title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÑ ÑÑÑÐµÐºÑÐ¾Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐµÐ»ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð±Ð»Ð¾ÐºÐ°ÑÐ¾ÑÐ° Ð½Ð°ÑÑÐ¸Ð¹-ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²Ð¾Ð³Ð¾ Ð¾Ð±Ð¼ÐµÐ½Ð½Ð¸ÐºÐ° KB-R7943 ÐºÐ°Ðº Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð±Ð¾Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ñ ÐºÑÑÑ Ñ Ð²ÑÐ·Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ°Ñ Ð°ÑÐ½ÑÐ¼ Ð´Ð¸Ð°Ð±ÐµÑÐ¾Ð¼ 1 ÑÐ¸Ð¿Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Investigation of the side effects of the sodium-calcium exchanger blocker KB-R7943 as an anti-pain drug in rats with induced type 1 diabetes mellitus
Creators: name: ÐÐ°ÑÐ¸ÐµÐ²Ð°, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: KB-R7943
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Ð½Ð°ÑÑÐ¸Ð¹-ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²ÑÐ¹ Ð¾Ð±Ð¼ÐµÐ½Ð½Ð¸Ðº
Ð´Ð¸Ð°Ð±ÐµÑÐ¸ÑÐµÑÐºÐ°Ñ Ð½ÐµÐ¹ÑÐ¾Ð¿Ð°ÑÐ¸Ñ
Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÐ¹ ÑÑÑÐµÐºÑ
Ð¼Ð¾Ð·Ð³
ÑÐµÑÐ´ÑÐµ
ÐºÑÑÑÐ°
Ð­ÐÐ
amitriptyline
sodium-calcium exchanger
diabetic neuropathy
side effect
brain
heart
rat
ECG

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÑ ÑÑÑÐµÐºÑÐ¾Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐµÐ»ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð±Ð»Ð¾ÐºÐ°ÑÐ¾ÑÐ° Ð½Ð°ÑÑÐ¸Ð¹-ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²Ð¾Ð³Ð¾ Ð¾Ð±Ð¼ÐµÐ½Ð½Ð¸ÐºÐ° KB-R7943 ÐºÐ°Ðº Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð±Ð¾Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ñ ÐºÑÑÑ Ñ Ð²ÑÐ·Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ°ÑÐ°ÑÐ½ÑÐ¼ Ð´Ð¸Ð°Ð±ÐµÑÐ¾Ð¼ 1-Ð³Ð¾ ÑÐ¸Ð¿Ð°Â». ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÑ ÑÑÑÐµÐºÑÐ¾Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐµÐ»ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð±Ð»Ð¾ÐºÐ°ÑÐ¾ÑÐ° Ð½Ð°ÑÑÐ¸Ð¹-ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²Ð¾Ð³Ð¾ Ð¾Ð±Ð¼ÐµÐ½Ð½Ð¸ÐºÐ° KB-R7943 ÐºÐ°Ðº Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð±Ð¾Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ñ ÐºÑÑÑ Ñ Ð²ÑÐ·Ð²Ð°Ð½Ð½ÑÐ¼ ÑÑÑÐµÐ¿ÑÐ¾Ð·Ð¾ÑÐ¾ÑÐ¸Ð½Ð¾Ð¼ ÑÐ°ÑÐ°ÑÐ½ÑÐ¼ Ð´Ð¸Ð°Ð±ÐµÑÐ¾Ð¼ 1-Ð³Ð¾ ÑÐ¸Ð¿Ð°. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ KB-R7943 Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð¿ÑÐ¾Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ðµ KB-R7943 ÑÐµÑÐµÐ· Ð³ÐµÐ¼Ð°ÑÐ¾ÑÐ½ÑÐµÑÐ°Ð»Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð±Ð°ÑÑÐµÑ Ð¸ ÐµÐ³Ð¾ Ð´ÐµÐ¿Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð² ÑÐºÐ°Ð½ÑÑ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð¸ ÑÐµÑÐ´ÑÐ°. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð­ÐÐ Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð¾ÑÑÑÑÑÑÐ²Ð¸Ðµ Ð½ÐµÐ³Ð°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ KB-R7943 Ð½Ð° ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ ÑÐµÑÐ´ÐµÑÐ½Ð¾-ÑÐ¾ÑÑÐ´Ð¸ÑÑÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½ÑÑ ÐºÑÑÑ Ð¸ ÐºÑÑÑ Ñ ÑÐ°ÑÐ°ÑÐ½ÑÐ¼ Ð´Ð¸Ð°Ð±ÐµÑÐ¾Ð¼ 1-Ð³Ð¾ ÑÐ¸Ð¿Ð°. Ð ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð² Ð¾ÑÐºÑÑÑÐ¾Ð¼ Ð¿Ð¾Ð»Ðµ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ (Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»ÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¸ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¸ ÑÑÐµÐ²Ð¾Ð¶Ð½Ð¾ÑÑÐ¸) ÐºÑÑÑ Ð½Ðµ Ð¸Ð·Ð¼ÐµÐ½ÑÐ»Ð¾ÑÑ Ð¿Ð¾ÑÐ»Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ KB-R7943. ÐÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÐ¾Ð²Ð½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð° Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾Ð³Ð¾ Ð½Ð°ÑÑÐ¸ÐµÐ²Ð¾Ð³Ð¾ ÐºÐ°Ð½Ð°Ð»Ð° Nav1.7 (SCN9A), Î±2Î´-1 ÑÑÐ±ÑÐµÐ´Ð¸Ð½Ð¸ÑÑ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼ÑÑ ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²ÑÑ ÐºÐ°Ð½Ð°Ð»Ð¾Ð² Ð¢-ÑÐ¸Ð¿Ð° (CACNA2D1), Bax Ð¸ Bcl-2, Ð·Ð°Ð´ÐµÐ¹ÑÑÐ²Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð² Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð´Ð¸Ð°Ð±ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð½ÐµÐ¹ÑÐ¾Ð¿Ð°ÑÐ¸Ð¸, Ð² ÑÐºÐ°Ð½ÑÑ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð° Ð¸ Ð³Ð¸Ð¿Ð¾ÑÐ°Ð»Ð°Ð¼ÑÑÐ°.
description: This work is devoted to the investigation of the side effects of the selective sodium-calcium exchanger blocker KB-R7943 as an anti-pain drug in rats with streptozotocin-induced type 1 diabetes mellitus. A distribution study of KB-R7943 showed the penetration of KB-R7943 through the blood-brain barrier and its deposition in tissue samples of brain and heart sections. Using ECG analysis, it was shown that KB-R7943 had no negative effect on the cardiovascular system of control and DM1 rats. In the open-field test, the behavior (motor activity and signs of anxiety) of the rats did not change after KB-R7943 administration. An analysis was made of the level of expression of the gene for the voltage-gated sodium channel Nav1.7 (SCN9A), the Î±2Î´-1 subunit of voltage-gated T-type calcium channels (CACNA2D1), Bax and Bcl-2 involved in the pathogenesis of diabetic neuropathy, in the tissues of the hippocampus and hypothalamus.