cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In Vivo Effects of Histone H3 Depletion on Nucleosome Occupancy and Position in Saccharomyces cerevisiae
Creators: name: Lieb, Jason D.
name: Gossett, Andrea J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Previous studies in Saccharomyces cerevisiae established that depletion of histone H4 results in the genome-wide transcriptional de-repression of hundreds of genes. To probe the mechanism of this transcriptional de-repression, we depleted nucleosomes in vivo by conditional repression of histone H3 transcription. We then measured the resulting changes in transcription by RNA–seq and in chromatin organization by MNase–seq. This experiment also bears on the degree to which trans-acting factors and DNA–encoded elements affect nucleosome position and occupancy in vivo. We identified ∼60,000 nucleosomes genome wide, and we classified ∼2,000 as having preferentially reduced occupancy following H3 depletion and ∼350 as being preferentially retained. We found that the in vivo influence of DNA sequences that favor or disfavor nucleosome occupancy increases following histone H3 depletion, demonstrating that nucleosome density contributes to moderating the influence of DNA sequence on nucleosome formation in vivo. To identify factors important for influencing nucleosome occupancy and position, we compared our data to 40 existing whole-genome data sets. Factors associated with promoters, such as histone acetylation and H2A.z incorporation, were enriched at sites of nucleosome loss. Nucleosome retention was linked to stabilizing marks such as H3K36me2. Notably, the chromatin remodeler Isw2 was uniquely associated with retained occupancy and altered positioning, consistent with Isw2 stabilizing histone–DNA contacts and centering nucleosomes on available DNA in vivo. RNA–seq revealed a greater number of de-repressed genes (∼2,500) than previous studies, and these genes exhibited reduced nucleosome occupancy in their promoters. In summary, we identify factors likely to influence nucleosome stability under normal growth conditions and the specific genomic locations at which they act. We find that DNA–encoded nucleosome stability and chromatin composition dictate which nucleosomes will be lost under conditions of limiting histone protein and that this, in turn, governs which genes are susceptible to a loss of regulatory fidelity.
FUSE Observations of a Full Orbit of Scorpius X-1
Creators: name: Boroson, Bram
name: Vrtilek, Saeqa Dil
name: Raymond, John
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We obtained UV spectra of X-ray binary Scorpius X-1 in the 900-1200 A range with the Far Ultraviolet Spectroscopic Explorer over the full 0.79 day binary orbit. The strongest emission lines are the doublet of O VI at 1032,1038 A and the C III complex at 1175 A. The spectrum is affected by a multitude of narrow interstellar absorption lines, both atomic and molecular. Examination of line variability and Doppler tomograms suggests emission from both the neighborhood of the donor star and the accretion disk. Models of turbulence and Doppler broadened Keplerian disk lines Doppler shifted with the orbit of the neutron star added to narrow Gaussian emission lines with undetermined Doppler shift fit the data with consistent values of disk radius, inclination, and radial line brightness profile. The Doppler shift of the narrow component with the orbit suggests an association with the donor star. We test our line models with previously analyzed near UV spectra obtained with the Hubble Space Telescope Goddard High Resolution Spectrograph and archival spectra obtained with the HST Cosmic Origins Spectrograph.
description: Accepted for publication in The Astrophysical Journal
On the counting of $O(N)$ tensor invariants
Creators: name: Avohou, Remi C.
name: Geloun, Joseph Ben
name: Dub, Nicolas
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: $O(N)$ invariants are the observables of real tensor models. We use regular colored graphs to represent these invariants, the valence of the vertices of the graphs relates to the tensor rank. We enumerate $O(N)$ invariants as $d$-regular graphs, using permutation group techniques. We also list their generating functions and give (software) algorithms computing their number at an arbitrary rank and an arbitrary number of vertices. As an interesting property, we reveal that the algebraic structure which organizes these invariants differs from that of the unitary invariants. The underlying topological field theory formulation of the rank $d$ counting shows that it corresponds to counting of coverings of the $d-1$ cylinders sharing the same boundary circle and with $d$ defects. At fixed rank and fixed number of vertices, an associative semi-simple algebra with dimension the number of invariants naturally emerges from the formulation. Using the representation theory of the symmetric group, we enlighten a few crucial facts: the enumeration of $O(N)$ invariants gives a sum of constrained Kronecker coefficients; there is a representation theoretic orthogonal base of the algebra that reflects its dimension; normal ordered 2-pt correlators of the Gaussian models evaluate using permutation group language, and further, via representation theory, these functions provide other representation theoretic orthogonal bases of the algebra.
description: 44 pages, 6 figures; typos fixed, references updated
Existence and regularity of weak solutions for a fluid interacting with a non-linear shell in three dimensions
Creators: name: Muha, Boris
name: Schwarzacher, Sebastian
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We study the unsteady incompressible Navier-Stokes equations in three dimensions interacting with a non-linear flexible shell of Koiter type. This leads to a coupled system of non-linear PDEs where the moving part of the boundary is an unknown of the problem. The known existence theory for weak solutions is extended to non-linear Koiter shell models. We introduce a-priori estimates that reveal higher regularity of the shell displacement beyond energy estimates. These are essential for non-linear Koiter shell models, since such shell models are non-convex (w.r.t.\ terms of highest order). The estimates are obtained by introducing new analytical tools that allow to exploit dissipative effects of the fluid for the (non-dissipative) solid. The regularity result depends on the geometric constitution alone and is independent of the approximation procedure; hence it holds for arbitrary weak solutions. The developed tools are further used to introduce a generalized Aubin-Lions type compactness result suitable for fluid-structure interactions.
Intronic Cis-Regulatory Modules Mediate Tissue-Specific and Microbial Control of angptl4/fiaf Transcription
Creators: name: Trent, Chad M.
name: Rawls, John F.
name: Jazwa, Amelia L.
name: Camp, J. Gray
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The intestinal microbiota enhances dietary energy harvest leading to increased fat storage in adipose tissues. This effect is caused in part by the microbial suppression of intestinal epithelial expression of a circulating inhibitor of lipoprotein lipase called Angiopoietin-like 4 (Angptl4/Fiaf). To define the cis-regulatory mechanisms underlying intestine-specific and microbial control of Angptl4 transcription, we utilized the zebrafish system in which host regulatory DNA can be rapidly analyzed in a live, transparent, and gnotobiotic vertebrate. We found that zebrafish angptl4 is transcribed in multiple tissues including the liver, pancreatic islet, and intestinal epithelium, which is similar to its mammalian homologs. Zebrafish angptl4 is also specifically suppressed in the intestinal epithelium upon colonization with a microbiota. In vivo transgenic reporter assays identified discrete tissue-specific regulatory modules within angptl4 intron 3 sufficient to drive expression in the liver, pancreatic islet β-cells, or intestinal enterocytes. Comparative sequence analyses and heterologous functional assays of angptl4 intron 3 sequences from 12 teleost fish species revealed differential evolution of the islet and intestinal regulatory modules. High-resolution functional mapping and site-directed mutagenesis defined the minimal set of regulatory sequences required for intestinal activity. Strikingly, the microbiota suppressed the transcriptional activity of the intestine-specific regulatory module similar to the endogenous angptl4 gene. These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer. This study provides a useful paradigm for understanding how microbial signals interact with tissue-specific regulatory networks to control the activity and evolution of host gene transcription.
Defining UML Family Members Using Prefaces
Creators: name: Cook, Steve
name: Kleppe, Anneke
name: Mitchell, Richard
name: Rumpe, Bernhard
name: Warmer, Jos
name: Wills, Alan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The Unified Modeling Language is extensible, and so can be regarded as a family of languages. Implicitly or explicitly, any particular UML model should be accompanied by a definition of the particular UML family member used for the model. The definition should cover syntactic and semantic issues. This paper proposes a mechanism for associating models with such definitions. Any particular definition would form what we call a preface. The name is intended to suggest that the definition of a particular UML family member must conceptually come before any model built using that family member. A preface would be large, and should be organised using packages. This would allow large amounts of sharing between different prefaces. The paper proposes that prefaces should have an axiomatic style of semantics, through not necessarily fully formal, and it offers a general approach to semantics that would reduce problems of inconsistency within a large preface, based on the idea of general cases and special cases
description: 13 pages, 5 figures
A kinematically distinct core and minor-axis rotation: the MUSE perspective on M87
Creators: name: Emsellem, Eric
name: Krajnovic, Davor
name: Sarzi, Marc
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present evidence for the presence of a low-amplitude kinematically distinct component in the giant early-type galaxy M87, via datasets obtained with the SAURON and MUSE integral-field spectroscopic units. The MUSE velocity field reveals a strong twist of ~140 deg within the central 30 arcsec connecting outwards such a kinematically distinct core to a prolate-like rotation around the large-scale photometric major-axis of the galaxy. The existence of these kinematic features within the apparently round central regions of M87 implies a non-axisymmetric and complex shape for this galaxy, which could be further constrained using the presented kinematics. The associated orbital structure should be interpreted together with other tracers of the gravitational potential probed at larger scales (e.g., Globular Clusters, Ultra Compact Dwarfs, Planetary Nebulae): it would offer an insight in the assembly history of one of the brightest galaxies in the Virgo Cluster. These data also demonstrate the potential of the MUSE spectrograph to uncover low-amplitude spectral signatures.
description: Accepted for publication in MNRAS Letters, 5 pages, 4 figures
Mutational Signatures of De-Differentiation in Functional Non-Coding Regions of Melanoma Genomes
Creators: name: Margulies, Elliott H.
name: Bhanot, Umesh K.
name: Parker, Stephen C. J.
name: Song, Lingyun
name: Hansen, Nancy F.
name: Furey, Terrence S.
name: Ozel Abaan, Hatice
name: Ajay, Subramanian S.
name: Cardenas-Navia, Isabel
name: Meltzer, Paul S.
name: Gartner, Jared
name: Crawford, Gregory E.
name: Rosenberg, Steven A.
name: Mullikin, James C.
name: Samuels, Yardena
name: Gindin, Yevgeniy
name: Killian, J. Keith
name: Walker, Robert L.
name: Wei, Xiaomu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Much emphasis has been placed on the identification, functional characterization, and therapeutic potential of somatic variants in tumor genomes. However, the majority of somatic variants lie outside coding regions and their role in cancer progression remains to be determined. In order to establish a system to test the functional importance of non-coding somatic variants in cancer, we created a low-passage cell culture of a metastatic melanoma tumor sample. As a foundation for interpreting functional assays, we performed whole-genome sequencing and analysis of this cell culture, the metastatic tumor from which it was derived, and the patient-matched normal genomes. When comparing somatic mutations identified in the cell culture and tissue genomes, we observe concordance at the majority of single nucleotide variants, whereas copy number changes are more variable. To understand the functional impact of non-coding somatic variation, we leveraged functional data generated by the ENCODE Project Consortium. We analyzed regulatory regions derived from multiple different cell types and found that melanocyte-specific regions are among the most depleted for somatic mutation accumulation. Significant depletion in other cell types suggests the metastatic melanoma cells de-differentiated to a more basal regulatory state. Experimental identification of genome-wide regulatory sites in two different melanoma samples supports this observation. Together, these results show that mutation accumulation in metastatic melanoma is nonrandom across the genome and that a de-differentiated regulatory architecture is common among different samples. Our findings enable identification of the underlying genetic components of melanoma and define the differences between a tissue-derived tumor sample and the cell culture created from it. Such information helps establish a broader mechanistic understanding of the linkage between non-coding genomic variations and the cellular evolution of cancer.
Body image and somatic learning: cultivating bodymind in actor learning at UVPA theatre program in Sri Lanka
Creators: name: Liyanage, Saumya
Publisher: name: La Trobe
Year: 2023

description: This paper was presented at the FIRT/IFTR International Federation for Theatre Research Annual Conference, Santiago 2012, CHILE, July 22th - 28th, 2012.

This paper presents a way of Cultivating embodied knowing in acting through body-image (Scheilder 1970, Tiemersma 1989). Building upon the notion that the body-image is a mode of pre-existing knowledge of the body (Merleau-Ponty 1962), this research seeks to provide an epistemic pathway to actor knowing by sensing and performing “postural bodily-images” in actor training research conducted at the theatre and drama department, University of the Visual and Performing Arts (UVPA) Colombo, Sri Lanka. Recent studies in soma-aesthetics and dance studies have suggested that performer’s sensuous and proprioceptive faculties can be heightened through the practice of somatic activities (Shusterman 2000, 2004, Rouhiainan 2008, Parviainan 1998, Sheets-Johnston 1966). Consequently, ethical and emotional relationships between self and other bodies are also being enriched. Pursuing bodily-image as a somatic action (Noë 2004) and performing those bodily-images via varied postural modules, student actors have shown the ability to tap into their “primordial bodies” and cultivate somatic awareness of the self and other bodies. Consequently this paper incorporates an ethno-phenomenological approach to validate the claim that actor’s body is the “primary mode of knowing” in actor learning.

['International Federation for Theatre Research Annual Conference (2012 : Santiago, Chile.)']
Quantum and Non-local Effects Offer LiDAR over 40dB Advantage
Creators: name: Blakey, Phillip S.
name: Liu, Han
name: Papangelakis, Georgios
name: Zhang, Yutian
name: Leger, Zacharie M.
name: Iu, Meng Lon
name: Helmy, Amr S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Non-local effects have the potential to radically move forward quantum enhanced LiDAR to provide an advantage over classical LiDAR not only in laboratory environments but practical implementation. In this work, we demonstrate a 43dB lower signal-to-noise ratio using a quantum enhanced LiDAR based on time-frequency entanglement compared with a classical phase-insensitive LiDAR system. Our system can tolerate more than 3 orders of magnitude higher noise than classical singlephoton counting LiDAR systems before detector saturation. To achieve these advantages, we use non-local cancellation of dispersion to take advantage of the strong temporal correlations in photon pairs in spite of the orders of magnitude larger detector temporal uncertainty. We go on to incorporate this scheme with purpose-built scanning collection optics to image non-reflecting targets in an environment with noise.
description: 6 pages, 4 figures
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Creators: name: Beekman, Marian
name: Bidulescu, Aurelian
name: Yuan, Xin
name: Hivert, Marie-France
name: Rasmussen-Torvik, Laura J.
name: Kanoni, Stavroula
name: Pankow, James S.
name: Greenwood, Celia M. T.
name: Tanaka, Toshiko
name: Kooner, Jaspal
name: Morris, Andrew P.
name: Kizer, Jorge R.
name: Heid, Iris M.
name: Timpson, Nicholas
name: Qi, Lu
name: Manning, Alisa K.
name: Uh, Hae-Won
name: Perry, John R. B.
name: Lyytikäinen, Leo-Pekka
name: Ladouceur, Martin
name: Scott, Robert A.
name: Liu, Ching-Ti
name: Dastani, Zari
name: Small, Kerrin
name: Grimsby, Jonna
name: Coassin, Stefan
name: Fuchsberger, Christian
name: Mooser, Vincent E.
name: Wu, Ying
name: Isaacs, Aaron
name: Henneman, Peter
name: Lohman, Kurt
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8–1.2×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10−4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10−3, n = 22,044), increased triglycerides (p = 2.6×10−14, n = 93,440), increased waist-to-hip ratio (p = 1.8×10−5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10−3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10−13, n = 96,748) and decreased BMI (p = 1.4×10−4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
"A Lamp in a Windless Place that Flickers not": some reflections on self-cultivation in Sri Lankan theatre acting
Creators: name: Liyanage, Saumya
Publisher: name: La Trobe
Year: 2023

description: This paper was presented at the 2012 ADSA conference "Compass points: locations, landscapes and coordinates of identities" held on the 3-6 July 2012, Queensland University of Technology, Brisbane.

Paradigms of actor training and the embodiment of acting are invariably defined and understood according to the somaesthetic practices indigenous to the particular culture in which they are developed (Zarrilli 2002). As this title indicates, “a lamp that flickers not” (Bhagawat Gita, vi, 19) refers to the likeness of the seated Yogi and the “presence” of the body sculpture that the ascetic meditator cultivates through an assiduous practice of seated meditation. This metaphor of stillness of the body reflects the fundamental somatic quality that an actor achieves through the process of cultivating bodymind in acting. Habituating “self-cultivation” (Yuasa 1987) in meditational, medicinal, martial arts and artistry in Asia is one such modality via which practitioners cultivate inner and outer–inter involvement as a unified experience of the body. This ontology is thus identified in different disciplines by various terms such as “mindfulness/awareness” (Varela et el 2008), “body consciousness” (Shusterman 2008), “presence” (Barba 2005), “stillness/motionlessness” (Zarrilli 2009, Zusuki 2002) or the “attunement” (Nagatomo, 1992). Informed by Buddhist philosophy, this paper attempts to apply this theory of self-cultivation to contemporary Sri Lankan actor learning by looking at actor’s “attunement” with the physical score and the process of “habit formation” as a way of attaining “Samādhi” (bodymind) awareness of acting. In doing so this paper suggests an alternative paradigm of actional and epistemic pathway of actor learning.

['Australasian Association for Theatre. Drama and Performance Studies (2012 : Queensland University of Technology, Brisbane.)']
Gibbs Phenomena for $L^q$-Best Approximation in Finite Element Spaces -- Some Examples
Creators: name: Houston, Paul
name: Roggendorf, Sarah
name: van der Zee, Kristoffer G.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N30, 41A10

description: Recent developments in the context of minimum residual finite element methods are paving the way for designing finite element methods in non-standard function spaces. This, in particular, permits the selection of a solution space in which the best approximation of the solution has desirable properties. One of the biggest challenges in designing finite element methods are non-physical oscillations near thin layers and jump discontinuities. In this article we investigate Gibbs phenomena in the context of $L^q$-best approximation of discontinuities in finite element spaces with $1\leq q<\infty$. Using carefully selected examples, we show that on certain meshes the Gibbs phenomenon can be eliminated in the limit as $q$ tends to $1$. The aim here is to show the potential of $L^1$ as a solution space in connection with suitably designed meshes.
The Iwasawa Main conjecture of constant ordinary abelian varieties over function fields
Creators: name: Lai, King Fai
name: Longhi, Ignazio
name: Tan, Ki-Seng
name: Trihan, Fabien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We study a geometric analogue of the Iwasawa Main Conjecture for constant ordinary abelian varieties over $\ZZ_p^d$-extensions of function fields ramifying at a finite set of places.
description: 19 pages. arXiv admin note: substantial text overlap with arXiv:1205.5945
Nucleolar Association and Transcriptional Inhibition through 5S rDNA in Mammals
Creators: name: Starmer, Joshua
name: Magnuson, Terry
name: Yee, Della
name: Fedoriw, Andrew M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Changes in the spatial positioning of genes within the mammalian nucleus have been associated with transcriptional differences and thus have been hypothesized as a mode of regulation. In particular, the localization of genes to the nuclear and nucleolar peripheries is associated with transcriptional repression. However, the mechanistic basis, including the pertinent cis- elements, for such associations remains largely unknown. Here, we provide evidence that demonstrates a 119 bp 5S rDNA can influence nucleolar association in mammals. We found that integration of transgenes with 5S rDNA significantly increases the association of the host region with the nucleolus, and their degree of association correlates strongly with repression of a linked reporter gene. We further show that this mechanism may be functional in endogenous contexts: pseudogenes derived from 5S rDNA show biased conservation of their internal transcription factor binding sites and, in some cases, are frequently associated with the nucleolus. These results demonstrate that 5S rDNA sequence can significantly contribute to the positioning of a locus and suggest a novel, endogenous mechanism for nuclear organization in mammals.
QuaRL: Quantization for Fast and Environmentally Sustainable Reinforcement Learning
Creators: name: Krishnan, Srivatsan
name: Lam, Maximilian
name: Chitlangia, Sharad
name: Wan, Zishen
name: Barth-Maron, Gabriel
name: Faust, Aleksandra
name: Reddi, Vijay Janapa
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Deep reinforcement learning continues to show tremendous potential in achieving task-level autonomy, however, its computational and energy demands remain prohibitively high. In this paper, we tackle this problem by applying quantization to reinforcement learning. To that end, we introduce a novel Reinforcement Learning (RL) training paradigm, \textit{ActorQ}, to speed up actor-learner distributed RL training. \textit{ActorQ} leverages 8-bit quantized actors to speed up data collection without affecting learning convergence. Our quantized distributed RL training system, \textit{ActorQ}, demonstrates end-to-end speedups \blue{between 1.5 $\times$ and 5.41$\times$}, and faster convergence over full precision training on a range of tasks (Deepmind Control Suite) and different RL algorithms (D4PG, DQN). Furthermore, we compare the carbon emissions (Kgs of CO2) of \textit{ActorQ} versus standard reinforcement learning \blue{algorithms} on various tasks. Across various settings, we show that \textit{ActorQ} enables more environmentally friendly reinforcement learning by achieving \blue{carbon emission improvements between 1.9$\times$ and 3.76$\times$} compared to training RL-agents in full-precision. We believe that this is the first of many future works on enabling computationally energy-efficient and sustainable reinforcement learning. The source code is available here for the public to use: \url{https://github.com/harvard-edge/QuaRL}.
description: Equal contribution from first three authors. Updating with QuaRL for sustainable (carbon emissions) RL results
مطالعه تطبیقی مراکز محله ای شهر یزد بر مبنای شاخص های مرکز محله ایده آل با رویکرد تحلیلی FMEA (مطالعه موردی: مرکز محله "یعقوبی" در بافت تاریخی و "پشت سیلو" در بافت جدید شهر یزد)
Publisher: name: دانشگاه کردستان
Year: 2018

description: تحولات ایجاد شده در دهه های اخیر و نیز عدم توجه به ویژگی های یک مرکز محله مطلوب و کارآمد در هر بستری و مطابق\nبا نظرات و خواسته های استفاده کنندگان از این فضاها موجب بروز مشکلاتی از جنبه های مختلف در مراکز محله ای شده\nاست. هدف اصلی این پژوهش، شناسایی مسائل و مشکلات پیرامون دو مرکز محله یعقوبی در بافت تاریخی و مرکز محله\nپشت سیلو در بافت جدید شهر یزد و تحلیل آنها از طریق تکنیک اف.ام.ای.ای(که اساسا با هدف دستیابی به حد ایده آل کیفیت\nمورد استفاده قرار میگیرد) میباشد. با به کارگیری تکنیک یاد شده در عرصه شهرسازی و کالیبره نمودن آن با مفاهیم موجود\nدر این عرصه، می توان به شناسایی و حل مشکلات فضاهای شهری به روشی اصولی و کارآمد دست یافت. این پژوهش\nاز نوع کاربردی و در بخش تدوین مبانی نظری به روش توصیفی و با استناد به مطالعات کتابخانه ای بوده و در بخش دوم\nکه مربوط به دو مرکز محله در شهر یزد می باشد، به روش توصیفی_تحلیلی و از طریق مطالعات و برداشت های میدانی، به\nکمک مصاحبه و پرسشنامه و با تأکید بر تکنیک(اف.ام.ای.ای) صورت می پذیرد. مهمترین نتایج این پژوهش در بخش مقایسه\nدو مرکز محله یعقوبی و پشت سیلو است که نتایج به کارگیری تکنیک(اف.ام.ای.ایی) نشان میدهد، مرکز محله یعقوبی در عین\nوجود برخی کاستی ها با توجه به نیازها و شرایط امروزی، به دلیل پیاده مداری و قرارگیری فضا در سطح ادراک انسانی، فعال\nبودن کاربری های تجاری محلی و همچنین ترکیب مطلوب کارکردهای برانگیزاننده حضور ساکنان نسبت به مرکز محله\nپشت سیلو وضعیت به مراتب بهتری را داراست. براساس نتایج تحلیلی و اولویت بندی مسائل، راهکارهای پیشنهادی برای\nبهبود وضعیت در دو مرکز محله یاد شده ارائه گردیده است. در نهایت جمع بندی پژوهش به ارائه نکات و آموزه هایی برگرفته\nاز مرکز محله یعقوبی برای ارتقای کیفی مرکز محله پشت سیلو متناسب با شرایط بافت های جدید اختصاص یافته است
A Polyhedral Homotopy Algorithm For Real Zeros
Creators: name: Ergür, Alperen A.
name: de Wolff, Timo
Publisher: name: arXiv
Year: 2019
Subjects: subject: Algebraic Geometry (math.AG)
subject: Computational Geometry (cs.CG)
subject: Numerical Analysis (math.NA)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 14P05, 14P25, 14T05, 68R05, 52B11, 65D99, 65Y20

description: We design a homotopy continuation algorithm, that is based on numerically tracking Viro's patchworking method, for finding real zeros of sparse polynomial systems. The algorithm is targeted for polynomial systems with coefficients satisfying certain concavity conditions. It operates entirely over the real numbers and tracks the optimal number of solution paths. In more technical terms; we design an algorithm that correctly counts and finds the real zeros of polynomial systems that are located in the unbounded components of the complement of the underlying A-discriminant amoeba.
description: revision incorporating referee remarks
Nonstationary Spatial Modeling of Massive Global Satellite Data
Creators: name: Huang, Huang
name: Blake, Lewis R.
name: Katzfuss, Matthias
name: Hammerling, Dorit M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Earth-observing satellite instruments obtain a massive number of observations every day. Despite their size, such datasets are incomplete and noisy, necessitating spatial statistical inference to obtain complete, high-resolution fields with quantified uncertainties. Such inference is challenging due to the high computational cost and the nonstationary behavior of environmental processes on a global scale. Classical methods for constructing complete maps of environmental variables can be overly simplistic and result in opaque uncertainties, thereby limiting the scientific application of these data. In this work, we address the need to construct complete, high resolution maps of geophysical processes (Level 3 data) from incomplete, noisy, georeferenced observations (Level 2 data). We develop a multi-resolution approximation (M-RA) of a Gaussian process (GP) whose nonstationary, global covariance function is obtained using local fits. We consider sea surface temperature (SST) as an application to illustrate the workflow and our computational implementation. The M-RA requires domain partitioning, which can be application-specific. In the SST case, we partition the domain purposefully to account for and weaken dependence across land barriers. Our M-RA implementation is tailored to distributed-memory computation in high-performance-computing environments. We analyze a Moderate Resolution Imaging Spectroradiometer (MODIS) SST dataset consisting of more than 43 million observations, to our knowledge the largest dataset ever analyzed using a probabilistic GP model. We show that our nonstationary model based on local fits provides substantially improved predictive performance relative to a stationary approach, which already improves upon current methods. Supplementary materials for this article are available online.
Key barriers to ICT uptake in foreign language teaching in Vietnam: a case study
Creators: name: Dang, Xuan Thu
name: Nicholas, Howard
name: Lewis, Ramon
Publisher: name: La Trobe
Year: 2023

description: Information and communications technology (ICT) has a high profile in education and has been increasingly integrated into teaching and learning at all levels in Vietnam. Logically, ICT, which is perceived to bring about numerous positive benefits, should be warmly received by all teachers. However, this is not the case for foreign language teachers in Vietnam. This paper provides a critical analysis of key obstacles to ICT uptake in foreign language teaching at tertiary level in Vietnam. This is a result of a case study at Hanoi University (HANU). The data were collected from 222 survey questionnaires and 43 semi-structured interviews with HANU teaching staff, leadership and ICT experts. The findings show that barriers existed at both institutional and teacher levels. Lack of guidelines, training and support for ICT use in teaching, and limited resources were among the key barriers. The implications of the study are also discussed. Developing objective understanding of the inhibiting factors could be significant for successful ICT integration into modern language teaching in the future. Keywords: ICT, integration, barriers, foreign language teaching, Vietnam.

['International Technology, Education and Development Conference. [6th : 2012 : Valencia, Spain]']
funcX: Federated Function as a Service for Science
Creators: name: Li, Zhuozhao
name: Chard, Ryan
name: Babuji, Yadu
name: Galewsky, Ben
name: Skluzacek, Tyler
name: Nagaitsev, Kirill
name: Woodard, Anna
name: Blaiszik, Ben
name: Bryan, Josh
name: Katz, Daniel S.
name: Foster, Ian
name: Chard, Kyle
Publisher: name: arXiv
Year: 2022
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: funcX is a distributed function as a service (FaaS) platform that enables flexible, scalable, and high performance remote function execution. Unlike centralized FaaS systems, funcX decouples the cloud-hosted management functionality from the edge-hosted execution functionality. funcX's endpoint software can be deployed, by users or administrators, on arbitrary laptops, clouds, clusters, and supercomputers, in effect turning them into function serving systems. funcX's cloud-hosted service provides a single location for registering, sharing, and managing both functions and endpoints. It allows for transparent, secure, and reliable function execution across the federated ecosystem of endpoints--enabling users to route functions to endpoints based on specific needs. funcX uses containers (e.g., Docker, Singularity, and Shifter) to provide common execution environments across endpoints. funcX implements various container management strategies to execute functions with high performance and efficiency on diverse funcX endpoints. funcX also integrates with an in-memory data store and Globus for managing data that may span endpoints. We motivate the need for funcX, present our prototype design and implementation, and demonstrate, via experiments on two supercomputers, that funcX can scale to more than 130 000 concurrent workers. We show that funcX's container warming-aware routing algorithm can reduce the completion time for 3000 functions by up to 61% compared to a randomized algorithm and the in-memory data store can speed up data transfers by up to 3x compared to a shared file system.
description: arXiv admin note: substantial text overlap with arXiv:2005.04215
Exotic phase separation in one-dimensional hard-core boson system with two- and three-body interactions
Creators: name: Cheng, Chen
name: Mao, Bin-Bin
name: Chen, Fu-Zhou
name: Luo, Hong-Gang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate the ground state phase diagram of hard-core boson system with repulsive two-body and attractive three-body interactions in one-dimensional optic lattice. When these two interactions are comparable and increasing the hopping rate, physically intuitive analysis indicates that there exists an exotic phase separation regime between the solid phase with charge density wave order and superfluid phase. We identify these phases and phase transitions by numerically analyzing the density distribution, structure factor of density-density correlation function, three-body correlation function and von Neumann entropy estimator obtained by density matrix renormalization group method. These exotic phases and phase transitions are expected to be observed in the ultra-cold polar molecule experiments by properly tuning interaction parameters, which is constructive to understand the physics of ubiquitous insulating-superconducting phase transitions in condensed matter systems.
معیارهای اصلی شکل گیری حس مکان در پهنه های توسعه جدید شهری (نمونه مطالعه:منطقه 22 و منطقه 4 شهرداری تهران)
Publisher: name: دانشگاه کردستان
Year: 2018

description: پژوهش حاضر با مطالعه حس مکان و مفاهیم مرتبط با آن، به تبیین معیارهای اصلی در ارتقای حس مکان در توسعه جدید\nشهرها پرداخته است. در چارچوب هدف یاد شده و براساس مبانی نظری، 10معیار اصلی شامل غنای بصری، تناسبات\nبصری، کیفیت کالبدی فضایی، خوانایی، قابلیت ادرا ک مکان، هویت و شخصیت، قابلیت دسترسی، انعطاف پذیری،\nآسایش و دعوت کننده و جذاب بودن مکان، در زمینه شکل گیری و تشخیص حس مکان از نقطه نظر ساکنان توسعه\nجدید شهری تدوین شد.بررسی و تبیین بیشتر این 10معیار، به واسطه 42زیرمعیار با استناد به انجام تحلیل عاملی مورد\nتوجه قرار گرفته است. به منظور عملیاتی شدن چارچوب نظری تدوین شده، مطالعه موردی شامل شهرک های دهکده\nالمپیک، چشمه، پیکانشهر و امید از منطقه 22شهرداری تهران، به عنوان بزرگترین توسعه شهری جدید متصل به تهران و\nهمچنین محله حکیمیه از منطقه 4شهرداری تهران به عنوان یکی دیگر از توسعه ً های نسبتا جدید تهران انتخاب شدند که\nبا استفاده از روش آلفای کرونباخ حجم نمونه در مجموع  1070نفر تعیین شده است. همچنین از روشهای آماری مدلسازی\nمعادلات ساختاری، برآورد حداکثر درست نمایی، آزمون همبستگی پیرسون و مدل رگرسیون خطی چندگانه برای تعیین\nماهیت رابطه میان انگاره حس مکان و معیارهای ده گانه فوق استفاده شده است. در نهایت امکان طرح مدل 10عاملی در\nزمینه مطالعه و سنجش حس مکان در پهنه های توسعه جدید شهری فراهم شده که کفایت برازندگی این مدل به واسطه\nشاخص های مختلف نشان میدهد، الگوی مورد نظر از نظر هماهنگی داده ها با ساختار عاملی آن، از برازندگی قابل قبولی\nبرخوردار است
Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast
Creators: name: Chandramowlishwaran, Pavithra
name: Mieczkowski, Piotr
name: Chernoff, Yury O.
name: Sherman, Michael Y.
name: Gokhale, Kavita
name: Allen, Kim D.
name: Gong, He
name: Romanova, Nina V.
name: Newnam, Gary P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing endogenous QN-rich proteins in the aggregated (prion) form. Attachment of the proline(P)-rich region targets polyglutamines to the large perinuclear deposit (aggresome). Aggresome formation ameliorates polyglutamine cytotoxicity in cells containing only the prion form of Rnq1 protein. Here we show that expanded polyglutamines both with (poly-QP) or without (poly-Q) a P-rich stretch remain toxic in the presence of the prion form of translation termination (release) factor Sup35 (eRF3). A Sup35 derivative that lacks the QN-rich domain and is unable to be incorporated into aggregates counteracts cytotoxicity, suggesting that toxicity is due to Sup35 sequestration. Increase in the levels of another release factor, Sup45 (eRF1), due to either disomy by chromosome II containing the SUP45 gene or to introduction of the SUP45-bearing plasmid counteracts poly-Q or poly-QP toxicity in the presence of the Sup35 prion. Protein analysis confirms that polyglutamines alter aggregation patterns of Sup35 and promote aggregation of Sup45, while excess Sup45 counteracts these effects. Our data show that one and the same mode of polyglutamine aggregation could be cytoprotective or cytotoxic, depending on the composition of other aggregates in a eukaryotic cell, and demonstrate that other aggregates expand the range of proteins that are susceptible to sequestration by polyglutamines.
Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor
Creators: name: Lee, Sang Hong
name: Keller, Matthew C.
name: Howrigan, Daniel P.
name: Neale, Ben M.
name: Ripke, Stephan
name: Sullivan, Patrick F.
name: Gejman, Pablo V.
name: Simonson, Matthew A.
name: Lencz, Todd
name: Levinson, Douglas F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by ∼17% for every 1% increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time.
شناسایی اثرات گردشگری و نقش آن در توسعه شهری کاشان
Publisher: name: دانشگاه کردستان
Year: 2018

description: صنعت گردشگری به عنوان یکی از صنایع برتر در حال توسعه، امروزه جایگاه خاصی در اقتصاد کشورها داشته و با اثرات\nخود نقش فعال و مؤثری بر بهبود ساختار اقتصادی، اجتماعی_ فرهنگی و محیطی جوامع ایفا میکند. با توجه به اهمیت\nفزاینده گردشگری، تحلیل آثار آن بر سایر ابعاد ضرورتی ویژه خواهد داشت.شهر کاشان با برخورداری از توانها و فرصت های\nویژه گردشگری، در ابعاد متفاوت اقتصادی، اجتماعی، زیست محیطی و کالبدی از این پدیده متأثر شده است. در این\nراستا هدف از انجام پژوهش حاضر، شناسایی آثار گردشگری و نقش آن در توسعه شهری کاشان است. پژوهش به لحاظ\nهدف، کاربردی و از نظر ماهیت و روش از نوع تحقیقات توصیفی_تحلیلی است. حجم نمونه با استفاده از فرمول کوکران\nبه تعداد  200نفر محاسبه گردید. ابزار پژوهش، پرسشنامه محقق ساخت های با  65متغیر است که روایی آن با استفاده از\nنظر متخصصان و پایایی آن با استفاده از آزمون آلفای کرونباخ به میزان  0/738مورد تأیید قرار گرفت. برای تجزیه و تحلیل\nنتایج پرسشنامه از روش های مختلف آماری و نرم افزارهای اس.پی.اس.اس و ایموس استفاده شده است. نتایج حاصل از کاربرد\nمدلسازی معادلات ساختاری نشان میدهد، توسعه گردشگری اثر معناداری بر توسعه شهری در کاشان داشته است. این\nاثرگذاری دارای بار عاملی  0/29و سطح معناداری  0/000بوده که با استناد به آن میتوان گفت در سطح اطمینان 99درصد\nگردشگری بر توسعه شهری کاشان اثرگذار بوده است. در شاخصهای تبیین کننده توسعه شهری رشد خدمات فرهنگی\n(کتابخانه، مساجد و )... با بار عاملی  0/67بیش از سایر ابعاد از توسعه گردشگری اثر پذیرفته است. بار عاملی  0/66برای\nتوسعه تسهیلات و خدمات زیربنایی و عمرانی (شبکه آب و فاضلاب، مخابرات و )... این شاخص را در جایگاه دوم قرار داده\nاست. همچنین معناداری اثر گردشگری بر بهبود معیشت ساکنان با بار عاملی  0/65و سطح معناداری  0/000مورد تأیید\nقرار میگیرد. کسب بار عاملی  0/52برای افزایش خدمات عمومی (خدمات بهداشتی، جمعآوری زباله و)... متأثر از توسعه\nگردشگری این شاخص را در رتبه چهارم اثرپذیری از گردشگری در مجموعه متغیرهای تبیین کننده توسعه شهری قرار\nمیدهد
S Phase–Coupled E2f1 Destruction Ensures Homeostasis in Proliferating Tissues
Creators: name: Davidson, Jean M.
name: Duronio, Robert J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. E2F transcription factors are activated during G1 to drive the G1-S transition and are then inhibited during S phase by a variety of mechanisms. Here, we genetically manipulate the single Drosophila activator E2F (E2f1) to explore the developmental requirement for S phase–coupled E2F down-regulation. Expression of an E2f1 mutant that is not destroyed during S phase drives cell cycle progression and causes apoptosis. Interestingly, this apoptosis is not exclusively the result of inappropriate cell cycle progression, because a stable E2f1 mutant that cannot function as a transcription factor or drive cell cycle progression also triggers apoptosis. This observation suggests that the inappropriate presence of E2f1 protein during S phase can trigger apoptosis by mechanisms that are independent of E2F acting directly at target genes. The ability of S phase-stabilized E2f1 to trigger apoptosis requires an interaction between E2f1 and the Drosophila pRb homolog, Rbf1, and involves induction of the pro-apoptotic gene, hid. Simultaneously blocking E2f1 destruction during S phase and inhibiting the induction of apoptosis results in tissue overgrowth and lethality. We propose that inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
NDD: A 3D Point Cloud Descriptor Based on Normal Distribution for Loop Closure Detection
Creators: name: Zhou, Ruihao
name: He, Li
name: Zhang, Hong
name: Lin, Xubin
name: Guan, Yisheng
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Loop closure detection is a key technology for long-term robot navigation in complex environments. In this paper, we present a global descriptor, named Normal Distribution Descriptor (NDD), for 3D point cloud loop closure detection. The descriptor encodes both the probability density score and entropy of a point cloud as the descriptor. We also propose a fast rotation alignment process and use correlation coefficient as the similarity between descriptors. Experimental results show that our approach outperforms the state-of-the-art point cloud descriptors in both accuracy and efficency. The source code is available and can be integrated into existing LiDAR odometry and mapping (LOAM) systems.