cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ACUTE KIDNEY INJURY IN PATIENTS TREATED WITH VANCOMYCIN AND PIPERACILLIN-TAZOBACTAM
A RETROSPECTIVE COHORT ANALYSIS
Creators: name: Rutter, Wilbur Cliff
Publisher: name: University of Kentucky
Year: 2016
Subjects: subject: Other Pharmacy and Pharmaceutical Sciences

description: Empiric antimicrobial therapy often consists of the combination of Gram-positive coverage with vancomycin (VAN) and Gram-negative coverage, specifically an anti-pseudomonal beta-lactam, such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports demonstrate increasing nephrotoxicity rates among patients treated with the combination of VAN and PTZ. This study evaluated the effect of the VAN/PTZ combination on acute kidney injury (AKI), as defined by the RIFLE criteria, compared to VAN and PTZ monotherapies.  Overall, 11,650 patients were analyzed, with 1,647 (14.1%) AKI cases occurring. AKI was significantly more frequent in the VAN/PTZ group (21%) compared to either monotherapy group (VAN 8.3%, PTZ 7.8%, p  VAN combined with PTZ was associated with twice the odds of AKI development compared to either agent as monotherapy. This demonstrates the need for judicious use of combination empiric therapy.
title: Promoting Healthy Eating and Physical Activity
title: A Qualitative Examination of Community-Based Obesity Interventions in Rural Kentucky
titleType: Subtitle
Creators: name: Butterworth, Brooke F.
Publisher: name: University of Kentucky
Year: 2016
Subjects: subject: International and Community Nutrition
subject: Nutritional Epidemiology
subject: Public Health Education and Promotion

description: Rural Americans are medically underserved groups and are at greater risk of becoming obese than urban Americans. The purpose of this qualitative study was to determine the perceived causes of obesity in six counties of rural Kentucky and to determine how to customize strategies to reduce obesity in these areas. University of Kentucky Cooperative Extension Service Agents formed coalitions in each of the six counties to assess their communities’ needs and assets to inform plans for implementing evidence-based obesity interventions. Between February and August of 2015, the coalitions were convened for a total of 11 meetings. Each of the coalition meetings was audio recorded, transcribed, and coded using NVivo 11 qualitative analysis software. Coalition members in these rural counties of Kentucky recognized aspects of their culture, poor dietary choices, and inactivity as the major reasons obesity is a problem in their county. Participants reported high prevalence of fast food restaurants, lack of access to healthy foods and physical activity resources, technology, and lack of time as barriers to healthy behaviors. These findings provide insight to inform tailored, evidence-based interventions for rural communities. Improving access to healthy foods and physical activity resources in rural areas may improve healthy behaviors and reduce obesity prevalence.
A Quantum-Classical Model of Brain Dynamics
Creators: name: Sergi, Alessandro
name: Messina, Antonino
name: Vicario, Carmelo M.
name: Martino, Gabriella
Publisher: name: arXiv
Year: 2023
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Quantum Physics (quant-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences
subject: 01-00, 81-03, 92C05, 92C20

description: The study of the human psyche has elucidated a bipartite structure of cognition reflecting the quantum-classical nature of any process that generates knowledge and learning governed by brain activity. Acknowledging the importance of such a finding for modelization, we posit an approach to study brain by means of the quantum-classical dynamics of a Mixed Weyl symbol. The Mixed Weyl symbol is used to describe brain processes at the microscopic level and provides a link to the results of measurements made at the mesoscopic scale. Within this approach, quantum variables (such as,for example, nuclear and electron spins, dipole momenta of particles or molecules, tunneling degrees of freedom, etc may be represented by spinors while the electromagnetic fields and phonon modes involved in the processes are treated either classically or semi-classically, by also considering quantum zero-point fluctuations. Zero-point quantum effects can be incorporated into numerical simulations by controlling the temperature of each field mode via coupling to a dedicated Nosè-Hoover chain thermostat. The temperature of each thermostat is chosen in order to reproduce quantum statistics in the canonical ensemble. In this first paper, we introduce a quantum-classical model of brain dynamics, clarifying its mathematical strucure and focusing the discussion on its predictive value. Analytical consequences of the model are not reported in this paper, since they are left for future work. Our treatment incorporates compatible features of three well-known quantum approaches to brain dynamics - namely the electromagnetic field theory approach, the orchestrated objective reduction theory, and the dissipative quantum model of the brain - and hints at convincing arguments that sustain the existence of quantum-classical processes in the brain activity. All three models are reviewed.
description: Submitted to Entropy [MDPI], Special Issue "Quantum Processes in Living Systems"
Repetitive Head Impact Exposure in College Football Following an NCAA Rule Change to Eliminate Two-A-Day Preseason Practices: A Study from the NCAA-DoD CARE Consortium
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: Sport-related concussion
Injury biomechanics
Traumatic brain injury
Acceleration

description: © 2019, The Author(s). Repetitive head impact exposure sustained by athletes of contact sports has been hypothesized to be a mechanism for concussion and a possible explanation for the high degree of variability in sport-related concussion biomechanics. In an attempt to limit repetitive head impact exposure during the football preseason, the NCAA eliminated two-a-day practices in 2017, while maintaining the total number of team practice sessions. The objective of this study was to quantify head impact exposure during the preseason and regular season in Division I college football athletes to determine whether the 2017 NCAA ruling decreased head impact exposure. 342 unique athletes from five NCAA Division I Football Bowl Subdivision (FBS) programs were consented and enrolled. Head impacts were recorded using the Head Impact Telemetry (HIT) System during the entire fall preseasons and regular seasons in 2016 and 2017. Despite the elimination of two-a-day practices, the number of preseason contact days increased in 2017, with an increase in average hourly impact exposure (i.e., contact intensity), resulting in a significant increase in total head impact burden (+ 26%) for the 2017 preseason. This finding would indicate that the 2017 NCAA ruling was not effective at reducing the head impact burden during the football preseason. Additionally, athletes sustained a significantly higher number of recorded head impacts per week (+ 40%) during the preseason than the regular season, implicating the preseason as a time of elevated repetitive head impact burden. With increased recognition of a possible association between repetitive head impact exposure and concussion, increased preseason exposure may predispose certain athletes to a higher risk of concussion during the preseason and regular season. Accordingly, efforts at reducing concussion incidence in contact sports should include a reduction in overall head impact exposure.
Mental health risk factors and parole decisions: Does inmate mental health status affect who gets released
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: prison release
parole decision making
mental health
United States

description: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Parole decision—the decision to release an incarcerated individual from prison conditionally—is one of the most critical decisions across justice systems around the world. The decision carries with it significant consequences: for the freedom of the individual awaiting release (the parolee); for the safety of the community in which they will return; and for the correctional system overall, especially its organizational capacity. The current study attempts to add to the parole decision-making literature by specifically analyzing the role that mental health factors may play in explaining parole decisions. Research to date is inconclusive on whether or not mental illness is a risk factor for criminal behavior; despite this, individuals with mental health problems generally fare worse on risk assessment tools employed in justice decisions. The study relies on a 1000+ representative sample of parole-eligible individuals in Pennsylvania, United States. To increase reliability, the analyses test for several mental health factors based on information from different sources (i.e., self-reported mental health history; risk assessment tool employed by the Parole Board; and risk assessment tool employed by the Department of Corrections). To address validity concerns, the study controls for other potential correlates of parole decisions. Although the multivariate models explained a considerable amount of variance in parole decisions, the inclusion of mental health variables added relatively little to model fit. The results provide insights into an understudied area of justice decision making, suggesting that despite the stigmatization of mental illness among criminal justice populations, parole board members in Pennsylvania, United States, appear to follow official guidelines rather than to consider more subjective notions that poor mental health should negate parole release.
Spiritual and relational dimensions of parental grieving
Creators: name: Klaassen, Derrick Wayne
Publisher: name: University of British Columbia
Year: 2010

description: This study explored relational and spiritual dimensions of parental grieving. Five bereaved parental couples participated in three sets of interviews over the course of approximately three months. The guiding research question for this study was, “how do spiritual/religious bereaved parents grieve jointly for their deceased child?” Data was collected using the qualitative action-project method and participants were asked how they grieved together for their deceased child and how their spirituality impacted their joint grieving. Joint grieving processes were identified and monitored over approximately three months. The data analysis was informed by the qualitative action project and an instrumental case study method. Joint grieving was described and enacted as goal-directed activities, including both planned and unplanned grieving actions and intended towards the development of an ongoing, relational representation of the deceased child and towards the authentic and vibrant relationships with the partner and the Divine. Joint grieving was facilitated through engaging in joint grieving rituals, sharing individual grieving actions with one’s partner, and accepting the individual grieving style of the partner. Joint grieving was impeded by experiences of disconnection from the significant others, and by various life extraneous stressors. The joint grieving projects were irreducibly related to the spiritual lives of bereaved parents. Their faiths shaped the continuing bonds with their deceased children, offered comfort and spiritual meaning in the midst of suffering and provided an avenue to express disappointment and anger over their loss. The findings offer theoretical, empirical and clinical import for the multi-disciplinary study of parental bereavement.
Association between circulating tumor cells and peripheral blood monocytes in metastatic breast cancer
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: CTC
breast cancer
circulating tumor cells
inflammation
monocytes
prognosis

description: © The Author(s), 2019. Background: We retrospectively evaluated the correlation between a baseline measurement of circulating tumor cells (CTCs) and inflammation-based scores in patients with metastatic breast cancer (MBC). Methods: The optimal value of inflammation-based scores as the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) to predict survival was determined and compared with CTC <5 or ⩾5 per 7.5 ml of blood. Results: In the overall population of 516 women with MBC, CTCs correlated with peripheral blood monocytes (p = 0.008) and neutrophils (p = 0.038). In triple-negative tumors, CTCs correlated with monocyte count (p = 0.009); in HER2+ tumors, CTCs correlated with neutrophil count (p = 0.009), with a trend versus monocyte count (p = 0.061), whereas no correlation was found in HER2– estrogen receptor-positive (ER+) tumors. In multivariate analysis only monocytes were associated with ⩾5 CTCs (OR = 2.72, 95% CI 1.09–6.80, p = 0.033). In multivariable analysis for predictors of overall survival, CTC (⩾5 versus <5), number of metastatic sites (>1 versus 1), tumor subtypes (triple-negative versus HER2– ER+ tumors) and MLR only remained significant. Conclusions: CTC and MLR are predictors of overall survival in MBC. CTC correlates with monocytes, in particular in triple-negative tumors.
Point-like sources among z>11 galaxy candidates: contaminants due to supernovae at high redshifts?
Creators: name: Yan, Haojing
name: Wang, Lifan
name: Ma, Zhiyuan
name: Hu, Lei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The recent searches for z>11 galaxies using the James Webb Space Telescope have resulted in an unexpectedly high number of candidate objects, which imply at least an order of magnitude higher number density of z>11 galaxies than the previously favored predictions. A question has risen whether there are some new types of contaminants among these candidates. The candidate sample of Yan et al. (2023a), totalling 87 dropouts, is the largest one, and we notice that a number of these candidates are point-like. We hypothesize that the point-source dropouts could be supernovae at high redshifts. Further investigation shows that most of their spectral energy distributions indeed can be explained by supernovae at various redshifts from z ~ 1--15, which lends support to this hypothesis. Attributing such point-source dropouts to supernova contamination cannot eliminate the tension, however, because they only account for ~10% of the Yan et al.'s sample. On the other hand, the discovery of "contaminant" supernovae at z>3 will have a series of important implications. Ironically, the existence of supernovae at $z>10$ would still imply that the previously favored picture of early galaxy formation severely underestimates the global star formation rate density such redshifts. Multiple-epoch JWST imaging will be the simplest and yet the most efficient way to further test this hypothesis.
description: ApJ Letters accepted
Proton and neutron electromagnetic form factors from lattice QCD
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: hep-lat
nucl-ex
nucl-th

description: © 2019 authors. Published by the American Physical Society. The electromagnetic form factors of the proton and the neutron are computed within lattice QCD using simulations with quark masses fixed to their physical values. Both connected and disconnected contributions are computed. We analyze two new ensembles of Nf=2 and Nf=2+1+1 twisted mass clover-improved fermions and determine the proton and neutron form factors, the electric and magnetic radii, and the magnetic moments. We use several values of the sink-source time separation in the range of 1.0 to 1.6 fm to ensure ground state identification. Disconnected contributions are calculated to an unprecedented accuracy at the physical point. Although they constitute a small correction, they are non-negligible and contribute up to 15% for the case of the neutron electric charge radius.
Particle motions around regular black holes
Creators: name: Isomura, Kenshin
name: Suzuki, Ryotaku
name: Tomizawa, Shinya
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the bound orbits of massive/massless, neutral particles and photons moving around regular black holes of Fan and Wang. For massive particles, we show the existence of stable/unstable circular orbits and the charge dependence of the radius of the innermost stable circular orbit. Remarkably, we find an unstable circular orbit of photons inside the event horizon. For massless particles and photons, we show that both stable and unstable circular orbits can exist in a regular and horizonless spacetime with a slight overcharge. Then, we also discuss the periapsis shift of massive neutral particles orbiting around the black hole, and show that the charge gives a negative correction to the shift for black holes with small nonlinearity of electrodynamics.
description: 19 pages, 8 figures; v2: analysis of photon orbits improved, refs added, 21 pages; v3: published version, fixed minor typos, fixed figures, 20 pages
Development Impact of FDI in Hotel: Case Study of Terme Tuhelj in Croatia
Creators: name: Perić, Jože
name: Nikšić Radić, Maja
Publisher: name: Campus di Rimini - Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: FDI; Tourism; Development Impact; Terme Tuhelj

description: The main objective of this study is to assess the development impact of foreign direct investment (FDI) in tourism in the case of foreign-owned hotel on the micro-location of Croatia. As an example of this study, the FDI in the Terme Tuhelj, a hotel complex which is located in the area of small local government in the continental Croatia, is choosen. The research methodology is based on questionnaires, unstructured interviews and processing of secondary data sources. The research results show that Terme Tuhelj became the engine of growth of Tuhelj municipality and Krapina-Zagorje County. The Terme Tuhelj example showed how a foreign-owned hotel, in less developed country, has a significant development impact on the local economy.
description: Almatourism - Journal of Tourism, Culture and Territorial Development, Vol 7, No 13 (2016)
One-year postpartum anthropometric outcomes in mothers and children in the LIFE-Moms lifestyle intervention clinical trials
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: Anthropometry
Body Weight
Child
Female
Gestational Weight Gain
Health Promotion
Humans
Life Style
Overweight
Postpartum Period
Pregnancy
Pregnancy Complications

description: BACKGROUND/OBJECTIVES: Excess gestational weight gain (GWG) is a risk factor for maternal postpartum weight retention and excessive neonatal adiposity, especially in women with overweight or obesity. Whether lifestyle interventions to reduce excess GWG also reduce 12-month maternal postpartum weight retention and infant weight-for-length z score is unknown. Randomized controlled trials from the LIFE-Moms consortium investigated lifestyle interventions that began in pregnancy and tested whether there was benefit through 12 months on maternal postpartum weight retention (i.e., the difference in weight from early pregnancy to 12 months) and infant-weight-for-length z scores. SUBJECTS/METHODS: In LIFE-Moms, women (N = 1150; 14.1 weeks gestation at enrollment) with overweight or obesity were randomized within each of seven trials to lifestyle intervention or standard care. Individual participant data were combined and analyzed using generalized linear mixed models with trial entered as a random effect. The 12-month assessment was completed by 83% (959/1150) of women and 84% (961/1150) of infants. RESULTS: Compared with standard care, lifestyle intervention reduced postpartum weight retention (2.2 ± 7.0 vs. 0.7 ± 6.2 kg, respectively; difference of -1.6 kg (95% CI -2.5, -0.7; p = 0.0003); the intervention effect was mediated by reduction in excess GWG, which explained 22% of the effect on postpartum weight retention. Lifestyle intervention also significantly increased the odds (OR = 1.68 (95% CI, 1.26, 2.24)) and percentage of mothers (48.2% vs. 36.2%) at or below baseline weight at 12 months postpartum (yes/no) compared with standard care. There was no statistically significant treatment group effect on infant anthropometric outcomes at 12 months. CONCLUSIONS: Compared with standard care, lifestyle interventions initiated in pregnancy and focused on healthy eating, increased physical activity, and other behavioral strategies resulted in significantly less weight retention but similar infant anthropometric outcomes at 12 months postpartum in a large, diverse US population of women with overweight and obesity.
Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: Adoptive Transfer
Animals
Anti-HIV Agents
CRISPR-Cas Systems
Combined Modality Therapy
DNA, Viral
Gene Editing
HIV Infections
HIV-1
Humans
Mice
Treatment Outcome
Virus Latency

description: © 2019, The Author(s). Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice. HIV-1 subgenomic DNA fragments, spanning the long terminal repeats and the Gag gene, are excised in vivo, resulting in elimination of integrated proviral DNA; virus is not detected in blood, lymphoid tissue, bone marrow and brain by nested and digital-droplet PCR as well as RNAscope tests. No CRISPR-Cas9 mediated off-target effects are detected. Adoptive transfer of human immunocytes from dual treated, virus-free animals to uninfected humanized mice fails to produce infectious progeny virus. In contrast, HIV-1 is readily detected following sole LASER ART or CRISPR-Cas9 treatment. These data provide proof-of-concept that permanent viral elimination is possible.
Willingness to pay for Ecotourism in Oyan Lake, Nigeria
Creators: name: Moyib, Folake Ramat
name: Ojo, Olugbemiga S
name: Ayodele, Ibukun A.
Publisher: name: Campus di Rimini - Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: Ecotourism; Dichotomous choice; Group tourism; Logistic Regression; Viewing-fees

description: This study examined tourists’ willingness to pay for relaxation and factors that influence the visitors’ willingness to pay for ecotourism at Oyan Lake, Nigeria. A cross sectional survey with the use of questionnaire was done; the dichotomous choice method based on payment card method was employed to elicit some information. Three hundred and twenty tourists above 16years that visited the Lake between 2013 and 2014 were selected as respondents. The logistic regression result revealed that visit to local communities, amount to be paid within group, tourism-awareness, group tourism, and the amount that individual tourist should pay had significant effects on the tourists’ willingness to pay for tourism. The study indicated that while tourists are willing to support Oyan Lake, the introduction of additional viewing fees within groups would be acceptable; government should improve the marketing of this destination through awareness creation.
description: Almatourism - Journal of Tourism, Culture and Territorial Development, Vol 7, No 13 (2016)
Higgs finder and mass estimater
Creators: name: Barger, Vernon
name: Huang, Peisi
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We exploit the spin and kinematic correlations in the decay of a scalar boson into a pair of real or virtual W-bosons, with both W-bosons decaying leptonically, for Higgs boson discovery at 7 TeV LHC energy with 10 fb-1 luminosity. Without reconstruction of the events, we obtain estimators of the higgs mass from the peak and width of the signal distribution in (mll). The separation of signal and background with other distributions, such as the azimuthal angle between two W decay planes, the rapidity difference between the two leptons, missing ET and the pT of leptons, are also prescribed. Our approach identifies the salient higgs to dilepton signatures that allow subtraction of the continuum W*W* background.
description: 7 pages 10 figures, added references
The role of hedonics in the Human Affectome
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: Pleasure
Displeasure
Reward
Pain
Valence
Nucleus accumbens
Ventromedial prefrontal cortex
Orbitofrontal cortex

description: © 2019 The Authors Experiencing pleasure and displeasure is a fundamental part of life. Hedonics guide behavior, affect decision-making, induce learning, and much more. As the positive and negative valence of feelings, hedonics are core processes that accompany emotion, motivation, and bodily states. Here, the affective neuroscience of pleasure and displeasure that has largely focused on the investigation of reward and pain processing, is reviewed. We describe the neurobiological systems of hedonics and factors that modulate hedonic experiences (e.g., cognition, learning, sensory input). Further, we review maladaptive and adaptive pleasure and displeasure functions in mental disorders and well-being, as well as the experience of aesthetics. As a centerpiece of the Human Affectome Project, language used to express pleasure and displeasure was also analyzed, and showed that most of these analyzed words overlap with expressions of emotions, actions, and bodily states. Our review shows that hedonics are typically investigated as processes that accompany other functions, but the mechanisms of hedonics (as core processes)have not been fully elucidated.
Testing $Λ$CDM cosmology in a binned universe: anomalies in the deceleration parameter
Creators: name: Pastén, Erick
name: Cárdenas, Victor
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the reconstructed deceleration parameter splitting the data in different redshift bins, fitting both a cosmographic luminosity distance and also assuming a flat $Λ$CDM model, using the Pantheon+ sample of type Ia supernova data (SNIA). We observe tensions $\sim 2σ-3σ$ for different redshift and distance indicators if the full sample is used. However, those tensions disappear when the SNIA at $z<0.008$ are removed. If the data is splitted in 2 hemispheres according to our movement w.r.t CMB, a strange $3.8 σ$ tension appears in one of the samples between particular redshift bins. Finally, considering posterior distribution as Gaussian, general linear model prefers a positive slope for $q_0$ across redshift bins opposed to a zero slope expected in a $Λ$CDM universe. We discuss possible explanations for our results and the influence of lowest redshift SNIA data in cosmological analysis.
description: Published version in Physics of the Dark Universe journal
title: Das Energiemosaik Austria
title: Eine kommunale Energie- und Treibhausgasdatenbank für Österreich
titleType: Subtitle
Creators: name: Abart-Heriszt, Lore
Publisher: name: Zenodo
Year: 2023

description: Angesichts des sich abzeichnenden Klimawandels sollen auf allen räumlichen Ebenen Beiträge zur Energiewende und zum Klimaschutz geleistet werden. Für die Entwicklung dieser Strategien, die vornehmlich auf eine Verringerung des Energieverbrauchs und der Treibhausgasemissionen abzielen, sind Kenntnisse hinsichtlich der Ausgangslage unerlässlich. Auf kommunaler Ebene stehen jedoch weder statistische Daten zum Energieverbrauch zur Verfügung noch liegen Angaben zu den Treibhausgasemissionen vor. Um diese Lücke zu schließen, wurde eine Methode zur Modellierung des Energieverbrauchs und der Treibhausgasemissionen auf Gemeindeebene entwickelt und österreichweit umgesetzt: Mit dem Energiemosaik Austria steht allen österreichischen Städten und Gemeinden eine energie- und klimarelevante Orientierungshilfe und dadurch eine Referenz für die Formulierung künftiger Strategien zur Energiewende und zum Klimaschutz zur Verfügung.
The oncolytic virus dl922-947 triggers immunogenic cell death in mesothelioma and reduces Xenograft growth
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: virotherapy
oncolytic virus
dl922-947
mesothelioma
immunogenic cell death

description: © 2019 Di Somma, Iannuzzi, Passaro, Forte, Iannone, Gigantino, Indovina, Botti, Giordano, Formisano, Portella, Malfitano and Pentimalli. Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure that urgently requires effective therapeutic strategies. Current treatments are unable to increase significantly patient survival, which is often limited to <1 year from diagnosis. Virotherapy, based on the use of oncolytic viruses that exert anti-cancer effects by direct cell lysis and through the induction of anti-tumor immune response, represents an alternative therapeutic option for rare tumors with limited life expectancy. In this study, we propose the use of the adenovirus dl922-947, engineered to allow selective replication in cancer cells, to counteract MPM. Methods: We performed a thorough preclinical assessment of dl922-947 effects in a set of MPM cell lines and xenografts. Cytotoxicity of dl922-947 alone and in combination assays was evaluated by sulforhodamine B assay. Cell cycle, calreticulin expression, and high mobility group box protein 1 (HMGB1) secretion were determined by flow cytometry, whereas ATP content was determined by a luminescence-based bioassay. The modulation of angiogenic factors in MPM-infected cells was evaluated through ELISA. Results: We found that dl922-947 infection exhibits cytotoxic effects in MPM cell lines, affecting cell viability, cell cycle progression, and regulating main hallmarks of immunogenic cell death inducing calreticulin surface exposure, HMGB1 and ATP release. Our results also suggest that dl922-947 may affect angiogenic signals by regulation of VEGF-A and IL-8 secretion. Furthermore, dl922-947 shows anti-tumor efficacy in murine xenograft models reducing tumor growth and enhancing survival. Finally, the combination with cisplatin potentiated the cytotoxic effect of dl922-947. Conclusions: Overall our data identify virotherapy, based on the use of dl922-947, as a new possible therapeutic strategy against MPM, which could be used alone, in combination with standard chemotherapy drugs, as shown here, or other approaches also aimed at enhancing the antitumoral immune response elicited by the virus.
Principles for single-pixel terahertz imaging based on the engineering of illuminating and collecting nonparaxial diffractive optics
Creators: name: Orlov, Sergej
name: Ivaškevičiūtė-Povilauskienė, Rusnė
name: Mundrys, Karolis
name: Kizevičius, Paulius
name: Nacius, Ernestas
name: Jokubauskis, Domas
name: Ikamas, Kęstutis
name: Lisauskas, Alvydas
name: Minkevičius, Linas
name: Valušis, Gintaras
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: The art of light engineering unveils a world of possibilities through the meticulous manipulation of photonic properties such as intensity, phase, and polarization. The precise control over these optical properties under various conditions finds application in fields spanning communication, light-matter interactions, laser direct writing, and imaging, enriching our technological landscape. In this study, we embark on a journey to establish a rational framework for the design and assembly of nonparaxial THz imaging systems. Our focus centers on a lensless photonic system composed solely of flat-silicon diffractive optics. These elements include the high-resistivity silicon-based nonparaxial Fresnel zone plate, the Fibonacci lens, the Bessel axicon, and the Airy zone plate, all meticulously crafted using laser ablation technology. A systematic exploration of these flat elements in various combinations sheds light on their strengths and weaknesses. Our endeavor extends to the practical application of these optical components, where they illuminate samples and capture the light scattered from these raster-scanned samples using single-pixel detectors. Through a comprehensive examination, we evaluate imaging systems across diverse metrics that include contrast, resolution, depth of field and focus. This multifaceted approach allows us to distill rational design principles for the optimal assembly of THz imaging setups. The findings of this research chart an exciting course toward the development of compact, user-friendly THz imaging systems where sensors and passive optical elements seamlessly integrate into a single chip. These innovations not only enhance capabilities in THz imaging but also pave the way for novel applications, ushering in a new encouraging era of advanced THz photonic technology.
description: 26 pages
Evaluating the Competitiveness of the Northern and Southern Macro-Regions of Italy
Creators: name: Aquilino, Lucia
name: Wise, Nicholas
Publisher: name: Campus di Rimini - Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: Competitiveness; Mature Tourism Regions; Italy

description: This study uses the Crouch and Ritchie (1999) model of competitiveness to investigate/measure the competitiveness of northern and southern Italian macro-regions. Researching competitive advantages along with identifying strengths/weaknesses represent the objectives of this study. 156 responses were analysed, and findings show that northern regions tend to be more competitive than southern regions. While naturally endowed and created resources represent strengths in both regions, the competitiveness of all the determinant factors included in the tourism development, planning and policy of both tourist destinations are found to be quite inadequate. Moreover, the findings revealed that these mature destinations are experiencing the effects unleashed by a number of trends such as the development of new forms of tourism, the increasing number of tourist arrivals, the growth of the global economy and the sophistication of tourists’ tastes, representing both opportunities and threats that Italian destinations need to consider when planning/developing new strategies.
description: Almatourism - Journal of Tourism, Culture and Territorial Development, Vol 7, No 13 (2016)
Single dish performance of KVN 21-m radio telescopes:Simultaneous observations at 22 and 43 GHz
Creators: name: Lee, Sang-Sung
name: Byun, Do-Young
name: Oh, Chung Sik
name: Han, Seog-Tae
name: Je, Do-Heung
name: Kim, Kee-Tae
name: Wi, Seog-Oh
name: Cho, Se-Hyung
name: Sohn, Bong Won
name: Kim, Jaeheon
name: Lee, Jeewon
name: Oh, Se-Jin
name: Song, Min-Gyu
name: Kang, Jiman
name: Jung, Moon-Hee
name: Lee, Jeong Ae
name: Oh, Junghwan
name: Bae, Jae-Han
name: Yun, So-Young
name: Lee, Jung-Won
name: Kim, Bong Gyu
name: Chung, Hyunsoo
name: Roh, Duk-Gyoo
name: Lee, Chang Hoon
name: Kim, Hyun Goo
name: Kim, Hyo Ryoung
name: Yeom, Jae-Hwan
name: Kurayama, Tomoharu
name: Jung, Taehyun
name: Park, Pulun
name: Kim, Min Joong
name: Yoon, Dong-Hwan
name: Kim, Won-Ju
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We report simultaneous multi-frequency observing performance at 22 and 43 GHz of the 21-m shaped-Cassegrain radio telescopes of the Korean VLBI Network (KVN). KVN is the first millimeter-dedicated VLBI network in Korea having a maximum baseline length of 480 km. It currently operates at 22 and 43 GHz and planed to operate in four frequency bands, 22, 43, 86, and 129 GHz. The unique quasioptics of KVN enable simultaneous multi-frequency observations based on efficient beam filtering and accuarate antenna-beam alignment at 22 and 43 GHz. We found that the offset of the beams is within <5 arcseconds over all pointing directions of antenna. The dual polarization, cooled HEMT receivers at 22 and 43 GHz result in receiver noise temperatures less than 40 K at 21.25-23.25 GHz and 80 K at 42.11-44.11 GHz. The pointing accuracies have been measured to be 3 arcseconds in azimuth and elevation for all antennas. The measured aperture efficiencies are 65%(K)/67%(Q), 62%(K)/59%(Q), and 66%(K)/60%(Q) for the three KVN antennas, KVNYS, KVNUS, and KVNTN, respectively. The main-beam efficiencies are measured to be 50%(K)/52%(Q), 48%(K)/50%(Q), and 50%(K)/47%(Q) for KVNYS, KVNUS, and KVNTN, respectively. The estimated Moon efficiencies are 77%(K)/90%(Q), 74%(K)/79%(Q), and 80%(K)/86%(Q) for KVNYS, KVNUS, KVNTN, respectively. The elevation dependence of the aperture efficiencies is quite flat for elevations > 20 degrees.
description: 33 pages, 10 figures, 9 tables, Accepted for publication in PASP
Barriers to collaboration among tourism industry stakeholders. Case study: Mashhad Metropolis
Creators: name: Azizpour, Farhad
name: Fathizadeh, Farah
Publisher: name: Campus di Rimini - Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: tourist destination management; organizational collaboration; case study; Mashhad

description: In a tourist destination there are usually various stakeholders with different goals. Achieving cooperation and integration among them is a major concern for policy makers and urban managers. In this regard, the role of tourist destination management becomes important more than ever. Therefore, cooperation between organizations can be an effective model but very little researches have been done about this topic. To fill the gap, this study tends to analyze the collaboration between tourism-related public and private institutions in the city of Mashhad.

This study applies qualitative case study methodology approach. Data are collected using semi-structured interview. The results showed that the main factors affecting the non-collaboration between related-tourism organizations in Mashhad city include: lack of a systematic approach, weak legal structure, poor planning, lack of integrated tourism management, and the weakness of the policy-making system.
description: Almatourism - Journal of Tourism, Culture and Territorial Development, Vol 7, No 13 (2016)
Track-Based Alignment of the Inner Detector of ATLAS
Creators: name: Ovcharova, Ana
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: ATLAS is a multipurpose experiment at the LHC. The tracking system of ATLAS, embedded in a 2 T solenoidal field, is composed of different technologies: silicon planar sensors (pixel and microstrips) and drift-tubes. The procedure used to align the ATLAS tracker and the results of the alignment using data recorded during 2010 and 2011 using LHC proton-proton collision runs at 7 TeV are presented. Validation of the alignment is performed by measuring the alignment observables as well as many other physics observables, notably resonance invariant masses in a wide mass range. The E/p distributions for electrons from Z and W are also extensively used. The results indicate that, after the alignment with real data, the attained precision of the alignment constants is approximately 5 μm. The systematic errors due to the alignment that may affect physics results are under study.
description: Presented at the 2011 Hadron Collider Physics symposium (HCP-2011), Paris, France, November 14-18 2011, 3 pages, 7 figures
Deformations of an active liquid droplet
Creators: name: Kree, Reiner
name: Zippelius, Annette
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: A fluid droplet in general deforms, if subject to active driving, such as a finite slip velocity or active tractions on its interface. We show that these deformations and their dynamics can be computed analytically in a perturbation theory in the inverse surface tension using an approach based on vector spherical harmonics. In lowest order, the deformation is of first order, yet it affects the flow fields inside and outside of the droplet in zeroth order. Hence a correct description of the flow has to allow for shape fluctuations, even in the limit of large surface tension.
Sense of Place in Tourism and Leisure: the Case of Touring Skiers in Quebec
Creators: name: Roult, Romain
name: Adjizian, Jean-Marc
name: Auger, Denis
Publisher: name: Campus di Rimini - Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: Leisure; Tourism; Sense of place; Ski touring; Quebec

description: The concept of sense of place has become central in understanding various modern phenomena in leisure. Tourism promoters in outdoor recreation now emphasize opportunities to bond with nature, with ‘wild’ landscapes or with the authentic value of a destination. However, studying this tourism and recreation issue from the standpoint of ‘place’, which draws upon notions of attendance, identification and social and individual meaning, is lacking in modern studies. This paper, based on a quantitative approach using a questionnaire survey administered to touring skiers in Quebec (n=829), thus aims to present the links between various practice settings and the perceived meaning and identification that skiers attach to their practice sites.
description: Almatourism - Journal of Tourism, Culture and Territorial Development, Vol 7, No 13 (2016)
New Horizons in Gravity: Dark Energy and Condensate Stars
Creators: name: Mottola, Emil
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Black holes are an apparently unavoidable prediction of classical General Relativity, at least if matter obeys the strong energy condition rho + 3p > 0. However quantum vacuum fluctuations generally violate this condition, as does the eq. of state of cosmological dark energy. When quantum effects are considered, black holes lead to a number of thermodynamic paradoxes associated with the Hawking temperature and assumption of black hole entropy, which are briefly reviewed. It is argued that the largest quantum effects arise from the conformal scalar degrees of freedom generated by the trace anomaly of the stress-energy tensor in curved space. At event horizons these can have macroscopically large backreaction effects on the geometry, potentially removing the classical event horizon of black hole and cosmological spacetimes, replacing them with a quantum phase boundary layer, where the effective value of the gravitational vacuum energy density can change. In the effective theory including the quantum effects of the anomaly, the cosmological term becomes a dynamical condensate, whose value depends upon boundary conditions at the horizon. By taking a positive value in the interior of a fully collapsed star, the effective cosmological term removes any singularity, replacing it with a smooth dark energy de Sitter interior. The resulting gravitational vacuum condensate star (or gravastar) configuration resolves all black hole paradoxes, and provides a testable alternative to black holes as the final quantum mechanical end state of complete gravitational collapse. The observed dark energy of our universe likewise may be a macroscopic finite size effect whose value depends not on Planck scale or other microphysics but on the cosmological Hubble horizon scale itself.
description: Plenary Talk given at the Spanish Relativity Meeting ERE2010, 6-10 Sept., 2010 in Granada, Spain. To be published in the Journal of Physics: Conference Series
Electrospun bimetallic NiCr nanoparticles@carbon nanofibers as an efficient catalyst for hydrogen generation from ammonia borane
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: nanofibers
hydrogen production
energy application
electrospinning

description: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. In this study, we report on the fabrication and utilization of NiCr alloy nanoparticles (NPs)-decorated carbon nanofibers (CNFs) as efficient and competent non-precious catalysts for the hydrolytic dehydrogenation of ammonia borane (AB) at 25 ± 2◦ C. The introduced NFs have been fabricated in one step using a high-temperature thermal decomposition of the prepared electrospun nanofiber mats (nickel acetate tetrahydrate, chromium acetate dimer, and polyvinyl alcohol) in an inert atmosphere. The chemical composition of the NFs with different proportions of Ni1−x Crx (x = 0.0, 0.1, 0.15, 0.2, 0.25, 0.3) was established via standard characterization techniques. These techniques proved the formation of disorder Cr2 Ni3 alloy and carbon for all the formulations. The as-synthesized composite NFs exhibited a higher catalytic performance for AB dehydrogenation than that of Cr-free Ni–CNFs. Among all the formulations, the sample composed of 15% Cr shows the best catalytic performance, as more H2 was released in less time. Furthermore, it shows good stability, as it is recyclable with little decline in the catalytic activity after six cycles. It also demonstrates the activation energy, entropy (∆S), and enthalpy (∆H) with 37.6 kJ/mole, 0.094 kJ/mole, and 35.03 kJ/mole, respectively. Accordingly, the introduced catalyst has a lower price with higher performance encouraging a practical sustainable H2 energy application from the chemical hydrogen storage materials.