cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Exporting and Investment Under Credit Constraints
Creators: name: Huynh, Kim
name: Petrunia, Robert J.
name: Rodrigue, Joel
name: Steingress, Walter
Publisher: name: Bank of Canada
Year: 2023

description: We examine the relationship between firms’ performance and credit constraints affecting export market entry. The existing research assumes that variation in firms’ financial conditions identifies credit constraints. A critical assumption is that financial conditions do not affect real outcomes (performance, exporting, or investment). To relax this assumption, we focus on the direct effect of firms’ fundamentals and financial conditions on firms’ performance. This approach distinguishes between firms that choose not to export because it is unprofitable from firms that do not export because of binding credit constraints. Our empirical specification allows firms’ characteristics to enter both the selection into exporting and return from exporting regressions. The leverage response heterogeneity identifies the presence of credit constraints. Using administrative Canadian firm-level data, our findings show that new exporters (a) increase their productivity, (b) raise their leverage ratio and (c) increase investment. We estimate that 48 percent of Canadian manufacturers face binding credit constraints when deciding whether to enter export markets. Alleviating these constraints would increase aggregate productivity by 0.97–1.04 percentage points.
description: Nous examinons la relation entre le rendement des entreprises et les contraintes de crédit touchant l’entrée sur les marchés d’exportation. La recherche actuelle suppose que la variation des conditions financières d’une entreprise est indicative de contraintes de crédit. Une hypothèse fondamentale est que les conditions financières n’ont pas d’effet sur les résultats réels (rendement, exportation ou investissement). Pour affaiblir cette hypothèse, nous nous concentrons sur les effets directs des facteurs fondamentaux et des conditions financières d’une entreprise sur son rendement. Par cette approche, nous établissons une distinction entre les entreprises qui choisissent de ne pas exporter parce que ce n’est pas rentable et celles qui n’exportent pas en raison de contraintes de crédit actives. Notre spécification empirique tient compte des caractéristiques des entreprises dans les régressions à la décision d’exporter et au rendement des exportations. L’hétérogénéité de la réponse obtenue dénote la présence de contraintes de crédit. À partir de données administratives sur les entreprises canadiennes, nos conclusions montrent que les nouveaux exportateurs : a) accroissent leur productivité, b) augmentent leur ratio de levier et c) haussent leurs investissements. Nous estimons que 48 % des fabricants canadiens éprouvent des contraintes de crédit actives lorsqu’ils décident de s’engager dans les marchés d’exportation. En atténuant ces contraintes, il serait possible d’accroître la productivité globale de 0,97 à 1,04 point de pourcentage.
Planes of satellite galaxies and the cosmic web
Creators: name: Libeskind, Noam I.
name: Hoffman, Yehuda
name: Tully, R. Brent
name: Courtois, Helene M.
name: Pomarede, Daniel
name: Gottloeber, Stefan
name: Steinmetz, Matthias
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent observational studies have demonstrated that the majority of satellite galaxies tend to orbit their hosts on highly flattened, vast, possibly co-rotating planes. Two nearly parallel planes of satellites have been confirmed around the M31 galaxy and around the Centaurus A galaxy, while the Milky Way also sports a plane of satellites. It has been argued that such an alignment of satellites on vast planes is unexpected in the standard (ΛCDM) model of cosmology if not even in contradiction to its generic predictions. Guided by ΛCDM numerical simulations, which suggest that satellites are channeled towards hosts along the axis of the slowest collapse as dictated by the ambient velocity shear tensor, we re-examine the planes of local satellites systems within the framework of the local shear tensor derived from the Cosmicflows-2 dataset. The analysis reveals that the Local Group and Centaurus A reside in a filament stretched by the Virgo cluster and compressed by the expansion of the Local Void. Four out of five thin planes of satellite galaxies are indeed closely aligned with the axis of compression induced by the Local Void. Being the less massive system, the moderate misalignment of the Milky Way's satellite plane can likely be ascribed to its greater susceptibility to tidal torques, as suggested by numerical simulations. The alignment of satellite systems in the local universe with the ambient shear field is thus in general agreement with predictions of the ΛCDM model.
description: 9 pages, 3 figures, 3 tables. Accepted by MNRAS, 9 June 2015
How does economic policy uncertainty influence the timeliness of goodwill impairment? ─ Australian evidence
Creators: name: Shi, Yi
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis investigates the effect of economic policy uncertainty (EPU) on the timeliness of goodwill impairment of Australian listed firms from 2006 to 2019. Using the EPU index developed by Baker, Bloom, and Davis (2016), this thesis builds a multivariate logistic regression model to estimate the effect of EPU on the timeliness of corporate goodwill impairment. The analyses show that EPU attenuates the timeliness of goodwill impairment, and this attenuating effect is robust to different model specifications. The thesis then employs cross-sectional analyses to examine whether the attenuating effect of EPU varies with firms’ life cycle, firms’ severity of financial constraints, and the geographic location of firms’ headquarters. The results reveal that the negative effect of EPU is driven by mature firms, firms with severe financial constraints, and firms located in small states of Australia. Against the backdrop of a gubernatorial election triggering economic policy-related uncertainty, the thesis conducts a difference-in-differences test, and the results corroborate the main finding. The thesis also performs a Two-Stage Least Square regression test to alleviate the concerns about potential endogeneity due to omitted variables. Furthermore, to alleviate the concern about measurement errors, the thesis adopts a two-step regression approach to remove other non-policy-related factors from the original EPU measure and uses the residuals of the estimation as an alternative measure of EPU for a sensitivity test. The main results are also robust to a battery of additional sensitivity tests, such as controlling for business cycles and other macroeconomic confounding factors in the regression analysis and using the Australian federal government election as a parsimonious measure of EPU.
Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin
Creators: name: Gertler, A.
name: Kabanov, A.V.
name: Yi, X.
name: Vinogradov, S.
name: Solomon, G.
name: Batrakova, E.
name: Niv-Spector, L.
name: Banks, W.A.
name: Shpilman, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The blood-brain barrier (BBB) presents a tremendous challenge for the delivery of drugs to the central nervous system (CNS). This includes drugs that target brain receptors for the treatment of obesity and anorexia. Strategic drug delivery to brain (SDDB) is an approach that considers in depth the relations among the BBB, the candidate therapeutic, the CNS target, and the disease state to be treated. Here, we illustrate principles of SDDB with two different approaches to developing drugs based on leptin. In normal body weight humans and in non-obese rodents, leptin is readily transported across the BBB and into the CNS where it inhibits feeding and enhances thermogenesis. However, in obesity, the transport of leptin across the BBB is impaired, resulting in a resistance to leptin. As a result, it is difficult to treat obesity with leptin or its analogs that depend on the leptin transporter for access to the CNS. To treat obesity, we developed a leptin agonist modified by the addition of pluronic block copolymers (P85-leptin). P85-leptin retains biological activity and is capable of crossing the BBB by a mechanism that is not dependent on the leptin transporter. As such, P85-leptin is able to cross the BBB of obese mice at a rate similar to that of native leptin in lean mice. To treat anorexia, we developed a leptin antagonist modified by pegylation (PEG-MLA) that acts primarily by blocking the BBB transporter for endogenous, circulating leptin. This prevents blood-borne, endogenous leptin from entering the CNS, essentially mimicking the leptin resistance seen in obesity, and resulting in a significant increase in adiposity. These examples illustrate two strategies in which an understanding of the interactions among the BBB, CNS targets, and candidate therapeutics under physiologic and diseased conditions can be used to develop drugs effective for the treatment of brain disease.
Wikidata Notes for Bat Collectors
Creators: name: Leachman, Siobhan
Publisher: name: Zenodo
Year: 2020
Subjects: Bionomia
Wikidata
Biodiversity data
Specimen collector

description: The document summarises a presentation given to participants at a workshop on bat biodiversity data. It takes readers through the process of logging into Wikidata, how to create a new item for a scientific collector, how to add appropriately referenced statements to that Wikidata item including statements concerning unique identifiers relating to the scientific collector. It suggests an ontology for scientific collector Wikidata items, illustrates how to add the scientific collector Wikidata item to Bionomia.net and then gives practical examples upon which to use this workflow. The document goes on to give examples of Wikidata queries that can be undertaken once the appropriate data is added to Wikidata as well as showcase the Scholia profile tool. The presentation covered by this document was recorded in a YouTube video: https://www.youtube.com/watch?v=BYvoXKBSGA8 This presentation came from a workshop as part of a NSF Grant "Rapid Creation of a Data Product for the World's Specimens of Horseshoe Bats and Relatives, a Known Reservoir for Coronaviruses" and work from this grant is in Zenodo at https://doi.org/10.5281/zenodo.4416152 © Siobhan Leachman, 2020. Unless indicated otherwise for specific images, this document is licensed for re-use under the CC0 1.0 Universal Public Domain Dedication licence. Please note that this licence does not apply to any of the images. In essence, you are free to copy, modify, and distribute this document, even for commercial purposes without asking permission, as long as you abide by the other licence terms.
Wikidata Notes for Bat Collectors
Creators: name: Leachman, Siobhan
Publisher: name: Zenodo
Year: 2022
Subjects: Bionomia
Wikidata
Biodiversity data
Specimen collector

description: This is an updated version of this document. There has been a new Wikidata property created P11146 collection items at that required the "Structure of a Wikidata item for scientific collectors" section to be amended and updated. The document summarises a presentation given to participants at a workshop on bat biodiversity data. It takes readers through the process of logging into Wikidata, how to create a new item for a scientific collector, how to add appropriately referenced statements to that Wikidata item including statements concerning unique identifiers relating to the scientific collector. It suggests an ontology for scientific collector Wikidata items, illustrates how to add the scientific collector Wikidata item to Bionomia.net and then gives practical examples upon which to use this workflow. The document goes on to give examples of Wikidata queries that can be undertaken once the appropriate data is added to Wikidata as well as showcase the Scholia profile tool. The presentation covered by this document was recorded in a YouTube video: https://www.youtube.com/watch?v=BYvoXKBSGA8 This presentation came from a workshop as part of a NSF Grant "Rapid Creation of a Data Product for the World's Specimens of Horseshoe Bats and Relatives, a Known Reservoir for Coronaviruses" and work from this grant is in Zenodo at https://doi.org/10.5281/zenodo.4416152 © Siobhan Leachman, 2020. Unless indicated otherwise for specific images, this document is licensed for re-use under the CC0 1.0 Universal Public Domain Dedication licence. Please note that this licence does not apply to any of the images. In essence, you are free to copy, modify, and distribute this document, even for commercial purposes without asking permission, as long as you abide by the other licence terms.
Double Higgs production at NNLO interfaced to parton showers in GENEVA
Creators: name: Alioli, Simone
name: Billis, Georgios
name: Broggio, Alessandro
name: Gavardi, Alessandro
name: Kallweit, Stefan
name: Lim, Matthew A.
name: Marinelli, Giulia
name: Nagar, Riccardo
name: Napoletano, Davide
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: parton: showers
higher-order: 2
Higgs particle: production
resummation
interface
quantum chromodynamics
momentum transfer
numerical calculations

description: In this work, we study the production of Higgs boson pairs at next-to-next-to-leading order in QCD matched to parton showers, using the Geneva framework and working in the heavy-top-limit approximation. This includes the resummation of large logarithms of the zero-jettiness $\mathcal{T}_0$ up to the next-to-next-to-next-to-leading-log accuracy. This process features an extremely large momentum transfer, which makes its study particularly relevant for matching schemes such as that employed in Geneva, where the resummation of a variable different from that used in the ordering of the parton shower is used. To further study this effect, we extend the original shower interface designed for \textsc{Pythia8} to include other parton showers, such as Dire and Sherpa.
The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase
Creators: name: Schultz, H.D.
name: Manickam, D.S.
name: Zucker, I.H.
name: Gao, L.
name: Batrakova, E.V.
name: Roat, J.W.
name: Yang, R.-F.
name: Zimmerman, M.C.
name: Yin, J.-X.
name: Rosenbaugh, E.G.
name: Bronich, T.K.
name: Kabanov, A.V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Adenoviral-mediated overexpression of the intracellular superoxide (O2·-) scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD) in the brain attenuates central angiotensin II (AngII)-induced cardiovascular responses. However, the therapeutic potential for adenoviral vectors is weakened by toxicity and the inability of adenoviral vectors to target the brain following peripheral administration. Therefore, we developed a non-viral delivery system in which CuZnSOD protein is electrostatically bound to a synthetic poly(ethyleneimine)-poly(ethyleneglycol) (PEI-PEG) polymer to form a polyion complex (CuZnSOD nanozyme). We hypothesized that PEI-PEG polymer increases transport of functional CuZnSOD to neurons, which inhibits AngII intra-neuronal signaling. The AngII-induced increase in O2·-, as measured by dihydroethidium fluorescence and electron paramagnetic resonance spectroscopy, was significantly inhibited in CuZnSOD nanozyme-treated neurons compared to free CuZnSOD- and non-treated neurons. CuZnSOD nanozyme also attenuated the AngII-induced inhibition of K+ current in neurons. Intracarotid injection of CuZnSOD nanozyme into rabbits significantly inhibited the pressor response of intracerebroventricular-delivered AngII; however, intracarotid injection of free CuZnSOD or PEI-PEG polymer alone failed to inhibit this response. Importantly, neither the PEI-PEG polymer alone nor the CuZnSOD nanozyme induced neuronal toxicity. These findings indicate that CuZnSOD nanozyme inhibits AngII intra-neuronal signaling in vitro and in vivo.
Macrophage delivery of therapeutic nanozymes in a murine model of Parkinsons disease
Creators: name: Gendelman, H.E.
name: Li, S.
name: Klyachko, N.L.
name: Boska, M.D.
name: Kabanov, A.V.
name: Brynskikh, A.M.
name: Mosley, R.L.
name: Batrakova, E.V.
name: Zhao, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Background: Parkinsons disease is a common progressive neurodegenerative disorder associated with profound nigrostriatal degeneration. Regrettably, no therapies are currently available that can attenuate disease progression. To this end, we developed a cell-based nanoformulation delivery system using the antioxidant enzyme catalase to attenuate neuroinflammatory processes linked to neuronal death. Methods: Nanoformulated catalase was obtained by coupling catalase to a synthetic polyelectrolyte of opposite charge, leading to the formation of a polyion complex micelle. The nanozyme was loaded into bone marrow macrophages and its transport to the substantia nigra pars compacta was evaluated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Results: Therapeutic efficacy of bone marrow macrophages loaded with nanozyme was confirmed by twofold reductions in microgliosis as measured by CD11b expression. A twofold increase in tyrosine hydroxylase-expressing dopaminergic neurons was detected in nanozyme-treated compared with untreated MPTP-intoxicated mice. Neuronal survival was confirmed by magnetic resonance spectroscopic imaging. Bone marrow macrophage-loaded catalase showed sustained release of the enzyme in plasma. Conclusion: These data support the importance of macrophage-based nanozyme carriage for Parkinsons disease therapies.
Additional file 1 of Caregiver perceptions of in-home COVID-19 testing for children with medical complexity: a qualitative study
Creators: name: Jolliff, Anna
name: Werner, Nicole E.
name: Barton, Hanna J.
name: Howell, Kristina Devi
name: Kelly, Michelle M.
name: Morgen, Makenzie
name: Ehlenbach, Mary
name: Warner, Gemma
name: Katz, Barbara
name: Kieren, Madeline
name: DeMuri, Gregory
name: Coller, Ryan J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1. Semi-Structured Interview Guide.
Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs
Creators: name: Roques, C.
name: Li, S.
name: Batrakova, E.V.
name: Kabanov, A.V.
name: Bronich, T.K.
name: Schulz, A.
name: Jordan, R.
name: Luxenhofer, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Solubilization of highly hydrophobic drugs with carriers that are non-toxic, non-immunogenic and well-defined remains a major obstacle in pharmaceutical sciences. Well-defined amphiphilic di- and triblock copolymers based on poly(2-oxazolines) were prepared and used for the solubilization of Paclitaxel (PTX) and other water-insoluble drugs. Probing the polymer micelles in water with the fluorescence probe pyrene, an unusual high polar microenvironment of the probe was observed. This coincides with an extraordinary large loading capacity for PTX of 45. wt.% active drug in the formulation as well as high water solubility of the resulting formulation. Physicochemical properties of the formulations, ease of preparation and stability upon lyophilization, low toxicity and immunogenicity suggest that poly(2-oxazoline)s are promising candidates for the delivery of highly challenging drugs. Furthermore, we demonstrate that PTX is fully active and provides superior tumor inhibition as compared to the commercial micellar formulation.
Sensitive to a T: testing two types of computer-aided detection and two user response types in a visual search task
Creators: name: Cogle, Blake
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Spatial computer-aided detection (CAD) systems help radiologists detect tumours by marking suspicious regions in mammography images. When CAD cues are correct, observers find more tumours than when searching without CAD. However, when CAD cues are absent or incorrect, observers miss more tumours than without CAD. Kunar et al. (2017) suggest this is due to relying too much on CAD cues (the overreliance hypothesis). In addition to an overreliance on the information that CAD cues provide, attentional capture by CAD cues may aid or impair the observer. We conducted three visual search experiments where participants searched for a T among Ls embedded in noise to simulate mammography images. The first two experiments tested non-spatial CAD cues (removing attentional capture), with participants making present/absent (Experiment 1) or localisation (Experiment 2) responses. CAD increased overall performance only for present/absent responses. Experiment 3 used spatial CAD cues to compare the impact of response type (present/absent vs localisation). Miss rates were higher in the Present/Absent than the Localisation condition, suggesting this type of response encourages a less complete search than localisation. As radiologists use localisation, we suggest future research on medical imaging and CAD do the same. Changes in miss rates (compared to No CAD) in Experiment 2 demonstrate that observers are influenced by the information provided by CAD systems. A comparison of Experiments 2 and 3 suggests that attentional capture contributes to increasing overall performance. Thus, both information content and attentional capture by CAD appear to be responsible for altering observer behaviour. However, (relative to No CAD trials) lower false alarm and higher miss rates on trials where the CAD marks a distractor and fails to mark the target, suggest that attentional capture, rather than overreliance on the CAD cues, is responsible for miss errors on trials with incorrect CAD cues.
Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis
Creators: name: Kabanov, A.V.
name: Spitzenberger, T.J.
name: Persidsky, Y.
name: Diekmann, C.
name: Batrakova, E.V.
name: Gendelman, H.E.
name: Heilman, D.
name: Elmquist, W.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Most potent antiretroviral drugs (e.g., HIV-1 protease inhibitors) poorly penetrate the blood-brain barrier. Brain distribution can be limited by the efflux transporter, P-glycoprotein (P-gp). The ability of a novel drug delivery system (block co-polymer P85) that inhibits P-gp, to increase the efficacy of antiretroviral drugs in brain was examined using a severe combined immunodeficiency (SCID) mouse model of HIV-1 encephalitis (HIVE). Severe combined immunodeficiency mice inoculated with HIV-1 infected human monocyte-derived macrophages (MDM) into the basal ganglia were treated with P85, antiretroviral therapy (ART) (zidovudine, lamivudine and nelfinavir (NEL)), or P85 and ART. Mice were killed on days 7 and 14, and brains were evaluated for levels of viral infection. Antiviral effects of NEL, P85, or their combination were evaluated in vitro using HIV-1 infected MDM and showed antiretroviral effects of P85 alone. In SCID mice injected with virus-infected MDM, the combination of ART-P85 and ART alone showed a significant decrease of HIV-1 p24 expressing MDM (25% and 33% of controls, respectively) at day 7 while P85 alone group was not different from control. At day 14, all treatment groups showed a significant decrease in percentage of HIV-1 infected MDM as compared with control. P85 alone and combined ART-P85 groups showed the most significant reduction in percentage of HIV-1 p24 expressing MDM (8% to 22% of control) that were superior to the ART alone group (38% of control). Our findings indicate major antiretroviral effects of P85 and enhanced in vivo efficacy of antiretroviral drugs when combined with P85 in a SCID mouse model of HIVE.
New technologies for drug delivery across the blood brain barrier
Creators: name: Batrakova, E.V.
name: Kabanov, A.V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the brain from the periphery. Therefore, discovery of new modalities allowing for effective delivery of drugs and biomacromolecules to the central nervous system (CNS) is of great need and importance for treatment of neurodegenerative disorders. This manuscript focuses on three relatively new strategies. The first strategy involves inhibition of the drug efflux transporters expressed in BBB by Pluronic® block copolymers, which allows for the increased transport of the substrates of these transporters to the brain. The second strategy involves the design of nanoparticles conjugated with specific ligands that can target receptors in the brain microvasculature and carry the drugs to the brain through the receptor mediated transcytosis. The third strategy involves artificial hydrophobization of peptides and proteins that facilitates the delivery of these peptides and proteins across BBB. This review discusses the current state, advantages and limitations of each of the three technologies and outlines their future prospects.
[Curriculum di Carolina Franceschinis Valvassori]
Creators: name: Franceschinis Valvassori, Carolina
Publisher: name: Zenodo
Year: 2023
Subjects: Accademia dei Georgofili
Franceschinis Valvassori, Carolina
Curriculum vitae
1944
Donne
Scienziate
Pregiudizi

description: Manoscritto di Carolina Franceschinis Valvassori del 16 novembre 1944. Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili. Sezione contemporanea, E.b.7. Natura: manoscritto. Consistenza: c. 1
description: Digitalizzato come parte della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). https://www.georgofili.it/contenuti/riconoscere-il-merito-superare-i-pregiudizi-scienziate-ai-georgofili-1753-1911-mostra-in-rete/11369
Additional file 2 of Caregiver perceptions of in-home COVID-19 testing for children with medical complexity: a qualitative study
Creators: name: Jolliff, Anna
name: Werner, Nicole E.
name: Barton, Hanna J.
name: Howell, Kristina Devi
name: Kelly, Michelle M.
name: Morgen, Makenzie
name: Ehlenbach, Mary
name: Warner, Gemma
name: Katz, Barbara
name: Kieren, Madeline
name: DeMuri, Gregory
name: Coller, Ryan J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 2. COREQ (COnsolidated criteria for REporting Qualitative research) Checklist.
Euclidean Dynamical Triangulation revisited: is the phase transition really 1st order? (extended version)
Creators: name: Rindlisbacher, Tobias
name: de Forcrand, Philippe
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The transition between the two phases of 4D Euclidean Dynamical Triangulation [1] was long believed to be of second order until in 1996 first order behavior was found for sufficiently large systems [5,9]. However, one may wonder if this finding was affected by the numerical methods used: to control volume fluctuations, in both studies [5,9] an artificial harmonic potential was added to the action; in [9] measurements were taken after a fixed number of accepted instead of attempted moves which introduces an additional error. Finally the simulations suffer from strong critical slowing down which may have been underestimated. In the present work, we address the above weaknesses: we allow the volume to fluctuate freely within a fixed interval; we take measurements after a fixed number of attempted moves; and we overcome critical slowing down by using an optimized parallel tempering algorithm [12]. With these improved methods, on systems of size up to 64k 4-simplices, we confirm that the phase transition is first order. In addition, we discuss a local criterion to decide whether parts of a triangulation are in the elongated or crumpled state and describe a new correspondence between EDT and the balls in boxes model. The latter gives rise to a modified partition function with an additional, third coupling. Finally, we propose and motivate a class of modified path-integral measures that might remove the metastability of the Markov chain and turn the phase transition into second order.
description: 26 pages, 21 figures, extended version of arXiv:1311.4712
Tell me what you want: Internships and the demands of the local AEC industry in Brazil
Creators: name: Cuperschmid, Ana Regina
name: Melachos, Felipe Corres
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 390113
subject: Science, technology and engineering curriculum and pedagogy

description: Higher Education courses in Architecture and Urban Design in Brazil are structured by the National Curriculum Guidelines (DCN), which guide the formation of upcoming professionals by means of its Nucleus of Professional Knowledge. Internships offer an important opportunity to mold such young professionals, but reveal a partial compatibility between the local Architecture, Engineering and Construction (AEC) industry and the DCN. Thus, the objective of this research is to verify eventual adherences amongst the demands of the local AEC industry and the DCN’s Nucleus of Professional Knowledge. Such analysis was conducted by means of the data collected by web-based forms from architecture and urban design students from School of Civil Engineering, Architecture and Urbanism at Unicamp during the years of 2021 and 2022. Results show that the Nucleus of Professional Knowledge in the DCN partially reflects the demands of the local AEC industry. This paper’s contributions align the major towards the industry’s necessities.
Supplementary data Surface and structure of phosphatidylcholine membranes reconstructed with CoFe2O4 nanoparticles
Creators: name: A., Anosov
name: Astanina, Polina
name: I., Proskuryakov
name: Koplak, Oksana
name: Morgunov, Roman
Publisher: name: figshare
Year: 2022
Subjects: subject: Applied Physics
subject: 29901 Biological Physics
subject: FOS: Biological sciences

description: Structural changes in phosphatidylcholine lipid membranes caused by introduction of insoluble CoFe2O4 nanoparticles (NPs) are analyzed.
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
Creators: name: D'Sa, Karishma
name: Choi, Minee L
name: Wagen, Aaron Z
name: Setó-Salvia, Núria
name: Kopach, Olga
name: Evans, James R
name: Rodrigues, Margarida
name: Lopez-Garcia, Patricia
name: Lachica, Joanne
name: Clarke, Benjamin E
name: Singh, Jaijeet
name: Ghareeb, Ali
name: Bayne, James
name: Grant-Peters, Melissa
name: Garcia-Ruiz, Sonia
name: Chen, Zhongbo
name: Rodriques, Samuel
name: Athauda, Dilan
name: Gustavsson, Emil K
name: Taliun, Sarah A Gagliano
name: Toomey, Christina
name: Reynolds, Regina H
name: Young, George
name: Strohbuecker, Stephanie
name: Warner, Thomas
name: Rusakov, Dmitri A
name: Patani, Rickie
name: Bryant, Clare
name: Klenerman, David A
name: Gandhi, Sonia
name: Ryten, Mina
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Stem Cells
subject: Stem Cells
classificationCode: Gene Expression
subject: Gene Expression
classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Microfabrication & Bioengineering
subject: Microfabrication & Bioengineering
classificationCode: Synthetic Biology
subject: Synthetic Biology
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Imaging
subject: Imaging

description: RNA editing is a posttranscriptional mechanism that targets changes in RNA transcripts to modulate innate immune responses. We report the role of astrocyte-specific, ADAR1-mediated RNA editing in neuroinflammation in Parkinson's disease (PD). We generated human induced pluripotent stem cell-derived astrocytes, neurons and cocultures and exposed them to small soluble alpha-synuclein aggregates. Oligomeric alpha-synuclein triggered an inflammatory glial state associated with Toll-like receptor activation, viral responses, and cytokine secretion. This reactive state resulted in loss of neurosupportive functions and the induction of neuronal toxicity. Notably, interferon response pathways were activated leading to up-regulation and isoform switching of the RNA deaminase enzyme, ADAR1. ADAR1 mediates A-to-I RNA editing, and increases in RNA editing were observed in inflammatory pathways in cells, as well as in postmortem human PD brain. Aberrant, or dysregulated, ADAR1 responses and RNA editing may lead to sustained inflammatory reactive states in astrocytes triggered by alpha-synuclein aggregation, and this may drive the neuroinflammatory cascade in Parkinson's.
Effect of pluronic P85 on ATPase activity of drug efflux transporters
Creators: name: Batrakova, E.V.
name: Alakhov, V.Y.
name: Li, S.
name: Kabanov, A.V.
name: Li, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Purpose. Pluronic block copolymers are potent sensitizers of multidrug resistant (MDR) cancer cells. The sensitization effect by Pluronics is a result of two processes acting in concert: i) intracellular ATP depletion, and ii) inhibition of ATPase activity of drug efflux proteins. This work characterizes effects of Pluronic P85 on ATPase activities of Pgp, MRP1, and MRP2 drug efflux transport proteins and interaction of these proteins with their substrates, vinblastine, and leucotriene C4. Methods. Using membranes overexpressing Pgp, MRP1, and MRP2, the current study evaluates effects of Pluronic P85 (P85) on the kinetic parameters (V max, K m, V max/K m) of ATP hydrolysis by these ATPases. Results. The decreases in the maximal reaction rates (V max) and increases in apparent Michaelis constants (K m) for these transporters in the presence of various concentrations of P85 were observed. The mechanism of these effects may involve i) conformational changes of the transporter due to membrane fluidization and/or ii) nonspecific steric hindrance of the drug-binding sites by P85 chains embedded into cellular membranes. The extent of these alterations was increased in the row MRP1 < MRP2 ≪ Pgp. Conclusions. These data suggest that there are unifying pathways for the inhibition of Pgp and MRPs by the block copolymer. However, the effect of P85 on Pgp ATPase activity is considerably greater compared with the effects on MRP1 and MRP2 ATPases. This may be a reason for greater inhibitory effects of Pluronic in Pgp-compared with MRP-overexpressing cells.
Sensitization of Cells Overexpressing Multidrug-Resistant Proteins by Pluronic P85
Creators: name: Li, S.
name: Miller, D.W.
name: Batrakova, E.V.
name: Alakhov, V.Y.
name: Kabanov, A.V.
name: Elmquist, W.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Purpose. This study evaluated the chemosensitizing effects of Pluronic P85 (P85) on cells expressing multidrug resistance-associated proteins, MRP1 and MRP2. Methods. Cell models included MRP1- and MRP2-transfected MDCKII cells as well as doxorubicin-selected COR-L23/R cells overexpressing MRP1. Effects of P85 on cellular accumulation and cytotoxicity of vinblastine and doxorubicin were determined. Mechanistic studies characterized the effects of P85 on ATP and reduced glutathione (GSH) intracellular levels as well as MRP ATPase and glutathione-S-transferase (GST) activities in these cells. Results. Considerable increases of vinblastine and doxorubicin accumulation in the cells overexpressing MRP1 and MRP2 in the presence of P85 were observed, although no statistically significant changes in drug accumulation in the parental cells were found. P85 treatment caused an inhibition of MRP ATPase activity. Furthermore, P85 induced ATP depletion in these cells similar to that previously reported for Pgp-overexpressing cells. In addition, reduction of GSH intracellular levels and decrease of GST activity were observed following P85 treatment. Finally, significant enhancement of cytotoxicity of vinblastine and doxorubicin by P85 in MRP-overexpressing cells was demonstrated. Conclusions. This study suggests that P85 can sensitize cells overexpressing MRP1 and MRP2, which could be useful for chemotherapy of cancers that display these resistant mechanisms.
IMPACT OF URINARY SYSTEM INFECTION ON THE DEVELOPMENT OF THE RISK OF POST-TERM PREGNANCY
Creators: name: Ismoilova, Mavlyuda
Publisher: name: Zenodo
Year: 2024

description: The article presents the results of studying the risk factors for urinary tract infection and its impact on the development of preterm labor. A To solve prospective analysis was carried out. the tasks set in the work, 128 women (Group I - 65 women with UTIs and the threat of PR and II 63 women with PR group without infections) and 25 women in the control group were conditionally healthy pregnant women who underwent enzyme-linked immunosorbent assay (ELISA), metalloproteinase level 12 (ADAM 12), cystatin C, RBP4 in blood serum. In the venous blood, the indicators of the hemostasis system were studied, the microbiocenoses of the vagina and the general analysis of urine in women with a threat were studied.
Additional file 1 of Variation in morpho-physiological and metabolic responses to low nitrogen stress across the sorghum association panel
Creators: name: Grzybowski, Marcin W.
name: Zwiener, Mackenzie
name: Jin, Hongyu
name: Wijewardane, Nuwan K.
name: Atefi, Abbas
name: Naldrett, Michael J.
name: Alvarez, Sophie
name: Ge, Yufeng
name: Schnable, James C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary file 1: Table S3. and Figures S1-10.
Prefigurative Information Politics: Strategies for Survival, Resilience, and Liberation
Creators: name: Threats, Megan
name: Gibson, Amelia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Invited lecture as part of the Srygley Lecture series at Florida State University, presented February 24, 2021. Description of model in progress, coauthored with Megan Threats.
An epidemiological profile of women suffering from urinary incontinence residing at one of the cities of western India: A mixed method approach study
Creators: name: Sharma, Karan
name: Khandhedia, Parth
name: Dave, Viral
Publisher: name: Journal of Preventive Medicine and Hygiene
Year: 2023
Subjects: Urinary incontinence
ICIQ
Treatment seeking behavior
quality of life
Community Medicine
Public health

description: Introduction: Urinary incontinence (UI), a discomforting condition is predominantly seen in women. Affected women must modify their lifestyles to alleviate symptoms and associated complications. Objectives: To find the prevalence, determinants, and association of UI with Socio-demographic, obstetrical, gynecological, and personal history and its impact on quality of life. Methods: Research was conducted with a mixed method approach (quantitative and qualitative assessment) among women residing in urban slum of Ahmedabad city, India. Sample size calculated was 457. The study was conducted in urban slums served by one of the Urban Health Centres (UHC) of Ahmedabad city. A modified pre-evaluated standard questionnaire developed by International Consultation on Incontinence Questionnaire (ICIQ) was used for quantitative part. Qualitative part consisted of Focused Group Discussions (FGD) which was carried out amongst the women in batches of 5-7 per discussion. Results: Prevalence of UI was found to be 30% among study participants. A statistically significant relation was seen between the presence of UI and Age, Marital Status, Parity, past history of abortion, and occurrence of Urinary Tract Infection(UTI) in the last year (P<0.05). Comparison of severity of UI by calculating ICIQ score showed statistically significant relation of same with Age, Occupation, Literacy, Socioeconomic status, and Parity (P<0.05). More than 50% of women suffering from UI were having chronic constipation, reduced daily sleep, and diabetes. Only 7% of the total women suffering from UI had consulted doctor for their problem. Conclusion: Prevalence of UI was found to be 30% in study participants. Sociodemographic factors like age, marital status, and socio-economic class were found to have statistically significant effects on existing UI at the time of interview. ICIQ categories of UI were found to be influenced statistically by age, occupation, literacy, socio-economic class parity and obstetric factors like place of delivery and facilitator of delivery. Most participants (93%) had never consulted a doctor for various reasons/myths like it shall resolve on its own, Belief that it is a normal age-related phenomenon, shyness to discuss issues with male doctors/members of family, and financial reasons.
description: Journal of Preventive Medicine and Hygiene, Vol. 63 No. 4 (2022): Vol. 63 No. 4 (2022)
Chimeras in globally coupled oscillatory systems: From ensembles of oscillators to spatially continuous media
Creators: name: Schmidt, Lennart
name: Krischer, Katharina
Publisher: name: arXiv
Year: 2015
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study an oscillatory medium with a nonlinear global coupling that gives rise to a harmonic mean-field oscillation with constant amplitude and frequency. Two types of cluster states are found, each undergoing a symmetry-breaking transition towards a related chimera state. We demonstrate that the diffusional coupling is non-essential for these complex dynamics. Furthermore, we investigate localized turbulence and discuss whether it can be categorized as a chimera state.
Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer
Creators: name: Karuturi, M.S.
name: Jolly, T.A.
name: Reeve, B.B.
name: Reeder-Hayes, K.E.
name: Kimmick, G.G.
name: Carey, L.A.
name: Reinbolt, R.E.
name: Wood, W.A.
name: Shachar, S.S.
name: Dees, E.C.
name: Deal, A.M.
name: Nyrop, K.A.
name: Brenizer, A.
name: Chen, Y.T.
name: Speca, J.C.
name: Basch, E.M.
name: Muss, H.B.
name: Lee, J.T.
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: Background: To the authors' knowledge, it is unknown whether patient-reported symptom severity and symptom interference with daily activities differ between younger (aged <65 years) and older (aged ≥65 years) women receiving similar chemotherapy regimens for early breast cancer (EBC). Methods: Study participants rated 17 side effects of chemotherapy regimens currently in use in clinical practice (2014-2019). Results: Of 284 women with EBC (stage I-III), approximately 57% were aged <65 years and 43% were aged ≥65 years. For anthracycline-based regimens, a higher percentage of younger women reported moderate, severe, or very severe (MSVS) hot flashes (49% vs 18%) (P <.001). For nonanthracycline regimens, a higher percentage of younger women reported MSVS hot flashes (38% vs 19%) (P =.009) and a lower percentage reported MSVS arthralgia (28% vs 49%) (P =.005). With regard to symptom interference with daily activities, a higher percentage of younger women being treated with anthracycline-based regimens reported MSVS hot flashes (32% vs 7%) (P =.001) and myalgia (38% vs 18%) (P =.02). For nonanthracycline chemotherapy, a higher percentage of younger women reported MSVS interference for hot flashes (26% vs 9%) (P =.006) and lower percentages reported abdominal pain (13% vs 28%) (P =.02). Overall, there were no significant differences noted among younger versus older patients with regard to hospitalizations (19% vs 12%; P =.19), dose reductions (34% vs 31%; P =.50), dose delays (22% vs 25%; P =.59), or early treatment discontinuation (16% vs 16%; P =.9546). Conclusions: Older and younger women with EBC who were treated with identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom-related interference with daily activities, and adverse events. Lay Summary: In this study, women receiving chemotherapy for early breast cancer rated the severity of 17 symptoms and symptom interference with their activities of daily living. Older (aged ≥65 years) and younger (aged <65 years) women who received identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom-related interference with daily activities, and adverse events.
Aerodynamic investigation of guide vane configurations downstream a rotating detonation combustor
Creators: name: Asli, Majid
name: Stathopoulos, Panagiotis
name: Paschereit, Christian Oliver
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: blades
subject: chords
subject: combustion chambers
subject: damping
subject: exhaust systems
subject: explosions
subject: flow
subject: guide vanes
subject: pressure
subject: combustion

description: Any outlet restriction downstream of pressure gain combustion (PGC), such as turbine blades, affects its flow field and may cause additional thermodynamic losses. The unsteadiness in the form of pressure, temperature, and velocity vector fluctuations has a negative impact on the operation of conventional turbines. Additionally, experimental measurements and data acquisition present researchers with challenges that have to do mostly with the high temperature exhaust of PGC and the high frequency of its operation. Nevertheless, numerical simulations can provide important insights into PGC exhaust flow and its interaction with turbine blades. In this paper, a rotating detonation combustor (RDC) and a row of nozzle guide vanes have been modeled based on the data from literature and an available experimental setup. Unsteady Reynolds-averaged Navier–Stokes (URANS) simulations were done for five guide vane configurations with different geometrical parameters to investigate the effect of solidity and blade type representing different outlet restrictions on the RDC exhaust flow. The results analyzed the connection between total pressure loss and the vanes solidity and thickness to chord ratio. It is observed that more than 57% of the upstream velocity angle fluctuation amplitude was damped by the vanes. Furthermore, the area reduction was found to be the significant driving factor for damping the velocity angle fluctuations, whether in the form of solidity or thickness on chord ratio increment. This RDC exhaust flow investigation is an important primary step from a turbomachinery standpoint, which provided details of blade behavior in such an unsteady flow field.