cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stochastic modelling of regulation strategies in stem cell populations
Creators: name: García-Tejera, Rodrigo
Publisher: name: The University of Edinburgh
Year: 2024
Subjects: Stochastic modelling
stem cell populations
regulation strategies in stem cell populations
modelling stem cell populations
heterogeneous stem cell states

description: Healthy tissues exhibit remarkable resilience, maintaining functionality through continuous renewal of cells, and displaying an impressive regeneration capacity after injury. Achieving this demands the precise regulation of the tissue-resident stem cell numbers and their proliferation and differentiation rates. However, the mechanisms preventing the depletion or overgrowth of the stem cell pool and enabling regeneration remain elusive. Unravelling the regulation strategies of stem cell populations would shed light on tissue function and potential ways regulation can break down in disease. Recent years witnessed technological advances that enabled the examination of tissues with an unprecedented level of detail. This revealed that there is a degree of randomness in the fate determination after stem cell division, and yet tissues manage to maintain a correct proportion of each cell type during homeostasis. Understanding how stem cell populations integrate environmental cues and communicate with other cell populations to maintain and regenerate tissues in the presence of randomness requires the development of mathematical models capturing homeostasis and regeneration as collective phenomena. This thesis addresses various challenges of modelling stem cell populations in the presence of regulatory mechanisms. Can we propose stochastic models for stem cell populations with regulatory mechanisms in a mathematically tractable fashion? Stem cell populations can be composed of fewer than ten cells, how can we provide accurate descriptions of their behaviour in such cases? What are the main signatures of different regulation strategies at the population level? Can we use them to argue for or against their presence in different tissues? First, we propose and investigate the dynamics of a stochastic model for stem cell populations in the presence of regulation through competition for niche access, prevalent in many tissues. Our model effectively captures the essential elements of competition for niche access while remaining mathematically tractable. We characterise the behaviours of the model analytically and numerically, addressing challenges such as non-Gaussian fluctuations, extinction dynamics or finite-size effects.
The importance of communication in improving service delivery and service quality in the Malaysian hotel industry
Creators: name: Lahap, J.
name: O'Mahony, Barry
name: Dalrymple, John
Publisher: name: Swinburne
Year: 2024

description: Travel and Tourism industry is an important sector that contributes at least 9 per cent of the world's GDP, employs over 255 million people worldwide and represents 8 per cent of the global workforce (World Travel and Tourism, 2012). The industry makes a significant contribution to the economic development of many nations with some countries dependent on tourism as a catalyst for growth and development. This is the case in Malaysia where the tourism industry has been accommodating large numbers of tourists, arriving for business or holiday purposes as well as transitory passengers' en-route to other destinations. In 2013, the hospitality and tourism generated MYR 60.6 billion (USD 20 billion) towards the Malaysian economy it was categorized among the most promising industry. In 2013, Kuala Lumpur was ranked the seventh (7th) most visited destination in the world. Therefore, the importance of maintaining the service quality in the hotel sector becomes the main issue. In this, it was identified that the Internal Market Orientation framework was known to have the ability to improve service delivery and as a result improving service quality. In Internal Market Orientation, 3 distinctive antecedents namely a) internal market intelligence generation, b) internal communication, and c) response to Intelligence, were found to be useful in improving service delivery. However, this paper will only focus on internal communication as the scope of Internal Market Orientation is quite extensive.
China's Engagement in Conflict and Post-Conflict Settings: The Quest for Stability
Creators: name: Mariani, Bernardo
Publisher: name: University of Edinburgh
Year: 2022
Subjects: Global Transitions
Peace Processes
China

description: This paper finds that China’s vision of addressing violent conflicts and security challenges differs substantially from those of Western countries. China seeks stability, rather than peace, and Chinese diplomats tend to avoid references to terms such as peacemaking and peacebuilding (with the exception of discussions around the UN). China’s economic development, and connectivity and trade needs – especially along the path of the Belt and Road Initiative – drive Chinese engagement in conflict and post-conflict settings. Once there, rather than actively pursuing peace, China seeks stability, especially in contexts where it has major financial and geostrategic interests.
A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and dementia using neuroimaging methods: Study characteristics and intervention efficacy
Creators: name: Steiner, Genevieve Z.
name: Mathersul, Danielle C.
name: MacMillan, Freya
name: Camfield, David
name: Klupp, Nerida L.
name: Seto, Sai W.
name: Huang, Yong
name: Hohenberg, Mark I.
name: Chang, Dennis H.
Publisher: name: Swinburne
Year: 2024

description: Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia. Six databases were searched for articles reporting on CMs, dementia, and neuroimaging methods. Data were extracted from 21/2,742 eligible full text articles and risk of bias was assessed. Nine studies examined people with Alzheimer's disease, 7 MCI, 4 vascular dementia, and 1 all-cause dementia. Ten studies tested herbal medicines, 8 vitamins and supplements, and 3 nootropics. Ten studies used electroencephalography (EEG), 5 structural magnetic resonance imaging (MRI), 2 functional MRI (fMRI), 3 cerebral blood flow (CBF), 1 single photon emission tomography (SPECT), and 1 positron emission tomography (PET). Four studies had a low risk of bias, with the majority consistently demonstrating inadequate reporting on randomisation, allocation concealment, blinding, and power calculations. A narrative synthesis approach was assumed due to heterogeneity in study methods, interventions, target cohorts, and quality. Eleven key recommendations are suggested to advance future work in this area.
Russia's Engagement in Conflict and Post-Conflict Settings: Growing Geopolitical Ambitions and “Peace by Force”
Creators: name: Mariani, Bernardo
Publisher: name: University of Edinburgh
Year: 2022
Subjects: Global Transitions
Peace Processes
Russia

description: "In the past decade, Russia has expanded its military, political and diplomatic engagements with conflict-affected states in the post-Soviet space of former USSR nations as well as in Africa, Asia, and the Middle East. With direct military interventions and various forms of hard security engagements in countries such as Ukraine, Kazakhstan, Syria, Libya, Myanmar and the Central African Republic, Russia is intent on projecting power and influence and redefining European and global security. The majority of this paper was researched and written before Russia’s invasion of Ukraine in February 2022, and highlights some of the motivations, policies and practices underpinning Russia’s engagement in conflict-affected countries. It finds that Russia conceptualizes its engagement in conflict and post-conflict settings differently to Western countries, but, to an extent, also from other emergent actors, such as China. The present war in Ukraine highlights Russia’s strategic consideration of the post-Soviet space as a Russian domain that should remain united through security and economic ties and, when necessary, through direct military intervention. In more distant conflict regions, including unstable areas of Africa and the Middle East, Russia’s global political ambitions and its influence on peace and conflict transitions are more opportunistic and tend to exploit the flaws and limitations of Western interventions."
Pragmatic, consensus-based minimum standards and structured interview to guide the selection and development of cancer support group leaders: A protocol paper
Creators: name: Pomery, Amanda
name: Schofield, Penelope
name: Xhilaga, Miranda
name: Gough, Karla
Publisher: name: Swinburne
Year: 2024

description: Introduction: Across the globe, peer support groups have emerged as a community-led approach to accessing support and connecting with others with cancer experiences. Little is known about qualities required to lead a peer support group or how to determine suitability for the role. Organisations providing assistance to cancer support groups and their leaders are currently operating independently, without a standard national framework or published guidelines. This protocol describes the methods that will be used to generate pragmatic consensus-based minimum standards and an accessible structured interview with user manual to guide the selection and development of cancer support group leaders. Methods and analysis: We will: (A) identify and collate peer-reviewed literature that describes qualities of support group leaders through a systematic review; (B) content analyse eligible documents for information relevant to requisite knowledge, skills and attributes of group leaders generally and specifically to cancer support groups; (C) use an online reactive Delphi method with an interdisciplinary panel of experts to produce a clear, suitable, relevant and appropriate structured interview comprising a set of agreed questions with behaviourally anchored rating scales; (D) produce a user manua l to facilitate standard delivery of the structured interview; (E) pilot the structured interview to improve clinical utility; and (F) field test the structured interview to develop a rational scoring model and provide a summary of existing group leader qualities. Ethics and dissemination: The study is approved by the Department Human Ethics Advisory Group of The University of Melbourne. The study is based on voluntary participation and informed written consent, with participants able to withdraw at any time. The results will be disseminated at research conferences and peer review journals. Presentations and free access to the developed structured interview and user manual will be available to cancer agencies.
Peacebuilding in Turbulent Times: Turkey in MENA and Africa
Creators: name: Sofos, Spyros
Publisher: name: University of Edinburgh
Year: 2022
Subjects: Global Transitions
Peace Processes
Turkey

description: Over the past decade, Turkey has become a significant actor in the Middle East, North and sub-Saharan Africa, largely through its development and peacebuilding engagement, and its cultural and commercial penetration within these regions. This involvement has varied in response to both domestic and international developments, allowing Turkey to project itself as a major and ambitious newcomer, among other emerging powers in the development and peacebuilding field. Ankara’s new multidimensional foreign policy framework and its development and peacemaking approach has since undergone a significant transformation as international, regional and domestic developments have prompted the Justice and Development Party (AKP) to respond to challenges and opportunities posed in this field. This report, premised on an extensive review of relevant official documents from the Republic of Turkey’s Ministry of Foreign Affairs, the Presidency of Religious Affairs (DİYANET), the Turkish Cooperation and Coordination Agency (TİKA), analysis of media reports, as well as interviews with policymakers, diplomats and foreign policy, peacebuilding, and development experts assesses the Turkish political leadership and policy community’s understanding of peacebuilding, the contexts and main motivations underlying its conceptualisation and implementation, while outlining potential future developments.
Well-posedness analysis of multicomponent incompressible flow models
Creators: name: Bothe, Dieter
name: Druet, Pierre-Étienne
Publisher: name: Weierstrass Institute
Year: 2020
Subjects: subject: Multicomponent flow
subject: complex fluid
subject: fluid mixture
subject: incompressible fluid
subject: low Mach-number
subject: strong solutions
subject: 35M33
subject: 35Q30
subject: 76N10
subject: 35D35
subject: 35B65
subject: 35B35
subject: 35K57
subject: 35Q35
subject: 35Q79
subject: 76R50
subject: 80A17
subject: 80A32
subject: 92E20

description: In this paper, we extend our study of mass transport in multicomponent isothermal fluids to the incompressible case. For a mixture, incompressibility is defined as the independence of average volume on pressure, and a weighted sum of the partial mass densities of the species stays constant. In this type of models, non solenoidal effects affect the velocity field in the Navier--Stokes equations and, due to different specific volumes of the species, the pressure remains connected to the densities by algebraic formula. By means of a change of variables in the transport problem, we equivalently reformulate the PDE system as to eliminate positivity and incompressibility constraints affecting the density, and prove two type of results: the local-in-time well-posedness in classes of strong solutions, and the global-in-time existence of solutions for initial data sufficiently close to a smooth equilibrium solution.
La gestion des résultats comptables, facteur explicatif de la responsabilité sociale des PME au Cameroun
Creators: name: Cybele Sorielle EWANE
name: Samuel Roland MAKANI
name: Aguynis NINYUM POUOMOGNE
Publisher: name: Zenodo
Year: 2024

description: L’objectif de notre communication est de mettre en exergue les modalités de la gestion des résultats comptables qui favorisent la responsabilité sociale dans des PME au Cameroun. Pour y parvenir, nous avons utilisé les données primaires collectées à l’aide d’un questionnaire administré auprès de 165 PME au Cameroun. Nous avons procédé par la suite à une analyse factorielle et une régression linéaire. Les résultats empiriques confirment que : l’utilisation des accruals ou variables comptables de régularisation (VCR), exerce une influence significative et positive sur la responsabilité sociale via la réduction du taux de gravité des accidents au travail. Par contre, cette même utilisation des accruals n’a aucun effet sur la réduction du nombre de conflits sociaux et la facilité de recrutement des cadres.
Nanostar based platforms for enhanced blood brain barrier crossing
Creators: name: Lopes Rodrigues, Rosalia Cristina
Publisher: name: Imperial College London
Year: 2018

description: The availability of drugs to treat diseases of the central nervous systems is severely restricted by the presence of the blood brain barrier (BBB). The blood-brain barrier prevents the passage of more than 98% of small molecules and 100% of large molecule pharmaceutics. With the rapid progression of neurodegenerative conditions arising with the increase in life expectancy, central nervous system disorders are now the leading cause of death in the United Kingdom, highlighting the urgent need to develop new strategies to effectively cross the blood brain barrier. Nanoscale particles have shown great potential for specifically identifying and binding to the BBB and are currently being investigated for enhanced brain penetration. In this work, the effect of a complex multispiked nanoparticle morphology on BBB penetration is investigated as an alternative to the conventionally used spherical nano-vehicles. Specifically, a platform matrix of plasmonic gold nanoparticles in the shape of gold stars were designed for specific brain targeting and effective transcytosis. The nanostars were synthesised with a highly controllable spectrum of properties including size, surface spikiness and morphology. Successful conformal surface biofunctionalisation with the BBB targeting protein transferrin was achieved for the complex stars and conformational changes due to packing was observed at high concentration of protein. The shape and functional properties of the nanostars was thus preserved after coating. The high surface area of the nanostars enabled superior loading capacity with the transferrin targeting moieties. In transwell transport studies the human brain endothelial cell line hCMEC/D3 showed preferential uptake of AuStrs over spherical nanoparticles. It was found that AuStrs with high aspect ratio, and spiky surface topology constituted the best transcytotic agents. TEM analysis demonstrated that AuStrs penetrate through the cells, not through the tight junctions, thus validating a transcellular transport mechanism. It is demonstrated that the extent of transcytosis and cell uptake can be tuned based on nanostructure geometry and surface biofunctionalization. This thesis provides important insights of the nano-bio interface for the future design of BBB penetrating agents.
In-vitro characterisation of articular cartilage with application to hemiarthroplasty
Creators: name: Imani Masouleh, Maryam
Publisher: name: Imperial College London
Year: 2018

description: Osteoarthritis (OA) is a common form of arthritis that causes joint degradation and affects one in five adults over 45 years of age in the UK. It is characterised by chronic and irreversible degeneration of articular cartilage (AC). Hemiarthroplasty (HA) is a surgical procedure, where the diseased cartilage on one side of the joint is replaced with an implant, while the other side remains intact. The main aim of this study is to analyse the mechanical and frictional response of different shoulder humeral component materials against the natural glenoid. This has been developed as a two-stage process. In a simple geometry HA model, the cartilage coefficient of friction, mechanics and wear have been examined in a pin-on-plate cartilage testing device. In the first stage of this study, friction and wear properties of four different grades of human osteoarthritic AC were measured using pin-on-disc technique against three major types of implant materials used in hemiarthroplasty including Cobalt-Chromium (Co-Cr), Ceramic (Al2O3) and Polycarbonate-urethane (PCU) polymer. Mechanical and frictional properties of the samples were characterised by compression, shear tests and surface roughness measurements using white light interferometry (WLI). Results indicated that at the same stage of OA, the cartilage tribological and mechanical properties deteriorated when using Co-Cr. The second stage of this study focuses on creating a more anatomically realistic model of the hemi-replaced shoulder joint and assesses the cartilage frictional behaviour for both healthy and enzymatically digested AC. A custom-made joint simulator has been built and has been used to investigate the response of shoulder joints under representative loads. The glenoid has been tested against different humeral component materials to understand the friction/wear response of the cartilage. The correlation between enzymatically damaged and healthy cartilage has been investigated. Histological analysis will be performed on the tissue to observe any structural changes due to wear. The results from this study can aid the surgeons to choose the best possible material for hemiarthroplasty according to the disease state of the patient. In the joint simulation of HA, the cartilage coefficient of friction, surface roughness has been studied for both metal and ceramic humeral heads articulating against glenoid cartilage in a pendulum friction simulator. It was demonstrated that: 1) The coefficient of friction increased when metal implants were used compared to ceramic. 2) The COF was higher for enzymatically digested AC compared to healthy samples. 3) Ceramic heads produced lower surface roughness parameters compared to metal implant. The methodologies and findings obtained in this thesis have opened a new line of research and can be adopted for related future studies; additionally, the anatomic pendulum friction natural joint simulation could be used for pre-clinical studies in less invasive procedures.
Expectation and reality in digital publishing: Some Australian perspectives
Creators: name: Martin, Bill
name: Deng, Hepu
name: Tian, Xuemei
Publisher: name: Swinburne
Year: 2024

description: This paper presents a brief summary of the findings of a Web-based survey of the views of Australian publishers, on the potential impact of digital technologies, followed by three case studies conducted between January and April 2007. The survey results indicate that the most influential technologies currently in use in publishing are the Internet and the World Wide Web, with little or any interest being shown in for example, semantic technologies. There is however, widespread realization of the importance of providing enhanced customer value through digital content and delivery channels, with consequent implications for changes to value chains and the emergence of new and transitional business models, which however, are likely to complement rather than replace existing business models. The case studies drawn from a set of eight selected to include a range of value propositions and business models suggest that in Australia publishers are optimistic about the prospects of digitisation but are nonetheless cautious in its uptake and application.
Nonlinearities in the dynamics of reciprocating pipe flow in relation tooscillating water column wave-energy converters
Creators: name: Cui, Lidong
name: Manasseh, Richard
name: Leontini, Justin
name: Tothova, Danica
Publisher: name: Swinburne
Year: 2024

description: As a canonical type of wave energy converter, oscillating water column (OWC) devices have been employed in maritime engineering since the 19th century. In principle, these devices require no moving parts in the water and are thus reliable when exposed to the elements in the real-world. Theoretically, their behaviour is akin to that of reciprocating pipe flow (RPF), in a sense that both OWC and RPF can be described by a same ordinary differential equation (ODE). Like all wave energy converters, OWCs are designed to resonate, and their basic geometry is engineered to resonate using the predictions of linear theory. However, resonance implies large amplitudes, and working OWCs do exhibit large amplitudes that render the behaviour nonlinear, requiring the ODE to be nonlinear, too. In this work, we show that although the nonlinear terms can sometimes only affect the behaviour of RPFs/OWCs quantitatively, these terms can change the behaviour of the oscillations qualitatively in some cases, giving rise to nonlinear behaviour such as hysteresis due to bi-stability. To simplify the discussion, in this work, we consider thin-walled, cylindrical-shaped RPF/OWC devices, although some findings here can be extended to devices of other shapes. When appropriate, the results are related to design aspects of OWCs, specifically whether the nonlinearities can be harnessed for optimisation and control of OWCs.
Changes to Grain Properties due to Breakage in a Sand Assembly using Synchrotron Tomography
Creators: name: Afshar, Tabassom
name: Miri Disfani, Mahdi
name: Narsilio, Guillermo
name: Arulrajah, Arul
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 400502
subject: Civil geotechnical engineering

description: Grain breakage is of paramount importance for understanding the behaviour of granular materials used in various engineering applications, such as pavements, roads, rail tracks, the oil and gas industry, and mineral processing. Changes to grain properties of a uniformly graded sand specimen stemming from breakage during compression were studied with the aid of three-dimensional Synchrotron Radiation-based Micro-Computed Tomography. The fast scanning and high-resolution 4D imaging were utilised to capture images from the interior body of the granular assembly during loading. The fractal distribution of the sand assembly showed that breakage becomes dominant in smaller grains rather than larger ones, where an increase in the amount of newly generated fine fragments leads to high coordination number surrounding the larger grains. More importantly, the results of morphological changes in the particulate assembly revealed that there is a reversal trend in the grain morphology evolution with increasing stress. The sand grains tended to create more spherical fragments with higher aspect ratio whereas by increasing the stress this trend completely shifted.
Ontology-based agent mobility modelling
Creators: name: Baruwal Chhetri, Mohan
name: Price, Rosanne
name: Krishnaswamy, Shonali
name: Loke, Seng W.
Publisher: name: Swinburne
Year: 2024

description: There is increasing recognition of the potential benefits of mobile agent technology for distributed and mobile applications. However, thus far there has been only very limited consideration of the specific requirements for conceptual level modeling of agent mobility to support analysis and design of such applications. Furthermore, the fragmented nature and inconsistent terminology characterizing such research to date complicates the effort to understand and compare the work. An ontology describing the abstract concepts and inter-relationships required to model agent mobility is presented in this paper, intended to serve as the necessary first step to providing conceptual level support for mobile agent applications and as a cogent means of comparing existing work in the area.
PIAVEE - A pedagogy-independent education environment
Creators: name: Krishnaswamy, Shonali
name: Markham, Selby
name: Baruwal Chhetri, Mohan
name: Hurst, John
name: Casey, Des
Publisher: name: Swinburne
Year: 2024

description: A Platform Independent Agent-based Virtual Educational Environment (PIAVEE) is described. PIAVEE is conceptualized as a lightweight, flexible environment that links educational resources through a virtual data base and that is supported by an intelligent delivery system. PIAVEE is implemented through an evolutionary process, whose initial focus is the development of, and access to, the virtual data base. The paper describes the initial implementations, which focus on proof of concept and basic level functionality.
STDs_STIs survey
Creators: name: Papadopoulou
Publisher: name: Zenodo
Year: 2024

description: Supplementary Material 1. SURVEY ON SEX MATTERS, HUMAN REPRODUCTION, SEXUALLY TRANSMITTED DISEASES (STDs), AND CONTRACEPTION 

Journal article: Human Reproduction, Contraception and Sexually Transmitted Infections (STIs): Enhancing College Students’ Awareness, Engagement, Emotions, and Action  

 P. Papadopoulou1*, C. Marouli1, A. Misseyanni1, and M. Koutsokali1  

 1 Deree-The American College of Greece, Department of Science and Mathematics, (GREECE) 

* Author to whom correspondence should be addressed. E-mail: vivipap@acg.edu
Mobile agents as smart virtual counterparts
Creators: name: Baruwal Chhetri, Mohan
name: Loke, Seng W.
name: Krishnaswamy, Shonali
Publisher: name: Swinburne
Year: 2024

description: Smart spaces should not be bound by physical constraints but should transcend them in order to provide enhanced services. One way of overcoming this is by having smart virtual counterparts represent the real world entities in smart spaces. In this paper we propose that mobile agent technology is aptly suited for providing smart virtual counterparts of real-world entities in the virtual world and can be used to enhance the performance of smart spaces. We also present a prototype implementation using the Grasshopper mobile agent toolkit as proof of concept.
Investigating the Citrobacter rodentium NleGs: type III secretion system effector proteins with ubiquitin ligase activity
Creators: name: Sagfors, Agnes Maltide
Publisher: name: Imperial College London
Year: 2018

description: Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) are important agents of infectious diarrhoea in humans. Together with the murine-restricted pathogen Citrobacter rodentium, EPEC and EHEC are attaching and effacing (A/E) pathogens that cause hallmark A/E lesions upon colonisation. Their pathogenesis is underpinned by the injection of effector proteins into the host cytosol via the type III secretion system (T3SS), orchestrating subversion of several eukaryotic pathways. However, the individual roles of many effector proteins are not fully understood. Among these are the NleG family of effectors proteins, which harbour a conserved C-terminus that structurally resembles a eukaryotic E3 ubiquitin ligase domain. C. rodentium has three NleG homologs: NleG1, NleG7 and NleG8, which are translocated into eukaryotic cells via the T3SS as demonstrated herein. Biochemical investigations confirmed that NleG1 and NleG8 exhibit E3 ligase activity, reliant on a conserved proline residue P163/P177 that mediates the interaction between E3 and E2 enzymes. As bacteria lack a ubiquitin system, the NleGs are thought to exploit the host ubiquitin code, a notion supported by our findings that NleG7 and NleG8 cause re-localisation of ubiquitin in cultured cells. Both NleG7 and NleG8 bind ubiquitin by yeast two-hybrid assay and the enzymatic activity of NleG8 is required for cytotoxicity in a yeast model. In vivo, single ∆nleG and double ∆nleG7 ∆nleG8 gene deletions did not affect C. rodentium colonisation of the murine gut, but a triple nleG deletion mutant demonstrated attenuated colonisation, suggesting that NleGs contribute to C. rodentium virulence. Reduced faecal Lipocalin 2, an antimicrobial peptide and marker of gut inflammation, was also observed. Significant efforts to find NleG substrates by yeast two-hybrid and mass spectrometry-based screens using transgenic cell lines are outlined, and this work provides a strong foundation for further studies into NleG biology to give insight into A/E pathogenesis.
Phase Equilibria in Systems Containing Hydrocarbon, Water and Methanol
Creators: name: Lee, Jae Hyuk
Publisher: name: The University of Texas at Austin
Year: 2003
Subjects: Methanol
EOS model

description: The role of methanol as a hydrate inhibitor has risen in industrial interest. It is found that methanol also stimulates production from retrograde gas condensate wells that show extensive productivity reduction because of near wellbore condensate buildup. The phase behavior of systems containing hydrocarbon, water and methanol was reviewed based on past experimental work. The main objective of this report is to review experimental phase behavior data available for hydrocarbon, water and methanol mixtures. The data summarized in Chapters 2, 3 and 4 can be used to verify and improve existing EOS models.
Parametric Study of Relative Permeability Effects on Gas-Condensate Core Floods and Wells
Creators: name: Rai, Rakesh Roshan
Publisher: name: The University of Texas at Austin
Year: 2003
Subjects: Permeability
Dew point

description: A simulation study was done to systematically evaluate the effects of relative permeability parameters on both laboratory corefloods and gas-condensate wells producing below the dew point pressure. A Corey-type relative permeability model was used including the effect of interfacial tension (trapping number or capillary number dependence). The field simulations have been done using five different gas-condensate fluids ranging from lean to rich. The decrease in PI was studied for each case. The simulations of laboratory experiments were carried out to compare and understand the condensate buildup and better understand and interpret these experiments. The University of Texas compositional simulator UTCOMP was used in this study. The coreflood simulations included both condensate accumulation and methanol treatment stages. The three-phase flash capability of UTCOMP was needed to simulate the corefloods in some cases since the water-methanol-hydrocarbon mixtures are liquid-liquid-gas systems under the conditions studied. The sensitivity of the productivity index for both gas and condensate phases differed for all five single-well cases that were simulated and was substantially different for the 8 relative permeability parameters that were studied. The gas PI decreases in direct proportion to the gas relative permeability. The parameters that have the most effect on the gas relative permeability are the gas endpoint, the gas exponent, and the trapping parameter controlling the residual condensate saturation since the gas relative permeability increases as the condensate saturation decreases. Since the gas endpoint decreases as the residual water saturation increases, it also has a direct and significant affect on the gas PI. The gas PI changed on the order of 5 fold with both gas endpoint and residual water saturation. The gas PI changed on the order of 2 fold with both the gas exponent and the oil trapping number parameter. Changes in condensate PI follow similar trends as for gas PI because higher gas rates result in more condensate under surface conditions. A comparison between several high-rate corefloods and the compositional simulations indicated that the residence times were too short in the corefloods for the fluids to achieve local equilibrium. Good history matches were obtained for most of the steady state pressure drops even at high flow rates, but agreement between the simulation results and the experimental data was good for the transient flow period only at the lowest flow rate of 2 cc/hr. The simulations predict that all of the condensate and water (if initially present) is removed from the cores after a few pore volumes of methanol injection. During subsequent gas injection below the dew point pressure, condensate drops out but at a reduced rate until the methanol is stripped out of the core by the flowing gas, and then the pressure drop increases again just as observed in the experiments.
Decision-Making for HIV AIDS Prevention: Altruism and the Moral Norm
Creators: name: Campbell, Gordon
name: Johnson, Lester
Publisher: name: Swinburne
Year: 2024

description: The purpose of this enquiry was to understand how gay men form and maintain their attitudes toward HIV transmission preventative behaviors. Autobiographical life histories of sixteen gay men showed that once they acquired knowledge of preventative behavior they consistently adhered to that behavior. They adhered because of fear of HIV infection and because they held a moral norm that obligated them to behave altruistically (Schwartz, 1977) to protect not only themselves, but also their sex partners, loved ones, and their positive self-evaluation. They saw their HIV negative status, and their adherence, as pre-requisite and enabler for achieving their goals in life. Dick and Basu’s (1994) Framework for Customer Loyalty, a commercial marketing communications theoretical framework, explains development and maintenance of these men’s loyalty (their consistent adherence). This understanding, within a marketing communications framework, will inform development of social marketing communications aiming to increase adherence to behaviors that prevent HIV transmission.
Experiences with software engineering of mobile agent applications
Creators: name: Sutandiyo, Weanna
name: Baruwal Chhetri, Mohan
name: Krishnaswamy, Shonali
name: Loke, Seng Wai
Publisher: name: Swinburne
Year: 2024

description: Mobile agents are a class of software agents that have the ability to move from host to host and are particularly relevant for mobile and distributed applications. The development of several mobile agent implementation environments has necessitated conceptual modelling techniques for mobile agent applications. In this paper, we present mGaia, our extension of the Gaia Agent Oriented Software Engineering (AOSE) methodology to model mobile agent systems.
The formation of young athletes’ specialization on the example of rhythmic gymnastics group exercises
Creators: name: Syvash, Irina
Publisher: name: figshare
Year: 2014
Subjects: Education

description: Purpose: to substantiate the approach to the formation of specializations gymnasts in the initial stages and preliminary basic training. On this basis, to develop the technology selection, orientation and training of athletes in rhythmic gymnastics group exercises. Material: an expert survey of 46 coaches and judges of Ukraine calisthenics different skills training for gymnasts to group exercise. The study involved 50 athletes who are at the initial stages and preliminary basic training. Results: the necessity of forming specialization. Presented educational technology selection, orientation and training gymnasts in group calisthenics exercises. Investigated the components and benefits of the proposed technology. Systematized criteria for selecting gymnasts to group exercise. Conclusions: experimentally proven technology selection, orientation and training of athletes in the group exercise. The main results of the study have been practically implemented in the training process of training young athletes.
Aboriginal health research in the remote Kimberley: An exploration of perceptions, attitudes and concerns of stakeholders
Creators: name: Mc Loughlin, Frieda
name: Hadgraft, Nyssa
name: Atkinson, David
name: Marley, Julia V.
Publisher: name: Swinburne
Year: 2024

description: Background: For decades Indigenous peoples have argued for health research reform claiming methods used and results obtained often reflect the exploitative history of colonisation. In 2006 the Kimberley Aboriginal Health Planning Forum (KAHPF) Research Subcommittee (hereafter, the Subcommittee) was formed to improve research processes in the remote Kimberley region of north Western Australia. This paper explores the major perceptions, attitudes and concerns of stakeholders in the Subcommittee. Methods: Qualitative analysis was carried out on data retrospectively collected from multiple evidentiary sources linked to the Subcommittee i.e. database, documents, interviews, review forms and emails from 1 January 2007 to 31 October 2013. Results: From 1 January 2007 to 30 June 2013 the Subcommittee received 95 proposals, 57 (60%) driven by researchers based outside the region. Local stakeholders (22 from 12 different Kimberley organisations) raised concerns about 36 (38%) projects, 30 (83%) of which were driven by external researchers. Major concerns of local stakeholders were inadequate community consultation and engagement; burden of research on the region; negative impact of research practices; lack of demonstrable community benefit; and power and control of research. Major themes identified by external stakeholders (25 external researchers who completed the review form) were unanticipated difficulties with consultation processes; barriers to travel; perceiving research as a competing priority for health services and time-consuming ethics processes. External stakeholders also identified strategies for improving research practices in the Kimberley: importance of community support in building good relationships; employing local people; flexibility in research approaches; and importance of allocating sufficient time for consultation and data collection. Conclusions: Health research in the Kimberley has improved in recent years, however significant problems remain. Prioritising research addressing genuine local needs is essential in closing the gap in Indigenous life expectancy. The long-term aim is for local health service connected researchers to identify priorities, lead, conduct and participate in the majority of local health research. For this to occur, a more radical move involving reconceptualising the research process is needed. Changes to institutional timeframes and funding processes could improve Indigenous and community-based research.
Influence of extracurricular physical training on motor preparedness of adolescents living in rural areas
Creators: name: Gordіychuk, Viktor
name: Chyzhyk, V.V.
Publisher: name: figshare
Year: 2014
Subjects: Education

description: Purpose: the problem of motor readiness of younger students. Material: in the formative pedagogical experiment involved 32 rural students thirteen years, control group consisted of 223 rural schoolchildren. Results: the trend of deterioration of physical fitness of students in rural schools indicates a problem and the lack of software development and methodological support of physical education of younger students. Developed and put into practice the procedure elective physical training for adolescents in rural schools to improve their physical condition. In the experimental group increased significantly in children dynamic and static strength endurance and speed of movement of the upper limbs. Girls involved in elective classes in physical education, were shrewd they also tend to improve explosive power and flexibility. Conclusions: it was established that the introduction of electives in the process of physical education is one of the most effective means of improving their motor readiness.
Our Sherlockian eyes: the surveillance of vision
Creators: name: Redmond, Sean
name: Sita, Jodi
name: Vincs, Kim
Publisher: name: Swinburne
Year: 2024

description: For this inter-disciplinary article, we undertook a pilot case study that eye-tracked the 'Holmes Saves Mrs. Hudson' sequence from the episode, A Scandal in Belgravia (Sherlock, BBC, 2012). This small-scale empirical study involved a total of 13 participants (3 males and 10 females, mean age was: 27 years), comprised of a mixture of academics and undergraduate students at La Trobe University in Melbourne, Australia. The article examines its findings through a range of threaded frames – neuroscience, forensics, surveillance, haptics, memory, performance-movement, and relationality – and uniquely draws upon the interests of the authors to set the examination in context. The article is both a reading of Sherlock and a dialogue between its authors. We discover that the codes and conventions of Sherlock have a direct impact on where viewers look but we also discover eyes emerging in the periphery of the frame, and we account for these ways of seeing in different ways.
Training-test module in the system of pedagogical control of physical fitness in lower grades
Creators: name: Peleshenko, Igor
Publisher: name: figshare
Year: 2014
Subjects: Education

description: Purpose: to substantiate model characteristics of physical fitness of elementary school students of secondary schools through the introduction of training and test module in the pedagogical control. Material: the study involved 320 boys and 278 girls in grades 1-4 schools in Kharkov number number 57, 112, 166. Results: the level of physical fitness of elementary school students with available motor tests and the results are compared between the experimental data and control classes. Found that the introduction of educational test module in the process of physical education in the experimental classes has enhanced the level of physical fitness. In the experimental classes compared to the control classes, there was an increase of indicators (boys 22.2%, girls 24.6%). Conclusions: the introduction of educational test module in the pedagogical control for primary school pupils, will improve the physical fitness of children in the experimental classes, compared with controls, as well as to determine the averages on basic motor tests that can be used as a model characteristics of physical fitness.
Prof. José Fernandes e Fernandes 1o editor da revista Angiologia e Cirurgia Vascular distinguido pela Society for Vascular Surgery (SVS) as a world leader in vascular surgery
Creators: name: Machado, Rui
Publisher: name: Angiologia e Cirurgia Vascular
Year: 2024

description: Angiologia e Cirurgia Vascular, Vol. 20 No. 2 (2024): June
Blunt traumatic injuries of thoracic aorta, a retrospective study
Creators: name: Baldaia, Leonor
name: F. Antunes, Luís
name: Silva, Miguel
name: Silva, Eduardo
name: Nunes, Celso
name: C. Oliveira, Vânia
name: Silva, Joana
name: Fonseca, Manuel
Publisher: name: Angiologia e Cirurgia Vascular
Year: 2024

description: INTRODUCTION: Blunt thoracic aortic injuries (BTAI) are defined as a tear in the thoracic aorta caused by a high energy blunt trauma with sudden deceleration and increased intravascular pressure. The most common reported mechanism of injury is motor vehicle accidents, and it can be potentially lethal. The purpose of this study was to analyze and report our center’s experience in the treatment of blunt traumatic injuries of thoracic aorta and supra-aortic trunks.

METHODS: A retrospective review of a single center's database was done to identify all patients treated for BTAI, in a four-year period, from January 2018 to December 2021. Follow-up period ranged from three to 24 months. Patients’ demographics, injury mechanism, location and grade of aortic injury, treatment details, timing of intervention, length of hospital stay, follow-up time, and postoperative morbidity and mortality were extracted from patients’ medical records. A descriptive analysis of all the data was performed.

RESULTS AND DISCUSSION: We identified six patients to include in the study. Mean age was 29 years and 83.3% of patients were male. The mechanism of injury was motor vehicle accident for all cases. The most common injury grade was type III (pseudoaneurysm) in five patients (83.3%), and one patient presented with a type IV aortic injury with rupture. All injuries were in the aortic isthmus and all patients were suitable for TEVAR. Mean time to intervention was 17 days. Mean oversizing was 11%. Two patients had coverage of their LSA. No deaths occurred in the hospital or during the follow-up period, and there were no registered vascular procedure-related morbidities.

CONCLUSION: This study reports a level one trauma center experience in management of BTAI. All patients underwent CTA for diagnosis and grading of aortic injury. TEVAR proved to be effective in the treatment of BTAI, with few complications and good outcomes at short and mid-term follow-up, and it should be the first-line treatment for these patients. OSR should be an option when a patient’s injury is not suitable for endovascular approach.
description: Angiologia e Cirurgia Vascular, Vol. 20 No. 2 (2024): June