cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone
Creators: name: Peden, David B.
name: Wu, Weidong
name: Diaz-Sanchez, David
name: Kesic, Matt
name: Zhang, Wenli
name: Samet, James M.
name: Doreswamy, Vinod
name: Jaspers, Ilona
name: Dailey, Lisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Exposure to the major air pollutant ozone can aggravate asthma and other lung diseases. Our recent study in human volunteers has shown that the glutathione S-transferase mu 1 (GSTM1) null genotype is associated with increased airway neutrophilic inflammation induced by inhaled ozone. The aim of this study was to examine the effect of GSTM1 modulation on interleukin 8 (IL-8) production in ozone-exposed human bronchial epithelial cells (BEAS-2B) and the underlying mechanisms. Exposure of BEAS-2B cells to 0.4 ppm ozone for 4 h significantly increased IL-8 release with a modest reduction in intracellular reduced glutathione (GSH). Ozone exposure induced reactive oxygen species (ROS) production and NFκB activation. Pharmacological inhibition of NFκB activation or mutation of IL-8 promoter at κB-binding site significantly blocked ozone-induced IL-8 production or IL-8 transcriptional activity, respectively. Knockdown of GSTM1 in BEAS-2B cells enhanced ozone-induced NFκB activation and IL-8 production. Consistently, ozone-induced overt increase in IL-8 production was detected in GSTM1-null primary human bronchial epithelial cells. In addition, supplementation with reduced GSH inhibited ozone-induced ROS production, NFκB activation and IL-8 production. Taken together, GSTM1 deficiency enhances ozone-induced IL-8 production, which is mediated by generated ROS and subsequent NFκB activation in human bronchial epithelial cells.
Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment
Creators: name: Wu, Zhihao
name: Oveson, Brian C.
name: Choi, Eun-Young
name: Lee, Sun Young
name: Usui, Shinichi
name: Jo, Young-Joon
name: Lu, Lili
name: Iwase, Takeshi
name: Samulski, Richard J.
name: Campochiaro, Peter A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: In retinitis pigmentosa (RP), various mutations cause rod photoreceptor cell death leading to increased oxygen levels in the outer retina, progressive oxidative damage to cones, and gradual loss of cone cell function. We have been exploring the potential of overexpressing components of the endogenous antioxidant defense system to preserve cone cell function in rd10+/+ mice, a model of RP. Rd10+/+ mice deficient in superoxide dismutase 1 (SOD1) showed increased levels of superoxide radicals and carbonyl adducts (a marker of oxidative damage) in the retina, and more rapid loss of cone function than rd10+/+ mice with normal levels of SOD1. This suggests that SOD1 is an important component of the antioxidant defense system of cones, but increased expression of SOD1 in rd10+/+ mice increased oxidative damage and accelerated the loss of cone function. Co-expression of SOD1 with glutathione peroxidase 4 (Gpx4), which like SOD1 is localized in the cytoplasm, but not with catalase targeted to the mitochondria, reduced oxidative damage in the retina and significantly slowed the loss of cone cell function in rd10+/+ mice. Gene transfer resulting in increased expression of SOD2, but not co-expression of SOD2 and mitochondrial Gpx4, resulted in high levels of H2O2 in the retina. These data suggest that in order to provide benefit in RP, over-expression of a SOD must be combined with expression of a peroxide detoxifying enzyme in the same cellular compartment.
Detection of Ras GTPase protein radicals through immuno-spin trapping
Creators: name: Ehrenshaft, Marilyn
name: Davis, Michael F.
name: Gunawardena, Harsha P.
name: Chen, Xian
name: Ranguelova, Kalina
name: Bonini, Marcelo G.
name: Zhou, Li
name: Mason, Ronald P.
name: Campbell, Sharon L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Over the past decade immuno-spin trapping (IST) has been used to detect and identify protein radical sites in numerous heme and metalloproteins. To date, however, the technique has had little application toward non-metalloproteins. In this study, we demonstrate the successful application of IST in a system free of transition metals and present the first conclusive evidence of ·NO-mediated protein radical formation in the HRas GTPase. HRas is a non-metalloprotein that plays a critical role in regulating cell growth control. Protein radical formation in Ras GTPases has long been suspected of initiating premature release of bound guanine nucleotide. This action results in altered Ras activity both in vitro and in vivo. As described herein, successful application of IST may provide a means for detecting and identifying radical-mediated Ras activation in many different cancers and disease states where Ras GTPases play an important role.
"This is What Transparency Looks Like"? Opening Data, Including the Public, Aspiring for Accountability
Creators: name: Craft, Andrea
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Transparency in government is thought to be a fundamental prerequisite for accountability, or the obligation of public officials to answer to the public and be responsible for how they perform their duties in relation to those they represent. In an ‘explosion’ of transparency, public institutions are now investing heavily in transparency initiatives meant to foster public accountability through online data portals, legal requirements mandating disclosure, and innovations in community engagement and public participation, all designed to open up government to the public view. By all metrics, government transparency is increasing, but it regularly falls short in its aspirations for improved public trust, legitimacy, democratic engagement, and equity, a dilemma that transparency scholars struggle to resolve. Through a focus on local government transparency practices, this dissertation contributes to the understanding of why government transparency is not achieving accountability goals. It helps to refine transparency as a construct and uncover some of the challenges and limitations in how it is being practiced on the ground. My overarching research question is, “How is transparency enrolled in urban governance, and what are its implications for accountability?” I conducted a qualitative study of how transparency is being implemented in local government in Chicago, using primarily participant observation methods to examine several transparency projects active in Chicago between 2019 and 2022. I propose a model of transparency practices, which can be categorized into four modalities: disclosure, data, inclusion, and audit. I then look closely at two exceptionally opaque areas of local government - economic development and the criminal justice system – and show how opacity is being upheld by the tendency of transparency techniques to obscure power relations, but also how transparency can be enhanced by embracing the inherently political nature of data.
คนไทยกับมโนทัศน์การต่อสู้
Creators: name: นันทนา วงษ์ไทย
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: คนไทย
มโนทัศน์การต่อสู้
อุปลักษณ์

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 18, 2, 193-220
Role of GSTM1 in resistance to lung inflammation
Creators: name: Wu, Weidong
name: Diaz-Sanchez, David
name: Peden, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Lung inflammation resulting from oxidant/antioxidant imbalance is a common feature of many lung diseases. In particular, the role of enzymes regulated by the NF-E2-related factor 2 (Nrf2) transcription factor has recently received increased attention. Among these antioxidant genes, the glutathione S-transferase mu 1 (GSTM1) has been most extensively characterized since it has a null polymorphism which is highly prevalent in the population and associated with increased risk of inflammatory lung diseases. Present evidence suggests that GSTM1 acts through interactions with other genes and environmental factors, especially air pollutants. Here, we review GSTM1 gene expression and regulation and summarize the findings from epidemiological, clinical, animal and in vitro studies on the role played by GSTM1 in lung inflammation. We discuss limitations in the existing knowledge base and future perspectives and evaluate the potential of pharmacologic and genetic manipulation of the GSTM1 gene to modulate pulmonary inflammatory responses.
บทความแปล ว่าด้วยสังคมวิทยาเศรษฐกิจกับการวิพากษ์สังคม
Creators: name: วัชรพล พุทธรักษา
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: -

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 18, 2, 221-229
กลยุทธ์การสื่อสารของผู้เรียนภาษาญี่ปุ่นชาวไทย: กรณีฟังไม่เข้าใจ
Creators: name: พัชราพร แก้วกฤษฎางค์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: กลยุทธ์การสื่อสาร
กรณีฟังไม่เข้าใจ
ทักษะการฟังพูด
ความสุภาพในภาษาญี่ปุ่น

description: 1, 21, 1, 1-23
Glutathiolated Ras: Characterization and implications for Ras activation
Creators: name: Chen, Xian
name: Gunawardena, Harsha P.
name: Bonini, Marcelo G.
name: Campbell, Sharon L.
name: Hobbs, G. Aaron
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Ras GTPases cycle between active GTP-bound and inactive GDP-bound forms to regulate a multitude of cellular processes, including cell growth, differentiation, and apoptosis. The activation state of Ras is regulated by protein modulatory agents that accelerate the slow intrinsic rates of GDP dissociation and GTP hydrolysis. Similar to the action of guanine-nucleotide exchange factors, the rate of GDP dissociation can be greatly enhanced by the reaction of Ras with small-molecule redox agents, such as nitrogen dioxide, which can promote Ras activation. Nitrogen dioxide is an auto-oxidation product of nitric oxide and can react with an accessible cysteine of Ras to cause oxidation of the bound guanine nucleotide to facilitate Ras guanine nucleotide dissociation. Glutathione has also been reported to modify Ras and alter its activity. To elucidate the mechanism by which glutathione alters Ras guanine nucleotide binding properties, we performed NMR and biochemical analyses of glutathiolated Ras. We determined that treatment of H-Ras, lacking the non-conserved hypervariable region, with oxidized glutathione results in glutathiolation specifically at cysteine 118. However, glutathiolation does not alter Ras structure or biochemical properties. Rather, changes in guanine nucleotide binding properties and Ras activity occur upon exposure of Ras to free radicals, presumably through the generation of a cysteine 118 thiyl radical. Interestingly, Ras glutathiolation protects Ras from further free radical-mediated activation events. Therefore, glutathiolation does not affect Ras activity unless Ras is modified by glutathione through a radical-mediated mechanism. 1
Progetto di tirocinio laurea triennale in Fisica: Rilevamento automatico di scariche atmosferiche registrate negli spettrogrammi ‘CALLISTO’ tramite tecniche di machine-learning/deep-learning
Creators: name: MARASSI, Alessandro
name: Perin, Nicola
name: Milan, Andrea
name: Longo, Francesco
Publisher: name: O.A. Trieste
Year: 2023

description: Un solar radio burst (SRB) è un’ intensa emissione radio solare spesso correlata a un brillamento solare. Il rilevamento di SRBs puo’ essere effettuato tramite radiometri e spettrometri terrestri. CALLISTO e' uno spettrometro a basso costo progettato presso il Politecnico di Zurigo. Gli strumenti CALLISTO attivi in questo momento sono 67, distribuiti in tutto il mondo e permettono il monitoraggio delle emissioni radio solari 24h/7 tramite la rete e-Callisto http://www.e-callisto.org/. La Stazione Osservativa di Basovizza di INAF – Osservatorio Astronomico di Trieste e’ equipaggiata con tre spettrometri tipo CALLISTO operanti rispettivamente nelle bande VHF, UHF, L. E’ attivo anche un sistema sperimentale di rilevamento automatico di SRBs. I radiospettri acquisiti dagli spettrometri sono purtroppo affetti da disturbi ed interferenze a radio frequenza (RFI) che a volte vengono interpretati dal sistema come burst/falsi positivi. Tra questi le scariche atmosferiche, rilevate dagli spettrometri come emissioni lineari su tutto lo spettro. Il loro riconoscimento ed eliminazione puo’ contribuire in maniera importante a diminuire il numero di falsi positivi rilevati. Tra i vari possibili metodi di riconoscimento, tenuto anche conto del numero di eventi a disposizione per costruire un training set di numerosità adeguata, si e’ pensato di usare un sistema basato sul deep learning. Il lavoro effettuato nell’ambito del tirocinio, dopo l’acquisizione delle necessarie conoscenze di base (solar radio burst, documentazione CALLISTO, reti neurali, deep-learning) ha consentito la costruzione di training/test set di eventi ed una sperimentazione pilota su dati limitati con sviluppo ed esecuzione di modelli Keras su una virtual machine Virtualbox Ubuntu64 18.04 LTS, precedentemente installata ed attrezzata con librerie TensorFlow/Keras, propedeutica ad una sperimentazione completa su una Deep-Learning Machine fisica dedicata (CPU Xeon + GPU NVIDIA Quadro P4000).
การวิเคราะห์เชิงเปรียบต่างระหว่าง“กริยารูป teiku” ในภาษาญี่ปุ่น และ “กริยา + ไป” ในภาษาไทย: ข้อเสนอแนะสำหรับพัฒนาการสอนภาษาญี่ปุ่นสำหรับผู้เรียนชาวไทย
Creators: name: กนกวรรณ เลาหบูรณะกิจ คะตะกิริ
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: การวิเคราะห์เปรียบต่าง
ていく
กริยา ไป
ผู้เรียนภาษาญี่ปุ่นชาวไทย

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 24-58
Redox signaling in cardiovascular health and disease
Creators: name: Madamanchi, Nageswara R.
name: Runge, Marschall S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling pathways by reactive oxygen species (ROS) governs normal cardiovascular function. However, data from experimental and animal studies strongly support that dysregulated redox signaling, resulting from hyper-activation of various cellular oxidases or mitochondrial dysfunction, is integral to the pathogenesis and progression of cardiovascular disease (CVD). In this review, we address how redox signaling modulates the protein function, the various sources of increased oxidative stress in CVD, and the labyrinth of redox-sensitive molecular mechanisms involved in the development of atherosclerosis, hypertension, cardiac hypertrophy and heart failure, and ischemia–reperfusion injury. Advances in redox biology and pharmacology for inhibiting ROS production in specific cell types and subcellular organelles combined with the development of nanotechnology-based new in vivo imaging systems and targeted drug delivery mechanisms may enable fine-tuning of redox signaling for the treatment and prevention of CVD.
ความพึงพอใจของผู้เรียนต่อการทดลองใช้ภาษาเป้าหมาย ในการจัดการเรียนการสอนรายวิชาการออกเสียงภาษาญี่ปุ่น
Creators: name: ยุพกา ฟูกุชิม่า
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ความพึงพอใจของผู้เรียน
การใช้ภาษาเป้าหมาย
การออกเสียงภาษาญี่ปุ่น
ผู้สอนชาวไทย

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 59-89
Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers
Creators: name: Wagner, James G.
name: Peden, David B.
name: Alexis, Neil E.
name: Mills, Katherine
name: Kala, Aline
name: Zhou, Haibo
name: Zhang, Hongtao
name: Lay, John C.
name: Wells, Heather B.
name: Hernandez, Michelle L.
name: Jiang, Qing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Epidemiologic studies suggest that dietary vitamin E is an important candidate intervention for asthma. Our group has shown that daily consumption of vitamin E (gamma tocopherol, γT) has anti-inflammatory actions in both rodent and human phase I studies. The objective of this study was to test whether γT supplementation could mitigate a model of neutrophilic airway inflammation in rats and in healthy human volunteers.
Rapporto sulle Celebrazioni per i 250 anni dalla fondazione dell’Osservatorio Astronomico di Padova
Creators: name: ZAGGIA, Simone
name: BOCCATO, Caterina
name: ZANINI, Valeria
Publisher: name: O.A. Padova
Year: 2023

description: Nell’anno 2017 l'Osservatorio Astronomico di Padova ha celebrato i 250 anni dalla sua fondazione. Dall’inaugurazione del 21 marzo 2017 fino all’accensione della nuova illuminazione della Specola a fine settembre dello stesso anno è stato realizzato un nutrito programma di eventi pubblici che hanno coinvolto a vari livelli scienziati, autorità e il più largo pubblico. In questo rapporto descriviamo la rassegna “Specola 2.5.0”.
Semiconductor dielectric function, excitons and the Penn model
Creators: name: Cirilo-Lombardo, Diego Julio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Improved computation of the dielectric function considering excitonic effects and long wavelength is performed and compared with the nearly free electron band approximation, similarly with the Penn's model case. New expressions for the real and imaginary part of the dielectric function are presented and the real part compared with the Penn's result. The obtained functions satisfy the Kramers-Krönig relations, in contrast with earlier results in the literature. In addition, our improved dielectric function presents a coeficient of 2/3 for small gap approximation (different from the value of 1 in the original Penn model) is very close to the value 0.62 obtained in [Can. J. Phys.53,(1975) p.2549] from pure numerical procedures. The obtained dielectric function also is used in a rough and stimative analysis of the metal-insulator transition in molecular hydrogen being the critical densities determined near the experimental values for the hydrogen coming from other approach. The approximated expressions and critical values are given and the usefulness of the rough methods involved in the determination of the critical points briefly discussed.
description: Accepted for publication in the Philosophical Magazine, 10 pages, no figures
Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity
Creators: name: Oyamada, Nathaniel
name: Bruse, Shannon
name: Randell, Scott
name: Lin, Yong
name: Thompson, David C.
name: Jang, Jun-Ho
name: Liu, Yushi
name: Tesfaigzi, Yohannes
name: Matsumoto, Akiko
name: Zhang, Chunyu
name: Duffy, Veronica
name: Vasiliou, Vasilis
name: Nyunoya, Toru
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Aldehyde dehydrogenase 3A1 (ALDH3A1), an ALDH superfamily member, catalyzes the oxidation of reactive aldehydes, highly toxic components of cigarette smoke (CS). Even so, the role of ALDH3A1 in CS-induced cytotoxicity and DNA damage has not been examined. Among all of the ALDH superfamily members, ALDH3A1 mRNA levels showed the greatest induction in response to CS extract (CSE) exposure of primary human bronchial epithelial cells (HBECs). ALDH3A1 protein accumulation was accompanied by increased ALDH enzymatic activity in CSE-exposed immortalized HBECs. The effects of overexpression or suppression of ALDH3A1 on CSE-induced cytotoxicity and DNA damage (γH2AX) were evaluated in cultured immortalized HBECs. Enforced expression of ALDH3A1 attenuated cytotoxicity and downregulated γH2AX. siRNA-mediated suppression of ALDH3A1 blocked ALDH enzymatic activity and augmented cytotoxicity in CSE-exposed cells. Our results suggest that the availability of ALDH3A1 is important for cell survival against CSE in HBECs.
Degeneracy loci of twisted differential forms and linear line complexes
Creators: name: Tanturri, Fabio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14C05, 14J10, 14N15

description: We prove that the Hilbert scheme of degeneracy loci of pairs of global sections of Omega(2), the twisted cotangent bundle on P^(n-1), is unirational and dominated by the Grassmannian of lines in the projective space of skew-symmetric forms over a vector space of dimension n. We provide a constructive method to find the fibers of the dominant map. In classical terminology, this amounts to giving a method to realize all the pencils of linear line complexes having a prescribed set of centers. In particular, we show that the previous map is birational when n=4.
description: Postprint version
ความสามารถในการแปลความหมายระดับข้อความของ Google Translate ระบบ Neural Machine Translation จากภาษาญี่ปุ่นเป็นภาษาไทย
Creators: name: ณัฏฐิรา ทับทิม
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: การแปล
ภาษาระดับข้อความ
Google Translate
ระบบ Neural Machine Translation

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 90-113
The influence of regional strategic policy on municipal climate adaptation planning
Creators: Bonnett, Nicole
Birchall, S. Jeff
Publisher: name: University of Alberta Library
Year: 2022

This study examines extent and quality of climate adaptation integration within strategic plans of local governments in British Columbia, Canada. Strategic plans (n=39) were assessed using plan content analysis in order to understand whether regional planning leads to adaptation action by municipalities. Framed through an institutional resilience lens, we find regional policy guidance is critical for initiating uptake of municipal climate adaptation; however, lack of granular adaptation policies informed by appropriate climate data constrains implementation in practice. Through collaboration and leveraging strengths of different levels of government, adaptation barriers can be addressed and the quality of adaptation policies improved.
Reproductive success in Atlantic croaker, Micropogonias undulatus (Linnaeus), collected from Galveston Bay, Texas : study of a mixed contaminant estuary
Creators: name: Di Cocco, Jennifer Lynne, 1970-
Publisher: name: The University of Texas at Austin
Year: 1994
Subjects: subject: Atlantic croaker
subject: Texas
subject: Galveston Bay
subject: Reproduction
subject: FOS: Medical biotechnology
subject: Effect of water pollution
subject: Reproductive success
subject: Water pollution effect on reproduction
subject: Micropogonias undulatus
subject: San Jacinto Bay
subject: Tabbs Bay
subject: Bayport
subject: Atlantic croaker--Texas--Galveston Bay--Reproduction
subject: Atlantic croaker--Effect of water pollution on--Texas--Galveston Bay

description: The reproductive success of Atlantic croaker, Micropogonias undulatus, collected from two sites in the northwest section of the Houston Ship Channel and one site in Bayport Ship Channel in Galveston Bay, Texas was assessed in October 1993. Contaminant levels at the sites differ due to the amount and type of anthropogenic discharge along the Channel itself and in adjacent bays, with the San Jacinto and Tabbs Bay areas being heavily contaminated and Bayport Channel less contaminated. Individual spawns from sixty pairs of adult fish were inspected for egg quality and success of fertilization, hatch, and 39 and 63 h survival. Tabbs Bay had the highest percentage of unsuccessful spawns, 70.8%, followed by Bayport (32.0%), and San Jacinto (18.2%). Hatch was the critical time point in development due to the low success for all three sites (68.0% Bayport, 45.8% Tabbs Bay, 81.2% San Jacinto). San Jacinto had the most abnormal larvae at hatch, 26.3%, while Tabbs Bay had the highest percentage of dead abnormal larvae at 63 h, 51.8%. Less than 10% of the larvae at Bayport showed morphological abnormalities at any time point. Observations of larval response to a water jet or sound stimulation showed increasing trends with age of the larvae at Bayport Channel. At Tabbs Bay, there was evidence of impaired behavioral response as the larvae aged to both water jet and sound stimulation. Ovarian levels of ascorbic acid were significantly lower in the Tabbs Bay fish relative to those from the other sites. Conditions of the Houston Ship Channel in the Tabbs Bay region during October 1993 were detrimental to the reproductive success of M. undulatus, exerting the most influence at hatching of the embryo. Due to the physical and ecological similarities between sites, it is thought that the differing contaminant loads contributed to the differences seen between sites in larval survival, abnormalities, behavioral response, and adult ovarian ascorbic acid levels
MPEC 2023-U138 : 2022 SQ6
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Neuronal uptake of nanoformulated superoxide dismutase and attenuation of angiotensin II-dependent hypertension after central administration
Creators: name: Ahmad, Iman M.
name: Manickam, Devika S.
name: Kabanov, Alexander V.
name: Zimmerman, Matthew C.
name: Tian, Jun
name: Savalia, Krupa
name: Rosenbaugh, Erin G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Excessive production of superoxide (O2•−) in the central nervous system has been widely implicated in the pathogenesis of cardiovascular diseases, including chronic heart failure and hypertension. In an attempt to overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2•− scavenging enzyme, copper/zinc superoxide dismutase (CuZnSOD), in which CuZnSOD protein is electrostatically bound to poly-L-lysine (PLL50)-polyethylene glycol (PEG) block co-polymer to form CuZnSOD nanozyme. Different formulations of CuZnSOD nanozyme are covalently stabilized by either reducible or non-reducible crosslinked bonds between the PLL50-PEG polymers. Herein, we tested the hypothesis that PLL50-PEG CuZnSOD nanozyme delivers active CuZnSOD protein to neurons and decreases blood pressure in a mouse model of AngII-dependent hypertension. As determined by electron paramagnetic resonance (EPR) spectroscopy, nanozymes retain full SOD enzymatic activity as compared to native CuZnSOD protein. Non-reducible CuZnSOD nanozyme delivers active CuZnSOD protein to central neurons in culture (CATH.a neurons) without inducing significant neuronal toxicity. In vivo studies conducted in adult male C57BL/6 mice demonstrate that hypertension established by chronic subcutaneous infusion of AngII is significantly attenuated for up to 7 days following a single intracerebroventricular (ICV) injection of non-reducible nanozyme. These data indicate the efficacy of non-reducible PLL50-PEG CuZnSOD nanozyme in counteracting excessive O2•− and decreasing blood pressure in AngII-dependent hypertensive mice following central administration. Additionally, this study supports the further development of PLL50-PEG CuZnSOD nanozyme as an antioxidant-based therapeutic option for hypertension.
Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats
Creators: name: Birmingham, Neil P.
name: Harkema, Jack R.
name: Peden, David B.
name: Wagner, James G.
name: Jackson-Humbles, Daven
name: Jiang, Qing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Neutrophil-mediated tissue injury is a shared pathogenesis of both chronic pulmonary diseases and acute responses to pathogens, allergens, and airborne pollutants. Interventions to minimize toxic effects of neutrophil-derived oxidants and proteases are usually limited to corticosteroids, which can have adverse side effects. We used a rodent model of endotoxin-induced lung injury to test the hypothesis that the dietary supplement γ-tocopherol (γT), a natural form of vitamin E with antioxidant and novel anti-inflammatory properties, will protect from adverse nasal and pulmonary inflammatory responses induced by endotoxin (lipopolysaccharide; LPS). Male Fisher F344 rats were intranasally (i.n.) instilled with LPS for 2 consecutive days. Beginning 2 days before i.n. LPS, the rats were gavaged daily with 30 mg/kg γT. Twenty-four hours after the last i.n. LPS, bronchoalveolar lavage fluid (BALF) was collected, and pulmonary and nasal tissues were analyzed for gene expression and morphometric analyses of neutrophils and intraepithelial mucosubstances (IM). LPS caused increased BALF total cells (70% increase), neutrophils (300%), protein (35%), PGE2 (500%), and secreted mucins (75%). Robust increases in neutrophils and IM were detected in conducting airways. Pulmonary expression of MUC5AC, MIP-2, CINC-1, and MCP-1 was elevated three- to eightfold by LPS. Treatment with γT inhibited LPS-induced increases in BALF total cells, neutrophils, protein, PGE2, and secreted mucins, as well as IM and tissue neutrophil influx. Furthermore γT induced the expression of the regulatory cytokines IL-10 and IFN-γ while decreasing MUC5AC, MIP-2, CINC-1, and MCP-1. These data demonstrate novel therapeutic effects of the dietary vitamin E γT promoting anti-inflammatory pathways to protect from neutrophil-mediated lung injury.
กลวิธีการแปลคำว่า “ต้อง” เป็นภาษาญี่ปุ่นและการแปล なければならない เป็นภาษาไทย
Creators: name: กรรณิกา จิตรโสภา
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: กลวิธีการแปล
ต้อง
なければならない
ความหมายเชิงอรรถศาสตร์และความหมายเชิงวัจนปฏิบัติศาสตร์

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 114-143
α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice
Creators: name: Hiller, Sylvia
name: DeKroon, Robert
name: Simington, Stephen
name: Maeda, Nobuyo
name: Yi, Xianwen
name: Winnik, Witold
name: Xu, Longquan
name: Robinette, Jennifer
name: Alzate, Oscar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Hypothermia is a key symptom of sepsis, but the mechanism(s) leading to hypothermia during sepsis is largely unknown and thus no effective therapy is available for hypothermia. Therefore, it is important to investigate the mechanisms and develop effective therapeutic methods. Lipopolysaccharide (LPS)-induced hypothermia accompanied by excess nitric oxide (NO) production, lead to a reduction in energy production in wild type mice. However, mice lacking inducible nitric oxide synthase did not suffer from LPS-induced hypothermia, suggesting that hypothermia is associated with excess NO production during sepsis. This observation is supported by the treatment of wild type mice with α-lipoic acid (LA) in that it effectively attenuates LPS-induced hypothermia with decreased NO production. We also found that LA partially restored ATP production, and activities of the mitochondrial enzymes involved in energy metabolism, which were inhibited during sepsis. These data suggest that hypothermia is related to mitochondrial dysfunction, which is likely compromised by excess NO production and that LA administration attenuates hypothermia mainly by protecting mitochondrial enzymes from NO damage.
Heat kernel estimates for random walks with degenerate weights
Creators: name: Andres, Sebastian
name: Deuschel, Jean-Dominique
name: Slowik, Martin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 39A12, 60J35, 60K37, 82C41

description: We establish Gaussian-type upper bounds on the heat kernel for a continuous-time random walk on a graph with unbounded weights under an ergodicity assumption. For the proof we use Davies' perturbation method, where we show a maximal inequality for the perturbed heat kernel via Moser iteration.
description: 24 pages; in this version we corrected statement and proof of Theorem 1.10 and removed a minor technical gap in the iteration argument
Growing Resilient: The potential of urban agriculture for increasing food security and improving earthquake recovery
Creators: Slater, Tara
Birchall, S. Jeff
Publisher: name: University of Alberta Library
Year: 2022

Following an earthquake, urban agriculture has been shown to improve recovery by increasing food security and providing

numerous community and social benefits. However, many communities often do not consider urban agriculture within their

earthquake or disaster preparedness programs. This work explores the intersection between those two realms, considering how their integration may increase food security and improve resilience following an earthquake. Through a case study focusing on the City of Vancouver, British Columbia, Canada, this research involved a four-step strategic scan of planning and earthquake management documents to determine whether Vancouver has captured the benefit of urban agriculture for earthquake recovery. Results revealed that this benefit has yet to be realized, however there is ample opportunity to do so given the City’s advances in urban agriculture. This research seeks to provide planners, city officials and emergency management with insight into the potential of urban agriculture for earthquake preparedness. More broadly, this work seeks to add to the discussion by exploring a tangible integration of two realms that are often planned in isolation, yet could have positive impacts if combined. This paper concludes with specific interventions for how urban agriculture can be utilized for earthquake recovery in order to build resilience.
Redox regulation of Rac1 by thiol oxidation
Creators: name: Hobbs, G. Aaron
name: Arrington, Megan E.
name: Cox, Adrienne D.
name: DeCristo, Molly J.
name: Campbell, Sharon L.
name: Chen, Xian
name: Loeser, Richard F.
name: Mitchell, Lauren E.
name: Gunawardena, Harsha P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The Rac1 GTPase is an essential and ubiquitous protein that signals through numerous pathways to control critical cellular processes, including cell growth, morphology, and motility. Rac1 deletion is embryonic lethal, and its dysregulation or mutation can promote cancer, arthritis, cardiovascular disease, and neurological disorders. Rac1 activity is highly regulated by modulatory proteins and posttranslational modifications. Whereas much attention has been devoted to guanine nucleotide exchange factors that act on Rac1 to promote GTP loading and Rac1 activation, cellular oxidants may also regulate Rac1 activation by promoting guanine nucleotide exchange. Herein, we show that Rac1 contains a redox-sensitive cysteine (Cys18) that can be selectively oxidized at physiological pH because of its lowered pKa. Consistent with these observations, we show that Rac1 is glutathiolated in primary chondrocytes. Oxidation of Cys18 by glutathione greatly perturbs Rac1 guanine nucleotide binding and promotes nucleotide exchange. As aspartate substitutions have been previously used to mimic cysteine oxidation, we characterized the biochemical properties of Rac1C18D. We also evaluated Rac1C18S as a redox-insensitive variant and found that it retains structural and biochemical properties similar to those of Rac1WT but is resistant to thiol oxidation. In addition, Rac1C18D, but not Rac1C18S, shows greatly enhanced nucleotide exchange, similar to that observed for Rac1 oxidation by glutathione. We employed Rac1C18D in cell-based studies to assess whether this fast-cycling variant, which mimics Rac1 oxidation by glutathione, affects Rac1 activity and function. Expression of Rac1C18D in Swiss 3T3 cells showed greatly enhanced GTP-bound Rac1 relative to Rac1WT and the redox-insensitive Rac1C18S variant. Moreover, expression of Rac1C18D in HEK-293T cells greatly promoted lamellipodia formation. Our results suggest that Rac1 oxidation at Cys18 is a novel posttranslational modification that upregulates Rac1 activity.
Gaussian variational ansatz in the problem of anomalous sea waves: Comparison with direct numerical simulations
Creators: name: Ruban, V. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: The nonlinear dynamics of an obliquely oriented wave packet at sea surface is studied both analytically and numerically for various initial parameters of the packet, in connection with the problem of oceanic rogue waves. In the framework of Gaussian variational ansatz applied to the corresponding (1+2D) hyperbolic nonlinear Schrödinger equation, a simplified Lagrangian system of differential equations is derived, which determines the evolution of coefficients of the real and imaginary quadratic forms appearing in the Gaussian. This model provides a semi-quantitative description for the process of nonlinear spatio-temporal focusing, which is one of the most probable mechanisms of rogue wave formation in random wave fields. The system is integrated in quadratures, which fact allows us to understand qualitative differences between the linear and nonlinear regimes of the focusing of wave packet. Comparison of the Gaussian model predictions with results of direct numerical simulation of fully nonlinear long-crested water waves is carried out.
description: revtex4, 7 pages, 10 figures, accepted to JETP
MPEC 2023-P03 : EDITORIAL NOTICE: DIGEST2 UPDATES
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
กระบวนจินตภาพในความเรียงของนิ้วกลม
Creators: name: รุ่งฤดี แผลงศร
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: กระบวนจินตภาพ
ความเรียง
นิ้วกลม

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 144-172
Integrative analysis of multi-dimensional imaging genomics data for Alzheimer's disease prediction
Creators: name: Huang, Heng
name: Shen, Dinggang
name: Zhang, Ziming
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In this paper, we explore the effects of integrating multi-dimensional imaging genomics data for Alzheimer's disease (AD) prediction using machine learning approaches. Precisely, we compare our three recent proposed feature selection methods [i.e., multiple kernel learning (MKL), high-order graph matching based feature selection (HGM-FS), sparse multimodal learning (SMML)] using four widely-used modalities [i.e., magnetic resonance imaging (MRI), positron emission tomography (PET), cerebrospinal fluid (CSF), and genetic modality single-nucleotide polymorphism (SNP)]. This study demonstrates the performance of each method using these modalities individually or integratively, and may be valuable to clinical tests in practice. Our experimental results suggest that for AD prediction, in general, (1) in terms of accuracy, PET is the best modality; (2) Even though the discriminant power of genetic SNP features is weak, adding this modality to other modalities does help improve the classification accuracy; (3) HGM-FS works best among the three feature selection methods; (4) Some of the selected features are shared by all the feature selection methods, which may have high correlation with the disease. Using all the modalities on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, the best accuracies, described as (mean ± standard deviation)%, among the three methods are (76.2 ± 11.3)% for AD vs. MCI, (94.8 ± 7.3)% for AD vs. HC, (76.5 ± 11.1)% for MCI vs. HC, and (71.0 ± 8.4)% for AD vs. MCI vs. HC, respectively.
การเปรียบเทียบเสียงผู้พูดภาษาไทยด้วยระยะทางแบบยูคลิก: กรณีศึกษาค่าทางกลสัทศาสตร์ด้านระยะเวลา
Creators: name: ธนศักดิ์ ศิริคะเณรัตน์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: นิติสัทศาสตร์
กลสัทศาสตร์
การพิสูจน์หลักฐาน
หลักฐานเสียงพูด
การเปรียบเทียบเสียงผู้พูด

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 173-188
A Standard Basis Operator Equation of Motion Impurity Solver for Dynamical Mean Field Theory
Creators: name: Li, Hengyue
name: Tong, Ning-Hua
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present an efficient impurity solver for the dynamical mean-field theory (DMFT). It is based on the separation of bath degrees of freedom into the low energy and the high energy parts. The former is solved exactly using exact diagonalization and the latter is treated approximately using Green's function equation of motion decoupling approximation. The two parts are combined coherently under the standard basis operator formalism. The impurity solver is applied to the Anderson impurity model and, combined with DMFT, to the one-band Hubbard model. Qualitative agreement is found with other well established methods. Some promising features and possible improvements of the present solver are discussed.
description: 11 pages, 5 figures
สังข์ทองตอนกำเนิดพระสังข์: กรณีศึกษาสุวรรณสังขชาดกสังข์ทองฉบับพระราชนิพนธ์ และนิทานเรื่องกำเนิดพระสังข์
Creators: name: ศุภธัช คุ้มครอง
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: สังข์ทอง
สุวรรณสังขชาดก
สังข์ทองฉบับพระราชนิพนธ์
กำเนิดพระสังข์

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 189-213
Subclass-based multi-task learning for Alzheimer's disease diagnosis
Creators: name: Shen, Dinggang
name: Suk, Heung-II
name: Lee, Seong-Whan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In this work, we propose a novel subclass-based multi-task learning method for feature selection in computer-aided Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI) diagnosis. Unlike the previous methods that often assumed a unimodal data distribution, we take into account the underlying multipeak1 distribution of classes. The rationale for our approach is that it is highly likely for neuroimaging data to have multiple peaks or modes in distribution, e.g., mixture of Gaussians, due to the inter-subject variability. In this regard, we use a clustering method to discover the multipeak distributional characteristics and define subclasses based on the clustering results, in which each cluster covers a peak in the underlying multipeak distribution. Specifically, after performing clustering for each class, we encode the respective subclasses, i.e., clusters, with their unique codes. In encoding, we impose the subclasses of the same original class close to each other and those of different original classes distinct from each other. By setting the codes as new label vectors of our training samples, we formulate a multi-task learning problem in a ℓ2,1-penalized regression framework, through which we finally select features for classification. In our experimental results on the ADNI dataset, we validated the effectiveness of the proposed method by improving the classification accuracies by 1% (AD vs. Normal Control: NC), 3.25% (MCI vs. NC), 5.34% (AD vs. MCI), and 7.4% (MCI Converter: MCI-C vs. MCI Non-Converter: MCI-NC) compared to the competing single-task learning method. It is remarkable for the performance improvement in MCI-C vs. MCI-NC classification, which is the most important for early diagnosis and treatment. It is also noteworthy that with the strategy of modality-adaptive weights by means of a multi-kernel support vector machine, we maximally achieved the classification accuracies of 96.18% (AD vs. NC), 81.45% (MCI vs. NC), 73.21% (AD vs. MCI), and 74.04% (MCI-C vs. MCI-NC), respectively.
MPEC 2023-U139 : 2023 OF2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Renormalization for autonomous nearly incompressible BV vector fields in 2D
Creators: name: Bianchini, Stefano
name: Bonicatto, Paolo
name: Gusev, Nikolay A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35F10, 35L03, 28A50

description: Given a bounded autonomous vector field $b \colon \mathbb R^d \to \mathbb R^d$, we study the uniqueness of bounded solutions to the initial value problem for the related transport equation \begin{equation*} \partial_t u + b \cdot \nabla u= 0. \end{equation*} We are interested in the case where $b$ is of class BV and it is nearly incompressible. Assuming that the ambient space has dimension $d=2$, we prove uniqueness of weak solutions to the transport equation. The starting point of the present work is the result which has been obtained in \cite{BG} (where the \emph{steady} case is treated). Our proof is based on splitting the equation onto a suitable partition of the plane: this technique was introduced in \cite{ABC1}, using the results on the structure of level sets of Lipschitz maps obtained in \cite{ABC2}. Furthermore, in order to construct the partition, we use Ambrosio's superposition principle \cite{ambrosiobv}.
description: 39 pages, 2 figures