cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
54964: Newfoundland War Memorial Park
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Interior, showing wreaths and name plaque at base of Caribou Memorial.
Alois Madre: Die theologische Polemik gegen Raimundus Lullus
Creators: name: Platzeck, Erhard-W.
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 3/4 (1975): Römische Quartalschrift, Band 70, Heft 3/4
UrbanHistory4D - e22_IfEozNl5L_Hahnfried_duplicate
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building.The following files are available:Models: Hahnfried_lr.glb | Hahnfried.glb | Hahnfried_nelr.glb | Hahnfried_ne.glbMetadata: e22_IfEozNl5L_Hahnfried_duplicate.jsonOriginal Files: Hahnfried.zipThumbnails: Hahnfried_perspective_1.png | Hahnfried_perspective_2.png | Hahnfried_perspective_3.png | Hahnfried_perspective_4.pngEDM-XMLs: e22_IfEozNl5L_Hahnfried_duplicate_edm.xmlMets/Mods-XMLs: e22_IfEozNl5L_Hahnfried_duplicate_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Agraecina lineata
Creators: name: Beladjal, Lynda
name: Bouseksou, Samira
name: Kherbouche-Abrous, Ourida
name: Alioua, Youcef
name: Bosmans, Robert
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Liocranidae
Agraecina
Agraecina lineata

description: 2. Agraecina lineata (Simon, 1878)
Agraecina lineata; Simon 1932: 970; Bosmans 1999: 30; Touchi et al. 2018: 281. Boucherit et al. 2020: 64.
Citations (5): Algeria: without precise locality (Simon 1932). Aïn Defla: Bir Ould Khelifa (Boucherit et al. 2020).
Alger: Réghaia Estuary (Bosmans 1999); Zéralda, Forêt d’Oued El Aggar, Zéralda Game Reserve (Touchi et al. 2018). Tizi Ouzou: Mizrana Forest (Bosmans 1999).
Distribution: Western Mediterranean to Kazakhstan (World Spider Catalog 2024).
description: Published as part of Beladjal, Lynda, Bouseksou, Samira, Kherbouche-Abrous, Ourida, Alioua, Youcef & Bosmans, Robert, 2025, First Exhaustive Catalog of Spiders of Algeria (Arachnida: Araneae), pp. 1-185 in Zootaxa 5598 (1) on page 92, DOI: 10.11646/zootaxa.5598.1.1, http://zenodo.org/record/14971861
UrbanHistory4D - e22_iNIT8nHng
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building.The following files are available:Models: group_01Surface_Color_lr.glb | group_01Surface_Color.glb | group_01Surface_Color_nelr.glb | group_01Surface_Color_ne.glbMetadata: e22_iNIT8nHng.jsonOriginal Files: group_0.1Surface_Color.zipThumbnails: group_01Surface_Color_perspective_1.png | group_01Surface_Color_perspective_2.png | group_01Surface_Color_perspective_3.png | group_01Surface_Color_perspective_4.pngEDM-XMLs: e22_iNIT8nHng_edm.xmlMets/Mods-XMLs: e22_iNIT8nHng_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Agroeca maghrebensis Bosmans 1999
Creators: name: Beladjal, Lynda
name: Bouseksou, Samira
name: Kherbouche-Abrous, Ourida
name: Alioua, Youcef
name: Bosmans, Robert
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Liocranidae
Agroeca
Agroeca maghrebensis

description: 5. Agroeca maghrebensis Bosmans, 1999
Agroeca maghrebensis Bosmans 1999.
Citations (15): Aïn Temouchent: El Malah-El Ghella road (= Rio Salado)(Bosmans 1999). Batna: Monts de Belezma, Col Telmet (Bosmans 1999). Blida: Meftah, Djebel Zerouela (Bosmans 1999). Bordj Bou Arreridj: Mansoura 5 km East (Bosmans 1999); Sidi Embarek (Bosmans 1999). Bouira: Bechloul East, Oued Zaiane (Bosmans 1999); Col de Dirah, Oued Djenane (Bosmans 1999). Jijel: Ziama Mansouriah (Bosmans 1999). Laghouat: Laghouat, Oued M’zi (Bosmans 1999). Oran: Misserghin (Bosmans 1999). Sétif: Djebel Babor (Bosmans 1999); Magra North, Rasfa (Bosmans 1999). Skikda: Bouchtata Mahmoud (Bosmans 1999). Souk Ahras: Souk Ahras (Bosmans 1999).
Tlemcen: Tal Terny forest (Bosmans 1999).
Distribution: Algeria, Morocco, Tunisia (World Spider Catalog 2024).
description: Published as part of Beladjal, Lynda, Bouseksou, Samira, Kherbouche-Abrous, Ourida, Alioua, Youcef & Bosmans, Robert, 2025, First Exhaustive Catalog of Spiders of Algeria (Arachnida: Araneae), pp. 1-185 in Zootaxa 5598 (1) on page 93, DOI: 10.11646/zootaxa.5598.1.1, http://zenodo.org/record/14971861
Remigius Bäumer: Von Konstanz nach Trient
Creators: name: Gieraths, Paul-Gundolf
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 3/4 (1975): Römische Quartalschrift, Band 70, Heft 3/4
UrbanHistory4D - e22_Q9625ql8l
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building during the time from 1990-01-01 to 1990-01-02.The following files are available:Models: 2020-Markt_denkmalSurface_Color_lr.glb | 2020-Markt_denkmalSurface_Color.glb | 2020-Markt_denkmalSurface_Color_nelr.glb | 2020-Markt_denkmalSurface_Color_ne.glbMetadata: e22_Q9625ql8l.jsonOriginal Files: 2020-Markt_denkmalSurface_Color.zipThumbnails: 2020-Markt_denkmalSurface_Color_perspective_1.png | 2020-Markt_denkmalSurface_Color_perspective_2.png | 2020-Markt_denkmalSurface_Color_perspective_3.png | 2020-Markt_denkmalSurface_Color_perspective_4.pngEDM-XMLs: e22_Q9625ql8l_edm.xmlMets/Mods-XMLs: e22_Q9625ql8l_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Additional file 3 of Role of chemokine-mediated angiogenesis in resistance towards crizotinib and its reversal by anlotinib in EML4-ALK positive NSCLC
Creators: name: Wang, Shasha
name: Lou, Ning
name: Luo, Rongrong
name: Hao, Xuezhi
name: Liu, Yutao
name: Wang, Lin
name: Shi, Yuankai
name: Han, Xiaohong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Additional file 3: Figure S3. The functional enrichment and TCGA cohort analysis of chemokines related to crizotinib efficacy. (A) Biological processes (BPs) enriched among the interaction molecules of 12 chemokines; (B) Angiogenesis-related BPs enriched among the interaction molecules by Cytoscape; (C) The mRNA expression of 4 chemokines between lung adenocarcinoma (LUAD), lung squamous carcinoma (LUSC), and normal tissue from the GEPIA database; (D) Kaplan-Meier curves of disease-free survival (DFS) and overall survival (OS) for CCL20 mRNA expression in TCGA cohort. * p
Agroeca inopina O. Pickard-Cambridge 1886
Creators: name: Beladjal, Lynda
name: Bouseksou, Samira
name: Kherbouche-Abrous, Ourida
name: Alioua, Youcef
name: Bosmans, Robert
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Liocranidae
Agroeca
Agroeca inopina

description: 6. Agroeca inopina O. Pickard-Cambridge, 1886
Agroeca inopina O.Pickard-Cambridge 1886: 71; Abrous-Kherbouche et al. 1997: 79; Bosmans 1999: 29.
Citations (6): Béjaïa: foret d’Akfadou (Bosmans 1999). Médéa: Djebel Mouzaia (Bosmans 1999). Tizi Ouzou: Massif du Djurdjura, Aït Ouabane (Bosmans 1999); Tala Guilef (Abrous-Kherbouche et al. 1997; Bosmans 1999); Yakouren (Bosmans 1999). Tlemcen: foret d’Hafir (Bosmans 1999).
Distribution: Algeria, Europe, Turkey, Iran (World Spider Catalog 2024).
description: Published as part of Beladjal, Lynda, Bouseksou, Samira, Kherbouche-Abrous, Ourida, Alioua, Youcef & Bosmans, Robert, 2025, First Exhaustive Catalog of Spiders of Algeria (Arachnida: Araneae), pp. 1-185 in Zootaxa 5598 (1) on page 93, DOI: 10.11646/zootaxa.5598.1.1, http://zenodo.org/record/14971861
Additional file 2 of Percutaneous core-needle biopsy before and immediately after coaxial microwave ablation in solid non-small cell lung cancer: the comparison of genomic testing from specimens
Creators: name: Xu, Sheng
name: He, Lei
name: Qi, Jing
name: Kong, Fan-Lei
name: Bie, Zhi-Xin
name: Li, Yuan-Ming
name: Wang, Zheng
name: Li, Xiao-Guang
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2
UrbanHistory4D - e22_StzNVgCC-
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building in its state since 1990-01-01.The following files are available:Models: 2020-rathaus_1Surface_Color_lr.glb | 2020-rathaus_1Surface_Color.glb | 2020-rathaus_1Surface_Color_nelr.glb | 2020-rathaus_1Surface_Color_ne.glbMetadata: e22_StzNVgCC-.jsonOriginal Files: 2020-rathaus_1Surface_Color.zipThumbnails: 2020-rathaus_1Surface_Color_perspective_1.png | 2020-rathaus_1Surface_Color_perspective_2.png | 2020-rathaus_1Surface_Color_perspective_3.png | 2020-rathaus_1Surface_Color_perspective_4.pngEDM-XMLs: e22_StzNVgCC-_edm.xmlMets/Mods-XMLs: e22_StzNVgCC-_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Apostenus algericus Bosmans 1999
Creators: name: Beladjal, Lynda
name: Bouseksou, Samira
name: Kherbouche-Abrous, Ourida
name: Alioua, Youcef
name: Bosmans, Robert
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Liocranidae
Apostenus
Apostenus algericus

description: 7. Apostenus algericus Bosmans, 1999
Apostenus algericus Bosmans, 1999: 32.
Citations (1): El Bayadh: Les Arabaouattes North East (Bosmans 1999).
Distribution: Algeria (World Spider Catalog 2024); species only known from the type locality.
description: Published as part of Beladjal, Lynda, Bouseksou, Samira, Kherbouche-Abrous, Ourida, Alioua, Youcef & Bosmans, Robert, 2025, First Exhaustive Catalog of Spiders of Algeria (Arachnida: Araneae), pp. 1-185 in Zootaxa 5598 (1) on page 93, DOI: 10.11646/zootaxa.5598.1.1, http://zenodo.org/record/14971861
Additional file 4 of Role of chemokine-mediated angiogenesis in resistance towards crizotinib and its reversal by anlotinib in EML4-ALK positive NSCLC
Creators: name: Wang, Shasha
name: Lou, Ning
name: Luo, Rongrong
name: Hao, Xuezhi
name: Liu, Yutao
name: Wang, Lin
name: Shi, Yuankai
name: Han, Xiaohong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Additional file 4: Figure S4. The functional enrichment and GEPIA analysis of significant genes and the results of cell apoptosis assay. (A) Angiogenesis-related BPs enriched among the differentially expressed genes from GSE94089 dataset by Cytoscape; (B) Effect of si-CCL2, si-CCL20, si-CCL24, and si-CX3CL1 treatments on cell apoptosis in H3122CR; (C) GEPIA correlation analysis for CCL20 with VEGFA, IL6, CCL2, and CCL24. ns: not significant.
Sermo ultimus, quem fecit Dominus Innocentius papa tercius in Lateranensi concilio gernerali
Creators: name: Imkamp, Wilhelm
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 3/4 (1975): Römische Quartalschrift, Band 70, Heft 3/4
Status and Powering Test Results of HTS Undulator Coils at 77 K for Compact FEL Designs
Creators: name: Richter, S. C.
name: Ballarino, A.
name: Bernhard, A.
name: Müller, A-S.
name: Nes, T. H.
name: Schoerling, D.
Publisher: name: JACoW Publishing
Year: 2022

description: The production of low emittance positron beams for future linear and circular lepton colliders, like CLIC or FCC-ee, requires high-field damping wigglers. Just as compact free-electron lasers (FELs) require high-field but as well short-period undulators to emit high energetic, coherent photons. Using high-temperature superconductors (HTS) in the form of coated ReBCO tape superconductors allows higher magnetic field amplitudes at 4 K and larger operating margins as compared to low-temperature superconductors, like Nb-Ti. This contribution discusses the development work on superconducting vertical racetrack (VR) undulator coils, wound from coated ReBCO tape superconductors. The presented VR coils were modularly designed with a period length of 13 mm. Powering tests in liquid nitrogen of multiple vertical racetrack coils were performed at CERN. The results from the measurements are presented for three VR coils and compared with electromagnetic simulations.
ASPECTOS FILOSÓFICOS E ATEMPORAIS DA TEORIA POLÍTICA DE MAQUIAVEL
Creators: name: Avaetê de Lunetta e Rodrigues Guerra
name: Narbal de Marsillac Fontes
Publisher: name: Zenodo
Year: 2024

description: Trata-se, neste trabalho, de analisar as ideias e contribuições de Maquiavel para a Itália do século XVI, quando o Renascimento alcança seu auge, testemunhando fatos políticos envolvendo sua cidade natal, Florença, onde havia um grande desejo por parte da população que almejava mudanças, inspirando o sábio Florentino em seus escritos e pensamentos, gerando, assim, um forte sentimento de esperança em uma unidade política. O presente trabalho investiga tópicos referentes aos períodos Trecento e Quattrocento, fundamentais na construção do modelo político italiano da época, apresentando as influências históricas que levaram Nicolau Maquiavel a desenvolver suas teorias. A pesquisa foi desenvolvida tendo por base as obras O Príncipe e Discorsi, além das contribuições de importantes comentadores. A hipótese de investigação da presente dissertação afirma que Maquiavel foi responsável pela “invenção” de uma teoria política própria e inovadora para a época, desmistificando a ideia de que o Florentino seria apenas um agente revelador dos fatos que estavam ocorrendo no seu tempo. O método de investigação terá por objetivo demonstrar que, mesmo não tendo um caráter moralista, Maquiavel foi capaz de estabelecer princípios fundamentais da conduta humana no sentido filosófico, ao analisar aspectos da realidade política da época, instaurando um novo olhar, na tentativa de investigar o que é possível e eficiente no universo de alternativas aos que procuram vitórias nas suas práticas e ações, extraindo lições obtidas em eventos pregressos, que farão toda a diferença na formulação de sua teoria política. Também discute o conceito de virtù, utilizado pelo autor em seus escritos e frequentemente abordado por filósofos e pesquisadores de diversas épocas, fazendo uma análise das obras Discorsi e "O Príncipe" enquanto obra de aconselhamento a novos governantes, explorando algumas consequências destas abordagens. Por fim, no último capítulo, faremos um apanhado geral em torno das questões éticas e religiosas presenciadas pelo autor, discutindo religião e política, dialogando com as biografias de referência, objetivando um maior entendimento acerca das contribuições filosóficas trazidas por Maquiavel para a Itália da época.
Zum "Lot-Sarkophag" von S. Sebastino in Rom
Creators: name: Deckers, Johannes G.
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 3/4 (1975): Römische Quartalschrift, Band 70, Heft 3/4
Norbert Trippen: Das Domkapitel und die Erzbischofswahlen in Köln 1821-1926
Creators: name: Weber, Christoph
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 1/2 (1975): Römische Quartalschrift, Band 70, Heft 1/2
Additional file 2 of Role of chemokine-mediated angiogenesis in resistance towards crizotinib and its reversal by anlotinib in EML4-ALK positive NSCLC
Creators: name: Wang, Shasha
name: Lou, Ning
name: Luo, Rongrong
name: Hao, Xuezhi
name: Liu, Yutao
name: Wang, Lin
name: Shi, Yuankai
name: Han, Xiaohong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Additional file 2: Figure S2. Kaplan-Meier survival analysis of 5 significant chemokines with overall survival (OS) and time-dependent operating characteristic curve (ROC) of CCL20. (A) IL-8; (B) CCL24; (C) CXCL9; (D) CXCL13; (E) IL-6; Time-dependent operating ROC of CCL20 (F) for progression-free survival (PFS); (G) for OS.
52346: Operations on the Ancre
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Working party of the Manchester Regiment moving up to the trenches.
Additional file 2 of Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up
Creators: name: Centeno, Christopher J.
name: Fausel, Zachary
name: Dodson, Ehren
name: Berger, Dustin R.
name: Steinmetz, Neven J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Supplementary Material 2.
EL PSICÓPATA SUBCLÍNICO:  SUS MANIFESTACIONES Y COMPORTAMIENTO
Creators: name: Andrés Alpiste Pérez
Publisher: name: Zenodo
Year: 2014

description: Resumen: Este trabajo trata de abordar una de las caras de la psicopatía que debido a que su incidencia criminal es menor – aunque no en el grado en el que afecta a nuestra vida diaria– pasa más desapercibida, convivimos con ella y de hecho en muchos casos está socialmente aceptada como el comportamiento adecuado (principalmente en determinados ámbitos laborales). La psicopatía subclínica ha recibido menos atención que la psicopatía clínica ya que los efectos de esta última son llamativos e impactan e interesan en gran medida a la sociedad. Pero eso no resta importancia al impacto que las personalidades psicopáticas pueden tener en nuestra vida diaria, el nivel de manipulación que pueden alcanzar así como los medios que utilizan para lograr esa manipulación. Palabras clave: Psicópata integrado/subclínico, falta de empatía, parasitismo, encanto superficial, narcisismo.
sj-docx-1-slg-10.1177_0160323X221110484 - Supplemental material for Is Florida Really that Interesting? State Geographic Bias in Public Administration Research
Creators: name: Fowler, Luke
name: Fox, Dalten
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-docx-1-slg-10.1177_0160323X221110484 for Is Florida Really that Interesting? State Geographic Bias in Public Administration Research by Luke Fowler and Dalten Fox in State and Local Government Review
ATP6V1A: from organelle acidification to Early Onset Epileptic Encephalopathies
Creators: name: ESPOSITO, ALESSANDRO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: V-type proton (H+) ATPase (v-ATPase) is a multi-subunit proton pump that regulates pH homeostasis in all eukaryotic cells; in neurons, v-ATPase plays additional and unique roles in synapse function. Through whole exome sequencing, we identified de novo heterozygous mutations (p.Pro27Arg, p.Asp100Tyr, p.Asp349Asn, p.Asp371Gly) in ATP6V1A, encoding the A subunit of v-ATPase, in four patients with developmental encephalopathy with epilepsy. Early manifestations, observed in all patients, were developmental delay and febrile seizures, evolving to encephalopathy with profound delay, hypotonic/dyskinetic quadriparesis and intractable multiple seizure types in two patients (p.Pro27Arg, p.Asp100Tyr), and to moderate delay with milder epilepsy in the other two (p.Asp349Asn, p.Asp371Gly). Modelling performed on the available prokaryotic and eukaryotic structures of v-ATPase predicted p.Pro27Arg to perturb subunit interaction, p.Asp100Tyr to cause steric hindrance and destabilize protein folding, p.Asp349Asn to affect the catalytic function and p.Asp371Gly to impair the rotation process, necessary for proton transport. We addressed the impact of p.Asp349Asn and p.Asp100Tyr mutations on ATP6V1A expression and function by analysing ATP6V1A-overexpressing HEK293T cells and patients' lymphoblasts. The p.Asp100Tyr mutant was characterized by reduced expression due to increased degradation. Conversely, no decrease in expression and clearance was observed for p.Asp349Asn. In HEK293T cells overexpressing either pathogenic or control variants, p.Asp349Asn significantly increased LysoTracker� fluorescence with no effects on EEA1 and LAMP1 expression. Conversely, p.Asp100Tyr decreased both LysoTracker� fluorescence and LAMP1 levels, leaving EEA1 expression unaffected. Both mutations decreased v-ATPase recruitment to autophagosomes, with no major impact on autophagy. Experiments performed on patients' lymphoblasts using the LysoSensor? probe revealed lower pH of endocytic organelles for p.Asp349Asn and a reduced expression of LAMP1 with no effect on the pH for p.Asp100Tyr. These data demonstrate gain of function for p.Asp349Asn characterized by an increased proton pumping in intracellular organelles, and loss of function for p.Asp100Tyr with decreased expression of ATP6V1A and reduced levels of lysosomal markers. We expressed p.Asp349Asn and p.Asp100Tyr in rat hippocampal neurons and confirmed significant and opposite effects in lysosomal labelling. However, both mutations caused a similar defect in neurite elongation accompanied by loss of excitatory inputs, revealing that altered lysosomal homeostasis markedly affects neurite development and synaptic connectivity. This study provides evidence that de novo heterozygous ATP6V1A mutations cause a developmental encephalopathy with a pathomechanism that involves perturbations of lysosomal homeostasis and neuronal connectivity, uncovering a novel role for v-ATPase in neuronal development.
In vitro and in vivo characterization of the RE-1 Silencing Transcription Factor (REST) activity under neuroinflammatory conditions
Creators: name: BUFFOLO, FEDERICA
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: The ability to specifically target epigenetic and molecular mechanisms involved in neuronal development could be an alternative therapeutic strategy for neuroinflammatory/neurodegenerative disorders such as Multiple Sclerosis (MS). The transcriptional repressor RE1-Silencing Transcription Factor (REST) regulates neurogenesis and neuronal identity through cell-specific gene repression, allowing expression of its targets in mature neurons where REST is quiescent. REST dysregulation has been implicated in several neurodegenerative disorders, including Alzheimer and Huntington diseases, tumors of the nervous system, and epilepsy.
We found that REST is overexpressed in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), suggesting that its dysregulation might be an important factor in the pathogenesis of the disease. Starting from these observations, we have firstly analyzed the expression of REST target genes in EAE and characterized the cell-specificity of REST overexpression, investigating the differential contribution of neuronal and glial cell populations to REST upregulation. Moreover, in order to mimic the inflammatory EAE scenario, we have analyzed REST activity in primary neuron cultures treated with various pro-inflammatory cytokines. Altogether, this study provides the basis for understanding the molecular mechanisms of REST expression during brain inflammation and its implication in the subsequent neurodegenerative processes.
Cybaeodes carusoi Platnick & Di Franco 1992
Creators: name: Beladjal, Lynda
name: Bouseksou, Samira
name: Kherbouche-Abrous, Ourida
name: Alioua, Youcef
name: Bosmans, Robert
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Liocranidae
Cybaeodes
Cybaeodes carusoi

description: 8. Cybaeodes carusoi Platnick & Di Franco, 1992
Cybaeodes carusoi Platnick & Di Franco, 1992: 8.
Citations (1): Béjaïa: Pic des Singes (Platnick & Di Franco 1992).
Distribution: Algeria (World Spider Catalog 2024).
description: Published as part of Beladjal, Lynda, Bouseksou, Samira, Kherbouche-Abrous, Ourida, Alioua, Youcef & Bosmans, Robert, 2025, First Exhaustive Catalog of Spiders of Algeria (Arachnida: Araneae), pp. 1-185 in Zootaxa 5598 (1) on page 93, DOI: 10.11646/zootaxa.5598.1.1, http://zenodo.org/record/14971861
Supplemental Material - Development and Validation of Algorithms to Predict Activity, Mobility, and Memory Limitations Using Medicare Claims and Post-Acute Care Assessments
Creators: name: Heins, Sara E.
name: Agniel, Denis
name: Mann, Jacob
name: Sorbero, Melony E.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material for Development and Validation of Algorithms to Predict Activity, Mobility, and Memory Limitations Using Medicare Claims and Post-Acute Care Assessments by Sara E. Heins, Denis Agniel, Jacob Mann, and Melony E. Sorbero in Journal of Applied Gerontology
Additional file 1 of Monitoring monocyte HLA-DR expression and CD4 + T lymphocyte count in dexamethasone-treated severe COVID-19 patients
Creators: name: Monneret, Guillaume
name: Voirin, Nicolas
name: Richard, Jean-Christophe
name: Cour, Martin
name: Rimmelé, Thomas
name: Garnier, Lorna
name: Yonis, Hodane
name: Coudereau, Remy
name: Gossez, Morgane
name: Malcus, Christophe
name: Wallet, Florent
name: Delignette, Marie-Charlotte
name: Dailler, Frederic
name: Buisson, Marielle
name: Argaud, Laurent
name: Lukaszewicz, Anne-Claire
name: Venet, Fabienne
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary material 1.
Apertura de las colecciones digitales a través de los Proyectos de la Fundación Wikimedia, presentación
Creators: name: Murrieta, Aidee
name: Gutiérrez De la Torre, Silvia
Publisher: name: Zenodo
Year: 2018
Subjects: Wikipedia
Bibliotecas
Bibliotecas Académicas

description: Presentación del taller ofrecido en SALALM y co-organizado entre la Biblioteca Daniel Cosío Villegas y el grupo de interés de Investigación Digital para América Latina (DíScola).

El orden de la clase puede encontrarse en:

https://doi.org/10.5281/zenodo.1306891
title: Sacred Symbols and Modern Narratives: Applying Rhetorical Analysis to Pop Culture References to Religion
title: Exploring the Intersection of Faith and Media through Rhetorical Frameworks
titleType: Subtitle
Creators: name: Kallol, Chakrabarti
Publisher: name: Zenodo
Year: 2024

description:     The interplay between sacred symbols and modern narratives is a compelling avenue of inquiry for scholars examining the influence of religion within contemporary media. In an era where visual and auditory stimuli permeate everyday life, the rhetorical deployment of religious symbols within popular culture often shapes societal beliefs and cultural perceptions in significant, sometimes unrecognized, ways. Analyzing the complex layering of these symbols in various media forms—such as film, music, and television—illuminates not only the contextual specificities of spiritual imagery but also the broader implications of such representations on public consciousness.
Additional file 1 of Discovering patterns in outpatient neurology appointments using state sequence analysis
Creators: name: Biggin, Fran
name: Ashcroft, Quinta
name: Howcroft, Timothy
name: Knight, Jo
name: Emsley, Hedley
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Evolutionary Biology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 1: Supplemental Table 1. Patient characteristics for the 5 clusters resulting from SSA on the sequences focussed on appointment timing. Chi-square tests were carried out to test for significance and statistically significant p-values are highlighted in bold (Bonferroni adjustments for multiple testing were used). Supplemental Figure 1. Visualisation of the 5 clusters resulting from SSA on the sequences focussed on appointment timing. The most common sequence in each cluster is oriented at the base of the y-axis and the height of the bars represents the frequency of that sequence within the cluster. Cluster size is included in brackets in the y-axis title.
54977: Lochnagar Shell Crater
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: View from within, showing side of crater and cross.
UrbanHistory4D - e22_7ccb3losf
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building in its state since 1990-01-01.The following files are available:Models: 2020-rathausgasse_1_1Surface_Color_lr.glb | 2020-rathausgasse_1_1Surface_Color.glb | 2020-rathausgasse_1_1Surface_Color_nelr.glb | 2020-rathausgasse_1_1Surface_Color_ne.glbMetadata: e22_7ccb3losf.jsonOriginal Files: 2020-rathausgasse_1_1Surface_Color.zipThumbnails: 2020-rathausgasse_1_1Surface_Color_perspective_1.png | 2020-rathausgasse_1_1Surface_Color_perspective_2.png | 2020-rathausgasse_1_1Surface_Color_perspective_3.png | 2020-rathausgasse_1_1Surface_Color_perspective_4.pngEDM-XMLs: e22_7ccb3losf_edm.xmlMets/Mods-XMLs: e22_7ccb3losf_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
sj-docx-2-asm-10.1177_10731911231157629 – Supplemental material for Social Determinants of Health: Associations Between Dichotomous Versus Dimensional Scores, Neuropsychological Test Performance, and Psychiatric Symptoms
Creators: name: Shields, Allison N.
name: Chang, Fini
name: DeBoer, Adam B.
name: Ka Yin Tse, Phoebe
name: Wisinger, Amanda M.
name: Basurto, Karen S.
name: Bing-Canar, Hanaan
name: Khan, Humza
name: Lapitan-Moore, Franchezka
name: Stocks, Jane K.
name: Pliskin, Neil H.
name: Song, Woojin
name: Soble, Jason R.
name: Resch, Zachary J.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-2-asm-10.1177_10731911231157629 for Social Determinants of Health: Associations Between Dichotomous Versus Dimensional Scores, Neuropsychological Test Performance, and Psychiatric Symptoms by Allison N. Shields, Fini Chang, Adam B. DeBoer, Phoebe Ka Yin Tse, Amanda M. Wisinger, Karen S. Basurto, Hanaan Bing-Canar, Humza Khan, Franchezka Lapitan-Moore, Jane K. Stocks, Neil H. Pliskin, Woojin Song, Jason R. Soble and Zachary J. Resch in Assessment
Identify and explore use cases for HMC's (meta)data landscape dataset and the generic Information Portal
Creators: name: Kulla, Lucas
name: Kubin, Markus
Publisher: name: Zenodo
Year: 2024

description: These slides were presented during a workshop held within the “HMC Dialogue” series, hosted by the Helmholtz Metadata Collaboration.

The goal of this hands-on workshop was to identify and explore promising use cases for two HMC products, the Helmholtz (meta)data landscape dataset and the generic Information Portal. 

The workshop was introduced by overview presentations about these two HMC products, followed by brainstorming sessions and a discussion to collect promising use cases.
Cybaeodes liocraninus
Creators: name: Beladjal, Lynda
name: Bouseksou, Samira
name: Kherbouche-Abrous, Ourida
name: Alioua, Youcef
name: Bosmans, Robert
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Liocranidae
Cybaeodes
Cybaeodes liocraninus

description: 9. Cybaeodes liocraninus (Simon, 1913)
Brachyannillus liocraninus Simon, 1913: 378.
Cybaeodes liocraninus; Fage 1931: 209; Bosselaers 2009: 46.
Citations (1): Oran: Misserghin (Simon 1913; Fage 1931; Bosselaers 2009).
Distribution: Algeria (World Spider Catalog 2024).
description: Published as part of Beladjal, Lynda, Bouseksou, Samira, Kherbouche-Abrous, Ourida, Alioua, Youcef & Bosmans, Robert, 2025, First Exhaustive Catalog of Spiders of Algeria (Arachnida: Araneae), pp. 1-185 in Zootaxa 5598 (1) on page 93, DOI: 10.11646/zootaxa.5598.1.1, http://zenodo.org/record/14971861
Edeltraud Gruber: Deutschordensschwestern im 19. und 20. Jahrhundert
Creators: name: Lissek, Thomas
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 1/2 (1975): Römische Quartalschrift, Band 70, Heft 1/2
Eine Bischofspromotion im Zeichen staatskirchlicher Konflikte 1870
Creators: name: Litzenburger, Ludwig
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 1/2 (1975): Römische Quartalschrift, Band 70, Heft 1/2
PLAY THE BALL WITH YOUR COGNITIVE RESOURCES , STICK THE LANDING WITHOUT ANXIETY. A Study on Cognition and Emotions in Youth Volley Ball Players and Artistic Gymnasts
Creators: name: BISAGNO, ELISA
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: This study aims to address two shortcomings in sport psychology research: the scarcity of cognitive
and developmental psychology studies in sports (Furley & Wood, 2016), and the lack of an integrated
approach, i.e. comprising both cognition and emotion, to study sports performance. The aim of this
research is to examine the role of general cognitive abilities, attentional style and emotions in
predicting performance in different sports, namely volleyball and artistic gymnastics.
We tested 218 youth participants (104 artistic gymnasts and 114 volleyball players, aged between 11
and 17 years) with different measures of working memory capacity and executive functions (i.e.
updating, shifting and inhibition). They completed two self-report measures, a Test of Attentional and
Interpersonal Style and a questionnaire on the emotions experienced before a competition. For each
participant, we collected the age and years of experience. The scores collected in 2017 competitions
were the artistic gymnasts? performance measures. For each volleyball player, we computed an
individual performance index, by asking two independent judges to rate their video-recorded
performances in 2017-18 competitions. Then we derived, from our measures, ten predictors, namely a
working memory-updating factor, an inhibition-shifting factor, four attentional style indicators and
four groups of emotional states derived from the crossing of two dimensions, specifically the arousal
(high activation or low activation) and the hedonic tone (pleasant or unpleasant). The regression
analyses pointed to a clear dissociation. On the one hand, the working memory-updating factor was
the only predictor (together with the experience) of the volleyball players? performance, with a
moderation effect of emotional arousal on this relationship. On the other hand, experience and higharousal
unpleasant emotions (the latter with a negative coefficient) were the only predictors of artistic
gymnasts? performance. This evidence underlines how performance in open-skills sports (volleyball),
where athletes need to process a significant amount of information, mainly depends on working
memory, while in closed-skills sports (artistic gymnastics), where gestures are highly automatized, it
is affected by emotion regulation. Further differences between the sports sample are also described in
the dissertation.
UrbanHistory4D - e22_Ex3WMBn4R
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building in its state since 1990-01-01.The following files are available:Models: 2020-jentower_lr.glb | 2020-jentower.glb | 2020-jentower_nelr.glb | 2020-jentower_ne.glbMetadata: e22_Ex3WMBn4R.jsonOriginal Files: 2020-jentower.zipThumbnails: 2020-jentower_perspective_1.png | 2020-jentower_perspective_2.png | 2020-jentower_perspective_3.png | 2020-jentower_perspective_4.pngEDM-XMLs: e22_Ex3WMBn4R_edm.xmlMets/Mods-XMLs: e22_Ex3WMBn4R_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Bioactive molecules isolated from olive pomace extract protect murine cortex neurons from NMDA-mediated cell death
Creators: name: FRANCHI, ALICE
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Changes in intracellular calcium concentration are crucial events during signal transduction processes involved in several cellular physiological functions. Moreover, even a limited dysregulation in intracellular calcium homeostasis can promotes the onset and the progression of neuropathological processes. We have shown previously that the olive pomace extract, obtained in condition of high pressure and high temperature (HPTE), contains bioactive molecules able to prevent calcium-induced cell damages on human neuroblastoma (SK-N-BE) and mouse brain endothelioma (bEnd5) cell lines, operating through the regulation of the cell dynamics that involve the calcium ions. In this thesis, we report the effect of HPTE on primary cell culture of murine cortical neurons used as a cellular model. Specifically, in order to induce a cytotoxic influx of Ca2+ through the opening of the NMDA (N-Methyl-D-Aspartic-Acid) receptor (NMDAR), we treated neurons with NMDA in the presence or in the absence of HPTE for 24 hours. We demonstrate that HPTE 1) significantly reduces the cytotoxic effect of NMDA, evaluated as percentage of cell death, and 2) operates preventing the increase of the intracellular calcium concentration mediated by the NMDAR. To identify the chemical nature of the active factors in the olive pomace extract, we have fractionated HPTE by RP-HPLC, followed by the assay of the cell protective effect. Successively, on the fractions containing the bioactivity and using mass spectrometry techniques, we established that the relevant molecules could be derivatives of the epigallocatechin or of the loganin. The ultimate aim of this work is to provide new information about the structural and functional specificity of molecules present in the HPTE in order to propose new possible strategies for therapeutic interventions in neurodegenerative diseases.
All-natural polymer composites with engineered properties
Creators: name: TEDESCHI, GIACOMO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: In the last decades, petroleum-based synthetic polymers have been widely used for the production of plastic materials thanks to their versatile and multifunctional properties. Nevertheless, the environmental problems related to their total inability to biodegrade and the release of toxic chemical with time are pushing researchers to exploit natural polymers from bioresources as building blocks to fabricate plastic-like materials. Methods for the extraction of natural polymers from plants, animals, and microorganism have already been proposed in literature, but these natural compounds still present weaknesses related to their mechanical and optical properties, humidity resistance, and barrier properties.
The aim of this Thesis is the design and the development of all-natural polymer composites combining the properties of various natural polymers both as matrix and as nano-micro fillers in just one combined material. A detailed analysis about the proper modification of the initial structure will be given, with emphasis on the tuning of the final properties. The production methods used in this work are compatible with processes, such as casting, extrusion, and hot-pressing, used in plastics processing industry in order to develop natural composite materials that can be easily scalable. Moreover, a comprehensive comparison of these novel natural composites with respect to commonly used synthetic materials is shown.
After a general introduction about the economy and the main advantages and drawbacks of petroleum-based plastics, a meticulous review of the main biopolymers used as sustainable alternatives to their synthetic counterparts and a description of the main advantages of natural polymeric composites is discussed. Other additional Chapters form this Thesis:
1. The first one is about the functionalization of cellulose acetate with oleic acid.
2. The second one is focused on the amorphous reassembly of the three main components of wood, i.e. cellulose, hemicellulose and lignin.
3. The third one presents the fabrication of biocomposites from aleuritic acid and nanocellulose.
4. The fourth one is related with the reinforcement of fibrous composite mycelium with a polyaleuritate coating.
5. The fifth one describes the fabrication of plant cuticle-like packaging films from tomato pomace agro-waste, beeswax, and sodium alginate.
UrbanHistory4D - e22_KXHk2OuO2
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building in its state since 1990-01-01.The following files are available:Models: 2020-markt_6_1Surface_Color_lr.glb | 2020-markt_6_1Surface_Color.glb | 2020-markt_6_1Surface_Color_nelr.glb | 2020-markt_6_1Surface_Color_ne.glbMetadata: e22_KXHk2OuO2.jsonOriginal Files: 2020-markt_6_1Surface_Color.zipThumbnails: 2020-markt_6_1Surface_Color_perspective_1.png | 2020-markt_6_1Surface_Color_perspective_2.png | 2020-markt_6_1Surface_Color_perspective_3.png | 2020-markt_6_1Surface_Color_perspective_4.pngEDM-XMLs: e22_KXHk2OuO2_edm.xmlMets/Mods-XMLs: e22_KXHk2OuO2_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Rapports entre Augustiniens et Dominicains portugais avec les Dominicains arméniens au XVII siècle
Creators: name: Gulbenkian, Roberto
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 70 Nr. 1/2 (1975): Römische Quartalschrift, Band 70, Heft 1/2
Status of the Engineering Design of the IFMIF-DONES High Energy Beam Transport Line and Beam Dump System
Creators: name: Sánchez-Herranz, D.
name: Arranz, F.
name: Cara, P.
name: Hauer, V.
name: Nomen, O.
name: Ogando, F.
name: Oliver, C.
name: Podadera, I.
name: Sanmartí, M.
name: Singh, B. K.
Publisher: name: JACoW Publishing
Year: 2022

description: IFMIF-DONES plant (In­ter­na­tional Fu­sion Ma­te­ri­als Ir­ra­di­a­tion Fa­cil­ity ’ DEMO Ori­ented Neu­tron Source) will be an in­stal­la­tion lo­cated in the south of Spain at Granada. Its ob­jec­tive is the fu­sion ma­te­r­ial test­ing by the gen­er­a­tion of a neu­tron flux with a broad en­ergy dis­tri­b­u­tion cov­er­ing the typ­i­cal neu­tron spec­trum of a (D-T) fu­sion re­ac­tor. This is achieved by the Li(d, xn) nu­clear re­ac­tions oc­cur­ring in a liq­uid lithium tar­get where a 40 MeV at 125 mA deuteron beam with a vari­able rec­tan­gu­lar beam foot­print be­tween 100mm x 50mm and 200mm x 50mm col­lides. The ac­cel­er­a­tor sys­tem is in charge of pro­vid­ing such high en­ergy deuterons in order to pro­duce the re­quired neu­tron flux. The High En­ergy Beam Trans­port line is the last sub­sys­tem of the IFMIF-DONES ac­cel­er­a­tor and its main func­tions are to guide the deuteron beam to­wards the liq­uid lithium tar­get and to shape it with the re­quired rec­tan­gu­lar ref­er­ence beam foot­print. The pre­sent work de­tails the sta­tus of the HEBT en­gi­neer­ing de­sign, in­clud­ing beam dy­nam­ics, vac­uum con­fig­u­ra­tion, ra­dio­pro­tec­tion, beam di­ag­nos­tics de­vices and re­mote han­dling analy­ses per­formed de­tail­ing the lay­out and in­te­gra­tion.