cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Consciousness, Information, Electromagnetism and Water
Creators: name: Henry, Marc
Publisher: name: Substantia
Year: 2020

description: There are very few things that modern science does not yet understand. One of them is consciousness; the other is water. Our main idea was then that if consciousness and water are still deep mysteries for science, may be it could be because these apparently two different problems are in fact deeply entangled. Shading light on one of them may thus well have the wanted effect of illuminating the other. Here we explore the idea that it exists a mirror relationship between an immaterial pair acting on an immaterial world formed by consciousness and information on the one hand and a pair acting on a material world formed by electromagnetic radiations and water on the other hand. By using group theoretical arguments applied to the famous Maxwell’s equations, it is formally deduced that the external visible world les not a 4D space-time continuum (named M4 hereafter), but rather a 5D-space-time-scale hyper-surface (named C5 hereafter) embedded in the 6D-continuum of consciousness (named V6 hereafter) identified with the vacuum state of quantum physics or the ether (dynamical background) of general relativity. The new fifth degree of freedom in C5 is associated to the ability of living things to grow from small sizes to large sizes by leaving invariant its identity at all scales. The sixth degree of freedom in V6 is associated to the possibility of living either as a virtual non-observable entity or as a non-virtual observable entity. In both cases, life is associated to the ability of managing information stored in the intrinsic quantum structure of the V6-ether or in the water shells surrounding any living cell in the C5-hypersurface. Memory capacities and associated bandwidths may be quantitatively evaluated directly from theory and compared to what is observed experimentally giving confidence in the proposed approach. It follows directly from the modeling that space, time and mass should be considered as creations of consciousness in the form of persistent bits field, bringing strong support to eastern ways of philosophical thinking based were Tao or Vacuity are the only non-dual realities. For western minds, the modeling has the great advantage of explaining clearly what is life and consciousness in a mathematical frame unifying physics, chemistry and biology.
description: Substantia, Vol. 4 No. 1 (2020)
Leonardo and the Florence Canal. Sheets 126-127 of the Codex Atlanticus
Creators: name: Camerota, Filippo
Publisher: name: Substantia
Year: 2020

description: The folios 126 r-v and 127 r-v of the Codex Atlanticus represent the most exhaustive account of a project developed by Leonardo over many years: the construction of a waterway between Florence and the sea. This navigable canal was supposed to restore the country from the Arno floods and encourage commercial traffic, bringing wealth to the entire region. Its length of no less than 72 km, the system of automatic locks designed to overcome the total height difference of 34 meters between Florence and Pisa, and the idea of ​​feeding it with a water reserve located in Valdichiana would have made it one of the most imposing and technologically advanced hydraulic works of the time.
description: Substantia, Vol. 4 No. 1 (2020)
Investigating bioreactor substrates for water quality applications
Creators: name: Johnson, Philip H
Publisher: name: University of Lincoln
Year: 2024
Subjects: D443 - Water resource management

description: Woodchip bioreactors and other edge-of-field water treatment solutions are being increasingly used to address nutrient pollution in freshwater caused by agricultural subsurface drainage. This study evaluates the efficacy of low-cost bioreactor substrates and a steel-waste filter in reducing levels of nitrates and phosphorus in water. In addition to this, the effect of these substrates on the breakdown of clopyralid herbicide is also investigated. Small-scale laboratory bioreactors and steel-waste filters were used to simulate the conditions of a full-size bioreactor while testing different substrate combinations. The woodchip bioreactor achieved average nitrate removal efficiencies of 40.2%, rising to 60.5% with the addition of biomass bottom ash (straw) from an influent water concentration of 42.73mg Nitrate(N)/l. Both of these results are following a hydraulic retention time (HRT) of 48hrs. The steel-waste phosphate filter successfully reduced soluble phosphorus concentrations from an average of 2.84±0.41 to 4.30±0.44 mg/l P after 30 minutes of exposure yielding a max reduction of 87%. The woodchip bioreactor also demonstrated an increase in the rate of clopyralid breakdown. An average reduction in clopyralid concentration of 60% was achieved in a 36-hour period, this equates to a vastly reduced half-life (D50) compared with laboratory and field conditions. The results indicate that edge-of-field woodchip bioreactors, paired with steel-waste filters could be effective in treating agricultural wastewater for nutrient and clopyralid herbicide pollution.
Investigating bioreactor substrates for water quality applications
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: D443 - Water resource management

description: Woodchip bioreactors and other edge-of-field water treatment solutions are being increasingly used to address nutrient pollution in freshwater caused by agricultural subsurface drainage. This study evaluates the efficacy of low-cost bioreactor substrates and a steel-waste filter in reducing levels of nitrates and phosphorus in water. In addition to this, the effect of these substrates on the breakdown of clopyralid herbicide is also investigated. Small-scale laboratory bioreactors and steel-waste filters were used to simulate the conditions of a full-size bioreactor while testing different substrate combinations. The woodchip bioreactor achieved average nitrate removal efficiencies of 40.2%, rising to 60.5% with the addition of biomass bottom ash (straw) from an influent water concentration of 42.73mg Nitrate(N)/l. Both of these results are following a hydraulic retention time (HRT) of 48hrs. The steel-waste phosphate filter successfully reduced soluble phosphorus concentrations from an average of 2.84±0.41 to 4.30±0.44 mg/l P after 30 minutes of exposure yielding a max reduction of 87%. The woodchip bioreactor also demonstrated an increase in the rate of clopyralid breakdown. An average reduction in clopyralid concentration of 60% was achieved in a 36-hour period, this equates to a vastly reduced half-life (D50) compared with laboratory and field conditions. The results indicate that edge-of-field woodchip bioreactors, paired with steel-waste filters could be effective in treating agricultural wastewater for nutrient and clopyralid herbicide pollution.
A Physical and Computational Investigation into Rotating Electrical Machine Design for The Purpose of Optimising Air Flow Balance with Respect to Heat Rejection
Creators: name: Hammond, Matthew
Publisher: name: University of Lincoln
Year: 2024
Subjects: H100 - General engineering

description: This research set out to deliver a method of air flow redistribution to demonstrate a balanced rotor and stator predicted temperature of a mid range rotating electrical machine to within 2.5% with a maintained original efficiency and the temperature prediction should be proven based on air flow characteristics predicted via CFD and specified within MotorCAD. To achieve this a methodology of using an experimental rig to validate numerical baseline predictions was used and the validated model was used to investigate flow in different scenarios. The results from the study show that controlling and improving the direction and smoothness of the air at the inlet region of the fan can have a number of significant advantages to the flow split seen in the machine and also the power requirements of the fan. Importantly, it is shown that the excess flow through the barrel has an impact on the rotor flow due to the strength of the air jet coming from the barrel blocking the air through the rotor at the fan inlet region. The study concludes that by air flow improvements alone a predicted temperature balance of 3.7% between rotor and stator can be achieved with the recommended flow improvements, with an improvement in machine efficiency of 0.047% shown.
Peer Review - Critical Feedback or Necessary Evil?
Creators: name: Rasmussen, Seth C
Publisher: name: Substantia
Year: 2020

description: Anyone who has participated in scientific publishing, either as author or editor, has dealt with the process of peer review. Of course, individual opinions on peer review vary, with viewpoints ranging from it being an important part of ensuring the quality and reliability of scientific publications, to thoughts that the process as a whole is completely broken. Unfortunately, it also seems that authors often look at peer review as being a painful exercise forced upon them by journals, while those serving as reviewers too often see it as something expected of them, but not important enough to spend considerable effort performing.
description: Substantia, Vol. 4 No. 1 (2020)
A Physical and Computational Investigation into Rotating Electrical Machine Design for The Purpose of Optimising Air Flow Balance with Respect to Heat Rejection
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: H100 - General engineering

description: This research set out to deliver a method of air flow redistribution to demonstrate a balanced rotor and stator predicted temperature of a mid range rotating electrical machine to within 2.5% with a maintained original efficiency and the temperature prediction should be proven based on air flow characteristics predicted via CFD and specified within MotorCAD. To achieve this a methodology of using an experimental rig to validate numerical baseline predictions was used and the validated model was used to investigate flow in different scenarios. The results from the study show that controlling and improving the direction and smoothness of the air at the inlet region of the fan can have a number of significant advantages to the flow split seen in the machine and also the power requirements of the fan. Importantly, it is shown that the excess flow through the barrel has an impact on the rotor flow due to the strength of the air jet coming from the barrel blocking the air through the rotor at the fan inlet region. The study concludes that by air flow improvements alone a predicted temperature balance of 3.7% between rotor and stator can be achieved with the recommended flow improvements, with an improvement in machine efficiency of 0.047% shown.
Recommendations for refinement of the water-smartness framework and its transformation into a dashboard-type software
Creators: name: Cardoso, Maria Adriana
name: Silva, Catarina
name: Rosa, Maria João
name: Alegre, Helena
name: Ugarelli, Rita
name: Bosco, Camillo
name: Raspati, Gema
Publisher: name: Zenodo
Year: 2022

description: One of the key objectives of B-WaterSmart is to deliver a water-smartness assessment framework (BWS AF) fully tested in the six Living Labs (LLs) of the project. This deliverable aims at providing first recommendations to support both the refinement of the BWS AF and the development of the corresponding dashboard. This deliverable describes (i) the approach followed to obtain the recommendations within the innovation alliance (InAll), the InAll process, and an overview of the testing process of BWS AF version V0. It further presents (ii) the feedback on the framework from the LL problem-owners, the respective analysis, and subsequent recommendations both for refinement of the framework, and the development of the dashboard-type software to facilitate its use.
The Identification of in vitro Phenotypic Virulence Markers of Clostridium perfringens Isolated from Commensal and Clinical Sources
Creators: name: Brandreth, Emily
Publisher: name: University of Lincoln
Year: 2024
Subjects: D323 - Animal pathology

description: Necrotic enteritis is a multifactorial, complex disease that is prevalent within the poultry industry, subsequently costing US$6 billion, annually. The number of emerging cases has increased in recent years, attributed to the ban of antibiotic growth promoters. Necrotic enteritis is caused by the NetB toxin of Clostridium perfringens, however, the specific role of this toxin in the induction of disease is often disputed. The aim of this study was to phenotypically characterise isolates of C. perfringens, originating from UK sourced poultry of varying disease statuses, in an attempt to identify characteristics that may predict the potential virulence in vivo. Within this study, the phenotypic analysis involved the investigation of growth kinetics, biofilm production and haemolysis capability. The semi in vivo analysis of isolates utilised the Galleria mellonella larval model to identify whether phenotypic analysis would accurately represent virulence. This study demonstrated the effective use of rapid, cost effective assays to phenotypically characterise isolates of C. perfrignens. Significant differences (p<0.05) were identified in biofilm formation and G. mellonella morbidity, between isolates originating from commensal and clinical origins. The results of this study established that isolates of identical toxin types are able to produce varying phenotypic profiles, further highlighting the importance of characterisation in this manner.
Particular Symmetries: Group Theory of the Periodic System
Creators: name: Thyssen, Pieter
name: Ceulemans, Arnout
Publisher: name: Substantia
Year: 2020

description: To this day, a hundred and fifty years after Mendeleev's discovery, the overal structure of the periodic system remains unaccounted for in quantum-mechanical terms. Given this dire situation, a handful of scientists in the 1970s embarked on a quest for the symmetries that lie hidden in the periodic table. Their goal was to explain the table's structure in group-theoretical terms. We argue that this symmetry program required an important paradigm shift in the understanding of the nature of chemical elements. The idea, in essence, consisted of treating the chemical elements, not as particles, but as states of a superparticle. We show that the inspiration for this came from elementary particle physics, and in particular from Heisenberg's suggestion to treat the proton and neutron as different states of the nucleon. We provide a careful study of Heisenberg's last paper on the nature of elementary particles, and explain why the Democritean picture of matter no longer applied in modern physics and a Platonic symmetry-based picture was called for instead. We show how Heisenberg's Platonic philosophy came to dominate the field of elementary particle physics, and how it found its culmination point in Gell-Mann's classification of the hadrons in the eightfold way. We argue that it was the success of Heisenberg's approach in elementary particle physics that sparked the group-theoretical approach to the periodic table. We explain how it was applied to the set of chemical elements via a critical examination of the work of the Russian mathematician Abram Ilyich Fet the Turkish-American physicist Asim Orhan Barut, before giving some final reflections.
description: Substantia, Vol. 4 No. 1 (2020)
Vladimir Nikolayevich Ipatieff (1867-1952) - The Eminent Russian-American Chemist of the First Half of the XX Century
Creators: name: Sztejnberg, Aleksander
Publisher: name: Substantia
Year: 2020

description: Vladimir Nikolayevich Ipatieff (1867–1952) was one of the most prominent chemists of the first half of the 20th century. He studied catalytic processes in organic chemistry. His discoveries include, among others, the explanation of the structure of isoprene, the method of obtaining butadiene from ethanol, dehydrogenation of alcohols to aldehydes and ketones, dehydration of alcohols to alkenes, including ethanol to ethylene, hydrogenation of benzene to cyclohexane, polymerization of ethylene in the presence of various catalysts. Much of his experimental studies were carried out at high pressure in a rotating autoclave, the so-called “Ipatieff bomb”. The purpose of this article was to familiarize readers with important events in the life of V. N. Ipatieff and his research activities, in particular with selected results of his experimental studies. In addition, the statements by American and Russian chemists about V. N. Ipatieff and his research were presented.
description: Substantia, Vol. 4 No. 1 (2020)
The Identification of in vitro Phenotypic Virulence Markers of Clostridium perfringens Isolated from Commensal and Clinical Sources
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: D323 - Animal pathology

description: Necrotic enteritis is a multifactorial, complex disease that is prevalent within the poultry industry, subsequently costing US$6 billion, annually. The number of emerging cases has increased in recent years, attributed to the ban of antibiotic growth promoters. Necrotic enteritis is caused by the NetB toxin of Clostridium perfringens, however, the specific role of this toxin in the induction of disease is often disputed. The aim of this study was to phenotypically characterise isolates of C. perfringens, originating from UK sourced poultry of varying disease statuses, in an attempt to identify characteristics that may predict the potential virulence in vivo. Within this study, the phenotypic analysis involved the investigation of growth kinetics, biofilm production and haemolysis capability. The semi in vivo analysis of isolates utilised the Galleria mellonella larval model to identify whether phenotypic analysis would accurately represent virulence. This study demonstrated the effective use of rapid, cost effective assays to phenotypically characterise isolates of C. perfrignens. Significant differences (p<0.05) were identified in biofilm formation and G. mellonella morbidity, between isolates originating from commensal and clinical origins. The results of this study established that isolates of identical toxin types are able to produce varying phenotypic profiles, further highlighting the importance of characterisation in this manner.
Astatine - The Elusive One
Creators: name: Kostecka, Keith Simeon
Publisher: name: Substantia
Year: 2020

description: Astatine has proven, since its isolation by Corson, Mackenzie and Segre in 1940 to be an element with a fascinating history with respect to its discovery, confirmation and naming. It has also proven to have an interesting set of physical and chemical properties as well as isotopes of significant note. This element also has several applications of note as well as a captivating chemistry and the question of whether it is or is not diatomic.
description: Substantia, Vol. 4 No. 1 (2020)
Außerschulische Integration von jungen Geflüchteten in Groß- und Kleinstädten
Creators: name: Pudelko, Tanja
name: Ghulam, Mustafa
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: Integration
subject: Geflüchtete
subject: Großstädte
subject: Kleinstädte
subject: 300 Sozialwissenschaften::320 Politikwissenschaft::320 Politikwissenschaft

description: Jede Ortsgröße hat Vor und Nachteile bezüglich der Integration von Migranten. Geht es speziell um die Integration von Geflüchteten (Politisches Bildungsforum Hamburg 2016), spielen die verschiedenen Stadtgrößen, also Groß und Kleinstädte eine besonders wichtige Rolle. Dieser Beitrag thematisiert eine kleine Studie zu dem Einfluss der Stadtgröße auf Integrationsprozesse junger (unter 30 jährigen) Geflüchteter mit den jeweiligen Vor- und Nachteilen, die in deutschen Großstädten (z.B. Berlin ca. 3,47 Mio. und München ca. 1,43 Mio.) und in Kleinstädten (z.B. Gotha ca. 48.000 Einwohner und Waldkraiburg mit ca. 23.000 Einwohner.) untergebracht wurden.
Ecological Factors Driving Cranial Morphology in Delphinidae
Creators: name: Brierton, Helen
Publisher: name: University of Lincoln
Year: 2024
Subjects: C100 - Biology
C161 - Marine biology
C350 - Marine zoology

description: Delphinidae have a highly modified skull, resulting from their secondary adaptation to a fully aquatic lifestyle. This is characterized by skull telescoping and the posterior migration of the nasal bones, resulting in a vertical arrangement of the nasal passages, facilitating breathing at the water surface. Across the family, skull shape is notoriously diverse, thought to be related to their ecological diversity, which makes delphinids an interesting family to study, considering the potential ecological factors driving morphological change.In this study, I used geometric morphometrics to quantify the shape changes in cranial morphology across the family Delphinidae, and test for correlations with potential ecological drivers. I tested the hypotheses that skull shape change correlates well with ecological descriptors, and that multiple ecological variables are needed to fully characterise the diverse skull morphologies present in the family. A total of 138 2D images and 34 3D models were collated from multiple sources. For each 2D image a set of 38 landmarks were digitised using ImageJ and 52 landmarks were placed on each 3D model using MorphoDig. Procrustes superimposition and Principal Component Analyses were performed in MorphoJ, thus creating a Morphospace plot of skull shape change in delphinids. Each specimen position was compared with 12 ecological variables that could be evolutionary drivers of skull shape change. These included characteristics associated with feeding ecology, acoustic ability, habitat characteristics and taxonomy. One-way ANOSIM and one-way PERMANOVA were performed to test for significance of any separations seen on the morphospace between the species assigned to each variable category. Finally, multicollinearity and multivariate correlations were carried out, to test for possible influence of multiple variables in skull shape change.My results showed that the variables best correlating with variations in skull shape are related to taxonomy, feeding ecology and melon size. Furthermore, multivariate testing showed that other feeding related variables (diet, dentition and dive depth) and whether a species occupies a coastal or a pelagic habitat, are also factors that correlate with cranial morphology. These results support previous suggestions that skull shape changes are driven by feeding differences and phylogenetic relationships, but also emphasize the importance of melon shape, which has not typically been considered as an important driver of cranial morphology. The results also support the hypothesis that more than one variable have contributed to the extensive diversity in skull shapes, implying co-dependency of several ecological factors in determining morphological change in this group.
FUTURISTIC TECHNOLOGY IN ARCHITECTURE & PLANNING - AUGMENTED AND VIRTUAL REALITY: AN OVERVIEW
Creators: name: ijscai
Publisher: name: Zenodo
Year: 2024

description: Speed has become a way of life. We are asymptotically piling data. Speed can be achieved with new designprocesses, techniques, and Technology. Innovations AR and VR are just some of the many forms oftechnologies that will play a key role in shaping the Architecture and Planning of tomorrow, making itfuture-ready and ushering in a new age of innovation. AR and VR in Architecture & Planning wereintroduced as assisting tools and has helped generate multiple design options, expanded possibilities ofvisualization, and provided us with more enhanced, detailed, and specific experience in real-time; enablingus to see the resultsof work on hand well before the commencement of the project. These tools are furtherdeveloped for city development decisions, helping citizens interact with local authorities, access publicservices, and plan their commute. After reviewing multiple research papers, it had been observed that eachone is moving forward with the changes brought by it, without entirely understanding its role. This paperprovides a summary of theappliance of AR & VR in architecture and planning
title: Basisbildung für Geflüchtete
title: Einflussfaktoren auf den Spracherwerb
titleType: Subtitle
Creators: name: Pudelko, Tanja
name: Ghulam, Mustafa
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: Integration
subject: Geflüchtete
subject: Spracherwerb
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::379 Bildungspolitik

description: Bildung ist eine wichtige Grundlage, um gut leben zu können und die gesellschaftliche Teilhabe zu stärken. Sprache ist hierfür ein erster, wichtiger Baustein. Doch gerade bei Geflüchteten können sich zusätzliche Hindernisse auf dem Weg des Spracherlernens ergeben, die ein bedarfsgerechtes Angebot unabdingbar machen.
title: Berufliche Herausforderung für Alleinerziehende (Analphabeten)
title: Ein Vergleich zwischen Deutschland und Österreich
titleType: Subtitle
Creators: name: Ghulam, Mustafa
name: Pudelko, Tanja
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: Alleinerziehende
subject: Analphabeten
subject: Deutschland
subject: Österreich
subject: 300 Sozialwissenschaften::370 Bildung und Erziehung::379 Bildungspolitik

description: Das Aufziehen eines Kindes ist eine große und ernsthafte Verantwortung, insbesondere dann, wenn diese von nur einem Elternteil getragen wird. Es stellt eine große Belastung für den Elternteil dar, wodurch nicht nur seine physische und psychische Gesundheit, sondern auch maßgeblich der Aspekt der beruflichen Perspektive betroffen und beeinflusst wird.
Collusion and Delegation under Information Control
Creators: name: Asseyer, Andreas
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: collusion
subject: information design
subject: delegation
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: This paper studies how information control affects incentives for collusion and optimal organizational structures in principal-supervisor-agent relationships. I consider a model in which the principal designs the supervisor's signal on the productive agent's private information and the supervisor and agent may collude. I show that the principal optimally delegates the interaction with the agent to the supervisor if either the supervisor's budget is large or the value of production is small. The principal prefers direct communication with the supervisor and agent if the supervisor's budget is sufficiently small and the value of production is high.
Ecological Factors Driving Cranial Morphology in Delphinidae
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C100 - Biology
C161 - Marine biology
C350 - Marine zoology

description: Delphinidae have a highly modified skull, resulting from their secondary adaptation to a fully aquatic lifestyle. This is characterized by skull telescoping and the posterior migration of the nasal bones, resulting in a vertical arrangement of the nasal passages, facilitating breathing at the water surface. Across the family, skull shape is notoriously diverse, thought to be related to their ecological diversity, which makes delphinids an interesting family to study, considering the potential ecological factors driving morphological change.In this study, I used geometric morphometrics to quantify the shape changes in cranial morphology across the family Delphinidae, and test for correlations with potential ecological drivers. I tested the hypotheses that skull shape change correlates well with ecological descriptors, and that multiple ecological variables are needed to fully characterise the diverse skull morphologies present in the family. A total of 138 2D images and 34 3D models were collated from multiple sources. For each 2D image a set of 38 landmarks were digitised using ImageJ and 52 landmarks were placed on each 3D model using MorphoDig. Procrustes superimposition and Principal Component Analyses were performed in MorphoJ, thus creating a Morphospace plot of skull shape change in delphinids. Each specimen position was compared with 12 ecological variables that could be evolutionary drivers of skull shape change. These included characteristics associated with feeding ecology, acoustic ability, habitat characteristics and taxonomy. One-way ANOSIM and one-way PERMANOVA were performed to test for significance of any separations seen on the morphospace between the species assigned to each variable category. Finally, multicollinearity and multivariate correlations were carried out, to test for possible influence of multiple variables in skull shape change.My results showed that the variables best correlating with variations in skull shape are related to taxonomy, feeding ecology and melon size. Furthermore, multivariate testing showed that other feeding related variables (diet, dentition and dive depth) and whether a species occupies a coastal or a pelagic habitat, are also factors that correlate with cranial morphology. These results support previous suggestions that skull shape changes are driven by feeding differences and phylogenetic relationships, but also emphasize the importance of melon shape, which has not typically been considered as an important driver of cranial morphology. The results also support the hypothesis that more than one variable have contributed to the extensive diversity in skull shapes, implying co-dependency of several ecological factors in determining morphological change in this group.
Exploring the Relationship between Gender and Character Representation within Multiplayer Online Battle Arena (MOBA) Games
Creators: name: Davies, Bethany
Publisher: name: University of Lincoln
Year: 2024
Subjects: G900 - Others in mathematical sciences

description: Frequently, video game characters are designed to conform to the expectations oftheir gender, this correlation between character design and gender has not beenfully explored. This thesis investigates character representation from three novelperspectives, exploring three elements of character design specifically in MOBA videogames, chosen for their popularity and gameplay similarity.This thesis is presented in three core studies, the first investigating character mechanics in the form of gameplay abilities. The research finds that male characters aremore likely to have abilities that enable them to be self-sufficient, whereas femalecharacters have more abilities that aid their allies in-game, inherently placing theminto a submissive role.The second part of this research explores the the relationship between gender andcharacter narrative. This study evaluates character lore through a thematic analysis,identifying the themes used in character storylines. The results find female charactersto be represented as vulnerable. However, as their story develops there is a characterprogression where they are often praised for being headstrong, independent, powerfuland strong. Male characters are described with acute flaws that challenge typicalmasculinity such as crying, weakness and being unwanted.The third and final area of investigation examines the visual appearance of charactersfrom a fresh perspective. This study identifies correlations between the amount ofskin gendered characters had on show and viewer perceptions of their sexiness andattractiveness.The findings from these three studies demonstrate the areas where gender influencesthe existing design of characters. This research could have real-world impacts onfuture character creations.
Human rights film festivals: activism in context
Creators: name: Tascón, Sonia Magdalena
Publisher: name: Monash University
Year: 2016
Subjects: Uncategorized

description:

This thesis explores human rights film festivals (HRFFs), how they developed in particular locations, through particular conceptions of human rights and how they continue to adapt with changing expectations from audiences and human rights bodies. In this thesis the tensions produced by human rights' search for universality and the locatedness of the festivals are explored in detail through two case studies one located i n Buenos Aires, South America; the other in New York, North America, which was the first human rights film festival worldwide. The recent rise in interest in film festival scholarship has considered to some degree the activist film festival but has not yet taken into account those formulated around human rights. Activist film festivals are configured quite differently to those centred on cinephilia, although there are intersections with them as well. The former, with their focus on social change enter the film festival landscape specifically formulated to enhance social or political change through the educative elements of the visual image. Although there is a significant scholarship on visual activism, or the use of images for humanitarian purposes, much of which is critical because of the distancing and mediating effect for these purposes, very few consider the specific effects of human rights discourse as visual images are used for activism. In this thesis I begin from the premise that film festivals are specific spaces for visual activism and that, further, the use of human rights as the organising discourse injects demands not present in other political modes of spectatorship. One of those is the universalising impulse of human rights, which I suggest here produces more of an internationalist perspective . As human rights became one of the few remaining viable political visions after the 1980s, these film festivals have grown in number globally , attested to by the existence of an umbrella organisation Human Rights Film Network, to which most, if not all, HRFFs, belong. As a project that takes a discursive approach, I view the coming together of films in a film festival, with human rights, as a merger that is at times an uneasy one because of the different demands made by films bei ng located in a film festival for human rights activism , but also rich with possibilities for engaging active spectators and social change. In this thesis I present research findings across two HRFFs, one from Buenos Aires, and the other in New York. Their distinct histories, organisational affiliations, cultural and political contexts have produced a diverse and compelling set of relationships between cinema and human rights.
Published eBook. Repository holds theses manuscript title page, abstract and copyright declaration. See link for online access to the book.
Exploring the Relationship between Gender and Character Representation within Multiplayer Online Battle Arena (MOBA) Games
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: G900 - Others in mathematical sciences

description: Frequently, video game characters are designed to conform to the expectations oftheir gender, this correlation between character design and gender has not beenfully explored. This thesis investigates character representation from three novelperspectives, exploring three elements of character design specifically in MOBA videogames, chosen for their popularity and gameplay similarity.This thesis is presented in three core studies, the first investigating character mechanics in the form of gameplay abilities. The research finds that male characters aremore likely to have abilities that enable them to be self-sufficient, whereas femalecharacters have more abilities that aid their allies in-game, inherently placing theminto a submissive role.The second part of this research explores the the relationship between gender andcharacter narrative. This study evaluates character lore through a thematic analysis,identifying the themes used in character storylines. The results find female charactersto be represented as vulnerable. However, as their story develops there is a characterprogression where they are often praised for being headstrong, independent, powerfuland strong. Male characters are described with acute flaws that challenge typicalmasculinity such as crying, weakness and being unwanted.The third and final area of investigation examines the visual appearance of charactersfrom a fresh perspective. This study identifies correlations between the amount ofskin gendered characters had on show and viewer perceptions of their sexiness andattractiveness.The findings from these three studies demonstrate the areas where gender influencesthe existing design of characters. This research could have real-world impacts onfuture character creations.
Investigating HSP90 as the molecular switch for cancer cell metastasis
Creators: name: Taylor, Laura
Publisher: name: University of Lincoln
Year: 2024
Subjects: C100 - Biology

description: Heat shock proteins (HSPs), play an essential role in housekeeping functions in the body. When these are mis-used, HSPs are thought to play a significant role in the mechanisms leading to cancer cell development, a main aspect of this being metastasis. Metastasis is the spread of cancer cells to other areas of the body, and is often linked to a poor prognosis for diagnosed patients. This makes metastasis a very important issue to understand, and control. The blocking of metastasis, resulting in the tumour to stay in one tissue, provides better scope for treatment, especially in the case of surgery. One such HSP of interest, Heat shock protein 90 (HSP90) is found in all tissues of the body, with its cumulative expression level under non-stress conditions being very high. A target to reduce of halt metastasis needs to be identified, this could also be used as a biochemical marker for cancer prognosis. The aims of this study are to observe HSP90 output over time, analyse its role in cancer cell motility, assess for the use of HSP90 as a potential biomarker for cancer prognosis, and to analyse the synergy between HSP90 and TOR inhibitors, with the possibility of therapeutic use of dual drugging regimes.HSP90, plays a role in many cellular processes, such as signally pathways and cell survival. Due to this, HSP90 has been identified as a promising cancer drug target due to its critical role in stabilization and activation of several of the oncoproteins required for driving cancer cell progression, including being implicated in metastasis. In this investigation, wound assays were used to visualise cancer cell metastasis over time, with and without a drugging regime. Rapamycin and 17-allylamino-17-demethoxy-geldanamycin (17-AAG) were investigated as a drugging regime to analyse synergistic lethality as a dual treatment for cancer. Cancer cells were analysed using Western Blot to identify presence and concentration of HSP90 in the cells, to identify the effectiveness of the drugging regime. This resulted in the reduction of cancer cell metastasis using the optimum dosing concentration of 0.5?M Rapamycin and 5.1?M 17-AAG. The use of western blots also resulted in images demonstrating the ability of HSP90 to be used as a biomarker for cancer prognosis. These findings are significant when considering drugging regimes in human trails which look to reduce cancer cell metastasis, and which look to use biomarkers to personalise treatment in future. The major findings of this study were the confirmation that HSP90 is strongly involved in cancer cell metastasis, that its phosphorylated residues can be used as marker of cancer prognosis, and the identification of a successful drugging regime by combining Rapamycin and 17-AAG.
List of sequences, resources, primers, plasmids, donors, guideRNA
Creators: name: Gemperle, Jakub
Publisher: name: University of Manchester
Year: 2022
Subjects: Medical biotechnology not elsewhere classified

description: Excel sheets with sequences of sequencing primers (genomic), chemicals, antibodies, guideRNA and catalogue of donors (+strategies) used in this project.
Separate files or together in "Excel file S1"
Investigating HSP90 as the molecular switch for cancer cell metastasis
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C100 - Biology

description: Heat shock proteins (HSPs), play an essential role in housekeeping functions in the body. When these are mis-used, HSPs are thought to play a significant role in the mechanisms leading to cancer cell development, a main aspect of this being metastasis. Metastasis is the spread of cancer cells to other areas of the body, and is often linked to a poor prognosis for diagnosed patients. This makes metastasis a very important issue to understand, and control. The blocking of metastasis, resulting in the tumour to stay in one tissue, provides better scope for treatment, especially in the case of surgery. One such HSP of interest, Heat shock protein 90 (HSP90) is found in all tissues of the body, with its cumulative expression level under non-stress conditions being very high. A target to reduce of halt metastasis needs to be identified, this could also be used as a biochemical marker for cancer prognosis. The aims of this study are to observe HSP90 output over time, analyse its role in cancer cell motility, assess for the use of HSP90 as a potential biomarker for cancer prognosis, and to analyse the synergy between HSP90 and TOR inhibitors, with the possibility of therapeutic use of dual drugging regimes.HSP90, plays a role in many cellular processes, such as signally pathways and cell survival. Due to this, HSP90 has been identified as a promising cancer drug target due to its critical role in stabilization and activation of several of the oncoproteins required for driving cancer cell progression, including being implicated in metastasis. In this investigation, wound assays were used to visualise cancer cell metastasis over time, with and without a drugging regime. Rapamycin and 17-allylamino-17-demethoxy-geldanamycin (17-AAG) were investigated as a drugging regime to analyse synergistic lethality as a dual treatment for cancer. Cancer cells were analysed using Western Blot to identify presence and concentration of HSP90 in the cells, to identify the effectiveness of the drugging regime. This resulted in the reduction of cancer cell metastasis using the optimum dosing concentration of 0.5?M Rapamycin and 5.1?M 17-AAG. The use of western blots also resulted in images demonstrating the ability of HSP90 to be used as a biomarker for cancer prognosis. These findings are significant when considering drugging regimes in human trails which look to reduce cancer cell metastasis, and which look to use biomarkers to personalise treatment in future. The major findings of this study were the confirmation that HSP90 is strongly involved in cancer cell metastasis, that its phosphorylated residues can be used as marker of cancer prognosis, and the identification of a successful drugging regime by combining Rapamycin and 17-AAG.
How do peers promote social inclusion of children with disabilities?A mixed-methods systematic review
Creators: name: Woodgate, Roberta L.
name: Gonzalez, Miriam
name: Demczuk, Lisa
name: Snow, Wanda M.
name: Barriage, Sarah
name: Kirk, Susan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Purpose: This mixed-methods systematic review synthesized findings from studies published between January 1, 2006 and July 31, 2018 on the social inclusion experiences of children with and without disabilities, as viewed from their own perspective, with a focus on how typically developing peers promote social inclusion. Method: Forty-five studies met the inclusion criteria. Data from included studies were synthesized by means of content analysis. Results: The findings detail the inner social inclusion experiences (e.g., feeling included, different) of children with disabilities and provide information regarding the influence of disability type (e.g., physical, social, affective) on typically developing peers’ responses (e.g., acceptance vs. rejection), peers’ explanations for social inclusion/exclusion, and peers’ relationships with children with disabilities. Barriers to social inclusion, supports, as well as strategies used to promote social inclusion, as perceived by peers and children with disabilities, are also reported. Conclusion: The findings of this review provide evidence that despite society’s efforts to promote social inclusion, children with disabilities continue to report feeling lonely and excluded, having limited contact socially outside of home, and encountering systemic barriers (e.g., bullying, discrimination). More research on the social inclusion experiences of children with disabilities beyond educational settings is needed, such as in the contexts of recreation and leisure, community, and employment.Implications for rehabilitationThe perspectives of children with and without disabilities need to be integrated in activities and programs aimed at promoting social inclusion.Teaching social inclusion strategies to children with and without disabilities is needed to help them deal with barriers.In addition to educational settings, rehabilitation clinicians need to promote social inclusion strategies in other contexts such as recreation and leisure, community, and employment contexts. The perspectives of children with and without disabilities need to be integrated in activities and programs aimed at promoting social inclusion. Teaching social inclusion strategies to children with and without disabilities is needed to help them deal with barriers. In addition to educational settings, rehabilitation clinicians need to promote social inclusion strategies in other contexts such as recreation and leisure, community, and employment contexts.
Physical fitness of children and adolescents with moderate to severe intellectual disabilities
Creators: name: Wouters, Marieke
name: Evenhuis, Heleen M.
name: Thessa I. M. Hilgenkamp
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Low levels of physical fitness are associated with low physical and mental health. The aims of this study were to assess the health-related physical fitness of children with intellectual disability (ID), and study the association of physical activity and motor development with physical fitness. Methods: One hundred and twenty-eight children with moderate to severe ID (83 boys; age 2–18 years) visiting specialised day programme centres engaged in field-based physical fitness tests (body composition, muscular strength, muscular endurance, and cardiorespiratory fitness). Scores were compared to reference values, and with linear regression analysis the association between the fitness outcomes and physical activity and motor development was studied. Results: High rates of overweight (23–25%) and obesity (10–15%) were found. A majority of the participants (71–91%) scored below reference values for muscular strength, endurance, and cardiorespiratory fitness tests. Physical activity and motor development were positively associated with scores on several fitness test (β = 0.27–0.44; p Conclusions: Children with moderate to severe ID visiting specialised day programme centres have strikingly low physical fitness levels. Policies and interventions to increase the physical fitness for this specific group of children are urgently needed, in which increasing physical activity and motor skills are expected to be effective components.Implications for rehabilitationStrikingly low levels of physical fitness were seen in children and adolescents with moderate to severe intellectual disabilities.This vulnerable group is in need of appropriate interventions to increase their physical fitness levels.Increasing the physical activity is a potential component in these interventions.Improving motor development will most likely lead to improved physical fitness as well. Strikingly low levels of physical fitness were seen in children and adolescents with moderate to severe intellectual disabilities. This vulnerable group is in need of appropriate interventions to increase their physical fitness levels. Increasing the physical activity is a potential component in these interventions. Improving motor development will most likely lead to improved physical fitness as well.