cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
COMBATING THE CRIME OF MONEY LAUNDERING IN INTERNAL AND INTERNATIONAL LAW
Creators: name: ANDRÉA FLORES
name: RODRIGO ALENCAR MACHADO CAMAPUM
Publisher: name: figshare
Year: 2019
Subjects: subject: Law
subject: FOS: Law

description: This article aims to analyze the phenomena that led to the crime of money laundering to expand to the jurisdictions of several states. Addressing the origin of the fight against money laundering, from purely administrative measures, to the criminalization and evolution of legislation to date. Internal legislation, evolution and legislative innovations, as well as the international treaties that have influenced the Brazilian legislation, are analyzed in the present work.
title: Theoretische Grundlagen der Objektorientierung
title: Theoretical foundations of object-oriented programming
titleType: AlternativeTitle
Creators: name: Meurer, Benedikt
Publisher: name: Universitätsbibliothek Siegen
Year: 2007
Subjects: subject: no keine Angabe
subject: Objektorientierung
subject: Programmiersprache
subject: Typsicherheit
subject: Subtyping
subject: Vererbung

description: Im Rahmen dieser Arbeit soll nun eine vollständige Theorie für eine objekt-orientierte Programmiersprache entwickelt werden, welche u.a. die objekt-orientierten Kernkonzepte Datenkapselung (engl. information hiding), Subtyping und Vererbung (häufig als Sub-classing bezeichnet) unterstützt. Als Grundlage für die Betrachtungen dient eine einfache funktionale Programmiersprache, die aus mathematischer Sicht leicht zugänglich ist.
Cattle grazing on reclaimed mine tailings at Highland Valley Copper : a review
Creators: name: Steinke, Daniel
name: Majak, Walter
Publisher: name: The University of British Columbia
Year: 2009

description: Revegetation and sustainable cattle grazing are major objectives in the program for the reclamation of mine tailings at the Highland Valley Copper mine in British Columbia, Canada. Residual molybdenum (Mo) in the tailings is imbibed by vegetation and can accumulate to extremely high levels (> 25 ppm Mo on a dry matter basis). Accordingly, grazing studies were initiated with cattle to determine the feasibility of utilizing the Bethlehem and Highmont tailings sites for livestock production. Molybdenum levels in forages were at least ten times higher at Highmont than at Bethlehem. A total of 262 cow-calf pairs grazed the Bethlehem site for four consecutive years (1994 - 1997) and the Highmont site for five consecutive years (1998 - 2002). Cattle at Bethlehem did not show clinical signs of Mo toxicity or copper deficiency. In contrast, cattle at Highmont showed clinical signs including lameness, diarrhea and haircoat depigmentation. The onset and severity of the affliction appeared to be related, in part, to prevailing moisture conditions, which affected Mo availability in forage. The cattle recovered by the end of each trial and haircoat problems were resolved by the next spring. Preventive measures were attempted using copper supplements that can alleviate Mo toxicity. Copper boluses did not provide adequate protection in 2001 but copper sulphate supplementation in loose salt prevented the onset of clinical signs in 2002.
Microsystem Based on CMOS Multielectrode Array for Extracellular Neural Stimulation and Recording
Creators: Lei, Na
Publisher: name: Columbia University
Year: 2011
Subjects: Engineering
Electrical engineering
Biomedical engineering

description: Neurobiology is constantly in search of new tools and techniques to extract structural and functional information from neural circuitry.  Conventional electrophysiological stimulation and measurement technique such as patch clamping have become the standard techniques for accurate stimulation and recording of electrical activities in neurons. Nevertheless, the number of electrodes that can be introduced into the working chamber is severely limited by the electrode dimension and head stages. Integrating electrodes on chip with complementary metal-oxide-semiconductor (CMOS) technologies enables significantly higher throughput, making analysis on large neural networks possible. This thesis presents the design, characterization, verification, and post-fabrication steps of a microsystem based on a fully integrated high-density multielectrode array (MEA) chip for extracellular stimulation of neural activity. The active MEA is implemented in a standard 0.25 μm CMOS technology with 65,536 non-Faradaic electrodes in an array area of 9 mm2. Each electrode can be configured to produce unique stimulus waveform, delivering a spatial resolution exceeding 12 μm and a temporal resolution exceeding 125 nsec.  The array is integrated with neurons in both dispersed culture and acute thalamocortical slices. Experimental results verify the array functionality by attaining high-resolution stimulation of dispersed primary hippocampal neuronal cultures. Neuronal activity induced from stimulation is detected through changes in real-time calcium fluorescence calibrated with cell-attached patching. Precise electrical stimulation of individual neurons is achieved by optimizing stimulation waveforms, culture preparation, and interface design. The design of a second MEA CMOS chip that integrates extracellular recording with on-chip stimulation is also presented. The chip contains 256x256 non-Faradaic circular electrodes with 14 μm diameter and 20 μm pitch. The active area of the array at 32 mm2 is designed to accommodate entire mouse thalamocortical acute slice with an electrode density of 2000 electrodes per square milimeter. Each electrode integrates with a stimulation pulse generator and a single-transistor transconductance amplifier. The new configuration does not require optical recording and reduces the mechanical setup of the microsystem.
title: 01_0903
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1 of Development and validation of a nomogram for predicting survival of pulmonary invasive mucinous adenocarcinoma based on surveillance, epidemiology, and end results (SEER) database
Creators: name: Wang, Yadong
name: Liu, Jichang
name: Huang, Cuicui
name: Zeng, Yukai
name: Liu, Yong
name: Du, Jiajun
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Figure S1. Flow sheet of eligible patients included in the study. Figure S2. OS for IMA patients stratified by (A) Race, p = 0.772; (B) Marital status, p = 0.226. Figure S3. LCSS for IMA patients stratified by (A) Race, p = 0.959; (B) Marital status, p = 0.267. Figure S4. (A. B) ROC curves for 3- and 5-year OS based on the validation cohort data. The AUC was 0.813 and 0.840, respectively; (C. D) ROC curves for 3- and 5-year LCSS. The AUC was 0.836 and 0.857, respectively. Figure S5. (A. B) Calibration plots for 3- and 5-year OS in the validation cohort; (C. D) Calibration plots for 3- and 5-year LCSS in the validation cohort. Figure S6. Frequency of IMAs in SEER database between 2000 and 2015.
Microtubule Dynamics in Tau-dependent Amyloid Beta Synaptotoxicity
Creators: Qu, Xiaoyi
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Cytology
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Amyloid beta-protein
subject: Microtubules
subject: Alzheimer's disease
subject: Alzheimer's disease--Pathophysiology

description: Alzheimer’s disease is the most common form of dementia among older adults, and directly contributes to the third leading cause of death in the United States. Although amyloid plaques and tau-loaded neurofibrillary tangles have been identified as the main pathological features of Alzheimer’s disease for more than one hundred years, the molecular mechanism is still poorly understood and treatments are limited to palliative care. Oligomeric Amyloid beta plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Amyloid beta toxicity, but the link between the two remains controversial. Since tau is a microtubule associated protein and microtubules are critical for neuronal functions, regulation of dynamic microtubules may serve as the link between Amyloid beta and tau. Here I propose a model in which Amyloid beta can induce changes in MT dynamics in dendrites and axons that are primary to tau hyperphosphorylation, while these MT changes are sufficient to cause tau hyperphosphorylation and necessary for Amyloid beta synaptotoxicity through tau. My thesis work further characterizes mammalian excitatory presynaptic boutons as hotspots for activity-dependent dynamic microtubule nucleation that is required for synaptic transmission during neuronal activation or Amyloid beta-induced neuronal injury through tau.
Microtechnologies for Cardiovascular Tissue Engineering
Creators: Eng, George
Publisher: name: Columbia University
Year: 2013
Subjects: Biomedical engineering

description: Cardiovascular disease is a rising epidemic worldwide, and curative therapies remain elusive. Heart and vascular disease remain some of the hardest to cure due to the limited capacity of the heart to repair itself, necessitating a cell or organ based therapy to cure the inevitable descent into heart failure. Tissue engineering is uniquely poised to significantly alter this disease burden though the fabrication of cardiac and vascular tissues in vitro. However, the challenges for achieving these aims are significant - for cardiac tissues, the therapy must adhere to strict requirements of adequate perfusion and functional integration with the damaged heart. Vascular tissues are required to be amenable to surgical anastomosis while at the same time provide nutrient transport on the cellular level. Recently, a new set of technologies based from the semiconductor industry, have enabled micron level control over the cellular environment and cells themselves and may enable novel approaches to fulfill these tissue engineering requirements. In this dissertation, these microtechnologies will be leveraged to address some of the current obstacles that limit the use of tissue engineering approaches for functional therapy. Specifically, microtechnologies were used to screen the effect of electrical stimulation on the function and maturation of human embryonic stem cell derived cardiomyocytes, which resulted in the ability to program specific individual beating frequencies of the cells while improving contractile function and led to the identification of a channel specific effect for frequency modulation. These technologies were also used to distinguish the vasculogenic potential of different mesenchymal stem cell sources for nascent vessel stabilization, and enabled the development of a powerful hydrogel docking platform with the novel capability to spatially pattern any number of cells, cytokines or drugs on the microscale, while permitting scale up for larger tissue generation without the loss of precision. Finally, these technologies were used to create vascular networks with hierarchical branching patterns that could be implanted and used in vivo fulfilling a major criterion of vascular tissue function - surgical compatibility with microscale architecture for tissue perfusion. Therefore, these microtechnologies support novel interrogation of cell function and enable new methods to engineer cardiovascular tissues.
Cyclic nucleotide‐induced bidirectional long‐term synaptic plasticity in Drosophila mushroom body
Creators: name: Hige, Toshihide
name: Davidson, Andrew M.
name: Yamada, Daichi
Publisher: name: Wiley
Year: 2024

description: Activation of the cAMP pathway is one of the common mechanisms underlying long-term potentiation (LTP). In the Drosophila mushroom body, simultaneous activation of odour-coding Kenyon cells (KCs) and reinforcement-coding dopaminergic neurons activates adenylyl cyclase in KC presynaptic terminals, which is believed to trigger synaptic plasticity underlying olfactory associative learning. However, learning induces long-term depression (LTD) at these synapses, contradicting the universal role of cAMP as a facilitator of transmission. Here, we developed a system to electrophysiologically monitor both short-term and long-term synaptic plasticity at KC output synapses and demonstrated that they are indeed an exception in which activation of the cAMP-protein kinase A pathway induces LTD. Contrary to the prevailing model, our cAMP imaging found no evidence for synergistic action of dopamine and KC activity on cAMP synthesis. Furthermore, we found that forskolin-induced cAMP increase alone was insufficient for plasticity induction; it additionally required simultaneous KC activation to replicate the presynaptic LTD induced by pairing with dopamine. On the other hand, activation of the cGMP pathway paired with KC activation induced slowly developing LTP, proving antagonistic actions of the two second-messenger pathways predicted by behavioural study. Finally, KC subtype-specific interrogation of synapses revealed that different KC subtypes exhibit distinct plasticity duration even among synapses on the same postsynaptic neuron. Thus, our work not only revises the role of cAMP in synaptic plasticity by uncovering the unexpected convergence point of the cAMP pathway and neuronal activity, but also establishes the methods to address physiological mechanisms of synaptic plasticity in this important model. KEY POINTS: Although presynaptic cAMP increase generally facilitates synapses, olfactory associative learning in Drosophila, which depends on dopamine and cAMP signalling genes, induces long-term depression (LTD) at the mushroom body output synapses. By combining electrophysiology, pharmacology and optogenetics, we directly demonstrate that these synapses are an exception where activation of the cAMP-protein kinase A pathway leads to presynaptic LTD. Dopamine- or forskolin-induced cAMP increase alone is not sufficient for LTD induction; neuronal activity, which has been believed to trigger cAMP synthesis in synergy with dopamine input, is required in the downstream pathway of cAMP. In contrast to cAMP, activation of the cGMP pathway paired with neuronal activity induces presynaptic long-term potentiation, which explains behaviourally observed opposing actions of transmitters co-released by dopaminergic neurons. Our work not only revises the role of cAMP in synaptic plasticity, but also provides essential methods to address physiological mechanisms of synaptic plasticity in this important model system.
ADRIFT WORKERS IN THE FRAGMENTED XXI CENTURY COMPANY: FUNDAMENTALS TO AN EMANCIPATORY POLICY
Creators: name: DANIEL AMIN FERRAZ
name: GERARDO ALVES LIMA FILHO
Publisher: name: figshare
Year: 2019
Subjects: subject: Law
subject: FOS: Law

description: This article deals with the transformations and main consequences of the XXI century business and labor worlds. In this sense, it initially tries to identify the main tendencies and characteristics of this possible new interaction phase of the economic players and trying to explore the risks resulting to the vulnerable group of the workers. Then, this set of changes is examined at the legislative level, analyzing its compatibility or incompatibility with the social protection system of the 1988 Federal Constitution. Later, Ronald Dworkin’s integrity theory is applied to verify if the alterations are accord to the principles of equal consideration and respect to all citizens, and the autonomy of each citizen to choose the aspects of their own life. Last, suggestions are made to ensure a model that promotes the worker’s emancipation as a subject that offers its potentialities to society as a manifestation of their dignity in the labor world.
Additional file 2 of Development and validation of a nomogram for predicting survival of pulmonary invasive mucinous adenocarcinoma based on surveillance, epidemiology, and end results (SEER) database
Creators: name: Wang, Yadong
name: Liu, Jichang
name: Huang, Cuicui
name: Zeng, Yukai
name: Liu, Yong
name: Du, Jiajun
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Table S1. Characteristics of the training and validation cohort.
On Sasakian-Einstein Geometry
Creators: name: Boyer, Charles P.
name: Galicki, Krzysztof
Publisher: name: arXiv
Year: 1998
Subjects: subject: Differential Geometry (math.DG)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We discuss Sasakian-Einstein geometry under a quasi-regularity assumption. It is shown that the space of all quasi-regular Sasakian-Einstein orbifolds has a natural multiplication on it. Furthermore, necessary and sufficient conditions are given for the `product' of two Sasakian-Einstein manifolds to be a smooth Sasakian-Einstein manifold. Using spectral sequence arguments we work out the cohomology ring in many cases of interest. This type of geometry has recently become of interest in the physics of supersymmetric conformal field theories.
description: 31 pages, revised and corrected version
Microtubules, Acetylation, and MEC-3 Regulated Genes in C. Elegans Mechanosensations
Creators: Keller, Charles Clifford
Publisher: name: Columbia University
Year: 2011
Subjects: subject: Biology
subject: Neurosciences
subject: FOS: Clinical medicine

description: The ability to transform physical energies from internal and external environments into neuronal signals underlies the senses of hearing and touch as well as many aspects of body self-awareness. The small soil dwelling nematode Caenorhabditis elegans has proven to be a useful system in which to study neuronal mechanosensation and the development of specialized neuronal subtypes. Response to gentle body touch in C. elegans is mediated by the six Touch Receptor Neurons (TRNs). TRN cell fate is specified by the LIM-Homeodomain transcription factor MEC-3. Gene expression profiling has revealed a set of putatively MEC-3 dependant transcripts, which may represent the set of genes necessary to establish a TRN fate. I characterized this set of putatively MEC-3 regulated transcripts confirming the MEC-3 dependant expression of several previously unrecognized MEC-3 targets providing insight into TRN development and function and identifying the CCT chaperonin complex as being needed for TRN function. LIM-HD transcription factors play important developmental roles across phyla particularly in neurons. The data presented in this thesis provide insight into LIM-HD function in general and provide targets for further research in C. elegans TRNs as well as neurons from higher organisms. Microtubules (MTs) play crucial roles in the majority of eukaryotic cells where they are required for cell division, intracellular transport, morphological stability and a variety of other functions. The TRNs of C. elegans are characterized by unique large-diameter, heavily acetylated microtubules (MTs), which are required for mechanosensation. The TRNs thus present a valuable model for the study of neuronal MTs and MT acetylation, which is a poorly understood but widespread MT modification particularly in post-mitotic neurons. I employed TRN-specific RNAi to identify MT-associated proteins not previously known to be involved with mechanosensation including the CCPP-1 tubulin deglutamylase, the C. elegans homolog of the MT severing enzyme katanin, and several other proteins. I also shed light on the significance of Ã¡-tubulin acetylation by investigating the acetyltransferases responsible. MEC-17 and ATAT-2 are Ã¡-tubulin acetyltransferases found in the TRNs, which illustrate mechanosensory defects when mutated. I found that mec-17 mutants exhibit a drastic decrease in TRN MT number as well as an elimination of the unknown electron-dense material found in the lumen of TRN MTs and other MTs across phyla. I also found that eliminating MEC-17 activity changed TRN morphology, resulting in ectopic sprouting and process growth. These results suggest that acetyltransferase activity is required for TRN MT integrity, mechanosensory function, and the maintenance of TRN morphology.
Development of a site-specific water quality objective for copper for a post-closure mine site discharge
Creators: name: Martin, Alan J.
name: Goldblatt, Robert
name: Hiller, Dave
Publisher: name: The University of British Columbia
Year: 2009

description: Detour Lake Mine, located 200 km northeast of Timmins, Ontario, operated from 1983 to 1999 using a combination of open pit and underground mining methods. As part of the historic tailings circuit, East Lake served as a tertiary polishing pond for gold mill effluents prior to final discharge to the receiving environment. The discharge from East Lake serves as the final point of discharge for the mine site, with copper concentrations ranging from 40 to 150 µg/L. As part of the overall closure management, Placer Dome Inc. has initiated a program to develop a site-specific water quality objective (WQO) for dissolved copper at East Lake discharge. WQO generation entailed the assessment of three components: 1) the assimilative capacity of the receiving environment downstream of East Lake, with consideration to dilution, Cu speciation and complexation capacity; 2) toxicity data, including chronic and acute toxicity testwork conducted on water collected at the East Lake discharge and in the downstream environment; and 3) use of the water-effect ration (WER) procedure as outlined by the government of Canada and the USEPA. Based on the testwork, a preliminary site-specific water quality objective for dissolved copper ranging from 34 to 75 µg/L has been proposed. The range in WQO values can be explained by temporal variability in Cu complexation capacity, which in turn can be related to variations in both the quantity and quality of dissolved organic carbon.
THE LEGITIMACY OF JUDICIAL ACTIVISM IN THE HOMAFFATIVE FAMILY FROM DIRECT ACTION OF UNCONSTITUTIONALITY 4.277/2011
Creators: name: VALÉRIA SILVA GALDINO GALDINO
name: CAIO EDUARDO COSTA CAZELATTO
name: LUIZ AUGUSTO RUFFO
Publisher: name: figshare
Year: 2019
Subjects: subject: Law
subject: FOS: Law

description: A questioning about the legitimacy of the decision made by the Federal Supreme Court, resulting from the division of competences between the powers of the Union, was carried out. The methodology used was that of bibliographic research, based on the criticisms raised by Lênio Streck about the performance of the Judiciary, characterizing it as a judicial activism to be fought, reflecting on the concrete motivations that make the activism come to take place, using the considerations of Rachel Nigro, who proposes a revision of the concepts of democracy, making defense of legitimate and necessary activism. thus, it acknowledges the negatives of judicial activism, but also acknowledges the denials of non-protection of Fundamental Rights in the name of a restricted application of the constitutional text. this, therefore, leaving homoaffective families to the margin of what is their right, waiting for legislative goodwill, goes against what is, in fact, democratic and constitutional. the symbolic burden that a coherent normative production of the factual aspects of homoaffective families would bring to the juridical and social security of such a group is also punctuated.
An Asymptotic Formula for the Number of Smooth Values of a Polynomial
Creators: name: Martin, Greg
Publisher: name: arXiv
Year: 1999
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11N32, 11N25

description: Although we expect to find many smooth numbers (i.e., numbers with no large prime factors) among the values taken by a polynomial with integer coefficients, it is unclear what the asymptotic number of such smooth values should be; this is in contrast to the related problem of counting the number of prime values of a polynomial, for which Bateman and Horn published a conjectured asymptotic formula that is widely believed to be true. We discuss how to employ the Bateman-Horn conjecture to derive an asymptotic formula for the number of smooth values of a polynomial, with the smoothness parameter in a non-trivial range. This conditional result provides a believable heuristic for the number of smooth integers among all values {F(n)}, and also among the values {F(p)} on prime arguments only.
description: 57 pages. Revised version - an appendix has been added and some other material rewritten slightly
Enhancement of antiferromagnetic magnon-magnon entanglement by cavity cooling
Creators: name: Yuan, H. Y.
name: Zheng, Shasha
name: Ficek, Zbigniew
name: He, Q. Y.
name: Yung, Man-Hong
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Magnon-photon coupling has been experimentally realized inside a cavity and the emerging field known as cavity spintronics has attracted significant attention for its potential docking with quantum information science. However, one seldom knows whether this coupling implies an entanglement state among magnons and photons or not, which is crucial for its usage in quantum information. Here we study the entanglement properties among magnons and photons in an antiferromagnet-light system and find that the entanglement between magnon and photon is nearly zero while the magnon-magnon entanglement is very strong and it can be even further enhanced through the coupling with the cavity photons. The maximum enhancement occurs when the antiferromagnet reaches resonant with the light. The essential physics can be well understood within the picture of cavity induced cooling of magnon-magnon state near its joint vacuum with stronger entanglement. Our results are significant to extend the cavity spintronics to quantum manipulation and further provide an alternate to manipulate the deep strong correlations of continuous variable entanglement with a generic stable condition and easy tunability.
description: 5 pages, 3 figures
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Creators: name: Corti, Davide
name: Stewart, Cameron
name: Park, Young-Jun
name: Baric, Ralph
name: Veesler, David
name: Asarnow, Daniel
name: Treichel, Catherine
name: Schäfer, Alexandra
name: Sprouse, Kaitlin R.
name: Leaf, Elizabeth M.
name: Lee, Jimin
name: King, Neil P.
name: Powers, John M.
Publisher: name: Springer Nature
Year: 2024

description: Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S2 subunit, which folds as a spring-loaded fusion machinery. We describe a strategy for prefusion-stabilization and high yield recombinant production of SARS-CoV-2 S2 trimers with native structure and antigenicity. We demonstrate that our design strategy is broadly generalizable to sarbecoviruses, as exemplified with the SARS-CoV-1 (clade 1a) and PRD-0038 (clade 3) S2 subunits. Immunization of mice with a prefusion-stabilized SARS-CoV-2 S2 trimer elicits broadly reactive sarbecovirus antibodies and neutralizing antibody titers of comparable magnitude against Wuhan-Hu-1 and the immune evasive XBB.1.5 variant. Vaccinated mice were protected from weight loss and disease upon challenge with XBB.1.5, providing proof-of-principle for fusion machinery sarbecovirus vaccines.
MPEC 2025-G118 : 2020 RR
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Monte Carlo Renormalization Group for Entanglement Percolation
Creators: name: Balcan, Duygu
name: Erzan, Ayse
Publisher: name: arXiv
Year: 2002
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We use a large cell Monte Carlo Renormalization procedure, to compute the critical exponents of a system of growing linear polymers. We simulate the growth of non-intersecting chains in large MC cells. Dense regions where chains get in each others' way, give rise to connected clusters under coarse graining. At each time step, the fraction of occupied bonds is determined in both the original and the coarse grained configurations, and averaged over many realizations. Our results for the fractal dimension on three dimensional lattices are consistent with the percolation value.
description: 5 pages, 5 figures
Trichodina acuta Lom 1961
Creators: name: Drobiniak, O.
name: Kutsokon, Yu.
name: Kvach, Yu.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Chromista
Ciliophora
Oligohymenophorea
Peritrichida
Trichodinidae
Trichodina
Trichodina acuta

description: Trichodina acuta Lom, 1961 (fig. 2, a)
L o c a l i t y. Lake Berizka in Kyiv (table 1).
D e s c r i p t i o n. Cell diameter 76.7 (1), diameter of adhesive disc 61.8 (1). Denticle number 21 (1). Width of border membrane 5.4 (1), diameter of denticle ring 53.4 (1), number of radial pins per denticle 5 (1). Central zone of the denticle ring is clear and evenly impregnated by silver. Blade sickle-shaped and broad, filling most of space between y-axis; Tangent point sharp, with distal margin slightly higher or at same level as tangent point. Distal surface with slight slope towards prominent blade apex that almost touches or extends only slightly beyond y-axis. Posterior blade margin forming deep curve, with deepest point lower than blade apex. Blade apophysis strongly developed and angular, coinciding with well developed posterior projection in previous denticle; length of blade 7.1 (1). Rays are broad and tapering downward, little recurved, but are flush with blades, length of rays is 8.3 (1). Central parts squat and well developed, extending slightly more than halfway towards y–1–axis.
description: Published as part of Drobiniak, O., Kutsokon, Yu. & Kvach, Yu., 2014, Trichodinids (Ciliophora, Peritrichia) Of Perccottus Glenii (Actinopterygii, Odontobutidae) In Three Ukrainian Rivers, pp. 231-238 in Vestnik Zoologii 48 (3) on page 233, DOI: 10.2478/vzoo-2014-0026, http://zenodo.org/record/6453044
Additional file 1 of Are need for affect and cognition culture dependent? Implications for global public health campaigns: a cross-sectional study
Creators: name: Zhang, Min
name: Zhu, Bei
name: Yuan, Chunlan
name: Zhao, Chao
name: Wang, Jiaofeng
name: Ruan, Qingwei
name: Han, Chao
name: Bao, Zhijun
name: Chen, Jie
name: Arceneaux, Kevin ( Vin)
name: Wielen, Ryan Vander
name: Siegle, Greg J.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: Appendix The Chinese version of the Need for Affect-Short Scale. The Chinese translation of the 10-item NFA scale.
title: Математика. Ч. 1. Степенная и показательная функции
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2025

description: Первая часть практикума содержит краткие теоретические сведения, понятия, свойства, графики степенной и показательной функций, решение типовых уравнений, неравенств и систем, содержащих степенную (в том числе и иррациональные) и показательную функции. Подготовлен в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Практикум предназначен для студентов всех профессий и специальностей среднего профессионального образованию на базе основного общего образования, изучающих темы «Повторение», «Степенная функция», «Показательная функция» в рамках учебной дисциплины «Математика».
The Amberley Castle panels and a drawing by William Henry Brooke.
Creators: name: Coke, Karen
Publisher: name: Archaeology Data Service
Year: 2008

description: Sussex Archaeological Collections, 145, 137-152
description: The article begins with a documentary history of Lambert Barnard's Amberley Castle `worthies', painted for Robert Sherburne, Bishop of Chichester in the early-sixteenth century, and their origins. This is followed by a discussion of their subject; of a drawing of 1820 by William Henry Brooke, which provides valuable historical evidence of their original form; and of the importance of their combined survival.
Tensor-Tensor Theory of Gravitation
Creators: name: Gogberashvili, Merab
Publisher: name: arXiv
Year: 1996
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the standard gauge theory of Poincaré group, realizing as a subgroup of $GL(5. R)$. The main problem of this theory was appearing of the fields connected with non-Lorentz symmetries, whose physical sense was unclear. In this paper we treat the gravitation as a Higgs-Goldstone field, and the translation gauge field as a new tensor field. The effective metric tensor in this case is hybrid of two tensor fields. In the linear approximation the massive translation gauge field can give the Yukava type correction to the Newtons potential. Also outer potentials of a sphere and ball of the same mass are different in this case. Corrections to the standard Einshtein post Newtonian formulas of the light deflection and radar echo delay is obtained. The string like solution of the nonlinear equations of the translation gauge fields is found. This objects can results a Aharonov-Bohm type effect even for the spinless particles. They can provide density fluctuations in the early universe, necessary for galaxy formations. The spherically symmetric solution of the theory is found. The translation gauge field lead to existence of a impenetrable for the matter singular surface inside the Schwarzschild sphere, which can prevent gravitational collapse of a massive body.
description: 22 pages, LaTex, no figures, no macros
Middle School Learning, Academic Emotions and Engagement as Precursors to College Attendance
Creators: San Pedro, Maria Ofelia Clarissa Zapanta
Publisher: name: Columbia University
Year: 2016
Subjects: College attendance--Forecasting
High school students--Psychology
Middle school students--Psychology
Education
Cognitive psychology
Educational technology

description: This dissertation research focuses on assessing student behavior, academic emotions, and knowledge within a middle school online learning environment, and analyzing potential effects on students’ interests and choices related to decisions about going to college. Using students’ longitudinal data ranging from their middle school, to high school, to postsecondary years, this dissertation uses quantitative methodologies to investigate antecedents to college attendance that occur as early as middle school. The dissertation asks whether student behavior, academic emotions, and learning as early as middle school can be predictive of college attendance years later. This is investigated by developing predictive and structural models of said outcomes, using assessments of learning, emotions and engagement from student interaction data from an online learning environment they used in their middle school curriculum. The same middle school factors are also assessed with self-report measures of course choices, interests in college majors and careers formed when they were in high school. The dissertation then evaluates how student choices and interests in high school can mediate between the educational experiences students have during middle school and their eventual college attendance, to give a fuller illustration of the cognitive and non-cognitive mechanisms that students may experience throughout varied periods in school. Such understanding may provide educators with actionable information about a students’ in-depth experiences and trajectories within the college pipeline.
Intraductal Carcinoma of the Prostate versus Simulants: A Differential Diagnosis Growing in Clinical Impact
Creators: name: Smith, Steven Christopher
name: Wobker, Sara E.
Publisher: name: MDPI
Year: 2024

description: Despite its first recognition even longer ago, in the past nearly 20 years, intraductal carcinoma of the prostate has become a standard histopathologic reporting parameter conveying a strong negative prognostic factor for prostatic adenocarcinoma. When seen at biopsy, intraductal carcinoma of the prostate is associated with risk for aggressive prostatectomy outcomes, including frequently high-grade, high-stage, high-volume disease, with increased risk for recurrence and progression. Multiple organizations, including the uropathology subspecialty societies to the World Health Organization, recognize and recommend reporting the presence of intraductal carcinoma, whether sampled in "pure" form or present with concomitant invasive adenocarcinoma. Moreover, emerging scholarship relates intraductal carcinoma to higher prevalence of homologous recombination repair deficiency mutations in prostatic adenocarcinoma, whether somatic or germline, which serve as indications for approved targeted therapies. Taken together, this is a diagnosis for the histopathologist not to miss. In view of these elevated stakes and the opportunity to further precision medicine, this review details neoplastic and non-neoplastic simulants in the differential diagnosis of intraductal carcinoma of the prostate.
Determinant Structure of the Rational Solutions for the Painlevé IV Equation
Creators: name: Kajiwara, Kenji
name: Ohta, Yasuhiro
Publisher: name: arXiv
Year: 1997
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: Rational solutions for the Painlevé IV equation are investigated by Hirota bilinear formalism. It is shown that the solutions in one hierarchy are expressed by 3-reduced Schur functions, and those in another two hierarchies by Casorati determinant of the Hermite polynomials, or by special case of the Schur polynomials.
description: 19 pages, Latex, using theorem.sty
Direct calculation of time varying Aharonov Bohm effect
Creators: name: Choudhury, S. Rai
name: Mahajan, Shobhit
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Aharonov-Bohm effect (ABE) for steady magnetic fields is a well known phenomenon. However, if the current in the infinite solenoid that creates the magnetic field is time-dependent, that is in the presence of both magnetic and electric fields, there is no agreement whether the effect would be present. In this note, we try to investigate time varying ABE by a direct calculation in a set-up with a weak time dependent magnetic field. We find that the electric field arising out of the time-varying magnetic field in the path of the electrons does not enter the action integral but only changes the path of the electron from the source to the slits and then on to the detector. We find a frequency dependent AB phase shift. At low frequencies the result smoothly approaches the one for a constant field as the frequency tends towards zero. On the other hand, for high frequencies such that the AB-phase induced in the path of the wave packet oscillates rapidly, the net effect will be very small which is borne out by our results.
description: 10 pages, 2 figures
SU(3) Clebsch-Gordan Coefficients
Creators: name: Grigorescu, Marius
Publisher: name: arXiv
Year: 2000
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Group Theory (math.GR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The paper contains the derivation of a general set of recurrence formulas for the calculus of the SU(3) Clebsch-Gordan coefficients. The first six sections are introductory, presenting the notations and placing SU(3) in the framework of the general group theory. The following eight sections are devoted to the detailed treatment of the carrier spaces of the irreducible representations and their direct product.
description: 57 pages, LaTex, 9 figures in 2 jpg files
On the invariant spectrum of $S^1$-invariant metrics on $S^2$
Creators: name: Abreu, Miguel
name: Freitas, Pedro
Publisher: name: arXiv
Year: 1999
Subjects: subject: Spectral Theory (math.SP)
subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 35P15 (primary); 58J50, 53D20 (secondary)

description: A theorem of J. Hersch (1970) states that for any smooth metric on $S^2$, with total area equal to $4π$, the first nonzero eigenvalue of the Laplace operator acting on functions is less than or equal to 2 (this being the value for the standard round metric). For metrics invariant under the standard $S^1$-action on $S^2$, one can restrict the Laplace operator to the subspace of $S^1$-invariant functions and consider its spectrum there. The corresponding eigenvalues will be called invariant eigenvalues, and the purpose of this paper is to analyse its possible values. We first show that there is no general analogue of Hersch's theorem, by exhibiting explicit families of $S^1$-invariant metrics with total area $4π$ where the first invariant eigenvalue ranges through any value between 0 and $\infty$. We then restrict ourselves to $S^1$-invariant metrics that can be embedded in ${\bf R}^3$ as surfaces of revolution. For this subclass we are able to provide optimal upper bounds for all invariant eigenvalues. As a consequence, we obtain an analogue of Hersch's theorem with an optimal upper bound (greater than 2 and geometrically interesting). This subclass of metrics on $S^2$ includes all $S^1$-invariant metrics with non-negative Gauss curvature. One of the key ideas in the proofs of these results comes from symplectic geometry, and amounts to the use of the moment map of the $S^1$-action as a coordinate function on $S^2$.
description: 18 pages, minor changes
Trichodina perforata Lom, Golemansky et Grupcheva 1976
Creators: name: Drobiniak, O.
name: Kutsokon, Yu.
name: Kvach, Yu.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Chromista
Ciliophora
Oligohymenophorea
Peritrichida
Trichodinidae
Trichodina
Trichodina perforata

description: Trichodina perforata Lom, Golemansky et Grupcheva, 1976 (fig. 2, f)
L o c a l i t y. Lake Berizka (table 1).
D e s c r i p t i o n. Cell diameter 35.3 (1), diameter of adhesive disc 31.3 (1). Denticle number 28 (1). Width of border membrane 2.7 (1), diameter of denticle ring 19.6 (1). Central zone of the denticle ring is clear and evenly impregnated by silver. Blade as plates, expanding to broad upper part with sharpened apex, length of blade 4.0 (1). Rays thin, filiform, curved forward, length of ray 5.0 (1).
description: Published as part of Drobiniak, O., Kutsokon, Yu. & Kvach, Yu., 2014, Trichodinids (Ciliophora, Peritrichia) Of Perccottus Glenii (Actinopterygii, Odontobutidae) In Three Ukrainian Rivers, pp. 231-238 in Vestnik Zoologii 48 (3) on page 235, DOI: 10.2478/vzoo-2014-0026, http://zenodo.org/record/6453044
Quantum Gauged Neural Network: U(1) Gauge Theory
Creators: name: Fujita, Yukari
name: Matsui, Tetsuo
Publisher: name: arXiv
Year: 2002
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: High Energy Physics - Lattice (hep-lat)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A quantum model of neural network is introduced and its phase structure is examined. The model is an extension of the classical Z(2) gauged neural network of learning and recalling to a quantum model by replacing the Z(2) variables, $S_i = \pm1$ of neurons and $J_{ij} =\pm1$ of synaptic connections, to the U(1) phase variables, $S_i = \exp(iϕ_i)$ and $J_{ij} = \exp(iθ_{ij}) $. These U(1) variables describe the phase parts of the wave functions (local order parameters) of neurons and synaptic connections. The model takes the form similar to the U(1) Higgs lattice gauge theory, the continuum limit of which is the well known Ginzburg-Landau theory of superconductivity. Its current may describe the flow of electric voltage along axons and chemical materials transfered via synaptic connections. The phase structure of the model at finite temperatures is examined by the mean-field theory, and Coulomb, Higgs and confinement phases are obtained. By comparing with the result of the Z(2) model, the quantum effects is shown to weaken the ability of learning and recalling.
description: 8 pages, 4 figures: Revised with a new reference