title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð²Ð¸ÑÑÑÐ° Ð³ÑÐ¸Ð¿Ð¿Ð° A(H1N1)pdm09 Ð½Ð° ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ð¹ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð¾Ð² Ð»ÑÐ³ÐºÐ¸Ñ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ½ÑÑ ÐºÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Influence of influenza A(H1N1)pdm09 virus on the endothelium of blood vessels of the lungs of laboratory rats
Creators: name: ÐÐ°ÑÑÐ°ÑÐ¾Ð²Ð°, ÐÐ½Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð²Ð¸ÑÑÑ Ð³ÑÐ¸Ð¿Ð¿Ð° Ð
Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ· Ð³ÑÐ¸Ð¿Ð¿Ð°
Ð¸Ð½ÑÐµÐºÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÐµ ÑÐ¾ÑÑÐ´Ñ Ð»ÑÐ³ÐºÐ¸Ñ
ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ð¹
Ð³Ð¸ÑÑÐ¾Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ
Ð´Ð¸ÑÑÑÐ½ÐºÑÐ¸Ñ ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ
influenza A virus
influenza pathogenesis
infectious activity
pulmonary blood vessels
endothelium
histopathologic changes
endothelial dysfunction

description: Ð­Ð½Ð´Ð¾ÑÐµÐ»Ð¸Ð°Ð»ÑÐ½ÑÐµ ÐºÐ»ÐµÑÐºÐ¸ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð¾Ð² ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°ÑÑ ÑÐ¸Ð°Ð»Ð¾Ð²ÑÐµ ÐºÐ¸ÑÐ»Ð¾ÑÑ, Ñ ÐºÐ¾ÑÐ¾ÑÑÐ¼Ð¸ Ð¼Ð¾Ð¶ÐµÑ ÑÐ²ÑÐ·ÑÐ²Ð°ÑÑÑÑ Ð²Ð¸ÑÑÑ Ð³ÑÐ¸Ð¿Ð¿Ð° Ð, Ð¿Ð¾ÑÑÐ¾Ð¼Ñ ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ð¹ ÑÐ²Ð»ÑÐµÑÑÑ Ð¼Ð¸ÑÐµÐ½ÑÑ Ð´Ð»Ñ Ð²Ð¸ÑÑÑÐ° Ð¸ Ð¸Ð³ÑÐ°ÐµÑ Ð²Ð°Ð¶Ð½ÑÑ ÑÐ¾Ð»Ñ Ð² Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ. ÐÐµÑÐ¼Ð¾ÑÑÑ Ð½Ð° ÑÑÐ¾, ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð¾Ð² Ð´Ð¾ Ð¸ Ð¿Ð¾ÑÐ»Ðµ ÑÐ»Ð¸Ð¼Ð¸Ð½Ð°ÑÐ¸Ð¸ Ð²Ð¸ÑÑÑÐ° Ð³ÑÐ¸Ð¿Ð¿Ð° Ð¾ÑÑÐ°ÐµÑÑÑ Ð¼Ð°Ð»Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð½ÑÐ¼. ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¸ Ð²ÑÑÐ°Ð¶ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¼Ð¾ÑÑÐ¾ÑÑÑÑÐºÑÑÑÐ½ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ñ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð¾Ð² Ð»ÑÐ³ÐºÐ¸Ñ ÐºÑÑÑ ÑÑÐ¾ÐºÐ° Wistar, Ð¸Ð½ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð²Ð¸ÑÑÑÐ¾Ð¼ Ð³ÑÐ¸Ð¿Ð¿Ð° A(H1N1)pdm09. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð³Ð¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð²Ð¸ÑÑÑ Ð³ÑÐ¸Ð¿Ð¿Ð° Ð Ð²ÑÐ·ÑÐ²Ð°ÐµÑ Ð¼Ð¾ÑÑÐ¾ÑÑÑÑÐºÑÑÑÐ½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð¹ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð²ÑÑÐ°Ð¶ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð² ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð°Ñ Ð»ÑÐ³ÐºÐ¸Ñ ÐºÑÑÑ Ð½Ð° Ð¿ÑÐ¾ÑÑÐ¶ÐµÐ½Ð¸Ð¸ 30-ÑÐ¸ Ð´Ð½ÐµÐ¹ Ð¿Ð¾ÑÐ»Ðµ Ð¸Ð½ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ, ÑÑÐ¾ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÐµÑ Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð´Ð¸ÑÑÑÐ½ÐºÑÐ¸Ð¸. Ð¡Ð»ÐµÐ´ÑÐµÑ Ð¾ÑÐ¼ÐµÑÐ¸ÑÑ, ÑÑÐ¾ Ð¿Ð¾ Ð´Ð°Ð½Ð½ÑÐ¼ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸ Ð´ÐµÑÐµÐºÑÐ¸Ð¸ Ð½ÑÐºÐ»ÐµÐ¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð° Ð²Ð¸ÑÑÑÐ° Ð³ÑÐ¸Ð¿Ð¿Ð° Ð, Ð¿Ð¾ÑÐ»Ðµ 7-Ð³Ð¾ Ð´Ð½Ñ Ð² ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð°Ñ Ð»ÑÐ³ÐºÐ¸Ñ Ð²Ð¸ÑÑÑ Ð½Ðµ Ð¾Ð±Ð½Ð°ÑÑÐ¶Ð¸Ð²Ð°Ð»ÑÑ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð·Ð°Ð¿Ð¾Ð»Ð½ÑÑÑ Ð¿ÑÐ¾Ð±ÐµÐ»Ñ Ð² Ð·Ð½Ð°Ð½Ð¸ÑÑ Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ð¸ Ð²Ð¸ÑÑÑÐ° Ð³ÑÐ¸Ð¿Ð¿Ð° Ð Ð½Ð° ÑÐ½Ð´Ð¾ÑÐµÐ»Ð¸Ð¹ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÑ ÑÐ¾ÑÑÐ´Ð°Ñ Ð»ÑÐ³ÐºÐ¸Ñ Ð¸ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½Ð¾Ð²ÑÑ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð² Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð³ÑÐ¸Ð¿Ð¿Ð° Ð¸ Ð²ÑÐ·Ð²Ð°Ð½Ð½ÑÑ Ð¸Ð¼ Ð¾ÑÐ»Ð¾Ð¶Ð½ÐµÐ½Ð¸Ð¹.
description: The endothelial cells of blood vessels are able to express sialic acids to which the influenza A virus can bind, so the endothelium is a target for the virus and plays an important role in pathogenesis. Despite this, the state of blood vessel endothelium before and after Influenza virus elimination remains poorly understood. The present work was devoted to the investigation of the duration and severity of morphostructural changes in the endothelium of blood vessels of the lungs of Wistar stock rats infected with influenza A(H1N1)pdm09 virus. Using histologic study it was shown that influenza A virus causes morphostructural changes of varying degrees of severity in rat lung blood vessels during 30 days after infection, indicating the development of endothelial dysfunction. It should be noted that according to infectivity and nucleoprotein detection of influenza A virus, no virus was detected in the blood vessels of the lungs after day 7. Thus, the obtained data fill the gaps in knowledge about the influence of influenza A virus on the endothelium of blood vessels of the lungs and can be used to develop new therapeutic approaches for the treatment of influenza and complications caused by it.