cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The formation of gullies on Mars today
Creators: name: Dundas, Colin M.
name: McEwen, Alfred S.
name: Diniega, Serina
name: Hansen, Candice J.
name: Byrne, Shane
name: McElwaine, Jim N.
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Figures, animations and a summary table describing details of known gully activity.
title: ADCO, Privilèges de l'Ordre de Cîteaux en matière de succession (Fin XVe siècle), Cart. 176 (11 H 8), f. 0092
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Privilèges de l'Ordre de Cîteaux en matière de succession (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 176 (11 H 8), f. 0092, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Privilèges de l'Ordre de Cîteaux en matière de succession (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 176 (11 H 8), f. 0092, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
A Few Confusing Questions Regarding the Universe
Creators: name: Argos Panopty
Publisher: name: Zenodo
Year: 2020
Subjects: big-bang, expanding universe, time, space, observer, light

description: . If the universe began by expanding from the point of singularity, where would be the observer to record the expansion? Will it be placed inside or outside of the expanding universe? In other words, if there was an expansion, it was expansion in relation to what/whom?
Observation of Temperature-Dependent Capture Cross-Section for Main Deep-Levels in $β$-Ga2O3
Creators: name: Vasilev, A. A.
name: Kochkova, A. I.
name: Polyakov, A. Y.
name: Romanov, A. A.
name: Matros, N. R.
name: Alexanyan, L. A.
name: Shchemerov, I. V.
name: Pearton, S. J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Direct observation of capture cross-section is challenging due to the need of extremely short filling pulses in the two-gate Deep-Level Transient Spectroscopy (DLTS). Simple estimation of cross-section can be done from DLTS and Admittance Spectroscopy (AS) data, but it is not feasible to distinguish temperature dependence of pre-exponential and exponential parts of the emission rate equation with sufficient precision conducting a single experiment. This paper presents experimental data of deep-levels in $β$-Ga2O3 that has been gathered by our group since 2017. Based on the gathered data we propose a derivation of apparent activation energy ($E_a^m$) and capture cross-section ($σ_n^m$) assuming temperature dependent capture via multiphonon emission model, which resulted in strong correlation between $E_a^m$ and $σ_n^m$ according to Meyer-Neldel rule, which allowed us to estimate low- and high-temperature capture coefficients $C_0$ and $C_1$ as well as capture barrier $E_b$. It also has been shown that without considering the temperature dependence of capture cross-section, the experimental values of $σ_n$ are overestimated by 1-3 orders of magnitude. A careful consideration of the data also allows to be more certain identifying deep-levels by their "fingerprints" ($E_a$ and $σ_n$) considering two additional parameters ($E_{MN}$ and $σ_{00}$) and to verify the density functional theory (DFT) computation of deep-level recombination properties.
Supplementary Material
Creators: name: Anonymous Submission
Publisher: name: figshare
Year: 2017
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 80110 Simulation and Modelling
subject: FOS: Computer and information sciences

description: Supplementary Material of the Research article 'The impact of changes in day-care centres’ enrolment on
the dynamics of varicella transmission in France between
1991 and 2015'
Reliability and validity of the Montreal Cognitive Assessment’s auditory items (MoCA-22)
Creators: name: Lord, Alinda Rafaela
name: Amitrano, Nicholas R.
name: González, David Andrés
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Objective: To evaluate the latent structure, internal consistency, convergent and discriminant validity, diagnostic accuracy, and criterion validity of the Montreal Cognitive Assessment’s auditory items (MoCA-22), which has previously been evaluated in small samples if at all. Methods: 11,284 participants completed the MoCA over 1–2 visits to an Alzheimer Disease Research Center (Mage = 69.2, Meducation = 15.9, 57.6% women, 92.4% non-Hispanic white). MoCA-22 items were probed with alpha, omega, confirmatory factor analysis, and test-retest correlations. Scores were related to measures of neurocognition, daily functioning, behavioral-psychological symptoms (BPS), and vision performance for convergent-discriminant and criterion validity. Dementia stage was used to calculate area under the receiver operating characteristic (AUC-ROC) curves and cutoffs for mild cognitive impairment (MCI) and dementia. Results: A single-factor had good fit (CFI = .961; TLI = .945; RMSEA = .061; SRMR = .031), with good internal consistency (Omega total = .83) and test-retest consistency (ICC = .92 at 2.7 years). The strongest convergent correlations were with general cognition and executive functioning, while discriminant validity was demonstrated with its weakest and negative correlations being with BPS. There was strong classification accuracy in distinguishing MCI from normal cognition (AUC = .79; optimal cutoff point < 18), and mild-to-moderate dementia from MCI (AUC = .85; optimal cutoff point < 13). Furthermore, the MoCA-22 had negligible-to-small differences among those with and without vision limitations. Conclusions: These findings add to the evidence of the MoCA-22’s utility and it serves as a useful cognitive screening tool with sound reliability and validity.
No radiological and clinical advantages with patient-specific positioning guides in total knee replacement
Creators: name: Leeuwen, Justin A M J Van
name: Snorrason, Finnur
name: Röhrl, Stephan M
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Background and purpose — Although the use of patient-specific positioning guides (PSPGs) in total knee replacement (TKR) in theory is promising, the technique has not yet proven its superior- ity compared with the conventional method. We compared radio- logical alignment and clinical outcome between TKR performed with the use of PSPGs and the conventional operation method. Patients and methods — 3 hospitals participated in a prospec- tive trial. 109 patients were randomized to either the conventional method or to the use of PSPGs. Postoperatively a full-length standing anteroposterior radiograph and a postoperative CT scan were taken. On the CT scan the alignments were measured for both the femoral and tibial components in the frontal, sagit- tal, and axial plane. The Knee injury and Osteoarthritis Outcome Score (KOOS), the Eurocol-5D-3L (Eq5D) descriptive system and visual analogue scale (VAS), a pain score (NRS), and range of motion (ROM) were recorded preoperatively, and at 3 months, 1, and 2 years. The operation time and length of hospital stay were recorded. Results — 90 patients were available for postoperative CT mea- surements. A statistically significant difference was found between the conventional TKR instrumentation and the use of PSPGs for the frontal femoral (mean (SD) 0.6° (1.7) vs. –0.3° (2.2), CI 0.08 to 1.69) and tibial (–0.3° (1.5) vs. 0.9° (2.1), CI –1.98 to –0.44) compo- nent angles and for the tibial alignment in the sagittal plane (–3.8° (3.0) vs. –2.2° (2.5), CI –2.72; –0.42). The proportions of outliers were similar between the groups as well as the hip–knee–ankle angle, the KOOS sub scores, the Eq5D, pain (NRS), ROM, opera- tion time, and length of hospital stay. Interpretation — The use of PSPGs requires a preoperative CT scan or MRI and the guides have an additional cost. As this study was not able to prove any extra benefit of the use of PSPGs we recommend the conventional operation method for TKR.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Beaune et du Beaunois (XVe siècle), Cart. 174 (11 H 79), 56 pages, f. 0021
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Beaune et du Beaunois (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 174 (11 H 79), 56 pages, f. 0021, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Beaune et du Beaunois (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 174 (11 H 79), 56 pages, f. 0021, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 3 of Single-molecule long-read sequencing analysis improves genome annotation and sheds new light on the transcripts and splice isoforms of Zoysia japonica
Creators: name: Guan, Jin
name: Yin, Shuxia
name: Yue, Yuesen
name: Liu, Lingyun
name: Guo, Yidi
name: Zhang, Hui
name: Fan, Xifeng
name: Teng, Ke
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3. KEGG enrichment of in the genespossessed AS events.
D.3.2: Flexible Network Specification and Architecture
Creators: name: Haetty Birger
name: Schulz Steffen
name: Wimmer Markus
Publisher: name: Zenodo
Year: 2019

description: Hybrid connectivity allows an ITS Station to use more than one radio access technologies, both cellular and ad-hoc radio access technologies, to provide or use vehicular services. Multiple radio access technologies can be applied in an OBU, which then decides which access technology to use. A service deployed e.g., in an RSU can also use multiple radio access technologies. In this case, it can provide its service to OBUs in vehicles which either have cellular (LTE/5G) or ad-hoc (ITS-G5) radio access technology implemented. Cellular radio networks are designed as multi-purpose networks. Hereby LTE is the dominant technology in Europe at the time being and for the next years. To provide real-time critical services close to a UE's point of attachment is a challenge in most existing operator’s infrastructures. This document outlines possible strategies how this can be achieved. This involves the use of edge computing and network slicing strategies developed for cellular radio networks like LTE. These strategies differ to what extend vehicular services can  be isolated from the traffic of other users,  be dynamically provided with the quality of service appropriate for the service;  be provided with IT and cloud computing at the edge of the radio access network; Hybrid connectivity provides the required level of redundancy, reliability and availability for higher levels of automated driving. In order to allow a more flexible deployment of cellular radio networks, different network strategies and architectures are proposed and discussed.
Perceived cognitive impairment is related to internalizing psychopathology but unrelated to objective cognitive performance among nongeriatric adults presenting for outpatient neuropsychological evaluation
Creators: name: Finley, John-Christopher A.
name: Cladek, Andrea
name: Gonzalez, Christopher
name: Brook, Michael
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Objective: This study investigated the relationship between perceived cognitive impairment, objective cognitive performance, and intrapersonal variables thought to influence ratings of perceived cognitive impairment. Method: Study sample comprised 194 nongeriatric adults who were seen in a general outpatient neuropsychology clinic for a variety of referral questions. The cognition subscale score from the WHO Disability Assessment Schedule served as the measure of perceived cognitive impairment. Objective cognitive performance was indexed via a composite score derived from a comprehensive neuropsychological battery. Internalizing psychopathology was indexed via a composite score derived from anxiety and depression measures. Medical and neuropsychiatric comorbidities were indexed by the number of different ICD diagnostic categories documented in medical records. Demographics included age, sex, race, and years of education. Results: Objective cognitive performance was unrelated to subjective concerns, explaining <1% of the variance in perceived cognitive impairment ratings. Conversely, internalizing psychopathology was significantly predictive, explaining nearly one-third of the variance in perceived cognitive impairment ratings, even after accounting for test performance, demographics, and number of comorbidities. Internalizing psychopathology was also highly associated with a greater discrepancy between scores on perceived and objective cognitive measures among participants with greater cognitive concerns. Clinically significant somatic symptoms uniquely contributed to the explained variance in perceived cognitive impairment (by ∼13%) when analyzed in a model with internalizing symptoms. Conclusions: These findings suggest that perceived cognitive impairment may be more indicative of the extent of internalizing psychopathology and somatic concerns than cognitive ability.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00619
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00619, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
New chemical constituents from the fruits of Zanthoxylum armatum and its in vitro anti-inflammatory profile
Creators: name: Zulfa Nooreen
name: Anant Kumar
name: Dnyaneshwar Umrao Bawankule
name: Sudeep Tandon
name: Mohd Ali
name: Xuan, Tran Dang
name: Ateeque Ahmad
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Chemical investigations on the fruits of Zanthoxylum armatum Roxb. (Rutaceae) led to the isolation of two new constituents characterised as 2α-methyl-2β-ethylene-3β-isopropyl-cyclohexan-1β, 3α-diol (1) and phenol-O-β-D-arabinopyranosyl-4′-(3″, 7″, 11″, 15″-tetramethyl)-hexadecan-1″-oate (2) along with known compounds m-methoxy palmityloxy benzene (3), acetyl phenyl acetate (4), linoleiyl-O-α-D-xylopyranoside (5), m-hydroxyphenoxy benzene (6) and palmitic acid (7). The chemical structures were established with the help of physical, chemical and spectroscopic methods. The anti-inflammatory potential of isolated compounds 1 and 2 was evaluated using in vitro target-based anti-inflammatory activity in LPS-stimulated primary peritoneal macrophages isolated from mice. Production of pro-inflammatory cytokines (TNF-α and IL-6) was significantly inhibited by the treatment of isolated compounds 1 and 2 in a dose-dependent manner.
Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs
Creators: name: Johanns, Vanessa C.
name: Ghazisaeedi, Fereshteh
name: Epping, Lennard
name: Semmler, Torsten
name: Lübke-Becker, Antina
name: Pfeifer, Yvonne
name: Bethe, Astrid
name: Eichhorn, Inga
name: Merle, Roswitha
name: Walther, Birgit
name: Wieler, Lothar H.
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: Escherichia coli
subject: zinc
subject: antimicrobial resistance
subject: pig
subject: heavy metal tolerance
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Strategies to reduce economic losses associated with post-weaning diarrhea in pig farming include high-level dietary zinc oxide supplementation. However, excessive usage of zinc oxide in the pig production sector was found to be associated with accumulation of multidrug resistant bacteria in these animals, presenting an environmental burden through contaminated manure. Here we report on zinc tolerance among a random selection of intestinal Escherichia coli comprising of different antibiotic resistance phenotypes and sampling sites isolated during a controlled feeding trial from 16 weaned piglets: In total, 179 isolates from “pigs fed with high zinc concentrations” (high zinc group, [HZG]: n = 99) and a corresponding “control group” ([CG]: n = 80) were investigated with regard to zinc tolerance, antimicrobial- and biocide susceptibilities by determining minimum inhibitory concentrations (MICs). In addition, in silico whole genome screening (WGSc) for antibiotic resistance genes (ARGs) as well as biocide- and heavy metal tolerance genes was performed using an in-house BLAST-based pipeline. Overall, porcine E. coli isolates showed three different ZnCl2 MICs: 128 μg/ml (HZG, 2%; CG, 6%), 256 μg/ml (HZG, 64%; CG, 91%) and 512 μg/ml ZnCl2 (HZG, 34%, CG, 3%), a unimodal distribution most likely reflecting natural differences in zinc tolerance associated with different genetic lineages. However, a selective impact of the zinc-rich supplemented diet seems to be reasonable, since the linear mixed regression model revealed a statistically significant association between “higher” ZnCl2 MICs and isolates representing the HZG as well as “lower ZnCl2 MICs” with isolates of the CG (p = 0.005). None of the zinc chloride MICs was associated with a particular antibiotic-, heavy metal- or biocide- tolerance/resistance phenotype. Isolates expressing the 512 μg/ml MIC were either positive for ARGs conferring resistance to aminoglycosides, tetracycline and sulfamethoxazole-trimethoprim, or harbored no ARGs at all. Moreover, WGSc revealed a ubiquitous presence of zinc homeostasis and – detoxification genes, including zitB, zntA, and pit. In conclusion, we provide evidence that zinc-rich supplementation of pig feed selects for more zinc tolerant E. coli, including isolates harboring ARGs and biocide- and heavy metal tolerance genes – a putative selective advantage considering substances and antibiotics currently used in industrial pork production systems.
Spatial scheduling strategy for irregular curved blocks based on the modified genetic ant colony algorithm (MGACA) in shipbuilding
Creators: name: Ge, Yan
name: Aimin Wang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This paper proposes a scheduling strategy for irregular curved blocks to address the complex spatiotemporal coupling scheduling problem related to the entered time, the entered sequence, the setting positions and the rotated angles for the curved blocks in a shipbuilding yard. The strategy presents a makespan-based curved blocks – classification and selection rule to fulfil the programming time for the entry of the curved blocks into the workplace and realises the suppression on the delay. Useless stepping search of curved blocks in occupied workplace is avoided by combining the lowest centre-of-gravity rule with the calculation method of the remained workplace proposed in this paper. A modified genetic ant colony algorithm was proposed, which apply the ease to premature characteristics of GA and the excellent local optimisation ability of ACO, to let and promote the algorithm falls into local optimum. Then the large-scale and full-range mutation will be implemented to make the algorithm jump out of the original local optimisation to search more local optimal solutions so that the global optimal solution can be achieved. Finally, a software system for algorithm verification was developed which conducts the comparative analysis of the algorithms and verifies the validity of the algorithm proposed.
Studying the variations of the cyclotron line in Cen X-3 using Insight-HXMT
Creators: name: Liu, Qi
name: Wang, Wei
name: Yang, Wen
name: Chen, Xiao
name: Wu, Hanji
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate the cyclotron resonant scattering features (CRSFs) of the accreting X-ray pulsar Cen X-3 and significantly detect the 29 keV cyclotron line features in the hard X-ray averaged spectroscopy studies based on the recent Insight-HXMT observations in 2022, when Cen X-3 has X-ray luminosity $L_{\rm X} > \sim 5 \times 10^{37}$ erg\ s$^{-1}$ in the bands of 2 -- 60 keV. We do not find a harmonic line in the average spectra based on different continuum models. We showed that the CRSF energies have no correlation with time or luminosity in the average spectra. In addition, by performing a pulse phase-dependent spectral analysis, we revealed the fundamental line with the centroid energy ranging from 25 to 29 keV with a high significance over the spin phases. The evolution of the cyclotron line centroid energies over pulse phase is similar to the shape of pulse profiles, illustrating a positive correlation between the energy of CRSFs and the pulse phase flux.
description: 10 pages, 7 figures
Synthesis of new pyridothienopyrimidinone and pyridothienotriazolopyrimidine derivatives as pim-1 inhibitors
Creators: name: El-Nassan, Hala B.
name: Naguib, Bassem H.
name: Engy A. Beshay
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Three series of 2-arylpyridothieno[3,2-d]pyrimidin-4-ones 3a–j, pyridothienotriazolopyrimidines 6–8 and 4-imino-pyridothieno[3,2-d]pyrimidines 9a,b were prepared to improve the pim-1 inhibitory activity of the previously reported 2-arylpyridothieno[3,2-d]pyrimidin-4-ones. All the test compounds showed highly potent pim-1 inhibition with IC50 in the range of 0.06–1.76 µM. No significant difference was detected between the pim-1 inhibitory activity of the 4-pyrimidinone and the 4-imino (=NH) or the cyclised triazolopyrimidine derivatives. The most active compounds were tested for their cytotoxic activity on MCF7 and HCT116 and showed potent activity on both the cell lines.
A systematic review of cognition in idiopathic intracranial hypertension
Creators: name: Richey, Lisa N.
name: Coronel, Marcelo X. Abad
name: Bryant, Barry R.
name: Esagoff, Aaron I.
name: White, Jacob
name: Cranston, Christopher C.
name: Peters, Matthew E.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Neuroscience
Science Policy
Mental Health

description: Background: Cognitive disturbance is not pathognomonic of idiopathic intracranial hypertension (IIH), and therefore is not routinely assessed unless it presents as a major complaint. Consequently, cognition has been slow to gain substantial traction in IIH-related research, despite its notable impact on a subset of patients. We completed a systematic review of the literature examining the neurocognitive profile of patients with IIH. Methods: A PRISMA compliant literature search was conducted in Ovid Medline, PubMed, PsycInfo, Embase, Web of Science, Cochrane, Cinahl, and Scopus databases. The initial query yielded 1376 unique articles. These articles were narrowed to those including empirical analyses of cognitive assessment in adult patients with IIH. Results: A final cohort of nine articles resulted, comprising the findings from 309 patients with IIH and 153 healthy control subjects. Although there was considerable variability in methodology particularly with respect to cognitive assessment, fairly consistent deficits were observed across studies in the domains of processing speed, working memory, sustained and complex attention, set-shifting, and confrontation naming. Body mass index and body weight were not associated with cognitive performance. Pertinent limitations of the literature were identified, most notably failure to report trial-level cognitive testing data, the need for more comprehensive testing batteries with less reliance on screening tools, and not controlling for variables that may impact cognition. Conclusions: A more complete understanding of the cognitive profile in patients with idiopathic intracranial hypertension could lead to the increased ­relevance of cognitive screening in disease management, and therefore more appropriate neuropsychological referral, earlier identification of functional limitations, and targeted neurorehabilitation.
Handicraft art leisure activities and cognitive reserve
Creators: name: Mashinchi, Genna M.
name: McFarland, Craig P.
name: Hall, Stuart
name: Strongin, Dawn L.
name: Williams, Gary A.
name: Cotter, Kelly A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Mental Health

description: ObjectiveOlder individuals face a higher likelihood of developing dementia. The rate of cognitive decline resulting from dementia is not equivalent for all, as some patients with dementia are able to function independently longer than others, despite having similar disease burden. The cognitive reserve (CR) theory provides one explanation for the differing rate of decline. CR suggests that there are factors—most notably, educational attainment and occupational attainment—that can protect against the cognitive decline. Although the beneficial effects of these notable CR factors are clear, not all are easily modifiable. Participation in leisure activities may represent a more easily modifiable factor. Some research hints at beneficial effects of leisure activities, although specific leisure activities have not been well examined. The present study examined the relations between handicraft art leisure activities (HALAs) and multiple cognitive domains. MethodArchival WAIS-IV and demographic data for 50 California retirement community residents were examined. ResultsHALA participation accounted for statistically significant variance in working memory performance (R2 = .40, β = .24%) over and above the established CR factors of age, depression, educational attainment, and occupational attainment. In addition, HALA participation was related to a better ability to perform abstract visual information tasks (Block Design subtest, r = .28, p = .05) and non-verbal reasoning tasks (Visual Puzzles subtest, r = .38, p = .008). ConclusionsHALA participation among older adults could contribute to the retention of cognitive function, supporting the role of HALA participation as a CR factor.
Multiple-physiological benefits of bird’s nest fern (Asplenium australasicum) frond extract for dermatological applications
Creators: name: Zeng, Wen-Wen
name: Lih-Shiuh Lai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: p-coumaric acid and fucose-rich polysaccharide have been studied for many bio-functions in skin including cutaneous protection from oxidative damage and antiageing, respectively, as well as wound healing. The physiological activities of various bird’s nest fern extracts (BNFE), containing considerable fucose-rich mucilage and p-coumaric acid, on fibroblast and human skin were first investigated. BNFE with higher polysaccharide content generally contributed to a better moisture holding capability. Furthermore, BNFE showed pronouncedly enhancing effect on collagen production and growth of fibroblast (NIH-3T3), clinical trial results revealed that the emulsions with 1% BNFE showed good moisturising effect and improved the elasticity of human skins effectively. The potential of BNFE for cosmetics and medical applications such as natural moisturiser, antiageing and wound repairing was possibly related to the fucose-rich mucilage and various phenolic compounds including p-coumaric acid in BNFE.
Nano-fumed silica as a novel pollutant that inhibits the algicidal effect of p-hydroxybenzoic acid on Microcystis aeruginosa
Creators: name: Xiaofeng Jiang
name: Shengpeng Zuo
name: Liangtao Ye
name: Wenxiu Hong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Nanomaterials and/or contaminants are becoming more common in the developing world, but their effects on interspecific interactions are rarely reported, particularly in aquatic ecosystems. Thus, the present study determined the effects of the novel pollutant nano-fumed silica (NFS) on algal control by a macrophyte via the allelochemical p-hydroxybenzoic acid in a microcosm test. The allelochemical p-hydroxybenzoic acid caused significant decreases in chlorophyll a, but increased the amount of superoxide anion radicals (O2∙−) and the electric conductivity in Microcystis aeruginosa. The 50% inhibitory concentration (IC50) for p-hydroxybenzoic acid was 0.919 mmol/L in microalga during the exponential phase. Interestingly, NFS at 100–1600 mg/L had clear stimulatory effects on M. aeruginosa. When NFS at 800 mg/L was combined with different concentrations of p-hydroxybenzoic acid, the IC50 for p-hydroxybenzoic acid was 1.045 mmol/L. Thus, NFS significantly reduced the algicidal effect exhibited by p-hydroxybenzoic acid on M. aeruginosa. Furthermore, NFS might act as a silicon nutrient and enhance allelopathic resistance in M. aeruginosa to inhibit the algicidal effects of macrophytes via allelopathy. These findings suggest that before algal control is considered using macrophyte allelopathy, it is essential to remove the pollutant NFS from polluted lakes.
TREAT trial renal biomarker analysis report
Creators: name: Flohr, Carsten
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 429999
subject: Other health sciences not elsewhere classified

description: The TREatment of severe Atopic Eczema (TREAT) trial evaluated the impact of CyA versus MTX on severe atopic dermatitis in children and young people, with 103 participants randomised between May 2016 and February 2019, 52 to CyA and 51 to MTX. Primary outcomes were changes in the Objective Severity Scoring of Atopic Dermatitis (o-SCORAD) at 12 weeks and the time to first significant flare following treatment cessation at 36 weeks. The trial reported that CyA at a dose of 4mg/kg/day demonstrated a greater improvement in severity scoring at 12 weeks, but this was reversed in favour of MTX at a dose of 0.4mg/kg/week by weeks 48 and 60.
While MTX is not regarded as being nephrotoxic in low doses, CyA and MTX can both affect kidney function and frequent renal profile measurements are routinely undertaken as part of safety monitoring. Such standard tests are, however, not very sensitive, as serum creatinine may change late in the evolution of acute kidney injury (AKI).
Cystatin-c (CysC) may identify AKI earlier in children, and a combination strategy incorporating serum creatinine, CysC and urinary N-acetyl-beta-D-glucosaminidase (UNAG) measurement has also been shown to identify AKI earlier. UNAG is an enzyme found in the lysosomes of proximal tubule epithelial cells, and therefore a raised level likely reflects proximal tubular damage. Symmetric dimethylarginine (SDMA) has also been identified as a clinically useful biomarker for chronic kidney disease (CKD) and can be raised in CKD irrespective of the creatinine level.To comprehensively assess the impact of CyA versus MTX on renal function, our initial study protocol included an evaluation of both functional (serum creatinine, SDMA, CysC) and kidney injury (UNAG) markers at baseline, weeks 2, 12, 36 (9 months on treatment from baseline) and 60 (6 months off treatment). Two outcomes were newly defined. The first was the change in markers across time points and between treatment arms, using linear mixed models including a random intercept to allow for within-participant correlations at different visits. The covariates in the models were the baseline value and an interaction between treatment group and visit in order to estimate the treatment effect at each time point.
Screening for post-stroke neurocognitive disorders in diverse populations: A systematic review
Creators: name: Gangaram-Panday, Shonimá G.
name: Zhou, Yanyao
name: Gillebert, Céline R.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Objective: Although neurocognitive disorders (NCD) are common post-stroke, many populations do not have adapted cognitive screens and cut-offs. We therefore reviewed the appropriateness of the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and Oxford Cognitive Screen (OCS) for diagnosing NCD in culturally diverse stroke populations. Method: Using an extensive search string, diagnostic accuracy studies for MMSE, MoCA and OCS in the stroke population were retrieved from four databases. We compared translations and adaptations, adjustments in scores and cut-offs, and their diagnostic accuracy. Results: The search resulted in 28 MMSE, 39 MoCA and 5 OCS-studies in 13 western, educated, industrialized, rich and democratic (WEIRD) and 4 other countries. There was a lack of studies on South-American, African, and non-Chinese-Asian populations. All three tests needed adaptation for less WEIRD populations and populations with languages with non-Latin features. Optimal MMSE and OCS subtest cut-offs were similar across WEIRD and less WEIRD populations, whereas optimal MoCA cut-offs appeared lower for less WEIRD populations. The use of adjusted scores resulted in different optimal cut-offs or similar cut-offs with better accuracy. Conclusions: MoCA, MMSE and OCS are promising tools for diagnosing post-stroke-NCD. For culturally diverse populations, translation, adaptation and adjusted scores or cut-offs are necessary for diagnostic accuracy. Available studies report scarcely about their sample’s cultural background and there is a lack of diagnostic accuracy studies in less WEIRD or culturally diverse populations. Future studies should report more cultural characteristics of their sample to provide better insight into the tests’ accuracy in culturally diverse populations.
Measuring mindreading in preschoolers: The perspective battery (PERBAT)
Creators: name: Conson, Massimiliano
name: Siciliano, Mattia
name: Zappullo, Isa
name: Baiano, Chiara
name: Trojano, Luigi
name: Salzano, Sara
name: Santangelo, Gabriella
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: The capacity to take another person’s visual perspective is pivotal for solving mindreading tests, such as Theory of Mind (ToM) tasks, but most of them heavily rely on domain-general abilities (e.g., language, executive functions). Here we present a novel battery of visual perspective-taking tests for child neuropsychological assessment, the Perspective Battery (PERBAT), which poses a limited load on domain-general abilities. The battery includes four tests: i) Block Building; ii) Hide and Seek; iii) Deceptive Figures; iv) Double-Sided Shelf. We administered the PERBAT to 126 typically developing preschoolers (65 males; 3-6-year-old); the participants also performed classical tests of social cognition, language, and nonverbal abstract reasoning. The scores of all the PERBAT tests were significantly and positively related with age and scores of the classical social cognition tests, but not with scores of the language and nonverbal abstract reasoning tests. The PERBAT could represent a useful neuropsychological tool providing a comprehensive assessment of visual perspective-taking skills in preschool children. Future investigation is needed to examine the validity of the PERBAT with neurotypical samples across countries, race, ethnicity, and language as well as with clinical populations. Longitudinal studies are also encouraged to examine whether early visual perspective-taking weaknesses are associated with later development of mindreading skills.
Evaluating functional abilities within the context of memory assessment: A practice survey of neuropsychologists
Creators: name: Shaikh, Komal T.
name: Bolton, Kathryn
name: Shaikh, Umar
name: Troyer, Angela K.
name: Rich, Jill B.
name: Vandermorris, Susan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Objective: Functioning in daily life is an important consideration when differentiating between individuals with normal cognition, mild neurocognitive disorder, and major neurocognitive disorder. Despite this, there is no gold standard measurement approach for assessing functional abilities and few guidelines on how to do so. The objective of this study was to examine neuropsychologists’ practices regarding the assessment of functional abilities across the spectrum of memory ability. Method: A total of 278 psychologists who routinely conduct neuropsychological assessments completed an online survey (estimated 15% response rate) querying their practices and perspectives with respect to the assessment of functional abilities. Results: Respondents identified that changes to several components of daily functioning, including activities of daily living, were important when evaluating functional abilities. Respondents reported utilizing a variety of instruments to assess functioning, with an overwhelming majority indicating the use of semi-structured interviews. Although most respondents are satisfied with existing tools, a quarter of respondents felt strongly that there was a need for more instruments of everyday functioning. Respondents further indicated that their recommendations to patients, particularly regarding compensatory strategies and follow-up with other professionals, were informed by results of their functional assessment. Conclusions: Overall, our survey results indicate that neuropsychologists perceive multiple factors of daily life to be important considerations when evaluating functioning, use a variety of techniques to assess functioning, and perceive a need for more measures of functional abilities.
title: Синонимический ряд русских прилагательных с доминантой «общительный»: когнитивно-дискурсивный подход
Creators: name: Вэй, И
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье рассматриваются единицы синонимического ряда с доминантой «общительный» с позиций когнитивно-дискурсивного подхода, анализируются сходства и различия в семантике единиц, особенности их употребления в разных типах дискурса, сочетаемость, типичные ситуации употребления данных прилагательных.
D.3.1: ICT4CART Reference Architecture
Creators: name: Adaktylos, Anna
name: Allmer, Gottfried
name: Buchholz, Michael
name: Hätty, Birger
name: Lassoued, Yassine
name: Massot, Guillemette
name: Strohbeck, Jan
name: Vogl, Friedrich
name: Wimmer, Markus
Publisher: name: Zenodo
Year: 2019

description: The aim of the ICT4CART project is to design, implement and test in real-life conditions a versatile ICT infrastructure that will enable the transition towards higher levels of automation. It focuses on four high-value use cases: Smart Parking & IoT services, dynamic adaptation of vehicle automation level based on infrastructure information, intersection crossing (urban) & lane merging (highway), and Cross Border Interoperability. Work Package 3 (WP3) builds on the findings of WP2, which includes the specification of the use cases (D2.1), the analysis of market needs (D2.2) and the system requirements (D2.3). Within Task 3.1 of WP3, the ICT4CART Reference Architecture was developed, which is reported in this document. The ICT4CART Reference Architecture will be the basis for the subsequent Tasks 3.2, 3.3 and 3.4, where the key aspects of Flexible Networks, IT Environment, and Cyber-Security & Data Privacy will be refined. Their findings will be reported in the deliverables D3.2, D3.3 and D3.4, respectively. This document describes the ICT4CART Reference Architecture that is used in the ICT4CART project to implement all of the project use cases (see D2.1). First, the Introduction in Section 1 describes the aims of ICT4CART, i.e. the design and deployment of the ICT4CART technologies on the test sites covering all use cases. Section 2 contains the description of the high-level architecture, which aims to not only encompass the ICT4CART use cases and scenarios, but also to be general enough to be re-used for new, different use cases in other projects as well as in the deployment of ICT-based ITS applications. It is followed by descriptions of different views of the architecture, which highlight certain aspects of the architecture. First, in Section 3, a functional view on the architecture is presented, which shows and describes the different functional components that are used in the project. Section 4 describes the types of data that can be transmitted in communication with the IT environment as well as the typical data flows. Then, in Section 5, a communication view is described, which outlines the different communication technologies used in the project (Ad-hoc-networks, cellular networks, hybrid communication) and the approach to their implementation during this project. As finding solutions for Cyber-Security and Data Privacy is a key objective of the project, Section 6 describes how the highlevel architecture can be enhanced with additional security and privacy components to achieve this objective. Finally, Section 7 concludes the document with a summary of the main aspects of the ICT4CART reference architecture.
New chemical constituents from the fruits of Zanthoxylum armatum and its in vitro anti-inflammatory profile
Creators: name: Zulfa Nooreen
name: Anant Kumar
name: Dnyaneshwar Umrao Bawankule
name: Sudeep Tandon
name: Mohd Ali
name: Xuan, Tran Dang
name: Ateeque Ahmad
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Chemical investigations on the fruits of Zanthoxylum armatum Roxb. (Rutaceae) led to the isolation of two new constituents characterised as 2α-methyl-2β-ethylene-3β-isopropyl-cyclohexan-1β, 3α-diol (1) and phenol-O-β-D-arabinopyranosyl-4′-(3″, 7″, 11″, 15″-tetramethyl)-hexadecan-1″-oate (2) along with known compounds m-methoxy palmityloxy benzene (3), acetyl phenyl acetate (4), linoleiyl-O-α-D-xylopyranoside (5), m-hydroxyphenoxy benzene (6) and palmitic acid (7). The chemical structures were established with the help of physical, chemical and spectroscopic methods. The anti-inflammatory potential of isolated compounds 1 and 2 was evaluated using in vitro target-based anti-inflammatory activity in LPS-stimulated primary peritoneal macrophages isolated from mice. Production of pro-inflammatory cytokines (TNF-α and IL-6) was significantly inhibited by the treatment of isolated compounds 1 and 2 in a dose-dependent manner.