cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structural properties and Raman spectroscopy of lipid Langmuir monolayers at the air-water interface
Creators: name: Dai, Shuxi
name: Zhang, Xingtang
name: Du, Zuliang
name: Huang, Yabin
name: Dang, Hongxin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Spectra of octadecylamine (ODA) Langmuir monolayers and egg phosphatidylcholine (PC)/ODA-mixed monolayers at the air-water interface have been acquired. The organization of the monolayers has been characterized by surface pressure-area isotherms. Application of polarized optical microscopy provides further insight in the domain structures and interactions of the film components. Surface-enhanced Raman scattering (SERS) data indicate that enhancement in Raman spectra can be obtained by strong interaction between headgroups of the surfactants and silver particles in subphase. By mixing ODA with phospholipid molecules and spreading the mixture at the air-water interface, we acquired vibrational information of phospholipid molecules with surfactant-aided SERS effect.
description: 8 pages, 9 figures
Fürsorgerische Unterbringung im Erwachsenenschutz: Eine Entscheidungs- und Handlungsgrundlage für Berufsbeiständinnen und Berufsbeistände von betroffenen Personen
Creators: name: Zollinger, Estefania
Publisher: name: Zenodo
Year: 2019

description: Die Bachelor Arbeit setzt sich mit der fürsorgerischen Unterbringung (FU) und dem Handlungsfeld von Berufsbeistandspersonen auseinander. Die FU ist Teil der behördlichen Massnahmen im schweizerischen Zivilgesetzbuch (ZGB). Die damit verbundenen Zwangsmassnahmen stellen einen schwerwiegenden Eingriff in die persönlichen Grundrechte dar. Deshalb sind von Gesetzes wegen mildere Massnahmen zu prüfen (Jürg Gassmann, 2011, S. 12). Die FU kann auch Personen betreffen, für die bereits eine Beistandschaft besteht. Gemäss Art. 390 ZGB müssen für die Errichtung einer Beistandschaft Schwächezustände vorliegen (Patrick Fassbind, 2016, S. 15). Diese oder damit verbundene Schwächezustände können auch die Gründe sein, dass es zu einer FU kommt. Die Berufsbeistandsperson erhält im Rahmen der Mandatsführung Zugang zur betroffenen Person und verfügt über fallspezifisches Wissen, welches bei einer FU allenfalls als Mittel für mildere Massnahmen zum Tragen kommen könnte. Hier gilt es für Berufsbeistandspersonen abzuschätzen, ob und in wie weit sie im Rahmen ihres gesetzlichen und/oder berufsethischen Auftrags für die betroffene Person anwaltschaftlich eintreten und sich in den interdisziplinären Austausch begeben. Die Thematik wird grundlegend aufbereitet und in Form eines Flussdiagramms als Entscheidungs- und Handlungsgrundlage für Berufsbeistandspersonen festgehalten.
description: + Code Diss LU: hslusa basa 2019 + Fussnote: Bachelorarbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit, 2019 + NL-Code: NLLUHSA201903
Jacob Christian Heusser an Familie
Creators: name: Heusser, Jacob Christian
Publisher: name: [s.n.]
Year: 1861

description: Textincipit: "Liebe Mama, Tante Regeli u. Schwestern! / Wenn ich im letzten Briefe versprochen habe, nach meiner Rückkehr vom / Camp ausführlicher zu schreiben, so kann ich doch heute mein Wort nur theilweise hal- / ten, da ich nur für kurze Zeit nach Buenos Air. gekommen bin. [...]"
Black hole triggered star formation in the dwarf galaxy Henize 2-10
Creators: name: Schutte, Zachary
name: Reines, Amy
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Black hole driven outflows have been observed in some dwarf galaxies with active galactic nuclei (1), and likely play a role in heating and expelling gas (thereby suppressing star formation), as they do in larger galaxies (2). The extent to which black hole outflows can trigger star formation in dwarf galaxies is unclear, because work in this area has hitherto focused on massive galaxies and the observational evidence is scarce (3,4,5). Henize 2-10 is a dwarf starburst galaxy previously reported to have a central massive black hole (6,7,8,9), though that interpretation has been disputed since some aspects of the observational evidence are also consistent with a supernova remnant (10,11). At a distance of ~9 Mpc, it presents an opportunity to resolve the central region and determine if there is evidence for a black hole outflow impacting star formation. Here we report optical observations of Henize 2-10 with a linear resolution of a few parsecs. We find a ~150 pc long ionized filament connecting the region of the black hole with a site of recent star formation. Spectroscopy reveals a sinusoid-like position-velocity structure that is well described by a simple precessing bipolar outflow. We conclude that this black hole outflow triggered the star formation.
description: 19 pages, 12 figures, published in Nature on January 19, 2022
Evaluation of pharmacological efficacy and safety of hydroxyurea in sickle cell disease: Study of a pediatric cohort from Chhattisgarh, India
Creators: name: Lad, Harsha
name: Naskar, Shoma
name: Pasupuleti, S. K. D. B. Punyasri
name: Nahrel, Rakesh
name: Sihare, Pradeep
name: Chandak, Giriraj R.
name: Patra, Pradeep K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Sickle cell disease (SCD) is a disease of abnormal hemoglobin associated with severe clinical phenotype and recurrent complications. Hydroxyurea (HU) is one of the US-FDA approved and commonly used drug for the treatment of adult SCD patients with clinical ­severity. However, its use in the pediatric groups remains atypical. Despite a high prevalence of the disease in the state Chhattisgarh, there is a lack of evidence supporting its use in pediatric patients. This study aimed to evaluate the pharmacological and clinical efficacy and safety of HU in a large pediatric cohort with SCD from Central India. The study cohort consisted of 164 SCD (138 Hb SS and 26 Hb S beta-thalassemia) children (≤14 years of age) on HU therapy, who were monitored for toxicity, hematological and clinical efficacy at baseline (Pre-HU) and after 24 months (Post-HU). The results highlight the beneficial effects of HU at a mean dose of 18.7 ± 7.0 mg/kg/day. A significant improvement was observed, not only in physical and clinical parameters but also in hematological parameters which include fetal hemoglobin (Hb F), total hemoglobin, hematocrit, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) levels, when evaluated against the baseline. We did not observe any significant adverse effects during the treatment period. Similar results were obtained on independent analysis of Hb SS and Hb Sβ patients. These findings strengthen the beneficial effect of hydroxyurea in pediatric population also without any serious adverse effects and builds up ground for expanding its use under regular monitoring.
Playing with history : settlement narratives in performance at three history museums of the Lower Mainland
Creators: name: Clausen, Amy
Publisher: name: University of British Columbia
Year: 2014

description: This is a qualitative study of the settlement narratives that are performed at three Lower Mainland historic sites and museums. Employing costumed interpreters to animate and interpret staged historic environments and texts, museum sites are understood as performance spaces. Using this lens, combined with postmodern sensibilities of narrative and ethics, and a critical eye toward racist and colonial worldviews, I observe and analyze narratives of settlement at Fort Langley National Historic Site, Irving House Museum, and Burnaby Village Museum. With careful attention to the material signifiers of theatre, and the uses of staging environments, I also analyze how narratives at each site open or close themselves to contestation. I advance an argument that certain theatrical devices may hold narratives temporally, spatially, aesthetically captive in performative museum spaces. In resisting these captivating devices, performers and audiences alike can confront and contemplate narratives that complicate the status quo, and ultimately come closer to the expression of radical intellectual equality.
Generalized Chaplygin gas model: Cosmological consequences and statefinder diagnosis
Creators: name: Malekjani, M.
name: Khodam-Mohammadi, A.
name: Nazari-Pooya, N.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The generalized Chaplygin gas (GCG) model in spatially flat universe is investigated. The cosmological consequences led by GCG model including the evolution of EoS parameter, deceleration parameter and dimensionless Hubble parameter are calculated. We show that the GCG model behaves as a general quintessence model. The GCG model can also represent the pressureless CDM model at the early time and cosmological constant model at the late time. The dependency of transition from decelerated expansion to accelerated expansion on the parameters of model is investigated. The statefinder parameters $r$ and $s$ in this model are derived and the evolutionary trajectories in $s-r$ plane are plotted. Finally, based on current observational data, we plot the evolutionary trajectories in $s-r$ and $q-r$ planes for best fit values of the parameters of GCG model. It has been shown that although, there are similarities between GCG model and other forms of chaplygin gas in statefinder plane, but the distance of this model from the $Λ$CDM fixed point in $s-r$ diagram is shorter compare with standard chaplygin gas model.
description: 10 pages, 5 figures, accepted in Astrophys Space Sci. (2011)
Additional file 5 of Preference of individuals in the treatment strategies of acute myocardial infarction in China: a discrete choice experiment
Creators: name: Dai, Weiqian
name: Liu, Chang
name: Liu, Jiahe
name: Lin, Yaduan
name: Cheng, Yu
name: Ming, Wai-kit
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 5: Table 2. Demographics and Characteristics of Patients in this Study.
Global caregiver concerns of SARS-CoV-2 vaccination in children with cancer: a cross-sectional mixed-methods study
Creators: name: Gumy, Julia M.
name: Silverstein, Allison
name: Kaye, Erica C.
name: Caniza, Miguela A.
name: Homsi, Maysam R.
name: Pritchard-Jones, Kathy
name: Bate, Jessica M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: The objective of this study was to understand global caregiver concerns about SARS-CoV-2 vaccination for children with cancer and to provide healthcare providers with guidance to support parental decision-making. A co-designed cross-sectional mixed-methods survey was distributed to primary caregivers of children with cancer globally between April and May 2021 via several media. Caregivers were asked to rate the importance of vaccine-related questions and the median scores were ranked. Principal Component Analysis was conducted to identify underlying dimensions of caregiver concerns by World Bank income groups. Content analysis of free-text responses was conducted and triangulated with the quantitative findings. 627 caregivers from 22 countries responded to the survey with 5.3% (n = 67) responses from low-and-middle-income countries (LMIC). 184 caregivers (29%) provided free-text responses. Side effects and vaccine safety were caregivers’ primary concerns in all countries. Questions related to logistics were of concern for caregivers in LMIC. A small minority of caregivers (n = 17) did not consider the survey questions important; free-text analysis identified these parents as vaccine hesitant, some of them quoting safety and side effects as main reasons for hesitancy. Healthcare providers and other community organizations globally need to provide tailored information about vaccine safety and effectiveness in pediatric oncology settings. Importantly, continued efforts are imperative to reduce global inequities in logistical access to vaccines, particularly in LMIC.
Additional file 11 of Language as a barrier to colorectal cancer screening in flanders: an ecological study
Creators: name: Van den bergh, Simon
name: Casas, Lidia
name: Ertaylan, Gökhan
name: Van Hal, Guido
name: Bessems, Jos
Publisher: name: figshare
Year: 2025
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 11
การหาประสิทธิภาพชุดกิจกรรมการเรียนรู้แบบร่วมมือโดยใช้เทคนิค STADเรื่อง ชนิดของคำ เพื่อส่งเสริมผลสัมฤทธิ์ทางการเรียนวิชาภาษาไทยสำหรับนักเรียนชั้นประถมศึกษาปีที่ 6
Creators: name: ปนัดดา เดชแฟง
Publisher: name: ึคณะครุศาสตร์ มหาวิทยาลัยราชภัฏพิบูลสงคราม
Year: 2021
Subjects: Activity Package
Learning Activity set using STAD techniques
Word types

description: วารสารครุพิบูล, 8, 1, 14-22
Spin valve effect in two-dimensional VSe$_2$ system
Creators: name: Jafari, M. A.
name: Wawrzyniak-Adamczewska, M.
name: Stagraczyński, S.
name: Dyrdal, A.
name: Barnaś, J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Vanadium based dichalcogenides, VSe$_2$, are two-dimensional materials in which magnetic Vanadium atoms are arranged in a hexagonal lattice and are coupled ferromagnetically within the plane. However, adjacent atomic planes are coupled antiferromagnetically. This provides new and interesting opportunities for application in spintronics and data storage and processing technologies. A spin valve magnetoresistance may be achieved when magnetic moments of both atomic planes are driven to parallel alignment by an external magnetic field. The resistance change associated with the transition from antiparallel to the parallel configuration is qualitatively similar to that observed in artificially layered metallic magnetic structures. Detailed electronic structure of VSe$_2$ was obtained from DFT calculations. Then, the ballistic spin-valve magnetoresistance was determined within the Landauer formalism. In addition, we also analyze thermal and thermoelectric properties. Both phases of VSe$_2$, denoted as H and T, are considered.
description: This paper is including 8 pages as well as 4 figures
In silico Evaluation of Savirin Derivatives As Inhibitors of the agr Quorum Sensing System of Staphylococcus aureus
Creators: name: Basak, Hriday Kumar
name: Paswan, Uttam
name: Ghosh, Joydeep
name: Saha, Soumen
name: Chatterjee, Abhik
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Bacterial resistance to current antibacterial agents is a global challenge. The problem of bacterial resistance can be addressed by targeting the bacterial virulence gene expression, particularly quorum sensing (QS) mechanism which is cell to cell communication. Expression of various virulence genes is regulated by the agr QS system of S. aureus, which can be attenuated by inhibiting AgrA-DNA interactions. In this paper molecular docking study was done for savirin and its thirty derivatives with AgrA protein (PDB ID: 4G4K) of S. aureus in order to find out potential inhibitors of AgrA DNA binding activity. Out of the thirty derivatives of savirin, compounds 4, 7, 17, 20, 26 and 30 showed excellent binding scores (less than -10 kcal/mol). Molecular dynamics simulations of the above protein-ligand complexes along with savirin suggested that the complexes of compounds 4, 7, 17, 20, 26 and 30 are stable. MM/PB(GB)SA binding energy calculation showed that compounds 20 and 30 have higher binding affinity among the other compounds. Density functional theory based electronic properties of the compounds were also calculated. Compounds 20 and 30 possess very good drug likeness properties and hence, can be used as potential inhibitors against agr QS system of S. aureus.
Synthesis, Thermoluminescence and Photoluminescence Study of Gd3+ Doped La2Zr2O7 Phosphor
Creators: name: Parganiha, Mamta
name: Dubey, Vikas
name: Shrivastava, Ravi
name: Kaur, Jagjeet
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: Thermoluminescence (TL) and photoluminescence (PL) properties of the Gd3+ doped lanthanum zirconium phosphor (La2Zr2O7:Gd3+) are reported in this work. Gd3+ doped La2Zr2O7 (LZO) phosphor has been prepared via a high temperature solid state reaction method and it was prepared by using H3BO3 (as flux) and the preliminary materials were La2O3, ZrO2 and Gd2O3. The results of the XRD study shows that La2Zr2O7:Gd3+ phosphor has the cubic structure with 51.68 nm average crystallite size. The TL studies were carried out for the prepared phosphors using UV radiation (UV 254 nm), and a single glow peak was found in this study. Herein to extract the information about the positions of the TL emission at this work the peak shape methods are usage and the maximum peak exhibit the general order kinetics. In TL study the effect of UV exposure was investigated, it was found that it showed linearity with dose, which is helpful in TL dosimeters. The PL emission peaks of Gd -doped LZO phosphors were found to be in the region 450-650 nm, which was due to the 4f-4f transitions of Gd3+. More intense peaks at 468, 539, 589 and 627 nm were found at room temperature under excitation at 276 nm. Here the afterglow and photoluminescence behaviour of the Gd doped LZO phosphor is also reported.
Jacob Christian Heusser an Familie
Creators: name: Heusser, Jacob Christian
Publisher: name: [s.n.]
Year: 1860

description: Textincipit: "Liebe Mama, Tte Regeli u. Schwestern! / Eure Briefe vom Jakobs-Tag liegen vor mir; ich habe zwar wenig / Zeit zum Antworten, will ab. noch schnell d. Feder ergreifen, um / so mehr, als ich mit dem nächst folgenden Schiff, das Euch Briefe für den Monat December, Weihnacht u. Neuhahr bringen sollte, wahr- / scheinlich nicht werde schreiben können, [...]"
Additional file 1 of Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus
Creators: name: Li, Tian
name: Providencia, Rui
name: Mu, Nan
name: Yin, Yue
name: Chen, Mai
name: Wang, Yishi
name: Liu, Manling
name: Yu, Lu
name: Gu, Chunhu
name: Ma, Heng
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Additional file 1. Additional figures and tables.
Evaluation of pharmacological efficacy and safety of hydroxyurea in sickle cell disease: Study of a pediatric cohort from Chhattisgarh, India
Creators: name: Lad, Harsha
name: Naskar, Shoma
name: Pasupuleti, S. K. D. B. Punyasri
name: Nahrel, Rakesh
name: Sihare, Pradeep
name: Chandak, Giriraj R.
name: Patra, Pradeep K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Sickle cell disease (SCD) is a disease of abnormal hemoglobin associated with severe clinical phenotype and recurrent complications. Hydroxyurea (HU) is one of the US-FDA approved and commonly used drug for the treatment of adult SCD patients with clinical ­severity. However, its use in the pediatric groups remains atypical. Despite a high prevalence of the disease in the state Chhattisgarh, there is a lack of evidence supporting its use in pediatric patients. This study aimed to evaluate the pharmacological and clinical efficacy and safety of HU in a large pediatric cohort with SCD from Central India. The study cohort consisted of 164 SCD (138 Hb SS and 26 Hb S beta-thalassemia) children (≤14 years of age) on HU therapy, who were monitored for toxicity, hematological and clinical efficacy at baseline (Pre-HU) and after 24 months (Post-HU). The results highlight the beneficial effects of HU at a mean dose of 18.7 ± 7.0 mg/kg/day. A significant improvement was observed, not only in physical and clinical parameters but also in hematological parameters which include fetal hemoglobin (Hb F), total hemoglobin, hematocrit, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) levels, when evaluated against the baseline. We did not observe any significant adverse effects during the treatment period. Similar results were obtained on independent analysis of Hb SS and Hb Sβ patients. These findings strengthen the beneficial effect of hydroxyurea in pediatric population also without any serious adverse effects and builds up ground for expanding its use under regular monitoring.
Additional file 3 of Preference of individuals in the treatment strategies of acute myocardial infarction in China: a discrete choice experiment
Creators: name: Dai, Weiqian
name: Liu, Chang
name: Liu, Jiahe
name: Lin, Yaduan
name: Cheng, Yu
name: Ming, Wai-kit
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3. The website of the questionnaire: http://t.cn/ROlvKtL .
Predigt, 1846 in Reigoldswil gehalten
Creators: name: Linder, Johann Rudolf
Publisher: name: [s.n.]
Year: 1846

description: 15 mit Kreuzstich zusammengeheftete Einzelblätter, eingeschlagen in aus einem grösseren Heft gerissenes Blatt, auf welchem mit Bleistift Spalten sowie mit Tinte die Seitenzahlen 247 und 248 eingetragen sind. Es ist ausserdem mit "Predigt gehalten in Reigoldswil. 1846." beschriftet. Die Predigt ist in drei Teile gegliedert (untitulierte Einleitung, 1. und 2.); Seite 3a ist leer.
description: Johann Rudolf Linder (1812-1879)
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Dez. 2009 Titel, Jahr und Signatur nach: Steinmann, unpublizierte Beschreibung
description: Verzeichnung=Description=Inventaire Oktober 2024 Minimalaufnahme nach Autopsie und Steinmann
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
description: Erschliessungsniveau Minimalniveau
Additional file 1 of Breast cancer assessment under neoadjuvant systemic therapy using thoracic photon-counting detector computed tomography in prone position: a pilot study
Creators: name: Neubauer, Claudia
name: Nattenmüller, Johanna
name: Bamberg, Fabian
name: Windfuhr-Blum, Marisa
name: Neubauer, Jakob
Publisher: name: figshare
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Table 1. Comparison of tumor size and stage in MRI and PCCT before and in histopathology and PCCT after neoadjuvant systemic therapy. Measurements in PCCT include unenhancing (PCCT unenhanced) and enhancing tumor size (PCCT enhanced) in the monoenergetic 65 keV reconstructions and enhancing tumor size in the iodine map (PCCT iodine map) for reader 1/2/3, respectively. For case 1 and 9 the repeated measurements of total tumor size in PCCT after neoadjuvant systemic therapy performed by reader 1 and 2 are shown in brackets. Supplementary Table 2. Number of suspicious lesions, cutis and pectoralis muscle infiltration in PCCT before and after neoadjuvant systemic therapy as assessed by reader 1/2/3. Supplementary Table 3. Number of suspicious axillary lymph nodes in PCCT before and after neoadjuvant systemic therapy as assessed by reader 1/2/3 and histopathologically detected number of lymph node metastasis by axilla surgery after neoadjuvant systemic therapy.
VUDENC: Vulnerability Detection with Deep Learning on a Natural Codebase for Python
Creators: name: Wartschinski, Laura
name: Noller, Yannic
name: Vogel, Thomas
name: Kehrer, Timo
name: Grunske, Lars
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Context: Identifying potential vulnerable code is important to improve the security of our software systems. However, the manual detection of software vulnerabilities requires expert knowledge and is time-consuming, and must be supported by automated techniques. Objective: Such automated vulnerability detection techniques should achieve a high accuracy, point developers directly to the vulnerable code fragments, scale to real-world software, generalize across the boundaries of a specific software project, and require no or only moderate setup or configuration effort. Method: In this article, we present VUDENC (Vulnerability Detection with Deep Learning on a Natural Codebase), a deep learning-based vulnerability detection tool that automatically learns features of vulnerable code from a large and real-world Python codebase. VUDENC applies a word2vec model to identify semantically similar code tokens and to provide a vector representation. A network of long-short-term memory cells (LSTM) is then used to classify vulnerable code token sequences at a fine-grained level, highlight the specific areas in the source code that are likely to contain vulnerabilities, and provide confidence levels for its predictions. Results: To evaluate VUDENC, we used 1,009 vulnerability-fixing commits from different GitHub repositories that contain seven different types of vulnerabilities (SQL injection, XSS, Command injection, XSRF, Remote code execution, Path disclosure, Open redirect) for training. In the experimental evaluation, VUDENC achieves a recall of 78%-87%, a precision of 82%-96%, and an F1 score of 80%-90%. VUDENC's code, the datasets for the vulnerabilities, and the Python corpus for the word2vec model are available for reproduction. Conclusions: Our experimental results suggest...
description: Accepted Manuscript
Presence of identical B-cell clone in both cerebrospinal fluid and tumor tissue in a patient with opsoclonus–myoclonus syndrome associated with neuroblastoma
Creators: name: Noguchi, Kazuhiro
name: Ikawa, Yasuhiro
name: Takenaka, Mika
name: Sakai, Yuta
name: Fujiki, Toshihiro
name: Kuroda, Rie
name: Ikeda, Hiroko
name: Nakada, Satoko
name: Nomura, Kozo
name: Sakai, Seisho
name: Fukuda, Masaki
name: Araki, Raita
name: Takahashi, Yukitoshi
name: Wada, Taizo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Opsoclonus-myoclonus syndrome associated with neuroblastoma (OMS-NB) is a refractory paraneoplastic syndrome which often remain neurological sequelae, and detailed pathogenesis has remained elusive. We encountered a pediatric patient with OMS-NB treated by immunosuppressed therapy who showed anti-glutamate receptor δ2 antibody and increased B-cells in cerebrospinal fluid (CSF), and multiple lymphoid follicles containing abundant Bcells in tumor tissue. Unbiased B-cell receptor repertoire analysis revealed identical B-cell clone was identified as the dominant clone in both CSF and tumor tissue. These identical B-cell clone may contribute to the pathogenesis of OMS-NB. Our results could facilitate the establishment of pathogenesis-based treatment strategies for OMS-NB.
Book Review
Creators: name: Zasiekin, Serhii
Publisher: name: Zenodo
Year: 2018

description: Шмігер Т. (2018). Перекладознавчий аналіз – теоретичні та прикладні аспекти: давня українська література сучасними українською та англійською мовами. Монографія. Київ: Львів: ЛНУ ім. Івана Франка. 510 с. ISBN 978-617-10-0245-6
Extending scientific computing system with structural quantum programming capabilities
Creators: name: Gawron, P.
name: Klamka, J.
name: Miszczak, J. A.
name: Winiarczyk, R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Programming Languages (cs.PL)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: J.2; D.3.3

description: We present a basic high-level structures used for developing quantum programming languages. The presented structures are commonly used in many existing quantum programming languages and we use quantum pseudo-code based on QCL quantum programming language to describe them. We also present the implementation of introduced structures in GNU Octave language for scientific computing. Procedures used in the implementation are available as a package quantum-octave, providing a library of functions, which facilitates the simulation of quantum computing. This package allows also to incorporate high-level programming concepts into the simulation in GNU Octave and Matlab. As such it connects features unique for high-level quantum programming languages, with the full palette of efficient computational routines commonly available in modern scientific computing systems. To present the major features of the described package we provide the implementation of selected quantum algorithms. We also show how quantum errors can be taken into account during the simulation of quantum algorithms using quantum-octave package. This is possible thanks to the ability to operate on density matrices.
Investigation of the role of SASH1 in the regulation of TRAF6-beta-arrestin complex formation
Creators: name: Clayton, Ashley Rebecca
Publisher: name: University of British Columbia
Year: 2014

description: Proper activation and regulation of innate immune signaling pathways and inflammatory responses are essential to efficiently fight infection. Dysregulation of these responses, however, can result in the development of a severe hyper-inflammatory state, ultimately leading to sepsis. The endothelium has been shown to play a critical role in innate immune responses and the pathogenesis of sepsis. In the presence of Gram-negative infection, circulating LPS is recognized by TLR4 expressed on the surface of endothelial cells, mediating downstream activation of pro-inflammatory signal cascades and immune responses. SASH1 has been recently characterized as a novel scaffold protein in the regulation of endothelial TLR4 signaling. The work presented in this thesis further characterizes the role of SASH1 in the regulation of TRAF6 activation within the TLR4 pathway. LPS-induced auto-ubiquitination of TRAF6 is an essential regulatory step in the downstream activation of TLR4-mediated inflammatory signaling. Co-immunoprecipitation analyses confirmed the interaction of endogenous SASH1 with TRAF6 in an LPS-dependent manner in endothelial cells. Furthermore, SASH1 was required for LPS-induced auto-ubiquitination of TRAF6. To further investigate SASH1 function, a yeast two-hybrid approach was employed to identify novel SASH1-interacting proteins. β-arrestin 1 was identified as the top potential interactor of SASH1. Both β-arrestin 1 and β-arrestin 2 have been shown to act as negative regulators of the TLR4 pathway by impairing the oligomerization and auto-ubiquitination of TRAF6. It was speculated that SASH1 may coordinate the interaction of TRAF6 with the β-arrestins to mediate regulation of the TLR4 pathway. Reciprocal co-immunoprecipitation experiments confirmed the interaction of SASH1 with both β-arrestin 1 and β-arrestin 2. SASH1 was also found to interact with β-arrestin 1 in a complex with TRAF6. Further studies aimed to characterize the role of SASH1 in coordinating the interaction of TRAF6 with the β-arrestins. Although knockdown of SASH1 did not modulate TRAF6-β-arrestin binding, the enforced expression of SASH1 was found to specifically impair TRAF6 binding with β-arrestin 1, but not β-arrestin 2. The significance of this isoform-specific regulation remains to be determined. Overall, these studies further investigate the role of SASH1 as a critical scaffold protein in the regulation of the TLR4 pathway.
Low-resolution spectroscopy of main sequence stars belonging to 12 Galactic globular clusters. I. CH and CN band strength variations
Creators: name: Pancino, E.
name: Rejkuba, M.
name: Zoccali, M.
name: Carrera, R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Globular clusters show abundance variations for light elements that are not yet well understood. The preferred explanation involves a self-enrichment scenario, with two subsequent generations of stars. Observations of main sequence stars allow us to investigate the signature of this chemically processed material without the complicating effects of internal mixing. Our goal is to investigate the C-N anti-correlation with low-resolution spectroscopy of 20-50 stars fainter than the first dredge-up in seven globular clusters (NGC288, NGC1851, NGC5927, NGC6352, NGC6388, and Pal12) with different properties. We complemented our observations with 47~Tuc archival data, with four additional clusters from the literature (M15, M22, M55, NGC362), and with additional literature data on NGC288. In this first paper, we measured the strength of CN and CH band indices, and we investigated the anti-correlation and bimodality of these indices. We compared r_CN, the ratio of stars belonging to the CN-strong and weak groups, with 15 different cluster parameters. We clearly see bimodal anti-correlation of the CH and CN band stregths in the metal-rich clusters (Pal12, 47Tuc, NGC6352, NGC5927). Only M15 among the metal-poor clusters shows a clearly bimodal anti-correlation. We found weak correlations (sligthly above 1 sigma) of r_CN with the cluster orbital parameters, present-day total mass, cluster concentration, and age. Our findings support the self-enrichment scenario, and suggest that the occurrence of more than two major generations of stars in a GGC should be rare. Small additional generations (<10-20% of the total) would be difficult to detect with our samples. The first generation, which corresponds to the CN-weak stars, usually contains more stars than the second one (=0.82+/-0.29), as opposed to results based on the Na-O anti-correlations.
description: 18 pages, 10 figures, 1 electronic table, accepted for publication in A&A (language edited version)
Impact of socio-behavioral measures implemented during the SARS-CoV-2 pandemic on the outcomes of febrile neutropenia episodes in pediatric cancer patients: a single center quasi-experimental pre-post study
Creators: name: Nessle, Charles Nathaniel
name: Braun, Tom
name: Chopra, Vineet
name: Choi, Sung Won
name: Mody, Rajen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: During COVID-19, public health measures including masks and social distancing decreased viral upper respiratory infections (URI). Upper respiratory infections are the most common infectious etiology for low-risk pediatric febrile neutropenia (FN). This single-center, quasi-experimental, pre-post study was designed to understand the impact of public health measures on FN admissions and outcomes in the general pediatric oncology population during the COVID (March 2020–February 2021) vs. pre-COVID era (January 2018–February 2020) and their respective respiratory seasons (November–February). Episodes were risk-stratified using a tool recommended by the Children’s Oncology Group. Descriptive and bivariate statistics were used to compare admission characteristics and outcomes. Comparing respiratory seasons, the Covid-era season had 60% fewer URI diagnoses (5/12), while high-risk episodes (63.6% [28/44] vs. 44.2% [23/52]) and intensive care admissions (18.2% [8/44] vs. 3.8% [2/52]) increased. Between eras, URIs were lower in the COVID-era (10.8% [16/148] vs. 19.9% [67/336]; p = 0.01), but admission characteristics and severe outcomes were not different. The impact of public health measures was most prominent during the respiratory season. Despite decreased incidence of URIs, the overall admission characteristics and severe outcomes were minimally impacted due to the brevity of respiratory seasons, but larger studies are warranted.
Additional file 1 of Integrative network pharmacology, transcriptomics, and proteomics reveal the material basis and mechanism of the Shen Qing Weichang Formula against gastric cancer
Creators: name: Wang, Yi
name: Sun, Xiaoyu
name: Ren, Mingming
name: Ma, Fangqi
name: Zhao, Ruohan
name: Zhu, Xiaohong
name: Xu, Yan
name: Cao, Nida
name: Chen, Yuanyuan
name: Pan, Yongfu
name: Zhao, Aiguang
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1 (PDF 638 kb)
Mechanical properties of dental resin composite CAD/CAM blocks
Creators: name: Thornton, Ian
Publisher: name: University of British Columbia
Year: 2014

description: Objective: The goal of this study was to determine the flexural strength (σf), flexural modulus (Ef) and fracture toughness (KIC) of two new commercially available nano-ceramic resin composite CAD/CAM blocks (Lava Ultimate and Enamic) and compare them to those of a widely-used ceramic CAD/CAM block (IPS e.max), that served as a control, in order to evaluate the clinical suitability of the former. Materials and Methods: Fifty bars of Lava Ultimate and Enamic and twenty-five bars of e.max were made for three-point bending testing (to determine σf and Ef). Testing was completed on an Instron machine whereby a force was applied at a constant crosshead speed of 1 mm/min until failure occurred. Twenty-four 6x6x6x12 mm equilateral triangular prisms were fabricated from Lava Ultimate and Enamic and twelve from e.max for fracture toughness (KIC) testing using the notchless triangular prism specimen (NTP) KIC test. Half of the prepared Lava Ultimate and Enamic samples were stored in 37°C water for 30 days prior to testing, to analyze the aging effect. Weibull statistics were used to evaluate the characteristic strength and the reliability of each material. Two-way ANOVA and post-hoc Scheffé comparisons were used to further analyze the results. Results: The σf, Ef and KIC of Lava Ultimate and Enamic were considerably lower than that of IPS e.max. Aging of Lava Ultimate and Enamic lowered the σf by 27 % and 12 % but increased the KIC by 10 % and 40 %, respectively. Aging also significantly lowered Ef of both samples. The σf of Enamic was statistically significantly lower than that of Lava Ultimate, while the Ef of Enamic was statistically significantly higher. Only in the aged samples were significant differences between KIC detected. Conclusion: When compared to conventional resin composites, the presence of ceramic nano-particles in Lava Ultimate and Enamic did not greatly improve σf or KIC of these materials. The flexural modulus of Enamic was greatly improved to levels not seen before in dental resin composites. Based on the mechanical testing results obtained in this study, their consideration and clinical use should be similar to that of conventional dental resin composites.
Do mallard ducks feature in the diet of stoats in an agricultural landscape?
Creators: name: Stewart, Cohen
name: Garrick, Erin
name: McAulay, Jamie
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Computational Biology

description: Research on stoat diet composition in New Zealand has primarily focussed on consumption of indigenous fauna in largely unmodified landscapes. This study used stomach content and stable isotope (δ13C and δ15N) analysis to assess stoat diet in a highly modified agricultural landscape in Southland, New Zealand, focussing on stoat predation of the mallard duck. Stoats were captured in Lochiel, Southland during August–November 2016 and 2017. Stomach content analysis of 26 captured stoats revealed limited stoat predation of mallards (n = 1) and mallard eggs (n = 1). Using liver tissue, stable isotope mixing models suggested that bird eggs on average met between 73 and 85% of stoat metabolic requirements throughout the mallard breeding period. Furthermore, mixing model outputs suggested that bird eggs made up a substantial proportion (77–84%) of stoat assimilated diet early in the mallard breeding period, when mallard eggs are readily available. In contrast, isotope mixing models suggested that mallard ducks/ducklings did not make a large overall contribution to stoat diets (< 3%). This study shows that stoats are an egg predator in the Southland agricultural landscape and mallard eggs may contribute to stoat assimilated diet early in the mallard breeding season before alternative prey items become available.
Modelling TeV gamma-ray emission from the kiloparsec-scale jets of Centaurus A and M87
Creators: name: Hardcastle, M. J.
name: Croston, J. H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The widespread detection of synchrotron X-ray emission from the jets of low-power, nearby radio galaxies implies the presence of electrons at and above TeV energies. In this paper we explore the possibility that the TeV gamma-rays detected from the radio galaxies Cen A and M87, which both have bright, well-studied X-ray jets, are produced at least in part by inverse-Compton scattering of various photon fields by the high-energy electrons responsible for the synchrotron X-rays on kiloparsec scales. We describe a new numerical code that we have developed to carry out inverse-Compton calculations taking account of all the relevant physics and using detailed models of the jets and the photon fields in which they are embedded, and show that existing constraints on the very high-energy (VHE) gamma-ray fluxes of these two objects already place significant constraints on the magnetic field strengths in the jet in Cen A. Finally, we discuss the prospects for constraints on radio galaxy jet physics that may be obtained from observations with the Cerenkov Telescope Array (CTA).
description: 11 pages, 8 figures (some in colour). Accepted by MNRAS
Additional file 2 of Integrative network pharmacology, transcriptomics, and proteomics reveal the material basis and mechanism of the Shen Qing Weichang Formula against gastric cancer
Creators: name: Wang, Yi
name: Sun, Xiaoyu
name: Ren, Mingming
name: Ma, Fangqi
name: Zhao, Ruohan
name: Zhu, Xiaohong
name: Xu, Yan
name: Cao, Nida
name: Chen, Yuanyuan
name: Pan, Yongfu
name: Zhao, Aiguang
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2 (PDF 9561 kb)
Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production
Creators: name: Francotte, Antoine
name: Esson, Raphael
name: Abachin, Eric
name: Vanhamme, Melissa
name: Dobly, Alexandre
name: Carpick, Bruce
name: Uhlrich, Sylvie
name: Dierick, Jean-François
name: Vanhee, Celine
Publisher: name: arXiv
Year: 2022
Subjects: subject: Biomolecules (q-bio.BM)
subject: FOS: Biological sciences

description: The tetanus neurotoxin (TeNT) is one of the most toxic proteins known to man, which prior to the use of the vaccine against the TeNT producing bacteria Clostridium tetani, resulted in a 20 % mortality rate upon infection. The clinical detrimental effects of tetanus have decreased immensely since the introduction of global vaccination programs, which depend on sustainable vaccine production. One of the major critical points in the manufacturing of these vaccines is the stable and reproducible production of high levels of toxin by the bacterial seed strains. In order to minimize time loss, the amount of TeNT is often monitored during and at the end of the bacterial culturing. The different methods that are currently available to assess the amount of TeNT in the bacterial medium suffer from variability, lack of sensitivity, and/or require specific antibodies. In accordance with the consistency approach and the three Rs (3Rs), both aiming to reduce the use of animals for testing, in-process monitoring of TeNT production could benefit from animal and antibody-free analytical tools. In this paper, we describe the development and validation of a new and reliable antibody free targeted LC-MS/MS method that is able to identify and quantify the amount of TeNT present in the bacterial medium during the different production time points up to the harvesting of the TeNT just prior to further upstream purification and detoxification. The quantitation method, validated according to ICH guidelines and by the application of the total error approach, was utilized to assess the amount of TeNT present in the cell culture medium of two TeNT production batches during different steps in the vaccine production process prior to the generation of the toxoid. The amount of TeNT generated under different physical stress conditions applied during bacterial culture was also monitored.
description: manuscript accepted for publication by talanta (DOI 10.1016/j.talanta.2021.122883). In total