cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Capra ammon Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Bovidae
Capra
Capra ammon

description: Capra ammon [spec. nov.]
C. cornibus arcuatis, collo subtus barbato, cauda nigra. �
Tryelaphus & Musimon. Gesn. quadr. 155.
Habitat in Sibiria. Gmelin.
Medium quasi inter Capras & Oves.
Animalis hujus historia desideratur.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 70, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Supergravity, $α$-attractors and primordial non-Gaussianity
Creators: name: Bartolo, Nicola
name: Bianco, Domenico Matteo
name: Jimenez, Raul
name: Matarrese, Sabino
name: Verde, Licia
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute in detail how deviations from Einstein gravity at the inflation energy scale could appear as non-Gaussian features in the sky. To illustrate this we use multi-field $α-$attractor models in the framework of supergravity to realise inflation. We find no obvious obstacle for having choices of model's parameters that generate non-Gaussian features of the equilateral and local type at the $\cal O$(1) level in the $f_{\rm NL}$ non-Gaussianity parameter, thus being potentially detectable in future cosmological surveys. This non-Gaussianity has its origin in either the non-canonical kinetic term (which, in turn, is an immediate consequence of assuming an hyperbolic geometry of the moduli space), the interactions of the fields in the potential or the $α-$parameter, or a combination of these three. This opens up the exciting possibility of constraining the law of gravity at energy scales close to the Planck one.
description: matches version published in JCAP; no major changes, conclusions unchanged
Additional file 1: of A theory-based multi-component intervention to increase reactive balance measurement by physiotherapists in three rehabilitation hospitals: an uncontrolled single group study
Creators: name: Sibley, Kathryn
name: Bentley, Danielle
name: Salbach, Nancy
name: Gardner, Paula
name: McGlynn, Mandy
name: OâHoski, Sachi
name: Shaffer, Jennifer
name: Shing, Paula
name: McEwen, Sara
name: Beauchamp, Marla
name: Hossain, Saima
name: Straus, Sharon
name: Jaglal, Susan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Computational Biology

description: Reactive balance measure administration form. (DOC 58 kb)
Violence risk assessment tool implementation to improve identification of potential behavioral events and prevent workplace violence in the emergency department
Creators: name: Kim, Diana
Publisher: name: No Publisher Supplied
Year: 2024

description: Purpose of Project: The objective of this project was to initiate a violence risk screening tool in the Emergency Department triage and determine if implementation of screening tool will improve identification of violent patients on arrival to the Emergency Department.Methodology: The setting was at an urban Emergency Department that is a Level 1 trauma center, STEMI receiving center, primary stroke center and a 470+ bed teaching healthcare facility. Screening tools was completed at triage based on patient behavioral cues. De-identified data collected was behavior presented, interventions, score, date of service, and if provider was contacted. Study outcomes measured whether implementing a violence risk assessment tool improved identification compared to previous method of screening. Results: There was significant improvement in identification of patients who were at moderate/high risk for violence. There was a significant increase in identifying these violent patients after using the Violence Aggression Assessment Checklist tool in triage, t(110) = -9.332, p = <0.001. There was a significant increase in identifying these violent patients after using the VAAC tool in triage, t (110) = -9.332, p = <0.001. The number of violent patients that were identified pre-implementation and post-implementation was compared and found to be significant (2 (1, N = 152) = 48.247, p<0.001). These results support the use of the Violence Aggression Assessment Checklist tool in the early identification of violent patients in triage. Implications for Practice: Early identification helps anticipate potential behavioral events which can be communicated with the care team. Having an early form of communication between healthcare providers and formulating a plan of action when caring for these patients can help prevent future injuries. For violent patients, re-assessments should also be considered in the future. Results will be submitted to Emergency Nurses Association for consideration for publication.
Outbursts, State Transitions, and Periodicities Observed with the RXTE All-Sky Monitor
Creators: name: Levine, Alan M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Results from the All-Sky Monitor (ASM) on the Rossi X-ray Timing Explorer are reviewed. A number of recurrent transient sources have been detected, while only a few previously unreported sources have been discovered. The ASM light curves show a wide variety of phenomena in general, and, in particular, those of transient sources show a wide range of properties. Examples are used to illustrate that the distinction between persistent and transient sources may be very unclear. The results of searches for periodicities in the ASM light curves are summarized, and other astrophysical investigations using ASM light curves are suggested. The latter include investigations of the possible causes of long-term quasiperiodic and chaotic variability, and comparative studies on the basis of the observed variability.
description: 8 pages, 4 figures, in proceedings of the conference "The Active X-ray Sky: Results from BeppoSAX and Rossi-XTE, Rome, Italy, 21-24 October, 1997. Nuclear Physics B Proceedings Supplements
A reflection of pre-hospital imaging on traumatic intra-abdominal haemorrhage
Creators: name: Chaudery, Muzzafer
Publisher: name: Imperial College London
Year: 2016

description: Torso haemorrhage remains one of the leading causes of preventable morbidity and mortality from trauma particularly in the prehospital setting. Early identification of the haemorrhage source is essential in order to improve outcomes and an effective imaging modality may help to establish the diagnosis. This thesis examines how to improve abdominal haemorrhage identification in the prehospital setting in order to achieve rapid haemorrhage control. The current literature is appraised and a national questionnaire distributed to frontline trauma care physicians. For haemorrhage identification research into ultrasound is recommended and for haemorrhage control novel procedures such as Resuscitative endovascular balloon occlusion of the Aorta (REBOA) are valued. FAST (Focused abdominal sonography for trauma) is considered the most appropriate modality for haemorrhage identification in the prehospital setting but it is associated with a steep learning curve. In order to improve training, a face, content and construct validation of a FAST simulator model is undertaken. Furthermore to better understand an ideal performance, an ergonomic analysis of experts’ workspace and force during a FAST scan is conducted. From this, an expert set of metrics is derived of the ideal ultrasound probe position and force for each FAST region. A learning curve study is implemented to assess two randomised groups of novices one trained with the expert metrics and the other trained using a standardised curriculum. The expert metrics group are faster and more accurate at performing a FAST scan than the control. This is also the case in a prospective validity study. REBOA is being investigated as a novel technique for prehospital haemorrhage control. Accurate inflation of the balloon catheter within the correct zone is critical to gain control of bleeding and prevent adverse effects, particularly in the prehospital setting. A feasibility study identifies that ultrasound guidance and balloon insufflation with contrast agent enhances catheter placement within Zone III. Subsequently, two groups of physicians are randomised to perform REBOA with and without ultrasound guidance. The former are faster and more precise than the latter group hence supporting the robustness of the ultrasound imaging technique. Overall this thesis enhances prehospital abdominal haemorrhage identification by improving FAST training and augments haemorrhage control through accurate REBOA placement with the use of ultrasound and contrast agent.
Reduction in patient wait times for stroke symptoms in the emergency department following BEFAST training expansion for non-licensed ancillary staff
Creators: name: Kolomoytsev, Mikhail
Publisher: name: No Publisher Supplied
Year: 2024

description: Purpose of Project: Optimal management for acute stroke is highly dependent upon rapid symptom recognition and administration of time-sensitive treatments. Methodology: This quality improvement project aimed to reduce the wait time in the Emergency Department (ED) for patients who arrived without Emergency Medical Services (EMS) with symptoms suspicious for acute stroke. Non-licensed ancillary staff were trained in the BEFAST acronym for recognition of stroke symptoms to expedite escalation to an appropriate provider. Results: A significant 45% reduction in overall wait time (t(125)=1904.34, p<.001 was achieved for the time period of April 1 – June 30, 2023 (M = 8.1, S.D. = 7.92) compared to April 1 – June 30, 2022 (M = 14.8, S.D. = 13.79) for a total of 126 patients. Furthermore, a 30% reduction in wait time for individuals with a confirmed stroke (t(47)=1.425, p = .08) was achieved between April 1 – June 30, 2022 (M = 12.4, S.D. = 877) and April 1– June 30, 2023 (M = 8.6, S.D. = 9.9) for a total of 49 patients. Most symptoms (95%) identified in patients were components of BEFAST, with the most common symptoms being weakness/numbness/tingling, slurred speech/expressive aphasia, and loss of balance. These results contribute to enhanced clinical practice as time-sensitive treatment becomes a feasible option that is aligned with the American Heart Association stroke treatment goals. Implications for Practice: Expansion of the BEFAST acronym training is warranted in other departments as well as the community to ensure patients experiencing acute stroke symptoms are promptly identified.
Ultrasound assessment of fetal cardiac function and risk of adverse obstetric and neonatal outcomes in term fetuses
Creators: name: Paramasivam, Gowrishankar
Publisher: name: Imperial College London
Year: 2017

description: Aim: To measure fetal cardiac output prior to labour and assess the risk of adverse obstetric and neonatal outcome in singleton pregnancies with appropriately grown for gestational age (AGA) fetuses at term. Methods: This was a prospective observational study conducted at Queen Charlotte’s and Chelsea Hospital, London UK. Fetal cardiac output and fetal cerebroplacental ratio (CPR) was measured within 72 hours before birth in 200 nulliparous women having singleton pregnancies with AGA fetuses. Scan details were not available to the clinicians and delivery was managed per the local protocol and guidelines. Obstetric and neonatal outcomes were obtained from case notes and correlated with the ultrasound findings. Results: Delivery was vaginal in 129 (64.5%) cases and by caesarean section in 71 (35.5%), including 34 (17.0%) for fetal distress and 37 (18.5%) for failure to progress. Fetuses delivered by caesarean section for fetal distress, compared to the remaining fetuses, had a lower median left cardiac output(LCO) (152.3 vs. 191.7 mL/min/kg; p=0.003), higher difference in the median ratio between the right to left cardiac output (RCO to LCO ratio) 1.925 vs. 1.340; p=0.002) and lower CPR (1.222 vs. 1.607; p<0.0001). In screening for emergency caesarean section for fetal distress, for a 10% false positive rate, the detection rate with the RCO to LCO ratio was higher that with the LCO (41% vs. 29%) and with the CPR (41% vs. 27%). Similarly, the positive predictive value for the RCO to LCO ratio (45%) was higher than LCO (37%) and the CPR (35%). Conclusion: In AGA fetuses at term that develop intrapartum distress, there is evidence of prelabour redistribution of the cardiac output. The RCO to LCO ratio is superior to the LCO and CPR in predicting intrapartum fetal distress. Such assessments may be useful in stratifying patients for the intensity of monitoring during labour.
Distal ablation and directly observed medical therapy as potential protocol advancements for renal denervation for hypertension: a study evaluating invasive hemodynamic parameters to predict response to renal denervation
Creators: name: Finegold, Judith
Publisher: name: Imperial College London
Year: 2016

description: Aims: (1) Explore the physiological effect of renal denervation (RDN) (2) Explore the efficacy of distal denervation on blood pressure (BP) reduction in patients undergoing directly observed anti-hypertensive therapy (DOT) to minimise measurement bias (3) Evaluate the 6-month safety of distal denervation Methods: Patients with resistant hypertension were recruited and underwent assessment of drug compliance by assaying urinary drug levels. All subsequent measurements were recorded under DOT. Pre-denervation, office and ambulatory BP were measured, and patients underwent bilateral renal angiography and invasive measurement of aortic and renal arterial pressure and blood flow velocity. RDN was performed using the Symplicity Spyral catheter, denervating in the main renal arteries and each distal branch >3mm diameter. Invasive and non-invasive measurements were repeated 6-months post denervation under DOT. Results: 16 patients underwent denervation (age 63±12 years) with referral office SBP 180±18 mmHg. In total each patient received 22.6±5.0 ablations, 9.3±2.9 ablations in the main trunk and 13.3±4.8 ablations distally. At 6-months follow-up, overall unblinded 24-hour SBP reduction was -5.1±7.5 mmHg (p=0.020), with DBP reduction -3.4±4.9 mmHg (p=0.018). At 6-months follow-up an overall increase in renal blood flow velocity occurred at rest (1.91±3.51cm/s, p=0.04) and under identical sedation states (1.81±3.44 cm/s, p=0.05). Patients with the largest reduction in ambulatory SBP at 6-months had the largest increase in renal blood flow acutely after RDN (R 2=0.60, p<0.001) and the largest decrease in renal resistance (R2=0.56, p<0.001). Quantitative vessel angiography showed no significant change in any main or distal renal artery dimensions at 6-months. Conclusion: This unblinded study of distal RDN showed a significant reduction in ambulatory systolic and diastolic BP with no safety concerns at 6-months. These exploratory results suggest that acute changes in renal hemodynamics may be predictive of blood pressure response at 6-months follow-up.
Ovis Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Bovidae
Ovis

description: Ovis [gen. nov.]
Cornua concava, retrorsum versa, intorta, rugosa.
Dentes Primores inferiores VIII.
Laniarii nulli.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 70, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
ARGOS at the LBT. Binocular laser guided ground layer adaptive optics
Creators: name: Rabien, S.
name: Angel, R.
name: Barl, L.
name: Beckmann, U.
name: Busoni, L.
name: Belli, S.
name: Bonaglia, M.
name: Borelli, J.
name: Brynnel, J.
name: Buschkamp, P.
name: Cardwel, A.
name: Contursi, A.
name: Connot, C.
name: Davies, R.
name: Deysenroth, M.
name: Durney, O.
name: Eisenhauer, F.
name: Elberich, M.
name: Esposito, S.
name: Frye, B.
name: Gaessler, W.
name: Gasho, V.
name: Gemperlein, H.
name: Genzel, R.
name: Georgiev, I. Y.
name: Green, R.
name: Hart, M.
name: Kohlmann, C.
name: Kulas, M.
name: Lefebvre, M.
name: Mazzoni, T.
name: Noenickx, J.
name: Ott, T.
name: de Xivry, G. Orban
name: Peter, D.
name: Puglisi, A.
name: Qin, Y.
name: Quirrenbach, A.
name: Raab, W.
name: Rademacher, M.
name: Rahmer, G.
name: Rix, H. W.
name: Rosensteiner, M.
name: Salinari, P.
name: Schwab, C.
name: Sivitilli, A.
name: Steinmetz, M.
name: Storm, J.
name: Veillet, C.
name: Weigelt, G.
name: Ziegleder, J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Having completed its commissioning phase, the Advanced Rayleigh guided Ground-layer adaptive Optics System (ARGOS) facility is coming online for scientific observations at the Large Binocular Telescope (LBT). With six Rayleigh laser guide stars in two constellations and the corresponding wavefront sensing, ARGOS corrects the ground-layer distortions for both LBT 8.4m eyes with their adaptive secondary mirrors. Under regular observing conditions, this set-up delivers a point spread function (PSF) size reduction by a factor of ~2--3 compared to a seeing-limited operation. With the two LUCI infrared imaging and multi-object spectroscopy instruments receiving the corrected images, observations in the near-infrared can be performed at high spatial and spectral resolution. We discuss the final ARGOS technical set-up and the adaptive optics performance. We show that imaging cases with ground-layer adaptive optics (GLAO) are enhancing several scientific programmes, from cluster colour magnitude diagrams and Milky Way embedded star formation, to nuclei of nearby galaxies or extragalactic lensing fields. In the unique combination of ARGOS with the multi-object near-infrared spectroscopy available in LUCI over a 4x4 arcmin field of view, the first scientific observations have been performed on local and high-z objects. Those high spatial and spectral resolution observations demonstrate the capabilities now at hand with ARGOS at the LBT.
description: 21 pages, 28 figures
The line shapes of the $Z_b(10610)$ and $Z_b(10650)$ in the elastic and inelastic channels revisited
Creators: name: Wang, Q.
name: Baru, V.
name: Filin, A. A.
name: Hanhart, C.
name: Nefediev, A. V.
name: Wynen, J. -L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The most recent experimental data for all measured production and decay channels of the bottomonium-like states $Z_b(10610)$ and $Z_b(10650)$ are analysed simultaneously using solutions of the Lippmann-Schwinger equations which respect constraints from unitarity and analyticity. The interaction potential in the open-bottom channels $B^{(*)}\bar{B}^{*}+\mbox{c.c.}$ contains short-range interactions as well as one-pion exchange. It is found that the long-range interaction does not affect the line shapes as long as only $S$ waves are considered. Meanwhile, the line shapes can be visibly modified once $D$ waves, mediated by the strong tensor forces from the pion exchange potentials, are included. However, in the fit they get balanced largely by a momentum dependent contact term that appears to be needed also to render the results for the line shapes independent of the cut-off. The resulting line shapes are found to be insensitive to various higher-order interactions included to verify stability of the results. Both $Z_b$ states are found to be described by the poles located on the unphysical Riemann sheets in the vicinity of the corresponding thresholds. In particular, the $Z_b(10610)$ state is associated with a virtual state residing just below the $B\bar{B}^{*}/\bar B{B}^{*}$ threshold while the $Z_b(10650)$ state most likely is a shallow state located just above the $B^*\bar{B}^{*}$ threshold.
description: 22 pages, 10 figures
The Linear-Size Evolution of Classical Double Radio Sources
Creators: name: Neeser, Mark J.
name: Eales, Stephen A.
name: Law-Green, J. Duncan
name: Leahy, Patrick
name: Rawlings, Steve
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent investigations of how the median size of extragalactic radio sources change with redshift have produced inconsistent results. Eales compared the radio and optical properties of a bright 3C and faint 6C sample and concluded that $D\propto(1+z)^{-1.1\pm0.5}$ ($Ω_0 = 0$), with $D$ being the median size of the radio sources at a given epoch and z the redshift. Oort, Katgert, and Windhorst, on the other hand, from a comparison of the properties of a number of radio samples, found much stronger evolution, with $D\propto(1+z)^{-3.3 \pm0.5}$. In this paper we attempt to resolve the difference. We have repeated the analysis of Eales using the virtually complete redshift information that now exists for the 6C sample. Confining our analysis to FR2 sources, which we argue is the best-understood class of radio sources and the least likely to be affected by selection effects, we find $D\propto(1+z)^{-1.2\pm0.5}$ ($Ω_0 = 0$) and $D\propto(1+z)^{-1.7\pm0.4}$ ($Ω_0 = 1$). Our complete redshift information allows us to gain insight into our result by plotting a radio luminosity-size (P-D) diagram for the 6C sample. The most obvious difference between the 3C and 6C P-D diagrams is the clump of sources in the 6C diagram at $D\sim 100 kpc, P_{151}\sim 5x10^{27} WHz^{-1}sr^{-1}$. These clump sources have similar sizes to the emission-line regions found around high-redshift radio galaxies, suggesting that the presence of dense line-emitting gas around high-redshift radio galaxies is responsible for the size evolution. We show that this explanation can quantitatively explain the observed size evolution, as long as there is either little X-ray emitting gas around these objects or, if there is, it is distributed in a similar way to the emission-line gas: highly anisotropic and inhomogeneous.
description: compressed and uuencoded postscript file. 33 pages including 5 figures (441951 bytes). Accepted for publication in September ApJ
title:  Le start up cooperative: sei esperienze di innovazione mutualistica
Creators: name: Centro, Achille
name: Loscalzo, Anna
name: Lovens , Anselma
name: Lobello , Elio
name: Cornaglia, Luigi
name: Ciacci  , Rosa
Publisher: name: RomaTrE-Press
Year: 2020

description: Il capitolo è una suddivisione di sei storie di startup cooperative. In questa sessione, vengono raccontati i casi studio di Ecoplanner, scritto da Rosa Ciacci; Meet Project, di Elio Lobello; Vascitour, di Achille Centro; BoschiVivi, scritto da Anselma Lovens; Tatabox, scritto da Anna Loscalzo; e Demoelà, di Luigi Cornaglia. Esperienze che forniscono un panorama ampio, ma estremamente lucido, delle opportunità offerte dalle cooperative che diventano, de facto, degli strumenti rilevanti per la gestione condivisa dei beni comuni.
description: Cooperative bene comune
title: The Effect of X-Ray and Heavy Ions Radiations on Chemotherapy Refractory Tumor Cells
Creators: name: Yu, Zhan
name: Hartel, Carola
name: Pignalosa, Diana
name: Kraft-Weyrather, Wilma
name: Jiang, Guo-Liang
name: Diaz-Carballo, David
name: Durante, Marco
Publisher: name: Frontiers Media S.A.
Year: 2024

description: Purpose: The purpose of this study is to link both numeric and structural chromosomal aberrations to the effectiveness of radiotherapy in chemotherapy refractory tumor cells.

Materials and methods: Neuroblastoma (LAN-1) and 79HF6 glioblastoma cells derived from patients and their chemoresistant sublines were artificially cultured as neurospheres and irradiated by X-rays and heavy ions sources. All the cell lines were irradiated by Carbon-SIS with LET of 100 keV/μm. However, 79HF6 cells and LAN-1 cells were also irradiated by Carbon-UNILAC with LET of 168 keV/μm and Nickel ions with LET of 174 keV/μm, respectively. The effect of radiation on the survival and proliferation of cells was addressed by standard clonogenic assays. In order to analyze cell karyotype standard Giemsa staining, multicolor fluorescence in situ hybridization (mFISH) and multicolor banding (mBAND) techniques were applied.

Results: Relative biological effectiveness values of heavy ion beams relative to X-rays at the D10 values were found between 2.3 and 2.6 with Carbon-SIS and Nickel for LAN-1 and between 2.5 and 3.4 with Carbon-SIS and Carbon-UNILAC for 79HF6 cells. Chemorefractory LAN-1RETO cells were found more radioresistant than untreated LAN-1WT cells. 79HF6RETO glioblastoma cells were found more radiosensitive than cytostatic sensitive cells 79HF6WT. Sphere formation assay showed that LAN-1RETO cells were able to form spheres in serum-free culture, whereas 79HF6 cells could not. Most of 79HF6WT cells revealed a number of 71–90 chromosomes, whereas 79HF6RETO revealed a number of 52–83 chromosomes. The majority of LAN-1WT cells revealed a number of 40–44 chromosomes. mFISH analysis showed some stable aberrations, especially on chromosome 10 as judged by the impossibility to label this region with specific probes. This was corroborated using mBAND analysis.

Conclusion: Heavy ion irradiation was more effective than X-ray in both cytostatic naive cancer and chemoresistant cell lines. LAN-1RETO chemoresistant neuroblastoma cells were found to be more radioresistant than the cytostatic naive cells (LAN-1WT), whereas this effect was not found in 79HF6 cells.
Ovis aries Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Bovidae
Ovis
Ovis aries

description: Ovis aries [spec. nov.]
O. cornibus compressis lunatis. Faun. suec. 43. Syst. nat. 15. n. 1.
Ovis. Gesn. quadr. 138. Aldr. bisulc. 370. Jonst. quadr. t. 22. f. 1. 2. 3. Raj. quadr. 73.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 70, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Change Point Methods on a Sequence of Graphs
Creators: name: Zambon, Daniele
name: Alippi, Cesare
name: Livi, Lorenzo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Given a finite sequence of graphs, e.g., coming from technological, biological, and social networks, the paper proposes a methodology to identify possible changes in stationarity in the stochastic process generating the graphs. In order to cover a large class of applications, we consider the general family of attributed graphs where both topology (number of vertexes and edge configuration) and related attributes are allowed to change also in the stationary case. Novel Change Point Methods (CPMs) are proposed, that (i) map graphs into a vector domain; (ii) apply a suitable statistical test in the vector space; (iii) detect the change --if any-- according to a confidence level and provide an estimate for its time occurrence. Two specific multivariate CPMs have been designed: one that detects shifts in the distribution mean, the other addressing generic changes affecting the distribution. We ground our proposal with theoretical results showing how to relate the inference attained in the numerical vector space to the graph domain, and vice versa. We also show how to extend the methodology for handling multiple change points in the same sequence. Finally, the proposed CPMs have been validated on real data sets coming from epileptic-seizure detection problems and on labeled data sets for graph classification. Results show the effectiveness of what proposed in relevant application scenarios.
The utility of sphingolipid pathway inhibitors in the treatment of aspergillosis
Creators: name: Vinci, Carmelina
Publisher: name: Imperial College London
Year: 2016

description: A. fumigatus is a ubiquitous fungus that causes invasive pulmonary aspergillosis (IPA). IPA is one of the most life-threatening infections in immune compromised patients. Corticosteroids are commonly prescribed as immunosuppressive agents for transplant patients, and IPA mostly occurs in the setting of potent transplant maintaining immune suppressive therapy. Corticosteroid immune suppression represents a major risk factor for IPA, as it inhibits the killing capacity of alveolar macrophages and results in fungal growth that recruits non-sterilizing PMNs to the site of infection that leads to tissue damage. This PhD aimed to characterize effects of the sphingosine-1-phosphate (S1P) pathway inhibitors SKI-II and FTY720 for their utility in attenuating the characteristics of IPA immunopathology, such as inflammation and fungal development. Firstly, it was demonstrated that A. fumigatus-mediated cytokines and chemokines were down regulated in vitro in the presence of inhibitors, and direct sphingosine kinase (SphK) inhibition resulted in a phagocytic defect but not S1P1 receptor antagonism. Inflammatory responses and fungal burden were then evaluated in immunocompetent mice with FTY720, and it was shown that cytokine and chemokine responses were inhibited without compromising fungal clearance. Further to this, FTY720 was evaluated for its efficacy in the hydrocortisone model of aspergillosis. Both pro-inflammatory mediators and fungal burden were reduced, and increased survival was observed. Secondly, the antifungal properties of both SKI-II and FTY720 were investigated. SKI-II was shown to have limited activity with germination kinetics but inhibited hyphal extension, whereas FTY720 was demonstrated to inhibit fungal germination and hyphal growth significantly. Genetic deletions in A. fumigatus of SphK and gprD putative genes were generated, corresponding to mammalian sphingosine kinase 1 and S1P1. Phenotypic examination showed that mutants were sensitive to cell wall stress and had altered germination kinetics, and ∆gprD was less immunogenic. Overall these findings in this thesis indicate the S1P1 inhibitor FTY720 has antifungal activity in vitro against A. fumigatus with therapeutic effects in vivo in the HC model of IPA and could be developed as an antifungal therapeutic.
Assessment of surgical performance
Creators: name: MacKenzie, Colin
Publisher: name: Imperial College London
Year: 2016

description: Surgical patient outcomes are related to technical and non-technical skills of the surgeon. Trauma patient operative and management experience has declined since trainee duty-hour restrictions were mandated in 2003 resulting in less experience in technical surgical skills. The Advanced Surgical Skills for Exposure in Trauma (ASSET) cadaver-based course, teaching vascular exposure and haemorrhage control, was developed to fill this training gap. The aim of this Thesis is to develop surgeon performance metrics and to test surgeons before and after taking the ASSET course to determine whether such training improves performance of peripheral vascular control. The importance of training in surgical vascular control in both civilian and military practice, and a description of current surgical training for trauma are described in Chapter 1. Reviews of existing trauma training courses and surgical performance metrics are provided in Chapters 2 and 3, and show limited testing of training courses and lack of trauma surgical performance metrics. Data collection methods, evaluator training and analysis are described in Chapter 4. Chapter 5 evaluates self-confidence of surgeons performing the vascular control procedures in cadavers compared to the performance evaluated by trained evaluators. Preliminary validation of vascular-control performance metrics and testing of a standardized script with item analysis and inter-rater reliability are discussed in Chapter 6. Testing 40 surgeons performing 3 extremity vascular control procedures before and after training is reported in Chapter 7. ASSET training improves performance, but large performance variability, repeated errors and no improvements were found in some surgeons. Chapter 8 reports how blind video analysis checklist, global rating metrics, error occurrence and recovery show convergent validity with co-located evaluators. Chapter 9 identifies the key findings and implications, innovation of the work described in the Thesis and concludes with the potential impact on military readiness and my personal reflection on what I learnt.
Nurse leader competency development in a behavioral health setting
Creators: name: Dove-Tieku, Stephanie
Publisher: name: No Publisher Supplied
Year: 2024

description: Purpose of the Project : Nurses frequently assume leadership roles by default or experience, often without formal role development. Identifying nurse leader competencies and providing formal nurse leader development is critical to prepare competent leaders to navigate workforce challenges in this evolving healthcare environment. Leadership competency development is inconsistent at the project site. The purpose of this project is to engage front-line nurses in creating a professional development plan to enhance leadership competencies. Methodology : The plan-do-study-act quality improvement process was utilized to implement a formal nurse leader competency development project at a behavioral health hospital. Six front-line nurses with three or more years of nursing experience responded to recruitment efforts to participate in leadership competency development by completing a preprogram assessment, a professional development plan, online leadership competency modules as well as a post-program assessment. An overall program evaluation survey was also administered to collect participant demographic information. Results : All six participants completed the required program activities. Competencies developed from the project site's proprietary behavioral competency model were building networks, communicating effectively, driving engagement, developing talent, managing conflict, and persuades. Results showed a one to three point increase from each participant’s pre assessment score to post assessment score in the behavioral competency they chose for development.Implications for Practice Findings from this initiative indicate that an organizational strategy that prioritizes the development of nurse leader competencies can improve potential nurse leader competency and ensure a pipeline of future nurse leaders within the organization.
Heat flow due to time-delayed feedback
Creators: name: Loos, Sarah A. M.
name: Klapp, Sabine H. L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The thermodynamics of stochastic non-Markovian systems is still widely unexplored. We present an analytical approach for the net steady-state heat flux in nonlinear overdamped systems subject to a continuous feedback force with a discrete time delay. We show that the feedback inevitably leads to a finite heat flow even for vanishingly small delay times. Application to an exemplary (bistable) system reveals that the feedback induces heating as well as cooling regimes and leads to a maximum of the medium entropy production at coherence resonance conditions.
description: 10 pages, 4 figures
Presentation of the Portuguese National Chapter at the CoARA National Chapters Exchange Forum 2024
Creators: name: Béu, Bruno
name: Claro, João
Publisher: name: Zenodo
Year: 2024

description: Slides presented at the CoARA National Chapters Exchange Forum 2024.  A description of the event is available here: https://coara.eu/news/building-a-stronger-network-coara-national-chapters-convene-for-a-first-exchange-forum/.
Additional file 2: of A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments
Creators: name: Vavourakis, Charlotte
name: Adrian-Stefan Andrei
name: Maliheh Mehrshad
name: Rohit Ghai
name: Dimitry Sorokin
name: Muyzer, Gerard
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. Taxonomic fingerprints determined by 16S rRNA gene amplicon sequencing. Figure S2. Genome statistics of the 871 MAGs. Figure S3. Phylogeny of MAGs belonging to “Candidatus Aenigmarchaeota” and “Ca. Nanohaloarchaeota”. Figure S4. Phylogeny of MAGs related to “Candidatus Acetothermia”, candidate division WS1 and “Candidatus Lindowbacteria”. Figure S5. Phylogeny of MAGs related to candidate division KSB3 and “Candidatus Schekmanbacteria”. Figure S6. Multiple sequence alignment of the V-type ATPase subunits K. Figure S7. Multiple sequence alignment of the F-type ATPase subunits c. Figure S8. Maximum likelihood tree of the large subunits of RuBisCo and RubisCo-like proteins. Figure S9. Maximum likelihood tree of the putative rhodopsins. Figure S10. Predicted isoelectric points (pI) profiles of all MAGs from CPR members. Figure S11. Predicted isoelectric points profiles for members of the “Ca. Nealsonbacteria” and “Ca. Vogelbacteria”. Figure S12. Multiple sequence alignment of the dissimilatory cytochrome c nitrite reductases (nrfA/TvNiR, K03385). Figure S13. Overview of the post-binning workflow used for genome recovery. (PDF 6548 kb)
Molecular and nanoparticle-based multimetallic assemblies for sensing applications
Creators: name: Toscani, Anita
Publisher: name: Imperial College London
Year: 2016

description: Chapter 1 introduces the concept of optical sensing and describes the operation of a molecular-base optical sensor along with its characterising parameters. The photophysical properties and the principal sensing mechanisms of transition metal-based optical sensors are herein explained with detailed examples. Chapter 2 describes the past developments in the field of optical detection of sulfur dioxide. Successively, the synthesis and characterisation of a series of 5-coordinate ruthenium complexes and the preliminary studies on their use for the optical detection of sulfur dioxide are described. The reactivity of the complexes towards sulfur dioxide is also investigated. Chapter 3 provides an overview on the chromo-fluorogenic detection of carbon monoxide in air. The synthesis and characterisation of two series of ruthenium and osmium complexes are reported, together with the results of their use as chromo-fluorogenic sensors for carbon monoxide. The mechanism of sensing, as well as the investigation on the sensitivity and selectivity of these sensors, are discussed and compared. In Chapter 4, the new developments on the detection of carbon monoxide in biological systems are described. The optical sensors described in Chapter 3 are herein adapted in order to be employed in aqueous systems. The synthesis, characterisation and the sensing properties of the resulting metal complexes are reported. The cellular viability and preliminary results on the sensing response of two ruthenium complexes internalised in HeLa cells are also reported. Alternatively to the molecular-based systems previously discussed, a sensing system based on the functionalisation of a novel ruthenium probe on the surface of gold nanoparticles is also investigated. Experimental details related to the synthesis, characterisation and photophysical studies of the compounds in Chapters 2 to 4 are detailed in Chapter 5.
Ovis aries subsp. rustica Linnaeus, 1758, subspec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Bovidae
Ovis
Ovis aries
Ovis aries subsp. rustica

description: Ovis aries subsp. rustica [subspec. nov.]
cornuta.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 70, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 1: of A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments
Creators: name: Vavourakis, Charlotte
name: Adrian-Stefan Andrei
name: Maliheh Mehrshad
name: Rohit Ghai
name: Dimitry Sorokin
name: Muyzer, Gerard
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S1. General features of the four sampled soda lakes at time of sampling. Table S2. SILVA classification of the 16S rRNA gene sequences found in all â Ľ1Â kb contigs of five soda sediment metagenomic datasets. Table S3. Enzymes involved in lipopolysaccharide biosynthesis found among different members of the CPR. Table S4. Sub-kingdom classification of candidate SSU rRNA gene fragments found in subsamples of 10 million random forward reads from the five soda sediment metagenomes. Table S5. Top-level taxonomic classification of the 18S rRNA gene fragments found in subsamples of 10 million random forward reads from the five soda sediment metagenomes. Table S6. Description of the metagenomic datasets, NCBI Sequence Read Archive (SRA) accession numbers and general statistics of the assembled contigs. (PDF 740 kb)
Structural and functional characterisation of adhesin and effector proteins from pathogenic fungi
Creators: name: Jones, Rhian
Publisher: name: Imperial College London
Year: 2015

description: This PhD has focussed on characterising two proteins key to fungal infections; the Als adhesins and BEC1054. The Als (agglutinin-like sequence) family of surface adhesins are critical virulence factors from Candida albicans, contributing to biofilm formation and colonisation of a range of tissues in the human host. The broad tissue tropism of Als has been linked to a broadly specific peptide binding cavity (pbc) identified in crystal structures of Als N-terminal domains (NTs). Questions remained regarding the relative roles of the pbc and Als aggregative mechanisms in host cell binding. A series of targeted mutants generated in Als3 were characterised in vitro via NMR and in vivo (collaborator’s work) to delineate these adhesion mechanisms and demonstrate that the pbc alone mediates host binding. It was further demonstrated that sequence differences in the pbcs of Als1 and 3 underlie differences in Als substrate binding specificities. Solution based assays showed that Als3 binds to a wider range of peptide sequences; correlating with a larger pbc and additional interactions with peptides formed in Als-peptide co-crystal structures. We hypothesise that the broader binding specificity of Als3 correlates with the protein’s increased contribution to C. albicans adhesion and virulence in infection. Binding assays provided new insights into the peptide binding mechanism, and a robust system for future development of novel Als inhibitors. Following infection of barley, Blumeria graminis delivers effector proteins such as BEC1054 into the plant to perturb host immunity. The crystal structure of BEC1054 was solved, revealing an RNAse fold that lacks catalytic residues required for hydrolysis. Binding to nucleic acid has been demonstrated, and the binding site localised via mapping of chemical shift perturbations (CSPs) in NMR. Preliminary data have been acquired to test the theory that BEC could associate with ribosomes. Understanding the role of BEC1054 could provide important insights into effector-based modulation of plant immunity, an area that is currently poorly understood.
Manifestation of vibronic dynamics in infrared spectra of Mott insulating fullerides
Creators: name: Matsuda, Yuki
name: Iwahara, Naoya
name: Tanigaki, Katsumi
name: Chibotaru, Liviu F.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The fine structure and temperature evolution of infrared spectra have been intensively used to probe the nature of Jahn-Teller dynamics in correlated materials. At the same time, theoretical framework to adequately extract the information on the complicated vibronic dynamics from infrared spectra is still lacking. In this work, the first-principles theory of the infrared spectra of dynamical Jahn-Teller system is developed and applied to the Mott-insulating Cs$_3$C$_{60}$. With the calculated coupling parameters for Jahn-Teller and infrared active vibrational modes, the manifestation of the dynamical Jahn-Teller effect in infrared spectra is elucidated. In particular, the temperature evolution of the infrared line shape is explained. The transformation of the latter into Fano resonance type in metallic fulleride is discussed on the basis of obtained results.
description: 10 pages
Characterisation of mineralised tissues with raman spectroscopy
Creators: name: You, Amanda
Publisher: name: Imperial College London
Year: 2016

description: Raman spectroscopy imaging presents a sensitive and versatile method to collect biochemical information from biomineralised tissues. The goal of this thesis was to comprehensively investigate biomineralised tissues by developing chemometrics analysis methods. Raman spectroscopy imaging was utilised to compare pathological and physiological calcifications of various biomineralised tissues. The relationship between atherosclerosis and aging on aortic medial and intimal/plaque calcification was interrogated. Cross-sectional concentration profiles of biochemical components were characterised using vertex component analysis (VCA). Significant increases were found in apatite and lipids not only in the atherosclerotic plaque but also in the directly underlying aortic media, where increased whitlockite was also observed. This study revealed a new correlation between atherosclerosis and medial calcification. An investigation into alterations due to bisphosphonate treatment in osteoporotic trabecular bone was done. Results on the composition of mineral and collagen crosslinks suggest that long term bisphosphonate treatment might lead to abnormal bone tissue, which may shed light on the reason for the association with atypical fractures. Healing capacities of different growth plate zones were compared in an organotypic embryonic chick femur model. Immunohistochemistry showed that defects introduced to the resting and proliferative zones demonstrated superior healing to pre-hypertrophic and hypertrophic zones, which show perichondrial-like tissue in the defect site. A method to spatially quantify collagen crosslinks was developed using time-of-flight secondary ion mass spectrometry (ToF-SIMS) mapping. Neonatal rat femurs were mapped, followed by partial least squares-discriminant analysis (PLS-DA). Presence of putative ionic fragments in the growth plate and epiphyseal tissue was observed. These results suggest ToF-SIMS could be a useful technique to identify collagen crosslink molecules in bioengineered systems. Various tissues were successfully characterised using chemometrics methods that were developed throughout the thesis. These methods are easily transferable for future studies of other native and bioengineered tissues or clinical diagnosis using Raman spectroscopy probes.