cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Umwelt und Klima schützen - Wohnraum schaffen - Lebensqualität verbessern
Creators: name: Bartke, Stephan
name: Becken, Katja
name: Breitmeier, Maresa
name: Brozowski, Frank
name: DeTroy, Sarah Eileen
name: Grimski, Detlef
name: Ilvonen, Outi
name: Keßler, Hermann
name: Meilinger, Valentin
name: Messner, Dirk
name: Schlippenbach, Ulrike Von
name: Schlippenbach, Ulrike Von
name: Schröder, Alice
name: Schuberth, Jens
name: Schubert, Susanne
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Stadtentwicklung
subject: Umweltgerechtes Bauen
subject: Gebäudebestand
subject: Innenentwicklung
subject: Ressourcenerhaltung
subject: Schadstoffminderung
subject: wohnen
subject: Nachhaltiges Bauen
subject: Ressourcenschutz
subject: Wohnraum
subject: Bestandsumbau
subject: Klima | Energie
subject: Gesundheit
subject: Abfall | Ressourcen
subject: Nachhaltigkeit | Strategien | Internationales

description: Das Umweltbundesamt (UBA) und die Kommission Nachhaltiges Bauen am Umweltbundesamt (KNBau) haben Empfehlungen zur umwelt-, klima- und ressour-censchonenden und gleichzeitig klimaangepassten, gesundheits- und sozialverträglichen Schaffung bezahlbaren Wohnraums vorgelegt. Im Zentrum steht dabei der Umbau und die Umnutzung des Gebäudebestands, um die Ziele für Klima- und Ressourcenschutz im Gebäudesektor zu erreichen. Die Empfehlungen richten sich in erster Linie an die Bundespolitik mit den Ressorts für Bau- und Stadtentwicklung, Umwelt, Klimaschutz, Verkehr und Gesundheit. Darüber hinaus sind weitere Akteure angesprochen, wie politische Entscheidungs-träger*innen auf EU-, Landes- und kommunaler Ebene, Verbände, Planungspraxis und die Fachöffentlichkeit. Quelle: www.umweltbundesamt.de
description: Das Umweltbundesamt (⁠UBA⁠) und die Kommission Nachhaltiges Bauen am Umweltbundesamt (KNBau) haben Empfehlungen zur umwelt-, klima- und ressour­censchonenden und gleichzeitig klimaangepassten, gesundheits- und sozialverträglichen Schaffung bezahlbaren Wohnraums vorgelegt. Im Zentrum steht dabei der Umbau und die Umnutzung des Gebäudebestands, um die Ziele für ⁠Klima⁠- und Ressourcenschutz im Gebäudesektor zu erreichen.Die Empfehlungen richten sich in erster Linie an die Bundespolitik mit den Ressorts für Bau- und Stadtentwicklung, Umwelt, ⁠Klimaschutz⁠, Verkehr und Gesundheit. Darüber hinaus sind weitere Akteure angesprochen, wie politische Entscheidungs­träger*innen auf EU-, Landes- und kommunaler Ebe­ne, Verbände, Planungspraxis und die Fachöffentlich­keit.
FANTOM5 CAGE profiles of human and mouse samples
Creators: name: Noguchi, Shuhei
name: Arakawa, Takahiro
name: Fukuda, Shiro
name: Furuno, Masaaki
name: Hasegawa, Akira
name: Hori, Fumi
name: Ishikawa-Kato, Sachi
name: Babina, Magda
name: Guhl, Sven
name: Schulze-Tanzil, Gundula G.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Cell biology
subject: Computational biology and bioinformatics
subject: Developmental biology
subject: Molecular biology
subject: Systems biology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.
title: Imágenes radiológicas en tu iPad
Creators: name: Campos Álvarez, Carmen
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Computer Applications-Teleradiology
subject: Computer Applications-General
subject: Teleradiology
subject: PACS
subject: Computer applications

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
- Describir la capacidad del iPad como dispositivo portátil útil para el estudio de imágenes radiológicas. - Revisar las características de los principales visores de imágenes en formato DICOM para...
Exploring Food Neutrality in Home Economics Food and Nutrition Education
Creators: name: Wojakowski, Victoria
Publisher: name: The University of British Columbia
Year: 2025

description: This graduating paper explores the implementation of food-neutral practices within Manitoba’s grade 5 to 8 Food and Nutrition curriculum, focusing on how educators can create inclusive and non-judgemental food education environments. The inquiry addresses the question of how can food-neutral practices be incorporated into the curriculum to promote healthier relationships with food? Using content analysis, the curriculum language was examined for biases related to food, health, and body image. The findings reveal that while the curriculum is generally supportive of food-neutral practices, further intentional efforts are needed to ensure all food-related messages are inclusive and free from moral judgment. The analysis emphasizes the significant role educators play in shaping students’ relationships with food through language and classroom culture. The inquiry concludes that adopting food-neutral practices can create a more respectful, inclusive classroom environment, reduce food-related stigma, and enhance student well-being. Future research could explore classroom practices and student feedback to better understand the implementation and impact of food-neutral practices in education.
Oscillatory-flow and combined-flow bed forms: Experimental investigation and implications for the shallow marine rock record
Creators: name: Dumas, Simone
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Geology.

description: Long-period, storm-related oscillatory and combined-flows are thought to be responsible for much of the sand-sized sediment transport on the continental shelf. Yet, the relationship between these flow conditions and associated bed forms is still poorly understood. This study provides new experimental data aimed at characterizing equilibrium bed farms developed under long-period oscillatory and combined-flow conditions. Runs were conducted in a large combined-flow tunnel. Conditions explored were: oscillatory velocities (Uo) of 20--125 curls, unidirectional velocities (Uu) of 0--25 curls, oscillation period ( T) of 10.5 s and 8 s, and grain size of 0.14 mm and 0.22 mm. For conditions of increasing Uo the bed phases generated were: anorbital small-scale ripples (wavelength < 20 cm), orbital large-scale ripples (wavelength > 100 cm), and plane bed. For a given Uo and increasing Uu, the bed generally becomes progressively more asymmetric and is eventually planed flat. Hummocky bed forms developed under moderate oscillatory velocities (50 cm/s < Uo < 90 cm/s) and low unidirectional velocities (0 cm/s < Uu < 15 cm/s). "Synthetic" stratification generated by these hummocky bed forms exhibits many of the features of hummocky cross-stratification (HCS). For purely oscillatory flows conditions, the addition of a weak Uu (≥5 cm/s) causes the stratification to become anisotropic. For greater Uu (>10--12 cm/s) the resultant cross-stratification becomes similar to that produced by unidirectional-flow dunes. Potential genetic differences between HCS and swaley-cross stratification (SCS) were also investigated. Higher aggradation rates increased the preservation potential of hummocks which, as a consequence, increased the likelihood of forming HCS versus SCS. A cross-shelf depositional model is proposed in which HCS forms above storm wave base under moderate aggradation rates, whereas SCS forms at shallower depth under lower deposition/transport ratios resulting in lower aggradation rates. Results from these experiments suggest that HCS ad SCS are genetically linked to the hummocky bed forms generated under long period, oscillatory flows and oscillatory-dominant combined flows. As long-period, high-energy waves require deep, wide basins to form, HCS and SCS may therefore serve as useful indicators of deposition in unrestricted, open water conditions.
Diderot et la satire
Creators: name: Person, Alain
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Literature, Romance.

description: Nous connaissons l'écrivain Diderot, le philosophe, le directeur de l'Encyclopédie, l'esthéticien, voire le scientifique; sur un autre plan, Diderot auteur satirique demeurait, en grande partie, à découvrir. Nous nous proposons de montrer l'ampleur et la diversité des liens qui unissent Diderot à la satire en expliquant ce que représente la satire pour Diderot, en montrant dans quelle mesure et à quelles conditions Diderot est un auteur satirique, et de quelle manière il satirise. Après avoir défini la satire et après avoir rappelé ce que la notion recouvre historiquement comme genres et comme formes, nous étudions les sens que prend le terme chez Diderot et les rapports de celui-ci avec les auteurs satiriques canoniques. Nous abordons ensuite l'oeuvre satirique de Diderot selon trois axes. Entre l'abstraction et le réalisme le plus cru, l'auteur satirique possède une manière qui lui est propre de représenter son milieu. Dans cette perspective, nous analysons les représentations satiriques chez Diderot d'après les notions d'abstraction (allégories, rêves, animalisation), de monde inverse (l'utopie) et de théâtralisation du monde. Le deuxième axe de notre étude s'attache aux textes de fiction. Outre les poésies satiriques, nous examinons les oeuvres les plus connues de Diderot sous l'angle de l'esthétique comico-sérieuse (les Satires première et seconde), de la ménippée (Les Bijoux indiscrets, Jacques le Fataliste) et sous l'angle de la satire romanesque (La Religieuse). Le troisième et dernier volet de la thèse porte sur les pratiques polémiques (lettres ouvertes, apologies) et pamphlétaires de Diderot, ainsi que sur l'usage satirique qu'il fait du paradoxe.
Activation of the endothelin system in healthy and inflamed lungs: A mechanism for cardiovascular effects of air pollution
Creators: name: Thomson, Errol
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Health Sciences, Toxicology.
subject: Chemistry, Biochemistry.
subject: Biology, Physiology.

description: Circulating levels of the potent vasoconstrictor endothelin (ET) are increased after inhalation of urban pollutants. This effect could explain the association of air pollution and cardiovascular morbidity and mortality. However, the timing, source, and specific molecular basis of the increased endothelin release are not well defined. We hypothesized that inhalation of urban pollutants rapidly activates pulmonary endothelin system genes, resulting in increased production and spillover of the peptide into circulation. A time-course study confirmed rapid and transient increases of pulmonary preproET-1 and endothelin-converting enzyme-1 mRNA in rats exposed to particulate matter and ozone. Dose-response studies revealed that each pollutant individually activated endothelin system genes, consistent with the concomitant increase of the 21 amino acid peptide ET-1[1-21] and its precursor, bigET-1, in plasma. In contrast, pulmonary preproET-3 mRNA did not correlate with plasma ET-3 levels. Analyses in other organs revealed ozone-induced increases of endothelin gene expression in the brain, pituitary, and heart, substantiating the notion of extrapulmonary effects of pollutants. Surprisingly, co-exposure to particles and ozone increased pulmonary preproET-1 mRNA but not plasma ET-1[1-21] immediately after exposure. This coincided with an increase of matrix metalloproteinase-2, an enzyme that cleaves bigET-1 to ET-1 [1-32], suggesting that factors released during acute lung injury can modify circulating endothelin levels. To examine the effect of particle inhalation on existing lung pathology, we undertook microarray studies using SP-C/TNF-alpha mice with chronic lung inflammation and their wildtype littermates. Real-time PCR confirmed that inhalation of particles increased pulmonary preproET-1 and cytochrome p450 polypeptide 1 a1 mRNA, validating delivery of a biologically effective dose. Remarkably, microarray analyses failed to detect effects of particle exposure on pulmonary gene expression. Our data reinforce the notion that adverse health effects of acute exposure to urban particles may be dominated by physiological response cascades, with some transcriptional regulation such as activation of the endothelin pathway in target cells, rather than widespread changes in genes escaping homeostatic control. The rapid effects on a key vasoregulatory pathway in the lungs and brain provide a biological basis to explain the acute cardiovascular and cerebrovascular events that occur within hours of increased levels of air pollution.
Study of Slag Structure and its Correlation to the Distribution Ratio of Gallium (Ga) in Conditions relevant to Processing of E-waste through Black Copper Smelting
Creators: name: Hasan, Mohammad Mehedi
Publisher: name: Swinburne
Year: 2024

description: In this thesis, the structure of the coppermaking slags and its correlation to the distribution ratio of Gallium (Ga) relevant to black copper smelting are studied. High temperature experiments were carried out at different slag chemistry, temperature and oxygen partial pressure to study the slag structures and distribution ratio of Ga in Fe2O3-CaO-SiO2 (FCS) slag to copper and also to study the correlation between them. Finally, the slag design criteria for the optimum recovery of valuable elements through black copper smelting process is suggested. These are important for both the fundamental understanding and industrial recovery of valuable elements from E-waste.
Discrete-time RAKE receivers with applications
Creators: name: Baykas, Tuncer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: Wireless channels are often multipath channels. In a multipath channel, a path can be defined as a copy of the transmitted signal arriving at the receiver with a particular delay and amplitude. If the multipaths are resolvable, RAKE receivers can collect the energy of distinct paths. DS-CDMA systems, with their low auto-correlation spreading sequences, enable resolving of the multipaths and therefore the use of RAKE reception. Each RAKE finger, the elementary receiver in RAKE reception, is associated with one of the strongest incoming paths. The outputs of those fingers are combined together to detect the transmitted symbols. The conventional RAKE receivers have several weaknesses. This thesis focuses on the major weaknesses of sensitivity to interference and channel estimation error. It introduces a receiver model to cope with both of them for both single and multi antenna (MIMO) systems. We propose a new RAKE reception method, which is called the generalized decorrelating RAKE receiver (GD-RAKE). GD-RAKE is obtained by the combination of two advanced RAKE receivers: the decorrelating discrete time RAKE receiver (D-DTR) and the generalized RAKE receiver (G-RAKE). The method enables robust performance in the presence of channel estimation errors and colored noise plus interference with the help of statistics on the channel, noise and interference. Additionally the performance of the new receiver is tested in MIMO channels. Soon to be commercialized ultra wideband (UWB) systems use more than 500 MHz bandwidth. Such a high bandwidth results in many resolvable multipaths and as such the employment of RAKE receivers is very suitable. We tested the performance of a G-RAKE receiver with decision feedback equalizers and showed that it can be used to improve overall performance of the system.
Molecular characterization of the cell division gene ftsZ in Neisseria gonorrhoeae.
Creators: name: Radia, Avni.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Molecular.

description: Cell division is an essential process in all bacteria, although in some organisms like Neisseria gonorrhoeae relatively little is known about cell division. The process has been well characterized in Escherichia coli, with the identification and characterization of many cell division genes. The ftsZ gene is essential in E. coli as the gene product plays a critical role in the initiation and formation of the septum at the division site. In efforts to understand cell division at the molecular level in N. gonorrhoeae, the ftsZ gene has been identified and preliminary characterization is reported. The gonococcal ftsZ consists of a 1179 bp open reading frame, encoding a 41.3 kDa protein. Sequence analysis has shown the gonococcal FtsZ to be highly similar to other known FtsZ proteins, with conservation of the GTP binding motif. In vitro transcription/translation shows the gene encodes a protein migrating at 43 kDa. Western blot analysis of gonococcal lysates and commensal Neisseria lysates detected an immunoreactive band using an anti-E. coli FtsZ antisera. Attempts to clone the gonococcal ftsZ gene in an E. coli host indicate that expression of the gene from a putative native promoter is lethal to the cell. When expression is controlled by an inducible lactose promoter, the E. coli cells show a filamentous phenotype similar to that seen with expression of other heterologous ftsZ genes. Attempts to knock out the ftsZ gene on the gonococcal chromosome by transformation and recombination indicate that the gene is essential in N. gonorrhoeae. The initial characterization of the ftsZ gene in N. gonorrhoeae provides a basis for further study of cell division in this organism.
Substructure analysis of selected low-richness 2dFGRS clusters of galaxies
Creators: name: Burgett, William S.
name: Vick, Michael M.
name: Davis, David S.
name: Colless, Matthew
name: De Propris, Roberto
name: Baldry, Ivan
name: Baugh, Carlton
name: Bland-Hawthorn, Joss
name: Bridges, Terry
name: Cannon, Russell
name: Cole, Shaun
name: Collins, Chris
name: Couch, Warrick
name: Cross, Nicholas
name: Dalton, Gavin
name: Driver, Simon
name: Efstathiou, George
name: Ellis, Richard
name: Frenk, Carlos S.
name: Glazebrook, Karl
name: Hawkins, Edward
name: Jackson, Carole
name: Lahav, Ofer
name: Lewis, Ian
name: Lumsden, Stuart
name: Maddox, Steve
name: Madgwick, Darren
name: Norberg, Peder
name: Peacock, John A.
name: Percival, Will
name: Peterson, Bruce
name: Sutherland, Will
name: Taylor, Keith
Publisher: name: Swinburne
Year: 2024

description: Complementary one-, two- and three-dimensional tests for detecting the presence of substructure in clusters of galaxies are applied to recently obtained data from the 2dF Galaxy Redshift Survey. The sample of 25 clusters used in this study includes 16 clusters not previously investigated for substructure. Substructure is detected at or greater than the 99 per cent confidence level in at least one test for 21 of the 25 clusters studied here. From the results, it appears that low-richness clusters commonly contain subclusters participating in mergers. About half of the clusters have two or more components within 0.5 h(-1) Mpc of the cluster centroid, and at least three clusters (Abell 1139, Abell 1663 and Abell S333) exhibit velocity-position characteristics consistent with the presence of possible cluster rotation, shear, or infall dynamics. The geometry of certain features is consistent with influence by the host supercluster environments. In general, our results support the hypothesis that low-richness clusters relax to structureless equilibrium states on very long dynamical time-scales (if at all).
On the Origin of Morphological Structures of Planetary Nebulae
Creators: name: Kwok, Sun
Publisher: name: The University of British Columbia
Year: 2018

description: We suggest that most of the mass in planetary nebulae (PNe) resides in the equatorial region and the spherical envelope and the optically bright lobes of PNe are in fact low-density cavities cleared out by fast outflows and photoionized by UV photons leaked from the torus. The nature of multi-polar PNe is discussed under this framework.
The potential role of protein kinase B in 3T3-L1 adipocyte differentiation.
Creators: name: Magun, Rick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Cell.

description: The downstream targets of insulin/IGF-1 that lead to adipocyte differentiation appear to include the PI 3-kinase/p70 S6 kinase pathway. Recently several laboratories have shown that protein kinase B (PKB), an insulin-responsive serine/threonine kinase, is a direct target of PI 3-kinase and can activate p70 S6 kinase. The present study examines the potential role of PKB in insulin/IGF-1-dependent adipocyte differentiation. We have shown that PKB is expressed in 3T3-L1 preadipocytes, and that it is stimulated by insulin. The involvement of PI 3-kinase and p70 S6 kinase in adipocyte differentiation suggests that PKB may link PI 3-kinase to p70 S6 kinase signals. We have tested whether PKB is sufficient for 3T3-L1 preadipocyte differentiation. A version of PKB that is constitutively activated by linkage to the viral gag gene (Gag-PKB) was expressed in 3T3-L1 preadipocytes and shown to induce spontaneous differentiation in the absence of added insulin/IGF-1. The cells assumed a spherical shape and they acquired characteristic lipid droplets that stained positively for the neutral lipid stain, Oil Red O. Northern blot analysis demonstrated upregulation of LPL and aP2 mRNA, specific indicators of adipocyte differentiation. A plasmid vector, in which Gag-PKB was placed under the control of the glucocorticoid-responsive MMTV promoter, was then expressed in 3T3-L1 preadipocytes. When Gag-PKB expression was induced by dexamethasone, spontaneous differentiation followed, despite the absence of insulin/IGF-1. These results suggest that the genetic program of adipocyte differentiation is subject to regulation by PKB. Inducible expression of Gag-PKB will permit the generation of stable cell lines to further explore the role of PKB in adipocyte differentiation.
title: Ableitung sicherer Trendaussagen zur Entwicklung der Luftqualität in Deutschland
title: Ableitung sicherer Trendaussagen zur Entwicklung der Luftqualität in Deutschland
titleType: AlternativeTitle
Creators: name: Schmidtke, Jörg
name: Schmidt, Kerstin
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: subject: Ozon
subject: Stickstoffdioxid
subject: PM10
subject: Feinstaub
subject: NO2
subject: Luft

description: Zur Beurteilung der Trends der Luftschadstoffe Ozon, Stickstoffdioxid (NO2) und Feinstaub (PM10) in Deutschland standen räumlich und zeitliche inhomogene Messnetze zur Verfügung. Die Inhomogenitäten beruhten einerseits auf der ungleichmäßigen geografischen Verteilung und andererseits auf der Schließung, Neueinrichtung oder zwischenzeitlichen Außerbetriebnahme von Messstationen. Im Rahmen dieses Projektes wurde eine Methodik entwickelt, die unter Berücksichtigung der Inhomogenitäten, die Trends der Luftschadstoffe Ozon, NO2 und PM10 zuverlässig berechnet. Mit Hilfe dieser Methode wird zunächst eine Mittelwertzeitreihe geschätzt und danach durch lineare Regression der Trend bestimmt. Die Schätzung der Mittelwertzeitreihe erfolgt durch einen Differenzialgleichungsansatz. Diese Methode wurde in einem R-Programm umgesetzt und kann auch für andere Luftschadstoffe, die sich ähnlich wie Ozon, NO2 und PM10 verhalten, verwendet werden. Quelle: Forschungsbericht
description: To assess trends of the air pollutants ozone, nitrogen oxide (NO2) and particulate matter (PM10) in Germany, spatially and temporally inhomogeneous monitoring networks were available. The inhomogeneity was caused both by irregular geographic distribution and closure, new installation or decommissioning of monitoring stations. Within the context of this project, a method was developed to reliably calculate trends of the air pollutants ozone, NO2 and PM10 by taking into account data inhomogeneity. This method estimates a mean times series and determines the trend by linear regression. Mean time series are estimated by a differential equation approach. This method was implemented in an R program and also can be applied to other air pollutants developing comparably to ozone, NO2 and PM10. Quelle: Forschungsbericht
description: Zur Beurteilung der Entwicklung der Luftqualität in Deutschland stehen Daten aus räumlich und zeitlich inhomogenen Messnetzen der 16 Bundesländer und des Umweltbundsamtes zur Verfügung. Damit ist es problematisch, sichere Trendaussagen zur kurz- und langfristigen Entwicklung der Luftqualität zu treffen, die als repräsentativ für Deutschland angesehen werden können. Im Rahmen des Projektes wurde eine Methodik entwickelt werden, mit der sichere Aussagen zu den mittleren Trends (verkehrsnah, städtischer Hintergrund, ländlicher Hintergrund, industrienah) für die Luftschadstoffe Ozon, Stickstoffdioxid und Feinstaub getroffen und objektiv beurteilt werden können.
Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes
Creators: name: Ebstein, F.
name: Textoris-Taube, K.
name: Keller, C.
name: Golnik, R.
name: Vigneron, N.
name: Van Den Eynde, B. J.
name: Schuler-Thurner, B.
name: Schadendorf, D.
name: Lorenz, F. K. M.
name: Uckert, W.
name: Urban, S.
name: Lehmann, A.
name: Albrecht-Koepke, N.
name: Janek, K.
name: Henklein, P.
name: Niewienda, A.
name: Kloetzel, P. M.
name: Mishto, M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Proteasome-catalyzed peptide splicing represents an additional catalytic activity of proteasomes contributing to the pool of MHC-class I-presented epitopes. We here biochemically and functionally characterized a new melanoma gp100 derived spliced epitope. We demonstrate that the gp100mel47–52/40–42 antigenic peptide is generated in vitro and in cellulo by a not yet described proteasomal condensation reaction. gp100mel47–52/40–42 generation is enhanced in the presence of the β5i/LMP7 proteasome-subunit and elicits a peptide- specific CD8+ T cell response. Importantly, we demonstrate that different gp100mel-derived spliced epitopes are generated and presented to CD8+ T cells with efficacies comparable to non-spliced canonical tumor epitopes and that gp100mel-derived spliced epitopes trigger activation of CD8+ T cells found in peripheral blood of half of the melanoma patients tested. Our data suggest that both transpeptidation and condensation reactions contribute to the frequent generation of spliced epitopes also in vivo and that their immune relevance may be comparable to non-spliced epitopes.
Advancing the State-of-the-Art of Lithium Sulfur Batteries
Creators: name: Ramezanitaghartapeh, Mohammad
Publisher: name: Swinburne
Year: 2024

description: Mohammad’s PhD project was on sustainable developments of electrode materials for use in next generation lithium-sulfur batteries. He worked on the design and modeling of functionalised carbon materials for the preparation of free-standing cathodes using conjugated microporous polymers. This included characterising the electrochemical performance of prototype batteries based on their charging and discharging efficiency. He is also a winner of the German Federal Ministry of Education and Research Green Talents Award in 2019 for his proposal on all-organic-battery technology.
Re-Imagining Culinary Arts Education : Beyond the Apprenticeship Model
Creators: name: Jonas, Adam Carl
Publisher: name: The University of British Columbia
Year: 2025

description: This paper examines the evolution of Culinary Arts education in British Columbia, with a focus on historical, cultural, and pedagogical shifts. It critiques traditional culinary models, particularly the master-apprentice structure, and advocates for a more holistic, inclusive approach that integrates critical thinking, cultural awareness, and social-emotional learning. Through personal reflection and academic inquiry, the paper calls for a transformative framework that balances technical skills with critical inquiry, sustainability, and social responsibility. It emphasizes the importance of strong teacher-student relationships and the need for curricula that prepare students to navigate the complexities of the modern world. This study also explores the role of Critical Literacy in reshaping teaching and learning by encouraging students to critically engage in food systems, challenge societal inequities, and explore the ethical, political, and environmental dimensions of food. Drawing on transformative education principles, this conceptual analysis, historical inquiry advocates for a curriculum that empowers students to reflect on their practices and contribute to more equitable and sustainable food systems. Just as mise en place organizes a chef’s kitchen, a critical literacy approach serves as an organizational tool to refine both pedagogical practices and students' learning potential.
title: Contractura congénita en abducción de cadera.
Creators: name: Torres Isidro, María Victoria
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Dysplasias
subject: Congenital
subject: Paediatric

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar los hallazgos radiológicos que deben hacernos sospechar una contractura congénita en abducción de...
A N.M.R. spectrometer for Knight shift investigations.
Creators: name: Prakash, Virendra.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1960
Subjects: subject: Physics, Electricity and Magnetism.

description: This thesis describes the design, assembly, operation and behaviour of a nuclear magnetic resonance spectrometer of the Pound-Knight type built for investigation of Knight shift in metals and alloys. A brief introduction to nuclear magnetic resonance is given followed by a short discussion of the Knight shift. A short description of the various arrangements for observing nuclear magnetic resonance is given and after pointing out the requirements for observing the Knight shift in metals, our choice of the spectrometer is justified. The working of the spectrometer as a whole unit is explained and this is followed by a description of its various components. The technique of determining frequency is described in detail by giving a typical example of A127 signal from a solution of AlCl3. The behaviour of the spectrometer is discussed and its use in detection of various signals is given. The necessary conditions for obtaining good signals are summarised. The temperature variation and also the homogeneity of the magnetic field are studied with the aid of the spectrometer. The accuracy and usefulness of the equipment is tested by measuring the Knight shift in aluminium metal.
Potentiale und Kernergebnisse der Simulationen von Ressourcenschonung(spolitik)
Creators: name: Hirschnitz-Garbers, Martin
name: Distelkamp, Martin
name: Koca, Deniz
Publisher: name: My University
Year: 2018
Subjects: subject: Ressourcenpolitik
subject: Ressourcennutzung
subject: Tendanalyse
subject: Szenarien
subject: ökonometrische Modellierung
subject: systemische Modellierung
subject: Ressourceninanspruchnahme
subject: Verfügbarkeiten
subject: Nachhaltigkeit | Strategien | Internationales

description: Im Projekt SimRess wurden die potentiellen Auswirkungen zukünftiger ressourcenpolitisch relevanter Entwicklungen und Strategien auf wichtige Umwelt- und Wirtschaftsindikatoren getestet. Mittels einer Trendanalyse wurden zunächst Entwicklungen identifiziert, die zukünftig positiv wie negativ Einfluss auf die Nutzung natürlich Ressourcen in Deutschland und global nehmen könnten. Diese Entwicklungen wurden dann in unterschiedliche Szenarien eingebettet, die als Rahmen für die Simulation potentieller Auswirkungen im ökonometrischen Modell GINFORS3 und im systemdynamischen Modell WORLD6 sowie in einem soft-link beider Modelle dienten.
DNA ploidy and morphology of colon tumors in the adenoma - carcinoma sequence
Creators: name: Staarmann, Judith
name: Kotb, Waleed F. A.
name: Petersen, Iver
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction. Chromosomal changes are widespread in the vast majority of colon carcinomas and aneuploidy is an established prognostic factor. However, this knowledge so far has no influence on tumor classification. We reported a morphology-based classification scheme, the core classification, that correlates with DNA ploidy. In particular, tripolar mitoses were identified as surrogate markers of a near triploid DNA content. In addition, a survey on chromosome numbers and survival rates in carcinomas suggested that triploidy as a particular state of aneuploidy may be correlated with a more aggressive tumor phenotype. We therefore aimed to analyse DNA ploidy in the colorectal adenoma–carcinoma sequence. Material and methods. The study collection consisted of 15 adenomas and 15 adenocarcinomas of 10 patients. Some of them showed a morphological transition between benign and malignant tumor components which were selectively analysed by DNA measurements. In addition, we assessed the morphological parameters of the core classification. Results. The main findings of the study may be summarized as follows. 1) DNA ploidy changes are already consistently detectable in colon adenomas. They are usually associated with hyperdiploidy. 2) Adenoma tissue adjacent to carcinomas, however, may carry a hypodiploid DNA content while the nearby carcinoma samples were hyperdiploid. Hypodiploidy may thus represent a transition state to near triploid carcinomas. 3) The size of tumor nuclei and mitoses usually reflects the ploidy level of colon tumors. Specifically, triploid mitoses may point to a near triploid DNA content. 4) Triploidy per se cannot be equated with tumor aggressiveness as it may already be found in adenocarcinoma in situ. 5) Tripolar and tetrapolar mitoses in invasive colon cancer, however, are potential indicators of an advanced chromosomal instability and seemed to be associated with advanced tumor stages. Conclusions. We present data that hypodiploidy may represent a transition state from adenoma to carcinoma in a subset of colorectal tumors and that near-triploidy may be associated with a more aggressive course of the disease. However, the interpretation of tripolar mitoses and triploidy is largely dependent on the cell type (benign vs. malignant) and tissue context (invasive vs. non-invasive cancer). Furthermore, its interpretation may be distinct for different tumor stages and histotypes. Aneuploidy and multipolar mitoses are frequent findings in cancer cells. Their relevance for tumor biology deserves further studies.
Part I. The structure of lyconnotine. Part II. Studies of some derivatives of cyclohexane. Part III. Studies of some derivatives of bicyclo[2.2.1]heptane.
Creators: name: Haq, Mohammad Zamir-Ul.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1967
Subjects: subject: Chemistry, Organic.

description: Part I. Lyconnotine, an alkaloid of Lycopodium annotinum L. has been isolated by an improved method. Isolation of a derivative of lyconnotine has also been accomplished. The structure and stereochemistry of these alkaloids have been established on the basis of chemical and spectral evidence. Attempts to interrelate acrifoline and dihydro-acrifoline to lyconnotine by photochemical cleavage of the former two alkaloids have been unsuccessful. On photolysis, a complicated mixture of a number of components is obtained. It has been shown that the major photoproducts cannot be readily converted to lyconnotine. Part II. The preparation of (i) cyclohexane- cis-3,3,4,5,6,6-d6, (ii) cis-1,2-dicarbomethoxy cyclohexane-cis-3,3,4,5,6,6-d6, and (iii) cyclohexane-3,3,6,6-d 4 has been achieved. The N.M.R. spectra of these compounds at ambient and lower temperatures are discussed and various kinetic parameters for conformational changes in cyclohexene have been obtained. Values of the coupling constants in cyclohexane are furnished. Part III. The syntheses of a number of 7-substituted bicyclo[2.2.1]heptane derivatives are described. Representative compounds include 7-isopropylidene bicyclo[2.2.1]hept-5-ene-exo-2,3-diol carbonate Ia, the corresponding endo isomer Ib, exo-2,3-dihydroxy-7-isopropylidene bicyclo[2.2.1]hept-5-ene IIa, the corresponding endo diol IIb, 7-isopropylidene bicyclo[2.2.1]hept-5-ene- exo-2,3-diol thionocarbonate, IIIa and its endo counterpart IIIb. Products of catalytic reduction of compounds Ia, IIa and IIIa have also been obtained. Configurations of these compounds have been established on the basis of their N.M.R. spectra. Attempts to obtain 7-isopropylidene bicyclo[2.2.1]hepta-2,5-diene have been unsuccessful. The anisotropic effect of the double bond in the above series and in the 7,7-dimethylene bicyclo[2.2.1]heptane derivatives is discussed and compared with the previous results in the literature.
Evaluation der ökologischen und ökonomischen Auswirkungen des Wegfalls der Heizwertregelung des § 8 Abs. 3 Satz 1 KrWG
Creators: name: Zotz, Ferdinand
name: Weißenbacher, Jakob
name: Dollhofer, Marie
Publisher: name: My University
Year: 2016
Subjects: subject: Abfall
subject: Abfallhierarchie
subject: Abfallverbrennung
subject: Abfallrecht
subject: Kreislaufwirtschaftsgesetz
subject: Abfall | Ressourcen
subject: Waste | Resources

description: Das Ziel des Vorhabens war, die ökologischen und ökonomischen Auswirkungen eines Wegfalls der Heizwertregelung für 19 Abfallströme zu evaluieren. Dabei wurde unter Berücksichtigung der aktuellen Entsorgungssituation insbesondere untersucht, inwieweit eine Streichung der Heizwertklausel Auswirkungen auf die Pflichtenstellung der relevanten Abfallerzeuger und -besitzer hätte. Der für die Wirtschaft, die öffentliche Verwaltung sowie für Bürgerinnen und Bürgern entstehende Erfüllungsaufwand für den Fall der Streichung der Heizwertklausel wurde mit der Standardmethodik der Gesetzesfolgenabschätzung ermittelt.
title: Biopsia Selectiva del Ganglio Centinela en el cáncer de mama. Eficacia ténica. Fases de aprendizaje y aplicación clinica.
Creators: name: Torres Sousa, María Yolanda
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Technology assessment
subject: Outcomes analysis
subject: Ultrasound
subject: Mammography
subject: Lymphography
subject: Breast

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Estudio prospectivo de pacientes tratadas de cáncer de mama y con biopsia selectiva del ganglio centinela (BSGC),
analizando estándares de calidad de la técnica en las fases de “validación” y de “aplicación...
Characterisation of Tri-Block Co-Polymer Graphene Systems Produced using Surfactant-Assisted Liquid-Phase Exfoliation: Instrumental Analysis, Aggregation and Adsorption
Creators: name: Strathie, Christopher Henry
Publisher: name: Swinburne
Year: 2024

description: Since its isolation in 2004, graphene has gained an enormous amount of attention throughout the scientific community due to its exceptional material properties. This thesis aimed to synthesis and characterise a series of polymer stabilised pristine graphene materials through systematic instrumental analysis to ascertain key properties and stability. These high surface area materials were then assessed for their ability to adsorb and remove potentially harmful substances from water. This analysis brings to light several strengths and weaknesses of graphene as an adsorbent and this knowledge will greatly benefit future water treatment strategy development.
title: EnteroRM en la Enfermedad de Crohn para principiantes: Cómo realizar un estudio adecuado y evitar los errores iniciales
Creators: name: Lasarte Izcue, Aitor
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Inflammation
subject: Fistula
subject: Diagnostic procedure
subject: MR
subject: Small bowel
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Implantación de un adecuado protocolo de EnteroRM: ¿Por dónde empiezo? Familiarizarse con los signos de inflamación activa y las complicaciones de la Enfermedad de Crohn Tratar de explicar los errores iniciales que pueden suponer una...
title: Ablación mediante RF percutánea de tumores renales con control radiológico.
Creators: name: Ponce Dorrego, María Dolores
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Kidney
subject: Interventional non-vascular
subject: Abdomen

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Realizar una revisión de las radiofrecuencias renales percutáneas con control radiológico realizadas en nuestro...
Das Menschenrecht auf Wasser als Allokationsproblem
Creators: name: Bretschneider, Wolfgang
Publisher: name: My University
Year: 2017
Subjects: Trinkwasserversorgung
Trinkwasser
Menschenrecht

description: Wie gelingt die Umsetzung eines Menschenrechts auf Wasser? Sie gelingt nur, wenn eine Trinkwasserpolitik zugleich auch in ökologischer und ökonomischer Hinsicht nachhaltig ist. Wolfgang Bretschneider skizziert auf dieser Grundlage einen institutionenökonomisch geprägten Begriff der Versorgungsgerechtigkeit, mit dem ein Spannungsfeld beschrieben wird. Denn ein privater Haushalt ist in seiner Wassernutzung nicht nur Träger eines Anspruchs, sondern umgekehrt auch Träger von Verantwortung gegenüber Umwelt und Gesellschaft. Nur wenn dies berücksichtigt wird, ist auch seine eigene Wasserversorgung langfristig gesichert. Im Zentrum des Buchs steht daher eine Konturierung des "schmalen Grats" zwischen Nutzungsanspruch und -verantwortung, die gerade auch auf Fragen des Wasserpreises angewandt wird. Quelle: Verlagsinformation
title: Structural Alterations of the Social Brain
title: A Comparison between Schizophrenia and Autism
titleType: Subtitle
Creators: name: Radeloff, Daniel
name: Ciaramidaro, Angela
name: Siniatchkin, Michael
name: Hainz, Daniela
name: Schlitt, Sabine
name: Weber, Bernhard
name: Poustka, Fritz
name: Bölte, Sven
name: Walter, Henrik
name: Freitag, Christine Margarete
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in brain structure. In this voxel based morphometry study, 34 patients with autism spectrum disorder, 21 patients with schizophrenia and 26 typically developed control subjects were included to identify global and regional brain volume alterations. No global gray matter or white matter differences were found between groups. In regional data, patients with autism spectrum disorder compared to typically developed control subjects showed smaller gray matter volume in the amygdala, insula, and anterior medial prefrontal cortex. Compared to patients with schizophrenia, patients with autism spectrum disorder displayed smaller gray matter volume in the left insula. Disorder specific positive correlations were found between mentalizing ability and left amygdala volume in autism spectrum disorder, and hallucinatory behavior and insula volume in schizophrenia. Results suggest the involvement of social brain areas in both disorders. Further studies are needed to replicate these findings and to quantify the amount of distinct and overlapping neural correlates in autism spectrum disorder and schizophrenia.
Exploring the interaction of environmental and genetic factors on the development of depressive symptomatology in an animal model
Creators: name: Konkle, Anne T. M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Psychology, Clinical.
subject: Psychology, Experimental.

description: Major depressive disorder is a devastating disease characterized by intense and prolonged sadness and feelings of hopelessness and worthlessness. While developments in drug therapy have provided some insight into the mechanisms underlying depression, investigations employing animal models have provided another strategy for studying the neurobiology of depression. The first generation of these models evolved to evaluate the therapeutic potential of novel drugs, and included the reserpine reversal test, forced swimming test, and the brain-stimulation reward (BSR) procedure. The rationale in the case of the latter was that since one of the core symptoms of depression is a decreased capacity to experience pleasure, interventions that relieve these symptoms in humans will enhance reward transmission; in animals, this was interpreted from decreases in thresholds for BSR. In the first experiment, we evaluated the effects of paroxetine, an antidepressant of the selective serotonin reuptake inhibitor class, on BSR thresholds and observed only modest decreases in thresholds. These results mimicked the minimal mood altering effects that antidepressants are reported to have in "normal" individuals. Next, as a means of inducing a depressive state in rats, the chronic mild stress (CMS) procedure, developed to model anhedonia, a core symptom of depression, was employed in the subsequent experiments. Its consequences were measured on several indices of depressive behaviours, sucrose consumption (1 and 24h intake and preference), BSR thresholds, and the forced swim test. Genetic variation was considered by comparing male and female rats of two outbred strains. While CMS produced little change in BSR thresholds, its effects on sucrose consumption were varied; in male rats, we observed an initial reduction in 1h sucrose intake in Long Evans exclusively, while a CMS-induced reduction on the 24h intake measure was evident in both strains of female rats, with a greater effect in the Sprague-Dawley group. In evaluating the effects of CMS on forced swimming behaviour, we saw no group or strain difference in the female rats and a notable strain difference in male rats. Long Evans animals with a history of stress significantly reduced the duration of the test engaged in escape-type behaviours on the second exposure to forced swim, as would be expected in animals experiencing learned helplessness, a behaviour characteristic of depressed individuals. (Abstract shortened by UMI.)