cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Creators: name: Cherfils, Jacqueline
name: Rossman, Kent L.
name: Vigil, Dominico
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: There is now considerable and increasing evidence for a causal role of aberrant activity of the Ras superfamily of small GTPases in human cancers. These GTPases act as GDP-GTP-regulated binary switches that control many fundamental cellular processes. A common mechanism of GTPase deregulation in cancer is the deregulated expression and/or activity of their regulatory proteins, guanine nucleotide exchange factors (GEFs) that promote formation of the active GTP-bound state and GTPase activating proteins (GAPs) that return the GTPase to its GDP-bound inactive state. We assess the association of GEFs and GAPs with cancer and their druggability for cancer therapeutics.
Letter from David McDonald, Rehabilitation of Building 902, Randolph Air Force Base, Texas
Creators: name: McDonald, David A.
Publisher: name: Department of the Air Force, Randolph Air Force Base
Year: 1991
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Building 902
valueUri: https://core.tdar.org/browse/other-keyword/146467/building-902
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Randolph Air Force Base has written to the Texas Historical Commission in support of their recommendations concerning the rehabilitation of Building 902 and the completion of Section 106 process. This letter is part of a group of correspondence concerning a federal undertaking at Building 902, Randolph Air Force Base, Texas. The project includes modification, refurbishment and replacement of windows and doors.
Memorandum of Agreement Between Fort Sam Houston and the Texas State Historic Preservation Officer Regarding the Demolition of Properties Eligible for the National Register of Historic Places, Demolition of Building 5101 and 5002, Fort Sam Houston, Texas
Creators: name: Fort Sam Houston
Publisher: name: Fort Sam Houston
Year: 2000
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Building 5002
valueUri: https://core.tdar.org/browse/other-keyword/146654/building-5002
subject: Building 5101
valueUri: https://core.tdar.org/browse/other-keyword/146667/building-5101
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An unsigned agreement regarding the Department of the Army, Fort Sam Houston and Advisory Council on Historic Preservation, to demolish buildings 5101 and 5002. Fort Sam Houston has determined that the Demolition of Buildings 5101 and 5002 at Camp Bullis will have an adverse effect on these properties, which are eligible for the National Register of Historic Places, and has consulted with the Texas State Historic Preservation Officer pursuant to 36 CFR Part 800, regulations implementing Section 106 of the National Historic Preservation Act (16 U.S.C. Section 470f).
Impact of the Quick-Response Code Based In-Class Assignments on Students Engagement and Retention
Creators: name: Goulding, Richard R. J.
name: Harlick, Anna Maria
name: Kelly, Richard
name: Oksanen, Karoliina
Publisher: name: Papers on Postsecondary Learning and Teaching
Year: 2017

description: Papers on Postsecondary Learning and Teaching, Vol. 2 (2017)
A Narrative Inquiry into the Experiences of Accessing and Participating in Healthcare of Syrian Women who Arrived in Canada as Refugees
Creators: Malloy, Alix, H
Publisher: name: University of Alberta Library
Year: 2022

Gaps in healthcare exist for newcomers, with many experiencing poor quality healthcare compared to the general population. Immigrant and refugee women are particularly disadvantaged and often experience unmet health needs. Despite this, there is a lack of research inquiring into the experiences of refugee women when accessing and participating in healthcare in their host country. I conducted a narrative inquiry study into the experiences of two Syrian refugee women of childbearing age when accessing and participating in healthcare in their host country. Narrative inquiry is a way to inquire into experiences as stories lived and told. By attending to these stories, I gained a better understanding of the complexities surrounding their experiences of healthcare in Canada. By engaging in telling and retelling these stories across time, place and social contexts various narrative threads emerged. The threads that resonated across the experiences of both participants included intentionality and good care, as well as agency and action.
A prospective comparison of bipolar I and II subjects with and without comorbid cannabis use disorders from the COGA dataset
Creators: name: Preuß, Ulrich
name: Hesselbrock, Michie N.
name: Hesselbrock, Victor M.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Objective: The comorbidity of alcohol and substance use disorders among persons with bipolar disorder is elevated, as indicated by epidemiological and clinical studies. Following alcohol use, cannabis is the most frequently used and abused illicit substance among bipolar individuals, and such use may lead to comorbid cannabis use disorders (CUD). Previous research indicated that CUDs were related to a more severe course of bipolar disorder and higher rates of other comorbid alcohol and substance use disorders. Few studies, however, have conducted longitudinal research on this comorbidity. The aim of this study is to investigate the influence of CUD on the course of bipolar I and II individuals during a 5-year follow-up. Methods: The characteristics of bipolar disorder, cannabis use disorders, and other alcohol and substance use disorders, as well as comorbid mental disorders, were assessed using a standardized semi-structured interview (SSAGA) at both baseline and the 5-year follow-up. N = 180 bipolar I and II patients were subdivided into groups of with and without comorbid cannabis use disorders (CUD). Results: Of the 77 bipolar I and 103 bipolar II patients, n = 65 (36.1%) had a comorbid diagnosis of any CUD (DSM-IV cannabis abuse or dependence). Comorbid bipolar patients with CUD had higher rates of other substance use disorders and posttraumatic stress disorders, more affective symptoms, and less psychosocial functioning at baseline and at 5-year follow-up. In contrast to previously reported findings, higher rates of anxiety disorders and bipolar disorder complications (e.g., mixed episodes, rapid cycling, and manic or hypomanic episodes) were not found. The effect of CUD on other substance use disorders was confirmed using moderation analyses. Conclusions: A 5-year prospective evaluation of bipolar patients with and without CUD confirmed previous investigations, suggesting that the risk of other substance use disorders is significantly increased in comorbid individuals. CUD has a moderation effect, while no effect was found for other mental disorders. Findings from this study and previous research may be due to the examination of different phenotypes (Cannabis use vs. CUD) and sample variation (family study vs. clinical and epidemiological populations).
Seismology and modeling of the bright, wide eclipsing binary γ Persei
Creators: name: Molnár, László
name: Ádám, Rozália
name: Kalup, Csilla
name: Grundahl, Frank
Publisher: name: Zenodo
Year: 2024

description: γ Persei is a naked-eye, very wide binary system, in which eclipses occur every 14.6 years. Unlike the 1990 and 2019 eclipses, the 2005 eclipse was not observed due to the star's proximity to the Sun. However, we were able to extract the eclipse from the space-based SMEI observations. More recently, TESS observed the star in two of its sectors and, by pure coincidence, one of those included the 2019 eclipse of the system. Although the primary star is a large red giant, which makes its oscillation frequencies very low, we were able to estimate its 𝜈_max. From that, we estimate the mass of the primary to be about 2.5 M⊙, based on scaling relations. Previous estimates of the primary's mass varied between 2.5 and 3.5 M⊙, and physical parameters suggested the possibility of the components being not coeval, i.e., that one of them was a merger product. We then modeled the system with the PHOEBE code, fitting historical radial-velocity measurements and multicolor and TESS photometry of the eclipses. With the help of this model, we also detected a secondary eclipse, for the first time, in the SMEI light curve.
Electrothermal Actuation of NEMS Resonators: Modeling and Experimental Validation
Creators: name: Ma, Monan
name: Ekinci, Kamil L.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the electrothermal actuation of nanomechanical motion using a combination of numerical simulations and analytical solutions. The nanoelectrothermal actuator structure is a u-shaped gold nanoresistor that is patterned on the anchor of a doubly-clamped nanomechanical beam or a microcantilever resonator. This design has been used in recent experiments successfully. In our finite-element analysis (FEA) based model, our input is an ac current; we first calculate the temperature oscillations due to Joule heating using Ohm's Law and the heat equation; we then determine the thermally induced bending moment and the displacement profile of the beam by coupling the temperature field to Euler-Bernoulli beam theory with tension. Our model efficiently combines transient and frequency-domain analyses: we compute the temperature field using a transient approach and then impose this temperature field as a harmonic perturbation for determining the mechanical response in the frequency domain. This unique modeling method offers lower computational complexity and improved accuracy, and is faster than a fully transient FEA approach. Our dynamical model computes the temperature and displacement fields in time domain over a broad range of actuation frequencies and amplitudes. We validate the numerical results by directly comparing them with experimentally measured displacement amplitudes of NEMS beams around their eigenmodes in vacuum. Our model predicts a thermal time constant of 1.9 ns in vacuum for our particular structures, indicating that electrothermal actuation is efficient up to ~80 MHz. We also investigate the thermal response of the actuator when immersed in a variety of fluids.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: L’intervista a Elena Bucci ripercorre gli itinerari dusiani e le tappe creative che hanno accompagnato la scrittura scenica di Non sentire il male, spettacolo del 2000 dedicato a Eleonora Duse, di cui Bucci è autrice, attrice e regista. L’indissolubile intreccio di vita professionale, artistica e privata della Grande Attrice italiana viene qui affrontato attraverso una personale tessitura di documenti e fatti storici, che Bucci passa nel filtro di un esplicito riconoscimento autobiografico: dalla sua formazione artistica alla fondazione della compagnia Le belle bandiere passando per il Teatro di Leo, tappe in cui la figura “madrina” di Duse è sempre evocata. Nel corso dell’intervista si ricostruiscono inoltre i momenti salienti di ideazione e sviluppo dello spettacolo, non solo in relazione alla drammaturgia ma anche rispetto all’allestimento e alle sue differenti versioni (site-specific, per la sala teatrale, in forma di concerto). Accompagnano l’intervista alcuni apparati di contesto.
description: The interview with Elena Bucci retraces dusian itineraries and the creative phases that traced the scenic writing of Non sentire il male (2000), performance dedicated to Eleonora Duse, whose Bucci is the author, actress and director. The indissoluble connection of the professional, artistic and private life of the Great Italian Actress is processed here through a personal weaving of documents and historical facts, which Bucci passes through the filter of an explicit autobiographical transfer: from her artistic training to the foundation of the company Le belle bandiere through the Teatro di Leo, moments in which the figure of Duse is always invoked like a “godmother”. During the interview, the salient passages of the conception and development of the performance are also reconstructed, not only in relation to the dramaturgy but also with respect to the staging and its different versions (site-specific, for black box, like a live concert). Some contextual notes support the interview.
Exploring Parental and Instructor Perspectives of Learning in the Natural Environment for Young Children: A Qualitative Study
Creators: Molner, Brittany
Publisher: name: University of Alberta Library
Year: 2022

Background: Nature-based or outdoor experiences have important implications for childhood learning and development. Nature-based learning (NBL) utilizes the benefits of nature by weaving the goals of the school curriculum into the natural environment (Larimore, 2016). A paucity in the NBL literature is evident, although research has steadily grown with the increase in programming following the onset of the COVID-19 pandemic. To expand our current knowledge, I explored the following questions: (RQ1) how do parents and instructors perceive children’s learning in the natural environment in an early childhood learning setting? and (RQ2) how is remote learning during the COVID-19 pandemic experienced by parents with young children registered in NBL? Departing from the current research available, my study utilized a health promotion lens to critically examine NBL programs.

Methods: This qualitative study followed an Interpretive Description (ID) methodology (Thorne et al., 1997). I purposefully recruited 10 parents and 3 NBL instructors to share their experiences via phone or virtual interview. Instructor interviews were included to provide insight on the experience of learning and inform parent interviews. Data analysis was conducted using thematic analysis (Braun & Clarke, 2006) supported by constant comparison strategies (Glaser & Strauss, 1967).

Results: Findings were grouped by research question. Findings that explored the experiences of young children in nature were organized into four themes: (1) Nature-Based Education: A Foundation for Learning; (2) Natural Spaces for Health and Mental Health Development; (3) Community Building; and (4) Capacity Building. Findings that shed light on the remote learning experiences from the perspectives of parents were organized into four other themes: (1) Balancing Responsibilities; (2) Gender Inequities Amplified by the COVID-19 Pandemic; (3) Nature for Health Promotion; and (4) Connection.

Conclusion: Based on the findings of this study, NBL programs can be positioned as a health promotion intervention for the benefit of child, family, and community health and wellbeing. The use of NBL as a health promotion intervention may have greater implications for families with limited outdoor experience and in future crises planning.
Response from Stan Graves to Richard Strimel, Housing Area 3 Improvements, Fort Sam Houston, Texas
Creators: name: Graves, Stanley O.
name: Kinsey, Teresa
Publisher: name: Texas Historical Commission
Year: 1992
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Housing Area 3
valueUri: https://core.tdar.org/browse/other-keyword/156768/housing-area-3
subject: Artillery Post
valueUri: https://core.tdar.org/browse/other-keyword/156806/artillery-post
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Fort Sam Houston submitted to the Texas Historical Commission a 90% design phase drawings for modifications to housing in Artillery Post. The project scope has been reduced to cover HVAC, kitchen, bathroom, and storage remodeling. The Commission concurs with Fort Sam Houston’s determination of No Adverse Effect for this project. Carbon copied to this letter is Michael Hilger.
title: Was ich anhatte – Schuld ist nicht das Opfer
Creators: name: Woersdoerfer, Pauline
Publisher: name: DuEPublico
Year: 2022
Subjects: subject: Körper
subject: Gesellschaft
subject: Beziehungen
subject: 300

description: In der Diskussion um sexualisierte Gewalt rückt häufig die Kleidung in den Vordergrund und sucht damit die Schuld beim Opfer. Die Wanderausstellung Was ich anhatte möchte mit dieser Verantwortungsübertragung an die Opfer brechen. Die Ausstellung bewegt, wühlt auf und gibt zu Denken.
description: blog interdisziplinäre geschlechterforschung
Correspondence Packet, 1992 Installation of New Fire Doors Building 201, Randolph Air Force Base, Texas
Creators: name: Walter, Chelsea
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Fire Door
valueUri: https://core.tdar.org/browse/other-keyword/158927/fire-door
subject: Building 201
valueUri: https://core.tdar.org/browse/other-keyword/158250/building-201
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A set of letters concerning the installation of a new fire door in Building 201, Randolph Air Force Base, Texas. Attachments to the correspondence include the building floor plan, photographs, conversion chart, and fire door data.
OAHP Inventory, Building 2186 Veterinary Hospital and Stable, Fort Sam Houston, Texas
Creators: name: Walter, Chelsea
Publisher: name: Office of Archaeology and Historic Preservation
Year: 1978
Subjects: subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/83681/fort-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Veterinary Hospital
valueUri: https://core.tdar.org/browse/other-keyword/159075/veterinary-hospital
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Stable
valueUri: https://core.tdar.org/browse/other-keyword/41907/stable
subject: Building 2186
valueUri: https://core.tdar.org/browse/other-keyword/146535/building-2186
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An inventory form by the Office of Archaeology and Historic Preservation for Building 2186 at Fort Sam Houston, Texas. The structure was built in 1908 as a veterinary hospital and stable.
Counterfactual Reasoning in Observational Studies
Creators: Hassanpour, Negar
Publisher: name: University of Alberta Library
Year: 2022

As one of the main tasks in studying causality, the goal of Causal Inference is to determine "whether" (and perhaps "how much") the value of a certain variable (i.e., the effect) would change, had another specified variable (i.e., the cause) changed its value. A prominent example is the counterfactual question "Would this patient have lived longer had she received an alternative treatment?".

The first challenge with causal inference is the unobservability of the counterfactual outcomes 一 i.e., outcomes obtained by applying the treatments that were not administered. The second common challenge is that the training data is often an observational study that exhibits selection bias 一 i.e., the treatment assignment can depend on the subjects' attributes.

In this dissertation, I have explored ways to address the above-mentioned challenges. Specifically, my Research Contributions (RCs) are the following:

My first RC addresses the first challenge:

RC1. Unobservable counterfactuals prohibit proper evaluation of different methods' performance in estimating treatment effects. We provide an algorithm that can synthesize realistic observational datasets that exhibit various degrees of selection bias, then demonstrate that it can effectively assess various contextual bandit methods in the literature.

The remaining RCs are related to the second challenge:

RC2. Learning a common representation space that makes the transformed dataset close to a Randomized Controlled Trial (RCT), is a good strategy to reduce selection bias. We devise a method that further alleviates selection bias (attempting to account for it) by incorporating appropriate re-weighting schemes and show that it outperforms its competitors in the literature.

RC3. Without loss of generality, we assume that three non-noise underlying factors generate any observational data. We devise a method that explicitly models these sources and argue that such model can better deal with selection bias. We then demonstrate its superior performance compared to the competing causal inference methods in the literature.

RC4. The majority of current causal effect estimation methods fall under the category of discriminative approaches. A promising direction is to consider developing generative models, in an attempt to shed light on the true underlying data generating mechanism, which in turn is useful for the downstream task of counterfactual regression. We develop such a method and show empirically that it significantly outperforms state-of-the-art.
Synthesis of new organoselenium-based succinanilic and maleanilic derivatives and in silico studies as possible SARS-CoV-2 main protease inhibitors
Creators: name: Shaaban, Saad
name: Al-Faiyz, Yasair S.
name: Alsulaim, Ghayah M.
name: Alaasar, Mohamed
name: Amri, Nasser
name: Ba-Ghazal, Hussein
name: Al-Karmalawy, Ahmed A.
name: Abdou, Aly
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Herein we report the synthesis of organic selenide-based maleanilic and succinanilic acids in good yields (up to 95%). Their structural identities were elucidated by spectroscopic techniques (e.g., IR, 1H- & 13C-NMR, and MS). The ADMET analysis, molecule electrostatic potential map, DFT, and frontier molecular orbital were used to study the organoselenium compounds’ pharmacokinetics, drug-likeness characteristics, geometries, and chemical and electronic properties. Moreover, a molecular docking tool was employed to investigate the organic selenides’ ability to inhibit the SARS-CoV-2 Mpro target (PDB: 7BFB). Within this context, organic selenides exhibited promising binding affinities to the SARS-CoV-2 Mpro receptor in the following order (12 > 11 > 10 > 9 > 7 > 8). Furthermore, molecular dynamics simulations were also carried out for 200 ns to evaluate the exact behavior of the most active compound (12) within the Mpro binding pocket of SARS-CoV-2 compared with its co-crystallized inhibitor (Co).
An Ising Machine based on an Improved Parallel Annealing Algorithm for Solving Traveling Salesman Problems
Creators: Tao, Qichao
Publisher: name: University of Alberta Library
Year: 2022

Annealing-based Ising machines have shown promising results in solving combinatorial optimization problems. As a typical class of these problems, however, traveling salesman problems (TSPs) are very challenging to solve due to the constraints imposed on the solution. This thesis proposes a parallel annealing algorithm for a fully connected Ising machine that significantly improves the accuracy and performance in solving constrained combinatorial optimization problems such as the TSP. Unlike previous parallel annealing algorithms, this improved parallel annealing (IPA) algorithm efficiently solves TSPs using an exponential temperature function with a dynamic offset. Compared with digital annealing (DA) and momentum annealing (MA), the IPA reduces the run time by 44.4 times and 19.9 times for a 14-city TSP, respectively. Larger scale TSPs can be more efficiently solved by taking a k-medoids clustering approach that decreases the average travel distance of a 22-city TSP by 51.8% compared with DA and by 42.0% compared with MA. This approach groups neighboring cities into clusters to form a reduced TSP, which is then solved in a hierarchical manner by using the IPA algorithm on each cluster.

Furthermore, an Ising machine that implements this annealing algorithm is designed by using a half-precision floating-point representation of the coefficients in the Ising model. This design reuses adders in the local field accumulator units (LAUs) for variable calculation and approximates the momentum scaling factor by a linear increment to save hardware. Approximate arithmetic is considered in the design for improving the speed of accumulation in the LAUs. A hybrid approximation method using lower-part-OR truncated adders (LOTAs) is applied and shown to reduce the delay of the circuit by 3.8% at the cost of an increase in average travel distance

by 1.9%. Finally, an IPA-based Ising machine prototype with 64 spins is built and synthesized by using the Synopsys Design Compiler. Using a 28-nm CMOS process with a supply voltage of 1.0 V, a temperature of 25 ◦C, and a clock frequency of 200 MHz, the total area of the circuit is 6.262 mm2, the power dissipation is 41.108 mW, and the delay is 3.82 ns. Compared with other designs, the area and power dissipation of this circuit are larger due to the implementation of a half-precision floating-point representation. However, the IPA-based Ising machine is expected to solve more complicated problems and improve the solution quality.
Vehicle Detection and Tracking Techniques: A Concise Review
Creators: name: Hadi, Raad Ahmed
name: Sulong, Ghazali
name: George, Loay Edwar
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Vehicle detection and tracking applications play an important role for civilian and military applications such as in highway traffic surveillance control, management and urban traffic planning. Vehicle detection process on road are used for vehicle tracking, counts, average speed of each individual vehicle, traffic analysis and vehicle categorizing objectives and may be implemented under different environments changes. In this review, we present a concise overview of image processing methods and analysis tools which used in building these previous mentioned applications that involved developing traffic surveillance systems. More precisely and in contrast with other reviews, we classified the processing methods under three categories for more clarification to explain the traffic systems.
Creating and evaluating genetic tests predictive of drug response
Creators: name: Johnson, Julie A.
name: Benowitz, Neal L.
name: Giacomini, Kathleen M.
name: Flockhart, David A.
name: Ratain, Mark J.
name: McLeod, Howard L.
name: Weiss, Scott T.
name: Dolan, M. Eileen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: A key goal of pharmacogenetics — the use of genetic variation to elucidate inter-individual variation in drug treatment response — is to aid the development of predictive genetic tests that could maximize drug efficacy and minimize drug toxicity. The completion of the Human Genome Project and the associated HapMap Project, together with advances in technologies for investigating genetic variation, have greatly advanced the potential to develop such tests; however, many challenges remain. With the aim of helping to address some of these challenges, this article discusses the steps that are involved in the development of predictive tests for drug treatment response based on genetic variation, and factors that influence the development and performance of these tests.
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008
Creators: name: Stevens, Raymond C.
name: Brooks, Charles L.
name: Michino, Mayako
name: Moult, John
name: Abola, Enrique
name: Dixon, J. Scott
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: With the recent breakthroughs in G protein-coupled receptor structure, one can now compare experimentally determined structures with the most recent modeling and docking methods. A community-wide blind prediction experiment (GPCR Dock 2008) was conducted in coordination with the publication of the human adenosine A2A receptor bound to the ligand ZM241385 crystal structure (Science 322, 1211 (2008)). Twenty-nine participating groups submitted 206 models that were evaluated for the accuracy of the ligand binding mode and the overall receptor model. Several new insights emerged including the critical importance of disulfide bonds in the extracellular loops, helix residue registry, and domain knowledge.
Drugging the undruggable RAS: Mission Possible?
Creators: name: Fesik, Stephen W.
name: Cox, Adrienne D.
name: Luo, Ji
name: Kimmelman, Alec C.
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Despite more than three decades of intensive effort, no effective pharmacologic inhibitors of the Ras oncoproteins have reached the clinic, prompting the widely held perception that Ras proteins are “undruggable”. However, there is renewed hope that this is not the case. In this review, we summarize the progress and promise of five key directions. First, we focus on the prospects of direct inhibitors of Ras. Second, we revisit the issue of whether blocking Ras membrane association is a viable approach. Third, we assess the status of targeting Ras downstream effector signalling, arguably the most favourable current direction. Fourth, we address whether the search for synthetic lethal interactors of mutant RAS still holds promise. Finally, Ras-mediated changes in cell metabolism have recently been described. Can these changes be exploited for new therapeutic directions? We conclude with perspectives on how additional complexities, not yet fully understood, may impact each of these approaches.
The exploration of phage-based therapeutics for multi-drug resistant bacterial pathogens
Creators: Davis, Carly Maddison
Publisher: name: University of Alberta Library
Year: 2022

Pathogenic bacteria have a plethora of mechanisms to survive within the human body, and the effectiveness of antibiotics to treat these infections is rapidly declining due to an increase in antimicrobial resistance (AMR) and a lack of new drug discovery. AMR is a significant global concern, and these infections are predicted to cause over 10 million deaths per year worldwide by 2050 if left unchecked. It is clear that alternative antibacterial strategies are desperately needed, and the therapeutic use of bacteriophages is a promising area of research. Phages are viruses that target and lyse bacterial cells via adsorption to cells using a cellular receptor, injecting their genetic material, and replicating themselves until the cell bursts. Phages use a different mechanism than antibiotics to kill bacteria, so many antibiotic resistance mechanisms carried by AMR bacteria provide no protection against phage infection. This means phages are an effective tool to kill drug-resistant bacteria, and unlike antibiotics, phages exclusively attack and lyse specific host bacteria, leaving beneficial bacterial flora unharmed. To explore the efficacy of phage as an alternative treatment option I examined the application of phages in combination with sub-inhibitory (non-lethal) levels of the antibiotic aztreonam lysine (AzLys) on Pseudomonas aeruginosa, a high priority member of the ESKAPE pathogens; a concerning group of pathogenic bacteria exhibiting multi-drug resistance and virulence, are responsible for the majority of nosocomial infections, and are associated with the highest risk of mortality. Activity of phages E79 and phiKZ were increased in the presence of aztreonam lysine, in part due to accelerated time to lysis. Sub-inhibitory AzLys negatively affected the function of surface virulence factors type 4 pili (T4P) and flagella, and the combined treatment of P. aeruginosa biofilms with E79 and non-lethal levels of AzLys was more effective than phage treatment alone. To continue investigating phage therapy, I assembled, annotated, and analyzed the complete iii genomes of two novel phages JC1 and Carl1 that can infect the deadly opportunistic pathogen Burkholderia cenocepacia. I further characterized JC1 and showed it possesses an impressive host range, uses the inner core of the LPS as its cellular surface receptor, and has a high virulence index at 37˚C. I also identified the attP site and location of integration in its bacterial host genome when it takes the form of a prophage. Genetic engineering of this phage could result in a promising phage therapy candidate for the treatment of B. cenocepacia infections. Continued research on the isolation, characterization, and application of phages is necessary so the use of phage as a therapy can become an accessible treatment option for chronic and antibiotic resistant infections.
Bouncing Universes: Simple Cosmological Models with a Scalar Field
Creators: Cukali, Elsad
Publisher: name: University of Alberta Library
Year: 2022

In this thesis, we consider a homogeneous and isotropic closed model of the Universe with a real massive scalar field. Hawking showed that if such a model of the Universe is fine-tuned, it can have an infinite number of bounces. We study the case for

the Universe that is microscopically time-symmetric about a homogeneous, isotropic bounce. We begin by considering a classical periodic solution in which a Universe has a time-symmetric bounce and expands to a large maximum size with a fixed large number of zero crossings of the scalar field between each pair of consecutive bounces.

After the inflation, the scalar field oscillates with a phase constant. The change in this oscillation phase will quantify a perturbation of the solution and we are seeking to find the probability for two successive bounces.
${\rm K}_{\rm S}^{0}$ and $Λ$ Production in Charged Particle Jets in p--Pb Collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV with ALICE
Creators: name: Zhang, Xiaoming
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We study the production of ${\rm K}_{\rm S}^{0}$ mesons and $Λ$ baryons in jets in p--Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV with ALICE at the LHC. The $p_{\rm T}$-differential density of the particles produced in jets is compared to the inclusive distributions and the $Λ/{\rm K}_{\rm S}^{0}$ ratio is reported in bins of multiplicity of the collisions. The hard scatterings are selected on an event-by-event basis using the anti-$k_{\rm T}$ clustering algorithm with resolution parameter $R=0.2,~0.3$ and $0.4$, reconstructed from charged particles with a minimum $p_{\rm T,jet}$ of $10$ (or $20$) GeV/$c$.
description: 4 pages, 2 figures, Quark Matter 2014 proceeding, submitted to Nucl. Phys. A
Effects of green nudges on consumer valuation of sustainable food : a discrete choice experiment
Creators: name: Gottselig, Valerija
name: Wuppermann, Amelie
name: Herrmann, Christoph
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 330

description: Sustainable nutrition is becoming increasingly relevant in society. This empirical study suggests that green nudges can encourage consumers to buy food that has an ecology or animal welfare label. This paper analyzes whether green nudges ‐ displaying nature pictures or providing information on other people’s behavior before the consumer makes a choice ‐ can promote more environmentally friendly food choices. Based on data from an online, discrete choice experiment conducted in Germany, in which randomly selected groups of participants were shown either one of the nudges (treatment groups) or no nudge (control group), the study finds that green nudges increase individuals’ willingness to pay more for products that have ecology and animal welfare labels. However, consumers in one of the treatment groups were willing to pay more for meat rather than the meat alternative, indicating that nudges can have an effect opposite from that intended. Future research should investigate the impact of these relatively cheap interventions with a representative sample and in a field setting.
Classification of separately continuous functions with values in $σ$-metrizable spaces
Creators: name: Karlova, Olena
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 54C08, 54C05, 54E20 54C08, 54C05, 54E20 54C08, 54C05, 54E20

description: We prove that every vertically nearly separately continuous function defined on a product of a strong PP-space and a topological space and with values in a strongly $σ$-metrizable space with a special stratification, is a pointwise limit of continuous functions.
Monitoraggio ambientale e controllo degli accessi attraverso una semplice applicazione in ambito Internet of Things
Creators: name: Cogorno, Andrea
name: Lattanzi, Emanuele
Publisher: name: Zenodo
Year: 2022
Subjects: Arduino IDE
DHT-11
ESP8266
InfluxDB
Python
Raspberry PI
Sense HAT

description: L’internet delle cose o Internet of Things (IoT) è ormai una tecnologia affermata e il suo potenziale è enorme.
 Possiamo considerare l’IoT una sorta di ”rete neurale universale” che col passare del tempo, permeerà ogni
 aspetto della nostra vita. L’IoT è composta da sensori, device e piccoli apparati intelligenti che interagiscono
 e comunicano con altre macchine, oggetti, ambienti e infrastrutture. Enormi volumi di dati vengono generati,
 elaborati e tradotti in azioni che possono gestire e controllare le cose (things) che ci circondano, per rendere la
 nostra vita molto più semplice e sicura; tuttavia, questo insieme di apparati e di tecnologie non è esente da criticità
 legate alla sicurezza e alla privacy dei dati e al consumo energetico necessario per la loro conservazione ed
 elaborazione. In questo articolo verrà illustrato un progetto per la realizzazione di una stazione di monitoraggio
 dei dati ambientali e di controllo degli accessi ad un’ipotetica sala server. Si tratta di un progetto molto
 accessibile sia dal punto di vista economico che sotto il profilo delle conoscenze informatiche necessarie per la
 sua implementazione. Allo stesso tempo, il progetto si presta a diversi possibili sviluppi e migliorie, sia dal punto
 di vista delle funzionalità che dell’ottimizzazione, anche grazie alla continua evoluzione dell’hardware e delle
 tecnologie che costituisco l’Internet of Things.
Smooth X-ray variability from $ρ$ Ophiuchi A+B. A strongly magnetized primary B2 star?
Creators: name: Pillitteri, Ignazio
name: Wolk, Scott J.
name: Goodman, Alyssa
name: Sciortino, Salvatore
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: X-rays from massive stars are ubiquitous yet not clearly understood. In an XMM-Newton observation devoted to observe the first site of star formation in the $ρ$ Ophiuchi dark cloud, we detect smoothly variable X-ray emission from the B2IV+B2V system of $ρ$ Ophiuchi. Tentatively we assign the emission to the primary component. The light curve of the pn camera shows a first phase of low, almost steady rate, then a rise phase of duration of 10 ks, followed by a high rate phase. The variability is seen primarily in the band 1.0-8.0 keV while little variability is detected below 1 keV. The spectral analysis of the three phases reveals the presence of a hot component at 3.0 keV that adds up to two relatively cold components at 0.9 keV and 2.2 keV. We explain the smooth variability with the emergence of an extended active region on the surface of the primary star due to its fast rotation (v $sin~i \sim315$ km/s). We estimate that the region has diameter in the range $0.5-0.6$ R$_*$. The hard X-ray emission and its variability hint a magnetic origin, as suggested for few other late-O$-$early-B type stars. We also discuss an alternative explanation based on the emergence from occultation of a young (5-10 Myr) low mass companion bright and hot in X-rays.
description: 4 pages, 3 figures, 2 tables. Accepted for publication as a letter in A&A
Equiconnected spaces and Baire classification of separately continuous functions and their analogs
Creators: name: Karlova, Olena
name: Maslyuchenko, Volodymyr
name: Mykhaylyuk, Volodymyr
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 54C08, 54C05, 54E20 54C08, 54C05, 54E20 54C08, 54C05, 54E20

description: We investigate the Baire classification of mappings $f:X\times Y\to Z$, where $X$ belongs to a wide class of spaces, which includes all metrizable spaces, $Y$ is a topological space, $Z$ is an equiconnected space, which are continuous in the first variable and for a dense set in $X$ these mappings are functions of a Baire class $α$ in the second variable.
1997-09-17, Letter from Steven L. DeVore to Robert Hard, Comments on Draft Survey Report for Archaeological Survey of Lackland Air Force Base, Texas, Draft
Creators: name: De Vore, Steven
Publisher: name: National Park Service, Intermountain Region
Year: 1997
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Lackland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78949/lackland-air-force-base
subject: Texas (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/348/texas-state-territory
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The National Park Service/Air Force (NPS/AF) and the Texas State Historic Preservation Office (SHPO) staffs have completed the review of the draft survey report for the archeological survey of Lackland Air Force Base. Included in this document are the general comments from the NPS/AF, the SHPO and the annotated comments on the draft report from the SHPO. Included in this correspondence was Jack Siegel at Randolph Air Force Base, Gabriel Gonzales at Lackland Air Force Base, and thomas Forsyth - contracting officer.
Robust Knowledge Acquisition in Answering Information-seeking Questions At Scale
Creators: Kamalloo, Ehsan
Publisher: name: University of Alberta Library
Year: 2022

Answering information-seeking question involves retrieving relevant documents from a massive haystack of unstructured text corpora. This dissertation aims at building question answering (QA) systems that can be deployed in the wild where incoming questions may be noisy and their distribution inevitably shifts from that of the training data. At a high level, we attempt to tackle three distinct problems arising in real-world scenarios: from the modelling perspective, how to build robust and scalable QA models, and how to acquire knowledge that is useful for fulfilling questions from text, and from the evaluation perspective, how to reliably evaluate retrieval-based QA models.

Towards this goal, we first study the problem of adapting classical IR models for QA tasks. For this purpose, we investigate one of the basic and salient linguistic features in text, the relationship between the ordering of words in an answer passage and that of a question. In particular, we present a sparse retrieval model that treats $n$-grams as single compound terms to represent local word order. Second, our focus shifts to the generalizability of QA models via data augmentation. To this end, we design a sample-efficient data augmentation framework, inspired by adversarial training methods, that makes QA models robust to distribution shift. Third, we present a novel knowledge acquisition method that can be helpful in addressing ambiguity in questions. In particular, we aim at automatically deriving meta-information about the spatial grounding of location mentions in text. Our method does not require any supervision and leverages the structural interactions between the mentions in a document. Finally, we focus on the reliability of evaluation benchmarks in information-seeking QA. Specifically, we highlight that existing benchmarks are heavily skewed toward passage-level information. Our analysis paves the way for designing future benchmarks that can better reflect the true performance of QA models.

Overall, in pursuit of achieving genuine human-level QA systems that can be readily used in real-world applications, the present thesis highlights the key requirements of knowledge acquisition, robustness to distribution shift, scalability, and reliable evaluation.