cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Primary care visits due to mental health problems and use of psychotropic medication during the COVID-19 pandemic in Finnish adolescents and young adults
Creators: name: Kuitunen, Ilari
name: Uimonen, Mikko M.
name: Ponkilainen, Ville T.
name: Mattila, Ville M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: Table S1. Included diagnostic codes based on the ICD-10 (International Classification of Diseases 10th version) and the grouping used in our study based on the diagnoses. Table S2. Included medicines based on the ATC (Anatomical therapeutic classification)
PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies
Creators: name: Hickey, John M.
name: Sharma, Nitya
name: Fairlamb, Max
name: Doering, Jennifer
name: Adewunmi, Yetunde
name: Prieto, Katherine
name: Costa, Giulia
name: Wizel, Benjamin
name: Levashina, Elena A.
name: Mantis, Nicholas J.
name: Julien, Jean-Philippe
name: Joshi, Sangeeta B.
name: Volkin, David B.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Circumsporozite protein (CSP), the most abundant surface protein in parasitic Plasmodium falciparum (Pf) sporozoite and an attractive target for malaria vaccine design, has been shown to induce protective humoral response in humans. In this work, we characterized and formulated a promising recombinant PfCSP immunogen (155) candidate consisting of two PfCSP epitopes (i.e. junction, NANP repeat) fused to H. pylori apoferritin forming a 24-mer nanoparticle. In addition, two N-linked glycans were engineered to mitigate possible anti-apoferritin immune responses, and a universal T-cell epitope was included to further enhance immunogenicity. Physicochemical characterization of the 155 antigen was performed including primary structure, post-translational modifications, conformational stability, and particle size. A competitive ELISA was developed to assess antigen binding to a PfCSP-specific mAb. The in vitro antigenicity of the 155 antigen was measured upon formulation with adjuvants, including aluminum-salts (i.e. AlhydrogelTM, Adju-PhosTM) and the TLR-9 agonist CpG 1018®, when freshly combined and after storage at different temperatures over 3 months. The in vivo immunological impact of various adjuvanted formulations of the 155 antigen was investigated in mice. The results support the formulation of 155 with AlhydrogelTM + CpG 1018® adjuvants as a promising recombinant malaria vaccine candidate from both a pharmaceutical and immunological perspective.
Demographics and clinical burden of disease among RSV-hospitalized older adults in Italy: A retrospective cohort study
Creators: name: Puggina, Anna
name: Dovizio, Melania
name: Domnich, Alexander
name: Marijam, Alen
name: Veronesi, Chiara
name: Rizzo, Caterina
name: Vicentini, Marta
name: Degli Esposti, Luca
name: Calabrò, Giovanna Elisa
name: Fonseca, Maria João
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection and can lead to severe disease in older adults or those with comorbidities. This analysis aims to evaluate the demographic and clinical burden of RSV hospitalizations among older adults in Italy and inform potential preventative strategies. Adults aged ≥50 years with ≥1 hospitalization discharge diagnosis for RSV from 2010 to 2021 were included. Demographic characteristics before the first RSV hospitalization and clinical outcomes during this hospitalization and the 12 months following are described. Of the 243 patients, mean (SD) age was 73.7 (13.1) years, 40.7% were male, and the most common comorbidities were chronic obstructive pulmonary disease (37.9%), diabetes (21.8%), and heart failure (15.2%). Mean length of index hospitalization was 17.0 days, during which 9.1% of patients died. At index or during the 12-month follow-up, 5.8% had an intensive care unit admission, 61.3% were prescribed antibiotics, 8.2% had a stroke, and 3.3% had an acute myocardial infarction. During the 12-month follow-up, approximately, half of patients experienced worsening of preexisting comorbidities, with notable rates of re-hospitalization and mortality (44.4% and 29.6%). This study shows a high clinical burden of RSV among older adults in Italy, emphasizing a need for improved RSV surveillance, and may guide policymakers and healthcare providers in making informed recommendations for, and implementation of, RSV vaccination in Italy.
Children and young people with perinatal HIV in Europe: epidemiological situation in 2014 and implications for the future
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: Europe
subject: HIV
subject: Surveillance
subject: adolescent
subject: cohort
subject: paediatric
subject: 610 Medizin

description: Accurate ascertainment of the number of children living with human immunodeficiency virus (HIV) is important to plan paediatric and adolescent health services. In Europe, the first generation of perinatally HIV-infected survivors are transferring to adult care and their health needs are unknown. We undertook an online survey of HIV cohort studies participating in the EuroCoord Network of Excellence to ascertain the number of perinatally HIV-infected (pHIV) patients included, to compare it with those published by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) and to assess the ability of countries to follow up pHIV patients after transfer to adult care. At the end of 2013, 16 countries in EuroCoord reported 8,229 pHIV patients in follow-up in cohorts, compared with 5,160 cumulative diagnoses reported by the ECDC in the same area. Follow-up of pHIV patients after transfer to adult care varied. It is likely that the number of diagnoses of perinatal HIV reported to ECDC is an underestimate, although this varies by country. Further work is needed to refine estimates and encourage follow-up in adult HIV cohorts to investigate long-term outcomes and improve the care of the next generation of children with HIV.
Expectancy in Pelvic Organ Prolapse Surgery and Recovery: Factor Structure and Validity
Creators: name: Touza, Kaitlin
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Clinical psychology

description: Women describe pelvic organ prolapse (POP) surgery as difficult to recover from. Expectancy is related to recovery in other surgeries but has not been examined in POP. There is no established measure of surgery expectancy or utility in women with POP. This research had four aims: 1) to establish the factor structure of a new measure of POP surgery expectancy; 2) to establish predictive validity of the expectancy measure by examining its ability to predict self-rated recovery over time; 3) to establish concurrent validity of the expectancy measure; and 4) to examine the ability of utility to predict additional variance in recovery. Exploratory factor analysis revealed a three-factor solution. Factors are conceptualized as: 1) Bladder/Bowel Function; 2) Sexual Function; and 3) Physical Function. Bladder/Bowel Function correlated with optimism and self-efficacy (r = .17, p = .03 and r = .27, p = .00, respectively). Physical Function was predictive of recovery at 42 days (standardized coefficient = .25; p < .05). However, these factors were generally poor and inconsistent predictors of recovery. Utility did not predict additional variance in recovery. Potential explanations for the poor predictive ability of the measure are discussed. The development of a measure that amends these limitations may still be beneficial. Further, exploring and establishing the relationship between surgery expectancy, utility, and recovery may guide physician-patient discussions and lead to improved surgical outcomes.
Mobile Enhancement of Motivation in Schizophrenia: A Pilot Trial of a Personalized Text-Message Intervention for Motivation Deficits
Creators: name: Luther, Lauren
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Clinical psychology

description: Motivation deficits remain an unmet treatment need in schizophrenia. Recent preclinical research has identified novel mechanisms underlying motivation deficits, namely impaired effort-cost computations and reduced future reward-value representation maintenance, that may serve as more effective treatment targets to improve motivation. The main aim of this study was to test the feasibility and preliminary effectiveness of a translational mechanism-based intervention, MEMS (Mobile Enhancement of Motivation in Schizophrenia), which leverages mobile technology to target these mechanisms with text-messages. Fifty-six participants with a schizophrenia-spectrum disorder were randomized to MEMS (n = 27) or a control condition (n = 29). All participants set recovery goals to complete over eight-weeks. The MEMS group also received personalized, interactive text-messages each weekday to support motivation. Retention and engagement in MEMS was high: 92.6% completed 8 weeks of MEMS, with an 86.1% text-message response rate, and 100% reported that they were satisfied with the text-messages. Compared to the control condition, the MEMS group had significantly greater improvements in interviewer-rated motivation and anticipatory pleasure and obtained significantly more recovery-oriented goals at the end of the 8-week period. There were no significant group differences in performance-based effort-cost computations and future reward-value representations, self-reported motivation, quality of life, functioning, or additional secondary outcomes of positive symptoms, mood symptoms, or neurocognition. Results suggest that MEMS is feasible as a relatively brief, low-intensity mobile intervention that could effectively improve interviewer-rated motivation, anticipatory pleasure, and recovery goal attainment in those with schizophrenia-spectrum disorders.
Effects of Aging and Corticofugal Modulation on Startle Behavior and Auditory Physiology
Creators: name: Dowling, Marisa A
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomedical engineering not elsewhere classified

description: Frequency-modulated (FM) sweeps play a key role in species specific communication. Evidence from previous studies have shown that central auditory processing has been shown to vary based on the language spoken, which leads to the idea of experience-driven pitch encoding. Other studies have also shown that there is a decrease in this pitch encoding with aging. Using both iterated rippled noise (IRN) and frequency modulated amplitude modulation (FM/AM) methods to create complex pitch sweeps mimicking speech, allows for the processing of pitch to be determined. Neuromodulation using pharmacogenetics allows for the targeted inhibition of a specific neural pathway. Based on previous studies, the primary auditory cortex to inferior colliculus (A1/IC) pathway is hypothesized to be important in pitch encoding. However, there is a lack of evidence on specifically how the pitch information is encoded in the auditory system and how aging impacts the processing. To solve these issues, age-related changes in pitch encoding and maintaining pitch encoding through neuromodulation were characterized in the using behavioral and electrophysiology methods. Behavioral discrimination abilities, measured by modulation of the acoustic startle response, between pitch sweep direction and pitch sweep creation methods highlighted a reduced discrimination in aging and A1/IC inhibited rats. Electrophysiology changes was assessed using envelope-following responses (EFRs) and suggested a decreased initial frequency locking in aging and decrease in frequency locking overall with A1/IC pathway inhibition. Comparison of behavioral and electrophysiology to IRN and FM/AM stimuli show that the decrease in age-related processing as well as A1/IC pathway processing is larger in the behavioral pitch sweep discrimination than in the reduction in EFRs.
QUASI-TOROIDAL VARIETIES AND RATIONAL LOG STRUCTURES IN CHARACTERISTIC 0
Creators: name: Figuerola, Andres E
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Algebraic and differential geometry

description: We study log varieties, over a field of characteristic zero, which are generically logarithmically smooth and fs in the Kummer normally log étale topology. As an application, we prove an analog of Abramovich-Temkin-Wlodarczyk’s log resolution of singularities of fs log schemes in the Kummer fs setting.
"Local Habitations of A Midsummer Night’s Dream." Shakespeare Bulletin 40.3 (Fall 2022): pp. 417-437.
Creators: name: Joubin, Alexa Alice
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Shakespeare, William, 1564-1616
subject: Film adaptations
subject: Globalization
subject: Theater
subject: COVID-19 (Disease)

description: The metatheatricality of A Midsummer Night’s Dream has invited recent directors to tell particular kinds of socially progressive stories. This article uses the notion of “social reparation” to theorize remedial uses of Shakespeare in adaptations that give artists and audiences more moral agency. By imagining more inclusive local habitations and social spaces for Dream, these socially progressive adaptations seek to remedy injustices in our times and the power asymmetries that inform Shakespeare’s play. My research indicates that place and social space feature prominently in reparative adaptations. To examine the significance of place in performances of Dream, this article analyzes the queer film Were the World Mine (2008), a cross-cultural mime-dance production entitled Dreamer (2016), and the Royal Shakespeare Company’s pandemic-era, interactive, digital performance (2021). All three adaptations draw on the dynamics of their newly created localities to perform various social or artistic mediations.
Additional file 1 of Objective structured clinical examination to teach competency in planetary health care and management – a prospective observational study
Creators: name: Teichgräber, Ulf
name: Ingwersen, Maja
name: Sturm, Max-Johann
name: Giesecke, Jan
name: Allwang, Manuel
name: Herzog, Ida
name: von Gierke, Frederike
name: Schellong, Paul
name: Kolleg, Matthias
name: Lange, Kathleen
name: Wünsch, Daniel
name: Gugel, Katrin
name: Wünsch, Anne
name: Zöllkau, Janine
name: Petruschke, Inga
name: Häseler-Ouart, Kristin
name: Besteher, Bianca
name: Philipp, Swetlana
name: Mille, Urte
name: Ouart, Dominique
name: Jünger, Jana
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1.
Non-stationary Iterative Time-Domain Deconvolution for Enhancing the Resolution of Shallow Seismic Data
Creators: name: Ergun, Erhan
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Geophysics not elsewhere classified

description: The resolution of near-surface seismic reflection data is often limited by attenuation and scattering in the shallow subsurface which reduces the high frequencies in the data. Compensating for attenuation and scattering, as well as removing the propagating source wavelet in a time-variant manner can be used to improve the resolution. Here we investigate continuous non-stationary iterative time-domain deconvolution (CNS-ITD), where the seismic wavelet is allowed to vary along the seismic trace. The propagating seismic wavelet is then a combination of the source wavelet and the effects of attenuation and scattering effects, and can be estimated in a data-driven manner by performing a Gabor decomposition of the data. For each Gabor window, the autocorrelation is estimated and windowed about zero lag to estimate the propagating wavelet. Using the matrix-vector equations, the estimated propagating wavelets are assigned to the related columns of a seismic wavelet matrix, and these are then interpolated to the time location where the maximum of the envelope of the trace occurs within the iterative time-domain deconvolution. Advantages of using this data-driven, time-varying approach include not requiring prior knowledge of the attenuation and scattering structure and allowing for the sparse estimation of the reflectivity within the iterative deconvolution. We first apply CNS-ITD to synthetic data with a time-varying attenuation, where the method successfully identified the reflectors and increased the resolution of the data. We then applied CNS-ITD to two observed shallow seismic reflection datasets where improved resolution was obtained.
Barriers and facilitators to a combined strategy of HPV vaccination and cervical cancer screening among Mexican women
Creators: name: León-Maldonado, Leith
name: Cabral, Alejandra
name: Pages, Gabriela
name: Brown, Brandon
name: Allen-Leigh, Betania
name: Lazcano-Ponce, Eduardo
name: Bosch, Francesc Xavier
name: Spiegelman, Donna
name: Torres-Ibarra, Leticia
name: Hernández-Ramírez, Raúl U.
name: Egger, Emilie
name: Rivera-Paredez, Berenice
name: Salmerón, Jorge
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: HPV-FASTER is an innovative public health intervention combining HPV vaccination and HPV-based screening in adult women at the same visit. FASTER-Tlalpan adapted the combined HPV-FASTER strategy in Tlalpan, Mexico City for women aged 25–45 years. To understand the barriers and facilitators to participation in a combined strategy, we conducted semi-structured interviews with 14 FASTER-Tlalpan participants. We used the constant comparative method for the analysis, as well as the socioecological model to organize the findings. At the intrapersonal level, barriers included the belief that only younger women are at risk for HPV, embarrassment about the pelvic exam, and lack of time, while facilitators were having information regarding the benefit of the combined strategy, perception of time saved by having both procedures at once, feeling reassured about their health, self-esteem regarding their health, and perceived severity of cervical cancer. Interpersonal-level barriers were experiences of stigma and prejudice, and lack of support from partners, while facilitators were family encouragement and peer-to-peer communications. Institutional-level barriers were lack of infrastructure and inconvenient hours at the health center, perceived high time burden, and low quality of care from providers, while facilitators included high-quality care by health center personnel, including partners in the combined strategy, and phone reminders. Community-level facilitators included willingness to participate. Public policy facilitators included mass information campaigns and free procedures. Our findings point to significant barriers which need to be addressed, along with facilitators which can be leveraged to scale up the combined strategy in similar settings.
Approaching Artificial Intelligence in Designing Visual Aids for Teaching Mathematics at High Schools
Creators: name: DUY, Thi Thai Nhat
name: PHU, Du Xuan
name: DUY, Nguyen Hoang
Publisher: name: Zenodo
Year: 2025

description: Today, artificial intelligence has been widely applied in many areas of society, especially in Education. AI tools, increasingly designed to be smarter, have been helpful for many teachers in their instructional tasks. This report presents some research findings on the application of AI tools in designing visual aids for teaching Mathematics at the high school level. Some ideas from the report may suggest trends in applying AI tools to the teaching process in education.
Recommendations of the Standing Committee on Vaccination (STIKO) at the Robert Koch Institute – 2016/2017
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: 610 Medizin

description: These STIKO vaccination recommendations were endorsed during the 82nd and 84th STIKO meetings and are considered enacted upon their publication on 29 August 2016. This 2016 version replaces the previous STIKO vaccination recommendations pub-lished in August 2015 in Epidemiologisches Bulletin (Epid. Bull.) 34/2015 of the Robert Koch Institute (RKI). The scientific rationale for the modified STIKO recommendations will be available in Epid. Bull. 35/2016, 36/2016, and 37/2016 on the RKI website.
Öğretmenlerin Teknolojik Öz Yeterlilikleri
Creators: name: AYAN, Şermin
Publisher: name: Zenodo
Year: 2025

description: Bu araştırmanın amacı, öğretmenlerin teknolojik öz yeterlilik düzeylerini belirlemek ve bu yeterliliklerin eğitim sürecindeki etkilerini incelemektir. Bu çalışmada nicel araştırma yöntemi benimsenmiştir. Araştırmanın evrenini Turtepde yüksek lisans yapan öğretmenler oluşturmakta olup, örneklem grubu 102 katılımcıdan oluşmaktadır. Araştırma 2 aşamadan oluşturulmuştur. Birinci aşamada araştırmacı tarafından katılımcıların cinsiyet, yaş, öğrenim durumu ve mesleki kıdemlerini ölçmek amacıyla araştırmacı tarafından kişisel bilgi formu oluşturulmuştur. İkinci aşamada ise Bayraktar (2015) tarafından geliştirilen öğretmenlerin eğitim teknolojileri kullanım düzeylerini belirleme ölçeği kullanılmıştır. Araştırma sürecinde elde edilen veriler, istatistiksel analiz için SPSS 22 yazılımı kullanılarak incelenmiş ve bu veriler tablolar halinde sunulmuştur. Bulgular, cinsiyetin eğitim teknolojileri kullanım düzeyleri üzerinde anlamlı bir etkisinin olmadığını, kadın ve erkek öğretmenlerin benzer kullanım düzeylerine sahip olduğunu göstermektedir. Yaş grupları arasında ise anlamlı bir fark bulunmuş, genç öğretmenlerin daha yüksek teknoloji kullanım düzeyine sahip olduğu, yaş arttıkça bu düzeyin düştüğü belirlenmiştir. Eğitim durumu açısından yapılan analizlerde ise, ön lisans, lisans ve yüksek lisans mezunları arasında anlamlı bir fark olmadığı tespit edilmiştir. Genel olarak, yaş değişkeninin eğitim teknolojileri kullanımında belirleyici bir faktör olduğu, ancak cinsiyet ve eğitim düzeyinin etkili olmadığı sonucuna ulaşılmıştır. Araştırma, özellikle yaşça büyük öğretmenlere yönelik destekleyici eğitim programlarının gerekliliğini vurgulamakta ve öğretmenlerin demografik özelliklerine göre teknoloji kullanımını artırıcı stratejilerin önemine dikkat çekmektedir.
Attitudes towards vaccination against COVID-19 during pregnancy and its determinants among people of reproductive age
Creators: name: Qin, Chenyuan
name: Ding, Yansheng
name: Liu, Min
name: Liu, Jue
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The attitudes of reproductive-age individuals toward COVID-19 vaccination during pregnancy are still not well understood. We aimed to explore the attitudes toward COVID-19 vaccines during pregnancy and the determinants among the Chinese reproductive-age population. An anonymous cross-sectional study was conducted in China from July 4 to August 11, 2023. Structured questionnaires on vaccine hesitancy during pregnancy, socio-demographic characteristics, behavior characteristics, health-related factors, and mental health status were sent online to reproductive-age individuals (both males and females). Among 2966 participants of reproductive age, 86.9% exhibited significant hesitancy toward receiving the COVID-19 vaccine during pregnancy. Participants of older age (30–34: aOR = 1.71, 95% CI: 1.62–2.52; 35–39: aOR = 1.72, 95% CI: 1.11–2.66), nonsmokers (aOR = 1.42, 95% CI: 1.07–1.89), with a longer duration since their last COVID-19 vaccination (aOR = 2.37, 95% CI: 1.20–4.70), and exhibiting marked pandemic fatigue (moderate: aOR = 1.98, 95% CI: 1.56–2.52; high: aOR = 3.49, 95% CI: 2.41–5.05) were prone to refuse COVID-19 vaccines during pregnancy. The presence of generalized anxiety disorder may push the vaccination (aOR = 0.75, 95% CI: 0.57–0.99). The top three reasons for hesitation were concerns about the adverse health effects of vaccines on pregnant women (77.72%), fetuses (72.13%), and newborns/infants (58.77%), respectively. Therefore, under the context of the existing circumstances and the WHO’s encouragement, this study provides data support for possible future policy changes and emphasizes the importance of public health strategies.
Additional file 7 of Cannulated screws versus dynamic hip screw versus hemiarthroplasty versus total hip arthroplasty in patients with displaced and non-displaced femoral neck fractures: a systematic review and frequentist network meta-analysis of 5703 patients
Creators: name: Ramadanov, Nikolai
name: Jóźwiak, Katarzyna
name: Hauptmann, Michael
name: Lazaru, Philip
name: Marinova-Kichikova, Polina
name: Dimitrov, Dobromir
name: Becker, Roland
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 7: Forest plot of EQ 5D 2 years postoperatively (displaced femoral neck fractures only). CS, cannulated screw; HA, hemiarthroplasty; THA, total hip arthroplasty; SD, standard deviation; MD, mean difference; CI, confidence interval.
Treatment outcome in children with nontuberculous mycobacterial lymphadenitis: A retrospective follow-up study
Creators: name: Reuss, Annicka
name: Drzymala, Sarah
name: Hauer, Barbara
name: Kries, Rüdiger Von
name: Haas, Walter
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: Germany
subject: Antimycobacterial drugs
subject: ethambutol
subject: immunocompromised patients
subject: nontuberculous mycobacterial lymphadenitis
subject: rifamycin
subject: 610 Medizin

description: Introduction: Information on the long-term treatment outcome following nontuberculous mycobacterial (NTM) lymphadenitis is very limited. We performed a study to (a) compare cure rates following different initial treatment courses, (b) describe subsequent treatment courses and their outcomes, and (c) determine the occurrence of late sequelae in immunocompetent children with NTM lymphadenitis. Materials and Methods: In 2011, we conducted a retrospective follow-up study in 71 parents whose children had been hospitalized with NTM disease 2002–2005. A telephone survey was performed using a standardized questionnaire to collect information on the therapeutic management and treatment outcome. Results: Of 61 children with NTM lymphadenitis, 33 (54%) children were cured after the initial treatment. We found no significant difference in cure rates following surgical intervention only (45%, 13/29 children) and a combination of surgical intervention and chemotherapy (61%, 19/31 children). In 7 out of 11 children, the cure rate following complete lymph node excision was 64%. Subsequent courses of treatment including repeated surgical intervention, combination therapy, chemotherapy only, and wait-and-see strategy in children where initial therapy failed resulted in the cure of all 61 children. In four children (7%), recurrences were observed up to 5 years later. Conclusions: Our study showed that recurrent NTM lymphadenitis might be observed several years after initial resolution of disease. The cure rate following complete lymph node excision was lower than reported in other studies. Subsequent treatment courses were necessary in half of the children. Physicians and parents need to be aware that NTM lymphadenitis in children requires careful choice of intervention and active follow-up.
“Writing about War”: Dương Thu Hương’s Representations of the Vietnam-American War
Creators: name: Chattarji, Subarno
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Vietnam War (1961-1975)
subject: Betrayal
subject: Nostalgia
subject: Communism

description: While 30 April 1975 represented the end of hostilities between North and South Vietnam, it was not the end of internecine conflicts. The victorious communists treated Southerners with contempt and subjected them to humiliation and violence, including incarceration in so-called re-education camps. Dương Thu Hương served in the Women’s Youth Brigade during the war and hoped that victory would lead to the establishment of a more egalitarian and democratic society. Dương was appalled when the communist party clamped down on all freedoms and she expressed her dissent in public and through her fiction. This essay analyses two of her novels in English translation, Novel Without a Name (1995) and Memories of a Pure Spring (2000), focusing on recurrent thematics that are central to these works, including the paradoxes of remembrance, critiques of war, the idea of fiction as testimony, and indictments of communist orthodoxy and double standards.
A High-Low Price Anomaly
Creators: name: Johnston, Mitchell S
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Finance

description: I examine movements in the closing price that are different than the movements of the high and low prices on a given day. I construct the measure HLDiff which accumulates the differences between the high-low midpoint return and the closing price return over a month. Instances in which the closing price deviates from the movements in the midpoint between the high and low are a strong predictor of future abnormal returns. The predictive power of the HLDiff measure holds across size groups and sub-periods and holds in the presence of other common determinants of stock returns. The predictive power of HLDiff appears to be driven by the existence of market frictions. Specifically, I find that the premium associated with a factor constructed based on HLDiff is consistent with short-selling constraints inhibiting the correction of overpricing. The factor also appears to improve the pricing ability of the single-factor and five-factor models.
Additional file 1 of Evaluation of the efficacy of a simulation model used in oral and maxillofacial surgery education
Creators: name: Taysi, Aysegul Erten
name: Taysi, Nuri Mert
name: Sismanoglu, Soner
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Theoretical and Numerical Investigation of Nonlinear Thermoacoustic, Acoustic, and Detonation Waves
Creators: name: Gupta, Prateek
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Fluid mechanics and thermal engineering not elsewhere classified
Partial differential equations
Acoustics and acoustical devices; waves

description: Finite amplitude perturbations in compressible media are ubiquitous in scientific and engineering applications such as gas-turbine engines, rocket propulsion systems, combustion instabilities, inhomogeneous solids, and traffic flow prediction models, to name a few. Small amplitude waves in compressible fluids propagate as sound and are very well described by linear theory. On the other hand, the theory of nonlinear acoustics, concerning high-amplitude wave propagation (Mach<2) is relatively underdeveloped. Most of the theoretical development in nonlinear acoustics has focused on wave steepening and has been centered around the Burgers' equation, which can be extended to nonlinear acoustics only for purely one-way traveling waves. In this dissertation, theoretical and computational developments are discussed with the objective of advancing the multi-fidelity modeling of nonlinear acoustics, ranging from quasi one-dimensional high-amplitude waves to combustion-induced detonation waves.

 We begin with the theoretical study of spectral energy cascade due to the propagation of high amplitude sound in the absence of thermal sources. To this end, a first-principles-based system of governing equations, correct up to second order in perturbation variables is derived. The exact energy corollary of such second-order system of equations is then formulated and used to elucidate the spectral energy dynamics of nonlinear acoustic waves. We then extend this analysis to thermoacoustically unstable waves -- i.e. amplified as a result of thermoacoustic instability. We drive such instability up until the generation of shock waves. We further study the nonlinear wave propagation in geometrically complex case of waves induced by the spark plasma between the electrodes. This case adds the geometrical complexity of a curved, three-dimensional shock, yielding vorticity production due to baroclinic torque. Finally, detonation waves are simulated by using a low-order approach, in a periodic setup subjected to high pressure inlet and exhaust of combustible gaseous mixture. An order adaptive fully compressible and unstructured Navier Stokes solver is currently under development to enable higher fidelity studies of both the spark plasma and detonation wave problem in the future.
Closer adult child–parent relations the stronger the vaccine hesitancy: A cross-sectional study of adult Children’s attitudes toward pneumococcal vaccination of elderly parents and its determinants in Guangzhou, China
Creators: name: Wu, Qiqi
name: Zhu, Haiyuan
name: Zhang, Runquan
name: Li, Cuizhi
name: Xiao, Qin
name: Jin, Yuqing
name: Liang, Xiaofeng
name: Chen, Xiongfei
name: Dong, Xiaomei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Pneumococcal disease (PD) has a serious effect on older people aged 60 years and above. However, pneumococcal vaccination rates for older people in China remain low. This study aimed to explore adult children’s perspectives on the vaccination of their parents and to examine the determinants of vaccine hesitancy. In October 2022, a cross-sectional survey was conducted in Guangzhou, China. The questionnaire assesses data on the sociodemographic characteristics of adult children and their parents, health beliefs about vaccination, and variables measuring adult child–parent relationships. Adult child–parent relationships types were identified by Latent Class Analysis (LCA). Binary logistic regression was employed to examine the factors associated with vaccine hesitancy. A total of 1,597 respondents were enrolled in the study, and 59.8% of the adult children expressed hesitancy about vaccinating their elderly parents. The LCA model identified three distinct types of adult child–parent relations: detached, intimate but distant, and tight-knit. Binary logistic regression analyses revealed that respondents with intimate but distant (OR = 3.04) and tight-knit (OR = 3.01) adult child – parent relationships, high literacy (OR = 2.63), and high perceived barriers of vaccine (OR = 1.18) were more likely to be hesitant. Conversely, those with high income (OR = 0.35) and parents with difficulties in activities of daily living (OR = 0.44) were less likely to exhibit vaccine hesitancy. Close adult child–parent relations were positively associated with vaccine hesitancy. Health education related to the vaccination of older persons should be extended to adult children.
INFLATION AND DEPOSIT MOBILIZATION IN DEPOSIT MONEY BANKSTHE NIGERIAN PERSPECTIVE
Creators: name: Essien, Aniekpeno
name: Okoi, Innocent
name: Orok, Akaninyene
Publisher: name: Humanities Commons
Year: 2018
Subjects: subject: Finance
subject: Finance, Public
subject: Inflation (Finance)--Econometric models
subject: Economic development
subject: Banks and banking

description: The broad objective of this study is to critically examine inflation rate in Nigeria with the view of ascertaining its effect on the deposit mobilization in Banks. The study which is ex-post facto, relied mostly on secondary data which were collected through the Central Bank of Nigeria (CBN) statistical bulletin, Nigeria interest research library research, textbooks, journal and report from 1994-2014.The population for this study included selected numbers of banks i.e. deposit money bank in Nigeria from 1994 – 2014. Multiple regression Ordinary Least Square (OLS) statistical tool was applied to establish the like fit to the observed data and the degree of relationship that exist between variables. Findings reveals among others that there exist a significant and negative relationship amongst demand, savings and time deposit with inflation in Nigeria, and that interest rate impacted significantly and positively on saving and time deposit .It is recommended among others evaluation of the marginal increment of deposit interest rate for savings and time Deposit through Central Bank of Nigeria Monetary Policy Committee (MPC) at higher rate than inflation as an incentive to attract high deposit mobilization, and encouragement of increased trade activities geared towards increased money supply in the economy.
Changes to cholesterol trafficking in macrophages by Leishmania parasites infection
Creators: name: Semini, Geo
name: Paape, Daniel
name: Paterou, Athina
name: Schroeder, Juliane
name: Barrios-Llerena, Martin
name: Aebischer, Toni
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases. It has been demonstrated that host cholesterol plays an important role during Leishmania infection. Nevertheless, little is known about the intracellular distribution of this lipid early after internalization of the parasite. Here, pulse-chase experiments with radiolabeled cholesteryl esterified to fatty acids bound to low-density lipoproteins indicated that retention of this source of cholesterol is increased in parasite-containing subcellular fractions, while uptake is unaffected. This is correlated with a reduction or absence of detectable NPC1 (Niemann–Pick disease, type C1), a protein responsible for cholesterol efflux from endocytic compartments, in the Leishmania mexicana habitat and infected cells. Filipin staining revealed a halo around parasites within parasitophorous vacuoles (PV) likely representing free cholesterol accumulation. Labeling of host cell membranous cholesterol by fluorescent cholesterol species before infection revealed that this pool is also trafficked to the PV but becomes incorporated into the parasites’ membranes and seems not to contribute to the halo detected by filipin. This cholesterol sequestration happened early after infection and was functionally significant as it correlated with the upregulation of mRNA-encoding proteins required for cholesterol biosynthesis. Thus, sequestration of cholesterol by Leishmania amastigotes early after infection provides a basis to understand perturbation of cholesterol-dependent processes in macrophages that were shown previously by others to be necessary for their proper function in innate and adaptive immune responses.
Knowledge, attitudes, and beliefs of pharmacists regarding vaccinations against influenza and pneumococci – a systematic review
Creators: name: Waszkiewicz, Michał
name: Wnuk, Katarzyna
name: Świtalski, Jakub
name: Augustynowicz, Anna
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Pharmacists’ knowledge, attitudes, and beliefs regarding vaccination can significantly influence patients’ willingness to receive vaccinations. This study aims to assess the level of knowledge, attitudes, and beliefs of pharmacists toward influenza and pneumococcal vaccinations. On February 17, 2024, a systematic search was conducted in the Medline (via PubMed), Embase (via Ovid), and The Cochrane Library databases, following PRISMA guidelines. Before analyzing the results, the study protocol was registered in the PROSPERO database (CRD42024566984). Of the 1,209 studies identified, 24 publications met the inclusion criteria for analysis. Most of these (n = 22) were cross-sectional studies using proprietary questionnaires. The studies found that pharmacists possess unsatisfactory knowledge about influenza and pneumococcal vaccinations. Shortcomings in attitudes and beliefs about vaccination safety were also evident, along with a deficiencies of promotion of vaccinations to patients.
Additional file 15 of Cannulated screws versus dynamic hip screw versus hemiarthroplasty versus total hip arthroplasty in patients with displaced and non-displaced femoral neck fractures: a systematic review and frequentist network meta-analysis of 5703 patients
Creators: name: Ramadanov, Nikolai
name: Jóźwiak, Katarzyna
name: Hauptmann, Michael
name: Lazaru, Philip
name: Marinova-Kichikova, Polina
name: Dimitrov, Dobromir
name: Becker, Roland
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 15: Forest plot of infection (displaced femoral neck fractures only). CS, cannulated screw; DHS, dynamic hip screw; HA, hemiarthroplasty; THA, total hip arthroplasty; OR, odds ratio; CI, confidence interval.
Analysis Techniques for Characterizing High Power Turbulent Swirl Flames
Creators: name: Zhang, Robert Z
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Chemical and thermal processes in energy and combustion
Turbulent flows
Aerospace engineering not elsewhere classified

description: High speed laser diagnostics are performed in two vastly differing swirl combustors at conditions relevant for industrial gas turbines. This high quality data can not only be used to elucidate key features of the flow field but also for validation of computational models simulating turbulence, chemistry, and their interactions. The first combustor is a piloted lean premixed prevaporized arrangement common in aviation applications. Fueling parameters are varied and sensitivity towards the pilot flame is observed. Conditioning to the stagnation line demonstrates increased fluctuations of shear and rotation in the inner shear layer when the pilot fueling is reduced.
The second flame has a simpler configuration with a single swirler and combusting natural gas. Thermoacoustic instability coupled to a helical precessing vortex core is found at certain conditions. Sparse Dynamic Mode Decomposition and phase averaging is applied to the velocity fields to create a three dimensional reconstruction of the helical vortex core in a non-precessing reference frame. Heat release is found to be correlated to the interaction strength of the central recirculation bubble and the helical vortex core.
 Finally, intermittent phenomena within a thermoacoustic instability are examined. The most prominent deviation is that the flame is observed to randomly lift and reattach. In addition, a convolutional neural network is employed to extract the morphology from otherwise qualitative OH species imaging. The average characteristics of the lifted and attached flame are compared and dramatic differences are found. All of the flow structures have been altered such as the precessing vortex core being greatly intensified during flame lift-off. Evaluating the average events before flame lift-off revealed the importance of conditions at the combustor inlet. However, evidence for a future reattachment event was only found with a less spatially confined perspective. In addition, transition to lift-off was very sudden while reattachment was far slower.
Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013–2016
Creators: name: Garske, Tini
name: Cori, Anne
name: Ariyarajah, Archchun
name: Blake, Isobel M.
name: Dorigatti, Ilaria
name: Eckmanns, Tim
name: Fraser, Christophe
name: Hinsley, Wes
name: Jombart, Thibaut
name: Mills, Harriet L.
name: Nedjati-Gilani, Gemma
name: Newton, Emily
name: Nouvellet, Pierre
name: Perkins, Devin
name: Riley, Steven
name: Schumacher, Dirk
name: Shah, Anita
name: Kerkhove, Maria D. Van
name: Dye, Christopher
name: Ferguson, Neil M.
name: Donnelly, Christl A.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: 610 Medizin

description: The 2013–2016 Ebola outbreak in West Africa is the largest on record with 28 616 confirmed, probable and suspected cases and 11 310 deaths officially recorded by 10 June 2016, the true burden probably considerably higher. The case fatality ratio (CFR: proportion of cases that are fatal) is a key indicator of disease severity useful for gauging the appropriate public health response and for evaluating treatment benefits, if estimated accurately. We analysed individual-level clinical outcome data from Guinea, Liberia and Sierra Leone officially reported to the World Health Organization. The overall mean CFR was 62.9% (95% CI: 61.9% to 64.0%) among confirmed cases with recorded clinical outcomes. Age was the most important modifier of survival probabilities, but country, stage of the epidemic and whether patients were hospitalized also played roles. We developed a statistical analysis to detect outliers in CFR between districts of residence and treatment centres (TCs), adjusting for known factors influencing survival and identified eight districts and three TCs with a CFR significantly different from the average. From the current dataset, we cannot determine whether the observed variation in CFR seen by district or treatment centre reflects real differences in survival, related to the quality of care or other factors or was caused by differences in reporting practices or case ascertainment. This article is part of the themed issue ‘The 2013–2016 West African Ebola epidemic: data, decision-making and disease control’.
Additional file 1 of Association between joint physical activity and healthy dietary patterns and hypertension in US adults: cross-sectional NHANES study
Creators: name: Zhu, Yanzhou
name: Wang, Zhigang
Publisher: name: figshare
Year: 2024
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Supplementary Material 1.