cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Autism and Increased Paternal Age Related Changes in Global Levels of Gene Expression Regulation
Creators: name: Alter, Mark D.
name: Kharkar, Rutwik
name: Ramsey, Keri E.
name: Craig, David W.
name: Melmed, Raun D.
name: Grebe, Theresa A.
name: Bay, R. Curtis
name: Ober-Reynolds, Sharman
name: Kirwan, Janet
name: Jones, Josh J.
name: Turner, J. Blake
name: Hen, Rene
name: Stephan, Dietrich A.
Publisher: name: Columbia University
Year: 2011
Subjects: subject: Autism--Etiology
subject: DNA microarrays--Data processing
subject: Genetic regulation
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular biology
subject: Medical sciences

description: A causal role of mutations in multiple general transcription factors in neurodevelopmental disorders including autism suggested that alterations in global levels of gene expression regulation might also relate to disease risk in sporadic cases of autism. This premise can be tested by evaluating for changes in the overall distribution of gene expression levels. For instance, in mice, variability in hippocampal-dependent behaviors was associated with variability in the pattern of the overall distribution of gene expression levels, as assessed by variance in the distribution of gene expression levels in the hippocampus. We hypothesized that a similar change in variance might be found in children with autism. Gene expression microarrays covering greater than 47,000 unique RNA transcripts were done on RNA from peripheral blood lymphocytes (PBL) of children with autism (n = 82) and controls (n = 64). Variance in the distribution of gene expression levels from each microarray was compared between groups of children. Also tested was whether a risk factor for autism, increased paternal age, was associated with variance. A decrease in the variance in the distribution of gene expression levels in PBL was associated with the diagnosis of autism and a risk factor for autism, increased paternal age. Traditional approaches to microarray analysis of gene expression suggested a possible mechanism for decreased variance in gene expression. Gene expression pathways involved in transcriptional regulation were down-regulated in the blood of children with autism and children of older fathers. Thus, results from global and gene specific approaches to studying microarray data were complimentary and supported the hypothesis that alterations at the global level of gene expression regulation are related to autism and increased paternal age. Global regulation of transcription, thus, represents a possible point of convergence for multiple etiologies of autism and other neurodevelopmental disorders.
Comment on Partial Adiabatic Quantum Search
Creators: name: Kay, Alastair
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The partial adiabatic search algorithm was introduced in [A. Tulsi, Phys. Rev. A 80, 052328 (2009)] as a modification of the usual adiabatic algorithm for quantum search with the idea that most of the interesting computation only happens over a very short range of the adiabatic path. By focussing on that restricted range, one can potentially gain advantage by reducing the control requirements on the system, enabling a uniform rate of evolution. In this comment, we point out an oversight in the original work [1] that invalidates its proof. However, the argument can be corrected, and the calculations in [1] are then sufficient to show that the scheme still works. Nevertheless, subsequent works [2-6] cannot all be recovered in the same way.
description: 3 pages
The superconformal index and an elliptic algebra of surface defects
Creators: name: Bullimore, Mathew
name: Fluder, Martin
name: Hollands, Lotte
name: Richmond, Paul
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we continue the study of the superconformal index of four-dimensional $\mathcal{N}=2$ theories of class $\mathcal{S}$ in the presence of surface defects. Our main result is the construction of an algebra of difference operators, whose elements are labeled by irreducible representations of $A_{N-1}$. For the fully antisymmetric tensor representations these difference operators are the Hamiltonians of the elliptic Ruijsenaars-Schneider system. The structure constants of the algebra are elliptic generalizations of the Littlewood-Richardson coefficients. In the Macdonald limit, we identify the difference operators with local operators in the two-dimensional TQFT interpretation of the superconformal index. We also study the dimensional reduction to difference operators acting on the three-sphere partition function, where they characterize supersymmetric defects supported on a circle, and show that they are transformed to supersymmetric Wilson loops under mirror symmetry. Finally, we compare to the difference operators that create 't Hooft loops in the four-dimensional $\mathcal{N}=2^*$ theory on a four-sphere by embedding the three-dimensional theory as an S-duality domain wall.
description: 53+16 pages, 12 figures; v2: minor corrections, references added; published version
Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates
Creators: name: Perera, Tarique D.
name: Dwork, Andrew Jay
name: Keegan, Kathryn A.
name: Thirumangalakudi, Lakshmi
name: Lipira, Cecilia M.
name: Joyce, Niamh
name: Lange, Christopher
name: Higley, J. Dee
name: Rosoklija, Gorazd B.
name: Hen, Rene
name: Sackeim, Harold A.
name: Coplan, Jeremy D.
Publisher: name: Columbia University
Year: 2011
Subjects: subject: Fluoxetine
subject: Primates as laboratory animals
subject: Depression, Mental--Research
subject: Developmental neurobiology
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Molecular biology
subject: Mental health

description: Background

Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants. Nonhuman primate (NHP) studies may bridge important rodent findings to the clinical realm since NHP-depression shares significant homology with human depression and kinetics of primate neurogenesis differ from those in rodents. After demonstrating that antidepressants can stimulate neurogenesis in NHPs, our present study examines whether neurogenesis is required for antidepressant efficacy in NHPs.

Materials/Methodology

Adult female bonnets were randomized to three social pens (N = 6 each). Pen-1 subjects were exposed to control-conditions for 15 weeks with half receiving the antidepressant fluoxetine and the rest receiving saline-placebo. Pen-2 subjects were exposed to 15 weeks of separation-stress with half receiving fluoxetine and half receiving placebo. Pen-3 subjects 2 weeks of irradiation (N = 4) or sham-irradiation (N = 2) and then exposed to 15 weeks of stress and fluoxetine. Dependent measures were weekly behavioral observations and postmortem neurogenesis levels.

Results

Exposing NHPs to repeated separation stress resulted in depression-like behaviors (anhedonia and subordinance) accompanied by reduced hippocampal neurogenesis. Treatment with fluoxetine stimulated neurogenesis and prevented the emergence of depression-like behaviors. Ablation of neurogenesis with irradiation abolished the therapeutic effects of fluoxetine. Non-stressed controls had normative behaviors although the fluoxetine-treated controls had higher neurogenesis rates. Across all groups, depression-like behaviors were associated with decreased rates of neurogenesis but this inverse correlation was only significant for new neurons in the anterior dentate gyrus that were at the threshold of completing maturation.

Conclusion

We provide evidence that induction of neurogenesis is integral to the therapeutic effects of fluoxetine in NHPs. Given the similarity between monkeys and humans, hippocampal neurogenesis likely plays a similar role in the treatment of clinical depression. Future studies will examine several outstanding questions such as whether neuro-suppression is sufficient for producing depression and whether therapeutic neuroplastic effects of fluoxetine are specific to antidepressants.
ПСИХОЛОГИЧЕСКИЕ ПРОБЛЕМЫ ФЕНОМЕН ЭМОЦИОНАЛЬНОГО ИНТЕЛЛЕКТА.
Creators: name: Мaxamatqulov, Z.X.
Publisher: name: Zenodo
Year: 2023

description: В данной статье рассматриваются психологические проблемы феномен эмоционального интеллекта. В статье также рассматриваются история создания эмоционального интеллекта, различные концептуальные подходы к эмоциональному интеллекту, взгляды исследователей, психологические процессы, составляющие эмоциональный интеллект, взаимосвязь эмоций и интеллекта, а также роль интеллекта в общении.
Stable ordered structures of binary technetium alloys from first principles
Creators: name: Levy, Ohad
name: Xue, Junkai
name: Wang, Shidong
name: Hart, Gus L. W.
name: Curtarolo, Stefano
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Technetium, element 43, is the only radioactive transition metal. It occurs naturally on earth in only trace amounts. Experimental investigation of its possible compounds is thus inherently difficult and limited. Half of the Tc-transition-metal systems (14 out of 28) are reported to be phase separating or lack experimental data. Using high-throughput first-principles calculations, we present a comprehensive investigation of the binary alloys of technetium with the transition metals. The calculations predict stable, ordered structures in nine of these 14 binary systems. They also predict additional compounds in all nine known compound-forming systems and in two of the five systems reported with disordered \c{hi} or σ phases. These results accentuate the incompleteness of the current knowledge of technetium alloys and should guide experimental studies to obtain accurate structural information on potential compounds, obviating some of the difficulties associated with such work.
Global State Measures of the Dentate Gyrus Gene Expression System Predict Antidepressant-Sensitive Behaviors
Creators: name: McCurdy, Richard D.
name: Dranovsky, Alex
name: Williams, Amanda
name: Leonardo, Eduardo David
name: Samuels, Benjamin A.
name: Hen, Rene
name: Wong, Erik
name: Nesbitt, Addie May I.
name: Alter, Mark
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Dentate gyrus
subject: Fluoxetine
subject: Genetic regulation
subject: Antidepressants--Effectiveness
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Molecular biology
subject: Medical sciences

description: Background

Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common form of medication treatment for major depression. However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems respond to treatments may be critical for understanding antidepressant resistance.

Methods

We take a novel approach to this problem by demonstrating that the gene expression system of the dentate gyrus responds to fluoxetine (FLX), a commonly used antidepressant medication, in a stereotyped-manner involving changes in the expression levels of thousands of genes. The aggregate behavior of this large-scale systemic response was quantified with principal components analysis (PCA) yielding a single quantitative measure of the global gene expression system state.

Results

Quantitative measures of system state were highly correlated with variability in levels of antidepressant-sensitive behaviors in a mouse model of depression treated with fluoxetine. Analysis of dorsal and ventral dentate samples in the same mice indicated that system state co-varied across these regions despite their reported functional differences. Aggregate measures of gene expression system state were very robust and remained unchanged when different microarray data processing algorithms were used and even when completely different sets of gene expression levels were used for their calculation.

Conclusions

System state measures provide a robust method to quantify and relate global gene expression system state variability to behavior and treatment. State variability also suggests that the diversity of reported changes in gene expression levels in response to treatments such as fluoxetine may represent different perspectives on unified but noisy global gene expression system state level responses. Studying regulation of gene expression systems at the state level may be useful in guiding new approaches to augmentation of traditional antidepressant treatments.
Enhancement of laccases thermostability in Betaine based Natural Deep Eutectic Solvents
Creators: name: Varriale, Simona
name: Delorme, Astrid E.
name: Jean-Michel Andanson
name: Verney, Vincent
name: Pezzella, Cinzia
Publisher: name: Zenodo
Year: 2021
Subjects: Laccase
Deep eutectic solvent
Enzyme stability
Molecular docking
Betaine
Polyols

description: In recent years, natural deep eutectic solvents (NADESs) have gained increasing attention as promising non-toxic solvents for biotechnological applications, due to their compatibility with enzymes and ability to enhance the enzyme activity. Betaine - based NADESs at a concentration of 25 wt% in a buffered aqueous solution [1] were used as media to inhibit thermal inactivation of #rPOXA1b and 5 variants laccases when incubated at 70°C and 90°C for 1 hour. All the tested laccases showed higher residual activity when incubated in NADES solutions compared to the enzymes incubated in the reference solution. Furthermore, the residual activity of laccases in presence of NADESs showed a clear advantage over the use of NADESs’ individual components. Molecular docking simulations were performed to better understand the role of NADESs in the stabilization of laccases towards thermal degradation observed in the experimental work. The 3-dimensional structures of the NADES components and #rPOXA1b and 5 variants laccases were built using YASARA Structure software and the effect of mutations on the on the enzyme stability were evaluated. The binding energies between laccases and NADES components were calculated and compared to the experimental results of the measured residual activities. These findings demonstrate the possibility of pre-incubating enzymes in NADESs as a facile and cost-effective solution to inhibit thermal inactivation of enzymes when exposed to high temperatures for various time.
description: {"references": ["Delorme, A. E., Andanson, J.-M., and Verney, V. (2020). Improving laccase thermostability with aqueous natural deep eutectic solvents. Int. J. Biol. Macromol. 163, 919\u2013926. doi.org/10.1016/j.ijbiomac.2020.07.022"]}
Serotonin/Dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout
Creators: name: Sora, Ichiro
name: Hen, Rene
name: Uhl, George R.
name: Hall, Frank Scott
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Dopamine
subject: Cocaine--Physiological effect
subject: Drug interactions
subject: Serotonin--Receptors
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Molecular biology
subject: Medical sciences

description: Knockout (KO) mice that lack the dopamine transporter (SL6A3; DAT) display increased locomotion that can be attenuated, under some circumstances, by administration of drugs that normally produce psychostimulant-like effects, such as amphetamine and methylphenidate. These results have led to suggestions that DAT KO mice may model features of attention deficit hyperactivity disorder (ADHD) and that these drugs may act upon serotonin (5-HT) systems to produce these unusual locomotor decreasing effects. Evidence from patterns of brain expression and initial pharmacologic studies led us to use genetic and pharmacologic approaches to examine the influence of altered 5-HT1B receptor activity on hyperactivity in DAT KO mice. Heterozygous 5-HT1B KO and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in DAT KO mice. Furthermore, DAT KO mice with reduced, but not eliminated, 5-HT1B receptor expression regained cocaine-stimulated locomotion, which was absent in DAT KO mice with normal levels of 5-HT1B receptor expression. Further experiments demonstrated that the degree of habituation to the testing apparatus determined whether cocaine had no effect on locomotion in DAT KO or reduced locomotion, helping to resolve differences among prior reports. These findings of complementation of the locomotor effects of DAT KO by reducing 5-HT1B receptor activity underscore roles for interactions between specific 5-HT receptors and dopamine (DA) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-HT1B antagonists as potential, non-stimulant ADHD therapeutics.
Running rescues a fear-based contextual discrimination deficit in aged mice
Creators: name: Wu, Melody V.
name: Luna, Victor M.
name: Hen, Rene
Publisher: name: Columbia University
Year: 2015
Subjects: subject: Dentate gyrus
subject: Developmental neurobiology
subject: Running--Psychological aspects
subject: Pattern perception
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Aging
subject: Medical sciences

description: Normal aging and exercise exert extensive, often opposing, effects on the dentate gyrus (DG) of the hippocampus altering volume, synaptic function, and behaviors. The DG is especially important for behaviors requiring pattern separation—a cognitive process that enables animals to differentiate between highly similar contextual experiences. To determine how age and exercise modulate pattern separation in an aversive setting, young, aged, and aged mice provided with a running wheel were assayed on a fear-based contextual discrimination task. Aged mice showed a profound impairment in contextual discrimination compared to young animals. Voluntary exercise rescued this deficit to such an extent that behavioral pattern separation of aged-run mice was now similar to young animals. Running also resulted in a significant increase in the number of immature neurons with tertiary dendrites in aged mice. Despite this, neurogenesis levels in aged-run mice were still considerably lower than in young animals. Thus, mechanisms other than DG neurogenesis likely play significant roles in improving behavioral pattern separation elicited by exercise in aged animals.
Additional file 1 of Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis
Creators: name: Meyer, Steffi De
name: Schaeverbeke, Jolien M.
name: Verberk, Inge M. W.
name: Gille, Benjamin
name: Schaepdryver, Maxim De
name: Luckett, Emma S.
name: Gabel, Silvy
name: Bruffaerts, Rose
name: Mauroo, Kimberley
name: Thijssen, Elisabeth H.
name: Stoops, Erik
name: Vanderstichele, Hugo M.
name: Teunissen, Charlotte E.
name: Vandenberghe, Rik
name: Poesen, Koen
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Appendix 1. Conversion of [18F]flutemetamol and [18F]florbetaben SUVR to the Centiloid scale. Supplementary Table 1. Plasma amyloid and tau performance (AUC) differences between platforms and subgroups for detecting amyloid-PET positivity. Supplementary Table 2. Performance of adjusted biomarker models relative to a basic demographic model and unadjusted biomarker models Supplementary Table 3. Sensitivities, specificities, PPVs and NPVs of logistic regression models corrected for age and APOE-ε4 genotype. Supplementary Figure 1. Comparison of ELISA and SIMOA measurements of plasma Aβ1-42/Aβ1-40 and Aβ1-42/t-tau. Supplementary Figure 2. ROC curves of plasma amyloid and tau with amyloid-PET as the standard-of-truth. Supplementary Figure 3. Correlations of ELISA and SIMOA plasma amyloid and tau levels with Centiloids and CSF Aβ1-42/t-tau.
Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice
Creators: name: Masson, Justine
name: Thomsen, Gretchen M.
name: Lin, Chyuan-Sheng
name: Merker, Robert J.
name: Gaisler-Salomon, Inna
name: Wang, Yvonne
name: Ernst, Rachel
name: Hen, Rene
name: Rayport, Stephen G.
name: Gellman, Celia
name: Mingote, Susana
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Glutamic acid
subject: Central nervous system--Effect of drugs on
subject: Schizophrenia--Chemotherapy
subject: Schizophrenia--Treatment
subject: Mental health
subject: Molecular biology
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands. Here for the first time, we have implemented this strategy to address the potential therapeutic value of a glutamate-based pharmacotherapy for schizophrenia involving inhibition of the glutamate recycling enzyme phosphate-activated glutaminase. Mice constitutively heterozygous for GLS1, the gene encoding glutaminase, manifest a schizophrenia resilience phenotype, a key dimension of which is an attenuated locomotor response to propsychotic amphetamine challenge. If resilience is due to glutaminase deficiency in adulthood, then glutaminase inhibitors should have therapeutic potential. However, this has been difficult to test given the dearth of neuroactive glutaminase inhibitors. So, we used genetic pharmacotherapy to ask whether adult induction of GLS1 heterozygosity would attenuate amphetamine responsiveness. We generated conditional floxGLS1 mice and crossed them with global CAGERT2cre∕+ mice to produce GLS1 iHET mice, susceptible to tamoxifen induction of GLS1 heterozygosity. One month after tamoxifen treatment of adult GLS1 iHET mice, we found a 50% reduction in GLS1 allelic abundance and glutaminase mRNA levels in the brain. While GLS1 iHET mice showed some recombination prior to tamoxifen, there was no impact on mRNA levels. We then asked whether induction of GLS heterozygosity would attenuate the locomotor response to propsychotic amphetamine challenge. Before tamoxifen, control and GLS1 iHET mice did not differ in their response to amphetamine. One month after tamoxifen treatment, amphetamine-induced hyperlocomotion was blocked in GLS1 iHET mice. The block was largely maintained after 5 months. Thus, a genetically induced glutaminase reduction—mimicking pharmacological inhibition—strongly attenuated the response to a propsychotic challenge, suggesting that glutaminase may be a novel target for the pharmacotherapy of schizophrenia. These results demonstrate how genetic pharmacotherapy can be implemented to test a CNS target in advance of the development of specific neuroactive inhibitors. We discuss further the advantages, limitations, and feasibility of the wider application of genetic pharmacotherapy for neuropsychiatric drug development.
Improving the sensitivity of a search for coalescing binary black holes with non-precessing spins in gravitational wave data
Creators: name: Privitera, Stephen
name: Mohapatra, Satyanarayan R. P.
name: Ajith, Parameswaran
name: Cannon, Kipp
name: Fotopoulos, Nickolas
name: Frei, Melissa A.
name: Hanna, Chad
name: Weinstein, Alan J.
name: Whelan, John T.
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We demonstrate the implementation of a sensitive search pipeline for gravitational waves from coalescing binary black holes whose components have spins aligned with the orbital angular momentum. We study the pipeline recovery of simulated gravitational wave signals from aligned-spin binary black holes added to real detector noise, comparing the pipeline performance with aligned-spin filter templates to the same pipeline with non-spinning filter templates. Our results exploit a three-parameter phenomenological waveform family that models the full inspiral-merger-ringdown coalescence and treats the effect of aligned spins with a single effective spin parameter χ. We construct template banks from these waveforms by a stochastic placement method and use these banks as filters in the recently-developed gstlal search pipeline. We measure the observable volume of the analysis pipeline for binary black hole signals with total mass in [15,25] solar masses and χin [0, 0.85]. We find an increase in observable volume of up to 45% for systems with 0.2 <= χ<= 0.85 with almost no loss of sensitivity to signals with 0 <= χ<= 0.2. We demonstrate this analysis on 25.9 days of data obtained from the Hanford and Livingston detectors in LIGO's fifth observation run.
description: Submitted to Phys. Rev. D
Family planning in conflict: results of cross-sectional baseline surveys in three African countries
Creators: name: McGinn, Therese J.
name: Lee-Jones, Louise
name: Meyers, Janet
name: Mubiru, Frederick Kintu
name: Schlecht, Jennifer
name: Sharer, Melissa
name: Langston, Anne
name: Amsalu, Ribka
name: Casey, Sara E.
name: Fadulalmula, Shihab Ibrahim
name: Yetter, Mary
name: Anfinson, Katherine
name: Austin, Judy
Publisher: name: Columbia University
Year: 2011
Subjects: Family planning services
Women refugees--Health and hygiene
Reproductive health services
Public health
Epidemiology
Families

description: Background: Despite the serious consequences of conflict for reproductive health, populations affected by conflict and its aftermath face tremendous barriers to accessing reproductive health services, due to insecurity, inadequate numbers of trained personnel and lack of supplies. Family planning is often particularly neglected. Methods: In six conflict-affected areas in Sudan, northern Uganda and the Democratic Republic of Congo, household surveys of married or in-union women of reproductive age were conducted to determine baseline measures of family planning knowledge, attitudes and behaviors regarding contraception. Health facility assessments were carried out to assess baseline measures of family planning services availability. Data were double-entered into CSPro 3.2 and exported to SAS 9.2, which was used to calculate descriptive statistics. The studies' purposes were to guide program activities and to serve as a baseline against which program accomplishments could be measured. Results: Knowledge of modern contraceptive methods was low relative to other sub-Saharan African countries, and use of modern methods was under 4% in four sites; in two sites with prior family planning services it was 12% and 16.2%. From 30% to 40% of women reported they did not want a child within two years, however, and an additional 12% to 35% wanted no additional children, suggesting a clear need for family planning services. The health facilities assessment showed that at most only one-third of the facilities mandated to provide family planning had the necessary staff, equipment and supplies to do so adequately; in some areas, none of the facilities were prepared to offer such services. Conclusions: Family planning services are desired by women living in crisis situations when offered in a manner appropriate to their needs, yet services are rarely adequate to meet these needs. Refugee and internally displaced women must be included in national and donors' plans to improve family planning in Africa.
Additional file 1 of Barriers and facilitators of clinician and researcher collaborations: a qualitative study
Creators: name: Williams, Julie
name: Craig, Tom J.
name: Robson, Debbie
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: Additional file 1.
MicroRNA expression in HTLV-1 infection and pathogenesis
Creators: name: De Bellis, Gianluca
name: Corti, Giorgio
name: Zanovello, Paola
name: Bronte, Vincenzo
name: Guffanti, Alessandro
name: Basso, Katia
name: Corradin, Alberto
name: Pise-Masison, Cynthia A.
name: Bortoluzzi, Stefania
name: Biasiolo, Marta
name: Ruggero, Katia
name: D’Agostino, Donna M.
name: Ciminale, Vincenzo
Publisher: name: Columbia University
Year: 2011
Subjects: DNA microarrays--Data processing
Retroviruses
HTLV-I infections
Virology
Molecular biology

description: Our laboratory is examining the profiles of microRNA expression in ATLL cells and infected T-cell lines using microarrays and small RNA libraries.

Microarray analysis of ATLL samples revealed 6 upregulated and 21 downregulated microRNAs in ATLL cells compared to CD4+ T-cell controls. Potential targets for deregulated microRNAs were identified by integrating microRNA and mRNA expression profiles. Current experiments are aimed at verifying these predicted microRNA-target interactions.
Specific features of electron spin resonance in quasi-1D magnet β-TeVO4
Creators: name: Savina, Yu.
name: Bludov, A.
name: Pashchenko, V.
name: Gnatchenko, S.
name: Stepanov, A.
name: Lemmens, P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The angular and temperature dependences of single crystal ESR spectra at X-band frequency of quasi 1D spin 1/2 antiferromagnetic zigzag chain system β-TeVO4 are reported. Two resonance components in the ESR spectrum have been detected: a weak narrow resonance on the top of the extremely broad signal. The narrow line might be due to an impurity, the characteristics of the broad absorption do not correlate with a picture of the typical behavior for the V4+ ions (S = 1/2) with a square pyramidal environment. It was found that at low temperatures the divergence of the spin susceptibility and linewidth of the observed excitations can be due to a realization of three dimensional magnetic ordering.
description: 9 pages, 6 figures, 1 table
Bassaricyon pauli Enders 1936
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Procyonidae
Bassaricyon
Bassaricyon pauli

description: Bassaricyon pauli Enders, 1936. Proc. Acad. Nat. Sci. Phila., 88:365. TYPE LOCALITY: Panama, Chiriqui, Cerro Pando, between Rio Chiriqui Viejo and Rio Colorado (about 10 mi. (16 km) from El Volcan.) DISTRIBUTION: Known only from the type locality.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Carnivora, pp. 244-289 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 253, DOI: 10.5281/zenodo.7352980
Ghost-Free Massive $f(R)$ Theories Modelled as Effective Einstein Spaces and Cosmic Acceleration
Creators: name: Vacaru, Sergiu I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Physics (physics.gen-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study how massive ghost-free gravity $f(R)$-modified theories, MGFTs, can be encoded into generic off-diagonal Einstein spaces. Using "auxiliary" connections completely defined by the metric fields and adapted to nonholonomic frames with associated nonlinear connection structure, we decouple and integrate in certain general forms the field equations in MGFT. Imposing additional nonholonomic constraints, we can generate Levi-Civita, LC, configurations and mimic MGFT effects via off-diagonal interactions of effective Einstein and/or Einstein-Cartan gravity with nonholonomically induced torsion. We show that imposing nonholonomic constraints it is possible reproduce very specific models of massive $f(R)$ gravity studied in \cite{sarid,odintsr}. The cosmological evolution of ghost-free off-diagonal Einstein spaces is investigated. Certain compatibility of MGFT cosmology to small off--diagonal deformations of $Λ$CDM models is established.
description: latex2e, 9 pages, version accepted to EJPC in a form modified following referee's requests
Radboud Data Repository - Getting Started
Creators: name: De Laat, Stijn
name: Jansen, Daphne
name: Lamers, Didi
name: Marcoux, Katherine
name: Slouwerhof, Inge
name: van der Burgt, Henry
Publisher: name: Zenodo
Year: 2024
Subjects: Radboud Data Repository
RDR
research data management
RDM
research data
data management

description: The presentation of the introductory course for first time users of the Radboud Data Repository (RDR). The original presentation introduces researchers to the basic functionalities of the Radboud Data Repository and shows how to get started in a short demonstration. In this registration, only the presentation is included and not the demonstration.

The presentation discusses the collections types available in the RDR, the roles that can be assigned to people involved in your collection and the different access levels available for your collection when publishing your data. Furthermore, it will include information on how the RDR fits within the Research Data Management landscape, how to best use the RDR in your daily research and some best practices and tips for the practical use of the RDR.
Radboud Data Repository - Getting Started
Creators: name: De Laat, Stijn
name: Jansen, Daphne
name: Lamers, Didi
name: Marcoux, Katherine
name: Slouwerhof, Inge
name: van der Burgt, Henry
Publisher: name: Zenodo
Year: 2024
Subjects: Radboud Data Repository
RDR
research data management
RDM
research data
data management

description: The presentation of the introductory course for first time users of the Radboud Data Repository (RDR). The original presentation introduces researchers to the basic functionalities of the Radboud Data Repository and shows how to get started in an interactive demonstration. In this registration, only the presentation is included and only some discussion slides of the demonstration.

The presentation discusses the collections types available in the RDR, the roles that can be assigned to people involved in your collection and the different access levels available for your collection when publishing your data. It mainly focusses on the practical use of beginning RDR users.
Additional file 1 of Cardiac MRI-based right-to-left ventricular blood pool T2 relaxation times ratio correlates with exercise capacity in patients with chronic heart failure
Creators: name: Halfmann, Moritz C.
name: Müller, Lukas
name: von Henning, Urs
name: Kloeckner, Roman
name: Schöler, Theresia
name: Kreitner, Karl-Friedrich
name: Düber, Christoph
name: Wenzel, Philip
name: Varga-Szemes, Akos
name: Göbel, Sebastian
name: Emrich, Tilman
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1: Table S1. Comparison of CMR parameters between patient groups. Table S2. Results from post-hoc tests between types of HF and HC. Table S3. Multivariate regression analyses for distance walked in 6MWT. Table S4. Univariate regression analyses for distance walked in 6MWT.
Radboud Data Repository - Getting Started
Creators: name: De Laat, Stijn
name: Jansen, Daphne
name: Lamers, Didi
name: Marcoux, Katherine
name: Slouwerhof, Inge
name: van der Burgt, Henry
Publisher: name: Zenodo
Year: 2025
Subjects: Radboud Data Repository
RDR
research data management
RDM
research data
data management

description: The presentation of the introductory course for first time users of the Radboud Data Repository (RDR). The original presentation introduces researchers to the basic functionalities of the Radboud Data Repository and shows how to get started in an interactive demonstration. In this registration, only the presentation is included and only some discussion slides of the demonstration.

The presentation discusses the collections types available in the RDR, the roles that can be assigned to people involved in your collection and the different access levels available for your collection when publishing your data. It mainly focusses on the practical use of beginning RDR users.
УМЕНЕЕ ВЛИЯТЬ И  ПРОГРЕССИРОВАТЬ  КАК ЛИЧНОСТЬ В РОСТЕ И САМОРАЗВИТИИ.
Creators: name: Махаматкулов, Зуфар
Publisher: name: Zenodo
Year: 2023

description: Когда мы говорим о саморазвитии, следует также сказать, что к нему относится наставничество. Если мы усвоили педагогические приемы, мастерство  и умеем влиять на учеников этим  образом, что они прогрессируют как личности, значит мы и сами растем.Помимо улучшения  себя, саморазвитие проявляется при помощи практики и исследований.
Radboud Data Repository - Getting Started
Creators: name: De Laat, Stijn
name: Jansen, Daphne
name: Lamers, Didi
name: Marcoux, Katherine
name: Slouwerhof, Inge
name: van der Burgt, Henry
Publisher: name: Zenodo
Year: 2023
Subjects: Radboud Data Repository
RDR
research data management
RDM
research data
data management

description: The presentation of the introductory course for first time users of the Radboud Data Repository (RDR). The original presentation introduces researchers to the basic functionalities of the Radboud Data Repository and shows how to get started in a short demonstration. In this registration, only the presentation is included and not the demonstration. The presentation discusses the collections types available in the RDR, the roles that can be assigned to people involved in your collection and the different access levels available for your collection when publishing your data. Furthermore, it will include information on how the RDR fits within the Research Data Management landscape, how to best use the RDR in your daily research and some best practices and tips for the practical use of the RDR.
The Near Field Refractor
Creators: name: Gutierrez, Cristian E.
name: Huang, Qingbo
Publisher: name: arXiv
Year: 2013
Subjects: subject: Analysis of PDEs (math.AP)
subject: Optics (physics.optics)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 78A05, 35Q60, 52B12, 47H04

description: We present an abstract method in the setting of compact metric spaces which is applied to solve a number of problems in geometric optics. In particular, we solve the one source near field refraction problem. That is, we construct surfaces separating two homogenous media with different refractive indices that refract radiation emanating from the origin into a target domain contained in an n-1 dimensional hypersurface. The input and output energy are prescribed. This implies the existence of lenses focusing radiation in a prescribed manner.
description: 39 pages, 4 figures, Annales de l'Institut Henri Poincare (C) Analyse Non Lineaire (to appear). Geometric optics, lens design, measure equations, Descartes ovals, Monge-Ampere type equations
Additional file 1 of The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis
Creators: name: Matthews, Joseph J.
name: Dolan, Eimear
name: Swinton, Paul A.
name: Santos, Livia
name: Artioli, Guilherme G.
name: Turner, Mark D.
name: Elliott-Sale, Kirsty J.
name: Sale, Craig
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Supporting information.
Modifications in the frustrated magnetism, oxidation state of Co and magnetoelectric coupling effects induced by a partial replacement of Ca by Gd in the spin chain compound Ca3Co2O6
Creators: name: Basu, Tathamay
name: Singh, Kiran
name: Sampathkumaran, E. V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have systematically investigated the influence of gradual replacement of Ca by Gd on the magnetic and complex dielectric properties of the well-known geometrically frustrated spin-chain system, Ca3Co2O6 (T_N= 24 K with additional magnetic transitions below 12K), by studying the series, Ca3-xGdxCo2O6 (x less than 0.7), down to 1.8K. Heat capacity measurements establish that the reduction of T_N with Gd substitution is much less as compared to that by Y substitution. The magnetic moment data reveal that there are changes in the oxidation state of Co as well, unlike for Y-substitution, beyond x= 0.2. Thus, despite being isovalent, both these substitutions interestingly differ in changing these magnetic properties in these oxides. We propose that the valence electrons of Y and those of R ions play different roles on deciding these magnetic characteristics of these mixed oxides. It is observed that a small amount (x= 0.3) of Gd substitution for Ca is enough to suppress glassy ac magnetic susceptibility behavior for the peak around 12 K. An additional low-temperature magnetic anomaly close to 5 K gets more prominent with increasing Gd concentration as revealed by heat-capacity data. Trends in temperature dependence of complex dielectric behavior were also tracked with varying composition and a frequency dependence is observed, not only for the transition in the region around 10 K (for some compositions), but also for the 5 K transition which is well-resolved for a higher concentration of Gd. Thus, Gd-substituted Ca3Co2O6 series is shown to reveal interesting magnetic and dielectric behavior of this family of oxides.
description: JPCM, in press
Additional file 1 of Spectral, thermal, antimicrobial studies for silver(I) complexes of pyrazolone derivatives
Creators: name: Mohamed, Soha F.
name: Shehab, Wesam S.
name: Aboubakr M. Abdullah
name: Sliem, Mostafa H.
name: El-Shwiniy, Walaa H.
Publisher: name: figshare
Year: 2020
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1: Table S1. UV-Vis. spectral data of the free ligand L1, L2, L3 and their Ag(I)-complexes. Table S2. Selected 1H NMR data of L1, L2, L3 and its diamagnetic complexes. Fig. S1. TGA and DTG diagrams for a L1, b [Ag(L1)2(H2O)2]NO3, c, L2 d [Ag(L2)2(H2O)2]NO3.H2O, e L3 and f [Ag(L3)2(H2O)2]NO3. Fig. S2. The diagrams of kinetic parameters of L1, [Ag(L1)2(H2O)2]NO3, L2, [Ag(L2)2(H2O)2]NO3.H2O, L3 and [Ag(L3)2(H2O)2]NO3using Coats-Redfern (CR) and Horowitz-Metzger (HM) equations. Scheme S1. Fragmentation pattern of [Ag(L1)2(H2O)2]NO3. Scheme S2. Fragmentation pattern of [Ag(L2)2(H2O)2]NO3.H2O. Scheme S3. Fragmentation pattern of [Ag(L3)2(H2O)2]NO3
Lemma 4: Haptic Input + Auditory Display = Musical Instrument?
Creators: name: Vickers, Paul
Publisher: name: arXiv
Year: 2013
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: In this paper we look at some of the design issues that affect the success of multimodal displays that combine acoustic and haptic modalities. First, issues affecting successful sonification design are explored and suggestions are made about how the language of electroacoustic music can assist. Next, haptic interaction is introduced in the light of this discussion, particularly focusing on the roles of gesture and mimesis. Finally, some observations are made regarding some of the issues that arise when the haptic and acoustic modalities are combined in the interface. This paper looks at examples of where auditory and haptic interaction have been successfully combined beyond the strict confines of the human-computer application interface (musical instruments in particular) and discusses lessons that may be drawn from these domains and applied to the world of multimodal human-computer interaction. The argument is made that combined haptic-auditory interaction schemes can be thought of as musical instruments and some of the possible ramifications of this are raised.
description: in Haptic and Audio Interaction Design: First International Workshop, HAID 2006, Glasgow, UK, August 31 - September 1, 2006. Proceedings (D. McGookin and S. Brewster, eds.), vol. 4129/2006 of Lecture Notes in Computer Science, pp. 56-67, Springer-Verlag, 2006
Partitions of large unbalanced bipartites
Creators: name: Bureaux, Julien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: We compute the asymptotic behaviour of the number of partitions of large vectors $(n_1,n_2)$ of $\mathbb{Z}_+^2$ in the critical regime $n_1 \asymp \sqrt{n_2}$ and in the subcritical regime $n_1 = o(\sqrt{n_2})$. This work completes the results established in the fifties by Auluck, Nanda, and Wright.
ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study
Creators: name: Dorado, Pedro
name: Lopez-Castroman, Jorge
name: Almoguera, Berta
name: Riveiro-Alvarez, Rosa
name: Lopez-Rodriguez, Rosario
name: Fernandez-Navarro, Pablo
name: Baca-Garcia, Enrique
name: Fernandez-Piqueras, Jose
name: Dal-Ré, Rafael
name: Abad-Santos, Francisco
name: LLerena, Adrián
name: Ayuso, Carmen
Publisher: name: Columbia University
Year: 2011
Subjects: subject: Schizophrenia--Genetic aspects
subject: Hispanic Americans
subject: Schizophrenia--Etiology
subject: Schizophrenia--Risk factors
subject: Genetics
subject: FOS: Biological sciences
subject: Psychobiology
subject: Mental health

description: Background: Three IL-10 gene promoter single nucleotide polymorphisms -1082G > A, -819C > T and -592C > A and the haplotypes they define in Caucasians, GCC, ACC, ATA, associated with different IL-10 production rates, have been linked to schizophrenia in some populations with conflicting results. On the basis of the evidence of the sex-dependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population. Methods: 241 DSM-IV diagnosed Spanish schizophrenic patients and 435 ethnically matched controls were genotyped for -1082G > A and -592C > A SNPs. Chi squared tests were performed to assess for genetic association of alleles, genotypes and haplotypes with the disease. Results: The -1082A allele (p = 0.027), A/A (p = 0.008) and ATA/ATA (p = 0.003) genotypes were significantly associated with schizophrenia in females while neither allelic nor genotypic frequencies reached statistical significance in the male population. Conclusions: Our results highlight the hypothesis of an imbalance towards an inflammatory syndrome as the immune abnormality of schizophrenia. Anyway, a better understanding of the involvement of the immune system would imply the search of immune abnormalities in endophenotypes in whose sex and ethnicity might be differential factors. It also reinforces the need of performing complex gene studies based on multiple cytokine SNPs, including anti and pro-inflammatory, to clarify the immune system abnormalities direction in the etiology of schizophrenia.