title: Ð Ð°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð¸ÑÑÑÑÐµÐµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð±Ð¾ÑÐ° Ð½Ð° Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐµ ÐºÐ»ÐµÑÐºÐ¸ in vitro Ð¿ÑÐ¸ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¾ÑÐ¾Ð½Ð°Ð¼Ð¸ Ð½Ð° Ð¿Ð¸ÐºÐµ ÐÑÑÐ³Ð³Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Radiosensitizing effect of boron compounds on cancerous cells irradiated at the proton Bragg peak in vitro
Creators: name: ÐÐ°ÑÐ¸Ð½Ð°, ÐÐ»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð¿ÑÐ¾ÑÐ¾Ð½Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð¿Ð¸Ðº ÐÑÑÐ³Ð³Ð°
Ð±Ð¾Ñ
ÑÐ°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾Ñ
Ð±Ð¾Ñ-Ð¿ÑÐ¾ÑÐ¾Ð½Ð·Ð°Ñ Ð²Ð°ÑÐ½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð³Ð»Ð¸Ð¾Ð¼Ð°
Ð³Ð°Ð¼Ð¼Ð°-Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ðµ
proton radiation therapy
bragg peak
boron
radiosensitizer
proton boron capture therapy
glioma
gamma irradiation

description: ÐÑÐ¾ÑÐ¾Ð½Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÑÑÑ Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¼Ð½Ð¾Ð³Ð¸Ñ Ð²Ð¸Ð´Ð¾Ð² Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹. ÐÐ»Ð°Ð³Ð¾Ð´Ð°ÑÑ ÑÐ½Ð¸ÐºÐ°Ð»ÑÐ½ÑÐ¼ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°Ð¼ Ð¿ÑÑÐºÐ¾Ð¼ Ð¿ÑÐ¾ÑÐ¾Ð½Ð¾Ð² Ð¾Ð±Ð»ÑÑÐ°ÑÑ ÑÑÑÐ´Ð½Ð¾Ð´Ð¾ÑÑÑÐ¿Ð½ÑÐµ Ð´Ð»Ñ ÑÐ¸ÑÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¼ÐµÑÐ°ÑÐµÐ»ÑÑÑÐ²Ð° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸. ÐÐ´Ð½Ð°ÐºÐ¾ ÐµÑÑÑ ÑÑÑÐ´Ð½Ð¾ÑÑÐ¸ Ð² ÑÐ¸ÑÐ¾ÐºÐ¾Ð¼ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¾ÑÐ¾Ð½Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. ÐÐ½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐ¸ÑÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð»ÑÑÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¼Ð¾Ð¶ÐµÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐ°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾ÑÐ¾Ð². ÐÐµÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ, ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐ¸Ðµ 10Ð ÑÐ¶Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÑÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ ÑÐ°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾ÑÐ¾Ð² Ð² Ð±Ð¾Ñ-Ð½ÐµÐ¹ÑÑÐ¾Ð½-Ð·Ð°ÑÐ²Ð°ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. ÐÑÐ»Ð¾ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ ÑÑÐ¸ Ð¶Ðµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ Ð² Ð¿ÑÐ¾ÑÐ¾Ð½Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð·Ð° ÑÑÐµÑ ÑÐ´ÐµÑÐ½Ð¾Ð¹ ÑÐµÐ°ÐºÑÐ¸Ð¸ Ð¿ÑÐ¾ÑÐ¾Ð½Ð¾Ð² Ð½Ð° Ð¸Ð·Ð¾ÑÐ¾Ð¿Ðµ 11B Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Î±-ÑÐ°ÑÑÐ¸Ñ Ð´Ð»Ñ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ñ Ð¿Ð¾Ð³Ð»Ð¾ÑÐµÐ½Ð½Ð¾Ð¹ Ð´Ð¾Ð·Ñ Ð² Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ Ð¼Ð¸ÑÐµÐ½Ð¸. ÐÐ°Ð½Ð½Ð°Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð° Ð½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð¸ÑÑÑÑÐµÐ³Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð° ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ 11B (Na2B4O7; Na2B12H11SH) Ð¿ÑÐ¸ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¾ÑÐ¾Ð½Ð°Ð¼Ð¸ Ð½Ð° Ð¿Ð¸ÐºÐµ ÐÑÑÐ³Ð³Ð° ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº. Ð¢ÑÐ¸ ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐµ Ð»Ð¸Ð½Ð¸Ð¸ Ð¿ÑÐµÐ´Ð²Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð¸Ð½ÐºÑÐ±Ð¸ÑÐ¾Ð²Ð°Ð»Ð¸ Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸ÐµÐ¼ 11B Ð¸ Ð¾Ð±Ð»ÑÑÐ°Ð»Ð¸ Ð´Ð¾Ð·Ð°Ð¼Ð¸ 0-8 ÐÑ Ð¿ÑÐ¾ÑÐ¾Ð½Ð°Ð¼Ð¸ Ð½Ð° Ð¿Ð¸ÐºÐµ ÐÑÑÐ³Ð³Ð°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð³Ð°Ð¼Ð¼Ð°-Ð»ÑÑÐ°Ð¼Ð¸. ÐÐ»Ñ ÑÐµÑÑÐ°Ð±Ð¾ÑÐ°ÑÐ° Ð½Ð°ÑÑÐ¸Ñ (Na2B4O7) Ð´Ð¾ÐºÐ°Ð·Ð°Ð½Ð° ÑÐ°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð¸ÑÑÑÑÐ°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ, Ð¾Ð´Ð½Ð°ÐºÐ¾ ÑÐ²ÑÐ·Ð°Ð½Ð½Ð°Ñ Ð½Ðµ Ñ ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÐ°ÐºÑÐ¸ÐµÐ¹, Ð° Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÑÑÐµÐºÑÐ°Ð¼Ð¸, Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÐ¼ÑÐ¼Ð¸ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð¼. ÐÐ»Ñ Ð±Ð¾ÑÐºÐ°Ð¿ÑÐ°ÑÐ° Ð½Ð°ÑÑÐ¸Ñ (Na2B12H11SH) Ð´Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð¾ÑÑÑÑÑÑÐ²Ð¸Ðµ ÑÐ°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÑÑÐµÐºÑÐ°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð³Ð¾Ð²Ð¾ÑÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ 11B Ð½Ðµ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°Ð´Ð¸Ð¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾ÑÐ¾Ð¼ Ð¿ÑÐ¸ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ð¸ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ ÐºÐ»ÐµÑÐ¾Ðº ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¿ÑÐ¾ÑÐ¾Ð½Ð°Ð¼Ð¸ Ð½Ð° Ð¿Ð¸ÐºÐµ ÐÑÑÐ³Ð³Ð° Ð¿Ð¾ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ñ ÑÐ´ÐµÑÐ½Ð¾Ð¹ ÑÐµÐ°ÐºÑÐ¸Ð¸ 11B + p â 3Î±.
description: Proton therapy is used to treat many types of cancer. Due to protonâs unique properties, the tumors that are difficult to reach for surgical procedures could be irradiated by the proton beam. However, there are certain difficulties in the widespread use of proton therapy. The use of radiosensitizers can significantly increase the effectiveness of radiation therapy methods. Boron is already used as a radiosensitizer in boron neutron capture therapy. It was suggested that the same drugs could be used in proton therapy due to the nuclear reaction of protons on the isotope 11B with the formation of Î±-particles to increase the absorbed dose in the tumor target. The given work is devoted to the identification of the radiosensitizing properties of boron compounds on cancerous cells irradiated at the proton Bragg peak. Two human gliomas and one adenocarcinoma were pre-incubated with the boron compound (Na2B4O7, Na2B12H11SH) and irradiated with doses 0-8 Gy at the proton Bragg peak and gamma rays. The radiosensitizing activity was proved for one of the compounds (that turned out to be toxic), but it is not associated with a physical reaction, but with biological effects. The absence of a radiosensitizing effect was proved for the other compound. The data suggest that boron is not a radiosensitizer in proton therapy.