cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Sernbo score predicts 1-year mortality after displaced femoral neck fractures treated with a hip arthroplasty
Creators: name: Mellner, Carl
name: Eisler, Thomas
name: Börsbo, Johannes
name: Brodén, Cyrus
name: Morberg, Per
name: Mukka, Sebastian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Background and purpose — Displaced femoral neck fractures (FNFs) are associated with high rates of mortality during the first postoperative year. The Sernbo score (based on age, habitat, mobility, and mental state) can be used to stratify patients into groups with different 1-year mortality. We assessed this predictive ability in patients with a displaced FNF treated with a hemiarthroplasty or a total hip arthroplasty. Patients and methods — 292 patients (median age 83 (65–99) years, 68% female) with a displaced FNF were included in this prospective cohort study. To predict 1-year mortality, we used a multivariate logistic regression analysis including comorbidities and perioperative management. A receiver operating characteristic (ROC) analysis was used to evaluate the predictive ability of the Sernbo score, which was subsequently divided in a new manner into a low, intermediate, or high risk of death during the first year. Results — At 1-year follow-up, the overall mortality rate was 24%, and in Sernbo’s low-, intermediate-, and high-risk groups it was 5%, 22%, and 51%, respectively. The Sernbo score was the only statistically significant predictor of 1-year mortality: odds ratio for the intermediate-risk group was 4.2 (95% Cl: 1.5–12) and for the high-risk group it was 15 (95% CI: 5–40). The ROC analysis showed a fair predictive ability of the Sernbo score, with an area under the curve (AUC) of 0.79 (95% CI: 0.73–0.83). Using a cutoff of less than 11 points on the score gave a sensitivity of 61% and a specificity of 83%. Interpretation — The Sernbo score identifies patients who are at high risk of dying in the first postoperative year. This scoring system could be used to better tailor perioperative care and treatment in patients with displaced FNF.
Feasibility of outpatient total hip and knee arthroplasty in unselected patients
Creators: name: Gromov, Kirill
name: Kjærsgaard-Andersen, Per
name: Revald, Peter
name: Kehlet, Henrik
name: Husted, Henrik
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Background and purpose — The number of patients who are suitable for outpatient total hip and knee arthroplasty (THA and TKA) in an unselected patient population remains unknown. The purpose of this prospective 2-center study was to identify the number of patients suitable for outpatient THA and TKA in an unselected patient population, to investigate the proportion of patients who were discharged on the day of surgery (DOS), and to identify reasons for not being discharged on the DOS. Patients and methods — All consecutive, unselected patients who were referred to 2 participating centers and who were scheduled for primary THA and TKA were screened for eligibility for outpatient surgery with discharge to home on DOS. If patients did not fulfill the discharge criteria, the reasons preventing discharge were noted. Odds factors with relative risk intervals for not being discharged on DOS were identified while adjusting for age, sex, ASA score, BMI and distance to home. Results — Of the 557 patients who were referred to the participating surgeons during the study period, 54% were potentially eligible for outpatient surgery. Actual DOS discharge occurred in 13–15% of the 557 patients. Female sex and surgery late in the day increased the odds of not being discharged on the DOS. Interpretation — This study shows that even in unselected THA and TKA patients, same-day discharge is feasible in about 15% of patients. Future studies should evaluate safety aspects and economic benefits.
Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines
Creators: name: Moos, Lea M. Von
name: Schneider, Mirjam
name: Hilty, Florentine M.
name: Hilbe, Monika
name: Arnold, Myrtha
name: Ziegler, Nathalie
name: Mato, Diogo Sales
name: Winkler, Hans
name: Tarik, Mohamed
name: Ludwig, Christian
name: Naegeli, Hanspeter
name: Langhans, Wolfgang
name: Zimmermann, Michael B.
name: Sturla, Shana J.
name: Trantakis, Ioannis A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Nanotechnology offers new opportunities for providing health benefits in foods. Food fortification with iron phosphate nanoparticles (FePO4 NPs) is a promising new approach to reducing iron deficiency because FePO4 NPs combine high bioavailability with superior sensory performance in difficult to fortify foods. However, their safety remains largely untested. We fed rats for 90 days diets containing FePO4 NPs at doses at which iron sulfate (FeSO4), a commonly used food fortificant, has been shown to induce adverse effects. Feeding did not result in signs of toxicity, including oxidative stress, organ damage, excess iron accumulation in organs or histological changes. These safety data were corroborated by evidence that NPs were taken up by human gastrointestinal cell lines without reducing cell viability or inducing oxidative stress. Our findings suggest FePO4 NPs appear to be as safe for ingestion as FeSO4.
Airway Smooth Muscle Cells from Ovalbumin-Sensitized Mice Show Increased Proliferative Response to TGFβ1 due to Up-regulation of Smad3 and TGFβRII
Creators: name: Shi, Jianting
name: Chen, Ming
name: Ouyang, Lihua
name: Huang, Linjie
name: Lin, Xiaoling
name: Zhang, Wei
name: Liang, Ruiyun
name: Lv, Zhiqiang
name: Liu, Shanying
name: Jiang, Shanping
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Transforming growth factor (TGF)-β1 is an important cytokine in airway remodeling in asthma. However, results of studies focusing on the effect of TGFβ1 on proliferation of airway smooth muscle cells (ASMCs) are controversial. This study aimed to elucidate the role of TGFβ1 signaling in the proliferation of ASMCs by establishing an allergic model that mimics airway remodeling in chronic asthma and cell culture. Cell proliferation was detected by viable cell counting and Cell Counting Kit (CCK)-8 analysis. Expression and phosphorylation of Smad3, type 1 TGFβ receptor (TGFβRI), type 2 TGFβ receptor (TGFβRII), extracellular signal-regulated kinase (ERK)-1/2, p38 mitogen-activated protein kinase (MAPK), C-Jun N-terminal kinase (JNK) and AKT were detected by western blot. siRNAs were used to knock down Smad3 and TGFβRII. Smad3 and TGFβRII were up-regulated in primary ASMCs isolated from ovalbumin (OVA)-sensitized mice as compared with ASMCs isolated from unsensitized control mice, which persisted for at least four passages. TGFβ1 stimulated proliferation of ASMCs isolated from OVA-sensitized mice, which was inhibited by specific siRNA targeting Smad3 or TGFβRII. However ASMCs from control mice showed no proliferative response to TGFβ1. TGFβ1-induced proliferation of ASMCs from OVA-sensitized mice was markedly attenuated by PD-98059, a specific ERK1/2 inhibitor. TGFβ1 induced ERK1/2 phosphorylation within 15 minute, which was partially blocked by specific inhibitor of Smad3 (SIS3). ASMCs isolated from OVA-sensitized mice showed hyper-proliferation upon TGFβ1 stimulation. This might have been associated with up-regulated Smad3 and TGFβRII and mediated by ERK1/2 downstream to Smad3.
Figures with Multimedia Content from Form and function of the teleost lateral line revealed using three-dimensional imaging and computational fluid dynamics
Creators: name: Herzog, Hendrik
name: Klein, Birgit
name: Ziegler, Alexander
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 111602 Human Biophysics
subject: FOS: Basic medicine
subject: Computational Biology
subject: 80109 Pattern Recognition and Data Mining
subject: FOS: Computer and information sciences

description: Fishes sense weak water motion using the lateral line. Among the thousands of described fish species, this organ may differ in size, shape and distribution of individual mechanoreceptors or lateral line canals. The reasons for this diversity remain unclear, but are very likely related to habitat preferences. To better understand the performance of the organ in natural hydrodynamic surroundings, various three-dimensional imaging datasets of the cephalic lateral line were gathered using Leuciscus idus as representative freshwater teleost. These data are employed to simulate hydrodynamic phenomena around the head and within lateral line canals. The results show that changes in canal dimensions alter the absolute stimulation amplitudes, but have little effect on the relation between bulk water flow and higher frequency signals. By contrast, depressions in the skin known as epidermal pits reduce bulk flow stimulation and increase the ratio between higher-frequency signals and the background flow stimulus.
Extended Methods and Results from Form and function of the teleost lateral line revealed using three-dimensional imaging and computational fluid dynamics
Creators: name: Herzog, Hendrik
name: Klein, Birgit
name: Ziegler, Alexander
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 111602 Human Biophysics
subject: FOS: Basic medicine
subject: Computational Biology
subject: 80109 Pattern Recognition and Data Mining
subject: FOS: Computer and information sciences

description: Fishes sense weak water motion using the lateral line. Among the thousands of described fish species, this organ may differ in size, shape and distribution of individual mechanoreceptors or lateral line canals. The reasons for this diversity remain unclear, but are very likely related to habitat preferences. To better understand the performance of the organ in natural hydrodynamic surroundings, various three-dimensional imaging datasets of the cephalic lateral line were gathered using Leuciscus idus as representative freshwater teleost. These data are employed to simulate hydrodynamic phenomena around the head and within lateral line canals. The results show that changes in canal dimensions alter the absolute stimulation amplitudes, but have little effect on the relation between bulk water flow and higher frequency signals. By contrast, depressions in the skin known as epidermal pits reduce bulk flow stimulation and increase the ratio between higher-frequency signals and the background flow stimulus.
Additional file 1 of Decomposing intersectional inequalities in subjective physical and mental health by sex, gendered practices and immigration status in a representative panel study from Germany
Creators: name: Wandschneider, Lisa
name: Miani, Céline
name: Razum, Oliver
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1. Construction of the gender scores.
Additional file 2 of Decomposing intersectional inequalities in subjective physical and mental health by sex, gendered practices and immigration status in a representative panel study from Germany
Creators: name: Wandschneider, Lisa
name: Miani, Céline
name: Razum, Oliver
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 2. Descriptives of physical and mental health by intersectional groups.
Electrospun mupirocin loaded polyurethane fiber mats for anti-infection burn wound dressing application
Creators: name: Chen, Xinxin
name: Zhao, Rui
name: Wang, Xiang
name: Li, Xiang
name: Peng, Fei
name: Jin, Zhenghua
name: Gao, Xinxin
name: Yu, Jiaao
name: Wang, Ce
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Wound care treatment is a serious issue faced by the medical staffs due to its variety and complexity. Wound dressings are typically used to manage the various types of wounds. In this study, polyurethane (PU) fibers containing mupirocin (Mu), a commonly used antibiotic in wound care, were fabricated via electrospinning technique. The aim of this study was to develop biomedical electrospun fiber scaffolds for preventing wound infections with good compatibility and to demonstrate their applications as anti-infective burn wound dressings. The surface morphology of fibers was obtained by scanning electron microscopy. FT-IR spectra, water vapor transmission rate, and drug release study in vitro were tested to demonstrate the fiber scaffold characteristic. The prepared PU/Mu composite scaffolds had satisfactory antibacterial activity especially against Staphylococcus aureus. The cell studies revealed that the scaffolds were biocompatible and safe for cell attachment. Histological and immunohistochemical examinations were performed in rats, and the results indicated the histological analysis of tissue stained with H&E showed no obvious inflammation reaction. The results indicated that the electrospun scaffolds were capable of loading and delivering drugs, and could be potentially used as novel antibacterial burn wound dressings.
INVESTIGATION OF LONG TERM SAFE STORAGE OF CARBON DIOXIDE IN DEEP COAL SEAMS WITH ENHANCED METHANE RECOVERY
Creators: name: ASHANI SAVINDA RANATHUNGA
Publisher: name: Monash University
Year: 2017
Subjects: subject: 91402 Geomechanics and Resources Geotechnical Engineering
subject: FOS: Environmental engineering
subject: 40309 Petroleum and Coal Geology
subject: FOS: Earth and related environmental sciences

description: Carbon dioxide storage in deep coal seams is known as one of the promising methods to mitigate global warming. This method enhances the production of coal-bed methane, which is a greener energy source. However, this CO2 storage causes significant alterations in the coal chemico-physical structure, producing modifications to its hydro-mechanical properties. This results in a reduction of CO2 injectivity and methane production. Therefore, the aim of this thesis was to identify ideal injection strategies to find the optimum conditions to harvest methane from deep coal seams while storing maximum amounts of CO2 by conducting comprehensive multi-scale experimental and numerical studies.
Additional file 3 of Decomposing intersectional inequalities in subjective physical and mental health by sex, gendered practices and immigration status in a representative panel study from Germany
Creators: name: Wandschneider, Lisa
name: Miani, Céline
name: Razum, Oliver
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 3. Patterns of differences in physical and mental health by intersectional groups.
Insights into the structures, stabilities, electronic and magnetic properties of X2Aun (X = La, Y, and Sc; n = 1–9) clusters: comparison with pure gold clusters
Creators: name: Zhang, Hai-Rong
name: Zhao, Ya-Ru
name: Gao, Rui
name: Hu, Yan-Fei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Hematology

description: A systematic study of the X2Aun (X = La, Y, Sc; n = 1–9) clusters are performed by using the density functional theory at TPSS level. The structures, stabilities, electronic, and magnetic properties are investigated in comparison with pure gold clusters. The results show that the transition points of the doped clusters from two-dimensional to three-dimensional structure are obviously earlier than gold clusters. The impurity X atoms tend to occupy the most highly coordinated position and form the largest probable number of bonds with gold atoms. In addition, the impurity atoms can strongly enhance the stabilities of gold clusters. It indicates that the impurity atoms dramatically affect the geometries and stabilities of the Aun clusters. The highest occupied molecular orbital–lowest occupied molecular orbital gap, vertical ionisation potential, and chemical hardness show that the X2Au6 clusters have higher stabilities than the others. In La2Au1–9, Y2Au1–7, and Sc2Au1–4 clusters, the charges transfer from X atoms to the Aun frames. The total magnetic moments of X2Aun clusters exist distinctly odd–even alternation behaviours except for La2Au4 and Sc2Au4 clusters.
Additional file 1 of Translation of the geriatric emergency department intervention into other emergency departments: a post implementation evaluation of outcomes for older adults
Creators: name: Marsden, Elizabeth
name: Craswell, Alison
name: Taylor, Andrea
name: Barnett, Adrian
name: Wong, Pan-Kar
name: Wallis, Marianne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. STROBE Statement—Checklist of items that should be included in reports of cohort studies
Supplementary Material for: A Case of Adult Metastatic Rhabdomyosarcoma of the Prostate Cured by Long-Term Chemotherapy with Local Radiation
Creators: name: Konno, M.
name: Mitsuzuka, K.
name: Yamada, S.
name: Yamashita, S.
name: Kaiho, Y.
name: Ito, A.
name: Watanabe, M.
name: Arai, Y.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: A 32-year-old man visited our hospital due to urinary retention. Prostate-specific antigen was 13.7 ng/mL. Imaging examinations showed a large prostatic tumor and lung and internal iliac lymph node metastases. Transrectal biopsy confirmed embryonal rhabdomyosarcoma of the prostate classified as cT2bN1M1 (stage IV) by the International Rhabdomyosarcoma Study (IRS) Group staging system. Systemic chemotherapy was started according to the IRS III regimen 36, which consisted of 16 weeks of induction chemotherapy with radiation. After 20 weeks, magnetic resonance imaging showed the disappearance of metastases, and the prostate tumor shrunk markedly. Moreover, prostatic re-biopsy showed no viable tumor cells. Maintenance chemotherapy, excluding vincristine because of severe peripheral nerve disorder, was performed for 2 years. There has been no recurrence for 49 months after the termination of maintenance chemotherapy. To the best of our knowledge, this is the longest surviving case of adult-onset metastatic rhabdomyosarcoma of the prostate reported in the literature.
A multi-response multilevel model with application in nurse care coordination
Creators: name: Si, Bing
name: Lamb, Gerri
name: H. Schmitt, Madeline
name: Li, Jing
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Due to the aging of our society, patient care needs to be well coordinated within the health care team in order to effectively manage the overall health of each patient. Staff nurses, as the patient's “ever-present” health care team members, play a vital role in the care coordination. The recently developed Nurse Care Coordination Instrument (NCCI) is the first of its kind that enables quantitative data to be collected to measure various aspects of nurse care coordination. Driven by this new development, we propose a multi-response multilevel model with joint fixed effect selection and joint random effect selection across multiple responses. This model is particularly suitable for modeling the unique data structure of the NCCI due to its ability of jointly modeling of multilevel predictors, including demographic and workload variables at the individual/nurse level and characteristics of the practice environment at the unit level and multiple response variables that measure the key components of nurse care coordination. We develop a Block Coordinate Descent algorithm integrated with an Expectation-Maximization framework for model estimation. Asymptotic properties are derived. Finally, we present an application to a data set collected across four U.S. hospitals using the NCCI and discuss implications of the findings.
A Multi-response Multilevel Model with Application in Nurse Care Coordination
Creators: name: Si, Bing
name: Lamb, Gerri
name: Schmitt, Madeline
name: Li, Jing
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Due to the aging of our society, patient care needs to be well coordinated within the health care team in order to effectively manage the overall health of each patient. Staff nurses, as the patient's “ever-present” health care team members, play a vital role in the care coordination. The recently developed Nurse Care Coordination Instrument (NCCI) is the first of its kind that enables quantitative data to be collected to measure various aspects of nurse care coordination. Driven by this new development, we propose a multi-response multilevel model with joint fixed effect selection and joint random effect selection across multiple responses. This model is particularly suitable for modeling the unique data structure of the NCCI due to its ability of jointly modeling of multilevel predictors, including demographic and workload variables at the individual/nurse level and characteristics of the practice environment at the unit level, and multiple response variables that measure the key components of nurse care coordination. We develop a Block Coordinate Descent algorithm integrated with an Expectation-Maximization framework for model estimation. Asymptotic properties are derived. Finally, we present an application to a dataset collected across four U.S. hospitals using the NCCI and discuss implications of the findings.
Supplementary Material for: Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy
Creators: name: Park, H.-K.
name: Chung, J.-W.
name: Hong, J.-H.
name: Jang, M.U.
name: Noh, H.-D.
name: Park, J.-M.
name: Kang, K.
name: Lee, S.J.
name: Ko, Y.
name: Kim, J.G.
name: Cha, J.-K.
name: Kim, D.-H.
name: Nah, H.-W.
name: Han, M.-K.
name: Kim, B.J.
name: Park, T.H.
name: Park, S.-S.
name: Lee, K.B.
name: Lee, J.
name: Hong, K.-S.
name: Cho, Y.-J.
name: Lee, B.-C.
name: Yu, K.-H.
name: Oh, M.S.
name: Cho, K.-H.
name: Kim, J.-T.
name: Kim, D.-E.
name: Ryu, W.-S.
name: Choi, J.C.
name: Kim, W.-J.
name: Shin, D.-I.
name: Yeo, M.-J.
name: Sohn, S.-I.
name: Lee, J.S.
name: Yoon, B.-W.
name: Bae, H.-J.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 ± 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months.
Supplementary Material for: Predictive Validity of Two Physical Frailty Phenotype Specifications Developed for Investigation of Frailty Pathways in Older People
Creators: name: Ding, Y.Y.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: For investigating the relationship of frailty with physical, psychological, and social conditions on pathways, the frailty definition should ideally exclude these conditions. Based on the frailty phenotype, 2 candidate physical frailty specifications or instruments with 3 indicators, namely slowness, weakness, and exhaustion, and 4 indicators with addition of weight loss were previously developed, and had their construct and concurrent validity demonstrated. Objective: This study seeks to evaluate the predictive validity of 2 candidate physical frailty specifications with respect to death, functional impairment, and poor quality of life in older people. Methods: For 4,368 respondents aged 65-89 years from wave 2 of the English Longitudinal Study of Ageing, confirmatory factor analysis is performed for these 2 physical frailty specifications to obtain unique factor scores for each respondent. Prediction of death, basic and instrumental activities of daily living (BADL and IADL) difficulty, and poor quality of life (reverse of Control, Autonomy, Self-realization, and Pleasure [19 items] or CASP-19) 2 years later by factor scores for these 2 specifications is evaluated using standardized coefficients, c-statistics, and r2 values from regression analyses. Their performance is compared with those of alternative specifications with 3 (slowness, weakness, and weight loss) and 5 indicators (slowness, weakness, exhaustion, weight loss, and low physical activity), and Frailty Index (FI). Results: For the 2 candidate specifications, an increase of 1 standard deviation (SD) predicts 50-57% increase in odds of death, 0.10-15 SD increase in change in BADL or IADL difficulty, and poor quality of life at 2 years. They predict these outcomes as well or better than the alternative specification with 3 indicators, but marginally worse than that with 5 indicators. Compared with FI, they predict death and poor quality of life similarly, but perform worse for functional impairment. Minor differences are observed across gender. Conclusion: Reasonable predictive validity of 2 candidate physical frailty specifications based on the frailty phenotype with 3 and 4 indicators is demonstrated for death, functional impairment, and poor quality of life. These findings offer evidence to support their suitability for employment in investigating frailty pathways in older people.
Additional file 1 of HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy
Creators: name: Hussain, Khiyam
name: Liu, Rena
name: Smith, Rosanna C. G.
name: Müller, Kri T. J.
name: Ghorbani, Mohammadmersad
name: Macari, Sofia
name: Cleary, Kirstie L. S.
name: Oldham, Robert J.
name: Foxall, Russell B.
name: James, Sonya
name: Booth, Steven G.
name: Murray, Tom
name: Dahal, Lekh N.
name: Hargreaves, Chantal E.
name: Kemp, Robert S.
name: Longley, Jemma
name: Douglas, James
name: Markham, Hannah
name: Chee, Serena J.
name: Stopforth, Richard J.
name: Roghanian, Ali
name: Carter, Matthew J.
name: Ottensmeier, Christian H.
name: Frendéus, Bjorn
name: Cutress, Ramsey I.
name: French, Ruth R.
name: Glennie, Martin J.
name: Strefford, Jonathan C.
name: Thirdborough, Stephen M.
name: Beers, Stephen A.
name: Cragg, Mark S.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1:
Characteristics of DO, organic matter, and ammonium profile for practical-scale DHS reactor under various organic load and temperature conditions
Creators: name: Nomoto, Naoki
name: Muntjeer Ali
name: Komal Jayaswal
name: Iguchi, Akinori
name: Hatamoto, Masashi
name: Okubo, Tsutomu
name: Takahashi, Masanobu
name: Kubota, Kengo
name: Tagawa, Tadashi
name: Uemura, Shigeki
name: Yamaguchi, Takashi
name: Harada, Hideki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Profile analysis of the down-flow hanging sponge (DHS) reactor was conducted under various temperature and organic load conditions to understand the organic removal and nitrification process for sewage treatment. Under high organic load conditions (3.21–7.89 kg-COD m−3 day−1), dissolved oxygen (DO) on the upper layer of the reactor was affected by organic matter concentration and water temperature, and sometimes reaches around zero. Almost half of the CODCr was removed by the first layer, which could be attributed to the adsorption of organic matter on sponge media. After the first layer, organic removal proceeded along the first-order reaction equation from the second to the fourth layers. The ammoniacal nitrogen removal ratio decreased under high organic matter concentration (above 100 mg L−1) and low DO (less than 1 mg L−1) condition. Ammoniacal nitrogen removal proceeded via a zero-order reaction equation along the reactor height. In addition, the profile results of DO, CODCr, and NH3-N were different in the horizontal direction. Thus, it is thought the concentration of these items and microbial activities were not in a uniform state even in the same sponge layer of the DHS reactor.
Integration of microRNA, mRNA and protein expression data for the identification of cancer-related microRNA
Creators: name: Seo, Ji Youn
name: Jin, Daeyong
name: Choi, Chan-Hun
name: Lee, Hyunju
Publisher: name: figshare
Year: 2016
Subjects: classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified

description: Instructions for running source codes are here.
e-BioSign-DS1-Signature DB
Creators: name: Tolosana, Ruben
name: Vera-Rodriguez, Ruben
name: Fierrez, Julian
name: Aythami Morales
name: Ortega-Garcia, Javier
Publisher: name: figshare
Year: 2017
Subjects: subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: DESCRIPTION OF e-BioSign-DS1-Signature DBThe dataset comprises on-line signatures acquired from 5 different COTS devices in total, three Wacom devices (STU-500, STU-530 and DTU-1031) specifically designed to capture dynamic signatures and handwritng, and two Samsung general purpose tablets (Samsung Galaxy Note 10.1 and Samsung ATIV 7). For the two Samsung tablets, data is collected using both pen stylus and also the finger. Data was collected in two sessions for 65 subjects. Skilled forgeries were also performed. In Fig. 1 the description of the devices and the acquisition setup per device and user considered in the e-BioSign database are depicted. We report in [PONE2017] a benchmark performance based on e-BioSign for person verification under three different real scenarios: 1) intra-device scenario, 2) inter-device scenario, and 3) mixed writing-tool scenario. We have also experimented the proposed benchmark using the main existing approaches for signature verification: feature- and time functions-based.
REFERENCESFor further information on the database and on different applications where it has been used, we refer the reader to:[PONE2017] R. Tolosana, R. Vera-Rodriguez, J. Fierrez, A. Morales and J. Ortega-Garcia, "Benchmarking Desktop and Mobile Handwriting across COTS Devices: the e-BioSign Biometric Database.", PLOS ONE, 2017.

INSTRUCTIONS FOR DOWNLOADING e-BioSign-DS1-Signature DB
1. Download the license agreement, send by email one signed and scanned copy to atvs@uam.es according to the instructions given in point 2.2. Send an email to atvs@uam.es, as follows:
Subject: [DATABASE download: e-BioSign-DS1-Signature DB]

Body: Your name, e-mail, telephone number, organization, postal mail, purpose for which you will use the database, time and date at which you sent the email with the signed license agreement.
3. Once the email copy of the license agreement has been received at ATVS, you will receive an email with the figshare link, and a time slot to download the database.
4. Download the database, for which you will need to provide the authentication information given in step 3. After you finish the download, please notify by email to atvs@uam.es that you have successfully completed the transaction.5. For more information, please contact: atvs@uam.es
ADDITIONAL INFORMATION
https://atvs.ii.uam.es/atvs/eBioSign-DS1.html
Carnet nº 22, commencé à Haiphong (p. 17)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 16-8-1931
EZH2 inhibitors: a patent review (2014-2016)
Creators: name: Stazi, Giulia
name: Zwergel, Clemens
name: Mai, Antonello
name: Valente, Sergio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Introduction: The histone methyltransferase EZH2 is the catalytic subunit of the PRC2 complex involved in H3K27 trimethylation. Aberrant PRC2 activity has been reported in several cancers and EZH2 overexpression has been associated with poor outcome in different tumors. EZH2 somatic mutations and deletions was found in lymphomas, myelodysplastic and myeloproliferative disorders and associated with higher H3K27me3 levels. Numerous chemical entities have been studied as EZH2 inhibitors in the recent years and some of them entered the cancer clinical arena. Areas covered: This review summarizes recent efforts in the drug development of EZH2 inhibitors reported in the patent literature covering the 2014–2016 period, and their potential use as therapeutics mainly in cancerous diseases. Expert opinion: Despite the number of compounds described, only a few of them entered the clinical arena. Moreover, most of the compounds developed share a common 2-pyridone ring pharmacophore. Recently, secondary mutants have been described to be resistant to the standard EZH2 inhibitors treatment. Based on these data a lot of effort is still required to find new chemical entities that inhibit EZH2 directly, or indirectly (via PRC2 disruption). Several issues are still to be settled, such as drug resistance and the importance of selectivity over EZH1 or somatic EZH2 mutants.
ARTIFICIAL INTELLIGENCE-BASED MODELING: AUTOMATION, INTELLIGENT SYSTEMS, APPLICATIONS, AND RESEARCH.
Creators: name: Saidov, Umedjon
Publisher: name: Zenodo
Year: 2024

description: Artificial intelligence has completely changed the way we live with innovative technologies. Artificial intelligence has entered human life very quickly and has made incredible changes, taking its toll on every area of society. The term artificial intelligence was first introduced at a conference in 1956[1]. The discussion at the conference led to the natural language generation of interdisciplinary information technology. The emergence of the internet contributed to the rapid development of technology. Artificial intelligence technology has been an independent technology for thirty years, but now this technology has become widespread in all spheres of life. Artificial intelligence is known by the acronym AI and is the process of recreating human intelligence in machines.
Additional file 2 of A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types
Creators: name: Gather, Fabian
name: Ihrig-Biedert, Irmgard
name: Kohlhas, Paul
name: Krutenko, Tamara
name: Peitz, Michael
name: Brüstle, Oliver
name: Pautz, Andrea
name: Kleinert, Hartmut
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1. Supplementary Data.
In the electronic supplementary material, Figure S1–S5 are included. from Halloysite nanotube-based electrospun ceramic nanofibre mat: a novel support for zeolite membranes
Creators: name: Chen, Zhuwen
name: Zeng, Jiaying
name: Lv, Dong
name: Gao, Jinqiang
name: Zhang, Jian
name: Bai, Shan
name: Li, Ruili
name: Hong, Mei
name: Wu, Jingshen
Publisher: name: The Royal Society
Year: 2016

description: Some key parameters of supports such as porosity, pore shape and size are of great importance for fabrication and performance of zeolite membranes. In this study, we fabricated millimetre-thick, self-standing electrospun ceramic nanofibre mats and employed them as a novel support for zeolite membranes. The nanofibre mats were prepared by electrospinning a halloysite nanotubes/polyvinyl pyrrolidone composite followed by a programmed sintering process. The interwoven nanofibre mats possess up to 80% porosity, narrow pore size distribution, low pore tortuosity and highly interconnected pore structure. Compared with the commercial α-Al2O3 supports prepared by powder compaction and sintering, the halloysite nanotube-based mats (HNMs) show higher flux, better adsorption of zeolite seeds, adhesion of zeolite membranes and lower Al leaching. Four types of zeolite membranes supported on HNMs have been successfully synthesized with either in situ crystallization or a secondary growth method, demonstrating good universality of HNMs for supporting zeolite membranes.
Additional file 1 of Shift-work and breastfeeding for women returning to work in a manufacturing workplace in Taiwan
Creators: name: Tsai, Su-Ying
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Associationbetween continued breastfeeding behavior and associated factors among employed motherswith and without shift work.
Additional file 1 of Analysis of the association between areal socioeconomic deprivation levels and viral hepatitis B and C infections in Japanese municipalities
Creators: name: Okui, Tasuku
name: Nakashima, Naoki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. A base map of Japan with prefectural name
title: Plano de Ações Estratégicas no Semiárido Brasileiro - com foco na Bacia do Rio São Francisco e Área de Transposição
title: Ações estratégicas no Semiárido Brasileiro - com foco na Bacia do Rio São Francisco e Área de Transposição resultantes do Processo Participativo Multiescala 3H-ODS
titleType: Subtitle
Creators: name: Sonetti González, Taís
name: Aguiar, Ana Paula
name: Silva Bezerra, Francisco Gilney
name: Alves Martins, Minella
name: Perez-Marin, Aldrin Martin
name: Silva, Alineaurea
name: Lima Peres, Berenice
name: Cruz Cardoso, Detina
name: C. Henn Souza de Oliveira, Fernanda
name: de Aquino, Francisco Ivan
name: de Souza Corte, Ivanildo
name: Santos, Jean Carlos
name: Gnadlinger, Johann
name: da Silva Neto, João Pedro
name: Ferreira da Silva, Luciana
name: Ayres da Motta Benevides Gadelha, Maysa
name: SALES, RICELIA MARIA MARINHO
name: da Silva Andrade, Sandra Maria
name: Rodrigues de Moraes, Silvanda
name: Martins de Oliveira, Vanúbia
Publisher: name: Zenodo
Year: 2024

description: O documento apresenta uma síntese dos resultados obtidos pelos projetos NEXUS e XPaths, os quais se dedicam a explorar futuros sustentáveis em consonância com os 17 Objetivos do Desenvolvimento Sustentável (ODS) estabelecidos pela ONU para 2030. Este destaca a importância da colaboração entre multi-atores e em multi-escalas como um elemento-chave para promover avanços em direção aos ODS, evidenciando o potencial dos diálogos participativos na elaboração de estratégias para enfrentar desafios socioambientais.

Dentro do contexto da Bacia Hidrográfica do Rio São Francisco, esses atores identificaram quatro problemas principais e delinearam ações estratégicas correspondentes com o objetivo de alcançar sustentabilidade e justiça. Esses esforços demonstram um compromisso com abordagens integradas e participativas para lidar com questões complexas e interconectadas relacionadas ao desenvolvimento sustentável.

Os projetos XPaths e NEXUS colaboraram de maneira significativa, destacando a importância da cooperação interdisciplinar para promover a sustentabilidade. Em suma, o documento enfatiza a colaboração multissetorial e entre múltiplos atores como fundamental para avançar nos ODS, ilustrando o potencial dos diálogos participativos na elaboração de estratégias para enfrentar os desafios socioambientais emergentes.
Additional file 1 of Novel allyl-hydrazones including 2,4-dinitrophenyl and 1,2,3-triazole moieties as optical sensor for ammonia and chromium ions in water
Creators: name: Mohamed, Hanan A.
name: Abdel-Wahab, Bakr F.
name: Yousif, Mahmoud N. M.
name: Abdelhameed, Reda M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 1: Figure S1. [a] Change of ammonia absorbance for compound 4b with different concentration; [b] linear fitting. Figure S2. [a] Change of chromium absorbance for compound 4b with different concentration; [b] linear fitting. Figure S3. NMR spectrum (13C NMR) for compound 3a. Figure S4. NMR spectrum (1H NMR) for compound 3a. Figure S5. NMR spectrum (13C NMR) for compound 3b. Figure S6. NMR spectrum (1H NMR) for compound 3b. Figure S7. NMR spectrum (13C NMR) for compound 4a. Figure S8. NMR spectrum (1H NMR) for compound 4a. Figure S9. NMR spectrum (13C NMR) for compound 4b. Figure S10. NMR spectrum (1H NMR) for compound 4b. Figure S11. NMR spectrum (1H NMR) for compound 4b in D2O. Figure S12. FTIR spectrum for compound 4a. Figure S12. FTIR spectrum for compound 4b.
Estimating Production Function for Farm Crops of Iran as a Dependent of Machinery Input Indicators, Approaching System Dynamics Methodologyitem
Creators: name: Jalalzadeh, Behnam
name: Borghei, Ali Mohammad
name: Almassi, Morteza
Publisher: name: figshare
Year: 2017
Subjects: subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: 140201 Agricultural Economics
subject: FOS: Economics and business

description: Estimating Production Function for Farm Crops of Iran as a Dependent of Machinery Input Indicators, Approaching System Dynamics Methodology
Preparation, characterization and in vitro anticoagulant activity of corn stover xylan sulfates
Creators: name: Cheng, He-Li
name: Liu, Hao
name: Feng, Qing-Hua
name: Xie, Yi-Min
name: Zhan, Huai-Yu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Hematology
subject: Plant Biology

description: A new anticoagulant agent was prepared by introducing sulfate groups into corn stover xylan through homogeneous reactions. Three organic solvents, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and formamide (FA), were adopted as reaction media, with the assistance of LiCl. Structural characterization by FT-IR and 13CNMR showed that xylan sulfate (XS) could be successfully synthesized with SO3∙Pyridine (SO3∙Py) complexes sulfation reagent in the three media. The effect of sulfation temperature, sulfation time, media type and molar ratio of −SO3/−OH on the degree of substitution (DS) and degree of the polymerization (DP) were studied. DMF/LiCl were more effective than DMSO/LiCl and FA/LiCl in preparation of xylan sulfate with high DS. The optimal conditions for sulfation were obtained when SO3∙Py complex was added to DMF/LiCl with −SO3/−OH ratio of 1.5:1 and maintained at 50 °C for 3 h. Degree of polymerization of xylan was decreased during the sulfation process and DMF/LiCl offered the least xylan degradation as compared with DMSO/LiCl or FA/LiCl. Anticoagulant activities of the resultant xylan sulfates with different DS were evaluated by using activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). Results indicated that the introducing of sulfate groups into xylan did endow the polysaccharides with anticoagulant activity. The APTT and TT of XS with DS of 1.20 reached 141 and 45.3 s at a dosage of 20 μg/mL, while the APTT and TT values for the blank sample were only 35.5 and 15.6 s. Furthermore, coagulation time was prolonged with the increase of DS and the concentration of XS. Our findings provide new insights into the value-added utilization of agricultural biomass.