cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(501953) Henry Stillwell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501952) Margaret Elizabeth Stillwell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A flexible method to evolve collisional systems and their tidal debris in external potentials
Creators: name: Renaud, Florent
name: Gieles, Mark
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We introduce a numerical method to integrate tidal effects on collisional systems, using any definition of the external potential as a function of space and time. Rather than using a linearisation of the tidal field, this new method follows a differential technique to numerically evaluate the tidal acceleration and its time derivative. Theses are then used to integrate the motions of the components of the collisional systems, like stars in star clusters, using a predictor-corrector scheme. The versatility of this approach allows the study of star clusters, including their tidal tails, in complex, multi-components, time-evolving external potentials. The method is implemented in the code nbody6 (Aarseth 2003).
description: MNRAS accepted. Code available here: http://personal.ph.surrey.ac.uk/~fr0005/nbody6tt.php
Accumulation and melt dynamics of snowpack from a multiresolution regional climate model in the central Sierra Nevada, California
Creators: name: Kapnick, S.
name: Hall, A.
name: Pavelsky, T.M.
Publisher: name: Blackwell Publishing Ltd
Year: 2011

description: The depth and timing of snowpack in the Sierra Nevada Mountains are of fundamental importance to California water resource availability, and recent studies indicate a shift toward earlier snowmelt consistent with projected impacts of anthropogenic climate change. In order for future studies to assess snowpack variability on seasonal to centennial time scales, physically based models of snowpack evolution at high spatial resolution must be improved. Here we evaluate modeled snowpack accuracy for the central Sierra Nevada in the Weather Research and Forecasting regional climate model coupled to the Noah land surface model. A simulation with nested domains at 27, 9, and 3 km grid spacings is presented for November 2001 to July 2002. Model outputs are compared with daily snowpack observations at 41 locations, air temperature at 31 locations, and precipitation at 10 locations. Comparison of snowpack at different resolutions suggests that 27 km simulations substantially underestimate snowpack, while 9 and 3 km simulations are closer to observations. Regional snowpack accumulation is accurately simulated at these high resolutions, but model snowmelt occurs an average of 22-25 days early. Some error can be traced to differences in elevation and observation scale between point-based measurements and model grid cells, but these factors cannot explain the persistent bias toward early snowmelt. A high correlation between snowmelt and error in modeled surface air temperature is found, with melt coinciding systematically with excessively cold air temperatures. One possible source of bias is an imbalance in turbulent heat fluxes, erroneously warming the snowpack while cooling the surface atmosphere.
Analysis of Bidirectional Ballot Sequences and Random Walks Ending in their Maximum
Creators: name: Hackl, Benjamin
name: Heuberger, Clemens
name: Prodinger, Helmut
name: Wagner, Stephan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A16, 05A15, 05A10, 60C05

description: Consider non-negative lattice paths ending at their maximum height, which will be called admissible paths. We show that the probability for a lattice path to be admissible is related to the Chebyshev polynomials of the first or second kind, depending on whether the lattice path is defined with a reflective barrier or not. Parameters like the number of admissible paths with given length or the expected height are analyzed asymptotically. Additionally, we use a bijection between admissible random walks and special binary sequences to prove a recent conjecture by Zhao on ballot sequences.
Remote sensing of suspended sediment concentration, flow velocity, and lake recharge in the Peace-Athabasca Delta, Canada
Creators: name: Smith, L.C.
name: Pavelsky, T.M.
Publisher: name: Blackwell Publishing Ltd
Year: 2009

description: The transport of fine sediment, carried in suspension by water, is central to the hydrology, geomorphology, and ecological functioning of river floodplains and deltas. An extensive new field data set for the Peace-Athabasca Delta (PAD), Canada quantifies robust positive relationships between in situ suspended sediment concentration (SSC) and remotely sensed visible/near-infrared reflectance. These relationships are exploited using SPOT and ASTER satellite images to map suspended sediment concentrations across the PAD for four days in 2006 and 2007, revealing strong variations in water sources and flow patterns, including flow reversals in major distributaries. Near-daily monitoring with 276 MODIS satellite images tracks hydrologic recharge of floodplain lakes, as revealed by episodic infusions of sediment-rich water from the Athabasca River. The timing and magnitude of lake recharge are linked to springtime water level on the Athabasca River, suggesting a system sensitive to changes in river flow regime. Moreover, recharge timing differentiates lakes that are frequently and extensively recharged from those recharged more rarely. Finally, we present a first estimation of river flow velocity based on remotely sensed SSC, though saturation may occur at velocities >0.6 m/s. Viewed collectively, the different remote sensing methodologies presented here suggest strong value for visible/near-infrared remote sensing of suspended sediment to assess hydrologic and sediment transport processes in complex flow environments. Field observations including nephelometric turbidity, specific conductivity, water temperature, Secchi disk depth, suspended sediment concentration, and water level are archived at the Oak Ridge National Laboratory Distributed Active Archive Center for Biogeochemical Dynamics (available at http://daac.ornl.gov// HYDROCLIMATOLOGY/guides/PAD.html).
ZnO Q-dots as a potent therapeutic nanomedicine for in vitro cytotoxicity evaluation of mouth KB44, breast MCF7, colon HT29 and HeLa cancer cell lines, mouse ear swelling tests in vivo and its side effects using the animal model
Creators: name: Fakhroueian, Zahra
name: Rouhollah Vahabpour
name: Assmar, Mehdi
name: Alireza Massiha
name: Zahedi, Afshin
name: Esmaeilzadeh, Pegah
name: Katouzian, Fatemeh
name: Rezaei, Sara
name: Keyhanvar, Peyman
name: Alireza Mozafari Dehshiri
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plasma Physics

description: Nanoformulations derived from fine porous ZnO quantum dot nanoparticles (QD NPs) can offer strong potential medical applications; especially in cancer therapy. ZnO QD NPs was synthesized by sol–gel hydrothermal process, fast cold quenching and further smart surface functionalization methods to obtain ultrasmall size (1–4 nm) NPs. ZnO nanopolymer, a wetting agent, PEG co-solvent and water/oil emulsion stabilizer were considered in our nanofluid formulation. The resulting nanofluid was characterized by SEM, FTIR, photoluminescence, band gap energy, zeta potential and UV–Vis spectroscopy. The cytotoxic effects on the growth of four cancer cell lines were evaluated by MTT assay. The IC50 (µg/ml) values of 30, 41, 40 and 35 for KB44, MCF-7, HT29 and HeLa cells, respectively, after 48 h of nanoformulation treatment suggested the cytotoxic effect of this nanoformulation on these cell lines in a concentration-dependent manner (p 50 = 105 µg/ml). The reduction in cell viability in response to ZnO nanofluid treatment induced apoptosis in the cultured cells. Skin sensitization test plus antibacterial activity were also measured. Side effect tests on 70 white mice in vivo resulted in only 3–4 abnormal situations in hepatic tissue section possibly due to the idiosyncratic drug reactions.
(501951) Mary-Anne Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Comparison of conventional and advanced in vitro models in the toxicity testing of nanoparticles
Creators: name: Fröhlich, Eleonore
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Humans are exposed to a wide variety of nanoparticles (NPs) present in the environment, in consumer, health and medical products, and in food. Conventional cytotoxicity testing compared to animal testing is less expensive, faster and avoids ethical problems at the expense of a lower predictive value. New cellular models and exposure conditions have been developed to overcome the limitations of conventional cell culture and obtain more predictive data. The use of three-dimensional culture, co-culture and inclusion of mechanical stimulation can provide physiologically more relevant culture conditions. These systems are particularly relevant for oral, respiratory and intravenous exposure to NPs and it may be assumed that physiologically relevant application of the NPs can improve the predictive value of in vitro testing. Various groups have used advanced culture and exposure systems, but few direct comparisons between data from conventional cultures and from advanced systems exist. In silico models may present another option to predict human health risk by NPs without using animal studies. In the absence of validation, the question whether these alternative models provide more predictive data than conventional testing remains elusive.
Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer
Creators: name: Nasrollahi, Parisa
name: Khosro Khajeh
name: Elnaz Tamjid
name: Taleb, Mohammad
name: Soleimani, Masoud
name: Guangjun Nie
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology
subject: 60506 Virology

description: Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA–PEG–PLGA copolymer did not influence its inherent sol–gel transition behaviour, but increased the sol–gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.
(501950) William Frederick Elrington
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Remote sensing of hydrologic recharge in the Peace-Athabasca Delta, Canada
Creators: name: Smith, L.C.
name: Pavelsky, T.M.
Publisher: name: Blackwell Publishing Ltd
Year: 2008

description: Northern wetlands like Canada's Peace-Athabasca Delta (PAD) have global environmental significance, yet fundamental processes of hydrologic recharge critical to their functionality remain poorly understood. We use in situ water level and MODIS satellite data to examine how mainstem river level fluctuations drive inundation across the delta. Temporal covariance between the two datasets allows inference of hydrologic connectivity processes, not just inundation extent. A strong contrast is found between hydrologic connectivity properties in a high-water (2007) vs. low-water year (2006). Results suggest that existing theoretical models of floodplain recharge fail to capture observed patterns of inundation in the PAD. Instead, we find a dichotomy between the distributary channel network, which responds to summer high-water events, and floodplain lakes and wetlands, which do not. The latter occurs even where hydrologic connections do exist between the two. Results have strong management implications for the impact of proposed up-river water diversion on PAD hydrology.
Quark deconfinement and gluon condensate in a weak magnetic field
Creators: name: Ayala, Alejandro
name: Dominguez, C. A.
name: Hernandez, L. A.
name: Loewe, M.
name: Rojas, Juan Cristobal
name: Villavicencio, Cristian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study QCD finite energy sum rules (FESR) for the axial-vector current correlator in the presence of a magnetic field, in the weak field limit and at zero temperature. We find that the perturbative QCD as well as the hadronic contribution to the sum rules get explicit magnetic field-dependent corrections and that these in turn induce a magnetic field dependence on the deconfinement phenomenological parameter s_0 and on the gluon condensate. The leading corrections turn out to be quadratic in the field strength. We find from the dimension d=2 first FESR that the magnetic field dependence of s_0 is proportional to the absolute value of the light-quark condensate. Hence, it increases with increasing field strength. This implies that the parameters describing chiral symmetry restoration and deconfinement behave similarly as functions of the magnetic filed. Thus, at zero temperature the magnetic field is a catalysing agent of both chiral symmetry breaking and confinement. From the dimension d=4 second FESR we obtain the behavior of the gluon condensate in the presence of the external magnetic field. This condensate also increases with increasing field strength.
description: Version accepted to appear in Phys. Rev. D
Building Better Science Diplomacy for Global Challenges: insights from the COVID-19 crisis
Creators: name: Young, Mitchell
Publisher: name: Zenodo
Year: 2020
Subjects: Science Diplomacy

description: The COVID-19 pandemic has exposed many weaknesses in the interface between scientific research and international relations. The pandemic, like other global challenges, is both knowledge-intensive, in that it requires engagement with scientific knowledge for effective policymaking, and cross-border, in that it is not solvable by a single country acting alone. It is an example of what the S4D4C project (Horizon 2020 grant agreement No 770342; Using Science for/in Diplomacy for Addressing Global Challenges) is tasked with helping Europe to understand and address through science diplomacy. Based on a broad range of case study research, the S4D4C project has identified a number of key aspects that matter for science diplomacy.
 In this policy brief, we address four of those (narratives, interests, values, and interdisciplinarity) and discuss their relevance in the COVID-19 crisis. Drawing on these insights, we offer five policy recommendations for expanding and improving future science
 diplomacy efforts: (1) Create interactive spaces, (2) Promote bi-directional science and diplomacy fluency, (3) Engage the full spectrum of science, (4) Ensure open and interpretable science for diplomacy, and (5) Exert bold values-based leadership. In combination, these will create a strong foundation for addressing not only the ongoing issues in this crisis but also other global challenges, both known and unexpected.
description: see https://www.s4d4c.eu/wp-content/uploads/2020/06/S4D4C_PolicyBrief_June2020_BuildingBetterScienceDiplomacy_COVID-19.pdf
Surface engineered lipid nanoparticle-mediated site-specific drug delivery system for the treatment of inflammatory bowel disease
Creators: name: Sinhmar, Gurpreet Kaur
name: Shah, Neel N.
name: Rawal, Shruti U.
name: Nimitt V. Chokshi
name: Hiren N. Khatri
name: Bhoomika M. Patel
name: Mayur M. Patel
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: The major challenge for the treatment of inflammatory bowel disease (IBD) is the incompetence to deliver the drug molecule selectively at the site of inflammation. Taking this into consideration, we proposed development of mannosylated nanostructured lipid carrier system (Mn-NLCs) for active targeting and site-specific delivery of budesonide to the inflamed tissues. The developed Mn-NLCs were characterized for particle size and size distribution, zeta potential, %entrapment efficiency, FTIR and TEM analysis. Furthermore, to ensure delivery of developed cargo to the colonic region, the Mn-NLCs were encapsulated using Eudragit® S100 coated pellets. The in vivo evaluation of developed system was performed by employing oxazolone colitis rat model. The average particle size of Mn-NLCs (301.7 ± 2.88 nm) was found to be more than that of unconjugated NLCs (284.0 ± 4.53 nm) with marginally reduced % entrapment efficiency (90.88 ± 3.86%). The in vitro cytotoxicity studies using J774A.1 cell line revealed that Mn-NLCs were non-toxic as compared to pure drug. The in vivo evaluation depicted that Mn-NLCs showed significant reduction in clinical activity scoring, macroscopic and microscopic indexing, colonic myeloperoxidase activity and inflammatory cytokines. In conclusion, the developed Mn-NLCs appear to be promising for the treatment of IBD by selectively targeting inflamed colonic region as compared to unconjugated nanoparticulate system.
(501949) ____ ? [Mansell]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Unlocking the Use of Raw Multispectral Earth Observation Imagery for Onboard Artificial Intelligence
Creators: name: Meoni, Gabriele
name: Del Prete, Roberto
name: Serva, Federico
name: De Beussche, Alix
name: Colin, Olivier
name: Longépé, Nicolas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Nowadays, there is growing interest in applying Artificial Intelligence (AI) on board Earth Observation (EO) satellites for time-critical applications, such as natural disaster response. However, the unavailability of raw satellite data currently hinders research on lightweight pre-processing techniques and limits the exploration of end-to-end pipelines, which could offer more efficient and accurate extraction of insights directly from the source data. To fill this gap, this work presents a novel methodology to automate the creation of datasets for the detection of target events (e.g., warm thermal hotspots) or objects (e.g., vessels) from Sentinel-2 raw data and other multispectral EO pushbroom raw imagery. The presented approach first processes the raw data by applying a pipeline consisting of spatial band registration and georeferencing of the raw data pixels. Then, it detects the target events by leveraging event-specific state-of-the-art algorithms on the Level-1C products, which are mosaicked and cropped on the georeferenced correspondent raw granule area. The detected events are finally re-projected back onto the corresponding raw images. We apply the proposed methodology to realize THRawS (Thermal Hotspots in Raw Sentinel-2 data), the first dataset of Sentinel-2 raw data containing warm thermal hotspots. THRawS includes 1090 samples containing wildfires, volcanic eruptions, and 33,335 event-free acquisitions to enable thermal hotspot detection and general classification applications. This dataset and associated toolkits provide the community with both an immediately useful resource as well as a framework and methodology acting as a template for future additions. With this work, we hope to pave the way for research on energy-efficient pre-processing algorithms and AI-based end-to-end processing systems on board EO satellites.
description: 17 Pages
Increasing the stability of Lumbricus terrestris erythrocruorin via poly(acrylic acid) conjugation
Creators: name: Spivack, Kyle
name: Tucker, Matthew
name: Zimmerman, Devon
name: Nicholas, Matthew
name: Osheiza Abdulmalik
name: Comolli, Noelle
name: Elmer, Jacob
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Hematology

description: Since donated red blood cells must be constantly refrigerated, they are often unavailable in remote areas and battlefields. The goal of this study was to synthesize a highly stable blood substitute that does not require refrigeration. Specifically, the extracellular haemoglobin (a.k.a. erythrocruorin, Ec) of the earthworm Lumbricus terrestris erythrocruororin (LtEc) was cross-linked with poly(acrylic acid) (PAA) and ethylene diamine (EDA). PAGE analysis of the LtEc nanoparticles reveals cross-linking between subunits, while dynamic light scattering and scanning electron microscopy show that cross-linking significantly increases the size of the LtEc nanoparticles (164 ± 13.9 nm). Cross-linking also significantly increased the thermal stability of the LtEc nanoparticles by 10 °C (Tm = 72 ± 0.84 °C) relative to native LtEc (Tm = 62 ± 0.6 °C). In addition, while native LtEc rapidly dissociates at pH 9, the LtEc nanoparticles resist subunit dissociation up to pH 10. The oxygen affinity of the LtEc nanoparticles (P50 = 6.85 ± 0.13 mm Hg) is much higher than native LtEc (P50 = 26.67 ± 0.4 mm Hg), but the cooperativity (n = 2.43 ± 0.12) is not affected. Altogether, these results show that cross-linking LtEc with PAA and EDA provides a potential blood substitute with increased stability and oxygen affinity.
Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD
Creators: name: Shuying He
name: Weihong Guo
name: Feihong Deng
name: Kequan Chen
name: Yonghong Jiang
name: Minyu Dong
name: Peng, Liang
name: Xueqing Chen
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, and precision therapeutic will be a benefit for the NAFLD regression. In this study, we observed low microRNA 146 b (miR-146 b) expression in NAFLD mice model induced by methionine–choline-deficient diet (MCD) compared with control group. Furthermore, miR-146b−/− mice induced MCD exhibited severe liver steatosis and hepatitis. A bio-distribution study showed that novel Lactosylated PDMAEMA nanoparticles effectively targeted hepatocytes Lac-PDMAEMA. We coupled miR-146b mimic with Lac-PDMAEMA and then were administrated to NAFLD mice model, which could obviously alleviate the hepatic steatosis. Lac-PDMAEMA effectively delivered miR-146b mimic to hepatocytes with a ∼8-fold upregulation of miR-146b mimic targeting MyD88 and IRAK1, and in turn suppressed the expression of PPARγ. Meanwhile, TNF-α and IL-6 mRNA levels were decreased after administration of Lac-PDMAEMA/miR-146b mimic. So, we made a conclusion that targeted delivering miR-146b mimic to the hepatocytes by, coupling Lac-PDMAEMA nanoparticles could effectively alleviate the hepatic steatosis in NAFLD mice, which maybe bring a new and effective way to intervene and therapy the NAFLD.
Is inner core seismic anisotropy a marker of plastic flow of cubic iron?
Creators: name: Lincot, A.
name: Merkel, S.
name: Cardin, Philippe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geophysics (physics.geo-ph)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: This paper investigates whether observations of seismic anisotropy are compatible with a cubic structure of the inner core Fe alloy. We assume that anisotropy is the result of plastic deformation within a large scale flow induced by preferred growth at the inner core equator. Based on elastic moduli from the literature, bcc- or fcc-Fe produce seismic anisotropy well below seismic observations ($\textless{}0.4\%$). A Monte-Carlo approach allows us to generalize this result to any form of elastic anisotropy in a cubic system. Within our model, inner core global anisotropy is not compatible with a cubic structure of Fe alloy. Hence, if the inner core material is indeed cubic, large scale coherent anisotropic structures, incompatible with plastic deformation induced by large scale flow, must be present.
(501948) Walter Mansell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The 4D Camera: an 87 kHz direct electron detector for scanning/transmission electron microscopy
Creators: name: Ercius, Peter
name: Johnson, Ian J.
name: Pelz, Philipp
name: Savitzky, Benjamin H.
name: Hughes, Lauren
name: Brown, Hamish G.
name: Zeltmann, Steven E.
name: Hsu, Shang-Lin
name: Pedroso, Cassio C. S.
name: Cohen, Bruce E.
name: Ramesh, Ramamoorthy
name: Paul, David
name: Joseph, John M.
name: Stezelberger, Thorsten
name: Czarnik, Cory
name: Lent, Matthew
name: Fong, Erin
name: Ciston, Jim
name: Scott, Mary C.
name: Ophus, Colin
name: Minor, Andrew M.
name: Denes, and Peter
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We describe the development, operation, and application of the 4D Camera -- a 576 by 576 pixel active pixel sensor for scanning/transmission electron microscopy which operates at 87,000 Hz. The detector generates data at approximately 480 Gbit/s which is captured by dedicated receiver computers with a parallelized software infrastructure that has been implemented to process the resulting 10 - 700 Gigabyte-sized raw datasets. The back illuminated detector provides the ability to detect single electron events at accelerating voltages from 30 - 300 keV. Through electron counting, the resulting sparse data sets are reduced in size by 10 - 300x compared to the raw data, and open-source sparsity-based processing algorithms offer rapid data analysis. The high frame rate allows for large and complex 4D-STEM experiments to be accomplished with typical STEM scanning parameters.
(501947) Thomas Chopping
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Octa-arginine modified poly(amidoamine) dendrimers for improved delivery and cytotoxic effect of paclitaxel in cancer
Creators: name: Rompicharla, Sri Vishnu Kiran
name: Kumari, Preeti
name: Balaram Ghosh
name: Biswas, Swati
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology

description: Cell penetrating peptides (CPP) have the ability to penetrate the cell membrane and have been associated with various cargos for their facile intracellular translocation. The current study involves the synthesis of a CPP, octa-arginine (R8)-modified poly(amidoamine) dendrimer of generation 4 (G4), which has additionally been PEGylated and conjugated to the poorly soluble anticancer drug, paclitaxel (PTX). The synthesized dendrimer conjugates were characterized by proton nuclear magnetic resonance (1H-NMR) Spectroscopy and zeta potential measurements and evaluated in vitro in cell monolayers and 3D spheroids. Cellular uptake study in human cervical cancer cell line (HeLa) revealed that R8 modification significantly improved the cell association of conjugates. G4-PTX- polyethylene glycol (PEG)-R8 conjugate demonstrated enhanced cytotoxic potential and higher induction of apoptosis compared to free PTX and G4-PTX-PEG. Further, the penetrability of fluorescently labeled F-G4-PTX-PEG-R8 was evaluated in 3D spheroids of HeLa at various depths by using confocal microscopy. G4-PTX-PEG-R8 induced cell death and inhibited the growth in 3D spheroids as competently as in monolayers. The enhanced intracellular translocation of R8-modified dendrimers resulted in improved anticancer efficacy of PTX. Therefore, the newly developed dendrimer system is efficient for the intracellular delivery of PTX in cancer cells and has a strong potential to be utilized as an effective chemotherapeutic agent for cancer.
On the Identifiablility of Nonlocal Interaction Kernels in First-Order Systems of Interacting Particles on Riemannian Manifolds
Creators: name: Tang, Sui
name: Tuerkoen, Malik
name: Zhou, Hanming
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: Classical Analysis and ODEs (math.CA)
subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 70F17, 62G05, 62J05

description: In this paper, we tackle a critical issue in nonparametric inference for systems of interacting particles on Riemannian manifolds: the identifiability of the interaction functions. Specifically, we define the function spaces on which the interaction kernels can be identified given infinite i.i.d observational derivative data sampled from a distribution. Our methodology involves casting the learning problem as a linear statistical inverse problem using a operator theoretical framework. We prove the well-posedness of inverse problem by establishing the strict positivity of a related integral operator and our analysis allows us to refine the results on specific manifolds such as the sphere and Hyperbolic space. Our findings indicate that a numerically stable procedure exists to recover the interaction kernel from finite (noisy) data, and the estimator will be convergent to the ground truth. This also answers an open question in [MMQZ21] and demonstrate that least square estimators can be statistically optimal in certain scenarios. Finally, our theoretical analysis could be extended to the mean-field case, revealing that the corresponding nonparametric inverse problem is ill-posed in general and necessitates effective regularization techniques.
description: 21 pages, 2 figures
title: Book review : The Children of Looked After Children: Outcomes, Experiences and Ensuring Meaningful Support to Young Parents In and Leaving Care by Louise Roberts
Creators: name: Young, Emma
Publisher: name: Strathprints - University of Strathclyde
Year: 2022

description: Published in March 2021, The Children of Looked After Children draws together findings from a four and a half year research study looking at parents in and leaving care in Wales. Funded by Health and Care Research Wales, the research was undertaken by Dr Louise Roberts within the Children's Social Care Research and Development Centre (CASCADE) at Cardiff University.
(501509) Elizabeth [Hunt]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
De-esterified tragacanth-chitosan nano-hydrogel for methotrexate delivery; optimization of the formulation by Taguchi design
Creators: name: Komail Sadrjavadi
name: Shahbazi, Behzad
name: Fattahi, Ali
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The objective of the present study was to prepare and characterized de-esterified tragacanth-chitosan nanoparticles (DET-CS NPs) as a novel carrier for methotrexate, with a view to improve drug efficacy and target ability. The preparation process was optimized using Taguchi design. NPs were characterized for size, zeta potential, morphology, thermal stability, loading efficiency, cytotoxicity and cellular uptake. Taguchi design indicated that the molecular weight of chitosan possessed the most effect on the zeta potential, PDI, and zeta deviation, and the size of nanoparticles was significantly affected by the DET concentration. The size and zeta potential of drug loaded nanoparticles at optimum condition were 322.9 ± 26 nm and 17.3 ± 5.73 mV, and thermal analysis indicated ionic bond between DET and CS in NPs. The loading efficiency was 20.32% ± 2.01, and the sustained release was observed within nine days. The IC50 was 280 µg/mL in HT-29, and the mitochondrial membrane potential in HT-29 was reduced more than that in MCF-7. The uptake of NPs in HT-29 was higher than that in MCF-7, and active endocytosis was the key mechanism of uptake. These phenomena altogether make DET-CS NPs a proper choice for targeted drug delivery to cells containing asialoglycoprotein receptors.
Estimation of river discharge, propagation speed, and hydraulic geometry from space: Lena River, Siberia
Creators: name: Smith, L.C.
name: Pavelsky, T.M.
Publisher: name: Blackwell Publishing Ltd
Year: 2008

description: Moderate Resolution Imaging Spectroradiometer (MODIS)-derived measurements of Lena River effective width (We) display a high predictive capacity (r2 = 0.81, mean absolute error < 25%) to forecast downstream discharge conditions at Kusur station, some 8 d and ∼700 km later. Satellite-derived mean flow propagation speed (88 km d-1 or 1.01 m s-1) compares well with that estimated from ground data (84 km d -1 or 0.97 m s-1). Scaling analysis of a ∼300 km heavily braided study reach suggests that at length scales > 60-90 km (∼2-3 time valley width), satellite-derived We - Q rating curves and hydraulic geometry (b exponents) converge upon stable values (b = 0.48), indicating transferability of the discharge retrieval method between different locations. Put another way, at length scales exceeding ∼60-90 km all subreaches display similar behavior everywhere. At finer reach length scales (e.g., 0.25-1 km), longitudinal extraction of b exponents represents the first continuous mapping of a classical hydraulic geometry parameter from space. While at least one gauging station is required for calibration, results suggest that multitemporal satellite data can powerfully enhance our understanding of water discharge and flow conveyance in remote river systems.
(501508) John Hunt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synergic highly effective photothermal-chemotherapy with platinum prodrug linked melanin-like nanoparticles
Creators: name: Chengwei Zhang
name: Xiaozhi Zhao
name: Hongqian Guo
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Cisplatin is widely used in cancer treatment, but the application is limited due to toxicities and its acquired resistance. In this study, we delivered cisplatin to prostate cancer cells by linking the platinum prodrug Pt(IV) to melanin-like nanoparticles (MeNPs), a promising photothermal therapeutic agent with excellent biocompatibility. As expected, the Pt(IV)-MeNPs exhibited brilliant synergic photothermal-chemotherapy upon near-infrared reflection exposure. Compared with free cisplatin, Pt(IV)-MeNPs displayed highly effective antitumour activity both in vitro and in vivo.
(501507) Ann Hunt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nucleon spin structure
Creators: name: Zhu, Wei
name: Ruan, Jianhong
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: This paper contains three parts relating to the nucleon spin structure in a simple picture of the nucleon: (i) The polarized gluon distribution in the proton is dynamically predicted starting from a low scale by using a nonlinear QCD evolution equation-the DGLAP equation with the parton recombination corrections, where the nucleon is almost only consisted of valence quarks. We find that the contribution of the gluon polarization to the nucleon spin structure is much larger than the predictions of most other theories. This result suggests a significant orbital angular momentum of the gluons is required to balance the gluon spin momentum; (ii) The spin structure function $g_1^p$ of the proton is studied, where the perturbative evolution of parton distributions and nonperturbative Vector Meson Dominance (VMD) model are used. We predict $g_1^p$ asymptotic behavior at small $x$ from lower $Q^2$ to higher $Q^2$. The results are compatible with the data including the HERA early estimations and COMPASS new results; (iii) The generalized Gerasimov-Drell-Hearn (GDH) sum rule is understood based on the polarized parton distributions of the proton with the higher twist contributions. A simple parameterized formula is proposed to clearly present the contributions of different components in the proton to $Γ_1^p(Q^2)$. The results suggest a possible extended objects with size $0.2-0.3~ fm$ inside the proton.
description: 46 pages. 26 figures
COLDz: Karl G. Jansky Very Large Array discovery of a gas-rich galaxy in COSMOS
Creators: name: Lentati, L.
name: Wagg, J.
name: Carilli, C. L.
name: Riechers, D.
name: Capak, P.
name: Walter, F.
name: Aravena, M.
name: da Cunha, E.
name: Hodge, J. A.
name: Ivison, R. J.
name: Smail, I.
name: Sharon, C.
name: Daddi, E.
name: Decarli, R.
name: Dickinson, M.
name: Sargent, M.
name: Scoville, N.
name: Smolcic, V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The broad spectral bandwidth at mm and cm-wavelengths provided by the recent upgrades to the Karl G. Jansky Very Large Array (VLA) has made it possible to conduct unbiased searches for molecular CO line emission at redshifts, z > 1.31. We present the discovery of a gas-rich, star-forming galaxy at z = 2.48, through the detection of CO(1-0) line emission in the COLDz survey, through a sensitive, Ka-band (31 to 39 GHz) VLA survey of a 6.5 square arcminute region of the COSMOS field. We argue that the broad line (FWHM ~570 +/- 80 km/s) is most likely to be CO(1-0) at z=2.48, as the integrated emission is spatially coincident with an infrared-detected galaxy with a photometric redshift estimate of z = 3.2 +/- 0.4. The CO(1-0) line luminosity is L'_CO = (2.2 +/- 0.3) x 10^{10} K km/s pc^2, suggesting a cold molecular gas mass of M_gas ~ (2 - 8)x10^{10}M_solar depending on the assumed value of the molecular gas mass to CO luminosity ratio alpha_CO. The estimated infrared luminosity from the (rest-frame) far-infrared spectral energy distribution (SED) is L_IR = 2.5x10^{12} L_solar and the star-formation rate is ~250 M_solar/yr, with the SED shape indicating substantial dust obscuration of the stellar light. The infrared to CO line luminosity ratio is ~114+/-19 L_solar/(K km/s pc^2), similar to galaxies with similar SFRs selected at UV/optical to radio wavelengths. This discovery confirms the potential for molecular emission line surveys as a route to study populations of gas-rich galaxies in the future.