Title: Primary recurrence rates and patient characteristics in Dupuytren’s disease: A systematic review and Meta-Analysis
Creators: name: Elsewify, Omar
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences

description: Research Question: In patients undergoing treatment with Collagenase Clostridium histolyticum injections (CCH), percutaneous needle fasciotomy (NF) or open fasciectomy following diagnosis of Dupuytrens disease, what are the rates of recurrence in these patients? Searches: A comprehensive search of major bibliographic databases Medline (via Ovid), Embase (via Ovid) and Cochrane library was conducted to identify relevant studies. Databases were searched from inception. The main search strategy was developed on Medline. The vocabulary and syntax of the Medline strategy was tailored and adapted to the other databases. No restrictions were applied (e.g., language, year, status of publication). We revied the reference lists of included studies to identify any other relevant studies. Keywords and index/subject terms were joined by Boolean operators “AND” or “OR”. Last, we downloaded all the retrieved citations to an EndNote library for deduplication. The search strategy is provided in appendix 1. Types of studies to be included: Prospective and retrospective studies, randomized controlled trials, case-series, case-control studies, and case reports were eligible for inclusion. Systematic reviews, meta-analyses, letters to the editor, viewpoints, commentaries, abstracts not traced to full text were excluded. Condition of domain being studied: Dupuytrens contracture. This systematic review and meta-analysis were performed in accordance with the Preferred Reporting of Systematic Review and Meta-Analysis (PRISMA) guidelines. Participants/Population: Pediatric (&lt; 18 years old) or adult (≥ 18 years old) patients undergoing treatment for Dupuytrens disease. Intervention(s), exposure(s): Collagenase Clostridium histolyticum injections (CCH), percutaneous needle fasciotomy (NF) or open fasciectomy (OF) Comparator(s)/control: Studies which had no control group or that provided a control group (any type). Outcome(s): Recurrence rates and patient characteristics. Any other outcomes deemed relevant during extraction were included. Data extraction (selection and coding): Following the removal of duplicate citations, we transferred the EndNote library to Rayyan, an online systematic review software. Two reviewers independently screened the titles and abstracts of all the retrieved citations against prespecified eligibility criteria (see study eligibility above). Studies considered potentially eligible by either reviewer underwent full-text assessment. Any disagreements regarding study eligibility were resolved through consensus, and when necessary, through discussion with a third reviewer. One reviewer conducted the data extraction, with a piloted data extraction. The second reviewer reviewed the extracted data and reported any disagreements. Discrepancies were resolved through consensus, and when necessary, through discussion with a third reviewer. Risk of bias (quality) assessment: NA Strategy for data synthesis: We created summary tables which included study and sample characteristics as well as results. When possible, recurrence rates were assessed. Analysis of subgroups or subsets: Based on the available data, we decided that subgroup analyses was not feasible. Contact details for further information: Omar El Sewify Omar.Elsewify@gmail.com Organizational affiliation of the review: University of Montreal Review team members and their organizational affiliations: Xiya Ma. University of Montreal Omar Elsewify. Laval University Linda Zhu. University of Montreal Bruno Mastropasqua. University of Montreal Collaborators: Not applicable Type and method of review: Systematic review Anticipated or actual start date: January 2023 Anticipated completion date: December 2023 Funding sources/sponsors: None Conflicts of interest: None Language: English Country: Canada