cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ECO-LOAN: ENVIRONMENTALLY FRIENDLY SOFT LOAN SYSTEM FOR MSMEs ENVIRONMENT-BASED IN INDONESIA
Creators: name: SALMAN MUFID
Publisher: name: figshare
Year: 2020
Subjects: subject: 140205 Environment and Resource Economics
subject: FOS: Economics and business

description: Referring to the problem from the MSMEs in Indonesia, currently the institution the banking sector does not yet have a specific scheme intended to encourage SMEs to be environmentally friendly, but they already have a CSR program refers to the same goal, the Community Development Partnership Program (PKBL), where the program is directed to provide guidance to businesses the purpose of micro and small is to support development and improvement UMKM competence which is the driving wheel of the people's economy Answering appropriate problems from national and international funds ( PAE, IEPC and DNS) and their relation to the goal of sustainable development in the environmental field we need an Eco-Friendly Soft Loan (ECO LOAN) system that provides effective, efficient and targeted solutions in distribution loan funds in the form of investments and capital for MSMEs in Indonesia. The ECO-LOAN system also provides friendly eligibility assessment requirements environment. For MSMEs who pass the test and have spot checks and continue on stage of type of loan by the implementing bank. Stakeholders involved include is the implementing bank, economic and environmental consultant, Ministry Environment (KLH). This system also provides friendly business training environment so that MSME businesses can understand the goals of the green economy which drives sustainable development goals (SDGs).
(501329) Andrew Stewart
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Alternative Splicing is Coordinated by RNA-binding Proteins and Impacts Transcript Stability During Myogenesis
Creators: name: Cafaro, Hannah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Alternative splicing of pre-mRNA is a co- and post-transcriptional process that occurs in more than 90% of human genes. By selectively including or excluding specific regions, alternative splicing expands the proteome from a limited number of genes. Tissue-specific RNA-binding proteins (RBPs) bind sequences surrounding an alternative exon to control splicing decisions. Interestingly, the stability of an alternative splice form can affect whether the mRNA is translated into a functional protein. However, it is not known how RBPs and transcript stability might contribute to isoform-specific expression during skeletal muscle development and differentiation (myogenesis). Here, we hypothesized that alternative splicing is governed in part by specific RBPs during myogenesis and that the stability of splice isoforms contributes to how these isoforms function in the regulation of muscle maturation. To investigate the regulation and expression of alternative splice forms in muscle, we utilized the mouse C2C12 muscle cell line that undergoes myogenesis and mimics developmental splicing transitions observed in skeletal muscle in vivo. We found that the RBPs muscle-blind (MBNL) 1, MBNL2, polypyrimidine tract binding protein (PTBP) 1, and PTBP2 were downregulated during myogenesis while CUGBP elav-like family member 2 (CELF2) was upregulated, as measured by western blot. Expression of the CELF1 and quaking (OKI) proteins were unchanged during myogenesis. Several splicing transitions were altered during C2C12 cell differentiation when specific RBPs were depleted. We further demonstrated that alternatively spliced exons from several genes contribute to transcript stability by either promoting or inhibiting mRNA degradation. Alternative exons may alter microRNA binding sites, and we have identified potential binding sites in transcripts with different stabilities. Together, these data implicate a complex model of specific temporal regulation of alternatively spliced gene expression in muscle, which could be used in the future as a potential therapeutic mechanism to understand and combat disease progression.
Heat Shock Response in the Tardigrade Dactylobiotus dispar
Creators: name: Barber, Heather
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Tardigrades are microscopic invertebrates well-known for their ability to survive extremes such as desiccation or temperature stress by entering a dormant state where metabolism is slowed. Two of the mechanisms by which this achieved are entry into the quiescent state of anhydrobiosis (called a ‘tun’) and the diapause state of encystment. In order to measure and understand the effects of both anhydrobiosis and encystment on tardigrade biology, it is necessary to know what they can survive in their normal, active state. To measure the effect of heat shock on the tardigrade Dactylobiotus dispar, a species which is known to encyst, tardigrades were exposed to a gradient of temperatures and their percent survival after exposure was determined. This was done for a variety of exposure durations to generate graphs showing the proportion of survival at each temperature per duration of exposure and to determine a median lethal temperature (LT50) for each duration. When compared to another tardigrade species, Hypsibius exemplaris, which is known to enter anhydrobiosis, a greater proportion of D. dispar survived at each temperature on average per duration of heat shock. Since D. dispar have not been observed to enter a tun, it is possible that this relative increase in heat shock survivability in the active state may be a way of compensating for an inability to enter tun. Due to insufficient knowledge about heat shock protein production in each tardigrade, it is difficult to determine if there is a difference in type or amount of protectants produced between the two species. Future directions include the establishment of RNAi in Dactylobiotus dispar so that we can test the function of individual genes in the heat shock response.
Additional file 14 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 14 Foa race 4 putative accessory chromosomes: percentage of genes that have homologs in other strains
Novel leaf morphology and variation in foliage similar to Rhacopteris from the Early Carboniferous Price Formation, southwestern Virginia, USA
Creators: name: Knier, Aubrey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The plant fossil foliage genus Rhacopteris existed approximately 350 million years ago in the Lower Carboniferous and conforms to seed fern organization and affinity. A collection of foliage similar to Rhacopteris has been found in one of several outcrops of the Price Formation near Pulaski, Virginia, North Carolina, USA. While superficially resembling previously described Rhacopteris species, about 30 individuals of the collection (labeled PGR) exhibit a distinctive bilobed leaflet morphology that is unlike those described for any existing Rhacopteris species. This project aims to determine whether the specimens of the PGR collection represent a single taxon or more than one related taxa, and if they are most appropriately assigned to the genus Rhacopteris as an existing or new species? In order to determine the affinity of these specimens, quantitative and qualitative morphological measurements of both published Rhacopteris specimens and the PGR specimens exhibiting the distinct bilobed leaflet morphology from the Price Formation were obtained and analyzed. Methods include dégagement (a process of uncovering any leaf parts obscured by the rock matrix), measuring leaflet length, leaflet perimeter, leaflet surface area, rachis internode length, and depth of lobing with ImageJ, leaf transverse sectioning, and illustrating specimens and simulating taphonomic distortion with Adobe Illustrator. The distinct bilobed leaflet shape and venation pattern of the PGR specimens were found to be notably distinct from all previously described species of Rhacopteris, thus supporting that the collection under study represents a single new species. This work will contribute to a better understanding and classification of the floral composition of a region considered to have a wet-dry climate, and to our overall knowledge regarding the plant distribution of early seed plants in the Lower Carboniferous.
Additional file 17 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 17 The percentage identity of the Secreted In Xylem 1 (SIX1) orthologs in the Foa, Foci, and reference strain
Additional file 18 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 18 Test of PCR primers for Foa races 2 and 4 and Foci on a diversity of Fusarium spp.
Evolving Chromodomain Reader Domains for Non-Natural Histone Mark Recognition
Creators: name: Watters, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The development of new methods to bind and enrich histones that contain specific, non-natural histone PTMs has broad reaching implications to better understand many crucial biological processes, such as replication, transcription, and mitosis. To evolve a chromodomain reader protein, a Cbx1 gene III phage display strategy was developed and characterized in a phage ELISA system to replicate previously characterized binding data of a suite of Cbx1 binding probes ranging from Kd values of 320 µM to 130 nM. To accurately characterize these binding dynamics, it was necessary to incorporate at least 1/10th the amount of biotin to the amount of biotinylated peptide. Four parallel phage display selections were completed to attempt to evolve stronger binders to H3K9me3 and H3K9me3S10p from a naïve library of five amino acid randomized NNK codons in the EPEEN region rationally targeted by structural and computational information. The selection process showed greater than ten-fold enrichment for selections to the different histone tail peptides, and NGS data showed that the WT Cbx1 sequence was highly enriched in both libraries, and an additional RAWMI mutant was moderately enriched in the H3K9me3S10p selection and not as strongly selected against as other amino acids in the H3K9me3 selection. The Cbx1 RAWMI mutant protein has not shown any measurable binding via ITC to either of the H3 PTM peptides. This study sets the stage for future evolution of reader domains for improved function as a biological enrichment tool.
(501325) Mulfred Evans Carmichael
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Alpha cluster structures and monopole excitations in $^{13}$C
Creators: name: Yamada, Taiichi
name: Funaki, Yasuro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The structure of $1/2^{\pm}$ states in $^{13}$C up to around the $3α+n$ threshold ($E_x = 12.3$~MeV) is investigated with a full four-body $3α+n$ orthogonality condition model (OCM) calculation, where the $3α$ OCM, the model space of which is the subspace of the $3α+n$ model, describes well the structure of the low-lying states of $^{12}$C including the $2^{+}_2$, $0^{+}_3$, and $0^{+}_4$ states, which have been recently observed above the Hoyle state ($0^+_2$). A full spectrum up to the $1/2^{-}_5$ ($1/2^{+}_3$) state is reproduced consistently with the lowest five $1/2^{-}$ (three $1/2^{+}$) states of experimental spectrum. It is shown that the $1/2^{-}_2$ and $1/2^{-}_3$ states are characterized by the dominant cluster configurations of $^{9}$Be($3/2^-$,$1/2^-$)+$α$, while the ground state $1/2^-_1$ has a shell-model-like structure. The observed monopole transition strengths to the $1/2^{-}_{2,3}$ states are consistently reproduced for the first time. These results indicate that the excited $1/2^-$ states have cluster structures. They are compared to those by the previous work with the shell model. On the other hand, the $1/2^{+}_{1}$ state is found to have a loosely bound neutron structure in which the extra neutron moves around $^{12}$C(g.s) core with $1S$ orbit, reflecting the fact that this state appears by $1.9$ MeV just below the $^{12}$C(g.s)+$n$ threshold, while the $1/2^{+}_{2}$ and $1/2^{+}_{3}$ states are characterized by $^{9}$Be+$α$ structures. We found that the $1/2^+_5$ state located above the $3α+n$ threshold is the Hoyle analogue state in $^{13}$C, the wave function of which is described by product states of constituent clusters, $(0S)^3_α(S)_n$, with the probability of $52$ %.
description: 39 pages, 9 figures, version accepted for publication in Physical Review C
HOPS 383: An Outbursting Class 0 Protostar in Orion
Creators: name: Safron, Emily J.
name: Fischer, William J.
name: Megeath, S. Thomas
name: Furlan, Elise
name: Stutz, Amelia M.
name: Stanke, Thomas
name: Billot, Nicolas
name: Rebull, Luisa M.
name: Tobin, John J.
name: Ali, Babar
name: Allen, Lori E.
name: Booker, Joseph
name: Watson, Dan M.
name: Wilson, T. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the dramatic mid-infrared brightening between 2004 and 2006 of HOPS 383, a deeply embedded protostar adjacent to NGC 1977 in Orion. By 2008, the source became a factor of 35 brighter at 24 microns with a brightness increase also apparent at 4.5 microns. The outburst is also detected in the submillimeter by comparing APEX/SABOCA to SCUBA data, and a scattered-light nebula appeared in NEWFIRM K_s imaging. The post-outburst spectral energy distribution indicates a Class 0 source with a dense envelope and a luminosity between 6 and 14 L_sun. Post-outburst time-series mid- and far-infrared photometry shows no long-term fading and variability at the 18% level between 2009 and 2012. HOPS 383 is the first outbursting Class 0 object discovered, pointing to the importance of episodic accretion at early stages in the star formation process. Its dramatic rise and lack of fading over a six-year period hint that it may be similar to FU Ori outbursts, although the luminosity appears to be significantly smaller than the canonical luminosities of such objects.
description: Accepted by ApJ Letters, 6 pages, 4 figures; v2 has an updated email address for the lead author
(501326) Ellen M Carmichael
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501327) Alice Lavinia Carmichael
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Multi-Heuristic Approach for Solving the Pre-Marshalling Problem
Creators: name: Jovanovic, Raka
name: Tuba, Milan
name: Voss, Stefan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences

description: Minimizing the number of reshuffling operations at maritime container terminals incorporates the Pre-Marshalling Problem (PMP) as an important problem. Based on an analysis of existing solution approaches we develop new heuristics utilizing specific properties of problem instances of the PMP. We show that the heuristic performance is highly dependent on these properties. We introduce a new method that exploits a greedy heuristic of four stages, where for each of these stages several different heuristics may be applied. Instead of using randomization to improve the performance of the heuristic, we repetitively generate a number of solutions by using a combination of different heuristics for each stage. In doing so, only a small number of solutions is generated for which we intend that they do not have undesirable properties, contrary to the case when simple randomization is used. Our experiments show that such a deterministic algorithm significantly outperforms the original nondeterministic method when the quality of found solutions is observed, with a much lower number of generated solutions.
Investigating the Mucin and Bacterial Binding Properties of Innate Lung Protein LPLUNC1 (BPIFB1)
Creators: name: Troyer, Sophie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Mucins are large macromolecules that give mucus its major biophysical properties, such as viscosity and elasticity, that protect mucosal surfaces, including the lungs. Prevalent chronic lung diseases such as COPD, asthma, and cystic fibrosis (CF) are characterized by mucus/mucin hypersecretion and hyperconcentration. Our lab previously described that dominant airway mucins MUC5B and MUC5AC interact with crucial innate immune proteins including LPLUNC1 (also known as BPIFB1). The role of LPLUNC1 in innate lung defense and its interaction with mucins is unknown. To assess LPLUNC1 interactions with MUC5B and MUC5AC as well as with bacterial components, we overexpressed LPLUNC1 using the pCMV plasmid vector in HEK293T cells and collected extracellular LPLUNC1. This protein was purified using a series of columns: anti-Flag affinity, size exclusion, and anion exchange. After size exclusion, the chromatogram, SDS page gel electrophoresis, and mass spectrometry confirmed the correct molecular weight and sufficient purity of the protein for further experiments. SDS page gel electrophoresis suggested that this protein may be multimeric in nature; this novel observation tells us about the molecular organization of LPLUNC1. To better understand the interaction between LPLUNC1 and mucins, and LPLUNC1 and bacterial components, Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) was utilized. These preliminary experiments using QCM-D suggest that LPLUNC1 interacts with MUC5AC but not MUC5B, and that the glycans on MUC5AC play a role in this interaction. Characterizing this interaction would be important for understanding the macromolecular basis of how airway mucus organizes, how it provides innate immune protection in health, and how it contributes to pathogenesis of muco-obstructive lung diseases such as chronic bronchitis and cystic fibrosis. Other preliminary findings from QCM-D suggest that LPLUNC1 may interact with bacterial components such as LPS and ​Pseudomonas ​ ​aeruginosa ​ membrane proteins. This may indicate bactericidal function, possibly involving crosslinking with MUC5AC in a mechanism that could result in trapping the bacteria in the mucus and clearing them with mucociliary clearance. Future studies will assess the putative binding sites on the proteins and on the bacterial surface that provide crucial information about how innate immunity in the lung works and how it can be manipulated for therapeutic purposes.
(501328) Frank H[unter] Butterworth
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 16 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 16 Up-expressed in planta RNA TagSeq-predicted effectors in Foa race 4: sequences, distribution, and mimp associations
Household Food Insecurity, Maternal BMI, and Exclusive Breastfeeding Practices in mothers in Zambia: a mixed methods approach and analysis
Creators: name: Lakshmi Meenakshi Immaneni
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: Nutrition

description: Optimal infant and young child feeding (IYCF) practices are fundamental to survival, growth, development, health and nutrition of infants and children and to the well-being of the mothers. Exclusive breastfeeding for the first 6 months is defined by the WHO as one of the indicators of appropriate IYCF practices. This project employed quantitative and qualitative methods to address the following research questions: 1) How is household food security related to exclusive breastfeeding practices in Zambia? Does this relationship differ by province? 2) How is maternal BMI (i.e. underweight and overweight/obesity) related to exclusive breastfeeding practices in Zambia? Does this relationship differ by province? 3) What are facilitators and barriers to exclusive breastfeeding for mothers according to key informants from different government sectors?
(501322) Arthur Greig
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Developing tools for genetic manipulation of the tardigrade species Hypsibius exemplaris
Creators: name: Shaljian, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Tardigrades are microscopic organisms being developed as an emerging model system because of their biological ability to withstand extremes. Access to the genetic machinery that controls tardigrades’ function is crucial for understanding the mechanisms by which they operate biologically and for enriching the research that could be done on them. To get such access, we have been developing experimental tools to enable further research on tardigrades in two distinct projects: one involving the use of RNA interference to identify a non-essential gene with a visible phenotype, and another that tests the ability of tardigrades to express exogenously produced mRNAs and plasmids. RNA interference has been successful in the tardigrade species Hypsibius exemplaris, but only in targeting genes that are essential to the development of the organism. Currently, no non-essential genes whose disruption by RNAi results in a visible phenotype are known. In this research, I attempt to identify such a gene, which would not only serve as the only non-lethal phenotype in this organism for genetic manipulations, but also as a target for the future use of CRISPR-Cas 9 methods to develop transgenic tardigrades. To find non-essential genes that would produce a phenotype, I identified genes involved in pigment pathways of the related species Drosophila and found their homologs in Hypsibius exemplaris. I synthesized double-stranded RNAs to target these genes and injected them into adults, then isolated and observed their embryos. Since tardigrades only show pigment at their eyespots, the RNAi was expected to disrupt the production of pigment in the eyes. Although the desired phenotype has yet to be seen, additional genes exist which have yet to be targeted. The future identification of a non-essential gene target is a crucial element to developing transgenic tardigrades via CRISPR-Cas9 methods, a tool which would allow for a deeper understanding of the genetic mechanisms behind tardigrades’ ability to respond to stress. We also tested the ability of tardigrades to express exogenously produced mRNAs and plasmids encoding fluorescent proteins by injecting them into the organisms and observing them for signs of fluorescence. This research demonstrates the first evidence that tardigrades are capable of expressing foreign mRNA introduced by injection.
Additional file 19 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 19 Whole genome-sequenced Fusarium spp. included in analyses in GenBank wgs
The Role of Axl in Remyelination and Oligodendrocyte Progenitor Cell Differentiation
Creators: name: Tishad, Abtahi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Multiple sclerosis is an autoimmune disorder in which the body’s immune cells target the myelin sheath produced by oligodendrocytes and leads to demyelinating lesions within the central nervous system. Subsequent to demyelination, oligodendrocyte precursor cells (OPCs) either locally or from the subventricular zone will migrate to the site of lesion and eventually differentiate into myelin-producing mature oligodendrocytes to replace the lost myelin. This process, known as remyelination, is likely an interaction of microglia with OPCs. Microglia have been shown to support remyelination in the CNS after demyelination via clearance of debris, secretion of growth factors and cytokines, and modulation of the extracellular matrix. However, the exact mechanisms are only partly elucidated. Our project focuses on Axl, a membrane tyrosine kinase receptor found on macrophages, microglia and OPCs. Prior experiments have suggested that Axl -/- mice have prolonged axonal damage relative to WT mice after cuprizone induced demyelination. Through LFB-PAS staining, we showed that the lack of Axl leads to significant delay in remyelination. To explain such a delay, we hypothesized that factors secreted by macrophages post-phagocytosis of apoptotic cells can accelerate the differentiation of OPCs in an Axl-dependent manner. From examining the supernatants of apoptotic cell-stimulated macrophages from WT and Axl-/- mice, we found that Axl -/- macrophage supernatants were significantly less potent in OPC differentiation relative to WT supernatants. Thus, Axl may play a regulatory role in a process which guides remyelination and OPC differentiation.
We Had to Start Somewhere: Applying the Anti-Racist LibGuide Framework Created by Jaime Ding and the Cal Poly Team
Creators: name: Asuquo, Sarah
name: Cawley, Michelle
name: Welker, Carolyn
name: Conklin, Jamie
name: Ding, Jaime
name: Torian, Stacy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: A team from the Health Sciences Library (HSL) applied an anti-racist framework, developed by a team from Cal Poly led by Jaime Ding, to a pilot batch of HSL LibGuides. The HSL team adapted Cal Poly’s rubric for assessing LibGuides and developed tiered recommendations, based on effort and time required, that liaison librarians can apply to their LibGuides. In the session, presenters provided an overview of Ding’s approach; shared practical approaches for updating LibGuides using the framework; discussed lessons learned and strategies to address potential resistance to suggested changes; and offered resources to participants, including a rubric and recommendations around how to conduct a “tiered” anti-racism review of LibGuides. The session included a facilitated small-group activity and a group discussion.
(501323) Mabel I Roberts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
It Is Not Just About Enrollment: Recognizing the Impact of RCT Recruitment Approaches on Prediabetes Awareness, Screening, and Capacity Building in African American Communities
Creators: name: Faurot, K.R.
name: Woods-Giscombe, C.L.
name: Gaylord, S.A.
name: Lynch, C.
name: Phillips, P.
Publisher: name: Springer
Year: 2021

description: Diabetes is a growing epidemic in the USA. Compared to white Americans, African Americans are 1.8 times more likely to have diabetes [1]. Additionally, African Americans with diabetes experience higher rates of morbidity and mortality than other racial groups. Compared to whites, African Americans are twice as likely to suffer from diabetes-related blindness, 1.5 to 2.5 times more likely to suffer from lower limb amputations and 2.6 to 5.6 times more likely to suffer from kidney disease [1, 2]. Prediabetes is a common precursor to diabetes and characterized by blood glucose levels that are above normal but below the criteria for a diagnosis of diabetes [3]. Approximately 30% or 88 million US adults have prediabetes [4] with African Americans disproportionately affected. During the average 3 years of follow-up of the landmark Diabetes Prevention Program, prediabetes developed into type 2 diabetes in approximately 11% of the subjects who participated in the standard care or control group [5]. Other estimates show that if prevention strategies are not implemented, individuals with prediabetes will be diagnosed with type 2 diabetes within 10 years [6]. While African Americans with prediabetes are at significant risk for developing diabetes, this outcome is not inevitable. Diagnosis of prediabetes is an example of secondary prevention, screening to identify diseases at an early stage, before symptoms begin [7]. The identification of pre-diabetes, and subsequent secondary prevention efforts to thwart or delay transition to diabetes, can reduce morbidity, impaired quality of life, monumental healthcare costs, and mortality rates [1, 2, 8, 9].
(501324) Margaret [Greig]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Top-down response to spatial variation in productivity and bottom-up response to temporal variation in productivity in a long-term study of desert ants
Creators: name: Gibb, Heloise
name: Wardle, Glenda M
name: Greenville, Aaron C
name: Grossman, Blair
name: Dickman, Chris R
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Under the Ecosystem Exploitation Hypothesis ecosystem productivity predicts trophic complexity, but it is unclear if spatial and temporal drivers of productivity have similar impacts. Long-term studies are necessary to capture temporal impacts on trophic structure in variable ecosystems such as deserts. We sampled ants and measured plant resources in the Simpson Desert, central Australia over a 22-year period, during which rainfall varied 10-fold. We sampled dune swales (higher nutrient) and crests (lower nutrient) to account for spatial variation in productivity. We asked how temporal and spatial variation in productivity affects the abundance of ant trophic guilds. Precipitation increased vegetation cover, with the difference more pronounced on dune crests; seeding and flowering also increased with precipitation. Generalist activity increased over time, irrespective of productivity. Predators were more active in more productive (swale) habitat, i.e. spatial impacts of productivity were greatest at the highest trophic level. By contrast, herbivores (seed harvesters and sugar feeders) increased with long-term rainfall; seed harvesters also increased as seeding increased. Temporal impacts of productivity were therefore greatest for low trophic levels. Whether productivity variation leads to top-down or bottom-up structured ecosystems thus depends on the scale and dimension (spatial or temporal) of productivity.
Additional file 15 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 15 Homologs of gene models from Fol4287 chromosome 14 in Foa race 4 and FociGL306
(501318) Harvey B[linn] Strait
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501320) George Greig
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Systematic Review of Fear Learning in Adolescence
Creators: name: Fielmann, Sophie Luise
name: Blakemore, Sarah-Jayne
name: Lee, Daryl Jia Yi
name: Yining Zhang
name: Towner, Emily
Publisher: name: Open Science Framework
Year: 2021
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Developmental Psychology
subject: adolescence
subject: psychology
subject: fear extinction
subject: development
subject: fear learning
subject: adolescent
subject: fear extinction retention

description: Systematic review of threat learning in adolescence
(501321) Harry [John] jr Greig
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 3 of Genomic differences between the new Fusarium oxysporum f. sp. apii (Foa) race 4 on celery, the less virulent Foa races 2 and 3, and the avirulent on celery f. sp. coriandrii
Creators: name: Henry, Peter
name: Kaur, Sukhwinder
name: Pham, Quyen Anh Tran
name: Barakat, Radwan
name: Brinker, Samuel
name: Haensel, Hannah
name: Daugovish, Oleg
name: Epstein, Lynn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3 Virulence of F. oxysporum f. sp. apii and f. sp. coriandrii in celery and coriander
Made You Look: Do Video Thumbnails with Portraits Attract and Hold Users’ Attention?
Creators: name: Mendenhall, Megan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021
Subjects: Interviews
Eye tracking
Streaming video
Interactive multimedia

description: This qualitative pilot study investigates if video thumbnail designs with portraits attract users’ attention faster and hold their attention longer than thumbnail designs without portraits during information-seeking tasks. The study also investigates if users perceive content represented by thumbnail designs with portraits as more trustworthy than content represented by designs without portraits. Additionally, the study asks if, during information-seeking tasks, users show a bias toward engaging with content represented by designs with portraits over designs without portraits. The study used pre-and post-surveys, eye-tracking data, and retro-active think-a-loud interviews to examine these questions. The findings suggest that designs with portraits do not draw users’ attention faster than designs without portraits. However, designs with portraits hold users’ attention longer than designs without portraits only in some information-seeking tasks; for other tasks, designs without portraits hold users’ attention longer than those with portraits. Findings also suggest that some users rely on thumbnail designs as a secondary source of information when assessing the trustworthiness of the video content. Additionally, the findings suggest that during search scenarios when users value information from a source belonging to a specific group or identity, users perceived designs with portraits of sources belonging to the desired group or identity as more trustworthy than thumbnail designs without portraits or designs with portraits of sources from other groups or identities.  The findings also suggest that users are not bias toward engaging with content represented by thumbnail designs with portraits over designs without portraits during information-seeking tasks. Furthermore, the findings suggest that users use thumbnail designs as secondary sources of information to assist with determining the style or tone of video content.
(501317) Jessie [Jessamine J.] [Isabelle] Maskiell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Principles and Metrics for Evaluating Oregon’s Drug Decriminalization Measure: Centering the Voices of People Who Use Drugs
Creators: name: Jules Netherland
name: Ricky Bluthenthal
name: Alex H. Kral
name: Theshia Nadoo
name: Riona Morgan
name: Micheal Gilbert
name: Corey Davis
name: Nabarun Dasgupta
name: Haven Wheelock
name: Danielle Ompad
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: Public health

description: Objective: To develop principles for how to evaluate Measure 110 and a set of meaningful metrics for effectively determining the outcomes of Measure 110
Magnetoimpedance effect at the high frequency range for the thin film geometry: Numerical calculation and experiment
Creators: name: Corrêa, M. A.
name: Bohn, F.
name: da Silva, R. B.
name: Sommer, R. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The magnetoimpedance effect is a versatile tool to investigate ferromagnetic materials, revealing aspects on the fundamental physics associated to magnetization dynamics, broadband magnetic properties, important issues for current and emerging technological applications for magnetic sensors, as well as insights on ferromagnetic resonance effect at non-saturated magnetic states. Here, we perform a theoretical and experimental investigation of the magnetoimpedance effect for the thin film geometry in a wide frequency range. We calculate the longitudinal magnetoimpedance for single layered, multilayered or exchange biased systems from an approach that considers a magnetic permeability model for planar geometry and the appropriate magnetic free energy density for each structure. From numerical calculations and experimental results found in literature, we analyze the magnetoimpedance behavior, and discuss the main features and advantages of each structure. To test the robustness of the approach, we directly compare theoretical results with experimental magnetoimpedance measurements obtained in a wide range of frequencies for an exchange biased multilayered film. Thus, we provide experimental evidence to confirm the validity of the theoretical approach employed to describe the magnetoimpedance in ferromagnetic films, revealed by the good agreement between numerical calculations and experimental results.
description: 10 figures