cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Myeloperoxidase Mediated Protection in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastatic spread of cancer cells is the principle cause of death for breast cancer patients. Recent epidemiological studies link a high expressing genotype for myeloperoxidase (MPO) to a twofold reduction in risk of recurrent breast cancer in patients undergoing chemotherapy. MPO is an enzyme present in white blood cells that produces oxidants, including bleach, which function to kill invading microbes. The observation that patients with high expressing MPO genotypes are at less risk for cancer recurrence suggests that MPO oxidants help to kill residual tumor cells. Our recent findings show that MPO is aberrantly expressed in breast cancer cells, leading to the hypothesis that MPO oxidants could directly kill tumor cells, and this could reduce the risk of tumor recurrence.

 We propose to test this hypothesis, and verify the epidemiological studies, using a mouse model for breast cancer that carries the human MPO gene. We propose to treat the mice with chemotherapy cyclophosphamide (CPA) and tamoxifen, as was used in the human clinical studies, and determine if MPO enhances the tumoricidal activities of CPA. This will be accomplished by cross-breeding mice carrying a gene which makes them susceptible to breast cancer to our mouse strain carrying the human MPO gene.

 MPO expression in tumor cells, as well as in tumor associated macrophages (TAM) and neutrophils, will be monitored along with markers of apoptosis, MPO-dependent oxidation, and biomarkers of tumor progression such as Neu, estrogen receptor (ER), or cyclin D1 (cell cycle regulation). Next, CPA and tamoxifen will be injected or added to the water/food supplied to the mice. The mice will be monitored for tumor growth and metastasis, and at the end of the experiment, tumor size and grade/histology will be analyzed.

 The finding that MPO is expressed at high levels in some human breast carcinoma cells is a novel and potentially important discovery. MPO expression is normally restricted to bone marrow myeloid precursors. The aberrant expression in breast cancer cells is likely to impact survival of the cancer cells, and this could lead to novel therapeutics aimed at enhancing MPO expression and oxidant generation, thereby enhancing the efficacy of chemotherapy.
Additional file 13: of Applying systems biology to biomedical research and health care: a prĂŠcising definition of systems medicine
Creators: name: Schleidgen, Sebastian
name: Fernau, Sandra
name: Fleischer, Henrike
name: Schickhardt, Christoph
name: Ann-Kristin OĂA
name: Winkler, Eva
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Inductive assigning of remaining ends to preliminary categories (DOCX 30 kb)
Glossodoris Ehrenberg 1831
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Glossodoris

description: Glossodoris sp. 3
(Figure 5 G)
Material examined. Four specimens. MHN-YT1237, 2 spcs., POD, 11 May 2014, 14m, 14 and 4mm; MB28- 0 0 4861, POB, 12 May 2014, 15m, 12mm; MB28-004898, NKA, 10 Jun. 2014, 30m, 24mm.
Habitats. Subtropical rocky reefs and tropical coral reefs.
Occurrences. Ponta do Ouro and Nuarro.
Geographic distribution. Indo-west Pacific. Japan (Gosliner et al. 2008), South Africa (Rudman 2000) and Mozambique.
Remarks. This species appears to be undescribed (Gosliner et al. 2008) and has not been included in the work of Matsuda & Gosliner (2017).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 24, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Podosomes/Invadopodia in breast cancer metastasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the mechanisms cancer cells use to invade other tissues is by forming special structures on the cellular membrane called podosomes, which are dynamic, actin-rich adhesion structures in a variety of cell types. Because podosomes are found mainly in motile cells and control the activity of matrix metalloproteases, they are thought to contribute to tissue invasion. My mentor’s lab (Dr. Sara Courtneidge) recently identified a key molecule in podosomes, called Tks5, and showed that when the expression of Tks5 is reduced, it will inhibit cellular movement and invasion. Even though it was shown that Tks5 expression correlated with the invasiveness of breast cancer cell lines and tumor biopsies, it is still unclear how Tks5 contributes to breast cancer progression, especially in advanced tumor models.

 My first goal is to characterize the primary tumors and lung metastasis of the PyMT mouse for Tks5 expression and test whether Tks5 expression in these tumors correlates with invasiveness and tumor progression. The PyMT mouse model consistently develops mammary tumors with associated lung metastases. I will also test the function of Tks5 in different cell types that are present in the tumor. Next, I will study how deletion of Tks5 in tumor cells and different cell types in the tumor-supporting stroma will affect tumor growth and metastasis. We will use immunohistochemstry to analyze tumor sections (primary and metastasis) of the PyMT mice for Tks5 expression. Next, I will use siRNA technology to reduce Tks5 expression in different cell cultures (epithelial cells, fibroblasts, myeloid cells and endothelial cells) obtained from both primary and lung metastasis of the PyMT mouse. Altered Tks5 levels in cells will be correlated with podosome function using cell invasion assays. In order to study differences between tumor formation and metastasis, I will reduce the expression of Tks5 in carcinoma cell lines derived from the PyMT tumors (primary and lung metastasis) using short hairpin RNA technology and either implant these cells in the fat pad or inject cells in the tail vein of mice. Finally, I will create transgenic mice of the PyMT model in which Tks5 is deleted in specific tissues using the CreLoxP mouse model system.

 This research will clarify how Tks5 and podosome formation contributes to tumor progression in breast cancer.
Additional file 1: Table S1. of Dietary patterns, gender, and weight status among middle-aged and older adults in Taiwan: a cross-sectional study
Creators: name: Muga, Miriam
name: Owili, Patrick
name: Chien-Yeh Hsu
name: Hsiao-Hsien Rau
name: Chao, Jane
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Factor loadings of 22 foods or food groups. (DOCX 16 kb)
Apagomerina rubricollis Galileo & Martins 1992
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Apagomerina
Apagomerina rubricollis

description: 39. Apagomerina rubricollis Galileo & Martins, 1992: 142, fig. 2 Holotype, male
Type locality. Brazil, Rondônia: Vilhena, 22.X.1986, C. Elias
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 346, DOI: 10.5281/zenodo.250291
Goniobranchus albonares
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus albonares

description: Goniobranchus albonares (Rudman, 1990)
(Figure 5 H)
Material examined. Seven specimens. MB28-004503, ZRP, 21 Feb. 2012, 2m, 5mm; MB28-004 551, ZRP, 21 May 2012, 2m, 5mm; MB28-004624, ZGWS, 0 8 Oct. 2012, 16m, 25mm; ZMBN117045, PACG, 0.5m, 22mm; MHN-YT1052, ZRP, 18 Dec. 2013, 0.5m, 6mm; MB28-004789, ZRP, 0 5 Jan. 2014, 0.3m, 9mm; ZMBN119693, 10 Oct. 2014, ZRP, 1m, 5mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Zavora and Paindane.
Geographic distribution. Indo-west Pacific. Japan (Gosliner et al. 2008), New Caledonia, Australia (Rudman 1990), Réunion (Bidgrain 2006a), Madagascar (Rassat, 2016a), Mayotte (Schubert 2010) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 24, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Evidence of nearshore summer upwelling off Atlantic City, New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1984

description: Analysis of nearshore ocean temperature data collected in the floatwell of a tide gauge on Steel Pier and wind data collected at the Atlantic City, New Jersey, weather station during summer months of 1981 shows a strong correlation between major cooling or warming events in the water and the strength of upwelling or downwelling wind components one day earlier.
New Jersey bald eagle project, 2011
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2011

description: The Division of Fish and Wildlife’s Endangered and Nongame Species Program (ENSP) biologists and volunteer observers located and monitored bald eagle nests and territories. A new record high of 113 eagle pairs was monitored during the nesting season; 95 of those were active (with eggs). New Jersey’s Delaware Bay region remained the state’s eagle stronghold, with 60% of all nests located in Cumberland and Salem counties. Twenty-two new eagle pairs were found this season, 16 in the south, two in central and four in northern NJ. Seventy-one (75%) nests were successful in producing 119 young, for a productivity rate of 1.25 young per active nest. Twenty-four (25%) nests failed to fledge young.In January’s Midwinter Eagle Survey, ENSP staff, regional coordinators and volunteers reported a total of 238 bald eagles, down by 27% from 2010’s record count. Forty-one eagles were recorded in northern NJ and 197 in the south.The state’s eagle population would not be thriving without the efforts of the dedicated eaglevolunteers who observe nests, report sightings, and help protect critical habitat.
Murupeaca pinimatinga Martins & Galileo 1992
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Murupeaca
Murupeaca pinimatinga

description: 40. Murupeaca pinimatinga Martins & Galileo, 1992a: 576, fig. 1 Holotype, male
Type locality. Brazil, Mato Grosso: Rosário Oeste, X.1972, Hümmelgen
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 346, DOI: 10.5281/zenodo.250291
Transnasal Treatment of Chemokine Analogs for NeuroAIDS.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Effective highly-active antiretroviral therapy (HAART) has helped human immunodeficiency virus (HIV)-infected patients survive longer. However, the inefficient penetrance of HAART drugs into the brain has resulted in an increased prevalence of HIV-associated dementia (HAD). Currently, there is no effective therapy for HAD. The pathogenesis of HAD is attributable to HIV proteins such as gp120. We and others have demonstrated that gp120 causes its detrimental effects via HIV co-receptors, CXC chemokine receptor 4 (CXCR4) and CC chemokine receptor 5 (CCR5). Thus, these receptors are attractive targets for HAD therapy. Along this line, we developed new peptide inhibitors (termed synthetically and modularly modified (SMM)-chemokine analogs). We here aim to test their efficacy in a HAD animal model. Specifically, we propose to investigate whether transnasal application of SMM-chemokine analogs restores the proliferation of adult neural progenitors in a HAD mouse model which expresses gp120 in the brain. We recently found a significant decrement in proliferation of adult neural progenitors in gp120/HAD mice similar to that previously observed in the brains of human HAD patients. Adult neurogenesis has been postulated to be important for the processes of learning and memory. Thus, the decrement in adult neurogenesis is, at least in part, relevant to HAD. Importantly, peptides can be delivered into the brain via transnasal application. Furthermore, transnasal administration of SMM-chemokine analogs is associated with non-invasiveness and ease of application that encourage this proposal as a viable strategy for delivering peptide antagonists like SMM-chemokine analogs into patients. Thus, this study proposes to investigate a noninvasive strategy/therapy targeted for HAD patients using a small animal model of HAD.
Chemical Inhibitors of Hsp70 for Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is a critical problem that chemotherapy drugs are often ineffective for treatment of advanced breast cancer. Endogenous protection mechanisms within breast cancer cells often blocks effective chemotherapy treatment. Heat shock protein 70 (Hsp70) represents one of critical cell protection proteins in breast cancer. Normal cells contain few Hsp70 molecules. However, the amount of Hsp70 molecules in breast cancer is increased hundreds of times over that of normal cells. Therefore, breast cancer cells can escape the toxicity of chemotherapy drugs, in part, because they contain too much protective Hsp70. The purpose of this research is to generate chemical inhibitors of Hsp70 that might eventually be used as new drugs for treating breast cancer.

 By generating chemicals that selectively inhibit Hsp70, we will be able to directly test this hypothesis and begin the process of creating new drugs for breast cancer therapy. To identify chemicals that inhibit Hsp70, we will use robotic instrumentation to screen a large collection (i.e., library) of chemicals, which each have a different shape (structure). This empirical search is expected to yield a small number of molecules that have just the right shape to bind to surface features of the Hsp70 protein. Then, the active chemicals will be modified by to adjust their shape, so they bind more avidly to the surface of Hsp70, thus increasing the chances of inhibition. In addition, the structural optimization of Hsp70 inhibitors will be assisted by modern techniques of structure-based drug discovery, especially using high-field nuclear magnetic resonance (NMR) and computer modeling. This allows a state-of-the-art visualization of the 3-dimensional structure of Hsp70 with chemical inhibitors bound to it. Finally, the chemical inhibitors of Hsp70 will be tested for their ability to kill breast cancer cells in culture, when used alone or in combination with anti-cancer drugs, such as Taxotere and Adriamycin. Ultimately, we will be poised to advance the best of our Hsp70 inhibitors into animal models of breast cancer, to more definitively test their anti-tumor activity as well as toxicity.

 To date, potent Hsp70 inhibitors have never been produced or tested as cancer therapies. However, recently it was shown that chemicals that inhibit a molecule with similar functions, called Hsp90, have anti-tumor activity and an acceptable safety profile. Hsp90 inhibitors are now in Phase II clinical trials for refractory cancers. These recent advances make it more likely that this project will succeed and advance a new breast cancer target and drug strategy closer to eventual translation.
Moema cendi Martins & Galileo 1992
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cyprinodontiformes
Rivulidae
Moema
Moema cendi

description: 41. Moema cendi Martins & Galileo, 1992b: 595, fig. 5 Holotype, female
Type locality. Costa Rica, Cartago: Turrialba (600 m), 09.V.1973, V.O. Becker Current name. Neomoema cendi (Martins & Galileo, 1992)
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 346, DOI: 10.5281/zenodo.250291
THS Chemistry: Exposure assessment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Our group has contributed to the development of the Thirdhand Smoke (THS) Consortium by describing indoor chemical processes that dominate exposures to THS. We have studied the critical role of indoor reactions of THS constituents with oxidants and nitrosating agents commonly found indoors. The identification and quantification of inhalable THS constituents enabled the assessment of their health impacts. Sampling and analytical methods were developed to expand the scope of THS constituents that can be measured. More recently, we initiated a study to evaluate the efficiency and potential risks associated with releasing high levels of ozone as a THS remediation approach. We have also collaborated with other Consortium partners in the evaluation of THS biological effects. On this new phase of the Consortium, we intend to extend our research on these areas by: Aim 1: Quantify intake of carcinogenic tobacco-specific nitrosamines (TSNAs) via the main exposure routes (dermal, dust ingestion, inhalation), to better implement protective measures and THS remediation strategies. Our approach will involve a combination of experimental methods to assess dermal uptake, and modeling incorporating recently published information on TSNAs levels in THS. We hypothesize that TSNAs can form directly on the skin by nitrosation of nicotine, and contribute significantly to total exposure to these harmful compounds. Aim 2: Develop a THS diagnostic tool for untrained non-professional users, based on measurement of airborne nicotine. Quantifying accurately very low levels of nicotine in indoor air is a useful tool to assess THS contamination, because it integrates emissions from multiple sources. Samplers will trap nicotine on a bisulfate-coated filter connected to a miniature battery-operated pump and flow sensor with continuous logging capabilities. The method will be validated in the lab, and deployed alongside other THS diagnostic tools in field measurements led by SDSU. We intend to increase our ability to detect trace levels of nicotine by 1-2 orders of magnitude with respect to the current practice using bisulfate-coated filters. Aim 3: Contribute to Consortium-wide efforts to assess remediation strategies by evaluating the efficacy of carpet replacement in THS-contaminated homes that are being cleaned and conditioned for rent or sale. Air and surface samples will be measured before and after a new carpet is installed, to quantify the impact of source elimination. The THS-contaminated carpet and padding materials will be installed at LBNL's room-sized chamber and used in ozonation experiments. An ozone generator commonly used in homes by companies providing cleaning and restoration services will be used to assess short- and long-term effects, including formation of airborne and surface-bound oxidation byproducts.
Genetic Susceptibility to Thirdhand Smoke Effects
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Thirdhand smoke (THS) has gained public attention in recent years but its health impact is largely unknown. During the last six years of research within the Consortium, we have shown that exposure to THS or its specific chemical constituent NNA causes damage to cellular genetic material (DNA) with covalent binding, changes in cellular metabolites and tumor-forming properties; exposure at early age in mice resulted in significant developmental, immunological abnormalities and lung cancer formation. The goal of this sub-project is to study genetic factors for individual susceptibility to THS-induced effects, especially tumor development, and to develop biomarkers in animal studies and human samples, with an emphasis on carrying out laboratory studies that will help in translating findings to human practice and the public. We hypothesize that (I) genetic susceptibility influences disease risk of THS exposure; (2) the NNA-induced deoxyguanosine (dG)-binding adduct is a biomarker (a tracer of harm inside the body) for THS exposure and the adduct level is associated with disease risk. We will employ an integrative systems biology approach for this project by using the generally diverse Collaborative Cross (CC) mouse resource that recapitulates the genetic diversity of the human population. In Aim 1 we will first investigate the tumor incidence across 20 THS-exposed CC strains and then perform genetic analysis to identify individual genetic susceptibility to these biological and health effects of THS exposure. Translational implications include (1) developing useful animal models for predicting health risk of THS exposure in human population; (2) using genome-wide association analysis together with RNA-sequencing, we will identify gene biomarkers for genetic susceptibility to THS effects, and find related human homologs of these mouse genes that can be used to predict and study human disease risk induced by THS; and (3) identify molecular mechanism for THS-induced disease for ultimately developing strategies for disease prevention and treatment. In Aim 2, we will develop a quantitative LC-MS/MS method for the validation of the NNA adduct 1,N2-NNA-dG as a specific biomarker for THS exposure and indicator of cancer risk in both animals and humans. We will determine whether iso-NNAC is an NNA metabolite in vitro with human liver homogenates. For biomarkers we will perform proof-of-concept studies using available human specimen. Such translational studies will provide novel evidence of THS impact on cancer development in general population and how individual genetics affect vulnerability, and to use both basic science and translational findings to reduce the THS impact in exposed humans and to support policy modeling and development.
New Jersey bald eagle project, 2012
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2012

description: The Division of Fish and Wildlife’s Endangered and Nongame Species Program (ENSP) biologists and volunteer observers located and monitored bald eagle nests and territories. A new record high of 135 eagle pairs was monitored during the nesting season; 119 of those were active (with eggs). New Jersey’s Delaware Bay region remained the state’s eagle stronghold, with 45% of all nests located in Cumberland and Salem counties. Twenty-seven new eagle pairs were found this season, 15 in the south, 2 in central and 10 in the north. One hundred nests (84%) were successful in producing 165 young, for a productivity rate of 1.39 young per active nest. The outcome of four active nests was unknown. Fifteen (13%) nests failed to fledge young.In January’s annual Midwinter Eagle Survey, ENSP staff, regional coordinators and volunteers reported a record total of 335 bald eagles. Forty-five eagles were recorded in northern NJ and 290 in the south.The state’s eagle population would not be thriving without the efforts of the dedicated eagle volunteers who observe nests, report sightings, and help protect critical habitat.
New Jersey bald eagle project, 2013
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2013

description: The Division of Fish and Wildlife’s Endangered and Nongame Species Program (ENSP) biologists, Conserve Wildlife Foundation staff and volunteer observers located and monitored bald eagle nests and territories. One hundred forty-eight nest sites were checked during the nesting season, of which 119 were documented to be active (with eggs), nine were territorial or housekeeping pairs, and 20 were unknown or the pair could not be found. Fourteen new eagle pairs were found this season, seven in the south, one in central and six in northern NJ. Ninety-six nests (81%) of the 119 known-outcome nests produced 177 young, for a productivity rate of 1.49 young per active nest. The outcome of six active nests was unknown. Seventeen (14%) nests failed to fledge young. New Jersey’s Delaware Bay region remained the state’s eagle stronghold, with 41% of all nests located in Cumberland and Salem counties.In January’s annual Midwinter Eagle Survey, ENSP staff, regional coordinators and volunteers reported a total of 297 bald eagles. Thirty-three eagles were recorded in northern NJ and 264 in the south.The state’s eagle population would not be thriving without the efforts of the dedicated eagle volunteers who observe nests, report sightings, and help protect critical habitat.
Goniobranchus albopunctatus Garrett 1879
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus albopunctatus

description: Goniobranchus albopunctatus Garrett, 1879
(Figure 5 I)
Material examined. One specimen. MB28-004819, 0 7 May 2014, POA, 15m, 24mm.
Habitats. Subtropical rocky reef.
Occurrences. Ponta do Ouro.
Geographic distribution. Indo-west, central Pacific. Society Islands (Garret 1879), Hawaii, Japan, Marshall Islands, Australia, Indonesia, Philippines, Seychelles, Tanzania, South Africa (Gosliner et al. 2008) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 24, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Additional file 14: of Applying systems biology to biomedical research and health care: a prĂŠcising definition of systems medicine
Creators: name: Schleidgen, Sebastian
name: Fernau, Sandra
name: Fleischer, Henrike
name: Schickhardt, Christoph
name: Ann-Kristin OĂA
name: Winkler, Eva
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Application of the six adequacy criteria to the means of Systems Medicine (DOCX 30 kb)
Juninia beckeri Martins & Galileo 1992
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Juninia
Juninia beckeri

description: 42. Juninia beckeri Martins & Galileo, 1992a: 577 Holotype, female
Type locality. Costa Rica, Cartago: Turrialba, 15.V.1972, V.O. Becker Current name. Sibapipunga beckeri (Martins & Galileo, 1992)
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 346, DOI: 10.5281/zenodo.250291
Settler histories of place
Creators: name: Falzetti, Ashley
Publisher: name: No Publisher Supplied
Year: 2014

description: Frances Slocum has become the most famous Miami Indian woman in history, which is surprising because she was born to a white Quaker family.  This project traces the formation of her captivity narrative as she is transformed into a figure of local history in two distinct places: Wilkes-Barre, Pennsylvania where she was captured and Peru, Indiana where she lived and was buried.    Settler Histories of Place examines the periods in which her narrative gains popularity and finds that her story circulates most widely at moments when there are broader movements to take control of Miami Indian lands in Indiana.  How storytellers describe her racial identity shapes how she is imagined as a historical figure of settler and native history.  What details are included or omitted shapes how the violence of settling the United States is imagined.  Narratives about Frances Slocum are used in two particular regions as key historical stories of place.  These stories use racial descriptions to naturalize a settler sense of belonging, normalizing settler claims to land inhabited by the Miami.  Accounting for Miami perspectives of Frances Slocum disrupts settler narratives of Miami absence and reveals the cultural logics of public history in a settler-context.
Woytkowskia gruberi Martins & Galileo 1992
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Woytkowskia
Woytkowskia gruberi

description: 43. Woytkowskia gruberi Martins & Galileo, 1992b: 592 Holotype, male
Type locality. Costa Rica, Cartago: Turrialba (600 m), 10.IV.1973, V.O. Becker
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 346, DOI: 10.5281/zenodo.250291
Role of p68 in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Two major challenges in diagnosis and therapy of breast cancer lie in variations among tumors and their resistance to drug treatment. The molecular pathways underlying these have not been worked out. In our preliminary studies, we found that high expression of a protein called p68 (also called DDX5) is associated with aggressiveness and drug resistance of breast cancer cells. We and others have found that p68 is involved in a complex interacting network in the cell. Strikingly, p68 was recently shown to be one of the two resistance genes for lung cancer cells during camptothecin (topoisomerase inhibitor) treatment. In this project, we will further define the role of p68 in breast cancer, with particular emphasis on invasion and drug resistance.

 We hypothesize that p68 is a key molecular marker contributing to breast cancer heterogeneity, and can be used to stratify tumor aggressiveness and drug resistance. Since p68 has been shown to interact with several key proteins in breast cancer, we will study how p68 regulates the interacting network and therefore influences drug responses. For these studies we will combine detailed biochemical characterization of p68 with a systems biology approach to elucidate its signaling networks in breast cancer. We will modulate the expression of p68 in several breast cancer cell lines using RNAi (inhibition) and gene transfection (increased expression). We will then investigate the effects on invasion and on responses to several commercially available drugs. Finally, we will begin to characterize the reprogramming of p68 signaling network through profiling of interactome (i.e., whole set of molecular interactions in cells), transcriptome (i.e., the set of all messenger RNA molecules), and proteome (all protein constituents).

 There is a good chance that p68 may contribute to personalized medicine by serving as a clinically useful molecular marker to characterize breast cancer subtypes, as a predictor for drug resistance, and it may serve as a drug target for a combinational therapy to circumvent the drug resistance commonly seen in aggressive tumors.
Goniobranchus alderi
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus alderi

description: Goniobranchus cf. alderi (Collingwood, 1881)
(Figure 5 J)
Material examined. Eight specimens. MHN-YT87, ZGWS, 10 Dec. 2011, 20m, 25mm; MB28-0 0 4446, ZWH, 0 2 Feb. 2012, 20m, 44mm, collected by S. Bruck; MB28-004620, ZJS, 29 Aug. 2012, 12m, 28mm, collected by J.
Bergman; MB28-004685, ZM, 29 Aug. 2012, 8m, 44mm; MB28-004730, ZD, 18 Aug. 2013, 32m, 20mm; ZMBN117052, 0 6 Jan. 2014, 51m, 26mm; ZMBN119694, ZGWS, 11 Oct. 2014, 19m, 34mm; ZMBN119695, ZA 51, 12m, 38mm.
Habitats. Subtropical rocky reefs and wreck.
Occurrences. Zavora.
Geographic distribution. Western Indian Ocean. Seychelles, Madagascar, South Africa (Gosliner et al. 2008) and Mozambique.
Remarks. This morphotype is part of the Chromodoris tinctorius complex, which needs to be reviewed (Gosliner et al. 2008, 2015). All the specimens examined have identical colour patterns and appear to be the same species. The dorsal colour is white with a red reticulate pattern. The mantle margin is yellow. The rhinophores stalk is white and the lamellae are red-purple, lined in white. The ventral part of the foot is solid white. The dorsal part of the foot is white with red dots. This morphotype appears to be typical of western Indian Ocean specimens (Gosliner et al. 2008).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 24-25, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Cacostola cana Marinoni & Martins 1982
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Cacostola
Cacostola cana

description: 44. Cacostola cana Marinoni & Martins, 1982: 249, fig. 2 Holotype, male
Type locality. Brazil, Espírito Santo: Linhares, 21-30.X.1973, C.T. & C. Elias
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
Goniobranchus alius
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus alius

description: Goniobranchus alius (Rudman, 1987)
(Figure 5 K–L)
Material examined. Ten specimens. MHN-YT10, ZRP, 17 Jun. 2011, 1m, 14mm; MB28-004539, ZRP, 0 6 May 2012, 2m, 14mm, collected by S. Bruck; MB28-004540, ZRP, 0 6 May 2012, 2m, 9mm, collected by S. Bruck; ZMBN117024, ZRP, 0 6 May 2012, 2m, 8mm; ZMBN117058, ZRP, 16 Apr. 2014, 0.5m, 16mm; ZMBN11 7063, POD, 11 May 2014, 15m, 16mm; MB28-004864, 2 spcs., POB, 16m, 6-8mm; MB28-0 0 4983, ZSC, 25 Apr. 2015, 20m, 15mm; MB28-005018, ZRP, 0 4 Aug. 2015, 1m, 16mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Ponta do Ouro and Zavora.
Geographic distribution. Indian Ocean. Sri Lanka (Yonow 1984), Tanzania, Réunion Island (Rudman 1987), Madagascar, South Africa (Gosliner et al. 2008) and Mozambique.
Remarks. Specimens show colour variation ranging from a white dorsum with purple mantle edge to a brownish dorsum with light yellow spots inside the purple margin. The latter pattern resembles Goniobranchus aureopurpurus from the West Pacific. Rudman (2005b) suggests that “ G. alius, G. aureopurpureus, G. rufomaculatus and G. albopustulosus ” may be the same species with wide geographic distribution and colour variations.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 25, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Biology and control measures for Aedes albopictus (Skuse), the Asian tiger mosquito, in northeastern USA
Creators: name: Faraji, Ary
Publisher: name: No Publisher Supplied
Year: 2014

description: Aedes albopictus is an invasive species with expanding geographic range and involvement in mosquito-borne diseases. Host selection patterns by invasive mosquitoes are important because they increase endemic disease transmission and drive outbreaks of exotic pathogens. Aedes albopictus has been characterized as an opportunistic feeder but limited information is available on their feeding patterns in temperate regions. Because of the increasing expansion and abundance of Ae. albopictus and the escalating diagnoses of exotic pathogens in travelers returning from endemic areas, I investigated the host feeding patterns of this species in newly invaded areas to elucidate its role in disease ecology and assess the public health threat of an exotic arbovirus outbreak.   In Chapter 1, I report the blood meal results from Ae. albopictus in New Jersey. I found that Ae. albopictus fed exclusively on mammalian hosts with over 90% of their blood meals derived from humans (58%) and domesticated pets (23% cats, 15% dogs). No avian-derived blood meals were detected. The high mammalian affinity of Ae. albopictus suggests that this species will be an efficient vector of mammal- and human-driven zoonoses like dengue and chikungunya viruses but may have limited exposure to endemic avian zoonoses like West Nile virus.    In Chapters 2 and 3, I investigated the penetration, characteristics, and efficacy of a nighttime adulticide application against diurnal populations of Ae. albopictus. Adult control of Ae. albopictus is difficult because the species occurs primarily within cryptic habitats of residential backyards where obstacles such as buildings can disrupt spray plumes and penetration. I collected aerosol droplets consistently from all habitats, with no significant differences detected between locations within the same application rate. Mid label rates displayed similar droplet density values as max label rates in urban areas. Dual applications at mid label rate spaced one or two days apart accomplished significantly higher reduction (85%) than single full rate applications (&3%). Our results demonstrate that nighttime adulticiding is effective in reducing Ae. albopictus abundance and highlight its potential use as part of integrated mosquito management programs and during disease epidemics when reducing human illness is of paramount importance.
Additional file 1: of Applying systems biology to biomedical research and health care: a prĂŠcising definition of systems medicine
Creators: name: Schleidgen, Sebastian
name: Fernau, Sandra
name: Fleischer, Henrike
name: Schickhardt, Christoph
name: Ann-Kristin OĂA
name: Winkler, Eva
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Papers identified through research strategy (DOCX 44 kb)
Hesycha clavata Martins & Galileo 1990
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Hesycha
Hesycha clavata

description: 45. Hesycha clavata Martins & Galileo, 1990: 77 Holotype, male
Type locality. Brazil, Mato Grosso do Sul: Dourados, 29-30.1975, J. Lorenzini
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
Civic engagement among youth aging out of foster care
Creators: name: Forenza, Bradley Anton
Publisher: name: No Publisher Supplied
Year: 2014

description: Youth aging out of foster care constitute a vulnerable and understudied population, for whom civic engagement opportunities are rare. In spite of evidence that suggests civic engagement may be an empowering, developmental process for youth in the general population, few empirical studies have investigated these phenomena among youth aging out of care. This research utilized a qualitative approach to study the intersection of aging out and civic engagement for the betterment of primary prevention services and policy. Utilizing a targeted engagement initiative (Youth Advisory Board) for youth aging out of care in New Jersey, this research analyzed: (1) in-depth interviews/survey data from Youth Advisory Board leaders (who are themselves somewhere in the process of aging out of foster care), (2) in-depth interviews/survey data from civic youth workers (who are paid adults/employees of a local, nonprofit vendor agency that performs work in the area of child welfare), and (3) non-participant observation of Youth Advisory Board meetings, which occurred at five regional memberships throughout the state. Emergent themes revealed that (1) service and activism were discussed and approached in silo, even though both are dimensions of civic engagement; (2) youth reported very high levels of connection to their civic youth workers (adult coordinators who are also professional employees of a local nonprofit), though adults did not report similarly high levels; (3) perceptions of access to, and opportunity derived from, the New Jersey Department of Children and Families were also discussed, in tandem with the notion that (4) youth in this study perceived the Department positively, which may be attributed to the fact that youth in this study had personal connections to departmental officials and administrators. The final emergent theme (5) pertained to the professional goals of this youth sample, whereby activist-oriented and helping profession careers comprised future aspirations.