cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of cell wall integrity signalling in Chlamydomonas reinhardtii
Creators: name: Cronmiller, Evan Thomas Stephen
Publisher: name: University of British Columbia
Year: 2018

description: A fundamental aspect of plant survival is the development of a resilient cell wall. Throughout the life cycle of the unicellular alga Chlamydomonas reinhardtii, the cell wall is continuously synthesized and remodelled. When cells are starved of nitrogen, they differentiate into gametes and enter the sexual (meiotic) phase. In doing this, mating gamete cells shed their cell walls via gametolysin, fuse their naked protoplasts, and build an exceptionally hardy zygote cell wall. Previous research on the sexual life cycle has focused on regulatory events upstream of the mating reaction, i.e. gametogenesis, and downstream of cell fusion during zygote development. As such, we don’t yet understand how cells are responding to wall shedding at the onset of the mating reaction. A recent transcriptome analysis has reported a set of genes that are specifically regulated by gametolysin-mediated wall shedding, consisting of two major functional categories – protein processing-related and cell wall-related. The research presented here attempts to understand the level at which these genes are regulated and establishes three hypotheses for what the ‘trigger’ of their regulation might be. Using a suite of target genes as representative factors of the gametolysin-mediated event, we performed promoter-reporter and mRNA expression analyses in several treatment conditions and cell lines to examine this regulation. We found both target genes and their respective promoters are strongly induced by gametolysin, indicating transcription-level regulation. When cells were pre-treated with a protein synthesis inhibitor prior to gametolysin, we observed differential effects on the transcription of our target genes, suggesting multiple regulatory proteins control this event. We also observed that an ER stress response likely helps to regulate cell wall recovery, as a stress response-impaired mutant showed diminished transcript expression following gametolysin treatment. Cell wall-defective mutants were found to have a negligible response to gametolysin, but expressed our target genes constitutively, indicating the need for cells to maintain a cell wall. Early investigations of our hypotheses for the ‘trigger’ of the gametolysin-mediated response suggests a minor role for osmotic stress signalling and that sensing the condition of the cell wall is likely the primary ‘trigger.’
title: The company she keeps : The social and interpersonal construction of girls same sex friendships
Creators: name: Hey, V
Publisher: name: University of Kent
Year: 1988

description: This thesis begins a critical analysis of girls' 'private' interpersonal and social relations as they are enacted within two school settings. It is the study of these marginal subordinated worlds productivity of forms of femininity which provides the main narrative of this project. I seek to understand these processes of (best) friendship construction through a feminist multi-disciplinary frame, drawing upon cultural studies, psychoanalysis and accounts of gender politics. I argue that the investments girls bring to their homosocial alliances and boundary drawing narry a psychological compulsion which is complexly connected to their own experiences within the mother/daughter bond as well as reflecting positively an immense social debt to the permissions girls have to be nurturant and ; negatively their own reproduction of oppressive exclusionary practices. Best friendship in particular gives girls therefore, the experience of 'monogamy' continuous of maternal/daughter identification, reminiscent of their positioning inside monopolistic forms of heterosexuality. But these subcultures also represent a subversive discontinuity to the public dominance of boys/teachers/adults in schools and to the ideologies and practices of heterosociality and heterosexuality. By taking seriously their transmission of the values of friendship in their chosen form of notes and diaries for example, I was able to access the means whereby they were able to resist their surveillance and control by those in power over them. I conclude by arguing that it is through a recognition of the valency of these indivisiblly positive and negative aspects to girls cultures that Equal Opportunities practitioners must begin if they are serious about their ambitions. Methods have to be made which enable girls to transfer their 'private' solidarities into the 'public' realm, which unquestionably demands contesting with them the causes and consequences of their implication in the divisions which also contaminate their lives and weaken them.
Anion-lnduced Fluorescence Quenching of a New Zwitterionic Biacridine Derivative
Creators: name: Werner, Tobias
name: Fähnrich, Karsten
name: Huber, Christian
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 1999
Subjects: subject: 540 Chemie

description: The effect of halides and different buffer anions on the quenching of the fluorescence of the new probe 10,10′-bis(3-sulfopropyl)-9,9′-biacridine (SPBA) has been studied using fluorescence and decay time measurements. The linearity of the Stern-Volmer plot indicates that fluorescence quenching by halides can be described reasonably well by a single-exponential decay with a K of 4.06 times 10⁶M⁻¹s⁻¹for chloride, 7.83 times 10⁶M⁻¹s⁻¹for bromide and 1.12 times 10⁷M⁻¹s⁻¹for iodide. We have found that SPBA is collisionally quenched also by the buffers 3-(N-mor-pholino)propanesulfonic acid (MOPS) and N-2-hydroxy-ethylpiperazine-N′-ethansulfonic acid (HEPES). The bi-molecular rate constants are 1.67 × 10⁶M⁻¹s⁻¹for HEPES and 1.44 times 10⁶M⁻¹s⁻¹for MOPS.
Building reliable and generalizable clerkship competency assessments: Impact of ‘hawk-dove’ correction
Creators: name: Santen, Sally A.
name: Ryan, Michael
name: Helou, Marieka A.
name: Richards, Alicia
name: Perera, Robert A.
name: Haley, Kellen
name: Bradner, Melissa
name: Rigby, Fidelma B.
name: Park, Yoon Soo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Systematic differences among raters’ approaches to student assessment may result in leniency or stringency of assessment scores. This study examines the generalizability of medical student workplace-based competency assessments including the impact of rater-adjusted scores for leniency and stringency. Data were collected from summative clerkship assessments completed for 204 students during 2017–2018 the clerkship at a single institution. Generalizability theory was used to explore variance attributed to different facets (rater, learner, item, and competency domain) through three unbalanced random-effects models by clerkship including applying assessor stringency-leniency adjustments. In the original assessments, only 4–8% of the variance was attributed to the student with the remainder being rater variance and error. Aggregating items to create a composite score increased variability attributable to the student (5–13% of variance). Applying a stringency-leniency (‘hawk-dove’) correction substantially increased the variance attributed to the student (14.8–17.8%) and reliability. Controlling for assessor leniency/stringency reduced measurement error, decreasing the number of assessments required for generalizability from 16–50 to 11–14. Similar to prior research, most of the variance in competency assessment scores was attributable to raters, with only a small proportion attributed to the student. Making stringency-leniency corrections using rater-adjusted scores improved the psychometric characteristics of assessment scores.
title: CEO Attributes and Firm Performance
Creators: name: Larcker, David F.
name: Tayan, Brian
Publisher: name: Corporate Governance Research Initiative
Year: 2016

description: This Research Spotlight provides a summary of the academic literature on the influence that CEOs have on company outcomes (performance and risk). It reviews the evidence of: The contribution of the CEO to overall company performance, the relation between previous managerial experience and future performance, the relation between personal attributes and performance, the relation between personality and performance, and factors that might influence risk tolerance. This Research Spotlight expands upon issues introduced in the Quick Guide “CEO Succession Planning.”
Das metastasierende differenzierte Schilddrüsenkarzinom. Diagnostische Treffsicherheit des Thyreoglobulin-RIA im Vergleich zur 13'J-Ganzkörperszintigraphie = Metastatic differentiated thyroid cancer. Diagnostic accuracy of thyroglobulin-RIA in comparison with 131I-whole body scintigraphy
Creators: name: Reiners, C.
name: Reimann, J.
name: Schäffer, R.
name: Baum, K.
name: Becker, W.
name: Eilles, Christoph
name: Gerhards, W.
name: Schick, F.
name: Spiegel, W.
name: Wiedemann, W.
Publisher: name: Universität Regensburg
Year: 1984
Subjects: subject: 610 Medizin
subject: Adenocarcinoma/radionuclide imaging
subject: Adult
subject: Aged
subject: Bone Neoplasms/secondary
subject: Carcinoma/radionuclide imaging
subject: Carcinoma, Papillary/radionuclide imaging
subject: Female
subject: Humans
subject: Iodine Radioisotopes/diagnostic use
subject: Lung Neoplasms/secondary
subject: Male
subject: Middle Aged
subject: Neoplasm Metastasis/radionuclide imaging
subject: Radioimmunoassay
subject: Thyroglobulin/blood
subject: Thyroid Neoplasms/radionuclide imaging

description: In a retrospective analysis in patients with differentiated thyroid carcinoma, the diagnostic validities of 131I whole-body scans and radioimmunologic determinations of thyroglobulin (hTg) are compared with special regard to late metastases. Metastases were found in 83 out of 311 patients with differentiated thyroid carcinoma. In two thirds of the cases, these were primary metastases while in the remaining third of the cases, metastases developed in later follow-up with a mean time of latency of 3.3 years. While about 70% of the early metastases could bei detected by 131I scintigraphy, this percentage amounted to only 40% in late metastases. With a diagnostic sensitivity of 90%, hTg-RIA was clearly superior in the detection of early as well as of late metastases. hTg was measurable, however, only in iatrogenous hypothyroidism in 4 out of 49 cases. Based on these results and an analysis of the literature, a program for follow-up of differentiated thyroid carcinoma is proposed. The hTg-RIA is thereby used as an alternative to 131I scintigraphy in the late phase of follow-up after complete ablation of any thyroid tissue.
Modified Dispersion Relations and Noncommutative Geometry lead to a finite Zero Point Energy
Creators: name: Garattini, Remo
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute Zero Point Energy in a spherically symmetric background with the help of the Wheeler-DeWitt equation. This last one is regarded as a Sturm-Liouville problem with the cosmological constant considered as the associated eigenvalue. The graviton contribution, at one loop is extracted wit the help of a variational approach together with Gaussian trial functionals. The divergences handled with a zeta function regularization are compared with the results obtained using a Noncommutative Geometry (NCG) and Modified Dispersion Relations (MDR). In both NCG and MDR no renormalization scheme is necessary to remove infinities in contrast to what happens in conventional approaches.
description: Contribution written for the Proceedings of Frontiers of Fundamental Physics [FFP11], 6-9 July 2010, Paris. 12 Pages
The KAIROS Blanket Exercise: Engaging Indigenous ways of knowing to foster critical consciousness in medical education
Creators: name: Herzog, Lindsay S.
name: Wright, Sarah R.
name: Pennington, Jason J.
name: Richardson, Lisa
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Indigenous Peoples across Turtle Island (North America) experience ongoing health disparities tied to the effects of colonization and persistent racism toward Indigenous Peoples. Educating future clinicians to develop a critical consciousness is an important way to work toward cultural safety and improve the health care experiences of Indigenous patients. The present study evaluated the ability of the KAIROS Blanket Exercise (KBE) to foster critical consciousness. Two hundred thirteen medical students at the University of Toronto participated in the KBE. Subsequently, 174 students completed a paper evaluation, designed to capture concepts of cultural safety and critical consciousness. Data were analyzed using quantitative and qualitative methods to identify shifts in perspectives. The majority of students reported the exercise altered the way they viewed those from backgrounds different from their own, and comments regarding bias, power and privilege were highlighted throughout the responses. Engaging in critical reflection through dialogue and revealing the complex sociopolitical context of Indigenous Peoples’ history were emphasized as central to this transformation. Following participation in the KBE, medical students demonstrated a shift in their perspectives. This suggests that creating curricular space for critical pedagogy may be effective in fostering critical consciousness, ultimately encouraging reflexive practice and social action.
Novel optical pH-sensor based on a boradiaza-indacene derivative
Creators: name: Werner, T.
name: Huber, Ch.
name: Heinl, S.
name: Kollmannsberger, M.
name: Daub, J.
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 540 Chemie

description: A pH-optode is described based on 1, 3, 5, 7-tetramethyl-8-(4-dimethylamino)-4-difluorobora-3a, 4a-diaza-(s)-indacene (1) immobilized in a hydrogel matrix. Its uncharged form is non-fluorescent, whereas the protonated form displays strong emission. The quenching of the emission can be mechanistically explained by a PET (photoinduced electron transfer) from the dimethylamino group to the fluorophore. The perpendicular configuration at the C(8)-aryl bond contributes to the efficiency of the on/off-switching behavior. Incorporation of the dye into a hydrogel matrix results in a transparent sensor membrane which can be used to measure the pH in the range of 1-3. The sensor shows high signal intensity, good reproducibility, and the response characteristic is stable over hours of operation even at low pH-values.
Magnetic Branes Supported by Nonlinear Electromagnetic Field
Creators: name: Hendi, Seyed Hossein
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Considering the nonlinear electromagnetic field coupled to Einstein gravity in the presence of cosmological constant, we obtain a new class of $d$-dimensional magnetic brane solutions. This class of solutions yields a spacetime with a longitudinal nonlinear magnetic field generated by a static source. These solutions have no curvature singularity and no horizons but have a conic geometry with a deficit angle $δϕ$. We investigate the effects of nonlinearity on the metric function and deficit angle and also find that for the special range of the nonlinear parameter, the solutions are not asymptotic AdS. We generalize this class of solutions to the case of spinning magnetic solutions, and find that when one or more rotation parameters are nonzero, the brane has a net electric charge which is proportional to the magnitude of the rotation parameters. Then, we use the counterterm method and compute the conserved quantities of these spacetimes. Finally, we obtain a constrain on the nonlinear parameter, such that the nonlinear electromagnetic field is conformally invariant.
description: 15 pages, one eps figure
The mid-infrared diameter of W Hydrae
Creators: name: Zhao-Geisler, R.
name: Quirrenbach, A.
name: Koehler, R.
name: Lopez, B.
name: Leinert, C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Mid-infrared (8-13 microns) interferometric data of W Hya were obtained with MIDI/VLTI between April 2007 and September 2009, covering nearly three pulsation cycles. The spectrally dispersed visibility data of all 75 observations were analyzed by fitting a circular fully limb-darkened disk (FDD) model to all data and individual pulsation phases. Asymmetries were studied with an elliptical FDD. Modeling results in an apparent angular FDD diameter of W Hya of about (80 +/- 1.2) mas (7.8 AU) between 8 and 10 microns, which corresponds to an about 1.9 times larger diameter than the photospheric one. The diameter gradually increases up to (105 +/- 1.2) mas (10.3 AU) at 12 microns. In contrast, the FDD relative flux fraction decreases from (0.85 +/- 0.02) to (0.77 +/- 0.02), reflecting the increased flux contribution from a fully resolved surrounding silicate dust shell. The asymmetric character of the extended structure could be confirmed. An elliptical FDD yields a position angle of (11 +/- 20) deg and an axis ratio of (0.87 +/- 0.07). A weak pulsation dependency is revealed with a diameter increase of (5.4 +/- 1.8) mas between visual minimum and maximum, while detected cycle-to-cycle variations are smaller. W Hya's diameter shows a behavior that is very similar to the Mira stars RR Sco and S Ori and can be described by an analogous model. The constant diameter part results from a partially resolved stellar disk, including a close molecular layer of H2O, while the increase beyond 10 microns can most likely be attributed to the contribution of a spatially resolved nearby Al2O3 dust shell.
description: 18 pages, 16 figures
Thermodynamics of Rotating Black Branes in Gauss-Bonnet-nonlinear Maxwell Gravity
Creators: name: Hendi, Seyed Hossein
name: Panah, Behzad Eslam
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider the Gauss-Bonnet gravity in the presence of a new class of nonlinear electromagnetic field, namely, power Maxwell invariant. By use of a suitable transformation, we obtain a class of real rotating solutions with $k$ rotation parameters and investigate some properties of the solutions such as existence of singularity(ies) and asymptotic behavior of them. Also, we calculate the finite action, thermodynamic and conserved quantities of the solutions and using the the Smarr-type formula to check the first law of thermodynamics.
description: 15 pages
Know thyself: Development and validation of self-awareness of teaching skills (SATS) measuring instrument for medical teachers
Creators: name: Gul, Seema
name: Mahboob, Usman
name: Yasmin, Rahila
name: Khan, Rehan Ahmad
name: Baseer, Najma
name: Abrar, Saidul
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Self-awareness is measured previously in the higher education however not specifically in relation to ‘effectiveness of teaching’ thus leaving a gap in the literature. To develop and validate an instrument for medical teachers to measure the self-awareness of their teaching. This was an instrument development multiphase mixed-method study design, based on Brookfield’s four lenses theory. The instrument was validated after administering content validity, cognitive pretesting, confirmatory factor analysis and reliability analysis. Contrasting groups’ method of standard setting was used to determine the cut-off scores for the levels of self-awareness of medical teachers. A 26-item preliminary draft instrument was reduced to a 19-item final instrument having four themes, that is; self-reflection, communication with students, student feedback, and peer review. Content Validity Scale was 0.92. Confirmatory factor analysis yielded a model with a good-to-excellent fit and an internal consistency of 0.85. The cut-off values were calculated to be 79%, 70%, 59%, and 53% for excellent, good, average and poor self-awareness of teaching skills respectively. The Self-awareness of the teaching skills instrument has excellent validity and good reliability in measuring the self-awareness of teaching skills of medical teachers.
The KAIROS Blanket Exercise: Engaging indigenous ways of knowing to foster critical consciousness in medical education
Creators: name: Herzog, Lindsay S.
name: Wright, Sarah R.
name: Pennington, Jason J.
name: Richardson, Lisa
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Purpose: Indigenous Peoples across Turtle Island (North America) experience ongoing health disparities tied to the effects of colonization and persistent racism toward Indigenous Peoples. Educating future clinicians to develop a critical consciousness is an important way to work toward cultural safety and improve the health care experiences of Indigenous patients. The present study evaluated the ability of the KAIROS Blanket Exercise (KBE) to foster critical consciousness. Methods: Two hundred thirteen medical students at the University of Toronto participated in the KBE. Subsequently, 174 students completed a paper evaluation, designed to capture concepts of cultural safety and critical consciousness. Data were analyzed using quantitative and qualitative methods to identify shifts in perspectives. Results: The majority of students reported the exercise altered the way they viewed those from backgrounds different from their own, and comments regarding bias, power and privilege were highlighted throughout the responses. Engaging in critical reflection through dialogue and revealing the complex sociopolitical context of Indigenous Peoples’ history were emphasized as central to this transformation. Conclusions: Following participation in the KBE, medical students demonstrated a shift in their perspectives. This suggests that creating curricular space for critical pedagogy may be effective in fostering critical consciousness, ultimately encouraging reflexive practice and social action.
Creation of Coherent Superposition States in Inhomogeneously Broadened Media with Relaxation
Creators: name: Sandor, N.
name: Bakos, J. S.
name: Sörlei, Zs.
name: Djotyan, G. P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose and analyze a scheme for "on demand" creation of coherent superposition of meta-stable states in a tripod-structured atom using frequency-chirped laser pulses. Negligible excitation of the atoms during the creation of the superposition states is a priority in our consideration. The underlying physics of the scheme is explained using the formalism of adiabatic states. By numerically solving master equation for the density matrix operator, we analyze the influence of the spontaneous decay and transverse relaxation on the efficiency of the creation of superposition states. We show that the proposed scheme is robust against small-to-medium variations of the parameters of the laser pulses. We provide a detailed analysis of the effect of the inhomogeneous (Doppler-) broadening on the efficiency of the coherence creation and show that the proposed scheme may be equally efficient in both homogeneously and Doppler-broadened media.
Investigation of potential-sensitive fluorescent dyes for application in nitrate sensitive polymer membranes
Creators: name: Mohr, Gerhard J.
name: Lehmann, Frank
name: Östereich, Ralf
name: Murkovic, Ivana
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 540 Chemie

description: The applicability of various potential-sensitive dyes (PSD) for optical sensing of anions is reported. Specifically, nitrate-responsive polymer membranes have been developed which are composed of a plasticized polymer, an anion exchange catalyst, and a fluorescent dye. On exposure to nitrate, the fluorescence intensity of such membranes increases, while the wavelengths of the excitation and emission maxima remain virtually unchanged. The membranes typically are 2–4 μm thick and exhibit highest sensitivity to nitrate in the 2 to 200 mgl⁻¹ range. Signal changes on exposure to 100 mmol/1 nitrate can be as high as +300%. The detection limit is 0.2 mgl⁻¹. The cationic PSD octadecyl acridine organe was tested in combination with a tin-organic and an indium-organic anion carrier rather than with tridodecylmethylammonium chloride, but both carriers were found to display no improved selectivity.
title: CEO Turnover
Creators: name: Larcker, David F.
name: Tayan, Brian
Publisher: name: Corporate Governance Research Initiative
Year: 2016

description: This Research Spotlight provides a summary of the academic literature on relation between CEO performance and turnover. It reviews the evidence of: The relation between performance and likelihood of termination, the relation between board attributes and likelihood of termination, and other factors that might influence CEO performance oversight. This Research Spotlight expands upon issues introduced in the Quick Guide “CEO Succession Planning.”
Chameleonic dilaton, nonequivalent frames, and the cosmological constant problem in quantum string theory
Creators: name: Zanzi, Andrea
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The chameleonic behaviour of the String theory dilaton is suggested. Some of the possible consequences of the chameleonic string dilaton are analyzed in detail. In particular, (1) we suggest a new stringy solution to the cosmological constant problem and (2) we point out the non-equivalence of different conformal frames at the quantum level. In order to obtain these results, we start taking into account the (strong coupling) string loop expansion in the string frame (S-frame), therefore the so-called form factors are present in the effective action. The correct Dark Energy scale is recovered in the Einstein frame (E-frame) without unnatural fine-tunings and this result is robust against all quantum corrections, granted that we assume a proper structure of the S-frame form factors in the strong coupling regime. At this stage, the possibility still exists that a certain amount of fine-tuning may be required to satisfy some phenomenological constraints. Moreover in the E-frame, in our proposal, all the interactions are switched off on cosmological length scales (i.e. the theory is IR-free), while higher derivative gravitational terms might be present locally (on short distances) and it remains to be seen whether these facts clash with phenomenology. A detailed phenomenological analysis is definitely necessary to clarify these points.
title: Internal vs. External CEOs
Creators: name: Larcker, David F.
name: Tayan, Brian
Publisher: name: Corporate Governance Research Initiative
Year: 2016

description: This Research Spotlight provides a summary of the academic literature on internal and external CEOs. It reviews the evidence of: Trends in hiring external CEOs, operating condition of companies that hire internal and external CEOs, stock market reaction to hiring external CEOs, and relative performance of internal and external CEOs. This Research Spotlight expands upon issues introduced in the Quick Guide “CEO Succession Planning.”
Sol–gel based glucose biosensors employing optical oxygen transducers, and a method for compensating for variable oxygen background
Creators: name: Wolfbeis, Otto S.
name: Oehme, Ines
name: Papkovskaya, Natalya
name: Klimant, Ingo
Publisher: name: Universität Regensburg
Year: 2000
Subjects: subject: Glucose biosensor; Sol–gel; Fluorescence quenching; Oxygen sensor; Calibration
subject: 540 Chemie

description: Various types of thin-film glucose biosensors based on the use of the enzyme glucose oxidase (GOx) have been developed. The luminescent oxygen probe Ru(dpp) — whose emission is quenched by oxygen — is used to measure the consumption of oxygen. Three different combinations of oxygen transducer and sol–gel immobilized GOx were tested. In the first, GOx was sandwiched between a sol–gel layer doped with Ru(dpp) and a second sol–gel layer composed of pure sol–gel (the ‘sandwich’ configuration). In the second, a sol–gel layer doped with Ru(dpp) was covered with sol–gel entrapped GOx (the ‘two-layer configuration’). In the third, both GOx and a sol–gel powder containing GOx were incorporated into a single sol–gel phase (the ‘powder configuration’). In all cases, it was found to be essential to add sorbitol which results in a more porous sol–gel in which diffusion is not impaired. The sandwich configuration provides the highest enzyme activity and the largest dynamic range (0.1–15 mM), but suffers from a distinct decrease in sensitivity upon prolonged use. The two-layer configuration has the fastest response time (t9050 s), while the ‘powder configuration’ provides the best operational lifetime. The storage stability of all configurations exceeds 4 months if stored at 4°C. In an Appendix, equations are derived which describe the response of such sensors, how the effect of varying oxygen supply can be compensated for by making use of two sensors, one sensitive to oxygen only, the other to both oxygen and glucose, and how such sensors can be calibrated using two calibrators only.
Yangian symmetry of boundary scattering in AdS/CFT and the explicit form of bound state reflection matrices
Creators: name: Palla, Laszlo
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The reflection matrices of multi magnon bound states are obtained explicitely by exploiting the Yangian symmetry of boundary scattering on the Y=0 maximal giant graviton brane.
description: 13 pages
Upstanding Rashba spin in honeycomb lattices: Electrically reversible surface spin polarization
Creators: name: Liu, Ming-Hao
name: Chang, Ching-Ray
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 530 Physik
subject: 73.20.At, 73.63.−b, 71.70.Ej

description: The spin-split states subject to Rashba spin-orbit coupling in two-dimensional systems have long been accepted as pointing inplane and perpendicular to the corresponding wave vectors. This is in general true for free-electron model, but exceptions do exist elsewhere. Within the tight-binding model, we unveil the unusual upstanding behavior of those Rashba spins around K̅ and K̅ ′ points in honeycomb lattices. Our calculation (i) explains the recent experiment of the Tl/Si(111)-(1×1) surface alloy [K. Sakamoto et al., Phys. Rev. Lett. 102, 096805 (2009)], where abrupt upstanding spin states near K̅ are observed and (ii) predicts an electrically reversible out-of-plane surface spin polarization.
Finite-size analysis of continuous-variable quantum key distribution
Creators: name: Leverrier, Anthony
name: Grosshans, Frédéric
name: Grangier, Philippe
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The goal of this paper is to extend the framework of finite size analysis recently developed for quantum key distribution to continuous-variable protocols. We do not solve this problem completely here, and we mainly consider the finite size effects on the parameter estimation procedure. Despite the fact that some questions are left open, we are able to give an estimation of the secret key rate for protocols which do not contain a postselection procedure. As expected, these results are significantly more pessimistic than the ones obtained in the asymptotic regime. However, we show that recent continuous-variable protocols are able to provide fully secure secret keys in the finite size scenario, over distances larger than 50 km.
description: 12 pages, 4 figures, updated references
Polynomial invariants for discrimination and classification of four-qubit entanglement
Creators: name: Viehmann, Oliver
name: Eltschka, Christopher
name: Siewert, Jens
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 530 Physik
subject: 03.67.Mn

description: The number of entanglement classes in stochastic local operations and classical communication (SLOCC) classifications increases with the number of qubits and is already infinite for four qubits. Criteria for explicitly discriminating and classifying pure states of four and more qubits are highly desirable and therefore at the focus of intense theoretical research. We develop a general criterion for the discrimination of pure N-partite entangled states in terms of polynomial SL(d,C)⊗N invariants. By means of this criterion, existing SLOCC classifications of four-qubit entanglement are reproduced. Based on this we propose a polynomial classification scheme in which entanglement types are identified through “tangle patterns.” This scheme provides a practicable way to classify states of arbitrary multipartite systems. Moreover, the use of polynomials induces a corresponding quantification of the different types of entanglement.
Merger Dynamics in Three-Agent Games
Creators: name: Rador, T.
name: Derici, R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present the effect of mergers in the dynamics of the three-agent model studied by Ben-Naim, Kahng and Kim and by Rador and Mungan. Mergers are possible in three-agent games because two agents can combine forces against the third player and thus increase their probability to win a competition. We implement mergers in this three-agent model via resolving merger and no-merger units of competition in terms of a two-agent unit. This way one needs only a single parameter which we have called the competitiveness parameter. We have presented an analytical solution in the fully competitive limit. In this limit the score distribution of agents is stratified and self-similar.
Growth control of cultured microglia
Creators: name: Ganter, S.
name: Northoff, H.
name: Männel, Daniela N.
name: Gebicke-Härter, P. J.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin
subject: Acid Anhydride Hydrolases
subject: Aldosterone/pharmacology
subject: Animals
subject: Animals, Newborn
subject: Astrocytes/physiology
subject: Brain/physiology
subject: Cell Communication
subject: Cell Division/drug effects
subject: Cells, Cultured
subject: DNA/biosynthesis
subject: Dexamethasone/pharmacology
subject: Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
subject: Hydrocortisone/pharmacology
subject: Interleukin-1/biosynthesis
subject: Interleukin-3/pharmacology
subject: Interleukin-6/biosynthesis
subject: Kinetics
subject: Lipopolysaccharides/pharmacology
subject: Macrophages/physiology
subject: Mesoderm
subject: Phosphoric Monoester Hydrolases/metabolism
subject: Progesterone/pharmacology
subject: Rats
subject: Rats, Wistar
subject: Thiamine Pyrophosphatase/metabolism
subject: Thymidine/metabolism
subject: Tumor Necrosis Factor-alpha/biosynthesis

description: Microglia, the resident macrophages of the brain, typically react to injuries or chronic diseases with proliferation and expression of differentiated features, such as production of cytokines associated with inflammatory events. Regulation and control of microglial cytokine expression, therefore, is a major focus of scientific interest. It has been shown that GMCSF and Il-3 are potent mitogens for microglia. Moreover, Il-3 and other cytokines are products of microglia. It is shown here that interleukin-1 (Il-1) as well as tumor necrosis factor (TNF alpha) increased microglial proliferation in mixed astrocyte-microglial cultures but had no mitogenic effects on isolated microglia. Lipopolysaccharide (LPS), the bacterial endotoxin, irreversibly inhibited microglial cell division in both mixed astrocyte-microglial cultures and in isolated microglial cultures. By contrast, the corticosteroids hydrocortisone and aldosterone and the synthetic glucocorticoid dexamethasone reversibly inhibited microglial proliferation. They also antagonized the stimulatory effects of Il-3 and granulocyte macrophage colony-stimulating factor (GMCSF). Estradiol and progesterone had no significant effects on mixed cultures but inhibited microglial proliferation in isolated cultures. Conditioned media from mixed cultures, isolated cultures, from the WEHI-2B cell line, or from fresh (serum-supplemented) media stimulated microglial proliferation to various extents. In summary, cytokine-mediated microglial proliferation can be down-regulated by a variety of steroid hormones. Along with their unimpaired access to brain cells in general, corticosteroids likely maintain an inhibitory tonus on microglial proliferation. It is hypothesized that this inhibition is overcome locally and temporally in brain injury and repair.
Nonequilibrium spin transport on Au(111) surfaces
Creators: name: Liu, Ming-Hao
name: Chen, Son-Hsien
name: Chang, Ching-Ray
Publisher: name: Universität Regensburg
Year: 2008
Subjects: subject: 530 Physik
subject: 73.20.At, 71.70.Ej, 73.23.−b

description: The well-known experimentally observed sp-derived Au(111) Shockley surface states with Rashba spin splitting are perfectly fit by an effective tight-binding model, considering a two-dimensional hexagonal lattice with pz orbital and nearest-neighbor hopping only. The extracted realistic band parameters are then imported to perform the Landauer-Keldysh formalism to calculate nonequilibrium spin transport in a two-terminal setup sandwiching a Au(111) surface channel. Obtained results show strong spin density on the Au(111) surface and demonstrate (i) intrinsic spin-Hall effect, (ii) current-induced spin polarization, and (iii) Rashba spin precession, all of which have been experimentally observed in semiconductor heterostructures but not in metallic surface states. We therefore urge experiments in the latter for these spin phenomena.
Role redefinition as autonomy support : a narrative inquiry
Creators: name: Wisniewski, Tierney
Publisher: name: University of British Columbia
Year: 2017

description: Self-determination theory (SDT) is a well-established theory of motivation that posits that we grow optimally to the degree to which our contexts afford us autonomy support, the collective term for the ways in which others afford us opportunities to satisfy our basic psychological needs for autonomy, relatedness, and competence. Although Ryan and Niemiec (2009) suggest that self-determination theory can be “critical and liberating,” I trouble their assertion, making use of literature on student voice, student-faculty learning partnerships, and radical collegiality, and propose that redefining the student role is an essential form of autonomy support if we wish to follow through on SDT’s liberating possibilities. To that end, I undertook a narrative inquiry into five students’ experiences of transformation through role redefinition in a set of non-traditional university courses. Participants described their experiences and relationships with peers and instructors before, during, and after this set of courses. A thematic analysis revealed that students experienced their post-secondary courses as largely controlling, with concomitant negative effects on their engagement and well-being, while they experienced these non-traditional courses as highly autonomy-supportive, with concomitant positive effects. Analysis also revealed that students underwent two transformative processes: an incremental process of integration and a more epochal process of role redefinition. This latter process in particular was fostered through persistent messages that students’ educations belonged to them, through de-emphasis on the instructor-student hierarchy, and through being supported through their struggles with transformation. Once students redefined their roles, they took more responsibility for their peers’ well-being, offered them autonomy support, and engaged more agentically in other courses by expressing themselves more, taking more risks, and even standing up to and defying miseducative instructors on their own and their peers’ behalves. They came to perceive themselves as agents of change not only in their institutions, but also in other arenas, following through on the critical and liberating potential of SDT that Ryan and Niemiec had envisioned. This study has broad implications for how educators engage with students and how our institutions are structured, as well as how SDT research is conducted, if we wish to capitalize on this potential.
Cell-type Specific Protoporphyrin IX Metabolism in Human Bladder Cancer in vitro
Creators: name: Krieg, Rene C.
name: Fickweiler, Sonja
name: Wolfbeis, Otto S.
name: Knuechel, Ruth
Publisher: name: Universität Regensburg
Year: 2000
Subjects: subject: 540 Chemie

description: 5-Aminolevulinic acid (ALA)–supported fluorescence endoscopy of the urinary bladder results in a detection rate of bladder cancer superior to that of white light endoscopy. The different accumulation of the metabolite protoporphyrin IX (PPIX) in tumor cells after ALA instillation is poorly understood; however, it is crucial to optimize diagnosis and potential phototherapy. For systematic analysis of cell-type specific PPIX accumulation and metabolism two human bladder carcinoma cell lines (RT4 and J82), a normal urothelial cell line (UROtsa), and a fibroblast cell line (N1) were chosen, and grown in two different growth states to model important tissue components of the urinary bladder, i.e. tumor, normal epithelium and stroma. To quantitate PPIX content, fluorescence intensities measured by flow cytometry were matched with cellular PPIX extraction values, and related to relative ferrochelatase activity, cellular iron content, number of transferrin receptors per cell and porphobilinogen deaminase (PBGD) activity. For in vitro experiments, the initial correlation of relative flow cytometric and spectrometric measurements of PPIX provides a calibration curve for consequent flow cytometric PPIX quantification. Lower fluorescence of normal cells could be explained by significant differences of ferrochelatase activity and iron content in comparison to tumor cells. However, the content of iron was not related to transferrin receptor content. PBGD activity seemed to play a minor role for the differential accumulation of PPIX in urothelial cells. In conclusion, the in vitro culture of urothelial cells and fibroblasts indicates that the most important metabolic step for PPIX accumulation in the urinary bladder is the transition from PPIX to heme. Further investigation of PPIX metabolism does support the validation of photodynamic diagnosis, and might also lead the way to a highly specific tumor related molecule.
Optical sensor for seawater salinity
Creators: name: Huber, Christian
name: Klimant, Ingo
name: Krause, Christian
name: Werner, Tobias
name: Mayr, Torsten
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 2000
Subjects: subject: 540 Chemie

description: An optical sensor for the measurement of salinity in seawater has been developed. It is based on a chloride-quenchable fluorescent probe (lucigenin) immobilized on a Nafion film. Two approaches for measuring salinity via chloride concentration are presented. In the first, a change in salinity corresponds to a change in the fluorescence intensity of lucigenin. In the second, the fluorescence intensity information is converted into a phase angle information by adding an inert phosphorescent reference luminophore (a ruthenium complex entrapped in poly(acrylonitrile) beads). Under these conditions, the chloride-dependent fluorescence intensity of lucigenin can be converted into a chloride-dependent fluorescence phase shift which serves as the analytical information. This scheme is referred to as dual lifetime referencing (DLR). The sensor was used to determine the salinity in seawater and brackish water of the North Sea.
Downcast Eyes: Selective Blindness, Disability Disavowal and the Spectre of Fascist Masculinity in the Commedia all'italiana
Creators: name: Hill, Sarah
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: classificationCode: 4705
subject: Literary studies
classificationCode: 4703
subject: Language studies

description: Cinema traditionally casts characters with disabilities or visible physical differences as signifiers of social and moral alterity to aspirational models of individual and national identity, as seen in a wide range of films made in Italy in the decades following the fall of Fascism and the end of World War II. Yet the presence of anti-normative bodies on screen can also help expose dominant narratives that paper over difficult memories of a painful collective past. This is not only true for films that specifically address Italy’s Fascist past but also for commedia all’italiana films focused on contemporary narratives of economic progress and social mobility. Examining a number of these films, this article argues that they employ the reality or threat of disability or difference to embody a troubled post-Fascist masculinity that is itself a representation of traumatic legacies.
Keywords: historical memory of Fascism, Italian cinema, disability, masculinity, Commedia all’italiana.
A New Lorentz-Violating Model of Neutrino Oscillations
Creators: name: Labe, Kevin
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A new model for neutrino oscillations is introduced, in which mass-like behavior is seen at high energies, but various behavior can be predicted at low energies. The model employs no neutrino masses, but instead relies on the Lorentz-violating parameters a and c. Oscillations into antineutrinos and sterile neutrinos are also considered.
description: 4 pages. Presented at the Fifth Meeting on CPT and Lorentz Violation, Bloomington, Indiana, June 28 - July 2, 2010
Fluorescent Beads Coated with Polyaniline: A Novel Nanomaterial for Optical Sensing of pH
Creators: name: Pringsheim, Erika
name: Zimin, D.
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 2001
Subjects: subject: Flow cytometry;Latexes, polyaniline coated;Microbeads;Microscopy, atomic force microscopy;Sensors, optical, beads,pH dependent;Spectroscopy, fluorescence spectroscopy
subject: 540 Chemie

description: A novel optical pH sensor for the physiological rangehas been developed by these authors. The fluorescence emitted (in a pH-independent manner) by dye-doped polymer nanobeads is modulated by a thin conductive polymer coating (see Figure), whose visible-light absorption strongly varies with pH at values around seven.
title: Equity, Insider Trading, & Restatements
Creators: name: Larcker, David F.
name: Tayan, Brian
Publisher: name: Corporate Governance Research Initiative
Year: 2017

description: This Research Spotlight provides a summary of the academic literature on the impact of equity ownership on firm performance and agency problems: The relation between equity ownership and performance, yhe relation between equity ownership and future financial restatements, the impact of clawback policies on future restatements, the relation between equity ownership and insider trading, and the impact of insider trading policies on trading abuses. This Research Spotlight expands upon issues introduced in the Quick Guide “Equity Ownership.”