cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The cost-effectiveness of dacomitinib in first-line treatment of advanced/metastatic epidermal growth factor receptor mutation-positive non-small-cell lung cancer (EGFRm NSCLC) in Sweden
Creators: name: Nilsson, Fredrik O. L.
name: Gal, Peter
name: Houisse, Ivan
name: Ivanova, Jasmina I.
name: Asanin, Sandra T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) over chemotherapy in EGFR mutation-positive (EGFRm) non-small-cell lung cancer (NSCLC) has been demonstrated in clinical trials, the optimal treatment sequence remains unclear. The objective of our study was to evaluate the cost-effectiveness of dacomitinib in Sweden vs afatinib and osimertinib in first-line treatment of EGFRm NSCLC. A partitioned survival model was developed with three health states: progression-free, post-progression, and death. Progression-free and overall survival curves were used to inform movements between states. Clinical data were taken from randomized trials, compared via a network meta-analysis (NMA). Utility data were taken from published studies and costs from national Swedish sources. The model used a 15-year time horizon and a Swedish healthcare payer perspective. Sensitivity and scenario analyses were performed. The base-case analysis showed that dacomitinib accrued a total of 2.10 quality-adjusted life-years (QALYs) at a total cost of Swedish krona (SEK) 874,615. The incremental cost-effectiveness ratio (ICER) for dacomitinib vs afatinib was SEK 461,556 per QALY gained. The ICER of osimertinib vs dacomitinib, where the small QALY gains of the former came at a high additional cost, was SEK 11,444,709. Deterministic and probabilistic sensitivity analyses confirmed the robustness of these results; changes to drug and medical resource use costs and overall survival had the greatest impact on ICER estimates. This model is subject to uncertainty associated with extrapolating long-term treatment effects from shorter trial follow-up periods, although this would also be a limitation when using direct comparison or time-dependent hazard ratios. The NMA was limited by the use of indirect comparison, although sensitivity analyses supported the robustness of our findings. Our model demonstrated that dacomitinib is cost-effective for first-line EGFRm NSCLC treatment in Sweden vs afatinib and osimertinib.
Ψηλαφώντας την αίσθηση της ασφάλειας και χαρακτηριστικά αντι-κοινού (counterpublic) σε μία διαδικτυακή φεμινιστική σελίδα: Το παράδειγμα της σελίδας «Φεμινιστικά Παραληρήματα»
Creators: name: Μοτσιοπούλου, Αθηνά Χρήστου
Publisher: name: Aristotle University of Thessaloniki
Year: 2021
Subjects: Διαδικτυακός φεμινισμός
Ασφαλής χώρος
Αντι-κοινό
Online feminism
Safe space
Counterpublic

description: Η παρούσα εργασία επιχειρεί να διερευνήσει τις νοηματοδοτήσεις που αποκτά η διαδικτυακή φεμινιστική σελίδα ονόματι «Φεμινιστικά Παραληρήματα». Τα «Φεμινιστικά Παραληρήματα» αποτελούν μία σελίδα στην πλατφόρμα του facebook, όπου τα μέλη στέλνουν προς δημοσίευση ιστορίες, βιώματα, σκέψεις ή προβληματισμούς που σχετίζονται με το φεμινισμό και το σεξισμό. Αντλώντας από τις έννοιες του ασφαλούς χώρου (safe space) και του υπεξούσιου αντι-κοινού (subaltern counterpublic), η εργασία αποπειράται να ψηλαφήσει την αίσθηση της ασφάλειας εντός της σελίδας, όπως και το αν παρουσιάζει χαρακτηριστικά αντι-κοινού. Επομένως η μελέτη ενδιαφέρεται α) για τη διερεύνηση της πρόσληψής των «Φεμινιστικών Παραληρημάτων» ως ασφαλούς χώρου (safe space) και β) για τη διερεύνηση της πρόσληψής της σελίδας ως αντι-κοινού (counterpublic) με βάση τις εμπειρίες ατόμων που αποτελούν ενεργά μέλη της. Με άλλα λόγια, εκκινώντας από την Kριτική φεμινιστική προσέγγιση αναρωτιόμαστε αν ο χώρος των «Φεμινιστικών Παραληρημάτων» αποτελεί ένα πεδίο αμφισβήτησης και αντίστασης στις κυρίαρχες εξουσιαστικές πατριαρχικές πρακτικές και σχέσεις. Παρά το έντονο ενδιαφέρον που έχει αναπτυχθεί ακαδημαϊκά γύρω από τις διαδικτυακές φεμινιστικές σελίδες, η εγχώρια βιβλιογραφία στο συγκεκριμένο ζήτημα δεν είναι εκτενώς ανεπτυγμένη. Επομένως, η παρούσα εργασία ευελπιστεί να εμπλουτίζει το παρόν θεωρητικό πεδίο.
description: The paper attempts to investigate the meanings of the feminist online site called “Feministika Paralirimata” which is present on the facebook platform. “Feministika Paralirimata” is a public page on Facebook, where its members send stories, experiences, thoughts, or concerns related to feminism and sexism to be published. Drawing on the concepts of safe space and subaltern counterpublic, the author tries to map the sense of safety within the page, as well as to examine if characteristics of a counterpublic space can emerge in the case of “Feministika paralirimata”. Therefore, there is an interest in investigating if the page’s members perceive it a) as a safe space and b) as a counterpublic. In other words, setting the critical feminist approach as a starting point, we wonder if the space of "Feministika Paralirimata" is a field of questioning and resistance to the dominant authoritarian patriarchal practices and relations. Despite the intense academic research in feminist web pages, the domestic literature on the subject is not extensively developed. Therefore, the present work hopes to enrich the given theoretical field.
title: The role of knowledge and research in two case studies on cross-borderMaritime Spatial Planning in the southern North Sea
Creators: name: Hommes, S.
name: Pastoors, M. A.
name: Stelzenmüller, V.
name: Goldsborough, D.
name: Sørensen, F. Maes T. K.
name: Stuiver, M.
name: de Vos, B.
Publisher: name: ASC 2012 - Theme session I
Year: 2024
Subjects: Fisheries and aquaculture

description: No abstracts are to be cited without prior reference to the author.Maritime Spatial Planning (MSP) is worldwide advocated as a promising tool for implementing ecosystem based maritime spatial management, which should resolve inter-sectoral and cross-border conflicts over maritime space (Ehler, 2008; Halpern et al., 2008; Douvere, 2010). Foley et al. (2010) defined ecosystem based MSP as an integrated planning framework that informs the spatial distribution of activities in and on the ocean in order to support current and future uses of ocean ecosystems and maintain the delivery of valuable ecosystem services for future generations in a way that meets ecological, economic and social objectives. In Europe, most ecosystem based sea use management and MSP initiatives are driven by international and European legislation such as the European Commissions Green Paper on Maritime Policy (Douvere and Ehler, 2008). Further, the recent EU Communication on MSP (EC, 2008) considers MSP as a key instrument for the application of the European Integrated Maritime Policy and lays out guiding principles encouraging the development of a common approach among member states. As yet, most MSP initiatives are confined within national boundaries and account only for local habitats and ecosystems while ignoring potential transboundary impacts of human uses such as shipping or fisheries (Maes, 2008; Douvere and Ehler, 2008).
Magnetic, thermal and rotational evolution of isolated neutron stars
Creators: name: Pons, José A.
name: Viganò, Daniele
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The strong magnetic field of neutron stars is intimately coupled to the observed temperature and spectral properties, as well as to the observed timing properties (distribution of spin periods and period derivatives). Thus, a proper theoretical and numerical study of the magnetic field evolution equations, supplemented with detailed calculations of microphysical properties (heat and electrical conductivity, neutrino emission rates) is crucial to understand how the strength and topology of the magnetic field vary as a function of age, which in turn is the key to decipher the physical processes behind the varied neutron star phenomenology. In this review, we go through the basic theory describing the magneto-thermal evolution models of neutron stars, focusing on numerical techniques, and providing a battery of benchmark tests to be used as a reference for present and future code developments. We summarize well-known results from axisymmetric cases, give a new look at the latest 3D advances, and present an overview of the expectations for the field in the coming years.
description: Accepted for Living Reviews in Computational Astrophysics. 64 pages, 20 figures
Figure 5. Dissolution pattern for the flow rate 100 ml/h in horizontal (BH100) (top) and vertical (BV100) (bottom) configurations. Left – Grayscale image at breakthrough, the red line represents the interface between dissolved area and non-dissolved area as obtained from the segmentation. Blue rectangle locates the zoomed area. Right – Recolored zoomed images of dissolution at different times relative to the initial image
Creators: name: Assohoun Wilfried Arnaud Ahoulou
Publisher: name: figshare
Year: 2020
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: 40403 Geophysical Fluid Dynamics
subject: 40603 Hydrogeology
subject: Solid Earth Sciences

description: Dissolution pattern for the flow rate 100 ml/h in horizontal and vertical configurations
Berta Karlik -- The Grande Dame of the Vienna Radium Institute
Creators: name: Strohmaier, Brigitte
Publisher: name: arXiv
Year: 2024
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: Berta Karlik was an Austrian physicist who was not only among the early radioactivity researchers and nuclear physicists in Vienna, but also pioneered a woman's academic career in Austria. She was the first woman at the University of Vienna to acquire the venia legendi in physics, and the first full professor at a philosophical faculty in Austria. For almost thirty years she was the head of the Institute for Radium Research of the Austrian Academy of Sciences.
description: 12 pages, 5 figures
Normalized Gaussian Path Integrals
Creators: name: Corazza, Giulio
name: Fadel, Matteo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Path integrals play a crucial role in describing the dynamics of physical systems subject to classical or quantum noise. In fact, when correctly normalized, they express the probability of transition between two states of the system. In this work, we show a consistent approach to solve conditional and unconditional Euclidean (Wiener) Gaussian path integrals that allow us to compute transition probabilities in the semi-classical approximation from the solutions of a system of linear differential equations. Our method is particularly useful for investigating Fokker-Planck dynamics, and the physics of string-like objects such as polymers. To give some examples, we derive the time evolution of the d-dimensional Ornstein-Uhlenbeck process, and of the Van der Pol oscillator driven by white noise. Moreover, we compute the end-to-end transition probability for a charged string at thermal equilibrium, when an external field is applied.
description: 15 pages (7 of appendices), one figure
Voice Packet Performance Estimation through Step Network Using OPNET
Creators: name: Zaidi, Taskeen
name: Dwivedi, Nitya Nand
Publisher: name: arXiv
Year: 2019
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: VoIP transfer voice over networks such as LAN. This technology is growing rapidly due to support of existing network infrastructure at low cost. Various simulations have been done and it is observed that by increasing the VoIP client, packet length and traffic arrival rate the performance of step network affected. In the current work packet dropped, packet received, voice traffic sent and end-to-end delay is estimated for various queuing disciplines like PQ, FIFO and WFQ. It is depicted that queuing disciplines effects the applications performance and utilization of resources.
description: 2018 IEEE 3rd International Conference on Computing, Communication and Security (ICCCS). arXiv admin note: text overlap with arXiv:1701.04792
Integrable Lattice Models for Conjugate $A^{(1)}_n$
Creators: name: Behrend, Roger E.
name: Evans, David E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: A new class of $A^{(1)}_n$ integrable lattice models is presented. These are interaction-round-a-face models based on fundamental nimrep graphs associated with the $A^{(1)}_n$ conjugate modular invariants, there being a model for each value of the rank and level. The Boltzmann weights are parameterized by elliptic theta functions and satisfy the Yang-Baxter equation for any fixed value of the elliptic nome q. At q=0, the models provide representations of the Hecke algebra and are expected to lead in the continuum limit to coset conformal field theories related to the $A^{(1)}_n$ conjugate modular invariants.
description: 18 pages. v2: minor changes, such as page 11 footnote
Cosmological implications of a modified galaxy cluster pressure profile using the $Planck$ tSZ power spectrum
Creators: name: Ruppin, F.
name: Mayet, F.
name: Macías-Pérez, J. F.
name: Perotto, L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The mean pressure profile of the cluster population is a key element in cosmological analyses based on surveys of galaxy clusters observed through the Sunyaev-Zel'dovich (SZ) effect. A variation of both the shape and the amplitude of this profile could explain part of the discrepancy currently observed between the cosmological constraints obtained from the analyses of the CMB primary anisotropies and those from cluster abundance in SZ surveys for a fixed mass bias parameter. We study the cosmological implications of a modification of the mean pressure profile through the analysis of the SZ power spectrum measured by $Planck$. We define two mean pressure profiles on either side of the one obtained from the observation of nearby clusters by $Planck$. The parameters of these profiles are chosen to ensure their compatibility with the distributions of pressure and gas mass fraction profiles observed at low redshift. We find significant differences between the cosmological parameters obtained by using these two profiles to fit the $Planck$ SZ power spectrum and those found in previous analyses. We conclude that a ${\sim}15\%$ decrease of the amplitude of the mean normalized pressure profile is sufficient to alleviate the discrepancy observed between the constraints of $σ_8$ and $Ω_m$ from the CMB and cluster analyses.
description: to appear in the proceedings of the international conference entitled mm Universe @ NIKA2, Grenoble (France), June 2019, EPJ Web of conferences
Υγιεινή και ασφάλεια στα νοσοκομεία με αναφορά στο Covid-19
Creators: name: Παπαδοπούλου, Βασιλική Κωνσταντίνου
Publisher: name: Aristotle University of Thessaloniki
Year: 2021
Subjects: Ασφάλεια
Νοσοκομεία
Κορωνοιός
Safety
Hospitals
Covid-19

description: Η υγιεινή και ασφάλεια στα νοσοκομεία αποτελεί ένα θέμα που απασχολεί ιδιαίτερα κατά την πανδημία του κορωνοϊού, η οποία δοκιμάζει το σύστημα υγείας. Η πνευμονία του κορωνοϊού κατατάσσεται στη πέμπτη κατηγορία νόμιμων μολυσματικών ασθενειών και χαρακτηρίστηκε ως σοβαρή ειδική μολυσματική πνευμονία. Ακόμη, σύμφωνα με την ανάλυση κινδύνων επιβεβαιώνεται ότι το ιατρικό/νοσηλευτικό προσωπικό αντιπροσωπεύει μια ομάδα υψηλού κινδύνου για λοίμωξη από SARS-CoV-2 και ότι υπάρχουν κενά στον έλεγχο των λοιμώξεων σε νοσοκομεία, ενώ καθίστανται σαφές ότι τα μέτρα προστασίας και αντιμετώπισης της πανδημίας δεν ήταν επαρκή. Περαιτέρω μέτρα είναι αναγκαίο να ληφθούν στα νοσοκομεία ώστε να μην χάνονται ζωές, οι οποίες αν δεν υπήρχε πανδημία θα μπορούσαν να είχαν σωθεί. Προκειμένου να διερευνηθεί η υγιεινή και ασφάλεια στα νοσοκομεία με αναφορά στον Covid-19, δημιουργήθηκε, μοιράστηκε και αναλύθηκε ερωτηματολόγιο με 27 ερωτήσεις που απαντήθηκε από τα 102 άτομα, διαφορετικού φύλου, ηλικίας, επίπεδου εκπαίδευσης και επαγγέλματος, ενώ λίγο περισσότεροι από τους μισούς ήταν άντρες και οι υπόλοιπες γυναίκες.
description: Hygiene and safety in hospitals is an issue of particular concern during the coronavirus pandemic, which is testing the health system. Coronavirus pneumonia is classified in the fifth category of legal infectious diseases and has been classified as a severe specific infectious pneumonia. Furthermore, the risk analysis confirms that medical/nursing staff represent a high-risk group for SARS-CoV-2 infection and that there are gaps in infection control in hospitals, while it becomes clear that protection and response measures to the pandemic were inadequate. Further measures need to be taken in hospitals to prevent the loss of lives that could have been saved in the absence of the pandemic. In order to investigate hygiene and safety in hospitals with reference to Covid-19, a questionnaire with 27 questions was created, distributed and analysed and answered by the 102 people, of different gender, age, level of education and occupation, with slightly more than half being men and the rest women.
title: Representation of the use of marine space by commercial fisheries in Marine Spatial Planning
Creators: name: Kafas, Andronikos
name: Jones, Gareth
name: Watret, Robert
name: Davies, Ian
name: Scott, Beth
Publisher: name: ASC 2012 - Theme session I
Year: 2024
Subjects: Fisheries and aquaculture

description: No abstracts are to be cited without prior reference to the author.Successful marine spatial planning requires that the underlying data and process of marine activities can gain the confidence of a wide range of stakeholders. Fishers are major users of our seas, and therefore are of particular importance in marine planning consideration. Appropriate representation of fisheries in marine planning systems needs to take account of the spatial variability in landings and fishing practices. An understanding of the year to year stability of fisheries patterns can avoid over-reliance on data from short periods that may not accurately reflect longer term patterns
Additional file 1 of From quantitative SBML models to Boolean networks
Creators: name: Vaginay, Athénaïs
name: Boukhobza, Taha
name: Smaïl-Tabbone, Malika
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 1. SBML model for the running example.
The cost-effectiveness of dacomitinib in first-line treatment of advanced/metastatic epidermal growth factor receptor mutation-positive non-small-cell lung cancer (EGFRm NSCLC) in Sweden
Creators: name: Nilsson, Fredrik O.L.
name: Gal, Peter
name: Houisse, Ivan
name: Ivanova, Jasmina I
name: Asanin, Sandra T
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Although the benefit of first-line epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) over chemotherapy in EGFR mutation-positive (EGFRm) non-small-cell lung cancer (NSCLC) has been demonstrated in clinical trials, the optimal treatment sequence remains unclear. The objective of our study was to evaluate the cost-effectiveness of dacomitinib in Sweden versus afatinib and osimertinib in first-line treatment of EGFRm NSCLC. A partitioned survival model was developed with three health states: progression-free, post-progression, and death. Progression-free and overall survival curves were used to inform movements between states. Clinical data were taken from randomized trials, compared via a network meta-analysis (NMA). Utility data were taken from published studies and costs from national Swedish sources. The model used a 15-year time horizon and a Swedish healthcare payer perspective. Sensitivity and scenario analyses were performed. The base-case analysis showed that dacomitinib accrued a total of 2.10 quality-adjusted life years (QALYs) at a total cost of Swedish krona (SEK) 874,615. The incremental cost-effectiveness ratio (ICER) for dacomitinib versus afatinib was SEK 461,556 per QALY gained. The ICER of osimertinib versus dacomitinib, where the small QALY gains of the former came at a high additional cost, was SEK 11,444,709. Deterministic and probabilistic sensitivity analyses confirmed robustness of these results; changes to drug and medical resource use costs and overall survival had the greatest impact on ICER estimates. This model is subject to uncertainty associated with extrapolating long-term treatment effects from shorter trial follow-up periods, although this would also be a limitation when using direct comparison or time-dependent hazard ratios. The NMA was limited by the use of indirect comparison although sensitivity analyses supported the robustness of our findings. Our model demonstrated dacomitinib is cost-effective for first-line EGFRm NSCLC treatment in Sweden versus afatinib and osimertinib.
GUT ON ORBIFOLDS -- Dynamical Rearrangement of Gauge Symmetry --
Creators: name: Hosotani, Yutaka
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Grand unified theory defined on higher-dimensional orbifolds provides a new way to solve the hierarchy problem. In gauge theory on an orbifold many different sets of boundary conditions imposed at orbifold fixed points (branes) are related by large gauge transformations, forming an equivalent class of boundary conditions. Thanks to the Hosotani mechanism the physics remains the same in all theories in a given equivalent class, though the symmetry of boundary conditions differs from each other. Quantum dynamics of Wilson line phases rearranges the gauge symmetry. In the nonsupersymmetric SU(5) model the presence of bulk fermions leads to the spontaneous breaking of color SU(3). In the supersymmetric model with Scherk-Schwarz SUSY breaking, color SU(3) is spontaneously broken even in the absence of bulk fermions if there are Higgs multiplets.
description: 16 pages, 3 figures. Proceeding for SCGT 2002 (Nagoya, December 2002)
Beyond The Real : Domestic Interventions in Support of Digital Overlay
Creators: name: Sangulin, Angelina
Publisher: name: The University of British Columbia
Year: 2019

description: This project is dedicated to a possible reality, one in which the body inhabits the real, while simultaneously perceptually consuming the digital. The design process investigates the boundaries, possibilities and consequences of domestic design and architectural consideration within such a reality. Sensorial perception of space and verification of perception is explored within the most intimate space—that of the home. While pursuing practical design goals, the project places into question agency in the digital age, the idea of free will and simulation. If the simulation is indistinguishable from reality, does it matter it is not reality? How does one design within this realm?
IFAD RESEARCH SERIES 35 - Climate change mitigation potential of agricultural practices supported by IFAD investments: An ex ante analysis
Creators: name: Richards, Meryl
name: Arslan, Aslihan
name: Cavatassi, Romina
name: Rosenstock, Todd
name: Richards, Meryl
name: Arslan, Aslihan
name: Cavatassi, Romina
name: Rosenstock, Todd
Publisher: name: Unknown
Year: 2019
Subjects: subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: Environmental Economics and Policy
subject: CLIMATIC CHANGE
subject: CLIMATE CHANGE MITIGATION
subject: CLIMATE SMART AGRICULTURE
subject: AGRICULTURAL PROJECTS

description: International discussions on climate change increasingly recognize the importance of agriculture in adaptation and mitigation efforts. This study estimates the mitigation potential of agricultural practices supported by IFAD’s current investments in order to provide guidance for the design of future investments. Using data from field studies in scientific literature, this research estimates the effects of a large set of agricultural practices promoted by IFAD (and other development agencies) on soil organic carbon stocks, nitrous oxide emissions from soils, and methane emissions from rice paddies. Findings identify soil and rice management practices with the largest mitigation potential and those that can potentially increase emissions; discuss uncertainties in mitigation analyses; and provide recommendations to improve monitoring of mitigation benefits.
Bivariate negative binomial regression model with excess zeros and right censoring: an application to Indonesian data
Creators: name: Saffari, Seyed Ehsan
name: Allen, John Carson
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: We propose a bivariate hurdle negative binomial (BHNB) regression model with right censoring to model correlated bivariate count data with excess zeros and few extreme observations. The parameters of the BHNB regression model are obtained using maximum likelihood with conjugate gradient optimization. The proposed model is applied to actual survey data where the bivariate outcome is number of days missed from primary activities and number of days spent in bed due to illness during the 4-week period preceding the inquiry date. We compared the right censored BHNB model to the right censored bivariate negative binomial (BNB) model. A simulation study is conducted to discuss some properties of the BHNB model. Our proposed model demonstrated superior performance in goodness-of-fit of estimated frequencies.
title: Glycoproteins and Memory Formation in the Day-Old Chick
Creators: name: Koles, Kate
Publisher: name: The Open University
Year: 1999

description: Passive avoidance training in day-old chicks results in a cascade of biochemical, physiological and morphological events lasting for at least 24 hrs after training. One of these steps is an increase in fucose incorporation into synaptic plasma membrane (SPM) glycoproteins, which also occurs in other animal species and learning tasks. In order to identify these fucosylated glycans, the glycosylation profile of chicken synaptic plasma membrane (SPM) glycoproteins has been investigated. N- and O-linked glycans were released from delipidated pure SPMs by automated hydrazinolysis and fluorescently labelled with 2-aminobenzamide. Labelled glycans were separated according to their size, charge or hydrophilic profile by gel filtration and high-performance liquid chromatography. In the charged glycan fraction, sialylated, sulphated and phosphorylated glycans were detected, whereas the neutral glycan profile was dominated by oligomannosidic structures. Two of the most abundant complex type oligosaccharides have been sequenced. The neutral glycan profiles from trained and quiet chicks did not show any difference, however there were indications of possible learning related changes in the charged glycan fraction. In addition to learning related changes, another analysis investigating the biochemical correlates of neural plasticity using the dark-hatching paradigm was performed. A decrease in sialic acid content in the P2 fraction of dark-hatched chicks was noted, which is tentatively attributed to the undersialylation of small, possibly O-linked glycans.
The Possible Effects of Personal Income Tax and Value Added Tax on Consumer Behaviors
Creators: name: Ak, Ahmet
name: Gumus, Oner
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business
subject: 91B42

description: In economics literature, it is accepted that all people are rational and they try to maximize their utilities as possible as they can. In addition, economic theories are formed with the assumptions not suitable to real life. For instance, indifference curves are drawn with the assumptions that there are two goods, people are rational, more is preferred to less and so on. Hence, the consumer behaviors are guessed according to this analysis. Nevertheless, these are invalid in real life. And this inconsistencey are examined by behavioral economics and neuroeconomics. Behavioral economics claims that people can behave what they are not expected since people can be irrational, their willpower is limited and altruistic behaviors can be seen and they can give more value to what they own. As a result of these, consumer behaviors become more different than that of economic theory. In addition to behavioral economics, neuroeconomics also examines consumer behaviors more differently than mainstream economic theory. It emphasizes the people using prefrontial cortex of the brain are more rational than the people using hippocampus of the brain. Therefore, people can make illogical choices compared to economic theory. In these cases, levying taxes such as personal income tax or value added tax can be ineffective or effective. In other words, the effect becomes ambigious. Hence,the hypothesis that if government desires to levy personal income tax or value added tax, it makes a detailed research in terms of productivity of taxes forms the fundamental of this study.
description: 10 pages, 23 references
Million-atom molecular dynamics simulation by order-N electronic structure theory and parallel computation
Creators: name: Geshi, Masaaki
name: Hoshi, Takeo
name: Fujiwara, Takeo
Publisher: name: arXiv
Year: 2003
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Parallelism of tight-binding molecular dynamics simulations is presented by means of the order-N electronic structure theory with the Wannier states, recently developed (J. Phys. Soc. Jpn. 69,3773 (2000)). An application is tested for silicon nanocrystals of more than millions atoms with the transferable tight-binding Hamiltonian. The efficiency of parallelism is perfect, 98.8 %, and the method is the most suitable to parallel computation. The elapse time for a system of $2\times 10^6$ atoms is 3.0 minutes by a computer system of 64 processors of SGI Origin 3800. The calculated results are in good agreement with the results of the exact diagonalization, with an error of 2 % for the lattice constant and errors less than 10 % for elastic constants.
description: 5 pages, 3 figures
Inflation without gauge redundancy
Creators: name: Urbano, Alfredo
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the context of gauge theories, observable quantities, if properly defined and computed, do not depend on the gauge-fixing procedure. In this paper, we develop a formalism that implements this (apparent) tautology in the case of inflation. As a simple application, we discuss Coleman-Weinberg "hilltop" inflation.
Optical Properties of ZnP2 Nanoparticles in Zeolite
Creators: name: Yeshchenko, O. A.
name: Dmitruk, I. M.
name: Koryakov, S. V.
name: Barnakov, Yu. A.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report that for the first time the nanoparticles of II-V semiconductor (ZnP2) were prepared and studied. ZnP2 nanoparticles were prepared by incorporation into zeolite Na-X matrix. Absorption, diffuse reflection (DR) and photoluminescence (PL) spectra of the ZnP2 nanoclusters incorporated into the supercages of zeolite Na-X were measured at the temperature 77 K. Five bands B1-B5 are observed in both the DR and PL spectra demonstrating the blue shift from the line of free exciton in bulk crystal. We attribute the B1-B5 bands to some stable nanoclusters with size less than the size of zeolite Na-X supercage. We observed Stokes shift of the PL bands from the respective absorption bands. The nonmonotonic character of its dependence on the cluster size can be explained as the result of competition of the Frank-Condon shift and the shift due to electronic relaxation.
description: Submitted to Microporous and Mesoporous Materials
Energy- and Quality-Aware Video Request Policy for Wireless Adaptive Streaming Clients
Creators: name: Díaz, César
name: Fernández, Antonio
name: Sacristán, Fernando
name: García, Narciso
Publisher: name: arXiv
Year: 2024
Subjects: subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We present a straightforward, non-intrusive adaptive bit rate streaming segment quality selection policy which aims at extending battery lifetime during playback while limiting the impact on the user's quality of experience, thus benefiting consumers of video streaming services. This policy relies on the relationship between the available channel bandwidth and the bit rate of the representations in the quality ladder. It results from the characterization of the energy consumed by smartphones when running adaptive streaming client applications for different network connections (Wifi, 4G, and 5G) and the modeling of the energy consumed as a function of said relationship. Results show that a significant amount of energy can be saved (10 to 30%) by slightly modifying the default policy at the expense of a controlled reduction of video quality.
Impurities block the alpha to omega martensitic transformation in titanium
Creators: name: Hennig, R. G.
name: Trinkle, D. R.
name: Bouchet, J.
name: Srinivasan, S. G.
name: Albers, R. C.
name: Wilkins, J. W.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The onset and kinetics of martensitic transformations are controlled by impurities trapped during the transformation. For the alpha to omega transformation in Ti, ab initio methods yield the changes in both the relative stability of and energy barrier between the phases. Using the recently discovered transformation pathway, we study interstitial O, N, C; substitutional Al and V; and Ti interstitials and vacancies. The resulting microscopic picture explains the observations, specifically the suppression of the transformation in A-70 and Ti-6Al-4V titanium alloys.
description: 4 pages, 2 figures, 2 tables
Learning Molecular Dynamics with Simple Language Model built upon Long Short-Term Memory Neural Network
Creators: name: Tsai, Sun-Ting
name: Kuo, En-Jui
name: Tiwary, Pratyush
Publisher: name: arXiv
Year: 2020
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chemical Physics (physics.chem-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Recurrent neural networks (RNNs) have led to breakthroughs in natural language processing and speech recognition, wherein hundreds of millions of people use such tools on a daily basis through smartphones, email servers and other avenues. In this work, we show such RNNs, specifically Long Short-Term Memory (LSTM) neural networks can also be applied to capturing the temporal evolution of typical trajectories arising in chemical and biological physics. Specifically, we use a character-level language model based on LSTM. This learns a probabilistic model from 1-dimensional stochastic trajectories generated from molecular dynamics simulations of a higher dimensional system. We show that the model can not only capture the Boltzmann statistics of the system but it also reproduce kinetics at a large spectrum of timescales. We demonstrate how the embedding layer, introduced originally for representing the contextual meaning of words or characters, exhibits here a nontrivial connectivity between different metastable states in the underlying physical system. We demonstrate the reliability of our model and interpretations through different benchmark systems and a single molecule force spectroscopy trajectory for multi-state riboswitch. We anticipate that our work represents a stepping stone in the understanding and use of RNNs for modeling and predicting dynamics of complex stochastic molecular systems.
title: Determining sources of capelin recruits in the Saguenay-St. Lawrence Marine Park (Canada) using otolith chemistry
Creators: name: Lazartigues, Angélique
name: Sirois, Pascal
name: Plourde, Stéphane
name: Dodson, Julian
Publisher: name: ASC 2012 - Theme session J
Year: 2024
Subjects: Fisheries and aquaculture
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.The Saguenay-St. Lawrence Marine Park (SSLMP) is an important feeding area for whales, seals and seabirds. The reserve includes a large portion of St. Lawrence Estuary, and most of the Saguenay Fjord (Canada). Understanding how capelin (Mallotus villosus), a key foraging species, is maintained in the SSLMP is important to preserve this feeding area. Our aim is to determine whether capelin in the SSLMP recruit locally through larval retention or derive from other spawning sites and look at connectivity throughout the Fjord-Estuary system. Otolith chemistry is a great tool to achieve our objective. Indeed, elements are stored in the increments of otoliths. Concentrations derive from surrounding waters and are regulated by physiological and environmental parameters. So, otolith elemental signatures in early life stage capelin otoliths may be a witness of the spawning site. The first step consists in characterisation of otolith signatures of spawning sites, exploring larval capelins (n=290, otolith diameter 10-20µm) caught in 2009 throughout the Fjord-Estuary system, within and beyond the SSLMP boundaries. Multi-elemental analysis was performed using LA-ICP-MS method adapted to small samples. The second step performs similar analyses of a subsample of 1+ juvenile capelin caught in SSLMP in 2010 to determine sources of recruits (n=35). Some of the elements that are measured in larval otoliths varied among sampled stations, within SSLMP and in other spawning sites upstream and downstream in the estuary and western Gulf. That will form the basis of a mixed-stock analysis to determine the spatial extent and degree of connectivity between the park and spawning areas.
Constraints on Sparticle Spectrum in different Supersymmetry Breaking Models
Creators: name: Huitu, Katri
name: Laamanen, Jari
name: Pandita, P. N.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We derive sum rules for the sparticle masses in different models of supersymmetry breaking. This includes the gravity mediated models (SUGRA models) as well as models in which supersymmetry breaking terms are induced by super-Weyl anomaly (AMSB models). These sum rules can help in distinguishing between these models. In particular we obtain an upper bound on the mass of the lightest neutralino as a function of the gluino mass in SUGRA and AMSB models.
description: 3 pages, latex, two figures, macros included. Talk presented at IXth International Symposium on Particles, Strings and Cosmology(PASCOS'03), TIFR, MUmbai, India, January 3 - 8, 2003. To appear in the proceedings
Intermittent origin of the large violations of the fluctuation dissipation relations in an aging polymer glass
Creators: name: Buisson, L.
name: Ciliberto, S.
name: Garcimartin, A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The fluctuation-dissipation relation (FDR) is measured on the dielectric properties of a polymer glass (polycarbonate)in the range $20mHz - 100Hz$. It is found that after a quench below the glass transition temperature the fluctuation dissipation theorem is strongly violated. The amplitude and the persistence time of this violation are decreasing functions of frequency. At frequencies larger than 1Hz it persists for about $3h$. The origin of this violation is a highly intermittent dynamics characterized by large fluctuations. The relevance of these results for recent models of aging dynamics are discussed.
description: to be published in Europhysics Letters
Η επίπτωση της πανδημίας του Covid 19 στον Δημόσιο Χώρο – Καταγραφή και συγκριτική αξιολόγηση καλών πρακτικών αξιοποίησης Δημόσιου Χώρου στα πλαίσια αντιμετώπισης της πανδημίας του Covid -19
Creators: name: Παπαφίλης, Πέτρος Γεωργίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2021
Subjects: Δημόσιος χώρος
Covid-19 πανδημία,
Καλές πρακτικές
Κοινωνικό-χωρικές επιπτώσεις
Ανθεκτικότητα
Public space
Covid-19 pandemic
Best practices
Social-spatial impact
Resilience

description: Αντικείμενο της παρούσας ερευνητικής προσπάθειας είναι η μελέτη των επιπτώσεων της πανδημίας του Covid-19 στον Δημόσιο χώρο και η συγκριτική αξιολόγηση των διαφόρων πρακτικών αξιοποίησής του στα πλαίσια αντιμετώπισης της εξάπλωσης του ιού. Στα πλαίσια αυτά αρχικά οριοθετείται εννοιολογικά ο Δημόσιος χώρος, παρουσιάζονται συνοπτικά αρκετές από τις διάφορες εναλλακτικές προσεγγίσεις του, αναλύεται η διάκρισή του από τον ιδιωτικό και παρατίθενται τα είδη, χαρακτηριστικά και πλεονεκτήματα του. Εν συνεχεία ακολουθούν οι γενικές και ειδικές κοινωνικό-χωρικές επιπτώσεις του Covid-19 στον Δημόσιο χώρο και εξετάζονται επτά (7) ερευνητικές σχετικές υποθέσεις. Στα συμπεράσματα του πρώτου αυτού τμήματος αποτυπώνονται τα αποτελέσματα της έρευνας και συνδέονται τα ερευνητικά αυτά ερωτήματα με τις διάφορες μορφές ανθεκτικότητας. Στο δεύτερο μέρος διενεργείται μία συγκριτική παράθεση και αξιολόγηση δεκαεννέα (19) καλών πρακτικών αξιοποίησης του Δημόσιου χώρου για την αντιμετώπιση της πανδημίας, σε επίπεδο χωρικής εφαρμογής, χρονικής διάρκειας, λειτουργικού χαρακτήρα, συμμετοχικότητας, περιβαλλοντικού αποτυπώματος, οικονομικού κόστους, αποτελεσματικότητας και σχέσης με τον επίσημο σχεδιασμό. Στο συμπεράσματα αποτυπώνεται μια συνολική αξιολόγηση αφενός των πρακτικών που έτυχαν εφαρμογής στην πόλη της Θεσσαλονίκης αφετέρου της δυνατότητας μελλοντικής υλοποίησης των λοιπών δράσεων σε αυτήν.
description: The subject of this research effort is the study of the impact of the Covid-19 pandemic on public space and the benchmarking of the practices that were used in response to the spread of the virus. In this context, Public Space is initially defined, several of its various alternative approaches are presented, the distinction of Public Space vs Private Space is analyzed and the types, characteristics and advantages of Public Space are listed. The general and specific social-spatial effects of Covid-19 on Public Space are then presented and seven (7) research related cases are examined. The conclusions of this first section reflect the results of the research and link these research questions to the various forms of resilience. In the second part, follows a comparative presentation and evaluation of nineteen (19) best practices, concerning the use of Public Space, in order to address the pandemic, at the level of spatial application, duration, operational character, inclusiveness, environmental footprint, financial cost, efficiency and relation to formal planning. The conclusions present a comprehensive assessment of the practices applied in the city of Thessaloniki and the possibility of future implementation of other actions in the city.
title: Development and Characterisation of PC12 Cell Lines Allowing Inducible Expression of Prion Proteins Carrying Pathogenic Mutations
Creators: name: Quaglio, Elena
Publisher: name: The Open University
Year: 2005

description: Inherited prion diseases are linked to mutations in the prion protein (PrP)p gene that are presumed to favor conversion of PrP into a neurotoxic isoform (PrpSc) Several cellular models of inherited prion diseases have been Q developed in which mutant PrP costitutively expressed acquires PrPSc-like properties but is not cytotoxic. However, the use of constitutive models does not exclude the potential toxicity of mutant PrP, as it can be speculated that only J clones resistant to PrP toxicity are selected after clonal selection. To rule out n this possibility a tetracycline-inducible (Tet-on) model was developed in this thesis, in which PrP expression is switched on after clonal selection.
 cDNAs encoding mouse wild-type PrP, as well as mouse PrP homologues of the human D178N (D177N/M128 and D177NA/128) and nine-octapeptide (PG14) mutations under the control of the tetracycline-responsive element, were transfected in PC12 Tet-on cells. The Tet-on system was chosen based on the lack of pleiotropic or toxic effects and because it allows a tightly regulated expression of the protein of interest. To ensure unwanted background expression of PrP in the absence of inducer, cells were co-transfected with J pTet-tTS, encoding the tet-controlled transcriptional silencer.
 The D177N and PG14 mutants expressed in this system displayed biochemical properties reminiscent of PrP^^, including detergent insolubility and low protease resistance. Low levels of mutant PrPs were detected on the cell surface by confocal immunofluorescence analysis compared to wild-type PrP. These mutant displayed reticular intracellular distribution, suggesting impaired delivery to the cell surface and retention in the endoplasmic reticulum (ER).
 Evaluation of cellular viability revealed a decrement in cell survival after 96 h of mutant PrP expression, associated with an increased number of apoptotic cells. This effect was not fully consistent and was not exacerbated by Q neuronal differentiation with NGF or by treating cells with FI2O2, tunicamycin, or by removing serum. The results presented in this thesis also demonstrate that expression of PrP does not protect PC 12 Tet-on cells from such stresses.
 To explore the possibility that expression of mutant PrPs triggered toxic -1 response pathways in the ER, the mRNA level of ER stress markers was measured. The results shown in this thesis indicate that, although the altered intracellular distribution of mutant PrPs suggested retention of the protein in the endoplasmic reticulum, ER stress responses were not detected.
title: Boom in boarfish abundance: Insight from otolith analysis
Creators: name: Coad, Julie Olivia
name: Hüssy, Karin
Publisher: name: ASC 2012 - Theme session J
Year: 2024
Subjects: Fisheries and aquaculture
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.The boarfish (Capros aper) is a pelagic shoaling species widely distributed along the Northeast Atlantic continental shelf. In recent years, this species has experienced a dramatic boom in abundance in the Bay of Biscay and Celtic Sea. This study aims at resolving the mechanisms responsible for this increase in stock size. Based on annual otolith growth increments, we developed a growth chronology as a proxy for stock fecundity.