cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of In vitro antiplasmodial activity and toxicological profile of extracts, fractions and chemical constituents of leaves and stem bark from Dacryodes edulis (Burseraceae)
Creators: name: Dongmo, Kevine Johane Jumeta
name: Tali, Mariscal Brice Tchatat
name: Fongang, Yannick Stéphane Fotsing
name: Taguimjeu, Pierre Leonel K. Tafokeu
name: Kagho, Donald Ulrich Kenou
name: Bitchagno, Gabin Thierry
name: Lenta, Bruno Ndjakou
name: Boyom, Fabrice Fekam
name: Sewald, Norbert
name: Ngouela, Silvère Augustin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. HR-ESI mass spectrum of 1. Figure S2. 1H NMR spectrum(Pyridin-d5, 600 MHz) of 1. Figure S3. 13C NMR spectrum (Pyridin-d5, 150 MHz) of 1. Figure S4. ESI mass spectrum of2. Figure S5. 1H NMR spectrum (CDCl3, 600 MHz) of 2. Figure S6. 13C NMR spectrum (CDCl3, 150 MHz) of 2. Figure S7. 1H NMR spectrum(Pyridin-d5, 600 MHz) of 3. Figure S8. 1H NMR spectrum(Pyridin-d5, 600 MHz) of 4. Figure S9. 13C NMR spectrum(Pyridin-d5, 150 MHz) of 4. Figure S10. HR-ESI mass spectrum of 5. Figure S11. 1H NMRspectrum (CD3OD, 600 MHz) of 5. Figure S12. 13C NMRspectrum (CD3OD, 150 MHz) of 5. Figure S13. 1H NMRspectrum (CD3OD, 600 MHz) of 6. Figure S14. 13C NMRspectrum (CD3OD, 150 MHz) of 6. Figure S15. HR-ESI mass spectrum of 7. Figure S16. 1H NMRspectrum (CDCl3, 600 MHz) of 7. Figure S17. 13C NMRspectrum (CDCl3, 150 MHz) of 7. Figure S18. 1H NMRspectrum (CDCl3, 600 MHz) of 8. Figure S19. 13C NMRspectrum (CDCl3, 150 MHz) of 8. Figure S20. HR-ESI mass spectrum of 9. Figure S21. 1H NMRspectrum (CDCl3, 600 MHz) of 9. Figure S22. 13C NMRspectrum (CDCl3, 150 MHz) of 9. Figure S23. 1H NMRspectrum (CD3OD, 600 MHz) of 10. Figure S24. 1H NMRspectrum (CDCl3, 600 MHz) of 11. Figure S25. 13C NMRspectrum (CDCl3, 150 MHz) of 11. Figure S26. 1H NMRspectrum (CDCl3, 600 MHz) of 12. Figure S27. 13C NMRspectrum (CDCl3, 150 MHz) of 12. Figure S28. 1H NMRspectrum (CDCl3, 600 MHz) of 13. Figure S29. 13C NMRspectrum (CDCl3, 150 MHz) of 13. Figure S30. 1H NMRspectrum (CDCl3, 600 MHz) of 14. Figure S31. 13C NMRspectrum (CDCl3, 150 MHz) of 14.
Hilaria, Claudius, Iason and Maurus, wife, husband and two sons, martyrs of Rome, buried on the via Salaria
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2015
Subjects: History

description: All evidence related to Hilaria, Claudius, Iason and Maurus, wife, husband and two sons, martyrs of Rome, buried on the via Salaria.
Mitochondrial remodeling supports migration in White-crowned Sparrows (Zonotrichia leucophrys)
Creators: name: C. Mesquita, Paulo H.
name: Rhodes, Emma
name: Yap, Kang
name: Mueller, Breanna
name: Hill, Geoffrey
name: Hood, Wendy
name: Kavazis, Andreas
Publisher: name: Zenodo
Year: 2024
Subjects: bird migration
Mitochondrial dynamics
mitochondrial physiology
skeletal muscle
Mitochondrial Fusion

description: The migratory movements undertaken by birds are among the most energetically demanding behaviors observed in nature. Mitochondria are the source of aerobic energy production on which migration depends, but a key component of mitochondrial function, mitochondrial remodeling, has not been investigated in the context of bird migration. We measured markers of mitochondrial remodeling in the skeletal muscles of the Gambel's (migratory) and Nuttall's (non-migratory) White-crowned Sparrows within and outside migratory periods. Gambel's were collected in 1) a non-migration period (baseline), 2) preparation to depart for spring migration (pre-migration), and 3) active autumn migration (mid-migration). Nuttall's were collected at time points corresponding to baseline and mid-migration in Gambel's. Across all sampling periods, we found that migratory birds had greater mitochondrial remodeling compared to non-migratory birds. Furthermore, birds from the migratory population also displayed flexibility, increasing several markers of mitochondrial remodeling (e.g., NRF1, OPA1, Drp1) pre- and during migration. Further, the greater levels of mitochondrial remodeling and its upregulation during migration were specific to the pectoralis muscle used in flapping flight. Our study is the first to show that mitochondrial remodeling supports migration in Gambel's White-crowned Sparrows, indicating a highly specific and efficient phenotype supporting the increased energetic demands of migration.
description: Funding provided by: Auburn UniversityROR ID: https://ror.org/02v80fc35Award Number:
Funding provided by: National Science FoundationROR ID: https://ror.org/021nxhr62Award Number: OIA1736150
Funding provided by: National Science FoundationROR ID: https://ror.org/021nxhr62Award Number: IOS2223528
Funding provided by: National Science FoundationROR ID: https://ror.org/021nxhr62Award Number: IOS2037741
title: Münsteraner Fragebogen zur Evaluation – Zusatzmodul digitale Lehre (MFE-ZdL)
Creators: name: Oberhoff, L.
name: Mühlinghaus, R.
name: Kegel, K.
name: Humberg, S.
Publisher: name: ZIS - GESIS Leibniz Institute for the Social Sciences
Year: 2022
Subjects: subject: Lehrevaluation
subject: digitale Lehre
subject: Online-Vorlesung

description: Die hier dokumentierte Itembatterie kann im Rahmen von studentischer Veranstaltungskritik eingesetzt werden. Sie dient dazu, die Einschätzungen von Studierenden bezüglich verschiedener Aspekte von digitaler Lehre zu erfassen. Am Institut für Psychologie der Westfälischen Wilhelms-Universität Münster wurde der Fragebogen bzw. Vorversionen davon im Sommersemester 2020, Wintersemester 2020/21 und im Sommersemester 2021 zusätzlich zum Kernfragebogen „Münsteraner Fragebogen zur Evaluation von Seminaren (MFE-Sr)“ bzw. „Münsteraner Fragebogen zur Evaluation von Vorlesungen (MFE-Vr)“ eingesetzt, um studentische Rückmeldungen zu den wegen der COVID-19 Pandemie eingeführten digitalen Lehrelementen zu erhalten. Der Fragebogen eignet sich insbesondere zur Evaluation rein digitaler Veranstaltungen, in reduzierter Form (mit entsprechender Itemauswahl) auch zur Evaluation von Veranstaltungen im Hybridformat oder Präsenzveranstaltungen mit ergänzenden digitalen Materialien.
description: Zusammenstellung sozialwissenschaftlicher Items und Skalen (ZIS)
Interview With Dr. Julie Sykes
Creators: name: SLS Working Papers
name: Lavolette, Elizabeth
name: Lavolette, Elizabeth
name: Sterling, Scott
Publisher: name: SLS Working Papers
Year: 2012
Subjects: subject: Second language acquisition
subject: Applied linguistics

description: Dr. Julie Sykes is Assistant Professor of Spanish and Hispanic Linguistics at the University of New Mexico. She delivered a keynote address at the Second Language Studies Symposium titled Digital gamemediated language learning: From ideas to implementation. This interview took place on 2/24/2012. Her website can be found at http://www.unm.edu/~spanport/faculty/sykes/.
Interview With Dr. Julie Sykes
Creators: name: SLS Working Papers
name: SLS Working Papers
name: Lavolette, Elizabeth
name: Lavolette, Elizabeth
Publisher: name: Humanities Commons
Year: 2012
Subjects: subject: Applied linguistics
subject: Second language acquisition

description: Dr. Julie Sykes is Assistant Professor of Spanish and Hispanic Linguistics at the University of New Mexico. She delivered a keynote address at the Second Language Studies Symposium titled Digital gamemediated language learning: From ideas to implementation. This interview took place on 2/24/2012. Her website can be found at http://www.unm.edu/~spanport/faculty/sykes/.
Barriers to the performance of timely hemodialysis when recommended by one United States poison center: a retrospective review
Creators: name: Gnirke, Marlis
name: Davies, Emily
name: Hoffman, Robert S.
name: Su, Mark K.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Hemodialysis has an essential role in the treatment of certain poisoned patients, both by enhancing the elimination of select poisons and correcting underlying fluid, electrolyte, and acid-base disturbances. We sought to identify barriers to the performance of hemodialysis when it was recommended by our poison center. Data from a single United States poison center were retrospectively queried for adult patients for whom the poison center recommended intermittent hemodialysis for poison removal. The primary outcome was the performance of intermittent hemodialysis within 12 h of the poison center recommendation, which we defined as timely hemodialysis. Univariable and multivariable logistic regressions were performed to assess the effect of the following variables on this outcome: age group, patient sex, time of day of the recommendation, day of week of the recommendation, year of the recommendation, hospital location, and poison category. A total of 535 patient encounters were analyzed. The majority (73.5%) of patients had intermittent hemodialysis performed within 12 h of when it was recommended. The multivariable analyses showed that the odds of receiving recommended intermittent hemodialysis within 12 h were significantly lower when the recommendation was made during the nighttime (OR: 0.660; 95% CI: 0.442–0.987) compared to daytime and during the weekend (OR: 0.605; 95% CI: 0.398–0.918) compared to weekdays. Intermittent hemodialysis is resource-intensive and requires specialized equipment and personnel, which is likely less available outside of regular business hours. This study is limited by its retrospective nature and may not be generalizable to other poison centers. Patients for whom our poison center recommended intermittent hemodialysis during non-weekday times had lower odds of receiving timely hemodialysis. Hospital administrators and healthcare providers should be aware of this potential treatment obstacle for poisoned patients and identify the specific barriers involved in order to facilitate timely hemodialysis.
Effects of Rehearsal on ESL Learners’ Responses to Test Tasks
Creators: name: SLS Working Papers
name: SLS Working Papers
name: Lavolette, Elizabeth
name: Lavolette, Elizabeth
Publisher: name: Humanities Commons
Year: 2013
Subjects: subject: Applied linguistics
subject: Second language acquisition

description: Second language (L2) testing is often stressful for test takers, especially when they take high-stakes tests such as the TOEFL. On the iBT TOEFL independent speaking questions, for example, test takers are given 15 seconds to prepare to respond to a prompt (Educational Testing Service, 2008) and have only one chance to record their answer, which puts test takers under great pressure. However, the necessity of this stressful situation has not been empirically validated; that is, the effects of giving learners planning opportunities are unclear.
Effects of Rehearsal on ESL Learners' Responses to Test Tasks
Creators: name: SLS Working Papers
name: Jung, Sehoon
name: Lavolette, Elizabeth
name: Smith, Megan
Publisher: name: SLS Working Papers
Year: 2013
Subjects: subject: Second language acquisition
subject: Applied linguistics

description: Second language (L2) testing is often stressful for test takers, especially when they take high-stakes tests such as the TOEFL. On the iBT TOEFL independent speaking questions, for example, test takers are given 15 seconds to prepare to respond to a prompt (Educational Testing Service, 2008) and have only one chance to record their answer, which puts test takers under great pressure. However, the necessity of this stressful situation has not been empirically validated; that is, the effects of giving learners planning opportunities are unclear.
Life Is Quantum Biology Effects Explained from the Schrodinger Equation, Serious or Life-threatening Conditions or Diseases, and COVID-19 Results
Creators: name: Tieu, Huu
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420899
subject: Traditional, complementary and integrative medicine not elsewhere classified
classificationCode: 310103
subject: Cell metabolism
classificationCode: 310106
subject: Enzymes
classificationCode: 310105
subject: Cellular interactions (incl. adhesion, matrix, cell wall)
classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310114
subject: Systems biology

description: Background: A plant based approach was undertaken to ascertain the efficacy of the Innovation of a new medical Technology based on similar activity to the circulatory system pf plants. Basic Technology formulations were introduced into plant structures to evaluate the responses for cell division and plant growth which ultimately lead to the final product. This Innovation transforms and enhances common botanical/herb products such that they can be used to treat COVID-19 infection and Serious or Life-threatening conditions or diseases. They can restore the diseased cell's abnormal metabolism to homeostasis and return it to normal function by slowing or reversing the cell's malfunctioning metabolism, or in other words, slowing or reversing the disease process.
Unveiling the Secrets of Ultra-Smooth Edges of Two-Dimensional Materials
Creators: name: Shi, Pengjie
name: Xu, Zhiping
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 401707
subject: Solid mechanics

description: The roughness of mechanically cleaved edges in 2D crystals and glasses is analyzed based on molecular dynamics simulations using chemically-accurate machine-learning force fields.It is found that ultra-flat armchair and zigzag edges can be cleaved from graphene by aligning the loading direction with specific lattice orientations.This correlation becomes blurred in three-atom-thick 2D silica crystals and is disrupted by topological disorder in 2D silica glasses.Fracture mechanics analysis elucidates the kinetic and dynamic factors responsible for crack deflection and edge roughening.These insights provide guidance for achieving minimum edge roughness in 2D materials, which is crucial for their applications in mechanical and electronic devices.
Loperamide-induced severe cardiotoxicity: a toxicokinetic and toxicodynamic analysis derived from a case series and the published literature
Creators: name: Ionmhain, Úna Nic
name: Chiew, Angela L.
name: Tierney, Michael
name: Al Ahmad, Judy
name: Pidcock, Stefanie
name: Whan, Faye Titania
name: Mackenzie, Lorraine
name: Roberts, Michael S.
name: Roberts, Darren M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Medicine
Pharmacology
Cancer
Virology

description: Chronic loperamide overdose is associated with cardiotoxicity. We describe the toxicokinetics of loperamide and N-desmethyl loperamide, and their concentration–response relationship on cardiotoxicity in newly described and published cases. We obtained serial loperamide and N-desmethyl loperamide concentrations, and corresponding electrocardiographic intervals in three episodes (two patients) of loperamide-related cardiotoxicity. A toxicokinetic and toxicodynamic analysis was undertaken that included data from previous publications to explore the relationship between these variables. Patients presented with dizziness, bradycardia, loss of consciousness, and jerking or ventricular tachycardia after taking loperamide 320–400 mg/day for weeks or years. In one patient, ventricular tachycardia occurred on days two and three post-admission. Prolonged electrocardiographic intervals resolved after approximately five days. Admission loperamide concentrations were 5.37–288 μg/L and the terminal elimination half-lives were 21.3–38.7 h. Admission N-desmethyl loperamide concentrations were 87.67–256.34 μg/L and the terminal elimination half-life was 31.9–88.9 h. Overall, there were 42 loperamide and 35 N-desmethyl loperamide concentrations with paired electrocardiographic data, and the concentration–response relationship was derived using a maximum effect (Emax) model. Lower loperamide concentrations were associated with electrocardiographic abnormalities, compared to N-desmethyl loperamide concentrations. The total relative loperamide concentration, which combines both concentrations into a single value using in vitro inhibitory potencies at cardiac ion channels, out-performed either parent or metabolite concentrations alone for predicting cardiotoxicity on receiver operating characteristic curves. Loperamide and N-desmethyl loperamide have long elimination half-lives causing prolonged cardiotoxicity. Higher loperamide and N-desmethyl loperamide concentrations are associated with prolonged electrocardiographic intervals. Patients with chronic loperamide overdose are at risk of cardiotoxicity that persists for days due to persistent loperamide and N-desmethyl loperamide concentrations. We believe patients with loperamide overdose need an admission electrocardiograph and continuous monitoring until electrocardiographic changes resolve.
Anregung zur Aufmerksamkeit
Creators: name: Kranen, Annette
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft
Year: 2024

description: Rez. von: Karl Kusserow (Hg.), Picture Ecology. Art and Ecocriticism in Planetary Perspective. Princeton/Oxford, Princeton University Press 2021
description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Jg. 77 Nr. 11 (2024): Kunstchronik. Monatsschrift für Kunstwissenschaft
Gamma-hydroxybutyrate poisoning: clinical diagnosis versus laboratory findings
Creators: name: Skjelland, Didrik
name: Jørgenrud, Benedicte M.
name: Gundersen, Karsten
name: Bjørnaas, Mari Asphjell
name: Brekke, Mette
name: Dalaker, Vivian M.
name: Furuhaugen, Håvard
name: Vallersnes, Odd Martin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Neuroscience
Biotechnology
Cancer
Mental Health
Hematology
Virology

description: Patients poisoned with gamma-hydroxybutyrate may need urgent medical treatment. The clinical manifestations are heterogeneous, and the level of consciousness is often unstable, with fluctuations between agitation and coma. We aimed to investigate the accuracy of the clinical diagnosis of gamma-hydroxybutyrate poisoning compared to laboratory findings in blood samples. We did a prospective observational study, including patients ≥16 years of age admitted to hospital with a clinical diagnosis of gamma-hydroxybutyrate poisoning. The diagnosis was established by the doctor treating the patient based on the clinical information and/or information from the patient and/or the patient’s companions. Blood samples were taken at admission and analyzed using ultra high-performance liquid chromatography–tandem mass spectrometry. There were 87 patients with a median age of 35 years (IQR: 30–42 years), and 58.6% (51/87) were male. Gamma-hydroxybutyrate was found in blood samples taken from 60 (69.0%) patients. The median Glasgow Coma Scale of all patients on arrival at hospital was 6 (IQR: 3–10), and 53.3% of the patients who tested positive for gamma-hydroxybutyrate presented with a Glasgow Coma Scale of 3. The Glasgow Coma Scale was significantly lower (P <0.001) among patients who tested positive for gamma-hydroxybutyrate, and was inversely correlated with gamma-hydroxybutyrate concentrations. Among the 60 patients testing positive for gamma-hydroxybutyrate, 28 (46.7%) needed treatment in an intensive care unit, and three (5.0%) required endotracheal intubation. In 58 (96.7%) of the 60 patients who tested positive for gamma-hydroxybutyrate, other drugs were also found, most frequently amfetamines, cocaine, and benzodiazepines. The frequent co-consumption of other psychoactive drugs makes the clinical diagnosis of gamma-hydroxybutyrate challenging, and poisoning with other central nervous system depressants was frequently observed among those patients testing negative for the gamma-hydroxybutyrate. In only two out of three patients with clinically suspected gamma-hydroxybutyrate poisoning was gamma-hydroxybutyrate found in a blood sample, indicating that clinicians might overdiagnose gamma-hydroxybutyrate poisoning.
A pregnant woman with diquat poisoning leading to miscarriage and pontine haematoma
Creators: name: Shang, Rui-kai
name: Tian, Qiao-xin
name: Jian, Xiang-dong
name: Liu, Hong-yu
name: Liu, Yu-ru
name: Li, Qi-lu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A pregnant woman with diquat poisoning leading to miscarriage and pontine haematoma
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 22/2024
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2024
Subjects: subject: 080

description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Grundschulen zur Prüfungsordnung für die Lehramtsbachelorstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Grundschulen zur Prüfungsordnung für die Lehramtsbachelorstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Haupt-, Real-, Sekundar- und Gesamtschulen zur Prüfungsordnung für die Lehramtsbachelorstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Haupt-, Real-, Sekundar- und Gesamtschulen zur Prüfungsordnung für die Lehramtsmasterstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Gymnasien und Gesamtschulen zur Prüfungsordnung für die Lehramtsbachelorstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Gymnasien und Gesamtschulen zur Prüfungsordnung für die Lehramtsmasterstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Berufskollegs zur Prüfungsordnung für die Lehramtsbachelorstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt an Berufskollegs zur Prüfungsordnung für die Lehramtsmasterstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt für sonderpädagogische Förderung zur Prüfungsordnung für die Lehramtsbachelorstudiengänge
description: Fächerspezifische Bestimmungen an der Technischen Universität Dortmund für das Unterrichtsfach Englisch für ein Lehramt für sonderpädagogische Förderung zur Prüfungsordnung für die Lehramtsmasterstudiengänge
description: Berichtigung der Fächerspezifische Bestimmungen für das Unterrichtsfach Kunst (1-Fach) zur Prüfungsordnung für die Lehramtsbachelorstudiengänge für ein Lehramt an Gymnasien und Gesamtschulen an der Technischen Universität Dortmund vom 30. Januar 2024 (AM 3/2024, S. 33 ff.)
description: Amtliche Mitteilungen der Technischen Universität Dortmund;2024; 22
Additional file 6 of Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis
Creators: name: Liu, Xinpeng
name: Jiang, Lili
name: Zhang, Wenxuan
name: Zhang, Jiahui
name: Luan, Xinrui
name: Zhan, Yuanbo
name: Wang, Tuo
name: Da, Junlong
name: Liu, Lixue
name: Zhang, Shujian
name: Guo, Yuyao
name: Zhang, Kai
name: Wang, Zhiping
name: Miao, Nan
name: Xie, Xiaohua
name: Liu, Peihong
name: Li, Ying
name: jin, Han
name: Zhang, Bin
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6. Fig. S6 The changes of Calpastatin/Calpain proteolysis system in human 293T cells after Fam20c knock out
MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer
Creators: name: Li, Changwen
name: Peng, Sen
name: Tang, Chuangang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Breast cancer (BC) is a common malignancy among women, and microRNAs (miRNAs) play a role in its progression. Reportedly, microRNA-4521 (miR-4521) participates in regulating the progression of some carcinomas. In the present work, miR-4521 and hepatoma up-regulated protein (HURP) mRNA expressions in BC tissues and cell lines were examined by qRT-PCR. After miR-4521 was overexpressed or knocked down in BC cells, CCK-8 experiment and EdU experiment were employed to detect BC cell growth. Moreover, the Transwell assay was adopted to detect the migration and invasion. Subsequently, flow cytometry was executed to evaluate the changes in cell cycle progression. KEGG analysis was utilized to predict the signaling pathways related with the target genes of miR-524-5p. The binding relationship between miR-4521 and HURP 3ʹUTR was validated by dual-luciferase reporter gene experiment. HURP and NF-kB p65 protein expression in BC cells was detected by Western blot. It was revealed that, miR-4521 was lowly expressed in BC tissues, and its expression was associated with tumor grade, lymph node metastasis and clinical stage of the patients. Overexpression of miR-4521 suppressed the growth, migration, invasion and cell cycle progression of BC cells and restrained p65 expression; downregulation of miR-4521 in BC cells showed opposite biological effects. Additionally, HURP was a downstream target gene of miR-4521, and overexpression of HURP reversed the above effects of miR-4521 overexpression. In short, miR-4521 can inhibit BC progression by modulating the HURP/NF-κB pathway.
Retracted article: MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer
Creators: name: Li, Changwen
name: Peng, Sen
name: Tang, Chuangang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Changwen Li, Sen Pengb, and Chuangang Tanga. MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer. Bioengineered. 2021 Oct. doi: 10.1080/21655979.2021.1996016. Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article. When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record’s integrity, we are retracting the article. All authors listed in this publication have been informed. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted.’
Additional file 1 of Cancer morbidity and mortality trends in Trinidad and Tobago (2008–2018)
Creators: name: Gopaul, Chavin D.
name: Singh, Aruna
name: Williams, Akil
name: Ventour, Dale
name: Thomas, Davlin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 1: SPSS outputs of cancer mortality in Trinidad and Tobago from 2008 to 2018.
Tiburtius, Valerianus, and Maximus, martyrs of Rome associated with Caecilia, buried on the via Appia
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2015
Subjects: History

description: All evidence related to Tiburtius, Valerianus, and Maximus, martyrs of Rome associated with Caecilia, buried on the via Appia.
Memória política: 100 anos de Leonel Brizola
Creators: name: Albertin de Moraes, Isaías
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Brazil
subject: Economics
subject: Latin America

description: Este dossiê, Memória Política: 100 anos de Leonel Brizola, é um movimento de rememoração estimulado por um acontecimento do presente, o aniversário de nascimento de um dos maiores personagens políticos do Brasil. Embora Brizola tenha nascido há 100 anos e tenha falecido em 2004, ele ainda está vivo, atuando e interpretando o Brasil contemporâneo. Este dossiê temático não é um resgate do pensamento de Leonel Brizola, tampouco um trabalho biográfico. É um documento que apresentou esquemas de lembranças e buscou memórias.
Supplemental Material, sj-pdf-1-jpp-10.1177_0897190020961292 - Expanding Student Knowledge and Confidence on Dietary Supplements Through Mock Patient Consultations
Creators: name: Walsh, Kendra
name: Cohen, Lisa
name: Hume, Anne L.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-jpp-10.1177_0897190020961292 for Expanding Student Knowledge and Confidence on Dietary Supplements Through Mock Patient Consultations by Kendra Walsh, Lisa Cohen and Anne L. Hume in Journal of Pharmacy Practice
“Translator of Soliloquies: Fugues in the Key of Dissociation”
Creators: name: Chu, Seo-Young
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Creative writing
subject: Psychology
subject: FOS: Psychology
subject: Asian Americans
subject: Dreams

description: Chu, Seo-Young. “Translator of Soliloquies: Fugues in the Key of Dissociation” (chapbook). Black Warrior Review 46.2, Spring 2020.
Two new C19-diterpenoid alkaloids from Delphinium potaninii var. bonvalotii
Creators: name: Ye, Li-Li
name: Long, Qiao
name: Chang, Ye
name: Li, Ting-Ting
name: Chen, Lin
name: Huang, Shuai
name: Zhou, Xian-Li
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Two previously unreported C19-diterpenoid alkaloids, bonvalotizines A and B (1–2), together with fourteen previously identified compounds (3–16) were obtained from the plant of Delphinium potaninii var. bonvalotii (Franch.) W.T. Wang. Structural characterisation of the new compounds was achieved through spectroscopic analysis, including NMR (1D and 2D), HR-ESI-MS, and IR techniques. Biological evaluation revealed that none of the isolated compounds exhibited notable suppression of NO production in RAW 264.7 macrophages induced with lipopolysaccharide (LPS).
Translator of Soliloquies: Fugues in the Key of Dissociation
Creators: name: Chu, Seo-Young
Publisher: name: unknown
Year: 2020
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Asian Americans
subject: Dreams
subject: Creative writing

description: Chu, Seo-Young. "Translator of Soliloquies: Fugues in the Key of Dissociation" (chapbook). Black Warrior Review 46.2, Spring 2020.
Competencias digitales para la elección de un programa de formación postmedia
Creators: name: Sánchez Vega, Gynne Milena
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Competencias escolares - Casos de estudio
subject: Educación secundaria - Colombia
subject: Planes de estudio - Enseñanza
subject: Orientación profesional
subject: Competencias digitales
subject: Conducta exploratoria
subject: Elección de carrera

description: El objetivo de este estudio es presentar el análisis descriptivo de las competencias digitales relevantes dentro del proceso de elección de programa de formación superior en estudiantes de último año escolar de dos colegios de Bogotá, Colombia. Con una metodología cualitativa y un diseño fenomenológico, la investigación tuvo un alcance descriptivo analítico y utilizó un análisis documental, dos cuestionarios y la entrevista en profundidad para la recolección de información. La muestra estuvo conformada por estudiantes de último grado de educación media, con 203 estudiantes indagados con un cuestionario de competencias digitales, 200 con cuestionario de conducta exploratoria y 11 estudiantes con una entrevista semiestructurada. Principalmente, el análisis cualitativo indica que las competencias digitales desempeñan un papel significativo en los procesos de OSO en estudiantes de educación secundaria media superior. Al mismo tiempo, se resalta la posibilidad y necesidad de promover el aprovechamiento de las tecnologías de la información y comunicación (TIC) por medio de OSO, para atender las necesidades ocupacionales de los estudiantes en este nivel educativo. En conclusión, la enseñanza de TIC en OSO permite fortalecer significativamente las habilidades que contribuyen a una mejor planificación en la elección de programas de formación postmedia.
description: It is the objective of this study to present a descriptive analysis of the relevant digital competencies of last year's high school students from two schools in Bogotá, Colombia, within their higher education election process. With a qualitative methodology and a phenomenological study design, the investigation had an analytical descriptive scope and employed documentary analysis, two questionnaires, and an in-depth interview for data collection. The sample consisted of students in the last grade of secondary education, with 203 students inquired through a digital competencies questionnaire, 200 through an exploratory behavior questionnaire, and 11 through a semi-structured interview. Mainly, the (X) qualitative analysis indicates a significant role of digital competencies in the SOC processes given to students of senior secondary school. At the same time, it is highlighted the possibility and necessity of promoting information and communications technologies (ICT) through SOC, to meet the occupational needs of students at this educational level. Overall, the teaching of OCT in SOC allows a significant strengthening of skills that contribute to a better planning in the process of higher education programs election.
ÉTICA DESDE UMA PERSPECTIVA MULTIDISCIPLINAR: DESAFIOS ÉTICOS NA AVALIAÇÃO DE DESEMPENHO E REMUNERAÇÃO
Creators: name: Maria Isabel dos Santos Rodrigues António
Publisher: name: Zenodo
Year: 2025

description: Este artigo aborda sobre a ética, a partir de uma perspectiva multidisciplinar, com destaque aos desafios da avaliação de desempenho em questões de remuneração, que faz parte de uma abordagem de recursos humanos. O objectivo geral desta pesquisa consiste em analisar os desafios éticos associados à avaliação de desempenho e à gestão da remuneração nas organizações. O principal problema são as dificuldades que as organizações têm em implementar sistemas que promovam uma gestão ética, o que leva à insatisfação, desmotivação e perda de confiança entre os trabalhadores. Promover a ética na avaliação e remuneração cria confiança entre empregadores e funcionários, contribui para um ambiente de trabalho mais saudável e produtivo. Deste modo, enfrentar os desafios éticos exige uma abordagem estratégica que valorize a meritocracia e o respeito dos direitos dos trabalhadores, e assegura que as decisões tomadas sejam imparciais e orientadas por valores humanísticos e organizacionais.
La identidad del orientador escolar en el paradigma emergente
Creators: name: Herrera Alfonso, Henry Alberto
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Orientación estudiantil - Enseñanza
subject: Relaciones maestro - Estudiantes
subject: Educación - Estudios de caso
subject: Opinión social
subject: Orientación escolar
subject: Rol del orientador escolar
subject: Funciones de la orientación
subject: Paradigma emergente

description: El presente trabajo, pretende la comprensión de la realidad y los eventos que rodean el fenómeno de la orientación escolar, en el colegio Cúndinamarca, a través de lo que manifiestan las opiniones de favorabilidad de la comunidad escolar. El análisis de estas opiniones, permitió identificar, que existe divergencia entre las disposiciones de la legislación nacional para el desempeño del rol de la orientación escolar, y el ejercicio real adelantado por los orientadores en algunas actividades desarrolladas en la institución. La contrastación entre las funciones realizadas y lo establecido en la norma, registró un nivel de congruencia del 73,6% de favorabilidad; percibiendo un conocimiento parcial sobre las actividades y el rol que desempeña la orientación escolar en el colegio, sin embargo, la comunidad escolar, considera importante la presencia y la participación de la orientación educativa en el ejercicio escolar. A partir de las nociones de desarrollo humano, y enfoque emergente, se establece la necesidad de definir un modelo de orientación, que descubra al ser humano más allá de las condiciones problémicas que lo puedan afectar; un modelo de orientación, que asuma un sujeto integral, autorrealizado, dotado de bienestar psicológico, eficaz, con sentido de vida, solidario y con capacidades convivencia.
description: The present work aims to understand the reality and the events that surround the phenomenon of school guidance, in the Cundinamarca school, through what the favorable opinions of the school community manifest. The analysis of. these opinions, allowed us to identify that there is a divergence between the provisions of the national legislation for the performance of the role of school guidance, and the actual exercise carried out by the counselors in sorne activities developed in the institution. The contrast between the functions carried out and what is established in the norm, registered a level of congruence of 73.6% _of favourability; Perceiving a partial knowledge about the activities and the role that school guidance plays in the school, however, the school community considers the presence and participation of educational guidance in the school exercise important. From the notions of human development, and emerging approach, the need to define an orientation model is established, which discovers the human being beyond the problematíc conditions that may affect it; an orientatíon model that assumes an integral subject, self-fulfilled, endowed with psychological well-being, effective, with a sense of life, supportive and with coexistence capacities.
Comparison between conventional, grinding, and microwave synthesis of methylpyrazoles as VEGFR-2/HSP90 dual inhibitors
Creators: name: Husseiny, Ebtehal M.
name: Abdelnaby, Rana M.
name: Altwaijry, Najla
name: Saleh, Asmaa
name: Anwer, Kurls E.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences

description: Embracing structure extension and substitution variation, methylpyrazolones 2–6 and dimethylpyrazoles 8–14 were synthesized as VEGFR-2/HSP90 dual inhibitors. The eco-friendly synthesis of the desired analogs was performed by conventional, grinding, and microwave-assisted methods. All entities have been tested for their antitumor action against three carcinomas, whereas compounds 6, 12, and 13 showed significant cytotoxicity and selectivity toward the examined carcinomas. The consecutive molecular mechanistic studies proved that 6 and 12 exhibited dual inhibition of VEGFR-2 and HSP90 and prompted MCF-7 cycle arrest at G2/M phase followed by apoptosis stimulation. Molecular docking revealed strong interaction between the potent analogs and VEGFR-2/HSP90 active sites inspiring these congeners to be potential drug candidates in cancer treatment.
Supplementary_material – Supplemental material for Social and Economic Costs of Attention-Deficit/Hyperactivity Disorder Across the Lifespan
Creators: name: Sciberras, Emma
name: Streatfeild, Jared
name: Ceccato, Tristan
name: Pezzullo, Lynne
name: Scott, James G.
name: Middeldorp, Christel M.
name: Hutchins, Paul
name: Paterson, Roger
name: Bellgrove, Mark A.
name: Coghill, David
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary_material for Social and Economic Costs of Attention-Deficit/Hyperactivity Disorder Across the Lifespan by Emma Sciberras, Jared Streatfeild, Tristan Ceccato, Lynne Pezzullo, James G. Scott, Christel M. Middeldorp, Paul Hutchins, Roger Paterson, Mark A. Bellgrove and David Coghill in Journal of Attention Disorders
Additional file 2 of MetaPro: a scalable and reproducible data processing and analysis pipeline for metatranscriptomic investigation of microbial communities
Creators: name: Taj, Billy
name: Adeolu, Mobolaji
name: Xiong, Xuejian
name: Ang, Jordan
name: Nursimulu, Nirvana
name: Parkinson, John
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Additional file 2: Fig. S2.Gene annotation performance of MetaPro, HUMAnN3, and HUMAnN2. Stacked barcharts depicting the number of reads annotated to specific taxa in (A) NOD mouse samples, and (B) Kimchi samples by BWA alignments, MetaPro, HUMAnN3, and HUMAnN2. The NOD mouse datasets were generated from gut samples from mice inoculated with a defined microbial consortium (Altered Schaedler Flora (ASF); [29]). In addition to the 8 taxa associated with ASF, reads were also assigned to Parabacteroides goldsteinii, a close relative of Parabacteroides ASF519 (see legend). The kimchi datasets comprise five major taxa (see legend; [30–34]). It should be noted that Leuconostoc gasicomitatum reported in the original publication is currently classified as a subspecies of Leuconostoc gelidum. For NOD sample SRR1828965, HUMAnN3 did not annotate any reads; for kimchi sample SRR443366, HUMAnN2 did not annotate any reads.
sj-docx-1-gsj-10.1177_2192568220962435 – Supplemental Material for Delayed Ejaculation After Lumbar Spine Surgery: A Claims Database Analysis
Creators: name: Bhambhvani, Hriday P.
name: Kasman, Alex M.
name: Zhang, Chiyuan A.
name: Hu, Serena S.
name: Eisenberg, Michael L.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material, sj-docx-1-gsj-10.1177_2192568220962435 for Delayed Ejaculation After Lumbar Spine Surgery: A Claims Database Analysis by Hriday P. Bhambhvani, Alex M. Kasman, Chiyuan A. Zhang, Serena S. Hu and Michael L. Eisenberg in Global Spine Journal
An online teacher-made workshop for students critical listening skills
Creators: name: Girón-Rubio, Hernán Mauricio
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Estudiantes - condiciones sociales
subject: Educación secundaria - Fines y objetivos
subject: Pedagogía - Enseñanza
subject: Desarrollo de materiales
subject: Escucha crítica
subject: Habilidades de escucha

description: Esta investigación de acción cualitativa analizó las habilidades de escucha crítica de los estudiantes de 8º grado en relación con la implementación de un taller en línea hecho por el maestro. El estudio se realizó con 14 alumnos de octavo grado del Colegio Rogelio Salmona IED. La mediación de los estudiantes, el diario de campo del docente y el protocolo de pensamiento en voz alta, fueron los instrumentos de recolección de datos utilizados. Los hallazgos sugieren que los estudiantes desarrollaron sus habilidades de escucha crítica y la habilidad para expresar sus puntos de vista a través de la realización de actividades, tales como comparar, inferir, evaluar y transformar la realidad. Además, los estudiantes expresaron sus puntos de vista sobre textos orales. Finalmente, los materiales de enseñanza de inglés como lengua extranjera fueron apropiados como fuente fundamental para la transformación de sus realidades en razón a su contenido e imágenes contextualizados y el uso consciente de estrategias de aprendizaje.
description: This qualitative action research analyzed 8th graders’ critical listening skills in relation to the implementation of an online teacher made workshop. It was conducted with 14 eighth graders from Rogelio Salmona IED School. Students’ mediation, teacher field notes, and think aloud protocol were the data collection instruments used. Findings suggest that students’ critical listening skills and points of view were built through activity completion such as comparing, inferring, assessing, and transforming reality. Students also expressed their points of view about spoken texts. Finally, EFL materials otherwise were appropriate as a source for students’ transformations of realities; in particular, contextualized content and images and the conscious use of learning strategies and technology lead students to transformation of realities.
Supplemental Material, Supplemental_Table_2 - Delayed Ejaculation After Lumbar Spine Surgery: A Claims Database Analysis
Creators: name: Bhambhvani, Hriday P.
name: Kasman, Alex M.
name: Zhang, Chiyuan A.
name: Hu, Serena S.
name: Eisenberg, Michael L.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material, Supplemental_Table_2 for Delayed Ejaculation After Lumbar Spine Surgery: A Claims Database Analysis by Hriday P. Bhambhvani, Alex M. Kasman, Chiyuan A. Zhang, Serena S. Hu and Michael L. Eisenberg in Global Spine Journal
20-0382_supplementary_table – Supplemental material for Sex-Related Anatomical Feasibility Differences in Endovascular Repair of Thoracoabdominal Aortic Aneurysms With Multibranched Stent-Grafts
Creators: name: Grandi, Alessandro
name: Carta, Niccolò
name: Cambiaghi, Tommaso
name: Bilman, Victor
name: Melissano, Germano
name: Chiesa, Roberto
name: Bertoglio, Luca
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Cardiology
subject: Medicine
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, 20-0382_supplementary_table for Sex-Related Anatomical Feasibility Differences in Endovascular Repair of Thoracoabdominal Aortic Aneurysms With Multibranched Stent-Grafts by Alessandro Grandi, Niccolò Carta, Tommaso Cambiaghi, Victor Bilman, Germano Melissano, Roberto Chiesa and Luca Bertoglio in Journal of Endovascular Therapy