cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart
Creators: name: Weibin Guo
name: Chaoqun Zhu
name: Zhiyong Yin
name: Qiurong Wang
name: Mingming Sun
name: Huojun Cao
name: Greaser, Marion L.
Publisher: name: Health Research Alliance
Year: 2019
Subjects: subject: 60405 Gene Expression (incl. Microarray and other genome-wide approaches)
subject: FOS: Biological sciences
subject: Cardiology
subject: Cell Biology

description: RNA binding motif 20 (RBM20) regulates pre-mRNA splicing of over thirty genes, among which titin is a major target. With RBM20 expression, titin expresses a larger isoform at fetal stage to a smaller isoform at adult resulting from alternative splicing, while, without RBM20, titin expresses exclusively a larger isoform throughout all ages. In addition to splicing regulation, it is unknown whether RBM20 also regulates gene expression. In this study, we employed Rbm20 knockout rats to investigate gene expression profile using Affymetrix expression array. We compared wild type to Rbm20 knockout at day1, 20 and 49. Bioinformatics analysis showed RBM20 regulates fewer genes expression at younger age and more at older age and commonly expressed genes have the same trends. GSEA indicated up-regulated genes are associated with heart failure. We examined titin binding partners. All titin direct binding partners are up-regulated and their increased expression is associated with dilated cardiomyopathy. Particularly, we found that genes involving calcium handling and muscle contraction are changed by RBM20. Intracellular calcium level measurement with individual cardiomyocytes further confirmed that changes of these proteins impact calcium handling. Selected genes from titin binding partners and calcium handling were validated with QPCR and western blotting. These data demonstrate that RBM20 regulates gene splicing as well as gene expression. Altered gene expression by RBM20 influences protein-protein interaction, calcium releasing and thus muscle contraction. Our results first reported gene expression impacted by RBM20 with heart maturation, and provided new insights into the role of RBM20 in the progression of heart failure.
Additional file 1 of Effects of altitude on thyroid disorders according to Chinese three-rung, ladder-like topography: national cross-sectional study
Creators: name: Gong, Boshen
name: Wang, Youmin
name: Zhang, Jin-an
name: Zhang, Qiao
name: Zhao, Jiajun
name: Li, Jiashu
name: Wang, Xichang
name: Han, Yutong
name: Yu, Ziwei
name: Zhang, Chenyu
name: Peng, Bingcong
name: Xing, Yumin
name: Li, Qiuxian
name: Wang, Ping
name: Li, Yongze
name: Teng, Weiping
name: Shan, Zhongyan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplemental Figure 1. Flowchart depicting survey design. Supplemental Figure 2. Random forest variable importance analysis. Supplemental Figure 3. Shapley Additive Explanations Summary Plot analysis. Supplemental Table 1. Diagnostic Criteria for Thyroid Disorders. Supplemental Table 2. Prevalence of Thyroid Disorders According to the Three-rung Ladder-Like Topography Group.
Climate Coffees presentation: Co-created scenarios as a tool for preparation for uncertain futures
Creators: name: Vilena Valeeva
Publisher: name: Zenodo
Year: 2021

description: A presentation on 17th June 2021 by Vilena Valeeva (Institute of Advanced Sustainability Studies, Potsdam, DE), on "Yamal 2040: Co-created scenarios as a tool for preparation for uncertain futures." Climate Coffees are organised by Blue-Action and the European Climate Research Alliance, and are a series of peer sharing events run by climate scientists to exchange knowledge and discussions.
ICLabel: An automated electroencephalographic independent component classifier, dataset, and website
Creators: name: Pion-Tonachini, Luca
name: Kreutz-Delgado, Ken
name: Makeig, Scott
Publisher: name: arXiv
Year: 2019
Subjects: subject: Signal Processing (eess.SP)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: The electroencephalogram (EEG) provides a non-invasive, minimally restrictive, and relatively low cost measure of mesoscale brain dynamics with high temporal resolution. Although signals recorded in parallel by multiple, near-adjacent EEG scalp electrode channels are highly-correlated and combine signals from many different sources, biological and non-biological, independent component analysis (ICA) has been shown to isolate the various source generator processes underlying those recordings. Independent components (IC) found by ICA decomposition can be manually inspected, selected, and interpreted, but doing so requires both time and practice as ICs have no particular order or intrinsic interpretations and therefore require further study of their properties. Alternatively, sufficiently-accurate automated IC classifiers can be used to classify ICs into broad source categories, speeding the analysis of EEG studies with many subjects and enabling the use of ICA decomposition in near-real-time applications. While many such classifiers have been proposed recently, this work presents the ICLabel project comprised of (1) an IC dataset containing spatiotemporal measures for over 200,000 ICs from more than 6,000 EEG recordings, (2) a website for collecting crowdsourced IC labels and educating EEG researchers and practitioners about IC interpretation, and (3) the automated ICLabel classifier. The classifier improves upon existing methods in two ways: by improving the accuracy of the computed label estimates and by enhancing its computational efficiency. The ICLabel classifier outperforms or performs comparably to the previous best publicly available method for all measured IC categories while computing those labels ten times faster than that classifier as shown in a rigorous comparison against all other publicly available EEG IC classifiers.
description: Intended for NeuroImage. Updated from version one with minor editorial and figure changes
ICACE-Chloride-Diffusion-Coefficient-Paper.pdf
Creators: name: Naqib Mashrur
Publisher: name: figshare
Year: 2019
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Predicting service life is an essential aspect of long-term sustainability of any reinforced concrete (RC) infrastructure in a marine environment. The service life of RC is primarily affected by chloride induced corrosion of embedded reinforcement and the consequent degradation of concrete. One of the major factors that have a pronounced effect on the degree of chloride induced corrosion is the chloride diffusion coefficient of concrete which represents the ability of concrete to resist chloride penetration. The chloride diffusion coefficients for concrete with different types of cement are available in few codes and literature. Those values could be used for predicting service life for similar concrete structure. However, diffusion coefficient largely depends on concrete mix proportions, local construction practice and materials. Therefore, it is of immense importance to evaluate the diffusion coefficient of various local mixes for predicting the service life of concrete infrastructure of Bangladesh. This prompted an investigation of the diffusion coefficients of some common concrete mixes of Bangladesh. Rapid Migration Test (RMT) has been used to achieve this end. The code NT BUILD 492 has been followed to perform the non-steady state migration test. The coefficients thus determined demonstrate that cement mixes using PCC cement are superior to their OPC counterparts in terms of durability. Similarly mixes prepared with stone aggregates show better resistance to chloride diffusion than those prepared with brick aggregate.
Metal-free cross-dehydrogenative C–N coupling of azoles with xanthenes and related activated arylmethylenes
Creators: name: Li, Yanni
name: Li, Yanping
name: Li, Yuan
name: Chen, Chunlin
name: Ying, Fengyuan
name: Dong, Ying
name: Liang, Deqiang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: A metal-free C(sp3)–H/N–H cross-coupling of azoles with xanthenes and related activated arylmethylenes is presented. Both the use of azoles and the activation pattern of C(sp3)–H sources are essential for this transformation. In the presence of 2.0 equiv of benzoyl peroxide (BPO), methylenes bearing a heteroatom-bridged bisaryl group reacted with various azolic N–H sources to afford C–N bond forming products in usually excellent or quantitative yields, and the diphenylmethane and methylenes coactivated by a phenyl group and an adjacent heteroatom are less reactive. Mechanistic investigations suggest that a radical/radical cross-coupling pathway might be involved.
Octodrilus bihariensis subsp. bihariensis bihariensis Pop 1989
Creators: name: Szederjesi, T.
name: Pop, V. V.
name: Csuzdi, C.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Crassiclitellata
Lumbricidae
Octodrilus
Octodrilus bihariensis
Octodrilus bihariensis bihariensis pop, 1989

description: Octodrilus bihariensis bihariensis Pop, 1989
 Octodrilus bihariensis bihariensis Pop, 1989: 199, Pop et al. 2012: 64.
MaterialeXamined. HNHM/16735 3 eX., ApuseniMts, Padiş, PoianaPonor, leg. Cs.
Csuzdi, J. Kontschán, V. V. Pop, Zs. Ujvári, 25.10.2009.
Remark. Thepresentmaterialisfromthetypelocality.
description: Published as part of Szederjesi, T., Pop, V. V. & Csuzdi, C., 2014, New And Little Known Earthworm Species From Peripheral Areas Of The Romanian Carpathians (Oligochaeta, Lumbricidae), pp. 85-107 in Acta Zoologica Academiae Scientiarum Hungaricae 60 (2) on pages 101-102, DOI: 10.5281/zenodo.5736316
Product User Manual for Sea Level Reprocessed In Situ Product INSITU_GLO_PHY_SSH_DISCRETE_MY_013_053
Creators: name: Pérez Gómez, Begoña
name: Lin-Ye, Jue
name: Gallardo, Alex
name: In Situ Tac Partners,
Publisher: name: Copernicus Marine In Situ TAC
Year: 2024

description: This document is the user manual of the Sea Level REProcessed In Situ product, INSITU_GLO_PHY_SSH_DISCRETE_MY_013_053, distributed by the Copernicus Marine Service In Situ Thematic Assembly Centre (In Situ TAC). It contains a description of the product, including how it is built, datasets, available data access services, and instructions for use of files and services. The Sea Level REP product is a global product that provides the best available version of in-situ historical sea level observations, reprocessed and validated in delayed mode at centralized level by the Production Centre. This is required for assessment of operational models and reanalysis, and for use by the research community. It integrates the in-situ sea level observations, mainly from tide gauges providing coastal sea level, aggregated from the Regional EuroGOOS consortium (Arctic-ROOS, BOOS, NOOS, IBIROOS, MONGOOS and Black Sea GOOS), National Data Centers (NODC’s), Hydrographic Offices or Metoffices, the Global Sea Level Observing System (GLOSS) and EMODnet Physics. The Copernicus Marine Service is not contributing to the maintenance and setting up of the observing systems it uses. The complete list of variables distributed by the In Situ TAC can be found in the Copernicus Marine In Situ TAC physical parameters list (https://doi.org/10.13155/53381). The product is updated twice a year after a delayed mode quality control and processing which includes visualization, computation of non-tidal residuals and hourly data, and check of datum stability by means of neighbour test or buddy-checking. Details are provided in the Quality Information Document (QuID) CMEMS-INS-QUID-013_053. Sea level data are available at the dedicated directory for sea level INSITU_GLO_PHY_SSH_DISCRETE_MY_013_053 of Copernicus Marine Service Dissemination System. It includes three different datasets: the first one contains the diverse original time sampling data available at the In Situ TAC NRT, which vary from 1-min to 1 hour, with updated quality control flags; a second one contains the homogeneous hourly data timeseries, validated and filtered from higher frequency observations, when available; and the third one contains an hourly dataset including astronomical tide and surge/non-tidal residuals for the IBI region. More detailed information can be obtained from the Copernicus Marine Service Copernicus Marine Service web page (https://marine.copernicus.eu/), and the In Situ TAC web page (http://www.marineinsitu.eu/). Information on operational issues on products and services can be found on our User Notification Service. If you have any questions, please contact us.
FEELVOS: Fast End-to-End Embedding Learning for Video Object Segmentation
Creators: name: Voigtlaender, Paul
name: Chai, Yuning
name: Schroff, Florian
name: Adam, Hartwig
name: Leibe, Bastian
name: Chen, Liang-Chieh
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Many of the recent successful methods for video object segmentation (VOS) are overly complicated, heavily rely on fine-tuning on the first frame, and/or are slow, and are hence of limited practical use. In this work, we propose FEELVOS as a simple and fast method which does not rely on fine-tuning. In order to segment a video, for each frame FEELVOS uses a semantic pixel-wise embedding together with a global and a local matching mechanism to transfer information from the first frame and from the previous frame of the video to the current frame. In contrast to previous work, our embedding is only used as an internal guidance of a convolutional network. Our novel dynamic segmentation head allows us to train the network, including the embedding, end-to-end for the multiple object segmentation task with a cross entropy loss. We achieve a new state of the art in video object segmentation without fine-tuning with a J&F measure of 71.5% on the DAVIS 2017 validation set. We make our code and models available at https://github.com/tensorflow/models/tree/master/research/feelvos.
description: CVPR 2019 camera-ready version
Additional file 1 of Left atrial conduit strain derived from cardiac magnetic resonance is an independent predictor of left ventricular reverse remodeling in patients with nonischemic cardiomyopathy
Creators: name: Chen, Ke
name: Chang, Lei
name: Huang, Rong
name: Wang, Ziyan
name: Mu, Dan
name: Wang, Lian
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1: Supplementary Table 1. Inter- and intraobserver agreement for LA strain
Octodrilus compromissus subsp. compromissus Zicsi et Pop 1984
Creators: name: Szederjesi, T.
name: Pop, V. V.
name: Csuzdi, C.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Crassiclitellata
Lumbricidae
Octodrilus
Octodrilus compromissus
Octodrilus compromissus compromissus zicsi et pop, 1984

description: Octodrilus compromissus compromissus Zicsi et Pop, 1984
 Octodrilus compromissus Zicsi & Pop, 1984: 245.
 Octolasium lissaense: Pop 1949: 466.
 Octodrilus compromissus compromissus: Pop 1989: 202, Pop et al. 2012: 64.
 Octodrilus compromissus: Mršić 1991: 389, Csuzdi & Pop 2008 b: 151.
MaterialeXamined. HNHM/16221 2 eX., Oltenia, nearRuncu, beechforest, 409 m, N45°10.429’ E23°08.090’, leg. Cs. Csuzdi, J. Kontschán, V. V. Pop, 28.10.2007. HNHM/16229 1 eX., Oltenia, Dâmbova, oak-hornbeammiXedforest, 458 m, N44°56.995’ E23°11.667’, leg. Cs. Csuzdi, J. Kontschán, V. V. Pop, 30.10.2007. HNHM/16172 2 eX., HNHM/16247 3 eX., HNHM/16256 3 eX., Transylvania, afterZoreniideVale, meadow, 303 m, N46°48.144’ E24°09.368’, leg. Cs. Csuzdi, J. Kontschán, V. V. Pop, 03.11.2007. HNHM/16287 1 eX., MaramureşMts, Borşa, BăileBorşa, brooksandrocksbetweenStanchihutandMt. Cearcănul, 1687 m, N47°39.801’ E24°52.663’, leg. Cs. Csuzdi, L. Dányi, J. Kontschán, D. Murányi, 22.05.2007.
 Remark. Oc. compromissus is a polytypic species (CSUZDI & POP 2006). Our presentspecimensbelongtothetypicalsubspecies.
description: Published as part of Szederjesi, T., Pop, V. V. & Csuzdi, C., 2014, New And Little Known Earthworm Species From Peripheral Areas Of The Romanian Carpathians (Oligochaeta, Lumbricidae), pp. 85-107 in Acta Zoologica Academiae Scientiarum Hungaricae 60 (2) on page 102, DOI: 10.5281/zenodo.5736316
Extended Lyman Alpha Emission Around Young Quasars: a Constraint on Galaxy Formation
Creators: name: Haiman, Zoltan
name: Rees, Martin J.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The early stage in the formation of a galaxy inevitably involves a spatially extended distribution of infalling, cold gas. If a central luminous quasar turned on during this phase, it would result in significant extended Lyman alpha emission, possibly accompanied by other lines. For halos condensing at redshifts between 3 < z < 8 and having virial temperatures between 2 x 10^5 K and 2 x 10^6 K, this emission results in a ``fuzz'' of characteristic angular diameter of a few arcseconds, and surface brightness between 10^-18 and 10^-16 erg/s/cm^2/asec^2. The fuzz around bright, high redshift quasars could be detected in deep narrow band imaging with current telescopes, providing a direct constraint on galaxy formation models. The absence of detectable fuzz might suggest that most that most of the protogalaxy's gas settles to a self-gravitating disk before a quasar turns on. However, continued gas infall from large radii, or an on-going merger spreading cold gas over a large solid angle, during the luminous quasar phase could also result in extended Ly$α$ emission, and can be constrained by deep narrow band imaging.
description: ApJ accepted version, with improved discussion of observations
Expedition: A Time-Aware Exploratory Search System Designed for Scholars
Creators: name: Singh, Jaspreet
name: Nejdl, Wolfgang
name: Anand, Avishek
Publisher: name: arXiv
Year: 2018
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Archives are an important source of study for various scholars. Digitization and the web have made archives more accessible and led to the development of several time-aware exploratory search systems. However these systems have been designed for more general users rather than scholars. Scholars have more complex information needs in comparison to general users. They also require support for corpus creation during their exploration process. In this paper we present Expedition - a time-aware exploratory search system that addresses the requirements and information needs of scholars. Expedition possesses a suite of ad-hoc and diversity based retrieval models to address complex information needs; a newspaper-style user interface to allow for larger textual previews and comparisons; entity filters to more naturally refine a result list and an interactive annotated timeline which can be used to better identify periods of importance.
Additional file 1 of Clinical option of pemetrexed-based versus paclitaxel-based first-line chemotherapeutic regimens in combination with bevacizumab for advanced non-squamous non-small-cell lung cancer and optimal maintenance therapy: evidence from a meta-analysis of randomized control trials
Creators: name: Huang, Le-Tian
name: Cao, Rui
name: Wang, Yan-Ru
name: Sun, Li
name: Zhang, Xiang-Yan
name: Guo, Yi-Jia
name: Zhao, Jian-Zhu
name: Zhang, Shu-Ling
name: Jing, Wei
name: Song, Jun
name: Han, Cheng-Bo
name: Ma, Jietao
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Pharmacology
Cancer
Hematology

description: Additional file 1:. A list of excluded papers after reading titles and abstracts.
Octodrilus parvivesiculatus Csuzdi, Pop et Pop 2011
Creators: name: Szederjesi, T.
name: Pop, V. V.
name: Csuzdi, C.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Crassiclitellata
Lumbricidae
Octodrilus
Octodrilus parvivesiculatus

description: Octodrilus parvivesiculatus Csuzdi, Pop et Pop, 2011
 Octodrilus parvivesiculatus Csuzdi, Pop & Pop, 2011: 5, Pop et al. 2012: 64.
MaterialeXamined. HNHM/16453 1 eX., RodneiMts, Borşa- StaţiuneaBorşa, Cimpoies valley, beechforest, wetgrasslandandbrooksinthevicinityofthemineralwaterspring, 1023 m, N47°36.187’ E24°46.500’, leg. L. Dányi, J. Kontschán, D. Murányi, 26.09.2006.
description: Published as part of Szederjesi, T., Pop, V. V. & Csuzdi, C., 2014, New And Little Known Earthworm Species From Peripheral Areas Of The Romanian Carpathians (Oligochaeta, Lumbricidae), pp. 85-107 in Acta Zoologica Academiae Scientiarum Hungaricae 60 (2) on page 103, DOI: 10.5281/zenodo.5736316
Tackling the pandemic challenges through bioinformatics: novel tools and approaches
Creators: name: Psomopoulos, Fotis
Publisher: name: Zenodo
Year: 2022
Subjects: subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: SARS-CoV-2
subject: Data analysis
subject: Data Modelling

description: A short presentation on the challenges and approaches of the pandemic era that are being addressed by bioinformatics. Specifically, addressing: genomic surveillance and data deposition, genomic wastewater surveillance, and strain evolution through mutation tracking.
Genotype-phenotype variability in Chinese cases of Treacher Collins syndrome
Creators: name: Li, Xiaohong
name: Su, Yu
name: Huang, Shasha
name: Gao, Bo
name: Zhang, Dejun
name: Wang, Xiaobin
name: Gao, Qin
name: Pang, Hong
name: Zhao, Yan
name: Yuan, Yongyi
name: Dai, Pu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Background: Treacher Collins syndrome (TCS) is a clinically and genetically heterogeneous disorder of craniofacial development mainly caused by variants in TCOF1, POLR1D, and POLR1C. Objectives: This study examined the causative genes of five TCS cases. Materials and Methods: In this study, two familial cases and three sporadic cases clinically diagonsed with TCS are described. Mutational analysis in probands was performed by targeted next-generation sequencing (NGS). Mutations identified by NGS were further confirmed by Sanger sequencing or multiplex ligation-dependent probe amplification (MLPA). Results: A novel gross deletion (exons 9–13), a novel small deletion (c.381_382delAG), and two known deletions (c.4131_4135delAAAAG and c.2394_2395delAG) within TCOF1 as well as a known mutation (c.91C > T) in POLR1D were identified. These five cases exhibited high inter- and intra-familial phenotypic heterogeneity. Conclusion: This is the first report of Chinese TCS cases caused by a gross deletion within TCOF1 and mutations in POLR1D. In addition to expanding the spectrum of TCS-associated mutation in the Chinese population, our findings present the diversity of its clinical presentation. It is recommended that analyses such as NGS or MLPA capable of detecting large deletions be undertaken as a part of TCS molecular diagnosis.
Shock Acceleration of Cosmic Rays - a critical review
Creators: name: Kirk, J. G.
name: Dendy, R. O.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Motivated by recent unsuccessful efforts to detect the predicted flux of TeV gamma-rays from supernova remnants, we present a critical examination of the theory on which these predictions are based. Three crucial problems are identified: injection, maximum achievable particle energy and spectral index. In each case significant new advances in understanding have been achieved, which cast doubt on prevailing paradigms such as Bohm diffusion and single-fluid MHD. This indicates that more realistic analytical models, backed by more sophisticated numerical techniques should be employed to obtain reliable predictions. Preliminary work on incorporating the effects of anomalous transport suggest that the resulting spectrum should be significantly softer than that predicted by conventional theory.
description: 8 pages, invited review presented at the 17th ECRS, Lodz, July 2000; to appear in Journal of Physics G: Nuclear and Particle Physics
MOTS: Multi-Object Tracking and Segmentation
Creators: name: Voigtlaender, Paul
name: Krause, Michael
name: Osep, Aljosa
name: Luiten, Jonathon
name: Sekar, Berin Balachandar Gnana
name: Geiger, Andreas
name: Leibe, Bastian
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper extends the popular task of multi-object tracking to multi-object tracking and segmentation (MOTS). Towards this goal, we create dense pixel-level annotations for two existing tracking datasets using a semi-automatic annotation procedure. Our new annotations comprise 65,213 pixel masks for 977 distinct objects (cars and pedestrians) in 10,870 video frames. For evaluation, we extend existing multi-object tracking metrics to this new task. Moreover, we propose a new baseline method which jointly addresses detection, tracking, and segmentation with a single convolutional network. We demonstrate the value of our datasets by achieving improvements in performance when training on MOTS annotations. We believe that our datasets, metrics and baseline will become a valuable resource towards developing multi-object tracking approaches that go beyond 2D bounding boxes. We make our annotations, code, and models available at https://www.vision.rwth-aachen.de/page/mots.
description: CVPR 2019 camera-ready version
Trachytes adrianaea Hutu 2000
Creators: name: Kontschán, J.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Trachytidae
Trachytes
Trachytes adrianaea

description: Trachytes adrianaea Huţu, 2000
 Newrecord. Bukovina, Iedu, spruceforest, frommoss, soilandalderleaflitter, N47°39.688’, E25°06,354’, 1105 m, 01.XI.2011, CsCs- KJ-VVP-UZs.
 PreviousrecordsfromRomania. BihorMts, Padiş; Codru-MomaMts, PădureaCraiului Mts (Hu Ҷu 2000).
 Distribution. Romania.
 Remark. Endemicspecies.
description: Published as part of Kontschán, J., 2013, Species Of The Genus Trachytes Michael, 1894 (Acari: Uropodina: Trachytidae) Of Romania, pp. 321-336 in Acta Zoologica Academiae Scientiarum Hungaricae 59 (4) on page 323, DOI: 10.5281/zenodo.5736231
Magnetic helicity and fluxes in an inhomogeneous alpha squared dynamo
Creators: name: Brandenburg, A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Much work on turbulent three-dimensional dynamos has been done using triply periodic domains, in which there are no magnetic helicity fluxes. Here we present simulations where the turbulent intensity is still nearly homogeneous, but now there is a perfect conductor boundary condition on one end and a vertical field or pseudo-vacuum condition on the other. This leads to migratory dynamo waves. Good agreement with a corresponding analytically solvable alpha^2 dynamo is found. Magnetic helicity fluxes are studied in both types of models. It is found that at moderate magnetic Reynolds numbers, most of the magnetic helicity losses occur at large scales. Whether this changes at even larger magnetic Reynolds numbers, as required for alleviating the catastrophic dynamo quenching problem, remains still unclear.
description: 11 pages, figures, 2 tables, Astron. Nachr. (in press)
The Broken Windows Theory in Software Engineering: An experiment on technical debt propagation
Creators: name: Levén, William
name: Broman, Hampus
Publisher: name: Zenodo
Year: 2021
Subjects: software engineering
technical debt
broken windows theory
contagious
spread
controlled experiment
Bayesian data analysis
thematic analysis
software

description: Context: The term technical debt (TD) describes the aggregation of sub-optimal solutions that serve to impede the evolution and maintenance of a system. Some claim that the broken windows theory (BWT), a concept borrowed from criminology, applies to software development projects. The theory states that the presence of indications of previous crime (such as a broken window) will increase the likelihood of further criminal activity; TD could be considered the broken windows of software systems. Objective: To empirically investigate the causal relationship between the TD density of a system and the propensity of developers to introduce new TD during the extension of that system. Primarily in situations where there are no significant hurdles to implementing a low TD solution (i.e., when there is no TD that practically forces the implementation of new TD). Method: The study used a mixed-methods strategy consisting of a controlled experiment and accompanying follow-up interviews. The experiment had a total of 29 developers of varying experience levels complete small system extension tasks in systems with high or low TD density; most subjects completed one of each for a total of 51 solution submissions. The solutions were scanned for TD, both manually and using SonarQube. A subset of subjects volunteered to participate in interviews, the results of which were evaluated using thematic analysis. Result: Bayesian data analysis revealed significant effects of TD level on the subjects’ tendency to reimplement (rather than reuse) functionality, choose nondescriptive variable names, and introduce other code smells identified by SonarQube, all with at least 95% certainty. Additionally, subjects appeared to be, at least partially, aware of when they had introduced TD. The results of the thematic analysis were in line with the findings of the experiment. Conclusion: Three separate significant results along with a validating qualitative result combine to form substantial evidence of the BWTs applicability to software engineering contexts.
Additional file 1 of Shikonin reactivates TSGs GADD45B and PPP3CC to block NSCLC cell proliferation and migration through JNK/P38/MAPK signaling pathways
Creators: name: Zhao, Yujia
name: Wu, Dan
name: Fu, Zhenkai
name: Liu, Wenna
name: Yao, Yu
name: Liang, Ying
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells
Creators: name: Cai, Na
Publisher: name: Health Research Alliance
Year: 2019
Subjects: Molecular Biology

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} The channel-kinase transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein with ion channel and kinase domains. The kinase activity of TRPM7 has been linked to the regulation of a broad range of cellular activities, but little is understood as to how the channel itself is regulated by its own kinase activity. Here, using several mammalian cell lines expressing wild-type TRPM7 or kinaseinactive variants, we discovered that compared with the cells expressing wildtype TRPM7, cells in which TRPM7’s kinase activity was inactivated had faster degradation, elevated ubiquitination, and increased intracellular retention of the channel. Mutational analysis of TRPM7 autophosphorylation sites further revealed a role for Ser-1360 of TRPM7 as a key residue mediating both TRPM7 stability and intracellular trafficking. Additional trafficking roles were uncovered for Ser-1403 and Ser-1567, whose phosphorylation by TRPM7’s kinase activity mediated the interaction of the channel with the signaling protein 14-3-3θ. In summary, our results point to a critical role for TRPM7's kinase activity in regulating proteasomemediated turnover of the TRPM7 channel and controlling its cellular localization in polarized epithelial cells. Overall, these findings improve our understanding of the significance of TRPM7’s kinase activity for functional regulation of its channel activity.
The direct Cu NQR Study of the Stripe Phase in the Lanthanum Cuprates
Creators: name: Teitel'baum, G. B.
name: Buechner, B.
name: de Gronckel, H.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Using Cu NQR in Eu-doped La_(2-x)Sr_xCuO_4 we find the evidence of the pinned stripe phase at 1.3K for 0.08 0.18 correlating with the onset of bulk superconductivity corresponds to the depinning of the stripe phase.
description: 4 pages, 3 figures, to appear in Physica C, Proceedings of the 6th International Conference on Materials and Mechanisms of Superconductivity, Houston, February 2000
Trachytes augusta Hutu 2000
Creators: name: Kontschán, J.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Trachytidae
Trachytes
Trachytes augusta

description: Trachytes augusta Huţu, 2000
 PreviousrecordsfromRomania. RetezatNationalPark (Hu Ҷu 2000).
 Distribution. Romania.
 Remark. Endemicspecies.
description: Published as part of Kontschán, J., 2013, Species Of The Genus Trachytes Michael, 1894 (Acari: Uropodina: Trachytidae) Of Romania, pp. 321-336 in Acta Zoologica Academiae Scientiarum Hungaricae 59 (4) on page 323, DOI: 10.5281/zenodo.5736231
IJBS 2018.pdf
Creators: name: Weibin Guo
name: Chaoqun Zhu
name: Zhiyong Yin
name: Qiurong Wang
name: Mingming Sun
name: Huojun Cao
name: Greaser, Marion L.
Publisher: name: Health Research Alliance
Year: 2019
Subjects: subject: 60405 Gene Expression (incl. Microarray and other genome-wide approaches)
subject: FOS: Biological sciences
subject: Cardiology
subject: Cell Biology

description: RNA binding motif 20 (RBM20) regulates pre-mRNA splicing of over thirty genes, among which titin is a major target. With RBM20 expression, titin expresses a larger isoform at fetal stage to a smaller isoform at adult resulting from alternative splicing, while, without RBM20, titin expresses exclusively a larger isoform throughout all ages. In addition to splicing regulation, it is unknown whether RBM20 also regulates gene expression. In this study, we employed Rbm20 knockout rats to investigate gene expression profile using Affymetrix expression array. We compared wild type to Rbm20 knockout at day1, 20 and 49. Bioinformatics analysis showed RBM20 regulates fewer genes expression at younger age and more at older age and commonly expressed genes have the same trends. GSEA indicated up-regulated genes are associated with heart failure. We examined titin binding partners. All titin direct binding partners are up-regulated and their increased expression is associated with dilated cardiomyopathy. Particularly, we found that genes involving calcium handling and muscle contraction are changed by RBM20. Intracellular calcium level measurement with individual cardiomyocytes further confirmed that changes of these proteins impact calcium handling. Selected genes from titin binding partners and calcium handling were validated with QPCR and western blotting. These data demonstrate that RBM20 regulates gene splicing as well as gene expression. Altered gene expression by RBM20 influences protein-protein interaction, calcium releasing and thus muscle contraction. Our results first reported gene expression impacted by RBM20 with heart maturation, and provided new insights into the role of RBM20 in the progression of heart failure.
Instabilities of wave function monopoles in Bose-Einstein condensates
Creators: name: Busch, Th.
name: Anglin, J. R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We present analytic and numerical results for a class of monopole solutions to the two-component Gross-Pitaevski equation for a two-species Bose condensate in an effectively two-dimensional trap. We exhibit dynamical instabilities involving vortex production as one species pours through another, from which we conclude that the sub-optical sharpness of potentials exerted by matter waves makes condensates ideal tools for manipulating condensates. We also show that there are two equally valid but drastically different hydrodynamic descriptions of a two-component condensate, and illustrate how different phenomena may appear simpler in each.
description: 4 pages, 9 figures (compressed figures become legible when zoomed or when paper is actually printed)
Trachytes decui Hutu 1983
Creators: name: Kontschán, J.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Trachytidae
Trachytes
Trachytes decui

description: Trachytes decui Huţu, 1983
 PreviousrecordsfromRomania. Oltenia (Hu Ҷu 1983).
 Distribution. Romania.
 Remark. Endemicspecies.
description: Published as part of Kontschán, J., 2013, Species Of The Genus Trachytes Michael, 1894 (Acari: Uropodina: Trachytidae) Of Romania, pp. 321-336 in Acta Zoologica Academiae Scientiarum Hungaricae 59 (4) on page 324, DOI: 10.5281/zenodo.5736231
Additional file 1: of Unplanned out-of-hospital birth and risk factors of adverse perinatal outcome: findings from a prospective cohort
Creators: name: FranĂ§Ois Javaudin
name: ValĂŠrie Hamel
name: Legrand, Arnaud
name: Goddet, Sybille
name: FranĂ§Ois Templier
name: Potiron, Christine
name: Pes, Philippe
name: Bagou, Gilles
name: Montassier, Emmanuel
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Population cared for by the 25 Emergency Medical Services involved in the study. (DOCX 63 kb)
Magnetization and ac susceptibility study of the cubic chiral magnet Mn$_{1-x}$Fe$_x$Si
Creators: name: Bannenberg, Lars J.
name: Weber, Frank
name: Lefering, Anton J. E.
name: Wolf, Thomas
name: Pappas, Catharine
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a comprehensive and systematic magnetization and ac susceptibility study of Mn$_{1-x}$Fe$_{x}$Si over an extensive range of ten Fe concentrations between $x$ = 0 - 0.32. With increasing Fe substitution, the critical temperature decreases but the magnetic phase diagrams remain qualitatively unaltered for $x$ $\leq$ $x^*$ $\approx$ 0.11 with clear boundaries between the helical, conical, and skyrmion lattice phase as well as an enhanced precursor phase. A notably different behavior sets in for $x$ $=$ 0.11, 0.13 and 0.14, where certain characteristics of helimagnetic correlations persist, but without clear phase boundaries. Although a qualitative change already sets in at $x^*$, the transition temperature and spontaneous magnetization vanish only at $x_C$ = 0.17 where also the average magnetic interactions change sign. Although the Curie-Weiss temperature reaches -12~K for $x$ = 0.32, no signature of long-range magnetic order is found down to the lowest temperature, indicating a possible significant role for quantum fluctuations in these systems.
Additional file 1 of Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route
Creators: name: Gao, Qiang
name: Chen, Nanxi
name: Li, Baoyi
name: Zu, Menghang
name: Ma, Ya
name: Xu, Haiting
name: Zhu, Zhenhua
name: Reis, Rui L.
name: Kundu, Subhas C.
name: Xiao, Bo
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Supplementary Material 1: Figure S1. Percentages and MFIs of DiO-labeled MLNPs internalized by L929 cells after co-incubation for 1, 3, and 5 h, respectively. Each point represents the mean ± S.E.M. (n = 3; *p < 0.05, **p < 0.01, and ***p < 0.001). Figure S2. Hemolysis test. (a) Digital photo and (b) hemolysis rates of erythrocytes with the treatment of Triton X-100 (positive control; 0.1%, w/v), PBS (negative control), and MLNPs (various protein concentrations). Each point represents the mean ± S.E.M. (n = 3). Figure S3. (a) Body weight and (b) organ index of different mouse groups. The amounts of (c) ALT, (d) AST, (e) TBIL, (f) GGT, (g) CRE, and (h) BUN in the serum from different mouse groups. Each point represents the mean ± S.E.M. (n = 3; *p < 0.05). Figure S4. Blood test results from mice with different treatments. Each point represents the mean ± S.E.M. (n = 3; *p < 0.05). Figure S5. Histological analysis of the five principle organs (heart, liver, spleen, lung, and kidney) from the mice with the treatment of MLNPs via i.v. and oral routes (Scale bar = 200 µm, n = 3). Figure S6. (a) The organ index and (b) histological analysis of the four principle organs (heart, spleen, lung, and kidney) from mice with different treatments (Scale bar = 200 µm). Each point represents the mean ± S.E.M. (n = 5)
Quantum simulation of scattering in the quantum Ising model
Creators: name: Gustafson, Erik
name: Meurice, Yannick
name: Unmuth-Yockey, Judah
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss real time evolution for the quantum Ising model in one spatial dimension with $N_s$ sites. In the limit where the nearest neighbor interactions $J$ in the spatial directions are small, there is a simple physical picture where qubit states can be interpreted as approximate particle occupations. Using exact diagonalization, for initial states with one or two particles, we show that for small $J$, discrete Bessel functions provide very accurate expressions for the evolution of the occupancies corresponding to initial states with one and two particles. Boundary conditions play an important role when the evolution time is long enough. We discuss a Trotter procedure to implement the evolution on existing quantum computers and discuss the error associated with the Trotter step size. We discuss the effects of gate and measurement errors on the evolution of one and two particle states using 4 and 8 qubits circuits approximately corresponding to existing or near term quantum computers.
description: 13 pages, 12 figures
Local magnetism of isolated Mo atoms at substitutional and interstitial sites in Yb metal : Experiment and Theory
Creators: name: Tulapurkar, A. A.
name: Mishra, S. N.
name: Pillay, R. G.
name: Salunke, H. G.
name: Das, G. P.
name: Cottenier, S.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: Using TDPAD experiment and local spin density calculations, we have observed large 4d moments on isolated Mo atoms at substitutional and octahedral interstitial lattice sites in Yb metal, showing Curie-Weiss local susceptibility and Korringa like spin relaxation rate. As a surprising feature, despite strong hybridization with the Yb neighbours, interstitial Mo atoms show high moment stability with small Kondo temperature. While, magnetism of Mo, at substitutional site is consistent with Kondo type antiferromagnetic d-sp exchange interaction, we suggest that moment stability at the interstitial site is strongly influenced by ferromagnetic polarization of Yb-4f5d band electrons.
description: 4 pages, 4 figures
The Little-Parks effect in an inhomogeneous superconducting ring
Creators: name: Nikulov, A. V.
name: Zhilyaev, I. N.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: An inhomogeneous superconducting ring placed in a magnetic field is considered. It is shown that the superconducting transition of the section with lowest critical temperature may be a first order phase transition if the magnetic flux contained within the ring is not divisible by the flux quantum. In the visinity of this transition, thermal fluctuations can induce the direct voltage in the ring with rather small sizes. The voltage value depends in a periodic manner on the magnetic flux contained within the ring. According to this result, the entropy value can be decreased in the considered quantum system. The chaotic heat energy can be transformed in the electric energy of the direct current.
description: 9 pages, LaTex, 0 figures
Additional file 3: of FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
Creators: name: Kremer, Laurent
name: Taleb, Omar
name: Boehm, Nelly
name: Ayikoe Mensah-Nyagan
name: Trifilieff, Elisabeth
name: JĂŠrĂ´Me Seze
name: Brun, Susana
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Figure S3. Effect of FTY720 on the body weight of c-EAN and EAN rats. Clinical score values were measured in vehicle (white circle, white square) and FTY720-treated (black circle, black square) rats. Therapeutic injections of FTY720 or vehicle were administrated intraperitoneally from 12 to 30â days post-immunization (dpi). Mean values and SEM are indicated. (PDF 17 kb)