cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional implications of Fkrp deficiency
Creators: name: Whitmore, Charlotte
Publisher: name: Imperial College London
Year: 2013

description: Mutations in FKRP (fukutin related protein) are associated with the dystroglycanopathies, a group of neuromuscular conditions with a spectrum of clinical phenotypes. However, as there is currently no method for detecting Fkrp expression, or measuring its activity, the function has not been fully elucidated. Here, the implications of Fkrp deficiency have been evaluated to provide further insight into the role of this protein. In the muscle, brain and eye (three tissues severely affected in dystroglycanopathy patients), it was shown using the FKRPKD mouse, with its global reduction in Fkrp expression of 80%, that basement membrane deposition was perturbed in the muscle fibres of the tongue, the pial basement membrane of the cortex and both ocular basement membranes (Bruch’s and the inner limiting membrane). It was also demonstrated that these basement membrane defects were associated with altered, reduced glyosylation of α-dystroglycan, and that these changes had marked consequences for cortical and retinal lamination. Interestingly, this investigation highlighted an important, previously undescribed, role for glycosylated α-dystroglycan in early brain and retinal development. To investigate the effects of reduced Fkrp expression on muscle, a novel mouse (FKRPMD) was generated, with had restored f Fkrp expression in the central nervous system. This mouse developed a mild dystrophic pathology, associated with defects in basement membrane deposition and altered, reduced glycosylation of α-dystroglycan. LARGE upregulation has been published as a successful short-term therapeutic strategy in other preclinical dystroglycanopathy models, but none with impaired Fkrp expression. Here, it was demonstrated that long-term LARGE upregulation exacerbated dystrophic pathology in the FKRPMD mouse, despite increased α-dystroglycan glycosylation. In combination, this work highlights the critical role of Fkrp for basement membrane deposition in muscle, brain and eye, identifies the downstream consequences for these three organs and highlights that LARGE upregulation as a therapeutic strategy requires further investigation.
Additional file 1: of Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis
Creators: name: Petrusca, Daniela
name: Toscani, Denise
name: Wang, Feng-Ming
name: Park, Cheolkyu
name: Crean, Colin
name: Anderson, Judith
name: Marino, Silvia
name: Mohammad, Khalid
name: Zhou, Dan
name: Silbermann, Rebecca
name: Sun, Quanhong
name: Kurihara, Noriyoshi
name: Galson, Deborah
name: Giuliani, Nicola
name: Roodman, G
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Main characteristics of the US Patients and Normal donors cohort. Table S2. Main characteristics of the Italian patientâ s cohort. Table S3. Sequences of qPCR primers used for amplification of human mRNA. (DOCX 22 kb)
Gamma-Ray Burst Afterglows: Effects of Radiative Corrections and Nonuniformity of the Surrounding Medium
Creators: name: Dai, Z. G.
name: Lu, T.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The afterglow of a gamma-ray burst (GRB) is commonly thought to be due to continuous deceleration of a relativistically expanding fireball in the surrounding medium. Assuming that the expansion of the fireball is adiabatic and that the density of the medium is a power-law function of shock radius, viz., $n_{ext}\propto R^{-k}$, we analytically study the effects of the first-order radiative correction and the nonuniformity of the medium on a GRB afterglow. We first derive a new relation among the observed time, the shock radius and the fireball's Lorentz factor: $t_\oplus=R/4(4-k)γ^2c$, and also derive a new relation among the comoving time, the shock radius and the fireball's Lorentz factor: $t_{co}=2R/(5-k)γc$. We next study the evolution of the fireball by using the analytic solution of Blandford and McKee (1976). The radiation losses may not significantly influence this evolution. We further derive new scaling laws both between the X-ray flux and observed time and between the optical flux and observed time. We use these scaling laws to discuss the afterglows of GRB 970228 and GRB 970616, and find that if the spectral index of the electron distribution is $p=2.5$, implied from the spectra of GRBs, the X-ray afterglow of GRB970616 is well fitted by assuming $k=2$.
description: 17 pages, no figures, Latex file, MNRAS in press
SISMANTILLES
Creators: name: HIRN Alfred
Publisher: name: Sismer
Year: 2001

description: Les objectifs précis sont la cartographie de l'interplaque de subduction dans sa partie potentiellement sismogénique le long de l'Arc des Petites Antilles, du Nord de la Guadeloupe et Antigua jusqu'à la Martinique en passant par la Dominique, contribuant à l'identification et la localisation à l'avance de la zone de rupture maximale de possibles séismes majeurs futurs, et la recherche de signaux transitoires de l'activité sismique. Pour atteindre ces objectifs, cette campagne a mis en oeuvre les méthodes spécifiques pour l'imagerie profonde de sa structure et de son activité sismique.La zone de travail s'est étendue du Sud de la Martinique à 14°30' N, en passant par la Dominique, la Guadeloupe et jusqu'à Antigua a 17° 30' N. Sur 260 km de long, 7 profils longitudinaux espacés d'une vingtaine de kilomètres ont été réalisés, ainsi qu'une douzaine de transects allant jusqu'à 120 km des côtes. Les noeuds de cette grille de profils étaient occupés par  des capteurs-enregistreurs sismiques fond de mer OBS qui sont restés plusieurs mois au fond pour enregistrer les séismes locaux.Pour cartographier la localisation et variation spatiale de cette zone sismogénique potentielle, la géométrie et les paramètres de la grille de profils reflexion-réfraction ont été fixés au préalable grâce aux résultats structuraux issus de la première campagne de reconnaissance SISMANTILLES (2001, N/O NADIR). En plus des études structurales réalisées par sources artificielles, les séismes locaux, enregistrés par le réseau d'OBS qui était dense et étendu, apportent un éclairage des structures qui sont actives.En Janvier, le Navire Océanographique (N/O) Maria S. Merian a déployé un réseau de 60 OBS à l'ouest d'Antigua, de la Guadeloupe, de la Dominique et de la Martinique dans le cadre d'une coopération avec nos collègues allemands de l'IFM-Geomar (Kiel, Allemagne). En Février, le N/O Atalante de l'IFREMER a déployé 20 OBS complémentaires et réalisé une vaste opération d'imagerie sismique qui permettra d'obtenir des images détaillées des déformations associées au plongement de la plaque Atlantique sous les Caraïbes.Le réseau de 80 OBS a enregistré pendant près de 3 mois la microsismicité associée au rapprochement des plaques et à la déformation de l'arc des Antilles. Ce réseau a été récupéré au cours de la campagne OBSAntilles depuis le N/O Antéa de l'IRD qui a redéployé 30 OBS de Géoazur pour une nouvelle période de 4 mois.Il faut souligner l'importance de ce projet, au cours duquel pour la première fois jusqu'à 80 OBS déployés simultanément en mer et ont enregistré la sismicité pendant une période allant jusqu'à 6 à 7 mois.
Studies on the total synthesis of radicicol and its analogues
Creators: name: Lachs, Jennifer
Publisher: name: Imperial College London
Year: 2013

description: Recent research has shown radicicol (I) to be a potent and selective inhibitor of Hsp90, stimulating a renewed interest in this natural product.i,ii Using a new latestage aromatisation strategy developed in the group, a concise and convergent formal synthesis of radicicol (I) was achieved. Formation of the 14-membered macrocycle relied on a relay-ring-closing metathesis (RRCM) of precursor II using the 2nd generation Hoveyda-Grubbs catalyst. The key late-stage aromatisation sequence consisting of the thermal retro-Diels-Alder reaction of III followed by ketene trapping with IV was used to construct the aromatic resorcylate framework of II. The aromatic chlorination is literature-known, therefore the formal synthesis was completed.iii Studies were also carried out towards the synthesis of potentially active analogues using the same strategy which was applied to the formal synthesis of radicicol (I).
Supplementary document for Collison dynamics between soliton molecules and a single soliton: exploding soliton pair and periodic soliton explosions - 6916381.pdf
Creators: name: Liu, Runmin
name: Zou, Defeng
name: Song, Youjian
name: Hu, Ming-lie
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Nonlinear Optics and Spectroscopy

description: Supplement 1
The instructive role of cardiac transcription factors in triggering transition of cardiac progenitor cells into the cardiac muscle fate
Creators: name: Belian, Elisa
Publisher: name: Imperial College London
Year: 2013

description: The mechanisms that maintain cardiac progenitor cells (CPCs) in a state of arrested development and prevent their spontaneous differentiation are unknown. This study is aimed at investigating potential mechanisms responsible for the striking paradox of cardiac transcription factors' expression without activation of their direct cardiomyocyte-specific target genes. Expression analysis of a range of CPC-derived clonal lines, characterised by Sca-1 expression and the SP phenotype, showed that all analysed cardiac transcription factors are expressed as nuclear-localised proteins. Hence, the absence of nucleartargeted protein expression is not the reason for lack of transcriptional activity. Interestingly, none of the clones expressed the complete triad of Gata4, Mef2c and Tbx5 (GMT) that reportedly reprograms cardiac fibroblasts into cardiomyocytes. However, forced expression of the respective missing factor(s) in CPCs induced few of the tested cardiac markers, indicating that lack of co-expression of these three factors is not the reason for the cells' failure to undergo differentiation. As a third potential barrier, the cardiac muscle-specific isoform of the transcriptional coactivator Myocardin (Myocd) was investigated and found to be absent in all analysed clones. Conversely, rescue with exogenous Myocd plus Tbx5 was found to robustly activate nearly all tested RNA and protein markers diagnostic of the cardiomyocyte lineage. In summary, this study demonstrates that rescuing the lack of Myocd in combination with other cardiac transcription factors is sufficient to induce expression of a range of cardiac genes and proteins characteristic of differentiated cardiomyocytes, suggesting that the lack or insufficient level of these factors is a limiting mechanism maintaining CPCs in the undifferentiated state. Evidence presented in this study indicates that Myocd is not only crucial in regulating cardiac muscle formation during embryogenesis but pivotal to induce the transition of adult cardiac progenitor cells toward the cardiac muscle fate.
MARCHE
Creators: name: GOSLIN Jean
Publisher: name: Sismer
Year: 2006

description: L'objectif du "réseau MARCHE", constitué de quatre hydrophones autonomes, est d'observer l'activité sismique de la zone MOMAR à l'échelle régionale. Cet objectif était celui du WP1 "Monitoring the Ridge seismicity at a regional scale: hydro-acoustic monitoring" du Marie Curie Research Training Network "MoMARNet", placé sous la responsabilité scientifique de J. Goslin.Les trois déploiements de ce réseau ont été effectués dans le cadre d'une collaboration internationale, qui a débuté en 2000, entre quatre laboratoires : l'UMR6538 « Domaines Océaniques » de Brest et : Pacific Marine Environment Laboratory, NOAA/OSU, Portland, OR, USA. Estrutura de Missão para a Extensão da Plataforma Continental, Paço de Arcos, Portugal. Centro de Investigação Marinha e Ambiental, Universidade do Algarve, Faro, Portugal.Le réseau MARCHE a debuté en 2005 avec le déploiement des 2 hydrophones au sud du réseau (M6 et M7, figure1) lors de la campagne Knorr 182/3 et le déploiement 3 mois plus tard des 2 hydrophones au nord du réseau (M2 et M8, figure 1) lors de la campagne HYDRO-MoMAR05.En Avril 2006, les hydrophones ont été récupérés et redéployés lors de la campagne MARCHE1.En Juillet 2007, les hydrophones ont été récupérés et redéployés mais à des positions différentes pour trois sites (M6new, M7new et M8new, figure 1) lors de la campagne MARCHE2.Les quatre instruments mouillés en 2007 au cours de la campagne MARCHE2 ont été récupérés entre le 12 et le 20 août 2008 par le navire portugais NRP Gago Coutinho, lors de la campagne dédiée MARCHE3-2008 organisée et financée par nos partenaires portugais de l'EMEPC. (N. Lourenço, EPEMC et J. Goslin, CNRS/INSU UMR6538 co-chefs de mission). Les trois déploiements successifs du réseau MARCHE ont ainsi permis d'obtenir une série continue d'observations acoustiques d'une durée de trois ans, sur le chantier MOMAR à l'échelle régionale.Figure 1 : Routes du Suroît au cours des campagnes MACHE1/2006 et MARCHE2/2007. Les sites M2, M6, M7 et M8 étaient les sites occupés lors du premier déploiement de juillet 2005 à juillet 2007 (MARCHE1 et MARCHE2). Les sites M2, M6new, M7new, M8new concernent la période d'observation entre juillet 2007 à juillet 2008 (MARCHE 3). Le levé multi-faisceaux est indiqué au nord- ouest d'Horta (MARCHE2).
Phase Transition in Interacting Boson System at Finite Temperatures
Creators: name: Anchishkin, D.
name: Mishustin, I.
name: Stoecker, H.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Thermodynamical properties of an interacting boson system at finite temperatures and zero chemical potential are studied within the framework of the Skyrme-like mean-field toy model. It is assumed that the mean field contains both attractive and repulsive terms. Self-consistency relations between the mean field and thermodynamic functions are derived. It is shown that for sufficiently strong attractive interactions this system develops a first-order phase transition via formation of Bose condensate. An interesting prediction of the model is that the condensed phase is characterized by a constant total density of particles. The thermodynamical characteristics of the system are calculated for the liquid-gas and condensed phases. The energy density exhibits a jump at the critical temperature.
description: 17 pages, 7 figures, PDFLaTex, tiny corrections in the text were added
Unintended consequences of primary care quality improvement initiatives: A scoping review
Creators: name: Siriwardena, Aloysius Niroshan
name: Marishona Ortega
name: Orner, Roderick
name: Moradi, Pegah
name: Laparidou, Despina
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: Primary Care
subject: Medical Specialties
subject: Primary care
subject: Quality improvement initiatives
subject: Scoping review
subject: Unintended consequences

description: The objective of this scoping review is to document and classify the types and effects of unintended consequences recorded in published reports of primary care quality initiatives.
Evaluation of the role of the melanocortin receptor system in ischemia-reperfusion induced leukocyte endothelium interaction in the brain microcirculation
Creators: name: Holloway, Paul Matthew
Publisher: name: Imperial College London
Year: 2013

description: Leukocyte recruitment following cerebral ischemia reperfusion (I/R) has been shown to amplify inflammatory processes and enhance brain injury. Potent anti-inflammatory and neuro-protective properties have been attributed to the melanocortin receptor system, thus targeting this system may provide a novel therapeutic strategy for the treatment of stroke. Melanocortin receptor (MC) subtypes MC1, MC3 and MC4 have previously been shown to mediate MC anti-inflammatory actions, however their relative importance is poorly understood and may differ with the pathophysiological environment. In this study the bilateral common carotid artery occlusion (BCCAo) mouse model of global stroke was used with intravital microscopy to investigate the potential of melanocortin targeted compounds in modulating cerebral I/R induced leukocyte recruitment. While under basal conditions the cerebral microcirculation provides a poor substrate for leukocyte recruitment, BCCAo induced significant leukocyte recruitment by 40 min of reperfusion, with leukocyte rolling increasing from 21.5 cells/mm2/min to 191.0 cells/mm2/min and adhesion from 42.1 cells/mm2/min to 282.3 cells/mm2/min. Extending reperfusion to 2 h resulted in further increases in adhesion to 1500% of sham levels. Treatment with the non-selective melanocortin agonist, α-MSH, significantly reduced I/R induced leukocyte recruitment (Rolling by 80% at 40 min and 68% at 2 h and adhesion by 68% at 40 min and 82% at 2 h). The relative contributions of the melanocortin receptor subtypes were investigated in this model using MC selective compounds and receptor mutant mice. The MC1 selective BMS-470,539 provided most potent inhibition of leukocyte recruitment at 40 min with the MC1 mutant e/e mice also showing enhanced leukocyte rolling and circulating TNF-α, while MC3-/- mice showed no inflammatory phenotype. However by 2 h the inhibitory effects of BMS-470,539 subsided and e/e mice no longer showed abnormalities in leukocyte recruitment. On the other hand MC3 targeted compounds were highly effective at this later time point. These investigations reveal an important role for MC1 immediately following BCCAo with a later shift toward MC3 mediated processes by 2 h. Due to no observed changes in receptor mRNA and that by 2 h α-MSH treatment was found to reduce NF-κβ related gene expression but not at 40min. It is likely the apparent shift in receptor importance is due to the activation of distinct signalling pathways rather than change in receptor expression.
Reminiscences of Leslie Clarence Dunn, 1960
Publisher: name: Columbia University
Year: 2021
Subjects: subject: Geneticists
subject: Genetics
subject: FOS: Biological sciences
subject: Genetics--Research
subject: Plant genetics
subject: Population genetics
subject: Science and state--Soviet Union
subject: Human genetics

description: Training in the biological sciences in the United States from 1905; history of genetics in the United States, Great Britain, Germany, and Russia ; developmental genetics, interdisciplinary symposia, "Growth Symposia"; influence of genetics on pathological and biochemical researches; impressions of Soviet science and scientists: trip to Russia, 1927, Genetics Congress meeting at Columbia, 1932; plant breeding in Russia ; demise of Gorki Institute of Medico-Genetics and of some Soviet scientists during 1938 crisis; Lysenko school versus the Mendelist-Morganist-Weissmanist school; American-Soviet Science Society; scientific debates in Russia, 1936, 1938-1939, 1948. The Jackson Laboratory; experimental studies of wild mice; cytogenetics; population genetics and evolution; work in population genetics in Sweden; Institute for the Study of Human Variation; genetics studies in Japan; bacterial genetics; Nevis Biological Station; radiation and genetics; scientists and government; Columbia's Department of Zoology; chronological summary of developments in genetics. Impressions of William Castle, Thomas H. Morgan, William Bateson, Richard Goldschmidt, Alexander Serebrovskii, Nikolai Vavilov, Theodosius Dobzhansky, H.J. Muller, Trofim Lysenko, and others
Raphanus raphanistrum Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Brassicales
Brassicaceae
Raphanus
Raphanus raphanistrum

description: Raphanus raphanistrum Linnaeus, Species Plantarum 2: 669. 1753.
"Habitat inter segetes Europae." RCN: 4875.
Lectotype (Jonsell & Jarvis in Nordic J. Bot. 22: 71. 2002): Herb. Clifford: 340, Raphanus 2 (BM-000646374).
Current name: Raphanus raphanistrum L. (Brassicaceae).
Note: Jafri (in Nasir & Ali, Fl. W. Pakistan 55: 34. 1973) and later authors have treated 846.4 (LINN) as the type, but this collection was sent to Linnaeus by Brander and did not reach him until after 1753. It cannot, therefore, be original material for the name.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 788, DOI: 10.5281/zenodo.291971
Additional file 1 of Fatigue following radiotherapy of low-risk early breast cancer – a randomized controlled trial of intraoperative electron radiotherapy versus standard hypofractionated whole-breast radiotherapy: the COSMOPOLITAN trial (NCT03838419)
Creators: name: Forster, Tobias
name: Jäkel, Cornelia
name: Akbaba, Sati
name: Krug, David
name: Krempien, Robert
name: Uhl, Matthias
name: Häfner, Matthias Felix
name: König, Laila
name: Koerber, Stefan Alexander
name: Harrabi, Semi
name: Bernhardt, Denise
name: Behnisch, Rouven
name: Krisam, Johannes
name: Hennigs, Andre
name: Sohn, Christof
name: Heil, Jörg
name: Debus, Jürgen
name: Hörner-Rieber, Juliane
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Cell Biology
Pharmacology
Biotechnology
Cancer

description: Additional file 1. Supplementary material 1: Current version of the study protocol, version 1.1 from January, 24th 2019.
Invariant natural killer T cells in multiple sclerosis
Creators: name: Kamel, Fatemah Omar
Publisher: name: Imperial College London
Year: 2013

description: Invariant natural killer T (iNKT) cells are a subpopulation of lymphocytes that express both a CD1d-restricted αβ T cell receptor (TCR) and NK cell markers. iNKT cell perturbations are implicated in a wide variety of autoimmune diseases including Multiple Sclerosis (MS). Our results confirmed a significant reduction in the percentage of iNKT cells in MS patients with respect to healthy donors. In order to understand the immunological significance of iNKT cell reduction in MS, we aimed to define iNKT subsets in a cohort of MS patients of different disease types, Clinically Isolated Syndrome patients (CIS) and patients on different treatments by means of multiparameter flow cytometry and TCR analysis. TCR analysis showed that Vα24 CDR3 region is highly conserved between healthy controls and MS patients, while TCR Vβ11 CDR3 region in iNKT cells of MS patients appeared constrained relative to the pool of cells in healthy controls. As activation, differentiation and maturation processes can be involved in the reduced frequency of iNKT cells, we investigated the role of CD25, CD62L, CD69, CD161 and CD195. Initial observation suggested that co-expression of CD25 and CD161 on iNKT cells is significantly higher in MS patients compared to healthy controls, while CD161 alone is decreased, suggesting that a subpopulation of iNKT cells might be acting as “regulatory subsets” in MS. Because many genetic studies have shown that specific killer cell immunoglobulinlike receptor (KIR) family have a strong association with MS, we evaluated the expression of KIR2DL1/S1, KIR2DL2/L3 and KIR3DL1 on iNKT cells. Our results showed that expression of KIR2DL1/S1 and KIR3DL1 is lower in progressive MS patients compared to healthy controls. RRMS untreated patients have lower expression of both KIR2DL2/L3 and KIR3DL1 than patient treated with Natalizumab, while the contrary is true when looking at expression of KIR2DL1/S1. All together our data showed that perturbation of iNKT cells is associated with expression of specific surface receptors, thus defining subsets of iNKT cells that might be related to progression of disease or used as disease markers.
Electron acceleration in a JET disruption simulation
Creators: name: Sommariva, Cristian
name: Nardon, Eric
name: Beyer, Peter
name: Hoelzl, Matthias
name: Huijsman, Guido
Publisher: name: arXiv
Year: 2018
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Runaways are suprathermal electrons having sufficiently high energy to be continuously accelerated up to tens of MeV by a driving electric field [1]. Highly energetic runaway electron (RE) beams capable of damaging the tokamak first wall can be observed after a plasma disruption [2]. Therefore, it is of primary importance to fully understand their generation mechanisms in order to design mitigation systems able to guarantee safe tokamak operations. In a previous work, [3], a test particle tracker was introduced in the JOREK 3D non-linear MHD code and used for studying the electron confinement during a simulated JET-like disruption. It was found in [3] that relativistic electrons are not completely deconfined by the stochastic magnetic field taking place during the disruption thermal quench (TQ). This is due to the reformation of closed magnetic surfaces at the beginning of the current quench (CQ). This result was obtained neglecting the inductive electric field in order to avoid the unrealistic particle acceleration which otherwise would have happened due to the absence of collision effects. The present paper extends [3] analysing test electron dynamics in the same simulated JET-like disruption using the complete electric field. For doing so, a simplified collision model is introduced in the particle tracker guiding center equations. We show that electrons at thermal energies can become RE during or promptly after the TQ due to a combination of three phenomena: a first REs acceleration during the TQ due to the presence of a complex MHD-induced electric field, particle reconfinement caused by the fast reformation of closed magnetic surfaces after the TQ and a secondary acceleration induced by the CQ electric field.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Magny-lès-Aubigny et Montot (XVe siècle), Cart. 183 (11 H 821), 21 folios, f. 0020
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Cîteaux pour les possessions de Magny-lès-Aubigny et Montot (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 183 (11 H 821), 21 folios, f. 0020, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Magny-lès-Aubigny et Montot (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 183 (11 H 821), 21 folios, f. 0020, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Raphanus sativus Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Brassicales
Brassicaceae
Raphanus
Raphanus sativus

description: Raphanus sativus Linnaeus, Species Plantarum 2: 669. 1753.
"Habitat - - - –” RCN: 4873.
Lectotype (Jonsell in Humbert, Fl. Madagascar 84: 8. 1982): Herb. Linn. No. 846.1 (LINN). - Epitype (Pistrick & Jarvis in Feddes Repert. 98: 477. 1987): Herb. Burser IV: 52 (UPS).
Generitype of Raphanus Linnaeus (vide Green, Prop. Brit. Bot.: 172. 1929).
Current name: Raphanus sativus L. (Brassicaceae).
Note: Jonsell (in Humbert, Fl. Madagascar 84: 8. 1982) typified the name with 846.1 (LINN). However, the absence of a root (necessary to apply infraspecific nomenclature) caused Pistrick & Jarvis (in Feddes Repert. 98: 477. 1987) to reject Jonsell’s choice in favour of a more complete collection in Herb. Burser (UPS). Under Art. 9.17, however, Jonsell’s choice of lectotype must stand but Pistrick & Jarvis’ choice of the Burser material as lectotype, is correctable to an epitype (Art. 9.8).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 788, DOI: 10.5281/zenodo.291971
Declining Rotation Curve and Brown Dwarf MACHOs
Creators: name: Honma, Mareki
name: Kan-ya, Yukitoshi
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: If the Galactic rotation speed at the Solar circle is $\sim 200$ km s$^{-1}$ or smaller, which is supported by several recent studies, the rotation curve of the Galaxy could be declining in the outermost region. Motivated by this, we investigate the effect of such declining rotation curve on the estimate of the MACHO mass and the fractional contribution of the MACHOs to the Galactic dark halo. Using Hernquist and Plummer halo models instead of the standard halo model, we find that the MACHO mass could be significantly smaller than that for the standard halo case. In particular, there exists a certain set of halo parameters for which the MACHO mass is 0.1$M_\odot$ or less and at the same time the MACHO contribution to the total mass of the halo is almost 100 %. This result indicates that a halo which consists solely of brown dwarfs can be consistent with both of the observed microlensing properties and the constraints from the rotation curve, provided the outer rotation curve is indeed declining.
description: 8 pages and 4 figures, accepted for publication in ApJ Letters
Supplementary document for Unsupervised Spectral Reconstruction from RGB images under Two Lighting Conditions - 6888822.pdf
Creators: name: Cao, Xuheng
name: Lian, Yusheng
name: Liu, Zilong
name: Li, Jin
name: Wang, Kaixuan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplement 1
Narrowing of Bennett Hole in Collisional Plasma
Creators: name: Podivilov, E. V.
name: Shapiro, D. A.
name: Stepanov, M. G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The profile of a Bennett hole induced by laser field in ionic distribution in collisional plasma is calculated. Influence of Chandrasekhar's dependence of coefficients of velocity space transport on the profile is included into the calculation for the first time. It is found that the hole narrows down as the field detuning frequency increases. Physical cause of the effect is the falling dependence of Coulomb collision frequency on the ionic velocity. Estimations show that the effect is quite observable under conditions of high-current gas-discharge plasma.
description: 5 pages, RevTeX + 1 postscript figure in a compressed and file
RECOSOM
Creators: name: SIMPLET Laure
Publisher: name: Sismer
Year: 2010

description: Elles devaient compléter la reconnaissance de la couverture sédimentaire meuble au large de la baie de Somme et de ses abords réalisée lors des campagnes ESTUNORD (Haliotis 2009). Par ailleurs, le secteur sensu stricto de la baie de Somme n'avait jusqu'alors jamais fait l'objet de reconnaissance générale, hormis les levés hydrographiques du SHOM qui sont parfois anciens.Il s'agissait dans le cadre de ce projet de réaliser une cartographie géologique permettant de joindre les levés réalisés dans le Nord Pas-de-Calais (Projet GRANOR 1984, 1985) (au Nord de la zone) et au large de Dieppe (suivi quadriennal de la centrale nucléaire de Penly), ainsi que les levés du SHOM (parfois anciens), de l'Université de Lille (ESTUNORD - Haliotis 2009) et de l'Université de Rouen au Sud de la zone (MOSAG, SISCOSAG).Les données acquises principalement par Ifremer avec un objectif de cartographie sont mises à dispositions des équipes partenaires des Universités de Lille et Rouen et permettront également de répondre aux objectifs scientifiques portant sur : la terminaison/naissance des grands bancs du Nord Pas-de-Calais ; les processus de comblement des estuaires picards ainsi que les modalités du transfert de sédiments entre la côte et la plate-forme ; le tracé des paléocours de la Somme, de l'Authie et de la Canche ainsi que la nature et l'architecture des unités constituant leur remplissage.
Differential Rotation and Turbulence in Extended HI Disks
Creators: name: Sellwood, J. A.
name: Balbus, S. A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: When present, extended disks of neutral hydrogen around spiral galaxies show a remarkably uniform velocity dispersion of approx 6 km/s. Since stellar winds and supernovae are largely absent in such regions, neither the magnitude nor the constancy of this number can be accounted for in the classical picture in which interstellar turbulence is driven by stellar energy sources. Here we suggest that magnetic fields with strengths of a few microgauss in these extended disks allow energy to be extracted from galactic differential rotation through MHD driven turbulence. The magnitude and constancy of the observed velocity dispersion may be understood if its value is Alfvenic. Moreover, by providing a simple explanation for a lower bound to the gaseous velocity fluctuations, MHD processes may account for the sharp outer edge to star formation in galaxy disks.
description: 9 pages, no figures, to appear in ApJ, LaTeX uses aas2pp4.sty, eliminated duplicate paragraph
MOOGLI
Creators: name: RAIMBAULT Patrick
Publisher: name: Sismer
Year: 1998

description: Le programme MOOGLI (MOdélisation et Observation du Golfe du Lion), qui relève du Programme National d'Océanographie Côtière, PNOC), a pour objectif l'étude de l'évolution saisonnière de la structure et du fonctionnement de l'écosystème du golfe du Lion. Cette région côtière est physiquement gouvernée par une structure hydrodynamique puissante, le courant Nord-Méditerranéen (CNM), et est soumise à d'importants apports continentaux par le Rhône.Ce programme s'est déroulé au cours de 3 campagnes, 2 reliées à cette série, mais également sur MOOGLI1.
Radiation Rates for Low Z Impurities in Edge Plasmas
Creators: name: Clark, R.
name: Abdallah, J.
name: Post, D.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The role of impurity radiation in the reduction of heat loads on divertor plates in present experiments such as DIII-D, JET, JT-60, ASDEX, and Alcator C-Mod, and in planned experiments such as ITER and TPX places a new degree of importance on the accuracy of impurity radiation emission rates for electron temperatures below 250 eV for ITER and below 150 eV for present experiments. We have calculated the radiated power loss using a collisional radiative model for Be, B, C, Ne and Ar using a multiple configuration interaction model which includes density dependent effects, as well as a very detailed treatment of the energy levels and meta-stable levels. The "collisional radiative" effects are very important for Be at temperatures below 10 eV. The same effects are present for higher Z impurities, but not as strongly. For some of the lower Z elements, the new rates are about a factor of two lower than those from a widely used, simpler average-ion package (ADPAK) developed for high Z ions and for higher temperatures. Following the approach of Lengyel for the case where electron heat conduction is the dominant mechanism for heat transport along field lines, our analysis indicates that significant enhancements of the radiation losses above collisional radiative model rates due to such effects as rapid recycling and charge exchange recombination will be necessary for impurity radiation to reduce the peak heat loads on divertor plates for high heat flux experiments such as ITER.
description: Preprint for the 11th PSI meeting, gzipped postscript with 11 figures, 14 pages
Fluorescence lifetime imaging applied to multiwell plate FRET assays for high content analysis
Creators: name: Alibhai, Dominic
Publisher: name: Imperial College London
Year: 2013

description: The work reported in this thesis aims to develop and apply new assays for high content analysis (HCA) based on novel automated fluorescence lifetime imaging microscopy (FLIM) technology adapted for multiwell plate readers and evaluate their potential for drug discovery. Two such FLIM multiwell plate readers were investigated, one based on a custom-modified commercially available plate reader (GE Healthcare In Cell 1000) and the other based on an Olympus IX-81 wide-field microscope adapted for use as an automated multiwell plate imaging system. To evaluate the potential for drug discovery, an exemplar assay of HIV-1 Gag protein aggregation was developed and used to evaluate the performance of the multiwell plate readers. HIV-1 Gag is the major structural protein within HIV-1 virions and is thought to interact with other viral proteins, the viral genome and with a large number of host cell factors to orchestrate the formation of new virions. HIV-1 Gag protein oligomerisation is a precursor to virion production at the plasma membrane of the target cell during the HIV virus life cycle and so represents a potential readout for testing the efficacy of anti HIV drugs. The expression of HIV-1 Gag alone within living cells leads to the formation of virus-like particles (VLPs), which provide a convenient and safe means to study this late stage of the HIV cycle. This exemplar assay is based on Förster Resonance Energy Transfer (FRET) between appropriately (fluorescently) labelled HIV-1 Gag proteins. By tagging HIV-1 Gag proteins with either a donor fluorophore or an acceptor fluorophore, a FRET signal can be utilised to indicate when the oligomerisation brings the donor and acceptor within close (
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0727
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0727, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0727, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 2: of Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis
Creators: name: Petrusca, Daniela
name: Toscani, Denise
name: Wang, Feng-Ming
name: Park, Cheolkyu
name: Crean, Colin
name: Anderson, Judith
name: Marino, Silvia
name: Mohammad, Khalid
name: Zhou, Dan
name: Silbermann, Rebecca
name: Sun, Quanhong
name: Kurihara, Noriyoshi
name: Galson, Deborah
name: Giuliani, Nicola
name: Roodman, G
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Chemicals and antibodies; Plasmid and lentiviral constructs; Immunoprecipitation and Western blotting; qPCR; ChIP assay; Immunofluorescence. (DOCX 22 kb)
Baryogenesis through gradual collapse of vortons
Creators: name: Masperi, Luis
name: Orsaria, Milva
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We evaluate the matter-antimatter asymmetry produced by emission of fermionic carriers from vortons which are assumed to be destabilized at the electroweak phase transition.The velocity of contraction of the vorton, calculated through the decrease of its magnetic energy, originates a chemical potential which allows a baryogenesis of the order of the observed value. This asymmetry is not diluted by reheating if the collapse of vortons is distributed along an interval of ~ 10^-9 sec.
description: 14 pages, Latex, no figures
JERICOBENT
Creators: name: DEFLANDRE Bruno
Publisher: name: Sismer
Year: 2016

description: Un premier objectif des campagnes JERICObent (1-4, 6) est de déterminer les rôles respectifs des fluctuations temporelles des apports sédimentaires de la Gironde et de l'hydrodynamisme du milieu récepteur dans la structuration et le fonctionnement de son écosystème benthique. Pour cela, la description des patrons spatio-temporels de la structuration (e.g. Matière Organique, micro-, meio- et macrofaune) et du fonctionnement (e.g. minéralisation de la MO sédimentaire, bioturbation) de l'interface eau-sédiment est recherché à partir d'un échantillonnage saisonnier et la mise en relation de ses variations avec les dynamiques temporelles des apports sédimentaires et de l'hydrodynamisme à l'échelle infra-saisonnière. Cette étude permettra in fine une comparaison avec le système Rhône aussi reconnu comme un tributaire continentale majeur de la Méditerranée, la système Rhône ayant été activement étudié par notre groupe ces dix dernières années.Un second objectif majeur des campagnes JERICObent (5, Legs 1 & 2) a consisté à dresser une première cartographie réellement synoptique de la Vasière Ouest Gironde en juin-juillet 2018, élément de référence indispensable à la mise en relation de l'évolution future de sa délimitation en lien avec les variations (supra-saisonnières) des apports sédimentaires et des événements hydrodynamiques majeurs. La dernière cartographie datant de 2016 est basée sur un ensemble d'informations sédimentaires répertoriées sur une période de 30 ans, si bien qu'elle reflète bien plus l'expansion maximale de la VOG au cours de cette période que sa délimitation actuelle.Le troisième objectif des campagnes JERICObent (7 et 7-2021 ; juillet 2019 & 2021) est de caractériser la structure et le fonctionnement de la VOG sur une échelle de temps géologique. Accéder à de longues carottes de sédiment (entre 2 et 4 m de profondeur) prélevées à l'aide d'un carottier Kullenberg permettra de couvrir une période pouvant atteindre jusqu'à 4 360 années (Lesueur et al 2002), permettant ainsi de mieux préciser sa structure et son fonctionnement sur une plus longue période de temps géologique que les précédentes campagnes JERICObent (1-4, 6) qui ne couvraient que l'aspect saisonnier.Le quatrième et dernier objectif majeur des campagnes JERICObent (8, Juillet 2020) est de caractériser la variabilité spatiale des taux de minéralisation de la MO sédimentaire à l'échelle de la VOG. Pour cela, un profileur de microélectrodes autonome permettra de mesurer in-situ les distributions verticales de l'oxygène dissous dans le sédiment de la vasière (environ 25 stations, 10-15 réplicas par station), à partir desquelles les taux de minéralisation seront calculés par modélisation. Cette campagne bouclera ainsi le travail que nous menons ainsi depuis 2016 sur la VOG.
Chorispora sibirica
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Brassicales
Brassicaceae
Chorispora
Chorispora sibirica

description: Raphanus sibiricus Linnaeus, Species Plantarum 2: 669. 1753.
"Habitat in Sibiria." RCN: 4876.
Lectotype (Ebel in Cafferty & Jarvis in Taxon 51: 535. 2002): Herb. Linn. No. 846.6 (LINN).
Current name: Chorispora sibirica (L.) DC. (Brassicaceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 788, DOI: 10.5281/zenodo.291971
Analytic Criteria for Power Exhaust in Divertors due to Impurity Radiation
Creators: name: Post, D.
name: Putvinskaya, N.
name: Perkins, F. W.
name: Nevins, W.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Present divertor concepts for next step experiments such ITER and TPX rely upon impurity and hydrogen radiation to transfer the energy from the edge plasma to the main chamber and divertor chamber walls. The efficiency of these processes depends strongly on the heat flux, the impurity species, and the connection length. Using a database for impurity radiation rates constructed from the ADPAK code package, we have developed criteria for the required impurity fraction, impurity species, connection length and electron temperature and density at the mid-plane. Consistent with previous work, we find that the impurity radiation from coronal equilibrium rates is, in general, not adequate to exhaust the highest expected heating powers in present and future experiments. As suggested by others, we examine the effects of enhancing the radiation rates with charge exchange recombination and impurity recycling, and develop criteria for the minimum neutral fraction and impurity recycling rate that is required to exhaust a specified power. We also use this criteria to find the optimum impurity for divertor power exhaust.
description: Preprint for the 11th PSI meeting, Adobe pdf with 14 figures, 15 pages