cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genome-specific synthetic lethal targeting in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A very recent discovery is that about 15% of lung cancers contain amplification (i.e. extra copies) of the TITF1 gene, a transcription factor driving lung cancer development. Unique to lung cancer cells, TITF1 amplification would seem an ideal therapeutic target; however, targeting transcription factors has proven difficult. Our proposed studies are based on the concept of “synthetic lethality”, where cancer cells with specific genetic lesions (like TITF1 amplification) become particularly vulnerable in associated genes or pathways, providing an “Achilles heel” point of therapeutic attack. The goal of our proposed study is to discover those genes whose inactivation is lethal in combination with TITF1 amplification.

 Our findings will improve our knowledge of the role of TITF1 amplification in lung cancer development, and will provide novel targets for the development of treatments for the 15% of lung cancers carrying TITF1 amplification. As such, the proposed research is directly responsive to TRDRP’s primary research priority of lung cancer.
Anterhynchium (Dirhynchium) flavomarginatum subsp. flavomarginatum flavomarginatum (Smith 1852
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Anterhynchium
Anterhynchium flavomarginatum
Anterhynchium (dirhynchium) flavomarginatum flavomarginatum (smith, 1852)

description: Anterhynchium (Dirhynchium) flavomarginatum flavomarginatum (Smith, 1852)
Material examined. INDIA: Karnataka: Chikkamagaluru, Mudigere, 20.v.2015, 1♀, coll. R. Hamsa.
Distribution. India: * Karnataka, Kerala, Tamil Nadu; Assam, Delhi, Himachal Pradesh, Jammu & Kashmir, Meghalaya, Sikkim, Uttarakhand, West Bengal.— China, Japan, Korea, Laos, Mongolia, Nepal, Pakistan, Vietnam (van der Vecht 1963; Kim 2003; Gusenleitner 2006; Girish Kumar 2013c; Nguyen 2015c)
Remarks. A. coracinum van der Vecht, 1963 sensu Girish Kumar (2013) is a misidentification of A. f. flavomarginatum (Smith), and the record of this species from India and Pakistan belongs to A. f. flavomarginatum (Nguyen 2015c).
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on pages 26-27, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Psephenotettix Torres 1958
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Psephenotettix

description: Psephenotettix Torres, 1958
Type species. Psephenotettix minor Torres, 1958.
Remarks. The genus is endemic to Argentina (Torres 1958c).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 80, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Effectivness of inorganic concrete coating matrices and their self cleaning properties
Creators: name: Amer, Ahmed
Publisher: name: No Publisher Supplied
Year: 2008

description: Concrete Coatings are becoming more popular to protect concrete surfaces for infrastructures. The coating improves the durability of concrete structures. Inorganic concrete coatings are better than organic coatings because they allow the release of vapor pressure. The results presented in this thesis deals with the behavior of the inorganic matrices which are based on silicates. The coating is compatible with concrete, brick and wooden surfaces.The objective of the research presented in this thesis is to evaluate the matrices for workability, ease of application and self cleaning properties. Cracking characteristics were also evaluated using high magnification. The self cleaning properties of the coating matrices were studied using Rohdamine B dye to detect the degradation rate of the organic chemicals that represent the organic pollutants in the atmosphere.Advanced technology such as X-ray photoelectron spectroscopy and Atomic force microscope was used to measure the curing period and its effect on the matrices self cleaning properties. The degradation of the organic chemicals represents a breakthrough in the development of the inorganic matrices because they can be used in manyapplications. Matrix combination that provides workable mix and minimum nano-level cracking are recommended.
The contemporary art of travel: siting public sculpture within the culture of flight
Creators: name: Tinti, Mary M.
Publisher: name: No Publisher Supplied
Year: 2008

description: The Contemporary Art of Travel: Siting Public Sculpture within the Culture of Flight, situates the notable yet little known airport installations of Vito Acconci, Diller + Scofidio, Alice Aycock, and Keith Sonnier in their appropriate artistic, theoretical and social contexts.   Provocative and cutting edge, these recent commissions are exemplary for the ways in which they explore the collisions and cross influences of fine art, architecture, technology, flight and travel with particular sensitivity to the qualities that make the airport a singular contemporary space.  More than mere decoration or distraction, these site-responsive artworks are visual representations of exactly how this unique place (or non-place) and this unique culture might coincide in sculptural form.    Teeming with turbulent paradoxes, airports are uncanny, impersonal, in-between spaces;  spaces in which travelers are forced to relinquish control of their autonomy, privacy, safety, sense of time, connections to the ground and links to the world outside.  Unafraid of such air travel truths, the artists profiled in this dissertation use them as a source of inspiration.  Acconci, Diller + Scofidio, Aycock and Sonnier blend these qualities with their own signature, career long conceptual preoccupations; deliberately, ingeniously enmeshing their installations within the physical and psychological schema of this extraordinary site.  Their works are an unflinching, if not disquieting, testament to all that is possible in this bizarrely charged space and unfortunately, what is all too often untapped and/or underappreciated.  As a result, their collective study allows for an up-dated examination of the power of (non-)place and the emblematic journeys which begin and end at the airport, but it is also a means through which to penetrate the polemics of contemporary public art, to begin to redefine expectations for the genre, and to focus critical consideration where it is long overdue.  After all, contemporary public art plays a vital role in shaping, defining and/or revitalizing our urban spaces, and art for the airport is no different.  Jointly a non-place and a simulacrum of the traditional urban gathering place, the airport represents a unique, timely, important and heretofore unexplored category of art commissions for the public sector.
Bar Interventions to Decrease Young Adult and LGBT Smoking
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project addresses the prevention of tobacco related diseases by developing an intervention to block tobacco industry marketing to young adults (age 18-25). Almost all tobacco prevention efforts concentrate on preventing children and adolescents from experimenting with cigarettes despite the fact that the transition from experimentation to regular smoking and addiction often occurs during young adulthood. The tobacco industry has invested millions of dollars in sophisticated marketing research on young adults. Because of current restrictions on marketing to youth, young adults have become an even more important focus of tobacco marketing efforts, which often emphasize events at “adult only” venues (bars, nightclubs and casinos), which are exempt from these restrictions. We hypothesize that successfully competing with industry promotion in these venues will prevent transitions to regular smoking among young adults, preventing both long term morbidity and mortality from smoking.

 In our previous research, we identified a high risk young adult subculture in San Diego and found a smoking prevalence of 50% in the “Hipster” community, a group focused on the alternative music scene, local artists and designers, and eclectic self expression. We developed a year long pilot social branding intervention to decrease smoking among this group, using social events and social leaders to promote a strong nonsmoking lifestyle. We now propose to extend this intervention for 1 year and to evaluate its longer term effects. This research will also test the feasibility of replicating and evaluating the social branding intervention strategy in the underserved Lesbian/Gay/Bisexual/Transgender (LGBT) population in three additional cities.

 This research addresses TRDRP’s research priority to address smoking in California’s diverse populations, including both young adults and LGBT priority populations. The young adult population is particularly important because cessation by age 30 avoids nearly all the long term health consequences of smoking. The results of this research will improve approaches to young adult targeted messaging both for public health campaigns and for clinical patient counseling to block the transition from experimentation to becoming established addicted smokers.
Three-dimensional finite-deformation multiscale modeling of elasto-viscoplastic open-cell foams in the dynamic regime
Creators: name: Romero, Pedro A.
Publisher: name: No Publisher Supplied
Year: 2008

description: Cellular materials such as metallic and polymeric open-cell foams resemble a labyrinth of interconnected struts surrounded by air-filled voids however a closer inspection reveals a periodicity where a particular unit cell is repeated throughout a lattice inside a matrix of air. Depending on the loading rate and the specifics of the cellular topology and the material properties of the solid phase, the different stages of deformation can involve elasticity, plasticity, fracture, viscoelasticiy, thermoelasticity, strain rate effects, density (microinertia) etc. This dissertation contributes an approach for modeling dynamically loaded open-cell foam materials where the structure is mimicked with the replication of a periodic unit cell composed of a four ligament tetrahedron inside a dual tetrakaidecahedron volume element.  Formulation of the Lagrangian for a representative unit cell comprising an imposed macroscopic deformation and enforcement of the principle of minimum action for dissipative systems results in a relation between the globally applied macroscopic deformation and the motion of the internal unit cell vertex, which uniquely defines the kinematic state of each cell and the effective stress state.  By maintaining the history of local non-affine motion and the global affine deformation, the model is able to capture the microinertial and viscous effects important during dynamic loading of open-cell foams. The micromechanical formulation is used to predict the dynamic compressive uniaxial response of polymeric (visco-elastic) and metallic (elasto-plastic) open-cell foams for different loading rates and structural and material properties gauging the effects of strain rate, viscosity, plasticity and microinertia. The predictions capture the experimentally observed effects namely that as the strain rate increases the foam strength increases and that this effects are more pronounced for more viscous or more massive foams. The micromechanical alone provides the effective foam response in a numerically efficient manner allowing the user to probe a wide range of material properties and cellular dimensions in a short amount of time. However in order to predict the full field, full range response of an open-cell foam specimen, it is necessary to implement the micromechanical model as a constitutive update into implicit and/or explicit nonlinear dynamic finite element analysis FEA schemes.  The FEA simulations clearly capture the experimentally observed signature response with the different stages including the heterogeneous bands of deformation during dynamic compression of cellular materials.
Psephenotettix grandis Torres 1958
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Psephenotettix
Psephenotettix grandis

description: Psephenotettix grandis Torres, 1958
Psephenotettix grandis Torres 1958c: 37 (type material examined).
Type locality. Salta, Argentina.
Remarks. The species is known from Catamarca, Mendoza, Salta, San Juan, and Tucumán Provinces in Argentina (Torres 1958c). We collected examples in Tucumán Province. The species is associated with the Monte and Prepuña floristic provinces (Sanborn et al. 2011a).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 80, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Cigarette Smoke Exposure In Utero: Influence on Neonatal Imm
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoke (CS) exposure may have long term physiological consequences, including an association with decreased lung function and increased airway hyperresponsiveness. In utero CS exposure and its influence on later outcomes, including immune responses, has not been well described. Our objective is to analyze the effect of CS exposure on neonatal allergic responses. Asthma is the most common chronic disease of childhood, with increasing incidence and severity. Due to the current nascent understanding of asthma pathogenesis, we propose that systems biology approaches are ideally suited to investigate immune responses that may be initiated in utero, modified by CS exposure, and potentially predisposed to clinical asthma. Thus, by using systems biology approaches, we will identify and characterize modulated genes and activated signal transduction pathways differentially regulated in children following in utero cigarette smoke exposure, a form of secondhand smoke.

 Our preliminary data and published work shows that in utero CS exposure is associated with significantly increased human cord blood mononuclear cell (CBMC) allergic responses. We have previously reported an association of increased CBMC allergic responses with subsequent childhood wheezing. We plan to identify the pathways crucial in modifying allergic immune responses. To attain this goal, we build upon our analyses of immune and physiological outcomes and perform systems biology investigations. Our hypothesis is that in utero CS exposure exacerbates perinatal allergic immune responses which may predispose to childhood asthma. Aim 1 will determine the fetal cord blood neonatal immune responses and genes influenced by in utero CS exposure. Based on differential gene expression profiles, Aim 2 will identify candidate genes in activated signal transduction pathways induced in fetal cord blood by in utero smoke exposure. Aim 3 will determine whether candidate genes in activated immune pathways modulated by CS exposure are associated with enhanced childhood allergic responses.
Psephenotettix minor Torres 1958
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Psephenotettix
Psephenotettix minor

description: Psephenotettix minor Torres, 1958
Psephenotettix minor Torres 1958c: 35 (type material examined).
Type locality. Puna Jujeña, Jujuy Province, Argentina.
Remarks. The species is known only from Jujuy Province in Argentina (Torres 1958c) which is where we collected our specimens. The species is associated with the Prepuña floristic provinces (Sanborn et al. 2011a).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on pages 80-81, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Antodynerus flavescens subsp. flavescens flavescens (Fabricius 1775
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Antodynerus
Antodynerus flavescens
Antodynerus flavescens flavescens (fabricius, 1775)

description: Antodynerus flavescens flavescens (Fabricius, 1775)
Material examined. No specimens examined.
Distribution. India: Andhra Pradesh, Karnataka [Bengaluru], Kerala [Kochi], Puducherry, Tamil Nadu; Assam, Bihar, Chhattisgarh, Delhi, Goa, Gujarat, Maharashtra [Mumbai], Manipur, Odisha [Barkuda, Chilka Lake], Uttarakhand [Dehra Dun], Uttar Pradesh [Allahabad], West Bengal.— Bangladesh (Girish Kumar & Carpenter 2013; Girish Kumar & Sharma 2015b).
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 27, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Quantitative Proteomics of Oral Precancer Progression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is a deadly disease affecting over 300,000 people worldwide annually. OSCC occurs twice as often in the black population as in whites. Racial disparities also exist in 5-year relative survival rates, with whites having the highest rates and black males the lowest rates. Despite the high morbidity rate of human oral cancer, the molecular events leading to the progression of oral precancer to cancer are still elusive. Currently there is no molecular and clinical parameter that can predict the malignant progression of oral precancers. This proposal aims to determine the quantitative changes in protein expression that are associated with oral precancer progression using emerging proteomic technologies. First we will demonstrate a new proteomics approach for studying oral cancer. This approach is based on quantitative analysis of microdissected FFPE (formalin-fixed paraffin-embedded) tissues using stable isotope labeling (iTRAQ) and monolithic liquid chromatography-tandem mass spectrometry (Aim 1). Next, we will apply the established methodology to analysis of oral premalignancies in vivo. Quantitative proteomic analysis of progressing and non-progressing oral cancers from minority, under-researched patient populations will be performed to identify protein biomarkers for oral precancer progression (Aim 2). The hypothesis to be tested is that there are distinct protein alterations between progressing and nonprogressing oral precancers, which may predict the malignancy-converting potential of oral precancer lesions. Discovery of the proteomic biomarkers for oral precancer progression can be translate into prediction models for early disease detection and may contribute to understanding the molecular mechanism of oral carcinogenesis. Ultimately we aim to understand the synergistic role and related signal pathways of the discovered targets in oral carcinogenesis. Since our study design is specifically targeted at the under-researched patient populations, the research findings may facilitate the early detection/screening of oral cancer in these populations and therefore contribute to reducing racial disparities in oral cancer morbidity and mortality.
Towards scientific manufacturing: the effects of shear rate, strain, and composition on the properties of blends and tablets
Creators: name: Llusá, Marcos
Publisher: name: No Publisher Supplied
Year: 2008

description: This dissertation aims at understanding the effects of formulation (type of excipient, APAP grade, lubricant concentration) and processing conditions (shear rate and strain) on the following properties of pharmaceutical blends and tablets: 1.Degree of Active Pharmaceutical Ingredient (API) agglomeration and homogeneity. 2.Density, flowability, and hydrophobicity of lubricated formulations.3.Tablet hardness. Another aim is to develop a method to assess the API de-agglomeration in blenders, when only a small fraction of the blend is sampled.The blend properties examined are those that impact on the quality of the product: blend density determines the amount of powder that fills the tablet dies, blend hydrophobicity determines the dissolution properties of tablets, powders, or capsules, and API agglomeration determines the probability of having out-of-specification products.The experimental method uses a shear cell where shear rate and strain can be controlled. The different blend properties are measured using suitable analytical techniques.For the assessment of API de-agglomeration in blenders, a numerical method is developed to design sampling protocols that detect and characterize agglomerates with a degree of statistical confidence.The results show that: 1.The degree of API agglomeration decreases as a function of strain, and independently of shear rate. A coarser API presents a significantly smaller degree of agglomeration than a finer API. De-agglomeration proceeds at very similar rates in different excipients. 2.Blend hydrophobicity increases steadily as a function of strain and lubricant concentration. Larger shear rates increase hydrophobicity even further. Tapped density of lubricated blends increases as a function of strain until reaching a maximum value, independently of shear rate. The flowability of lubricated blends is enhanced but independently of strain and shear rate they have been exposed to. 3.The tablet crushing hardness is a function of the strain applied to lubricated blends and independent of the shear rate.The statistical method used to detect and characterize API agglomerates in blenders yields concentration profiles that compare very well to the experimental concentration profile. This procedure validates the parameters that describe the agglomerate population (with a normal distribution of sizes) in a blend.
Babras Jacobi 1907
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Babras

description: Babras Jacobi, 1907
Type species. Babras sonorivox Jacobi, 1907.
Remarks. The genus is endemic to Argentina (Metcalf 1963c; Duffels and van der Laan 1985; Sanborn 2013).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 81, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
RESEÑA CUANTITATIVA DE ARTÍCULOS SOBRE CÓMIC Y EDUCACIÓN EN IBEROAMÉRICA
Creators: name: Grande de Prado, Mario
Publisher: name: Zenodo
Year: 2024

description: PREPRINT (2020).  TRADUCCIÓN AL ESPAÑOL (2024). REALIZADA CON FINES EDUCATIVOS.

This is an original manuscript of an article published by Taylor & Francis in Journal of Graphic Novels and Comics on 2022, available at: https://doi.org/10.1080/21504857.2021.1898428.

Versión final (en inglés): Grande-de-Prado,M  (2022): Quantitative review of articles about comic & education in Ibero-America, Journal of Graphic Novels and Comics, 13 https://doi.org/10.1080/21504857.2021.1898428
Ports of slavery, ports of freedom: how slaves used northern seaports' maritime industry to escape and create trans-atlantic identities, 1713-1783
Creators: name: Foy, Charles R.
Publisher: name: No Publisher Supplied
Year: 2008

description: This dissertation examines and reconstructs the lives of fugitive slaves who used the maritime industries in New York, Philadelphia and Newport to achieve freedom. It focuses on slaves during the period between 1713, the end of Queen Anne’s War, and 1783, the end of the American Revolution. While the study’s primary focus is on slavery in three port cities, it employs a broad geographic approach to consider how enslaved individuals in rural areas surrounding New York, Philadelphia and Newport, as well as slaves in more distant regions, used the maritime industry in northern port cities to escape slavery. Maritime work provided unique opportunities for fugitive slaves to exploit conflicts among whites to create relative autonomy and obtain freedom. The work makes five significant contributions to the field of early American history. First, the dissertation demonstrates that the key characteristics of slavery in northern ports were slaves’ mobility, the diversity of the labor they performed, and their strong connection to the Atlantic maritime community. Second, it illustrates that the maritime industry in northern port cities of British North America provided slaves viable means to obtain freedom. Third, it describes the significant eighteenth century black maritime community in port cities of British North America and the larger Black Atlantic. Its fourth contribution is to the field of Atlantic history. The work depicts the interconnections among Atlantic ports in the eighteenth century. It also globalizes the struggle of enslaved peoples by placing their flight to freedom within a larger Atlantic context. The last, but far from least, contribution of this study is that it personalizes the stories of enslaved individuals, many of whose lives have remained largely unknown.
Antodynerus limbatus
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Antodynerus
Antodynerus limbatus

description: Antodynerus limbatus (de Saussure, 1852)
Material examined. INDIA: Karnataka: Bangalore, GKVK, 930 m, 13°04' N 77°34' E, 1. ii.2014, 1 ♂, coll. A. Pannure; Dakshina Kannada, Moodabidri, 80 m, 13°06' N 75°06' E, 25. vii.2015, 2 ♀, coll. C. Prashantha. Gulberga, 454 m, 7. ix.1980, 1 ♀, coll. A.R.V Kumar. Koppal, Munirabad, 14.10.2013, 1♂, coll. S. Najeer. Mysore, Chinnamballi, 716 m, 12°05' N 76°49' E, 30. vii.2014, 1 ♀, coll. C. Prashantha. Kerala: Padannakkad, 29. ix.2011, 1 ♀, 1Ƌ, coll. T.V. Aswathy; 14 m, 12°15' N 75°07' E, 14. viii.2014, 1 Ƌ, coll. C. Prashantha. Ernakulam, Perumbavoor, 33 m, 26.x, 27. x.2011, 1 ♀, 2♂, coll. T.V. Aswathy.
Distribution. India: * Karnataka, Kerala [Palakkad (Malampuzha)]; Arunachal Pradesh, Assam, Delhi, * Haryana [Panchkula (Morni hills)], Himachal Pradesh, Jammu & Kashmir, Manipur, Maharastra [Pune?], Meghalaya [Khasia Hills, Garo Hills, Baghmara], Mizoram, Nagaland, Rajasthan [Udaipur], Sikkim [Dentam, Paykong, Melli Bazar, Tashiding], Tripura, Uttarakhand [Mussoorie, Yamuna river valley near Juido village], West Bengal [Barrackpore, Darjeeling].— China [Tibet], Laos, Myanmar, Nepal, Pakistan, Thailand (Gusenleitner 2006; Girish Kumar & Carpenter 2013; Girish Kumar & Sharma 2014).
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 27, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Autophagy and cell fate in K-Ras mutant lung cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer death, both in the United States and worldwide. Unfortunately, this disease is largely preventable because the majority of cases are attributable to smoking. Nonetheless, because of the extensive lethality currently associated with smoking-related lung cancers, we urgently require new therapeutic approaches to treat smokers who develop these tumors. About 85% of all lung cancers are a type of tumor called non-small cell lung carcinoma (NSCLC). Importantly, the most common abnormality found in NSCLC involves a molecule called KRas. Extensive research indicates that chemicals in cigarette smoke commonly cause specific mutations in the KRAS gene, turning it into a cancer-promoting molecule (called an oncogene). In fact, KRas mutations, which are present in up to 20% of all patients with NSCLC, are almost exclusively found in smokers.

 Most importantly, smokers who develop lung cancer with KRas mutations invariably have a very bad prognosis, because they do not respond to standard chemotherapy or to targeted therapies more beneficial for non-smokers with lung cancer. Thus, new processes and pathways capable of killing or suppressing the growth of lung cancer cells with KRas mutations must be identified; such discoveries will potentially benefit a large number of large patients with these common and lethal smoking-related abnormalities in KRas.

 We believe that we have identified a cellular process, called autophagy, which can be used to precisely target KRas mutant lung cancer cells. During autophagy, a cell digests and recycles its own contents (i.e., literally “eats itself”), which provides cancer cells with the resources and energy they need to effectively to respond to acute stress—during starvation or even chemotherapy, for instance. Our preliminary work indicates that cancer cells expressing mutated KRas exhibit very high levels of autophagy. We hypothesize that the increased autophagy in KRas mutant cells contributes to their well-being, and to the detriment of the patient. In support of this model, when we inhibit autophagy in mutant KRas-expressing cells, they no longer behave like cancer cells; indeed, they completely lack the ability to grow and survive in adverse conditions. Based on this data, we believe that autophagy inhibition can be exploited to kill or suppress the growth of lung cancer cells with smoking-related KRas mutations. Through this TRDRP Exploratory Award proposal, we will obtain the preliminary data to prove this novel concept. Our proposed studies will lay the foundation for future work to translate these findings and manipulate autophagy to treat the large number of smokers who develop lung cancers with invariably lethal KRas mutations.
Relationship between self and physical body: an examination of the phenomenon of disconnect
Creators: name: Broccoli, Tara Lynn
Publisher: name: No Publisher Supplied
Year: 2008

description: Different levels of connectedness characterize the relationship between self and body between individuals as well as across situations.  Specifically, the potential of the physical body to be regarded as an object introduces the possibility of trait and state body disconnect.  In this dissertation, body disconnect is defined as the psychological separation of the self from the physical body.  Three studies explored the experience of disconnect in women and men.  The first study validated a measure of body disconnect and examined the prevalence of the phenomenon in women and men.  Results were generally consistent with hypotheses: the body disconnect measure demonstrated convergent and discriminant validity.  However, women did not evidence greater trait levels of body disconnect than men.  The second study tested the relative impact of appearance and competence threats on women and men’s experience of state disconnect.  Results indicated that competence threats caused women and men to psychologically disconnect from their bodies.  Moreover, decreased appearance evaluation in response to competence threat mediated the relationship between threat and body disconnect.  The third study tested a model of body disconnect and physical health correlates (i.e., fitness and health orientations, performance of health behavior) of body disconnect.  Results supported the proposed model such that body disconnect predicted physical activity and fruit and vegetable consumption.   Increased levels of body disconnect were associated with less performance of health behavior.  Moreover, body disconnect predicted fitness and health orientations, which mediated the relationships between body disconnect and physical activity and fruit and vegetable consumption, respectively.  Together, the findings of the three studies suggest that men and women experience body disconnect and disconnect from their bodies when their appearances are threatened.  Additionally, body disconnect is associated with health behavior.  Discussion considers the active or passive nature of body disconnect as well as adaptive and maladaptive correlates.  Implications of the research and intervention efforts to foster connectedness are also discussed.
Babras sonorivox Jacobi 1907
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Babras
Babras sonorivox

description: Babras sonorivox Jacobi, 1907
Babras sonorivox Jacobi 1907b: 206 (type material examined).
Type locality. Santiago del Estero, Argentina. Torres (1959) added Suncho Corral for a more specific type locality.
Remarks. The species was reported from Santiago del Estero Province (Torres 1959), and we reported the species from La Rioja Province without location (Sanborn et al. 2004). We collected the species in La Rioja and Santiago del Estero Provinces. It is associated with the Monte floristic province (Sanborn et al. 2011a).
New provincial records. La Rioja, Patquia, 5-I-1987, Al Sanborn Coll. (one male, MSHC, one male, AFSC); La Rioja, Patquia, 5-I-1987, F. Noriega Coll. (one male, MSHC); La Rioja, Patquia, 5-I-1987, M.S. & J.E. Heath Coll. (one male, MSHC); La Rioja, Dto. Independencia, Patquia, 21-I-1988, M.S. & J.E. Heath, Al Sanborn & F. Noriega coll. (one male, one female, MSHC, one male, AFSC); Prov. La Rioja, Patquia, 8-I-1992, A. Sanborn Coll. (one male, AFSC).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 81, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Differentiation of mouse embryonic stem cells along a hepatocyte lineage
Creators: name: Novik, Eric I.
Publisher: name: No Publisher Supplied
Year: 2007

description: The development of implantable engineered liver tissue constructs, ex vivo hepatocyte based therapeutic devices and drug discovery studies are limited by an inadequate hepatocyte cell source. Embryonic stem (ES) cells, characterized by their self-renewing and multi-lineage differentiating capabilities, represent a promising mature cell source required for these applications. Previous research has utilized embryoid body (EB) formation in both guided, through extracellular matrix and growth factor supplementation, and unguided, or spontaneous, differentiation to generate hepatocyte like cells. However, these characterizations have been limited to only one or several lineage specific protein or gene expression patterns. In addition, there have been few reports of long term propagation or characterization of long term function for ES cell derived hepatocyte precursors. In this thesis, we have implemented a platform for the long term propagation and augmentation of functional hepatocytes generated from murine ES cell sources. We first utilize a controlled, reproducible, EB mediated differentiation system to characterize efficiency of hepatocyte lineage commitment in four parallel culture configurations. These studies have shown that, EB mediated stem cell differentiation spontaneously yield populations of hepatocyte lineage cells expressing mature hepatocyte markers such as albumin (ALB) and Cytokeratin 18 (CK-18). We then used secondary culture configurations to study the effects of collagen sandwich culture and Oncostatin-M (OSM) or S-nitroso-N-acetylpenicillamine (SNAP) supplementation of EB derived hepatocyte-lineage cell function. The results of these studies suggest that SNAP, independent of the collagen supplementation, maintains the highest levels of ALB expression, however mature liver specific CK-18 is only expressed in the presence of both gel sandwich culture supplemented with SNAP. In addition, albumin secretion and Cytochrome P450 detoxification studies indicated that this condition was the best for the augmentation of hepatocyte-like function. Maintenance and augmentation of hepatocyte-like cells isolated from heterogeneous EB cell populations will be a critical step in generating large numbers of functional differentiated cells for therapeutic use.
Antodynerus punctatipennis
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Antodynerus
Antodynerus punctatipennis

description: Antodynerus punctatipennis (de Saussure, 1853)
Material examined. INDIA: Karnataka: Bangalore, GKVK, 27.i.1981, 1♂, coll. SPR. Dakshina Kannada, Moodabidri, 80 m, 13°06' N 75°06' E, 25.vii.2015, 1♀, 2♂, coll. C. Prashantha. Udupi, Brahmavar, ARS, 24 m, 13°43' N 74°74' E, 12.iv.1984, 1♀, coll. B. Mallik; 11.v.1984, 1Ƌ, coll. A.R.V. Kumar. Kerala: Padannakkad, 13 m, 12°25' N 75°11' E, 22.v.2014, 2♂, coll. H.M. Yeshwanth.
Distribution. India: Karnataka [Dakshina Kannada (Sullia), Kodagu (Madikeri)], Kerala [Palakkad (Malampuzha)]; Delhi, Maharashtra [Mumbai], Sikkim, Uttarakhand [Mussoorie, Yamuna river valley near Juido village], Uttar Pradesh [Allahabad] (Gusenleitner 2006; Girish Kumar & Carpenter 2013).
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 28, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Calliopsida Torres 1958
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Calliopsida

description: Calliopsida Torres, 1958
Type species. Tettigades cinnabarina Berg, 1879.
Remarks. The genus was recorded from Argentina and Chile (Metcalf 1963c; Duffels & van der Laan 1985; Sanborn 2013).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 81, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Video multicast over wireless local area networks
Creators: name: Makharia, Shivesh
Publisher: name: No Publisher Supplied
Year: 2007

description: Video multicast services over wireless media are expected to grow in importance over the next few years. Multicasting over wireless networks is complicated by the fact that wireless links are error-prone and time varying. In multicast scenarios using the 802.11 wireless LAN protocol, multiple receivers experience widely varying channel conditions and the link layer protocol does not retransmit erroneous or lost packets, potentially resulting in poor video quality. Therefore, it is a key requirement to support quality of service for all the receivers of the multicast video in the desired coverage area while efficiently utilizing the available wireless LAN resources.In this thesis, we investigate some of the aspects of reliable video multicast over WLANs. We design, implement and evaluate multi-group hybrid ARQ (MHARQ), a new and improved adaptive system for reliable video multicast. MHARQ combines the advantages of receiver-driven staggered FEC and hybrid ARQ schemes to compensate the large dynamic range of WLAN channels and to achieve high reliability, scalability and wireless bandwidth efficiency for video multicast. The FEC packets generated by a cross-packet FEC code are divided into multiple streams according to the pre-configured overhead and are transmitted in different multiple IP multicast groups. Certain FEC streams are delayed from the original video stream. The receivers dynamically join/leave the FEC multicast groups based on the channel conditions. For efficient utilization of WLAN bandwidth, FEC data for a multicast group would not be transmitted by the APs in wireless networks if no receiver joins this group. The time shift between the video stream and the FEC streams introduces temporal diversity and compensates for the client join delay and handoff interruption. In addition, when delayed FEC packets are not enough to recover the lost packets, the receivers can send a hybrid ARQ request to the video server. We design a channel estimation algorithm for a receiver to dynamically determine the delayed FEC multicast groups to join and/or send ARQ NACK to request for retransmission. Using the ORBIT radio grid testbed, we have investigated the performance of the proposed MHARQ system with various numbers of users per AP and different numbers of APs per video server. It is demonstrated via real system implementation on ORBIT that MHARQ improves wireless bandwidth efficiency and scalability for reliable video multicast, compared with existing reliable multicast schemes. The experience and insight obtained from implementation are discussed as well.
SUSTAINABLE INVESTING UNVEILED: THE ROLE OF BOND RATINGS IN GUIDING GREEN BOND INVESTMENTS
Creators: name: T. LAVANYA
name: Dr. SADASIVAM RANI
Publisher: name: Zenodo
Year: 2023
Subjects: Sustainable Investing, Environmental Projects, Investment Risk, Capital Mobilization, Sustainable Finance.

description: Abstract

The increasing urgency to address climate change has propelled sustainable investing into the spotlight, with green bonds emerging as a pivotal instrument for mobilizing the capital required for environmental projects. This study delves into the critical role that bond ratings play in guiding investments in green bonds, shedding light on how these ratings influence investor confidence and the allocation of funds towards sustainable initiatives. By employing a mixed-methods approach, combining quantitative analysis of green bond performance with qualitative interviews from industry experts, this research offers a comprehensive overview of the interplay between bond ratings and green bond investments. The findings suggest that higher bond ratings, often indicative of lower risk and better sustainability credentials, significantly impact the attractiveness of green bonds to investors. Additionally, the study examines the evolution of rating criteria to encompass environmental, social, and governance (ESG) factors, highlighting the shift towards more holistic assessments of investment risk and potential. This research contributes to the broader discourse on sustainable finance by providing insights into the mechanisms through which bond ratings can facilitate more informed and impactful green bond investments.
Just policies? a multiple case study of state environmental justice policies
Creators: name: Baptista, Ana
Publisher: name: No Publisher Supplied
Year: 2008

description: Over the last two decades, more than thirty states have implemented explicit environmental justice policies and programs in response to a plethora of empirical research and grassroots advocacy focused on environmental burdens in low income and minority communities throughout the country.  Despite this increasing trend towards state institutionalization of environmental justice issues, there is little research examining the relevance, effectiveness and general impact of state government responses on environmental justice.  Does this trend to implement state level policies make an impact in disadvantaged communities?  Furthermore, how relevant are these state policies in terms of addressing the complex nature of environmental injustice? Using in depth and multiple case studies, the effectiveness and relevance of some of the leading state environmental justice policies in the nation are examined including New Jersey, New York, California, Massachusetts, and Connecticut. The in depth case studies of New Jersey's policies reveal how the state's institutionalization of environmental justice drives the regionalization of the environmental justice movement and their articulation of broader social justice goals. The New Jersey cases also support the findings of the multiple state studies, which reveal a distinct process of implementation of environmental justice policies. In this implementation model, states begin by recognizing environmental injustice as a distributive problem in environmental management terms and then turn to largely symbolic, procedural mechanisms to respond to these problems without addressing the underlying structural inequalities that fuel environmental injustices. The case studies reveal that environmental injustice is tied to deeper forms of structural inequality that require more profound shifts in the way the state addresses economic and environmental problems in poor, minority communities. The existing state policies are inadequate to meet this task and will require recognition of and commitment to addressing the multi-dimensional nature of environmental injustice as a distributive, procedural and structural issue in order to effectively implement change.
An atypical nicotine receptor: target for anti-angiogenics?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: According to the U.S. National Institute of Health, cigarette smoking is a major cause of heart disease, tumor and visual loss. Tobacco smoke contains about 4000 different chemicals. One of these chemicals is nicotine. We have discovered that tobacco smoke can cause abnormal vessel formation, because of the nicotine within it. Nicotine hijacks the body’s mechanism for growing new blood vessels (the growth of new blood vessels is a normal process required for wound healing). Nicotine does so by activating specific receptors on blood vessels. These receptors (nicotinic acetylcholine receptors, or nAChRs) are normally stimulated by the body’s own molecules, most particularly acetylcholine. Nicotine over-stimulates the nAChRs to cause abnormal vessel growth. Abnormal vessel growth plays a role in the growth of tumors and vessel plaque. Abnormal vessel growth in the back of the eye (age-related maculopathy or AMD) is the major cause of blindness in this country. The major preventable risk factor for tumor, plaque, and AMD is tobacco.

 We have shown that certain drugs, which block the nAChR, can reduce abnormal vessel growth in animal models of tumor, plaque, and AMD. Indeed, based upon our work, the FDA has now approved a study in people with AMD to determine if a drug that blocks the nAChR can prevent visual deterioration (by blocking abnormal vessel formation in the retina).

 However, we still know very little about how the nAChR regulates the cells in blood vessels. This study is directed towards understanding how stimulation of the nAChR activates blood vessels to grow. Our work has already resulted in a possible new drug for a tobacco-related disease. The work that we now propose is intended to provide new and useful knowledge about how the nAChRs control other channels expressed in cells that make up the blood vessel. The study is driven by our intent to refine a new therapeutic strategy for tobacco-related disease.