cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Taxing choices: international competition, domestic institutions and the transformation of corporate tax policy
Creators: name: Swank, Duane
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Since the 1980s, notable corporate tax base broadening and rate reductions have occurred throughout the rich democracies. Scholars agree that tax competition for mobile assets shapes this transformation. I address two questions in this article. First, what form has tax competition taken and, second, how have domestic institutions conditioned competition's impact? I build on past work and argue that tax competition is characterized by the (Stackelberg) leadership of the United States as opposed to alternative forms of competition. At the same time, domestic institutions, especially the degree to which the nation is a co-ordinated versus liberal market economy, are central determinants of the pace of reform. I test these propositions with models of 1982–2008 tax rate change in 18 capitalist democracies. I find that rising trade openness and capital mobility place downward pressures on tax rates, the United States' adoption of the neoliberal tax model engenders significant competitive responses from other nations, and that the institutions of co-ordinated economies slow the pace of neoliberal reforms. High public debt, left-leaning median voters and institutional veto points also significantly constrain tax policy change. I conclude with some reflections on tax policy in the wake of the global financial crisis and on neoliberalism and institutional change in advanced democratic capitalism.
Crimes against urbanity: The concrete soul of michael mann
Creators: name: Lobato, Ramon
Publisher: name: Swinburne
Year: 2024

description: The relationship between crime narratives and generic urban space is the central concern of this article, which will attempt to pose some tentative answers to a set of mysteries that lie at the heart of the contemporary crime movie---what are the aesthetics of detection? How do criminal fictions negotiate the postmodern city? Why do hotels, airports and railway stations make such evocative crime scenes? And what can the genre teach us about the way we engage with our own urban spaces? The films of Michael Mann are, I will suggest, exemplary of a tendency which is present, if unevenly distributed, across a large number of criminal fictions. The crime genre, particularly in its police-procedural and heist-movie variations, is in this sense a lens through which we can examine the mutually constitutive relationship between city-image and self-image. It aestheticizes the infrastructure of late capitalism through a dialectic of enchantment and defacement, providing a vantage point from which generic urban space can be reimagined as a site of fantasy. I focus here on a selection of Mann's crime films which, like all his work, exhibit a pronounced tendency towards spatial abstraction. My intention here is not to offer an appreciation of Mann's work so much as to make a case for the crime genre's capacity to function as a staging ground for spatial politics, a capacity which has implications for the way we visualize city space at the level of the everyday.
Molecular dynamics investigations of BioH protein substrate specificity for biotin synthesis
Creators: name: Xue, Qiao
name: Ying-Lu Cui
name: Zheng, Qing-Chuan
name: Zhang, Hong-Xing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: BioH, an enzyme of biotin synthesis, plays an important role in fatty acid synthesis which assembles the pimelate moiety. Pimeloyl-acyl carrier protein (ACP) methyl ester, which is long known to be a biotin precursor, is the physiological substrate of BioH. Azelayl methyl ester, which has a longer chain than pimeloyl methyl ester, conjugated to ACP is also indeed accepted by BioH with very low rate of hydrolysis. To date, the substrate specificity for BioH and the molecular origin for the experimentally observed rate changes of hydrolysis by the chain elongation have remained elusive. To this end, we have investigated chain elongation effects on the structures by using the fully atomistic molecular dynamics simulations combined with binding free energy calculations. The results indicate that the substrate specificity is determined by BioH together with ACP. The added two methylenes would increase the structural flexibility by protein motions at the interface of ACP and BioH, instead of making steric clashes with the side chains of the BioH hydrophobic cavity. On the other hand, the slower hydrolysis of azelayl substrate is suggested to be associated with the loose of contacts between BioH and ACP, and with the lost electrostatic interactions of two ionic/hydrogen bonding networks at the interface of the two proteins. The present study provides important insights into the structure–function relationships of the complex of BioH with pimeloyl-ACP methyl ester, which could contribute to further understanding about the mechanism of the biotin synthetic pathway, including the catalytic role of BioH.
Distinct processing of objects and faces in the infant brain
Creators: name: Southgate, Victoria
name: Csibra, Gergely
name: Kaufman, Jordy
name: Johnson, Mark H.
Publisher: name: Swinburne
Year: 2024

description: Previous work has shown that gamma-band electroencephalogram oscillations recorded over the posterior cortex of infants play a role in maintaining object representations during occlusion. Although it is not yet known what kind of representations are reflected in these oscillations, behavioral data suggest that young infants maintain spatiotemporal (but not featural) information during the occlusion of graspable objects, and surface feature (but not spatiotemporal) information during the occlusion of faces. To further explore this question, we presented infants with an occlusion paradigm in which they would, on half of the trials, see surface feature violations of either a face or an object. Based on previous studies, we predicted higher gamma-band activation when infants were presented with a surface feature violation of a face, but not of an object. These results were confirmed. A further analysis revealed that whereas infants exhibited a significant increase in gamma during the occlusion of an object (as reported in previous studies), no such increase was evident during the occlusion of a face. These data suggest markedly different processing of objects and faces in the infant brain and, furthermore, indicate that the representation under-pinned by the posterior gamma increase may contain only spatiotemporal information.
Speculative naturalism: A manifesto
Creators: name: Gare, Arran
Publisher: name: Swinburne
Year: 2024

description: The turn to analytic philosophy, which is still underway, has generally involved a retreat from ‘synoptic' thinking and an almost complete withdrawal from ‘synthetic' thinking, the creative thinking that in the past has been the source of the greatest contributions of philosophy to science, the humanities and civilization. Analytic philosophy's ‘naturalistic turn' led by Willard van Ormond Quine was really a capitulation of philosophy to mainstream reductionist science. So-called ‘continental philosophy', by abjuring naturalism, offers no real challenge to this. This paper attempts to recover a much more powerful challenge to such analytic philosophy and reductionist science, a philosophy which is naturalist but values synopsis and synthesis along with analysis: speculative naturalism. As such, this is presented as a manifesto not only for philosophy, but for science and the humanities. As Mikhail Epstein argued, the practical outcome of the humanities is the transformation of culture. To transform culture is to transform ourselves, our society and our relationship to each other and to nature.
Reassessment of Melittis melissophyllum L. subsp. melissophyllum iridoidic fraction
Creators: name: A. Venditti
name: A. Bianco
name: M. Serafini
name: C. Frezza
name: L. Guarcini
name: F. Maggi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences

description: The analysis of the polar fraction of Melittis melissophyllum L. subsp. melissophyllum led to the identification of several iridoid glycosides: monomelittoside (1), melittoside (2), harpagide (3), acetyl-harpagide (4) and ajugoside (5). Compounds 3 and 4 are considered marker compounds for the genus and, as well as compounds 1, 2 and 5, were already evidenced in a previous study on the nominal species. It was noteworthy of the presence of allobetonicoside (6) which was never reported for this genus. The isolation of 6 is very relevant because of its allose residue on the structure. Allose has been often found in the species of the subfamily Lamioideae even if it mostly regarded flavonoids considered of chemotaxonomical relevance for some correlated genera of Lamiaceae. Same as allosyl-glycosidic flavonoids, the presence of allosyl-glycosidic iridoids may also be an additional chemosystematic evidence of botanical relationships among Lamiaceae species and genera.
Implementation of project-oriented design-based learning in a second-year mechanical/mechatronics subject
Creators: name: Long, John M.
name: Pereira, Michael
name: Chandrasekaran, Sivachandran
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 3901
subject: Curriculum and pedagogy
classificationCode: 390303
subject: Higher education
classificationCode: 401003
subject: Engineering practice

description: CONTEXT The School of Engineering at Deakin University has undergone a significant transition towards making design and projects the basis for the undergraduate curriculum rather than the more traditional approach based on lectures, texts, and examinations. A new curriculum, called Project-Oriented Design-Based Learning (PODBL), is now in its second year of implementation. The curriculum allows for approximately one half of the total content in the course to be based on design projects. PURPOSE This study seeks to study and evaluate the effectiveness of a second-year mechanical unit in the new PODBL curriculum. APPROACH SEM200, Machine Design, was developed as a new two-credit-point unit in the Bachelor of Engineering, mechanical and mechatronics streams. It runs in the first semester of the second year, and is takes up one half of the total content in the semester (two credit points). The remaining half of semester is shared between a unit on engineering mathematics and another on fluid mechanics (one credit point each). The main project for this unit is centred on the design of a mechanical-based machine that must perform a defined set of tasks with a defined set of criteria. The project aims to reflect a real-world engineering project environment. Students work in teams. The assessment consists of a team project plan, a team presentation of the final product, an interim report, and a final portfolio. The unit is offered both to on-campus students at Geelong and online. RESULTS The unit been offered twice – in 2016 and again in 2017. The project for both years was to build a robot following the rules and specifications of the Engineers-Australia Warman Design-and-Build Competition. Forty-eight students completed the unit in 2016, and 100 students completed the unit in 2017. The average mark for 2016 was 66/100, and for 2017, the average mark was 67/100. Student reviews of the unit were mostly positive and the teaching team have learned a number of important lessons that will influence further offerings of this and other PODBL units. CONCLUSIONS SEM200 is the third two-credit-point project-design unit in which mechanical and mechatronics students enrol. The academic performance of the students indicates that the content and assessment is appropriate for second-year students. The student feedback suggests that although the unit involves a great deal of work, students enjoyed both the challenge posed by the unit and the satisfaction of completing a complicated design project in the space of a single semester.
TIJORAT SIRI TO'G'RISIDAGI QONUNCHILIKNI BUZGANLIK UCHUN JAVOBGARLIK MASALALARI
Creators: name: Raxmonaliyeva, Mukambar
Publisher: name: Zenodo
Year: 2024

description: Ushbu tezisda tijorat siri to‘g‘risidagi qonunchilikni buzganlik uchun qo‘llaniladigan javobgarlik turlari va ularning bir-biridan farqli jihatlari olimlar fikri, amaliyotdagi holatlar asosida yoritib beriladi.
Functionalized Phosphonium Ionic Liquids: Synthesis and Application
Creators: name: Arkhipova, Daria
name: Ermolaev, Vadim
name: Miluykov, Vasili
name: Nigmatullina, Lilia
name: Sinyashin, Oleg
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology

description: GRAPHICAL ABSTRACT
Automatic Classification of Musical Instrument Samples
Creators: name: Scarano, Daniele
Publisher: name: Zenodo
Year: 2016

description: Automatic classification of musical instrument is an old research topic in music information retrieval. In this work we address the problem of the classification using musical instrument single note samples from Freesound and we put the accent on the content analysis of the sound and how those content information are connected to the physical characteristics of each instrument. We build a taxonomy based on instrument families and mode of excitation. The musical instruments play a central role in this work and the studies on timbre are used as a methodological base to apply feature selection to our complete set of descriptors, the aim of this is to find which descriptors are relevant to describe a specific instrument. The machine learning then is used as an instrument to evaluate our choices, to identify weakness and problem in the current implementation of audio descriptors.
Molecular dynamics investigations of BioH protein substrate specificity for biotin synthesis
Creators: name: Xue, Qiao
name: Ying-Lu Cui
name: Zheng, Qing-Chuan
name: Zhang, Hong-Xing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: :BioH, an enzyme of biotin synthesis, plays an important role in fatty acid synthesis which assemble the pimelate moiety. Pimeloyl-acyl carrier protein (ACP) methyl ester, which is long known to be a biotin precursor, is the physiological substrate of BioH. Azelayl methyl ester, which has a longer chain than pimeloyl methyl ester, conjugated to ACP is also indeed accepted by BioH with very low rate of hydrolysis. To date, the substrate specificity for BioH and the molecular origin for the experimentally observed rate changes of hydrolysis by the chain elongation have remained elusive. To this end, we have investigated chain elongation effects on the structures by using the fully atomistic molecular dynamics simulations combined with binding free energy calculations. The results indicate that the substrate specificity is determined by BioH together with ACP. The added two methylenes would increase the structural flexibility by protein motions at the interface of ACP and BioH, instead of making steric clashes with the side chains of the BioH hydrophobic cavity. On the other hand, the slower hydrolysis of azelayl substrate is suggested to be associated with the loose of contacts between BioH and ACP, and with the lost electrostatic interactions of two ionic/hydrogen bonding networks at the interface of the two proteins. The present study provides important insights into the structure-function relationships of the complex of BioH with pimeloyl-ACP methyl ester, which could contribute to further understanding about the mechanism of the biotin synthetic pathway, including the catalytic role of BioH.
Analytical model of graphene-based biosensors for bacteria detection
Creators: name: Elnaz Akbari
name: Zolkafle Buntat
name: Kiani, Mohammad J.
name: Enzevaee, Aria
name: Khaledian, Mohsen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology
subject: FOS: Biological sciences

description: In this research, a set of novel models based on field effect transistor (FET) structure using graphene have been proposed with the current–voltage (I–V) characteristics of graphene employed to model the sensing mechanism. It has been observed that the graphene device experiences a drastic increase in conductance when exposed to Escherichia coli bacteria at 0– cfu/mL concentrations. Hence, simplicity of the structure, fast response rate and high sensitivity of this nanoelectronic biosensor make it a more suitable device in screening and functional studies of antibacterial drugs and an ideal high-throughput platform that can detect any pathogenic bacteria. Accordingly, the proposed model exhibits a satisfactory agreement with the experimental data.
Quality and yield of snap bean lines locally developed in Kenya
Creators: name: Iqbal, Zahid
Publisher: name: figshare
Year: 2015
Subjects: subject: Environmental Science
subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: Soil Science
subject: Genetics
subject: FOS: Biological sciences
subject: Education

description: Snap bean varieties with high yields of extra fine and fine yield are preferred to avoid heavy postharvest losses and
reduced consumer appeal. The objective of this study was to select snap bean populations and lines developed for
multiple disease resistance for high pod quality and yield. Six groups of snap beans populations at different
generations and 49 snap bean lines including local checks were evaluated for their yield performance at KARIThika
and Mwea for two seasons. Data collected included duration to flowering and maturity, pod length and
width, number of pods per plant, marketable pod yield and pod quality (extra fine, fine and bobby). There were
significant differences among the genotypes with respect to days to flowering, days to maturity, pod length, pod
diameter, marketable pod yield and pod quality. Climbing snap bean took the longest duration to flower and
mature compared to bush snap beans. Snap bean populations and lines with higher number of pods per plant, pod
length and pod diameter than the local checks were recorded. Climbing lines had a highest pod diameter of 11mm
among the snap bean lines. HAB 423 had the highest pod yield of 15.1 t/ha while Star 2053 was the best yielding
parent check with pod yield of 11.5 t/ha. Star 2053 had the highest proportion of extra fine pod yield (92.6%) while
SB-08-3-2 population had the highest proportion (85.8%) among the populations and lines. Therefore, it is evident
that locally develop snap bean varieties with multiple disease resistance and high yields of acceptable quality can
be achieved.
Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome.
Creators: name: Li, Cai
name: Luscombe, Nicholas M
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Genetics & Genomics
Gene Expression
Tumour Biology
Computational & Systems Biology

description: Nucleosome organization has been suggested to affect local mutation rates in the genome. However, the lack of de novo mutation and high-resolution nucleosome data has limited the investigation of this hypothesis. Additionally, analyses using indirect mutation rate measurements have yielded contradictory and potentially confounding results. Here, we combine data on >300,000 human de novo mutations with high-resolution nucleosome maps and find substantially elevated mutation rates around translationally stable ('strong') nucleosomes. We show that the mutational mechanisms affected by strong nucleosomes are low-fidelity replication, insufficient mismatch repair and increased double-strand breaks. Strong nucleosomes preferentially locate within young SINE/LINE transposons, suggesting that when subject to increased mutation rates, transposons are then more rapidly inactivated. Depletion of strong nucleosomes in older transposons suggests frequent positioning changes during evolution. The findings have important implications for human genetics and genome evolution.
Elementos para sistematização conceitual: um estudo sobre a relação do varejo e a marca própria no mercado brasileiro
Creators: name: Teixeira, Alex Volnei
name: Laurindo, Alisson
name: Keli Pereira
Publisher: name: figshare
Year: 2015
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: Theoretical Computer Science

description: The purpose of this research is to gather elements that can contribute to a systematic conceptual and a better understanding of the relationship between retail and private label as well as start a discussion about trends and their influence on consumer buying behavior at the point of sale networks retail in Brazil. Through a qualitative research methodology identified the need for further study on possible impacts on Brand equity of national brands because the brands are investing in quality seeking to consolidate their place in the national market.
Rewilding Harvard: Old Harvard Yard GIS Photo Project
Creators: name: Lipton, Belle
Publisher: name: OSF
Year: 2024

description: GIS dataset from Old Harvard Yard project from Spring 2024 history course, Rewilding Harvard, by students by Emily Arbuiso, Avery Britt, Mia DiLorenzo, Nikita Nair, Hayden Teeter, Cody Vasquez, and Alyssia Wiesenbauer.
Contact activatie en arteriele trombose
Creators: name: Siegerink, Bob
Publisher: name: figshare
Year: 2015
Subjects: Medicine

description: B ack g r o
und :
Classically, intrinsic coagulation proteins are assumed to have a minor role
in haemostasis. Recently these proteins were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred by increased activation of intrinsic coagulation proteins in young women and the effect of the use of oral contraceptives on this association.
M eth o d s a n d Re s ult s : The Risk of Arterial Thrombosis In relation to Oral contraceptives-study
is a population-based case-control study including young women (age 18-50 years) with myocardial infarction (n=205) and ischemic stroke (n=175) and 638 healthy controls. Intrinsic coagulation protein activation was determined by measuring activated protein-inhibitor complexes. The proteins are in complex with either C1 esterase inhibitor (FXIIa-C1-INH, FXIa-C1-INH, Kallikrein-C1-INH) or antitrypsin inhibitor (FXIa-AT-INH). Odds ratios (OR’s) and corresponding confidence intervals (95% CI’s) were calculated with logistic regression. High levels of protein activation (>90th percentile of controls) showed an increased risk of ischemic stroke: FXIIa-C1-INH (OR, 2.1; 95% CI, 1.3-3.5), FXIa-C1-INH (OR, 2.8; 95% CI, 1.6-4.7), FXIa-AT-INH (OR, 2.3; 95% CI, 1.4-4.0), and kallikrein-C1 (OR, 4.3; 95% CI, 2.6-7.2). If anything, myocardial infarction risk was only increased by kallikrein-C1-INH (OR, 1.5; 95% CI, 0.9-2.5). The use of oral contraceptives further increased the risks.
C on c l u s i
associated with arterial thrombosis, whereas the strength of these associations differs for
ons :High levels of activated proteins of the intrinsic coagulation system are
myocardial infarction and ischemic stroke. Although the use of oral contraceptives incre- ase this risk, it appears that screening for intrinsic coagulation activation before OC use is not warranted
title: Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes
Creators: name: Hartung, Niklas
name: Benary, Uwe
name: Wolf, Jana
name: Kofahl, Bente
Publisher: name: Universität Potsdam
Year: 2020

description: Background Cells are able to communicate and coordinate their function within tissues via secreted factors. Aberrant secretion by cancer cells can modulate this intercellular communication, in particular in highly organised tissues such as the liver. Hepatocytes, the major cell type of the liver, secrete Dickkopf (Dkk), which inhibits Wnt/ β-catenin signalling in an autocrine and paracrine manner. Consequently, Dkk modulates the expression of Wnt/ β-catenin target genes. We present a mathematical model that describes the autocrine and paracrine regulation of hepatic gene expression by Dkk under wild-type conditions as well as in the presence of mutant cells. Results Our spatial model describes the competition of Dkk and Wnt at receptor level, intra-cellular Wnt/ β-catenin signalling, and the regulation of target gene expression for 21 individual hepatocytes. Autocrine and paracrine regulation is mediated through a feedback mechanism via Dkk and Dkk diffusion along the porto-central axis. Along this axis an APC concentration gradient is modelled as experimentally detected in liver. Simulations of mutant cells demonstrate that already a single mutant cell increases overall Dkk concentration. The influence of the mutant cell on gene expression of surrounding wild-type hepatocytes is limited in magnitude and restricted to hepatocytes in close proximity. To explore the underlying molecular mechanisms, we perform a comprehensive analysis of the model parameters such as diffusion coefficient, mutation strength and feedback strength. Conclusions Our simulations show that Dkk concentration is elevated in the presence of a mutant cell. However, the impact of these elevated Dkk levels on wild-type hepatocytes is confined in space and magnitude. The combination of inter- and intracellular processes, such as Dkk feedback, diffusion and Wnt/ β-catenin signal transduction, allow wild-type hepatocytes to largely maintain their gene expression.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 886
Microbial Distribution in a Hydrothermal Plume of the Southwest Indian Ridge
Creators: name: Jiangtao Li
name: Huaiyang Zhou
name: Jiasong Fang
name: Zijun Wu
name: Xiaotong Peng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Hydrothermal plumes are widely distributed throughout the global spreading ridges, yet few of them are microbiologically explored. The ultraslow-spreading ridges, recently recognized as a unique, new class of mid-ocean-ridge system, have provided surprises and new insights in hydrothermal system research. A suite of water column samples including both hydrothermal plume samples and ambient seawater were collected at different depths from the ultraslow-spreading Southwest Indian Ridge (SWIR) in 2010. We use molecular approaches such as clone libraries, denaturing gradient gel electrophoresis (DGGE) and quantitative PCR to determine microbial community compositions and their spatial variability within the hydrothermal plume and seawater. Phylogenetic analysis showed that plume samples were mainly dominated by members of α-Proteobacteria and γ-Proteobacteria and members of marine group I group within the Crenarchaeota. Within the hydrothermal plume, archaeal populations were spatially homogeneous, while bacterial compositions were heterogeneous and remarkably distinct at different depths. Moreover, several lineages, closely related to known Mn(II) oxidizers were found to be abundant and even predominant within the plume bacterial communities. DGGE band patterns showed that there was no significant difference in microbial compositions between the samples of hydrothermal plume and ambient seawater. Taken together, we inferred that microbial communities in the SWIR hydrothermal plumes were sourced from ambient seawater rather than from seafloor vent-derived niches. This is the first report on the characteristics of microbial community structures in hydrothermal plume and ambient seawater in the Southwest Indian Ridge.
Developing Papua New Guinea’s Tourism Sector
Creators: name: Sumb, Allan
Publisher: name: Canberra, ACT: Dept. of Pacific Affairs, Research School of Pacific and Asian Studies, The Australian National University
Year: 2020

description: This paper focuses on tourism in Papua New Guinea (PNG) and a range of challenges that hinder the progress of tourism development. Over the years, tourism has seen continued growth and increasing expansion to become one of the leading and fastest growing economic sectors across the globe (Mihalic 2014; Rayel et al. 2014; SPTO 2018). Modern tourism is directly connected to developmental progress and includes an increasing number of new sites being developed as tourist destinations (Mihalic 2014; Rayel et al. 2014; UNWTO 2016). With its vast and untouched natural environment, PNG has a great deal of potential as a tourist destination (Rayel et al. 2014). However, tourism visitation to PNG in the last few years has been relatively low compared to smaller Pacific Island countries (Rayel et al. 2014; Sumb 2017). In 2006, the PNG Tourism Promotion Authority (PNG TPA) released the Papua New Guinea Tourism Sector Review and Master Plan (2007–2017), the aim of which was to bolster tourism growth.The PNG TPA identified a number of factors that dissuaded potential tourists from visiting such as insufficient infrastructure, concerns about adequate health services and the dangers posed to tourists by criminal activities (Basu 2000; Bhanugopan 2001; PNG TPA 2006; Rayel et al. 2014). The objective of this paper is to investigate, identify and discuss the factors that deter tourists from visiting PNG
Uncertainty-Aware prediction model
Creators: name: Heydari, Mohammad
Publisher: name: Zenodo
Year: 2020
Subjects: Uncertainty-Aware prediction model

description: 1- Uncertainty.ipynp: Python source code file in which prediction models are trained and built using a dataset (LD.xlsx). The code uses pandas library to import the dataset and build prediction models (Decision Tree, SVM, Logistic Regression, Naive Bayes, AdaBoost, Random Forest, K-NN, MLP, Gradient Boost and Voting Classifier) using sklearn library. All models are trained/built using 10-fold cross validation method. Moreover, a Gaussian noise function is used to add noise to the dataset. The code saves all prediction models and measures the performance of the models using accuracy, precission, recall and F1 metrics. It also draws ROC curves for each prediction model. 2- AdaBoostClassifier.sav: Designated prediction model (AdaBoost) 3- LD.xlsx: Low mobility dataset (Labeled) in Excel format consisting of uncertainty values for three attributes: Time, Location and Credential.
The Effects of Bacterial Surface Adsorption and Exudates on HgO Precipitation
Creators: name: Nell, Ryan M.
name: Szymanowski, Jennifer E. S.
name: Fein, Jeremy B.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: The effects of nonmetabolic bacterial cell wall adsorption and the presence of bacterial exudates on the precipitation of mineral phases from solution is not well constrained experimentally. In this study, we measured the extent of Hg(II) removal from solution, in the presence and absence of nonmetabolizing cells of Bacillus subtilis in both Cl-free and Cl-bearing systems with Hg concentrations ranging from undersaturation to supersaturation with respect to montroydite [HgO(s)]. Total Hg molalities ranged from 10−5.00 to 10−2.00 M at pH 4.50 and 7.00; the ionic strength of the experiments was kept constant using 0.01 M NaClO4, and the wet mass of bacteria was held constant at 5 g/L for each biotic experiment. The biotic systems exhibited enhanced Hg(II) removal from solution relative to the abiotic controls in undersaturated conditions. However, thermodynamic modeling of the experimental systems strongly suggests that all of this Hg removal can be ascribed to Hg adsorption onto cell envelope functional groups. There was no evidence for enhanced Hg removal due to precipitation in bulk solutions that were undersaturated with respect to the solid phase. Under the highest total Hg concentrations studied in both the Cl-free and Cl-bearing systems, bacteria inhibit precipitation, maintaining high concentrations of Hg in solution. Cell-free, exudate-bearing control experiments suggest that aqueous complexation between Hg and the bacterially-produced exudates accounts for at least some of the precipitation inhibition. However, a comparison of total available binding sites on the exudates with the concentration of Hg in solution suggests that aqueous complexation alone can not account for the observed elevated final aqueous Hg concentrations in solution, and that the exudates likely exert a kinetic inhibition on the precipitation reaction as well.
KNOWLEDGE MANAGEMENT PRACTICES: A CASE STUDY IN THE BRAZILIAN INDUSTRY
Creators: name: Teixeira, Alex Volnei
name: Laurindo, Alisson
name: Keli Pereira
Publisher: name: figshare
Year: 2015
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: Theoretical Computer Science

description: This paper discusses the rapid transformation of industries in southern Brazil, due to management methodologies and the phenomenon of economic globalization. The study investigates the Corporate University (CU), as a management tool embedded in organizational planning, in order to identify the degree of importance perceived by managers to adopt this practice. Management with tools, methods and processes consistent with the organizational level, creates conditions for market positioning and search anticipate societal changes or crises inserting useful knowledge for the right organizational level without wasted effort in data collection. Based on these arguments, the research seeks to present a review of the practices of knowledge management, especially the corporate university and organizational management. The knowledge as an organizational resource stood out over the past two decades, especially with the advent of the Knowledge-Based View (KBV), which show a mixture between the knowledge management and business efficiency. The structure of these processes, tools and / or methods consolidates incorporating these practices of knowledge management (KM), among others the practice of UC. This applicability is a decisive factor for the organization, because knowledge is a strategic tool that leads to the increase in benefits, for creating sustainable competitive advantages. Methodologically the study was descriptive in nature applied quantitative approach and data collection was done through online survey - Survey. The technique adopted was non-probabilistic sampling and for sample calculation, we applied the formula for infinite population. 3073 industries of southern Brazil and 659 employees in strategic, tactical and operational level were researched. The questionnaires were returned by respondents electronically. Among the responses, over half of the respondents 54.55% considered the UC practice important and 25.97% consider, according to the non-parametric statistical Kruskal-Wallis, very important no significant difference in the response of this practice of knowledge management among the strategic, tactical and operational groups. In this setting, it was concluded that the practice (UC) is pretty important for strategic development of industries in southern Brazil, as well as reveals the concern by industry in protecting the knowledge (technology watch) and ensure the right of marketing your products or process improvements.
Comparison of a Wipe Method With and Without a Rinse to Recover Wall Losses in Closed Face 37-mm Cassettes used for Sampling Lead Dust Particulates
Creators: name: Ceballos, Diana M
name: King, Bradley
name: Beaucham, Catherine
name: Brueck, Scott E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Hematology
subject: 60506 Virology

description: Closed-face 37-mm polystyrene cassettes are often used for exposure monitoring of metal particulates. Several methods have been proposed to account for the wall loss in air sampling cassettes, including rinsing, wiping, within-cassette dissolution, and an internal capsule fused to the filter that could be digested with the filter. Until internal capsules replace filters, other methods for assessing wall losses may be considered. To determine if rinsing and wiping or wiping alone is adequate to determine wall losses on cassettes, we collected 54 full-shift area air samples at a battery recycling facility. We collected six replicate samples at three locations within the facility for three consecutive days. The wall losses of three replicate cassettes from each day-location were analyzed following a rinse and two consecutive wipes. The wall losses of the other three replicates from each day-location were analyzed following two consecutive wipes only. Mixed-cellulose ester membrane filter, rinse, and wipes were analyzed separately following NIOSH Method 7303. We found an average of 29% (range: 8–54%) recovered lead from the cassette walls for all samples. We also found that rinsing prior to wiping the interior cassette walls did not substantially improve recovery of wall losses compared to wiping alone. A rinse plus one wipe recovered on average 23% (range: 13–33%) of the lead, while one wipe alone recovered on average 21% (range: 16–22%). Similarly, we determined that a second wipe did not provide substantial additional recovery of lead (average: 4%, range: 0.4–19%) compared to the first wipe disregarding the rinse (average: 18%, range: 4–39%). We concluded that when an internal capsule is not used, wall losses of lead dust in air sampling cassettes can be adequately recovered by wiping the internal wall surfaces of the cassette with a single wipe.
The Effects of Bacterial Surface Adsorption and Exudates on HgO Precipitation
Creators: name: Nell, Ryan M.
name: Szymanowski, Jennifer E. S.
name: Fein, Jeremy B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: The effects of nonmetabolic bacterial cell wall adsorption and the presence of bacterial exudates on the precipitation of mineral phases from solution is not well constrained experimentally. In this study, we measured the extent of Hg(II) removal from solution, in the presence and absence of nonmetabolizing cells of Bacillus subtilis in both Cl-free and Cl-bearing systems with Hg concentrations ranging from undersaturation to supersaturation with respect to montroydite [HgO(s)]. Total Hg molalities ranged from 10−5.00 to 10−2.00 M at pH 4.50 and 7.00; the ionic strength of the experiments was kept constant using 0.01 M NaClO4, and the wet mass of bacteria was held constant at 5 g/L for each biotic experiment. The biotic systems exhibited enhanced Hg(II) removal from solution relative to the abiotic controls in undersaturated conditions. However, thermodynamic modeling of the experimental systems strongly suggests that all of this Hg removal can be ascribed to Hg adsorption onto cell envelope functional groups. There was no evidence for enhanced Hg removal due to precipitation in bulk solutions that were undersaturated with respect to the solid phase. Under the highest total Hg concentrations studied in both the Cl-free and Cl-bearing systems, bacteria inhibit precipitation, maintaining high concentrations of Hg in solution. Cell-free, exudate-bearing control experiments suggest that aqueous complexation between Hg and the bacterially-produced exudates accounts for at least some of the precipitation inhibition. However, a comparison of total available binding sites on the exudates with the concentration of Hg in solution suggests that aqueous complexation alone can not account for the observed elevated final aqueous Hg concentrations in solution, and that the exudates likely exert a kinetic inhibition on the precipitation reaction as well.
The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.
Creators: name: Kelly, Joanna R
name: Martini, Silvia
name: Brownlow, Nicola
name: Dhira Joshi
name: Federico, Stefania
name: Jamshidi, Shirin
name: Kjaer, Svend
name: Lockwood, Nicola
name: Khondaker Miraz Rahmen
name: Fraternali, Franca
name: Parker, Peter J
name: Soliman, Tanya N
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Biochemistry & Proteomics
Signalling & Oncogenes
Structural Biology & Biophysics
Cell Biology
Cell Cycle & Chromosomes
Chemical Biology & High Throughput

description: The Aurora B abscission checkpoint delays cytokinesis until resolution of DNA trapped in the cleavage furrow. This process involves PKCε phosphorylation of Aurora B S227. Assessing if this PKCε-Aurora B module provides a more widely exploited genome-protective control for the cell cycle, we show Aurora B phosphorylation at S227 by PKCε also occurs during mitosis. Expression of Aurora B S227A phenocopies inhibition of PKCε in by-passing the delay and resolution at anaphase entry that is associated with non-disjunction and catenation of sister chromatids. Implementation of this anaphase delay is reflected in PKCε activation following cell cycle dependent cleavage by caspase 7; knock-down of caspase 7 phenocopies PKCε loss, in a manner rescued by ectopically expressing/generating a free PKCε catalytic domain. Molecular dynamics indicates that Aurora B S227 phosphorylation induces conformational changes and this manifests in a profound switch in specificity towards S29 TopoIIα phosphorylation, a response necessary for catenation resolution during mitosis.
Optimal experimental plan for multi-level stress testing with Weibull regression under progressive Type-II extremal censoring
Creators: name: Hon Keung Tony Ng
name: İsmail Kınacı
name: Coşkun Kuş
name: Chan, Ping Shing
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: In the design of constant-stress life-testing experiments, the optimal allocation in a multi-level stress test with Type-I or Type-II censoring based on the Weibull regression model has been studied in the literature. Conventional Type-I and Type-II censoring schemes restrict our ability to observe extreme failures in the experiment and these extreme failures are important in the estimation of upper quantiles and understanding of the tail behaviors of the lifetime distribution. For this reason, we propose the use of progressive extremal censoring at each stress level, whereas the conventional Type-II censoring is a special case. The proposed experimental scheme allows some extreme failures to be observed. The maximum likelihood estimators of the model parameters, the Fisher information, and asymptotic variance–covariance matrices of the maximum likelihood estimates are derived. We consider the optimal experimental planning problem by looking at four different optimality criteria. To avoid the computational burden in searching for the optimal allocation, a simple search procedure is suggested. Optimal allocation of units for two- and four-stress-level situations is determined numerically. The asymptotic Fisher information matrix and the asymptotic optimal allocation problem are also studied and the results are compared with optimal allocations with specified sample sizes. Finally, conclusions and some practical recommendations are provided.
Multivariate-Sign-Based High-Dimensional Tests for the Two-Sample Location Problem
Creators: name: Feng, Long
name: Changliang Zou
name: Zhaojun Wang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: This article concerns tests for the two-sample location problem when data dimension is larger than the sample size. Existing multivariate-sign-based procedures are not robust against high dimensionality, producing tests with Type I error rates far away from nominal levels. This is mainly due to the biases from estimating location parameters. We propose a novel test to overcome this issue by using the “leave-one-out” idea. The proposed test statistic is scalar-invariant and thus is particularly useful when different components have different scales in high-dimensional data. Asymptotic properties of the test statistic are studied. Compared with other existing approaches, simulation studies show that the proposed method behaves well in terms of sizes and power. Supplementary materials for this article are available online.