cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of High-resolution analysis of selection sweeps identified between fine-wool Merino and coarse-wool Churra sheep breeds
Creators: name: GutiĂŠrrez-Gil, Beatriz
name: Esteban-Blanco, Cristina
name: Wiener, Pamela
name: Chitneedi, Praveen
name: Aroa Suarez-Vega
name: Juan-Jose Arranz
Publisher: name: Figshare
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1. Phenotypic, production and reproductive traits of Spanish Churra and Australian Merino sheep breeds.
Active targeting of nanocarriers to tumor-specific glycosaminoglycans
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The central hypothesis of this proposal is that active targeting of therapeutic nanocarriers to solid tumor regions is best achieved by targeting the glycosaminoglycan polysaccharides found on tumor surfaces and in the surrounding extracellular matrix. All tumors express glycosaminoglycans. Tumor glycosaminoglycan compositions are structurally and functionally different from normal tissue. In those tumor models that have been studied, this glycosaminolgycan dysregulation appears essential for the progression to malignancy. This project will establish the science and methodology that will identify targeting ligands that selectively recognize, with high affinity, tumor-specific glycosaminoglycans found in tumor regions. The specific aims are: 1) Establish the well-characterized C-26 tumor model in BALB/c mice. 2) Isolate, identify, and fluorescence-label the glycosaminoglycans of these tumors. 3) Using combinatorial selection procedures, select for amino acid sequences that bind the tumor glycosaminoglycans with high affinity, but do not bind the glycosaminoglycans of the reticuloendothelial system (liver+spleen). 4) Incorporate the high affinity peptides into a liposomebased nanoparticle delivery system already proven to target glycosaminoglycans in vivo. 5) Evaluate these candidate formulations with biophysical and cell culture methods to confirm their active targeting characteristics prior to administration in vivo. 7) Administer these active targeting liposome systems to tumor-bearing mice. 8) Demonstrate effective active targeting to tumorspecific glycosaminoglycans in vivo, and away from normal organs. 9) Demonstrate superior chemotherapy and reduction in tumor volume compared to passive targeting liposomes and free drug. Because all tumors express glycosaminoglycans, the results of this study should contribute to the development of tumor targeting strategies that are nearly universally applicable to all tumor systems. Also, the targeting strategy proposed here should be applicable for incorporation into a wide variety of nanocarrier systems currently in use, under development, or developed with future nanotechnology research.
Scorpiops zhangshuyuani
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops zhangshuyuani

description: (35) Scorpiops zhangshuyuani (Ythier, 2019)
TYPE LOCALITY AND TYPE DEPOSITORY. China, Yunnan Province, Dehong Dai and Jingpo Autonomous Prefecture, Yingjiang County, Tongbiguan Township; MNHN.
PROTONYM. Euscorpiops zhangshuyuani Ythier, 2019.
CHINESE EQUIVALENT. 张氏ẍx.
DISTRIBUTION (●). Yunnan: Dehong Prefecture (Yingjiang County: Tongbiguan Township);?Lincang City (Cangyuan Va, Gengma Dai and Va, and Zhenkang (Nansan Town) counties).
REMARKS. Populations recently reported from Lincang City in Tang & Šťáhlavský (2024) require further study.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 19, DOI: 10.5281/zenodo.14660932
Eleotris picta Kner 1863
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Eleotris
Eleotris picta

description: Eleotris picta Kner 1863. Small-Scaled Spotted Sleeper; Guavina, Vieja, Pez Perro, Dormilón, Dormilón Manchado
Vouchers: UCR 0052-002 (47), 0184-004 (1), 0187-002 (51), 0270-003 (33) and 0272-003 (1). Distribution: Eastern Pacific Ocean; from the mouth of the Gulf of California, Mexico, to northern Peru, including Cocos and the Galapagos islands; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER, PN and Ni (Pacific); 0–25 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend stable. Literature: Villa (1982: 222; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 416; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Robertson & Allen (2015: 1975; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 34; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 33, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
DNA tethers: a novel mechanism of segregating acentric chromosomes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cells maintain a number of robust mechanisms for repairing both single-strand and double-strand breaks (DSB). The latter are particularly problematic and failure to repair DSBs not only results in chromosome fragments with unprotected ends, but also fragments lacking centromeres. These acentric (lacking centromeres) chromosome fragments would be expected to be incapable of poleward segregation during anaphase; however recent work in our lab has revealed a distinct DNA-tether based mechanism of segregating acentric chromosome fragments to the poles. Using the I-CreI endonuclease to make a single site specific break at the base of the Drosophila X chromosome, we liveimaged chromosome segregation in neuroblasts and discovered that sister acentrics segregate properly to the opposing poles. The mechanism of segregation appears to be through DNA tethers coated with BubR1 and Polo kinases connecting the centric and acentric chromosome fragments. Here we present experiments to understand the mechanisms responsible for generating these tethers and the mechanisms by which sister acentrics properly segregate to opposing poles in the absence of functional kinetochores. Finally, genetic screens are proposed to more comprehensively define the nature and structure of tethers. As DNA tethers may prove to be an important mechanism by which eukaryotic genomes preserve integrity, it has important implications for basic and applied cancer research.
Tetramorium ocothrum Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium ocothrum

description: Tetramorium ocothrum sp. n.
(Fig. 57)
Holotype worker. TL 2.9, HL 0.64, HW 0.56, CI 87, SL 0.47, SI 84, PW 0.42, AL 0.70.
Antennae with 12 segments. Mandibles delicately longitudinally striate. Anterior clypeal margin convex and entire. Frontal carinae reaching a level about halfway between posterior margins of eyes and occipital corners, weak throughout their length, no stronger than the cephalic sculpture with which they merge posteriorly. With head in full-face view the sides evenly convex, the occipital margin transverse, not concave medially. Eyes moderate, maximum diameter 0.12, about 0.21 x HW, situated in front of the midlength of the sides. Dorsal alitrunk evenly convex in profile, in dorsal view the pronotal corners rounded. Propodeal spines short, narrow and spiniform, slightly longer than the acute triangular metapleural lobes. Petiole in profile with a long, downcurved anterior peduncle and a low dome-shaped node with broadly rounded antero- and posterodorsal angles and an evenly convex dorsum. In dorsal view the petiole node subglobular, slightly broader than long. Postpetiole with an anterior peduncle which is narrower than the node itself, the whole segment longer than broad. Dorsum of head covered with a mass of fine, irregular, dense confused regulation, the interspaces finely punctulate. Dorsal alitrunk with a fine open rugoreticulum. Petiole and postpetiole unsculptured dorsally but the former with lateral traces of faint punctulation. Gaster unsculptured. All dorsal surfaces of head and body with numerous elongate fine hairs but the dorsal (outer) surfaces of the hind tibiae only with short, appressed pubescence. Colour black.
Holotype worker, Borneo: Sarawak, 4 th Division, Gunong Mulu Nat. Pk, RG. S .. Expd. Long Pala, lowl. rainfor., on tree trunk, 14. X. 1977 (B. Bolton) (BMNH).
A species of the tonganum-group, most closely related to tonganum itself and running out with that species in the key (Bolton, 1977: 77). The two are quickly separable by colour, tonganum being yellowish brown or mid-brown whilst ocothrum is black. Apart from this the eyes of tonganum are slightly larger (0.24 - 0.27 x HW) and the cephalic sculpture is more regular, not so nearly disorganized in appearance as in ocothrum.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 176
The oncogenic role of cten in colon cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Focal adhesions are the transmembrane junctions between the extracellular matrix and the cytoskeletal network, and are believed to regulate biological events such as cell adhesion, migration, proliferation, differentiation, and gene expression. When the regulation process goes awry, it may lead to cell transformation and cancer development. Our global objective is to understand the role of focal adhesions in cell structure and signaling pathways, in preventing cell transformation, and bring this research to a clinical application. Tensin is a focal adhesion molecule that links the actin filaments to integrins and mediates various signaling pathways. Our laboratory has identified all four tensin family members in mammals. Previous studies on cten were focused on its roles in the prostate due to cten’s restricted expression pattern. We have found cten is downregulated in prostate cancer and one of cten’s functions is to recruit a tumor suppressor DLC1 to focal adhesion sites, which is essential for DLC1’s tumor suppressor activity, implicating a role of cten as a tumor suppressor in prostate epithelia. On the other hand, cten is up-regulated by EGF and promotes cell migration/invasion by modulating integrin-actin linkages at focal adhesion sites. Our recent studies have shown that although cten is not expressed in normal colon tissues, cten is overexpressed in 76% of colon cancer samples. In addition, cten travels to the nucleus and is involved in the canonical Wnt pathway. These results suggest that cten may possess an oncogenic activity in the colon. We hypothesize that cten is participated in the canonical Wnt signaling and up-regulation of cten in the colon is a critical step in increasing the risk for colon cancer. To test this hypothesis in this proposal, we want to demonstrate the function of cten in tumor progression using transgenic and compound mutant mice. By doing so, we not only determine the oncogenic effect of cten but also establish better mouse models for colon cancer.
Properties and solutions of a class of stochastic programming problems with probabilistic constraints
Creators: name: Yoda, Kunikazu
Publisher: name: No Publisher Supplied
Year: 2013

description: We consider two types of probabilistic constrained stochastic linear programming problems and one probability bounding problem.    The first type involves a random left-hand side matrix whose rows are independent and normally distributed. The quasi-concavity of the constraining function needed for the convexity of the problem is ensured if the factors of the function are uniformly quasi-concave. A necessary and sufficient condition is given for that property to hold. We show practical application in optimal portfolio construction.    The second type is the stochastic multidimensional knapsack problem which involves a random left-hand side matrix with independent components and 0-1 decision variables. We show that the problem is convex, under some condition on the parameters, for special continuous and discrete distributions: gamma, normal, Poisson, and binomial. Numerical experiments suggest that the problem can be solved as efficiently as its deterministic version for moderate sized instances.    In the last problem, we formulate the linear programming problems that give improved lower and upper bounds on the probability of the union of events when the probabilities of some individual or intersections of events in a first few terms of the inclusion-exclusion principle are 0 or very small.
Role of the IDH1R132 mutation in glioblastoma methylation and response to treatment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The IDH1R132 mutation has been found to be an early event in gliomagenesis with prognostic implications and likely mechanistic importance. IDH1 is a component of the citric acid cycle responsible for generation of NADPH, which is critical for removal of reactive oxygen species produced by normal mitochondrial activity. In preliminary studies, we have found that IDH1 mutation is associated with a CpG island hypermethylation signature in patient glioma tumor tissue. Phenotypic analysis of our large glioblastoma patient cohort confirms other studies demonstrating an association of IDH1R132 with improved survival. CpG island methylation is important for glioblastoma response to therapy based on improved survival of patient with MGMT promoter methylation treated with temozolomide. We hypothesize that IDH1R132 sensitizes glioblastoma cells to radiation and temozolomide treatment and promotes changes in global CpG island (promoter) methylation as a possible mechanism by which IDH1R132 may mediate its effects on phenotype. To explore these hypotheses, the proposed aims are: Aim 1: To determine whether overexpression of the IDH1R132 sensitizes cultured glioblastoma cells to radiation and temozolomide. Aim 2: To determine whether overexpression of IDH1R132 can promote methylation of MGMT and development of a genome-wide hypermethylation signature in cultured glioblastoma cells. Aim 3: To determine whether the IDH1R132 –associated hypermethylation signature is present in neurospheres harboring IDH1R132. This proposal represents a logical extension of my current research efforts. The link between IDH1R132 and methylation is based on preliminary data generated using a methylation profiling assay recently developed in my laboratory. A collaboration with Dr. Kornblum has been established to investigate the role of IDH1R132 in stem cells (neurospheres).
Stimuli-responsive and versatile liposomes for cancer-targeted chemotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chemotherapy is the predominant cancer treatment method and often the sole option to cure metastasized and hematogenous cancers. To address limitations in current methods, chemoagent delivery using nano-sized carriers can provide improved pharmacokinetics in vivo, controlled drug release, and selective accumulation of the drugs in target tumor tissues. Although liposomes are promising cancer drug carriers, offering high biocompatibility and efficient loading of both hydrophilic and hydrophobic drugs, their lack of responsiveness to cancer-specific stimuli, limited tunability via chemical modifications, and low stability need to be improved. The proposed research will use relatively unstable liposomes to encapsulate a clinically used chemoagent, doxorubicin, within a structurally reinforced but acid-degradable polymeric shell (drug encapsulating acid-responsive shelled liposomes). During circulation, the acid-responsive shelled liposomes shield the drug from destructive external conditions. However, in a mildly acidic tumor or cell, the outer polymeric shell degrades, destabilizing the liposomes and releasing the encapsulated drugs. Preliminary studies synthesized the acid-responsive shelled drug carriers by surface-initiated photopolymerization of acid-degradable monomers and cross-linkers onto doxorubicin-encapsulating liposomes. These studies demonstrated the feasibility of acid-triggered release of doxorubicin from disintegrated (de-shelled) liposomes under mildly acidic conditions. The proposed research will further investigate this novel drug delivery system. First, it will compare extracellular and intracellular release of doxorubicin from the acid-responsive shelled liposomes under physiological, intratumoral, and endosomal conditions, and investigate the liposome’s cytotoxic effects under such conditions. Second, the project will investigate the acidresponsive shelled liposomes’ pharmacokinetics and biodistribution. The acid-responsive shelled liposomes’ efficient tumor eradication will demonstrate the translational potential of this stimuliresponsive and versatile drug delivery carrier for cancer-targeted chemotherapy. In the future, the proposed research will be expanded to combine diagnosis and therapy, and to deliver multiple therapeutics, generating immediate and significant impacts on cancer therapy.
Promoting high school graduation in a predominantly Latino/a community
Creators: name: Simon, Patricia
Publisher: name: No Publisher Supplied
Year: 2013

description: Research has shown that school-based prevention programs can prevent substance misuse and promote graduation. Few studies have investigated high school-based programs, their long-term effects, and their intervening processes. Prosocial bonding to an entity outside of oneself has been theoretically (Finn, 1989; Hirschi, 1969) and empirically (McNeely & Falci, 2004) associated with positive behavioral outcomes for youth and rarely studied as a mediator of school-based prevention program effects.  The current study examined the impact of Peer Group Connection (PGC) on students’ marijuana use and high school graduation.  This study also examined school belonging as a mediator and acculturation as a moderator of potential program effects. In 2005, 268 students (92% Latino) were randomized to the control (n = 1&5) or program (n = 93) condition. Trained upperclassmen delivered weekly forty-minute, manualized sessions to ninth grade students. Latent growth curve analysis, using baseline, post-test, one-year follow-up, and two-year follow-up data showed an interaction. Specifically, the more acculturated PGC participants were more likely to graduate than similar controls (84.6% vs. 60.3%, respectively; Pseudo R-square = 9%).   No evidence was found that school belonging mediated this effect. No intervention effect was observed for marijuana use. Thus, there is evidence that PGC benefited the Latino students who were most at risk for school dropout in this sample—those who were most acculturated.
Didymoglossum hildebrandtii (Kuhn) Ebihara & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum
Didymoglossum hildebrandtii

description: Didymoglossum hildebrandtii (Kuhn) Ebihara & Dubuisson
MADAGASCAR: Nosy Mangabe, Piste reliant le camp Isidore au point culminant de l’île, sur le versant ouest, 2 Dec. 1993, F.Rakotondrainibe 1865 (P0006060).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 51, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Hypoxic signaling in epigenetic regulation of DNA mismatch repair in IBD-associated colon cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic inflammation in inflammatory bowel disease patients is an established risk factor for colorectal cancer (CRC). Colitis associated colon cancer (CAC) differs from sporadic CRC’s, being more likely to be right-sided, multifocal, arise from areas of flat dysplasia, and feature microsatellite instability (MSI). Importantly, MSI is an early finding in pre-neoplastic IBD mucosa, arising before the development of CAC. In sporadic CRC with MSI, a majority of cases are due to hypermethylation of the proximal Mlh1 promoter, a gene involved in DNA mismatch repair. However, hypermethylation is present in only a minority of MSI+ CAC, suggesting the presence of additional Mlh1 silencing mechanism(s). In our animal model of CAC, we have identified mucosal hypoxia and HIF target gene activation as a trigger that silences Mlh1 via epigenetic histone modifications, rather than promoter hypermethylation. (1). We will test the hypothesis that hypoxic inflammation induces epigenetic silencing of the Mlh1 locus in human IBD mucosa by inducing HIF target gene expression that results in repressive histone modifications. We will also test the hypothesis that constitutive colonic HIF activation potentiates carcinogenesis in the AOM-DSS mouse model of CAC. In the first aim, using fresh human IBD mucosal biopsies we will correlate colitis activity with HIF target gene expression, Mlh1 expression, MSI, and (by ChIP analysis using Fast-CChIP) the epigenetic histone signature at the proximal Mlh1 promoter. In the second aim, using the carcinogen AOM alone or in combination with DSS, we will induce CRC and CAC in transgenic mice with constitutive intestinal HIF signaling in order to determine whether constitutive HIF signaling alone or in combination with chronic colitis results in epigenetic Mlh1 silencing, MSI and the development of CAC. These studies will establish whether HIF signaling-induced histone modifications contribute to the development of MSI and CAC in human IBD patients, and will have broader implications for hypoxic and inflammatory signaling in solid organ carcinogenesis
Tetramorium obtusidens
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium obtusidens

description: The obtusidens -complex
In the previous part of this study (Bolton, 1977: 101) a number of samples were treated under the name T. obtusidens Viehmeyer, and I said at the time that, ' I suspect that the name obtusidens may conceal more than one valid species'. Now I am of the opinion that three separate species exist in this complex of the bicarinatum-group. They are characterized within the group by their small size (HW <0.65, SL <0.55), smooth unsculptured mandibles, pale yellow colouring and vestigial or absent basigastral sculpture. All three will run out to obtusidens in the 1977 key but may be separated as follows.
a Alitrunk in dorsal view with a strong transverse carina at the pro-mesonotal junction. Postpetiole dorsum with strong rugulose sculpture. (Thailand, Borneo) ... adelphon (p. 177)
- Alitrunk in dorsal view without a transverse carina at the pro-mesonotal junction. Postpetiole dorsum punctulate or with 1 - 2 very faint rugulae ........ b
b Hairs on dorsal alitrunk abundant, fine, curved or sinuate. Smaller species, HW <0.55. (Singapore) ........... obtusidens (p. 178)
- Hairs on dorsal alitrunk sparse, stout, more or less straight and blunted apically. Larger species, HW> 0.55. (New Guinea) ....... kydelphon (p. 177)
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 177
Erotelis armiger
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Erotelis
Erotelis armiger

description: Erotelis armiger (Jordan & Richardson 1895). Armiger’s Goby, Flathead Sleeper; Guavina Cabeza Plana, Gobio de Armiger
Vouchers: (other collections) MCZ 173383 (1). Distribution: Eastern Pacific Ocean; from the lower Gulf of California, Mexico, to Colombia; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN (Pacific); 0–8 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; DD (2010), population trend unknown. Literature: Villa (1982: 223; detailed description, including illustrations and an identification key, and information on distribution and ecology), Robertson & Allen (2015: 1977; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 34; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 33, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Didymoglossum robinsonii (Hook. ex Baker) Copel.
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum
Didymoglossum robinsonii

description: Didymoglossum robinsonii (Hook. ex Baker) Copel.
SOUTH AFRICA: Natal, Zululand, Ngoya forest, May 1916, J.R.Sim 2984 (P01627659).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 51, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Tetramorium adelphon Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium adelphon

description: Tetramorium adelphon sp. n.
Holotype worker. TL 2.8, HL 0.68, HW 0.58, CI 85, SL 0.48, SI 83, PW 0.43, AL 0.78.
Antennae with 12 segments. Mandibles unsculptured, smooth and shining with scattered hair-pits. Anterior clypeal margin with a shallow median impression. Frontal carinae strong and running almost to occipital corners before blending into the occipital rugoreticulum, and surmounted to this point by a narrow raised rim or flange. Maximum diameter of eye 0.17, about 0.29 x HW. Propodeal spines in profile elongate and narrow. Metapleural lobes triangular, broad basally but rapidly tapering to an acute apex. Petiole node in profile shaped as in insolens (Fig. 45, this paper), longer than broad in dorsal view. Clypeus sculptured only with the three longitudinal carinae typical of this group. Dorsum of head in front of the level of the eyes with 5 longitudinal rugulae between the frontal carinae, occipitally with a strong rugoreticulum and between these two zones with an area in which the longitudinal rugulae continue but which also has a few cross-meshes. Dorsal alitrunk reticulate-rugose and with a strong transverse carina at the junction of pro- and mesonotum. Petiole dorsum reticulate-rugulose, postpetiole dorsum similarly but less strongly sculptured. First gastral tergite without basal costulae. All dorsal surfaces of head and body with stout, stiff erect or suberect hairs. Colour pale yellow.
Holotype worker, Borneo: Sarawak, 4 th Division, Gunong Mulu Nat. Pk, R. G. S. Expd. Long Pala, lowl. rainfor., leaf litter, 28. ix. 77 (B. Bolton) (BMNH).
NON-PARATYPIC MATERIAL
Also placed in this species is a single worker from Thailand: Nong Hoi, 21. vii. 1975 (D. Jackson) which closely resembles the holotype but has the anterodorsal petiole angle rather more acutely developed. It has almost the same measurements as the holotype (TL 3.0, HL 0.70, HW 0.61, CI 87, SL 0.50, SI 82, PW 0.44, AL 0.80) and shares the diagnostic characters of the holotype. The strong transverse carina on the dorsal alitrunk quickly separates adelphon from related species in the Oriental and Indo-Australian regions, but this character also occurs in the small yellow African species related to phasias Forel, which may turn out to be more closely related to adelphon than either obtusidens or kydelphon.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 177
First annual report: Mosquito Extermination Commission
Creators: name: O'Brien, John
Publisher: name: No Publisher Supplied
Year: 1912

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Additional file 1: Table S1. of microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer
Creators: name: Takahashi, Hidekazu
name: Takahashi, Masanobu
name: Ohnuma, Shinobu
name: Unno, Michiaki
name: Yoshino, Yuki
name: Ouchi, Kota
name: Takahashi, Shin
name: Yamada, Yasuhide
name: Shimodaira, Hideki
name: Ishioka, Chikashi
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Clinical characteristics of patients with colorectal cancer in this study. Table S2. Tumor response of patients with colorectal cancer who received anti-EGFR therapy based upon the miR-193a-3p expression status. Table S3. Tumor response of patients with KRAS/BRAF-wild-type colorectal cancer who received anti-EGFR therapy based upon the miR-193a-3p expression status. (DOCX 27Â kb)
Developing nutrient transporter down-regulation as a novel approach to cancer therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Because they are locked into a pro-growth, biosynthetic program by their constitutively active oncogenes and the loss or inactivation of tumor suppressor proteins, cancer cells are hypersensitive to treatments that limit intracellular nutrients. My lab is taking a unique approach to the cancer problem by developing drugs that induce nutrient transporter loss as potential cancer chemotherapeutics. Many groups have shown that FTY720 blocks tumor growth and metastasis in animal models without producing toxicity. We have shown that the anti-neoplastic effects of FTY720 result from its ability to coordinately down-regulate nutrient transporter proteins. Cells are rescued from FTY720 by preventing nutrient transporter loss, supplementing the medium with cell permeable nutrients, or by adjusting cellular metabolism. Transporter loss is independent of sphingosine-1-phosphate receptor activation and did not require increased ceramide production. Inhibiting PP2A, however, blocked FTY720-induced transporter loss. Importantly, FTY720 also down-regulated nutrient transporters and selectively killed leukemia cells in vivo. These results demonstrate that reducing nutrient transporter expression is a feasible, safe, and effective approach to cancer therapy. However, FTY720 itself cannot be used in humans due to side effects resulting from S1P receptor activation. We have identified an FTY720 analog that does not activate S1P receptors but retains the ability of FTY720 to trigger amino acid transporter down-regulation suggesting that this drug might eventually be used in human cancer patients. We will begin to test this hypothesis by: 1) Determining whether this drug affects global nutrient uptake and cellular bioenergetics in a similar manner to FTY720. Whether diverse nutrient transporter proteins are down-regulated in multiple cell types, nutrient uptake is reduced, and whether anabolic cells are selectively killed in a manner that is reversed by cell permeable nutrients will be tested. 2) Establishing whether this compound is as effective as FTY720 at limiting leukemogenesis in vivo. We will use our BCR-Abl driven leukemogenesis model to confirm this drug induces nutrient transporter loss and selectively kills leukemia cells in vivo. By simultaneously targeting multiple transporter proteins, drugs with this mechanism of action could be “magic bullets” in the fight against many different types of cancer: regardless of whether a tumor uses glucose, glutamine, or an alternative nutrient as its p
Targeting homologous recombination in melanoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Melanoma is a major health concern especially in Caucasians for whom the mortality in the U.S. has increased dramatically in recent years. Although UV exposure is a known risk factor for both melanoma and non-melanoma skin cancer, the relationships differ which may be important in devising rational therapies. The role of UV exposure in melanoma is complex and remains to be completely resolved. Melanomas show similar distributions in normal and XP patients but are not restricted to the areas of sun exposure and correspond more to intermittent sunburns than total accumulated doses as found for squamous cell carcinomas. The BRAF mutation (V600E) has been identified as an important activating mutation in melanoma on the RAS pathway, but this does not appear to be a UV-type mutation, so may not be a candidate gene for understanding the UV response of melanocytes and melanomas. In contrast the PTEN tumor suppressor gene has recently been found to contain a high frequency of UV type mutations dipyrimidine sequences in melanomas, raising the possibility that this is a relevant target gene for sun-induced melanomas. A recent report suggests that PTEN plays a role in homologous recombination (HR). In view of the importance of PTEN in many human cancers, resolution of its role is important, especially because tumors with PTEN mutations should be sensitive to inhibitors of Poly (ADP-ribose) polymerase (PARP-1), as are other tumors with mutations that affect HR such as breast cancers. We will determine the role of PTEN in HR after exposure of melanocytes and melanoma cell line using immunohistochemistry for the Rad 51 marker that regulated early strand invasion during HR, and an integrated vector engineered to detect successful HR. The vector consists of two tandemly arranged green fluorescent protein genes that are individually nonfluorescent due to engineered defects. Homologous recombination between them produces fluorescent cells that can be visualized in FACS scans. This represents a fast approach to detecting successful HR and evaluating the mechanism of PTEN interaction with HR. The sensitivity of melanomas with mutations in BRAF or PTEN to a range of inhibitors of HR and PARP-1 will then be determined to ascertain the prospects for these agents for therapies, alone or in conjunction with BRAF inhibitors. These in vitro experiments will lay the ground-work for possible future applications to melanomas of PARP-1 inhibitors that have been successfully used in breast cancer clinical trial
Role of CtIP in DNA replication
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: DNA damage checkpoints in conjunction with repair factors are instrumental for maintaining the integrity of the genome. Defective or incorrect activation of the surveillance and DNA repair system can result in increased mutagenesis, genome instability, premature aging, and ultimately cancer. In comparison to G1 and G2 phases, the S-phase DNA replication is much more susceptible to genotoxic stresses. Initiation of DNA replication at origins is inhibited when DNA is damaged, and this inhibition is mediated in part by standard DNA damage checkpoint proteins. The mechanisms by which checkpoint proteins inhibit replication initiation are still partly unclear. CtIP, CtBP-interacting protein, is a multivalent adaptor. It interacts directly with pRB family members, the prototype tumor suppressor proteins, and contributes to G1/S regulation. It has also been implicated in DNA damage checkpoint control through its interaction with the breast cancer susceptibility gene product BRCA1. It was also found to modulate the nuclease activity of the Rad50/Mre11/NBS1 complex. Recently we found that CtIP is targeted to DNA replication foci by direct interaction with PCNA. A 42-amino acid region of CtIP mediated the interaction between CtIP and PCNA. Overexpression of the PCNA interacting region of CtIP induced DNA damage and activation of DNA damage checkpoint. These results suggest that the CtIP-PCNA complex might play a role in stabilization of the stalled replication forks. Since CtIP plays a role in DNA repair, it is possible that the normal function of the PCNA-CtIP complex might be involved in surveillance of the replication forks for potential stalling. To further explore the role of CtIP in DNA replication, we plan to use a panel of cell clones bearing inducible RNAi cassette to tease out the biological significance of each interaction of CtIP. Since these different protein-protein interactions have been mapped to different regions of CtIP, correlating each biological function to a specific interaction can be readily achieved. Using powerful RNAi-mediated gene silencing to target various CtIPassociated factors, we hope to gain improved understanding of the involvement of CtIP-containing complexes in the DNA replication checkpoint control.
Polymeric plasticizers prepared by controlled polymerization: A substitute for phthalate endocrine disruptors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Polymeric phthalates will be developed for use as plasticizers as blends with polyvinyl chloride (PVC). Small molecule phthalate esters are currently used on the multi-million ton scale worldwide in the formulation of PVC consumer products. These phthalates leach from the polymer matrix: when metabolized, they become endocrine disruptors, implicated in a variety of severe health problems including testicular, breast and liver cancer, developmental abnormalities and infertility. Well-defined, short polymers containing pendant phthalate esters will be prepared by nitroxide mediated radical polymerization (NMRP). The synthesis of the key monomers, 4-vinylphthalic esters, will utilize a Suzuki-Miyaura coupling of the corresponding 4- bromophthalates. NMRP will be carried out to prepare homopolymers and random copolymers with acrylate “spacers.” Optimization of the alcohol (branching and size) on the phthalate esters and acylate spacers, the molecular weight of the polymers (2 000 – 10 000), and the amount of comonomer will be investigated to formulate PVC blends that show the desired miscibility and plasticization properties, as determined by IR, DSC, and depressed Tg. PVC blends should show long-term homogeneity and chemical stability. The polyphthalates will be tested to ensure they do not migrate out of the PVC matrix. The successful outcome of this project will have a huge beneficial impact on human health. Children are particularly sensitive to the effects of leached phthalate plasticizers, although all humans are exposed to large quantities of these hormone disruptors. Small molecule plasticizers leach out into the environment, disrupting the metabolism of wildlife, and generations of future humans. By developing a polymer-supported version of phthalate plasticizers, these materials are expected to be resistant to leaching. In addition, due to the robust all-carbon polymer backbone, any polyphthalates that may be ingested cannot be metabolized into hormone mimics. This substitute for small molecule phthalate plasticizers could revolutionize the plastics industry: most immediately providing solutions for children's products, food packaging, and medical applications.
Liocheles australasiae
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Hormuridae
Liocheles
Liocheles australasiae

description: (1) Liocheles australasiae (Fabricius, 1775)
TYPE LOCALITY AND TYPE DEPOSITORY. “In the islands of the Pacific Ocean” (in insulis Oceani pacifici); NHMUK.
PROTONYM. Scorpio australasiae Fabricius, 1775.
SYNONYMS. Ischnurus complanatus C. L. Koch, 1837; Scorpio gracilicauda Guérin Méneville, 1843; Scorpio (Ischnurus) cumingii Gervais, 1844; Chactas brunneus Bellevoye, 1870; Ischnurus pistaceus Simon, 1877; Hormurus australasiae var. γ suspectus Thorell, 1888; Buthus brevicaudatus Rainbow, 1897; Hormurus australasiae brevidigitatus Werner, 1936.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 19, DOI: 10.5281/zenodo.14660932
Evaluating the role of chronic stress in cancer-related fatigue: Links with inflammation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In 2006, there were over 11.4 million cancer survivors in the US, and women with a history of breast cancer account for nearly a quarter of US cancer survivors. More than two-thirds of individuals diagnosed with cancer today can expect long-term survival or cure, primarily due to the earlier detection and successful treatment of the disease. For many individuals with cancer, improved survival is complicated by long-term effects of treatment. Fatigue is the most common and disabling side effect of breast cancer treatment and may persist for months or years after successful treatment completion. Approximately one-third of breast cancer survivors experience severe and persistent fatigue that causes serious disruption in quality of life. Growing evidence implicates an inflammatory basis for cancer-related fatigue. However, risk factors for chronic inflammation and associated symptoms of fatigue have not been determined. Exposure to stressful life events is associated with development of fatigue in non-cancer samples, and there is also compelling evidence linking stress and inflammation. Thus, stress may be a key vulnerability factor for cancer-related fatigue. The primary objective of the proposed study is to evaluate the role of cumulative stress exposure in post-treatment fatigue, and to examine links between stress exposure and inflammation. Breast cancer survivors with persistent fatigue and a comparison group of non-fatigued survivors will complete state-of-the-art measures of life stress, focusing on stress exposure prior to cancer diagnosis. We have previously documented elevations in markers of inflammation in this sample of survivors; the proposed study will build on these findings and probe the association between stress exposure, fatigue, and inflammation.
Didymoglossum lenormandii (Bosch) Ebihara & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum
Didymoglossum lenormandii

description: Didymoglossum lenormandii (Bosch) Ebihara & Dubuisson
MADAGASCAR: Montagnes à l’Est d’Ambo, Sep. 1908, H.Perrier de la Bâthie 7733 (P00466418, P00466417); Manankazo, Réserve spéciale d’Ambohitantely, 24 Jun. 1984, F.Rakotondrainibe 201 (P00064792); Eminiminy, 12 Nov. 1995, F.Rakotondrainibe 3096 (P00067201); Réserve Spéciale d’Ivohibe, 28 Oct. 1998, F.Rakotondrainibe 4266 (P00134299); PN de Ranomafana, Forêt de Vatoharanana, 5 Oct. 2000, F.Rakotondrainibe 5914 (P00212395); PN de Marojejy, 16 Oct. 2001, F.Rakotondrainibe 6260 (P00243910).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 52, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401