cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Présence de facteurs de risque de douleur d’épaule chez les jeunes nageurs de compétition
Creators: name: Robert, Lauriane
name: Hugon, Alexandra
Publisher: name: Unknown
Year: 0
Subjects: subject: Facteur de risque
subject: douleur d’épaule
subject: natation
subject: jeunes
subject: dysbalance musculaire
subject: amplitude articulaire
subject: laxité

description: Introduction : La natation impose au complexe de l’épaule de nombreux microtraumatismes de par sa biomécanique et sa nature répétitive. Ce travail de Bachelor, basé sur les principes d’une revue de la littérature, vise à déterminer si, parmi les facteurs de risque de douleurs d’épaule avérés chez les nageurs de compétition adultes, certains sont déjà présents chez les jeunes nageurs. En effet, à ce jour, aucun consensus ne semble exister à ce sujet dans cette population. Méthodologie : Des recherches ont été effectuées sur les bases de données Pubmed, Cinahl, PEDro, Cochrane library et ScienceDirect entre juillet 2015 et février 2016. Au final, 6 articles ont été retenus. Leur qualité méthodologique a été évaluée à partir de la grille McMaster. Résultats : Les scores de qualité méthodologique des articles retenus varient de 8/13 à 10/13. Les facteurs de risque déjà présents chez les jeunes nageurs sont : la diminution d’amplitude en rotation interne, l’augmentation de force en rotation interne et la diminution du ratio de force RE/RI. Conclusion : Ce travail a permis d’identifier deux facteurs de risque déjà présents chez les jeunes nageurs de compétition. Les autres facteurs de risque nécessitent de plus amples investigations. Afin d’appuyer ces résultats, il est indispensable d’effectuer des études sur des populations de jeunes nageurs, en intégrant des interventions agissant sur ces facteurs de risque et en évaluant leur effet à moyen et à long terme.
Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.
Creators: name: Smithies, O
name: Valancius, V
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: We have introduced a 4-bp insertion into the hypoxanthine phosphoribosyltransferase (HPRT) gene of a mouse embryonic stem (ES) cell line by using an "in-out" targeting procedure. During the in step, a homologous integration reaction, we targeted a correcting plasmid to a partially deleted hprt- locus by using an integrating vector that carried a 4-bp insertion in the region of DNA homologous to the target locus. HPRT+ recombinants were isolated by direct selection in hypoxanthine-aminopterin-thymidine (HAT) medium. The HATr cell lines were then grown in medium containing 6-thioguanine (6-TG) to select for hprt- revertants resulting from the excision of the integrated vector sequences. The revertants were examined by Southern blot hybridization to determine the accuracy of this out reaction and the frequency of retaining the 4-bp modification in the genome. Of the 6-TGr colonies examined, 88% had accurately excised the integrated vector sequences; 19 of 20 accurate revertants retained the 4-bp insertion in the resulting hprt- gene. We suggest a scheme for making the in-out targeting procedure generally useful to modify the mammalian genome.
title: Structural modelling of Agbada (Tertiary) sandstone reservoirs in “Atled Creek”, Onshore Niger Delta, Nigeria
Creators: name:  Adamolekun ,  Olajide Jonathan
name:  Busch ,  Benjamin
name:  Akwaowoh ,  Idongesit
name:  Suess ,  Michael P.
name:  Hilgers ,  Christoph
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The distribution of rocks and rock properties is an important part of an overall strategy for reservoir development, placement of new wells and prediction of future production. It also provides a detailed look into the local development of a sedimentary basin. Here we present a case-study from the “Atled Creek” concession, onshore Nigeria. A 3D structural reservoir model of the concession was prepared from available industry seismic data and well logs. Four sandstone reservoirs within the Cenozoic have been identified in the “Atled Creek” and modelled in this study to highlight variations in the reservoir properties. Four available wells were subjected to conventional well log analyses and reservoir units were mapped on the 3D seismic volume. The resulting facies and property logs were upscaled and together with the interpreted seismic horizons and faults formed the input data for facies and property modelling. This resulted in frameworks of 3D facies, petrophysical and fault models. The fault model revealed the dominance of generally W–E trending faults. A major fault trending WNW –ESE (F1) separates the reservoirs into two major blocks with the existing well located in the southern block. Fault assisted anticlinal closure is likely the prominent trapping mechanism revealed by the structural model. The reservoir model classified the reservoirs as moderate to good with total porosity of 23.8 – 34.7% in reservoir unit A, 6.3 – 33.1% in reservoir unit B,3.1 – 42.8% in reservoir unit C and 6.4 – 41.7% in reservoir unit D.
Comment communiquer avec un patient dans l'incapacité de parler ?
Creators: name: Gottofrey, Annabelle
name: Langer, Rébecca
Publisher: name: Unknown
Year: 0
Subjects: subject: relation soignant-soigné
subject: communication
subject: communication non-verbale
subject: soins intensifs
subject: patient

description: La première approche est celle de questionner la place de l’école du caring, prônant entre autre une prise en charge holistique de la personne dans un milieu où la technologie est très présente. L’enjeu de faire coexister ces concepts pour les infirmières est un enjeu majeur. Suite à divers questionnements sur la place des besoins psychologiques, la relation et à nos différentes lectures, nous avons identifié la récurrence du problème de communication. Nous avons limité notre champ d’étude à des patients intubés, conscients et adultes et centré notre approche sur la communication avec le patient et non les proches.
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
Convergence analysis for gradient flows in the training of artificial neural networks with ReLU activation
Creators: name: Jentzen, Arnulf
name: Riekert, Adrian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Numerical Analysis (math.NA)
subject: Dynamical Systems (math.DS)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Gradient descent (GD) type optimization schemes are the standard methods to train artificial neural networks (ANNs) with rectified linear unit (ReLU) activation. Such schemes can be considered as discretizations of gradient flows (GFs) associated to the training of ANNs with ReLU activation and most of the key difficulties in the mathematical convergence analysis of GD type optimization schemes in the training of ANNs with ReLU activation seem to be already present in the dynamics of the corresponding GF differential equations. It is the key subject of this work to analyze such GF differential equations in the training of ANNs with ReLU activation and three layers (one input layer, one hidden layer, and one output layer). In particular, in this article we prove in the case where the target function is possibly multi-dimensional and continuous and in the case where the probability distribution of the input data is absolutely continuous with respect to the Lebesgue measure that the risk of every bounded GF trajectory converges to the risk of a critical point. In addition, in this article we show in the case of a 1-dimensional affine linear target function and in the case where the probability distribution of the input data coincides with the standard uniform distribution that the risk of every bounded GF trajectory converges to zero if the initial risk is sufficiently small. Finally, in the special situation where there is only one neuron on the hidden layer (1-dimensional hidden layer) we strengthen the above named result for affine linear target functions by proving that that the risk of every (not necessarily bounded) GF trajectory converges to zero if the initial risk is sufficiently small.
description: 37 pages
Enthalpy and high temperature relaxation kinetics of stable vapor-deposited glasses of toluene
Creators: name: Bhattacharya, Deepanjan
name: Sadtchenko, Vlad
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Stable non-crystalline toluene films of micrometer and nanometer thicknesses were grown by vapor deposition at distinct rates and probed by Fast Scanning Calorimetry. Fast scanning calorimetry is shown to be extremely sensitive to the structure of the vapor-deposited phase and was used to characterize simultaneously its kinetic stability and its thermodynamic properties. According to our analysis, transformation of vapor -deposited samples of toluene during heating with rates in excess 10^5 K/s follows the zero-order kinetics. The transformation rate correlates strongly with the initial enthalpy of the sample, which increases with the deposition rate according to sub-linear law. Analysis of the transformation kinetics of vapor deposited toluene films of various thicknesses reveal a sudden increase in the transformation rate for films thinner than 250 nm. The change in kinetics correlates with the surface roughness scale of the substrate, which is interpreted as evidence for kinetic anisotropy of the samples. The implications of these findings for the formation mechanism and structure of vapor deposited stable glasses are discussed.
description: 22 pages, 14 figures
Survey ACE framework English and Portuguese
Creators: name: Spricigo, Cinthia Bittencourt
name: Camilotti, Bárbara Maria
name: Graham, Charles R.
name: Baptista, Rute
Publisher: name: Zenodo
Year: 2022

description: Survey applied to BUNIV students from online Undergraduation Programms - Overall Engagement Indicators and Facilitators/Barriers for academic engagement (ACE framework).
Supplementary Tables_Moon.pdf
Creators: name: Moon, Jae Hoon
Publisher: name: figshare
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplementary Tables from the manuscript entitled "Effect of initial treatment choice on 2-year quality of life in patients with low-risk papillary thyroid microcarcinoma"
Brownian motion of massive skyrmions forced by spin polarized currents
Creators: name: Troncoso, Roberto E.
name: Núñez, Alvaro S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on the thermal effects on the motion of current-driven massive magnetic skyrmions. The reduced equation for the motion of skyrmion has the form of a stochastic generalized Thiele's equation. We propose an ansatz for the magnetization texture of a non-rigid single skyrmion that depends linearly with the velocity. By utilizing this ansatz it is is found that the mass of skyrmion is closely related to intrinsic skyrmion parameters, such as Gilbert damping, skyrmion-charge and dissipative force. We have found an exact expression for the average drift velocity as well as the mean-square velocity of the skyrmion. The longitudinal and transverse mobility of skyrmions for small spin-velocity of electrons is also determined and found to be independent of the skyrmion mass.
Activation of the HLA-DRA gene in primary human T lymphocytes: novel usage of TATA and the X and Y promoter elements.
Creators: name: Ting, J P
name: Matsushima, G K
name: Itoh-Lindstrom, Y
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Human T lymphocytes express human leukocyte antigen (HLA)-DR-alpha (DRA) upon mitogenic or antigenic stimulation. DR+ T cells are also found in a number of inflammatory and autoimmune diseases and have a proposed role in these diseases. The molecular mechanism of DR regulation in untransformed blood T lymphocytes was studied here by transient transfection of DRA-chloramphenicol acetyltransferase reporter gene constructs. Several novel features of this regulation were observed. During the early stages of T-cell activation by mitogens or antigens, strong promoter induction was exhibited with the proximal 43 bp of the DRA promoter which contains a TATTA motif. Addition of upstream X and Y DNA elements augmented the response. This contrasts with data from transformed cell lines in which the proximal 43 bp produced no detectable promoter function, and the inclusion of X and Y elements is essential for basal level expression. Mutation of the TATTA motif or substitution with a functional but different TATA element produced errant initiation and greatly reduced gene expression. Interestingly, T lymphocytes from a normal donor were DR+ prior to in vitro stimulation, and again, strong promoter activity was observed with 43 bp of proximal sequence. Unexpectedly, the presence of the X and Y elements correlated with a suppression of class II promoter function and surface antigen expression. This study of nontransformed lymphocytes reveals several novel features of DRA gene regulation and underscores the value and necessity of such studies.
Prévenir la violence en psychiatrie tout en considérant son "élan de vie" dans la relation
Creators: name: Falcy, Enora
name: Gsteiger, Maude
Publisher: name: Unknown
Year: 0
Subjects: subject: prévention
subject: violence
subject: psychiatrie
subject: santé mentale
subject: relation soignant-soigné

description: La problématique concerne la violence en milieu psychiatrique. Nous la considérons comme un processus qui augmente ou diminue selon le vécu du patient. Dans les soins en psychiatrie adulte, elle prend place dans l’interaction sociale entre le soignant et le patient. Elle peut être la manifestation d’un processus positif (élan de vie). Deux concepts sont développés, il s’agit de la violence en tant que processus et de la prévention (primaire et secondaire).
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
Fractional Dynamical Model for the Generation of ECG like Signals from Filtered Coupled Van-der Pol Oscillators
Creators: name: Das, Saptarshi
name: Maharatna, Koushik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Medical Physics (physics.med-ph)
subject: Classical Analysis and ODEs (math.CA)
subject: Dynamical Systems (math.DS)
subject: Chaotic Dynamics (nlin.CD)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper, an incommensurate fractional order (FO) model has been proposed to generate ECG like waveforms. Earlier investigation of ECG like waveform generation is based on two identical Van-der Pol (VdP) family of oscillators which are coupled by time delays and gains. In this paper, we suitably modify the three state equations corresponding to the nonlinear cross-product of states, time delay coupling of the two oscillators and low-pass filtering, using the concept of fractional derivatives. Our results show that a wide variety of ECG like waveforms can be simulated from the proposed generalized models, characterizing heart conditions under different physiological conditions. Such generalization of the modelling of ECG waveforms may be useful to understand the physiological process behind ECG signal generation in normal and abnormal heart conditions. Along with the proposed FO models, an optimization based approach is also presented to estimate the VdP oscillator parameters for representing a realistic ECG like signal.
description: 28 pages, 12 figures
Accompagnement infirmier dans la prise en charge des femmes qui envisagent une mastectomie prophylactique bilatérale
Creators: name: Deschamps, Arthur
name: Dias, Vanessa
name: Pereira, Sabine
Publisher: name: Unknown
Year: 0
Subjects: subject: rôle infirmier
subject: pévention
subject: risque
subject: cancer
subject: sein
subject: mastectomie

description: Cette revue de la littérature traite de l’accompagnement infirmier dans la prise en charge des femmes envisageant une mastectomie prophylactique bilatérale pour éradiquer leur risque de cancer du sein. Notre problématique s’insère dans le contexte des soins aux jeunes femmes en bonne santé mais à haut risque familial de cancer, confrontées à la décision d’effectuer ou non un test génétique puis au dilemme entre une surveillance classique par imagerie versus une mastectomie bilatérale prophylactique suivie d’une reconstruction mammaire. Elle s’intègre dans un contexte de soins encore peu développés en Suisse en tant que tels. Ce travail est centré sur les dimensions psychoaffectives qu’engendre une telle prise de décision. Nous avons confronté cette problématique à la littérature scientifique selon une méthodologie rigoureuse, ce qui nous a permis d’apporter des prémisses de réponses et des pistes d’interventions.
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
A MATLAB Toolbox for Hybrid Rigid Soft Robots Based on the Geometric Variable Strain Approach
Creators: name: Mathew, Anup Teejo
name: Hmida, Ikhlas Ben
name: Armanini, Costanza
name: Boyer, Frederic
name: Renda, Federico
Publisher: name: arXiv
Year: 2021
Subjects: subject: Robotics (cs.RO)
subject: Applied Physics (physics.app-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Soft robotics has been a trending topic within the robotics community for almost two decades. However, available tools for the modeling and analysis of soft robots are still limited. This paper introduces a user-friendly MATLAB toolbox, Soft Robot Simulator (SoRoSim), that integrates the Geometric Variable Strain (GVS) model of Cosserat rods to facilitate the static and dynamic analysis of soft, rigid, or hybrid robotic systems. We present a brief overview of the design and structure of the toolbox and validate it by comparing its results with those published in the literature. To highlight the toolbox's potential to efficiently model, simulate, optimize, and control various robotic systems, we demonstrate four sample applications. The demonstrated applications explore different actuator and external loading conditions of single-, branched-, open-, and closed-chain robotic systems. We think that the soft-robotics research community will significantly benefit from the SoRoSim toolbox for a wide variety of applications.
description: 17 pages including reference, 11 figures and 2 tables
Semi-dileptonic decays of the light vector mesons in Light Front Quark Model
Creators: name: Geng, Chao-Qiang
name: Lih, Chong-Chung
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study the transition form factors of the light vector to pseudoscalar mesons as functions of the momentum transfer $q^2$ within the light-front quark model. With these form factors, we calculate the decay branching ratios of all possible modes for $V\to P\ell^+\ell^-$ ($V=ω$ and $ϕ$, $P=π^0$, $η$ and $η^{\prime}$ and $\ell=e$ and $μ$). We find that our numerical results fit with the data, such as those of $ω\to π^0 \ell^+\ell^-$ and $ϕ\to π^0 e^+e^-$ by NA60 and $ϕ\toηe^+e^-$ by SND. We also predict that the branching ratios of $ϕ\to π^0 μ^+μ^-$, $ω\to ηe^+e^-$, $ω\to ημ^+μ^-$, $ϕ\to ημ^+μ^-$ and $ϕ\to η^{\prime} e^+e^-$ to be aroud $3.48\times 10^{-6}$, $3.22\times 10^{-6}$, $1.81\times 10^{-9}$, $6.86\times 10^{-6}$ $2.97\times 10^{-7}$, respectively.
description: 13 pages, 6 figures, References updated
Characterization of two developmentally regulated sea urchin U2 small nuclear RNA promoters: a common required TATA sequence and independent proximal and distal elements.
Creators: name: Marzluff, W F
name: Stefanovic, B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The promoters of two U2 small nuclear RNA genes isolated from the sea urchin Lytechinus variegatus were mapped by microinjection of genes into sea urchin zygotes. One gene, LvU2E, is expressed only in oocytes and embryos and is found in a tandemly repeated gene set, while the other gene, LvU2L, is a single-copy gene and is expressed in embryos and somatic cells. The promoters each contain a TATA sequence at -25 which is required for expression, a proximal sequence element (PSE) centered at -55 required for expression, a sequence at -100 which couples the core promoter (PSE plus TATA box) to the upstream element, and an upstream sequence which stimulates expression fourfold. The PSE together with the TATA sequence is sufficient to determine the transcription start site. There is no sequence similarity between the -100 and PSE sequences of the two genes. The -100 sequences can be interchanged between the two genes. The LvU2E PSE functions in the context of the LvU2L gene, but the LvU2L PSE functions poorly in the context of the LvU2E gene.
Machine Learned Interatomic Potential for Dispersion Strengthened Plasma Facing Components
Creators: name: Sikorski, E. L.
name: Cusentino, M. A.
name: McCarthy, M. J.
name: Tranchida, J.
name: Wood, M. A.
name: Thompson, A. P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Tungsten (W) is a material of choice for the divertor material due to its high melting temperature, thermal conductivity, and sputtering threshold. However, W has a very high brittle-to-ductile transition temperature and at fusion reactor temperatures ($\geq$1000K) may undergo recrystallization and grain growth. Dispersion-strengthening W with zirconium carbide (ZrC) can improve ductility and limit grain growth, but much of the effects of the dispersoids on microstructural evolution and thermomechanical properties at high temperature are still unknown. We present a machine learned Spectral Neighbor Analysis Potential (SNAP) for W-ZrC that can now be used to study these materials. In order to construct a potential suitable for large-scale atomistic simulations at fusion reactor temperatures, it is necessary to train on ab initio data generated for a diverse set of structures, chemical environments, and temperatures. Further accuracy and stability tests of the potential were achieved using objective functions for both material properties and high temperature stability. Validation of lattice parameters, surface energies, bulk moduli, and thermal expansion is confirmed on the optimized potential. Tensile tests of W/ZrC bicrystals show that while the W(110)-ZrC(111) C-terminated bicrystal has the highest ultimate tensile strength (UTS) at room temperature, observed strength decreases with increasing temperature. At 2500K, the terminating C layer diffuses into the W, resulting in a weaker W-Zr interface. Meanwhile, the W(110)-ZrC(111) Zr-terminated bicrystal has the highest UTS at 2500K.
title: Soins de prévention auprès des requérants d'asile
title: comment collaborer ?
titleType: Subtitle
Creators: name: Dössegger, Isabelle
name: Isaac, Fanny
Publisher: name: Unknown
Year: 0
Subjects: subject: rôle infirmier
subject: prévention
subject: soins
subject: droits d'asile

description: La situation des requérants d’asile en Suisse, dans un contexte de prévention des maladies, est un sujet actuel qui fait intervenir la dimension socio-culturelle en quête de repères, et les dimensions biologique et psychologique souvent perturbées. Nous savons que cette population estime être moins bien soignée que les autochtones, que leur accès aux soins est difficile. De plus, une situation de précarité comme la leur, peut les inciter à prioriser leurs besoins physiologiques et sécuritaires, selon la pyramide de Maslow (Annexe 5), ce qui pourrait défavoriser les soins de prévention. Ainsi prend sens le désir de collaborer avec cette population dans un but de soins de prévention.
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
Thermodynamics of N-dimensional quantum walks
Creators: name: Romanelli, Alejandro
name: Donangelo, Raul
name: Portugal, Renato
name: Marquezino, Franklin L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The entanglement between the position and coin state of a $N$-dimensional quantum walker is shown to lead to a thermodynamic theory. The entropy, in this thermodynamics, is associated to the reduced density operator for the evolution of chirality, taking a partial trace over positions. From the asymptotic reduced density matrix it is possible to define thermodynamic quantities, such as the asymptotic entanglement entropy, temperature, Helmholz free energy, etc. We study in detail the case of a $2$-dimensional quantum walk, in the case of two different initial conditions: a non-separable coin-position initial state, and a separable one. The resulting entanglement temperature is presented as function of the parameters of the system and those of the initial conditions.
description: 10 pages, 4 figs
Clustering-Based Representation Learning through Output Translation and Its Application to Remote--Sensing Images
Creators: name: Li, Qinglin
name: Li, Bin
name: Garibaldi, Jonathan M
name: Qiu, Guoping
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In supervised deep learning, learning good representations for remote--sensing images (RSI) relies on manual annotations. However, in the area of remote sensing, it is hard to obtain huge amounts of labeled data. Recently, self--supervised learning shows its outstanding capability to learn representations of images, especially the methods of instance discrimination. Comparing methods of instance discrimination, clustering--based methods not only view the transformations of the same image as ``positive" samples but also similar images. In this paper, we propose a new clustering-based method for representation learning. We first introduce a quantity to measure representations' discriminativeness and from which we show that even distribution requires the most discriminative representations. This provides a theoretical insight into why evenly distributing the images works well. We notice that only the even distributions that preserve representations' neighborhood relations are desirable. Therefore, we develop an algorithm that translates the outputs of a neural network to achieve the goal of evenly distributing the samples while preserving outputs' neighborhood relations. Extensive experiments have demonstrated that our method can learn representations that are as good as or better than the state of the art approaches, and that our method performs computationally efficiently and robustly on various RSI datasets.
description: 14 pages
E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.
Creators: name: Wade, M
name: Kowalik, T F
name: Huang, E S
name: Azizkhan, J C
name: Mudryj, M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The adenovirus immediate-early protein E1A activates the adenovirus E2 promoter and several cellular gene promoters through transcription factor E2F. The immediate-early proteins of human cytomegalovirus (HCMV) can complement an E1A-deficient adenovirus mutant and activate the adenovirus E2 promoter. HCMV also has been shown to activate the adenovirus E2 promoter. On the basis of these findings, we have investigated whether HCMV can activate the promoter of the cellular dihydrofolate reductase (DHFR) gene, which requires E2F binding for maximal promoter activity. We show that HCMV activates the DHFR promoter and that products of the HCMV major immediate-early gene region mediate the activation of the promoter specifically through the E2F site. We used gel mobility shift assays to search for potential molecular mechanisms for this activation and found an "infection-specific" multimeric complex that bound to the E2F sites in the DHFR and E2 promoters in extracts from HCMV-infected cells but not in extracts from uninfected cells. Several antibodies against HCMV immediate-early gene products had no effect on this infection-specific complex. Subsequently, the complex was found to contain E2F, cyclin A, p33cdk2, and p107 and to be similar to S-phase-specific complexes that recently have been identified in several cell types. A functional role for the binding of the cyclin A-p33cdk2 complex to cellular gene promoters has yet to be demonstrated; however, HCMV infection causes the induction of both cellular DNA replication and transcription of growth-related genes containing E2F sites in their promoters. The findings described above therefore may relate to both of these effects of HCMV infection. We also provide evidence that some of the molecular events associated with adenovirus infection are different from those associated with HCMV infection.
MESS: Manifold Embedding Motivated Super Sampling
Creators: name: Thordsen, Erik
name: Schubert, Erich
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Many approaches in the field of machine learning and data analysis rely on the assumption that the observed data lies on lower-dimensional manifolds. This assumption has been verified empirically for many real data sets. To make use of this manifold assumption one generally requires the manifold to be locally sampled to a certain density such that features of the manifold can be observed. However, for increasing intrinsic dimensionality of a data set the required data density introduces the need for very large data sets, resulting in one of the many faces of the curse of dimensionality. To combat the increased requirement for local data density we propose a framework to generate virtual data points that faithful to an approximate embedding function underlying the manifold observable in the data.
Polaron with Quadratic Electron-phonon Interaction
Creators: name: Ragni, Stefano
name: Hahn, Thomas
name: Zhang, Zhongjin
name: Prokof'ev, Nikolay
name: Kuklov, Anatoly
name: Klimin, Serghei
name: Houtput, Matthew
name: Svistunov, Boris
name: Tempere, Jacques
name: Nagaosa, Naoto
name: Franchini, Cesare
name: Mishchenko, Andrey S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present the first numerically exact study of a polaron with quadratic coupling to the oscillator displacement, using two alternative methodological developments. Our results cover both anti-adiabatic and adiabatic regimes and the entire range of electron-phonon coupling $g_2$, from the system's stability threshold at attractive $g_2=-1$ to arbitrary strong repulsion at $g_2 \gg 1$. Key properties of quadratic polarons prove dramatically different from their linear counterparts. They (i) are insensitive even to large quadratic coupling except in the anti-adiabatic limit near the threshold of instability at attraction; (ii) depend only on the adiabatic ratio but are insensitive to the electron dispersion and dimension of space; (iii) feature weak lattice deformations even at the instability point. Our results are of direct relevance to properties of electrons at low densities in polar materials, including recent proposals for their superconducting states.
description: 6 pages, 6 figures + supplemental material
Large zero bias peaks and dips in a four-terminal thin InAs-Al nanowire device
Creators: name: Song, Huading
name: Zhang, Zitong
name: Pan, Dong
name: Liu, Donghao
name: Wang, Zhaoyu
name: Cao, Zhan
name: Liu, Lei
name: Wen, Lianjun
name: Liao, Dunyuan
name: Zhuo, Ran
name: Liu, Dong E
name: Shang, Runan
name: Zhao, Jianhua
name: Zhang, Hao
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report electron transport studies of a thin InAs-Al hybrid semiconductor-superconductor nanowire device using a four-terminal design. Compared to previous works, thinner InAs nanowire (diameter less than 40 nm) is expected to reach fewer sub-band regime. The four-terminal device design excludes electrode contact resistance, an unknown value which has inevitably affected previously reported device conductance. Using tunneling spectroscopy, we find large zero-bias peaks (ZBPs) in differential conductance on the order of $2e^2/h$. Investigating the ZBP evolution by sweeping various gate voltages and magnetic field, we find a transition between a zero-bias peak and a zero-bias dip while the zero-bias conductance sticks close to $2e^2/h$. We discuss a topologically trivial interpretation involving disorder, smooth potential variation and quasi-Majorana zero modes.
description: Raw data and processing codes are available at http://doi.org/10.5281/zenodo.5111639
Isometries and Hermitian Operators on Zygmund spaces
Creators: name: Botelho, Fernanda
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46E15, 47B15, 47B38

description: In this paper we characterize the isometries of subspaces of the little Zygmund space. We show that the isometries of these spaces are surjective and represented as integral operators. We also show that all hermitian operators on these settings are bounded.
PyQMC: an all-Python real-space quantum Monte Carlo module in PySCF
Creators: name: Wheeler, William A.
name: Pathak, Shivesh
name: Kleiner, Kevin
name: Yuan, Shunyue
name: Rodrigues, João N. B.
name: Lorsung, Cooper
name: Krongchon, Kittithat
name: Chang, Yueqing
name: Zhou, Yiqing
name: Busemeyer, Brian
name: Williams, Kiel T.
name: Muñoz, Alexander
name: Chow, Chun Yu
name: Wagner, Lucas K.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We describe a new open-source Python-based package for high accuracy correlated electron calculations using quantum Monte Carlo (QMC) in real space: PyQMC. PyQMC implements modern versions of QMC algorithms in an accessible format, enabling algorithmic development and easy implementation of complex workflows. Tight integration with the PySCF environment allows for simple comparison between QMC calculations and other many-body wave function techniques, as well as access to high accuracy trial wave functions.
Formation of the 3' end of sea urchin U1 small nuclear RNA occurs independently of the conserved 3' box and on transcripts initiated from a histone promoter.
Creators: name: Wendelburg, B J
name: Marzluff, W F
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The formation of the 3' end of vertebrate small nuclear RNAs (snRNAs) requires that transcription initiate from an snRNA promoter. There is a loosely conserved required box 5 to 20 nucleotides (nt) 3' of the gene. The sea urchin snRNA genes contain promoter elements different from those of the vertebrate snRNAs. They also contain a characteristic 3' 15-nt sequence which is conserved among different sea urchin snRNA genes. We used microinjection of sea urchin U1 snRNA genes into sea urchin zygotes to define the sequence requirements for U1 snRNA 3'-end formation. Surprisingly, the conserved 3' box is not required for efficient 3'-end formation in vivo. Deletion analysis reveals that the 6 nt immediately 3' of the U1 snRNA are involved in 3'-end formation. Substitution analysis revealed that either these 6 nt 3' of the U1 RNA or the conserved 3' box could direct 3'-end formation. Transcripts initiated from a histone H4 promoter formed U1 3' ends about 50% as efficiently as transcripts initiated from the U1 promoter, even when the U1 end was placed in tandem with a histone 3'-processing signal, suggesting that transcription from an snRNA promoter is not necessary for formation of the 3' end of sea urchin U1 snRNA.
Stratégies de communication et attitude infirmière auprès d’enfants autistes
Creators: name: Asani, Canije
name: McGimpsey, Evelien
Publisher: name: Unknown
Year: 0
Subjects: subject: rôle infirmier
subject: stratégie
subject: communication
subject: enfant
subject: autisme
subject: relation soignant-soigné

description: Le contexte de notre revue de littérature se situe principalement au sein d’un centre hospitalier pédiatrique. La population touchée par notre questionnement comprend les infirmières, les parents et principalement les enfants d’âge pré-scolaire jusqu’à 15 ans atteints d’un trouble du spectre autistique.
description: Mémoire de bachelor : Haute Ecole de la Santé La Source, 2012
A groupoid approach to interacting fermions
Creators: name: Mesland, Bram
name: Prodan, Emil
Publisher: name: arXiv
Year: 2021
Subjects: subject: Operator Algebras (math.OA)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider the algebra $\dotΣ(\mathcal L)$ generated by the inner-limit derivations over the ${\rm GICAR}$ algebra of a fermion gas populating an aperiodic Delone set $\mathcal L$. Under standard physical assumptions such as finite interaction range, Galilean invariance and continuity with respect to the aperiodic lattice, we demonstrate that the image of $\dot Σ(\mathcal L)$ through the Fock representation can be completed to a groupoid-solvable pro-$C^\ast$-algebra. Our result is the first step towards unlocking the $K$-theoretic tools available for separable $C^\ast$-algebra for applications in the context of interacting fermions.
A short introduction to translation surfaces, Veech surfaces, and Teichmueller dynamics
Creators: name: Massart, Daniel
Publisher: name: arXiv
Year: 2021
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37D40, 30F60, 32G15

description: We review the different notions about translation surfaces which are necessary to understand McMullen's classification of $GL_2^+(\mathbb{R})$-orbit closures in genus two. In Section 2 we recall the different definitions of a translation surface, in increasing order of abstraction, starting with cutting and pasting plane polygons, ending with Abelian differentials. In Section 3 we define the moduli space of translation surfaces and explain its stratification by the type of zeroes of the Abelian differential, the local coordinates given by the relative periods, its relationship with the moduli space of complex structures and the Teichműller geodesic flow. In Part II we introduce the $GL_2^+(\mathbb{R})$-action, and define the related notions of Veech group, Teichműller disk, and Veech surface. In Section 9 we explain how McMullen classifies $GL_2^+(\mathbb{R})$-orbit closures in genus $2$: you have orbit closures of dimension $1$ (Veech surfaces, of which a complete list is given), $2$ (Hilbert modular surfaces, of which again a complete list is given), and $3$ (the whole moduli space of complex structures). In the last section we review some recent progress in higher genus.
description: The final version of this paper will appear in the book: Surveys in Geometry I, ed. A. Papadopoulos, Springer Nature, 2021
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner
Creators: name: Whitehead, CA
name: Fang, H
name: Su, H
name: Morokoff, AP
name: Kaye, AH
name: Hanssen, E
name: Nowell, CJ
name: Drummond, KJ
name: Greening, David
name: Vella, LJ
name: Mantamadiotis, T
name: Stylli, SS
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Purpose: The therapeutic efficacy of radiotherapy/temozolomide treatment for glioblastoma (GBM) is limited by the augmented invasiveness mediated by invadopodia activity of surviving GBM cells. As yet, however the underlying mechanisms remain poorly understood. Due to their ability to transport oncogenic material between cells, small extracellular vesicles (sEVs) have emerged as key mediators of tumour progression. We hypothesize that the sustained growth and invasion of cancer cells depends on bidirectional sEV-mediated cell–cell communication. Methods: Invadopodia assays and zymography gels were used to examine the invadopodia activity capacity of GBM cells. Differential ultracentrifugation was utilized to isolate sEVs from conditioned medium and proteomic analyses were conducted on both GBM cell lines and their sEVs to determine the cargo present within the sEVs. In addition, the impact of radiotherapy and temozolomide treatment of GBM cells was studied. Results: We found that GBM cells form active invadopodia and secrete sEVs containing the matrix metalloproteinase MMP-2. Subsequent proteomic studies revealed the presence of an invadopodia-related protein sEV cargo and that sEVs from highly invadopodia active GBM cells (LN229) increase invadopodia activity in sEV recipient GBM cells. We also found that GBM cells displayed increases in invadopodia activity and sEV secretion post radiation/temozolomide treatment. Together, these data reveal a relationship between invadopodia and sEV composition/secretion/uptake in promoting the invasiveness of GBM cells. Conclusions: Our data indicate that sEVs secreted by GBM cells can facilitate tumour invasion by promoting invadopodia activity in recipient cells, which may be enhanced by treatment with radio-chemotherapy. The transfer of pro-invasive cargos may yield important insights into the functional capacity of sEVs in invadopodia.
Uniqueness and Nonuniqueness in Inverse Hyperbolic Problems and The Black Hole Phenomenon
Creators: name: Eskin, Gregory
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: This paper consists of two parts. In the first part we describe the recent works on the inverse problems for the wave equation in $(n+1)$-dimensional space equipped with pseudo-Riemannian metric with Lorentz signature. We study the conditions of the existence of black (or white) holes for these wave equations. In the second part we prove energy type estimates on a finite time interval in the presence of black or white holes. We use these estimates to prove the nonuniqueness of the inverse problems.
Tuning Superconductivity and Charge Density Wave Order in 2H-TaSe2 by Modulating the Van Hove Singularity
Creators: name: Adam, Mukhtar Lawan
name: Garba, Ibrahim Buba
name: Bala, Abba Alhaji
name: Suleiman, Abdulsalam Aji
name: Gana, Sulaiman Muhammad
name: Adam, Faisal Lawan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Tantalum diselenide (TaSe2) is an exciting material that hosts charge density wave order (CDW) and superconductivity. Thus, providing a playing field for examining the interactions of fundamental electronic quantum states in materials. Recent research has proposed that the intrinsic quantum electronic state in the TaSe2 lattice could be improved by aligning the Van Hove singularity (VHs) with the Fermi level. In this study, we attempt to tune the VHs in TaSe2 to align them within the vicinity of the Fermi level via electron doping by chemically substituting Pt for Ta atoms. On investigating the band structure of Pt0.2Ta0.8Se2, the electron doping brought the VHs closer to the Fermi level vicinity around the K high symmetry point. As a result, the CDW state in pristine TaSe2 is suppressed in the TaSe2 doped system while also hosting an enhanced superconducting temperature (Tc) of ~2.7 K. These observations provide insight into ways to leverage the VHs in materials to tune their electronic properties.
description: 14 pages, 4 figures
Measurements of excision repair tracts formed during meiotic recombination in Saccharomyces cerevisiae.
Creators: name: Detloff, P
name: Petes, T D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: During meiotic recombination in the yeast Saccharomyces cerevisiae, heteroduplexes are formed at a high frequency between HIS4 genes located on homologous chromosomes. Using mutant alleles of the HIS4 gene that result in poorly repaired mismatches in heteroduplex DNA, we find that heteroduplexes often span a distance of 1.8 kb. In addition, we show that about one-third of the repair tracts initiated at well-repaired mismatches extend 900 bp.
Silica aerogel radiator for use in the A-RICH system utilized in the Belle II experiment
Creators: name: Tabata, Makoto
name: Adachi, Ichiro
name: Hamada, Nao
name: Hara, Koji
name: Iijima, Toru
name: Iwata, Shuichi
name: Kakuno, Hidekazu
name: Kawai, Hideyuki
name: Korpar, Samo
name: Križan, Peter
name: Kumita, Tetsuro
name: Nishida, Shohei
name: Ogawa, Satoru
name: Pestotnik, Rok
name: Šantelj, Luka
name: Seljak, Andrej
name: Sumiyoshi, Takayuki
name: Tahirović, Elvedin
name: Yoshida, Keisuke
name: Yusa, Yosuke
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: This paper presents recent progress in the development and mass production of large-area hydrophobic silica aerogels for use as radiators in the aerogel-based ring-imaging Cherenkov (A-RICH) counter, which will be installed in the forward end cap of the Belle II detector. The proximity-focusing A-RICH system is especially designed to identify charged kaons and pions. The refractive index of the installed aerogel Cherenkov radiators is approximately 1.05, and we aim for a separation capability exceeding 4$σ$ at momenta up to 4 GeV/$c$. Large-area aerogel tiles (over 18 $\times $ 18 $\times $ 2 cm$^3$) were first fabricated in test productions by pin drying in addition to conventional methods. We proposed to fill the large end-cap region (area 3.5 m$^2$) with 124 water-jet-trimmed fan-shaped dual-layer-focusing aerogel combinations of different refractive indices (1.045 and 1.055). Guided by the test production results, we decided to manufacture aerogels by the conventional method and are currently proceeding with mass production. In an electron beam test undertaken at the DESY, we confirmed that the $K$/$π$ separation capability of a prototype A-RICH counter exceeded 4$σ$ at 4 GeV/$c$.
description: To be published in Nucl. Instrum. Methods A,, 5 pages, 5 figures
Rigorous Bounds on Light-by-Light Scattering
Creators: name: Henriksson, Johan
name: McPeak, Brian
name: Russo, Francesco
name: Vichi, Alessandro
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We bound EFT coefficients appearing in $2 \to 2$ photon scattering amplitudes in four dimensions. After reviewing unitarity and positivity conditions in this context, we use dispersion relations and crossing symmetry to compute sum rules and null constraints. This allows us to derive new rigorous bounds on operators with four, six, and eight derivatives, including two-sided bounds on their ratios. Comparing with a number of partial UV completions, we find that some of our bounds are saturated by the amplitudes that arise from integrating out a massive scalar or axion, while others suggest the existence of unknown amplitudes.
description: 39 pages, 6 figures