cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: COPHYD (Corona Owed Physical Deficiency): Der Einfluss des Lockdown auf die kardiopulmonale Funktion bei kinderkardiologischen Patienten
Creators: name: Stäbler, Tim
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: CPET
subject: COVID-19
subject: CHD
subject: cardiopulmonary fitness

description: Introduction The closure of sports facilities and schools, leading to a prolonged decrease in physical activity (PA) was the result of the implementation of lockdown measures due to the COVID-19 pandemic. For maintaining cardiopulmonary function, PA plays a crucial role, which is typically assessed through peak oxygen uptake. Given that peak oxygen uptake serves as a significant predictor for mortality and morbidity, especially in children with congenital heart disease, understanding the impact of lockdowns on this parameter is of utmost importance. Methods In this study, we performed a retrospective analysis of cardiopulmonary exercise data from our patient cohort collected before and during the lockdown period. To ensure some comparability, we used a twin-pair approach in which patients were matched based on similar characteristics such as type of heart disease, age, gender and testing method. The cardiopulmonary exercise tests were performed either on a treadmill or on a bicycle. Results Our analysis included 90 pairs of twins, including 26 pairs of twins with heart disease and 19 pairs of healthy individuals. In the cohort with heart disease, we observed a significant deterioration in cardiopulmonary function, as evidenced by a decrease in ˙VO2peak (35.7 ± 9.8 vs. 30.4 ± 10.6), peak oxygen pulse (13.3 ± 4.1 vs. 11.4 ± 4.5) and peak minute ventilation (V ̇E: 83.05 ± 29.08 vs. 71.49 ± 24.96). On the other hand, healthy children showed improvements in these parameters over the same period, with a statistically significant increase observed only in peak minute ventilation (81.72 ± 25.79 vs. 97.94 ± 31.4). Conclusion Our results indicate a significant decrease in maximal oxygen uptake in patients with congenital heart disease (CHD) during lockdown. This decline was associated with impaired cardiac and pulmonary function, possibly due to restricted access to sports facilities and reduced daily physical activity due to school closures and increased parental vigilance. Conversely, lung function improved in the cohort of healthy children, suggesting a possible positive effect of increased physical activity during the lockdown.
Prospects of Detecting Non-thermal Protons in Solar Flares via Lyman Line Spectroscopy: Revisiting the Orrall-Zirker Effect
Creators: name: Kerr, Graham S.
name: Allred, Joel C.
name: Kowalski, Adam F.
name: Milligan, Ryan O.
name: Hudson, Hugh S.
name: Prado, Natalia Zambrana
name: Kucera, Therese A.
name: Brosius, Jeffrey W.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Solar flares are efficient particle accelerators, with a substantial fraction of the energy released manifesting as non-thermal particles. While the role that non-thermal electrons play in transporting flare energy is well studied, the properties and importance of non-thermal protons is rather less well understood. This is in large part due to the paucity of diagnostics, particularly at the lower-energy (deka-keV) range of non-thermal proton distributions in flares. One means to identify the presence of deka-keV protons is by an effect originally described by \cite{1976ApJ...208..618O}. In the Orrall-Zirker effect, non-thermal protons interact with ambient neutral hydrogen, and via charge exchange produce a population of energetic neutral atoms (ENAs) in the chromosphere. These ENAs subsequently produce an extremely redshifted photon in the red wings of hydrogen spectral lines. We revisit predictions of the strength of this effect using modern interaction cross-sections, and numerical models capable of self-consistently simulating the flaring non-equilibrium ionization stratification, and the non-thermal proton distribution (and, crucially, their feedback on each other). We synthesize both the thermal and non-thermal emission from \lya\ and \lyb, the most promising lines that may exhibit a detectable signal. These new predictions are are weaker and more transient than prior estimates, but the effects should be detectable in fortuitous circumstances. We degrade the \lyb\ emission to the resolution of the Spectral Imaging of the Coronal Environment (SPICE) instrument on board Solar Orbiter, demonstrating that though likely difficult, it should be possible to detect the presence of non-thermal protons in flares observed by SPICE.
description: Accepted for publication in The Astrophysical Journal
title: Methanol – n-dodecane dual-fuel direct-injection combustion under compression ignition conditions in a constant flow chamber
Creators: name: Clemente Mallada, Rafael
name: Fajri, Hamidreza
name: Rieß, Sebastian
name: Wensing, Michael
Publisher: name: International Conference on Liquid Atomization and Spray Systems
Year: 2024
Subjects: subject: Methanol
subject: dual fuel
subject: direct injection
subject: compression ignition
subject: combustion

description: This project has received funding from the European Union Horizon 2020 Research and Innovation program. Grant Agreement No. 861002.
description: This experimental work visualizes the mixture preparation, ignition, and combustion of methanol (MeOH) and n-dodecane sprays colliding at an angle of 0.42 radians at an ambient temperature of 873K and density of 23.4 kg/m³. High-speed Schlieren imaging experiments are conducted in an inert atmosphere to study the resulting mixture formation from the collision of the two vapor jets. Schlieren and OH* high-speed imaging of the flames allow for the investigation of ignition delay (ID) and heat release ratio (HRR). High-speed imaging of the natural luminosity of the flames allows for the comparison of soot production. Three distinct injection strategies are investigated: (1) injecting MeOH into a flame of the pilot fuel (PF), (2) timing both injections to reach the intersection point simultaneously, and (3) injecting the PF into an already stratified methanol plume. To study the influence of the substitution ratio, MeOH electronic injection duration is varied from 550 μs to 3000 μs, and the PF duration is shortened from 270 μs to 190 μs. PF is injected at 80MPa and 160MPa to study the influence of PF’s spray momentum compared to the MeOH spray injected at 35 MPa. Results demonstrate the possibility of sustaining a MeOH flame. Cases where the PF sprays ignite after colliding with the MeOH jet exhibit a reduction in soot production and a prolonged ID.
Multiple Cancer Testis Antigens Function To Support Tumor Cell Mitotic Fidelity
Creators: name: Taus, P.
name: Cappell, K. M.
name: Scarbrough, M.
name: Whitehurst, A. W.
name: Maxfield, K.
name: Sinnott, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: While the expression of genes that are normally involved in spermatogenesis is frequently detected in tumors, the extent to which these gene products are required for neoplastic behaviors is unclear. To begin to address their functional relevance to tumorigenesis, we identified a cohort of proteins which display synthetic lethality with paclitaxel in non-small-cell lung cancer and whose expression is biased toward testes and tumors. Remarkably, these testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells. Their individual depletion enhances the generation of multipolar spindles, increases mitotic transit time, and induces micronucleation in response to an otherwise innocuous dose of paclitaxel. The underlying basis for abnormal mitosis is an alteration in microtubule function, as their depletion increases microtubule cytaster formation and disrupts microtubule stability. Given these observations, we hypothesize that reactivated testis proteins may represent unique tumor cell vulnerabilities which, if targeted, could enhance responsiveness to antimitotic therapy. Indeed, we demonstrate that combining paclitaxel with a small-molecule inhibitor of the gametogenic and tumor cell mitotic protein TACC3 leads to enhanced centrosomal abnormalities, activation of death programs, and loss of anchorage-independent growth.
The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector
Creators: name: Martin, T. D.
name: Neel, N. F.
name: Rossman, K. L.
name: Der, C. J.
name: Hayes, T. K.
name: Yeh, J. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Our recent studies implicated key and distinct roles for the highly related RalA and RalB small GTPases (82% sequence identity) in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and invasive and metastatic growth, respectively. How RalB may promote PDAC invasion and metastasis has not been determined. In light of known Ral effector functions in regulation of actin organization and secretion, we addressed a possible role for RalB in formation of invadopodia, actin-rich membrane protrusions that contribute to tissue invasion and matrix remodeling. We determined that a majority of KRAS mutant PDAC cell lines exhibited invadopodia and that expression of activated K-Ras is both necessary and sufficient for invadopodium formation. Invadopodium formation was not dependent on the canonical Raf-MEK-ERK effector pathway and was instead dependent on the Ral effector pathway. However, this process was more dependent on RalB than on RalA. Surprisingly, RalB-mediated invadopodium formation was dependent on RalBP1/RLIP76 but not Sec5 and Exo84 exocyst effector function. Unexpectedly, the requirement for RalBP1 was independent of its best known function as a GTPase-activating protein for Rho small GTPases. Instead, disruption of the ATPase function of RalBP1 impaired invadopodium formation. Our results identify a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation.
title: Best of both worlds: Combining predictive power with interpretable and explainable results for patient pathway prediction
Creators: name: Zilker, Sandra
name: Weinzierl, Sven
name: Zschech, Patrick
name: Kraus, Mathias
name: Matzner, Martin
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2023
Subjects: subject: Patient pathway prediction
subject: Predictive business process monitoring
subject: Explainable artificial intelligence
subject: Interpretable artificial intelligence
subject: Deep neural networks
subject: Business process management

description: ISSN: https://aisel.aisnet.org/ecis2023_rp/266
description: Proactively analyzing patient pathways can help healthcare providers to anticipate treatment-related risks, detect undesired outcomes, and allocate resources quickly. For this purpose, modern methods from the field of predictive business process monitoring can be applied to create data-driven models that capture patterns from past behavior to provide predictions about running process instances. Recent methods increasingly focus on deep neural networks (DNN) due to their superior prediction performances and their independence from process knowledge. However, DNNs generally have the disadvantage of showing black-box characteristics, which hampers the dissemination in critical environments such as healthcare. To this end, we propose the design of HIXPred, a novel artifact combining predictive power with explainable results for patient pathway predictions. We instantiate HIXPred and apply it to a real-life healthcare use case for evaluation and demonstration purposes and conduct interviews with medical experts. Our results confirm high predictive performance while ensuring sufficient interpretability and explainability to provide comprehensible decision support.
MicroRNA 9-3p Targets 1 Integrin To Sensitize Claudin-Low Breast Cancer Cells to MEK Inhibition
Creators: name: Parker, J. S.
name: Zawistowski, J. S.
name: Golitz, B. T.
name: Nakamura, K.
name: Granger, D. A.
name: Johnson, G. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: MEK1/2 inhibitors such as AZD6244 are in clinical trials for the treatment of multiple cancers, including breast cancer. Targeted kinase inhibition can induce compensatory kinome changes, rendering single therapeutic agents ineffective. To identify target proteins to be used in a combinatorial approach to inhibit tumor cell growth, we used a novel strategy that identified microRNAs (miRNAs) that synergized with AZD6244 to inhibit the viability of the claudin-low breast cancer cell line MDA-MB-231. Screening of a miRNA mimic library revealed the ability of miR-9-3p to significantly enhance AZD6244-induced extracellular signal-regulated kinase inhibition and growth arrest, while miR-9-3p had little effect on growth alone. Promoter methylation of mir-9 genes correlated with low expression of miR-9-3p in different breast cancer cell lines. Consistent with miR-9-3p having synthetic enhancer tumor suppressor characteristics, miR-9-3p expression in combination with MEK inhibitor caused a sustained loss of c-MYC expression and growth inhibition. The β1 integrin gene (ITGB1) was identified as a new miR-9-3p target, and the growth inhibition seen with small interfering RNA knockdown or antibody blocking of ITGB1 in combination with MEK inhibitor phenocopied the growth inhibition seen with miR-9-3p plus AZD6244. The miRNA screen led to identification of a druggable protein, ITGB1, whose functional inhibition synergizes with MEK inhibitor.
Circularly Polarized Attosecond Pulses and Molecular Atto-Magnetism
Creators: name: Bandrauk, Andre D.
name: Yuan, Kai-Jun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Various schemes are presented for the generation of circularly polarized molecular high-order harmonic generation (MHOHG) from molecules. In particular it is shown that combinations of counter-rotating circularly polarized pulses produce the lowest frequency Coriolis forces with the highest frequency recollisions, thus generating new harmonics which are the source of circular polarized attosecond pulses (CPAPs). These can be used to generate circularly polarized electronic currents in molecular media on attosecond time scale. Molecular attosecond currents allow then for the generation of ultrashort magnetic field pulses on the attosecond time scale, new tools for molecular atto-magnetism (MOLAM).
description: Book Chapter
Application of response surface methodology on brewery wastewater treatment using chitosan as a coagulant.
Creators: name: Mangena Khumalo, Siphesihle
name: Femi Bakare, Babatunde
name: Kweinor Tetteh, Emmanuel
name: Rathilal, Sudesh
Publisher: name: Mangosuthu University of Technology (MUT)
Year: 2023
Subjects: Wastewater treatment processes
Water treatment processes

description: Brewery wastewater (BWW) treatment seems to be challenging for conventional wastewater treatment processes. Hence, different processes (i.e., biological, physical, chemical, and advanced oxidation processes) have been investigated; however, reports on parametric optimization using statistical tools are scant. In this present study, the potential application of chitosan as a biopolymer coagulant in decontaminating BWW was investigated. Operating conditions were optimised using the central composite design in response surface methodology (RSM) with 16 experimental runs. The effect of process variables, i.e., pH (4–8), chitosan dose (2–4) g/L and contact time (15–45 min) on the removal of turbidity, total organic carbon (TOC), and orthophosphates were investigated. Experimental results obtained were statistically analysed using the analysis of variance (ANOVA) and second-order polynomial response predictive models as functions of input variables with a significant regression coefficient of R2 > 0.95 at 95% confidence were obtained. At numerical optimum conditions of pH (8), chitosan dose (2 g/L), and contact time (43 min), validation experimental responses of 91% turbidity, 89% TOC, and 65% orthophosphate removals were obtained at a standard deviation of ±0.588, ±0.395, and ±3.603, respectively. The validation results at optimum conditions suggest that proper adjustment of pH, chitosan dose, and contact time is imperative for maximising the efficiency of chitosan in treating BWW. Moreover, the findings of the current study demonstrate that chitosan can be used as a viable bio-coagulant in BWW treatment prior to being discharged into water receiving bodies.
Additional file 1 of Pathogenicity and vaccine efficacy of two virulent infectious laryngotracheitis virus strains in Egypt
Creators: name: El-Saied, Mohamed
name: El-Mahdy, Magdy M.
name: Bayoumi, Mahmoud
name: Soliman, Reem A.
name: Elsayed, Marwa. F.
name: Sakr, Ezz El-Din
name: Bastami, Mostafa
name: El-Safty, Munir M.
name: Shaalan, Mohamed
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Supplementary Figure. Microphotograph is showing normal chicken embryo fibroblast (CEF) in the negative control while the positive ILTV infected CEF is showing cytopathic effect of the virus manifested by clumps and aggregates of cells (circle).
Dynamic frequency dependence of bias activated negative capacitance in semiconductor diodes under high forward bias
Creators: name: Bansal, Kanika
name: Henini, Mohamed
name: Alshammari, Marzook S.
name: Datta, Shouvik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We observed qualitatively dissimilar frequency dependence of negative capacitive response under high charge injection in two sets of junction diodes which are functionally different from each other i.e. electroluminescent diodes and non-luminescent Si-based diodes. Using the technique of bias-activated differential capacitance response, we investigated the mutual dynamics of different rate processes in different diodes. We explain these observations as the mutual competition of fast and slow electronic transition rates albeit differently. This study provides a better understanding of the physics of junction diodes operating under high charge carrier injection and may lead to superior device functionalities.
description: 13 pages, 3 sets of figures
SWI/SNF Chromatin-Remodeling Factor Smarcd3/Baf60c Controls Epithelial-Mesenchymal Transition by Inducing Wnt5a Signaling
Creators: name: Johnson, G. L.
name: Perou, C. M.
name: Golitz, B. T.
name: Jordan, N. V.
name: Prat, A.
name: Abell, A. N.
name: Zhou, B.
name: Sciaky, N.
name: Zawistowski, J. S.
name: Karginova, O. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We previously identified a gene signature predicted to regulate the epithelial-mesenchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells. A phenotypic RNA interference (RNAi) screen identified the genes within this 140-gene signature that promoted the conversion of mesenchymal epithelial cell adhesion molecule-negative (EpCAM−) breast cancer cells to an epithelial EpCAM+/high phenotype. The screen identified 10 of the 140 genes whose individual knockdown was sufficient to promote EpCAM and E-cadherin expression. Among these 10 genes, RNAi silencing of the SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c in EpCAM− breast cancer cells gave the most robust transition from the mesenchymal to epithelial phenotype. Conversely, expression of Smarcd3/Baf60c in immortalized human mammary epithelial cells induced an EMT. The mesenchymal-like phenotype promoted by Smarcd3/Baf60c expression resulted in gene expression changes in human mammary epithelial cells similar to that of claudin-low triple-negative breast cancer cells. These mammary epithelial cells expressing Smarcd3/Baf60c had upregulated Wnt5a expression. Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3/Baf60c-induced EMT. Thus, Smarcd3/Baf60c epigenetically regulates EMT by activating WNT signaling pathways.
A fully relativistic radial fall
Creators: name: Spallicci, Alessandro D. A. M.
name: Ritter, Patxi
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Mathematical Physics (math-ph)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Radial fall has historically played a momentous role. It is one of the most classical problems, the solutions of which represent the level of understanding of gravitation in a given epoch. A {\it gedankenexperiment} in a modern frame is given by a small body, like a compact star or a solar mass black hole, captured by a supermassive black hole. The mass of the small body itself and the emission of gravitational radiation cause the departure from the geodesic path due to the back-action, that is the self-force. For radial fall, as any other non-adiabatic motion, the instantaneous identity of the radiated energy and the loss of orbital energy cannot be imposed and provide the perturbed trajectory. In the first part of this letter, we present the effects due to the self-force computed on the geodesic trajectory in the background field. Compared to the latter trajectory, in the Regge-Wheeler, harmonic and all others smoothly related gauges, a far observer concludes that the self-force pushes inward (not outward) the falling body, with a strength proportional to the mass of the small body for a given large mass; further, the same observer notes an higher value of the maximal coordinate velocity, this value being reached earlier on during infall. In the second part of this letter, we implement a self-consistent approach for which the trajectory is iteratively corrected by the self-force, this time computed on osculating geodesics. Finally, we compare the motion driven by the self-force without and with self-consistent orbital evolution. Subtle differences are noticeable, even if self-force effects have hardly the time to accumulate in such a short orbit.
description: To appear in Int. J. Geom. Meth. Mod. Phys
Escape distribution for an inclined billiard
Creators: name: Roy, Alan
name: Georgakarakos, Nikolaos
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: H${\acute{e}}$non [8] used an inclined billiard to investigate aspects of chaotic scattering which occur in satellite encounters and in other situations. His model consisted of a piecewise mapping which described the motion of a point particle bouncing elastically on two disks. A one parameter family of orbits, named h-orbits, was obtained by starting the particle at rest from a given height. We obtain an analytical expression for the escape distribution of the h-orbits, which is also compared with results from numerical simulations. Finally, some discussion is made about possible applications of the h-orbits in connection with Hill's problem.
description: This is a preprint of a paper published in 'Regular and Chaotic Dynamics' in 2012
Magnetic activity variability from H$α$ line intensive monitoring for two F-type stars having a hot-Jupiter, $τ$ Bootis A and $\upsilon$ Andromedae A
Creators: name: Lee, Sanghee
name: Notsu, Yuta
name: Sato, Bun'ei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the results of intensive monitoring of the variability in the H$α$ line for two F-type stars, $τ$ Boo and $\upsilon$ And, during the last four years 2019-2022, in order to investigate their stellar magnetic activity. The 4-year H$α$ line intensity data taken with the 1.88-m reflector at Okayama Branch Office, Subaru Telescope, shows the existence of a possible $\sim$ 123-day magnetic activity cycle of $τ$ Boo. The result of the H$α$ variability as another tracer of the magnetic activity on the chromosphere is consistent with previous studies of the Ca II H&K line and suggests that the magnetic activity cycle is persisted in $τ$ Boo. For $\upsilon$ And, we suggest a quadratic long-term trend in the H$α$ variability. Meanwhile, the short-term monitoring shows no significant period corresponding to specific variations likely induced by their hot-Jupiter in both cases ($\approx$ 3.31 and 4.62 days, respectively). In this H$α$ observation, we could not find any signature of the Star-Planet Magnetic Interaction. It is speculated that the detected magnetic activity variability of the two F-type stars is related to the stellar intrinsic dynamo.
description: 27 pages, 20 figures, 1 table, Accepted by Publications of the Astronomical Society of Japan
Additional file 1 of Comparison of the predictive value of four insulin resistance surrogates for the prevalence of hypertension: a population-based study
Creators: name: Cheng, Wenke
name: Kong, Fanliang
name: Chen, Siwei
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file1:Table S1. Baseline information of the overall population after multiple imputation *.Table S2. Multivariable logistic regression of four IR surrogates and the prevalence of hypertension after multiple imputation. Table S3. Predictive value of four IR substitutes for the prevalence of hypertension after multiple imputation. Figure S1. Bayesian network model of hypertension prevalence and all clinical characteristics after multiple imputation. Figure S2. Bayesian network model of hypertension prevalence and four IR surrogates-related characteristics after multiple imputation.
Brief an [Cäsar] von Arx
Creators: name: Geigy-Hagenbach, Karl
Publisher: name: [s.n.]
Year: 1949

description: von K[arl] Geigy Hagenbach
description: Datum evtl. auch 29.04.1949
description: Deutsch
description: Verzeichnung=Description=Inventaire Juni 2022 HAN-Katalogisierungsregeln HBr
The Cryptococcus neoformans Rim101 Transcription Factor Directly Regulates Genes Required for Adaptation to the Host
Creators: name: Selvig, K. M.
name: Alspaugh, J. A.
name: Mitchell, A. P.
name: Xu, W.
name: O'Meara, T. R.
name: O'Meara, M. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The Rim101 protein is a conserved pH-responsive transcription factor that mediates important interactions between several fungal pathogens and the infected host. In the human fungal pathogen Cryptococcus neoformans, the Rim101 protein retains conserved functions to allow the microorganism to respond to changes in pH and other host stresses. This coordinated cellular response enables this fungus to effectively evade the host immune response. Preliminary studies suggest that this conserved transcription factor is uniquely regulated in C. neoformans both by the canonical pH-sensing pathway and by the cyclic AMP (cAMP)/protein kinase A (PKA) pathway. Here we present comparative transcriptional data that demonstrate a strong concordance between the downstream effectors of PKA and Rim101. To define Rim101-dependent gene expression during a murine lung infection, we used nanoString profiling of lung tissue infected with a wild-type or rim101Δ mutant strain. In this setting, we demonstrated that Rim101 controls the expression of multiple cell wall-biosynthetic genes, likely explaining the enhanced immunogenicity of the rim101Δ mutant. Despite its divergent upstream regulation, the C. neoformans Rim101 protein recognizes a conserved DNA binding motif. Using these data, we identified direct targets of this transcription factor, including genes involved in cell wall regulation. Therefore, the Rim101 protein directly controls cell wall changes required for the adaptation of C. neoformans to its host environment. Moreover, we propose that integration of the cAMP/PKA and pH-sensing pathways allows C. neoformans to respond to a broad range of host-specific signals.
Guia PAT Docents 3 Sessions Alfabetització digital crítica - Universitat de Barcelona x Institut Pedralbes
Creators: name: Jiménez Torras, Dídac
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 390307
subject: Teacher education and professional development of educators
classificationCode: 360502
subject: Computer gaming and animation

description: ENG: This resource is meant to be used by teachers of high school students (15–16 years) in three 1-hour sessions to learn media literacy. The teachers may look at these in addition to their instructions. The resources were made in 2024; they have been revised and iterated 0 times since.CAT: Aquest recurs està pensat per ser utilitzat pe docents d'estudiants d'institut (3–4 ESO) en tres sessions d'1 hora per aprendre l'alfabetització digital crítica. Els professors poden mirar els documents a més de les seves instruccions. Els recursos es van fer l'any 2024; des d'aleshores s'han revisat i actualitzat 0 vegades.
Additional file 1 of Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis
Creators: name: Hajifoghaha, Mahboubeh
name: Teshnizi, Saeed Hosseini
name: Forouhari, Sedighe
name: Dabbaghmanesh, Mohammad Hossein
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplemental appendix 1. PRISMA 2020 Checklist.
The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination
Creators: name: Patterson, Cam
name: McDonough, Holly
name: Ronnebaum, Sarah M.
name: Wu, Yaxu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ubiquitin ligase CHIP (carboxyl terminus of Hsp70-interacting protein) regulates protein quality control, and CHIP deletion accelerates aging and reduces the life span in mice. Here, we reveal a mechanism for CHIP's influence on longevity by demonstrating that CHIP stabilizes the sirtuin family member SirT6, a lysine deacetylase/ADP ribosylase involved in DNA repair, metabolism, and longevity. In CHIP-deficient cells, SirT6 protein half-life is substantially reduced due to increased proteasome-mediated degradation, but CHIP overexpression in these cells increases SirT6 protein expression without affecting SirT6 transcription. CHIP noncanonically ubiquitinates SirT6 at K170, which stabilizes SirT6 and prevents SirT6 canonical ubiquitination by other ubiquitin ligases. In CHIP-depleted cells, SirT6 K170 mutation increases SirT6 half-life and prevents proteasome-mediated degradation. The global decrease in SirT6 expression in the absence of CHIP is associated with decreased SirT6 promoter occupancy, which increases histone acetylation and promotes downstream gene transcription in CHIP-depleted cells. Cells lacking CHIP are hypersensitive to DNA-damaging agents, but DNA repair and cell viability are rescued by enforced expression of SirT6. The discovery of this CHIP-SirT6 interaction represents a novel protein-stabilizing mechanism and defines an intersection between protein quality control and epigenetic regulation to influence pathways that regulate the biology of aging.
p19Ink4d Is a Tumor Suppressor and Controls Pituitary Anterior Lobe Cell Proliferation
Creators: name: Chan, H. L.
name: Pei, X.-H.
name: Bai, F.
name: Kiyokawa, H.
name: Smith, M. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Pituitary tumors develop in about one-quarter of the population, and most arise from the anterior lobe (AL). The pituitary gland is particularly sensitive to genetic alteration of genes involved in the cyclin-dependent kinase (CDK) inhibitor (CKI)–CDK-retinoblastoma protein (Rb) pathway. Mice heterozygous for the Rb mutation develop pituitary tumors, with about 20% arising from the AL. Perplexingly, none of the CKI-deficient mice reported thus far develop pituitary AL tumors. In this study, we show that deletion of p19Ink4d (p19), a CKI gene, in mice results in spontaneous development of tumors in multiple organs and tissues. Specifically, more than one-half of the mutant mice developed pituitary hyperplasia or tumors predominantly in the AL. Tumor development is associated with increased cell proliferation and enhanced activity of Cdk4 and Cdk6 and phosphorylation of Rb protein. Though Cdk4 is indispensable for postnatal pituitary cell proliferation, it is not required for the hyperproliferative pituitary phenotype caused by p19 loss. Loss of p19 phosphorylates Rb in Cdk4−/− pituitary AL cells and mouse embryonic fibroblasts (MEFs) and rescues their proliferation defects, at least partially, through the activation of Cdk6. These results provide the first genetic evidence that p19 is a tumor suppressor and the major CKI gene that controls pituitary AL cell proliferation.
Additional file 2 of Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis
Creators: name: Hajifoghaha, Mahboubeh
name: Teshnizi, Saeed Hosseini
name: Forouhari, Sedighe
name: Dabbaghmanesh, Mohammad Hossein
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 2: Supplemental appendix 2. Electronic database search strings.
Deficit of primitive compositions in binary asteroids and pairs
Creators: name: Minker, Kate
name: Carry, Benoît
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Context. Small binary asteroid systems and pairs are thought to form through fission induced by spin up via the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect. This process is expected to depend on their structural strength, hence composition. Aims. We aim to determine how taxonomic classes, used as a proxy for composition, distribute amongst binary asteroids and asteroid pairs compared to the general population. Methods. We compare the distribution of taxonomic classes of binary systems and pairs with that of a reference sample of asteroids. We build this sample by selecting asteroids to reproduce the orbital and size distribution of the binaries and pairs to minimize potential biases between samples. Results. A strong deficit of primitive compositions (C, B, P, D types) among binary asteroids and asteroid pairs is identified, as well as a strong excess of asteroids with mafic-silicate rich surface compositions (S, Q, V, A types). Conclusions. Amongst low mass, rapidly rotating asteroids, those with mafic-silicate rich compositions are more likely to form multiple asteroid systems than their primitive counterparts.
description: 12 pages, 7 figures, last 5 pages are tables
PMU based Detection of Imbalance in Three-Phase Power Systems
Creators: name: Routtenberg, Tirza
name: Xie, Yao
name: Willett, Rebecca M.
name: Tong, Lang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: The problem of imbalance detection in a three-phase power system using a phasor measurement unit (PMU) is considered. A general model for the zero, positive, and negative sequences from a PMU measurement at off-nominal frequencies is presented and a hypothesis testing framework is formulated. The new formulation takes into account the fact that minor degree of imbalance in the system is acceptable and does not indicate subsequent interruptions, failures, or degradation of physical components. A generalized likelihood ratio test (GLRT) is developed and shown to be a function of the negative-sequence phasor estimator and the acceptable level of imbalances for nominal system operations. As a by-product to the proposed detection method, a constrained estimation of the positive and negative phasors and the frequency deviation is obtained for both balanced and unbalanced situations. The theoretical and numerical performance analyses show improved performance over benchmark techniques and robustness to the presence of additional harmonics.
description: Accepted to IEEE Trans. on Power System Sep. 2014
Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase
Creators: name: Major, Michael B.
name: Goldfarb, Dennis
name: Kim, Tai Young
name: Moon, Randall T.
name: Yi, XianHua
name: Yan, Feng
name: MacCoss, Michael J.
name: Mackinnon, Kathryn
name: Siesser, Priscila F.
name: Rossman, Kent L.
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Defining the full complement of substrates for each ubiquitin ligase remains an important challenge. Improvements in mass spectrometry instrumentation and computation and in protein biochemistry methods have resulted in several new methods for ubiquitin ligase substrate identification. Here we used the parallel adapter capture (PAC) proteomics approach to study βTrCP2/FBXW11, a substrate adaptor for the SKP1–CUL1–F-box (SCF) E3 ubiquitin ligase complex. The processivity of the ubiquitylation reaction necessitates transient physical interactions between FBXW11 and its substrates, thus making biochemical purification of FBXW11-bound substrates difficult. Using the PAC-based approach, we inhibited the proteasome to “trap” ubiquitylated substrates on the SCFFBXW11E3 complex. Comparative mass spectrometry analysis of immunopurified FBXW11 protein complexes before and after proteasome inhibition revealed 21 known and 23 putatively novel substrates. In focused studies, we found that SCFFBXW11bound, polyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1. High RAPGEF2 protein levels promoted cell-cell fusion and, consequently, multinucleation. Surprisingly, this occurred independently of the guanine nucleotide exchange factor (GEF) catalytic activity and of the presence of RAP1. Our data establish new functions for RAPGEF2 that may contribute to aneuploidy in cancer. More broadly, this report supports the continued use of substrate trapping proteomics to comprehensively define targets for E3 ubiquitin ligases. All proteomic data are available via ProteomeXchange with identifier PXD001062.
Additional file 3 of Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis
Creators: name: Hajifoghaha, Mahboubeh
name: Teshnizi, Saeed Hosseini
name: Forouhari, Sedighe
name: Dabbaghmanesh, Mohammad Hossein
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 3: Supplemental appendix 3. Studies rejected at full-text review stage.
SCORE D6.3 - Exposure database and vulnerability curves for the frontrunners CCLLs.
Creators: name: Figueiredo, Rui
name: Raymundo Rangel
Publisher: name: Zenodo
Year: 2022

description: The present demonstrator (D6.3), together with the corresponding exposure and vulnerability assessment methodology report (D6.2), were developed in the context of WP6’s Task 6.2. These outputs will be used in the development of Task 6.3, where quantitative risk assessments will be performed for the CCLLs based on exposure, vulnerability and hazard data. Regarding the latter, there is therefore a further linkage with WP3’s deliverable D3.7 - "Package of short-term hazard modelling", which together with the proposed exposure models and vulnerability assessment methodologies of the present D6.2, will serve to produce the results concerning D6.4 "Residual risk assessment report for the frontrunner CCLLs".  The development of the exposure database was linked to the previous activity from WP2 "CCLL questionnaires", where the first information on the elements and exposure characteristics of the CCLL frontrunners was delivered. Another activity related with the development of the exposure models was the definition of the study areas provided by the CCLLs with the support of WP3.
Chase-escape in dynamic device-to-device networks
Creators: name: Hinsen, Alexander
name: Jahnel, Benedikt
name: Cali, Elie
name: Wary, Jean-Philippe
Publisher: name: Weierstrass Institute
Year: 2022
Subjects: subject: Cox point processes
subject: random graphs
subject: mobility
subject: random waypoint model
subject: percolation
subject: 60J25
subject: 60K35
subject: 60K37

description: The present paper features results on global survival and extinction of an infection in a multi-layer network of mobile agents. Expanding on a model first presented in CHJW22, we consider an urban environment, represented by line-segments in the plane, in which agents move according to a random waypoint model based on a Poisson point process. Whenever two agents are at sufficiently close proximity for a sufficiently long time the infection can be transmitted and then propagates into the system according to the same rule starting from a typical device. Inspired by wireless network architectures, the network is additionally equipped with a second class of agents that is able to transmit a patch to neighboring infected agents that in turn can further distribute the patch, leading to a chase-escape dynamics. We give conditions for parameter configurations that guarantee existence and absence of global survival as well as an in-and-out of the survival regime, depending on the speed of the devices. We also provide complementary results for the setting in which the chase-escape dynamics is defined as an independent process on the connectivity graph. The proofs mainly rest on percolation arguments via discretization and multiscale analysis.
Brief an [Cäsar] von Arx
Creators: name: Geigy-Hagenbach, Karl
Publisher: name: [s.n.]
Year: 1948

description: von K[arl] Geigy Hagenbach
description: Autograf
description: Deutsch
description: Verzeichnung=Description=Inventaire Juni 2022 HAN-Katalogisierungsregeln HBr
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: «Il menabò» di Vittorini e Calvino è uno strumento di orientamento e di verifica delle tendenze letterarie della seconda metà del Novecento. La rivista consta di dieci numeri pubblicati dal 1959 al 1967. Il titolo allude allo strumento della realizzazione grafica di un lavoro editoriale. Un nome legato ad un’idea di funzionalità che pone in primo piano l’intento tutt’altro che dogmatico della rivista. Ciò che muove i direttori è l’analisi delle trasformazioni sociali ed economiche attraverso cui si manifesta la modernità. Il proposito del numero 4 de «Il menabò» è quello di interrogarsi continuamente al fine di dare risposte concrete alla ricerca di una reale visione di un mondo ancora «imposseduto».
description: «Il menabò» by Vittorini and Calvino is an instrument of orientation and verification of the literary trends of the second half of the twentieth century. The magazine consists of ten volumes published from 1959 to 1967. The title refers to the tool of the graphic realization during an editorial work. The title of magazine is linked to an idea of functionality that is the magazine's main focus, far from any dogmatic intent. The purpose of directors is the analysis of the social and economic transformations through the modernity and how it’s manifested. The result of number 4 of «Il menabò» is questioning about the possibility of giving concrete answers and a real vision of a world that is still «not possessed».
Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer
Creators: name: Grossman, Gail
name: Bai, Suxia
name: Pop, Elena A.
name: Smith, Gary J.
name: French, Frank S.
name: Harris Ford, O.
name: Titus, Mark A.
name: Mohler, James L.
name: Wilson, Elizabeth M.
name: Tan, Jiann-an
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The transcription factor coregulator Casein kinase IIβbinding protein 2 or CR6-interacting factor 1 (CKβBP2/CRIF1) binds the androgen receptor (AR) in prostate cancer cells and in response to dihydrotestosterone localizes with AR on the prostate-specific antigen gene enhancer, but does not bind DNA suggesting CKβBP2/CRIF1 localization in chromatin is determined by AR. In this study we show also that CKβBP2/CRIF1 inhibits wild-type AR and AR N-terminal transcriptional activity, binds to the AR C-terminal region, inhibits interaction of the AR N- and C-terminal domains (N/C interaction) and competes with p160 coactivator binding to the AR C-terminal domain, suggesting CKβBP2/CRIF1 interferes with AR activation functions 1 and 2. CKβBP2/CRIF1 is expressed mainly in stromal cells of benign prostatic hyperplasia and in stroma and epithelium of prostate cancer. CKβBP2/CRIF1 protein is increased in epithelium of androgen-dependent prostate cancer compared to benign prostatic hyperplasia and decreased slightly in castration recurrent epithelium compared to androgen-dependent prostate cancer. The multifunctional CKβBP2/CRIF1 is a STAT3 interacting protein and reported to be a coactivator of STAT3. CKβBP2/CRIF1 is expressed with STAT3 in prostate cancer where STAT3 may help to offset the AR repressor effect of CKβBP2/CRIF1 and allow AR regulation of prostate cancer growth.