cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lithium protects motor neurons at prolonged time intervals in a single knock out double transgenic mouse model of spinal muscle atrophy
Creators: name: Fulceri, Federica
name: Guagnozzi, Mariangela
name: Matarangasi, Antuela
name: Pasquali, Livia
name: Siciliano, Gabriele
name: Paparelli, Antonio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: SMA; SMN; lithium; motor neuron degeneration

description: In the present study, we profited from a slow progressive model of motor neuron death in a knock out double transgenic mouse model (SMN2+/+; Smn-/-; SMN1A2G+/-) of Spinal Muscle Atrophy type III (SMA III) to evaluate the protective effects of lithium. In detail, disease progression was evaluated up to 535 days of age and lithium was administered for 455 days. During this time interval motor behaviour was constantly monitored. The spinal cords were analyzed both at light and electron microscopy. The levels of the survival motor neuron protein (SMN) were quantified by Western blotting cord homogenates. We found that lithium was effective to prevent motor decay and fully protected motor neuron loss as well as motor neuron size variations. In the anterior white matter lithium induced a decrease in the radial-like gliosis. These findings were substantiated by an in depth analysis at electron microscopy. These effects were accompanied by a dramatic increase of the SMN protein measured by immunoblotting the whole spinal cord. When observed in situ SMN appeared to be localized in various cell types. When counted by ultrastructural morphometry motor neuron levels of SMN were dramatically increased under the influence of lithium. Interestingly, the effects induced by lithium in the spinal cord and specifically within motor neurons were also described in wild types (in the absence of motor neuron degeneration). These data demonstrate that lithium might be effective in counteracting the disease process occurring in spinal muscle atrophy while it appears to be by far the most effective compound to increase the levels of the key protein SMN. These effects might be due both to the inhibition of GSK3beta and inositol monophosphate phosphatase thus influencing in turn the wnt and the autophagy pathways.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
The fibrillar crimps of the sclera
Creators: name: Raspanti, Mario
name: Reguzzoni, Marcella
name: Congiu, Terenzio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Tendon; sclera; extracellular matrix

description: Crimps are a typical feature of tendons and of some ligaments where they are responsible for the non-linear behaviour of the tissue at low strain values. Previous studies (Raspanti et al., 2005) shown that in tendons these visible crimps always correspond to a distinctive buckling and/or left-handed torsion of the collagen fibrils, subsequently named “fibrillar crimp” (Franchi et al, 2007). These planar crimps are exclusive of the collagen fibrils of tendons and ligaments, whose subfibrils run straight and parallel and tend to behave like stiff rods; by contrast, the collagen fibrils of most tissues, which are sometimes defined as “reticular fibrils” of “type III fibrils” and whose subfibrils follow an helical course, are almost infinitely flexible and can withstand even sharp U-turns without buckling. In the present study we investigated the rat sclera, whose ultrastructure is closely related to that of tendons and ligaments (Raspanti et al., 1992). The tissue was observed by light microscopy, high-resolution scanning electron microscopy and atomic force microscopy. The sclera appears made of flattened fascicles of large and heterogeneous collagen fibrils, running in all directions and often following a wavy course. The individual fascicles are identical in structure and appearance to those of tendon, as are the numerous crimps which can be easily observed along their fibrils. The presence of crimps in the sclera cannot be taken for granted because at variance with tendon, which is subject to intermittent load/recoil cycles, this tissue is held under continuous tension by the intraocular pressure (IOP). A typical intra-ocular pressure of 20-30 mmHg would induce in the rat sclera a tension varying from 50 to 80 kN/m2, and the elastic behaviour of the crimps may have a role in maintaining the shape of the eyeball. The crimps may therefore be fully functional, confirming this tissue as a sort of hemispherical tendon.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ¾ÑÑÐ°Ð²Ð¾Ð² Ð¥Ð¢Ð¡ ÑÐ¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð ÐµÐ·Ð¾Ð»-Ð¡Ð2 Ð¿ÑÐ¾ÑÐµÑÑÐ°
title: Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð¡ÐµÑÐ³ÐµÐµÐ², ÐÐ²Ð³ÐµÐ½Ð¸Ð¹ ÐÐµÐ½Ð½Ð°Ð´ÑÐµÐ²Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ
ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ¾ÑÑÐ°Ð²Ð¾Ð² Ð¥Ð¢Ð¡
Ð¿ÑÐ¾ÑÐµÑÑ

description: Ð Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÐ¾ÑÑÐ°Ð²Ñ Ð¥Ð¢Ð¡ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð ÐµÐ·Ð¾Ð»-Ð¡Ð2 Ð¿ÑÐ¾ÑÐµÑÑÐ°. ÐÐ· Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÑ Ð² ÑÐ°Ð±Ð¾ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² ÑÐ»ÐµÐ´ÑÐµÑ, ÑÑÐ¾ Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ðµ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ðµ Ð¸Ð¼ÐµÐµÑ, Ð¿Ð¾-Ð²Ð¸Ð´Ð¸Ð¼Ð¾Ð¼Ñ, ÑÐ¾Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ðµ Â«ÑÐ¼Ð¾Ð»Ð° - Ð³Ð»Ð¸Ð½Ð¸ÑÑÐ°Ñ - ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ°Â», Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ ÑÑÐµÐ´Ð½Ð¸Ð¹ ÑÐ°Ð·Ð¼ÐµÑ Ð·ÐµÑÐ½Ð°. ÐÐ»Ñ ÐºÑÑÐ¿Ð½ÑÑ Ð¿ÐµÑÐºÐ¾Ð² (03) ÑÑÐµÐ±ÑÐµÑÑÑ Ð¼ÐµÐ½ÑÑÐµ Ð´Ð¾Ð±Ð°Ð²ÐºÐ¸. ÐÐ·Ð±ÑÑÐ¾Ðº Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ° (Ð¾Ð½ Ð½Ðµ Ð·Ð°ÑÐ²ÐµÑÐ´ÐµÐ²Ð°ÐµÑ) Ð²ÑÐ·ÑÐ²Ð°ÐµÑ, Ð¾ÑÐµÐ²Ð¸Ð´Ð½Ð¾, Ð½ÐµÐºÐ¾ÑÐ¾ÑÐ¾Ðµ Â«ÑÐºÐ¾Ð»ÑÐ¶ÐµÐ½Ð¸ÐµÂ» Ð¼ÐµÐ¶Ð´Ñ ÑÐ°ÑÑÐ¸ÑÐ°Ð¼Ð¸ Ð¸, ÐºÐ°Ðº ÑÐ»ÐµÐ´ÑÑÐ²Ð¸Ðµ, ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð´Ð»Ñ Ð½Ð°Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÐµÐ¹ Ñ Ð¼Ð°Ð»ÑÐ¼ (Ð´Ð¾ 0,5%) ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ Ð³Ð»Ð¸Ð½Ð¸ÑÑÐ¾Ð¹. Ð¡ Ð´ÑÑÐ³Ð¾Ð¹ ÑÑÐ¾ÑÐ¾Ð½Ñ Ð² Ð¿ÐµÑÐºÐ°Ñ Ñ Ð²ÑÑÐ¾ÐºÐ¾Ð¹ Ð³Ð»Ð¸Ð½Ð¸ÑÑÐ¾Ð¹ (1,2;1,7%) Ð¸Ð·Ð±ÑÑÐ¾Ðº Ð´Ð¾Ð±Ð°Ð²ÐºÐ¸ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ. ÐÐ½Ð° ÑÐ²ÑÐ·ÑÐ²Ð°ÐµÑ Ð³Ð»Ð¸Ð½Ð¸ÑÑÑÑ Ñ. Ðµ. Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð´Ð¸Ñ Ð¿Ð¾ ÑÑÑÐµÑÑÐ²Ñ Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ñ Ð½Ð°Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»Ñ. ÐÑÐ¸ ÑÑÐ¾Ð¼ Ð¿ÑÐ¾ÑÐ½Ð¾ÑÑÑ Ñ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ° Ð¼Ð¾Ð½Ð¾ÑÐ¾Ð½Ð½Ð¾ ÑÐ°ÑÑÐµÑ, Ð½Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐ¸Ð²Ð°ÐµÑÑÑ Ð¸ Ð²ÑÐ·ÐºÐ¾ÑÑÑ ÑÐ¼ÐµÑÐ¸, ÑÑÐ¾ Ð¿ÑÐ¸ Ð±Ð¾Ð»ÑÑÐ¾Ð¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ð¸ (0,8-1,0%) ÑÑÑÐ´ÑÐ°ÐµÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°. ÐÑÐ¾Ð¼Ðµ ÑÐ¾Ð³Ð¾ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð¥Ð¢Ð¡ Ñ Ð¿ÐµÑÐºÐ°Ð¼Ð¸, Ð¸Ð¼ÐµÑÑÐ¸Ð¼Ð¸ Ð±Ð¾Ð»ÑÑÑÑ Ð³Ð»Ð¸Ð½Ð¸ÑÑÑÑ Ð½Ð¸Ð¶Ðµ.
A Model of Fermion Masses and Mixings Triggered by Family Problem in Warped Extra Dimensions
Creators: name: Guo, Zhi-Qiang
name: Ma, Bo-Qiang
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We suggest a model which addresses both the fermion mass hierarchy problem and the family problem in two-layer warped extra dimensions. In this model, 3 family fermions in 4 dimensions (4D) generate from 1 family in two-layer warped 6D by two step Kluza-Klein decompositions. The mass hierarchies are produced by the exponential behavior of 4D fermion zero mode profiles. The mixings and masses of fermions are closely related to the family problem. By adjusting parameters in this model, the numerical results can be very close to the experimental data both in the quark sector and in the lepton sector. In the lepton sector, we suppose neutrinos to be Dirac ones. The neutrino masses of sub-$\mathrm{eV}$ scale are obtained, and also CP violation emerges in the lepton sector.
description: 49 latex pages, 1 figure, final version in journal publication
In vitro biocompatibility of a new PVP-Hydrogel
Creators: name: Zeka, Keti
name: Coppa, Paola
name: Corsi, Leo
name: Pajewski, Leonardo A.
name: Vegliò, Francesco
name: Continenza, Maria A.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: PVP-hydrogel; biomaterials; difficult wounds; in vitro biocompatibility

description: These experiments show the in vitro biocompatibility of a new PVP-Hydrogel comparing it with Neoheal, an already experimented biomaterial completely biocompatible. The new hydrogel consists of three polymers - Polyvinyl pyrrolidone (PVP), Agar and Polyethylene glycol (PEG) - mixed, reticulated and at the same time sterilized by gamma irradiation at 25 kGy. The target clinical applications of this new biomaterial are the “difficult wounds”. For the in vitro experimental protocol, it was used a primary culture of fibroblasts taken from the subcutaneous tissue of a newborn mice, seeding the cells on a little square (1cm2 area) of both kinds of hydrogel. As the ISO protocol prescribes, the experiments were repeated 3 times for each kind of hydrogel, stopping the culture at the 3rd, 7th and 14th day after the seeding. For all steps, three Petri dishes were used as controls without biomaterials. At each fixed deadline, all Petri dishes were colored using the Wright method for cell counting and other morphological evaluations. The microscopic analysis revealed the complete biocompatibility of both hydrogels at every step of the experiment and the test produced very interesting results. The new PVP-Hydrogel was found to be more adsorbent, increasing its dimensions day by day and free floating in the medium. The Neoheal, indeed, revealed more sticky properties, adhering to the dish floor but neither swelling nor increasing its volume. These different chemical properties caused a very different behavior of the cells that could grow very well on and under the PVP-Hydrogel, but not on or under the Neoheal. These results showed that the new PVP-hydrogel is biocompatible with the cells just like the Neoheal, even if in a very different way. Other experiments have to complete the protocol to test the biodegradation and the biocompatibility in vivo of both biomaterials, when they enter in contact with the tissues.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Altered levels of IL-18 in sera of autism patients as well as in reeler brain
Creators: name: Businaro, Rita
name: Fuso, Andrea
name: Laviola, Giovanni
name: Azzara, Gabriella
name: Cannizzaro, Cristina
name: Corsi, Mariangela
name: Massoni, Francesco
name: Onofri, Emanuela
name: Ricci, Pasquale
name: Ricci, Serafino
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with onset in the first 3 years of life, with an incidence in Italy of 6–10 new cases per 10,000 children per year. Affected children show impaired social interactions, repetitive or stereotypical behaviors and interests. Disruption/dysregulation of neuroimmune functioning, whether expressed in the patient or during the course of the individual’s brain development, are implicated in Idiopathic ASD (1). Quantitative and qualitative differences in immune function between children with ASD and typically developing controls have been demonstrated, including evidence for increased neuroinflammation and cytokine production in brain specimens obtained from individuals with ASD(2). Peripheral innate immune activation is starting to be recognized as a prominent feature of diseases affecting the central nervous system.(3) In a recent study we have shown that elevated levels of the pro-inflammatory cytokines including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-alpha and BDNF were present in sera of autistic patients (4).We have recently observed that the levels of IL-18 detected in the sera of autistic children were rather lower than those measured in the sera of matched healthy children. We decided to inquire if an alteration in the amount of IL-18 in different areas of the CNS and in the serum was also detectable in Reeler eterozygous mice, a mouse model of autism, compared to wild type mice. IL-18 was localized in different brain regions by immunohistochemistry and in whole brain homogenates by western blots. Quantitative analysis of the cytokine in serum was performed by ELISA.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Controlling the onset of traveling pulses in excitable media by nonlocal spatial coupling and time-delayed feedback
Creators: name: Schneider, Felix M.
name: Schoell, Eckehard
name: Dahlem, Markus A.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: The onset of pulse propagation is studied in a reaction-diffusion (RD) model with control by augmented transmission capability that is provided either along nonlocal spatial coupling or by time-delayed feedback. We show that traveling pulses occur primarily as solutions to the RD equations while augmented transmission changes excitability. For certain ranges of the parameter settings, defined as weak susceptibility and moderate control, respectively, the hybrid model can be mapped to the original RD model. This results in an effective change of RD parameters controlled by augmented transmission. Outside moderate control parameter settings new patterns are obtained, for example step-wise propagation due to delay-induced oscillations. Augmented transmission constitutes a signaling system complementary to the classical RD mechanism of pattern formation. Our hybrid model combines the two major signaling systems in the brain, namely volume transmission and synaptic transmission. Our results provide insights into the spread and control of pathological pulses in the brain.
Additional file 1 of Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells
Creators: name: Lee, Hong
name: Jeong, Sang Hoon
name: Lee, Hyejin
name: Kim, Cherry
name: Nam, Yoon Jeong
name: Kang, Ja Young
name: Song, Myeong Ok
name: Choi, Jin Young
name: Kim, Jaeyoung
name: Park, Eun-Kee
name: Baek, Yong-Wook
name: Lee, Ju-Han
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 1. Supplementary Figure 1. Clinical significance of selected genes in patient with lung adenocarcinoma.
Sarcoglycans in cerebral cortex of the rat: an immunohistochemical and molecular study
Creators: name: Anastasi, Giuseppe
name: Tomasello, Francesco
name: Aguennouz, M’hammed
name: Conti, Alfredo
name: Vermiglio, Giovanna
name: Vaccarino, Gianluigi
name: Bramanti, Placido
name: Cutroneo, Giuseppina
name: Crisafulli, Costantino
name: Barresi, Valeria
name: Vita, Giuseppe
name: Barresi, Gaetano
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Sarcoglycan; Cerebral cortex; Western blot; Immunoperoxidase; Immunohistochemistry

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
CP violation in sbottom decays
Creators: name: Deppisch, Frank F.
name: Kittel, Olaf
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study CP asymmetries in two-body decays of bottom squarks into charginos and tops. These asymmetries probe the SUSY CP phases of the sbottom and the chargino sector in the Minimal Supersymmetric Standard Model. We identify the MSSM parameter space where the CP asymmetries are sizeable, and analyze the feasibility of their observation at the LHC. As a result, potentially detectable CP asymmetries in sbottom decays are found, which motivates further detailed experimental studies for probing the SUSY CP phases.
description: 29 pages, 7 figures
Additional file 7 of A multi-center, single-arm, phase II study of anlotinib plus paclitaxel and cisplatin as the first-line therapy of recurrent/advanced esophageal squamous cell carcinoma
Creators: name: Li, Ning
name: Wu, Tao
name: Hong, Yong-Gui
name: Guo, Yan-Zhen
name: Cheng, Yu-Feng
name: Ma, Yi-Jie
name: Bie, Liang-Yu
name: Cui, Dong-Hai
name: Gao, Xiao-Hui
name: Tan, Bing-Xu
name: Li, Bao-Sheng
name: Luo, Su-Xia
name: Wang, Jun-Sheng
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 7: Table S5. Patients who achieved complete response (n = 4)
title: ÐÐ±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð² XXI Ð²ÐµÐºÐµ
title: An Individualâs Education in the 21st Century
Creators: name: ÐÐ¾Ð³Ð´Ð°Ð½Ð¾Ð², Ð¡ÐµÑÐ³ÐµÐ¹
name: ÐÐ¾Ð½Ð°ÑÐ¾Ð², ÐÐ°Ð»ÐµÑÐ¸Ð¹
name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½ÑÐ¹ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ¾ÑÑÐ¼ (2018; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³). Ð¡ÐµÐºÑÐ¸Ñ "ÐÐ·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ ÐºÐ°ÑÐµÐ´Ñ Ð®ÐÐÐ¡ÐÐ Ð¿Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÐºÐ°ÑÐµÑÑÐ²Ð¾Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² Ð¸Ð½ÑÐµÑÐµÑÐ°Ñ  ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾Ð³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ"
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2018

description: Ð ÑÑÐ°ÑÑÐµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÑÑ ÑÑÐµÐ½Ð´Ñ, Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÑÑÑÐ¸Ðµ ÑÐ°Ð´Ð¸ÐºÐ°Ð»ÑÐ½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾-ÐºÑÐ»ÑÑÑÑÐ½Ð¾Ð¹ Ð¸ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÑÐµÑÐ°Ñ Ð¶Ð¸Ð·Ð½Ð¸ Ð¾Ð±ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐ²ÑÑ Ð´Ð²ÑÑ Ð´ÐµÑÑÑÐ¸Ð»ÐµÑÐ¸Ð¹ XXI Ð²ÐµÐºÐ° Ð¸ Ð¿ÑÐ¾ÑÐ»ÐµÐ¶Ð¸Ð²Ð°ÐµÑÑÑ Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐµÐ¾ÑÐµÑÐ¸ÐºÐ¾-Ð¼ÐµÑÐ¾Ð´Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð² Ðº Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¼ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐµ.
description: Abstract: The article examines the trends that determine radical changes in the sociocultural and economic spheres of society in the first two decades of the 21st century, and their influence on the change in theoretical, methodological and practical approaches to the organization and content of education in a modern university is traced.
Leveraging User Simulation to Develop and Evaluate Conversational Information Access Agents
Creators: name: Bernard, Nolwenn
Publisher: name: arXiv
Year: 2023
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: We observe a change in the way users access information, that is, the rise of conversational information access (CIA) agents. However, the automatic evaluation of these agents remains an open challenge. Moreover, the training of CIA agents is cumbersome as it mostly relies on conversational corpora, expert knowledge, and reinforcement learning. User simulation has been identified as a promising solution to tackle automatic evaluation and has been previously used in reinforcement learning. In this research, we investigate how user simulation can be leveraged in the context of CIA. We organize the work in three parts. We begin with the identification of requirements for user simulators for training and evaluating CIA agents and compare existing types of simulator regarding these. Then, we plan to combine these different types of simulators into a new hybrid simulator. Finally, we aim to extend simulators to handle more complex information seeking scenarios.
description: Proceedings of the 17th ACM International Conference on Web Search and Data Mining (WSDM '24), 2024
An immunohistochemical study of sarcoglycan subcomplex on normal and pathological breast
Creators: name: Arco, Alba
name: Gioffrè, Mara
name: Inferrera, Marco
name: Favaloro, Angelo
name: Speciale, Francesco
name: Murabito, Letizia
name: Bruschetta, Daniele
name: Magaudda, Ludovico
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Breast; sarcoglycan; epithelium; immunohistochemistry

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
The transverse shift of a high order paraxial vortex-beam induced by a homogeneous anisotropic medium
Creators: name: Fadeyeva, T. A.
name: Rubass, A. F.
name: Volyar, A. V.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We consider the propagation of a tilted high order paraxial vortex-beam through a homogeneous anisotropic medium of a uniaxial crystal. We found that the initially circularly polarized beam bearing the l-order optical vortex splits into ordinary and extraordinary beams with a complex vortex structure. After a series of dislocation reactions the vortices gather together at the axis of the partial beam with the initial circular polarization shaping the l-order optical vortex. However, only l-1 vortices gather together on the axis of the partial beam with the orthogonal circular polarization. One optical vortex is shifted along the direction perpendicular to the inclination plane of the beam. Such a vortex displacement induces the transverse shift of the partial beam. In fact, we deal with the beam quadrefringence in a uniaxial, homogeneous anisotropic medium. The first two beams is a result of the splitting of the initial tilted beam into the ordinary and extraordinary once.
description: 14 pages, 19 figures
Effects of antioxidants on CSE-induced cell death in human asthmatic primary bronchial epithelial cells
Creators: name: Bucchieri, Fabio
name: Cappello, Francesco
name: David, Sabrina
name: Noto, Antonio
name: Marino Gammazza, Antonella
name: Pitruzzella, Alessandro
name: Rizzuto, Luigi
name: Fucarino, Alberto
name: Holgate, Stephen T.
name: Davies, Donna E.
name: Zummo, Giovanni
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Bronchial epithelium; asthma; cigarette smoke; oxidative stress

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Additional file 8 of A multi-center, single-arm, phase II study of anlotinib plus paclitaxel and cisplatin as the first-line therapy of recurrent/advanced esophageal squamous cell carcinoma
Creators: name: Li, Ning
name: Wu, Tao
name: Hong, Yong-Gui
name: Guo, Yan-Zhen
name: Cheng, Yu-Feng
name: Ma, Yi-Jie
name: Bie, Liang-Yu
name: Cui, Dong-Hai
name: Gao, Xiao-Hui
name: Tan, Bing-Xu
name: Li, Bao-Sheng
name: Luo, Su-Xia
name: Wang, Jun-Sheng
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 8: Table S6. Subgroup analysis of the relation between clinical factors and progression-free survival (PFS)
Organic cation transporter 2 mRNA expression in dorsal root ganglia neurons
Creators: name: Cavalletti, Guido
name: Nicolini, Gabriella
name: Ceresa, Cecilia
name: Oggioni, Norberto
name: Sala, Barbara
name: Rigolio, Roberta
name: Chiorazzi, Alessia
name: Tredici, Giovanni
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Organic cation transporter; dorsal root ganglia neurons; developmental expression

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
title: ÐÐµÐ¸Ð´ÐµÐ°Ð»ÑÐ½Ð¾ÑÑÑ ÑÐ²ÑÐ·ÐµÐ¹ Ð¸ Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° ÑÐ¿Ð»Ð¾ÑÐ½ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ½Ñ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ Ñ Ð²Ð½ÐµÑÐ½Ð¸Ð¼ Ð¿Ð¾Ð´Ð²Ð¾Ð´Ð¾Ð¼ ÑÐµÐ¿Ð»Ð¾ÑÑ Ñ Ð±ÐµÑÑÐ°ÑÑÐ½Ð½ÑÐ¼ ÑÐ¸Ð»Ð¾Ð²ÑÐ¼ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð¼
title: Ð°Ð²ÑÐ¾ÑÐµÑ. Ð´Ð¸Ñ. â¦ ÐºÐ°Ð½Ð´. ÑÐµÑ Ð½. Ð½Ð°ÑÐº: 05.02.02
titleType: Subtitle
Creators: name: ÐÐ²Ð¾ÑÑÐ¾Ð², ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÐ¾ÑÑÐ½Ð¸ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»ÐµÐ¹ Ð²Ð½ÑÑÑÐµÐ½Ð½ÐµÐ³Ð¾ ÑÐ³Ð¾ÑÐ°Ð½Ð¸Ñ
Ð£Ð¿Ð»Ð¾ÑÐ½Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ð¿ÑÐ¾ÐºÐ»Ð°Ð´ÐºÐ¸

description: Ð Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð²Ð¾Ð¿ÑÐ¾ÑÑ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð´ÐµÐ¹ÑÑÐ²ÑÑÑÐ¸Ñ ÑÐ¸Ð» Ð½Ð° ÑÐ¿Ð»Ð¾ÑÐ½ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ½Ñ Ð¸ Ð´ÐµÑÐ°Ð»Ð¸ Ð±ÐµÑÑÐ°ÑÑÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð° Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ Ñ Ð²Ð½ÐµÑÐ½Ð¸Ð¼ Ð¿Ð¾Ð´Ð²Ð¾Ð´Ð¾Ð¼ ÑÐµÐ¿Ð»Ð¾ÑÑ. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð° ÑÑÐµÐ¿ÐµÐ½Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð°, Ð¿ÑÐ¸Ð²Ð¾Ð´ÑÑÐµÐ³Ð¾ Ð² Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ðµ Ð¿Ð¾ÑÑÐµÐ½Ñ, Ð½Ð° ÑÑÐ»Ð¾Ð²Ð¸Ñ ÑÐ°Ð±Ð¾ÑÑ Ð¿Ð¾ÑÑÐ½ÐµÐ²ÑÑ ÑÐ¿Ð»Ð¾ÑÐ½ÐµÐ½Ð¸Ð¹. ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½ Ð¼ÐµÑÐ¾Ð´ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ ÑÑÐºÐ¾ÑÐµÐ½Ð¸Ð¹ Ð´Ð¾ +/- 200 g Ð¸ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ½Ð°Ñ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¿Ð¾Ð´Ð±Ð¾ÑÐ° Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð¿Ð¾ÑÑÐ½ÐµÐ²ÑÑ ÑÐ¿Ð»Ð¾ÑÐ½ÐµÐ½Ð¸Ð¹.
Stemness features in peritumor tissue of glioblastoma
Creators: name: Lama, Gina
name: Proietti, Gabriella
name: Mangiola, Annunziato
name: Colabianchi, Anna
name: De Bonis, Pasquale
name: Lauriola, Libero
name: Maira, Giulio
name: Sica, Gigliola
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Nestin; NG2; GD3; CD105; glioblastoma; peritumor tissue

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
The Planetary Nebula Luminosity Function: Pieces of the Puzzle
Creators: name: Ciardullo, Robin
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Extragalactic surveys in the emission line of [O III] 5007 have provided us with the absolute line strengths of large, homogeneous sets of planetary nebulae. These data have been used to address a host of problems, from the measurement of the extragalactic distance scale, to the study of stellar populations. I review our current understanding of the [O III] planetary nebula luminosity function (PNLF), and discuss some of the physical processes that effect its structure. I also describe the features of the H-alpha PNLF, a function that, upon first glance, looks similar to the [O III] PNLF, but which includes a very different set of objects. Finally, I discuss recent measurements of alpha, the number of PNe found in a stellar population, normalized to that population's bolometric luminosity. I show that, contrary to expectations, the values of alpha found in actively star-forming spirals is essentially the same as those measured in late-type elliptical and lenticular systems. I discuss how this result sheds light on the physics of the planetary nebula phenomenon.
description: 7 pages, including 7 figures; presentation at the workshop on the Legacies of the Macquarie/AAO/Strasbourg H-alpha Planetary Nebula project, accepted for publication in PASA
Mean field approximation for noisy delay coupled excitable neurons
Creators: name: Buric, Nikola
name: Rankovic, Dragana
name: Todorovic, Kristina
name: Vasovic, Nebojsa
Publisher: name: arXiv
Year: 2010
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Mean field approximation of a large collection of FitzHugh-Nagumo excitable neurons with noise and all-to-all coupling with explicit time-delays, modelled by $N\gg 1$ stochastic delay-differential equations is derived. The resulting approximation contains only two deterministic delay-differential equations but provides excellent predictions concerning the stability and bifurcations of the averaged global variables of the exact large system.
description: 15 pages, 3 figures
Effect of higher borides and inhomogeneity of oxygen distribution on critical current density of undoped and doped magnesium diboride
Creators: name: Prikhna, T. A.
name: Gawalek, W.
name: Tkach, V. M.
name: Danilenko, N. I.
name: Savchuk, Ya M.
name: Dub, S. N.
name: Moshchil, V. E.
name: Kozyrev, A. V.
name: Sergienko, N. V.
name: Wendt, M.
name: Melnikov, V. S.
name: Dellith, J.
name: Weber, H
name: Eisterer, M
name: Schmidt, Ch
name: Habisreuther, T
name: Litzkendorf, D
name: Vajda, J
name: Shapovalov, A. P.
name: Sokolovsky, V.
name: Nagorny, P. A.
name: Sverdun, V. B.
name: Kosa, J.
name: Karau, F.
name: Starostina, A. V.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The effect of doping with Ti, Ta, SiC in complex with synthesis temperature on the amount and distribution of structural inhomogeneities in MgB2 matrix of high-pressuresynthesized-materials (2 GPa) which can influence pining: higher borides (MgB12) and oxygen-enriched Mg-B-O inclusions, was established and a mechanism of doping effect on jc increase different from the generally accepted was proposed. Near theoretically dense SiC-doped material exhibited jc= 1000000 A/sq. cm in 1T field and Hirr =8.5 T at 20 K. The highest jc in fields above 9, 6, and 4 T at 10, 20, and 25 K, respectively, was demonstrated by materials synthesized at 2 GPa, 600 oC from Mg and B without additions (at 20 K jc= 100 A/sq. cm in 10 T field). Materials synthesized from Mg and B taken up to 1:20 ratio were superconductive. The highest jc (60000 A/sq. cm at 20 K in zero field, Hirr= 5 T) and the amount of SC phase (95.3 percents of shielding fraction), Tc being 37 K were demonstrated by materials having near MgB12 composition of the matrix. The materials with MgB12 matrix had a doubled microhardness of that with MgB2 matrix (25 GPa and 13.08 GPa, at a load of 4.9 N, respectively).
description: 14 pages, 11 figues, 2 tables, presented at EUCAS 2009, submitted to Journal of Physics: Conference Series, 2009
title: Английский язык для химических специальностей
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2025

description: В учебном пособии даны тексты, позволяющие изучить специализированную профессиональную англоязычную терминологию. Рассмотрены химия как наука, понятия «химический элемент», «химическая реакция», «химическое вещество». Представлены технологии производства таких продуктов химической отрасли как краски, лаки, полимеры, описаны сущность хроматографии, экологические аспекты химической отрасли и т.д. В конце каждой главы даны упражнения для закрепления изученной темы. Учебное пособие предназначено для студентов укрупненной группы специальностей и профессий среднего профессионального образования «Химические технологии», изучающих дисциплину «Иностранный язык (английский)».
title: ÐÐ¿ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÐµ Ð¿ÐµÑÐµÐºÐ»ÑÑÐµÐ½Ð¸Ñ Ð² ÑÐ»ÐµÐºÑÑÐ¾ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ°Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ð¹ Ð¸ Ð¿Ð¾Ð´ÑÑÐ°Ð½ÑÐ¸Ð¹
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ°Ð¿Ð¸Ð´ÑÑ, ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
name: Ð¡ÐµÐ¼ÐµÐ½Ð¾Ð², ÐÐ¾Ð½ÑÑÐ°Ð½ÑÐ¸Ð½
name: Ð¡Ð¾Ð»Ð¾Ð²ÑÐµÐ²Ð°, Ð¡Ð²ÐµÑÐ»Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÑÐ°Ð½ÑÐ¸Ð¸
Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ¸
ÐÐ¾Ð¼Ð¼ÑÑÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÑÑÐ°
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description: Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ð¼Ñ ÑÑÐ°Ð½Ð´Ð°ÑÑÑ Ð²ÑÑÑÐµÐ³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¤ÐµÐ´ÐµÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð°Ð²ÑÐ¾Ð½Ð¾Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÑÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ Ð²ÑÑÑÐµÐ³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Â«Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾Â» Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ¾Ð² 13.03.02 Â«Ð­Ð»ÐµÐºÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÐºÐ° Ð¸ ÑÐ»ÐµÐºÑÑÐ¾ÑÐµÑÐ½Ð¸ÐºÐ°Â», Ð¿Ð¾ Ð´Ð¸ÑÑÐ¸Ð¿Ð»Ð¸Ð½Ð°Ð¼ Â«Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÑÐ°Ð½ÑÐ¸Ð¸ Ð¸ Ð¿Ð¾Ð´ÑÑÐ°Ð½ÑÐ¸Ð¸Â», Â«Ð ÐµÐ¶Ð¸Ð¼Ñ ÑÐ°Ð±Ð¾ÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ð¹ Ð¸ Ð¿Ð¾Ð´ÑÑÐ°Ð½ÑÐ¸Ð¹Â».
Ð Ð°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÑÑ Ð¿ÑÐ°Ð²Ð¸Ð»Ð° Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð¿ÐµÑÐµÐºÐ»ÑÑÐµÐ½Ð¸Ð¹ Ð² ÑÐ»ÐµÐºÑÑÐ¾ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ°Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ð¹ Ð¸ Ð¿Ð¾Ð´ÑÑÐ°Ð½ÑÐ¸Ð¹. Ð Ð°ÑÐºÑÑÐ²Ð°ÑÑÑÑ Ð¿ÑÐ¸ÑÐ¸Ð½Ñ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÑÐ´ÐºÐ° Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð¹ ÐºÐ¾Ð¼Ð¼ÑÑÐ°ÑÐ¸Ð¾Ð½Ð½ÑÐ¼Ð¸ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ°Ð¼Ð¸. ÐÑÐ²ÐµÑÐµÐ½Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð²ÑÐ²Ð¾Ð´Ð° Ð² ÑÐµÐ¼Ð¾Ð½Ñ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ¾Ð² ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐµÐ¼Ñ Ð´Ð»Ñ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÑÑÑÐ¾Ð¹ÑÑÐ² ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸Ð¿Ð°.
ÐÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¾ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² ÑÐ»ÐµÐºÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ°ÐºÑÐ»ÑÑÐµÑÐ¾Ð² Ð²ÑÐ·Ð¾Ð².
Electrical manipulation of an electronic two-state system in Ge/Si quantum dots
Creators: name: Pryor, C. E.
name: Flatté, M. E.
name: Levy, J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We calculate that the electron states of strained self-assembled Ge/Si quantum dots provide a convenient two-state system for electrical control. An electronic state localized at the apex of the quantum dot is nearly degenerate with a state localized at the base of the quantum dot. Small electric fields shift the electronic ground state from apex-localized to base-localized, which permits sensitive tuning of the electronic, optical and magnetic properties of the dot. As one example, we describe how spin-spin coupling between two Ge/Si dots can be controlled very sensitively by shifting the individual dot's electronic ground state between apex and base.
The Role of Beauty as Currency Belief in Acceptance of Cosmetic Surgery and Career Aspiration among Chinese Young Women
Creators: name: Wang, Wenjing
name: Zheng, Xiaobing
name: Yue, Xiaodong
name: Zhong, Nian
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Arts and Humanities
subject: Social and Behavioral Sciences
subject: beauty
subject: self-objectification

description: Investigation of the “beauty as currency” hypothesis in the framework of Objectification theory with a sample of Chinese young women
title: ÐÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð°Ð²Ð°ÑÐ¸Ð¹Ð½ÑÑ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ð¹ ÑÐµÑ Ð½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾Ð±ÑÐµÐºÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ²Ð´Ð¾ÐºÐ¸Ð¼Ð¾Ð², ÐÐ¸ÑÐ°Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·
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ÑÑÐµÐ½Ð´Ð¾Ð²Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ
Ð°Ð²Ð°ÑÐ¸Ð¹Ð½ÑÐµ ÑÐ¸ÑÑÐ°ÑÐ¸Ð¸

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÑÐµÐ½Ð´Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð½ÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½ÑÑ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð² ÑÐ¾Ð·Ð´Ð°Ð½ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð°Ð²Ð°ÑÐ¸Ð¹Ð½ÑÑ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ð¹ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾Ð±ÑÐµÐºÑÐ°. Ð¡Ð¾Ð·Ð´Ð°Ð½Ð° ÐµÐ³Ð¾ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÑÑ Ð¼Ð¾Ð´ÐµÐ»Ñ, Ð²ÑÑÐ²Ð»ÐµÐ½Ñ ÑÑÐµÐ½Ð´Ñ, ÑÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð· Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¸ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð° Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð°Ð²Ð°ÑÐ¸Ð¹Ð½ÑÐµ ÑÐ¸ÑÑÐ°ÑÐ¸Ð¸. Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¸Ð¼ÐµÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÑÑÑ Ð²Ð¸Ð±ÑÐ¾Ð¼Ð¾Ð½Ð¸ÑÐ¾ÑÐ¸Ð½Ð³ Ð³Ð¸Ð´ÑÐ¾Ð°Ð³ÑÐµÐ³Ð°ÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð´Ð°Ð½Ð½ÑÑ Ñ 8 Ð´Ð°ÑÑÐ¸ÐºÐ¾Ð².
Dopamine receptor expression in rabbit corpora lutea
Creators: name: Mignini, Fiorenzo
name: Parillo, Francesco
name: Zerani, Massimo
name: Boiti, Cristiano
name: Cavallotti, Carlo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Fundamental Structures of M(brane) Theory
Creators: name: Hoppe, Jens
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A dynamical symmetry, as well as special diffeomorphism algebras generalizing the Witt-Virasoro algebra, related to Poincaré-invariance and crucial with regard to quantisation, questions of integrability, and M(atrix) theory, are found to exist in the theory of relativistic extended objects of any dimension.
Human papillomavirus type distribution and correlation with cyto-histological patterns in women from Benin
Creators: name: Piras, Franca
name: Piga, Michela
name: De Montis, Antonella
name: Atzori, Manuela
name: Pittau, Marco
name: Murtas, Daniela
name: Minerba, Luigi
name: Maxia, Cristina
name: Perra, Maria Teresa
name: Sirigu, Paola
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Human papilloma virus; cervical lesions

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
title: ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð¾-ÑÐ¾ÑÐ³Ð¾Ð²Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÑÐµÑÑÐ¾ÑÐ°Ð½Ð° Ñ ÐµÐ²ÑÐ¾Ð¿ÐµÐ¹ÑÐºÐ¾Ð¹ ÐºÑÑ Ð½ÐµÐ¹ Ð½Ð° 70 Ð¼ÐµÑÑ Ð² Ð¦ÐµÐ½ÑÑÐ°Ð»ÑÐ½Ð¾Ð¼ ÑÐ°Ð¹Ð¾Ð½Ðµ Ð³. Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð°
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾ÑÐ¸ÑÐµÐ½ÐºÐ¾, ÐÐ°Ð²ÐµÐ»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ðµ Ð¾Ð±ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ
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description: ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¾ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Â«ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð¾-ÑÐ¾ÑÐ³Ð¾Ð²Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÑÐµÑÑÐ¾ÑÐ°Ð½Ð° ÐµÐ²ÑÐ¾Ð¿ÐµÐ¹ÑÐºÐ¾Ð¹ ÐºÑÑÐ½Ð¸ Ð½Ð° 70 Ð¼ÐµÑÑ Ð² Ð¦ÐµÐ½ÑÑÐ°Ð»ÑÐ½Ð¾Ð¼ ÑÐ°Ð¹Ð¾Ð½Ðµ, Ð³. Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð°Â», Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ°ÑÑÐµÑÑ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÑÑÑÐºÑÑÑÐ° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, ÐµÐ³Ð¾ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð¾ÑÐ½Ð¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸.
Biological markers in CSF of Sardinian patients with multiple sclerosis
Creators: name: Tolu, Paola
name: Asara, Yolande
name: Delogu, Giuseppe
name: Sotgiu, Alessandra
name: Prados, Josè Carlos
name: Montella, Andrea
name: Madeddu, Roberto
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Multiple sclerosis; Sardinia; biomarkers; cerebrospinal fluid

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Octave Spanning Frequency Comb on a Chip
Creators: name: Del'Haye, P.
name: Herr, T.
name: Gavartin, E.
name: Holzwarth, R.
name: Kippenberg, T. J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Optical frequency combs have revolutionized the field of frequency metrology within the last decade and have become enabling tools for atomic clocks, gas sensing and astrophysical spectrometer calibration. The rapidly increasing number of applications has heightened interest in more compact comb generators. Optical microresonator based comb generators bear promise in this regard. Critical to their future use as 'frequency markers', is however the absolute frequency stabilization of the optical comb spectrum. A powerful technique for this stabilization is self-referencing, which requires a spectrum that spans a full octave, i.e. a factor of two in frequency. In the case of mode locked lasers, overcoming the limited bandwidth has become possible only with the advent of photonic crystal fibres for supercontinuum generation. Here, we report for the first time the generation of an octave-spanning frequency comb directly from a toroidal microresonator on a silicon chip. The comb spectrum covers the wavelength range from 990 nm to 2170 nm and is retrieved from a continuous wave laser interacting with the modes of an ultra high Q microresonator, without relying on external broadening. Full tunability of the generated frequency comb over a bandwidth exceeding an entire free spectral range is demonstrated. This allows positioning of a frequency comb mode to any desired frequency within the comb bandwidth. The ability to derive octave spanning spectra from microresonator comb generators represents a key step towards achieving a radio-frequency to optical link on a chip, which could unify the fields of metrology with micro- and nano-photonics and enable entirely new devices that bring frequency metrology into a chip scale setting for compact applications such as space based optical clocks.
Algorithmic Solutions to Some Transportation Optimization Problems with Applications in the Metallurgical Industry
Creators: name: Andreica, Mugurel Ionut
name: Briciu, Sorin
name: Andreica, Madalina Ecaterina
Publisher: name: arXiv
Year: 2009
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Computational Geometry (cs.CG)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences
subject: G.2.2; G.2.1

description: In this paper we address several constrained transportation optimization problems (e.g. vehicle routing, shortest Hamiltonian path), for which we present novel algorithmic solutions and extensions, considering several optimization objectives, like minimizing costs and resource usage. All the considered problems are motivated by practical situations arising, for instance, in the mining and metallurgical industry or in data communication. We restrict our attention to transportation networks with path, tree or geometric structures, for which the developed polynomial-time algorithms are optimal or nearly optimal.
Assessing the University of Alberta Humanities and Social Sciences Library Japanese Library Collection and Preparing a Plan for its Development
Creators: name: Gonnami, Tsuneharu, 1940-
Publisher: name: The University of British Columbia
Year: 2010

description: Note: T. Gonnami, Japanese Librarian of the University of British Columbia, was invited by the University of Alberta to conduct an evaluation of their Japanese collection on April 18-22, 1994.
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð°ÑÑÐ¾ÑÑÐ¸Ð¼ÐµÐ½ÑÐ° Ð¸ ÑÐºÑÐ¿ÐµÑÑÐ¸Ð·Ð° ÐºÐ°ÑÐµÑÑÐ²Ð° ÑÐ¿Ð¾ÑÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¾Ð±ÑÐ²Ð¸
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð»Ð¸ÑÐµÐ², ÐÐµÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾ Ð¾Ð±ÑÐ²Ð¸
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Morpho-functional evaluation of the activity of stereoisomers of the antioxidant alpha-lipoic (tioctic) acid in a model of compressive neuropathy
Creators: name: Tomassoni, Daniele
name: Di Cesare Mannelli, Lorenzo
name: Pacini, Alessandra
name: Bonaccini, Laura
name: Ghelardini, Carla
name: Traini, Enea
name: Amenta, Francesco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Peripheral nerve; chronic constriction injury; neurorestoration; morphology; oxidative stress

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells
Creators: name: Wu, Hai-Bo
name: Yang, Shuai
name: Weng, Hai-Yan
name: Chen, Qian
name: Zhao, Xi-Long
name: Fu, Wen-Juan
name: Niu, Qin
name: Ping, Yi-Fang
name: Ming Wang, Ji
name: Zhang, Xia
name: Yao, Xiao-Hong
name: Bian, Xiu-Wu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Antiangiogenesis with bevacizumab, an antibody against vascular endothelial growth factor (VEGF), has been used for devascularization to limit the growth of malignant glioma. However, the benefits are transient due to elusive mechanisms underlying resistance to the antiangiogenic therapy. Glioma stem cells (GSCs) are capable of forming vasculogenic mimicry (VM), an alternative microvascular circulation independent of VEGF-driven angiogenesis. Herein, we report that the formation of VM was promoted by bevacizumab-induced macroautophagy/autophagy in GSCs, which was associated with tumor resistance to antiangiogenic therapy. We established a 3-dimensional collagen scaffold to examine the formation of VM and autophagy by GSCs, and found that rapamycin increased the number of VM and enhanced KDR/VEGFR-2 phosphorylation. Treatment with chloroquine, or knockdown of the autophagy gene ATG5, inhibited the formation of VM and KDR phosphorylation in GSCs. Notably, neutralization of GSCs-produced VEGF with bevacizumab failed to recapitulate the effect of chloroquine treatment and ATG5 knockdown, suggesting that autophagy-promoted formation of VM was independent of tumor cell-derived VEGF. ROS was elevated when autophagy was induced in GSCs and activated KDR phosphorylation through the phosphoinositide 3-kinase (PI3K)-AKT pathway. A ROS inhibitor, N-acetylcysteine, abolished KDR phosphorylation and the formation of VM by GSCs. By examination of the specimens from 95 patients with glioblastoma, we found that ATG5 and p-KDR expression was strongly associated with the density of VM in tumors and poor clinical outcome. Our results thus demonstrate a crucial role of autophagy in the formation of VM by GSCs, which may serve as a therapeutic target in drug-resistant glioma.