cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Health solutions to improve post-intensive care outcomes: a realist review protocol
Creators: name: Howard, A. Fuchsia
name: Currie, Leanne M.
name: Bungay, Vicky
name: Meloche, Margaret
name: McDermid, Robert
name: Crowe, Sarah
name: Ryce, Andrea
name: Harding, William
name: Haljan, Gregory
Publisher: name: BioMed Central
Year: 2019

description: Background: While 80% of critically ill patients treated in an intensive care unit (ICU) will survive, survivors often suffer a constellation of new or worsening physical, cognitive, and psychiatric complications, termed post-intensive care syndrome. Emerging evidence paints a challenging picture of complex, long-term complications that are often untreated and culminate in substantial dependence on acute care services. Clinicians and decision-makers in the Fraser Health Authority of British Columbia are working to develop evidence-based community healthcare solutions that will be successful in the context of existing healthcare services. The objective of the proposed review is to provide the theoretical scaffolding to transform the care of survivors of critical illness by a synthesis of relevant clinical and healthcare service programs. Methods: Realist review will be used to develop and refine a theoretical understanding of why, how, for whom, and in what circumstances post-ICU program impact ICU survivors’ outcomes. This review will follow the recommended five steps of realist review which include (1) clarifying the scope of the review and articulating a preliminary program theory, (2) searching for evidence, (3) appraising primary studies and extracting data, (4) synthesizing evidence and sharing conclusions, and (5) disseminating and implementing recommendations. Discussion: This realist review will provide a program theory, encompassing the contexts, mechanisms, and outcomes, to explain how clinical and health service interventions to improve ICU survivor outcomes operate in different contexts for different survivors, and with what effect. This review will be an evidentiary pillar for health service development and implementation by our knowledge user team members as well as advance scholarly knowledge relevant nationally and internationally. Systematic review registration PROSPERO CRD42018087795
Postexercise hemodynamics and control of heat loss responses following exercise-induced hyperthermia
Creators: name: Gagnon, Daniel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Health Sciences, Recreation.

description: Purpose. The purpose of this thesis was to investigate the nonthermoregulatory control of cutaneous vascular conductance (CVC) and sweating during recovery from exercise-induced hyperthermia as well as to determine possible sex-related differences during the recovery period. It was hypothesized that an active and passive recovery would maintain mean arterial pressure (MAP), CVC and sweat rate at higher levels than an inactive recovery and result in a faster rate of esophageal temperature (Tes) decay. It was also hypothesized that changes in MAP, CVC and sweat rate would be sex dependent. Methods. Eighteen participants (9 males, 9 females) were rendered hyperthermic by exercise (i.e. Tes = 39.5°C) and recovered in one of three recovery modalities for 60-min: (1) active, (2) inactive or (3) passive. Tes, CVC, sweat rate, cardiac output, stroke volume, heart rate, total peripheral resistance, and MAP were recorded at baseline and 2, 5, 12, 20 and every 10-min until the end of recovery. Results. Both active and passive recoveries were equally effective in maintaining MAP, CVC and sweat rate at greater levels compared with an inactive recovery (p ≤ 0.05). A significantly lower Tes was subsequently observed during passive recovery at 20-min and for the rest of recovery compared to the active mode (p ≤ 0.05). Sex did not affect any of the measured variables at any time point during any recovery mode, with the exception of sweat rate which was significantly higher in males throughout the recovery period (p ≤ 0.05). Conclusion. We conclude that despite an important thermal drive, nonthermal input remains an important influence in the modulation of postexercise heat loss responses. Further, action of the muscle pump/mechanoreceptors is the main nonthermal determinant in the postexercise modulation of MAP, CVC and sweat rate irrespective of sex.
Balancing peer and server energy consumption in large peer-to-peer file distribution systems
Creators: name: Andrew, Lachlan L. H.
name: Hecq, Dominique
name: Nguyen, Thuy T. T.
Publisher: name: Swinburne
Year: 2024

description: Network induced energy consumption is a significant fraction of all ICT energy consumption. This paper investigates the most energy efficient way to distribute a file to a large number of recipients. It is shown that using peer-to-peer and naively minimizing the transfer time results in energy consumption that is an order of magnitude larger than simply distributing directly from a server, but that with careful management peer-to-peer systems can reduce the server's cost without increasing overall energy consumption.
Supplementary document for Continuous imaging of large-volume tissues with a machinable optical clearing method at subcellular resolution - 4886226.pdf
Creators: name: Zhou, Can
name: Zheng, Ting
name: Luo, Ting
name: Yan, Cheng
name: Sun, Qingtao
name: Ren, Miao
name: Zhao, Peilin
name: Chen, Wu
name: Ji, Bingqing
name: Wang, Zhi
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Quantum Optics

description: supplemental materials
title: Entero-RM en el estudio de pacientes con enfermedad de Crohn.
Creators: name: Alfonso Cerdan, Sheila
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Inflammation
subject: Oedema
subject: Imaging sequences
subject: Contrast agent-oral
subject: CT
subject: MR
subject: Gastrointestinal tract
subject: Small bowel
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
- Introducción a la enfermedad de Crohn (EC). - Definir el papel de la enteroresonancia magnética (Entero-RM) en la evaluación del intestino delgado en pacientes afectos de EC y su correlación con los hallazgos en el TC multidetector...
title: Colangiocarcinoma intrahepático. Correlación de patrones de captación entre CEUS y TAC
Creators: name: Moral Cano, Martín
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ultrasound
subject: CT
subject: Abdomen
subject: Liver

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Establecer la frecuencia y utilidad de los hallazgos morfológicos en TAC y ecografía modo B propios del colangiocarcinoma intrahepático. Establecer hipótesis acerca del crecimiento y la biología de este tipo de tumor. Determinar los patrones de...
Family communication and genetics: Developing a framework for effective interventions
Creators: name: Wiens, Miriam E
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Speech Communication.
subject: Health Sciences, Medicine and Surgery.

description: Objective. To create a theory-based framework to guide the development of interventions for assisting genetics health services clients to communicate results of genetic testing to at-risk family members. Methods. Systematic review methods were used to collect evidence on the barriers and facilitators of disclosure. After appraisal of several theories against key criteria, the Theory of Planned Behaviour (TPB) was chosen as the theory to base the framework on. The framework was developed through a qualitative process which incorporated the all the available evidence from the literature. A preliminary examination of the utility of the framework was done through a cross-sectional survey. Results. The framework explains the act of disclosing a genetic test results to at-risk family members in terms of the TPB. Results from the cross-sectional survey, conducted in a population not previously studied, were generally consistent with the information presented in the framework and found in the literature. Conclusions. The framework has potential to be used in developing interventions; however, results need to be replicated in prospective studies with larger samples.
title: Utilidad de la Biopsia pulmonar coaxial guiada por TC en el diagnóstico histológico del cáncer de pulmón
Creators: name: Gallego Sánchez, Juan Antonio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Lung
subject: Oncology
subject: Interventional non-vascular
subject: CT
subject: Percutaneous
subject: Biopsy
subject: Neoplasia

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
En el tratamiento del cáncer de pulmón es importante alcanzar un diagnóstico histológico específico,
además de la realización de análisis moleculares (mutación EFGR,
determinación de oncogenes) que permitan llevar a cabo un terapia...
УСТНЫЙ ПЕРЕВОД КАК СПОСОБ КОРРЕКЦИИ ГРАММАТИКИ И РАЗВИТИЯ КРАТКОЙ СЛУХОВОЙ ПАМЯТИ В КУРСЕ РКИ
Creators: name: Е.В. Нечаева
name: Б.И. Караджев
Publisher: name: Мир науки, культуры, образования
Year: 2020
Subjects: обучение РКИ
перевод
краткая слуховая память
грамматика

description: В статье проанализирован методический прием перевода при изучении русского языка как иностранного. На основании научно-методических и лингви стических источников предложен план урока с комплексом упражнений по устному переводу. Предлагаемый в статье подход к использованию перевода в процессе преподавания РКИ в мононациональной группе учащихся, осваивающих русский язык на уровнях B1 – С2, предполагает рассматривать перевод как средство активизации изученных ранее языковых явлений. Также в статье анализируются методические приемы, способствующие улучшению крат ковременной слуховой памяти обучающихся, что актуально не только для будущих переводчиков, но и для всех тех, кто овладевает иностранными языка ми, в частности русским языком как иностранным. Выявлено, что применение данного метода способствует развитию коммуникативных знаний, умений и навыков учащихся и их краткой слуховой памяти при обучении РКИ.
Cheberdord burmeisteri Allsopp 2025, new combination
Creators: name: Allsopp, Peter G.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Cheberdord
Cheberdord burmeisteri

description: Cheberdord burmeisteri (Brenske, 1892), new combination
(Figs 2–9, 12, 16, 19–22, 24)
Holotrichia burmeisteri Brenske, 1892: 187.
Metatrogus burmeisteri: Matsumoto 2008: 11.
Lepidiota carolinensis Arrow, 1939: 86, new synonymy.
Description. Cartwright & Gordon (1971: 280). Dorsum Figs 2–7, 12, 22; aedeagus Figs 16, 19–21.
Distribution. Palau. Babelthuap: Badeldaob [Babelthuap]; Melokeiok [Melekeok, 7.52°N, 134.60°E]; Ngeremlengui [7.53°N, 134.56°E]; Ogiwal [Nigiwal, 7.57°N 134.62°E; Airhi [Airai, 7.36°N 134.54°E]; Koror [7.34°N 134.48°E]. Guam (intercepted in transit, Fig. 24).
description: Published as part of Allsopp, Peter G., 2025, Holotrichia burmeisteri Brenske, 1892 and allies (Coleoptera: Scarabaeidae: Melolonthinae: Rhizotrogini): a tale of four genera and four countries, pp. 166-178 in Zootaxa 5631 (1) on page 175, DOI: 10.11646/zootaxa.5631.1.8, http://zenodo.org/record/15326977
Étude des perceptions et de la pratique avouée des infirmières de néonatologie dans une perspective de soins centres sur la famille
Creators: name: Ward, Vicky E
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Health Sciences, Nursing.

description: Cette étude a pour but de décrire les perceptions et la pratique avouée des infirmières en regard des éléments clés de la philosophie de soins centres sur Ia famille (SCF) ainsi que d'identifier certaines variables personnelles ou professionnelles qui ont une influence sur ceux-ci, dans une unité de sains intensifs néonataux (USIN) de niveau III. Il s'agit d'un devis de recherche de type descriptif ayant un échantillon de convenance de 50 infirmières travaillant dans l'USIN au Centre Hospitalier pour Enfants de l'Est de l'Ontario (CHEO). Le questionnaire FCCQ-R développe par Bruce en 1995 a été modifié et a servi à identifier les perceptions, Ia pratique avouée et les variables personnelles et professionnelles des infirmières. Les résultats démontrent des perceptions positives des infirmières envers les éléments clés des SCF mais également une différence significative entre leurs perceptions et leur pratique avouée. La situation familiale semble influencer les perceptions des infirmières des SCF mais non leur pratique avouée. (Abstract shortened by UMI.)
title: Diagnóstico por imagen de hemoperitoneo espontáneo
Creators: name: Mendoza Arnau, Inmaculada
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ultrasound
subject: CT
subject: Spleen
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Presentar causas infrecuentes de hemoperitoneo no traumático. Describir signos en ecografía y TCMD indicativos de la presencia de sangre en la cavidad abdominal. Precisar la importancia de los estudios por imagen en su detección precoz para...
title: The phase stacking diagram of colloidal mixtures under gravity
Creators: name: de las Heras, Daniel
name: Schmidt, Matthias
Publisher: name: University of Bayreuth
Year: 2013
Subjects: subject: 530

description: The observation of stacks of distinct layers in a colloidal or liquid mixture in the sedimentation-diffusion equilibrium is a striking consequence of bulk phase separation. Drawing quantitative conclusions about the phase diagram is, however, very delicate. Here we introduce the Legendre transform of the chemical potential representation of the bulk phase diagram to obtain a unique stacking diagram of all possible stacks under gravity. Simple bulk phase diagrams generically lead to complex stacking diagrams. We apply the theory to a binary hard core platelet mixture with only two-phase bulk coexistence, and find that the stacking diagram contains six types of stacks with up to four distinct layers. These results can be tested experimentally in colloidal platelet mixtures. In general, an extended Gibbs phase rule determines the maximum number of sedimented layers as a function of the number of binodals and their inflection points.
La représentation de la Chine dans "Le fils du ciel" de Victor Segalen et "La condition humaine" d'André Malraux.
Creators: name: Situ, Wanman (Marianne).
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Literature, Romance.

description: Ce travail etudie l'exotisme chinois dans Le Fils du Ciel de Victor Segalen et dans La Condition humaine d'Andre Malraux. Il le fait en etablissant une comparaison entre les deux oeuvres sur les elements qui constituent l'univers romanesque chinois de Segalen et de Malraux: les formes narratives, l'espace et les personnages. Quelles Chines sont representees sous la plume de Segalen et de Malraux? Qu'est-ce qui caracterise l'exotisme chinois dans les deux romans a l'etude? Quelles sont les differences et ressemblances et quelles significations pouvons-nous en tirer? Telles sont les questions que cette etude a posees. Sur le plan des formes narratives, on constate que la narration du Fils du Ciel differe de celles de La Condition humaine dans vraisemblablement toutes les perspectives. Ces dissemblances sur le plan des formes narratives sont en effet etroitement liees avec les besoins thematiques des deux romans. Il se degage de cette etude que la Chine, dans Le Fils du Ciel et dans La Condition humaine, est representee de facons radicalement differentes. Alors qu'elle apparai t, dans le roman de Segalen, comme la terre fascinante de la Difference, elle se montre, dans le roman de Malraux, un calque de l'Occident. Ainsi, Segalen et Malraux, auteurs francais de la meme epoque qui, en plus, ont tous les deux vecu en Asie (dans differentes parties certes), traitent-ils le meme sujet exotique, celui de la Chine, de points de vue completement opposes: le point de vue de Segalen est vraisemblablement un point de vue "exo-centrique" qui prete une extreme attention a l'Autre, dans une sensibilite remarquable aux particularismes culturels; tandis que le point de vue de Malraux parai t plutot un point de vue egocentrique qui, par le sentiment d'une superiorite du Moi europeocentriste, vise a assimiler l'Autre au Meme. Alors que Segalen insere l'action romanesque du Fils du Ciel a l'interieur de l'"incomprehensibilite eternelle" de la Chine mystique afin d'obtenir, de l'exotisme, un "enrichissement de soi", Malraux place l'action de La Condition humaine en Chine, mais sans vouloir vraiment toucher le sol de ce pays. Par consequent, l'ecriture segalenienne est une esthetique de l'exotisme dans son vrai sens, tandis que l'ecriture malrucienne est un depaysement sans vraie alterite. (Abstract shortened by UMI.)
Cheberdord dybasi Allsopp 2025, new combination
Creators: name: Allsopp, Peter G.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Cheberdord
Cheberdord dybasi

description: Cheberdord dybasi (Gordon, 1971), new combination
(Figs 13, 17)
Lepidiota dybasi Gordon in Cartwright & Gordon, 1971: 280.
Description. Cartwright & Gordon (1971: 280). Dorsum Fig. 13; aedeagus Fig. 17.
Distribution. Palau. Peleliu, including Amaingal Mt [ca. 7°N, 134.2°E] and east and west coasts (Cartwright & Gordon 1971).
description: Published as part of Allsopp, Peter G., 2025, Holotrichia burmeisteri Brenske, 1892 and allies (Coleoptera: Scarabaeidae: Melolonthinae: Rhizotrogini): a tale of four genera and four countries, pp. 166-178 in Zootaxa 5631 (1) on page 175, DOI: 10.11646/zootaxa.5631.1.8, http://zenodo.org/record/15326977
ОДАРЕННОСТЬ И ОСОБЕННОСТИ РАБОТЫ С ОДАРЕННЫМИ ДЕТЬМИ ПО МАТЕМАТИКЕ
Creators: name: П.А. Верфильева
name: О.А. Кириллова
Publisher: name: Мир науки, культуры, образования
Year: 2020
Subjects: одаренные дети
интеллектуальный потенциал
математическая одаренность
виды одаренности

description: В данной статье поднимается актуальная проблема современности – потребность в людях, умеющих принимать нестандартные решения в сложившей ся ситуации, т.е. речь идет о приумножении интеллектуального потенциала нашей страны, его поддержке. К такому потенциалу относятся одаренные дети. Представлен психолого-педагогический анализ определения «одаренности» разными авторами. Указывается необходимость развития одаренных детей. Также выделены виды одаренности и дана краткая их характеристика. Особое внимание уделено математической одаренности. Рассмотрены некоторые особенности работы с одаренными детьми по математике, опираясь на которые можно построить процесс обучения таким образом, чтобы продолжить развивать их способности.
The stabilization of urban pavements founded on expansive clay subgrades in Victoria, Australia
Creators: name: Sukkar, Fuad
Publisher: name: Swinburne
Year: 2024

description: Expansive clays cover vast areas of the globe including the United States, Canada, South Africa, Middle East, Europe and Australia. Movements in expansive clays are the result of moisture change. The migration of moisture is affected mainly by the suction characteristics of the clay and by the neighbouring tree roots. The clay profile near the surface that is within the depth of seasonal movement experiences cycles of shrinkage and heave that causes pavements to crack and lose their shape Moisture control of expansive soil subgrades for Local Government pavements continues to cause problems that are responsible for maintenance and performance of these pavements. Pavement damage is featured through the presence of longitudinal cracks, loss of shape and rotation of the kerb and channel. The current stabilization techniques are not entirely suitable for either existing or new urban pavements founded on expansive soils. The presence of trees and underground services will always remain the biggest challenge to the practical and economical viability of any method. Therefore, there is a need to seek a new technique of creating a stable moisture regime beneath urban pavements. The use of conventional heating in a road construction process was investigated in the early 1900s. This treatment method was abandoned for many reasons, including the insufficient depth of heat penetration, economics and environmental concerns. The hypothesis of this research is that clay processing using microwave (M/W) heating may provide a solution to expansive subgrades of new and existing pavements due to a number of factors. These include: penetrating radiation, controllable electric field distribution, rapid heating, selective heating of materials through differential absorption, self-limiting reactions, and finally the potential for portability and remote processing. The M/W processing of expansive clays, which is non-intrusive nature, is a completely new approach that is examined by the author. It involves the use of microwaves to change the clay particles to produce a new microstructure that is not capable of rehydration. The research provides an evaluation of the conditions or parameters needed for a successful application of M/W processing. It also identifies its limitations and weaknesses, and finally provides a list of further research work required for a prototype insitu application. The M/W method is shown to be an attractive and favorable possibility for future large-scale insitu applications.
Crystal size distribution of feldspar crystals from granitic rocks of Eurajoki (Finland) and the South Mountain Batholith (Nova Scotia, Canada)
Creators: name: Machado, Gabriel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Geology.

description: Crystal size distributions (CSDs) studies of igneous rocks allow the quantification of sizes of mineral and contribute to a better understanding of crystallization conditions. Since most CSD studies have been made on mafic and felsic volcanic rocks and mafic plutonic rocks, one of the goals of this research was to do a large number of CSDs on feldspar crystals from two well-known granitic localities: the Eurajoki stock (Finland) and the South Mountain Batholith (Nova Scotia, Canada). Crystal size data were measured at different scales and on different media (outcrop, rock slabs and thin sections). CSDs were constructed from the data collected at the various scales using the program CSD corrections and plotted as amalgamated CSDs for each sample. CSDs of potassic felspars from Eurajoki samples were curved upwards and the characteristic lengths indicate three populations of crystals sizes. It is proposed that potassic feldspar crystals have been texturally coarsened likely because the Eurajoki melts were emplaced in a hot environment. This minimized undercooling and the temperature was buffered by latent heat of fusion near the liquidus. Thus large crystals grew at the expense of smaller ones. With cooling, nucleation and growth of small crystals resumed, yielding the different crystals sizes populations observed. CSDs of plagioclase and potassic felspars from the South Mountain Batholith were also curved upwards and the characteristic lengths indicate two populations of crystals sizes, except for the muscovite leucogranites from the stage 2 plutons, where CSDs are straight. Textural coarsening formed the larger crystals, megacrysts, in the South Mountain Batholith. Here the constant ascent of new magma into the plutons slowed undercooling and buffered the temperature producing the right conditions for textural coarsening.
title: Colecistostomía percutánea: indicaciones, técnica, complicaciones y resultados.
Creators: name: Lopez-Quiñones Llamas, Miguel Torcuato
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Drainage
subject: Ultrasound
subject: Interventional non-vascular

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Nuestro objetivo docente es repasar las indicaciones,
técnica,
resultados y posibles complicaciones de la colecistostomía percutánea...
ПРОБЛЕМЫ, СВЯЗАННЫЕ С РЕАЛИЗАЦИЕЙ ДИСТАНЦИОННЫХ ОБРАЗОВАТЕЛЬНЫХ ТЕХНОЛОГИЙ
Creators: name: А.И. Синицкий
name: Ю.С. Шишкова
name: А.А. Колесникова
name: О.Л. Колесников
Publisher: name: Мир науки, культуры, образования
Year: 2020
Subjects: высшее образование
дистанционное образование
проблема
качество образования
организация занятий

description: Статья посвящена актуальной на сегодняшний день проблеме использования дистанционных образовательных технологий. Показано наличие проблем, связанных с дистанционным образованием (снижение качества, организация занятий, академическое мошенничество). Проведено анкетирование 163 сту дентов 1 курса лечебного факультета ЮУГМУ. Участие в исследовании было добровольным и анонимным. Авторы продемонстрировали, что обучением в ЮУГМУ удовлетворены 83,9% респондентов. Результаты опроса показали, что подавляющее большинство студентов отрицательно оценивают качество дистанционного образования. 70% студентов предпочли традиционное обучение. Респонденты выбрали следующие формы лекций: вебинар или лекция в формате pdf. 71,1% изученных работ студентов содержали признаки плагиата. Авторы предлагают использование дополнительных форм контроля.
title: Utilidad de la 18-FDG-PET-TC para confirmar el diagnóstico de colangiocarcinoma sospechado por ecografía abdominal.
Creators: name: Santiago Chinchilla, Alicia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Diagnostic procedure
subject: Staging
subject: Ultrasound
subject: PET-CT
subject: Oncology
subject: Nuclear medicine

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Valorar la utilidad de la 18-FDG-PET-TC en pacientes con sospecha diagnóstica de colangiocarcinoma por ecografía...
Regulation of NADPH oxidase-mediated superoxide production by acetylation and deacetylation
Creators: name: Xia, Ning
name: Tenzer, Stefan
name: Lunov, Oleg
name: Karl, Martin
name: Simmet, Thomas
name: Daiber, Andreas
name: Münzel, Thomas
name: Reifenberg, Gisela
name: Förstermann, Ulrich
name: Li, Huige
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: NADPH oxidase
subject: Rac1
subject: histone deacetylase
subject: histone acetyltransferase
subject: DDC 610 / Medicine & health
subject: NADPH oxidases
subject: Acetylation
subject: Histone deacetylases
subject: Histone acetyltransferases
subject: Sirtuin 1
subject: NADPH-Oxidase
subject: Resveratrol
subject: Acetyltransferasen
subject: Sirtuine

description: Oral treatment of apolipoprotein E-knockout (ApoE-KO) mice with the putative sirtuin 1 (SIRT1) activator resveratrol led to a reduction of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the heart. In contrast, the SIRT1 inhibitor EX527 enhanced the superoxide production in isolated human polymorphonuclear granulocytes. In human monocytic THP-1 cells, phorbol ester-stimulated superoxide production was enhanced by inhibitors of histone deacetylases (HDACs; including quisinostat, trichostatin A (TSA), PCI34051, and tubastatin A) and decreased by inhibitors of histone acetyltransferases [such as garcinol, curcumin, and histone acetyltransferase (HAT) Inhibitor II]. These results indicate that protein acetylation and deacetylation may represent crucial mechanisms regulating NADPH oxidase-mediated superoxide production. In cell-free systems, incubation of recombinant Rac1 with SIRT1 resulted in decreased Rac1 acetylation. Mass spectrometry analyses identified lysine 166 (K166) in Rac1 as a residue targeted by SIRT1. Deacetylation of Rac1 by SIRT1 markedly reduced the interaction of Rac1 with p67phox in in vitro assays. Computational modeling analyses revealed that K166 deacetylation of Rac1 led to a 5-fold reduction in its binding affinity to guanosine-5'-triphosphate, and a 21-fold decrease in its binding potential to p67phox. The latter is crucial for Rac1-mediated recruitment of p67phox to the membrane and for p67phox activation. In conclusion, both SIRT1 and non-sirtuin deacetylases play a role in regulating NADPH oxidase activity. Rac1 can be directly deacetylated by SIRT1 in a cell-free system, leading to an inhibition of Rac1-p67phox interaction. The downstream targets of non-sirtuin deacetylases are still unknown. The in vivo significance of these findings needs to be investigated in future studies.
title: Neumoperitoneo y neumatosis portal: cuándo preocuparse y cuándo no
Creators: name: Cárdenas del Carre, Agustín
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Pathology
subject: Acute
subject: Perception image
subject: Observer performance
subject: CT-High Resolution
subject: CT
subject: Education
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1) Revisar las causas más frecuentes de neumoperitoneo y neumatosis portal. 2) Aprender a considerar hallazgos concomitantes,
tanto radiológicos como clínicos,
para obtener una visión global de cada caso al que nos enfrentemos en la práctica...
Effectiveness of text messaging interventions on prevention, detection, treatment, and knowledge outcomes for sexually transmitted infections (STIs)/HIV: a systematic review and meta-analysis
Creators: name: Taylor, Darlene
name: Lunny, Carole
name: Lolić, Petra
name: Warje, Orion
name: Geldman, Jasmina
name: Wong, Tom
name: Gilbert, M.
name: Lester, Richard T.
name: Ogilvie, Gina
Publisher: name: BioMed Central
Year: 2019

description: Background: Rates of STIs continue to rise worldwide, and novel evidence-based interventions such as text messaging aimed at improving client services are needed. We conducted a meta-analysis to evaluate text messaging to support STI/HIV prevention and treatment interventions. Methods: We included articles that reported findings from randomized controlled trials (RTCs) involving adults and youth who were at risk of acquiring (or who currently had) a STI and/or HIV, a text message and comparator intervention, and reported provided outcome data on adherence to STI/HIV treatments. Articles were excluded if they were not published in English. We only included studies that have full-text publications so certainty and risk of bias assessments could be performed. Eight databases were searched to retrieve articles published between 1996 and March 2017. The Cochrane risk of bias tool was used and certainty of the evidence was assessed using GRADE. Effect estimates were pooled using a random effects model. Results: A total of 35 RCTs were found, 6 of which were considered at low risk of bias. Eight studies found an increased association using text messaging in appointments attended compared to standard care (OR 1.64, 95% CI 1.28 to 2.10). Participants receiving text messages had an increase in HIV testing compared to standard care (n = 6; OR 1.73, 95% CI 1.39 to 2.15). Ten text messaging RCTs measuring adherence using micro-electro-mechanical systems (MEMS) pill counts has a non-significant association (OR 1.17, 95% CI 0.95–1.45) while five studies measuring adherence by self-report was found to be significant (OR 1.64, 95% CI 1.28–2.11). Conclusions: The effectiveness of text message interventions is equivocal. While text messaging has the potential to enhance the delivery of STI/HIV interventions, program planners are encouraged to evaluate any SMS intervention to ensure it is achieving the desired result. Systematic review registration: PROSPERO CRD42013006503
Determining the probability of cyanobacterial blooms: the application of Bayesian networks in multiple
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Klimaänderung
Risikoanalyse

description: A Bayesian network model was developed to assess the combined influence of nutrient conditions and climate on the occurrence of cyanobacterial blooms within lakes of diverse hydrology and nutrient supply. Physicochemical, biological, and meteorological observations were collated from 20 lakes located at different latitudes and characterized by a range of sizes and trophic states. Using these data, we built a Bayesian network to (1) analyze the sensitivity of cyanobacterial bloom development to different environmental factors and (2) determine the probability that cyanobacterial blooms would occur. Blooms were classified in three categories of hazard (low, moderate, and high) based on cell abundances. The most important factors determining cyanobacterial bloom occurrence were water temperature, nutrient availability, and the ratio of mixing depth to euphotic depth. The probability of cyanobacterial blooms was evaluated under different combinations of total phosphorus and water temperature. The Bayesian network was then applied to quantify the probability of blooms under a future climate warming scenario. The probability of the "high hazardousŁ category of cyanobacterial blooms increased 5% in response to either an increase in water temperature of 0.8˚C (initial water temperature above 24˚C) or an increase in total phosphorus from 0.01 mg/L to 0.02 mg/L. Mesotrophic lakes were particularly vulnerable to warming. Reducing nutrient concentrations counteracts the increased cyanobacterial risk associated with higher temperatures.Quelle: http://www.esajournals.org
Characteristics of cognitive behavioral therapy for older adults living in residential care: Protocol for a systematic review
Creators: name: Chan, Phoebe
name: Bhar, Sunil
name: Davison, Tanya
name: Doyle, Colleen
name: Knight, Bob G.
name: Koder, Deborah
name: Laidlaw, Kenneth
name: Pachana, Nancy A.
name: Wells, Yvonne
name: Wuthrich, Viviana M.
Publisher: name: Swinburne
Year: 2024

description: Background: The prevalence rates of depressive and anxiety disorders are high in residential aged care settings. Older adults in such settings might be prone to these disorders because of losses associated with transitioning to residential care, uncertainty about the future, as well as a decline in personal autonomy, health, and cognition. Cognitive behavioral therapy (CBT) is efficacious in treating late-life depression and anxiety. However, there remains a dearth of studies examining CBT in residential settings compared with community settings. Typically, older adults living in residential settings have higher care needs than those living in the community. To date, no systematic reviews have been conducted on the content and the delivery characteristics of CBT for older adults living in residential aged care settings.
Objective: The objective of this paper is to describe the systematic review protocol on the characteristics of CBT for depression and/or anxiety for older adults living in residential aged care settings.
Methods: This protocol was developed in compliance with the recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Studies that fulfill the inclusion criteria will be identified by systematically searching relevant electronic databases, reference lists, and citation indexes. In addition, the PRISMA flowchart will be used to record the selection process. A pilot-tested data collection form will be used to extract and record data from the included studies. Two reviewers will be involved in screening the titles and abstracts of retrieved records, screening the full text of potentially relevant reports, and extracting data. Then, the delivery and content characteristics of different CBT programs of the included studies, where available, will be summarized in a table. Furthermore, the Downs and Black checklist will be used to assess the methodological quality of the included studies.
Results: Systematic searches will commence in May 2018, and data extraction is expected to commence in July 2018. Data analyses and writing will happen in October 2018.
Conclusions: In this section, the limitations of the systematic review will be outlined. Clinical implications for treating late-life depression and/or anxiety, and implications for residential care facilities will be discussed.
A new approach to prevent, diagnose, and treat hepatitis B in Africa.
Creators: name: Spearman, C Wendy
name: Andersson, Monique I
name: Bright, Bisi
name: Davwar, Pantong M
name: Desalegn, Hailemichael
name: Guingane, Alice Nanelin
name: Johannessen, Asgeir
name: Kabagambe, Kenneth
name: Lemoine, Maud
name: Matthews, Philippa C
name: Ndow, Gibril
name: Riches, Nicholas
name: Shimakawa, Yusuke
name: Sombié, Roger
name: Stockdale, Alexander J
name: Taljaard, Jantjie J
name: Vinikoor, Michael J
name: Wandeler, Gilles
name: Okeke, Edith
name: Sonderup, Mark
name: Network, Hepatitis B in Africa Collaborative
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Infectious Disease
subject: Infectious Disease
classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: Genetics & Genomics
subject: Genetics & Genomics

description: There are 82 million people living with hepatitis B (PLWHB) in the World Health Organization Africa region, where it is the main cause of liver disease. Effective vaccines have been available for over 40 years, yet there are 990,000 new infections annually, due to limited implementation of hepatitis B birth dose vaccination and antenatal tenofovir prophylaxis for highly viraemic women, which could eliminate mother-to-child transmission. Despite effective and cheap antiviral treatment which can suppress hepatitis B virus replication and reduce the risk of hepatocellular carcinoma (HCC), < 2% of PLWHB are diagnosed, and only 0.1% are treated. As a result, PLWHB are frequently diagnosed only when they have already developed decompensated cirrhosis and late-stage HCC, and consequently 80,000 hepatitis B-associated deaths occur each year. Major barriers include complex treatment guidelines which were derived from high-income settings, lack of affordable diagnostics, lack or insufficient domestic funding for hepatitis care, and limited healthcare infrastructure. Current treatment criteria may overlook patients at risk of cirrhosis and HCC. Therefore, expanded and simplified treatment criteria are needed. We advocate for decentralized community treatment programmes, adapted for low-resource and rural settings with limited laboratory infrastructure. We propose a strategy of treat-all except patients fulfilling criteria that suggest low risk of disease progression. Expanded treatment represents a financial challenge requiring concerted action from policy makers, industry, and international donor agencies. It is crucial to accelerate hepatitis B elimination plans, integrate hepatitis B care into existing healthcare programmes, and prioritize longitudinal and implementation research to improve care for PLWHB.
Supplementary document for Linear diattenuation imaging of biological tissues with near infrared Mueller scanning microscopy - 4886633.pdf
Creators: name: DUBREUIL, Matthieu
name: tissier, florine
name: Rivet, Sylvain
name: LE GRAND, Yann
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Figures
БИБЛИОТЕЧНАЯ ДЕЯТЕЛЬНОСТЬ ОБЩЕСТВА ПОПЕЧЕНИЯ О НАЧАЛЬНОМ ОБРАЗОВАНИИ (НА ПРИМЕРЕ Г. БАРНАУЛА АЛТАЙСКОГО КРАЯ)
Creators: name: Ю.А. Черниенко
name: Т.А. Курникова
Publisher: name: Мир науки, культуры, образования
Year: 2020
Subjects: Общество попечения о начальном образовании
библиотеки
народно-школьные библиотеки

description: В статье раскрывается деятельность Общества попечения о начальном образовании в контексте истории создания и развития публичных провинциаль ных библиотек на территории г. Барнаула. Книга, библиотека, чтение позволяют осуществлять передачу информации, и во многом качество образования, успех самообразования будут зависеть именно от них. Исторически в формировании образовательной среды региона особую роль сыграла общественная инициатива. В то же время публичная библиотека в Сибири – переосмысленный опыт организации библиотек в Европейской части России. Благодаря деятельности П.И. Макушина и его последователей, в частности В.К. Штильке, народная библиотека за Уралом – не просто точная копия европейской, а творческое ее переосмысление. Традиции, заложенные Обществом и В.К. Штильке, продолжены в деятельности современных библиотек города.
Understanding the role of HIF-2alpha in human cancers
Creators: name: Franovic, Aleksandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.

description: Cancer development is a multi-step process, driven by a series of genetic and environmental alterations, which endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signal autonomy, the first hallmark of malignancies, can be acquired through multiple genetic mutations that activate an array of complex, cancer-specific growth circuits. The superfluous nature of these pathways is thought to limit therapeutic approaches targeting cell proliferation and so this strategy is often abandoned in favor of inhibiting more systemic hallmarks. Here, we report that genetically diverse cancers converge at a rate-limiting oncogenic axis instigated by HIF-2alpha, a component of the oxygen-sensing machinery. Inhibition of HIF-2alpha prevents the in vivo growth and tumorigenesis of a panel of highly aggressive human cancer cell lines, irrespective of their mutational status and tissue of origin. We further offer mechanistic evidence that HIF-2alpha exerts its proliferative effects through the translational upregulation and/or activation of select receptor tyrosine kinases, including the EGFR and IGF-IR, and their downstream signaling pathways. Consistently, silencing these receptors or blocking upstream ligand processing events phenocopies the loss of HIF-2alpha activity, abrogating the serum-independent growth of cancer cells in culture and their tumor formation in athymic mice. Taken together, the data presented in this thesis reveal an important role for HIF-2alpha in promoting the persistent proliferation of neoplastic cells and suggest that tumors do share common growth elements that can serve as drug targets in the treatment of a wide range of human cancers.
title: Evolución en tres años de la Radiografía de Tórax en pacientes pediátricos con Fibrosis Quística. Correlación con el estudio espirométrico y datos clínicos.
Creators: name: Rayón-Aledo, Jose Carlos
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Infection
subject: Metabolic disorders
subject: Genetic defects
subject: Efficacy studies
subject: Comparative studies
subject: Treatment effects
subject: Conventional radiography
subject: Thorax
subject: Paediatric

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
En pacientes pediátricos con fibrosis quística: - Determinar la evolución de la radiografía de tórax,
según la clasificiación de Brasfield,
en un periodo de tres años. - Estudiar si la evolución de las alteraciones observadas en la...
СОПРОВОЖДЕНИЕ ЛИЧНОСТНОГО САМООПРЕДЕЛЕНИЯ БУДУЩИХ ПЕДАГОГОВ КАК ФАСИЛИТИРУЮЩАЯ ПРАКТИКА
Creators: name: Е.В. Неумоева-Колчеданцева
Publisher: name: Мир науки, культуры, образования
Year: 2020
Subjects: педагогическое сопровождение
личностное самоопределение
социокультурное опосредование (медиация)
педагог-фаси литатор
фасилитирующая практика

description: Статья посвящена концептуальному обоснованию педагогического сопровождения личностного самоопределения будущего педагога как фасилити рующей практики. Личностное самоопределение будущего педагога – относительно новый «предмет» сопровождения в профессиональном образовании, актуальность которого связана с индивидуализацией образования. Деятельностная трактовка личностного самоопределения («деятельность самоопреде ления») позволяет рассматривать педагогическое сопровождение как релевантную ему гуманитарную практику, целевое назначение которой заключается в социокультурном опосредовании личностного самоопределения с использованием арсенала известных медиаторов (знак, слово, действие). При этом гуманитарный характер сопровождения предполагает, что социокультурные медиаторы, а также психотехнический аспект сопровождения «вторичны» по отношению к личности педагога-фасилитатора. Фасилитирующая суть сопровождения «обеспечивается» и реализуется «посредством» личности педа гога, которая рассматривается как высоко ресурсированная личность, стимулирующая процессы личностного самоопределения студентов. Понимание фасилитирующей сути сопровождения и деятельностного характера личностного самоопределения позволяет дать позитивную характеристику действий педагога-фасилитатора: стимулирование базовых процессов самоопределения, «пробующей» активности личности в квазирежиме и в широком жизненном контексте.
title: Nuevas técnicas de uretrosonografía
Creators: name: Berná Mestre, Juan de Dios
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Obstruction / Occlusion
subject: Motility
subject: Dilatation
subject: Cystography / Uretrography
subject: Technical aspects
subject: Contrast agent-other
subject: Ultrasound
subject: Contrast agents

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Describir una nueva técnica para realizar uretrosonografía masculina en adultos: EL MÉTODO CLAMP,
que se divide en dos procedimientos: 1.- URETROSONOGRAFÍA RETRÓGRADA (USR),
para evaluar anomalías de la uretra anterior. 2.- URETROSONOGRAFÍA...
Supplementary document for Linear diattenuation imaging of biological tissues with near infrared Mueller scanning microscopy - 4886633.pdf
Creators: name: DUBREUIL, Matthieu
name: tissier, florine
name: Rivet, Sylvain
name: LE GRAND, Yann
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Figures
СРЕДСТВА ОБУЧЕНИЯ В ПРЕПОДАВАНИИ АНАТОМИИ ЧЕЛОВЕКА
Creators: name: М.А. Майорова
name: А.А. Болотская
name: В.А. Кудряшова
name: М.В. Оганесян
name: Н.А. Ризаева
name: В.Н. Николенко
Publisher: name: Мир науки, культуры, образования
Year: 2020
Subjects: анатомия человека
анкетирование
средства обучения
средства новых информационных технологий

description: Статья посвящена средствам обучения (СО) и методике их использования в процессе преподавания анатомии человека в медицинском университете. Целью работы является исследование особенностей использования традиционных и компьютерных СО в аудиторной, иной контактной, а также работе, выполняемой студентами-медиками самостоятельно в процессе изучения базовой дисциплины анатомии человека. Предложены рекомендации по использованию средств обучения на занятиях по анатомии человека. Они базируются на результатах анкетирования студентов после экзамена в конце семестра, отзывах обучающихся, а также опыте работы преподавателей кафедры анатомии человека Сеченовского университета. В процессе преподавания дисциплины «Анатомия человека» в вузе целесообразно использовать комплексы средств обучения, включающие не только традиционные СО (схемы, таблицы, анатомические рисунки и др.), но и интерактивные мультимедийные обучающие модели, средства новых информаци онных технологий (СНИТ), в частности анатомический стол. Виртуальная анатомия эффективно помогает студентам при изучении анатомических органов и систем, предлагая изображения органов в нескольких плоскостях, позволяя студентам рассматривать все анатомические структуры в различных аспектах (КТ, МРТ, 3Д). Изучение «Анатомии человека» с помощью СНИТ позволяет обучающимся уяснить сложнейшие теоретические вопросы по анатомии; побу ждает студентов по-разному исследовать и препарировать модель человека.