cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MICROBIOLOGICAL AND IMMUNOLOGICAL FEATURES OF MULTIFORM EXUDATIVE ERYTHEMA OF THE MOUTH
Creators: name: Kh.P., Kamilov
name: K.A., Takhirova
name: O.D., Ibragimov
name: A.Z., Komilova
Publisher: name: Zenodo
Year: 2023

description: This study aimed to optimize the treatment of patients with exudative erythema multiforme (EM) by comparing traditional therapy with the addition of laser irradiation using photodynamic therapy (PDT). A total of 64 patients with EM participated in the study, and their clinical courses and risk factors for oral mucosa lesions were analyzed. The main group received local and general treatments, including lidocaine gel, chlorhexidine solution, and PDT, while the comparison group received traditional treatment. The effectiveness of therapy was assessed using a 3-point system based on subjective sensations and clinical symptoms. No side effects or complications were identified during the treatments. The results showed that patients in the main group experienced a significant reduction in clinical manifestations of EM compared to those in the comparison group. The average intensity of symptoms decreased by nearly 2 times on the 5th day and more than 11 times on the 15th day in the main group, whereas the reduction was 4 times and 8 times, respectively, in the comparison group. These findings suggest that the addition of laser irradiation using PDT to the treatment regimen may improve the outcomes for patients with exudative erythema multiforme. Further research is warranted to validate these results and explore the long-term effects of this approach.
Genome-wide insights into population structure and host specificity of Campylobacter jejuni
Creators: name: Epping, Lennard
name: Walther, Birgit
name: Piro, Rosario M.
name: Knüver, Marie-Theres
name: Huber, Charlotte
name: Thürmer, Andrea
name: Flieger, Antje
name: Fruth, Angelika
name: Janecko, Nicol
name: Wieler, Lothar H.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Computational biology and bioinformatics
subject: Ecology
subject: FOS: Biological sciences
subject: Microbiology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to host species' guts are not fully understood. In order to identify putative determinants influencing host preferences of distinct lineages, bootstrapping based on stratified random sampling combined with a k-mer-based genome-wide association was conducted on 490 genomes from diverse origins in Germany and Canada. We show a strong association of both the core and the accessory genome characteristics with distinct host animal species, indicating multiple adaptive trajectories defining the evolution of C. jejuni lifestyle preferences in different ecosystems. Here, we demonstrate that adaptation towards a specific host niche ecology is most likely a long evolutionary and multifactorial process, expressed by gene absence or presence and allele variations of core genes. Several host-specific allelic variants from different phylogenetic backgrounds, including dnaE, rpoB, ftsX or pycB play important roles for genome maintenance and metabolic pathways. Thus, variants of genes important for C. jejuni to cope with specific ecological niches or hosts may be useful markers for both surveillance and future pathogen intervention strategies.
The B cell response of the mouse to antigens of a live Salmonella Typhimurium vaccine
Creators: name: Mackie, Eleanor Bergen, 1937-
Publisher: name: University of Calgary
Year: 1986
Subjects: subject: QR 201 T9 M22 1987
subject: Micro-organisms, Pathogenic
subject: B cells
subject: Typhoid fever

description: Bibliography: p. 167-181.
The large extracellular loop of CD63 interacts with gp41 of HIV-1 and is essential for establishing the virological synapse
Creators: name: Ivanusic, Daniel
name: Madela, Kazimierz
name: Bannert, Norbert
name: Denner, Joachim
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Cell biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Human immunodeficiency virus type 1 (HIV-1)
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Human immunodeficiency virus type 1 (HIV-1) persists lifelong in infected individuals and has evolved unique strategies in order to evade the immune system. One of these strategies is the direct cell-to-cell spread of HIV-1. The formation of a virological synapse (VS) between donor and target cell is important for this process. Tetraspanins are cellular proteins that are actively involved in the formation of a VS. However, the molecular mechanisms of recruiting host proteins for the cell–cell transfer of particles to the VS remains unclear. Our study has mapped the binding site for the transmembrane envelope protein gp41 of HIV-1 within the large extracellular loop (LEL) of CD63 and showed that this interaction occurs predominantly at the VS between T cells where viral particles are transferred. Mutations within the highly conserved CCG motif of the tetraspanin superfamily abrogated recruiting of expressed HIV-1 GFP fused Gag core protein and CD63 to the VS. This demonstrates the biological significance of CD63 for enhanced formation of a VS. Since cell–cell spread of HIV-1 is a major route of persistent infection, these results highlight the central role of CD63 as a member of the tetraspanin superfamily during HIV-1 infection and pathogenesis.
Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Creators: name: Malek, Mouhannad
name: Wawrzyniak, Anna M.
name: Koch, Peter
name: Lüchtenborg, Christian
name: Hessenberger, Manuel
name: Sachsenheimer, Timo
name: Jang, Wonyul
name: Brügger, Britta
name: Haucke, Volker
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Endocytosis
subject: Lipid signalling
subject: Lipidomics
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. Here we reveal a function for calcium in the repression of cholesterol export at membrane contact sites between the ER and the Golgi complex. We show that calcium efflux from ER stores induced by inositol-triphosphate [IP3] accumulation upon loss of the inositol 5-phosphatase INPP5A or receptor signaling triggers depletion of cholesterol and associated Gb3 from the cell surface, resulting in a blockade of clathrin-independent endocytosis (CIE) of Shiga toxin. This phenotype is caused by the calcium-induced dissociation of oxysterol binding protein (OSBP) from the Golgi complex and from VAP-containing membrane contact sites. Our findings reveal a crucial function for INPP5A-mediated IP3 hydrolysis in the control of lipid exchange at membrane contact sites.
Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders
Creators: name: Gomaa, Nahla A.
name: Jimoh, Zaharadeen
name: Campbell, Sandra
name: Zenke, Julianna K.
name: Szczepek, Agnieszka J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: biomarkers
subject: inner ear
subject: cochlea
subject: audio-vestibular organ
subject: peripheral blood biomarkers
subject: functional biomarkers
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The diagnostics of inner ear diseases are primarily functional, but there is a growing interest in inner ear biomarkers. The present scoping review aimed to elucidate gaps in the literature regarding the definition, classification system, and an overview of the potential uses of inner ear biomarkers. Relevant biomarkers were categorized, and their possible benefits were evaluated. The databases OVID Medline, EMBASE, EBSCO COINAHL, CA PLUS, WOS BIOSIS, WOS Core Collection, Proquest Dissertations, Theses Global, PROSPERO, Cochrane Library, and BASE were searched using the keywords "biomarker" and "inner ear". Of the initially identified 1502 studies, 34 met the inclusion criteria. The identified biomarkers were classified into diagnostic, prognostic, therapeutic, and pathognomonic; many were detected only in the inner ear or temporal bone. The inner-ear-specific biomarkers detected in peripheral blood included otolin-1, prestin, and matrilin-1. Various serum antibodies correlated with inner ear diseases (e.g., anti-type II collagen, antinuclear antibodies, antibodies against cytomegalovirus). Further studies are advised to elucidate the clinical significance and diagnostic or prognostic usage of peripheral biomarkers for inner ear disorders, filling in the literature gaps with biomarkers pertinent to the otology clinical practice and integrating functional and molecular biomarkers. These may be the building blocks toward a well-structured guideline for diagnosing and managing some audio-vestibular disorders.
title: Children's Participation Rights in the European Union
title: The Prospect of Meaningful Policy through Images of Children
titleType: Subtitle
Creators: name: Schillmöller, Martha
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Children’s rights
subject: Child participation
subject: Recognition
subject: EU Policy
subject: Presidency of the Council of the European Union
subject: 300 Sozialwissenschaften::320 Politikwissenschaft::323 Grundrechte und politische Rechte
subject: 300 Sozialwissenschaften::320 Politikwissenschaft::327 Internationale Beziehungen

description: Children’s participation rights are among the most contentious rights enshrined in the United Nations Convention on the Rights of the Child (CRC) as they touch upon deeply rooted societal dynamics on whether children are and should be recognised as either social objects or subjects of rights. Parallelly, in the European Union (EU), the realisation of child participation hinges upon the European Commission’s limited mandate to achieve meaningful and binding child participation provisions. In this context, this thesis focuses on Member States as underestimated actors for the prospect of meaningful EU child participation policy and on how they recognise and perceive children. This thesis argues that establishing how children are perceived in three Presidencies of the Council of the EU (Romania, Germany and Finland) provides a narrow normative but necessary perspective on the prospect of meaningful EU child participation policy. More specifically, the three-dimensional concept of recognition by Axel Honneth (1995) and the figurative tool of images of children serve to establish a framework-matrix to assess child images in speeches and documents. This thesis finds that the challenge lies less in finding agreement across Member States than in realising meaningful child participation policy that understands children as subjects.
Attitudes on voluntary and mandatory vaccination against COVID-19: Evidence from Germany
Creators: name: Graeber, Daniel
name: Schmidt-Petri, Christoph
name: Schröder, Carsten
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Vaccination and immunization
subject: COVID 19
subject: Viral vaccines
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: Several vaccines against COVID-19 have now been developed and are already being rolled out around the world. The decision whether or not to get vaccinated has so far been left to the individual citizens. However, there are good reasons, both in theory as well as in practice, to believe that the willingness to get vaccinated might not be sufficiently high to achieve herd immunity. A policy of mandatory vaccination could ensure high levels of vaccination coverage, but its legitimacy is doubtful. We investigate the willingness to get vaccinated and the reasons for an acceptance (or rejection) of a policy of mandatory vaccination against COVID-19 in June and July 2020 in Germany based on a representative real time survey, a random sub-sample (SOEP-CoV) of the German Socio-Economic Panel (SOEP). Our results show that about 70 percent of adults in Germany would voluntarily get vaccinated against the coronavirus if a vaccine without side effects was available. About half of residents of Germany are in favor, and half against, a policy of mandatory vaccination. The approval rate for mandatory vaccination is significantly higher among those who would get vaccinated voluntarily (around 60 percent) than among those who would not get vaccinated voluntarily (27 percent). The individual willingness to get vaccinated and acceptance of a policy of mandatory vaccination correlates systematically with socio-demographic and psychological characteristics of the respondents. We conclude that as far as people’s declared intentions are concerned, herd immunity could be reached without a policy of mandatory vaccination, but that such a policy might be found acceptable too, were it to become necessary.
PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases
Creators: name: Garg, Ankur
name: Roske, Yvette
name: Yamada, Shinnosuke
name: Uehata, Takuya
name: Takeuchi, Osamu
name: Heinemann, Udo
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: CCCH-type zinc finger
subject: post-transcriptional immune homoeostasis
subject: ZC3H12 ribonucleases
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The CCCH-type zinc finger (ZnF) containing ZC3H12 ribonucleases are crucial in post-transcriptional immune homoeostasis with ZC3H12A being the only structurally studied member of the family. In this study, we present a structural-biochemical characterization of ZC3H12C, which is linked with chronic immune disorders like psoriasis. We established that the RNA substrate is cooperatively recognized by the PIN and ZnF domains of ZC3H12C and analyzed the crystal structure of ZC3H12C bound to a single-stranded RNA substrate. The RNA engages in hydrogen-bonded contacts and stacking interactions with the PIN and ZnF domains simultaneously. The ZC3H12 ZnF shows unprecedented structural features not previously observed in any member of the CCCH-ZnF family and utilizes stacking interactions via a unique combination of spatially conserved aromatic residues to align the target transcript in a bent conformation onto the ZnF scaffold. Further comparative structural analysis of ZC3H12 CCCH-ZnF suggests that a trinucleotide sequence is recognized by ZC3H12 ZnF in target RNA. Our work not only describes the initial structure-biochemical study on ZC3H12C, but also provides the first molecular insight into RNA recognition by a ZC3H12 family member. Finally, our work points to an evolutionary code for RNA recognition adopted by CCCH-type ZnF proteins.
title: Evaluation of Fe-nitrides, -borides and -carbides for enhanced magnetic fluid hyperthermia with experimental study of α″-Fe₁₆N₂ and ϵ-Fe₃N nanoparticles
Creators: name: Dirba, Imants
name: Chandra, Caroline Karina
name: Ablets, Yevhen
name: Kohout, Jaroslav
name: Kmječ, Tomáš
name: Kaman, Ondrej
name: Gutfleisch, Oliver
Publisher: name: IOP Publishing
Year: 2022

description: In this work, we investigate alternative materials systems that, based on their intrinsic magnetic properties, have the potential to deliver enhanced heating power in magnetic fluid hyperthermia. The focus lies on systems with high magnetization phases, namely iron-nitrogen (Fe-N), iron-boron (Fe-B) and iron-carbon (Fe-C) compounds, and their performance in comparison to the conventionally used iron oxides, γ-Fe₂O₃, Fe₃O₄ and non-stoichiometric mixtures thereof. The heating power as a function of the applied alternating magnetic field frequency is calculated and the peak particle size with the maximum specific loss power (SLP) for each material is identified. It is found that lower anisotropy results in larger optimum particle size and more tolerance for polydispersity. The effect of nanoparticle saturation magnetization and anisotropy is simulated, and the results show that in order to maximize SLP, a material with high magnetization but low anisotropy provides the best combination. These findings are juxtaposed with experimental results of a comparative study of iron nitrides, namely α″-Fe₁₆N₂ and ϵ-Fe₃N nanoparticles, and model nanoparticles of iron oxides. The former ones are studied as heating agents for magnetic fluid hyperthermia for the first time.
Automated Glycan Assembly of Oligogalactofuranosides Reveals the Influence of Protecting Groups on Oligosaccharide Stability
Creators: name: Sabbavarapu, Narayana Murthy
name: Seeberger, Peter H.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Column chromatography
subject: Organic polymers
subject: Layers
subject: Mixtures
subject: Ethyl groups
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Galactofurans are an important structural constituent of arabinogalactan and lipopolysaccharides (LPS) ubiquitously present on the envelopes of all Mycobacteria. Key to the automated glycan assembly (AGA) of linear galactofuranosides as long as 20-mers was the identification of thioglycoside building blocks with a fine balance of stereoelectronic and steric effects to ensure the stability of oligogalactofuranoside during the synthesis. A benzoylated galactofuranose thioglycoside building block proved most efficient for oligosaccharide construction.
Protamine messenger ribonucleoprotein particles in developing trout testis cells
Creators: name: Sinclair, Gary Donald
Publisher: name: University of Calgary
Year: 1980
Subjects: subject: QP 625 N87 S54 1980 Fiche
subject: Nucleoproteins
subject: Cell differentiation
subject: Spermatogenesis

description: Bibliography: p. 184-204.
"El paisaje es una relación" : interrelational ecopoetics of the Southern Cone
Creators: name: Wilson, Mac John
Publisher: name: No Publisher Supplied
Year: 2015

description: My dissertation illuminates the ecopoetic work of three distinct poets from the Southern Cone region of South America and contends that their ecopoetry demonstrates an awareness of the interrelational reality of nonhuman-human relationships. More in particular, my dissertation focuses on the importance of place and ethics in Spanish American ecological thought. Using the support of ethical ecological thinking from such critics as Bruno Latour, Timothy Morton, and Ursula Heise, I study the poetry of the Argentine poets Juan L. Ortiz (1896 - 1978) and Alfredo Veiravé (1928 - 91) and the Chilean poet and artist Cecilia Vicuña (1948 -). Principally, I take an ecocritical approach and determine that each of these poets significantly contribute to a grossly understudied reading of Spanish American poetry: ecopoetry. With the historical backdrop of before, during, and beyond a critical era in global environmentalism movements — a time centered in the 1960s and 1970s — known in this study as the environmental turn, I frame these poets’ work chronologically as affected or not affected by the growing globalization of environmentalism. More importantly, my dissertation explores the ways in which these poets present the interconnectedness of nonhumans and humans as essential to a complete understanding of humanity’s role in both the preservation and destruction of global and local ecosystems.
Sedimentary ancient DNA reveals a threat of warming-induced alpine habitat loss to Tibetan Plateau plant diversity
Creators: name: Liu, Sisi
name: Kruse, Stefan
name: Scherler, Dirk
name: Ree, Richard H.
name: Zimmermann, Heike H.
name: Stoof-Leichsenring, Kathleen R.
name: Epp, Laura S.
name: Mischke, Steffen
name: Herzschuh, Ulrike
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Biodiversity
subject: Climate-change ecology
subject: Palaeoclimate
subject: Palaeoecology
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Studies along elevational gradients worldwide usually find the highest plant taxa richness in mid-elevation forest belts. Hence, an increase in upper elevation diversity is expected in the course of warming-related treeline rise. Here, we use a time-series approach to infer past taxa richness from sedimentary ancient DNA from the south-eastern Tibetan Plateau over the last ~18,000 years. We find the highest total plant taxa richness during the cool phase after glacier retreat when the area contained extensive and diverse alpine habitats (14–10 ka); followed by a decline when forests expanded during the warm early- to mid-Holocene (10–3.6 ka). Livestock grazing since 3.6 ka promoted plant taxa richness only weakly. Based on these inferred dependencies, our simulation yields a substantive decrease in plant taxa richness in response to warming-related alpine habitat loss over the next centuries. Accordingly, efforts of Tibetan biodiversity conservation should include conclusions from palaeoecological evidence.
Cosmogenic in situ 14C-10Be reveals abrupt Late Holocene soil loss in the Andean Altiplano
Creators: name: Hippe, Kristina
name: Jansen, John D.
name: Søndergaard Skov, Daniel
name: Lupker, Maarten
name: Ivy-Ochs, Susan
name: Kober, Florian
name: Zeilinger, Gerold
name: Capriles, José Mariano
name: Christl, Marcus
name: Maden, Colin
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Environmental impact
subject: Geomorphology
subject: Andean Altiplano
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Soil sustainability is reflected in a long-term balance between soil production and erosion for a given climate and geology. Here we evaluate soil sustainability in the Andean Altiplano where accelerated erosion has been linked to wetter climate from 4.5 ka and the rise of Neolithic agropastoralism in the millennium that followed. We measure in situ cosmogenic 14C directly on cultivated hilltops to quantify late Holocene soil loss, which we compare with background soil production rates determined from cosmogenic 26Al and 10Be. Our Monte Carlo-based inversion method identifies two scenarios to account for our data: an increase in erosion rate by 1–2 orders of magnitude between ~2.6 and 1.1 ka, or a discrete event stripping ~1–2 m of soil between ~1.9 and 1.1 ka. Coupled environmental and cultural factors in the Late Holocene signaled the onset of the pervasive human imprint in the Andean Altiplano seen today.
A dictionary and grammatical sketch of Dagaare
Creators: name: Ali, Mark
name: Grimm, Scott
name: Bodomo, Adams
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Dagaare language
subject: Upper West region of Ghana
subject: Central Dagaare
subject: 400 Sprache::400 Sprache::403 Wörterbücher, Enzyklopädien

description: This book presents an extensive dictionary of the Dagaare language (Niger-Congo; Gur (Mabia)), focussing on the dialect of Central Dagaare, spoken in the Upper West region of Ghana. The dictionary provides comprehensive definitions, example sentences and the English translations, phonetic forms, inflected forms, etymological notes as well as information dialectal variation. This work is intended as a resource for linguists, but also as a resource for Dagaare speakers. Also included is a grammatical sketch of Dagaare contributed by Prof. Adams Bodomo.
Sensitivity to expression levels underlies differential dominance of a putative null allele of the Drosophila tβh gene in behavioral phenotypes
Creators: name: Damrau, Christine
name: Colomb, Julien
name: Brembs, Björn
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Heterozygosity
subject: Behavior
subject: Gene expression
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The biogenic amine octopamine (OA) and its precursor tyramine (TA) are involved in controlling a plethora of different physiological and behavioral processes. The tyramine-β-hydroxylase (tβh) gene encodes the enzyme catalyzing the last synthesis step from TA to OA. Here, we report differential dominance (from recessive to overdominant) of the putative null tβhnM18 allele in 2 behavioral measures in Buridan’s paradigm (walking speed and stripe deviation) and in proboscis extension (sugar sensitivity) in the fruit fly Drosophila melanogaster. The behavioral analysis of transgenic tβh expression experiments in mutant and wild-type flies as well as of OA and TA receptor mutants revealed a complex interaction of both aminergic systems. Our analysis suggests that the different neuronal networks responsible for the 3 phenotypes show differential sensitivity to tβh gene expression levels. The evidence suggests that this sensitivity is brought about by a TA/OA opponent system modulating the involved neuronal circuits. This conclusion has important implications for standard transgenic techniques commonly used in functional genetics.
title: Soziale Ungleichheit und die  Rolle sozialer Beziehungen in  der (Ganztags-)Schule
title: Kein Thema für die Fortbildung?
titleType: Subtitle
Creators: name: Betz, Tanja
name: Meyer-Hamme, Alexa
name: Halle, Arne-Christoph
Publisher: name: Bertelsmann Stiftung
Year: 2022
Subjects: Bildungsungleichheit
Benachteiligung
Armut
Schule
Lehrkräfte
Ausbildung
Fortbildung

description: Welches Wissen und welche Kompetenzen brauchen Lehr- und Fachkräfte für die gelingende Beziehungsarbeit im Kontext von sozialer Benachteiligung? Was brauchen Kinder und Jugendliche im Schulalltag von ihnen? Und welche Antworten können Fortbildung bzw. Professionalisierung hier geben? In einem Kooperationsprojekt mit Prof. Dr. Tanja Betz von der Johannes Gutenberg-Universität Mainz wurden diese Fragen bearbeitet. Die Forschungsergebnisse zeigen, dass Habitussensibilität, also die bewusste und professionelle Vergegenwärtigung von Lebenslagen, Denkmustern und Alltagskultur, in der Beziehungsarbeit eine zentrale Rolle spielt. Dieser Sammelband fasst nicht nur die Forschungsergebnisse zusammen, sondern dokumentiert auch die zentralen Beiträge eines Dialogforums im Juni 2022, auf dem über 50 Expert:innen der Aus- und Fortbildung aus den Ergebnissen Lösungsansätze für die Professionalisierung entwickelt haben.
The Efficacy of two-choice match-to-sample training procedure for increasing spontaneous imitative behaviour in mentally retarded individuals
Creators: name: Souveny, Dwaine (Dwaine Matthew), 1955-
Publisher: name: University of Calgary
Year: 1981
Subjects: subject: LC 4602 S646 1983
subject: Handicapped children - Testing
subject: Imitation in children

description: Bibliography: p. 58-66.
Soluble Pecam-1 as a Biomarker in Periprosthetic Joint Infection
Creators: name: Fuchs, Michael
name: Trampuz, Andrej
name: Kirschbaum, Stephanie
name: Winkler, Tobias
name: Sass, F. Andrea
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: biomarker
subject: TKA
subject: periprosthetic joint infection
subject: PJI
subject: revision arthroplasty
subject: diagnostic tool
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: A reliable workup with regard to a single diagnostic marker indicating periprosthetic joint infection (PJI) with sufficient sensitivity and specificity is still missing. The immunologically reactive molecule Pecam-1 is shed from the T-cell surface upon activation via proinflammatory signaling, e.g., triggered by specific pathogens. We hypothesized that soluble Pecam-1 (sPecam-1) can hence function as a biomarker of PJI. Fifty-eight patients were prospectively enrolled and assigned to one of the respective treatment groups (native knees prior to surgery, aseptic, and septic total knee arthroplasty (TKA) revision surgeries). Via synovial sample acquisition and ELISA testing, a database on local sPecam-1 levels was established. We observed a significantly larger quantity of sPecam-1 in septic (n = 22) compared to aseptic TKA revision surgeries (n = 20, p ≤ 0.001). Furthermore, a significantly larger amount of sPecam-1 was found in septic and aseptic revisions compared to native joints (n = 16, p ≤ 0.001). Benchmarking it to the gold standard showed a high predictive power for the detection of PJI. Local sPecam-1 levels correlated to the infection status of the implant, and thus bear a strong potential to act as a biomarker of PJI. While a clear role of sPecam-1 in infection could be demonstrated, the underlying mechanism of the molecule's natural function needs to be further unraveled.
Râmele – arhitecții solurilor fertile
Creators: name: Pfiffner, Lukas
Publisher: name: Zenodo
Year: 2022
Subjects: sol
biologia solului
fertilitatea solului
cultivarea solului
râmele
agricultură organică

description: Ghidul tehnic sintetizează cunoștințele despre râme. Acesta oferă o imagine de ansamblu a biologiei, ecologiei și a multiplelor servicii pe care le prestează râmele în agricultură și oferă recomandări pentru promovarea acestor organisme extraordinare în solurile agricole.
Optimal reconstruction of dynamical systems: A noise amplification approach
Creators: name: Uzal, L. C.
name: Grinblat, G. L.
name: Verdes, P. F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: In this work we propose an objective function to guide the search for a state space reconstruction of a dynamical system from a time series of measurements. This statistics can be evaluated on any reconstructed attractor, thereby allowing a direct comparison among different approaches: (uniform or non-uniform) delay vectors, PCA, Legendre coordinates, etc. It can also be used to select the most appropriate parameters of a reconstruction strategy. In the case of delay coordinates this translates into finding the optimal delay time and embedding dimension from the absolute minimum of the advocated cost function. Its definition is based on theoretical arguments on noise amplification, the complexity of the reconstructed attractor and a direct measure of local stretch which constitutes a novel irrelevance measure. The proposed method is demonstrated on synthetic and experimental time series.
description: 19 pages, 19 figures
Detrital zircon geochronology from the Nueva Segovia Schist, Nicaragua: evidence for the tectonic evolution of the Chortís Block?
Creators: name: Freeborne, Sean
name: Braid, James A.
Publisher: name: Geological Society of London
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: SF1: Sample locations
Shear Wave Elastography and Shear Wave Dispersion Imaging in the Assessment of Liver Disease in Alpha1-Antitrypsin Deficiency
Creators: name: Schulz, Marten
name: Kleinjans, Moritz
name: Strnad, Pavel
name: Demir, Münevver
name: Holtmann, Theresa M.
name: Tacke, Frank
name: Wree, Alexander
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: alpha1-antitrypsin deficiency (AATD)
subject: shear wave elastography (SWE)
subject: shear wave dispersion (SWD)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Liver affection of Alpha1-antitrypsin deficiency (AATD) can lead to cirrhosis and hepatocellular carcinoma (HCC). A noninvasive severity assessment of liver disease in AATD is urgently needed since laboratory parameters may not accurately reflect the extent of liver involvement. Preliminary data exist on two-dimensional shear wave elastography (2D-SWE) being a suitable method for liver fibrosis measurement in AATD. AATD patients without HCC were examined using 2D-SWE, shear wave dispersion imaging (SWD) and transient elastography (TE). Furthermore, liver steatosis was assessed using the controlled attenuation parameter (CAP) and compared to the new method of attenuation imaging (ATI). 29 AATD patients were enrolled, of which 18 had the PiZZ genotype, eight had PiMZ, two had PiSZ and one had a PiZP-Lowell genotype. 2D-SWE (median 1.42 m/S, range 1.14-1.83 m/S) and TE (median 4.8 kPa, range 2.8-24.6 kPa) values displayed a significant correlation (R = 0.475, p < 0.05). 2D-SWE, ATI (median 0.56 dB/cm/MHz, range 0.43-0.96 dB/cm/MHz) and CAP (median 249.5 dB/m, range 156-347 dB/m) values were higher in PiZZ when compared to other AATD genotypes. This study provides evidence that 2D-SWE is a suitable method for the assessment of liver disease in AATD. The newer methods of SWD and ATI require further evaluation in the context of AATD.
The Nature of Hypervelocity Stars and the Time Between Their Formation and Ejection
Creators: name: Brown, Warren R.
name: Cohen, Judith G.
name: Geller, Margaret J.
name: Kenyon, Scott J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We obtain Keck HIRES spectroscopy of HVS5, one of the fastest unbound stars in the Milky Way halo. We show that HVS5 is a 3.62 +- 0.11 Msun main sequence B star at a distance of 50 +- 5 kpc. The difference between its age and its flight time from the Galactic center is 105 +-18(stat)+-30(sys) Myr; flight times from locations elsewhere in the Galactic disk are similar. This 10^8 yr `arrival time' between formation and ejection is difficult to reconcile with any ejection scenario involving massive stars that live for only 10^7 yr. For comparison, we derive arrival times of 10^7 yr for two unbound runaway B stars, consistent with their disk origin where ejection results from a supernova in a binary system or dynamical interactions between massive stars in a dense star cluster. For HVS5, ejection during the first 10^7 yr of its lifetime is ruled out at the 3-sigma level. Together with the 10^8 yr arrival times inferred for three other well-studied hypervelocity stars (HVSs), these results are consistent with a Galactic center origin for the HVSs. If the HVSs were indeed ejected by the central black hole, then the Galactic center was forming stars ~200 Myr ago, and the progenitors of the HVSs took ~100 Myr to enter the black hole's loss cone.
description: 6 pages, accepted to ApJ Letters
Chalcogenide optical parametric oscillator
Creators: name: Ahmad, Raja
name: Rochette, Martin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate the first optical parametric oscillator (OPO) based on chalcogenide glass. The parametric gain medium is an As2Se3 chalcogenide microwire coated with a layer of polymer. The doubly-resonant OPO oscillates simultaneously at a Stokes and an anti Stokes wavelength shift of >50 nm from the pump wavelength that lies at λP = 1552 nm. The oscillator has a peak power threshold of 21.6 dBm and a conversion efficiency of >19 %. This OPO experiment provides an additional application of the chalcogenide microwire technology; and considering the transparency of As2Se3 glass extending far in the mid-infrared (mid-IR) wavelengths, the device holds promise for realizing mid IR OPOs utilizing existing optical sources in the telecommunications wavelength region.
Simulation of polarization data using modified Glazounov equation (T & E simultaneously) of barium titanate based normal and relaxor ferroelectrics
Creators: name: Mahboob, Syed
name: Devi, Ch. Sameera
name: Rizwana
name: Prasad, G.
name: Kumar, G. S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In the present study, simulation of polarization data using modified Glazounov equation (T & E simultaneously) of Barium Titanate based normal and relaxor ferroelectrics (i.e. BaTiO3 and Ba(NdxTi(1-2x)Nbx)O3) as proposed by us was carried out. These materials were prepared through sol-gel and solid state double sintering route. Modified Glazounov equation describes and model the experimental PE data in terms of dipole moment and activation energy for thermally activated dipoles present the ceramic materials. This equation best fit to the experimental PE data. The increase and decrease of activation energy with temperature and composition was attributed to the degree of disorderness of dipoles.
Detrital zircon geochronology from the Nueva Segovia Schist, Nicaragua: evidence for the tectonic evolution of the Chortís Block?
Creators: name: Freeborne, Sean
name: Braid, James A.
Publisher: name: Geological Society of London
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: SF3: Zircon images
Fathering behavior, attachment, and engagement in childcare predict testosterone and cortisol
Creators: name: Ahnert, Lieselotte
name: Deichmann, Felix
name: Bauer, Markus
name: Supper, Barbara
name: Piskernik, Bernhard
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Attachment-Q Sort
subject: Parental Behavioral Inventory
subject: quality of father–child relationship
subject: seasonal variation in testosterone and cortisol
subject: timetable interview
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: The present study examined testosterone (T) and cortisol (Cort) in fathers engaged with caregiving. We collected saliva samples in the mornings and evenings of two consecutive days in 150 fathers of 1- to 5-year-old children. Fathers completed questionnaires on socioeconomic status, family structure and life, sleep characteristics and body mass index (BMI), and reported on their engagement in childcare. Fathers used smartphone-based experience sampling throughout 1 week to sample ongoing activities with their children, including times of supervision, joint play, rough-and-tumble play, and cuddling episodes. External observers rated father–child attachment during a home visit. We began by testing for widely characterized covariates of T and excluded seasonal variations and known predictors associated with lowered T, such as older fathers and those with multiple and young children, lower BMI, shorter sleep duration, and sexual activity before sampling. Most interestingly, however, fathers’ engagement in childcare and attachment to the child appeared more pronounced the greater the diurnal decline in T. Cuddling predicted a similar negative association, whereas joint play and rough-and-tumble play (RTP) showed enhancing effects on declining T. Interestingly, all fathering behaviors (except RTP) were positively related to lower Cort. In contrast, supervision was ineffective on both Cort and T.
Detrital zircon geochronology from the Nueva Segovia Schist, Nicaragua: evidence for the tectonic evolution of the Chortís Block?
Creators: name: Freeborne, Sean
name: Braid, James A.
Publisher: name: Geological Society of London
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: SF2: U–PB data tables
Electromechanical coupling, AC and DC resistivity simulation studies on [Ba(Nd0.075Ti0.85Nb0.075)O3]0.30 [(Na0.5Bi0.5)TiO3]0.70 piezoelectric ceramic
Creators: name: Mahboob, Syed
name: Rizwana
name: Prasad, G.
name: Kumar, G. S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: In the present study, we have prepared the [Ba(Nd0.075Ti0.85Nb0.075)O3]0.30–[(Na0.5Bi0.5)TiO3]0.70 ceramic through solid-state double sintering route. New equations which were proposed by us earlier were used to describe and model the electromechanical, AC and DC resistivity data. The activation energy for resonance and anti-resonance at 300 K is 30.28 and 30.11 meV; whereas the value is 38.32 and 38.91 meV at 448 K. The higher activation energy for AC conduction when compared to DC conduction is attributed to the fast vibration of charged polar and conducting species in response to the applied frequency, which requires more temperature.
Synthetic Spectra and Light Curves of Interacting Binaries and Exoplanets with Circumstellar Material: SHELLSPEC
Creators: name: Budaj, Jan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Program SHELLSPEC is designed to calculate light-curves, spectra and images of interacting binaries and extrasolar planets immersed in a moving circumstellar environment which is optically thin. It solves simple radiative transfer along the line of sight in moving media. The assumptions include LTE and optional known state quantities and velocity fields in 3D. Optional (non)transparent objects such as a spot, disc, stream, jet, ufo, shell or stars may be defined (embedded) in 3D and their composite synthetic spectrum calculated. Roche model can be used as a boundary condition for the radiative transfer. Recently a new model of the reflection effect, dust and Mie scattering were incorporated into the code. $ε$ Aurigae is one of the most mysterious objects on the sky. Prior modeling of its light-curve assumed dark, inclined, disk of dust with the central hole to explain the light-curve with a sharp mid-eclipse brightening. Our model consists of two geometrically thick flared disks. Internal optically thick disk and external optically thin disk which absorbs and scatters radiation. Shallow mid-eclipse brightening may result from eclipses by nearly edge-on flared (dusty or gaseous) disks. Mid-eclipse brightening may also be due to strong forward scattering and optical properties of the dust which can have an important effect on the light-curves. There are many similarities between interacting binary stars and transiting extrasolar planets. Reflection effect which is briefly reviewed is one of them. The exact Roche shape and temperature distributions over the surface of all currently known transiting extrasolar planets have been determined. In some cases (HAT-P-32b, WASP-12b, WASP-19b) departures from the spherical shape can reach 7-15%.
description: 6 pages, 2 figures, to appear in the Proceedings: From Interacting Binaries to Exoplanets: Essential Modeling Tools, IAU Symposium 282, held in Tatranska Lomnica, July 2011
Architecture For Data Management
Creators: name: Vukolic, Marko
Publisher: name: Zenodo
Year: 2015
Subjects: architecture, cloud-of-clouds, data management, dependability, security, storage

description: In this document we present the preliminary architecture of the SUPERCLOUD data management and storage. We start by defining the design requirements of the architecture, motivated by use cases and then review the state-of-the-art. We survey security and dependability technologies and discuss designs for the overall unifying architecture for data management that serves as an umbrella for different security and dependability data management features. Specifically the document lays out the architecture for data privacy, secure sharing schemes, geo-replication and fault and disaster tolerance for SUPERCLOUD data management. We further discuss our federated identity and key management approach.
Formation, dynamics and stability of coreless vortex dipoles in phase-separated binary condensates
Creators: name: Gautam, S.
name: Muruganandam, P.
name: Angom, D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the motion of the Gaussian obstacle potential created by blue detuned laser beam through a phase-separated binary condensate in pancake-shaped traps. For the velocity of the obstacle above a critical velocity, we observe the generation of vortex dipoles in the outer component which can penetrate the inner component. This is equivalent to finite, although small, transport of outer component across the inner component. In the inner component, the same method can lead to the formation of coreless vortex dipoles.
description: 12 pages, 9 figures
Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens
Creators: name: Igler, Claudia
name: Rolff, Jens
name: Regoes, Roland
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: antimicrobial treatment
subject: drug resistance
subject: resistance evolution
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat. However, most such models consider resistance emergence via a single mutational step. Here, we assembled experimental evidence that drug resistance evolution follows two patterns: (i) a single mutation, which provides a large resistance benefit, or (ii) multiple mutations, each conferring a small benefit, which combine to yield high-level resistance. Using stochastic modeling, we then investigated the consequences of these two patterns for treatment failure and population diversity under various treatments. We find that resistance evolution is substantially limited if more than two mutations are required and that the extent of this limitation depends on the combination of drug type and pharmacokinetic profile. Further, if multiple mutations are necessary, adaptive treatment, which only suppresses the bacterial population, delays treatment failure due to resistance for a longer time than aggressive treatment, which aims at eradication.
Sulfur-density differentials of crude oil: a linear programming analysis
Creators: name: Streifel, Shane S.
Publisher: name: University of Calgary
Year: 1981
Subjects: subject: HD 9560.4 S85 1983
subject: Petroleum refineries - Mathematical models
subject: Petroleum - Sulphur content
subject: Petroleum products - Prices - Mathematical models
subject: Petroleum products - Marketing - Mathematical models

description: Bibliography: p. 176-178.
Simultaneous Yeast Display for Medical Biosensors
Creators: name: Sood, Rashika
Publisher: name: Macquarie University
Year: 2023
Subjects: Other education not elsewhere classified

description: Biosensors play an important role in medical diagnostics, industrial biotechnology, and environmental monitoring. A key challenge in biosensor design is developing complementary ligand binding domains which bind to the small molecule in a sandwich like fashion, causing fused biosensor output domains to co-localise and transduce a signal. We lay the foundation of designing an in vivo system utilising yeast mating for tackling the difficult task of generating novel pairs of complementary binding domains termed as Simultaneous Yeast Display (SYD). This system relies on strains of yeast that have their native sexual agglutination ability knocked out such that mating of haploid cells to form a diploid is dependent upon interactions between heterologous expressed surface proteins. While this system has been used previously to characterise and select for proteinprotein interactions, its use in selecting protein-ligand-protein interactions has not been published. We present results showing that surface display of known ligand binding proteins causes an increase in mating efficiency upon introduction of the ligand in liquid culture. In the future, this technique can be further used to screen yeast display libraries of randomised peptides or proteins to discover novel complementary binding domains with high sensitivity and selectivity for a multitude of ligands.