cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design and synthesis of 6-amino-quinoxaline-alkynyl as potential aromatase (CYP19A1) inhibitors.
Creators: name: Lekgau, Karabo
name: Raphoko, Lerato A.
name: Lebepe, Charity M.
name: Mongokoana, Dikgale F.
name: Leboho, Tlabo C.
name: Matsebatlela, Thabe M.
name: Gumede, Njabulo J.
name: Nxumalo, Winston
Publisher: name: Mangosuthu University of Technology (MUT)
Year: 2023
Subjects: Cancer cell biology
Cancer genetics
Molecular medicine
Medical biochemistry - amino acids and metabolites

description: Herein we report the design and synthesis of 6-amino-quinoxaline-alkynyl derivatives, which were eval?uated for their anti-cancer properties against MCF-7 breast cancer cells. A total 11 amino-quinoxaline compounds were identified by molecular docking from a library of over 100 compounds, to be potential aromatase (CYP19A1) inhibitors. MD simulations shed more light on the equilibration and stabilities of the enzyme-ligand complexes. All identified compounds were synthesised and evaluated against breast cancer (MCF-7), with three compounds 5, 8 and 15 showing promising inhibitory activity against MCF-7 at IC50 of 69.7, 35.6 and 69.8 μM, respectively. Compounds 5 and 8 were also observed to inhibit aro?matase CYP19A with IC50 of 12.2 and 66.7 μM, respectively. The nitro-quinoxaline derivatives, which were intermediates in the synthesis of the amino-quinoxaline compounds, were found to be active against My?cobacterium tuberculosis (Mtb) H37Rv strain, with seven compounds; 18, 19, 24, 25, 27, 28 and 29, having MIC90 ranging from 0.6 to 9.5 μM.
MOESM1 of Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer
Creators: name: Grivas, Petros
name: Day, Kathleen
name: Karatsinides, Andreas
name: Paul, Alyssa
name: Shakir, Nazia
name: Owainati, Iya
name: Liebert, Monica
name: Kunju, Lakshmi
name: Thomas, Dafydd
name: Hussain, Maha
name: Day, Mark
Publisher: name: figshare
Year: 2013
Subjects: Neuroscience
Biotechnology
Cancer
Science Policy

description: Supplementary material, approximately 85.2 KB.
On Brauer $p$-dimensions and index-exponent relations over finitely-generated field extensions
Creators: name: Chipchakov, I. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 16K20, 16K50 (Primary), 12F20, 12J10, 16K40 (Secondary)

description: Let $E$ be a field of absolute Brauer dimension abrd$(E)$, and $F/E$ a transcendental finitely-generated extension. This paper shows that the Brauer dimension Brd$(F)$ is infinite, if abrd$(E) = \infty $. When the absolute Brauer $p$-dimension abrd$_{p}(E)$ is infinite, for some prime number $p$, it proves that for each pair $(n, m)$ of integers with $n \ge m > 0$, there is a central division $F$-algebra of Schur index $p ^{n}$ and exponent $p ^{m}$. Lower bounds on the Brauer $p$-dimension Brd$_{p}(F)$ are obtained in some important special cases where abrd$_{p}(E) < \infty $. These results solve negatively a problem posed by Auel et al. (Transf. Groups {\bf 16}: 219-264, 2011).
description: 19 pages, LaTeX; "coordinates" of three references updated; to appear in Manuscripta Mathematica. arXiv admin note: substantial text overlap with arXiv:1207.0965
Chinese television between propaganda and entertainment: socialist traditions, marketisation and popular TV dramas, 1992–2017
Creators: name: Yingzi Wang
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 169999 Studies in Human Society not elsewhere classified
subject: FOS: Sociology

description: China's economic reforms and opening to the world since 1978 have profoundly changed the operation and function of Chinese television. Following the accelerated market reforms from 1992, the production of Chinese TV programmes has become increasingly driven by ratings and oriented towards popular entertainment. Within this context, this project examines how Chinese television has evolved over recent decades in response to wider political, economic and cultural changes in China, with a focus on prime-time television dramas broadcast between 1992 and 2017. It situates the analysis of TV dramas within the spectrum of two poles – propaganda and entertainment, aiming to explore how these TV programmes have continued to serve the propaganda imperatives of the Party-state, while at the same time responding to audience demands regarding entertainment.In order to map the changes and continuities exemplified by Chinese TV dramas, this project has adopted a mixed-method approach. This approach includes a systematic quantitative analysis to delineate long-term trends, and four qualitative case studies to establish a more thorough understanding of the detailed transformation in Chinese television. The thesis demonstrates that while Chinese television has become increasingly driven by commercial values that prioritise audience interests and popular elements, television entertainment in China still needs to align with official ideological lines. In the meantime, varying degrees of political supervision have been identified from different levels of TV stations, and the Party-state has actively engaged in promoting its own agenda through Chinese television entertainment. These have shown an increasingly complex picture of socialist television in the new era.In these ways, this project sheds light on the interplay between political propaganda and commercial trends within the Chinese television system over the past two decades and a half. It is intended to contribute to existing studies on the relationship between propaganda and popular entertainment, and to the analyses of propaganda in television drama. It would also facilitate a systematic understanding of socialist television contexts, bridging the east-west divide on the perceptions of contemporary socialist television culture.
Quantum many-body topology of quasicrystals
Creators: name: Else, Dominic V.
name: Huang, Sheng-Jie
name: Prem, Abhinav
name: Gromov, Andrey
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this paper, we characterize quasicrystalline interacting topological phases of matter i.e., phases protected by some quasicrystalline structure. We show that the elasticity theory of quasicrystals, which accounts for both "phonon" and "phason" modes, admits non-trivial quantized topological terms with far richer structure than their crystalline counterparts. We show that these terms correspond to distinct phases of matter and also uncover intrinsically quasicrystalline phases, which have no crystalline analogues. For quasicrystals with internal $\mathrm{U}(1)$ symmetry, we discuss a number of interpretations and physical implications of the topological terms, including constraints on the mobility of dislocations in $d=2$ quasicrystals and a quasicrystalline generalization of the Lieb-Schultz-Mattis-Oshikawa-Hastings theorem. We then extend these ideas much further and address the complete classification of quasicrystalline topological phases, including systems with point-group symmetry as well as non-invertible phases. We hence obtain the "Quasicrystalline Equivalence Principle," which generalizes the classification of crystalline topological phases to the quasicrystalline setting.
description: 13 pages + 4 pages appendices. v2 Additional references
Demonstration of Shor's factoring algorithm for N=21 on IBM quantum processors
Creators: name: Skosana, Unathi
name: Tame, Mark
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report a proof-of-concept demonstration of a quantum order-finding algorithm for factoring the integer 21. Our demonstration involves the use of a compiled version of the quantum phase estimation routine, and builds upon a previous demonstration by Martín-López et al. in Nature Photonics 6, 773 (2012). We go beyond this work by using a configuration of approximate Toffoli gates with residual phase shifts, which preserves the functional correctness and allows us to achieve a complete factoring of N=21. We implemented the algorithm on IBM quantum processors using only 5 qubits and successfully verified the presence of entanglement between the control and work register qubits, which is a necessary condition for the algorithm's speedup in general. The techniques we employ may be useful in carrying out Shor's algorithm for larger integers, or other algorithms in systems with a limited number of noisy qubits.
description: 11 pages, 10 figures, appendix
New type of sand wedge polygons in the salt cemented soils of the hyper-arid Atacama Desert
Creators: name: Sager, Christof
name: Airo, Alessandro
name: Arens, Felix L.
name: Schulze-Makuch, Dirk
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 550 Geowissenschaften
subject: patterned ground
subject: sand wedge polygon
subject: Atacama Desert
subject: hyper-arid

description: Polygonal grounds are landscape features commonly associated with periglacial environments originating from freeze-thawing cycles or frost-related processes. However, such a genesis is unlikely for polygonal grounds on alluvial surfaces in the warm and hyper-arid Atacama Desert due to the lack of enduring sub-zero temperatures and limited water availability, whereas a cracking mechanism based on thermal contraction and/or desiccation is more plausible. To differentiate between those mechanisms, we performed a quantitative morphometric terrain characterization in combination with a geochemical and sedimentological analysis on three polygonal networks located in the Yungay area of the Atacama Desert, Chile. Our data show that these sand wedge polygons differ from other polygonal features in the Yungay area such as salt polygons and mud crack polygons from playa environments in regard to composition, morphometry and topographical setting. The investigated polygonal soils are composed of siliciclastic sediment that is mainly cemented by sulfates (gypsum & anhydrite) in the shallow ground (~0–50 cm) and by nitrates and chlorides in the deeper ground (~50–100 cm) while being separated by about 1 m deep, salt-poor and V-shaped sand wedges. The low clay content (~2 wt%) makes an exclusive desiccation origin less relevant whereas the high salt content (63 wt%) and the high surface temperature variations make thermal contraction origin more likely. Morphometric data indicate a link between topography and polygon geometry, as the flat-centered polygons (mean size 3.9 to 4.7 m) are aligned either in slope direction or perpendicular to it, while being more elongated on steeper slopes, which is common to thermal contraction polygons. Although we cannot exclude that desiccation cracking plays a minor role for the formation of the here described polygons, we conclude that their genesis is dominated by thermal contraction.
Additional file 1 of In Vivo Regulation of the μ Opioid Receptor: Role of the Endogenous Opioid Agents
Creators: name: Gonzalez-Nunez, Veronica
name: González, Ada Jimenez
name: Barreto-Valer, Katherine
name: Rodríguez, Raquel E.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Supplementary material, approximately 336 KB.
Renormalization group invariant of lepton Yukawa couplings
Creators: name: Tsuyuki, Takanao
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: By using quark Yukawa matrices only, we can construct renormalization invariants that are exact at the one-loop level in the standard model. One of them $I^q$ is accidentally consistent with unity, even though quark masses are strongly hierarchical. We calculate a lepton version of the invariant $I^l$ for Dirac and Majorana neutrino cases and find that $I^l$ can also be close to unity. For the Dirac neutrino and inverted hierarchy case, if the lightest neutrino mass is 3.0 meV to 8.8 meV, an equality $I^q=I^l$ can be satisfied. These invariants are not changed even if new particles couple to the standard model particles, as long as those couplings are generation independent.
description: v2: 10 pages, 3 figures, Appendix added, version published in Phys. Rev. D; v1: 8 pages 3 figures
Additional file 1 of 3D modeling of in vivo MRI-guided nano-photothermal therapy mediated by magneto-plasmonic nanohybrids
Creators: name: Tavangari, Zahed
name: Asadi, Mohammadreza
name: Irajirad, Rasoul
name: Sarikhani, Abolfazl
name: Alamzadeh, Zahra
name: Ghaznavi, Habib
name: Khoei, Samideh
Publisher: name: figshare
Year: 2023
Subjects: subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Figure S1 a Plot of the temperature vs. time for the nanohybrids (500 μg/ml Au, A808 = 3.2) during laser irradiation (808 nm, 1.4 W/cm2) and cooling (laser off) stages. (b) Plot of the cooling time vs. -Lnθ. Figure S2 In vitro cell experiments. a Viability of CT26 cells treated with nanohybrids at varying gold concentrations over 4, 12, and 24 hours. b Viabilities of CT26 cells after NPTT at different laser power densities. Error bars were based on the standard deviations of three parallel samples.
Eolian erosion of polygons in the Atacama Desert as a proxy for hyper-arid environments on Earth and beyond
Creators: name: Sager, Christof
name: Airo, Alessandro
name: Arens, Felix L.
name: Schulze-Makuch, Dirk
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 550 Geowissenschaften, Geologie
subject: Atacama Desert
subject: patterned grounds
subject: polygon
subject: hyper-arid
subject: Eolian erosion

description: Polygonal networks occur on various terrestrial and extraterrestrial surfaces holding valuable information on the pedological and climatological conditions under which they develop. However, unlike periglacial polygons that are commonly used as an environmental proxy, the information that polygons in the hyper-arid Atacama Desert can provide is little understood. To promote their use as a proxy, we investigated a polygonal network within an inactive channel that exhibits uncommonly diverse surface morphologies and mineral compositions, using geochemical and remote sensing techniques. Our findings show that the polygons belong to a continuous network of the same genetic origin. Their differences result from post-formational differential eolian erosion up to 50 cm depth, exposing indurated subsurface horizons rich in sulfate or nitrate and chloride. Their location in an ancient channel could lead to the misinterpretation of fluvial polygon erosion, however, we find no such signs but evidence for aqueous resurfacing of microtopography by fog and minimal rainwater infiltration. Our findings extend the use of polygons as proxies in the Atacama Desert, indicating saline soils and hyper-arid conditions. We conclude that this example of polygon erosion can guide future polygon research, especially regarding the use of erosional surfaces on Earth and beyond to gain valuable subsurface insights.
Non-perturbative aspects of particle acceleration in non-linear electrodynamics
Creators: name: Burton, David A.
name: Flood, Stephen P.
name: Wen, Haibao
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: We undertake an investigation of particle acceleration in the context of non-linear electrodynamics. We deduce the maximum energy that an electron can gain in a non-linear density wave in a magnetised plasma, and we show that an electron can `surf' a sufficiently intense Born-Infeld electromagnetic plane wave and be strongly accelerated by the wave. The first result is valid for a large class of physically reasonable modifications of the linear Maxwell equations, whilst the second result exploits the special mathematical structure of Born-Infeld theory.
description: 12 pages. Minor typos corrected to conform with Open Access journal version
Graph Unlearning
Creators: name: Chen, Min
name: Zhang, Zhikun
name: Wang, Tianhao
name: Backes, Michael
name: Humbert, Mathias
name: Zhang, Yang
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Cryptography and Security (cs.CR)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Machine unlearning is a process of removing the impact of some training data from the machine learning (ML) models upon receiving removal requests. While straightforward and legitimate, retraining the ML model from scratch incurs a high computational overhead. To address this issue, a number of approximate algorithms have been proposed in the domain of image and text data, among which SISA is the state-of-the-art solution. It randomly partitions the training set into multiple shards and trains a constituent model for each shard. However, directly applying SISA to the graph data can severely damage the graph structural information, and thereby the resulting ML model utility. In this paper, we propose GraphEraser, a novel machine unlearning framework tailored to graph data. Its contributions include two novel graph partition algorithms and a learning-based aggregation method. We conduct extensive experiments on five real-world graph datasets to illustrate the unlearning efficiency and model utility of GraphEraser. It achieves 2.06$\times$ (small dataset) to 35.94$\times$ (large dataset) unlearning time improvement. On the other hand, GraphEraser achieves up to $62.5\%$ higher F1 score and our proposed learning-based aggregation method achieves up to $112\%$ higher F1 score.\footnote{Our code is available at \url{https://github.com/MinChen00/Graph-Unlearning}.}
description: To Appear in 2022 ACM SIGSAC Conference on Computer and Communications Security, November 7-11, 2022. Please cite our CCS version
MOESM1 of In Vivo Regulation of the Îź Opioid Receptor: Role of the Endogenous Opioid Agents
Creators: name: Gonzalez-Nunez, Veronica
name: GonzĂĄlez, Ada
name: Barreto-Valer, Katherine
name: RodrĂ­guez, Raquel
Publisher: name: figshare
Year: 2013
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material, approximately 336 KB.
OPERAS-P Deliverable: Advocacy Guide
Creators: name: OPERAS-P Consortium
Publisher: name: Zenodo
Year: 2020
Subjects: advocacy
social sciences and humanities
community-building
open access

description: This Deliverable has been prepared by the OPERAS (Open Access in the European Research Area for Social Sciences and Humanities) Special Interest Group on Advocacy for Open Access Publishing in the Social Sciences and Humanities (Advocacy SIG) as part of T7.4 of the project OPERAS-P (Preparing open access in the European research area through scholarly communication).
N=2 Super-EYM coloured black holes from defective Lax matrices
Creators: name: Meessen, P.
name: Ortín, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct analytical supersymmetric coloured black hole solutions, i.e. non-Abelian black hole solutions that have no asymptotic non-Abelian charge but do have non-Abelian charges on the horizon that contribute to the Bekenstein-Hawking entropy, to two SU(3)-gauged N=2 d= supergravities. The analytical construction is made possible due to the fact that the main ingredient is the Bogomol'nyi equation, which under the assumption of spherical symmetry admits a Lax pair formulation. The Lax matrix needed for the coloured black holes must be defective which, even though it is the non-generic and less studied case, is a minor hindrance.
description: 20 pages, 1 figure; to be published version
Minimal SU(6) Gauge-Higgs Grand Unification
Creators: name: Angelescu, Andrei
name: Bally, Andreas
name: Blasi, Simone
name: Goertz, Florian
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a minimal viable Gauge-Higgs Grand Unification scenario in warped space based on a $SU(6)$ bulk symmetry - unifying the gauge symmetries of the SM and their breaking sector. We show how the issue of light exotic new states is eliminated by appropriately breaking the gauge symmetry on the UV and IR boundaries by either brane scalars or gauge boundary conditions. The SM fermion spectrum is naturally reproduced including Dirac neutrinos and we compute the Higgs potential at one-loop, finding easily solutions with a realistic $m_h \sim 125$ GeV. The problem of proton decay is addressed by showing that baryon number is a hidden symmetry of the model. Among the phenomenological consequences, we highlight the presence of a scalar leptoquark and a scalar singlet. The usual $X,Y$ gauge bosons from $SU(5)$ GUTs are found at collider accessible masses.
description: 7 pages, 2 figures; v2: matches PRD version
Ocena zewnętrzna w systemie szkolnictwa zawodowego - gdzie kończy się pomiar dydaktyczny a zaczyna rzeczywistość?
Creators: name: Pogorzelska, Anna
Publisher: name: Szkoła - Zawód - Praca
Year: 2011

description: Szkoła - Zawód - Praca, Nr 2 (2011): Szkoła - Zawód - Praca
Dynamical Instability and Expansion-free Condition in $f(R,T)$ Gravity
Creators: name: Noureen, Ifra
name: Zubair, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Dynamical analysis of spherically symmetric collapsing star surrounding in locally anisotropic environment with expansion-free condition is presented in $f(R,T)$ gravity, where $R$ corresponds to Ricci scalar and $T$ stands for the trace of energy momentum tensor. The modified field equations and evolution equations are reconstructed in the framework of $f(R,T)$ gravty. In order to acquire the collapse equation we implement the perturbation on all matter variables and dark source components comprising the viable $f(R,T)$ model. The instability range is described in Newtonian and post-Newtonian eras by constraining the adiabatic index $Γ$ to maintain viability of considered model and stable stellar configuration.
description: 22 pages
MPEC 2023-R13 : DAILY ORBIT UPDATE (2023 September 5)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
A Bottom-Up Approach to Lepton Flavor and CP Symmetries
Creators: name: Everett, Lisa L.
name: Garon, Todd
name: Stuart, Alexander J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We perform a model-independent analysis of the possible residual Klein and generalized CP symmetries associated with arbitrary lepton mixing angles in the case that there are three light Majorana neutrino species. This approach emphasizes the unique role of the Majorana phases and provides a useful framework in which to discuss the origin of the Dirac CP phase in scenarios with spontaneously broken flavor and generalized CP symmetries. The method is shown to reproduce known examples in the literature based on tribimaximal and bitrimaximal mixing patterns, and is used to investigate these issues for the case of a particular (GR1) golden ratio mixing pattern.
description: 18 pages, references added, minor typos corrected, matches version published in JHEP
Pedagogika zawodowego rozwoju człowieka. Syntetycznie ujęta propozycja
Creators: name: Czarnecki, Kazimierz M.
Publisher: name: Szkoła - Zawód - Praca
Year: 2011

description: Szkoła - Zawód - Praca, Nr 2 (2011): Szkoła - Zawód - Praca
Rozwój technologii w ustawicznej edukacji zawodowej w kontekście doświadczeń kształcenia modułowego
Creators: name: Kramek, Zbigniew
Publisher: name: Szkoła - Zawód - Praca
Year: 2011

description: Szkoła - Zawód - Praca, Nr 2 (2011): Szkoła - Zawód - Praca
Additional file 1 of Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence
Creators: name: Sutton, Lesley-Ann
name: Kostareli, Efterpi
name: Stalika, Evangelia
name: Tsaftaris, Athanasios
name: Anagnostopoulos, Achilles
name: Darzentas, Nikos
name: Rosenquist, Richard
name: Stamatopoulos, Kostas
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material, approximately 3.03 MB.
Focus Point in Dark Matter Selected High-Scale Supersymmetry
Creators: name: Zheng, Sibo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this paper, we explore conditions for focus point in the high-scale supersymmetry with the weak-scale gaugino masses. In this context the tension between the naturalness and LHC 2013 data about supersymmetry as well as the cold dark matter candidate are addressed simultaneously. It is shown that the observed Higgs mass can be satisfied in a wide classes of new models, which are realized by employing the non-minimal gauge mediation.
description: Erratum, Replacement of published version
Chern-Simons Invariants from Ensemble Averages
Creators: name: Ashwinkumar, Meer
name: Dodelson, Matthew
name: Kidambi, Abhiram
name: Leedom, Jacob M.
name: Yamazaki, Masahito
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Number Theory (math.NT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We discuss ensemble averages of two-dimensional conformal field theories associated with an arbitrary indefinite lattice with integral quadratic form $Q$. We provide evidence that the holographic dual after the ensemble average is the three-dimensional Abelian Chern-Simons theory with kinetic term determined by $Q$. The resulting partition function can be written as a modular form, expressed as a sum over the partition functions of Chern-Simons theories on lens spaces. For odd lattices, the dual bulk theory is a spin Chern-Simons theory, and we identify several novel phenomena in this case. We also discuss the holographic duality prior to averaging in terms of Maxwell-Chern-Simons theories.
description: 38 pages, 1 figure
An almost flat manifold with a cyclic or quaternionic holonomy group bounds
Creators: name: Davis, James F.
name: Fang, Fuquan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Topology (math.AT)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: A long-standing conjecture of Farrell and Zdravkovska and independently S.~T.~Yau states that every almost flat manifold is the boundary of a compact manifold. This paper gives a simple proof of this conjecture when the holonomy group is cyclic or quaternionic. The proof is based on the interaction between flat bundles and involutions.
description: 8 pages, to appear in the Journal of Differential Geometry. New version of Lemma 2.5: A manifold bounds if there is an involution on TM whose fixed bundle is full rank
A Study into patient similarity through representation learning from medical records
Creators: name: Memarzadeh, Hoda
name: Ghadiri, Nasser
name: Samwald, Matthias
name: Shahreza, Maryam Lotfi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Information Retrieval (cs.IR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: H.1; J.3
subject: 68P20

description: Patient similarity assessment, which identifies patients similar to a given patient, can help improve medical care. The assessment can be performed using Electronic Medical Records (EMRs). Patient similarity measurement requires converting heterogeneous EMRs into comparable formats to calculate their distance. While versatile document representation learning methods have been developed in recent years, it is still unclear how complex EMR data should be processed to create the most useful patient representations. This study presents a new data representation method for EMRs that takes the information in clinical narratives into account. To address the limitations of previous approaches in handling complex parts of EMR data, an unsupervised method is proposed for building a patient representation, which integrates unstructured data with structured data extracted from patients' EMRs. In order to model the extracted data, we employed a tree structure that captures the temporal relations of multiple medical events from EMR. We processed clinical notes to extract symptoms, signs, and diseases using different tools such as medspaCy, MetaMap, and scispaCy and mapped entities to the Unified Medical Language System (UMLS). After creating a tree data structure, we utilized two novel relabeling methods for the non-leaf nodes of the tree to capture two temporal aspects of the extracted events. By traversing the tree, we generated a sequence that could create an embedding vector for each patient. The comprehensive evaluation of the proposed method for patient similarity and mortality prediction tasks demonstrated that our proposed model leads to lower mean squared error (MSE), higher precision, and normalized discounted cumulative gain (NDCG) relative to baselines.
The Canonical Amoebot Model: Algorithms and Concurrency Control
Creators: name: Daymude, Joshua J.
name: Richa, Andréa W.
name: Scheideler, Christian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Emerging Technologies (cs.ET)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: The amoebot model abstracts active programmable matter as a collection of simple computational elements called amoebots that interact locally to collectively achieve tasks of coordination and movement. Since its introduction at SPAA 2014, a growing body of literature has adapted its assumptions for a variety of problems; however, without a standardized hierarchy of assumptions, precise systematic comparison of results under the amoebot model is difficult. We propose the canonical amoebot model, an updated formalization that distinguishes between core model features and families of assumption variants. A key improvement addressed by the canonical amoebot model is concurrency. Much of the existing literature implicitly assumes amoebot actions are isolated and reliable, reducing analysis to the sequential setting where at most one amoebot is active at a time. However, real programmable matter systems are concurrent. The canonical amoebot model formalizes all amoebot communication as message passing, leveraging adversarial activation models of concurrent executions. Under this granular treatment of time, we take two complementary approaches to concurrent algorithm design. We first establish a set of sufficient conditions for algorithm correctness under any concurrent execution, embedding concurrency control directly in algorithm design. We then present a concurrency control framework that uses locks to convert amoebot algorithms that terminate in the sequential setting and satisfy certain conventions into algorithms that exhibit equivalent behavior in the concurrent setting. As a case study, we demonstrate both approaches using a simple algorithm for hexagon formation. Together, the canonical amoebot model and these complementary approaches to concurrent algorithm design open new directions for distributed computing research on programmable matter.
description: 48 pages, 7 figures, 2 tables
Additional file 1 of Loss-of-Function Ferrochelatase and Gain-of-Function Erythroid-Specific 5-Aminolevulinate Synthase Mutations Causing Erythropoietic Protoporphyria and X-Linked Protoporphyria in North American Patients Reveal Novel Mutations and a High Prevalence of X-Linked Protoporphyria
Creators: name: Balwani, Manisha
name: Doheny, Dana
name: Bishop, David F.
name: Nazarenko, Irina
name: Yasuda, Makiko
name: Dailey, Harry A.
name: Anderson, Karl E.
name: Bissell, D. Montgomery
name: Bloomer, Joseph
name: Bonkovsky, Herbert L.
name: Phillips, John D.
name: Liu, Lawrence
name: Desnick, Robert J.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary material, approximately 353 KB.
Emergency Medical Services Care and Sepsis Trajectories
Creators: name: Liu, Robert
name: Ninad S. Chaudhary
name: Yealy, Donald M.
name: Huang, David T.
name: Wang, Henry E.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Objective: Many sepsis patients receive initial care from prehospital Emergency Medical Services (EMS). While earlier sepsis care improves outcomes, the characteristics, care and outcomes of those treated by EMS versus those arriving directly to an emergency department (ED) are currently not detailed. We sought to determine differences in hospital presentation, course and outcomes between EMS and non-EMS patients enrolled in the Protocolized Care of Early Septic Shock (ProCESS) trial. Methods: We performed a secondary analysis of ProCESS, which studied ED patients with septic shock. EMS care was the primary exposure. We determined differences in demographics, clinical features, interventions and hospital course between EMS and non-EMS patients. Using mixed models, we determined the association between EMS care and 60-day mortality. Results: Among 1,341 patients, 826 (61.6%) received initial EMS care. EMS patients were older, more likely to be black (OR 1.49, 95% CI 1.14–1.95) or nursing home residents (5.57, 3.61–8.60), and more likely to have chronic respiratory disease (1.36, 1.04–1.78), cerebral vascular disease (1.56; 1.04–2.33), peripheral vascular disease (2.02; 1.29–3.16), and dementia (3.53; 2.04–6.10). EMS patients were more likely to present with coma (4.48; 2.53–7.96) or elevated lactate (1.30; 1.04–1.63), and to receive mechanical ventilation in the ED (7.16; 4.34–11.79). There were no differences in infection source or total intravenous fluids. Initial differences in vasopressor use (1.66; 1.22–2.26) resolved at 6 hours (1.18; 0.94–1.47). Initial differences in APACHE II (EMS 21.8 vs. non-EMS 19.0) narrowed by 48 hours (17.9 vs. 16.3, [EMS X time] interaction p = 0.003). Although EMS patients exhibited higher 60-day mortality, after adjustment for confounders, this association was not significant (1.09, 95% CI: 0.78–1.55). Conclusions: While EMS sepsis patients presented with worse chronic, nonmodifiable characteristics and higher acuity than non-EMS patients, differences in acuity narrowed after initial hospital care. Despite having higher illness burden, EMS patients did not have worse adjusted short-term mortality.
MOESM1 of Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence
Creators: name: Sutton, Lesley-Ann
name: Kostareli, Efterpi
name: Stalika, Evangelia
name: Tsaftaris, Athanasios
name: Anagnostopoulos, Achilles
name: Darzentas, Nikos
name: Rosenquist, Richard
name: Stamatopoulos, Kostas
Publisher: name: figshare
Year: 2013
Subjects: subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material, approximately 3.03 MB.
Nanoparticles Used in Drug Delivery and Targeting: Understanding the Relationships Between Nanoparticle Quality and Interaction With Platelets
Creators: name: Bakhaidar, Rana
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering
subject: Pharmacology

description: Particles at nanoscale levels have a potential for interacting at molecular and cellular levels. The expansion of nanotechnology, for drug delivery applications, has posed questions regarding their safety profile. Such issues are associated with the small size ranges, and the presentation of surfaces with unique physicochemical properties. To date, the effects of the interaction of nanoparticles (NPs) with blood constituents, in particular, platelets remain unclear. In this study, the effects of the biodegradable PLGA-PEG NPs’ interactions with platelets were explored. NPs were formulated by a nanoprecipitation technique. A design of experiments approach was applied to investigate and model the interactive effect of pivotal formulation variables on the physical properties of NPs. NPs of 100 - 600 nm average diameters were produced, with variable degrees of monodispersity and zeta potential values. Regression analysis proved that polymer concentration was the key factor governing NP size and aggregation. The nanoformulations were dried using spray drying and freeze drying. The latter was seemingly a more efficient tool in the recovery of NPs. Morphological characterisation of dry NPs, using scanning electron microscopy, revealed spherical NPs. Through thermal analysis, the moisture-free NPs seemed of similar thermal properties to the unprocessed polymer. Stability studies of NPs suggest a reasonable preservation of PS over 14 days. The achievement of producing NPs of different sizes allowed for exploring the influence of PS on platelets. Changes in platelet function were examined using light transmission aggregometry, flow cytometry, and confocal microscopy. The NPs interfered with normal platelet aggregation profile in a size- and concentration-dependent manner. Also, washed platelet activation was enhanced with the smallest investigated NPs. Importantly, NPs bound to platelets, in both their resting and stimulated states. This thesis presents data that contributes to a greater understanding of the haematocompatibility of engineered PLGA-PEG NPs in relation to platelets. It highlights the possibility that at specific concentrations and sizes, they might present potential vehicles for therapeutics targeted to platelets, for the clinical management of cardiovascular diseases.
On the strong coupling scale in Higgs G-inflation
Creators: name: Kamada, Kohei
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Higgs G-inflation is an inflation model that takes advantage of a Galileon-like derivative coupling. It is a non-renormalizable operator and is strongly coupled at high energy scales. Perturbative analysis does not have a predictive power any longer there. In general, when the Lagrangian is expanded around the vacuum, the strong coupling scale is identified as the mass scale that appears in non-renormalizable operators. In inflationary models, however, the identification of the strong coupling scale is subtle, since the structures of the kinetic term as well as the interaction itself can be modified by the background inflationary dynamics. Therefore, the strong coupling scale depends on the background. In this letter, we evaluate the strong coupling scale of the fluctuations around the background in the Higgs G-inflation including the Nambu-Goldstone modes associated with the symmetry breaking. We find that the system is sufficiently weakly coupled when the scales which we now observe exit the horizon during inflation and the observational predictions with the semiclassical treatment are valid. However, we also find that the inflaton field value at which the strong coupling scale and the Hubble scale meet is less than the Planck scale. Therefore, we cannot describe the model from the Planck scale, or the chaotic initial condition.
description: 8 pages; v2: typos corrected, references added, matches version published in PLB
Linear tracking MPC for nonlinear systems Part I: The model-based case
Creators: name: Berberich, Julian
name: Köhler, Johannes
name: Müller, Matthias A.
name: Allgöwer, Frank
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We develop a tracking model predictive control (MPC) scheme for nonlinear systems using the linearized dynamics at the current state as a prediction model. Under reasonable assumptions on the linearized dynamics, we prove that the proposed MPC scheme exponentially stabilizes the optimal reachable equilibrium w.r.t. a desired target setpoint. Our theoretical results rely on the fact that, close to the steady-state manifold, the prediction error of the linearization is small and hence, we can slide along the steady-state manifold towards the optimal reachable equilibrium. The closed-loop stability properties mainly depend on a cost matrix which allows us to trade off performance, robustness, and the size of the region of attraction. In an application to a nonlinear continuous stirred tank reactor, we show that the scheme, which only requires solving a convex quadratic program online, has comparable performance to a nonlinear MPC scheme while being computationally significantly more efficient. Further, our results provide the basis for controlling nonlinear systems based on data-dependent linear prediction models, which we explore in our companion paper.
Linear tracking MPC for nonlinear systems Part II: The data-driven case
Creators: name: Berberich, Julian
name: Köhler, Johannes
name: Müller, Matthias A.
name: Allgöwer, Frank
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We present a novel data-driven model predictive control (MPC) approach to control unknown nonlinear systems using only measured input-output data with closed-loop stability guarantees. Our scheme relies on the data-driven system parametrization provided by the Fundamental Lemma of Willems et al. We use new input-output measurements online to update the data, exploiting local linear approximations of the underlying system. We prove that our MPC scheme, which only requires solving strictly convex quadratic programs online, ensures that the closed loop (practically) converges to the (unknown) optimal reachable equilibrium that tracks a desired output reference while satisfying polytopic input constraints. As intermediate results of independent interest, we extend the Fundamental Lemma to affine systems and we derive novel robustness bounds w.r.t. noisy data for the open-loop optimal control problem, which are directly transferable to other data-driven MPC schemes in the literature. The applicability of our approach is illustrated with a numerical application to a continuous stirred tank reactor.
Advancing the Use of Ethics in Community-Based Commercial Drug Formulary Decision-Making: A Critical Analysis Focused on Pharmacy Benefits Coverage Provided by Large Employers in the U.S. Healthcare System
Creators: name: Bentley, Roy
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: subject: 220199 Applied Ethics not elsewhere classified
subject: FOS: Philosophy, ethics and religion
subject: 111503 Clinical Pharmacy and Pharmacy Practice
subject: FOS: Clinical medicine

description: This thesis answers the two-part question: (1) What are the perspectives of the core decision-makers (employer benefit design decision-makers, managed care P&T committee members) and affected end-users (community practicing physicians, community retail pharmacists, employees (insured members)) as it relates to community-based commercial drug formulary decision-making?, and (2) What are the ethical implications of these identified perspectives? The research focused on large employers in the U.S. healthcare system providing pharmacy benefits coverage to their employees. Despite the extensive use of formularies by managed care in the U.S., there is a lack of research on this topic specific to the perspectives of the stakeholders included in this thesis and the implications of their perspectives as it relates to normative ethical theories of utilitarianism, deontology, virtue ethics and principles of biomedical ethics, namely autonomy, beneficence, maleficence and justice. The PhD Researcher conducted 1:1 blinded interviews with 10 study participants from each stakeholder group included in this thesis (n=40) with the exception of the employees (insured members) who participated in one of two focus groups (n=5; n=6). Research methods associated with Grounded Theory were applied to the interview and focus group transcripts to develop initial codes, focused codes and categories. A literature review was completed on relevant ethical theories and principles as well as the U.S. healthcare system. Based on findings of the research completed, ethics is not considered in community-based commercial drug formulary decision-making and implementation. Four categories emerged from analysis of the research: (1) Access to Rx Medications is impacted by the Financials, (2) Drug Formularies are a Means to an End, (3) Informed Decision-making is Essential to Understanding Implications of Choice, and (4) Population vs Patient-level Care is not Necessarily Reconcilable. A three-step approach is proposed to integrate ethics into the commercial drug formulary decision-making process.