cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Patient education improves pain and function in people with knee osteoarthritis with better effects when combined with exercise therapy: a systematic review
Creators: name: Goff, Anthony
name: De-Oliveira-Silva, Danilo
name: Merolli, M
name: Bell, Emily
name: Crossley, Kay
name: Barton, Christian
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Question: Is patient education effective as a standalone intervention or combined with other interventions for people with knee osteoarthritis? Design: Systematic review of randomised controlled trials. MEDLINE, EMBASE, SPORTDiscus, CINAHL and Web of Science were searched from inception to April 2020. The Cochrane Risk of Bias tool was used for included studies, and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was used to interpret certainty of results. Participants: People with knee osteoarthritis. Intervention: Any patient education intervention compared with any non-pharmacological comparator. Outcome measures: Primary outcomes were self-reported pain and function. Results: Twenty-nine trials involving 4,107 participants were included, informing low to very-low certainty evidence. Nineteen of 28 (68%) pooled comparisons were not statistically significant. Patient education was superior to usual care for pain (SMD −0.35, 95% CI −0.56 to −0.14) and function in the short term (−0.31, 95% CI −0.62 to 0.00), but inferior to exercise therapy for pain in the short term (0.77, 95% CI 0.07 to 1.47). Combining patient education with exercise therapy produced superior outcomes compared with patient education alone for pain in the short term (0.44, 95% CI 0.19 to 0.69) and function in the short (0.81, 95% CI 0.54 to 1.08) and medium term (0.39, 95% CI 0.15 to 0.62). When using the Western Ontario and McMaster Universities Osteoarthritis Index for these comparisons, clinically important differences indicated that patient education was inferior to exercise therapy for pain in the short term (MD 1.56, 95% CI 0.14 to 2.98) and the combination of patient education and exercise therapy for function in the short term (8.94, 95% CI 6.05 to 11.82). Conclusion: Although patient education produced statistically superior short-term pain and function outcomes compared with usual care, differences were small and may not be clinically important. Patient education should not be provided as a standalone treatment and should be combined with exercise therapy to provide statistically superior and clinically important short-term improvements in function compared with education alone. Registration: PROSPERO CRD42019122004.
Experimental demonstration of Gaussian boson sampling with displacement
Creators: name: Thekkadath, G. S.
name: Sempere-Llagostera, S.
name: Bell, B. A.
name: Patel, R. B.
name: Kim, M. S.
name: Walmsley, I. A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Gaussian boson sampling (GBS) is quantum sampling task in which one has to draw samples from the photon-number distribution of a large-dimensional nonclassical squeezed state of light. In an effort to make this task intractable for a classical computer, experiments building GBS machines have mainly focused on increasing the dimensionality and squeezing strength of the nonclassical light. However, no experiment has yet demonstrated the ability to displace the squeezed state in phase-space, which is generally required for practical applications of GBS. In this work, we build a GBS machine which achieves the displacement by injecting a laser beam alongside a two-mode squeezed vacuum state into a 15-mode interferometer. We focus on two new capabilities. Firstly, we use the displacement to reconstruct the multimode Gaussian state at the output of the interferometer. Our reconstruction technique is in situ and requires only three measurements settings regardless of the state dimension. Secondly, we study how the addition of classical laser light in our GBS machine affects the complexity of sampling its output photon statistics. We introduce and validate approximate semi-classical models which reduce the computational cost when a significant fraction of the detected light is classical.
description: 11 pages, 11 figures
Effects of Temperature and Magnetization on the Mott-Anderson Physics in one-dimensional Disordered Systems
Creators: name: Canella, G. A.
name: Zawadzki, K.
name: França, V. V.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate the Mott-Anderson physics in interacting disordered one-dimensional chains through the average single-site entanglement quantified by the linear entropy, which is obtained via density-functional theory calculations. We show that the minimum disorder strength required to the so-called full Anderson localization $-$ characterized by the real-space localization of pairs $-$ is strongly dependent on the interaction regime. The degree of localization is found to be intrinsically related to the interplay between the correlations and the disorder potential. In magnetized systems, the minimum entanglement characteristic of the full Anderson localization is split into two, one for each of the spin species. We show that although all types of localization eventually disappear with increasing temperature, the full Anderson localization persists for higher temperatures than the Mott-like localization.
Physical testing characteristics better explain draft outcome than in-game movement profile in junior elite Australian rules football players
Creators: name: Jennings, Jacob
name: Wundersitz, Daniel
name: Sullivan, Courtney
name: Cousins, Stephen
name: Tehan, G
name: Kingsley, Michael
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4207
subject: Sports science and exercise
classificationCode: 5201
subject: Applied and developmental psychology

description: No
description supplied
Observing true tauonium via two-photon fusion at $e^+e^-$ and hadron colliders
Creators: name: d'Enterria, David
name: Shao, Hua-Sheng
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The feasibility of observing true tauonium, the bound state of two tau leptons, $\mathcal{T}_0\equiv(τ^+τ^-)_0$, via photon-photon collisions at $e^+e^-$ colliders and at the LHC, is studied. The production cross sections of the process $γγ\to\mathcal{T}_0\toγγ$ -- as well as those of all relevant backgrounds: spin-0 and 2 charmonium resonances decaying to diphotons, and light-by-light scattering -- are computed in the equivalent photon approximation for $e^+e^-$ collisions at BES III ($\sqrt{s} = 3.8$ GeV), Belle II ($\sqrt{s} = 10.6$ GeV), and FCC-ee ($\sqrt{s} = 91.2$ GeV), as well as for ultraperipheral p-p, p-Pb, and Pb-Pb collisions at the LHC. Despite small $\mathcal{T}_0$ production cross sections and a final state swamped by decays from overlapping pseudoscalar and tensor charmonium states -- the $\mathrm{χ_{c2}}$, $\mathrm{η_{c}(2S)}$, and $\mathrm{χ_{c0}}$ states have masses only 2.5, 84, and 139 MeV away, respectively, from the $\mathcal{T}_0$ peak -- evidence and observation of the ground state of the heaviest leptonium appears feasible at Belle II and FCC-ee, respectively, with in-situ high-precision measurements of the irreducible backgrounds.
description: 8 pages, 5 figures. Minor corrections. Matches published version
Resumen de las Actas de la Comisión de Monumentos y Patrimonio Histórico Acta nº1 de 13 de enero de 2025
Creators: name: Moleón Gavilanes, Pedro
name: Almagro Gorbea, Antonio
name: Nieto Yusta, Olivia
Publisher: name: Real Academia de Bellas Artes de San Fernando
Year: 2025

description: RESUMEN DE LAS ACTAS DE LA COMISIÓN DE MONUMENTOS Y PATRIMONIO HISTÓRICO

ACTA Nº 1 DE 13 DE ENERO DE 2025

En la Comisión de Monumentos y Patrimonio Histórico celebrada el 13 de enero de 2025 se abordaron los siguientes asuntos: 

- Balance anual de la Comisión de Monumentos y Patrimonio Histórico del año 2024. 

- Proyecto del yacimiento arqueológico del arrabal andalusí de la Arrixaca, Murcia.

- Iniciativa “Monumento a la Infancia expósita de Asturias”.

 -Tapiz flamenco conservado en la catedral de Tarragona.

- Impacto patrimonial sobre el Paisaje Cultural de Aranjuez.

- Transformación del edificio ubicado en la calle Cardiles nº 10 de León, obra del arquitecto Juan Crisóstomo Torbado y en la que intervino el ceramista Daniel Zuloaga.

- Proyecto de rehabilitación del edificio neomudéjar de la calle Alcázar de Toledo, nº 11, en León.

- Mostrador de la recepción del Hostal de San Marcos, actual Parador de Turismo de León, realizado por Lucio Muñoz.
Supplementary document for Opto-thermoelectric trapping of Fluorescent Nanodiamonds on Plasmonic Nanostructures - 6403639.pdf
Creators: name: Shukla, Ashutosh
name: Tiwari, Sunny
name: Majumdar, Ayan
name: Saha, Kasturi
name: Kumar, G V Pavan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Optical Physics not elsewhere classified

description: Supplementary information
HARMONY: a pragmatic cluster randomised controlled trial of a culturally competent systems intervention to prevent and reduce domestic violence among migrant and refugee families in general practice: study protocol
Creators: name: Taft, Angela
name: Young, Felicity
name: Hegarty, Kelsey
name: Yelland, Jane
name: Mazza, Danielle
name: Boyle, Douglas
name: Norman, Richard
name: Garcia-Moreno, Claudia
name: Nguyen, Cattram Duong
name: Li, Xia
name: Pokharel, Bijaya
name: Allen, Molly
name: Feder, Gene
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: IntroductionDomestic violence and abuse (DVA) is prevalent, harmful and more dangerous among diaspora communities because of the difficulty accessing DVA services, language and migration issues. Consequently, migrant/refugee women are common among primary care populations, but evidence for culturally competent DVA primary care practice is negligible. This pragmatic cluster randomised controlled trial aims to increase DVA identification and referral (primary outcomes) threefold and safety planning (secondary outcome) among diverse women attending intervention vs comparison primary care clinics. Additionally, the study plans to improve recording of DVA, ethnicity, and conduct process and economic evaluations.Methods and analysisRecruitment of ≤28 primary care clinics in Melbourne, Australia with high migrant/refugee communities. Eligible clinics need ≥1 South Asian general practitioner (GP) and one of two common software programmes to enable aggregated routine data extraction by GrHanite. Intervention staff undertake three DVA training sessions from a GP educator and bilingual DVA advocate/educator. Following training, clinic staff and DVA affected women 18+ will be supported for 12 months by the advocate/educator. Comparison clinics are trained in ethnicity and DVA data entry and offer routine DVA care. Data extraction of DV identification, safety planning and referral from routine GP data in both arms. Adjusted regression analysis by intention-to-treat by staff blinded to arm. Economic evaluation will estimate cost-effectiveness and cost–utility. Process evaluation interviews and analysis with primary care staff and women will be framed by Normalisation Process Theory to maximise understanding of sustainability. Harmony will be the first primary care trial to test a culturally competent model for the care of diverse women experiencing DVA.
title: “With All Her Sad Disasters, What Do We See in This City?”: Reconstruction, Race, and the Politics of Disaster in Richmond, 1870-1920
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Disaster studies
subject: Race
subject: Reconstruction
subject: Richmond
subject: American history

description: In 1870, Richmond, the former capital of the Confederacy, endured three disasters. On 27 April, over sixty people died when the Capitol courtroom gallery and floor collapsed. The James River flooded on 30 September, resulting in thousands of dollars of damage. Eight people perished when the Spotswood Hotel caught fire on 25 December. This dissertation examines how Richmonders experienced, responded to, and remembered the 1870 calamities, as well as how the disasters affected a community in a time of extreme political and racial upheaval. The five years following the end of the Civil War represented a time of hope for many Black Richmonders, while some white Richmonders viewed Radical Reconstruction as a threat to white supremacy. Richmonders’ responses to the disasters were shaped by the political and racial contexts in which they occurred: despite significant tensions between white and Black Richmonders, journalists perpetuated a false narrative of racial harmony between the two communities; after the flood decimated the primarily Black neighborhood of Rocketts, few reporters detailed their suffering; and the Spotswood Hotel fire victims received less laudatory press coverage because they were poorer and less socially prominent than the Capitol disaster dead. Northerners provided aid to their former enemies in the wake of the Capitol disaster, prefiguring eventual reconciliation between the North and South. Lost Cause adherents later co-opted the Capitol disaster and argued that it exemplified the failure of Reconstruction.
A self-adaptive system of systems architecture to enable its ad-hoc scalability: Unmanned Vehicle Fleet -- Mission Control Center Case study
Creators: name: Sadik, Ahmed R.
name: Bolder, Bram
name: Subasic, Pero
Publisher: name: arXiv
Year: 2024
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: Software Engineering (cs.SE)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: A System of Systems (SoS) comprises Constituent Systems (CSs) that interact to provide unique capabilities beyond any single CS. A key challenge in SoS is ad-hoc scalability, meaning the system size changes during operation by adding or removing CSs. This research focuses on an Unmanned Vehicle Fleet (UVF) as a practical SoS example, addressing uncertainties like mission changes, range extensions, and UV failures. The proposed solution involves a self-adaptive system that dynamically adjusts UVF architecture, allowing the Mission Control Center (MCC) to scale UVF size automatically based on performance criteria or manually by operator decision. A multi-agent environment and rule management engine were implemented to simulate and verify this approach.
description: 2023 7th International Conference on Intelligent Systems, Metaheuristics & Swarm Intelligence (ISMSI 2023)
title: Exploring source credibility and message theme impacts: Developing e-cigarette health messages for college students
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: Electronic cigarettes (e-cigarettes) are battery powered devices that deliver nicotine through vapor, which is inhaled by users and known as vaping. E-cigarette use has increased rapidly among young adults, raising over 46% between 2013-2018 (Dai & Leventhal, 2019). Problematically, there is conflicting information regarding the risks of e-cigarettes. Some scholars argue that e-cigarettes are effective tools for assisting in the cessation of cigarette smoking (Du et al., 2020) while other research points to the numerous health harms associated with vaping (Glynn et al., 2021). Health campaigns have been effective at preventing youth and young adults from initiating tobacco use (Xuan & Choi, 2021; Zeller, 2020) and could serve as inoculation against misinformation about the harms of vaping (Katz et a., 2020). However, further research is needed to better understand which sources young adults trust for e-cigarette information and which message themes are effective at preventing e-cigarette initiation. An experimental survey design tested four message sources and four message themes with college students to determine perceived credibility, perceived message effectiveness, and which messages increased willingness to communicate about health, self-efficacy, and behavioral intentions to avoid e-cigarette use. Results showed that government and public health agency’s health campaigns were viewed as credible sources. Further, the nicotine message theme was perceived as more credible when compared to the health, ingredients, and uncertainty themes. Practical implications for health campaign developers are discussed.
HARMONY: a pragmatic cluster randomised controlled trial of a culturally competent systems intervention to prevent and reduce domestic violence among migrant and refugee families in general practice: study protocol
Creators: name: Taft, Angela
name: Young, Felicity
name: Hegarty, Kelsey
name: Yelland, Jane
name: Mazza, Danielle
name: Boyle, Douglas
name: Norman, Richard
name: Garcia-Moreno, Claudia
name: Nguyen, Cattram Duong
name: Li, Xia
name: Pokharel, Bijaya
name: Allen, Molly
name: Feder, Gene
Publisher: name: La Trobe
Year: 2021

description: IntroductionDomestic violence and abuse (DVA) is prevalent, harmful and more dangerous among diaspora communities because of the difficulty accessing DVA services, language and migration issues. Consequently, migrant/refugee women are common among primary care populations, but evidence for culturally competent DVA primary care practice is negligible. This pragmatic cluster randomised controlled trial aims to increase DVA identification and referral (primary outcomes) threefold and safety planning (secondary outcome) among diverse women attending intervention vs comparison primary care clinics. Additionally, the study plans to improve recording of DVA, ethnicity, and conduct process and economic evaluations.Methods and analysisRecruitment of ≤28 primary care clinics in Melbourne, Australia with high migrant/refugee communities. Eligible clinics need ≥1 South Asian general practitioner (GP) and one of two common software programmes to enable aggregated routine data extraction by GrHanite. Intervention staff undertake three DVA training sessions from a GP educator and bilingual DVA advocate/educator. Following training, clinic staff and DVA affected women 18+ will be supported for 12 months by the advocate/educator. Comparison clinics are trained in ethnicity and DVA data entry and offer routine DVA care. Data extraction of DV identification, safety planning and referral from routine GP data in both arms. Adjusted regression analysis by intention-to-treat by staff blinded to arm. Economic evaluation will estimate cost-effectiveness and cost–utility. Process evaluation interviews and analysis with primary care staff and women will be framed by Normalisation Process Theory to maximise understanding of sustainability. Harmony will be the first primary care trial to test a culturally competent model for the care of diverse women experiencing DVA.
An Objective Material Selection Metric for Acoustic Guitar Soundboards
Creators: name: Pessler, Devon J
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 401702
subject: Dynamics, vibration and vibration control
classificationCode: 401706
subject: Numerical modelling and mechanical characterisation
classificationCode: 300799
subject: Forestry sciences not elsewhere classified

description: Acoustic guitar soundboard material selection is based on selective evaluations that have been developed over centuries. These traditional practices are not conducive to the guitar industry we experience today because the supply of traditionally acceptable soundboard wood has decreased greatly. The purpose of this research was to develop an objective wood selection metric to determine the sound quality of an acoustic guitar’s soundboard. The metric would replace the subjective evaluations traditionally used to select materials for acoustic guitar soundboards.The acoustic properties of sound radiation coefficient, material’s speed of sound, resonance and damping and the material properties of longitudinal and radial elastic modulus, density, and specific modulus were used in an attempt to construct a material selection metric. These variables were selected because the literature review revealed that these were the most critical variables in determining sound quality. The gaps in the literature were testing and analyzing samples that represented the true dimensions of an acoustic guitar soundboard blank and forming the metric. The literature revealed that the previous experimental studies did not have the appropriate test sample dimensions that correspond to the test samples evaluated by the subjective methods.The methodology was carried out by using the objective testing counterparts to the subjective assessments found in the literature review. Instrumented hammer tap testing collected data to determine damping and resonance frequencies. A three-point static bending test collected data for longitudinal and radial elastic modulus. Mass and dimension measurements were recorded to calculate density. Calculations were done to compute the acoustic properties and specific modulus of the test samples. These variables were put into a table and underwent statistical analysis in the form of predictor correlation and logistical regression. The experimental variables were modeled against the subjective evaluation of an expert on the usability of the test samples.Statistical analysis proved that the dataset did not show any significant separation between “good” or “bad” test samples or a significant correlation between the usability of the test sample and the variables in the dataset. The methodology did not produce an objective material selection metric to determine the sound quality of an acoustic guitar’s soundboard. Future research should include a wider range of measured frequencies and the collection of time domain data.
Large-Scale Graphs Community Detection using Spark GraphFrames
Creators: name: Apostol, Elena-Simona
name: Cojocaru, Adrian-Cosmin
name: Truică, Ciprian-Octavian
Publisher: name: arXiv
Year: 2024
Subjects: subject: Social and Information Networks (cs.SI)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: With the emergence of social networks, online platforms dedicated to different use cases, and sensor networks, the emergence of large-scale graph community detection has become a steady field of research with real-world applications. Community detection algorithms have numerous practical applications, particularly due to their scalability with data size. Nonetheless, a notable drawback of community detection algorithms is their computational intensity~\cite{Apostol2014}, resulting in decreasing performance as data size increases. For this purpose, new frameworks that employ distributed systems such as Apache Hadoop and Apache Spark which can seamlessly handle large-scale graphs must be developed. In this paper, we propose a novel framework for community detection algorithms, i.e., K-Cliques, Louvain, and Fast Greedy, developed using Apache Spark GraphFrames. We test their performance and scalability on two real-world datasets. The experimental results prove the feasibility of developing graph mining algorithms using Apache Spark GraphFrames.
title: Physicochemical Feature Selection for Cathelicidin Antimicrobial Peptides
Creators: name: Veltri, Daniel Paul
Publisher: name: George Mason University
Year: 2013
Subjects: subject: Antimicrobial peptides
subject: AMPs
subject: Cathelicidins
subject: Support vector machine
subject: SVM
subject: Drug design

description: Due to recent attention on antimicrobial peptides (AMPs) as targets for antibacterial drug research, many machine learning methods are now turning their attention to AMP recognition. Approaches that rely on whole-peptide properties for recognition are challenged by the great sequence diversity among AMPs for effective feature construction. This thesis proposes a novel and complementary method for feature construction which relies on an extensive list of position-based amino acid physicochemical properties. These features are shown effective in the context of classification by support vector machine (SVM), both in comparison to related work in recognition of AMPs and in a novel study on the cathelicidin family. A detailed analysis and careful construction of a decoy dataset allows for the highlighting of antimicrobial activity-related features in cathelicidins. Special attention is also given to residue positions involved with enzymatic cleavage. The method presented in this thesis is a first step towards understanding what confers to cathelicidins their activity at the physicochemical level and may prove useful for future AMP design efforts.
title: The Man-Faced Bull of Gela
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2023
Subjects: subject: Numismatics
subject: Greek art
subject: Art history
subject: Ancient Sicilian art
subject: Ancient Mediterranean art
subject: Man-Faced Bull

description: The man-faced bull appears as a numismatic type in Magna Graecia and Sicily beginning in the late sixth century BCE. The man-faced bull coinage of various cities in Sicily served as a symbol of the political entity and cultural identity of a mixed demographic. This thesis examines man-faced bull coin-types issued in Gela between 491 and 400 BCE, delving into the identity and significance of the MFB motif. Through an examination of the intricate craftsmanship, materiality, and cultural interactions of this period, this thesis sheds light on the multifaceted identity of the MFB, specifically focusing on its role in Gela.
In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation
Creators: name: Matchett-Oates, Lennon
name: Braich, Shivraj
name: Spangenberg, German
name: Rochfort, Simone
name: Cogan, Noel
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Cannabis has been used worldwide for centuries for industrial, recreational and medicinal use, however, to date no successful attempts at editing genes involved in cannabinoid biosynthesis have been reported. This study proposes and develops an in silico best practices approach for the design and implementation of genome editing technologies in cannabis to target all genes involved in cannabinoid biosynthesis. A large dataset of reference genomes was accessed and mined to determine copy number variation and associated SNP variants for optimum target edit sites for genotype independent editing. Copy number variance and highly polymorphic gene sequences exist in the genome making genome editing using CRISPR, Zinc Fingers and TALENs technically difficult. Evaluation of allele or additional gene copies was determined through nucleotide and amino acid alignments with comparative sequence analysis performed. From determined gene copy number and presence of SNPs, multiple online CRISPR design tools were used to design sgRNA targeting every gene, accompanying allele and homologs throughout all involved pathways to create knockouts for further investigation. Universal sgRNA were designed for highly homologous sequences using MultiTargeter and visualised using Sequencher, creating unique sgRNA avoiding SNP and shared nucleotide locations targeting optimal edit sites. Using this framework, the approach has wider applications to all plant species regardless of ploidy number or highly homologous gene sequences. Using this framework, a best-practice approach to genome editing is possible in all plant species, including cannabis, delivering a comprehensive in silico evaluation of the cannabinoid pathway diversity from a large set of whole genome sequences. Identification of SNP variants across all genes could improve genome editing potentially leading to novel applications across multiple disciplines, including agriculture and medicine.
Volunteers’ Support of Carers of Rural People Living with Dementia to Use a Custom‐Built Application
Creators: name: Wilding, Clare
name: Davis, Hilary
name: Rasekaba, Tshepo
name: Hamiduzzaman, M
name: Royals, Kayla
name: Greenhill, J
name: O’Connell, Megan E.
name: Perkins, D
name: Bauer, Michael
name: Morgan, D
name: Blackberry, Irene
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: There is great potential for human‐centred technologies to enhance wellbeing for people living with dementia and their carers. The Virtual Dementia Friendly Rural Communities (Verily Connect) project aimed to increase access to information, support, and connection for carers of rural people living with dementia, via a co‐designed, integrated website/mobile application (app) and Zoom videoconferencing. Volunteers were recruited and trained to assist the carers to use the Verily Connect app and videoconferencing. The overall research design was a stepped wedge open cohort randomized cluster trial involving 12 rural communities, spanning three states of Australia, with three types of participants: carers of people living with dementia, volunteers, and health/aged services staff. Data collected from volunteers (n = 39) included eight interviews and five focus groups with volunteers, and 75 process memos written by research team members. The data were analyzed using a descriptive evaluation framework and building themes through open coding, inductive rea-soning, and code categorization. The volunteers reported that the Verily Connect app was easy to use and they felt they derived benefit from volunteering. The volunteers had less volunteering work than they desired due to low numbers of carer participants; they reported that older rural carers were partly reluctant to join the trial because they eschewed using online technologies, which was the reason for involving volunteers from each local community.
Supplementary document for Opto-thermoelectric trapping of Fluorescent Nanodiamonds on Plasmonic Nanostructures - 6403639.pdf
Creators: name: Shukla, Ashutosh
name: Tiwari, Sunny
name: Majumdar, Ayan
name: Saha, Kasturi
name: Kumar, G V Pavan
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Optical Physics not elsewhere classified

description: Supplementary information
Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR
Creators: name: Szeto, Christopher
name: Nguyen, Andrea
name: Lobos, CA
name: Chatzileontiadou, Dimitra
name: Jayasinghe, D
name: Grant, Emma
name: Riboldi-Tunnicliffe, A
name: Smith, C
name: Gras, Stephanie
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rapidly. While there are structures of some SARS-CoV-2 proteins in complex with antibodies, which helps us understand how the immune system is able to recognise this new virus; however, we lack data on how T cells are able to recognise this virus. T cells, especially the cytotoxic CD8+ T cells, are critical for viral recognition and clearance. Here we report the X-ray crystallography structure of a T cell receptor, shared among unrelated individuals (public TCR) in complex with a dominant spike-derived CD8+ T cell epitope (YLQ peptide). We show that YLQ activates a polyfunctional CD8+ T cell response in COVID-19 recovered patients. We detail the molecular basis for the shared TCR gene usage observed in HLA-A*02:01+ individuals, providing an understanding of TCR recognition towards a SARS-CoV-2 epitope. Interestingly, the YLQ peptide conformation did not change upon TCR binding, facilitating the high-affinity interaction observed.
XRISTIANLIK VA ISLOM, DINSHUNOSLIK NUQTAI NAZARIDAN QIYOS
Creators: name: Narziyev Shohruzjon Ma'ruf o'g'li  Muhammad al-Xorazmiy nomidagi Toshkent axborot texnologiyalari unversiteti  Samarqand filiali
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada xristianlik va islom dinlari dinshunoslik nuqtai nazaridan qiyosiy tahlil qilinadi. Har ikki dinning asosiy aqidaviy tamoyillari, ibodat tizimlari, diniy amaliyot va axloqiy qadriyatlari solishtirilib, ularning tarixiy shakllanishi va insoniyat taraqqiyotiga ta’siri yoritiladi. Maqolada dinshunoslikdagi tarixiy, empirik va fenomenologik yondashuvlar asosida tahlil yuritiladi. Xristianlik va islom o‘rtasidagi umumiylik va tafovutlar ilmiy asosda ko‘rsatilib, ularning bugungi davrdagi madaniy va ijtimoiy ahamiyati haqida xulosa chiqariladi.
Dance Is an Accessible Physical Activity for People with Parkinson's Disease
Creators: name: Emmanouilidis, Sara
name: Hackney, Madeleine E.
name: Slade, Susan
name: Heng, Hazel
name: Jazayeri, Dana
name: Morris, Meg
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Objective. To evaluate the outcomes of face-to-face, digital, and virtual modes of dancing for people living with Parkinson's disease (PD). Design. Systematic review informed by Cochrane and PRIMSA guidelines. Data Sources. Seven electronic databases were searched: AMED, Cochrane, PEDro, CINHAL, PsycINFO, EMBASE, and MEDLINE. Methods. Eligible studies were randomised controlled trials (RCT) and other trials with quantitative data. The PEDro scale evaluated risk of bias for RCTs. Joanna Briggs Institute instruments were used to critically appraise non-RCTs. The primary outcome was the feasibility of dance interventions, and the secondary outcomes included gait, balance, quality of life, and disability. Results. The search yielded 8,327 articles after duplicates were removed and 38 met the inclusion criteria. Seven were at high risk of bias, 20 had moderate risk of bias, and 11 had low risk of bias. There was moderately strong evidence that dance therapy was beneficial for balance, gait, quality of life, and disability. There was good adherence to digital delivery of dance interventions and, for people with PD, online dance was easy to access. Conclusion. Dancing is an accessible form of exercise that can benefit mobility and quality of life in people with PD. The COVID-19 pandemic and this review have drawn attention to the benefits of access to digital modes of physical activity for people living with chronic neurological conditions.
Quantifying the sources of variation in eosinophilia among Scottish blackface lambs with mixed, predominantly Teladorsagia circumcincta nematode infection
Creators: name: Jenvey, Caitlin
name: Almasi, Fazel
name: Halliwell, Emma Una
name: Li, Xia
name: Piedrafita, D
name: Preston, S
name: Stear, Michael
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3009
subject: Veterinary sciences
subject: FOS: Veterinary sciences

description: Eosinophils play a key role in defence against gastrointestinal nematodes. There is considerable variation among animals in the intensity of eosinophilia following nematode infection. However, the statistical distribution of eosinophils among animals has still to be determined. A better description of the variation among animals could provide biological insight and determine the most appropriate way to analyse the effect of eosinophils. We estimated blood eosinophil numbers in a flock of Scottish Blackface sheep that were naturally exposed to mixed, predominantly Teladorsagia circumcincta infection. Three of the four eosinophil counts were better described by a gamma distribution than by a lognormal distribution. The scale and shape parameters of the gamma distribution varied over time. Eosinophil counts differed among animals kept on separate fields before weaning and between singletons and twins but were not significantly different between years and genders. Eosinophil counts also differed among offspring from different sires and dams. The parameters of the gamma distribution were used to enable a power analysis. Large numbers of animals were required to reliably detect even large differences between two groups. These results indicate that methods appropriate for gamma distributions, such as generalized linear mixed models, will provide more reliable inferences than traditional methods of analysis and experimental design.
title: The Enemy of My Enemy: Rebel Group Strategies at the Onset of Civil Conflicts
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Civil conflict
subject: Civil war
subject: Mixed methods
subject: Nationalism
subject: Post-Soviet
subject: Rebel group
subject: Political science
subject: FOS: Political science
subject: International relations
subject: Slavic studies

description: This dissertation seeks to explain the why some rebel groups target the state while others target fellow armed groups. Much of the literature focuses on features of the state to explain intrastate violence, but I propose to turn the spotlight onto groups themselves, specifically their organizational control structure and relative material capabilities. At the onset of a civil conflict, groups can 1) target the state, 2) target other groups, 3) engage in mixed targeting, or 4) engage in reactive/no targeting. I argue that organizational structure informs which groups are likely to view as their primary threat, while relative capabilities provide groups with agency in combat: those with high/symmetric capabilities have focus, while those with low capabilities are more opportunistic. Through an examination of five civil conflicts in post-Soviet and post-Communist countries and statistical modeling with a novel dataset, I demonstrate that these two variables in conjunction with one another map onto the varied configurations of group targeting.
Quantifying the sources of variation in eosinophilia among Scottish blackface lambs with mixed, predominantly Teladorsagia circumcincta nematode infection
Creators: name: Jenvey, Caitlin
name: Almasi, Fazel
name: Halliwell, EU
name: Li, Xia
name: Piedrafita, D
name: Preston, S
name: Stear, Michael
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Eosinophils play a key role in defence against gastrointestinal nematodes. There is considerable variation among animals in the intensity of eosinophilia following nematode infection. However, the statistical distribution of eosinophils among animals has still to be determined. A better description of the variation among animals could provide biological insight and determine the most appropriate way to analyse the effect of eosinophils. We estimated blood eosinophil numbers in a flock of Scottish Blackface sheep that were naturally exposed to mixed, predominantly Teladorsagia circumcincta infection. Three of the four eosinophil counts were better described by a gamma distribution than by a lognormal distribution. The scale and shape parameters of the gamma distribution varied over time. Eosinophil counts differed among animals kept on separate fields before weaning and between singletons and twins but were not significantly different between years and genders. Eosinophil counts also differed among offspring from different sires and dams. The parameters of the gamma distribution were used to enable a power analysis. Large numbers of animals were required to reliably detect even large differences between two groups. These results indicate that methods appropriate for gamma distributions, such as generalized linear mixed models, will provide more reliable inferences than traditional methods of analysis and experimental design.
"Flipped" vs traditional anatomy lectures to deliver content using anatomical principles, quantitative and qualitative student outcomes
Creators: name: Green, Rodney
name: Al-Aubaidy, Hayder
name: Whitburn, Laura
name: Hughes, Diane
name: Silvester, Alvington
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3208
subject: Medical physiology

description: No description supplied
Managing Depression in Adolescents: A Case Study Focusing on the Assessment and Treatment of Depression in a Teenage Client
Creators: name: Abidogun, Moruf Adebayo
name: Adedayo Daodu, Morufu
name: Mumuni, Malik Adekunle
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 520303
subject: Counselling psychology
classificationCode: 420313
subject: Mental health services

description: This case study delves into the critical aspects of assessing and treating depression in adolescent, shedding light on the complexities of mental health interventions in this category. By closely examining a specific teenage client's journey, the study explores the nuanced challenges faced by both the individual and the therapist. Through a comprehensive assessment process, including psychological, social, and environmental factors, effective treatment strategies were identified and implemented. The narrative underscores the importance of tailored interventions, emphasizing the need for a holistic approach that considers the unique developmental and contextual factors impacting adolescents. The findings contribute valuable insights to the field of mental health, offering practitioners, educators, and caregivers a deeper understanding of evidence-based practices to address depression in teenagers.
title: Ruin Theory
Creators: name: Fehr, Ashley
Publisher: name: George Mason University
Year: 2016
Subjects: subject: Ruin Theory
subject: Compound Poisson
subject: Adjustment coefficient
subject: Monte Carlo

description: Classical ruin theory was developed by Lundberg in 1907 and refined by Cramer in 1930. This theory describes the evolution of the surplus of an insurance company over time. It assumes that an insurance company begins with an initial surplus and then receives premiums continuously at a constant rate. It also assumes that claims of random and independent size are paid at random and independent times. Ruin occurs when the surplus becomes negative meaning that the average inflow of money (premiums) is smaller than the average outflow of money (claims). Cramer expanded on this theory to show that probability of ruin decays exponentially fast as the initial surplus grows larger. This paper will synthesize some of the key results from Ruin Theory. These results will not be proven via formula but will be conclusively demonstrated using simulation.
Audiologists’ perspective on the treatment of ear‐related ear, nose, and throat conditions in rural Victoria
Creators: name: O'Neill, Susan
name: Van-Vuuren, Julia
name: Begg, Stephen
name: MacDonald, Jane
name: MacDermott, Sean
name: Spelten, Evelien
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems

description: No description supplied
Relationships between Physical Activity, Work Ability, Absenteeism and Presenteeism in Australian and New Zealand Adults during COVID-19
Creators: name: Hunter, Jayden
name: Cripps, Ashley
name: Meiring, Rebecca
name: Suppiah, Haresh
name: Vicendese, Donato
name: Kingsley, Michael
name: Gordon, Brett
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: No description supplied
BIOLOGIYANI FIZIKA BILAN BOG'LAB O'QITISHDA KONFERENSIYALAR TASHKIL ETISH
Creators: name: G'aniyeva, Guliruxsor
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada fanlar taraqqiyotidagi ikki obyektiv xususiyat – differensiatsiya (tarmoqlanish) va integratsiya (qo‘shilish, birlashish), pirovard natijada, olamning yaxlit, umumiy ilmiy manzarasi yaralishi, biologiya va fizika fanlaridan konferensiyalar tashkil etishning ahamiyati haqida ma’lumotlar berilgan.
title: Creations of Domestic Tastes: Portières in the American Interior, 1876-1910
Creators: name: Skinner, Kristen
Publisher: name: George Mason University
Year: 2016
Subjects: subject: Portières
subject: Nineteenth century
subject: Interiors
subject: United States
subject: Publications

description: This thesis examines portière designs found in journal and newspaper articles aimed at American middle-class domestic women during the height of the Aesthetic Movement to the end of its major influence in the United States. These designs illustrate a popular artistic style influenced by Aestheticism and high-style works and taste literature, and a distinction is needed between such popular artistic style and high-style artistic design in contemporary scholarship.
MetaDragonBoat: Exploring Paddling Techniques of Virtual Dragon Boating in a Metaverse Campus
Creators: name: He, Wei
name: Li, Xiang
name: Xu, Shengtian
name: Chen, Yuzheng
name: Sio, Chan-In
name: Kan, Ge Lin
name: Lee, Lik-Hang
Publisher: name: arXiv
Year: 2024
Subjects: subject: Multimedia (cs.MM)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: The preservation of cultural heritage, as mandated by the United Nations Sustainable Development Goals (SDGs), is integral to sustainable urban development. This paper focuses on the Dragon Boat Festival, a prominent event in Chinese cultural heritage, and proposes leveraging Virtual Reality (VR), to enhance its preservation and accessibility. Traditionally, participation in the festival's dragon boat races was limited to elite athletes, excluding broader demographics. Our proposed solution, named MetaDragonBoat, enables virtual participation in dragon boat racing, offering immersive experiences that replicate physical exertion through a cultural journey. Thus, we build a digital twin of a university campus located in a region with a rich dragon boat racing tradition. Coupled with three paddling techniques that are enabled by either commercial controllers or physical paddle controllers with haptic feedback, diversified users can engage in realistic rowing experiences. Our results demonstrate that by integrating resistance into the paddle controls, users could simulate the physical effort of dragon boat racing, promoting a deeper understanding and appreciation of this cultural heritage.
description: 10 pages, accepted at ACM MM 2024