cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A geometric entropy detecting the Erdös-Rényi phase transition
Creators: name: Franzosi, Roberto
name: Felice, Domenico
name: Mancini, Stefano
name: Pettini, Marco
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We propose a method to associate a differentiable Riemannian manifold to a generic many degrees of freedom discrete system which is not described by a Hamiltonian function. Then, in analogy with classical Statistical Mechanics, we introduce an entropy as the logarithm of the volume of the manifold. The geometric entropy so defined is able to detect a paradigmatic phase transition occurring in random graphs theory: the appearance of the `giant component' according to the Erdös-Rényi theorem.
description: 11 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1410.5459
On the tip of the pen
Creators: name: Cai, Zhenguang
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Linguistics
subject: FOS: Languages and literature
subject: Cognitive Psychology
subject: Psycholinguistics and Neurolinguistics
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This is a repository of experimenal data and scripts for the following paper: Huang, S., Lin, W., Xu, M., Wang, R., & Cai, Z.G. (in press). On the tip of the pen: Effects of character-level lexical variables and handwriter-level individual differences on orthographic retrieval difficulties in Chinese handwriting. Quarterly Journal of Experimental Psychology.
Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice
Creators: name: Bultman, Scott J.
name: Kusewitt, Donna F.
name: Doerstling, Steven S.
name: Ford, Nikki A.
name: Khatib, Subreen A.
name: Dunlap, Sarah M.
name: Rossi, Emily L.
name: Brown, Powel H.
name: Bowers, Laura W.
name: Estecio, Marcos R.
name: Hursting, Stephen D.
name: DeGraffenried, Linda A.
name: Holley, Darcy
name: Smith, Laura A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The association between obesity and breast cancer risk and prognosis is well established in ER-positive disease but less clear in HER2-positive disease. Here, we report preclinical evidence suggesting weight maintenance through calorie restriction may limit risk of HER2-positive breast cancer. In female MMTV-HER2/neu transgenic mice, we found that ERα and ERβ expression, mammary tumorigenesis and survival are energy balance-dependent in association with epigenetic reprogramming. Mice were randomized to receive a calorie restriction (CR), overweight (OW)-inducing, or diet-induced obesity (DIO) regimen (n = 27/group). Subsets of mice (n = 4/group/time point) were euthanized after 1, 3 and 5 months to characterize diet-dependent metabolic, transcriptional, and epigenetic perturbations. Remaining mice were followed up to 22 months. Relative to the OW and DIO regimens, CR decreased body weight, adiposity, and serum metabolic hormones as expected, and also elicited an increase in mammary ERα and ERβ expression. Increased DNA methylation accompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC-binding factor (CTCF) of ESR1 and ESR2, consistent with sustained transcriptional activation of ERα and ERβ. Mammary expression of the DNA methylation enzyme DNMT1 was stable in CR mice but increased over time in OW and DIO mice, suggesting CR obviates epigenetic alterations concurrent with chronic excess energy intake. In the survival study, CR elicited a significant suppression in spontaneous mammary tumorigenesis. Overall, our findings suggest a mechanistic rationale to prevent or reverse excess body weight as a strategy to reduce HER2-positive breast cancer risk.
title: Look at what popped up!
Creators: name: Torres, Lígia
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Kidney
subject: Urinary Tract / Bladder
subject: Genital / Reproductive system female
subject: CT
subject: Ultrasound
subject: Computer Applications-Detection, diagnosis
subject: Education
subject: Fistula
subject: Abscess
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the different etiologies of gas in the urinary tract To illustrate the imaging features of these conditions using ultrasound and computed tomography To discuss the management of these lesions and provide tips to avoid potential diagnostic...
title: Voiding urosonography with second generation contrast agent or voiding cystourethrography
Creators: name: Tercero Azorín, Maria Isabel
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Paediatric
subject: Urinary Tract / Bladder
subject: Ultrasound
subject: Contrast agent-other
subject: Dilatation
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The objective was to evaluate the utility of the voiding urosonography (VU) with second-generation contrast compare to the voiding cystourethrography (VCUG) in the screening and follow-up of vesicourethral reflux (VUR) and in the urethral...
Prescribed (Over)Optimism Study 3
Creators: name: Miller, Jane
name: Park, Inkyung
name: Smith, Andrew
name: Windschitl, Paul
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: accuracy
subject: bias
subject: estimation
subject: forecasting
subject: judgments
subject: optimism
subject: prediction

description: Past work has suggested that people prescribe optimism—believing it is better to be optimistic, instead of accurate or pessimistic, about uncertain future events. Here, we identified and addressed an important ambiguity about whether those findings reflect an endorsement of biased beliefs—i.e., whether people prescribe likelihood estimates that reflect overoptimism. In three studies, participants (total N = 663 U.S. university students) read scenarios about protagonists facing uncertain events with a desired outcome. Results replicated prescriptions of optimism when using the same solicitations as in past work. However, we found quite different prescriptions when using alternative solicitations that asked about potential bias in likelihood estimations and that did not involve vague terms like “optimistic.” Participants generally prescribed being optimistic, feeling optimistic, and even thinking optimistically about the events, but they did not prescribe overestimating the likelihood of those events.
Disorder-induced light trapping enhanced by pulse collisions in one-dimensional nonlinear photonic crystals
Creators: name: Novitsky, Denis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We use numerical simulations to study interaction of co- and counter-propagating pulses in disordered multilayers with noninstantaneous Kerr nonlinearity. We propose a statistical argument for existence of the disorder-induced trapping which implies the dramatic rise of the probability of realization with low output energy in the structure with a certain level of disorder. This effect is much more pronounced in the case of two interacting pulses than in the single-pulse regime and does not occur in the strictly ordered system at the same intensity of the pulses. Therefore it cannot be explained simply as a result of increase in strength of nonlinear light-matter interaction.
description: 7 pages, 9 figures, 2 tables
Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer
Creators: name: Carrasco, Eva
name: Perou, Charles M.
name: Rojo, Federico
name: Guerrero-Zotano, Ángel
name: Albanell, Joan
name: Martinello, Rosella
name: Blancas, Isabel
name: Adamo, Vincenzo
name: Prat, Aleix
name: López-Muniz, José I Chacón
name: Nucíforo, Paolo
name: Vidal, María
name: Gasión, Octavio Burgués
name: De Dueñas, Eduardo Martínez
name: Caballero, Rosalía
name: Antolín, Silvia
name: Paré, Laia
name: Cortés, Javier
name: Adamo, Barbara
name: García-Recio, Susana
name: Lluch, Ana
name: Muñoz, Montserrat
name: Peg, Vicente
name: Galván, Patricia
name: Cejalvo, Juan M.
name: Pérez, Ramon M.
name: Gomis, Roger R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Biological changes that occur during metastatic progression of breast cancer are still incompletely characterized. In this study, we compared intrinsic molecular subtypes and gene expression in 123 paired primary and metastatic tissues from breast cancer patients. Intrinsic subtype was identified using a PAM50 classifier and χ 2 tests determined the differences in variable distribution. The rate of subtype conversion was 0% in basal-like tumors, 23.1% in HER2-enriched (HER2-E) tumors, 30.0% in luminal B tumors, and 55.3% in luminal A tumors. In 40.2% of cases, luminal A tumors converted to luminal B tumors, whereas in 14.3% of cases luminal A and B tumors converted to HER2-E tumors. We identified 47 genes that were expressed differentially in metastatic versus primary disease. Metastatic tumors were enriched for proliferation-related and migration-related genes and diminished for luminal-related genes. Expression of proliferation-related genes were better at predicting overall survival in metastatic disease (OSmet) when analyzed in metastatic tissue rather than primary tissue. In contrast, a basal-like gene expression signature was better at predicting OSmet in primary disease compared with metastatic tissue. We observed correlations between time to tumor relapse and the magnitude of changes of proliferation, luminal B, or HER2-E signatures in metastatic versus primary disease. Although the intrinsic subtype was largely maintained during metastatic progression, luminal/HER2-negative tumors acquired a luminal B or HER2-E profile during metastatic progression, likely reflecting tumor evolution or acquisition of estrogen independence. Overall, our analysis revealed the value of stratifying gene expression by both cancer subtype and tissue type, providing clinicians more refined tools to evaluate prognosis and treatment. Cancer Res; 77(9); 1-9. ©2017 AACR.
Hexen und Birnen? Befunde einer vergleichenden Inhaltsanalyse
Creators: name: Müller, Andreas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 900 Geschichte und Geografie: 940 Geschichte Europas: 943 Geschichte Geschichte Mitteleuropas; Deutschlands

description: Das Poster zeigt den systematischen Vergleich von zwei Textkorpora mittels qualitativer Inhaltsanalyse. Für die Untersuchung von Hexenprozessakten aus Rostock 1584 und Hainburg 1617/18 wurde die Software MAXQDA eingesetzt, um inhaltliche wie strukturelle Unterschiede aufzuzeigen. Das Poster wurde auf dem Berliner Methodentreffen (BMT) im Juli 2017 präsentiert.
title: Radiofrequency ablation of renal cell tumours: A single –centre experience
Creators: name: Koundouraki, Antonia
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional non-vascular
subject: Kidney
subject: Oncology
subject: CT
subject: Percutaneous
subject: Ultrasound
subject: Ablation procedures
subject: Multidisciplinary cancer care

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Percutaneous radiofrequency ablation (RFA) is an established technique for the treatment of small renal tumours [1-2] . The aim of this study is to review our experience of image-guided (RFA) of renal tumours in a single tertiary referral...
title: Sonoelastography (SEL) in plantar aponeurosis with strain ratio (SR) measurements in two different planes: findings in healthy subjects
Creators: name: Abd Ellah, Mohamed
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal soft tissue
subject: Elastography
subject: Diagnostic procedure

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Planter fasciitis (PF) is the most common cause of heel pain. [1] Increased age had been claimed in a previous report to be one of the factors associated with chronic plantar heel pain. [2] Age related changes of tendons and its elastic properties...
Prescribed (Over)Optimism Study 1
Creators: name: Miller, Jane
name: Park, Inkyung
name: Smith, Andrew
name: Windschitl, Paul
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: accuracy
subject: bias
subject: estimation
subject: forecasting
subject: judgments
subject: optimism
subject: prediction

description: Past work has suggested that people prescribe optimism—believing it is better to be optimistic, instead of accurate or pessimistic, about uncertain future events. Here, we identified and addressed an important ambiguity about whether those findings reflect an endorsement of biased beliefs—i.e., whether people prescribe likelihood estimates that reflect overoptimism. In three studies, participants (total N = 663 U.S. university students) read scenarios about protagonists facing uncertain events with a desired outcome. Results replicated prescriptions of optimism when using the same solicitations as in past work. However, we found quite different prescriptions when using alternative solicitations that asked about potential bias in likelihood estimations and that did not involve vague terms like “optimistic.” Participants generally prescribed being optimistic, feeling optimistic, and even thinking optimistically about the events, but they did not prescribe overestimating the likelihood of those events.
Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors
Creators: name: Wang, Yuhua
name: Miao, Lei
name: Huang, Leaf
name: Hu, Shihao
name: Lin, C. Michael
name: Liu, Qi
name: Kim, William Y.
name: Yin, Weiyan
name: Liu, Lina
name: Luo, Cong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The off-target distribution of anticancer nanoparticles to fibroblasts creates a barrier to the effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle detriment might be exploited to target the expression of secreted cytotoxic proteins from tumor-associated fibroblasts (TAF) as an anticancer strategy. In addressing this hypothesis, plasmids encoding the secretable TNF-related factor sTRAIL were loaded into lipid-coated protamine DNA complexes and administered by infusion in a murine xenograft model of human desmoplastic bladder carcinoma. Three doses were sufficient to generate approximately 70% of TAFs as sTRAIL-producing cells. sTRAIL triggered apoptosis in tumor cell nests adjacent to TAFs. Furthermore, it reverted residual fibroblasts to a quiescent state due to insufficient activation, further compromising tumor growth and remodeling the microenvironment to favor second-wave nanotherapy. We confirmed the efficacy of this strategy in an orthotopic xenograft model of human pancreatic cancer, where the desmoplastic stroma is well known to be a major barrier to the delivery of therapeutic nanoparticles. Collectively, our results offer a proof of concept for the use of nanoparticles to modify TAFs as an effective strategy to treat desmoplastic cancers. Cancer Res; 77(3); 719-31. ©2016 AACR.
title: Unexplained chronic cough (UCC) in children: can chest computed tomography (CCT) help in making a diagnosis? What about radiation exposure?
Creators: name: Cellina, Michaela
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Paediatric
subject: Thorax
subject: Radioprotection / Radiation dose
subject: CT
subject: Dosimetry
subject: Chronic obstructive airways disease

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Definition of chronic cough: Cough is an essential protective and defensive act, is the most effective mechanism for clearing the upper airways and is considered an innate built-in defense mechanism. Different timing has been reported to define...
Prescribed (Over)Optimism Study 2
Creators: name: Miller, Jane
name: Park, Inkyung
name: Smith, Andrew
name: Windschitl, Paul
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: accuracy
subject: bias
subject: estimation
subject: forecasting
subject: judgments
subject: optimism
subject: prediction

description: Past work has suggested that people prescribe optimism—believing it is better to be optimistic, instead of accurate or pessimistic, about uncertain future events. Here, we identified and addressed an important ambiguity about whether those findings reflect an endorsement of biased beliefs—i.e., whether people prescribe likelihood estimates that reflect overoptimism. In three studies, participants (total N = 663 U.S. university students) read scenarios about protagonists facing uncertain events with a desired outcome. Results replicated prescriptions of optimism when using the same solicitations as in past work. However, we found quite different prescriptions when using alternative solicitations that asked about potential bias in likelihood estimations and that did not involve vague terms like “optimistic.” Participants generally prescribed being optimistic, feeling optimistic, and even thinking optimistically about the events, but they did not prescribe overestimating the likelihood of those events.
Improving well-being and survival in the 6-OHDA lesion model of Parkinson´s disease in mice: Literature review and step-by-step protocol
Creators: name: Guillaumin, Adriane
name: Vicek, Bianca
name: Wallén-Mackenzie, Åsa
Publisher: name: Scandinavian Journal of Laboratory Animal Science
Year: 2022

description: Parkinson’s disease (PD) is the most common neurodegenerative motor disorder and primarily affects movement control but also a range of non-motor functions. With unknown etiology and lack of cure, much research is dedicated to unravel pathological mechanisms and improve clinical prospects for symptom alleviation, prevention and treatment. To achieve these goals, animal models intended to represent symptoms similar to those observed in the complex clinical display of PD play a key role. It is important to bear in mind that, in any studies with laboratory animals, it is crucial to take the 3Rs principle (Refine, Reduce, Replace) into account. The main pathology of PD includes degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). The 6-hydroxydopamine (6-OHDA) lesion model, in which dopaminergic neurons are chemically destroyed, is often favored as a laboratory model of PD in both rodents and primates. However, while reproducing several features of clinical PD, mice exposed to 6-OHDA frequently experience systemic dysfunction causing premature death. To avoid suffering and unnecessary deaths of laboratory mice, there is a need for improved experimental protocols in accordance with the 3Rs principle. Based on current literature and our own previous experiments, we decided to test the effect of three parameters: 1) reduced dose of the 6-OHDA toxin; 2) daily post-operative care to avoid hypothermia and energy loss; 3) shortened interval from surgical injection of toxin to time of sacrifice. By implementing a 6-OHDA lesion protocol using a lower dose of toxin than commonly seen in the literature alongside careful post-operative care and decreased time post-injection, a fully recovered weight post-surgery and high survival rate was obtained. This was achieved despite full expression of the 6-OHDA-induced locomotor phenotype. A step-by-step protocol was formulated. Validation using histological analysis confirmed toxin-induced degeneration of midbrain dopamine neurons with concomitant loss of dopaminergic projections in the lesioned hemisphere. Notably, while SNc dopamine neurons were drastically reduced, those located in the ventral tegmental area (VTA) were less affected in a medialhigh survival to laterallow survival manner. The Refine and Reduce parameters of the 3Rs principle in experimental animal welfare were specifically addressed which allowed us to improve well-being and survival of mice while maintaining characteristic parkinsonian features in the 6-OHDA lesion model. A table summarizing current literature on the 6-OHDA model in rodents as well as our validated step-by-step experimental protocol is provided.
description: Scandinavian Journal of Laboratory Animal Science, Vol. 48 (2022)
Predictions for Ultra-Deep Radio Counts of Star-Forming Galaxies
Creators: name: Mancuso, Claudia
name: Lapi, Andrea
name: Cai, Zhen-Yi
name: Negrello, Mattia
name: De Zotti, Gianfranco
name: Bressan, Alessandro
name: Bonato, Matteo
name: Perrotta, Francesca
name: Danese, Luigi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have worked out predictions for the radio counts of star-forming galaxies down to nJy levels, along with redshift distributions down to the detection limits of the phase 1 Square Kilometer Array MID telescope (SKA1-MID) and of its precursors. Such predictions were obtained by coupling epoch dependent star formation rate (SFR) functions with relations between SFR and radio (synchrotron and free-free) emission. The SFR functions were derived taking into account both the dust obscured and the unobscured star-formation, by combining far-infrared (FIR), ultra-violet (UV) and H_alpha luminosity functions up to high redshifts. We have also revisited the South Pole Telescope (SPT) counts of dusty galaxies at 95\,GHz performing a detailed analysis of the Spectral Energy Distributions (SEDs). Our results show that the deepest SKA1-MID surveys will detect high-z galaxies with SFRs two orders of magnitude lower compared to Herschel surveys. The highest redshift tails of the distributions at the detection limits of planned SKA1-MID surveys comprise a substantial fraction of strongly lensed galaxies. We predict that a survey down to 0.25 microJy at 1.4 GHz will detect about 1200 strongly lensed galaxies per square degree, at redshifts of up to 10. For about 30% of them the SKA1-MID will detect at least 2 images. The SKA1-MID will thus provide a comprehensive view of the star formation history throughout the re-ionization epoch, unaffected by dust extinction. We have also provided specific predictions for the EMU/ASKAP and MIGHTEE/MeerKAT surveys.
description: 31 pages, 18 figures, 1 table. Accepted by ApJ
Permanent education for health professionals in the care of people with obesity: scoping review protocol
Creators: name: Magalhães, Carolina
name: de Santana, Mônica
name: da Silva, Lígia
name: Martins, Poliana
name: ceccim, ricardo
name: Junior, Gesner
name: PEREIRA, EMILE
name: Santos, Ana
name: Santos, Verena
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Medicine and Health Sciences
subject: Medical Education
subject: permanent education; obesity; health professional

description: The present project investigates the permanent education initiatives of health professionals in the care for people with obesity, understanding that it is a topic of great worldwide relevance and that it can act both in the microsocial field, individualizing the care approach, as well as in the macrosocial, reflecting in the decrease of the propagation of the obesity phenomenon. In this sense, its main objective is to map and summarize all the evidence found in this area, in national and international literature, contributing to re / designing public policies, programs and actions in the field of permanent health education focused on obesity. The following research questions were designed to explore the evidence produced in the literature on continuing education for health professionals in the care of people with obesity : 1. What has been produced in the literature on health professionals' continuing education in care for people with obesity? 2. What are the themes and methodologies used in health professionals' permanent education initiatives in people's care with obesity? 3. How is obesity conceptualized in health professionals' continuing education initiatives in the care of people with obesity? 4. What are the results of permanent education initiatives by health professionals in caring for people with obesity?
KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment
Creators: name: Zeitouni, Daniel
name: Der, Channing J.
name: Pylayeva-Gupta, Yuliya
name: Bryant, Kirsten L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers with a dismal 7% 5-year survival rate and is projected to become the second leading cause of cancer-related deaths by 2020. KRAS is mutated in 95% of PDACs and is a well-validated driver of PDAC growth and maintenance. However, despite comprehensive efforts, an effective anti-RAS drug has yet to reach the clinic. Different paths to inhibiting RAS signaling are currently under investigation in the hope of finding a successful treatment. Recently, direct RAS binding molecules have been discovered, challenging the perception that RAS is an “undruggable” protein. Other strategies currently being pursued take an indirect approach, targeting proteins that facilitate RAS membrane association or downstream effector signaling. Unbiased genetic screens have identified synthetic lethal interactors of mutant RAS. Most recently, metabolic targets in pathways related to glycolytic signaling, glutamine utilization, autophagy, and macropinocytosis are also being explored. Harnessing the patient’s immune system to fight their cancer is an additional exciting route that is being considered. The “best” path to inhibiting KRAS has yet to be determined, with each having promise as well as potential pitfalls. We will summarize the state-of-the-art for each direction, focusing on efforts directed toward the development of therapeutics for pancreatic cancer patients with mutated KRAS.
title: 320-row CT transcatheter aortic valve implantation planning using a single reduced contrast media bolus injection: a prospective study on 50 patients
Creators: name: Ohana, Mickaël
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: Radioprotection / Radiation dose
subject: CT
subject: CT-Angiography
subject: Comparative studies
subject: Technology assessment

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Transcatheter Aortic Valve Implantation (TAVI) is now established as a valid alternative therapeutic procedurefor patients who either have contraindications to open surgery or decline it. Computed Tomography Angiography (CTA) plays an essential role...
title: Anterior tibial translation as a potential indicator of the long-term anterior cruciate ligament reconstruction outcome
Creators: name: Snoj, Ziga
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal joint
subject: MR
subject: Surgery
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Anterior cruciate ligament (ACL) is the primary restraint of anterior tibial translation (ATT) relative to femur [1]. Following ACL injury, most patients have detectable excess knee laxity and may experience instability problems. The aim of anterior...
Targeting the TAM Receptors in Leukemia
Creators: name: Shelton Earp,
name: Minson, Katherine A.
name: Huey, Madeline G.
name: Graham, Douglas K.
name: Deryckere, Deborah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Targeted inhibition of members of the TAM (TYRO-3, AXL, MERTK) family of receptor tyrosine kinases has recently been investigated as a novel strategy for treatment of hematologic malignancies. The physiologic functions of the TAM receptors in innate immune control, natural killer (NK) cell differentiation, efferocytosis, clearance of apoptotic debris, and hemostasis have previously been described and more recent data implicate TAM kinases as important regulators of erythropoiesis and megakaryopoiesis. The TAM receptors are aberrantly or ectopically expressed in many hematologic malignancies including acute myeloid leukemia, B- and T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma. TAM receptors contribute to leukemic phenotypes through activation of pro-survival signaling pathways and interplay with other oncogenic proteins such as FLT3, LYN, and FGFR3. The TAM receptors also contribute to resistance to both cytotoxic chemotherapeutics and targeted agents, making them attractive therapeutic targets. A number of translational strategies for TAM inhibition are in development, including small molecule inhibitors, ligand traps, and monoclonal antibodies. Emerging areas of research include modulation of TAM receptors to enhance anti-tumor immunity, potential roles for TYRO-3 in leukemogenesis, and the function of the bone marrow microenvironment in mediating resistance to TAM inhibition.
Semi-Spectral Method for the Wigner equation
Creators: name: Furtmaier, Oliver
name: Succi, Sauro
name: Mendoza, Miller
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Analysis of PDEs (math.AP)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: G.1.8; J.2
subject: 81-08, 35L03, 65M70, 65M12

description: We propose a numerical method to solve the Wigner equation in quantum systems of spinless, non-relativistic particles. The method uses a spectral decomposition into $L^2(\mathbb{R}^d)$ basis functions in momentum-space to obtain a system of first-order advection-reaction equations. The resulting equations are solved by splitting the reaction and advection steps so as to allow the combination of numerical techniques from quantum mechanics and computational fluid dynamics by identifying the skew-hermitian reaction matrix as a generator of unitary rotations. The method is validated for the case of particles subject to a one-dimensional (an-)harmonic potential using finite-differences for the advection part. Thereby, we verify the second order of convergence and observe non-classical behavior in the evolution of the Wigner function.
description: 16 pages, 27 figures
title: Early cerebral changes in asymptomatic HCV-positive patients as related to the liver histology activity index: is there a biologic link between liver disease and cerebral dysfunction?
Creators: name: Bladowska, Joanna
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: MR-Diffusion/Perfusion
subject: MR-Spectroscopy
subject: Diagnostic procedure
subject: Infection

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Numerous studies have documented that the hepatitis C virus (HCV) can invade the central nervous system (CNS), which was supported by detection of HCV specific transcripts and proteins in post-mortem brains of HCV-infected patients [1-3]. It has...
Logarithmic corrected Polynomial $f(R)$ inflation mimicking a cosmological constant
Creators: name: Sadeghi, J.
name: Pourhassan, B.
name: Kubeka, A. S.
name: Rostami, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we consider an inflationary model of $f(R)$ gravity with polynomial form plus logarithmic term. We calculate some cosmological parameters and compare our results with the Plank 2015 data. We find that presence of both logarithmic and polynomial corrections are necessary to yield slow-roll condition. Also, we study critical points and stability of the model to find that it is a viable model.
description: 15 pages, 9 figures
title: The effect of smoking status on variation tendency of pulmonary vascular in asymptomatic adults as determined by quantitative CT measurement: a four-year longitudinal study
Creators: name: Deng, Lei
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Computer applications
subject: Lung
subject: CT-Quantitative
subject: Computer Applications-Detection, diagnosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Pulmonary vascular alteration is a key contributor to increased pulmonary vascular resistance in chronic obstructive pulmonary disease (COPD) and can be observed in histological study. Our colleague reported that decline in pulmonary vessels in COPD...
Methods of analysing patterns of multimorbidity using network analysis: a scoping review
Creators: name: Jones, Imogen
name: Neil, Amanda
name: Charleston, Michael
name: Cocker, Fiona
name: Jose, Matthew
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: comorbidity
subject: multimorbidity
subject: multiple chronic conditions
subject: network analysis
subject: social network analysis

description: The purpose of this review is to summarise the techniques used in published peer-reviewed literature on network analysis in multimorbidity. There is currently no recommended approach in calculating and displaying networks of chronic health conditions. It is the aim of this paper to outline the use of network analysis in multimorbidity to inform development of a standard methodology.
Androgen Receptor-Dependent and -Independent Mechanisms Involved in Prostate Cancer Therapy Resistance
Creators: name: Crona, Daniel J.
name: Whang, Young E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Despite the initial efficacy of androgen deprivation in prostate cancer, virtually all patients progress to castration-resistant prostate cancer (CRPC). Androgen receptor (AR) signaling is critically required for CRPC. A new generation of medications targeting AR, such as abiraterone and enzalutamide, has improved survival of metastatic CRPC (mCRPC) patients. However, a significant proportion of patients presents with primary resistance to these agents, and in the remainder, secondary resistance will invariably develop, which makes mCRPC the lethal form of the disease. Mechanisms underlying progression to mCRPC and treatment resistance are extremely complex. AR-dependent resistance mechanisms include AR amplification, AR point mutations, expression of constitutively active AR splice variants, and altered intratumoral androgen biosynthesis. AR-independent resistance mechanisms include glucocorticoid receptor activation, immune-mediated resistance, and neuroendocrine differentiation. The development of novel agents, such as seviteronel, apalutamide, and EPI-001/EPI-506, as well as the identification and validation of novel predictive biomarkers of resistance, may lead to improved therapeutics for mCRPC patients.
title: Dynamic CT cardiac perfusion protocol at 70 kV: impact on radiation and contrast agent dose
Creators: name: Buls, Nico
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiac
subject: Animal (veterinary) studies
subject: Contrast agents
subject: CT-Angiography
subject: CT-Quantitative
subject: Experimental investigations
subject: Imaging sequences
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Wide detector CT systems can perform repeated acquisitions over a constant patient volumewithout table movement, allowing dynamic CT scanning. For the detection of coronary artery disease (CAD), it has been reported that dynamic imagingof myocardial...
Gelatin/carboxymethyl cellulose mucoadhesive films with lysozyme: Development and characterization
Creators: name: Tkach, Vasiliy
name: Romanovska, Irina
name: Ovsepyan, Ani
name: Muratov, Eugene
name: Dekina, Svetlana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The goal of our study is to develop and characterize mucoadhesive films with entrapped lysozyme based on gelatin/sodium carboxymethyl cellulose as perspective antimicrobial preparation. Lysozyme in mucoadhesive films retains more than 95 % of its initial activity for 3 years of storage. Different physical-chemical and biochemical characteristics of entrapped enzyme were evaluated, such as film thickness, weight, time of dissolution in water, bioadhesive force, in vitro lysozyme release, pH- and thermoprofiles of hydrolytic activity, effect of γ-sterilization, etc. We have shown that gelatin/sodium carboxymethyl cellulose films have adhesive force on the level of 4380 Pa. Scanning electron microscopy images shows the relative uniformity of the gelatin surface with entrapped lysozyme. Mucoadhesive films with lysozyme have 100% bactericidal effect on the test strain, Staphylococcus aureus ATCC 25923 F - 49 and thus could be considered as a perspective antimicrobial preparation.
title: Which additional technique has a better diagnostic performance: digital breast tomosynthesis or ultrasound? A lesion-based study
Creators: name: Madrid, José Miguel
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Mammography
subject: Ultrasound
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: INTRODUCTION Authors declare no conflicts of interest to disclose. Breast cancer is the most common malignant tumour in women and the most common cause of death due to cancer in women [1]. Mammography is worldwide used as the technique of choice to...
Three-Way Dictator Game
Creators: name: Kelly, John
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: A pre-registration for a study using a three-way dictator game. Participants will either be reminded to think about God or not, and have the choice to donate to an ingroup Christian and outgroup Atheist recipient.
A physics based model of gate tunable metal-graphene contact resistance benchmarked against experimental data
Creators: name: Chaves, Ferney A.
name: Jiménez, David
name: Sagade, Abhay A.
name: Kim, Wonjae
name: Riikonen, Juha
name: Lipsanen, Harri
name: Neumaier, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The metal-graphene contact resistance is a technological bottleneck for the realization of viable graphene based electronics. We report a useful model to find the gate tunable components of this resistance determined by the sequential tunneling of carriers between the 3D-metal and 2D-graphene underneath followed by Klein tunneling to the graphene in the channel. This model quantifies the intrinsic factors that control that resistance, including the effect of unintended chemical doping. Our results agree with experimental results for several metals.
description: 24 pages, 12 Figures
title: Internal audit of the adequacy of MRI imaging protocol in patients studied because of headache. A multicenter MR imaging group study
Creators: name: Martínez Barbero, José Pablo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Management
subject: Neuroradiology brain
subject: MR
subject: RIS
subject: Audit and standards
subject: Patterns of Care
subject: Workforce

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To describe our procotol imputationflow in a multi - center structure, in anorgan system organization. To assess the adequacy of the protocol chosen for the studiy of headache in cranial MRI studies, depending on clinical data, and pre-established...
A case–control analysis of smoking and breast cancer in African American women: findings from the AMBER Consortium
Creators: name: Viscidi, Emma
name: Bandera, Elisa V.
name: Palmer, Julie R.
name: Ambrosone, Christine B.
name: Rosenberg, Lynn
name: Kolonel, Laurence N.
name: Bethea, Traci N.
name: Troester, Melissa A.
name: Haiman, Christopher A.
name: Park, Song-Yi
name: Olshan, Andrew F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast cancer risk by menopause and hormone receptor status [estrogen receptor-positive (ER+), ER-negative (ER−) and triple-negative (ER−, PR−, HER2−)]. The study included 5791 African American women with breast cancer and 17376 African American controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in multivariable logistic regression analysis with adjustment for study and risk factors. Results differed by menopausal status. Among postmenopausal women, positive associations were observed for long duration and greater pack-years of smoking: relative to never smoking, fully adjusted ORs were 1.14 (95% CI: 1.03–1.26) for duration ≥20 years and 1.16 (95% CI: 1.01–1.33) for ≥20 pack-years. By contrast, inverse associations were observed among premenopausal women, with ORs of 0.80 (95% CI: 0.68–95) for current smoking and 0.81 (95% CI: 0.69–0.96) for former smoking, without trends by duration. Associations among postmenopausal women were somewhat stronger for ER+ breast cancer. The findings suggest that the relation of cigarette smoking to breast cancer risk in African American women may vary by menopausal status and breast cancer subtype.
Task shifting between physicians and nurses in acute care hospitals: cross-sectional study in nine countries
Creators: name: Maier, Claudia B.
name: Köppen, Julia
name: Busse, Reinhard
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 610 Medizin und Gesundheit
subject: health professionals
subject: physicians
subject: task shifting
subject: advanced practice nursing
subject: hospitals
subject: scope-of-practice
subject: clinical practice
subject: breast cancer
subject: acute myocardial infarction
subject: nurses

description: Background Countries vary in the extent to which reforms have been implemented expanding nurses’ Scopes-of-Practice (SoP). There is limited cross-country research if and how reforms affect clinical practice, particularly in hospitals. This study analyses health professionals’ perceptions of role change and of task shifting between the medical and nursing professions in nine European countries. Methods Cross-sectional design with surveys completed by 1716 health professionals treating patients with breast cancer (BC) and acute myocardial infarction (AMI) in 161 hospitals across nine countries. Descriptive and bivariate analysis on self-reported staff role changes and levels of independence (with/without physician oversight) by two country groups, with major SoP reforms implemented between 2010 and 2015 (Netherlands, England, Scotland) and without (Czech Republic, Germany, Italy, Norway, Poland, Turkey). Participation in ‘medical tasks’ was identified using two methods, a data-driven and a conceptual approach. Individual task-related analyses were performed for the medical and nursing professions, and Advanced Practice Nurses/Specialist Nurses (APN/SN). Results Health professionals from the Netherlands, England and Scotland more frequently reported changes to staff roles over this time period vs. the other six countries (BC 74.0% vs. 38.7%, p
Energy landscapes for the self-assembly of supramolecular polyhedra
Creators: name: Russell, Emily R.
name: Menon, Govind
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences
subject: 52B05, 70B15, 92C40, 92E10

description: We develop a mathematical model for the energy landscape of polyhedral supramolecular cages recently synthesized by self-assembly [Sun et al., Science 2010]. Our model includes two essential features of the experiment: (i) geometry of the organic ligands and metallic ions; and (ii) combinatorics. The molecular geometry is used to introduce an energy that favors square-planar vertices (modeling $\mathrm{Pd}^{2+}$ ions) and bent edges with one of two preferred opening angles (modeling boomerang-shaped ligands of two types). The combinatorics of the model involve $2$-colorings of edges of polyhedra with $4$-valent vertices. The set of such $2$-colorings, quotiented by the octahedral symmetry group, has a natural graph structure, and is called the combinatorial configuration space. The energy landscape of our model is the energy of each state in the combinatorial configuration space. The challenge in the computation of the energy landscape is a combinatorial explosion in the number of $2$-colorings of edges. We describe sampling methods based on the symmetries of the configurations and connectivity of the configuration graph. When the two preferred opening angles encompass the geometrically ideal angle, the energy landscape exhibits a very low-energy minimum for the most symmetric configuration at equal mixing of the two angles, even when the average opening angle does not match the ideal angle.