cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gli arbitrati delineati dal "collegato lavoro " e prime attuazioni.
Creators: name: Arrigoni, Caterina
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2011
Subjects: IUS/15 Diritto processuale civile

description: L’autore analizza la disciplina del c.d. «collegato lavoro», che ha mostrato un’apertura nei confronti della soluzione alternativa delle liti in materia laburistica, ridisegnando l’arbitrato e scorporandolo in quattro diverse figure. Alle garanzie poste a tutela del lavoratore nella stipulazione della clausola compromissoria, a lite insorta fa da contraltare la non necessarietà dalla previa opzione superindividuale in favore dell’arbitrato.
Dopo aver analizzato la natura dell’istituto, che il legislatore, sulla scia della tradizione, denomina libero, ma regolamenta in modo addirittura più puntuale rispetto a quello rituale, prende in considerazione la disciplina specifica fino ad arrivare all’efficacia del lodo ed anche all’analisi delle prime applicazioni pratiche.
WORK OF RUSSIAN LOCAL SCHOOLS IN TURKESTAN.
Creators: name: Xasanova, Sadoqat
name: Mamatova, Mahfuza
Publisher: name: Zenodo
Year: 2023

description: This article talks about the influence of the Russification policy of the Russian Empire on the activities of schools in the Turkestan region, the organization of schools in the Russian system and the education system in these schools.
Activity regimes inferred from automatic classification of volcanic tremor at Mt. Etna, Italy
Creators: name: Masotti, Matteo
name: Falsaperla, Susanna
name: Langer, Horst
name: Spampinato, Salvatore
name: Campanini, Renato
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2007
Subjects: FIS/06 Fisica per il sistema terra e il mezzo circumterrestre

description: A renewal of eruptive activity at Mt Etna started from the Southeast Crater on 14 July
2006, about 16 months after the end of the last effusive episode. This new eruption
reiterated the importance of continuous volcanic monitoring as well as the need of automatic
processing and classification of those signals which might be used to disclose
such impending eruptive stages. Among seismic signals, volcanic tremor - the persistent
background radiation continuously recorded on open conduit, basaltic volcanoes
like Mt Etna - is of utmost importance for the identification of different regimes of volcanic
activity. Indeed, changes in amplitude and frequency content of volcanic tremor
usually herald the unrest of the volcano. The application of the Support Vector Machine
classifier to spectrograms of volcanic tremor was carried out on data recorded
at Mt Etna in 2001, in a time span of 46 days encompassing episodes of lava fountains
and effusive activity. Moving on from the positive results obtained from this
automatic classification - with less than 6% of misclassifications - we propose a new
application using tools with supervised (Artificial Neural Networks, Support Vector
Machine) and unsupervised (Cluster Analysis) learning to the new data set recorded
in July 2006. In doing so, we discuss issues such as data transformations for the definition
of the patterns, learning and testing strategies as well as the optimization of the
classifier configuration (e.g., trial and error, Genetic Algorithms). The performance
of each method is analyzed and discussed in terms of identification of the different
states of the volcano. Finally, we carry out a careful a-posteriori analysis of the misclassifications,
devoting particular attention to their temporal distribution and relation
to transitional states of volcanic activity.
The special linear version of the projective bundle theorem
Creators: name: Ananyevskiy, Alexey
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics
subject: 14F42, 19G12, 19G99

description: A special linear Grassmann variety SGr(k,n) is the complement to the zero section of the determinant of the tautological vector bundle over Gr(k,n). For a representable ring cohomology theory A(-) with a special linear orientation and invertible stable Hopf map η, including Witt groups and MSL[η^{-1}], we have A(SGr(2,2n+1))=A(pt)[e]/(e^{2n}), and A(SGr(2,2n)) is a truncated polynomial algebra in two variables over A(pt). A splitting principle for such theories is established. We use the computations for the special linear Grassmann varieties to calculate A(BSL_n) in terms of the homogeneous power series in certain characteristic classes of the tautological bundle.
description: Some misprints corrected, slightly revised notation
Bioinformatics tools for mass spectrometry, phylogenetic footprinting, and the integration of biological data - [kumulative Dissertation]
Creators: name: Treutler, Hendrik
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 004
subject: 570

description: Diese kumulative Dissertation wurde in Englisch verfasst und beinhaltet sechs Publikationen aus dem Gebiet der Bioinformatik. Das Oberziel dieser Publikationen ist ein Verständnis von biologischen Prozessen auf dem Niveau der Systembiologie zu ermöglichen. Hierzu werden unterschiedliche bioinformatische Softwarewerkzeuge quelloffen und frei verfügbar bereitgestellt. Die sechs Publikationen fallen in die drei Bioinformatik-Teilgebiete (i) “Phylogenetic footprinting”, (ii) “Data Processing and Interpretation of Mass Spectrometry Data” und (iii) “Integration of biological data”. Im Teilgebiet (i) wird die präzise Vorhersage und der objektive Vergleich von Transkriptionsfaktorbindestellen-Motiven behandelt. Im Teilgebiet (ii) wird die Extraktion von Metaboliten-Signalen aus Massenspektrometriedaten und die Auswertung dieser auf dem Level von Metabolitenfamilien behandelt. Im Teilgebiet (iii) wird das Softwarewerkzeug VANTED weiterentwickelt.
description: This cumulative dissertation is wridden in english and includes six papers from the bioinformatics area. The aim of these papers is an unterstanding of biological processes on the systems biology level. For this purpose I published different open-source, freely available software tools.The six publications are rooted in the three bioinformatics fields (i) “Phylogenetic footprinting”, (ii) “Data Processing and Interpretation of Mass Spectrometry Data”, and (iii) the “Integration of biological data”. In field (i) the precise prediction and objective comparison of transcription factor binding motifs is covered. In field (ii) the extraction of metabolite signals from mass spectrometry data and the analysis of these on the level of metabolite families is covered. In field (iii) the software tools VANTED is developed further.
A first estimate of radio halo statistics from large-scale cosmological simulation
Creators: name: Sutter, P. M.
name: Ricker, P. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a first estimate based on a cosmological gasdynamics simulation of galaxy cluster radio halo counts to be expected in forthcoming low-frequency radio surveys. Our estimate is based on a FLASH simulation of the LCDM model for which we have assigned radio power to clusters via a model that relates radio emissivity to cluster magnetic field strength, intracluster turbulence, and density. We vary several free parameters of this model and find that radio halo number counts vary by up to a factor of two for average magnetic fields ranging from 0.2 to 3.1 uG. However, we predict significantly fewer low-frequency radio halos than expected from previous semi-analytic estimates, although this discrepancy could be explained by frequency-dependent radio halo probabilities as predicted in reacceleration models. We find that upcoming surveys will have difficulty in distinguishing models because of large uncertainties and low number counts. Additionally, according to our modeling we find that expected number counts can be degenerate with both reacceleration and hadronic secondary models of cosmic ray generation. We find that relations between radio power and mass and X-ray luminosity may be used to distinguish models, and by building mock radio sky maps we demonstrate that surveys such as LOFAR may have sufficient resolution and sensitivity to break this model degeneracy by imaging many individual clusters.
description: 18 pages, 14 figures, revised from referee comments, ApJ accepted, public catalog available at http://sipapu.astro.illinois.edu/http://sipapu.astro.illinois.edu/foswiki/bin/view/Main/RadioHaloMaps
title: Literatura, humanismo y guerra: La crítica en la edad ateniense de Alfonso Reyes
Creators: name: Ugalde Quintana, Sergio
Publisher: name: Iberoamericana/Vervuert
Year: 2021
Subjects: subject: 860

description: Bibliotheca Ibero-Americana, vol. 185Políticas y estrategias de la crítica, II: ideología, historia y actores de los estudios literarios, p. 141
Der Liedersammler Albert Brosch - Leben und Werk
Creators: name: Behn, Claudia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2018
Subjects: subject: Volksmusik
subject: Brosch
subject: Volkslied
subject: Sammler
subject: Musikalische Analyse
subject: 780

description: Im Zentrum der Dissertation steht das Leben des Liedersammlers Albert Brosch (1886-1970) und seine 18951 Lieder und Reime umfassende Liedersammlung (Böhmerwald, Egerlandes, Auslandsdeutsche, Mittelfranken). Ziele: Eine umfassende Gesamtdarstellung von Albert Broschs Leben und Werk. Methoden: Interviews, die musikalische, textliche und inhaltliche Analyse der Liedersammlung, Quellenstudien, Archivstudien sowie Quellenanalysen der Liedersammlung. Ergebnisse: Detaillierte Informationen zum Leben des Volksliedsammlers Albert Brosch (Lebensstationen, Ehrungen, Korrespondenz, Nachlass) sowie zum Werk (Sammlungstätigkeit, Aufrufe, Vorgehensweise, Forschungsmethode, Aufbau, Schwerpunkte, Analyse, Ergebnisse, Nachwirkungen).
description: The focus of the dissertation is the life oft the song collector Albert Brosch (1886-1970) and his 18 951 songs and rhymes comprehensive song collection (Böhmerwald, Egerland, Auslandsdeutsche, Mittelfranken). Aims: a comprehensive overall presentation of Albert Broschs life and work. Methods: interviews, the musical, textual and content analysis of the song collection, source studies, archival studies and source of the song collection; folk song. Results: detailed information about the life of the folk collector Albert Brosch (life stations, honors, Correspondence, Estate), as well as to the work (Collection activity, calls, approach, research method, structure, priorities, analysis, results, after-effects).
Supervised and unsupervised automatic classification methods applied to volcanic tremor data at Mt Etna, Italy
Creators: name: Masotti, Matteo
name: Falsaperla, Susanna
name: Langer, Horst
name: Spampinato, Salvatore
name: Campanini, Renato
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2006
Subjects: FIS/06 Fisica per il sistema terra e il mezzo circumterrestre

description: Continuous seismic monitoring has achieved a key position in monitoring active volcanoes. However, it comes with the problem of a huge quantity of data difficult to handle. Automatic pattern recognition techniques have proven effective in seismic data processing and, consequently, have been increasingly implemented to solve different tasks. In this paper we investigate the development of the characteristics of the seismic signal on Mt Etna and its relation to regimes of volcanic activity. To this purpose we apply classification methods both with supervisor (Artificial Neural Networks, Support Vector Machine) and without supervisor (cluster analysis). The former "learn" from exemplar patterns, inferring rules to deal with new and/or noisy data to classify, whereas the latter seek for heterogeneities in the data set applying a specific metric. The choice of automatic classification methods is determined by the necessity to solve rather complex discrimination problems using as little a-priori information as possible. We focus on volcanic tremor recordings at Mt Etna in 2001, a time span where there is a wide variety of feature signals, encompassing periods of pre- and post-eruptive quiescence, episodes of lava fountains, and a 23 day-long effusive activity. We establish four target classes, i.e., pre-eruptive, lava fountains, eruptive, and post-eruptive. The a-priori information used for the classification with supervisor is based on volcanological reports, and therefore it does not directly depend on the characteristics of the seismic signal. We discuss performance and characteristics of the different techniques in light of an implementation to automatically analyze seismic data and reduce volcanic hazard.
Rainbow flags and body bags : violence, terror, pride and everyday resistance in Northeastern Mexico
Creators: name: Pysklywec, John Alexander
Publisher: name: University of British Columbia
Year: 2014

description: In 2006, Mexico’s then president, Felipe Calderón, declared a war on organized crime, popularly referred to now as a ‘drug war’, that has resulted in the deaths and disappearances of hundreds-of-thousands of people. In spite of this ongoing hardship and tragedy, in 2012 and 2013, the Northeastern border city of Esperanza (pseudonym) bore witness to the region’s first pride march. Why now? Why, in this moment of violence and conflict throughout the city and the region, have members of gender and sexual minority (GSM) communities in Esperanza decided to march for rights and recognition? What does this say about pride and other forms of GSM activisms in spaces of violent conflict? In this thesis, as I explore these questions, I recount a story about resistance and celebration of GSM life in the US/Mexico borderlands in a time of increasing fear, militarization, and death. The central argument I make here is that pride, as a form of activism and resistance, is variegated across space and time. That is, pride comes to mean different things in different places, and in those different places, it does different things. I demonstrate this by mounting three supporting arguments. First, I assert that state-directed violence has been a catalyst for GSM activism in Mexico in the past. I argue that the emergence of GSM activisms is rooted in times of violence and crisis that, like today in Esperanza, are not specifically directed at GSM communities, but more broadly within Mexican society. Next, I frame the contemporary violence in Mexico as a form of terror perpetrated by powerful state and non-state actors. Through the use of interviewee narratives and my own experiences, I argue that life in Esperanza is being shattered by violence and terror. This shattering is both heart-wrenching and destructive, but is also potentially creative of the conditions for challenging the status quo and societal norms. Finally, I argue that in the violent spaces of Esperanza, GSM activisms are challenging hetero/cis-normativity and oppression, but they also become acts of everyday resistance and contestation of the violence and terror of the so-called ‘drug war’.
A Non-Mainstream Viewpoint on Apparent Superluminal Phenomena in AGN Jet
Creators: name: Liu, Wen-Po
name: Liu, Li-Yan
name: Wang, Chun-Cheng
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The group velocity of light in material around the AGN jet is acquiescently one (c as a unit), but this is only a hypothesis. Here, we re-derive apparent superluminal and Doppler formulas for the general case (it is assumed that the group velocity of light in the uniform and isotropic medium around a jet (a beaming model) is not necessarily equal to one, e.g., Araudo et al. (2010) thought that there may be dense clouds around AGN jet base), and show that the group velocity of light close to one could seriously affect apparent superluminal phenomena and Doppler effect in the AGN jet (when the viewing angle and Lorentz factor take some appropriate values).
description: 4 pages, 2 figures, new version accepted for publication in Journal of Astrophysics and Astronomy
Zur Bewertung der Ergebnisqualität im ambulanten Koronarsport - ausgewählte Ergebnisse der RASCAD-Studie
Creators: name: Dürrenfeld, Kati
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2011
Subjects: subject: Koronare Herzkrankheit
subject: Rehabilitation
subject: Behindertensport
subject: Online-Publikation
subject: Hochschulschrift
subject: 790

description: Der ambulante Koronarsport stellt einen essentiellen Bestandteil einer langfristig ausgerichteten Versorgung von Patienten mit kardiovaskulären Erkrankungen dar. Die vorliegende Dissertation berichtet über Teilergebnisse eines gemeinschaftlichen Forschungsprojektes namens RASCAD. Ziel dieses Projektes ist es, einen wesentlichen Beitrag zu Bewertung der Ergebnisqualität des ambulanten Koronarsports zu leisten. Mittels einer umfangreichen Diagnostik wird die Erreichung funktional-motorischer, psychosozialer und edukativer Ziele beurteilt. An der Studie mit einem Untersuchungszeitraum von einem Jahr nahmen 70 Probanden teil, wobei 51 der Versuchsgruppe (17 Einsteiger, 34 Fortgeschrittene) und 19 der Kontrollgruppe zugeordnet waren. Im Hauptergebnis zeigt sich, dass die Versuchsgegenüber der Kontrollgruppe Verbesserungen der Funktionsfähigkeit im Bereich der Bauch- und Hüftbeugemuskulatur aufweist. In beiden Gruppen konnte eine Steigerung der Ausdauer, eine verringerte Selbsteinschätzung erkrankungsbedingter Behinderungen sowie eine verbesserte soziale Unterstützung nachgewiesen werden.
On Disturbance State-Space Models and the Particle Marginal Metropolis-Hastings Sampler
Creators: name: Murray, Lawrence M.
name: Jones, Emlyn M.
name: Parslow, John
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: We investigate nonlinear state-space models without a closed-form transition density, and propose reformulating such models over their latent noise variables rather than their latent state variables. In doing so the tractable noise density emerges in place of the intractable transition density. For importance sampling methods such as the auxiliary particle filter, this enables importance weights to be computed where they could not be otherwise. As case studies we take two multivariate marine biogeochemical models and perform state and parameter estimation using the particle marginal Metropolis-Hastings sampler. For the particle filter within this sampler, we compare several proposal strategies over noise variables, all based on lookaheads with the unscented Kalman filter. These strategies are compared using conventional means for assessing Metropolis-Hastings efficiency, as well as with a novel metric called the conditional acceptance rate for assessing the consequences of using an estimated, and not exact, likelihood. Results indicate the utility of reformulating the model over noise variables, particularly for fast-mixing process models.
Die Konstruktion einer artifiziellen Oxidoreduktase - Implementierung des CXXC-Tetrapeptids in das Strukturprotein M7
Creators: name: Voigtmann, Martin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2018
Subjects: subject: 572

description: Die CXXC-Oxidoreduktasen steuern eine Vielzahl zellulärer Redoxprozesse. Dabei ist unklar, wie deren Proteinstruktur die beobachtbare Aktivitätsbreite erzeugt. Ziel der Arbeit war es durch den Transfer des CXXC-Tetrapeptidmotivs in das artifizielle Protein M7 neue Erkenntnisse über die Struktur-Funktionsbeziehung dieser Oxidoreduktasen zu erhalten. Die Implementierung der active site Cys-X-X-Cys-Sequenz, aus Thioredoxin und DsbA, erzeugte im M7 ein nukleophiles Cystein dessen Aktivität mit der M7-Struktur gekoppelt ist. Dabei zeigten M7-Redoxvarianten in thermodynamischen (Redoxpotential und Cystein pKa) und kinetischen Assays (Redoxkinetik) signifikante Unterschiede zu den Kontroll-CXXC-Peptiden. Hierbei ist die Redoxaktivität mit der M7-Struktur komplexer verknüpft als in den natürlichen Oxidoreduktasen. Diese Arbeit stellt den initialen Designzyklus zur Generierung von redoxaktiven M7-Varianten dar.
description: The CXXC-oxidoreductases perform a range of cellular redox processes. However it is still unknown, how these enzymes generate their huge functional diversity, despite minimal structural differences. The transfer of the CXXC sequence into the artificial protein M7 can illuminate the relationship between structure and function of these oxidoreductases. Aim of this work was the design of a redox active M7. The implementation of the thioredoxin and DsbA tetrapeptid motif (Cys-X-X-Cys) into M7 generated a structure dependent nucleophilic cysteine. In thermodynamic (cysteine E° and pKa) and kinetic assays (redox kinetic) M7 redox variants showed significant activities compared to control CXXC-peptides. For all M7 redox variants, the redox activity is stronger convoluted with the structure than in natural oxidoreductases. Here the stability of the native oxidized state appears as the key regulator. This work represents the successful initial design round to construct redox active M7 variants.
In-Vitro-Rekonstitution des 3‘-Prozessierungsfaktors CPSF (cleavage and polyadenylation specificity factor)
Creators: name: Schönemann, Lars Frederic
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 572

description: Mit nur wenigen Ausnahmen werden alle messengerRNAs (mRNAs) kotranskriptional modifiziert. Eine dieser Modifikationen stellt die Spaltung und Polyadenylierung am 3‘-Ende der Prä-mRNAs dar. Der gebildete Poly(A)-Schwanz bestimmt durch Auswirkungen auf die Stabilität sowie die Effizienz von mRNA-Export und Translation maßgeblich das Schicksal einer jeder gebildeten mRNA. Obwohl der Prozess der Prä-mRNA-3‘-Prozessierung bereits seit über dreißig Jahren intensiv untersucht wird, ist es bislang nicht gelungen die Reaktionen von Spaltung und Polyadenylierung mit ausschließlich rekombinanten Proteinen in vitro ablaufen zu lassen.In dieser Arbeit wurde der zweite Reaktionsschritt der 3‘-Prozessierung, die Polyadenylierung, in vitro rekonstituiert und so die minimale Zusammensetzung an essentiellen Faktoren für die Katalyse dieses Schrittes der Prä-mRNA-3‘-Prozessierung identifiziert. Weiterhin wurden vielversprechende Vorversuche zur In-Vitro-Rekonstitution der Spaltungsreaktion durchgeführt.
description: Nearly all known messengerRNAs (mRNAs) are co-transcriptionally modified. One of these modifications is the cleavage and subsequent polyadenylation of the nascent mRNA at its 3’-end. The thus build poly(A) tail has significant influence upon the stability of the mRNA, as well as upon the efficiency of its export and translation. Thereby the poly(A) tail plays a decisive role in the fate of every produced mRNA. Despite of being investigated for over thirty years now, the reactions of cleavage and polyadenylation could yet not be reconstituted in an in vitro system with proteins from recombinant sources only. This work presents the reconstitution of the polyadenylation reaction from recombinantly produced proteins, defining the minimal set of essential protein factors for the catalysis of this reaction. Furthermore this work contains promising preliminary studies toward the in vitro reconstitution of the cleavage reaction.
Improving NPO'S accountability in the enlarged EU: towards a common framework for financial reporting in European NPOS
Creators: name: Travaglini, Claudio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: SECS-P/07 Economia aziendale

description: Not for Profit Organizations (NPOs) are the subject in the middle of a relevant debate by scholars, politicians and public opinion. The European Commission issued ten years ago a Communication regarding the promotion of associations’ and foundations’ role, the problems and the challenges they have to face to improve their actions and to be able to better operate in a European context.
Some efforts were done to measure economic dimensions of “third sector” by Research centres and international institutions while there is a remarkable lack of homogeneity concerning NPOs’ accounting regulation in the European Union. Each country has its own accounting regulatory system, strongly depending by civil and tax laws; this reduces both NPO’s disclosure and prevents scholars to comprehend the real state of social economy system at European level and their financial performance. Moreover it makes NPOs’ chance to operate in a foreign country  into the enlarged EU very difficult and make difficult an homogeneity in NPOs treatment at European level.
A European agenda to support the accountability development in the third sector should define a minimum common framework for institutional and governance features, financial accounting and social accountability for different kinds of NPO, beginning starting from the different national regulations. In particular an hypothesys of “European NPOss’ framework” for financial reporting (a first step to  a better accountability) hasve to consider different regulations  in order to:
a) legal entities form in which NPOs arehave constituted instituted in EU countries end and their regulations (specific for NPOs or general for commercial entities);
b) accounting and auditing obligations (keep accounting records, prepare annual accounts, provide financial reporting) and audit them;
c) mandatory annual report provided by the NPOs (mission statement, asset and liability statement, statement of financial activities, explanatory notes, trustees report) 
d) disclosure of accounts disclosure (make the accounts available to the public on request or deposit it in a public register); 
e) accounting principles for NPOs (cash or accrual basis, light regulation for smaller entities, Ifrs implementation);
f) a model for NPOs financial performance evaluation based on financial statement (significant ratio in accounting aggregates; 
To define a common framework we start from a comparationmatching between Spanish, Italian, and English regulations (law and practice) applied to NPOs to highlight similarities and differences. The paper is the first step of a wider research whose final goal is a “meeting path” to a common accounting framework for non profit organizations in European Union.
Design, synthesis and biological evaluation of two classes of antimycobacterial cyclic hexa(depsi)peptides
Creators: name: Sahile, Henok Asfaw
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 572

description: Zielsetzung der Dissertation war die Evaluierung des antituberkulösen Potentials zweier cyclischer Hexa(depsi)peptide natürlichen Ursprungs mittels Design, Synthese, Bestimmung der Wirksamkeit und der pharmakokinetischen Eigenschaften. Die Substanzbibliotheken der beiden Leitstrukturen Wollamid B und Hirsutellid A wurden mit der Standard-Festphasen-Peptid-Synthese (SPPS) hergestellt. Die antimykobakterielle Aktivität der Leitsubstanzen und aller synthetisierter Analoga wurde gegen M. tuberculosis H37Rv getestet. Zusätzlich wurden der in vitro Metabolismus und das pharmakokinetische Profil (ADME) ausgekundschaftet. Wollamid B und sechs Analoga erwiesen sich als potente antimykobakterielle Substanzen (MHK=0.60-3.1 µM), die keinerlei Cytotoxizität zeigten. Die extrazellulären MHKs konnten durch hervorragende intrazelluläre Wirksamkeit gegenüber Mtb H37Rv infizierter menschlicher Makrophagen bestätigt werden (IC50=0.16-2.10 µM). Die in vitro ADME-Profile belegten zwar bemerkenswerte Plasmastabilität und Wasserlöslichkeit, aber auch eine mittelmäßig bis niedrige metabolische Stabilität der Wollamide. Hirsutellid A und seine synthetisierten Analoga zeigten nur eine schwache antimykobakterielle Aktivität.
description: The thesis aimed at exploring the anti TB potential of two natural cyclic hexa(depsi)peptides by designing, synthesizing and evaluating their activities and pharmacokinetics. The two lead compounds were wollamide B and hirsutellide A. To achieve the goal, libraries of analogues to both compounds were synthesized by standard solid phase peptide synthesis approach (SPPS). The antimycobacterial activities of the leads and all the synthesized analogues were tested against M.tuberculosis H37Rv. Parallely, in vitro drug metabolism and pharmacokinetic (ADME) properties were evaluated. The result revealed the potent in vitro antimycobacterial activity of wollamide B and six analogues (MIC=0.60-3.1 µM) which was devoid of cytotoxicity. The extracellular MICs were further substantiated with their excellent intracellular potency (IC50=0.16-2.10 µM) against Mtb H37Rv infected human macrophages. The in vitro ADME profiling proved the remarkable plasma stability and aqueous solubility of the class while the metabolic stability was moderate to low. On the other hand, hirsutellide A and the synthesized analogues showed weak antimycobacterial potencies.
Nonexistence of extremals for the adjoint restriction inequality on the hyperboloid
Creators: name: Quilodrán, René
Publisher: name: arXiv
Year: 2011
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We study the problem of existence of extremizers for the $L^2$ to $L^p$ adjoint Fourier restriction inequalities on the hyperboloid in dimensions 3 and 4, in which cases $p$ is an even integer. We will use the method developed by Foschi to show that extremizers do not exist.
description: 32 pages. Correction for Theorem 1.2 and Proposition 7.5 and addition of Remark 1.3
La tutela delle risorse biologiche marine. Profili generali e sua applicazione allo spazio costiero adriatico.
Creators: name: Garzia, Giuseppe
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: IUS/10 Diritto amministrativo

description: G.GARZIA, LA TUTELA DELLE RISORSE BIOLOGICHE MARINE. PROFILI GENERALI E SUA APPLICAZIONE ALLO SPAZIO COSTIERO ADRIATICO.


Lo scopo dello studio è quello di analizzare il quadro normativo vigente relativo alla tutela delle risorse biologiche marine, con specifico riferimento al mare Adriatico.
Come osserva l’Autore si tratta di una ricostruzione non agevole a causa delle numerose normative (soprattutto recenti) che hanno disciplinato a vari livelli il tema. Tra l’altro esse riguardano settori diversi di azione della politica comunitaria e statali quali la tutela dell’ambiente (nelle sue diverse articolazioni), la pesca, etc.
Con il presente articolo l’Autore si propone di ricostruire il quadro generale anche con riferimento ai progetti di istituzione di organismi di carattere transnazionali in area adriatica (regione EUROADRIATICA).
Infine vengono individuate alcuni principi (o linee guida) sui quali dovrebbe fondarsi una corretta ed efficace disciplina di riforma della materia al fine di perseguire il principio dello sviluppo sostenibile.

The aim of the research is to analyze the legal framework regarding the biological marine resources, in particular the Adriatic coasts.
As the Author observes this is not an easy reconstruction because of the several laws (in particular the last ones) stating different levels of the topic. They are concerning other topics of E.U. politics as well as national ones such as the protection of the environment, fishing, etc. 
This article aims to reconstruct the general legal framework referring to trans-national organizations like EUROADRIATIC Region.
Finally, a few principles or guidelines will be underlined on which a correct and efficient regulation of the topic should be founded in order to achieve the sustainable development principle.
Proceedings of the 6th International Symposium on the Mediterranean Pig. October 11 – 13, 2007. Messina - Capo d’Orlando (ME), Italy
Creators: name: Nanni Costa, Leonardo
name: Zambonelli, Paolo
name: Russo, Vincenzo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: AGR/18 Nutrizione e alimentazione animale
AGR/19 Zootecnica speciale
VET/06 Parassitologia e malattie parassitarie degli animali
AGR/17 Zootecnica generale e miglioramento genetico

description: These proceedings publish 79 communications that were distributed in six sessions and in one conference at the 6th Symposium on the Mediterranean Pig, both as main lectures, oral and poster presentation. The major arguments treated are the improvement and the management of the genetic resources, the sanitary approaches in the outdoor systems, the feeding and the rearing techniques, the quality of meat and meat products, the traceability for typical products and their socio-economical dynamics. Particular attention is given to the pig's local breeds and to their meat products, highlighting the importance to preserve the biodiversity as well as the typicality of some unique pork products. The monitoring of pig parasitic diseases is examined as well as the non conventional rearing systems used for typical pig breeds and their effects on the pork quality. It is highlighted also the importance of the products traceability and the need to better understand the purchasing dynamics of typical pork products.
Materialkompositionen für Lithiumionenbatterien
Creators: name: Mathies, Lena Katharina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 530

description: Diese Arbeit untersucht die strukturellen und elektrischen Eigenschaften von Materialkompositionen für Lithiumionenbatterien. Funktionale Schichten auf Basis des nicht-koordinierenden Copolymer P(VdF-HFP) wurden aus der Lösung mittels Rakelverfahren hergestellt. Für den Einsatz als Elektrolytschicht konnte durch die Zugabe von Lithiumsalz (LiTfSI) und die Einbettung lithiumleitfähiger Keramikpartikel (Li7La3Zr2O12) die Gesamtleitfähigkeit der Schichten auf 10-4 S/cm gesteigert werden. Der Transportmechanismus der Lithiumionen wurde untersucht. Für den Einsatz als Kathodenschichten wurden aktive LiFePO4-Partikel in die modifizierte Matrix eingebettet. Die Kombination von polymerbasierten Elektrolyt- und Kathodenschichten wurde mit Lithiummetall in einer Knopfzelle zusammengebaut. Der Machbarkeitsnachweis für die Eignung der Materialsysteme für Lithiumionenbatterien konnte erbracht werden. Die Batteriezelle lässt sich reversibel laden und entladen und zeigt eine Effizienz von 99%.
description: This work investigates the structural and electrical properties of polymer-based material compositions for lithium ion batteries. Thin films based on the non-coordinating copolymer P(VdF-HFP) were fabricated via doctor blade casting. For the implementation as electrolyte layer the addition of lithium salt (LiTfSI) and lithium conducting particles (Li7La3Zr2O12) yielded conductivities of up to 10-4 S/cm. The transport mechanism was investigated. For the application as cathode layers active LiFePO4-particles were embedded in the modified matrix. The combination of polymer-based electrolyte and cathode layer was assembled into a coin cell with lithium metal as anode. The prove of principle for the suitability of the combined material systems for lithium ion batteries was achieved. The battery cell showed reversible charging and discharging with an efficiency of 99%.
Individual and spousal neuroticism are differentially associated with daily affect quality and physical symptoms in old age
Creators: name: Lay, Jennifer Christina
Publisher: name: University of British Columbia
Year: 2014

description: Objective: Marriage partners exert a special influence on each other’s health and wellbeing, potentially even more so in old age, when social networks shrink and spouses become ever more important resources for dealing with everyday problems. This study complements and extends past research by examining associations between older spouses’ levels of neuroticism, a key trait tied to wellbeing and health, and everyday fluctuations in affect quality, physical symptoms, and responses to everyday problems. Methods: Forty-nine wives and 49 husbands aged 60-83 years (M marriage duration = 42.5 years) first provided independent neuroticism self-report ratings. Spouses then completed up to 27 repeated daily life assessments (time-sampling), during which they simultaneously reported their affect quality, physical health symptoms, and everyday problems 3 times daily for 9 consecutive days on handheld computers. Results: Hierarchical linear modelling results replicate past work by showing negative associations between individual neuroticism and overall affect quality and physical symptoms. Interestingly, spousal neuroticism, in contrast, was positively associated with affect quality and physical symptoms, but only when problems were present. Specifically, having a spouse higher in neuroticism was associated with more favorable problem-affect quality associations and problem-physical symptom associations, even when controlling for marital satisfaction, age, gender, and level of conscientiousness. Conclusions: Findings are discussed in the context of the evolutionary psychology literature and may suggest that spousal neuroticism can serve adaptive functions by increasing vigilance and preparing older couples to deal with everyday problems.
Studio per la conoscenza e la conservazione del manoscritto Phillipps 9589
Creators: name: Lorusso, Salvatore
name: Natali, Andrea
name: Matteucci, Chiara
name: Savigni, Raffaele
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: CHIM/12 Chimica dell'ambiente e dei beni culturali

description: Il presente lavoro riguarda lo studio del Codice dantesco miniato su pergamena conservato presso la Biblioteca del Centro Dantesco dei Frati Minori Conventuali di Ravenna. Tale codice è noto alla comunità scientifica internazionale con la sigla di Phillipps 9589 e deve la sua notorietà al fatto non solo di essere l’unico palinsesto dantesco, ma anche di conservare, nella scriptio superior, uno tra i testimoni più antichi di quel ramo della tradizione manoscritta della Commedia di Dante chiamata “tradizione α”, la cosiddetta “antica vulgata”.
La ricerca, svolta in più fasi, si è proposta di approfondire gli aspetti tecnico-diagnostici, in particolare le finalità generali sono state:valutazione dello stato di conservazione; caratterizzazione dei materiali; miglioramento della leggibilità del testo dantesco e lettura del palinsesto; valutazione dell’ambiente di conservazione; digitalizzazione del codice per una fruizione intranet ed internet. A tal riguardo ci si è avvalsi dell’impiego delle seguenti tecniche diagnostiche non-distruttive anche a scopo documentario: fotografia digitale; videomicroscopio ad analisi di immagine; colorimetria spettrofotometrica; fluorescenza a raggi X (XRF); sistema multispettrale per l’acquisizione di immagini (MuSIS Multispectral Imaging System); strumentazioni per il monitoraggio ambientale (termoigrometro, luxmetro, prelevatore polveri PTS e PM10).
Inhomogeneous Vortex Patterns in Rotating Bose-Einstein Condensates
Creators: name: Correggi, Michele
name: Rougerie, Nicolas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider a 2D rotating Bose gas described by the Gross-Pitaevskii (GP) theory and investigate the properties of the ground state of the theory for rotational speeds close to the critical speed for vortex nucleation. While one could expect that the vortex distribution should be homogeneous within the condensate we prove by means of an asymptotic analysis in the strongly interacting (Thomas-Fermi) regime that it is not. More precisely we rigorously derive a formula due to Sheehy and Radzihovsky [Phys. Rev. A 70, 063620(R) (2004)] for the vortex distribution, a consequence of which is that the vortex distribution is strongly inhomogeneous close to the critical speed and gradually homogenizes when the rotation speed is increased. From the mathematical point of view, a novelty of our approach is that we do not use any compactness argument in the proof, but instead provide explicit estimates on the difference between the vorticity measure of the GP ground state and the minimizer of a certain renormalized energy functional.
description: 41 pages, journal ref: Communications in Mathematical Physics: Volume 321, Issue 3 (2013), Page 817-860, DOI : 10.1007/s00220-013-1697-y
Molekulare Charakterisierung des Stammzellmarkers LGR5 und der Spleißvariante LGR5Δ5 in humanen Tumoren
Creators: name: Rot, Swetlana
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 572

description: LGR5 ist ein mit dem Wnt-Signalweg assoziierter, G-Protein-gekoppelter Rezeptor und ein molekularer Marker von Stammzellen verschiedener Organsysteme. In Tumoren wird LGR5 verstärkt exprimiert und korreliert mit negativen klinischen Parametern. In dieser Arbeit wurde die tumorbiologische Relevanz des LGR5 und der Spleißvariante LGR5Δ5 untersucht. Eine veränderte LGR5FL- bzw. LGR5Δ5-Expression in vitro hatte zelllinienabhängig unterschiedliche Effekte auf das klonogene Langzeitüberleben, die Migrationsrate und die Sphäroidbildungsfähigkeit sowie auf die Expression von EMT- und Wnt-Zielgenen. Dabei beeinflusste die Spleißvariante LGR5Δ5, welcher die Liganden-Interaktionsstelle fehlt, das zellbiologische Verhalten und die Genexpressionsmuster gleichermaßen wie LGR5FL. In in vivo Analysen stellte die LGR5Δ5-mRNA, nicht jedoch LGR5FL-mRNA, einen unabhängigen prognostischen Marker für Patienten mit einem oralen Plattenepithelkarzinom oder einem Weichteilsarkom dar. Die Ergebnisse der vorliegenden Arbeit bestätigen die Einbindung des LGR5 sowohl in vitro als auch in vivo in Prozesse der Proliferation, Metastasierung und EMT.
description: LGR5 is a Wnt pathway associated G-protein-coupled receptor and a potential stem cell marker for multiple tissues. LGR5 has been found to be overexpressed in various types of human cancers and is significantly associated with poor clinical outcome. This study investigated the impact of LGR5 as well as of its splice variant LGR5Δ5 on tumor-associated parameters. Through knock-down or overexpression of LGR5FL or LGR5Δ5 in different cancer cells, the expression levels of LGR5FL/LGR5Δ5 was found to be related to clonogenicity, migration and spheroid formation as well as to expression levels of EMT markers and Wnt target genes in a cell line specific manner. Remarkably, the overexpression of the LGR5Δ5, the variant lacking the postulated ligand interaction interface, was found to induce analogous effects to overexpression of full length LGR5. Furthermore, the mRNA level of LGR5Δ5, but not of LGR5FL, was identified as an independent prognostic marker correlated with a poor outcome of STS or OSCC patients. Taken together, these results demonstrate that LGR5 is involved in vitro and in vivo in processes affecting proliferation, dissemination und EMT.
The modern tools of quantum mechanics (A tutorial on quantum states, measurements, and operations)
Creators: name: Paris, Matteo G. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This tutorial is devoted to review the modern tools of quantum mechanics, which are suitable to describe states, measurements, and operations of realistic, not isolated, systems in interaction with their environment, and with any kind of measuring and processing devices. We underline the central role of the Born rule and and illustrate how the notion of density operator naturally emerges, together the concept of purification of a mixed state. In reexamining the postulates of standard quantum measurement theory, we investigate how they may formally generalized, going beyond the description in terms of selfadjoint operators and projective measurements, and how this leads to the introduction of generalized measurements, probability operator-valued measures (POVM) and detection operators. We then state and prove the Naimark theorem, which elucidates the connections between generalized and standard measurements and illustrates how a generalized measurement may be physically implemented. The "impossibility" of a joint measurement of two non commuting observables is revisited and its canonical implementations as a generalized measurement is described in some details. Finally, we address the basic properties, usually captured by the request of unitarity, that a map transforming quantum states into quantum states should satisfy to be physically admissible, and introduce the notion of complete positivity (CP). We then state and prove the Stinespring/Kraus-Choi-Sudarshan dilation theorem and elucidate the connections between the CP-maps description of quantum operations, together with their operator-sum representation, and the customary unitary description of quantum evolution. We also address transposition as an example of positive map which is not completely positive, and provide some examples of generalized measurements and quantum operations.
description: Tutorial. 26 pages, 1 figure. Published in a special issue of EPJ - ST devoted to the memory of Federico Casagrande
A Multi-Theory Logic Programming Language for the World Wide Web
Creators: name: Piancastelli, Giulio
name: Omicini, Andrea
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: ING-INF/05 Sistemi di elaborazione delle informazioni

description: Despite the World Wide Web recent architectural formalization in terms of Representational State Transfer (REST) architectural style and Resource-Oriented Architecture (ROA), current languages and tools for Web programming generally suffer from a lack of understanding of its design constraints and from an abstraction mismatch that makes it difficult to fully exploit the Web potential.
Based on the insights gained by REST and ROA, we claim that logic languages are well-suited for promoting the Web architecture and principles: in particular, the straightforward mapping of REST and ROA abstractions onto elements of Contextual Logic Programming allows for directly executable logic-based resource representations, as well as dynamic modification of resource behaviour at runtime.
Along this line, in this paper we present Web Logic Programming as a Prolog-based language for the World Wide Web embedding the core REST and ROA principles, intended to work as the basis of a framework for the rapid prototyping of Web applications.
We define the language operational semantics and discuss some simple but significant programming examples.
title: Errancias por el laberinto de los signos. En torno a La ciudad letrada y sus debates
Creators: name: Herrera Pardo, Hugo
Publisher: name: Iberoamericana/Vervuert
Year: 2021
Subjects: subject: 860

description: Bibliotheca Ibero-Americana, vol. 185Políticas y estrategias de la crítica, II: ideología, historia y actores de los estudios literarios, p. 163