cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Possible existence of wormholes in the central regions of halos
Creators: name: Rahaman, Farook
name: Salucci, P.
name: Kuhfittig, P. K. F.
name: Ray, Saibal
name: Rahaman, Mosiur
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: An earlier study [Rahaman et al. (2014) & Kuhfittig (2014)] has demonstrated the possible existence of wormholes in the outer regions of the galactic halo, based on the Navarro-Frenk-White (NFW) density profile. This paper uses the Universal Rotation Curve (URC) dark matter model to obtain analogous results for the central parts of the halo. This result is an important compliment to the earlier result, thereby confirming the possible existence of wormholes in most of the spiral galaxies.
description: 9 pages, 6 figures
Cbf genes of the Fr-A2 allele are differentially regulated between long-term cold acclimated crown tissue of freeze-resistant and susceptible, winter wheat mutant lines
Creators: name: Chen, D.-G.
name: Kenefick, D.
name: Sutton, F.
name: Ge, X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Background: In order to identify genes that might confer and maintain freeze resistance of winter wheat, a comparative transcriptome analysis was performed between control and 4 wk cold-acclimated crown tissue of two winter wheat lines that differ in field freeze survival. The lines, generated by azide mutagenesis of the winter wheat cultivar 'Winoka' were designated FR (75% survival) and FS (30% survival). Using two winter lines for this comparative analysis removed the influence of differential expression of the vernalization genes and allowed our study to focus on Cbf genes located within the Fr-A2 allele independent of the effect of the closely mapped Vrn allele. Results: Vernalization genes, (Vrn-A1, B1 and D1), and the transcription factor gene, TaVrt-2, were up-regulated to the same extent in FR and FS lines with cold acclimation thus confirming that azide mutagenesis had not modified the winter habitat of the lines. One category of Cbf genes, (Cbf-2, -A22 and B-22) reflected an increase in level of expression with cold acclimation in both FR and FS lines. Another category of Cbf genes (Cbf-3, -5, -6, -12, -14 and -19) were differentially expressed between cold-acclimated FR and FS lines relative to the non-acclimated controls. Comparison of expression patterns of the two categories of Cbf genes with the expression patterns of a set of ABA-dependent and -independent Cor/Lea genes revealed similar patterns of expression for this sample of Cor/Lea genes with that for Cbf-2 and -22. This pattern of expression was also exhibited by the Vrn genes. Conclusion: Some Cor/Lea genes may be co-regulated by the Vrn genes during cold acclimation and the Vrn genes may also control the expression of Cbf-2, -A22 and -B22. The increased freeze survival by the FR line and the increase in expression levels of wheat Cbf genes, Cbf-3, -5, -6, -12, -14 and -19 with cold acclimation in the FR line suggests a possible gain of function mutation resulting in higher levels of expression of these Cbf genes and increased freeze survival.
Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis
Creators: name: Fu, L.
name: Deeb, S.S.
name: Chen, D.-G.
name: Liu, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Using the human WERI-Rb1 cell line as a model system, we performed a genome-wide search for retinal target genes of thyroid hormone (TH) via expression microarray analysis followed by quantitative real-time RT-PCR verification. We identified 12 novel retinal targets of TH, including 10 up-regulated genes (OPN1MW, OPN1LW, TIMP3, RP1L1, GNGT2, CRX, ARR3, GCAP1, IMPDH1, and PDE6C) and 2 down-regulated genes (GNGT1 and GNB3). In addition, we found a number of novel TH-targets that are not currently known to be retinal genes. This is the first report of human retinal targets regulated by thyroid hormone.
A nonlinear isobologram model with Box-Cox transformation to both sides for chemical mixtures
Creators: name: Chen, D.G.
name: Pounds, J.G.
Publisher: name: Public Health Services, US Dept of Health and Human Services
Year: 1998

description: The linear logistical isobologram is a commonly used and powerful graphical and statistical tool for analyzing the combined eifects of simple chemical mixtures. In this paper a nonlinear isobologram model is proposed to analyze the joint action of chemical mixtures for quantitative dose-response relationships. This nonlinear isobologram model incorporates two additional new parameters, Y(min) and Y(max), to facilitate analysis of response data that are not constrained between 0 and 1, where parameters Y(min) and Y(max) represent the minimal and the maximal observed toxic response. This nonlinear isobologram model for binary mixtures can be expressed as: @?. In addition, a Box-Cox transformation to both sides is introduced to improve the goodness of fit and to provide a more robust model for achieving homogeneity and normality of the residuals. Finally, a confidence band is proposed for selected isobols, e.g., the median effective dose, to facilitate graphical and statistical analysis of the isobologram. The versatility of this approach is demonstrated using published data describing the toxicity of the binary mixtures of citrinin and ochratoxin as well as a new experimental data from our laboratory for mixtures of mercury and cadmium.
Archiv Orgelbau Kuhn. Inventar
Creators: name: Becker, Gerhard
Publisher: name: Musikbibliothek Hochschule Luzern
Year: 2023

description: Die Gründung der Orgelbauwerkstatt Kuhn erfolgte im Jahre 1864, als die Firma E. F. Walcker & Cie. in Ludwigsburg (Württemberg) eine Orgel mit zwei Manualen und Pedal in der Reformierten Kirche Männedorf aufstellte. Die beiden Arbeiter, welche Walcker nach Männedorf sendete, waren Johann Nepomuk Kuhn (1827-1888) und Johann Spaich (1813-1885). Die hier niedergelassenen Orgelbauer empfahlen sich für jährliches Stimmen der Kirchenorgel und gründeten ihr eigenes Unternehmen. Ab 1872 führte Johann Nepomuk Kuhn die Firma allein weiter, die sich in der Folge, speziell unter der Führung seines Sohnes Carl Theodor Kuhn (1865-1925), zum grössten Orgelbauunternehmen der Schweiz entwickeln konnte. Nach dem Tod von Carl Theodor Kuhn im Jahre 1925 wurde die Firma in eine Aktiengesellschaft mit verschiedenen technischen Leitern umgewandelt. 1967 wurde Friedrich Jakob zum Direktor berufen, der 1974 eine interne Restaurierungsabteilung unter der Leitung von Wolfgang Rehn gründete. 1998 wurden alle Aktien in die Hände der Geschäftsleitung (Dieter Utz) zusammengeführt. Zurzeit wird die Firma durch ein Team unter der Leitung von Intonateur Gunter Böhme geführt. Im Zuge der Firmen-Neustrukturierung im Jahre 2020 wurden die Akten von Orgeln, welche nicht durch Kuhn gebaut worden sind, aber deren Unterhalt sie während verschiedener Jahre übernommen hatte, dem ODZ vermachtet.
Employing supervised algorithms for the prediction of nanomaterial’s antioxidant efficiency
Creators: name: Mirzaei, Mahsa
name: Furxhi, Irini
name: MURPHY, FINBARR
name: MULLINS, MARTIN
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 350103
subject: Financial accounting

description: Reactive oxygen species (ROS) are compounds that readily transform into free radicals. Excessive exposure to ROS depletes antioxidant enzymes that protect cells, leading to oxidative stress and cellular damage. Nanomaterials (NMs) exhibit free radical scavenging efficiency representing a potential solution for oxidative stress-induced disorders. This study aims to demonstrate the application of machine learning (ML) algorithms for predicting the antioxidant efficiency of NMs. We manually compiled a comprehensive dataset based on a literature review of 62 in vitro studies. We extracted NMs’ physico-chemical (P-chem) properties, the NMs’ synthesis technique and various experimental conditions as input features to predict the antioxidant efficiency measured by a 2,2- diphenyl-1-picrylhydrazyl (DPPH) assay. Following data pre-processing, various regression models were trained and validated. The random forest model showed the highest predictive performance reaching an R2 = 0.83. The attribute importance analysis revealed that the NM’s type, core-size and dosage are the most important attributes influencing the prediction. Our findings corroborate with those of the prior research landscape regarding the importance of P-chem characteristics. This study expands the application of ML in the nano-domain beyond safety-related outcomes by capturing the functional performance. Accordingly, this study has two objectives: (1) to develop a model to forecast the antioxidant efficiency of NMs to complement conventional in vitro assays and (2) to underline the lack of a comprehensive database and the scarcity of relevant data and/or data management practices in the nanotechnology field, especially with regards to functionality assessments.
Heavy flavor and quarkonia production in PHENIX
Creators: name: Frawley, Anthony
Publisher: name: Zenodo
Year: 2022
Subjects: qnp22
phenix
heavy flavor
charmonium
au+au
dielectron
dimuon
dca
charm
bottom
raa
nuclear
modification
elliptic
flow
J/Ψ
multiplicity
p+p
p+au
3he+au

description: Talk presented at the International Conference on Quarks and Nuclear Physics Conference 2022
Bismuth-based perovskites as multiferroics
Creators: name: Guennou, Mael
name: Viret, Michel
name: Kreisel, Jens
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: This review devoted to multiferroic properties of Bismuth-based perovskites falls into two parts. The first part focuses on BiFeO3 and summarizes the recent progress made in the studies of its pressure-temperature phase diagram and magnetoelectric coupling phenomena. The second part discusses in a more general way the issue of polar - and multiferroic - phases in BiBO3 perovskites and the competition between ferroelectricity and other structural instabilities, from an inventory of recently synthetized compounds.
description: 22 pages, 7 figures, to be published in Comptes Rendus Physique
Electromagnetic Analysis and Modeling of Human Body Communication
Creators: name: Nath, Mayukh
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 400807
subject: Engineering electromagnetics

description: Progress in miniaturized computing and connectivity has led to a plethora of smart connected electronic devices around humans, leading us towards the era of seamless human-electronics co-operation. In this connected society, radiative communication using electromagnetic fields is the backbone of inter-device connectivity. This unfortunately leads to high power usage as well as physical signals being available for malicious interceptors to snoop. To address the need of security and energy efficiency of inter-device communication for devices on and around the human body, Human Body Communication (HBC) has been proposed. The fundamental philosophy of HBC is to use the human body as a medium - thus being helped and not hurt by the body - for communication between devices. Confinement of a signal within the body implies higher security as well as efficiency. This dissertation is an analysis of these properties of different HBC modalities, through electromagnetic modelling, simulation, and experienced. Electro-quasistatic (EQS) HBC has been explored in significant detail, including a complete theoretical formulation of return path capacitance, as well as a study of inter-body coupling for interference and security management in EQS-HBC. Magnetic modes of HBC have also been analyzed, and compared with its electric counterparts. Finally, a novel HBC technique, GSW-HBC, has been proposed. GSW-HBC or a Goubau line inspired surface wave based HBC, is shown to be a viable, secure and energy efficient alternative to RF wireless communication, leading the search for Gbps communication around the body.In reference to IEEE copyrighted material which is used with permission in this thesis, the IEEE does not endorse any of Purdue University's products or services. Internal or personal use of this material is permitted. If interested in reprinting/republishing IEEE copyrighted material for advertising or promotional purposes or for creating new collective works for resale or redistribution, please go to http://www.ieee.org/publications_standards/publications/rights/rights_link.html to learn how to obtain a License from RightsLink.
Exploring Eviction Data Collection Methods
Creators: name: Prunkl, Lauren
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Having access to stable housing is a necessity for everyone because evidence shows that stable housing is linked to numerous health and well-being outcomes. Whether informal or formal, evictions disrupt individuals’ ability to maintain stable housing. Data on evictions is often inconsistent leading to poor data quality. This adversely impacts a complex assembly of public and private actors including tenants, landlords, researchers and analysts, policy makers, attorneys, non-profit and governmental staff in their ability to support data informed policy, advocate for, provide, or obtain stable housing.
 
This report focuses on eviction court record-keeping practices locally in Greenville County, SC as well as three additional counties for examples of different practices: Charleston, SC, Durham, NC, and Milwaukee, WI. This research uses semi-structured interviews to gain a more nuanced understanding of the specific challenges public and private actors face when using or accessing court records and future opportunities for advocating for high-quality eviction data to increase access to stable housing and improve health and well-being outcomes. The report concludes with opportunities to foster data consistency, tenant support, and collaboration in Greenville, South Carolina at both local and state scales.
Chiral structures and defects of lyotropic chromonic liquid crystals induced by saddle-splay elasticity
Creators: name: Davidson, Zoey S.
name: Kang, Louis
name: Jeong, Joonwoo
name: Still, Tim
name: Collings, Peter J.
name: Lubensky, Tom C.
name: Yodh, A. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: An experimental and theoretical study of lyotropic chromonic liquid crystals (LCLCs) confined in cylinders with degenerate planar boundary conditions elucidates LCLC director configurations. When the Frank saddle-splay modulus is more than twice the twist modulus, the ground state adopts an inhomogeneous escaped-twisted configuration. Analysis of the configuration yields a large saddle-splay modulus, which violates Ericksen inequalities but not thermodynamic stability. Lastly, we observe point defects between opposite-handed domains and explain a preference for point defects over domain walls.
Disinformation in the context of health information behaviour
Creators: name: Bressel, Paulina
name: Dewitz, Leyla
name: Henkel, Maria
name: Stiller, Juliane
name: Trkulja, Violeta
Publisher: name: Zenodo
Year: 2022
Subjects: disinformation
health information behaviour
health information

description: Introduction slides of the panel "Disinformation in the context of health information behaviour" at the ISIC-Conference 2022 in Berlin. The panel had the following members: Elena Macevičiūtė (Swedish School of Library and Information Science, University of Boras in Sweden), Kristina Eriksson-Backa (at Åbo Akademi University, Finland), Isto Huvila (Uppsala University, Sweden), Thomas Mandl (University of Hildesheim)
description: Das Projekt wird gefördert durch das Bundesministerium für Bildung und Forschung im Rahmen der Maßnahme "Forschung Agil - Erkennen und Bekämpfung von digitalen Desinformationskampagnen".
Decarbonization of Housing in California
Creators: name: Prieto, Julia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The state of California has set ambitious climate goals. Its 2006 Global Warming Solutions Act aimed to reduce GHG emissions to 1990 levels by 2020. Now, the state aims to be carbon neutral by 2045 or earlier. Buildings are the second largest source of GHG emissions, after transportation. This paper examines the current legal framework through which the decarbonization of buildings is expected to occur. It uses San Diego as a case study to illustrate the limitations of the current framework. Finally, it offers recommendations to align California’s climate goals with its actions on decarbonization of housing.
title: Energy deposition of ultrashort laser pulses in polyvinyl chloride measured by two-color pump-probe shadowgraphy
Creators: name: Schott, Nils
name: Schaumann, Gabriel
name: Brönner, Matthias
name: Christ, Fabian
name: Roth, Markus
Publisher: name: Springer
Year: 2025

description: We report on the energy deposition of ultrashort laser pulses with two different intensities of 6 TW cm⁻² and 143 TW cm⁻² in polyvinyl chloride, using two-color pump-probe shadowgraphy. The interaction is imaged during the pulse propagation into the medium and up to 200 μs after. The shadowgraphs show that higher-intensity pulses induce significantly more ionization of the material. Furthermore, it is shown that lower-intensity pulses propagate over the entire visible range of the shadowgraph without major losses, while higher-intensity pulses fade significantly after about 200 μs. After the interaction, pulses of both intensities produce a similar temperature-induced shadowgraphy pattern. The observations of the ionization process, the propagation of the pulse in the medium, and the thermalization are explained based on theory regarding ultrashort pulse laser interaction with dielectrics. Furthermore, the ablation craters produced by multiple consecutive pulses of both intensities are compared. The crater produced with lower-intensity pulses shows trails of material change significantly below the ablation crater, while these trails do not exist when using pulses with higher intensity. This is attributed to the differences in pulse propagation observed in the shadowgraphs of single pulses. This work demonstrates, for the first time, the intensity dependence of energy deposition of ultrashort laser pulses in polyvinyl chloride and its consequences for laser micromachining.
Thirty Shades of Green: Land Use Regulation of Adult-Use Cannabis in the United States
Creators: name: Lagoo, Tasmaya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Over one third of US states have legalized cannabis/marijuana for non-medicinal use over the last ten years and there is an ongoing push for broader legalization. For local communities, the adult-use cannabis industry can pose both tremendous opportunities and significant challenges. This report examines state and local land use regulations related to the adult-use cannabis industry and is primarily intended to aid professional planners tasked with designing and implementing land use regulations for this rapidly growing industry. The report demonstrates that foundational land use planning tools such as buffers and zoning restrictions can be deployed in a variety of ways to incorporate the adult-use cannabis industry into a community’s distinct needs and character.
H20 PAYLOAD Prototype presentation
Creators: name: Egyed Péter
Publisher: name: Zenodo
Year: 2023

description: A projekt célja egy univerzális, CDA technológia kifejlesztése. A projekt célja egy komplett drónra szerelt permetezőegység kifejlesztése volt, amelyet kifejezetten a kereskedelmi forgalomban kapható Hercules H20 drónokhoz terveztek. A kutatás-fejlesztési tevékenységek során az elvégzett végeselem-analízisek és az alkalmazott gyártási technológiák alapján több prototípus is elkészült a végső, teljesen integrált H20 hasznos teherbírásig, amely minden célkitűzésnek megfelel és a gyakorlatban is alkalmazható.
 A kutatás-fejlesztési projektben 18 fő vett részt: 1 projektvezető, 6 kutató és 11 technikus.
description: GINOP-2.1.2-8-1-4-16-2018-00694
Fake scientific provenance as a driver for disinformation – Peoples' disinformation behavior in health contexts
Creators: name: Stiller, Juliane
name: Dewitz, Leyla
Publisher: name: Zenodo
Year: 2022
Subjects: disinformation
health information
health information behaviour

description: Presentation from the ASIS&T 24-Hour Global Conference
description: Das Projekt wird gefördert durch das Bundesministerium für Bildung und Forschung im Rahmen der Maßnahme "Forschung Agil - Erkennen und Bekämpfung von digitalen Desinformationskampagnen"
A STRATEGIC FRAMEWORK TO DESIGN CONTEXT-SPECIFIC TRAININGS PROGRAMS TO IMPROVE PROJECT MANAGEMENT PERFORMANCE IN PAKISTAN
Creators: name: Dr. SADIA HANIF
name: Dr. MEHWISH JABEEN
name: Dr. SHAISTA NASIR
name: Dr. NASIR HUSSAIN
Publisher: name: Zenodo
Year: 2023
Subjects: Knowledge transfer, Contextualized trainings, organizational needs, Project manager's competencies, Project Management training

description: Abstract
This study addresses the need for Strategic Framework to Design Context-Specific Trainings to improve project management competencies. We conduct interviews with project managers to build a typology of contextualizing factors that impact on project management training in Pakistan through grounded theory approach. Using these factors, we propose a strategic framework to design context-specific training programs based on information provided by organizational needs assessment. We demonstrate the utility of such a needs assessment in a poorly studied industry sector and socio-geographic setting, among public service project managers in Pakistan, considering the training needs of project managers and the organizational capability of their workplaces. This study demonstrates the importance of contextual training for the development of training programs that are responsive to organizational capacity. The results of this study are discussed in context with projectification, building organizational capability and improving project management training, particularly in developing countries to improve project manager's competencies
MAPPING ATTITUDES ON ILLEGAL WILDLIFE TRADE: IMPLICATIONS FOR MANAGEMENT AND GOVERNANCE
Creators: name: Arroyave, Felber
name: Jenkins, Jeffrey
name: Hurtado, Rafael
Publisher: name: Zenodo
Year: 2023
Subjects: wild species, trade on wildlife, governmentality, environmentality, narratives, competing uses

description: Abstract Illegal wildlife trade (IWT) is a problem that affects societies and ecosystems alike. However, it remains unclear which management strategies are suitable for addressing this issue, particularly when one considers the diversity of actors, interests, and nuances of the problem. We argue that better management strategies require multiple – and at times, even opposite – actors to coalesce around the fundamentals of the problem. An initial step towards formulating management strategies is to identify how the multiple actors involved understand the problem and its possible solutions (i.e. their attitudes). Although previous studies have addressed actors’ attitudes regarding IWT, they have rarely evaluated how attitudes vary between different actors. Against this backdrop, this study uses mixed methods to evaluate convergences in the attitudes of multiple actors (e.g. poachers, authorities, police forces and academics, among others) in Colombia. Importantly, this work has revealed that multiple IWT-related attitudes exist and are not necessarily shaped by contextual factors (e.g. social relations); instead, they are explained by actors’ experiences and preferred governance forms. We argue that consensus formation between the multiple parties involved is required to overcome institutional weaknesses, perception divergences and the differences in governance preferences for an efficient management of IWT.
DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding
Creators: name: McGinty, R.K.
name: Smith, C.B.
name: Geil, C.N.
name: Spangler, C.J.
name: Wang, G.G.
name: Li, D.
name: Yadav, S.P.
name: Lee, T.-H.
Publisher: name: Elsevier B.V.
Year: 2022

description: DOT1L methylates histone H3 lysine 79 during transcriptional elongation and is stimulated by ubiquitylation of histone H2B lysine 120 (H2BK120ub) in a classical trans-histone crosstalk pathway. Aberrant genomic localization of DOT1L is implicated in mixed lineage leukemia (MLL)-rearranged leukemias, an aggressive subset of leukemias that lacks effective targeted treatments. Despite recent atomic structures of DOT1L in complex with H2BK120ub nucleosomes, fundamental questions remain as to how DOT1L-ubiquitin and DOT1L-nucleosome acidic patch interactions observed in these structures contribute to nucleosome binding and methylation by DOT1L. Here, we combine bulk and single-molecule biophysical measurements with cancer cell biology to show that ubiquitin and cofactor binding drive conformational changes to stimulate DOT1L activity. Using structure-guided mutations, we demonstrate that ubiquitin and nucleosome acidic patch binding by DOT1L are required for cell proliferation in the MV4; 11 leukemia model, providing proof of principle for MLL targeted therapeutic strategies.
Proof of the local mass-angular momenta inequality for $U(1)^2$ invariant black holes
Creators: name: Alaee, Aghil
name: Kunduri, Hari K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider initial data for extreme vacuum asymptotically flat black holes with $\mathbb{R} \times U(1)^2$ symmetry. Such geometries are critical points of a mass functional defined for a wide class of asymptotically flat, `$(t-ϕ^i)$' symmetric maximal initial data for the vacuum Einstein equations. We prove that the above extreme geometries are local minima of mass amongst nearby initial data (with the same interval structure) with fixed angular momenta. Thus the ADM mass of nearby data $m\geq f(J_1,J_2)$ for some function $f$ depending on the interval structure. The proof requires that the initial data of the critical points satisfy certain conditions that are satisfied by the extreme Myers-Perry and extreme black ring data.
description: v2. statement of main theorem clarified, various minor improvements and clarifications
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding
Creators: name: Major, M.B.
name: Grant, G.D.
name: Brown, N.G.
name: Spangler, C.J.
name: Hathaway, N.A.
name: Yan, X.
name: Skrajna, A.
name: Kedziora, K.M.
name: Barbour, E.H.
name: Cook, J.G.
name: McGinty, R.K.
name: Goldfarb, D.
name: Cousins, E.M.
Publisher: name: Oxford University Press
Year: 2020

description: Nuclear proteins bind chromatin to execute and regulate genome-templated processes. While studies of individual nucleosome interactions have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to chromatin, the pervasiveness of acidic patch binding and whether other nucleosome binding hot-spots exist remain unclear. Here, we use nucleosome affinity proteomics with a library of nucleosomes that disrupts all exposed histone surfaces to comprehensively assess how proteins recognize nucleosomes. We find that the acidic patch and two adjacent surfaces are the primary hot-spots for nucleosome disk interactions, whereas nearly half of the nucleosome disk participates only minimally in protein binding. Our screen defines nucleosome surface requirements of nearly 300 nucleosome interacting proteins implicated in diverse nuclear processes including transcription, DNA damage repair, cell cycle regulation and nuclear architecture. Building from our screen, we demonstrate that the Anaphase-Promoting Complex/Cyclosome directly engages the acidic patch, and we elucidate a redundant mechanism of acidic patch binding by nuclear pore protein ELYS. Overall, our interactome screen illuminates a highly competitive nucleosome binding hub and establishes universal principles of nucleosome recognition.
Structural basis of nucleosome-dependent cGAS inhibition
Creators: name: Liu, P.
name: Spangler, C.J.
name: McGinty, R.K.
name: Cesmat, A.P.
name: Zhang, Q.
name: Strauss, J.D.
name: Boyer, J.A.
Publisher: name: American Association for the Advancement of Science
Year: 2020

description: Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) recognizes cytosolic foreign or damaged DNA to activate the innate immune response to infection, inflammatory diseases, and cancer. By contrast, cGAS reactivity against self-DNA in the nucleus is suppressed by chromatin tethering. We report a 3.3-angstrom-resolution cryo-electron microscopy structure of cGAS in complex with the nucleosome core particle. The structure reveals that cGAS uses two conserved arginines to anchor to the nucleosome acidic patch. The nucleosome-binding interface exclusively occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and sterically prevents cGAS from oligomerizing into the functionally active 2:2 cGAS-dsDNA state. These findings provide a structural basis for how cGAS maintains an inhibited state in the nucleus and further exemplify the role of the nucleosome in regulating diverse nuclear protein functions.
Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase
Creators: name: Hsu, A.
name: Baird, M.R.
name: Anderson, C.J.
name: Barbour, E.H.
name: McGinty, R.K.
name: Koyama, Y.
name: Borgnia, M.J.
Publisher: name: Elsevier B.V.
Year: 2019

description: Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histone crosstalk pathway, requiring prior histone H2B ubiquitylation of lysine 120 (H2BK120ub) for optimal activity. However, the molecular details describing both how Dot1L binds to the nucleosome and why Dot1L is activated by H2BK120 ubiquitylation are unknown. Here, we present the cryoelectron microscopy (cryo-EM) structure of Dot1L bound to a nucleosome reconstituted with site-specifically ubiquitylated H2BK120. The structure reveals that Dot1L engages the nucleosome acidic patch using a variant arginine anchor and occupies a conformation poised for methylation. In this conformation, Dot1L and ubiquitin interact directly through complementary hydrophobic surfaces. This study establishes a path to better understand Dot1L function in normal and leukemia cells. © 2019 The AuthorsDot1L is a histone H3K79-specific methyltransferase that is critical to the pathogenesis of leukemia. Here, Anderson et al. report the cryo-EM structure of Dot1L in complex with a ubiquitylated nucleosome, providing molecular details of how Dot1L binds its nucleosome substrate and is activated by ubiquitin.
Desinformationen im Gesundheitsbereich: Warnsignale erkennen und Resilienz stärken
Creators: name: Stiller, Juliane
Publisher: name: Zenodo
Year: 2022
Subjects: Desinformation
Falschinformation
Gesundheitsinformation
Gesundheitsinformationsverhalten

description: Vortrag auf der Zusatzveranstaltung des KOBV-Forum 2022 zum Thema “Gesellschaftliche Verantwortung von Bibliotheken in Krisenzeiten”, die am 23. August 2022 von 10:00-12:30 Uhr online statt fand.
description: Das Projekt wird gefördert durch das Bundesministerium für Bildung und Forschung im Rahmen der Maßnahme "Forschung Agil - Erkennen und Bekämpfung von digitalen Desinformationskampagnen"
The Untapped Potential of CAR-T Therapy Future Approaches and Case Management.pdf
Creators: name: Weginwar, Onkar
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420302
subject: Digital health

description: Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain hematological malignancies, showcasing remarkable clinical responses. This whitepaper explores the current landscape of CAR-T therapy, highlighting its successes and challenges. It delves into the untapped potential of CAR-T therapy, discussing innovative strategies, emerging technologies, and the crucial role of case management in optimizing patient outcomes.
Torsional response of relativistic fermions in $2+1$ dimensions
Creators: name: Valle, Manuel
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the equilibrium partition function of an ideal gas of Dirac fermions minimally coupled to torsion in $2+1$ dimensions. We show that the energy-momentum tensor reproduces the Hall viscosity and other parity violating terms of first order in the torsion. We also consider the modifications of the constitutive relations, and classify the corresponding susceptibilities. An entropy current consistent with zero production of entropy in equilibrium is constructed.
description: 13 pages; v2: improved discussion in sections 3 and 5, references added, matches the journal version
R&D collaboration networks in robotics: A geographical perspective using worldwide co-patent data
Creators: name: Scherngell, Thomas
name: Schwegmann, Katharina
name: Zahradnik, Georg
Publisher: name: Zenodo
Year: 2022
Subjects: R&D networks, R&D collaboration, R&D internationalization, Co-patents, robotics, Globalization, Social Network Analysis

description: The purpose of this study is to identify R&D hot spots and characterize the structure and dynamics of global R&D collaboration networks in robotics from a geographical perspective. We use patents as marker for R&D activities, and accordingly focus on technologically oriented R&D. In its empirical strategy, the study draws on information on patents applied for between 2002 and 2016. We employ a search strategy to identify relevant robotics patents based on detailed levels of the Cooperative Patent Classification (CPC). One of the most innovating elements is the assignment of all patents to more than 900 global urban areas based on the inventor addresses given in the patents and their geocoding. The co-patent networks are examined from a Social Network Analysis (SNA) perspective by means of robotics co-patents also observed for the time period 2002 to 2016, giving rising to a global network where urban areas are the nodes inter-linked by joint inventive activities recorded in robotics patents. Global SNA measures illustrate structures and dynamics of the network as a whole, while local measures indicate the specific positioning and roles of urban areas in the network. The results highlight most prominent urban hot spots in terms of specializing in robotics R&D, pointing to the increasing role of emerging economies, in particular China. The global robotics R&D has grown immense both in total patenting, but also in terms of R&D collaboration activities between urban areas. Also for the networks, growth is not equally distributed, but is characterized by significant spatial shifts, both in terms of cities declining or climbing up the specialization ranking, but even more in terms of the spatial network structure.
Octonacci Photonic Quasicrystals
Creators: name: Brandão, E. R.
name: Costa, C. H.
name: Vasconcelos, M. S.
name: Anselmo, D. H. A. L.
name: Mello, V. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We study theoretically the transmission spectra in one-dimensional photonic quasicrystals, made up of SiO$_2$($A$) and TiO$_2$($B$) materials, organized following the Octonacci sequence, where the $n$th-stage of the multilayer $S_{n}$ is given by the rule $S_{n}=S_{n-1}S_{n-2}S_{n-1}$, for $n\geq 3$ and with $S_{1}=A$ and $S_{2}=B$. The expression for transmittance was obtained by employing a theoretical calculation based in the transfer-matrix method. To normally incident waves, we observe that, for a same generation, the transmission spectra for TE and TM waves are equal, at least qualitatively, and they present a scaling property where a self-similar behavior is obtained, as an evidence that these spectra are fractals. The spectra show regions where the omnidirectional band gaps emerges for specific generations of Octonacci photonic structure, except to TM waves. For TE waves, we note that all of them have the almost same width, for different generations. We also report the localization of modes as a consequence of the quasiperiodicity of the heterostructure
description: Submitted to Optical Materials
The Origin of the Hot Gas in the Galactic Halo: Testing Galactic Fountain Models' X-ray Emission
Creators: name: Henley, David B.
name: Shelton, Robin L.
name: Kwak, Kyujin
name: Hill, Alex S.
name: Mac Low, Mordecai-Mark
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We test the X-ray emission predictions of galactic fountain models against XMM-Newton measurements of the emission from the Milky Way's hot halo. These measurements are from 110 sight lines, spanning the full range of Galactic longitudes. We find that a magnetohydrodynamical simulation of a supernova-driven interstellar medium, which features a flow of hot gas from the disk to the halo, reproduces the temperature but significantly underpredicts the 0.5-2.0 keV surface brightness of the halo (by two orders of magnitude, if we compare the median predicted and observed values). This is true for versions of the model with and without an interstellar magnetic field. We consider different reasons for the discrepancy between the model predictions and the observations. We find taking into account overionization in cooled halo plasma, which could in principle boost the predicted X-ray emission, is unlikely in practice to bring the predictions in line with the observations. We also find that including thermal conduction, which would tend to increase the surface brightnesses of interfaces between hot and cold gas, would not overcome the surface brightness shortfall. However, charge exchange emission from such interfaces, not included in the current model, may be significant. The faintness of the model may also be due to the lack of cosmic ray driving, meaning that the model may underestimate the amount of material transported from the disk to halo. In addition, an extended hot halo of accreted material may be important, by supplying hot electrons that could boost the emission of the material driven out from the disk. Additional model predictions are needed to test the relative importance of these processes in explaining the observed halo emission.
description: 11 pages, 3 figures. Accepted for publication in the Astrophysical Journal
A GPU-Based Wide-Band Radio Spectrometer
Creators: name: Chennamangalam, Jayanth
name: Scott, Simon
name: Jones, Glenn
name: Chen, Hong
name: Ford, John
name: Kepley, Amanda
name: Lorimer, D. R.
name: Nie, Jun
name: Prestage, Richard
name: Roshi, D. Anish
name: Wagner, Mark
name: Werthimer, Dan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Graphics Processing Unit (GPU) has become an integral part of astronomical instrumentation, enabling high-performance online data reduction and accelerated online signal processing. In this paper, we describe a wide-band reconfigurable spectrometer built using an off-the-shelf GPU card. This spectrometer, when configured as a polyphase filter bank (PFB), supports a dual-polarization bandwidth of up to 1.1 GHz (or a single-polarization bandwidth of up to 2.2 GHz) on the latest generation of GPUs. On the other hand, when configured as a direct FFT, the spectrometer supports a dual-polarization bandwidth of up to 1.4 GHz (or a single-polarization bandwidth of up to 2.8 GHz).
description: 5 pages, 3 figures, Accepted for publication in PASA
Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation
Creators: name: Muir, T.W.
name: Kim, J.
name: Kim, J.-A.
name: McGinty, R.K.
name: Jeon, J.
Publisher: name: Oxford University Press
Year: 2018

description: H2B ubiquitylation (H2Bub)-dependent H3K4 methylation is mediated by the multisubunit Set1 complex (Set1C) in yeast, but precisely how Set1C subunits contribute to this histone modification remains unclear. Here, using reconstituted Set1Cs and recombinant H2Bub chromatin, we identified Set1C subunits and domains involved in the H2Bub-dependent H3K4 methylation process, showing that the Spp1 PHDL domain, in conjunction with the Set1 n-SET domain, interacts with Swd1/Swd3 and that this interaction is essential for H2Bub-dependent H3K4 methylation. Importantly, Set1C containing an Spp1-Swd1 fusion bypasses the requirement for H2Bub for H3K4 methylation, suggesting that the role of H2Bub is to induce allosteric rearrangements of the subunit-interaction network within the active site of Set1C that are necessary for methylation activity. Moreover, the interaction between the Set1 N-terminal region and Swd1 renders the Spp1-lacking Set1C competent for H2Bub-dependent H3K4 methylation. Collectively, our results suggest that H2Bub induces conformational changes in Set1C that support H3K4 methylation activity.
title: Dr. Johann Adam Pupikofer
title: 1797-1882
titleType: Subtitle
Creators: name: Christinger, Jakob
Publisher: name: J. Herzog
Year: 1882
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Pupikofer, Johann Adam
subject: Wängi (Thurgau)
subject: Frauenfeld
subject: Gemeinnützige Gesellschaft des Kantons Thurgau

description: Separatabdruck aus der Schweizerischen Zeitschrift für Gemeinnützigkeit, Jahrgang 1882
The Future of Personalised Medicine. Short scenarios
Creators: name: Kienegger, Manuela
name: Giesecke, Susanne
Publisher: name: Zenodo
Year: 2022
Subjects: Scenarios, personalised medicine, HEcoPerMed

description: To demonstrate the value of state-of-the art economic modelling and appropriate financial agreements,
 HEcoPerMed has created future scenarios that consider, on the one hand, the trends, and drivers, and, on
 the other hand, the challenges, and benefits of personalised medicine for the European social model of
 healthcare and its financial viability. Short versions of scenarios are taken from: Giesecke, S., Kienegger, M. (2020). Scenario Development
 - Overview of major findings from workshops and interviews.
 HEcoPerMed Project Deliverable 4.1.
Characterizing the infrared spectra of small, neutral, fully dehydrogenated PAHs
Creators: name: Mackie, C. J.
name: Peeters, E.
name: Bauschlicher, C. W.
name: Cami, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the results of a computational study to investigate the infrared spectroscopic properties of a large number of polycyclic aromatic hydrocarbon (PAH) molecules and their fully dehydrogenated counterparts. We constructed a database of fully optimized geometries for PAHs that is complete for eight or fewer fused benzene rings, thus containing 1550 PAHs and 805 fully dehydrogenated aromatics. A large fraction of the species in our database have clearly non-planar or curved geometries. For each species, we determined the frequencies and intensities of their normal modes using density functional theory calculations. Whereas most PAH spectra are fairly similar, the spectra of fully dehydrogenated aromatics are much more diverse. Nevertheless, these fully dehydrogenated species show characteristic emission features at 5.2$μ$m, 5.5$μ$m and 10.6$μ$m; at longer wavelengths, there is a forest of emission features in the 16--30$μ$m range that appears as a structured continuum, but with a clear peak centered around 19$μ$m. We searched for these features in Spitzer-IRS spectra of various positions in the reflection nebula NGC 7023. We find a weak emission feature at 10.68$μ$m in all positions except that closest to the central star. We also find evidence for a weak 19$μ$m feature at all positions that is not likely due to C$_{60}$. We interpret these features as tentative evidence for the presence of a small population of fully dehydrogenated PAHs, and discuss our results in the framework of PAH photolysis and the formation of fullerenes.
Recognition of the nucleosome by chromatin factors and enzymes
Creators: name: McGinty, R.K.
name: Tan, S.
Publisher: name: Elsevier Ltd
Year: 2016

description: Dynamic expression of the genome requires coordinated binding of chromatin factors and enzymes that carry out genome-templated processes. Until recently, the molecular mechanisms governing how these factors and enzymes recognize and act on the fundamental unit of chromatin, the nucleosome core particle, have remained a mystery. A small, yet growing set of structures of the nucleosome in complex with chromatin factors and enzymes highlights the importance of multivalency in defining nucleosome binding and specificity. Many such interactions include an arginine anchor motif, which targets a unique acidic patch on the nucleosome surface. These emerging paradigms for chromatin recognition will be discussed, focusing on several recent structural breakthroughs.
Pertemuan 2 AKL1 KOMBINASI BISNIS
Creators: name: Dr. Rusdiyanto, SE,. M. Ak,. CH,. CHt
Publisher: name: Zenodo
Year: 2022
Subjects: KOMBINASI BISNIS, AKL 1

description: Capaian Pembelajaran (CP): a. Mahasiswa dapat menjelaskan tujuan dan motivasi kombinasi bisnis b. Mahasiswa dapat menjelaskan konsep pengendalian dan kombinasi bisnis c. Mahasiswa dapat menerapkan pencatatan dan pengukuran transaksi kombinasi bisnis d. Mahasiswa dapat menerapkan penyajian dan pengungkapan kombinasi bisnis A. Kombinasi Bisnis dan Pengendalian Berdasarkan pernyataan standar akuntansi keuangan (PSAK) No. 22 tahun 2015 "Penggabungan usaha (business combination) adalah pernyataan dua atau lebih perusahaan yang terpisah menjadi satu entitas ekonomi karena satu perusahaan menyatu dengan (uniting wiith} perusahaan lain atau memperoleh kendali (control) atas aktiva dan operasi perusahaan lain". Pengendalian yang dimaksud adalah kekuasaan untuk mengatur kebijakan keuangan dan operasi suatu entitas demi memperoleh manfaat dari aktivitas entitas tersebut.Entitas adalah badan yang terpisah dari pemiliknya. Kombinasi bisnis melibatkan 2 pihak yaitu entitas pengakuisisi dan entitas yang diakuisisi.