cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Urinary PCA3 detection in prostate cancer by magnetic nanoparticles coupled with colorimetric enzyme-linked oligonucleotide assay
Creators: name: Yamkamon, Vichanan
name: Htoo, Khin Phyu Pyar
name: Yainoy, Sakda
name: Suksrichavalit, Thummaruk
name: Tangchaikeeree, Tienrat
name: Eiamphungporn, Warawan
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: PCA3
subject: Prostate cancer
subject: Urine
subject: Magnetic nanoparticle
subject: Colorimetric assay
subject: 610

description: PCA3 is one of the most prostate cancer-specific genes described to date. Of note, PCA3 expression is detectable at high level in the urine of prostate cancer (PCa) patients. Accordingly, PCA3 is an ideal biomarker for PCa diagnosis. Several techniques for the measurement of this biomarker in urine have been developed but there are still some drawbacks. In this study, magnetic nanoparticle-based PCR coupled with streptavidin-horseradish peroxidase and a substrate for colorimetric detection was established as a potential assay for urinary PCA3 detection. The method provided a high specificity for PCA3 gene in LNCaP prostate cancer cell line. Additionally, this technique could detect PCA3 at femtogram level which was approximately 1,000-fold more sensitive than the conventional RT-PCR followed by agarose gel electrophoresis. The effectiveness of the method was assessed by PCA3 detection in clinical specimens. The relative PCA3 expression of PCa patients determined by this assay was significantly greater than that of benign prostatic hyperplasia (BPH) patients and healthy controls. The results of our test were comparable with the results of qRT-PCR. The proposed method is promising to distinguish between cancerous and non-cancerous groups. Altogether, this simple assay is practicable and useful for prostate cancer diagnosis.
description: EXCLI Journal;Vol. 19 2020
Correspondence Regarding Belle Chance, Andrews Air Force Base, Maryland
Creators: name: Duffy, Brian P.
name: Cole, Beth
name: Franz, John A.
name: Sager, Jonathan
name: Ackerley, Paul R.
name: J. Rodney Little
Year: 2007
Subjects: subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: PG:77-14
valueUri: https://core.tdar.org/browse/site-name/129253/pg77-14
subject: Building 1966
valueUri: https://core.tdar.org/browse/site-name/128456/building-1966
subject: 18PR447
valueUri: https://core.tdar.org/browse/site-name/11833/18pr447
subject: Building 1968
valueUri: https://core.tdar.org/browse/site-name/128458/building-1968
subject: Building 1967
valueUri: https://core.tdar.org/browse/site-name/128457/building-1967
subject: Belle Chance
valueUri: https://core.tdar.org/browse/site-name/127963/belle-chance
subject: Cemetery
valueUri: https://core.tdar.org/browse/site-type/302/cemetery
subject: Garage
valueUri: https://core.tdar.org/browse/site-type/562/garage
subject: House
valueUri: https://core.tdar.org/browse/site-type/259/house
subject: Shed
valueUri: https://core.tdar.org/browse/site-type/838/shed
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: Andrews Air Force Base
valueUri: https://core.tdar.org/browse/other-keyword/167940/andrews-air-force-base
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Preservation Covenant
valueUri: https://core.tdar.org/browse/other-keyword/167367/preservation-covenant
subject: Quit Claim Deed
valueUri: https://core.tdar.org/browse/other-keyword/167371/quit-claim-deed
subject: Joint Base Andrews
valueUri: https://core.tdar.org/browse/other-keyword/167579/joint-base-andrews
subject: Military Housing Privatization Initiative
valueUri: https://core.tdar.org/browse/other-keyword/167931/military-housing-privatization-initiative
subject: MHPI
valueUri: https://core.tdar.org/browse/other-keyword/167932/mhpi
subject: Consultation
valueUri: https://core.tdar.org/browse/investigation-type/4/consultation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Various correspondences between the Maryland Historic Trust and Andrews Air Force Base regarding the Military Housing Privatization Initiative (MHPI) and other preservation efforts at the historic site of Belle Chance, located at the base. Correspondence packet includes Preservation Covenant and Quit Claim Deed.
The Isospin Asymmetry in Anomalous Fluid Dynamics
Creators: name: Capasso, D.
name: Nair, V. P.
name: Tekel, J.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The dynamics of fluids in which the constituent particles carry nonabelian charges can be described succinctly in terms of group-valued variables via a generalization of the co-adjoint orbit action for particles. This formalism, which is particularly suitable for incorporating anomalies, has previously been used for the chiral magnetic and chiral vorticity effects. Here we consider the similar effect for the isospin which corresponds to an angular asymmetry for neutral pions.
description: 12 pages
Aerobic training and hydroalcoholic extracts of green tea improve pro-oxidant-antioxidant balance and histopathological score in the N-methyl-N-nitrosourea-induced prostate cancer model of rat
Creators: name: Vahabzadeh, Zakaria
name: Molodi, Mohammadraman
name: Nikkho, Bahram
name: Saghebjoo, Marziyeh
name: Saedmocheshi, Saber
name: Zamani, Fatemeh
name: Roshani, Yazdan
name: Babanzadeh, Sina
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Prostate cancer
subject: Pro-oxidant-antioxidant balance
subject: Prostate-specific antigen
subject: Camellia sinensis
subject: Aerobic exercise
subject: 610

description: Green tea is a main resource for catechins. Catechins as antioxidant compounds reduce the production of reactive oxygen species and they have a protective role in the development of cancer. As well as, aerobic exercise change free radicals with two contradictory mechanisms. Aerobic training promotes excessive production of free radicals resulting in oxidative stress. In contrast, it increases the total antioxidant capacity. In this study, effect of aerobic training and hydroalcoholic extract of green tea (HEGT) on the pro-oxidant-antioxidant balance (PAB), prostate-specific antigen (PSA) and histopathological score of cancerous tissue in the N-methyl-N-nitrosourea–induced prostate cancer was investigated. A rat model of prostate cancer was induced by hormonal change and N-Nitroso-N-methylurea (NMU). HEGT 0.1 % and 45 min of aerobic exercise in 5 days a week for eight weeks were scheduled. The presence of major catechins was approved using GC-MS. Histological study, PAB and PSA levels were used to monitor the preventive role of treatments. The prostate weights of cancerous rats were significantly higher than healthy controls (P<0.05). The PAB was only significantly higher in cancerous rats and cancerous rats receiving aerobic exercise (P<0.05). The mean of histological score of cancerous tissue was reduced in rat receiving HEGT and both HEGT and aerobic exercise. The amounts of PSA level did not significantly differ between the groups of this study (P>0.05). Our results provided laboratory and histological documentation for the preventive role of green tea extract in developing prostate cancer via its potential to re-establish the pro-oxidant-antioxidant balance.
description: EXCLI Journal;Vol. 19. 2020, p. 762-772
THE APPLICATION OF WAITING LINES SYSTEM IN IMPROVING CUSTOMER SATISFACTION (A CASE OF KIFIYA FINANCIAL TECH PLC – LEHULU)
Creators: name: ASEFA DEMELIE AREGA
Publisher: name: Zenodo
Year: 2017

description: This study had the aim of assessing the application of waiting lines system in improving customer satisfaction by taking sample Lehulu branches of Kifiya Financials Tech Plc. The study had determined the average arrival rates, the average queue time and average time of service per customer for Lehulu centers (4 sample branches taken namely Arat Kilo, Kazanchis, Addisu Gebeya & Lebu) and besides this, it assessed the impact of psychological aspects of waiting on overall customer satisfaction. The methodologies used for data collection were site observation, in which structured observation check lists were used, a pre-tested/ adopted questionnaire and scheduled interview questions. For the site observation an entire customers randomly visiting the centers within the sampled time-intervals have been accounted for data collection and accordingly 1451 customers queue were considered. A sample of 659 customers was taken for the data collected through the questionnaire to assess customers’ levels of satisfaction towards the queue variables. The queue variables used under the study were perceived waiting time, information provided, the waiting environment and the queue discipline. The response rate of the questionnaire was 572 (86.8%). 30 questionnaires were distributed during pilot test period to conduct different validity tests. Scheduled Interview questions were presented to two area managers of Lehulu to assess the level of understanding the management has on the actual situation of customer waiting lines at the centers and the planed actions to improve it further
Two-Baryon Systems with Twisted Boundary Conditions
Creators: name: Briceno, Raul A.
name: Davoudi, Zohreh
name: Luu, Thomas C.
name: Savage, Martin J.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We explore the use of twisted boundary conditions in extracting the nucleon mass and the binding energy of two-baryon systems, such as the deuteron, from Lattice QCD calculations. Averaging the results of calculations performed with periodic and anti-periodic boundary conditions imposed upon the light-quark fields, or other pair-wise averages, improves the volume dependence of the deuteron binding energy from ~exp(-kappa*L)/L to ~exp(-sqrt(2)kappa*L)/L. However, a twist angle of pi/2 in each of the spatial directions improves the volume dependence from ~exp(-kappa*L)/L to ~exp(-2kappa*L)/L. Twist averaging the binding energy with a random sampling of twist angles improves the volume dependence from ~exp^(-kappa*L)/L to ~exp(-2kappa*L)/L, but with a standard deviation of ~exp(-kappa*L)/L, introducing a signal-to-noise issue in modest lattice volumes. Using the experimentally determined phase shifts and mixing angles, we determine the expected energies of the deuteron states over a range of cubic lattice volumes for a selection of twisted boundary conditions.
description: 20 pages, 3 figures
Roles of kininogen-1, basement membrane specific heparan sulfate proteoglycan core protein, and roundabout homolog 4 as potential urinary protein biomarkers in diabetic nephropathy
Creators: name: Na Nakorn, Piyada
name: Pannengpetch, Supitcha
name: Isarankura-Na-Ayudhya, Patcharee
name: Thippakorn, Chadinee
name: Lawung, Ratana
name: Sathirapongsasuti, Nuankanya
name: Kitiyakara, Chagriya
name: Sritara, Piyamitr
name: Vathesatogkit, Prin
name: Isarankura-Na-Ayudhya, Chartchalerm
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Diabetic nephropathy
subject: Urine
subject: Auantitative proteomics
subject: 610

description: Diabetic nephropathy, a major complication of diabetes mellitus (DM), is increasing worldwide and the large majority of patients have type 2 DM. Microalbuminuria has been used as a diagnostic marker of diabetic nephro­pathy. But owing to its insufficient sensitivity and specificity, other biomarkers are being sought. In addition, the pathophysiology of diabetic nephropathy is not fully understood and declines in renal function occur even without microalbuminuria. In this study, we investigated urinary proteins from three study groups (controls, and type 2 diabetic subjects with or without microalbuminuria). Non-targeted label-free Nano-LC QTOF analysis was conducted to discover underlying mechanisms and protein networks, and targeted label-free Nano-LC QTOF with SWATH was performed to qualify discovered protein candidates. Twenty-eight proteins were identified as candidates and functionally analyzed via String DB, gene ontology and pathway analysis. Four predictive mechanisms were analyzed: i) response to stimulus, ii) platelet activation, signaling and aggregation, iii) ECM-receptor interaction, and iv) angiogenesis. These mechanisms can provoke kidney dysfunction in type 2 diabetic patients via endothelial cell damage and glomerulus structural alteration. Based on these analyses, three proteins (kininogen-1, basement membrane-specific heparan sulfate proteoglycan core protein, and roundabout homolog 4) were proposed for further study as potential biomarkers. Our findings provide insights that may improve methods for both prevention and diagnosis of diabetic nephropathy.
description: EXCLI Journal;Vol. 19. 2020, p. 872-891
An evolutionary continuum from nucleated dwarf galaxies to star clusters
Creators: name: Wang, Kaixiang
name: Peng, Eric W.
name: Liu, Chengze
name: Mihos, J. Christopher
name: Côté, Patrick
name: Ferrarese, Laura
name: Taylor, Matthew A.
name: Blakeslee, John P.
name: Cuillandre, Jean-Charles
name: Duc, Pierre-Alain
name: Guhathakurta, Puragra
name: Gwyn, Stephen
name: Ko, Youkyung
name: Lançon, Ariane
name: Lim, Sungsoon
name: MacArthur, Lauren A.
name: Puzia, Thomas
name: Roediger, Joel
name: Sales, Laura V.
name: Sánchez-Janssen, Rubén
name: Spengler, Chelsea
name: Toloba, Elisa
name: Zhang, Hongxin
name: Zhu, Mingcheng
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Systematic studies have revealed hundreds of ultra-compact dwarf galaxies (UCDs) in the nearby Universe. With half-light radii $r_h$ of approximately 10-100 parsecs and stellar masses $M_*$ $\approx$ $10^6-10^8$ solar masses, UCDs are among the densest known stellar systems. Although similar in appearance to massive globular clusters, the detection of extended stellar envelopes, complex star formation histories, elevated mass-to-light ratio, and supermassive black holes suggest that some UCDs are remnant nuclear star clusters of tidally-stripped dwarf galaxies, or even ancient compact galaxies. However, only a few objects have been found in the transient stage of tidal stripping, and this assumed evolutionary path has never been fully traced by observations. Here we show that 106 galaxies in the Virgo cluster have morphologies that are intermediate between normal, nucleated dwarf galaxies and single-component UCDs, revealing a continuum that fully maps this morphological transition, and fills the `size gap' between star clusters and galaxies. Their spatial distribution and redder color are also consistent with stripped satellite galaxies on their first few pericentric passages around massive galaxies. The `ultra-diffuse' tidal features around several of these galaxies directly show how UCDs are forming through tidal stripping, and that this evolutionary path can include an early phase as a nucleated ultra-diffuse galaxy (UDG). These UCDs represent substantial visible fossil remnants of ancient dwarf galaxies in galaxy clusters, and more low-mass remnants probably remain to be found.
description: Published in Nature. Accepted on September 15
Environmental Assessment for Proposed Construction Projects at the 113th Wing
Creators: name: Fernandez, Rachel
Year: 2016
Subjects: subject: Joint Base Andrews
valueUri: https://core.tdar.org/browse/geographic-keyword/85892/joint-base-andrews
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Building 1125
valueUri: https://core.tdar.org/browse/site-name/96013/building-1125
subject: Building 3217
valueUri: https://core.tdar.org/browse/site-name/128774/building-3217
subject: Building 1228
valueUri: https://core.tdar.org/browse/site-name/94261/building-1228
subject: Building 3110
valueUri: https://core.tdar.org/browse/site-name/118488/building-3110
subject: Building 3029
valueUri: https://core.tdar.org/browse/site-name/128776/building-3029
subject: Building 3216
valueUri: https://core.tdar.org/browse/site-name/128775/building-3216
subject: Building 3215
valueUri: https://core.tdar.org/browse/site-name/128778/building-3215
subject: Building 3111
valueUri: https://core.tdar.org/browse/site-name/128777/building-3111
subject: Building 3213
valueUri: https://core.tdar.org/browse/site-name/128779/building-3213
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Military Structure
valueUri: https://core.tdar.org/browse/site-type/322/military-structure
subject: Historic Church / Religious Structure
valueUri: https://core.tdar.org/browse/site-type/313/historic-church-religious-structure
subject: Repair
valueUri: https://core.tdar.org/browse/other-keyword/55998/repair
subject: Andrews Air Force Base
valueUri: https://core.tdar.org/browse/other-keyword/167940/andrews-air-force-base
subject: Construction
valueUri: https://core.tdar.org/browse/other-keyword/78740/construction
subject: Renovation Project
valueUri: https://core.tdar.org/browse/other-keyword/85060/renovation-project
subject: Environmental Assessment
valueUri: https://core.tdar.org/browse/other-keyword/86419/environmental-assessment
subject: No Adverse Effect
valueUri: https://core.tdar.org/browse/other-keyword/84233/no-adverse-effect
subject: Demolition Project
valueUri: https://core.tdar.org/browse/other-keyword/56011/demolition-project
subject: Consultation
valueUri: https://core.tdar.org/browse/investigation-type/4/consultation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Environmental Assessment of the potential environmental impacts of planned short-range and mid-range construction, demolition, and renovation activities identified in the 2012 Installation Development Plan. Assessment finds no significant impact will be incurred at Joint Base Andrews as a result of these projects.
Characterization of initial fluctuations for the hydrodynamical description of heavy ion collisions
Creators: name: Floerchinger, Stefan
name: Wiedemann, Urs Achim
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Event-by-event fluctuations in the initial conditions for a hydrodynamical description of heavy-ion collisions are characterized. We propose a Bessel-Fourier decomposition with respect to the azimuthal angle, the radius in the transverse plane and rapidity. This allows for a complete characterization of fluctuations in all hydrodynamical fields including energy density, pressure, fluid velocity, shear stress and bulk viscous pressure. It has the advantage that fluctuations can be ordered with respect to their wave length and that they can be propagated mode-by-mode within the hydrodynamical formalism. Event ensembles can then be characterized in terms of a functional probability distribution. For the event ensemble of a Monte Carlo Glauber model, we provide evidence that the latter is close to Gaussian form, thus allowing for a particularly simple characterization of the event distribution.
description: 40 pages, 16 figures
Phenoxodiol sensitizes metastatic colorectal cancer cells to 5-fluorouracil- and oxaliplatin-induced apoptosis through intrinsic pathway
Creators: name: Yaylaci, Esra
name: Onen, Hacer Ilke
name: Yar Saglam, Atiye Seda
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Apoptosis
subject: Colorectal cancer
subject: 5-Fluorouracil
subject: Oxaliplatin
subject: Phenoxodiol
subject: 610

description: Colorectal cancer (CRC) is one of the most common types of cancer seen in the world. 5-Fluorouracil (5-Fu) plus Oxaliplatin (1-OHP) remains the backbone of CRC chemotherapeutics, but with limited success. Phenoxodiol (Pxd) is an isoflavone analog with antitumor activity against various types of cancers, and sensitizes chemoresistant cancer cells to chemotherapeutics including platinum and taxanes. This study was, therefore, undertaken to examine whether Pxd pre-treatment with conventional chemotherapeutic agent(s) 5-Fu and 1-OHP co-administration be a therapeutic strategy for CRC. Cell viability and cytotoxicity were evaluated using dimethyl-thiazolyl diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase assays. The percentage of apoptotic and necrotic cells were determined by fluorescence microscopy analysis. Besides, active Caspase-3 levels by ELISA and relative mRNA levels of Caspase 3 (CASP3), CASP8 and CASP9 genes were determined by quantitative real-time PCR (qPCR) analysis. The pre-treatment of Pxd followed by 5-Fu and 1-OHP co-administration was more effective at inhibiting cell viability than either chemotherapeutic agents treatment alone. When compared to 5-Fu with 1-OHP alone treatment, Pxd pre-treatment overwhelmingly increased apoptotic Caspase-3 activity levels in CRC cells. Moreover, qPCR analyses showed that CASP3 and CASP9 mRNA levels significantly increased after pre-treatment with Pxd followed by 5-Fu and 1-OHP treatments, compared to 5-Fu with 1-OHP alone. Our results suggested that Pxd enhanced the in vitro antitumor activity of 5-Fu and 1-OHP. Our study also suggested that Pxd may be a potential candidate agent in advanced CRC and inclusion of Pxd to the conventional chemotherapeutic agent(s) could be an effective therapeutic strategy for CRC.
description: EXCLI Journal;Vol. 19 2020
Napari Zelda (3D segmentation and Parent-Child Relation in napari) - plugin presentation
Creators: name: Rocco, D'Antuono
Publisher: name: Zenodo
Year: 2023
Subjects: microscopy
image analysis
3D segmentation
bioimaging
data analysis
workflows

description: presentation for the LatAm workshop 2023 "Image data science with Python and Napari"
Paucilactobacillus wasatchensis WASATCHENSIS 2020, COMB. NOV.
Creators: name: Zheng, Jinshui
name: Wittouck, Stijn
name: Salvetti, Elisa
name: Franz, Charles M. A. P.
name: Harris, Hugh M. B.
name: Mattarelli, Paola
name: O'Toole, Paul W.
name: Pot, Bruno
name: Vandamme, Peter
name: Walter, Jens
name: Watanabe, Koichi
name: Wuyts, Sander
name: Felis, Giovanna E.
name: Gänzle, Michael G.
name: Lebeer, Sarah
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Bacteria
Firmicutes
Bacilli
Lactobacillales
Lactobacillaceae
Paucilactobacillus
Paucilactobacillus wasatchensis

description: DESCRIPTIONOF PAUCILACTOBACILLUS WASATCHENSIS COMB. NOV.
Paucilactobacillus wasatchensis (wa.satch.en’sis. N.L. masc. adj. wasatchensis of the Wasatch mountains in Utah, USA, the origin of the type strain).
Basonym: Lactobacillus wasatchensis Oberg et al. 2016, 163 VP
Growth is observed at 30 and 37°C but not at 45 °C. In MRS, only ribose and galactose are fermented [251]. The genome size of the type strain is 1.90 Mbp. The mol% G+C content of DNAis 39.8.
Isolated from spoiled cheddar cheese and from silage.
Thetypestrainis WDC04 T = DSM 29958 T = LMG 28678 T.
Genome sequence accession number: AWTT00000000.
16S rRNA gene accession number: NR_147709.
description: Published as part of Zheng, Jinshui, Wittouck, Stijn, Salvetti, Elisa, Franz, Charles M. A. P., Harris, Hugh M. B., Mattarelli, Paola, O'Toole, Paul W., Pot, Bruno, Vandamme, Peter, Walter, Jens, Watanabe, Koichi, Wuyts, Sander, Felis, Giovanna E., Gänzle, Michael G. & Lebeer, Sarah, 2020, A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae, pp. 2782-2858 in International Journal of Systematic and Evolutionary Microbiology 70 on page 2830, DOI: 10.1099/ijsem.0.004107, http://zenodo.org/record/4730536
The effect of driver's performance on road transport operation: In case of Unique Transport Cross Border Freight Association, Addis Ababa, Ethiopia
Creators: name: Fitsum H/Michael
Publisher: name: Zenodo
Year: 2019

description: History of transportation dates back to the medieval period through the use of domestic animals which are used in transporting heavier loads or humans riding animals for easy conveyance and speed. The industrial revolution in the nineteenth century saw various inventions which changed the phase and means of transportation such as telegraphy. Means of communication became a necessity and independent of the transport of physical objects. Road transport is an essential part of the transport system and the most common form of transport. Road transport is vital to the economic development and social integration of the country. However this sector has face different problems, therefore the study investigates the effect of driver’s performance on road transport operation with reference to Unique Transport Cross Border Freight Association, Addis Ababa, Ethiopia. The objective of the study was to investigate drivers behavior, skill, health, and fatigue influence on road transport operation in unique transport cross borders. A survey was conducted by drawing sample size of 126 from a target population of 175 by using simple random sampling. The researcher used structured questionnaires to collect data. The relationships proposed in the framework were tested using Pearson correlation, and the causal relations were analyzed using regression analysis. And the research has found drivers behavior, driver’s skill, driver’s health and drivers fatigue has a positive and significant influence on road transport operation
Dephomys defua
Creators: name: Musser, Guy G.
name: Carleton, Michael D.
Publisher: name: Zenodo
Year: 1993
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Dephomys
Dephomys defua

description: Dephomys defua (Miller, 1900). Proc. Washington Acad. Sci., 2:635. TYPE LOCALITY: Liberia, Mt Coffee. DISTRIBUTION: Specimens are from Sierra Leone, Guinea (Mt Nimbo), Liberia, Ivory Coast, and Ghana. COMMENTS: Part of the murine fauna endemic to W Africa (see account of Grammomys buntingi). Taxonomy, morphology, range, and habits reviewed by Rosevear (1969) and Van der Straeten (1984).
description: Published as part of Guy G. Musser & Michael D. Carleton, 1993, Order Rodentia - Family Muridae, pp. 501-755 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 590, DOI: 10.5281/zenodo.7353098
description: {"references": ["Rosevear, D. R. 1969. The rodents of West Africa. Trustees of the British Museum (Natural History), London, 677: 1 - 604.", "Van der Straeten, E. 1984. Etude biometrique des genres Dephomys et Stochomys avec quelques notes taxonomiques (Mammalia, Muridae). Revue de Zoologie Africaine, 98: 771 - 798."]}
Extragalactic Foreground Contamination in Temperature-based CMB Lens Reconstruction
Creators: name: Osborne, S. J.
name: Hanson, D.
name: Doré, O.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We discuss the effect of unresolved point source contamination on estimates of the CMB lensing potential, from components such as the thermal Sunyaev-Zel'dovich effect, radio point sources, and the Cosmic Infrared Background. We classify the possible trispectra associated with such source populations, and construct estimators for the amplitude and scale-dependence of several of the major trispectra. We show how to propagate analytical models for these source trispectra to biases for lensing. We also construct a "source-hardened" lensing estimator which experiences significantly smaller biases when exposed to unresolved point sources than the standard quadratic lensing estimator. We demonstrate these ideas in practice using the sky simulations of Sehgal et. al., for cosmic-variance limited experiments designed to mimic ACT, SPT, and Planck.
Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer
Creators: name: Abbastabar, Maryam
name: Sarfi, Mohammad
name: Golestani, Abolfazl
name: Karimi, Ali
name: Pourmand, Gholamreza
name: Khalili, Ehsan
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: LncRNA
subject: Exosome
subject: Bladder cancer
subject: Urine
subject: 610

description: Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors classified as T1 or T2. Exosomes were isolated from urine of BC patients and healthy donors, then characterized according to their shape, size, and exosome markers by Electron Microscopy, Dynamic light scattering, and Western blotting. Exosomal lncRNAs extraction was done to determine the expression levels of PVT-1, ANRIL and PCAT-1 by qRT-PCR. ANRIL and PCAT-1 expression was significantly higher in BC patients compared to normal subjects. To evaluate the performance of the identified lncRNAs for BC detection, we performed ROC curves analysis. The diagnostic accuracy of ANRIL and PCAT-1, measured by AUC, was 0.7229 (sensitivity = 46.67 % and specificity = 87.5 %) and 0.7292 (sensitivity = 43.33 % and specificity = 87.5 %). Transcript levels of lncRNAs in urinary exosomes are potential diagnostic biomarkers in bladder cancer.
description: EXCLI Journal;Vol. 19 2020
Molecular mechanism and health effects of 1,2-Naphtoquinone
Creators: name: Soares, Antonio Garcia
name: Muscara, Marcelo N.
name: Costa, Soraia K. P.
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Naphthoquinone
subject: Free radicals
subject: Inflammation
subject: Cardiovascular system
subject: Review
subject: 610

description: Extensive literature regarding the health side effects of ambient pollutants (AP) are available, such as diesel exhaust particles (DEPs), but limited studies are available on their electrophilic contaminant 1,2-Naphthoquinone (1,2-NQ), enzymatically derived from naphthalene. This review summarizes relevant toxicologic and biological properties of 1,2-NQ as an environmental pollutant or to a lesser degree as a backbone in drug development to treat infectious diseases. It presents evidence of 1,2-NQ-mediated genotoxicity, neurogenic inflammation, and cytotoxicity due to several mechanistic properties, including the production of reactive oxygen species (ROS), that promote cell damage, carcinogenesis, and cell death. Many signal transduction pathways act as a vulnerable target for 1,2-NQ, including kappaB kinase b (IKKbeta) and protein tyrosine phosphatase 1B (PTP1B). Antioxidant molecules act in defense against ROS/RNS-mediated 1,2-NQ responses to injury. Nonetheless, its inhibitory effects at PTP1B, altering the insulin signaling pathway, represents a new therapeutic target to treat diabetes type 2. Questions exist whether exposure to 1,2-NQ may promote arylation of the Keap1 factor, a negative regulator of Nrf2, as well as acting on the sepiapterin reductase activity, an NADPH-dependent enzyme which catalyzes the formation of critical cofactors in aromatic amino acid metabolism and nitric oxide biosynthesis. Exposure to 1,2-NQ is linked to neurologic, behavioral, and developmental disturbances as well as increased susceptibility to asthma. Limited new knowledge exists on molecular modeling of quinones molecules as antitumoral and anti-microorganism agents. Altogether, these studies suggest that 1,2-NQ and its intermediate compounds can initiate a number of pathological pathways as AP in living organisms but it can be used to better understand molecular pathways.
description: EXCLI Journal;Vol. 19. 2020, p. 707-717
Role of Kupffer cells in liver injury induced by CpG oligodeoxynucleotide and flucloxacillin in mice
Creators: name: Gao, Yuying
name: Song, Binbin
name: Aoki, Shigeki
name: Ito, Kousei
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Kupffer cells
subject: Toll-like receptor 9
subject: Fas/Fas ligand
subject: Pro-inflammatory cytokines
subject: Mitochondrial permeability transition
subject: 610

description: CpG oligodeoxynucleotide (CpG-ODN) is a Toll-like receptor 9 (TLR9) agonist that can induce innate immune responses. In a previous study, flucloxacillin (FLUX; 100 mg/kg, gavage)-induced liver injury in mice was enhanced by co-administration of CpG-ODN (40 μg/mouse, intraperitoneally). In this study, the mechanism of CpG-ODN sensitization to FLUX-induced liver injury was further investigated in mice inhibited of Kupffer cells (KCs) function by gadolinium chloride (GdCl3; 10 mg/kg, intravenously). GdCl3-treated mice administrated with CpG-ODN and FLUX showed lower liver injury than wild-type (WT) mice treated with CpG-ODN and FLUX. Upregulation of Fas and FasL by CpG-ODN was also inhibited in GdCl3-treated mice and mitochondrial swelling in response to FLUX failed to occur regardless of pre-treatment with CpG-ODN. When FasL-mutant gld/gld mice were treated with CpG-ODN, mitochondrial swelling in response to FLUX was also inhibited. These results suggest that KCs play an essential role in liver injury induced by CpG-ODN and FLUX. CpG-ODN may activate KCs, resulting in induction of Fas/FasL-mediated apoptosis of hepatocytes. The Fas/FasL pathway may also be an upstream regulator of CpG-ODN- and FLUX-induced changes in mitochondrial permeability transition. These results enhance our understanding of the mechanism of the adjuvant effect of CpG-ODN in this mouse model of liver injury.
description: EXCLI Journal;Vol. 19 2020
title: Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome
title: A randomized clinical trial
titleType: AlternativeTitle
Creators: name: Khalighi Sikaroudi, Masoumeh
name: Mokhtare, Marjan
name: Shidfar, Farzad
name: Janani, Leila
name: Faghihi Kashani, AmirHossein
name: Masoodi, Mohsen
name: Agah, Shahram
name: Dehnad, Afsaneh
name: Shidfar, Shahrzad
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Irritable bowel syndrome
subject: Vitamin D3
subject: Clinical symptoms
subject: Serotonin
subject: Randomized controlled trial
subject: 610

description: Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from the lumen due to stress and inflammation. The aim of this study was to evaluate the effect of vitamin D3 supplementation on the pathogenesis of diarrhea-predominant IBS (IBS-D). Seventy-four IBS-D patients (age: 18-65 y) participated in a randomized, double-blind, placebo-controlled trial study from February 2017 to May 2018, at Rasoul-e-Akram Hospital, Tehran, Iran. Subjects were allocated into two groups receiving 50,000 IU/week of vitamin D3 or placebo for 9 weeks. IBS severity score system (IBS-SSS), IBS-quality of life questionnaire (QoL), hospital anxiety and depression Scale (HADs), visceral sensitivity index (VSI) and serum 25(OH) vitamin D3, serotonin, 5-hydroxy-indole acetic acid and ratio of 5-HIAA/5-HT were evaluated before and after the interventions. Symptoms severity, QoL, HADs-depression, and VSI score improved significantly in the vitamin D group as compared to the placebo group (P-values: <0.001, 0.049, 0.023, and 0.008; respectively). There were no significant differences in abdominal bloating, HADs-anxiety, serum 5-HT, 5-HIAA, and 5-HIAA/5-HT between the two groups at the end of the study. Based on our results, we recommend serum vitamin D be evaluated in the process of treatment of these patients to ameliorate symptoms and quality life of IBS-D patients with vitamin D deficiency and/or insufficiency.
description: EXCLI Journal;Vol. 19. 2020, p. 652-667
Dephomys eburnea
Creators: name: Musser, Guy G.
name: Carleton, Michael D.
Publisher: name: Zenodo
Year: 1993
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Dephomys
Dephomys eburnea

description: Dephomys eburnea (Heim de Balsac et Bellier, 1967). Mammalia, 31:157. TYPE LOCALITY: Ivory Coast, Lamto. DISTRIBUTION: Records are from Ivory Coast and Liberia. COMMENTS: Originally described as a subspecies of defua (see discussion and references in Rosevear, 1969), but shown to be a separate species by Van der Straeten (1984). Part of the murine fauna endemic to W Africa (see account of Grammomys buntingi). Chromosomal data reported by Tranier and Dosso (1979).
description: Published as part of Guy G. Musser & Michael D. Carleton, 1993, Order Rodentia - Family Muridae, pp. 501-755 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 590, DOI: 10.5281/zenodo.7353098
description: {"references": ["Rosevear, D. R. 1969. The rodents of West Africa. Trustees of the British Museum (Natural History), London, 677: 1 - 604.", "Van der Straeten, E. 1984. Etude biometrique des genres Dephomys et Stochomys avec quelques notes taxonomiques (Mammalia, Muridae). Revue de Zoologie Africaine, 98: 771 - 798.", "Tranier, M., and H. Dosso. 1979. Recherches caryotypiques sur les rongeurs de Cote d'Ivoire: Resultats preliminaires pour les milieux fermes. Annales de l'Universite d'Abidjan, ser. E (Ecologie), 12: 181 - 183."]}
Power line communication based real time train tracking system for Addis Ababa light rail transit
Creators: name: Hailu, Solomon Firew
Publisher: name: Zenodo
Year: 2015

description: In railway traffics the low friction between wheel and rail causes long braking distances, normally much longer than the driver"s sight distance, i.e. if the driver starts the braking when he discovers a problem on the track it is too late to stop the train. The conclusion will be that the railway traffic can not only rely on the driver for the traffic safety, there must also be a signaling or even an automatic surveyor system, which can supervise the positions of different trains along the track and organize the traffic. Having the traffics information on the track helps to avoid situations of conflict and those that might be potentially unsafe.

There are different train detection systems in service worldwide. Track circuit, Axle counter and GPS are the most prevailed approaches. The first two types provide the information that whether the section is occupied or not. They don"t provide the information “where exactly the train is?” Beside Axle counter has huge installation cost and maintenance cost. Regarding GPS, since it is using satellites to determine the location of the train and the accuracy is dependent on the no of satellites tracked, the error spread is variable. In addition to this it doesn"t operate in tunnels like we have for A.A LRT (Addis Ababa Light Rail Transit) track, from St. George church to Atikilit tera. Not only these but also since the satellites are administered by third party, the operation is totally out of the control of the railway company
Progenitor delay-time distribution of short gamma-ray bursts: Constraints from observations
Creators: name: Hao, Jing-Meng
name: Yuan, Ye-Fei
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context. The progenitors of short gamma-ray bursts (SGRBs) have not yet been well identified. The most popular model is the merger of compact object binaries (NS-NS/NS-BH). However, other progenitor models cannot be ruled out. The delay-time distribution of SGRB progenitors, which is an important property to constrain progenitor models, is still poorly understood. Aims. We aim to better constrain the luminosity function of SGRBs and the delay-time distribution of their progenitors with newly discovered SGRBs. Methods. We present a low-contamination sample of 16 Swift SGRBs that is better defined by a duration shorter than 0.8 s. By using this robust sample and by combining a self-consistent star formation model with various models for the distribution of time delays, the redshift distribution of SGRBs is calculated and then compared to the observational data. Results. We find that the power-law delay distribution model is disfavored and that only the lognormal delay distribution model with the typical delay tau >= 3 Gyr is consistent with the data. Comparing Swift SGRBs with T90 > 0.8 s to our robust sample (T90 < 0.8 s), we find a significant difference in the time delays between these two samples. Conclusions. Our results show that the progenitors of SGRBs are dominated by relatively long-lived systems (tau >= 3 Gyr), which contrasts the results found for Type Ia supernovae. We therefore conclude that primordial NS-NS systems are not favored as the dominant SGRB progenitors. Alternatively, dynamically formed NS-NS/BH and primordial NS-BH systems with average delays longer than 5 Gyr may contribute a significant fraction to the overall SGRB progenitors.
description: 8 pages, 6 figures, Astron. Astrophys. in press
Skyrmion-Excited Spin Wave Fractal Network
Creators: name: Tang, Nan
name: Liyanage, W. L. N. C.
name: Montoya, Sergio A.
name: Patel, Sheena
name: Quigley, Lizabeth J.
name: Grutter, Alexander J.
name: Fitzsimmons, Michael R.
name: Sinha, Sunil
name: Borchers, Julie A.
name: Fullerton, Eric E.
name: DeBeer-Schmitt, Lisa
name: Gilbert, Dustin A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Magnetic skyrmions exhibit unique, technologically relevant pseudo-particle behaviors which arise from their topological protection, including well-defined, three-dimensional dynamic modes that occur at microwave frequencies. During dynamic excitation, spin waves are ejected into the interstitial regions between skyrmions, creating the magnetic equivalent of a turbulent sea. However, since the spin waves in these systems have a well-defined length scale, and the skyrmions are on an ordered lattice, ordered structures from spin wave interference can precipitate from the chaos. This work uses small angle neutron scattering (SANS) to capture the dynamics in hybrid skyrmions and investigate the spin wave structure. Performing simultaneous ferromagnetic resonance and SANS, the diffraction pattern shows a large increase in low-angle scattering intensity which is present only in the resonance condition. This scattering pattern is best fit using a mass fractal model, which suggests the spin waves form a long-range fractal network. The fractal structure is constructed of fundamental units with a size that encodes the spin wave emissions and are constrained by the skyrmion lattice. These results offer critical insights into the nanoscale dynamics of skyrmions, identify a new dynamic spin wave fractal structure, and demonstrates SANS as a unique tool to probe high-speed dynamics.
Complex Solitary Wave Dynamics, Pattern Formation, and Chaos in the Gain-Loss Nonlinear Schrödinger Equation
Creators: name: Anderson, Justin Q.
name: Ryan, Rachel A.
name: Wu, Mingzhong
name: Carr, Lincoln D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A numerical exploration of a gain-loss nonlinear Schrödinger equation was carried out utilizing over 180000 core hours to conduct more than 10000 unique simulations in an effort to characterize the model's six dimensional parameter space. The study treated the problem in full generality, spanning a minimum of eight orders of magnitude for each of three linear and nonlinear gain terms and five orders of magnitude for higher order nonlinearities. The gain-loss nonlinear Schrödinger equation is of interest as a model for spin wave envelopes in magnetic thin film active feedback rings and analogous driven damped nonlinear physical systems. Bright soliton trains were spontaneously driven out of equilibrium and behaviors stable for tens of thousands of round trip times were numerically identified. Nine distinct complex dynamical behaviors with lifetimes on the order of ms were isolated as part of six identified solution classes. Numerically located dynamical behaviors include: (1) Low dimensional chaotic modulations of bright soliton trains; (2) spatially symmetric/asymmetric interactions of solitary wave peaks; (3) dynamical pattern formation and recurrence; (4) steady state solutions and (5) intermittency. Simulations exhibiting chaotically modulating bright soliton trains were found to qualitatively match previous experimental observations. Ten new dynamical behaviors, eight demonstrating long lifetimes, are predicted to be observable in future experiments.
description: 28 pages, 13 figures, 12 animations online
ACCESS TO BANK LOANS, INCOME DISTRIBUTION AND ECONOMIC GROWTH IN AGENT BASED MODELING: EVIDENCE FROM EVOLUTIONARY PERSPECTIVE
Creators: name: Atnafu Gebremeskel
Publisher: name: Zenodo
Year: 2017

description: This doctoral dissertation consists of three inter-related studies which constitute its main text, with introductory and summary chapters. The three main studies share a common feature in that they investigate the link between access to bank loans, income distribution and productivity growth. The second chapter is a theoretical framework that uses agent-based computational economics (ACE) to detect the link between access to bank loans and functional income distribution. The third chapter uses Ethiopian firm-level and national income data to validate the second chapter. The fourth chapter investigates the effect of functional income distribution on productivity growth from an evolutionary economic perspective.
Wi-Fi Offload: Tragedy of the Commons or Land of Milk and Honey?
Creators: name: Zwickl, Patrick
name: Fuxjaeger, Paul
name: Gojmerac, Ivan
name: Reichl, Peter
Publisher: name: arXiv
Year: 2013
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: Fueled by its recent success in provisioning on-site wireless Internet access, Wi-Fi is currently perceived as the best positioned technology for pervasive mobile macro network offloading. However, the broad transitions of multiple collocated operators towards this new paradigm may result in fierce competition for the common unlicensed spectrum at hand. In this light, our paper game-theoretically dissects market convergence scenarios by assessing the competition between providers in terms of network performance, capacity constraints, cost reductions, and revenue prospects. We will closely compare the prospects and strategic positioning of fixed line operators offering Wi-Fi services with respect to competing mobile network operators utilizing unlicensed spectrum. Our results highlight important dependencies upon inter-operator collaboration models, and more importantly, upon the ratio between backhaul and Wi-Fi access bit-rates. Furthermore, our investigation of medium- to long-term convergence scenarios indicates that a rethinking of control measures targeting the large-scale monetization of unlicensed spectrum may be required, as otherwise the used free bands may become subject to tragedy-of-commons type of problems.
description: Workshop on Spectrum Sharing Strategies for Wireless Broadband Services, IEEE PIMRC'13, to appear 2013