cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prevalence of elevated blood pressure levels in overweight and obese young population (2 - 19 years) in the united states between 2011 and 2012
Creators: name: Agyekum, Lawrence O.
Publisher: name: No Publisher Supplied
Year: 2016

description: Several studies have reported hypertension prevalence in children and adolescents in the United States (US) using regional or local population-based samples but few have reported national prevalence. The present study estimates national hypertension prevalence in US children and adolescents for 2011-2012. A convenient sample size of 4,196 (population aged ≤ 19) representing 43% of 9,756 (total survey respondents) was selected and stratified by age groups; “Children” and “Adolescents” using the 2007 Joint National Committee recommended definitions. Next, hypertension distribution was explained by gender, race, age, body weight, standing height and blood serum total cholesterol. Variations in BP levels were measured and expressed in percentiles for nominal variables and by means and standard deviations for continuous variables. Estimated national hypertension prevalence in the US for the 2011-2012 analysis period were 3% in children aged (2<=11 years) and 14% in adolescents aged (12<=19 years). Rates were highest among adolescent boys (4%) stage 1 and (7%) stage 2 and lowest among adolescent girls (2%) stage 1 and (0.86%) stage 2. Adolescent Blacks had highest relative rate (21% SE <1) compared to lowest rate of 8% in Non-Hispanic Asians. The highest BP risk factor was body weight with a t-value of 7.75 and (p
Hemodynamic gain index and risk of ventricular arrhythmias: a prospective cohort study
Creators: name: Kunutsor, Setor K.
name: Jae, Sae Young
name: Kurl, Sudhir
name: Laukkanen, Jari A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Objectives: Hemodynamic gain index (HGI), a novel hemodynamic index obtained from cardiopulmonary exercise testing (CPX), is associated with adverse cardiovascular outcomes. However, its specific relationship with ventricular arrhythmias (VAs) is unknown. We aimed to assess the association of HGI with risk of VAs in a prospective study. Design: Hemodynamic gain index was estimated using heart rate and systolic blood pressure (SBP) responses ascertained in 1945 men aged 42–61 years during CPX from rest to maximum exercise, using the formula: [(Heart ratemax x SBPmax) – (Heart raterest x SBPrest)]/(Heart raterest x SBPrest). Cardiorespiratory fitness (CRF) was measured using respiratory gas exchange analysis. Hazard ratios (HRs) (95% confidence intervals, CIs) were estimated for VAs. Results: Over a median follow-up duration of 28.2 years, 75 cases of VA were recorded. In analysis adjusted for established risk factors, a unit (bpm/mmHg) higher HGI was associated with a decreased risk of VA (HR 0.72, 95% CI: 0.55–0.95). The results remained consistent on adjustment for lifestyle factors and comorbidities (HR 0.72, 95% CI: 0.55–0.93). Comparing the top versus bottom tertiles of HGI, the corresponding adjusted HRs (95% CIs) were 0.51 (0.27–0.96) and 0.52 (0.28–0.94), respectively. The associations were attenuated on addition of CRF to the model. HGI improved risk discrimination beyond established risk factors but not CRF. Conclusions: Higher HGI is associated with a reduced risk of VAs in middle-aged and older Caucasian men, but dependent on CRF levels. Furthermore, HGI improves the prediction of the long-term risk for VAs beyond established risk factors but not CRF.
Assessing the quality of life and health outcomes of Androgenic Alopecia patients using Propecia
Creators: name: Alanazi, Naif
Publisher: name: No Publisher Supplied
Year: 2016

description: Most dermatologists prescribe the drugs Minoxidil and Propecia (Finastride) to improve the symptoms of Androgenic Alopecia in male patients, and subsequently their Quality of Life. However, it has been noticed that patients who were using Propecia have developed some serious side effects such as erectile dysfunction, lack of libido, depression and in some cases suicidal thoughts, which cause a decrease in  the Quality of Life of the patient instead of improving it.  in our study we assessed the Quality of Life of 90 Androgenic Alopecia patients who are using Propecia only and compared them to 157 Androgenic Alopecia who are using Minoxidil only. We used the self-reporting SF-36 Quality of Life Scale and added the variables Age, Duration of Using Propecia and Patients’ Compliance. We found a statistical significance decrease in the Quality of Life of patients using Propecia in comparison to patients using Minoxidil. The Role Limitation Due to an Emotional Problem was the most effected health component of the SF-36 Quality of Life scale.  Also we found a correlation between the duration of using Propecia and the worsening of the Quality of Life score. Ages of the patients and their compliance were not found to be related to the score.
Design and development of a palatal rugae based biometric identification system
Creators: name: Assiri, Essa A.
Publisher: name: No Publisher Supplied
Year: 2016

description: Background: In the field of forensic odontology, palatal rugae plays a promising role in extracting identifications. The advantage of using 3D images of the palatal rugae is the accurate measurement results. Furthermore, the multi-shapes abstraction of the palatal rugae makes it easier to handle and analyze for the purpose of auto-shape-detection in the future. In doing so all the currently recognized criteria of biometrics science will be fulfilled in order to consider the palatal rugae recognition as one of the novel biometric technology.    Objectives: To investigate the unique features of the palatal rugae’s shapes and measurements and use it to establishing a landmark for extracting biometrics based identification.    Design: An intra-oral scan images used to get a 3D model replica of the upper jaw to come up with a set of biometrical features for use in classification and detection.    Methods: The study consists of 24 subjects, 12 males and 12 females, which are used to validate the workflow of the biometrics based identification extraction model by using only one palatal rugae; The first right palatal rugae (FRPR). The identification sequence is a result of the concatenation of both shape and measurements for the FRPR.    Results: Palatal Rugae Identification Extraction Model (PRIEM) facilitated by two main inputs. Shape analysis and measurement analysis. The shape analysis investigates the incisive papilla as a landmark as will as a classification for the palatal rugae shapes. Moreover, the first right palatal rugae is conducted to be the only one used to extract the identification rather than going through the whole palate. The measurement analysis conducted the middle point of the incisive papilla to use it as a landmark position for other measurements. A zero matches were found in this study indicating that the FRPR pattern is unique and applicable to use as a biometrics based identification.    Conclusion: The study estimated the uniqueness of the FRPR pattern by three ways: uniqueness of PR as a biometrics based identification, the uniqueness of FRPR-shape pattern, and the accuracy of palatal pattern measurement in 3D. The use of FRPR is simplify the way of extracting the palatal rugae identification.
Additional file 2: of Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages
Creators: name: Tanaka, Akane
name: To, Joyce
name: OâBrien, Bronwyn
name: Donnelly, Sheila
name: Lund, Maria
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S3. Assessment of RNA quality. Spectrophotometry analysis of the quality of RNA used in all qRT-PCRs. (DOCX 17 kb)
Trichomyia crinita Araujo & Bravo, sp. nov.
Creators: name: Araújo, Maíra Xavier
name: Bravo, Freddy
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Trichomyia
Trichomyia crinita

description: Trichomyia crinita Araújo & Bravo sp. nov.
(Figs. 24A–G)
Diagnosis. Gonocoxite with two pairs of elongated expansions; arm of gonocoxite with an expansion spur-shaped with sclerotized apex and with elongated bristles; one pair of filiform projections in the aedeagal complex; ejaculatory apodeme short, 1.2 times the length of gonostylus; cercus with two rod-like bristles.
Description. Male. Head subcircular in frontal view. Antenna with 13 flagellomeres; scape and pedicel subspherical; flagellomeres pyriform and eccentric (Fig. 24A); ascoids 1.4 times longer than the flagellomere; 13th flagellomere subcylindrical with terminal apiculus separated by suture (Fig. 24B). Palpus three segmented; first segment with sensilla in depressed pit on medial surface; palpus formula 1.0:0.5:0.7 (Fig. 24E). Wing. R4+5 with base unsclerotized; r-m unsclerotized and m-cu absent (Fig. 24D). Male terminalia: Hypandrium and gonocoxites fused with two pairs of elongated expansions, one medial plate-like and other basal and tubular. Arm of gonocoxite with an expansion spur-shaped with sclerotized apex and with elongated bristles. (Figs. 24C, 24G). Gonostylus digitiform, slightly sclerotized, articulated ventrally to gonocoxite, bare, curved, with rounded tip. Presence of one pair of filiform projections in the aedeagal complex. Aedeagus with pointed apex (Fig. 24G). Ejaculatory apodeme short, 1.2 times the length of gonostylus. Epandrium subcircular. Cercus with an apical expansion with two rod-like bristles. Hypoproct with apical micropilosity (Fig. 24F).
Female. Unknown.
Material examined. Brazil, Amazonas, Manacapuru, 27.XI.2001, holotype ♂, without name of collector (MZFS).
Etymology. From Latim, crinita = comet, refers to the shape of arm of gonocoxite.
Distribution. Brazil—Amazonas.
description: Published as part of Araújo, Maíra Xavier & Bravo, Freddy, 2016, Description of fourty four new species, taxonomic notes and identification key to Neotropical Trichomyia Haliday in Curtis (Diptera: Psychodidae, Trichomyiinae), pp. 1-76 in Zootaxa 4130 (1) on page 44, DOI: 10.11646/zootaxa.4130.1.1, http://zenodo.org/record/262717
Additional file 3: of Alignment-free sequence comparison: benefits, applications, and tools
Creators: name: Zielezinski, Andrzej
name: Vinga, Susana
name: Almeida, Jonas
name: Karlowski, Wojciech
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary methods. (DOCX 37 kb)
Socioeconomics status and hospitalization characteristics in the United States
Creators: name: Jumbo, Adiebonye E.
Publisher: name: No Publisher Supplied
Year: 2016

description: For several decades, social disparities in access to health care remain a major debate in the U.S. health care system. Despite growing attention to health inequalities, different social classes, especially, minority or ethnic groups, and those without health insurance coverage continue to face challenges to health care. To date, due to the complexities of Socioeconomic Status (SES), it is unclear how SES impacts health and income inequality.  The purpose of this dissertation was to examine the association of SES and median household income groups with hospitalization outcomes in the United States from 2008 to 2010. To examine the generalizability of this phenomenon, a retrospective study was used to analyze the pattern of care for hospitalized patients between the ages of 18 and 89, using the National Inpatient Sample (NIS) data of the Healthcare Cost and Utilization Project (HCUP). The study sample consisted of 500,000 admission records and stratified and regression analysis were computed to determine the differences by age, sex, race or ethnicity, income, location, diagnoses, procedures, length of stay, payer, and costs affecting each of the defined income categories. Total hospital costs were examined within the categorical income groups by residential zip code and top 10 diagnoses and procedures showed that high medical costs is an issue across SES groups. Descriptive and inferential statistical analyses were performed. Mean, median, standard deviation, and range were used to calculate continuous variables while frequency counts and chi-square tests of association were conducted to evaluate differences in proportion for categorical variables. Linear regression modeling and multivariable modeling techniques were undertaken to test the hypotheses. Measurement and structural models were tested through structural equation modeling statistical techniques using SPSS version 22.0. When compared the SES differences among the four categorical income groups, the results show that people at the lower quintile were more likely to face higher hospitalization due to their income. Each year, many programs are designed to reduce hospital admissions, but regardless of these efforts the rates of hospitalization continue to increase in U.S population. This study recommended scientific approach in understanding of the role SES and income as they impact health disparities, which will potentially help health providers, researchers, policy makers, and public health planners to design individualized and community-wide programs and policies related to income inequality and hospitalization for high risk populations.
Clinical value of BRE-AS1 in myocardial infarction and its role in myocardial infarction-induced cardiac muscle cell apoptosis
Creators: name: Gao, Zhen
name: Zhu, Hezhong
name: Chen, Jieqiong
name: Liu, Wei
name: Huo, Jiangtao
name: He, Chaoyong
name: Chen, Jiajuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Objectives. The aim of this study was to investigate the expression of long non-coding RNA (lncRNA) brain and reproductive organ-expressed protein (BRE) antisense RNA 1 (BRE-AS1) in patients with acute myocardial infarction (AMI) and its effect on ischemia/reperfusion (I/R)-induced oxidative stress and apoptosis of cardiomyocytes. Methods. Serum BRE-AS1 levels in patients with AMI was detected using quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic and prognostic values of BRE-AS1 were evaluated. H9c2 cells were treated with hypoxia/reoxygenation to establish an in vitro myocardial infarction cell model. The levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Levels of lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined by commercial kits. Cell counting kit-8 (CCK-8) and flow cytometry were used to evaluate the cell viability and cell apoptosis. Results. The expression of BRE-AS1 in serum of patients with AMI is upregulated, which shows the clinical diagnostic value for AMI. In the I/R injury cell model, the knockout of BRE-AS1 can significantly alleviate the increase in TNF-α, IL-1β, and IL-6 levels, inhibit the production of LDH and MDA, increase the activities of SOD and GSH-Px, promote the cell viability and suppress cell apoptosis. Conclusions. Abnormally elevated BRE-AS1 has a high diagnostic value for AMI as well as a prognostic value for major adverse cardiovascular events (MACEs). The elevation of BRE-AS1 promoted oxidative stress injury and cell apoptosis in vitro.
Additional file 1: of Effectiveness of two web-based cognitive bias modification interventions targeting approach and attentional bias in gambling problems: study protocol for a pilot randomised controlled trial
Creators: name: Boffo, Marilisa
name: Willemen, Ronny
name: Pronk, Thomas
name: Wiers, Reinout
name: Dom, Geert
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: SPIRIT 2013 checklist. (DOC 122Â kb)
Trichomyia danieli Bravo
Creators: name: Araújo, Maíra Xavier
name: Bravo, Freddy
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Trichomyia
Trichomyia danieli

description: Trichomyia danieli Bravo
Trichomyia danieli Bravo, 2001c: 125 –126, figs. 18–23.
Comments. Males of Trichomyia danieli are recognized by two arm of gonocoxite, both with elongated apical bristles; hypoproct with pointed apex and ejaculatory apodeme long, 1.5 times the length of gonocoxite. Material examined. Brazil, Bahia: Serra da Jibóia, holotype ♂, 16.III.2001, I. Castro & I. Soares leg. (MZFS). Distribution. Brazil—Bahia.
description: Published as part of Araújo, Maíra Xavier & Bravo, Freddy, 2016, Description of fourty four new species, taxonomic notes and identification key to Neotropical Trichomyia Haliday in Curtis (Diptera: Psychodidae, Trichomyiinae), pp. 1-76 in Zootaxa 4130 (1) on pages 44-45, DOI: 10.11646/zootaxa.4130.1.1, http://zenodo.org/record/262717
Trichomyia elongata Araujo & Bravo, sp. nov.
Creators: name: Araújo, Maíra Xavier
name: Bravo, Freddy
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Trichomyia
Trichomyia elongata

description: Trichomyia elongata Araújo & Bravo sp. nov.
(Figs. 25A–I)
Diagnosis. R4+5 complete at base; r-m present; arm of gonocoxite directed to midline, apically bifurcated and with a group of elongated bristles in the center; one pair of lanciform projections in the aedeagal complex; aedeagus ending after the apex of projections in the aedeagal complex; ejaculatory apodeme short, 0.5 times the length of medial expansion of gonocoxite; cercus with apical projection with two setae.
Description. Male. Head subcircular in frontal view. Antenna with 13 flagellomeres; scape about the same length as the subspherical pedicel; flagellomeres pyriform, eccentric (Figs 25A, 25B); basal ascoids 1.7 times the length of flagellomere (Fig. 25D); 13th flagellomere subcylindrical with terminal apiculus separated by a suture (Fig. 25B). Palpus with three segments; 1st segment with sensilla in depressed pit on medial surface; palpus formula 1.0:0.9:0.9 (Fig. 25C). Wing. R4+5 complete at base; r-m present; m-cu absent (Fig. 25E). Male terminalia: Hypandrium fused with gonocoxites with a pair of medial lanciform expansion. Gonocoxites with posterior arm directed to midline, apically bifurcate and with a group of elongated bristles in the center. Gonostylus articulated to gonocoxite at the middle, bare, with apex directed upward (Fig. 25G). Projections in the aedeagal complex, one pair, lanciform. Aedeagus ending after the apex of projections in the aedeagal complex (Fig. 25H). Ejaculatory apodeme short, 0.5 times the length of medial expansion of gonocoxite. Epandrium pilose, posteriorly wider than anteriorly. Cercus pilose, piriform, with apical elongated projection with two setae (Figs. 25G, 25I). Epiproct shorter than hypoproct, both with apical micropilosity (Fig. 25G).
Female. Unknown.
Material examined. Brazil, Bahia, Cachoeira, Fazenda Villa Rial, holotype ♂, 24.V.2004, F. Bravo leg. (MZFS); 1 paratype ♂, same locality, date and collector than holotype (MZFS).
Etymology. The epithet elongata refers to the elongated apex of cercus. Distribution. Brazil—Bahia.
Remarks. The paratype has M1 and M2 veins fused near the apex (Fig. 25F).
description: Published as part of Araújo, Maíra Xavier & Bravo, Freddy, 2016, Description of fourty four new species, taxonomic notes and identification key to Neotropical Trichomyia Haliday in Curtis (Diptera: Psychodidae, Trichomyiinae), pp. 1-76 in Zootaxa 4130 (1) on pages 45-47, DOI: 10.11646/zootaxa.4130.1.1, http://zenodo.org/record/262717
Additional file 3: of Alignment-free sequence comparison: benefits, applications, and tools
Creators: name: Zielezinski, Andrzej
name: Vinga, Susana
name: Almeida, Jonas
name: Karlowski, Wojciech
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary methods. (DOCX 37 kb)
Lyttini Bologna & Amore & Pitzalis 2018
Creators: name: Bologna, Marco A.
name: Amore, Valentina
name: Pitzalis, Monica
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Meloidae

description: Tribe Lyttini
According to morphological (Bologna & Pinto 2001) and a preliminar molecular study (Bologna et al. 2008c), Lyttini appear to be a polyphyletic group. Additional molecular studies actually support the monophyly of the tribe with the inclusion of some genera referred to other tribes (Bologna et al. unpublished). In the present catalogue, we consider in this tribe the genera previously referred to Lyttini by Bologna (1991) and by Bologna & Pinto (2002), with the addition of Cyaneolytta.
description: Published as part of Bologna, Marco A., Amore, Valentina & Pitzalis, Monica, 2018, Meloidae of Namibia (Coleoptera): taxonomy and faunistics with biogeographic and ecological notes, pp. 1-141 in Zootaxa 4373 (1) on page 20, DOI: 10.11646/zootaxa.4373.1.1, http://zenodo.org/record/1151722
Development of a computational tool for forensic DNA analysis
Creators: name: Arnold, Anurag
Publisher: name: No Publisher Supplied
Year: 2016

description: Forensic DNA analysis consists of a DNA profiling process by a method called as STR Analysis, short for Short Tandem Repeats. By using the statistics it provides, various probabilistic approaches are implemented in a software package to find out DNA profile matches and individual identifications. This study has contributed in the design, development and integration of an easy to use and interactive software application to find the number of contributors in a DNA sample and to find a match against it with another person’s DNA. This research specifically deals with the (1) design of an algorithm for filtering unfiltered DNA profile samples to remove bleed-through peaks; (2) design of an interactive interface for MatchIt, where a DNA sample of a person of interest is tested against a DNA sample to find a match; and (3) data modeling, design and integration of a database for the software.
Afrolytta Kaszab 1959
Creators: name: Bologna, Marco A.
name: Amore, Valentina
name: Pitzalis, Monica
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Meloidae
Afrolytta

description: Genus Afrolytta Kaszab, 1959
The genus is recorded for the first time from Namibia and it results endemic to both Namibian and South African Namaqualand. Afrolytta needs to be revised because Kaszab (1959) asssigned to it only three species (A. amoena, A. carneola, and A. mashuna). A new species from South African Namaqualand is described below, while mashuna (Péringuey, 1899), actually belongs to the eleticine genus Morphozonitis Pic, 1922 (Bologna 2009).
description: Published as part of Bologna, Marco A., Amore, Valentina & Pitzalis, Monica, 2018, Meloidae of Namibia (Coleoptera): taxonomy and faunistics with biogeographic and ecological notes, pp. 1-141 in Zootaxa 4373 (1) on page 20, DOI: 10.11646/zootaxa.4373.1.1, http://zenodo.org/record/1151722
Additional file 2: Figure S1. of Development and evaluation of a speech-generating AAC mobile app for minimally verbal children with autism spectrum disorder in Mainland China
Creators: name: Sainan An
name: Xiaoping Feng
name: Dai, Yue
name: Hongli Bo
name: Xiuqing Wang
name: Li, Mu
name: Woo, John
name: Xingmei Liang
name: Guo, Cheng
name: Liu, Charles
name: Liping Wei
Publisher: name: Figshare
Year: 2017
Subjects: subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Accuracy rates of each child for the phases in which the child was trained and achieved three consecutive unprompted successful responses. (PDF 951Â kb)
Additional file 1: Figure S1. of Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers
Creators: name: Baldassarre, Tomas
name: Truesdell, Peter
name: Craig, Andrew
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Endo II expression and association with risk of metastasis and chemotherapy response in HER2+ breast cancers. Figure S2. Endo II silencing in SK-BR-3 cells. Figure S3. Endo II overexpression leads to reduced surface HER2. Figure S4. Endo II promotes EGF-induced Akt activation in SK-BR-3 cells. Figure S5. Endo II promotes HER2 internalization in HCC1954 cells. Figure S6. Endo II promotes SK-BR-3 cell motility. Figure S7. Endo II silencing has no overt effects on HER2+ tumor growth. Figure S8. Endo II promotes HER2 internalization and downregulation following trastuzumab treatment of HCC1954 cells. Figure S9. Endo II promotes cytoxicity upon treatment with trastuzumab, but not with lapatinib, in HER2+ cancer cells. Figure S10. Endo II overexpression results in increased sensitivity to T-DM1. (DOCX 1965 kb)
Single center outcomes after temporary mechanical circulatory assist device prior to Heartmate 3 implantation – a retrospective cohort study
Creators: name: Iversen, Imran Jamal
name: Gustafsson, Finn
name: Rossing, Kasper
name: Møller-Sørensen, Peter Hasse
name: Olsen, Peter Skov
name: Møller, Christian Holdflod
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer

description: Objectives. Temporary mechanical circulatory support (TMCS) has become a component in the therapeutic strategy for treatment of cardiogenic shock as a bridge-to-decision. TMCS can facilitate recovery of cardiopulmonary function, end-organ function, and potentially reduce the surgical risk of left ventricular assist device (LVAD) implantation. Despite the improvements of hemodynamics and end-organ function, post-LVAD operative morbidity might be increased in these high-risk patients. The aim of the study was to compare outcomes after Heartmate 3 (HM3) implantation in patients with and without TMCS prior to HM3 implant. Methods. In this retrospective cohort study of all HM3 patients in the period between November 2015 and October 2021, patients with and without prior TMCS were compared. Patients’ demographics, baseline clinical characteristics, laboratory tests, intraoperative variables, postoperative outcomes, and adverse events were collected from patient records. Results. The TMCS group showed an improvement in hemodynamics prior to LVAD implantation. Median TMCS duration was 19.5 (14–26) days. However, the TMCS group were more coagulopathic, had more wound infections, neurological complications, and more patients were on dialysis compared with patient without TMCS prior to HM3 implantation. Survival four years after HM3 implantation was 80 and 82% in the TMCS (N = 22) and non-TMCS group (N = 41), respectively. Conclusion. Patients on TMCS had an acceptable short and long-term survival and comparable to patients receiving HM3 without prior TMCS. However, they had a more complicated postoperative course.
Interpretations of normal
Creators: name: Brown, Leigh-Ann Leinhauser
Publisher: name: No Publisher Supplied
Year: 2016

description: This qualitative work provides insight into the lives of children with diverse abilities and their families as they negotiate social mandates of family life. Through interviews of various family members, from siblings to grandparents, I have found families attempting to interpret perceived prescriptions of normality with a family member stigmatized by medical, cognitive, and/or behavioral deviations. Through this work, I reveal that although the term normal eludes definition, it is constructed and re-constructed as each family member makes sense of specific life experiences. The families depict what they believe to be “normal” family life as they understand it from past experiences and their surrounding culture. However, family members continue to play with the term in defining experiences that fall outside of or transcend what they believe to be typical interactions. As the families in this study define themselves as a unit, “normal” appears to be a baseline by which they interpret their lived experiences of family life and childhood resulting in a creation of a new normal or belief in their “beyond normal” characteristics. The unintended consequences of adhering to mythical constructions of family life, creating a new normal, and beyond normal perceptions are also explored. Analyzing the ways in which families portray their daily interactions will contribute to the fields of childhood studies and special education by providing a nuanced view of childhood, family life, and parental involvement.
Trichomyia grossa Araujo & Bravo, sp. nov.
Creators: name: Araújo, Maíra Xavier
name: Bravo, Freddy
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Psychodidae
Trichomyia
Trichomyia grossa

description: Trichomyia grossa Araújo & Bravo sp. nov.
(Figs. 26A–F)
Diagnosis. R4+5 complete at base; lanceolate expansion on gonocoxite; two pairs of projections in the aedeagal complex, sclerotized medial and shorter than lateral; ejaculatory apodeme 1.5 the length of lateral projection of aedeagal complex.
Description. Male. Head subcircular in frontal view. Antenna incomplete in the studied specimens; scape shorter than pedicel; pedicel subspherical; basal flagellomeres pyriform and eccentric; ascoids 1.3 times the length of flagellomere (Fig. 26A). Palpus with three segments; 1st segment with sensilla in depressed pit on medial surface; palpus formula 1.0:0.5:0.6 (Fig. 26B). Wing. R4+5 complete at base; r-m and m-cu absent (Fig. 26C). Male terminalia: Hypandrium fused with gonocoxites with lanceolate ventral expansion (Fig. 26F). Gonocoxites with posterior arm subrectangular in lateral view with a row of basal bristles (Figs. 26D, 26F). Gonostylus articulated to gonocoxite basally, bare, with apex directed dowward. Projections in the aedeagal complex, two pairs, sclerotized medial and smaller than lateral. Aedeagus ending after the apex of medial projection of aedeagal complex. Ejaculatory apodeme 1.5 the length of lateral projection of aedeagal complex. Epandrium pilose, subrectangular (Fig. 26E). Cercus pilose (Figs. 26D, 26E), subelliptical in lateral view, larger basally than apically. Epiproct shorter than hypoproct, both with apical micropilosity (Fig. 26D).
Female. Unknown.
Material examined. Brazil, Bahia, Porto Seguro, Estação Vera Cruz, holotype ♂, 05.XII.2002, F. Bravo leg. (MZFS).
Etymology. The epithet grossa refers to the shape of arm of gonocoxite.
Distribution. Brazil—Bahia.
description: Published as part of Araújo, Maíra Xavier & Bravo, Freddy, 2016, Description of fourty four new species, taxonomic notes and identification key to Neotropical Trichomyia Haliday in Curtis (Diptera: Psychodidae, Trichomyiinae), pp. 1-76 in Zootaxa 4130 (1) on pages 47-48, DOI: 10.11646/zootaxa.4130.1.1, http://zenodo.org/record/262717
Associations between hyperactive-impulsive and inattentive symptoms of ADHD and self-report and behavioral measures of impulsivity
Creators: name: Ducey, Avery Bramell
Publisher: name: No Publisher Supplied
Year: 2016

description: Those with Attention Deficit-Hyperactivity Disorder (ADHD) are diagnosed with one of three subtypes,   Inattentive, Hyperactive/Impulsive, or the Combined subtype. Recent research has concluded that impulsive behavior is the product of multiple psychological traits instead of one impulsivity construct (Whiteside & Lynam, 2001). The strength of these different impulsivity sub-dimensions affect which type(s) of impulsive behavior an individual exhibits. This project examined the relationship between scores on self-report and behavioral measures of impulsivity constructs and scores on a measure of ADHD subtype symptoms. The secondary data used in this proposal was collected from 138 undergraduate students at Rutgers University – Camden. Participants were administered several behavioral measures of impulsivity (the Go-Stop and Immediate Memory Task), the Urgency   Premeditation Perseverance Sensation Seeking Impulsive Behavior Subscales with the Positive Urgency Measure (UPPS-P) (a questionnaire measuring different impulsivity dimensions), and the Adult ADHD Self-Report Scale (ASRS). Analyses were conducted to examine the associations between ADHD subtypes and impulsivity sub dimensions. Throughout the tests conducted both subtypes were strongly associated with self-report measures of impulsivity and not associated with behavioral measures of impulsivity. These analyses revealed that generally symptoms of ADHD subtypes are not differently associated with measures of impulsivity. The one exception was the Inattentive subtype of ADHD’s unique associations with a self-reported lack of Perseverance.
Additional file 1: of Tissue-aware RNA-Seq processing and normalization for heterogeneous and sparse data
Creators: name: Paulson, Joseph
name: Cho-Yi Chen
name: Lopes-Ramos, Camila
name: Kuijjer, Marieke
name: Platig, John
name: Abhijeet Sonawane
name: Fagny, Maud
name: Glass, Kimberly
name: Quackenbush, John
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material for Tissue-aware RNA-Seq processing and normalization for heterogeneous and sparse data. (DOCX 37 kb)
Occurrence of Legionella in reclaimed water distribution systems
Creators: name: Johnson, William Joseph
Publisher: name: No Publisher Supplied
Year: 2016

description: Legionella bacteria are an emerging pathogen found in natural and engineered water systems.  Infection occurs when infected water becomes aerosolized and is breathed into the lungs.  Reclaimed water is commonly used in scenarios where the water becomes aerosolized, such as for spray irrigation and in industrial cooling towers.   It is important to measure the risk of Legionella infection from these waters but, their prevalence in reclaimed water distribution systems has not been adequately documented.  To determine the occurrence and concentration of Legionella in reclaimed water, a monitoring study was conducted at six water utilities.  The systems, located in California, Florida, Texas and Arizona, represented different treatment processes, storage conditions and distribution system sizes.  The treatment systems produced water varying in organic carbon and other nutrients, which allowed the examination of each water quality parameter in relation to the occurrence of Legionella and their associated protozoa hosts.  From each water utility, samples were taken from the plant effluent, storage reservoir and three points within the distribution system.     Legionella was found frequently throughout the storage and distribution systems, though their concentrations were generally low.  Sixteen species of Legionella were identified using culture plating and molecular methods, with L. pneumophila being the species most frequently detected and the only species found in all six reclaimed water utilities.  Disinfectants were effective at controlling Legionella growth when present, but were rapidly consumed in the distribution systems.  Chlorine residuals of at least 1 mg/L (total chlorine) and 0.2 mg/L (free chlorine) reduced Legionella concentrations over 80%.  High levels of assimilable organic carbon (AOC), total organic carbon (TOC) and ammonia had a clear impact on the occurrence of Legionella.  Over 70% more Legionella were detected in locations where AOC was above 1000 µg/L and/or TOC was above 10 mg/L.  In samples where ammonia was less than 2 mg/L, the concentration of viable Legionella was 90% lower than in samples where ammonia was above 2 mg/L.  The reclaimed system with the lowest occurrence of Legionella also had the lowest average concentrations of AOC, TOC and ammonia.  The two systems with the most Legionella also had the highest average concentrations of AOC, TOC and ammonia.     Mesophilic and thermophilic protozoa were regularly detected throughout the reclaimed water systems and their numbers increased as the water aged in the distribution system.
Additional file 2: Figure S1. of Tissue-aware RNA-Seq processing and normalization for heterogeneous and sparse data
Creators: name: Paulson, Joseph
name: Cho-Yi Chen
name: Lopes-Ramos, Camila
name: Kuijjer, Marieke
name: Platig, John
name: Abhijeet Sonawane
name: Fagny, Maud
name: Glass, Kimberly
name: Quackenbush, John
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: PCoA analysis of multiple tissues on Y-chromosomal genes can highlight poor sex annotation, related to Fig.Â 1 and misannotation section. Scatterplots of the first and second principal components from principal component analysis on all major tissue regions. We plotted data from 13 tissue regions from the GTEx consortium, coloring the annotated sex of each sample. Enlarged is sample GTEX-11ILO that clusters with male samples in every tissue despite being annotated as being from a female; we later learned that this research subject was genetically male. (PDF 240 kb)
Electrocardiographic abnormalities and NT-proBNP levels at long-term follow-up of patients with dyspnea after pulmonary embolism
Creators: name: Nilsson, Lars T.
name: Andersson, Therese
name: Carlberg, Bo
name: Johansson, Lars Å.
name: Söderberg, Stefan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health
subject: Hematology

description: Electrocardiogram (ECG) and measurement of plasma brain natriuretic peptides (BNP) are established markers of right ventricular dysfunction (RVD) in the setting of acute pulmonary embolism (PE) but their value at long-term follow-up is largely unknown. The purpose of this prospective study was to determine the prevalence of ECG abnormalities, describe levels of N-terminal proBNP (NT-proBNP), and establish their association with dyspnea at long-term follow-up after PE. All Swedish patients diagnosed with acute PE in 2005 (n = 5793) were identified through the Swedish National Patient Registry. Surviving patients in 2007 (n = 3510) were invited to participate. Of these, 2105 subjects responded to a questionnaire about dyspnea and comorbidities. Subjects with dyspnea or risk factors for development of chronic thromboembolic pulmonary hypertension were included in the study in a secondary step, which involved collection of blood samples and ECG registration. Altogether 49.3% had a completely normal ECG. The remaining participants had a variety of abnormalities, 7.2% had atrial fibrillation/flutter (AF). ECG with any sign of RVD was found in 7.2% of subjects. Right bundle branch block was the most common RVD sign with a prevalence of 6.4%. An abnormal ECG was associated with dyspnea. AF was associated with dyspnea, whereas ECG signs of RVD were not. 61.2% of subjects had NT-proBNP levels above clinical cut-off (>125 ng/L). The degree of dyspnea did not associate independently with NT-proBNP levels. We conclude that the value of ECG and NT-proBNP in long term follow-up after PE lies mostly in differential diagnostics.
Luxurious
Creators: name: McCourt, Erin
Publisher: name: No Publisher Supplied
Year: 2016

description: This collection of 7 loosely interconnecting stories revolves around a Philadelphia bar named The Luxurious, or the Lux, and its regulars and those connected to the regulars between the years 1985 and 2012. The South Philadelphia Neighborhood is changing and this bar is at the center of its controversial gentrification, and so the characters include both the new Millennials and the old timers who meet at this watering hole.    The lead character is Declan, bar owner, who must make a decision to either keep the bar (which is paid off), or sell it as part of his divorce settlement. Additionally, there is Shaiful, an Indian-American colonial impersonator, Sandy, a widow, Rick, a drag queen, Bo, a new transplant from Chicago, and several other characters whose lives loosely interconnect in the style of novels such as Olive Kittredge or A Visit from the Goon Squad. These are the first 7 stories of what will eventually be a longer collection.
Values of three-dimensional speckle tracking imaging for the diagnosis of coronary artery disease
Creators: name: Zhao, Dexia
name: Zhou, Zhenfang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Background: Coronary artery disease (CAD) is a top life-threatening disease and early and sensitive detection of CAD remains a challenge. This study aimed to assess the value of three-dimensional speckle tracking imaging (3D-STI) in diagnosing CAD patients and investigate the parameters of 3D-STI associated with disease severity. Methods: A total of 260 suspected CAD patients who met the study criteria underwent coronary angiography within one week after the ultrasound examination. Based on the examination results, 142 patients were confirmed to have CAD (CAD group), while 118 patients were classified as non-CAD (NCAD group). Age, gender, family history, smoking status, diabetes, hypertension, dyslipidemia, electrocardiogram, BMI, heart rate, and left ventricular ejection fraction were compared between the two groups. Additionally, 3D-STI parameters including left ventricular global radial strain (GRS), left ventricular global longitudinal strain (GLS), left ventricular global area strain (GAS), and left ventricular global circumferential strain (GCS) were analyzed. Results: No significant differences were found between the CAD and NCAD groups in terms of demographics, smoking history, physiological measurements, and common comorbidities such as diabetes mellitus and dyslipidemia. However, when comparing the 3D-STI parameters, all four parameters, including GLS, GRS, GCS, and GAS, were significantly different in the CAD group compared to the NCAD group. The results suggest that 3D-STI parameters have diagnostic value for CAD, and their changes are associated with CAD severity. Conclusions: Combined detection of these parameters enhances diagnostic accuracy compared to individual detection.
Additional file 1: Figure S1. of Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers
Creators: name: Baldassarre, Tomas
name: Truesdell, Peter
name: Craig, Andrew
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Endo II expression and association with risk of metastasis and chemotherapy response in HER2+ breast cancers. Figure S2. Endo II silencing in SK-BR-3 cells. Figure S3. Endo II overexpression leads to reduced surface HER2. Figure S4. Endo II promotes EGF-induced Akt activation in SK-BR-3 cells. Figure S5. Endo II promotes HER2 internalization in HCC1954 cells. Figure S6. Endo II promotes SK-BR-3 cell motility. Figure S7. Endo II silencing has no overt effects on HER2+ tumor growth. Figure S8. Endo II promotes HER2 internalization and downregulation following trastuzumab treatment of HCC1954 cells. Figure S9. Endo II promotes cytoxicity upon treatment with trastuzumab, but not with lapatinib, in HER2+ cancer cells. Figure S10. Endo II overexpression results in increased sensitivity to T-DM1. (DOCX 1965 kb)