cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fantasy in the domestic space
Creators: name: Tiboni-Craft, Silvia
Publisher: name: No Publisher Supplied
Year: 2015

description: In my dissertation, I intend to explore the domestic space in which women were segregated. The analysis of the representation of the domestic space will lead to a peculiar aspect of it: the definition of a fantastic space within the domestic space. The critical analysis will be restricted to Italian women writers between the end of the 19th century and the beginning of the 20th century, no later than the immediate aftermath of WWI. This project will be divided into three chapters.   In the first Chapter I give a general introduction to women's situation right after the Unification of Italy (1961) addressing particularly the necessity to kill the image of the Angel of the House. After this general introduction, I discuss the theoretical approaches that I use during my analysis of the literary texts. Butler’s theory on performative gender and Cixous’s idea of stolen bodies will help me to demonstrate the necessity for women to participate in the process of doing and undoing their own selves to start the re-appropriation of their own bodies stolen by the patriarchal system. In addition to that I also address De Certau and Bachelard’s sociological approaches.   In the second chapter I start the analysis of the fantastic space with what I define as fantasma, which is the space that women create within the domestic walls in order to survive the domestic tyranny. Through the literary works of Contessa Lara, Marchesa Colombi, Matilde Serao, and Neera, I argue that the fantastic space, and not the house, is the intimate space for women where they experience life and their real selves. The fantasma becomes the tactic to deal with the house that represents the strategy ruled by the patriarchy.   In the third chapter, I continue my analysis of the fantastic space through the narratives of Maria Messina and Sibilla Aleramo, showing how the fantasma slowly becomes a more defined space in the first two decades of the 20th century, even though women were still subdued by male power.
Pseudocomeron luzonicum Breuning 1963
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Pseudocomeron
Pseudocomeron luzonicum

description: 77. Pseudocomeron luzonicum Breuning, 1963
Philippines: Luzon isl., Ifugao, Banaue, 09.2015 (2, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 245, DOI: 10.5281/zenodo.10905476
The ludic imagination
Creators: name: Trammell, Aaron
Publisher: name: No Publisher Supplied
Year: 2015

description: How have the ways we imagine and understand games changed since World War II? Play and games, although inextricably connected, have come to mean quite different things in the early twenty-first century popular culture, and I argue that this change is a cultural product of The Cold War. Today, games are described as products, systems, and even rituals. It is assumed that all games have rules, and these rules are shared through code, manuals, and sometimes oral tradition. Whereas games are systems, play is the embodied phenomenon associated with navigating such systems. Play relates specifically to bodies, and is often—though not necessarily always—connected to games. The nature of games and play is generally agreed upon in both popular discourse and by game studies scholarship.  People play games, people play with each other, and the essence of play cannot be reduced to any one product, container, system of rules, or even social ritual. Rules may contort the dynamics of play, but they cannot define the essence of the phenomenon. Building on these distinctions, this dissertation claims, first, that our definitions of games and play are discursively contingent. Second, it develops this point by showing how in the latter half of the twentieth century, games began to be explicitly valorized over play. Games are typically seen as valuable, productive, and potentially transformative, while play is normally associated with leisurely, childish, and chaotic behavior. Third, alongside the valorization of games over play there has emerged a discourse that this dissertation terms the ludic imagination in which “truth” is conflated with quantitative and competitive logics. The ludic imagination contributes to other studies of the Cold War by focusing on the value placed on rationality as well as the affects of isolation and fear that characterize the era’s popular culture and military policy.      I use correspondence, internal reports and memos from the RAND Corporation Archive and The MIT Center for International Studies, as well as hobby publications and trade publications from The Ray Browne Popular Culture Archive and the Dragon Magazine CD-ROM Archive in order to reveal a historical arc that connects military ideology around games and play to popular culture. This arc includes documentation from the RAND Corporation, correspondence within a grassroots network of gamers that included play-by-mail Diplomacy hobbyists, and the design notes of Dungeons & Dragons players. Through these primary sources, I show how networks of military elites at the RAND Corporation overlapped with networks of grassroots hobbyists and together imagined the intersection of games and play. This reading evaluates the limits of these terms by considering how racism, sexism, and homophobia collude with the quantitative and essentialist worldview of military logistics. Here I evaluate the indebtedness of the ludic imagination to a reductionist and pragmatist military ideology and consider what potentials exist to play with its future definition.
Gaultheria (sect. Chiogenopsis) (ser. Trichophyllae) Airy Shaw 1941
Creators: name: Fritsch, Peter W.
name: Armstrong, Kate E.
name: Aung, Mu Mu
name: Fujikawa, Kazumi
name: Lu, Lu
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Ericaceae
Gaultheria

description: Classification — Gaultheria sect. Chiogenopsis ser. Trichophyllae.
Phylogenetic placement — Trichophyllae clade.
Literature — Airy Shaw 1941, Kress et al. 2003, Fang & Stevens 2005, Fritsch et al. 2008, Fritsch & Lu 2020).
Myanmar specimens — Kachin: Putao District, Putao Township, Hponganrazi Wildlife Sanctuary, between Ye Khe Sap and Hponganrazi summit, 3,176 m, 27°30’52.6”N, 96°56’30.5”E, 22 October 2016, K. Armstrong et al. 2004 (E!, NY 02653289!, RAF!); [Putao District, Khaunglanphu Township,] Chawchi Pass, 11,000 ft, 2 July 1920, R.J. Farrer 1676 (E E00231071!); ditto, 12,500 ft, 18 July 1920, R.J. Farrer 1737 (E E00231073!); [Putao District, Nawngmun Township, Hkakaborazi National Park,] Advance Base Seingkhu Wang, 10,000 ft, 6 April 1924, F. Kingdon-Ward 6845 (K [2 sheets]!); [Putao District, Nawngmun Township, Hkakaborazi National Park,] sources of the Irrawaddy, Adung Valley, 28°20’N, 97°40’E, 10,000–11,000 ft, 10 June 1931, F. Kingdon-Ward 9628 (BM BM013823048!*).
description: Published as part of Fritsch, Peter W., Armstrong, Kate E., Aung, Mu Mu, Fujikawa, Kazumi & Lu, Lu, 2023, Gaultheria (Ericaceae) of Myanmar: an updated species list for the country, a new species, and a new species combination, pp. 37-61 in Phytotaxa 595 (1) on page 43, DOI: 10.11646/phytotaxa.595.1.3, http://zenodo.org/record/7889451
Effect of hydroxylated polymethoxyflavones and acetylated polymethoxyflavones on adipogenesis in vivo and in vitro
Creators: name: Tung, Yen-Chen
Publisher: name: No Publisher Supplied
Year: 2015

description: Excess energy is a major cause of obesity and it can increase the number and size of adipocytes, eventually expanding the adipose tissue. Adipose tissue can be deposited in the intra-abdominal area and it affects the function of other organs, such as the liver, pancreas, and skeletal muscle, therefore, it is a risk factor related to liver disease and type 2 diabetes. Diet modification and the inhibition of the cause of obesity-related molecular mechanisms could be solutions for controlling the expansion of adipose mass and decreasing the prevalence of obesity. Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones (HPMFs) such as nobiletin, tangeretin, 5-demethyltangeretin, and 5-demethylnobiletin are unique flavonoids that almost exclusively exist in the peel of the citrus genus and have many health-beneficial effects. However, their lipophilic structure and characteristics give them poor aqueous solubility and low oral bioavailability.   In the current research, we prepared 5-demethyltangeretin (5-OH-Tan), 5-demethylnobiletin (5-OH-Nob), 5-acetyloxy-6,7,8,4′-tetramethoxyflavone(5-Ac-Tan), and 5-acetyloxy-6,7,8,3′,4′-pentamethoxyflavone (5-Ac-Nob) through chemical modification from nobiletin and tangeretin. Firstly, we found that 5-Ac-Nob had better anti-adipogenesis activity than 5-OH-Nob, 5-OH-Tan, and its anti-adipogenesis ability by increased the phosphorylated-LKB1 and AMPKα protein levels and decreases the transcriptional factor SREBP-1 and lipogenesis-related enzyme fatty acid synthase protein levels in a 3T3-L1 preadipocyte model. Therefore, we further investigated the anti-adipogenesis effect of 5-Ac-Nob by using a diet with 45% calories from fat to induce obesity in C57BL/6J male mice. We found that mice fed with 5-Ac-Nob had lower body weight; intra-abdominal fat, plasma and liver triacylglycerol levels, and plasma cholesterol level and it had potential to prevent fatty liver by increased phosphorylated-LKB1 and AMPKα protein levels and increased the level of a lipogenesis-related enzyme, an inactive form of phosphorylated acetyl-CoA carboxylase protein, in the liver. In addition, we also found that 5-OH-Nob could be a metabolite hydrolyzed from 5-Ac-Nob in plasma when the mouse were administered with 100 mg/ kg bw of 5-Ac-Nob by oral gavage. All these results showed that 5-Ac-Nob could be a 5-OH-Nob prodrug to alleviate lipid accumulation by activated AMPKα and then affect lipid synthesis in vivo and in vitro.
Pseudodoliops elegans subsp. apoensis Barševskis 2019
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Pseudodoliops
Pseudodoliops elegans
Pseudodoliops elegans apoensis

description: 78. Pseudodoliops elegans apoensis Barševskis, 2019
Philippines: Mindanao isl., Lanao del Sur, Bayog, 03.2021 (1, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on pages 245-246, DOI: 10.5281/zenodo.10905476
title: Minimal surfaces and surfaces of constant mean curvature in homogeneous spaces
Creators: name: Käse, Philipp
Publisher: name: UNSPECIFIED
Year: 2025

description: We give a classification of surfaces of constant mean curvature in homogeneous 3-manifolds, which are invariant under rotational screw motions. These surfaces are natural generalizations of the well-known Delaunay surfaces. Our result is the first unified classification in U+1D53C(U+03BA,U+03C4). In particular, we show that some of the previous classifications were incomplete, because there are two new surface types arise beside the generalized Delaunay surfaces: inverted nodoids and so-called tubes. We also present a complete picture of the corresponding moduli space. Furthermore, we prove an extensive existence result for screw motion tubes and study global geometric properties of continuous 1-parameter families such as embeddedness and foliation.
Additional file 2: Table S2. of Physical activity and overweight/obesity among Malaysian adults: findings from the 2015 National Health and morbidity survey (NHMS)
Creators: name: Chan, Ying
name: Lim, Kuang
name: Teh, Chien
name: Kee, Chee
name: Siew Cheong
name: Khoo, Yi
name: Azli Baharudin
name: Miaw Ling
name: Mohd Omar
name: Ahmad, Noor
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Mean values of physical activity (MET-hours/week) for men and women according to BMI status from the 2015 NHMS. These data show the mean MET-hours/week of physical activity between normal-weight and overweight/obese individuals. The data were analyzed for men and women separately. (DOC 60Â kb)
A MODERN VIEW ON THE PROBLEM OF DIAGNOSTICS OF PATIENTS WITH ANGIOFIBROMA OF THE NASOPHARYNX BY IDENTIFYING POLYMORPHISM OF THE GSTM 1 GENE
Creators: name: Kazimov, Bekzod
name: Rakhmanova, Luiza
name: Turaeva, Rushana
name: Khamrakulova, Nargiza
Publisher: name: Zenodo
Year: 2025

description: Nasopharyngeal angiofibroma is a rare but potentially dangerous disease that requires accurate diagnosis and effective treatment methods. Current approaches to diagnosis are based primarily on visual and morphological methods, but the use of molecular markers, such as GSTM1 gene polymorphism, opens up new perspectives in this area. Genes involved in xenobiotic metabolism and antioxidant defense influence the development of tumor diseases, including angiofibroma. GSTM1 gene polymorphism, in particular its deletion, may be associated with an increased risk of tumor development, which emphasizes its importance as a diagnostic marker. The article provides an overview of existing diagnostic methods for nasopharyngeal angiofibroma and discusses the possibilities of using GSTM1 polymorphism to improve prognosis, individualize treatment, and increase the effectiveness of therapy. It is recommended to further study the role of this genetic marker in the pathogenesis of the disease and introduce it into clinical practice for more accurate diagnostics and development of personalized approaches to treatment.
Trichomyia (Brachitrichomyia) Bravo & Araújo
Creators: name: Araújo, Maíra Xavier
name: Bravo, Freddy
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Trichomyia
Trichomyia inermis

description: Subgenus Brachitrichomyia Bravo & Araújo
Brachitrichomyia Bravo & Araújo, 2013: 330.
Type species: Trichomyia inermis Barretto, 1954, by original designation.
Comments. Males of Brachitrichomyia are recognized because the gonocoxites are projected dorsally, each one with elongated posterior arm, 1.0–3.5 times the length of ejaculatory apodeme; projections in the aedeagal complex curved and joined at apex. The subgenus Brachitrichomyia was proposed for grouping seven species from Costa Rica, Colombia, Brazil and Panama.
Species included. T. armata Barretto; T. brasiliensis, Satchell; T. inermis Barretto; T. plumata Araújo & Bravo; T. pseudodactylis, Quate; T. quatei, Bravo and T. risaraldensis Bejarano.
description: Published as part of Araújo, Maíra Xavier & Bravo, Freddy, 2016, Description of fourty four new species, taxonomic notes and identification key to Neotropical Trichomyia Haliday in Curtis (Diptera: Psychodidae, Trichomyiinae), pp. 1-76 in Zootaxa 4130 (1) on page 12, DOI: 10.11646/zootaxa.4130.1.1, http://zenodo.org/record/262717
Resistance to vesicant injury by efflux transporters
Creators: name: Udasin, Ronald G.
Publisher: name: No Publisher Supplied
Year: 2015

description: Sulfur mustard and nitrogen mustard (mechlorethamine, HN2) are potent vesicants used in chemical warfare and cancer chemotherapy that primarily target skin, eye, and lung. These electrophilic, bifunctional alkylating agents cause oxidative stress and persistent tissue damage.  Toxicity of related mustards, chlorambucil and melphalan, is limited by clearance from cells by multidrug resistance-associated protein 1 (MRP1/Mrp1), a transmembrane ATPase that stimulates efflux of glutathione-conjugated electrophiles. HN2 causes injury by covalently modifying biomolecules including glutathione. Monofunctional glutathione adducts contribute to cytotoxicity or are exported by MRP1/Mrp1. In A549 lung epithelial cells, which express MRP1 and MRP2, HN2 inhibits growth (IC5o = 0.18 µM), and inhibition of MRPs by MK-571 increases sensitivity to HN2 (IC50 = 0.045 µM).  Similar effects are seen for other bifunctional mustards chlorambucil and melphalan.  Using human embryonic kidney (HEK) 293 cells overexpressing MRP1 and MRP2, we determined that MRP1 provides resistance to HN2 while MRP2 does not protect the cells.  HN2 inhibited MRP functional activity in both A549 cells and HEK cells overexpressing MRP1, and increased sensitivity to growth inhibition induced by MRP1/Mrp1 substrates etoposide, methotrexate, and vincristine in A549 cells.  PAM212 cells and primary mouse keratinocytes express Mrp1 mRNA and protein.   Activation of the transcription factor Nrf2 by sulforaphane increased Mrp1 mRNA, protein expression and activity in PAM212 cells and protected cells against HN2-induced growth inhibition (IC50 = 1 and 13 µM without and with sulforaphane, respectively).  This protection was reversed by MK-571 (IC50 = 0.63 µM).  Sulforaphane increased Mrp1 mRNA and protein expression and activity and decreased HN2 growth inhibition in primary keratinocytes (IC50 = 1.4 and 4.8 µM without and with sulforaphane, respectively).  This attenuation was reversed by MK-571 (IC50 = 0.27 µM).  MK-571 increases HN2-induced cytotoxicity in primary mouse keratinocytes (growth inhibition IC50 = 1.4 and 0.48 µM, without and with MK-571, respectively).  Sulforaphane did not protect keratinocytes from Nrf2-/- mice (IC50 = 0.31 and 0.14 µM without and with sulforaphane, respectively).  These data show MRP1/Mrp1-mediated efflux is important for regulating HN2 injury.  Inhibiting MRP1/Mrp1 may increase mustard efficacy in cancer chemotherapy, while enhancing transport may represent a promising route to mitigate vesicant-induced cytotoxicity.
Similosodus palavanicus
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Similosodus
Similosodus palavanicus

description: 79. Similosodus palavanicus (Breuning, 1939)
Philippines: Palawan isl., Roxas, 03. 2021 (1, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 246, DOI: 10.5281/zenodo.10905476
Identification of distinct macrophage subpopulations during nitrogen mustard-induced lung injury and fibrosis
Creators: name: Venosa, Alessandro
Publisher: name: No Publisher Supplied
Year: 2015

description: Nitrogen mustard (NM) is an alkylating agent known to cause extensive pulmonary injury progressing to fibrosis. This is accompanied by a persistent infiltration of activated macrophages into the lungs which contribute to the development, progression and resolution of tissue damage. Macrophages are highly plastic cells capable of altering their activation state depending on the surrounding microenvironment. Two major phenotypically distinct subpopulations of macrophages have been identified: proinflammatory/cytotoxic M1 and antiinflammatory/wound repair M2 macrophages.  Treatment of rats with NM (0.125 mg/kg) resulted in sequential infiltration of iNOS+ and CD11b+CD43+ M1 proinflammatory/cytotoxic macrophages into the lung 1-3 d after exposure, followed by accumulation of CD68+, CD163+, CD206+, YM-1+, ARG-II+  and CD11b+CD43-  M2 macrophages, which were most notable at 28 d. This correlated with acute injury and fibrogenesis. Expression of chemokine receptors involved in recruitment of M1 and M2 bone marrow (CCR2+ and CX3CR1+, respectively) and splenic (ATR-1α+) macrophages was also upregulated. Splenectomy resulted in increased numbers of CCR2+, iNOS+ and CD11b+CD43+ proinflammatory M1 macrophages in the lung 1-7 d post exposure. Conversely CD11b+CD43- M2 antiinflammatory/wound repair macrophage accumulation and gene expression was blunted. These changes in macrophage in the lung correlated with heightened tissue injury and more rapid fibrosis. Early after NM exposure, miRNAs involved in regulating the inflammatory response (miR-125, miR-9) were upregulated in lung macrophages. With time, miRNAs involved in promoting proliferation and fibrosis (let7, miR-21, miR-29) were upregulated. Increased expression of HDAC, which regulate histone activity, as well as H3K9Ac and H3K4TM, were also upregulated early after NM exposure.   HDAC inhibition using valproic acid resulted in reduced activation of M1proinflammatory/cytotoxic macrophages and increased activation of M2 antiinflammatory/wound repair macrophages, suggesting a pathway regulating macrophage activity in the lung after NM exposure. Identification of macrophage subpopulations participating in the inflammatory response and understanding the mechanisms regulating their activation and recruitment may lead to more targeted and effective treatment against vesicant-induced pulmonary injury.
Neural behavioral outcomes of a ketogenic diet in engrailed-2 null male mice
Creators: name: Verpeut, Jessica Lynn
Publisher: name: No Publisher Supplied
Year: 2015

description: A ketogenic diet (KD), high in fat and low in carbohydrates, reduces seizure activity in pediatric epilepsy and improves autistic-related behaviors, but the neural mechanisms involved in these improvements are unknown. In the following studies Engrailed-2 (En2) knockout (KO, En2-/-) and wild-type (WT) male mice were fed either a KD or control diet (CD) from postnatal day (PND) 21 to PND 60 (childhood to young adulthood). We hypothesized that a KD fed during this critical time period would alter biogenic amine concentration, metabolism, behavioral deficits, and ultimately neural activation in En2-/- mice. Biogenic amine levels of norepinephrine (NE), dopamine (DA), and serotonin (5-HT) were reduced in forebrain regions and increased in the cerebellum of KO mice, consistent with previous findings. A KD increased hypothalamic NE in WT mice, but not in KO mice. Social behaviors, i.e. frontal contact, were increased and repetitive grooming behaviors reduced in KO-KD. Regardless of previous diet, KO mice displayed increased chow intake post-restraint stress, indicative of a coping response. A KD restored body weight in KO mice by increasing lean mass to WT-KD, but also increased fat mass. KO-KD had enhanced fat metabolism, increased blood glucose response, and reduced blood pressure. KO-KD exposed to a stranger mouse had increased c-Fos immunoreactivity in the cingulate cortex, septal region, and paraventricular nucleus of the hypothalamus (PVN). KO-CD spent more time interacting with a novel object and had increased c-Fos immunoreactivity in the bed nucleus of the stria terminalis (BNST) and PVN. The unique activation of the cingulate and septal region in KO-KD with exposure to a stranger mouse, suggests that these areas could be critical for social behaviors. This research has implications for understanding the impact of a KD on neural development and autistic-like behaviors.
Inhibition of breast cancer progression with Vitamin D compounds
Creators: name: Wahler, Joseph
Publisher: name: No Publisher Supplied
Year: 2015

description: Early epidemiological studies have shown an inverse correlation of increased vitamin D3 to breast cancer. Since this discovery, many studies have linked 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, and vitamin D analogs to decreased cell proliferation, invasion, and metastasis. The pharmacological dose of 1,25(OH)2D3 required to elicit a response can induce hypercalcemic toxicity. Therefore, non-calcemic vitamin D analogs, such as BXL0124, have been of interest in the inhibition of breast cancer.   Breast cancer is a heterogeneous disease which proceeds through a natural progression, beginning with early hyperplasia and culminating in invasive or metastatic disease. Ductal carcinoma in situ (DCIS) is a non-malignant lesion of the breast with the potential to progress to invasive ductal carcinoma (IDC). Due to the implications of breast cancer stem cells (BCSCs) in breast cancer progression, we investigated the role of vitamin D compounds on these processes.  We showed that BXL0124 inhibited the progression of DCIS to IDC in a model of breast cancer progression by maintaining critical DCIS structures through the modulation of matrix metalloproteinases transcription. In addition, BXL0124 treatment decreased cell proliferation and maintained vitamin D receptor (VDR) levels in tumors. VDR was expressed in a variety of clinical breast tumors and was lost during malignant transformation of normal mammary cells to pre-malignant histological types, suggesting vitamin D supplementation as a preventative agent due to higher VDR levels in normal breast tissue.   Vitamin D compounds (125(OH)2D3 or BXL0124) reduced the growth and self-renewal of mammospheres, an assay which enriches for BCSCs. The putative CD44+/CD24-/low BCSC population was shifted to a population expressing higher CD24 in vitro and in vivo by treatment with BXL0124. Pluripotency genes such as CD44 and OCT4 were also repressed, contributing to the reduction in cell and tumor growth.   We demonstrated the therapeutic potential of Gemini vitamin D analog BXL0124 on the inhibition of breast cancer progression and the ability of vitamin D compounds to repress the BCSC population in vitro and in vivo, potentially contributing to the effects on tumor progression.
Profile analysis and In vitro absorption study of citrus peel polymethoxyflavones
Creators: name: Wang, Ruolin
Publisher: name: No Publisher Supplied
Year: 2015

description: Polymethoxyflavones (PMFs) are a group of flavonoids found exclusively in citrus genus that have been identified with many potent biological activities, including anti-inflammation, anti-cancer, anti-atherosclerosis, and antioxidant. However, the bioavailability of PMFs is seldom studied. As far as we know, PMFs have poor aqueous solubility, and may potentially have high permeability due to their lipophilic structure.     Biological studies rely on efficient separation method to obtain pure compounds. Silica gel column chromatography was utilized in this study to separate individual PMFs from aged orange peel extracts, and the yielded products had more than 95% purity. With this established method, purified PMF derivatives from chemical modification were also obtained.     In this research, we systemically investigated permeability and solubility of totally six PMFs and their derivatives, namely, sinensetin (SIN), 5-hydroxy-sinensetin (5-OH-SIN), 5-acetyl-sinensetin (5-Ac-SIN), 3,5,6,7,8,3’,4’-Heptamethoxyflavone (HeptaMF), 5-hydroxy-3,6,7,8,3’,4’-hexamethoxyflavone (5-OH-HeptaMF), and 5-acetyl-3,6,7,8,3’,4’-hexamethoxyflavone (5-Ac-HeptaMF). Among them, 5-OH-SIN, 5-Ac-SIN, and 5-Ac-HeptaMF were prepared via chemical modification. From the octanol/water solubility test, it was found that PMFs and their derivatives had very low aqueous solubility. Permeability experiment via Caco-2 cell monolayer transport model was conducted indicating high permeability of all the tested compounds. Furthermore, PMFs had the greatest permeability, followed by 5-acetyl PMFs and 5-hydroxy PMFs. Moreover, metabolism especially deacetylation was observed during the transport of 5-acetyl PMFs. Considering permeability and solubility together, PMFs and their derivatives are expected having good absorption. This study gives indicative information on the bioavailability of PMFs and their derivatives, which provides clues on the application of PMFs in functional food or nutraceutical products.
MOESM9 of Network reconstruction and systems analysis of plant cell wall deconstruction by Neurospora crassa
Creators: name: Areejit Samal
name: Craig, James
name: Coradetti, Samuel
name: J. Benz
name: Eddy, James
name: Price, Nathan
name: N. Glass
Publisher: name: Figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 9. Functional category analysis of the 26 intersection sets among the up-regulons for seven conditions with 5 or more genes (shown in Fig. 4c). Information on the functional category of N. crassa genes was obtained from Munich Information Center for Protein Sequence (MIPS) database [73, 109]. The ‘Others’ category includes genes with functional categorization different from the 10 categories listed in the legend. The ‘Unknown function’ category includes genes with unclassified or unknown function. The relative contribution of a functional category to each set of genes is depicted with the total number of genes in each pool equal to 100%.
Impact of sand topdressing on turf quality, surface physical properties and disease severity of putting green turfs
Creators: name: Wang, Ruying
Publisher: name: No Publisher Supplied
Year: 2015

description: Topdressing sand is applied to maintain desirable surface root zone characteristics on golf course putting greens; however, coarse sand interferes with mowing and playability. Additionally, sand topdressing applied to annual bluegrass (Poa annua L. f. reptans [Hauskins] T. Koyama) turf can reduce anthracnose severity (caused by Colletotrichum cereale Manns sensu lato Crouch, Clarke, and Hillman). Three field trials were conducted from 2010 to 2013 to evaluate the effect of sand size and topdressing rate on turf performance, disease severity and surface root zone characteristics. Increasing topdressing rate was more effective at improving the quality of ‘Greenwich’ velvet bentgrass (Agrostis canina L.) turf than varying sand size; however, a substantial quantity of sand particles remained on the surface when medium-coarse sand was applied. Conversely, topdressing with medium-fine sand was readily incorporated into the turf. All topdressing treatments increased saturated hydraulic conductivity estimated from tension infiltrometer measurements. Topdressing annual bluegrass turf with medium-coarse, medium, or medium-fine sand improved turf quality and suppressed anthracnose severity compared to non-topdressed turf, and finer sands were much easier to incorporate into the turf than medium-coarse sand. Increasing topdressing rate from 0 to 1.2 and 2.4 L m-2 during the spring was more effective at improving turf quality and reducing anthracnose severity than increasing the rate of autumn topdressing. Topdressing rates (0, 0.075 or 0.15 L m-2 applied every two weeks) during the summer were too low to consistently reduce anthracnose severity and increase turf quality. Increasing spring or autumn topdressing rate reduced organic matter concentration and increased mat layer depth more than summer topdressing. Across all trials, increasing topdressing rates also reduced volumetric water content of the 0- to 3.8-mm surface root zone. Plots topdressed with greater quantities of sand often had decreased surface hardness when measured with a Clegg Impact Soil Tester; however, a depth measuring penetrometer indicated that surface strength often increased. The beneficial effects of topdressing with medium-fine sand suggest that sands finer than typically used for construction of root zones may be useful for topdressing putting green turf. Additionally, topdressing during spring is more effective than autumn for suppressing anthracnose disease.
MOESM8 of Network reconstruction and systems analysis of plant cell wall deconstruction by Neurospora crassa
Creators: name: Areejit Samal
name: Craig, James
name: Coradetti, Samuel
name: J. Benz
name: Eddy, James
name: Price, Nathan
name: N. Glass
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 8. Comparative analysis of the down-regulons for the seven conditions. Analogous to up-regulon (for brevity referred to as ‘regulon’ in main text), the down-regulon for a growth condition can be defined as genes that were downregulated and differentially expressed in comparison to both NoC and sucrose controls. a Horizontal bar plot shows the size of the down-regulons for seven conditions. The down-regulons for Avicel, xylan, XG, mannan, MLG, pectin and starch, were determined to contain 3, 45, 41, 30, 5, 35 and 236 genes, respectively (Additional file 4). Vertical bar plot shows the 11 intersection sets among the seven down-regulons with 4 or more genes and was generated using UpSetR [108]. It is seen that 220 out of 236 genes in the starch down-regulon, 26 out of 45 genes in the xylan down-regulon, 20 out of 41 genes in the XG down-regulon, 17 out of 35 genes in the pectin down-regulon, and 8 out of 30 genes in the mannan down-regulon, have no overlap with other down-regulons. It is also seen that 10 genes are common between XG and mannan down-regulons, 6 genes between xylan and starch down-regulons, 5 genes between xylan and pectin down-regulons, 4 genes between xylan and XG down-regulons, 4 genes between mannan and pectin down-regulons, and 4 genes between pectin and starch down-regulons. b Functional category analysis [73] of the 11 intersection sets among the down-regulons for seven conditions with four or more genes. Information on the functional category of N. crassa genes was obtained from Munich Information Center for Protein Sequence (MIPS) database [73, 109]. The ‘Others’ category includes genes with functional categorization different from the 10 categories listed in the legend. The ‘Unknown function’ category includes genes with unclassified or unknown function. The relative contribution of a functional category to each set of genes is depicted with the total number of genes in each pool equal to 100%.
Trichomyia nebulicola
Creators: name: Araújo, Maíra Xavier
name: Bravo, Freddy
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Trichomyia
Trichomyia nebulicola

description: nebulicola group
Species of this group have a sclerotized, bare gonostylus with pointed apex.
description: Published as part of Araújo, Maíra Xavier & Bravo, Freddy, 2016, Description of fourty four new species, taxonomic notes and identification key to Neotropical Trichomyia Haliday in Curtis (Diptera: Psychodidae, Trichomyiinae), pp. 1-76 in Zootaxa 4130 (1) on page 12, DOI: 10.11646/zootaxa.4130.1.1, http://zenodo.org/record/262717
MOESM9 of Network reconstruction and systems analysis of plant cell wall deconstruction by Neurospora crassa
Creators: name: Areejit Samal
name: Craig, James
name: Coradetti, Samuel
name: J. Benz
name: Eddy, James
name: Price, Nathan
name: N. Glass
Publisher: name: Figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 9. Functional category analysis of the 26 intersection sets among the up-regulons for seven conditions with 5 or more genes (shown in Fig. 4c). Information on the functional category of N. crassa genes was obtained from Munich Information Center for Protein Sequence (MIPS) database [73, 109]. The ‘Others’ category includes genes with functional categorization different from the 10 categories listed in the legend. The ‘Unknown function’ category includes genes with unclassified or unknown function. The relative contribution of a functional category to each set of genes is depicted with the total number of genes in each pool equal to 100%.
Acoustic manipulation of sound with soft material-based actuators
Creators: name: Wang, Yanjun
Publisher: name: No Publisher Supplied
Year: 2015

description: This thesis describes a unique parabolic acoustic manipulator with an inflatable structure, which has high gain and directivity. We created a morphable elastomeric reflecting surface with a diameter of 14 cm (6 in).  Applying vacuum deforms the device into a concave structure, which provides directional amplification of incoming acoustic waves. In addition, the author characterized the impedance of the soft material employed in the acoustic reflector, Ecoflex 00-10, in an impedance tube. Ecoflex 00-10 has a measured reflection coefficient of approximately 0.9 at frequencies ranging from 500 Hz to 5000 Hz.  This new characterization suggests this class of silicone-based elastomers is capable of advanced morphable devices to manipulate sound. Simulations also demonstrate that the soft reflecting surface is capable of transformation into a set of desired parabolic shapes between an initial planar geometry (neutral position) and a configuration with maximum curvature. With an applied vacuum, the membrane reaches its maximum deformation limited by the aluminum housing.  At this stage of actuation, experimental results show the deformed membrane has similar gain and directionality (polar response) as rigid parabolic reflectors. This type of system might find future uses for adjustable parabolic microphones and long-range communication devices.
Similosodus signatus
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Similosodus
Similosodus signatus

description: 80. Similosodus signatus (Breuning, 1939)
Philippines: Mindanao isl., Bukidnon, Mt. Kalatungan, 12.2018 (1, local collector leg.); Mindanao isl., Zamboanga del Norte, Gutallac, 12.2017 (2, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 246, DOI: 10.5281/zenodo.10905476
Development of inversion-based feedforward-feedback control techniques for advanced manufacturing
Creators: name: Wang, Zhihua
Publisher: name: No Publisher Supplied
Year: 2015

description: Advanced manufacturing aims to make high-quality products at low cost with high efficiency and highly integrated/controlled processes, thereby, promoting the process integration and providing accommodation of customized and cost-effective miniaturized products. With the increasing demands on product precision and cost efficiency in micro- and nano-scale manufacturing, the development and implementation of control technologies have become an indispensable part of advanced manufacturing. However, challenges exist in the process control of micro- and nano-scale manufacturing. The system dynamics, in general, is complicated and can be excited when the micro- and nano- manufacturing are conducted at high speeds, and other adverse effects including the hysteresis and creep effects of the actuators further complicates the precision control of the manufacturing system. Additional challenges also arise from the variation/uncertainty and environmental disturbances. It has been demonstrated that micromanufacturing could benefit from the augment of ultrasonic vibration in achieving lower power consumptions and elongated tool life. However, the fundamental mechanism of ultrasonic vibration effect on micromanufacturing has not yet been understood. Similar challenges also exist in probe-based nanomanufacturing as the patterning throughput is ultimately limited by the patterning speed, which, in turn, is limited by the vibrational dynamics and hysteresis effect, as well as the cross-axis dynamics coupling effect of the actuation system. Further challenge arises when patterning directly on hard materials using probe-based approach --- even with stiff probe of hardest material, the pattern obtained on hard sample such as tungsten is hardly of any practical usage (feature depth $
Additional file 1: Table S1. of Metabolic status of CSF distinguishes rats with tauopathy from controls
Creators: name: Karlíková, Radana
name: Kateřina Mičová
name: Lukáš Najdekr
name: Alžběta Gardlo
name: Tomáš Adam
name: Majerová, Petra
name: Friedecký, David
name: Kováč, Andrej
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Abbreviations of metabolites used in targeted metabolomic analysis. Tables S2, S3. Results of analysis of CSF from confirmatory study: targeted analysis (Table S2) and untargeted (Table S3). Table S4. Twenty most discriminating features from untargeted analysis of brain tissue samples. Figure S1. Expression levels of insoluble tau proteins in brainstem of transgenic animals used for study. Figures S2, S3, S4, S5, S6, S7. OPLS-DA score scatterplots and S-plots built for targeted and untargeted metabolomics: CSF targeted (Fig. S2) and untargeted (Fig. S5) metabolomics, plasma targeted (Fig. S3) and untargeted (Fig. S6) metabolomics, brain tissue targeted (Fig. S4) and untargeted (Fig. S7) metabolomics. Figures S8, S9. OPLS-DA score scatterplots and S-plots built for targeted and untargeted metabolomics of CSF in confirmation study: targeted (Fig. S8) and untargeted (Fig. S9) metabolomics. Figure S10. Box plots of most discriminating features of brain tissue samples in untargeted metabolomic analysis. (DOCX 4660 kb)
Hirtaeschopalaea albolineata Pic 1925
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Hirtaeschopalaea
Hirtaeschopalaea albolineata

description: 81. Hirtaeschopalaea albolineata Pic, 1925
Malaysia: Borneo isl., Sabah, Trus Madi Mt., Tumbunan Distr., 1000 m, 24.- 27.04.2010 (1, ex coll. V.Kalinin).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 246, DOI: 10.5281/zenodo.10905476
Assessing life history tradeoffs in host range mutants of RNA bacteriophage phi6
Creators: name: Watson, Aubrey Miles
Publisher: name: No Publisher Supplied
Year: 2015

description: Studies on host range mutation and its effects on phage fitness are common for bacteriophage phi6. Expanding to a novel host can occur through a large number of mutations which provide a new resource for use typically at a decreased level of reproduction. Secondary mutations developed during evolution on the novel host can raise phage fitness but may also lead to specialization on that host. Again, the mutations that are beneficial on the novel host are usually detrimental on the initial host. Studying phage life history traits such as fecundity (reproduction rate and size) as well as competitive ability on the hosts may help determine where fitness is lost. Here I used host range mutants of phi6 that were previously evolved on P. pseudoalcaligenes East River Isolate A (ERA). I performed paired growth assays on original host P. syringae pathovar phaseolicola (PP) and burst assays on both PP and ERA to determine the effects of these mutations on the phage’s reproductive ability. My selection of phages includes a specialist on PP, a specialist on ERA, and generalists capable of infecting more than one host. Paired growth assays showed that two of the five mutants suffer a fitness cost relative to the wild type ancestor on PP. However, burst assays showed no significant difference between the wild type and evolved mutants on PP. Burst assays on ERA showed that several mutants improved their burst time and all mutants improved their burst sizes compared to their ancestor on that host. The evolved mutants were not able to separate themselves from one another. Mutants separated by one mutation showed significant effects from these differences. My results suggest that burst and fitness assays can be a component for assessing differences in phage life history but need to be supplemented with further experimentation.
Human Responses to RF Exposure in Mosque Settings: A Study on Focus and EMF Shielding Efficacy
Creators: name: Maskeen, Mann
Publisher: name: Zenodo
Year: 2025

description: This study explores the impact of RF exposure on focus and well-being in mosque environments, where modern technologies like mobile phones, LED lighting, Wi-Fi, and solar panels contribute to rising electromagnetic fields. Involving 20–30 participants, the research uses tools such as a Trifield meter, EEG, and HRV monitors to assess cognitive and physiological responses during worship. It also evaluates the effectiveness of Shieldex P130+B garments in reducing RF exposure and enhancing mindfulness (khushu'). By addressing the potential distractions and health effects of RF radiation, the study aims to provide practical strategies for improving focus and well-being in sacred spaces.