cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Transgenic overexpression of miR-133a in skeletal muscle
Creators: name: Chen, Jian Fu
name: Wang, Da Zhi
name: Deng, Zhongliang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: BackgroundMicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ~22 nucleotides in length. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) of their regulatory target mRNAs. Recent work has begun to reveal roles for miRNAs in a wide range of biological processes, including cell proliferation, differentiation and apoptosis. Many miRNAs are expressed in cardiac and skeletal muscle, and dysregulated miRNA expression has been correlated with muscle-related disorders. We have previously reported that the expression of muscle-specific miR-1 and miR-133 is induced during skeletal muscle differentiation and miR-1 and miR-133 play central regulatory roles in myoblast proliferation and differentiation in vitro.MethodsIn this study, we measured the expression of miRNAs in the skeletal muscle of mdx mice, an animal model for human muscular dystrophy. We also generated transgenic mice to overexpress miR-133a in skeletal muscle.ResultsWe examined the expression of miRNAs in the skeletal muscle of mdx mice. We found that the expression of muscle miRNAs, including miR-1a, miR-133a and miR-206, was up-regulated in the skeletal muscle of mdx mice. In order to further investigate the function of miR-133a in skeletal muscle in vivo, we have created several independent transgenic founder lines. Surprisingly, skeletal muscle development and function appear to be unaffected in miR-133a transgenic mice.ConclusionsOur results indicate that miR-133a is dispensable for the normal development and function of skeletal muscle.
Procesvalg, rekvisition og forberedelse– regelgrundlaget for proces før skelforretningen
Creators: name: Skovsgaard, Tanja Lindgaard
Publisher: name: Tidsskrift for Kortlægning og Arealforvaltning
Year: 2014

description: I artiklen redegøres for reglerne, der ligger til grund for processen før skelforret-ningen. Begrænsningen i parternes adgang til domstolene problematiseres. Det konstateres, at retsvirkning af henholdsvis rekvisition og indkaldelse ikke er fuldt afklarede. Der argumenteres endvidere for, at kravene til oplysning af sagens parter er utilstrækkelige.
description: Tidsskrift for Kortlægning og Arealforvaltning, Vol 122 No 47 (2014)
CONSTRAINED BETA-AMINO ACIDS AS MOLECULAR TOOLS FOR THE PREPARATION OF FOLDAMERS
Creators: name: BUCCI, RAFFAELLA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: In these three years, as PhD student, I was involved in different projects regarding the synthesis of new enantiopure beta-amino acids, their use for the preparation of small alpha/beta-peptide sequences and the study of their secondary structure. All hybrid alpha/beta-peptides were studied using NMR Spectroscopy (1H, 13C, HMBC, HMQC, NOESY; ROESY). Molecular modelling was also performed in collaboration with Prof. Contini, from DISFARM, Universit� degli Studi di Milano. In the first part of my thesis I reported on the synthesis of: - tetrahydroisoquinoline 4-carboxylic acid and its use in the preparation of alpha/beta-peptides. This new beta-amino acid, coupled with beta-Ala, can stabilize a flexible reverse turn conformation, depending on its stereochemistry; - beta-Morpholino-amino acid. This new beta-amino acid, prepared in enantiopure form, stabilizes a reverse gamma-turn conformation when inserted in alpha/beta-peptides; - beta2,3-diaryl-amino acids and preparation of alpha/beta-peptides. The secondary structure of each peptide was studied. Moreover, self-assembly of a ???-tripeptide composed by the beta2,3-diaryl amino acid coupled with L-Ala-L-Arg was investigated. In the second part of this thesis I focused on two other subjects beyond the beta-amino acids, that are: - the synthesis of isoxazoline containing scaffold. Also in this case, model peptides were prepared and their secondary structure were studied; it was found that our scaffold induce a turn able to stabilize a beta-hairpin. - the synthesis and study on Double Functionalized Collagen Model Peptides. This part of my thesis was performed during my internship at ETH (Eidgen�ssische Technische Hochschule, Z�rich, Switzerland) in Wennemers Group.
ARock: an Algorithmic Framework for Asynchronous Parallel Coordinate Updates
Creators: name: Peng, Zhimin
name: Xu, Yangyang
name: Yan, Ming
name: Yin, Wotao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Finding a fixed point to a nonexpansive operator, i.e., $x^*=Tx^*$, abstracts many problems in numerical linear algebra, optimization, and other areas of scientific computing. To solve fixed-point problems, we propose ARock, an algorithmic framework in which multiple agents (machines, processors, or cores) update $x$ in an asynchronous parallel fashion. Asynchrony is crucial to parallel computing since it reduces synchronization wait, relaxes communication bottleneck, and thus speeds up computing significantly. At each step of ARock, an agent updates a randomly selected coordinate $x_i$ based on possibly out-of-date information on $x$. The agents share $x$ through either global memory or communication. If writing $x_i$ is atomic, the agents can read and write $x$ without memory locks. Theoretically, we show that if the nonexpansive operator $T$ has a fixed point, then with probability one, ARock generates a sequence that converges to a fixed points of $T$. Our conditions on $T$ and step sizes are weaker than comparable work. Linear convergence is also obtained. We propose special cases of ARock for linear systems, convex optimization, machine learning, as well as distributed and decentralized consensus problems. Numerical experiments of solving sparse logistic regression problems are presented.
description: updated the linear convergence proofs
The Anisotropic Line Correlation Function as a Probe of Anisotropies in Galaxy Surveys
Creators: name: Eggemeier, Alexander
name: Battefeld, Thorsten
name: Smith, Robert E.
name: Niemeyer, Jens
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose an anisotropic generalisation of the line correlation function (ALCF) to separate and quantify phase information in the large-scale structure of galaxies. The line correlation function probes the strictly non-linear regime of structure formation and since phase information drops out of the power spectrum, the line correlation function provides a complementary tool to commonly used techniques based on two-point statistics. Furthermore, it is independent of linear bias as well as the Gaussian variance on the modulus of the density field and thus may also prove to be advantageous compared to the bispectrum or similar higher-order statistics for certain cases. For future applications it is vital, though, to be able to account for observational effects that cause anisotropies in the distribution of galaxies. Based on a number of numerical studies, we find that our ALCF is well suited to accomplish this task and we demonstrate how the Alcock-Paczynski effect and kinematical redshift-space distortions can in principle be measured via the ALCF.
description: 14 pages
Risk factors for revision of primary total hip arthroplasty: a systematic review
Creators: name: Katz, Jeffrey N.
name: Prokopetz, Julian Jz
name: Wright, John
name: Baron, John A.
name: Bliss, Robin L.
name: Losina, Elena
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundNumerous papers have been published examining risk factors for revision of primary total hip arthroplasty (THA), but there have been no comprehensive systematic literature reviews that summarize the most recent findings across a broad range of potential predictors.MethodsWe performed a PubMed search for papers published between January, 2000 and November, 2010 that provided data on risk factors for revision of primary THA. We collected data on revision for any reason, as well as on revision for aseptic loosening, infection, or dislocation. For each risk factor that was examined in at least three papers, we summarize the number and direction of statistically significant associations reported.ResultsEighty-six papers were included in our review. Factors found to be associated with revision included younger age, greater comorbidity, a diagnosis of avascular necrosis (AVN) as compared to osteoarthritis (OA), low surgeon volume, and larger femoral head size. Male sex was associated with revision due to aseptic loosening and infection. Longer operating time was associated with revision due to infection. Smaller femoral head size was associated with revision due to dislocation.ConclusionsThis systematic review of literature published between 2000 and 2010 identified a range of demographic, clinical, surgical, implant, and provider variables associated with the risk of revision following primary THA. These findings can inform discussions between surgeons and patients relating to the risks and benefits of undergoing total hip arthroplasty.
Absence of chloride intracellular channel 4 (CLIC4) predisposes to acute kidney injury but has minimal impact on recovery
Creators: name: Bruno, Jonathan
name: Edwards, John C.
name: Cheng, Yao Wen
name: Key, Phillip
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundCLIC4, a member of the CLIC family of proteins, was recently demonstrated to translocate to the nucleus in differentiating keratinocytes where it potentiates TGFβ-driven gene regulation. Since TGFβ signaling is known to play important roles in the fibrotic response to acute kidney injury, and since CLIC4 is abundantly expressed in kidney, we hypothesized that CLIC4 may play a role in the response to acute kidney injury.MethodsPreviously described Clic4 null mice were analyzed for the effect of absence of CLIC4 on growth, development and response to kidney injury. Kidney size, glomerular counts and density of peritubular capillaries of matched WT and Clic4 null mice were determined. Cohorts of WT and Clic4 null mice were subjected to the folic acid model of acute kidney injury. Extent of acute injury and long term functional recovery were assessed by plasma blood urea nitrogen (BUN); long term fibrosis/scarring was determined by histochemical assessment of kidney sections and by residual renal mass. Activation of the TGFβ signaling pathway was assessed by semi-quantitative western blots of phosphorylated SMADs 2 and 3.ResultsCLIC4 is abundantly expressed in the apical pole of renal proximal tubule cells, and in endothelial cells of glomerular and peritubular capillaries. CLIC4 null mice are small, have smaller kidneys with fewer glomeruli and less dense peritubular capillary networks, and have increased proteinuria. The Clic4 null mice show increased susceptibility to folic acid-induced acute kidney injury but no difference in recovery from acute injury, no nuclear redistribution of CLIC4 following injury, and no significant difference in activation of the TGFβ-signaling pathway as reflected in the level of phosphorylation of SMADs 2 and 3.ConclusionsAbsence of CLIC4 results in morphologic changes consistent with its known role in angiogenesis. These changes may be at least partially responsible for the increased susceptibility to acute kidney injury. However, the absence of CLIC4 has no significant impact on the extent of functional recovery or fibrosis following acute injury, indicating that CLIC4 does not play a major non-redundant role in the TGFβ signaling involved in response to acute kidney injury.
On the existence of Euler-Lagrange orbits satisfying the conormal boundary conditions
Creators: name: Asselle, Luca
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics

description: Let $(M,g)$ be a closed Riemannian manifold, $L: TM\rightarrow \mathbb R$ be a Tonelli Lagrangian. Given two closed submanifolds $Q_0$ and $Q_1$ of $M$ and a real number $k$, we study the existence of Euler-Lagrange orbits with energy $k$ connecting $Q_0$ to $Q_1$ and satisfying the conormal boundary conditions. We introduce the Mañé critical value which is relevant for this problem and discuss existence results for supercritical and subcritical energies. We also provide counterexamples showing that all the results are sharp.
description: In this revised version some sharper examples have been added in Section 6 and some gaps have been eliminated. To appear in Journal of Functional Analysis
Sagens oplysning – regelgrundlaget for proces i skelforretningssager
Creators: name: Skovsgaard, Tanja Lindgaard
Publisher: name: Tidsskrift for Kortlægning og Arealforvaltning
Year: 2014

description: I artiklen redegøres for reglerne, der ligger til grund for sagens oplysning ved skelforretninger. Det slås fast, at ansvaret for sagens oplysning alene ligger hos den landinspektør, der leder skelforretningen. Der argumenteres for, at kontradiktionsprincippet også må være gældende ved skelforretninger samtidig med, at det konstateres, at det fortsat er uafklaret, hvor vidtgående krav til kontradiktion parterne kan stille. Endelig problematiseres sammenhængen i parternes adgang til kontradiktion, beviser før skelforretningen og deltagelse i skelforretningen.
description: Tidsskrift for Kortlægning og Arealforvaltning, Vol 122 No 47 (2014)
Dependent Inductive and Coinductive Types are Fibrational Dialgebras
Creators: name: Basold, Henning
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: In this paper, I establish the categorical structure necessary to interpret dependent inductive and coinductive types. It is well-known that dependent type theories à la Martin-Löf can be interpreted using fibrations. Modern theorem provers, however, are based on more sophisticated type systems that allow the definition of powerful inductive dependent types (known as inductive families) and, somewhat limited, coinductive dependent types. I define a class of functors on fibrations and show how data type definitions correspond to initial and final dialgebras for these functors. This description is also a proposal of how coinductive types should be treated in type theories, as they appear here simply as dual of inductive types. Finally, I show how dependent data types correspond to algebras and coalgebras, and give the correspondence to dependent polynomial functors.
description: In Proceedings FICS 2015, arXiv:1509.02826
D7.1 Data Management Plan
Creators: name: Malzahn, Nils
name: Drachman, Raul
Publisher: name: Zenodo
Year: 2020
Subjects: citizen science

description: Our project is about data and information. Responding to the Call, we will expand our knowledge on Citizen Science (CS) and its impact. We will seek this increased knowledge by “observing” a large and diverse set of CS projects, gathering data from the web, questionnaires and interviews of involved players, etc., and from a more direct inspection of running activities. Vast amounts of data will thus be studied, relying for this on (1) web-based analytics, i.e. the use of computational analyses to study CS activities based on their manifestations on the web and social media, and (2) deepening and combining the obtained data and information through multi-perspective analysis and triangulation. Our data analytics and analysis will target both “own” aspects and developments of the CS projects (organizational/operational characteristics, scientific outcomes, good practices, individual/group learning, etc.), and societal aspects, related to the impact of those activities on society, such as gender, age, geographical and socioeconomic aspects; science role in society, changing attitudes to science, etc. All these reflect directly on questions pertaining to data and data management from all conceivable angles – collection, storage, safekeeping, preservation, accessibility, retrieval, ethical considerations, etc. –, which are addressed in this Plan. As not all the relevant questions have been solved (or even posed), this document has to be seen, at least for the next many months, as work in progress. We plan to update it on a current basis, issuing interim versions as important modifications will accumulate.
MPEC 2024-R202 : COMET P/2024 R2 (PANSTARRS)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET P/2024 R2 (PANSTARRS)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Prevalence, characteristics and correlates of a positive-dementia screen in patients on antiretroviral therapy in Bamenda, Cameroon: a cross-sectional study
Creators: name: Tayong, Gladys
name: Gaynes, Bradley N.
name: Njamnshi, Alfred K.
name: Ndumbe, Peter M.
name: O'donnell, Julie K.
name: Pence, Brian W.
name: Kats, Dmitry
name: Atashili, Julius
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundIn this study we assess the prevalence, characteristics as well as socio-demographic and clinical correlates of a positive screen for HIV-associated dementia in a group of patients on antiretroviral therapy (ART) in Bamenda, Cameroon.MethodsIn a cross-sectional study, a structured questionnaire was used to collect data on 400 patients attending the Bamenda Regional Hospital AIDS-treatment Centre. Patients were assessed for neurocognitive function using the International HIV Dementia Scale (IHDS) to assess finger-tapping (FT), alternating hand sequence (AHS) and a 4-word recall (4WR), each scored on a maximum of four.ResultsA total of 297 (74%) participants were females. The total IHDS score ranged from 6–12 with a mean of 9.02 and 85% of subjects screened positive for dementia (≤10 on IHDS). Participants performed worst in the AHS assessment with a mean of 2.25 (IQR: 2–3). In multivariable analyses, screening positive for dementia was significantly associated with having primary education or less (aOR: 8.33, 95%CI: 3.85, 16.67), and having HIV symptoms (aOR: 12.16, 95%CI: 3.08, 48.05).ConclusionsA very high proportion of patients on ART screened positive for dementia using the IHDS. This could potentially be an indication of a high prevalence of HIV-associated neurocognitive disorders in this population and or a poor performance of the IHDS in patients on ART. Future studies will need to assess the validity of the IHDS in this population of patients on ART and also evaluate long term outcomes in patients with positive dementia screens.
Sustainable Urban Development – Compact Cities or Consumer Practices?
Creators: name: Jensen, Jesper Ole
name: Christensen, Toke Haunstrup
name: Gram-Hanssen, Kirsten
Publisher: name: Tidsskrift for Kortlægning og Arealforvaltning
Year: 2014

description: Sustainability in urban planning has a long history and it has been a widespread solution to build high and compact in order to minimise the need for transportation, land use and heating. Recent research, however, points towards the need for a supplementary approach, which includes the consumer behaviour of the household. This approach necessarily has to work from below and include the citizens, as it is their daily practices that have to be challenged. This article reviews selected literature and studies on whether compact cities leads to more sustainable cities, and it use lifestyle interpretations of urbane forms to challenge the compact cities approach. As an alternative or supplementary approach the article introduce practice theory as a way to understand consumption and it gives examples on how this approach can be used to inspire local authorities to alternative and supplementary strategies of achieving sustainable urban development.
description: Tidsskrift for Kortlægning og Arealforvaltning, Vol 119 No 46 (2011)
Bike Infrastructures and Design Qualities: Enhancing Cycling
Creators: name: Andrade, Victor
name: Jensen, Ole B.
name: Harder, Henrik
name: Madsen, Jens C. O.
Publisher: name: Tidsskrift for Kortlægning og Arealforvaltning
Year: 2014

description: Decisions on transportation projects are typically – alongside the project costs – based on the potential for the project to contribute to broad public policy goals. Information on how specific design qualities enhance cycling will help decision makers to develop better and more cost-­‐ effective bike infrastructures. This article aims to present findings of the research project titled Bikeability – funded by the Danish Research Council. The overall purpose of the Bikeability project is to investigate and document relations between cycling motivation from different socio-­‐ demographic groups and distinct design characteristics related to the urban environment and the bike infrastructure. The part of the project described in this article concerns an in-­‐depth case study of three bike infrastructures with distinct typologies – Vestergade Vest/Mageløs in Odense; Hans Broges Gade in Aarhus and Bryggebroen in Copenhagen. The main element of the case studies is a questionnaire amongst users of the three infrastructures allowing the determination of socio-­‐ economic characteristics of the users and effects of the infrastructure in terms of the use of bike. Furthermore, the users were asked to assess the infrastructure project as well as to describe what specific design element primarily motivated them to travel by bike. The findings highlight the critical role of fast connectivity and fast bike lanes in motivating cyclists to ride their bikes more often. It also indicates that it is challenging to ensure the perception of safety in shared-­‐used spaces. These are findings that should be taken into consideration by architects, planners and engineers when designing bike infrastructures. Bridging research and policy, the findings of this research project can also support bike friendly design and planning, and cyclist advocacy.
description: Tidsskrift for Kortlægning og Arealforvaltning, Vol 119 No 46 (2011)
which psychological need frustration has the strongest association with adolescent depressive symptoms: the protective role of self-esteem
Creators: name: Liu, Xin
Publisher: name: figshare
Year: 2023
Subjects: Child and adolescent development
Health psychology

description: This is a raw data from a study on psychological needs frustration and adolescent depression. Variables included are need frustration, self-esteem, and depressive symptoms, as well as demographic variables age, gender, grade, and monthly household income.
Asymptotic of Number of Similarity Classes of Commuting Tuples
Creators: name: Sharma, Uday Bhaskar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A16

description: We have for positive integers $n$, $k$ and finite field $\mathbb{F}_q$, $c(n,k,q)$, as the number of simultaneous similarity classes of $k$-tuples of commuting $n\times n$ matrices over the $\mathbb{F}_q$. In this paper, it has been shown that $c(n,k,q)$ as a function of $k$ for fixed $n$ and $q$ is asymptotically $q^{m(n)k}$, where $m(n) = \left[\frac{n^2}{4}\right] + 1$, which is the dimension of the maximal commutative subalgebra of $M_n(\mathbb{F}_q)$ (the algebra of $n\times n$ matrices over $\mathbb{F}_q$).
description: 13 Pages, 1 Table
Web-based tool for dynamic functional outcome after acute ischemic stroke and comparison with existing models
Creators: name: Shen, Haipeng
name: Pan, Yuesong
name: Wang, Yongjun
name: Zhao, Xingquan
name: Li, Hao
name: Du, Wanliang
name: Wang, Penglian
name: Ji, Ruijun
name: Liu, Gaifen
name: Wang, Yilong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundAcute ischemic stroke (AIS) is one of the leading causes of death and adult disability worldwide. In the present study, we aimed to develop a web-based risk model for predicting dynamic functional status at discharge, 3-month, 6-month, and 1-year after acute ischemic stroke (Dynamic Functional Status after Acute Ischemic Stroke, DFS-AIS).MethodsThe DFS-AIS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Good functional outcome was defined as modified Rankin Scale (mRS) score ≤ 2 at discharge, 3-month, 6-month, and 1-year after AIS, respectively. Independent predictors of each outcome measure were obtained using multivariable logistic regression. The area under the receiver operating characteristic curve (AUROC) and plot of observed and predicted risk were used to assess model discrimination and calibration.ResultsA total of 12,026 patients were included and the median age was 67 (interquartile range: 57–75). The proportion of patients with good functional outcome at discharge, 3-month, 6-month, and 1-year after AIS was 67.9%, 66.5%, 66.9% and 66.9%, respectively. Age, gender, medical history of diabetes mellitus, stroke or transient ischemic attack, current smoking and atrial fibrillation, pre-stroke dependence, pre-stroke statins using, admission National Institutes of Health Stroke Scale score, admission blood glucose were identified as independent predictors of functional outcome at different time points after AIS. The DFS-AIS was developed from sets of predictors of mRS ≤ 2 at different time points following AIS. The DFS-AIS demonstrated good discrimination in the derivation and validation cohorts (AUROC range: 0.837-0.845). Plots of observed versus predicted likelihood showed excellent calibration in the derivation and validation cohorts (all r = 0.99, P < 0.001). When compared to 8 existing models, the DFS-AIS showed significantly better discrimination for good functional outcome and mortality at discharge, 3-month, 6-month, and 1-year after AIS (all P < 0.0001).ConclusionThe DFS-AIS is a valid risk model to predict functional outcome at discharge, 3-month, 6-month, and 1-year after AIS.Electronic supplementary materialThe online version of this article (doi:10.1186/s12883-014-0214-z) contains supplementary material, which is available to authorized users.
D3.2 Web Analytics Toolset and Workbench
Creators: name: Schulten, Cleo
name: Manske, Sven
name: Martínez, Fernando Martínez
name: Álvarez, David Roldán
name: Hoppe, H. Ulrich
Publisher: name: Zenodo
Year: 2021
Subjects: citizen science

description: The “Analytics Workbench” is a software platform developed within the CS Track project as a product of Task T3.2. The main deliverable is a software published on GitHub under an opensource software license. In addition to the software, this document provides an overview of the functional characteristics of the Analytics Workbench. In month 24, a workshop with potential users from the stakeholder groups has been conducted to evaluate the usability and utility of the tool. Preliminary results of the evaluation are included in this deliverable.
Finding the Event Structure of Neuronal Spike Trains
Creators: name: Tiesinga, Paul H.
name: Sejnowski, Terrence J.
name: Thomas, Peter J.
name: Vincent Toups, J.
name: Fellous, Jean Marc
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Neurons in sensory systems convey information about physical stimuli in their spike trains. In vitro, single neurons respond precisely and reliably to the repeated injection of the same fluctuating current, producing regions of elevated firing rate, termed events. Analysis of these spike trains reveals that multiple distinct spike patterns can be identified as trial-to-trial correlations between spike times (Fellous, Tiesinga, Thomas, & Sejnowski, 2004). Finding events in data with realistic spiking statistics is challenging because events belonging to different spike patterns may overlap. We propose a method for finding spiking events that uses contextual information to disambiguate which pattern a trial belongs to. The procedure can be applied to spike trains of the same neuron across multiple trials to detect and separate responses obtained during different brain states. The procedure can also be applied to spike trains from multiple simultaneously recorded neurons in order to identify volleys of near-synchronous activity or to distinguish between excitatory and inhibitory neurons. The procedure was tested using artificial data as well as recordings in vitro in response to fluctuating current waveforms.
Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons
Creators: name: Kachar, Bechara
name: Grati, M'hamed
name: Yang, Jun
name: Bhat, Manzoor A.
name: Green, James A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundMyelinated axons are organized into distinct subcellular and molecular regions. Without proper organization, electrical nerve conduction is delayed, resulting in detrimental physiological outcomes. One such region is the paranode where axo-glial septate junctions act as a molecular fence to separate the sodium (Na+) channel-enriched node from the potassium (K+) channel-enriched juxtaparanode. A significant lack of knowledge remains as to cytoskeletal proteins which stabilize paranodal domains and underlying cytoskeleton. Whirlin (Whrn) is a PDZ domain-containing cytoskeletal scaffold whose absence in humans results in Usher Syndromes or variable deafness-blindness syndromes. Mutant Whirlin (Whrn) mouse model studies have linked such behavioral deficits to improper localization of critical transmembrane protein complexes in the ear and eye. Until now, no reports exist about the function of Whrn in myelinated axons.ResultsRT-PCR and immunoblot analyses revealed expression of Whrn mRNA and Whrn full-length protein, respectively, in several stages of central and peripheral nervous system development. Comparing wild-type mice to Whrn knockout (Whrn−/−) mice, we observed no significant differences in the expression of standard axonal domain markers by immunoblot analysis but observed and quantified a novel paranodal compaction phenotype in 4 to 8week-old Whrn−/− nerves. The paranodal compaction phenotype and associated cytoskeletal disruption was observed in Whrn−/− mutant sciatic nerves and spinal cord fibers from early (2week-old) to late (1year-old) stages of development. Light and electron microscopic analyses of Whrn knockout mice reveal bead-like swellings in cerebellar Purkinje axons containing mitochondria and vesicles by both. These data suggest that Whrn plays a role in proper cytoskeletal organization in myelinated axons.ConclusionsDomain organization in myelinated axons remains a complex developmental process. Here we demonstrate that loss of Whrn disrupts proper axonal domain organization. Whrn likely contributes to the stabilization of paranodal myelin loops and axonal cytoskeleton through yet unconfirmed cytoskeletal proteins. Paranodal abnormalities are consistently observed throughout development (2 wk-1yr) and similar between central and peripheral nervous systems. In conclusion, our observations suggest that Whrn is not required for the organization of axonal domains, but once organized, Whrn acts as a cytoskeletal linker to ensure proper paranodal compaction and stabilization of the axonal cytoskeleton in myelinated axons.
Development and Initial Validation of Quality-of-Life Questionnaires for Intermittent Exotropia
Creators: name: Leske, David A.
name: Holmes, Jonathan M.
name: Yamada, Tomohiko
name: Hatt, Sarah R.
name: Bradley, Elizabeth A.
name: Cole, Stephen R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: We report the development and initial validation of patient–derived, health related quality of life (HRQOL) questionnaires for intermittent exotropia (IXT).
Futures of rural and peripheral areas
Creators: name: Nørgaard, Helle
Publisher: name: Tidsskrift for Kortlægning og Arealforvaltning
Year: 2014

description: Regional processes have transformed rural and peripheral areas throughout Europe through spatial, functional and social changes and in terms of stagnating economies as well as population decline. In response to this, the so-­‐called 'new rural paradigm' was developed where key elements are a focus on places rather than sectors and on investments rather than subsidies, stressing the need for building on local strengths and qualities. An overall goal within the EU is to pursue economic, social and territorial cohesion and although Danish policies aim for balanced regional growth and development various reforms seem to pull in a different direction. More specifically, a range of reforms has been consolidating functions and institutions and thereby centralizing growth and development. This article discusses challenges, futures and possibilities on rural and peripheral areas in Denmark and identifies a potential mismatch between different policies, reforms and strategies in relation to challenges of these areas.
description: Tidsskrift for Kortlægning og Arealforvaltning, Vol 119 No 46 (2011)
Quatro olhares sobre a cidade
Creators: name: Negreiros, Almada
name: Marques, Bernardo
name: Botelho, Carlos
name: Silva, Vieira Da
Publisher: name: Povos e Culturas
Year: 1998

description: Povos e Culturas, v. 6 (1998): Lisboa: contemporaneidade e futuro. Religião em África
Baseline Predictors of Visual Acuity and Retinal Thickness Outcomes in Patients with Retinal Vein Occlusion. SCORE Study Report 10
Creators: name: Vanveldhuisen, Paul C.
name: Scott, Ingrid U.
name: Blodi, Barbara A.
name: Ip, Michael S.
name: Hartnett, Mary Elizabeth
name: Cohen, Geoff
name: Oden, Neal L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To investigate baseline factors significantly associated with visual acuity and central retinal thickness outcomes in patients with macular edema secondary to retinal vein occlusion in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study.
Local density of Caputo-stationary functions in the space of smooth functions
Creators: name: Bucur, Claudia
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We consider the Caputo fractional derivative and say that a function is Caputo-stationary if its Caputo derivative is zero. We then prove that any $C^k\big([0,1]\big)$ function can be approximated in $[0,1]$ by a a function that is Caputo-stationary in $[0,1]$, with initial point $a<0$. Otherwise said, Caputo-stationary functions are dense in $C^k_{loc}(\mathbb{R})$.
description: 19 pages, 4 figures
Ten-year longitudinal changes in retinal microvascular lesions: The atherosclerosis risk in communities study
Creators: name: Wang, Jie Jin
name: Wong, Tien Y.
name: Sharrett, A. Richey
name: Campbell, Stephen
name: Cotch, Mary Frances
name: Klein, Ronald
name: Klein, Barbara E.K.
name: Liew, Gerald
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: There are limited data on the natural history and longitudinal changes of retinal microvascular lesions. We examined 10-year changes in retinal microvascular lesions, focusing on those related to hypertension and shown to predict development of cardiovascular disease.
MPEC 2024-R203 : 2024 RR8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RR8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Regler om proceselementer og procesrækkefølge ved skelforretninger
Creators: name: Skovsgaard, Tanja Lindgaard
Publisher: name: Tidsskrift for Kortlægning og Arealforvaltning
Year: 2017

description: I artiklen redegøres for, hvilke proceselementer der skal indgå i en skelforretning, og der søges udledt en procesrækkefølge. Endvidere foretages en sammenligning mellem gældende og tidligere regler. I den forbindelse problematiseres det, at regler vedrørende flere proceselementer blev fjernet ved udstykningsreformen, der trådte i kraft i 1991. Det blev stillet Folketinget i udsigt, at reglerne skulle flyttes til en ny skelforretningsbekendtgørelse. Men dette skete ikke
description: Tidsskrift for Kortlægning og Arealforvaltning, Vol 123 No 48 (2017)
The Relationship between Glaucoma Medication Adherence, Eye Drop Technique, and Visual Field Defect Severity
Creators: name: Stone, Jennifer L.
name: Muir, Kelly
name: Skinner, Asheley Cockrell
name: Robin, Alan L.
name: Blalock, Susan
name: Covert, David
name: Sleath, Betsy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The purpose of the study was to examine: (a) how patient adherence and eye drop technique were associated with visual field defect severity and (b) how general glaucoma adherence self-efficacy and eye drop technique self-efficacy were related to visual field defect severity.
Triangular lattice exciton model
Creators: name: Gunlycke, Daniel
name: Tseng, Frank
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a minimalistic equilateral triangular lattice model, from which we derive electron and exciton band structures for semiconducting transition-metal dichalcogenides. With explicit consideration of the exchange interaction, this model is appropriate across the spectrum from Wannier to Frenkel excitons. The single-particle contributions are obtained from a nearest-neighbor tight-binding model parameterized using the effective mass and spin-orbit coupling. The solutions to the characteristic equation, computed in direct space, are in qualitative agreement with first-principles calculations and highlight the inadequacy of the two-dimensional hydrogen model to describe the lowest-energy exciton bands. The model confirms the lack of subshell degeneracy and shows that the A-B exciton split depends on the electrostatic environment as well as the spin-orbit interaction.
description: 6 pages, 5 figures
Blindness and Visual Impairment in an Urban West African Population: The Tema Eye Survey
Creators: name: Budenz, Donald L.
name: Kim, Hanna
name: Tielsch, James
name: Bandi, Jagadeesh R.
name: Nolan, Winifred
name: Barton, Keith
name: Whiteside-De Vos, Julia
name: Herndon, Leon
name: Hay-Smith, Graham
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To determine the prevalence, etiologies, and risk factors of blindness and visual impairment among persons age 40 years and older residing in an urban West African location.
Three-year Treatment Outcomes in the Ahmed Baerveldt Comparison Study
Creators: name: Costa, Vital P.
name: Buys, Yvonne M.
name: Schiffman, Joyce
name: Godfrey, David G.
name: Barton, Keith
name: Feuer, William J.
name: Budenz, Donald L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: To compare three year outcomes and complications of the Ahmed FP7 Glaucoma Valve (AGV) and Baerveldt 101–350 Glaucoma Implant (BGI) for the treatment of refractory glaucoma.
Sonographic spectrum and postnatal outcomes of early-onset versus late-onset fetal cerebral ventriculomegaly
Creators: name: Bhatia, Anju
name: Thia, Edwin Wee Hong
name: Bhatia, Ashwani
name: Ruochen, Du
name: Yeo, George Seow Heong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: To review the prenatal characteristics and postnatal outcomes of Early-onset and Late-onset cerebral ventriculomegaly (VM). Single-center retrospective study 2013–2017; VM cases grouped into Early-onset VM (EVM; Diagnosis at/before 24 weeks) and Late-onset VM (LVM; Beyond 24 weeks). LVM cases had normal ventricle width measurement at mid-trimester scan. Infection serology, cytogenetics, MRI, sonographic follow-up, perinatal and neurodevelopmental outcomes were analyzed. During the 5-year period, 64,662 women underwent an anomaly screening scan and 302 fetuses were identified with ventriculomegaly; 183 (60.6%) classified as early-onset and 119 (39.4%) LVM. The mean ventricular width was significantly higher in LVM cohort (14.1 mm vs 11.6 mm; p < .01). EVM cases were more often associated with structural anomalies (p < .05). Possible etiologies for EVM were aneuploidy and cerebral malformations like Absent Corpus Callosum, spina bifida, Dandy–Walker malformation, etc., whereas LVM followed aqueductal stenosis, hemorrhage, porencephaly, cerebral tumors, etc. Pregnancy outcomes were available for 251 cases. The pregnancy resulted in more live births in LVM group (87.4% vs 65.6%, p = < .01). Multivariate regression analysis demonstrated additional malformations (p < .0001, OR11.5 [95%CI: 4–35.2]), progression of VM (p = .004, OR 10.2 [95% CI: 2.1–52.3]) and severity of VM (OR 5.3 [95%CI: 0.8–37.7]) were significant predictors of Neurodevelopmental Impairment (NDI). Late gestation at diagnosis was more often associated with NDI (p = .063, OR2.4 [95%CI: 0.9–6.2]), although statistically insignificant. EVM has a significantly different sonographic spectrum and outcomes compared to LVM. EVM is milder and associated with an increased risk of aneuploidy and structural malformations. LVM often occurs secondary to acquired brain lesions.
MPEC 2024-R204 : 2024 RS8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RS8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Five-Year Treatment Outcomes in the Ahmed Baerveldt Comparison Study
Creators: name: Budenz, Donald L.
name: Feuer, William J.
name: Godfrey, David G.
name: Schiffman, Joyce
name: Barton, Keith
name: Buys, Yvonne M.
name: Gedde, Steven J.
name: Costa, Vital P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To compare the five year outcomes of the Ahmed FP7 Glaucoma Valve (AGV) and the Baerveldt 101-350 Glaucoma Implant (BGI) for the treatment of refractory glaucoma.
What do the cosmological supernova data really tell us?
Creators: name: Semiz, İbrahim
name: Çamlıbel, A. Kazım
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Not much by themselves, aparently. We try to reconstruct the scale factor $a(t)$ of the universe from the SNe Ia data, i.e. the luminosity distance $d_{L}(z)$, using only the cosmological principle and the assumption that gravitation is governed by a metric theory. In our hence "model-independent," or "cosmographic" study, we fit functions to $d_{L}(z)$ rather than $a(t)$, since $d_{L}(z)$ is what is measured. We find that the acceleration history of the universe cannot be reliably determined in this approach due to the irregularity and parametrization-dependence of the results. However, adding the GRB data to the dataset cures most of the irregularities, at the cost of compromising the model-independent nature of the study slightly. Then we can determine the redshift of transition to cosmic acceleration as $z_{\rm t} \sim 0.50 \pm 0.09$ for a flat universe (larger for positive spatial curvature). If Einstein gravity (GR) is assumed, we find a redshift at which the density of the universe predicted from the $d_{L}(z)$ data is independent of curvature. We use this point to derive an upper limit on matter density, hence a lower limit on the density of dark energy. While these limits do not improve the generally accepted ones, they are derived *only using the $d_{L}(z)$ data*.
description: 27 regular LaTeX pages, 16 figures, 4 tables
title: Avant-propos
title: La memoria en réflexivité. Naissance d’une philosophie romaine de la mémoire
titleType: Subtitle
Creators: name: Lévy, Carlos
Publisher: name: Classiques Garnier
Year: 2020
Subjects: subject: Épicurisme
subject: Représentation
subject: Sceptique
subject: Sensation
subject: Souvenir

description: Carlos Lévy montre dans son introduction comment à la fin de la République romaine s’élabora une structuration des opinions philosophiques rendant compte de la mémoire. Son rôle est minoré par l’Épicurien Lucrèce, qui semble avoir eu du mal à l’intégrer à son atomisme. Pour les Stoïciens, elle est une trace laissée dans l’hégémonique, sans que pour autant l’éthique cesse de se déployer dans le présent. Cicéron saura dépasser cet immanentisme pour orienter la mémoire vers la transcendance.
D5.3 Maintenance and Legacy for Community Platform
Creators: name: Gértrudix, Manuel
name: Acedo, Alberto Sánchez
name: Romero-Luis, Juan
name: CarbonelL, Alejandro
Publisher: name: Zenodo
Year: 2023
Subjects: citizen science

description: This deliverable submitted at the end of the 34th month of the project shows the results of work carried out over 24 months dedicated to the maintenance and legacy of the CS Track Community Platform published in cstrack.eu To guarantee the sustainability of the Community Platform, this deliverable provides the necessary technical and editorial documentation showing how to use it, including back-up practices, data policy and comprehensive documentation of the legacy of the platform and content published in the eMagazine. To contextualize the legacy information and facilitate the operation of the Community Platform in the future, the document offers a historical review of the actions taken to include successive improvements in the Community Platform to contextualize the updates done, and the result obtained.
Longitudinal changes in peripapillary atrophy in the ocular hypertension treatment study: A case-control assessment
Creators: name: Mwanza, Jean Claude
name: Budenz, Donald L.
name: Vandenbroucke, Ruth
name: Savatovsky, Eleonore
name: Schiffman, Joyce C.
name: Feuer, William J.
name: Anderson, Douglas R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma.