cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Roles of miR-126/Egfl7 During Lung Cancer Angiogenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The role of blood vessels in facilitating lung cancer growth is well recognized, and the blockade of lung cancer angiogenesis is currently utilized in patients as a therapeutic strategy. The current proposal investigates the novel endothelial-expressed miR-126/Egfl7 locus and its contribution to lung cancer angiogenesis and progression. MiR-126 is an intriguing microRNA which is located within intron 7 of a host gene, Egfl7, encoding an EGF-repeat secreted protein. Notably, miR-126/Egfl7 is expressed from a common transcript which is highly upregulated in lung tumor blood vessels as opposed to normal lung vasculature. We have created knockout mice for miR-126 and Egfl7 which have demonstrated that deletion of miR-126 results in compromised blood vessel growth in the embryo. Thus, a major goal of the current proposal is to use miR-126 or Egfl7 knockout mice to test the contribution of this locus to lung cancer angiogenesis and progression using rigorous genetic approaches and a well-validated KRasG12D; p53flox/flox mouse model of lung cancer. Additional components of this proposal include exploration of the molecular basis for miR-126/Egfl7 expression in tumor vasculature, and the demonstration of locus overexpression in human lung cancer specimens. Overall, this application explores a highly novel endothelial microRNA, miR-126, and will obtain proof-of-principle data linking it to lung cancer angiogenesis and progression and identifying it as an anti-angiogenic drug target. Analogous studies will be performed for the poorly understood host gene, Egfl7. These studies should contribute to our knowledge of lung cancer etiology and prevention, as well as identify miR-126/Egfl7 as a novel marker for human lung cancer angiogenesis.
Regulation of biased PAR1 signaling by ubiquitination
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking causes cardiovascular disease which is a leading cause of death in the United States with more than 61 million Americans suffering from some form of cardiovascular disease. The total costs for health care for people with health problems related to smoking is extraordinary in the tens of billions of dollars according to health economists at the University of California. Smoking generates toxins, which enter the blood stream and directly contribute to the development of cardiovascular disease. Toxins are generally thought to damage endothelial cells, which are cells that line the blood vessels. A substantial literature supports the notion that smoke-induced endothelial cell dysfunction is an early event that contributes to more long-term effects on the cardiovascular system. Endothelial cell dysfunction promotes thrombosis (blood clots), which is a critical event in myocardial infarction (heart attacks) and stroke.

 The key initiator of thrombosis is a protease called thrombin. Thrombin activates endothelial cells, promotes inflammatory responses and disrupts endothelial cell barrier integrity, all of these events are hallmarks of endothelial cell dysfunction a pathological condition associated with smoking. However, in non-pathological conditions, the vascular endothelium performs critical functions important for shutting down thrombin activity and protecting against thrombosis. One molecule principally responsible for decreasing thrombin generation and promoting endothelial barrier protection is called activated protein C (APC). Remarkably, however, both thrombin and APC signal through the same cell surface receptor known as protease-activated receptor-1 (PAR1) to elicit opposing functions on endothelial barrier integrity. How two different proteins, thrombin and APC, act through the same receptor to cause opposite effects in endothelial cells is not known. The focus of this proposal is to understand at the molecular level how PAR1 can differentially regulate endothelial cellular responses. An understanding of the mechanisms by which thrombin and APC promote distinct endothelial cellular responses will enable us to develop new strategies to manipulate receptor signaling and will provide novel targets for the development of new drugs that can be use in the prevention and treatment of vascular endothelial cell dysfunction, a pathological condition induced by smoking.
Subsidiary staffing and performance: the case of foreign multinationals in the U.S.
Creators: name: Colakoglu, Saba
Publisher: name: No Publisher Supplied
Year: 2007

description: International staffing is an important mechanism for the control and coordination of culturally and geographically dispersed operations of a multinational corporation.  However literature on subsidiary staffing patterns and the search for the antecedents of subsidiary staffing has led to mixed results in the past.  Moreover, the relation between subsidiary staffing and subsidiary performance has received very limited attention from researchers.  Thus, this thesis is aimed at improving our understanding of the antecedents and outcomes of subsidiary staffing by addressing two research questions.  My first research question relates to the antecedents of subsidiary staffing.  I explore the influence of cultural distance between home and host countries, uncertainty avoidance dimension of the home country's national culture, and dependence of the subsidiary on the headquarters on subsidiary staffing patterns.  My second research question relates to whether there is a relation between how a subsidiary is staffed and how it performs.  Within this question, I explore whether multinational corporations face a paradox when staffing culturally distant subsidiaries.  Although the literature suggests that cultural distance leads to ethnocentric staffing patterns, I argue that this decision will lower subsidiary performance since cultural distance will also diminish the ability of parent country nationals to operate successfully in such an environment.  I test my model on a random sample of 52 foreign multinationals operating in the U.S.  Although U.S. is the top recipient of foreign direct investment in the world, this population has not been studied in published international staffing studies, and thus is a valuable contribution to the emerging literature on this topic. The results provide support for both of the research questions.  All the three antecedents are significant predictors of the ratio of parent country nationals in the workforce.  For the second research question, although there is no direct relation between subsidiary staffing and performance, this relation depends on the cultural distance between the U.S. and the home country.  Ethnocentric staffing diminishes subsidiary performance significantly when cultural distance is high.
Cyrtolabulus van der Vecht 1969
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Cyrtolabulus

description: Genus Cyrtolabulus van der Vecht, 1969
Cyrtolabulus van der Vecht 1969: replacement name for Cyrtolabus van der Vecht, 1963, nec Voss 1925. Type species: Cyrtolabus suavis van der Vecht, 1963, by original designation as type species of Cyrtolabus van der Vecht.
Cyrtolabulus: Girish Kumar et al. 2015a: 50.
Diagnosis. Mandibles stout and elongate, distinctly cross each other. Clypeus wider than long, weakly emarginate apically. Female without subcircular fovea in front of median ocellus (present in Labus). Cephalic foveae absent. Mesosoma more or less flattened dorso-ventrally, distinctly longer than high. Anterior face of pronotum without medial pits or foveae, sometimes with median transverse striae present. Pronotal carina usually present dorsally. Pronotum produced at humeri. Pretegula carina generally absent or weakly developed? Epicnemial carina weakly developed. Notauli absent. Tegula as wide as long or wider, emarginate posteriorly and reaches posterior end of parategula. Metanotum not dentate, precipitous (Fig. 35). Axillary fossa wide. Propodeal dorsum with extensive horizontal portion behind the postscutellum, somewhat narrowed apically, abruptly sloping posteriorly (Fig. 35). Superior carina absent. Propodeal orifice wide dorsally. Submarginal carina produced as lamellar pointed process above valvula. Propodeal valvula free from submarginal carina posteriorly. Metasoma petiolate, T1 punctate, not conspicuously swollen in apical half (Fig. 67). Lateral margins of T1 closely approaching each other ventrally, usually fused. T2 and S2 lamellate apically. SMC2 basally truncate. Mid tibia with one apical spur. Prestigma much shorter than pterostigma. Ƌ: F11 hook like, rounded apically; F10 shorter than previous ones; apical flagellomeres without cavity on inner margin but sometime a shallow groove present on it. Body length usually 10–12 mm.
Distribution. Ethiopian, Oriental and Palaearctic Regions.
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 29, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Acuticephala Torres 1958
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Acuticephala

description: Acuticephala Torres, 1958
Type species. Acuticephala alipuncta Torres, 1958 (Argentina).
Remarks. The genus is known from Argentina (Torres 1958b) and Uruguay (Ruffinelli 1970).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 83, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Acuticephala alipuncta Torres 1958
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Acuticephala
Acuticephala alipuncta

description: Acuticephala alipuncta Torres, 1958
Acuticephala alipuncta Torres 1958b: 22 (type material examined).
Type locality. Entre Rios, Argentina.
Remarks. The species was reported from Entre Rios, Argentina (Torres 1958b) and Uruguay (Ruffinelli 1970). We collected specimens in Chaco, Entre Rios, and Formosa Provinces. The species is associated with the Chaco and Pampas floristic provinces (Sanborn et al. 2011a).
New provincial records. Chaco, Lapachita, 22-XII-1986, M.S. & J.E. Heath Coll. (two males, MSHC); Chaco, Lapachita, 22-XII-1986, M.S. Heath & Al Sanborn Coll. (two males, MSHC); Chaco, Lapachita, 22-XII-1986, Al Sanborn Coll. (one male, AFSC); Chaco, Lapachita, 22-XII-1986, F. Noriega Coll. (one female, MSHC); Formosa, 8 km So. of Tatané, 28-XII-1986, Al Sanborn & F. Noriega Coll. (one female, MSHC).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 83, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Modulation of molecular mobility in sucrose-based amorphous solids detected by phosphorescence of erythrosin B
Creators: name: You, Yumin
Publisher: name: No Publisher Supplied
Year: 2007

description: This project studied the temperature and composition dependence of molecular mobility in amorphous sucrose. Phosphorescence of erythrosin B provided parameters sensitive to localized molecular mobility in the glass and to more global modes of mobility activated at the glass transition and provided evidence of dynamic site heterogeneity in amorphous sucrose solids. In sucrose-based binary matrices, plasticizer (glycerol), salts (NaCl, CaCl2, MgCl2, Na-citrate, Na-acetate, Na-phosphates), maltodextrins (DE 5 to 18), protein (gelatin), and polysaccharides (xanthan and high amylose starch) were selected to investigate how variations in nature and content of each additive influence the molecular mobility as well as dynamic site heterogeneity in amorphous sucrose matrix.  Measurements of phosphorescence intensity, lifetime, and emission energy were made in amorphous sucrose-additive films containing the probe erythrosin B. Results showed the complex effects of additives on the mobility in a hydrogen-bonded sugar matrix. Glycerol exhibited an antiplasticization effect shown as decreased mobility at glycerol/sucrose mole ratio ≤ 0.27 and at temperature ≤ 45° C. On the contrary, all the polymers studied, including gelatin, xanthan and high amylose starch, displayed a ‘plasticization’ effect (increasing mobility) at very low while a rigidification effect (decreasing mobility) at higher concentration without significant change in Tg. Maltodextrins, mixtures of molecules with a variety of molecular weights, increase the mobility in spite of their high Tg. Sodium chloride showed a strong rigidification effect on the sucrose matrix; however, this effect was weakened at mole ratio NaCl/sucrose above 0.5. Other salts showed effects resulting from a compromise between two opposite actions (decreasing mobility due to salt itself and increasing mobility due to absorbed moisture). All above behaviors are difficult to interpret using Tg alone. Molecular mobility appears to be more accurate to evaluate the physical stability of the matrix.  Phosphorescence of erythrosin B was also able to report dynamic site heterogeneity that is an intrinsic property of the amorphous solid state. The heterogeneity was be evaluated by the variation of lifetime and lifetime heterogeneity across the excitation and emission band and the temperature dependence of bandwidth and lifetime heterogeneity. The composition influence on the dynamic site heterogeneity was discussed as well.
Predictive modeling and optimization in hard turning: investigations of effects on cutting tool micro-geometry
Creators: name: Karpat, Yiğit
Publisher: name: No Publisher Supplied
Year: 2007

description: Hard turning, which is turning of hardened parts into finished components, offers distinct advantages to manufacturers. It is favorable in terms of cost because it has the potential to eliminate the grinding process. Complex surfaces can be machined with a single machine. It is an environmentally friendly process because no cutting fluid is used. Its major drawback is rapid tool wear due to high temperatures and high stresses at the tool rake and flank faces. Short tool lives of expensive Polycrystalline Cubic Boron Nitride (PCBN) type of cutting tools hinder the economic advantage of hard turning. This research focuses mainly on the effects of cutting tool micro geometry on hard turning process. The goal is to develop a methodology for the selection of cutting tool micro geometry and machining parameters for hard turning process. To this end, existing analytical and experimental modeling techniques used in modeling of hard turning will be improved and new methodologies will be proposed.In this research, firstly, we have developed a predictive analytical force, stress and thermal model for machining with worn tools by modifying Oxley’s machining theory. The proposed model combines a work material based deformation model with a moving band heat source model and predicts stresses and temperature distributions on the tool for tool wear modeling. Secondly, we have developed a methodology based on slip-line field analysis and experimental observations to identify tool-chip interface friction in order to investigate the influence of various edge preparations on machining performance. The ideal cutting conditions for a given edge preparation is obtained. Thirdly, we have established physics based models by utilizing 2-D and 3-D finite element methods (FEM) to analyze machining with advanced cutting tool micro geometry in order to improve the tool design for better tool life. Experimental investigations have shown that the cutting tools with advanced edge geometries perform better than uniform edge geometries. Lastly, we have introduced a multi-objective optimization methodology to select optimum machining parameters in the presence of conflicting objectives to assist in decision-making for process planning.
DNA Adducts Arising from Tobacco-derived N-nitrosamines
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is the major risk factor for the development of lung cancer in developed countries. Tobacco and its smoke contain a large number of reactive chemicals, which can bind to human genetic material, DNA. In this study, we will focus on examining the biological consequences of the DNA modifications induced by two abundant tobacco-derived N-nitrosamines, which have been shown previously to be carcinogenic to laboratory animals and are considered carcinogenic to humans by the International Agency for Research on Cancer. In particular, we will ask whether the modified DNA blocks the replication of genomic DNA and whether it introduces mistakes during DNA copying process. The results from this study will offer important insights into the mechanisms of carcinogenesis of these abundant cigarette smoke components.
Inheriting the legacy of critique: dreams of freedom and nightmares of despair
Creators: name: Panfilio, Kenneth Michael
Publisher: name: No Publisher Supplied
Year: 2007

description: This dissertation takes as its challenge the attempt to vivify the practice of affirmative political philosophy as we try to take up the redemptive work commanded upon us when we inherit the legacy of critique, which is articulated in this project to suggest that human beings are the source of all valuation in the larger world.  Accepting such a position recognizes that despite the deep abyss of absurdity that painfully emaciates our subjectivity in the world we must also remember, in the words of Albert Camus, that someone “must give the void its colors.᾿Subsequent chapters juxtapose various thinkers whose work is animated to present a dialectical engagement between antonymous forces of progressive dreams for the fulfillment of our shared human freedom (Immanuel Kant and Karl Marx) simultaneously threatened by corresponding nightmares of despair providing ample warning to the pathological catastrophes rampant throughout our modern age (Martin Heidegger and Theodor Adorno). While each philosophical pairing plays out different mediations between dreams of freedom and nightmares of despair, each engagement is appended by a small reprisal, or return to the original theme, discussing what is philosophically at stake in such an exploration between two thinkers against a pressing issue of great social, economic, and political importance.Concluding this dissertation is a meditation on the work of Walter Benjamin and his view of life as a passageway in the circuitous labyrinths of advanced capitalism simultaneously caught between both nightmares of despair and dreams of freedom where we might indeed simply blow away the sands of sleep and rightfully awaken from the slumber of phantasmagoria.
Informing Smoking Interventions for CA University Students
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Recent studies show that many college students smoke cigarettes. The college years form a transition from adolescence to adulthood, and represent a period during which tobacco use and other health behaviors are still being learned. As such, college students engage in considerable experimentation with smoking and other health risk behaviors. Despite this evidence, relatively few studies have investigated college student cigarette smoking and surprisingly few studies have addressed smoking cessation in this population. As such, cigarette smoking prevention and treatment efforts aimed at college students may yield considerable benefits in reducing the health burden of tobacco addiction.

 To address this issue, the long-term objectives of this line of research are: 1) to provide information to aid the design of effective programs to help college students quit smoking; and 2) to design and evaluate the effectiveness of smoking cessation interventions for college students.

 Few previous studies have examined smoking cessation among college students. To address this gap in knowledge and build upon previous work by our research group, this study will investigate 400 college student smokers to identify key influences on quitting smoking.

 The primary aims of the proposed study are to 1) Identify factors that predict which college students will attempt to quit smoking 2) Identify factors that predict how long students remain abstinent after attempting to quit smoking, and 3) Investigate how alcohol use influences college student efforts to quit smoking.

 The proposed study will recruit and follow 400 18-24 year old undergraduate college students who smoke. Over the course of six months of participation, each student will complete three in-person interviews (baseline, 3- and 6-months), fill-in 18 weekly online calendars to record cigarette and alcohol use, and respond to four monthly online surveys that evaluate attempts to quit smoking (months 1, 2, 4 and 5). Information gathered during the proposed study will be used to design treatments to help college students quit smoking.
A groundwater-surface water partition for the contiguous United States and select case studies
Creators: name: Schaller, Morgan F.
Publisher: name: No Publisher Supplied
Year: 2007

description: The terrestrial water cycle is a highly effective, yet incompletely understood agent for the distribution of continental energy, and hence, the continental energy and water budgets are closely linked.  The spatial organization and temporal memory of the groundwater reservoir, and its interaction with the surface water has an integral role in the lateral transport of water and energy, affecting soil moisture distributions, evapotranspiration, precipitation and stream discharge across the continent.  The current climate models are unable to account for this lateral component, and consequentially are inadequate at predicting future hydrologic conditions; hence, a separation of groundwater flow from surface water flow is necessary to asses the relative importance of each reservoir across the land surface.  Here we present the results of such a groundwater-surface water partition, where 39 years of surface recharge, derived from VIC simulation, are separated from USGS HCDN annual mean observed (naturalized) stream discharge from 1555 basins across the continental U.S.  It was found that stream discharge (Qr) may account for 2% to 891% of the total surface recharge (R) across the 1555 basins, suggesting that individual drainage basins export or import significant amounts of water to or from the groundwater reservoir (e.g., a Qr/R value of 2 (200%) for a basin indicates that half the river discharge from that basin is derived from groundwater input from other basins).  Detailed investigations of individual basins across the continent in terms of this partition indicate that the control over lateral transport of subsurface water is primarily a function of the subsurface geology.  Further, a marked incongruity between the surface drainage flow direction and groundwater flow direction is apparent in several cases – particularly where regional groundwater flow has developed – suggesting that surface drainage as a result of elevation is only partially indicative of subsurface flow regimes.  The modulation of surface drainage by the groundwater system suggests that groundwater flow is a significant portion of the continental water cycle.  Hence, this wide range of effects attributable to groundwater flow implies that the groundwater reservoir should be included in climate modeling efforts, particularly if estimates of future water resource availability are a goal of such efforts.
Mendozana Distant 1906
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Mendozana

description: Mendozana Distant, 1906
Mendozana Distant 1906a: 152.
Fadylia Delétang 1919: 93.
Semaiophora Haupt 1918: 87.
Type species. Mendozana platypleura Distant, 1906.
Remarks. Currently the genus is known only from Argentina (Metcalf 1963a; Duffels & van der Laan 1985).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on pages 83-84, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
An epistemic value theory
Creators: name: Whitcomb, Dennis
Publisher: name: No Publisher Supplied
Year: 2007

description: For any normative domain, we can theorize about what is good in that domain.  Such theories include utilitarianism, a view about what is good morally.  But there are many domains other than the moral; these include the prudential, the aesthetic, and the intellectual or epistemic.  In this last domain, it is (for instance) good to be knowledgeable and bad to ignore evidence, quite apart from the morality, prudence, and aesthetics of these things.  This dissertation builds a theory that stands to the epistemic domain as utilitarianism stands to the moral domain.  It builds an epistemic value theory.
Mendozana antennaria
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Mendozana
Mendozana antennaria

description: Mendozana antennaria (Jacobi, 1907)
Tettigades antennaria Jacobi 1907b: 204.
Semaiophora dietherti Schmidt 1926: 5.
Type locality. Santiago del Estero, Argentina.
Remarks. The species is endemic to Argentina with records from Buenos Aires and Santiago del Estero Provinces (Jacobi 1907b; Torres 1945a). We collected examples in Chaco Province. The species is associated with the Chaco floristic province (Sanborn et al. 2011a).
New provincial records. Chaco, Rt. 11—12.5 km No. of Rt. 16, 28-XII-1986, J.E. Heath Coll. (one male, MSHC); Chaco, Rt. 11—12.5 km No. of Rt. 16, 28-XII-1986, F. Noriega coll. (one male, MSHC); Chaco, Rt. 11—12.5 km No. of Rt. 16, 28-XII-1986, J.E. & M.S. Heath Coll. (one male, MSHC); Chaco, Rt. 11—12.5 km No. of Rt. 16, 29-XII-1986, Al Sanborn Coll. (one male, MSHC); Chaco, Dto. 1 o de Mayo, Ruta 11, 12.5 km No. of Ruta 16, 29-XII-1988, Heath-Sanborn-Noriega Coll. (two males, MSHC); Chaco, Rt. 11—12.5 km No. of Rt. 16, 28-XII-1986, J.E. & M.S. Heath Coll. (one male, AFSC); Chaco, Dto. 1 o de Mayo, Ruta 11, 12.5 km No. of Ruta 16, 29-XII-1988, Heath-Sanborn-Noriega coll. (one male, AFSC); Prov. Chaco, Ruta 11, 12.5. km North of junction with Ruta 16, 12-I-1992, A.. Sanborn Coll. (two males, AFSC).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 84, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
The Institute of Medicine's 2001 report on palliative cancer care as an instrument of innovation in palliative oncology
Creators: name: Hanson, Christopher S.
Publisher: name: No Publisher Supplied
Year: 2007

description: This dissertation assesses the effectiveness of the 2001 Institute of Medicine (IOM) report on palliative cancer care at inducing innovations in cancer research and practice among key organizational stakeholders in the health care system, including those concerned with cancer research and the provision of health care. The IOM report on cancer palliation was written by the National Cancer Policy Board, a diverse group consisting of prominent scientists, health care providers, third party payors, social scientists, patient advocates and others who have an interest in the development of cancer research, practice, and financing. Between 1997 and 2005 the Board published reports on cancer prevention, control, diagnosis, treatment, and palliation, until it was reorganized as the National Cancer Policy Forum.The authors of the 2001 IOM report on cancer palliation found that patients who are dying of cancer usually face an enormous burden of physical discomfort, lost functionality, and psychological stress, as well as a strong possibility of economic hardship. The authors made ten recommendations, summarized into five program areas that address the need to improve research, practice, and reimbursement for palliative, supportive, and end-of-life care, and to improve the quality of educational materials oriented toward the patients with advanced cancer and their loved ones. Taken together these recommendations represent a complex organizational innovation, which the Board sought to induce by publishing the report. This dissertation presents a case study of induced diffusion of innovation, by policy entrepreneurship within an epistemic community. The analysis includes review of documents, content analysis of relevant parts of the National Cancer Institute research program from 1998--2005 and professional journals from 1994--2004, and semi-structured interviews with key informants. The findings show that although the report's recommendations were sound its impact was limited by entrenched cultures at NCI and among professional groups.
Cyrtolabulus suavis
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Cyrtolabulus
Cyrtolabulus suavis

description: Cyrtolabulus suavis (van der Vecht, 1963)
Material examined. INDIA: Karnataka: Bangalore rural, Hoskote (Gotipura forest), 15.v.1982, 2♂, coll. B. Mallik. Ramanagara (Sangama), 19.vi.1980, 1♀, coll. A.R.V. Kumar. 1♀, VVB 160 and 1♂, VVB 172.
Distribution. India: * Karnataka, Kerala, Tamil Nadu [Coimbatore]; Rajasthan [Udaipur, Jaisamand Sanctuary Wildlife], Uttarakhand.— Sri Lanka (Girish Kumar et al. 2015a).
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 30, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Insulin resistance in smokers undergoing smoking cessation a
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking increases risk for heart disease, but also abnormal blood sugar and insulin handling that can lead to diabetes. But exactly how smoking does these things has not been well studied. Strangely, smoking also leads to weight loss, while quitting leads to weight gain; just the reverse of what would be expected given the adverse effects of smoking on blood sugar handling. We propose a novel way to study how smoking does these things in humans by examining smokers before and after enrolling in an aggressive program to quit smoking, and then again after some of those quitters naturally resume smoking later on. This will tell us the effects of smoking, in both directions (quitting, as well as re-starting), on the body's handling of blood sugar and other associated features. We will use a sophisticated method that can simultaneously measure the body's blood sugar usage, the liver's response to insulin, and the body's ability to burn sugar and fats, as well as measure changes in fat and lean body tissues, distribution of fat across different regions of the body, and other markers related to the body's response to insulin. Smoking, and successful quitting, will be verified through breath and urine samples, and we will control for changes in diet and exercise habits that can affect weight and other related measurements. We expect that this study will give us new knowledge about the metabolic effects of both quitting and re-starting smoking. Our studies may lead to individualized treatments for cigarette smoking cessation and may also highlight the need for smokers to stop smoking if they do not want to get diabetes and heart disease.
Mendozana platypleura Distant 1906
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Mendozana
Mendozana platypleura

description: Mendozana platypleura Distant, 1906
Mendozana platypleura Distant 1906a: 153.
Semaiophora basimaculata Haupt 1918: 88.
Fadylia bruchi Delétang 1919: 93.
Type locality. Catamarca Province, Argentina.
Remarks. The species was reported from Buenos Aires, Catamarca, La Rioja, and San Juan Provinces (Haupt 1918; Torres 1945a). The reference to Córdoba in Torres (1945a) is a mistake for Catamarca based on the specimen label. We collected specimens in Catamarca, La Rioja, San Juan, and San Luis Provinces. The species is associated with the Chaco and Monte floristic provinces (Sanborn et al. 2011a).
New provincial records. San Luis, 8 km W Rt. 79 on Rt. 20, 7-XII-1981, M.S. & J.E. Heath Coll. (eight males, MSHC).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 84, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Epsilon de Saussure 1855
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Epsilon

description: Genus Epsilon de Saussure, 1855
Epsilon de Saussure 1855: 229, 252, name for division III of subgenus Leionotus de Saussure of genus Odynerus Latreille in de Saussure 1852: 169. Type species: Odynerus dyscherus de Saussure, 1852, by subsequent designation (van der Vecht 1967: 31).
Epsilon: Girish Kumar et al. 2014a: 5380 –5381.
Diagnosis. Mandibles stout, as long as clypeus, distinctly cross each other. Clypeus much wider than long, smooth, usually apically emarginate, sometimes truncate. Female with cephalic fovea present. Vertex sloping behind ocelli. Anterior face of pronotum with group of transverse striations medially, without foveae. Pronotal carina usually complete. Mesepisternum with epicnemial carina present. Pretegular carina well developed. Tegula as wide as long, not evenly rounded posteriorly, emarginate adjoining parategula and equaling parategula posteriorly. Mesoscutum and scutellum extensively punctate, without prescutal furrows. Axillary fossa narrower than long. Metanotum narrow, non-dentiform and angled, with little dorsal horizontal face and flat posterior vertical face. Propodeum short, devoid of superior carina. Propodeum not raised shelflike to same level as metanotum. Propodeal orifice wide dorsally. Propodeum with submarginal carina projecting as rounded lobe above valvula, valvula separated from submarginal carina posteriorly. T1 sessile, in dorsal view wider than long, about as wide as T2, not carinate. T2 with apical lamellae. Mid tibia with one apical spur. SMC2 basally acute, with second recurrent vein nearly or completely interstitial with SMC3 (Fig. 63). Prestigma equals to half length of pterostigma. ♂: F11 hook like, acute apically. Body length usually 10–12 mm.
Distribution. Australian and Oriental Regions.
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 30, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
MPEC 2024-J238 : 2024 JK8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 JK8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Zammara tympanum
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Zammara
Zammara tympanum

description: Zammara tympanum (Fabricius, 1803)
[Tettigonia] tympanum Fabricius 1803b: 40.
Type locality. Brazil.
Remarks. As stated in the analysis of Z. strepens, the references to Z. tympanum probably relate to Z. tympanum (Palisot de Beauvois, 1813) which is a junior synonym of Z. strepens. The references to locations for the species are only “ Argentina ” (Metcalf 1963a). Zammara tympanum has been recorded from Belize, Honduras, Guatemala, Costa Rica, Colombia, Brazil, Peru and Paraguay (Metcalf 1963a; Duffels & van der Laan 1985; Sanborn 2010; 2011a). The records from Paraguay also appear to be Z. strepens (Sanborn 2011a). We remove the species until specimens of the true Z. tympanum can be verified from Argentina.
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 84, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Fidicina mannifera
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Fidicina
Fidicina mannifera

description: Fidicina mannifera (Fabricius, 1803a)
Cicada plebeja Linnaeus 1767: 707 (non Scopoli, 1763).
Tettigonia mannifera Fabricius 1803a: 36.
Cicada cantatrix Germar 1830: 41.
Fidicina rana Walker 1850: 88.
Fidicina excavata Walker 1850: 92.
Fidicina divisa Walker 1858a: 16.
Fidicina africana Metcalf 1955: 267.
Type locality. South America.
Remarks. The previous references to Fidicina mannifera (Fabricius) from Misiones (e.g., Torres, 1946; Sanborn et al. 1995b) are now considered to be F. torresi as the type locality for F. torresi is Misiones and our specimens fit the description of F. torresi. Specimens which historically were identified as F. mannifera were split into multiple species and genera by Boulard & Martinelli (1996). Previously the species was known from the Antilles, Bolivia, Brazil, Colombia, Costa Rica, Ecuador, French Guiana, Guyana, Panama, Paraguay, Peru, and Surinam (Metcalf 1963a; Duffels & van der Laan 185; Boulard & Martinelli 1996; Sanborn 2010a; 2011a; 2011b) and had a more northerly distribution. The records from Paraguay also need confirmation as the specimens reported from Paraguay were collected across the Paraná River from the type locality and other collecting sites in Misiones for F. torresi (Sanborn 2011a). The specimen of F. mannifera reported from Tucumán (Hayward 1960) is considered a misidentification as it is significantly out of range of the taxon, the specimen probably belongs to F. affinis which has been recorded from neighboring provinces (Haupt 1918).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 85, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Oxidative Stress/Inflammation in Pulmonary Disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic obstructive pulmonary disease (COPD), often a cigarette smoking-induced severe and progressive lung disease, affects 13.1 million people and is the third leading cause of death in US. Despite its importance, there is no direct cure for COPD, and the mechanisms by which cigarette smoking triggers the disease remain largely unknown. Recently, an exciting new connection was found between COPD and the cigarette-induced dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a protein that when mutated causes the common inherited genetic disease called cystic fibrosis (CF). Similar to people with COPD, CF patients suffer from persistent airway infection and inflammation, mucus hypersecretion, and mucus plugging of the airway.

 In this study, we will now explore the possibility that COPD is in fact a cigarette smoking-induced form of CF. We will provide in depth insights into the mechanisms that link cigarette smoking to CFTR dysfunction through analysis of the lung cell response to CS and loss of CFTR function using state-of-the-art genomic and proteomic technologies. Additionally, we will use our well-established high throughput screening strategy to pinpoint the “protein quality control” pathways that are damaged upon cigarette smoke exposure and thereby discover new drug targets against COPD. This study will set the stage for our ultimate goal - discover chemical compounds that can restore lung function via rescuing CS-damaged CFTR function.
Epsilon burmanicum
Creators: name: Pannure, Arati
name: Carpenter, James M.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eumenidae
Epsilon
Epsilon burmanicum

description: Epsilon burmanicum (Bingham, 1897)
Material examined. No specimens examined.
Distribution. India: Karnataka [Mysore (Bandipur), Shivamogga], Puducherry [Karaikal], Tamil Nadu [Kallar, Tharangambadi]; Gujarat [Surat], Maharashtra, Odisha [Balasore].— Myanmar, Sri Lanka, Thailand (Giordani Soika 1994; Gusenleitner 2006; Girish Kumar et al. 2014a)
description: Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 30, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/258090
Proarna grisea
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Proarna
Proarna grisea

description: Proarna grisea (Fabricius, 1775)
[Tettigonia] grisea Fabricius 1775: 678.
Type locality. America.
Remarks. Berg (1879) stated that he had a specimen from Jujuy that corresponded well to the existing description. Delétang (1919) lists Argentina within the distribution of P. grisea but provides no specific location data. He also stated that he had not seen any specimens. The distribution for the species includes the West Indies, Guyana, Northern Peru, Ecuador and Venzuela (Metcalf 1963a; Sanborn 2007a) so it appears the species is distributed in the northwestern portion of the continent. The reference to P. grisea by Berg (1879) probably concerns P. insignis which is similar in general appearance to P. grisea and is common in the cloud forests of the northwesten portion of Argentina. We remove the species until additional specimens collected in Argentina confirm the presence of the species in the country.
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 85, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
TITF1 signature biomarkers for early lung cancer detection
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is more often curable when detected early in its course. Therefore, new approaches that enable the earlier detection of lung cancer are needed. Blood-based biomarkers represent one such approach. Here, we propose to combine a biology-based hypothesis with a genomic-scale exploration, to discover novel blood-based biomarkers. Our studies are based on TITF1, a transcription factor that functions in normal lung development, and is abnormally reactivated in lung cancers. We propose to identify the genes that are transcriptionally activated by TITF1 in lung cancers. Of these, we will further identify the subset encoding secreted proteins, and determine if they are also detectable in the blood of patients with lung cancer. Preliminary studies from our lab, and from mouse lung cancer models, support the rationale. Our studies will lead to the nomination and initial evaluation of novel blood-based biomarkers for the early detection of lung cancer, and may ultimately assist in early detection improving patient outcomes.
Cigarette Producer Responsibility Project
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This Exploratory/Developmental Research Project seeks to establish a policy link between cigarette butt pollution of the environment and the environmental principle of Extended Producer Responsibility (EPR). In the long run, such a principle, applied to tobacco products, will open new channels for policy research by linking tobacco use to environmental degradation, encouraging regulatory interventions through environmental law, and holding the tobacco industry responsible for resulting harms and requisite waste cleanup cost-recovery and other solutions. To accomplish this goal, the Cigarette Butt Pollution Project will commission a series of policy, legal and legislative analyses to determine if and how Extended Producer Responsibility (EPR) may be applied to the tobacco industry regarding the environmental impact of tobacco product waste. It will convene two expert group meetings to discuss the findings of the commissioned papers regarding industry liability, litter fees and potential litigation to recover costs; possible take-back options for butt waste; regulatory and retail-based interventions for butt waste prevention; tobacco industry response to butt waste, including the influence of the industry with environmental, educational, and social networks; tobacco marketing regulations that may be implemented at the State level to change the product so that it is less of an environmental pollutant. CBPP will publish and present final reports on the above EPR-related areas of research and findings regarding butt waste elimination in public health, environmental and waste management journals and meetings.