cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cell stiffening is a label-free indicator of reactive oxygen species-induced intracellular acidification
Creators: name: Komaragiri, Yesaswini
name: Pires, Ricardo Hugo
name: Spiegle, Stefanie
name: Dau, Huy Tung
name: Biedenweg, Doreen
name: Ortegón Salas, Clara
name: Hossain, Md. Faruq
name: Fregin, Bob
name: Gross, Stefan
name: Gellert, Manuela
name: Lendeckel, Uwe
name: Lillig, Christopher Horst
name: Otto, Oliver
Publisher: name: Zenodo
Year: 2024

description: The files contains the raw data files of the data presented in the following manuscript, "Cell stiffening is a label-free indicator of reactivee oxygeen species-induced intracellular acidification". The files are arranged according to the figures.

Fig.1b and c.zip- This folder contain .rtdc file format. The data can be read by shapeOut and ShapeOut2 softwares which can be downloaded from https://www.zellmechanik.com/Download.html. 

Fig.1d. exponential fit.zip contains the files with format .opju  which can be read by origin.   

Fig.2- WB and 2D-rawdata.zip- This folder contains the blot images of 1D western blots which can be analysed by using imagej or fiji. The file also contain the 2D diagonal blot images in .svg format, .scn files of the blots which can be opened using image studio.

Fig.S10.data Intensity and position-rawdata and rscripts.zip- This folder contain the raw data and r-scripts used to analyse the intensity and position of F-actin and microtubule

Fig.3a and c-pH-raw-data.zip- This folder contain .fcs and data analysis of pH curve. 

Fig.3b-pH calibration curve-data.zip- This folder contain .rtdc files.

Fig.4a and b-Lysotracker and AO staining.zip- This folder contain the raw data in .czi and image files in .tif  format.

Fig.4c- viscosity -dRT-DC data.zip- This folder contain raw data for dRT-DC files in .csv, ,text, .tdms and .tsv file formats

Fig.5a-HL60 derived neutrophils- This folder contain .rtdc files.

Fig.5b-RTDC-Primary neutrophils.zip- This folder contain .rtdc files.

Fig.5b-RTDC-Jurkat.zip- This folder contain .rtdc files.

Fig.5- other cell models-pH analysis.zip-.text files.
Additional file 1: of First report of V1016G and S989P knockdown resistant (kdr) mutations in pyrethroid-resistant Sri Lankan Aedes aegypti mosquitoes
Creators: name: Sachini Fernando
name: Menaka Hapugoda
name: Rushika Perera
name: Saavedra-Rodriguez, Karla
name: Black, William
name: Nissanka De Silva
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: Table S1. Genotypes obtained for the individual samples. (DOCX 23 kb)
WALLALIS cruise,Alis R/V
Creators: name: Valérie, ALLAIN
name: MENKES Christophe
Publisher: name: Sismer
Year: 2018

description: Etude des conditions océanographiques structurant le micronecton et le zooplancton dans la zone économique exclusive inexplorée de Wallis et Futuna.Notre projet porte sur l'étude des niveaux trophiques intermédiaires de l'écosystème pélagique : le zooplancton et le micronecton. En s'appuyant à la fois sur des observations, de l'instrumentation et de la modélisation, notre projet s'intéresse à la réponse des organismes vivants aux forçages physiques et chimiques de l'environnement. Nous cherchons à mieux comprendre les mécanismes structurant l'écosystème pélagique dans la zone économique de Wallis et Futuna.Le projet allie les compétences de dynamiciens, statisticiens, acousticiens, biogéochimistes, océanographes, biologistes et halieutes de plusieurs organisations de recherche, pour modéliser et analyser les observations sur les niveaux trophiques intermédiaires.En plus de la compréhension directe liées aux nouvelles observations, nous cherchons à améliorer notre compréhension de la distribution et du comportement des proies des thons en paramétrisant/validant notre modèle de proies grâce aux campagnes à la mer. Le but à plus long terme est d'améliorer notre compréhension de la distribution et du comportement des proies des thons pour mieux comprendre les relations thons - environnement dans le Pacifique.
B1MG ESHG 2023 poster - A Maturity Level Model (MLM) for the self assessment of genomic medicine practices in healthcare systems
Creators: name: Cardoso, Maria Luís
name: Lopes, Fátima
name: Costa, Alexandra
name: Santos, Osvaldo
name: Konopko, Melissa
name: Merchant, Arshiya
name: Thorogood, Adrian
name: Saunders, Gary
name: Custers, Ilse
name: Van Den Bulcke, Marc
name: Schmitt, Tugce
name: Bogicevic, Ivana
name: Cividanes, Lene
name: Spalding, Dylan
name: Smith, Maeve
name: Bale, Mark
name: Pitini, Erica
name: Villari, Paolo
name: Baccolini, Valentini
name: Balciuniene, Anzelika
name: Ambrozaityte, Laima
name: Doménech, Elena
name: Martin-Sanchez, Fernando
name: Sobrón, Francisco
name: Saiz, Maria Luisa
name: Carracedo, Angel
name: Wedell, Anna
name: Cambon-Thomsen, Anne
name: Veimer, Annika
name: Lundgren, Bettina
name: Solary, Eric
name: Birney, Ewan
name: Martins, Henrique
name: Klovins, Janis
name: Saarela, Janna
name: North, Kathryn
name: Kroese, Mark
name: Caulfield, Mark
name: Piha, Tapani
name: Scollen, Serena
name: Vicente, Astrid
Publisher: name: Zenodo
Year: 2023
Subjects: B1MG
Beyond 1 Milion Genomes
1+MG
1+ Million Genomes Initiative
MLM
Maturity Level Model

description: Genomic medicine implementation in healthcare systems can bring us one step closer to making personalised medicine a reality with major socioeconomic benefits Citizens and patients can nowadays widely benefit from genomic data analysis for accurate and timely diagnosis, effective treatments with less adverse events, and accurate profiling for disease prevention

 

Implementation of genomics in healthcare is complex, and requires adjustments in the governance, structure and organization of health services, as well as dedicated investments Implementation is also dependent on the country context

 

In the context of the 1 +Million Genomes 1 + initiative, we developed a Maturity Level Model ( for health systems to self evaluate the maturity of their genomic medicine

practices, and define a path to optimization a MLM is tool for healthcare systems to self evaluate the level of maturity of their genomic medicine practices according to a common matrix,and to define a path to optimization

 

A MLM pilot in eight European countries provided important information regarding common strengths, weaknesses and asymmetries across Europe
REGULAR SUPPRESSION OF P,T-VIOLATING NUCLEAR MATRIX ELEMENTS
Creators: name: Khriplovich, I. B.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In heavy nuclei there is a parametrical suppression, $\;\sim A^{-1/3}\;$, of T-odd, P-odd matrix elements as compared to T-even, P-odd ones.
description: 3 pages
Additional file 1: of Building school-based social capital through ‘We Act - Together for Health’ – a quasi-experimental study
Creators: name: Stjernqvist, Nanna
name: Sabinsky, Marianne
name: Morgan, Antony
name: Trolle, Ellen
name: Thyregod, Camilla
name: Maindal, Helle
name: Bonde, Ane
name: Tetens, Inge
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Dropout by groups of baseline (only) respondents compared to baseline and follow-up respondents. The table shows the statistical comparison on the individualistic characteristics and the selected outcomes between the group of children who only responded to baseline (who were lost to follow-up) and the group of children who responded to both baseline and follow-up. (PDF 21 kb)
Haliotis parva Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Lepetellida
Haliotidae
Haliotis
Haliotis parva

description: Haliotis parva [spec. nov.]
H. testa ovata, angulo inter foramina & spiram.
Habitat in O. Africano.
Haliotides praecedentes valde affines & forte omnes tantum varietates.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 780, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Formation of Relativistic Outflows in Shearing Black Hole Accretion Coronae
Creators: name: Subramanian, Prasad
name: Becker, Peter A.
name: Kazanas, Demosthenes
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We examine the possibility that the relativistic jets observed in many active galactic nuclei may be powered by the Fermi acceleration of protons in a tenuous corona above a two-temperature accretion disk. In this picture the acceleration arises as a consequence of the shearing motion of the magnetic field in the corona, which is anchored in the underlying Keplerian disk. The protons in the corona have a power-law distribution because the density there is too low for proton-proton collisions to thermalize the energy supplied via Fermi acceleration. The same shear acceleration mechanism also operates in the disk itself, however, there the density is high enough for thermalization to occur and consequently the disk protons have a Maxwellian distribution. Particle acceleration in the corona leads to the development of a pressure-driven wind that passes through a critical point and subsequently transforms into a relativistic jet at large distances from the black hole. We combine the critical conditions for the wind with the structure equations for the disk and the corona to obtain a coupled disk/corona/wind model. Using the coupled model we compute the asymptotic Lorentz factor $Γ_\infty$ of the jet as a function of the cylindrical starting radius at the base of the outflow, in the corona. Our results suggest that $Γ_\infty \lapprox 10$, which is consistent with observations of superluminal motion in blazars. We show that collisions between the jet and broad-line emission clouds can produce high-energy radiation with a luminosity sufficient to power the $γ$-rays observed from blazars. Subject headings: radiation mechanisms: non-thermal, accretion, accretion disks, acceleration of particles, gamma rays: theory
description: 50 pages, 13 figures, accepted by ApJ, 1999
Theories for multiple resonances
Creators: name: Klakow, D.
name: Weber, M.
name: Reinhard, P. -G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Two microscopic theories for multiple resonances in nuclei are compared, n-particle-hole RPA and quantized Time-Dependent Hartree-Fock (TDHF). The Lipkin-Meshkov-Glick model is used as test case. We find that quantized TDHF is superior in many respects, except for very small systems.
description: 14 Pages, 3 figures available upon request.
Biomechanical regulation of permeability in Schlemm’s canal endothelium with respect to glaucoma
Creators: name: Braakman, Sietse
Publisher: name: Imperial College London
Year: 2014

description: Glaucoma is the leading cause of irreversible blindness worldwide and is associated with elevated intraocular pressure caused by increased aqueous humor outflow resistance. The majority of outflow resistance is located near the inner wall endothelium of Schlemm’s canal (SC) where aqueous humor passes through micron-sized pores to cross the endothelium. The basal-to- apical direction of aqueous humor filtration pushes SC cells away from their supporting basement membrane, imposing large biomechanical strain on them and leading to the formation of dome- shaped cellular outpouchings known as giant vacuoles (GVs). Our overarching hypothesis is that the demanding biomechanical environment of the inner wall provides local cues that regulate pore formation and filtration across SC endothelium. Four studies examined this hypothesis. The first study demonstrated that pore density increases with biomechanical strain applied to SC cells cultured on elastomeric membranes. The second study demonstrated that inner wall pores co-localise with regions of greater filtration across the inner wall. The third study developed a fluorescent assay to investigate pore formation in cultured SC cells, and experiments using this assay indicated that glaucomatous SC cells may have impaired pore-forming ability in response to strain. The fourth study examined the cytoskeleton and three-dimensional ultrastructure of the inner wall and showed that vimentin intermediate filaments colocalize with GVs, possibly provid- ing internal support to allow inner wall cells to withstand the demanding mechanical environment of the inner wall. Taken together, these studies reveal that pore formation is a mechanosensitive process that allows the inner wall to function as a self-regulating filter by modulating its own porosity in re- sponse to local biomechanical cues arising from basal-to-apical filtration across the endothelium. This process appears altered in glaucoma, contributing to impaired pore formation and elevated outflow resistance characteristic of the disease. Pores and intermediate filaments are therefore potential targets for future glaucoma therapies.
Bipolar Jets and Orbital Dynamics of the Supersoft X-Ray Source RX J0019.8+2156
Creators: name: Becker, C. M.
name: Remillard, R. A.
name: Rappaport, S. A.
name: McClintock, J. E.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: From 1994 to 1997 we monitored the optical spectrum of RXJ0019.8+2156. This supersoft X-ray source is one of only two accreting white dwarfs in the Galaxy thought to be burning hydrogen on their surface as a consequence of a high rate of mass transfer from a binary companion. Accurate orbital ephemerides are derived from radial velocity measure- ments of HeII emission lines, which exhibit a stable velocity semi- amplitude of 71.2 +- 3.6 km/s. We report the discovery of transient, low-velocity, bipolar jets. These jets are respresented by redshifted and blueshifted pairs of emission lines with an outflow velocity of v cos(i) = 815 km/s, where i is the binary inclination angle. When present, the jet lines also exhibit an orbital modulation of 71 km/s, which indicates that the jets are oriented nearly perpendicular to the orbital plane. On most occasions, the Hline profiles are further altered by P Cygni absorption. We show that the jets and the P Cygni features have very different temporal characteristics and binary phase dependence. The jet material and the absorbing wind must therefore occupy very different geometries. Finally, the measured mass function is combined with binary evolution models to suggest a limit, i < 40 deg. A particular model invoked to explain a high rate of mass transfer requires 16 < i < 25. However, at such small inclination it is difficult to explain the large amplitude of the orbital light curve. By contrast, a simple model fit to the jet outflow lines indicates an orbital inclination angle of 35 < i < 60.
description: 49 pages, including 9 figs.; latex; aasms4.sty; revised manuscript submitted to Astrophysical Journal, May 4, 1998
Patella Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Pezizales
Patellidae
Patella

description: Patella [gen. nov.]
Animal Limax.
Testa univalvis, subconica, absque spira.
* Labiatae s. labio interno instructae.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 780, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Gravitational Wave Signals from the First Massive Black Hole Seeds
Creators: name: Hartwig, Tilman
name: Agarwal, Bhaskar
name: Regan, John A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recent numerical simulations reveal that the isothermal collapse of pristine gas in atomic cooling haloes may result in stellar binaries of supermassive stars with $M_* \gtrsim 10^4\ \mathrm{M}_{\odot}$. For the first time, we compute the in-situ merger rate for such massive black hole remnants by combining their abundance and multiplicity estimates. For black holes with initial masses in the range $10^{4-6} \ \mathrm{M}_{\odot}$ merging at redshifts $z \gtrsim 15$ our optimistic model predicts that LISA should be able to detect 0.6 mergers per year. This rate of detection can be attributed, without confusion, to the in-situ mergers of seeds from the collapse of very massive stars. Equally, in the case where LISA observes no mergers from heavy seeds at $z \gtrsim 15$ we can constrain the combined number density, multiplicity, and coalesence times of these high-redshift systems. This letter proposes gravitational wave signatures as a means to constrain theoretical models and processes that govern the abundance of massive black hole seeds in the early Universe.
description: Accepted for publication in MNRAS: Letters
Vitamin D and severe therapy resistant asthma in children
Creators: name: Gupta, Atul
Publisher: name: Imperial College London
Year: 2013

description: Background There is increasing evidence that low vitamin D levels are implicated in paediatric asthma Hypotheses Children with severe, therapy resistant (STRA) have low serum vitamin D levels which are associated with worse asthma control and airway pathology. In vitro, steroid responsiveness of peripheral blood mononuclear cells (PBMCs) from STRA is improved by vitamin D. Methods Serum 25-hydroxyvitamin D (25[OH]D3) was measured in 36 STRA, 26 mild/moderate asthmatics (MA) and 24 non-asthmatic controls, and related to asthma control and exacerbations. 22/36 children with STRA underwent bronchoscopy with assessment of airway inflammation and remodelling. The in vitro steroid responsiveness of PBMC was assessed, in the absence or presence of dexamethasone and vitamin D. Results Median 25[OH]D3 levels were significantly lower in STRA (28nmol/L) than MA (42.5nmol/L) and controls (56.5nmol/L). There were positive relationships between 25[OH]D3 levels and %predicted first second forced expired volume (r=0.4, p<0.001) and forced vital capacity (r=0.3, p=0.002). 25[OH]D3 levels were positively associated with asthma control test (ACT) (r=0.6, p<0.001) and inversely associated with exacerbations (r=-0.6, p<0.001) and inhaled steroid dose (r=-0.39, p=0.001) in asthmatics. Airway smooth muscle (ASM) mass was inversely related to 25[OH]D3 levels (r=-0.6, p<0.01). Asthmatic children had diminished levels of bronchoalveolar lavage IL-10 (p<0.001). Their PBMC also demonstrated significantly impaired capacity to secrete IL-10 in culture (p<0.001) and the inclusion of vitamin D, enhanced dexamethasone-induced IL-10 (p<0.05), production. Furthermore vitamin D status correlated with airway IL-10 (r=0.6, p<0.01) and CD4+ FoxP3 T regulatory cells (r=0.6, p<0.01). Children with STRA had significantly higher vitamin D binding protein (VDBP) levels in BAL compared to MA (p<0.05) and controls (p<0.01) and these were positively associated with symptoms (ACT) (r=0.5, p=0.01) and inhaled corticosteroid usage (r=0.6, p=0<0.01). Summary Lower serum vitamin D levels in STRA children were associated with increased ASM mass, worse asthma control, lung function and reduced BAL IL-10 and T regulatory cells. In vitro vitamin D enhanced dexamethasone-induced IL-10 production. These data suggest vitamin D supplementation may be useful in STRA and support the need for a clinical trial.
title: Die Fragilität des Körpers
title: Ein menschenwürdiges Leben durch persönliche Assistenz
Creators: name: Hirschberg, Marianne
Publisher: name: Universität Kassel
Year: 2017
Subjects: subject: Disability Studies
subject: Persönliche Assistenz
subject: Menschenrechte
subject: Conditio Humana
subject: 100
subject: 300
subject: 360
subject: Disability Studies
subject: Persönliche Assistenz
subject: Menschenrecht
subject: Conditio humana

description: Der Aufsatz wurde zuerst 2017 veröffentlicht im Sammelband „Autonomie und Menschenrechte am Lebensende“ von Caroline Welsch, Christoph Ostgathe, Andreas Frewer und Heiner Bielefeldt (Hrsg.), Bielefeld 2017 (transcript).
First-principles study of CO and OH adsorption on In-doped ZnO surfaces
Creators: name: Saniz, R.
name: Sarmadian, N.
name: Partoens, B.
name: Batuk, M.
name: Hadermann, J.
name: Marikutsa, A.
name: Rumyantseva, M.
name: Gaskov, A.
name: Lamoen, D.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a first-principles computational study of non-polar ZnO (10$\bar{1}$0) surfaces doped with indium. The calculations were performed using a model ZnO slab. The position of the In dopants was varied from deep bulk-like layers to the surface layers. It was established that the preferential location of the In atoms is at the surface by examining the dependence of the defect formation energy as well as the surface energy on In location. The adsorption sites on the surface of ZnO and the energy of adsorption of CO molecules and OH-species were determined in connection to In doping. It was found that OH has higher bonding energy to the surface than CO. The presence of In atoms at the surface of ZnO is favorable for CO adsorption, resulting in an elongation of the C-O bond and in charge transfer to the surface. The effect of CO and OH adsorption on the electronic and conduction properties of surfaces was assessed. We conclude that In-doped ZnO surfaces should present a higher electronic response upon adsorption of CO.
description: 9 pages, 13 figures; version with supporting additional material in appendix
WALLIS 2018 cruise,Alis R/V
Creators: name: Sylvain, PETEK
Publisher: name: Sismer
Year: 2018

description: Cette campagne avait pour objectifs de réaliser d'une part l'inventaire des spongiaires, des gorgones, des mollusques et des micro-mollusques de l'île de Wallis (Fig. 1), et d'autre part, concernant les spongiaires les plus abondants, d'en récolter une quantité suffisante pour la réalisation d'analyses chimiques et biologiques, pour des études métabolomiques dans la perspective d'applications en santé humaine notamment.Figure 1: Eponges, mollusque, gorgone et drapeau de l'île de Wallis
Investigation into the effects of elevated carbon dioxide and temperature on nutrient cycling and understorey vegetation in a Eucalyptus woodland
Creators: name: Hasegawa, Shun
Publisher: name: Imperial College London
Year: 2015

description: Forest ecosystems contribute substantially to biogeochemical processes on the earth. Understanding their responses to climate change is essential to the prediction of future climate as they could accelerate or decelerate the rates at which atmospheric CO2 concentrations and associated global temperatures are rising, depending on their carbon (C) storage capacity. However, very little is known about how mature forests respond to climate change, particularly those growing under P limitation, or NP co-limitation. This thesis aimed to investigate the effects of elevated (e)CO2 (ambient +150 ppm) on soil nutrient dynamics and understorey plant community composition in a novel field CO2 exposure experiment in a mature, P-limited, native Eucalyptus woodland (EucFACE). It also investigated the effects of elevated temperature (eTemp; ambient +3 ℃) on soil nutrient dynamics using whole-tree chambers (WTCs) in which Eucalyptus tereticornis trees were grown. I found seasonally-dependent positive effects of eCO2 on the availability and turnover of soil N and P over an 18-month period, with concurrent higher concentrations of dissolved organic carbon (DOC) in soil solution and lower soil pH. P availability was enhanced to a greater extent than N, resulting in decreased N:P ratios. The WTC experiment showed that, whilst eTemp enhanced P turnover and availability, and increased DOC in soil solution, effects on N availability and turnover were not statistically significant. In the case of both eCO2 and eTemp, increased DOC alongside increased soil P availability and decreased soil N:P ratios, suggests that plants adjusted their C investment strategies as their demand for nutrients, particularly P, increased. The EucFACE experiment also showed that eCO2 increased C3 plant species abundance compared to C4, and decreased species diversity in the understorey community. This thesis provides novel insights into and empirical evidence of soil nutrient, particularly P, dynamics under P-limited ecosystems in a higher CO2 and warmer world.
The role of hypoxia on interstitial mitral valve cells
Creators: name: Salhiyyah, Kareem
Publisher: name: Imperial College London
Year: 2014

description: Mitral valve disease is a multifactorial process. The valve is a complex structure that contains an amalgam of extracellular proteins, cellular components, nerves and blood vessels. It is predicted that some of the central portions of the valve leaflets could exist under hypoxic conditions. Hypoxia could play a role in initiating the structural changes in the valve that lead to dysfunction of the valve. It is known to cause the up-regulation of hypoxia-induced factor (HIF) that can regulate the differentiation of cells, the production of extracellular matrix (ECM) and expression of matrix remodelling enzymes, all of which are characteristic changes seen in one or more forms of the disease. This study aimed to investigate the effect of hypoxia on the basic behaviour and phenotypic profile of mitral valve interstitial cells (MVICs), and their functional response to produce and control the ECM components. The expression of HIF-1α and its role in mediating the effects induced by hypoxia were also investigated, and also the characteristics of blood vessels in the mitral valve leaflet in porcine as well as normal and diseased human valves. MVICs incubated under hypoxia remained viable and continued to grow, while retaining their morphology and phenotype. On the other hand, severe hypoxia resulted in reduced production of the ECM components sulphated glycosaminoglycan (sGAG) and collagen, while it induced matrix metabolism through up-regulating the gene expression of matrix metalloproteases and their tissue inhibitors. Human rheumatic valves had more evident expression of HIF-1α compared with normal or myxomatous degeneration valves. Porcine MVICs (pMVICs) expressed HIF-1α under hypoxia. Stimulating HIF-1α chemically causes a reduction in the amount of GAG produced, similar to the effect observed under severe hypoxia. The study also confirmed the presence of vascular supply to the normal mitral valve leaflets and showed that there was increased vascularisation in rheumatic valves, while there was a loss of vessels in myxomatous degenerative ones. In conclusion, normal mitral valve leaflets are vascular structures of variable pattern. Diseased valves are associated with changes in leaflet vascularity either by neovascularisation in rheumatic disease, or by loss of vascularisation in myxomatous degeneration. Hypoxia affects the production of certain ECM proteins and remodelling enzymes by MVICs. These effects appear to be mediated by the induction of HIF-1α. This study highlights an important process and mechanism in heart valve in health and disease and helps improve the understanding of its complex biology. This could have future implications on the treatment of valve disease and the future applications in heart valve tissue engineering.
Constituent Quark Model Calculation for a possible J^P=0^-,T=0 Dibaryon
Creators: name: Wagner, Georg
name: Glozman, L. Ya.
name: Buchmann, A. J.
name: Faessler, Amand
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: There exists experimental evidence that a dibaryon resonance d' with quantum numbers J^P=0^-,T=0 and mass 2065 MeV could be the origin of the narrow peak in the (π^+ ,π^- ) double charge exchange cross--sections on nuclei. We investigate the six--quark system with these quantum--numbers within the constituent quark model, with linear confinement, effective one--gluon exchange at short range and chiral interactions between quarks (πand σexchange). We classify all possible six quark states with J^P=0^-,T=0, and with N=1 and N=3 harmonic oscillator excitations, using different reduction chains. The six--quark Hamiltonian is diagonalized in the basis including the unique N=1 state and the 10 most important states from the N=3 shell. We find, that with most of the possible sets of parameters, the mass of such a "dibaryon" lies above the N(939)+N^\ast(1535) threshold. The only possibility to describe the supposed d'(2065) in the present context is to reduce the confinement strength to very small values, however at the expense of describing the negative parity resonances N^\ast. We also analyze the J^P=0^-,T=2,N=1 six--quark state.
description: 42 pages, Latex, submitted to Nucl.Phys. A
Dresdner Totengedenkbuch 1914-1918. Digitalisierung und Transkription
Creators: name: Munke, Martin
Publisher: name: Sächsische Landesbibliothek – Staats- und Universitätsbibliothek Dresden
Year: 2021
Subjects: Dresden
Erster Weltkrieg
Soldat
Crowdsourcing
Dateneingabesystem

description: Beim Transkriptionsprojekt „Dresdner Totengedenkbuch 1914-1918“ handelt es sich um ein gemeinschaftliches Vorhaben des Vereins für Computergenealogie e.V., des Dresdner Vereins für Genealogie e.V. und der Sächsischen Landesbibliothek – Staats- und Universitätsbibliothek Dresden (SLUB), basierend auf Quellenbeständen des Sächsischen Staatsarchivs – dem nie veröffentlichen Gedenkbuch für die Dresdner Gefallenen des Ersten Weltkriegs, von denen die auf Karteikarten erfassten persönlichen Informationen wie Name, Beruf, Familie etc. erhalten sind. Sie bilden eine wichtige, bisher weitgehend ungenutzte Quelle für die Militärgeschichte einer Großstadt im Ersten Weltkrieg, aber auch für die Sozial- und Familiengeschichte. Auch wenn es sich zunächst „nur“ um ein Crowdsourcing-Projekt handelt, bietet das Vorhaben die Grundlage für die Behandlung eigener Forschungsfragen sowohl durch forschende Bürger*innen wie auch durch die professionelle Wissenschaft, das über den engeren lokalen Kontext hinaus für vergleichende Studien geeignet ist und einen strukturierten Datenbestand zur freien Nutzung zur Verfügung stellen wird. Daneben lassen sich an diesem Beispiel Fragen des Projektdesigns sowie der Kommunikation und Kooperation in einem partnerschaftlichen Vorhaben von bürgerschaftlich organisierten Akteuren und staatlichen Gedächtnisinstitutionen untersuchen.
Reminiscences of Francis P. Mulcahy 1967
Publisher: name: Columbia University
Year: 2019
Subjects: Air pilots, Military
Aeronautics, Military
Aviation
World War, 1914-1918--Aerial operations, American
World War, 1939-1945--Aerial operations, American

description: Family background, education, University of Notre Dame 1910-1914; World War I service: pilot training, Marine air operations in France, early units and equipment; expeditionary duty Haiti, Nicaragua; development of Fleet Marine force air techniques; military observer with British air units in Middle East, 1941-42; World War II: Marine air operations at Guadalcanal, Okinawa.
Time-odd components in the mean field of rotating superdeformed nuclei
Creators: name: Dobaczewski, J.
name: Dudek, J.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Rotation-induced time-odd components in the nuclear mean field are analyzed using the Hartree-Fock cranking approach with effective interactions SIII, SkM*, and SkP. Identical dynamical moments ${{\cal J}^{(2)}}$ are obtained for pairs of superdeformed bands $^{151}$Tb(2)--$^{152}$Dy(1) and $^{150}$Gd(2)--$^{151}$Tb(1). The corresponding relative alignments strongly depend on which time-odd mean-field terms are taken into account in the Hartree-Fock equations.
description: 23 pages, ReVTeX, 6 uuencoded postscript figures included
Patella barbara Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Pezizales
Patellidae
Patella
Patella barbara

description: Patella barbara [spec. nov.]
P. testa dentata: costis novendecim elevatis forni- cato-muricatis. M. L. U.
Habitat ..
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 782, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Quantum Monte Carlo Calculations of $A\leq6$ Nuclei
Creators: name: Pudliner, B. S.
name: Pandharipande, V. R.
name: Carlson, J.
name: Wiringa, R. B.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The energies of $^{3}H$, $^{3}He$, and $^{4}He$ ground states, the ${\frac{3}{2}}^{-}$ and ${\frac{1}{2}}^{-}$ scattering states of $^{5}He$, the ground states of $^{6}He$, $^{6}Li$, and $^{6}Be$ and the $3^{+}$ and $0^{+}$ excited states of $^{6}Li$ have been accurately calculated with the Green's function Monte Carlo method using realistic models of two- and three-nucleon interactions. The splitting of the $A=3$ isospin $T=\frac{1}{2}$ and $A=6$ isospin $T=1$, $J^π = 0^{+}$ multiplets is also studied. The observed energies and radii are generally well reproduced, however, some definite differences between theory and experiment can be identified.
description: 12 pages, 1 figure
Additional file 1: of Effect of breastfeeding education and support intervention (BFESI)Â versus routine care on timely initiation and exclusive breastfeeding in Southwest Ethiopia: study protocol for a cluster randomized controlled trial
Creators: name: Misra Abdulahi
name: Fretheim, Atle
name: Magnus, Jeanette
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: SPIRIT 2013 Checklist for the BFESI cRCT. (DOC 124Â kb)
Probing the origin of extragalactic magnetic fields with Fast Radio Bursts
Creators: name: Vazza, F.
name: Brüggen, M.
name: Hinz, P. M.
name: Wittor, D.
name: Locatelli, N.
name: Gheller, C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The joint analysis of the Dispersion and Faraday Rotation Measure from distant, polarised Fast Radio Bursts may be used to put constraints on the origin and distribution of extragalactic magnetic fields on cosmological scales. While the combination of Dispersion and Faraday Rotation Measure can in principle give the average magnetic fields along the line-of-sight, in practice this method must be used with care because it strongly depends on the assumed magnetisation model on large cosmological scales. Our simulations show that the observation of Rotation Measures with $\geq 1-10 ~\rm rad/m^2$ in $\sim 10^2$ Fast Radio Bursts will be able to discriminate between extreme scenarios for the origin of cosmic magnetic fields, independent of the exact distribution of sources with redshift. This represent a strong case for incoming (e.g. ALERT, CHIME) and future (e.g. with the Square Kilometer Array) radio polarisation surveys of the sky.
description: 8 pages, 10 figures, MNRAS accepted, in press. A color-blind friendly version can be downloaded here https://storage.googleapis.com/wzukusers/user-14759165/documents/5b5586d8d71601wxVuGn/frb-magnetic-fields-6.pdf
WALVIS CH85 cruise,Jean Charcot R/V
Creators: name: NEEDHAM Hubert David
Publisher: name: Sismer
Year: 1979

description: L'origine et l'évolution structurale de la Ride de Walvis, exemple type de ride aséismique, constituent l'objectif premier de cette campagne. L'objectif second est d'aider à la détermination des sites d'implantation des futurs forages IPOD le long d'une radiale Bassin du Cap -Ride de Walvis -Bassin d'Angola. La majeure partie de la campagne est basée sur l'utilisation intensive et conjointe du sondeur multifaisceaux "SEABEAM", du sondeur à balayage latéral "GLORIA" et/ou de la sismique réflexion.
MOESM2 of Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production
Creators: name: Wang, Wei-wei
name: Wang, Jing
name: Zhang, Hai-jun
name: Wu, Shu-geng
name: Qi, Guang-hai
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Additional file 2: Clusters of Orthologous Genes (COG) classification of differentially expressed genes of the layer intestine between groups.
Haematopoietic stem cell mobilization and re-arrangement of immune cell subsets following therapeutic alpha 4-integrin blockade in multiple sclerosis: functional relevance, clinical correlations and applications
Creators: name: Mattoscio, Miriam
Publisher: name: Imperial College London
Year: 2015

description: The anti α-4 integrin antibody natalizumab is broadly used in clinical practice for treatment of active multiple sclerosis (MS). Previous studies reported an increase of circulating haematopoietic stem cells in natalizumab-treated MS patients yet the biological significance remained unclear. This research wanted to ascertain the mobilization from the bone marrow (BM) and the functional relevance of the increased number of circulating hematopoietic stem and progenitor cells (HSPC) induced by natalizumab in patients with MS. CD45lowCD34+ HSPC frequency was evaluated by flow-cytometry in the peripheral blood of 45 natalizumab-treated patients (12 of which were prospectively followed during the first year of treatment as part of a pilot cohort and 16 were prospectively followed for validation), 10 untreated MS patients and 24 healthy donors. In the natalizumab-treated group the cell cycle status of sorted HSPC was also evaluated, together with T- and B lymphocyte (n=29) and myeloid-derived suppressor cells subpopulation frequencies and HSPC differentiation potential (n=10). Moreover, an in vitro model was designed for studying the immune-modulatory effect of increasing concentrations of HSCP on the distribution of lymphocytes subsets in HSPC/mononuclear cells (MNC) co-cultures started from Cord Blood samples (n=5). Natalizumab-induced circulating HSPC were predominantly quiescent, suggesting recent mobilization from the BM, and were capable of differentiation ex vivo. Circulating HSPC numbers were significantly increased during natalizumab although heterogeneously, allowing the stratification of “Mobilizer” and “Non-Mobilizer” sub-groups. "Non-Mobilizer" status was associated with persistence of disease activity during treatment. The frequency of B cells, Transitional B regulatory cells and CD103+ CD8+ regulatory T cells persistently increased, more significantly in “Mobilizer” patients who also showed a specific naïve/memory B cell profile. Also the proportion of myeloid-derived suppressor cells (MDSC) was found to increase during natalizumab treatment, correlating with HSPC counts. In vitro, B regulatory cells proportions increased significantly upon addition of increasing concentrations of HSPC in co-cultures, while IL-6 concentration consistently decreased in co-cultures supernatant and level of IL-10 relatively increase. The data suggest that the natalizumab-induced circulating HSPC increase is the result of true mobilization from the BM and has clinical and immunological relevance. HSPC mobilization, associated with clinical remission and with increased proportion of circulating B and regulatory T cells and MDSC, may contribute to the treatment’s mode of action. Thus, HSPC blood counts could represent an early biomarker of responsiveness to natalizumab.
Additional file 1 of Strain-Tunable Electronic Properties and Band Alignments in GaTe/C2N Heterostructure: a First-Principles Calculation
Creators: name: Li, Xiao-Huan
name: Wang, Bao-Ji
name: Cai, Xiao-Lin
name: Yu, Wei-Yang
name: Zhu, Ying-Ying
name: Li, Feng-Yun
name: Fan, Rui-Xia
name: Zhang, Yan-Song
name: San-Huang Ke
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Figure S1. Band structures of the GaTe and C2N monolayers; Figure S2. Phonon spectrum and MD simulations of GaTe/C2N heterostructures; Figure S3. Band structures of the of GaTe/C2N heterostructures; Figure S4. The plane-averaged charge density difference of the heterostructure; Figure S5. The effect of normal strain on the interlayer interaction Figure S6. Projected band structures of the heterostructures under the various normal strains; Figure S7. Projected band structures of the heterostructures under the various in-plane strains. (PDF 3733 kb)
Modelling of the quasar main sequence in the optical plane
Creators: name: Panda, Swayamtrupta
name: Czerny, Bożena
name: Adhikari, Tek P.
name: Hryniewicz, Krzysztof
name: Wildy, Conor
name: Kuraszkiewicz, Joanna
name: Śniegowska, Marzena
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The concept of the quasar main sequence is very attractive since it stresses correlations between various parameters and implies the underlying simplicity. In the optical plane defined by the width of the H\{beta} line and the ratio of the equivalent width of the Fe II to H\{beta} observed objects form a characteristic pattern. In this paper, we use a physically motivated model to explain the distribution of quasars in the optical plane. Continuum is modelled as an accretion disk with a hard X-ray power law uniquely tight to the disk at the basis of observational scaling, and the Broad Line Region distance is determined also from observational scaling. We perform the computations of the FeII and H\{beta} line production with the code CLOUDY. We have only six free parameters for an individual source: maximum temperature of the accretion disk, Eddington ratio, cloud density, cloud column density, microturbulence, and iron abundance, and only the last four remain as global parameters in our modelling of the whole sequence. Our theoretically computed points cover well the optical plane part populated with the observed quasars, particularly if we allow for super-Solar abundance of heavy elements. Explanation of the exceptionally strong Fe II emitter requires a stronger contribution from the dark sides of the clouds. Analyzing the way how our model covers the optical plane we conclude that there is no single simple driver behind the sequence, as neither the Eddington ratio nor broad band spectrum shape plays the dominant role. Also, the role of the viewing angle in providing the dispersion of the quasar main sequence is apparently not as strong as expected.
description: 16 pages, 10 figures, accepted for publication in ApJ
WALVIS CH86 cruise,Jean Charcot R/V
Creators: name: NEEDHAM Hubert David
Publisher: name: Sismer
Year: 1979

description: Etude structurale de la ride Walvis dont l'origine est mal connue : en particulier, mieux comprendre la contribution des zones de fractures à la géométrie de la ride et reconnaitre d'autres structures fossiles de la Dorsale médio-océanique. En outre, la campagne a eu pour but de contribuer à la définition des sites de forages prévus dans le cadre d'IPOD. Les différents objectifs scientifiques de la campagne : voir compte-rendu de campagne.
Exact gravitational plane waves and two-dimensional gravity
Creators: name: Russo, Jorge G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss dynamical aspects of gravitational plane waves in Einstein theory with massless scalar fields. The general analytic solution describes colliding gravitational waves with constant polarization, which interact with scalar waves and, for generic initial data, produce a spacetime singularity at the focusing hypersurface. There is, in addition, an infinite family of regular solutions and an intriguing static geometry supported by scalar fields. Upon dimensional reduction, the theory can be viewed as an exactly solvable two-dimensional gravity model. This provides a new viewpoint on the gravitational dynamics. Finally, we comment on a simple mechanism by which short-distance corrections in the two-dimensional model can remove the singularity.
description: 8 pages
Development of scaffolds incorporating zonal complexity for articular cartilage tissue engineering
Creators: name: Steele, Joseph Allan McKinnon
Publisher: name: Imperial College London
Year: 2015

description: Articular cartilage is an anisotropic tissue composed of compositional and functional layers. One clinical approach to the regeneration of articular cartilage defects incorporates a porous polymer scaffold to support and direct cartilage formation in full‐thickness defects. These scaffolds are regularly isotropic in structure, unlike the tissue they aim to regenerate. A number of scaffold production techniques were combined to produce porous anisotropic scaffolds with zonally‐biomimetic microarchitecture and mechanical properties. The final scaffold design featured a combination of an electrospun fibrous superficial zone, isotropic foam intermediate zone and directionally frozen deep zone. The zonal scaffold microenvironments influenced cellular distribution, gene expression, and extracellular matrix deposition in vitro without requiring chemical modification or culture under dynamic loading. The scaffold development work culminated in a porcine in vivo study, currently on‐going. Initial data from the 3‐month preliminary surgical trial suggests full cellular infiltration of acellular scaffolds, no immunological response, and improved articular surface morphologies relative to empty defect controls. Variations on the polymer poly(ϵ‐caprolactone) (PCL) were investigated for use in osteochondral tissue engineering applications. The incorporation of alternate monomers was found to modify the biological and mechanical properties of the resulting materials and scaffolds. The work contained within this thesis has expanded the field of anisotropic scaffold design, with implications for articular cartilage engineering. The combination of electrospun fibres and anisotropic foams for scaffold engineering was the first in the field when published. The design of the third‐generation scaffold is new to the field, as is the order‐of‐magnitude increase in stiffness in a porous polymer scaffold while maintaining interconnectivity and polymer composition. The observation of differentially aligned ECM within a single multi‐layer scaffold without zonally distinct materials or surface functionalisation is also believed to be the first in the field.