cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
miR-761-hepcidin/Gpx4 pathway contribute to unexplained liver dysfunction in polycystic ovary syndrome by regulating liver iron overload and ferroptosis
Creators: name: Zheng, Ruoheng
name: Lin, Chuanping
name: Mao, Yuchan
name: Jin, Fan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Aims: To investigate the underling mechanisms of liver dysfunction in patients with polycystic ovary syndrome (PCOS).Materials and methods: PCOS patients were enrolled according to the Amsterdam criteria while PCOS animal model was established by dihydrotestosterone (DHEA) sustained release tablet implantation on its neck. Further liver damage and iron overload were detected by HE and Prussian blue staining. The liver related enzymes, mRNA and protein levels of hepcidin and GPX4 were tested by ELISA, qRT-PCR and Western blot. RNA interference and miR-761 transfection were routinely performed while the regulation of miR-761 on hepcidin and GPX4 was confirmed by luciferase reporter gene analysis.Results: We found that a part of PCOS patients and animal model had unexplained liver damage, which is independent of nonalcoholic fatty liver disease (NAFLD) and accompanied by increased ferrum (Fe) deposition. Besides, the expression of hepcidin and GPX4 that is important effector proteins for ferroptosis was down regulated in liver, showing the importance of iron metabolism in this unexplained liver damage. Based on the miR-761-hepcidin/GPX4 axis, we systematically studied the effects of miR-761 on ferroptosis and Fe deposition, which further influence the phenotype and liver function of PCOS model. From both in vivo and in vitro levels, changes in PCOS disease phenotype and ferroptosis were observed through hierarchical antagonism or overexpression of miR-761, hepcidin and GPX4.Conclusions: our results provide a novel explanation for unexplained liver damage in PCOS and a potential therapeutic target.
Effects of  Punica granatum fruits extract on insulin gene expression and insulin signaling pathway in Alloxan-induced diabetic Wistar rats
Creators: name: Montasser Kouhsari, Shideh
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Objectives: Pancreatic β-cells dysfunction and impairment of hepatic insulin signaling pathways usually conducts to hyperglycemia in diabetes mellitus (DM). Punica granatum (pomegranate) is a traditional plant remedy in Iran due to its positive effects on ameliorating blood glucose homeostasis.
 Methodology: Alloxan monohydrate-diabetic Wistar rats were administrated with pomegranate fruits aqueous extract (PE) and the effects of PE polyphenols on fasting blood glucose (FBG), ins expression, phosphorylation and expression levels of insulin signaling molecules, IR, IRS-1, IRS-2, PI3K and Akt were examined.
 Results: Our data showed a noticeable reduction in FBG by 64.78% in PE treated group. HOMA-IR test showed 57% improvement in PE rats, compared with controls. The results showed an improvement in hepatic expression of irs-1 and akt in PE administrated rats, whereas the damages due to phosphorylation of these proteins were reduced in PE treated group.
 Conclusion: It is suggested that PE consumption may contributes to the modulation of hyperglycemia through betterment of pancreatic β-cells ins expression and hepatic insulin signaling pathways in alloxan-induced diabetic rats.
 Keywords: Alloxan monohydrate, Diabetes mellitus, Hepatic insulin signaling pathways, Insulin resistance, Punica granatum
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 2 (2016): Journal of ISANH Volume 3: Special Issue for Maillard Reaction & Glycation
Caring for Residents with Dementia in Assisted Living Facilities: The Experiences of the Care Staff
Creators: name: Ross, April
Publisher: name: Georgia State University
Year: 2007

description: Within Assisted Living Facilities (ALFs), high staff turnover and the foreseeable future shortage in the workforce population have created a growing urgency to increase the retention of workers in this field. This study examines the experiences of care workers in the dementia care units (DCUs) of ALFs. The specific aims are to learn: 1) what these workers find frustrating and satisfying about their job; and 2) what are the individual-level (e.g., race, education, employment history) and facility-level (e.g., size of unit, workload) factors that affect how they feel about their job. We used qualitative data from interviews with 45 staff and observations gathered in DCUs in five ALFs that varied in size, location, and race of staff.  Findings show that workers' sources of dissatisfaction included heavy workloads, lack of teamwork, and residents' racist remarks and other problem behaviors. Positive relationships with residents were a primary source of satisfaction.
Comparison of telomere length and skin auto fluorescence as markers of ageing in COPD
Creators: name: Reynaert, Niki L
name: Wouters, Emiel FM
name: Rutten, Erica PA
name: Franssen, Frits ME
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Accelerated ageing has been proposed as a pathological mechanism of various chronic diseases, including chronic obstructive pulmonary disease (COPD). This concept has almost exclusively been approached by analyses of individual markers. We investigated if COPD is associated with accelerated ageing comparing telomere length and skin auto fluorescence as markers of the ageing process.
Lung function, leukocyte telomere length, skin auto fluorescence, and markers of systemic inflammation were determined in the ICE-Age study which includes 160 COPD patients, 82 smoking and 38 never smoking controls.
Skin auto fluorescence was higher and telomere length was shorter in the COPD patients compared to both control groups. Significant associations with age, pack years smoked and inflammatory parameters were found for both skin auto fluorescence and telomere length. However, no significant relation between both ageing markers was observed. Furthermore, only telomere length and not skin auto fluorescence was found to be independently associated with lung function.
The present study supports the hypothesis that COPD is a syndrome of accelerated biological ageing. Lung function deterioration in COPD is more closely related to telomere attrition compared to increased skin auto fluorescence.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 2 (2016): Journal of ISANH Volume 3: Special Issue for Maillard Reaction & Glycation
TERRASSE cruise,Alis R/V
Creators: name: SAMADI Sarah
Publisher: name: Sismer
Year: 2008

description: La campagne Terrasse avait trois principaux objectifs : Explorer la diversité de la faune bathyale des monts sous-marins de la ride des Loyautés (CenSeam) et enrichir les collections en échantillons exploitables par les techniques de la biologie moléculaire dans le cadre des programmes internationaux Barcode of Life et Tree of life (plus particulièrement MarBol et Cnidarian Tree of Life) ; Compléter l'échantillonnage pour les projets en cours de génétique des populations sur les gastéropodes et les galathées des monts sous-marins ; Échantillonner des éponges pour un projet sur l'adaptation au milieu profond.Cette campagne visait à établir les échantillonnages qui permettront d'analyser, premièrement l'origine de la diversité de la faune associée aux monts sous-marins, deuxièmement la connectivité entre des populations fragmentées du milieu profond et troisièmement les contraintes évolutives liées à ce milieu. Les échantillonnages ont été comme prévu réalisés à l'aide d'un chalut à perche et d'une drague. Les spécimens ont été fixés en alcool, formol ou congelés selon les traitements prévus à terre. Les projets de rattachement sont CenSeam et Marbol.
TFM01 cruise,Téthys II R/V
Creators: name: TESSON Michel
Publisher: name: Sismer
Year: 2011

description: Etude des systèmes de vallées incisées quaternaires situées sur la plate-forme du Golfe du Lion (programme national CNRS/INSU ACTION MARGES). La campagne TFM 01 avait pour but de compléter la grille de données sismiques acquises par l'équipe depuis 1995. L'objectif spécifique de la campagne était de réaliser des profils pour compléter vers le large l'étude des systèmes de vallées incisées reconnues sur le littoral et la plate-forme interne audois au nord de Cap Leucate. 12 lignes sismiques ont été effectuées totalisant une longueur de 70 miles nautiques.La campagne est rattachée au programme GDR "Action marges" Chantier Méditerranée.
Adding Life to Years: Predicting Subjective Quality of Life among Chinese Oldest-Old
Creators: name: Qin, Huali
Publisher: name: Georgia State University
Year: 2007

description: This study is proposed to examine the relationship between individual and socio-economic factors and subjective quality of life (SQOL) among the Chinese oldest-old. Data was collected from the latest wave of Chinese healthy longevity survey in 2002. The sample of this survey consisted of 11,175 oldest-old who were aged 80 and above at the time of the survey. Kruskal-Wallis test and Mann-Whitney U test were used to examine age, gender, and living arrangements differences in SQOL among Chinese oldest-old. Multiple regression analysis was conducted to understand the influences of individual and socio-economic factors as four groups of predictor variables in SQOL among the oldest-old. The results showed that living with offspring, having children¡¯s frequent visits, living in an institution, participation in activities, higher self-rated health, and higher MMSE scores were positively related to SQOL. Living alone, in rural areas, and having better ADL functions were negatively related to SQOL among Chinese oldest-old. Centenarians and nonagenarians were found to have higher ratings of SQOL than octogenarians. This study may provide insights on how social, cultural, and familial factors influence subjective well-being in the very old age. Study findings may have policy implications for the promotion of quality of life for older adults, specifically, the oldest-old in China.
TEST-OBS cruise,Le Suroît R/V
Creators: name: SINGH Satish
name: CRAWFORD Wayne
Publisher: name: Sismer
Year: 2004

description: L'objectif principal de cette campagne était de déterminer la qualité des OBS INSU récemment acquis. Nous avons déployé plusieurs instruments proches les uns des autres pour une calibration. Pour les calibrations, nous avons utilisé des canons à air de différentes tailles ainsi que des mesures de bruit de fond.
TE_SEA cruise,Côtes De La Manche R/V
Creators: name: MARO Denis
Publisher: name: Sismer
Year: 2000

description: La bande terrestre Côtière de la région de La Hague (Nord Cotentin) est marquée par les radioéléments rejetés en mer et dans l'atmosphère par l'usine de retraitement des combustibles irradiés de la COGEMA, à travers deux types de transferts: - un transfert de radioéléments, émis avec les rejets liquides, du milieu marin vers le milieu terrestre Côtier (embruns),- un transfert direct de radioéléments vers le milieu terrestre Côtier, dû aux retombées locales des rejets (formes gazeuses et aérosols) des cheminées et aux retombées des tirs nucléaires anciens. De nombreuses études traitent du retour vers le continent des radionucléides artificiels rejetés en mer grâce au transport par les aérosols marins. Par contre, le transfert éléments sous formes gazeuses comme le 14C et le 3H a été très peu étudié. L'objectif de cette mission est donc de mettre en évidence les transferts du 14C et du 3H sous formes gazeuses, de la mer vers atmosphère au voisinage du point de rejet en milieu marin de l'usine de retraitement de La Hague.
THALAMACOU cruise,Thalia R/V
Creators: name: Axel, EHRHOLD
Publisher: name: Sismer
Year: 2011

description: Les stocks de laminaires de l'Archipel de Molène ont déjà fait l'objet de plusieurs estimations peu cohérentes entre elles. La profession constate une fluctuation inter-annuelle forte des stocks de Laminaria digitata sur ses lieux de pêche traditionnels et pourrait avoir à envisager une ponction de plus en plus importante sur le stock de Laminaria hyperborea, qui demande cependant des moyens techniques différents. Outre les besoins de la profession, une connaissance de l'état de santé du champ de Molène est aussi un des objectifs du Parc National Marin d'Iroise, qui passe par une combinaison d'outils optiques (lidar), acoustiques (sondeur multifaisceau, sonar interférométrique, écho-sondeur) et d'échantillonnage sur le terrain. Dans ce contexte, l'Agence, via l'expertise de l'IFREMER, souhaite réaliser une carte de distribution du champ d'algues du plateau Molénais et de Ouessant sur la base d'acquisitions nouvelles (optiques, acoustiques, échantillonnages) et une approche de la biomasse. Ceci nécessite de connaître finement la topographie sous-marine de la zone afin de délimiter les substrats préférentiels associées à des vérités de terrain (zone rocheuse), préalables à des travaux de modélisation prédictive des laminaires. Ces nouvelles connaissances contribueront à ce que le PNMI dispose d'un outil de prospective et de pilotage stratégique. Dans ce cadre, les levés réalisés pendant la campagne THALAMACOU ont permis de reconnaître la morphologie et la distribution des types de fond de l'archipel entre 15 et jusqu'à 60 mètres de profondeur. La mission THALAMACOU complète au large, les levés effectués en septembre 2010 sur les zones peu profondes lors de la campagne HALAMACOU (V/O Haliotis).Le projet de rattachement est : Projet 3 : Cartographie opérationnelle des habitats (programme 4).
PHRASEOLOGY IN CONTEMPORARY LINGUISTICS
Creators: name: Xazratqulova, Feruza
Publisher: name: Zenodo
Year: 2024

description: The study of phraseology, which focuses on fixed expressions and idioms, has emerged as a crucial aspect of modern linguistics. This paper delves into the importance of phraseological units within contemporary linguistic research, scrutinizing their semantic and functional characteristics. By investigating various fixed expressions, including idioms, collocations, and proverbs, this research underscores phraseology's role in interpreting language dynamics and cultural subtleties. Additionally, the article addresses recent progress in phraseological studies and their potential impacts on language education and computational linguistics.
Proteomic and bioinformatic analysis of human endometrium from polycystic ovarian syndrome with and without insulin resistance
Creators: name: Yang, Xin
name: Xiaoping, Wang
name: Nan, Ding
name: Jian, Zhang
name: Xiaofeng, Li
name: Liwei, Yuan
name: Zhao, Mengni
name: Wang, Fang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Objective: The aim of this study was to investigate the endometrial proteomic profiles of patients with polycystic ovary syndrome (PCOS) with and without insulin resistance (IR). Method of Study: We collected 40 endometrial samples, including PCOS-IR (n = 21), PCOS-non-IR (n = 12), and control (n = 7). Data-independent acquisition (DIA)-based proteomics method is used to identify the expressed proteins among the three groups. The correlation between pregnancy outcomes and identified proteins was analyzed by Lasso regression. Results: A total of 5331 proteins were identified, while 275 proteins were differentially expressed in the PCOS vs. control group and 215 proteins were differentially expressed in the PCOS-IR vs. PCOS-non-IR group. Platelet degranulation, neutrophil degranulation, and very long-chain fatty acid catabolic processes have been found to play important roles in the endometrium of patients with PCOS-IR. Lasso regression analysis found that ACTR1A, TSC22D2, CKB, ABRAXAS2, and TAGLN2 were associated with miscarriage in patients with PCOS. ACTR1A and CKB were higher in the PCOS-IR group and were positively correlated with HOMA-IR (p < .05). Conclusion: In this study, a panel of proteins was found to be differently expressed in the endometrium. ACTR1A and CKB may be considered as PCOS-IR candidate biomarkers.
Factors Contributing to Job Retention of Direct Care Staff in Urban Assisted Living Facilities
Creators: name: Li, Zhiqing
Publisher: name: Georgia State University
Year: 2007

description: This study examined the influence of personal and workplace factors on direct care workers¡¯ retention in Assisted Living Facilities (ALFs). The sample includes 11 ALFs in urban areas in Atlanta, Georgia and 13 participants from the sample facilities. The findings show that personal and workplace factors interact with each other to influence retention in the long-term care field and retention in a particular facility. The findings of this study may have implications for facility policy and practice to retain workers.
Metabolization of Maillard reaction products by the human colonic microbiota
Creators: name: Hellwig, Michael
name: Bunzel, Diana
name: Huch, Melanie
name: Franz, Charles M.A.P.
name: Kulling, Sabine E.
name: Henle, Thomas
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Objectives: Heat-treatment of foods leads to glycation of individual protein-bound amino acids such as lysine and arginine. Substantial amounts of up to 1000 mg of Amadori compounds (mainly fructoselysine) and up to 75 mg of advanced glycation end products (AGEs, mainly pyrraline and carboxymethyllysine) are ingested with the daily diet [4]. The majority of these products can not pass the intestinal barrier and enter into circulation and could therefore serve as a substrate for bacterial fermentation [2]. Degradation of fructoselysine has already been shown in rat feces cultures [1].
 Methodology: Four MRPs (fructoselysine, carboxymethyllysine, pyrraline, maltosine) were synthesized and anaerobically incubated in the presence of fecal suspensions from 8 human volunteers at 37 °C for up to 72 h. The stability of the compounds was analyzed by HPLC-MS/MS (fructoselysine, CML) or HPLC-UV (pyrraline, maltosine) [3].

 Results: Fructoselysine was degraded nearly completely in the presence of fecal suspensions of all subjects during 4 h, whereas maltosine proved to be completely stable. Pyrraline was degraded by 25-40% in 72 h by the gut microbiota of all subjects. Strong inter-individual differences in the kinetic and extent of degradation appeared when CML was incubated. However, no metabolites (e.g., biogenic amines) could as yet be identified.

 Conclusions: The human large intestinal microbiota is able to degrade individual MRPs. Especially Amadori products such as fructoselysine, which are ingested in comparatively high amounts, can thus possibly have an influence on the composition and viability of the gut microbiota. Further studies will focus on identification of the degrading species and in-depth metabolite analysis.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 2 (2016): Journal of ISANH Volume 3: Special Issue for Maillard Reaction & Glycation
The Relationship of Health Literacy and Locus of Control to Medication Compliance in Older African Americans.
Creators: name: Armstrong, Karen
Publisher: name: Georgia State University
Year: 2007

description: Many older African American adults have inadequate health literacy and are more likely to have chronic illnesses needing medication therapy. African Americans continue to experience significant health disparities in the incidences of cardiovascular disease and diabetes. It was postulated that ethnic disparities in medication compliance are related to a dynamic interplay between low health literacy and health locus of control. Thirty older African Americans taking at least one prescription medication were interviewed. Although the vast majority was well-educated, only 53% displayed adequate health literacy. Most of the participants believed they controlled their health, and over half were noncompliant with their medications. Poor health literacy and health locus of control appeared to influence medication compliance in older African Americans.
The Exercise Attitudes, Perceptions, and Perceived Outcomes of Older Minority Women Participating in a Fall Prevention Program
Creators: name: Hall, Porsha
Publisher: name: Georgia State University
Year: 2008

description: Fall prevention is a serious issue in the health and aging fields, and much attention and research is now being focused on examining why older adults fall and ways to prevent them from falling. Although it has been well-documented that older adults benefit from programs designed to decrease falling by promoting exercise participation, balance training, and fall education; little research has focused on specifically examining how older minority women view preventive exercise programs. This qualitative study explores the experiences of older minority women participating in a fall prevention program. The specific aims of the study are to: 1) gain an understanding of older minority women’s experiences and perceptions about falling and fall prevention; 2) establish what factors influence older minority women to participate in fall prevention programs; and 3) explore participants’ perceived outcomes of program participation. Post-test interviews with 21 participants were analyzed using the method of grounded theory to identify common themes and outcomes associated with participation in a fall prevention program. Findings from this study provide an in-depth look into the factors motivating older minority women to participate in exercise and explore their beliefs regarding falling and fall prevention.
Mutational analysis of minichromosome maintenance complex component (MCM) family genes in Chinese Han women with polycystic ovarian syndrome
Creators: name: Zhou, Jiangyan
name: Liu, Faying
name: Tian, Lifeng
name: Yang, Ming
name: Tan, Jun
name: Liu, Xianxian
name: Li, Peishuang
name: Chen, Jia
name: Chen, Ge
name: Xu, Lixian
name: Peng, Lisha
name: Wu, Qiongfang
name: Zou, Yang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: To investigate whether mutations in the minichromosome maintenance complex component (MCM) family genes were present in patients with polycystic ovary syndrome (PCOS) of Chinese descent. A total of 365 Chinese patients with PCOS and 860 women without PCOS as control who underwent with assisted reproductive technology were enrolled. Genomic DNA was extracted from the peripheral blood of these patients for PCR and Sanger sequencing. The potential damage of these mutations/rare variants was analyzed through evolutionary conservation analysis and bioinformatic programs. Twenty-nine missense or nonsense mutations/rare variants in the MCM genes were identified in 365 patients with PCOS (7.9%, 29/365), all these mutations/rare variants were predicted to be ‘disease causing’ by SIFT and PolyPhen2 programs. Among those, four mutations were reported here for the first time, p.S7C (c.20C > G) in MCM2 (NM_004526.3), p.K350R (c.1049A > G) in MCM5 (NM_006739.3), p.K283N (c.849G > T) in MCM10 (NM_182751.2), and p.S1708F (c.5123C > T) in MCM3AP (NM_003906.4). All of these novel mutations were not found in our 860 control women, or also absent in public databases. In addition, the evolutionary conservation analysis results suggested that these novel mutations caused highly conserved amino acid substitutions among 10 vertebrate species. This study identified a high frequency of potential pathogenic rare variants/mutations in MCM family genes in Chinese women with PCOS, which further expands the genotype spectrum in PCOS.
African American Longevity Advantage: Myth or Reality? A Racial Comparison of Supercentenarian Data
Creators: name: Young, Robert
Publisher: name: Georgia State University
Year: 2008

description: Demographic researchers have identified a crossover pattern between the mortality rates of the Caucasian-American and African-American oldest-old (80+) populations for over a century. Debate has centered on whether the crossover effect is due to age misreporting or the heterogeneity hypothesis or if it continues beyond age 99. This thesis addresses these issues by using new data from the SSA’s study of supercentenarians. The study identified 355 persons aged 110 or older whose ages could be verified, creating the first reliable American dataset for this population group. Analysis of the data has indicated that mortality rates at ages 110-115 were significantly lower for African-American supercentenarians than for their Caucasian-American counterparts, and that the African-American proportion of the population increased steadily with age. The results of this analysis show that the crossover phenomenon is multicausal and cannot be fully accounted for by age misreporting, suggesting a need to consider genetic and environmental impacts on racial variations in maximum human longevity.
Linking Social Support and Sexual Interest among Older Adults in Intimate Romantic Relationships
Creators: name: Griffith, Jennifer
Publisher: name: Georgia State University
Year: 2008

description: This study examines social support and sexual interest among coupled persons aged 57 to 85 in North America. Using quantitative data from the 2006 National, Social Life, Health, and Aging Project (n = 3,005), the dependent variable is sexual interest and the independent variable is social support received from an intimate partner. Using survey and quantitative interview data, I analyze social support older couples receive from their partner, sexual interest, health status, marital status, and gender. In my analysis, I predict that higher levels of social support will positively affect levels of sexual interest, with health, relationship status, and gender mediating the outcomes. This study has gerontological significance because sexuality can impact overall well-being among older adults, and my findings could further our understanding of sexuality among this population.
Oxidative stress markers cannot be used as endometriosis biomarkers in infertile patients
Creators: name: Janša, Vid
name: Osredkar, Joško
name: Verdenik, Ivan
name: Rižner, Tea Lanišnik
name: Frangež, Helena Ban
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Endometriosis is a common benign gynaecological disease that significantly compromises the quality of life of patients. To date, invasive surgery is the method of choice to visually and histologically confirm endometriosis. Thus, there is a major interest to develop noninvasive diagnostic tools. Oxidative stress is one of the proposed mechanisms of pathogenesis and may be involved in pelvic pain, dysmenorrhea, dyspareunia, and infertility in endometriosis patients. Thus, markers of oxidative stress may serve as diagnostic biomarkers for endometriosis. This prospective case–control study assessed erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPX), serum hexanoyl lysine (HEL) and peritoneal fluid HEL. We enrolled 86 women with primary infertility; the case group included 57 women with endometriosis, and the control group included 29 women with unexplained primary infertility. All the patients underwent laparoscopy, and the diagnosis was confirmed histologically. RANDOX and RANSEL reagents were used to determine the levels of SOD and GPX, respectively, and ELISA was used to determine the levels of HEL. We found no statistically significant differences in the erythrocyte levels of GPX (p value 0.623) or SOD (p value 0.122) or the serum or peritoneal fluid levels of HEL (p value 0.562 and 0.329 accordingly). SOD, GPX, and HEL levels most likely do not differ between patients with unexplained infertility and patients with endometriosis.
Optimal number of high-quality cleavage-stage embryos for extended culture to blastocyst-stage for transfer in women 38 years and older
Creators: name: Xue, Xia
name: Li, Wei
name: Li, Mingzhao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: We aimed to evaluate the pregnancy outcomes of cleavage-stage embryo transfers (ETs) for the first time and explore optimal number of high-quality cleavage-stage embryos for extended culture to blastocyst-stage in women of advanced maternal age (AMA). We retrospectively identified 1646 AMA women ≥ age 38 years for the first fresh ETs between January 2014 and December 2020 at our hospital. Double ETs were divided into three groups as follows: DET-HH (two high-quality embryos), DET-HL (one high-quality and one low-quality embryo), and DET-LL (two low-quality embryos) groups. We mainly analyzed the pregnancy outcomes of double cleavage-stage ETs with different embryo grades and blastocyst-stage ETs with different number of high-quality cleavage-stage embryos on day 3. Our data indicated that the DET-HH group had significantly higher clinical pregnancy, ongoing pregnancy, and live birth rates than DET-HL and DET-LL groups (p < .05). For extended culture to blastocyst-stage with 2 (D3-2H), 3 (D3-3H), and 4 (D3-≥4H) high-quality cleavage-stage embryos, the D3-≥ 4H group had significantly higher ongoing pregnancy and live birth rates than D3-2H and D3-3H groups (p < .05). We observed that the number of high-quality embryos on day 3 was independently associated with live birth rate for blastocyst transfers (OR: 1.133, 95% CI 1.023–1.256, p = .017). There were no significant differences in the clinical pregnancy, ongoing pregnancy and live birth rates among DET-HH, D3-2H and D3-3H groups (p > .05). Extended culture to blastocyst-stage for transfer was safe and recommended for AMA women with ≥ 4 high-quality embryos on day 3.
Client and Caregiver Perceptions of Adult Day Services:  A Program Evaluation
Creators: name: O'Donnell, Dianne
Publisher: name: Georgia State University
Year: 2008

description: The MJCCA Weinstein Center for Adult Days Services provides social activities and medical services to older adults, including individuals with memory loss. Center administrators requested a program evaluation to explore attraction and retention of clients, beneficial effects of Center activities, and the current case management program. Regular members of the Center’s Traditional Group (n=14) and family caregivers of Memory Loss program attendees (n=10) participated in open-ended interviews in focus groups. Content analysis revealed that clients consider Center activities, staff, and social environment superior to the few other day care alternatives. The activities benefit clients primarily physically and emotionally. Potential areas of improvement include enhanced communication with caregivers and more engaging, mentally-stimulating activities personally significant to participants. Findings reveal that person-centered care is appropriate in the adult day service setting and may guide the Center in program modifications. The evaluation partially satisfies new rules in Georgia for licensure and quality assurance.
Medication Management and Regulation in Assisted Living Facilities in the State of Georgia
Creators: name: Luo, Shanzhen
Publisher: name: Georgia State University
Year: 2009

description: Medication management is among the most commonly cited reasons for moving to assisted living and is closely associated with resident quality of life. Yet, the issue has received little research attention. Using data from the state-wide study, “Job Satisfaction and Retention of Direct Care Staff in Assisted Living”, this thesis examines medication management practices and accompanying regulations across 45 facilities in Georgia. A combination of quantitative and qualitative analyses is used to examine surveys with 370 direct care workers (DCWs) and in-depth, qualitative interviews with 41 DCWs and 44 administrators. Findings suggest that medication practices are not uniform and vary across settings and frequently, within facilities, in some cases violating regulations. Facility size, administrative philosophy, staff training and backgrounds, resident frailty, communication between staff, and ambiguous regulations, influence medication management. Future improvement will depend on clarifying and modifying existing regulations in ways that are achievable in practice and protect residents’ rights.
Age Differences in Substance Use and Social Support among Recently Incarcerated Adult Females
Creators: name: Young, Tiffany
Publisher: name: Georgia State University
Year: 2009

description: While men retain the highest rates of incarcerations, the female prison population has tripled in the last decade (Covington, 2007; Henderson, 1998). The goal of this study was to examine micro-level forces, such as social support, substance use, and childhood trauma, in a sample of 188 recently incarcerated women, aged 18-58. Using an ANOVA with ages grouped 18-29, 30-39, and 40-58, age differences in substance use were identified, with the 30-39 year old group reporting more alcohol and drug use than the 18-29 year old group. There were no age differences on social support or childhood trauma. Multiple regression analyses revealed that older age and less social support predicted more alcohol use and older age alone predicted drug use. These results illustrate a need for deeper exploration of these micro forces across the life course of incarcerated women and the need for age-specific programs with at-risk populations to address different use patterns.
THALASSA 7A cruise,Thalassa R/V
Creators: name: CABIOCH Louis
Publisher: name: Sismer
Year: 1983

description: Dynamique hydro-sédimentaire : dynamique des particules en suspension en relation avec les courants de marée en Baie de Seine orientale. Flux entrants et sortants, transports horizontaux et taux de sédimentation. Propriété et origine du matériel en suspension. Hydrologie-Géochimie : traceurs des influences estuariennes et marines. Cycle géochimique du fer, distribution des différentes formes, état de valence, rôle de la matière organique dans sa floculation, effets d'entrainement sur Cu, Pb, Cd et pouvoir complexant des différentes eaux vis-à-vis de ces métaux.
Developmentally Disabled Older Adults in Georgia: Rural, Metropolitan, and Urban Long Term Housing Availability
Creators: name: Cermak, Tracy
Publisher: name: Georgia State University
Year: 2009

description: Older adults with developmental disabilities often experience similar age-related health changes as their typically developing peers. However, they also face challenges associated with aging with a life-long disability. Because of the changes in life expectancy for people with developmental disabilities, there is a growing need for long-term residential care. The current study examines a sample of 90 counties in the state of Georgia. In addition to descriptive analysis, regression analysis was used to examine bed availability with county type (urban, rural, and metropolitan), age, race, income, education, and disability status as potential predictors.  Preliminary analyses revealed that rural counties, on the whole, had more beds available than urban or metropolitan counties.  However, these results were partially mediated by the following within county variables: adult disability status, income, older age, and racial makeup of the county.
THALASSA 7B cruise,Thalassa R/V
Creators: name: CABIOCH Louis
Publisher: name: Sismer
Year: 1983

description: Projet GRECO MANCHE : Cartographie sédimentaire du plateau continental : biogéographie, écologie sédimentaire. Acquisition des bases pour la connaissance des interactions à distance entre peuplements du plateau continental et des relations espèces exploitées/peuplements benthiques.
Serum uric acid and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
Creators: name: Su, Shaofei
name: Zhang, Enjie
name: Gao, Shen
name: Zhang, Yue
name: Liu, Jianhui
name: Xie, Shuanghua
name: Yue, Wentao
name: Liu, Ruixia
name: Yin, Chenghong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Cell Biology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Serum uric acid (SUA) is considered as a risk factor for gestational diabetes mellitus (GDM). However, current studies showed inconsistent results. This study aimed to explore the relationship between SUA levels and GDM risk. Eligible studies were retrieved from PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang databases up to November 1, 2022. The pooled standardized mean difference (SMD) and 95% confidence interval (CI) were used to represent the difference in SUA levels between GDM women and controls. The combined odds ratios (OR) and 95% CI were applied to assess association between SUA levels and GDM risk. Subgroup analyses were conducted on study continents, design, and quality, detection time of SUA, and GDM diagnostic criteria. Totally 11 studies including five case-control and six cohort studies, in which 80,387 pregnant women with 9815 GDM were included. The overall meta-analysis showed that the mean SUA level in GDM group was significantly higher than in controls (SMD = 0.423, 95%CI = 0.019–0.826, p = .040, I2 = 93%). Notably, pregnant women with elevated levels of SUA had a significantly increased risk of GDM (OR = 1.670, 95%CI = 1.184–2.356, p = .0035, I2 = 95%). Furthermore, subgroup analysis performed on the detection time of SUA showed a significant difference in the association between SUA and GDM risk within different trimesters (1st trimester: OR = 3.978, 95%CI = 2.177–7.268; 1st to 2nd trimester: OR = 1.340, 95%CI = 1.078–1.667; p between subgroups <.01). Elevated SUA was positively associated with GDM risk, particularly in the 1st trimester of pregnancy. Further studies with high quality are required to validate the findings of this study.
Oedaleus senegalensis
Creators: name: Felix, Rob
name: Bouwman, Jaap
name: Odé, Baudewijn
name: Ketelaar, Robert
name: Pham, Duc Minh
name: Bailey, James
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Oedaleus
Oedaleus senegalensis

description: Oedaleus senegalensis (Krauss, 1877)
Figs 69, 70, 71
References for Socotra.
Burr 1903: 412, 418; Popov (in Uvarov and Popov (1957)): 378; Ritchie 1981: 87, fig. 160; Wranik 2003: 324, plate 156.
Diagnostic notes.
Oedaleus senegalensis is a primarily greenish or light brown, sizeable Oedipodine grasshopper with long wings (Figs 69, 70). The pronotum is tectiform, slightly saddle-shaped, with light markings forming an open X. The basal two-fifths of the tegmina are dark brown, transversed with a clear pale band. The distal half is primarily clear with darker cells and blackish veins. The basal half of the hind wing is yellowish, at the tip hyaline, with a narrow black fascia, forming a (nearly) complete band, not reaching the posterior margin of the wing.
Ritchie (1981) revised the genus Oedaleus Fieber, 1853 and identified the taxon present on Socotra as Oedaleus senegalensis.
Distribution and occurrence.
The species occurs from the Canary Islands and West Africa through Sub-Saharan Africa to Arabia, western Russia and south-western India. On Socotra, it is known to occur on several sites scattered over the island (Fig. 71).
Habitat and biology.
O. senegalensis is, like other members of the genus, a geophilous and graminivorous species occurring on dry savannah grasslands (Hemp and Rowell 2020). On Socotra, it has been found in short, grassy vegetation and on bare ground on the coastal plain (Popov in Uvarov and Popov (1957)). Records are from the lower parts of the island from 10–500 m a. s. l. in sparse dwarf shrubland and low Croton - Jatropha shrubland. In 2009 and 2010, we found the species at only two sites: at Qeysoh and in the low hills where Wadi Dineghen flows into Hadiboh Plain. Both sites are characterised by bare ground alternated with sparse and low vegetation. Records are from all seasons.
Bioacoustics.
The related Oedaleus decorus (Germar, 1825) emits quiet, rattling sounds during flight. During rivalry, buzzing sounds are emitted. Courtship consists of 0.5–1.1s sounds, emitted with irregular intervals (Roesti and Keist 2009). On Socotra, sounds emitted by O. senegalensis have not been recorded.
description: Published as part of Felix, Rob, Bouwman, Jaap, Odé, Baudewijn, Ketelaar, Robert, Pham, Duc Minh & Bailey, James, 2025, The grasshoppers and crickets (Orthoptera) of the Socotra Archipelago (Yemen): a comprehensive overview and a description of a new Oecanthus Tree Cricket (Oecanthidae), pp. 21-166 in Contributions to Entomology 75 (1) on pages 21-166, DOI: 10.3897/contrib.entomol.75.e144389
Administrators in Assisted Living: Who They Are and What They Do
Creators: name: Glover, Ailie
Publisher: name: Georgia State University
Year: 2009

description: The assisted living industry is predicted to experience considerable growth due to the simultaneous aging of the baby boom generation and their subsequent need for long-term care. This study investigates individuals’ pathways to administration in assisted living and the ways in which assisted living administrators define and carry out their roles. The study contributes to the understanding of the knowledge, skills, and personal traits needed by those who assume these vital leadership roles in an industry poised to care for the bourgeoning population of older adults. The sample for this study is 44 administrators who work in a random sample of 45 assisted living facilities in Georgia. Qualitative methods were used to analyze the data. The data revealed that multiple multi-level factors not only facilitate an administrator’s pathway to AL administration, but these factors also help to shape how an administrator experiences his or her role within an ALF.
ACRYLAMIDE, A DIETARY GLYCATED PRODUCT IMPLICATED IN INTESTINAL INFLAMMATION
Creators: name: Vignal, Cécile
name: Djouina, Madjid
name: Grossin, Nicolas
name: Desreumaux, Pierre
name: Boulanger, Eric
name: Body-Malapel, Mathilde
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Cécile Vignal, Nicolas Grossin, Madjid Djouina, Pierre Desreumaux, Eric Boulanger, Mathilde Body-Malapel
 Objectives: A strong body of evidence supports an environmental influence in the development of Inflammatory Bowel Diseases (IBD). Our aim was to determine the effects of acrylamide on intestinal homeostasis. Methods: C57bl6 mice received increasing doses of acrylamide in their drinking water (25; 50 and 100μg/kg/day) for 9 months. Colon was harvested and assessed for macroscopic, structural and histological modifications. Markers of intestinal barrier, inflammatory and immune responses were quantified. Results: The 3 doses of acrylamide induced structural abnormalities of the colon with a modification of intestinal permeability. Crypts depth, number of goblet cells per crypt and Muc 2 expression were higher in mice receiving acrylamide. Acrylamide induced a significant increase of myeloperoxidase activity and oxidative stress response compared to control mice. The immune response was also disturbed; with an increased expression of Th1 (TNF, IFNg) and Th2 cytokines (IL-4) and a decreased expression of Th17 cytokines (IL17f) in mice receiving acrylamide. Conclusion: Acrylamide disturbed intestinal homeostasis with architectural modifications, altered permeability, increased inflammation and mucosal immune response. More studies are now needed to evaluate the role of acrylamide in IBD.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 2 (2016): Journal of ISANH Volume 3: Special Issue for Maillard Reaction & Glycation
Metabolic characteristics of obese patients with polycystic ovarian syndrome: a meta-analysis
Creators: name: Pan, Xiaotian
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Though recent studies have pointed out different manifestations between obese and nonobese patients with polycystic ovarian syndrome (PCOS), there is no clear evidence to confirm this viewpoint. Therefore, the metabolic characteristics of obese and nonobese patients with PCOS were systematically compared through meta-analysis in this study. Data were searched from PubMed, Web of Science, Embase, Cochrane Library, CNKI, and Wanfang databases. Articles on obese and nonobese patients with PCOS published from database inception to January 2022 were included. Meta-analysis was performed using Stata 16.0 statistical software. A total of 739 articles were initially retrieved, and ultimately 14 studies were involved in the meta-analysis. Specifically, there were 801 patients in the observation group (obese patients with PCOS) and 925 patients in the control group (nonobese patients with PCOS). Compared with the control group, the observation group had significantly lower levels of sex hormone-binding globulin (SHBG), high-density lipoprotein (HDL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and higher levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL). Nevertheless, there were no significant differences between the two groups in systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, and testosterone. Compared with nonobese patients with PCOS, obese patients with PCOS have worse blood lipid parameters and lower levels of LH and FSH. Also, there are significant differences in metabolic characteristics between the two groups of patients. Most importantly, our findings provide guidance for the clinical diagnosis and treatment of PCOS.
Lonliness of Older Adults in Rural China
Creators: name: Guo, Zhen
Publisher: name: Georgia State University
Year: 2009

description: This study examined factors that influenced loneliness among rural elders in China. Data were
collected from the latest wave of Living and Employment of Population Survey in 2005 (provided by Renmin University, China). The sample of this survey consisted of 284 rural elders in China. T?tests was used to examine the influence of gender, marital status, health, financial support, and living arrangements
differences in loneliness perception among Chinese rural elders. Multiple regression analysis was conducted to understand the influences of age and socio?economic status on loneliness among the rural elders. This study provided insights for a better understanding of individual, social, and familial factors that influenced subjective loneliness in later life. Findings from this study might contribute to policymaking
decisions regarding improvements of psychological well?being among older adults in China.