title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ñ ÑÐ¾Ð¼Ð¾Ð½Ð¸Ð»Ð°Ð»Ð»Ð¸Ð»Ð¼Ð¾ÑÑÐ¾Ð»Ð¸Ð½Ð¾Ð² Ð½Ð° Ð¼ÐµÐ¶ÑÐ°Ð·Ð½ÑÐ¹ ÑÐºÐ°ÑÐ¾Ðº ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð° Ð² Ð¼Ð¾Ð´ÐµÐ»ÑÐ½ÑÑ Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÑ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ð°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Effect of chromonylallylmorpholines on the interphase jump of electric potential in model lipid membranes
Creators: name: ÐÐ°ÑÑÑÐ½ÑÐº, ÐÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð¼Ð¾Ð´ÐµÐ»ÑÐ½ÑÐµ Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÐµ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ñ
Ð³ÑÐ°Ð½Ð¸ÑÐ½ÑÐ¹ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð» Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ñ
Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÐµ Ð¼Ð¾ÑÑÐ¾Ð»Ð¸Ð½Ð°
Ð³ÑÐ°Ð¼Ð¸ÑÐ¸Ð´Ð¸Ð½ Ð
model lipid membranes
membrane boundary potential
morpholine derivatives
gramicidin A

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description: Morpholine derivatives are widely used in manufacturing and agriculture, as well as in pharmacology. Multiple studies show the possibility of morpholine deÂ­rivatives to influence the functioning of enzymes and receptors, mainly associated with lipid membranes of cells of the central nervous system (CNS), which makes them promising in the treatment of neuropsychiatric diseases associated with imÂ­paired enzymatic and receptor processes.Â Â The aim of this work is to study the effect of morpholine derivatives on the physicochemical properties of lipid membranes. Using electrophysiological and fluorimetric measurements changes in the boundary and dipole potential of the membranes were performed. The effect of morpholine derivatives on model ion channels formed by gramicidin A (GrA) was also evaluated.Â It was found that, depending on the change in the boundary potential of palÂ­mitoyl phosphatidylcholine membranes, morpholine-containing substances can be divided into three groups: with strong, medium and weak effect. It was shown that the change in the boundary potential is due to modulation the dipole component.Single channels formed by GrA were used as a potential-sensitive probe. The results obtained show that the increase in the conductance of GrA channels in the presence of CNV-3 is about 15%, while CNV-58 does not affect this parameÂ­ter. One can assume that change in the GrAâconductance correlates with the change in the dipole potential of membranes.