cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Progesterone receptor is a significant factor associated with clinical outcomes and effect of adjuvant tamoxifen therapy in breast cancer patients
Creators: name: Liu, Shuzhen
name: Chia, Stephen
name: Mehl, Erika
name: Leung, Samuel
name: Cheang, Maggie Chong U.
name: Nielsen, Torsten
Publisher: name: Springer
Year: 2021

description: Purpose: Estrogen receptor status in breast cancer is associated with response to hormonal therapy and clinical outcome. The additional value of progesterone receptor (PR) has remained controversial. We examine the value of PR for prognosis and response to tamoxifen on a population-based series of 4,046 invasive early stage breast cancer patients. Methods: Clinical information for age at diagnosis, stage, pathology, treatment and outcome was assembled for the study cohort; the median follow-up was 12.4 years. PR status was determined by immunohistochemistry using a rabbit monoclonal antibody on tissue microarrays built from breast tumor surgical excisions. Survival analyses, Kaplan-Meier functions and Cox proportional hazards regression models were applied to assess the associations between PR and breast cancer specific survival. Results: Progesterone receptor was positive in 51% of all cases and 67% of estrogen receptor positive (ER+) cases. Survival analyses for both the whole cohort and ER+ cases given tamoxifen therapy showed that patients with PR+ tumors had 24% higher relative probability for breast cancer specific survival as compared to PR- patients, adjusted for ER, HER2, age at diagnosis, grade, tumor size, lymph node status and lymphovascular invasion covariates. Higher PR expression showed stronger association with patient survival. Log-likelihood ratio tests of multivariate Cox proportional hazards regression models demonstrated that PR was an independent statistically significant factor for breast cancer specific survival in both the whole cohort and among ER+ cases treated with tamoxifen. Conclusion: PR adds significant prognostic value in breast cancer beyond that obtained with estrogen receptor alone.
Acanthiza tanami Mathews
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Acanthizidae
Acanthiza
Acanthiza tanami

description: Acanthiza tanami Mathews
 Acanthiza tanami Mathews, 1912a: 349 (Northern Territory (Tanami)).
 Now Acanthiza apicalis whitlocki North, 1909. See Schodde and Mason, 1999: 201–203.
HOLOTYPE: AMNH 600595, adult female, collected on the Tanami Goldfield, 1300 ft, 19.58S, 129.42E (Storr, 1977: 113), Northern Territory, Australia, on 4 March 1910, by J.P. Rogers (no. 566A). From the Mathews Collection (no. 5139) via the Rothschild Collection.
 COMMENTS: Mathews cited his catalog number of the holotype in the original description. In addition to Rogers’ label, the specimen bears Mathews and Rothschild type labels and a yellow ‘‘Figured’’ label, indicating that it was illustrated in Mathews (1922a: pl. 447, right-hand fig., opp. p. 409, text p. 414), where it is confirmed as the type of tanami. Apparently he had the single specimen.
 Mayr and Serventy (1938: 264) mentioned the ‘‘unique type’’, and Mayr (1986b: 436) recognized Acanthiza apicalis tanami.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on pages 155-156, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
The Impact of Employee motivation on employee performance: The case of selected private commercial banks at Debre Berhan.
Creators: name: YONATAN, FEKADU
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The main aim of this study is to undergo a research on the impact of motivation on employee performance in case of selected private commercial banks which are found in Debre Berhan town. This enables to understand the needs of employees to their intended objectives. Motivation plays a vital role nowadays in worldwide, for the organization in order to achieve their goal different motivational factor should be included to get the desired outcome. If the organization has motivated employees it is as such easy to meet the desired objective. So that it is important for the organization to create motivational program that improve motivation and consequently the performance of the organization and the employees. Census sampling techniques used for the study; hence all employee of selected private banks is included. Primary date was collected through questionnaires from the employees of different private commercial bank in Debre Berhan town. To undergo this research quantitative analysis method was applied, to analysis the data using statistical package for social science (SPSS) software version 25.the data is presented in descriptive and inferential statistics. Secondary data was collected from different book journal researches. Survey data collected from respondents analyzed using descriptive, correlation and regression analysis. This study revealed that management of the organization should be implemented different motivational strategies to motivate their employee in baking industry. The correlation result shows that there is a positive and significant relationship between all employee motivation factors and employee performance.
Acanthiza chrysorrhoa subsp. sandlandi Mathews
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Acanthizidae
Acanthiza
Acanthiza chrysorrhoa
Acanthiza chrysorrhoa sandlandi mathews

description: Acanthiza chrysorrhoa sandlandi Mathews
 Acanthiza chrysorrhoa sandlandi Mathews, 1912a: 351 (Victoria).
 Now Acanthiza chrysorrhoa leighi Ogilvie-Grant, 1909. See Schodde and Mason, 1999: 212–213.
HOLOTYPE: AMNH 601067, adult male, collected at Blackburn, 37.49S, 145.10E (USBGN, 1957b), Victoria, Australia, on 9 July 1910, by Thomas H. Tregellas. From the Mathews Collection (no. 1994) via the Rothschild Collection.
COMMENTS: Mathews cited his catalog number of the holotype in the original description. In addition to the field label, the holotype bears Mathews and Rothschild type labels. AMNH 601068 (Mathews no. 1993), male, 12 December 1908, and AMNH 601069 (5095) male, 9 March 1909, both collected at Frankston by Tregellas, are paratypes.
 Mathews (1913a: 218) specified the type locality of sandlandi as Blackburn, the collecting locality of the holotype. Mayr (1986b: 437) recognized sandlandi and synonymized leighi with nominate chrysorrhoa. Schodde and Mason (1999: 213) recognized leighi and synonymized sandlandi with it.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 158, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Measuring health-related quality of life in tuberculosis: a systematic review
Creators: name: Guo, Na
name: Marra, Fawziah
name: Marra, Carlo A.
Publisher: name: BioMed Central
Year: 2016

description: Introduction: Tuberculosis remains a major public health problem worldwide. In recent years, increasing efforts have been dedicated to assessing the health-related quality of life experienced by people infected with tuberculosis. The objectives of this study were to better understand the impact of tuberculosis and its treatment on people's quality of life, and to review quality of life instruments used in current tuberculosis research. Methods: A systematic literature search from 1981 to 2008 was performed through a number of electronic databases as well as a manual search. Eligible studies assessed multi-dimensional quality of life in people with tuberculosis disease or infection using standardized instruments. Results of the included studies were summarized qualitatively. Results: Twelve original studies met our criteria for inclusion. A wide range of quality of life instruments were involved, and the Short-Form 36 was most commonly used. A validated tuberculosis-specific quality of life instrument was not located. The findings showed that tuberculosis had a substantial and encompassing impact on patients' quality of life. Overall, the anti-tuberculosis treatment had a positive effect of improving patients' quality of life; their physical health tended to recover more quickly than the mental well-being. However, after the patients successfully completed treatment and were microbiologically 'cured', their quality of life remained significantly worse than the general population. Conclusion: Tuberculosis has substantially adverse impacts on patients' quality of life, which persist after microbiological 'cure'. A variety of instruments were used to assess quality of life in tuberculosis and there has been no well-established tuberculosis-specific instrument, making it difficult to fully understand the impact of the illness.
title:  La certificazione della parità di genere: interesse generale, normazione volontaria e disciplina pubblicistica
Creators: name: Lazzara, Paolo
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2025

description: Il saggio analizza il «Sistema di certificazione della parità di genere», a partire dalla prassi di riferimento UNI/PdR 125:2022. L’analisi valorizza l’attività di normazione volontaria dell’Ente nazionale di normazione (UNI) che elabora, pubblica e diffonde norme tecniche che diventano riferimenti condivisi per la generalità delle categorie interessate. Tale apparato normativo funge da grande piattaforma partecipativa a disposizione del Paese, delle imprese, delle istituzioni, delle associazioni e dei cittadini, e restituisce un patrimonio di conoscenze e di valori che è insieme utile, pratico ed etico.

This paper examines the normative instruments and policies introduced in Italy over the past few years for the purpose of furthering gender equality in the workplace.
description: ἀγλαὰ δῶρα. Studi miscellanei in onore di Dora Faraci
Europe and India: The Need for Greater Mutual Awareness
Creators: name: Rothermund, Dietmar
Publisher: name: Asien
Year: 2020

description: The EC is poised to accept several East-European states as new members. In this way it will be preoccupied with its own integration and will not pay much attention to developments in distant places such as India. A consolidated "Little Europe" would certainly be more effective in dealing with the outside world, but it seems that nobody in Europe would opt for a minimal solution — least of all the East Europeans who wish to join the EC as soon as possible.
description: Asien, Nr. 80 (2001): ASIEN (Juli)
China’s ’’Government Online” and Attempts to Gain Technical Legitimacy
Creators: name: Zhang, Junhua
Publisher: name: Asien
Year: 2020

description: China's "Government Online Project", launched in 1999, illustrates the ambition of the Chinese Communist Party (CCP) to set up an e-government. However, the real motivation behind this project is much more than just the sole establishment of service-oriented government websites. The CCP also hopes to gain technical legitimacy in the process. By highlighting the development of this project, which has not been widely publicised, and by revealing the problems the CCP encountered with it, the author attempts to prove that the CCP's endorsement of a new digital world is an attempt to gain technical legitimacy. Through such an analysis, the author also shows that because the CCP plays an increasingly proactive role as well as a reactive one, a contradiction between the need to achieve technical legitimacy and Chinese utilitarianism exists.
description: Asien, Nr. 80 (2001): ASIEN (Juli)
NGO, Frauen und China
Creators: name: Sausmikat, Nora
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Die so genannten "Minjian"-Organisationen oder "shehui tuanti" (wortlich: Mitglie- dergemeinschaften, vgl. Young 1999-2000: 12; Saich 2000: 124) gelten gemeinhin in China als NGO/NPO-Kdrper. Nach Saich umschlieBt dieser Begriff sowohl autonome (d.h. auch finanziell autonome) Vereinigungen als auch durch Staatseinheiten aufgebaute Organisationen, die als Wohlfahrtseinrichtungen fungieren sollen.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 80 (2001): ASIEN (Juli)
Hainanprojekt und die Grenzen zentralstaatlicher Reformpolitik in der Volksrepublik China
Creators: name: Gottwald, Jörn-Carsten
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Die chinesische Insel Hainan erlebte in den 1980er und 1990er-Jahren einen kometenhaften Aufstieg mit raschem anschlieBenden Niedergang. Als wirtschaftlich vollig unterentwickelter Teil der Provinz Guangdong wurde Hainan zum Schauplatz des wichtigsten Experiments einer politisch-administrativen und wirtschaftlichen Strukturreform innerhalb der Volksrepublik China.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 80 (2001): ASIEN (Juli)
Wirtschaftspolitik und State-Building: Die nationalchinesische Industrialisierungspolitik in historischer Perspektive
Creators: name: Meyer, Michael
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Die asiatische Finanz- und Wirtschaftskrise der Jahre 1997/98 markierte einen Wendepunkt in der Diskussion um die weltwirtschaftlich lange Zeit dynamischste Region. Insbesondere stellte sie die Vorstellung eines so genannten "ostasiatischen Modells", welche die Debatte seit etwa Mitte der 1980er-Jahre beherrscht hatte, in ein anderes Licht. Deren Vertreter waren davon ausgegangen, in Ostasien eine von der "westlichen" Variante distinktive Form der kapitalistischen Marktwirtschaft vorzufinden.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 80 (2001): ASIEN (Juli)
chinesische Aktienmarkt: Staatliche Regulierung im Wandel
Creators: name: Heilmann, Sebastian
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Diese Studie widmet sich Fragen der Aktienmarktregulierung in einem der wichtigsten emerging markets. Die erst zu Beginn der neunziger Jahre gegründeten chinesischen Börsen in Shanghai und Shenzhen erreichten Ende des Jahres 2000 zusammen eine Marktkapitalisierung von rund 581 Milliarden US-Dollar und blieben damit zwar noch etwas unter dem Niveau des Hongkonger Aktienmarktes, übertrafen aber bei weitem die Marktkapitalisierung der taiwanischen Börse. Entgegen dem globalen Trend verzeichneten die - intemationalen Investoren weitgehend verschlossenen - Markte in Shanghai und Shenzhen im Jahr 2000 massive Kursgewinne. Und für das Jahr 2001 wurde prognostiziert, dass die Volksrepublik China allein ungefähr ein Viertel der weltweiten privaten Kapitalinvestitionen in aufstrebende Markte anziehen werde.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 80 (2001): ASIEN (Juli)
ASSESSMENT OF PROCUREMENT PRACTICE AND ITS EFFECT ON OPERATIONAL EFFICIENCY IN THE CASE OF DEBRE BERHAN UNIVERSITY
Creators: name: SEWINET, BELETE
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: This study aimed to assess procurement practice and its effect on operational efficiency a case of Debre Berhan University. The study adopted both Descriptive and Explanatory method of research since the study intended to explain cause and effect relationship between procurement practice and operational efficiency in DBU. Specifically, the study sought to examine the variables procurement planning, use of IT, staff competency, procurement follow-up mechanisms and procurement process that affect the performance of procurement. The study employed purposive sampling technique to select the respondents. The target population of the study was 2000 academic and administration staffs of DBU and the sample size of the study was 192 respondents who are currently working at different management positions and have direct and indirect relationship with procurement activities. A structured questionnaire were used as a data collection instrument. A statistical package for social science version 20.0 was used for data analysis. From the study findings it was concluded that procurement practice have effect on operational efficiency in DBU thus the researcher recommended that the organization management should give attention to procurement planning to reduce delays in procurement process, to give training and build the capacity of procurement staffs, use IT for to facilitate procurement activities, strengthen audit and inspection work, use the process of procurement to enhance accountability and transparency.
Accumulation of persistent organic pollutants in trout from the Canadian Rocky Mountains
Creators: name: Demers, Marc J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Ecology.

description: The accumulation of persistent organic pollutants (POPs) in mountain regions was investigated by collecting trout from eight lakes spanning an elevation gradient of 760 to 2360 m.a.s.l. in the Canadian Rocky Mountains. All lakes were located within (or close to) national parks in Alberta and British Columbia. Concentrations of several organochlorine compounds increased significantly with lake elevation. The compounds, which increased the most with elevation, were the less volatile organochlorine pesticides (OCPs) (e.g. dieldrin, DDTs). The relationship was not as strong for the more volatile organochlorines (e.g. HCHs, HCB). Biological factors such as growth dilution of contaminants appears to be a major determinant of contaminant concentrations of organochlorine compounds in alpine lakes. Principal component analysis (PCA) showed that POP composition in trout relate strongly to octanol/water partition co-efficient (Kow) and lake elevation.
Rückzug des Staates aus dem chinesischen Mediensektor? Neue institutionelle Arrangements am Beispiel des Zeitungsmarktes
Creators: name: Fischer, Doris
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Der Mediensektor als Wirtschaftsbranche weist einige Besonderheiten auf. Diese Besonderheiten sind auf mehrere Faktoren zurückzuführen: Zum einen haben Inhalte von Massenmedien in gewisser Hinsicht den Charakter eines öffentlichen Gutes. Des Weiteren treten die meisten Medienfirmen auf zwei Märkten auf. Neben dem Konsumentenmarkt für Medieninhalte bewegen sie sich in einem Markt, in dem sie ihre "Inhaltskunden" bündeln und als Publikum an die Werbewirtschaft verkaufen. Medien sind Informations- und Werbeträger zugleich. Ein drittes Charakteristikum ist die gegenseitige Beeinflussung der beiden Märkte. Die Intensität, mit der Konsumenten ein Medienprodukt konsumieren, wird beeinflusst von der Menge der Werbung, die darin enthalten ist. Die Attraktivitat der Konsumenten (- gruppe) für die Werbewirtschaft kann wiederum Einfluss darauf haben, wie viel eine Medienfirma bereit ist, in die Inhalte eines Medienproduktes zu investieren (Wild- mann 1998: 2f.)
description: ASIEN: The German Journal on Contemporary Asia, Nr. 80 (2001): ASIEN (Juli)
FACTORS AFFECTING EMPLOYEES SATISFACTION: THE CASE OF COMMERCIAL BANK OF ETHIOPIA AT DEBRE BERHAN TOWN
Creators: name: SINDU, ZEWDIE
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The main objective of the present study was to investigate the factors affecting employees" satisfaction among Commercial Bank of Ethiopia employees in Debre Berhan town. The study utilized both descriptive and explanatory research designs, with a questionnaire adapted from previous studies, pilot tested and reliability measured with Cronbach"s Alpha; used as data gathering instruments. Sample size of 137 employees was used to complete the study. Descriptive analyses were used to express the socio demographic characteristics of employees using frequencies and proportions, and the job satisfaction of employees using means. Correlation analysis was used to test hypotheses. A multiple linear regression model was specified, tested for the assumptions and used to fit the six independent factors and the dependent factor, and finally used to determine the most affecting factor that influence overall job satisfaction of employees. All of the six factors; workplace environment, reward and recognition, promotion, salary and benefit, job safety and security, and training and development showed positive relationship with the overall job satisfaction of employees. The multiple linear regression model analyses revealed as workplace environment and job safety and security were the two most contributors of employees" overall job satisfaction, but no significant contribution was made regarding reward and recognition. Salary and benefit, and Promotion made moderate contribution while the least contributor was training and development.
Factors Affecting thePerformance of Micro and Small Enterprises in Debre Berhan Town
Creators: name: Tekabe, Shewakena
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: The aim of this study was to investigate factors affecting the performance of small and micro enterprises (MSEs), with a special focus on textile and garment, food processing and wood and metal work sectors in Debre Brehan, Ethiopia. For this purpose, the study employed mixed methods cross sectional survey research design in which both quantitative and qualitative methods were used for collection and analysis of data obtained from sampled respondents. Purposive sampling, comprehensive sampling and stratified sampling techniques were used for selecting Debre Berhan Town as the research setting, nine kebeles in Debre Berhan Town, and 150 SMEs respondent operators in Debre Berhan Tow, respectively. Using an adapted questionnaire comprising open-ended questions, close-ended questions and Liker scales, quantitative data were gathered from a sample of 150 respondent SMEs operating in Debre Berhan town. In addition, with the use of face-to-face interview, quantitative data were gathered from 20 SMEs operators randomly chosen from the 150 SEMs operators. The quantitative data gathered from the respondents were analyzed using descriptive and inferential statistical procedures. The interview data were also analyzed using descriptive narrations through concurrent triangulation strategy. The findings revealed that there are eight major challenges which are believed to have a negative influence on the performance of SMEs operating in Debre Berhan Town. The challenges include inadequate finance, lack of working premises, marketing problems, inadequate infrastructures, poor management practices, and technological, entrepreneurial and politico-legal problems including bureaucratic bottlenecks system. The study also indicated there existed a significant positive linear relationship between factors (technological, financial, market linkage, infrastructural and management aspects) imping that these factors adversely affected the performance of the MSEs. Based on the findings, recommendations are offered to pertinent government bodies and operators of MSEs for action and practice, and to future research.
Acanthiza chrysorrhoa subsp. perksi Mathews
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Acanthizidae
Acanthiza
Acanthiza chrysorrhoa
Acanthiza chrysorrhoa perksi mathews

description: Acanthiza chrysorrhoa perksi Mathews
 Acanthiza chrysorrhoa perksi Mathews, 1912a: 351 (South Australia).
 Now Acanthiza chrysorrhoa leighi Ogilvie-Grant, 1909. See Schodde and Mason, 1999: 212–213.
HOLOTYPE: AMNH 601065, adult male, collected on the Mount Lofty Ranges, 35.00S, 138.50E (USBGN, 1957b), South Australia, Australia, on 25 July 191l, by S.A. White (no. 181). From the Mathews Collection (no. 9303) via the Rothschild Collection.
 COMMENTS: Mathews cited his catalog number of the holotype in the original description. It was the only specimen of chrysorrhoa cataloged at that time, and there were no other Mathews specimens from South Australia that came to AMNH. In addition to White’s label, it bears Mathews and Rothschild type labels.
 Mathews (1913a: 218) specified the type locality as the Mount Lofty Ranges, the collecting locality of the holotype. Mayr (1986b: 438) recognized sandlandi and synonymized perksi with it. Schodde and Mason (1999: 213) synonymized sandlandi (including perksi) with leighi.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 158, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Optimizing assessment and treatment for hepatitis C virus infection in illicit drug users : a novel model incorporating multidisciplinary care and peer support
Creators: name: Grebely, Jason
name: Knight, Elizabeth
name: Genoway, Krista
name: Viljoen, Mark
name: Khara, Milan
name: Elliot, Doug
name: Gallagher, Lesley
name: Storms, Michelle
name: Raffa, Jesse Daniel
name: DeVlaming, Stanley
name: Duncan, Fiona
name: Conway, Brian
Publisher: name: The University of British Columbia
Year: 2017

description: OBJECTIVES: We evaluated assessment and treatment for hepatitis C virus (HCV) among illicit drug users accepting referral to a weekly HCV peer-support group at a multidisciplinary community health centre. METHODS: From March 2005 to 2008, HCV-infected individuals were referred to a weekly peer-support group and assessed for HCV infection. A retrospective chart review of outcomes 3 years after the initiation of the group was conducted (including HCV assessment and treatment). RESULTS: Two hundred and four HCV antibody-positive illicit drug users accepted referral to a weekly HCV peer-support group. Assessment for HCV occurred in 53% of patients(n= 109), with 13% (n= 14) having initiated or completed treatment for HCV infection before attending the support group, evaluation ongoing in 10% (n= 11) and treatment deferred/not indicated in 25% (n= 27). The major reasons for HCV treatment deferral included early disease (30%),drug dependence (37%), other medical (11%) or psychiatric comorbidities (4%). Sixty-eight percent of those deferred for reasons other than early liver disease showed multiple reasons for treatment deferral. The first 4 weeks of support group attendance predicted successful HCV assessment (odds ratio: 6.03, 95% confidence interval:3.27-11.12, P < 0.001). Overall, 28% (n= 57) received treatment. Among individuals having completed pegylated-interferon and ribavirin therapy with appropriate follow-up (n =19), the rate of sustained virologic response was 63% (12/19), despite illicit drug use in 53%. CONCLUSION: A high proportion of illicit drug users accepting referral to a weekly HCV peer-support group at a multidisciplinary health centre were assessed and treated for HCV infection. Peer support coupled with multidisciplinary care is an effective strategy for engaging illicit drug users in HCV care.
Regulatory mechanisms controlling distal-less related gene expression in lamprey
Creators: name: Maurya, Ashish K
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Molecular.
subject: Biology, Genetics.

description: Vertebrate Dlx genes code for homeodomain (a conserved DNA binding domain) transcription factors involved in the development of the forebrain, craniofacial skeleton, dentition, sensory organs and limbs. Vertebrates have at least 6 Dlx genes whereas invertebrates have only one Dlx homologue (called the distal-less or Dll gene) (Stock, Ellies et al. 1996). Vertebrate Dlx genes are organized as pairs of convergently transcribed genes. The intergenic region between each of these bigenes contains at least two highly conserved sequences (300-500bp each) that act as enhancers of transcription of the flanking Dlx genes. Activity of these enhancers when tested with reporter genes (GFP and LacZ) in transgenic zebrafish and mice recapitulates the endogenous Dlx expression patterns. Here we are investigating Dlx regulation in lamprey, an agnathan species and a sister group of gnathostomes. In doing this we hope to (1) trace back the origin of the conserved Dlx intergenic enhancers found in vertebrates and (2) address the question, can the differences in regulation of lamprey Dlx genes with that of gnathostomes account for some of the morphological differences seen in lampreys (like absence of jaws)? We have shown that lamprey have at least four Dlx genes (A, B, C, D), two of which are arranged in the bigenic configuration seen in other vertebrates. We were unable to find the presence of the conserved intergenic enhancers by Southern hybridization and PCR experiments within this lamprey Dlx intergenic region. We have shown that this region can target expression of reporter genes in the forebrain, branchial arches and trunk somites when tested in zebrafish embryos in a reporter gene assay, suggesting many of the Dlx regulatory mechanisms are conserved between lamprey and gnathostomes.
Schémas de discrétisation en temps pour le modèle bidomaine
Creators: name: Éthier, Marc
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Mathematics.

description: The bidomain model is a system of partial differential equations frequently used to model the propagation of electrical potential waves in the heart muscle. It contains a coupled parabolic and elliptic equation, as well as at least one ordinary differential equation to model the ion activity of the myocardium. The nature of this system makes it especially hard to solve. We will consider here several implicit, semi-implicit and explicit time-stepping methods applied to the solution of this model. We will show that they remain stable under certain conditions for the time step Deltat, and we will compare the numerical solutions produced by these methods for two test cases: one in 1D, the propagation of a potential wave across the domain, and another in 2D, the formation of a spiral wave. We recommend using either the Crank-Nicolson-Adams-Brashforth method or the second order SBDF method. These semi-implicit methods produce a good numerical solution, unlike, the explicit methods, their stability does not depend on how fine the spatial mesh is, and unlike the implicit methods, they do not require the resolution of a system of nonlinear equations.
May I long experience the joy of healing: professional and personal wellbeing among physicians from a Canadian province
Creators: name: Lovell, Brenda L
name: Lee, Raymond T
name: Frank, Erica
Publisher: name: BioMed Central
Year: 2015

description: Background: The development of best practices to promote physician wellbeing at the individual and organisational levels is receiving increased attention. Few studies have documented how physicians perceive their wellbeing in these contexts. The purpose of this qualitative study is to identify and discuss the reported factors that hinder wellbeing, as well as the reported factors that would promote wellbeing among physicians. Methods There were 165 physicians from a province of Canada who wrote their open-ended responses to two questions, as part of a larger self-report questionnaire. The questions asked what causes them stress, and what interventions should be implemented at organisational/institutional levels. The largest specialty was family medicine, followed by internal medicine, and surgical disciplines, with 58% of participants male. A general inductive approach was used to analyze the data and themes and sub-themes were discovered using the socio-ecological model as the framework. Results Reponses were both personal and professional which resulted in the emergence of four major themes to reflect this diversity. These themes were external constraints on the practice of medicine, issues at the professional/institutional levels, issues at the individual practice level, and work/life balance. The work/life balance theme received the highest number of responses followed by external constraints on the practice of medicine. In the major theme of work-life balance, work-life conflict received the most responses, and in the major theme of external constraints on practice of medicine, lack of resources (human and material) and restrictions to autonomy received the most responses. Ideas for interventions in the work/life balance theme were health promotion, and healthy workplace initiatives. In the second largest theme, suggested ideas for interventions were collegiality/professionalism and policy formulation at the health care system. Conclusion Our findings have implications for governance and health policy, health human resources and education. In particular, the socio-ecological framework was a useful framework to analyse physician wellbeing due to its applicability for issues at the structural, organisational, and individual levels. Future research should target interventions at the organisational and institutional levels to address work-life conflict and job dissatisfaction.
The Psychosocial Screen for Cancer (PSSCAN): Further validation and normative data
Creators: name: Linden, Wolfgang
name: Andrea Vodermaier, A
name: McKenzie, Regina
name: Barroetavena, Maria C
name: Yi, Dahyun
name: Doll, Richard
Publisher: name: BioMed Central
Year: 2016

description: Background: We have previously reported on the development of a cancer-specific screening instrument for anxiety and depression (PSSCAN). No information on cut-off scores or their meaning for diagnosis was available when PSSCAN was first described. Needed were additional analyses to recommend empirically justified cut-off scores as well as data norms for healthy adult samples so as to lend meaning to the recommended cut-off scores. Methods: We computed sensitivity/specificity indices based on a sample of 101 cancer patients who had provided PSSCAN data on anxiety and depression and who had completed another standardized instrument with strong psychometrics. Next, we compared mean scores for four samples with known differences in health status, a healthy community sample (n = 561), a sample of patients with a representative mix of cancer subtypes (n = 570), a more severely ill sample of in-patients with cancer (n = 78), and a community sample with a chronic illness other than cancer (n = 85). Results: Sensitivity/specificity analyses revealed that an excellent balance of sensitivity/specificity was achievable with 92%/98% respectively for clinical anxiety and 100% and 86% respectively for clinical depression. Newly diagnosed patients with cancer were no more anxious than healthy community controls but showed elevations in depression scores. Both, patients with chronic illness other than cancer and those with longer-standing cancer diagnoses revealed greater levels of distress than newly diagnosed cancer patients or healthy adult controls. Conclusion: These additional data on criterion validity and community versus patient norms for PSSCAN serve to enhance its utility for clinical practice.
Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1
Creators: name: Parkinson, Pamela F.
name: Kannangara, Timal S.
name: Eadie, Brennan D.
name: Burgess, Braydon L.
name: Wellington, Cheryl L.
name: Christie, Brian R.
Publisher: name: BioMed Central
Year: 2016

description: Background: Cognitive deficits are a hallmark feature of both Down Syndrome (DS) and Alzheimer's Disease (AD). Extra copies of the genes on chromosome 21 may also play an important role in the accelerated onset of AD in DS individuals. Growing evidence suggests an important function for cholesterol in the pathogenesis of AD, particularly in APP metabolism and production of Aβ peptides. The ATP-Binding Cassette-G1 (ABCG1) transporter is located on chromosome 21, and participates in the maintenance of tissue cholesterol homeostasis. Results: To assess the role of ABCG1 in DS-related cognition, we evaluated the cognitive performance of mice selectively over-expressing the ABCG1 gene from its endogenous regulatory signals. Both wild-type and ABCG1 transgenic mice performed equivalently on several behavioral tests, including measures of anxiety, as well as on reference and working memory tasks. No deficits in hippocampal CA1 synaptic plasticity as determined with electrophysiological studies were apparent in mice over-expressing ABCG1. Conclusion: These findings indicate that although ABCG1 may play a role in maintaining cellular or tissue cholesterol homeostasis, it is unlikely that excess ABCG1 expression contributes to the cognitive deficits in DS individuals.
ASSESSMENT OF FOREIGN DIRECT INVESTMENT FINANCING PRACTICE OF PRIVATE COMMERCIALBANKS OF ETHIOPIA
Creators: name: AREGA, TADESSE
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: Banks play a very important role in the economic life of a nation though offering various types of financial services for local and foreign investors particularly, This study assessed the involvement of private banks of Ethiopia in financing FDI practice with problem arising to conduct the research of low saving habit of the society and loan disbursement of loan with collateral issue. With objective of knowing the involvement level of private banks in financing FDI practice specifically government support to attaché investment request, the capacity of private banks, their risk appetite and factors that affects to have high/low involvement. The study cover all private banks FDI financing activity from 2006/7-2016/17 time period. The research use both primary and secondary data with mixed of descriptive data analysis. In order to reach to the final finding, primary data were collected through questionnaire with purposive sampling techniques of selecting 64 sample employees and secondary data is collected from report of different organization. The data obtained from questionnaire and secondary data were analyzed both in qualitative and quantitative ways using percentage, tabulation. With regard to this data the research reach on the final conclusion of low involvement of private banks in financing FDI because of factors like collateral issue, government policy and financial capacity of private banks. Though to minimize this overall effect in private bank participation on investing in FDI practice the government should fully support private banks and banks also develop strategy to develop their capacity through better saving mobilization .
ASSESSMENT ON FACTORS AFFECTING EMPLOYEES' PERFORMANCE IN THE CASE OF DEBRE BIRHAN UNIVERSITY
Creators: name: Samuel, Befekadu
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The study investigated the organizational factors that influence the performance of employees at Debre Birhan Universtiy (DBU). The objectives of the study were: to investigate the relationship and effect of Leadership Styles on Employees' Performance in Debre Birhan University,: to assess the relationship and effect of Working Conditions on Employees' Performance in Debre Birhan University and to examine the relationship and effect of Organizational Commitment on Employees' Performance in staff, Administrative staff and Technical Assistants while purposive sampling was used to select Debre Birhan University. A descriptive survey research design was adopted using both quantitative and qualitative methods. The study targeted 187 respondents and all returned the survey questions, indicating a response rate of 100 per cent. Stratified random sampling technique was used to select Academic the middle and top level Management members. Data analysis involved frequencies, percentages and inferential statistics such as correlations and the coefficient of determination. Findings revealed a positive relationship between Leadership Styles and Employees' Performance; a significant positive relationship between Working Conditions and Employees' Performance; and significant relationship between Organizational Commitment and Employee Performance. It was therefore concluded that Leadership Styles, Working Conditions and Organizational Commitment positively affected the performance of employees at DBU in one way or the other. Finally the researcher recommends that the University Management should build and improve on teamwork and develop the current leadership to maintain the culture; create opportunities for employees to interact with the managers of the University in order to improve on the communication; and encourage employee innovation, increase on their motivation, institute organizational loyalty programs and reward long-serving employees and similar other important recommendations has been given.
Organizational learning flow in a granting council
Creators: name: Hammad, Nouhad El-Eid
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Political Science, Public Administration.
subject: Sociology, Organization Theory.
subject: Sociology, Organizational.

description: This program of research examines the perceptions of the flows of learning in a Canadian granting council during its renewal initiative. This case study will answer the following research questions: How do employees of a granting council perceive the flow of learning during the organization's transformation into a knowledge council? More specifically, how do they perceive the feed-forward flow between the individual and the group, and the feedback flow between the organization and the individual? Based on Crossan, Lane and White's (1999) 41 Framework and on the organizational learning, organizational change and social construction literatures, this qualitative study sheds light on two problematic relationships that may lead to tension at the junctures of the flows between the individual and the group, and the organization and the individual. Face-to-face, semi-structured interviews were conducted with 15 participants, and data was analyzed using Miles and Huberman's (1994) methods for interpretation. The data revealed that those who are heavily involved in the renewal conceptualization retain the learning that occurs during organizational changes. It also suggests that some factors consolidated under the constructs of capabilities/capacities, skills, roles and infrastructure, could be considered as indicators of the flows of learning. The findings confirm that middle management has a fundamental role in amplifying knowledge and in engaging and integrating employees. Preliminary results also show that routines are mostly at the individual and group levels, and that along with hierarchy, do not obstruct the flow of learning as much as is commonly believed. This research contributes to theory by studying the learning component during a renewal exercise, by building on the 41 Framework, by providing empirical data, and by extending research on organizational learning in federal granting agencies. Its implications for practice are that the mechanisms to spread organizational learning need to be taught, and that organizations could be considered as neutral rather than benevolent organisms where power is not malevolent, but residing in a set of relationships that employees have to navigate. The fields of education and management may benefit from the narratives that this research provides regarding the learning needs of knowledge workers. Keywords: Feed-forward and feedback flows of learning; tension; granting councils; organizational learning; organizational change.
The role of ACE2 and its product, angiotensin-(1-7), in a model of early chronic kidney disease
Creators: name: Dilauro, Marc
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.

description: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II to angiotensin- (1-7) (Ang-(1-7)). The role of ACE2 and Ang-(1-7) in the progression of chronic kidney disease (CKD) is unclear. We studied the effects of ACE2 inhibition and Ang-(1-7) in the 5/6 nephrectomy (5/6 Nx) mouse model of CKD and sought to generate kidney-specific ACE2 transgenic mice. We hypothesized that pharmacological inhibition of ACE2 would accelerate kidney injury in 5/6 Nx mice whereas administration of Ang-(1-7) might be renoprotective. Four weeks after 5/6 Nx, kidney cortex ACE2 protein expression and enzymatic activity were decreased, compared to Sham-operated mice. In 5/6 Nx mice, ACE2 inhibition significantly increased urine albumin excretion, an effect reversed by Ang II AT1 receptor antagonism. In contrast, Ang-(1-7) did not affect CKD progression. Finally, using a plasmid vector containing the human ACE2 gene linked to the nephrin promoter, transgenic mice were generated that selectively overexpress human ACE2 in the glomerular podocyte. These data suggest that kidney ACE2 is down-regulated in the 5/6 Nx mouse and that further inhibition of ACE2 increases albuminuria via an AT1 receptor-dependent mechanism. The generation of ACE2 transgenic mice will allow for further delineation of the physiological role of ACE2 in the kidney.
Christina Neder: Lesen in der Volksrepublik China. Eine empirisch- qualitative Studie zu Leseverhalten und Lektürepräferenzen der Pekinger Stadtbevölkerung vor dem Hintergrund der Transformation des chinesischen Buch- und Verlagswesens 1978-1995
Creators: name: Schmidt-Glintzer, Helwig
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: ASIEN: The German Journal on Contemporary Asia, Nr. 79 (2001): ASIEN (April)