cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Market Communication Strategy
Creators: name: McElroy, Lory
name: Garving, Stephen
Publisher: name: Zenodo
Year: 2016
Subjects: Communication Strategy
Social Media

description: This document sets out the HIT2GAP Marketing and Communications strategy and the roles and responsibilities of all 22 Project Partners in delivering the project aims how success will be measured. The general objective of all project communications is to ensure that any useful outcomes of the project are effectively deployed. This communications strategy is developed in line with EU guidelines, by BRE in co-operation with other partners. It demonstrates how the project’s key messages and results will be disseminated and communicated across the project length. This includes elements such as the target groups, with tools and key actions.
Additional file 1 of Clinical sepsis phenotypes in critically ill COVID-19 patients
Creators: name: Bruse, Niklas
name: Kooistra, Emma J.
name: Jansen, Aron
name: van Amstel, Rombout B. E.
name: de Keizer, Nicolette F.
name: Kennedy, Jason N.
name: Seymour, Christopher
name: van Vught, Lonneke A.
name: Pickkers, Peter
name: Kox, Matthijs
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Online Supplement containing Supplementary Methods and Supplementary Table 1-6.
Additional file 1 of Which countries need COVID-19 vaccines the most? Development of a prioritisation tool
Creators: name: Jain, Vageesh
name: Atun, Rifat
name: Hansen, Paul
name: Lorgelly, Paula
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file 1.
Ship-based lidar evaluation of Southern Ocean clouds in the storm-resolving general circulation model ICON and the ERA5 and MERRA-2 reanalyses
Creators: name: Kuma, Peter
name: Bender, Frida A.-M.
name: McDonald, Adrian J.
name: Alexander, Simon P.
name: McFarquhar, Greg M.
name: Cassano, John J.
name: Plank, Graeme E.
name: Hartery, Sean
name: Parsons, Simon
name: Garrett, Sally
name: Schuddeboom, Alex J.
Publisher: name: Zenodo
Year: 2024

description: Global storm-resolving models (GSRMs) are the next avenue of climate modelling. Among them is the 5-km Icosahedral Nonhydrostatic Weather and Climate Model (ICON). The high resolution allows for parameterizations of convection and clouds to be avoided. Standard-resolution models have substantial cloud biases over the Southern Ocean (SO), affecting radiation and sea surface temperature. We evaluated SO clouds in ICON and the ERA5 and MERRA-2 reanalyses. The SO is dominated by low clouds, which cannot be observed accurately from space due to overlapping clouds, attenuation, and ground clutter. Instead, we analysed about 2400 days of lidar observations from 31 voyages and a station using a ground-based lidar simulator. ICON and the reanalyses underestimate the total cloud fraction by about 10 and 20%, respectively. ICON and ERA5 overestimate the cloud occurrence peak at about 500 m, potentially explained by their lifting condensation levels being too high. The reanalyses strongly underestimate near-surface clouds or fog. MERRA-2 tends to underestimate cloud occurrence at all heights. Less stable conditions are the most problematic for ICON and the reanalyses. In daily cloud cover, ICON and the reanalyses tend to be about 1 and 2 oktas clearer, respectively. Compared to radiosondes, potential temperature is accurate in the reanalyses, but ICON underestimates stability over the low-latitude SO and too humid in the boundary layer. MERRA-2 is too humid at all heights. SO cloud biases remain a substantial issue in the GSRM, but are an improvement over the lower-resolution reanalyses. Explicitly resolved convection and cloud processes were not enough to address the model cloud biases.
Additional file 1 of Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium
Creators: name: Léger, Corentin
name: Pitard, Irène
name: Sadi, Mirko
name: Carvalho, Nicolas
name: Brier, Sébastien
name: Mechaly, Ariel
name: Raoux-Barbot, Dorothée
name: Davi, Maryline
name: Hoos, Sylviane
name: Weber, Patrick
name: Vachette, Patrice
name: Durand, Dominique
name: Haouz, Ahmed
name: Guijarro, J. Iñaki
name: Ladant, Daniel
name: Chenal, Alexandre
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Synchrotron radiation far-UV circular dichroism. Figure S2. Isothermal titration calorimetry of holo-CaM:CDZ. Figure S3. Analysis of holo-CaM using SAXS. Table S1. SAXS data collection and scattering derived parameters. Table S2. Crystallographic data collection and refinement statistics. Figure S4. Difference electron density map. Figure S5. Interactions between CDZ and holo-CaM residues visualized using Ligplot+. Table S3. Detailed location of residues interacting with CDZ according to Ligplot+ and comparison with HDX-MS data. Table S4. HDX-MS data summary. Figure S6. Peptide map of CaM by HDX-MS. Figure S7. Deuterium uptake plots. Figure S8. Comparison of the differential HDX patterns within holo-CaM upon H-helix (A), P454 (B), MLCK (C) and CDZ (D) binding. Table S5. Rotational correlation time (τc) of holo-CaM at different holo-CaM:CDZ ratios. Table S6. Comparison of secondary structure content from SRCD, NMR and X-ray. Figure S9. Order parameter (S2) reflecting the amplitude of motions on the ns-ps time scales of free holo-CaM. Figure S10. holo-CaM internal dynamics from 15N relaxation data. Figure S11. Comparison of holo-CaM internal dynamics from 15N relaxation data in complex with CDZ. Figure S12. Statistical analysis performed with MEMHDX.
Distúrbios Hipertensivos na Gestação: Classificações e Tratamentos
Creators: name: Mayana Sá Barreto Lopes
name: Leonardo Aguiar Muniz Feitosa
name: Cristiane Tavares Rabelo de Castro
name: Daniel Victor Gadas Pereira
name: Mônica Santos Primeira
name: Mirella Loureiro de Almeida
name: Carlos Antônio Carvalhaes Filho
name: Maria do Carmo Borges Sousa
name: Ricardo Hendges
name: Isabella Cristyne Alves Mendanha
Publisher: name: Zenodo
Year: 2025

description: Os distúrbios hipertensivos na gravidez representam uma condição de grande relevância na obstetrícia, sendo uma das principais causas de morbidade e mortalidade materna e fetal em todo o mundo. Essas complicações abrangem desde a hipertensão gestacional, a pré-eclâmpsia até a eclâmpsia, cada uma com características distintas e potencial impacto adverso na saúde da gestante e do feto. Portanto, este estudo tem como objetivo realizar uma revisão integrativa da literatura sobre os distúrbios hipertensivos na gravidez, a fim de compreender suas características, fatores de risco, diagnóstico, manejo clínico e impacto na saúde materno-fetal. Para realizar esta revisão integrativa, foram consultadas bases de dados eletrônicas, como PubMed, Scopus, Lilacs e Google Scholar, utilizando os seguintes descritores: "distúrbios hipertensivos na gravidez", "hipertensão gestacional", "pré-eclâmpsia", "eclâmpsia", "fatores de risco" e "manejo clínico". Foram incluídos estudos publicados nos últimos dez anos, escritos em português, espanhol ou inglês, a fim de abranger as evidências mais recentes relacionadas a essas condições. Os distúrbios hipertensivos na gravidez são uma preocupação significativa em saúde materna e fetal. Esta revisão integrativa da literatura permitiu uma análise abrangente dessas condições, identificando os fatores de risco, as características clínicas, os métodos de diagnóstico e as estratégias de manejo clínico recomendadas. A compreensão desses distúrbios é fundamental para melhorar a prevenção, o diagnóstico precoce e o tratamento, com o objetivo de reduzir a morbidade e a mortalidade materna e fetal associada a essas complicações.
Additional file 1 of Risk factors for missed abortion: retrospective analysis of a single institution’s experience
Creators: name: Jiang, Wei-Zhen
name: Yang, Xi-Lin
name: Luo, Jian-Ru
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file 1: Supplementary Figure 1. Flow chart depicting for inclusion of studysubjects. Supplementary Table1. Clinical characteristicsof participants.
Additional file 1 of Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in Australian primary care patients: only part of the story?
Creators: name: Orji, Nneka
name: Campbell, Julie A.
name: Wills, Karen
name: Hensher, Martin
name: Palmer, Andrew J.
name: Rogerson, Melissa
name: Kelly, Ryan
name: de Graaff, Barbara
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file1: Appendix 1. Potential reasons for an underestimate of prevalence of ME/CFS in the primary care setting.
SHE'RIY MATNLARDA METAFORIK BIRLIKLARNING QO'LLANISH USULLARI  (SHAVKAT RAHMON SHE'RLARI MISOLIDA)
Creators: name: Yunusova, Durdona
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada Shavkat Rahmon qalamiga mansub she’rlarda metaforalarning hosil bo’lish usullari haqida fikr yuritilgan bo’lib, unda muallif she’rlarida qo’llangan metaforik birliklarning o’zaro farqli ma’noviy va shakliy xususiyatlari tahlil etilgan.
Additional file 1 of The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice
Creators: name: Sobolewski, Marissa
name: Conrad, Katherine
name: Marvin, Elena
name: Eckard, Matthew
name: Goeke, Calla M.
name: Merrill, Alyssa K.
name: Welle, Kevin
name: Jackson, Brian P.
name: Gelein, Robert
name: Chalupa, David
name: Oberdörster, Günter
name: Cory-Slechta, Deborah A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplemental Figure 1: Group mean ± S.E. percent change relative to filtered air control of frontal cortex neurotransmitter levels at PND60 in males and females exposed to Fe only or Fe + SO2. *= significantly different from filtered air control; ~=marginally different from filtered air control; n=8/group. DA=dopamine; DOPAC=3,4-dihydroxyphenylacetic acid; HVA=homovanillic acid, Tyr=tyrosine; NE=norepinephrine, Gln=glutamine; Glu=glutamate; GABA=gabba-aminobutyric acid; 5HT=serotonin; 5-HIAA=5 hydroxyindoleacetic acid; 5-HTP=5-hydroxytryptophan; Kyn=kynurenine; n=7-8/group. Supplemental Figure 2: Group mean ± S.E. percent change relative to filtered air control of striatal neurotransmitter levels at PND60 in males and females exposed to Fe only or Fe + SO2. *= significantly different from filtered air control; ~=marginally different from filtered air control; n=8/group. DA=dopamine; DOPAC=3,4-dihydroxyphenylacetic acid; HVA=homovanillic acid, Tyr=tyrosine; NE=norepinephrine, Gln=glutamine; Glu=glutamate; GABA=gabba-aminobutyric acid; 5HT=serotonin; 5-HIAA=5 hydroxyindoleacetic acid; 5-HTP=5-hydroxytryptophan; Kyn=kynurenine; n=9-10/group.
Text: The Alpha-Ketoacid Dehydrogenase Complexes of Drosophila melanogaster.
Creators: name: Marygold, Steven J
Publisher: name: CaltechDATA
Year: 2024
Subjects: drosophila

description: Current GO terms relevant to the complexes and catalytic activities shown in Table 1, following their revision. Entries are taken from the go-basic.obo file (data-version: releases/2024-03-28) obtained from http://current.geneontology.org/ontology/go-basic.obo.
title: Cutaneous Amylosis and Rheumatoid Arthritis: About a case
title: Amylose cutanée et polyarthrite rhumatoïde : à propos d’un cas.
Creators: name: Youssoufi, Tarik
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2018
Subjects: 6 cas, polyarthrite rhumatoïde ; lichen cutané ; amylose primitive.

description: Amyloidosis is unusual disease that can affect many organs in a highly variable way. It is characterized by an accumulation of tissue deposits of proteins able to adopt an abnormal fibrillar conformation (called amyloid substance) and of which the β-pleated structure is resistant to proteolysis.
We distinguish amyloidosis AL (primitive) isolated or associated with myeloma, of which often belongs amyloid lichen and amyloidosis AA (secondary or reactive), with an infection, chronic inflammation, tumors... The combination of the secondary form to rheumatoid arthritis remains the most common. However, the association of rheumatoid arthritis to cutaneous lichen has rarely been described in the literature.
We report the observation of a 61 years old man followed for 20 years for rheumatoid arthritis that is deforming and destructive. He has been present for 2 years an erythemato-papulo- squamous plates spread on the anterior face of the 2 legs. The cutaneous biopsy was in favour of an amyloid lichen. The extensive assessment
did not find any systemic impairment.
description: L’amylose est une maladie rare qui peut toucher un grand nombre d’organes de manière très variable. Elle se caractérise par une accumulation de dépôts tissulaires de protéines capables d’adopter une conformation fibrillaire anormale (dite substance amyloïde) et dont la structure ß plissée résiste à la protéolyse.
On distingue l’amyloses AL (primitive) isolée ou associée au myélome, dont fait partie souvent le lichen amyloïde, et l’amylose AA (secondaire ou réactionnelle) à une infection, inflammation chronique, tumeurs ... L’association de la forme secondaire à la polyarthrite rhumatoïde reste la plus fréquente. Cependant l’association de la polyarthrite rhumatoïde au lichen cutané est rare et peu décrite dans la littérature.
Nous rapportons l’observation d’un homme de 61 ans suivie depuis 2O ans pour une polyarthrite rhumatoïde séropositive déformante et destructrice. Il présente depuis 2 ans des plaques érythémato- papulo-squameuses étendues sur la face antérieure des 2 jambes. La biopsie cutanée était en faveur d’un lichen amyloïde. Le bilan d’extension ne trouvait pas d’atteinte
systémique.
Dissemination And Awareness Activities Reporting Period 1 – (M01-M18)
Creators: name: Blanes Restoy, Luis Miguel
name: McCabe, Bryan
name: Keane, Marcus M.
name: Monaghan, Rory
Publisher: name: Zenodo
Year: 2017
Subjects: Communication Strategy
Market Diffusion
Scientific Diffusion

description: This deliverable presents the dissemination and awareness activities conducted by the HIT2GAP project partners according to the marketing strategies planned in Work Package 7 and defined in Deliverable 7.2 – “Marketing Communication Strategy”. The report describes in detail these activities in the next sections as follows, organized in categories:

	Section 2 – Introduces the overall marketing and dissemination strategy followed aligned with the scientific objectives of HIT2GAP;
	Section 3 – Market Diffusion activities focuses on describing market oriented activities carried out by the project partners. Updated information regarding National Stakeholders Forums is reported in this section. Additionally, EU events and R&D dissemination and awareness activities are also described;
	Section 4 - Scientific Diffusion activities deals with (1) Scientific peer reviewed journal publications planned, submitted or published by the HIT2GAP project partners and (2) Conference Communications (Conference Papers, Poster Presentation, Short Communication);
	Section 5 – Social Media Communications describes activity metrics and estimated reach of social media instruments such as Flipboard, LinkedIn groups or Twitter, and covers mass media and other communications;
	Section 6 – Compendium summarizes the activities carried out by the consortium members alongside with estimated audience reach, as an abridged account of the HIT2GAP dissemination efforts till date.
Grillas de evaluación PICTO 2021 Malvinas, Antártida y Atlántico Sur
Creators: name: Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación
Publisher: name: Zenodo
Year: 2022
Subjects: Evaluación científica

description: Formulario de evaluación de la convocatoria PICTO-2021 Malvinas, Antártida y Atlántico Sur.
Additional file 1 of The risk of newly diagnosed cancer in patients with rheumatoid arthritis by TNF inhibitor use: a nationwide cohort study
Creators: name: Choi, Boyoon
name: Park, Hyun Jin
name: Song, Yun-Kyoung
name: Oh, Yoon-Jeong
name: Kim, In-Wha
name: Oh, Jung Mi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Multivariable Analysis for Cancer Risk. Table S2. Subgroup analysis for Cancer Risk in the matched cohort. Table S3. Sensitivity Analysis for Cancer Risk in the matched cohort.
Determination of $\mathcal{CP}$-violating $HZZ$ interaction with polarised beams at the ILC
Creators: name: Li, Cheng
name: Moortgat-Pick, Gudrid
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2024
Subjects: CP: violation
muon: pair
boson: coupling
muon: angular distribution
polarization: longitudinal
beam: polarization
boson: decay
transverse
ILC Coll
tree approximation
sensitivity
polarized beam
asymmetry
total cross section
statistical
electron positron

description: We study possible $\mathcal{CP}$-violation effects of the 125 GeV Higgs to $Z$ boson coupling at the 250 GeV ILC with transverse and longitudinal beam polarisation via the process $e^+ e^- \rightarrow HZ \rightarrow H \mu^-\mu^+$. We explore the azimuthal angular distribution of the muon pair from the $Z$ boson decay, and constructe $\mathcal{CP}$-odd observables sensitive to $\mathcal{CP}$-violation effects, where we derived this observable both by analytical calculations and by $\mathtt{Whizard}$ simulations. Particularly, we can construct two $\mathcal{CP}$-odd observables with the help of transversely-polarised initial beams and improve the statistical significance of $\mathcal{CP}$-violation effects by combining two measurements. We defined the asymmetries between the signal regions with different signs of the $\mathcal{CP}$-odd observables, and determine the $\mathcal{CP}$-violation effect by comparing with the SM 95% C.L. upper bound. In this paper, we setup a scenario which assumes that the total cross-section is always fixed while $\mathcal{CP}$-violation is varying, and such a scenario helps us to determine the intrinsic $\mathcal{CP}$-mixing angle limit around $|\xi_{CP}|\sim 0.03$ with (90%, 40%) polarised electron-positron beams and 5 ab$^{-1}$ integrated luminosity. In addition, we determine the $\mathcal{CP}$-odd coupling limit $|\widetilde{c}_{HZZ}|\sim 0.01$ as well, where we suppose that the SM tree-level cross-section is fixed and the $\mathcal{CP}$-violation is the varying additional contribution. Comparing with the analysis with unpolarised beams, the sensitivity to the $\mathcal{CP}$-violation effect can be improved by transverse or longitudinal polarisation.
Additional file 2 of The risk of newly diagnosed cancer in patients with rheumatoid arthritis by TNF inhibitor use: a nationwide cohort study
Creators: name: Choi, Boyoon
name: Park, Hyun Jin
name: Song, Yun-Kyoung
name: Oh, Yoon-Jeong
name: Kim, In-Wha
name: Oh, Jung Mi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Figure S1. The Kaplan Meyer curves for cancer-free proportions. A The Kaplan Meyer curves for the before-matching cohort. B The Kaplan Meyer curves for the matched cohort.
Additional file 1 of Successes and lessons learned in database development for national multi-site cancer care delivery research trials: the Alliance for Clinical Trials in Oncology experience
Creators: name: Zahrieh, David
name: Hillman, Shauna L.
name: Tan, Angelina D.
name: Frank, Jennifer L.
name: Dockter, Travis
name: Meyers, Bobbi Jo
name: Cherevko, Cassie L.
name: Peil, Elizabeth S.
name: McCue, Shaylene
name: Kour, Oudom
name: Gunn, Heather J.
name: Neuman, Heather B.
name: Chang, George J.
name: Paskett, Electra D.
name: Mandrekar, Sumithra J.
name: Dueck, Amylou C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Appendix I. Rave Case Report Forms to Capture Monthly Practice Data for Trials A231601CD and A231901CD.
Pontocerebellar hypoplasia type 1
Creators: name: Llorens, Roberto
Publisher: name: EURORAD
Year: 2018
Subjects: subject: Neuroradiology brain
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Congenital

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 1 days
description: Clinical History: A male term newborn presents with hypotonia, bradycardia and significant respiratory distress.  No particular incidences were documented during pregnancy. There was no family background of congenital disease. Final Diagnosis: Pontocerebellar hypoplasia type 1
Comparing Predictive Accuracy in the Presence of a Loss Function Shape Parameter
Creators: name: Barendse, Sander
name: Patton, Andrew J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We develop tests for out-of-sample forecast comparisons based on loss functions that contain shape parameters. Examples include comparisons using average utility across a range of values for the level of risk aversion, comparisons of forecast accuracy using characteristics of a portfolio return across a range of values for the portfolio weight vector, and comparisons using recently-proposed “Murphy diagrams” for classes of consistent scoring rules. An extensive Monte Carlo study verifies that our tests have good size and power properties in realistic sample sizes, particularly when compared with existing methods which break down when then number of values considered for the shape parameter grows. We present three empirical illustrations of the new test.
Testing for Common Trends in Nonstationary Large Datasets
Creators: name: Barigozzi, Matteo
name: Trapani, Lorenzo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We propose a testing-based procedure to determine the number of common trends in a large nonstationary dataset. Our procedure is based on a factor representation, where we determine whether there are (and how many) common factors (i) with linear trends, and (ii) with stochastic trends. Cointegration among the factors is also permitted. Our analysis is based on the fact that those largest eigenvalues of a suitably scaled covariance matrix of the data corresponding to the common factor part diverge, as the dimension N of the dataset diverges, whilst the others stay bounded. Therefore, we propose a class of randomized test statistics for the null that the pth largest eigenvalue diverges, based directly on the estimated eigenvalue. The tests only requires minimal assumptions on the data-generating process. Monte Carlo evidence shows that our procedure has very good finite sample properties, clearly dominating competing approaches when no common trends are present. We illustrate our methodology through an application to the U.S. bond yields with different maturities observed over the last 30 years.
Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics.
Creators: name: Biggs, George S
name: Cawood, Emma E
name: Vuorinen, Aini
name: McCarthy, William J
name: Wilders, Harry
name: Riziotis, Ioannis G
name: van der Zouwen, Antonie J
name: Pettinger, Jonathan
name: Nightingale, Luke
name: Chen, Peiling
name: Powell, Andrew J
name: House, David
name: Boulton, Simon J
name: Skehel, J Mark
name: Rittinger, Katrin
name: Bush, Jacob T
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Chemical Biology & High Throughput
subject: Chemical Biology & High Throughput

description: Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel chemical probes to study protein function. Screening libraries of reactive fragments by chemoproteomics offers a compelling approach to ligand discovery, however, optimising sample throughput, proteomic depth, and data reproducibility remains a key challenge. We report a versatile, label-free quantification proteomics platform for competitive profiling of cysteine-reactive fragments against the native proteome. This high-throughput platform combines SP4 plate-based sample preparation with rapid chromatographic gradients. Data-independent acquisition performed on a Bruker timsTOF Pro 2 consistently identified ~23,000 cysteine sites per run, with a total of ~32,000 cysteine sites profiled in HEK293T and Jurkat lysate. Crucially, this depth in cysteinome coverage is met with high data completeness, enabling robust identification of liganded proteins. In this study, 80 reactive fragments were screened in two cell lines identifying >400 ligand-protein interactions. Hits were validated through concentration-response experiments and the platform was utilised for hit expansion and live cell experiments. This label-free platform represents a significant step forward in high-throughput proteomics to evaluate ligandability of cysteines across the human proteome.
Additional file 1 of Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes
Creators: name: Saigusa, Taro
name: Watanabe, Kentaro
name: Hada, Yurika
name: Ishii, Kota
name: Kameda, Wataru
name: Susa, Shinji
name: Ishizawa, Kenichi
name: Ishihara, Hisamitsu
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1. Supplemental figure. Mean IMT of groups in combination high or low CAVI or baPWV groups with high or low eGFR after adjustment by propensity score matching. A: combination CAVI with eGFR, B: combination baPWV with eGFR. CAVI; cardio-ankle vascular index, baPWV; brachial-ankle pulse wave velocity, IMT; intima-media thickness, eGFR; estimated glomerular filtration rate. **P < 0.01 vs group with low CAVI and high eGFR.
Proceedings of the 2024 Centre for Information Technology in Education Research Symposium (CITERS)
Creators: name: CITE
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 460299
subject: Artificial intelligence not elsewhere classified
classificationCode: 390405
subject: Educational technology and computing
classificationCode: 460804
subject: Computing education
classificationCode: 390307
subject: Teacher education and professional development of educators

description: 2024 Centre for Information Technology in Education Research Symposium (CITERS)Date: 2024.5.3-4; Location: The University of Hong Kong, Hong Kong, China; Website: https://citers2024.cite.hku.hk/Publication of Centre for Information Technology in Education (CITE)

DOI: https://doi.org/10.6084/m9.figshare.28142273
Additional file 2 of Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes
Creators: name: Saigusa, Taro
name: Watanabe, Kentaro
name: Hada, Yurika
name: Ishii, Kota
name: Kameda, Wataru
name: Susa, Shinji
name: Ishizawa, Kenichi
name: Ishihara, Hisamitsu
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 2. Supplemental Table S1. Prediction score sheet for Suita score. Supplemental Table S2. Comparison of variation in CAVI and baPWV in each age groups or all subjects.
Proceedings of the 2024 Centre for Information Technology in Education Research Symposium (CITERS)
Creators: name: HKU
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 460299
subject: Artificial intelligence not elsewhere classified
classificationCode: 390405
subject: Educational technology and computing
classificationCode: 460804
subject: Computing education
classificationCode: 390307
subject: Teacher education and professional development of educators

description: 2024 Centre for Information Technology in Education Research Symposium (CITERS)Date: 2024.5.3-4; Location: The University of Hong Kong, Hong Kong, China; Website: https://citers2024.cite.hku.hk/Publication of Centre for Information Technology in Education (CITE)

DOI: https://doi.org/10.6084/m9.figshare.28142273
Comparing Predictive Accuracy in the Presence of a Loss Function Shape Parameter*
Creators: name: Barendse, Sander
name: Patton, Andrew
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We develop tests for out-of-sample forecast comparisons based on loss functions that contain shape parameters. Examples include comparisons using average utility across a range of values for the level of risk aversion, comparisons of forecast accuracy using characteristics of a portfolio return across a range of values for the portfolio weight vector, and comparisons using recently-proposed “Murphy diagrams” for classes of consistent scoring rules. An extensive Monte Carlo study verifies that our tests have good size and power properties in realistic sample sizes, particularly when compared with existing methods which break down when then number of values considered for the shape parameter grows. We present three empirical illustrations of the new test.
Testing for common trends in non-stationary large datasets*
Creators: name: Barigozzi, Matteo
name: Trapani, Lorenzo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We propose a testing based procedure to determine the number of common trends in a large non-stationary dataset. Our procedure is based on a factor representation, where we determine whether there are (and how many) common factors (i) with linear trends, and (ii) with stochastic trends. Cointegration among the factors is also permitted. Our analysis is based on the fact that those largest eigenvalues of a suitably scaled covariance matrix of the data corresponding to the common factor part diverge, as the dimension N of the dataset diverges, whilst the others stay bounded. Therefore, we propose a class of randomised test statistics for the null that the p-th largest eigenvalue diverges, based directly on the estimated eigenvalue. The tests only requires minimal assumptions on the data generating process. Monte Carlo evidence shows that our procedure has very good finite sample properties, clearly dominating competing approaches when no common trends are present. We illustrate our methodology through an application to US bond yields with different maturities observed over the last 30 years.
Additional file 1 of Caregiver’s burden at the end of life of their loved one: insights from a longitudinal qualitative study among working family caregivers
Creators: name: Bijnsdorp, Femmy M.
name: Onwuteaka-Philipsen, Bregje D.
name: Boot, Cécile R. L.
name: van der Beek, Allard J.
name: Pasman, H. Roeline W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. COREQ checklist. Consolidated criteria for reporting qualitative research (COREQ): 32-item checklist.
Evaluating the performance of gaze interaction for map target selection
Creators: name: Zhang, Changbo
name: Liao, Hua
name: Meng, Jinhua
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: The eye tracking approach has the potential to facilitate more tailored and intelligent geoapplication interactions. There is a lack of knowledge regarding how gaze interaction influences user performance (accuracy and efficiency), visual behavior, and cognitive workload in real-world map-reading settings. In this study, we adopted a low-cost eye tracker and dwell time method to implement a fundamental gaze-based map interaction: target (point, line and area) selection. We administered a comparative experiment in which 36 participants were asked to perform a series of map target selection tasks using gaze-based and mouse interactions. The results demonstrated that gaze-based map interaction is comparable to mouse in terms of overall efficiency. By evaluating the visual behavior of the participants, we found that mouse interaction exhibited heightened fixation frequency and larger saccade amplitude than gaze interaction. Although gaze-based map interaction frustrated participants more often, the overall cognitive workload was no different from that of mouse interaction. These differences between interaction modes were largely affected by task types but rarely dependent on target shapes or positions. Moreover, participants evaluated gaze interaction higher in terms of attractiveness, stimulation and novelty. These results are beneficial for map interaction researchers and developers.
Additional file 2 of Caregiver’s burden at the end of life of their loved one: insights from a longitudinal qualitative study among working family caregivers
Creators: name: Bijnsdorp, Femmy M.
name: Onwuteaka-Philipsen, Bregje D.
name: Boot, Cécile R. L.
name: van der Beek, Allard J.
name: Pasman, H. Roeline W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Criteria for methodological rigor. Criteria for methodological rigor in qualitative studies and applied strategies.
Additional file 1 of Development of indicators to assess quality and patient pathways in interdisciplinary care for patients with 14 ambulatory-care-sensitive conditions in Germany
Creators: name: Schüttig, Wiebke
name: Flemming, Ronja
name: Mosler, Christiane Höhling
name: Leve, Verena
name: Reddemann, Olaf
name: Schultz, Annemarie
name: Brua, Emmanuelle
name: Brittner, Matthias
name: Meyer, Frank
name: Pollmanns, Johannes
name: Martin, Johnannes
name: Czihal, Thomas
name: von Stillfried, Dominik
name: Wilm, Stefan
name: Sundmacher, Leonie
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
title: Sperngel’s deformity: about three cases.
title: La déformation de Sperngel: à propos de 3 cas.
Creators: name: En-Nafaa, Issam
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2018
Subjects: Surélévation congénitale ; Scapula; déformation de Sprengel ; imagerie

description: The congenital elevation of the scapula or Sprengel’s deformity is a very rare congenital malformation, characterized by an elevated dysmorphic scapula.
It is result of insuffient caudal migration of the scapula during the embryonic period and is manifested from an early age by aesthetic and functional abnormalities.
Imaging makes it possible to make the positive diagnosis of this congenital malformation, to look for the associated malformations, especially of the omo-vertebral bone, thus allowing an adequate management.
We report three cases of congenital elevation of scapula diagnosed at imaging.
description: La surélévation congénitale de la scapula ou déformation de Sprengel est une malformation congénitale très rare, caractérisée par une ascension de l’omoplate qui est plus au moins dysmorphique. Elle est due à un défaut de migration caudale de l’omoplate au cours de la vie embryonnaire et se manifeste depuis le bas âge par des anomalies esthétiques avec une ascension de l’omoplate et des anomalies fonctionnelles.
L’imagerie permet de faire le diagnostic positif de cette malformation congénitale, de rechercher les malformations associées surtout de l’os omo-vertébral, permettant ainsi une prise en charge adéquate.
Nous rapportons trois observations de surélévation congénitale de l’omoplate dont le diagnostic a été posé à l’imagerie.
Additional file 1 of Correlates and determinants of transport-related physical activity among adults: an interdisciplinary systematic review
Creators: name: Evans, Jack T.
name: Phan, Hoang
name: Buscot, Marie-Jeanne
name: Gall, Seana
name: Cleland, Verity
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Additional file 1. Modified Newcastle-Ottawa quality assessment scale. Modified Newcastle-Ottawa Scale used in the assessment of article quality.
Stochastische Simulation großflächiger, hochwasserrelevanter Niederschlagsereignisse
Creators: name: Ehmele, Florian Tim
Publisher: name: KIT Scientific Publishing
Year: 2018
Subjects: Niederschlag
Stochastik
Hochwasser
Meteorologie
Simulation
meteorology
precipitation
simulation
stochastic
flood risk

description: Die Bestimmung von Wahrscheinlichkeiten für Niederschlagsereignisse mit hoher Wiederkehrperiode ist wegen der kurzen Zeitspanne, in der Messdaten verfügbar sind, schwierig. Auch eine homogene Abdeckung durch Messstationen insbesondere in Gebirgen ist nur schwer realisierbar. In dieser Arbeit wird ein räumlich hoch aufgelöstes, analytisches Modell zur stochastischen Simulation von Starkniederschlägen in Verbindung mit großräumigen Flusshochwassern entwickelt, evaluiert und angewendet.
Additional file 3 of Correlates and determinants of transport-related physical activity among adults: an interdisciplinary systematic review
Creators: name: Evans, Jack T.
name: Phan, Hoang
name: Buscot, Marie-Jeanne
name: Gall, Seana
name: Cleland, Verity
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Additional file 3. Sample size distributions. Sample size distribution for TRPA’s relationship with age and sex.
Additional file 1 of HPV genotyping by L1 amplicon sequencing of archived invasive cervical cancer samples: a pilot study
Creators: name: Warden, Charles D.
name: Cholli, Preetam
name: Qin, Hanjun
name: Guo, Chao
name: Wang, Yafan
name: Kancharla, Chetan
name: Russell, Angelique M.
name: Salvatierra, Sylvana
name: Mutsvunguma, Lorraine Z.
name: Higa, Kerin K.
name: Wu, Xiwei
name: Wilczynski, Sharon
name: Pillai, Raju
name: Ogembo, Javier Gordon
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 1. Reference sequences used for HPV genotyping.
Realized Quantiles*
Creators: name: Dimitriadis, Timo
name: Halbleib, Roxana
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Statistics

description: This article proposes a simple approach to estimate quantiles of daily financial returns directly from high-frequency data. We denote the resulting estimator as realized quantile (RQ) and use it to forecast tail risk measures, such as Value at Risk (VaR) and Expected Shortfall (ES). The RQ estimator is built on the assumption that financial logarithm prices are subordinated self-similar processes in intrinsic time. The intrinsic time dimension stochastically transforms the clock time in order to capture the real “heartbeat” of financial markets in accordance with their trading activity and/or riskiness. The self-similarity assumption allows to compute daily quantiles by simply scaling up their intraday counterparts, while the subordination technique can easily accommodate numerous empirical features of financial returns, such as volatility persistence and fat-tailedness. Our method, which is built on a flexible assumption, is simple to implement and exploits the rich information content of high-frequency data from another time perspective than the classical clock time. In a comprehensive empirical exercise, we show that our forecasts of VaR and ES are more accurate than the ones from a large set of up-to-date comparative models, for both, stocks and foreign exchange rates.
Additional file 3 of HPV genotyping by L1 amplicon sequencing of archived invasive cervical cancer samples: a pilot study
Creators: name: Warden, Charles D.
name: Cholli, Preetam
name: Qin, Hanjun
name: Guo, Chao
name: Wang, Yafan
name: Kancharla, Chetan
name: Russell, Angelique M.
name: Salvatierra, Sylvana
name: Mutsvunguma, Lorraine Z.
name: Higa, Kerin K.
name: Wu, Xiwei
name: Wilczynski, Sharon
name: Pillai, Raju
name: Ogembo, Javier Gordon
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 3. Effect of varying read thresholds for detecting HPV58 and HPV co-infections.
Additional file 4 of HPV genotyping by L1 amplicon sequencing of archived invasive cervical cancer samples: a pilot study
Creators: name: Warden, Charles D.
name: Cholli, Preetam
name: Qin, Hanjun
name: Guo, Chao
name: Wang, Yafan
name: Kancharla, Chetan
name: Russell, Angelique M.
name: Salvatierra, Sylvana
name: Mutsvunguma, Lorraine Z.
name: Higa, Kerin K.
name: Wu, Xiwei
name: Wilczynski, Sharon
name: Pillai, Raju
name: Ogembo, Javier Gordon
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 4. Effect of varying off-target human read thresholds on HPV genotype.
High-Dimensional Interaction Detection With False Sign Rate Control
Creators: name: Li, Daoji
name: Kong, Yinfei
name: Fan, Yingying
name: Lv, Jinchi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Identifying interaction effects is fundamentally important in many scientific discoveries and contemporary applications, but it is challenging since the number of pairwise interactions increases quadratically with the number of covariates and that of higher-order interactions grows even faster. Although there is a growing literature on interaction detection, little work has been done on the prediction and false sign rate on interaction detection in ultrahigh-dimensional regression models. This article fills such a gap. More specifically, in this article we establish some theoretical results on interaction selection for ultrahigh-dimensional quadratic regression models under random designs. We prove that the examined method enjoys the same oracle inequalities as the lasso estimator and further admits an explicit bound on the false sign rate. Moreover, the false sign rate can be asymptotically vanishing. These new theoretical characterizations are confirmed by simulation studies. The performance of our proposed approach is further illustrated through a real data application.