cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lyman-alpha Forest Tomography from Background Galaxies: The First Megaparsec-Resolution Large-Scale Structure Map at z>2
Creators: name: Lee, Khee-Gan
name: Hennawi, Joseph F.
name: Stark, Casey
name: Prochaska, J. Xavier
name: White, Martin
name: Schlegel, David J.
name: Eilers, Anna-Christina
name: Arinyo-i-Prats, Andreu
name: Suzuki, Nao
name: Croft, Rupert A. C.
name: Caputi, Karina I.
name: Cassata, Paolo
name: Ilbert, Olivier
name: Garilli, Bianca
name: Koekemoer, Anton M.
name: Brun, Vincent Le
name: Fèvre, Olivier Le
name: Maccagni, Dario
name: Nugent, Peter
name: Taniguchi, Yoshiaki
name: Tasca, Lidia A. M.
name: Tresse, Laurence
name: Zamorani, Gianni
name: Zucca, Elena
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first observations of foreground Lyman-$α$ forest absorption from high-redshift galaxies, targeting 24 star-forming galaxies (SFGs) with $z\sim 2.3-2.8$ within a $5' \times 15'$ region of the COSMOS field. The transverse sightline separation is $\sim 2\,h^{-1}\mathrm{Mpc}$ comoving, allowing us to create a tomographic reconstruction of the 3D Ly$α$ forest absorption field over the redshift range $2.20\leq z\leq 2.45$. The resulting map covers $6\,h^{-1}\mathrm{Mpc} \times 14\,h^{-1}\mathrm{Mpc}$ in the transverse plane and $230\,h^{-1}\mathrm{Mpc}$ along the line-of-sight with a spatial resolution of $\approx 3.5\,h^{-1}\mathrm{Mpc}$, and is the first high-fidelity map of large-scale structure on $\sim\mathrm{Mpc}$ scales at $z>2$. Our map reveals significant structures with $\gtrsim 10\,h^{-1}\mathrm{Mpc}$ extent, including several spanning the entire transverse breadth, providing qualitative evidence for the filamentary structures predicted to exist in the high-redshift cosmic web. Simulated reconstructions with the same sightline sampling, spectral resolution, and signal-to-noise ratio recover the salient structures present in the underlying 3D absorption fields. Using data from other surveys, we identified 18 galaxies with known redshifts coeval with our map volume enabling a direct comparison to our tomographic map. This shows that galaxies preferentially occupy high-density regions, in qualitative agreement with the same comparison applied to simulations. Our results establishes the feasibility of the CLAMATO survey, which aims to obtain Ly$α$ forest spectra for $\sim 1000$ SFGs over $\sim 1 \,\mathrm{deg}^2$ of the COSMOS field, in order to map out IGM large-scale structure at $\langle z \rangle \sim 2.3$ over a large volume $(100\,h^{-1}\mathrm{Mpc})^3$.
description: Accepted for publication in Astrophysical Journal Letters; 8 pages and 5 figures
Transient Demyelination Increases the Efficiency of Retrograde AAV Transduction
Creators: name: Gray, Steven J
name: Jamshidi, Pouya
name: Lorenzana, Ariana O
name: Samulski, Richard J
name: Lee, Jae K
name: Zheng, Binhai
name: Hollis, Edmund R
name: Tuszynski, Mark H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Adeno-associated virus (AAV) is capable of mediating retrograde viral transduction of central and peripheral neurons. This occurs at a relatively low efficiency, which we previously found to be dependent upon capsid serotype. We sought to augment retrograde transduction by providing increased axonal access to peripherally delivered AAV. Others have described utilizing full transection of peripheral nerves to mediate retrograde viral transduction of motor neurons. Here, we examined the ability of a transient demyelinating event to modulate levels of retrograde AAV transduction. Transient demyelination does not cause lasting functional deficits. Ethidium bromide (EtBr)–induced transient demyelination of the sciatic nerve resulted in significant elevation of retrograde transduction of both motor and sensory neurons. Retrograde transduction levels of motor neurons and heavily myelinated, large-diameter sensory neurons increased at least sixfold following peripheral delivery of self-complementary AAV serotype 1 (scAAV1) and serotype 2 (scAAV2), when preceded by demyelination. These findings identify a means of significantly enhancing retrograde vector transport for use in experimental paradigms requiring either retrograde neuronal identification and gene expression, or translational treatment paradigms.
Additional file 1 of Implementation strategies for decentralized management of multidrug-resistant tuberculosis: insights from community health systems in Zambia
Creators: name: Zulu, Joseph Mumba
name: Maritim, Patricia
name: Halwiindi, Hikabasa
name: Chavula, Malizgani Paul
name: Munakampe, Margarate
name: Matenga, Tulani Francis L.
name: Mweemba, Chris
name: Sinyangwe, Ntazana N.
name: Habib, Batuli
name: Musukuma, Mwiche
name: Silumbwe, Adam
name: Wang, Bo
name: Kaonga, Patrick
name: Chewe, Mwimba
name: Fisa, Ronald
name: Banda, Jeremiah
name: Mubanga, Angel
name: Phiri, Henry
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Exciting spiral arms in protoplanetary discs from flybys
Creators: name: Smallwood, Jeremy L.
name: Yang, Chao-Chin
name: Zhu, Zhaohuan
name: Martin, Rebecca G.
name: Dong, Ruobing
name: Cuello, Nicolás
name: Isella, Andrea
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Spiral arms are observed in numerous protoplanetary discs. These spiral arms can be excited by companions, either on bound or unbound orbits. We simulate a scenario where an unbound perturber, i.e. a flyby, excites spiral arms during a periastron passage. We run three-dimensional hydrodynamical simulations of a parabolic flyby encountering a gaseous protoplanetary disc. The perturber mass ranges from $10\, \rm M_J$ to $1\, \rm M_{\odot}$. The perturber excites a two-armed spiral structure, with a more prominent spiral feature for higher mass perturbers. The two arms evolve over time, eventually winding up, consistent with previous works. We focus on analysing the pattern speed and pitch angle of these spirals during the whole process. The initial pattern speed of the two arms are close to the angular velocity of the perturber at periastron, and then it decreases over time. The pitch angle also decreases over time as the spiral winds up. The spirals disappear after several local orbital times. An inclined prograde orbit flyby induces similar disc substructures as a coplanar flyby. A solar-mass flyby event causes increased eccentricity growth in the protoplanetary disc, leading to an eccentric disc structure which dampens over time. The spirals' morphology and the disc eccentricity can be used to search for potential unbound stars or planets around discs where a flyby is suspected. Future disc observations at high resolution and dedicated surveys will help to constrain the frequency of such stellar encounters in nearby star-forming regions.
description: 17 pages, 18 figures, accepted to MNRAS
PERFORMABILITY ANALYSIS OF MULTISTATE ASH HANDLING SYSTEM OF THERMAL POWER PLANT WITH HOT REDUNDANCY USING STOCHASTIC PETRINETS
Creators: name: Er. Sudhir Kumar
name: Dr. P.C. Tewari
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Availability
Performability
Petri Nets
Ash Handling System

description: This work seeks to propose a Petri nets-based technique for evaluating the performability features of ash handling system of a coal-based thermal power plant. The impact of failure and repair parameters on system performance has been determined. For the modelling of the system Stochastic Petri Nets (SPN) an extended version of Petri nets is applied. The recommended methodology used in this study allows for a better understanding of the system's performance behavior under various operating situations. The study provides Decision Support System which will assist managers in making informed decisions about inventory and spare parts for plant operations.
Predictive Convolutional Long Short-Term Memory Network for Detecting Anomalies in Smart Surveillance
Creators: name: Patel, Priyanka
name: Dr. Amit Nayak
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Predictive ConvolutionLSTM
Distributed convolutional neural network
long short-term memory
Spatiotemporal Autoencoder
TDSTConvLSTM
Video Surveillance
Anomaly detection
Machine Learning
Deep Learning
Smart Video Monitoring

description: Surveillance is the monitoring of behavior, actions, or information, with the purpose of collecting, influencing, controlling, or guiding evidence. Despite the technical traits of cutting-edge science, it is difficult to detect abnormal events in the surveillance video and requires exhaustive human efforts. Anomalous events in the video remain a challenge due to the occlusions of objects, different densities of the crowd, cluttered backgrounds & objects, and movements in complex scenes and situations. In this paper, we propose a new model called time distributed convolutional neural network long short-term memory Spatiotemporal Autoencoder (TDSTConvLSTM), which uses a deep neural network to automatically learn video interpretation. Convolution neural network is used to extract visual features from spatial and time distributed LSTM use for sequence learning in temporal dimensions. Since most anomaly detection data sets are restricted to appearance anomalies or unusual motion. There are some anomaly detection data-sets available such as the UCSD Pedestrian dataset, CUHK Avenue, Subway entry-exit, ShanghaiTech, street scene, UCF-crime, etc. with varieties of anomaly classes. To narrow down the variations, this system can detect cyclists, bikers, skaters, cars, trucks, tempo, tractors, wheelchairs, and walkers who are walking on loan (off the road) which are visible under normal conditions and have a great impact on the safety of pedestrians. The Time distributed ConvLSTM has been trained with a normal video frame sequence belonging to these mentioned classes. The experiments are performed on the mentioned architecture and with benchmark data sets UCSD PED1, UCSD PED2, CUHK Avenue, and ShanghaiTech. The Pattern to catch anomalies from video involves the extraction of both spatial and temporal features. The growing interest in deep learning approaches to video surveillance raises concerns about the accuracy and efficiency of neural networks. The time distributed ConvLSTM model is good compared to benchmark models.
Evidence for biotic control of Australian reservoir phytoplankton communities and the potential for applied biomanipulation
Creators: name: Matveev, Vladimir
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Although some concerns have been expressed with respect to the applicability of biomanipulation to Australian reservoirsand other inland waters, no major obstacles were found in this review. The previous doubts stimulated research, which hasprovided evidence for unexpected mechanisms of food web interactions, such as positive effects of small copepods onplanktonic algae, higher than usual grazing potential of cladoceran communities, and direct positive effects of planktivoreson phytoplankton. Further research into zooplankton-cyanobacteria interactions should indicate how widespread is thepreviously reported ability of some southern hemisphere crustaceans to benefit at a population level from feeding on cyanobacteria.Quantitative fisheries acoustics, which has not been widely used in biomanipulation trials before, is a promising newtool in the assessment of the biomass of planktivorous fish in the pelagic zone of reservoirs.
Monitoraggio e conservazione dei beni culturali Lapidei:indagini diagnostiche mediante tecniche Di superficie e metodologie innovative per Interventi di manutenzione sostenibile
Creators: name: Cardellicchio, Francesco
Publisher: name: Universita degli studi di Salerno
Year: 2022
Subjects: subject: CHIM/01 CHIMICA ANALITICA

description: 2020 - 2021
description: In recent decades, the historical and artistic heritage has undergone a greater degradation than in the past, in relation to the synergic action of atmospheric pollution, climate changes, and biological contamination. The conservation of cultural heritage, therefore, requires, in addition to the reduction of environmental pollution levels, also the development of increasingly innovative, effective, long-lasting, and inexpensive protection strategies. With these premises, this Ph.D. thesis was aimed at contributing to the research activities of the MIUR Project "Smart Cities, n. SCN_00520 entitled: “Product and process innovation for sustainable and planned maintenance, conservation, and restoration of cultural heritage” whose main objectives concerned:  The characterization of the various forms of degradation of stone materials, using advanced analytical techniques.  The research and development of new types of products that are not harmful to human health, with low environmental impact, highly selective, and at low cost for the restoration of degraded stone materials of cultural heritage.  The implementation of actions for the sustainable management of cultural heritage, also through the development of a technological platform for preventive interventions and scheduled maintenance. The doctorate was hosted by the Science Department of the University of Basilicata and the project was developed in collaboration with the industrial partner "Tab Consulting S.r.l." of Potenza, where an initial internship period of 6 months was carried out. In general, the main objective was to create a fruitful collaboration with other research units, using XPS (X-ray Photoelectron Spectroscopy) as the main surface analysis technique, in combination with other analytical techniques for comparative diagnosis. of stone materials, before and after the innovative treatments developed in accordance with the objectives of the “Smart Cities” project. .. [edited by Author]
Additional file 2 of Monitoring corn stover processing by the fungus Ustilago maydis
Creators: name: Robertz, Stefan
name: Philipp, Magnus
name: Schipper, Kerstin
name: Richter, Paul
name: Miebach, Katharina
name: Magnus, Jorgen
name: Pauly, Markus
name: Ramírez, Vicente
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 2
Coronary wave intensity and aortic root hemodynamics in hypertrophic obstructive cardiomyopathy
Creators: name: Francis, Nadine
Publisher: name: Imperial College London
Year: 2021

description: Introduction: Hypertrophic Obstructive Cardiomyopathy (HOCM) is a genetic cardiomyopa- thy that causes heart failure and sudden death. One of its common features is the perturbed hemodynamics of the Aortic Root (AR) and the coronary arteries originating from the AR. In this study, we investigate coronary and AR hemodynamics, as well as their interaction in HOCM patients. For Coronary Hemodynamics: We developed a Wave Intensity Analysis Matlab program to investigate the hemodynamics of the Left Anterior Descending artery (LAD), originating from the Left Coronary Sinus (LCS). We then applied the Maximum Entropy Method to identify significant peaks in 10 HOCM patients and 11 Controls. Our results show that HOCM patients have perturbed dominant and secondary waves, which could act as supplementary predictor markers of the disease due to their absence in Controls. For AR Hemodynamics: We developed a Matlab program to study the hemodynamics of the AR and its 3 sinuses of Valsalva, using Cardiac Magnetic Resonance imaging in 10 HOCM patients and 13 Controls. Our results show that the AR jet in HOCM patients is asymmetric and skewed away from the LCS, with increased fractional area of backward flow in the LCS. For Coronary and AR Interaction: We investigate possible interactions between waves in the LAD and the perturbed hemodynamics of the AR, by studying various linear correlation tests within 10 HOCM patients. Our results show that the increased fractional area of backward flow in the LCS is the most significant variable that is linearly correlated with the appearance of waves only found in HOCM. Conclusion: Our results suggest the presence of an interaction between the LAD and LCS, which was not clearly demonstrated before. Such results do not demonstrate physical causes but suggest further investigations to elucidate the mechanisms involved in such complex interaction and pathobiology of HOCM
Cовместное превращение метана и н-пентана в неокислительных условиях в присутствии алюмоплатиновых катализаторов с различной кислотностью
Creators: name: Н. В. Виниченко
name: Д. В. Голинский
name: Е. В. Затолокина
name: Е. А. Паукштис
name: И. Е. Удрас
name: А. С. Белый
Publisher: name: НефтеГазоХимия
Year: 2017
Subjects: метан
н-пентан
кислотные центры Льюиса
хемосорбция
фтор
ароматические углеводороды

description: В работе изучено влияние модифицирования -Al2O3 фтором на состояние платины на поверхности оксида алюминия и кислотные свойства носителя. Рассмотрены активация метана и состав образующихся углеводородных фрагментов в присутствии алюмоплатиновых катализаторов с различным содержанием F – (0,5–2% масс.). Установлен наиболее активный образец в реакции сопряженной конверсии метана с н-пентаном в неокислительных условиях.
Widespread Muscle Expression of an AAV9 Human Mini-dystrophin Vector After Intravenous Injection in Neonatal Dystrophin-deficient Dogs
Creators: name: Xiao, Xiao
name: Zheng, Hui
name: Kornegay, Joe N
name: Chen, Chunlian
name: Li, Juan
name: Qiao, Chunping
name: Bogan, Daniel J
name: Howard, James F
name: Wang, Bing
name: Bogan, Janet R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Duchenne (DMD) and golden retriever (GRMD) muscular dystrophy are caused by genetic mutations in the dystrophin gene and afflict striated muscles. We investigated systemic gene delivery in 4-day-old GRMD dogs given a single intravenous injection of an AAV9 vector (1.5 × 1014 vector genomes/kg) carrying a human codon-optimized human mini-dystrophin gene under control of the cytomegalovirus (CMV) promoter. One of the three treated dogs was euthanized 9 days later due to pre-existing conditions. Scattered mini-dystrophin-positive myofibers were seen by immunofluorescent (IF) staining in numerous muscles. At the end of the 16-week study, the other two dogs showed generalized muscle expression of mini-dystrophin in ~15% to nearly 100% of myofibers. Western blot and vector DNA quantitative PCR results agreed with the IF data. Delayed growth and pelvic limb muscle atrophy and contractures were seen several weeks after vector delivery. T-2 weighted magnetic resonance imaging (MRI) at 8 weeks showed increased signal intensity compatible with inflammation in several pelvic limb muscles. This marked early inflammatory response raised concerns regarding methodology. Use of the ubiquitous CMV promoter, extra-high vector dose, and marked expression of a human protein in canine muscles may have contributed to the pathologic changes seen in the pelvic limbs.
Interaction effects in non-equilibrium transport properties of a four-terminal topological corner junction
Creators: name: Romeo, F.
name: Citro, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the transport properties of a four-terminal corner junction made by etching a two- dimensional topological insulator to form a quantum point contact (QPC). The QPC geometry enables inter-boundary tunneling processes allowing for the coupling among states with different helicity, while the tight confinement in the QPC region activates charging effects leading to the Coulomb blockade physics. Peculiar signatures of these effects are theoretically investigated using a scattering field theory modified to take into account the electron-electron interaction within a self- consistent mean-field approach. The current-voltage characteristics and the current fluctuations (noise) are derived beyond the linear response regime. Universal aspects of the thermal noise of the corner junction made of helical matter are also discussed.
description: 13 pages, 8 figures
Current Status of Pharmaceutical and Genetic Therapeutic Approaches to Treat DMD
Creators: name: Clemens, Paula R
name: Dickson, George
name: Takeda, Shin'ichi
name: Xiao, Xiao
name: Pichavant, Christophe
name: Wolff, Jon A
name: Wooddell, Christine I
name: Tremblay, Jacques P
name: Aartsma-Rus, Annemieke
name: Wilton, Steve D
name: Davies, Kay E
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Duchenne muscular dystrophy (DMD) is a genetic disease affecting about one in every 3,500 boys. This X-linked pathology is due to the absence of dystrophin in muscle fibers. This lack of dystrophin leads to the progressive muscle degeneration that is often responsible for the death of the DMD patients during the third decade of their life. There are currently no curative treatments for this disease but different therapeutic approaches are being studied. Gene therapy consists of introducing a transgene coding for full-length or a truncated version of dystrophin complementary DNA (cDNA) in muscles, whereas pharmaceutical therapy includes the use of chemical/biochemical substances to restore dystrophin expression or alleviate the DMD phenotype. Over the past years, many potential drugs were explored. This led to several clinical trials for gentamicin and ataluren (PTC124) allowing stop codon read-through. An alternative approach is to induce the expression of an internally deleted, partially functional dystrophin protein through exon skipping. The vectors and the methods used in gene therapy have been continually improving in order to obtain greater encapsidation capacity and better transduction efficiency. The most promising experimental approaches using pharmaceutical and gene therapies are reviewed in this article.
Monmouth University Poll: July 2015 Iowa Republican Presidential Caucus
Creators: name: Monmouth University Polling Institute
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Registered to vote (1); voter likelihood (1); Republican/Democratic presidential caucus (1); Republican presidential caucus (3); favorability of Republican presidential candidates (17); opinion on number of candidates running for Republican presidential nomination (1); important issues in support for Republican presidential nomination (2); willingness to support candidate who you don't fully agree with in order to win presidency (1); Tea Party.
Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene Transfer
Creators: name: Pulicherla, Nagesh
name: Agbandje-McKenna, Mavis
name: Debbink, Kari
name: Govindasamy, Lakshmanan
name: Yadav, Swati
name: Shen, Shen
name: Asokan, Aravind
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We report the generation of a new class of adeno-associated virus serotype 9 (AAV9)-derived vectors displaying selective loss of liver tropism and demonstrating potential for cardiac and musculoskeletal gene transfer applications. Random mutagenesis of residues within a surface-exposed region of the major AAV9 capsid protein yielded a capsid library with mutations clustered at the icosahedral threefold symmetry axis. Using a combination of sequence analysis, structural models, and in vivo screening, we identified several functionally diverse AAV9 variants. The latter were classified into three functional subgroups, with respect to parental AAV9 displaying: (i) decreased transduction efficiency across multiple tissues; (ii) a selective decrease in liver transduction, or (iii) a similar transduction profile. Notably, variants 9.45 and 9.61 (subgroup II) displayed 10- to 25-fold lower gene transfer efficiency in liver, while transducing cardiac and skeletal muscle as efficiently as AAV9. These results were further corroborated by quantitation of vector genome copies and histological analysis of reporter (tdTomato) gene expression. The study highlights the feasibility of generating AAV vectors with selectively ablated tissue tropism, which when combined with other targeting strategies could allow sharply segregated gene expression. Liver-detargeted AAV9 variants described herein are excellent candidates for preclinical evaluation in animal models of cardiac and musculoskeletal disease.
Additional file 2 of Implementation strategies for decentralized management of multidrug-resistant tuberculosis: insights from community health systems in Zambia
Creators: name: Zulu, Joseph Mumba
name: Maritim, Patricia
name: Halwiindi, Hikabasa
name: Chavula, Malizgani Paul
name: Munakampe, Margarate
name: Matenga, Tulani Francis L.
name: Mweemba, Chris
name: Sinyangwe, Ntazana N.
name: Habib, Batuli
name: Musukuma, Mwiche
name: Silumbwe, Adam
name: Wang, Bo
name: Kaonga, Patrick
name: Chewe, Mwimba
name: Fisa, Ronald
name: Banda, Jeremiah
name: Mubanga, Angel
name: Phiri, Henry
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2
QUEUING SYSTEM WITHOUT QUEUE AND DETERMINISTIC SERVICE TIME
Creators: name: Gurami Tsitsiashvili
name: Radchenkova, Tatiana
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Poisson flow
deter ministic service time
queuing system with infinite servers

description: There is a model of fault-counting data collected in the testing process of software development. In this model it is performed simulation based on the infinite server queueing model using the generated sample data of the fault detection time to visualize the efficiency of fault correction activities. In this model the thinning method using intensity functions of the delayed S-shaped and inflection S-shaped software reliability growth models [2], [3] to generate sample data of the fault detection time from the fault-counting data. But this model does not allow to analyse such systems without dependence of input and service intensities. In this paper, we consider a queuing system model with an infinite number of servers and a deterministic service time. The input flow to the system is non-stationary Poisson. It is investigated analytically how the parameter of the Poisson distribution characterizing the number of customers in the system depends on the service time in the presence of a peak load determined by the variable intensity of the input flow. In numerical simulations it is shown how graphs of the Poisson distribution parameter depends on deterministic service time.
Efficient quantum key distribution scheme with pre-announcing the basis
Creators: name: Gao, Jingliang
name: Zhu, Changhua
name: Xiao, Heling
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We devise a new quantum key distribution scheme that is more efficient than the BB84 protocol. By pre-announcing basis, Alice and Bob are more likely to use the same basis to prepare and measure the qubits, thus achieves a higher efficiency. The error analysis is revised and its security against any eavesdropping is proven briefly. Furthermore we show that, compared with the LCA scheme, our modification can be applied in more quantum channels.
The Mass Distribution of Quasars in Optical Time-domain Surveys
Creators: name: Sun, Mouyuan
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The determination of supermassive black hole (SMBH) masses is the key to understanding the host galaxy build-up and the SMBH mass assembly histories. The SMBH masses of non-local quasars are frequently estimated via the single-epoch virial black-hole mass estimators, which may suffer from significant biases. Here we demonstrate a new approach to infer the mass distribution of SMBHs in quasars by modelling quasar UV/optical variability. Our inferred black hole masses are systematically smaller than the virial ones by $0.3\sim 0.6$ dex; the $\sim 0.3$ dex offsets are roughly consistent with the expected biases of the virial black-hole mass estimators. In the upcoming time-domain astronomy era, our methodology can be used to constrain the cosmic evolution of quasar mass distributions.
description: 9 pages, 8 figures, accepted to MNRAS
Notable Reduction in Illegitimate Integration Mediated by a PPT-deleted, Nonintegrating Lentiviral Vector
Creators: name: Li, Chengwen
name: Ma, Hong
name: Kantor, Boris
name: Samulski, Jude
name: Bayer, Matthew
name: McCown, Thomas
name: Kafri, Tal
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Nonintegrating lentiviral vectors present a means of reducing the risk of insertional mutagenesis in nondividing cells and enabling short-term expression of potentially hazardous gene products. However, residual, integrase-independent integration raises a concern that may limit the usefulness of this system. Here we present a novel 3′ polypurine tract (PPT)-deleted lentiviral vector that demonstrates impaired integration efficiency and, when packaged into integrase-deficient particles, significantly reduced illegitimate integration. Cells transduced with PPT-deleted vectors exhibited predominantly 1–long terminal repeat (LTR) circles and a low level of linear genomes after reverse transcription (RT). Importantly, the PPT-deleted vector exhibited titers and in vitro and in vivo expression levels matching those of conventional nonintegrating lentiviral vectors. This safer nonintegrating lentiviral vector system will support emerging technologies, such as those based on transient expression of zinc–finger nucleases (ZFNs) for gene editing, as well as reprogramming factors for inducing pluripotency.
Information Path to a Vote
Creators: name: Blassnig, Sina
name: Pfiffner, Nico
name: Reiss, Michael
name: Mitova, Eliza
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Communication
subject: Social and Behavioral Sciences
subject: data donation
subject: Google
subject: information behavior
subject: political communication
subject: voting campaigns
subject: YouTube

description: The aim of this study is to investigate how citizens inform themselves about upcoming votes, and whether digital information or searching behavior differs between supporters and opponents of specific political issues, but also between voters and non-voters. Additionally, we aim to investigate the relationship between the search behavior and socio-/psycho-graphic variables as well as media coverage of the vote. Methodologically, the study combines a cross-sectional survey with a data donation of participants’ Google search and YouTube histories.
One-year Treatment of Morpholino Antisense Oligomer Improves Skeletal and Cardiac Muscle Functions in Dystrophic mdx Mice
Creators: name: Lu, Qi Long
name: Nagaraju, Kanneboyina
name: Xiao, Bin
name: Xiao, Xiao
name: Wu, Bo
name: Shaban, Mona
name: Li, Juan
name: Sali, Arpana
name: Lu, Peijuan
name: Cloer, Caryn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Antisense therapy has been successful to skip targeted dystrophin exon with correction of frameshift and nonsense mutations of Duchenne muscular dystrophy (DMD). Systemic production of truncated but functional dystrophin proteins has been achieved in animal models. Furthermore, phase I/II clinical trials in United Kingdom and the Netherlands have demonstrated dystrophin induction by local and systemic administrations of antisense oligomers. However, long-term efficacy and potential toxicity remain to be determined. The present study examined 1-year systemic effect of phosphorodiamidate morpholino oligomers (PMO) treatment targeting mutated dystrophin exon 23 in mdx mice. PMO induced dystrophin expression dose-dependently and significantly improved skeletal muscle pathology and function with reduced creatine kinase (CK) levels by a regimen of 60 mg/kg biweekly administration. This regimen induced <2% dystrophin expression in the heart, but improved cardiac functions demonstrated by hemodynamics analysis. The results suggest that low levels of dystrophin induction may be able to provide detectable benefit to cardiac muscle with limited myopathy. Body weight, serum enzyme tests, and histology analysis showed no sign of toxicity in the mice treated with up to 1.5 g/kg PMO for 6 months. These results indicate that PMO could be used safely as effective drugs for long-term systemic treatment of DMD.
Expanded description of Leberis aenigmatosa Smirnov (Anomopoda:Chydoridae): a further indication of the biological isolation between western and eastern Australia
Creators: name: Frey, David G
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Leberis aenigmatosa Smirnov, which belongs to a monotypic genus endemic to Australia, is fully redescribed frommaterial collected from granite rock-pools in Western Australia. All three male instars are described for the firsttime. The redescription includes an extensive series of line drawings. Leberis shows some affinity with the genusCelsinotum Frey of eastern Australia. There is strong evidence for isolation and radiation of eastern and western chydorid populations.
Reliability Estimation of a Serial System Subject to General and Gumbel-Hougaard Family Copula Repair Policies
Creators: name: Yusuf, Ibrahim
name: Nafisatu Muhammad Usman
name: Abdulkareem Lado Ismail
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Reliability
estimation
availability
MTTF
Series system
GumbelHougaard family copula

description: The dependability analysis of a hybrid series-parallel system with five subsystems A, B, C, D, and E is the subject of this research. Subsystem A has two active parallel units, whereas subsystem B has two out of four active units. Both units have a failure and repair time that is exponential. There are two states in the system under consideration: partial failure and complete failure. To assess the system's dependability, the system's first-order partial differential equations are constructed from the system transition diagram, resolved using the supplementary variables technique, and the reliability models are Laplace transformed. Failure times are assumed to follow an exponential distribution, whereas repair times are expected to follow a general distribution and a Gumbel-Hougaard family copula distribution. Reliability measurements of testing system effectiveness are derived and investigated, including reliability, availability, MTTF, sensitivity MTTF, and cost function. Tables and graphs show some of the most relevant findings.
Proceedings Fifth International Symposium on Games, Automata, Logics and Formal Verification
Creators: name: Peron, Adriano
name: Piazza, Carla
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: Formal Languages and Automata Theory (cs.FL)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: F.4.1; F.4.3; F.1.1; D.2.4

description: This volume contains the proceedings of the Fifth International Symposium on Games, Automata, Logic and Formal Verification (GandALF 2014). The symposium took place in Verona, Italy, from 10th to 12th of September 2014. The proceedings of the symposium contain the abstracts of three invited talks and 19 papers that were accepted after a careful evaluation for presentation at the conference. The topics of the accepted papers range over a wide spectrum, including algorithmic and behavioral game theory, game semantics, formal languages and automata theory, modal and temporal logics, software verification, hybrid systems.
Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates
Creators: name: Yadav, Swati
name: Samulski, R Jude
name: Ojeda, Sergio R
name: Bachaboina, Lavanya
name: Matagne, Valerie
name: Gray, Steven J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Other labs have previously reported the ability of adeno-associated virus serotype 9 (AAV9) to cross the blood-brain barrier (BBB). In this report, we carefully characterized variables that might affect AAV9's efficiency for central nervous system (CNS) transduction in adult mice, including dose, vehicle composition, mannitol coadministration, and use of single-stranded versus self-complementary AAV. We report that AAV9 is able to transduce approximately twice as many neurons as astrocytes across the entire extent of the adult rodent CNS at doses of 1.25 × 1012, 1 × 1013, and 8 × 1013 vg/kg. Vehicle composition or mannitol coadministration had only modest effects on CNS transduction, suggesting AAV9 crosses the BBB by an active transport mechanism. Self-complementary vectors were greater than tenfold more efficient than single-stranded vectors. When this approach was applied to juvenile nonhuman primates (NHPs) at the middle dose (9–9.5 × 1012 vg/kg) tested in mice, a reduction in peripheral organ and brain transduction was observed compared to mice, along with a clear shift toward mostly glial transduction. Moreover, the presence of low levels of pre-existing neutralizing antibodies (NAbs) mostly occluded CNS and peripheral transduction using this delivery approach. Our results indicate that high peripheral tropism, limited neuronal transduction in NHPs, and pre-existing NAbs represent significant barriers to human translation of intravascular AAV9 delivery.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Nel presente articolo si descrivono le modalità di esecuzione del cursus dantesco, obbedienti sempre a schemi di una rigida simmetria. Tali lineamenti, assolutamente peculiari di Dante, si possono riscontrare anche nella cosiddetta Epistola XIV, tradizionalmente attribuita a Cangrande della Scala. Ciò induce senz’altro a cambiare la paternità dell’epistola, che andrà ascritta al corpus epistolare dantesco.
First Observation of Chromospheric Waves in a Sunspot by DKIST/ViSP: The Anatomy of an Umbral Flash
Creators: name: French, Ryan J.
name: Bogdan, Thomas J.
name: Casini, Roberto
name: de Wijn, Alfred G.
name: Judge, Philip G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: The Visible Spectro-Polarimeter (ViSP) of the NSF Daniel K. Inouye Solar Telescope (DKIST) collected its Science Verification data on May 7-8, 2021. The instrument observed multiple layers of a sunspot atmosphere simultaneously, in passbands of Ca-II 397 nm (H-line), Fe-I 630 nm, and Ca-II 854 nm, scanning the region with a spatial sampling of 0.041" and average temporal cadence of 7.76 seconds, for a 38.8 minute duration. The slit moves southward across the plane-of-the-sky at 3.83 km/s. The spectropolarimetric scans exhibit prominent oscillatory 'ridge' structures which lie nearly perpendicular to the direction of slit motion (north to south). These ridges are visible in maps of line intensity, central wavelength, line width, and both linear and circular polarizations. Contemporaneous Atmospheric Imaging Assembly observations indicate these ridges are purely temporal in character and likely attributed to the familiar chromospheric 3-minute umbral oscillations. We observe in detail a steady umbral flash near the center of the sunspot umbra. Although bad seeing limited the spatial resolution, the unique high signal-to-noise enable us to estimate the shock Mach numbers (= 2), propagation speeds (= 9 km/s), and their impact on longitudinal magnetic field (delta B = 50 G), gas pressure, and temperature (delta T/T = 0.1) of the subshocks over 30 seconds. We also find evidence for rarefaction waves situated between neighboring wave-train shocks. The Ca-II 854 nm line width is steady throughout the umbral flash except for a sharp 1.5 km/s dip immediately before, and comparable spike immediately after, the passage of the shock front. This zig-zag in line width is centered on the subshock and extends over 0.4".
description: 11 pages, 5 figures, accepted for publication to ApJ Letters (February 2023)
SELECTION OF SKIP-LOT SAMPLING PLAN OF TYPE SkSP-T USING SPECIAL TYPE DOUBLE SAMPLING PLAN AS REFERENCE PLAN BASED ON FUZZY LOGIC TECHNIQUES USING R PROGRAMMING LANGUAGE
Creators: name: S. Suganya
name: K. Pradeepa Veerakumari
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Fuzzy logic
FOC band
incoming and outgoing quality levels
STDSP
SkSP-T

description: This paper justify the scheming technique of new system of skip-lot sampling plan of type SkSP-T with Special type Double Sampling plan as Reference plan Using Fuzzy Logic Techniques. The designing methodology includes the evaluation of Acceptable Quality Level, Limiting Quality Level, Operating ratio and the Operating Characteristic (OC) Curves are constructed for using various Fuzzy parametric values. Also draw the Fuzzy OC Band for new proposed plan. FOC band specify the fuzzy probability of acceptance value with corresponding fraction of nonconforming items of this sampling plan.
Sensitivity and Economic Analysis of an Insured System with Extended Conditional Warranty
Creators: name: Sachdeva, Kajal
name: Taneja, Gulshan
name: Manocha, Amit
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Extended Conditional Warranty
Sensitivity Analysis
Profit
Insurance Cover

description: Warranty and insurance are equally essential for a technological system to cover repair/replacement costs of all types of losses, i.e., natural wear/tear or unexpected external force/accidents. This paper examines the sensitivity and profitability of a stochastic model whose defects may cover under conditional warranty/insurance. The system user may extend the warranty period by paying an additional price. As a result, the system functions in normal warranty, extended warranty, and during non-warranty periods. If a system fault occurred is covered under warranty conditions, the manufacturer is responsible for all repair/replacement costs during normal/extended warranty which otherwise are paid by the insurance provider if covered under an insurance claim, or else, the user is responsible for the entire cost when coverage of fault neither falls in warranty conditions nor under the insurance policy. Using Markov and the regenerative process, various measures of system effectiveness associated with the profit of the user and the manufacturer are examined. Relative sensitivity analysis of the profit function and availability has been performed for all periods.
Self-complementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured Femur
Creators: name: Awad, Hani A
name: Reynolds, David G
name: Samulski, R Jude
name: O'Keefe, Regis J
name: Spilker, Mark
name: Yazici, Cemal
name: Beecham, E Jeffrey
name: Samulski, Jade
name: Schwarz, Edward M
name: Gertzman, Arthur A
name: Zhang, Xinping
name: Takahata, Masahiko
name: Xie, Chao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Structural allografts used for critical bone defects have limited osteogenic properties for biointegration. Although ex vivo tissue-engineered constructs expressing bone morphogenetic protein-2 (BMP2) have demonstrated efficacy in critical defect models, similar success has not been achieved with off-the-shelf acellular approaches, including allografts coated with freeze-dried single-stranded adeno-associated virus (ssAAV-BMP2). To see whether the self-complementary AAV serotype 2.5 vector (scAAV2.5-BMP2) could overcome this, we performed side-by-side comparisons in vitro and in the murine femoral allograft model. Although ssAAV-BMP2 was unable to induce BMP2 expression and differentiation of C3H10T1/2 cells in culture, scAAV2.5-BMP2 transduction led to dose-dependent BMP2 expression and alkaline phosphatase activity, and displayed a 25-fold increased transduction efficiency in vivo. After 6 weeks, the ssAAV-BMP2 coating failed to demonstrate any significant effects. However, all allografts coated with 1010 scAAV2.5-BMP2 formed a new cortical shell that was indistinguishable to that formed by live autografts. Additionally, coated allografts experienced reduced resorption resulting in a threefold increase in graft bone volume versus autograft. This led to biomechanical superiority versus both allografts and autografts, and equivalent torsional rigidity to unfractured femur. Collectively, these results demonstrate that scAAV2.5-BMP2 coating overcomes the major limitations of structural allografts, which can be used to heal critical defects of any size.
Single Server Retrial Queueing System with Catastrophe
Creators: name: Singla, Neelam
name: Ankita Garg
Publisher: name: Reliability: Theory & Applications
Year: 2022
Subjects: Queueing
Retrial
Catastrophe
Repair

description: The present paper analyses a retrial queueing system with Catastrophe. Primary and secondary customers follow Poisson processes. Inter arrival and service times are Exponentially distributed. Catastrophe occurs on a busy server and follows Poisson process. The server is sent for repair after its failure. The repair times are also Exponentially distributed. Steady state and time dependent solutions for number of customers in the system when the server is idle or busy are obtained. The probability of the server being under repair is obtained. Some performance measures are also evaluated. Numerical results are obtained and represented graphically.