cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Poverty and Aspects of Inequality in Australia: An Annotated Bibliography,1963-1987
Creators: name: Encel, Diana
Publisher: name: UNSW Sydney
Year: 1988
Subjects: Social Policy Research Centre
Annotated Bibliography
Poverty
Inequality
Australia

description: This report is the third to appear in the Social Welfare Research Centre's Research Resource Series. It is an annotated bibliography of material published in Australia which relates to poverty and certain aspects of inequality. Concern about poverty in Australia has been increasing since the time of the earliest entries here which cite works published in the early 1960s. That concern has been reflected in the enquiries and reviews established by governments (notably the Poverty Inquiry in 1972 and the Social Security Review in 1986) and in the amount of research undertaken and the number of conferences which have been organised around the theme of poverty in recent years. Research into the economic and social aspects of poverty, including its measurement, causes and consequences is a major focus of the current research agenda of the Centre. So too, is the assessment of government policy in this area and the consideration and analysis of alternative policies. This bibliography draws together the material which has been published in this key area of social policy and should be a useful resource for those whose work continues to focus on the subject.
description: Research Resource Series No 3; No 3
Semaphorin-3A, semaphorin-7A gene single nucleotide polymorphisms, and systemic lupus erythematosus susceptibility
Creators: name: Liu, Li-Na
name: Wang, Peng
name: Zou, Yan-Feng
name: Xu, Zhiwei
name: Cheng, Jian
name: Zhang, Yuzhou
name: Hu, Wenbiao
name: Pan, Hai-Feng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines. Increasing evidence suggest that Sema3A and Sema7A may link to the development and pathogenesis of systemic lupus erythematosus (SLE). Objective: This study aims to evaluate the association of Sema3A, Sema7A gene single-nucleotide polymorphisms (SNPs) with susceptibility to SLE. Methods: There were 495 SLE patients and 493 healthy controls in the study. Sema3A gene and Sema7A gene were genotyped by improved multiple ligase detection reaction (iMLDR), their plasma expression levels were detected by enzyme-linked immunosorbent assay (ELISA). Results: No differences in genotype and allele frequencies of these SNPs were observed between SLE patients and healthy controls. However, analysing Sema3A and Sema7A SNPs with clinical manifestations of SLE indicated that, in Sema3A, the A allele frequencies of rs7804122 polymorphism was higher in patients with oral ulcers. In Sema7A, there were differences in allele frequencies of the rs2075589 and rs28362930 polymorphisms between SLE patients with haematological disorder and those without. The GG genotype and G allele frequencies of rs28362930 and the CC genotype, and C allele frequencies of rs741761 were both related to discoid rash in SLE patients. The allele frequency of G (rs28362930) was higher in SLE patients with renal disorder. There were differences in the genotype frequencies and allele frequencies of rs741761 between SLE patients with and without arthritis. No differences in plasma Sema3A and Sema7A levels were detected in SLE patients of different genotypes. Conclusions:Sema3A and Sema7A gene polymorphisms are not related to SLE genetic susceptibility, but may link to several clinical features of SLE.
A computational study to identify the key residues of peroxisome proliferator-activated receptor gamma in the interactions with its antagonists
Creators: name: Tayebeh Sharifi
name: Ghayeb, Yousef
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Peroxisome proliferator-activated receptors (PPARs) compose a family of nuclear receptors, PPARα, PPARβ, and PPARγ, which mediate the effects of lipidic ligands at the transcriptional level. Among these, the PPARγ has been known to regulate adipocyte differentiation, fatty acid storage and glucose metabolism, and is a target of antidiabetic drugs. In this work, the interactions between PPARγ and its six known antagonists were investigated using computational methods such as molecular docking, molecular dynamics (MD) simulations, and the hybrid quantum mechanics/molecular mechanics (QM/MM). The binding energies evaluated by molecular docking varied between −22.59 and −35.15 kJ mol− 1. In addition, MD simulations were performed to investigate the binding modes and PPARγ conformational changes upon binding of antagonists. Analysis of the root-mean-square fluctuations (RMSF) of backbone atoms shows that H3 of PPARγ has a higher mobility in the absence of antagonists and moderate conformational changes were observed. The interaction energies between antagonists and each PPARγ residue involved in the interactions were studied by QM/MM calculations. These calculations reveal that antagonists with different structures show different interaction energies with the same residue of PPARγ. Therefore, it can be concluded that the key residues vary depending on the structure of the ligand, which binds to PPARγ.
Molecular dynamics simulations of apo and holo forms of fatty acid binding protein 5 and cellular retinoic acid binding protein II reveal highly mobile protein, retinoic acid ligand, and water molecules
Creators: name: Hunter, Nathanael H.
name: Bakula, Blair C.
name: Bruce, Chrystal D.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Structural and dynamic properties from a series of 300 ns molecular dynamics, MD, simulations of two intracellular lipid binding proteins, iLBPs, (Fatty Acid Binding Protein 5, FABP5, and Cellular Retinoic Acid Binding Protein II, CRABP-II) in both the apo form and when bound with retinoic acid reveal a high degree of protein and ligand flexibility. The ratio of FABP5 to CRABP-II in a cell may determine whether it undergoes natural apoptosis or unrestricted cell growth in the presence of retinoic acid. As a result, FABP5 is a promising target for cancer therapy. The MD simulations presented here reveal distinct differences in the two proteins and provide insight into the binding mechanism. CRABP-II is a much larger, more flexible protein that closes upon ligand binding, where FABP5 transitions to an open state in the holo form. The traditional understanding obtained from crystal structures of the gap between two β-sheets of the β-barrel common to iLBPs and the α-helix cap that forms the portal to the binding pocket is insufficient for describing protein conformation (open vs. closed) or ligand entry and exit. When the high degree of mobility between multiple conformations of both the ligand and protein are examined via MD simulation, a new mode of ligand motion that improves understanding of binding dynamics is revealed.
Valorization of potato peel: a biorefinery approach
Creators: name: Pranav D. Pathak
name: Mandavgane, Sachin A.
name: Puranik, Nikhil Manoj
name: Swapnil Jaygopal Jambhulkar
name: Kulkarni, Bhaskar D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology
subject: Plant Biology

description: Potato is the fourth main crop consumed worldwide and is an important constituent in the human diet. Consequently, potato is widely used in food-processing industries. However, these industries generate massive amounts of potato peel (PP) as a by-product, which is usually considered a waste, and is discarded. Interestingly, recent research suggests that PP is a valuable source of bioactive compounds, which can be converted into value-added products. In this study, we review the physicochemical composition and valorization of PP. In addition to being used as a dietary fiber or medicine, the value-added products obtained by the fermentation of PP have multiple uses, including their use as adsorbents, biocomposites and packaging materials. These products can also be used in energy production, biopolymer film development, corrosion inhibition and the synthesis of cellulose nanocrystals. The biorefinery approach for PP will increase the value of this waste by producing an array of value-added products and reducing extensive waste generation.
A nutritional intervention programme at a worksite canteen to promote a healthful lifestyle inspired by the traditional Mediterranean diet
Creators: name: Vitale, Marilena
name: Bianchi, Marta A.
name: Rapetti, Valeria
name: Pepe, Josè M.
name: Giacco, Angela
name: Giacco, Rosalba
name: Riccardi, Gabriele
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: This study investigates the effectiveness and long-term impact on the composition of the habitual diet of a nutritional intervention programme – undertaken through panels, totems, and table mats or handout leaflets – based on the promotion at a worksite canteen of healthy food-choices resembling the traditional Mediterranean diet. A significantly higher choice of dishes based on wholegrain cereals, legumes, white meat and fish, and a lower choice of dishes based on refined cereals, red and processed meat, eggs and cheese was observed at the end of the intervention and after six months and three years of follow-ups. A significantly better adherence to the nutritional recommendations for saturated-fat, cholesterol, sugars and fibre was observed. This study reveals that a nutritional intervention programme promoting the traditional Mediterranean diet and utilising a minimally intensive approach is feasible and effective to modify in a beneficial way the dietary habits of a working population and keep these changes in the long-term.
Mobiliário litúrgico pétreo no contexto do barroco português: tipologias e funcionalidades
Creators: name: Coutinho, Maria João Pereira
Publisher: name: Revista de Artes Decorativas
Year: 2012

description: O presente estudo, que trata de mobiliário religioso português do período barroco, centra-se em objectos que estiveram ao serviço da liturgia, como credências, lavabos, mesas ou bofetes, púlpitos e teias. A visão lançada sobre estes exemplos, neste caso realizados em materiais pétreos, procura dar a conhecer alguns dos equipamentos que faziam parte do cerimonial eucarístico, como os da purificação do sacerdote, os que suportavam alfaias, os que albergavam o pregador e aqueles que dividiam o espaço cultual. Como já tivemos oportunidade de notar em outros trabalhos, o recurso à pedra e o facto de exibirem determinadas características formais, coloca estes objectos no contexto da produção barroca portuguesa.
description: Revista de Artes Decorativas, n. 6 (2012)
Zero-inflated models and estimation in zero-inflated Poisson distribution
Creators: name: Wagh, Yogita S.
name: Kirtee K. Kamalja
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In this paper, we briefly overview different zero-inflated probability distributions. We compare the performance of the estimates of Poisson, Generalized Poisson, ZIP, ZIGP and ZINB models through Mean square error (MSE), bias and Standard error (SE) when the samples are generated from ZIP distribution. We propose a new estimator referred to as probability estimator (PE) of inflation parameter of ZIP distribution based on moment estimator (ME) of the mean parameter and compare its performance with ME and maximum likelihood estimator (MLE) through a simulation study. We use the PE along with ME and MLE to fit ZIP distribution to various zero-inflated datasets and observe that the results do not differ significantly. We recommend using PE in place of MLE since it is easy to calculate and the simulation study in this paper demonstrates that the PE performs as good as MLE irrespective of the sample size.
Additional file 13 of Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
Creators: name: Jing, Yipei
name: Jiang, Xueke
name: Lei, Li
name: Peng, Meixi
name: Ren, Jun
name: Xiao, Qiaoling
name: Tao, Yao
name: Tao, Yonghong
name: Huang, Junpeng
name: Wang, Lu
name: Tang, Yuting
name: Yang, Zailin
name: Yang, Zesong
name: Zhang, Ling
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 13 : Figure S8. HOTAIRM1 promotes autophagy and proliferation in transfected OCI-AML2 + NPM1-mA leukemia cells. a, i Western blot analysis of LC3-II and p62 levels in OCI-AML2 + NPM1-mA cells after transfection of shHOTAIRM1 (a) and HOTAIRM1 expression vector (i). b, j Representative microscopy images of LC3 puncta in HOTAIRM1-silenced OCI-AML2 + NPM1-mA (b) and HOTAIRM1-enforced OCI-AML2 + NPM1-mA (j). The bar graphs showed the quantification of the fluorescent puncta data. Scale bar: 25 μm. c, k Evaluation of cell viability in OCI-AML2 + NPM1-mA cells transfected with shHOTAIRM1 (c) or HOTAIRM1 plasmid (k) for indicated by CCK-8 assays. d, l Evaluation of cell proliferation in HOTAIRM1-silenced (d) and HOTAIRM1-enforced OCI-AML + NPM1-mA cells (l) for indicated by EdU assays. The bar graphs showed the percentage of EdU positive cells. Scale bar: 100 μm. e, m Flow cytometry was performed to assess cell cycle of HOTAIRM1-silenced (e) and HOTAIRM1-enforced OCI-AML2 + NPM1-mA cells (m). The bar graph shows the percentages of G0/G1-, S-, and G2/M-phase cells. f, n Flow cytometry was used to detect apoptosis of HOTAIRM1-silenced (f) and HOTAIRM1-enforced OCI-AML2 + NPM1-mA cells (n). LL, dead cells; UL, viable cells; LR, early apoptotic cells; UR, late apoptotic cells. g, o Flow cytometric analysis was performed to analyze apoptosis of OCI-AML2 + NPM1-mA cells after transfection with shHOTAIRM1 (g) or HOTAIRM1 plasmid (o), followed by treatment with 200 nM Ara-C for 48 h. h, p The protein levels of Cyclin D1, CDK4, Bax and Bcl-2 in HOweTAIRM1-silenced (h) and HOTAIRM1-enforced OCI-AML2 + NPM1-mA cells (p). The data are presented as the mean ± SD of three independent experiments. **P < 0.01, ***P < 0.001. n.s. indicates no significant difference.
Benchmarks and Other Approaches to Planning Community Support Services: An Annotated Bibliography
Creators: name: Sitsky, Lynn
Publisher: name: UNSW Sydney
Year: 1991
Subjects: Annotated Bibliography
Community Support Services

description: This bibliography is published as part of a study funded by a Research and Development Grant from the Commonwealth Department of Community Services and Health in 1989. It complements the final report of this study published as SPRC Reports and Proceedings No. 94, 1991, Benchmarks and Other Approaches to Planning Community Support Services: A Review of International Experience, by Michael Fine and Sara Graham with Adrian Webb. The broad aims of this study were to examine and critically appraise existing methodologies for the planning of community services to older, frail people, people with disabilities and the carers of both groups; to clarify conceptual issues; to examine the feasibility of implementing national planning guidelines in the light of international experience; and to develop recommendations for establishing and costing the guidelines on a national basis. Material for this study, and hence the bibliography, was obtained in a number of ways. An on-line bibliographic search was undertaken in July 1989, with an update in September 1990. Relevant government departments and research institutions in 22 countries were contacted with requests for information on their planning methods. Personal contact was made with people working in the area of community service planning. In August 1989 a number of interviews were conducted with personnel involved in the planning and delivery of services in the United Kingdom at all levels of government, with the voluntary sector, and with academics. In September 1990, to update information received earlier, a questionnaire was sent to the relevant government departments of the 22 countries which sought information on the scope of their services, the existence of benchmarks or planning formulae, and on the problems and issues associated with the planning and delivery of services in their countries.
description: Research Resource Series; No 8
Foster Carers in New South Wales: profile and projections based on ABS Census data
Creators: name: Siminski, Peter
name: Chalmers, Jenny
name: McHugh, Marilyn
Publisher: name: UNSW Sydney
Year: 2005

description: Administrative data on foster carers in New South Wales (NSW) are sadly lacking. Based on research commissioned by the NSW Department of Community Services, this paper uses the Australian Bureau of Statistics Census of Population and Housing and other data to provide up to date information on the characteristics of foster carers and the demographic trends that are influencing their numbers. Census data indicate that foster carer families are most likely to contain women aged 35-54 years, not in the labour force. Couples account for two thirds of all foster carers, with the majority of those couples also caring for birth children. While single parents account for less than one-fifth of all foster carers, they are more likely to foster than couples, either with or without birth children. Higher rates of fostering were found in relatively disadvantaged areas. Projected increases in female labour force participation are expected to contribute to a decline (or to slower growth) in the number of foster carers over the next decade. However, projected increases in sole parent families and couples without children are expected to have the opposite effect. The relative magnitude of these effects was not ascertained.
description: SPRC Discussion Paper; 139
A nutritional intervention programme at a worksite canteen to promote a healthful inspired by the traditional Mediterranean diet
Creators: name: Vitale, Marilena
name: Bianchi, Marta A.
name: Rapetti, Valeria
name: Pepe, Josè M.
name: Giacco, Angela
name: Giacco, Rosalba
name: Riccardi, Gabriele
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: This study investigates the effectiveness and long-term impact on the composition of the habitual diet of a nutritional intervention programme – undertaken through panels, totems, and table mats or handout leaflets – based on the promotion at a worksite canteen of healthy food-choices resembling the traditional Mediterranean diet. A significantly higher choice of dishes based on wholegrain cereals, legumes, white meat and fish, and a lower choice of dishes based on refined cereals, red and processed meat, eggs and cheese was observed at the end of the intervention and after six months and three years of follow-ups. A significantly better adherence to the nutritional recommendations for saturated-fat, cholesterol, sugars and fibre was observed. This study reveals that a nutritional intervention programme promoting the traditional Mediterranean diet and utilising a minimally intensive approach is feasible and effective to modify in a beneficial way the dietary habits of a working population and keep these changes in the long-term.
title: Design for decision making: the design of information for later life housing options
Creators: name: Warner, Rachel
Publisher: name: University of Reading
Year: 2021

description: This research explores the visual presentation of information for UK later life housing options provided by third sector organisations. The aim is to understand how design and design practice contribute to the effective provision of information that supports decision-making activities. Discussed below are the research approach and techniques used, recommendations for design practice, and avenues for further enquiry. A layered and pragmatic research approach is used, including analysis of the visual organisation of housing options documents and discussions with users about perceptions of existing documents. Design practice, in relation to such documents, is considered through interviews with trained designers and document producers working in the third sector. The techniques used to describe document design and elucidate design practice include: tree diagrams, tables, document thumbnails, and colour coding to unpack graphic features; visual prompts to encourage discussion of design practice; paper and digital techniques to organise interview data; and spatial arrangements and colour coding in charts to communicate collated findings. The development of a framework to direct thinking towards document design also aided familiarisation with the multi-disciplinary domain of later life housing. The research approach taken confirms the value of synthesising multiple perspectives so that the following recommendations can be better implemented within real-world design practice: using visual rhetoric appropriate for impartial content, to facilitate document use and perceived value; developing design resources to visually differentiate documents and a library of graphic features that facilitate decision-making activities; evaluating the comparative affordances of print and digital documents for decision making; and recognising the importance of image choice. The techniques used also have implications for design practitioners and researchers aiming to elucidate design practices within multi-disciplinary domains, and have pedagogical value for conducting visual analyses of documents. The findings also have implications for the management of design projects in the domain of later life housing, including financial considerations impacting third sector design practice, the integral role of design briefs in collaborative projects, and the involvement of users. Areas for further research identified include the development of ‘conversation starter’ documents for later life housing, participant studies exploring how visually differentiating documents can alleviate perceptions of information overload, and the application of findings to other real-world domains, such as Power of Attorney, that deal with later life and decision making
Additional file 4: of Confirmation of Fusarium root rot resistance QTL Fsp-Ps 2.1 of pea under controlled conditions
Creators: name: Coyne, Clarice
name: Porter, Lyndon
name: Boutet, Gilles
name: Ma, Yu
name: McGee, Rebecca
name: Lesné, Angélique
name: Baranger, Alain
name: Pilet-Nayel, Marie-Laure
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Astronomical and Space Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology

description: Linkage map and QTLs. Black box ±1 LOD and line bars ±2 LOD from peak. (PDF 719 kb)
EFECTIVIDAD DE TRES TÉCNICAS UTILIZADAS EN LA TOMA DE MUESTRA PARA BIOPSIA  EN EL DIAGNÓSTICO HISTOLÓGICO DE LESIONES DEL TRACTO GENITAL INFERIOR
Creators: name: Ajakaida, Renaud
Publisher: name: Zenodo
Year: 2024

description: Las lesiones del tracto genital inferior incluyen, lesiones benignas o premalignas que afectan la vulva, vagina, cuello del útero y área del periné. Existen diferentes técnicas de incisión para biopsia con fines de efectuar un diagnóstico de las lesiones del tracto genital inferior. En este estudio de corte transversal, se analizó la efectividad de las técnicas utilizadas en la toma de muestra para biopsia en el diagnóstico histológico de dichas lesiones, en 95 mujeres sometidas a escisión con asa diatérmica, bisturí frío o láser diodo 960w, que acudieron a la consulta ginecológica durante un año. Se halló que la región anatómica del cuello uterino fue la de mayor número de muestras tomadas (84,2%) y el método de escisión predominante para la toma de muestra predominantes fue con bisturí en frio (52,6 %).  La patología más común por región anatómicas fue en el cuello uterino el LIE-BG (46,2 %). Solo se evidenció daño de los bordes con la técnica de asa diatérmica (32,0 %); mientras que con el uso de bisturí en frío y láser diodo 960w no se evidenció daño térmico. Se concluyó, de las tres técnicas estudiadas, el láser diodo 960w, no presentó errores de diagnóstico causados por el daño térmico en sus bordes. El margen de uso del láser de diodo 960w es más preciso en comparación con el de otros sistemas. El daño térmico puede ser controlado y reducido, alternando el uso de ajustes de potencia, pulso y tasa de repetición. 

Lower genital tract injuries include benign or premalignant lesions affecting the vulva, vagina, cervix and perineal area. There are different incision techniques for biopsy to make a diagnosis of lower genital tract lesions. In this cross-sectional study, the effectiveness of the techniques used in sampling for biopsy in the histological diagnosis of such lesions was analyzed in 95 women undergoing excision with loop diathermy, cold scalpel or 960w diode laser, who attended the gynecological consultation during one year. It was found that the cervical anatomical region had the highest number of samples taken (84.2%) and the predominant cleavage method for taking predominant samples was with cold scalpel (52.6%). The most common pathology by anatomical region in the cervix was LSIL (46.2%). Only thermal damage to the edges was evidenced with the loop diathermy technique (32.0%); while with the use of cold scalpel and 960w diode laser, no thermal damage was evidenced. It was concluded that of the three techniques studied, the 960w diode laser did not present diagnostic errors caused by thermal damage to its edges. The margin of use of the 960 w diode laser is more precise compared to other systems. Thermal damage can be controlled and reduced by alternating the use of power, pulse and repetition rate settings.
O retábulo da capela de Nossa Senhora do Desterro, em Granja Nova – Tarouca
Creators: name: Cardoso, Pedro Vasconcelos
Publisher: name: Revista de Artes Decorativas
Year: 2012

description: A instituição de capelas particulares ligadas ao tema do Desterro pode resultar de uma maior influência da Ordem de Cister nas famílias que as erigiram. A sua construção era também um símbolo de afirmação local por parte da sua nobreza, ou fidalguia. O cuidado posto na execução dos altares de talha desses edifícios, demonstram a vontade de enobrecer os seus espaços e a fé que preconizavam com a salvação das suas almas. O que o retábulo da capela de Nossa Senhora do Desterro, Granja Nova, Tarouca, demonstra é uma aproximação intencional aos valores de maior erudição da arte dessa época, inspirando-se nas fontes que chegavam a Portugal provenientes de dois dos mais importantes centros artísticos da Europa de então – a Flandres e Itália.
description: Revista de Artes Decorativas, n. 6 (2012)
Income Sharing Between Parents and Young People Living at Home
Creators: name: Schneider, Judy
Publisher: name: UNSW Sydney
Year: 2003

description: Since the 1970s, changes in the Australian labour market, education and income policies have led to reductions in income for young people aged 15 to 24 years. Young people today are therefore more reliant on their parents sharing income with them. This paper presents the results of original research that shows how parents share, or ‘pool’ their income with young people living at home. Australian household expenditure data is examined using new and extended methods to show how different levels of income received by young people and their parents affects expenditure on themselves and other family members. It is found that on average, young peoples’ consumption of basic food items is unaffected by their level of personal income indicating that parents pool income for these items. However, in low-income families, young people are more likely to consume luxury food items if they have higher personal incomes suggesting less pooling by parents. It is also found that regardless of levels of parental income, young peoples’ consumption of adult goods such as alcohol and cars is restricted unless they have incomes of their own.
description: SPRC Discussion Paper; 124
Towards a National Aviation Policy Statement
Creators: name: Freestone, Robert
name: Foster, Kym
name: Williams, Peter
Publisher: name: UNSW Sydney
Year: 2008

description: This submission to the Department of Infrastructure, Transport, Regional Development and Local Government (DITRDLG) relates to Section 2.1 of the Discussion Paper on Airport Planning and Development. It is concerned with airport area development and governance issues, rather than more explicitly environmental issues (noise, OLS etc) although these are vital related concerns and together need integrated treatment. This submission was prepared by Robert Freestone, Kym Foster, and Peter Williams for the City Futures Research Centre in Faculty of the Built Environment at the University of New South Wales. Robert Freestone is Professor and Peter Williams is Senior Lecturer in Planning and Urban Development at UNSW. Kym Foster is an APAI PhD Student in the Faculty and former senior head for policy and coordination in aviation and airports for DOTARS. The authors are connected to the broader Airport Metropolis Research Project (Australian Research Council LP0775225) being managed by the Queensland University of Technology (under Chief Investigator Associate Professor Douglas Baker, School of Urban Development, QUT). This submission complements the more wide-ranging submission made by QUT on the Issues Paper in relation to airport planning and development.
description: City Futures Research Centre Issues Paper No. 5
Molecular dynamics simulations of apo and holo forms of fatty acid binding protein 5 and cellular retinoic acid binding protein II reveal highly mobile protein, retinoic acid ligand, and water molecules
Creators: name: Hunter, Nathanael H.
name: Bakula, Blair C.
name: Bruce, Chrystal D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Structural and dynamic properties from a series of 300 ns molecular dynamics, MD, simulations of two intracellular lipid binding proteins, iLBPs, (Fatty Acid Binding Protein 5, FABP5, and Cellular Retinoic Acid Binding Protein II, CRABP-II) in both the apo form and when bound with retinoic acid reveal a high degree of protein and ligand flexibility. The ratio of FABP5 to CRABP-II in a cell may determine whether it undergoes natural apoptosis or unrestricted cell growth in the presence of retinoic acid. As a result, FABP5 is a promising target for cancer therapy. The MD simulations presented here reveal distinct differences in the two proteins and provide insight into the binding mechanism. CRABP-II is a much larger, more flexible protein that closes upon ligand binding, where FABP5 transitions to an open state in the holo form. The traditional understanding obtained from crystal structures of the gap between two β-sheets of the β-barrel common to iLBPs and the α-helix cap that forms the portal to the binding pocket is insufficient for describing protein conformation (open vs. closed) or ligand entry and exit. When the high degree of mobility between multiple conformations of both the ligand and protein are examined via MD simulation, a new mode of ligand motion that improves understanding of binding dynamics is revealed.
The costs of disability and the incidence of poverty
Creators: name: Saunders, Peter
Publisher: name: UNSW Sydney
Year: 2006

description: Although both disability and poverty have been subjected to extensive research, relatively few Australian studies have examined the relationship between these two important social issues. However, recent changes to the Disability Support Pension mean that there is an urgent need to estimate the costs of disability so that the impact of the changes on poverty can be assessed and inserted into the policy debate. This paper reviews evidence linking the presence of disability to the risk of poverty and the actual hardship using data from the 1998-99 Household Expenditure Survey (HES), and shows that where there is someone in the household with a disability, poverty rates are higher and hardship is more prevalent. It then uses the HES data to estimate the costs of disability using a method recently developed in the UK that relies upon information on household living standards. The estimates are robust and reliable, indicating that the costs of disability represent a substantial percentage of disposable income, and thus that poverty rates are much higher where there is a disability present. Estimates based on the impact of the severity of the restriction associated with the disability are also derived and make a similarly large difference to conventional poverty estimates. Overall, the estimates imply that there is an urgent need to review the adequacy of income support arrangements for those with a disability across all household types: single and married; young and old; one- and two-parent; with and without children. The size of the impact of disability on the risk of poverty and actual hardship suggests that action is required to ensure that people with a disability no longer have to confront a greatly increased risk of poverty in addition to many other challenges.
description: SPRC Discussion Paper; 147
Additional file 14 of Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
Creators: name: Jing, Yipei
name: Jiang, Xueke
name: Lei, Li
name: Peng, Meixi
name: Ren, Jun
name: Xiao, Qiaoling
name: Tao, Yao
name: Tao, Yonghong
name: Huang, Junpeng
name: Wang, Lu
name: Tang, Yuting
name: Yang, Zailin
name: Yang, Zesong
name: Zhang, Ling
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 14 : Figure S9. HOTAIRM1 promotes autophagy and proliferation in transfected OCI-AML2 leukemia cells. a Western blot analysis of LC3-II and p62 levels in OCI-AML2 cells after transfection of HOTAIRM1 expression vector. b Representative microscopy images of LC3 puncta in HOTAIRM1-enforced OCI-AML2 cells. The bar graphs showed the quantification of the fluorescent puncta data. Scale bar: 25 μm. c Evaluation of cell viability in OCI-AML2 cells transfected with HOTAIRM1 plasmid for indicated by CCK-8 assays. d Evaluation of cell proliferation in HOTAIRM1-enforced OCI-AML2 cells for indicated by EdU assays. The bar graphs showed the percentage of EdU positive cells. Scale bar: 100 μm. e Flow cytometry was performed to assess cell cycle of HOTAIRM1-enforced OCI-AML2 cells. The bar graph shows the percentages of G0/G1-, S-, and G2/M-phase cells. f Flow cytometry was used to detect apoptosis of HOTAIRM1-enforced OCI-AML2 cells. LL, dead cells; UL, viable cells; LR, early apoptotic cells; UR, late apoptotic cells. g The protein levels of Cyclin D1, CDK4, Bax and Bcl-2 in HOTAIRM1-enforced OCI-AML2 cells. The data are presented as the mean ± SD of three independent experiments. **P < 0.01, ***P < 0.001. n.s. indicates no significant difference.
A prataria religiosa espanhola em Portugal como veículo de mensagem: 1580-1640
Creators: name: Grancho, Nuno Cruz
Publisher: name: Revista de Artes Decorativas
Year: 2012

description: A ourivesaria religiosa sempre se socorreu da palavra, para melhor estabelecer uma relação que se pretendia catequizadora junto dos fiéis, podendo assumir-se, simultaneamente, como via de afirmação de poder por parte dos seus detentores. A análise das relações compreendidas entre a palavra e a imagem permite trazer à investigação, pequenas informações que quando aprofundadas, possibilitam aos historiadores de arte eventuais percursos valorativos da mesma. Foi com base nesse inquestionável interesse detido por tais apontamentos e, reunindo o presente conjunto de peças de ourivesaria da prata religiosa, existentes em Portugal Continental, de origem espanhola e balizadas entre 1580 e 1640, que desenvolvemos diálogos próprios com cada um dos espécimes, originando interpretações que apresentamos seguidamente, no desenvolvimento deste estudo.
description: Revista de Artes Decorativas, n. 6 (2012)
International Competitiveness and the Welfare State: A Case Study of the United Kingdom
Creators: name: Gough, Ian
Publisher: name: UNSW Sydney
Year: 1990
Subjects: International Competitiveness
Welfare State
United Kingdom

description: This Report was written as part of a comparative study of international competitiveness and welfare statism in five countries. In addition to the United Kingdom, the broader study includes France, Germany, Sweden and the United States. The case study of the United Kingdom discussed in this Report takes as its focus and point of departure the experiences of the United Kingdom during the 1980s under the policies of Mrs Thatcher, policies associated with what is referred to in Australia as 'economic rationalism' and 'the new right'. While there are differences between the economic and social policies introduced by the Thatcher Government and those pursued in Australia in the last decade, there are similarities too, reflecting similarities in the economic problems confronting the two nations, as well as the broad policy framework adopted. There can be few in Australia, whatever their political persuasion, who would doubt that the two main themes of this Report. International Competitiveness and the Welfare State, lie at the heart of this country's economic and social difficulties. For this reason alone, we in Australia have much to gain from a better understanding of the United Kingdom experience. And when that experience is analysed by such an insightful and provocative writer as Ian Gough, the benefits are all that much greater. The report is organised in four main chapters, considering in turn: British policy debates on international competitiveness; Trends in the competitiveness of the UK economy; Developments in economic policy; and, Changes in 'welfare statism' - British social policies and their outcomes. It covers the period since the beginning of the international crisis in 1973, but its main focus is on the 'Thatcher Experiment’ since 1979.
description: Reports and Proceedings; 85
Zero-Inflated models and estimation in Zero-Inflated Poisson distribution
Creators: name: S. Wagh Yogita
name: K. Kamalja Kirtee
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In this paper, we briefly overview different zero-inflated probability distributions. We compare the performance of the estimates of Poisson, Generalized Poisson, ZIP, ZIGP and ZINB models through Mean square error (MSE), bias and Standard error (SE) when the samples are generated from ZIP distribution. We propose a new estimator referred to as probability estimator (PE) of inflation parameter of ZIP distribution based on moment estimator (ME) of the mean parameter and compare its performance with ME and maximum likelihood estimator (MLE) through a simulation study. We use the PE along with ME and MLE to fit ZIP distribution to various zero-inflated datasets and observe that the results do not differ significantly. We recommend using PE in place of MLE since it is easy to calculate and the simulation study in this paper demonstrates that the PE performs as good as MLE irrespective of the sample size.
Additional file 1: of Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study
Creators: name: Zhao, Jie
name: Schooling, C.
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Table S1. Characteristics of all genome-wide significant genetic predictors for linoleic acid (LA). (DOCX 64 kb)
Biodegradation of phenol and benzene by endophytic bacterial strains isolated from refinery wastewater-fed Cannabis sativa
Creators: name: Aneela Iqbal
name: Arshad, Muhammad
name: Hashmi, Imran
name: Raghupathy Karthikeyan
name: Gentry, Terry J.
name: Schwab, Arthur Paul
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: The presence of benzene and phenol in the environment can lead to serious health effects in humans and warrant development of efficient cleanup strategies. The aim of the present work was to assess the potential of indigenous endophytic bacterial strains to degrade benzene and phenol. Seven strains were successfully isolated from Cannabis sativa plants irrigated with oil refinery wastewater. Molecular characterization was performed by 16S rRNA gene sequencing. Phenol was biodegraded almost completely with Achromobacter sp. (AIEB-7), Pseudomonas sp. (AIEB-4), and Alcaligenes sp. (AIEB-6) at 250, 500, and 750 mg L−1; however, the degradation was only 81%, 72%, and 69%, respectively, when exposed to 1000 mg L−1. Bacillus sp. (AIEB-1), Enterobacter sp. (AIEB-3), and Acinetobacter sp. (AIEB-2) degraded benzene significantly at 250, 500, and 750 mg L−1. However, these strains showed 80%, 72%, and 68% benzene removal at 1000 mg L−1 exposure, respectively. Rates of degradation could be modeled with first-order kinetics with rate constant values of 1.86 × 10−2 for Pseudomonas sp. (AIEB-4) and 1.80 × 10−2 h−1 for Bacillus sp. (AIEB-1) and half-lives of 1.5 and 1.6 days, respectively. These results establish a foundation for further testing of the phytoremediation of hydrocarbon-contaminated soils in the presence of these endophytic bacteria.
Validity and power of minimization algorithm in longitudinal analysis of clinical trials
Creators: name: Weng, Hua
name: Bateman, Randall
name: Morris, John C.
name: Chengjie Xiong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: We studied the validity of longitudinal statistical inferences of clinical trials using minimization, a dynamic randomization algorithm, designed to minimize treatment imbalance for prognostic factors. Repeated measures analysis of covariance and the random intercept and slope models were used to simulate longitudinal clinical trials randomized by minimization or simple randomization. The simulations represented a wide range of analyses in real-world trials, including missing data caused by dropouts, unequal allocation of treatment arms, and efficacy analyses on either the original outcome or its change from baseline. We also analyzed the database from the Dominantly Inherited Alzheimer Network (DIAN), and used the estimated parameters to simulate the ongoing DIAN trial. Our analyses demonstrated minimization had conservative type I errors when the prognostic factor used in the minimization algorithm had a relatively strong correlation with the outcome and was not adjusted for in analyses. In contrast, adjusted tests for the prognostic factor as a covariate resulted in type I errors close to the nominal significance level. In many simulation scenarios, the adjusted tests using minimization had slightly greater statistical power than those using simple randomization, whereas in the other scenarios, the power of adjusted tests using these two randomization methods are almost indistinguishable.
Additional file 15 of Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
Creators: name: Jing, Yipei
name: Jiang, Xueke
name: Lei, Li
name: Peng, Meixi
name: Ren, Jun
name: Xiao, Qiaoling
name: Tao, Yao
name: Tao, Yonghong
name: Huang, Junpeng
name: Wang, Lu
name: Tang, Yuting
name: Yang, Zailin
name: Yang, Zesong
name: Zhang, Ling
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 15 : Figure S10. HOTAIRM1 expression in HOTAIRM1-silenced OCI-AML3 cells transfected with different vectors.