Additional file 1 of A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors
Creators: name: Swift, Imogen J.
name: Rademakers, Rosa
name: Finch, NiCole
name: Baker, Matt
name: Ghidoni, Roberta
name: Benussi, Luisa
name: Binetti, Giuliano
name: Rossi, Giacomina
name: Synofzik, Matthis
name: Wilke, Carlo
name: Mengel, David
name: Graff, Caroline
name: Takada, Leonel T.
name: Sánchez-Valle, Raquel
name: Antonell, Anna
name: Galimberti, Daniela
name: Fenoglio, Chiara
name: Serpente, Maria
name: Arcaro, Marina
name: Schreiber, Stefanie
name: Vielhaber, Stefan
name: Arndt, Philipp
name: Santana, Isabel
name: Almeida, Maria Rosario
name: Moreno, Fermín
name: Barandiaran, Myriam
name: Gabilondo, Alazne
name: Stubert, Johannes
name: Gómez-Tortosa, Estrella
name: Agüero, Pablo
name: Sainz, M. José
name: Gohda, Tomohito
name: Murakoshi, Maki
name: Kamei, Nozomu
name: Kittel-Schneider, Sarah
name: Reif, Andreas
name: Weigl, Johannes
name: Jian, Jinlong
name: Liu, Chuanju
name: Serrero, Ginette
name: Greither, Thomas
name: Theil, Gerit
name: Lohmann, Ebba
name: Gazzina, Stefano
name: Bagnoli, Silvia
name: Coppola, Giovanni
name: Bruni, Amalia
name: Quante, Mirja
name: Kiess, Wieland
name: Hiemisch, Andreas
name: Jurkutat, Anne
name: Block, Matthew S.
name: Carlson, Aaron M.
name: Bråthen, Geir
name: Sando, Sigrid Botne
name: Grøntvedt, Gøril Rolfseng
name: Lauridsen, Camilla
name: Heslegrave, Amanda
name: Heller, Carolin
name: Abel, Emily
name: Gómez-Núñez, Alba
name: Puey, Roger
name: Arighi, Andrea
name: Rotondo, Enmanuela
name: Jiskoot, Lize C.
name: Meeter, Lieke H. H.
name: Durães, João
name: Lima, Marisa
name: Tábuas-Pereira, Miguel
name: Lemos, João
name: Boeve, Bradley
name: Petersen, Ronald C.
name: Dickson, Dennis W.
name: Graff-Radford, Neill R.
name: LeBer, Isabelle
name: Sellami, Leila
name: Lamari, Foudil
name: Clot, Fabienne
name: Borroni, Barbara
name: Cantoni, Valentina
name: Rivolta, Jasmine
name: Lleó, Alberto
name: Fortea, Juan
name: Alcolea, Daniel
name: Illán-Gala, Ignacio
name: Andres-Cerezo, Lucie
name: Van Damme, Philip
name: Clarimon, Jordi
name: Steinacker, Petra
name: Feneberg, Emily
name: Otto, Markus
name: van der Ende, Emma L.
name: van Swieten, John C.
name: Seelaar, Harro
name: Zetterberg, Henrik
name: Sogorb-Esteve, Aitana
name: Rohrer, Jonathan D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Supplementary Figure 1. Data collection flowchart. Supplementary Figure 2. Serum PGRN concentrations in both GRN mutation carriers (GRN) and non-mutation carriers (non-GRN). Cut-off determined using the optimal Youden’s index. Supplementary Figure 3. A) Correlation between serum and plasma PGRN levels in this cohort (p= 0.0696). B) Correlation between CSF and serum PGRN levels in this cohort (p = 0.0780). C) Correlation between CSF and plasma in this cohort (p&lt;0.0001). Supplementary Figure 4. No significant difference in plasma PGRN levels between bvFTD (behavioural variant FTD) and PPA (primary progressive aphasia) GRN mutation carriers.Supplementary Figure 5. A) Correlation between plasma PGRN levels and age at sampling in GRN mutation carriers. B) Correlation between plasma PGRN levels and age at sampling in non GRN mutation carriers. ** P &lt; 0.01,**** P &lt; 0.0001, Spearman correlation. Supplementary Figure 6. A) Correlation between plasma PGRN levels and age of onset in GRN mutation carriers. B) Correlation between plasma PGRN levels and age of onset in non-GRN mutation carriers. C) Correlation between plasma PGRN levels and age of onset in people with AD. **** P &lt; 0.0001, Spearman correlation. Supplementary Figure 7. A) Correlation between plasma PGRN levels and weight in GRN mutation carriers. B) Correlation between plasma PGRN levels and weight in non GRN mutation carriers. Supplementary Figure 8. A) Differences in plasma PGRN levels measured with the Adipogen assay between clinical diagnoses in this cohort. B) Differences in serum PGRN levels measured with the Adipogen assay between clinical diagnoses in this cohort. * P &lt; 0.05, ** P &lt; 0.01, *** P &lt; 0.001, **** P &lt; 0.0001, two-tailed Mann-Whitney Test. Supplementary Table 1. List of institutions, countries, assay types and sample types included in this dataset alongside the number of data point provided.