cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Convenient approach to chiral 4-monosubstituted 1,3-oxazolidine-2-thiones
Creators: name: Lu, Zheng
name: Yang, Yong-Qing
name: Jiu-Hui Li
name: Jun-Nan Wei
name: Yi-Zhu Wang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Chiral 4-monosubstituted 1,3-oxazolidine-2-thiones are regarded as one of the modified version of Evans auxiliaries in asymmetric aldol condensation, which can generate two adjacent chiral carbon centers in one time They have advantages over Evans auxiliaries in some aspects, however, their application is highly limited by their preparation approaches as toxic or flammable chemicals are involved. Here, a mild and applicable procedure for preparing the chiral oxazolidine-2-thione auxiliaries has been developed in this article. Potassium ethylxanthate and the corresponding chiral amino alcohols as the starting material in absolute ethanol are mixed and the mixture are heated under reflux for 1 h in open air to provide 1,3-oxazolidine-2-thiones chiral auxiliaries in moderate to excellent yields.
Additional file 3 of Performance of BioFire array or QuickVue influenza A + B test versus a validation qPCR assay for detection of influenza A during a volunteer A/California/2009/H1N1 challenge study
Creators: name: McIlwain, David R.
name: Chen, Han
name: Apkarian, Maria
name: Affrime, Melton
name: Bock, Bonnie
name: Kim, Kenneth
name: Mukherjee, Nilanjan
name: Nolan, Garry P.
name: McNeal, Monica M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 3: Figure S1. Confirmatory PCR product from positive virus control. An expected single band of ~177bp amplified by PCR demonstrates the specificity of the primers to amplify the targeted region of the HA gene.
Σύνθεση και χαρακτηρισμός καινοτόμων προσροφητικών υλικών με απόθεση οξειδίου του Mg, La και Si σε ενεργό άνθρακα για την απομάκρυνση οξυανιόντων από το πόσιμο νερό
Creators: name: Τρικαλιώτη, Σουλτάνα Δημητρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Προσρόφηση
Ενεργός άνθρακας
Πόσιμο νερό
Adsorption
Activated carbon
Drinking water

description: Σκοπός της διπλωματικής εργασίας ήταν η μελέτη καινοτόμων προσροφητικών υλικών για την απομάκρυνση φθορίου και χρωμίου με τη μορφή οξυανιόντων ή ανιόντων από υδάτινα υποστρώματα μέσω της διεργασίας της προσρόφησης. Για την σύνθεση των προσροφητικών υλικών, χρησιμοποιήθηκε ενεργός άνθρακας ο οποίος υπέστη τροποποίηση με στόχο την βελτιστοποίηση των ιδιοτήτων των υλικών, την αύξηση της προσροφητικής τους ικανότητας και επομένως την απομάκρυνση φθορίου και χρωμίου στις βέλτιστες αποδόσεις. Η χημική τροποποίηση του ενεργού άνθρακα πραγματοποιήθηκε με την εναπόθεση μαγγανίου, λανθανίου, πυριτίου. Στη συνέχεια, τα καινοτόμα προσροφητικά υλικά εφαρμόστηκαν και μελετήθηκαν ως προς την ικανότητα και την αποτελεσματικότητα απομάκρυνσης χρωμίου και φθορίου, μέσω της διεργασίας της προσρόφησης. Επιπλέον πραγματοποιήθηκαν πειράματα μελέτης και βελτιστοποίησης των παραμέτρων που επιδρούν στην αποτελεσματικότητά τους, όπως επίσης και αποτίμησης της ικανότητας επαναχρησιμοποίησης των υλικών σε περισσότερους από έναν κύκλους προσρόφησης.
description: The aim of the diploma thesis was the investigation of innovative adsorbent materials for the adsorption-based removal of fluorine anions and chromium oxyanions from aqueous solutions. Activated carbon, serving as the fundamental material for synthesizing the adsorbents, was modified aiming to enhance the adsorption properties of the adsorbents, increase their adsorption capacity and ultimately achieve the maximum removal efficiency of the absorbates. The activated carbon was modified with Mg, La and Si oxide deposition. Subsequently, the effectiveness and removal efficiency of these innovative adsorbent materials were examined. Additionally, a series of experiments were conducted to optimize various competitive adsorption parameters that influence the adsorption performance and to evaluate the regeneration efficiency of the materials.
CCWI2017: F122 'Comparison between Optimal and Real Design in Water Distribution Systems (WDS). Effect of Population Growth during the Project Lifespan.'
Creators: name: Posada, Alejandra
name: Bohórquez, Jessica
name: Robles, Juliana
name: Saldarriaga, Juan
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Urban processes affect Water Distribution Systems (WDS) and cause unsatisfactory operation, which violates the minimum pressure limit. For this reason, stablishing a valid rehabilitation criteria based on previous studies is necessary. In this paper a methodology to verify the results obtained by Specific Power and Resilience Index criteria is presented. The results obtained for six study cases in Colombia were analyzed in terms of costs, parameters and number of changes showing a reduction in costs and a reduced number of changes in the algorithm based on the second index.
Η συμβολή του Αγίου Νικοδήμου στη μετάφραση των αγιολογικών πηγών. Η περίπτωση του Νέου Εκλογίου
Creators: name: Σταύρου-Τσάγκα, Ελευθερία Βασιλείου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Άγιος Νικόδημος
Όσιος Νήφων ο Αθωνίτης
Νέο Εκλόγιο
Saint Nicodemus
Saint Nifon Athonites
Neon Eklogion

description: Η εκπόνηση της διπλωματικής μου εργασίας με θέμα: “Η συμβολή του Αγίου Νικοδήμου του Αγιορείτη στην μετάφραση των αγιολογικών πηγών. Η περίπτωση του Νέου Εκλογίου”, έχει ως σκοπό να συμβάλει στην μελέτη του βίου και του έργου του Αγίου Νικοδήμου του Αγιορείτου μέσα από την γλωσσική και υφολογική σύγκριση των δυο αντιπαρατιθέμενων κειμένων, την απόδοση του βίου του Οσίου Νήφωνα του Αθωνίτη από τον Halkin από την μία, και την απόδοση του βίου του στο Νέο Εκλόγιο, από την άλλη. Από όσα παρουσιάζονται στην εργασία σχετικά με τις ιδιομορφίες που παρουσιάζει η γλώσσα και το ύφος του κειμένου του βίου στο Νέον Εκλόγιον, συνεπάγεται ότι το έργο ανήκει στη δημώδη ελληνική της εποχής ενώ παράλληλα διατηρεί στοιχεία της λόγιας γλώσσας. Η υφολογική παρουσίαση καταδυκνεύει ότι πρόκειται για ένα κείμενο το οποίο είναι απλό και κατανοητό στους αναγνώστες, με έμφαση στην ενίσχυση του θρησκευτικού αισθήματος. Ακολούθως, η δομή του κειμένου είναι η συγκροτημένη ώστε εύκολα οι αναγνώστες να μπορούν να αποτυπώσουν το κεντρικό νόημα των παραγράφων. Παρατηρούμε παράλληλα, την τάση του συγγραφέα να αποφύγει την υπερβολή της παράθεσης των θαυμάτων του Οσίου Νήφωνος, διακόπτοντας τη γραμμική αφήγησή τους μέσα στον πραγματικό χρόνο τέλεσής τους, και επαναφέροντας τα στο τέλος του βίου.
description: The preparation of my diploma thesis on the topic: "The contribution of Saint Nicodemus to the translation of the holy sources. The case of Neon Eklogion", aims to contribute to the study of the life and work of Saint Nicodemus through the linguistic and stylistic comparison of the two juxtaposed texts, the rendering of the life of Saint Nifon Athonites by Halkin from one, and the performance of his life in Neon Eklogion, on the other. From what is presented in the paper regarding the peculiarities presented by the language and the style of the text of the life in Neon Eklogion, it follows that the work belongs to the vernacular Greek of the time while at the same time preserving elements of the spoken language. The stylistic presentation reveals that it is a text that is simple and understandable to the readers, with an emphasis on strengthening the religious feeling. Next, the structure of the text is structured so that readers can easily capture the central meaning of the paragraphs. At the same time, we observe the author's tendency to avoid the exaggeration of quoting the miracles of Saint Nifon, interrupting their linear narrative during the actual time of their performance, and bringing them back at the end of life.
Design of flexible smart robotic instruments for minimally invasive surgery
Creators: name: Seneci, Carlo Alberto
Publisher: name: Imperial College London
Year: 2016

description: Robots made their debut in the surgical field about 20 years ago in an attempt to introduce improvements in laparoscopy. With evolving technology, these robots became well appreciated for their stable performance, tremor cancelling and increased dexterity. On the other hand, at present, there is no strong clinical evidence that suggests that robotic surgery is preferable to laparoscopy. This is due to the fact that this discipline is still relatively young; therefore some challenges in traditional laparoscopic surgery still have to be addressed with an enhanced robot. Only a holistic approach to the design of surgical instruments will allow the next generation of surgical robots to realise their full potential and allow for a wider clinical uptake. This thesis focuses on the design and manufacture of a smart robotic surgical instrument, that addresses the main challenges posed by Transanal Endoscopic Microsurgery (TEM). The need for dexterity and triangulation is satisfied with the design of highly articulated end-effectors, while the instrument diameter is designed to be comparable to those of laparoscopic instruments. Furthermore, a viable manufacturing process was studied and proposed the production of components that would be difficult to produce with different manufacturing techniques. In order to reduce the amount of instrument interchanges that normally occur during surgery, one of the strategies followed during the design phase aimed to provide the instruments with some degree of multifunctionality. This also had the further benefit of allowing smoke evacuation that is a limiting factor in many small-lumen surgeries. Force sensing was also explored, proposing two different strategies. The first one uses a disposable sensor clip and the other proposes the design of a robotic coupling interface, which embeds force sensing into the couplings between the robot actuation and the robotic instrument. Furthermore, rigorous bench testing, user trials, in-vivo and ex-vivo studies have been carried out to validate the proposed surgical robot in different scenarios. The proposed surgical robot demonstrated great potential for its use in clinical practice, achieving suitable performance in all the tests performed. Bench tests demonstrated the robustness and repeatability of the performance, while user-based experiments showed its applicability and a quick learning curve. On the other hand, the design was based on the idea of producing a disposable instrument. Therefore, future work will address the possibility of using the instruments multiple times with re-sterilisation through autoclave.
DO'STLIK HAQIDAGI G'OYALAR BUYUK AJDODLARIMIZ NIGOHIDA
Creators: name: Axmedov, K.M.
name: Sherbutayeva, G.K.
Publisher: name: Zenodo
Year: 2025

description: Insoniyat tаrаqqiyotidа  shundаy tushunchаlаr mavjudki hech qachon  o’z   ma'nosini yo'qotmaydi.   Bu do'stlik tushunchasi. Asrlar davomida u insoniyat jаmiyatining enг muhim ko'rsatkichi sifatida o'rganilаdi. Do'stlik haqida ko'plab fikrlar bildirilgan va oltin so'zlar ifodalangan. Ulardа barcha xalqlar va millatlarning buyuk  mа’nаviy boyliklari ifoda etilgаn. Ushbu maqolada biz buyuk ajdodimiz Ibn Sinoning do'stlik haqidagi ba'zi fikrlarini keltirdik, unda mutafakkirning do'stlik va do'stlarni tanlash haqidagi ajoyib fikrlari bayon etilgan.
CCWi2017: F35 'FRACTALITY IN WATER DISTRIBUTION NETWORKS'
Creators: name: Kegong Diao
name: Butler, David
name: Ulanicki, Bogumil
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Fractals have been identified as a common feature of many natural and artificial systems that exhibit similar patterning at different scales. Understanding fractals is a critical aspect of decoding complex systems, as the pattern of such large systems can be revealed by identifying only a small part of the system. Furthermore, identify existing features of such systems can start at the large scale with the fewest details of the system under scrutiny before doing a more detailed analysis at finer scales. Such a process provides an efficient and reliable way of analysing and managing information of big data systems. This study revealed the fractality in water distribution networks (WDNs) based on research on fractals in complex networks. Specifically, we explored the existence of fractal patterns in six real world WDNs of different complexities (e.g. from a network with only 21 pipes to a network with 2465 pipes). The box-covering algorithm has been applied, which is the most widely used method to distinguish between fractal or non-fractal networks. The WDNs are first mapped into undirected graphs. Next, the method partitions the nodes into boxes of size l B , i.e. the maximal distance between nodes within each box is at most l B − 1 . By varying the box sizes, different minimum numbers of boxes N B required to cover the entire network can be identified. A network is fractal if the regression line for log ( N B ) and log ( l B ) is linear. The results demonstrate the existence of fractal patterns in all case study WDNs, as linear regression lines with coefficient of determination over 0.95 ( R 2 > 0 . 95 ) are obtained in all analyses. As further verification, the self-similarity on multiscales is revealed, i.e. the similarity in patterns of component criticality. Based on the fractal patterns, a systematic method is also developed for more efficient identification of critical pipes in WDNs, e.g. reducing the computational load by 61% in the case study.
The application of process mining to care pathway analysis in the NHS
Creators: name: Siddiqi, Bushra
Publisher: name: Imperial College London
Year: 2017

description: Background: Prostate cancer is the most common cancer in men in the UK and the sixth-fastest increasing cancer in males. Within England survival rates are improving, however, these are comparatively poorer than other countries. Currently, information available on outcomes of care is scant and there is an urgent need for techniques to improve healthcare systems and processes. Aims: To provide prostate cancer pathway analysis, by applying concepts of process mining and visualisation and comparing the performance metrics against the standard pathway laid out by national guidelines. Methods: A systematic review was conducted to see how process mining has been used in healthcare. Appropriate datasets for prostate cancer were identified within Imperial College Healthcare NHS Trust London. A process model was constructed by linking and transforming cohort data from six distinct database sources. The cohort dataset was filtered to include patients who had a PSA from 2010-2015, and validated by comparing the medical patient records against a Case-note audit. Process mining techniques were applied to the data to analyse performance and conformance of the prostate cancer pathway metrics to national guideline metrics. These techniques were evaluated with stakeholders to ascertain its impact on user experience. Results: Case note audit revealed 90% match against patients found in medical records. Application of process mining techniques showed massive heterogeneity as compared to the homogenous path laid out by national guidelines. This also gave insight into bottlenecks and deviations in the pathway. Evaluation with stakeholders showed that the visualisation and technology was well accepted, high quality and recommended to be used in healthcare decision making. Conclusion: Process mining is a promising technique used to give insight into complex and flexible healthcare processes. It can map the patient journey at a local level and audit it against explicit standards of good clinical practice, which will enable us to intervene at the individual and system level to improve care.
Aldehyde metabolic reprogramming in oesophageal adenocarcinoma
Creators: name: Antonowicz, Stefan
Publisher: name: Imperial College London
Year: 2017

description: Oesophageal adenocarcinoma (OAC) has unmet clinical needs as the UK five-year survival is 14%. Efforts to enhance early diagnosis uncovered enriched volatile aldehydes in OAC patients’ breath, although their origins and fate are unknown. Following comprehensive bioinformatics analyses, it was hypothesised that detoxification loss enriches aldehydes in the transforming lower oesophagus. Pursuing this biology could help refine OAC breath testing, deepen understanding of oncogenesis and uncover therapeutic susceptibilities. This PhD aimed to describe OAC aldehyde metabolism, its genetic framework, and its oncogenic effects. A bespoke ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was validated to unambiguously quantify 43 aldehydes and ketones in tissue samples. Multiple aldehyde species were enriched in OAC tissues, suggesting active carbonyl stress, field effects, and a requirement for competent defences. Genetically, aldehyde oxidoreductase expression loss defined OAC tissues, compared to normally resident tissue. Five aldehyde dehydrogenase isoenzymes were consistently and significantly depleted (P < 10-8 to -20); these findings were validated at the RNA (n = 67) and protein (n = 412) levels in clinical samples. In particular, loss of ALDH3A2 was associated with disease progression and independently predicted poorer survival (OR = 1.64, 95% C.I. 1.13 – 2.39, P = 0.01). To explore the effects of aldehyde metabolic rewiring, a second UPLC-MS/MS method was developed, which suggested that aldehyde-DNA adducts are also enriched in OAC tissues. Mechanistic studies in vitro revealed that ALDH inhibition is sufficient to enrich metabolic aldehyde in OAC cells. Finally, stable perturbation of ALDH3A2 in OAC cells highlighted a potential tumour suppressor role for this gene, as CRISPR-Cas9 mediated knockout enhanced cell growth through cell cycle shunting and affected redox control. These data highlight genetically deregulated aldehyde metabolism as a feature of OAC, which may contribute to carcinogenesis. Clinical implications and future research directions are discussed.
Additional file 1 of Comprehensive analysis of tumour mutational burden and its clinical significance in prostate cancer
Creators: name: Wang, Lijuan
name: Pan, Shucheng
name: Zhu, Binbin
name: Yu, Zhenliang
name: Wang, Wei
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Table S1. Setting items of the transcriptome data. Table S2. Setting items of the clinical data. Table S3. Setting items of the mutation data.
Epigenomic profiling of oestrogen receptor-positive breast cancer
Creators: name: Patten, Darren
Publisher: name: Imperial College London
Year: 2017

description: Endocrine resistance occurs in the majority of patients who have relapsing breast cancer which remains a challenge to current medical treatment. Tumour heterogeneity poses an obstacle in clinical diagnostics which can lead to suboptimal treatment and the development of therapy resistance. Although tumour heterogeneity, at an intrinsic as well as at an interpatient level, is a potential contributor to endocrine resistance in oestrogen receptor-positive breast cancer, it is not clearly understood. Epigenetically-defined regulatory regions including promoters and enhancers govern cell type specific transcription. In this study, I have processed 47 fresh-frozen primary and metastatic oestrogren receptor-positive breast cancer samples for H3K27ac (acetylation of lysine 27 on histone 3) chromatin immunoprecipitation and high throughput sequencing. The regulatory landscapes of the 47 patient samples were analysed and key regulatory drivers identified. Results demonstrate that although enhancer elements are strongly associated with epigenetic heterogeneity, dominant enhancers tend to be shared across patients. Identified regulatory drivers possess binding sites for the transcription factor YY1 which collaborates with the oestrogen receptor alpha to drive the transcription of several key genes including SLC9A3R1. SLC9A3R1 has subsequently been identified as a novel breast cancer specific oncogene and is shown in this study to stratify oestrogen receptor-positive breast cancer patients. This study demonstrates for the first time that epigenetic annotations can be used to map regulatory, as well as phenotypic, changes through breast cancer progression.
Annotations on letter B moving from Petrucci’s article
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 4
description: Observations on A. PETRUCCI, Per la storia della scrittura romana: i graffiti di Condatomagos, "Bullettino dell'archivio paleografico italiano", III serie , 1 (1962), 85-132.
description: Source: 4MAR_1_1.3.1-3-1
description: created: n. d.
CCWI2017: F108 'Comparison of Different Controllers for Equitable Water Supply in Water Networks'
Creators: name: G R Anjana
name: M S Mohan Kumar
name: Bharadwaj Amrutur
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Equitable distribution of water among consumers is one of the most important agenda for many water authorities around the world. Many methods have been listed in literature for equitable distribution of water. In recent years, different automatic controller based approaches were also introduced for flow control in water systems. In this work, a comparative study is carried out among Dynamic Inversion based PID (DI-PID), Model Predictive Control (MPC) and EnKF based PID controllers for flow control application in real time for a water distribution network- Bangalore inflow water distribution system. It was observed that the DI-PID and EnKF based PID controllers are better than other controllers for equitable distribution of water in a mega city like Bangalore.
Additional file 7: of Genome-wide identification and characterization of long non-coding RNAs involved in the early somatic embryogenesis in Dimocarpus longan Lour
Creators: name: Chen, Yan
name: Li, Xue
name: Su, Liyao
name: Chen, Xu
name: Zhang, Shuting
name: Xu, Xiaoping
name: Zhang, Zihao
name: Chen, Yukun
name: XuHan, Xu
name: Lin, Yuling
name: Lai, Zhongxiong
Publisher: name: figshare
Year: 2018
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: qPCR validation of five miRNAs involved in â auxin responseâ regulation of lncRNAs. Dlo-miR172a was used as a reference gene to normalize miRNA expression data; FSD was used to normalize lncRNAs and mRNAs. (PDF 406 kb)
Assessing the coordinated revenue-sharing contract of China’s farmer-supermarket direct-purchase model
Creators: name: Liang, Pen
name: Sima, Melat
name: Huang, Yu
name: Sun, Xiaoyu
name: Liang, Pen
name: Sima, Melat
name: Huang, Yu
name: Sun, Xiaoyu
Publisher: name: Unknown
Year: 2022
Subjects: subject: Demand and Price Analysis
subject: Marketing
subject: FOS: Economics and business
subject: farmer-supermarket direct-purchase
subject: perishable agricultural product
subject: revenue-sharing contract
subject: supply chain coordination

description: China began connecting farmers directly with supermarkets 10 years ago, when they were at a disadvantage and forced to sell products at low prices, as unstable cooperation among supply chain participants led to inequitable distribution of revenue. Revenue-sharing contracts offer a risk-sharing approach to ensure supply chain coordination and optimize profit for all. Research on short life cycle products with revenue-sharing contracts assume stable prices or investigate the effects of revenue-sharing contracts on supply chain coordination. This study introduced a revenue-sharing contract model into a ‘farmer-supermarket direct-purchase’ supply chain, considering price fluctuation and retail promotional efforts, stochastic market demand, among other factors. Revenue-sharing contracts achieved long-term stability in supply chain coordination, all participants obtained more profits, and the size of revenue-sharing parameter depends on the position and bargaining power of all participants. A case study on Tianhong supermarket and Nanxia farmer cooperative verified these findings, eliciting practical implications for professionals and policymakers.
CCWI2017: F36 'Segments Identification in Water Distribution Systems by Using Network Topological Matrices'
Creators: name: Mahmoud, Herman
name: Kapelan, Zoran
name: Savic, Dragan
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The partitioning of water distribution systems (WDS) into segments and district metered areas (DMAs) provides various management benefits for system operators [1,2]. These benefits include, for instance, improved pressure management, more efficient leakage control and effective isolation of network parts in cases of pipe breakages or equipment failures. All this, in turn, increases system reliability and resilience [3]. Identification of network segments depends mainly on the distribution and location of valves in a given WDS. In general, valves are used for controlling flow conditions (i.e., pressure and flow) and for isolating a failure area due to pipe breakage/equipment failure or contamination events. In this paper, a methodology is proposed to identify network segments (i.e., sets of pipes and nodes) that belong to an individual valve or a set of valves. The methodology is developed based on the basic network topological matrices (i.e., node-link connectivity matrix, valves topological matrix) [2]. In comparison to other existing methods, the proposed methodology has able to produce all segments for a given WDS in single network run without introducing pseudo valves, pipes and auxiliary valve matrix [2,3,4] or performing hydraulic analysis. Additionally, it is very simple for computer coding and does not require the user to have extensive programming knowledge. Figure 1 shows the steps for the methodology and segmentation results obtained on a simple network under a hypothetical pipe failure scenario (i.e., burst pipe p2). The methodology has been further validated and demonstrated on the well-known C- Town network [5]. The results show that the approach is capable of identifying both regular segment valves association and unintentionally isolated segments [4] in an accurate and efficient way. A regular segment is a part of the network (i.e., nodes and pipes) that contains the failure element to be isolated from the rest of the network (e.g., pipe failure), which needs to be repaired or fully replaced. While an unintentionally isolated segment is the portion of the network that is separated from water source(s) as a consequence of isolating a regular segment (as shown in Figure 1). Due to its generic nature and relative simplicity, the proposed methodology has the ability to create network segments in an automated way from network input data, e.g., by reading and automatically processing the relevant data from the EPANET2.0 input file. The methodology proposed, therefore, lends itself naturally to tackling practical problems, such as determining strategic and optimal location for isolation and PRV valves, WDS reliability, and response approaches to network failure events
p53 is a hub for the integration of multiple vascular quiescence signals in the subventricular zone stem cell niche
Creators: name: Davies, Timothy
Publisher: name: Imperial College London
Year: 2017

description: Neurogenesis is the process by which new neurons are produced from neural stem cells (NSCs) in the brain. In the adult mammal, the subventricular zone (SVZ) and subgranular zone constitute the two neurogenic areas that continue to produce neurons over the life of the animal. SVZ NSCs (type b cells) reside in a niche which provides them with a host of signals that co-ordinate their behaviour. Type b cells are maintained in a quiescent, non-dividing state, in part through contact dependent signals supplied by vascular endothelial cells. I performed a mass spectroscopy screen to identify factors expressed by endothelial cells that enforce NSC quiescence, and showed that ephrin B2 and BMP4 are the main endothelial quiescence signals in vitro. To ascertain how these signals are transduced, I performed RNA sequencing of NSCs grown in co-culture with endothelial cells. This showed p53 as a key transducer of endothelial quiescence signals. Both ephrin B2 and BMP4 were found to be dependent on p53 for their quiescence activity. Interestingly, enquiry into signalling downstream of p53 showed that proliferative arrest is independent of its canonical effector p21. In contrast, p53 was found to regulate levels of EGFR, and BMP4 caused a reduction in EGFR which is abrogated upon loss of p53. Thus, p53 may control NSC quiescence at least in part through controlling levels of EGFR in response to endothelial BMP4. Despite indications that p53 is important for transducing endothelial quiescence signals in vitro, acute loss of p53 in type b cells in vivo had no effect on the number of proliferating type b cells. Finally, I describe work performed establishing super-resolution imaging techniques to enquire into morphological changes following type b cell activation. Thus, this thesis makes a contribution to our understanding of the regulation of neural stem cell quiescence by the SVZ vascular niche.
CCWI2017: F134 'An Improved Simulated Annealing Algorithm for Solving Complex Water Distribution Networks'
Creators: name: Cunha, Maria
name: Marques, João
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Optimising the design of water distribution networks (WDNs) is a well-known problem that has been studied by numerous researchers. This work proposes a heuristic based on simulated annealing and improved by using concepts from the cross-entropy method. The proposed optimization approach is presented and used in two case studies of different complexity. The results show not only a fall in the computational effort of the new approach relative to simulated annealing but also include a comparison with other heuristic results from the literature, used to solve the same problems.
Additional file 1 of Outcomes of bicanalicular nasal stent inserted by sheath-guided dacryoendoscope in patients with lacrimal passage obstruction: a retrospective observational study
Creators: name: Kamao, Tomoyuki
name: Zheng, Xiaodong
name: Shiraishi, Atsushi
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. The GBI questionnaire. Total Score: Sum all the responses (Qu. 1–18). Divide by 18 (to obtain an average response score). Subtract 3 from the average response score. Multiply by 50. General Subscale Score: Sum 12 of the responses (Qu. 1,2,3,4,5,6,9,10,14,16,17 and 18). Divide by 12 (to obtain an average response score). Subtract 3 from the average response score. Multiply by 50. Social Support Score: Sum 3 of the responses (Qu. 7,11,15). Divide by 3(to obtain an average response score). Subtract 3 from the average response score. Multiply by 50. Physical Health Score: Sum 3 of the responses (Qu. 8,12,13). Divide by 3(to obtain an average response score). Subtract 3 from the average response score. Multiply by 50.
Investigation of dysfunctional aromatic amino acid metabolism in oesophago-gastric cancer and link to phenol production
Creators: name: Wiggins, Thomas Henry
Publisher: name: Imperial College London
Year: 2017

description: Oesophago-gastric cancer is a significant health problem in the United Kingdom. Only 37.6% of patients can be treated with curative intent at the time of diagnosis. The development of non-invasive biomarkers aims to identify patients at early stages of the condition prior to disease spread. Phenol has been proposed as a potential marker of oesophago-gastric cancer in exhaled breath and urine. The nature of origin of this compound is unknown. The aim of this research was to investigate the link between aromatic amino acid metabolism and phenol production in oesophago-gastric cancer; the long term aim being to validate the use of phenol as a non-invasive marker of this disease. Dried blood spot samples were analysed using nano-electrospray ionisation mass spectrometry to identify intermediary metabolites of aromatic amino acid metabolism. Homogentisate was identified at reduced concentrations in oesophago-gastric cancer patients. These results led to a targeted investigation of enzymes regulating this pathway using quantitative PCR and immunohistochemistry. Homogentisate 1,2 dioxygenase was found to be downregulated in oesophageal cancer tissues. To investigate phenol production gastric content samples were analysed using gas-chromatography mass spectrometry. Phenol was consistently identified within gastric content samples, and addition of isotope labelled tyrosine indicated that phenol was produced from this aromatic amino acid in gastric juice. Bacterial sequencing identified the presence of phenol producing bacteria within the stomach. Phenol concentrations were significantly increased in the plasma of these patients, providing a transport mechanism for phenol produced in the tumour environment to be excreted by the lungs or kidneys. Urinary analysis also revealed increased concentrations of phenol relative to controls. This work has indicated that the gastric microbiome may be responsible for conversion of tyrosine to phenol in oesophago-gastric cancer. The underlying mechanism responsible for aromatic amino acid dysfunction has also been identified. By demonstrating the biological mechanism responsible for phenol production this project has validated the use of this compound as a non-invasive marker of this disease in exhaled breath or urine. These findings will help to introduce the clinical use of phenol as a non-invasive marker for oesophago-gastric cancer risk stratification, thereby increasing the proportion of patients diagnosed at early stages of disease and improving overall survival.
Topical chemotherapy for the treatment of melanocytic conjunctival tumors
Creators: name: Τζώρτζη, Παναγιώτα Λεωνίδα
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Μελάνωμα επιπεφυκότα
Πρωτοπαθής επίκτητη μελάνωση
Τοπική, ιντερφερόνη, μιτομυκίνη
Conjunctival melanoma
Primary acquired melanosis
Topical, interferon, mitomycin C

description: Conjunctival Melanoma (CM) is a pigmented laceration on the exterior of the eye and a malignant tumor that affects the outer eye tissues, including the bulbar and palpebral conjunctiva or the caruncle. It is a rare but potentially devastating tumor capable of invading local eye tissues, spreading through lymphatic or blood circulation, and recurring despite treatment. Primary Acquired Melanosis (PAM) is an acquired pigmentation of the conjunctiva that can develop into CM. The preferred treatment for these malignancies is surgical excision. In cases of PAM with atypical melanocytes or CM, as well as in cases of relapsed or widespread disease, topical chemotherapy is used as a non-surgical approach to treat conjunctival tumors. This method involves delivering high concentrations of drugs to the ocular surface. The available literature predominantly comprises collections of cases with varying levels of quality, and there is a significant range of approaches in handling these situations. The purpose of this review is to critically evaluate the available literature, come up with an overview of the main research results concerning the application of topical chemotherapy and highlight the results after administering primary or adjuvant chemotherapy.
description: Το μελάνωμα του επιπεφυκότα είναι μια μελανοκυτταρική αλλοίωση στο εξωτερικό του ματιού και ένας κακοήθης όγκος που προσβάλλει τους εξωτερικούς ιστούς του ματιού, συμπεριλαμβανομένου του βολβικού και του βλεφαρικού επιπεφυκότα ή την μηνοειδή πτυχή. Είναι ένας σπάνιος αλλά δυνητικά θανατηφόρος όγκος ικανός να εισβάλλει στους τοπικούς ιστούς του ματιού, να εξαπλώνεται μέσω της λεμφικής ή της αιματικής κυκλοφορίας και να υποτροπιάζει παρά τη θεραπεία. Η πρωτοπαθής επίκτητη μελάγχρωση (ΠΕΜ) είναι μια επίκτητη μελάγχρωση του επιπεφυκότα που μπορεί να εξελιχθεί σε μελάνωμα. Η προτιμώμενη θεραπεία για αυτές τις κακοήθειες είναι η χειρουργική αφαίρεση. Σε περιπτώσεις ΠΕΜ με άτυπα μελανοκύτταρα ή μελανώματος, καθώς και σε περιπτώσεις υποτροπιάζουσας ή εκτεταμένης νόσου, η τοπική χημειοθεραπεία χρησιμοποιείται ως μη χειρουργική προσέγγιση για τη θεραπεία αυτών των όγκων. Η μέθοδος αυτή περιλαμβάνει τη χορήγηση υψηλών συγκεντρώσεων φαρμάκων στην οφθαλμική επιφάνεια. Η διαθέσιμη βιβλιογραφία περιλαμβάνει περιστατικά με διαφορετικά ποιοτικά χαρακτηριστικά και υπάρχει σημαντικό εύρος προσεγγίσεων στον χειρισμό αυτών των καταστάσεων. Σκοπός της παρούσας ανασκόπησης είναι να αξιολογήσει κριτικά τη διαθέσιμη βιβλιογραφία, να καταλήξει σε μια επισκόπηση των κυριότερων ερευνητικών αποτελεσμάτων σχετικά με την εφαρμογή τοπικής χημειοθεραπείας και να αναδείξει τα αποτελέσματα μετά τη χορήγηση πρωτογενούς ή επικουρικής χημειοθεραπείας.
Relational goods and direct purchase from farmers: estimating the value of the relationship between consumers and producers
Creators: name: Corsi, Alessandro
name: Frontuto, Vito
name: Novelli, Silvia
name: Corsi, Alessandro
name: Frontuto, Vito
name: Novelli, Silvia
Publisher: name: Unknown
Year: 2022
Subjects: subject: Institutional and Behavioral Economics
subject: Marketing
subject: FOS: Economics and business
subject: direct sales
subject: alternative food networks
subject: relational goods
subject: stated preferences

description: Personal relationships can affect economic life, more importantly in alternative food networks. Estimating the value of enjoyment of the relational good produced by consumers’ personal relationship in direct sales from farmers is important to assess how much personal interactions can affect food purchases. We employ different stated preferences models to estimate from a consumer survey in open-air markets in four towns in Italy the value consumers buying directly from farmers attach to their particular choice of a specific vendor. Contingent on the chosen model, the average value of the personal relationship is 13.5-24.4% of their expenditure for fruits and vegetables.
Tailoring a solvent-assisted method for solid-supported hybrid lipid–polymer membranes
Creators: name: Di Leone, Stefano
name: Kyropoulou, Myrto
name: Köchlin, Julian
name: Wehr, Riccardo
name: Meier, Wolfgang P.
name: Palivan, Cornelia G.
Publisher: name: American Chemical Society
Year: 2022
Subjects: subject: Polymers
subject: Copolymers
subject: Hydrophobicity
subject: Lipids
subject: Membranes
subject: 600 - Technik, Medizin, angewandte Wissenschaften

description: Combining amphiphilic block copolymers and phospholipids opens new opportunities for the preparation of artificial membranes. The chemical versatility and mechanical robustness of polymers together with the fluidity and biocompatibility of lipids afford hybrid membranes with unique properties that are of great interest in the field of bioengineering. Owing to its straightforwardness, the solvent-assisted method (SA) is particularly attractive for obtaining solid-supported membranes. While the SA method was first developed for lipids and very recently extended to amphiphilic block copolymers, its potential to develop hybrid membranes has not yet been explored. Here, we tailor the SA method to prepare solid-supported polymer–lipid hybrid membranes by combining a small library of amphiphilic diblock copolymers poly(dimethyl siloxane)–poly(2-methyl-2-oxazoline) and poly(butylene oxide)-block–poly(glycidol) with phospholipids commonly found in cell membranes including 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, sphingomyelin, and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(glutaryl). The optimization of the conditions under which the SA method was applied allowed for the formation of hybrid polymer–lipid solid-supported membranes. The real-time formation and morphology of these hybrid membranes were evaluated using a combination of quartz crystal microbalance and atomic force microscopy. Depending on the type of polymer–lipid combination, significant differences in membrane coverage, formation of domains, and quality of membranes were obtained. The use of the SA method for a rapid and controlled formation of solid-supported hybrid membranes provides the basis for developing customized artificial hybrid membranes.
A convenient approach to chiral 4-monosubstituted 1,3-oxazolidine-2-thiones
Creators: name: Lu, Zheng
name: Yang, Yong-Qing
name: Jiu-Hui Li
name: Jun-Nan Wei
name: Yi-Zhu Wang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Chiral 4-monosubstitued 1,3-oxazolidine-2-thiones are regarded as one of the modified version of Evans auxiliaries in asymmetric aldol condensation, which can generate two adjacent chiral carbon centres in one time They have advantages over Evans auxiliaries in some aspects, however their application is highly limited by their preparation approaches as toxic or flammable chemicals are involved. Here, a mild and applicable procedure for preparing the chiral oxazolidine-2-thione auxiliaries has been developed in this article. Potassium ethylxanthate and the corresponding chiral amino alcohols as the starting material in absolute ethanol are mixed and the mixture are heated under reflux for one hour in open air to provide 1,3-oxazolidine-2-thiones chiral auxiliaries in moderate to excellent yields.
The discovery and evaluation of metabolic and epigenetic biomarkers in the diagnosis of epithelial ovarian cancer
Creators: name: Davis, Kayleigh Rebecca
Publisher: name: Imperial College London
Year: 2017

description: Background: Epithelial ovarian cancer (EOC) is often diagnosed late in the advanced stages of the disease with an associated poor prognosis. A large scale multicentre randomised control screening trial, the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), failed to show a significant reduction in mortality in the screening groups using trans-vaginal ultrasound and cancer antigen 125 (CA 125) compared to the no screening group. More sensitive biomarkers for diagnosis of ovarian cancer are a clinical priority. Molecular profiling of ‘liquid biopsies’ has the potential to detect changes associated with the tumour in non-invasively collected blood samples. This study focusses on the use of epigenomics, specifically DNA methylation and metabonomics to identify tumour-specific changes and their performance as diagnostic and prognostic biomarkers in non-invasively collected biofluid. Methods: Differential methylation analysis using the Illumina Infinium® Methylation BeadChip was interrogated to identify candidate methylation biomarkers specific to EOC tumour DNA compared to peripheral blood mononuclear cells (PBMCs). Bisulphite pyrosequencing was used to characterise these biomarkers in tumour and blood. Metabolic profiling techniques including nuclear magnetic resonance (NMR) and mass spectrometry (MS) of blood and urine were used to identify metabolic changes associated with EOC diagnosis and survival. Results: Nine loci differentially methylated between tumour and PBMC DNA, were identified. Methylation of 5/9 candidate loci were shown to be significantly different in prospectively collected plasma samples from patients with high grade serous ovarian cancer (HGSOC) compared to benign/healthy controls with one marker achieving an area under the curve (AUC) of 0.901. Metabonomic analysis of plasma samples identified alterations in amino acid, ketone body and lipid metabolism associated with EOC. Several of these metabolites including tryptophan and beta-hydroxybutyrate were also shown to be significantly associated with overall survival (OS) with hazard ratios of 0.39 (95% CI 0.18-0.83) and 2.76 (95% CI 1.28-5.97) respectively. Conclusions: EOC tumour-specific DNA methylation can be detected in tumour and plasma of EOC cancer patients, providing insight into the biology of the disease and potential as novel diagnostic biomarkers. Metabolic profiling has uncovered a number of candidate EOC biomarkers associated with prognosis. Prospective validation of these biomarkers could help EOC treatment stratification in the future.
CCWI2017: F10 'Online Demand Estimation of Geographical and Non-Geographical Distributed Demand Pattern in Water Distribution Networks'
Creators: name: Do, Nhu Cuong
name: Simpson, Angus R.
name: Deurelein, Jochen W.
name: Piller, Olivier
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The issue of demand calibration and estimation under uncertainty is known to be an exceptionally difficult problem in water distribution system modelling. In the context of real-time event modelling, the stochastic behaviour of the water demands and non-geographical distribution of the demand patterns makes it even more complicated. This paper considers a predictor – corrector approach, implemented by a particle filter model, for solving the problem of demand multiplier factor estimation. A demand forecasting model is used to predict the water demand multiplier factors. The EPANET hydraulic solver is applied to simulate the hydraulic behaviour of a water network. Real time observations are integrated via a formulation of the particle filter model to correct the demand predictions. A water distribution network of realistic size with two configurations of demand patterns (geographically distributed demand patterns and non-geographically distributed demand patterns) are used to evaluate the particle filter model. Results show that the model is able to provide good estimation of the demand multiplier factors in a near real-time context if the measurement errors are small. Large measurement errors may result in inaccurate estimates of the demand values.
Links to GitHub Repositories
Creators: name: Kieft, Kristopher
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Link to Chapter 2 GitHub: https://github.com/AnantharamanLab/Kieft_et_al_2021_organosulfur_AMGs Link to Chapter 3 GitHub: https://github.com/AnantharamanLab/Kieft_and_Zhou_et_al._2020 Link to Chapter 4 GitHub: https://github.com/AnantharamanLab/VIBRANT Link to Chapter 5 GitHub: https://github.com/AnantharamanLab/PropagAtE Link to Chapter 6 GitHub: https://github.com/AnantharamanLab/vRhyme