cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Inside the Mind of “Poor” Emma: Austen’s Representation of Consciousness
Creators: name: Ellis, Maddie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: This piece examines Jane Austen's subtle use of focalization in "Emma" by confronting the gaps in terminology for it. I argue that  Austen's ability to slip into the minds of her characters and vocalize their thoughts constructs a holistic representation of human consciousness for a fictional character. A framework that explains this technique is called spontaneous psychological focalization. SPF takes into consideration analysis of individual sentences while signifying broader implications on character psychology, the idea of a subconscious, and Austen’s place in the history of the modern novel.
A domain free of the zeros of the partial theta function
Creators: name: Kostov, Vladimir Petrov
Publisher: name: arXiv
Year: 2022
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 26A06

description: We prove that for $q\in (0,1)$, the partial theta function $θ(q,x):=\sum _{j=0}^{\infty}q^{j(j+1)/2}x^j$ has no zeros in the closed domain $\{ \{ |x|\leq 3\} \cap \{${\rm Re}$x\leq 0\} \cap \{ |${\rm Im}$x|\leq 3/\sqrt{2}\} \} \subset \mathbb{C}$ and no real zeros $\geq -5$.
description: 2 figures
(502662) Nigel John Latham Wickham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502614) George Wickham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502611) Anne Wickham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Impact of guanine quadruplex formation on transcription and open chromatin regions
Creators: name: Rajee Ganesan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: DNA transcription is impacted by many regulatory inputs intrinsic and extrinsic to DNA sequence itself¹. One such regulation occurs through quadruplexes, also known as G4s. These are a family of alternative nucleic acid structures that are a core of stacked G-quartets (planar arrangement of four guanine bases) ². G4s have high structural stability under physiological conditions and affect transcription regulation, replication, and genomic stability². A variety of tools have been developed to find sequences where G4s could likely develop and cause transcriptional changes.  In this study, we use G4Hunter, a computational program, to identify regions where quadruplexes could form within specified genomic areas. Specifically, we used G4Hunter to predict quadruplex formation in promoter regions of genes whose expression and/or chromatin accessibility were significantly altered in bone-marrow derived macrophages (BMDMs) from the IL10KO colitis-prone mouse model upon stimulation by lipopolysaccharide (LPS), a bacterial-derived compound. This was completed to understand connections between changes in chromatin accessibility and gene expression in macrophages, which are key immune cells involved in intestinal inflammation, and how, or if, these changes are related to quadruplex formation.
(502612) David Wickham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Static Friction Coefficient Depends on the External Pressure and Block Shape due to Precursor Slip
Creators: name: Iwashita, Wataru
name: Matsukawa, Hiroshi
name: Otsuki, Michio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Amontons' law states that the maximum static friction force on a solid object is proportional to the loading force and is independent of the apparent contact area. This law indicates that the static friction coefficient does not depend on the external pressure or object shape. Here, we numerically investigate the sliding motion of a 3D viscoelastic block on a rigid substrate using the finite element method (FEM). The macroscopic static friction coefficient decreases with an increase in the external pressure, length, or width of the object, which contradicts Amontons' law. Precursor slip occurs in the 2D interface between the block and substrate before bulk sliding. The decrease in the macroscopic static friction coefficient is scaled by the critical area of the precursor slip before bulk sliding. A theoretical analysis of the simplified models reveals that bulk sliding results from the instability of the quasi-static precursor slip caused by velocity-weakening local friction. We also show that the critical slip area determines the macroscopic static friction coefficient, which explains the results of the FEM simulation.
description: 11 pages, 6 figures; Supplementary Information 9 pages, 3 figures; 2 ancillary files (Supplementary Video) attached
The Impact of Medicaid Expansion on Student Test Scores
Creators: name: McDonnell, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: This paper will focus on two separate provisions of the Affordable Care Act that incentivized many states to broaden either their child or adult Medicaid eligibility criteria to meet new federal guidelines. I used test score data from the Stanford Educational Data Archive (SEDA) and Medicaid eligibility data from the Kaiser Family Foundation to assess the impact of expanding these Medicaid eligibility thresholds on the standardized test scores of 3rd through 8th grade students. Using a combination of two-way fixed effects models and event studies, I ultimately found that neither expansion produced statistically significant effects across all students. However, I did find that the direction of the two eligibility expansion impacts tended to mirror each other, with the child expansion producing positive coefficients and the adult expansion producing negative coefficients. Additionally, I found that, unlike the child Medicaid expansion, there was a tremendous amount of variation in the magnitude and direction of the parental Medicaid expansion regression coefficients across different subgroups, with Black students being disproportionately affected. Finally, regardless of the direction of the relationship, the coefficients for math scores tended to be much larger than the coefficients for English scores. My results ultimately suggest that further adult Medicaid expansions are unlikely to meaningfully impact the short-term academic outcomes of all students; however, the impact of gaining coverage on the test scores of directly impacted students should be an area of future study.
Operational multipartite entanglement measures
Creators: name: Schwaiger, K.
name: Sauerwein, D.
name: Cuquet, M.
name: de Vicente, J. I.
name: Kraus, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce two operational entanglement measures which are applicable for arbitrary multipartite (pure or mixed) states. One of them characterizes the potentiality of a state to generate other states via local operations assisted by classical communication (LOCC) and the other the simplicity of generating the state at hand. We show how these measures can be generalized to two classes of entanglement measures. Moreover, we compute the new measures for pure few-partite systems and use them to characterize the entanglement contained in a three-qubit state. We identify the GHZ- and the W-state as the most powerful pure three-qubit states regarding state manipulation.
description: 12 pages (including supplemental material), 2 figures
New measurements of the transition to the normal state induced by high current densities in high-Tc superconductor microbridges under thermal smallness conditions
Creators: name: Doval, J. M.
name: Maza, J.
name: Torron, C.
name: Veira, J. A.
name: Tello, M.
name: Vidal, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We address here the superconductivity quenching under an external magnetic field of amplitudes up to 1 T and in the so-called "thermal smallness" condition, when the microbridge width becomes smaller than the thermal diffusion length of both the own superconductor and its refrigerant (the substrate, in the case of thin films), which breaks their thermal dimensional scaling. Our results further support that when the current perturbations have characteristic times in the millisecond range the quenching is due to thermal instabilities associated with regular (nonsingular) flux-flow, and they also suggest how to optimize the refrigeration of practical superconductors.
description: 8 pages, 2 figures
Quasiparticle scattering rate in a strongly polarised Fermi mixture
Creators: name: Christensen, Rasmus Søgaard
name: Bruun, Georg M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We analyse the scattering rate of an impurity atom in a Fermi sea as a function of momentum and temperature in the BCS-BEC crossover. The cross section is calculated using a microscopic multichannel theory for the Feshbach resonance scattering, including finite range and medium effects. We show that pair correlations significantly increase the cross section for strong interactions close to the unitarity regime. These pair correlations give rise to a molecule pole of the cross section at negative energy on the BEC side of the resonance, which smoothly evolves into a resonance at positive scattering energy with a non-zero imaginary part on the BCS side. The resonance is the analogue of superfluid pairing for the corresponding population balanced system. Using Fermi liquid theory, we then show that the low temperature scattering rate of the impurity atom is significantly increased due to these pair correlations for low momenta. We demonstrate that finite range and mass imbalance effects are significant for the experimentally relevant $^6$Li-$^{40}$K mixture, and we finally discuss how the scattering rate can be measured using radio-frequency spectroscopy and Bose-Fermi mixtures.
description: 7 pages, 5 figures
(502605) William Richard Todd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Effect of Gamma Irradiation on 5-Hydroxy-L-tryptophan and 5-Hydroxytryptamine
Creators: name: S. N. UPADHYAY
name: RAM PAL SINGH
name: ASHOK KUMAR GUPTA
name: A. GHOSE
Publisher: name: Zenodo
Year: 1988
Subjects: Gamma Irradiation
spectrophotometric observations
pyrrole group

description: Radiation Biology Department, Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Delhi-110 007
 Manuscript received 28 December 1987, revised 17 May 1988, accepted 28 May 1988 5-Hydroxy-L-tryptophan (HT) and 5-hydroxytryptamine (5-HT) in aqueous solutions show steady decrease in absorption intensities at their \(\lambda\) max at 207, 275 and the shoulder at 220 nm accompanied by decrease in pH when irradiated by gamma ray in the dose range of 100 —1500 Gy. The absorbance ratios at all the wave lengths clearly show that HT is much less sensitive to breakdown by gamma irradiation as compared to that of 5-HT. Significance of these changes have been discussed.
A novel approach for modeling the non-Newtonian behavior of simple liquids: application to liquid water viscosity from low to high shear rates
Creators: name: Aitken, Frédéric
name: Volino, Ferdinand
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The aim of this paper is to present a modeling for the rheological behavior of simple liquids as a function of the amplitude of the imposed shear stress or strain. The elastic mode theory (Ref. 6) is first generalized to take into account the fact that during a flow experiment, mechanical energy is injected in a system initially at thermodynamic equilibrium. This generalized theory can be seen as a particular aspect of the general problem of perturbation by the measurement, associated with that of the coupling between fluctuation and dissipation. This generalization leads to a "finitary" character of the model. It is then combined with the inertial mode theory (Ref. 7). The formalism thus obtained allows to model the rheological behavior of liquids over a wide range of velocity gradients, including the intermediate narrow range corresponding to the Newtonian regime. As experimental tests, viscosity measurements with two kinds of moving rotor rheometers were performed. Only data obtained with liquid water at room temperature are presented and quantitatively analyzed here. It is also shown that liquid n-octane exhibits the same qualitative behaviors as those of liquid water. In the appendices, connection of this theory with quantum mechanics and turbulence phenomena are discussed, and the notion of viscous mass is introduced.
description: 46 pages, 23 figures, 8 tables, 3 appendices
(502607) Ann Porter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Follow-up Study with Writing Prompts
Creators: name: Freitas, Antonio
name: Araiza, Ashley
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: This study examines the extent to which people expect their written responses to writing prompts to convey their authentic selves to other people. This study follows up on our earlier findings concerning the extent to which people expect to behave authentically in a range of situations.
(502609) Edward Wickham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Description of High-Energy pp Collisions Using Tsallis Thermodynamics: Transverse Momentum and Rapidity Distributions
Creators: name: Marques, L.
name: Cleymans, J.
name: Deppman, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A systematic analysis of transverse momentum and rapidity distributions measured in high-energy proton - proton (pp) collisions for energies ranging from 53 GeV to 7 TeV using Tsallis thermodynamics is presented. The excellent description of all transverse momentum spectra obtained in earlier analyses is confirmed and extended. All energies can be described by a single Tsallis temperature of 68 +/- 5 MeV at all beam energies and particle types investigated (43 in total). The value of the entropic index, q, shows a wider spread but is always close to q approx 1.146. These values are then used to describe the rapidity distributions using a superposition of two Tsallis fireballs along the rapidity axis. It is concluded that the hadronic system created in high-energy p - p collisions between 53 GeV and 7 TeV can be seen as obeying Tsallis thermodynamics.
description: 19 pages 22 figures
No Smooth Spacetime in Lorentzian Quantum Cosmology and Trans-Planckian Physics
Creators: name: Matsui, Hiroki
name: Mukohyama, Shinji
name: Naruko, Atsushi
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In minisuperspace quantum cosmology, the Lorentzian path integral formulations of the no-boundary and tunneling proposals have recently been analyzed. But it has been pointed out that the wave function of linearized perturbations around a homogeneous and isotropic background is of an inverse Gaussian form and thus that their correlation functions are divergent. In this paper, we revisit this issue and consider the problem of perturbations in Lorentzian quantum cosmology by modifying the dispersion relation based on trans-Planckian physics. We consider two modified dispersion relations, the generalized Corley-Jacobson dispersion relation with higher momentum terms and the Unruh dispersion relation with a trans-Planckian mode cut-off, as examples. We show that the inverse Gaussian problem of perturbations in Lorentzian quantum cosmology is hard to overcome with the trans-Planckian physics modifying the dispersion relation at short distances.
description: 25 pages, 11 figures, v2: final published version
Role of the Primary Cilium in the Crosstalk Between Obesity and Cancer
Creators: name: Merlino, Jenna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Background: Defects in primary cilium cause ciliopathies, with links to both obesity and cancer. Obesity contributes to inflammation and downregulates anti-tumor immunity, generating a pro-tumor microenvironment and increasing the risk of breast cancer (BC) development and metastasis. Also, obesity affects cilium length, which could disrupt the essential role of the cilium in detecting extracellular cues, coordinating cell signaling responses, and regulating cell fate and mitochondrial function. However, the effect of obesity on ciliogenesis in cancer cells and the impact of cilium length and localization on the mitochondrial function of tumor cells are unclear. We sought to elucidate the impact of obesity on the presence, localization and function of primary cilium using murine models of triple-negative breast cancer (TNBC).
 
Methods: The presence of primary cilium in murine models of TNBC, including M28, M6, M6C, metM-Wnt-lung and E0771 cell lines was quantified by immunofluorescence analysis. To investigate the localization of the cilium, we developed metM-Wnt-lung cells expressing the ciliary protein Smo tagged to pH-luorin and utilized a two-color immunofluorescence assay. To analyze the impact of obesity on tumor ciliation we generated mammary tumors by orthotopic transplantation of murine metM-Wnt-lung or E0771 cells into the mammary fat pad of obese female mice. In mammary tumors, the enrichment of ciliary genes was evaluated using gene set enrichment analysis (GSEA) and the abundance of cilium using immunofluorescence.
 
Results: In M28 (weakly tumorigenic) cell cultures, 33% of the cells were ciliated, while in invasive (M6) and metastatic models (M6C, metM-Wnt-lung and E0771) the ciliation fluctuated between 5% and 20%. The presence and length of primary cilium was unaffected by serum deprivation. In vivo, obesity resulted in upregulation of 13/18 and 9/18 ciliary gene sets in metM-Wnt-lung and E0771 mammary tumors, respectively, compared to tumors developed in non-obese mice. The enrichment of these ciliary associated gene sets was contributed to by 389 genes in metM-Wnt-lung mammary tumors and 195 genes in E0771 mammary tumors, 168 of which were commonly enriched in both tumor types. Immunofluorescence analysis showed a significant increase in the number of cilia per area of the tumor in obese mice compared to non-obese mice. 
 
Conclusion: We established a proof-of-concept that murine mammary cancer cells express primary cilium and the presence of primary cilium is upregulated by obesity. The importance of primary cilium in cancer is emerging. Ongoing studies will reveal the localization of the cilium in cancer cells and its effects on mitochondrial function. We will elucidate mechanistic details of the role of primary cilium in the crosstalk between obesity and cancer metabolism.
(502606) John Latham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Fourientations and the Tutte Polynomial
Creators: name: Backman, Spencer
name: Hopkins, Sam
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C30, 05C31, 05C25, 05E40, 52C35, 14T05

description: A fourientation of a graph is a choice for each edge of the graph whether to orient that edge in either direction, leave it unoriented, or biorient it. Fixing a total order on the edges and a reference orientation of the graph, we investigate properties of cuts and cycles in fourientations which give trivariate generating functions that are generalized Tutte polynomial evaluations of the form \[(k+m)^{n-1}(k+l)^gT\left(\frac{αk + βl + m}{k+m},\frac{γk + l + δm}{k+l}\right)\] for $α,γ\in \{0,1,2\}$ and $β, δ\in \{0,1\}$. We introduce an intersection lattice of 64 cut-cycle fourientation classes enumerated by generalized Tutte polynomial evaluations of this form. We prove these enumerations using a single deletion-contraction argument and classify axiomatically the set of fourientation classes to which our deletion-contraction argument applies. This work unifies and extends earlier results for fourientations due to Gessel and Sagan, and results for partial orientations due to the first author, and the second author and David Perkinson, as well as results for total orientations due to many authors. We conclude by describing how these classes of fourientations relate to geometric, combinatorial, and algebraic objects including bigraphical arrangements, cycle-cocycle reversal systems, graphic Lawrence ideals, Riemann-Roch theory for graphs, zonotopal algebras, and the reliability polynomial.
description: 59 pages, 11 figures; v2: minor updates, v3: major updates
(502597) James Wodehouse
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Impact of anti-inflammatory Sulindac in ameliorating lung metastasis of obesity-driven breast cancer
Creators: name: Wang, Sylvia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Obesity causes chronic inflammation, which is associated with increased breast cancer risk and increased breast cancer metastasis. Prior studies showed that diet-induced obesity (DIO) increased mammary tumor metastasis burden in mice injected with murine cancer cell lines of triple negative breast cancer. Additionally, separate studies have shown that treatment of tumor-bearing mice with non-steroidal anti-inflammatory drugs (NSAIDs) reduced tumor burden through COX-2 inhibition. Nevertheless, the mechanisms of how both obesity and chronic inflammation act in concert to promote breast cancer metastasis are unclear and therapeutic interventions to reduce poor outcomes warrant more intensive research. We hypothesize that Sulindac supplementation reduces the lung metastatic burden in DIO mice injected with E0771 mammary cell line. To test this hypothesis, we used a mouse model of obesity and breast cancer to test the impact of the anti-inflammatory Sulindac on lung metastasis. This research will measure the effect of Sulindac on obesity-driven inflammation and metastatic burden. The result from this study will provide novel treatment strategies for mitigating the risk that obesity poses to cancer development. Treatment with Sulindac decreased body weights of mice in both control and DIO diet conditions. No significant differences were observed regarding the lung metastatic burden between the control, control+Sulindac, DIO, and DIO+Sulindac diet conditions. However, our DIO+Sulindac group had the largest lung weights and smallest GFP intensity of all dietary groups, indicating some role of Sulindac in affecting lung metastatic burden. This study suggests that there may be a link between obesity, inflammation, and lung metastatic burden in our metastatic mouse models. Sulindac supplementation may impact the role of inflammation in obese mice. Further investigation into improving the lung metastatic model is needed to test the effectiveness of various combinatorial treatment therapies on breast cancer metastasis in obesity.
Health workers’ roles, challenges, and suggestions for improving antenatal care in Oromia, Ethiopia
Creators: name: Worku, Beamlak
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Abstract
Experiences and perceptions of health workers, as well as their motivations and intentions for their reason to work, are important factors considering antenatal care (ANC) for pregnant women. Providing proper maternal and child healthcare during pregnancy, delivery, and postpartum are the best ways to reduce proper maternal and neonatal morbidity and mortality. Speaking with healthcare providers to understand how best to support them is pertinent in providing the best possible care.1 Twenty-one interviews with health providers and volunteers in two districts in Ethiopia were conducted to examine their perceptions of their respective roles and the roles of others, as well as what they found satisfying and challenging about their respective roles, and what recommendations they have to improve antenatal care within their roles. 15 of these interviews were analyzed using a ground theory approach through Atlas.ti software. Most providers and volunteers were satisfied with their overall jobs, but also had many suggestions for change.
(502603) Aileen [White]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Geometry of charged rotating discs of dust in Einstein-Maxwell theory
Creators: name: Rumler, David
name: Kleinwächter, Andreas
name: Meinel, Reinhard
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Within the framework of Einstein-Maxwell theory geometric properties of charged rotating discs of dust, using a post-Newtonian expansion up to tenth order, are discussed. Investigating the disc's proper radius and the proper circumference allows us to address questions related to the Ehrenfest paradox. In the Newtonian limit there is an agreement with a rotating disc from special relativity. The charged rotating disc of dust also possesses material-like properties. A fundamental geometric property of the disc is its Gaussian curvature. The result obtained for the charged rotating disc of dust is checked by additionally calculating the Gaussian curvature of the analytic limiting cases (charged rotating) Maclaurin disc, electrically counterpoised dust-disc and uncharged rotating disc of dust. We find that by increasing the disc's specific charge there occurs a transition from negative to positive curvature.
description: 26 pages, 16 figures; v4: correction in section 5.6
Reddening, Distance, and Stellar Content of the Young Open Cluster Westerlund 2
Creators: name: Hur, Hyeonoh
name: Park, Byeong-Gon
name: Sung, Hwankyung
name: Bessell, Michael S.
name: Lim, Beomdu
name: Chun, Moo-Young
name: Sohn, Sangmo Tony
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present deep $UBVI_C$ photometric data of the young open cluster Westerlund 2. An abnormal reddening law of $R_{V,cl}=4.14\pm0.08$ was found for the highly reddened early-type members ($E(B-V)\geq 1.45$), whereas a fairly normal reddening law of $R_{V,fg}=3.33\pm0.03$ was confirmed for the foreground early-type stars ($E(B-V)_{fg}<1.05$). The distance modulus was determined from zero-age main-sequence (ZAMS) fitting to the reddening-corrected colour-magnitude diagram of the early-type members to be $V_0-M_V=13.9\pm0.14$ (random error) $_{-0.1}^{+0.4}$ (the upper limit of systematic error) mag ($d = 6.0 \pm 0.4 _{-0.3}^{+1.2}$ kpc). To obtain the initial mass function, pre-main-sequence (PMS) stars were selected by identifying the optical counterparts of Chandra X-ray sources and mid-infrared emission stars from the Spitzer GLIMPSE source catalog. The initial mass function shows a shallow slope of $Γ=-1.1 \pm 0.1$ down to $\log m = 0.7$. The total mass of Westerlund 2 is estimated to be at least 7,400 $M_{\odot}$. The age of Westerlund 2 from the main-sequence turn-on and PMS stars is estimated to be $\lesssim$ 1.5 Myr. We confirmed the existence of a clump of PMS stars located $\sim1$ arcmin north of the core of Westerlund 2, but we could not find any clear evidence for an age difference between the core and the northern clump.
description: 25 pages, 22 figures, 6 tables, accepted for publication in MNRAS
Three- and Four-Point Functions in CPT-Even Lorentz-Violating Scalar QED
Creators: name: Altschul, B.
name: Brito, L. C. T.
name: Felipe, J. C. C.
name: Karki, S.
name: Lehum, A. C.
name: Petrov, A. Yu.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The renormalization of quantum field theories usually assumes Lorentz and gauge symmetries, besides the general restrictions imposed by unitarity and causality. However, the set of renormalizable theories can be enlarged by relaxing some of these assumptions. In this work, we consider the particular case of a CPT-preserving but Lorentz-breaking extension of scalar QED. For this theory, we calculate the one-loop radiative corrections to the three- and four-point scalar-vector vertex functions, at the lowest order in the Lorentz violation parameters; and we explicitly verify that the resulting low-energy effective action is compatible with the usual gauge invariance requirements. With these results, we complete the one-loop renormalization of the model at the leading order in the Lorentz-violating parameters.
description: 18 pages, matches published version
RAFT Step-growth Polymerization with Diacrylates: Noel Archer's Undergraduate Honor's Thesis
Creators: name: Noel Archer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Here we demonstrate RAFT step-growth polymerization with diacrylate monomers for the first time, expanding the scope of this methodology with a monomer family that is widely available. Acrylates are known to be fast homopropagating monomers, however, to date, RAFT step-growth polymerization has only been demonstrated with monomers that bears low rate of homopropagation to favor the chain transfer process. We initially identified chain transfer agent (CTA) that rapidly yields Single monomer unit (SUMI) CTA adducts with a model acrylate monomer. We successfully achieved RAFT step growth polymerization of this bifunctional CTA with diacrylate, yielding linear polymer backbones. In addition, we demonstrate incorporation of functionality tethered through the bifunctional CTA for the first time. Selective cleavage of this moiety in molecular brushes grafted from this backbone resulted in well-defined unimolecular species that is consistent of two polymeric side chains. Significantly, this demonstrates synergy of RAFT process and step-growth, allowing facile synthesis of complex architecture with modular backbone.
Multiplicity in the Lupus & V1062 Sco young stellar populations
Creators: name: Briceno, Cesar
name: Tokovinin, Andrei
Publisher: name: Zenodo
Year: 2023
Subjects: Stars:Binaries, Stars:Young

description: Multiplicity statistics in populations of young stars is an important tool for gaining insight on the formation of stellar systems. In this presentation we report on the recent results of a Speckle interferometry study of 40 stars in the Lupus association and 60 members of the recently identified, nearby V1062 Sco group. Using an EMCCD high speed camera on the 4.1 m Southern Astrophysical Research telescope, we resolved 24 pairs at separations above 0.07 arcsec; we combined these detections with an additional 24 companions found in Gaia data at separations up to 30 arcsec. We recovered all known pairs and find a number of systems identified here for the first time. In the separation range from ~0.06 to 20 arcsec, we identify 20 binaries in Lupus with mass ratios above 0.3, for a multiplicity rate of 0.50+/-0.11. In contrast, the observed multiplicity in the V1062 Sco group is 14 binaries or a 0.24+/-0.07 fraction, lower than in Lupus (at a 2-sigma level). This lower companion fraction in the more dense V1062 Sco group is overall consistent with proposed scenarios in which multiplicity is higher in low stellar density populations. Other regions like Upper Scorpius also follow this trend.
(502604) Charlotte Todd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MeerKAT follow-up of enigmatic GLEAM 4-Jy (G4Jy) sources
Creators: name: Sejake, Precious K.
name: White, Sarah V.
name: Heywood, Ian
name: Thorat, Kshitij
name: Bester, Hertzog L.
name: Makhathini, Sphesihle
name: Fanaroff, Bernie
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the results from studying 140 radio sources in the GLEAM (GaLactic and Extragalactic All-sky MWA [Murchison Widefield Array]) 4-Jy (G4Jy) Sample. These sources were followed-up with MeerKAT to assess their radio morphology and enable host-galaxy identification, as existing radio images of 25 to 45-arcsec resolution do not provide sufficient information. We refer to these sources as the MeerKAT-2019 subset. The aim is to identify the host galaxy of these sources by visually inspecting the overlays comprising radio data from four surveys (at 150, 200, 843/1400, and 1300 MHz). Our morphological classification and host-galaxy identification relies upon the ~7-arcsec resolution images from MeerKAT (1300 MHz). Through the visual inspection of the overlays, 14 radio sources in the MeerKAT-2019 subset have wide-angle tail (WAT) morphology, 10 are head-tail, and 5 have X-, S-/Z-shaped morphology. Most of the remaining sources have the radio morphology of typical symmetric lobes. Of 140 sources, we find host galaxies for 98 sources, leaving 42 with no identified host galaxy. These 42 sources still have ambiguous identification even with higher resolution images from MeerKAT.
description: 20 pages, 16 figures, 4 tables. Published in MNRAS
Career Stage Moderates the Relationship Between Mental Health Severity and White Matter Integrity in Special Operations Forces Combat Soldiers
Creators: name: Dums, Emma
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Special Operations Forces (SOF) combat Soldiers are exposed to mild traumatic brain injury (mTBI) risk during training and combat operations. Service members who have sustained an mTBI may also experience various mental health issues. Neurophysiological changes from mTBI outlast clinical recovery including decreased structural integrity of white matter (WM) tracts in the brain. Therefore, using clinical tests to predict WM integrity could aid in assessing neurotrauma in SOF combat Soldiers. The purpose of this study was to determine how mTBI and career stage moderate the association between mental health symptom severity and WM tract integrity in SOF combat Soldiers. We reconstructed 40 WM tracts for 66 SOF Soldiers. Significant interaction effects of career stage were found in the corpus callosum, significant main effects of depression and anxiety symptom severity were found in the frontal aslant tract, a significant main effect of PTSD symptom severity was found in the uncinate fasciculus, and a significant main effect of later career stage was found in the superior longitudinal fasciculus and the corpus callosum.
New Implementation of an Equation-of-Motion Coupled-Cluster Damped-Response Framework with Illustrative Applications to Resonant Inelastic X-ray Scattering
Creators: name: Schnack-Petersen, Anna Kristina
name: Moitra, Torsha
name: Folkestad, Sarai Dery
name: Coriani, Sonia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We present an implementation of a damped response framework for calculating resonant inelastic X-ray scattering (RIXS) at the equation-of-motion coupled cluster singles and doubles (CCSD) and second-order approximate coupled cluster singles and doubles (CC2) levels of theory in the open-source program $e^T$. This framework lays the foundation for future extension to higher excitation methods (notably, the coupled cluster singles and doubles with perturbative triples, CC3) and to multilevel approaches. Our implementation adopts a fully relaxed ground state, and different variants of the core-valence separation projection technique to address convergence issues. Illustrative results are compared with those obtained within the frozen-core core-valence separated approach, available in Q-Chem, as well as with experiment. The performance of the CC2 method is evaluated in comparison with that of CCSD. It is found that, while the CC2 method is noticeably inferior to CCSD for X-ray absorption spectra, the quality of the CC2 RIXS spectra is often comparable to that of the CCSD level of theory, when the same valence excited states are probed. Finally, we present preliminary RIXS results for a solvated molecule in aqueous solution.
Assessing node risk and vulnerability in epidemics on networks
Creators: name: Rogers, Tim
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Which nodes are most vulnerable to an epidemic spreading through a network, and which carry the highest risk of causing a major outbreak if they are the source of the infection? Here we show how these questions can be answered to good approximation using the cavity method. Several curious properties of node vulnerability and risk are explored: some nodes are more vulnerable than others to weaker infections, yet less vulnerable to stronger ones; a node is always more likely to be caught in an outbreak than it is to start one, except when the disease has a deterministic lifetime; the rank order of node risk depends on the details of the distribution of infectious periods.
description: Note that Figure 2 does not appear in the final published version
(502594) Nathaniel F. Wodehouse
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Charged ultralong-range Rydberg trimers
Creators: name: Bosworth, Daniel J.
name: Hummel, Frederic
name: Schmelcher, Peter
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show that the recently observed class of long-range ion-Rydberg molecules can be divided into two families of states, which are characterised by their unique electronic structures resulting from the ion-induced admixture of quantum defect-split Rydberg $n$P states with different low-field seeking high-$l$ states. We predict that in both cases these diatomic molecular states can bind additional ground state atoms lying within the orbit of the Rydberg electron, thereby forming charged ultralong-range Rydberg molecules (ULRM) with binding energies similar to that of conventional non-polar ULRM. To demonstrate this, we consider a Rydberg atom interacting with a single ground state atom and an ion. The additional atom breaks the system's cylindrical symmetry, which leads to mixing between states that would otherwise be decoupled. The electronic structure is obtained using exact diagonalisation over a finite basis and the vibrational structure is determined using the Multi-Configuration Time-Dependent Hartree method. Due to the lobe-like structure of the electronic density, bound trimers with both linear and nonlinear geometrical configurations of the three nuclei are possible. The predicted trimer binding energies and excitation series are distinct enough from those of the ion-Rydberg dimer to be observed using current experimental techniques.
description: 11 pages, 7 figures