cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of an optimized liposomal formulation of a camptothecin to improve treatment of neuroblastoma
Creators: name: Chernov, Alina
Publisher: name: University of British Columbia
Year: 2016

description: Purpose: To develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Experimental design: Cytotoxic activity of both camptothecins (topotecan (Hycamtin) and irinotecan (Camptosar)) was determined against SK-N-SH; IMR-32 and LAN-1 neuroblastoma cell lines. Sphingomyelin (SM)/Cholesterol (Chol) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)/Chol liposomes were prepared using extrusion methods and then loaded with topotecan using a method that relies on copper-drug complexation in combination with a transmembrane pH gradient. The influence of lipid composition and encapsulated drug-to-lipid ratio was assessed in-vitro in the presence and absence of serum. Dose-range finding studies were used to define maximum tolerated dose of the optimized liposomal formulation. Pharmacokinetic studies were completed to compare plasma elimination of topotecan following intravenous administration of the liposomal formulation or the currently used clinical product (Hycamtin). Studies were done in NRG mice bearing established subcutaneous tumours. The anti-tumour activity of the liposomal formulation was compared to Hycamtin when administered to NRG mice with established neuroblastoma tumours. Results: Topotecan was significantly more effective than irinotecan when used to treat neuroblastoma cell lines (as determined by IC50). Increased exposure time to topotecan further increased the drug potency against all neuroblastoma cell lines. In vitro studies showed that SM/Chol liposomes retained topotecan better than DSPC/Chol liposomes. Decreasing the drug-to-lipid ratio from 0.1 to 0.025(mol: mol) engendered significant increase in drug retention. The optimized SM/Chol liposomal topotecan formulation exhibited a 10-fold increase in plasma half-life and a 1000-fold increase in AUC0-24h when compared to Hycamtin administered at equivalent doses. When administered at 5mg/kg, SM/Chol liposomal topotecan was significantly more effective than Hycamtin administered at 2-times the dose. The liposomal formulation increased the life span of mice by 50% for the systemic tumour model and by 87% for the subcutaneous models. Conclusion: Increased systemic drug exposure following administration of the optimized SM/Chol liposomal topotecan formulation produced superior response in subcutaneous and systemic models of neuroblastoma. In the future, this formulation will be assessed in combination with radiotherapy and immunotherapy treatment modalities currently used in neuroblastoma therapy.
Computational modeling of electroactive hydrogels for cartilage-tissue repair using electrical stimulation
Creators: name: Farooqi, Abdul Razzaq
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 620 Engineering & allied operations
subject: 621.3 Electrical Engineering, Electronics

description: The self-repair capability of articular cartilage is limited due to the lack of vascularization and low turnover of its extracellular matrix. In quest of therapeutic options, electrical stimulation has been proposed for improving tissue engineering approaches for the repair of articular cartilage. The use of electrical stimulation for the repair of cartilage tissue requires detailed preliminary analysis. In this thesis, computational models have been studied that can be used for optimizing the experimental protocols for cartilage–tissue repair using electrical stimulation.
Additional file 1 of Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage
Creators: name: Dou, Yunxiao
name: Xie, Junchao
name: Tan, Yan
name: Zhang, Min
name: Zhao, Yanxin
name: Liu, Xueyuan
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Mental Health

description: Additional file 1: Fig. S1. sEVs-depleted medium had no effect on the cell viability of Aβ-treated neurons. (A) Image of cultured primary cortical neurons on DIV 15. (B) Immunostaining of cortical cultures on DIV 15 for the detection of GFAP+ glial cells (red) vs. NeuN+ neurons (green). (C) The morphology of sEVs from glutamate or GABA-treated neurons was observed under a transmission electron microscope. Glutamate sEVs = sEVs derived from 10 μM glutamate-treated neurons, GABA sEVs = sEVs derived from 300 μM GABA-treated neurons. (D-F) Neurons were incubated with PBS (the same amount as the solvent of the sEVs), sEVs and sEV-depleted medium (Negative control, NC), then with Aβ as before. Neuronal viability in Ctrl-sEV-treated group (D), glutamate-sEV-treated group (E), GABA-sEV-treated group (F) and NC group were compared using CCK-8. n = 3. Data are presented as the mean ± SEM, ***p < 0.001, ****p < 0.0001.
Notioxenus Wollaston 1861
Creators: name: Zimmerman, Elwood C.
Publisher: name: Zenodo
Year: 1942
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Anthribidae
Notioxenus

description: Genus NOTIOXENUS Wollaston, 1861 This genus has a discontinuous, predominantly tropicopolitan distribution. Only one species, the southeastern Polynesian Notioxenus cylindricus Jordan (1933), is known from the entire Pacific region east of Guam. Two species have been described from Japan, and it is probable that many undescribed species are to be found in the regions to the south and west of Guam.
description: Published as part of Zimmerman, Elwood C., 1942, Anthribidae Of Guam, pp. 65-72 in Insects of Guam I, Honolulu, Hawaii :Bernice P. Bishop Museum on page 68, DOI: 10.5281/zenodo.5159835
Properties of the Resonance Lambda(1520) as seen in the Forward Electroproduction at JLab Hall A
Creators: name: Strakovsky, I. I.
name: Qiang, Y.
name: Azimov, Ya. I.
name: Briscoe, W. J.
name: Gao, H.
name: Higinbotham, D. W.
name: Nelyubin, V. V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: High-resolution spectrometer measurements of the reaction H(e,e' K+)X at small Q2 are used to extract the mass and width of the Lambda(1520). We investigate dependence of the resonance parameters on different parametrizations of the background and the resonance peak itself. Our final values for the Breit-Wigner parameters are M=1520.4+-0.6(stat)+-1.5(syst) MeV and Gamma=18.6+-1.9(stat)+-1(syst) MeV. The width appears to be more sensitive to the assumptions than the mass. We also estimate, for the first time, the pole position for this resonance and find that both the pole mass and width seem to be smaller than their Breit-Wigner values.
description: 4 pages, 1 figure, to appear in the proceedings of MENU 2010
Wissensbasierte Ausbildung von Architekten
Creators: name: Koch, Volker
Publisher: name: Karlsruhe
Year: 2008

description: Die kritische Betrachtung der beruflichen Situation von Architekten zeigt, dass die Krise des Berufs strukturelle Ursachen aufweist und das Tätigkeitsumfeld der Architekten dauerhaft verändern werden. Die Arbeit untersucht die spezifischen Anforderungen an Architekten, bewertet die zur Verfügung stehenden informationstechnischen Werkzeuge und stellt geeignete didaktische Methoden vor, um die Ausbildung von Studierenden in einem zukünftigen und erweiterten Berufsumfeld zu ermöglichen.
Additional file 6: of Long-term health and germline transmission in transgenic cattle following transposon-mediated gene transfer
Creators: name: Yum, Soo-Young
name: Lee, Song-Jeon
name: Park, Sin-Gi
name: Shin, In-Gang
name: Hahn, Sang-Eun
name: Choi, Woo-Jae
name: Kim, Hee-Soo
name: Kim, Hyeong-Jong
name: Bae, Seong-Hun
name: Lee, Je-Hyeong
name: Moon, Joo-Yeong
name: Lee, Woo-Sung
name: Lee, Ji-Hyun
name: Lee, Choong-Il
name: Kim, Seong-Jin
name: Jang, Goo
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Table S1. All transgene integration sites in SNU-F1â 2. (DOCX 24 kb)
On the Question of Coincidence Between Energy Gaps and Kohn Anomalies
Creators: name: Johnston, S.
name: Sorini, A. P.
name: Moritz, B.
name: Devereaux, T. P.
name: Scalapino, D. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Recently, neutron scattering spin echo measurements have provided high resolution data on the temperature dependence of the linewidth $Γ({\bf q},T)$ of acoustic phonons in conventional superconductors Pb and Nb. [P. Aynajian, et al, Science 319, 1509 (2008)]. At low temperatures the merging of the $2Δ(T)$ structure in the linewidth with a peak associated with a low lying $\hbarω_{\bf q_{KA}}$ Kohn anomaly suggested a coincidence between $2Δ(0)$ and $\hbarω_{\bf q_{KA}}$ in Pb and Nb. Here we carry out a standard BCS calculation of the phonon linewidth to examine its temperature evolution and explore how close $2Δ(0)/\hbarω_{\bf q_{KA}}$ must be to unity in order to be consistent with the neutron data.
description: 6 pages, 5 figures
title: Fog Computing-Framework für ressourcenbeschränkte Systeme
Creators: name: Schwendinger, Martin
Publisher: name: FH Vorarlberg
Year: 2020
Subjects: subject: 004 Informatik

description: Die cloud-basierte Verarbeitung von Datenströmen von IoT-Geräten ist aufgrund hoher Latenzzeiten für zeitkritische Anwendungen nur beschränkt möglich. Fog Computing soll durch Nutzung der Rechen- und Speicherkapazitäten von lokal vorhandenen Geräten eine zeitnahe Datenverarbeitung und somit eine Verringerung der Latenzzeit ermöglichen. In dieser Arbeit werden Anforderungen an ein Fog Computing-Framework erhoben, das die dynamische Zuweisung und Ausführung von Services auf ressourcen-beschränkten Geräten in einem lokalen Netzwerk zur dezentralen Datenverarbeitung ermöglicht. Zudem wird dieses Framework prototypisch für mehrere Transportkanäle, unterschiedliche Betriebssysteme und Plattformen realisiert. Dazu werden die Möglichkeiten der Skriptsprache Lua und des Kommunikationsmechanismus Remote Procedure Call genutzt. Das Resultat ist ein positiver Machbarkeitsnachweis für Fog Computing-Funktionalitäten auf ressourcenbeschränkten Systemen. Zudem werden eine geringere Latenz und eine Reduktion der Netzwerklast ermöglicht.
description: Cloud-based processing of data streams from IoT devices is due to high latency limited for time-critical applications. Fog computing is intended to enable timely processing and thus optimize latency by utilizing the computing and storage capacities of locally available devices. In this thesis requirements for a fog computing framework are defined, which allows the dynamic allocation and execution of services on resource limited devices in a local network for decentralized data processing. In addition, this framework is prototypically realized for multiple transport channels, different operating systems and platforms. For this purpose, the possibilities of the scripting language Lua and remote procedure call as a communication mechanism are used. The result is a positive proof of concept for fog computing functionalities on resource-constrained systems. In addition, it enables a lower latency and a reduction of the network load.
Methods of optimizing X-ray optical prescriptions for wide-field applications
Creators: name: Elsner, Ronald F.
name: O'Dell, Stephen L.
name: Ramsey, Brian D.
name: Weisskopf, Martin C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We are working on the development of a method for optimizing wide-field X-ray telescope mirror prescriptions, including polynomial coefficients, mirror shell relative displacements, and (assuming 4 focal plane detectors) detector placement along the optical axis and detector tilt. With our methods, we hope to reduce number of Monte-Carlo ray traces required to search the multi-dimensional design parameter space, and to lessen the complexity of finding the optimum design parameters in that space. Regarding higher order polynomial terms as small perturbations of an underlying Wolter I optic design, we begin by using the results of Monte-Carlo ray traces to devise trial analytic functions, for an individual Wolter I mirror shell, that can be used to represent the spatial resolution on an arbitrary focal surface. We then introduce a notation and tools for Monte-Carlo ray tracing of a polynomial mirror shell prescription which permits the polynomial coefficients to remain symbolic. In principle, given a set of parameters defining the underlying Wolter I optics, a single set of Monte-Carlo ray traces are then sufficient to determine the polymonial coefficients through the solution of a large set of linear equations in the symbolic coefficients. We describe the present status of this development effort.
description: 14 pages, to be presented at SPIE conference 7732 (paper 93)
Mauia Blackburn 1885
Creators: name: Zimmerman, Elwood C.
Publisher: name: Zenodo
Year: 1942
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Anthribidae
Mauia

description: Genus MAUIA Blackburn, 1885 This genus contains three species. In addition to the widespread genotype listed herein, one species has been described from Papua and one from the Malay Peninsula.
description: Published as part of Zimmerman, Elwood C., 1942, Anthribidae Of Guam, pp. 65-72 in Insects of Guam I, Honolulu, Hawaii :Bernice P. Bishop Museum on page 70, DOI: 10.5281/zenodo.5159835
Stars and ionized gas in S0 galaxy NGC 7743: an inclined large-scale gaseous disk
Creators: name: Katkov, Ivan Yu.
name: Moiseev, Alexei V.
name: Sil'chenko, Olga K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We used deep long-slit spectra and integral-field spectral data to study the stars and ionized gas kinematics and stellar population properties in the lenticular barred galaxy NGC 7743. We have shown that ionized gas at the distances larger than 1.5 kpc from the nucleus settles in the disk which is significantly inclined to the stellar disk of the galaxy. Making different assumptions about the geometry of the disks and involving different sets of emission lines into the fitting, under the assumption of thin flat disk circular rotation, we obtain the full possible range of angle between the disks to be 34+/-9 or 77+/-9 deg. The most probable origin of the inclined disk is the external gas accretion from a satellite, orbiting the host galaxy with a corresponding angular momentum direction. The published data on the HI distribution around NGC 7743 suggest that the galaxy has a gas-rich environment. The emission-line ratio diagrams imply the domination of shock waves in the ionization state of the gaseous disk, whereas the contribution of photoionization by recent star formation seems to be negligible. In some parts of the disk a difference between the velocities of the gas emitting in the forbidden lines and in the Balmer lines is detected. It may be caused by the fact that the inclined disk is mainly shock-excited, whereas some fraction of the Balmer-line emission is produced by a small amount of gas excited by young stars in the main stellar disk of NGC 7743. In the circumnuclear region (R< 200 pc) some evidences of the AGN jet interaction with an ambient interstellar medium were found.
description: 11 pages, 7 figures, accepted by Astrophysical Journal
Identification and characterization of novel therapeutic targets and biomarkers in chronic myeloid leukemia
Creators: name: Lin, Hanyang
Publisher: name: University of British Columbia
Year: 2017

description: Chronic myeloid leukemia (CML) has long served as a paradigm for new insights into the cellular origin, pathogenesis and treatment of human cancers. ABL tyrosine kinase inhibitor (TKI) therapies have had remarkable effects on treatment of early phase CML. However, TKI monotherapies are not curative, and initial and acquired TKI resistance remain clinically challenging. Particularly, CML stem/progenitor cells are insensitive to TKIs. Therefore, novel treatments and predictive biomarkers are clearly needed. In this work, I studied the biological effects of dual BCR-ABL and JAK2 suppressions on TKI-nonresponder stem/progenitor cells, and identified and characterized novel microRNA (miRNA) biomarkers in these cells. I examined the biological effects of a new JAK2 inhibitor, BMS-911543, in combination with TKIs on CD34⁺ CML cells from IM-nonresponders. I demonstrated that combination therapy significantly reduces JAK2/STAT5 and CRKL activities, induces apoptosis, inhibits colony growth, and eliminates leukemic stem cells in vitro, while sparing healthy counterparts. I further showed that oral BMS-911543 combined with dasatinib is more effective in eliminating leukemic cells in an aggressive mouse model of BCR-ABL⁺ human leukemia. Next, I identified differentially expressed miRNAs in CD34⁺ CML cells using RNA-seq analysis, and validated the results in additional samples using high-throughput qPCR. Potential miRNA target genes were also identified by integrating miRNA expression profiles with gene expression profiles using strand-specific RNA-seq. These studies revealed that expression of miR-185 is significantly reduced in CD34⁺ CML cells from TKI-nonresponders compared to TKI-responders. Restoration of miR-185 expression by lentiviral transduction in CD34⁺ TKI-nonresponder cells significantly impairs survival of these cells and sensitizes them to TKI treatment in vitro and in vivo. Additionally, I validated the target genes of miR-185 to rationalize its roles in CML. Lastly, I demonstrated that the expression levels of several miRNAs, including miR185, were restored in patients treated with nilotinib, suggesting their potential as biomarkers to predict clinical response to TKI therapies. These studies have uncovered the biological significance of JAK2 and miR-185 in regulation of the properties of drug-insensitive CML stem/progenitor cells, and their potential as therapeutic targets for improved treatments with TKIs especially in patients at risk of developing TKI resistance.
Araecerus Schoenherr 1826
Creators: name: Zimmerman, Elwood C.
Publisher: name: Zenodo
Year: 1942
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Anthribidae
Araecerus

description: Genus ARAECERUS Schoenherr, 1826 This genus is predominantly ludo-Australian. The two species found in Guam have become very widespread and are readily carried by commerce. They jump rapidly when disturbed. KEY 1'0 1'HE SPECIES Segments of the antenna! club strongly asymmetrical, each almost straight on one side and strongly convex on the other (fig. 1, d), second antenna! segment usually only about half as long as the third; mesocoxae and fore tibiae of male unarmed.................................................................................. A. fasciculatus (De Geer). Segments of the antenna! club almost symmetrical, each rounded on either side (fig. 1, e), second antenna! segment about three fourths as long as the third; mesocoxae of the male with a conspicuous conical tooth; fore tibiae of the male armed below with a small but rather strong apical mucro and usually with numerous variable teeth and longer, hairlike pubescence than dorsally................ TODO TODO TODO These two species are closely allied, and greatly resemble one another. They can be separated only after detailed examination.
description: Published as part of Zimmerman, Elwood C., 1942, Anthribidae Of Guam, pp. 65-72 in Insects of Guam I, Honolulu, Hawaii :Bernice P. Bishop Museum on page 71, DOI: 10.5281/zenodo.5159835
Rank-Constrained Schur-Convex Optimization with Multiple Trace/Log-Det Constraints
Creators: name: Yu, Hao
name: Lau, Vincent K. N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Rank-constrained optimization problems have received an increasing intensity of interest recently, because many optimization problems in communications and signal processing applications can be cast into a rank-constrained optimization problem. However, due to the non-convex nature of rank constraints, a systematic solution to general rank-constrained problems has remained open for a long time. In this paper, we focus on a rank-constrained optimization problem with a Schur-convex/concave objective function and multiple trace/logdeterminant constraints. We first derive a structural result on the optimal solution of the rank-constrained problem using majorization theory. Based on the solution structure, we transform the rank-constrained problem into an equivalent problem with a unitary constraint. After that, we derive an iterative projected steepest descent algorithm which converges to a local optimal solution. Furthermore, we shall show that under some special cases, we can derive a closed-form global optimal solution. The numerical results show the superior performance of our proposed technique over the baseline schemes.
description: Some related patents are now applied. To protect our intellectual property, we postponed to make our manuscript public
GIS-gestützte Gefährdungskartierung einer alpinen Region. Georisikokarte Vorarlberg - Pilotprojekt Bregenzer Wald [online]
Creators: name: Kassebeer, Wolf
Publisher: name: Karlsruhe
Year: 2002

description: KURZFASSUNG

Im Rahmen des Projektes "Georisikokarte Vorarlberg" wurde ein
222 km² großes Gebiet in Vorarlberg/Österreich geologisch und
geo-technisch bearbeitet und teilweise neu kartiert.
Der bearbeitete Geländestreifen liegt im Bregenzerwald und zieht
sich entlang der Bregenzerach und der für den regionalen Verkehr
wichtigen Bundesstraße 200. Im Arbeitsgebiet treten Gesteine des
Penninikums, des Helvetikums und der Molasse auf. Während im
Penninikum und in der Molasse gehäuft Rutschungen auftreten,
stellt im Helvetikum Steinschlag und Felssturz die größte
Gefährdung dar.
Die erhobenen Daten wurden in einem Geoinformationssystem (GIS)
gespeichert. Als Software-Basis diente ArcInfo TM . Durch
Kombination mit amtlichen Daten wurde eine Gefährdungskartierung
durchgeführt.
Als Methode zur Beurteilung der Gefährdung durch Rutschungen im
Bereich des Penninikums und der Molasse wurde eine qualitative
Index-Methode unter Verwendung von Rasterdaten angewendet.
Für den Bereich des Helvetikums wurde die Gefährdung durch
Steinschlag und Felssturz in zwei Schritten ermittelt. Abbruch-
und Ablagerungsbereich wurden im Digitalem Geländemodell (DGM)
ermittelt. Zur Darstellung der möglichen Sturzbahnen erfolgte
eine Analyse des DGM mit dem "D8"-Verfahren.

Schlüsselwörter: Österreich, Vorarlberg, Bregenzerwald,
Hangbewegungen, Geoinformationssystem, GIS, Gefährdungsanalyse,
Gefahrenkartierung

ABSTRACT

In the course of the Project "Georisikokarte Vorarlberg" a 222
km² large area in Vorarlberg/Austria was geologically and
geotechnically examined and partly remapped.
The research area is situated in the Bregenzerwald. It is
located along the river Bregenzerach and the federal road 200 in
the stratigraphic and tectonic setting of the Penninikum, the
Helvetikum and the Molasse.
While landslides often occur in the vicinity of the Penninikum
and the Molasse, rockfalls of varying magnitude represent the
main hazard in the Helvetikum.
The collected data was stored in a geographic information system
(GIS). The software used was ArcInfo TM . A hazard mitigation
was performed using this data in combination with data obtained
from the local authorities.
To achieve this, a qualitative index method was performed for
the region of the Penninikum and the Molasse using cell-by-cell
analysis.
For the area of the Helvetikum the hazard represented by
rockfall was determined in two steps. The digital elevation
model (DEM) was used to locate the steep regions of origin and
the deposit areas. To show possible rockfall paths a flow
direction analysis from the above mentioned areas of origin was
performed using the the DEM.

keywords: Austria, Vorarlberg, landslides, rockfall,
geo-informationsystems, GIS, hazard mitigation
On the design of a combined Raman and interferometric scattering high resolution microscope
Creators: name: Christy, Ashton
Publisher: name: University of British Columbia
Year: 2016

description: Contemporary imaging science needs label-free methods of microscopy that resolve morphological and chemical information in complex materials on a sub-micron length scale. Many of the most commonly-used techniques require substantial adulteration of samples, and thus are hindered in their utility for in vivo or time-resolved studies. This thesis introduces a new approach that integrates a confocal Raman microscope with interferometric scattering, or iSCAT. The former technique is well-reported in the literature; iSCAT, however, is relatively novel. The principles of iSCAT, developed in the last few years, have established a platform that provides superior resolving power and signal contrast compared with other optical techniques. Our novel approach integrates wide-field iSCAT microscopy acquired at video rate with point-by-point confocal Raman spectroscopy. After first providing a brief overview of contemporary methods in microscopy and the challenges they present, this thesis discusses the basics of iSCAT, and the design and development of the instrument that unites this new technique with confocal Raman microscopy. A discussion of design challenges follows. Next is a description of the instrument’s user-end capabilities, followed by a brief exploration of future prospects. Provided throughout the text are results illustrating the capability of the instrument. These demonstrate how much potential the combination of iSCAT and Raman holds for characterizing complex materials, as well as the precision with which the instrument can do so. Wide-field images, 100 µm square with 200 nm resolution, are sampled at 45 frames per second. The integrated Raman probe provides label-free highly reproducible chemical information without sample degradation. Together, these two data sets provide insights into covariance between morphology and chemistry, all with minimal sample preparation.
MPEC 2025-F232 : 2025 FN14
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 FN14

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Search for a New Heavy Gauge Boson Wprime with Electron + missing ET Event Signature in ppbar collisions at sqrt(s)=1.96 TeV
Creators: name: The CDF Collaboration
name: Aaltonen, T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present a search for a new heavy charged vector boson $W^\prime$ decaying to an electron-neutrino pair in $p\bar{p}$ collisions at a center-of-mass energy of $1.96\unit{TeV}$. The data were collected with the CDF II detector and correspond to an integrated luminosity of $5.3\unit{fb}^{-1}$. No significant excess above the standard model expectation is observed and we set upper limits on $σ\cdot{\cal B}(W^\prime\to eν)$. Assuming standard model couplings to fermions and the neutrino from the $W^\prime$ boson decay to be light, we exclude a $W^\prime$ boson with mass less than $1.12\unit{TeV/}c^2$ at the $95\unit{%}$ confidence level.
description: 7 pages, 2 figures Submitted to PRL
Some Spacetimes with Higher Rank Killing-Stackel Tensors
Creators: name: Gibbons, G. W.
name: Houri, T.
name: Kubiznak, D.
name: Warnick, C. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: By applying the lightlike Eisenhart lift to several known examples of low-dimensional integrable systems admitting integrals of motion of higher-order in momenta, we obtain four- and higher-dimensional Lorentzian spacetimes with irreducible higher-rank Killing tensors. Such metrics, we believe, are first examples of spacetimes admitting higher-rank Killing tensors. Included in our examples is a four-dimensional supersymmetric pp-wave spacetime, whose geodesic flow is superintegrable. The Killing tensors satisfy a non-trivial Poisson-Schouten-Nijenhuis algebra. We discuss the extension to the quantum regime.
Potential effect of inflammation on the failure risk of in vitro fertilization and embryo transfer among infertile women
Creators: name: Xie, Jing
name: Yan, Lailai
name: Cheng, Zixi
name: Qiang, Lijuan
name: Yan, Jingjing
name: Liu, Yingying
name: Liang, Rong
name: Zhang, Jingxu
name: Li, Zhiwen
name: Zhuang, Lili
name: Hao, Cuifang
name: Wang, Bin
name: Lu, Qun
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: This study investigated the association between inflammation in infertile women and the risk of IVF-ET failure, as well as the potential effects of various lifestyles on this association. A total of 84 women undergoing IVF-ET in Beijing China were recruited, including 38 women who did not achieve pregnancy after undergoing IVF-ET and 46 women who conceived. Serum samples were collected on the second day of menstruation before the treatment cycle and the inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1)) were measured. Information about their lifestyle was collected by questionnaire. It was found that the serum IL-8 concentration in the women who did not become pregnant (cases) was significantly higher than in the women who did achieve a pregnancy (controls). A dose-response relationship between the serum IL-8 concentration and the risk of IVF-ET failure was observed, especially when the IL-8 concentration was >11.2 pg/mL. The same relationship was not found for MCP-1. Among the environmental factors investigated, only the frequency of staying up late was positively correlated with the serum IL-8 concentration, as well as positively associated with the risk of IVF-ET failure. It was concluded that excessive inflammation may have an adverse effect on the IVF-ET success rate in infertile women.
Power Allocation Strategies across N Orthogonal Channels at Both Source and Relay
Creators: name: Ko, Youngwook
name: Ardakani, Masoud
name: Vorobyov, Sergiy A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We consider a wireless relay network with one source, one relay and one destination, where communications between nodes are preformed via N orthogonal channels. This, for example, is the case when orthogonal frequency division multiplexing is employed for data communications. Since the power available at the source and relay is limited, we study optimal power allocation strategies at the source and relay in order to maximize the overall source-destination capacity under individual power constraints at the source and/or the relay. Depending on the availability of the channel state information at the source and rely, optimal power allocation strategies are performed at both the source and relay or only at the relay. Considering different setups for the problem, various optimization problems are formulated and solved. Some properties of the optimal solution are also proved.
description: 24 pages, 8 figures, submitted to the IEEE Trans. Communications in March 2010
High-resolution images of five radio quasars at early cosmological epochs
Creators: name: Frey, S.
name: Paragi, Z.
name: Gurvits, L. I.
name: Cseh, D.
name: Gabanyi, K. E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context: Until now, there have only been seven quasars at z>4.5 whose the high-resolution radio structure had been studied in detail with Very Long Baseline Interferometry (VLBI) imaging. Aims: We almost double the number of VLBI-imaged quasars at these high redshifts with the aim of studying their redshift-dependent structural and physical properties in a larger sample. Methods: We observed five radio quasars (J0813+3508, J1146+4037, J1242+5422, J1611+0844, and J1659+2101) at 4.5
description: 7 pages, 2 figures, accepted for Astronomy & Astrophysics
Araeocorynus Jekel 1855
Creators: name: Zimmerman, Elwood C.
Publisher: name: Zenodo
Year: 1942
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Anthribidae
Araeocorynus

description: Genus ARAEOCORYNUS Jekel, 1855 This genus is closely allied to Araecerus, but the upturned lateral prothotacic carina and the broad first fore tarsal segment will readily separate it from Araecerus. The genus is a small one and its members inhabit the Indo-Malayan and Austro-Malayan subregions.
description: Published as part of Zimmerman, Elwood C., 1942, Anthribidae Of Guam, pp. 65-72 in Insects of Guam I, Honolulu, Hawaii :Bernice P. Bishop Museum on page 72, DOI: 10.5281/zenodo.5159835
RG Invariants, Unification and the Role of the Messenger Scale in General Gauge Mediation
Creators: name: Jaeckel, Joerg
name: Khoze, Valentin V.
name: Wymant, Chris
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In General Gauge Mediation (GGM) all MSSM soft sfermion masses at a high scale M_mess can be parameterised by three a priori independent scales Λ_{S;1,2,3}(M_mess). (Similarly the gaugino masses are given by Λ_{G;1,2,3}(M_mess).) For the first two generations this parameterisation in terms of a set of running Λ_{S;1,2,3}(μ) -- conveniently obtained from appropriate RG invariants -- continues to hold all the way down to the electroweak scale. This is not the case for the third generation because of the large Yukawa couplings. Together these two observations imply that the messenger scale is an additional parameter of GGM models. In models where all messengers are in complete GUT multiplets (without significant mass splittings), all Λ_{S,r} are equal at M_mess. Starting from the observable mass spectrum at the electroweak scale we present a strategy to determine if this unification occurs and at which scale. This approach uses data accessible at colliders to gain insight into high scale unification physics beyond the unification of gauge couplings.
description: 17 pages, 6 figures. v2: updated Fig.1, citations added
Astronomical Oxygen Isotopic Evidence for Supernova Enrichment of the Solar System Birth Environment by Propagating Star Formation
Creators: name: Young, Edward D.
name: Gounelle, Matthieu
name: Smith, Rachel L.
name: Morris, Mark R.
name: Pontoppidan, Klaus M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: New infrared absorption measurements of oxygen isotope ratios in CO gas from individual young stellar objects confirm that the solar system is anomalously high in its 18O/17O ratio compared with extra-solar oxygen in the Galaxy. We show that this difference in oxygen isotope ratios is best explained by 1 per cent enrichment of the proto-solar molecular cloud by ejecta from type II supernovae from a cluster having of order a few hundred stars that predated the Sun by at least 10 to 20 Myr. The likely source of exogenous oxygen was the explosion of one or more B stars during a process of propagating star formation.
Effective Electromagnetic Lagrangian at Finite Temperature and Density in the Electroweak Model
Creators: name: Erdas, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Using the exact propagators in a constant magnetic field, the effective electromagnetic Lagrangian at finite temperature and density is calculated to all orders in the field strength B within the framework of the complete electroweak model, in the weak coupling limit. The partition function and free energy are obtained explicitly and the finite temperature effective coupling is derived in closed form. Some implications of this result, potentially interesting to astrophysics and cosmology, are discussed.
description: 14 pages, Revtex4
Effect of chromium disorder on the thermoelectric properties of Layered-antiferromagnet CuCrS2
Creators: name: Tewari, Girish Chandra
name: Tripathi, Tripurari Sharan
name: Rastogi, Ashok Kumar
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Layered-antiferromagnetic compound CuCrS2 has been prepared by different methods. The analysis of X-ray diffraction patterns of different samples gave significant amount of vacancy-disorder of Cr-atoms within the layers. Extended period of sintering above 9000C increases the transfer of Cr-atoms to the interstitial sites between the layers. This disorder has marginal effect on the Antiferromagnetic properties. The electrical conductivity is increased and the thermoelectric power remains positive and quite high between 150-400\muV/K in the paramagnetic state around room temperature with increase in disorder in different samples. We interpret the temperature dependence of electrical resistivity and thermoelectric power due to the localization of carriers by interstitial defects and the formation of magnetic polarons in the paramagnetic phase of CuCrS2.
Extrasolar Asteroid Mining as Forensic Evidence for Extraterrestrial Intelligence
Creators: name: Forgan, Duncan
name: Elvis, Martin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The development of civilisations like ours into spacefaring, multi-planet entities requires significant raw materials to construct vehicles and habitats. Interplanetary debris, including asteroids and comets, may provide such a source of raw materials. In this article we present the hypothesis that extraterrestrial intelligences (ETIs) engaged in asteroid mining may be detectable from Earth. Considering the detected disc of debris around Vega as a template, we explore the observational signatures of targeted asteroid mining (TAM), such as unexplained deficits in chemical species, changes in the size distribution of debris and other thermal signatures which may be detectable in the spectral energy distribution (SED) of a debris disc. We find that individual observational signatures of asteroid mining can be explained by natural phenomena, and as such they cannot provide conclusive detections of ETIs. But, it may be the case that several signatures appearing in the same system will prove harder to model without extraterrestrial involvement. Therefore signatures of TAM are not detections of ETI in their own right, but as part of "piggy-back" studies carried out in tandem with conventional debris disc research, they could provide a means of identifying unusual candidate systems for further study using other SETI techniques.
description: 15 pages, 2 figures, accepted for publication in the International Journal of Astrobiology
Oil, inflation, and financial markets
Creators: name: Jiang, Haibo
Publisher: name: University of British Columbia
Year: 2016

description: The economy’s heavy dependence on fossil energy links oil prices to real economic activities, inflation, and financial markets. This dissertation studies the extent to which fluctuations in oil prices are related to inflation and the prices and expected returns of Treasury bonds. Chapter 2 shows that the correlation between U.S. core inflation and oil price changes exhibits a time-varying pattern since the 1970s. The significant resurgence of the positive correlation after the 2007 financial crisis is puzzling, given the subdued macroeconomic impact of oil price shocks since the mid-1980s. A two-sector DSGE model illustrates that the relation between the price of oil and core inflation depends on the type of shocks embedded in oil price changes. Oil supply shocks cause the price of oil and core inflation to co-move, whereas the aggregate demand shocks driven by economic growth lead to opposing changes in the price of oil and core inflation. The economic mechanisms uncovered in the model and historical geopolitical events together provide a consistent and logical explanation of the time-varying correlations observed in the data. Chapter 3 examines the economic impact of oil prices on Treasury bond returns. I find novel evidence that growth rates of crude oil prices can explain contemporaneous excess returns on nominal U.S. Treasury bonds and inflation swaps, and also predict expected future excess returns on inflation swaps. Empirical results suggest that the impact of oil prices on nominal bonds is through the impact on expected inflation. I then build a two-sector New Keynesian model to study theoretical interactions between the economic drivers of oil prices, expected inflation, and bond yields. The model shows that oil supply and demand shocks have opposite impacts on bond yields and expected inflation. The conventional wisdom that high oil prices lead to high expected inflation and nominal yields is true only if high oil prices are driven by a negative shock to the supply of oil. In contrast, when oil prices are driven by a positive shock to productivity growth, high oil prices can lead to low expected inflation and nominal yields.
Introduction
Creators: name: Roseau, Nathalie
name: Pousin, Frédéric
Publisher: name: Collectif Inventer le Grand Paris
Year: 2018

description: Le chantier Inventer le Grand Paris et les plans Pour commencer, un constat : Pour donner une visibilité aux démarches d’aménagement du Grand Paris, notre collectif Inventer le Grand Paris avait choisi de mettre en avant, dans les quatre colloques qu’il avait organisés, les plans comme documents phares de l’urbanisme (le rapport de la commission d’extension, le PARP de 1934, le SDAURP de 1965 et le SDAURIF de 1976). Certes, il s’agissait de jouer avec des opportunités calendaires, souscrivant ainsi à une propension à célébrer les dates anniversaires. Mais nous ne croyons pas anodin d’avoir mis en exergue ces rapports, plans...
New generation electron-positron factories
Creators: name: Zobov, Mikhail
Publisher: name: arXiv
Year: 2011
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: In 2010 we celebrated 50 years since commissioning of the first particle storage ring ADA in Frascati (Italy) that also became the first electron-positron collider in 1964. After that date the particle colliders have increased their intensity, luminosity and energy by several orders of magnitude. Namely, because of the high stored beam currents and high rate of useful physics events (luminosity) the modern electron-positron colliders are called "factories". However, the fundamental physics has required luminosities by 1-2 orders of magnitudes higher with respect to those presently achieved. This task can be accomplished by designing a new generation of factories exploiting the potential of a new collision scheme based on the Crab Waist (CW) collision concept recently proposed and successfully tested at Frascati. In this paper we discuss the performance and limitations of the present generation electron-positron factories and give a brief overview of new ideas and collision schemes proposed for further collider luminosity increase. In more detail we describe the CW collision concept and the results of the crab waist collision tests in DAFNE, the Italian PHi-factory. Finally, we briefly describe most advanced projects of the next generation factories based on the CW concept: SuperB in Italy, SuperKEKB in Japan and SuperC-Tau in Russia.
description: Accepted for publication in Physics of Elementary Particles and Atomic Nuclei, written on behalf of DAFNE, SuperB and SuperC-Tau Accelerator Teams, 35 pages, 14 figures, 7 tables
The life and death of the Council of Elders of the Descendants of Jasper Park
Creators: name: Ouellet, Richard
Publisher: name: University of British Columbia
Year: 2016

description: As Indigenous rights discourse continues to advance in Canada, overarching concepts of Métis, in particular those concerning recognition and rights, continue to evolve. The micro-level or management of the relationship between Canada and small-scale Métis societies provides an opportunity to highlight issues concerning Métis/state relations. As areas such as Jasper National Park are tasked with restoring a Métis presence, how has this relationship evolved? Attempts at creating a working relationship with Métis in Jasper are confounded by uncertainty concerning Métis rights and identity. In addition, Métis are expected to abandon prior practices in organization and governance in return for access to micro-level authorities. Longstanding grievances by Métis who contend that government malfeasance resulted in their ancestors being evicted from Jasper National Park upon its inception remains hidden, as local authorities continue to find ways to marginalize Métis who are averse to participating in colonial relationships designed and controlled by micro-level authorities. Alliances with other groups with territories in National Parks, such as the Haida Nation, may provide insight and solutions. As Métis/Indigenous awareness and rights advance an important area of concern will remain in the actions of micro-level bureaucrats.