cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Berry Phase in Neutrino Oscillations
Creators: name: He, Xiao-Gang
name: Li, Xue-Qian
name: McKellar, Bruce H. J.
name: Zhang, Yue
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the Berry phase in neutrino oscillations for both Dirac and Majorana neutrinos. In order to have a Berry phase, the neutrino oscillations must occur in a varying medium, the neutrino-background interactions must depend on at least two independent densities, and also there must be CP violation if the neutrino interactions with matter are mediated only by the standard model W and Z boson exchanges which implies that there must be at least three generations of neutrinos. The CP violating Majorana phases do not play a role in generating a Berry phase. We show that a natural way to satisfy the conditions for the generation of a Berry phase is to have sterile neutrinos with active-sterile neutrino mixing, in which case at least two active and one sterile neutrinos are required. If there are additional new CP violating flavor changing interactions, it is also possible to have a non-zero Berry phase with just two generations.
description: RevTex 16 pages, no figures, new discussions about sterile neutrino added,typos corrected and errors in references corrected
Determining The Magnetic Potential In The Fractional Magnetic Calderón Problem
Creators: name: Li, Li
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35R11, 35R30

description: We determine both the magnetic potential and the electric potential from the exterior partial measurements of the Dirichlet-to-Neumann map in the fractional linear magnetic Calderón problem by using an integral identity. We also determine both the magnetic potential and the nonlinearity in the fractional semilinear magnetic Calderón problem by using a first order linearization.
description: 10 pages
Characterization of conditioned effects in the kindling model of epilepsy and neuroplasticity
Creators: name: Barnes, Steven John
Publisher: name: University of British Columbia
Year: 2009

description: Mild periodic electrical stimulation to any one of many brain sites leads to the development and progressive intensification of elicited convulsions. This "kindling phenomenon" has been widely studied as a model of epilepsy and neuroplasticity. We recently discovered that subjects in conventional kindling experiments learn the relationship between the stimulation environment and the subsequent stimulation and convulsion and that this conditioning has significant effects on both their convulsions and interictal (between convulsions) behaviour. Specifically, the convulsions of rats kindled from the basolateral amygdala (BA) were more severe in an environment in which they had always been stimulated than in an environment in which they had never been stimulated, and they displayed more interictal defensive behaviour in the stimulation environment. The objective of the present experiments was to establish the reliability, generality, nature, and theoretical significance of this discovery. This thesis comprises three different lines of experiments. The first line confirmed that the effects of the stimulation environment observed during BA kindling are the result of Pavlovian conditioning. The second line explored the conditioned effects associated with the kindling of brain structures other than the BA; the results suggested that kindling site determines the conditioned effects of the stimulation environment on convulsions and interictal behaviour. The third line demonstrated that conditioned effects contribute substantially to two of the defining features of the kindling phenomenon: its permanence (If a rat is left unstimulated for several months, fully generalized convulsions are quickly elicited once kindling recommences.) and its "transfer" between brain sites (If a rat is kindled from one brain site, it subsequently requires fewer stimulations to kindle from a second brain site.). The present results not only characterize the conditioned effects of kindling, they also indicate that such effects are a general and reliable component of kindling. Clearly, the key to discovering the mechanisms underlying kindling lies, to a large degree, in the interactions of the subjects with the cues that predict each stimulation and not solely in the unconditioned consequences of the brain stimulations and convulsions.
Additional file 1 of Quality of life up to 10 years after traumatic brain injury: a cross-sectional analysis
Creators: name: Rauen, Katrin
name: Reichelt, Lara
name: Probst, Philipp
name: Schäpers, Barbara
name: Müller, Friedemann
name: Jahn, Klaus
name: Plesnila, Nikolaus
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file1: Figure S1. Cross-sectional study design.
Bigrassmannian permutations and Verma modules
Creators: name: Ko, Hankyung
name: Mazorchuk, Volodymyr
name: Mrđen, Rafael
Publisher: name: arXiv
Year: 2020
Subjects: subject: Representation Theory (math.RT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We show that bigrassmannian permutations determine the socle of the cokernel of an inclusion of Verma modules in type $A$. All such socular constituents turn out to be indexed by Weyl group elements from the penultimate two-sided cell. Combinatorially, the socular constituents in the cokernel of the inclusion of a Verma module indexed by $w\in S_n$ into the dominant Verma module are shown to be determined by the essential set of $w$ and their degrees in the graded picture are shown to be computable in terms of the associated rank function. As an application, we compute the first extension from a simple module to a Verma module.
description: 18 pages
Large deviations of a modified Jackson network: stability and rough asymptotics
Creators: name: Foley, Robert D.
name: McDonald, David R.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K25 (Primary) 60K20. (Secondary)

description: Consider a modified, stable, two node Jackson network where server 2 helps server 1 when server 2 is idle. The probability of a large deviation of the number of customers at node one can be calculated using the flat boundary theory of Schwartz and Weiss [Large Deviations Performance Analysis (1994), Chapman and Hall, New York]. Surprisingly, however, these calculations show that the proportion of time spent on the boundary, where server 2 is idle, may be zero. This is in sharp contrast to the unmodified Jackson network which spends a nonzero proportion of time on this boundary.
description: Published at http://dx.doi.org/10.1214/105051604000000666 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Software Test Automation Maturity -- A Survey of the State of the Practice
Creators: name: Wang, Yuqing
name: Mäntylä, Mika V.
name: Demeyer, Serge
name: Wiklund, Kristian
name: Eldh, Sigrid
name: Kairi, Tatu
Publisher: name: arXiv
Year: 2020
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The software industry has seen an increasing interest in test automation. In this paper, we present a test automation maturity survey serving as a self-assessment for practitioners. Based on responses of 151 practitioners coming from above 101 organizations in 25 countries, we make observations regarding the state of the practice of test automation maturity: a) The level of test automation maturity in different organizations is differentiated by the practices they adopt; b) Practitioner reported the quite diverse situation with respect to different practices, e.g., 85\% practitioners agreed that their test teams have enough test automation expertise and skills, while 47\% of practitioners admitted that there is lack of guidelines on designing and executing automated tests; c) Some practices are strongly correlated and/or closely clustered; d) The percentage of automated test cases and the use of Agile and/or DevOps development models are good indicators for a higher test automation maturity level; (e) The roles of practitioners may affect response variation, e.g., QA engineers give the most optimistic answers, consultants give the most pessimistic answers. Our results give an insight into present test automation processes and practices and indicate chances for further improvement in the present industry.
ИСТОРИЯ И ПСИХОЛОГИЯ ТАНЦА В УЗБЕКИСТАНЕ: ОТ ДОИСЛАМСКОГО ПЕРИОДА ДО СОВРЕМЕННОСТИ
Creators: name: Аль-Шейхаб, Захраа
Publisher: name: Zenodo
Year: 2024

description: С древних времен до современности танец играл значительную роль в жизни узбекского народа, отражая его духовные и социальные аспекты. В доисламском Узбекистане танец был не просто формой искусства, но и важной частью религиозных обрядов, социального взаимодействия и культурной идентичности. Сегодня танец используется как средство психологической саморегуляции и терапии.
The Aschenbach effect: unexpected topology changes in motion of particles and fluids orbiting rapidly rotating Kerr black holes
Creators: name: Stuchlik, Z.
name: Slany, P.
name: Torok, G.
name: Abramowicz, M. A.
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Newton's theory predicts that the velocity $V$ of free test particles on circular orbits around a spherical gravity center is a decreasing function of the orbital radius $r$, $dV/dr < 0$. Only very recently, Aschenbach (A&A 425, p. 1075 (2004)) has shown that, unexpectedly, the same is not true for particles orbiting black holes: for Kerr black holes with the spin parameter $a>0.9953$, the velocity has a positive radial gradient for geodesic, stable, circular orbits in a small radial range close to the black hole horizon. We show here that the {\em Aschenbach effect} occurs also for non-geodesic circular orbits with constant specific angular momentum $\ell = \ell_0 = const$. In Newton's theory it is $V = \ell_0/R$, with $R$ being the cylindrical radius. The equivelocity surfaces coincide with the $R = const$ surfaces which, of course, are just co-axial cylinders. It was previously known that in the black hole case this simple topology changes because one of the ``cylinders'' self-crosses. We show here that the Aschenbach effect is connected to a second topology change that for the $\ell = const$ tori occurs only for very highly spinning black holes, $a>0.99979$.
description: 9 pages, 7 figures
MFCs with maximised power outputs for integration in GrowBots
Creators: name: Costa, Rubén Darío
name: Uria, Naroa
name: Nunziata, Cybeles
name: Morales, John Arturo
Publisher: name: Zenodo
Year: 2021
Subjects: Horizon 2020
GrowBot project
Research and Innovation Action
MFC
PMFC
Energy Harvesting

description: Deliverable D7.1 containing Task 7.1 Microbial fuel cells (MFCs) for topsoil energy harvesting (Bioo, month 7-24):
 'GrowBot aims to achieve an energetic independence, becoming an autonomous system during its operation phase. We will develop autonomous MFCs that can provide energy to the robot and, in addition, do not require of a continuous monitoring of the cell conditions'.
description: Publication developed within the GrowBot project, funded by the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 824074.
Error Filtration and Entanglement Purification for Quantum Communication
Creators: name: Gisin, N.
name: Linden, N.
name: Massar, S.
name: Popescu, S.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The key realisation which lead to the emergence of the new field of quantum information processing is that quantum mechanics, the theory that describes microscopic particles, allows the processing of information in fundamentally new ways. But just as in classical information processing, errors occur in quantum information processing, and these have to be corrected. A fundamental breakthrough was the realisation that quantum error correction is in fact possible. However most work so far has not been concerned with technological feasibility, but rather with proving that quantum error correction is possible in principle. Here we describe a method for filtering out errors and entanglement purification which is particularly suitable for quantum communication. Our method is conceptually new, and, crucially, it is easy to implement in a wide variety of physical systems with present day technology and should therefore be of wide applicability.
description: 23 pages (latex) and 4 postscript figures
CONSTRAINTS TO EXPANSION OF COWPEA AND MUNGBEAN UNDER RAIN-FED FARMING IN ANURADHAPURA DISTRICT
Creators: name: Hewavitharane, H.V.C.
name: Warnakulasooriya, H.U.
name: Wajira Kumara, G.B.S.
name: Hewavitharane, H.V.C.
name: Warnakulasooriya, H.U.
name: Wajira Kumara, G.B.S.
Publisher: name: Unknown
Year: 2010
Subjects: subject: Crop Production/Industries
subject: Cost of cultivation
subject: Family labour
subject: Rain-fed farming
subject: Variety attributes

description: Cowpea and mungbean extents in Sri Lanka have declined over the last decade. This study analyzes the reasons for these declining trends under rain-fed farming, estimating the adoption percentages, preferences for variety attributes, profitability, and production functions. Primary data relevant to 2008/09 maha season were collected from random samples of 40 cowpea and 33 mungbean farmers of Anuradhapura district. The per hectare and per farm profitability estimates including (excluding) imputed cost of family labour were Rs 21,662 (Rs 81,423) and Rs. 3,682 (Rs. 14,420), respectively, for cowpea and Rs. -16,289 (Rs. 43,612) and Rs. -1,648 (Rs. 4,242), respectively, for mungbean. The share of family labour in total cost is 89% for cowpea and 76% for mungbean. The variety adoption rate was 38% for ‘Bombay’ cowpea, 33% for ‘Arlington’ cowpea, and 49% for ‘MI 6’ Mungbean. Largeness of seed, glossiness of seed coat, and indeterminate growth patterns are the variety attributes preferred by farmers of both cowpea, and mungbean. The production function estimates showed that cowpea varieties ‘Bombay’ and ‘Arlington’ significantly outperform (p<0.05) ‘Dhawala’, whereas mungbean varieties ‘MI 06’ and ‘MI 05’ significantly outperform (p<0.05) the local varieties. Family labour constraint is a critical determinant in deciding farm size of both crops.
description: Published in: Annals of the Sri Lanka Department of Agriculture 2010.12.91-104
Generalization of the DGLAP for the structure function g_1 to the region of small x
Creators: name: Ermolaev, B. I.
name: Greco, M.
name: Troyan, S. I.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The explicit expressions for the non-singlet and singlet components of the DIS structure function g_1 comprising the DGLAP -expressions for the coefficient functions and the anomalous dimensions, and accounting for the total resummation of the most singular contributions to those are obtained.
description: Talk given at 16th International Spin Physics Symposium (SPIN 2004), Trieste, Italy, 10-16 Oct 2004. 3 pages. 1 figure
Generalized Einstein's and Brinkman's solutions for the effective viscosity of nanofluids
Creators: name: Solyaev, Y. O.
name: Lurie, S. A.
name: Semenov, N. A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: In this paper, we derive the closed form analytical solutions for the effective viscosity of the suspensions of solid spheres that take into account the size effects. This result is obtained using the solution for the effective shear modulus of particulate composites developed in the framework of the strain gradient elasticity theory. Assuming incompressibility of matrix and rigid behavior of particles and using a mathematical analogy between the theory of elasticity and the theory of viscous fluids we derive the generalized Einstein's formula for the effective viscosity. Generalized Brinkman's solution for the concentrated suspensions is derived then using differential method. Obtained solutions contain single additional length scale parameter, which can be related to the interactions between base liquid and solid particles in the suspensions. In the case of the large ratio the between diameter of particles and the length scale parameter, developed solutions reduce to the classical solutions, however for the small relative diameter of particles an increase of the effective viscosity is predicted. It is shown that developed models agree well with known experimental data. Solutions for the fibrous suspensions are also derived and validated.
Rice price policies in Indonesia : a computable general equilibrium (CGE) analysis
Creators: name: Robinson, Sherman
name: El-Said, Moataz
name: San, Nu Nu
name: Suryana, Achmad
name: Hermanto, Bahri Sjaiful
name: Swastika, Dewa K.S.
name: Robinson, Sherman
name: El-Said, Moataz
name: San, Nu Nu
name: Suryana, Achmad
name: Hermanto, Bahri Sjaiful
name: Swastika, Dewa K.S.
Publisher: name: Unknown
Year: 1997
Subjects: subject: Crop Production/Industries
subject: Demand and Price Analysis
subject: Rice -- Yields -- Indonesia
subject: Price regulation -- Indonesia
subject: Computable general equilibrium (CGE)
subject: Agricultural resources

description: This paper presents an agriculture sector focused Computable General Equilibrium (AG-CGE) model for analyzing the economy-wide impacts of changes in technology, protection, and market structure on resource allocation, production, and trade in Indonesia. The paper incorporates a specification of the rice market and models the government price-support, stocking, and trade policies for rice using a mixed complementarity approach. This approach allows the specification of inequalities and changes in policy regime as prices and/or stocks move within specified bands. The model is used to examine the impact on the Indonesian economy of changes in rice yields given different assumptions about the operations of Bulog (National Logistic Agency). The general equilibrium approach captures and quantifies the effects of the price support policies on resource allocation, trade, relative prices, and the government budget. An important result is that there is inefficient allocation of resources within the agriculture sector and the rest of the economy if Bulog operates to maintain the rice price when there are significant increases in rice productivity. Instead of releasing resources to other high-value agriculture uses and non-agriculture uses, the price support scheme attracts more resources into rice production. In addition, the price support program is costly and strains the government accounts, even if the administrative costs of operating the program are ignored.
description: Cover title. "June 1997"--Cover. Includes bibliographical references (p. 46-48).
The 1990's global grain situation and its impact on the food security of selected developing countries
Creators: name: Friedberg, Mark
name: Thomas, Marcelle
name: Friedberg, Mark
name: Thomas, Marcelle
Publisher: name: Unknown
Year: 1997
Subjects: subject: Crop Production/Industries
subject: Food Security and Poverty
subject: Grain production
subject: Food security -- Developing countries
subject: Grain -- Prices
subject: Africa -- Economic conditions
subject: Asia -- Economic conditions
subject: Latin America -- Economic conditions
subject: Middle East -- Economic conditions

description: Between 1993 and 1996, two developments occurred in world grain markets which posed a potential threat to the food security of import-dependent developing countries. First, starting in later 1994, real grain prices increased, limiting the ability of less developed countries (LDCs) to import grain during production shortfalls. Second, and perhaps more importantly, after 1993 the world stock-to-use ratios in the major food grains fell to record lows. This paper describes the nature of the 1990s grain price increase, and contrast it to the grain price crisis of the 1970s. The paper looks at 22 of the largest, poorest, and most import-dependent LDCs. The authors conclude that the grain price increase of the 1990s is relatively mild -- certainly relative to the grain price spike of the 1970s -- and does not appear to be indicative of a trend. The study offers some important lessons to be learned from the 1990s grain price increase.
description: "February 1997." Includes bibliographical references (p. 24-25).
Photoproduction of Theta+ on the nucleon and deuteron
Creators: name: Mart, T.
name: Salam, A.
name: Miyagawa, K.
name: Bennhold, C.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Photoproduction of the pentaquark particle Theta^+ on the nucleon has been studied by using an isobar and a Regge model. Using the isobar model, total cross sections around 100 nb for the gamma n --> K- Theta+ channel and 400 nb for the gamma p --> {\bar K}0 Theta+ process are obtained. The inclusion of the K* intermediate state yields a substantially large effect, especially in the gamma p --> {\bar K}0 Theta+ process. The Regge approach predicts smaller cross sections, i.e., less than 100 nb (20 nb) for the process on the neutron (proton). By using an elementary operator from the isobar model, cross sections for the process on a deuteron are predicted.
description: 8 pages, 6 figures, talk given at the International Workshop PENTAQUARK04, July 20-23 at Spring-8, Japan
On the Riemann zeta-function and the divisor problem II
Creators: name: Ivić, Aleksandar
Publisher: name: arXiv
Year: 2004
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11N37, 11M06

description: First part of this paper was published in CEJM (2)(4) (2004), 1-15. It is proved now that $$ \int_0^T|E^*(t)|^5{\rm d}t \ll_εT^{2+ε}. $$ Here $$ E^*(t) = E(t) - 2πΔ^*(t/2π), Δ^*(x) = - Δ(x) +2Δ(2x) - {1\over2}Δ(4x), $$ where $E(t)$ is the error term in the mean square formula for $|ζ(1/2+it)|$ and $Δ(x)$ is the error term in the Dirichlet divisor problem. It is also shown how bounds for moments of $|E^*(t)|$ lead to bounds for moments of $|ζ(1/2+it)|$.
description: 13 pages
ATMO-ACCESS D1.1 Report proposing a common access management concept for atmospheric RIs
Creators: name: Rosa Maria Petracca Altieri
name: Loperte, Simona
name: Dubost, Ariane
Publisher: name: CNR
Year: 2024

description: The document’s delivery was postponed by five months to ensure the collection and processing of sufficient user/provider feedback and thorough consideration of it to establish a robust common access management concept. At the moment of the deliverable, feedback was collected from all users concerned with the 1st Call for Pilot Training TNA and from most users in Calls 1 and 3. Feedback collection is ongoing for the other 5 regular calls and the 5 special calls.The contents and proposed solutions were presented and discussed with the ATMO-ACCESS community in all project meetings as they were developed, and were specifically shared at the 2024 annual meeting in Wuppertal (19-21 March 2024).
Southern Africa: economic structure, trade, and regional integration
Creators: name: Mukherjee, Natasha
name: Robinson, Sherman
name: Mukherjee, Natasha
name: Robinson, Sherman
Publisher: name: Unknown
Year: 1996
Subjects: subject: International Relations/Trade
subject: Southern Africa
subject: Mozambique -- Economic conditions
subject: Social accounting -- Mathematical models
subject: Trade policy -- Africa
subject: Sub-Saharan

description: Many of the countries in the Southern Africa region have very sketchy trade data, due to disruptions in data collection (caused by war in the case of Mozambique and sanctions-induced secrecy in South Africa, for instance) or weak statistical institutions. These trade data are also often in conflict with one another, occasionally even by several orders of magnitude. While much anecdotal information on trade flows exists (especially on newly created trade), it is only now that basic and systematic research on formal trade flows in Southern African is being conducted (e.g. USAID-funded EAGER project and Will Masters at Purdue University, David Evans at University of Sussex, International Food Policy Research Institute's Macroeconomic Reforms and Regional Integration in Southern Africa — MERRISA project). The sparse research agenda on trade issues is a serious problem, in light of Southern Africa's desire for deepened regional integration, improved prospects for economic growth, and equitable development. This paper will present trade (exports and imports, at a 1-digit SITC level, but with maize listed as a separate trade item) data from approximately 20 different sources, both from individual countries and international organizations, for the period 1980-present. The paper will show the major inconsistencies in the trade data between the different data sources. The main contribution of this paper is the reconciliation of the trade data, using a 'cross-entropy' estimation method, to make efficient use of prior information about the structure of trade in the Southern Africa region. The benefit of this approach is that it is very flexible and undemanding in its statistical assumptions, and it allows the use of the trade information in a variety of forms, such as inequality constraints, errors in measurement, and extraneous estimates of various parameters. To date, the cross-entropy method has been applied to the Social Accounting Matrices (SAMs) for the MERRISA countries, including the SAM for Zimbabwe.
description: "October 1996." Includes bibliographical references (leaves 54-55).
Einzelbetrieblicher Umgang mit Dokumentationspflichten im Pflanzenschutz: Eine empirische Erhebung
Creators: name: Battermann, Henning W.
name: Steinmann, Horst-Henning
name: Theuvsen, Ludwig
name: Battermann, Henning W.
name: Steinmann, Horst-Henning
name: Theuvsen, Ludwig
Publisher: name: Unknown
Year: 2008
Subjects: subject: Environmental Economics and Policy
subject: Farm Management
subject: plant protection
subject: good farming practice
subject: Lower Saxony

description: Due to new legislation, contractual commitments and societal demands, the need to document production processes has been growing continuously for farmers. This is particularly so with regard to plant protection. In this study, we surveyed how 581 farmers from Lower Saxony meet the documentation requirements. Almost all farmers surveyed document their plant production including plant protection measures. The most striking differences can be observed with regard to documentation technologies and investments made. Factor and cluster analyses allowed the identification four groups of farmers with different motivations and attitudes towards existing documentation requirements.
Selpercatinib: First Approval
Creators: name: Markham, Anthony
Publisher: name: Adis Journals
Year: 2020
Subjects: Medicine

description: Compliance with Ethical Standards
Funding: The preparation of this review was not supported by any external funding.
Conflict of interest: During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Anthony Markham is a contracted employee of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest.
Additional information about this Adis Drug Review can be found here

AbstractSelpercatinib (RETEVMO™) is a receptor tyrosine kinase RET (rearranged during transfection) inhibitor being developed by Loxo Oncology for the treatment of cancers harbouring RET alterations. Based on results from the phase I/II LIBRETTO-001 trial, selpercatinib was recently approved by the US FDA for the treatment of RET fusion-positive non-small-cell lung cancer, RET fusion-positive thyroid cancer and RET-mutant medullary thyroid cancer. This article summarizes the milestones in the development of selpercatinib leading to this first approval

© Springer Nature Switzerland AG 2020
Disruption of androgen regulation in the prostate by environmental contaminants and dietary factors
Creators: name: Ralph, Jody Love
Publisher: name: University of British Columbia
Year: 2009

description: There is a growing concern that many of the environmental and dietary chemicals, that are ingested by humans but have not been thoroughly tested for endocrine activity, may pose a significant health threat. These chemicals have the potential to mimic or antagonize hormone action through binding to intracellular receptors. This thesis examines the hypothesis that environmental contaminants and dietary factors can influence the function of androgen receptor (AR) in the prostate in a direct manner by binding it, or indirectly through the aryl hydrocarbon receptor (AhR), and thereby may influence prostate development and growth. We have characterized a subclass of androgen response elements in the probasin promoter and we have used a number of methods to investigate known and putative ligands of AhR that may impact androgen receptor function. Our in vitro experimental approach utilizes androgen- and aryl hydrocarbon-responsive DNA constructs connected to a firefly luciferase reporter gene. The degree to which the chemicals bind AR and displace androgen was also evaluated. The results indicate that several AhR ligands, including resveratrol, indole 3 carbinol, curcumin and hexachlorobenzene (HCB) antagonize androgen-initiated transcriptional activity without binding to the androgen receptor. Three AhR ligands have also been tested for in vivo effects using transgenic mice in which the prostate-specific androgen-responsive promoter is linked to a chloramphenicol acetyl transferase (CAT) reporter gene. In four-week-old mice, exposure to either 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) or resveratrol decreased CAT activity and testis weight. In the eight-week-old mice, there was a significant decrease in both CAT activity and prostate weight upon exposure to either HCB or TCDD. Therefore, all three of the AhR ligands studied can suppress androgen-sensitive parameters both in vitro and in vivo. The latest project was designed to investigate the endocrine disrupting properties of 27 environmental compounds identified in an epidemiological study correlating agricultural occupational exposure to increased risk of prostate cancer. Eleven of the compounds bound AR while 22 caused a statistically significant alteration in androgen activity. Environmental contaminants have been implicated in the rising incidence of prostate cancer and insight into the mechanisms of endocrine disruption will clarify their potential role in this disease.
Introducing the DPC Rapid Assessment Model
Creators: name: Mitcham, Jenny
Publisher: name: Zenodo
Year: 2020
Subjects: digital preservation
maturity model
assessment tool

description: The DPC Rapid Assessment Model (RAM) is a digital preservation maturity modelling tool that has been designed to enable rapid benchmarking of an organization’s digital preservation capability. This model aims to be: Applicable for organizations of any size and in any sector Applicable for all content of long-term value Preservation strategy and solution agnostic Based on existing good practice Simple to understand and quick to apply The model used Adrian Brown's Digital Preservation Maturity Model (published in Practical Digital Preservation: a how-to guide for organizations of any size, 2013) as a starting point and has been developed, tested and refined with input from DPC Members and Supporters. It was created in conjunction with the Nuclear Decommissioning Authority as part of a two year collaborative digital preservation project. It was released in September 2019 at the iPRES conference in Amsterdam. The model is designed to be relatively quick and easy to use for any organization charged with preserving digital information for the long term. Some institutions have applied this model in less than one hour but for others it is a longer process, particularly if wider consultation with a range of colleagues is required. DPC RAM has continuous improvement at its core. Although it can be applied as a one-off exercise it is recommended that it is revisited on a more regular basis to highlight progress or demonstrate where further resource or effort is required. It has been designed to provide a rapid assessment of current capabilities so it should not be too onerous a task to apply it on a regular schedule. The poster will draw on some of the highlights of DPC RAM since its release 6 months ago, reflecting on uptake, findings and community feedback collected so far. We are keen to bring DPC RAM to new audiences and discuss with the research data curation community how they could use it internally to discuss digital preservation maturity, highlight gaps and make the case for additional resource.
Ist Geiz wirklich geil? Preis-Qualitäts-Relationen von Hersteller- und Handelsmarken im Lebensmittelmarkt
Creators: name: Schulze, Holger
name: Spiller, Achim
name: Bohm, Justus
name: De Witte, Thomas
name: Schulze, Holger
name: Spiller, Achim
name: Bohm, Justus
name: De Witte, Thomas
Publisher: name: Unknown
Year: 2008
Subjects: subject: Agribusiness
subject: Demand and Price Analysis
subject: Marketing
subject: FOS: Economics and business
subject: price-quality relations
subject: food market
subject: empirical analysis
subject: private labels
subject: discounter

description: Studies which analyze price-quality relations in the consumer goods market are mainly more than ten years old and deal marginally with food products. In this survey, the sceptical findings are confirmed with a special focus on the food market. The results show that food quality, risk avoidance and increase in quality benefits are not determined by price levels. Furthermore, the findings demonstrate that private labels in general – and the private labels of the discounter in particular – have a better price-quality ratio than manufacturer brands and private labels of supermarkets and hypermarkets.
Tunneling splittings of vibrationally excited states using general instanton paths
Creators: name: Eraković, Mihael
name: Cvitaš, Marko T.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A multidimensional semiclassical method for calculating tunneling splittings in vibrationally excited states of molecules using Cartesian coordinates is developed. It is an extension of the theory by Mil'nikov and Nakamura [$\textit{ J. Chem. Phys.}$ $\textbf{122}$, $124311$ $(2005)$] to asymmetric paths that are necessary for calculating tunneling splitting patterns in multi-well systems, such as water clusters. Additionally, new terms are introduced in the description of the semiclassical wavefunction that drastically improve the splitting estimates for certain systems. The method is based on the instanton theory and builds the semiclassical wavefunction of the vibrationally excited states from the ground-state instanton wavefunction along the minimum action path and its harmonic neighborhood. The splittings of excited states are thus obtained at a negligible added numerical effort. The cost is concentrated, as for the ground-state splittings, in the instanton path optimization and the hessian evaluation along the path. The method can thus be applied without modification to many mid-sized molecules in full dimensionality and in combination with on-the-fly evaluation of electronic potentials. The tests were performed on several model potentials and on the water dimer.
description: The following article has been submitted to Journal of Chemical Physics. After it is published, it will be found at https://aip.scitation.org/journal/jcp
Conditional moment closure for methane oxidation using two conditional variables and stochastic processes
Creators: name: Lozada-Ramfrez, Jorges R.
Publisher: name: University of British Columbia
Year: 2009

description: The conditional moment closure method using two conditioning scalar variables is applied to derive the transport equation of species mass fraction, temperature, and scalar dissipation in a decaying, isotropic, homogeneous turbulent methane-air flow. The strain tensor in the transport equation of scalar dissipation of the conditioning variables is simulated using stochastic processes. The results of this model are then compared to DNS and conditional moment closure with one variable for the same test case.
ATMO-ACCESS MS43 Review of application, review and selection process for TNA to ATMO-ACCESS facilities
Creators: name: Petracca Altieri, Rosa Maria
name: Gargano, Giuseppe
name: Gagliardi, Simone
name: CORNACCHIA, CARMELA
name: Ricciardi, Francesca
Publisher: name: CNR
Year: 2022

description: This document is prepared in the context of the ATMO-ACCESS project (Solutions for Sustainable Access to Atmospheric Research Facilities), which represents the organized contribution of distributed atmospheric research facilities for developing a pilot for a new model of Integrating Activities.It describes major reviews, updates, and changes in the access process established in MS 40 after testing in the initial phase.The key changes refer to:▪ The use of the PASS▪ Review of the TNA process▪ Update of the access-related forms and documents
Tunability of the dielectric response of epitaxially strained SrTiO3 from first principles
Creators: name: Antons, Armin
name: Neaton, J. B.
name: Rabe, Karin M.
name: Vanderbilt, David
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The effect of in-plane strain on the nonlinear dielectric properties of SrTiO3 epitaxial thin films is calculated using density-functional theory within the local-density approximation. Motivated by recent experiments, the structure, zone-center phonons, and dielectric properties with and without an external electric field are evaluated for several misfit strains within +-3% of the calculated cubic lattice parameter. In these calculations, the in-plane lattice parameters are fixed, and all remaining structural parameters are permitted to relax. The presence of an external bias is treated approximately by applying a force to each ion proportional to the electric field. After obtaining zero-field ground state structures for various strains, the zone-center phonon frequencies and Born effective charges are computed, yielding the zero-field dielectric response. The dielectric response at finite electric field bias is obtained by computing the field dependence of the structure and polarization using an approximate technique. The results are compared with recent experiments and a previous phenomenological theory. The tunability is found to be strongly dependent on the in-plane lattice parameter, showing markedly different behavior for tensile and compressive strains. Our results are expected to be of use for isolating the role of strain in the tunability of real ultrathin epitaxial films.
description: 11 pages, with postscript figures embedded. Uses REVTEX and epsf macros. Also available at http://www.physics.rutgers.edu/~dhv/preprints/ant_srti/index.html
Fast approximation by periodic kernel-based lattice-point interpolation with application in uncertainty quantification
Creators: name: Kaarnioja, Vesa
name: Kazashi, Yoshihito
name: Kuo, Frances Y.
name: Nobile, Fabio
name: Sloan, Ian H.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: This paper deals with the kernel-based approximation of a multivariate periodic function by interpolation at the points of an integration lattice -- a setting that, as pointed out by Zeng, Leung, Hickernell (MCQMC2004, 2006) and Zeng, Kritzer, Hickernell (Constr. Approx., 2009), allows fast evaluation by fast Fourier transform, so avoiding the need for a linear solver. The main contribution of the paper is the application to the approximation problem for uncertainty quantification of elliptic partial differential equations, with the diffusion coefficient given by a random field that is periodic in the stochastic variables, in the model proposed recently by Kaarnioja, Kuo, Sloan (SIAM J. Numer. Anal., 2020). The paper gives a full error analysis, and full details of the construction of lattices needed to ensure a good (but inevitably not optimal) rate of convergence and an error bound independent of dimension. Numerical experiments support the theory.
description: 37 pages, 5 figures
Hemodynamic Bigger Hydrostatic Pressure Instead of Lower Shear Stress Aggravates Atherosclerosis
Creators: name: Wang, Xinggang
name: Ge, Junbo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Tissues and Organs (q-bio.TO)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The traditional view is that low shear stress of blood flow accelerates atherosclerosis. How does a low shear stress damage the vessel or aggravate atherosclerosis? It is a puzzling question. Furthermore, shear stress of veins is similar to that of Relatively Vulnerable Zones (RVZ) of arteries, while intimal thickening of veins is not obvious as the arteries. There are many places in arterioles with lower shear stress as the decrease of blood velocity, while the thickening of arterioles is not as obvious as that of the medium-sized arteries. These issues make it unconvincing for us to explain atherogenesis with lower shear stress. According to Bernoulli fluid equation (P+1/2\r{ho}v^2+\r{ho}gh=constant), in a closed pipe full of flowing blood, at the same height, the hydrostatic pressure is inversely proportional to the second power of blood velocity. At any point of per unit mass of fluid micro cluster here, the reduction of 1/2\r{ho}v^2 would be converted into P. Therefore, hydrostatic pressure(P) is inversely proportional to v^2 in a very short distance or in the same transection of the artery. When blood micro cluster flows over a very short distance or the same transection of the artery, previous studies did not consider the conversion between 1/2\r{ho}v^2 and P. Therefore, low shear stress aggravates atherosclerosis is an appearance, and the essence is that these areas with smaller blood velocity have much bigger hydrostatic pressure, which aggravates atherosclerosis. This perfectly explains the predisposing sites of atherosclerosis.
description: 6 pages, 1 figure
Audio system: Symptoms, habits, and pressure levels (Almeida et al., 2020)
Creators: name: Almeida, Tamara R.
name: Rocha, Clayton H.
name: Rabelo, Camila M.
name: Gomes, Raquel F.
name: Neves-Lobo, Ivone F.
name: Samelli, Alessandra Giannella
Publisher: name: ASHA journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Health Care
subject: 111712 Health Promotion

description: Purpose: The aims of this study were to characterize hearing symptoms, habits, and sound pressure levels (SPLs) of personal audio system (PAS) used by young adults; estimate the risk of developing hearing loss and assess whether instructions given to users led to behavioral changes; and propose recommendations for PAS users.Method: A cross-sectional study was performed in 50 subjects with normal hearing. Procedures included questionnaire and measurement of PAS SPLs (real ear and manikin) through the users’ own headphones and devices while they listened to four songs. After 1 year, 30 subjects answered questions about their usage habits. For the statistical analysis, one-way analysis of variance, Tukey’s post hoc test, Lin and Spearman coefficients, the chi-square test, and logistic regression were used.Results: Most subjects listened to music every day, usually in noisy environments. Sixty percent of the subjects reported hearing symptoms after using a PAS. Substantial variability in the equivalent music listening level (Leq) was noted (M = 84.7 dBA; min = 65.1 dBA, max = 97.5 dBA). A significant difference was found only in the 4-kHz band when comparing the real-ear and manikin techniques. Based on the Leq, 38% of the individuals exceeded the maximum daily time allowance. Comparison of the subjects according to the maximum allowed daily exposure time revealed a higher number of hearing complaints from people with greater exposure. After 1 year, 43% of the subjects reduced their usage time, and 70% reduced the volume. A volume not exceeding 80% was recommended, and at this volume, the maximum usage time should be 160 min.Conclusions: The habit of listening to music at high intensities on a daily basis seems to cause hearing symptoms, even in individuals with normal hearing. The real-ear and manikin techniques produced similar results. Providing instructions on this topic combined with measuring PAS SPLs may be an appropriate strategy for raising the awareness of people who are at risk.
Supplemental Material S1. Study questionnaire.
Almeida, T. R., Rocha, C. H., Rabelo, C. M., Gomes, R. F., Neves-Lobo, I. F., & Samelli, A. G. (2020). Personal audio system: Hearing symptoms, habits, and sound pressure levels measured in real ear and a manikin. Journal of Speech, Language, and Hearing Research. https://doi.org/10.1044/2020_JSLHR-19-00053
Assessing local action groups and auctions as institutional alternatives for designing and implementing agri-environmental measures in the EU – results from an expert survey
Creators: name: Eggers, Jorg
name: Mettepenningen, Evy
name: Beckmann, Volker
name: Eggers, Jorg
name: Mettepenningen, Evy
name: Beckmann, Volker
Publisher: name: Unknown
Year: 2008
Subjects: subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: Environmental Economics and Policy
subject: Institutional and Behavioral Economics
subject: European agri-environmental policy
subject: decentralisation
subject: local action groups
subject: auctions
subject: European Rural Development Policy
subject: European Agricultural Policy

description: The new European Council Regulation on support for rural development (EC) No. 1698/2005 has opened up the opportunity for two important innovations for the design and implementation of agrienvironmental measures : local action groups (LAG) according to the LEADER approach and calls for tender. The article firstly reviews the political and scientific debate on the possible performance of these innovations and, secondly, analyses how agents in public administrations, private associations and research institutes assess them. This ex-ante evaluation is based on 279 interviews in nine EU member states, carried out in the context of an EU-research project in the Sixth Framework Programme in 2006. The results show that (1) the performance of LAG is generally rated higher than that of auctions, (2) different actors show similar evaluation patterns, thus forming advocacy coalitions, and (3) experiences and learning may play an important role in the actors’ evaluation of both innovations.