cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Positive roles for negative regulators in the mating response of yeast
Creators: name: Elston, Timothy C
name: Ford, Eintou
name: Nagiec, Michal J
name: Houser, John R
name: Errede, Beverly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Modeling and experimental analysis of the yeast mating pathway reveals that transcriptional repressor proteins protect a key transcriptional activator from degradation, ensuring that the system is poised to respond rapidly to pheromones and providing a novel mechanism for perfect adaptation.We combine experimentation and mathematical modeling to study the complex interplay between positive and negative regulation of gene expression in the yeast pheromone pathway.The transcriptional repressors Dig1 and Dig2 are shown to have a positive role in mating differentiation by stabilizing the transcriptional activator Ste12. This result was predicted by mathematical modeling and confirmed experimentally.The model also predicts that Ste12 degradation follows saturable kinetics. Again, this observation is confirmed experimentally.The model revealed that stabilization through protein–protein interactions provides a mechanism for robust perfect adaptation and allows the transcriptional response to occur on a time scale that is distinct from upstream signaling events.All cells must detect and respond to changes in their environment, often through changes in gene expression. The yeast pheromone pathway has been extensively characterized, and is an ideal system for studying transcriptional regulation. Here we combine computational and experimental approaches to study transcriptional regulation mediated by Ste12, the key transcription factor in the pheromone response. Our mathematical model is able to explain multiple counterintuitive experimental results and led to several novel findings. First, we found that the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12. This stabilization through protein–protein interactions creates a large pool of Ste12 that is rapidly activated following pheromone stimulation. Second, we found that protein degradation follows saturating kinetics, explaining the long half-life of Ste12 in mutants expressing elevated amounts of Ste12. Finally, our model reveals a novel mechanism for robust perfect adaptation through protein–protein interactions that enhance complex stability. This mechanism allows the transcriptional response to act on a shorter time scale than upstream pathway activity.
Operational considerations on the stability of colliding beams
Creators: name: Buffat, X.
name: Herr, W.
name: Pieloni, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: While well studied in the absence of beam-beam and while colliding head-on, the stability of the LHC beams can be very critical in intermediate steps. During the squeeze, the long-range beam-beam interaction becomes a critical component of the beam's dynamics. Also, while the transverse separation at the interaction points is collapsed, the beam-beam forces change drastically, possibly deteriorating the beam's stability. Finally, during luminosity production, the configuration of the LHC in 2012 included few bunches without head-on collision in any of the interaction points having different stability properties. Stability diagrams are being evaluated numerically in these configurations in an attempt to explain instabilities observed in these phases during the 2012 proton run of the LHC.
description: 5 pages, contribution to the ICFA Mini-Workshop on Beam-Beam Effects in Hadron Colliders, CERN, Geneva, Switzerland, 18-22 Mar 2013
Analysis of Triple-Unit System with Operational Priority
Creators: name: Jyotishree Ghosh
name: D. Pawar
name: S.C. Malik
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Reliability
Non-Identical
Standby
Priority
Semi-Markov
Regenerative Point

description: Reliability of three non-identical unit system is analyzed for various measures. Initially, main unit is operational, one is warm standby and other is cold standby. Single repair facility is present with the system. Operational priority is given to main unit over standby units. Failure times of all the components are exponentially distributed whereas repair time follows Weibull distribution. All the random variables are statistically independent. Semi-Markov process and regenerative point technique are used to analyze mean time to system failure, availability, busy period and expected number of visits by the server. System model’s profit is analyzed for arbitrary values and are shown graphically.
A new continuous probability model based on a trigonometric function: Theory and applications
Creators: name: Hassan, Anwar
name: Murtiza Ali Lone
name: Ishfaq Hassain Dar
name: Ahmad, Peer Bilal
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Sine-G
Exopentiated exponential distribution
Hazard rate function
Order statistic
Simulation study
Maximum likelihood estimation

description: In this manuscript, we highlight a new probability distribution based on a trigonometric function, obtained by specializing the Sine-G family of distributions with exponentiated exponential distribution. The proposed distribution is quite flexible in terms of density and hazard rate functions. Several mathematical properties of the proposed distribution are also explored. For applicability of proposed distribution, two real data sets are scrutinized and it is sensed that proposed distribution leads to a better fit than all other models taken under consideration.
Amino acid degradation by the mesophilic sulfate-reducing bacterium Desulfobacterium vacuolatum
Creators: name: Rees, Gavin N
name: Harfoot, Christopher G
name: Sheehy, Alan J
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Desulfobacterium vacuolatum strain IbRM wasable to grow using casamino acids as a source of carbon,energy and nitrogen. Growth was accompanied by utilizationof several amino acids and sulfide production. Prolineand glutamate were used preferentially and to thegreatest extent. Glycine, serine and alanine were usedmore slowly and only after proline and glutamate wereused. Isoleucine, valine, leucine and aspartate decreasewas slowest and occurred in a linear fashion throughoutthe growth phase. Amino acids used from casamino acids,excluding aspartate, were also used as single carbon, energyand nitrogen sources. As a single amino acid, aspartatecould only be used as a nitrogen source. Aspartatewas not used as an electron acceptor. No growth occurredon any amino acid in the absence of sulfate. As singlesubstrates, isoleucine, proline and glutamate were oxidizedwithout formation of acetate and with molar yieldsof 13.1, 9.4 and 7.7 g mol–1, respectively.
A NOVEL, RELIABLE, ASPECT-BASED SENTIMENT CLASSIFICATION [NRABSC] FOR DIFFERENT INDUSTRY DOMAINS USING HYBRID DEEP LEARNING MODELS
Creators: name: Dhaval Bhoi
name: Thakkar, Amit
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Aspect Based Sentiment Classification
Performance Reliability Analysis
Deep Learning

description: Customers nowadays are more opinionated than they have ever been. They appreciate interacting with industries or businesses and providing feedback like positive, neutral and negative. Customers leave a plethora of information every time they connect with a company, whether it is through a mention or a review, letting businesses know what they are doing well and wrong. However, wading through all of this data by hand may be laborious task. Aspect-based sentiment analysis, on the other hand, can assist you in overcoming this issue. Because of their inherent competency in the semantic synchronization among aspects with associated contextual terms, attention mechanisms and Convolutional Neural Networks (CNNs) are often utilized for aspect-based sentiment categorization. However, because these models lack a mechanism for accounting for important syntactical restrictions and long-range word dependencies, they may incorrectly identify syntactically irrelevant contextual terms as hints for determining aspect emotion. To solve this problem, we suggest establishing a Graph Convolutional Network (GCN) over a sentence’s dependency tree, which is generated using bidirectional Long Short Term Memory (Bi-LSTM). A new aspect-specific sentiment categorization system is proposed as a result of it. Studies on several testing sets show how our suggested approach is on par with a number of state-of-the-art deep learning models in terms of reliable performance efficacy, and that the graph convolution structure appropriately captures both syntactic and semantic data and lengthy-term associations to perform reliable sentiment classification based on the aspects present in the review sentences.
Aquatic invertebrates of Lake Gregory, northwestern Australia, in relation to salinity and ionic composition
Creators: name: Halse, S. A
name: Shiel, R. J
name: Williams, W. D
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Lake Gregory is a large semi-permanent lake system in arid north-western Australia. Its catchment extends intohumid areas and as a result the lake has dried only twice in the last 25 years. Although the system is mostly fresh,parts of it become saline as they dry.We identified aquatic invertebrates and undertook chemical analysis of watersamples from several sites at Lake Gregory in 1989, when the main water-body was saline, and in 1991 and 1993,after the system had flooded and was fresh. During the period 1989–1993, salinities varied from 0.1hto 82h, andionic composition ranged from strong sodium chloride dominance, in saline water and fresh water of the easternpart of the system, to bicarbonate dominance in fresh water of the western area. At least 174 invertebrate specieswere recorded, including two mollusc species that were never collected live. This species richness is much higherthan that recorded from other Australian arid zone lakes, probably owing to long periods of inundation with freshwater. The fauna was dominated by insects (42 per cent of total species richness), crustaceans (27 per cent) androtifers (22 per cent). Most species (160) were restricted to fresh water; only 12 species were found in salinewater. Only one ostracod occurred in saline conditions, although ostracods are a dominant group in Australiansaline lakes. Among species restricted to fresh water, the proportion of rotifer and protozoan fauna that occurred inbicarbonate-dominated water was greater than the proportion of insect, crustacean and hydracarine fauna that didso.
Regularity properties and Rokhlin dimension for compact group actions
Creators: name: Gardella, Eusebio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 46L55, 46L35

description: We show that formation of crossed products and passage to fixed point algebras by compact group actions with finite Rokhlin dimension preserve the following regularity properties: finite decomposition rank, finite nuclear dimension, and tensorial absorption of the Jiang-Su algebra, the latter in the formulation with commuting towers.
description: 18 pages. This preprint contains the material on crossed products in the first version of arXiv:1407.1277
A Numerical Study of the Damage Mechanisms of the Specimens (SENT, SENB, CT, and DENT) used for P265 GH steel
Creators: name: Lahlou, Mohammed
name: Saadouki, Bouchra
name: Abderrazak En-Naji
name: Majid, Fatima
name: Mouhib, Nadia
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Pressure vessels
Finite element model
Mechanical behaviors
Damage
Tensile test
Maintenance

description: During operation, most mechanical structures are subjected to time-varying stresses, which leads to their failure of serious accidents. The lifetime of a mechanical structure is broken down into three stages: stage I; the initiation, stage II; the slow propagation and stage III; the brutal propagation. The objective of this paper is to determine the damage and the lifetime of a pressure equipment by establishing a numerical modeling by finite elements on different specimens (SENT, SENB, DENT, CT) using the calculation code CASTEM. The material studied is P265GH steel commonly used as boiler plate and pressure vessels. The results show that the damage severity of the SENT specimen is more important, followed by the DENT specimen, then the CT specimen and finally SENB.
Bright Extragalactic ALMA Redshift Survey (BEARS) III: Detailed study of emission lines from 71 Herschel targets
Creators: name: Hagimoto, M.
name: Bakx, T. J. L. C.
name: Serjeant, S.
name: Bendo, G. J.
name: Urquhart, S. A.
name: Eales, S.
name: Harrington, K. C.
name: Tamura, Y.
name: Umehata, H.
name: Berta, S.
name: Cooray, A. R.
name: Cox, P.
name: De Zotti, G.
name: Lehnert, M. D.
name: Riechers, D. A.
name: Scott, D.
name: Temi, P.
name: van der Werf, P. P.
name: Yang, C.
name: Amvrosiadis, A.
name: Andreani, P. M.
name: Baker, A. J.
name: Beelen, A.
name: Borsato, E.
name: Buat, V.
name: Butler, K. M.
name: Dannerbauer, H.
name: Dunne, L.
name: Dye, S.
name: Enia, A. F. M.
name: Fan, L.
name: Gavazzi, R.
name: Gonzalez-Nuevo, J.
name: Harris, A. I.
name: Herrera, C. N.
name: Hughes, D. H.
name: Ismail, D.
name: Ivison, R. J.
name: Jones, B.
name: Kohno, K.
name: Krips, M.
name: Lagache, G.
name: Marchetti, L.
name: Massardi, M.
name: Messias, H.
name: Negrello, M.
name: Neri, R.
name: Omont, A.
name: Perez-Fournon, I.
name: Sedgwick, C.
name: Smith, M. W. L.
name: Stanley, F.
name: Verma, A.
name: Vlahakis, C.
name: Ward, B.
name: Weiner, C.
name: Weiss, A.
name: Young, A. J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyse the molecular and atomic emission lines of 71 bright Herschel-selected galaxies between redshifts 1.4 to 4.6 detected by the Atacama Large Millimetre/submillimetre Array. These lines include a total of 156 CO, [C I], and H2O emission lines. For 46 galaxies, we detect two transitions of CO lines, and for these galaxies we find gas properties similar to those of other dusty star-forming galaxy (DSFG) samples. A comparison to photo-dissociation models suggests that most of Herschel-selected galaxies have similar interstellar medium conditions as local infrared-luminous galaxies and high-redshift DSFGs, although with denser gas and more intense far-ultraviolet radiation fields than normal star-forming galaxies. The line luminosities agree with the luminosity scaling relations across five orders of magnitude, although the star-formation and gas surface density distributions (i.e., Schmidt-Kennicutt relation) suggest a different star-formation phase in our galaxies (and other DSFGs) compared to local and low-redshift gas-rich, normal star-forming systems. The gas-to-dust ratios of these galaxies are similar to Milky Way values, with no apparent redshift evolution. Four of 46 sources appear to have CO line ratios in excess of the expected maximum (thermalized) profile, suggesting a rare phase in the evolution of DSFGs. Finally, we create a deep stacked spectrum over a wide rest-frame frequency (220-890 GHz) that reveals faint transitions from HCN and CH, in line with previous stacking experiments.
description: 30 pages, 17 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal. Comments are warmly welcomed
Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis
Creators: name: Mukhtar, M. S.
name: Temp, U.
name: Hahn, M. G.
name: Tan, M.
name: Moriyama, E. N.
name: Mudgil, Y.
name: Booker, K. S.
name: Molina, A.
name: Fulk, B.
name: Seta, S.
name: McCann, M. C.
name: Jorda, L.
name: Pattathil, S.
name: Jiang, K.
name: Frick-Cheng, A.
name: Lorek, J.
name: Friedman, E. J.
name: Schwarz, J.
name: Augustin, K.
name: Botella, J. R.
name: Urano, D.
name: Carr, T.
name: Liu, C.
name: Klopffleisch, K.
name: Kruppe, L.
name: Welter, B.
name: Cooke, T. R.
name: Phan, N.
name: Chen, J.-G.
name: Trusov, Y.
name: Carpita, N. C.
name: Bayne, R. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Yeast two-hybrid technology is used to build a high-quality protein interaction network centered on Arabidopsis G-protein coupled signaling. The interactions uncovered are without precedent in animals and fungi and help identify new cellular roles for G-protein signaling in plants.The heterotrimeric G-protein complex is minimally composed of Gα, Gβ, and Gγ subunits. In the classic scenario, the G-protein complex is the nexus in signaling from the plasma membrane, where the heterotrimeric G-protein associates with heptahelical G-protein-coupled receptors (GPCRs), to cytoplasmic target proteins called effectors. Although a number of effectors are known in metazoans and fungi, none of these are predicted to exist in their canonical forms in plants. To identify ab initio plant G-protein effectors and scaffold proteins, we screened a set of proteins from the G-protein complex using two-hybrid complementation in yeast. After deep and exhaustive interrogation, we detected 544 interactions between 434 proteins, of which 68 highly interconnected proteins form the core G-protein interactome. Within this core, over half of the interactions comprising two-thirds of the nodes were retested and validated as genuine in planta. Co-expression analysis in combination with phenotyping of loss-of-function mutations in a set of core interactome genes revealed a novel role for G-proteins in regulating cell wall modification.
Therapeutic Liabilities of in Vivo Viral Vector Tropism: Adeno-Associated Virus Vectors, NMDAR1 Antisense, and Focal Seizure Sensitivity
Creators: name: Samulski, R.Jude
name: Ming, Zhen
name: McCown, Thomas J.
name: Haberman, Rebecca P.
name: Snowdy, Stephen
name: Criswell, Hugh E.
name: Breese, George R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The N-methyl-d-aspartic acid (NMDA) receptor provides a potential target for gene therapy of focal seizure disorders. To test this approach, we cloned a 729-bp NMDA receptor (NMDAR1) cDNA fragment in the antisense orientation into adeno-associated virus (AAV) vectors, where expression was driven by either a tetracycline-off regulatable promoter (AAV-tTAK-NR1A) or a cytomegalovirus (CMV) promoter (AAV-CMV-NR1A). After infection of primary cultured cortical neurons with recombinant AAV-tTAK-NR1A, patch clamp studies found a significant decrease in maximal NMDA-evoked currents, indicative of a decrease in the number of NMDA receptors. Similarly, infusion of AAV-tTAK-NR1A (1 μl) into the rat temporal cortex significantly decreased NMDAR1-like immunoreactivity in layer V pyramidal cells. When AAV-tTAK-NR1A vectors were infused into the seizure-sensitive site of the rat inferior collicular cortex, the seizure sensitivity increased significantly over a period of 4 weeks. However, collicular infusion of AAV-CMV-NR1A vectors caused the opposite effect, a significant decrease in seizure sensitivity. Subsequent collicular coinfusion of vector encoding green fluorescent protein (GFP) driven by the tetracycline-off promoter (AAV-tTAK-GFP) and vector encoding β-galactosidase driven by the CMV promoter (AAV-CMV-LacZ) transduced distinct neuronal populations with only partial overlap. Thus, differing transduction ratios of inhibitory interneurons to primary output neurons likely account for the divergent seizure influences. Although AAV vector-derived NMDAR1 antisense can influence NMDA receptor function both in vitro and in vivo, promoter-related tropic differences dramatically alter the physiological outcome of this receptor-based gene therapy.
Integrated Self-Inactivating Lentiviral Vectors Produce Full-Length Genomic Transcripts Competent for Encapsidation and Integration
Creators: name: Haas, D. L.
name: Logan, A. C.
name: Kohn, D. B.
name: Kafri, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: To make human immunodeficiency virus type 1 (HIV-1)-based vectors safer for use in the research and clinical setting, a significant modification to the HIV-1 genome has been the deletion of promoter and enhancer elements from the U3 region of the long terminal repeat (LTR). Vectors containing this deletion are thought to have no LTR-directed transcription and are called self-inactivating (SIN) lentivectors. Using four distinct approaches, we show that SIN lentivectors continue to have promoter activity near the 5′ LTR, which is responsible for the production of full-length vector transcripts. To verify that transcripts derived from the LTR in SIN lentivectors are competent for encapsidation and integration, we transduced a lentiviral packaging cell line with a SIN lentivector and then observed the production of viable vector particles containing full-length SIN lentivector genomes. We have also attempted to identify sequences in the SIN lentivector which are responsible for transcriptional activation at the 5′ LTR. Using different segments of the vector LTR and leader region in a promoter assay, we have determined that the residual promoter activity is contained entirely within the leader region and that, although this element is downstream of the transcription initiation site, it is capable of initiating transcription from the 5′ end of R in the LTR. Mutation of leader region binding sites for the transcriptional activators downstream binding factor 1 (DBF1) and SP1 reduces transcription from the SIN LTR by up to 80%. Knowledge of the potential for mobilization of HIV-1-derived SIN lentivectors will be important for the design of future gene therapy trials with such vectors.
A QUASI SUJA DISTRIBUTION
Creators: name: Shanker, Rama
name: Upadhyay, Reshma
name: Shukla, Kamlesh Kumar
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Suja distribution
Statistical Properties
parameters estimation
Goodness of fit

description: A two-parameter quasi Suja distribution which contains Suja distribution as particular case has been proposed for extreme right skewed data. Its statistical properties including moments, skewness, kurtosis, hazard rate function, mean residual life function, stochastic ordering, mean deviations, Bonferroni and Lorenz curves, Renyi entropy measures, and stress-strength reliability have been derived and studied. The estimation of parameters using method of moments and maximum likelihood has been discussed. A simulation study has been presented to know the performance of maximum likelihood estimation. The goodness of fit of the proposed distribution has been presented.
The B & V Light Curves for Recurrent Nova T CrB From 1842--2022, the Unique Pre- and Post-Eruption High-States, the Complex Period Changes, and the Upcoming Eruption in 2025.5$\pm$1.3
Creators: name: Schaefer, Bradley E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: T CrB is one of the most-famous and brightest novae known, and is a recurrent nova with prior eruptions in 1866 and 1946 that peak at $V$=2.0. I have constructed light curves spanning 1842--2022 with 213,730 magnitudes, where the $B$ and $V$ magnitudes are fully corrected to the Johnson system. These light curves first reveal a unique complex high-state (with 20$\times$ higher accretion rate than the normal low-state) stretching from -10 to +9 years after eruption, punctuated with a deep pre-eruption dip (apparently from dust formation in a slow mass ejection) and a unique enigmatic secondary eruption (with 10 per cent of the energy of the primary eruption), with the light curves identical for the 1866 and 1946 eruptions. Starting in 2015, T CrB entered the high-state, like in 1936, so a third eruption in upcoming years has been widely anticipated. With the pre-1946 light curve as a template, I predict a date of 2025.5$\pm$1.3 for the upcoming eruption, with the primary uncertainty arising from a possible lengthening of the pre-eruption high-state. I use the large-amplitude ellipsoidal modulation to track the orbital phase of the binary from 1867--2022. I measure that the orbital period increased abruptly by $+$0.185$\pm$0.056 days across the 1946 eruption, the 1947--2022 years had a steady period decrease of ($-$8.9$\pm$1.6)$\times$10$^{-6}$ days-per-day, and the 1867--1946 years had a steady period change consistent with zero, at ($+$1.75$\pm$4.5)$\times$10$^{-6}$ days-per-day. These large period changes cannot be explained by any published mechanism.
description: MNRAS in press
Delivery of MDR1 Small Interfering RNA by Self-Complementary Recombinant Adeno-Associated Virus Vector
Creators: name: Samulski, R.J.
name: Xu, Dong
name: Fernandes, Alda
name: Fisher, Michael
name: McCarty, Doug
name: Juliano, R.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Small interfering RNAs (siRNAs) are potentially powerful tools for therapeutic gene regulation. DNA cassettes encoding RNA polymerase III promoter-driven hairpin siRNAs allow long-term expression of siRNA in targeted cells. A variety of viral vectors have been used to deliver such cassettes to cells. Here we report on the development and use of a self-complementary recombinant adeno-associated virus (scAAV) vector for siRNA delivery into mammalian cells. We demonstrate that this modified vector efficiently delivers siRNA into multidrug-resistant human breast and oral cancer cells and suppresses MDR1 gene expression. This results in rapid, profound, and durable reduction in the expression of the P-glycoprotein multidrug transporter and a substantial reversion of the drug-resistant phenotype. This research suggests that scAAV-based vectors can be very effective agents for efficient delivery of therapeutic siRNA.
Multiwavelength study of radio galaxy Pictor A: detection of western hotspot in far-UV and possible origin of high energy emissions
Creators: name: Gulati, Sanna
name: Bhattacharya, Debbijoy
name: Ramadevi, M. C.
name: Stalin, C. S.
name: Sreekumar, P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A comprehensive study of the nucleus and western hotspot of Pictor A is carried out using AstroSat observations, 13 years of Fermi, and archival Swift observations, along with other published data. We report the first detection of the western hotspot of Pictor A in the far-UV band using observations from AstroSat-UVIT. The broad-band SED of the western hotspot is explained by a multizone emission scenario where X-ray emission is caused by synchrotron emission process in the substructures embedded in the diffuse region, while the emission in radio to optical is caused by synchrotron emission process in the diffuse region. We do not notice any excess in the IR band and an additional zone (beyond 2-zone) is not required to account for the X-ray emission. Our broad-band spectro-temporal study and associated modelling of the core and hotspot of Pictor A suggests that (a) gamma-rays originate in the nuclear jet and not from the hotspot (b) X-ray emission from the core of Pictor A has nuclear jet-origin instead of previously reported disk-origin.
description: 11 pages, 4 figures, Accepted for publication in MNRAS
Rokhlin dimension for compact group actions
Creators: name: Gardella, Eusebio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: Dynamical Systems (math.DS)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46L55 (Primary), 37B05, 46L35 (Secondary)

description: We introduce and systematically study the notion of Rokhlin dimension (with and without commuting towers) for compact group actions on $C^*$-algebras. This notion generalizes the one introduced by Hirshberg, Winter and Zacharias for finite groups, and contains the Rokhlin property as the zero dimensional case. We show, by means of an example, that commuting towers cannot always be arranged, even in the absence of $K$-theoretic obstructions. For a compact Lie group action on a compact Hausdorff space, freeness is equivalent to finite Rokhlin dimension of the induced action. We compare the notion of finite Rokhlin dimension to other existing definitions of noncommutative freeness for compact group actions. We obtain further $K$-theoretic obstructions to having an action of a non-finite compact Lie group with finite Rokhlin dimension with commuting towers, and use them to confirm a conjecture of Phillips.
description: 31 pages. Section 5 in the old version has been moved to a separate preprint. Some material has been added
A Two Non-Identical Unit Parallel System with Repair and Post Repair Policies of a Failed Unit and Correlated Lifetimes
Creators: name: Chaudhary, Pradeep
name: Surbhi Masih
name: Gupta, Rakesh
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Transition probabilities
mean sojourn time
bi-variate exponential distribution
regenerative point
reliability
MTSF
availability
expected busy period of repairman
net expected profit

description: The paper deals with the analysis of a system model consisting of two non-identical units arranged in a parallel configuration. If a unit fails it goes to repair. After its repair, the repaired unit is sent for post repair to complete its repair. A single repairman is always available with the system to repair a failed unit and for post repair of repaired unit. A post repaired unit always works as good as new. Failure time of both the units is assumed to be correlated random variables having their joint distribution as bivariate exponential (B.V.E.). The repair time distribution of both the units are taken as general with different c.d.fs whereas the post repair time distribution of both the units are taken as exponential with different parameters.
Conference Program and Online Proceedings of the Irish Machine Vision and Image Processing Conference 2023
Creators: name: Corcoran, Peter
name: Farooq, Muhammad Ali
name: Schukat, Michael
Publisher: name: Zenodo
Year: 2023

description: We have an exciting program at this conference that will allow members to reflect upon and celebrate our past accomplishments, renew friendships and extend our networks, and jointly explore current and future research directions. We hope that you will have a productive and fun‐filled time at this very special conference. As part of the 25th anniversary of IMVIP, this year we have added an extra day of Special Sessions and Training activities the day before the main conference. In line with recent developments in the field these special sessions will explore new and emerging topics in the field of Machine Vision and Image Processing. Thus we have sessions on Data Generation and Augmentation, Deep Learning in Medical Image Processing, and Immersive Technologies for Health & User Experience. Thanks to all of our special session chairs for the work involved in organising these sessions. We finish this first day with a 4th special session exploring the challenges presented to Machine Vision systems by recent regulatory developments in Data Privacy laws. This will be followed by an expert panel session to further explore emerging Machine Vision Privacy Challenges. The main conference will open with a Keynote talk from the CTO of Xperi Corporation who will talk about Driver Monitoring Systems and Next-Generation Perceptual AI. Xperi is a global leader in driver monitoring technologies and consumer technologies and this talk will provide useful insights into how industry is adopting state-of-the-art machine vision systems in tomorrow’s products and services. Over the next two days we have 8 themed sessions of oral presentations and two additional sessions featuring more than 20 poster presentations. The detailed conference presentation is provided below with links online to each paper presented at the event. We also provide DOI links to papers published in the conference online community (IMVIP 2023) at zenodo.org. Some papers may include additional datasets or code in the Zenodo archive. The official proceedings for IMVIP 2023 will be available in a month or so at the IPRCS website.
L(2,1)-labelling of Circular-arc Graph
Creators: name: Paul, Satyabrata
name: Pal, Madhumangal
name: Pal, Anita
Publisher: name: arXiv
Year: 2014
Subjects: subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences

description: An L(2,1)-labelling of a graph $G=(V, E)$ is $λ_{2,1}(G)$ a function $f$ from the vertex set V (G) to the set of non-negative integers such that adjacent vertices get numbers at least two apart, and vertices at distance two get distinct numbers. The L(2,1)-labelling number denoted by $λ_{2,1}(G)$ of $G$ is the minimum range of labels over all such labelling. In this article, it is shown that, for a circular-arc graph $G$, the upper bound of $λ_{2,1}(G)$ is $Δ+3ω$, where $Δ$ and $ω$ represents the maximum degree of the vertices and size of maximum clique respectively.
description: 12 pages
Age-Divided Mean Stellar Populations from Full Spectrum Fitting as the Simplified Star Formation and Chemical Evolution History of a Galaxy: Methodology and Reliability
Creators: name: Lee, Joon Hyeop
name: Pak, Mina
name: Jeong, Hyunjin
name: Oh, Sree
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We introduce a practical methodology for investigating the star formation and chemical evolution history of a galaxy: age-divided mean stellar populations (ADPs) from full spectrum fitting. In this method, the mass-weighted mean stellar populations and mass fractions (f_mass) of young and old stellar components in a galaxy are separately estimated, which are divided with an age cut (selected to be 10^9.5 yr ~ 3.2 Gyr in this paper). To examine the statistical reliability of ADPs, we generate 10,000 artificial galaxy spectra, each of which consists of five random simple stellar population components. Using the Penalized PiXel-Fitting (pPXF) package, we conduct full spectrum fitting to the artificial spectra with noise as a function of wavelength, imitating the real noise of Sydney-Australian Astronomical Observatory Multi-object Integral field spectrograph (SAMI) galaxies. As a result, the Δ(= output - input) of age and metallicity appears to significantly depend on not only signal-to-noise ratio (S/N), but also luminosity fractions (f_lum) of young and old components. At given S/N and f_lum, Δof young components tends to be larger than Δof old components; e.g., σ(Δ[M/H]) ~ 0.40 versus 0.23 at S/N = 30 and f_lum = 50 per cent. The age-metallicity degeneracy appears to be insignificant, but Δlog(age/yr) shows an obvious correlation with Δf_mass for young stellar components (R ~ 0.6). The impact of dust attenuation and emission lines appears to be mostly insignificant. We discuss how this methodology can be applied to spectroscopic studies of the formation histories of galaxies, with a few examples of SAMI galaxies.
description: 26 pages, 24 figures, accepted for publication in MNRAS
DISCRETE-TIME WORKING VACATIONS QUEUE WITH IMPATIENT CLIENTS AND CONGESTION DEPENDENT SERVICE RATES
Creators: name: K. Jyothsna
name: P.K. Jyothsna
name: P. Vijaya Kumar
name: Ch. Gopala Rao
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Queue
discrete-time
working vacations
balking
reneging
congestion dependent service rates

description: The current research article explores a finite capacity discrete-time multiple working vacations queue with impatient clients and congestion dependent service rates. An arriving client can choose either to enter the queue or balk with a certain probability. Due to impatience, he may renege after joining the queue as per geometric distribution. Rather than totally shutting down the service throughout the vacation period, the server functions with a different service rate. The times of services during regular service and during working vacation periods are considered to be geometrically distributed. The vacation periods are also presumed to be geometrically distributed. In addition, the service rates are considered to be dependent on the number of clients in the system during regular service period and during working vacation period. The model’s steady-state probabilities are calculated using matrix approach and a recursive solution is also provided. The recursive solution is used for obtaining the corresponding continuous-time results. Various system performance metrics are presented. Finally, the numerical representation of the consequences of the model parameters on the performance metrics is furnished.
The Enhancing Effects of the Light Chain on Heavy Chain Secretion in Split Delivery of Factor VIII Gene
Creators: name: Liu, Xiang-Qin
name: Pierce, Glenn F
name: Arruda, Valder R
name: Sarkar, Rita
name: Xiao, Weidong
name: Wang, Xuefeng
name: Lu, Hui
name: Pipe, Steven W
name: Camire, Rodney M
name: Chen, Lingxia
name: Jiang, Haiyan
name: Wang, Jinhui
name: Xiao, Xiao
name: Zhao, Jennifer
name: Ding, Qiulan
name: Li, Juan
name: Zhu, Fuxiang
name: Wang, Hongli
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Coagulation factor VIII (FVIII) is secreted as a heterodimer consisting of a heavy chain (HC) and a light chain (LC), which can be expressed independently and reassociate with recovery of biological activity. Because of the size limitation of adeno-associated virus (AAV) vectors, a strategy for delivering the HC and LC separately has been developed. However, the FVIII HC is secreted 10–100-fold less efficiently than the LC. In this study, we demonstrated that the F309S mutation and enhanced B-domain glycosylations alone are not sufficient to improve FVIII HC secretion, which suggested a role of the FVIII LC in regulating HC secretion. To characterize this role of the FVIII LC, we compared FVIII HC secretion with and without the LC via post-translational protein trans-splicing. As demonstrated in vitro, ligation of the LC to the HC significantly increased HC secretion. Such HC secretion increases were also confirmed in vivo by hydrodynamic injection of FVIII intein plasmids into hemophilia A mice. Moreover, similar enhancement of HC secretion can also be observed when the LC is supplied in trans, which is probably due to the spontaneous association of the HC and the LC in the secretion pathway. In sum, enhancing the secretion of the FVIII HC polypeptide may require the proper association of the FVIII LC polypeptide in cis or in trans. These results may be helpful in designing new strategies to improve FVIII gene delivery.
EPQ MODELS WITH GENERALIZED PARETO RATE OF PRODUCTION AND WEIBULL DECAY HAVING DEMAND AS FUNCTION OF ON HAND INVENTORY
Creators: name: D. Madhulatha
name: K. Srinivasa Rao
name: B. Muniswamy
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Stochastic production
on hand inventory
Weibull decay
Generalized Pareto distribution
Production Schedules
Sensitivity analysis

description: Economic production quantity (EPQ) models are more important for scheduling production processes in particular batch production in which the production uptime and production downtime are decision variables. This paper addresses the development and analysis of an EPQ model with random production and Weibull decay having stock dependent demand. The random production is more appropriate in several production processes dealing with deteriorated items. The instantaneous state of on hand inventory is derived. With appropriate cost considerations the total cost function is derived and minimized for obtaining optimal production uptime, production downtime and production quantity. The model sensitivity with respect to changes in parameters and costs is also studied and observe that the production distribution parameters and deteriorating distribution parameters have significant influence on optimal operating policies of the model. This model is extended to the case of without shortages and observed that allowing shortages reduce total product cost. It is further observed that the demand being a function of on hand inventory can reduce inventory cost than other patterns of demand.
Aquatic microfauna from Lake Catani and environs, Mount Buffalo National Park
Creators: name: Shiel, Russ
name: Griggs, Jackie
Publisher: name: La Trobe
Year: 2023

description: MDFRC item.

Zooplankton-net trawls from Mount Buffalo reservoir, Lake Catani, and five streams in the surrounding area yielded 75 taxa of microfauna (testate rhizopods, rotifers, microcrustacea) and eight taxa of small macroinvertebrates. Most taxa are new records for the National Park. At least seven testates and one rotifer apparently are new records for Australia. Of seven sites sampled, Lake Catani had the most diverse microfauna (31 taxa), otherwise species diversity was low. There was little similarity in microfaunal assemblages between sites.
A Large U3 Deletion Causes Increased In Vivo Expression From a Nonintegrating Lentiviral Vector
Creators: name: Ma, Hong
name: Bayer, Matthew
name: Zeithaml, Brian
name: Kantor, Boris
name: Kafri, Tal
name: Cockrell, Adam
name: Li, Xiangping
name: McCown, Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The feasibility of employing nonintegrating lentiviral vectors has been demonstrated by recent studies showing the ability of nonintegrating lentiviral vectors to maintain transgene expression in vitro and in vivo. Furthermore, HIV-1 vectors packaged with a mutated integrase were able to correct retinal disease in a mouse model. Interestingly, these results differ from earlier studies in which first-generation nonintegrating lentiviral vectors yielded insignificant levels of transduction. However, to date a rigorous characterization of transgene expression from the currently used self-inactivating (SIN) nonintegrating lentiviral vectors has not been published. Here we characterize transgene expression from SIN nonintegrating lentiviral vectors. Overall, we found that nonintegrating vectors express transgenes at a significantly lower level than their integrating counterparts. Expression from nonintegrating vectors was improved upon introducing a longer deletion in the vector’s U3 region. A unique shuttle-vector assay indicated that the relative abundance of the different episomal forms was not altered by the longer U3 deletion. Interestingly, the longer U3 deletion did not enhance expression in the corpus callosum of the rat brain, suggesting that the extent of silencing of episomal transcription is influenced by tissue-specific factors. Finally, and for the first time, episomal expression in the mouse liver was potent and sustained.
Advection-dominated accretion flow for the varied transition luminosities in black hole X-ray binaries
Creators: name: Li, Jiaqi
name: Qiao, Erlin
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Observationally, two main spectral states, i.e., the low/hard state and the high/soft state, are identified in black hole X-ray binaries (BH-XRBs). Meanwhile, the transitions between the two states are often observed. In this paper, we re-investigate the transition luminosities in the framework of the self-similar solution of the advection-dominated accretion flow (ADAF). Specifically, we search for the critical mass accretion rate $\dot m_{\rm crit}$ of ADAF for different radii $r$ respectively. It is found that $\dot m_{\rm crit}$ decreases with decreasing $r$. By testing the effects of BH mass $m$, the magnetic parameter $β$ and the viscosity parameter $α$, it is found that only $α$ has significant effects on $\dot m_{\rm crit}-r$ relation. We define the minimum $\dot m_{\rm crit}$ (roughly at the innermost stable circular orbit) as the hard-to-soft transition rate $\dot m_{\rm tr: H\rightarrow S}$, above which BH will gradually transit from the low/hard state to the high/soft state, and $\dot m_{\rm crit}$ at $30$ Schwarzschild radii as the soft-to-hard transition rate $\dot m_{\rm tr: S\rightarrow H}$, below which BH will gradually transit from the high/soft state to the low/hard state. We derive fitting formulae of $\dot m_{\rm tr: H\rightarrow S}$ and $\dot m_{\rm tr: S\rightarrow H}$ as functions of $α$ respectively. By comparing with observations, it is found that the mean value of $α$ are $α\sim 0.85$ and $α\sim 0.33$ for the hard-to-soft transition and the soft-to-hard transition respectively, which indicates that two classes of $α$ are needed for explaining the hysteresis effect during the state transition. Finally, we argue that such a constrained $α$ may provide valuable clues for further exploring the accretion physics in BH-XRBs.
description: 10 pages, 7 figures, 4 tables, accepted for publication in MNRAS
ESTIMATION AND TESTING PROCEDURES OF P(Y < X) FOR THE INVERSE DISTRIBUTIONS FAMILY UNDER TYPE-II CENSORING
Creators: name: Chauhan, Kuldeep Singh
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Inverse distributions family
testing procedur es
bootstrap sampling

description: We recommended an inverse distributions family. The challenge of estimating R(t) and P in type-II censoring was measured to produce Uniformly Minimum Variance Unbiased Estimator (UMVUE) and Maximum Likelihood Estimator (MLE). The estimators have been created for R(t) and P.Testing approaches for R(t) and P under type-II censoring have been constructed for hypotheses associated with various parametric functions. The author provides an alternate method for generating these estimators.A comparative assessment of two estimating techniques has been conducted. The simulation technique has been used to assess the performance of estimators.
AAV8-mediated Gene Transfer of Interleukin-4 to Endogenous β-Cells Prevents the Onset of Diabetes in NOD Mice
Creators: name: Trucco, Massimo
name: Robbins, Paul D
name: Xiao, Xiao
name: Rehman, Khaja K
name: Wang, Zhong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We previously demonstrated that intra-peritoneal delivery of adeno-associated virus serotype 8 (AAV8) stably transduces the pancreas, including the β-cells in the endogenous islets. We also demonstrated the ability to deliver and express genes specifically in β-cells for at least 6 months using a murine insulin promoter (mIP) in a double-stranded, self-complementary AAV vector (dsAAV8-mIP). Here we evaluated the effects of dsAAV8-mIP mediated delivery of interleukin 4 (mIL-4) to endogenous β-cells in NOD mice. In 4 week old NOD mice, the extent of gene transfer and expression in endogenous β-cells following i.p. delivery of dsAAV8-mIP-eGFP was comparable to normal BALB/c mice. Furthermore, following i.p. delivery of dsAAV8-mIP-IL4, expression of mIL-4 was detected in islets isolated and cultured from the treated mice. AAV8-mIP mediated gene expression of mIL-4 to endogenous β-cells of 4 and 8 week old NOD mice prevented the onset of hyperglycemia in NOD mice and reduced the severity of insulitis. Moreover, expression of mIL-4 also maintained the level of CD4+CD25+FoxP3+ cells and adoptive co-transfer of splenocytes from diabetes-free IL-4 vector recipients and splenocytes from wild type diabetic NOD mice prevented the onset diabetes. Taken together, these results demonstrate that local expression of mIL-4 in islets prevents islet destruction and blocks autoimmunity, in part, through regulation of T cell function. These results also demonstrate the utility of using dsAAV8-mIP gene transfer to endogenous NOD β-cells to examine the role of specific gene products in preventing or exacerbating the onset of type 1 diabetes.