cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EVALUATION OF ARTHROCENTESIS WITH HYALURONIC ACID INJECTIONS FOR MANAGEMENT OF TEMPOROMANDIBULAR DISORDERS
Creators: name: GOKER, FUNDA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Objectives: Although, arthrocentesis is an accepted safe treatment modality used for the management of TMD patients with pain, the benefit of hyaluronic acid (HA) injections remains uncertain. The aim of this study was to investigate whether intra-articular injections of hyaluronic acid as an adjunct therapy with arthrocentesis can be more effective than other medications for the improvement of symptoms associated with temporomandibular disorders. Materials and methods: For this purpose, an electronic search of Medline, Scopus and Cochrane databases was performed up to September 2020. No language, and publication date limitation was set. The following search terms were used: ?arthrocentesis?, ?hyaluronic acid?, ?intra-articular injections?, ?viscosupplementation?, with ?temporomandibular disorders?. Inclusion criteria was prospective or retrospective studies, case reports, and randomized clinical trials that reported the application of HA injections compared to other intra-articular drugs for the treatment of temporomandibular disorders. Exclusion criteria included systemic reviews, animal studies. Additionally, a retrospective clinical study was performed on 12 TMD cases for evaluation of changes before and after arthrocentesis with hyaluronic acid (HA) injections in quality of life (QoL) of these patients. Results: In the systemic review, the initial screening included 1327 articles. After a more detailed evaluation of the titles, abstracts, and full texts; a total of 29 studies were selected (26 randomized studies, 2 controlled clinical trials, 1 retrospective report). In the clinical study 12 patients were included. According to the results, intra-articular injections of HA and other medications together with arthrocentesis seemed to be beneficial for improvement of functional symptoms of TMD and pain. The case series also supported support the efficacy of HA injections with a significant improvement of QoL of these patients. However, after the evaluation of the reports in literature, it was impossible to identify an optimum drug or a protocol in improving the pain and/or functional symptoms of temporomandibular problems due to diversity of treatment modalities and conflicting results. Conclusion: As a conclusion, there was no consensus in the studies that HA injections showed better results in comparison with other treatment modalities. According to the results of this systematic review and clinical study HA injections with/without arthrocentesis seems to be beneficial in terms of clinical symptoms and QoL of the patients.
Frozen State and Spin Liquid Physics in Na4Ir3O8: an NMR study
Creators: name: Shockley, A. C.
name: Bert, F.
name: Orain, J-C
name: Okamoto, Y.
name: Mendels, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Na4Ir3O8 is a unique case of a hyperkagome 3D corner sharing triangular lattice which can be decorated with quantum spins. It has spurred a lot of theoretical interest as a spin liquid candidate. We present a comprehensive set of NMR data taken on both the 23Na and 17O sites. We show that disordered magnetic freezing of all Ir sites sets in below Tf $\sim$ 7 K, well below J = 300 K, with a drastic slowing down of fluctuations to a static state revealed by our T1 measurements. Above typically 2Tf, physical properties are relevant to the spin liquid state induce by this exotic geometry. While the shift data shows that the susceptibility levels off below 80 K, 1/T1 has little variation from 300K to 2Tf. We discuss the implication of our results in the context of published experimental and theoretical work.
description: 5 pages, 4 figures
Supplementary Figure 4 from α-Amylase immobilization on amidoximated acrylic microfibres activated by cyanuric chloride.
Creators: name: Yaaser Q. Almulaiky
name: Aqlan, Faisal M.
name: Musab Aldhahri
name: Baeshen, Mohammed
name: Khan, Tariq Jamal
name: Khan, Khalid A.
name: Afifi, Mohamed
name: AL-Farga, Ammar
name: Mohiuddin Khan Warsi
name: Alkaled, Mohammed
name: Alayafi, Aisha A. M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Reuse of immobilized α-amylase
Inhibition of Werner Syndrome Helicase Activity by Benzo[ c ]phenanthrene Diol Epoxide dA Adducts in DNA Is Both Strand-and Stereoisomer-dependent
Creators: name: Kroth, Heiko
name: Jerina, Donald M.
name: Sayer, Jane M.
name: Brosh Jr., Robert M.
name: Matson, Steven W.
name: Driscoll, Henry C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Helicases are among the first enzymes to encounter DNA damage during DNA processing within the cell and thus are likely to be targets for the adverse effects of DNA lesions induced by environmental chemicals. Here we examined the effect of cis- and trans-opened 3,4-diol 1,2-epoxide (DE) DNA adducts of benzo[c]phenanthrene (BcPh) at N6 of adenine on helicase activity. These adducts are derived from the highly tumorigenic (-)-(1R,2S,3S,4R)-DE as well as its less carcinogenic (+)-(1S,2R,3R,4S)-DE enantiomer in both of which the benzylic 4-hydroxyl group and epoxide oxygen are trans. The hydrocarbon portions of these adducts intercalate into DNA on the 3' or the 5' side of the adducted deoxyadenosine for the 1S- and 1R-adducts, respectively. These adducts inhibited the human Werner (WRN) syndrome helicase activity in a strand-specific and stereospecific manner. In the strand along which WRN translocates, cis-opened adducts were significantly more effective inhibitors than trans-opened isomers, indicating that WRN unwinding is sensitive to adduct stereochemistry. WRN helicase activity was also inhibited but to a lesser extent by cis-opened BcPh DE adducts in the displaced strand independent of their direction of intercalation, whereas inhibition by the trans-opened stereoisomers in the displaced strand depended on their orientation, such that only adducts oriented toward the advancing helicase inhibited WRN activity. A BcPh DE adduct positioned in the helicase-translocating strand did not sequester WRN, nor affect the rate of ATP hydrolysis relative to an unadducted control. Although the Bloom (BLM) syndrome helicase was also inhibited by a cis-opened adduct in a strand-specific manner, this helicase was not as severely affected as WRN. Because BcPh DEs form substantial amounts of deoxyadenosine adducts at dA, their adverse effects on helicases could contribute to genetic damage and cell transformation induced by these DEs. Thus, the unwinding activity of RecQ helicases is sensitive to the strand, orientation, and stereochemistry of intercalated polycyclic aromatic hydrocarbon adducts.
Table S4 from Sex mosaics in the honeybee: how haplodiploidy makes possible the evolution of novel forms of reproduction in social Hymenoptera
Creators: name: Aamidor, Sarah E.
name: Yagound, Boris
name: Ronai, Isobel
name: Oldroyd, Benjamin P.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology

description: mtDNA Alignment
(1720) Sarah Fok
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dilepton production and reaction dynamics in heavy-ion collisions at SIS energies from coarse-grained transport simulations
Creators: name: Endres, Stephan
name: van Hees, Hendrik
name: Weil, Janus
name: Bleicher, Marcus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Dilepton invariant-mass spectra for heavy-ion collisions at SIS 18 and BEVALAC energies are calculated using a coarse-grained time evolution from the Ultra-relativistic Quantum Molecular Dynamics (UrQMD) model. The coarse-graining of the microscopic simulations enables to calculate thermal dilepton emission rates by application of in-medium spectral functions from equilibrium quantum-field theoretical calculations. The results show that extremely high baryon chemical potentials dominate the evolution of the created hot and dense fireball. Consequently, a significant modification of the $ρ$ spectral shape becomes visible in the dilepton invariant-mass spectrum, resulting in an enhancement in the low-mass region $M_{ee} = 200$ to 600 MeV/$c^{2}$. This enhancement, mainly caused by baryonic effects on the $ρ$ spectral shape, can fully describe the experimentally observed excess above the hadronic cocktail contributions in Ar+KCl ($E_{\mathrm{lab}}=1.76$ $A$GeV) reactions as measured by the HADES collaboration and also gives a good explanation of the older DLS Ca+Ca ($E_{\mathrm{lab}}=1.04$ $A$GeV) data. For the larger Au+Au ($E_{\mathrm{lab}}=1.23$ $A$GeV) system, we predict an even stronger excess from our calculations. A systematic comparison of the results for different system sizes from C+C to Au+Au shows that the thermal dilepton yield increases stronger ($\propto A^{4/3}$) than the hadronic background contributions, which scale with $A$, due to its sensitivity on the time evolution of the reaction. We stress that the findings of the present work are consistent with our previous coarse-graining results for the NA60 measurements at top SPS energy. We argue that it is possible to describe the dilepton results from SIS 18 up to SPS energies by considering the modifications of the $ρ$ spectral function inside a hot and dense medium within the same model.
description: 15 pages, 9 figures
Interaction of the Tyrosine Kinase Pyk2 with the N -Methyl-d-aspartate Receptor Complex via the Src Homology 3 Domains of PSD-95 and SAP102
Creators: name: Lim, Indra A.
name: Weinberg, Richard J.
name: Seabold, Gail K.
name: Burette, Alain
name: Hell, Johannes W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The protein-tyrosine kinase Pyk2/CAKbeta/CADTK is a key activator of Src in many cells. At hippocampal synapses, induction of long term potentiation requires the Pyk2/Src signaling pathway, which up-regulates the activity of N-methyl-d-aspartate-type glutamate receptors. Because localization of protein kinases close to their substrates is crucial for effective phosphorylation, we investigated how Pyk2 might be recruited to the N-methyl-d-aspartate receptor complex. This interaction is mediated by PSD-95 and its homolog SAP102. Both proteins colocalize with Pyk2 at postsynaptic dendritic spines in the cerebral cortex. The proline-rich regions in the C-terminal half of Pyk2 bind to the SH3 domain of PSD-95 and SAP102. The SH3 and guanylate kinase homology (GK) domain of PSD-95 and SAP102 interact intramolecularly, but the physiological significance of this interaction has been unclear. We show that Pyk2 effectively binds to the Src homology 3 (SH3) domain of SAP102 only when the GK domain is removed from the SH3 domain. Characterization of PSD-95 and SAP102 as adaptor proteins for Pyk2 fills a critical gap in the understanding of the spatial organization of the Pyk2-Src signaling pathway at the postsynaptic site and reveals a physiological function of the intramolecular SH3-GK domain interaction in SAP102.
INDEPENDENT HYPOTHALAMIC CIRCUITS FOR SOCIAL AND PREDATOR FEAR
Creators: name: SILVA, BIANCA AMBROGINA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Fear is a distressing negative sensation induced by a perceived threat. This emotion is necessary for the survival of the individual, since it guarantees appropriate responses to life challenging threats. In the last decades research on the neural mechanisms underling such emotion both in humans and in animal models have been mostly focused on the amygdala. In particular fear models in rodents typically rely on foot shock based paradigms. However, innate and learned fear elicited by other stimuli such as predators or aggressive members of the same species has been shown to be regulated by other circuits where the triggering, coordination and the expression of fear seem to be centered in the hypothalamus and periaqueductal grey. Nevertheless very little is known about the function and physiology of these structures in fear processing. To study the function of the medial hypothalamic fear circuit, we developed a novel behavioral paradigm to measure innate and conditioned fear responses to social and predator threats in mice. We subsequently created tools to selectively inhibit specific hypothalamic nuclei during the fear and we observed the inhibition of the ventromedial hypothalamus, a nucleus previously studied for its function in feeding, sex and aggression, specifically impaired social and predator fear but not foot shock fear. Moreover we demonstrated that different portions of this nucleus account for fear to different threats with the dorsomedial portion, previously implicated in feeding function, processing predator fear, and the ventrolateral portion, previously implicated in sex and aggression, processing social fear. Our results demonstrate that the hypothalamus plays a crucial role in fear processing even if it is not recruited during foot shock exposure, suggesting that it might be a good target for the treatment of fear related disorders like panic or phobias and we are now trying to identify possible drugs specifically acting in this area. On the other hand, we showed that specific hypothalamic subnuclei are recruited selectively during social or predator fear, corroborating the hypothesis that different types of fear are processed by separate brain circuits. Such evidence opens the possibility of targeted therapy of pathological fear in humans. Interestingly these same hypothalamic structures are fundamental regulators of non-fear motivated behaviors that are essential for survival such as feeding behavior, aggression and sex and we are now investigating how the same nuclei can orchestrate multiple functions.
Microscopic Parameters from High-Resolution Specific Heat Measurements on Overdoped BaFe$_{2}$(As$_{1-x}$P$_{x}$)$_{2}$ Single Crystals
Creators: name: Diao, Z.
name: Campanini, D.
name: Fang, L.
name: Kwok, W. K.
name: Welp, U.
name: Rydh, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We investigate the electronic specific heat of overdoped BaFe$_{2}$(As$_{1-x}$P$_{x}$)$_{2}$ single crystals in the superconducting state using high-resolution nanocalorimetry. From the measurements, we extract the doping dependence of the condensation energy, superconducting gap $Δ$, and related microscopic parameters. We find that the anomalous scaling of the specific heat jump $ΔC \propto T_{\mathrm{c}}^3$, found in many iron-based superconductors, in this system originates from a $T_\mathrm{c}$-dependent ratio $Δ/k_\mathrm{B}T_\mathrm{c}$ in combination with a doping-dependent density of states $N(\varepsilon_\mathrm{F})$. A clear enhancement is seen in the effective mass $m^{*}$ as the composition approaches the value that has been associated with a quantum critical point at optimum doping. However, a simultaneous increase in the superconducting carrier concentration $n_\mathrm{s}$ maintains the superfluid density, yielding an apparent penetration depth $λ$ that decreases with increasing $T_\mathrm{c}$ without sharp divergence at the quantum critical point. Uemura scaling indicates that $T_\mathrm{c}$ is governed by the Fermi temperature $T_\mathrm{F}$ for this multi-band system.
description: 5 pages, 3 figures
MALNUTRITION AND PHYSICAL PERFORMANCE IN NURSING HOME RESIDENTS: RESULTS FROM THE INCUR STUDY
Creators: name: DAMANTI, SARAH
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Objectives: to investigate the association between malnutrition and physical performance in nursing home residents. Design: cross sectional study. Setting and Participants: a total of 499 older people (73.1% women) enrolled in the Incidence of pNeumonia and related ConseqUences in nursing home Residents (INCUR) cohort study. Methods: the nutritional status was defined using the Mini Nutritional Assessment?Short Form (MNA-SF), whereas the physical performance was measured with the Short Physical Performance Battery (SPPB). Unadjusted and adjusted (for age, sex, education, Abbreviated Mental Test score and Charlson Comorbidy Index) linear regression analyses were used to assess the association between MNA-SF and SPPB (primary outcome). The MNA-SF items which seemed most strongly related to the SPPB (and its subtasks) were also explored. Finally, we explored the association of the MNA-SF with each subtest of the SPPB. Results: the mean age of the sample was 85.80 (standard deviation, SD 7.20). The mean SPPB score was 3.05 (SD 2.65) and the mean MNA-SF score 10.35 (SD 2.22). Higher scores of MNA-SF were associated with better physical performance. Food intake deficiency, mobility impairment, and recent psychological stress or acute disease were the items of the MNA-SF most strongly associated with the SPPB, even after adjustment for potential confounders. Among the three subtests of the SPPB, the MNA-SF showed the strongest and most consistent association with the gait speed. Conclusions and Implications: among nursing home residents, the MNA-SF and three of its sub-items (food intake deficiency, mobility impairment, and recent psychological stress) are significantly correlated with physical performance, independently of potential confounders. In particular, the association was evident for the gait speed subtask of the SPPB.
Using geometry to manipulate long-range correlation of light inside disordered media
Creators: name: Sarma, Raktim
name: Yamilov, Alexey
name: Neupane, Pauf
name: Cao, Hui
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate experimentally that long-range intensity correlation for light propagating inside random photonic waveguides can be modified by changing the shape of the waveguide. The functional form of spatial correlation is no longer universal in the regime of diffusive transport and becomes shape-dependent due to the non-local nature of wave propagation. The spatial dependence of the correlation may be asymmetric for light incident from opposite ends of the waveguide. This work opens the door to control non-local effects in mesoscopic transport of waves by manipulating the geometry of random systems.
description: 5 pages, 4 figures
THE LONG PENTRAXIN 3 PLAYS A KEY ROLE IN THE IMMUNOMODULATION OF DIET-INDUCED OBESITY
Creators: name: MOREGOLA, ANNALISA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: The long pentraxin 3 plays a key role in the immunomodulation of diet-induced obesity AIM: Obesity is characterized by a state of chronic low-grade inflammation. PTX3 is the prototype of long pentraxins, it is an essential component of the humoral arm of innate immunity and is involved in many inflammatory processes. There are several conflicting data about the role of PTX3 in obesity. Aim of this project was to clarify whether PTX3 behaves as a bystander or actively participates to obesity-related inflammation. METHODS: PTX3 KO and WT littermates were fed a high fat diet (HFD; 45% Kcal from fat) or a standard fata diet (SFD;10% Kcal from fat) for 20 weeks. Body weight was measured weekly; fat distribution (magnetic resonance for imaging, MRI) and glycemia (glucose-GTT and insulin-ITT tolerance tests) was checked at 10 and 20 weeks. Immunophenotyping and gene expression, in particular of the adipose tissue, was performed at 20 weeks. Ectopic fat deposition in h1/h1 and h2/h2 individuals was determined by DEXA. RESULTS: PTX3 KO mice on HFD exhibit a decreased weight gain compared to WT (AUC weight gain WT=190.8�17.45, KO=134.8�10.09), coupled to a decreased accumulation of visceral (VAT) and subcutaneous (SCAT) fat both at 10 (p<0.05) and 20 weeks (p<0.01) of diet measured by MRI and confirmed weighing the tissues after the sacrifice (VAT% WT=7.609�0.6776, KO=4.390�0.8235; SCAT% WT=5.953�0.9682, KO=3.144�0.6129, p<0.05). Basal glycemia and the results of the glucose and insulin tolerance test were superimposable. PTX3 deficiency results in the reduction of monocytes markers and pro-inflammatory cytokines gene expression in VAT (MCP-1, IL-6, p<0.05) which is associated to a reduced infiltration of monocytes and macrophages in the tissue as assessed by cell sorting. Of note vascularization was enhanced (increased gene expression of Cd31 and Vegfa in VAT, p<0.05) in VAT from PTX3 KO mice. Sorted VAT macrophages showed enhanced expression of molecules associated with M2-polarization (Arg1, Ym-1, p<0.01). In humans, carriers of the h2/h2 haplotype for PTX3, characterized by lower PTX3 plasma levels compared to h1/h1 carriers, presented with lower BMI and lower abdominal obesity compare to h1/h1 carriers (android fat% h2/h2=45.34�10.32, h1/h1=47.17�9.23, p<0.05). CONCLUSIONS: Our results demonstrate that PTX3 might contribute to the development of obesity by limiting adipose tissue vascularization and promoting macrophage infiltration.
On the generation of triaxiality in the collapse of cold spherical self-gravitating systems
Creators: name: Labini, Francesco Sylos
name: Benhaiem, David
name: Joyce, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Initially cold and spherically symmetric self-gravitating systems may give rise to a virial equilibrium state which is far from spherically symmetric, and typically triaxial. We focus here on how the degree of symmetry breaking in the final state depends on the initial density profile. We note that the most asymmetric structures result when, during the collapse phase, there is a strong injection of energy preferentially into the particles which are localized initially in the outer shells. These particles are still collapsing when the others, initially located in the inner part, are already re-expanding; the motion of particles in a time varying potential allow them to gain kinetic energy --- in some cases enough to be ejected from the system. We show that this mechanism of energy gain amplifies the initial small deviations from perfect spherical symmetry due to finite $N$ fluctuations. This amplification is more efficient when the initial density profile depends on radius, because particles have a greater spread of fall times compared to a uniform density profile, for which very close to symmetric final states are obtained}. These effects lead to a distinctive correlation of the orientation of the final structure with the distribution of ejected mass, and also with the initial (very small) angular fluctuations.
description: 8 pages, 8 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal
(1715) Samuel Pope
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Figure 4 from α-Amylase immobilization on amidoximated acrylic microfibres activated by cyanuric chloride
Creators: name: Yaaser Q. Almulaiky
name: Aqlan, Faisal M.
name: Musab Aldhahri
name: Baeshen, Mohammed
name: Khan, Tariq Jamal
name: Khan, Khalid A.
name: Afifi, Mohamed
name: AL-Farga, Ammar
name: Mohiuddin Khan Warsi
name: Alkaled, Mohammed
name: Alayafi, Aisha A. M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Reuse of immobilized α-amylase
(1716) Ann [Pope]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Figure 2 from α-Amylase immobilization on amidoximated acrylic microfibres activated by cyanuric chloride.
Creators: name: Yaaser Q. Almulaiky
name: Aqlan, Faisal M.
name: Musab Aldhahri
name: Baeshen, Mohammed
name: Khan, Tariq Jamal
name: Khan, Khalid A.
name: Afifi, Mohamed
name: AL-Farga, Ammar
name: Mohiuddin Khan Warsi
name: Alkaled, Mohammed
name: Alayafi, Aisha A. M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: FTIR
Biomolecules in Open Force Field: Goals made possible by new NIH funding
Creators: name: Shirts, Michael R.
Publisher: name: Zenodo
Year: 2020
Subjects: Open Force Field Initiative
force fields
infrastructure
biopolymers
Bayesian inference
surrogate modeling

description: This presentation is a part of the Open Force Field Virtual Meeting 2020. Abstract: An overview of the aims for force field development proposed in the NIH grant awarded to the Open Force Field Initiative.
Involvement of Phospholipase D2 in Lysophosphatidate-induced Transactivation of Platelet-derived Growth Factor Receptor-β in Human Bronchial Epithelial Cells
Creators: name: Brindley, David N.
name: Zhao, Yutong
name: Cummings, Rhett
name: Kazlauskas, Andrius
name: Morris, Andrew
name: Wang, Lixin
name: Georas, Steve
name: Sham, James K.S.
name: Natarajan, Viswanathan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Lysophosphatidate (LPA) mediates multiple cellular responses via heterotrimeric G protein coupled LPA-1, LPA-2, and LPA-3 receptors. Many G protein-coupled receptors stimulate ERK following tyrosine phosphorylation of growth factor receptors; however, the mechanism(s) of transactivation of receptor tyrosine kinases are not well defined. Here, we provide evidence for the involvement of phospholipase D (PLD) in LPA-mediated transactivation of platelet-derived growth factor receptor-beta (PDGF-R beta). In primary cultures of human bronchial epithelial cells (HBEpCs), LPA stimulated tyrosine phosphorylation of PDGF-R beta and threonine/tyrosine phosphorylation of ERK1/2. The LPA-mediated activation of ERK and tyrosine phosphorylation of PDGF-R beta was attenuated by tyrphostin AG 1296, an inhibitor of PDGF-R kinase, suggesting transactivation of PDGF-R by LPA. Furthermore, LPA-, but not PDGF beta-chain homodimer-induced tyrosine phosphorylation of PDGF-R beta was partially blocked by pertussis toxin, indicating coupling of LPA-R(s) to Gi. Exposure of HBEpCs to LPA activated PLD. Butan-1-ol, which acts as an acceptor of phosphatidate generated by the PLD pathway, blocked LPA-mediated transactivation of PDGF-R beta. This effect was not seen with butan-3-ol, suggesting PLD involvement. The role of PLD1 and PLD2 in the PDGF-R beta transactivation by LPA was investigated by infection of cells with adenoviral constructs of wild type and catalytically inactive mutants of PLD. LPA activated both PLD1 and PLD2 in HBEpCs; however, infection of cells with cDNA for wild type PLD2, but not PLD1, increased the tyrosine phosphorylation of PDGF-R beta in response to LPA. Also, the LPA-mediated tyrosine phosphorylation of PDGF-R beta was attenuated by the catalytically inactive mutant mPLD2-K758R. Infection of HBEpCs with adenoviral constructs of wild type hPLD1, mPLD2, and the inactive mutants of hPLD1 and mPLD2 resulted in association of PLD2 wild type and inactive mutant proteins with the PDGF-R beta compared with PLD1. These results show for the first time that transactivation of PDGF-R beta by LPA in HBEpCs is regulated by PLD2.
Spectral dimension and Bohr's formula for Schrodinger operators on unbounded fractal spaces
Creators: name: Chen, Joe P.
name: Molchanov, Stanislav
name: Teplyaev, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: Metric Geometry (math.MG)
subject: Probability (math.PR)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 81Q35, 81Q10, 60J25, 60J35, 28A80, 30D30, 31E05, 35P20, 47A75

description: We establish an asymptotic formulas for the eigenvalue counting function of the Schrödinger operator $-Δ+V$ for some unbounded potentials $V$ on several types of unbounded fractal spaces. We give sufficient conditions for Bohr's formula to hold on metric measure spaces which admit a cellular decomposition, and then verify these conditions for fractafolds and fractal fields based on nested fractals. In particular, we partially answer a question of Fan, Khandker, and Strichartz regarding the spectral asymptotics of the harmonic oscillator potential on the infinite blow-up of a Sierpinski gasket.
description: v2: 28 pages, 6 figures. referee comments included, typos corrected
INTELLECTUAL PROPERTY RIGHTS FOR LIFE FORMS: A LEGAL DISCOURSE TO INDIAN LEGAL FRAMEWORK
Creators: name: Wasiq, Mohammad Rasikh
name: SADAT NASSERI, SAYED ARSALAN
Publisher: name: figshare
Year: 2023
Subjects: Intellectual property law
Property law (excl. intellectual property law)

description: This article attempts to define and analyses the various legal regimes governing intellectual property rights in the protection of life forms, the patent on life forms, and plant varieties and sets forth regulatory options for national governments to protect plant varieties while achieving other public policy objectives relating to plant genetic resources. A patent can be understood as an IPR relating to inventions and is the grant of exclusive right, for a limited period, provided by the Government to the patentee, in exchange for full disclosure of his invention, for excluding others, from making, using, selling, importing the patented product or process producing that product for those purposes. It also identifies the international institutions and intergovernmental organizations that regulate intellectual property rights in plant varieties and plant genetic resources generally and describes the core obligations outlined in international intellectual property agreements.
Supplementary Figure 1 from α-Amylase immobilization on amidoximated acrylic microfibres activated by cyanuric chloride.
Creators: name: Yaaser Q. Almulaiky
name: Aqlan, Faisal M.
name: Musab Aldhahri
name: Baeshen, Mohammed
name: Khan, Tariq Jamal
name: Khan, Khalid A.
name: Afifi, Mohamed
name: AL-Farga, Ammar
name: Mohiuddin Khan Warsi
name: Alkaled, Mohammed
name: Alayafi, Aisha A. M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Effect of immobilization time
L’argumentation abstraite et la probabilité imprécise pour l'ingénierie forensique
Creators: name: Taillandier, Franck
name: Baudrit, Cédric
name: Carvajal, Claudio
name: Beullac, Bruno
Publisher: name: Academic Journal of Civil Engineering
Year: 2021

description: Les ouvrages de génie civil sont régulièrement confrontés à des défaillances qui peuvent avoir des conséquences catastrophiques. Il est important de pouvoir identifier l'origine et la séquence des facteurs qui ont mené à la défaillance. Cette analyse des défaillances par des experts, appelée ingénierie forensique, conduit généralement à la rédaction d'un rapport d'expertise. Cet article propose une nouvelle approche méthodologique pour formaliser les avis des experts en ingénierie forensique. Elle consiste à combiner l'argumentation abstraite avec la théorie des probabilités imprécises pour prendre en compte les incertitudes épistémiques et stochastiques comme support à l'ingénierie forensique. Un modèle et un outil sont présentés dans cet objectif.
description: Academic Journal of Civil Engineering, Vol 38 No 2 (2021): Special Issue - Diagnobéton 2021
Questionnaire: A survey on the demand of the database of the Yellow River governance landscape in past dynasties in China
Creators: name: Wang, Zhigang
name: Zhao, Xing
Publisher: name: Zenodo
Year: 2022
Subjects: database, Yellow River, governance landscape

description: This is a questionnaire used in a survey for the Yellow River governance researchers' recognition and opinions on the related database——the Yellow River governance landscape in China's past dynasties database during the thesis work of Zhigang Wang, Xing Zhao.
Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets: STUDIES USING CHEMICAL INHIBITORS OF LIPID PHOSPHATE PHOSPHATASE ACTIVITY
Creators: name: Wang, Zuncai
name: Morris, Andrew J.
name: Smyth, Susan S.
name: Sigal, Yury J.
name: Prestwich, Glenn D.
name: Sciorra, Vicki A.
name: Pamuklar, Zehra
name: Xu, Yong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Blood platelets play an essential role in ischemic heart disease and stroke contributing to acute thrombotic events by release of potent inflammatory agents within the vasculature. Lysophosphatidic acid (LPA) is a bioactive lipid mediator produced by platelets and found in the blood and atherosclerotic plaques. LPA receptors on platelets, leukocytes, endothelial cells, and smooth muscle cells regulate growth, differentiation, survival, motility, and contractile activity. Definition of the opposing pathways of synthesis and degradation that control extracellular LPA levels is critical to understanding how LPA bioactivity is regulated. We show that intact platelets and platelet membranes actively dephosphorylate LPA and identify the major enzyme responsible as lipid phosphate phosphatase 1 (LPP1). Localization of LPP1 to the platelet surface is increased by exposure to LPA. A novel receptor-inactive sn-3-substituted difluoromethylenephosphonate analog of phosphatidic acid that is a potent competitive inhibitor of LPP1 activity potentiates platelet aggregation and shape change responses to LPA and amplifies LPA production by agonist-stimulated platelets. Our results identify LPP1 as a pivotal regulator of LPA signaling in the cardiovascular system. These findings are consistent with genetic and cell biological evidence implicating LPPs as negative regulators of lysophospholipid signaling and suggest that the mechanisms involve both attenuation of lysophospholipid actions at cell surface receptors and opposition of lysophospholipid production.
Supplementary Table 1 from α-Amylase immobilization on amidoximated acrylic microfibres activated by cyanuric chloride.
Creators: name: Yaaser Q. Almulaiky
name: Aqlan, Faisal M.
name: Musab Aldhahri
name: Baeshen, Mohammed
name: Khan, Tariq Jamal
name: Khan, Khalid A.
name: Afifi, Mohamed
name: AL-Farga, Ammar
name: Mohiuddin Khan Warsi
name: Alkaled, Mohammed
name: Alayafi, Aisha A. M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Effect of cyanuric chloride percentage and pH on the immobilization efficiency
Localization of the Raf-like Kinase CTR1 to the Endoplasmic Reticulum of Arabidopsis through Participation in Ethylene Receptor Signaling Complexes
Creators: name: Zhao, Xue Chu
name: Kieber, Joseph J.
name: Chen, Yi Feng
name: Randlett, Melynda D.
name: Schaller, G. Eric
name: Gao, Zhiyong
name: Findell, Jennifer L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The plant hormone ethylene is perceived by a five-member family of receptors related to the bacterial histidine kinases. The Raf-like kinase CTR1 functions downstream of the ethylene receptors as a negative regulator of ethylene signal transduction. CTR1 is shown here to be associated with membranes of the endoplasmic reticulum in Arabidopsis as a result of its interactions with ethylene receptors. Membrane association of CTR1 is reduced by mutations that eliminate ethylene receptors and by a mutation in CTR1 that reduces its ability to bind to the ethylene receptor ETR1. Direct evidence that CTR1 is part of an ethylene receptor signaling complex was obtained by co-purification of the ethylene receptor ETR1 with a tagged version of CTR1 from an Arabidopsis membrane extract. The histidine kinase activity of ETR1 is not required for its association with CTR1, based on co-purification of tagged ETR1 mutants and CTR1 after expression in a transgenic yeast system. These data demonstrate that CTR1 is part of an ethylene receptor signaling complex in Arabidopsis and support a model in which localization of CTR1 to the endoplasmic reticulum is necessary for its function. Additional data that demonstrate a post-transcriptional effect of ethylene upon the expression of CTR1 suggest that production of ethylene receptor signaling complexes may be coordinately regulated.
(1712) Sarah Buckingham Pope
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Exploring Prevention and Treatment of Substance Abuse Amongst Youth in Out-of-Home Care: A Scoping Review
Creators: name: Blythe, Stacy
name: Razaghi, Kazem
name: Tellis, Gabriella
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: Foster Care
subject: Prevention
subject: Substance Abuse
subject: Treatment
subject: Young people

description: Objective: The objective of this scoping review is to provide a concise overview of current literature concerning substance abuse among adolescents aged 10 to 21 who are in foster care. This review aims to map out the existing evidence, offering valuable insights for interventions and programs designed to prevent, decrease, or halt substance misuse. Additionally, the findings aim to enhance the overall well-being of young individuals within the foster care system.
Projet SCaNING : Suivi des infrastructures neuves et existantes par Capteurs Noyés pour évaluer les Indicateurs Nécessaires à leur Gestion durable
Creators: name: Villain, Géraldine
name: Balayssac, Jean-Paul
name: Garnier, Vincent
name: Sbartaï, Mehdi
name: Yven, Béatrice
name: Hénault, Jean-Marie
name: Dérobert, Xavier
name: Chaix, Jean-François
name: Le Cam, Vincent
name: Palma Lopes, Sérgio
name: Abraham, Odile
Publisher: name: Academic Journal of Civil Engineering
Year: 2021

description: Pour une gestion durable et sûre des infrastructures de génie civil et pour en prolonger la durée d’exploitation, les gestionnaires d’ouvrages requièrent des informations qualifiées et quantitatives sur l’évolution continue des indicateurs de performance, en particulier, la résistance, le module, la porosité et la teneur en eau des bétons. Le projet ANR-SCaNING a pour objectif de développer une approche systémique du suivi de santé des structures neuves ou existantes en béton armé comprenant : la validation de capteurs noyés (électriques, électromagnétiques et ultrasonores), le traitement de la mesure et l’extraction d’observables qualifiées, découplées des principaux facteurs d’influence, la combinaison et la conversion des observables en indicateurs pour le diagnostic, ainsi que la plate-forme de supervision connectée.
description: Academic Journal of Civil Engineering, Vol 38 No 2 (2021): Special Issue - Diagnobéton 2021
Mice Lacking Phosphatidylinositol Transfer Protein-α Exhibit Spinocerebellar Degeneration, Intestinal and Hepatic Steatosis, and Hypoglycemia
Creators: name: Bankaitis, Vytas A.
name: Cortese, Jorge D.
name: Phillips, Scott E.
name: Hamilton, Bruce A.
name: Albin, Roger L.
name: Nagy, Tim R.
name: Alb Jr., James G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Phosphatidylinositol transfer proteins (PITPs) regulate the interface between lipid metabolism and cellular functions. We now report that ablation of PITP alpha function leads to aponecrotic spinocerebellar disease, hypoglycemia, and intestinal and hepatic steatosis in mice. The data indicate that hypoglycemia is in part associated with reduced proglucagon gene expression and glycogenolysis that result from pancreatic islet cell defects. The intestinal and hepatic steatosis results from the intracellular accumulation of neutral lipid and free fatty acid mass in these organs and suggests defective trafficking of triglycerides and diacylglycerols from the endoplasmic reticulum. We propose that deranged intestinal and hepatic lipid metabolism and defective proglucagon gene expression contribute to hypoglycemia in PITP alpha-/- mice, and that hypoglycemia is a significant contributing factor in the onset of spinocerebellar disease. Taken together, the data suggest an unanticipated role for PITP alpha in with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes.
(1714) Martha Buckingham [Pope]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Extraction of the proton radius from electron-proton scattering data
Creators: name: Lee, Gabriel
name: Arrington, John R.
name: Hill, Richard J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We perform a new analysis of electron-proton scattering data to determine the proton electric and magnetic radii, enforcing model-independent constraints from form factor analyticity. A wide-ranging study of possible systematic effects is performed. An improved analysis is developed that rebins data taken at identical kinematic settings, and avoids a scaling assumption of systematic errors with statistical errors. Employing standard models for radiative corrections, our improved analysis of the 2010 Mainz A1 Collaboration data yields a proton electric radius $r_E = 0.895(20)$ fm and magnetic radius $r_M = 0.776(38)$ fm. A similar analysis applied to world data (excluding Mainz data) implies $r_E = 0.916(24)$ fm and $r_M = 0.914(35)$ fm. The Mainz and world values of the charge radius are consistent, and a simple combination yields a value $r_E = 0.904(15)$ fm that is $4σ$ larger than the CREMA Collaboration muonic hydrogen determination. The Mainz and world values of the magnetic radius differ by $2.7σ$, and a simple average yields $r_M= 0.851(26)$ fm. The circumstances under which published muonic hydrogen and electron scattering data could be reconciled are discussed, including a possible deficiency in the standard radiative correction model which requires further analysis.
description: 26 pages, 10 figures, 4 supplementary data files with explanatory text. v2: As published in PRD including supplementary material. Added comparison to alternate model for correlated systematic errors and more references. Updated fit values with minor changes from v1