cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Beidseitige Stimmlippenaugmentation zwecks Stimmverbesserung bei Presbyphonie bei einem 75 Jahre alten Patienten
Creators: name: Hansen, Kevin
name: Kroll, Tobias
name: Lang-Roth, Ruth
name: Klußmann, Jens Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Wir präsentieren den Fall eines 75-jährigen Patienten, welcher sich mit seit drei Jahren progredienter Dypshonie in unserer Poliklinik vorstellte. Eine logopädische Therapie hatte zu keiner Besserung der Stimmqualität geführt. In der stroboskopischen Untersuchung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme
Creators: name: Lewis, Steven M.
name: Harrison, Joseph S.
name: Kuhlman, Brian
name: Kleiger, Gary
name: Hill, Spencer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Lysine selectivity is of critical importance during polyubiquitin chain formation because the identity of the lysine controls the biological outcome. Ubiquitins are covalently linked in polyubiquitin chains through one of seven lysine residues on its surface and the C terminus of adjacent protomers. Lys 48-linked polyubiquitin chains signal for protein degradation; however, the structural basis for Lys 48 selectivity remains largely unknown. The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2. The validity of this interaction was confirmed through biochemical experiments. Since structural examples involving Arg 54 in protein-ubiquitin complexes are exceedingly rare, these results provide additional insight into how ubiquitin-protein complexes can be stabilized. We discuss how these findings relate to how other ubiquitin-conjugating enzymes direct the lysine specificity of polyubiquitin chains.
SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival
Creators: name: Macion, Jennifer
name: Maxfield, Kimberly E.
name: Vankayalapati, Hariprasad
name: Whitehurst, Angelique W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with multiple, distinct molecular subtypes that exhibit unique transcriptional programs and clinical progression trajectories. Despite knowledge of the molecular heterogeneity of the disease, most patients are limited to generic, indiscriminate treatment options: cytotoxic chemotherapy, surgery, and radiation. To identify new intervention targets in TNBC, we used large-scale, loss-of-function screening to identify molecular vulnerabilities among different oncogenomic backgrounds. This strategy returned salt inducible kinase 2 (SIK2) as essential for TNBC survival. Genetic or pharmacological inhibition of SIK2 leads to increased autophagic flux in both normal-immortalized and tumor-derived cell lines. However, this activity causes cell death selectively in breast cancer cells and is biased toward the claudin-low subtype. Depletion of ATG5, which is essential for autophagic vesicle formation, rescued the loss of viability following SIK2 inhibition. Importantly, we find that SIK2 is essential for TNBC tumor growth in vivo . Taken together, these findings indicate that claudin-low tumor cells rely on SIK2 to restrain maladaptive autophagic activation. Inhibition of SIK2 therefore presents itself as an intervention opportunity to reactivate this tumor suppressor mechanism.
เครื่องมือการพัฒนาองค์การในยุคเศรษฐกิจดิจิทัลสำหรับการเป็นองค์การที่มีขีดสมรรถนะสูง
Creators: name: คมกริช นันทะโรจพงศ์
Publisher: name: คณะบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร มหาวิทยาลัยนเรศวร
Year: 2560
Subjects: เครื่องมือการพัฒนาองค์การ
ยุคเศรษฐกิจดิจิทัล
องค์การที่มีขีดสมรรถนะสูง
Organization Development Intervention
Digital Economy
High Performance Organization

description: วารสารบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร, 12, 2, 23-34
L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration
Creators: name: Qiu, Zilong
name: Xiong, Yue
name: Wu, Xiaohui
name: Jiang, Bowen
name: Yang, Pengyuan
name: Ye, Dan
name: Gao, Jun
name: Ji, Minbiao
name: He, Ruoyu
name: Yi, Wei
name: Ma, Shenghong
name: Liu, Peng
name: Sun, Renqiang
name: Guan, Kun-Liang
name: Deng, Wanglong
name: Cui, Jing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: l-2-Hydroxyglutarate aciduria (L-2-HGA) is an autosomal recessive neurometabolic disorder caused by a mutation in the l-2-hydroxyglutarate dehydrogenase (L2HGDH) gene. In this study, we generated L2hgdh knockout (KO) mice and observed a robust increase of l-2-hydroxyglutarate (L-2-HG) levels in multiple tissues. The highest levels of L-2-HG were observed in the brain and testis, with a corresponding increase in histone methylation in these tissues. L2hgdh KO mice exhibit white matter abnormalities, extensive gliosis, microglia-mediated neuroinflammation, and an expansion of oligodendrocyte progenitor cells (OPCs). Moreover, L2hgdh deficiency leads to impaired adult hippocampal neurogenesis and late-onset neurodegeneration in mouse brains. Our data provide in vivo evidence that L2hgdh mutation leads to L-2-HG accumulation, leukoencephalopathy, and neurodegeneration in mice, thereby offering new insights into the pathophysiology of L-2-HGA in humans.
การดำเนินธุรกิจของผู้ประกอบการขนาดเล็กที่ใช้อินเทอร์เน็ตภาคะวันออกเฉียงเหนือ
Creators: name: สุรศักดิ์ วงษ์อินทร์จันทร์
Publisher: name: คณะบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร มหาวิทยาลัยนเรศวร
Year: 2560
Subjects: การใช้อินเทอร์เน็ต
บรอดแบนด์อินเทอร์เน็ต
สมรรถนะการแข่งขัน
ผู้ประกอบการขนาดเล็ก
ภาคตะวันออกเฉียงเหนือ
The use of Internet
Broadband Internet
Competitive Performance
Small Firms
Northeastern Thailand

description: วารสารบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร, 12, 2, 66-78
การพัฒนาระบบสารสนเทศเพื่อชุมชนในการบริหารจัดการพลังงานไฟฟ้าจากพลังงานน้ำ: กรณีศึกษาดอยปู่หมื่น
Creators: name: รัฐนันท์ พงศ์วิริทธิ์ธร
Publisher: name: คณะบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร มหาวิทยาลัยนเรศวร
Year: 2560
Subjects: การพัฒนาระบบสารสนเทศ
ชุมชน
บริหารจัดการ
ไฟฟ้าพลังงานน้ำ
Information System Development
Community
Management
Hydroelectric Energy

description: วารสารบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร, 12, 2, 79-92
Towards an Axiomatic Approach to Hierarchical Clustering of Measures
Creators: name: Thomann, Philipp
name: Steinwart, Ingo
name: Schmid, Nico
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Statistics Theory (math.ST)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: Primary 62H30, Secondary 91C20, 62G07

description: We propose some axioms for hierarchical clustering of probability measures and investigate their ramifications. The basic idea is to let the user stipulate the clusters for some elementary measures. This is done without the need of any notion of metric, similarity or dissimilarity. Our main results then show that for each suitable choice of user-defined clustering on elementary measures we obtain a unique notion of clustering on a large set of distributions satisfying a set of additivity and continuity axioms. We illustrate the developed theory by numerous examples including some with and some without a density.
การสื่อสารความเป็นตราสินค้าระดับโลกของตราสินค้าระดับโลกและตราสินค้าท้องถิ่นในประเทศไทย
Creators: name: เสาวภา พิณเขียว
Publisher: name: คณะบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร มหาวิทยาลัยนเรศวร
Year: 2560
Subjects: การสื่อสารตราสินค้าระดับโลก
การรับรู้ความเป็นตราสินค้าระดับโลก
การรับรู้คุณภาพตราสินค้า
ความตั้งใจซื้อของผู้บริโภค
Global Brand Communication
Brand Globalness
Perceived Brand Globalness
Perceived Brand Quality

description: วารสารบริหารธุรกิจ เศรษฐศาสตร์และการสื่อสาร, 12, 2, 93-109
p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex
Creators: name: Chen, Heping
name: Wu, Tongde
name: Tao, Shasha
name: Liu, Pengfei
name: Tillotson, Joseph
name: Luo, Gang
name: Chapman, Eli
name: Zhang, Donna D.
name: de la Vega, Montserrat Rojo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Activation of the stress-responsive transcription factor NRF2 is the major line of defense to combat oxidative or electrophilic insults. Under basal conditions, NRF2 is continuously ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for degradation (the canonical mechanism). However, the path from the CUL3 complex to ultimate proteasomal degradation was previously unknown. p97 is a ubiquitin-targeted ATP-dependent segregase that extracts ubiquitylated client proteins from membranes, protein complexes, or chromatin and has an essential role in autophagy and the ubiquitin proteasome system (UPS). In this study, we show that p97 negatively regulates NRF2 through the canonical pathway by extracting ubiquitylated NRF2 from the KEAP1-CUL3 E3 complex, with the aid of the heterodimeric cofactor UFD1/NPL4 and the UBA-UBX-containing protein UBXN7, for efficient proteasomal degradation. Given the role of NRF2 in chemoresistance and the surging interest in p97 inhibitors to treat cancers, our results indicate that dual p97/NRF2 inhibitors may offer a more potent and long-term avenue of p97-targeted treatment.
An extreme [OIII] emitter at $z=3.2$: a low metallicity Lyman continuum source
Creators: name: de Barros, S.
name: Vanzella, E.
name: Amorín, R.
name: Castellano, M.
name: Siana, B.
name: Grazian, A.
name: Suh, H.
name: Balestra, I.
name: Vignali, C.
name: Verhamme, A.
name: Zamorani, G.
name: Mignoli, M.
name: Hasinger, G.
name: Comastri, A.
name: Pentericci, L.
name: Pérez-Montero, E.
name: Fontana, A.
name: Giavalisco, M.
name: Gilli, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: [Abridged] We investigate the physical properties of a Lyman continuum emitter candidate at $z=3.212$ with photometric coverage from $U$ to MIPS 24$μ$m band and VIMOS/VLT and MOSFIRE/Keck spectroscopy. Investigation of the UV spectrum confirms a direct spectroscopic detection of the Lyman continuum emission with $S/N>5$. Non-zero Ly$α$ flux at the systemic redshift and high Lyman-$α$ escape fraction suggest a low HI column density. The weak C and Si low-ionization absorption lines are also consistent with a low covering fraction along the line of sight. The [OIII]$λ\lambda4959,5007+\mathrm{H}β$ equivalent width is one of the largest reported for a galaxy at $z>3$ ($\mathrm{EW}([\mathrm{OIII}]λ\lambda4959,5007+\mathrm{H}β) \simeq 1600Å$, rest-frame) and the NIR spectrum shows that this is mainly due to an extremely strong [OIII] emission. The large observed [OIII]/[OII] ratio ($>10$) and high ionization parameter are consistent with prediction from photoionization models in case of a density-bounded nebula scenario. Furthermore, the $\mathrm{EW}([\mathrm{OIII}]λ\lambda4959,5007+\mathrm{H}β)$ is comparable to recent measurements reported at $z\sim7-9$, in the reionization epoch. We also investigate the possibility of an AGN contribution to explain the ionizing emission but most of the AGN identification diagnostics suggest that stellar emission dominates instead. This source is currently the first high-$z$ example of a Lyman continuum emitter exhibiting indirect and direct evidences of a Lyman continuum leakage and having physical properties consistent with theoretical expectation from Lyman continuum emission from a density-bounded nebula.
description: 14 pages, 11 figures, accepted for publication in A&A. Minor modifications, Figure 2 updated, Figure 9 added
Studie užití výzkumných dat v rámci vybraných vědních oborů
Creators: name: Hanzlíková, Dagmar
name: Janíček, Milan
Publisher: name: Zenodo
Year: 2022
Subjects: research data management
RDM
open science

description: Tato studie vznikla jako klíčový výstup v rámci projektu OP VVV Rozvoj kapacit pro výzkum a vývoj UK II, reg. č.: CZ.02.2.69/0.0/0.0/18_054/0015222. Cílem studie je analyzovat situaci v oblasti správy výzkumných dat na Univerzitě Karlově a porovnat ji se současnými trendy – především v oblastech správy dat a jejího plánování, vytváření výzkumných dat v souladu s principy FAIR s následnou možností sdílení. Tento dokument má tři základní části: Obecný popis principů správy vědeckých dat směřujících k vytváření dat splňujících principy FAIR Analýza současného stavu na Univerzitě Karlově Situace na vybraných zahraničních univerzitách V závěru shrnuje aktuální situaci a identifikujeme oblasti, kde vidíme příležitost ke zlepšení a dalšímu rozvoji.
Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis
Creators: name: Leung, Janet Y.
name: Kim, William Y.
name: Wobker, Sara E.
name: Wilson, Harper L.
name: Lee, Hyo Jin
name: Voltzke, Kristin J.
name: Williams, Lindsay A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Tubulointerstitial fibrosis (TIF) is recognized as a final phenotypic manifestation in the transition from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Here we show that conditional inactivation of Sav1 in the mouse renal epithelium resulted in upregulated expression of profibrotic genes and TIF. Loss of Sav1 induced Stat3 activation and a senescence-associated secretory phenotype (SASP) that coincided with the development of tubulointerstitial fibrosis. Treatment of mice with the YAP inhibitor verteporfin (VP) inhibited activation of genes associated with senescence, SASPs, and activation of Stat3 as well as impeded the development of fibrosis. Collectively, our studies offer novel insights into molecular events that are linked to fibrosis development from Sav1 loss and implicate VP as a potential pharmacological inhibitor to treat patients at risk for developing CKD and TIF.
Theory of Quantum Imaging with Undetected Photons
Creators: name: Lahiri, Mayukh
name: Lapkiewicz, Radek
name: Lemos, Gabriela Barreto
name: Zeilinger, Anton
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A novel quantum imaging technique has recently been demonstrated in an experiment, where the photon used for illuminating an object is not detected; the image is obtained by interfering two beams, none of which ever interacts with the object. Here we present a detailed theoretical analysis of the experiment. We show that the object information is present only in the interference term and not in the individual intensities of the interfering beams. We also theoretically establish that the magnification of the imaging system depends on two wavelengths: the average wavelength of the photon that illuminates the object and the average wavelength of the photon that is detected. Our analysis affirms that the imaging process is based on the principle that quantum interference occurs when interferometric path information is unavailable.
description: 8 pages
تعیین شاخص های تعیین کننده منابع ملموس و ناملموس و تاثیر آنها بر عملکرد صادراتی
Creators: name: Salehi, Nader
name: Salimi, Maryam
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 350605
subject: Marketing management (incl. strategy and customer relations)
classificationCode: 350604
subject: Marketing communications
classificationCode: 350699
subject: Marketing not elsewhere classified

description: یکی از دلایل عمده کاهش صادرات فرش ایران کاهش تقاضای جهانی برای آن بوده است. از سوی دیگر در یکی دو دهه اخیر رقبایی جدی برای ایران مانند چین، هند، پاکستان، نپال و ترکیه به وجود آمدهاند که این صنعت را با چالش جدی مواجه ساختهاند. عوامل زیر بنایی که کشورها و شرکتها را به تجارت بینالمللی تشویق می کند پیچیده و بسیارند. براساس مطالعات صورت گرفته در می یابیم که منابع ناملموس) حقوق مالکیت، دارایی مدیریتی، دارایی ارتباطی ( نقش مهمی در عملکرد صادرات دارند. همچنین منابع ملموس) منابع انسانی و قابلیت تولید (و اهمیت آنها در مطالعات پیشین مورد توجه قرار گرفته است. هدف این تحقیق عبارتست از بهبود عملکرد صادراتی شرکتهای صادر کننده و همچنین تاثیر منابع ملموس و ناملموس بر عملکرد صادراتی شرکتهای صادر کننده فرش و مقایسه نحوه میزان اهمیت و تاثیر این منابع می باشد. شاخص های تعیین کننده مولفه های منابع ملموس و ناملموس بر عملکرد صادراتی به منظور جمع آوری داده ها و اطلاعات آورده شده است. همچنین تعاریف مفهومی و عملیاتی متغیرهای تحقیق در بخش پیشینه تحقیق آورده شده است.
VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1
Creators: name: Kernan, Jennifer L.
name: Choudhury, Rajarshi
name: Wang, Xianxi
name: Bird, Kelly
name: Mills, Christine A.
name: Zhou, Chunxiao
name: Bae-Jump, Victoria
name: Bowers, Albert
name: Emanuele, Michael J.
name: Arceci, Anthony
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The oncogenic transcription factor FoxM1 plays a vital role in cell cycle progression, is activated in numerous human malignancies, and is linked to chromosome instability. We characterize here a cullin 4-based E3 ubiquitin ligase and its substrate receptor, VprBP/DCAF1 (CRL4VprBP), which we show regulate FoxM1 ubiquitylation and degradation. Paradoxically, we also found that the substrate receptor VprBP is a potent FoxM1 activator. VprBP depletion reduces expression of FoxM1 target genes and impairs mitotic entry, whereas ectopic VprBP expression strongly activates a FoxM1 transcriptional reporter. VprBP binding to CRL4 is reduced during mitosis, and our data suggest that VprBP activation of FoxM1 is ligase independent. This implies a nonproteolytic activation mechanism that is reminiscent of, yet distinct from, the ubiquitin-dependent transactivation of the oncoprotein Myc by other E3s. Significantly, VprBP protein levels were upregulated in high-grade serous ovarian patient tumors, where the FoxM1 signature is amplified. These data suggest that FoxM1 abundance and activity are controlled by VprBP and highlight the functional repurposing of E3 ligase substrate receptors independent of the ubiquitin system.
title: Μοντελοποίηση του κύκλου ζωής προϊόντων με βάση την πολυκριτήρια ανάλυση

Creators: name: Ζαφειριδου Μαρινα
Publisher: name: Technical University of Crete
Year: 2023

description: Η μελέτη της πορείας ενός προϊόντος σε όλη τη διάρκεια ζωής του, των παραγόντων
που την επηρεάζουν και η επιλογή των παρεμβάσεων που πρέπει να γίνουν σε κάθε
φάση του, αποτελούν ένα από τα σημαντικότερα προβλήματα στο χώρο του
μάρκετινγκ. Η ανάπτυξη μεθοδολογιών βασισμένων στην πολυκριτήρια ανάλυση
της συμπεριφοράς των καταναλωτών καθώς και του κατάλληλου λογισμικού για την
παρακολούθηση μιας συγκεκριμένης ‘αγοράς’, θα ενίσχυαν τη λήψη στρατηγικών
αποφάσεων μάρκετινγκ.
Στόχος της διπλωματικής εργασίας είναι, η παρακολούθηση της αγοραστικής
συμπεριφοράς και των παραμέτρων που την επηρεάζουν σε διαφορετικές χρονικές
στιγμές του κύκλου ζωής προϊόντων. Συγκεκριμένα, θα βασίζεται στην ανάλυση
συμπεριφοράς των καταναλωτών μέσω πολυκριτήριων μεθοδολογιών και την
δημιουργία κατάλληλων τμημάτων της αγοράς. Τα διάφορα χαρακτηριστικά του
υπό μελέτη προϊόντος, θα μελετώνται σε σχέση με των αντίστοιχων ανταγωνιστικών
προϊόντων, σε διάφορες χρονικές στιγμές του κύκλου ζωής του.
Με βάση αυτά, θα μοντελοποιηθεί ο μηχανισμός εξέλιξης του κύκλου ζωής
προϊόντων με βάση την πολυκριτήρια ανάλυση συμπεριφοράς καταναλωτών έτσι
ώστε να είναι δυνατή η εφαρμογή διαφόρων σεναρίων ανάπτυξης νέων
προϊόντων/υπηρεσιών και η λήψη των σχετικών αποφάσεων.
From $r$-Spin Intersection Numbers to Hodge Integrals
Creators: name: Ding, Xiang-Mao
name: Li, Yuping
name: Meng, Lingxian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Algebraic Geometry (math.AG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Generalized Kontsevich Matrix Model (GKMM) with a certain given potential is the partition function of $r$-spin intersection numbers. We represent this GKMM in terms of fermions and expand it in terms of the Schur polynomials by boson-fermion correspondence, and link it with a Hurwitz partition function and a Hodge partition by operators in a $\widehat{GL}(\infty)$ group. Then, from a $W_{1+\infty}$ constraint of the partition function of $r$-spin intersection numbers, we get a $W_{1+\infty}$ constraint for the Hodge partition function. The $W_{1+\infty}$ constraint completely determines the Schur polynomials expansion of the Hodge partition function.
description: 51 pages, 1 figure
Receptor antagonism/agonism can be uncoupled from pharmacoperone activity
Creators: name: Bannister, Thomas D.
name: Smith, Emery
name: Spicer, Timothy P.
name: Janovick, Jo Ann
name: Kenakin, Terry
name: Conn, P. Michael
name: Scampavia, Louis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Pharmacoperones rescue misrouted mutants of the vasopressin receptor type 2 (V2R) and enable them to traffic to the correct biological locus where they function. Previously, a library of nearly 645,000 structures was interrogated with a high throughput screen; pharmacoperones were identified for V2R mutants with a view toward correcting the underlying mutational defects in nephrogenic diabetes insipidus. In the present study, an orthologous assay was used to evaluate hits from the earlier study. We found no consistent relation between antagonism or agonism and pharmacoperone activity. Active pharmacoperones were identified which had minimal antagonistic activity. This increases the therapeutic reach of these drugs, since virtually all pharmacoperone drugs reported to date were selected from peptidomimetic antagonists. Such mixed-activity drugs have a complex pharmacology limiting their therapeutic utility and requiring their removal prior to stimulation of the receptor with agonist.
RAVE as a Gaia precursor: what to expect from the Gaia RVS?
Creators: name: Steinmetz, Matthias
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Radial Velocity Experiment (RAVE) is a large wide-field spectroscopic stellar survey of the Milky Way. Over the period 2003-2013, 574,630 spectra for 483,330 stars have been amassed at a resolution of R=7500 in the Ca-triplet region of 8410-8795Å. Wavelength coverage and resolution are thus comparable to that anticipated from the Gaia RVS. Derived data products of RAVE include radial velocities, stellar parameters, chemicals abundances for Mg, Al, Si, Ca, Ti, Fe, and Ni, and absorption measures based on the diffuse interstellar bands (DIB) at 8620Å. Since more than 290000 RAVE targets are drawn from the Tycho-2 catalogue, RAVE will be an interesting prototype for the anticipated full Gaia data releases, in particular when combined with the early Gaia data releases, which contain astrometry but not yet stellar parameters and abundances.
description: 7 pages, 3 color figures. Invited contribution to the GREAT-ITN conference "The Milky Way Unravelled by Gaia: GREAT Science from the Gaia Data Releases", 1-5 December 2014, University of Barcelona, Spain, EAS Publications Series, eds Nicholas Walton, Francesca Figueras, and Caroline Soubiran
Noise in pulsar timing arrays
Creators: name: Wang, Yan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: To successfully detect gravitational waves with pulsar timing arrays, we need to have a comprehensive understanding of the physical origins and statistical characteristics of the noise in pulse arrival times and identify mitigation methods to reduce the noise. In this paper we will review radiometer noise, phase jitter noise and timing noise in the noise budget of pulsar timing and show various efforts used to reduce them. We will briefly discuss the results of an overall assessment of the components and physical causes of the timing residuals for millisecond pulsars in the North American Nanohertz Observatory for Gravitational Waves (NANOGrav).
description: 8 pages, to be published in the proceeding of the 10th LISA Symposium
Cross-Layer Design of Wireless Multihop Networks over Stochastic Channels with Time-Varying Statistics
Creators: name: Stai, Eleni
name: Loulakis, Michail
name: Papavassiliou, Symeon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Systems and Control (eess.SY)
subject: Probability (math.PR)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics
subject: 93E20

description: Network Utility Maximization (NUM) is often applied for the cross-layer design of wireless networks considering known wireless channels. However, realistic wireless channel capacities are stochastic bearing time-varying statistics, necessitating the redesign and solution of NUM problems to capture such effects. Based on NUM theory we develop a framework for scheduling, routing, congestion and power control in wireless multihop networks that considers stochastic Long or Short Term Fading wireless channels. Specifically, the wireless channel is modeled via stochastic differential equations alleviating several assumptions that exist in state-of-the-art channel modeling within the NUM framework such as the finite number of states or the stationarity. Our consideration of wireless channel modeling leads to a NUM problem formulation that accommodates non-convex and time-varying utilities. We consider both cases of non orthogonal and orthogonal access of users to the medium. In the first case, scheduling is performed via power control, while the latter separates scheduling and power control and the role of power control is to further increase users' optimal utility by exploiting random reductions of the stochastic channel power loss while also considering energy efficiency. Finally, numerical results evaluate the performance and operation of the proposed approach and study the impact of several involved parameters on convergence.
SU(5) orbifold GUT in noncommutative geometry
Creators: name: Yang, Masaki J. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper, we appliy the orbifold GUT mechanism to the SU(5) model in noncommutative geometry, including the fermonic sector. Imposing proper parity assignments for "constituent fields" of bosons and fermions, the couplings between fermions and the heavy bosons $X_μ, Y_μ$, and $ H^{c}$ are prohibited by the parity symmetry. As a result, the derived fermionic Lagrangian is just that of the standard model, and proton decay is forbidden at tree level. If quantum fluctuation respects the parity symmetry, the process will be naturally suppressed or even forbidden completely.
description: 13 pages, the final version to appear in Progress of Theoretical and Experimental Physics (PTEP)
Androgen receptor regulation by histone methyltransferase Suppressor of variegation 3-9 homolog 2 and Melanoma antigen-A11
Creators: name: Parris, Amanda B.
name: Minges, John T.
name: Wilson, Elizabeth M.
name: Askew, Emily B.
name: Bai, Suxia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Androgen receptor (AR) transcriptional activity depends on interactions between the AR NH2-terminal region and transcriptional coregulators. A yeast two-hybrid screen of a human testis library using predicted α-helical NH2-terminal fragment AR-(370–420) as bait identified suppressor of variegation 3–9 homolog 2 (SUV39H2) histone methyltransferase as an AR interacting protein. SUV39H2 interaction with AR and the AR coregulator, melanoma antigen-A11 (MAGE-A11), was verified in two-hybrid, in vitro glutathione S-transferase affinity matrix and coimmunoprecipitation assays. Fluorescent immunocytochemistry colocalized SUV39H2 and AR in the cytoplasm without androgen, in the nucleus with androgen, and with MAGE-A11 in the nucleus independent of androgen. Chromatin immunoprecipitation using antibodies raised against SUV39H2 demonstrated androgen-dependent recruitment of AR and SUV39H2 to the androgen-responsive upstream enhancer of the prostate-specific antigen gene. SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity. SUV39H2 histone methyltransferase is an AR coactivator that increases androgen-dependent transcriptional activity through interactions with AR and MAGE-A11.
Effective distributions of quasi-particles for thermal photons
Creators: name: Monnai, Akihiko
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: It has been found in recent heavy-ion experiments that the second and the third flow harmonics of direct photons are larger than most theoretical predictions. In this study, I construct effective parton phase-space distributions with in-medium interaction using quasi-particle models so that they are consistent with a lattice QCD equation of state. Then I investigate their effects on thermal photons using a hydrodynamic model. Numerical results indicate that elliptic flow and transverse momentum spectra are modified by the corrections to Fermi-Dirac and Bose-Einstein distributions.
description: 6 pages, 5 figures
Integration of derivations for Lie $2$-algebras
Creators: name: Lang, Honglei
name: Liu, Zhangju
name: Sheng, Yunhe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper, for a Lie 2-algebra $\g$, we construct the automorphism 2-group $\Aut(\g)$, which turns out to be an integration of the derivation Lie 2-algebra $\Der(\g)$.
description: to appear in Transformation Groups
Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2)
Creators: name: MacGibbon, Kimber W.
name: Martin, Nicholas G.
name: Medland, Sarah E.
name: Mullin, Patrick M.
name: Colodro-Conde, Lucía
name: Magnus, Per
name: Pajukanta, Päivi
name: Reddy, M.V. Prasad Linga
name: Sinsheimer, Janet S.
name: Myhre, Ronny
name: Wright, Margaret J.
name: Fejzo, Marlena Schoenberg
name: Engel, Stephanie M.
name: Nyholt, Dale R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Hyperemesis Gravidarum (HG), severe nausea/vomiting in pregnancy (NVP), can cause poor maternal/fetal outcomes. Genetic predisposition suggests the genetic component is essential in discovering an etiology. We performed whole-exome sequencing of 5 families followed by analysis of variants in 584 cases/431 controls. Variants in RYR2 segregated with disease in 2 families. The novel variant L3277R was not found in any case/control. The rare variant, G1886S was more common in cases (p = 0.046) and extreme cases (p = 0.023). Replication of G1886S using Norwegian/Australian data was supportive. Common variants rs790899 and rs1891246 were significantly associated with HG and weight loss. Copy-number analysis revealed a deletion in a patient. RYR2 encodes an intracellular calcium release channel involved in vomiting, cyclic-vomiting syndrome, and is a thyroid hormone target gene. Additionally, RYR2 is a downstream drug target of Inderal, used to treat HG and CVS. Thus, herein we provide genetic evidence for a pathway and therapy for HG.
title: Lymphoepitheliales Karzinom an der Oberlippe – ein Fallbericht
Creators: name: Breitrück, Nils Yannick
name: Kraft, Stefan
name: Diaz, Carlos
name: Klussmann, Jens Peter
name: Kroll, Tobias
name: Schwarz, David
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Lymphoepitheliale Karzinome (LEC) im Kopf-/Halsbereich werden pathologisch als undifferenziert und nicht-verhornend klassifiziert und sind häufig im Nasopharynx und den Speicheldrüsen lokalisiert. In diesem Fallbericht wird das Management eines LECs an der Haut der Oberlippe[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
MAST: a hybrid Multi-Agent Spatio-Temporal model of tumor microenvironment informed using a data-driven approach
Creators: name: Cesaro, Giulia
name: Milia, Mikele
name: Baruzzo, Giacomo
name: Finco, Giovanni
name: Morandini, Francesco
name: Lazzarini, Alessio
name: Alotto, Piergiorgio
name: da Cunha Carvalho de Miranda, Noel Filipe
name: Trajanoski, Zlatko
name: Finotello, Francesca
name: Di Camillo, Barbara
Publisher: name: Zenodo
Year: 2022
Subjects: bioinformatics
TME
agent-based model
tumor microenvironment
data-driven
simulator
spatio-temporal dynamics of cancer development
bulk RNA-seq
single cell RNA-seq

description: This page contains the software and test data used in MAST: a hybrid Multi-Agent Spatio-Temporal model of tumor microenvironment informed using a data-driven approach. Software Folder Software contains the source code of MAST (file mast.zip). MAST is a software written in Python, freely available at https://gitlab.com/sysbiobig/mast. Data Folder Data contains the file data.zip within which are provided: all system configuration (.dat) files all generated tabular outputs (.csv) files the setup (.sim) file, which is mandatory to perform simulations a README.md file Tabular output files are divided into three main folders, namely manuscript_configuration, parameter_effects and source_effects. Specifically: - manuscript_configuration: contains for each CMS (e.g., CMS1, CMS2, CMS3 and CMS4) the configuration (.dat) and the tabular output (.csv) files generated by MAST used as main results in the manuscript - parameter_effects: contains for each parameter variation within each CMS the configuration (.dat) and the tabular output (.csv) files generated by MAST - source_effects: contains for each CMS the configuration (.dat) and tabular output (.csv) files generated by MAST based on the available source, respectively bulk RNA-seq or scRNA-seq data. The bulk gene expression data were retrieved from The Cancer Genome Atlas (TCGA) program, following the same procedure used by Santana et al. to obtain transcripts of million (Lapuente-Santana et al., 2021). The single-cell expression data were retrieved from a publicly available scRNA-seq dataset of human colorectal cancer from the Samsung Medical Center (SMC) (Lee et al., 2020). The pre-processed gene expression matrix and relative metadata were retrieved by GEO (GSE132465). Further details on folder structures and files usage are provided within the aforementioned README.md file. Additional references: Lapuente-Santana,Ó. et al. (2021) Interpretable systems biomarkers predict response to immune-checkpoint inhibitors. Patterns, 2, 100293. Lee,H.O. et al. (2020) Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat Genet, 52, 594–603.
title: Lebensqualität und Gerätezufriedenheit nach Implantation des Knochenleitungs-implantates – BONEBRIDGE®
Creators: name: Sosnik, Christina
name: Neumann, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Hörverlust ist ein häufiges Problem. Ursachen für eine Schallleitungs- oder eine kombinierte Schwerhörigkeit sind divers und können Lärm, chronische Infektionen oder angeborene Fehlbildungen sein. Eine Alternative zur Hörgeräteversorgung bei Menschen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Uffizi TikTok Analytics - Grafico radar eta^2
Creators: name: Falorni, Elisabetta
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 470101
subject: Communication studies

description: Grafico rappresentante le percentuali di eta quadro ottenute tramite un'analisi quantitativa di un campione di video pubblicati sull'account TikTok istituzionale delle Gallerie degli Uffizi. Tale grafico mostra quanto determinate categorie contenutistiche impattano su determinato metriche considerate nell'ambito dell'analisi.
title: Über die Entwicklung der Operationsmethoden zur Rekonstruktion des Nasenseptums und von Nasenseptumdefekten
Creators: name: Stange, Thoralf
name: Pirsig, Wolfgang
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die unübersehbare Vielzahl von verschiedenen Operationsmethoden zur Rekonstruktion des Nasenseptums war der Anlass, die historische und aktuelle Literatur zu dieser Thematik aufzuarbeiten. Zunächst werden die unterschiedlichen Rekonstruktionsmethoden dargestellt und dann der allmähliche[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Effective topological complexity of spaces with symmetries
Creators: name: Błaszczyk, Zbigniew
name: Kaluba, Marek
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55M30, 68T40

description: We introduce a version of Farber's topological complexity suitable for investigating mechanical systems whose configuration spaces exhibit symmetries. Our invariant has vastly different properties to the previous approaches of Colman-Grant, Dranishnikov and Lubawski-Marzantowicz. In particular, it is bounded from above by Farber's topological complexity.
description: New title; a short section with open problems included at the end of the paper. Numerous minor improvements throughout the text. Final version, to appear in Publ. Mat. 19 pages, 2 figures
Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation
Creators: name: Grossman, Gail
name: Chen, Xiaoyu
name: Minges, John T.
name: Geng, Jiang
name: Wilson, Elizabeth M.
name: Su, Shifeng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Melanoma antigen-A11 (MAGE-A11) is a proto-oncogene involved in androgen receptor signaling and androgen-dependent cell growth. In this report we provide evidence that MAGE-A11 interacts with Skp2 (S phase kinase-associated protein), the substrate recognition protein of the Skp1-Cullin1-F-box E3 ubiquitin ligase, and with Skp2 binding protein, cyclin A. A similar cyclin A binding motif in MAGE-A11 and Skp2 was consistent with a competitive relationship between MAGE-A11 and Skp2 in binding cyclin A. Skp2 inhibited MAGE-A11 interaction with cyclin A. Differential effects of MAGE-A11 on Skp2-mediated protein degradation were also revealed. MAGE-A11 increased Skp2-mediated degradation of cyclin A and retinoblastoma-related protein p130. In contrast, MAGE-A11 decreased Skp2-mediated degradation of E2F1 and Skp2 self-ubiquitination. Stabilization of E2F1 by MAGE-A11 was associated with sequestration and inactivation of Skp2 through the formation of an E2F1-MAGE-A11-Skp2 complex. We conclude that direct interactions of MAGE-A11 with Skp2 and cyclin A regulate the substrate-specificity of Skp2-mediated protein degradation.
Metastable Phase Formation, Microstructure, and Dielectric Properties in Plasma-Sprayed Alumina Ceramic Coatings
Creators: name: Junge, Paul
name: Greinacher, Moritz
name: Kober, Delf
name: Stargardt, Patrick
name: Rupprecht, Christian
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 660 Chemische Verfahrenstechnik
subject: alumina
subject: phase formation
subject: plasma spray
subject: dielectric properties
subject: spray distance
subject: coatings
subject: microstructure

description: The need for new solutions for electrical insulation is growing due to the increased electrification in numerous industrial sectors, opening the door for innovation. Plasma spraying is a fast and efficient way to deposit various ceramics as electrical insulators, which are used in conditions where polymers are not suitable. Alumina (Al2O3) is among the most employed ceramics in the coating industry since it exhibits good dielectric properties, high hardness, and high melting point, while still being cost-effective. Various parameters (e.g., feedstock type, spray distance, plasma power) significantly influence the resulting coating in terms of microstructure, porosity, and metastable phase formation. Consequently, these parameters need to be investigated to estimate the impact on the dielectric properties of plasma-sprayed alumina coatings. In this work, alumina coatings with different spray distances have been prepared via atmospheric plasma spray (APS) on copper substrates. The microstructure, porosity, and corresponding phase formation have been analyzed with optical microscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). Moreover, we present an in-depth analysis of the fundamental dielectric properties e.g., direct current (DC) resistance, breakdown strength, dielectric loss tangent, and permittivity. Our results show that decreasing spray distance reduces the resistivity from 6.31 × 109 Ωm (130 mm) to 6.33 × 108 Ωm (70 mm), while at the same time enhances the formation of the metastable δ-Al2O3 phase. Furthermore, space charge polarization is determined as the main polarization mechanism at low frequencies.
title: Fallbericht über einen Apoplex als Erstmanifestation einer Hereditären hämorrhagischen Teleangiektasie (HHT)
Creators: name: Dingemann, Julia
name: Thangavelu, Kruthika
name: Bosch, Jan
name: Kaster, Friederike
name: Lang, Stephan
name: Dröge, Freya
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Hereditäre hämorrhagische Teleangiektasie (HHT) ist eine systemische autosomal dominant vererbbare Erkrankung. Die Diagnose wird entweder klinisch anhand der Curaçao-Kriterien oder anhand einer genetischen Untersuchung gestellt. Organmanifestationen betreffen insbesondere[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Passenger Acceptability of Teleoperation in Railways
Creators: name: Cogan, Baris
name: Tandetzki, Julia
name: Milius, Birgit
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 380 Handel, Kommunikation, Verkehr
subject: railways
subject: remote operation
subject: acceptability
subject: conjoint analysis
subject: passengers
subject: teleoperation

description: In this survey-based study, passenger awareness and acceptability of potential teleoperation services in the railway domain were analyzed. The literature on the important factors for the acceptability of automated transport was reviewed. These factors were adapted to teleoperation in the railway domain. An online survey was conducted for obtaining passengers’ views on automated rail transport and the remote control of trains. A choice-based conjoint analysis was conducted to obtain user preferences regarding a potential teleoperation service. Overall, the teleoperation system and its capabilities received positive feedback. While increased resilience and reliability of rail services were identified as potential opportunities for higher acceptance, safety and security concerns of prospective passengers were highlighted as influencing factors.
title: Die Applikation eines Mometason-Stents in der Behandlung von Patienten mit chronischer Sinusitis mit Polyposis
Creators: name: Duong Dinh, Thien An
name: Mici, Elidon
name: Ilgner, Justus
name: Westhofen, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Patienten, welche eine endonasal endoskopische Nasennebenhöhlen-Operation erhalten, leiden postoperative häufig an Komplikationen wie Entzündungen, Schwellung, Narbenbildungen. Nicht selten kommt es ebenfalls zur Rezidivpolyposis mit Notwendigkeit einer Revision. Resorbierbare[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Reversible Ratchet Effects for Vortices in Conformal Pinning Arrays
Creators: name: Reichhardt, C.
name: Ray, D.
name: Reichhardt, C. J. Olson
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A conformal transformation of a uniform triangular pinning array produces a structure called a conformal crystal which preserves the six-fold ordering of the original lattice but contains a gradient in the pinning density. Here we use numerical simulations to show that vortices in type-II superconductors driven with an ac drive over gradient pinning arrays produce the most pronounced ratchet effect over a wide range of parameters for a conformal array, while square gradient or random gradient arrays with equivalent pinning densities give reduced ratchet effects. In the conformal array, the larger spacing of the pinning sites in the direction transverse to the ac drive permits easy funneling of interstitial vortices for one driving direction, producing the enhanced ratchet effect. In the square array, the transverse spacing between pinning sites is uniform, giving no asymmetry in the funneling of the vortices as the driving direction switches, while in the random array, there are numerous easy-flow channels present for either direction of drive. We find multiple ratchet reversals in the conformal arrays as a function of vortex density and ac amplitude, and correlate the features with a reversal in the vortex ordering, which is greater for motion in the ratchet direction. The enhanced conformal pinning ratchet effect can also be realized for colloidal particles moving over a conformal array, indicating the general usefulness of conformal structures for controlling the motion of particles.
description: 10 pages, 14 postscript figures