cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dual Band Octagonal Microstrip Patch Antenna Design Method for Energy Harvesting
Creators: name: Rivera-Abreu, Francisco
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Electrical engineering not elsewhere classified

description: A practical method to design dual-band octagonal patch antenna is introduced. The antenna consists of an octagonal patch with a proximity coupling feed designed to radiate at 900 MHz and 1.8 GHz, respectively. The octagonal dual band patch antenna that is designed using the method introduced is then simulated with 3D FEM based electromagnetic simulator. The proposed antenna design can be used to harvest radio frequency (RF) energy from Wi-Fi and widely spread mobile networks. The simulated and analytical results are compared and good agreement is observed.
Additional file 1 of Benefits of near-universal vaccination and treatment access to manage COVID-19 burden in the United States
Creators: name: Yang, Fuhan
name: Tran, Thu Nguyen-Anh
name: Howerton, Emily
name: Boni, Maciej F.
name: Servadio, Joseph L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Text S1. Estimating current and future vaccine coverages. Table S1. Estimated durations of immunity following vaccination or infection from literature. Table S2. Updated clinical parameters for the Omicron variant. Table S3. COVID-19 vaccine doses administered by age group in the United States between December 1, 2021-November 30, 2022. Table S4. Treatment efficacies of COVID-19 therapeutics. Figure S1. Model diagram. Figure S2. Calibrated output compared to observed data in RI and the US. Figure S3. Cumulative doses of COVID-19 vaccines administered in the United States. Figure S4. Coverage of Paxlovid in 50 states as of Dec 11, 2022. Figure S5. Vaccination coverage in 50 states between Dec 1, 2021, and Nov 30, 2022. Figure S6. Weekly percentages of achieved coverage of influenza vaccination by age groups by calendar month. Figure S7. Burden reduction slopes following treatment coverage under different vaccination coverages. Figure S8. Heatmaps of annual mortality under combinations of vaccine and treatment coverage under each transmission scenario and rate of immune waning. Figure S9. Heatmaps of annual hospitalizations under combinations of vaccine and treatment coverage under each transmission scenario and rate of immune waning. Figure S10. Heatmaps of annual incident cases under combinations of vaccine and treatment coverage under each transmission scenario and rate of immune waning. Figure S11. Combinations of treatment coverage and vaccine coverage that lead to COVID-19 mortality within the range of annual influenza mortality as well as below or over this range. Figure S12. Annual burden between 2025 and 2033 given 50% and 88% vaccine effectiveness. Figure S13. Annual burden between 2025 and 2033 given 20% probability of treatment failure. Figure S14. Annual burden between 2025 and 2033 given 30% and 50% risk reduction to hospitalization after failed treatment.
Information Labour and Shame in Farmer and Chevli’s Abortion Eve
Creators: name: Eve, Martin Paul
name: Melanie, McGovern
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Graphic novels

description: This article conducts the first in-depth political-aesthetic analysis of Joyce Farmer and Lyn Chevli’s Abortion Eve. In this article we argue that Abortion Eve uses its visual form in a way that cuts between the contexts of later forms of graphic medicine and feminist comix, and in so doing contributed to a political culture of feminist information sharing, through a self-published visual medium.
How long do nosocomial pathogens persist on inanimate surfaces? A systematic review
Creators: name: Kramer, Axel
name: Schwebke, Ingeborg
name: Kampf, Günter
Publisher: name: Robert Koch-Institut
Year: 2006
Subjects: subject: Humans
subject: Hospitals
subject: Virus Diseases/virology
subject: Bacterial Infections/microbiology
subject: Cross Infection/microbiology
subject: Cross Infection/virology
subject: Fomites/microbiology
subject: Fomites/virology
subject: Fungi/growth & development
subject: Gram-Negative Bacteria/growth & development
subject: Gram-Positive Bacteria/growth & development
subject: Mycoses/microbiology
subject: Viruses/growth & development
subject: 610 Medizin

description: Background: Inanimate surfaces have often been described as the source for outbreaks of nosocomial infections. The aim of this review is to summarize data on the persistence of different nosocomial pathogens on inanimate surfaces. Methods: The literature was systematically reviewed in MedLine without language restrictions. In addition, cited articles in a report were assessed and standard textbooks on the topic were reviewed. All reports with experimental evidence on the duration of persistence of a nosocomial pathogen on any type of surface were included. Results: Most gram-positive bacteria, such as Enterococcus spp. (including VRE), Staphylococcus aureus (including MRSA), or Streptococcus pyogenes, survive for months on dry surfaces. Many gramnegative species, such as Acinetobacter spp., Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, Serratia marcescens, or Shigella spp., can also survive for months. A few others, such as Bordetella pertussis, Haemophilus influenzae, Proteus vulgaris, or Vibrio cholerae, however, persist only for days. Mycobacteria, including Mycobacterium tuberculosis, and spore-forming bacteria, including Clostridium difficile, can also survive for months on surfaces. Candida albicans as the most important nosocomial fungal pathogen can survive up to 4 months on surfaces. Persistence of other yeasts, such as Torulopsis glabrata, was described to be similar (5 months) or shorter (Candida parapsilosis, 14 days). Most viruses from the respiratory tract, such as corona, coxsackie, influenza, SARS or rhino virus, can persist on surfaces for a few days. Viruses from the gastrointestinal tract, such as astrovirus, HAV, polio- or rota virus, persist for approximately 2 months. Blood-borne viruses, such as HBV or HIV, can persist for more than one week. Herpes viruses, such as CMV or HSV type 1 and 2, have been shown to persist from only a few hours up to 7 days. Conclusion: The most common nosocomial pathogens may well survive or persist on surfaces for months and can thereby be a continuous source of transmission if no regular preventive surface disinfection is performed.
In defense of the natural and indeclinable order of the market and law : how to avoid future global banking crises : a new supervisory parametric banking architecture in a cyberspace context based on the thesis of a ?hidden nexus? between contracts and the social contract and its limit in the neminem laedere principle (or the "theory of the gaming table?)
Creators: name: ROMANO, ROSITA
Publisher: name: Luiss Guido Carli
Year: 2020

description: The Premises. The importance of communication; the person as the architect of market; the unmodifiable order in Romagnosi?s point of view; the rule-makers ?syndrome of Laius?. The new thesis of the ?hidden nexus? between contracts and the Social Contract and its limitation in the ?neminem laedere? principle (or the ?theory of the gaming table?). The Origin of the Global Financial Crisis and the application of the thesis of the ?hidden nexus? between contracts and Social contract or "the gaming table theory?. Munch?s the Scream of regulation and reforms policy in the European Union and banking supervisory architecture. Designing a new Supervisory Parametric Banking Architecture in a cyberspace context.
The Role of the European Court of Justice in Framing the Principles of Global Distributive Justice through the Area of Asylum
Creators: name: KUCUKSU, AYSEL
Publisher: name: Luiss Guido Carli
Year: 2020

description: At the crossroads between political philosophy and law. Research interest and project relevance: the changing nature of forced migration and the rising number of asylum seekers. State of the art: global justice theories on migration and Martha Fineman?s ?vulnerability thesis?. The idiosyncrasies of the ECJ. The idiosyncrasies of the CEAS as a site of overlapping legalities. Empirical evidence of preoccupation with procedural justice at the ECJ. The ?vulnerability thesis?: bridging the gap between the disciplines of political philosophy and law.
CAN SIMULATION SOFTWARE INTEGRATED WITH GAMIFICATION ENHANCE STUDENTS’ UNDERSTANDING OF PROJECT EXECUTION CONCEPTS BY IMPROVING LEARNING OUTCOMES?
Creators: name: Debroy, Sreemoyi
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other engineering not elsewhere classified

description: This research study explores the gamification of SandBoxModel's Project Team Builder, a project management simulation software. Scope, time and cost are the three constraints of project management with quality being the fourth dimension. The software provides a simulated environment where the students are responsible for handling the aforementioned constraints with the objective of executing a complete project. The software is used to teach project management concepts to students who take the CNIT 480 - Managing Information Technology Projects course at Purdue University. The perception survey was used to analyze whether gamification had a significant effect on student understanding of project execution concepts. The triple constraint survey was used to analyze students' level of comprehension regarding the triple constraints after using the simulation software. Gamification was not a success in enhancing project execution concepts since no significant differences were found in student perceptions on comparing the data of the three semesters. However, simulation independent of gamification was successful in improving students' understanding of triple constraint.
A Novel Highly Reproducible and Lethal Nonhuman Primate Model for Orthopox Virus Infection
Creators: name: Kramski, Marit
name: Mätz-Rensing, Kerstin
name: Stahl-Hennig, Christiane
name: Kaup, Franz-Josef
name: Nitsche, Andreas
name: Pauli, Georg
name: Ellerbrok, Heinz
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2010
Subjects: subject: Animals
subject: Callithrix
subject: Cowpox virus
subject: Disease Models Animal
subject: Orthopoxvirus/pathogenicity
subject: Poxviridae Infections
subject: Smallpox Vaccine
subject: Survival Rate
subject: 610 Medizin

description: The intentional re-introduction of Variola virus (VARV), the agent of smallpox, into the human population is of great concern due its bio-terroristic potential. Moreover, zoonotic infections with Cowpox (CPXV) and Monkeypox virus (MPXV) cause severe diseases in humans. Smallpox vaccines presently available can have severe adverse effects that are no longer acceptable. The efficacy and safety of new vaccines and antiviral drugs for use in humans can only be demonstrated in animal models. The existing nonhuman primate models, using VARV and MPXV, need very high viral doses that have to be applied intravenously or intratracheally to induce a lethal infection in macaques. To overcome these drawbacks, the infectivity and pathogenicity of a particular CPXV was evaluated in the common marmoset (Callithrix jacchus). A CPXV named calpox virus was isolated from a lethal orthopox virus (OPV) outbreak in New World monkeys. We demonstrated that marmosets infected with calpox virus, not only via the intravenous but also the intranasal route, reproducibly develop symptoms resembling smallpox in humans. Infected animals died within 1–3 days after onset of symptoms, even when very low infectious viral doses of 56102 pfu were applied intranasally. Infectious virus was demonstrated in blood, saliva and all organs analyzed. We present the first characterization of a new OPV infection model inducing a disease in common marmosets comparable to smallpox in humans. Intranasal virus inoculation mimicking the natural route of smallpox infection led to reproducible infection. In vivo titration resulted in an MID50 (minimal monkey infectious dose 50%) of 8.36102 pfu of calpox virus which is approximately 10,000-fold lower than MPXV and VARV doses applied in the macaque models. Therefore, the calpox virus/marmoset model is a suitable nonhuman primate model for the validation of vaccines and antiviral drugs. Furthermore, this model can help study mechanisms of OPV pathogenesis.
Risk of transmitting meningococcal infection by transient contact on aircraft and other transport
Creators: name: Rachael, T.
name: Schubert, K.
name: Hellenbrand, Wiebke
name: Krause, Gérard
name: Stuart, J.M.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: Humans
subject: Travel
subject: Aircraft
subject: Contact Tracing
subject: Meningococcal Infections/transmission
subject: Risk
subject: 610 Medizin

description: Contact tracing of persons with meningococcal disease who have travelled on aeroplanes or other multi-passenger transport is not consistent between countries. We searched the literature for clusters of meningococcal disease linked by transient contact on the same plane, train, bus or boat. We found reports of two clusters in children on the same school bus and one in passengers on the same plane. Cases within each of these three clusters were due to strains that were genetically indistinguishable. In the aeroplane cluster the only link between the two cases was through a single travel episode. The onset of illness (2 and 5 days after the flight) is consistent with infection from an unidentified carrier around the time of air travel. In contrast to the established risk of transmission from a case of tuberculosis, it is likely that the risk from a case of meningococcal disease to someone who is not identified as a close contact is exceedingly low. This should be considered in making international recommendations for passenger contact tracing after a case of meningococcal disease on a plane or other multi-passenger transport.
Additional file 2 of Effect of COVID-19 on antenatal care: experiences of medical professionals in the Netherlands
Creators: name: Gamberini, Carlotta
name: Angeli, Federica
name: Knight, Lucia
name: Zaami, Mariama
name: Al-Nasiry, Salwan
name: Ambrosino, Elena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Interview guide for semi-structured interviews with healthcare professionals (midwives, gynaecologists). Interview guide that was developed with and reviewed by ANC experts, and was used to intervie3w participants.
Supplemental Material, sj-pdf-1-tct-10.1177_15330338211027898 - Controllable Drug Delivery by Na+/K+ ATPase α1 Targeting Peptide Conjugated DSPE-PEG Nanocarriers for Breast Cancer
Creators: name: Yang, Yayan
name: Feng, Qian
name: Ding, Chuanfeng
name: Kang, Wei
name: Xiao, Xiufeng
name: Yu, Yongsheng
name: Zhou, Qian
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified
Radiology and Organ Imaging
Biochemistry

description: Supplemental Material, sj-pdf-1-tct-10.1177_15330338211027898 for Controllable Drug Delivery by Na+/K+ ATPase α1 Targeting Peptide Conjugated DSPE-PEG Nanocarriers for Breast Cancer by Yayan Yang, Qian Feng, Chuanfeng Ding, Wei Kang, Xiufeng Xiao, Yongsheng Yu and Qian Zhou in Technology in Cancer Research & Treatment
164. Sub-subgiants and (tiny) black holes
Creators: name: Perryman, Michael
Publisher: name: Zenodo
Year: 2024
Subjects: Gaia

description: I look at some recent advances in the numbers of blue stragglers identified by Gaia, and Gaia's contribution to the identification and understanding of the new class of sub-subgiant star. I discuss whether these offer a particularly interesting search sample for stars hosting primordial black holes in their centres.
"Re-Envisioning Japan"  DH project overview - MLA2020 Collaborative Round Table (DH in Japan & Korea Studies: Approaches and Challenges)
Creators: name: Bernardi, Joanne
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Digital humanities
subject: Japanese--Social life and customs
subject: Digital preservation
subject: Material culture
subject: Japan
subject: East Asia
subject: Area studies
subject: Motion pictures

description: Powerpoint presentation for the MLA2020 collaborative roundtable "Digital Humanities in Japan and Korea: Approaches and Challenges," organized by the LLC Korean and LLC Japanese since 1900 Forums.  This brief introduction to "Re-Envisioning Japan: Japan as Destination in 20th Century Visual and Material Culture" was one of seven presentations by East Asian scholars working on Korea- and Japan-related DH projects, each targeting specific challenges to digital scholarship and pedagogy in these two fields.  "Re-Envisioning Japan" is an open-ended DH project comprising a multimodal digital archive and a heterogeneous physical collection of Japan-related travel, education, and entertainment ephemera; it has a dedicated companion course, "Tourist Japan," a hands-on digital humanities lab course in which students complete assignments (e.g., "Object Encounters," slide 5) that bridge academic inquiry and curatorial skills. After a brief introduction of "Re-Envisioning Japan" (slides 1-3), I introduced three topics for discussion (summarized on slide 4) based on my experience in Japan-specific DH scholarship and pedagogy: (1) evaluation of digital scholarship in tenure and promotion, (2) sustainability and support for Japan-specific DH projects, and (3) rewards.
Nosocomial Transmission of Hepatitis C Virus Associated With the Use of Multidose Saline Vials
Creators: name: Krause, Gérard
name: Trepka, Mary Jo
name: Whisenhunt, Robert S.
name: Katz, Dolly
name: Nainan, Omana
name: Wiersma, Steven T.
name: Hopkins, Richard S.
Publisher: name: Robert Koch-Institut
Year: 2003
Subjects: subject: Adolescent
subject: Humans
subject: Female
subject: Genotype
subject: Disease Outbreaks
subject: Male
subject: Middle Aged
subject: RNA
subject: Child
subject: Viral/analysis
subject: Adult
subject: Cohort Studies
subject: Aged
subject: Retrospective Studies
subject: Cross Infection/virology
subject: Blood-Borne Pathogens
subject: Catheters
subject: Indwelling/virology
subject: Cross Infection/epidemiology
subject: Cross Infection/etiology
subject: Equipment Contamination
subject: Florida
subject: Hepacivirus/genetics
subject: Hepacivirus/isolation & purification
subject: Hepatitis C/diagnosis
subject: Hepatitis C/epidemiology
subject: Hepatitis C/etiology
subject: Hepatitis C Antibodies/blood
subject: Hospital Units/statistics & numerical data
subject: Reverse Transcriptase Polymerase Chain Reaction
subject: Sodium Chloride
subject: Syringes/virology
subject: Aged 80 and over
subject: 610 Medizin

description: Objective: To identify the source of an outbreak of acute hepatitis C virus (HCV) infection among 3 patients occurring within 8 weeks of hospitalization in the same ward of a Florida hospital during November 1998. Design: A retrospective cohort study was conducted among 41 patients hospitalized between November 11 and 19, 1998. Patients' blood was tested for antibodies to HCV, and HCV RNA-positive samples were genotyped and sequenced. Results: Of the 41 patients, 24 (59%) participated in the study. HCV genotype lb infections were found in 5 patients. Three of 4 patients who received saline flushes from a multidose saline vial on November 16 had acute HCV infection, whereas none of the 9 patients who did not receive saline flushes had HCV infection (P = .01). No other significant exposures were identified. The HCV sequence was available for 1 case of acute HCV and differed by a single nucleotide (0.3%) from that of the indeterminate case. Conclusion: This outbreak of HCV probably occurred when a multidose saline vial was contaminated with blood from an HCV-infected patient Hospitals should emphasize adherence to standard procedures to prevent blood-borne infections. In addition, the use of single-dose vials or prefilled saline syringes might further reduce the risk for nosocomial transmission of blood-borne pathogens.
Using Latent Discourse Indicators to identify goodness in online conversations
Creators: name: Jain, Ayush
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Applied computing not elsewhere classified
Knowledge representation and reasoning
Natural language processing

description: In this work, we model latent discourse indicators to classify constructive and collaborative conversations online. Such conversations are considered good as they are rich in content and have a sense of direction to resolve an issue, solve a problem or gain new insights and knowledge. These unique discourse indicators are able to characterize flow of information, sentiment and community structure within discussions. We build a deep relational model that captures these complex discourse behaviors as latent variables and make a global prediction about overall conversation based on these higher level discourse behaviors. DRaiL, a Declarative Deep Relational Learning platform built on PyTorch, is used for our task in which relevant discourse behaviors are formulated as discrete latent variables and scored using a deep model. These variables capture the nuances involved in online conversations and provide the information needed for predicting the presence or absence of collaborative and constructive characterization in the entire conversational thread. We show that the joint modeling of such competing latent behaviors results in a performance improvement over the traditional direct classification methods in which all the raw features are just combined together to predict the final decision. The Yahoo News Annotated Comments Corpus is used as a dataset containing discussions on Yahoo news forums and final labels are annotated based on our precise and restricted definitions of positively labeled conversations. We formulated our annotation guidelines based on a sample set of conversations and resolved any conflict in specific annotation by revisiting those examples again.
The Genome of a Bacillus Isolate Causing Anthrax in Chimpanzees Combines Chromosomal Properties of B. cereus with B. anthracis Virulence Plasmids
Creators: name: Klee, Silke
name: Brzuszkiewicz, Elzbieta B.
name: Nattermann, Herbert
name: Brüggemann, Holger
name: Dupke, Susann
name: Wollherr, Antje
name: Franz, Tatjana
name: Pauli, Georg
name: Appel, Bernd
name: Liebl, Wolfgang
name: Couacy-Hymann, Emmanuel
name: Boesch, Christophe
name: Meyer, Frauke-Dorothee
name: Leendertz, Fabian
name: Ellerbrok, Heinz
name: Gottschalk, Gerhard
name: Grunow, Roland
name: Liesegang, Heiko
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: Animals
subject: Bacterial/genetics
subject: Anthrax/microbiology
subject: Bacillus anthracis/genetics
subject: Pan troglodytes/microbiology
subject: Bacillus anthracis/pathogenicity
subject: Genome
subject: Anthrax/veterinary
subject: Bacillus cereus/genetics
subject: Chromosomes
subject: Computational Biology
subject: Models Genetic
subject: Plasmids/genetics
subject: Primate Diseases/microbiology
subject: Regulon/genetics
subject: Virulence/genetics
subject: 610 Medizin

description: Anthrax is a fatal disease caused by strains of Bacillus anthracis. Members of this monophyletic species are non motile and are all characterized by the presence of four prophages and a nonsense mutation in the plcR regulator gene. Here we report the complete genome sequence of a Bacillus strain isolated from a chimpanzee that had died with clinical symptoms of anthrax. Unlike classic B. anthracis, this strain was motile and lacked the four prohages and the nonsense mutation. Four replicons were identified, a chromosome and three plasmids. Comparative genome analysis revealed that the chromosome resembles those of non-B. anthracis members of the Bacillus cereus group, whereas two plasmids were identical to the anthrax virulence plasmids pXO1 and pXO2. The function of the newly discovered third plasmid with a length of 14 kbp is unknown. A detailed comparison of genomic loci encoding key features confirmed a higher similarity to B. thuringiensis serovar konkukian strain 97-27 and B. cereus E33L than to B. anthracis strains. For the first time we describe the sequence of an anthrax causing bacterium possessing both anthrax plasmids that apparently does not belong to the monophyletic group of all so far known B. anthracis strains and that differs in important diagnostic features. The data suggest that this bacterium has evolved from a B. cereus strain independently from the classic B. anthracis strains and established a B. anthracis lifestyle. Therefore we suggest to designate this isolate as ‘‘B. cereus variety (var.) anthracis’’.
"Re-Envisioning Japan" DH project overview - MLA2020 Collaborative Round Table (DH in Japan & Korea Studies: Approaches and Challenges)
Creators: name: Bernardi, Joanne
Publisher: name: unknown
Year: 2020
Subjects: subject: Motion pictures
subject: Japanese--Social life and customs
subject: Digital humanities
subject: Digital preservation
subject: East Asia
subject: Area studies
subject: Japan
subject: Material culture

description: Powerpoint presentation for the MLA2020 collaborative roundtable "Digital Humanities in Japan and Korea: Approaches and Challenges," organized by the LLC Korean and LLC Japanese since 1900 Forums. This brief introduction to "Re-Envisioning Japan: Japan as Destination in 20th Century Visual and Material Culture" was one of seven presentations by East Asian scholars working on Korea- and Japan-related DH projects, each targeting specific challenges to digital scholarship and pedagogy in these two fields. "Re-Envisioning Japan" is an open-ended DH project comprising a multimodal digital archive and a heterogeneous physical collection of Japan-related travel, education, and entertainment ephemera; it has a dedicated companion course, "Tourist Japan," a hands-on digital humanities lab course in which students complete assignments (e.g., "Object Encounters," slide 5) that bridge academic inquiry and curatorial skills. After a brief introduction of "Re-Envisioning Japan" (slides 1-3), I introduced three topics for discussion (summarized on slide 4) based on my experience in Japan-specific DH scholarship and pedagogy: (1) evaluation of digital scholarship in tenure and promotion, (2) sustainability and support for Japan-specific DH projects, and (3) rewards.
Using the Collective System Design Approach to Facilitate a Sustainable Manufacturing System
Creators: name: Shah, Shahab
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other engineering not elsewhere classified

description: Reviewing the literature verifies that manufacturing industries fall short of the required sustainable criteria in the system design.One of the leading reasons behind such a failure refers to the lack of an effective system design's knowledge toward the selected solutions by benchmarking.The Collective System Design (CSD) approach provides a countermeasure for this shortcoming by starting the design approach with a collective agreement upon the external and internal customer needs and then choosing the solutions for the system design to achieve those needs. The general requirements and solutions to a manufacturing system are covered in the Manufacturing System Design Decomposition (MSDD) in a linear and path-dependent fashion, which is a core derivative of the CSD.
The CSD application in industrial case studies has been provided in this thesis to elaborate on how the CSD approach assists industries to re-design their systems in a sustainable manner.The segregation of the tools and objectives of the system re-design in a path-dependent fashion is guided by the design principles.The case studies described how to achieve the external customer needs of product quality, quantity, variety, and on-time delivery with a collaborative work inside the plant. This collaboration was built up by defining the customer-supplier connection inside the plant.Cell re-design and balancing of operations with a well-defined standard work is also elaborated in this research to help produce what is needed to be shipped today with the least amount of waste in the system.The after system redesign MSDD questionnaire analysis at these industries have shown that the industries successfully satisfied their system needs in a sustainable manner.
In those case studies, an internal customer need for a safe working environment was also brought to light and the CSD approach was introduced and applied to achieve the associated requirements of safety. As the original MSDD lacked the requirements and solutions for the safety component, an updated version of the MSDD has been proposed to incorporate the safety branch to the MSDD.In addition, some enhancements to the current version of the MSDD have been made for a clearer and more thorough understanding of the system design.
Sozioökonomische Faktoren und Verbreitung von Adipositas
Creators: name: Kuntz, Benjamin
name: Lampert, Thomas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2010
Subjects: subject: Sozialstatus
subject: Übergewicht
subject: Gesundheitsforschung
subject: Soziale Befindlichkeit
subject: Studie
subject: 610 Medizin

description: Hintergrund: Aus verschiedenen Studien ist bekannt, dass die Verbreitung von Adipositas einem sozialen Gradienten folgt. Untersucht wird, welche relative Bedeutung den Statusindikatoren Einkommen, Bildung und berufliche Stellung zukommt. Methode: Datenbasis war der telefonische Gesundheitssurvey 2003 (n = 8 318), der repräsentative Ergebnisse für die Wohnbevölkerung ab 18 Jahren in Deutschland liefert. Als sozioökonomische Faktoren werden das äquivalenzbilanzierte Haushaltsnettoeinkommen, der höchste allgemeinbildende Schulabschluss und die Autonomieskala des beruflichen Handelns nach Hoffmeyer-Zlotnik herangezogen. Dargestellt werden alters- und geschlechtsspezifische Prävalenzen sowie durch binär logistische Regressionen ermittelte Odds Ratio mit 95-%-Konfidenzintervallen. Ergebnisse: Im Jahr 2003 waren rund 17 Prozent der über 18-jährigen Männer und 20 Prozent der gleichaltrigen Frauen adipös. Bei statistischer Kontrolle des Alterseinflusses und der jeweils anderen beiden Statusindikatoren haben bei Männern sowohl der höchste allgemeinbildende Schulabschluss als auch die berufliche Stellung einen signifikanten Effekt. Bei Frauen bleibt der Sozialgradient für alle drei Dimensionen des sozioökonomischen Status bestehen. Frauen aus der niedrigsten Einkommensgruppe haben eine um den Faktor 3 erhöhte Chance, von Adipositas betroffen zu sein im Vergleich zu Frauen aus der höchsten Einkommensgruppe. Schlussfolgerung: Aufgrund der zunehmenden Verbreitung und ihrer Relevanz für zahlreiche Folgeerkrankungen bildet die Bekämpfung von Adipositas ein vorrangiges Ziel der Gesundheitspolitik. Die vorliegenden Ergebnisse verweisen auf die Bedeutung sozioökonomischer Faktoren. Zielgruppenspezifische Präventionsmaßnahmen und adäquate Behandlungsangebote sollten diesem Umstand verstärkt Rechnung tragen.
Additional file 2 of DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation
Creators: name: Gómez, Rodolfo
name: Barter, Matt J.
name: Alonso-Pérez, Ana
name: Skelton, Andrew J.
name: Proctor, Carole
name: Herrero-Beaumont, Gabriel
name: Young, David A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Model design. A computational model of Bmp2 signalling was constructed to evaluate ALP induction in the context of ZEB TFs activity.
Pasta with cholesterol-lowering effect on human health
Creators: name: PAGLIARO, ANTONELLA
Publisher: name: Universit� degli Studi di Foggia
Year: 2019

description: La pasta � un alimento consumato giornalmente che provvede a fornire energia, interviene nella percezione del senso di saziet� ed esercita effetti positivi sulla salute umana. Inoltre la pasta rappresenta un buon veicolo per l?assunzione di biomolecole essendo uno degli alimenti principali della dieta mediterranea. Scopo principale di questo lavoro, � stato ottenere nuove paste funzionali ad azione ipocolesterolemizzante. Per raggiungere l?obiettivo connesso con l?attivit� di ricerca � stata effettuata la valutazione delle propriet� reologiche, sensoriali e chimiche di paste prodotte con farina di grano duro commerciale addizionate con lenticchia siciliana (Lens culinaris Medik) ricca in amminoacidi essenziali, cladodi di popolazioni siciliane di fichi d?india (Opuntia ficus-indica (L.) Mill ricchi in fibre, specie selvatiche siciliane di portulaca (Portulaca oleracea L.) ricche in acidi grassi e farina di avena ricca in ?-glucani. Grazie all?uso dell?additivo alimentare carbossimetilcellulosa (CMC), gli spaghetti arricchiti con il 40% di lenticchia presentavano una buona valutazione sensoriale e un miglioramento della qualit� in cottura. Tutte le paste arricchite in lenticchia sono risultate una buona fonte di amminoacidi essenziali, l?aggiunta della lenticchia di Ragusa ha aumentato il contenuto di Lys, Val, Ile, Gly e Asp, mentre l?aggiunta della lenticchia commerciale ha aumentato il contenuto in Leu, Thr, Ser e Lys. Con riferimento alle paste alimentari arricchite con il 5% e 10% di cladodi di ficodindia e CMC � stato possibile ottenere sufficienti caratteristiche sensoriali, ma buone caratteristiche nutraceutiche, essendo risultate fonte di fenoli e fibre. Riguardo l?aggiunta di farine di portulaca, l?analisi sensoriale delle paste prodotte ha mostrato che il giudizio globale diminuiva considerevolmente negli spaghetti con il 15% di portulaca, mentre quelli con il 10% di portulaca sono stati apprezzate. Le analisi chimiche hanno evidenziato che la pasta arricchita in portulaca ha tutto il potenziale per essere un cibo funzionale, grazie al suo contenuto in acidi grassi e la sua capacit� antiossidante. Tutte le paste arricchite con quattro diverse concentrazioni di avena hanno avuto punteggi positivi nell?analisi sensoriale. I ?-Glucani sono stati estratti e caratterizzati nell?avena aggiunta e negli spaghetti prodotti. Il contenuto in ?-Glucani aumentava aumentando la concentrazione di avena aggiunta e soprattutto non sono state riscontrate perdite dopo il processo di cottura. In generale, i livelli di accettabilit� raggiunti da parte dei consumatori, abbinate alle evidenze nutrizionali e chimiche dei prodotti ottenuti rappresentano un punto di partenza per ulteriori ricerche in campo clinico, al fine di valutare l'effetto diretto sul livello del colesterolo in pazienti affetti da ipercolesterolemia.
2-Pyrazoline derivatives in neuropharmacology: synthesis, ADME prediction, molecular docking and in vivo biological evaluation
Creators: name: Upadhyay, Savita
name: Tripathi, Avinash C.
name: Paliwal, Sarvesh
name: Saraf, Shailendra K.
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2017
Subjects: 4,5-dihydro-(1H)-pyrazoles
antidepressant
anxiolytic
MAO inhibitors
neurotoxicity
microwave synthesis
molecular docking

description: A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (PFC-1 to PFC-16) were synthesized in a three step reaction using conventional and microwave assisted green chemistry approach. The synthesized derivatives were characterized and their chemical structures were established by various physicochemical methods such as IR, Mass, 1H-NMR, 13C-NMR and elemental analysis. The synthesized compounds were tested for their neuropharmacological potential. The compounds exhibited significant antidepressant and anti-anxiety activities against various behavioral in vivo models. Compounds PFC-3 and PFC-12 were found to be the most active derivatives in the series. The 2-pyrazoline analogs, having 2-hydroxyphenyl and anthracen-9-yl substitution at 3rd position while 4-benzyloxyphenyl and 4-methylphenyl substitution at 5th position, were decisive in eliciting good antidepressant and anxiolytic properties, respectively. The docking experiments revealed that the synthesized derivatives were potential inhibitors of MAO-A protein, which plays a central role in managing depression and anxiety disorders. The most potent derivatives were found to be involved in some key interactions with Tyr407, Tyr444, Phe352 and Ala68 amino acid residues at the binding site of MAO-A protein. All the synthesized derivatives successfully passed the pharmacokinetic barriers of absorption, distribution, metabolism and elimination as predicted using in silico techniques without showing any substantial indication of acute and neurotoxicity. This was further confirmed in the laboratory by performing acute toxicity studies as per OECD guidelines.
description: EXCLI Journal; 16:Doc628; ISSN 1611-2156
Additional file 1 of Primary care pediatricians and job satisfaction: a cross sectional study in the Lazio region
Creators: name: Sapienza, Martina
name: Furia, Giuseppe
name: La Regina, Domenico Paolo
name: Grimaldi, Valentina
name: Tarsitano, Maria Grazia
name: Patrizi, Cristina
name: Capelli, Giovanni
name: Damiani, Gianfranco
Publisher: name: figshare
Year: 2024
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1 Supplementary Appendix.
Chronon Field Theory: Unification of Gravity and Gauge Interactions via Temporal Flow Dynamics
Creators: name: Li, Bin
Publisher: name: Zenodo
Year: 2025
Subjects: Chronon Field Theory, unified field theory, topological solitons, temporal flow, emergent spacetime, quantum gravity, causal structure, lattice simulation, real now, field theory, particle emergence, topological defects, symmetry breaking, renormalization, gauge theory

description: We introduce Chronon Field Theory (CFT), a unified framework in which the fundamental field is a unit-norm, future-directed timelike vector Phi^mu(x) representing the local direction and coherence of temporal flow, termed the "Real Now." Unlike conventional quantum field theories, where particles are postulated and spacetime is fixed, CFT treats time itself as a causal, evolving field from which matter, forces, and geometry emerge.

In this formulation, gravitational, gauge, and matter phenomena arise from distinct deformation modes of Phi^mu: gravity from large-scale coherent curvature; electromagnetism from local U(1) phase rotations; weak interactions from parity-violating shear; and strong interactions from topological flux tubes. Fermions are modeled as topological solitons classified by pi_3(S^3), with spin, mass, and quantum statistics arising from internal winding structures. The Higgs mechanism is replaced by mass generation via Chronon field deformation energy.

CFT is shown to be canonically quantizable and perturbatively renormalizable at one loop. It reproduces standard model results in the low-energy limit and predicts observable deviations in scattering amplitudes and hadronization. Large-scale lattice simulations of Chronon dynamics reveal the spontaneous formation of stable, quantized solitons—providing computational evidence that matter may emerge from the topology of time itself.

CFT is canonically quantizable, perturbatively renormalizable, and intrinsically finite due to its smooth

solitonic structure—eliminating ultraviolet divergences without counterterms.

Chronon Field Theory thus offers a first-principles reformulation of fundamental physics grounded in the dynamics and geometry of time. It fulfills key aspects of Einstein’s vision of unification and opens a new simulation-based paradigm for discovering high-energy phenomena beyond collider experiments.
Flupirtiini kasutamisele kehtestatud piirangute järgimine
Creators: name: Kurvits, Katrin
name: Uusküla, Maia
name: Laius, Ott
name: Vestman, Helve
Publisher: name: Eesti Arst
Year: 2018

description: Eesti Arst 2018; 97(4):220–224
description: Eesti Arst, Aprill 2018
Data from: Artabotrys rubriflorus (Annonaceae), a new species from Yunnan China
Creators: name: Liu, Yunqian
name: Ye, Wen
Publisher: name: Zenodo
Year: 2025
Subjects: Artabotrys
Nucleotide sequencing
phylogeny

description: Artabotrys rubriflorus sp. nov. is described as a new species of Annonaceae, collected from Malipo, Yunnan Province, China.The specimens of this new species were gathered through fieldwork and were subsequently subjected to rigorous analysis using both classical taxonomical methods and molecular phylogenetic analysis. The phylogenetic reconstruction, based on four chloroplast DNA regions (matK, rbcL, trnLF, and psbAtrnH), was carried out employing maximum parsimony, maximum likelihood and Bayesian inference approaches. These analyses confirmed the systematic positioning of Artabotrys rubriflorus sp. nov. within the genus Artabotrys, while also establishing its distinctiveness from other species.
description: Funding provided by: National Natural Science Foundation of ChinaROR ID: https://ror.org/01h0zpd94Award Number: 30870147
Funding provided by: National Natural Science Foundation of ChinaROR ID: https://ror.org/01h0zpd94Award Number: 31270234
description: Chloroplast genomic DNA was extracted from collected silica-dried leaves (Narzary et al. 2015) using the Ezup Spin Column Super Plant Genomic DNA Extraction Kit (Sangon Biotech, Shanghai). Four chloroplast DNA regions (matK, rbcL, trnL-F and psbA-trnH) were subjected to PCR amplification. Primer information is given in Table 3. The PCR reaction system (25 µl) consisted of 15 µl of 2 Taq Master Mix buffer, 10 µl of ddH2O, 3 µl of the primer mixture (1.5 µl each of the positive and reverse primer), and 2 µl of the DNA template. The parameters for PCR procedure was 95 for 3 min, followed by 40 cycles of 95 for 30 s, appropriate annealing temperature for 30 s, 72 for 1 min, and 10 min for final extension at 72 , the annealing temperatures was 54 for matK and rbcL genes, 49 for trnL-F and psbA-trnH intergenic spacers. 5 µl of the products were tested using electrophoresis in 1% agarose gel at 150 V, 110 mA for 10 to 20 min. San Prep Column DNA Gel Extraction Kit (Sangon Biotech, Shanghai) was used for recovery and purification, then the purified products were sequenced by Sangon Biotech (Shanghai, China  https://www.sangon.com/).
Multidistsiplinaarne geriaatriline hindamine – võimalus eaka inimese probleemide ja vajaduste objektiivseks hindamiseks ning ressursside otstarbekaks kasutamiseks
Creators: name: Kolk, Helgi
Publisher: name: Eesti Arst
Year: 2018

description: Eesti Arst 2018; 97(4):225–227
description: Eesti Arst, Aprill 2018
Additional file 9 of DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation
Creators: name: Gómez, Rodolfo
name: Barter, Matt J.
name: Alonso-Pérez, Ana
name: Skelton, Andrew J.
name: Proctor, Carole
name: Herrero-Beaumont, Gabriel
name: Young, David A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9: Figure S4. Computational simulation of Zeb1 and Zeb2 interaction in the context of BMP2-induced target gene expression.
Transparent and Mutual Restraining Electronic Voting
Creators: name: Li, Huian
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Theory of computation not elsewhere classified
System and network security
Cryptography

description: Many e-voting techniques have been proposed but not widely used in reality. One of the problems associated with most of existing e-voting techniques is the lack of transparency, leading to a failure to deliver voter assurance. In this work, we propose a transparent, auditable, end-to-end verifiable, and mutual restraining e-voting protocol that exploits the existing multi-party political dynamics such as in the US. The new e-voting protocol consists of three original technical contributions -- universal verifiable voting vector, forward and backward mutual lock voting, and in-process check and enforcement -- that, along with a public real time bulletin board, resolves the apparent conflicts in voting such as anonymity vs. accountability and privacy vs. verifiability. Especially, the trust is split equally among tallying authorities who have conflicting interests and will technically restrain each other. The voting and tallying processes are transparent to voters and any third party, which allow any voter to verify that his vote is indeed counted and also allow any third party to audit the tally. For the environment requiring receipt-freeness and coercion-resistance, we introduce additional approaches to counter vote-selling and voter-coercion issues. Our interactive voting protocol is suitable for small number of voters like boardroom voting where interaction between voters is encouraged and self-tallying is necessary; while our non-interactive protocol is for the scenario of large number of voters where interaction is prohibitively expensive. Equipped with a hierarchical voting structure, our protocols can enable open and fair elections at any scale.
Chronon Field Theory: Unification of Gravity and Gauge Interactions via Temporal Flow Dynamics
Creators: name: Li, Bin
Publisher: name: Zenodo
Year: 2025
Subjects: Chronon Field Theory, unified field theory, topological solitons, temporal flow, emergent spacetime, quantum gravity, causal structure, lattice simulation, real now, field theory, particle emergence, topological defects, symmetry breaking, renormalization, gauge theory

description: We introduce Chronon Field Theory (CFT), a unified framework in which the fundamental field is a unit-norm, future-directed timelike vector Phi^mu(x) representing the local direction and coherence of temporal flow, termed the "Real Now." Unlike conventional quantum field theories, where particles are postulated and spacetime is fixed, CFT treats time itself as a causal, evolving field from which matter, forces, and geometry emerge.

In this formulation, gravitational, gauge, and matter phenomena arise from distinct deformation modes of Phi^mu: gravity from large-scale coherent curvature; electromagnetism from local U(1) phase rotations; weak interactions from parity-violating shear; and strong interactions from topological flux tubes. Fermions are modeled as topological solitons classified by pi_3(S^3), with spin, mass, and quantum statistics arising from internal winding structures. The Higgs mechanism is replaced by mass generation via Chronon field deformation energy.

CFT is shown to be canonically quantizable and perturbatively renormalizable at one loop. It reproduces standard model results in the low-energy limit and predicts observable deviations in scattering amplitudes and hadronization. Large-scale lattice simulations of Chronon dynamics reveal the spontaneous formation of stable, quantized solitons—providing computational evidence that matter may emerge from the topology of time itself.

Chronon Field Theory thus offers a first-principles reformulation of fundamental physics grounded in the dynamics and geometry of time. It fulfills key aspects of Einstein’s vision of unification and opens a new simulation-based paradigm for discovering high-energy phenomena beyond collider experiments.
Complete Genome Sequence of a Wild-Type Measles Virus Isolated during the Spring 2013 Epidemic in Germany
Creators: name: Sparrer, Konstantin M. J.
name: Krebs, Stefan
name: Jäger, Gundula
name: Santibanez, Sabine
name: Mankertz, Annette
name: Blum, Helmut
name: Conzelmann, Karl-Klaus
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2014
Subjects: subject: 610 Medizin

description: Measles virus induces an acute disease with rash and fever. Despite ongoing vaccination and elimination campaigns, the measles virus still sustains long-lasting transmission chains in Europe. Here we report the complete genome sequence of a wild-type measles virus isolated from a patient in Munich (MVi/Muenchen.DEU/19.13[D8]) during a German measles outbreak in 2013.