cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Generalized Pole Inflation: Hilltop, Natural, and Chaotic Inflationary Attractors
Creators: name: Terada, Takahiro
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A reformulation of inflationary model analyses appeared recently, in which inflationary observables are determined by the structure of a pole in the inflaton kinetic term rather than the shape of the inflaton potential. We comprehensively study this framework with an arbitrary order of the pole taking into account possible additional poles in the kinetic term or in the potential. Depending on the setup, the canonical potential becomes the form of hilltop or plateau models, variants of natural inflation, power-law inflation, or monomial/polynomial chaotic inflation. We demonstrate attractor behaviors of these models and compute corrections from the additional poles to the inflationary observables.
description: 22 pages, 5 figures; v3 published version (minor revision) + additional materials (Figures 1, 4 and Table 1). A one-minute introductory movie is available at https://youtu.be/pLod18Z0EVs
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (105 b)]
Creators: name: Airoldus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1189
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Airoldus und seine genannten Brüder, Söhne des verstorbenen Janonus aus Casalbuttano, versprechen, bei den getroffenen Vereinbarungen zu bleiben, ernennen Wilielmus Benadus zu ihrem Bürgen und geben Güter, die sie in Casalbuttano besitzen, als Pfand.
The Creative Merge: At the Intersection of Creativity and Capitalism in a UNESCO City of Literature
Creators: name: Hampton, Lisl
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The City of Literature program within UNESCO’s Creative Cities Network operates within a framework of creativity, capitalism (including tourism), nation, heritage, and power. My task here is to understand how the breadth of the term creativity is used and understood across different registers within the program. I examine the history of the UNESCO Creative Cities Network and its broader context of creative tourism. My analysis is based in part on an examination of cultural policies, interviews I conducted with people affiliated with Cities of Literature, and an analysis of the language of documentation that has come out of the Creative Cities Network. I also turn to some recent academic work on creative tourism and on cities to situate the Creative Cities Network in a scholarly context. Finally, I discuss the creativity of reading as understood through reception studies and ethnographic studies of readers and reading.
Past and present of the definition and operationalization of the Broad Autism Phenotype: a scoping review
Creators: name: Godoy-Giménez, Marta
name: González-Rodríguez, Antonio
name: García-Pérez, Ángel
name: Estévez, Ángeles
name: Cañadas, Fernando
name: Sayans-Jiménez, Pablo
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: BAP in general population
subject: Broad Autism Phenotype
subject: Genetic liability
subject: Non-clinical autist traits
subject: Parents of ASD children
subject: Scoping review
subject: Siblings of ASD children
subject: Subthreshold autist traits

description: Scoping review protocol for updating the broad autism phenotype (BAP) theoretical and operational definition.
Pilotstudie zur Evaluierung eines Impfstoffes mit Salmonella typhi Ty21a als Träger für rekombinante Urease von Helicobacter pylori
Creators: name: Palme, Oliver
Publisher: name: Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
Year: 2004
Subjects: subject: Helicobacter pylori
subject: Impfstoff
subject: zelluläre Immunität
subject: Salmonella typhi
subject: Vaccine
subject: Cellular immune responses
subject: 610 Medizin
subject: 33 Medizin

description: Das Gen für die Expression von Helicobacter pylori Urease wurde in das Genom von Salmonella typhi Ty21a (Typhoral() integriert. Der resultierende Stamm erhielt die Bezeichnung Salmonella typhi Ty21a(pDB1). Neun gesunden Probanden wurde Salmonella typhi Ty21a(pDB1) verabreicht. In der Kontrollgruppe erhielten drei gesunde Probanden Salmonella typhi Ty21a. Schwerwiegende Nebenwirkungen wurden bei keinem der Probanden beobachtet. Zehn von 12 Probanden zeigten eine humorale Immunantwort gegen Antigene von Salmonella typhi, nachgewiesen über die Detektion spezifischer Antikörper produzierender Zellen, aber bei nur zwei Probanden ließ sich eine Serokonversion nachweisen. Eine zelluläre Immunantwort gegen das H-Antigen von Salmonella typhi konnte bei insgesamt fünf Probanden nachgewiesen werden. Insgesamt sechs Probanden zeigten eine zelluläre Immunantwort gegen Urease von Helicobacter pylori in zumindest einem von drei der zur Anwendung gebrachten Testsysteme (Proliferation, T-cell-Elispot, IFN-gamma Elisa). Eine humorale Immunantwort gegen Urease von Helicobacter pylori konnte bei keinem der Probanden nachgewiesen werden. Ty21a(pDB1) ist somit ein geeigneter Prototyp zur Optimierung einer Salmonella basierte Impfung zur Induktion einer zellulären Immunantwort, die zu einer protektiven Immunität gegenüber Helicobacter pylori führen könnte.
description: Helicobacter pylori urease was expressed in the common live typhoid vaccine Salmonella typhi Ty21a (Typhoral() yielding Salmonella typhi Ty21a(pDB1). Nine volunteers received Salmonella typhi Ty21a(pDB1) and three control volunteers received Salmonella typhi Ty21a. No serious adverse effects were observed in any of the volunteers. Ten out of 12 volunteers developed humoral immune responses to the Salmonella carrier as detected by antigen-specific antibody-secreting cells but only two volunteers seroconverted. A total of five volunteers showed cellular responses to the carrier. Six out of nine volunteers that had received Salmonella typhi Ty21a(pDB1) showed a T-cell response to Helicobacter urease in at least one of the three assays for detection of cellular response (Proliferation, T-cell-Elispot, IFN-gamma Elisa). No volunteer had detectable humoral responses to urease. Salmonella typhi Ty21a(pDB1) is a suitable prototype to optimize Salmonella-based vaccination for efficient cellular responses that could mediate protective immunity against Helicobacter.
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
Creators: name: Hagemann, Sven
name: Misiak, Danny
name: Bell, Jessica L.
name: Fuchs, Tommy
name: Lederer, Marcell I.
name: Bley, Nadine
name: Hämmerle, Monika
name: Ghazy, Ehab Mohamed Elbassiony
name: Sippl, Wolfgang
name: Schulte, Johannes Hubertus
name: Hüttelmaier, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strategies. In neuroblastoma, chromosomal gains at chromosome 17q, including IGF2BP1, and MYCN amplification at chromosome 2p are associated with adverse outcome. Recent, pre-clinical evidence indicates the feasibility of direct and indirect targeting of IGF2BP1 and MYCN in cancer treatment. Methods: Candidate oncogenes on 17q were identified by profiling the transcriptomic/genomic landscape of 100 human neuroblastoma samples and public gene essentiality data. Molecular mechanisms and gene expression profiles underlying the oncogenic and therapeutic target potential of the 17q oncogene IGF2BP1 and its cross-talk with MYCN were characterized and validated in human neuroblastoma cells, xenografts and PDX as well as novel IGF2BP1/MYCN transgene mouse models. Results: We reveal a novel, druggable feedforward loop of IGF2BP1 (17q) and MYCN (2p) in high-risk neuroblastoma. This promotes 2p/17q chromosomal gains and unleashes an oncogene storm resulting in fostered expression of 17q oncogenes like BIRC5 (survivin). Conditional, sympatho-adrenal transgene expression of IGF2BP1 induces neuroblastoma at a 100% incidence. IGF2BP1-driven malignancies are reminiscent to human high-risk neuroblastoma, including 2p/17q-syntenic chromosomal gains and upregulation of Mycn, Birc5, as well as key neuroblastoma circuit factors like Phox2b. Co-expression of IGF2BP1/MYCN reduces disease latency and survival probability by fostering oncogene expression. Combined inhibition of IGF2BP1 by BTYNB, MYCN by BRD inhibitors or BIRC5 by YM-155 is beneficial in vitro and, for BTYNB, also. Conclusion: We reveal a novel, druggable neuroblastoma oncogene circuit settling on strong, transcriptional/post-transcriptional synergy of MYCN and IGF2BP1. MYCN/IGF2BP1 feedforward regulation promotes an oncogene storm harboring high therapeutic potential for combined, targeted inhibition of IGF2BP1, MYCN expression and MYCN/IGF2BP1-effectors like BIRC5.
The health impact of caring for grandchildren on grandparent caregivers: a longitudinal study in Taiwan
Creators: name: Ku, Li-Jung Elizabeth
Publisher: name: University of North Carolina at Chapel Hill
Year: 2011

description: This dissertation seeks to determine the impact of caring for grandchildren on the health and health care utilization of Chinese grandparent caregivers. While the current literature on grandparent caregiving has largely shown negative health impact, most of these studies were based in the U.S. and thus grandparents in other countries and cultures have been under-represented. Using four waves of the Survey of Health and Living Status of the Elderly in Taiwan, this longitudinal study not only contributes to cross-cultural comparisons but also addresses methodological issues in the current literature. Panel data analyses are used to estimate the effect of caregiving while controlling for caregiver selection using both fixed effects and instrumental variables. Results show health improvement among grandparent caregivers in measures of self-rated health, mobility limitations, and depressive symptoms. No significant difference is found in health care utilization by grandparent caregiving status, except that caregivers in skipped-generation households or those who have continued to provide care for more than three years are more likely to report having unmet health needs. The overall findings support our hypothesis that caring for grandchildren can be beneficial for the health of grandparents in the Chinese cultural context.
Effective Viscous Damping Enables Morphological Computation in Legged Locomotion
Creators: name: Mo, An
name: Izzi, Fabio
name: Haeufle, Daniel F. B.
name: Badri-Spröwitz, Alexander
Publisher: name: arXiv
Year: 2020
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Muscle models and animal observations suggest that physical damping is beneficial for stabilization. Still, only a few implementations of mechanical damping exist in compliant robotic legged locomotion. It remains unclear how physical damping can be exploited for locomotion tasks, while its advantages as sensor-free, adaptive force- and negative work-producing actuators are promising. In a simplified numerical leg model, we studied the energy dissipation from viscous and Coulomb damping during vertical drops with ground-level perturbations. A parallel spring-damper is engaged between touch-down and mid-stance, and its damper auto-disengages during mid-stance and takeoff. Our simulations indicate that an adjustable and viscous damper is desired. In hardware we explored effective viscous damping and adjustability and quantified the dissipated energy. We tested two mechanical, leg-mounted damping mechanisms; a commercial hydraulic damper, and a custom-made pneumatic damper. The pneumatic damper exploits a rolling diaphragm with an adjustable orifice, minimizing Coulomb damping effects while permitting adjustable resistance. Experimental results show that the leg-mounted, hydraulic damper exhibits the most effective viscous damping. Adjusting the orifice setting did not result in substantial changes of dissipated energy per drop, unlike adjusting damping parameters in the numerical model. Consequently, we also emphasize the importance of characterizing physical dampers during real legged impacts to evaluate their effectiveness for compliant legged locomotion.
A counterexample to Thiagarajan's conjecture on regular event structures
Creators: name: Chalopin, Jérémie
name: Chepoi, Victor
Publisher: name: arXiv
Year: 2016
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: Discrete Mathematics (cs.DM)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We provide a counterexample to a conjecture by Thiagarajan (1996 and 2002) that regular event structures correspond exactly to event structures obtained as unfoldings of finite 1-safe Petri nets. The same counterexample is used to disprove a closely related conjecture by Badouel, Darondeau, and Raoult (1999) that domains of regular event structures with bounded $\natural$-cliques are recognizable by finite trace automata. Event structures, trace automata, and Petri nets are fundamental models in concurrency theory. There exist nice interpretations of these structures as combinatorial and geometric objects. Namely, from a graph theoretical point of view, the domains of prime event structures correspond exactly to median graphs; from a geometric point of view, these domains are in bijection with CAT(0) cube complexes. A necessary condition for both conjectures to be true is that domains of regular event structures (with bounded $\natural$-cliques) admit a regular nice labeling. To disprove these conjectures, we describe a regular event domain (with bounded $\natural$-cliques) that does not admit a regular nice labeling. Our counterexample is derived from an example by Wise (1996 and 2007) of a nonpositively curved square complex whose universal cover is a CAT(0) square complex containing a particular plane with an aperiodic tiling. We prove that other counterexamples to Thiagarajan's conjecture arise from aperiodic 4-way deterministic tile sets of Kari and Papasoglu (1999) and Lukkarila (2009). On the positive side, using breakthrough results by Agol (2013) and Haglund and Wise (2008, 2012) from geometric group theory, we prove that Thiagarajan's conjecture is true for regular event structures whose domains occur as principal filters of hyperbolic CAT(0) cube complexes which are universal covers of finite nonpositively curved cube complexes.
A Novel Biomechanical Model Assessing Orthodontic, Continuous Archwire Activation in Incognito Lingual Braces
Creators: name: Canales, Christopher H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The purpose of this research is to develop a virtual, orthodontic, continuous archwire model for assessing a lingual bracket system. A digital model of a maxilla, periodontal ligament, and dentition was constructed from human computed tomography data. Virtual lingual and facial brackets were placed on the maxillary left central incisor through first premolar. An intrusive tooth movement was utilized to test the model and compare labial and lingual biomechanics. The ANSYS 13.0 birth-death function simulated force interaction between the wire and brackets. The goal of placing labial and lingual bracket-wire systems on accurate anatomy including multiple teeth was achieved. Material property definitions had an effect on a finite element model. The birth-death computer technique simulated the clinical effects of placing an archwire in brackets and allowing forces to be transferred from the bracket-wire system to the surrounding dental structures. The lingual appliance has different biomechanical effects than the labial appliance.
Predictivity lost, predictivity regained: a Miltonian cosmic censorship conjecture
Creators: name: Emparan, Roberto
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Cosmic censorship is known to fail in some well-controlled phenomena, calling into question the predictive power of General Relativity and opening up the possibility of observing Planck-scale physics. We propose that the cosmic censorship conjecture can be amended so that its spirit prevails. Naked singularities that, classically, have zero mass are allowed. Physically, these are Planck-sized `black holes', which evaporate in a few Planck times. General Relativity fails only for a tiny interval in time, to then quickly regain control in a Miltonian evolution that returns us to the predictive paradise of Einstein's equations. If this refinement of the conjecture is correct, then, even though Nature does allow to expose breakdowns in the smooth fabric of spacetime, it limits them to a mostly harmless minimum.
description: 6 pages. Essay for the Gravity Research Foundation 2020 Awards
The interplay between dopamine genes and diet
Creators: name: Hartmann, Hendrik
name: Janssen, Lieneke
name: Horstmann, Annette
name: Rausch, Franziska
Publisher: name: Open Science Framework
Year: 2022

description: The neurotransmitter dopamine plays a central role in several cognitive domains such as motivation, reward-processing, reinforcement learning, decision-making and executive functions including working memory and attention (Arnsten, Wang, & Paspalas, 2012; Logue & Gould, 2013; Rogers, 2011; Schultz, 2002; Volkow, Wise, & Baler, 2017). Results of our recent studies point towards prominent alterations in these domains in overweight and obesity and suggest the existence of a non-linear relationship between markers of obesity and central dopamine tone (Horstmann, Fenske, & Hankir, 2015). Dopamine tone in the brain depends on both genetic and environmental factors. Genetic differences in important genes within the dopaminergic synapse, i.e. COMT (important for dopamine degradation) and dopamine receptor D2 (A1 allele of Taq1A), lead to altered dopamine signaling and can therefore contribute to higher vulnerability for diet-induced obesity (Annerbrink et al., 2008; Epstein et al., 2007). One important environmental factor that is hypothesized to affect dopamine transmission in obesity is an unhealthy diet. Accumulating evidence from animal research suggests that observed differences in dopamine signaling in obesity may be induced by diet rather than obesity (Geiger et al., 2009; Narayanaswami, Thompson, Cassis, Bardo, & Dwoskin, 2013; van de Giessen et al., 2013; Vucetic, Carlin, Totoki, & Reyes, 2012). However, the evidence for diet-induced alterations in dopamine signal transmission and their effects on dopamine-mediated cognitive processes in humans is scarce. In the proposed study, we aim to address the effect of diet high in fat and sugar on dopamine signal transmission in the brain and on dopamine-mediated cognitive performance.
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
Creators: name: Kendzia, Sandra
name: Franke, Susanne Lieselotte
name: Kröhler, Tarek
name: Golob-Schwarzl, Nicole
name: Schweiger, Caroline
name: Toeglhofer, Anna M.
name: Skofler, Christina
name: Uranitsch, Stefan
name: El-Heliebi, Amin
name: Fuchs, Julia
name: Punschart, Andreas
name: Stiegler, Philipp
name: Keil, Marlen
name: Hoffmann, Jens
name: Henderson, David
name: Lehrach, Hans
name: Yaspo, Marie-Laure
name: Reinhard, Christoph
name: Schäfer, Reinhold
name: Keilholz, Ulrich
name: Regenbrecht, Christian René Alexander
name: Schicho, Rudolf
name: Fickert, Peter
name: Lax, Sigurd F.
name: Erdmann, Frank
name: Schulz, Marcel Holger
name: Kiemer, Alexandra Kathrin
name: Haybäck, Johannes
name: Keßler, Sonja
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 615

description: Aim: Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vivo approaches. Methods: Gene expression data from a well-characterized cohort and publicly available cross-linking immunoprecipitation sequencing (CLIP-Seq) data were collected. Resistance to chemotherapeutics was assessed in patient-derived xenografts (PDXs) and patient-derived organoids (PDOs). Functional studies were performed in 2D and 3D cell culture models, including proliferation, spheroid growth, and mitochondrial respiration analyses. Results: We identified IGF2BP2 as the most abundant IGF2BP in primary and metastastatic CRC, correlating with tumor stage in patient samples and tumor growth in PDXs. IGF2BP2 expression in primary tumor tissue was significantly associated with resistance to selumetinib, gefitinib, and regorafenib in PDOs and to 5-fluorouracil and oxaliplatin in PDX in vivo. IGF2BP2 knockout (KO) HCT116 cells were more susceptible to regorafenib in 2D and to oxaliplatin, selumitinib, and nintedanib in 3D cell culture. Further, a bioinformatic analysis using CLIP data suggested stabilization of target transcripts in primary and metastatic tumors. Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) revealed a decreased basal OCR and an increase in glycolytic ATP production rate in IGF2BP2 KO. In addition, real-time reverse transcriptase polymerase chain reaction (qPCR) analysis confirmed decreased expression of genes of the respiratory chain complex I, complex IV, and the outer mitochondrial membrane in IGF2BP2 KO cells. Conclusions: IGF2BP2 correlates with CRC tumor growth in vivo and promotes chemoresistance by altering mitochondrial respiratory chain metabolism. As a druggable target, IGF2BP2 could be used in future CRC therapy to overcome CRC chemoresistance.
FootTile: a Rugged Foot Sensor for Force and Center of Pressure Sensing in Soft Terrain
Creators: name: Ruppert, Felix
name: Badri-Spröwitz, Alexander
Publisher: name: arXiv
Year: 2020
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: In this paper we present FootTile, a foot sensor for reaction force and center of pressure sensing in challenging terrain. We compare our sensor design to standard biomechanical devices, force plates and pressure plates. We show that FootTile can accurately estimate force and pressure distribution during legged locomotion. FootTile weighs 0.9g, has a sampling rate of 330Hz, a footprint of 10 by 10mm and can easily be adapted in sensor range to the required load case. In three experiments we validate: first the performance of the individual sensor, second an array of FootTiles for center of pressure sensing and third the ground reaction force estimation during locomotion in granular substrate. We then go on to show the accurate sensing capabilities of the waterproof sensor in liquid mud, as a showcase for real world rough terrain use.
Electromagnetic Potential in Pre-Metric Electrodynamics: Causal Structure, Propagators and Quantization
Creators: name: Pfeifer, Christian
name: Siemssen, Daniel
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Physics (math-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences
subject: 35Q60, 70S15, 78A25, 81T20

description: An axiomatic approach to electrodynamics reveals that Maxwell electrodynamics is just one instance of a variety of theories for which the name electrodynamics is justified. They all have in common that their fundamental input are Maxwell's equations $\textrm{d} F = 0$ (or $F = \textrm{d} A$) and $\textrm{d} H = J$ and a constitutive law $H = # F$ which relates the field strength two-form $F$ and the excitation two-form $H$. A local and linear constitutive law defines what is called local and linear pre-metric electrodynamics whose best known application are the effective description of electrodynamics inside media including, e.g., birefringence. We analyze the classical theory of the electromagnetic potential $A$ before we use methods familiar from mathematical quantum field theory in curved spacetimes to quantize it in a locally covariant way. Our analysis of the classical theory contains the derivation of retarded and advanced propagators, the analysis of the causal structure on the basis of the constitutive law (instead of a metric) and a discussion of the classical phase space. This classical analysis sets the stage for the construction of the quantum field algebra and quantum states. Here one sees, among other things, that a microlocal spectrum condition can be formulated in this more general setting.
description: 34 pages, references added, update to published version, title updated to published version
The epistemology of science: acceptance, explanation, and realism
Creators: name: Dellsén, Finnur
Publisher: name: University of North Carolina at Chapel Hill
Year: 2014

description: Natural science tells a story about what the world is like. But what kind of story is this supposed to be? On a popular (realist) view, this story is meant to provide the best possible explanations of the aspects of the world with which we are all acquainted. A realist also thinks that the story should in some sense provide explanations that are probable in light of our evidence, and that these explanations ought to fit together into a coherent whole. These requirements turn out to be surprisingly hard to satisfy given the received view of how scientific theories are evaluated. However, I argue that if scientific theories are evaluated comparatively rather than absolutely for explanatory purposes -- optimifically rather than satisficingly -- then we can provide a fully realist view of the connections between explanation, probability, and coherence. It is one thing to say what science's story of the world ought ideally be like, it is another to say that the story as it is actually being told lives up to this ideal. Do we have good reasons to believe that the picture as it is currently being presented to us is true, at least for the most part? Yes, answer realists, as long as our theories are empirically successful. Anti-realists respond that success is a poor guide to truth, appealing to the rather depressing history of successful theories that turned out to be false. Although I count myself among realists, I argue that realists have done themselves a disservice by focusing too much on empirical success in arguing for the correctness of the current scientific world-view. Instead I argue that one of the major reasons why currently accepted theories should (typically) be taken as true concerns the fact that they enjoy a certain kind of privileged status within scientific communities.
Complex length of short curves and Minimal Fibration in hyperbolic $3$-Manifolds fibering over the circle
Creators: name: Huang, Zheng
name: Wang, Biao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: We investigate the maximal solid tubes around short simple geodesics in hyperbolic three-manifolds and how complex length of curves relate to closed, incompressible, least area minimal surfaces. As applications, we prove, there are some closed hyperbolic three-manifolds fibering over the circle which are not foliated by closed incompressible minimal surfaces diffeomorphic to the fiber. We also show, the existence of quasi-Fuchsian manifolds containing arbitrarily many embedded closed incompressible minimal surfaces. Our strategy is to prove main theorems under natural geometric conditions on the complex length of closed curves on a fibered hyperbolic three-manifold, then we find explicit examples where these conditions are satisfied via computer programs.
description: final version, to appear at the Proceeding of the London Math. Soc
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (103)]
Creators: name: Airoldus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1188
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Airoldus, Sohn des verstorbenen Ianonus aus Casalbuttano, belehnt mit dem Einverständnis seiner Brüder den Johannes Bellus de Guarnerio, wohnhaft nahe St. Agathe de Burgo in Cremona, mit Gütern in Casalbuttano, in Braida Tempestata.
MPEC 2023-Q50 : 2023 QH1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 QH1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Entropy production and entropic attractors in black hole fusion and fission
Creators: name: Andrade, Tomas
name: Emparan, Roberto
name: Jansen, Aron
name: Licht, David
name: Luna, Raimon
name: Suzuki, Ryotaku
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study how black hole entropy is generated and the role it plays in several highly dynamical processes: the decay of unstable black strings and ultraspinning black holes; the fusion of two rotating black holes; and the subsequent fission of the merged system into two black holes that fly apart (which can occur in dimension $D\geq 6$, with a mild violation of cosmic censorship). Our approach uses the effective theory of black holes at $D\to\infty$, but we expect our main conclusions to hold at finite $D$. Black hole fusion is highly irreversible, while fission, which follows the pattern of the decay of black strings, generates comparatively less entropy. In $2\to 1\to 2$ black hole collisions an intermediate, quasi-thermalized state forms that then fissions. This intermediate state erases much of the memory of the initial states and acts as an attractor funneling the evolution of the collision towards a small subset of outgoing parameters, which is narrower the closer the total angular momentum is to the critical value for fission. Entropy maximization provides a very good guide for predicting the final outgoing states. Along our study, we clarify how entropy production and irreversibility appear in the large $D$ effective theory. We also extend the study of the stability of new black hole phases (black bars and dumbbells). Finally, we discuss entropy production through charge diffusion in collisions of charged black holes.
description: 40 pages, 13 figures. v2: small improvements and minor corrections to the text, figures, and references
DOLPHIn - Dictionary Learning for Phase Retrieval
Creators: name: Tillmann, Andreas M.
name: Eldar, Yonina C.
name: Mairal, Julien
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optimization and Control (math.OC)
subject: Information Theory (cs.IT)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We propose a new algorithm to learn a dictionary for reconstructing and sparsely encoding signals from measurements without phase. Specifically, we consider the task of estimating a two-dimensional image from squared-magnitude measurements of a complex-valued linear transformation of the original image. Several recent phase retrieval algorithms exploit underlying sparsity of the unknown signal in order to improve recovery performance. In this work, we consider such a sparse signal prior in the context of phase retrieval, when the sparsifying dictionary is not known in advance. Our algorithm jointly reconstructs the unknown signal - possibly corrupted by noise - and learns a dictionary such that each patch of the estimated image can be sparsely represented. Numerical experiments demonstrate that our approach can obtain significantly better reconstructions for phase retrieval problems with noise than methods that cannot exploit such "hidden" sparsity. Moreover, on the theoretical side, we provide a convergence result for our method.
Molecular dissection of the mycobacterial ClpP1P2 complex
Creators: name: Nagpal, Jyotsna
Publisher: name: La Trobe
Year: 2023

description: Restrictions: Thesis embargoed indefinitly.

Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Biochemistry and Genetics, School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora.
Raman spectroscopy: a tool for molecular fingerprinting of brain cancer
Creators: name: Murugappan, Sivasubramanian
name: TOFAIL, SYED ANSAR
name: Thorat, Nanasaheb
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 460102
subject: Applications in health

description: Brain cancer is one of those few cancers with very high mortality and low five-year survival rate. First and foremost reason for the woes is the difficulty in diagnosing and monitoring the progression of brain tumors both benign and malignant, noninvasively and in real time. This raises a need in this hour for a tool to diagnose the tumors in the earliest possible time frame. On the other hand, Raman spectroscopy which is well-known for its ability to precisely represent the molecular markers available in any sample given, including biological ones, with great sensitivity and specificity. This has led to a number of studies where Raman spectroscopy has been used in brain tumors in various ways. This review article highlights the fundamentals of Raman spectroscopy and its types including conventional Raman, SERS, SORS, SRS, CARS, etc. are used in brain tumors for diagnostics, monitoring, and even theragnostics, collating all the major works in the area. Also, the review explores how Raman spectroscopy can be even more effectively used in theragnostics and the clinical level which would make them a one-stop solution for all brain cancer needs in the future
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (104)]
Creators: name: Airoldus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1189
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Airoldus und seine genannten Brüder, Söhne des Ianonus aus Casalbuttano, verkaufen mit Zustimmung des Sicardus, Bischof von Cremona, der canonica der Kathedrale von Cremona ein Vierzigstel des castrum Casalbuttano und weiteren Ländereien.
Providing reliability in Recommender Systems through Bernoulli Matrix Factorization
Creators: name: Ortega, Fernando
name: Lara-Cabrera, Raúl
name: González-Prieto, Ángel
name: Bobadilla, Jesús
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Information Retrieval (cs.IR)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: I.5.1

description: Beyond accuracy, quality measures are gaining importance in modern recommender systems, with reliability being one of the most important indicators in the context of collaborative filtering. This paper proposes Bernoulli Matrix Factorization (BeMF), which is a matrix factorization model, to provide both prediction values and reliability values. BeMF is a very innovative approach from several perspectives: a) it acts on model-based collaborative filtering rather than on memory-based filtering, b) it does not use external methods or extended architectures, such as existing solutions, to provide reliability, c) it is based on a classification-based model instead of traditional regression-based models, and d) matrix factorization formalism is supported by the Bernoulli distribution to exploit the binary nature of the designed classification model. The experimental results show that the more reliable a prediction is, the less liable it is to be wrong: recommendation quality improves after the most reliable predictions are selected. State-of-the-art quality measures for reliability have been tested, which shows that BeMF outperforms previous baseline methods and models.
description: 28 pages, 8 figures, 8 tables
Molecular markers of drug resistance and clinical outcome in falciparum malaria in Cambodia and the Democratic Republic of Congo
Creators: name: Alker, Alisa P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Background. Drug resistance is a major obstacle to the control of Plasmodium falciparum malaria. Monitoring the efficacy of antimalarials is a critical component to malaria control. One possible surveillance method is to use molecular markers. However, their relationship with clinical resistance needs to be established before they can be used. Methods. Clinical samples from an in vivo efficacy study of sulfadoxine-pyrimethamine (SP) based therapy in Rutshuru, Democratic Republic of Congo were used to estimate the effect of mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) on treatment failure. In addition, clinical samples from an in vivo efficacy study of mefloquineartesunate in Pailin, Cambodia were used to estimate the effect of changes in the P. falciparum multidrug resistance-1 (pfmdr1) gene on recrudescence. Lastly, a cross-sectional survey of Cambodia was conducted to determine the geographic distribution of the genetic changes in pfmdr1. Results. In Rutshuru, the effect of mutations at dhps-437 and dhps-540 on SP treatment failure differed by level of parasitemia: for children with low parasitemia, the presence of both mutations was associated with a 17% (95%CI: -3%, 36%) greater absolute risk of treatment failure compared to having neither mutation (baseline risk: 21%). For children with high parasitemia, the risk difference was 50% (95%CI: 35%, 64%; baseline risk: 8%). In Pailin, pfmdr1 copy number was strongly related to time to recrudescence after mefloquine-artesunate treatment (adjusted HR = 7.91, 95%CI: 2.38, 26.29). In the cross-sectional study of Cambodia, increased pfmdr1 copy number was found not only in Pailin, where mefloquine resistance has been well documented, but also in Chumkiri, an area not previously known for drug resistance. Conclusion. These studies demonstrated dhps mutations are associated with SP treatment failure in the DRC and pfmdr1 copy number is associated with recrudescence after mefloquine-artesunate treatment in Cambodia. The cross-sectional study demonstrates how the use of a molecular marker can be operationalized to detect resistant areas outside of current sentinel surveillance sites. Detecting dhps mutations in DRC and pfmdr1 copy number in Cambodia are potentially cost-effective methods to complement the current in vivo efficacy monitoring of drug resistance in these countries.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (107)]
Creators: name: Wilielmus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1191
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Wilielmus, genannt Caprarius, schenkt Sicardus, Bischof von Cremona, alle seine beweglichen und unbeweglichen Güter, einen Geldbetrag und ein Stück Land, das bisher vom Bistum gepachtet wurde, und erhält die Garantie, lebenslang mit Nahrung und Kleidung aus dieser Schenkung versorgt zu werden.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (108)]
Creators: name: Sicardus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1193
Subjects: subject: Bischofsurkunde
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Sicardus, Bischof von Cremona, verleiht dem Templum von Cremona, vertreten durch frater Martinus, magister domus dieser Kirche, Rechte und steckt ihre Grenzen ab.
Cobalamin-Fluorophores’ Photochemistry and Biomedical Applications
Creators: name: Rodgers, Zachary
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: As science focuses on the finer details of complex processes occurring in biology, the need for tools responsive to researcher control have become critical to communicate with cellular functions in both a spatial and temporal manner. To this end, light responsive “caging groups” have been used to generate molecular constructs with which researchers can activate using directed irradiation to elicit biological responses where and when they want. This advancement in molecular control has greatly improved our ability to study biological systems in their dynamically intricate form. Most of these photoresponsive moieties perform well within a petri dish, but their application is limited in vivo. Current photochemical tools require high energy light for their activation. Dermal tissue contains bio chromophores that absorb this light and prevents its penetration to less than a few millimeters making photoactivation impossible. However, tissue has an “optical window” in the red and near infrared (600 – 1000 nm) where light penetrates efficiently to clinically relevant depths. Therefore, researchers have sought long wavelength responsive caging groups but have had little success to date. Herein, I report the development of an entire class of red and near infrared responsive (600 – 800 nm) caging groups based on Vitamin B12 or cobalamin. Upon modification with a fluorophore antenna, these metal complexes can capture long wavelength light to perform photochemical work in the form of bond scission reactions. The effect is compatible with a range of fluorophores covering the entire near infrared spectrum, and bond scission proceeds rapidly with extremely high efficiencies. In this work, the initial development and characterization of these molecules as photoactivateable groups will be discussed. Furthermore, I will demonstrate how these molecules can be applied for clinical applications, such as drug delivery and tissue scaffold formation, to provide safer and less invasive treatments.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (109)]
Creators: name: Opitio
name: Oliuerius
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1193
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Die Brüder Opitio und Oliuerius aus Casalbuttano belehnen Bonsaperis und Girardus de Laude mit zwei Stück Land in Casalbuttano.
The role of the cyanobacteria toxin, microcystin, in aqueous iron biogeochemistry
Creators: name: Klein, Annaleise Renate
Publisher: name: La Trobe
Year: 2023

description: Thesis with publications.

Submission note: A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Ecology, Environment, and Evolution, School of Life Sciences, College of Science, Health, and Engineering, La Trobe University, Victoria.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (110)]
Creators: name: , Petrus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1196
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Petrus, archipresbyter und praepositus der Kathedrale von Cremona, investiert die Brüder Zaninus und Andreola, Söhne des verstorbenen Ugo de Cacitono, mit zwei Stück Land in bei St. Sauini.
Remote Access Mössbauer Spectrometry
Creators: name: Silaev, A. A.
name: Godovikov, S. K.
name: Postnikov, E. B.
name: Radchenko, V. V.
name: Silaev, A. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics Education (physics.ed-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The authors' design for a Mössbauer spectroscopy unit accessed via the Internet is presented. The spectrometer's configuration, operational peculiarities, key specifications, and remote access procedures are described. More detailed educational, scientific, and technical information can be found at the project's official website http://efmsb.sinp.msu.ru.
description: 5 pages, 6 figures
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (111)]
Creators: name: Airoldus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1196
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Airoldus, genannt aus Casalbuttano, und seine genannten Brüder belehnen Iohannes de Orsolario mit einem Stück Land in Casalbuttano, in Braida Tempestata.
IMMEDIATE EFFECTS OF ACUTE EXPERIMENTAL WEIGHT GAIN ON FEMORAL ARTICULAR CARTILAGE DEFORMATION FOLLOWING WALKING
Creators: name: Perrella, Cassie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: The hallmark characteristic of knee osteoarthritis (OA) is a decline in cartilage health. Weight gain increases joint stress and is a primary risk factor for OA. The purpose of this study was to compare the change in femoral articular cartilage cross- sectional area (ΔCSA) following a non-weighted versus weighted walking protocol, and to determine the association between ΔCSA and QBM. ΔCSA was measured using a diagnostic ultrasound before and after walking. We found no significant difference in ΔCSA between conditions. QBM was not associated with ΔCSA in the non-weighted (r=0.027, ∆R2 = 0.004, p = 0.731) or weighted (r=0.046, ∆R2 = 0.003, p = 0.762) conditions. Participants responded to non-weighted walking by remaining constant, decreasing, or increasing in CSA and were placed into groups. We found a significant interaction effect for ΔCSA between groups and condition (F2,29 = 6.384, p = 0.005), suggesting that cartilage’s response to load may be non-uniform.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (117)]
Creators: name: , Petrus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1196
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Petrus, archipresbyter und praepositus der Kathedrale von Cremona, investiert mit Zustimmung der übrigen Kanoniker den Cremosianus de Casanova mit einem Stück Land, gelegen ad carbonariam, gegen festgesetzte Abgaben.
New volume and inverse volume operators for loop quantum gravity
Creators: name: Yang, Jinsong
name: Ma, Yongge
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A new alternative volume operator is constructed for loop quantum gravity by using the so-called cotriad operators as building blocks. It is shown that the new volume operator shares the same qualitative properties with the standard volume operator. Moreover, a new alternative inverse volume operator is also constructed in the light of the construction of the alternative volume operator, which is possessed of the same qualitative properties as those of the alternative volume operator. The new inverse volume operator can be employed to construct the Hamiltonian operator of matter fields, which may lead to an anomaly-free on-shell quantum constraint algebra without any special restriction on the regularization procedure for gravity coupled to matter fields.
description: 14 pages, 1 figure; version published in PRD