cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fermi-Dirac Integrals in Degenerate Regimes: A Novel Asymptotic Expansion
Creators: name: Birrell, Jeremiah
name: Formanek, Martin
name: Steinmetz, Andrew
name: Yang, Cheng Tao
name: Rafelski, Johann
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We characterize in a novel manner the physical properties of the low temperature Fermi gas in the degenerate domain as a function of temperature and chemical potential. For the first time we obtain low temperature $T$ results in the domain where several fermions are found within a de Broglie spatial cell. In this regime, the usual high degeneracy Sommerfeld expansion fails. The other known semi-classical Boltzmann domain applies when fewer than one particle is found in the de Broglie cell. We also improve on the understanding of the Sommerfeld expansion in the regime where the chemical potential is close to the mass and also in the high temperature regime. In these calculcations we use a novel characterization of the Fermi distribution allowing the separation of the finite and zero temperature phenomena. The relative errors of the three approximate methods (Boltzmann limit, Sommerfeld expansion, and the new domain of several particles in the de Broglie cell) are quantified.
description: 35 pages 1+7 double figures, v2 format accepted for publication in the International Journal of Theoretical Physics
A note on the metrizability of spaces
Creators: name: Weiss, Ittay
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 54E35

description: With the blessing of hind sight we consider the problem of metrizability and show that the classical Bing-Nagata-Smirnov Theorem and a more recent result of Flagg give complementary answers to the metrization problem, that are in a sense dual to each other.
description: 3 pages54E35
Sphiggurus villosus
Creators: name: Woods, Charles A.
Publisher: name: Zenodo
Year: 1993
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Erethizontidae
Sphiggurus
Sphiggurus villosus

description: Sphiggurus villosus (F. Cuvier, 1823). Mem. Mus. Hist. Nat. Paris, 9:434. TYPE LOCALITY: Brazil, mountains near Rio de Janeiro, Corcoracto. DISTRIBUTION: Minas Gerais to Rio Grande do Sul (SE Brazil). COMMENTS: Considered a distinct species by Husson (1978:489). Cabrera (1961:600-601) included this species in insidiosus; see comment under Sphiggurus; formerly included in Coendou.
description: Published as part of Charles A. Woods, 1993, Order Rodentia - Suborder Hystricognathi, pp. 771-806 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 777, DOI: 10.5281/zenodo.7353083
description: {"references": ["Husson, A. M. 1978. The mammals of Suriname. E. J. Brill, Leiden, 569 pp., 160 pls."]}
Modeling the Mesoscale Transport of Lithium-Magnetite Electrodes Using Insight from Discharge and Voltage Recovery Experiments
Creators: name: Knehr, K. W.
name: Brady, Nicholas William
name: Cama, Christina A.
name: Bock, David C.
name: Lin, Zhou
name: Lininger, Christianna Naomi
name: Marschilok, Amy C.
name: Takeuchi, Kenneth J.
name: Takeuchi, Esther S.
name: West, Alan C.
Publisher: name: Columbia University
Year: 2015
Subjects: subject: Electrochemistry
subject: Electrolytic cells--Mathematical models
subject: Nanocrystals
subject: Lithium ion batteries
subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Electrical engineering

description: A multi-scale mathematical model, which accounts for mass transport on the crystal and agglomerate length-scales, is used to investigate the electrochemical performance of lithium-magnetite electrochemical cells. Experimental discharge and voltage recovery data are compared to three sets of simulations, which incorporate crystal-only, agglomerate-only, or multi-scale transport effects. Mass transport diffusion coefficients are determined by fitting the simulated voltage recovery times to experimental data. In addition, a further extension of the multi-scale model is proposed which accounts for the impact of agglomerate size distributions on electrochemical performance. The results of the study indicate that, depending on the crystal size, the low utilization of the active material is caused by transport limitations on the agglomerate and/or crystal length-scales. For electrodes composed of small crystals (6 and 8 nm diameters), it is concluded that the transport limitations in the agglomerate are primarily responsible for the long voltage recovery times and low utilization of the active mass. In the electrodes composed of large crystals (32 nm diameter), the slow voltage recovery is attributed to transport limitations on both the agglomerate and crystal length-scales.
A Measurement Study of ARM Virtualization Performance
Creators: name: Dall, Christoffer
name: Li, Shih-Wei
name: Lim, Jin Tack
name: Nieh, Jason
Publisher: name: Columbia University
Year: 2015
Subjects: Computer architecture
Computers
Computer science

description: ARM servers are becoming increasingly common, making server technologies such as virtualization for ARM of growing importance. We present the first in-depth study of ARM virtualization performance on ARM server hardware, including measurements of two popular ARM and x86 hypervisors, KVM and Xen. We show how the ARM hardware support for virtualization can support much faster transitions between the VM and the hypervisor, a key hypervisor operation. However, current hypervisor designs, including both KVM (Type 1) and Xen (Type 2), are not able to lever- age this performance benefit in practice for real application workloads. We discuss the reasons why and show that other factors related to hypervisor software design and implementation have a larger role in overall performance than the speed of micro architectural operations. Based on our measurements, we discuss changes to ARM's hardware virtualization support that can potentially bridge the gap to bring its faster virtual machine exit mechanism to modern Type 2 hypervisors running real applications. These changes have been incorporated into the latest ARM architecture.
Chinchillidae Bennett 1833
Creators: name: Woods, Charles A.
Publisher: name: Zenodo
Year: 1993
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Chinchillidae

description: Family Chinchillidae Bennett, 1833. Proc. Zool. Soc. London, 1833:58. SYNONYMS: Lagostomidae.
description: Published as part of Charles A. Woods, 1993, Order Rodentia - Suborder Hystricognathi, pp. 771-806 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 777, DOI: 10.5281/zenodo.7353083
Additional file 1 of Machine learning models for identifying pre-frailty in community dwelling older adults
Creators: name: Sajeev, Shelda
name: Champion, Stephanie
name: Maeder, Anthony
name: Gordon, Susan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Appendix A.
Ponatinib and other clinically approved inhibitors of Src and Rho-A kinasesabrogate dengue virus serotype 2- induced endothelial permeability
Creators: name: Sreekumar, Eswaran
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310706
subject: Virology
classificationCode: 310702
subject: Infectious agents

description: Ponatinib and other clinically approved inhibitors of Src and Rho-A kinasesabrogate dengue virus serotype 2- induced endothelial permeability
Srishti Rajkumar Mishra 1#, Ayan Modak1, Mansi Awasthi1#, Archana Sobha 2, Easwaran Sreekumar1,3*
1Molecular Virology Laboratory; 2Animal Research Facility, Rajiv Gandhi Centre forBiotechnology (RGCB), Thiruvananthapuram 695014, Kerala, India3Molecular Bioassay Laboratory, Institute of Advanced Virology (IAV), Bio360 LifeSciences Park, Thiruvananthapuram-695317, Kerala, India#Regional Centre for Biotechnology (RCB), Faridabad, New Delhi
*Corresponding author (Easwaran Sreekumar; Molecular Virology Laboratory; RajivGandhi Centre for Biotechnology (RGCB), Thycaud P.O, Thiruvananthapuram695014, Kerala, India; Tel:+91-9447698943; E-mail: esreekumar@rgcb.res.in;)

Severe dengue often presents as shock syndrome with enhanced vascular permeability and plasma leakage into tissue spaces. In vitro studies have documented the role of Src family kinases (SFKs) and RhoA-kinases (ROCK) in dengue virus serotype 2 (DENV2)-induced endothelial permeability. Here, we show that the FDA-approved SFK inhibitors Bosutinib, Vandatenib and Ponatinib, as well as the ROCK inhibitors, Netarsudil and Ripasudil significantly inhibit DENV2-induced endothelial permeability. In cultured telomerase immortalized human microvascular endothelial cells (HMEC-1), treatment with these inhibitors reduced the phosphorylation of VE-Cadherin, Src and myosin light chain 2 (MLC2) proteins that were upregulated during DENV2 infection. It also prevented the loss of VE-cadherin from the inter-endothelial cell junctions induced by viral infection. In in-vivo studies using DENV2-infected AG129 IFN receptor-a/b/g deficient mice, ponatinib, when administered 24h post-infection onwards, demonstrated significant benefits in improving body weight, clinical outcomes, and survival rates. While all virus-infected, untreated mice died by day-10 post-infection, 80% of the ponatinib-treated mice survived, and approximately 60% were still alive at the end of the 15-day observation period. The treatment also significantly reduced disease severity factors such as vascular leakage, thrombocytopenia; and restored liver function. Comparable effects were observed even when ponatinib treatment was initiated after symptom onset. The results highlight ponatinib as an effective therapeutic option in severe dengue; and also a similar potential for other FDA- approved SFK and ROCK inhibitors.
Additional file 2 of Machine learning models for identifying pre-frailty in community dwelling older adults
Creators: name: Sajeev, Shelda
name: Champion, Stephanie
name: Maeder, Anthony
name: Gordon, Susan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Appendix B.
LDAmy, an α-amylase from Colorado potato beetle (Leptinotarsa decemlineata) with transglycosylation activity
Creators: name: Hámori, Csaba
name: Kandra, Lili
name: Gyémánt, Gyöngyi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Potential of α-amylase from the gut of Leptinotarsa decemlineata (LDAmy) to catalyse transfer reactions was investigated. LDAmy as a component of insect gut extract showed significant transfer activity on reducing-end- and both-end-protected maltoheptamer substrates. Transfer reaction was examined using purified enzyme, 2-chloro-4-nitrophenyl β-d-glucopyranoside as acceptor and starch and maltooligosaccharides as donors. In addition to suitability of various donors, effect of pH and acetonitrile (MeCN) concentration were also studied. The reactions were followed using separation of reaction products by a reversed phase HPLC method. LDAmy catalysed the hydrolysis and transglycosylation of the both-end-protected substrate 4,6-O-benzylidene-4-nitrophenyl β-maltoheptaoside in parallel reactions. Shorter and longer both-end-protected products with degree of polymerization 4–10 were formed. Identification of products was carried out based on HPLC retention time, UV and mass spectra. Ratio of transglycosylation to hydrolysis reached 0.5 in presence of 20% MeCN as organic solvent. Aromatic protecting group at the non-reducing end was favourable for transfer reaction. Lack of the mobile loop and presence of more nonpolar aromatic moieties near to the active site may be the reason for the enhanced transfer activity of LDAmy based on the comparison of the sequence and structure of mammalian and insect-derived α-amylases.HighlightsTransferase activity of Colorado potato beetle derived α-amylase LDAmy is presented.Effect of pH and organic co-solvent on transfer reaction of LDAmy were studied.Shorter and longer products were formed from a both-end protected maltoheptamer.The unusual transfer ability was explained by sequence differences of α-amylases. Transferase activity of Colorado potato beetle derived α-amylase LDAmy is presented. Effect of pH and organic co-solvent on transfer reaction of LDAmy were studied. Shorter and longer products were formed from a both-end protected maltoheptamer. The unusual transfer ability was explained by sequence differences of α-amylases.
Three-dimensional simulations of near-surface convection in main-sequence stars - II. Properties of granulation and spectral lines
Creators: name: Beeck, Benjamin
name: Cameron, Robert H.
name: Reiners, Ansgar
name: Schüssler, Manfred
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The atmospheres of cool main-sequence stars are structured by convective flows from the convective envelope that penetrate the optically thin layers and lead to structuring of the stellar atmospheres analogous to solar granulation. The flows have considerable influence on the 3D structure of temperature and pressure and affect the profiles of spectral lines formed in the photosphere. For the set of six 3D radiative (M)HD simulations of cool main-sequence stars described in the first paper of this series, we analyse the near-surface layers. We aim at describing the properties of granulation of different stars and at quantifying the effects on spectral lines of the thermodynamic structure and flows of 3D convective atmospheres. We detected and tracked granules in brightness images from the simulations to analyse their statistical properties, as well as their evolution and lifetime. We calculated spatially resolved spectral line profiles using the line synthesis code SPINOR. To enable a comparison to stellar observations, we implemented a numerical disc-integration, which includes (differential) rotation. Although the stellar parameters change considerably along the model sequence, the properties of the granules are very similar. The impact of the 3D structure of the atmospheres on line profiles is measurable in disc-integrated spectra. Line asymmetries caused by convection are modulated by stellar rotation. The 3D structure of cool stellar atmospheres as shaped by convective flows has to be taken into account when using photospheric lines to determine stellar parameters.
description: 18 pages, 22 figures, 3 tables; accepted for publication in A&A
Ponatinib and other clinically approved inhibitors of Src and Rho-A kinasesabrogate dengue virus serotype 2- induced endothelial permeability
Creators: name: Sreekumar, Eswaran
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310706
subject: Virology
classificationCode: 310702
subject: Infectious agents

description: Ponatinib and other clinically approved inhibitors of Src and Rho-A kinasesabrogate dengue virus serotype 2- induced endothelial permeability
Srishti Rajkumar Mishra 1#, Ayan Modak1, Mansi Awasthi1#, Archana Sobha 2, Easwaran Sreekumar1,3*
1Molecular Virology Laboratory; 2Animal Research Facility, Rajiv Gandhi Centre forBiotechnology (RGCB), Thiruvananthapuram 695014, Kerala, India3Molecular Bioassay Laboratory, Institute of Advanced Virology (IAV), Bio360 LifeSciences Park, Thiruvananthapuram-695317, Kerala, India#Regional Centre for Biotechnology (RCB), Faridabad, New Delhi
*Corresponding author (Easwaran Sreekumar; Molecular Virology Laboratory; RajivGandhi Centre for Biotechnology (RGCB), Thycaud P.O, Thiruvananthapuram695014, Kerala, India; Tel:+91-9447698943; E-mail: esreekumar@rgcb.res.in;)

Severe dengue often presents as shock syndrome with enhanced vascular permeability and plasma leakage into tissue spaces. In vitro studies have documented the role of Src family kinases (SFKs) and RhoA-kinases (ROCK) in dengue virus serotype 2 (DENV2)-induced endothelial permeability. Here, we show that the FDA-approved SFK inhibitors Bosutinib, Vandatenib and Ponatinib, as well as the ROCK inhibitors, Netarsudil and Ripasudil significantly inhibit DENV2-induced endothelial permeability. In cultured telomerase immortalized human microvascular endothelial cells (HMEC-1), treatment with these inhibitors reduced the phosphorylation of VE-Cadherin, Src and myosin light chain 2 (MLC2) proteins that were upregulated during DENV2 infection. It also prevented the loss of VE-cadherin from the inter-endothelial cell junctions induced by viral infection. In in-vivo studies using DENV2-infected AG129 IFN receptor-a/b/g deficient mice, ponatinib, when administered 24h post-infection onwards, demonstrated significant benefits in improving body weight, clinical outcomes, and survival rates. While all virus-infected, untreated mice died by day-10 post-infection, 80% of the ponatinib-treated mice survived, and approximately 60% were still alive at the end of the 15-day observation period. The treatment also significantly reduced disease severity factors such as vascular leakage, thrombocytopenia; and restored liver function. Comparable effects were observed even when ponatinib treatment was initiated after symptom onset. The results highlight ponatinib as an effective therapeutic option in severe dengue; and also a similar potential for other FDA- approved SFK and ROCK inhibitors.
Evolution of the cosmic web
Creators: name: Cautun, Marius
name: van de Weygaert, Rien
name: Jones, Bernard J. T.
name: Frenk, Carlos S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The cosmic web is the largest scale manifestation of the anisotropic gravitational collapse of matter. It represents the transitional stage between linear and non-linear structures and contains easily accessible information about the early phases of structure formation processes. Here we investigate the characteristics and the time evolution of morphological components since. Our analysis involves the application of the NEXUS Multiscale Morphology Filter (MMF) technique, predominantly its NEXUS+ version, to high resolution and large volume cosmological simulations. We quantify the cosmic web components in terms of their mass and volume content, their density distribution and halo populations. We employ new analysis techniques to determine the spatial extent of filaments and sheets, like their total length and local width. This analysis identifies cluster and filaments as the most prominent components of the web. In contrast, while voids and sheets take most of the volume, they correspond to underdense environments and are devoid of group-sized and more massive haloes. At early times the cosmos is dominated by tenuous filaments and sheets, which, during subsequent evolution, merge together, such that the present day web is dominated by fewer, but much more massive, structures. The analysis of the mass transport between environments clearly shows how matter flows from voids into walls, and then via filaments into cluster regions, which form the nodes of the cosmic web. We also study the properties of individual filamentary branches, to find long, almost straight, filaments extending to distances larger than 100Mpc/h. These constitute the bridges between massive clusters, which seem to form along approximatively straight lines.
description: 56 pages, 61 figures, accepted for publication in MNRAS
Additional file 1 of Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias
Creators: name: Baiardi, Simone
name: Quadalti, Corinne
name: Mammana, Angela
name: Dellavalle, Sofia
name: Zenesini, Corrado
name: Sambati, Luisa
name: Pantieri, Roberta
name: Polischi, Barbara
name: Romano, Luciano
name: Suffritti, Matteo
name: Bentivenga, Giuseppe Mario
name: Randi, Vanda
name: Stanzani-Maserati, Michelangelo
name: Capellari, Sabina
name: Parchi, Piero
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 1: Table S1. Clinical features and results of indicative biomarkers in the DLB group. Table S2. CSF NfL, GFAP, and AD core biomarker values across diagnostic groups. Table S3. Plasma NfL, GFAP, and p-tau181 values across diagnostic groups. Table S4. CSF and plasma NfL, GFAP, and p-tau181 across FTD phenotypic continuum. Table S5. CSF and plasma NfL, GFAP, and p-tau181 in genetic and sporadic FTD. Fig. S1. Plasma NfL levels in the SNAP group according to the clinical presentation. Fig. S2. Accuracy of plasma NfL, p-tau181, and GFAP in discriminating between healthy controls and disease groups. Fig. S3. CSF and plasma diagnostic accuracies for each biomarker across disease groups. Fig. S4. Plasma biomarker levels in CBS and DLB according to the amyloid status (left) and ROC curves after excluding A+ cases in non-AD disease groups (right).
X-Ray Diffraction Computed Tomography for Structural Analysis of Electrode Materials in Batteries
Creators: name: Jensen, Kirsten M. Ø.
name: Yang, Xiaohao
name: Laveda, Josefa Vidal
name: Zeier, Wolfgang G.
name: See, Kimberly A.
name: Di Michiel, Marco
name: Melot, Brent
name: Corr, Serena
name: Billinge, Simon
Publisher: name: Columbia University
Year: 2015
Subjects: subject: X-rays--Diffraction
subject: Electrodes--Materials
subject: Electric batteries
subject: Electrochemistry
subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Electrical engineering

description: We report the use of X-ray diffraction in combination with computed tomography to provide quantitative information of a coin cell Li-ion battery and a commercial Ni/MH AAA battery for the first time. This technique allows for structural information to be garnered and opens up the possibility of tracking nanostructural changes in operandi. In the case of the cylindrically wound, standard AAA Ni/MH cell, we were able to map all the different phases in the complex geometry, including anode, cathode, current collector and casing, as well as amorphous phases such as the binder and separator. In the case of a Li-ion coin cell battery, we show how the X-ray diffraction tomography data can be used to map crystal texture of the LiCoO2 particles over the cathode film. Our results reveal that the LiCoO2 microparticles show a high degree of preferred orientation, but that this effect is not homogenous over the film, which may affect the electrochemical properties.
Spin/parity of Higgs-like particle at D0
Creators: name: Tuchming, Boris
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present prospects for tests of different spin and parity hypotheses for a particle $H$ of mass 125 GeV produced in association with a vector boson and decaying into a pair of b-quarks. We use the combined analysis of the WH->lvbb, ZH->llbb, and ZH-> vvbb channels based on the full Run II dataset collected at $\sqrt s=1.96$ TeV with the \dzero\ detector at the Fermilab Tevatron collider.
description: 4 pages, 8 figures. Contribution to the proceedings of LHCP-2013, Barcelona, Spain, May 13-18th, 2013
Deutetrabenazine in Tics Associated with Tourette Syndrome
Creators: name: Jankovic, Joseph
name: Jimenez-Shahed, Joohi
name: Budman, Cathy
name: Coffey, Barbara
name: Murphy, Tanya
name: Shprecher, David
name: Stamler, David
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Tic disorders
subject: Movement disorders
subject: Movement disorders--Treatment
subject: Tourette syndrome
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Background: Deutetrabenazine, an inhibitor of vesicular monoamine transporter type 2 (VMAT2) depletes presynaptic dopamine and is useful in the treatment of hyperkinetic movement disorders. This study explored the safety, tolerability, and preliminary efficacy of deutetrabenazine in adolescents with moderate-to-severe tics associated with Tourette syndrome (TS).

Methods: In this open-label study of 12–18-year-old patients with TS-related tics, deutetrabenazine was titrated up to 36 mg/day over 6 weeks to adequately suppress tics without bothersome adverse effects (AEs), followed by maintenance at optimal dose for 2 weeks. An independent blinded rater assessed tic severity using the Yale Global Tic Severity Scale (YGTSS), which was the primary outcome measure. Secondary outcome measures included the TS Clinical Global Impression (TS-CGI) and TS Patient Global Impression of Change (TS-PGIC).

Results: Twenty-three enrolled patients received deutetrabenazine and had at least 1 post-baseline YGTSS assessment. The mean (SD [standard deviation]) baseline YGTSS Total Tic Severity Score (TTS) was 31.6 (7.9) and had decreased by 11.6 (8.2) points at week 8, a 37.6% reduction in tic severity (p<0.0001). The TS-CGI score improved by 1.2 (0.81) points (p<0.0001) and the TS-PGIC results at week 8 indicated that 76% of patients were much improved or very much improved compared with baseline. The mean (SD) daily deutetrabenazine dose at week 8 was 32.1 (6.6) mg (range 18–36 mg). One week after withdrawal of deutetrabenazine, the TTS scores increased by 5.6 (8.4) points, providing confirmation of the drug effect. No serious or severe adverse events were reported.

Discussion: The results of this open-label 8-week study suggest that deutetrabenazine is safe and associated with improvement in tic severity in adolescents with TS and troublesome tics.
Kinetic and docking study of synthesis of glyceryl monostearate by immobilized lipase in non-aqueous media
Creators: name: Jawale, Priyanka V.
name: Bhanage, Bhalchandra M.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Glyceryl monostearate is extensively used as an emulsifier in many industries. Mono acylation of glycerol was carried out by utilizing immobilized Candida antarctica lipase B (Cal B) as a biocatalyst and vinyl stearate as an acyl donor. Different reaction parameters, such as selection of lipases from various sources (like Candida antarctica, Candida rugosa, and Mucor meihei) and their quantity, shaking speed, temperature, substrate concentration, and reusability were studied in detail to achieve excellent conversion. Overall, 98% conversion of glycerol was obtained at a mole ratio of 1:1 of glycerol to vinyl stearate, using 12 mg of immobilized Cal B at 45 °C for 3 h. The mechanism of the given reaction was anticipated based on the results of the Lineweaver-Burk plots. It was found that the reaction followed the Ping-Pong Bi Bi mechanism with inhibition of glycerol. As it was a kinetically controlled synthesis, different kinetic constants were estimated by non-linear regression analysis. The activation energy for Cal B was found to be 10.3 kcal/mol. Further, biocatalyst can be reused up to four catalytic cycles with an average four percent loss of activity. A molecular docking study was done to find out the confirmation of substrates and their binding positions in an enzyme. It was noticed that the reaction proceeds through acyl-enzyme complex formation followed by the transfer of that acyl group to another substrate.
Probing superheavy dark matter through lunar radio observations of ultrahigh-energy neutrinos and the impacts of neutrino cascades
Creators: name: Das, Saikat
name: Carpio, Jose Alonso
name: Murase, Kohta
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Ultrahigh-energy neutrinos (UHE$ν$s) can be used as a valuable probe of superheavy dark matter above $\sim 10^9$ GeV, the latter being difficult to probe with collider and direct detection experiments due to the feebly interacting nature. Searching for radio emissions originating from the interaction of UHE$ν$s with the lunar regolith enables us to explore energies beyond $10^{12}$ GeV, which astrophysical accelerators cannot achieve. Taking into account the interaction of UHE$ν$s with the cosmic neutrino background and resulting standard neutrino cascades to calculate the neutrino flux on Earth, for the first time, we investigate sensitivities of such lunar radio observations to very heavy dark matter. We also examine the impacts of cosmogenic neutrinos that have the astrophysical origin. We show that the proposed ultra-long wavelength lunar radio telescope, as well as the existing low-frequency array, can provide the most stringent constraints on decaying or annihilating superheavy dark matter with masses at $\gtrsim 10^{12}$ GeV. The limits are complementary to or even stronger than those from other UHE$ν$ detectors, such as the IceCube-Gen2 radio array and GRAND.
description: 18 pages, 7 figures
In Situ Transmission X-Ray Microscopy of the Lead Sulfate Film Formation on Lead in Sulfuric Acid
Creators: name: Knehr, K. W.
name: Eng, Christopher
name: Chen-Wiegart, Yu-Chen Karen
name: Wang, Jun
name: West, Alan C.
Publisher: name: Columbia University
Year: 2015
Subjects: subject: X-ray microscopy
subject: Sulfates
subject: Lead compounds
subject: Electrochemistry
subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Electrical engineering

description: Transmission X-ray microscopy is utilized to monitor, in real time, the behavior of the PbSO4 film that is formed on Pb in H2SO4. Images collected from the synchrotron x-rays are coupled with voltammetric data to study the initial formation, the resulting passivation, and the subsequent reduction of the film. It is concluded with support from quartz-crystal-microbalance experiments that the initial formation of PbSO4 crystals occurs as a result of acidic corrosion. In addition, the film is shown to coalesce during the early stages of galvanostatic oxidation and to passivate as a result of morphological changes in the existing film. Finally, it is observed that the passivation process results in the formation of large PbSO4 crystals with low area-to-volume ratios, which are difficult to reduce under both galvanostatic and potentiostatic conditions.
Detector and Event Visualization with SketchUp at the CMS Experiment
Creators: name: Sakuma, Tai
name: McCauley, Thomas
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We have created 3D models of the CMS detector and particle collision events in SketchUp, a 3D modelling program. SketchUp provides a Ruby API which we use to interface with the CMS Detector Description to create 3D models of the CMS detector. With the Ruby API, we also have created an interface to the JSON-based event format used for the iSpy event display to create 3D models of CMS events. These models have many applications related to 3D representation of the CMS detector and events. Figures produced based on these models were used in conference presentations, journal publications, technical design reports for the detector upgrades, art projects, outreach programs, and other presentations.
description: 5 pages, 6 figures, Proceedings for CHEP 2013, 20th International Conference on Computing in High Energy and Nuclear Physics
Chinchilla Bennett 1829
Creators: name: Woods, Charles A.
Publisher: name: Zenodo
Year: 1993
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Chinchillidae
Chinchilla

description: Chinchilla Bennett, 1829. Gard. Menag. Zool. Soc., 1:1. TYPE SPECIES: Mus laniger Molina, 1782.
description: Published as part of Charles A. Woods, 1993, Order Rodentia - Suborder Hystricognathi, pp. 771-806 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 777, DOI: 10.5281/zenodo.7353083
description: {"references": ["Molina, G. I. 1782. Saggio sulla storia naturale del Chili. Stamperia di S. Tommaso d'Aquino, Bologna."]}
Galvanostatic Intermittent Titration Study of the Positive Electrode of a Na|Ni(Fe)-Chloride Cell
Creators: name: Zhu, Ruixing
name: Vallance, Michael
name: Rahimian, Saeed Khaleghi
name: West, Alan C.
Publisher: name: Columbia University
Year: 2015
Subjects: subject: Volumetric analysis
subject: Electric batteries
subject: Chlorides
subject: Electrochemistry
subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Electrical engineering

description: The response to open-circuit interrupts of porous mixed iron-nickel cathodes operating in NaCl-buffered, molten NaAlCl4 electrolyte has been characterized as a function of state of charge (SOC) for different iron loadings and different charge and discharge rates. After discharge, the open-circuit potential (OCP) can evolve in time from the iron plateau to the nickel plateau, and this behavior can be explained by galvanic interactions between iron metal and Ni2+. Characteristic times of the OCP transients depend on SOC and can be large. When the OCP has converged on a steady state during discharge, its value may provide an estimate of the mole fraction of NiCl2 at the interface of the triclinic (Ni,Fe)Cl2 film that resulted from metal oxidation. Detailed analyses of the experiment require modeling of the galvanic conversion rates, which depend on both charge-transfer and mass-transfer phenomena.
Hospital volume–outcome relationship in total knee arthroplasty: a systematic review and dose–response meta-analysis
Creators: name: Kugler, Charlotte M.
name: Goossen, K.
name: Rombey, T.
name: De Santis, K. K.
name: Mathes, T.
name: Breuing, J.
name: Hess, S.
name: Burchard, R.
name: Pieper, D.
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
subject: total knee arthroplasty
subject: knee osteoarthritis
subject: hospital volume
subject: hospital volume–outcome relationship
subject: systematic review
subject: dose–response meta-analysis

description: Purpose: This systematic review and dose–response meta-analysis aimed to investigate the relationship between hospital volume and outcomes for total knee arthroplasty (TKA). Methods: MEDLINE, Embase, CENTRAL and CINAHL were searched up to February 2020 for randomised controlled trials and cohort studies that reported TKA performed in hospitals with at least two different volumes and any associated patient-relevant outcomes. The adjusted effect estimates (odds ratios, OR) were pooled using a random-effects, linear dose–response meta-analysis. Heterogeneity was quantified using the I2-statistic. ROBINS-I and the GRADE approach were used to assess the risk of bias and the confidence in the cumulative evidence, respectively. Results: A total of 68 cohort studies with data from 1985 to 2018 were included. The risk of bias for all outcomes ranged from moderate to critical. Higher hospital volume may be associated with a lower rate of early revision ≤ 12 months (narrative synthesis of k = 7 studies, n = 301,378 patients) and is likely associated with lower mortality ≤ 3 months (OR = 0.91 per additional 50 TKAs/year, 95% confidence interval [0.87–0.95], k = 9, n = 2,638,996, I2 = 51%) and readmissions ≤ 3 months (OR = 0.98 [0.97–0.99], k = 3, n = 830,381, I2 = 44%). Hospital volume may not be associated with the rates of deep infections within 1–4 years, late revision (1–10 years) or adverse events ≤ 3 months. The confidence in the cumulative evidence was moderate for mortality and readmission rates; low for early revision rates; and very low for deep infection, late revision and adverse event rates. Conclusion: An inverse volume–outcome relationship probably exists for some TKA outcomes, including mortality and readmissions, and may exist for early revisions. Small reductions in unfavourable outcomes may be clinically relevant at the population level, supporting centralisation of TKA to high-volume hospitals.
Degradation of selected pharmaceuticals detected in wastewater systems using an enzyme-mediator system and identification of resulting transformation products
Creators: name: Caraene, Ionut Daniel
name: Gruchlik, Yolanta
name: Busetti, Francesco
name: Linge, Kathryn L.
name: Joll, Cynthia A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Pharmaceuticals are often found in municipal wastewater due to human excretion and disposal of drugs into sewerage systems. Conventional wastewater treatment plants were not designed for pharmaceutical removal and, hence, pharmaceutical concentrations ranging from ng L−1 to μg L−1 are often detected in treated wastewater, with additional treatment required for full removal. This study has investigated the potential of Trametes versicolour laccase enzyme and 2,2'-azino-bis-(3-ethyl-benzthiazoline-6-sulphonic acid) diammonium salt (ABTS) mediator system to degrade sulfamethoxazole, trimethoprim, metronidazole and phenytoin. The best degradation was observed at pH 5 for both sulfamethoxazole (97% in 12 hours) and trimethoprim (44% in 168 hours), using an initial micropollutant concentration of 100 µM, an enzymatic activity between 110–115 U L−1, and an ABTS concentration of 200 µM. Phenytoin and metronidazole were not degraded. Deamination followed by hydroxylation led to the formation of the two major sulfamethoxazole transformation products (TPs), whilst hydroxylation and hydroxylation/demethylation mechanisms formed the majority of the trimethoprim TPs. The sulfamethoxazole and trimethoprim TPs observed from the laccase-ABTS system were similar to the TPs obtained from degradation processes such as advanced oxidation or photodegradation. The laccase-ABTS system shows promise for control of emerging contaminants containing electron donating groups (such as amines and methoxy groups) on aromatic rings in wastewater systems.
Three-dimensional simulations of near-surface convection in main-sequence stars - I. Overall structure
Creators: name: Beeck, Benjamin
name: Cameron, Robert H.
name: Reiners, Ansgar
name: Schüssler, Manfred
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The near-surface layers of cool main-sequence stars are structured by convective flows, which are overshooting into the atmosphere. The flows and the associated spatio-temporal variations of density and temperature affect spectral line profiles and thus have an impact on estimates of stellar properties such as effective temperature, gravitational acceleration, and abundances. We aim at identifying distinctive properties of the thermodynamic structure of the atmospheres of different stars and understand their causes. We ran comprehensive 3D radiation hydrodynamics simulations of the near-surface layers of six simulated stars of spectral type F3V to M2V with the MURaM code. We carry out a systematic parameter study of the mean stratifications, flow structures, and the energy flux in these stars.\par Results: We find monotonic trends along the lower main sequence in granule size, flow velocity, and intensity contrast. The convection in the M-star models differs substantially from that of the hotter stars, mainly owing to the more gradual transition from convective to radiative energy transport. While the basic mechanisms driving surface convection in cool stars are the same, the properties of the convection vary along the main sequence. Apart from monotonic trends in rms velocity, intensity contrast, granule size, etc., there is a transition between "naked" and "hidden" granulation around spectral type K5V caused by the (highly non-linear) temperature dependence of the opacity. These variations have to be taken into account when stellar parameters are derived from spectra.
description: 14 pages, 1 appendix, 15+2 figures, 2 tables; accepted for publication in A&A
Hydrogen Production with a Simple and Scalable Membraneless Electrolyzer
Creators: name: O'Neil, Glen D.
name: Christian, Corey D.
name: Brown, David Emory
name: Esposito, Daniel
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Three-dimensional printing
subject: Water--Electrolysis
subject: Electrolytic cells
subject: Chemical engineering
subject: FOS: Chemical engineering
subject: Electrical engineering

description: Ion-conducting membranes are essential components in many electrochemical devices, but they often add substantial cost, limit performance, and are susceptible to degradation. This work investigates membraneless electrochemical flow cells for hydrogen production from water electrolysis that are based on angled mesh flow-through electrodes. These devices can be fabricated with as few as three parts (anode, cathode, and cell body), reflecting their simplicity and potential for low-cost manufacture. 3D printing was used to fabricate prototype electrolyzers that were demonstrated to be electrolyte agnostic, modular, and capable of operating with minimal product crossover. Prototype electrolyzers operating in acidic and alkaline solutions achieved electrolysis efficiencies of 61.9% and 72.5%, respectively, (based on the higher heating value of H2) when operated at 100 mA cm−2. Product crossover was investigated using in situ electrochemical sensors, in situ imaging, and by gas chromatography (GC). GC analysis found that 2.8% of the H2 crossed over from the cathode to the anode stream under electrolysis at 100 mA cm−2 and fluid velocity of 26.5 cm s−1. Additionally, modularity was demonstrated with a three-cell stack, and high-speed video measurements tracking bubble evolution from electrode surfaces provide valuable insight for the further optimization of electrolyzer design and performance.
Chinchilla brevicaudata Waterhouse 1848
Creators: name: Woods, Charles A.
Publisher: name: Zenodo
Year: 1993
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Chinchillidae
Chinchilla
Chinchilla brevicaudata

description: Chinchilla brevicaudata Waterhouse, 1848. Nat. Hist. Mamm., 2:241. TYPE LOCALITY: Peru. DISTRIBUTION: Andes of S Bolivia, S Peru, NW Argentina, and Chile. STATUS: CITES - Appendix I (South American populations only); U.S. ESA - Endangered as C. b. boliviano; IUCN - Indeterminate. SYNONYMS: boliviano; chinchilla (Lichtenstein, 1830), intermedia, major. COMMENTS: Pine et al. (1979:362-363) included brevicaudata in lanigera without comment.
description: Published as part of Charles A. Woods, 1993, Order Rodentia - Suborder Hystricognathi, pp. 771-806 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 777, DOI: 10.5281/zenodo.7353083
description: {"references": ["Pine, R. H., S. D. Miller, and M. L. Schamberger. 1979. Contributions to the mammalogy of Chile. Mammalia, 43: 339 - 376."]}
Additional file 1 of Physical Activity During Lockdowns Associated with the COVID-19 Pandemic: A Systematic Review and Multilevel Meta-analysis of 173 Studies with 320,636 Participants
Creators: name: Wilke, Jan
name: Rahlf, Anna Lina
name: Füzéki, Eszter
name: Groneberg, David A.
name: Hespanhol, Luiz
name: Mai, Patrick
name: de Oliveira, Gabriela Martins
name: Robbin, Johanna
name: Tan, Benedict
name: Willwacher, Steffen
name: Hollander, Karsten
name: Pillay, Julian David
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Table S1. Checklist for study risk of bias assessment (adapted from Downs & Black). Table S2. Characteristics of the included studies. Age is reported as mean ± SD or range (youngest-oldest age) or median (single value). We listed eligible criteria if none of these metrics were reported (e.g., >, < age). Table S3. Reference list of included studies. Table S4. Ratings of study risk of bias (adapted Downs & Black checklist).
A branching process model for dormancy and seed banks in randomly fluctuating environments
Creators: name: Blath, Jochen
name: Hermann, Felix
name: Slowik, Martin
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
subject: dormancy
subject: persistence
subject: Bienaymé–Galton–Watson process
subject: branching process
subject: seed bank
subject: fitness

description: The goal of this article is to contribute towards the conceptual and quantitative understanding of the evolutionary benefits for (microbial) populations to maintain a seed bank consisting of dormant individuals when facing fluctuating environmental conditions. To this end, we discuss a class of ‘2-type’ branching processes describing populations of individuals that may switch between ‘active’ and ‘dormant’ states in a random environment oscillating between a ‘healthy’ and a ‘harsh’ state. We incorporate different switching strategies and suggest a method of ‘fair comparison’ to incorporate potentially varying reproductive costs. We then use this concept to compare the fitness of the different strategies in terms of maximal Lyapunov exponents. This gives rise to a ‘fitness map’ depicting the environmental regimes where certain switching strategies are uniquely supercritical.
Tevatron Higgs results
Creators: name: Tuchming, Boris
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the combination of searches for the Standard Model Higgs boson, using up to 10 \invfb\ of $p\bar p$ collisions at $\sqrts$=1.96 TeV collected with the CDF and \dzero\ detectors at the Fermilab Tevatron collider. The major contributing channels are optimized for the main production modes, the associated production with a vector boson ($VH$, with $V=W,Z$), the vector boson fusion, and the gluon-gluon fusion, and the different decay modes $H\to b\bar b$, $H\toτ^+τ^-$, $H\to W^+W^-$, and $H\to γγ$. A significant excess of events is observed in the mass range $115
description: 6 pages, 14 figures. Contribution to the proceedings of LHCP-2013, Barcelona, Spain, May 13-18th, 2013