cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of pharmaceutically scalable inhaled anti-cancer nanotherapy – Repurposing amodiaquine for non-small cell lung cancer (NSCLC)
Creators: name: Parvathaneni, Vineela
name: Kulkarni, Nishant
name: chauhan, Gautam
name: Shukla, Snehal
name: Elbatanony, Rasha
name: Patel, Brijeshkumar
name: Kunda, Nitesh K.
name: Muth, Aaron
name: Gupta, Vivek
Publisher: name: Health Research Alliance
Year: 2025
Subjects: classificationCode: 321404
subject: Pharmaceutical delivery technologies
classificationCode: 321405
subject: Pharmaceutical sciences

description: New drug and dosage form development faces significant challenges, especially in oncology, due to longer
development cycle and associated scale-up complexities. Repurposing of existing drugs with potential anticancer
activity into new therapeutic regimens provides a feasible alternative. In this project, amodiaquine (AQ),
an anti-malarial drug, has been explored for its anti-cancer efficacy through formulating inhalable nanoparticulate
systems using high-pressure homogenization (HPH) with scale-up feasibility and high reproducibility. A
32 multifactorial design was employed to better understand critical processes (probe homogenization speed while formulating coarse emulsion) and formulation parameters (concentration of cationic polymer in external
aqueous phase) so as to ensure product quality with improved anticancer efficacy in non-small cell lung cancer
(NSCLC). Optimized AQ loaded nanoparticles (AQ NP) were evaluated for physicochemical properties, stability
profile, in-vitro aerosol deposition behavior, cytotoxic potential against NSCLC cells in-vitro and in 3D simulated
tumor spheroid model. The highest probe homogenization speed (25,000 rpm) resulted in lower particle size.
Incorporation of cationic polymer, polyethylenimine (0.5% w/v) resulted in high drug loading efficiencies at
optimal drug quantity of 5 mg. Formulated nanoparticles (liquid state) exhibited an aerodynamic diameter of
4.7 ± 0.1 μm and fine particle fraction of 81.0 ± 9.1%, indicating drug deposition in the respirable airways.
Cytotoxicity studies in different NSCLC cell lines revealed significant reduction in IC50 values with AQ-loaded
nanoparticles compared to plain drug, along with significant cell migration inhibition (scratch assay) and reduced % colony growth (clonogenic assay) in A549 cells with AQ NP. Moreover, 3D simulated spheroid studies
revealed efficacy of nanoparticles in penetration to tumor core, and growth inhibition. AQ's autophagy inhibition
ability significantly increased (increased LC3B-II levels) with nanoparticle encapsulation, along with moderate
improvement in apoptosis induction (Caspase-3 levels). No impact was observed on HUVEC angiogenesis suggesting alternative anticancer mechanisms. To conclude, amodiaquine can be a promising candidate for repurposing to treat NSCLC while delivering inhalable nanoparticles developed using a scalable HPH process.
Despite the involvement of complex parameters, application of DoE has simplified the process of product and process optimization.
Platelet-Rich Plasma as an Autologous and Proangiogenic Cell Delivery System
Creators: name: Zahn, Jessica
name: Loibl, Markus
name: Sprecher, Christoph
name: Nerlich, Michael
name: Alini, Mauro
name: Verrier, Sophie
name: Herrmann, Marietta
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: MESENCHYMAL STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; FUNCTIONAL-PROPERTIES; SMOOTH-MUSCLE; HUMAN TISSUES; IN-VITRO; PDGF-B; BONE; ANGIOGENESIS; GROWTH;
subject: 610 Medizin

description: Angiogenesis is a key factor in early stages of wound healing and is crucial for the repair of vascularized tissues such as the bone. However, supporting timely revascularization of the defect site still presents a clinical challenge. Tissue engineering approaches delivering endothelial cells or prevascularized constructs may overcome this problem. In the current study, we investigated platelet-rich plasma (PRP) gels as autologous, injectable cell delivery systems for prevascularized constructs. PRP was produced from human thrombocyte concentrates. GFP-expressing human umbilical vein endothelial cells (HUVECs) and human bone marrow-derived mesenchymal stem cells (MSCs) were encapsulated in PRP gels in different proportions. The formation of cellular networks was assessed over 14 days by time-lapse microscopy, gene expression analysis, and immunohistology. PRP gels presented a favorable environment for the formation of a three-dimensional (3D) cellular network. The formation of these networks was apparent as early as 3 days after seeding. Networks increased in complexity and branching over time but were only stable in HUVEC-MSC cocultures. The high cell viability together with the 3D capillary-like networks observed at early time points suggests that PRP can be used as an autologous and proangiogenic cell delivery system for the repair of vascularized tissues such as the bone.
Moina minuta Hansen 1899
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Moinidae
Moina
Moina minuta

description: Moina minuta Hansen, 1899.
(1) Cova da Mandioca Reservoir, Urandi, 14°46’7”S 42°47’40”W, 06.ii.2002, coll. Patrícia Mitsuka and Raoul Henry (EL00104). (2) Estreito Reservoir, Urandi, 14°49’33”S 42°48’24”W, 06.ii.2002, coll. Patrícia Mitsuka and Raoul Henry. (3) Waterbody near Nova Soure, on the road connecting BR-101 and BR-116, 28.ii.1995, coll. P.S. Young and C.S. Serejo (MNRJ20286). (4) Pond at Pojuca, 12°24’31”S 38°20’40”W, 2019, coll. Rafael L. Macedo (NEL /UNIRIO).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 19, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Lamelliassus chiangmaiensis Dai, Dietrich & Zhang, 2015, sp. nov.
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Lamelliassus
Lamelliassus chiangmaiensis

description: Lamelliassus chiangmaiensis sp. nov.
(Figs 5 A, B, 19A–G, 23B)
Male 7.0 mm long, 3.0 mm wide across humeral angles. Head and venter including legs unmarked; pronotum with median black spot on posterior margin; mesonotum dark orange brown anteriorly with four lobes extended posterad; scutellum black apically; forewing with base of clavus dark orange brown, corium with diffuse oblique brown stripe extended along bases of apical cells terminating in brown macula at wing apex and brown marginal area on appendix; hind wing hyaline (Fig. 5 A, B). Male subgenital plate approximately triangular with base weakly constricted, twice as long as maximum width (Fig. 19 C); connective stem somewhat broadened from base to apex, lateral margins of arms parallel (Fig. 19 D); style in lateral view with apophysis nearly straight, excavated preapically on dorsal surface, in ventral view with apex paddlelike (Fig. 19 B, G); aedeagus with posterolateral flange finely serrate preapically (Fig. 19 F, G).
Material examined. Holotype ♂ THAILAND: Chiang Mai, Doi Chiang Dao WS Nature trail 19º24.278'N 98º55.311'E 491m, Malaise trap 7–14.x.2007, Songkran & Apichart leg. T3175 [QSBG].
Note. The species name refers to the type locality, Chaing Mai Province, Thailand.
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on page 30, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
Magnetic Resonance Imaging of the Axial Skeleton in Patients With Spondyloarthritis: Distribution Pattern of Inflammatory and Structural Lesions
Creators: name: Hoffstetter, Patrick
name: Al Suwaidi, Mohammed H.
name: Joist, Alexander
name: Benditz, Achim
name: Fleck, Martin
name: Stroszczynski, Christian
name: Dornia, Christian
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: Spondyloarthritis (SpA), magnetic resonance imaging (MRI), axial skeleton
subject: 610 Medizin

description: Purpose:
Spondyloarthritis is a chronic inflammatory disorder of the musculoskeletal system driven by systemic enthesitis and typically involving the axial skeleton, ie, the spine and the sacroiliac joints. The purpose of this study was to assess the distribution pattern of inflammatory and structural magnetic resonance imaging (MRI) findings in spondyloarthritis.

Methods:
Retrospective study of 193 patients with axial spondyloarthritis who received MRI of the spine and the sacroiliac joints. We quantitatively assessed inflammatory and structural lesions using established MRI-based scoring methods. The significance of the differences between gender, HLA-B27 status, and spine and sacroiliac involvement was determined.

Results:
In total, 174 patients (90.2%) showed a sacroiliac involvement and 120 patients (62.2%) a combined involvement of the sacroiliac joints and the spine. An isolated sacroiliac involvement was found in 54 patients (28.0%) and an isolated spine involvement in 19 patients (9.8%). The sacroiliac joint was significantly more involved in men than in women (P < .01), and men had significantly higher scores for structural lesions (P < .001). The subgroup of HLA-B27–positive patients showed a significantly higher percentage of sacroiliac involvement compared with HLA-B27–negative patients (P < .05).

Conclusions:
Spondyloarthritis is a systemic disorder predominantly involving the sacroiliac joints. However, the entire axial skeleton may be affected. In particular, HLA-B27–negative women show atypical manifestations without sacroiliac involvement. Magnetic resonance imaging in spondyloarthritis should cover the entire axial skeleton, ie, sacroiliac joints and the spine to meet the pathophysiology of this disorder and capture the true extent of inflammatory and structural lesions.
Low Tube Voltage Liver MDCT with Sinogram-Affirmed Iterative Reconstructions for the Detection of Hepatocellular Carcinoma
Creators: name: Pregler, Benedikt
name: Beyer, L. P.
name: Teufel, A.
name: Niessen, C.
name: Stroszczynski, C.
name: Brodoefel, H.
name: Wiggermann, P.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: ABDOMINAL COMPUTED-TOMOGRAPHY; FILTERED BACK-PROJECTION; RADIATION-DOSE REDUCTION; IMAGE QUALITY; MULTIDETECTOR CT; PHANTOM; ALGORITHM; SAFIRE; NOISE; ANGIOGRAPHY;
subject: 610 Medizin

description: Aim of this study was to compare low tube voltage computed tomography (80 kV) of the liver using iterative image reconstruction (SAFIRE) with standard computed tomography (120 kV) using filtered back-projection (FBP) for the detection of hepatocellular carcinoma (HCC). 46 patients (43 men) with 93 HCC confirmed by 3T MRI with Gd-EOB-DPTA, in inconclusive cases combined with contrast-enhanced ultrasound, underwent dual-energy CT. The raw data of the 80 kV tube was reconstructed using the iterative reconstruction algorithm SAFIRE with two strengths (I3 and I5). The virtual 120 kV image data set was reconstructed using FBP. The CT images were reviewed to determine the lesion-to-liver contrast (LLC), the lesion contrast-to-noise ratio (CNR) and the sensitivity. The LLC (57.1/54.3 [I3/I5] vs. 34.9 [FBP]; p <= 0.01), CNR (3.67/4.45 [I3/I5] vs. 2.48 [FBP]; p < 0.01) and sensitivity (91.4%/88.2% [I3/I5] vs. 72.0% [FBP]; p <= 0.01) were significantly higher in the low-voltage protocol using SAFIRE. Therefore, low tube voltage CT using SAFIRE results in an increased lesion-to-liver contrast as well as an improved lesion contrast-to-noise ratio compared to FBP at 120 kV which results in a higher sensitivity for the detection of HCC.
Schönfelder, Roland / Pannier, Traute: Ich muß die Wurzeln meiner Hoffnung finden
Creators: name: Hugoth, Matthias
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Moinodaphnia macleayi
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Moinidae
Moinodaphnia
Moinodaphnia macleayi

description: Moinodaphnia macleayi (King, 1853)
– (1) Capivari Creek, Cruz das Almas, 12°40’10”S 39°06’21”W, 1999, leg. Eduardo Mendes da Silva (EL02201). (2) Timeantube Pond, Praia do Forte, Mata de São João, 12°34’41”S 38°00’47”W, 12.vii.2002, coll. L.M.A. Elmoor-Loureiro (EL00112). (3) Marsh at BA-001 road, approximately 23 Km south from Ilhéus, 15°0’59”S 38°59’56”W, 26.i.2006, coll. L.M.A. Elmoor-Loureiro (EL01786). (4) Waterbody on the road between Mucuri and BR-101, km 20, 17.iii.1995,coll. P.S. Young, C.B. Castro, A.E. Migotto, R.J.J. Silva, and C.A. Echeverria (MNRJ20310). (5) Pond on road BR-030, about 16 km from BR-101 to Itacaré, 16.ii.1997, coll. P.S. Young and C.S. Serejo (MNRJ15465, EL00608). (6) Marsh near Praia da Concha, Itacaré, 17.ii.1997, coll. P.S. Young and C.S. Serejo (MNRJ20347). (7) Marsh near Cairu, 20.ii.1997, coll. P.S. Young and C.S. Serejo (MNRJ20290, EL00607).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 19, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Bosmina (Bosmina) freyi De Melo and Hebert 1994
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Bosminidae
Bosmina
Bosmina freyi

description: Bosmina (Bosmina) freyi De Melo and Hebert,1994.
Pond on BA-697 road, near Nova Viçosa, 17°57’35”S 39°33’22”W, 22.i.1991, coll. L.M.A. Elmoor-Loureiro (EL03232, EL3238).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 19, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Femur First navigation can reduce impingement severity compared to traditional free hand total hip arthroplasty
Creators: name: Palit, Arnab
name: Williams, Mark A.
name: Turley, Glen A.
name: Renkawitz, Tobias
name: Weber, Markus
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: RANDOMIZED CONTROLLED-TRIAL; HEAD-SIZE; DISLOCATION; REPLACEMENT; POSITION; RANGE; THR;
subject: 610 Medizin

description: Impingement is a major source of dislocation and aseptic loosening in total hip arthroplasty (THA). We compared impingement free range of motion (ROM) using a novel computer navigated femur first approach to conventional THA. In addition, impingement between genders was also explored. In a retrospective analysis of 121 THA patients, subject-specific post-operative ROM was simulated using post-operative 3D-CT data, and compared with the benchmark ROM, essential for activities of daily living. Three parameters were defined to express both implant-to-implant (ITI) and bone-to-bone (BTB) impingement - coverage percentage, third angle, and impingement severity. Although coverage percentage was similar between the navigated and conventional group for both ITI (p = 0.69) and BTB (p = 0.82) impingement, third angle was significantly reduced in the navigation group for both ITI (p = 0.02) and BTB (p = 0.05) impingement. Impingement severity for both ITI (p = 0.01) and BTB (p = 0.05) was significantly decreased in the navigation group compared to the conventional. Impingement severity in men was considerably higher compared to women for both ITI (p = 0.002) and BTB (p = 0.02). Navigation guided femur first THA is able to improve alignment of ROM axis, and consequently, to reduce impingement in THA. Men seem to be more prone to impingement than women.
Bimetallic catalysts for upgrading of biomass to fuels and chemicals
Creators: name: Martin Alonso, David
name: Wettstein, Sthephanie
name: Dumesic, James
Publisher: name: Royal Society of Chemistry / Zenodo
Year: 2012

description: Research interest in biomass conversion to fuels and chemicals has increased significantly in the last decade as the necessity for a renewable source of carbon has become more evident. Accordingly, many different reactions and processes to convert biomass into high-value products and fuels have been proposed in the literature. Special attention has been given to the conversion of lignocellulosic biomass, which does not compete with food sources and is widely available as a low cost feedstock. In this review, we start with a brief introduction on lignocellulose and the different chemical structures of its components: cellulose, hemicellulose, and lignin. These three components allow for the production of different chemicals after fractionation. After a brief overview of the main reactions involved in biomass conversion, we focus on those where bimetallic catalysts are playing an important role. Although the reactions are similar for cellulose and hemicellulose, which contain C6 and C5 sugars, respectively, different products are obtained, and therefore, they have been reviewed separately. The third major fraction of lignocellulose that we address is lignin, which has significant challenges to overcome, as its structure makes catalytic processing more challenging. Bimetallic catalysts offer the possibility of enabling lignocellulosic processing to become a larger part of the biofuels and renewable chemical industry. This review summarizes recent results published in the literature for biomass upgrading reactions using bimetallic catalysts.
Bosmina (Liederobosmina) hagmanni Stingelin 1904
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Bosminidae
Bosmina
Bosmina hagmanni

description: Bosmina (Liederobosmina) hagmanni Stingelin,1904.
Pond on BA-697 road, near Nova Viçosa, 17°57’35”S 39°33’22”W, 22.i.1991, coll. L.M.A. Elmoor-Loureiro (EL3237).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 19, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Trainee Surgeons Affect Operative Time but not Outcome in Minimally Invasive Total Hip Arthroplasty
Creators: name: Weber, Markus
name: Benditz, Achim
name: Woerner, Michael
name: Weber, Daniela
name: Grifka, Joachim
name: Renkawitz, Tobias
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: JOINT REPLACEMENT SURGERY; TOTAL KNEE ARTHROPLASTY; RESIDENT INVOLVEMENT; OSTEOARTHRITIS; WOMAC; RESPONSIVENESS; COMPLICATION; PREDICTORS; EXPERIENCE; QUALITY;
subject: 610 Medizin

description: Training of young surgeons in total hip arthroplasty (THA) is crucial, but might affect operative time and outcome especially in minimally invasive (MIS) THA. We asked whether the learning curve of orthopaedic residents trained on MIS THA has an impact on (1) operative time (2) complication rates and (3) early postoperative outcome. In a retrospective analysis of over 1000 MIS THAs from our institutional joint registry, operative time, complication rates, patient reported outcome measures (Western Ontario and McMaster Universities Arthritis Index [WOMAC] and Euro-Qol 5D-5L [EQ-5D]) within the first year and responder rates for positive outcome as defined by the Outcome Measures in Rheumatology and Osteoarthritis Research Society International consensus responder (OMERACT-OARSI) criteria were compared between trainee and senior surgeons. Mean operative time was nine minutes longer for trainees compared to senior surgeons (78.1 +/- 25.4 min versus 69.3 +/- 23.8 min, p < 0.001). Dislocation (p = 0.21), intraoperative fracture (p = 0.84) and infection rates (p = 0.58) were comparably low in both groups. Both trainee and senior THAs showed excellent improvement of EQ-5D (0.34 +/- 0.26 versus 0.32 +/- 0.23, p = 0.40) and WOMAC (45.9 +/- 22.1 versus 44.9 +/- 20.0, p = 0.51) within the first year after surgery without clinical relevant differences. Similarly, responder rates for positive outcome were comparable between trainees with 92.9% and senior surgeons with 95.2% (p = 0.17). MIS THA seems to be a safe procedure during the learning curve of young orthopaedic specialists, but requires higher operative time.
title: Lettre n°1224 de Paul d'Estournelles de Constant à Nicholas Murray Butler (23 décembre 1922)
title: Letter number 1224 from Paul d'Estournelles de Constant to Nicholas Murray Butler (December 23, 1922)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Decoding Math Realms
Creators: name: M. Vasuki, Mbonigaba Celestin, A. Dinesh Kumar
Publisher: name: Zenodo
Year: 2025

description: Mathematics is the language of the universe, a timeless discipline that transcends cultural and temporal boundaries to unveil the intrinsic order of existence. It is both a tool and a philosophy, empowering humanity to decode the oursteries of the cosmos and craft solutions to some of the most complex challenges we face. Decoding Math Realms is a celebration of this profound truth, offering readers a journey into the heart of mathematics and its transformative power.

This book endeavors to bridge the often-daunting gap between abstract mathematical theories and their practical applications. By weaving together engaging examples, thought-provoking case studies, and contemporary insights, it demonstrates how mathematics influences a diverse range of fields. From unraveling the patterns of biological ecosystems and unlocking the potential of artificial intelligence to guiding urban planners in designing sustainable cities, mathematics is an ever-present force shaping our reality.

Through the pages of this book, readers will explore the elegance of geometry, the power of algebra, and the predictive strength of statistics. They will delve into the realms where mathematics meets cutting-edge technology-quantum computing, machine learning, and data science-illuminating how mathematical principles serve as the foundation for groundbreaking innovations. Moreover, the book sheds light on the pivotal role of mathematics in addressing critical global challenges, such as climate change, resource management, and healthcare advancements.

Whether you are a student seeking clarity, an educator searching for inspiration, or a professional aiming to apply mathematical tools in your field, Decoding Math Realms invites you to view mathematics not merely as an academic subject but as a way of thinking-a lens through which to perceive and navigate the world’s beauty and complexity. Each chapter builds on this perspective, fostering an appreciation for the interconnectedness of mathematical disciplines and their universal applicability.

In a world increasingly driven by data, algorithms, and technological advancements, understanding the role of mathematics has never been more essential. This book aspires to inspire curiosity, deepen understanding, and ignite a lifelong passion for exploring mathematical concepts. It is a tribute to the enduring relevance of mathematics and its capacity to empower individuals to question, discover, and innovate.

As you embark on this intellectual journey, prepare to uncover the connections between numbers, shapes, and patterns, and their profound implications in our lives. Whether deciphering the intricate patterns of DNA, simulating economic models, or navigating the complexities of quantum mechanics, mathematics is the key that unlocks the doors of possibility. Our hope is that this book will serve not only as an educational resource but also as a source of inspiration for all who seek to decode the mathematical realms that underpin our world.
title: The mere presence of a cell phone and academic ability
Creators: name: Boila, Vanessa C.
Publisher: name: Mount Royal University
publisherIdentifier: https://ror.org/04evsam41
publisherIdentifierScheme: ROR
Year: 2019
Subjects: Mere presence
Cell phones
Academic ability
Achievement
Library award winner

description: Prior research has suggested that cell-phone use in the classroom and during learningrelated tasks is detrimental to academic performance. Recently, the mere presence of a cell phone has been found to negatively affect relationships and to impair performance on learning and cognitive tasks. The present study explored whether the presence of a cell phone hinders performance on tests that measure pre-existing academic ability. In total, the study evaluated 45 participants who were enrolled in an introductory psychology course at Mount Royal University or who were members of the general public. Three subtests from the Wide Range Achievement Test (WRAT-4) were completed: spelling, sentence comprehension, and mathematics. During testing, half of the participants had their cell phones present and the other half did not. Statistical analyses revealed that when a cell phone belonging to a participant was merely present, there was no statistically significant difference in the demonstration of pre-existing skills on the sentence comprehension (p = .52), spelling (p = .07), and mathematics subtest (p = .11) compared to when a cell phone was removed. Unexpectedly, a non-significant trend was observed in the opposite direction; that is, the cell-phone-present group outperformed the cell-phone-absent group on all of the subtests.
Bosmina (Liederobosmina) tubicen Brehm 1953
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Bosminidae
Bosmina
Bosmina tubicen

description: Bosmina (Liederobosmina) tubicen Brehm,1953.
(1) Vasconcelos Reservoir, Cruz das Almas, 12°38’24”S 39°04’25”W, 23.ix.1999, leg. Eduardo Mendes da Silva (EL02202). (2) Abaeté Pond, Salvador, 12°56’44”S 38°21’27”W, 01.viii.1981, coll. Janet W. Reid (EL02222).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 19, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
APPLIED EPIDEMIOLOGY IN THE AUSTRALIAN COVID-19 PANDEMIC
Creators: name: Joo, Zoe
Publisher: name: The Australian National University
Year: 2024

description: The National Centre for Immunisation Research and Surveillance (NCIRS) plays a pivotal role in collaborative research in the policy and practice of vaccine preventable diseases at the local, national, and international levels. From February 2021 to December 2022, I undertook a field placement at NCIRS, in the Surveillance, Coverage, Evaluation and Social Sciences unit. This thesis contains details of my projects during the 22-month field placement. My projects include an evaluation of four surveillance systems on COVID-19 severity data in Australia, an investigation of a norovirus outbreak at a social event in Sydney Olympic Park, an analysis of COVID-19 notifications data in Australia from January 2020 to November 2021, and an analysis of an association between invasive meningococcal disease and socio-economic status in Australia. This thesis also describes other public health experiences during my placement. These experiences include my role as a contact tracer during the Delta outbreak at the Western Sydney Public Health Unit, my role in investigating the transmission of SARS-CoV-2 in educational settings in New South Wales and co-facilitating a pre-conference workshop at the Training Programs in Epidemiology and Public Health Interventions Network (TEPHINET) conference. Collectively, these projects and experiences fulfil the competencies of the Master of Philosophy in Applied Epidemiology program at the Australian National University.
Ilyocryptus sarsi Stingelin 1913
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Ilyocryptidae
Ilyocryptus
Ilyocryptus sarsi

description: Ilyocryptus sarsi Stingelin, 1913.
(1) Fish River, Itagibá, 14°11’–14°12’S 39°39’–39°42’W, x.2008 – vii.2009, coll. Sheila Bonfim de Jesus (SBJ). (2) Reservoir in Santa Rita Stream, Itagibá, 14°11’14”S 39°42’27”W, x.2008 – vii.2009, coll. Sheila Bonfim de Jesus (SBJ).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 20, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Nübold, Elmar: Entstehung und Bewertung der neuen Perikopenordnung des Röm. Ritu für die Meßfeier an Sonn- und Festtagen
Creators: name: Schmitz, Josef
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Siamiassus constanti Dai, Dietrich & Zhang, 2015, sp. nov.
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Siamiassus
Siamiassus constanti

description: Siamiassus constanti sp. nov.
(Figs 5 C, D, 20A–D, 23A)
Male 8.4 mm long, 3.9 mm wide across humeral angles. Color dull olive green; forewing densely marked with small black spots in basal 2/3 and along veins near apex; front and middle femur black in distal half, front tibia dark brown (Fig. 5 C, D). Structural features as described for genus (Fig. 20 A–D).
Type material. Holotype ♂ THAILAND: Loei, Na-Haeo (edge pond) 17.v.2003, J. Constant & K. Smets, light trap [RISB].
Notes. This species is named in honor of Dr. Jerome Constant, Auchenorrhyncha expert at the Royal Belgian Institute of Natural Sciences, Brussels, collector of the holotype and host to CHD during a recent visit to Brussels.
Siniassus nom. nov. (replacement for Sinojassus Dai, Zhang, Zhang & Dietrich 2010, nec Sinojassus Zhang 1985) Notes. The genus was described by Dai et al. (2010) and given the name Sinojassus, but this name is a junior homonym of an older fossil genus, Sinojassus Zhang (1985) and, therefore, must be given a new replacement name. Siniassus resembles Trocnadella in overall body form and the absence of a separately articulated connective in the male genitalia, but may be distinguished by the presence of numerous dark spots on the dorsum and the elongate style apodeme.
Included species:
Siniassus aspinus (Dai, Zhang & Zhang), comb. n. (Fig. 4 A, B) Sinojassus aspinus Dai, Zhang & Zhang 2010 in Dai, Zhang, Zhang & Dietrich (2010)
Siniassus compressus (Dai, Zhang & Zhang), comb. n. (Fig. 4 C, D)
Sinojassus compressus Dai, Zhang & Zhang 2010 in Dai, Zhang, Zhang & Dietrich (2010)
Siniassus loberus (Dai, Zhang & Zhang 2010), comb. n. (Fig. 4 E, F)
Sinojassus loberus Dai, Zhang & Zhang 2010 in Dai, Zhang, Zhang & Dietrich (2010) Material examined. CHINA: Yunnan, Xishuanbanna, Mengla 1050–1080 m, 20 May 1958, 1 male; Yunnan, Menghai, 1250 m, 27 Feb. 1957 [IOZB].
Siniassus webbi (Dai & Dietrich 2010), comb. n. (Fig. 4 G, H)
Sinojassus webbi Dai & Dietrich, in Dai, Zhang, Zhang & Dietrich (2010)
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on pages 32-34, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
Göpfert, Peter / Kauffmann, Egon: Kinder machen sich Gedanken
Creators: name: Grunert, E.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Ringel, Erwin / Kirchmayr, Alfred: Religionsverlust durch religiöse Erziehung
Creators: name: Ditzer, K.H.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Reviewing the Effectiveness of Music Interventions in Treating Depression
Creators: name: Leubner, Daniel
name: Hinterberger, Thilo
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: depression, music therapy, meta-analysis, neuropsychology, psychosomatic medicine, neurophysiology, anxiety, stress
subject: 610 Medizin

description: Depression is a very common mood disorder, resulting in a loss of social function, reduced quality of life and increased mortality. Music interventions have been shown to be a potential alternative for depression therapy but the number of up-to-date research literature is quite limited. We present a review of original research trials which utilize music or music therapy as intervention to treat participants with depressive symptoms. Our goal was to differentiate the impact of certain therapeutic uses of music used in the various experiments. Randomized controlled study designs were preferred but also longitudinal studies were chosen to be included. 28 studies with a total number of 1,810 participants met our inclusion criteria and were finally selected. We distinguished between passive listening to music (record from a CD or live music) (79%), and active singing, playing, or improvising with instruments (46%). Within certain boundaries of variance an analysis of similar studies was attempted. Critical parameters were for example length of trial, number of sessions, participants' age, kind of music, active or passive participation and single- or group setting. In 26 studies, a statistically significant reduction in depression levels was found over time in the experimental (music intervention) group compared to a control (n = 25) or comparison group (n = 2). In particular, elderly participants showed impressive improvements when they listened to music or participated in music therapy projects. Researchers used group settings more often than individual sessions and our results indicated a slightly better outcome for those cases. Additional questionnaires about participants confidence, self-esteem or motivation, confirmed further improvements after music treatment. Consequently, the present review offers an extensive set of comparable data, observations about the range of treatment options these papers addressed, and thus might represent a valuable aid for future projects for the use of music-based interventions to improve symptoms of depression.
Hyperosmotic stress enhances cytotoxicity of SMAC mimetics
Creators: name: Bittner, Sebastian
name: Knoll, Gertrud
name: Ehrenschwender, Martin
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: TUMOR-NECROSIS-FACTOR; ALPHA-DEPENDENT APOPTOSIS; KAPPA-B ACTIVATION; TNF-ALPHA; INDUCED NECROPTOSIS; BINDING PROTEIN; CELL-DEATH; L929 CELLS; CANCER; CIAP1;
subject: 610 Medizin

description: Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical trials. In cancer cells, SMAC mimetic (SM)-mediated IAP depletion induces tumor necrosis factor (TNF) secretion and simultaneously sensitizes for TNF-induced cell death. However, tumor cells lacking SM-induced autocrine TNF release survive and thus limit therapeutic efficacy. Here, we show that hyperosmotic stress boosts SM cytotoxicity in human and murine cells through hypertonicity-induced upregulation of TNF with subsequent induction of apoptosis and/or necroptosis. Hypertonicity allowed robust TNF-dependent killing in SM-treated human acute lymphoblastic leukemia cells, which under isotonic conditions resisted SM treatment due to poor SM-induced TNF secretion. Mechanistically, hypertonicity-triggered TNF release bypassed the dependency on SM-induced TNF production to execute SM cytotoxicity, effectively reducing the role of SM to TNF-sensitizing, but not necessarily TNF-inducing agents. Perspectively, these findings could extend the clinical application of SM.
Interaction between NFATc2 and the transcription factor Sp1 in pancreatic carcinoma cells PaTu 8988t
Creators: name: Malsy, Manuela
name: Graf, Bernhard
name: Almstedt, Katrin
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: ENDOTHELIAL GROWTH-FACTOR; DNA-BINDING ACTIVITY; ACTIVATED T-CELLS; NUCLEAR FACTOR; FACTOR FAMILY; C-MYC; CANCER; EXPRESSION; DIFFERENTIATION; PATHWAY; NFATc2; Sp1; Pancreatic carcinoma; Binding partner; Cancer
subject: 610 Medizin

description: Background: Nuclear factors of activated T-cells (NFATs) have been mainly characterized in the context of immune response regulation because, as transcription factors, they have the ability to induce gene transcription. NFAT proteins are found in several types of tumors, for instance, pancreatic carcinoma. The role of NFATs in carcinogenesis is regulating central genes in cell differentiation and cell growth. NFAT proteins are primarily located in cytoplasm and only transported to the cell nucleus after activation. Here, they interact with other transcription factors cooperating with NFAT proteins, thus influencing the selection and regulation of NFAT-controlled genes. To identify and characterize possible interaction partners of the transcription factor NFATc2 in pancreatic carcinoma cells PaTu 8988t. Methods: NFATc2 expression and the mode of action of Ionomycin in the pancreatic tumor cell lines PaTu 8988t were shown with Western blotting and immunofluorescence tests. Potential partner proteins were verified by means of immunoprecipitation and binding partners, their physical interactions with DNA pull-down assays, siRNA technologies, and GST pull-down assays. Functional evidence was complemented by reporter-promoter analyses. Results: NFATc2 and Sp1 are co-localized in cell nuclei and physically interact at the NFAT target sequence termed NFAT-responsive promotor construct. Sp1 increases the functional activity of its binding partner NFATc2. This interaction is facilitated by Ionomycin in the early stimulation phase (up to 60 min). Conclusions: Oncological therapy concepts are becoming more and more specific, aiming at the efficient modulation of specific signal and transcription pathways. The oncogenic transcription partner Sp1 is important for the transcriptional and functional activity of NFATc2 in pancreatic carcinoma. The binding partners interact in cells. Further studies are necessary to identify the underlying mechanisms and establish future therapeutic options for treating this aggressive type of tumor.
Annotations on campaign in Dacia (related to P.Lond inv. 2851)
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 21
description: Study, bibliographical and epigraphical references of Dacian geography and Roman campaigns in Dacia. - typewriten corrections by Davies on CLA III 214, receipt from the EPHS Trade unions. - annotations on papyrus, transcription, map of the lower Danube, Marichal's personal card. - annotations, bibliography and commentary on "decedunt" (coll. II). - letter from T.C Skeat. - typewriten and annotated commentary upon the papyrii, geographical annotations, bibliography.
description: Source: 4MAR_19_3.2-1-2
description: Relation: T. C. Skeat
description: Coverage: London
description: created: n. d., 10th April 1962
Kampik, Michael: Die Erschaffung des Kusses und andere Legenden von der Liebe
Creators: name: Hugoth, M.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation
Creators: name: Meyre, David
name: Winkler, Thomas W.
name: Justice, Anne E.
name: Cupples, L. Adrienne
name: Kronenberg, Florian
name: Kutalik, Zoltán
name: Heid, Iris M.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: BODY-MASS INDEX; ENVIRONMENT INTERACTION; QUANTITATIVE TRAITS; FAT DISTRIBUTION; ASSOCIATION; LOCI; SUSCEPTIBILITY; EPIDEMIOLOGY; EFFICIENT; VARIANTS;
subject: 610 Medizin

description: Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to identify between-strata differences in genetic effects. We evaluate type I error and power via simulations and analytical comparisons for different scenarios of strata designs and for different types of between-strata differences. For strata of equal size, we find that the genome-wide test for difference without any filtering is the best approach to detect stratum-specific genetic effects with opposite directions, while filtering for overall association followed by the difference test is best to identify effects that are predominant in one stratum. When there is no a priori hypothesis on the type of difference, a combination of both approaches can be recommended. Some approaches violate type I error control when conducted in the same data set. For strata of unequal size, the best approach depends on whether the genetic effect is predominant in the larger or in the smaller stratum. Based on real data from GIANT (>175 000 individuals), we exemplify the impact of the approaches on the detection of sex-differences for body fat distribution (identifying up to 10 loci). Our recommendations provide tangible guidelines for future GWAMAs that aim at identifying between-strata differences. A better understanding of such effects will help pinpoint the underlying mechanisms.
A Proposal for Updated Standards of Photographic Documentation in Aesthetic Medicine
Creators: name: Prantl, Lukas
name: Brandl, Dirk
name: Ceballos, Patricia
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: 610 Medizin

description: Summary: In 1998, DiBernardo et al. published a very helpful standardization of
comparative (before and after) photographic documentation. These standards prevail
to this day. Although most of them are useful for objective documentation of aesthetic
results, there are at least 3 reasons why an update is necessary at this time: First,
DiBernardo et al. focused on the prevalent standards of medical photography at that
time. From a modern perspective, these standards are antiquated and not always correct.
Second, silver-based analog photography has mutated into digital photography.
Digitalization offers virtually unlimited potential for image manipulation using a vast
array of digital Apps and tools including, but not limited to, image editing software
like Photoshop. Digitalization has given rise to new questions, particularly regarding
appropriate use of editing techniques to maximize or increase objectivity. Third, we
suggest changes to a very small number of their medical standards in the interest of
obtaining a better or more objective documentation of aesthetic results. This article
is structured into 3 sections and is intended as a new proposal for photographic and
medical standards for the documentation of aesthetic interventions:
1. The photographic standards.
2. The medical standards.
3. Description of editing tools which should be used to increase objectivity. (Plast
Reconstr Surg Glob Open 2017;5:e1389; doi: 10.1097/GOX.0000000000001389; Published
online 17 August 2017.)
Grimaldina freyi Neretina and Kotov 2017
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Macrothricidae
Grimaldina
Grimaldina freyi

description: Grimaldina freyi Neretina and Kotov, 2017.
(1) Pedra do Cavalo Reservoir, Governador Mangabeira, 12°56’59”S 38°20’25”W, 27.iii.2002, leg. Eduardo Mendes da Silva (EL00334). (2) Timeantube Pond, Praia do Forte, Mata de São João, 12°34’41”S 38°00’47”W, 12.vii.2002, coll. L.M.A. Elmoor-Loureiro (EL00335). (3) Pond at Pojuca, 12°24’31”S 38°20’40”W, 2019, coll. Rafael L. Macedo (NEL / UNIRIO).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 20, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828