheral collisions. The results indicate that charge diffusion is small and that the centrality dependence points to a change of the production mechanism. In addition we calculate the contributions from charge-balance correlations to STAR's local parity violation observable. We find that local charge conservation, when combined with elliptic flow, explains much of STAR's measurement.
description: 11 pages, 10 figures
Karrikins control seedling photomorphogenesis and anthocyanin biosynthesis through a HY5-BBX transcriptional module
Creators: name: Bursch, Katharina
name: Niemann, Ella T.
name: Nelson, David C.
name: Johansson, Henrik
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Arabidopsis thaliana
subject: BBX proteins
subject: HY5
subject: karrikin
subject: light signaling
subject: 500 Naturwissenschaften und Mathematik::580 Pflanzen (Botanik)::580 Pflanzen (Botanik)

description: The butenolide molecule, karrikin (KAR), emerging in smoke of burned plant material, enhances light responses such as germination, inhibition of hypocotyl elongation, and anthocyanin accumulation in Arabidopsis. The KAR signaling pathway consists of KARRIKIN INSENSITIVE 2 (KAI2) and MORE AXILLARY GROWTH 2 (MAX2), which, upon activation, act in an SCF E3 ubiquitin ligase complex to target the downstream signaling components SUPPRESSOR OF MAX2 1 (SMAX1) and SMAX1-LIKE 2 (SMXL2) for degradation. How degradation of SMAX1 and SMXL2 is translated into growth responses remains unknown. Although light clearly influences the activity of KAR, the molecular connection between the two pathways is still poorly understood. Here, we demonstrate that the KAR signaling pathway promotes the activity of a transcriptional module consisting of ELONGATED HYPOCOTYL 5 (HY5), B-BOX DOMAIN PROTEIN 20 (BBX20), and BBX21. The bbx20 bbx21 mutant is largely insensitive to treatment with KAR2, similar to a hy5 mutant, with regards to inhibition of hypocotyl elongation and anthocyanin accumulation. Detailed analysis of higher order mutants in combination with RNA-sequencing analysis revealed that anthocyanin accumulation downstream of SMAX1 and SMXL2 is fully dependent on the HY5-BBX module. However, the promotion of hypocotyl elongation by SMAX1 and SMXL2 is, in contrast to KAR2 treatment, only partially dependent on BBX20, BBX21, and HY5. Taken together, these results suggest that light- and KAR-dependent signaling intersect at the HY5-BBX transcriptional module.
Callosal agenesis in craniofrontonasal dysplasia
Creators: name: Lorenzoni, Giulia
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Head and neck
subject: CT
subject: Digital radiography
subject: MR
subject: Diagnostic procedure
subject: Congenital

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 8 years
description: Clinical History: An 8-year-old female patient from Pakistan, with thick, wiry hair, came to our attention for facial asymmetry, ocular hypertelorism, and mental retardation. Final Diagnosis: The diagnosis is CFND based on radiological and clinical findings
Additional file 3 of Construction of an SNP fingerprinting database and population genetic analysis of 329 cauliflower cultivars
Creators: name: Yang, Yuyao
name: Lyu, Mingjie
name: Liu, Jun
name: Wu, Jianjin
name: Wang, Qian
name: Xie, Tianyu
name: Li, Haichao
name: Chen, Rui
name: Sun, Deling
name: Yang, Yingxia
name: Yao, Xingwei
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3.
title: Von der ostdeutschen zur marktliberalen Transformation
title: Kommentar zu Matthias Bernt und Andrej Holm „Die Ostdeutschlandforschung muss das Wohnen in den Blick nehmen"
Creators: name: Keller, Carsten
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: Transformationsforschung
subject: Wohnen
subject: subjektive und objektive Faktoren
subject: Defizitperspektive
subject: Plattenbausiedlung
subject: empirische Forschung
subject: Neoliberalismus
subject: Ost-West-Wechselwirkungen
subject: 300
subject: 710
subject: Transformation
subject: Forschung
subject: Wohnen
subject: Großtafelbau
subject: Wohnsiedlung
subject: Neoliberalismus
subject: Empirische Forschung
subject: Deutschland (DDR)
subject: Wiedervereinigung

description: Gefördert durch den Publikationsfonds der Universität Kassel
Anisotropic super-spin at the end of a carbon nanotube
Creators: name: Schmidt, Manuel J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Interaction-induced magnetism at the ends of carbon nanotubes is studied theoretically, with a special focus on magnetic anisotropies. Spin-orbit coupling, generally weak in ordinary graphene, is strongly enhanced in nanotubes. In combination with Coulomb interactions, this enhanced spin-orbit coupling gives rise to a super-spin at the ends of carbon nanotubes with an XY anisotropy on the order of 10 mK. Furthermore, it is shown that this anisotropy can be enhanced by more than one order of magnitude via a partial suppression of the super-spin.
Complement activity influences glomerular inflammation and clinical severity in IgA nephropathy and C3 glomerulopathy
Creators: name: Medjeral-Thomas, Nicholas
Publisher: name: Imperial College London
Year: 2019

description: The mechanisms that link complement activation and glomerular injury are not understood. Recently, novel mechanisms of complement dysregulation mediated by factor H related protein (FHR)1 and FHR5 have been described. IgA nephropathy (IgAN) is important and poorly understood. Exciting recent evidence suggests FHR proteins and lectin complement pathways contribute to IgAN pathogenesis. C3 glomerulopathy (C3G) demonstrates the potential for alternative complement pathway dysregulation to drive glomerular injury. However, in the majority of C3G cases, precise pathogenesis is not understood. I hypothesised IgAN and C3G pathogenesis were dependent on imbalances of FHR1, FHR5 and lectin complement pathway proteins. I demonstrated circulating FHR1 levels and the ratio of FHR1 to factor H (FH) were increased in patients with IgAN compared to healthy controls and in patients with progressive compared to stable IgAN. I found IgAN patients had higher circulating FHR5 levels than healthy controls and higher circulating FHR5 levels associated with histology markers of IgAN severity. Glomerular FHR5 deposition associated with both clinical and histologic markers of IgAN severity and immunohistolgical markers of complement activation. Glomerular FHR5 deposition also associated with clinical and histology markers of C3G severity and co-localised with glomerular complement (C)3 deposits in C3G. Glomerular FHR5 deposition co-localised with markers of both ongoing (C3b/iC3b/C3c) and previous (C3dg) alternative complement activation in C3G and IgAN. I detected FHR5 in Immunoglobulin (Ig)A containing immune complexes. With regards to the lectin complement pathway, I found IgAN patients had higher circulating levels of M-ficolin, L-ficolin, mannan binding lectin (MBL) associated serine protease (MASP)-1 and MBL associated protein (MAp)19 than healthy controls, and lower circulating levels of MASP-3 than healthy controls. Lower circulating MASP-3 levels also associated with markers of IgAN severity. My research addresses fundamental gaps in our understanding of glomerular complement activation and IgAN pathogenesis. The results are limited by a number of important confounding factors that need to be addressed. However, they justify researching the mechanisms by which FHR5 contributes to complement activation and disease severity in IgAN and C3G and could contribute to novel and exciting diagnostic tools and therapeutic targets for IgAN, C3G and other complement dependent glomerulopathies.
Additional file 4 of Construction of an SNP fingerprinting database and population genetic analysis of 329 cauliflower cultivars
Creators: name: Yang, Yuyao
name: Lyu, Mingjie
name: Liu, Jun
name: Wu, Jianjin
name: Wang, Qian
name: Xie, Tianyu
name: Li, Haichao
name: Chen, Rui
name: Sun, Deling
name: Yang, Yingxia
name: Yao, Xingwei
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4.
Miliary pulmonary metastases from mesothelioma (miliary mesothelioma)
Creators: name: Weerakkody, Yuranga
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Thorax
subject: CT
subject: Digital radiography
subject: Education
subject: Pathology

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 60 years
description: Clinical History: A 60-year-old patient on palliative chemotherapy for known pleural mesothelioma presented with a 3-week history of progressive shortness of breath and generalized deterioration. There were no signs of any concurrent second malignancy or any infection. Final Diagnosis: Miliary metastases from mesothelioma
The effects of dipeptidyl peptidase-4(DPP-4) inhibitorson the progression of diabetic nephropathy
Creators: name: Yap, Hsiu Lye
Publisher: name: Imperial College London
Year: 2020

description: I studied the effects of the DPP-4 inhibitor Linagliptin on hypoglycaemic incidence, overall glycaemic control and glycaemic variability, when compared to the sulfonylurea Gliclazide (in the randomised controlled GLOOCOSE study), and when compared to other anti-diabetic treatment regimens that do not include DPP-4 inhibitors (in the observational LINDA-CKD study). I also studied the effects of Linagliptin on the levels of inflammatory and fibrotic biomarkers associated with the progression of diabetic nephropathy. These studies were undertaken using CGM in participants with type 2 diabetes and moderate to severe CKD, or on haemodialysis. Linagliptin did not make any significant difference to hypoglycaemic incidence or glycaemic variability. In the GLOOCOSE study, randomisation to Linagliptin was significantly associated with worsening glycaemic control (higher fasting CBGs; p=0.001, higher mean CGM glucose; p=0.023, higher estimated CGM HbA1c; p=0.016) and significantly increased urine MCP- 1/creatinine ratio (p=0.002). Participants on Linagliptin in the LINDA-CKD study did not have significantly different serum or urinary MCP-1 or TGF-β1 levels compared to those not on Linagliptin. Therefore, there was insufficient evidence that Linagliptin modifies the progression of diabetic nephropathy separately from its glucose lowering actions. LINDA-CKD CKD participants had significantly more hypoglycaemic episodes than haemodialysis participants (p=0.025), however, this was in the context of haemodialysis participants spending significantly less time in normoglycaemia (47.0% vs. 65.5%; p<0.001) and more time in hyperglycaemic ranges (51.8% vs. 32.3%; p<0.001 for time above 10.0 mmol/L, 22.0% vs. 9.4%; p=0.001 for time above 13.9 mmol/L). Serum HbA1c in haemodialysis participants did not reflect their poorer glycaemic control (59 mmol/mol vs. 58 mmol/mol; p=0.649), but estimated CGM HbA1c (69 mmol/mol vs. 56 mmol/mol; p<0.001) and mean CGM glucose did (10.8 mmol/L vs. 9.0 mmol/L; p<0.001). The LINDA-CKD study results support the use of CGM in the haemodialysis population to accurately capture dynamic glucose changes and evaluate diabetes control.
title: Eugen Fraenkel: der bedeutendste Pathologe Hamburgs
Creators: name: Kuntz, Benjamin
Publisher: name: Institut für die Geschichte der deutschen Juden
Year: 2020
Subjects: subject: Wissenschaft
subject: Kunst und Kultur

description: Das Portrait zeigt den Hamburger Mediziner Eugen Fraenkel. Sein Gesichtsausdruck auf dem Bild ist ernst, die Stirn weist tiefe Falten auf, der Schnurrbart ist akkurat und die Augen schauen unter einem Zwicker hervor. Er trägt einen vornehmen Cut (schwarzes Jacket, beige Weste) mit dunklem Schlips und weißem Hemd mit Stehkragen. Gemalt hat das Bild die Hamburger Künstlerin Gretchen Wohlwill im Jahr 1928 – drei Jahre nach dem Tod Fraenkels. Als Vorlage diente eine Fotografie des Verstorbenen. Das auf Leinwand gemalte Ölportrait hat das Format 65 x 75 cm und wurde in der rechten unteren Ecke von der Künstlerin signiert. Die Medizinische Fakultät der Universität Hamburg hatte das fertige Bild 1928 erworben und in einem ihrer Gebäude aufgehängt. Wie ein erhalten gebliebener Aufkleber auf der Rückseite des Rahmens belegt, wurde das Bild später von seinem Platz entfernt und nach dem bisherigen Stand der Forschung am 12.10.1939 in einer Sammelstelle für entartete Kunst abgegeben („Eingeliefert vom Universitätskrankenhaus Eppendorf“). Heute hängt das Bild im Medizinhistorischen Museum Hamburg, das in dem einst von Stadtbaudirektor Fritz Schumacher für Fraenkel geplanten, ehemaligen Pathologiegebäude untergebracht ist.
Additional file 3: of Characterization of Dehydrin protein, CdDHN4-L and CdDHN4-S, and their differential protective roles against abiotic stress in vitro
Creators: name: Lv, Aimin
name: Su, Liantai
name: Liu, Xingchen
name: Xing, Qiang
name: Huang, Bingru
name: An, Yuan
name: Zhou, Peng
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Molecular Biology
Biological Sciences not elsewhere classified
Developmental Biology

description: Analysis of protein extracts from IPTG induced E.coli Rosetta (DE3) expressing the recombinant CdDHN4-L and CdDHN4-S. (DOCX 514 kb)
An 18-week-old fetus with spinal abnormality
Creators: name: Llorens, Roberto
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Foetal imaging
subject: Obstetric imaging
subject: Paediatric
subject: Conventional radiography
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Intrauterine diagnosis
subject: Fetus
subject: Neoplasia

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 2 days
description: Clinical History: A primigravida underwent routine prenatal sonography at 18 weeks gestation. A fluid filled spinal mass was identified so she was referred to a tertiary care facility for further evaluation and management. A full-term female infant with a protruding sacral... Final Diagnosis: Sacrococcygeal teratoma type II
Speaking for sockeye, speaking for themselves : First Nations engagement in the Cohen Commission (2009 - 2012)
Creators: name: Clarkson, Molly
Publisher: name: University of British Columbia
Year: 2016

description: This thesis examines First Nations’ perspectives on sockeye conservation through the 2009-2012 Commission to Inquire into the Decline of the Sockeye Salmon in the Fraser River, struck in response to low and falling sockeye returns. Specifically, this project asks: what can the experiences of First Nations participants at the Cohen Commission tell us about creating more space for the consideration of Indigenous peoples' knowledges and perspectives about conservation in natural resource planning and management processes? Interviews with First Nations leaders and technical and legal staff, as well as a review of Commission documents and transcripts, suggest that integration, holism, and place form some of the key characteristics of First Nations peoples’ understandings of sockeye conservation. However, those interviewed for this study identified a significant number of structural and procedural challenges and constraints to their ability to have their approach to sockeye conservation understood and incorporated into the findings and final recommendations of the Cohen Commission of Inquiry. In addition, the federal government’s failure to act (before 2016 at least) on the recommendations was perceived as a significant barrier to sockeye salmon conservation and, in turn, to the wellbeing of First Nations cultures and communities. The research findings and associated recommendations of this study align with a number of mechanisms to support transformative planning processes and outcomes previously identified in the Indigenous Planning and associated literatures. These include the development of collaborative planning structures that recognize and create space for the differing rights and responsibilities of Indigenous peoples. In addition, this study highlights the importance of developing mechanisms to ensure state accountability to respond to completed plans. The study concludes with three recommendations for reforming future natural resource planning processes that relate to First Nations’ rights, responsibilities and interests: 1) accord more space and consideration in planning to First Nations’ knowledges and worldviews; 2) engage First Nations in the development of planning mandates and procedural frameworks; 3) ensure at the onset of planning processes that policies are in place to ensure that plan outcomes are reviewed by the government(s), implementation strategies are developed and/or rationales are provided for inaction.
Short-BaseLine Electron Neutrino Disappearance
Creators: name: Giunti, Carlo
name: Laveder, Marco
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We analyzed the electron neutrino data of the Gallium radioactive source experiments and the electron antineutrino data of the reactor Bugey and Chooz experiments in terms of neutrino oscillations. We found a hint of a CPT-violating asymmetry of the effective neutrino and antineutrino mixing angles.
description: 3 pages, proceedings of NOW 2010, 4-11 September 2010, Conca Specchiulla (Otranto, Lecce, Italy)
The NH2D/NH3 ratio toward pre-protostellar cores around the UCHII region in IRAS 20293+3952
Creators: name: Busquet, G.
name: Palau, Aina
name: Estalella, R.
name: Girart, J. M.
name: Sánchez-Monge, Á.
name: Viti, S.
name: Ho, P. T. P.
name: Zhang, Q.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The deuterium fractionation, Dfrac, has been proposed as an evolutionary indicator in pre-protostellar and protostellar cores of low-mass star-forming regions. We investigate Dfrac, with high angular resolution, in the cluster environment surrounding the UCHII region IRAS 20293+3952. We performed high angular resolution observations with the IRAM Plateau de Bure Interferometer (PdBI) of the ortho-NH2D 1_{11}-1_{01} line at 85.926 GHz and compared them with previously reported VLA NH3 data. We detected strong NH2D emission toward the pre-protostellar cores identified in NH3 and dust emission, all located in the vicinity of the UCHII region IRAS 20293+3952. We found high values of Dfrac~0.1-0.8 in all the pre-protostellar cores and low values, Dfrac<0.1, associated with young stellar objects. The high values of Dfrac in pre-protostellar cores could be indicative of evolution, although outflow interactions and UV radiation could also play a role.
description: 5 pages, 3 figures. Accepted for publication in Astronomy and Astrophysics Letters
Global boundary conditions for a Dirac operator on the solid torus
Creators: name: Klimek, Slawomir
name: McBride, Matt
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study a Dirac operator subject to Atiayh-Patodi-Singer like boundary conditions on the solid torus and show that the corresponding boundary value problem is elliptic, in the sense that the Dirac operator has a compact parametrix.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Creators: name: Weerakkody, Yuranga
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Respiratory system
subject: Thorax
subject: CT
subject: CT-High Resolution
subject: Digital radiography
subject: Education
subject: Pathology

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 55 years
description: Clinical History: A 55-year-old non smoker presented with a 4-month history of mild dyspnoea and wheezing. There was no clinical or serological evidence of infection. She had been previously well and had no relevant past medical history. Final Diagnosis: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Unravelling the molecular dynamics of c-MYC’s TAD domain: a journey from simulation optimisation to drug discovery
Creators: name: Sullivan, Sandra
Publisher: name: Imperial College London
Year: 2021

description: c-MYC, part of the MYC family of transcription factors, is often deregulated in cancer, and since the early 1980’s has been identified as a prime oncogenic factor. Despite much research interest, c-MYC’s structural dynamics remain largely uncharted due to its intrinsic structural disorder. Disordered proteins are challenging to study using solely structural experimental methods, thus lately attention has turned towards the development of reliable in-silico methods to get an accurate molecular description. Molecular Dynamics simulations, commonly and successfully used to study globular proteins, can also be optimised to correctly reproduce natural protein disorder. The simulation results were assessed for convergence and conformational equilibrium, achieved by comparing the c-MYC’s Molecular Dynamics conformational landscape to similar data derived from an abundantly sampled probabilistic distribution. After the preparatory and validation work, the efforts turned to the appraisal of c-MYC’s first 88 amino acids. The revelation of its conformational states and structural dynamics opened the door for drug discovery and proof-of-concept that c-MYC should not be considered ‘undruggable’. Further exploration into the protein first 150 residues, corresponding to its transactivation domain, uncovered important structural dynamics controlled by key phosphodegron residues. Phosphorylation and mutagenesis studies demonstrated how these control mechanisms, which serve to modulate accessibility to crucial regions, are facilitated by isomerisation events within the phosphodegron. Overarchingly, this study substantiates the robustness of well-parameterised computational simulations, and machine learning methods, in uncovering the workings of otherwise difficult to study disordered proteins.
An unusual cause of occlusion of the superficial femoral artery (SFA)
Creators: name: Pozzi Mucelli, Fabio
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Bones
subject: Vascular
subject: Catheter arteriography
subject: Digital radiography
subject: Fluoroscopy
subject: Angioplasty
subject: Angioscopy
subject: Education
subject: Imaging sequences
subject: Stents
subject: Trauma

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 64 years
description: Clinical History: A 64-year-old male patient, with post-traumatic paraplegy and anxiety-depressive disorder, has been admitted to hospital for attempted suicide. During hospitalization, the patient rolled out of bed and later showed an ecchymosis in posterior area of the l... Final Diagnosis: Endovascular treatment of SFA occlusion after blunt femur fracture.
Lecture notes on stabilization of contact open books
Creators: name: van Koert, Otto
Publisher: name: arXiv
Year: 2010
Subjects: subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 53D35, 57R17

description: This note explains how to relate some contact geometric operations, such as surgery, to operations on an underlying contact open book. In particular, we shall give a simple proof of the fact that stabilizations of contact open books yield contactomorphic manifolds. Let us remark that the results in this note are all well known to experts. This note just aims to provide some references for these results.
description: 22 pages, 7 figures
Preliminary Report: Missense mutations in the APOL gene family are associated with end stage kidney disease risk previously attributed to the MYH9 gene
Creators: name: Tzur, Shay
name: Rosset, Saharon
name: Shemer, Revital
name: Yudkovsky, Guennady
name: Selig, Sara
name: Tarekegn, Ayele
name: Bekele, Endashaw
name: Bradman, Neil
name: Wasser, Walter G
name: Behar, Doron M
name: Skorecki, Karl
name: .
Publisher: name: arXiv
Year: 2010
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: MYH9 has been proposed as a major genetic risk locus for a spectrum of non-diabetic end stage kidney disease (ESKD). We use recently released sequences from the 1000 Genomes Project to identify two western African specific missense mutations (S342G and I384M) in the neighbouring APOL1 gene, and demonstrate that these are more strongly associated with ESKD than previously reported MYH9 variants. We also show that the distribution of these risk variants in African populations is consistent with the pattern of African ancestry ESKD risk previously attributed to the MYH9 gene. Additional associations were also found among other members of the APOL gene family, and we propose that ESKD risk is caused by western African variants in members of the APOL gene family, which evolved to confer protection against pathogens, such as Trypanosoma.
description: 25 pages, 6 figures
Coeliac dissection after blunt trauma
Creators: name: Kalovidouri, Anastasia Maria
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Abdomen
subject: Arteries / Aorta
subject: Spleen
subject: CT-Angiography
subject: PACS
subject: Ultrasound
subject: Arterial access
subject: Diagnostic procedure
subject: Surgery
subject: Dissection

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 37 years
description: Clinical History: A 37-year-old patient without any significant medical history presented to our emergency department with epigastric pain and heaviness two days after having received a minor impact to his left hypochondriac region. He was haemodynamically stable. The usua... Final Diagnosis: Isolated coeliac dissection after blunt trauma
Development of power-scaled tunable alexandrite lasers
Creators: name: Tawy, Goronwy
Publisher: name: Imperial College London
Year: 2021

description: Alexandrite is a highly attractive laser source in the near-infrared owing to its broad wavelength coverage of around 700-820nm and strong thermo-mechanical properties. This makes it a suitable laser source for a number of applications including remote sensing, biophotonics and quantum technologies. Over the last ten years there has been considerable progress in the development of red-diode-pumped Alexandrite lasers, however there remained to be a demonstration of multi-watt Alexandrite lasers with wavelength tuning in fundamental TEM00 transverse and single-longitudinal-mode (SLM) operation. The aim of this work is therefore to develop power-scaled Alexandrite lasers with wavelength tuning which will bring it closer to applications outside the laser laboratory. A novel wavelength-tunable and dual wavelength Alexandrite laser is presented with a continuous wavelength tuning range of 747-768nm using the crystal as both the gain medium and wavelength tuning element. For accurate laser cavity design a detailed study of pump-induced lensing in Alexandrite lasers is performed. This includes the development of an analytical theoretical model and direct wavefront measurement under both non-lasing and lasing conditions. New insight into pump-induced lensing in Alexandrite is gained and a combined thermal and population lens postulated. Utilising this improved understanding, a record power of 8.6W is demonstrated in diffraction-limited TEM00 mode. >1W over 730-805nm and >4W over 755-780nm narrow-linewidth wavelength tuning is achieved for the very first time from a red-diode-pumped Alexandrite laser. This power is higher than any other directly diode-pumped vibronic laser in the 700-820nm region. SLM operation is demonstrated in two compact ring laser cavities with up to 1W of output power. Power scaled ring lasers up to the 5W-level are also presented showing promising signs for >1W wavelength tunable SLM performance.
Electron sound in metals
Creators: name: Avramenko, Yu. A.
name: Bezuglyi, E. V.
name: Burma, N. G.
name: Fil', V. D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: This paper is devoted to the investigation of electron sound -- oscillations of the electron distribution function coupled with elastic deformation and propagating with the Fermi velocity. The amplitude-phase relations characterizing the behavior of the electron sound in Ga single crystals are determined experimentally. A model problem of excitation of electron sound in a compensated metal with equivalent bands is solved for a finite sample with diffusive scattering of electrons at the interfaces. It was found that the displacement amplitude of the receiving interface is two orders of magnitude larger than the elastic amplitude of the wave due to electron pressure. It was established that the changes occurring in the amplitude and phase of the electron sound waves at a superconducting transition do not depend on the path traversed by the wave, i.e. they refer only to the behavior of the transformation coefficient.
description: 11 pages, 11 figures
Diagnosis of groove pancreatitis in patient with chronic pancreatitis and recurrent abdominal pain
Creators: name: Lorenzoni, Giulia
Publisher: name: EURORAD
Year: 2013
Subjects: subject: Abdomen
subject: CAD
subject: CT
subject: Image manipulation / Reconstruction
subject: MR
subject: Abscess delineation
subject: Colonography MR
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Imaging sequences
subject: Acute
subject: Pathology

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 62 years
description: Clinical History: A 62-year-old man was urgently admitted to our hospital with severe epigastric pain and vomiting. The patient had a history of chronic pancreatitis for the past 2 years. Laboratory findings showed: Amylase 421 U/l; Lipase 82 U/l;Ca 19.9 and CEA in normal ... Final Diagnosis: Groove pancreatitis
title: Eugen Fraenkel: Hamburg’s most important pathologist
Creators: name: Kuntz, Benjamin
Publisher: name: Institute for the History of the German Jews
Year: 2020
Subjects: subject: Scholarship
subject: Arts and Culture

description: This portrait shows the Hamburg physician Eugen Fraenkel. His facial expression is serious, the forehead is marked by deep wrinkles, his moustache is accurate, and he gazes at the beholder through a pair of pince-nez. He wears a distinguished suit (black jacket, beige vest) with dark tie and white shirt and stand-up collar. The picture was painted by the Hamburg artist Gretchen Wohlwill in 1928 – three years after Fraenkel’s death. A photograph of the deceased served as a model. The oil portrait painted on canvas measures 65 x 75 cm and was signed by the artist in the lower right corner. The medical faculty of Hamburg University acquired the finished painting in 1928 and hung it in one of its buildings. As evidenced by a preserved label on the back of the frame, the painting was later removed from its place and, according to the current state of research, delivered to a collection point for “degenerate art” on October 12, 1939 (“Deposited by Eppendorf University Hospital”). Today, the painting hangs in Hamburg’s Museum for the History of Medicine, which is housed in the former pathology building once planned for Fraenkel by city building director Fritz Schumacher.
Ultraspinning instability: the missing link
Creators: name: Dias, Oscar J. C.
name: Monteiro, Ricardo
name: Santos, Jorge E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study linearized perturbations of Myers-Perry black holes in d=7, with two of the three angular momenta set to be equal, and show that instabilities always appear before extremality. Analogous results are expected for all higher odd d. We determine numerically the stationary perturbations that mark the onset of instability for the modes that preserve the isometries of the background. The onset is continuously connected between the previously studied sectors of solutions with a single angular momentum and solutions with all angular momenta equal. This shows that the near-extremality instabilities are of the same nature as the ultraspinning instability of d>5 singly-spinning solutions, for which the angular momentum is unbounded. Our results raise the question of whether there are any extremal Myers-Perry black holes which are stable in d>5.
description: 19 pages. 1 figure
Additional file 1: of Characterization of Dehydrin protein, CdDHN4-L and CdDHN4-S, and their differential protective roles against abiotic stress in vitro
Creators: name: Lv, Aimin
name: Su, Liantai
name: Liu, Xingchen
name: Xing, Qiang
name: Huang, Bingru
name: An, Yuan
name: Zhou, Peng
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: BSA, CdDHN4-L and CdDHN4-S were treated with Trypsin and proteinase K. (DOCX 152 kb)
Inertialess swimming and propulsion of slender bodies
Creators: name: Peng, Zhiwei
Publisher: name: University of British Columbia
Year: 2016

description: In this thesis, two problems relevant to the biological locomotion in inertialess environments are studied, one is the characteristics of undulatory locomotion in granular media, the other is the optimal flexibility of a driven microfilament in a viscous fluid. Undulatory locomotion is ubiquitous in nature and observed in different media, from the swimming of flagellated microorganisms in biological fluids, to the slithering of snakes on land, or the locomotion of sandfish lizards in sand. Despite the similarity in the undulating pattern, the swimming characteristics depend on the rheological properties of different media. Analysis of locomotion in granular materials is relatively less developed compared with fluids partially due to a lack of validated force models but recently a resistive force theory in granular media has been proposed and shown useful in studying the locomotion of a sand-swimming lizard. In this work, we employ the proposed model to investigate the swimming characteristics of a slender filament, of both finite and infinite length, undulating in a granular medium and compare the results with swimming in viscous fluids. In particular, we characterize the effects of drifting and pitching in terms of propulsion speed and efficiency for a finite sinusoidal swimmer. We also find that, similar to Lighthill's results using resistive force theory in viscous fluids, the sawtooth swimmer is the optimal waveform for propulsion speed at a given power consumption in granular media. Though it is understood that flexibility can improve the propulsive performance of a filament in a viscous fluid, the flexibility distribution that generates optimal propulsion remains largely unexplored. In this work, we employ the resistive force theory combined with the Euler-Bernoulli beam model to examine the optimal flexibility of a boundary driven filament in the small oscillation amplitude limit. We show that the optimality qualitatively depends on the boundary actuation. For large amplitude actuation, our numerics show that complex asymmetry in the waveforms emerge. The results complement our understanding of inertialess locomotion and provide insights into the effective design of locomotive systems in various environments.