Additional file 1 of Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)
Creators: name: Wootton, Robyn E.
name: Lawn, Rebecca B.
name: Magnus, Maria C.
name: Treur, Jorien L.
name: Corfield, Elizabeth C.
name: Njølstad, Pål R.
name: Andreassen, Ole A.
name: Lawlor, Deborah A.
name: Munafò, Marcus R.
name: Håberg, Siri E.
name: Davey Smith, George
name: Reichborn-Kjennerud, Ted
name: Magnus, Per
name: Havdahl, Alexandra
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Fig. S1. An overview of participant inclusion and attrition. Fig. S2. The influence of rs16969968 genotype on reproductive outcomes. Fig. S3. MR analyses comparing first pregnancy with full sample in females. Fig. S4. MR analyses comparing first pregnancy with full sample in males. Note S1. Comparison between planning and non-planning couples. Note S2. Sensitivity analysis dichotomising time to conception. Note S3. Health behaviours and frequency of sexual intercourse. Note S4. Single-SNP analysis of rs16969968 genotype stratified by smoking status. Note S5. Power calculation for Mendelian randomisation. Note S6. MR analyses restricting to couples with first pregnancy. Note S7. Genetic instruments for educational attainment and ADHD. Table S1. Testing instrument strength of each of the polygenic risk scores. Table S2. Associations between reproductive outcomes. Table S3. Summary of characteristics comparing planners and non-planners. Table S4. Including non-planners in time to conception observational analysis. Table S5. Including non-planners in time to conception MR. Table S6. Frequency of self-reported sexual intercourse. Table S7. Observational associations between health behaviours in females. Table S8. Observational associations between health behaviours in males. Table S9. Observational associations between health behaviours in genotyped females. Table S10. Observational associations between health behaviours in genotypes males. Table S11. Individual-level Mendelian randomisation analysis in the females. Table S12. Individual-level Mendelian randomisation analysis in the males. Table S13. Evidence for assortative mating. Table S14. Evidence for reintroduced confounding. Table S15. Summary level MR sensitivity tests conducted in the MoBa sample. Table S16. Comparison of MR results in females between first pregnancy and full sample. Table S17. Comparison of MR results in males between first pregnancy and full sample. Table S18. Evidence for heterogeneity: Cochran’s Q statistics. Table S19. The MR Egger intercept test: Evidence for bias from horizontal pleiotropy. Table S20. Steiger filtering test for possible reverse causation. Table S21. Test of instrument strength and the suitability of the instrument for MR Egger. Table S22. Exploratory multivariable Mendelian randomisation.