cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Φυτοχημική Ανάλυση των μη πτητικών συστατικών του ενδημικού είδους Origanum dictamnus L.
Creators: name: Παλουκοπούλου, Χαρίκλεια Αναστασίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2019
Subjects: Φυτοχημική Ανάλυση
Μη πτητικά συστατικά
Phytochemical Analysis
Non-volatile components
Origanum dictamnus L.

description: Σκοπός της διατριβής ήταν η φυτοχημική ανάλυση των μη πτητικών συστατικών του ενδημικού είδους Origanum dictamnus L. Ο Δίκταμος, είναι ένα ελληνικό φαρμακευτικό φυτό, το οποίο καλλιεργείται εκτεταμένα στην Ελλάδα, ενώ η πρόσφατη μονογραφία του Ευρωπαϊκού Οργανισμού Φαρμάκων ευνοεί την περαιτέρω αξιοποίηση αυτού. Μελετήθηκαν δύο εκχυλίσματα το κυκλοεξανικό, το οποίο περιείχε τα πολύ άπολα συστατικά, και το υδατικό, το οποίο περιείχε ιδιαιτέρως πολικά μόρια. Με τη βοήθεια κλασσικών χρωματογραφικών μεθόδων, όπως χρωματογραφία υπό κενό (VLC), χρωματογραφία στήλης (Silica, Sephadex L-20, Amberlite) και υγρή χρωματογραφία υψηλής απόδοσης (HPLC), απομονώθηκαν συνολικά δεκατρείς ενώσεις. Οι δευτερογενείς μεταβολίτες που απομονώθηκαν ανήκουν σε διαφορετικές φυτοχημικές ομάδες: τερπένια, φαινολικά οξέα, φλαβονοειδή και αλεϊκυκλικά παράγωγα. Μεταξύ των ενώσεων απομονώθηκε και ένα διμερές της καρβακρόλης, που αποτελεί νέο φυσικό προϊόν. Η ταυτοποίηση των ενώσεων έγινε με τη χρήση φασματοσκοπικών μεθόδων, κυρίως 1D και 2D NMR (COSY, ROESY, NOESY, HSQC and HMBC) και φασματομετρία μάζας (HR-ESIMS)
description: Scope of this thesis was the phytochemical analysis of the non-volatile content of the Greek endemic species Origanum dictamnus L. Dittany, is a widely cultivated medicinal plant in Greece, while the Community Monograph (EMA Monograph) has opened the way for further exploitation of this important herb. In the present work two extracts were studied: the cyclohexanic, containing non-polar constituents, and the aqueous one, containing very polar ones. By use of classical chromatographic techniques such as Vaccum Liquid Chromatography (VLC), column chromatography (Silica, Sephadex L-20, Amberlite) and High Performance Liquid Chromatography thirteen compounds were isolated in pure form. These belong to different phytochemical groups such as terpenes, phenolic acids, flavonoids and alicyclic derivatives. One compound, dimer of carvacrol, was a new naturally occurring product. Structure elucidation was carried out by 1D and 2D NMR (COSY, ROESY, NOESY, HSQC and HMBC), as well as mass spectrometric analyzes (HR-ESIMS)
Evidence for Higgs boson decays to a low-mass dilepton system and a photon in pp collisions at $\sqrt{s} =$ 13 TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for the Higgs boson decaying into a photon and a pair of electrons or muons with an invariant mass $m_{\ell\ell} < 30$ GeV is presented. The analysis is performed using 139 fb$^{-1}$ of proton-proton collision data, produced by the LHC at a centre-of-mass energy of 13 TeV and collected by the ATLAS experiment. Evidence for the $H \rightarrow \ell \ell γ$ process is found with a significance of 3.2$σ$ over the background-only hypothesis, compared to an expected significance of 2.1$σ$. The best-fit value of the signal strength parameter, defined as the ratio of the observed signal yield to the one expected in the Standard Model, is $μ= 1.5 \pm 0.5$. The Higgs boson production cross-section times the $H \rightarrow\ell\ellγ$ branching ratio for $m_{\ell\ell}
description: 39 pages in total, author list starting page 23, 5 figures, 1 table, submitted to PLB, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2018-43/
rCASC implementation in Laniakea: porting containerization-based-reproducibility to a cloud Galaxy on-demand platform
Creators: name: Alessandrì, Luca
name: Mandreoli, Pietro
name: Tangaro, Marco Antonio
name: Beccuti, Marco
name: Calogero, Raffaele
name: Zambelli, Federico
Publisher: name: F1000 Research Limited
Year: 2019

description: Integrating rCASC in Laniakea: rCASC, Cluster Analysis of Single Cells [Alessandri et al. BioRxiv], is part of the reproducible-bioinformatics.org project and provides single cell analysis functionalities within the reproducible rules described by Sandve et al. [PLoS Comp Biol. 2013]. Laniakea [Tangaro et al. BioRxiv Bioinformatics] provides the possibility to automate the creation of Galaxy-based virtualized environments through an easy setup procedure, providing an on-demand workspace ready to be used by life scientists and bioinformaticians. The final goal is to offer rCASC as a Galaxy flavor in the Laniakea Galaxy on-demand environment.
Nonlinear optical Galton board
Creators: name: Navarrete-Benlloch, C.
name: Perez, A.
name: Roldan, Eugenio
Publisher: name: arXiv
Year: 2006
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We generalize the concept of optical Galton board (OGB), first proposed by Bouwmeester et al. {[}Phys. Rev. A \textbf{61}, 013410 (2000)], by introducing the possibility of nonlinear self--phase modulation on the wavefunction during the walker evolution. If the original Galton board illustrates classical diffusion, the OGB, which can be understood as a grid of Landau--Zener crossings, illustrates the influence of interference on diffusion, and is closely connected with the quantum walk. Our nonlinear generalization of the OGB shows new phenomena, the most striking of which is the formation of non-dispersive pulses in the field distribution (soliton--like structures). These exhibit a variety of dynamical behaviors, including ballistic motion, dynamical localization, non--elastic collisions and chaotic behavior, in the sense that the dynamics is very sensitive to the nonlinearity strength.
description: 8 pages, 8 figures
Μελέτη του κλάδου ακίνητης περιουσίας και της συμπεριφοράς των τιμών των ακινήτων
Creators: name: Αγγελίνου, Μαρία Ευστράτιου
Publisher: name: Aristotle University of Thessaloniki
Year: 2019
Subjects: Κλάδος ακινήτων
Τιμές
Αποτελεσματική αγορά
Real Estate
Prices
Effective Market

description: Η εν λόγω διατριβή έχει ως θέμα της την ανάλυση του κλάδου των Ανώνυμων Εταιρειών Επενδύσεων σε Ακίνητη Περιουσία (Real Estate Companies – REICs), καθώς και των τιμών των ακινήτων. Πιο συγκεκριμένα, η ανάλυση σχετίζεται με την εξέταση των τιμών της αγοράς ακινήτων, καθώς και με την δυνατότητα πρόβλεψης της πορείας των τιμών του εν λόγω κλάδου.
description: This dissertation deals with the analysis of the Real Estate Companies (REICs) sector as well as real estate prices. More specifically, the analysis relates to the examination of real estate prices and to the possibility of forecasting the course of prices in this sector.
2D Tellurium and Indium Oxide as Novel Channel Materials for Energy-Efficient Transistors
Creators: name: Long, Linjia
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 401804
subject: Nanoelectronics

description: As conventional silicon-based transistors approach their physical and performance limits, the search for alternative channel materials and device architecture has grown increasingly urgent. Two-dimensional (2D) materials offer a compelling path forward due to their atomic thinness, electrostatic gate control, and tunable electronic properties. Among them, tellurium (Te) stands out as a narrow-bandgap semiconductor with high carrier mobility for both electrons and holes, at least at cryogenic temperatures. In this work, we demonstrate ultralow-voltage Te field-effect transistors and complementary metal-oxide-semiconductor (CMOS) inverters. Leveraging self-formed metal contacts and engineered gate dielectrics, these Te-based devices exhibit sub-thermionic subthreshold swings, noise-free switching, and stable operation down to 0.08 V supply voltages. The resulting CMOS circuits display clear voltage transfer characteristics and gain, showcasing the viability of Te as a platform for energy-efficient logic.Beyond front-end innovation, realizing monolithic three-dimensional integration demands back-end-of-line (BEOL) compatible semiconductors. Amorphous In₂O₃, deposited via atomic layer deposition, offers promise due to its low processing temperature, excellent uniformity, and extremely low off-state current, making it ideal for low-power logic such as gain cells or potential complementary FET (CFET) architectures. In this study, over 10,000 In₂O₃-based FETs and ferroelectric FETs are fabricated on 200 mm wafers and thoroughly characterized. The FETs exhibit high yield, an average mobility of 91.6 cm²/V·s, and a tight threshold voltage distribution (σ = 0.11 V). Optimization of channel thickness and oxygen content enables a favorable trade-off among mobility, subthreshold slope, and threshold voltage. Ferroelectric In₂O₃-based FETs with HfZrOₓ gate dielectrics demonstrate a uniform memory window averaging 1.38 V with 99.0% yield and strong scalability as confirmed by channel length dependence.Together, the demonstration of ultralow-voltage CMOS circuits based on 2D Te and the statistical validation of energy-efficient In₂O₃ devices underscores the potential of these emerging semiconductors for next-generation low-power, high-density logic and memory systems. This work highlights the synergy between narrow-bandgap 2D semiconductors and scalable oxide electronics, establishing a foundation for continued innovation in advanced CMOS and BEOL-integrated architectures.
A Perfect Metamaterial Absorber
Creators: name: Landy, N. I.
name: Sajuyigbe, S.
name: Mock, J. J.
name: Smith, D. R.
name: Padilla, W. J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present the design for an absorbing metamaterial element with near unity absorbance. Our structure consists of two metamaterial resonators that couple separately to electric and magnetic fields so as to absorb all incident radiation within a single unit cell layer. We fabricate, characterize, and analyze a metamaterial absorber with a slightly lower predicted absorbance of 96%. This achieves a simulated full width at half maximum (FWHM) absorbance of 4% thus making this material ideal for imaging purposes. Unlike conventional absorbers, our metamaterial consists solely of metallic elements. The underlying substrate can therefore be chosen independently of the substrate's absorptive qualities and optimized for other parameters of interest. We detail the design and simulation process that led to our metamaterial, and our experiments demonstrate a peak absorbance greater than 88% at 11.5 GHz.
Optical properties of an extended gravitational lens
Creators: name: Turyshev, Slava G.
name: Toth, Viktor T.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We continue to study the optical properties of the solar gravitational lens (SGL). The aim is prospective applications of the SGL for imaging purposes. We investigate the solution of Maxwell's equations for the electromagnetic (EM) field, obtained on the background of a static gravitational field of the Sun. We now treat the Sun as an extended body with a gravitational field that can be described using an infinite series of gravitational multipole moments. Studying the propagation of monochromatic EM waves in this extended solar gravitational field, we develop a wave-optical treatment of the SGL that allows us to study the caustics formed in an image plane in the SGL's strong interference region. We investigate the EM field in several important regions, namely i) the area in the inner part of the caustic and close to the optical axis, ii) the region outside the caustic, and iii) the region in the immediate vicinity of the caustic, especially around its cusps and folds. We show that in the first two regions the physical behavior of the EM field may be understood using the method of stationary phase. However, in the immediate vicinity of the caustic the method of stationary phase is inadequate and a wave-optical treatment is necessary. Relying on the angular eikonal method, we develop a new approach to describe the EM field accurately in all regions, including the immediate vicinity of the caustics and especially near the cusps and folds. The method allows us to investigate the EM field in this important region, which is characterized by rapidly oscillating behavior. Our results are new and can be used to describe gravitational lensing by realistic astrophysical objects, such as stars, spiral and elliptical galaxies.
description: 25 pages, 10 figures
Characterizing the Online Learning Landscape: What and How People Learn Online
Creators: name: Kross, Sean
name: Hargittai, Eszter
name: Redmiles, Elissa M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Hundreds of millions of people learn something new online every day. Simultaneously, the study of online education has blossomed within the human computer interaction community, with new systems, experiments, and observations creating and exploring previously undiscovered online learning environments. In this study we endeavor to characterize this entire landscape of online learning experiences using a national survey of 2260 US adults who are balanced to match the demographics of the U.S. We examine the online learning resources that they consult, and we analyze the subjects that they pursue using those resources. Furthermore, we compare both formal and informal online learning experiences on a larger scale than has ever been done before, to our knowledge, to better understand which subjects people are seeking for intensive study. We find that there is a core set of online learning experiences that are central to other experiences and these are shared among the majority of people who learn online. We conclude by showing how looking outside of these core online learning experiences can reveal opportunities for innovation in online education.
description: 19 pages, To Appear in the Proceedings of the ACM (PACM) Human-Computer Interaction, CSCW 2021
MOESM1 of The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma
Creators: name: Zhu, Haibo
name: Miao, Yazhou
name: Shen, Yutao
name: Guo, Jing
name: Xie, Weiyan
name: Zhao, Sida
name: Dong, Wei
name: Zhang, Yazhuo
name: Li, Chuzhong
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Clinical information of ceRNA microarray.
Analytical calculation of neighborhood order probabilities for high dimensional Poissonic processes and mean field models
Creators: name: Tercariol, Cesar Augusto Sangaletti
name: Kiipper, Felipe de Mouta
name: Martinez, Alexandre Souto
Publisher: name: arXiv
Year: 2006
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Consider that the coordinates of $N$ points are randomly generated along the edges of a $d$-dimensional hypercube (random point problem). The probability that an arbitrary point is the $m$th nearest neighbor to its own $n$th nearest neighbor (Cox probabilities) plays an important role in spatial statistics. Also, it has been useful in the description of physical processes in disordered media. Here we propose a simpler derivation of Cox probabilities, where we stress the role played by the system dimensionality $d$. In the limit $d \to \infty$, the distances between pair of points become indenpendent (random link model) and closed analytical forms for the neighborhood probabilities are obtained both for the thermodynamic limit and finite-size system. Breaking the distance symmetry constraint drives us to the random map model, for which the Cox probabilities are obtained for two cases: whether a point is its own nearest neighbor or not.
description: 12 pages, 3 figures and 1 table
Additional file 1 of Utilising primary care electronic health records to deliver the ALABAMA randomised controlled trial of penicillin allergy assessment
Creators: name: Ahmed, Shadia
name: Fielding, Joanne
name: Porter, Catherine E.
name: Armitage, Kelsey F.
name: Wanat, Marta
name: Bates, Chris
name: Engonidou, Lazarina
name: West, Robert M.
name: Yu, Ly-Mee
name: Galal, Ushma
name: Howard, Philip
name: Butler, Christopher C.
name: Savic, Sinisa
name: Boards, Jenny
name: Tonkin-Crine, Sarah
name: Parry, John
name: Pavitt, Sue A.
name: Sandoe, Jonathan T.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Pharmacology
Biotechnology
Information Systems not elsewhere classified

description: Supplementary Material 1. Sect. 1: ALABAMA trial inclusion and exclusion criteria. Section 2: Supplementary figures. Figure S1. Process map and work instructions (WI) list for the Allergy antibiotic and microbial resistance (ALABAMA) trial (ClinicalTrials.gov: NCT04108637). Figure S2. The SystmOne ALABAMA electronic referral form used by general practitioners to refer patients into the ALABAMA unit and to confirm permission for sharing of the patient’s data. Figure S3. SystmOne template used in the ALABAMA trial to assign patients to a ‘caseload’ after randomisation. Figure S4. SystmOne template used in the ALABAMA trial to facilitate correct results and Read Code entry into a patients’ medical records. Section 3: Results. Table S1. ‘Y’ codes used to record penicillin allergy testing results. Section 4: Acknowledgements
Seeing the Invisible Axion in the Sparticle Spectrum
Creators: name: Conlon, Joseph P.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I describe how under favourable circumstances the invisible axion may manifest its existence at the LHC through the sparticle spectrum; in particular through a gluino \sim \ln (M_P/m_{3/2}) times heavier than other gauginos.
description: 4 pages, REVTeX
New directions for contact integrators
Creators: name: Bravetti, Alessandro
name: Seri, Marcello
name: Zadra, Federico
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 34A26, 34C15, 65P10

description: Contact integrators are a family of geometric numerical schemes which guarantee the conservation of the contact structure. In this work we review the construction of both the variational and Hamiltonian versions of these methods. We illustrate some of the advantages of geometric integration in the dissipative setting by focusing on models inspired by recent studies in celestial mechanics and cosmology.
description: To appear as Chapter 24 in GSI 2021, Springer LNCS 12829
Instability analysis for spiral arms of local galaxies: M51, NGC3627 and NGC628
Creators: name: Inoue, Shigeki
name: Takagi, Toshinobu
name: Miyazaki, Atsushi
name: Cooper, Erin Mentuch
name: Egusa, Fumi
name: Yajima, Hidenobu
Publisher: name: arXiv
Year: 2021
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate dynamical states of grand-design spiral arms in three local galaxies: M51, NGC3627 and NGC628. Based on linear perturbation analysis considering multiple components in the galaxies, we compute instability parameters of the spiral arms using their observational data and argue whether the arms will fragment by their self-gravity. Our analysis utilises observations of carbon monoxide (CO), 21-centimetre line emission and multi-band photometric images for molecular gas, atomic gas and stellar components in the arms, respectively. We find that the grand-design arms of these galaxies indicate marginally stable states, and hence they are not on the way to fragment. We consider this to be consistent with the commonness of spiral galaxies and the relative rarity of fragmented discs at low redshifts. In the analysis, molecular gas is the dominant component to determine the (in)stability of the arms, whereas atomic gas and stars are far less important. Therefore, the results of our analysis are sensitive to an assumed CO-to-H$_{\rm 2}$ conversion factor. If we assume a typical scatter of the measurements and admit nearly twice as large a conversion factor as our fiducial value, our analysis results in predicting the instability for the spiral arms. More sophisticated determination of the conversion factor is required for more accurate analysis for the (in)stability of spiral arms.
description: 14 pages, 10 figures. Accepted to MNRAS
Origin of charge density wave in the coupled spin ladders in Sr$_{14-x}$Ca$_x$Cu$_{24}$O$_{41}$
Creators: name: Wohlfeld, Krzysztof
name: Oles, Andrzej M.
name: Sawatzky, George A.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We formulate a d-p multiband charge transfer model for Cu$_2$O$_5$ coupled spin ladders, relevant for Cu$_2$O$_3$ plane of Sr$_{14-x}$Ca$_x$Cu$_{24}$O$_{41}$, and solve it using Hartree-Fock approximation. The results explain that (i) the charge density wave (CDW) with its periodicity dependent on doping is stabilized by purely electronic many-body interactions in a single spin ladder and (ii) the inclusion of the interladder interactions favors (disfavors) the stability of the CDW with odd (even) periodicity, respectively. This stays in agreement with recent experimental results and suggests the structure of the minimal microscopic model which should be considered in future more sophisticated studies.
description: 5 pages, 4 figures; figures made more transparent, typos corrected, one reference added, journal-ref added
Quantum Hall effect at cleaved InSb surfaces and low-temperature annealing effect
Creators: name: Masutomi, Ryuichi
name: Hio, Masayuki
name: Mochizuki, Toshimitsu
name: Okamoto, Tohru
Publisher: name: arXiv
Year: 2007
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have performed low-temperature in-plane magnetotransport measurements on two-dimensional electron systems induced by deposition of Ag at {\it in situ} cleaved surfaces of {\it p}-type InSb. The quantum Hall effect was observed even at low magnetic fields around 2 T. The surface electron density and the electron mobility exhibit strong dependence on the Ag-coverage and the annealing temperature in the range of 15-40 K. The annealing effect suggests that the surface morphology strongly affects the properties of the two-dimensional electron systems.
description: 3 pages, 2 figures
Additional file 1 of Capturing sources of health system legitimacy in fragmented conflict zones under different governance models: a case study of northwest Syria
Creators: name: Alkhalil, Munzer
name: Turkmani, Rim
name: Gharibah, Mazen
name: Patel, Preeti
name: Mehchy, Zaki
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Information Systems not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Supplementary Material 1.
MOESM2 of The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma
Creators: name: Zhu, Haibo
name: Miao, Yazhou
name: Shen, Yutao
name: Guo, Jing
name: Xie, Weiyan
name: Zhao, Sida
name: Dong, Wei
name: Zhang, Yazhuo
name: Li, Chuzhong
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Table S2. PCR primers of mRNAs used for qRT-PCR.
ETV4 and ETV5 orchestrate FGF-mediated lineage specification and epiblast maturation during early mouse development.
Creators: name: Simon, Claire S
name: Hur, Woonyung
name: Garg, Vidur
name: Kuo, Ying-Yi
name: Niakan, Kathy K
name: Hadjantonakis, Anna-Katerina
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Developmental Biology
subject: Developmental Biology
classificationCode: Gene Expression
subject: Gene Expression

description: Cell fate decisions in early mammalian embryos are tightly regulated processes crucial for proper development. While FGF signaling plays key roles in early embryo patterning, its downstream effectors remain poorly understood. Our study demonstrates that the transcription factors Etv4 and Etv5 are critical mediators of FGF signaling in cell lineage specification and maturation in mouse embryos. We show that loss of Etv5 compromises primitive endoderm formation at pre-implantation stages. Furthermore, Etv4/5 deficiency delays naïve pluripotency exit and epiblast maturation, leading to elevated NANOG and reduced OTX2 expression within the blastocyst epiblast. As a consequence of delayed pluripotency progression, Etv4/5 deficient embryos exhibit anterior visceral endoderm migration defects post-implantation, a process essential for coordinated embryonic patterning and gastrulation initiation. Our results demonstrate the successive roles of these FGF signaling effectors in early lineage specification and embryonic body plan establishment, providing new insights into the molecular control of mammalian development.
On an excitation mechanism for trapped inertial waves in discs around black holes
Creators: name: Ferreira, Barbara T.
name: Ogilvie, Gordon I.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: According to one model, high-frequency quasi-periodic oscillations (QPOs) can be identified with inertial waves, trapped in the inner regions of accretion discs around black holes due to relativistic effects. In order to be detected, their amplitudes need to reach large enough values via some excitation mechanism. We work out in detail a non-linear coupling mechanism suggested by Kato, in which a global warping or eccentricity of the disc has a fundamental role. These large-scale deformations combine with trapped modes to generate `intermediate' waves of negative energy that are damped as they approach either their corotation resonance or the inner edge of the disc, resulting in amplification of the trapped waves. We determine the growth rates of the inertial modes, as well as their dependence on the spin of the black hole and the properties of the disc. Our results indicate that this coupling mechanism can provide an efficient excitation of trapped inertial waves, provided the global deformations reach the inner part of the disc with non-negligible amplitude.
description: 15 pages, 7 figures, accepted for publication in MNRAS
Adapting time-delay interferometry for LISA data in frequency
Creators: name: Bayle, Jean-Baptiste
name: Hartwig, Olaf
name: Staab, Martin
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Time-delay interferometry (TDI) is a post-processing technique used to reduce laser noise in heterodyne interferometric measurements with unequal armlengths, a situation characteristic of space gravitational detectors such as Laser Interferometer Space Antenna (LISA). This technique consists in properly time-shifting and linearly combining the interferometric measurements in order to reduce the laser noise by several orders of magnitude and to detect gravitational waves. In this communication, we show that the Doppler shift due to the time evolution of the armlengths leads to an unacceptably large residual noise when using interferometric measurements expressed in units of frequency and standard expressions of the TDI variables. We also present a technique to mitigate this effect by including a scaling of the interferometric measurements in addition to the usual time-shifting operation when constructing the TDI variables. We demonstrate analytically and using numerical simulations that this technique allows one to recover standard laser noise suppression which is necessary to measure gravitational waves.
description: 7 pages, 4 figures
Additional file 2 of Capturing sources of health system legitimacy in fragmented conflict zones under different governance models: a case study of northwest Syria
Creators: name: Alkhalil, Munzer
name: Turkmani, Rim
name: Gharibah, Mazen
name: Patel, Preeti
name: Mehchy, Zaki
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Information Systems not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Supplementary Material 2.
Contact-line deposits from multiple evaporating droplets
Creators: name: Wray, Alexander W.
name: Wray, Patrick S.
name: Duffy, Brian R.
name: Wilson, Stephen K.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Building on the recent theoretical work of Wray, Duffy and Wilson [J. Fluid Mech. 884, A45 (2020)] concerning the competitive diffusion-limited evaporation of multiple thin sessile droplets in proximity to each other, we obtain theoretical predictions for the spatially non-uniform densities of the contact-line deposits (often referred to as "coffee stains" or "ring stains") left on the substrate after such droplets containing suspended solid particles have completely evaporated. Neighbouring droplets interact via their vapour fields, which results in a spatially non-uniform "shielding" effect. We give predictions for the deposits from a pair of identical droplets, which show that the deposit is reduced the most where the droplets are closest together, and demonstrate excellent quantitative agreement with experimental results of Pradhan and Panigrahi [Coll. Surf. A 482, 562-567 (2015)]. We also give corresponding predictions for a triplet of identical droplets arranged in an equilateral triangle, which show that the effect of shielding on the deposit is more subtle in this case.
Complex Behavior in Simple Models of Biological Coevolution
Creators: name: Rikvold, Per Arne
Publisher: name: arXiv
Year: 2006
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We explore the complex dynamical behavior of simple predator-prey models of biological coevolution that account for interspecific and intraspecific competition for resources, as well as adaptive foraging behavior. In long kinetic Monte Carlo simulations of these models we find quite robust 1/f-like noise in species diversity and population sizes, as well as power-law distributions for the lifetimes of individual species and the durations of quiet periods of relative evolutionary stasis. In one model, based on the Holling Type II functional response, adaptive foraging produces a metastable low-diversity phase and a stable high-diversity phase.
description: 8 pages, 5 figures
Property of the spectrum of large-scale magnetic fields from inflation
Creators: name: Bamba, Kazuharu
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The property of the spectrum of large-scale magnetic fields generated due to the breaking of the conformal invariance of the Maxwell theory through some mechanism in inflationary cosmology is studied. It is shown that the spectrum of the generated magnetic fields should not be perfectly scale-invariant but be slightly red so that the amplitude of large-scale magnetic fields can be stronger than $\sim 10^{-12}$G at the present time. This analysis is performed by assuming the absence of amplification due to the late-time action of some dynamo (or similar) mechanism.
description: 8 pages, no figure; references corrected
Black Holes in Pure Lovelock Gravities
Creators: name: Cai, Rong-Gen
name: Ohta, Nobuyoshi
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The Lovelock gravity is a fascinating extension of general relativity, whose action consists of the dimensionally extended Euler densities. Compared to other higher order derivative gravity theories, the Lovelock gravity is attractive since it has a lot of remarkable features such as that there are no more than second order derivatives with respect to metric in its equations of motion, and that the theory is free of ghost. Recently in the study of black string and black brane in the Lovelock gravity, a special class of Lovelock gravity is considered, which is named pure Lovelock gravity, where only one Euler density term exists. In this paper we study black hole solutions in the special class of Lovelock gravity and associated thermodynamic properties. Some interesting features are found, which are quite different from the corresponding ones in general relativity.
description: Latex, 14 pages with 2 eps figures, v2: Revtex, 17pages with 2 eps figures, minor changes and references added, to appear in PRD, v3: the version in PRD
Bone marrow transplantion : the experience of family members
Creators: name: Kerzner, Jaye C.
Publisher: name: University of British Columbia
Year: 2008

description: The purpose this qualitative study was to explore the experience of BMT from the perspective of individual family members and to describe common aspects of that experience, according to the phenomenological method. Data were collected through a series of open-ended interviews with eight family members of transplant recipients during the hospitalization phase of BMT. Initial interviews were loosely guided by research questions formulated from are view of the literature; subsequent interviews were based one mergent themes from the first interviews. The data, comprised of verbatim transcriptions of the audio taped interviews and field notes of the researcher, were analyzed using the steps outlined by Giorgi (1985) and resulted in the identification of recurrent themes. Findings revealed that family members attributed multiple meanings to bone marrow transplantation. They viewed it as a life-saving and a life-threatening event, radical treatment, pioneering venture, treatment with an unpredictable recovery period, and as an interruption in their lives. Family members were challenged by the uncertainty and disruption that BMT created in their lives. Their efforts to cope with the transplant centred around managing their emotions arising from the uncertainty and adjusting to the many disruptions in their lives. Since family members felt there was little they could do to influence the transplant outcome, they accepted uncertainty as an intrinsic part of the experience and focused on establishing and maintaining a balance between their fear and realistic hope. Family members adjusted to the disruptions in their daily life, relationships and life outlook by giving up certain daily responsibilities and taking on a support role in relation to the ill person, developing interpersonal connections with those dedicated to a positive transplant outcome and separating from those who undermined their coping, and by restricting their view of the future, redefining time and shifting priorities. The data revealed that generally, family members coped with the challenges of BMT using their own resources and abilities; however certain interpersonal and situational factors were identified which may signal a need for added support. The findings provide nurses with a better understanding of family members' responses to BMT and provide general direction for assessment of family members, predicting the difficulties family members may encounter, and helpful nursing interventions. Implications for future nursing research include further exploration of family members' experiences beyond the hospitalization phase, expansion of selected themes arising from the study, and inclusion of different sub-groups of family members whose experiences may differ from that of this study's participants.
Ιατρική, νομική και ηθική προσέγγιση των τεχνικών μιτοχονδριακής αντικατάστασης
Creators: name: Ντόμπρου, Ευαγγελία Σταμάτη
Publisher: name: Aristotle University of Thessaloniki
Year: 2019
Subjects: Μιτοχονδριακή αντικατάσταση
Δωρεά μιτοχονδρίων
Βιοηθική
Mitochondrial replacement
Donation of mitochondria
Bioethics

description: Σκοπός της διατριβής ήταν η μελέτη βιοηθικών προβληματισμών στο θέμα της μιτοχονδριακής αντικατάστασης. Παρουσιάσαμε τα βιολογικά, γενετικά και ιατρικά δεδομένα και τις διαθέσιμες προς εφαρμογή τεχνικές μιτοχονδριακής αντικατάστασης. Προσεγγίσαμε από νομικής πλευράς το πλαίσιο στο οποίο θα μπορούσαν να νομιμοποιηθούν οι τεχνικές μιτοχονδριακής αντικατάστασης. Στη συνέχεια παρουσιάσαμε αναλυτικά βιοηθικά ζητήματα που σχετίζονται με τη μιτοχονδριακή αντικατάσταση, όπως η ομοιότητά της με τη μεταμόσχευση οργάνων, η επιρροή των τεχνικών στη μοναδική ταυτότητα του ατόμου και το αν η δότρια έχει γονεϊκές ευθύνες απέναντι στο παιδί που γεννιέται. Άλλα θέματα με τα οποία ασχοληθήκαμε είναι η προτίμηση άλλων εναλλακτικών λύσεων, αβεβαιότητες ως προς τη χρήση των τεχνικών, το ζήτημα ανωνυμίας της δότριας και το αν είναι ηθικά αποδεκτή η χρήση των τεχνικών από λεσβιακά ζευγάρια.
description: The aim of the present thesis was the study of bioethical issues on mitochondrial replacement. We presented the biological, genetic and medical data and the available to be applied mitochondrial replacement techniques. We approached from a legal point of view the context in which the mitochondrial replacement techniques could be legitimized. Furthermore we presented analytically bioethical issues related to mitochondrial replacement, such as its similarity to organ transplantation, the impact of the techniques on the unique identity of the individual and whether the donor has parental responsibilities towards the child being born. Other issues we have dealt with are the preference of other alternatives, uncertainties about the use of the techniques, the donor anonymity issue and whether it is morally acceptable the techniques to be used by lesbian couples.
Additional file 1 of Roles of different organizations in implementing patient-reported measures in routine maternity care in Finland
Creators: name: Väyrynen, Kirsi Marja-Leena
name: Chen, An
name: Heinonen, Seppo
name: Tekay, Aydin
name: Torkki, Paulus
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Bayesian inference for continuous-time hidden Markov models with an unknown number of states
Creators: name: Luo, Yu
name: Stephens, David A.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Methodology (stat.ME)
subject: Computation (stat.CO)
subject: FOS: Computer and information sciences
subject: 62F15, 62M05, 60J27

description: We consider the modeling of data generated by a latent continuous-time Markov jump process with a state space of finite but unknown dimensions. Typically in such models, the number of states has to be pre-specified, and Bayesian inference for a fixed number of states has not been studied until recently. In addition, although approaches to address the problem for discrete-time models have been developed, no method has been successfully implemented for the continuous-time case. We focus on reversible jump Markov chain Monte Carlo which allows the trans-dimensional move among different numbers of states in order to perform Bayesian inference for the unknown number of states. Specifically, we propose an efficient split-combine move which can facilitate the exploration of the parameter space, and demonstrate that it can be implemented effectively at scale. Subsequently, we extend this algorithm to the context of model-based clustering, allowing numbers of states and clusters both determined during the analysis. The model formulation, inference methodology, and associated algorithm are illustrated by simulation studies. Finally, We apply this method to real data from a Canadian healthcare system in Quebec.
Peak, valley and intermediate regimes in the lateral van der Waals force
Creators: name: Nogueira, Edson C. M.
name: Queiroz, Lucas
name: Alves, Danilo T.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the van der Waals (vdW) interaction between a polarizable particle and a grounded conducting corrugated surface. For sinusoidal corrugations, one knows that, under the action of the lateral vdW force, an isotropic particle is always attracted to the nearest corrugation peak, with such behavior called in the present paper as peak regime. Here, considering an anisotropic polarizable particle, and making analytical calculations valid beyond the proximity force approximation (PFA), we show that the attraction is not only toward the peaks, but, for certain particle orientations and distances from the surface, the lateral force attracts the particle to the nearest corrugation valley (valley regime), or even to an intermediate point between a peak and a valley (intermediate regime). We also show that in the configurations of transition between the peak and valley regimes the lateral vdW force vanishes, even in the presence of a corrugated surface. In addition, we find that these new regimes occur in general, for periodic and nonperiodic corrugated surfaces. Moreover, we demonstrate that similar regimes arise in the classical interaction between a neutral polarized particle and a rough surface. The description of these valley and intermediate regimes, which are out of reach of the predictions based on the PFA, may be relevant for a better understanding of the interaction between anisotropic particles and corrugated surfaces in classical and quantum physics, with experimental verifications feasible in both domains.
description: 7 pages, 15 figures
MOESM3 of The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma
Creators: name: Zhu, Haibo
name: Miao, Yazhou
name: Shen, Yutao
name: Guo, Jing
name: Xie, Weiyan
name: Zhao, Sida
name: Dong, Wei
name: Zhang, Yazhuo
name: Li, Chuzhong
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 3: Table S3. Clinical information of 57 PAMs.
Additional file 1 of Bacterial seed endophytes promote barley growth and inhibits Fusarium graminearum in vitro
Creators: name: Ajayi, Oyeyemi
name: Grover, Suvir
name: Yimer, Belayneh
name: Vinje, Marcus
name: Mahalingam, Ramamurthy
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 1 Table S1 Barley genotypes and where they are grown (location). The barley varieties used and geographical locations from where the seeds were collected for this study, Table S2 In vitro antagonistic effect of bacterial endophytes on F. graminearum, the causative agent of Fusarium head blight in barley, Results of co-inoculation of promising bacterial endopyhtes and Fusarium graminearum. Antagonism was measured by size of inhibition zone and percentage of inhibition based on control.
Overcharging Extremal Black Holes
Creators: name: Ghosh, Rajes
name: Mishra, Akash K
name: Sarkar, Sudipta
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Weak Cosmic Censorship (WCC) conjecture can be used as a consistency criterion for any viable modification over general relativity (GR). We employ this idea to show that in contrast to the black holes in GR, it is indeed possible to overcharge modified extremal black hole solutions. Demanding the validity of WCC, we put some stringent constraints on various parameters of the theory. In particular, for charged Einstein-aether black hole, our method is strong enough to reproduce the identical bound on the parameter obtained previously from entirely different considerations.
description: 6 pages, no figures
Analysis of Rotation Curves in the Framework of the Gravitational Suppression Model
Creators: name: Martins, Christiane Frigerio
name: Salucci, Paolo
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present an analysis of suitable rotation curves (RCs) of eight galaxies, aimed at checking the consistency and universality of the gravitational suppression (GraS) hypothesis, a phenomenological model for a new interaction between dark matter and baryons. Motivated by the puzzle of the core versus cusp distribution of dark matter in the center of halos, this hypothesis claims to reconcile the predictions from N-body Λcold dark matter simulations with kinematic observations. The GraS model improves the kinematic fitting residuals, but the mass parameters are unphysical and put the theory in difficulty.
description: 4 pages, 3 figures, 1 table
Covariant phase space for gravity with boundaries: metric vs tetrad formulations
Creators: name: G., J. Fernando Barbero
name: Margalef-Bentabol, Juan
name: Varo, Valle
name: Villaseñor, Eduardo J. S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We use covariant phase space methods to study the metric and tetrad formulations of General Relativity in a manifold with boundary and compare the results obtained in both approaches. Proving their equivalence has been a long-lasting problem that we solve here by using the cohomological approach provided by the relative bicomplex framework. This setting provides a clean and ambiguity-free way to describe the solution spaces and associated symplectic structures. We also compute several relevant charges in both schemes and show that they are equivalent, as expected.