cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of A comprehensive overview of the cystic fibrosis on the island of São Miguel (Azores, Portugal)
Creators: name: Rosa, Joana
name: Gaspar-Silva, Patrícia
name: Pacheco, Paula
name: Silva, Conceição
name: Branco, Cláudia
name: Vieira, Barbara
name: Carreiro, Alexandra
name: Gonçalves, Juan
name: Mota-Vieira, Luisa
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Plant Biology

description: Additional file 1: Table S1. Primers and PCR conditions for genotyping CFTR mutations in the general population of São Miguel.
Characterization of a Recombinant Adeno-Associated Virus Type 2 Reference Standard Material
Creators: name: Darmon, Christophe
name: Chtarto, Abdelwahed
name: Doria, Monica
name: Conlon, Thomas
name: Philipsberg, Tina
name: Beecham, E. Jeffrey
name: Clark, K. Reed
name: Leuchs, Barbara
name: Douar, Anne
name: Korn, Michael T.
name: Chiorini, John A.
name: Leon, Xavier
name: Bose, Mahuya
name: Giacca, Mauro
name: Francis, Joyce D.
name: Lock, Martin
name: Korytov, Irina
name: Müller, Marcus
name: Blouin-Tavel, Véronique
name: Moullier, Philippe
name: Auricchio, Alberto
name: Ozawa, Keiya
name: Melas, Catherine
name: Lux, Gabriele
name: Byrne, Barry J.
name: McGorray, Susan
name: Bosch, Fatima
name: Flotte, Terence R.
name: Francois, Achille
name: Caton, Tina
name: Ayuso, Eduard
name: Mizukami, Hiroaki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A recombinant adeno-associated virus serotype 2 Reference Standard Material (rAAV2 RSM) has been produced and characterized with the purpose of providing a reference standard for particle titer, vector genome titer, and infectious titer for AAV2 gene transfer vectors. Production and purification of the reference material were carried out by helper virus–free transient transfection and chromatographic purification. The purified bulk material was vialed, confirmed negative for microbial contamination, and then distributed for characterization along with standard assay protocols and assay reagents to 16 laboratories worldwide. Using statistical transformation and modeling of the raw data, mean titers and confidence intervals were determined for capsid particles ({X}, 9.18 × 1011 particles/ml; 95% confidence interval [CI], 7.89 × 1011 to 1.05 × 1012 particles/ml), vector genomes ({X}, 3.28 × 1010 vector genomes/ml; 95% CI, 2.70 × 1010 to 4.75 × 1010 vector genomes/ml), transducing units ({X}, 5.09 × 108 transducing units/ml; 95% CI, 2.00 × 108 to 9.60 × 108 transducing units/ml), and infectious units ({X}, 4.37 × 109 TCID50 IU/ml; 95% CI, 2.06 × 109 to 9.26 × 109 TCID50 IU/ml). Further analysis confirmed the identity of the reference material as AAV2 and the purity relative to nonvector proteins as greater than 94%. One obvious trend in the quantitative data was the degree of variation between institutions for each assay despite the relatively tight correlation of assay results within an institution. This relatively poor degree of interlaboratory precision and accuracy was apparent even though attempts were made to standardize the assays by providing detailed protocols and common reagents. This is the first time that such variation between laboratories has been thoroughly documented and the findings emphasize the need in the field for universal reference standards. The rAAV2 RSM has been deposited with the American Type Culture Collection and is available to the scientific community to calibrate laboratory-specific internal titer standards. Anticipated uses of the rAAV2 RSM are discussed.
Efficient Retrograde Transport of Adeno-Associated Virus Type 8 to Spinal Cord and Dorsal Root Ganglion After Vector Delivery in Muscle
Creators: name: Li, Jianbin
name: Xiao, Xiao
name: Wang, Chi-Hsien
name: Zhang, Cheng
name: Li, Juan
name: Yuan, Zhenhua
name: Qiao, Chunping
name: Zheng, Hui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The peripheral nervous system (PNS), including peripheral nerves and dorsal root ganglion (DRG), is involved in numerous neurological disorders, such as peripheral neuropathies (diabetic neuropathy, chronic pain, etc.) and demyelination diseases (multiple sclerosis, congenital muscular dystrophy, Charcot-Marie-Tooth disease, etc.). Effective clinical interventions for those diseases are very limited. Gene therapy represents a novel therapeutic strategy for the PNS diseases, especially with simply and minimally invasive delivery methods. Previously, we have shown that adeno-associated virus type 8 (AAV8) can efficiently transduce muscles body wide by a simple intraperitoneal injection in neonatal mice. In this study, we investigated the capacity of AAV8 in transducing PNS in neonatal mice by intraperitoneal injection and also in adult mice by intramuscular injection. Efficient and long-term gene transfer was found in the white matter of the spinal cord, DRG neurons, and peripheral nerves in both groups, treated either as neonates or as adults, particularly neonates. In the adult mice injected with AAV8 in tibialis anterior and gastrocnemius muscles in one of the hind legs, more neurons were transduced in the lower part of the spinal cord than in the upper part; the DRG neurons were transduced more on the vector-injected side than in the contralateral uninjected side. Few cells in the gray matter of the spinal cord were transduced regardless of the delivery methods and age of the mice. These results support the mechanism of vector retrograde transport and suggest that AAV8 crosses blood–nerve barrier poorly. Our finding should have important implications in gene therapy for peripheral neurological disorders.
MOESM2 of A comprehensive overview of the cystic fibrosis on the island of São Miguel (Azores, Portugal)
Creators: name: Rosa, Joana
name: Gaspar-Silva, Patrícia
name: Pacheco, Paula
name: Silva, Conceição
name: Branco, Cláudia
name: Vieira, Barbara
name: Carreiro, Alexandra
name: Gonçalves, Juan
name: Mota-Vieira, Luisa
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Additional file 2: Table S2. Additional demographic, clinical characteristics and genetic data of each CF patient.
MOESM3 of A comprehensive overview of the cystic fibrosis on the island of São Miguel (Azores, Portugal)
Creators: name: Rosa, Joana
name: Gaspar-Silva, Patrícia
name: Pacheco, Paula
name: Silva, Conceição
name: Branco, Cláudia
name: Vieira, Barbara
name: Carreiro, Alexandra
name: Gonçalves, Juan
name: Mota-Vieira, Luisa
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Plant Biology

description: Additional file 3: Table S3. Genotypes and genetic backgrounds of CF patients with the p.Ser4Ter, p.Gln1100Pro or c.120del23, found in the literature and in the ClinVar database [27–35].
α-Fetoprotein Gene Delivery to the Nasal Epithelium of Nonhuman Primates by Human Parainfluenza Viral Vectors
Creators: name: Zhang, Liqun
name: Wilson, James M.
name: Antunes, Marcelo B.
name: Collins, Peter L.
name: Limberis, Maria P.
name: Pickles, Raymond J.
name: Thompson, Catherine
name: Luongo, Cindy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Over the last two decades, enormous effort has been focused on developing virus-based gene delivery vectors to target the respiratory airway epithelium as a potential treatment for cystic fibrosis (CF) lung disease. However, amongst other problems, the efficiency of gene delivery to the differentiated airway epithelial cells of the lung has been too low for clinical benefit. Although not a target for CF therapy, the nasal epithelium exhibits cellular morphology and composition similar to that of the lower airways, thus representing an accessible and relevant tissue target for evaluating novel and improved gene delivery vectors. We previously reported that replication-competent human parainfluenza virus (PIV)-based vectors efficiently deliver the cystic fibrosis transmembrane conductance regulator gene to sufficient numbers of cultured CF airway epithelial cells to completely correct the bioelectric function of CF cells to normal levels, resulting in restoration of mucus transport. Here, using an in vitro model of rhesus airway epithelium, we demonstrate that PIV mediates efficient gene transfer in rhesus epithelium as in the human counterpart. Naive rhesus macaques were inoculated intranasally with a PIV vector expressing rhesus macaque α-fetoprotein (rhAFP), and expression was monitored longitudinally. rhAFP was detected in nasal lavage fluid and in serum samples, indicating that PIV-mediated gene transfer was effective and that rhAFP was secreted into both mucosal and serosal compartments. Although expression was transient, lasting up to 10 days, it paralleled virus replication, suggesting that as PIV was cleared, rhAFP expression was lost. No adverse reactions or signs of discomfort were noted, and only mild, transient elevations of a small number of inflammatory cytokines were measured at the peak of virus replication. In summary, rhAFP proved suitable for monitoring in vivo gene delivery over time, and PIV vectors appear to be promising airway-specific gene transfer vehicles that warrant further development.
Hybrid ML-EMT Based Digital Twin for Device-Level HIL Real-Time Emulation of Ship-Board Microgrid on FPGA
Creators: Songyang Zhang, Tian Liang, Venkata Dinavahi
Publisher: name: University of Alberta Library
Year: 2023

Maritime industries desire high speed and reliability, low lifespan cost, and environmental impact shipping for transportation. Compared to highly congested land shipments and high-cost air freight, all-electric ship (AES) can reduce the lifespan energy consumption and transport a considerable freight volume at a lower rate. Recently, the medium voltage DC (MVDC) topology, recommended by IEEE standard, pushes the AES to the next stage in considering space and weight constraints with the reduction of bulky transformers and simplified parallel connections. However, device-level modeling of this massive parallel MVDC-based ship-board microgrid (SBM) is challenging to both the state-of-the-art general-purpose compute unit and traditional electromagnetic transient (EMT) based emulation. With the rapid development of machine learning (ML) algorithm and its dedicated execution unit, accelerated parallel emulation becomes achievable in different levels of this paralleled connected SBM. Applying the ML-aided technique can help to improve the emulation execution efficiency and reduce the consumption of hardware resource on the field-programmable gate arrays (FPGAs). This work proposes a real-time hybrid ML-EMT based digital twin of the complete SBM at the subsystem-level and equipment-level with validated results from PSCAD/EMTDC, and device-level with validated results from SaberRD.
Coherent-state path integral versus coarse-grained effective stochastic equation of motion: From reaction diffusion to stochastic sandpiles
Creators: name: Wiese, Kay Jörg
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We derive and study two different formalisms used for non-equilibrium processes: The coherent-state path integral, and an effective, coarse-grained stochastic equation of motion. We first study the coherent-state path integral and the corresponding field theory, using the annihilation process $A+A\to A$ as an example. The field theory contains counter-intuitive quartic vertices. We show how they can be interpreted in terms of a first-passage problem. Reformulating the coherent-state path integral as a stochastic equation of motion, the noise generically becomes imaginary. This renders it not only difficult to interpret, but leads to convergence problems at finite times. We then show how alternatively an effective coarse-grained stochastic equation of motion with real noise can be constructed. The procedure is similar in spirit to the derivation of the mean-field approximation for the Ising model, and the ensuing construction of its effective field theory. We finally apply our findings to stochastic Manna sandpiles. We show that the coherent-state path integral is inappropriate, or at least inconvenient. As an alternative, we derive and solve its mean-field approximation, which we then use to construct a coarse-grained stochastic equation of motion with real noise.
description: 29 pages, 33 figures. This is a pedagogic introduction to stochastic processes, their modeling, and effective field theory. Version 2: writing improved + a new appendix
Galaxy-halo size relation from Sloan Digital Sky Survey Data Release 7 and the ELUCID simulation
Creators: name: Zhang, Youcai
name: Yang, Xiaohu
name: Guo, Hong
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Based on galaxies in the Sloan Digital Sky Survey Data Release 7 (SDSS DR7) and dark matter haloes in the dark matter only, cosmological and constrained ELUCID simulation, we investigate the relation between the observed radii of central galaxies with stellar mass $\gtrsim 10^{8} h^{-2}{\rm M}_\odot$ and the virial radii of their host dark matter haloes with virial mass $\gtrsim 10^{10.5} h^{-1}{\rm M}_\odot$, and the dependence of galaxy-halo size relation on the halo spin and concentration. Galaxies in observation are matched to dark matter (sub-)haloes in the ELUCID simulation using a novel neighborhood subhalo abundance matching method. For galaxy 2D half-light radii $R_{50}$, we find that early- and late-type galaxies have the same power-law index 0.55 with $R_{50} \propto R_{\rm vir}^{0.55}$, although early-type galaxies have smaller 2D half-light radii than late-type galaxies at fixed halo virial radii. When converting the 2D half-light radii $R_{50}$ to 3D half-mass radii $r_{1/2}$, both early- and late-type galaxies display similar galaxy-halo size relations with $\log r_{1/2} = 0.55 \log (R_{\rm vir}/210 h^{-1}{\rm kpc}) + 0.39$. We find that the galaxy-halo size ratio $r_{1/2}/ R_{\rm vir}$ decreases with increasing halo mass. At fixed halo mass, there is no significant dependence of galaxy-halo size ratio on the halo spin or concentration.
description: 10 pages, 8 figures, accepted for publication in MNRAS
การจัดการความขัดแย้งเชิงสมานฉันท์ภายใต้แนวคิดยุติธรรมชุมชน: กรณีศึกษาเครือข่ายยุติธรรมชุมชน อำเภอพนมสารคาม จังหวัดฉะเชิงเทรา
Creators: name: สิทธิโชค ลางคุลานนท์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Restorative Conflict
Management Justice
Community Justice

description: Journal of Politics and Governance, 10, 1, 52-73
A Versatile Adeno-Associated Virus Vector Producer Cell Line Method for Scalable Vector Production of Different Serotypes
Creators: name: Xiao, Xiao
name: Li, Juan
name: Yuan, Zhenhua
name: Qiao, Chunping
name: Hu, Peiqi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Application of adeno-associated virus (AAV) vector in large animal studies and clinical trials often requires high-titer and high-potency vectors. A number of currently used vector production methods, based on either transient transfection or helper virus infection of cell lines, have their advantages and limitations. We previously developed a 293-cell–based producer cell line method for high-titer and high-potency AAV2 vectors. Similar to several other methods, however, it requires multiple cloning steps for the vector and packaging plasmids and a two-step transfection and selection for stable cell lines. Here we report a simplified method with several key improvements and advantages: (1) a one-step cloning of AAV vector cassette into the serotype-specific packaging plasmid; (2) a single plasmid transfection and selection for stable AAV vector producer cell lines; (3) high vector yields of different serotypes, e.g., AAV2, 8, and 9, upon infection with an E1A/E1B-deleted helper adenovirus; (4) efficient packaging of both single-stranded and double-stranded (self-complementary) AAV vectors; and (5) efficient packaging of large AAV cassettes such as a mini-dystrophin vector (5.0 kb). All cell lines were stable with growth rates identical to the parental 293 cells. The vector yields were consistent among serotypes, with 5 × 1013 to 8 × 1013 vector genome particles per Nunc cell factory (equivalent to 40 15-cm plates). The vectors showed high potency for in vitro and in vivo transduction. In conclusion, the simple and versatile AAV producer cell line method can be useful for large scale AAV vector production in preclinical and clinical studies.
Supplementary document for Rapid Scan White Light Pump-Probe Spectroscopy with 100 kHz Shot-to-Shot Detection - 6454486.pdf
Creators: name: BHAT, VIVEK
name: Thomas, Asha
name: Bhattacharyya, Atandrita
name: Tiwari, Vivek
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supporting Information
Preperiodic portraits for unicritical polynomials
Creators: name: Doyle, John R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Let $K$ be an algebraically closed field of characteristic zero, and for $c \in K$ and an integer $d \ge 2$, define $f_{d,c}(z) := z^d + c \in K[z]$. We consider the following question: If we fix $x \in K$ and integers $M \ge 0$, $N \ge 1$, and $d \ge 2$, does there exist $c \in K$ such that, under iteration by $f_{d,c}$, the point $x$ enters into an $N$-cycle after precisely $M$ steps? We conclude that the answer is generally affirmative, and we explicitly give all counterexamples. When $d = 2$, this answers a question posed by Ghioca, Nguyen, and Tucker.
description: Updated references; fixed minor error in Lemma 3.6
Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy
Creators: name: Bish, Lawrence T.
name: Morine, Kevin J.
name: Sleeper, Meg M.
name: Forbes, Sean C.
name: Singletary, Gretchen E.
name: Bogan, Janet
name: Walter, Glenn A.
name: Vandenborne, Krista
name: Sweeney, H. Lee
name: Trafny, Dennis
name: Kornegay, Joe N.
name: Pham, Jennifer
name: Reynolds, Caryn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Duchenne muscular dystrophy (DMD) is a lethal, X-linked recessive disease affecting 1 in 3,500 newborn boys for which there is no effective treatment or cure. One novel strategy that has therapeutic potential for DMD is inhibition of myostatin, a negative regulator of skeletal muscle mass that may also promote fibrosis. Therefore, our goal in this study was to evaluate systemic myostatin inhibition in the golden retriever model of DMD (GRMD). GRMD canines underwent liver-directed gene transfer of a self-complementary adeno-associated virus type 8 vector designed to express a secreted dominant-negative myostatin peptide (n=4) and were compared with age-matched, untreated GRMD controls (n=3). Dogs were followed with serial magnetic resonance imaging (MRI) for 13 months to assess cross-sectional area and volume of skeletal muscle, then euthanized so that tissue could be harvested for morphological and histological analysis. We found that systemic myostatin inhibition resulted in increased muscle mass in GRMD dogs as assessed by MRI and confirmed at tissue harvest. We also found that hypertrophy of type IIA fibers was largely responsible for the increased muscle mass and that reductions in serum creatine kinase and muscle fibrosis were associated with long-term myostatin inhibition in GRMD. This is the first report describing the effects of long-term, systemic myostatin inhibition in a large-animal model of DMD, and we believe that the simple and effective nature of our liver-directed gene-transfer strategy makes it an ideal candidate for evaluation as a novel therapeutic approach for DMD patients.
SOCIAL MEDIA ADVERTISING AND ITS INFLUENCE ON THE BUYING BEHAVIOR OF NIGERIAN UNIVERSITY STUDENTS
Creators: name: Dr. Ifeanyi Chukwuemeka, Okafor
Publisher: name: keith journal
Year: 2025
Subjects: Social Media, Facebook, Twitter, Instagram, YouTube, Buying Behaviour

description: The study was aimed at analysing the impact of social media advertisement on consumer buying behaviour. The survey research was used in this study to sample the opinion of respondents. This method involved random selection of respondent who were administered with questionnaires. The target population of the study comprised of students of selected departments in Chukwuemeka Odumegwu Ojukwu University. The questionnaire administered was one hundred and ten (110) copies and one hundred copies retrieved which constitute the sample size. The descriptive and analytical approach was adopted using Chi-square to test and analyze the hypotheses earlier stated. The findings revealed that there is a significant influence of social media advertising on consumers buying behaviour of Oral B and MyMy toothpaste products and that there is a significant relationship between social media advertising and consumers buying behaviour of Oral B and MyMy toothpaste products.  It was therefore concluded from the findings that social media reach allows consumers to create content in line with the firm’s products and services. This study concludes that social media mix allows the firm to use a combination of various communication channels in targeting different market segments and its main objective is to help the businesses in meeting up with the various marketing objectives. It was recommended that Oral B and MyMy toothpaste industries should embrace the use of social media reach in targeting different market segments to effectively influence consumer buying behaviour.
Rapid Transgene Expression in Multiple Precursor Cell Types of Adult Rat Subventricular Zone Mediated by Adeno-Associated Type 1 Vectors
Creators: name: McCarty, Douglas
name: Levivier, Marc
name: Samulski, R. Jude
name: De Witte, Olivier
name: Bockstael, Olivier
name: Tenenbaum, Liliane
name: Melas, Catherine
name: Pythoud, Catherine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The adult rat brain subventricular zone (SVZ) contains proliferative precursors that migrate to the olfactory bulb (OB) and differentiate into mature neurons. Recruitment of precursors constitutes a potential avenue for brain repair. We have investigated the kinetics and cellular specificity of transgene expression mediated by AAV2/1 vectors (i.e., adeno-associated virus type 2 pseudotyped with AAV1 capsid) in the SVZ. Self-complementary (sc) and single-stranded (ss) AAV2/1 vectors mediated efficient GFP expression, respectively, at 17 and 24 hr postinjection. Transgene expression was efficient in all the rapidly proliferating cells types, that is, Mash1+ precursors (30% of the GFP+ cells), Dlx2+ neuronal progenitors (55%), Olig2+ oligodendrocyte progenitors (35%), and doublecortin-positive (Dcx+) migrating cells (40%), but not in the slowly proliferating glial fibrillary acidic protein-positive (GFAP+) neural stem cell pool (5%). Because cell cycle arrest by wild-type and recombinant AAV has been described in primary cultures, we examined SVZ proliferative activity after vector injection. Indeed, cell proliferation was reduced immediately after vector injection but was normal after 1 month. In contrast, migration and differentiation of GFP+ precursors were unaltered. Indeed, the proportion of Dcx+ cells was similar in the injected and contralateral hemispheres. Furthermore, 1 month after vector injection into the SVZ, GFP+ cells, found, as expected, in the OB granular cell layer, were mature GABAergic neurons. In conclusion, the rapid and efficient transgene expression in SVZ neural precursors mediated by scAAV2/1 vectors underlines their potential usefulness for brain repair via recruitment of immature cells. The observed transient precursor proliferation inhibition, not affecting their migration and differentiation, will likely not compromise this strategy.
Flux trajectory analysis of Airy-type beams
Creators: name: Sanz, A. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Airy beams are solutions to the paraxial Helmholtz equation known for exhibiting shape invariance along their self-accelerated propagation in free space. These two properties are associated with the fact that they are not square integrable, that is, they carry infinite energy. To circumvent this drawback, families of so-called finite-energy Airy-type beams have been proposed in the literature and, in some cases, also implemented in the laboratory. Here an analysis of the propagation of this type of structured light beams is presented from a flux trajectory perspective with the purpose to better understand the mechanisms that make infinite and finite energy beams to exhibit different behaviors. As it is shown, while the foremost part of the beam can be clearly and unambiguously associated with the well-known accelerating term, the rear part of the beam corresponds to a nearly homogeneous distribution of flow trajectories, particularly for large propagation distances. This is shown to be related with an effective transfer of trajectories between adjacent lobes (gradually, from the fore part of the beam to its rear part), which leads to smearing out the transverse flow along the rear part of the beam. This is sharp contrast with the situation found in ideal Airy beams, where trajectories belonging to a given lobe of the intensity distribution remain the same all along the propagation. The analysis is supplemented with an also trajectory-based description of Young's experiment performed with finite-energy Airy beams in order to provide a dynamical understanding of the autofocusing phenomenon observed with circular Airy beams.
description: 10 pages, 3 figures
An upper limit on the ratio between the Extreme Ultraviolet and the bolometric luminosities of stars hosting habitable planets
Creators: name: Sengupta, Sujan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A large number of terrestrial planets in the classical habitable zone of stars of different spectral types has already been discovered and many are expected to be discovered in near future. However, owing to the lack of knowledge on the atmospheric properties, the ambient environment of such planets are unknown. It is known that sufficient amount of Extreme Ultraviolet (EUV) radiation from the star can drive hydrodynamic outflow of hydrogen that may drag heavier species from the atmosphere of the planet. If the rate of mass loss is sufficiently high then substantial amount of volatiles would escape causing the planet to become uninhabitable. Considering energy-limited hydrodynamical mass loss with an escape rate that causes oxygen to escape alongwith hydrogen, I present an upper limit for the ratio between the EUV and the bolometric luminosities of stars which constrains the habitability of planets around them. Application of the limit to planet-hosting stars with known EUV luminosities implies that many M-type of stars should not have habitable planets around them.
description: 16 pages (LATEX) including two eps figures. Substantially revised version, accepted for publication by Journal of Astrophysics and Astronomy
Fulde-Ferrell Superfluids without Spin Imbalance in Driven Optical Lattices
Creators: name: Zheng, Zhen
name: Qu, Chunlei
name: Zou, Xubo
name: Zhang, Chuanwei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Spin-imbalanced ultracold Fermi gases have been widely studied recently as a platform for exploring the long-sought Fulde-Ferrell-Larkin-Ovchinnikov superfluid phases, but so far conclusive evidence has not been found. Here we propose to realize an Fulde-Ferrell (FF) superfluid without spin imbalance in a three-dimensional fermionic cold atom optical lattice, where $s$- and $p$-orbital bands of the lattice are coupled by another weak moving optical lattice. Such coupling leads to a spin-independent asymmetric Fermi surface, which, together with the $s$-wave scattering interaction between two spins, yields an FF type of superfluid pairing. Unlike traditional schemes, our proposal does not rely on the spin imbalance (or an equivalent Zeeman field) to induce the Fermi surface mismatch and provides a completely new route for realizing FF superfluids.
description: 6 pages, 4 figures
Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart
Creators: name: Li, Juan
name: Yuan, Zhenhua
name: Qiao, Chunping
name: Tang, Ruhang
name: Li, Jianbin
name: Xiao, Xiao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Site-directed mutations of tyrosine (Y) to phenylalanine (F) on the surface of adeno-associated viral (AAV) capsids have been reported as a simple method to greatly enhance gene transfer in vitro and in vivo. To determine whether the Y-to-F mutation could also enhance AAV8 and AAV9 gene transfer in skeletal muscle and heart to facilitate muscular dystrophy gene therapy, we investigated four capsid mutants of AAV8 (Y447F or Y733F) and AAV9 (Y446F or Y731F). The mutants and their wild-type control AAV8 and AAV9 capsids were used to package reporter genes (luciferase or β-galactosidase) resulting in similar vector yields. To evaluate gene delivery efficiencies, especially in muscle and heart, the vectors were compared side by side in a series of experiments in vivo in two different strains of mice, the outbred ICR and the inbred C57BL/6. Because AAV8 and AAV9 are among the most effective in systemic gene delivery, we first examined the mutant and wild-type vectors in neonatal mice by intraperitoneal injection, or in adult mice by intravenous injection. To our surprise, no statistically significant differences in transgene expression were observed between the mutant and wild-type vectors, regardless of the reporter genes, vector doses, and the ages and strains of mice used. In addition, quantitative analyses of vector DNA copy number in various tissues from mice treated with mutant and wild-type vectors also showed similar results. Finally, direct intramuscular injection of the above-described vectors with the luciferase gene into the hind limb muscles revealed the same levels of gene expression between mutant and wild-type vectors. Our results thus demonstrate that a single mutation of Y447F or Y733F on capsids of AAV8, and of Y446F or Y731F on AAV9, is insufficient to enhance gene delivery to the skeletal muscle and heart.
In-plane electronic anisotropy revealed by interlayer resistivity measurements on the iron-based superconductor parent compound CaFeAsF
Creators: name: Terashima, Taichi
name: Hirose, Hishiro T.
name: Matsushita, Yoshitaka
name: Uji, Shinya
name: Ikeda, Hiroaki
name: Fuseya, Yuki
name: Wang, Teng
name: Mu, Gang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Both cuprates and iron-based superconductors demonstrate nematicity, defined as the spontaneous breaking of rotational symmetry in electron systems. The nematic state can play a role in the high-transition-temperature superconductivity of these compounds. However, the microscopic mechanism responsible for the transport anisotropy in iron-based compounds remains debatable. Here, we investigate the electronic anisotropy of CaFeAsF by measuring its interlayer resistivity under magnetic fields with varying field directions. Counterintuitively, the interlayer resistivity was larger in the longitudinal configuration ($B \parallel I \parallel c$) than in the transverse one ($B \perp I \parallel c$). The interlayer resistivity exhibited a so-called coherence peak under in-plane fields and was highly anisotropic with respect to the in-plane field direction. At $T$ = 4 K and $B$ = 14 T, the magnetoresistance $Δρ/ρ_0$ was seven times larger in the $B \parallel b_o$ than in the $B \parallel a_o$ configuration. Our theoretical calculations of the conductivity based on the first-principles electronic band structure qualitatively reproduced the above observations but underestimated the magnitudes of the observed features. The proposed methodology can be a powerful tool for probing the nematic electronic state in various materials.
description: 25 pages, 5 figures
The cubic Dirac equation: Small initial data in $H^{\frac12}(\mathbb{R}^2)$
Creators: name: Bejenaru, Ioan
name: Herr, Sebastian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q41

description: Global well-posedness and scattering for the cubic Dirac equation with small initial data in the critical space $H^{\frac12}(\mathbb{R}^2)$ is established. The proof is based on a sharp endpoint Strichartz estimate for the Klein-Gordon equation in dimension $n=2$, which is captured by constructing an adapted systems of coordinate frames.
description: 58 pages. Notation, setup and general reductions are adopted from our work arXiv:1310.5280, where we address the same problem in the 3d case. The analysis is significantly different. v3: 56 pages, Correction of the definitions of the sets \Lambda_{k,\omega} and \Lambda_{k,\omega}^{j}
Quality Assessment of Carbon Indicator Tier 1
Creators: name: Dominique Laurent, Eric Ceschia
Publisher: name: Zenodo
Year: 2022
Subjects: Carbon, Indicator Carbon flux, quality assessment

description: The carbon indicator (annual CO2 flux) has been computed by NIVA pilot - UC1b The UC1b team has developed three tools to compute this indicator: the first one at parcel level is a stand alone tool the second one at pixel level is also a stand alone tool the third one at pixel level is embedded in the Iota2 software. The two first tools, available on NIVA’s Gitlab, allow the processing of one Sentinel-2 tile whereas the third one allows multiple Sentinel-2 tiles to be processed at once and has been tested on the entire French territory. The first version of this document aims to identify the sources of errors, to estimate their impact on the indicator and to propose potential improvements for the carbon indicator at parcel level. The second version of this document will include the results of a quality assessment conducted on carbon indicator at pixel level.
Integrable delay-difference and delay-differential analogues of the KdV, Boussinesq, and KP equations
Creators: name: Nakata, Kenta
Publisher: name: arXiv
Year: 2022
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Delay-difference and delay-differential analogues of the KdV and Boussinesq (BSQ) equations are presented. Each of them has the N-soliton solution and reduces to an already known soliton equation as the delay parameter approaches 0. In addition, a delay-differential analogue of the KP equation is proposed. We discuss its N-soliton solution and the limit as the delay parameter approaches 0. Finally, the relationship between the delay-differential analogues of the KdV, BSQ, and KP equations is clarified. Namely, reductions of the delay KP equation yield the delay KdV and delay BSQ equations.
description: 21 pages, 1 figure
The effects of network structure, competition and memory time on social spreading phenomena
Creators: name: Gleeson, James P.
name: O'Sullivan, Kevin P.
name: Baños, Raquel A.
name: Moreno, Yamir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Online social media have greatly affected the way in which we communicate with each other. However, little is known about what are the fundamental mechanisms driving dynamical information flow in online social systems. Here, we introduce a generative model for online sharing behavior that is analytically tractable and which can reproduce several characteristics of empirical micro-blogging data on hashtag usage, such as (time-dependent) heavy-tailed distributions of meme popularity. The presented framework constitutes a null model for social spreading phenomena which, in contrast to purely empirical studies or simulation-based models, clearly distinguishes the roles of two distinct factors affecting meme popularity: the memory time of users and the connectivity structure of the social network.
description: This revised version accepted for publication in Physical Review X; note title has changed from the original "Determinants of Meme Popularity"
An Emerging Adeno-Associated Viral Vector Pipeline for Cardiac Gene Therapy
Creators: name: Asokan, Aravind
name: Samulski, R. Jude
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The naturally occurring adeno-associated virus (AAV) isolates display diverse tissue tropisms in different hosts. Robust cardiac transduction in particular has been reported for certain AAV strains. Successful applications of these AAV strains in preclinical and clinical settings with a focus on treating cardiovascular disease continue to be reported. At the same time, these studies have highlighted challenges such as cross-species variability in AAV tropism, transduction efficiency, and immunity. Continued progress in our understanding of AAV capsid structure and biology has provided the rationale for designing improved vectors that can possibly address these concerns. The current report provides an overview of cardiotropic AAV, existing gaps in our knowledge, and newly engineered AAV strains that are viable candidates for the cardiac gene therapy clinic.
VRContour: Bringing Contour Delineations of Medical Structures Into Virtual Reality
Creators: name: Chen, Chen
name: Yarmand, Matin
name: Singh, Varun
name: Sherer, Michael V.
name: Murphy, James D.
name: Zhang, Yang
name: Weibel, Nadir
Publisher: name: arXiv
Year: 2022
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Contouring is an indispensable step in Radiotherapy (RT) treatment planning. However, today's contouring software is constrained to only work with a 2D display, which is less intuitive and requires high task loads. Virtual Reality (VR) has shown great potential in various specialties of healthcare and health sciences education due to the unique advantages of intuitive and natural interactions in immersive spaces. VR-based radiation oncology integration has also been advocated as a target healthcare application, allowing providers to directly interact with 3D medical structures. We present VRContour and investigate how to effectively bring contouring for radiation oncology into VR. Through an autobiographical iterative design, we defined three design spaces focused on contouring in VR with the support of a tracked tablet and VR stylus, and investigating dimensionality for information consumption and input (either 2D or 2D + 3D). Through a within-subject study (n = 8), we found that visualizations of 3D medical structures significantly increase precision, and reduce mental load, frustration, as well as overall contouring effort. Participants also agreed with the benefits of using such metaphors for learning purposes.
description: C. Chen, M. Yarmand, V. Singh, M.V. Sherer, J.D. Murphy, Y. Zhang and N. Weibel, "VRContour: Bringing Contour Delineations of Medical Structures Into Virtual Reality", 2022 IEEE International Symposium on Mixed and Augmented Reality (ISMAR), 2022, pp. 1-10, doi: 10.1109/ISMAR55827.2022.00020
Active focal-plane coronagraphy with liquid-crystal spatial-light modulators: Broadband contrast performance in the visible
Creators: name: Kuhn, J. G.
name: Patapis, P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The technological progress in spatial-light modulators (SLM) technology has made it possible to use those devices as programmable active focal-plane phase coronagraphic masks, opening the door to novel versatile and adaptive high-contrast imaging observation strategies. However, the scalar nature of the SLM-induced phase response is a potential hurdle when applying the approach to wideband light, as is typical in astronomical imaging. For the first time, we present laboratory results with broadband light (up to ~12pc bandwidth) for two commercially-available SLM devices used as active focal-plane phase masks in the visible regime (640 nm). It is shown that under ideal or realistic telescope aperture conditions, the contrast performance is negligibly affected in this bandwidth regime, reaching sufficient level for ground-based high-contrast imaging, which is typically dominated by atmospheric residuals.
description: 15 pages, 5 figures
The Effect of Auditory and Visual Information on Choice
Creators: name: Mariadassou, Shwetha
name: Bechler, Christopher
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: decision-making
subject: judgment
subject: modality

description: We explore the effect of recommendation modality on recommendation adherence. Results from five experiments run on various online platforms (N = 6,103 adults from TurkPrime and Prolific) show that people are more likely to adhere to recommendations that they hear (auditory) than recommendations that they read (visual). This effect persists regardless of whether the auditory recommendation is spoken by a human voice or an automated voice and holds for hypothetical and consequential choices. We show that the effect is in part driven by the relative need for closure—manifested in a sense of urgency—that is evoked by the ephemerality of auditory messages. This work suggests that differences in the physical properties of auditory and visual modalities can lead to meaningful psychological and behavioral consequences.
Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical
Creators: name: Tisch, Roland
name: Hirsch, Matt
name: Johnson, Mark C.
name: Weinberg, Marc S.
name: He, Yi
name: Samulski, R. Jude
name: Li, Chengwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Adeno-associated viral (AAV) vectors 2 and 8 have been used in clinical trials for patients with hemophilia, and data suggest that the capsid-specific CD8+ T cell response has had a negative impact on therapeutic success. To date the pattern of capsid cross-presentation from AAV2 and AAV8 transduction in vivo has not been elucidated. Previously, we have demonstrated that an engineered AAV2 virus carrying the immune-dominant SIINFEKL peptide in the capsid backbone was indistinguishable from wild type with respect to titer, tropism, and the ability to induce capsid-specific CD8+ T cell responses in vivo. In this study, we used the same strategy to engineer an AAV8 vector and demonstrated that antigen from SIINFEKL peptide-integrated AAV8 capsid was effectively presented via either plasmid transfection or AAV8 transduction in vitro. The tissue tropism and transgene expression kinetics of the engineered AAV8 vector in vivo were identical to that of wild-type AAV8. Animal studies show that capsid antigen presentation from AAV transduction was dose dependent, and more importantly, the proliferation of capsid-specific CD8+ T cells had similar kinetics (detectable before 30 days and undetectable after 40 days) for both AAV2 and AAV8 vectors. Elucidation of the kinetics of capsid antigen presentation from AAV transduction by various serotypes provides new insight into the potential impact CD8+ T cells can have during clinical trials and may help with rational design of effective strategies to prevent capsid-specific CD8+ T cell-mediated elimination of AAV-transduced target cells.
Surgical management in preeclampsia. Literature from a high specialty medical unit in Mexico City
Creators: name: Juan Gustavo Vázquez Rodríguez M.D.
name: Valentín Tovar Galván M.D.
Publisher: name: Zenodo
Year: 2023

description: The intervention of the obstetrician-gynecologist and the surgeon in the management of patients with preeclampsia is not limited to pregnancy termination through vaginal delivery or cesarean section. It also includes the control of obstetric hemorrhage from the placental insertion site, due to uterine complications or accidental injury to blood vessels, urinary structures and intestines. The participation of the general surgeon, vascular surgeon, urological surgeon or gastroenterological surgeon in the management of extremely serious cases can make a difference in the evolution and outcome of patients.
Coordination with medical specialists in critical medicine is necessary at all times to achieve successful results.  The multidisciplinary team must share the basic knowledge of the subject, the advances in surgical technique, advanced intensive care and the experience acquired with each case. This review offers an overview of the surgical management of patients with preeclampsia. Only publications from the years 2015 to September 2023 of the authors who work in the host hospital have been included. The intention is to share the criteria and local evidence with the international community.
 
Keywords: Preeclampsia; Cesarean section; Ruptured liver hematoma; Obstetric hemorrhage; High risk pregnancy; Intensive care in obstetrics.
Visualizing the elongated vortices in $γ$-Ga nanostrips
Creators: name: Zhang, Hui-Min
name: Li, Zi-Xiang
name: Peng, Jun-Ping
name: Song, Can-Li
name: Guan, Jia-Qi
name: Li, Zhi
name: Wang, Lili
name: He, Ke
name: Ji, Shuai-Hua
name: Chen, Xi
name: Yao, Hong
name: Ma, Xu-Cun
name: Xue, Qi-Kun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the magnetic response of superconducting $γ$-Ga via low temperature scanning tunneling microscopy and spectroscopy. The magnetic vortex cores rely substantially on the Ga geometry, and exhibit an unexpectedly-large axial elongation with aspect ratio up to 40 in rectangular Ga nano-strips (width $l$ $
description: published in Phys. Rev. B as a Rapid Communication