cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: 01_1900
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Hypoxia-guided adaptive radiation dose escalation in head and neck carcinoma: A planning study
Creators: name: Servagi-Vernat, Stéphanie
name: Differding, Sarah
name: Sterpin, Edmond
name: Francois-Xavier Hanin
name: Labar, Daniel
name: Bol, Anne
name: Lee, John A.
name: Grégoire, Vincent
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Cancer
subject: Science Policy

description: Objective. To evaluate from a planning point of view the dose distribution of adaptive radiation dose escalation in head and neck squamous cell carcinoma (HNSCC) using 18F-Fluoroazomycin arabinoside (FAZA) positron emission tomography/computed tomography (PET-CT). Material/methods. Twelve patients with locally advanced HNSCC underwent three FAZA PET-CT before treatment, after 7 fractions and after 17 fractions of a carboplatin-5FU chemo-radiotherapy regimen (70 Gy in 2 Gy per fraction over 7 weeks). The dose constraints were that every hypoxic voxel delineated before and during treatment (newborn hypoxic voxels) should receive a total dose of 86 Gy. A median dose of 2.47 Gy per fraction was prescribed on the hypoxic PTV defined on the pre-treatment FAZA PET-CT; a median dose of 2.57 Gy per fraction was prescribed on the newborn voxels identified on the first per-treatment FAZA PET-CT; a median dose of 2.89 Gy per fraction was prescribed on the newborn voxels identified on the second per-treatment FAZA PET-CT. Results. Ten of 12 patients had hypoxic volumes. Six of 10 patients completed all the FAZA PET-CT during radiotherapy. For the hypoxic PTVs, the average D50% matched the prescribed dose within 2% and the homogeneity indices reached 0.10 and 0.12 for the nodal PTV 86 Gy and the primary PTV 86 Gy, respectively. Compared to a homogeneous 70 Gy mean dose to the PTVs, the dose escalation up to 86 Gy to the hypoxic volumes did not typically modify the dose metrics on the surrounding normal tissues. Conclusion. From a planning point of view, FAZA-PET-guided dose adaptive escalation is feasible without substantial dose increase to normal tissues above tolerance limits. Clinical prospective studies, however, need to be performed to validate hypoxia-guided adaptive radiation dose escalation in head and neck carcinoma.
Additional file 1 of Disparities in expected driving time to opioid treatment and treatment completion: findings from an exploratory study
Creators: name: Alibrahim, Abdullah
name: Marsh, Jeanne C.
name: Amaro, Hortensia
name: Kong, Yinfei
name: Khachikian, Tenie
name: Guerrero, Erick
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1.
Additional file 1: of Cloning and characterization of enoate reductase with high β-ionone to dihydro-β-ionone bioconversion productivity
Creators: name: Zhang, Xuesong
name: Liao, Shiyong
name: Cao, Fuliang
name: Zhao, Linguo
name: Pei, Jianjun
name: Tang, Feng
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Sequence of DBR1, DBR2, BacOYE1, and CL2687.Contig2_ALL. (DOCX 24 kb)
Additional file 1 of Clinicophysiological and hematobiochemical effect of dexmedetomidine or diazepam with ketamine and propofol in total intravenous anesthesia in goats
Creators: name: Ragab, G.
name: Hassan, S. E.
name: Fathi, M. Z.
name: Hagag, U.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. Normal range values for different physiological and hematobiochemical parameters assessed in this study.
Additional file 5: of Transcriptome sequencing and analysis during seed growth and development in Euryale ferox Salisb
Creators: name: Liu, Xian
name: He, Zhen
name: Yin, Yulai
name: Xu, Xu
name: Wu, Weiwen
name: Li, Liangjun
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Tables S3. Differentially expressed genes (DEGs) identified in pairwise comparisons of developmental stages in E. ferox seeds. (DOCX 15 kb)
Impact of hand-foot skin reaction on treatment outcome in patients receiving capecitabine plus erlotinib for advanced pancreatic cancer: A subgroup analysis from AIO-PK0104
Creators: name: Kruger, Stephan
name: Boeck, Stefan
name: Heinemann, Volker
name: Ruediger P. Laubender
name: Vehling-Kaiser, Ursula
name: Waldschmidt, Dirk
name: Kettner, Erika
name: Märten, Angela
name: Winkelmann, Cornelia
name: Klein, Stefan
name: Kojouharoff, Georgi
name: Gauler, Thomas C.
name: Weikersthal, Ludwig Fischer Von
name: Clemens, Michael R.
name: Geissler, Michael
name: Greten, Tim F.
name: Hegewisch-Becker, Susanna
name: Modest, Dominik P.
name: Stintzing, Sebastian
name: Haas, Michael
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Background. Drug-induced skin toxicity may correlate with treatment efficacy in cancer patients receiving chemotherapy or biological agents. The correlation of the capecitabine-associated hand-foot skin reaction (HFS) on outcome parameters in pancreatic cancer (PC) has not yet been investigated. Methods. Within the multicentre phase III AIO-PK0104 trial, patients with confirmed advanced PC were randomly assigned to first-line treatment with either capecitabine plus erlotinib (150 mg/day, arm A) or gemcitabine plus erlotinib (150 mg/day, arm B). A cross-over to either gemcitabine (arm A) or capecitabine (arm B) was performed after failure of the first-line regimen. Data on skin toxicity were correlated with efficacy study endpoints using uni- and multivariate analyses. To control for guarantee-time bias (GTB), we focused on subgroup analyses of patients who had completed two and three or more treatment cycles. Results. Of 281 randomised patients, skin toxicity data were available for 255 patients. Median time to capecitabine-attributed HFS was two cycles, 36 of 47 (77%) HFS events had been observed by the end of treatment cycle three. Considering HFS during first-line treatment in 101 patients treated with capecitabine for at least two cycles within the capecitabine plus erlotinib arm, time to treatment failure after first- and second-line therapy (TTF2) and overall survival (OS) both were significantly prolonged for the 44 patients (44%) with HFS compared to 57 patients without HFS (56%) (TTF2: 7.8 vs. 3.8 months, HR 0.50, p = 0.001; OS: 10.4 vs. 5.9 months, HR 0.55, p = 0.005). A subgroup analysis of 70 patients on treatment with capecitabine for at least three cycles showed similar results (TTF2: 8.3 vs. 4.4 months, HR 0.53, p = 0.010; OS: 10.4 vs. 6.7 months, HR 0.62, p = 0.056). Conclusion. The present subgroup analysis from AIO-PK0104 suggests that HFS may serve as an independent clinical predictor for treatment outcome in capecitabine-treated patients with advanced PC.
Additional file 1 of The local burden of disease during the first wave of the COVID-19 epidemic in England: estimation using different data sources from changing surveillance practices
Creators: name: Nightingale, Emily S.
name: Abbott, Sam
name: Russell, Timothy W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1. Supplementary Materials.
Critically ill cancer patients with influenza (H1N1) infection in the intensive care unit in Greece
Creators: name: Poulikakos, Panagiotis
name: Tsispara, Anastasia
name: Vartzeli, Panagiota
name: Zakka, Maria
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Critically ill cancer patients with influenza (H1N1) infection in the intensive care unit in Greece
Why is intravenous chemotherapy cancelled and how often. Could it be prevented? A prospective analysis of all planned and given intravenous anti-tumor treatments at the Department of Oncology, Karolinska University Hospital, Stockholm during one month
Creators: name: Fuentes, Stina
name: Jan-Erik Frödin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background. Chemotherapy and targeted drugs are important tools in the treatment of malignant diseases. A number of the planned treatments are cancelled late which is a great challenge for the clinic to minimize in order to prevent the risk for misused resources. The aim of this study was to analyze the frequency and reasons for late (<48 hours) cancellations and also to get an overview of all intravenous medical anti-cancer treatment at the clinic. Material and methods. During four weeks in October 2010 all patients with intravenously administered chemotherapy and/or targeted drugs were registered at the Department of Oncology, Karolinska University Hospital. The survey comprehends the vast majority of all such treatment for solid tumors in adult patients in the Stockholm region with two million inhabitants. All bookings and late cancellations including their reasons were recorded. Diagnoses, treatment indication, line of treatment and survival, in particular short term survival, were analyzed. Results. Almost 3000 bookings for 1460 patients were included and 13% were cancelled late. Patient detoriation was the dominating cause for late cancellation in patients with palliative treatment (59%), while hematological toxicity was most common in the adjuvant group (42%). The most common treatment indication was palliative (62%). Of the palliative treatments, 95% where given in the first to third treatment line. Breast cancer (31.9%) and colorectal cancer (29.9%) were the two most common diagnoses. Seventy-one patients (4.9%) died within two months after the treatment. Conclusion. A more careful selection and monitoring of the patients might reduce the number of late cancellations due to patient detoriation. To record performance status (PS) as a routine for all patients might be helpful in that process. If the number of late cancellations could be reduced, resources at the clinic could be used more efficiently.
Additional file 6: of Transcriptome sequencing and analysis during seed growth and development in Euryale ferox Salisb
Creators: name: Liu, Xian
name: He, Zhen
name: Yin, Yulai
name: Xu, Xu
name: Wu, Weiwen
name: Li, Liangjun
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S4. The FDR of differentially expressed genes (DEGs) identified in pairwise comparisons of developmental stages in E. ferox seeds. (DOCX 15 kb)
Additional file 2 of The local burden of disease during the first wave of the COVID-19 epidemic in England: estimation using different data sources from changing surveillance practices
Creators: name: Nightingale, Emily S.
name: Abbott, Sam
name: Russell, Timothy W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 2. Final predicted-P1+P2 and total infections for the entire time series in each LTLA.
Additional file 1 of Influence of testing modality on bioefficacy for the evaluation of Interceptor® G2 mosquito nets to combat malaria mosquitoes in Tanzania
Creators: name: Kibondo, Ummi Abdul
name: Odufuwa, Olukayode G.
name: Ngonyani, Saphina H.
name: Mpelepele, Ahmadi B.
name: Matanilla, Issaya
name: Ngonyani, Hassan
name: Makungwa, Noel O.
name: Mseka, Antony P.
name: Swai, Kyeba
name: Ntabaliba, Watson
name: Stutz, Susanne
name: Austin, James W.
name: Moore, Sarah Jane
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Mosquito, control corrected mortality for laboratory mosquitoes after exposure to unwashed and washed Interceptor® G2 ITNs in WHO tunnel, Ifakara ambient chamber test, tunnel and wild strain in experimental hut test. Table S2. Blood-feeding inhibition of laboratory mosquitoes after exposure to unwashed and washed Interceptor® G2 ITNs in WHO tunnel, Ifakara ambient chamber test, tunnel and wild strain in experimental hut test. Table S3. Comparison of mosquito mortality and blood-feeding success in two hut designs, Ifakara, Tanzania. Table S4. Cost-effectiveness of WHO tunnel test, Ifakara ambient chamber test and experimental hut test in Tanzania.
Highly reproducible results of breast cancer biomarkers when analysed in accordance with national guidelines – a Swedish survey with central re-assessment
Creators: name: Ekholm, Maria
name: Grabau, Dorthe
name: Pär-Ola Bendahl
name: Bergh, Jonas
name: Elmberger, Göran
name: Olsson, Hans
name: Russo, Leila
name: Viale, Giuseppe
name: Fernö, Mårten
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Background. Biomarkers are crucial for decisions regarding adjuvant therapy in primary breast cancer, and their correct assessment is therefore of the utmost importance. Aims. To investigate the concordance between Swedish pathology departments and a reference laboratory, for routine analysis of oestrogen receptor (ER), progesterone receptor (PR), Ki67, and human epidermal growth factor receptor 2 (HER2), alone, and in combination (St Gallen subtypes). Methods. This survey included 27 of the 28 pathology laboratories in Sweden, covering 98% of cases of primary breast cancer surgery in Sweden. Paraffin-embedded tumour blocks (n = 270) were collected and sent to the central reference laboratory, together with the originally stained slides, for re-analysis. The primary evaluations were previously performed according to national Swedish guidelines, without any knowledge of the subsequent central assessment. Results. The agreement for ER, PR, and Ki67 was 99% [kappa value (κ) = 0.95], 95% (κ = 0.85), and 85% (κ = 0.70), respectively. The agreement for HER2 (0/1 + vs. 2+/3+) was 85% (κ = 0.64), but when equivocal tumours were further analysed with in situ hybridisation, only one discrepancy was observed. Discrepancies between results for ER and PR seem to be explained by analytical differences, whereas the interpretation of staining seems to be more critical for Ki67 and HER2 immunohistochemistry. The agreement between the results from the Swedish laboratories and the reference laboratory, based on the St Gallen subtypes, was 88% (κ = 0.81). Conclusions. When applying national guidelines, highly reproducible results were obtained in routine assessment of breast cancer biomarkers, and the results of this study confirm the clinical utility of these markers for decisions regarding the treatment of primary breast cancer.
Additional file 2 of Influence of testing modality on bioefficacy for the evaluation of Interceptor® G2 mosquito nets to combat malaria mosquitoes in Tanzania
Creators: name: Kibondo, Ummi Abdul
name: Odufuwa, Olukayode G.
name: Ngonyani, Saphina H.
name: Mpelepele, Ahmadi B.
name: Matanilla, Issaya
name: Ngonyani, Hassan
name: Makungwa, Noel O.
name: Mseka, Antony P.
name: Swai, Kyeba
name: Ntabaliba, Watson
name: Stutz, Susanne
name: Austin, James W.
name: Moore, Sarah Jane
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Fig. S1. A diagram on how to build the Ifakara ambient chamber test (I-ACT) and the cost to establish it.
Additional file 1: of Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Creators: name: Zhou, Xinrui
name: Zheng, Jie
name: Ivan, Fransiskus
name: Yin, Rui
name: Ranganathan, Shoba
name: Chow, Vincent
name: Kwoh, Chee-Keong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Phylogenetic trees of influenza A/H7N9. Time-scale phylogenetic trees of PB2, PB1, PA, HA, NP, NA, M1 and NS1 genes of influenza H7N9 strains. (PDF 117 kb)
Additional file 1: of SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer
Creators: name: Chen, Xu
name: Wang, Ya-Wen
name: Gao, Peng
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Figure S1 and Figure S2. SPIN1 expression in breast cancer cells and miR-148a-3p/148b-3p/152-3p expression in xenograft tumors. (DOC 261 kb)
Evaluation of fibrinogen concentrates and prothrombin complex concentrates on coagulation changes in a hypothermic in vitro model using thromboelastometry and thromboelastography
Creators: name: Durila, Miroslav
name: Lukáš, Pavel
name: Astraverkhava, Marta
name: Tomáš Vymazal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: Background. Hypothermic coagulopathy is very challenging in bleeding trauma patients. Therefore, we decided to evaluate the efficacy of fibrinogen and prothrombin complex in 30°C hypothermia in vitro to investigate if higher levels of fibrinogen and prothrombin complex concentrate can compensate for the hypothermic effect on coagulation as measured by thromboelastometry/thromboelastography. Methods. Blood samples were obtained from 12 healthy volunteers (six men and six women) in our study. Measurements were performed at 37°C and 30°C simultaneously, then at 30°C with adding fibrinogen and prothrombin complex and in the last step samples with added coagulation factors were warmed back to 37°C. Results. We found that 30°C hypothermic coagulopathy can be detected both by thromboelastometry and thromboelastography. Hypothermic coagulopathy can be restored by fibrinogen to the point where the results do not significantly differ from 37°C values (p > 0.05). After warming the sample with fibrinogen to 37°C, the thrombodynamic potential index was not significantly different from baseline (p > 0.05), although there was a trend to prothrombotic status. The addition of prothrombin complex concentrate to 30°C hypothermic sample was not able to correct hypothermic coagulopathy in vitro. Conclusions. Coagulopathy caused by the 30°C hypothermia in vitro model can be corrected by fibrinogen concentrate compared to prothrombin complex concentrate. In spite of a tendency to prothrombotic status, this was not significant with the use of the recommended dose of fibrinogen even after warming the blood to 37°C. However, measurement performed at 37°C seems to be safer than at 30°C.
Developing a set of policy recommendations to assist the promotion of residential energy efficiency programmes in Myanmar
Creators: name: Anandarajah, Gabrial
name: Cronin, Jen
name: Paing, Aung Thet
name: Yee, Myat Wutt
name: Aung, Soe Pyae
Publisher: name: Zenodo
Year: 2019
Subjects: Myanmar
Policy brief
Energy Efficiency

description: This document presents guidance to assist the Myanmar Government to formulate policies and strategies that can help to further enhance energy efficiency improvement activities in the Myanmar residential sector. It builds on the MECON research project findings and was co-developed through a stakeholder engagement workshop, which was organised in Nay Pyi Taw in May 2019 and was attended by 26 delegates representing a range of academics, energy industry representatives, development organisations, and policy makers representing various ministries. The first draft of the document was presented to senior policy makers in the Myanmar Ministry of Industry and their feedback was incorporated. Four key topics were discussed in the stakeholder workshop, deeper analysis of which could reduce the energy efficiency gap in the residential sector: uncertainty and risks; learning-by-doing to remove information barriers; principal agent issues and consumer heterogeneity. The rest of this document summarises how the policies and implementation activities can be improved, given understanding from the MECON project, recent progress and reflections from the workshop.
Prevalence of glucose-6-phosphate dehydrogenase deficiency and diagnostic challenges in 1500 immigrants in Denmark examined for haemoglobinopathies
Creators: name: Warny, Marie
name: Klausen, Tobias Wirenfeldt
name: Petersen, Jesper
name: Birgens, Henrik
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Similar to the thalassaemia syndromes, glucose-6-phosphate dehydrogenase (G6PD) deficiency is highly prevalent in areas historically exposed to malaria. In the present study, we used quantitative and molecular methods to determine the prevalence of G6PD deficiency in a population of 1508 immigrants in Denmark. We found the allele frequency to be between 2.4 and 2.9% in the female immigrants. Furthermore, the mutation pattern in the studied population showed a high prevalence of the G6PD A-202A variant in African and African-American immigrants, a high prevalence of the G6PD Mediterranean variant in Mediterranean European and Western Asian immigrants, and substantial heterogeneity in the variants found in the Eastern Asian/Pacific immigrants. Inasmuch as many of the patients included in this investigation had various thalassaemic syndromes, we were able to evaluate the effects of the interaction between a low mean corpuscular haemoglobin (MCH) value and G6PD activity, particularly in heterozygous females. The activity level was markedly influenced by the MCH value in females with normal G6PD activity, but not in heterozygous and homozygous females. Comparison of patients with normal G6PD activity and heterozygous females indicated considerable overlap in activity levels. To help separating heterozygous females from females with wild-type genes, a DNA analysis is necessary when the female activity level is between 4.0 and 4.9 U/g hgb corresponding to 50–60% of the median activity of unaffected males.
Additional file 2: of Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Creators: name: Zhou, Xinrui
name: Zheng, Jie
name: Ivan, Fransiskus
name: Yin, Rui
name: Ranganathan, Shoba
name: Chow, Vincent
name: Kwoh, Chee-Keong
Publisher: name: figshare
Year: 2018
Subjects: Biophysics
Biochemistry
Space Science
Cell Biology
Molecular Biology
Pharmacology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Superimpose the best and worst docked HA-ligand complexes. Visualize the structure of docked SH13-LSTa, SH13-LSTc, TW17-LSTa and TW17-LSTc complexes with the highest and the lowest binding affinities. (PDF 466 kb)
Additional file 3: of Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Creators: name: Zhou, Xinrui
name: Zheng, Jie
name: Ivan, Fransiskus
name: Yin, Rui
name: Ranganathan, Shoba
name: Chow, Vincent
name: Kwoh, Chee-Keong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Energy decomposition of HA-ligand complexes. VdW energy, electrostatic energy and total interaction energy of SH13-LSTa, SH13-LSTc, TW17-LSTa and TW17-LSTc. (PDF 702 kb)
Characterisation of the antiproliferative constituents and activity of Ficus exasperata (Vahl) on ovarian cancer cells –a preliminary investigation
Creators: name: Enitome E. Bafor
name: McKenna, Jennifer
name: Rowan, Edward G.
name: RuAngelie Edrada-Ebel
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: Ovarian cancer is one of the most common gynaecological cancers today. This study therefore investigates the anticancer effects of Ficus exasperata extracts and fractions on ovarian cancer cells. The antiproliferative activity of the crude extracts (1 mg/mL) was assessed using the MTT assay on A2780 (ovarian cancer) cell line. Bio-activity guided fractionation was performed and preliminary identification was further achieved using high resolution mass spectrometry and nuclear magnetic resonance spectroscopy. All crude extracts tested exhibited antiproliferative activity except for the methanol extract which interestingly showed proliferative effects. Five fatty acids were identified from the active fractions (FB1-10 and FB1-12). FB1-12 exhibited an IC50 value of 15.20 μg/mL. The least potent fraction (FB1-4 + 5) had an IC50 value of 34.51 μg/mL. H1-HEX and H1-MET exhibited 97.2 and 97.9%, respectively, compared to control. This study therefore provides proof-of-principle that fatty acids of Ficus exasperata exhibit significant antiproliferative effects on ovarian cancer cells.
Proximity and power in collaborative innovation projects
Creators: name: Hansen, Teis
name: Jannika Mattes
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Proximity and power in collaborative innovation projects. Regional Studies. The proximity literature has so far paid little attention to power relations in collaborative innovation projects. This paper draws on contributions from international business to examine if power constellations between collaborators in innovation projects influence the effects of proximity. An analysis of two cases of collaborations between headquarters and subsidiaries of multinational companies highlights that specific power constellations indeed influence the effects of proximity. While some forms of proximity allow subsidiary-specific capabilities to diffuse throughout the organization and pose a threat to the powerful subsidiary, the weaker subsidiary considers proximity as a possibility to learn from the headquarters.
MOESM1 of Microbial diversity and ecotoxicity of sediments 3Â years after the Jiaozhou Bay oil spill
Creators: name: Gao, Wei
name: Yin, Xiaofei
name: Mi, Tiezhu
name: Zhang, Yiran
name: Lin, Faxiang
name: Han, Bin
name: Zhao, Xilong
name: Luan, Xiao
name: Cui, Zhisong
name: Zheng, Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1: Figure S1. PCA results of the sampling sediments. Figure S2. The standard curve of the biotoxicity analysis.
Essential oil constituents and antimicrobial activity of Pycnocycla bashagardiana Mozaff. from Iran
Creators: name: Ardalan Alizadeh
name: Abdollahzadeh, Hamid
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Pycnocycla bashagardiana is a rare endemic and endangered species that has been used in folkloric medicine in Southern Iran. This study aimed to evaluate the essential oil constituents and antimicrobial activity of wild and cultivated p. bashagardiana. The aerial parts of wild and cultivated plants were collected from two provinces of Iran. The essential oil was isolated by hydrodistillation and analyzed by a combination of capillary GC and GC-MS. The main components in wild plants were myristicin (39.12%), (E)-β-ocimene (21.97%), sabinene (15.0%) and cis-iso-miristicin (2.67%) and in cultivated plants, (E)-β-ocimene (55.40%), myristicin (18.27%), (Z)-β-ocimene (12.47%) and cis-iso-miristicin (2.94%) were the main constituents in essential oil. The in vitro antimicrobial activity of the essential oil of P. bashagardiana were studied against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Candida albicans for the first time. The results showed that the oil exhibited strong antimicrobial activity against all the tested pathogens.
Additional file 4: of Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Creators: name: Zhou, Xinrui
name: Zheng, Jie
name: Ivan, Fransiskus
name: Yin, Rui
name: Ranganathan, Shoba
name: Chow, Vincent
name: Kwoh, Chee-Keong
Publisher: name: figshare
Year: 2018
Subjects: Biophysics
Biochemistry
Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Computational Biology

description: Two rounds of 50Â ns molecular dynamics simulation for SH13-LSTa, SH13-LSTc, TW17-LSTa, TW17-LSTc. Average total binding energy (kJ/mol) of the HA-LSTa/LSTc complexes. (PDF 424 kb)
Additional file 5: of Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Creators: name: Zhou, Xinrui
name: Zheng, Jie
name: Ivan, Fransiskus
name: Yin, Rui
name: Ranganathan, Shoba
name: Chow, Vincent
name: Kwoh, Chee-Keong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Residues contribution during the whole simulation process. The convergence analysis of energy contribution for residues involved in HA-ligand interaction. (PDF 153 kb)
title: 01_1531
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 6: of Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses
Creators: name: Zhou, Xinrui
name: Zheng, Jie
name: Ivan, Fransiskus
name: Yin, Rui
name: Ranganathan, Shoba
name: Chow, Vincent
name: Kwoh, Chee-Keong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Average energy contribution of residues that involved in receptor-ligand interactions in the optimally docked complexes. (PDF 24 kb)
Supplementary Material for: Effects of in utero and Postnatal Exposure to Secondhand Smoke on Lung Function by Gender and Asthma Status: The Seven Northeastern Cities (SNEC) Study
Creators: name: Hu, L.-W.
name: Yang, M.
name: Chen, S.
name: Shah, K.
name: Hailegiorgis, Y.
name: Burgens, R.
name: Vaughn, M.
name: Huang, J.
name: Xaverius, P.
name: Paul, G.
name: Morawska, L.
name: Lu, T.
name: Lin, S.
name: Zhong, S.-Q.
name: Kong, M.-L.
name: Xie, Y.-Q.
name: Hao, Y.-T.
name: Zeng, X.-W.
name: Qian, Z.
name: Dong, G.-H.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Little information exists on whether gender or asthma status modifies the effects of secondhand smoke (SHS) exposure on lung function. Objective: To evaluate whether gender or asthma status modifies the association of SHS exposure with lung function. Methods: A total of 6,740 children (average 11.6 years) were recruited from 24 districts of 7 cities in northeast China in 2012. SHS exposure included exposure to environmental and maternal smoking both in utero and during early childhood (postnatal). Lung function was measured using electronic spirometers. Two-step regressions were used to analyze the association between SHS and lung function. Results: In utero and postnatal exposure to SHS was independently associated with decreased lung function in both genders; however, this association was greater among males. For example, when exposed to maternal smoking during pregnancy, the adjusted odds ratio (aOR) for decreased forced vital capacity (FVC) was 6.46 (95% confidence interval [CI]: 2.58-16.17) among males, while only 2.16 (95% CI: 0.96-4.88) among females. More positive associations between SHS exposure and decreased lung function were detected among nonasthmatic compared with asthmatic children. Nonasthmatics had significantly larger deficits from in utero exposure to maternal smoking, which concerned decreased lung FVC function (aOR = 2.58, 95% CI: 1.28-5.21) and decreased lung forced expiratory volume in 1 s (FEV1) function (aOR = 2.32, 95% CI: 1.01-5.33). A similar pattern was also observed for the associations between SHS exposure and continuous pulmonary function test measurements. Conclusions: SHS exposure was associated with decreased lung function. Males and nonasthmatics seem to be more susceptible than their respective counterparts.
Additional file 1: of Mortality trends among people with hepatitis B and C: a population-based linkage study, 1993-2012
Creators: name: Alavi, Maryam
name: Grebely, Jason
name: Hajarizadeh, Behzad
name: Amin, Janaki
name: Larney, Sarah
name: Law, Matthew
name: George, Jacob
name: Degenhardt, Louisa
name: Dore, Gregory
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Table S1. ICD-10 codes used to define cause-specific mortality and hospital admissions among people with an HBV and HCV notification, NSW 1993-2012, n = 150,403. Table S2. Cause-specific mortality among people with an HBV and HCV notification, NSW 1993-2012, by ICD-10 chapter, n = 150,403. Table S3. Unadjusted analysis of factors associated with liver-related mortality among people with an HBV notification, NSW 1993-2012, n = 57,929. Table S4. Unadjusted analysis of factors associated with liver-related mortality among people with an HCV notification, NSW 1993-2012, n = 96,250. Table S5. Other cause-related mortality among people with an HBV and HCV notification, NSW 1993-2012, by ICD-10 chapter and year of birth, n = 150,403. Table S6. Adjusted analysis of factors associated with liver-related mortality among people with an HBV and HCV notification, NSW 1993-2012, n = 150,403. (DOCX 50 kb)
Additional file 1: of Prediction of enhancer-promoter interactions via natural language processing
Creators: name: Zeng, Wanwen
name: Wu, Mengmeng
name: Jiang, Rui
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Tables and Supplementary Figures. (DOCX 302Â kb)
Supplementary background text, figures, and morphological and phylogenetic data used for interpretations in the main text from A new Late Cretaceous iguanomorph from North America and the origin of New World Pleurodonta (Squamata, Iguania)
Creators: name: DeMar, David G.
name: Conrad, Jack L.
name: Head, Jason J.
name: Varricchio, David J.
name: Wilson, Gregory P.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: This file contains supplementary text and 14 supplementary figures. The supplementary text provides (i) supplementary morphological descriptions; (ii) methodology on estimating squamate body-sizes; (iii) interpretations of the palaeoenvironmental setting of Magnuviator ovimonsensis and other relevant fossil iguanomorphs; (iv) new systematic interpretations of Late Cretaceous lizards previously assigned to Pleurodonta; (v) cladistic analysis methodologies and results; (vi) character scorings of Magnuviator ovimonsensis and Pariguana lancensis; (vii) information regarding CT and µCT scans; and (viii) a complete strict consensus tree and apomorphy list derived from our morphology-based cladistic analysis. The supplementary figures show additional specimen images, cladograms, and comparative body-size estimates of fossil and extant lizards. The text provides background information for interpretations made in the manuscript.
Additional file 1: of Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype
Creators: name: Yan, Zhao
name: Tian, Xiaoxi
name: Zhu, Jinyu
name: Lu, Zifan
name: Yu, Lifeng
name: Zhang, Dawei
name: Liu, Yanwu
name: Yang, Chongfei
name: Zhu, Qingsheng
name: Cao, Xiaorui
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supporting Information S1. Effects of Metformin on TNF-Îą, IL-6 and IL-10 production in RAW264.7. Supporting Information S2. Role of AMPK activation in the effect of metformin on the exposed in RAW264.7. Supporting Information S3. Characterizations. Figure S1. Effect of metformin on RAW264.7 cytokine production in response to UHMWPE particles and the effect on AMPK phosphorylation. Figure S2. Effect of metformin on RAW264.7 cytokine production with AICAR or Compound C in response to UHMWPE particles and the effect on AMPK phosphorylation. Figure S3. Full-length gels and blots of western blot results for phosphorylated AMPK (p-AMPK) and total AMPK (t-AMPK) in the different treatment groups. Figure S4. Full-length gels and blots of western blot results for phosphorylated AMPK (p-AMPK) and total AMPK (t-AMPK) in the different treatment groups with AICAR or Compound C. Figure S5. Full-length gels and blots of protein expression of iNOS, COX-2, Arg-1, p-AMPK, and t-AMPK among tissues from the different treatment groups. (DOC 1902Â kb)
Supplementary Methods and Results from Intra- and intersexual differences in parasite resistance and female fitness tolerance in a polymorphic insect
Creators: name: Willink, Beatriz
name: Svensson, Erik I.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The supplementary methods include information about our prior specifications and model diagnostics for MCMCglmm. The supplementary results summarize inter-population sample sizes, parasite infections and female fecundity.
Supplementary Figures for “Protection of large predators in a marine reserve alters size-dependent prey mortality” by R. L. Selden, S. D. Gaines, S. L. Hamilton, and R. R. Warner in Proceedings of the Royal Society B"
Creators: name: Selden, Rebecca L.
name: Gaines, Steven D.
name: Hamilton, Scott L.
name: Warner, Robert R.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Figures S1-S6
Supplementary material from "Global leaf sulphur stoichiometry and the relationships with nitrogen and phosphorus: phylogeny, growth form and environmental controls"
Creators: name: Zhang, Liangjian
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310303
subject: Ecological physiology

description: Supplementary material from "Global leaf sulphur stoichiometry and the relationships with nitrogen and phosphorus: phylogeny, growth form and environmental controls"