cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese
Creators: name: Urban, Brittney Marie
Publisher: name: University of Utah
Year: 2015
Subjects: Adiponectin
Breakfast
Breastfeeding
Leptin
Nutrition
Obesity

description: Adipokines, including adiponectin and leptin, are secreted by adipose tissue. With an increase in fat mass, concentrations of adiponectin decrease and leptin increase, altering the adiponectin/leptin (A/L) ratio. A/L ratio is associated with metabolic dysfunction, as are multiple diet factors including breastfeeding in infancy and breakfast intake. However, it is not known whether these diet factors are related to A/L ratio, and if they will protect against metabolic dysfunction in a population at an increased risk. The purpose of this study was to investigate whether breastfeeding duration in infancy and current breakfast frequency are associated with A/L ratio and metabolic dysfunction in children and adolescents with obesity. The study cohort consisted of obese (body mass index ≥ 95th percentile) children and adolescents (n = 100, 46M). Fasting blood samples were taken to measure high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, insulin, glucose, adiponectin, and leptin levels. Weight, height, and blood pressure were also assessed. Breastfeeding history was obtained through the National Health and Nutrition Examination Survey of 2003-2004, and breakfast frequency was reported through the Gold Medal School Parent Questionnaire administered to parents. Of the 100 participants, 82% were breastfed as infants. Among the breastfed, 66% (n = 54) were breastfed for ≥ 6 months and 62% (n = 54) were breastfed exclusively for ≥ 6 months (4 parents could not recall duration of exclusive breastfeeding). Of the breakfast responses collected (n = 46), most participants (59%, n = 27) reported consuming breakfast every day. There was no association between these diet factors and A/L ratio or the presence of metabolic dysfunction. Differences in A/L (p = 0.02) and leptin (p = 0.009) were noted between categorical breakfast frequencies when gender was controlled for, and there was a significant difference in BMI between categorical breakfast intakes (p = 0.02). There were no significant relationships in the linear model of breakfast. No association between A/L ratio and metabolic dysfunction was observed. In conclusion, breastfeeding duration and breakfast frequency do not appear to influence A/L ratio or metabolic dysfunction in this population of obese children and adolescents.
Two new steroid sulfates from a cheilostome bryozoan, Calyptotheca sp.
Creators: name: Roy, Sona Rani
name: Minei, Alisa
name: Ahmadi, Peni
name: Hermawan, Idam
name: Kurnianda, Viqqi
name: Dick, Matthew H.
name: Tanaka, Junichi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Plant Biology

description: Two new steroid sulfates 1 and 2 were obtained from a lipophilic extract of an undescribed bryozoan species in the genus Calyptotheca. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and chemical modifications. Steroids 1 and 2 exhibited moderate cytotoxicity at IC50 54 and 30 µM, respectively, against NBT-T2 cells.
Structural studies of flagellar motors and uroporphyrinogen III synthase
Creators: name: Mathews, Michael A. A.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Aanalysis
subject: Proteins
subject: Microbiology
subject: FOS: Biological sciences

description: The focus of this dissertation is structural evaluation of proteins. The first three chapters relate to the proteins of the bacterial flagellar motor. The final four chapters are pertinent to an enzyme within the porphyrin biosynthetic pathway. I have used the tools of molecular biology, biochemistry, and x-ray crystallography to probe these proteins.  Through the design and cloning of mutants, as well as binding studies between mutant proteins, I have mapped the regions of the protein FliM that are important in binding to the other flagellar proteins FliG, FliN, and CheY. Analytical ultra-centrifugation has been used to look at the possible solution states of FliM and FliN and perhaps shed some light on their states before being incorporated into the motor. X-ray protein crystallography is being attempted to determine the atomic structure of several of these flagellar proteins to better understand their function and mechanism of action.  X-ray crystallography was used to determine the atomic structure of the fourth enzyme in the porphyrin biosynthetic pathway, uroporphyrinogen III synthase. An introduction to this enzyme is presented in Chapter 4, an overview of the method of x-ray crystallography comprises Chapter 5, the structure and discussion of the enzyme enzyme is in Chapter 6, and future directions for this research are found in Chapter 7.
Newboulasides A and B, two new caffeic acid glycosides from Newbouldia laevis with α-amylase inhibitory activity
Creators: name: Mbagwu, Ikechukwu Sonne
name: Akah, Peter Achunike
name: Ajaghaku, Daniel Lotanna
name: Ike, Jeremiah Chibueze
name: Okoye, Festus Basden Chiedu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: Chemical investigation of the ethanol extract of the leaves of Newbouldia laevis (P. Beauv) led to the isolation of two new caffeic acid glycosides, Newboulasides A (1) and B (2). The structures of these compounds were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. The extracts and fractions and the isolated compounds were evaluated for their inhibition of α-amylase enzyme activity. The extract showed inhibition of α-amylase activity with IC50 value of 102.91 µg/mL, while the isolated compounds (1 and 2) exhibited pronounced inhibition with IC50 values of 4.95 and 4.44 µg/mL respectively, comparable to the standard – Acarbose with IC50 value of 4.05 µg/mL. Our findings demonstrated that the inhibition of α-amylase activity may be part of the mechanisms through which N. leavis exhibits antidiabetic effect.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.09.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Design of a microcamera using a silicon based closed-loop microdeployable structure
Creators: name: Boutte, Ronald Wayne
Publisher: name: University of Utah
Year: 2012
Subjects: Micromechanics
Miniature cameras

description: The ability of a MEMS device to stretch a flexible lens (similar to a crystalline  lens of the human eye) has far reaching consequences in the miniaturization  of current commercial optical systems. A closed-loop mierodeployable structure  was designed and surface micromachined in Sandia's SUMMiT-Vâ„¢ process as a  proof-of-concept for conversion of rotational to radial motion. This same basic  mierodeployable concept was then modified to produce two key components in  a microscale camera: a microautofocus mechanism and a microaperture. The inicroautofocus  component couples a polymer lens to the closed-loop mierodeployable;  as it deploys open, it stretches the polymer lens radially, at eight fixed areas, around  the circumference of the lens. The lens deformation in turn causes a focal plane  change. The ability to change the focal plane is advantageous to portable digital  imaging devices such as the cell phone camera and the mini-digital camera.  Further adaptation of the original mierodeployable by the placement of solid  plates instead of bar linkages produces a microaperture, which has a stop range of  7/2.8 to / / 5 . 6 . Each of these components is integrated at the die level with a digital  imaging sensor to produce a mieroeamera of dimensions 1.8mm x 2.0mm x 2.0mm.
Endertiins A-B, two lanostane triterpenoids from the fruit bodies of the mushoom Humphreya endertii
Creators: name: Quang, Dang Ngoc
name: Le Duc Long
name: Tung, Nguyen Quang
name: Thanh, Nguyen Ngoc
name: Le Xuan Tham
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Two new lanostane triterpnenoids named endertiins A and B (1 and 2) together with two known compounds as ganodecalone A (3) and ergosterol (4) have been successfully isolated from the cultivated fruit bodies of the mushroom Humphreya endertii Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopic analyses. In addition, endertiins A and B (1 and 2) were evaluated their cytotoxicity against two cancer cell lines, MCF7 (human breast carcinoma) and LU (human lung carcinoma). The result showed that endertiin A (1) could inhibit the growth of MCF-7 cells with its IC50 value of 71.16 ± 6.25 µg/ml.
Fotografische Sonnenaufnahme und zugehörige Zeichnung, unnummeriert, einen Zürcher Lückentag ergänzend.
Fotoabzug und durchgepauste Zeichnung der Aufnahme von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.09.1968, fotografiert von John S. Korintus
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Der Abzug ist auf der Rückseite mit genauen Angaben versehen. Flecken und Fackelflächen sind auf das Pauspapier übertragen. Im Jahresbericht für das vorliegende Jahr ist John S. Korintus nicht erwähnt
The effects of partial ionization on magnetic flux emergence and solar eruptive events
Creators: name: Chouliaras, Georgios
Publisher: name: The University of St Andrews
Year: 2025
Subjects: Magnetic flux emergence
Partial ionization
Heliophysics
Solar eruptions
Solar jets
MHD simulations

description: The process of magnetic flux emergence is closely linked to the formation of solar active regions, which are the main sites for most solar eruptions. The Sun’s lower atmosphere and a part of its upper convection zone are partially ionized. In this thesis, we modified the one-fluid magnetohydrodynamic equations to include the effects of partial ionization. Our work involves comparing two simulation scenarios: one with a fully ionized plasma (FI) and the other with a partially ionized plasma (PI). We analyzed and compared these scenarios in both an unmagnetized solar atmosphere and a magnetized solar atmosphere. Our analysis shows that in the PI case, less dense plasma rises more easily to the photospheric layer than in the FI case. The PI plasma changes the structure of the emerging magnetic field, shaping bipolar regions differently and causing the magnetic field to expand upwards sooner. We have found that partial ionization reduces cooling during adiabatic expansion but does not heat the atmospheric plasma. In our 3D experiments, we have found that PI does not prevent coronal unstable magnetic structures from erupting into the outer solar atmosphere. The failed emergence of the flux tube axis in the PI case created differences in the dynamical evolution of the magnetic field in the solar atmosphere compared to the FI case. We also observed differences in temperature, density, and vertical velocity profiles during eruptions, highlighting the impact of partial ionization in the lower atmosphere and upper convection zone. Comparing PI and FI simulations in a magnetized corona, we found that the first reconnection jet is a multithermal jet and is slower, cooler, and less dense in PI than in FI. For inverted-Y-shaped standard jet we find that the PI jet is less hot, less dense, but faster than the FI jet. We have found the presence of mini-filament-structures in both simulations. We have found that PI have more energetic blowout jets. To conclude this PhD thesis provided new results and shed light on the effects of the partially ionized plasma on magnetic flux emergence and solar eruptive events.
Studies on staphylococcus aureus with reference to coagulase activity
Creators: name: Anselmo, Carl Ross
Publisher: name: University of Utah
Year: 2012
Subjects: Coagulase
Staphylococcus aureus

description: As observed in these studies, mice in the age range of 6-17 days of age were more susceptible to the injection of staphylococcal supernatants than were older mice.  Freezing and thawing the storage of a staphylococcal broth culture at -26° C for seven months did not affect the coagulase titers nor the toxic activity of this culture.  It was observed that filtration of staphylococcal broth cultures through Seitz and Mandler filters removed coagulase, but did not affect the toxic activity of these cultures.  Millipore filtration did not remove coagulase.  Prolonged incubation of Staph. aureaus cultures in the present of increased carbon dioxide favored the production of toxin rather that coagulase.  Lethality for suckling was sue to the presence of staphylococcal exotoxin in the cultures and in cell free filtrates rather than coagulase.  In addition, cell free filtrates were more lethal than were the cultures which contained organisms.  Exposure to boiling temperature of cell free filtrates, prepared from cultures of Staph. aureaus strains 15 and 17, did not destroy the toxic activity of these filtrates as it did with the filtrates of strains 5 and 13.  The results obtained with strain 17, a turkey isolate, resembled those of the human strain 15.  Cell free filtrates of both strains were quite toxic; however, the toxins of strain 15 appeared to be more heat stable than those of strain 17.  No significant immunological difference was shown between the heat labile and the heat stable fractions of staphylococcal exotoxin.  In addition, mice injected with a mixture of cell free filtrates plus homologous or heterologous antiserm were not protected from the toxic activity of these filtrates.  A positive coagulase test was not obtained with a suspension of Staph. aureus strain 15 heated at 56°C for 75 minutes.  However, this treatment did not destroy the ability of this organism to produce coagulase.  In the experiment to determine if coagulase in produced in vivo, coagulase could not be detected in the supernatant fluid of a suspension of ground mouse muscle tissue.
Sonnenfleckenzeichnung Nr. 22958.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.12.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Interactions of D1-dopamine receptors with functionally distinct NMDA receptors in striatum
Creators: name: Chapman, David E.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Cell Physiology
subject: Dopamine Agents
subject: Physiology
subject: FOS: Biological sciences

description: The striatum is the main input nucleus of the basal ganglia, a group of subcortical structures critically involved in the control of movement and cognitive function. This structure receives excitatory glutamate input and modulatory dopamine (DA) input. How these two neurotransmitter systems interact in striatal efferent neurons largely governs basal ganglia activity and function. The N-methyl-D-aspartate receptor (NMDAR) is a subtype of glutamate-gated ion channels which is comprised of multiple and different subunits. In striatum, the NR2A subunit of the NMDAR shows a distinct medial-to-lateral gradient, with greater expression laterally. Varied levels of NR2A subunit in expression systems and across development give rise to NMDARs with different biophysical and pharmacological properties. However, whether such differences occur in the same neuronal type at the same developmental timepoint in different regions of the striatum has not been determined. The studies presented in this dissertation therefore were designed to test the hypothesis that there are functionally distinct NMDARs in dorsolateral versus ventromedial striatum and that these receptors are differentially modulated by D1-DA receptor activation. The results demonstrate that NMDARs in different regions of striatum are functionally distinct. The data also suggest that these NMDARs may be differentially affected by D1-DA receptor activation. Finally, the data show that a partial loss of striatal DA alters D1-DA receptor signaling in striatum, including differential modulation of NMDARs in ventromedial striatum. The data presented in this dissertation are the first to show electrophysiologically that NMDARs in striatum are functionally distinct and that striatal efferent neuron function is altered as a consequence of partial DA loss. This information may ultimately lead to improved treatments for long-term consequences of psychostimulant abuse and other basal ganglia disorders, including Parkinson's disease and schizophrenia.
Geniatosoma lindemannae
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Geniatosoma
Geniatosoma lindemannae

description: § Geniatosoma lindemannae (Frey, 1976)
Geniates lindemannae Frey 1976b: 354 (Brazil (NA))
= Geniatosoma fernandezi Martínez 1977: 15 (Brazil (NA)) - Jameson and Hawkins 2005: 37 (syn. nov.)
Distribution. Brazil (NA): Frey 1976b: 354 (as Geniates lindemannae) (NA); Martínez 1977: 15 (as G. fernandezi) (NA); Lacroix 2000: 202 (as G. fernandezi) (NA); Jameson and Hawkins 2005: 37. Venezuela (EO): Jameson and Hawkins 2005: 37 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 123, DOI: 10.5281/zenodo.3678492
Structural basis of DNA binding and autoinhibition for the eukaryotic transcription factor ETS-1
Creators: name: Petersen, Jeannine Marie
Publisher: name: University of Utah
Year: 2012
Subjects: Gene Expression Regulation
Eukaryotic Cells

description: The ets family of transcription factors represents a paradox in the study of DNA binding proteins. How can regulatory proteins that share the same DNA binding properties exert the distinguishable effects necessary to execute gene regulation? As a framework for addressing this question, the molecular basis of DNA binding for Ets-1, the founding member of the ets family, was determined. Two N-terminal deletion polypeptides of Ets-1 that retained either DNA binding (DeltaN331) or DNA binding and autoinhibition (DeltaN280) were utilized for these studies. Determination of the nuclear magnetic resonance (NMR) secondary structure for the Ets-1 DNA binding domain (ETS domain) classified the ets proteins into a structural family of DNA binding proteins termed the winged helix-turn-helix (wHTH) superfamily. Tertiary structure analysis of the Ets-1 ETS domain confirmed the wHTH DNA binding motif and showed that the ETS domain is composed of a three-helix bundle packed against a four-stranded antiparallel beta-sheet. A helix-turn-helix DNA binding motif is found within the three-helix bundle. Insight into the mode of DNA binding utilized by Ets-1 and other ets proteins was obtained by comparison to previously described cocrystal structures for wHTH proteins.  Additional insights into ets protein DNA binding specificity come from structural studies of Ets-1 autoinhibition. Quantitative DNA binding assays defined a minimal region required for Ets-1 DNA binding inhibition. Thermal denaturation studies demonstrated that the functions of inhibition and DNA binding are coupled within a single structural domain. NMR secondary structure analysis confirmed this finding and showed that the Ets-1 inhibitory domain is composed of four alpha helices; two alpha helices in the N-terminal inhibitory region, one alpha helix in the C-terminal inhibitory region, and helix one in the ETS domain. Furthermore, these studies demonstrated that the alpha helices within the N- and C-terminal inhibitory regions of Ets-1 are structurally coupled to each other and to the ETS domain. Upon DNA binding, a unique conformational change involving unfolding of an alpha helix within the N-terminal inhibitory region was observed. This provided evidence that disruption of the inhibitory module occurs on DNA binding. A model is presented whereby interactions with a protein partner could serve to stabilize the de-repressed Ets-1 conformation. Thus, specificity of binding for members of the ets family that display autoinhibition of DNA binding could be determined via interaction with a protein partner. These findings provide important insight into the molecular basis of cooperative partnerships between DNA binding proteins and the conformational changes that regulate transcription factor function.
Sonnenfleckenzeichnung Nr. 22941.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.11.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Nonlocal plasticity, instability, and well-posedness of the elastic-plastic initial-boundary value problem
Creators: name: Burghardt, Jeffrey A.
Publisher: name: University of Utah
Year: 2012
Subjects: Flow rule
Instability
Material point method
Nonassociated
Nonlocal plasticity
Plasticity

description: Traditional associative plasticity theories have previously been shown to be incompatible with experimental data. For this reason, a nonassociative plasticity theory is  commonly adopted. Nonassociative plasticity theories are prone to several forms of instability that result in the governing equations becoming ill-posed. Two of  these instabilities are discussed: the localization instability and the Sandler-Rubin instability, which is a nonphysical instability that may occur with any degree of  nonassociativity.   The primary purpose of this dissertation is to describe how traditional nonassociative plasticity theory can be reformulated to eliminate the  Sandler-Rubin instability while maintaining agreement with experimental data. Numerical and analytical techniques are used to investigate the effects of three nontraditional plasticity models on the existence of the Sandler-Rubin instability: viscoplasticity, incrementally non-linear plasticity, and nonlocal plasticity. Of these, it is shown that only incremental nonlinearity eliminates the instability while maintaining agreement with existing experimental data. Standard laboratory tests cannot detect nonlinearity in a material's incremental response. For this reason a new experimental method and a new data analysis technique are presented and used to validate incrementally nonlinear plasticity theory. The new technique uses a cyclic load path and an interpolation scheme to infer the material response to several loading directions at the same material state. This new technique was used to study the incremental response of aluminum 6061-T0. The new technique suggests that there is significant nonlinearity in the incremental response of this material.  Though it will be demonstrated that the Sandler-Rubin instability is not eliminated with nonlocal theory, this theory is nevertheless well established at regularizing  otherwise ill-posed localization problems. Few efficient numerical schemes exist for solving the equations of nonlocal plasticity. Schemes have previously been developed for solving these equations as part of a finite-element or element-free Galerkin method, but no general convergence criterion had been developed for these methods. A new numerical scheme for solving these equations using the material point method (MPM)  is presented. The new scheme uses the MPM background grid for particle-to-particle communication, and results in a simple, matrix-free algorithm. A convergence crite-  rion derived for the new method is furthermore shown to be applicable to some of the methods developed by other researchers.
Serum calcium and blood loss at delivery
Creators: name: Nickerson, Carolyn Janice Beck
Publisher: name: University of Utah
Year: 2012
Subjects: Childbirth
Anemia
Calcium in the body

description: The purpose of the study was to investigate the relationship between predelivery serum calcium values and blood loss at delivery as reflected by changed in selected hematologic values from predelivery to second postpartum day.  Twenty-nine women who delivered at the Shiprock Indian Health Service Hospital and 25 women who delivered at Hill Air Force Base Hospital were studied.  Each subject had a total serum calcium level determined prior to delivery.  Hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were measured for each subject prior to delivery and again on the second postpartum day.  Changes in these hematologic values were interpreted as indices of blood loss at delivery.  Pearson product-moment correlations were calculated to test the hypothesized relationship between serum calcium and changes in the hematologic values.  No statistically significant correlations were observed.  Previously reported association of blood loss with maternal age, parity, length or labor, and infant weight are supported by this study.  Although norms do no exist for drops in hematocrit and hemoglobin per volume of blood loss for parturient women, the magnitude and frequency of drops in these values observed in this study speaks to the excessive loss of blood by women who participated in the study.  Contrary to the expectation of the investigator, the Navajo women form Shiprock did not have serum calcium levels lower than the primarily Caucasian sample for Hill; neither did the Navajo subjects lose more blood at delivery than the subject from Hill.  Initially, it was assumed that the Navajo tendency to lower serum calcium levels and greater blood loss at delivery were related to racial differences.  Observation of the same tendencies among the subjects from Hill suggest that these trends to lower serum calcium and excessive blood loss at delivery are a function of the interaction of other variables, perhaps socioeconomic or nutritional status.
Sonnenfleckenzeichnung Nr. 22949.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.11.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Diacylglycerol signaling and metabolism
Creators: name: Bunting, Michaeline
Publisher: name: University of Utah
Year: 2012
Subjects: Lipids
Proteins

description: Diacylglycerol is a key intracellular messenger in many physiological responses. It is both an activator of protein kinase C and a precursor in the synthesis of complex lipids. The dysregulated production of diacylglycerol has also been demonstrated in pathological responses. Clostridium perfringens type A, the etiologic agent of gas gangrene, produces an exotoxin with phospholipase C activity, alpha toxin, that degrades phosphatidylcholine to diacyglycerol and phosphorylcholine. Alpha toxin treated endothelial cells contained elevated levels of diacylglycerol and produced platelet-activating factor and prostacyclin. Furthermore, the stimulated endothelial cells became adhesive to neutrophils by a mechanism that was mediated by P-selectin and platelet-activating factor. These endothelial cell responses appeared dysregulated and may contribute to both the localized and systemic manifestations of gas gangrene. Diacylglycerol lipase catalyzes the deacylation of diacylglycerol at the sn-1 position and is the first step in the release of arachidonic acid from arachidonate containing diacylglycerols. The primary diacylglycerol lipase from human platelets was purified and demonstrated to be identical with the human lysosomal acid lipase. Additionally, the lysosomal acid lipase exhibited diacylglycerol transacylase activity. Wolman's fibroblasts which lack lysosomal acid lipase had undetectable levels of diacylglycerol lipase and diacylglycerol transacylase activity. Furthermore, these cells contained normal levels of endogenous diacylglycerol and metabolized exogenous diacylglycerol similar to control cells. This study represents the first complete purification of a diacylglycerol lipase or diacylglycerol transacylase activity from mammalian cells. Diacylglycerol can also be phosphorylated by diacylglycerol kinase in an ATP dependent reaction. A novel 3.5 kilobase cDNA that encodes the human diacylglycerol kinase$/zeta$ was isolated from an endothelial cell library. The corresponding mRNA is highly expressed in brain, skeletal muscle, and heart. Diacylglycerol kinase$/zeta$ contains two zinc finger motifs, a sequence that is similar to the phosphorylation site domain of the myristoylated, alanine-rich C-kinase substrate, an ATP binding consensus site, and four carboxy-terminal ankyrin repeats. The kinase activity displayed stereoselectivity for 1,2 diacylglycerol but did not exhibit any specificity for molecular species of long chain diacylglycerols.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.12.1968, erstellt am Sonnenobservatorium der Universität Teheran
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Zeichnung von Sonnenflecken (Bleistift und Farbstift), erstellt als Projektionsbildzeichnung in Teheran.
Unter Umständen im Zusammenhang mit Beobachtungen des Air Weather Service der U.S. Air Force im Auftrag des NASA Controll Centers in Houston erstellt. Instrument: unbekannt.
Instrument unbekannt
Sonnenfleckenzeichnung Nr. 22863.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.08.1968, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Binding mechanisms of immobilized heparin with blood proteins
Creators: name: Byun, Youngro
Publisher: name: University of Utah
Year: 2012
Subjects: Heparin
Blood proteins

description: Heparin is a heterogeneous polysaccharide the prolongs the clotting time of blood by preventing the fibrin formation. Previous research has demonstrated that heparin immobilized onto a polymer substrate using grafted hydrophilic spacer improved the blood compatibility in in vitro, ex vivo, and in vivo experiments. In this current research, the previous observations were confirmed and explained by studying the binding kinetics of immobilized heparin with antithrombin III (ATIII), thrombin, and fibronectin, both under static and flow conditions.  Heparin, with its high affinity for ATIII and monodispersed molecular weight (mw 6,000), was bound to polyethylene oxide (PEO, mw 3,400) which was grafted onto poly(styrene-co-p-aminostyrene). Heparin was immobilized by 1:1 binding with the PEO spacer, resulting in 16.2 % bioactivity, compared to that of free heparin.  For spacer-immobilized heparin, the dominant pathway in the anticoagulant processes involved spacer-immobilized heparin initially binding to ATIII, thereby accelerating the binding of thrombin to ATIII. Directly-immobilized heparin, however, bound only to thrombin. So, the mechanism of immobilized heparin was changed by spacer. The TAT complex was then dissociated from the spacer-immobilized heparin quickly, thereby recovering the bioactivity of heparin.  The effect of fibronectin on the binding of immobilized heparin with ATIII depended upon the concentration of fibronectin in bulk. Fibronectin could be displaced by ATIII on the heparin binding site at the plasma concentration.  To study flow effect on the reactions of immobilized heparin, the dissociation rate of TAT complex and the mechanism of protein binding to immobilized heparin were determined by comparing the theoretical data in numerical simulation with the parallel experimental data. The dissociation rate constant of the TAT complex from spacer-immobilized heparin was gradually increased with increasing flow rate, and the binding of thrombin to heparin-ATIII complex at the surface was controlled by diffusion. Spacer-immobilized heparin reacts with ATIII and thrombin via the main pathway in low flow rates as mentioned above. Therefore, spacer-immobilized heparin surfaces can work at low flow rates as well as high flow rates.
Supported decision-making and the Disability Royal Commission
Creators: name: Then, Shih-Ning
name: Bigby, Christine
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 480707
subject: Welfare, insurance, disability and social security law
classificationCode: 39
subject: Education
classificationCode: 4409
subject: Social work
classificationCode: 3904
subject: Specialist studies in education
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 420318
subject: People with disability
classificationCode: 44
subject: Human society

description: Throughout its proceedings and in its Final Report, the Royal Commission into Violence, Abuse, Neglect and Exploitation of People with Disability gave considerable prominence to supported decision-making as a means for achieving the human rights of people with disabilities. It sought input on supported decision-making from people with lived experience, roundtables, public hearings, and commissioned independent research on supported decision-making and proposals for reform. Practical challenges raised at the roundtables and by witnesses included the resources needed for education, training, and capacity building, and the challenge of finding supporters for people who were isolated. Evidence was given that legal reform was only one aspect of what was needed to embed supported decision-making into sectors and services to improve the lives of people with cognitive disabilities. The Commission’s Final Report endorsed a set of national supported decision-making principles, with many of these principles underpinned by the evidence received and commissioned research. However, overall, the Commission’s recommendations were overly focused on reform of guardianship and administration systems, and implementation guidance was lacking. The Commission also missed an opportunity to recommend legislative and practice reform beyond guardianship systems, into multiple services and sectors including the National Disability Insurance Scheme, the health system, and the public sector more widely.
Sonnenfleckenzeichnung Nr. 22936.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.10.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen
Thymus vulgaris L. essential oils from Emilia Romagna Apennines (Italy): phytochemical composition and antimicrobial activity on food-borne pathogens
Creators: name: Tardugno, Roberta
name: Serio, Annalisa
name: Purgatorio, Chiara
name: Savini, Vincenzo
name: Paparella, Antonello
name: Benvenuti, Stefania
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Between Modena and Bologna Apennines (Italy), several agricultural farms have recently been dedicated to the cultivation of autochthonous aromatic plants as primary cultivation or to complement other crops. In this study, the chemical composition of Thymus vulgaris L. essential oils (EOs) from this region was evaluated by means of gas-chromatographic analysis. Three different mulching techniques, in particular, soil coverage with grass, mulch with plastic film and with straw were investigated. The results highlighted that mulching techniques influenced the composition of the analysed EOs. All the EOs exerted good antimicrobial activity against clinical and food strains of the pathogen Listeria monocytogenes, with differences related to the composition. The EO obtained from plants covered with grass showed the best results, having MIC ≤ 2.5 µL/mL, and being able to inhibit also antibiotic-resistant strains, thus confirming that soil coverage with grass influences the composition and also the biological activity of Thymus vulgaris EO.
Possible overwintering reservoirs and experimental epidemiology of western equine encephalitis virus
Creators: name: Stanton, Glen John
Publisher: name: University of Utah
Year: 2012

description: The experimental and field evidence presented in this thesis relative to the possibility that snakes are important in the over-wintering mechanism of WEE virus in nature are as follows:  1.  Virus titers in snakes were found to be sufficiently high to infect a significant percentage of mosquitoes feeding on them.  The ID50 for a mosquito was found to be approximately 10(5.2)PFU/ml.  2. The duration of viremia in these animals was considerably longer, even at room temperature, than has been found in most other animals.  3. Under the conditions of the experiments, two infective mosquitoes were sufficient to infect certain snakes.  4. Virus was isolated from at least one snake captured in nature during the spring, when recent infection by C. tarsalis was impossible.  5. Possible evidence for a cycling phenomena of WEE virus in the blood of snakes kept at room temperature was discussed.  In preliminary studies involving experimental infection of bats with WEE virus it was not found that under hibernating conditions, one species of bat, P. townsendii, would maintain WEE virus in the circulating blood for at least 36 days and in tissues for a least 45 days.
[Ansicht von Pappenheim]
Creators: name: Röckelein, J.
Publisher: name: [s.n.]
Year: 1880

description: Es handelt sich bei der Aufnahme um einen Albuminabzug
description: Titel gemäss handschriftlicher Notiz auf der Rückseite der Unterlage
description: Der Abzug ist auf Karton montiert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.09.1968, erstellt am Sonnenobservatorium der Universität Teheran
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Zeichnung von Sonnenflecken (Bleistift und Farbstift), erstellt als Projektionsbildzeichnung in Teheran.
Unter Umständen im Zusammenhang mit Beobachtungen des Air Weather Service der U.S. Air Force im Auftrag des NASA Controll Centers in Houston erstellt. Instrument: unbekannt.
Instrument unbekannt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.12.1968, erstellt von M. Rackova-Sebestova am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Cocaine-induced hepatotoxicity
Creators: name: Jordan, Ronald Arlie
Publisher: name: University of Utah
Year: 2012
Subjects: Cocaine - Toxicology
Liver - Glycogenic function
Liver - Necrosis

description: Cocaine treatment caused a dose-related decrease in the microsomal monooxygenase and conjugative activities at one day following administration, with progressive recovery of the activities over five days. Liver pathology showed midzonal necrosis with subsequent hepatocyte regeneration and resolution of necrotic areas. Serum glutamate-pyruvate transaminase activities were dramatically elevated in the early stages of toxicity. Norcocaine, an oxidative metabolite of cocaine, but not benzoyl-ecgonine, a hydrolytic metabolite, produced a pattern of hepa-totoxicity similar to cocaine. Both SKF 525-A and cobaltous chloride pretreatment decreased the hepatotoxic changes caused by cocaine and norcocaine. Phenobarbital pretreatment decreased the depression of monooxygenase activity with no effect on the increase in SGPT activity. Norcocaine-induced liver necrosis shifted from midzonal to periportal areas after phenobarbital-pretreatment of the animals. Pretreatment with 3-methylcholan-threne did not alter the midzonal necrosis caused by cocaine and norcocaine nor did it affect the changes in monooxygenase, conjugative, and SGPT activities. Both cocaine and norcocaine treatment produced a dose-dependent decrease in hepatic glutathione concentration. Diethyl maleate pretreatment potentiated the cocaine- and norcocaine-induced changes in enzyme parameters, while cysteine pretreatment decreased the changes. It was concluded that both cocaine and norcocaine are oxidatively metabolized to a reactive metabolite, and glutathione conjugation may be an important pathway in detoxifying the metabolite.  The possible relationship between cocaine metabolism and cocaine- and norcocaine-induced hepatotoxicity was investigated in rats and mice. The microsomal enzyme systems from both untreated rats and mice were capable of metabolizing cocaine to oxidative and hydrolytic products. The pattern of in vitro me-tabolism of the two species showed quantitative rather than qualitative differences. Benzoylecgonine, a hydrolytic metabolite, was formed in greater amounts in rats than in mice, while norcocaine, an oxidative metabolite, was produced in approximately equal quantities. The total percent of cocaine metabolized was only slightly greater in rats than mice because the latterpro-duced greater quantities of unidentified metabolites. Rats pre-treated with diethyl maleate developed cocaine- and norcocaine-induced hepatotoxicity based on liver pathology and changes in the microsomal monooxygenase, conjugative, and serum glutamate-pyruvate transaminase activities. It was concluded that even though both rats and mice can oxidatively metabolize cocaine and norcocaine to a hepatotoxic reactive intermediate, rats do not normally demonstrate toxicity because of a more favorable ratio of glutathione related detoxication relative to activation.