cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of type 1 diabetes-related proteins
Creators: name: Powell, Karen L
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Chemistry, Biochemistry.

description: Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease, whereby the insulin-secreting beta-cells of the pancreas are targeted and destroyed by the patient's immune system. Although genetic susceptibility is required for the onset of this autoimmune disorder, environmental factors, including infectious agents and diet, also play an important but poorly understood role. Recently, WP5212 was identified as the first candidate diabetes-related wheat protein. To identify candidate molecular mimics of this wheat protein in target tissues, a novel approach was developed. Antibodies raised against two short peptides of this dietary antigen cross-react with self proteins: an exocrine pancreatic 33 kDa protein and a 28 kDa protein in the islets, spleen and mesenteric lymph nodes. In order to identify additional putative targets, a broad spectrum polyclonal serum was generated. In addition, a second antigenic wheat protein was identified by screening a wheat cDNA expression library with antibodies from a highly wheat-sensitive patient with both T1D and celiac disease. Further characterization of candidate molecular targets and antigenic wheat proteins may reveal novel pathways related to environmentally-induced T1D.
Worlding the intangibility of resilience : the case of rice farmers in a water-stressed region of the Philippines
Creators: name: Shah, Sameer Hemant
name: Angeles, Leonora C.
name: Harris, Leila
Publisher: name: The University of British Columbia
Year: 2019

description: Agricultural livelihoods are resilient when capable of enduring and overcoming socio-environmental stressors. The “Sustainable Livelihoods Approach”, popularized in development programs frequently targets farmer capacities to cope with and recover from loss and damage by i) enhancing tangible capitals (e.g. ecological, financial) and / or by ii) reducing socio-institutional constraints on entitlements and opportunities to access those capitals. While this two-pronged approach can reduce damage to production or expand the range of livelihood activities available to farmers, it often positions tangible capitals themselves as the central and objective means for building resilience. The recent “social turn” is a call to theorize resilience’s intangible and non-material dimensions (e.g. subjective, emotive, and relational forms) as emergent from specific local social-cultural-ecological contexts. Drawing on in-depth field research with rice-farmers in a region of the Philippines experiencing water-related stressors, we analyzed several situated “intangible” narrations of resilience, with a focus on emotive and affective indicators. Farmers narrated their courage to get back up following loss and damage as well as their optimism, faith, and hope for brighter futures in farming. These emotions flowed from their affective relationships with the cosmos (naturalizing life’s hardships as cyclical), themselves (strong belief in their own capabilities to persist in times of hardship), and the Divine (faith in God’s power to protect hard-working families). Our results contribute to the “social turn” in resilience literature in two ways. First, we highlight affect and emotion as indicators of farm livelihood resilience. Second, we suggest narrations of resilience are constituted through farmers’ particular “worldings”, or constructions of reality where knowledge, belief systems, and relations, are lived and enacted on an everyday basis. Situating oneself in local contexts can illuminate sources of intangible resilience otherwise hidden from top-down approaches, while engaging “worldings” can help render these intangible sources intelligible within their contexts.
IMPACTS OF VIDEO GAMING ON AGGRESSION AND COGNITIVE ABILITY OF PAKISTANIS VIDEO GAMERS
Creators: name: Kanwal Shahbaz, Annum Khan
Publisher: name: TuEngr Group
Year: 2019
Subjects: Video game player
Cognitive ability Buss-Perry Aggression Questionnaire
Emotional disturbances
Female-video-gamers
Male-video-gamers.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 14, 10A14I: 1-10
Les problématiques rencontrées par les réfugiées dans les camps: Étude de l'impact de la prédominance du féminisme libéral dans les programmes et l'élaboration des politiques du Haut Commissariat des Nations Unies pour les réfugiés
Creators: name: Tanguay, Annie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Political Science, General.

description: La problématique principalement observée lors de cette thèse provient du fait que l'angle libéral a une conception restreinte des notions de réfugiés, de femmes, de "genre" et de refugiées. Qui plus est, les lacunes du biais libéral, dorénavant fortement dénoncées, sont masquées par l'utilisation du féminisme libéral, au sein du HCR. Ce faisant, le HCR ne remet pas en cause les fondements des principes libéraux, mais ne "retouche" que la forme. La prédominance de la lecture des féministes libérales s'articule, notamment, dans les orientations et les préoccupations du HCR à l'égard des femmes réfugiées dans les camps. Les études des politiques et des programmes qu'a élaboré le HCR à l'égard des réfugiées mettent en relief le fait que l'Organisation voit principalement la résolution de problèmes de la réfugiée avec les lunettes des féministes libérales, qu'il n'arrive pas à comprendre le construit social dans lequel évoluent ces refugiées et donc, ne parvient aucunement à résoudre efficacement les problèmes rencontrés à l'intérieur des camps. Ainsi, les difficultés, pour le HCR, d'appréhender la refugiée proviennent non pas d'un manque de politiques et d'action envers ces dernières, mais plutôt du biais libéral qu'utilise l'Organisation et du fait que son effort va dans le sens du féminisme libéral. L'étude empirique de trois camps kenyans fait d'ailleurs état de la concrétisation des solutions, par le HCR, qui vont dans le sens du féminisme libéral.
TTIP: Regulierungszusammenarbeit auf Kosten der Umwelt?
Creators: name: Callies, Christian
name: Dross, Miriam
Publisher: name: My University
Year: 2016

description: Das geplante transatlantische Handels- und Investitionsabkommen TTIP (Transatlantic Trade and Investment Partnership) zwischen der EU und den USA steht in der Kritik. Diese richtet sich auch gegen die geplante Zusammenarbeit in Regulierungsfragen, weil mit ihr die Befürchtung verbunden wird, dass das Schutzniveau im Umwelt- und Gesundheitsbereich sinken könnte. Der nachfolgende Beitrag stellt zunächst die regulatorische Kooperation in ihren Grundzügen dar und ordnet sie dann im Hinblick auf mögliche Auswirkungen auf die Umwelt ein. Quelle: http://www.doev.de
Against the rules: A marine bacterium, Loktanella rosea, possesses a unique lipopolysaccharide
Creators: name: Ieranò, Teresa
name: Silipo, Alba
name: Nazarenko, Evgeny L.
name: Gorshkova, Raisa P.
name: Ivanova, Elena
name: Garozzo, Domenico
name: Sturiale, Luisa
name: Lanzetta, Rosa
name: Parrilli, Michelangelo
name: Molinaro, Antonio
Publisher: name: Swinburne
Year: 2024

description: Bacteria are an inimitable source of new glyco-structures potentially useful in medicinal and environmental chemistry. Lipopolysaccharides (LPS; endotoxins) are the major components of the outer membrane of Gram-negative bacteria; being exposed toward the external environment they can undergo structural changes and thus, they often possess peculiar chemical features that allow them to thrive in harsh chemical and physical environments. Marine bacteria have evolved and adapted over millions of years in order to succeed in different environments, finding a niche for their survival characterized by severe physical or chemical parameters. The present work focuses on the structural investigation of the LPS from Loktanella rosea, a marine Gram-negative bacterium. Through chemical analysis, 2D nuclear magnetic resonance and matrix-assisted laser desorption ionization mass spectrometry investigations, a unique LPS carbohydrate backbone has been defined. The lipid A skeleton consists of a trisaccharide backbone lacking the typical phosphate groups and is characterized by two β-glucosamines and an α-galacturonic acid. The core region is built up of three ulosonic acids, with two 3-deoxy-D-manno-oct-2-ulopyranosonic acid residues, one of which is carrying a neuraminic acid. This carbohydrate structure is an exceptional variation from the typical architectural skeleton of endotoxins which consequently implies a very different biosynthesis.
A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice
Creators: name: Schirm, Sibylle
name: Ahnert, Peter
name: Wienhold, Sandra
name: Mueller-Redetzky, Holger
name: Nouailles-Kursar, Geraldine
name: Loeffler, Markus
name: Witzenrath, Martin
name: Scholz, Markus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Pneumonia is considered to be one of the leading causes of death worldwide. The outcome depends on both, proper antibiotic treatment and the effectivity of the immune response of the host. However, due to the complexity of the immunologic cascade initiated during infection, the latter cannot be predicted easily. We construct a biomathematical model of the murine immune response during infection with pneumococcus aiming at predicting the outcome of antibiotic treatment. The model consists of a number of non-linear ordinary differential equations describing dynamics of pneumococcal population, the inflammatory cytokine IL-6, neutrophils and macrophages fighting the infection and destruction of alveolar tissue due to pneumococcus. Equations were derived by translating known biological mechanisms and assuming certain response kinetics. Antibiotic therapy is modelled by a transient depletion of bacteria. Unknown model parameters were determined by fitting the predictions of the model to data sets derived from mice experiments of pneumococcal lung infection with and without antibiotic treatment. Time series of pneumococcal population, debris, neutrophils, activated epithelial cells, macrophages, monocytes and IL-6 serum concentrations were available for this purpose. The antibiotics Ampicillin and Moxifloxacin were considered. Parameter fittings resulted in a good agreement of model and data for all experimental scenarios. Identifiability of parameters is also estimated. The model can be used to predict the performance of alternative schedules of antibiotic treatment. We conclude that we established a biomathematical model of pneumococcal lung infection in mice allowing predictions regarding the outcome of different schedules of antibiotic treatment. We aim at translating the model to the human situation in the near future.
La météorisation des grès des terrasses de Bug Creek, Territoires du Nord-Ouest, Canada.
Creators: name: Lamirande, Iannick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Physical Geography.

description: The purpose of this study is to determine the origin of the sediments that lie on the treads of the cryoplanation terraces of the Richardson Mountains in the Northwest Territories, Canada. A series of 15 bore holes were done on the treads of the terraces, at the bottom of which organic material was found and dated by radiocarbon method. Petrographic, granulometric, exoscopic and geochemical analyses were done on the sandstone of the Aklavik Formation of the Bug Creek Group, on the surface sediments and on the core sediments. The objectives of these analyses were to compare the petrology of the local sandstone to the sediments found on the treads of the terraces, to determine the granulometric distribution of the sediments, to determine the scarp's rate of weathering and the chronology of the events that took place. The results show that the sediments are produced by disintegration of the local sandstone of the Aklavik Formation. The weathering of the rock causes an increase in the intergranular porosity and fractures in the grains of quartz. The weathering of the sandstone releases sands, silts and clay. This material constitutes a potential source of loess in glacial times. The accumulation of sediments that lie currently on the treads of the terraces which are derived from the weathering of the sandstone, could have begun to accumulate about 5397 +/- 84 BP or even earlier at about 9420 +/- 90 BP. A weathering rate of the rock scarp was calculated at about 20 mm/1000 years and would seem to indicate that the terraces could have started to develop in the Tertiary period.
The Green Tea Catechin Epigallocatechin Gallate Ameliorates Graft-versus-Host Disease
Creators: name: Westphal, Sabine
name: McGeary, Aleixandria
name: Rudloff, Sandra
name: Wilke, Andrea
name: Penack, Olaf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is a standard treatment for leukemia and other hematologic malignancies. The major complication of allo-HSCT is graft-versus-host-disease (GVHD), a progressive inflammatory illness characterized by donor immune cells attacking the organs of the recipient. Current GVHD prevention and treatment strategies use immune suppressive drugs and/or anti-T cell reagents these can lead to increased risk of infections and tumor relapse. Recent research demonstrated that epigallocatechin gallate (EGCG), a component found in green tea leaves at a level of 25–35% at dry weight, may be useful in the inhibition of GVHD due to its immune modulatory, anti-oxidative and anti-angiogenic capacities. In murine allo-HSCT recipients treated with EGCG, we found significantly reduced GVHD scores, reduced target organ GVHD and improved survival. EGCG treated allo-HSCT recipients had significantly higher numbers of regulatory T cells in GVHD target organs and in the blood. Furthermore, EGCG treatment resulted in diminished oxidative stress indicated by significant changes of glutathione blood levels as well as glutathione peroxidase in the colon. In summary, our study provides novel evidence demonstrating that EGCG ameliorates lethal GVHD and reduces GVHD-related target organ damage. Possible mechanisms are increased regulatory T cell numbers and reduced oxidative stress.
Genetic Counseling for Alcohol Addiction : Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members
Creators: name: Kalb, Fayth Michelle
name: Vincent, Victoria
name: Herzog, Teresa
name: Austin, Jehannine
Publisher: name: The University of British Columbia
Year: 2018

description: Though addictions to substances including alcohol are highly heritable, there have been no studies regarding the possible applicability of genetic counseling to this set of conditions. Adults (≥18 years old) with a personal and/or family history of alcohol addiction were recruited to participate in an online survey-based study comprising 43 questions about beliefs/concern about recurrence risk and etiology of alcohol addiction and its impact on childbearing decisions, and perceptions of potential utility of genetic counseling for alcohol addiction. We applied primarily descriptive statistics, but also tested the hypotheses that perceiving genetic counseling to be useful would be associated with: 1) increasing importance attributed to genetics in the etiology of alcohol addiction, and 2) greater concern about recurrence of alcohol addiction (in self and/or children). Overall, the 113 participants recognized the multifactorial nature of alcohol addiction but reported a wide range of estimated recurrence risks for first-degree relatives. Overall, 62% perceived genetic counseling for alcohol addiction to be potentially beneficial. Participants were more likely to perceive a benefit from genetic counseling if they were concerned about recurrence for themselves (p = .021) or perceived genetics to be etiologically important in alcohol addiction (p = .024). Future studies are warranted to evaluate the outcomes of genetic counseling for addictions with respect to patient understanding, lifestyle modifications and psychological adaptation.
Wave and Wind Turbulence in the Upper Ocean
Creators: name: Fadaeiazar, Elmira
Publisher: name: Swinburne
Year: 2024

description: Waves on the ocean carry energy and one wave transfers energy to another. Wave on the ocean surface also dissipate energy to the surrounding atmosphere and contribute in the ocean and atmosphere energy budget and, thereby playing a role in long term climate change. Therefore, it is important to understand wave dynamics and the long-term effect. they have on the environment. The thesis includes detailed analysis of the dynamics of ocean waves and their effect on the surrounding environment.
Kanalabdichtungen - Auswirkungen auf die Reinigungsleistung der Kläranlagen und der Einfluss auf den örtlichen Wasserhaushalt
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: Kanalisation
subject: Kläranlage
subject: Abwasserkanalisation
subject: Abwasserleitungskorrosion
subject: Kanalabdichtung
subject: Kläranlagen
subject: Regenwasserbecken
subject: Wasserhaushalt
subject: Belastung des Grundwassers
subject: Leckage
subject: Wasser
subject: Water

description: Undichte Kanäle im Bereich der öffentlichen Abwasserentsorgung und der Grundstücksentwässerung können je nach örtlichen Gegebenheiten zu Problemen durch Infiltration von Grund-, Schichten- oder Sickerwasser führen. Im Mischsystem kann es zu vermehrten Mischwasserabschlägen und damit zur zusätzlichen Belastung der Gewässer kommen. Ein erhöhter Fremdwasseranteil wirkt sich zudem negativ auf die Kläranlagenleistung aus. Sanierungsmaßnahmen am Kanalnetz sind erforderlich, um öffentliche und private Abwasserleitungen
und -kanäle abzudichten und das Fremdwasseraufkommen deutlich zu reduzieren. Im Forschungsvorhaben wurden Nutzen, Aufwand und Risiken flächenhafter Kanalabdichtung an undichten Abwasserleitungen und -kanälen anhand von Praxisbeispielen untersucht, umfassend
dargestellt und Anforderungen für die Kanalsanierung erarbeitet.
Quelle: www.umweltbundesamt.de

description: Undichte Kanäle im Bereich der öffentlichen Abwasserentsorgung und der Grundstücksentwässerung können je nach örtlichen Gegebenheiten zu Problemen durch Infiltration von Grund-, Schichten- oder Sickerwasser führen. Im Mischsystem kann es zu vermehrten Mischwasserabschlägen und damit zur zusätzlichen Belastung der Gewässer kommen. Ein erhöhter Fremdwasseranteil wirkt sich zudem negativ auf die Kläranlagenleistung aus. Sanierungsmaßnahmen am Kanalnetz sind erforderlich, um öffentliche und private Abwasserleitungenund -kanäle abzudichten und das Fremdwasseraufkommen deutlich zu reduzieren. Im Forschungsvorhaben wurden Nutzen, Aufwand und Risiken flächenhafter Kanalabdichtung an undichten Abwasserleitungen und -kanälen anhand von Praxisbeispielen untersucht, umfassenddargestellt und Anforderungen für die Kanalsanierung erarbeitet.
title: Philosophizing Boardwalk empire
title: Revising and re-animating women's issues in relation to prohibition of the 1920s and modern America
titleType: Subtitle
Creators: name: Avalon, Brittani Renee
Publisher: name: Washington State University
Year: 2014
Subjects: Prohibition--United States
Prohibition
Feminism and mass media
Boardwalk empire (Television program)
United States

description: Television resonates with modern viewers for more than just entertainment reasons. People today have moved beyond sitcoms, and look to programs like Boardwalk Empire to contemplate and explore their own real-life concerns. In the case of Boardwalk Empire, discussions of issues like restraint, prohibition and excess, as well as the role of women in health care, in public and political forums, and in personal and familial relationships, are discussed through the weekly narrative. This paper looks at the question "What are the concerns in current culture that both echo and reanimate the concerns of 1920s America through the television series Boardwalk Empire?", and examines the ways in which Boardwalk Empire uses the character Margaret to revise historical ideas through creating an overlay of modern cinematic and moral perspectives in order to revisit women's issues and prohibition of 1920s America.
Natural Medicinal Drug Delivery from 3D Printed Scaffold and Surface Modified TI6AL4v Implants for Chemoprevention, Osteogenesis and Anti-inflammation for Bone Tissue Engineering Application
Creators: name: Sarkar, Naboneeta
Publisher: name: Washington State University
Year: 2019
Subjects: Three-dimensional printing -- Therapeutic use

description: The objective of this research is to understand the role of natural medicinal compounds (NMCs) in bone tissue engineering application by modifying their release kinetics from the porous 3DP scaffold, evaluating their in vitro osteoblast (hFOB) proliferating and osteosarcoma (MG-63) preventing efficacy, and investigating their effect on osteogenesis, anti-inflammation and wound healing in rat distal femur model.Curcumin, although exhibit excellent antioxidant, anti-inflammatory, anticancer and osteogenic activities, suffers from extremely poor bioavailability. To enhance its bioavailability and to provide higher release, poly-(I? -caprolactone) (PCL), poly-ethylene-glycol (PEG) and poly-lactide-co-glycolide (PLGA) is used as the polymeric system to enable the continuous release of curcumin from the hydroxyapatite matrix for 22 days. The presence of curcumin in interconnected 3DP TCP scaffolds results in enhanced bone formation after 6 weeks in rat distal femur model. Complete mineralized bone formation increases from 29.6% to 44.9% in curcumin-coated scaffolds compared to control. In a follow-up study, we have further improved the bioavailability of curcumin by encapsulating it in a liposome, followed by the incorporation onto 3DP TCP scaffolds with designed porosity. Interestingly, liposomal curcumin released from the 3DP scaffold shows significant cytotoxicity towards MG-63 cells, while it promoted hFOB cell viability and proliferation. Presence of genistein, a soy-isoflavone shows a 90% reduction in vitro MG-63 cell viability and proliferation after 11 days, while, daidzein, another primary isoflavone, promotes in vitro hFOB cellular activities in both static and dynamic cell culture. In vitro H&E staining confirms controlled co-delivery of soy-isoflavones from the 3DP scaffold significantly reduces inflammatory cell recruitment at the surgery site after 24 hours of implantation in a rat distal femur model.Another more stable form of calcium phosphate, hydroxyapatite (HA) is utilized as a coating on metallic orthopedic implants for load-bearing applications. Coated implants are loaded with curcumin and vitamin K2, which enhances in vitro hFOB cell activities, while lowers in vitro MG-63 cell proliferation after 3, 7 and 11 days. Modified Masson Goldner staining of the tissue-implant section shows an improved contact between tissue and implant in dual drug-loaded HA-coated Ti implants compared to control implants in in vitro rat distal femur model.
Fragrance allergens in household detergents
Creators: name: Olsson, Oliver
name: Wieck, Stefanie
name: Kümmerer, Klaus
Publisher: name: My University
Year: 2018

description: Consumers are confronted with a large number of fragrance allergens from various sources. Until now, the discussion of exposure sources has mainly addressed cosmetic products and neglected other scented products in households. For the first time, fragrance allergens were evaluated in a complete set of detergents in households. In 131 households, we investigated the prevalence of detergents and searched their lists of ingredients for 26 fragrance allergens liable to be indicated on products according to the European Detergents Regulations. On the ingredient lists of 1447 products, these 26 fragrance substances were named almost 2000 times, most often limonene, linalool and hexyl cinnamal. Benzyl salicylate was used frequently in all-purpose cleaners. Linalool and limonene, hexyl cinnamal and butylphenyl methylpropional and citronellol and linalool co-occurred most often together in products. Fragrance allergens co-occurring together most frequently within households were eugenol, coumarin and cinnamyl alcohol. The study shows that detergents could play a relevant role for the exposure of consumers towards fragrance allergens and that they should not be underestimated as an exposure source during the exposure assessment. © 2018 Elsevier Inc. All rights reserved.
Lessons in nation-building: reframing a fractured nation. A Study of Nation-building in Fiji
Creators: name: Mudaliar, Christopher
Publisher: name: Swinburne
Year: 2024

description: This thesis explores historic and contemporary conceptions of Fijian nationhood in order to evaluate recent nation-building attempts. It does this by examining the dissemination of competing nationhood discourses throughout Fijian history in order to compare these against contemporary developments. This thesis provides a theoretical framework alongside quantitative data from which to judge Fiji's efforts at resolving historic ethnic conflict. In doing so it shines light on theoretical and practical arguments surrounding the resolution of ethnic
conflict within society.
title: Umweltschädliche Subventionen in Deutschland
title: Umweltschädliche Subventionen in Deutschland
titleType: AlternativeTitle
Creators: name: Burger, Andreas
name: Köder, Lea
Publisher: name: Umweltbundesamt
Year: 2017
Subjects: subject: Umweltschädliche Subvention
subject: Umweltbelastung
subject: Klimabeeinflussung
subject: Subventionsabbau
subject: Bundesrepublik Deutschland
subject: Klimaschädliche Subvention
subject: Abbau umweltschädlicher Subventionen
subject: Umweltschädliche Subventionen
subject: Klima | Energie
subject: Wirtschaft | Konsum
subject: Nachhaltigkeit | Strategien | Internationales

description: Die umweltschädlichen Subventionen in Deutschland sind weiterhin viel zu hoch und liegen 2012 bei nunmehr 57 Milliarden Euro. Dies zeigt eine aktuelle Studie des Umweltbundesamts (UBA ). Über 90 Prozent dieser Subventionen belasten das Klima - und konterkarieren so die deutsche Umsetzung des Pariser Klimaschutzabkommens. Allein drei Milliarden Euro kostet es die Bürgerinnen und Bürger, weil der Staat das produzierende Gewerbe sowie die Land- und Forstwirtschaft bei der Strom- und Energiesteuer entlastet. Unternehmen, aber auch Verbraucherinnen und Verbraucher, haben so weniger Anreiz, Energie zu sparen. Quelle: https://www.umweltbundesamt.de
description: Die umweltschädlichen Subventionen in Deutschland sind weiterhin viel zu hoch und liegen 2012 bei nunmehr 57 Milliarden Euro. Dies zeigt eine aktuelle Studie des Umweltbundesamts (⁠UBA⁠). Über 90 Prozent dieser Subventionen belasten das ⁠Klima⁠ – und konterkarieren so die deutsche Umsetzung des Pariser Klimaschutzabkommens. Allein drei Milliarden Euro kostet es die Bürgerinnen und Bürger, weil der Staat das produzierende Gewerbe sowie die Land- und Forstwirtschaft bei der Strom- und Energiesteuer entlastet. Unternehmen, aber auch Verbraucherinnen und Verbraucher, haben so weniger Anreiz, Energie zu sparen.>> Sollten Sie beim Download der PDF-Datei Probleme haben, versuchen Sie es bitte mit einem anderen Internetbrowser. <<
3361885.pdf
Creators: name: Song, Qinghai
name: Liu, Shuai
name: Sun, Wenzhao
name: wang, yujie
name: Xiaoyi, Yu
name: Xu, Ke
name: Huang, Yong-Zhen
name: Xiao, Shumin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental materials
LATERAL HABENULA AND ENDOCANNABINOID REGULATION OF STRESS-RELATED BEHAVIOR
Creators: name: Wright, Hayden Russell
Publisher: name: Washington State University
Year: 2024
Subjects: cognitive flexibility
endocannabinoid
lateral habenula
stress coping
Stress

description: Major depressive disorder (MDD) affects over 300 million people and is the largest contributor to disability worldwide. Strategies used to cope with stress impact the onset and maintenance of MDD and other stress-related disorders. Clinical and preclinical data indicate that individuals with stress-related disorders and rodents exposed to chronic stress exhibit impaired flexible decision-making and coping behaviors. The lateral habenula (LHb) is a key brain region that contributes to stress and cognitive performance via indirect projections that effectively inhibit the activity of downstream monoaminergic nuclei orchestrating behavioral responses to stress. We have shown that endocannabinoid (ECB) signaling is recruited in the LHb during stress. However, ECB contribution to stress-induced alterations in LHb activity, the impact of chronic stress on LHb recruitment during task performance, and whether the ECB system can be targeted to reverse the effects of stress remain largely unknown.
description: This dissertation details my investigation of the impact of stress on the ECB system within the LHb and its contribution to stress-induced behavior. I addressed these questions using fiber photometry, site-specific pharmacology, deep learning behavioral classifiers, and ex vivo patch clamp electrophysiology, I found that chronic stress did not disrupt operant-based behavioral flexibility but did alter LHb calcium dynamics in a sex- and stress-dependent manner, which may underlie increased task engagement. Additionally, augmentation of the cannabinoid type 1 receptor signaling within the LHb did not disrupt flexible decision-making. When I site-specifically augmented the ECB 2-arachidonoylglycerol within the LHb under conditions of acute or chronic stress, I found that it did not affect coping behavior but did reduce the activation of the medial ventral tegmental area, a major downstream dopaminergic center. Lastly, I assessed ECB regulation of inhibitory inputs to LHb neurons that project to the rostromedial tegmental nucleus (LHbRMTg) in stress-naïve and chronically stressed rats. I found that chronic stress exposure recruits ECB tone in the LHb to reduce inhibitory events in LHbRMTg neurons. However, I did not observe an effect of CUS exposure on baseline inhibitory transmission. My dissertation provides insight into the interaction between stress and ECBs to shape LHb involvement in flexible decision-making, stress coping behavior, and circuit-dependent LHb activity. My results underscore the complex nature of LHb contributions to goal-directed behavior.
Supplementary figures from Pre-copulatory reproductive behaviours are preserved in Drosophila melanogaster infected with bacteria
Creators: name: Rose, Saloni
name: Beckwith, Esteban J.
name: Burmester, Charlotte
name: May, Robin C.
name: Dionne, Marc S.
name: Rezaval, Carolina
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 60801 Animal Behaviour

description: PDF file containing all 7 supplementary figures, figure legends and extended methods.
Explainable artificial intelligence for prediction of refractory ulcerative colitis: analysis of a Japanese Nationwide Registry
Creators: name: Sano, Masaya
name: Kanatani, Yasuhiro
name: Ueda, Takashi
name: Nemoto, Shota
name: Miyake, Yurin
name: Tomita, Naoko
name: Suzuki, Hidekazu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which remission is dependent on corticosteroid (CS) treatment. The diversity of disease pathophysiology necessitates optimal case-specific treatment selection. This study aimed to identify prognostic factors for refractory UC using a machine learning model based on nationwide registry data. The study included 4003 patients with UC with a Mayo score of ≥3 at the time of registration who had been using CS since their entry out of 79,096 newly registered UC cases in a nationwide registry from April 2003 to March 2012 (before the widespread use of biologic agents in Japan) with 3-year data. A pointwise linear (PWL) model was used for machine learning. A PWL model, which was developed to predict long-term remission (lasting >3 years), had an area-under-the-curve (AUC), precision rate, recall rate, and F-value of 0.774, 0.55, 0.70, 0.62, respectively, in the test dataset from the time of registration to 2 years later. Furthermore, the presence of pseudopolyps at the time of registration was significantly and negatively correlated with remission, highlighting its importance as a prognostic factor. In this study, we constructed a highly accurate prognosis prediction model for UC, in which inflammation persists for an extensive period, by training a machine learning model for long-term disease progression. The results showed that machine learning can be used to determine the factors affecting remission during the treatment of refractory UC. A machine learning model was developed for patients who underwent CS therapy during remission induction, with remission as the outcome in the third year after treatment. The precision of the machine learning model is evident in its ability to categorize the cases into two groups with a different predicted probability of remission. A comparison of predicted and actual remission showed that the absence of pseudo-polyps and early CS withdrawal influenced remission.
A NEW EXPRESS METHOD FOR DETERMINATION OF THE THERMAL STATE OF POULTRY MEAT
Creators: name: Anton Tokarev, Veronika Lashkova
Publisher: name: TuEngr Group
Year: 2019
Subjects: Thawed poultry meat
Meat adulteration
Muscle fibers
Defrosted poultry meat
Express inspection method.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 14, 10A14J: 1-5
Computerized cardiac mapping system.
Creators: name: Bach, Thuthuy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Biomedical.

description: This thesis presents the results of the work on a computerized cardiac mapping system for recording simultaneously the signals from three electrodes placed at different sites on the heart in order to diagnose the sites causing arrhythmias. The signals are buffered, amplified, filtered and transferred to a personal computer via a multiplexing A/D converter. The computer controls the data acquisition process and stores the data in the memory. Activation times of the heart are estimated by a computer algorithm and displayed on a screen. The digitized waveforms and the vertical time marker of the activation time on each waveform are also displayed for verification. Corrections of computer-estimated activation times are possible using an interactive computer program. With this system, the region initiating an arrhythmia can be localized within a few minutes. The system has been used clinically and proved to be effective in detection of the sites of early activation causing cardiac arrhythmia.
3359870.pdf
Creators: name: Marino, Alberto
name: Dowran, Mohammadjavad
name: Kumar, Ashok
name: Lawrie, Benjamin
name: Pooser, Raphael
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Details on calibration, data taking and analysis, expected quantum sensitivity enhancement, and sensitivity order of magnitude estimation.
CLASSIFICATION SYSTEM OF SHAPING CHARACTERISTICS OF PERSONAL SERVICE ROBOTS
Creators: name: Elena Valeryevna Antipina, Konstantin Sergeevich Ivshin
Publisher: name: TuEngr Group
Year: 2019
Subjects: Robot engineering
Robotic design
Classification system for service robots
Robot design criteria
Robot characteristic design.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 14, 10A14K: 1-9
title: THREE APPLICATIONS OF TIME-SERIES ECONOMETRICS
title: ASSESSING COMMODITY PRICE RISK, FOOD PRICE INFLATION, AND MARKET INTEGRATION
titleType: Subtitle
Creators: name: Nguyen, Namloc Khac
Publisher: name: Washington State University
Year: 2024
Subjects: subject: COMMODITY PRICE RISK
subject: FOOD PRICE INFLATION
subject: MARKET INTEGRATION
subject: Econometrics
subject: FOS: Economics and business

description: The three chapters contained in this dissertation examine crop and food markets in the United States. The first chapter explores strategies for forecasting realized price volatility in commodity futures markets. This chapter also investigates whether price risk is solely a function of time length.
description: The second chapter assesses the pass-through cost of commodity price changes to retail food prices during the re-opening phase of the COVID-19 pandemic between 2021 and 2023. The second chapter also explores the impact of higher food transportation and distribution costs on retail food prices.
description: The third chapter investigates the interdependence between organic and conventional food markets, with a focus on Hass avocados in the United States. Chapter three begins by examining the relationship between organic market share and the organic price premium, and subsequently analyzes the stability of the organic price premium through an investigation of retail market integration.
GROWTH PERFORMANCE, CARCASS QUALITY, AND ECONOMICS OF PRODUCTION OF JAPANESE QUAILS FED WITH POMEGRANATE PEEL POWDER
Creators: name: Kareem Maulud Hamad, Karwan Yaseen Kareem
Publisher: name: TuEngr Group
Year: 2019
Subjects: Quail carcass quality
Quail birds
Economic return
Sensory evaluation
Japanese bird
Bird food.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 14, 10A14L: 1-7
Excess enthalpies and excess volumes for n-butyl methyl ether + n-alkane systems at 298.15 K.
Creators: name: Wang, Luo.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Chemical.

description: Research on excess properties plays an important role in solution thermodynamics. The experimental excess properties of liquid mixtures provide essential information for testing and developing solution theories. They also provide the data required for process design in chemical and petroleum industries. In addition excess properties are useful for testing thermodynamic consistency for vapor-liquid equilibrium data. Both excess enthalpies $H\sp{E}$ and excess volume $V\sp{E}$ were determined in this study for six binary systems consisting of n-butyl methyl ether and an n-alkane at 208.15 K. Flory theory with an interaction parameter, which was found to be a quadratic function of the carbon number of the n-alkane molecules, was used to correlate the experimental $H\sp{E}$ data and then to predict $V\sp{E}$ values which were subsequently compared with the experimental $V\sp{E}$ data.
Seasonal variation of phytochemicals, antioxidant and photoprotective activities from Psidium guineense sw aqueous leaves extracts
Creators: name: Colovini, Francielle
name: Horn, Priscila Aparecida
name: Zeni, Ana Lúcia Bertarello
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Chronic exposure to the sun is associated with photoaging and skin cancer and plants are an alternative for green sunscreen formulations. Psidium guineense Swartz (Sw.), a species endemic to Brazil, has been used in traditional medicine to treat inflammation and diarrhoea. This study aimed to investigate the seasonal composition and antioxidant and photoprotective activities of P. guineense leaves aqueous extract (PGLE), and the impact of climate data on the compound production for 2 years. The higher amounts of phenolics were found in the autumn and spring, by LC–MS/MS methods, showing a correlation with precipitation for phenolics and flavonoids, humidity for carotenoids, minimum and maximum temperatures for quercetin, and cloudiness for gallic acid. All seasons demonstrated high antioxidant capacity associated with phenolics, quercetin, and catechin. The high phenolic composition, carotenoids, tannins, and flavonoids were correlated with the photoprotection. Therefore, the results suggested that PGLE has potential photoprotective and antioxidant agents suitable for therapeutic applications, such as green sunscreens.
Biodiversität
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013

description: Beim Stichwort Artensterben denkt man zuerst an Nashorn oder Panda. Dabei wäre es für unser tägliches Leben sehr viel dramatischer, wenn Biene oder Regenwurm verschwinden würden! Mit einem Weniger, aber auch einem Mehr von Natur umzugehen ist die Herausforderung der Zukunft. Carsten Neßhöver zeigt anhand von Fallbeispielen und wissenschaftlichen Fakten auf, warum Biodiversität unsere wertvollste Ressource ist - und was wir tun müssen, um sie zu schützen.
Autor:
Dr. Carsten Neßhöver, Geooköloge, arbeitet am Helmholtz-Zentrum für Umweltforschung (UFZ) in Leipzig. Er koordiniert den Aufbau einer nationalen Plattform zur Biodiversitätsforschung und ist an zahlreichen internationalen Projekten, etwa der TEEB-Initiative, maßgeblich beteiligt.
Quelle: www.buchhandel.de
3361885.pdf
Creators: name: Song, Qinghai
name: Liu, Shuai
name: Sun, Wenzhao
name: wang, yujie
name: Xiaoyi, Yu
name: Xu, Ke
name: Huang, Yong-Zhen
name: Xiao, Shumin
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental materials
Die Illusion vom reinen Wasser
Creators: name: Frühschütz, Leo
Publisher: name: My University
Year: 2015

description: MINERALWASSER Spuren von Chemikalien: Darauf stoßen Labore immer öfter - selbst bei Mineralwasser. Zuletzt war es der Süßstoff Acesulfam-K. Was kann unsere Quellen schützen? von Leo Frühschütz; Quelle: http://schrotundkorn.de
Visualization of water/oil displacement in porous media in the presence of chemical reaction.
Creators: name: Gholamhosseini, Masoud.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Chemical.

description: In enhanced oil recovery, low interfacial tension, optimum wettability condition, high pH value, and the electric charge density at the interface can improve the oil recovery percentage appreciably. However, the addition of sodium hydroxide changes the interfacial tension to an ultra-low value. Interfacial tension decreases as a result of the interfacial reaction between the surface active species in the oleic phase and the caustic in the aqueous phase. The surface active species also provide favorable wettability conditions and interfacial activity which improves the recovery percentage. This study has investigated the effects of caustic concentration in the aqueous phase on the recovery percentage, and on the displacement pattern in a radial cell. The caustic solutions were employed as the displacing phase being brought into contact with the acidic oil in the cell. The displacing aqueous phase contained different concentrations of sodium hydroxide ranging from 0.0 mM to 25 mM, and the displaced phase was a light paraffin oil containing 10 mM linoleic acid. In this research, the effect of flowrate on oil recovery percentage was also examined. (Abstract shortened by UMI.)
Veterinärmedizin, Tierarzneimittel, Umwelt: Wie kann die Tiermedizin Einträge vermindern?
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: subject: Tierarzneimittel
subject: Chemikalien

description: Diese Broschüre wendet sich an Tierärztinnen und -ärzte. Sie informiert darüber, wie Tierarzneimittel in die Umwelt gelangen, erläutert deren Umweltauswirkungen und zeigt Möglichkeiten auf, wie Umweltaspekte in der täglichen tiermedizinischen Arbeit berücksichtigt werden können.
The geography of traffic accidents and risk reduction: An assessment of the Ottawa-Carleton Region.
Creators: name: Olsthoorn, Stephen J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Geography.

description: This research project evaluates the effectiveness of safety countermeasures at locations up-graded from stop sign to traffic signals in the Regional Municipality of Ottawa-Carleton. The study begins with an overview of the Region and countermeasure policies implemented by RMOC. The emphasis of the evaluation is based on the application of the "Traditional" approach and the "Probabilistic" approach to 54 locations that received traffic signals in 1986. The accident frequencies at these locations are studied using a "before-and-after" comparison and the data is standardized for risk by using traffic volume. The results indicate a substantial drop in accident rates, however, the evaluation does not indicate the level of contribution by traffic signals or by other factors. The allocation of traffic signals is evaluated in a supplementary analysis of components associated with traffic accidents. This complementary evaluation is of a "with-and-without" nature and includes a land use matrix of socio-geographic factors associated with the 54 countermeasure locations. The results indicate the presence of land use combinations common to particular locations. (Abstract shortened by UMI.)
Validation of Enterococcus faecium NRRL B-2354 as a surrogate microorganism of Listeria monocytogenes during sanitizer intervention in simulated process water
Creators: name: Liu, Andrew
name: Su, Yuan
name: ZHU, MEIJUN
Publisher: name: Washington State University
Year: 2022

description: Listeria monocytogenes, a harmful bacteria, naturally exists in the produce production and processing environment and can cause fatal illnesses. Recent listeriosis outbreaks linked to caramel apples and multiple L. monocytogenes recalls associated with fresh apples have brought apple microbial safety to the public’s attention. In commercial plants, apples are first handled by large dump tanks and flume water systems to gently transport apples from harvest bins to the packing line. The dump tank and flume system use thousands of gallons of water, making it difficult to drain and refill with fresh water. Consequently, this water is commonly reused for several processing days. However, the reuse of dump tank water results in the accumulation of organic matter and potentially cross-contamination of foodborne pathogens, including L. monocytogenes. To reduce cross contamination, chemical sanitizers like chlorine and peroxyacetic acid (PAA) are extensively used in dump tank flume water. However, their practical efficacies are largely unknown and require a non-pathogenic surrogate bacterium to test their effectiveness in-plant. In this study, the efficacy of chlorine and PAA against L. monocytogenes in simulated dunk tank water (SDTW) was analyzed using a bench-top system and further compared with a presumable surrogate, Enterococcus faecium NRRL B-2354. Chlorine at 25-100 ppm for 0.5-5 min contact in water with 1000 ppm chemical oxygen demand (COD) caused a reduction of 4.5-6.0 log10 CFU/ml in L. monocytogenes, while reductions of 3.8-5.2 log10 CFU/ml were observed for that of E. faecium. PAA at 20 and 80 ppm for 0.5-5 min contact in water with 1000 ppm COD reduced L. monocytogenes by 0.7-3.8 and 3.9-4.3 log10 CFU/ml, respectively; which was comparable to the 0.4-3.6 and 3.3-4.3 log10 CFU/ml reduction observed for that of E. faecium. In summary, we proved E. faecium is a suitable surrogate microorganism of L. monocytogenes in chlorine and PAA intervention treatments in SDTW water.