Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
Creators: name: Amgad, Mohamed
name: Stovgaard, Elisabeth Specht
name: Balslev, Eva
name: Thagaard, Jeppe
name: Chen, Weijie
name: Dudgeon, Sarah
name: Sharma, Ashish
name: Kerner, Jennifer K.
name: Denkert, Carsten
name: Yuan, Yinyin
name: AbdulJabbar, Khalid
name: Wienert, Stephan
name: Savas, Peter
name: Voorwerk, Leonie
name: Beck, Andrew H.
name: Madabhushi, Anant
name: Hartman, Johan
name: Sebastian, Manu M.
name: Horlings, Hugo M.
name: Hudeček, Jan
name: Ciompi, Francesco
name: Moore, David A.
name: Singh, Rajendra
name: Roblin, Elvire
name: Balancin, Marcelo Luiz
name: Mathieu, Marie-Christine
name: Lennerz, Jochen K.
name: Kirtani, Pawan
name: Chen, I-Chun
name: Braybrooke, Jeremy P.
name: Pruneri, Giancarlo
name: Demaria, Sandra
name: Adams, Sylvia
name: Schnitt, Stuart J.
name: Lakhani, Sunil R.
name: Rojo, Federico
name: Comerma, Laura
name: Badve, Sunil S.
name: Khojasteh, Mehrnoush
name: Symmans, W. Fraser
name: Sotiriou, Christos
name: Gonzalez-Ericsson, Paula
name: Pogue-Geile, Katherine L.
name: Kim, Rim S.
name: Rimm, David L.
name: Viale, Giuseppe
name: Hewitt, Stephen M.
name: Bartlett, John M. S.
name: Penault-Llorca, Frédérique
name: Goel, Shom
name: Lien, Huang-Chun
name: Loibl, Sibylle
name: Kos, Zuzana
name: Loi, Sherene
name: Hanna, Matthew G.
name: Michiels, Stefan
name: Kok, Marleen
name: Nielsen, Torsten O.
name: Lazar, Alexander J.
name: Bago-Horvath, Zsuzsanna
name: Kooreman, Loes F. S.
name: Van Der Laak, Jeroen A. W. M.
name: Saltz, Joel
name: Gallas, Brandon D.
name: Kurkure, Uday
name: Barnes, Michael
name: Salgado, Roberto
name: Cooper, Lee A. D.
name: Hyytiäinen, Aini
name: Hida, Akira I.
name: Thompson, Alastair
name: Lefevre, Alex
name: Gown, Allen
name: Lo, Amy
name: Sapino, Anna
name: Moreira, Andre
name: Richardson, Andrea
name: Vingiani, Andrea
name: Bellizzi, Andrew M.
name: Tutt, Andrew
name: Guerrero-Zotano, Angel
name: Grigoriadis, Anita
name: Ehinger, Anna
name: Garrido-Castro, Anna C.
name: Vincent-Salomon, Anne
name: Laenkholm, Anne-Vibeke
name: Cimino-Mathews, Ashley
name: Srinivasan, Ashok
name: Acs, Balazs
name: Singh, Baljit
name: Calhoun, Benjamin
name: Haibe-Kans, Benjamin
name: Solomon, Benjamin
name: Thapa, Bibhusal
name: Nelson, Brad H.
name: Castaneda, Carlos
name: Ballesteroes-Merino, Carmen
name: Criscitiello, Carmen
name: Boeckx, Carolien
name: Colpaert, Cecile
name: Quinn, Cecily
name: Chennubhotla, Chakra S.
name: Swanton, Charles
name: Solinas, Cinzia
name: Hiley, Crispin
name: Drubay, Damien
name: Bethmann, Daniel
name: Dillon, Deborah A.
name: Larsimont, Denis
name: Sabanathan, Dhanusha
name: Peeters, Dieter
name: Zardavas, Dimitrios
name: Höflmayer, Doris
name: Johnson, Douglas B.
name: Thompson, E. Aubrey
name: Brogi, Edi
name: Perez, Edith
name: ElGabry, Ehab A.
name: Blackley, Elizabeth F.
name: Reisenbichler, Emily
name: Bellolio, Enrique
name: Chmielik, Ewa
name: Gaire, Fabien
name: Andre, Fabrice
name: Lu, Fang-I
name: Azmoudeh-Ardalan, Farid
name: Gruosso, Forbius Tina
name: Peale, Franklin
name: Hirsch, Fred R.
name: Klaushen, Frederick
name: Acosta-Haab, Gabriela
name: Farshid, Gelareh
name: Van Den Eynden, Gert
name: Curigliano, Giuseppe
name: Floris, Giuseppe
name: Broeckx, Glenn
name: Koeppen, Harmut
name: Haynes, Harry R.
name: McArthur, Heather
name: Joensuu, Heikki
name: Olofsson, Helena
name: Cree, Ian
name: Nederlof, Iris
name: Frahm, Isabel
name: Brcic, Iva
name: Chan, Jack
name: Hall, Jacqueline A.
name: Ziai, James
name: Brock, Jane
name: Wesseling, Jelle
name: Giltnane, Jennifer
name: Lemonnier, Jerome
name: Zha, Jiping
name: M. Ribeiro, Joana
name: Carter, Jodi M.
name: Hainfellner, Johannes
name: Quesne, John Le
name: Juco, Jonathan W.
name: Reis-Filho, Jorge
name: Van Den Berg, Jose
name: Sanchez, Joselyn
name: Sparano, Joseph
name: Cucherousset, Joël
name: Araya, Juan Carlos
name: Adam, Julien
name: Balko, Justin M.
name: Saeger, Kai
name: Siziopikou, Kalliopi
name: Willard-Gallo, Karen
name: Sikorska, Karolina
name: Weber, Karsten
name: Steele, Keith E.
name: Emancipator, Kenneth
name: El Bairi, Khalid
name: Blenman, Kim R. M.
name: Allison, Kimberly H.
name: Van De Vijver, Koen K.
name: Korski, Konstanty
name: Pusztai, Lajos
name: Buisseret, Laurence
name: Shi, Leming
name: Shi-Wei, Liu
name: Molinero, Luciana
name: Estrada, M. Valeria
name: Van Seijen, Maartje
name: Lacroix-Triki, Magali
name: Cheang, Maggie C. U.
name: Bakir, Maise Al
name: Van De Vijver, Marc
name: Dieci, Maria Vittoria
name: Rebelatto, Marlon C.
name: Piccart, Martine
name: Goetz, Matthew P.
name: Preusser, Matthias
name: Sanders, Melinda E.
name: Regan, Meredith M.
name: Christie, Michael
name: Misialek, Michael
name: Ignatiadis, Michail
name: De Maaker, Michiel
name: Van Bockstal, Mieke
name: Castillo, Miluska
name: Harbeck, Nadia
name: Tung, Nadine
name: Laudus, Nele
name: Sirtaine, Nicolas
name: Burchardi, Nicole
name: Ternes, Nils
name: Radosevic-Robin, Nina
name: Gluz, Oleg
name: Grimm, Oliver
name: Nuciforo, Paolo
name: Jank, Paul
name: Jelinic, Petar
name: Watson, Peter H.
name: Francis, Prudence A.
name: Russell, Prudence A.
name: Pierce, Robert H.
name: Hills, Robert
name: Leon-Ferre, Roberto
name: De Wind, Roland
name: Shui, Ruohong
name: Declercq, Sabine
name: Leung, Sam
name: Tabbarah, Sami
name: Souza, Sandra C.
name: O’Toole, Sandra
name: Swain, Sandra
name: Willis, Scooter
name: Ely, Scott
name: Kim, Seong- Rim
name: Bedri, Shahinaz
name: Irshad, Sheeba
name: Liu, Shi-Wei
name: Hendry, Shona
name: Bianchi, Simonetta
name: Bragança, Sofia
name: Paik, Soonmyung
name: Fox, Stephen B.
name: Luen, Stephen J.
name: Naber, Stephen
name: Luz, Sua
name: Fineberg, Susan
name: Soler, Teresa
name: Gevaert, Thomas
name: D’Alfons, Timothy
name: John, Tom
name: Sugie, Tomohagu
name: Bossuyt, Veerle
name: Manem, Venkata
name: Cámaea, Vincente Peg
name: Tong, Weida
name: Yang, Wentao
name: Tran, William T.
name: Wang, Yihong
name: Allory, Yves
name: Husain, Zaheed
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Review Article
/692/53/2422
/631/67/580
/631/67/1347
/692/4028/67/1857
/631/67/2321
review-article

description: Funder: U.S. Department of Health &amp; Human Services | NIH | National Cancer Institute (NCI)
description: Funder: National Center for Research Resources under award number 1 C06 RR12463-01, VA Merit Review Award IBX004121A from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service, the DOD Prostate Cancer Idea Development Award (W81XWH-15-1-0558), the DOD Lung Cancer Investigator-Initiated Translational Research Award (W81XWH-18-1-0440), the DOD Peer Reviewed Cancer Research Program (W81XWH-16-1-0329), the Ohio Third Frontier Technology Validation Fund, the Wallace H. Coulter Foundation Program in the Department of Biomedical Engineering and the Clinical and Translational Science Award Program (CTSA) at Case Western Reserve University.
description: Funder: Susan G Komen Foundation (CCR CCR18547966) and a Young Investigator Grant from the Breast Cancer Alliance.
description: Funder: The Canadian Cancer Society
description: Funder: Breast Cancer Research Foundation (BCRF), Grant No. 17-194
description: Abstract: Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring.