cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterisation of the KATRIN tritium source and evaluation of systematic effects
Creators: name: Seitz-Moskaliuk, Hendrik
Publisher: name: Karlsruhe
Year: 2019
Subjects: KATRIN
neutrino
systematic uncertainties
krypton
WGTS

description: The Karlsruhe Tritium Neutrino (KATRIN) Experiment aims to measure the effective electron antineutrino mass with a sensitivity of 200 meV (90 % C. L.) by analysing the kinematic endpoint of the tritium beta-electron spectrum. In this thesis, the systematic effects of KATRIN are evaluated. Since most of them are linked to the tritium source, the source cryostat performance is fully characterised in this work. With a dedicated measurement campaign performed with krypton-83m, energy scale-related systematic effects are investigated and the great capabilities of KATRIN in high-resolution spectroscopy of keV-scale electrons are demonstrated.
PIDs y ORCID
Creators: name: Cardoso
Publisher: name: Zenodo
Year: 2023
Subjects: PIDsLATAM23
Identificadores persistentes
PIDs
Ciencia Abierta
Persistent identifiers
Open Science

description: “Identificadores persistentes (PIDs) y ciencia abierta en Latinoamérica” (#PIDsLATAM23) organizado por DataCite, ORCID y ROR es un evento enteramente dedicado a los identificadores persistentes y la ciencia abierta en la región. Dirigido a directores y gestores de investigación, bibliotecarios y personal técnico, en este encuentro hablamos sobre los beneficios de los identificadores persistentes y cómo su adopción contribuye a la ciencia abierta y a un ecosistema de investigación más abierto y robusto. Este evento se realiza en colaboración con la csv,conf,v7. Esta presentación de Ana Cardoso ofrece una visión general de los PIDs y ORCID. -- "Persistent Identifiers (PIDs) and Open Science in Latin America" (#PIDsLATAM23) organized by DataCite, ORCID and ROR is an event entirely dedicated to persistent identifiers and open science in the region. Aimed at research directors and managers, librarians and technical staff, in this meeting we talk about the benefits of persistent identifiers and how their adoption contributes to open science and a more open and robust research ecosystem. This event is held in collaboration with csv,conf,v7. This presentation by Ana Cardoso provides an overview of PIDs and ORCID.
(Empidideicus) Becker
Creators: name: Gharali, Babak
name: Evenhuis, Neal L.
name: Moghbeli, Sajjad
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Mythicomyiidae

description: Subgenus Empidideicus Becker
Empidideicus Becker, 1907: 97 (as genus). Type species: Empidideicus carthaginiensis Becker, 1907, by monotypy.
description: Published as part of Gharali, Babak, Evenhuis, Neal L. & Moghbeli, Sajjad, 2025, Three new species of the genus Empidideicus Becker, 1907 (Diptera, Mythicomyiidae) from Iran with the first record of the subgenus Cyrtoides Engel, 1933, pp. 529-541 in Zootaxa 5604 (4) on page 535, DOI: 10.11646/zootaxa.5604.4.5, http://zenodo.org/record/15214128
Investigating Multiple Modifier Network Candidates as Suppressors of zyg-1/PLK4 in C. elegans
Creators: name: Stuart, Amanda Rhae
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Modifiers
subject: Genomics
subject: Modifier Networks
subject: Genetics
subject: FOS: Biological sciences
subject: Physics--Molecular

description: Genetic modifiers are second-site alleles that affect the function or regulation of a primary allele to either suppress or enhance the associated phenotype. The traditional methods of identifying and studying these modifying interactions have been useful for the consistent elucidation of single modifier activities, which has expanded the known single gene interactions significantly. However, these methods have been limited in their capability to identify true cases of modifier networks within a genome because of the use of backcrossing to minimize the regions of the genome to be examined for modifiers. By limiting our knowledge of multiple modifier networks, we lack knowledge on the intrinsic complexities of the genome, and how the larger genomic context may be influencing phenotypic outcomes. This thesis explores the use of high-throughput mutagenesis-based suppressor screen methods of a temperature-sensitive, lethal C. elegans allele, zyg-1(it25); these methods include whole genome sequencing and bioinformatic analyses without backcrossing steps, followed by candidate modifier validation using CRISPR/Cas9 methods to study potential multiple modifier networks. Our results show that ~20% of all mutagenized strains have more than one candidate modifier identified after bioinformatic analysis, and CRISPR/Cas9 validation of the candidate networks derived from four mutagenized strains showed that 50% of tested strains carried true multiple modifier networks. Six individual modifier alleles of zyg-1(it25) were validated while testing the candidate networks, including a novel suppressor. Furthermore, study of the candidate alleles in a wild-type background showed that all modifying variants induced their own phenotype, reducing the population viability of these strains. Finally, this study explores the mechanism for suppression of zyg-1(it25) from the validated modifiers, most of which are components of the Anaphase Promoting Complex; all modifying variants show delays of the cell cycle, particularly of anaphase-onset, indicating that increased mitotic time is allowing embryos to overcome deficiencies of ZYG-1. With the ZYG-1 human ortholog, PLK4, being implicated in symptomatic microcephaly, elucidation of the modifier networks and phenotype-altering interaction may lead to further understanding of the mechanisms that cause developmental microcephaly and can have expanded applications to other genetic diseases.
Short-range nuclear effects on axion emissivities by nucleon-nucleon bremsstrahlung
Creators: name: Stoica, S.
name: Pastrav, B.
name: Scafes, A. C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Theory (nucl-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The rates of axion emission by nucleon-nucleon (NN) bremsstrahlung are reconsidered by taking into account the NN short range correlations. The analytical formulas for the neutron-neutron (nn), proton-proton (pp) and neutron-proton (np) processes with the inclusion of the full momentum dependence of an one- and two- pion exchange nuclear potentials, in the non-degenerate limit, are explicitly given. We find that the two-pion exchange (short range) effects can give a significant contribution to the emission rates, and are temperature dependent. Other short range nuclear effects like effective nucleon mass, polarization effects and use of correlated wave functions, are discused as well. The trend of all these nuclear effects is to diminish the corresponding axion emission rates. Further, we estimate that the values of the emission rates calculated with the inclusion of all these effects can differ from the corresponding ones derived with constant nuclear matrix elements by a factor of $\sim 24$. This leads to an uncertainty factor of $\sim 4.9$ when extracting bounds of the axion parameters
description: 11 pages, 4 figures
Social Integration Experiences of Young Newcomers in Canadian High Schools and the Importance of Friendship
Creators: name: Ahmed, Solafa
Publisher: name: Werklund School of Education
Year: 2022
Subjects: subject: Social integration
subject: Intercultural friendship
subject: Newcomer students
subject: High school
subject: Educational Psychology
subject: Education--Guidance and Counseling
subject: Psychology--Social

description: As the population of young newcomers (immigrants, refugees and international students) increases in Canada, there is a growing need to understand the social integration process of these students into Canadian schools. This thesis reports a qualitative analysis of how newcomer students in three Canadian schools perceived their experiences interacting with local students. I explored two research questions: (1) What do newcomers perceive as factors that hinder intercultural friendships with local students? (2) How should the notion of social integration be re-conceptualized based on newcomers’ experiences? The data analyzed was derived from a larger project by Zhao et al. (2017), which aimed to establish a conceptual framework for understanding intercultural friendship formation in Canadian high schools. I used the thematic analysis (TA) approach to analyze interviews and identify themes and subthemes to address the research questions. Participants of the interviews included in my analysis were 19 newcomer students from three high schools in Alberta. Despite newcomer students’ strong motivations to socially connect with local students, several barriers prevented this. In addition to a lack of English proficiency, newcomer students lacked the confidence to have conversations with local students and preferred to interact with other newcomers because of their shared status, identity, and experiences as newcomers. Participants believed local students were not interested in them and/or were intolerant of their English language struggles. This study provides new evidence of the psychological and social challenges that hinder the social integration of young newcomers in Canadian schools. I also critically examined the conceptualization of the term social integration and its current implications.
A test for cosmic distance duality
Creators: name: Holanda, R. F. L.
name: Goncalves, R. S.
name: Alcaniz, J. S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Testing the cosmic distance duality relation (CDDR) constitutes an important task for cosmology and fundamental physics since any violation of it would be a clear evidence of new physics. In this {\it Letter}, we propose a new test for the CDDR using only measurements of the gas mass fraction of galaxy clusters from Sunyaev-Zeldovich ($f_{SZE}$) and X-ray surface brightness ($f_{X-ray}$) observations. We show that the relation between current $f_{X-ray}$ and $f_{SZE}$ observations is given by $f_{SZE}=ηf_{X-ray}$, where $η$ quantifies deviations from the CDDR. Since this latter expression is valid for the same object in a given galaxy cluster sample, the method proposed removes possible contaminations from different systematics error sources and redshift differences involved in luminosity and angular diameter distance measurements. We apply this cosmological model-independent methodology to the most recent $f_{X-ray}$ and $f_{SZE}$ data and show that no significant violation of the CDDR is found.
description: 5 pages, 3 figures, uses revtex4
The effect of exercise on the concentration of platelets in a platelet rich plasma preparation
Creators: name: Forsyth, Sara
Publisher: name: University of British Columbia
Year: 2012

description: Traumatic tendon injuries and tendinopathy are common problems in sports medicine practice. The active population seeks minimally invasive treatments that speed healing time. New strategies, such as platelet-rich plasma (PRP) therapies, may achieve this. The use of PRP in sports medicine has been stimulated by the advancing knowledge regarding the role of growth factors (GF) in tissue repair. GF concentration is thought to increase linearly with platelet concentration (Eppley et al., 2004). Several studies are emerging with favourable outcomes in injection of PRP into the area of injury (Kon et al., 2009, Mishra & Pavelko, 2006). Some postulate that the greater the concentration of platelets in a sample the greater the healing augmentation (Smith, 2009). There is a lack of literature addressing the clinically practical issue of how to best maximize the platelet-enhanced product drawn from the patient. The purpose of this study was to evaluate the effect of 2 exercise intensities on the concentration of platelets in a PRP preparation. The participants exercised on a cycle ergometer on three occasions. First, a V0₂max test was carried out. The participant then exercised, on two separate days, for 15 minutes at 50% (moderate exercise) or at 85% (intense exercise) of their predetermined V0₂max heart rate. Blood was drawn at baseline and within 3 minutes post exercise. The samples were prepared into a PRP preparation. The concentration of platelets was analyzed in the PRP. We found a significant increase in the concentration of platelets in the post-intense exercise PRP samples. No significant increase was seen in the moderate exercise condition. A significant effect was found for the mean differences between pre and post in the moderate versus intense exercise groups. These results indicate that intense exercise is a practical and safe way to increase the concentration of platelets in a PRP sample.
Additional file 1 of Development and external validation of a breast cancer absolute risk prediction model in Chinese population
Creators: name: Han, Yuting
name: Lv, Jun
name: Yu, Canqing
name: Guo, Yu
name: Bian, Zheng
name: Hu, Yizhen
name: Yang, Ling
name: Chen, Yiping
name: Du, Huaidong
name: Zhao, Fangyuan
name: Wen, Wanqing
name: Shu, Xiao-Ou
name: Xiang, Yongbing
name: Gao, Yu-Tang
name: Zheng, Wei
name: Guo, Hong
name: Liang, Peng
name: Chen, Junshi
name: Chen, Zhengming
name: Huo, Dezheng
name: Li, Liming
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1. Show comparison of Age-adjusted RR (95% CI) for breast cancer among women in urban and rural areas of China Kadoorie Biobank.
Pain and Cerebral Blood Flow in Children Shortly After Mild Traumatic Brain Injury Compared to Orthopedic Injury
Creators: name: Kwan, Vivian
Publisher: name: Science
Year: 2022
Subjects: subject: mild traumatic brain injury
subject: pediatrics
subject: arterial spin labeling
subject: concussion
subject: cerebral blood flow
subject: pain
subject: headache
subject: Psychology
subject: FOS: Psychology
subject: Psychobiology

description: Aims: The aims of the current study are to: (1) examine pain ratings in children following mild traumatic brain injury (mild TBI) compared to a control group of orthopedic injury (OI), (2) compare cerebral blood flow (CBF) approximately 10 days post-injury between the two injury groups, and (3) investigate the association between children’s pain ratings and CBF to determine whether the association may vary depending on the type of injury (mild TBI vs OI). Methods: This was a prospective study of children and adolescents ages 8-16 years following mild TBI (n = 374) or OI (n = 202) recruited from emergency departments across five sites in Canada (Calgary, Edmonton, Montreal, Ottawa, Vancouver). They were assessed at a post-acute follow-up approximately 7 days post-injury. They rated pain intensity (“Over the past week, how much hurt do you have?”) from 0 (no pain) to 10 (worst pain possible) and pain unpleasantness (“how much do aches or pains bother you?”) from 0 (not at all) to 4 (very much). CBF was measured using arterial spin labeling (ASL) with a pseudo-continuous (Calgary, Montreal GE, Vancouver) or pulsed approach (Edmonton, Montreal Siemens, Ottawa). Results: Children with mild TBI reported significantly higher pain intensity (M = 4.77, SD = 2.38 versus M = 4.01, SD = 2.26, η2 = 0.015) and unpleasantness (M = 1.78, SD = 1.02 versus M = 1.30, SD = 0.89, η2 = 0.029) compared to children with OI. Final CBF analyses were focused on data from Calgary and Vancouver, given quality concerns with data from other scanners. Absolute CBF, but not relative CBF, was significantly lower in the mild TBI than OI group (η2 ranged from 0.017 to 0.041) across all seven regions of interest (ROI) and global grey matter, after correcting for multiple comparisons. Relative CBF in four ROIs in the parietal lobe (intraparietal sulcus, inferior parietal lobe, primary somatosensory cortex, and superior parietal lobe) were significant predictors of children’s pain intensity ratings, but only in the OI group, and not the mild TBI group. Conclusions: Absolute CBF was decreased in the mild TBI compared to OI group. There was no clear association between children’s pain ratings and absolute or relative CBF after mild TBI. More research is needed to better understand the pathophysiology of vascular changes following mild TBI, and how these changes may be related to pain, post-concussive symptoms, and other aspects of functioning.
Probing multipartite entanglement in a coupled Jaynes-Cummings system
Creators: name: Xue, Peng
name: Ficek, Zbigniew
name: Sanders, Barry C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show how to probe multipartite entanglement in $N$ coupled Jaynes-Cummings cells where the degrees of freedom are the electronic energies of each of the $N$ atoms in separate single-mode cavities plus the $N$ single-mode fields themselves. Specifically we propose probing the combined system as though it is a dielectric medium. The spectral properties and transition rates directly reveal multipartite entanglement signatures. It is found that the Hilbert space of the $N$ cell system can be confined to the totally symmetric subspace of two states only that are maximally-entangled W states with 2N degrees of freedom.
η and η' mesons from Nf=2+1+1 twisted mass lattice QCD
Creators: name: Ottnad, K.
name: Michael, C.
name: Reker, S.
name: Urbach, C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We determine mass and mixing angles of eta and eta' states using Nf=2+1+1 Wilson twisted mass lattice QCD. We describe how those flavour singlet states need to be treated in this lattice formulation. Results are presented for three values of the lattice spacing, a=0.061 fm, a=0.078 fm and a=0.086 fm, with light quark masses corresponding to values of the charged pion mass in a range of 230 to 500 MeV and fixed bare strange and charm quark mass values. We obtain 557(15)(45) MeV for the eta mass (first error statistical, second systematic) and 44(5) degrees for the mixing angle in the quark flavour basis, corresponding to -10(5) degrees in the octet-singlet basis.
description: 28 pages, 9 figures, version to appear in JHEP, extended discussion of autocorrelation times and comparison to results available in the literature, added a comment for FS-effects and clarified the description of our blocking procedure
Five-year-olds’ Social Preferences and Cultural Inferences About Foreign-Accented Speakers
Creators: name: Zepeda, Michelle
Publisher: name: Arts
Year: 2022
Subjects: subject: accent
subject: social categories
subject: Psychology--Clinical
subject: Psychology--Cognitive

description: Two experiments investigated whether five-year-olds’ accent-based cultural inferences and social preferences varied depending on the information provided about the speakers, and whether they were associated with children’s linguistic experiences. In each experiment, 96 five-year-olds were randomly assigned to one of three between-subjects conditions. First, children were introduced to a native-accented speaker and a foreign-accented speaker and were taught limited information about both (i.e., the colours of their notebooks). Next, children in the baseline conditions proceeded to the test trials. In the differences minimized and differences maximized conditions, children were first taught cultural information about the speakers. In the differences minimized conditions, both speakers were associated with cultural items (i.e., food and clothing) that were familiar. In the differences maximized condition, the two speakers were associated with different cultural items (i.e., the native-accented speaker with the familiar object, foreign-accented with the less familiar object). In the cultural inference trials, children were asked which item matched the speaker’s voice (i.e., the voice of the native or foreign-accented speaker). In the social preference trials, children were asked to indicate which of the two speakers they wanted as a friend. Finally, parents completed a language and accent questionnaire. Methodological considerations were identified in Experiment 1 and changes to the design of the study were implemented in Experiment 2. In Experiment 1, children’s selections did not differ as a function of the information provided to them on either the cultural inference or social preference tasks. In Experiment 2, children’s cultural inferences about foreign-accented speakers varied across the differences minimized and maximized conditions (i.e., children in the differences minimized condition selected significantly more familiar cultural items). Moreover, across all conditions, children associated familiar objects more with the native-accented speaker and unfamiliar objects with the foreign-accented speaker. In the social preference task, children in the differences maximized condition preferentially selected the native-accented speaker on an initial trial. Finally, no association emerged between children’s linguistic experiences and their accent-based cultural inferences and social preferences. Together, the results of these experiments offer insight into the conditions under which children’s accent-based inferences and social preferences are modulated.
Nonlinear Tides in Close Binary Systems
Creators: name: Weinberg, Nevin N.
name: Arras, Phil
name: Quataert, Eliot
name: Burkart, Josh
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We study the excitation and damping of tides in close binary systems, accounting for the leading order nonlinear corrections to linear tidal theory. These nonlinear corrections include two distinct effects: three-mode nonlinear interactions and nonlinear excitation of modes by the time-varying gravitational potential of the companion. This paper presents the formalism for studying nonlinear tides and studies the nonlinear stability of the linear tidal flow. Although the formalism is applicable to binaries containing stars, planets, or compact objects, we focus on solar type stars with stellar or planetary companions. Our primary results include: (1) The linear tidal solution often used in studies of binary evolution is unstable over much of the parameter space in which it is employed. More specifically, resonantly excited gravity waves are unstable to parametric resonance for companion masses M' > 10-100 M_Earth at orbital periods P = 1-10 days. The nearly static equilibrium tide is, however, parametrically stable except for solar binaries with P < 2-5 days. (2) For companion masses larger than a few Jupiter masses, the dynamical tide causes waves to grow so rapidly that they must be treated as traveling waves rather than standing waves. (3) We find a novel form of parametric instability in which a single parent wave excites a very large number of daughter waves (N = 10^3[P / 10 days]) and drives them as a single coherent unit with growth rates that are ~N times faster than the standard three wave parametric instability. (4) Independent of the parametric instability, tides excite a wide range of stellar p-modes and g-modes by nonlinear inhomogeneous forcing; this coupling appears particularly efficient at draining energy out of the dynamical tide and may be more important than either wave breaking or parametric resonance at determining the nonlinear dissipation of the dynamical tide.
description: 40 pages, 16 figures. Matches version published in ApJ; conclusions unchanged; some restructuring of sections; sect. 5 now provides simple physical estimates of the nonlinear growth rates that agree well with the detailed calculations given in the appendices
The Colourful World of Platyrrhine Monkeys: Skin Colour Variation and Its Potential Role in Communication
Creators: name: Alves Antonio Moreira Pacheco, Lais
Publisher: name: Arts
Year: 2022
Subjects: subject: colour vision
subject: Platyrrhines
subject: communication
subject: spider monkeys
subject: tamarins
subject: Anthropology
subject: FOS: Sociology
subject: Biology

description: Understanding the evolution of human communication has been a longstanding goal of anthropologists and has spurred many lines of research. Studying our closest living relatives, the non-human primates (NHPs), provides an opportunity to better understand human communication, by placing it in a comparative context. Among NHPs, use of colour signals is common and widely distributed across the Order. Catarrhines have trichromatic colour vision and exposed skin colouration plays an important role in their interactions. In platyrrhines, exposed skin is less common, but some genera have widely exposed body regions, suggesting that skin colouration might also be used for communication. Intriguingly, platyrrhines have polymorphic colour vision, in which some individuals are dichromats while others are trichromats. This polymorphism may affect signal perception by conspecifics and shape some aspects of communication. However, we currently lack studies measuring colour (hue, saturation, chroma) variation in their skin. In this thesis, I provide several studies that seek to explore the potential for colour signals in platyrrhines. I provide the first analysis of the distribution and evolution of facial skin exposure and colour in platyrrhines in Chapter 2. I then report in Chapter 3 variation in facial skin colour of golden lion tamarins (Leontopithecus rosalia) in the context of breeding status, reproductive condition, and age. In Chapter 4, I investigate if female genital skin colour of two species of wild tamarins [saddleback (Leontocebus weddelli) and emperor tamarins (Saguinus imperator)] vary between developmental classes. Finally, I study the hypertrophied and pendulous clitoris of female black-handed spider monkeys (Ateles geoffroyi) and investigate if its colour and shape varies within and between individuals. My results suggest that among platyrrhines there is extensive variation in skin exposure and colouration and that colour seems to be linked to breeding status, reproductive condition and age in some species, and colour variation occurs within and between individuals. These results show potential for convergence in some functions of bare-skin signaling in catarrhine primates. My Doctoral Thesis makes contributions to the understanding of primate communication by adding new comparative data to illuminate the selective pressures shaping the sensory and communication systems across our order.
title: 5-Formylcytosin ist vermutlich eine semi-permanente Base an definierten Genompositionen
Creators: name: Su, Meng
name: Kirchner, Angie
name: Stazzoni, Samuele
name: Müller, Markus
name: Wagner, Mirko
name: Schröder, Arne
name: Carell, Thomas
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2016
Subjects: subject: Epigenetische Base; Click-Chemie; 5-Formylcytosine; Genomische DNA; Droplet Digital PCR
subject: 540
subject: 570

description: Die epigenetische Base 5-Formyl-2’-desoxycytosin (fdC) wurde kürzlich im Genom von Stammzellen entdeckt. Ihre Funktion ist bisher jedoch unbekannt. Daten aus Genomsequenzierungen zeigen eine Anreicherung in CpG Inseln von Promotoren, weshalb eine Beteiligung an der Regulation der Transkription während der zellulären Differenzierung angenommen wird. Auch ist fdC dafür bekannt von dem Enzym Thymin-DNA-Glykosylase (Tdg) erkannt und ausgeschnitten zu werden. Folglich wird angenommen, dass fdC als Intermediat während der aktiven Demethylierung auftritt. Um die Funktion der neuen epigenetischen Base fdC zu verstehen, ist es von großer Bedeutung dessen Bildung und Entfernung an definierten genomischen Positionen analysieren zu können. Im Folgenden beschreiben wir eine neue derartige Methode, die sequenzspezifische, chemische Derivatisierung von fdC mit Droplet Digital PCR kombiniert. Erste Ergebnisse zeigen, dass das Reparaturprotein Tdg nur 50% der fdCs an einer bestimmten Position im Genom entfernt, was auf semi-permanente Eigenschaften dieser Base hinweist.
Additional file 2 of Development and external validation of a breast cancer absolute risk prediction model in Chinese population
Creators: name: Han, Yuting
name: Lv, Jun
name: Yu, Canqing
name: Guo, Yu
name: Bian, Zheng
name: Hu, Yizhen
name: Yang, Ling
name: Chen, Yiping
name: Du, Huaidong
name: Zhao, Fangyuan
name: Wen, Wanqing
name: Shu, Xiao-Ou
name: Xiang, Yongbing
name: Gao, Yu-Tang
name: Zheng, Wei
name: Guo, Hong
name: Liang, Peng
name: Chen, Junshi
name: Chen, Zhengming
name: Huo, Dezheng
name: Li, Liming
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 2. Show age- and residence-specific breast cancer incidence rates and mortality rates of non-breast cancer per 100,000 person-years by data sources.
Natural Predictions for the Higgs Boson Mass and Supersymmetric Contributions to Rare Processes
Creators: name: Li, Tianjun
name: Maxin, James A.
name: Nanopoulos, Dimitri V.
name: Walker, Joel W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the context of No-Scale F-SU(5), a model defined by the convergence of the F-lipped SU(5) Grand Unified Theory, two pairs of hypothetical TeV scale vector-like supersymmetric multiplets with origins in F-theory, and the dynamically established boundary conditions of No-Scale Supergravity, we predict that the lightest CP-even Higgs boson mass lies within the range of 119.0 GeV to 123.5 GeV, exclusive of the vector-like particle contribution to the mass. With reports by the CMS, ATLAS, CDF, and D0 Collaborations detailing enticing statistical excesses in the vicinity of 120 GeV in searches for the Standard Model Higgs boson, all signs point to an imminent discovery. While basic supersymmetric constructions such as mSUGRA and the CMSSM have already suffered overwhelming reductions in viable parameterization during the LHC's initial year of operation, about 80% of the original No-Scale F-SU(5) model space remains viable after analysis of the first 1.1 fb^{-1} of integrated luminosity. This model is moreover capable of handily explaining the small excesses recently reported in the CMS multijet supersymmetry search, and also features a highly favorable "golden" subspace which may simultaneously account for the key rare process limits on the muon anomalous magnetic moment (g - 2) and the branching ratio of the flavor-changing neutral current decay b to sγ. In addition, the isolated mass parameter responsible for the global particle mass normalization, the gaugino boundary mass M_{1/2}, is dynamically determined at a secondary local minimization of the minimum of the Higgs potential V_{min}, in a manner which is deeply consistent with all precision measurements at the physical electroweak scale.
description: Physics Letters B Version, 10 pages, 2 figures, 2 tables
Flowing material balance applicability to low-permeability Coalbed methane reservoirs
Creators: name: Medina, Maria Camila
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Flowing material balance (FMB)
subject: Coalbed methane reservoirs
subject: Rate Transient Analysis (RTA)
subject: Engineering
subject: Engineering--Petroleum

description: Coal has been developed and used as an energy source for centuries, but the methane associated with coal (‘coalbed methane’, CBM) is among the most recent energy sources to be exploited, along with tight and shale gas reservoirs. Coalbed is a naturally fractured reservoir in which gas storage is mainly controlled by adsorption. Gas flow occurs via diffusion in the matrix (Fick’s law) and laminar flow (Darcy’s law) in the fractures, also known as cleats. Reservoir characterization of CBM reservoirs is challenging because of the complex properties of coal. While core, log and well testing methods have been developed specifically for coal, quantification of, for example, gas in place is complicated due to the existence of adsorbed gas. Numerical simulation history matching can be applied to CBM reservoirs to obtain CBM reservoir properties, but model setup and execution is time consuming, and substantial information is required. Flowing material balance (FMB) is a production analysis method that uses production rates and flowing pressures of a well to estimate original fluids in place. FMB methods have been developed and successfully applied to high permeability saturated (two-phase gas and water flow, below desorption pressure) and undersaturated (single-phase water flow above desorption pressure; two-phase gas and water flow below desorption pressure) coalbed methane reservoirs to obtain estimates of original fluid in place. However, their applicability to low permeability (<10 md) CBM reservoirs is more challenging due to the complication of requiring a saturation-pressure relationship for calculating pseudo-pressures used in FMB calculations. A new FMB model suggested by Clarkson & Salmachi (2017), developed for high permeability undersaturated/saturated CBM reservoirs, does not require a saturation-pressure relationship. The applicability of this method to low-permeability saturated coalbed methane reservoirs is examined in this thesis. For this purpose, simulated cases were generated for a range of permeability values. In some simulation cases, non-static permeability (a function of stress and desorption) was also included in the simulation model to test the accuracy of the Clarkson & Salmachi (2017) method for such cases. In all test cases, including cases with initial permeabilities equal to 0.5 md, the Clarkson & Salmachi (2017) FMB method resulted in gas in place estimates consistent with numerical model input.
Pre-season Screening and Injury Surveillance of Pre-Professional Dancers: A Longitudinal Study
Creators: name: Critchley, Meghan
Publisher: name: Kinesiology
Year: 2022
Subjects: subject: Dance
subject: Injury
subject: Epidemiology
subject: Dance
subject: Epidemiology

description: Few dance epidemiology studies have utilized evidence-based pre-season screening measures, prospective injury surveillance, and biostatistical modelling to investigate potential risk factors for dance-related injury across multiple years. Post-injury there is currently no return-to-dance protocol to guide injury rehabilitation. A dance-specific jump test to detect lower-limb asymmetries and normative values for common pre-season screening assessments may prove useful for onsite clinicians who are responsible for dancer populations. Therefore, the aims of this doctoral research were to assess the prevalence, incidence, and risk factors for dance-related injury in pre-professional ballet dancers, to evaluate the test-retest reliability of a dance specific jump test using wearable technology, and to establish normative values for common pre-season screening assessments. In Chapter three, it was found that injury prevalence, injury rate, severity, and location remain consistent across five years of training, further justifying the growing body of research that demonstrates pre-professional ballet dancers are at high risk for injury. In an examination of potential risk factors in Chapter four, a significant association between lumbopelvic control and dynamic balance, when adjusted for psychological coping skills and years of previous dance training, with side-to-side differences was found. In Chapter five, findings demonstrated that using accelerometers during a dance-specific jump test did not produce reliable measures of lower limb landing asymmetries. However, test-retest reliability was demonstrated for performance measures (i.e., flight time and jump height). This means that inertial measurement units placed on the lower limb could be used to quantify jump loads and measure jump height performance during injury rehabilitation. Finally, in chapter six, normative values and percentiles were determined for ankle and hip range of motion, lumbopelvic control, and dynamic balance for healthy, adolescent ballet dancers training at the pre-professional level. In conclusion, the use of a comprehensive injury surveillance program across multiple years has established consistent risks and a risk profile for dance-related injury in pre-professional dancers. Baseline and normative values of jump performance and common pre-season screenings may be a more appropriate reference for injury than lower-limb asymmetry metrics.
Directed search for differentiated goods
Creators: name: Huang, Ce
Publisher: name: University of British Columbia
Year: 2012

description: In three directed search models with horizontal differentiation, this thesis characterizes the unique symmetric equilibrium for each model and studies the welfare property of equilibrium allocations. In Chapter 2, horizontal differentiation is modeled as buyers' valuations being independent. In equilibrium, sellers use a mixed strategy with the support consisting of a countable number of prices. Equilibrium price dispersion exists and equilibrium allocation is constrained inefficient due to price dispersion. Chapter 3 extends the model in Chapter 2 by allowing different degrees of horizontal differentiation. With large degrees of horizontal differentiation, sellers use a mixed strategy qualitatively similar to the equilibrium in Chapter 2. With small degrees of differentiation, sellers use a pure strategy. Chapter 4 extends the model in Chapter 2 by allowing differentiation to be endogenous. Initially buyers are equally uncertain about the characteristics of sellers' goods and no differentiation exists. Then sellers choose prices together with the amounts of information disclosed to buyers about the characteristics of sellers' goods. Information disclosure leads to differentiation after buyers receive the information. It is shown that a seller's profit by disclosing full information is higher than that by disclosing partial information. In equilibrium both sellers disclose full information and use a pricing strategy that is identical to the equilibrium in Chapter 2.
Vanishing of the anomalous Hall effect and enhanced carrier mobility in the spin-gapless ferromagnetic Mn2CoGa1-xAlx alloys
Creators: name: Zhang, Cheng
name: Pan, Shuang
name: Wang, Peihao
name: Men, Yuchen
name: Li, Xiang
name: Bai, Yuqing
name: Tang, Li
name: Xu, Feng
name: Xu, Guizhou
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Spin gapless semiconductor (SGS) has attracted long attention since its theoretical prediction, while concrete experimental hints are still lack in the relevant Heusler alloys. Here in this work, by preparing the series alloys of Mn2CoGa1-xAlx (x=0, 0.25, 0.5, 0.75 and 1), we identified the vanishing of anomalous Hall effect in the ferromagnetic Mn2CoGa (or x=0.25) alloy in a wide temperature interval, accompanying with growing contribution from the ordinary Hall effect. As a result, comparatively low carrier density (1020 cm-3) and high carrier mobility (150 cm2/Vs) are obtained in Mn2CoGa (or x=0.25) alloy in the temperature range of 10-200K. These also lead to a large dip in the related magnetoresistance at low fields. While in high Al content, despite the magnetization behavior is not altered significantly, the Hall resistivity is instead dominated by the anomalous one, just analogous to that widely reported in Mn2CoAl. The distinct electrical transport behavior of x=0 and x=0.75 (or 1) is presently understood by their possible different scattering mechanism of the anomalous Hall effect due to the differences in atomic order and conductivity. Our work can expand the existing understanding of the SGS properties and offer a better SGS candidate with higher carrier mobility that can facilitate the application in the spin-injected related devices.
Development of Rapid, Low-cost, and Portable Device to Detect Infectious Diseases
Creators: name: Lee, Yoonjung
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: COVID-19
subject: Engineering--Mechanical

description: With the spread of COVID-19, which started the global pandemic in 2019 and continues to be prevalent these days, the importance of developing effective diagnostic methods to limit the spread of infectious diseases has emerged. The standard method used to diagnose severe acute respiratory syndrome coronavirus 2 is reverse transcriptase polymerase chain reaction (RT-PCR). Still, its disadvantages include high cost, complex equipment, and long diagnostic time. This study developed two loop-mediated isothermal amplification (LAMP) based diagnostic methods (Saliva-Dry LAMP and Direct Dry-LAMP) which are rapid, sensitive, and near-patient to overcome the limitations of RT-PCR. Saliva-Dry LAMP has the advantages of the LAMP method and requires saliva samples using a customized portable all-in-one box. Direct Dry-LAMP has a more rapid detection time with a heat inactivation step instead of RNA extraction, and the customized device can be executed with batteries and the developed application. The development of these devices reduces the capital cost of instruments significantly, and both methods have shown great performances with excellent positive percent agreement and negative percent agreement compared to each reference RT-PCR. Another convection-based device combined with real-time detection was developed to perform Direct Dry-LAMP. Although this device is still in development, it underscores the growing need for a random-access platform with real-time detection. Overall, Saliva-Dry LAMP and Direct Dry-LAMP can provide rapid and accurate detection of COVID-19 with portable and low-cost devices. With more widespread use, both these methods could play a central role in efficiently limiting the spread of infectious diseases, especially in resource-limited regions.
Nambu-Goldstone dynamics and generalized coherent-state functional integrals
Creators: name: Blasone, Massimo
name: Jizba, Petr
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The present paper gives a new method of attack on the Nambu-Goldstone dynamics in spontaneously broken theories. Since the target space of the Nambu-Goldstone fields is a group coset space, their effective quantum dynamics can be naturally phrased in terms of generalized coherent-state functional integrals. As an explicit example of this line of reasoning we construct a low-energy effective Lagrangian for the Heisenberg ferromagnet in broken phase. The leading field configuration in the WKB approximation leads to the Landau-Lifshitz equation for quantum ferromagnet. The corresponding linearized equations allow to identify the Nambu-Goldstone boson with ferromagnetic magnon.
description: 17 pages, IOP LaTeX, revised version with minor changes, accepted to J. Phys. A: Math. Theor
Metabolite-Sensing Transcription Factors for Developing Whole Cell Naphthenic Acid Biosensor Technology
Creators: name: Bookout, Tyson
Publisher: name: Science
Year: 2022
Subjects: subject: Biosensor
subject: Tailings ponds
subject: Naphthenic Acids
subject: Transcription factors
subject: Environmental Monitoring
subject: Microbiology
subject: FOS: Biological sciences
subject: Biology--Molecular

description: Naphthenic Acids (NA) are a complex group of acyclic and cyclic alkyl-substituted carboxylic acids. These compounds are naturally produced during the degradation of petroleum and are present in high concentrations in the waste produced during the bitumen extraction process. NAs are very toxic, and monitoring and treating the oil sands process-affected water (OSPW) is costly and time-consuming. Whole cell biosensors are a proven technology holding the potential for a rapid and low-cost method of monitoring NA in tailings ponds. We are exploiting the sensitive and reliable detection mechanisms present in bacterial cells for inducing appropriate responses to environmental changes, by engineering bacterial strains to produce a simple and quantitative output in proportion to NA. Using bacterial genomics and synthetic biology, we designed transcription factor-based biosensors using a novel Pseudomonas species isolated from the OSPW, by examining the upregulated genes in the presence of different NA mixtures. The promoters of these genes are then synthesized and cloned directly upstream from a bacterial lux operon, that is used as a bioluminescent reporter. We are particularly interested in those involved in transcriptional regulation, antibiotic efflux, or bioremediation. We have identified three strong promoters for NA-detection: a promoter driving the expression of a hypothetical gene, a divergent NA-inducible promoter from the atu operon regulated by a TetR family repressor, and a promoter for a toxic RND efflux system regulated by a MarR family regulator. These transcriptional regulators bind within the promoter sequence to repress gene expression, unless in the presence of a target analyte. Upon analyte binding, a confirmational change occurs to release the protein from the promoter region and allow transcription. Using electrophoretic mobility shift assays, this mechanism of promoter repression and NA detection was confirmed for both AtuR and MarR regulators. Through lux expression experiments, the hypothetical promoter, divergent atu promoter, and MarR regulated promoter were confirmed to sensitively respond in a dose-dependent manner to a custom mixture of NA compounds, a mixture of primarily acyclic NAs, and the complex OSPW mixture, respectively. These biosensors are sensitive within 2-30 parts per million, and the capability of these biosensors to uniquely respond to NA compounds and not other hydrocarbons such as alkanes and BTEX, demonstrates the potential for using a panel of these biosensors for detecting NA toxicity in the environment.