title: ÐÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð±Ð¸Ð¾ÑÐµÐ°ÐºÑÐ¾ÑÐ° Ð´Ð»Ñ ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Propionibacterium freundenreichii Ñ ÑÐµÐ»ÑÑ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð±Ð¸Ð¾Ð¼Ð°ÑÑÑ Ñ Ð²ÑÑÐ¾ÐºÐ¸Ð¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ Ð²Ð¸ÑÐ°Ð¼Ð¸Ð½Ð° Bââ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Design of a bioreactor for the cultivation of Propionibacterium freudenreichii to obtain biomass with a high content of vitamin B12
Creators: name: Ð¨Ð¸ ÐÑÑÐ½Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐºÐ¾Ð»Ð¾Ð½Ð¾ÑÐ½ÑÐ¹ Ð±Ð¸Ð¾ÑÐµÐ°ÐºÑÐ¾Ñ
Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
column bioreactor
design

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐºÐ¾Ð»Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð±Ð¸Ð¾ÑÐµÐ°ÐºÑÐ¾ÑÐ° Ñ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð¿ÐµÑÐµÐ¼ÐµÑÐ¸Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿ÑÐ¸ Ð¿Ð¾Ð¼Ð¾ÑÐ¸ ÑÑÑÐ±Ð¸Ð½Ð½Ð¾Ð¹ Ð¼ÐµÑÐ°Ð»ÐºÐ¸ Ð¾ÑÐºÑÑÑÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð°. Ð£ÑÑÑÐ¾Ð¹ÑÑÐ²Ð¾ Ð¾ÑÐ½Ð°ÑÐµÐ½Ð¾ Ð´Ð²ÑÐ¼Ñ ÑÐ¸Ð¿Ð°Ð¼Ð¸ ÑÐµÐ¿Ð»Ð¾Ð¾Ð±Ð¼ÐµÐ½Ð½ÑÑ ÑÑÑÑÐ¾Ð¹ÑÑÐ²: Ð²Ð½ÑÑÑÐµÐ½Ð½ÐµÐµ â ÑÐ¿Ð¸ÑÐ°Ð»ÑÐ½ÑÐ¹ Ð·Ð¼ÐµÐµÐ²Ð¸Ðº, Ð¸ Ð²Ð½ÐµÑÐ½ÐµÐµ â Ð¿ÑÐ¾ÑÑÐ°Ñ ÑÑÐ±Ð°ÑÐºÐ°. âÐÐ»Ñ Ð´Ð¾ÑÑÐ¸Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ Ð±ÑÐ»Ð¸ ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: â ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð¿Ð¾Ð¸ÑÐº Ð½Ð°ÑÑÐ½Ð¾-ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ Ð¿Ð¾ ÑÐµÐ¼Ðµ Ð¿ÑÐ¾ÐµÐºÑÐ°; â ÐÐ¾Ð´Ð¾Ð±ÑÐ°ÑÑ Ð°Ð¿Ð¿Ð°ÑÐ°Ñ Ð´Ð»Ñ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÑÐ»Ð¾Ð²Ð¸Ð¹ ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Propionibacterium freudenreichii Ñ ÑÐµÐ»ÑÑ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð±Ð¸Ð¾Ð¼Ð°ÑÑÑ Ñ Ð²ÑÑÐ¾ÐºÐ¸Ð¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ Ð²Ð¸ÑÐ°Ð¼Ð¸Ð½Ð° Bâ2 â Ð Ð°ÑÑÑÐ¸ÑÐ°ÑÑ Ð¼Ð°ÑÑÐ¾Ð¾Ð±Ð¼ÐµÐ½Ð½ÑÐµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ, Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÐ¹ Ð±Ð°Ð»Ð°Ð½Ñ ÑÐµÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð¸, ÑÐµÐ¿Ð»Ð¾Ð¾Ð±Ð¼ÐµÐ½Ð½ÑÐµ Ð¿ÑÐ¾ÑÐµÑÑÑ â ÑÐµÐ¿Ð»Ð¾Ð¾ÑÐ´Ð°ÑÐ° Ð±ÐµÐ· ÑÑÑÑÐ° Ð°ÑÑÐ°ÑÐ¸Ð¸, ÑÐ°ÑÑÑÐ¸ÑÐ°ÑÑ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÑ ÐÑÐ°Ð½Ð´ÑÐ»Ñ, ÐÑÑÑÐµÐ»ÑÑÐ°, Ð ÐµÐ¹Ð½Ð¾Ð»ÑÐ´ÑÐ°, Ð¼Ð¾ÑÐ½Ð¾ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ â ÐÑÐ¿Ð¾Ð»Ð½Ð¸ÑÑ ÑÐµÑÑÑÐ¶ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ðµ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Autodesk AutoCAD â ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¾Ð¿Ð°ÑÐ½ÑÑ Ð¸ Ð²ÑÐµÐ´Ð½ÑÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð², ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ Ð¸Ñ Ð¿ÑÐµÐ´ÑÐ¿ÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ. âÐ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ°ÑÑÑÑÐ¾Ð² Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð´Ð°Ð½Ð½ÑÐµ: ÑÐ°ÑÑÐ¾ÑÐ° Ð²ÑÐ°ÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°Ð»ÐºÐ¸: 1 Ñ-1; Ð¾Ð±ÑÑÐ¼Ð½ÑÐ¹ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½Ñ Ð¼Ð°ÑÑÐ¾Ð¿ÐµÑÐµÐ´Ð°ÑÐ¸ 0,34 Ñ-1; ÐºÑÐ¸ÑÐµÑÐ¸Ð¹ Ð ÐµÐ¹Ð½Ð¾Ð»ÑÐ´ÑÐ°: 1,151Â·105; ÐºÑÐ¸ÑÐµÑÐ¸Ð¹ ÐÑÐ°Ð½Ð´ÑÐ»Ñ: 7; ÐºÑÐ¸ÑÐµÑÐ¸Ð¹ ÐÑÑÑÐµÐ»ÑÑÐ°: 3325; Ð·Ð°Ð¿Ð°Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸: 1,8 ÐºÐÑ/(, ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð¹ Ð¿Ð¾ÑÐ¾Ðº ÑÑÐ±Ð°ÑÐºÐ¸: 5,9 ÐºÐÑ. 54
description: This work is devoted to the design of a column bioreactor with mechanical stirring using an open-type turbine agitator. The device is equipped with two types of heat exchange devices: the inner one is a spiral coil, and the outer one is a simple jacket. âTo achieve this goal, the following tasks were formulated: â To search for scientific and technical literature on the project topic; â To select an apparatus for creating optimal conditions for the cultivation of Propionibacterium freudenreichii in order to obtain biomass with a high content of vitamin B12; â Calculate mass transfer parameters, material balance of fermentation, heat exchange processes â heat transfer without aeration, calculate Prandtl, Nusselt, Reynolds coefficients, work capacity; â Execute a drawing in the Autodesk AutoCAD computer-aided design program; â To analyze dangerous and harmful production factors, to develop measures to prevent them. âAs a result of calculations, the following data were obtained: agitator rotation frequency: 1 s-1; volumetric mass transfer coefficient 0.34 s-1; Reynolds criterion: 1.151Â·105; Prandtl criterion: 7; Nusselt criterion: 3325; performance margin: 1.8 kW/(m2Â·K), jacket heat flow: 5.9 kW.