Additional file 1 of Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study
Creators: name: Mir, Sartaj Ahmad
name: Chen, Li
name: Burugupalli, Satvika
name: Burla, Bo
name: Ji, Shanshan
name: Smith, Adam Alexander T.
name: Narasimhan, Kothandaraman
name: Ramasamy, Adaikalavan
name: Tan, Karen Mei-Ling
name: Huynh, Kevin
name: Giles, Corey
name: Mei, Ding
name: Wong, Gerard
name: Yap, Fabian
name: Tan, Kok Hian
name: Collier, Fiona
name: Saffery, Richard
name: Vuillermin, Peter
name: Bendt, Anne K.
name: Burgner, David
name: Ponsonby, Anne-Louise
name: Lee, Yung Seng
name: Chong, Yap Seng
name: Gluckman, Peter D.
name: Eriksson, Johan G.
name: Meikle, Peter J.
name: Wenk, Markus R.
name: Karnani, Neerja
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Fig. S1. Outlier detection by principal component analysis of the lipidomics data at four time points. Fig. S2. Number of pairs between the participants in antenatal, postnatal, cord blood and child lipidomes. Fig. S3. Comparison of the results of linear regression and paired t-test. Fig. S4. Ratios of PC to PE levels and lysophospholipids (lyso-PL). Fig. S5. Scatter plots of effect sizes and adjusted p-values of plasma lipids associated with mother and child adiposity. Fig. S6. Correlation of pre-pregnancy, antenatal and postnatal maternal body mass indices (BMIs). Fig. S7. Scatter plot of effect sizes in the pre-pregnancy and antenatal BMI studies. Fig. S8. Overlapping plasma lipid signatures associated with mother and child adiposity. Fig. S9. Sex difference in the birth weight and child BMI studies. Fig. S10. Forest plots and volcano plots of the meta-analysis results in GUSTO and BIS for ppBMI and BW studies. Table S1A. Comparison of lipid classes across four sample groups (antenatal, postnatal, cord blood and 6-year-old child) using linear regression model. Table S1B. Comparison of lipids species across four sample groups (antenatal, postnatal, cord blood and 6-year-old child) using linear regression model. Table S1C. Comparison of lipids species across four sample groups (antenatal, postnatal, cord blood and 6-year-old child) using paired t-test. Table S2A. Association of lipid classes with BMI or BW in four sample groups (antenatal, postnatal, cord blood and 6-year-old child) in terms of levels. Table S2B. Association of lipid species with BMI or BW in four sample groups (antenatal, postnatal, cord blood and 6-year-old child) in terms of levels. Table S2C. Association of antenatal lipidomic profiles with antenatal BMI. Table S3A. The overlapping lipid species between the ppBMI and postnatal BMI studies. Table S3B. The overlapping lipid species between the ppBMI and birth weight studies. Table S3C. The overlapping lipid species between the birth weight and 6-year-old child BMI studies. Table S3D. The overlapping lipid species between the 6-year-old child BMI and adult (postnatal mother) BMI studies. Table S3E. Overlapping lipid species in the four lipid-adiposity association studies. Table S4A. Sex difference in the birth weight and child BMI studies in terms of lipid class levels. Table S4B. Sex difference in the birth weight and child BMI in terms of species levels. Table S5. Association studies of lipids with pre-pregnancy BMI and birth weight in Barwon Infant Study (BIS), and the meta-analysis results of GUSTO and BIS.