cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays
Creators: name: Liu, Li
name: Davis, Mindy I.
name: Cheff, Dorian M.
name: Shah, Pranav
name: Wang, Amy
name: Simeonov, Anton
name: Titus, Steven A.
name: Xu, Xin
name: Lee, Tobie D.
name: Shen, Min
name: Brimacombe, Kyle R.
name: Henderson, Mark J.
name: Boxer, Matthew B.
name: Fang, Yuhong
name: Pragani, Rajan
name: Rohde, Jason M.
name: McIver, Andrew
name: Karavadhi, Surendra
name: Wang, Xiaodong
name: Lee, Olivia W.
name: Martinez, Natalia J.
name: Urban, Daniel J.
name: Hall, Matthew D.
name: Zheng, Hongchao
name: Jadhav, Ajit
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that are mutated in a variety of cancers to confer a gain-of-function activity resulting in the accumulation and secretion of an oncometabolite, D-2-hydroxyglutarate (2-HG). Accumulation of 2-HG can result in epigenetic dysregulation and a block in cellular differentiation, suggesting these mutations play a role in neoplasia. Based on its potential as a cancer target, a number of small molecule inhibitors have been developed to specifically inhibit mutant forms of IDH (mIDH1 and mIDH2). Here, a panel of mIDH inhibitors were systematically profiled using biochemical, cell-based, and tier-one ADME techniques. We quantified the biochemical effect of each inhibitor on mIDH1 (R132H and R132C) and mIDH2 (R172Q). The effect of these inhibitors on 2-HG concentrations in seven cell lines representing five different IDH1 mutations in both 2D and 3D cell cultures was assessed. Target engagement of these inhibitors was analyzed utilizing cellular thermal shift assays (CETSA), the effects of inhibitors on reversing 2- HG-induced block on leukemic cellular differentiation. We conclude from our mIDH1 assay panel that AG-120 and a Novartis inhibitor exhibited excellent activity in all biochemical and most cellular assays. While AG-120 has superior DMPK properties, it lacks efficacy a leukemic differentiation model. In conclusion, we present a comprehensive suite of in vitro preclinical drug development assays that can be used as a tool-box to identify lead compounds for mIDH drug discovery programs, as well as what we believe is the most comprehensive publically available dataset on the top mIDH inhibitors.
The Capillaries of Power: Hierarchy and Servitude in the Story of the Stone
Creators: Lupke, Christopher
Publisher: name: University of Alberta Library
Year: 2012

This essay analyzes several of the maids depicted in The Story of the Stone (Dream of the Red Chamber), demonstrating how through their behavior and what they say they actually reinforce the social hierarchy and status quo that underlie the social reality of Qing dynasty China. It highlights the representation of three key maids in the novel: Aroma, Patience, and Faithful. Each in her own way asserts her own personality and demonstrates how adherence to hierarchy is critical to harmony in the household and broader society. The essay then goes on to briefly mention the cases of some of the less prominent maids, such as Nightingale, Snowgoose, and Skybright. Ambiguous characters such as Caltrop, of "lost" scholar-gentry origin, and Er-jie, a woman who though not a maid is nonetheless abused in the novel, lend complexity to this sprawling Qing dynasty saga. The essay ends by illustrating that Tan-chun, half-sister to two of the main characters but the daughter of a former chamber maid, can both be elevated to the status of the social elite while remaining somewhat vulnerable to the vagaries of social hierarchy.
Unraveling the connection between high-order magnetic interactions and local-to-global spin Hamiltonian in non-collinear magnetic dimers
Creators: name: Cardias, Ramon
name: Silva, Jhonatan dos Santos
name: Bergman, Anders
name: Szilva, Attila
name: Kvashnin, Yaroslav O.
name: Fransson, Jonas
name: Klautau, Angela B.
name: Eriksson, Olle
name: Delin, Anna
name: Nordström, Lars
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A spin Hamiltonian, which characterizes interatomic interactions between spin moments, is highly valuable in predicting and comprehending the magnetic properties of materials. A deeper understanding of the microscopic origin of magnetic interactions can open new pathways toward realizing nanometer-scale systems for future spintronic devices. Here, we explore a method for explicitly calculating interatomic exchange interactions in non-collinear configurations of magnetic materials considering only a bilinear spin Hamiltonian in a local scenario. Based on density-functional theory (DFT) calculations of dimers adsorbed on metallic surfaces, and with a focus on the Dzyaloshinskii-Moriya interaction (DMI) which is essential for stabilizing chiral non-collinear magnetic states, we discuss the interpretation of the DMI when decomposed into microscopic electron and spin densities and currents. We clarify the distinct origins of spin currents induced in the system and their connection to the DMI. In addition, we reveal how non-collinearity affects the usual DMI, which is solely induced by spin-orbit coupling, and DMI-like interactions brought about by non-collinearity. We explain how the dependence of the DMI on the magnetic configuration establishes a connection between high-order magnetic interactions, enabling the transition from a local to a global spin Hamiltonian.
description: 11 pages, 3 figures
Problems with using separated variables for computing expectation values for higher ranks
Creators: name: Martin, D.
name: Smirnov, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider the simplest classical integrable model corresponding to a non-hyperelliptic spectral curve. We show that a certain complicated integral occurs when computing the average of observables in this model. This integral does not factorise. Since similar problems should also exist in the quantum case, we think that a serious question arises of how to deal with these integrals.
description: 15 pages, acknowledgement added
Innerkirchlicher Pluralismus und Freiheit in der modernen Gesellschaft
Creators: name: Bolado Alvarez, Ildefons
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 5 Nr. 3 (1969): Concilium: Internationale Zeitschrift für Theologie, Band 5, Heft 3
A Marcusean Look at Rationality, Structural Crises, and the Eros Effect
Creators: name: Russo, Daniel
Publisher: name: figshare
Year: 2023
Subjects: Political theory and political philosophy

description: Under capitalist modernity, we struggle with the effects of rationality, or at least a certain kind of it. On the one hand, this rationality often gets limited to base mathematico-empiricism, and we lose sight of history, of the potential of a fully different world. We use rational techniques to put band-aids on various wounds, but we lose sight of the possibility of transforming the body. Then, on the other hand, through this surface-level rationalism as well as from experiencing the general conditions of (capitalist) modernity, we have pent up (surplus) aggressiveness, from the repression of potential. This sets a condition of possibility for the spontaneous release of energy, such as found in moments of snowball-effect strikes and protests, from local to intercontinental. However, these same energies can be co-opted by fascism, as both socialist/futurist and fascist revolutionary politics rely on populist logics. And this matters most in moments of structural crises, in moments of crises of capital accumulation that lead to system reconfiguration in order to avoid system collapse. These are restructuring moments, the moment where we naturally have surplus aggressiveness against the system and, at the same time, the moment where its most opportune for capture.
Clocked dynamics in artificial spin ice
Creators: name: Jensen, Johannes H.
name: Strømberg, Anders
name: Breivik, Ida
name: Penty, Arthur
name: Foerster, Michael
name: Niño, Miguel Angel
name: Khaliq, Muhammad Waqas
name: Tufte, Gunnar
name: Folven, Erik
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Artificial spin ice (ASI) are nanomagnetic metamaterials exhibiting a wide range of emergent properties, which have recently shown promise for neuromorphic computing. However, the lack of efficient protocols to control the state evolution of these metamaterials has been limiting progress. To overcome this barrier, we introduce astroid clocking, a global field protocol offering discrete, gradual evolution of spin states. The method exploits the intrinsic switching astroids and dipolar interactions of the nanomagnets to selectively address ASI spins in sequence. We demonstrate, experimentally and in simulations, how astroid clocking of pinwheel ASI allows ferromagnetic domains to be gradually grown or reversed at will. More complex dynamics arise when the clock protocol allows both growth and reversal to occur simultaneously. Astroid clocking offers unprecedented control and understanding of ASI dynamics in both time and space, extending what is possible in nanomagnetic metamaterials.
Josephson phase diffusion in the SQUID ratchet
Creators: name: Spiechowicz, Jakub
name: Łuczka, Jerzy
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences
subject: 60J60

description: We study diffusion of the Josephson phase in the asymmetric SQUID subjected to a time-periodic current and pierced by an external magnetic flux. We analyze a relation between phase diffusion and quality of transport characterized by the dc voltage across the SQUID and efficiency of the device. In doing so, we concentrate on the previously reported regime [J. Spiechowicz and J. Łuczka, New J. Phys. \textbf{17}, 023054 (2015)] for which efficiency of the SQUID attains a global maximum. For long times, the mean-square displacement of the phase is a linear function of time, meaning that diffusion is normal. Its coefficient is small indicating rather regular phase evolution. However, it can be magnified \emph{several times} by tailoring experimentally accessible parameters like amplitudes of the ac current or external magnetic flux. Finally, we prove that in the deterministic limit this regime is essentially \emph{non-chaotic} and possesses an unexpected simplicity of attractors.
description: in press in Chaos: An Interdisciplinary Journal of Nonlinear Science
Dynamics and Phases of Nonunitary Floquet Transverse-Field Ising Model
Creators: name: Su, Lei
name: Clerk, Aashish
name: Martin, Ivar
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Inspired by current research on measurement-induced quantum phase transitions, we analyze the nonunitary Floquet transverse-field Ising model with complex nearest-neighbor couplings and complex transverse fields. Unlike its unitary counterpart, the model shows a number of steady phases, stable to integrability breaking perturbations. Some phases have robust edge modes and/or spatiotemporal long-range orders in the bulk. The transitions between the phases have extensive entanglement entropy, whose scaling with the system size depends on the number of the real quasiparticle modes in the spectrum at the transition. In particular, the volume law scaling appears on some critical lines, protected by pseudo-Hermiticity. Both the scaling of entanglement entropy in steady states and the evolution after a quench are compatible with the non-Hermitian generalization of the quasiparticle picture of Calabrese and Cardy at least qualitatively.
description: 15 pages, 14 figures; v2, references added; v3, published version
Der Diözesanklerus und die Ordensgesellschaften und Säkularinstitute
Creators: name: Andreu-Rodrigo, Augustin
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 5 Nr. 3 (1969): Concilium: Internationale Zeitschrift für Theologie, Band 5, Heft 3
Novel Dynamics and Thermodynamics in systems with long range interactions
Creators: name: Atenas, Boris
name: Curilef, Sergio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Systems with long range interactions display some anomalies when its dynamics and thermodynamics are studied below certain conditions. Among these anomalies are the quasi- stationary states, which are exacerbated because of special initial conditions that are used here. We present in this letter a new Hamiltonian whose potential is inspired in the two-dipole interaction. An analytical solution is obtained for the equilibrium in the canonical ensemble that is coincident with the one obtained from computational simulations. However, results from this model presents a kind of nonequivalence of ensembles in long-living states before arriving to equilibrium. Thus, a complete characterization is made for the nonequilibrium through molecular dynamics. In which, novel quasi-stationary states are observed due to the long range interactions.
Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell–Renal-Cell-Carcinoma: Proof-of-Concept Study
Creators: name: Brooks, Samira A.
name: Woods, Michael E.
name: Hung, Sheng-Che
name: Shen, Dinggang
name: Yin, Qingbo
name: Fielding, Julia R.
name: Wang, Li
name: Khandani, Amir H.
name: Rathmell, W. Kimryn
name: Milowsky, Matthew I.
name: Lin, Weili
name: Wallen, Eric. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Studies have shown that tumor angiogenesis is an essential process for tumor growth, proliferation and metastasis. Also, tumor angiogenesis is an important prognostic factor of clear cell renal cell carcinoma (ccRCC), as well as a factor in guiding treatment with antiangiogenic agents. Here, we attempted to find the associations between tumor angiogenesis and radiomic imaging features from PET/MRI. Specifically, sparse canonical correlation analysis was conducted on 3 feature datasets (i.e., radiomic imaging features, tumor microvascular density (MVD), and vascular endothelial growth factor (VEGF) expression) from 9 patients with primary ccRCC. In order to overcome the potential bias of intratumoral heterogeneity of angiogenesis, this study investigated the relationship between regional expressions of angiogenesis and VEGF, and localized radiomic features from different parts within the tumors. Our study highlighted the significant strong correlations between radiomic features and MVD, and also demonstrated that the spatiotemporal features extracted from DCE-MRI provided stronger radiomic correlation to MVD than the textural features extracted from Dixon sequences and FDG PET. Furthermore, PET/MRI, which takes advantage of the combined functional and structural information, had higher radiomics correlation to MVD than solely utilizing PET or MRI alone.
Theoretical study of phase behaviour of DLVO model for lysozyme and $γ$-crystalline aqueous electrolyte solutions
Creators: name: Melnyk, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Mean spherical approximation (MSA), second-order Barker-Henderson (BH) perturbation theory and thermodynamic perturbation theory (TPT) for associating fluids in combination with BH perturbation theory are applied to the study of the structural properties and phase behaviour of the Derjaguin-Landau-Verwey-Overbeek (DLVO) model of lysozyme and $γ$-cristalline aqueous electrolyte solutions. Predictions of the MSA for the structure factors are in good agreement with the corresponding computer simulation predictions. The agreement between theoretical results for the liquid-gas phase diagram and the corresponding results of the experiment and computer simulation is less satisfactory, with predictions of the combined BH-TPT approach being the most accurate.
description: 9 pages, 3 figures
Asymmetric Waveforms Decrease Lethal Thresholds in High Frequency Irreversible Electroporation Therapies
Creators: name: Sano, Michael B.
name: Xing, Lei
name: Fan, Richard E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Irreversible electroporation (IRE) is a promising non-thermal treatment for inoperable tumors which uses short (50–100 μs) high voltage monopolar pulses to disrupt the membranes of cells within a well-defined volume. Challenges with IRE include complex treatment planning and the induction of intense muscle contractions. High frequency IRE (H-FIRE) uses bursts of ultrashort (0.25–5 μs) alternating polarity pulses to produce more predictable ablations and alleviate muscle contractions associated with IRE. However, H-FIRE generally ablates smaller volumes of tissue than IRE. This study shows that asymmetric H-FIRE waveforms can be used to create ablation volumes equivalent to standard IRE treatments. Lethal thresholds (LT) of 505 V/cm and 1316 V/cm were found for brain cancer cells when 100 μs IRE and 2 μs symmetric H-FIRE waveforms were used. In contrast, LT as low as 536 V/cm were found for 2 μs asymmetric H-FIRE waveforms. Reversible electroporation thresholds were 54% lower than LTs for symmetric waveforms and 33% lower for asymmetric waveforms indicating that waveform symmetry can be used to tune the relative sizes of reversible and irreversible ablation zones. Numerical simulations predicted that asymmetric H-FIRE waveforms are capable of producing ablation volumes which were 5.8–6.3x larger than symmetric H-FIRE waveforms indicating that in vivo investigation of asymmetric waveforms is warranted.
title: Stellenwert der MRT/TRUS Fusionsbiopsie mit dem Koelis Trinity ® System für die Detektion klinisch signifikanter Prostatakarzinome im Rahmen der Primär- und Re-Biopsie
Creators: name: Mangold, Alexander
name: Brummeisl, Wolfgang
name: Siokou, Fiona-Sofia
name: Ganzer, Roman
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die MRT/TRUS Fusionsbiopsie nimmt einen wachsenden Stellenwert bei der Prostatakarzinomdiagnostik ein. Das Trinity® (Koelis, Frankreich) ist ein kompaktes all-in-one Gerät, zu dem bislang kaum publizierte Ergebnisse vorliegen. Wir untersuchten den Stellenwert der Fusionsbiopsie[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Activity-based model developments for emerging mobility and its applications
Creators: name: TRI, NGUYEN KY
Publisher: name: Monash University
Year: 2022
Subjects: Transport planning
Optimisation
Civil engineering not elsewhere classified

description: In this dissertation, we focus on developing activity-based frameworks to model future mobilities (e.g., car-sharing) to study their characteristics and evaluate their impacts on travellers' behaviors using the activity-based modelling (ABM) approach. Besides, we also leverage the ABM approach to further apply it to the non-transport domain to examine the impact of transport-related policies on Coronavirus 2019 (COVID-19) pandemic modelling.
Der Einsatz der Priester in der territorialen und nichtterritorialen Seelsorge
Creators: name: Greinacher, Norbert
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 5 Nr. 3 (1969): Concilium: Internationale Zeitschrift für Theologie, Band 5, Heft 3
Boosting the annihilation boost: Tidal effects on dark matter subhalos and consistent luminosity modeling
Creators: name: Bartels, Richard
name: Ando, Shin'ichiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In the cold dark matter paradigm, structures form hierarchically, implying that large structures contain smaller substructures. These subhalos will enhance signatures of dark matter annihilation such as gamma rays. In the literature, typical estimates of this boost factor assume a concentration-mass relation for field halos, to calculate the luminosity of subhalos. However, since subhalos accreted in the gravitational potential of their host loose mass through tidal stripping and dynamical friction, they have a quite characteristic density profile, different from that of the field halos of the same mass. In this work, we quantify the effect of tidal stripping on the boost factor, by developing a semi-analytic model that combines mass-accretion history of both the host and subhalos as well as subhalo accretion rates. We find that when subhalo luminosities are treated consistently, the boost factor increases by a factor 2-5, compared to the typical calculation assuming a field-halo concentration. This holds for host halos ranging from sub-galaxy to cluster masses and is independent of the subhalo mass function or specific concentration-mass relation. The results are particularly relevant for indirect dark matter searches in the extragalactic gamma-ray sky.
description: 9 pages, 5 figures, 1 table. Accepted for publication in PRD
Calcifying algae maintain settlement cues to larval abalone following algal exposure to extreme ocean acidification
Creators: name: Potts, Donald C.
name: Rogers-Bennett, Laura
name: O'Leary, Jennifer K.
name: Barry, James P.
name: Gabrielson, Paul W.
name: Palumbi, Stephen R.
name: Micheli, Fiorenza
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Ocean acidification (OA) increasingly threatens marine systems, and is especially harmful to calcifying organisms. One important question is whether OA will alter species interactions. Crustose coralline algae (CCA) provide space and chemical cues for larval settlement. CCA have shown strongly negative responses to OA in previous studies, including disruption of settlement cues to corals. In California, CCA provide cues for seven species of harvested, threatened, and endangered abalone. We exposed four common CCA genera and a crustose calcifying red algae, Peyssonnelia (collectively CCRA) from California to three pCO levels ranging from 419-2,013 µatm for four months. We then evaluated abalone (Haliotis rufescens) settlement under ambient conditions among the CCRA and non-algal controls that had been previously exposed to the pCO treatments. Abalone settlement and metamorphosis increased from 11% in the absence of CCRA to 45-69% when CCRA were present, with minor variation among CCRA genera. Though all CCRA genera reduced growth during exposure to increased pCO , abalone settlement was unaffected by prior CCRA exposure to increased pCO . Thus, we find no impacts of OA exposure history on CCRA provision of settlement cues. Additionally, there appears to be functional redundancy in genera of CCRA providing cues to abalone, which may further buffer OA effects.
title: Wertigkeit der multiparametrischen MRT in Kombination mit einer Fusionsbiopsie im Rahmen einer Erst- und Re-Biopsie der Prostata
Creators: name: Schauer, Ingrid
name: Krammer, Christa
name: Klinda, Bernhard
name: Horvath-Mechtler, Barbara
name: Madersbacher, Stephan
name: Stoces, Ursula
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einführung: Wir berichten über unsere Erfahrung mit der multiparametrischen MRT (mpMRT) in Kombination mit einer transrektal-ultraschallgeführten Fusionsbiopsie bei der Detektion des Prostatakarzinoms (PKa). Methodik: Patienten, die zu einer Erst- oder Re-Biopsie der Prostata zugewiesen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Vita Communis: Verbindungen, Gemeinschaften und Gemeinschaftsformen der Weltpriester
Creators: name: Bareła, Stefan
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 5 Nr. 3 (1969): Concilium: Internationale Zeitschrift für Theologie, Band 5, Heft 3
On various integrable discretisations of a general two component Volterra system
Creators: name: Babalic, Nicoleta-Corina
name: Carstea, A. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We present two integrable discretisations of a general differential-difference bicomponent Volterra system. The results are obtained by discretising directly the corresponding Hirota bilinear equations in two different ways. Multisoliton solutions are presented together with a new discrete form of Lotka-Volterra equation obtained by an alternative bilinearisation.
description: 14 pages, 2 figures
title: Zufallsbefunde im multiparametrischen 3.0 Tesla-MRT der Prostata und ihre Auswirkung auf das weitere Tumormanagement
Creators: name: Doblhammer, Stephan
name: Kinger, Paul
name: Kastenberger, Reinhard
name: Schmidt, Stefan
name: Kivaranovic, Danijel
name: Susani, Martin
name: Eisenhuber-Stadler, Edith
name: Brössner, Clemens
name: Schima, Wolfgang
name: Friedl, Alexander
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Das multiparametrische MRT (mpMRT) der Prostata erhielt in der Prostatakarzinom (PCa) Detektion einen neuen Stellenwert und wird zunehmend in der Primärdiagnostik eingesetzt. Durch den vermehrten Einsatz desselben werden urologische und nicht-urologische Zufallsbefunde (ZB) festgestellt,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Candidate regulators of Early Leaf Development in Maize Perturb Hormone Signalling and Secondary Cell Wall Formation When Constitutively Expressed in Rice
Creators: name: Rizal, Govinda
name: Schuler, Mara L.
name: Yin, Xiaojia
name: Quick, W. Paul
name: Hughes, Tom
name: Sedelnikova, Olga
name: Lo, Shuen-Fang
name: Fouracre, Jim P.
name: Langdale, Jane A.
name: Wang, Peng
name: Dionora, Mary Jacqueline
name: Jamous, Basel Abu
name: Biswal, Akshaya K.
name: Bandyopadhyay, Anindya
name: Kelly, Steven
name: Yu, Su-May
name: Karki, Shanta
name: Lin, Hsiang-Chun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: All grass leaves are strap-shaped with a series of parallel veins running from base to tip, but the distance between each pair of veins, and the cell-types that develop between them, differs depending on whether the plant performs C or C photosynthesis. As part of a multinational effort to introduce C traits into rice to boost crop yield, candidate regulators of C leaf anatomy were previously identified through an analysis of maize leaf transcriptomes. Here we tested the potential of 60 of those candidate genes to alter leaf anatomy in rice. In each case, transgenic rice lines were generated in which the maize gene was constitutively expressed. Lines grouped into three phenotypic classes: (1) indistinguishable from wild-type; (2) aberrant shoot and/or root growth indicating possible perturbations to hormone homeostasis; and (3) altered secondary cell wall formation. One of the genes in class 3 defines a novel monocot-specific family. None of the genes were individually sufficient to induce C -like vein patterning or cell-type differentiation in rice. A better understanding of gene function in C plants is now needed to inform more sophisticated engineering attempts to alter leaf anatomy in C plants.
Growth kinetics and substrate stability during high-temperature molecular beam epitaxy of AlN nanowires
Creators: name: John, Philipp
name: Ruiz, Mikel Gómez
name: van Deurzen, Len
name: Lähnemann, Jonas
name: Trampert, Achim
name: Geelhaar, Lutz
name: Brandt, Oliver
name: Auzelle, Thomas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the molecular beam epitaxy of AlN nanowires between 950 and 1215 °C, well above the usual growth temperatures, to identify optimal growth conditions. The nanowires are grown by self-assembly on TiN(111) films sputtered onto Al$_2$O$_3$. Above 1100 °C, the TiN film is seen to undergo grain growth and its surface exhibits {111} facets where AlN nucleation preferentially occurs. Modelling of the nanowire elongation rate measured at different temperatures shows that the Al adatom diffusion length is maximised at 1150 °C, which appears to be the optimum growth temperature. However, analysis of the nanowire luminescence shows a steep increase in the deep-level signal already above 1050 °C, associated with O incorporation from the Al$_2$O$_3$ substrate. Comparison with AlN nanowires grown on Si, MgO and SiC substrates suggests that heavy doping of Si and O by interdiffusion from the TiN/substrate interface increases the nanowire internal quantum efficiency, presumably due to the formation of a SiN$_x$ or AlO$_x$ passivation shell. The outdiffusion of Si and O would also cause the formation of the inversion domains observed in the nanowires. It follows that for optoelectronic and piezoelectric applications, optimal AlN nanowire ensembles should be prepared at 1150 °C on TiN/SiC substrates and will require an ex situ surface passivation.
description: Main Paper: 13 pages, 5 figures; Supporting Information: 4 pages, 4 figures
A novel approach to derive halo-independent limits on dark matter properties
Creators: name: Ferrer, Francesc
name: Ibarra, Alejandro
name: Wild, Sebastian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose a method that allows to place an upper limit on the dark matter elastic scattering cross section with nucleons which is independent of the velocity distribution. Our approach combines null results from direct detection experiments with indirect searches at neutrino telescopes, and goes beyond previous attempts to remove astrophysical uncertainties in that it directly constrains the particle physics properties of the dark matter. The resulting halo-independent upper limits on the scattering cross section of dark matter are remarkably strong and reach $σ_{\text{SI}}^{p} \lesssim 10^{-43} \, (10^{-42})~\text{cm}^2$ and $σ_{\text{SD}}^{p} \lesssim 10^{-37} \, (3\times 10^{-37 })~\text{cm}^2$, for dark matter particles of $m_{\text{DM}}\sim 1~\text{TeV}$ annihilating into $W^+W^-$ ($b\bar b$), assuming $ρ_\text{loc}=0.3\text{ GeV}/\text{cm}^3$.
description: 18 pages, 4 figures. Matches published version
CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1
Creators: name: Choi, Eui-Ju
name: Parise, Leslie V.
name: Yoon, Kyoung Wan
name: Yang, Hyun-Suk
name: Kim, Young Mok
name: Sun, Woong
name: Naik, Ulhas P.
name: Kang, Seongman
name: Kim, Yeonsil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain remains unclear. Here, we show that CIB1 negatively regulates degeneration of dopaminergic neurons in a mouse model of Parkinson's disease using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Genetic deficiency of the CIB1 gene enhances MPTP-induced neurotoxicity in dopaminergic neurons in CIB1-/- mice. Furthermore, RNAi-mediated depletion of CIB1 in primary dopaminergic neurons potentiated 1-methyl-4-phenyl pyrinidium (MPP+)-induced neuronal death. CIB1 physically associated with apoptosis signal-regulating kinase 1 (ASK1) and thereby inhibited the MPP+-induced stimulation of the ASK1-mediated signaling cascade. These findings suggest that CIB1 plays a protective role in MPTP/MPP+-induced neurotoxicity by blocking ASK1-mediated signaling.
Trees Assembling Mann Whitney Approach for Detecting Genome-wide Joint Association among Low Marginal Effect loci
Creators: name: Wei, Changshuai
name: Schaid, Daniel J.
name: Lu, Qing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Computation (stat.CO)
subject: Machine Learning (stat.ML)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Common complex diseases are likely influenced by the interplay of hundreds, or even thousands, of genetic variants. Converging evidence shows that genetic variants with low marginal effects (LME) play an important role in disease development. Despite their potential significance, discovering LME genetic variants and assessing their joint association on high dimensional data (e.g., genome wide association studies) remain a great challenge. To facilitate joint association analysis among a large ensemble of LME genetic variants, we proposed a computationally efficient and powerful approach, which we call Trees Assembling Mann whitney (TAMW). Through simulation studies and an empirical data application, we found that TAMW outperformed multifactor dimensionality reduction (MDR) and the likelihood ratio based Mann whitney approach (LRMW) when the underlying complex disease involves multiple LME loci and their interactions. For instance, in a simulation with 20 interacting LME loci, TAMW attained a higher power (power=0.931) than both MDR (power=0.599) and LRMW (power=0.704). In an empirical study of 29 known Crohn's disease (CD) loci, TAMW also identified a stronger joint association with CD than those detected by MDR and LRMW. Finally, we applied TAMW to Wellcome Trust CD GWAS to conduct a genome wide analysis. The analysis of 459K single nucleotide polymorphisms was completed in 40 hours using parallel computing, and revealed a joint association predisposing to CD (p-value=2.763e-19). Further analysis of the newly discovered association suggested that 13 genes, such as ATG16L1 and LACC1, may play an important role in CD pathophysiological and etiological processes.
Inebilizumab: A Review in Neuromyelitis Optica Spectrum Disorder
Creators: name: Nie, Tina
name: Blair, Hannah A.
Publisher: name: Adis Journals
Year: 2022
Subjects: subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Tina Nie and Hannah Blair are salaried employees of Adis International Ltd/Springer Nature, and declare no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable. Additional information about this Adis Drug Review can be found here. Abstract  Inebilizumab (Uplizna®) is a recently approved monoclonal antibody for use in adults with neuromyelitis optica spectrum disorder (NMOSD) who are anti-aquaporin-4 (AQP4) antibody seropositive. Inebilizumab targets the B cell antigen CD19 and effectively depletes circulating B cells, thus suppressing inflammatory NMOSD attacks that are potentially disabling or life-threatening. It is approved as an intravenous infusion in several countries. In the pivotal phase 2/3 N-MOmentum trial, inebilizumab reduced the risk of NMOSD attacks compared with placebo, including in AQP4-antibody seropositive patients. Inebilizumab also significantly reduced the risk of disability score worsening, the number of NMOSD-related hospitalisations and MRI lesion count, but had no significant effect on low-contrast binocular vision. The treatment effect on relapse risk and disability scores was sustained in inebilizumab-treated patients for ≥ 4 years during the open-label extension. Inebilizumab was generally well tolerated, with the most common adverse events being urinary tract infection and arthralgia. Thus, inebilizumab is an effective treatment option for adults with AQP4-antibody seropositive NMOSD. © Springer Nature Switzerland AG 2022
Robotic art as a vector for techno-critique
Creators: name: Granjon, Paul
Publisher: name: Cardiff Metropolitan University
Year: 2022
Subjects: Fine arts
Performance art
Visual arts not elsewhere classified

description: Through the short history of robotic art, artists have produced non-utilitarian machines that offer cultural comments on our relation with increasingly intelligent artefacts. Robotic art, free from constraints faced by technologists and scientists, allows for a different perspective on this changing relation as well as a critical reflection on technological adoption. The present analysis traces the development of my practice-based research in robotic art. I show how the practice aims at disseminating a critique of technics, specifically raising questions about gains and losses to human and non-human realms. The work is structured in three main strands: Research on intelligent machines: an examination of the ontological shift that occurs when machines start to demonstrate lifelike behaviours such as adaptation and curiosity. The research leads to production of artworks and performances that use the tools of robotics for inviting critical responses to our relation with intelligent machines, uncharacteristic to the field. Design of human-robot interaction situations: opening the scope of human-robot interaction to areas of investigation not commonly explored by scientific or commercial applications, I create situations where machines unbiased by a utilitarian or benign agenda operate in direct contact with humans. The work questions the limitations of current machines and the necessity of their deployment. Participation: I create events that invite participation from audiences. Compared to more conventional outreach formats in art or science, the format allows for a broader range of human-machine interactions as well as a practical dissemination of critical reflections about technics. The unconventional aspects include hands-on processing of technological artefacts, shared experience with collective fabrication and direct dialogue. The new perspective developed in my artworks and papers is founded on a broader ethos of the robotic as an art practice that can be a vector for techno-critique with a social impact agenda.
title: Nutzung des Internets durch Langzeitüberlebende nach Prostatakarzinomdiagnose und deren subjektive Gewichtung und Einschätzung erkrankungsrelevanter Informationen
Creators: name: Linden, Arne Janosch
name: Dinkel, Andreas
name: Schiele, Stefan
name: Meissner, Valentin Henri
name: Gschwend, Jürgen Erich
name: Herkommer, Kathleen
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung/Ziel: Das Internet bietet eine stetig wachsende Quelle an Informationen. Dies erschwert dem Nutzer, die richtigen Informationen zu finden und diese auch korrekt einzuordnen. Ob Prostatakarzinom (PCa)-Patienten, welche häufig eine lange Überlebenszeit aufweisen, das Internet[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Heat capacity of liquids: A hydrodynamic approach
Creators: name: Bryk, T.
name: Scopigno, T.
name: Ruocco, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study autocorrelation functions of energy, heat and entropy densities obtained by molecular dynamics simulations of supercritical Ar and compare them with the predictions of the hydrodynamic theory. It is shown that the predicted by the hydrodynamic theory single-exponential shape of the entropy density autocorrelation functions is perfectly reproduced for small wave numbers by the molecular dynamics simulations and permits the calculation of the wavenumber-dependent specific heat at constant pressure. The estimated wavenumber-dependent specific heats at constant volume and pressure, $C_{v}(k)$ and $C_{p}(k)$, are shown to be in the long-wavelength limit in good agreement with the macroscopic experimental values of $C_{v}$ and $C_{p}$ for the studied thermodynamic points of supercritical Ar.
description: 8 pages, 5 figures
Upper and lower densities have the strong Darboux property
Creators: name: Leonetti, Paolo
name: Tringali, Salvatore
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Functional Analysis (math.FA)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: Primary 11B05, 28A10, Secondary 39B52, 60B99

description: Let $\mathcal{P}({\bf N})$ be the power set of $\bf N$. An upper density (on $\bf N$) is a non\-decreasing and subadditive function $μ^\ast: \mathcal{P}({\bf N})\to\bf R$ such that $μ^\ast({\bf N}) = 1$ and $μ^\ast(k \cdot X + h) = \frac{1}{k} μ^\ast(X)$ for all $X \subseteq \bf N$ and $h,k \in {\bf N}^+$, where $k \cdot X + h := \{kx + h: x \in X\}$. The upper asymptotic, upper Banach, upper logarithmic, upper Buck, upper Pólya, and upper analytic densities are examples of upper densities. We show that every upper density $μ^\ast$ has the strong Darboux property, and so does the associated lower density, where a function $f: \mathcal P({\bf N}) \to \bf R$ is said to have the strong Darboux property if, whenever $X \subseteq Y \subseteq \bf N$ and $a \in [f(X),f(Y)]$, there is a set $A$ such that $X\subseteq A\subseteq Y$ and $f(A)=a$. In fact, we prove the above under the assumption that the monotonicity of $μ^\ast$ is relaxed to the weaker condition that $μ^\ast(X) \le 1$ for every $X \subseteq \bf N$.
description: 10 pages, no figures. Fixed minor details and streamlined the exposition. To appear in Journal of Number Theory
title: Prädiktoren für die Risikowahrnehmung und die Besorgnis 45-jähriger Männer an Prostatakrebs zu erkranken
Creators: name: Wolfram, Arno
name: Dinkel, Andreas
name: Marten-Mittag, Birgit
name: Schulwitz, Helga
name: Albers, Peter
name: Arsov, Christian
name: Hohenfellner, Markus
name: Hadashik, Boris
name: Kuczyk, Markus
name: Imkamp, Florian
name: Gschwend, Jürgen Erich
name: Herkommer, Kathleen
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung/Ziel: Risikowahrnehmung und Krebssorgen sind bedeutende psychologische Variablen, die zu einer stärkeren Inanspruchnahme von Früherkennungsmaßnahmen führen. Ziel dieser Studie ist die Untersuchung möglicher Prädiktoren für die Risikowahrnehmung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Remarks on the static dipole-dipole potential at large distances
Creators: name: Giordano, Matteo
name: Meggiolaro, Enrico
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We determine the large-distance behaviour of the static dipole-dipole potential for a wide class of gauge theories on nonperturbative grounds, exploiting only general properties of the theory. In the case of QCD, we recover the known results in the regime of small dipole sizes, and discuss recent nonperturbative calculations. Moreover, we discuss the case of pure-gauge theories, and compare our prediction with the available lattice results.
description: Revised version; improved discussion of the choice of the Euclidean time direction, of the time-ordering of the Wilson loop, and of the comparison of our results with existing nonperturbative calculations; two references added. To appear in PRD. 30 pages, 2 figures
title: Regionale Variationen und Trends von TURP, offener Prostatektomie und radikaler Prostatektomie in Österreich: 2002–2016
Creators: name: Eredics, Klaus
name: Fülöp, Gerhard
name: Piso, Brigitte
name: Madersbacher, Stephan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Regionale Unterschiede in der Rate an Krankenhausaufnahmen und der Rate an Prostatektomien haben einen direkten Einfluss auf die Behandlungsqualität, Kosten und Ausbildung. Ziel dieser Arbeit war die Analyse der Rate an transurethraler Prostataresektion (TURP), offener suprapubischer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Comparative RNA-Seq Analysis Uncovers a Complex Regulatory Network for Soybean Cyst Nematode Resistance in Wild Soybean (Glycine soja)
Creators: name: Luo, Yan
name: Zhang, Hengyou
name: Kjemtrup-Lovelace, Susanne
name: Li, Changbao
name: Chen, Lars P.
name: Song, Bao-Hua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Soybean cyst nematode (SCN) is the most damaging pest of soybean worldwide. The molecular mechanism of SCN resistance remains largely unknown. We conducted a global RNA-seq comparison between a resistant genotype (S54) and a susceptible genotype (S67) of Glycine soja, the wild progenitor of soybean, to understand its regulatory network in SCN defense. The number of differentially expressed genes (DEGs) in S54 (2,290) was much larger than that in S67 (555). A number of defense-related genes/pathways were significantly induced only in S54, while photosynthesis and several metabolic pathways were affected in both genotypes with SCN infection. These defense-associated DEGs were involved in pathogen recognition, calcium/calmodulin-mediated defense signaling, jasmonic acid (JA)/ethylene (ET) and sialic acid (SA)-involved signaling, the MAPK signaling cascade, and WRKY-involved transcriptional regulation. Our results revealed a comprehensive regulatory network involved in SCN resistance and provided insights into the complex molecular mechanisms of SCN resistance in wild soybean.
Lorentz symmetry breaking effects on relativistic EPR correlations
Creators: name: Belich, H.
name: Furtado, C.
name: Bakke, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Lorentz symmetry breaking effects on relativistic EPR (Einstein-Podolsky-Rosen) correlations are discussed. From the modified Maxwell theory coupled to gravity, we establish a possible scenario of the Lorentz symmetry violation and write an effective metric for the Minkowski spacetime. Then, we obtain the Wigner rotation angle via the Fermi-Walker transport of spinors and consider the WKB ((Wentzel-Kramers-Brillouin) approximation in order to study the influence of Lorentz symmetry breaking effects on the relativistic EPR correlations.
description: Accepted for publication in The European Physical Journal C. arXiv admin note: substantial text overlap with arXiv:1504.07432, arXiv:1504.07262, arXiv:1412.5080, arXiv:1506.00562