cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating core genetic-and-epigenetic cell cycle networks for stemness and carcinogenic mechanisms, and cancer drug design using big database mining and genome-wide next-generation sequencing data
Creators: name: Li, Cheng-Wei
name: Bor-Sen Chen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Recent studies have demonstrated that cell cycle plays a central role in development and carcinogenesis. Thus, the use of big databases and genome-wide high-throughput data to unravel the genetic and epigenetic mechanisms underlying cell cycle progression in stem cells and cancer cells is a matter of considerable interest. Real genetic-and-epigenetic cell cycle networks (GECNs) of embryonic stem cells (ESCs) and HeLa cancer cells were constructed by applying system modeling, system identification, and big database mining to genome-wide next-generation sequencing data. Real GECNs were then reduced to core GECNs of HeLa cells and ESCs by applying principal genome-wide network projection. In this study, we investigated potential carcinogenic and stemness mechanisms for systems cancer drug design by identifying common core and specific GECNs between HeLa cells and ESCs. Integrating drug database information with the specific GECNs of HeLa cells could lead to identification of multiple drugs for cervical cancer treatment with minimal side-effects on the genes in the common core. We found that dysregulation of miR-29C, miR-34A, miR-98, and miR-215; and methylation of ANKRD1, ARID5B, CDCA2, PIF1, STAMBPL1, TROAP, ZNF165, and HIST1H2AJ in HeLa cells could result in cell proliferation and anti-apoptosis through NFκB, TGF-β, and PI3K pathways. We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects.
title: The internationalisation of education
title: project implementation and stakeholder interests
titleType: Subtitle
Creators: name: Widin, Jacqueline
Publisher: name: Charles Darwin University
Year: 2005

description: This research took a qualitative case study approach to explore the experiences of working and participating in the implementation of university-led international language education projects. In particular, the research examined project implementation processes from the interviewees' perspective and the subsequent implications for the ways in which the projects' activities were carried out. Data was largely drawn from 25 interviewees in two project sites and also included information gathered from researcher participant observations, project documents, anecdotal accounts and documentation relating to the social contexts in which the projects were established. The research examined the ways in which the different project stakeholders' interests were negotiated and represented and how project benefits were distributed in the field. Pierre Bourdieu's relational concepts of habitus, capital and field and his notion of practice guided the whole research process and they were employed as explanatory devices for both the methodological and theoretical approaches. Of central concern to this study was Bourdieu's notion of interest and his view of the social world as a constant struggle about the symbolic value of practices and artifacts. There were multiple interests in the field which belied its common representation as a binary relationship between the donor or provider and the recipients of the project's 'products'. The research explored the way agents take up or assign dominant or subordinate positions in the field. This research also drew on Critical Discourse Analysis to explore the data and analyse the understandings of project work found in the documents and other written materials as well as the interviews. The research revealed that the work of the international language education projects was complex and the distribution of benefits was masked by the avowed 'disinterest' of the major stakeholders. The concepts of success and failure are closely related to the dominant interests in the field and are pivotal to gaining a greater understanding of the way these projects work. The findings of the research pointed to ways that agents in the field could work towards productive understandings and build more effective collaborative relationships.
Investigating Core Genetic-and-epigenetic Cell Cycle Networks for Stemness and Carcinogenic Mechanisms, and Cancer Drug Design using Big Database Mining and Genome-wide Next-generation Sequencing Data
Creators: name: Li, Cheng-Wei
name: Bor-Sen Chen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Recent studies have demonstrated that cell cycle plays a central role in development and carcinogenesis. Thus, the use of big databases and genome-wide high-throughput data to unravel the genetic and epigenetic mechanisms underlying cell cycle progression in stem cells and cancer cells is a matter of considerable interest. Real genetic-and-epigenetic cell cycle networks (GECNs) of embryonic stem cells (ESCs) and HeLa cancer cells were constructed by applying system modeling, system identification, and big database mining to genome-wide next-generation sequencing data. Real GECNs were then reduced to core GECNs of HeLa cells and ESCs by applying principal genome-wide network projection. In this study, we investigated potential carcinogenic and stemness mechanisms for systems cancer drug design by identifying common core and specific GECNs between HeLa cells and ESCs. Integrating drug database information with the specific GECNs of HeLa cells could lead to identification of multiple drugs for cervical cancer treatment with minimal side-effects on the genes in the common core. We found that dysregulation of miR-29C, miR-34A, miR-98, and miR-215; and methylation of ANKRD1, ARID5B, CDCA2, PIF1, STAMBPL1, TROAP, ZNF165, and HIST1H2AJ in HeLa cells could result in cell proliferation and anti-apoptosis through NFκB, TGF-β, and PI3K pathways. We also identified three drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects.
Bis-N-heterocyclic carbene silver(I) and palladium(II) complexes: Efficient antiproliferative agents against breast cancer cells
Creators: name: Rosenani A. Haque
name: Noorhafizah Hasanudin
name: Mouayed A. Hussein
name: Ahamed, Safa A.
name: Iqbal, Muhammad Adnan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A new Pd(II)-N-heterocyclic carbene (NHC) complex 2 was derived from a binuclear Ag(I)-NHC complex 1. 1H NMR spectra of complexes showed uniquely different characteristic behavior of bridging methylene protons than compared with the ligand. X-ray crystallography showed that palladium at the center of bis-NHC units in 2 was found in square-planar geometry. Ligand and complexes were tested against breast cancer cells (MCF-7). The ligand did not show considerable antiproliferative activity (IC50 181.0 ± 3.0 µM) whereas complexes showed significant activity (1: 0.5 ± 0.1 μM; 2: 2.5 ± 0.2 μM) compared with the standard drug, tamoxifen (2.4 ± 0.2 μM).
India and Intellectual Disability: An Intersectional Comparison of Disability Rights Law and Real Needs
Creators: name: Hamilton, Arthur
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Intellectual disability
Disability rights
Disability legislation
Legal capacity
Inclusive education
Intersectionality
India

description: Given its vast population, India has one of the highest absolute numbers of people with intellectual disability (PwIDs) in the world. Studies have placed the prevalence as high as 3.1% of children aged between 2 to 5 years and 5.2% of children aged between 6 to 9 years. India recently passed the Rights of Persons with Disabilities Act, 2016 (RPwD Act), to align itself with the United Nations Convention on the Rights of Persons with Disabilities. This thesis applied the complementary methods of the review of academic and grey literature, document analysis of the RPwD Act, and in-depth informant interviews to become the first full study on the extent to which the RPwD Act meets the needs of PwIDs. Drawing on the biopsychosocial model of disability and intersectional theory, the findings show that the RPwD Act only partially meets the needs of PwIDs. The RPwD Act does incorporate progressive elements such as affirmative action provisions in the labour market, measures to prevent unethical research on PwIDs, and steps toward inclusive education. However, the Act stipulates a disability certification process that remains mired in the medical model of disability and is mostly inaccessible in rural areas. It also continues the system of legal guardianship dating to the colonial era which deprives many PwIDs of legal capacity and leaves some of them confined to long-term institutions with highly inadequate levels of care. Other problems in the Act include inadequate provisions to provide privacy, reproductive rights and education, and protection from discrimination.
Bis-N-Heterocyclic Carbene Silver(I) and Palladium(II) Complexes: Efficient Antiproliferative Agents against Breast Cancer Cells
Creators: name: Rosenani A. Haque
name: Noorhafizah Hasanudin
name: Mouayed A. Hussein
name: Ahamed, Safa A.
name: Iqbal, Muhammad Adnan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A new Pd(II)-N-Heterocyclic Carbene (NHC) complex 2 was derived from a binuclear Ag(I)-NHC complex 1. 1H NMR spectra of complexes showed uniquely different characteristic behaviour of bridging methylene protons than compared to ligand. X-ray crystallography showed that palladium at the center of bis-NHC units in 2 was found in square planer geometry. Ligand and complexes were tested against breast cancer cells (MCF-7). Ligand did not show considerable antiproliferative activity (IC50 181.0 ± 3.0 µM) whereas complexes showed significant activity (1, 0.5 ± 0.1 μM and 2, 2.5 ± 0.2 μM) compared to the standard drug, Tamoxifen (2.4 ± 0.2 μM).
Presidio Bolson, trans-Pecos Texas and adjacent Mexico: geology of a desert basin aquifer system
Creators: name: Groat, Charles G.
Publisher: name: University of Texas at Austin. Bureau of Economic Geology
Year: 1972
Subjects: Geology -- Mexico -- Chihuahua (State)
Geology -- Texas -- Presidio County

description: Derived from the author's thesis, University of Texas at Austin, 1970, with title: Geology of Presidio Bolson, Presidio County, Texas, and adjacent Chihuahua, Mexico.
Syntheses of new topology BTTB-based metal–organic frameworks in CH3CN/H2O mixed solvents
Creators: name: Weiwei Cheng
name: Tingting Wang
name: Xu, Wei
name: Yuqian Zhang
name: Zhang, Jun
name: Fang, Min
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Three complexes, [Zn2(BTTB)](H2O)5 [BTTB = 4,4′,4″,4′″-benzene-1,2,4,5-tetrayltetrabenzoate, also named 1,2,4,5-tetrakis(carboxyphenyl) benzene] (1), [Cd2(BTTB)(H2O)5](H2O)3 (2) and [Mn2(BTTB)(H2O)5](H2O)2 (3), have been synthesized under hydrothermal conditions in CH3CN/H2O. Structural analyses revealed that 1 has new topologies, i.e. nnu1 (nnu stands for Nanjing Normal University) or nnu2 depending on the different simplification schemes. Compounds 2 and 3 are isostructural and have a scu (square planar and cubical vertices) topology, which have not been reported for BTTB-based metal–organic frameworks. Thermal stability of 1–3, hydrogen adsorption/desorption properties of 2 and 3, and luminescent properties of 1 and 2 were investigated. Compounds 1–3 are stable in air.
title: Appel à candidatures ATRI 2015
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Appel ATRI, diffusé dans le cadre du LabexMed.
Wilcox sandstone reservoirs in the deep subsurface along the Texas Gulf Coast : their potential for production of geopressured geothermal energy
Creators: name: Bebout, Don G.
Publisher: name: University of Texas at Austin. Bureau of Economic Geology
Year: 1982
Subjects: Geology, Stratigraphic -- Eocene
Geothermal resources -- Texas -- Gulf Region
Underground reservoirs

description: Tx Doc no.: Z, UA220.7, R299, no. 117 Accompanied by 3 foldout maps.
Coastal evaporite and tidal-flat sediments of the Upper Clear Fork and Glorieta Formations, Texas Panhandle
Creators: name: Presley, Mark W.
Publisher: name: University of Texas at Austin. Bureau of Economic Geology
Year: 1982
Subjects: Evaporites -- Texas -- Texas Panhandle
Geology -- Stratigraphic -- Permian
Sedimentary Rocks

description: Contract no. DE-AC97-80ET46615.
Syntheses of new topology BTTB-based metal-organic frameworks in CH3CN/H2O mixed solvents
Creators: name: Weiwei Cheng
name: Tingting Wang
name: Xu, Wei
name: Yuqian Zhang
name: Zhang, Jun
name: Fang, Min
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Three complexes, [Zn2(BTTB)](H2O)5 [BTTB = 4,4’,4’’,4’’’-benzene1,2,4,5-tetrayltetrabenzoate, also named 1,2,4,5-tetrakis(carboxyphenyl) benzene] (1), [Cd2(BTTB)(H2O)5](H2O)3 (2) and [Mn2(BTTB)(H2O)5](H2O)2 (3), have been synthesized under hydrothermal conditions in CH3CN/H2O. Structural analyses revealed that 1 has new topologies, i.e. nnu1 (nnu stands for Nanjing Normal University) or nnu2 depending on the different simplification schemes. Compounds 2 and 3 are isostructural and have a scu (square planar and cubical vertices) topology, which have not been reported for BTTB-based MOFs. Thermal stability of 1-3, hydrogen adsorption/desorption properties of 2 and 3 as well as luminescent properties of 1 and 2 were investigated. Compounds 1-3 are stable in air.
title: 02_0665
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Poly(2-hydroxyethyl acrylate) hydrogels containing hyper-branched poly(amidoamine) for sustained drug release
Creators: name: Wenqi Song
name: Yuyang Liu
name: Hou, Yu
name: Xiaodong Fan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Hydrogels containing hyper-branched poly(amidoamine) (hb-PAMAM) microenvironments were suggested for the sustained release of ionizable drugs. For this purpose, a series of poly(2-hydroxyethyl acrylate) (PHEA) hydrogels containing hb-PAMAM (PHEA-hb-PAMAM) were prepared by copolymerization of 2-hydroxyethyl acrylate with acryl-terminated hb-PAMAM. The hb-PAMAM was synthesized by the Michael addition reaction of triacryloylhexahydro-1,3,5-triazine (TT) and piperzaine (PZ). By using nonionic Tegafur and ionizable salicylic acid (SA) as model drugs, the release mechanisms of drugs from PHEA-hb-PAMAM hydrogels were investigated. Compared with the release kinetic of Tegafur, the release rate of SA from the hydrogels was evidently slowed down. Moreover, the release rate of SA can be modulated by the addition of salt. This can be attributed to the ionic interaction of SA with hb-PAMAM microenvironments. By analyzing the release kinetics of SA from the hydrogels, it was found that the release of SA followed non-Fickian diffusion.
Lure of choice revisited: Replication and extensions of Bown et al. (2003)
Creators: name: Yi, Chan Nga
name: Feldman, Gilad
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: choice
subject: decision making
subject: registered report
subject: replication

description: Please see "PCIRR Stage 1" for preprint, Qualtircs survey, and simulated data and code (with all PCIRR review process)
Poly(2-hydroxyethyl methacrylate) hydrogels containing hyperbranched poly(amidoamine) for sustained drug release
Creators: name: Wenqi Song
name: Yuyang Liu
name: Hou, Yu
name: Xiaodong Fan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 60506 Virology
subject: Computational Biology

description: Hydrogels containing hyperbranched poly(amidoamine) (hb-PAMAM) microenvironments were suggested for the sustained release of ionizable drugs. For the purpose, a series of poly(2-hydroxyethyl acrylate) (PHEA) hydrogels containing hb-PAMAM (PHEA-hb-PAMAM) were prepared by copolymerization of 2-hydroxyethyl methacrylate with acryl-terminated hb-PAMAM. The hb-PAMAM was synthesized by Michael addition reaction of triacryloylhexahydro-1,3,5-triazine and piperzaine. By using non-ionic Tegafur and ionizable salicylic acid (SA) as model drugs, the release mechanisms of drugs from PHEA-hb-PAMAM hydrogels were investigated. Compared with the release kinetic of Tegafur, the release rate of SA from the hydrogels was evidently slowed down. Moreover, the release rate of SA can be modulated by the addition of salt. This should attribute to the ionic interaction of SA with hb-PAMAM microenvironments. By analysis of release kinetics of SA from the hydrogels, it was found that the release of SA followed non-Fickian diffusion.
Lithology, microstructures, fluid inclusions, and geochemistry of rock salt and of the cap-rock contact in Oakwood dome, East Texas : significance for nuclear waste storage
Creators: name: Dix, Owen R.
Publisher: name: University of Texas at Austin. Bureau of Economic Geology
Year: 1982
Subjects: Radioactive waste disposal -- Texas
Salt domes -- Texas

description: Project funded by U.S. Dept. of Energy under contract no. DE-AC97-80ET-46617 (formerly contract no. DE-AC97-79ET-46605)
Generation and sampling of nanoscale infectious viral aerosols
Creators: name: Walls, Howard J.
name: Ensor, David S.
name: Harvey, Lauren A.
name: Kim, Jean H.
name: Chartier, Ryan T.
name: Hering, Susanne V.
name: Spielman, Steven R.
name: Lewis, Gregory S.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Airborne viruses represent a potentially significant health threat. However, only recently have researchers begun to characterize the size and infectivity of viral bioaerosols in the nanoscale size range. There are limitations in the generation of test viral aerosols and the ability to sample with acceptable efficiency. Reported here is use of a laminar-flow water condensation method to efficiently sample nanoscale bioaerosols to sizes well below 100 nm. We used MS2 bacteriophage in water to provide an aerosol with particles sizes from 300 nm down to 45 nm for sampling by both an all-glass impinger (4 mm; AGI-4) and the water condensation bioaerosol sampler. We demonstrated the existence of infectious viral particles below 100 nm and a higher collection efficiency by the water condensation sampler compared to the AGI-4 at nanoscale sizes. For example, the water condensation bioaerosol sampler that collected particles at 45 nm in diameter had 20 times more infective virions per collected particle compared to the AGI-4. However, when we corrected the AGI-4 data for particle size–dependent collection efficiency, the results were similar. We also used quantitative reverse transcription polymerase chain reaction, along with culturing for infectivity to determine the percent infectivity of the aerosol by particle size. Finally, we used a simple calculation to determine that a large fraction of sub-100 nm particles did not contain infectious virus because of the low titer concentration of virus in the Collison fluid. © 2016 RTI International
Prima e dopo Afrodite. L'isola al femminile (Musei Reali Torino)
Creators: name: Musei Reali Torino
Publisher: name: Zenodo
Year: 2024

description: La presentazione dal titolo "Prima e dopo Afrodite. L’isola al femminile" si inserisce nell'ambito del ciclo di incontri "Intorno a Cipro. Attività e approfondimenti sulla grande mostra archeologica", nati a margine della mostra "Cipro. Crocevia delle civiltà" (29 ottobre 2021- 29 gennaio 2022, Musei Reali Torino) Cipro. Crocevia delle civiltà - Musei Reali Torino (beniculturali.it)
N,N′-(hexane-1,6-diyl)bis(N-((1-aryl/alkyl-1H-1,2,3-triazol-4-yl)methyl)-4-methyl benzenesulfonamide): Synthesis, antibacterial, antioxidant, and DNA-cleavage activities
Creators: name: Nagavelli Vasudeva Reddy
name: Sirassu Narsimha
name: Lavudya Sudhakar
name: Battula, Kumara Swamy
name: S K Althaf Hussain
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Thirteen novel bis-1,2,3-triazole derivatives were synthesized under copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition of N,N′-(hexane-1,6-diyl)bis(4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide) with different aryl azides and evaluated their biological activity. All the newly synthesized compounds were confirmed by 1H-NMR, infrared, and elemental analysis and mass spectral studies. The synthesized bis-1,2,3-triazoles were evaluated for their antioxidant activity, and some of them were found to exhibit good to excellent antioxidant activity (IC50: 11.13 ± 1.5 to 98.98 ± 1.7 μM) in comparison with standard references, Trolox (11.73 ± 1.5 μM) and ascorbic acid (3.34 ± 1.8 μM). The bistriazoles also exhibited excellent-to-moderate anti-bacterial activity (MIC: 2.253 to 75 µg mL−1 against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa when compared with streptomycin. N,N′-(hexane-1,6-diyl)bis(N-((1-(3,5-dimethylphenyl)-1H-1,2,3-triazol-4-yl)methyl)-4-methyl benzenesulfonamide) has completely cleaved the DNA at a concentration of 100 mg mL−1, and the remaining compounds have partially cleaved the DNA.
Geochemistry of ground water in the Miocene Oakville sandstone : a major aquifer and uranium host of the Texas coastal plain
Creators: name: Henry, Christopher D.
Publisher: name: University of Texas at Austin. Bureau of Economic Geology
Year: 1982
Subjects: Groundwater -- Texas
Uranium -- Texas
Water chemistry

description: Tx Doc no.: Z, UA220.7, R299, no. 118
Protocoll der Concertgesellschaft vom 29 Mai 1829 bis 12 Sept. 1839
Creators: name: Basler Concertgesellschaft
Publisher: name: [s.n.]
Year: 1829

description: Protokolle vom 29. Mai 1829 bis zum 12. Sept. 1839, die meisten überschrieben mit "Commissional Sitzung", einige wenige mit "Allgemeine Sitzung (der Concertgesellschaft)"
description: Concertgesellschaft Basel
description: Allgemeine Musikgesellschaft Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire 2023 HAN-Katalogisierungsregeln rpf
1895/6 : Ausleih-Journal
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1895

description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Oktober 2023 HAN-Katalogisierungsregeln Minimalniveau nach Autopsie
description: Digitalisierung=Digitization=Numérisation Oktober 2023 TIFF
description: Erschliessungsniveau Minimalniveau
Efficacy and safety of LABA/LAMA fixed-dose combinations approved in the US for the management of COPD
Creators: name: Banerji, Donald
name: Mahler, Donald A.
name: Hanania, Nicola A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Introduction: Long-acting β2-agonists [LABAs] and long-acting muscarinic antagonists [LAMAs]) are primary therapies for chronic obstructive pulmonary disease (COPD). Despite improvements in lung function and patient-reported outcomes (PROs) with these therapies, there is room to optimize outcomes further. Combined use of LABAs and LAMAs is recommended when symptoms are not improved with a single agent, and LABA/LAMA fixed-dose combinations (FDCs) are at the forefront of drug development in COPD. Areas covered: This review focusses on the three LABA/LAMA FDCs (indacaterol/glycopyrrolate1 [IND/GLY] 27.5/15.6 µg twice daily, umeclidinium/vilanterol [UMEC/VI] 62.5/25 µg once daily and tiotropium/olodaterol [Tio/Olo] 5/5 µg once daily approved in the US. Phase III clinical trials have shown benefits in lung function, dyspnea and health status with FDCs of IND/GLY, UMEC/VI and Tio/Olo versus placebo and monotherapies. Expert commentary: Data from recent studies of three LABA/LAMA combinations, reviewed here, indicate that dual bronchodilation may be beneficial above and beyond both the monotherapies and LABA/ICS combinations, in providing improvements in lung function and PROs for patients with COPD, which may encourage a shift away from the use of ICS in COPD management, in particular for non-exacerbating patients.
Effects of leptin and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension
Creators: name: Faria, Ana Paula De
name: Ritter, Alessandra M. V.
name: Sabbatini, Andréa R.
name: Modolo, Rodrigo
name: Moreno, Heitor
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Leptin is associated to the lack of blood pressure control as well as target organ damage in resistant hypertensive (RH) subjects. Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic syndrome. We evaluated the association of these two SNPs with clinical and biochemical features in 109 apparent treatment-RH subjects (aTRH) and 125 controlled hypertensives. Homozygous genotypes GG (n = 43) vs. AA (n = 14) for rs7799039 and AA (n = 34) vs. GG (n = 26) genotypes for rs1137101 were compared in aTRH subjects. There was no difference in leptin levels among both SNPs. On the other hand, LEP SNP (GG vs. AA) associated with the levels of glycated haemoglobin (6.4 ± 1.4 vs. 7.8 ± 2.3%, p = 0.03), insulin (8.6 ± 4.6 vs. 30.6 ± 27.7 uUI/mL, p = 0.01), HDL-cholesterol (51 ± 16 vs. 39 ± 11 mg/dL, p = 0.001) and PWV (9.5 ± 2.1 vs. 11.2 ± 2.8 m/s, p = 0.03). LEPR SNP (AA vs. GG), associated with heart rate (69 ± 12 vs. 67 ± 12 bpm, p = 0.03), fat mass (31 ± 11 vs. 24 ± 8 kg, p = 0.03) and triglycerides levels (175 ± 69 vs. 135 ± 75 mg/dL, p = 0.03). These findings may be clinically useful for identifying a group of aTRH who may have a LEP and/or LEPR gene variants, which may predispose this specific group to worse or better outcomes.
Verzeichnis der Musikhandschriften des 18. Jahrhunderts : (Instrumentalmusik) in der Universitätsbibliothek Basel
Creators: name: Refardt, Edgar
Publisher: name: [Universitätsbibliothek]
Year: 1928

description: E. Refardt
description: Typoskript
description: Ist nicht identisch mit Refardt, Edgar: Thematischer Katalog d. Musikhandschriften d. 18. Jhdts. in der Universitätsbibliothek Basel
Correlation of the Ogallala formation (Neogene) in western Texas with type localities in Nebraska
Creators: name: Frye, John Chapman, 1912-
Publisher: name: University of Texas at Austin. Bureau of Economic Geology
Year: 1959
Subjects: Geology -- Nebraska
Geology -- Texas
Geology, Stratigraphic -- Neogene

description: Bibliography: p. [33]-35.
Effects of leptin and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension
Creators: name: Faria, Ana Paula De
name: Ritter, Alessandra M. V.
name: Sabbatini, Andréa R.
name: Modolo, Rodrigo
name: Moreno, Heitor
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Leptin is associated to the lack of blood pressure control as well as target organ damage in resistant hypertensive (RH) subjects. Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic syndrome. We evaluated the association of these two SNPs with clinical and biochemical features in 109 apparent treatment-RH subjects (aTRH) and 125 controlled hypertensives. Homozygous genotypes GG (n = 43) vs. AA (n = 14) for rs7799039 and AA (n = 34) vs. GG (n = 26) genotypes for rs1137101 were compared in aTRH subjects. There was no difference in leptin levels among both SNPs. On the other hand, LEP SNP (GG vs. AA) associated with the levels of glycated haemoglobin (6.4 ± 1.4 vs. 7.8 ± 2.3%, p = 0.03), insulin (8.6 ± 4.6 vs. 30.6 ± 27.7 uUI/mL, p = 0.01), HDL-cholesterol (51 ± 16 vs. 39 ± 11 mg/dL, p = 0.001) and PWV (9.5 ± 2.1 vs. 11.2 ± 2.8 m/s, p = 0.03). LEPR SNP (AA vs. GG), associated with heart rate (69 ± 12 vs. 67 ± 12 bpm, p = 0.03), fat mass (31 ± 11 vs. 24 ± 8 kg, p = 0.03) and triglycerides levels (175 ± 69 vs. 135 ± 75 mg/dL, p = 0.03). These findings may be clinically useful for identifying a group of aTRH who may have a LEP and/or LEPR gene variants, which may predispose this specific group to worse or better outcomes.
Trophic strategies of Yellow-legged Gull Larus michahellis on oceanic islands surrounded by deep waters
Creators: name: López, Heriberto
name: Pérez, Antonio J.
name: Rumeu, Beatriz
name: Nogales, Manuel
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Capsule: The diet of Yellow-legged Gulls Larus michahellis on an oceanic island, surrounded by deep waters without a wide shelf, was mainly composed of terrestrial invertebrates. Aims: To study the trophic ecology of Yellow-legged Gulls on an island surrounded by deep waters, to quantify the importance of terrestrial prey items and their availability, and to evaluate the relative importance of nutritional values of terrestrial and marine resources. Methods: Diet was monitored for one year. We assessed the relative contribution of the main prey items and their macronutrients through the study of pellets and faeces. Results: Terrestrial invertebrates were the most frequently consumed prey items (frequency of occurrence (FO) 67%), followed by marine fish (Osteichthyes FO 33%). Coleoptera and Orthoptera were the most consumed terrestrial invertebrates and provided a high nutritional value. The rate of consumption of terrestrial invertebrates varied in synchrony with the breeding season, being higher in spring, indicating their potential importance for reproduction. Conclusion: It is unusual that terrestrial invertebrates constitute a large proportion of the diet of large gulls, but they seemed to cover their trophic energy requirements during the reproductive period.
Solvent-dependent structural diversity of cadmium(II) coordination polymers: syntheses, characterizations, and luminescence properties
Creators: name: Qin, Liang
name: Lu, Kuan
name: Zheng, Zhao-Yang
name: Dong-Ting Lin
name: Zhao, Ji-Jun
name: Ma, De-Yun
name: Liang, Feng-Lan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Plant Biology

description: By changing the solvent, three cadmium(II) coordination polymers (CPs), [Cd(NH2-BDC)(DMA)(H2O)]n (1), {[Cd(NH2-BDC)2(DMF)2]·H2O}n (2) and {[(Me2NH2)2Cd2(NH2-BDC)3(H2O)]·DMF·8H2O}n (3), have been synthesized based on the V-shaped linker 5-aminoisophthalic acid and Cd(NO3)2·4H2O under the same reaction temperature (140 °C) (NH2-BDC = 5-aminoisophthalate, DMA = N,N-dimethylacetamide, DMF = N,N-dimethylformamide). Compound 1 features a 1-D ladder-like infinite chain. Compound 2 is a 2-D (4,4) net when the dinuclear [Cd2(COO)4O4] is regarded as a quadruply-connected node. Compound 3 shows a 2-D hamburger-like structure. Luminescent properties of 1–3 were detected at room temperature under the same excitation and emission wavelengths of 200–600 nm with the same interval of 5 nm. Moreover, the calculation of lattice constants and volumes, and density of states of CPs 1 and 2 were carried out to get better insight into the nature of the structure and luminescence.
title: The role of knowledge sharing in the use of pedagogical discussion cases
title: an empirical study
titleType: Subtitle
Creators: name: Sriratanaviriyakul, Narumon
Publisher: name: Charles Darwin University
Year: 2018

description: In today’s rapidly changing economy, graduates are expected to be more knowledgeable and well-prepared than ever before. Pedagogical discussion cases, problem-based learning tools, are designed to improve students’ learning using their prior knowledge and accumulating additional soft skills. The aim of the thesis was to investigate the role of discussion cases on improving the knowledge sharing among students working in groups and to provide empirical evidences to support it. The framework used was developed from current literary research. The thesis introduced a survey adopted from literary existing instruments and used similar constructs to collect data on the environmental factors, motivational factors, individual’s characteristics, lecturer’s role, industry representative’s role and knowledge sharing to report on their effects on the students’ learning experiences and learning outcomes. The scales were measured using the seven-point Likert scale based on the respondents’ level of agreement. The framework was analyzed using Structure Equation Modelling through SPSS AMOS. The results, based on statistical significance (the p-value ˂ 5%), showed that some of the environmental factors positively influenced the students’ knowledge sharing motivations. In addition, the industry representative’s (case protagonist) active involvement in the classroom had significant impact on the students’ knowledge sharing behaviors and that his/her role is a motivator for knowledge transfer among the students. The results also demonstrated that the students’ motivation to share knowledge was not necessarily linked to their intention to share knowledge. Also, despite the lecturer’s positive characteristics and the students’ strong positive opinion of the lecturer, the students lack the motivation to share or even change their behaviors towards sharing. Another fundamental observation of the thesis is that knowledge sharing in the classroom is different from that in the workplace and that a change of the classroom culture towards a cooperative environment is integral for a motivational, behavioral and intentional change to sharing.
Solvent-dependent structural diversity of cadmium(II) coordination polymers: Syntheses, characterizations, and luminescence properties
Creators: name: Qin, Liang
name: Lu, Kuan
name: Zheng, Zhao-Yang
name: Dong-Ting Lin
name: Zhao, Ji-Jun
name: Ma, De-Yun
name: Liang, Feng-Lan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Plant Biology

description: By changing the solvent, three cadmium(II) coordination polymers, [Cd(NH2-BDC)(DMA)(H2O)]n (1), {[Cd(NH2-BDC)2(DMF)2]·H2O}n (2) and {[(Me2NH2)2Cd2(NH2-BDC)3(H2O)]·DMF·8H2O}n (3), have been synthesized based on the V-shaped linker 5-aminoisophthalic acid and Cd(NO3)2·4H2O under the same reaction temperature (140 °C) (NH2-BDC = 5-aminoisophthalate, DMA = N,N-dimethylacetamide, DMF = N,N-dimethylformamide). Compound 1 features a 1D ladder-like infinite chain. Compound 2 is a 2D (4,4) net when the dinuclear [Cd2(COO)4O4] is regarded as a quadruply-connected node. Compound 3 shows a 2D hamburger-like structure. Luminescent properties of 1-3 were detected at room temperature under the same excitation and emission wavelengths of 200-600 nm with the same interval of 5 nm. Moreover, the calculation of lattice constants and volumes, and density of states (DOS) of CPs 1 and 2 were carried out to get better insight into the nature of the structure and luminescence.
title: 01_0955
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Berberis aristata Ameliorates Adjuvant-Induced Arthritis by Inhibition of NF-κB and Activating Nuclear Factor-E2-related Factor 2/hem Oxygenase (HO)-1 Signaling Pathway
Creators: name: Rohit Kumar
name: Nair, Vinod
name: Gupta, Yogendra Kumar
name: Singh, Surender
name: S. Arunraja
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: The present study was carried out to investigate the anti-arthritic activity of Berberis aristata hydroalcoholic extract (BAHE) in formaldehyde-induced arthritis and adjuvant-induced arthritis (AIA) model. Arthritis was induced by administration of either formaldehyde (2% v/v) or CFA into the subplantar surface of the hind paw of the animal. In formaldehyde-induced arthritis and AIA, treatment of BAHE at doses 50, 100 and 200 mg/kg orally significantly decreased joint inflammation as evidenced by decrease in joint diameter and reduced inflammatory cell infiltration in histopathological examination. BAHE treatment demonstrated dose-dependent improvement in the redox status of synovium (decrease in GSH, MDA, and NO levels and increase in SOD and CAT activities). The beneficial effect of BAHE was substantiated with decreased expression of inflammatory markers such as IL-1β, IL-6, TNF-R1, and VEGF by immunohistochemistry analysis in AIA model. BAHE increased HO-1/Nrf-2 and suppressed NF-κB mRNA and protein expression in adjuvant immunized joint. Additionally, BAHE abrogated degrading enzymes, as there was decreased protein expression of MMP-3 and -9 in AIA. In conclusion, we demonstrated the anti-arthritic activity of Berberis aristata hydroalcoholic extract via the mechanism of inhibition of NF-κB and activation of Nrf-2/HO-1.
The single evolutionary origin of chlorinated auxin provides a phylogenetically informative trait in the Fabaceae
Creators: name: Lam, Hong Kiat
name: Ross, John J.
name: McAdam, Erin L.
name: McAdam, Scott A. M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Chlorinated auxin (4-chloroindole-3-acetic acid, 4-Cl-IAA), a highly potent plant hormone, was once thought to be restricted to species of the tribe Fabeae within the Fabaceae, until we recently detected this hormone in the seeds of Medicago, Melilotus and Trifolium species. The absence of 4-Cl-IAA in the seeds of the cultivated species Cicer aeritinum from the Cicerae tribe, immediately basal to the Fabeae and Trifolieae tribes, suggested a single evolutionary origin of 4-Cl-IAA. Here, we provide a more robust phylogenetic placement of the ability to produce chlorinated auxin by screening key species spanning this evolutionary transition. We report no detectable level of 4-Cl-IAA in Cicer echinospermum (a wild relative of Cicer aeritinum) and 4 species (Galega officinalis, Parochetus communis, Astragalus propinquus and A. sinicus) from tribes or clades more basal or sister to the Cicerae tribe. We did detect 4-Cl-IAA in the dry seeds of four species from the genus Ononis that are either basal to the genera Medicago, Melilotus and Trigonella or basal to, but still within, the Fabeae and Trifolieae (ex. Parochetus) clades. We conclude that the single evolutionary origin of this hormone in seeds can be used as a phylogenetically informative trait within the Fabaceae.