cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficacy, tolerance and acceptability of pulsed dye laser on facial and neckline telangiectasias in systemic scleroderma: a prospective open-label monocentric study in 21 patients
Creators: name: Kottler, D.
name: Dupechez, L.
name: Silva, N. Martin
name: Boutemy, J.
name: Dumont, A.
name: Maigné, G.
name: Aouba, A.
name: Dompmartin, A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Facial and neckline telangiectasias have an underestimated yet important impact on quality of life of patients with systemic scleroderma (SSc). This monocentric, prospective, open-label, intra-patient comparative study was conducted in 21 consecutive patients with SSc. Patients underwent 4 sessions of PDL 8 weeks apart. A final quadruple assessment was performed by several raters 2 months after the last session, based on the following criteria: change in telangiectasia number; subjective improvement score (LINKERT scale); impact on the quality of life (QoL; SKINDEX score); visual analog pain scale; adverse effects (AEs), including treatment discontinuation for PDL-induced purpura and patient satisfaction. The mean telangiectasia number decreased by 5 (32%) at the end of the protocol. Eighteen patients (85.7%) reported an improvement or a strong improvement, versus 73.81% for the expert committee. Immediate session pain (mean = 3.4/10) was slightly less than overall pain (mean = 4.6/10). Ten patients (47%) experienced at least one AE (oozing/crusts, edema, epidermal blistering), including PDL-induced purpura in 3 patients (14%). AEs were mostly transient (<1 week) and mild (CTCAE grade 1). All QoL parameters improved after treatment, and 85% of patients were satisfied.
RelRank in Rayyan: A 5-star Rating Prediction System (RelRank) inside an Abstract Screening System (Rayyan)
Creators: name: Saha, Tanay Kumar
name: Hammady, Hossam
name: Ouzzani, Mourad
name: Hasan, Mohammad Al
Publisher: name: figshare
Year: 2017
Subjects: subject: Applied Computer Science
subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences

description: A systematic review attempts to collect and combine all empirical evidence to answer a specific research question that fits the pre-specified eligibility criteria. Explicit, systematic methods are selected with a view to minimizing bias. Therefore, Systematic reviews provide more reliable findings from which conclusions can be drawn and decisions made. A major task in systematic reviews is abstract screening, i.e., excluding, often hundreds or thousands of, irrelevant citations returned from searching one or multiple databases based on titles and abstracts. Thus, a systematic review platform that can automate the abstract screening process is of huge importance in making this process faster and more accurate. In this demo proposal, we present the performance and workflow of our 5-star rating prediction system (RelRank) implemented inside the Rayyan platform for systematic reviews.
A large-scale study of SVM-based methods for abstract screening in systematic reviews
Creators: name: Saha, Tanay Kumar
name: Ouzzani, Mourad
name: Hammady, Hossam
name: Elmagarmid, Ahmed K.
Publisher: name: figshare
Year: 2017
Subjects: subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences
subject: Information Systems

description: A major task in systematic reviews is abstract screening, i.e., excluding, often hundreds or thousand of, irrelevant citations returned from a database search based on titles and abstracts. Thus, a systematic review platform that can automate the abstract screening process is of huge importance. Several methods have been proposed for this task. However, it is very hard to clearly understand the applicability of these methods in a systematic review platform because of the following challenges:(1) the use of non-overlapping metrics for the evaluation of the proposed methods, (2) usage of features that are very hard to collect, (3) using a small set of reviews for the evaluation,and (4) no solid statistical testing or equivalence grouping of the methods. In this paper, we use feature representation that can be extracted per citation. We evaluate SVM based methods(commonly used) on a large set of reviews (61) and metrics (11) to provide equivalence grouping of methods based on a solid statistical test. Our analysis also includes a strong variability of the metrics using 500x2 cross validation. While some methods shine for different metrics and for different datasets, there is no single method that dominates the pack. Furthermore, we observe that in some cases relevant (included) citations can be found after screening only 15-20% of them via a certainty based sampling.A few included citations present outlying characteristics and can only be found after a very large number of screening steps.Finally, we present an ensemble algorithm for producing a 5-star rating of citations based on their relevance. Such algorithm combines the best methods from our evaluation and through its 5-star rating outputs a more easy-to-consume prediction.
Developing a Method for the Detection and Monitoring of Acid Mine Drainage (AMD) in Surface Water in the Donbas with Earth Observations
Creators: name: Walsh, Jonathan
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: Acid mine drainage · Coal mining areas · Surface water contamination · Sentinel-2 · Landsat 8 · Google Earth Engine

description: Acid mine drainage (AMD) contamination in surface water has potential for long-lasting environmental damage in coal mining regions across the world. Remote sensing methods have proven useful at monitoring the extent of AMD contamination, but have thus far been reliant on high levels of a priori knowledge of the study area and ground measurements. Using the case of the occupied Donbas (eastern Ukraine), this study proposes a novel method for the detection and monitoring of AMD in surface water bodies in inaccessible territories. The use of Sentinel-2 and Landsat 8 data with the Acid Mine Water Index (AMWI) is revealed as an effective tool for capturing long term trends in AMD on wider geographical scales. Around specific mining agglomerations, increases in surface water contamination consistent with flooding in mines were detected. The method shows promise for the use of Earth observations to gain insights into mine management practices in inaccessible territories, and the extent of possible environmental damage incurred from mismanagement as an indirect consequence of conflict.
title: Implementation and Evaluation of a Static Backwards Data Flow Analysis in FlowDroid
Creators: name: Lange, Tim
Publisher: name: UNSPECIFIED
Year: 2022

description: In the last decade, many static taint analysis tools based on IFDS have been proposed. Nearly all of them only have a single analysis direction, with most opting for a forward-directed analysis and some for a backward-directed analysis. In this thesis, we investigate the effect of the analysis direction on the runtime and memory consumption. We extended FlowDroid to feature a backward-directed analysis, which is equally precise as FlowDroid's forward analysis. We evaluated both implementations on DroidBench and 200 real-world apps. The results show that there is a favorable analysis direction for many apps and the right choice can reduce the runtime dramatically.
title: Hydrogen and organic molecules generation from water radiolysis: from grave to cradle
Creators: name:  Vandenborre ,   Johan
name:  Truche ,   Laurent
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Water radiolysis is a key process for hydrogen (H2) and abiotic organic molecules generation in the Earth’s crust. The aim of this presentation is to provide some insight into this process from a radiochemist viewpoint. We will transpose the knowledge we gain from water radiolysis in the context of radioactive waste disposal to natural geological settings and draw important conclusions for deep microbial ecosystems development and abiotic organic synthesis. Some examples will be given about: (i) the relationship between H2 production ant the nature of the emitted particle (α/β/γ) considered for water radiolysis, (ii) the boosted production of H2 observed when aqueous solutions are in contact with some mineral surfaces such as rutile (TiO2) and calcite (CaCO3), (iii) the scavenging role of carbonate anions onto hydroxyl radical and the amplified yield of H2, (iv) the switch from an inorganic world to an organic one through the carboxylate anions production from carbonate radiolysis. Radiation chemistry is often overlooked by geologists who consider the process as anecdotic (apart for the thermal budget of Earth) in term of mass balance. However, water radiolysis is a large-scale ubiquist process in the crust and it does not need specific conditions to occur. We will show that at geological time scale, water radiolysis leads to a very diverse, reactive, and fun chemistry able to sustain life and even to create the condition for its emergence.
Synthesis of 3-alkenylated indole and bis(indol-3-yl) derivatives catalyzed by sulfonic acid-functionalized ionic liquid under ultrasound irradiation
Creators: name: Budania, Saroj
name: Shelke, Ganesh M.
name: Kumar, Anil
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: A simple and efficient protocol has been developed for the synthesis of 3-alkenylated indoles and bis(indol-3-yl) derivatives by sulfonic acid-functionalized ionic liquid-catalyzed reaction of indole with 1,3-diketones/3-ketoesters under solvent-free ultrasound irradiation. Good to excellent yields (68–94%) are obtained in ultrasonication. The product of reaction is dependent on the substituent at C-2 position of indole. The catalyst is reusable and recyclable up to four cycles without significant loss of its catalytic activity. Compared with conventional heating, sound wave activation has the considerable advantages such as shorter reaction time, easy work-up, higher yields, and mild conditions.
title: Privacy Agents: Utilizing Large Language Models to Safeguard Contextual Integrity in Elderly Care
Creators: name: Grabler, Reinhard
name: Hirschmanner, Matthias
name: Frijns, Helena Anna
name: Köszegi, Sabine Theresia
Publisher: name: TU Wien
Year: 2024
Subjects: Privacy
Contextual Integrity
LLM
Elderly Care
Robotics

description: A value-based design process in the development of robotic technologies for elderly care requires approaches to protect privacy. With the rise of Large Language Models (LLMs) new use cases for robotic technology can be facilitated. In this paper we present a conceptual approach to utilizing LLMs to enhance privacy. We refer to a use case of a care documentation support agent that should aid care workers in their care routines. Our contribution is based on the understanding of Nissenbaum’s privacy as contextual integrity. We introduce a privacy agent that continuously monitors information flows of recorded conversations, and identifies key parameters that are compared to the contextual privacy norms to detect privacy violations.
WORTLPRESS ADMIN PANELIGA KIRISH VA SAYTGA MA'LUMOTLAR KIRITISHNI BOSLILASH
Creators: name: Qodirov Sardor Xusan o'g'li
Publisher: name: Zenodo
Year: 2024

description: Saytingiz uning ichidagi ma’lumotlari bilan qimmatli hisoblanadi. Shunday ekan, yangi ochilgan saytingizni hammaga kerakli, qiziqarli, foydali bo’lgan ma’lumotlar bilan boyiting!
Multivariate Functional Principal Component Analysis for Data Observed on Different (Dimensional) Domains
Creators: name: Happ, Clara
name: Greven, Sonja
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Existing approaches for multivariate functional principal component analysis are restricted to data on the same one-dimensional interval. The presented approach focuses on multivariate functional data on different domains that may differ in dimension, such as functions and images. The theoretical basis for multivariate functional principal component analysis is given in terms of a Karhunen–Loève Theorem. For the practically relevant case of a finite Karhunen–Loève representation, a relationship between univariate and multivariate functional principal component analysis is established. This offers an estimation strategy to calculate multivariate functional principal components and scores based on their univariate counterparts. For the resulting estimators, asymptotic results are derived. The approach can be extended to finite univariate expansions in general, not necessarily orthonormal bases. It is also applicable for sparse functional data or data with measurement error. A flexible R implementation is available on CRAN. The new method is shown to be competitive to existing approaches for data observed on a common one-dimensional domain. The motivating application is a neuroimaging study, where the goal is to explore how longitudinal trajectories of a neuropsychological test score covary with FDG-PET brain scans at baseline. Supplementary material, including detailed proofs, additional simulation results, and software is available online.
CoP's architecture and stakeholder mapping for each Living Lab
Creators: name: Rebelo, Margarida
name: Cardoso, Maria Adriana
name: Alegre, Helena
name: Andrews, Lisa
name: Mooren, Caro
name: Munaretto, Stefania
name: Gomes, Carla
name: Schmidt, Luísa
name: Oliveira, Rosário
name: Melo, Marcella
Publisher: name: Zenodo
Year: 2021

description: This deliverable introduces two tools: Communities of Practice (CoP) and the Innovation Alliance (InAll). Chapters 2 and 3 are dedicated to the CoP and include the roadmap for CoP implementation in all Living Labs of the B-WaterSmart (BWS) project (e.g. meeting planning, preparation and facilitation, community planning, roles of the Coordinator and the Moderator, evaluation framework and cross-fertilisation), stakeholder mapping for the six Living Labs and the ethical issues and procedures to be considered in CoP implementation. Chapter 4 presents the framework for implementating the BWS Innovation Alliance, in particular the definition of the concept, the objectives behind it, the Consortium’s experience to date in working with InAll, and the guidelines for implementation. The annexes provide practical information for CoP management, such as engagement tools for online meetings, moderation techniques organised by meeting elements and/or activities, a protocol for CoP Coordinators to follow when conductiong the meetings, a template for reporting on CoP meetings, the CoP evaluation form and consent forms to be used in CoP operations.
TRILOGI NOVEL GADIS TANGSI KARYA SUPARTO BRATA: KAJIAN PRAGMATISME PASCAKOLONIAL
Creators: name: Tirto Suwondo
Publisher: name: Zenodo
Year: 2015
Subjects: Pascakolonial, Pragmatisme

description: This study aims to describe and explain the five aspects of literary communication systems Trilogy of Gadis Tangsi Novel by Suparto Brata. Five aspects of it is the intention (author), representation (postcolonial), expression (verbal and nonverbal text), reference (thematic ideas), and projections (the reader). The basic concept of the theory used is postcolonial pragmatism (joint between the postcolonial and pragmatics theory). This study belongs to the type of qualitative research. The approach used is a critical approach. Data collected by the technique simak, interviews, and document research. Data validity is tested through triangulation (source, techniques, and theory). Data were analyzed by the method of deconstruction and analysis of content and messaging functions. This research resulted in findings (verbal descriptive) follows. First, from a review of the intentions of the author obtained an explanation that the postcolonial novel written by author deliberately wanted to convey the experience of the past history and culture that was used by the experience of the present generation and future as something meaningful. Second, from a review of postcolonial representation obtained explanation that Trilogy of Gadis Tangsi Novel represent postcolonial aspects, including power relations, identity, mimicry, and resistance. Third, from a review of the text expression obtained explanation that aspects of the postcolonial Trilogy of Gadis Tangsi Novel expressed through verbal form (narrative structure, space, time) and non-verbal (visual image). Fourth, from a review of the idea of thematic references (ideological) obtained explanation that aspects of the postcolonial Trilogy of Gadis Tangsi Novel can be a reference for the emergence of the idea of justice, wisdom, democratization, respect for self and others, dynamic, creative, independent, and national spirit and insight into the future. Fifth, from a review of the projections obtained by the explanation that the ideas in the Trilogy of Gadis Tangsi Novel can be used as a medium projection for exemplary readers to behave, think, and act; and therefore, is suitable for use as a novel teaching materials literature. For the Government of Indonesia, the results of this study can be used as a material consideration in the decision making related to the development of education (teaching) Indonesian language and literature. For managers and lecturers Indonesian Education Studies Program at the College, the results of this study can be used as an input for the development of research lectures and literary criticism. For the Indonesian language and literature teachers, the results of this study can be used as a language of learning materials and the development of Indonesian literature. Finally, for students and college students, the results of this study can be used as a source of learning in order to improve the ability of appreciation and study of literature.
СТИЛИСТИЧЕСКИЕ И ПРАГМАТИЧЕСКИЕ АСПЕКТЫ ПЕРЕВОДА РУССКИХ ФРАЗЕОЛОГИЗМОВ НА УЗБЕКСКИЙ ЯЗЫК В МЕДИЙНОМ ДИСКУРСЕ
Creators: name: Нормелиева Зилола Абдуахад кизи Джизакский Государственный Педагогический Университет им.А.Кадыри «Русский язык и литература», 1-курс магистратуры
Publisher: name: Zenodo
Year: 2025

description: В статье рассматриваются особенности перевода русских фразеологизмов на узбекский язык в контексте медийного дискурса. Особое внимание уделено этнокультурологическим, стилистическим и прагматическим аспектам перевода. Автор анализирует трудности, возникающие при передаче фразеологических единиц, и предлагает возможные стратегии адаптации с учётом лингвокультурных различий.
An evaluation of preference of delays to reinforcement on choice responding : a translational study
Creators: name: Shpall, Cayenne Sarah
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Delay to reinforcement
Mixed delays to reinforcement
Functional Communication Training
Challenging behavior
Treatment

description: Delays to reinforcement are often a necessary component during treatments of challenging behavior (e.g., Functional Communication Training; FCT). In the absence of programmed delay training, the utility and generality of FCT may be limited. Despite the importance of delays to reinforcement during FCT, few studies have empirically isolated and investigated the parameters pertaining to the implementation of delays to reinforcement. Results from basic empirical studies have shown that variable delays, or bi-valued mixed delays to reinforcement, are preferred in humans and nonhuman studies. The current research examined response allocation between fixed and mixed delays to reinforcement using a concurrent schedule of reinforcement. Results showed preference for mixed delays to reinforcement with 4 out of 4 participants. Potential avenues of future research on the use of mixed delays to reinforcement, such as the application within FCT and maintenance of socially appropriate behaviors, are discussed.
Retail Agglomeration and Competition Externalities: Evidence from Openings and Closings of Multiline Department Stores in the U.S.
Creators: name: Clapp, John M.
name: Ross, Stephen L.
name: Tingyu Zhou
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology

description: From the perspective of an existing retailer, the optimal size of a cluster of retail activity represents a trade-off between the marginal increases in consumer attraction from another store against the depletion of the customer base caused by an additional competitor. We estimate opening and closing probabilities of multi-line department stores (“anchors”) as a function of preexisting anchors by type of anchor store (low-priced, mid-priced, or high-priced) using a bias-corrected probit model with county and year fixed effects. We find strong negative competitive effects of an additional same type but no effect on openings of anchors of another type. Supplementary materials for this article are available online.
Synthesis of 3-Alkenylated Indole and Bis(indol-3-yl) Derivatives Catalyzed by Sulfonic Acid Functionalized Ionic Liquid Under Ultrasound Irradiation
Creators: name: Budania, Saroj
name: Shelke, Ganesh M.
name: Kumar, Anil
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: A simple and efficient protocol has been developed for the synthesis of 3-alkenylated indoles and bis(indol-3-yl) derivatives by sulfonic acid functionalized ionic liquids (SFIL) catalyzed reaction of indole with 1,3-diketones/3-ketoesters under solvent free ultrasound irradiation. Good to excellent yields (68-94%) are obtained in ultrasonication. The product of the reaction is dependent on the substituent at C-2-position of indole. The catalyst is reusable and recyclable up to four cycles without significant loss of its catalytic activity. Compared with conventional heating, sound wave activation has the considerable advantages such as shorter reaction times, easy work-up, higher yields and mild conditions.
D2.1 Riparian Ecotone Citizen Science
Creators: name: Gumiero, Bruna
name: Veronesi, Leonardo
name: Loiselle, Steven
name: Galgani, Luisa
Publisher: name: Zenodo
Year: 2024
Subjects: subject: riparian zone
subject: citizen science
subject: public perception
subject: Freshwater ecosystems
subject: Geomorphology
subject: Freshwater biology

description: This work is part of OTTERS - citizen science for water stewardship" - WP2 "The large body of EU projects and programs with citizen science experience as well as recent publications on the topic will be surveyed to identify insights, lessons learned, and knowledge gaps with respect to the three broad issues outlined in the WP Objectives section above. The review will focus on identifying factors that can contribute to greater effectiveness of CS in participatory researchers and innovation. It will see if there are novel ways in which CS can contribute to such research. The project and literature survey will also focus on understanding how much we know and understand (and gaps in knowledge) about the effectiveness of CS in changing behaviour of people (esp., young ones) toward more marine and freshwater ecosystems. Does engaging in CS increase ocean literacy and agency? Does it make people behave more responsibly? What evidence is cited for such behavioural change? Finally, the project and literaturesurvey will look into experiences, opportunities, and challenges of engaging special stakeholders. The reviews will besummarised into 3 draft white papers"

 

This work focuses on the ecosystem services of riparian corridors, from geomorphology to vegetation dynamics, as well as policy and management implications. A special focus is devoted to the public's perception and the media description of riparian zones, with the case study being the Emilia-Romagna flooding of May 2023.
description: This is one of three deliverables from the WP2 of EU-funded project "OTTERS - citizen science for water stewardship". The other two deliverables - also published in Zenodo - are titled "The role of citizen science within WFD and SDGs, and how to incentivize the collaboration with environmental regulators" and "Citizen Science as a contributor to the Marine Strategy Framework Directive implementation".
Accurate Small Tail Probabilities of Sums of iid Lattice-Valued Random Variables via FFT
Creators: name: Huon Wilson
name: Keich, Uri
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Accurately computing very small tail probabilities of a sum of independent and identically distributed lattice-valued random variables is numerically challenging. The only general purpose algorithms that can guarantee the desired accuracy have a quadratic runtime complexity that is often too slow. While fast Fourier transform (FFT)-based convolutions have an essentially linear runtime complexity, they can introduce overwhelming roundoff errors. We present sisFFT (segmented iterated shifted FFT), which harnesses the speed of FFT while retaining control of the relative error of the computed tail probability. We rigorously prove the method’s accuracy and we empirically demonstrate its significant speed advantage over existing accurate methods. Finally, we show that sisFFT sacrifices very little, if any, speed when FFT-based convolution is sufficiently accurate to begin with. Supplementary material is available online.
Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus
Creators: name: Liang, Qiulian
name: Huang, Gongchen
name: Li, Ruiqi
name: Qin, Linyuan
name: Zhong, Ping
name: Xiang-yuan, Yu
Publisher: name: Zenodo
Year: 2024
Subjects: gestational diabetes mellitus
Functional polymorphism
Genetic susceptibility

description: The dataset contains subjects' basic information, including the Identification number of the test sample, fasting plasma glucose (FPG), oral glucose tolerance test 1h plasma glucose (1hPG), oral glucose tolerance test 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), Systolic blood pressure (SBP), Diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-c), Low-density lipoprotein cholesterol (LDL-c), and also involves subjects' genetic variant information used for analysis of the association of functional polymorphisms and GDM. The variables including SBP_M, DBP_M, FPG_M, 1hPG_M, 2hPG_M, HbA1c_M, TG_M represent the mean value of SBP, DBP, FPG, 1hPG, 2hPG, HbA1c, TG, which are used for the stratification analysis. This study has obtained the support from the Ethics Committee of Guilin Medical University. All included subjects signed the informed consent.
description: Funding provided by: Natural Science Foundation of Guangxi Zhuang Autonomous RegionCrossref Funder Registry ID: http://dx.doi.org/10.13039/100012547Award Number: 2020GXNSFAA238025
Funding provided by: Middle-aged and Young Teachers' Basic Ability Promotion Project of GuangxiCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100012434Award Number: 2020KY12028
Retail Agglomeration and Competition Externalities: Evidence from Openings and Closings of Multiline Department Stores in the US
Creators: name: Clapp, John M.
name: Ross, Stephen L.
name: Tingyu Zhou
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology

description: From the perspective of an existing retailer, the optimal size of a cluster of retail activity represents a trade-off between the marginal increases in consumer attraction from another store against the depletion of the customer base caused by an additional competitor. We estimate opening and closing probabilities of multi-line department stores (“anchors”) as a function of pre-existing anchors by type of anchor store (low-priced, mid-priced or high-priced) using a bias corrected probit model with county and year fixed effects. We find strong negative competitive effects of an additional same type but no effect on openings of anchors of another type.
Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study.
Creators: name: Usman, Ammara
name: Patterson, Andrew J
name: Yuan, Jianmin
name: Cluroe, Alison
name: Patterson, Ilse
name: Graves, Martin J
name: Gillard, Jonathan H
name: Sadat, Umar
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Ferumoxytol is an ultrasmall super paramagnetic particles of iron oxide (USPIO) agent recently used for magnetic resonance (MR) vascular imaging. Other USPIOs have been previously used for assessing inflammation within atheroma. We aim to assess feasibility of ferumoxytol in imaging carotid atheroma (with histological assessment); and the optimum MR imaging time to detect maximum quantitative signal change post-ferumoxytol infusion. Ten patients with carotid artery disease underwent high-resolution MR imaging of their carotid arteries on a 1.5 T MR system. MR imaging was performed before and at 24, 48, 72 and 96 hrs post ferumoxytol infusion. Optimal ferumoxytol uptake time was evaluated by quantitative relaxometry maps indicating the difference in T2* (ΔT2*) and T2 (ΔT2) between baseline and post-Ferumoxytol MR imaging using 3D DANTE MEFGRE qT2*w and iMSDE black-blood qT2w sequences respectively. 20 patients in total (10 symptomatic and 10 with asymptomatic carotid artery disease) had ferumoxytol-enhanced MR imaging at the optimal imaging window. 69 carotid MR imaging studies were completed. Ferumoxytol uptake (determined by a decrease in ΔT2* and ΔT2) was identified in all carotid plaques (symptomatic and asymptomatic). Maximum quantitative decrease in ΔT2* (10.4 [3.5-16.2] ms, p
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.
Creators: name: Kaalund, Sanne Simone
name: Passamonti, Luca
name: Allinson, Kieren S J
name: Murley, Alexander G
name: Robbins, Trevor W
name: Spillantini, Maria Grazia
name: Rowe, James B
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Locus coeruleus
Tau
Neurodegeneration
Frontotemporal Dementia
Progressive Supranuclear Palsy
Noradrenalin

description: The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour. Neurodegeneration and pathological aggregation of tau protein in the locus coeruleus are early features of progressive supranuclear palsy (PSP). This pathology is proposed to contribute to the clinical expression of disease, including the PSP Richardson's syndrome. We test the hypothesis that tau pathology and neuronal loss are associated with clinical heterogeneity and severity in PSP.We used immunohistochemistry in post mortem tissues from 31 patients with a clinical diagnosis of PSP (22 with Richardson's syndrome) and 6 control cases. We quantified the presence of hyperphosphorylated tau, the number of pigmented cells indicative of noradrenergic neurons, and the percentage of pigmented neurons with tau-positive inclusions. Ante mortem assessment of clinical severity using the PSP rating scale was available within 1.8 (±0.9) years for 23 patients.We found an average 49% reduction of pigmented neurons in PSP patients relative to controls. The loss of pigmented neurons correlated with disease severity, even after adjusting for disease duration and the interval between clinical assessment and death. The degree of neuronal loss was negatively associated with tau-positive inclusions, with an average of 44% of pigmented neurons displaying tau-inclusions.Degeneration and tau pathology in the locus coeruleus are related to clinical heterogeneity of PSP. The noradrenergic deficit in the locus coeruleus is a candidate target for pharmacological treatment. Recent developments in ultra-high field magnetic resonance imaging to quantify in vivo structural integrity of the locus coeruleus may provide biomarkers for noradrenergic experimental medicines studies in PSP.
title: Dr. hc. Philipp Etter, Bundesrat
title: 21. Dezember 1891 - 23. Dezember 1977
titleType: Subtitle
Creators: name: Hürlimann, Hans
name: Salis, Jean Rudolf Von
name: Stalder, Johannes
name: Stadlin, Paul
Publisher: name: [Verlag nicht ermittelbar]
Year: 1978
Subjects: subject: 320 Politikwissenschaft
subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Etter, Philipp
subject: Bern
subject: Dreifaltigkeitskirche Bern

description: Enthält: Gedenkworte von Herrn Bundesrat Dr. Hans Hürlimann am 23. Dezember 1977 im «Echo der Zeit» von Radio DRS ; Nachruf von Herrn Prof. Dr. Jean R. von Salis vom 23. Dezember 1977 im Fernsehen DRS ; Ansprache von H. H. Pfarrer Johannes Stalder beim Trauergottesdienst vom 28. Dezember 1977 in der Dreifaltigkeitskirche in Bern ; Gedenkrede von Herrn Bundesrat Dr. Hans Hürlimann beim Trauergottesdienst vom 28. Dezember 1977 in der Dreifaltigkeitskirche in Bern ; Gedenkworte im Zuger Kantonsrat von Ratspräsident Herrn Dr. Paul Stadlin anlässlich der Sitzung vom 23. Februar 1978
Genomic analysis on broiler-associated Clostridium perfringens strains and exploratory caecal microbiome investigation reveals key factors linked to poultry necrotic enteritis.
Creators: name: Kiu, Raymond
name: Brown, Joseph
name: Bedwell, Harley
name: Leclaire, Charlotte
name: Caim, Shabhonam
name: Pickard, Derek
name: Dougan, Gordon
name: Dixon, Ronald A
name: Hall, Lindsay J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Poultry
Clostridium perfringens
Toxin
Phylogenomics
Necrotic Enteritis
16S Rrna Analysis
Caecal Microbiome

description: Background:Clostridium perfringens is a key pathogen in poultry-associated necrotic enteritis (NE). To date there are limited Whole Genome Sequencing based studies describing broiler-associated C. perfringens in healthy and diseased birds. Moreover, changes in the caecal microbiome during NE is currently not well characterised. Thus, the aim of this present study was to investigate C. perfringens virulence factors linked to health and diseased chickens, including identifying putative caecal microbiota signatures associated with NE. Results:We analysed 88 broiler chicken C. perfringens genomes (representing 66 publicly available genomes and 22 newly sequenced genomes) using different phylogenomics approaches and identified a potential hypervirulent and globally-distributed clone spanning 20-year time-frame (1993-2013). These isolates harbored a greater number of virulence genes (including toxin and collagen adhesin genes) when compared to other isolates. Further genomic analysis indicated exclusive and overabundant presence of important NE-linked toxin genes including netB and tpeL in NE-associated broiler isolates. Secondary virulence genes including pfoA, cpb2, and collagen adhesin genes cna, cnaA and cnaD were also enriched in the NE-linked C. perfringens genomes. Moreover, an environmental isolate obtained from farm animal feeds was found to encode netB, suggesting potential reservoirs of NetB-positive C. perfringens strains (toxinotype G). We also analysed caecal samples from a small sub-set of 11 diseased and healthy broilers for exploratory microbiome investigation using 16S rRNA amplicon sequencing, which indicated a significant and positive correlation in genus Clostridium within the wider microbiota of those broilers diagnosed with NE, alongside reductions in beneficial microbiota members. Conclusions:These data indicate a positive association of virulence genes including netB, pfoA, cpb2, tpeL and cna variants linked to NE-linked isolates. Potential global dissemination of specific hypervirulent lineage, coupled with distinctive microbiome profiles, highlights the need for further investigations, which will require a large worldwide sample collection from healthy and NE-associated birds.
Inferring structural variant cancer cell fraction.
Creators: name: Cmero, Marek
name: Yuan, Ke
name: Ong, Cheng Soon
name: Schröder, Jan
name: Corcoran, Niall M
name: Papenfuss, Tony
name: Hovens, Christopher M
name: Markowetz, Florian
name: Macintyre, Geoff
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whole-genome sequencing data. SVclone accurately determines the variant allele frequencies of both SV breakends, then simultaneously estimates the cancer cell fraction and SV copy number. We assess performance using in silico mixtures of real samples, at known proportions, created from two clonal metastases from the same patient. We find that SVclone's performance is comparable to single-nucleotide variant-based methods, despite having an order of magnitude fewer data points. As part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) consortium, which aggregated whole-genome sequencing data from 2658 cancers across 38 tumour types, we use SVclone to reveal a subset of liver, ovarian and pancreatic cancers with subclonally enriched copy-number neutral rearrangements that show decreased overall survival. SVclone enables improved characterisation of SV intra-tumour heterogeneity.
The evolutionary history of 2,658 cancers.
Creators: name: Gerstung, Moritz
name: Jolly, Clemency
name: Leshchiner, Ignaty
name: Dentro, Stefan C
name: Gonzalez, Santiago
name: Rosebrock, Daniel
name: Mitchell, Thomas J
name: Rubanova, Yulia
name: Anur, Pavana
name: Yu, Kaixian
name: Tarabichi, Maxime
name: Deshwar, Amit
name: Wintersinger, Jeff
name: Kleinheinz, Kortine
name: Vázquez-García, Ignacio
name: Haase, Kerstin
name: Jerman, Lara
name: Sengupta, Subhajit
name: Macintyre, Geoff
name: Malikic, Salem
name: Donmez, Nilgun
name: Livitz, Dimitri G
name: Cmero, Marek
name: Demeulemeester, Jonas
name: Schumacher, Steven
name: Fan, Yu
name: Yao, Xiaotong
name: Lee, Juhee
name: Schlesner, Matthias
name: Boutros, Paul C
name: Bowtell, David D
name: Zhu, Hongtu
name: Getz, Gad
name: Imielinski, Marcin
name: Beroukhim, Rameen
name: Sahinalp, S Cenk
name: Ji, Yuan
name: Peifer, Martin
name: Markowetz, Florian
name: Mustonen, Ville
name: Yuan, Ke
name: Wang, Wenyi
name: Morris, Quaid D
name: Spellman, Paul T
name: Wedge, David C
name: Van Loo, Peter
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)4, we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.
Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation.
Creators: name: Moest, Markus
name: Van Belleghem, Steven M
name: James, Jennifer E
name: Salazar, Camilo
name: Martin, Simon H
name: Barker, Sarah L
name: Moreira, Gilson R P
name: Mérot, Claire
name: Joron, Mathieu
name: Nadeau, Nicola J
name: Steiner, Florian M
name: Jiggins, Chris D
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Natural selection leaves distinct signatures in the genome that can reveal the targets and history of adaptive evolution. By analysing high-coverage genome sequence data from 4 major colour pattern loci sampled from nearly 600 individuals in 53 populations, we show pervasive selection on wing patterns in the Heliconius adaptive radiation. The strongest signatures correspond to loci with the greatest phenotypic effects, consistent with visual selection by predators, and are found in colour patterns with geographically restricted distributions. These recent sweeps are similar between co-mimics and indicate colour pattern turn-over events despite strong stabilising selection. Using simulations, we compare sweep signatures expected under classic hard sweeps with those resulting from adaptive introgression, an important aspect of mimicry evolution in Heliconius butterflies. Simulated recipient populations show a distinct 'volcano' pattern with peaks of increased genetic diversity around the selected target, characteristic of sweeps of introgressed variation and consistent with diversity patterns found in some populations. Our genomic data reveal a surprisingly dynamic history of colour pattern selection and co-evolution in this adaptive radiation.
Accurate small tail probabilities of sums of iid lattice-valued random variables via FFT
Creators: name: Huon Wilson
name: Keich, Uri
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Accurately computing very small tail probabilities of a sum of independent and identically distributed lattice-valued random variables is numerically challenging. The only general purpose algorithms that can guarantee the desired accuracy have a quadratic runtime complexity which is often too slow. While Fast Fourier Transform (FFT)-based convolutions have an essentially linear runtime complexity, they can introduce overwhelming roundoff errors. We present sisFFT (segmented iterated shifted FFT), which harnesses the speed of FFT while retaining control of the relative error of the computed tail probability. We rigorously prove the method's accuracy and we empirically demonstrate its significant speed advantage over existing accurate methods. Finally, we show that sisFFT sacrifices very little, if any, speed when FFT based convolution is sufficiently accurate to begin with. Supplementary material is available online.
Genetic influence is linked to cortical morphology in category-selective areas of visual cortex.
Creators: name: Abbasi, Nooshin
name: Duncan, John
name: Rajimehr, Reza
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Human visual cortex contains discrete areas that respond selectively to specific object categories such as faces, bodies, and places. A long-standing question is whether these areas are shaped by genetic or environmental factors. To address this question, here we analyzed functional MRI data from an unprecedented number (n = 424) of monozygotic (MZ) and dizygotic (DZ) twins. Category-selective maps were more identical in MZ than DZ twins. Within each category-selective area, distinct subregions showed significant genetic influence. Structural MRI analysis revealed that the 'genetic voxels' were predominantly located in regions with higher cortical curvature (gyral crowns in face areas and sulcal fundi in place areas). Moreover, we found that cortex was thicker and more myelinated in genetic voxels of face areas, while it was thinner and less myelinated in genetic voxels of place areas. This double dissociation suggests a differential development of face and place areas in cerebral cortex.
Boosting in the Presence of Outliers: Adaptive Classification With Nonconvex Loss Functions
Creators: name: Li, Alexander Hanbo
name: Bradic, Jelena
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This article examines the role and the efficiency of nonconvex loss functions for binary classification problems. In particular, we investigate how to design adaptive and effective boosting algorithms that are robust to the presence of outliers in the data or to the presence of errors in the observed data labels. We demonstrate that nonconvex losses play an important role for prediction accuracy because of the diminishing gradient properties—the ability of the losses to efficiently adapt to the outlying data. We propose a new boosting framework called ArchBoost that uses diminishing gradient property directly and leads to boosting algorithms that are provably robust. Along with the ArchBoost framework, a family of nonconvex losses is proposed, which leads to the new robust boosting algorithms, named adaptive robust boosting (ARB). Furthermore, we develop a new breakdown point analysis and a new influence function analysis that demonstrate gains in robustness. Moreover, based only on local curvatures, we establish statistical and optimization properties of the proposed ArchBoost algorithms with highly nonconvex losses. Extensive numerical and real data examples illustrate theoretical properties and reveal advantages over the existing boosting methods when data are perturbed by an adversary or otherwise. Supplementary materials for this article are available online.
Protocol for qualitative secondary analysis- Understanding and perceptions of social prescribing among primary care staff, voluntary sector representatives and patients in England.’ .pdf
Creators: name: Fattorini, Iva
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420605
subject: Preventative health care
classificationCode: 420603
subject: Health promotion
classificationCode: 420606
subject: Social determinants of health
classificationCode: 420699
subject: Public health not elsewhere classified

description: This reflexive thematic analysis will aim to answer the following research question: What is the meaning of social prescribing among patients, primary care staff and voluntary-community sector representatives based in England?