Bibliometric analysis of research on the utilization of nanotechnology in diabetes mellitus and its complications
Creators: name: Zhang, Jiexin
name: He, Meng
name: Gao, Guanbin
name: Sun, Taolei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: <b>Aim:</b> To identify hotspots in this field and provide insights into future research directions. <b>Methods:</b> Publications were retrieved from the Web of Science Core Collection database. R Bibliometrix software, VOSviewer and CiteSpace were used to perform the bibliometric and visualization analyses. <b>Results:</b> The analysis comprised 468 publications from 58 countries, with the United States, China and India being the leading contributors. ‘Gene therapy’, ‘nanoparticles’ and ‘insulin therapy’ are the primary focuses. ‘Green synthesis’, ‘cytotoxicity’, ‘bioavailability’ and ‘diabetic foot ulcers’ have gained prominence, signifying high-intensity areas of interest expected to persist as favored research topics in the future. <b>Conclusion:</b> This study delves into recent frontiers and topical research directions and provides valuable references for further research in this field. Diabetes mellitus and its complications are substantial global public health concerns given their elevated mortality rates and economic impact. As an emerging technology of the 21st century, nanotechnology plays a crucial role in the diagnosis, monitoring and treatment of diabetes and its complications, offering advantages such as targeting specificity, excellent biocompatibility and high bioavailability. Bibliometrics can analyze the distribution and correlation of authors/countries/institutions in the published literature of a particular research field. It can also objectively and reliably analyze research hotspots, evolutionary trends and anticipate future developments in a given field. This marks the inaugural bibliometric study delving into the application of nanomedicines in diabetes mellitus and its complications from 2001 to 2023. Our results found that nanotechnology research on diabetes and its complications began in 2001 and is still in a continuous development phase. The United States, China and India being the leading contributors in this field. Zhejiang University has the most research in this area, and ACS Nano is the most popular journal. Zhang Y and Wang X are the most valuable authors. ‘Gene therapy’, ‘nanoparticles’ and ‘insulin therapy’ are the primary focus areas in this field. ‘Green synthesis’, ‘cytotoxicity’, ‘bioavailability’ and ‘diabetic foot ulcers' will be the promising interests in the future. This study supplements the research data in this field, offering new perspectives and references for scholars focusing on diabetes and its complications. This study includes an examination of the primary contributing countries, institutions, authors and the current status of research in this area to track the characteristics of developments and future trends. During the past 23 years, there has been a discernible upward trajectory in the number of studies investigating the application of nanotechnology in diabetes mellitus and its complications. Prominent contributors to this research landscape include the United States, China and India, with Zhejiang University in China emerging as a leading institution in terms of the quantity of studies conducted. A noteworthy concentration of research articles is found in <i>ACS Nano</i>, a journal that not only publishes prolifically in this domain but also commands high citations, establishing itself as a reputable and widely acknowledged source. Zhang Y and Wang X stand out, boasting the highest H-index, a substantial number of published articles and citations. Research on “gene therapy”, “nanoparticles” and “insulin therapy” are the primary focus areas in this field. Research on the mechanisms of diabetes and its complications focuses on “oxidative stress” and “inflammation”. In the future, topics such as “green synthesis”, “cytotoxicity”, “bioavailability” and “diabetic foot ulcers” are expected to become research hotspots in this field. Being the first bibliometric study to comprehensively summarize and analyze the application of nanotechnology in diabetes mellitus and its complications, this research delves into the recent frontiers and topical directions of research and will provide valuable references for further research in this field.