cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Life-Space of Older Adults after Discharge from Skilled Nursing Facilities
Creators: name: Bankole A.O.
name: Toles M.
name: Preisser J.S.
name: Hu D.
name: Zhang Y.
name: Colón-Emeric C.
Publisher: name: Elsevier Inc.
Year: 2024

description: Objectives: Describe (1) patient or caregiver perceptions of physical function in 30 days after skilled nursing facility (SNF) discharge indicated by Life-Space Assessment (LSA) scores, and (2) patient and caregiver factors associated with LSA scores. Design: Secondary analysis of baseline and outcomes data from the cluster randomized trial of the Connect-Home transitional care intervention. Setting and Participants: Six SNFs in North Carolina. Patient and caregiver dyads with LSA scores (N = 245). Methods: SNF patients or their caregivers serving as proxy reported the life-space of the SNF patient using the LSA tool, a measure of environmental and social factors that influence physical mobility. Simple scores for highest life-space attained depending on equipment and/or caregiver support range from 0 to 5, with higher scores indicating greater mobility. Multiple linear regression models for simple LSA scores and Composite Life-Space (0-120), adjusted for treatment, time via a COVID pandemic indicator, and treatment × COVID effect as fixed effects, were used to estimate the association of patient and caregiver variables and life-space. Results: Patients had a mean age of 76.3 years, 62.6% were female, and 74.7% were white. Caregivers were commonly female (73.9%) and adult children of the patient (46.5%). The mean Composite Life-Space score was 22.6 (16.09). The mean Assisted Life-Space score (range: 0-5) was 1.6 (1.47), and 76.3% of patients could not move beyond their bedroom, house, and yard without assistance of another person. Higher Composite Life-Space scores were associated with lower levels of cognitive impairment and shorter SNF length of stay. Conclusions and Implications: SNF patients and their caregivers reported very low LSA scores in 30 days after SNF care. Findings indicate the need for care redesign to promote recovery of physical function of older adults after SNF discharge, such as optimizing SNF rehabilitative therapy and adding postdischarge rehabilitative supports at home.
Brief an Johann I Bernoulli
Creators: name: Burnet, William
Publisher: name: [s.n.]
Year: 1710
Subjects: Craig, John1663-1731

description: Burnet will Joh. B. nur mitteilen, dass Craig von seiner Lösung voll befriedigt ist und dass er bald eine Abhandlung publizieren wird, in der er Joh. B. volle Gerechtigkeit hinsichtlich seiner voreiligen Rezension widerfahren lassen wird. Er bedauert, die nötige Aufklärung nicht früher erhalten zu haben.
description: von William Burnet
description: Siegel. 2 Seiten leer
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Abschrift unter L Ia 908:Bl.183v Mitte-183v unten
Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium
Creators: name: Sempowski G.D
name: Barnett K.C.
name: Hewitt S.M
name: Ting J.P.-Y.
name: Karlsson A
name: Chou W.-C.
name: Oguin T.H
name: Nguyen T.T
name: Lenschow D.J
name: Xie Y
name: Riebe K.
name: Vannella K.M
name: Hsu M.
name: Blasi M
name: Chertow D.S
name: Liang K.
name: Bais S.S.
name: Koller B.H
name: Randell S.H.
Publisher: name: American Association for the Advancement of Science
Year: 2024

description: Virus-induced cell death is a key contributor to COVID-19 pathology. Cell death induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well studied in myeloid cells but less in its primary host cell type, angiotensin-converting enzyme 2 (ACE2)–expressing human airway epithelia (HAE). SARS-CoV-2 induces apoptosis, necroptosis, and pyroptosis in HAE organotypic cultures. Single-cell and limiting-dilution analysis revealed that necroptosis is the primary cell death event in infected cells, whereas uninfected bystanders undergo apoptosis, and pyroptosis occurs later during infection. Mechanistically, necroptosis is induced by viral Z-RNA binding to Z-DNA–binding protein 1 (ZBP1) in HAE and lung tissues from patients with COVID-19. The Delta (B.1.617.2) variant, which causes more severe disease than Omicron (B1.1.529) in humans, is associated with orders of magnitude–greater Z-RNA/ZBP1 interactions, necroptosis, and disease severity in animal models. Thus, Delta induces robust ZBP1-mediated necroptosis and more disease severity.
Brief an William Burnet
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1711
Subjects: Gravesande, Willem Jacob1688-1742
Craig, John1663-1731

description: Joh. B. hat die beiden letzten Briefe von Burnet erhalten. Er hat aus dem zweiten mit Vergnügen entnommen, dass Craig von seiner Lösung des Problems der Transformation algebraischer Kurven mittels des motus reptorius voll befriedigt ist. Er bittet Burnet, ihm Craigs gedruckte Stellungnahme sobald als möglich zu übersenden. Was die Berufung nach Leiden betrifft, so kann 'sGravesande Burnet besser über den neuesten Stand informieren. Er hat von diesem vorgestern einen Brief erhalten, aus dem er entnimmt, dass die Sache schlecht steht. 'sGravesande beginnt wieder von 1600 bis 1800 fl. zu sprechen, was völlig ungenügend ist. Joh. B. müsste mindestens 1000 ecu haben. Andernfalls kann man sich das Porto für weitere Briefe sparen.
description: von Johann I Bernoulli
description: Datum am Briefkopf eigenhändig
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Weitere Abschrift unter L Ia 908:Bl.205
Additional file 1 of scDART: integrating unmatched scRNA-seq and scATAC-seq data and learning cross-modality relationship simultaneously
Creators: name: Zhang, Ziqi
name: Yang, Chengkai
name: Zhang, Xiuwei
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 1 Supplementary figures S1-S8.
Local Health Department Values and Organizational Authorities Guiding Cross-Sector Work During COVID-19
Creators: name: Johnson K.
name: Wiesman J.
name: Valdes Lupi M.
name: Biddell C.B.
name: Hassmiller Lich K.
name: Gora Combs K.
Publisher: name: SAGE Publications Inc.
Year: 2024

description: Objective: The COVID-19 pandemic highlighted the role that local health departments (LHDs) have in cross sector can address alone, including the work of value alignment and the strategic use of organizational authorities. The practices by which LHDs used their authorities to conduct cross-sector work during the pandemic need exploration. Method: We conducted semi-structured interviews with 19 public health leaders from metropolitan LHDs across the United States. Our interview guide assessed the values that LHD leadership prioritized in their cross-sector work as well as the range of organizational authorities they leveraged to influence external decision-making in other sectors. Results: We found that LHDs approached cross-sector work by leaning on diverse values and authorities, each with unique implications for their work. The LHDs emphasized their approach to value alignment on a sector-by-sector basis, strategically using diverse organizational authorities—economic, political, moral, scientific, and logistical. While each authority and value we assessed was present across all interviewees, how each shaped action varied. Internally, LHDs emphasized certain authorities more than others to the degree that they more closely aligned with prioritized core values. Conclusion: Our findings highlight the ongoing need for LHD leadership to improve their ability to effectively communicate public health values and the unique authorities by which health-supporting work can be facilitated, including how this message must be adapted, depending on the specific sectors with which the LHD needs to partner and the governance arrangement in which the LHD is situated.
Brief an Johann I Bernoulli
Creators: name: Burnet, William
Publisher: name: [s.n.]
Year: 1711
Subjects: Gravesande, Willem Jacob1688-1742
Bernoulli, Nicolaus1687-1759
Cheyne, George1671-1743
Craig, John1663-1731
Moivre, Abraham de1667-1754
Montmort, Pierre Rémond de1678-1719
Newton, Isaac1643-1727
Obdam, d'erster Kurator der Universität Leiden

description: Burnet sendet - um Joh. B. das Porto zu sparen - nur einen Auszug aus Craigs positiver Stellungnahme in den Philos. Trans. hinsichtlich Joh. B.s motus reptorius. Der Auszug wird auch in den AE erscheinen [AE Julii 1713, 315]. Der Aufsatz enthält ein allgemeines Verfahren, Logarithmen mit den gleichen Methoden wie für die Quadraturen zu bilden. Er bedauert, dass Obdam die Hoffnungen, die man hinsichtlich Joh. B.s Berufung nach Leiden auf ihn gesetzt hatte, nicht erfüllt hat. P.S. Burnet hofft, dass es Nic. I B. gut geht und dass er ihn vielleicht einmal in England sehen kann. Burnet berichtet von Experimenten der Royal Society zum Fall verschiedener Köper vom Glockenturm der St. Paul's Cathedral, zur Luftdurchlässigkeit glühender Metalle und zur Refraktion des Lichts in Flüssigkeiten. Letztere hängt nicht von der Dichte, sondern von der Unentflammbarkeit der Flüssigkeit ab. De Moivre will ein Buch über den Zufall publizieren, das weiter geht als die französische Analyse du jeu de hazard [von Montmort]. Burnet hat sich von den Naturwissenschaften zurückgezogen zwecks Studium des englischen Rechts. Newton, Craig und Cheyne lassen grüssen. Briefe sollen immer noch an 'sGravesande in Den Haag gerichtet werden.
description: von William Burnet
description: 2 Siegel. Das Datum des Briefes enthält keine Jahresangabe. Joh. I B. hat autograph hinzugefügt: "1711. peutetre 1710." Dem Brief liegt ein gedruckter Ausschnitt aus Phil. Trans. t.27, Nr. 328 (1710), p.195 bei, in dem Craig die bereits angekündigte Ehrenrettung Joh. B.s hinsichtlich dessen motus reptorius öffentlich ausspricht. Dieses Heft der Phil. Trans. erschien frühestens im Dezember 1710. Auch bestätigt Joh. I Bernoulli im Brief von 1712 03 05 Burnet den Erhalt eines Briefes von 1711 11 20, nachdem die Korrespondenz länger unterbrochen war.
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Abschrift unter L Ia 908:Bl.182
Lupus Nephritis Kidney Biopsy Characteristics and Preterm Birth
Creators: name: Manuck, Tracy A.
name: Poulton, Caroline J.
name: Stuebe, Alison M.
name: Gibson, Keisha L.
name: Reynolds, Monica
name: Derebail, Vimal K.
name: Blazek, Lauren
name: Falk, Ronald
name: Hogan, Susan L.
Publisher: name: Frontiers Media SA
Year: 2024

description: Individuals with lupus nephritis (LN) are at high risk of adverse maternal and fetal outcomes in pregnancy. Outside of pregnancy, proliferative lesions on kidney biopsies are associated with disease progression, but these have not been consistently associated with increased risk in pregnancy. This retrospective, single-center study examines how histologic findings, the timing from kidney biopsy to pregnancy, and the clinical features in the first trimester are associated with preterm birth among individuals with LN. Among 35 deliveries in 31 women, the mean gestational age at delivery was 33.8 weeks. The presence of a urine protein-to-creatinine ratio >0.5 g/g in the first trimester was associated with preterm delivery (81% vs. 36%, p = 0.04). Preterm birth was more common in individuals with glomerular crescents on biopsy (89% in those with >20% crescents vs. 50% in those with <20%, p = 0.06). A pregnancy occurring within 2 years after a kidney biopsy was more likely to result in preterm birth than if the biopsy was performed more than 2 years prior to conception (82% vs. 23%, p = 0.01). The time from diagnostic biopsy may be a surrogate for disease activity, and a 2-year delay from biopsy might allow sufficient time to achieve disease remission. Overall, these data could aid family planning discussions and promote preconception disease optimization for patients and their providers.
Maternal Serum Metabolomics in Mid-Pregnancy Identifies Lipid Pathways as a Key Link to Offspring Obesity in Early Childhood
Creators: name: Perng, Wei
name: Pathmasiri, Wimal
name: Johnson, Randi K.
name: Rushing, Blake R.
name: Kechris, Katerina
name: Sumner, Susan J.
name: Francis, Ellen C.
name: Rawal, Shristi
name: Du, Xiuxia
name: Dabelea, Dana
name: Jansson, Thomas
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2024

description: Maternal metabolism during pregnancy shapes offspring health via in utero programming. In the Healthy Start study, we identified five subgroups of pregnant women based on conventional metabolic biomarkers: Reference (n = 360); High HDL-C (n = 289); Dyslipidemic–High TG (n = 149); Dyslipidemic–High FFA (n = 180); Insulin Resistant (IR)–Hyperglycemic (n = 87). These subgroups not only captured metabolic heterogeneity among pregnant participants but were also associated with offspring obesity in early childhood, even among women without obesity or diabetes. Here, we utilize metabolomics data to enrich characterization of the metabolic subgroups and identify key compounds driving between-group differences. We analyzed fasting blood samples from 1065 pregnant women at 18 gestational weeks using untargeted metabolomics. We used weighted gene correlation network analysis (WGCNA) to derive a global network based on the Reference subgroup and characterized distinct metabolite modules representative of the different metabolomic profiles. We used the mummichog algorithm for pathway enrichment and identified key compounds that differed across the subgroups. Eight metabolite modules representing pathways such as the carnitine–acylcarnitine translocase system, fatty acid biosynthesis and activation, and glycerophospholipid metabolism were identified. A module that included 189 compounds related to DHA peroxidation, oxidative stress, and sex hormone biosynthesis was elevated in the Insulin Resistant–Hyperglycemic vs. the Reference subgroup. This module was positively correlated with total cholesterol (R:0.10; p-value < 0.0001) and free fatty acids (R:0.07; p-value < 0.05). Oxidative stress and inflammatory pathways may underlie insulin resistance during pregnancy, even below clinical diabetes thresholds. These findings highlight potential therapeutic targets and strategies for pregnancy risk stratification and reveal mechanisms underlying the developmental origins of metabolic disease risk.
Microplastic pollution in urban streams across New Zealand: concentrations, composition and implications
Creators: name: Mora-Teddy, Aidan K.
name: Matthaei, Christoph D.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: Science Policy

description: Microplastic pollution in aquatic systems has been reported globally at an alarming rate, with an increasing number of documented negative biological consequences. Research on microplastic pollution in freshwaters has barely begun in New Zealand, and few studies from smaller lotic systems such as streams exist globally. We investigated the extent of microplastic pollution within urban streams across New Zealand and determined if microplastic concentrations were related to human population density and urbanisation of streams. Fifty-two streams were surveyed across five urban agglomerations in January 2019. Microplastics were found in samples from all sites at densities ranging from <1 to 44 items/m3. This concentration range was comparable to global data but lower than reported in another recent New Zealand study, probably due to differences in sampling methodology. Microplastic pollution was similar across all urban centres, and neither length of urbanised catchment nor urban proportion of the stream were significant predictors of microplastic concentrations. These findings suggest microplastic pollution in New Zealand streams are comparable to larger aquatic systems globally, and that smaller urban streams are significant transport pathways for microplastics. We also recommend standardising microplastic sampling methods to a greater extent in the future, to improve comparability across studies.
Measurement error and bias in real-world oncology endpoints when constructing external control arms
Creators: name: Meyer, Craig S.
name: Roose, James
name: Mahoney, Grace
name: Weberpals, Janick
name: Gan, Ryan W.
name: Stürmer, Til
name: Siddique, Juned
name: Zhang, Youyi
name: Hayden, Jennifer
name: Ailawadhi, Sikander
name: Batavia, Ashita S.
name: Ackerman, Benjamin
name: Giri, Smith
name: Wang, Jocelyn R.
name: Schneeweiss, Sebastian
name: Lund, Jennifer L.
name: Nadeem, Omar
name: Sarsour, Khaled
Publisher: name: Frontiers Media SA
Year: 2024

description: Introduction: While randomized controlled trials remain the reference standard for evaluating treatment efficacy, there is an increased interest in the use of external control arms (ECA), namely in oncology, using real-world data (RWD). Challenges related to measurement of real-world oncology endpoints, like progression-free survival (PFS), are one factor limiting the use and acceptance of ECAs as comparators to trial populations. Differences in how and when disease assessments occur in the real-world may introduce measurement error and limit the comparability of real-world PFS (rwPFS) to trial progression-free survival. While measurement error is a known challenge when conducting an externally-controlled trial with real-world data, there is limited literature describing key contributing factors, particularly in the context of multiple myeloma (MM). Methods: We distinguish between biases attributed to how endpoints are derived or ascertained (misclassification bias) and when outcomes are observed or assessed (surveillance bias). We further describe how misclassification of progression events (i.e., false positives, false negatives) and irregular assessment frequencies in multiple myeloma RWD can contribute to these biases, respectively. We conduct a simulation study to illustrate how these biases may behave, both individually and together. Results: We observe in simulation that certain types of measurement error may have more substantial impacts on comparability between mismeasured median PFS (mPFS) and true mPFS than others. For instance, when the observed progression events are misclassified as either false positives or false negatives, mismeasured mPFS may be biased towards earlier (mPFS bias = −6.4 months) or later times (mPFS bias = 13 months), respectively. However, when events are correctly classified but assessment frequencies are irregular, mismeasured mPFS is more similar to the true mPFS (mPFS bias = 0.67 months). Discussion: When misclassified progression events and irregular assessment times occur simultaneously, they may generate bias that is greater than the sum of their parts. Improved understanding of endpoint measurement error and how resulting biases manifest in RWD is important to the robust construction of ECAs in oncology and beyond. Simulations that quantify the impact of measurement error can help when planning for ECA studies and can contextualize results in the presence of endpoint measurement differences.
Measurement of changes to the menstrual cycle: A transdisciplinary systematic review evaluating measure quality and utility for clinical trials
Creators: name: Mickler, Alexandria K.
name: Hoppes, Emily
name: Mackenzie, Amelia C. L.
name: Cartwright, Alice F.
name: Chung, Stephanie
Publisher: name: Public Library of Science
Year: 2024

description: Despite the importance of menstruation and the menstrual cycle to health, human rights, and sociocultural and economic wellbeing, the study of menstrual health suffers from a lack of funding, and research remains fractured across many disciplines. We sought to systematically review validated approaches to measure four aspects of changes to the menstrual cycle—bleeding, blood, pain, and perceptions—caused by any source and used within any field. We then evaluated the measure quality and utility for clinical trials of the identified instruments. We searched MEDLINE, Embase, and four instrument databases and included peer-reviewed articles published between 2006 and 2023 that reported on the development or validation of instruments assessing menstrual changes using quantitative or mixed-methods methodology. From a total of 8,490 articles, 8,316 were excluded, yielding 174 articles reporting on 94 instruments. Almost half of articles were from the United States or United Kingdom and over half of instruments were only in English, Spanish, French, or Portuguese. Most instruments measured bleeding parameters, uterine pain, or perceptions, but few assessed characteristics of blood. Nearly 60% of instruments were developed for populations with menstrual or gynecologic disorders or symptoms. Most instruments had fair or good measure quality or clinical trial utility; however, most instruments lacked evidence on responsiveness, question sensitivity and/or transferability, and only three instruments had good scores of both quality and utility. Although we took a novel, transdisciplinary approach, our systematic review found important gaps in the literature and instrument landscape, pointing towards a need to examine the menstrual cycle in a more comprehensive, inclusive, and standardized way. Our findings can inform the development of new or modified instruments, which—if used across the many fields that study menstrual health and within clinical trials—can contribute to a more systemic and holistic understanding of menstruation and the menstrual cycle.
MERTK Inhibition as a Targeted Novel Cancer Therapy
Creators: name: Huelse, Justus M.
name: Holtzhausen, Alisha
name: Graham, Douglas K.
name: Thapa, Aashis
name: Earp, H. Shelton
name: Tanim, K. M.
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2024

description: In this issue honoring the contributions of Greg Lemke, the Earp and Graham lab teams discuss several threads in the discovery, action, signaling, and translational/clinical potential of MERTK, originally called c-mer, a member of the TYRO3, AXL, and MERTK (TAM) family of receptor tyrosine kinases. The 30-year history of the TAM RTK family began slowly as all three members were orphan RTKs without known ligands and/or functions when discovered by three distinct alternate molecular cloning strategies in the pre-genome sequencing era. The pace of understanding their physiologic and pathophysiologic roles has accelerated over the last decade. The activation of ligands bridging externalized phosphatidylserine (PtdSer) has placed these RTKs in a myriad of processes including neurodevelopment, cancer, and autoimmunity. The field is ripe for further advancement and this article hopefully sets the stage for further understanding and therapeutic intervention. Our review will focus on progress made through the collaborations of the Earp and Graham labs over the past 30 years.
Genetic structure and recent population expansion in the commercially harvested deep-sea decapod, Metanephrops challengeri (Crustacea: Decapoda)
Creators: name: Verry, Alexander J. F.
name: Walton, Kerry
name: Tuck, Ian D.
name: Ritchie, Peter A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Determining the genetic structure and population dynamics of harvested species are key aspects of effective fisheries management. New Zealand scampi (Metanephrops challengeri) is a species of nethropid lobster that supports a commercial fishery on the continental shelf and slope around New Zealand. To determine the genetic structure and historical population demography of New Zealand scampi, we sequenced a 623 base-pair fragment of the mitochondrial gene cytochrome c oxidase subunit one (CO1) from 321 individuals across six widely separated sites off the coast of mainland New Zealand and the subantarctic Auckland Islands, representing much of the species’ distribution. The Auckland Islands population was found to be genetically distinct from all other sampled populations, potentially resulting from an absence of continuous suitable habitat between the central-eastern South Island and the Auckland Islands. An isolation-by-distance pattern of genetic structure was also detected. With the exception of the Mercury Islands, all sampled populations showed signs of recent population expansion, potentially linked to changes in habitat availability during the glacial-interglacial cycles of the Pleistocene. We recommend that the current NZ scampi management areas and harvesting rates for each remain unchanged.
Metagenomic assessment of the bacterial breastfeeding microbiome in mature milk across lactation
Creators: name: Elison, Jed T.
name: Ingram, Kelly
name: Lin, Weili
name: Howell, Brittany R.
name: Tegge, Allison
name: Gregg, Collin
Publisher: name: Frontiers Media SA
Year: 2024

description: Introduction Research has illustrated the presence of a diverse range of microbiota in human milk. The composition of the milk microbiome varies across different stages of lactation, emphasizing the need to consider the lactation stage when studying its composition. Additionally, the transfer of both milk and skin microbiota during breastfeeding is crucial for understanding their collective impact on infant health and development. Further exploration of the complete breastfeeding microbiome is necessary to unravel the role these organisms play in infant development. We aim to longitudinally assess the bacterial breastfeeding microbiome across stages of lactation. This includes all the bacteria that infants are exposed to during breastfeeding, such as bacteria found within human milk and any bacteria found on the breast and nipple. Methods Forty-six human milk samples were collected from 15 women at 1, 4, 7, and 10 months postpartum. Metagenomic analysis of the bacterial microbiome for these samples was performed by CosmosID (Rockville, MD) via deep sequencing. Results Staphylococcus epidermidis and Propionibacteriaceae species are the most abundant bacterial species from these samples. Samples collected at 10 months showed higher abundances of Proteobacteria, Streptococcaceae, Lactobacillales, Streptococcus, and Neisseria mucosa compared to other timepoints. Alpha diversity varied greatly between participants but did not change significantly over time. Discussion As the bacterial breastfeeding microbiome continues to be studied, bacterial contributions could be used to predict and reduce health risks, optimize infant outcomes, and design effective management strategies, such as altering the maternal flora, to mitigate adverse health concerns.
The inflammatory response and tumorigenesis in the absence of the MAP3K8 gene
Creators: name: Trovato, Erika L.
Publisher: name: American University
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology

description: Skin cancer is the most common form of cancer in the United States, with more than one million cases diagnosed annually. Inflammation is believed to be a critical component to skin cancer progression, and therefore understanding genes that control inflammation is highly desirable. MAP3K8 (Tpl2) is a protein kinase in the MAPK signal transduction cascade. It has previously been shown that mice that lack MAP3K8 (Tpl2 -/- mice) have significantly higher tumor incidence and inflammation than wild-type (WT) controls. My thesis investigated the mechanism behind these effects by using inhibitors specific to the p38, JNK, PKC, and NF-kappaB pathways. Western blot analysis revealed differences in p38, JNK and NF-kappaB pathway activity between the WT and Tpl2 -/- mouse primary keratinocytes. In vivo experiments confirmed these differences and illustrated that the NF-kappaB pathway is the primary pathway responsible for the increased incidence of inflammation and tumorigenesis observed in Tpl2 -/- mice.
title: Манипуляции с дорогой в лечебной магической практике населения русско-белорусского пограничья по фольклорным данным
Creators: name: Колпакова, Юлия
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Рассматриваются практики использования дороги в народной лечебной магии. Анализируются заговоры и другие фольклорные сведения с территорий белорусского и украинского Полесья и сопредельных земель, территорий Псковской, Новгородской, Смоленской губерний и частично Русского Севера. В ходе исследования в ритуальной практике выделено использование дороги или перекрестка для «относа» болезни, для молитвы, для сбора необычных предметов для лечения и для «чудесного» нахождения магических текстов, для выкупа здоровья за угощение и для утилизации воды или песка, использованного в обряде очищения. Удалось установить, что манипуляции с дорогой в большом количестве случаев — это игра со словами и символами внутри текста заговора.
Brief an Johann I Bernoulli
Creators: name: Burnet, William
Publisher: name: [s.n.]
Year: 1712
Subjects: Burnet, Gilbert1643-1715
Gravesande, Willem Jacob1688-1742
Bernard, Jacques1658-1718
Bernoulli, Nicolaus1687-1759
Cheyne, George1671-1743
Craig, John1663-1731
Halley, Edmond1656-1742
Leibniz, Gottfried Wilhelm1646-1716
Meyer
Moivre, Abraham de1667-1754
Newton, Isaac1643-1727
Obdam, d'erster Kurator der Universität Leiden
Werenfels, Samuel1657-1740

description: Burnet hat vor 5 Tagen Joh. B.s Brief von 1712 03 05 erhalten. Er gibt Herrn Meyer aus Basel ein Päckchen mit dem Buch de Moivres mit. Er hat Moivre, Craig und Cheyne noch nicht persönlich getroffen. Cheyne hat die mathematischen Studien ganz aufgegeben und liest nur noch Autoren, die über mystische Theologie schreiben. Er kümmert sich nicht mehr um vergangene Angelegenheiten. Die zweite Auflage von Newtons Principia ist noch nicht erschienen. Man hat den Druck unterbrochen, um einige Retuschen anzubringen. Es wird einige ganz neue geometrische Konstruktionen in dieser Auflage geben. Halley hat Burnet vor einiger Zeit mitgeteilt, dass er Joh. B. die von ihm in Oxford herausgegebene Ausgabe der Conica des Apollonius schenken möchte. Nach all seinen Vorstellungen bei Obdam glaubt Burnet nicht mehr an einen Erfolg in der Leidener Berufungsangelegenheit. 'sGravesande hat ihm geschrieben, dass man einen Herrn Bernard, einen Verfasser von Ephemeriden, berufen will. Welch ein Abstieg Hollands. In Cambridge verspricht ein junger Mann namens Cotes viel. Burnet wird Joh. B. dessen allfällige Publikationen senden. Burnet hat sich ganz aus den Naturwissenschaften zurückgezogen. Er teilt hier ein Experiment mit, das man vor kurzem angestellt hat. Ein zwischen zwei geneigten Glasplatten angebrachter Öltropfen läuft immer zu der engsten Stelle zwischen den Platten, bis die Neigung der unteren Platte so gross ist, dass die natürliche Gravitation gegenüber der Attraktion durch die Glasplatten überwiegt. In der Royal Society ist man zur Zeit damit beschäftigt, mittels Originalbriefen zu beweisen, dass Newton seine Fluxionenmethode mehr als sieben Jahre vor Leibniz gekannt hat und dass Leibniz bei seinem Aufenthalt in London Gelegenheit hat, diese bei Collins kennenzulernen. Weiter sollen Briefe von Leibniz, in denen er um Aufklärung bat, beweisen, dass dieser die Methode Newtons noch fünf Jahre nach ihrer Entdeckung nicht begriffen hatte.
description: Diese Kontroverse wurde durch die Rezension von Newtons Schriften De quadratura curvarum und Enumeratio linearum tertii ordinis [beide publiziert als Anhang zu Newton, Opticks, 1704] in den AE [Januarii 1705, p.30-36] hervorgerufen. Grüsse an Joh. B.s Frau und Nic. I B. P.S. Grüsse auch an Werenfels. Der Überbringer des Briefes bringt ein Porträt von Burnets Vater [Gilbert] für Werenfels mit.
description: von William Burnet
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Kopie des Briefes unter L Ia 908:Bl.184-185
Missing in action: The UN Water Action Agenda needs an overhauled commitment-setting process
Creators: name: Nyarko, Kwabena
name: Momanyi, Eric
name: Cronk, Ryan
name: Mcbroom-Fitterer, Cameron
name: Lantagne, Daniele
name: Brocklehurst, Clarissa
name: Rodriguez, Laura Gomez
name: Scharp, Cecilia
name: Evans, Barbara
Publisher: name: Public Library of Science
Year: 2024

description: In March 2023, the United Nations (UN) held the first water conference since 1977. The UN 2023 Water Conference brought together more than 3000 representatives from UN Member States, intergovernmental organizations, UN entities, civil society (including international and national non-governmental organizations), and academia. The conference aimed to “unite the world for water” around the building blocks of “commitment to action, sustained and scalable implementation, and follow-up and review processes”. This conference was timely, given the inextricable link between water and the fortunes of nations and the impacts of climate change, conflict, and pandemics. UN Member States and other stakeholders were invited to make voluntary commitments to catalyze action. These commitments would form the Water Action Agenda (WAA), designed to accelerate progress in the Water Action Decade (2018–2028) and the Sustainable Development Goal (SDG) period (2015–2030)
Brief an William Burnet
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1712
Subjects: Burnet, Gilbert1643-1715
Barrow, Isaac1630-1677
Bernard, Jacques1658-1718
Bernoulli, Jakob1655-1705
Bernoulli, Nicolaus1687-1759
Boulliau, Ismael1605-1694
Cheyne, George1671-1743
Collins, John1625-1683
Fermat, Pierre de1601-1665
Halley, Edmond1656-1742
Hermann, Jacob1678-1733
Leibniz, Gottfried Wilhelm1646-1716
Moivre, Abraham de1667-1754
Newton, Isaac1643-1727
Roberval, Gilles Personne de1602-1675
Werenfels, Samuel1657-1740

description: Joh. B. fragt, ob die Royal Society nichts Besseres zu tun hat, als die Priorität Newtons gegenüber Leibniz darzutun. Beide haben ihre Verdienste. Und selbst wenn Leibniz in London bei Collins etwas von Newton gelesen hat, heisst das noch nicht, dass er nichts selbst erfunden hat. Man könnte sonst auch so gegenüber Jacob und Johann Bernoulli argumentieren, die Leibnizens erste Publikation selbständig studiert und dann sofort so grosse eigene Fortschritte gemacht haben, dass Leibniz den Differentialkalkül sowohl als den seinen wie den ihren bezeichnet hat. Folgt man der englischen Argumentation, gäbe es nach Newton keine eigenen neuen Entdeckungen mehr. So hat tatsächlich auch Cheyne argumentiert, womit er allerdings auch Newton trifft, vor welchem z.B. Barrow, Fermat, Bulliaud und Roberval über Indivisiblen und Fluxionen geschrieben haben, die ihrerseits wieder von Archimedes profitierten, bei dem man die ersten Spuren des unendlich Kleinen oder der Indivisiblen oder der Fluxionen findet. Man soll jedem sein Recht lassen, und die Royal Society soll sich nützlicheren Dingen zuwenden. Joh. B. legt einen Brief zur Weiterleitung an Nic. I B. bei. Werenfels wird sich für das übersandte Porträt bei Burnets Vater bedanken. Frau und Kinder Joh. B.s lassen grüssen.
description: von Johann I Bernoulli
description: Datum am Briefend eigenhändig
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Weitere Abschrift unter L Ia 908:Bl.208-209
Medical data mining issues and experiments
Creators: name: Veen, Ranjit S.
Publisher: name: American University
Year: 2023
Subjects: classificationCode: 46
subject: Information and computing sciences
classificationCode: 4602
subject: Artificial intelligence

description: Data analysis and data mining methods have been extensively applied for industrial and business applications; however, their utilization in medicine and healthcare is sparse. The data mining techniques such as Neural Network, Naive Bayes, and Association rules are at present not well explored on medical databases. The application of data mining techniques on medical databases is certainly a challenging process considering the high volume, complexity, and poor quality of the medical databases. In this thesis, we discuss the challenges facing the medical data mining. The focus is on the issues, difficulties and the discovered rules. Using commercially available data mining tools namely XLMiner, Knowledge Studio, different data mining techniques such as Neural Network, Naive Bayes, and Association rules, Classification Trees are applied on Thrombosis medical database. While some results confirm with experts, some are trivial and redundant rules.
Brief an Johann I Bernoulli
Creators: name: Burnet, William
Publisher: name: [s.n.]
Year: 1712
Subjects: Bernoulli, Nicolaus1687-1759
Craig, John1663-1731
Leibniz, Gottfried Wilhelm1646-1716
Newton, Isaac1643-1727

description: Burnet und Craig sind Nic. I B. für die Mitteilung so vieler Entdeckungen sehr dankbar. Sie bedauern, ihn nicht wenigstens über den Winter in England halten zu können. Nic. I B. wird Joh. B. über die Experimente, mit denen dieser nicht zufrieden ist, sowie über den Disput zwischen Newton und Leibniz berichten.
description: von William Burnet
description: 1 Seite leer
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Abschrift unter L Ia 908:Bl.186
Medical data mining issues and experiments
Creators: name: Veen, Ranjit S.
Publisher: name: American University
Year: 2023

description: Data analysis and data mining methods have been extensively applied for industrial and business applications; however, their utilization in medicine and healthcare is sparse. The data mining techniques such as Neural Network, Naive Bayes, and Association rules are at present not well explored on medical databases. The application of data mining techniques on medical databases is certainly a challenging process considering the high volume, complexity, and poor quality of the medical databases. In this thesis, we discuss the challenges facing the medical data mining. The focus is on the issues, difficulties and the discovered rules. Using commercially available data mining tools namely XLMiner, Knowledge Studio, different data mining techniques such as Neural Network, Naive Bayes, and Association rules, Classification Trees are applied on Thrombosis medical database. While some results confirm with experts, some are trivial and redundant rules.
Brief an William Burnet
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1712
Subjects: Bernoulli, Nicolaus1687-1759
Craig, John1663-1731
Halley, Edmond1656-1742
Holländer, Tobias1636-1711
Meyer
Moivre, Abraham de1667-1754
Newton, Isaac1643-1727

description: Joh. B. dankt Burnet für den freundlichen Empfang seines Neffen Nic. I B. in England. Dieser hat ihm das von Burnet erbetene Buch Amaltheum Astronomicum des Schaffhauser Bürgermeisters Holländer gesandt. Er wird es dem Amsterdamer Buchhändler Wettstein mitgeben zusammen mit einer Abhandlung über ein neues musikalisches System, welches Burnet wegen des Systems von Shuttleworths erbeten hat. Nic. I B. hat mitgeteilt, dass Craig dem Basler Meier einen Brief für Joh. B. mitgegeben hat, der aber bis jetzt nicht angekommen ist. Da Nic. I B. nach seiner Abreise aus England und Frankreich jetzt in Holland weilt, hat Joh. B. auch den mitgegebenen Brief Burnets an ihn noch nicht erhalten. Nach Nic. I B.s Informationen soll die zweite Auflage von Newtons Principia sehr bald erscheinen. Newton hat einige Korrekturen angebracht, die ihm Nic. I B. im Auftrag von Joh. B. mitgeteilt hat. Joh. B. ist deshalb auf die neue Ausgabe gespannt, zumal er die Publikation einiger weiterer Anmerkungen zur ersten Auflage in den AE vorbereitet hat. Diese sollen möglichst zur gleichen Zeit erscheinen, damit der Leser beide Auflagen vergleichen kann. Joh. B. wäre glücklich, seinen Namen neben den neuen Beiträgen eines so grossen Mannes anzutreffen, vorausgesetzt, die neue Auflage enthält Gemeinsamkeiten mit seinem Aufsatz. Newton, Halley und de Moivre waren sehr nett zu Nic. I B., der sie sehr lobt. Joh. B. hat sich vor einigen Wochen bei Halley und de Moivre bedankt und bittet Burnet, dies für ihn auch bei Newton zu tun. Desgleichen bedankt sich Joh. B. bei Burnet, dessen Vater er grüsst.
description: von Johann I Bernoulli
description: Datum am Briefkopf eigenhändig
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Digitalisierung=Digitization=Numérisation TIFF 05.04.2015
description: Weitere Abschrift unter L Ia 908:Bl.210
Nutrient attenuation in a shallow, gravel-bed river. I. In-situ chamber experiments
Creators: name: Quinn, John M.
name: J. Christopher Rutherford
name: Schiff, Sherry J.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Dissolved nutrient uptake and metabolism by periphyton in a central North Island gravel-bed river were investigated using recirculating in-situ chambers. Dissolved inorganic nitrogen (DIN) uptake was correlated with photosynthesis and chlorophyll but N uptake and carbon fixation were partly de-coupled indicating storage. Dissolved reactive phosphorus (DRP) uptake was only weakly correlated with photosynthesis. Diatoms and green algae relied on DRP in the water, but Cyanobacteria met part of their P needs from storage. Dissolved organic nutrients were excreted in both light and dark incubations, with approximately 50% of DIN uptake during photosynthesis excreted as DON. To simulate diurnal variations in nutrients, oxygen and pH existing computer models need to de-couple photosynthesis from nutrient uptake, allow for variable stoichiometry and better quantify recycling of organic nutrients.
Additional file 4 of scDART: integrating unmatched scRNA-seq and scATAC-seq data and learning cross-modality relationship simultaneously
Creators: name: Zhang, Ziqi
name: Yang, Chengkai
name: Zhang, Xiuwei
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 4 Review history.
title: Behinderung und Gerechtigkeit
Creators: name: Kumptner, Karoline
Year: 2014

description: Diese Dissertation setzt sich mit dem Umgang mit Menschen mit Behinderungen sowohl aus pränataler Sicht sowie mit deren Umgang in der Gesellschaft, insb der Arbeitswelt, auseinander. Das erste Kapitel zeigt einen Überblick verschiedener Definitionen des Begriffes der Behinderung in den Bereichen der Medizin, der Sonder- und Heilpädagogik und der Rechtswissenschaften. Das zweite Kapitel schildert drei sehr unterschiedliche Gerechtigkeitstheorien – den Utilitarismus aus der Sicht von Singer, die „Gerechtigkeit als Fairneß“ von Rawls und den Fähigkeitenansatz von Nussbaum – und untersucht die Frage, ob diese Theorien auch auf Menschen mit Behinderungen anwendbar sind. Das dritte Kapitel beschäftigt sich mit dem Umgang mit Menschen mit Behinderungen aus pränataler Sicht. Im Zuge dessen werden verschiedene Methoden der Pränataldiagnostik sowie neue pränataldiagnostische Testverfahren erläutert und anschließend wird auf die Frage eingegangen, ob es durch diese zu einer Diskriminierung von behinderten Menschen kommen kann. Darüber hinaus wird auf einige Fälle der „wrongful-birth“- Problematik eingegangen. Das letzte Kapitel behandelt den Umgang mit Menschen mit Behinderungen in der Gesellschaft. Der Schwerpunkt liegt dabei auf der Integration behinderter Menschen in die Arbeitswelt, weshalb besonders auf einige Normen des Behinderteneinstellungsgesetzes als auch einige OGH- sowie EuGH- Fälle eingegangen wird.
description: This thesis is about the interaction of people with disabilities, from the prenatal point of view and with their interaction in society, especially in their working environment. The first chapter gives an overview of different definitions of the term “disability” from the medical, special and remedial education and the legal point of view. The second chapter describes three different theories of justice – the utilitarianism including the view of Singer, Rawls’ „A theory of justice“ and the “Fähigkeitenansatz” by Nussbaum - and analyzes the question whether these theories are also applicable to people with disabilities or not. The third chapter deals with the interaction of people with disabilities from prenatal perspective and explains various methods of prenatal diagnosis and new prenatal test methods. It also examines the question, if disabled people get discriminated because of prenatal diagnosis. Furthermore, it contains cases of "wrongful-birth" judicature. The last chapter is about disabled people in our society. The focus lies on the integration of disabled people into the working environment, therefore some cases by the European Court of Justice and the OGH are described.
Stichopathes occidentalis
Creators: name: Lima, Manuela M.
name: Cordeiro, Ralf T. S.
name: Perez, Carlos D.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Antipatharia
Antipathidae
Stichopathes
Stichopathes occidentalis

description: Stichopathes occidentalis (Gray, 1860)
Fig. 35
Cirrhipathes setacea var. occidentalis Gray, 1860: 311.
Stichopathes occidentalis: Brook, 1889: 92–93, figs. 7,8; Opresko & Sanchez, 2005: 500–501, figs. 9,10; Opresko, 2009: 362; Cordeiro et al., 2012: 826–828, figs 1,2; Opresko, 2014: 1–2, fig 1a.
Type and type locality. BMNH, Turks Island (Gray, 1860), depth unknown.
Diagnosis. “Gray’s type of this form is 2.74 m long, very slender and tapering; the base is 2 mm in diameter, and the apex 0.2 mm. The whole stem is like a slender whip lash, and shows no signs of spiral curvature. The spines are short and conical, but somewhat compressed. In more slender portions of the specimen they are arranged in dextrorse spirals which are about twice the length of a spine apart. Nearer the base the spiral arrangement is lost, and the spines are thicker and stand out horizontally” (Brook, 1889).
Distribution. Turks Island (Gray, 1860), off West Africa, Islas das Rolas (Broch, 1920 apud Opresko, 2014), Caribbean Sea (Opresko & Sanchez, 2005; Opresko, 2009), off Pernambuco, Brazil (Cordeiro et al., 2012); and Ascension Island (fig. 35) (Opresko, 2014); from 30 m (Opresko, 2014) to 70 m depths (Opresko, 2009).
description: Published as part of Lima, Manuela M., Cordeiro, Ralf T. S. & Perez, Carlos D., 2019, Black Corals (Anthozoa: Antipatharia) from the Southwestern Atlantic, pp. 1-67 in Zootaxa 4692 (1) on page 12, DOI: 10.11646/zootaxa.4692.1.1, http://zenodo.org/record/3528942