cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effects of interventions on quality of life, morbidity and consultation frequency in frequent attenders in primary care: A systematic review
Creators: name: Haroun, Dany
name: Smits, Frans
name: Faridi Van Etten-Jamaludin
name: Schene, Aart
name: Weert, Henk Van
name: Riet, Gerben Ter
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Patients visiting their GPs exceptionally often (frequent attenders, FAs) have high rates of somatic disease, emotional distress, psychiatric illnesses and social problems and require a disproportionate amount of their GPs’ time. Objectives: To summarize which types of FA have been studied and what the effects of interventions were on quality of life (QoL), symptom severity of underlying illness(es) and consultation frequency. To discover when patients are considered FAs. Methods: Systematic review of RCTs using a comprehensive search (MEDLINE, PsycINFO, CINAHL and EMBASE, from 1980 to August 2015) and no language restrictions. Two investigators extracted data. Results were summarized qualitatively. Results: We included 17 RCTs. Heterogeneity at the level of populations, interventions and outcomes precluded statistical pooling. In-depth analysis by GPs assessing a patient’s reasons for frequent attendance decreased consultation frequency by four to six per year. A small effect on symptom severity was noted in depressed FAs, although this finding was not replicated in a recent trial. Multi-component therapy and medication in FAs with medically unexplained symptoms (MUS) improved QoL (SF36 odds ratio: 1.92; 95%CI: 1.08–3.40) and morbidity (CES-D 3.17; 95%CI: 1.27–5.08). Conclusion: RCTs on intervention effects in frequent attenders to primary care used different patient populations, interventions, comparators and outcome measures. Consistent evidence on the effects of particular interventions in specific patient domains is lacking. A tailored approach based on in-depth analysis among GPs of potential reasons for frequent attendance may decrease consultation frequency. Research involving the screening and treating for FAs with MUS may be useful in future trials.
ОБ ОСОБЕННОСТЯХ ПУСКА ВЫСОКОВОЛЬТНЫХ АСИНХРОННЫХ ДВИГАТЕЛЕЙ ОТ ГЕНЕРАТОРОВ СОИЗМЕРИМОЙ МОЩНОСТИ СУДОВОЙ ЭЛЕКТРОЭНЕРГЕТИЧЕСКОЙ СИСТЕМЫ
Creators: name: А. Н. Рак
Publisher: name: Техническая эксплуатация водного транспорта: проблемы и пути развития
Year: 2020
Subjects: главный двигатель
судовая электростанция
показатели качества
асинхронный двигатель
электропривод
подруливающее устройство.

description: Увеличение мощности главных двигателей морских судов приводит к увеличению мощности судовых электростанций. Применение классов напряжения до 1 000 В приводит к увеличению массогабаритных показателей оборудования и увеличению токовых нагрузок. Следующим шагом к усовершенствованию судовых энергетических систем является переход к уровням напряжения выше 1 000 В. При этом важной остается проблема соблюдения показателей качества электрической энергии. Особое внимание здесь уделено пуску асинхронного электродвигателя подруливающего устройства как одного из наиболее мощных потребителей. Приведены методики, позволяющие определять параметры электропривода, параметры электродвигателя подруливающего устройства и показатели качества электрической энергии. Статья будет полезна не только электромеханикам, но и другим специалистам, занимающимся эксплуатацией судового энергетического оборудования.
Personenfreizügigkeit und Wohnungsmarkt : Schweiz : Entwicklung 2012
Creators: name: Graf, Silvio
name: Sager, Daniel
name: Jans, Armin
Publisher: name: Bundesamt für Wohnungswesen
Year: 2013
Subjects: Wohnungspreis
Wohnungsnachfrage
Personenfreizügigkeit
Wohnungsmarkt
333: Bodenwirtschaft und Ressourcen

description: Seit der Mitte des vergangenen Jahrzehnts beeinflusst die Einführung der Personenfreizügigkeit die Einwanderungsrate in die Schweiz. Zu beobachten sind strukturelle Änderungen der Zuwanderung, einerseits was die Herkunft, andererseits was die Qualifikation der Ausländer betrifft. Immer mehr Zuwanderer stammen aus Ländern der europäischen Union und ihr Qualifikationsniveau ist höher als früher. Dies wirkt sich auch auf den Markt für Wohnimmobilien aus.
Mengen und Preise der OKP-Leistungen : eine statistische Analyse der Jahre 2004 bis 2010
Creators: name: Schleiniger, Reto
name: Blöchliger, Jonas
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2012
Subjects: Gesundheitskosten
Produktivitätsanalyse
OKP
362.1041: Gesundheitsökonomie

description: Die vorliegende Studie schlüsselt die kantonalen OKP-Kosten der Jahre 2004 bis 2010 in Mengen und Preise auf. Damit lassen sich in einem Querschnitt die kantonalen Kostendifferenzen in Mengen-und Preisdifferenzen und in einem Längsschnitt das Kostenwachstum in ein Mengen-und Preiswachstum unterteilen. In einem zweiten Schritt werden die kantonalen Mengenunterschiede mit einer ökonometrischen Analyse auf verschiedene Einflussfaktoren hin untersucht.
4D-QSAR investigation and pharmacophore identification of pyrrolo[2,1-c][1,4]benzodiazepines using electron conformational–genetic algorithm method
Creators: name: A. Özalp
name: S. Ç. Yavuz
name: N. Sabancı
name: F. Çopur
name: Z. Kökbudak
name: E. Sarıpınar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: In this paper, we present the results of pharmacophore identification and bioactivity prediction for pyrrolo[2,1-c][1,4]benzodiazepine derivatives using the electron conformational–genetic algorithm (EC–GA) method as 4D-QSAR analysis. Using the data obtained from quantum chemical calculations at PM3/HF level, the electron conformational matrices of congruity (ECMC) were constructed by EMRE software. The ECMC of the lowest energy conformer of the compound with the highest activity was chosen as the template and compared with the ECMCs of the lowest energy conformer of the other compounds within given tolerances to reveal the electron conformational submatrix of activity (ECSA, i.e. pharmacophore) by ECSP software. A descriptor pool was generated taking into account the obtained pharmacophore. To predict the theoretical activity and select the best subset of variables affecting bioactivities, the nonlinear least square regression method and genetic algorithm were performed. For four types of activity including the GI50, TGI, LC50 and IC50 of the pyrrolo[2,1-c][1,4] benzodiazepine series, the r2train, r2test and q2 values were 0.858, 0.810, 0.771; 0.853, 0.848, 0.787; 0.703, 0.787, 0.600; and 0.776, 0.722, 0.687, respectively.
DATASET: Farmers’ knowledge, perceptions and management of chili pepper anthracnose disease in Bangladesh
Creators: name: Islam, Abu Hayat Md Saiful
name: Schreinemachers, Pepijn
name: Kumar, Sanjeet
Publisher: name: Unknown
Year: 0
Subjects: PEPPERS
CAPSICUM ANNUUM
COLLETOTRICHUM
INTEGRATED PEST MANAGEMENT
PESTICIDES
ANTHRACNOSE
FARMERS

description: Plant diseases cause major crop yield losses and affect food security in lower-income countries. A limited understanding by farmers about the identity of plant diseases, transmission pathways and appropriate management methods is a key, but underexposed, problem. This study uses a sample of 260 farmers producing chili pepper in Bangladesh to elucidate their knowledge, perceptions and management methods regarding chili anthracnose—a fungal disease caused by Colletotrichum species. The results show that virtually all farmers had experienced typical symptoms of anthracnose disease and farmers reported average crop yield losses of 4%. Yet, only 22% of the farmers knew that this was a fungal disease and only 25% could tell how the disease spreads in the field. Farmers solely relied on chemical pesticides to control anthracnose, while the use of biopesticides, soil covers and crop rotations was negligible and only 7% of the farmers used labelled seed. A sound understanding of farmers of the crop diseases they face, their transmission pathways, and appropriate management methods is essential for establishing effective pest control. These results clearly show much room for improving chili productivity and the income and health of farmers, by building their capacity to deal with anthracnose disease.
ปัจจัยเสี่ยงที่มีอิทธิพลต่ออัตราการเสียชีวิตในผู้ป่วยวัณโรคโรงพยาบาลบางละมุง ในปีงบประมาณ 2559-2561
Creators: name: พัชรินทร์ สุเมธวทานิย
Publisher: name: กองนวัตกรรมและวิจัย กรมควบคุมโรค
Year: 2563
Subjects: วัณโรค
เสียชีวิต
ปัจจัยเสี่ยง
เอดส์

description: วารสารควบคุมโรค, 46, 1, 94-105
Personenfreizügigkeit und Wohnungsmarkt : Entwicklung 2014 : Schweiz
Creators: name: Graf, Silvio
name: Jans, Armin
name: Sager, Daniel
Publisher: name: Bundesamt für Wohnungswesen
Year: 2015
Subjects: Wohnungspreis
Personenfreizügigkeit
Wohnungsmarkt
Mietpreis
333: Bodenwirtschaft und Ressourcen

description: Seit Mitte des vergangenen Jahrzehnts beeinflusst die Einführung der Personenfreizügigkeit die Einwanderungsrate in die Schweiz. Zu beobachten sind strukturelle Änderungen der Zuwanderung, einerseits was die Herkunft, andererseits was die Qualifikation der Ausländer betrifft. Immer mehr Zuwanderer stammen aus Ländern der europäischen Union und ihr Qualifikationsniveau ist höher als früher. Dies wirkt sich auch auf den Markt für Wohnimmobilien aus.
Rami Zwick and Amnon Rapoport (eds.): Experimental business research. Kluwer Academic Publishers, Boston Dordrecht London 2002, XV + 410 pp., ISBN 0-7923-7483-5
Creators: name: Slembeck, Tilman
Publisher: name: Springer
Year: 2002
Subjects: Experimentelle Wirtschaftsforschung
330: Wirtschaft

description: Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)
15068187_10802712_386708.jpg
Creators: name: Camaron, Lucia
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: Trabajamos en una de las mejores páginas porno de incestos donde ofrecemos vídeos xxx de madres con hijos, padres con hijas y mucho más.
ver la web
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title: Prioritization of rural youth in Nova Scotia: understanding rural school success with policy gaps
Creators: name: Fancy-Landry, Jessica
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: This study describes a qualitative exploration into rural school success in Nova Scotia and the prioritization of its rural youth in educational policy. Case study methodology was used to conduct research using interview and text analysis methods. Factors of success and their key components that rural school personnel perceive as priorities in their buildings and the representation that rural school youth in Nova Scotia receive were explored from a developed conceptual framework using High-Performing High-Needs (HPHN) rural schools (Barely & Beesley, 2007; McREL, 2005a; Canada Without Poverty, 2019). This thesis describes the important roles that key components such as community support, student well-being, teacher and student retainment, performance pressures and lack of policy play in the future of rural school success in Nova Scotia. The study concludes that the lack of Canadian, more narrowly Nova Scotian, rural education policy puts rural youth at a disadvantage in their quest to obtain a quality and equitable education. Recommendations are provided to narrow this policy gap, and strategies that rural school personnel deemed effective are shared. These strategies are recommended as guidelines into best practices in policy development to ensure that youth in rural Nova Scotia, and indeed other jurisdictions, have an equitable voice in their pursuit of an equitable and quality education.
Proyecto web de incestos
Creators: name: Camaron, Lucia
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: Trabajamos en una de las mejores páginas porno de incestos donde ofrecemos vídeos xxx de madres con hijos, padres con hijas y mucho más.
ver la web
Estamos haciendo muchas mejoras, como por ejemplo, subir los vídeos para que no tengas que ir a otra web, mejores descripciones, carga de la web con un potente CDN, maxcdn.com
DATASET: Availability of soil iron determines the distribution strategy and seed iron content in mungbean (Vigna radiata) plants
Creators: name: Nair, Ramakrishnan Madhavan
name: HanumanthaRao, Bindumadhava
name: Vemula, Anilkumar
name: Rathore, Abhishek
name: Brumbarova, Tzvetina
name: Ivanov, Rumen
Publisher: name: Unknown
Year: 0
Subjects: subject: MUNGBEANS
subject: VIGNA RADIATA
subject: IRON ACQUISITION
subject: PHENOLICS
subject: SOIL IRON AVAILABILITY
subject: SEED IRON CONTENT

description: Background and aims Mungbean (Vigna radiata) is an important nutrient-rich crop with an increasing significance as food in Asia and other parts of the world. The conditions under which mungbean grows on the field might vary significantly and therefore understanding the behavior of plants on different soil types is crucial for obtaining optimal nutrient yields. In particular, iron availability in the soil might significantly influence plant growth and the loading of this element in the seed. The consumption of iron is one of the major problems of human nutrition worldwide. Lack of iron causes iron deficiency anemia, the most common nutrient disorder, leading to major developmental penalties or even death. Here, we aimed at understanding how iron is taken up in mungbean and how increasing its availability in the soil changes the iron distribution within three popular mungbean varieties, NM-94, CN9-5 and Harsha. Approach and results We could show that mungbean secretes phenolic compounds to support its iron acquisition and observed significant quantitative variations in the phenolic release, and root-surface ferric reductase activity among the three varieties. We found that in terms of iron distribution between organs, plants react differently when grown on soils with significantly different Fe content. In standard soils, the CN9-5 and Harsha varieties tended to achieve better iron distribution towards the seed, and higher iron content than NM-94. On the contrary, on iron-rich soil iron distribution towards the seed in NM-94 was strongly enhanced and led to the highest content among the three varieties. The data provide important insights into the choice of mungbean varieties depending on the soil conditions.
Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5
Creators: name: Cirigliano, Angela
name: Stirpe, Alessandro
name: Menta, Sergio
name: Mori, Mattia
name: Dell’Edera, Domenico
name: Elah Pick
name: Negri, Rodolfo
name: Botta, Bruno
name: Rinaldi, Teresa
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The CSN complex plays a key role in various cellular pathways: through a metalloprotease activity of its Csn5 deneddylating enzyme, it regulates the activity of Cullin-RING ligases (CRLs). Indeed, Csn5 has been found amplified in many tumors, but, due to its pleiotropic effects, it is difficult to dissect its function and the involvement in cancer progression. Moreover, while growing evidences point to the neddylation function as a good target for drug development; specific inhibitors have not yet been developed for the CSN. Here, we propose the yeast Saccharomyces cerevisiae as a model system to screen libraries of small molecules as inhibitors of cullins deneddylation, taking advantage of the unique feature of this organism to survive without a functional CSN5 gene and to accumulate a fully neddylated cullin substrate. By combining molecular modeling and simple genetic tools, we were able to identify two small molecular fragments as selective inhibitors of Csn5 deneddylation function.
title: Rapport Chaire d'excellence Aristote Giulia Fabiano
Creators: name: Santelli, Emmanuelle
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Rapport relatif au projet de recherche réalisé par Giulia Fabiano, dans le cadre de la Chaire d'excellence Aristote.
Super organogelator based on tetrathiafulvalene with four amide derivatives and its F4TCNQ charge-transfer complex
Creators: name: Deyun Kong
name: Xia, Yan
name: Dongfeng Li
name: Ruibin Hou
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: A new series of tetrathiafulvalene-based organogelators endowed with four hydrophobic chains incorporating amide groups was synthesised and characterised. The resulting transparent organogels were obtained with organic solvents such as cyclohexane, carbon tetrachloride and chlorobenzene. Additionally, the length of the alkyl chain influenced the gelation ability of organogels. Considering the results, we concluded that compounds were ‘super gelators’. Interestingly, the gelators reacted with 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane to form charge-transfer (CT) complexes and binary organogels. 1HNMR and FT-IR revealed that cooperation of hydrogen bonding, π–π and CT interactions was the main driving force for formation of the native and CT gels. The scanning electron microscopy images of native xerogels revealed characteristic gelation morphologies of three-dimensional cross-linking networks, whereas the morphologies of CT complex xerogels showed amorphous rod-like aggregates. X-ray powder diffraction studies suggested that both gelator and CT complex maintained lamellar molecular packing mode in organogel phase.
Amphiphilic [tpy-MII-tpy] metallotriangles: synthesis, characterisation and hierarchical ordering
Creators: name: Ludlow, James M.
name: Saunders, Mary Jane
name: Mingjun Huang
name: Zaihong Guo
name: Moorefield, Charles N.
name: Cheng, Stephen Z. D.
name: Chrys Wesdemiotis
name: Newkome, George R.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Long chain (C16) alkylated metallocycles are synthesised and characterised. Their ordered aggregation was studied via TEM to gauge to the effects of molecular topology, solvent, counterion and metal centre(s) on morphology and nanoscale structure. The results indicate that their amphiphilicity significantly enhanced their self-ordering characteristics relative to controls and enabled the formation of nanoscale structures. Similar ordering was observed for both labile and non-labile analogues with SAXD showing comparable d-spacing values, suggesting the presence of intramolecular π–π stacking. Effect of counterion and solvent was studied with the non-labile system. Nanotubular, ribbon, or sheet-like structures were afforded depending upon conditions.
Artifacts - Anycast Agility: Network Playbooks to Fight DDoS
Creators: name: A S M Rizvi
name: Bertholdo, Leandro M.
name: Ceron, João
name: Heidemann, John
Publisher: name: Zenodo
Year: 2022
Subjects: Anycast
Distributed Denial of Service Attacks - DDoS
DNS
Traffic Engineering
BGP

description: In this document, we provide datasets and software tools related to our paper “Anycast Agility: Network Playbooks to Fight DDoS”. Our artifact contains several datasets generated from our anycast experiments and analysis. Our datasets provide a snapshot of the results that we generated during our experiments. Some of our experimental results are dependent on the current state of the network interconnections and policies. However, due to the anycast stability, we expect to get similar results if we redo the experiments now. Our published datasets support our key results and are publicly available. We also provide tools and scripts that can be useful for other researchers. We provide datasets and tools for measuring anycast agility against DDoS. Our datasets are available upon request. We provide datasets about the traffic distribution after BGP changes in testbeds, attack data from a DNS root server and from the Dutch National Scrubbing Center, other data related to anycast catchment stability, and other supporting data for our software tools. We provide codes for traffic estimation, for reproducing experiments, and for parsing the collected data.
description: This work is supported, in part, by the DHS HSARPA Cyber Security Division via contract number HSHQDC-17-R-B0004-TTA.02-0006-I and Netherlands Organisation for scientific research (4019020199).
description: {"references": ["https://doi.org/10.48550/arxiv.2006.14058", "https://ant.isi.edu/paaddos/index.html", "http://paaddos.nl/"]}
Improved nematic mesophase stability of benzoxazole-liquid crystals via modification of inter-ring twist angle of biphenyl unit
Creators: name: Dingqian Shi
name: Hu, Kun
name: Chen, Pei
name: Weisong Du
name: Aiai Gao
name: Chen, Ran
name: Xinbing Chen
name: Zhongwei An
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: A series of nematic heterocyclic liquid crystals, 2-(2ʹ-fluoro-4ʹ-alkoxy-1,1ʹ-biphenyl-4-yl)-benzoxazole derivatives (coded as nPF(2)PBx) bearing hydrogen (nPF(2)PBH), methyl (nPF(2)PBM) and nitro (nPF(2)PBN) terminal groups, respectively, are developped and investigated. The results show that the nematic mesophase stability is obviously improved via a slightly increase in the inter-ring twist angle between the planes of two phenyl rings in the biphenyl unit, where modification of the twist angle can be achieved by adjusting the position of the lateral monofluorine substituent from the outer to the inter ring of the biphenyl mesogenic core unit. Meanwhile, the inter-ring lateral fluorine substituent results in a decrease in both melting and clearing points but only a nematic mesophase with an acceptably wide mesophase range for nPF(2)PBx, and thus a potential application in liquid crystal display mixtures is expected, especially for the compounds nPF(2)PBM and nPF(2)PBN. The reduced π–π interaction/conjugation caused by the increased twist angle is considered as one of the possible reasons for the formation of a nematic mesophase.
Infiltration of F98 glioma cells in Fischer rat brain is temporary stimulated by radiation
Creators: name: Desmarais, Guillaume
name: Charest, Gabriel
name: Therriault, Hélène
name: Minghan Shi
name: Fortin, David
name: Bujold, Rachel
name: Mathieu, David
name: Benoit Paquette
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Purpose: Irradiation of brain stimulates the expression of inflammatory mediators, some of which can modify the ability of cancer cells to infiltrate the brain. In the present study, the time window during which this stimulation occurs was determined. Materials and methods: Brain of Fischer rat was irradiated (15 Gy) and expression of pro-inflammatory mediators IL-1β, IL-6 and TNF-α was measured from 4 h to 20 days post-irradiation. Level of the matrix metalloproteinase 2 (MMP-2) and prostaglandin E2 (PGE2) which can favor cancer cell infiltration were also measured. The F98 glioma cells were implanted either during (4 h post-irradiation) or after (10 days post-irradiation) the pro-inflammatory phase. Infiltration distance of F98 cells in brain parenchyma and the median survival time of the animals were determined. Results: Expression of IL-1β, IL-6 and TNF-α was significantly increased in the irradiated brains with a peak at 4 h post-irradiation. Implantation of F98 glioma cells 4 h post-irradiation reduced the median survival time of Fischer rats to 18 days, compared to 25 days when the F98 were implanted in non-irradiated brain. Irradiation of the brain increased the distance of infiltration of F98 cells and was associated with increased levels of MMP-2 and PGE2. Conversely, F98 cells implanted 10 days post-irradiation have infiltrated the brain over a shorter distance and the median survival time of rats was increased to 35 days. Conclusions: Cancer recurrence is frequently observed in GBM patients. A better understanding of the inflammatory response observed in irradiated brain could contribute to develop new therapeutic modalities to further increase the efficiency of radiotherapy.
Toward a Ludic Architecture. The Space of Play and Games
Creators: name: Walz, Steffen P.
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: Whether we think of a board game, an athletic competition in a stadium, a videogame, playful social networking on the World Wide Web, an Alternate Reality Game, a location-based mobile game, or any combination thereof: Ludic activities are, have, and take place in or at, spaces. “Toward a Ludic Architecture” is a pioneering publication, architecturally framing play and games as human practices in and of space. Filling the gap in literature, Steffen P. Walz considers game design theory and practice alongside architectural theory and practice, asking: how are play and games architected? What kind of architecture do they produce and in what way does architecture program play and games? What kind of architecture could be produced by playing and gameplaying? “Toward a Ludic Architecture” is a must-read for analyzing and designing play and games from an architectural standpoint. Such a contribution is particularly applicable in an era when games extend into physical, designed space that is increasingly permeated by devices, sensors, and information networks, allowing for rules and fictions to superimpose our everyday environments. Including a maze-like, episodic, and critical discussion of interweaving “play-grounds,” “Toward a Ludic Architecture” is a playful look at the conceptual space of play and games.
Complete genome sequence and SNPs of Raja pulchra (Rajiformes, Rajidae) mitochondria
Creators: name: Hwang, Jae Yeon
name: Gwi-Deuk Jin
name: Jongbin Park
name: Heebal Kim
name: Chang-Kyu Lee
name: Woori Kwak
name: Bo-Hye Nam
name: An, Cheul Min
name: Park, Jung Youn
name: Kyu-Hyun Park
name: Chul-Sung Huh
name: Kim, Eun Bae
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Mitochondrial genomes were sequenced from five Raja pulchra individuals, and single-nucleotide polymorphisms (SNPs) were identified by comparing previously announced sequences in this study. Total 117 SNPs were detected and they were present in 2 rRNA genes, 9 tRNA genes, 13 protein coding genes and non-coding region. One deleted polymorphic site, which was located in 16S rRNA gene, was observed in two individuals. Six polymorphic sites were non-synonymous SNPs, which were distributed in ND1, ND2, ATP6 and ND4 gene. Phylogenic analysis validated current taxa. The genome sequences of R. pulchra mitochondria could be comparable information for understanding species divergence and genomic variation among the populations.
Mitochondrial genome of Esox flaviae (Southern pike): announcement and comparison with other Esocidae
Creators: name: Gandolfi, Andrea
name: Fontaneto, Diego
name: Natali, Mauro
name: Lucentini, Livia
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Pikes are fish species belonging to order Esociformes, family Esocidae, genus Esox. Species of the genus Esox are common, large, and economically important for food and fishing activities. Recently, a new species, southern pike E. flaviae, was described for a well-studied area such as Italy, using also two mtDNA markers: cox1 and cytb. A scant number of remnant populations of the species persist in Italy, threatened by habitat loss and degradation and by competition and possible hybridization with E. lucius, massively and recurrently stocked to sustain angling pressure. The availability of new mtDNA markers will possibly contribute to the conservation of the species. Currently, whole mitogenome information for the genus is available only for E. lucius and for E. reichertii. The aim of the present paper is to report novel mitogenomic information for southern pike.
Thought-Provoking Play: Political Philosophies in Science Fictional Videogame Spaces from Japan
Creators: name: Roth, Martin
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: This book considers videogames as spaces of political philosophy. Emerging from a negotiation between designers, player and computer, they prompt us to rethink life in common and imagine alternatives to the status quo. Several case studies on science fictional videogames from Japan serve to demonstrate this potential for thought-provoking play.
Single-Index-Based CoVaR With Very High-Dimensional Covariates
Creators: name: Fan, Yan
name: Härdle, Wolfgang Karl
name: Weining Wang
name: Lixing Zhu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Systemic risk analysis reveals the interdependencies of risk factors especially in tail event situations. In applications the focus of interest is on capturing joint tail behavior rather than a variation around the mean. Quantile and expectile regression are used here as tools of data analysis. When it comes to characterizing tail event curves one faces a dimensionality problem, which is important for CoVaR (Conditional Value at Risk) determination. A projection-based single-index model specification may come to the rescue but for ultrahigh-dimensional regressors one faces yet another dimensionality problem and needs to balance precision versus dimension. Such a balance is achieved by combining semiparametric ideas with variable selection techniques. In particular, we propose a projection-based single-index model specification for very high-dimensional regressors. This model is used for practical CoVaR estimates with a systemically chosen indicator. In simulations we demonstrate the practical side of the semiparametric CoVaR method. The application to the U.S. financial sector shows good backtesting results and indicate market coagulation before the crisis period. Supplementary materials for this article are available online.
The Transmedia Way: A Storytellers, Communicators and Designers’ Guide to the Galaxy
Creators: name: Giovagnoli, Max
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: This book is an essay and a professional guide at the same time. It consists of all the most important masterworks and experiences, and is a “captain’s log” with 100 examples of the most relevant and original transmedia universes invented over the past years, from America to Europe, from Asia to Africa and Australia. The discussion is endorsed by the presence of first rated professionals and academics who list among the most important international producers, authors and scholars in transmedia history.
Equivalence Testing With Particle Size Distribution Data: Methods and Applications in the Development of Inhalative Drugs
Creators: name: Hoffelder, Thomas
name: Wellek, Stefan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Key criteria of the quality of inhalative drugs are assessed in experiments generating so-called particle size distributions as data. Many experiments of that kind are carried out to demonstrate that necessary modifications to whatever part of the manufacturing process do not substantially change basic characteristics of an inhalable drug product. The equivalence testing procedures we derive for that purpose rely on different models accommodating the specific structure of such data and on different ways of specifying the region of nonrelevant differences. For each hypotheses formulation, three different tests are derived (two parametric and one asymptotically distribution-free procedures) and compared in terms of level and power. The results support the conclusion that the asymptotically distribution-free procedure exhibits surprisingly favorable properties. Supplementary materials for this article are available online.
The Greatest Gift
Creators: name: Mazza, Ray
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: The Greatest Gift is a card game about trying to figure out what the other players would most like out of real life, and offering these things as gifts. In a series of rounds, players offer each other such gifts and are rewarded when their offered gifts are chosen above the others. The player that collects gifts the quickest wins the game.
Carbon Dioxide as a Tool to Deter the Movement of Invasive Bigheaded Carps
Creators: name: Donaldson, Michael R.
name: Amberg, Jon
name: Adhikari, Shivani
name: Cupp, Aaron
name: Jensen, Nathan
name: Romine, Jason
name: Wright, Adam
name: Gaikowski, Mark
name: Suski, Cory D.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Nonnative bigheaded carps are established in the Mississippi River and there is substantial concern about their potential entry into the interconnected Laurentian Great Lakes. While electrical barriers currently exist as a preventative measure, there is need for additional control mechanisms to promote barrier security through redundancy. We tested the effectiveness of infused carbon dioxide gas (CO2) as a tool to influence the movement and behavior invasive bigheaded carps, namely Bighead Carp Hypophthalmichthys nobilis and Silver Carp H. molitrix, as well as native Bigmouth Buffalo Ictiobus cyprinellus, Channel Catfish Ictalurus punctatus, Paddlefish Polyodon spathula, and Yellow Perch Perca flavescens in an experimental pond. Individuals were monitored with acoustic telemetry before, during, and after CO2 addition to the pond. We noted distinct changes in fish behavior following CO2 addition. Each species except Paddlefish maintained farther distances from the CO2 infusion manifold relative to controls. Both bigheaded carp species had slower persistence velocities (persistence of a movement in a given direction) following CO2 infusion and Bighead Carp used a smaller area of the pond immediately after CO2 addition. Pond pH progressively decreased up to 1.5 units following CO2 infusion. This work provides evidence that could inform future research to enhance existing control measures used to deter high-risk invasive fishes, such as bigheaded carps. Received July 27, 2015; accepted January 11, 2016 Published online April 27, 2016
Single index based CoVaR with very high dimensional covariates
Creators: name: Fan, Yan
name: Härdle, Wolfgang Karl
name: Weining Wang
name: Lixing Zhu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Systemic risk analysis reveals the interdependencies of risk factors especially in tail event situations. In applications the focus of interest is on capturing joint tail behavior rather than a variation around the mean. Quantile and expectile regression are used here as tools of data analysis. When it comes to characterizing tail event curves one faces a dimensionality problem, which is important for CoVaR (Conditional Value at Risk) determination. A projection based single index model specification may come to the rescue but for ultra high dimensional regressors one faces yet another dimensionality problem and needs to balance precision vs. dimension. Such a balance is achieved by combining semi parametric ideas with variable selection techniques. In particular, we propose a projection based single index model specification for very high dimensional regressors. This model is used for practical CoVaR estimates with a systemically chosen indicator. In simulations we demonstrate the practical side of the semiparametric CoVaR method. The application to the US financial sector shows good backtesting results and indicate market coagulation before the crisis period.
Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)
Creators: name: L. V. Laing
name: J. Viana
name: E. L. Dempster
name: M. Trznadel
name: L. A. Trunkfield
name: T. M. Uren Webster
name: R. Van Aerle
name: G. C. Paull
name: R. J. Wilson
name: J. Mill
name: E. M. Santos
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Bisphenol A (BPA) is a commercially important high production chemical widely used in epoxy resins and polycarbonate plastics, and is ubiquitous in the environment. Previous studies demonstrated that BPA activates estrogenic signaling pathways associated with adverse effects on reproduction in vertebrates and that exposure can induce epigenetic changes. We aimed to investigate the reproductive effects of BPA in a fish model and to document its mechanisms of toxicity. We exposed breeding groups of zebrafish (Danio rerio) to 0.01, 0.1, and 1 mg/L BPA for 15 d. We observed a significant increase in egg production, together with a reduced rate of fertilization in fish exposed to 1 mg/L BPA, associated with significant alterations in the transcription of genes involved in reproductive function and epigenetic processes in both liver and gonad tissue at concentrations representing hotspots of environmental contamination (0.1 mg/L) and above. Of note, we observed reduced expression of DNA methyltransferase 1 (dnmt1) at environmentally relevant concentrations of BPA, along with a significant reduction in global DNA methylation, in testes and ovaries following exposure to 1 mg/L BPA. Our findings demonstrate that BPA disrupts reproductive processes in zebrafish, likely via estrogenic mechanisms, and that environmentally relevant concentrations of BPA are associated with altered transcription of key enzymes involved in DNA methylation maintenance. These findings provide evidence of the mechanisms of action of BPA in a model vertebrate and advocate for its reduction in the environment.
Vegetation of semi-stable rangeland dunes of the Navajo Nation, Southwestern USA
Creators: name: Thomas, Kathryn A.
name: Redsteer, Margaret H.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Dune destabilization and increased mobility is a worldwide issue causing ecological, economic, and health problems for the inhabitants of areas with extensive dune fields. Dunes cover nearly a third of the Navajo Nation within the Colorado Plateau of southwestern USA. There, higher temperatures and prolonged drought beginning in 1996 have produced significant increases in dune mobility. Vegetation plays an important role in dune stabilization, but there are few studies of the plants of the aeolian surfaces of this region. We examined plant species and their attributes within a moderately vegetated dune field of the Navajo Nation to understand the types and characteristics of plants that stabilize rangeland dunes. These dunes supported a low cover of mixed grass-scrubland with fifty-two perennial and annual species including extensive occurrence of non-native annual Salsola spp. Perennial grass richness and shrub cover were positively associated with increased soil sand composition. Taprooted shrubs were more common on sandier substrates. Most dominant grasses had C4 photosynthesis, suggestive of higher water-use efficiencies and growth advantage in warm arid environments. Plant cover was commonly below the threshold of dune stabilization. Increasing sand movement with continued aridity will select for plants adapted to burial, deflation, and abrasion. The study indicates plants tolerant of increased sand mobility and burial but more investigation is needed to identify the plants adapted to establish and regenerate under these conditions. In addition, the role of Salsola spp. in promoting decline of perennial grasses and shrubs needs clarification.
Sequential change in one-pot, three-component protocol: A stepping stone in heterocyclic synthesis
Creators: name: Raja, Ranganathan
name: Murugan, Dinesh
name: Sivasubramaniyan, Archana
name: Jaabil George
name: Perumal, Sakthivel
name: Ponnuswamy Alagusundaram
name: Jayakumar, Mohan Raj
name: Murugavel Saminathan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Two different heterocycles, thiazole-2-imines and imidazole-2-thiones, have been conveniently synthesized by just altering the sequential order (1 + 2 + 3 or 1 + 3 + 2) when combining the same components [aryl amine (1), aryl isothiocyanate (2), and phenacyl bromide (3)] in one-pot, three-component protocols. The third possible sequential order of combination (2 + 3 + 1) chemoselectively affords thiazole-2-imine. The finding is a stepping stone in the synthetic applicability of sequential one-pot, three-component protocols.
Mining Documents and Sentiments in Cross-lingual Context
Creators: name: Saad, Motaz
Publisher: name: figshare
Year: 2016
Subjects: subject: 80107 Natural Language Processing
subject: FOS: Computer and information sciences

description: The aim of this thesis is to study sentiments in comparable documents. First, we collect English, French and Arabic comparable corpora from Wikipedia and Euronews, and we align each corpus at the document level. We further gather English-Arabic news documents from local and foreign news agencies. The English documents are collected from BBC website and the Arabic document are collected from Al-jazeera website. Second, we present a cross-lingual document similarity measure to automatically retrieve and align comparable documents. Then, we propose a cross-lingual sentiment annotation method to label source and target documents with sentiments. Finally, we use statistical measures to compare the agreement of sentiments in the source and the target pair of the comparable documents. The methods presented in this thesis are language independent and they can be applied on any language pair.