cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Canadian clinical practice guidelines for acute and chronic rhinosinusitis
Creators: name: Desrosiers, Martin
name: Evans, Gerald A.
name: Keith, Paul K.
name: Wright, Erin D.
name: Kaplan, Alan
name: Bouchard, Jacques
name: Ciavarella, Anthony
name: Doyle, Patrick W.
name: Javer, Amin R.
name: Leith, Eric S.
name: Mukherji, Atreyi
name: Schellenberg, Robert
name: Small, Peter
name: Witterick, Ian J.
Publisher: name: BioMed Central
Year: 2016

description: This document provides healthcare practitioners with information regarding the management of acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) to enable them to better meet the needs of this patient population. These guidelines describe controversies in the management of acute bacterial rhinosinusitis (ABRS) and include recommendations that take into account changes in the bacteriologic landscape. Recent guidelines in ABRS have been released by American and European groups as recently as 2007, but these are either limited in their coverage of the subject of CRS, do not follow an evidence-based strategy, or omit relevant stakeholders in guidelines development, and do not address the particulars of the Canadian healthcare environment. Advances in understanding the pathophysiology of CRS, along with the development of appropriate therapeutic strategies, have improved outcomes for patients with CRS. CRS now affects large numbers of patients globally and primary care practitioners are confronted by this disease on a daily basis. Although initially considered a chronic bacterial infection, CRS is now recognized as having multiple distinct components (eg, infection, inflammation), which have led to changes in therapeutic approaches (eg, increased use of corticosteroids). The role of bacteria in the persistence of chronic infections, and the roles of surgical and medical management are evolving. Although evidence is limited, guidance for managing patients with CRS would help practitioners less experienced in this area offer rational care. It is no longer reasonable to manage CRS as a prolonged version of ARS, but rather, specific therapeutic strategies adapted to pathogenesis must be developed and diffused. Guidelines must take into account all available evidence and incorporate these in an unbiased fashion into management recommendations based on the quality of evidence, therapeutic benefit, and risks incurred. This document is focused on readability rather than completeness, yet covers relevant information, offers summaries of areas where considerable evidence exists, and provides recommendations with an assessment of strength of the evidence base and degree of endorsement by the multidisciplinary expert group preparing the document. These guidelines have been copublished in both Allergy, Asthma & Clinical Immunology and the Journal of Otolaryngology-Head and Neck Surgery.
Curating cell types using Wikidata Bib - UK Local Biocuration Conference
Creators: name: Lubiana, Tiago
Publisher: name: Zenodo
Year: 2022
Subjects: Wikidata
Cell types
Biocuration

description: Presentation for the 1st UK Local Biocuration Conference. Note: Some content on the presentation might contain rights elsewhere and are used under fair use. CC-BY is applied whenever I hold the rights.

 Pictures of the library (first slide): https://commons.wikimedia.org/wiki/File:%E3%83%AA%E3%82%AA%E3%81%AE%E5%B9%BB%E6%83%B3%E5%9B%B3%E6%9B%B8%E9%A4%A8_Real_Gabinete_Portugues_de_Leitura_(8735773218).jpg
Naar een stimulerende omgeving voor agroforestry in Vlaanderen: Roadmap 2.0
Creators: name: Tavernier, Helena
name: Koopmans, Marlinde
name: Reubens, Bert
Publisher: name: Zenodo
Year: 2024
Subjects: agroforestry
policy
revenue model
education
stimuli
science and technology
social environment
agroecology

description: To create a stimulating environment for agroforestry in Flanders, the Consortium Agroforestry Flanders published a roadmap with priority actions by 2035. This included input from the master classes, excursions, workshops and analyses organised or conducted by the Consortium in recent years.

There is work to be done on five ‘paths’ according to the roadmap: in research and development, education, policy, economy and social environment. Concrete bottlenecks cited include access to land, fair prices, remuneration of ecosystem services but also lack of experimentation space by pioneering farmers and the need for independent advice and guidance. But there are also many opportunities. For each of these five paths, the Consortium Agroforestry Flanders puts forward a vision of the future.
An Interview with Dr. Bambi Schieffelin
Creators: name: Tadic, Nadja
name: Yu, Di
name: Frantz, Kelly Katherine
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2020

description: On June 12, 2018, Dr. Hansun Zhang Waring’s Language Socialization class at Teachers College, Columbia University had the great pleasure and honor of being joined by Dr. Bambi Schieffelin, Collegiate Professor at New York University. A co-founder (with Elinor Ochs) of the field of language socialization, Dr. Schieffelin has done extensive research on linguistic anthropology, language ideology, literacy, missionization, and much, much more. She is the author of the ethnography The Give and Take of Everyday Life: Language Socialization of Kaluli Children, co-author of the classic chapter “Language Acquisition and Socialization: Three Developmental Stories and Their Implications,” and co-author of the Handbook of Language Socialization—a foundational reference work for all language socialization scholars. In this interview, she shares her path to Language Socialization (LS), experiences from her groundbreaking LS work in Papua New Guinea, affordances, obstacles, and recent developments in LS research, and key takeaways for LS researchers.
description: Studies in Applied Linguistics and TESOL, Vol 20 No 1 (2020)
An Interview with APPLE Lecture Speaker Dr. Richard Donato
Creators: name: Frantz, Kelly Katherine
name: Fernandez, Kaylee Nicole
name: Stabler-Havener, Michelle
name: Tadic, Nadja
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2020

description: On March 6, 2020, the Studies in Applied Linguistics and TESOL (SALT) journal had the great pleasure of interviewing Dr. Richard Donato, the invited speaker for the 2020 APPLE Lectures Series hosted by the Applied Linguistics and TESOL Program at Teachers College, Columbia University. Dr. Donato was kind enough to take the time, during a very busy day, to speak about his work on teacher training, history-in-person, and culture in the language classroom.
description: Studies in Applied Linguistics and TESOL, Vol 20 No 1 (2020)
Language and Subjectivity
Creators: name: Blain, Hayden Robert
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2020

description: The study of language and identity has taken many forms, but Language and Subjectivity presents a rigorous, empirical, and theoretically-informed perspective on how we might investigate the relationship between language and identity. Tim McNamara, a renowned applied linguist in the field of language testing, takes a deep understanding of poststructuralist thought—particularly the theories of Michel Foucault, Jacques Derrida, and Judith Butler—and applies this to established areas of applied linguistics. McNamara carefully interweaves discussions of poststructuralist thinking into discussions of language—including everyday conversation, language learning, and language testing.
description: Studies in Applied Linguistics and TESOL, Vol 20 No 1 (2020)
Readers' Credits for Volume 20, Issue 1
Creators: name: Tadic, Nadja
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2020

description: Studies in Applied Linguistics & TESOL (SALT) would like to thank the following individuals for reviewing the contributions for Volume 20, Issue 1 (2020)
description: Studies in Applied Linguistics and TESOL, Vol 20 No 1 (2020)
Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
Creators: name: Thabane, Lehana
name: Wells, George
name: Cook, Richard
name: Platt, Robert
name: Pogue, Janice
name: Pullenayegum, Eleanor
name: Matthews, David
name: McCready, Tara
name: Devereaux, Philip J
name: Cairns, John A
name: Yusuf, Salim
Publisher: name: BioMed Central
Year: 2016

description: The Biostatistics and Methodological Innovation Working (BMIW) Group is one of several working groups within the CANadian Network and Centre for Trials INternationally (CANNeCTIN). This programme received funding from the Canadian Institutes of Health Research and the Canada Foundation for Innovation beginning in 2008, to enhance the infrastructure and build capacity for large Canadian-led clinical trials in cardiovascular diseases (CVD) and diabetes mellitus (DM). The overall aims of the BMIW Group's programme within CANNeCTIN, are to advance biostatistical and methodological research, and to build biostatistical capacity in CVD and DM. Our program of research and training includes: monthly videoconferences on topical biostatistical and methodological issues in CVD/DM clinical studies; providing presentations on methods issues at the annual CANNeCTIN meetings; collaborating with clinician investigators on their studies; training young statisticians in biostatistics and methods in CVD/DM trials and organizing annual symposiums on topical methodological issues. We are focused on the development of new biostatistical methods and the recruitment and training of highly qualified personnel - who will become leaders in the design and analysis of CVD/DM trials. The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM.
Evaluating Test Consequences Based on ESL Students’ Perceptions: An Appraisal Analysis
Creators: name: Lee, Elizabeth
Publisher: name: Studies in Applied Linguistics and TESOL
Year: 2020

description: Ensuring that test-score use brings about socially positive consequences for test-takers is an important aspect of test validation. While many studies use an inductive approach to evaluate test consequences, few studies have implemented Appraisal analysis. To that end, this case study investigated the test consequences of an English reading placement test administered at a large American university. In this study, English as a second language (ESL) students (n=8) who took the placement test and an ESL reading course were interviewed; an Appraisal analysis was conducted to identify the students’ positive and/or negative perceptions toward the placement test and reading course. Using an argument-based approach to validity framework, the findings were treated as evidence to evaluate the test consequences of the placement test. The results showed that, while taking the ESL course helped students gain some valuable academic reading skills, students felt that test anxiety, fatigue, and verbally demanding questions hindered their test performances. Understanding what students experienced while taking the test can help test-developers devise solutions that will improve the test-taking situation for future test-takers. This study also illustrates how an Appraisal analysis of test-takers’ discourses can provide a systematic and fine-grained approach to evaluating positive and/or negative test consequences.
description: Studies in Applied Linguistics and TESOL, Vol 20 No 1 (2020)
The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study
Creators: name: Bellapart, Judith
name: Chan, Gregory S.
name: Tzeng, Yu-Chieh
name: Ainslie, Philip N., 1974-
name: Barnett, Adrian G.
name: Dunster, Kimble R.
name: Boots, Rob
name: Fraser, John F.
Publisher: name: BioMed Central
Year: 2015

description: Background: The insertion of Ventricular Assist Devices is a common strategy for cardiovascular support in patients with refractory cardiogenic shock. This study sought to determine the impact of ventricular assist devices on the dynamic relationship between arterial blood pressure and cerebral blood flow velocity. Methods A sample of 5 patients supported with a pulsatile ventricular assist device was compared with 5 control patients. Controls were matched for age, co-morbidities, current diagnosis and cardiac output state, to cases. Beat-to-beat recordings of mean arterial pressure and cerebral blood flow velocity, using transcranial Doppler were obtained. Transfer function analysis was performed on the lowpass filtered pressure and flow signals, to assess gain, phase and coherence of the relationship between mean arterial blood pressure and cerebral blood flow velocity. These parameters were derived from the very low frequency (0.02-0.07 Hz), low frequency (0.07-0.2 Hz) and high frequency (0.2-0.35 Hz). Results No significant difference was found in gain and phase values between the two groups, but the low frequency coherence was significantly higher in cases compared with controls (mean ± SD: 0.65 ± 0.16 vs 0.38 ± 0.19, P = 0.04). The two cases with highest coherence (~0.8) also had much higher spectral power in mean arterial blood pressure. Conclusions Pulsatile ventricular assist devices affect the coherence but not the gain or phase of the cerebral pressure-flow relationship in the low frequency range; thus whether there was any significant disruption of cerebral autoregulation mechanism was not exactly clear. The augmentation of input pressure fluctuations might contribute in part to the higher coherence observed.
D7.3 IP4MaaS leaflet, version 1
Creators: name: Rizzi, Giuseppe
Publisher: name: Zenodo
Year: 2021

description: This deliverable describes and shows the first version of the Project Leaflet developed by the IP4MaaS project. In this document, we describe the objectives of the leaflet, as well as the structure and design. This first leaflet, delivered in M10, is the first out of two. A final IP4MaaS leaflet will be delivered in M20 and will focus on project pilots and results.
LEVEL OF PROBLEM-SOLVING SKILLS AND MATHEMATICS ACHIEVEMENT OF SENIOR HIGH SCHOOL LEARNERS BY THE USE OF k-GAS METHOD
Creators: name: JASON RAY B. JUSOY
name: FLORDELINE A. CADELINA
name: EDEN ROSE N. MACALONG
name: JAN CLEO D. CANOY
name: WENCESLAO A. CORONADO
Publisher: name: Zenodo
Year: 2024
Subjects: Digital Mnemonic System, k-GAS Method, Mathematics Achievement, Problem-Solving Skills.

description: Abstract

To succeed as a 21st century learner, essential skills like problem-solving, metacognition, and communication are vital. This study introduces the k-GAS Method, a digital mnemonic system for 3-Reads Protocol, which helps students identify keywords, given and asked, and solutions in mathematics word problems. The research examines senior high school learners’ problem-solving skills, mathematics achievement, and the perceived impact of the k-GAS Method. Using a pretest and post-test design, findings from 43 students reveal that the method improved their math performance from “Average” to “Moving towards Mastery”, highlighting its effectiveness in enhancing both problem-solving and reading comprehension.
Promoting Community Forestry Enterprises in National REDD+ Strategies : A Business Approach
Creators: name: Tomaselli, Maria Fernanda
name: Hajjar, Reem
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Community forestry and related small and medium forest enterprises (SMFEs) can contribute towards the achievement of REDD+ goals, since they can promote sustainable use and conservation of forests and, therefore, a reduction in forest-related carbon emissions. Additionally, they can improve the quality of life of forest-dependant people by generating alternative sources of income and employment. However, SMFEs often face a number of challenges, including non-conducive policy environments, inadequate business skills, and moreover, limited access to financial services. In this paper, we propose to direct a portion of REDD+ readiness efforts towards promoting the generation of an enabling environment for SMFEs that includes: the construction of an adequate Business Environment (BE), the provision of Business Development Services (BDS) and better access to Financial Services (FS). With the application of this framework, SMFEs will be more likely to proliferate and succeed, leading to enhanced community resilience and empowerment, in addition to increasing the likelihood of forest carbon stock permanence and the long term achievement of REDD+ goals. Opportunities and challenges of applying this approach in Latin America are discussed.
D7.1 Project Visual Identity & Templates
Creators: name: van Hek, Charlotte
Publisher: name: Zenodo
Year: 2021

description: This document describes the objectives, structure, and look and feel of the IP4MaaS visual identity and templates. The visual identity is an essential means for the IP4MaaS project to reach its objectives concerning communication, as well as strengthening the project’s identity and positioning IP4MaaS as a strong brand.
Bilan 2023 & perspectives 2024 du programme de recherche BVH
Creators: name: Lastraioli, Chiara
Publisher: name: Bibliothèques Virtuelles Humanistes. Zenodo
Year: 2024
Subjects: recherche
shs
humanités numériques
patrimoine écrit
bibliothèques virtuelles
édition numérique
XVIe
valorisation
Livres anciens
histoire du livre
littérature
publications
renaissance

description: Présentation du bilan 2023 et des perspectives par Chiara Lastraioli - Responsable scientifique, à l'occasion de l’assemblée générale 2023 du programme de recherche « Bibliothèques Virtuelles Humanistes » (CESR, Tours) et de l'anniversaire des 20 ans du programme BVH. Vendredi 24 novembre 2023, au Centre d’Études Supérieures de la Renaissance de Tours.
title: Germanium and Gallium: U.S. Trade and Chinese Export Controls
Creators: name: Blackwood, Matthew
name: DeFilippo, Catherine
Publisher: name: United States International Trade Commission
publisherIdentifier: https://ror.org/05hsggr76
publisherIdentifierScheme: ROR
Year: 2024

description: The global supply chain for germanium and gallium is expected to encounter significant changes with the
Chinese government’s announcement of new export controls on these critical minerals, effective August 1,
2023. Germanium and gallium hold immense importance in various industries such as semiconductors,
solar panels, and electric vehicles. The United States is heavily reliant on imports for both of these critical
minerals, especially from China given its dominant role as a major producer and supplier of both products.
This executive briefing explores the potential implications of China’s export controls on the United States
Public crack cocaine smoking and willingness to use a supervised inhalation facility: implications for street disorder
Creators: name: DeBeck, Kora
name: Buxton, Jane A.
name: Kerr, Thomas
name: Qi, Jiezhi
name: Montaner, Julio
name: Wood, Evan
Publisher: name: BioMed Central
Year: 2015

description: Background: The health risks of crack cocaine smoking in public settings have not been well described. We sought to identify factors associated with public crack smoking, and assess the potential for a supervised inhalation facility to reduce engagement in this behavior, in a setting planning to evaluate a medically supervised crack cocaine smoking facility. Methods Data for this study were derived from a Canadian prospective cohort of injection drug users. Using multivariate logistic regression we identified factors associated with smoking crack cocaine in public areas. Among public crack smokers we then identified factors associated with willingness to use a supervised inhalation facility. Results Among our sample of 623 people who reported crack smoking, 61% reported recently using in public locations. In multivariate analysis, factors independently associated with public crack smoking included: daily crack cocaine smoking; daily heroin injection; having encounters with police; and engaging in drug dealing. In sub analysis, 71% of public crack smokers reported willingness to use a supervised inhalation facility. Factors independently associated with willingness include: female gender, engaging in risky pipe sharing; and having encounters with police. Conclusion We found a high prevalence of public crack smoking locally, and this behavior was independently associated with encounters with police. However, a majority of public crack smokers reported being willing to use a supervised inhalation facility, and individuals who had recent encounters with police were more likely to report willingness. These findings suggest that supervised inhalation facilities offer potential to reduce street-disorder and reduce encounters with police.
A simple model for behaviour change in epidemics
Creators: name: Brauer, Fred
Publisher: name: BioMed Central
Year: 2015

description: Background. People change their behaviour during an epidemic. Infectious members of a population may reduce the number of contacts they make with other people because of the physical effects of their illness and possibly because of public health announcements asking them to do so in order to decrease the number of new infections, while susceptible members of the population may reduce the number of contacts they make in order to try to avoid becoming infected. Methods We consider a simple epidemic model in which susceptible and infectious members respond to a disease outbreak by reducing contacts by different fractions and analyze the effect of such contact reductions on the size of the epidemic. We assume constant fractional reductions, without attempting to consider the way in which susceptible members might respond to information about the epidemic. Results We are able to derive upper and lower bounds for the final size of an epidemic, both for simple and staged progression models. Conclusions The responses of uninfected and infected individuals in a disease outbreak are different, and this difference affects estimates of epidemic size.
The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes
Creators: name: Thomas, Maria
name: Bayha, Christine
name: Klein, Kathrin
name: Müller, Simon
name: Weiss, Thomas S.
name: Schwab, Matthias
name: Zanger, Ulrich M.
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: Alternative splicing Fibrates Hepatocarcinogenesis PPARA Primary human hepatocytes Inflammation Proliferation WNT/β-catenin
subject: 610 Medizin

description: Abstract
Background

The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative function despite being unable to bind consensus PPARα DNA response elements.
Methods

The distribution and variability factor of each PPARα variant were assessed in the well-characterized cohort of human liver samples (N = 150) on the mRNA and protein levels. Specific siRNA-mediated downregulation of each transcript as well as specific overexpression with subsequent qRT-PCR analysis of downstream genes was used for investigation of specific functional roles of PPARα-wt and PPARα-tr forms in primary human hepatocytes.
Results

Bioinformatic analyses of genome-wide liver expression profiling data suggested a possible role of PPARα-tr in downregulating proliferative and pro-inflammatory genes. Specific gene silencing of both forms in primary human hepatocytes showed that induction of metabolic PPARα-target genes by agonist WY14,643 was prevented by PPARα-wt knock-down but neither prevented nor augmented by PPARα-tr knock-down. WY14,643 treatment did not induce proliferative genes including MYC, CDK1, and PCNA, and knock-down of PPARα-wt had no effect, while PPARα-tr knock-down caused up to 3-fold induction of these genes. Similarly, induction of pro-inflammatory genes IL1B, PTGS2, and CCL2 by IL-6 was augmented by knock-down of PPARα-tr but not of PPARα-wt. In contrast to human proliferative genes, orthologous mouse genes were readily inducible by WY14,643 in PPARα-tr non-expressing AML12 mouse hepatocytes. Induction was augmented by overexpression of PPARα-wt and attenuated by overexpression of PPARα-tr. Pro-inflammatory genes including IL-1β, CCL2 and TNFα were induced by WY14,643 in mouse and human cells and both PPARα forms attenuated induction. As potential mechanism of PPARα-tr inhibitory action we suggest crosstalk with WNT/β-catenin pathway. Finally, treatment with WY14,643 in the presence of PPARα-tr resulted in the significant reduction of cell viability of AML12 and human ovarian cancer cell line, SKOV3.
Conclusions

Our data suggest that the truncated PPARα splice variant functions as an endogenous inhibitor of proliferative and pro-inflammatory genes in human cells and that its absence in mouse may explain species-specific differences in fibrate-induced hepatocarcinogenesis.
Fare Open Access e farlo correttamente [corso di formazione, 11/03/2025]
Creators: name: Aliprandi, Simone
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Open Access Publishing
subject: Copyright
subject: Intellectual Property
subject: open data

description: Le slides per il corso di formazione intitolato "Fare Open Access e farlo correttamente", organizzato da CAEB per il personale di Università degli studi di Trieste e tenutosi da remoto martedì 11 marzo 2025.
D2.2 Demonstration requirements and scenarios C-REL
Creators: name: Carenini, Alessio
Publisher: name: Zenodo
Year: 2022

description: This document provides: • A detailed description of the methodology adopted by the IP4MaaS project for the definition of demonstration requirements and scenarios. The methodology, based on the principles of the participatory design, supports: (i) the identification of aim and objectives of each demonstration, highlighting the needs and expectations expressed by the stakeholders involved; (ii) the definition of maps representing clear pictures of current multimodal travel experiences in the demonstration site, highlighting problems and areas for potential improvement; (iii) the definition of another set of maps representing new travel experiences enabled by the integration of IP4 technologies and TSP services, and (iv) the identification of demonstration requirements and scenarios supporting the planning and execution of the IP4MaaS demonstrations.• The results of the application of the methodology to Barcelona, Athens, and Padua that are the demonstration sites involved in IP4MaaS C-REL demonstrations. • A preliminary analysis of the other three demonstration sites (i.e., Liberec, Osijek, and Warsaw) that will contribute to the definition of demonstration scenarios for the IP4MaaS F-REL demonstrations. • The list of Shift2Rail IP4 functionalities that are candidates to be tested by IP4MaaS for C-REL demonstrations for each involved demonstration site.
Pulse Asia Research Poll: March 2011 Ulat ng Bayan Survey
Creators: name: Pulse Asia Research
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Poverty and living standards (5); household expenditures (6); personal quality of life (2); national quality of life (2); urgent personal concerns (3); urgent national concerns (3); ratings of officials and government agencies (60); ratings of national administration on select issues (11); trust ratings of government officials (33); media credibility (3); public safety and crime (5); government agencies with least, most graft and corruption (2); corruption in the military (3); Mindanao (6); disaster preparedness and relief (6); martial law (1); hopelessness (1); moving to another country (1).
Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle
Creators: name: Yang, Hyun
name: Kim, Tae-Hee
name: Lee, Hae-Hyeog
name: Choi, Kyung-Chul
name: Hong, Yeon-Pyo
name: Leung, P. C. K.
name: Jeung, Eui-Bae
Publisher: name: BioMed Central
Year: 2015

description: Human endometrium resists embryo implantation except during the 'window of receptivity'. A change in endometrial gene expression is required for the development of receptivity. Uterine calbindin-D28k (CaBP-28k) is involved in the regulation of endometrial receptivity by intracellular Ca2+. Currently, this protein is known to be mainly expressed in brain, kidneys, and pancreas, but potential role(s) of CaBP-28k in the human uterus during the menstrual cycle remain to be clarified. Thus, in this study we demonstrated the expression of CaBP-28k in the human endometrium in distinct menstrual phases. During the human menstrual cycle, uterine expression levels of CaBP-28k mRNA and protein increased in the proliferative phase and fluctuated in these tissues, compared with that observed in other phases. We assessed the effects of two sex-steroid hormones, 17beta-estradiol (E2) and progesterone (P4), on the expression of CaBP-28k in Ishikawa cells. A significant increase in the expression of CaBP-28k mRNA was observed at the concentrations of E2 (10(-9 to -7) M). In addition, spatial expression of CaBP-28k protein was detected by immunohistochemistry. CaBP-28k was abundantly localized in the cytoplasm of the luminal and glandular epithelial cells during the proliferative phases (early-, mid-, late-) and early-secretory phase of menstrual cycle. Taken together, these results indicate that CaBP-28k, a uterine calcium binding protein, is abundantly expressed in the human endometrium, suggesting that uterine expression of CaBP-28k may be involved in reproductive function during the human menstrual cycle.
Attenuated and Protease-Profile Modified Sendai Virus Vectors as a New Tool for Virotherapy of Solid Tumors
Creators: name: Takimoto, Toru
name: Zimmermann, Martina
name: Armeanu-Ebinger, Sorin
name: Bossow, Sascha
name: Lampe, Johanna
name: Smirnow, Irina
name: Schenk, Andrea
name: Lange, Sebastian
name: Weiss, Thomas S.
name: Neubert, Wolfgang
name: Lauer, Ulrich M.
name: Bitzer, Michael
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: 610 Medizin

description: Abstract

Multiple types of oncolytic viruses are currently under investigation in clinical trials. To optimize therapeutic outcomes it is believed that the plethora of different tumor types will require a diversity of different virus types. Sendai virus (SeV), a murine parainfluenza virus, displays a broad host range, enters cells within minutes and already has been applied safely as a gene transfer vector in gene therapy patients. However, SeV spreading naturally is abrogated in human cells due to a lack of virus activating proteases. To enable oncolytic applications of SeV we here engineered a set of novel recombinant vectors by a two-step approach: (i) introduction of an ubiquitously recognized cleavage-motive into SeV fusion protein now enabling continuous spreading in human tissues, and (ii) profound attenuation of these rSeV by the knockout of viral immune modulating accessory proteins. When employing human hepatoma cell lines, newly generated SeV variants now reached high titers and induced a profound tumor cell lysis. In contrast, virus release from untransformed human fibroblasts or primary human hepatocytes was found to be reduced by about three log steps in a time course experiment which enables the cumulation of kinetic differences of the distinct phases of viral replication such as primary target cell infection, target cell replication, and progeny virus particle release. In a hepatoma xenograft animal model we found a tumor-specific spreading of our novel recombinant SeV vectors without evidence of biodistribution into non-malignant tissues. In conclusion, we successfully developed novel tumor-selective oncolytic rSeV vectors, constituting a new tool for virotherapy of solid tumors being ready for further preclinical and clinical development to address distinct tumor types.
Risk of cerebrovascular disease associated with the use of glucocorticoids in patients with incident rheumatoid arthritis : a population-based study
Creators: name: Aviña-Zubieta, J. Antonio
name: Abrahamowicz, Michal
name: Choi, Hyon
name: Rahman, Md Mushfiqur
name: Sylvestre, Marie-Pierre
name: Esdaile, John
name: Lacaille, Diane
Publisher: name: The University of British Columbia
Year: 2020

description: Objectives: To determine the effect of glucocorticoids (GC) on the risk of cerebrovascular accidents (CVA) in patients with rheumatoid arthritis (RA). Methods: A population-based cohort study was carried out using administrative health data on 7051 individuals with RA onset between 1997 and 2001 and no exposure to GC before RA onset. Follow-up was until 2006. GC exposure was defined in four ways: current use (yes/no), current dose (mg/day), cumulative dose (grams) and cumulative duration of use (years). All were used as time-dependent variables updated monthly. CVA were ascertained using hospitalisation and vital statistics data. Transient ischaemic attacks were not considered as CVA. Cox regression models adjusting for demographics, cardiovascular drug use, propensity scores and RA characteristics were used. Results: The mean age of the cohort was 56 years and 66% were women. Over 6 years’ mean follow-up (43 355 person-years), 178 incident CVA cases were identified. GC current use was not associated with a significant increase in the risk of CVA (HR=1.41, 95% CI 0.84 to 2.37). Similarly, the models that accounted for daily dose (HR=1.07, 95% CI 0.94 to 1.21 for each 5 mg increase in the daily dose), cumulative duration of use (HR=1.1, 95% CI 0.94 to 1.32 for each year accumulated in the past) and total cumulative dose (HR=1.04, 95% CI 0.99 to 1.08 per gram accumulated in the past) were also not significantly associated with CVA. Conclusions: This large population-based study indicates that GC use is not associated with an increased risk of CVA in cases with RA.
title: Diversity of Trametes (Polyporales, Basidiomycota) in tropical Benin and description of new species Trametes parvispora
Creators: name: Olou, Boris Armel
name: Krah, Franz-Sebastian
name: Piepenbring, Meike
name: Yorou, Nourou Soulemane
name: Langer, Ewald
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: Africa
subject: morphology
subject: new taxa
subject: phylogeny
subject: Polyporales
subject: taxonomy
subject: tropics
subject: white rot
subject: 570
subject: 580
subject: Stielporling
subject: Pflanzenmorphologie
subject: Taxon
subject: Phylogenie
subject: Polyporales
subject: Taxonomie
subject: Weißfäulepilze
subject: Tropischer Regenwald
subject: Afrika

description: Gefördert durch den Publikationsfonds der Universität Kassel
title: Easy Being Green? EU Sustainability Policies and the Textile & Apparel Industry
Creators: name: Howlett, Elizabeth
Publisher: name: United States International Trade Commission
publisherIdentifier: https://ror.org/05hsggr76
publisherIdentifierScheme: ROR
Year: 2024

description: The European Union (EU) has proposed a variety of environmental policies that will likely impact the textile and
apparel industry. These initiatives include legislation to promote circular economic activities and ensure corporate
responsibility for sustainability compliance throughout the supply chain. Because the EU is a major global importer
of textiles and apparel, its policies could affect suppliers in countries beyond the bloc. This EBoT provides an
overview of select EU sustainability policies relevant to the global textile and apparel industry.
title: Sentences around comparative notions and adjectives
Creators: name: Fily, Maxime
Publisher: name: Pangloss
Year: 2024
Subjects: subject: Linguistique
subject: Lataddi Narua

description: The recording was done in order to (i) elicit adjectif while (ii) maintaining a naturalistic sense by proposing stimuli where the speaker would be asked to tell which is larger, who is taller, which is blue, which is green, etc.
MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model
Creators: name: Le Béchec, Antony
name: Portales-Casamar, Elodie
name: Vetter, Guillaume
name: Moes, Michèle
name: Zindy, Pierre-Joachim
name: Saumet, Anne
name: Arenillas, David
name: Theillet, Charles
name: Wasserman, Wyeth W.
name: Lecellier, Charles-Henri
name: Friederich, Evelyne
Publisher: name: BioMed Central
Year: 2016

description: Background: To understand biological processes and diseases, it is crucial to unravel the concerted interplay of transcription factors (TFs), microRNAs (miRNAs) and their targets within regulatory networks and fundamental sub-networks. An integrative computational resource generating a comprehensive view of these regulatory molecular interactions at a genome-wide scale would be of great interest to biologists, but is not available to date. Results: To identify and analyze molecular interaction networks, we developed MIR@NT@N, an integrative approach based on a meta-regulation network model and a large-scale database. MIR@NT@N uses a graph-based approach to predict novel molecular actors across multiple regulatory processes (i.e. TFs acting on protein-coding or miRNA genes, or miRNAs acting on messenger RNAs). Exploiting these predictions, the user can generate networks and further analyze them to identify sub-networks, including motifs such as feedback and feedforward loops (FBL and FFL). In addition, networks can be built from lists of molecular actors with an a priori role in a given biological process to predict novel and unanticipated interactions. Analyses can be contextualized and filtered by integrating additional information such as microarray expression data. All results, including generated graphs, can be visualized, saved and exported into various formats. MIR@NT@N performances have been evaluated using published data and then applied to the regulatory program underlying epithelium to mesenchyme transition (EMT), an evolutionary-conserved process which is implicated in embryonic development and disease. Conclusions: MIR@NT@N is an effective computational approach to identify novel molecular regulations and to predict gene regulatory networks and sub-networks including conserved motifs within a given biological context. Taking advantage of the M@IA environment, MIR@NT@N is a user-friendly web resource freely available at http://mironton.uni.lu which will be updated on a regular basis.
Statin discontinuation and risk of acute myocardial infarction in patients with rheumatoid arthritis : a population-based cohort study
Creators: name: De Vera, Mary
name: Choi, Hyon
name: Abrahamowicz, Michal
name: Kopeć, Jacek A.
name: Goycochea-Robles, Maria Victoria
name: Lacaille, Diane
Publisher: name: The University of British Columbia
Year: 2020

description: Objectives Screening for cardiovascular risk factors and treating hyperlipidaemia with statins are recommended to reduce the increased cardiovascular risk in individuals with rheumatoid arthritis (RA). However, poor compliance with statins may limit their therapeutic benefit. Our objective was to evaluate the impact of statin discontinuation on risk of acute myocardial infarction (AMI) among RA patients. Methods The authors conducted a population-based cohort study of RA patients with incident statin use followed from May 1996 to March 2006 using administrative health data. Primary exposure was statin discontinuation for ≥3 months at any time during therapy course. The authors used Cox’s proportional hazards models and modelled statin discontinuation as a time-dependent variable, while adjusting for age, sex, comorbidities, use of other medications influencing cardiac risk, and proxy indicators of RA severity. Results During 15 669 person-years of follow-up in 4102 incident-statin users with RA, the authors identified 264 AMI events. Statin discontinuation was associated with 67% increased risk of AMI (adjusted HR 1.67; 95% CI 1.24 to 2.25). There was a 2% increase in risk of AMI with each 1-month increase in the duration of discontinuation (adjusted HR 1.02; 95% CI 1.01 to 1.03). These associations were not modified by timing of first statin prescription, prior AMI status, sex and age (p values for interactions >0.17). Conclusions These population-based data indicate that RA patients who discontinue statins have increased risk of AMI. Findings emphasise the need to raise awareness, among health professionals and people with RA, of the importance of compliance with statin therapy in RA.
Open Access and Open Science in the Global South
Creators: name: Anup Kumar Das
Publisher: name: Zenodo
Year: 2020
Subjects: Open Science
Open Data
Open Access
India
South Asia
Global South

description: The presentation titled "Open Access and Open Science in the Global South" was delivered in an Online Workshop on "Research Ethics and Quantitative Techniques for Research and Publications" on 30 April 2020, organized by G.G. Dutta S.D. College, Chandigarh, India. It covers the open access and open science initiatives in India and the country's position in the Global South.
description: Organized in partnership with the Open Access of India (OAI).
Erasmus for All Policy Recommendations
Creators: name: Schrooyen, Arno
name: Lopes, Duarte
name: Tsaklidou, Vasiliki
Publisher: name: Erasmus For All Partnership
Year: 2024
Subjects: Erasmus+
Inclusion
Student Grants
Student Mobility
Policy recommendations

description: This document presents the comprehensive journey and outcomes of the Erasmus for All Partnership, launched in November 2021 to improve accessibility in the Erasmus+ Programme (2021-2027) by addressing funding barriers in mobility grants. This publication shares actionable policy recommendations for stakeholders, advocating for an equitable and sustainable future for Erasmus+.

The “Erasmus for All” project aims to tackle the low levels of Higher Education (HE) student participation in Erasmus mobility exchange by proposing a more economically viable scholarship scheme that will allow any HE students to spend part of their studies abroad in any of the 33 programme countries.
THE INFLUENCE OF SERVICE QUALITY, COMPLEXITY OF THE TAX SYSTEM, ACCOUNTING MENTALITY, TAX AUDIT, COMPLIANCE COSTS AND RISK PREFERENCES ON TAXPAYERS' AWARENESS AND COMPLIANCE IN ONLINE TAX SYSTEM MODERATION FOR MSMEs IN THE CITY OF SURABAYA
Creators: name: MOHAMMED TAUFIQ HIDAYAT
name: TRI RATNAWATI
name: SLAMET RIYADI
Publisher: name: Zenodo
Year: 2024
Subjects: Complexity of Tax System, Accounting Mentality, Compliance Costs, Taxpayer Awareness, Online Tax System.

description: Abstract

The purpose of this study is to determine the influence of service quality, complexity of the tax system, accounting mentality, tax audit, compliance costs and risk preferences on mandatory awareness and tax compliance in the moderation of the online tax system in MSMEs in the city of Surabaya. This study is a quantitative research with data collection techniques through observation, questionnaires, and interviews, as well as data analysis techniques using a questionnaire validity and reliability test of 229 respondents with the Structural Equation Modeling (SEM AMOS) program on taxpayers of MSME Agencies in the city of Surabaya. The results of this study show that the complexity of the tax system has no effect on taxpayer compliance; accounting mentality has no effect on taxpayer compliance; tax audit has no effect on tax awareness; and risk preference has no effect on tax awareness. So there are 10 other hypotheses that have an influence. The results of the total effect analysis showed a sequence of variables that had a significant effect on taxpayer compliance as indicated by the probability value (p-value) ranging from tax awareness, tax service quality, risk preferences, accounting mentality, complexity of the tax system, compliance costs, and tax audits.
"The Graviton as a Fundamental Structure of the Universe: Establishing a Theoretical Framework for Its Role as a Universal Element"
Creators: name: Touloumidis, Stylianos
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 510105
subject: General relativity and gravitational waves
classificationCode: 490204
subject: Mathematical aspects of general relativity

description: Theoretical Proposition In recent years, there has been a growing interest in understanding the fundamental structure of the universe. Among the most intriguing possibilities is the idea that the graviton, often considered a hypothetical quantum particle mediating gravitational interaction, might be more than a force carrier. We propose that the graviton is, in fact, a universal structure that consistently affects all forms of matter and energy across all scales and dimensions. Unlike particles bound to specific interactions, the graviton would possess a structural quality, underpinning the very framework of space-time and gravitational interactions. The objective of this paper is to present a structured analysis of this hypothesis through precise calculations across diverse physical contexts. By systematically testing the graviton’s effect in scenarios ranging from quantum scales to cosmological distances, from high temperatures to intense gravitational fields, we aim to establish the universality and invariance of the graviton’s influence. This theoretical proposition, if validated, could redefine our understanding of gravitation and the structure of reality.
COVID-19 breakthrough infections and humoral immune response among BNT162b2 vaccinated healthcare workers in Malaysia
Creators: name: Yang, Su Lan
name: Ripen, Adiratna Mat
name: Leong, Chin Tho
name: Lee, Jen Ven
name: Yen, Chia How
name: Chand, Avinash Kumar
name: Koh, Karina
name: Rahim, Nur Aisyah Binti Abdul
name: Gokilavanan, Varaalakshmy
name: Mohamed, Nik Nur Eliza binti
name: Sevalingam, Raj Kumar A/L.
name: Sulaiman, Nadirah
name: bin Ab Razak, Ahmad Kamil
name: Nor, Nurul Haslinda binti Mohd
name: Pong, Mei Kuan
name: Tai, Ket Yan
name: Toh, Valerie
name: Woon, Yuan Liang
name: Peariasamy, Kalaiarasu M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: The evaluation of breakthrough infection and humoral immunity responses are important outcomes for vaccination policy for healthcare staff. This prospective cohort study collected blood samples at 5-time points; before primary vaccine doses, and at 2, 10 and 24 weeks after BNT162b2 vaccination from 551 HCWs, between March and October 2021. We investigated the association between anti-spike-1 protein receptor-binding domain (anti-S1-RBD) antibody geometric mean titre (GMT) and breakthrough infections. Two weeks post-vaccination, the GMT of anti-S1-RBD antibodies was measured at almost maximum detectable value (3115 BAU/ml [95% CI, 3051–3180]); it decreased to 1486 BAU/ml (95% CI, 1371–1610) at 10 weeks; and to 315 BAU/ml (95% CI, 283–349) at 24 weeks. Prior COVID-19 infection and age significantly affected the antibody titres. Fifty-six participants, none of whom were COVID-19 convalescents, had breakthrough infections between 10 and 24 weeks post-vaccination. Before breakthrough infections, the GMT was not different between the breakthrough and non-breakthrough individuals. After infection, the GMT was significantly higher in individuals with breakthrough infections (2038 BAU/ml [95%CI, 1547–2685]), specifically in symptomatic breakthroughs, compared to those without infection (254 BAU/ml [95%CI, 233–278]). A notable surge in breakthrough infections among healthcare workers coincided with the emergence of the Delta variant and when BNT162b2-elicited antibody responses waned in 10–24 weeks (i.e. approximately 3–6 months). Post-breakthrough, the antibody response was boosted in individuals with symptomatic presentations, but not asymptomatic individuals. The study finding supports administering booster vaccination for healthcare staff, including those who recovered from asymptomatic breakthrough infection.