cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Urbanes Monitoring erdfallinduzierter Deformationen: Grenzen und Chancen bei der Kombination von NSS, Nivellement und Gravimetrie
Creators: name: Kersten, Tobias
name: Weise, Adelheid
name: Timmen, Ludger
name: Gabriel, Gerald
name: Schön, Steffen
name: Vogel, Detlef
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2019
Subjects: subject: GNSS
subject: Geomonitoring
subject: Erdfall
subject: zeitliche Veränderungen
subject: Massentransfer
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau::624 | Ingenieurbau und Umwelttechnik

description: Senkungsvorgänge der Erdoberfläche stellen vor allem in urbanen Gebieten eine deutliche Gefährdung dar. Oftmals sind diese Senkungen durch Massenvariationen im Untergrund verursacht und führen zu langsamen, aber auch abrupten Einsenkungen der Erdoberfläche. Im Rahmen des Verbundprojektes SIMULTAN (Sinkhole Instability: MULti-scale monitoring and ANalysis) wird die Untersuchung dieser Phänomene auf Grundlage geophysikalisch-geodätischer Methoden durchgeführt, um ein tieferes Verständnis der komplexen Zusammenhänge zwischen Auslaugungsprozessen im Untergrund und den eintretenden Effekten auf der Erdoberfläche zu gewinnen. In dem hierzu angelegtem integrierten geodätisch-gravimetrischen Überwachungsnetz werden die Methoden Gravimetrie, Nivellement und GNSS zusammengeführt und die Ergebnisse der zeitlichen Variationen bzw. auftretenden Deformationen in einem urbanen Umfeld auf Signifikanz hin untersucht. Basierend auf den GNSS-Kampagnen, die in den Jahren 2015-2017 in Hamburg Groß Flottbek durchgeführt wurden, lassen sich Erkenntnisse gewinnen, auf welcher Ebene und in welchem Umfang die einzelnen Methoden und deren Kombination erfolgreich eingesetzt werden können. Es wird aufgezeigt, dass die Kombination zu sehr guten Übereinstimmungen führt und Senkungen von 1,5-2 mm durch alle Methoden nachweisbar sind, obwohl die innerstädtische Kubatur eine komplexe Vielzahl an Herausforderungen an eine präzise GNSS-Auswertung aufweist.
Automatic Verification of Erlang-Style Concurrency
Creators: name: D'Osualdo, Emanuele
name: Kochems, Jonathan
name: Ong, C. -H. Luke
Publisher: name: arXiv
Year: 2013
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D.2.4

description: This paper presents an approach to verify safety properties of Erlang-style, higher-order concurrent programs automatically. Inspired by Core Erlang, we introduce Lambda-Actor, a prototypical functional language with pattern-matching algebraic data types, augmented with process creation and asynchronous message-passing primitives. We formalise an abstract model of Lambda-Actor programs called Actor Communicating System (ACS) which has a natural interpretation as a vector addition system, for which some verification problems are decidable. We give a parametric abstract interpretation framework for Lambda-Actor and use it to build a polytime computable, flow-based, abstract semantics of Lambda-Actor programs, which we then use to bootstrap the ACS construction, thus deriving a more accurate abstract model of the input program. We have constructed Soter, a tool implementation of the verification method, thereby obtaining the first fully-automatic, infinite-state model checker for a core fragment of Erlang. We find that in practice our abstraction technique is accurate enough to verify an interesting range of safety properties. Though the ACS coverability problem is Expspace-complete, Soter can analyse these verification problems surprisingly efficiently.
description: 12 pages plus appendix, 4 figures, 1 table. The tool is available at http://mjolnir.cs.ox.ac.uk/soter/
A Checklist to Publish Collections as Data in GLAM Institutions
Creators: name: Candela, Gustavo
name: Gabriëls, Nele
name: Chambers, Sally
name: Pham, Thuy-An
name: Ames, Sarah
name: Fitzgerald, Neil
name: Hofmann, Katrine
name: Harbo, Victor
name: Potter, Abigail
name: Ferriter, Meghan
name: Manchester, Eileen
name: Irollo, Alba
name: Van Keer, Ellen
name: Mahey, Mahendra
name: Holownia, Olga
name: Dobreva, Milena
Publisher: name: arXiv
Year: 2023
Subjects: subject: Digital Libraries (cs.DL)
subject: FOS: Computer and information sciences

description: Large-scale digitization in Galleries, Libraries, Archives and Museums (GLAM) created the conditions for providing access to collections as data. It opened new opportunities to explore, use and reuse digital collections. Strong proponents of collections as data are the Innovation Labs which provided numerous examples of publishing datasets under open licenses in order to reuse digital content in novel and creative ways. Within the current transition to the emerging data spaces, clouds for cultural heritage and open science, the need to identify practices which support more GLAM institutions to offer datasets becomes a priority, especially within the smaller and medium-sized institutions. This paper answers the need to support GLAM institutions in facilitating the transition into publishing their digital content and to introduce collections as data services; this will also help their future efficient contribution to data spaces and cultural heritage clouds. It offers a checklist that can be used for both creating and evaluating digital collections suitable for computational use. The main contributions of this paper are i) a methodology for devising a checklist to create and assess digital collections for computational use; ii) a checklist to create and assess digital collections suitable for use with computational methods; iii) the assessment of the checklist against the practice of institutions innovating in the Collections as data field; and iv) the results obtained after the application and recommendations for the use of the checklist in GLAM institutions.
description: This is an original manuscript of an article published by Emerald Publishing Limited in Global Knowledge, Memory and Communication on 9 November 2023, available online: https://doi.org/10.1108/GKMC-06-2023-0195
Holographic Codes from Hyperinvariant Tensor Networks
Creators: name: Steinberg, Matthew
name: Feld, Sebastian
name: Jahn, Alexander
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Holographic quantum-error correcting codes are models of bulk/boundary dualities such as the anti-de Sitter/conformal field theory (AdS/CFT) correspondence, where a higher-dimensional bulk geometry is associated with the code's logical degrees of freedom. Previous discrete holographic codes based on tensor networks have reproduced the general code properties expected from continuum AdS/CFT, such as complementary recovery. However, the boundary states of such tensor networks typically do not exhibit the expected correlation functions of CFT boundary states. In this work, we show that a new class of exact holographic codes, extending the previously proposed hyperinvariant tensor networks into quantum codes, produce the correct boundary correlation functions. This approach yields a dictionary between logical states in the bulk and the critical renormalization group flow of boundary states. Furthermore, these codes exhibit a state-dependent breakdown of complementary recovery as expected from AdS/CFT under small quantum gravity corrections.
description: 10 pages, 7 figures
Orchis maculata X Traunsteineri
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: O.maculata X Traunsteineri - 4:Eine anscheinend hierher zu stellende Pflanze östlich Imfeld im Binn- tal, etwa 1700m (Gsell 1938).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
A Study on Fuzzy Systems
Creators: name: Voskoglou, Michael Gr.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: 03E72

description: We use princiles of fuzzy logic to develop a general model representing several processes in a system's operation characterized by a degree of vagueness and/or uncertainy. Further, we introduce three altenative measures of a fuzzy system's effectiveness connected to the above model. An applcation is also developed for the Mathematical Modelling process illustrating our results.
description: 9 pages, 3 figures, 1 table
Untersuchung des Translokationsmechanismus clostridieller Neurotoxine und ihrer potentiellen Nutzung als Proteintransporter
Creators: name: Bade, Steffen
Publisher: name: Hannover : Universität
Year: 2002
Subjects: subject: Clostridial neurotoxins
subject: translocation
subject: protein transporter
subject: fusion proteins
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: [no abstract]
Thermodynamics and Spectroscopy of Schwarzschild black hole surrounded by Quintessence
Creators: name: Tharanath, R
name: Kuriakose, V C
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The thermodynamic and spectroscopic behaviour of Schwarzschild black hole surrounded by quintessence are studied. We have derived the thermodynamic quantities and studied their behaviour for different values of quintessence parameter. We put the background space-time into the Kruskal-like coordinate to find the period with respect to Elucidean time. Also assuming that the adiabatic invariant obeys Bohr-Sommerfeld quantization rule, detailed study of area spectrum and entropy spectrum have been done for special cases of the quintessece state parameter. We find that the spectra are equally spaced.
description: 11 pages and 4 figures
The girth, odd girth, distance function, and diameter of generalized Johnson graphs
Creators: name: Caughman, John S.
name: Herman, Ari J.
name: Terada, Taiyo S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: For any non-negative integers $v > k > i$, the {\em generalized Johnson graph}, $J(v,k,i)$, is the undirected simple graph whose vertices are the $k$-subsets of a $v$-set, and where any two vertices $A$ and $B$ are adjacent whenever $|A \cap B| =i$. In this article, we derive formulas for the girth, odd girth, distance function, and diameter of $J(v,k,i)$.
A primal--dual algorithm as applied to optimal control problems
Creators: name: Burachik, Regina S.
name: Kaya, C. Yalçın
name: Liu, Xuemei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 49M29, 49M30, 90C26, 90C90

description: We propose a primal--dual technique that applies to infinite dimensional equality constrained problems, in particular those arising from optimal control. As an application of our general framework, we solve a control-constrained double integrator optimal control problem and the challenging control-constrained free flying robot optimal control problem by means of our primal--dual scheme. The algorithm we use is an epsilon-subgradient method that can also be interpreted as a penalty function method. We provide extensive comparisons of our approach with a traditional numerical approach.
Simultaneous structuring and scheduling of multiple projects with flexible project structures
Creators: name: Hoffmann, Luise-Sophie
name: Kellenbrink, Carolin
name: Helber, Stefan
Publisher: name: Berlin : Springer
Year: 2020
Subjects: subject: Flexible projects
subject: Genetic algorithms
subject: Multi-project scheduling
subject: RCMPSP
subject: RCPSP
subject: Dewey Decimal Classification::600 | Technik::650 | Management

description: We study the problem to simultaneously decide on the structures and the schedules for an entire portfolio of flexible projects. The projects are flexible as alternative technologies and procedures can be used to achieve the respective project task. The choice between different technologies and procedures affects the activities to be implemented and thus the precedence relations, i.e., the structure of the project. The different projects have given due dates with specific delay payments and compete for scarce resources. In this situation, project structure decisions and scheduling decisions are highly intertwined and have to be made simultaneously in order to achieve the assumed objective of minimizing the delay payments for the entire project portfolio. The problem is formally stated and solved via novel and problem-specific genetic algorithms. The performance of the new algorithms is evaluated with respect to speed and accuracy in a systematic and comprehensive numerical study. © 2020, The Author(s).
Supplementary Material from Complex relationships between climate and reproduction in a resident montane bird
Creators: name: Whitenack, Lauren E.
name: Welklin, Joseph F.
name: Branch, Carrie L.
name: Sonnenberg, Benjamin R.
name: Pitera, Angela M.
name: Kozlovsky, Dovid Y.
name: Benedict, Lauren M.
name: Heinen, Virginia K.
name: Pravosudov, Vladimir V.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Animals use climate-related environmental cues to fine-tune breeding timing and investment to match peak food availability. In birds, spring temperature is a commonly documented cue used to initiate breeding, but with global climate change, organisms are experiencing both directional changes in ambient temperatures and extreme year-to-year precipitation fluctuations. Montane environments exhibit complex climate patterns where temperatures and precipitation change along elevational gradients, and where exacerbated annual variation in precipitation has resulted in extreme swings between heavy snow and drought. We used 10 years of data to investigate how annual variation in climatic conditions is associated with differences in breeding phenology and reproductive performance in resident mountain chickadees (Poecile gambeli) at two elevations in the northern Sierra Nevada mountains, USA. Variation in spring temperature was not associated with differences in breeding phenology across elevations in our system. Greater snow accumulation was associated with later breeding initiation at high, but not low, elevation. Brood size was reduced under drought, but only at low elevation. Our data suggest complex relationships between climate and avian reproduction and point to autumn climate as important for reproductive performance, likely via its effect on phenology and abundance of invertebrates.
Nachweis von subrosionsinduziertem Massentransfer in urbanen Gebieten mittels gravimetrischem Monitoring
Creators: name: Kobe, Martin
name: Weise, Adelheid
name: Gabriel, Gerald
name: Timmen, Ludger
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2019
Subjects: subject: Subrosion
subject: Erdfälle
subject: gravimetrisches Monitoring
subject: Bodenwasserkorrektur
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau::624 | Ingenieurbau und Umwelttechnik

description: Subrosion, d.h. die Auslaugung und Verlagerung leicht lösbarer Gesteine im Untergrund, ist ein weltweites Phänomen. Sie führt zu lokalen Massenverlusten und damit zur Entwicklung von Erdfällen in Form von Subrosionssenken bis hin zu Kollapsereignissen, was im urbanen Raum ein erhebliches Risiko für Infrastruktur und Menschenleben darstellt. Dieser Beitrag beschäftigt sich mit der geodätisch-gravimetrischen Überwachung zweier Erdfallgebiete in Bad Frankenhausen und Hamburg-Flottbek. In lokalen Monitoringnetzen wurden über einen Zeitraum von mehreren Jahren regelmäßig wiederholte Schwere- und Höhenmessungen durchgeführt, um die Massenverlagerungen im Untergrund und damit verbundene Subsidenz zu erfassen. In beiden Messgebieten wurden Absenkungen um Millimeter bis wenige Zentimeter über den Untersuchungszeitraum erfasst. Außerdem wurden lokal signifikante, zeitliche Schwereänderungen von 1-2 µGal/a beobachtet. Als wichtig erwiesen sich hierbei sowohl die Korrektur des Einflusses zeitlicher Variationen im Bodenwassergehalt auf die Schweremessungen, wie auch die Kombination von Relativ- und Absolutgravimetrie zur Stabilitätskontrolle der großräumigen Schwerereferenz. Wenngleich die beobachteten Schwereänderungen klein sind und sich aus der Konfiguration der Messnetze, den urbanen Umgebungsbedingungen und der Mehrdeutigkeit der Gravimetrie Limitationen ergeben, ist die Durchführbarkeit von gravimetrischen Wiederholungsmessungen in Subrosionsgebieten sinnvoll und erfolgreich.
Orchis mascula
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: O. mascula X pallens - l: Ob Messe (Wilczek, Garns). - 2: Ob Branson (F, Garns); Jeur-Brûlée (Garns).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Mutagenesis of the l-Amino Acid Ligase RizA Increased the Production of Bioactive Dipeptides
Creators: name: Bordewick, Sven
name: Berger, Ralf G.
name: Ersoy, Franziska
Publisher: name: Basel : MDPI
Year: 2021
Subjects: subject: l-amino acid ligase
subject: biocatalysis
subject: mutagenesis
subject: coupled catalysis
subject: arginyl dipeptides
subject: salt taste
subject: protein engineering
subject: substrate specificity
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: The l-amino acid ligase RizA from B. subtilis selectively synthesizes dipeptides containing an N-terminal arginine. Many arginyl dipeptides have salt-taste enhancing properties while Arg-Phe has been found to have an antihypertensive effect. A total of 21 RizA variants were created by site-directed mutagenesis of eight amino acids in the substrate binding pocket. The variants were recombinantly produced in E. coli and purified by affinity chromatography. Biocatalytic reactions were set up with arginine and four amino acids differing in size and polarity (aspartic acid, serine, alanine, and phenylalanine) and were analyzed by RP-HPLC with fluorescence detection. Variant T81F significantly improved the yield in comparison to wild type RizA for aspartic acid (7 to 17%), serine (33 to 47%) and alanine (12 to 17%). S84F increased product yield similarly for aspartic acid (7 to 17%) and serine (33 to 42%). D376E increased the yield with alanine (12 to 19%) and phenylalanine (11 to 26%). The largest change was observed for S156A, which showed a yield for Arg-Phe of 40% corresponding to a 270% increase in product concentration. This study expands the knowledge about positions governing the substrate specificity of RizA and may help to inform future protein engineering endeavors.
Should ChatGPT be Biased? Challenges and Risks of Bias in Large Language Models
Creators: name: Ferrara, Emilio
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computers and Society (cs.CY)
subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: As the capabilities of generative language models continue to advance, the implications of biases ingrained within these models have garnered increasing attention from researchers, practitioners, and the broader public. This article investigates the challenges and risks associated with biases in large-scale language models like ChatGPT. We discuss the origins of biases, stemming from, among others, the nature of training data, model specifications, algorithmic constraints, product design, and policy decisions. We explore the ethical concerns arising from the unintended consequences of biased model outputs. We further analyze the potential opportunities to mitigate biases, the inevitability of some biases, and the implications of deploying these models in various applications, such as virtual assistants, content generation, and chatbots. Finally, we review the current approaches to identify, quantify, and mitigate biases in language models, emphasizing the need for a multi-disciplinary, collaborative effort to develop more equitable, transparent, and responsible AI systems. This article aims to stimulate a thoughtful dialogue within the artificial intelligence community, encouraging researchers and developers to reflect on the role of biases in generative language models and the ongoing pursuit of ethical AI.
description: Published on First Monday https://firstmonday.org/ojs/index.php/fm/article/view/13346/11365
Languages cool as they expand: Allometric scaling and the decreasing need for new words
Creators: name: Petersen, Alexander M.
name: Tenenbaum, Joel N.
name: Havlin, Shlomo
name: Stanley, H. Eugene
name: Perc, Matjaz
Publisher: name: arXiv
Year: 2012
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computation and Language (cs.CL)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We analyze the occurrence frequencies of over 15 million words recorded in millions of books published during the past two centuries in seven different languages. For all languages and chronological subsets of the data we confirm that two scaling regimes characterize the word frequency distributions, with only the more common words obeying the classic Zipf law. Using corpora of unprecedented size, we test the allometric scaling relation between the corpus size and the vocabulary size of growing languages to demonstrate a decreasing marginal need for new words, a feature that is likely related to the underlying correlations between words. We calculate the annual growth fluctuations of word use which has a decreasing trend as the corpus size increases, indicating a slowdown in linguistic evolution following language expansion. This "cooling pattern" forms the basis of a third statistical regularity, which unlike the Zipf and the Heaps law, is dynamical in nature.
description: 9 two-column pages, 7 figures; accepted for publication in Scientific Reports
Sulfitoxidase aus dem marinen Bakterium Sulfitobacter pontiacus : Untersuchungen zur Optimierung der Kultivierungsbedingungen und zur Aufreinigung des Enzyms
Creators: name: Arndt, Matthias
Publisher: name: Hannover : Universität
Year: 2002
Subjects: subject: Sulfitobacter pontiacus
subject: sulfite oxidase
subject: cultivation conditions
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::370 | Erziehung, Schul- und Bildungswesen
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::340 | Recht

description: [no abstract]
Information Transfer in the Agricultural Sector in Spain
Creators: name: Munoz-Canavate, Antonio
name: Hipola, Pedro
Publisher: name: arXiv
Year: 2013
Subjects: subject: Digital Libraries (cs.DL)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: This article examines the structures of information transfer to the agricultural (production) and agro-alimentary (transformation and commercialization of the products) sector within Spain. An historical perspective is provided to better illustrate the reality and complexity of Spain with regard to the systems of agrarian extension, agricultural research, the resources provided by Spain's central administration, and the use of information by related enterprises. The Service of Agrarian Extension appeared in Spain in the 1950s, and new political-administrative structures (agribusiness associations, cooperatives) were founded when Spain became a democratic nation in the late 1970s and with the arrival of electronic information, largely in the 1990s. We describe the research and technological centers supporting innovation in the agro-alimentary sector and the communication media dedicated to the agricultural sector. The article illustrates that the systems of agricultural information in Spain have been largely derived from initiatives of the Public Administration, with few private initiatives.
Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention
Creators: name: Alnajjar, Suhayla
name: Nolte, Ingo
name: Becker, Annegret
name: Schille, Jan Torben
name: Trakooljul, Nares
name: Frank, Marcus
name: Ngezahayo, Anaclet
name: Murua Escobar, Hugo
Publisher: name: Basel : Molecular Diversity Preservation International (MDPI)
Year: 2021
Subjects: subject: cell lines
subject: prostate cancer
subject: C-CPE
subject: gold nanoparticle
subject: GNOME-LP
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Claudin (CLDN) proteins are commonly expressed in cancers and targeted in novel therapeutic approaches. The C-terminal of Clostridium perfringens enterotoxin (C-CPE) efficiently binds several claudins. In this study, recombinant C-CPE conjugated to gold nanoparticles (AuNPs) has been used for prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) cell killing in vitro using gold-nanoparticle-mediated laser perforation (GNOME-LP). A PAC and TCC cell lines, as well as red fluorescence variants, allowing deep tissue imaging, were used. CLDN-3, -4, and -7 expression was confirmed by qPCR and immunofluorescences. The binding of C-CPE-AuNPs complexes on the cell surface was examined by scanning electron microscopy (SEM). Further, transcriptome analysis was carried out to evaluate the effect of C-CPE binder on the biological response of treated cells. Directed C-CPE-AuNP binding verified the capability to target CLDN receptors. Transcriptome analysis showed that C-CPE binding may activate immune and inflammatory responses but does not directly affect cell survival. Cancer cells ablation was demonstrated using a combination of GNOME-LP and C-CPE-AuNPs treatment reducing tumor cell viability to less than 10% depending on cell line. The fluorescent cell lines and the verified proof of concept in vitro provide the basis for perspective xenograft studies in an animal model.
Are the ultra-high-redshift galaxies at z > 10 surprising in the context of standard galaxy formation models?
Creators: name: Yung, L. Y. Aaron
name: Somerville, Rachel S.
name: Finkelstein, Steven L.
name: Wilkins, Stephen M.
name: Gardner, Jonathan P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A substantial number of ultra-high redshift (8 < z < 17) galaxy candidates have been detected with JWST, posing the question: are these observational results surprising in the context of current galaxy formation models? We address this question using the well-established Santa Cruz semi-analytic models, implemented within merger trees from the new suite of cosmological N-body simulations GUREFT, which were carefully designed for ultra-high redshift studies. Using our fiducial models calibrated at z=0, we present predictions for stellar mass functions, rest-frame UV luminosity functions, and various scaling relations. We find that our (dust-free) models predict galaxy number densities at z~11 (z~13) that are an order of magnitude (a factor of ~30) lower than the observational estimates. We estimate the uncertainty in the observed number densities due to cosmic variance, and find that it leads to a fractional error of ~20-30% at z=11 (~30-80% at z=14) for a 100 sq arcmin field. We explore which processes in our models are most likely to be rate-limiting for the formation of luminous galaxies at these early epochs, considering the halo formation rate, gas cooling, star formation, and stellar feedback, and conclude that it is mainly efficient stellar-driven winds. We find that a modest boost of a factor of ~4 to the UV luminosities, which could arise from a top-heavy stellar initial mass function, would bring our current models into agreement with the observations. Adding a stochastic component to the UV luminosity can also reconcile our results with the observations.
description: 20 pages, 16 figures, accepted for publication in MNRAS
Dignifying Life Beyond the Streets
Creators: name: Chocontá, Laura
Publisher: name: Hannover : Leibniz Universität Hannover, Institut für Umweltplanung
Year: 2019
Subjects: subject: Economic crisis
subject: Resilience
subject: Urbanism
subject: Dewey Decimal Classification::700 | Künste, Bildende Kunst allgemein::710 | Landschaftsgestaltung, Raumplanung

description: Home, and therefore homelessness, can have different meanings according to one‘s background but it mandates a sensitive response. An adequate approach to it should be insightful of its implications, and so, a common understanding of the term was formulated. Through brainstorming (see Fig. 1) the team in charge of the topic defined homelessness as the lack of physical shelter and social relations that support the dignity of life. At the same time, the relation with dignity of life included: a good quality of physical shelter (by keeping up with hygiene standards, providing adequate protection from environment, and having access to all essential services); the possibility to access health facilities; the existence of economic opportunities; and access to and positive participation in a social network (for a feeling of belonging and good relations with others). It was also noticed that a homelessness situation could happen during different periods and because of many reasons, but it becomes especially concerning when such case strikes suddenly and persists for long. In Athens, after the lengthened economic crisis of 2013, about 9,100 people experienced some form of visible homelessness in the wider metropolitan area (ANDRIOPOULOU et al. 2017: p. 2). Despite the significant deterioration in the problem, no changes in the policy have been made - the current range of policies working in the issue focus on the management of its most extreme and publicly visible manifestations (KOURACHANIS 2015: p. 123), leaving a need for new responses to the issue. New strategies should have a more conscious approach of the matter and, furthermore, they need to be a milestone in building social resilience so that future crisis can be overcome faster.
High-Fidelity, Frequency-Flexible Two-Qubit Fluxonium Gates with a Transmon Coupler
Creators: name: Ding, Leon
name: Hays, Max
name: Sung, Youngkyu
name: Kannan, Bharath
name: An, Junyoung
name: Di Paolo, Agustin
name: Karamlou, Amir H.
name: Hazard, Thomas M.
name: Azar, Kate
name: Kim, David K.
name: Niedzielski, Bethany M.
name: Melville, Alexander
name: Schwartz, Mollie E.
name: Yoder, Jonilyn L.
name: Orlando, Terry P.
name: Gustavsson, Simon
name: Grover, Jeffrey A.
name: Serniak, Kyle
name: Oliver, William D.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose and demonstrate an architecture for fluxonium-fluxonium two-qubit gates mediated by transmon couplers (FTF, for fluxonium-transmon-fluxonium). Relative to architectures that exclusively rely on a direct coupling between fluxonium qubits, FTF enables stronger couplings for gates using non-computational states while simultaneously suppressing the static controlled-phase entangling rate ($ZZ$) down to kHz levels, all without requiring strict parameter matching. Here we implement FTF with a flux-tunable transmon coupler and demonstrate a microwave-activated controlled-Z (CZ) gate whose operation frequency can be tuned over a 2 GHz range, adding frequency allocation freedom for FTF's in larger systems. Across this range, state-of-the-art CZ gate fidelities were observed over many bias points and reproduced across the two devices characterized in this work. After optimizing both the operation frequency and the gate duration, we achieved peak CZ fidelities in the 99.85-99.9\% range. Finally, we implemented model-free reinforcement learning of the pulse parameters to boost the mean gate fidelity up to $99.922\pm0.009\%$, averaged over roughly an hour between scheduled training runs. Beyond the microwave-activated CZ gate we present here, FTF can be applied to a variety of other fluxonium gate schemes to improve gate fidelities and passively reduce unwanted $ZZ$ interactions.
description: 23 pages, 16 figures
Optically trapped Feshbach molecules of fermionic 161Dy and 40K
Creators: name: Soave, E.
name: Canali, A.
name: Ye, Zhu-Xiong
name: Kreyer, M.
name: Kirilov, E.
name: Grimm, R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report on the preparation of a pure ultracold sample of bosonic DyK Feshbach molecules, which are composed of the fermionic isotopes 161Dy and 40K. Employing a magnetic sweep across a resonance located near 7.3 G, we produce up to 5000 molecules at a temperature of about 50 nK. For purification from the remaining atoms, we apply a Stern-Gerlach technique based on magnetic levitation of the molecules in a very weak optical dipole trap. With the trapped molecules we finally reach a high phase-space density of about 0.1. We measure the magnetic field dependence of the molecular binding energy and the magnetic moment, refining our knowledge of the resonance parameters. We also demonstrate a peculiar anisotropic expansion effect observed when the molecules are released from the trap and expand freely in the magnetic levitation field. Moreover, we identify an important lifetime limitation that is imposed by the 1064-nm infrared trap light itself and not by inelastic collisions. The light-induced decay rate is found to be proportional to the trap light intensity and the closed-channel fraction of the Feshbach molecule. These observations suggest a one-photon coupling to electronically excited states to limit the lifetime and point to the prospect of loss suppression by optimizing the wavelength of the trapping light. Our results represent important insights and experimental steps on the way to achieve quantum-degenerate samples of DyK molecules and novel superfluids based on mass-imbalanced fermion mixtures.
Experimental Performance of a Quantum Simulator: Optimizing Adiabatic Evolution and Identifying Many-Body Ground States
Creators: name: Richerme, Philip
name: Senko, Crystal
name: Smith, Jacob
name: Lee, Aaron
name: Korenblit, Simcha
name: Monroe, Christopher
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We use local adiabatic evolution to experimentally create and determine the ground state spin ordering of a fully-connected Ising model with up to 14 spins. Local adiabatic evolution -- in which the system evolution rate is a function of the instantaneous energy gap -- is found to maximize the ground state probability compared with other adiabatic methods while only requiring knowledge of the lowest $\sim N$ of the $2^N$ Hamiltonian eigenvalues. We also demonstrate that the ground state ordering can be experimentally identified as the most probable of all possible spin configurations, even when the evolution is highly non-adiabatic.
Community Empowerment through Establishment of a Local Food Supply Chain
Creators: name: Molla Ahmadi Dehaghi, Helia
name: Vizcarra Ganoza, Diego
name: Driva, Spyridoula
Publisher: name: Hannover : Leibniz Universität Hannover, Institut für Umweltplanung
Year: 2019
Subjects: subject: Economic crisis
subject: Resilience
subject: Urbanism
subject: Dewey Decimal Classification::700 | Künste, Bildende Kunst allgemein::710 | Landschaftsgestaltung, Raumplanung

description: The socio-economic crisis and its consequences in the “Post-austerity” era in Greece have increased the number of homeless and unemployed people (ATHENS RESILIENCE STRATEGY 2017: p. 12). The increasing number of vulnerable people in Athens are not capable of providing healthy food and require social support to adapt to the new living conditions. This study project seeks to cope with the economic crisis and the challenges that threaten the most vulnerable groups of the society by improving their socio-economic resilience via creating and promoting an alternative self-sustaining local food supply chain. Exarcheia neighborhood in the inner city of Athens is chosen as the case study of this project. This study suggests a network of activities and places in Exarcheia neighborhood, in which urban gardens and farms are built and farmer’s markets and collective kitchens are organized. This network of places and people are supposed be managed by grass-roots initiatives with a special focus on empowering and supporting vulnerable groups of people in Exarcheia. The effect of such local food supply chain is reducing the expenses of food production and supply by omitting the middlemen, gaining affordable and healthy food and increasing the social capital in the neighborhood by boosting the interaction of different groups of inhabitants in the neighborhood and finally improving the quality of life of the inhabitants.
Methoden zur skalenübergreifend hochaufgelösten Erfassung und Quantifizierung von Bodenerosion durch Wasser
Creators: name: Steinhoff-Knopp, Bastian
name: Eltner, Anette
name: Hake, Frederic
name: Paffenholz, Jens-André
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2019
Subjects: subject: Bodenerosion
subject: terrestrisches Laserscanning
subject: UAV-Photogrammetrie
subject: 3D-Punktwolken
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau::624 | Ingenieurbau und Umwelttechnik

description: Bodenerosion durch Wasser ist ein weltweit auftretendes Phänomen und beschreibt den durch menschliche Bewirtschaftung ausgelösten oder verstärkten Bodenabtrag auf landwirtschaftlichen Flächen durch oberflächlich abfließendes Wasser. Die Quantifizierung des abgetragenen Bodenmaterials ist eine methodische Herausforderung an der Schnittstelle zwischen den Fachbereichen Geographie und Landschaftsökologie sowie Geodäsie und Photogrammetrie. Abschätzende Methoden bilden die Grundlage für Monitoringprogramme mit einer Flächenabdeckung von mehreren 100 ha. Moderne Methoden zur Generierung von hochaufgelösten dreidimensionalen (3D)-Punktwolken ermöglichen die mikroskalige Erfassung der Bodenoberfläche und damit auch die hochgenaue Abbildung von Erosionsformen. Zur Datenaufnahme werden terrestrische Laserscanner und unmanned aerial vehicles (UAV)-gestützte photogrammetrische Methoden eingesetzt. In diesem Beitrag werden auf verschiedenen Skalen anwendbare Methoden zur Erfassung von Erosionsformen und der anschließenden Quantifizierung des Bodenabtrags vorgestellt. Herausforderung und Nutzen einer hochauflösenden und mm-genauen Vermessung der Bodenoberfläche zur differenzierten Betrachtung verschiedener Erosionsprozesse werden aufgezeigt. Besondere Betrachtung finden hier die Herausforderungen durch Maskierung durch andere Bodenprozesse sowie die Rolle und der Einfluss der Geo-Referenzierung der 3D-Punktwolken unterschiedlicher Standpunkte des Laserscanners bzw. der geflogenen Trajektorie bei der UAV-Photogrammetrie. Abschließend werden verschiedene (halb-)automatisierte Verfahren zur Bestimmung von Ausräumvolumina auf der Basis von 3D-Punktwolken, erzeugt mittels Laserscanner und UAV-Photogrammetrie, diskutiert.
eDhanvantari: Revolutionizing Healthcare with a Cloud-Based EHR Platform
Creators: name: Sahasrabuddhe, Sneha
name: Sahasrabuddhe, Mandar
name: Yengul Roshan
name: Gokhale, Gauri
Publisher: name: Zenodo
Year: 2023
Subjects: EHR
EMR
HealthTech
eDhanvantari
KBAPL
Indian Healthcare
ABDM

description: This white paper explores the transformative impact of eDhanvantari, a cloud-based, lightweight Electronic Health Record (EHR) platform designed specifically for healthcare professionals in India. With its web and mobile applications, customizable case-papers, telehealth support, and integration with the Ayushman Bharat Digital Mission, eDhanvantari is leading the way in making medical practices paper-free and efficient. This paper discusses the key features and benefits of eDhanvantari and highlights its recognition as the " MEITY-NASSCOM Startup Women Entrepreneur Award – Healthcare" in 2019. It also explores how the integration with Ayushman Bharat Digital Mission further enhances its value in improving healthcare services in India.
title: Морфологические особенности строения средней трети мочеточника
Creators: name: Аббасов, Мирза
name: Сулиманов, Рушан
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2019

description: Проведено изучение морфологических особенностей строения различных отделов средней трети мочеточника на 105 гистологических препаратах. При выполнении анатомических исследований были соблюдены все этические нормы, предусмотренные законодательством Российской Федерации (заключение комитета по этике ГОУ ВПО «СибГМУ Росздрава» №670 от 19.11.2007 г.). Установлено, что проксимальный и дистальный отделы средней трети мочеточника между собой достоверно не отличались. В пейсмекерной зоне отмечалось достоверное увеличение удельного веса мышечной ткани (P˂0,05), за счет чего отмечалось достоверное уменьшение (P ˂ 0,05) остальных показателей (слизистая оболочка, подслизистый слой и двентициальная оболочка). При этом в структуре мышечного слоя достоверно возросло число мышечных волокон, что привело к достоверному уменьшению соединительнотканных элементов, а соответственно, и к достоверному увеличению коэффициента Км/с = 7,6±0,27 (P ˂ 0,05). Полученные результаты свидетельствовали о значимости пейсмекерной зоны в обеспечении пропульсивной функции мочеточника и уродинамики.
title: Белки клеточной адгезии, комплемента и катепсин G в саморегуляции функций кишечного эпителия
Creators: name: Замолодчикова, Татьяна
name: Свирщевская, Елена
name: Котов, Александр
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2019

description: Инициирующий компонент классического пути активации комплемента — C1q, является фактором воспалительного процесса и может играть роль в регуляции гомеостаза и защитных реакций в кишечном эпителии с потенциальным участием регуляторной протеазы катепсина G и белков клеточной адгезии — кадгеринов. С целью установления предполагаемой роли была исследована клеточная локализация C1q в воспалённой слизистой оболочке двенадцатиперстной кишки человека (СОДПК) (дуоденит II-III степени) методом конфокальной микроскопии с использованием специфических антител. Полученные результаты свидетельствуют о выраженном присутствии С1q в различных зонах СОДПК — как в эпителиальном слое, так и в собственной пластинке. С1q был выявлен также в подслизистом слое в зоне расположения дуоденальных (бруннеровых) желёз. Ко-локализация C1q, катепсина G и кадгеринов свидетельствует об их возможном взаимодействии при участии в регуляции тканевого метаболизма, модификации и поддержании барьерных свойств кишечного эпителия при развитии защитного и/или патологического процессов.
Aggregate geometry in amyloid fibril nucleation
Creators: name: Irbäck, A.
name: Jónsson, S. Æ.
name: Linnemann, N.
name: Linse, B.
name: Wallin, S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We present and study a minimal structure-based model for the self-assembly of peptides into ordered beta-sheet-rich fibrils. The peptides are represented by unit-length sticks on a cubic lattice and interact by hydrogen bonding and hydrophobicity forces. By Monte Carlo simulations with >100,000 peptides, we show that fibril formation occurs with sigmoidal kinetics in the model. To determine the mechanism of fibril nucleation, we compute the joint distribution in length and width of the aggregates at equilibrium, using an efficient cluster move and flat-histogram techniques. This analysis, based on simulations with 256 peptides in which aggregates form and dissolve reversibly, shows that the main free-energy barriers that a nascent fibril has to overcome are associated with changes in width.
description: 4 pages
Sesquiterpene Cyclases from the Basidiomycete Cerrena unicolor
Creators: name: Püth, Nils
name: Ersoy, Franziska
name: Krings, Ulrich
name: Berger, Ralf G.
Publisher: name: Basel : MDPI
Year: 2021
Subjects: subject: sesquiterpenes
subject: terpene cyclases
subject: metal ion dependency
subject: phylogenetic analysis
subject: heterologous expression
subject: Cerrena unicolor
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Hundreds of terpenoids have been isolated from Basidiomycota, among them are volatile mono- and sesquiterpenes with amazing sensory qualities, representing a promising alternative to essential oils from endangered plant species. Sesquiterpene synthases (STS) appear to be an abundant class of enzymes in these fungi. The basidiomycete Cerrena unicolor, a known sesquiterpene producer, was in silico screened for sesquiterpene cyclases via homology Basic Local Alignment Search Tool searches. Cyclase genes identified were cloned and heterologously expressed in Escherichia coli Bl21 using pCOLD I as the expression vector. Ten cyclases were successfully produced and purified, and their identity was confirmed using amino acid sequencing of tryptic peptides by nano-liquid chromatography-high resolution-electrospray ionization-tandem mass spectrometry. Gas chromatography/mass spectrometry analysis was applied to characterize these cyclases according to the formation of sesquiterpene hydrocarbons and oxidized terpenoids. Bioinformatic characterization and phylogenetic determination allowed for the classification of these diverse fungal enzymes. A representative single and a multi-product STS, respectively, were further analyzed for their dependency from divalent metal cations as a cofactor for the catalytic activity.
Macroscopic quantum tunneling of magnetization explored by quantum-first-order reversal curves (QFORC)
Creators: name: Béron, Fanny
name: Novak, Miguel A.
name: Vaz, Maria G. F.
name: Guedes, Guilherme P.
name: Knobel, Marcelo
name: Caldeira, Amir
name: Pirota, Kleber R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A novel method to study the fundamental problem of quantum double well potential systems that display magnetic hysteresis is proposed. The method, coined quantum-first-order reversal curve (QFORC) analysis, is inspired by the conventional first-order reversal curve (FORC) protocol, based on the Preisach model for hysteretic phenomena. We successfully tested the QFORC method in the peculiar hysteresis of the Mn12Ac molecular magnet, which is governed by macroscopic quantum tunneling of magnetization. The QFORC approach allows one to quickly reproduce well the experimental magnetization behavior, and more importantly to acquire information that is difficult to infer from the usual methods based on matrix diagonalization. It is possible to separate the thermal activation and tunneling contributions from the magnetization variation, as well as understand each experimentally observed jump of the magnetization curve and associate them with specific quantum transitions.
description: 15 pages, 5 figures