cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Head boundary conditions in pedestrian crashes with passenger cars: six-degrees-of-freedom post-mortem human subject responses
Creators: name: Paas, Ruth
name: Masson, Catherine
name: Davidsson, Johan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Pharmacology
Neuroscience
Medicine
Engineering

description: In pedestrian–vehicle crashes, head injuries cause death and long-term disability. Thus, understanding the head kinematics is vital. Head rotation data are scarce, and the influence of individual anthropometry, upper body and arm kinematics on head kinematics is poorly understood. This paper investigates the influence of anthropometry, upper body and arm kinematics on head linear and angular kinematics, providing novel six-degrees-of-freedom data from pedestrian–vehicle-crash experiments. Five similarly positioned subjects were struck by a mid-size sedan at 40 km/h. Three-dimensional translation and three-dimensional rotation of the head, spine and shoulders were compared. Head kinematics differed considerably among the subjects. Variations in anthropometry changed pelvic sliding towards the windshield. Arm responses altered head impact velocity and head rotation. The results have implications for future experiments, evaluation of human models and the design of pedestrian safety systems. Head injury risk can be moderated by reducing head rotation before head impact, and by reducing pelvic sliding.
title: Col Repollo :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2023

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
Chemical composition and antibacterial activity of essential oil of Nepeta graciliflora Benth. (Lamiaceae)
Creators: name: Sharma, Pankaj
name: G.C. Shah
name: Sharma, Rabia
name: Dhyani, Praveen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The chemical composition of the essential oil obtained from aerial parts of Nepeta graciliflora was analysed, for the first time, by GC–FID and GC–MS. A total of 27 compounds were identified, constituting over 91.44% of oil composition. The oil was strongly characterised by sesquiterpenes (86.72%), with β-sesquiphellandrene (28.75%), caryophyllene oxide (12.15%), α-bisabolol (8.97%), α-bergamotene (8.51%), β-bisabolene (6.33%) and β-Caryophyllene (5.34%) as the main constituents. The in vitro activity of the essential oil was determined against four micro-organisms in comparison with chloramphenicol by the agar well diffusion and broth dilution method. The oil exhibited good activity against all tested organisms.
Rainfall modeling using Artificial Neural Network for a mountainous region in west Iran
Creators: name: Mekanik, Fatemeh
name: Lee, T. S.
name: Imteaz, Monzur
Publisher: name: Swinburne
Year: 2024

description: One of the major problems in water resources management is rainfall forecasting. With the effect of rainfall on water resources as a foregone conclusion, more accurate prediction of rainfall would enable more efficient utilization of water resources and power generation. Countries depending on agro-based economy could benefit tremendously from accurate long-term rainfall predictions. Thus, long-range forecasts require indefatigable effort and long planning using different methods. This study gives attention to long-term rainfall modelling since a long-term forecasting could provide better information for optimal management of a resource that is to be used over a substantial period of time. The aim of the study is also to investigate the capability of non-linear techniques on long-term rainfall forecasting. One of the non-linear techniques being widely used is the Artificial Neural Networks (ANN) approach which has the ability of mapping between input and output patterns without a priori knowledge of the system being modelled. The main aim of the study is to develop a model which is capable of forecasting 12 months rainfall in advance. A feedforward Artificial Neural Network (ANN) rainfall model was developed to investigate its potentials in forecasting rainfall. The study area is the west mountainous region of Iran and the model was developed for a synoptic station in this region. Three separate ANN models with three different input data sets were trained. The first model investigated the effect of the number of lags on the performance of the ANN. The number of lags varied from 1-12 previous months. The second model investigated the effect of adding monthly average to the inputs, and the third model considered seasonal average as an extra input data in addition to the ones in the second model. The effect of the number of hidden neurons on ANN modeling was also examined. The models were trained based on the Levenberg-Marquardt algorithm with tansigmoid activation function for the hidden layer and purelin activation function for the output layer. Monthly rainfall data of 1977-2002 were used for training the models. The models were tested with monthly rainfall data of 2003. It was proven that the larger lags outperform the lower ones in ANN modeling. Also, adding the extra monthly and seasonal average to the input data set leads to better model performance. The number of hidden neurons was varied from 1-30. It was demonstrated that input neurons have more effect on performance criteria than the hidden neurons. Simulation results for the independent testing data series showed that the model can perform well in simulating one year monthly rainfall in advance.
Changes in the population distribution in Poland in the years 1946–2012
Creators: name: Paweł Cebrykow
name: Mirosław Krukowski
name: Małgorzata Flaga
name: Kałamucki, Krzysztof
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Computational Biology

description: This paper presents a method of development concerning maps of changes in the population distribution in Poland after the Second World War (1946–2012). The phenomenon is presented by means of isolinear maps based of the population density index. The resulting maps illustrate the population distribution in intervals of approximately 10 years. Moreover, the changes themselves are presented in balance maps corresponding to periods between the selected dates. The maps highlight spatial changes in the population distribution in Poland. The key task was to develop a method of preparing maps providing an objective and comparable image of the population distribution. This was obtained by means of the isoline method with the application of a multipoint representation of administrative units (basic fields) differing in terms of area and shape. Comparability was also achieved through the appropriate preparation of standardised map legends (colour scales and isoline interval). The maps were prepared in scales of 1:8,000,000 (state maps) and 1:400,000 (change/balance maps).
Lasing with well-defined cavity modes in dye-infiltrated silica inverse opals
Creators: name: Nishijima, Y.
name: Ueno, K.
name: Juodkazis, Saulius
name: Mizeikis, V.
name: Fujiwara, Hideki
name: Sasaki, Keiji
name: Misawa, Hiroaki
Publisher: name: Swinburne
Year: 2024

description: Lasing in dye solution-embedded inverse silica opal structures was investigated. The opal films were prepared by sedimentation of polystyrene microspheres on a cover glass. The polystyrene structures were inverted using sol-gel infiltration of silica and subsequent removal of polystyrene. Photoluminescence of rhodamine (rhodamine B, 6G and sulfo-rhodamine 101) dye solutions embedded into the inverse silica opal structures exhibited clear signatures of the lasing via a distributed feedback (DFB) and gain modulation. The refractive index contrast between the dye and the inverse opal was small enough (~ 0.03%) for the formation of refractive index coupling between the lasing modes. The lasing spectrum exhibited a highly regular periodic structure of modal peaks, rather than the chaotic superposition of peaks reported in previous studies. Lasing modes having a spectral width of about 0.25 nm and a free spectral range of about 0.75 nm appeared at the position of the maximum gain (the maximum fluorescence of the dye).
Fight Club: A Journey Through Duality, Truth, and Self-Acceptance
Creators: name: Toledo, Michel
Publisher: name: Zenodo
Year: 2011

description: This article reflects on "Fight Club" from a psychological and philosophical perspective, addressing the protagonist Jack's duality and his relationship with violence, truth, and self-acceptance. Through his interaction with characters like Tyler and Marla, the film critiques materialism and emotional detachment while exploring the protagonist's transformation from schizophrenia to the understanding of a new reality. This analysis suggests that the film transcends anarchism and system destruction, proposing the need to embrace both pain and duality to achieve personal balance.
Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition.
Creators: name: Ling, Stephanie
name: Dexter, Alex
name: Race, Alan M
name: Sharma, Shreya
name: Hamm, Gregory
name: Polanska, Urszula M
name: UK, Rosetta Consortium Cancer Research
name: Marshall, John F
name: Takats, Zoltan
name: Brindle, Kevin
name: Yuneva, Mariia O
name: Poulogiannis, George
name: Campbell, Andrew D
name: Sansom, Owen J
name: Goodwin, Richard JA
name: Bunch, Josephine
name: Barry, Simon T
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Signalling & Oncogenes
subject: Signalling & Oncogenes
classificationCode: Metabolism
subject: Metabolism
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology
classificationCode: Genome Integrity & Repair
subject: Genome Integrity & Repair
classificationCode: Human Biology & Physiology
subject: Human Biology & Physiology
classificationCode: Model organisms
subject: Model organisms

description: The PI3K-mTOR-AKT pathway regulates tumour proliferation, gene expression and metabolism, but pathway inhibition induces heterogeneous feedback reactivation, limiting anti-tumour responses. Measuring heterogeneity of pathway inhibition in tissues using protein biomarker phosphorylation or location is challenging. An integrated multi-modal imaging workflow was developed to assess the heterogeneity of AZD2014 (mTORC1/2 inhibitor) response in a PTEN-null renal cancer model. Spatial responses of metabolite biomarkers were analysed by mass spectrometry imaging (MSI). Control and treated tumours were classified according to metabolite-defined regions enriched in control versus AZD2014-treated tumours, respectively. Noticeably, AZD2014-treated tumours retained regions similar to regions dominant in untreated tumours. Imaging mass cytometry analysis of protein biomarkers in 'control-like' regions following AZD2014 treatment showed reduced phospho-S6, indicating suppression, but retained high expression of the glucose transporter GLUT1. Increasing PI3K-AKT inhibition by combining with AZD8186 (PI3Kβ inhibitor) further decreased the control-like metabolic signature, showing PI3K-dependent resistance. This demonstrates that MSI-based workflows yield novel insights into the pharmacodynamic effects of mTORC1/2 inhibition in tumours, which classical biomarkers do not resolve. Coupling these workflows with spatial-omics approaches can deliver greater insights into heterogeneity of treatment response.
Crystal structures of chloro-, bromo-, and nitro-substituted chromium(III) acetylacetonates
Creators: name: Svistunova, Irina V.
name: Pushilin, Michail A.
name: Gelfand, Natalia A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The molecular and crystal structures of chlorine-, bromine-, and nitro-substituted chromium(III) acetylacetonate are determined. Connecting the substituent to the central atom does not change bond lengths and valence angles in metal chelate rings. Studied chromium complexes are characterized by greater intermolecular interactions compared with analogous metal acetylacetonates. In some cases, intermolecular interactions increase the bend of chelate rings along the O⋯O line. Substituents do not interact with chromium ions of neighboring molecules because metal is blocked by three ligands.
Generation of coherent radiation in the water window
Creators: name: Dao, Lap
name: Vu, H. L.
name: Dinh, Khuong
name: Gaffney, N. S.
name: Balaur, E.
name: Hannaford, Peter
name: Smith, Trevor A.
Publisher: name: Swinburne
Year: 2024

description: The phase-matched harmonic radiation down to the water window region (~ 4.4 nm) is obtained and exhibits a good beam profile and high spatial coherence using a 1 kHz infrared pulses at 1400 nm.
Corporate sustainability reporting by pharmaceutical companies: Is it what it seems to be?
Creators: name: Azim, Mohammad
name: Azam, Saiful
Publisher: name: Swinburne
Year: 2024

description: A well-functioning pharmaceutical industry can contribute directly to social wellbeing. Corporate sustainability is an important precondition for the further development and growth of the industry. In this research multi methods are used to provide a complete, holistic and contextual portrait of the level of CSR by pharmaceutical companies in a developing country - Bangladesh. Firstly, we used content analysis to investigate corporate social reporting by listed pharmaceutical companies. Secondly, we conducted surveys to document management responses. Thirdly, we sought stakeholders' views on the extent to which they believe CSR is being implemented in the industry. Analysis of annual reports published in 2009- 2010 shows that only 26.67% of listed pharmaceutical companies made some CSR disclosure. However, more than seventy-five per cent of these disclosures are sweeping qualitative statements without any attempt at quantification. Most managers believe social reporting should strike a balance between meeting stakeholders' reasonable expectations and running a successful business. The majority of stakeholders appear to favour mandatory requirements for CSR disclosure.
Local self-government structure in the EU member states in 2011
Creators: name: Klobučník, Michal
name: Bačík, Vladimír
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cardiology

description: This paper aims to point out the current size structure of the smallest self-government units in the European Union (EU) countries. Municipal reform is currently an ongoing process which has already taken place in several EU member states and resulted in a differentiated structure of these units. Local self-government units have legitimately elected representatives whose action influences the day-to-day life of local residents. From the perspective of comparative analysis, it is important to understand the size structure of local self-government units which has an enormous impact on the functioning of the self-government and it is a key factor in terms of the amount of funding available in these units. The dynamics of integration and disintegration changes are relatively strong as confirmed by the results of our analysis where in almost every EU member state the number of these units has changed more or less significantly in the last decade (2001–2011). For the sake of better mutual comparison, the final map interpretation (the number of local self-government units in the EU) was drawn up to 2011 when all EU member states conducted a census.
title: Red Clover :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2015

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Influence of redox activation of NAMI-A on affinity to serum proteins: transferrin and albumin
Creators: name: K. Śpiewak
name: G. Stochel
name: M. Brindell
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: Imidazolium trans-tetrachloridodimethylsulfoxideimidazoleruthenate(III), NAMI-A, is a ruthenium drug exhibiting unique properties under clinical studies such as ability to inhibit the process of metastases without exerting tumor toxicity. Its place of action is concentrated at the extracellular level, therefore, the transformation and fate of this drug upon injection is of great importance. This study focuses on evaluation of the reducing potency of blood stream on interaction with two serum proteins: albumin and transferrin. It was investigated by applying various simplified serum models preserving physiological concentration of proteins and the amount of Ru complex as found in patients. It was shown that ruthenation of albumin is slightly increased while transferrin decreased upon addition of reductant in blood stream (ascorbate, glutathione, and cysteine) at physiological concentration. Interestingly, in serum models comprising low-molecular-mass components the amount of the reductant in the solution had a pronounced effect on the Ru content, in particular in transferrin. Supplementation of serum models with glutathione at concentration enough for complete reduction of NAMI-A selectively enhanced the binding of Ru complex to transferrin while ruthenation of albumin was almost unchanged. Spectrofluorimetric studies revealed that reduction has a marginal effect on binding affinity, therefore, both Ru(III) and (II) derivatives equally can compete for binding to transferrin.
QA Software Testing Guidelines for Open Preprint Systems (OPS)
Creators: name: Carmel, Gonzalvez
Publisher: name: Indian Open Preprint System
Year: 2024

description: These guidelines provide a structured approach to QA software testing for Open Preprint Systems (OPS), ensuring the delivery of a high-quality, reliable system. The guidelines align with the ISO/IEC/IEEE 29119-1:2022 standard, focusing on standardized concepts and definitions to ensure a consistent understanding of software testing practices.
Providing timely assignment feedback to large online student cohorts
Creators: name: Fleckhammer, Lorraine
name: Wise, Lisa
Publisher: name: Swinburne
Year: 2024

description: The strong market demand for psychology to be taught online has seen a rapid growth in enrolments in psychology units delivered by Open Universities Australia. Students studying in the online environment have expectations of a fast turnaround of their assignments along with an individual critique of their work. Such expectations can prove difficult to fulfill and the challenge will only be exacerbated as student numbers increase. This paper outlines four different models of assignment marking, adopted in an online Introductory Psychology unit with a high student enrolment and a correspondingly large teaching team. The first model of assignment marking focused on transitioning experienced on-campus teaching staff to the online environment. Subsequent models aimed to reduce inefficiencies in the assignment marking process, without a reduction in pedagogical effectiveness. The current model (Model 4) no longer includes the time-consuming process of annotating student's assignments with embedded comments. This change, while originally motivated purely by efficiency and budgetary constraints, has proved to be pedagogically effective. The faster return of grades accompanied by a brief individual comment on the overall quality of the work (rather than more extensive comments embedded as annotations within the assignment document) meets student expectations with respect to feedback, and when used in conjunction with more focused 'feedforward' through use of tutor teams and stronger tutor-student relationships, appears to provide a more effective teaching and learning outcome.
Crystal structures of chloro-, bromo- and nitrosubstituted chromium(III) acetylacetonates
Creators: name: Svistunova, Irina V.
name: Pushilin, Michail A.
name: Gelfand, Natalia A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: :The molecular and crystal structures of chlorine-, bromine and nitro-substituted chromium(III) acetylacetonate are determined. Connecting the substituent to the central atom does not change bond lengths and valence angles in metal chelate rings. Studied chromium complexes are characterized by greater intermolecular interactions compared with analogous metal acetylacetonates. In some cases, intermolecular interactions increase the bend of chelate rings along the O···O line. Substituents do not interact with chromium ions of neighboring molecules, because metal is blocked by three ligands.
Using Natural Archives to Reconstruct Environmental Changes Caused by Human Activities
Creators: name: Gallant, Lauren Rachel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: natural archives
Arctic
lakes
sediments
bats
guano
isotopes
metals
sterols
stanols

description: The objective of this thesis was to develop new approaches and perspectives in resolving historical information from natural archives. Paleolimnology, the study of past aquatic environments using lake sediment cores, has greatly advanced our understanding of previous environments. This thesis intended to expand the range of historical information that may be used in paleolimnology and for historical reconstructions. Here I used pond sediments and a bat guano deposit as natural archives that recorded a history of events that I interpreted using a combination of chemical and biological measurements. In particular, I applied sterols and stanols as novel approaches for interpreting historical information in natural archives. First, I examined the chemical and biological composition of lake sediments to track the human occupation of Dorset and Thule people in Canada’s High Arctic. As predicted, sterols, stanols, cadmium, copper, and zinc increased in sediments deposited during known periods of human occupation owing to nutrient addition, whereas these increases were absent in reference sites. These methods were further corroborated in a study of 20th century human occupation at Resolute Bay by examining similar constituents in waterbodies that received wastewater discharge. Second, I used δ15N and δ13C to track the agricultural history of Jamaica using a 4,300-year-old bat guano deposit. I then used C/N, δ13C, and sterol and stanol ratios to detect two periods of increased frugivory relative to insectivory-based foraging. Metals normalized to titanium increased during the Industrial Revolution and 206Pb/207Pb values tracked the introduction and subsequent ban of leaded gasoline. I also examined the same chemical constituents in fresh bat guano from frugivorous, insectivorous, and sanguinivorous bats. C/N values decreased and cholestanol, cholesterol, and cholesterol/(cholesterol+sitosterol) values increased in bat guano according to trophic level. This thesis demonstrated the strength of examining several independent lines of evidence to reconstruct historical activities in both High Arctic waterbody sediments and a bat guano deposit. I showed that human activities were traceable within natural archives over several thousand years thus demonstrating that the multi-proxy approach is a powerful tool that can conduct a broad range of analyses in various natural archives.
Floral Categorization in Bumblebees
Creators: name: Xu, Vicki
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Bumblebee
Categorization
flower
comparative cognition
behaviour
foraging
animal behaviour
insect cognition
bee
picture
object
discrimination
generalization
perception

description: In nature, pollinators must navigate fields of resources presenting a variety of features, differing in shape, size, colour, etc. Foraging on a flower by flower basis is slow and maladaptive. Instead foragers must be able to differentiate between rewarding and unrewarding floral species while also generalizing learned information between flowers of the same species. The ability to categorize stimuli occurs on several levels of abstraction, laid out by Herrnstein (1990). In order to categorize objects, animals must first be able differentiate between them without memorizing each stimulus separately. Consequently, objects can be grouped by physical characteristics through perceptual categorization, or, on a more abstract scale, by the function they serve to the animal. This thesis explores the bees’ ability to categorize flowers, following the levels of categorization to answer two questions: Can bees form categories? And how abstract can their categorization become? There has been limited investigation previously in categorization in bees, and no research done on invertebrates addresses categorization beyond physical features. The bees’ ability to form categories was evaluated with four experiments of preference: 1) similar-but-different judgements; 2) perceptual categorization; 3) simple and mediated generalization; and 4) functional relevance. Results show firstly that bees can generalize characteristics within flower species, but also differentiate individual flowers. Secondly, bees can form perceptual categories, and while they rely on physical floral features for categorization, bees also demonstrated preliminary abilities for functional generalization as well. These results provide an explanation to natural foraging techniques adopted by the bees. The adaptive nature of categorization allows foragers to find resources more efficiently and better prepare in changing environments.
Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease.
Creators: name: Mercado, Nicolas
name: Colley, Thomas
name: Baker, Jonathan R
name: Chaitanya Vuppussetty
name: Kono, Yuta
name: Clarke, Colin
name: Tooze, Sharon
name: Johansen, Terje
name: Barnes, Peter J
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Model organisms
Biochemistry & Proteomics
Imaging
Signalling & Oncogenes
Cell Biology
Chemical Biology & High Throughput

description: Bicaudal D1 (BICD1), an adaptor for the dynein-dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress-induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective autophagy can be caused by mutations in the dynein and dynactin motor complex suggesting a possible link between BICD1 and defective autophagy in COPD. BICD1 levels were measured in peripheral lung tissue from COPD patients together with markers of autophagy and found to be increased in COPD together with autophagosomes, p62 and p62 oligomers. In vitro exposure of bronchial epithelial cells to cigarette smoke extracts (CSEs) revealed that high concentrations of CSE induced defective autophagosome maturation with accumulation of BICD1, p62 and ubiquitin-associated p62 oligomers. This was confirmed in vivo using CS-exposed mice. Furthermore, we identified that formation of CS-induced p62 oligomers required an interaction with Keap1. Overexpression and ablation of BICD1 confirmed that increased BICD1 negatively regulates autophagosome maturation inducing accumulation of p62 and p62 oligomers and that it can be reversed by cardiac glycosides. We conclude that defective autophagosome maturation in COPD is caused by oxidative stress-mediated BICD1 accumulation.
Geology of the Scalaro valley – Sesia Zone (Italian Western Alps)
Creators: name: Regis, Daniele
name: Venturini, Guido
name: Engi, Martin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology

description: In the Sesia Zone (Italian Western Alps), slivers of continental crust characterised by an Alpine high-pressure imprint are intermingled with abundant mafic rocks and Mesozoic metasediments. An extensive study of the central Sesia Zone was undertaken to identify and reconstruct the lithological setting of the mono-cyclic sediments of the Scalaro Unit. A new geological map (1:5000) and schematic cross sections across the Scalaro Unit and the adjoining Eclogitic Micaschist Complex are presented here. In order to delimit the size and shape of the mono-metamorphic unit and understand its internal geometry with respect to the poly-metamorphic basement, an integrated approach was used. Linking observations and data across a range of scales, from kilometres in the field down to petrological and chronological data obtained at micrometre scale, we define for the first time the real size and internal geometry of the Scalaro Unit, as well as its large-scale structural context.
A perceptual training module for pilot instrument scans
Creators: name: McLean, Greg
name: Wise, Lisa
name: Williams, Benedict
Publisher: name: Swinburne
Year: 2024

description: The current generation of young people have grown up with digital technologies and this has led to widespread consideration of how to use these technologies for education and training. We are interested in the potential for developing game-like training modules for deployment on personal digital devices to allow trainee pilots to practise information extraction skills for a variety of different contexts. The current study is based on an instrument scanning perceptual training module reported by Kellman and Kaiser (1994). While we expect that novices will be able to easily learn the instrument scanning tasks, it is important to ascertain whether their performance reflects an increased understanding of the flying situation, or just a correct choice learned implicitly within the context of the specific experimental tasks. If the latter, the possibility of negative transfer of gaming strategies to real world performance requires further examination.
Bonding Behaviour of Steel Fibres in UHPFRC Based on Alkali-Activated Slag
Creators: name: Wetzel, Alexander
name: Göbel, Daniela
name: Schleiting, Maximilian
name: Wiemer, Niels
name: Middendorf, Bernhard
Publisher: name: Universität Kassel
Year: 2022
Subjects: subject: ultra-high-performance concrete
subject: fibre pullout
subject: silica fume
subject: potassium waterglass
subject: fibre reinforcement
subject: 660
subject: Ultrahochfester Beton
subject: Stahlfaser
subject: Wasserglas
subject: Kalisalze
subject: Faserverstärkung
subject: Verbundverhalten

description: Gefördert durch den Publikationsfonds der Universität Kassel
Mapping cost distance using air traffic data
Creators: name: Dudás, Gábor
name: Boros, Lajos
name: Pál, Viktor
name: Pernyész, Péter
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Plant Biology

description: Recent trends in transport and communication infrastructures have had a profound impact on the spatial organization of the world city network, which have long been of interest to geographers. Considering the former issue, our study is based on previous works on air transport geography and world city network studies. We introduce a new method to map the gap between geographical distance and cost distance by using air traffic data. In this paper, we created an international database for a large number of world cities and developed a way to map cost distance using conventional and Geographic Information System-based mapping techniques. The main result of this work is a set of maps showing the cost distances of world cities, which can be used as a significant source of information by world city network analysis.
An expressway from agent-oriented models to prototypes
Creators: name: Taveter, Kuldar
name: Sterling, Leon
Publisher: name: Swinburne
Year: 2024

description: Agent-oriented software engineering can be viewed as applying software engineering principles to agent-oriented development or applying agent-oriented principles to software engineering. In this paper, we are more concerned with the second view. We describe how prototype systems can be efficiently created from agent-oriented domain and design models. We propose a conceptual space that accommodates model transformations described by the Model-Driven Architecture. We explain agent-oriented domain models and platform-independent design models and show how the first can be mapped to the latter. We demonstrate how design models can be turned into the implementation of an agent-based prototype on a specific platform. The approach has potential for accelerating the process of rapid prototyping.
Supporting evolving multi-agent systems with a system evolution directory
Creators: name: Lu, Bin
name: Sterling, Leon
name: Taveter, Kuldar
Publisher: name: Swinburne
Year: 2024

description: In order to describe how a structure - System Evolution Directory (SED), can be used to facilitate the evolution of multi-agent systems, we first introduce a case study on citation finding. We use this case study to explain the components within a SED and the process to build a SED. A unified and simple model directory is used to describe the life cycle of a system and a goal model to describe the meaning among system artefacts. Developers can not only get all necessary information ranging from high level system requirements to low level source code from the model, but also can understand semantic connections between system artefacts. Different versions of a system can be recorded easily in the structure. We believe the structure has potential for further speeding up and automating the process of system evolution. All in all, the structure complements current agent-oriented methodologies.
Influence of redox activation of NAMI-A on affinity to serum proteins: Transferrin and albumin
Creators: name: K. Śpiewak
name: G. Stochel
name: M. Brindell
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: Imidazolium trans-tetrachloridodimethylsulfoxideimidazoleruthenate(III), NAMI-A, is a ruthenium drug exhibiting unique properties under clinical studies such as ability to inhibit the process of metastases without exerting tumor toxicity. Its place of action is concentrated at the extracellular level therefore the transformation and fate of this drug upon injection is of great importance. This study focuses on evaluation of the reducing potency of blood stream on interaction with two serum proteins: albumin and transferrin. It was investigated by applying various simplified serum models preserving physiological concentration of proteins and the amount of Ru complex as found in patients. It was shown that ruthenation of albumin is slightly increased while transferrin decreased upon addition of reductant in blood stream (ascorbate, glutathione and cysteine) at physiological concentration. Interestingly, in serum models comprising low-molecular-mass components the amount of the reductant in the solution had a pronounced effect on the Ru content, in particular in transferrin. Supplementation of serum models with glutathione at concentration enough for complete reduction of NAMI-A selectively enhanced the binding of Ru complex to transferrin while ruthenation of albumin was almost unchanged. Spectrofluorimetric studies revealed that reduction has a marginal effect on binding affinity, therefore both Ru(III) and (II) derivatives equally can compete for binding to transferrin.
title: Trébol Rojo :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2021

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
Analysis and design of multi agent knowledge development process
Creators: name: Shiang, Cheah Wai
name: Sterling, Leon
Publisher: name: Swinburne
Year: 2024

description: Within multi agent systems (MAS), knowledge plays an important role in agent communication, reasoning and supporting interoperability. It is often considered as an ontology which contains explicit domain knowledge to be used by agents. Although there are many ontology development or engineering methodologies, current efforts to incorporate knowledge into MAS are too focused on computational aspects or ad hoc. Working at the computational model is too low level, and many processes are left Implicit to the developer. This paper focuses on engineering the agent knowledge development process. A set of activities is proposed to externalize processes involved in managing agent domain knowledge, preferring software engineering approaches to ad hoc processes. The activities are classified into analysis and design steps together forming a development model suite (e.g. user model, motivation model, task model and design model). With guidance, we have successfully developed agents' knowledge based on a real life application in finding a potential advisor for a graduate student. Finally, it enables the agent developer to use, reuse and maintain the agent knowledge.
The role of tutors in facilitating online student engagement
Creators: name: Fleckhammer, Lorraine
name: Wise, Lisa
Publisher: name: Swinburne
Year: 2024

description: This paper discusses the role of the tutor in developing an online learning community to promote student engagement for large online cohorts. Information overload on the discussion boards was addressed by separating students into streams of 150 – 200 students promoting greater student and staff engagement. A new feedback strategy was introduced to streamline the assignment-marking process and this feedback process has proved to be more socially engaging than traditional feedback via comments embedded within student assignments. The new feedback model involves commentary on assignments, which becomes a 'conversation' with the student rather than a series of comments embedded within assignments. In addition, easier access to comments allows greater opportunity for moderation of marks by tutoring teams and for 'feedforward' for subsequent assignments. The importance of the level of engagement and commitment to teaching of the tutoring staff has been made apparent by the serendipitous changes to the tutoring role.
Control of tissue morphogenesis by the HOX gene Ultrabithorax.
Creators: name: Maria-Del-Carmen Diaz-De-La-Loza
name: Loker, Ryan
name: Mann, Richard S
name: Thompson, Barry J
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Model organisms
Tumour Biology
Signalling & Oncogenes
Developmental Biology
Chemical Biology & High Throughput
Computational & Systems Biology

description: Mutations in the Ultrabithorax (Ubx) gene cause homeotic transformation of the normally two-winged Drosophila into a four-winged mutant fly. Ubx encodes a HOX family transcription factor that specifies segment identity, including transformation of the second set of wings into rudimentary halteres. Ubx is known to control the expression of many genes that regulate tissue growth and patterning, but how it regulates tissue morphogenesis to reshape the wing into a haltere is still unclear. Here, we show that Ubx acts by repressing the expression of two genes in the haltere, Stubble and Notopleural, both of which encode transmembrane proteases that remodel the apical extracellular matrix to promote wing morphogenesis. In addition, Ubx induces expression of the Tissue inhibitor of metalloproteases in the haltere, which prevents the basal extracellular matrix remodelling necessary for wing morphogenesis. Our results provide a long-awaited explanation for how Ubx controls morphogenetic transformation.
Activities in emergency management: Evidence from case study
Creators: name: Ahmed, Ashir
name: Sugianto, Lyfie
Publisher: name: Swinburne
Year: 2024

description: This paper presents an activity based model for the adoption of technology in emergency management. Furthermore, multiple case study has been employed as a research method to validate the proposed conceptual model. The empirical findings from multiple case studies are also reported in this paper. It is hoped that our research findings will better inform researchers in the field and facilitate organizations in adopting technology for emergency management.
title: A multitasking perspective on sequence representations and multimedia learning
Creators: name: Zhao, Fang
Publisher: name: MyCoRe Community
Year: 2024
Subjects: subject: multitasking
subject: representations
subject: sequence learning
subject: prediction
subject: task integration
subject: cognitive capacity
subject: multimedia
subject: 150

description: This habilitation thesis (17 articles) uses multitasking to understand how the mind works. Utilizing basic lab experiments as well as applied research the articles of this thesis examine the interplay of representations and the processes which operate upon them. The basic lab experiments (Articles 1 to 10) revealed that the human cognitive system employs various sources (e.g., fixed serial order) to predict upcoming stimuli and responses. It automatically integrates two tasks into one, which can be the reason for dual-task costs. The applied learning experiments (Articles 11-17) used the assumption that dual-task interference can occur in the human operating system when two tasks compete for the same mental resources (e.g., deterioration in postural control can be due to high cognitive load). Moreover, methodological approaches developed in basic multitasking research can be adopted to study information processing in applied settings. For instance, the switching costs approach was adopted from task switching to examine graph comprehension. It suggests that the human cognitive system can extract information from graphs based on a hierarchical structure with several invariant common schemas and underlying specific schemas. Taking all of this into account, this thesis exemplifies that multitasking can be used as a window into the mind. It extends our knowledge on cognitive structure, flexibility and plasticity of the mind.
Tipping elements of the climate system
Creators: name: Swingedouw, Didier
Publisher: name: Zenodo
Year: 2017

description: Presentation at the workshop on “Tipping Elements in the Climate System, with a Focus on the North Atlantic” organised by Blue-Action on 18-19 September 2017.
description: The Blue-Action project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No 727852.
title: Chou Pommé :
title: Principes directeurs pour la conduite de l’examen de la distinction, de l’homogénéité et de la stabilité.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2023

description: Ces principes directeurs (“principes directeurs d’examen”) visent à approfondir les principes énoncés dans l’introduction générale (document TG/1/3) et dans les documents TGP qui s’y rapportent afin de donner des indications concrètes détaillées pour l’harmonisation de l’examen de la distinction, de l’homogénéité et de la stabilité (DHS) et, en particulier, à identifier des caractères convenant à l’examen DHS et à la production de descriptions variétales harmonisées.
What benefits can be brought forward by adopting RFID in emergency management?
Creators: name: Ahmed, Ashir
name: Sugianto, Lyfie
Publisher: name: Swinburne
Year: 2024

description: This paper addresses the impacts of RFID (radio frequency identification) adoption on the performance of emergency management organizations. The research question queries: What are the impacts of RFID adoption on the performance of emergency management operations? In order to investigate the hypothesized impacts including reduced response time, efficient tagging and tracking, compatibility, reduced labor cost and robustness, multiple case study has been employed as the research method. It is anticipated that the findings of this research will assist the emergency management organizations to better plan the adoption of pertinent technologies such as RFID for emergency operations.
Una vitamina que no es vitamina.
Creators: name: González-Duarte, Ramiro José
Publisher: name: figshare
Year: 2015
Subjects: subject: Physiology
subject: FOS: Biological sciences

description: Un breve artículo de divulgación científica sobre la vitamina D y su papel en la fisiología humana. Fue publicado en la Revista ¿Cómo ves? de la UNAM en mayo del 2013.