cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mitochondrial uncoupling and remodelling during caloric restriction: Implications for oxidative stress and aging
Creators: name: Estery, Carmen M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: The 'uncoupling to survive' theory suggests that mitochondrial uncoupling protects cells from reactive oxygen species (ROS), thereby slowing aging. Caloric restriction (CR) mitigates aging; mechanisms may involve mitochondrial remodelling such that ROS production is decreased. It is unclear how uncoupling protein 3 (UCP3) in skeletal muscle is involved. Objective: To characterize effects of short-term 40% CR in wildtype (Wt) and UCP3 transgenic (UCP3 Tg) mice that possess uncoupled mitochondria. Hypothesis: In an uncoupled system, CR provides no further ROS protection. Approaches: Muscle mitochondrial and whole body assessments of UCP3's contribution to uncoupling and oxidative stress. Results: UCP3 Tg mice had lower body (P<0.001) and muscle weight (P<0.01), increased energy expenditure (P=0.12), similar body composition, increased proton leak (P<0.05), and decreased ROS production (P<0.05). In Wt mice, 1 mo CR mitigated ROS production (P<0.05), increased proton leak (P<0.05), decreased oxidative capacity (P<0.01), and increased UCP3 (P<0.05) protein levels. Such changes were not observed in UCP3 Tg mice. Overall, findings indicate that uncoupling in muscle does not reflect a pre-adaptation to CR. Rather, uncoupling delays the adaptive mitochondrial remodelling normally induced by short-term CR.
Transmembrane domain orientation and neurotransmitter binding in the nicotinic acetylcholine receptor
Creators: name: Hill, Danny G
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Chemistry, Biochemistry.

description: The orientation of the hydrogen-deuterium exchange resistant "core" of the of the intact nicotinic acetylcholine receptor from Torpedo was studied using linear dichroism attenuated total reflectance infrared spectroscopy both in the presence and absence of the agonist Carb. Our results show that the hydrogen exchange resistant alpha-helical peptide hydrogens in the nAChR are preferentially oriented parallel to the bilayer normal, therefore, providing evidence for a predominantly alpha-helical transmembrane domain, and that there are no detectable net changes in orientation upon agonist-induced desensitization. We also examined the linear dichroism of lipid bands in spectra recorded from membranes both with and without the nAChR in order to accurately assess the effects of membrane film mosaic spread on the interpretation of the linear dichroism data. Our data also show that the mosaic spread of the reconstituted membrane films is greater than the mosaic spread observed with pure lipid films. Our work illustrates the importance of mosaic spread characterization when interpreting experimental order parameters in terms of molecular structure orientation. (Abstract shortened by UMI.)
Digital Qualifiziert - Hans Pongratz
Creators: name: (:Unkn) Unknown
Publisher: name: Max-Planck-Gesellschaft zur Förderung der Wissenschaften
Year: 2021

description: In dieser Episode sprechen wir mit Hans Pongratz. 10 Jahre lang hat er als geschäftsführender Vizepräsident und CIO die Digitale Hochschule TU München geprägt. Seit Oktober ist er Chief Architect bei der Stiftung Hochschulzulassung. In unserem Gespräch gibt er uns Einblicke in die verschiedenen Initiativen und Ansätze der TU München, digital zu sein. Er verrät uns auch, warum der IT support Jodel-Chats liest, wie wichtig auch in der digitalen Welt das menschliche ist und warum eine gute Fehlerkultur der Digitalisierung hilft. Quelle: www.soundcloud.com
Characterization of a novel prostaglandin endoperoxide H synthase-1 transcript and examination of prostaglandin endoperoxide H synthase-1 expression.
Creators: name: Plant, Matthew Hilton.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Chemistry, Biochemistry.

description: The prostaglandin endoperoxide H synthase (PGHS) enzyme plays a pivotal role in the prostanoid biosynthetic pathway because it catalyzes the formation of prostaglandin H2 (PGH2), the common precursor for prostanoids. The object of my research is to characterize a novel PGHS transcript and to examine the mechanisms that regulate PGHS-1 gene expression. By Northern blotting with the entire hPGHS-1 coding region, 2.8 kb and 5.1 kb transcripts as well as a novel 4.5 kb transcript were detected in the human megakaryoblastic cell line, MEG-01. A non-canonical polyadenylation signal (AAGAAA) and a cleavage site (CA) were found and could generate the 4.5 kb PGHS-1 transcript. A commercial RNA dot blot with 50 different human tissues, showed a strong signal for the 4.5 kb PGHS-1 transcript in the bladder and appendix. Subsequent hybridization of a multiple tissue Northern blot detected 2.8, 4.5 and 5.1 kb transcripts in the bladder, indicating the 4.5 kb PGHS-1 transcript is not an artifact of the MEG-01 cell line. Treatment of MEG-01 cells with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) elevated PGHS-1 gene expression. The pattern of PGHS-1 mRNA and protein expression in MEG-01 cells after TPA treatment did not match. From our results, increased mRNA stability could not be determined because control and TPA treated PGHS-1 mRNA levels remained elevated for at least 8 hrs after treatment with inhibitors of transcription (Actinomycin-D and 5,6-Dichlorobenzimidazole Riboside). The effect of TPA of treatment on PGHS-1 mRNA levels disappeared after treatment with the protein synthesis inhibitor cycloheximide, indicating the increases in PGHS-1 mRNA levels involves de novo protein synthesis. (Abstract shortened by UMI.)
Abschwächung von klimabedingten Naturkatastrophen
Creators: name: Doyle, Ulrike
name: Ristow, Michael
name: Vohland, Katrin
Publisher: name: My University
Year: 2014

description: Die aktuelle Klimaerwärmung führt zu mehr Extremwetterereignissen, und diese können Naturkatastrophen auslösen. Die Auswirkungen dieser klimabedingten Naturkatastrophen können sich verstärken, wenn Ökosysteme vom Menschen intensiv genutzt und umgestaltet wurden. Landnutzungen wie die intensivierte Landwirtschaft, Verkehrs- und Siedlungsbau, technischer Wasserbau oder manche Formen des Tourismus tragen dazu bei. Naturschutzfachliche Maßnahmen innerhalb und außerhalb der Landnutzungen zur Abschwächung klimabedingter Naturkatastrophen sind sinnvoll. In diesem Artikel wird eine Anpassung von Strategien für den Naturschutz gefordert, die sich beiden Herausforderungen - Klimawandel und anthropogener Überformung der Landschaft - gleichermaßen widmet, um die Funktionsfähigkeit der Natur im Hinblick auf die Minderung der Auswirkungen von Naturkatastrophen zu erhalten.
Quelle: http://www.kohlhammer.de/
Russian Information Operations
Creators: name: Morrison, Sarah
Publisher: name: Swinburne
Year: 2024

description: Russian Information Operations examines the historical development of Russian information operations from 1989 to 2021, paying particular attention to the role technology, specifically the Internet and social media networks (SMNs), has played in developing these campaigns. The development of Russian information operations is a contemporary issue due to Russian disinformation campaigns' perceived effect on targeted countries, such as the US, in 2016 during the presidential election. The research demonstrates that Russian information operations continuously evolve and adapt to deployed information campaigns' successes and failures. Furthermore, the Internet, particularly SMNs, have added a ‘sticky’ element to information operations.
title: Fiabilidad y utilidad del estudio ecográfico en la valoración anatómica de la hernia inguinocrural.
Creators: name: Belda Serrano, Jesús Antonio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Hernia
subject: Surgery
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Abdomen

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
El diagnóstico específico de las hernias inguinocrurales es la base de unos buenos resultados quirúrgicos,
pues permite realizar una estrategia quirúrgica previa a la intervención.
El objetivo de este estudio es establecer mediante la...
Duftkerzen und Duftstäbchen: gemütlich oder gefährlich?
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2023

description: Gerade in der Winterzeit soll es im Wohnzimmer kuschelig und gemütlich werden. Dazu passen gut Duftkerzen, die nach Vanille oder Zimt riechen und Vorweihnachtsstimmung verbreiten! Aber für Allergiker sind einige der Duftstoffe bedenklich. Experten raten auch Gesunden zur Vorsicht, denn viele Duftstoffe sind noch nicht ausreichend erforscht. Und beim Verbrennen entstehen möglicherweise weitere Probleme. Quelle: https://www.ndr.de/
title: El tensor de difusión predice el déficit motor a largo plazo tras un infarto isquémico agudo
Creators: name: Puig Alcántara, Josep
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ischaemia / Infarction
subject: MR
subject: Neuroradiology brain

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
El déficit motor afecta aproximadamente al 50 % de los pacientes con infarto agudo cerebral agudo (IAC) con gran repercusión en la calidad de vida.
La identificación de variables predictivas de función motora podría permitir optimizar el manejo...
Factors Influencing Consumer Purchase Behavior towards Locally Manufactured Vehicles (Proton and Perodua)
Creators: name: Kuek, Michelle Shu Wun
Publisher: name: Swinburne
Year: 2024

description: This study primarily focuses on investigating and studying the factors that influence Malaysian car buyers’ purchase behavior towards locally manufactured vehicles, with a specific focus on our national automotive brands - Proton and Perodua. Theory of Reasoned Action and Theory of Planned Behavior are adopted to analyse the variables highlighted in this study - country-of-origin effects, price-quality association, value consciousness, perceived risk, and social influence. Two mediators - attitude towards product and brand reputation are also included to further mediate the relationships between the variables under study and the car buyers’ purchase intention and behavior.
Evaluation of a fentanyl drug checking service for clients of a supervised injection facility, Vancouver, Canada
Creators: name: Karamouzian, Mohammad
name: Dohoo, Carolyn
name: Forsting, Sara
name: McNeil, Ryan, 1982-
name: Kerr, Thomas
name: Lysyshyn, Mark
Publisher: name: BioMed Central
Year: 2018

description: Background: British Columbia, Canada, is experiencing a public health emergency related to opioid overdoses driven by consumption of street drugs contaminated with illicitly manufactured fentanyl. This cross-sectional study evaluates a drug checking intervention for the clients of a supervised injection facility (SIF) in Vancouver. Methods: Insite is a facility offering supervised injection services in Vancouver’s Downtown East Side, a community with high levels of injection drug use and associated harms, including overdose deaths. During July 7, 2016, to June 21, 2017, Insite clients were offered an opportunity to check their drugs for fentanyl using a test strip designed to test urine for fentanyl. Results of the drug check were recorded along with information including the substance checked, whether the client intended to dispose of the drug or reduce the dose and whether they experienced an overdose. Logistic regression models were constructed to assess the associations between drug checking results and dose reduction or drug disposal. Crude odds ratios (OR) and 95% confidence intervals (CI) were reported. Results: About 1% of the visits to Insite during the study resulted in a drug check. Out of 1411 drug checks conducted by clients, 1121 (79.8%) were positive for fentanyl. Although most tests were conducted post-consumption, following a positive pre-consumption drug check, 36.3% (n = 142) of participants reported planning to reduce their drug dose while only 11.4% (n = 50) planned to dispose of their drug. While the odds of intended dose reduction among those with a positive drug check was significantly higher than those with a negative result (OR = 9.36; 95% CI 4.25–20.65), no association was observed between drug check results and intended drug disposal (OR = 1.60; 95% CI 0.79–3.26). Among all participants, intended dose reduction was associated with significantly lower odds of overdose (OR = 0.41; 95% CI 0.18–0.89). Conclusions: Although only a small proportion of visits resulted in a drug check, a high proportion (~ 80%) of the drugs checked were contaminated with fentanyl. Drug checking at harm reduction facilities such as SIFs might be a feasible intervention that could contribute to preventing overdoses in the context of the current overdose emergency.
Rekombinase-induzierte Mutationen in soliden Tumoren des Kindesalters
Creators: name: Henssen, Anton George
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: pediatric oncology
subject: transposons
subject: PGBD5
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In dieser Habilitationsschrift werden fünf Publikationen vorgestellt, die sich mit der Frage befassen, welche Mutationsarten sich in Tumoren des Kindesalters finden lassen und wie Transposasen zu deren Entstehung beitragen könnten.
title: Osteocondromatosis craneal: presentación radiológica rara de una patología habitual en otras localizaciones.
Creators: name: Pérez Sánchez, Pablo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Presentación de varios casos de patología tumoral benigna extremadamente rara en localización cráneo-facial (condromatosis sinovial en articulación témporomandibular,
osteocondroma endocraneal y encondroma en cóndilo mandibular),
cuya...
TAP: a targeted clinical genomics pipeline for detecting transcript variants using RNA-seq data
Creators: name: Chiu, Readman
name: Nip, Ka M
name: Chu, Justin
name: Birol, Inanc
Publisher: name: BioMed Central
Year: 2018

description: Background: RNA-seq is a powerful and cost-effective technology for molecular diagnostics of cancer and other diseases, and it can reach its full potential when coupled with validated clinical-grade informatics tools. Despite recent advances in long-read sequencing, transcriptome assembly of short reads remains a useful and cost-effective methodology for unveiling transcript-level rearrangements and novel isoforms. One of the major concerns for adopting the proven de novo assembly approach for RNA-seq data in clinical settings has been the analysis turnaround time. To address this concern, we have developed a targeted approach to expedite assembly and analysis of RNA-seq data. Results: Here we present our Targeted Assembly Pipeline (TAP), which consists of four stages: 1) alignment-free gene-level classification of RNA-seq reads using BioBloomTools, 2) de novo assembly of individual targets using Trans-ABySS, 3) alignment of assembled contigs to the reference genome and transcriptome with GMAP and BWA and 4) structural and splicing variant detection using PAVFinder. We show that PAVFinder is a robust gene fusion detection tool when compared to established methods such as Tophat-Fusion and deFuse on simulated data of 448 events. Using the Leucegene acute myeloid leukemia (AML) RNA-seq data and a set of 580 COSMIC target genes, TAP identified a wide range of hallmark molecular anomalies including gene fusions, tandem duplications, insertions and deletions in agreement with published literature results. Moreover, also in this dataset, TAP captured AML-specific splicing variants such as skipped exons and novel splice sites reported in studies elsewhere. Running time of TAP on 100–150 million read pairs and a 580-gene set is one to 2 hours on a 48-core machine. Conclusions: We demonstrated that TAP is a fast and robust RNA-seq variant detection pipeline that is potentially amenable to clinical applications. TAP is available at http://www.bcgsc.ca/platform/bioinfo/software/pavfinder
The molecular mechanism for the regulation of CD44 expression and generation of hyaluronan-adhesive CD44 in human monocytic cells and human B cells
Creators: name: Gee, Katrina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.
subject: Health Sciences, Immunology.

description: Adhesion molecules are vital in cell-cell and cell-extracellular matrix interactions. The regulation of adhesion molecule expression and activity plays a critical role in the physiology of many immunological events under both physiological and pathophysiological conditions. Among the many adhesion proteins, the CD44 family of cell adhesion glycoproteins, is an important mediator in events such as tumorigenesis and metastasis, cell migration, angiogenesis, wound healing, and inflammatory responses. The regulation of CD44 expression as well as activation of binding to its ligand, hyaluronan (HA), are tightly regulated phenomena. The molecular mechanisms and cell signaling events behind the regulation of CD44 expression and HA binding events are not well understood. In this study, I examined the regulation of CD44 expression and HA binding in two models systems: human monocytic cells and human B cells. LPS, a bacterial cell wall component, regulates CD44 expression and may modulate CD44-mediated biological effects in monocytic cells during inflammation and immune responses. In this study, I show that in normal human monocytes, LPS and LPS-induced cytokines IL-10 and TNF-alpha enhance CD44 expression. To delineate the mechanism underlying LPS-induced CD44 expression, I investigated the role of mitogen-activated protein kinases (MAPK), p38, p42/44 extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) by employing specific inhibitors. I demonstrate the partial involvement of p38 MAPK in TNF-alpha-induced CD44 expression in both monocytes and the promonocytic THP-1 cell line. However, neither p38 nor p42/44 MAPKs were involved in IL-10-induced CD44 expression in monocytes. (Abstract shortened by UMI.)
title: Aspectos Radiológicos de la Esterilización Tubárica Histeroscópica mediante dispositivo ESSURE.
Creators: name: Garcia Nieto, Juan Carlos
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: Genital / Reproductive system female
subject: Conventional radiography
subject: Ultrasound
subject: Hysterosalpingography

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Tradicionalmente los procedimientos radiológicos han ido encaminados a preservar la fertilidad en la población general,
ateniéndose a las normas de Radioprotección.
Por otro lado,
las técnicas de imagen en radiología,
fundamentalmente la...
Supplementary document for Tailored micro-optical freeform holograms for integrated complex beam shaping - 4697959.pdf
Creators: name: Schmidt, Sören
name: Thiele, Simon
name: Toulouse, Andrea
name: Bösel, Christoph
name: Tieß, Tobias
name: Herkommer, Alois
name: Gross, Herbert
name: Giessen, Harald
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplmentary Tex-Document
title: Angiografía por TC en el estudio de la anatomía vascular abdominal y sus aplicaciones clínicas.
Creators: name: Garcia Roa, María Dolores
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Anatomy
subject: Vascular
subject: CT-Angiography
subject: CT
subject: Computer Applications-3D
subject: Computer Applications-Detection, diagnosis
subject: Diagnostic procedure
subject: Transplantation
subject: Ischaemia / Infarction
subject: Pathology

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
A menudo conocida tan solo superficialmente,
el estudio detallado de la anatomía vascular del abdomen,
tanto arterial como venosa,
es de importancia en la práctica radiológica diaria. El presente trabajo pretende ilustrar la anatomía vascular...
A qualitative investigation into the experiences and views of managers and senior leaders of the drivers of bullying in Victorian Public Sector workplaces
Creators: name: Quinn, Susan
Publisher: name: Swinburne
Year: 2024

description: This study examines the gap between incidences of bullying behaviours and initiatives to address the behaviours. The study does not seek to reframe the description of the behaviour, to contemplate it as an OH&S or a workplace wellbeing issue. It seeks to focus on the leaders of VPS organisations, to examine managers’ and senior leaders’ insights into the drivers of bullying behaviours. Their insights are from the point of view of a decision maker and influencer of the workplace culture, in particular what behaviour is acceptable and unacceptable.
title: Malformaciones vasculares pulmonares: utilidad del TCMD en su diagnóstico. Empleo de TC angiografía, reconstrucciones multiplanares, MIP y volume rendering.
Creators: name: Sánchez Muñoz, María Encarnación
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Pathology
subject: Diagnostic procedure
subject: Computer Applications-Detection, diagnosis
subject: Computer Applications-3D
subject: CT-Angiography
subject: CT
subject: Vascular
subject: Thorax
subject: Lung

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Demostrar la utilidad del TCMD con el empleo de contraste intravenoso como modalidad de imagen no invasiva para el estudio de las anomalías vasculares pulmonares. Revisar la patología malformativa vascular pulmonar,
describir los principales...
title: Ring-down Vs Cola de cometa: dos artefactos al descubierto
Creators: name: Méndez Garrido, Sandra
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ultrasound
subject: Technical aspects
subject: Artifacts

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
OBJETIVO DOCENTE -Reconocer estos singulares artefactos en un estudio ecográfico. -Conocimiento de las bases físicas que los sustentan con el objeto de diferenciarlos entre sí. -Orientar la posible patología subyacente a través de la correcta...
title: TC DENTAL: hallazgos más allá de los implantes dentales
Creators: name: Solanas Alava, Susana
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT-High Resolution
subject: Head and neck

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar la técnica de la TC dental,
el post-procesado de los datos y la realización de las diferentes reconstrucciones. Describir los hallazgos patológicos benignos más comunes encontrados enlosestudios de TC dental,incluyendo...
Supplementary document for Tailored micro-optical freeform holograms for integrated complex beam shaping - 4697959.pdf
Creators: name: Schmidt, Sören
name: Thiele, Simon
name: Toulouse, Andrea
name: Bösel, Christoph
name: Tieß, Tobias
name: Herkommer, Alois
name: Gross, Herbert
name: Giessen, Harald
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplmentary Tex-Document
Calcium, actin and the spectrin skeleton: Responses to swelling and shrinking perturbations.
Creators: name: Herring, Tammy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Cell.

description: It was postulated that cells regulate their surface membrane in response to membrane tension gradients. Increases in membrane tension, brought about by swelling, should therefore elicit addition of membrane to the cell surface, whereas decreases in membrane tension, brought about by shrinking, should cause retrieval of excess surface membrane. If increased membrane tension increases membrane area via enhanced calcium dependent exocytosis, then (Ca) $\rm\sb{int}$ rather than membrane tension may be the primary signal used in surface area regulation. (Ca) $\rm\sb{int}$ in swelling molluscan neurons was measured by FURA-2 ratiometric microscopy using perturbations which induced vacuole-like dilations (VLDs). (Ca) $\rm\sb{int}$ was measured in either normal (3.5mM) or low (0.5$\mu$M) extracellular calcium. The small but statistically significant changes observed were well below the levels which would stimulate exocytosis. In BAPTA loaded neurons, resting (Ca) $\rm\sb{int}$ was about one-half its normal value and did not change with osmotic perturbations. BAPTA was therefore effective at chelating neuronal intracellular calcium. BAPTA loaded neurons, like control neurons yielded VLDs using either normal or low extracellular calcium. Neurons incubated in cytochalasin, a drug that promotes actin depolymerization, do not undergo VLD recovery. Microscopy studies into how neuronal F-actin responded to osmotic perturbations and how the F-actin is related to VLDs were initiated. In Lymnaea neurons that had swelled then reshrunk to form VLDs, F-actin rapidly reorganized around the VLDs. At the substrate, F-actin formed rings of newly constituted leading edge (filopodia and lamellipodia) that we termed actipodia. Microinjection of live molluscan neurons with fluorescent G-actin also indicated that F-actin could reorganize as actipodia around the VLD membrane within 5 minutes. Cytochalasin incubated neurons formed VLDs but no actipodia were observed in association with these VLDs. F-actin rich actipodia may be the structures which help the VLD pinch off from the substrate and therefore begin reinternalization of excess surface membrane. (Abstract shortened by UMI.)
A risk based assessment approach for chemical mixtures from wastewater treatment plant effluents
Creators: name: Finckh, Saskia
name: Beckers, Liza-Marie
name: Busch, Wibke
name: Von Der Ohe, Peter C.
Publisher: name: My University
Year: 2022
Subjects: Umweltrisikobewertung

description: In this study, 56 effluent samples from 52 European wastewater treatment plants (WWTPs) were investigated for the occurrence of 499 emerging chemicals (ECs) and their associated potential risks to the environment. The two main objectives were (i) to extend our knowledge on chemicals occurring in treated wastewater, and (ii) to identify and prioritize compounds of concern based on three different risk assessment approaches for the identification of consensus mixture risk drivers of concern. Approaches include (i) PNEC and EQS-based regulatory risk quotients (RQs), (ii) species sensitivity distribution (SSD)-based hazard units (HUs) and (iii) toxic units (TUs) for three biological quality elements (BQEs) algae, crustacean, and fish. For this purpose, solid-phase extracts were analysed with wide-scope chemical target screening via liquid chromatography high-resolution mass spectrometry (LC-HRMS), resulting in 366 detected compounds, with concentrations ranging from < 1 ng/L to > 100 Ìg/L. The detected chemicals were categorized with respect to critical information relevant for risk assessment and management prioritization including: (1) frequency of occurrence, (2) measured concentrations, (3) use groups, (4) persistence & bioaccumulation, and (5) modes of action. A comprehensive assessment using RQ, HU and TU indicated exceedance of risk thresholds for the majority of effluents with RQ being the most sensitive metric. In total, 299 out of the 366 compounds were identified as mixture risk contributors in one of the approaches, while 32 chemicals were established as consensus mixture risk contributors of high concern, including a high percentage (66%) of pesticides and biocides. For samples which have passed an advanced treatment using ozonation or activated carbon (AC), consistently much lower risks were estimated. © 2022 Authors
title: Divertículos  y su amplio espectro de presentación
Creators: name: Ibáñez Zubiarrain, Ane
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Diverticula
subject: Diagnostic procedure
subject: Contrast agent-other
subject: CT
subject: MR
subject: Conventional radiography
subject: Pelvis
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Planteamos un repaso delas principales caracteriíticas de losdivertículosen cuanto a su localización,
complicaciones y problemas dediagnóstico diferencial. Todos los órganos huecos,
pueden presentar divertículos y los veremostanto en la...
Supplementary document for Electro-optically tunable laser with ultra-low tuning power dissipation and nanosecond-order wavelength switching for coherent networks - 4698196.pdf
Creators: name: Ueda, Yuta
name: Shindo, Takahiko
name: Kanazawa, Shigeru
name: Fujiwara, Naoki
name: Ishikawa, Mitsuteru
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Mainy shows derivation of equation (1)
Flourishing Urban Communities: A study in city development for social policy makers, practitioners and citizen activists
Creators: name: Van Eymeren, Andre Marinus
Publisher: name: Swinburne
Year: 2024

description: The concept of urbanisation is vexed, focusing on infrastructure, buildings and monetary systems. In an effort to provide all these things for people, communities most affected by change are often left out of the process. The Hebraic concept of shalom provides a new anthropocentric lens through which to view development. Termed flourishing in this work, shalom has been put into dialogue with sustainability and operationalised through the creation of the Flourishing Framework®.
Supplementary document for Electro-optically tunable laser with ultra-low tuning power dissipation and nanosecond-order wavelength switching for coherent networks - 4698196.pdf
Creators: name: Ueda, Yuta
name: Shindo, Takahiko
name: Kanazawa, Shigeru
name: Fujiwara, Naoki
name: Ishikawa, Mitsuteru
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Mainy shows derivation of equation (1)
Supplementary document for Spatial images from temporal data - 4699089.pdf
Creators: name: Turpin, Alex
name: Musarra, Gabriella
name: Kapitany, Valentin
name: Tonolini, Francesco
name: Lyons, Ashley
name: Starshynov, Ilya
name: Villa, Federica
name: conca, enrico
name: Fioranelli, Francesco
name: Murray-Smith, Roderick
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplementary document
Sentinels of inequity: examining policy requirements for equity-oriented primary healthcare
Creators: name: Lavoie, Josée G
name: Varcoe, Colleen, 1952-
name: Wathen, C. Nadine
name: Ford-Gilboe, Marilyn
name: Browne, Annette J.
Publisher: name: BioMed Central
Year: 2018

description: Background: Non-government, not-for-profit community health centres (CHCs) play a crucial role within healthcare systems in fostering equity, acting both as direct providers of services and as sentinels of health and social inequity. In a study of an intervention to promote equity-oriented health care, we enlisted four diverse primary healthcare clinics with mandates to serve highly marginalized populations. All of these CHCs operate as not-for-profit, non-government organizations (NGOs), and have a marginal relationship financially and socially to other parts of the system. The purpose of this paper is to provide an analysis of the factors that shape how CHCs are able to carry out an equity mandate and, from this, to identify what is required at the level of policy to enhance capacity to provide equity-oriented health care. Methods: We systematically examined the clinics’ policy and funding contexts, and identified influences on the clinics’ capacities to promote equity-oriented health care. Results: We identified three key mechanisms of influence, each playing out against the backdrop of a contested and marginal position of CHCs within the health care system: a) accountability and performance frameworks; b) patterns of funding and allocation of resources, and c) pathways for emergent priorities. We examine these mechanisms, considering how each influenced the pursuit of equity, and propose policy directions to optimize the primary health care sectors’ capacity to support equity-oriented health care. Conclusions: Although this analysis is based on a study within a high-income country, we argue that because the dynamics between community health centres and broader healthcare systems are similar across national boundaries, the implications have applicability to low and middle-income countries.
Association of Oversized Tracheal Tubes and Cuff Overinsufflation With Postintubation Tracheal Ruptures
Creators: name: Sudhoff, Tobias H.
name: Seidl, Rainer O.
name: Estel, Barbara
name: Coordes, Annekatrin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives Postintubation tracheal ruptures (PTR) are rare but cause severe complications. Our objective was to investigate the tracheal pattern of injury resulting from cuff inflation of the tracheal tube, to study the two main factors responsible for PTR (cuff overinsufflation and inapplicable tube sizes), and to explain the context, why small women are particularly susceptible to PTR. Methods Experimental study performed on 28 fresh human laryngotracheal specimens (16 males, 12 females) within 24 hours post autopsy. Artificial ventilation was simulated by using an underwater construction and a standard tracheal tube. Tube sizes were selected according to our previously published nomogram. Tracheal lesions were detected visually and tracheal diameters measured. The influence of body size, sex difference and appropriate tube size were investigated according to patient height. Results In all 28 cases, the typical tracheal lesion pattern was a longitudinal median rupture of the posterior trachea. Appropriate tube sizes according to body size caused PTR with significantly higher cuff pressure when compared with oversized tubes. An increased risk of PTR was found in shorter patients, when oversized tubes were used. Sex difference did not have any significant influence. Conclusion This experimental model provides information about tracheal patterns in PTR for the first time. The model confirms by experiment the observations of case series in PTR patients, and therefore emphasizes the importance of correct tube size selection according to patient height. This minimizes the risk of PTR, especially in shorter patients, who have an increased risk of PTR when oversized tubes are used.
Supplementary document for Spatial images from temporal data - 4699089.pdf
Creators: name: Turpin, Alex
name: Musarra, Gabriella
name: Kapitany, Valentin
name: Tonolini, Francesco
name: Lyons, Ashley
name: Starshynov, Ilya
name: Villa, Federica
name: conca, enrico
name: Fioranelli, Francesco
name: Murray-Smith, Roderick
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Classical and Physical Optics

description: Supplementary document
Pandion pannonicus Kessler 2018
Creators: name: Horváth, Ida
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Accipitriformes
Pandionidae
Pandion
Pandion pannonicus

description: † Pandion pannonicus Kessler, 2018
Location and age: Máriahalom; Lower Miocene (MN16).
Material: phalanx ungualis, digit pedis II (Figure 2 /3).
Dimensions (mm): A—19.3, B—9.9, C—3.50, D—5.20, E—4.8.
Description: This fossil, like the previously identified bones of † Pandion pannonicus, is smaller than those of the currently known osprey. The tuberculum extensorium is oblique with a blunt end; the cotyla articularis has an asymmetrical outline; the neck of the tuberculum flexorium is short, the lower part is convex in the middle; the corpus phalangis is wide and curved and the apex phalangis is damaged. The dimensions of the fossil are 80% of those of the extant species. It is similar in size and shape to the holotype example described.
Comparative material: Pandion haliaetus (2010.222.1); Pandion pannonicus Kessler, 2018 (uncatalogued).
This material is catalogued, number:VER 2021. 72; the bones belong to the collection of the Hungarian Museum of Natural History.
description: Published as part of Horváth, Ida, 2025, New records of fossil bird bones from the Neogene in Hungary, pp. 327-342 in Zootaxa 5627 (2) on page 331, DOI: 10.11646/zootaxa.5627.2.5, http://zenodo.org/record/15326047
Identification of Artemis and PARP-1 interacting factors: A yeast two hybrid screening approach
Creators: name: Farzadfar, Rahin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: The genomic integrity of the cell is under the constant threat of DNA damage from endogenous and exogenous sources. In response to DNA damage mammalian cells elicit a highly complex, yet coordinated series of cellular responses, which are triggered by the detection of DNA lesions and ultimately lead to cell survival (DNA repair) or apoptosis. Artemis and PARP-1 are two proteins with significant implications in the various branches within the DNA damage response network. A series of yeast two hybrid screening (Y2H) experiments were conducted using both classical and interacting mating Y2H systems to find Artemis and PARP-1 interacting factors. The ATRX protein was identified as a putative interactor of Artemis, Caspase-7 and an "unkown" protein were identified as putative interactors of PARP-1 binding factors. In addition a rare case of false positives were identified and characterized. Furthermore, the strengths and limits of each Y2H system, as well as troubleshooting techniques developed to increase the efficiency of each system were thoroughly examined.
Beyond Diamonds: Embedding the Post-Colonial State in Botswana
Creators: name: Griffore, Anne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Political Science, General.

description: This study examines Botswana's resource based development course within the framework of developmental state theory. Botswana's path to growth and development challenges existing theories in development studies in that it has avoided the many facets of the natural resource curse, which has set the majority of Africa's resource abundant economies on a path of long-term economic underperformance and low levels of social development. What is most remarkable however, is that growth and development have advanced in Botswana with inclusion of its tribal associations into a modern state bureaucracy while maintaining stable state-society relations - a feat that has been largely unmatched by other countries in the in the developing world. This study will argue in line with the developmental state ethos, that growth and development have occurred in this Botswana as the result of the deliberate actions taken by the government to embed a post-colonial state in Batswana society in ways that have enabled the central government to engage in economic and social development projects and to construct the institutions necessary to realize its development aspirations. This has not only been apparent in the undertakings of the administration to attract and collaborate with international capital, but also in its efforts to mediate between various interest groups and create the institutional framework necessary to enable positive-sum state-society relations under democratic principles.
Supplementary document for The Dispersion Mapping of Whispering Gallery Mode Robust Polariton at Room-tempearture - 4699277.pdf
Creators: name: Chen, Zhiyang
name: Zheng, Huying
name: Zhu, Hai
name: Huang, Ying
name: Tang, Ziying
name: Wang, Yaqi
name: Wei, Haiyuan
name: Wang, Xianghu
name: Shen, Yan
name: Gui, Xuchun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental
Hypertension Assessment via ECG and PPG Signals: An Evaluation Using MIMIC Database
Creators: name: Liang, Yongbo
name: Chen, Zhencheng
name: Ward, Rabab Kreidieh
name: Elgendi, Mohamed
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Cardiovascular diseases (CVDs) have become the biggest threat to human health, and they are accelerated by hypertension. The best way to avoid the many complications of CVDs is to manage and prevent hypertension at an early stage. However, there are no symptoms at all for most types of hypertension, especially for prehypertension. The awareness and control rates of hypertension are extremely low. In this study, a novel hypertension management method based on arterial wave propagation theory and photoplethysmography (PPG) morphological theory was researched to explore the physiological changes in different blood pressure (BP) levels. Pulse Arrival Time (PAT) and photoplethysmogram (PPG) features were extracted from electrocardiogram (ECG) and PPG signals to represent the arterial wave propagation theory and PPG morphological theory, respectively. Three feature sets, one containing PAT only, one containing PPG features only, and one containing both PAT and PPG features, were used to classify the different BP categories, defined as normotension, prehypertension, and hypertension. PPG features were shown to classify BP categories more accurately than PAT. Furthermore, PAT and PPG combined features improved the BP classification performance. The F1 scores to classify normotension versus prehypertension reached 84.34%, the scores for normotension versus hypertension reached 94.84%, and the scores for normotension plus prehypertension versus hypertension reached 88.49%. This indicates that the simultaneous collection of ECG and PPG signals could detect hypertension.
Structural insights into TRPV2 activation by small molecules
Creators: name: Pumroy, Ruth A
name: Protopopova, Anna D
name: Fricke, Tabea C
name: Lange, Iris U
name: Haug, Ferdinand M
name: Nguyen, Phuong T
name: Gallo, Pamela N
name: Sousa, Bárbara B
name: Lopes Bernardes, Goncalo
name: Yarov-Yarovoy, Vladimir
name: Leffler, Andreas
name: Moiseenkova-Bell, Vera Y
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/535/1258/1259
/631/45/269/1153
/9/74
/101/28
article

description: Funder: U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
description: Abstract: Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising drug target. Here we present cryo-electron microscopy (cryo-EM) structures of rat TRPV2 in lipid nanodiscs activated by 2-aminoethoxydiphenyl borate (2-APB) and propose a TRPV2-specific 2-ABP binding site at the interface of S5 of one monomer and the S4-S5 linker of the adjacent monomer. In silico docking and electrophysiological studies confirm the key role of His521 and Arg539 in 2-APB activation of TRPV2. Additionally, electrophysiological experiments show that the combination of 2-APB and cannabidiol has a synergetic effect on TRPV2 activation, and cryo-EM structures demonstrate that both drugs were able to bind simultaneously. Together, our cryo-EM structures represent multiple functional states of the channel, providing a native picture of TRPV2 activation by small molecules and a structural framework for the development of TRPV2-specific activators.
Palaeocryptonyx hungaricus Janossy 1991
Creators: name: Horváth, Ida
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Galliformes
Phasianidae
Palaeocryptonyx
Palaeocryptonyx hungaricus

description: † Palaeocryptonyx hungaricus Jánossy, 1991 (syn: † Eurobambusicola turolicus Zelenkov, 2016)
Location and age: Beremend 26; Lower Pliocene (MN15).
Material: a proximal left coracoid fragment (omal part) (Figure 2 /4).
Dimensions (in mm): coracoid: C—5.5–5.9, D—3.3–3.5, E—3.0–3.2.
Description: similar to Gallus bones, quail size.
Previous records of the taxon—sites and their age: Rátka, Upper Miocene (MN 12–13) (Kessler 2009b)— complete skeleton without skull; Polgárdi 4, 5, Upper Miocene (MN 13) (Jánossy 1991, 1995); Beremend 26, Lower Pliocene (MN 15) (Kessler 2009b), Beremend 17, 18 Lower Pleistocene (Q1) (Jánossy 1992, 1996). Mátraszőlős 3, Middle Miocene (Horváth 2023). Other than the above, no other sites have been reported. Along with other members of the genus, Mlíkovskỳ (2002) assigned Palaeocryptonyx hungaricus to † Alectoris donnezani (Depéret, 1892), while Zelenkov (2016) renamed it as Eurobambusicola turolicus.
This material is not catalogued, it belongs to the Chapel of Reconciliation in Beremend and will be catalogued in their collection.
description: Published as part of Horváth, Ida, 2025, New records of fossil bird bones from the Neogene in Hungary, pp. 327-342 in Zootaxa 5627 (2) on page 331, DOI: 10.11646/zootaxa.5627.2.5, http://zenodo.org/record/15326047
Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating
Creators: name: Keil, Julian
name: Romero, Yadira Roa
name: Balz, Johanna
name: Henjes, Melissa
name: Senkowski, Daniel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: inter-trial coherence
subject: power
subject: gamma-band
subject: alpha-band
subject: phenotype
subject: cluster analysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Oscillatory activity in neural populations and temporal synchronization within these populations are important mechanisms contributing to perception and cognition. In schizophrenia, perception and cognition are impaired. Aberrant gating of irrelevant sensory information, which has been related to altered oscillatory neural activity, presumably contributes to these impairments. However, the link between schizophrenia symptoms and sensory gating deficits, as reflected in oscillatory activity, is not clear. In this electroencephalography study, we used a paired-stimulus paradigm to investigate frequency-resolved oscillatory activity in 22 schizophrenia patients and 22 healthy controls. We found sensory gating deficits in patients compared to controls, as reflected in reduced gamma-band power and alpha-band phase synchrony difference between the first and the second auditory stimulus. We correlated these markers of neural activity with a five-factor model of the Positive and Negative Syndrome Scale. Gamma-band power sensory gating was positively correlated with positive symptoms. Moreover, alpha-band phase synchrony sensory gating was negatively correlated with negative symptoms. A cluster analysis revealed three schizophrenia phenotypes, characterized by (i) aberrant gamma-band power and high positive symptoms, (ii) aberrant alpha-band phase synchrony, low positive, and low negative symptom scores or (iii) by intact sensory gating and high negative symptoms. Our study demonstrates that aberrant neural synchronization, as reflected in gamma-band power and alpha- band phase synchrony, relates to the schizophrenia psychopathology. Different schizophrenia phenotypes express distinct levels of positive and negative symptoms as well as varying degrees of aberrant oscillatory neural activity. Identifying the individual phenotype might improve therapeutic interventions in schizophrenia.
Surface engineering of hybrid joints for sub-assembly
Creators: name: Esfahani, Mahsa
Publisher: name: Swinburne
Year: 2024

description: Service life of a self-pierced riveted joint is affected by various types of corrosion and fretting. Application of a coating to the self-pierce rivets can increase the corrosion and mechanical properties of the rivet and the joint. Nanocrystalline materials provide advanced properties to microcrystalline material therefore, in this thesis nanocrystalline zinc-tin coatings were synthetized as an advanced coating for self-piercing rivets and their corrosion and mechanical properties were compared with ultra-fine grained structured coatings.