title: ÐÐ¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐµ Ð¼Ð¸ÐºÑÐ¾ÑÑÐµÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ ÑÐ¸ÑÐ¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°: Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ»ÐµÐºÑÑÐ¾Ð¿Ð¾Ð²ÐµÑÑ Ð½Ð¾ÑÑÐ½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¸ ÑÐ¾ÑÐ±ÑÐ¸Ñ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Polymer microspheres as carriers of a cytostatic drug: study of electro-surface properties and sorption of doxorubicin
Creators: name: Ð¤Ð°ÑÐµÐµÐ²Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð¿Ð¾Ð»Ð¸ÑÐ»ÐµÐºÑÑÐ¾Ð»Ð¸ÑÐ½ÑÐµ Ð¼Ð¸ÐºÑÐ¾ÑÑÐµÑÑ
Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½
Ñ Ð¸Ð¼Ð¸Ð¾ÑÐ¼Ð±Ð¾Ð»Ð¸Ð·Ð°ÑÐ¸Ñ
ÐºÐ¾Ð½Ð´ÑÐºÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¸ÑÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¸ÑÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÑÐ¿ÐµÐºÑÑÐ¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
polyelectrolyte microspheres
doxorubicin
chemoembolization
conductometric titration
potentiometric titration
spectrophotometry

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description: The subject of the graduate qualification work is Â«Polymer microspheres as carriers of a cytostatic drug: study of electrical properties and sorption of doxorubicinÂ». The given work is devoted to studying polyelectrolyte microspheres, and to investigation of their electrical and sorption properties. The research set the following goals: 1. Synthesis of polyelectrolyte microspheres; 2. Studying of the morphological and electrical properties of the obtained microspheres; 3. Investigation of the sorption properties of microspheres using the drug doxorubicin by spectrophotometry. The work was fulfilled on the premises of the laboratory of polymer sorbents and carriers for biotechnologies of the IMC RAS, which included collection of factual materials. As a result, polyelectrolyte microspheres were synthesized; their diameter in an aqueous solution is about 300 Î¼m, and after drying, it is 100 Î¼m. Also, their morphological and electrical properties have been studied. The concentration of functional groups on the surface of the microspheres was 1.17Â·10-4 g-eq. The concentration of sulfonic groups on the surface and in the volume was 2.7Â·10-4 g-eq. It was shown that in aqueous solutions with given pH values, the dynamic viscosity increases. The sorption properties of polyelectrolyte microspheres: the largest amount of doxorubicin per 1 mg of microspheres is sorbed at pH = 6 - 35.9Î¼g/mg. Desorption of doxorubicin occurs more efficiently at pH = 2 and 89% of doxorubicin is desorbed from microspheres in 21 days.