cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rusa unicolor
Creators: name: Cook-Price, Dawn R.
name: Petko, Olga N.
name: Makchai, Sunchai
name: Artchawakom, Taksin
name: Suwanwaree, Pongthep
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Cervidae
Rusa
Rusa unicolor

description: Rusa unicolor (Kerr, 1792)
Fig. 8 Sambar Deer
Notes.
This species is nocturnal and herbivorous feeding on a variety of plants including trees, shrubs, and grasses found in the forested areas they have been observed (Suksawat et al. 2018). The sambar deer has been detected twelve times (Table 2) via camera trap in eight transects in national park forest and three different human-disturbed forest transects connected to national park forest; however, there was one opportunistic observation directly across the stream from the headquarters of the national park.
description: Published as part of Cook-Price, Dawn R., Petko, Olga N., Makchai, Sunchai, Artchawakom, Taksin & Suwanwaree, Pongthep, 2025, Mammal diversity survey of Ko Pha-ngan in Surat Thani Province, Thailand, pp. 77-102 in ZooKeys 1229 on pages 77-102, DOI: 10.3897/zookeys.1229.118127
Ergothioneine production with Aspergillus oryzae
Creators: name: Takusagawa, Shun
name: Satoh, Yasuharu
name: Ohtsu, Iwao
name: Dairi, Tohru
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: To establish a reliable and practical ergothioneine (ERG) supply, we employed fermentative ERG production using Aspergillus oryzae, a fungus used for food production. We heterologously overexpressed the egt-1 and -2 genes of Neurospora crassa in A. oryzae and succeeded in producing ERG (231.0 mg/kg of media, which was 20 times higher than the wild type). Abbreviations: ERG: ergothioneine; HER: hercynine; Cys-HER: hercynylcysteine-sulfoxide; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; l-His: l-histidine; l-Cys: l-cysteine; LC-ESI-MS: liquid chromatography-electrospray ionization-mass spectrometry
Mesonic Spectrum of Two Dimensional Supersymmetric Theories
Creators: name: Lunin, Oleg
name: Pinsky, Stephen
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a bound state problem for a family of supersymmetric gauge theories with fundamental matter. These theories can be obtained by a dimensional reduction of supersymmetric QCD from three dimensions to 1+1 and subsequent truncation of some of the fields. We find that the models without adjoint scalar converge to well-defined continuum limits and calculate the resulting spectra of these theories. We also find the critical value of coupling at which an additional massless state is observed. By contrast, the models containing adjoint scalars, seem to have a continuous mass spectrum in the limit of infinite volume.
description: 23 pages, 12 figures
Volume, Polar Volume and Euler Characteristic for Convex Functions
Creators: name: Mussnig, Fabian
Publisher: name: arXiv
Year: 2018
Subjects: subject: Metric Geometry (math.MG)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 26B25 (Primary) 46A40, 52A20, 52A41, 52B45 (Secondary)

description: Functional analogs of the Euler characteristic and volume together with a new analog of the polar volume are characterized as non-negative, continuous, $\operatorname{SL}(n)$ and translation invariant valuations on the space of finite, convex and coercive functions on ${\mathbb R}^n$.
Oral history interview with Leroy Street, 1981
Publisher: name: Columbia University
Year: 2020
Subjects: Authors
Artists
Drug addicts--United States
Heroin abuse--History--20th century.--United States
Drug addicts--Rehabilitation--United States
Methadone maintenance--History--20th century.--United States
Therapeutic communities
Crime--New York (State)

description: In this interview, Leroy Street discusses his autobiography, "I Was a Drug Addict." He reviews some details that are included in the book, such as his addiction to heroin from 1910 to 1923, his cycles of detox and relapse, his eventual turn to stealing to finance his heroin use, his stints in jail, and his wife, who he credits as his reason to stop using heroin. He also comments on the beginning of recreational heroin use in New York City in Greenwich Village, and how it spread across the nation. He discusses the process of writing his book with his collaborator David Loth, and his choice to publish it under a pseudonym. Street describes the New York City Narcotic Clinic, which he frequented for the year it was open from 1919 to 1920. He discusses not just the physical, but the psychological side of his personal heroin cravings. He discusses his opinions of methadone maintenance programs as well as therapeutic community models such as Phoenix House, Daytop, and Odyssey House. Street delves into his opinion of the most effective way to stay off drugs. He discusses his career as a commercial artist, including as an illustrator for Wanamaker catalogues, and an art instructor at Traphagen School
KHSO4 promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides
Creators: name: Zheng, Jiecheng
name: Gong, Feng
name: Wang, Wei
name: Wu, Yue
name: Zhao, Dezhang
name: Zhang, Tianyuan
name: Yang, WenWen
name: Gan, Zongjie
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Biological Sciences not elsewhere classified
Mental Health
Computational Biology

description: A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO4 promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO4 also makes this protocol more attractive.
The insight of in vitro and in silico studies on cholinesterase inhibitors from the roots of Cimicifuga dahurica (Turcz.) Maxim.
Creators: name: Kim, Jang Hoon
name: Nguyen Phuong Thao
name: Han, Yoo Kyong
name: Lee, Young Suk
name: Bui Thi Thuy Luyen
name: Oanh, Ha Van
name: Kim, Young Ho
name: Yang, Seo Young
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Cholinesterases (ChEs) are enzymes that break down neurotransmitters associated with cognitive function and memory. We isolated cinnamic acids (1 and 2), indolinones (3 and 4), and cycloartane triterpenoid derivatives (5–19) from the roots of Cimicifuga dahurica (Turcz.) Maxim. by chromatography. These compounds were evaluated for their inhibitory activity toward ChEs. Compound 1 was determined to have an IC50 value of 16.7 ± 1.9 μM, and to act as a competitive inhibitor of acetylcholinesterase (AChE). Compounds 3, 4 and 14 were found to be noncompetitive with IC50 values of 13.8 ± 1.5 and 6.5 ± 2.5 μM, and competitive with an IC50 value of 22.6 ± 0.4 μM, respectively, against butyrylcholinesterase (BuChE). Our molecular simulation suggested each key amino acid, Tyr337 of AChE and Asn228 of BuChE, which were corresponded with potential inhibitors 1, and 3 and 4, respectively. Compounds 1 and 4 were revealed to be promising compounds for inhibition of AChEs and BuChEs, respectively.
Recovery of 29-s Oscillations in HST/FOS Eclipse Observations of the Cataclysmic Variable UX Ursae Majoris
Creators: name: Knigge, C.
name: Drake, N.
name: Long, K. S.
name: Wade, R. A.
name: Horne, K.
name: Baptista, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: [abridged abstract] Low amplitude (~=0.5%) 29-s oscillations have been detected in HST/FOS eclipse observations of the nova-like cataclysmic variable UX UMa. These are the same dwarf nova-type oscillations that were originally discovered in this system by Warner & Nather in 1972. The oscillations are sinusoidal to within the small observational errors and undergo an approximately -360 degree phase shift during eclipses. Their amplitudes are highest at pre-eclipse orbital phases and exhibit a rather gradual eclipse whose shape is roughly similar to UX~UMa's overall light curve. Oscillation spectra derived from pre-eclipse data segments are extremely blue, whereas mid-eclipse oscillation spectra are much redder. We suggest that the ultimate source of the oscillations is a hot, compact region near disk center, but that a significant fraction of the observed, modulated flux is due to reprocessing of the light emitted by this source in the accretion disk atmosphere. The compact source is occulted at orbital phases near mid-eclipse, leaving only part of the more extended reprocessing region(s) to produce the weak oscillations that persist even at conjunction. The highly sinusoidal oscillation pulse shape does not permit the identification of the compact component in this model with emission produced by a rotating disturbance in the inner disk or in an equatorial boundary layer, and a standard intermediate polar model can also be ruled out. A model invoking magnetically controlled accretion onto differentially rotating WD surface layers may be viable, but needs more theoretical work.
description: 28 pages, including 9 figures; to appear in the ApJ (Vol. 499)
Sus scrofa
Creators: name: Cook-Price, Dawn R.
name: Petko, Olga N.
name: Makchai, Sunchai
name: Artchawakom, Taksin
name: Suwanwaree, Pongthep
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Suidae
Sus
Sus scrofa

description: Sus scrofa (Linnaeus, 1758)
Fig. 8 Wild boar
Notes.
This species was observed thirteen times on camera traps (Table 2). It was observed in two national park forest transects and one human-disturbed forest transect (Fig. 6). The first observation of three piglets were sighted with an adult female, presumably the mother (enlarged teats) and a few months later in a different camera trap area (further north), an adult and larger sized piglets were observed. These wild boars can inflict a large amount of damage to plants in an ecosystem (Ickes 2001).
description: Published as part of Cook-Price, Dawn R., Petko, Olga N., Makchai, Sunchai, Artchawakom, Taksin & Suwanwaree, Pongthep, 2025, Mammal diversity survey of Ko Pha-ngan in Surat Thani Province, Thailand, pp. 77-102 in ZooKeys 1229 on pages 77-102, DOI: 10.3897/zookeys.1229.118127
Oral history interview with Leslie Andrew Miller, 1966
Publisher: name: Columbia University
Year: 2020
Subjects: Executives
Conservation of natural resources
National parks and reserves--United States

description: Experience in politics; early contact with Jackson Hole: purchase of land, forest-park feud, Congressional delegation, monument proclamation, local press; member of Board of Jackson Hole Preserve. Impressions of the Rockefeller family
Modelling of integrated-light spectra from the optical to the near-infrared: the globular cluster G280 in M31
Creators: name: Larsen, S. S.
name: Pugliese, G.
name: Brodie, J. P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In previous papers, we introduced our method for measuring chemical abundances from integrated-light spectra of globular clusters and applied it to a variety of extragalactic star clusters. Here we extend our analysis technique to the infrared. We simultaneously analyse an optical spectrum of the massive globular cluster G280 in M31, obtained with the HIRES spectrograph on the Keck I telescope, and an H-band spectrum obtained with NIRSPEC on Keck II. We discuss the sensitivity of our results to various modifications of the input assumptions, such as different line lists and isochrones and the possible presence of a metallicity spread in G280. When using the most recent version of the Kurucz line list, we measure iron abundances of [Fe/H]=-0.68+/-0.02 from the optical spectrum and [Fe/H]=-0.60+/-0.07 from the infrared spectrum. These values agree well with previous spectroscopic determinations of the metallicity of G280. While the small difference between the optical and infrared measurements is insignificant given the uncertainties, it is also consistent with a metallicity spread similar to that observed in massive GCs such as Omega Cen and G1, and also hinted at by the colour-magnitude diagram of G280. The optical and infrared spectra both indicate an alpha-enhancement of about 0.3-0.4 dex relative to solar-scaled abundances, as typically also observed in Milky Way GCs. It appears that our integrated-light analysis technique also performs well in the H-band. However, complications due to the presence of molecular bands and telluric contamination are more severe in the infrared, and accurate modelling of the coolest giants is more critical.
description: Accepted for publication in Astronomy & Astrophysics
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00143
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00143, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00143, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Non-classical correlations in a two-mode optomechanical system
Creators: name: Qars, J. El
name: Daoud, M.
name: Laamara, R. Ahl
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The pairwise quantum correlations in a tripartite optomechanical system comprising a mechanical mode and two optical modes are analyzed. The Simon criterion is used as a witness of the separability. Whereas, the Gaussian discord is employed to capture the quantumness of correlations. Both entanglement and Gaussian discord are evaluated as functions of the parameters characterizing the environment and the system (temperature, squeezing and optomechanical coupling). We work in the resolved-sideband regime. We show that it is possible to reach simultaneous three bipartite entanglements via the quantum correlations transfer from the squeezed light to the system. While, even without squeezed light, the quantumness of correlations can be captured simultaneously between the three modes for a very wide range of parameters. Specifically, we find that the two optical modes exhibit more quantum correlations in comparison with the entangled mechanical-optical modes. Finally, unlike the two hybrid subsystems, the purely optical one seems more resilient against the environmental destructive effects.
Oral history interview with Leroy W. Leiter 1974
Publisher: name: Columbia University
Year: 2019
Subjects: Cannery workers
Manufacturing processes
Labor unions--Officials and employees
Quality control

description: Van Wert Container Company from 1937: loading paper, running machines, crewleader, material handling, 1965 accident; various drums, stitching, glues; changes in manufacturing and staff, Continental Can takeover, quality control, union, women workers, benefits; impressions of Hans Eggerss.
Worldsheet and Spacetime Properties of p-p' System with B Field and Noncommutative Geometry
Creators: name: Chen, B.
name: Itoyama, H.
name: Matsuo, T.
name: Murakami, K.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study worldsheet and spacetime properties of the p-p' (p < p') open string system with constant B_{ij} field viewed from the Dp' brane. The description of this system in terms of the CFT with spin and twist fields leads us to consider the renormal ordering procedure from the SL(2,R) invariant vacuum to the oscillator vacuum. We compute the attendant two distinct superspace two-point functions as well as their difference (the subtracted two-point function). These bring us an integral (Koba-Nielsen) representation for the multiparticle tree scattering amplitudes consisting of N-2 vectors and two tachyons. We evaluate them explicitly for the N=3,4 cases. Several novel features are observed which include a momentum dependent multiplicative factor to each external vector leg and the emergence of a symplectic tensor multiplying the polarization vectors. In the zero slope limit, the principal parts of the amplitudes translate into a noncommutative field theory in p'+1 dimensions in which a scalar field decaying exponentially in (p'-p) dimensions and a noncommutative U(1) gauge field interact via the minimal coupling and a new interaction. A large number of nearly massless states noted before are shown to propagate in the t-channel.
description: 41 pages, 4 figures, Latex; revised version, typos corrected, comment on spacetime picture and eq. (5.8) improved
Synthetic strategies and anticancer evaluation for the novel 3-(6-heteroaryltriazolo[3,4-b][1,3,4]thiadiazol-3-yl)chromeno [2,3-b]pyridines
Creators: name: Alshaye, Najla A.
name: Ibrahim, Magdy A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The novel chromonyltriazolo[3,4-b][1,3,4]thiadiazole derivative 5 was efficiently synthesized and utilized as key intermediate for construction of a diversity of heterocyclic rings; through reactions with binucleophilic reagents. Treating electron deficient substrate 5 with hydrazine hydrate, phenylhydrazine and hydroxylamine furnished pyrazolyl/isoxazolyltriazolo[3,4-b][1,3,4]thiadiazoles 6-8. Also, reacting substrate 5 with guanidine, cyanoguanidine and thiourea provided pyrimidinyltriazolo[3,4-b][1,3,4]thiadiazoles 9-11. Reaction of substrate 5 with ethylenediamine and o-phenylenediamine afforded diazepine derivatives 12 and 13. Reaction of substrate 5 with malononitrile, ethyl cyanoacetate and cyanoacetamide afforded pyrans 14, 15 and pyridine 16 linked triazolo[3,4-b][1,3,4]thiadiazolyl chromeno[2,3-b]pyridines. The anticancer efficiency of the current compounds presented diverse inhibitory action against certain cancer cell lines. On the basis of analytical and spectral findings, the structures of the synthesized products were confirmed.
Thermodynamics and Glassy Phase Transition of Regular Black Holes
Creators: name: Javed, Wajiha
name: Yousaf, Z.
name: Akhtar, Zunaira
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The present paper is aimed to study thermodynamical properties of phase transition for regular charged black holes. In this context, we have considered two different forms of black hole metrics supplemented with exponential and logistic distribution functions and investigated the recent expansion of phase transition through grand canonical ensemble. After exploring the corresponding Ehrenfest's equation, we found the second order background of phase transition at critical points. In order to check the critical behavior of regular black holes, we have evaluated some corresponding explicit relations for the critical temperature, pressure and volume and draw certain graphs with constant values of Smarr's mass. We found that for the BH metric with exponential configuration function, the phase transition curves are divergent near the critical points, while glassy phase transition has been observed for the Ayón-Beato-García-Bronnikov BH in $n=5$ dimensions.
description: 26 pages, 11 figures
The Casimir-Polder potential in the presence of a Fock state
Creators: name: Haug, Theodor
name: Bennett, Robert
name: Buhmann, Stefan Yoshi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Atom-surface forces using excited states have a host of compelling applications, including repulsive and lateral forces. However, such states can be fragile and difficult to prepare. Here we report an explicit normal-mode based calculation of the Casimir-Polder potential between a ground-state atom and a non-dispersive surface in the presence of an external quantised field. The potential we derive shares some features with that of excited-state Casimir-Polder forces even though we consider a ground-state atom. Our work provides a physically transparent and intuitive picture of driven Casimir-Polder potentials, as well as expanding on previous investigations by providing analytic results that fully include retardation, as well as being applicable for any choice of mutual alignment of the atom's dipole moment, the external field, and the surface normal.
Hybrid devices for lab-chip chromatography and droplet-based microfluidics
Creators: name: Kim, Jin-Young
Publisher: name: Imperial College London
Year: 2012

description: Recent years have seen considerable interest in the use of microfabricated systems in chemical and biological due to their significant advantages in terms of speed, analytical throughput, yield, unit cost, footprint, reagent requirements and control. Inevitably this has led to a growing interest in transferring chromatographic methods to planar chip formats since techniques using high performance LC play such a prominent role in modern bioanalysis. In addition, the manipulation of multiphase (or segmented) flows within microfluidic channels has been recently investigated as a promising approach for large-scale experimentation in biology and chemistry. Importantly, flow segmentation allows for the compartmentalisation of reagent volumes ranging from a few femtolitres to hundreds of nanolitres within a continuous and immiscible fluid, the production of monodisperse droplets at high frequencies, the accurate control of droplet contents and the ability to perform kinetic analysis with high precision. Accordingly the integration of droplet-based microfluidics with HPLC has the potential to dramatically reduce dispersion and minimise dead volume effects by using droplets to collect fractions of the column effluent. This basic progress preserves the chemical identity of each fraction allowing further analysis downstream. In this work, microfluidic devices were fabricated using thermoset polyester (TPE) to operate under high pressure which is required for LC separation and high frequency droplet generation. The optical characteristics of the fabricated devices were assessed for feasibility of optical detections for droplets. Substrate resistance to pressure also was investigated for droplet generation with high frequency. Lastly, droplets were generated under various conditions by adjusting flow-rates and the oil viscosity. Secondly LC separation columns were formed in TPE channels using two different column materials: particulate and polymer monolithic columns. The packed channels were investigated by SEM. In addition, permeability was calculated from back25 pressures measured as a function of flow-rates and compared with columns. Neurotransmitters were separated by the columns to estimate performance. Thirdly, the both operations, LC separation and droplet-based microfluidics, were combined in a single planar format. Sequential operations of separation, compartmentalisation and concentration gradient generation were integrated on a single chip and characterised using confocal laser-induced fluorescence detection. Finally, a preliminary investigation is reported into the possibility of the indirect electrochemical detection as a universal detection that can monitor electrochemically detectable samples as well as non- or less-electroactive bio samples. Amino acids were separated by a commercial RPHPLC column and detected indirectly.
Age-related differences in multimodal recipient design: younger, but not older adults, adapt speech and co-speech gestures to common ground
Creators: name: Schubotz, Louise
name: Aslı Özyürek
name: Holler, Judith
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Speakers can adapt their speech and co-speech gestures based on knowledge shared with an addressee (common ground-based recipient design). Here, we investigate whether these adaptations are modulated by the speaker’s age and cognitive abilities. Younger and older participants narrated six short comic stories to a same-aged addressee. Half of each story was known to both participants, the other half only to the speaker. The two age groups did not differ in terms of the number of words and narrative events mentioned per narration, or in terms of gesture frequency, gesture rate, or percentage of events expressed multimodally. However, only the younger participants reduced the amount of verbal and gestural information when narrating mutually known as opposed to novel story content. Age-related differences in cognitive abilities did not predict these differences in common ground-based recipient design. The older participants’ communicative behaviour may therefore also reflect differences in social or pragmatic goals.
Synthesis of 2-aryl quinoxaline derivatives and their in silico investigation for breast cancer medication
Creators: name: Wadhwani, Barkha Darra
name: Mali, Deepak
name: Agarwal, Lokesh Kumar
name: Kumawat, Pooja
name: Vyas, Pooja
name: Nair, Rashmy
name: Kumar, Tarun
name: Khandelwal, Poonam
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The main objective of the present work is to synthesize and identify the potential breast cancer medication of 2-aryl quinoxaline ­derivatives via in silico investigations. Synthesis of 2-aryl quinoxaline derivatives have been achieved via the reaction of 3-aroylmethylene-2H-indol-2-ones 1 with various 1,2-diamines. Good yields were obtained at 60 °C in methanol by using graphene oxide (GO) as catalyst, however, the regio selectivity in case of unsymmetrically substituted diamines were low to moderated. This is the first report of the oxidative cleavage of C = C bond during the course of the reaction. Molecular docking study of these synthesized compounds were employed to calculate the binding affinity with human epidermal growth factor receptor 2 (HER2). 6-Bromo-3-phenylpyrido[2,3-b]pyrazine 3k showed highest binding energy of −7.70 kcal/mol depicting the potential inhibitor of HER2 receptor protein. However, this study needs to be supported by in vitro and in vivo studies.
scRNAseq analysis code: Fernandez Garcia-Agudo, Steixner-Kumar, Curto et al. (2021) - Cell reports
Creators: name: Steixner-Kumar, Agnes
Publisher: name: Zenodo
Year: 2021
Subjects: Hypoxia, recombinant human EPO, neurogenesis, neurodifferentiation, CSF1R, IL-34, PLX5622, microglia activity, apoptosis, proliferation

description: In adult cornu ammonis hippocampi, erythropoietin (EPO) expression drives differentiation of new neurons, independent of DNA synthesis, and increases dendritic spine density. This substantial brain hardware upgrade is part of a regulatory circle: During motor-cognitive challenge, neurons experience ‘functional’ hypoxia, triggering neuronal EPO production, which in turn promotes improved performance (EPO brain doping). Here, we show an unexpected involvement of resident microglia. During EPO upregulation and stimulated neurodifferentiation, either by functional or inspiratory hypoxia, microglia numbers decrease. Treating mice with recombinant human (rh)EPO or exposure to hypoxia recapitulates these changes and reveals involvement of neuronally expressed IL-34 and microglial CSF1R. Surprisingly, EPO affects microglia in phases, initially by inducing apoptosis, later by reducing proliferation, and overall dampens microglia activity and metabolism, as verified by selective genetic targeting of either microglial or pyramidal neuronal EPO receptor. We suggest that during accelerating neuronal differentiation, EPO acts as regulator of the CSF1R-dependent microglia.
Endothelial colony-­‐forming cells and transforming growth factor-­‐β superfamily signalling in idiopathic pulmonary arterial hypertension
Creators: name: Lao, Ka Hou
Publisher: name: Imperial College London
Year: 2013

description: Circulating endothelial progenitor cells may be important in the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) and give rise to endothelial colony-­‐forming cells (ECFCs) in culture. These cells represent an accessible surrogate population to investigate endothelial dysfunction in IPAH. Peripheral blood mononuclear cells were cultured from healthy volunteers (n=25, 72% female; age range 23-­‐57 yr) and IPAH patients (n=30, 60% female; age range 22-­‐56 yr). Older IPAH patients (n=6, 50% female; age range 62-­‐82 yr) were also sampled. Distinct colonies appeared after 13-­‐35 days and exhibited a typical cobblestone morphology. The average frequency of colonies and clonal growth of isolated cells was similar in healthy volunteers and IPAH patients. Age-­‐dependent differences were observed however in the number and frequency of colonies, which declines with age in the control but not in IPAH subjects. The endothelial phenotype was confirmed by immunostaining and flow cytometry, exhibiting endothelial and progenitor markers, but not hematopoietic markers. Endothelial cell functions, including proliferation, angiogenesis, migration and responses to apoptotic stimuli, were compared in cells between passages 4 to 7. IPAH cells showed enhanced angiogenic capacity (tube formation on Matrigel), significantly less apoptosis (lower caspase-­‐3/7 activity) in response to serum and growth factor deprivation, and impaired migratory capacity compared with control ECFCs. Dysfunctional transforming growth factor (TGF)-­‐β and bone morphogenetic protein receptor expression and signalling are implicated in IPAH and were assessed by RT-­‐PCR and western blotting. IPAH and control ECFCs differed in their TGF-­‐β type I (ALK5) receptor expression/signalling and in the expression of other regulatory proteins (e.g. chloride-­‐like intracellular channel-­‐4). Blood-­‐derived ECFCs display an endothelial lineage similar to that of mature endothelial cells. ECFCs from IPAH patients have a distinct functional phenotype and exhibit differences in TGF-­‐β receptor superfamily expression/signalling, which may contribute to endothelial dysfunction and vascular remodelling in IPAH.
Dirichlet-Branes and Ramond-Ramond Charges
Creators: name: Polchinski, Joseph
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that Dirichlet-branes, extended objects defined by mixed Dirichlet-Neumann boundary conditions in string theory, break half of the supersymmetries of the type~II superstring and carry a complete set of electric and magnetic Ramond-Ramond charges. We also find that the product of the electric and magnetic charges is a single Dirac unit, and that the quantum of charge takes the value required by string duality. This is strong evidence that the Dirchlet-branes are intrinsic to type II string theory and are the Ramond-Ramond sources required by string duality. We also note the existence of a previously overlooked 9-form potential in the IIa string, which gives rise to an effective cosmological constant of undetermined magnitude.
description: LaTeX, 10 pages. Minor typos corrected in eq. 8, 9, 13. References added to [11]
Quantum Anomalous Hall Phase Stabilized via Realistic Interactions on a Kagome Lattice
Creators: name: Ren, Yafei
name: Zeng, T. -S.
name: Zhu, W.
name: Sheng, D. N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the quantum phases of spinless fermion at one-third filling on a Kagome lattice featuring a quadratic band touching Fermi point. In the presence of weak first and second nearest-neighbor repulsive interactions ($V_1$ and $V_2$), we demonstrate an interaction driven quantum anomalous Hall effect by employing exact diagonalization and density-matrix renormalization group methods. The time-reversal symmetry is broken spontaneously by forming loop currents that exhibit long-range correlation. Quantized Hall conductance corresponding to Chern number of $\pm1$ is obtained by measuring the pumped charge through inserting flux in a cylinder geometry. We find that the energy gap, which topologically protects the emerging ground states, can be enhanced remarkably by a moderate $V_2 < V_1$ via calculating the spectrum and charge excitation gaps, which highlights the experimentally feasible scheme of realizing interaction driven topological phase by spatially decaying interactions on topologically trivial lattice models.
description: 5 pages, 4 figures
Alternative approaches to the Casalbuoni-Brink-Schwarz Superparticle
Creators: name: Nielsen, Morten
name: Nielsen, N. K.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Wigner's method of induced representations is applied to the N=1 super-Poincare group, and by using a state corresponding to the basic vector of the little group as a Clifford vacuum we show that the spin operator of a supersymmetric point particle obeys Wigner's constraints. As dynamical variables for the particle we use canonical coordinates on the symmetry group manifold. The physical phase space is then constructed using a vielbein formalism. We find that the Casalbuoni-Brink-Schwarz superparticle appears as a special case of our general construction. Finally, the theory is reformulated as a gauge theory where the gauge freedom corresponds to the choice of spin constraints or, equivalently, the free choice of relativistic center of mass. In a special case the gauge symmetry reduces to the well known kappa-symmetry.
description: LaTeX, 31 pages, submitted to Annals of Physics (uses ajour documentclass file)
Callosciurus erythraeus
Creators: name: Cook-Price, Dawn R.
name: Petko, Olga N.
name: Makchai, Sunchai
name: Artchawakom, Taksin
name: Suwanwaree, Pongthep
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Sciuridae
Callosciurus
Callosciurus erythraeus

description: Callosciurus erythraeus (Pallas, 1779)
Notes.
This species was occasionally observed in coastal forested areas in an opportunistic manner. It was captured once in live traps (Table 2), and in five different camera trap locations in central forested areas of both national park and human-disturbed forest (Fig. 6).
description: Published as part of Cook-Price, Dawn R., Petko, Olga N., Makchai, Sunchai, Artchawakom, Taksin & Suwanwaree, Pongthep, 2025, Mammal diversity survey of Ko Pha-ngan in Surat Thani Province, Thailand, pp. 77-102 in ZooKeys 1229 on pages 77-102, DOI: 10.3897/zookeys.1229.118127
Modelling of Flow Dynamics and Nasal Function in Simplified Nasal Airways
Creators: name: Lobb, Edmund G.
Publisher: name: Imperial College London
Year: 2012

description: This work comprises an investigation of the fluid mechanics of nasal airflow, primarily using computational fluid dynamics simulations, though with some flow visualisation experiments. The objective of the work is to provide a basic understanding of the flow phenomena that in turn govern transport and exchange processes in the nasal airways. In keeping with the goal of elucidating the basic fluid mechanics, simplified models of the nasal cavity airway were considered together with two representative realistic models. Computations were performed using a commercially available 3D laminar finite-volume solver (Fluent 6.3.26, ANSYS), for steady and unsteady flow conditions. The reduced models replicate the steady pressure loss vs. flow curve found in realistic geometries, and in the unsteady case, confirm the validity of simple inertance modelling to deduce the form of the pressure-flow loop. By selective inclusion/ exclusion of a simplified middle turbinate, the simulations reveal how the turbinate redirects and controls inspired air. In the absence of the middle turbinate, large scale instabilities were observed in the cavity flow and their strength and distribution were seen to increase concomitant with increasing flow rate. It was further identified that the inclusion of this turbinate reduced large scale flow instability and that flow partitioning was predominantly determined by the impingement of the inspiratory jet on its surface. The consequence of the narrow mean passage width characteristic of the nasal airways is explored by comparing an idealised 2D model with 3D geometries of increasing calibre. A strong interrelationship was found to exist between geometric and flow characteristics. In particular, the narrow width of the normal nasal airways is shown to exert a strongly stabilising effect on the mean flow during inspiration. In 3D, whereas increasing calibre width is associated with a progressive destabilisation of the flow, for the same inspiratory flow rate, there would be a concomitant drop in maximum velocity. The computational results moreover detail the evolution of the time-dependent flow within the simplified anatomies and the instability at the margins of the inspiratory jet are shown to compare well with those found in flow visualisation experiments. In the last part of the thesis, steady modelling of the flow in the anatomically realistic geometries is used to investigate their heat and water exchange capacity as well as the characteristics of particle transport and deposition. These results are related to those found in the idealised models.
Inducible Depletion of Cardiac Thymosin β4: Development and Shortcomings of a Popular Technique in Cardiac Research
Creators: name: Lexow, Jonas Maximilian
Publisher: name: Imperial College London
Year: 2012

description: In reference to recent studies highlighting the importance of Thymosin beta 4 (Tβ4) during embryonic development and its therapeutic potential, an inducible cardiac-specific knockdown of Tβ4 was established to investigate the outcomes of loss of function in adult mammalian hearts. Tβ4shRNAflox/MerCreMer mice were generated with the aim of depleting cardiac Tβ4 expression by RNA interference in a tamoxifen-dependent fashion. In vivo, in vitro and ex vivo approaches showed that tamoxifen treatment of Tβ4shRNAflox/MerCreMer mice does not result in significant down-regulation of Tβ4 mRNA or protein in the heart. Interestingly, higher levels of Tβ4 were identified in cardiac fibroblasts compared to cardiomyocytes. The above analyses suggest that an inducible knockout of Tβ4 would be a more direct, more reliable and more effective means to study loss of function in the adult mammalian heart. In the course of the study, an adverse cardiac phenotype was observed in tamoxifen-treated MerCreMer-positive animals, consisting of perivascular and interstitial fibrosis, decreased cardiac function, a marked inflammatory response and increased expression of factors involved in cardiac remodelling and hypertrophy. This was not related to MerCreMer gene copy number (homo/heterozygosity) but found to be associated with tamoxifen dose, mode of delivery and genetic background. A thorough analysis of related literature revealed that a number of recent publications have failed to include tamoxifen-treated αMHC/MerCreMer controls and some of the presented data may be affected by Cre toxicity. In conclusion, αMHC/MerCreMer mice should be included as controls in the analysis of future studies or alternative inducible systems considered. Recent analyses revealed that IGF-1Ea overexpression in the heart improves the outcome of myocardial infarction in mice. This process has been described on the molecular level but a comprehensive analysis of the subcellular structure of αMHC/IGF-1Ea hearts had not previously been performed. A detailed transmission electron microscope analysis of αMHC/IGF-1Ea hearts revealed previously not described large electron-dense structures inside αMHC/IGF-1Ea cardiomyocytes. The structures resembled large autophagolysosomes although markers of autophagy were neither found to be associated with the structures nor upregulated in the hearts of αMHC/IGF-1Ea mice. Intriguingly lysosomes were identified in the proximity of the structures potentially implying a role in turnover of intracellular material. These results provide further insights into the diverse roles of IGF-1Ea in the heart.
Overt language production of German past participles: investigating (ir-)regularity
Creators: name: Marusch, Tina
name: Jäger, Lena A.
name: Neiß, Leander
name: Burchert, Frank
name: Nickels, Lyndsey
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We report two experiments and Bayesian modelling of the data collected. In both experiments, participants performed a long-lag primed picture naming task. Black-and-white line drawings were used as targets, which were overtly named by the participants. Their naming latencies were measured. In both experiments, primes consisted of past participle verbs (er tanzt/er hat getanzt “he dances/he has danced”) and the relationship between primes and targets was either morphological or unrelated. Experiment 1 additionally had phonologically and semantically related prime-target pairs as well as present tense primes. Both in Experiment 1 and 2, participants showed significantly faster naming latencies for morphologically related targets relative to the unrelated verb primes. In Experiment 1, no priming effects were observed in phonologically and semantically related control conditions. In addition, the production latencies were not influenced by verb type.
Lepton Flavor Violating Dilepton Dijet Signatures from Sterile Neutrinos at Proton Colliders
Creators: name: Antusch, Stefan
name: Cazzato, Eros
name: Fischer, Oliver
name: Hammad, A.
name: Wang, Kechen
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this article we investigate the prospects of searching for sterile neutrinos in lowscale seesaw scenarios via the lepton flavour violating (but lepton number conserving) dilepton dijet signature. In our study, we focus on the final state $e^\pm μ^\mp jj$ at the HL-LHC and the FCC-hh (or the SppC). We perform a multivariate analysis at the detector level including the dominant SM backgrounds from di-top, di-boson, and tri-boson. Under the assumption of the active-sterile neutrino mixings $|V_{ l N}|^2=|θ_e|^2=|θ_μ|^2$ and $|V_{ τN}|^2 = |θ_τ|^2=0$, the sensitivities on the signal production cross section times branching ratio $σ(p p \to l^\pm N)\times {\rm BR} (N \to l^{ \mp} jj)$ and on $|V_{ l N}|^2$ for sterile neutrino mass $M_N$ between 200 and 1000 GeV are derived. For the benchmark $M_N=500$ GeV, when ignoring systematic uncertainties at the HL-LHC (FCC-hh/SppC) with 3 (20) ${\rm ab}^{-1}$ luminosity, the resulting 2-$σ$ limits on $|V_{ l N}|^2$ are $4.9\times 10^{-3}$ ($7.0\times 10^{-5}$), while the 2 -$σ$ limit on $σ\times {\rm BR}$ are $4.4\times10^{-2}$ ($1.6\times10^{-2}$) fb, respectively. The effect of the systematic uncertainty is also studied and found to be important for sterile neutrinos with smaller masses. We also comment on searches with $τ^\pm μ^\mp jj$ and $τ^\pm e^\mp jj$ final states.
description: 20 pages, 9 figures
Speech pathology management of non-progressive dysarthria: a systematic review of the literature
Creators: name: Finch, Emma
name: Rumbach, Anna F.
name: Park, Stacie
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Purpose: The purpose of this study is to conduct a systematic review of interventions for the treatment of non-progressive dysarthria in adults. Materials and methods: Five electronic databases (PubMed, Embase, CINAHL, PSYCINFO, Cochrane Collaboration) were searched for all studies that described and evaluated treatment used for non-progressive dysarthria in adults. Studies were included if (1) participants were adults (18+ years) with a confirmed diagnosis of non-progressive dysarthria, (2) participants received intervention with pre-post outcome data, and (3) the article was published between 2006 and 2017 (including early online publications). Data extracted included the number of participants; etiology; dysarthria type and severity; age; gender; presence of a control group; intervention tasks, frequency and duration; outcome measures; and conclusions. Data extraction was completed by a member of the research team independently and crosschecked by another team member. Results: Of the 6728 articles identified, 21 met the inclusion criteria. The predominant study design was a case study or case series. The methodological quality of the studies varied. Typically, the interventions included impairment-based and activity level tasks targeting conversation. Approximately half of the interventions adhered to a treatment manual. Conclusions: The evidence base to guide treatment for non-progressive dysarthria is increasing, with interventions showing promise in results, participant numbers, and positive participant feedback.Implications for rehabilitationThe evidence base to guide treatment for non-progressive dysarthria is increasing, but remains limited.The majority of evidence is of moderate methodological quality.The emergence of new research indicates that health professionals need to be continuously aware and critically appraise new literature in the area. The evidence base to guide treatment for non-progressive dysarthria is increasing, but remains limited. The majority of evidence is of moderate methodological quality. The emergence of new research indicates that health professionals need to be continuously aware and critically appraise new literature in the area.