cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Immune recognition of the bacterial type III secretion system in human cell types involved in inflammatory bowel disease and colorectal carcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the strongest correlations between chronic inflammation and malignancy is the predisposition of patients with inflammatory bowel disease (IBD) to colorectal carcinoma. IBD is thought to arise from imbalance of the microbiota and the intestinal immune system. Intestinal homeostasis is normally maintained by tolerating or keeping the beneficial microbiota in check while eliminating pathogenic microbes. Pattern recognition receptors (PRRs) expressed on many different human cells types, including macrophages and intestinal epithelial cells (IECs), largely control these selective responses. One important example is PRR recognition of specialized secretion systems, such as the type III secretion system (T3SS), expressed only by bacterial pathogens. Yet how T3SS recognition occurs remains unclear. Much of the work to characterize T3SS sensing has been carried out in mouse cells or human embryonic kidney 293T cells, yet important differences between mouse and human PRRs have been reported. We propose to analyze the ability of human macrophages and polarized IECs to produce pro- and anti-inflammatory cytokines in response to T3SS-expressing gut pathogens. We will use the two human enteropathogens Yersinia pseudotuberculosis and Y. enterocolitica, which have been implicated in mimicking IBD symptoms and co-associating with IBD in humans, yet paradoxically protect against colitis in a mouse model of infection. Our preliminary data show that nonpolarized human IECs produce the inflammatory chemokine IL-8 in response to T3SS+ Y. pseudotuberculosis, but not to a T3SS- mutant. Thorough characterization of the interaction between the Yersinia T3SS and relevant human cell types will provide critical information on the role of T3SS sensing in promoting or repressing IBD and cancer. Aim 1: Determine the innate immune response of human IECs to the Yersinia T3SS. 1.1: Production of innate immune molecules linked to IBD (IL-1ß and IL-8) will be measured in polarized IEC cell lines infected apically or basolaterally with T3SS+ and T3SS- enteropathogenic Yersinia. 1.2: The host pathway responsible for induction of IL-8 in nonpolarized IECs will be identified using MAP kinase and NF?B inhibitors as well as RNAi against known PRRs. Aim 2: Determine the innate immune response of human macrophages to the Yersinia T3SS. 2.1: Human macrophage cell lines will be infected with T3SS+ and T3SS- enteropathogenic Yersinia and secretion of innate immune molecules linked to IBD (TNF-a, IL-1ß, and IL-10) will be measu
Inhibition of the platelet derived growth factor receptor alpha signaling cascade for the treatment of pediatric gliomas
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In children, astrocytomas are the most common childhood CNS tumor representing approximately half of all pediatric brain tumors. Although advances in treatment have led to improved survival for children with brain tumors, those with high-grade gliomas (HGG) by and large succumb to their disease. If HGGs occur in the pons, tumors called diffuse intrinsic pontine gliomas (DIPGs), outcome is even worse resulting in inevitable death. Recent analyses of larger series of pediatric HGGs, including DIPGs, have highlighted PDGFRa and its downstream effector pathways PI3K/Akt/mTOR and MAPK/MEK/ERK as important targets. In preliminary work we have shown that treatment with the neutralizing anti-PDGFRa monoclonal antibody IMC-3G3 enhances the anti-neoplastic effects of radiation in the treatment of malignant gliomas. Our first hypothesis is that adding a PI3K/Akt/mTOR (XL765) or a MAPK/MEK/ERK (GSK1120212) to IMC-3G3 + radiation therapy will further enhance cytotoxicity of this combination. We will use clonogenic assays for our in vitro experiments and established orthotopic pediatric HGG models including a DIPG xenograft for in vivo analysis of the anti-cytotoxic effect of these agents alone as well as in combination. Furthermore, two principal signaling cascades emanating from PDGFRa (PI3K/Akt/mTOR and MAPK/MEK/ERK) have been shown to directly affect DNA repair components such as the Non-homologous end-joining (NHEJ) pathway and the homologous recombination DNA repair pathway (HR). NHJE is characterized by binding of Ku70/80 to double strand DNA breaks (dsDNA) in complex with DNA-PKs that in turn recruit a myriad of DNA repair enzymes such as Artemis, XRCC4 and XLF. Rad51 is primarily involved in HR and in homology search and strand exchange at sites of dsDNA breaks. Therefore, our second hypothesis is that IMC-3G3 enhances the cytotoxicity of radiation through direct effects on the DNA repair machinery. Double strand DNA breaks will be measured by formation of ?-H2AX foci in treated and control cells. To evaluate the role of specific DNA repair enzymes we will assess expression of key elements of DNA repair pathways such as Ku heterodimer (Ku70/Ku80), DNA PKs, ligase IV, XRCC4, XLF and Artemis for NHEJ and Rad51 for HR in these cells. In collaboration with Dr. Murnane, Department of Radiation Oncology, UCSF we will measure competence of NHEJ repair. To assess the role of cell cycle checkpoints we will evaluate cell cycle distribution using FACS analysis after treatment with IMC-3G3, XL765 and GSK1120212.
Exploring the Development of the Listening Skill through Blended Learning among English Language Teacher Trainees in National Teacher Colleges in Uganda
Creators: name: Egonga Badhaga, Saleh
Publisher: name: Makerere University
Year: 2024
Subjects: subject: Listening comprehension

description: Understanding listening is, a majorly combined skill that plays an active role in language learning and strengthening other language skills. Beyond being viewed as a hearing activity limited to 'sound-word' processing and learning of language from oral utterances, the skill must be continuously and changeably trained following the times. This study therefore undertook to find out whether blended learning can support, develop, enhance delivery and better assessment of multimodal listening within English language classes of teacher trainees. This study looked at three objectives; to find out the perceptions of participants towards blended learning in their listening classes, to analyse the role of blended learning in the development of listening skill learning resources, and to examine ways in which blended learning aids the listening skill assessment and evaluation of teacher trainees. The study used a purely qualitative descriptive single case study design. The study focused on only one national teachers' college which was purposively selected. The study participants were 19; 4 teacher trainers, 8 teacher trainees, and 1 focus group discussion which had 7 participants. Observation of classroom lessons, semi-structured interviews of teacher trainers and teacher trainees, Focus Group Discussions of teacher trainees, and Document analysis were the major data collection methods used. Data was analyzed through thematic analysis. Data findings revealed that several listening blended modes and resources that were used to teach listening like face-to-face and audiovisuals, were greatly effective when used as they increased the teacher trainees listening responses and engagement. Meanwhile, challenges related to connectivity, technological barriers, exposure, and inadequate resources were also identified. In conclusion, the evidenced blended learning enhanced the listening skill development among the teacher trainees and trainers. The study recommended a multimodal form of assessment of the listening skill, allocation of more time and resources to the development of the listening skill, and a clear criterion to be established for developing and selecting listening materials.
Design and synthesis of silicon-containing peptidomimetics as improved cancer-targeting agents
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This proposal will design and synthesize silicon-containing peptidomimetics to investigate the incorporation of silicon as a general strategy to design more specific and potent anti-cancer therapeutics. We hypothesize that strategic synthetic methods to incorporate lipophilic silyl groups will enhance cancer-targeting abilities, and also provide a functional handle for new linker technology and rapid preparation of 18F derivatives for molecular imaging. Although sporadic and intriguing preliminary results supporting this hypothesis have been reported, there is no systematic study comparing lipophilicity and biological activity of silicon-containing molecules of interest for cancer research. This proposal will initially focus on the synthesis, lipophilicity comparison, and binding studies to compare clinical promise for several classes of silicon-containing RGD peptidomimetics as agents for cancer-targeting and molecular imaging. Key features include the development of a novel ring-closing dihydrosilylation reaction to synthesize unnatural silicon-containing amino acids, and use of the fluoride-accepting properties of organosilanes to overcome the challenge of using short-lived 18F isotopes for molecular imaging probes. Based on the anticipated preliminary success, we have active future plans to collaborate and perform more through biological evaluation (organ specificity studies, etc; however not specifically proposed in this scope of work). The overall goal is to develop strategies to incorporate silyl groups that will demonstrate the role of silicon to improve tumor targeting and pharmacokinetics of cancer therapeutics. The Specific Aims for the proposed research are: 1) Synthesize arginine–glycine–aspartic acid (RGD) peptidomimetics incorporating silyl amino acids (e.g. TMS-alanine) to measure lipophilicity and compare binding and specificity to integrin receptors. 2) Develop a novel ring-closing dihydrosilylation reaction for the synthesis of unnatural cyclic silicon-containing amino acids, which will be incorporated in cyclic RGD peptidomimetics to measure lipophilicity and compare binding and specificity to integrin receptors. 3) Demonstrate hydrosilylation linker technology for cyclic RGD conjugates. 4) Use the fluoride-accepting properties of organosilanes to overcome the challenge of using short-lived 18F isotopes for molecular imaging probes by synthesizing silicon-containing RGD analogues for 18F labeling studies.
Additional file 6: Figure S5. of Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption
Creators: name: Brown, Elizabeth
name: Patterson, Cody
name: Rayanne Pancoast
name: Rollmann, Stephanie
Publisher: name: Figshare
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Dry mass and measurements of metabolism. (a, b) Dry mass (N = 10), (c, d) adjusted triglyceride levels (N = 3), (e, f) adjusted glucose (N = 3), and (g, h) adjusted glycogen measurements (N = 3) for lines selected for increased and decreased behavioral responses to 4-ethylguaiacol and 4-methylphenol. Data shown are means ± SE for females and males (left and right columns, respectively). Letters indicate P
Dichotomius (Cephagonus) periotoi Nunes
Creators: name: Nunes, Rafael V.
name: Vaz-de-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dichotomius
Dichotomius periotoi

description: 4.5.: Dichotomius (Cephagonus) periotoi Nunes & Vaz-de-Mello 2016 new combination(Figure 41 (e))
Dichotomius (selenocopris) periotoi ı Nunes & Vaz-de-Melloı 2016ı p. 87 (description)
Diagnosis. In the groupı D. periotoi is separated of the other brachypterous species in the group by the following combined characters: dorsal surface shiny and usually with brown or blue reflections; cephalic carina taller than wideı with two tubercles at apex; dorsal surface of head smooth; surface of pronotal anterior excavation smoothı bearing few and sparse fine punctures and anterior portion of pronotal disc having two lobes.
Distribution. municipality of Descalvadoı state of São Pauloı BRAZIL.
description: Published as part of Nunes, Rafael V. & Vaz-de-Mello, Fernando Z., 2019, Taxonomic revision of Dichotomius (Cephagonus) Luederwaldt 1929 and the taxonomic status of remaining Dichotomius Hope 1838 subgenera (Coleoptera: Scarabaeidae: Scarabaeinae: Dichotomiini), pp. 2231-2351 in Journal of Natural History 53 (37) on page 2330, DOI: 10.1080/00222933.2019.1692088, http://zenodo.org/record/3665519
Processing of chemotherapy induced topoisomerase II-DNA adducts in yeast
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: DNA topoisomerase II is the target of the most potent chemotherapeutic drugs in clinical use today; these drugs trap topoisomerase II on its DNA substrate in a way that creates chromosomal breaks and causes cell death. Targeting topoisomerase II is a double-edged sword, however, as interference with it can lead to chromosome translocations and segregation errors that may play a causal role in promoting tumorigenesis. In addition, cells appear to have evolved robust mechanisms that allow them to detect and repair aberrant topoisomerase II-DNA complexes. In this manner, cells escape or circumvent the genotoxic effects of the drugs. A more complete understanding of how cells respond to and survive topoisomerase II -directed chemotherapies is needed to improve their efficacy. In this application we describe evidence that SUMO modification of a non-catalytic C-terminal region of topoisomerase II may be involved in responding to drug-induced topoisomerase II-DNA adducts. Based on a variety of observations, we postulate that this region of topoisomerase II is likely to possess a DNA binding activity that helps target the enzyme to DNA nodes or strand junctions. In response to perturbations to catalysis, such as would occur when the enzyme becomes trapped as a topoisomerase II-DNA adduct, the C-terminal region is targeted for sumoylation as a means to dissociate it from DNA and potentially also to signal subsequent proteolytic processing of the trapped enzyme. Our first aim proposes experiments that will allow us to assess this model. We have also found that accumulation of topoisomerase II-DNA adducts is associated with robust activation of the spindle assembly checkpoint. A similar phenomenon is observed in mammalian cells, and our second aim consists of experiments to test hypotheses for how topoisomerase II trapped on DNA could lead to activation of the this checkpoint pathway. The work proposed here is not duplicated in any other proposal from my lab. My hope is that securing CRCC funding will allow me to develop the topoisomerase II sumoylation/topoisomerase II drug interaction to a point where it provides a robust third aim for a larger NIH proposal on topoisomerase II.
Additional file 1: of Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections
Creators: name: Lerch, Anita
name: Koepfli, Cristian
name: Hofmann, Natalie
name: Messerli, Camilla
name: Wilcox, Stephen
name: Kattenberg, Johanna
name: Inoni Betuela
name: OâConnor, Liam
name: Mueller, Ivo
name: Felger, Ingrid
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supporting information. Supplementary text, figures and tables. (DOCX 2111Â kb)
Onoreodrilus loksai Zicsi 1988
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Onoreodrilus
Onoreodrilus loksai

description: Onoreodrilus loksai Zicsi, 1988
Onoreodrilus loksai Zicsi, 1988d Acta Zool. Hung. 34 (1): 61.
Onoreodrilus loksai: Zicsi 1990c Mitt. hamb. zool. Mus. Inst. 87: 151.
Onoreodrilus loksai: Zicsi & Feijoo 1994 Mitt. hamb. zool. Mus. Inst. 89 (Ergbd 2): 59.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Dichotomius (Cephagonus) spadiceus
Creators: name: Nunes, Rafael V.
name: Vaz-de-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dichotomius
Dichotomius spadiceus
Pinotus

description: Group 5: Dichotomius (Cephagonus) spadiceus (Luederwaldt) species-group
Diagnosis. species of this group are separated of other Cephagonus by the combination of following characters: posterior angle of pronotum excavated and bearing groups of 5 ocellate punctures; clypeo-genal angle obtuse (as on D. fissus and D. ascanius groups); larger males pronotal disc with central emargination at anterior portion (as D. socius) (Figure 43 (aıf)); males pronotal anterior excavation and declivity smoothı lacking coarseı ocellate punctures or striations; elytra striae flatı weakly impressed (as D. fissus group); females sixth abdominal ventrite posterior margin with a central emargination producing two triangular projections advancing beneath pydigium margin (like on D. (s.) fissus) and female sixth ventrite disc with fine puncture medially (viewed under 20x magnification) and having a pair of triangular projections advancing beneath the pygidium margin (Figure 9 (b)). Species of D. spadiceus group are similar to D. fissus and D. socius (ascanius group)ı maybe because of their elytral striae and pronotum anterior emargination. Howeverı they are smaller (maximum BL = 15 mmı PW = 9 mm)ı lack coarse or ocellate punctures on the pronotal anterior portion. Other important difference among these species is the shape of female sixth ventriteı which is less wide on spadiceus species group than it is on fissus group.
Representatives. 5.1: D. spadiceus; 5.2: D. itatiaiaensis; 5.3: D. lucianomourai.
description: Published as part of Nunes, Rafael V. & Vaz-de-Mello, Fernando Z., 2019, Taxonomic revision of Dichotomius (Cephagonus) Luederwaldt 1929 and the taxonomic status of remaining Dichotomius Hope 1838 subgenera (Coleoptera: Scarabaeidae: Scarabaeinae: Dichotomiini), pp. 2231-2351 in Journal of Natural History 53 (37) on page 2330, DOI: 10.1080/00222933.2019.1692088, http://zenodo.org/record/3665519
Tumor hypoxia regulates HER3 expression and function
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer of the oral cavity is in the top ten most frequently diagnosed cancers worldwide with over 200,000 deaths annually. For the past several decades, the 5-year survival rate for this progressive and disfiguring disease has remained around 50% with little advancement in diagnostic or treatment strategies. Clearly, there is an urgent need to develop novel molecular targets that yield new effective therapeutic approaches. Oral squamous cell carcinomas (OSCC) generally express high levels of human epidermal receptor (HER) family members that are involved in regulating growth and metastasis. HER-targeted therapies have shown significant clinical effectiveness in a subset of patients with oral cancer, but ultimately these tumors become unresponsive to treatment. The central goal of this project is to understand the mechanisms that regulate HER signaling that promotes tumor cell growth and to define the complex cellular interrelationships that contribute to development of resistance to inhibitors targeting HER axis family members. This project evolved from a realization that in the tumor nest hypoxic milieu cancer cells can escape chemotherapeutic targeting by triggering the reprogramming and switching in HER family member expression that may result to altered ligand-dependent receptor association pattern switching and signaling. Our hypothesis is that in high density hypoxic tumor cell nests promote specific HER family signaling profiles favoring enhanced proliferation and resistance to chemotherapeutic agents. To address this hypothesis, we propose the following two aims: 1) What is the mechanism regulating hypoxia-dependent HER3 overexpression, and 2) How does HIF-1a-induced HER switching modulate tumor cell resistance to targeted chemotherapy? To establish that hypoxia regulates HER3 expression through HIF-1, we will employ shRNA-mediated depletion of HIF-1a and ectopic HIF-1a overexpression approaches followed by HER3 promoter assays. HIF-1a-induced HER3 modulation and signaling will be studied using receptor cross-linkage, immunoprecipitations and immunoblotting assays. The role of HIF-1a-induced HER3 switch in cell growth and resistance to specific HER1-targeted inhibitors will be determined by TUNEL assay and BrdU incorporation approaches. These proposed studies should foster an increased understanding of tumor progression that could be the exploited for future development of noveltherapeutic strategies for oral SCC and other cancers.
Sema3E-mediated epithelial-to-mesenchymal-transition in ovarian cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer cells often employ developmental cues for advantageous growth and metastasis. Here we propose to study how semaphorin signaling confers metastatic phenotype to cancer cells. We have found that high expression of Sema3E in human high-grade ovarian endometrioid carcinoma (OEC) facilitated tumor progression. Further studies in OEC cell lines indicated that Sema3E acted through Plexin-D1 receptors to promote cellular migratory ability, and that Sema3E could confer morphological changes of OEC cells similar to epithelial-to-mesenchymal transition (EMT). The effects on morphological transition may be relevant to the mechanisms governing metastatic changes of tumors. Based on these observations, we hypothesize that axon guidance molecule Sema3E promotes tumor progression by Snail1-mediated epithelial-to-mesenchymal transition. Specific aim 1: To demonstrate that Sema3E induces EMT changes and promote tumor progression in OEC cells. We have established an arsenal of OEC stable cell lines with specific expression and deletion of Sema3E and Plexin-D1. In vitro cell migration assays will be used to establish that OEC cell migratory ability is specifically enhanced by Sema3E/plexin-D1 signaling. EMT markers will be examined in OEC cells with different Sema3E signaling activities to determine whether Sema3E-induced morphological changes are associated with an EMT event. Specific aim 2: To investigate the molecular mechanisms involved in Sema3E-mediated nuclear translocation of Snail1 and EMT in OEC cells. Our preliminary results showed that Sema3E/Plexin-D1 signaling modulated the subcellular localization of Snail1 in OEC cells. We will use both luciferase activity assay in OEC cells and in vitro cell migration assays to demonstrate Snail1 is a downstream responsive element for Sema3E/Plexin-D1 signaling in OEC cells within the context of EMT and cell motility. We will then use pharmacological approaches to explore the intracellular signaling pathway(s) that might regulate Sema3E/Plexin-D1 mediated translocation of Snail1 and subsequent EMT in OEC cells. Ultimately, understanding the molecular mechanisms underlying Sema3E mediated EMT and tumor progression will enable us to identify novel molecular markers for prediction of biological behaviors.
title: Butternut, Butternut Squash, Cheese Pumpkin, China Squash, Cushaw, Golden Cushaw, Musky Gourd, Pumpkin, Winter Crookneck Squash :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: New Varieties of Plants
Butternut Squash

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Periscolex ecuadoriensis Zicsi 1992
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Periscolex
Periscolex ecuadoriensis

description: Periscolex ecuadoriensis Zicsi, 1992
Periscolex ecuadoriensis Zicsi, 1992 Rev. suisse Zool. 99 (1): 214.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Additional file 7: Figure S6. of Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption
Creators: name: Brown, Elizabeth
name: Patterson, Cody
name: Rayanne Pancoast
name: Rollmann, Stephanie
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Categorization of differentially expressed genes among lines selected for differences in behavioral responses to 4-ethylguaiacol into (a) biological process, (b) molecular function, and (c) cellular component gene ontology terms. (PDF 18 kb)
Periscolex guayaramerinensis Zicsi & Csuzdi 1999
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Periscolex
Periscolex guayaramerinensis

description: Periscolex guayaramerinensis Zicsi & Csuzdi, 1999
Periscolex guayaramerinensis Zicsi & Csuzdi, 1999a Senck. biol. 78 (1/2): 131.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Study on Airway Microecology of Chronic Obstructive Pulmonary Disease in Inner Mongolia
Creators: name: 武鑫鑫(Xin-Xin Wu)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Multiisolate
Medical

description: Sputum samples were collected from AECOPD patients and healthy volunteers in Inner Mongolia, and airway microecology was analyzed by 16SrDNA high-throughput sequencing technology. From the analysis of alpha diversity, beta diversity and LefSe difference, the airway microecological characteristics and differences between healthy people and AECOPD patients were revealed.
Periscolex longituberculatus Zicsi 1989
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Periscolex
Periscolex longituberculatus

description: Periscolex longituberculatus Zicsi, 1989
Periscolex longituberculatus Zicsi, 1989d Rev. suisse Zool. 96: 22.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Metformin_Meta
Creators: name: 任华慧(Huahui Ren)
Publisher: name: CNGB
Year: 2024
Subjects: Metagenome
Environment
Environmental

description: The study was an open-labeled, single-arm trial conducted in Shenzhen between March 2017 and Jun 2018, which recruited 52 participants with newly diagnosed T2D from Shenzhen Peoples Hospital. The participants received a 3-month treatment with metformin, and 47 participants completed the treatment.
Single-nucleus chromatin landscapes in human multi-lineage teratoma development
Creators: name: 李金秀
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Multiisolate

description: In this study, we used human primed and naive pluripotent stem cells to generate 7 teratomas, and obtained 66,384 high-quality single-cell chromatin accessible region profiles from these teratomas. Using these data, we identified 11 cell types across embryonic and extraembryonic lineages, and the cell types displayed epigenetic features consistent with cell types at the stage of human fetal organogenesis.
Stangeleon Miller 2008, new genus
Creators: name: Miller, Robert B.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Stangeleon

description: Stangeleon Miller, new genus
(Figure 1-13)
description: Published as part of Miller, Robert B., 2008, A new genus and species of Brachynemurini from Venezuela (Neuroptera: Myrmeleontidae), pp. 1-5 in Insecta Mundi 2008 (59) on page 1, DOI: 10.5281/zenodo.5170177
Pontoscolex (Pontoscolex) franzi Zicsi & Csuzdi 1999
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Pontoscolex
Pontoscolex franzi

description: Pontoscolex (Pontoscolex) franzi Zicsi & Csuzdi, 1999
Pontoscolex (Pontoscolex) franzi Zicsi & Csuzdi, 1999a Senck. biol. 78: 132.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Additional file 1: Table S1. of Adaptation of the GoldenBraid modular cloning system and creation of a toolkit for the expression of heterologous proteins in yeast mitochondria
Creators: name: Pérez-González, Ana
name: Kniewel, Ryan
name: Veldhuizen, Marcel
name: Verma, Hemant
name: Navarro-Rodríguez, Mónica
name: Rubio, Luis
name: Caro, Elena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: (.doc) List of primers and templates used for the domestication of parts. (DOCX 17 kb)
Quimbaya calimae Zicsi & Feijoo 2002
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Quimbaya
Quimbaya calimae

description: Quimbaya calimae Zicsi & Feijoo, 2002
Quimbaya calimae Zicsi & Feijoo, 2002 Ber. nat.-med. Verein Innsbruck 89: 112.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Quimbaya gutierrezi Zicsi & Feijoo 2002
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Quimbaya
Quimbaya gutierrezi

description: Quimbaya gutierrezi Zicsi & Feijoo, 2002
Quimbaya gutierrezi Zicsi & Feijoo, 2002 Ber. nat.-med. Verein Innsbruck 89: 114.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Tamayodrilus roembkei Zicsi 1995
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Tamayodrilus
Tamayodrilus roembkei

description: Tamayodrilus roembkei Zicsi, 1995
Tamayodrilus roembkei Zicsi, 1995b Rev. suisse Zool. 102 (3): 595.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Astrida Fain 1955
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Astrida

description: Genus Astrida Fain, 1955
Astrida Fain, 1955b: 696, 1957a: 251, 1958b: 178, 1962a: 9, 1963b: 373. Type species: Astrida caprimulgi Fain, 1955 by original designation.
Diagnosis. Palps with 2 (subgen. CerylOnyssus Fain and Aitken, 1970) or 3 (subgen. Astrida Fain, 1955) segments. Hypostome with 2 pairs of setae. Propodonotal shield present. Propodonotal region with 4 (ve and se absent— CerylOnyssus) or 6 (Astrida) pairs of setae. Hysteronotal region with 5 pairs of setae (h2 absent). Genital series with 3 pairs of setae. Each agenital and pseudanal series with 2 pairs of setae. Setae 1a, 3a and 4a present. Number of leg setae: coxae 2–1–1–1 (Astrida) or 1–1–1–1 (CerylOnyssus), trochanters 1–1–0–0, femora 7–4–3–4 (Astrida) or 5–3–3–2 (CerylOnyssus), genua 4–4–3–3, tibiae 5–3–3–3. Setae situated in anterior part of tarsi I–IV normally developed.
Remarks. Species of this genus are associated with birds of the orders Caprimulgiformes, Coraciiformes, and Strigiformes, and they have been recorded in the Afrotropical, Nearctic, and Neotropical regions (Fain 1955b, 1956b, 1963c; Fain & Aitken 1970; Pence 1973b). The Afrotropical fauna comprises one of the two described species in this genus: Astrida caprimulgi Fain, 1955.
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 402, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Energy-Efficient Baseband Circuits for 60GHz Wireless Links
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: With the nearly pervasive penetration of handheld and mobile electronics, the need for these devices to support wireless (rather than wired) connectivity has become increasingly acute. Utilizing emerging multi-Gb/s links over the 60GHz band in such mobile devices to handle applications such as HDMI cable replacement, file synchronization/download, and wireless docking (using e.g. the WiGig standard) is therefore extremely attractive. Unfortunately however, the power dissipation of today’s 60GHz transceiver designs is multiple Watts – out of which roughly half of the power is dissipated in the baseband circuitry – excluding their use in mobile form factors. In this project we propose to explore system and circuit design techniques to drastically reduce the power consumed by 60GHz transceivers supporting up to ~10Gb/s. In particular, this project aims to reduce the power consumption of the baseband portion of the system to less than 75mW. This will be achieved by building upon our previous efforts in energy-efficient line-of-sight mixed-signal basebands as well as low-power non-line-of-sight digital basebands, both of which utilized optimal partitioning between analog, mixed-signal, and digital processing to drastically reduce power consumption. This project will expand upon these previous efforts by exploring the design of baseband circuitry – and in particular equalization structures – capable of efficiently handling all operating conditions over today’s frequency channelized standards. Furthermore, this project will aim to show that by utilizing these baseband designs, bonding multiple such sub-channels – i.e., utilizing the 7GHz of unlicensed spectrum available at 60GHz – is the most efficient means to further increase throughput.
Additional file 2: Table S2. of Adaptation of the GoldenBraid modular cloning system and creation of a toolkit for the expression of heterologous proteins in yeast mitochondria
Creators: name: Pérez-González, Ana
name: Kniewel, Ryan
name: Veldhuizen, Marcel
name: Verma, Hemant
name: Navarro-Rodríguez, Mónica
name: Rubio, Luis
name: Caro, Elena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: (.doc) Sequences of primers used (DOCX 15 kb)
Zongodrilus multipapillatus Zicsi 2002
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Zongodrilus
Zongodrilus multipapillatus

description: Zongodrilus multipapillatus Zicsi, 2002
Zongodrilus multipapillatus Zicsi, 2002 Opusc. Zool. (Budapest) 34: 114.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 34, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Astrida (Astrida) caprimulgi Fain 1955
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Astrida
Astrida caprimulgi

description: Astrida (Astrida) caprimulgi Fain, 1955
(Fig. 1)
Astrida caprimulgi Fain, 1955b: 696, 1956a: 33, figs. 17–20, 1956b: 646, 1962a: 9, 1963c: 61, figs. 12–13, 1963d: 25; Pence, 1973b: 879, 1973c: 886, 891. Holotype in RMCA, examined.
Type host: Caprimulgus fossii welwitschii Bocage (Caprimulgiformes: Caprimulgidae) from Rwanda.
Diagnosis. Palps with 3 segments. Palp tarsus with 3 setae (BN-type) and solenidion; palp tibia with 1 seta (BNtype). Hypostome with 2 pairs of setae (BNa-type). Setae ve situated anterior to si. Sensillae si (SBb-type), vi (BNa or BNz), ve (BDw), se (BNz), c1 (Nz), c2 (BNz). All hysteronotal setae (Nz-type). Ventral idiosomal setae (including coxal setae) BNa or BNz-type.
Hosts and distribution. Caprimulgiformes (Caprimulgidae): Caprimulgus fOssii welwitschii Bocage from Rwanda [Southern Prov., Muhero] (Fain 1956b).
Strigiformes (Strigidae): BubO africanus (Temminck), Glaucidium perlatum (Vieillot), and Otus senegalensis (Swainson) — all from Rwanda [Southern Prov., Akanyaru] (Fain 1956b).
Non-African hosts and distribution. Caprimulgidae: AntrOstOmus carOlinensis (Gmelin) from USA (Pence 1973b).
Strigidae: Otus spilOcephalus vulpes (Ogilvie-Grant) from Malaysia (Fain 1963d).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on pages 403-404, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849
Additional file 3: Figure S1. of Adaptation of the GoldenBraid modular cloning system and creation of a toolkit for the expression of heterologous proteins in yeast mitochondria
Creators: name: Pérez-González, Ana
name: Kniewel, Ryan
name: Veldhuizen, Marcel
name: Verma, Hemant
name: Navarro-Rodríguez, Mónica
name: Rubio, Luis
name: Caro, Elena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: (.doc) Sequences of parts used for transcriptional unit assembly. (DOCX 25 kb)
Conductive Polymer Binder and Silicon Composite Electrode
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Silicon has long been sought after as a material for a lithium-ion anode due to its large theoretical capacity. The primary challenge for its implementation has been managing the large volume changes of the silicon upon charge/discharge. These volume changes have typically led to mechanical cracking of the silicon, resulting in high levels of capacity fading in the cell. Dr. Liu has developed a flexible, conductive polymer binder that allows the use of silicon particles. The binders significantly improve the viability of using silicon as an electrode material in lithium ion batteries for high power and high-energy applications. When used in the fabrication of negative silicon electrodes, the Berkeley Lab binder materials deliver significantly improved high capacity Si cycle-life. When combined with high capacity positive electrode materials, the conductive binder materials promise to triple battery capacity of the state-of-art. The polymer binder improves the cycling capability of silicon by preventing electrode degradation over time. The polymer binder is conductive eliminating the needs for conductive additives and binds to the silicon particles to maintain good electronic conductivity throughout the electrode. The robust polymer binder and Si interface withstands Si particle volume change during charge and discharge. In addition, the Berkeley Lab binder materials are chemically and mechanically stable. Until now, silicon-based negative electrodes have not maintained stable capacity during cycling process. The Berkeley Lab conductive binder technologies better tolerate volume changes during cycling, and can be incompatible with current manufacturing technology.
circuit modeling and optimization at the extreme scaling
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: To address challenges at the extreme scaling of integrated circuits and systems, this project develops stochastic circuit modeling and optimization considering variations and high frequency induced impacts, especially those for analog and custom circuits used by 4G or wireless multimedia networking. This project also prototypes a mixed-level simulator for beyond die integration using silicon interposer, through silicon vias (TSVs) and 3D stacking, and performs a case study on the early-stage design exploration of memory bandwidth optimization for networking systems.
Zongodrilus silvestris
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Zongodrilus
Zongodrilus silvestris

description: Zongodrilus silvestris (Zicsi, 1995)
Martiodrilus silvestris Zicsi, 1995b Rev. suisse Zool. 102 (3): 600.
Zongodrilus silvestris: Zicsi 2002 Opusc. Zool. (Budapest) 34: 114.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 35, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Aureliania Fain 1958
Creators: name: Skoracki, Maciej
name: Schmidt, Karl-Heinz
name: Marciniak, Natalia
name: Marciniak, Martyna
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Ereynetidae
Aureliania

description: Genus Aureliania Fain, 1958
Aureliania Fain, 1958b: 177, 1962a: 9, 1963b: 373, 1985a: 146.
Type species: BOydaia aureliani Fain, 1955 by original designation.
Diagnosis. Palps with 1 segment. Hypostome with 2 pairs of setae. Propodonotal shield absent. Propodonotal region with 4 pairs of setae (ve and se absent). Hysteronotal region with 5 pairs of setae (h2 absent). Genital series with 3 pairs of setae. Pseudanal series with 2 pairs of setae. Agenital setae absent. Setae 1a, 3a present, 4a absent. Number of leg setae: coxae 1–1–1–1, trochanters 0–0–0–0, femora 4–3–3–2, genua 4–4–3–3, tibiae 5–3–3–3. Setae situated in anterior part of tarsi I–IV normally developed.
Remarks. The monotypic genus associated with birds of the order Strigiformes and recorded in the Afrotropical, Australian, Palaearctic and Panamanian regions (Fain 1955b, 1956a, 1963a, 1963d; Domrow 1969, 1991; Dusbabek & Cerny 1970).
description: Published as part of Skoracki, Maciej, Schmidt, Karl-Heinz, Marciniak, Natalia & Marciniak, Martyna, 2018, A review of mites of the subfamily Speleognathinae (Acariformes: Ereynetidae) parasitizing respiratory tracts of birds in the Afrotropical region, pp. 401-440 in Zootaxa 4403 (3) on page 404, DOI: 10.11646/zootaxa.4403.3.1, http://zenodo.org/record/1212849