cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the role of N-terminal domain in phosphodiesterase 4B-inhibition by molecular dynamics simulation
Creators: name: Sharma, Vidushi
name: Wakode, Sharad
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Phosphodiesterase 4B (PDE4B) is a potential therapeutic target for the inflammatory respiratory diseases such as congestive obstructive pulmonary disease (COPD) and asthma. The sequence identity of ∼88% with its isoform PDE4D is the key barrier in developing selective PDE4B inhibitors which may help to overcome associated side effects. Despite high sequence identity, both isoforms differ in few residues present in N-terminal (UCR2) and C-terminal (CR3) involved in catalytic site formation. Previously, we designed and tested specific PDE4B inhibitors considering N-terminal residues as a part of the catalytic cavity. In continuation, current work thoroughly presents an MD simulation-based analysis of N-terminal residues and their role in ligand binding. The various parameters viz. root mean square deviation (RMSD), radius of gyration (Rg), root mean square fluctuation (RMSF), principal component analysis (PCA), dynamical cross-correlation matrix (DCCM) analysis, secondary structure analysis and residue interaction mapping were investigated to establish rational. Results showed that UCR2 reduced RMSF values for the metal binding pocket (31.5 ± 11 to 13.12 ± 6 Å2) and the substrate-binding pocket (38.8 ± 32 to 17.3 ± 11 Å2). UCR2 enhanced anti-correlated motion at the active site region that led to the improved ligand-binding affinity of PDE4B from −24.57 ± 3 to −35.54 ± 2 kcal/mol. Further, the atomic-level analysis indicated that T-π and π-π interactions between inhibitors and residues are vital forces that regulate inhibitor association to PDE4B with high affinity. In conclusion, UCR2, the N-terminal domain, embraces the dynamics of PDE4B active site and stabilizes PDE4B inhibitor interactions. Therefore the N-terminal domain needs to be considered while designing next-generation, selective PDE4B-inhibitors as potential anti-inflammatory drugs. Communicated by Ramaswamy H. Sarma
Jens Dolata, Römische Ziegelstempel aus Mainz. Teil I. Militärische Ziegelstempel des i. Jahrhunderts (Materialvorlage)
Creators: name: Hanel, Norbert
Publisher: name: Bonner Jahrbücher
Year: 2020

description: Rezension zu: Jens Dolata, Römische Ziegelstempel aus Mainz. Teil i: Militärische Ziegelstempel des i. Jahrhunderts (Materialvorlage). Mainzer Archäologische Schriften, Band 13. Selbstverlag der Direktion Landesarchäologie Mainz 2014. 420 Seiten, 97 Abbildungen, 125 Tafeln, 16 Karten, 1 CD-Rom.
description: Bonner Jahrbücher, Bd. 215.2015(2016): Bonner Jahrbücher
Low frequency oscillations in black holes: a spectral-timing approach to the case of GX 339-4
Creators: name: Motta, S.
name: Muñoz-Darias, T.
name: Casella, P.
name: Belloni, T.
name: Homan, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We analyzed RXTE/PCA and HEXTE data of the transient black hole binary GX 339-4, col- lected over a time span of eight years. We studied the properties and the behavior of low frequency quasi periodic oscillations (QPOs) as a function of the integrated broad-band variability and the spectral parameters during four outbursts (2002, 2004, 2007, 2010). Most of the QPOs could be classified following the ABC classification that has been proposed before. Our results show that the ABC classification can be extended to include spectral dependencies and that the three QPO types have indeed intrinsically different properties. In terms of the relation between QPO frequency and power-law flux, type-A and -C QPOs may follow the same relation, whereas the type-B QPOs trace out a very different relation. Type-B QPO frequencies clearly correlate with the powerlaw-flux and are connected to local increases of the count rate. The frequency of all QPOs observed in the rising phase of the 2002, 2007 and 2010 outburst correlate with the disk flux. Our results can be interpreted within the framework of recently proposed QPO models involving Lense-Thirring precession. We suggest that type- C and -A QPOs might be connected and could be interpreted as being the result of the same phenomenon observed at different stages of the outburst evolution, while a different physical process produces type-B QPOs.
description: 18 pages, 11 figures, 4 tables. Accepted for publication in MNRAS
Nilotanypus Kieffer 1923
Creators: name: Armitage, Brian J.
name: Andersen, Trond
name: Giłka, Wojciech
name: Castillo Sánchez, Kayla N.
name: Ríos González, Tomás A.
name: Aguirre, Yusseff P.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Nilotanypus

description: Genus Nilotanypus Kieffer, 1923
A genus of 12 named species distributed in all zoogeographical regions except Antarctica and Oceania. Three species are described from Brazil (Andersen & Pinho 2019; Shimabukuro et al. 2021). The larvae inhabit flowing waters, especially areas with sandy beds (Cranston & Epler 2013).
description: Published as part of Armitage, Brian J., Andersen, Trond, Giłka, Wojciech, Castillo Sánchez, Kayla N., Ríos González, Tomás A. & Aguirre, Yusseff P., 2025, The Diptera of Panama. II. A first benchmark for the family Chironomidae, pp. 201-240 in Zootaxa 5613 (2) on page 230, DOI: 10.11646/zootaxa.5613.2.1, http://zenodo.org/record/15224174
Eike Faber, Von Ulfila bis Rekkared. Die Goten und ihr Christentum
Creators: name: Heil, Uta
Publisher: name: Bonner Jahrbücher
Year: 2020

description: Rezension zu: Eike Faber, Von Ulfila bis Rekkared. Die Goten und ihr Christentum. Potsdamer Altertumswissenschaftliche Beiträge, Band 51. Franz Steiner Verlag, Stuttgart 2014. 300 Seiten mit 5 Abbildungen
description: Bonner Jahrbücher, Bd. 215.2015(2016): Bonner Jahrbücher
Virtual Screening-Driven Drug Discovery of SARS-CoV2 Enzyme Inhibitors Targeting Viral Attachment, Replication, Post-Translational Modification and Host Immunity Evasion Infection Mechanisms
Creators: name: Quimque, Mark Tristan J.
name: Notarte, Kin Israel R.
name: Fernandez, Rey Arturo T.
name: Mendoza, Mark Andrew O.
name: Liman, Rhenz Alfred D.
name: Lim, Justin Allen K.
name: Pilapil, Luis Agustin E.
name: Ong, Jehiel Karsten H.
name: Pastrana, Adriel M.
name: Khan, Abbas
name: Wei, Dong-Qing
name: Macabeo, Allan Patrick G.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The novel coronavirus SARS-CoV2, the causative agent of the pandemic disease COVID-19, emerged in December 2019 forcing lockdown of communities in many countries. The absence of specific drugs and vaccines, the rapid transmission of the virus, and the increasing number of deaths worldwide necessitated the discovery of new substances for anti-COVID-19 drug development. With the aid of bioinformatics and computational modelling, ninety seven antiviral secondary metabolites from fungi were docked onto five SARS-CoV2 enzymes involved in viral attachment, replication, post-translational modification, and host immunity evasion infection mechanisms followed by molecular dynamics simulation and in silico ADMET prediction (absorption, distribution, metabolism, excretion and toxicity) of the hit compounds. Thus, three fumiquinazoline alkaloids scedapin C (15), quinadoline B (19) and norquinadoline A (20), the polyketide isochaetochromin D1 (8), and the terpenoid 11a-dehydroxyisoterreulactone A (11) exhibited high binding affinities on the target proteins, papain-like protease (PLpro), chymotrypsin-like protease (3CLpro), RNA-directed RNA polymerase (RdRp), non-structural protein 15 (nsp15), and the spike binding domain to GRP78. Molecular dynamics simulation was performed to optimize the interaction and investigate the stability of the top-scoring ligands in complex with the five target proteins. All tested complexes were found to have dynamic stability. Of the five top-scoring metabolites, quinadoline B (19) was predicted to confer favorable ADMET values, high gastrointestinal absorptive probability and poor blood-brain barrier crossing capacities.
Appendices Of Boundary Negotiating Artifacts In Personal Informatics: Patient-Provider Collaboration With Patient-Generated Data
Creators: name: Chung, Chia-Fang
name: Dew, Kristin
name: Cole, Allison
name: Zia, Jasmine
name: Forgarty, James
name: Kientz, Julie A.
name: Munson, Sean A.
Publisher: name: Zenodo
Year: 2015

description: Patient survey and interview protocol of Boundary Negotiating Artifacts in Personal Informatics: Patient-Provider Collaboration with Patient-Generated Data
IIB Superfluid Flows
Creators: name: Arean, Daniel
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We construct holographic superfluid flow solutions in a five-dimensional theory that arises as a consistent truncation of low energy type IIB string theory. We then study the phase diagram of these systems in terms of the temperature and superfluid velocity. Finally, we construct solutions representing the ground state of these superfluids for velocities below a critical value. These are charged anisotropic AdS domain walls that demonstrate the emergence of quantum criticality in the IR.
description: Contribution to the XVII European Workshop on String Theory 2011 (Padova, September 2011)
title: RECENZJA KSIĄŻKI - Joanna i Rafał Pasztelańscy "Policjanci. Za cenę życia"
Creators: name: Sprengel, Bolesław
name: Amrozy, Katarzyna
Publisher: name: Studia nad Bezpieczeństwem, Nr 2 (2017): Studia nad Bezpieczeństwem, s. 173-176
Year: 2017

description: Nr 2 (2017): Studia nad Bezpieczeństwem, 173-176
Synthesis, characterization, theoretical, molecular docking and in vitro biological activity studies of Ru(II) (η6-p-cymene) complexes with novel aniline substituted aroyl selenoureas
Creators: name: Musthafa, Moideen
name: Konakanchi, Ramaiah
name: Ganguly, Rakesh
name: Balachandran, Chandrasekar
name: Aoki, Shin
name: Sreekanth, Anandaram
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: A sequence of aroyl selenourea ligands (L1–L3) substituted by aniline and their Ru(II) (η6-p-cymene) complexes (1-3), [Ru(II) (η6-p-cymene) L] (L = monodentate aroyl selenourea ligand) have been synthesized and characterized the composition of the ligands and their metal complexes. The molecular structures of ligand L1 and complex 3 were also confirmed by single XRD crystal method. The single-crystal XRD study showed that aroyl selenourea ligand coordinates with Ru via Se novel neutral monodentate atom. In vitro DNA interaction studies were investigated by Fluorescence and UV-Visible spectroscopic methods which showed that the intercalative mode of binding is in the order of 1 > 2 > 3 with Ru(II) (η6-p-cymene) complexes. Spectroscopic methods have been used for measuring the binding affinity of bovine serum albumin to complex. Moreover, the cytotoxic study of complexes (1–3) were evaluated against HeLa S3, A549, and IMR90 cells, resulting in complexes 1 and 2 showed promising cytotoxic activity against HeLa S3 cell with IC50 values of 24 and 26 µM, respectively. Also, the morphological changes of HeLa S3 and A549 cells were confirmed by fluorescence microscope in the presence of complexes 1 and 2 using AO (acridine orange, 200 µM) and EB (ethidium bromide, 100 µM). In addition, the docking results strongly support the protein binding studies of the complexes. Communicated by Ramaswamy H. Sarma
Andreas Hensen (Herausgeber), Das große Forum von Lopodunum
Creators: name: Krieger, Elisabeth
Publisher: name: Bonner Jahrbücher
Year: 2020

description: Rezension zu: Andreas Hensen (Herausgeber), Das große Forum von Lopodunum. Mit Beiträgen von Johannes Eingartner, Jürgen Süß, Eva-Maria Lackner, Christian Witschel und Brigitte Gräf. Lares. Ladenburger Reihe zur Stadtgeschichte, Band 1. Edition Ralf Fetzer, Edingen-Neckarhausen 2016. 172 Seiten mit 91 Abbildungen.
description: Bonner Jahrbücher, Bd. 216.2016(2017): Bonner Jahrbücher
Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach
Creators: name: Chikhale, Rupesh V.
name: Gurav, Shailendra S.
name: Patil, Rajesh B.
name: Sinha, Saurabh K.
name: Prasad, Satyendra K.
name: Shakya, Anshul
name: Shrivastava, Sushant K.
name: Gurav, Nilambari S.
name: Prasad, Rupali S.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: COVID-19 has ravaged the world and is the greatest of pandemics in modern human history, in the absence of treatment or vaccine, the mortality and morbidity rates are very high. The present investigation identifies potential leads from the plant Withania somnifera (Indian ginseng), a well-known antiviral, immunomodulatory, anti-inflammatory and a potent antioxidant plant, using molecular docking and dynamics studies. Two different protein targets of SARS-CoV-2 namely NSP15 endoribonuclease and receptor binding domain of prefusion spike protein from SARS-CoV-2 were targeted. Molecular docking studies suggested Withanoside X and Quercetin glucoside from W. somnifera have favorable interactions at the binding site of selected proteins, that is, 6W01 and 6M0J. The top-ranked phytochemicals from docking studies, subjected to 100 ns molecular dynamics (MD) suggested Withanoside X with the highest binding free energy (ΔGbind = −89.42 kcal/mol) as the most promising inhibitor. During MD studies, the molecule optimizes its conformation for better fitting with the receptor active site justifying the high binding affinity. Based on proven therapeutic, that is, immunomodulatory, antioxidant and anti-inflammatory roles and plausible potential against n-CoV-2 proteins, Indian ginseng could be one of the alternatives as an antiviral agent in the treatment of COVID 19. Communicated by Ramaswamy H. Sarma HighlightsWithania somnifera has antiviral potential.Phytochemicals of Ashwagandha showed promising in silico docking and molecular dynamics results.Withanoside X and Quercetin glucoside have a good binding with protein targets.Indian Ginseng holds promise as SARS-COV-2 (S) and (N) proteins inhibitor. Withania somnifera has antiviral potential. Phytochemicals of Ashwagandha showed promising in silico docking and molecular dynamics results. Withanoside X and Quercetin glucoside have a good binding with protein targets. Indian Ginseng holds promise as SARS-COV-2 (S) and (N) proteins inhibitor.
Jonathan Master, Provincial Soldiers and Imperial Instability in the Histories of Tacitus
Creators: name: Lambrecht, Ulrich
Publisher: name: Bonner Jahrbücher
Year: 2020

description: Rezension zu: Jonathan Master, Provincial Soldiers and Imperial Instability in the Histories of Tacitus. University of Michigan Press, Ann Arbor 2016. IX und 238 Seiten.
description: Bonner Jahrbücher, Bd. 216.2016(2017): Bonner Jahrbücher
Long Period Tidal Force Variations and Regularities in Orbital Motion of the Earth-Moon Binary Planet System
Creators: name: Avsyuk, Yu. N.
name: Maslov, L. A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: We have studied long period, 206 and 412 day, variations in tidal sea level corresponding to various moon phases collected from five observatories in the Northern and Southern hemispheres. Variations in sea level in the Bay of Fundy, on the eastern Canadian seaboard, with periods of variation 206 days, and 412 days, have been discovered and carefully studied by C. Desplanque and D. J. Mossman (2001, 2004). The current manuscript focuses on analyzing a larger volume of observational sea level tide data as well as on rigorous mathematical analysis of tidal force variations in the Sun-Earth-Moon system. We have developed a twofold model, both conceptual and mathematical, of astronomical cycles in the Sun-Earth-Moon system to explain the observed periodicity. Based on an analytical solution of the tidal force variation in the Sun-Earth-Moon system, it is shown that the tidal force can be decomposed into two components: the Keplerian component and the Perturbed component. The Perturbed component of the tidal force variation was calculated, and it was shown that the observed periodicity, 206 and 412 days, of atmospheric and hydrosphere tides results from variations of the Perturbed component of tidal force. The amplitude of the Perturbed component of tidal force is . It is the same order of magnitude as the amplitude of the Keplerian component of tidal force: . It follows that the Perturbed component of the variation of a tidal force must always be taken into consideration along with the Keplerian component in geodynamical constructions involving tides.
Inhibition of fibrillation of human γD-crystallin by a flavonoid morin
Creators: name: Rana, Shiwani
name: Ghosh, Kalyan Sundar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Hematology

description: To inhibit formation of amyloid fibrils by human γD-crystallin (HGD), a series of four flavonoids (quercertin, rutin, morin and hesperetin) was tested. Only morin had demonstrated significant inhibition of HGD fibrillation. Results from fluorimetric assay techniques (using thioflavin T and ANS), FTIR, circular dichroism and microscopic imaging (fluorescence microscopy and transmission electron microscopy) confirmed HGD fibrillation inhibition by morin. HGD-morin complex formation at ground state resulted Trp fluorescence quenching through static mechanism, which was also confirmed by determining the excited-state life time of HGD tryptophan residues. Förster resonance energy transfer occurs from HGD to morin. Synchronous, three-dimensional fluorescence, FTIR and CD results suggest that major changes in HGD conformation did not occur on binding with morin. The interactions between HGD and morin involve hydrogen bonding and/or van der Waals forces. Docking predictions also support experimental results.
Measurements of WW and WZ production in W + jets final states in p-pbar collisions
Creators: name: D0 Collaboration
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study WW and WZ production with $lνq{q}$ ($l=e,μ$) final states using data collected by the D0 detector at the Fermilab Tevatron Collider corresponding to 4.3 fb^-1 of integrated luminosity from p-pbar collisions at sqrt{s}=1.96 TeV. Assuming the ratio between the production cross sections $σ(WW)$ and $σ(WZ)$ as predicted by the standard model, we measure the total WV (V=W,Z) cross section to be $σ(WV)= 19.6^{+3.2}_{-3.0}$ pb, and reject the background-only hypothesis at a level of 7.9 standard deviations. We also use b-jet discrimination to separate the WZ component from the dominant WW component. Simultaneously fitting WW and WZ contributions, we measure $σ(WW) = 15.9^{+3.7}_{-3.2}$ pb and $σ(WZ) = 3.3^{+4.1}_{-3.3}$ pb, which is consistent with the standard model predictions.
description: 13 pages, 8 Figures, 3 Tables; To be submitted to Phys. Rev. Lett
Search for Lepton-number-violating B+->D-l+l'+ Decays
Creators: name: Seon, O.
name: Kwon, Y. J.
name: Iijima, T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We perform the first search for lepton-number-violating B+->D-l+l'+ decays, where l and l' stand for e or mu, using 772 x 10^6 BB-bar pairs accumulated at the Upsilon(4S) resonance with the Belle detector at the KEKB e^+e^- collider. No evidence for these decays has been found. Assuming uniform three-body phase space distributions for the D-l+l+ decays, we set the following upper limits on the branching fractions at 90% confidence level: Br(B+ -> D-e+e+) < 2.6x10^-6, Br(B+ -> D-e+mu+) < 1.8x10^-6 and Br(B+ -> D-mu+mu+) < 1.0x10^-6.
description: 7 pages, 2 figures
IVOA Recommendation: Vocabularies in the Virtual Observatory Version 1.19
Creators: name: Derriere, Sebastien
name: Gray, Alasdair J G
name: Gray, Norman
name: Hessman, Frederic V
name: Linde, Tony
name: Martinez, Andrea Preite
name: Seaman, Rob
name: Thomas, Brian
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: This document specifies a standard format for vocabularies based on the W3C's Resource Description Framework (RDF) and Simple Knowledge Organization System (SKOS). By adopting a standard and simple format, the IVOA will permit different groups to create and maintain their own specialised vocabularies while letting the rest of the astronomical community access, use, and combine them. The use of current, open standards ensures that VO applications will be able to tap into resources of the growing semantic web. The document provides several examples of useful astronomical vocabularies.
On certain Kähler quotients of quaternionic Kähler manifolds
Creators: name: Cortés, V.
name: Louis, J.
name: Smyth, P.
name: Triendl, H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Differential Geometry (math.DG)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We prove that, given a certain isometric action of a two-dimensional Abelian group A on a quaternionic Kähler manifold M which preserves a submanifold N\subset M, the quotient M'=N/A has a natural Kähler structure. We verify that the assumptions on the group action and on the submanifold N\subset M are satisfied for a large class of examples obtained from the supergravity c-map. In particular, we find that all quaternionic Kähler manifolds M in the image of the c-map admit an integrable complex structure compatible with the quaternionic structure, such that N\subset M is a complex submanifold. Finally, we discuss how the existence of the Kähler structure on M' is required by the consistency of spontaneous {\cal N}=2 to {\cal N}=1 supersymmetry breaking.
description: 36 pages
On the proficient use of GEV distribution: a case study of subtropical monsoon region in India
Creators: name: Shukla, Ripunjai K.
name: Trivedi, M.
name: Kumar, Manoj
Publisher: name: arXiv
Year: 2012
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: The paper deals with the probabilistic estimates of extreme maximum rainfall (Annual basis) in the Ranchi, Jharkhand (India). Extreme Value Distribution family models are tried to capture the uncertainty of data and finally Generalized Extreme Value (GEV) distribution model is found as the best fitted distribution model. The GEV model satisfied the selection criteria [Anderson-Darling test (A-D test or Goodness of fit test) and Normality test (Q-Q plot)], which are adopted under the present study. The return levels are estimated for 5, 10, 50, 100 and 200 years which are consistently increasing for long run in future.
description: 12 pages
title: ‘It’s not easy’: health and transnational belonging among West African immigrants in Philadelphia
Creators: name: Muhr, Ava
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: Transnational Belonging
subject: Healthcare Network
subject: Diasporic Communities
subject: Embodied Experiences
subject: Medical Anthropology

description: This thesis explores embodied experiences of migration among West African (im)migrants in Philadelphia, Pennsylvania, USA. Southwest Philadelphia is home to numerous long-standing and continually growing diasporas from across West Africa, primarily Liberia, Sierra Leone, Guinea-Conakry, Nigeria, Burkina Faso, Mali, Mauritania, the Gambia, and Côte d’Ivoire. Among the oldest and most substantial diasporas are those from Liberia and Sierra Leone, following the initial arrival of refugees in the early 1990s due to their respective civil wars (Liberia from 1989-2003; Sierra Leone from 1991-2001). Drawing on one year of fieldwork, this thesis explores how immigrants navigate, utilise, and experience differing forms of care in different clinical spaces, within families, and among diasporic communities, and in turn how these experiences reconfigure notions of belonging for individuals and families between Philadelphia and West Africa. Moreover, I argue that ethnographic attention to affective and bodily experiences of health, and the ways in which they become entangled with borders, is integral to understanding the production of post-migration ideas of a “better life”. This thesis outlines empirically what I term the fragmented and fragile healthcare network, enacted by a range of medical staff and aligned social service providers located at various clinical spaces and organisations throughout the city to assist West African immigrants to access various types of care. I argue that care within this network is a locus for expressing and articulating (dis)connection and belonging between West Africa and America in often contradictory and contested ways. In conjunction with biomedical interventions, this thesis explores the production of kinship relations across borders. Although families and communities are physically separated, bodies continue to mediate relationships on both sides of the Atlantic as acts of care for the living and the dead become crucial terrains for both reaffirming and producing new subjectivities. Thus, migrating to Philadelphia for the “American dream” becomes a project that is inherently fragmented and fragile, strung together through documents, medicine, friendships, pain, and community. This thesis contributes to Medical Anthropology, Migration Studies, and African Studies by highlighting the lived experiences of specific communities within Philadelphia that have been elided in ethnographic research, and showing how life is made and lived within America’s stratified moral economy of care.
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
Creators: name: Gupta, Sanjay
name: Singh, Atul Kumar
name: Kushwaha, Prem Prakash
name: Prajapati, Kumari Sunita
name: Shuaib, Mohd
name: Senapati, Sabyasachi
name: Kumar, Shashank
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may represent effective drug target. X-ray crystallographic structure of the SARS-CoV2 Mpro protein demonstrated the significance of Glu166, Cys141, and His41 residues involved in protein dimerization and its catalytic function. We performed in silico screening of compounds from Curcuma longa L. (Zingiberaceae family) against Mpro protein inhibition. Employing a combination of molecular docking, scoring functions, and molecular dynamics simulations, 267 compounds were screened by docking on Mpro crystallographic structure. Docking score and interaction profile analysis exhibited strong binding on the Mpro catalytic domain with compounds C1 (1E,6E)-1,2,6,7-tetrahydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione) and C2 (4Z,6E)‐1,5‐dihydroxy‐1,7‐bis(4‐hydroxyphenyl)hepta‐4,6‐dien‐3‐one as lead agents. Compound C1 and C2 showed minimum binding score (-9.08 and -8.07 kcal/mole) against Mpro protein in comparison to shikonin and lopinavir (≈ -5.4 kcal/mole) a standard Mpro inhibitor. Furthermore, principal component analysis, free energy landscape and protein-ligand energy calculation studies revealed that these two compounds strongly bind to the catalytic core of the Mpro protein with higher efficacy than lopinavir, a standard antiretroviral of the protease inhibitor class. Taken together, this structure based optimization has provided lead on two natural Mpro inhibitors for further testing and development as therapeutics against human coronavirus.
Triggering on electrons and photons with CMS
Creators: name: Zabi, Alexandre
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Throughout the year 2011, the Large Hadron Collider (LHC) has operated with an instantaneous luminosity that has risen continually to around 4x10^33cm-2 s-1. With this prodigious high-energy proton collisions rate, efficient triggering on electrons and photons has become a major challenge for the LHC experiments. The Compact Muon Solenoid (CMS) experiment implements a sophisticated two-level online selection system that achieves a rejection factor of nearly 106. The first level (L1) is based on coarse information coming from the calorimeters and the muon detectors while the High-Level Trigger (HLT) combines fine-grain information from all sub-detectors. In this intense hadronic environment, the L1 electron/photon trigger provides a powerful tool to select interesting events. It is based upon information from the Electromagnetic Calorimeter (ECAL), a high-resolution detector comprising 75848 lead tungstate (PbWO4) crystals in a "barrel" and two "endcaps". The performance as well as the optimization of the electron/photon trigger are presented
description: "Presented at the 2011 Hadron Collider Physics symposium (HCP-2011), Paris, France, November 14-18 2011, 4 pages, 3 figure. "
Cell apoptosis induced by ciprofloxacin based Cu(II) complexes: Cytotoxicity, SOD mimic and antibacterial studies
Creators: name: Bhatt, Bhupesh S.
name: Gandhi, Divyang H.
name: Vaidya, Foram U.
name: Pathak, Chandramani
name: Patel, Tushar N.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: The current cancer research focuses on the design and synthesis of chemical compounds that can modulate cell apoptosis or programmed cell death. So we synthesized and characterized ciprofloxacin based copper(II) complexes and studied their anticancer activity against HCT 116 cancer cells by MTT assay. We further investigated the influence of compound-2 (better IC50 value than cisplatin) on cancer cells to know the exact mechanism of anticancer activity. The distinct morphological change of cells due to compound-2 was observed in bright field microscopy. The trypan blue assay clearly demonstrated inhibition of cell viability. The clonogenic ability inhibition assay showed a low percentage of the plating efficiency of HCT 116 cells. The mechanism of cell death, either apoptotic or necrotic was distinguished by annexin V-FITC / PI (propidium iodide) staining assay and LDH (lactate dehydrogenase) release assay. The positive annexinV/PI cells in presence of compound-2 and absence of LDH in the LDH release assay confirmed the cell apoptotic mechanism of cell death. We also checked in vitro antibacterial activity of compounds against Gram(-ve) and Gram(+ve) bacteria in terms of MIC (minimum inhibitory concentration) and the data were in good agreement with the standard drug data. SOD mimic activity of synthesized Cu(II) complexes was also studied in terms of IC50 value. The brine shrimp lethality bioassay was also performed to evaluate the cytotoxic properties of the Cu(II) complexes.
Spin Diffusion Coefficient of A Phase of Liquid 3He at Low Temperatures and Stability of Half Quantum Vortex
Creators: name: Haghdani, Shokouh
name: Shahzamanian, Mohammad Ali
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We theoretically investigate the spin diffusion coefficient tensor in the A phase of liquid 3He in term of quasiparticle life-time by using the Kubo formula approach at low temperatures. In general, the coefficient is a fourth rank tensor for the anisotropic states and can be defined as a function of both normal component of spin-current and magnetization. The quasiparticle life-time is obtained by using the Boltzmann equation. We find that components of the spin diffusion coefficient are proportional to T^(-2) at low temperatures. The normal components of spin current, hence, are strongly diffusive and one can ignore the contribution of these components to the stability of half quantum vortices (HQV s) in the equal-spin-pairing of 3He-A state. Hence to make a stable HQV, it is enough for one to consider weak interaction plus the effects of Landau Fermi liquid.
Synthesis and Structural Analysis of New (−)-Cytisine  Squaramides
Creators: name: Huczyński, Adam
name: Przybył, Anna
name: Janczak, Jan
Publisher: name: Zenodo
Year: 2025
Subjects: squaric acid
cytisine

description: Derivatives of squaric acid are valuable building blocks with promising applications in the investigation of various bioactivities. In this study, we focus on squaramides functionalized with the (−)-cytisine moiety, an alkaloid known for its bioactivity as a nicotinic acetylcholine receptor agonist and its application in nicotine addiction treatment. Reactions of cytisine-monosquarate with several amines, such as ammonia, propargylamine, and morpholine, led to the formation of novel conjugates of cytisine-squaramides. Additionally, squaramide containing two cytisine moieties was synthesized via the reaction of diethyl squarate with cytisine at a 1:2 molar ratio. All obtained squaramides were thoroughly characterized by MS, FT-IR, and NMR methods and by single-crystal X-ray diffraction analysis. To gain deeper insights into their structural properties and intermolecular interactions, geometry optimizations were performed using DFT calculations, complemented with 3D molecular electrostatic potential maps.
The SAURON Project - XIX. Optical and near-infrared scaling relations of nearby elliptical, lenticular and Sa galaxies
Creators: name: Falcón-Barroso, J.
name: van de Ven, G.
name: Peletier, R. F.
name: Bureau, M.
name: Jeong, H.
name: Bacon, R.
name: Cappellari, M.
name: Davies, R. L.
name: de Zeeuw, P. T.
name: Emsellem, E.
name: Krajnović, D.
name: Kuntschner, H.
name: McDermid, R. M.
name: Sarzi, M.
name: Shapiro, K. L.
name: Bosch, R. C. E. van den
name: van der Wolk, G.
name: Weijmans, A.
name: Yi, S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: [Abridged] We present ground-based MDM V-band and Spitzer/IRAC 3.6um-band photometric observations of the 72 representative galaxies of the SAURON Survey. In combination with the SAURON stellar velocity dispersion measured within an effective radius (se), this allows us to explore the location of our galaxies in the main scaling relations. We investigate the dependence of these relations on our recent kinematical classification of early-type galaxies (i.e. Slow/Fast Rotators) and the stellar populations. Slow Rotator and Fast Rotator E/S0 galaxies do not populate distinct locations in the scaling relations, although Slow Rotators display a smaller intrinsic scatter. Surprisingly, extremely young objects do not display the bluest (V-[3.6]) colours in our sample, as is usually the case in optical colours. This can be understood in the context of the large contribution of TP-AGB stars to the infrared, even for young populations, resulting in a very tight (V-[3.6]) - se relation that in turn allows us to define a strong correlation between metallicity and velocity dispersion. Many Sa galaxies appear to follow the Fundamental Plane defined by E/S0 galaxies. Galaxies that appear offset from the relations correspond mostly to objects with extremely young populations, with signs of on-going, extended star formation. We correct for this effect in the Fundamental Plane, by replacing luminosity with stellar mass using an estimate of the stellar mass-to-light ratio, so that all galaxies are part of a tight, single relation. The new estimated coefficients are consistent in both photometric bands and suggest that differences in stellar populations account for about half of the observed tilt with respect to the virial prediction. After these corrections, the Slow Rotator family shows almost no intrinsic scatter around the best-fit Fundamental Plane.
description: Accepted for publication in MNRAS. 32 pages, 20 figures, LaTeX
Spectral Duality in Integrable Systems from AGT Conjecture
Creators: name: Mironov, A.
name: Morozov, A.
name: Zenkevich, Y.
name: Zotov, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We describe relationships between integrable systems with N degrees of freedom arising from the AGT conjecture. Namely, we prove the equivalence (spectral duality) between the N-cite Heisenberg spin chain and a reduced gl(N) Gaudin model both at classical and quantum level. The former one appears on the gauge theory side of the AGT relation in the Nekrasov-Shatashvili (and further the Seiberg-Witten) limit while the latter one is natural on the CFT side. At the classical level, the duality transformation relates the Seiberg-Witten differentials and spectral curves via a bispectral involution. The quantum duality extends this to the equivalence of the corresponding Baxter-Schrodinger equations (quantum spectral curves). This equivalence generalizes both the spectral self-duality between the 2x2 and NxN representations of the Toda chain and the famous AHH duality.
Problem Reduction in Online Payment System Using Hybrid Model
Creators: name: Singh, Sandeep Pratap
name: Shukla, Shiv Shankar P.
name: Rakesh, Nitin
name: Tyagi, Vipin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Online auction, shopping, electronic billing etc. all such types of application involves problems of fraudulent transactions. Online fraud occurrence and its detection is one of the challenging fields for web development and online phantom transaction. As no-secure specification of online frauds is in research database, so the techniques to evaluate and stop them are also in study. We are providing an approach with Hidden Markov Model (HMM) and mobile implicit authentication to find whether the user interacting online is a fraud or not. We propose a model based on these approaches to counter the occurred fraud and prevent the loss of the customer. Our technique is more parameterized than traditional approaches and so,chances of detecting legitimate user as a fraud will reduce.
Thienemannimyia Fittkau 1957
Creators: name: Armitage, Brian J.
name: Andersen, Trond
name: Giłka, Wojciech
name: Castillo Sánchez, Kayla N.
name: Ríos González, Tomás A.
name: Aguirre, Yusseff P.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Thienemannimyia

description: Genus Thienemannimyia Fittkau, 1957
A genus of ~20 named species occurring in the Nearctic, Palaearctic, Afrotropical, and Oriental regions. Unnamed species were reported from Costa Rica by Watson & Heyn (1992). The larvae are found in both lotic and lentic waters (Cranston & Epler 2013).
description: Published as part of Armitage, Brian J., Andersen, Trond, Giłka, Wojciech, Castillo Sánchez, Kayla N., Ríos González, Tomás A. & Aguirre, Yusseff P., 2025, The Diptera of Panama. II. A first benchmark for the family Chironomidae, pp. 201-240 in Zootaxa 5613 (2) on page 230, DOI: 10.11646/zootaxa.5613.2.1, http://zenodo.org/record/15224174
What are the experiences of health service providers introducing alternative care pathways in a community setting?
Creators: name: SHANNON, BRENDAN PAUL
Publisher: name: Monash University
Year: 2023
Subjects: classificationCode: 320219
subject: Paramedicine

description: This thesis investigates health service providers' experiences of alternative care pathway programs, which aim to deliver healthcare in the community instead of a hospital, focusing on addressing the needs of complex patients. Key findings highlighted the need for tailored community healthcare and effective collaboration among healthcare providers, policymakers, and community organisations. Despite challenges, these programs showed promising outcomes, by focusing on providing health promotion and holistic care. Future research should assess healthcare utilisation impacts, patient experiences, and barriers to access. Implementing these patient-centred, resource-efficient pathways can help manage demands on the healthcare system, ultimately enhancing patient satisfaction and outcomes.
Wolfgang Dietrich Asmus 24.9.1908-13.2.1993
Creators: name: Redaktion, Die
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2020

description: -
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 71 Nr. 2 (1993)
title: Fragen über Fragen: Eine Untersuchung zum Frageverhalten von Schülerinnen und Schülern des 2. Zyklus in ästhetisch forschenden Unterrichtsformen
Creators: name: Kunz, Alexandra
Publisher: name: SUPSI
Year: 2022

description: Kinder verfügen über eine uneingeschränkte Bereitschaft, ihre Umgebung über das Fragen zu erkunden. In der Parallelität von ästhetisch handelnden Zugängen und kognitiven Verarbeitungsprozessen bauen sie an ihren Vorstellungen von Welt. Dieses Potenzial nutzt die Schule, wenn es darum geht, über subjektorientierte Unterrichtsformen aktuell beschriebene Bildungsziele zu erreichen. Im Fach Bildnerisches Gestalten werden in diesem Zuge Unterrichtsformen erprobt, welche sowohl das ästhetische Lernverhalten als auch den kindlichen Drang nach Welterkundung zu nutzen versuchen. Entsprechende Unterrichtskonzepte für höhere Stufen bilden hier eine Grundlage, wobei dem Fragen als Triebkraft für Lernen eine Schlüsselrolle zukommt. Überraschend ist, dass Aspekten des kindlichen Frageverhaltens insbesondere auf der Primarstufe im Rahmen von Kunstunterricht aus didaktisch-methodischer Sicht bisher kaum Beachtung geschenkt wird. Die qualitative Untersuchung 'Fragen über Fragen' bringt deshalb das Anliegen an, das Frageverhalten von Schülerinnen und Schülern des 2. Zyklus in forschenden Unterrichtssettings multiperspektivisch zu erfassen und dadurch Anhaltspunkte für die Entwicklung stufenadäquater, zeitgemässer Unterrichtsformen im Bildnerischen Gestalten zu gewinnen. Denn: wo das subjektiv bedeutsame Fragen unterstützt wird, können Lernprozesse in Gang treten. Das Datenmaterial, welches im Rahmen ästhetischer Forschungstätigkeiten von Primarschülerinnen und -schülern im Unterrichtsprojekt 'Kraut & Rüben' erhoben wird, bringt hervor, dass sich das kindliche Frageverhalten stufenspezifischer als erwartet gestaltet: Bemerkenswerte Ausprägungen sind u.a. in Aspekten des Zeitpunkts der Frageentwicklung, in den frageinitiierenden didaktischen Interventionen sowie in den kindlichen methodischen Vorgehensweisen rund um das Fragen zu finden. Die stufenspezifischen fachdidaktischen Konsequenzen, welche aus diesen Ergebnissen abgeleitet werden können, sind für die Planung und Durchführung einer ästhetisch forschenden Unterrichtspraxis von zentraler Bedeutung.
title: Народные традиции, промыслы и ремёсла в организации занятости сельских жителей
Creators: name: Дмитрук, Наталья
name: Дружнова, Маргарита
name: Гладких, Светлана
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: В содержании статьи констатируется актуальность для Новгородской области проблемы занятости сельского населения и её миграционного оттока в города. Целью работы является изучение в современный период вопроса организации в сельских населённых пунктах традиционных производств и использования местных
природных и историко-культурных особенностей как основы для музейных экспозиций. В статье приводятся примеры успешной организации малого бизнеса в сельской местности Новгородской области на основе использования народных традиций и промыслов как пути решения указанной проблемы. Авторы рассматривают
варианты организации занятости населения в условиях региона с богатым историческим наследием, традиционными промыслами, сформировавшимися на базе использования природных ресурсов. Результаты исследования отражают возможные направления развития сельских территорий региона.
It takes a system: Exploring new and disruptive systems of practice within the Anglo-American paramedic system
Creators: name: MAKRIDES, TIMOTHY
Publisher: name: Monash University
Year: 2023
Subjects: classificationCode: 320219
subject: Paramedicine

description: This thesis explores the structure and characteristics of modern Anglo-American paramedic systems and examines the factors that influence their design and how they relate to system performance. The study included seven peer-reviewed publications, including a narrative review of the history of paramedicine, a scoping review providing insight into the structure and characteristics of the paramedic system, and a survey evaluating the performance of two newly identified systems of practice: the Professionally Autonomous and Directive paramedic systems. Our thesis is designed to help paramedic systems improve system design for patients and paramedics alike, and its hoped that the roadmap for change contained within, acts as a catalyst for system modernization well into the future.
Skyscraper Scale: Structure Geometric Progression throughout the Centuries (Extended)
Creators: name: Ndoni, Albi
Publisher: name: Zenodo
Year: 2025

description: The Skyscraper Scale (Geometric Progression) is a conceptual framework for visualizing the progressive growth of skyscrapers across centuries, emphasizing the relationship between size, function, and technological advancement. Each level on the scale represents an exponential leap in height, width, and length, as well as the complexity of design and purpose.