cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification and quantification of surface wax compounds covering aerial organs of selected plant species
Creators: name: Racovita, Radu C.
Publisher: name: University of British Columbia
Year: 2017

description: The cuticle is an external barrier of aerial plant organs that prevents desiccation. It is composed of hydrophobic waxes, i.e. complex mixtures of very-long-chain aliphatics, alicyclics and aromatics, lying on top of (epicuticular) and in between (intracuticular) a polyester matrix known as cutin. Wax compositions vary greatly between plant species, organs and tissues, both qualitatively and quantitatively. This thesis describes the identification and quantification of cuticular waxes of three plant species, including structure elucidation of novel compounds, chain length profiling, and wax compound distributions between intracuticular and epicuticular compartments for the first two species. Leaves of Aloe arborescens were found covered with 15 μg/cm² wax on the adaxial side and 36 μg/cm² on the abaxial side, with 3:2 and 1:1 ratios between epicuticular and intracuticular wax layers on each side, respectively. Along with ubiquitous wax compounds, three homologous series were identified as novel 3-hydroxy fatty acids (predominantly C₂₈), their methyl esters (predominantly C₂₈), and 2-alkanols (predominantly C₃₁), and their biosynthetic pathways were hypothesized based on structural similarities and homolog distributions. The adaxial side of young and old Phyllostachys aurea leaves was found covered with 1.7 to 1.9 μg/cm² each of epi- and intracuticular waxes. In addition to typical aliphatics and alicyclics, novel primary amides were identified, with their chain length profile peaking at C₃₀, and found exclusively in the epicuticular waxes, hence near the true plant surface. Flag leaves and peduncles of Triticum aestivum cv. Bethlehem were found covered with 16 and 49 μg/cm² wax, respectively, dominated by 1-alkanols in the case of the former and β-diketones and hydroxy-β-diketones for the latter. Along with previously reported wax classes, numerous new classes were identified as homologous series: 2-alkanol esters, benzyl esters, phenethyl esters, p-hydroxyphenethyl esters, secondary alcohols, primary/secondary diols and their esters, hydroxy- and oxo-2-alkanol esters, 4-alkylbutan-4-olides, internally methyl-branched alkanes, and 2,4-ketols. Other new compounds were found as single homologs: C₃₃ 2,4-diketone, C₃₁ mid-chain β-ketols, C₃₀ mid-chain α-ketols and α-diketone, as well as C₃₁ mid-chain ketones. Biosynthetic pathways are proposed in the thesis for the new compounds, based on common structural features and matching chain length patterns between related compound classes.
Indirect discrimination: Insights into the impacts of the ‘Prevent duty’ on Muslim minority communities in the UK
Creators: name: Cantlow, Rachel
Publisher: name: Eurac Research
Year: 2025

description: The UK has a diverse demographic, encompassing multiple ethnic, racial, and religious groups, resulting in a vibrant, multicultural society. Religious and ethnic minorities include, but are not limited to, Muslims, Hindus, Sikhs, Jews, Buddhists, Asian British, Black British, Roma, Irish communities, and [many more](https://minorityrights.org/country/united-kingdom/).
Tool Support for Finding and Preventing Faults in Rule Bases
Creators: name: Zacharias, Valentin
Publisher: name: Karlsruhe
Year: 2008
Subjects: Rule Based System
Verification and Validation
Debugging
Testing

description: This thesis analyzes challenges for the correct creation of rule bases. Based on experiences and data from three rule base development projects, dedicated experiments and a survey of developers, ten main problem areas are identified. Four approaches in the area of Testing, Debugging, Anomaly Detection and Visualization are proposed and evaluated as remedies for these problem areas.
Additional file 1 of Renal outcomes according to renal replacement therapy modality and treatment protocol in the ATN and RENAL trials
Creators: name: Naorungroj, Thummaporn
name: Neto, Ary Serpa
name: Wang, Amanda
name: Gallagher, Martin
name: Bellomo, Rinaldo
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Additional file 1. Supplementary Methods, Supplementary Tables 1-13 and Supplementary Figures 1-8.
Additional file 2 of De-implementation and substitution of clinical care processes: stakeholder perspectives on the transition to primary human papillomavirus (HPV) testing for cervical cancer screening
Creators: name: Hahn, Erin E.
name: Munoz-Plaza, Corrine
name: Altman, Danielle E.
name: Hsu, Chunyi
name: Cannizzaro, Nancy T.
name: Ngo-Metzger, Quyen
name: Wride, Patricia
name: Gould, Michael K.
name: Mittman, Brian S.
name: Hodeib, Melissa
name: Tewari, Krishnansu S.
name: Ajamian, Lena H.
name: Eskander, Ramez N.
name: Tewari, Devansu
name: Chao, Chun R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 2. Implementing Primary HPV Testing Patient Interview Guide.
Additional file 3 of De-implementation and substitution of clinical care processes: stakeholder perspectives on the transition to primary human papillomavirus (HPV) testing for cervical cancer screening
Creators: name: Hahn, Erin E.
name: Munoz-Plaza, Corrine
name: Altman, Danielle E.
name: Hsu, Chunyi
name: Cannizzaro, Nancy T.
name: Ngo-Metzger, Quyen
name: Wride, Patricia
name: Gould, Michael K.
name: Mittman, Brian S.
name: Hodeib, Melissa
name: Tewari, Krishnansu S.
name: Ajamian, Lena H.
name: Eskander, Ramez N.
name: Tewari, Devansu
name: Chao, Chun R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 3. Implementing Primary HPV Testing Physicians, Nurses, and Administrators Interview Guide.
Additional file 4 of De-implementation and substitution of clinical care processes: stakeholder perspectives on the transition to primary human papillomavirus (HPV) testing for cervical cancer screening
Creators: name: Hahn, Erin E.
name: Munoz-Plaza, Corrine
name: Altman, Danielle E.
name: Hsu, Chunyi
name: Cannizzaro, Nancy T.
name: Ngo-Metzger, Quyen
name: Wride, Patricia
name: Gould, Michael K.
name: Mittman, Brian S.
name: Hodeib, Melissa
name: Tewari, Krishnansu S.
name: Ajamian, Lena H.
name: Eskander, Ramez N.
name: Tewari, Devansu
name: Chao, Chun R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 4. List of Potential Barriers – Primary HPV Testing for Routine Cervical Cancer Screening.
Robust Shrinkage Estimation of High-dimensional Covariance Matrices
Creators: name: Chen, Yilun
name: Wiesel, Ami
name: Hero, Alfred O.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: We address high dimensional covariance estimation for elliptical distributed samples, which are also known as spherically invariant random vectors (SIRV) or compound-Gaussian processes. Specifically we consider shrinkage methods that are suitable for high dimensional problems with a small number of samples (large $p$ small $n$). We start from a classical robust covariance estimator [Tyler(1987)], which is distribution-free within the family of elliptical distribution but inapplicable when $n
Identification and characterization of a novel allosteric glutamate binding site on the GABA-A receptor
Creators: name: Wen, Ya
Publisher: name: University of British Columbia
Year: 2021

description: The A type γ-aminobutyric acid receptor (GABAAR) mediates major inhibition to counteract glutamate receptor-mediated excitation in the Central Nervous System (CNS). However, work in this dissertation identified a novel glutamate-binding site at the α+β- interface of the GABAAR. Activation of this glutamate binding site by glutamate and analogues can potentiate both the synaptic GABAAR-mediated phasic responses and the extrasynaptic GABAAR-mediated tonic inhibition. Using systematic mutagenesis analysis, we identified a conserved group of charged amino acid residues including α1K104, α1K155, α1E137 and β2E181, that form this glutamate binding site at the extracellular domain of the GABAAR. Spatial and electrostatic accessibility are both crucial for glutamate binding on this site. Furthermore, through in-silicon and electrophysiological screening, we identified that ampicillin, an antibiotic, and BRC640 as novel compounds that can target this newly identified glutamate-binding site, leading to an enhancement of the GABAAR function. Comparing with traditional benzodiazepine drugs, these two compounds were able to regulate both synaptic and extrasynaptic GABAARs. In the cerebellum, depolarization of the Purkinje cells induces both dendritic glutamate release and a rebound potentiation of GABA responsiveness. Application of ampicillin occluded the early phase of rebound potentiation, presumably by saturating the glutamate-binding site on the GABAARs and preventing the further potentiation induced by dendritically released glutamate. Taken together, our present study demonstrated a novel glutamate-binding site on the GABAAR that might lead to future development of novel GABAAR-based therapeutics. This type of excitation/inhibition crosstalk may play an essential role in Purkinje cell inhibitory plasticity.
Magnetic Properties and Thermal Entanglement on a Triangulated Kagome Lattice
Creators: name: Ananikian, N. S.
name: Ananikyan, L. N.
name: Chakhmakhchyan, L. A.
name: Kocharian, A. N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The magnetic and entanglement thermal (equilibrium) properties in spin-1/2 Ising-Heisenberg model on a triangulated Kagome lattice are analyzed by means of variational mean-field like treatment based on Gibbs-Bogoliubov inequality. Because of the separable character of Ising-type exchange interactions between the Heisenberg trimers the calculation of quantum entanglement in a self-consistent field can be performed for each of the trimers individually. The concurrence in terms of three qubit isotropic Heisenberg model in effective Ising field is non-zero even in the absence of a magnetic field. The magnetic and entanglement properties exhibit common (plateau and peak) features observable via (antferromagnetic) coupling constant and external magnetic field. The critical temperature for the phase transition and threshold temperature for concurrence coincide in the case of antiferromagnetic coupling between qubits. The existence of entangled and disentangled phases in saturated and frustrated phases is established.
description: 21 pages, 13 figures
Additional file 1 of Patient decision aid for trial of labor after cesarean (TOLAC) versus planned repeat cesarean delivery: a quasi-experimental pre-post study
Creators: name: Venkatesh, Kartik K.
name: Brodney, Suzanne
name: Barry, Michael J.
name: Jackson, Jamie
name: Lyons, Kiira M.
name: Talati, Asha N.
name: Ivester, Thomas S.
name: Munoz, Maria C.
name: Thorp, John M.
name: Nicholson, Wanda K.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Additional file 1 of Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients
Creators: name: Lin, Chih-Hsiang
name: Ho, Chen-Jui
name: Lu, Yan-Ting
name: Tsai, Meng-Han
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplement Table. The response of individual sodium channel blocking antiseizure medications in patients with rs55742440T > C.
Parameters influencing the mass loss rate in the tube furnace for PMMA
Creators: name: De Lannoye, Karen
name: Belt, Alexander
name: Reinecke, Ernst-Arndt
name: Arnold, Lukas
Publisher: name: Forschungzentrum Jülich
Year: 2023

description: 14th International Symposium on Fire Safety Science, Tsukuba, Japan, 23 Oct 2023 - 27 Oct 2023
Additional file 1 of Screening high-risk population of persistent postpartum hypertension in women with preeclampsia using latent class cluster analysis
Creators: name: Li, Yuan-Yuan
name: Cao, Jing
name: Li, Jia-Lei
name: Zhu, Jun-Yan
name: Li, Yong-Mei
name: Wang, De-Ping
name: Liu, Hong
name: Yang, Hai-Lan
name: He, Yin-Fang
name: Hu, Li-Yan
name: Zhao, Rui
name: Zheng, Chu
name: Zhang, Yan-Bo
name: Cao, Ji-Min
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Goodness-of-fit indicators for the five different class models. Table S2. Comparison of risk factors among the three clusters of PE patients. Table S3. Class assignment for a minority of PE patients.
Pulse profile stability of the Crab pulsar
Creators: name: Jain, Chetana
name: Paul, Biswajit
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present an X-ray timing analysis of the Crab pulsar, PSR B0531+21, using the archival RXTE data. We have investigated the stability of the Crab pulse profile, in soft (2-20 keV) and hard (30-100 keV) X-ray energies, over the last decade of RXTE operation. The analysis includes measurement of the separation between the two pulse peaks; and intensity and the widths of the two peaks. We did not find any significant time dependency in the pulse shape. The two peaks are stable in phase, intensity and widths, for the last ten years. The first pulse is relatively stronger at soft X-rays. The first pulse peak is narrower than the second peak, in both, soft- and hard X-ray energies. Both the peaks show a slow rise and a steeper fall. The ratio of the pulsed photons in the two peaks is also constant in time.
description: 9 pages, 5 figures, 1 table; accepted for publication in "Research In Astronomy and Astrophysics"
Radio-submm flares from blazars in a discontinuous jet model
Creators: name: Rachen, Jörg P.
name: Häberlein, Max
name: Reimold, Felix
name: Krichbaum, Thomas
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present a model in which AGN jets are described by a dense series of plasma blobs, distributed in masses and velocities. The blobs expand and collide, and ultimately form a continuous jet flow as observed on larger scales. When blobs collide, energetic electrons are produced by first order Fermi acceleration, and emit synchrotron radiation at the radio-optical frequencies with a double-broken power law spectrum. The difference of this model to the well-known Marscher&Gear-model is, that in our model shocks are produced on a range of scales, and exist only temporarily, which causes differences in the prediction for the spectral evolution of flares. We apply our model to radio-submm data obtained for 3C454.3, and briefly discuss implications for gamma-ray production.
description: 4 pages, 2 figures, some minor errors corrected compared to proceedings version
Suche nach der Produktion einzelner Top-Quarks durch Flavor-ändernde neutrale Ströme mit dem CDF II Experiment
Creators: name: Papaikonomou, Antonios
Publisher: name: Karlsruhe
Year: 2009
Subjects: Hochenergiephysik
Beschleuniger
Tevatron
FCNC
anomale Kopplungen
BSM
Datenanalyse
neuronale Netzwerke

description: Verschiedene phaenomenologische Erweiterungen des Standard Modells sagen die Produktion von Einzel-Top-Quarks mittels Flavor-aendernden Neutralen Stroemen (FCNC) in fuehrender Ordnung vorher. Ein Beispiel fuer einen solchen Prozess ist u(c)+g->t, wobei ein Up-Quark, bzw. ein Charm-Quark, mit einem Gluon wechselwirkt und in ein Top-Quark uebergeht. Zur Suche danach werden Daten des CDF II Experiments mit der Signatur von einem Jet, fehlender Transversalenergie und einem Lepton verwendet.
On the power-law q-distribution function based on the probabilistically independent postulate in nonextensive statistics
Creators: name: Du, Jiulin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We deal with the power-law q-distribution functions, so-called q-exponentials in nonextensive statistics. The system considered is a many-body Hamiltonian system with arbitrary interacting potentials. We find that the usual form of power-law q-distribution function employed in nonextensive statistics for the system may be not to stand by the probabilistically independent postulate and it only represents a dynamical isothermal situation. The probabilistically independent postulate is validated by the nonextensivity (or pseudoadditivity) in nonextensive statistics and thus the usual forms of power-law q-distribution function have to be modified. In this letter, we present a new power-law q-distribution based on the probabilistically independent postulate, which can represent nonequilibrium stationary state of the system away from equilibrium and with the nonextensive energy.
description: 9 pages
Codeco: A Grammar Notation for Controlled Natural Language in Predictive Editors
Creators: name: Kuhn, Tobias
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: H.5.2; F.4.2

description: Existing grammar frameworks do not work out particularly well for controlled natural languages (CNL), especially if they are to be used in predictive editors. I introduce in this paper a new grammar notation, called Codeco, which is designed specifically for CNLs and predictive editors. Two different parsers have been implemented and a large subset of Attempto Controlled English (ACE) has been represented in Codeco. The results show that Codeco is practical, adequate and efficient.
Numerical solution of an optimal control problem with probabilistic and almost sure state constraints
Creators: name: Geiersbach, Caroline
name: Henrion, René
name: Pérez-Aroz, Pedro
Publisher: name: Weierstrass Institute
Year: 2023
Subjects: subject: Stochastic optimization
subject: risk averse PDE-constrained optimization under chance constraints
subject: almost sure constraints
subject: robust constraints
subject: 49K20
subject: 49K45
subject: 35Q93
subject: 49J52
subject: 90C15

description: We consider the optimal control of a PDE with random source term subject to probabilistic or almost sure state constraints. In the main theoretical result, we provide an exact formula for the Clarke subdifferential of the probability function without a restrictive assumption made in an earlier paper. The focus of the paper is on numerical solution algorithms. As for probabilistic constraints, we apply the method of spherical radial decomposition. Almost sure constraints are dealt with a Moreau-Yosida smoothing of the constraint function accompanied by Monte Carlo sampling of the given distribution or its support or even just the boundary of its support. Moreover, one can understand the almost sure constraint as a probabilistic constraint with safety level one which offers yet another perspective. Finally, robust optimization can be applied efficiently when the support is sufficiently simple. A comparative study of these five different methodologies is carried out and illustrated.
Additional file 1 of Chemical profiling and antioxidant activity of Equisetum ramosissimum Desf. stem extract, a potential traditional medicinal plant for urinary tract infections
Creators: name: Sureshkumar, Jeyalatchagan
name: Amalraj, Singamoorthy
name: Murugan, Ramar
name: Tamilselvan, Anantharaj
name: Krupa, Jayaraj
name: Sriramavaratharajan, Venkatraman
name: Gurav, Shailendra S.
name: Ayyanar, Muniappan
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: Plant Biology

description: Additional file 1. Results of the minimum inhibitory concentrations of E. ramosissimum stem extracts.
Internationalisierung  der Versicherungsrechnungslegung in China
Creators: name: Xu, Xian
Publisher: name: Karlsruhe
Year: 2010
Subjects: Versicherungsrechnungslegung
China
Versicherung
Internationale Rechnungslegung
China-GAAP

description: In der vorliegenden Dissertation wird untersucht, inwiefern die Vorschriften zur Rechnungslegung von Versicherungsunternehmen in China mit denjenigen nach IFRS konvergieren, d.h., wie sich China durch Reformen des Rechnungslegungsrechts schrittweise an die IFRS annähert. Hierbei wird der gegenwärtige chinesische Rechnungslegungsrahmen auch kritisch diskutiert.
The Number of Same-Sex Marriages in a Perfectly Bisexual Population is Asymptotically Normal
Creators: name: Ekhad, Shalosh B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Why bother with fully rigorous proofs when one can very quickly get semi-rigorous ones? Yes, yes, we know how to get a "rigorous" proof of the result stated in the title of this article. One way is the boring, human one, citing some heavy guns of theorems that already exist in the literature. We also know how to get a fully rigorous proof automatically, using the methods in this http://www.math.rutgers.edu/~zeilberg/mamarim/mamarimhtml/georgy.htm neat article (but it would be a little more complicated, since the probability generating polynomial is not "closed form" but satisfies a second-order recurrence gotten from the Zeilberger algorithm), otherwise the same method would work, alas, it is not yet implemented. Instead, we chose to use the great Maple package http://www.math.rutgers.edu/~zeilberg/tokhniot/HISTABRUT">HISTABRUT(in fact, a very tiny part of it, procedure AlphaSeq), explained in this other http://www.math.rutgers.edu/~zeilberg/mamarim/mamarimhtml/histabrut.html">neat article, and get a semi-rigorous proof. We also needed the nice little Maple package http://www.math.rutgers.edu/~zeilberg/tokhniot/GuessRat">GuessRat, to do the guessing of rational functions. Equipped with these two packages, Zeilberger wrote a short Maple program http://www.math.rutgers.edu/~zeilberg/tokhniot/SameSexMarriages">SameSexMarriages that enabled the author to generate this paper.
description: 3 pages
Additional file 1 of Barriers of Ukrainian refugees and migrants in accessing German healthcare
Creators: name: Davitian, Karina
name: Noack, Peter
name: Eckstein, Katharina
name: Hübner, Jutta
name: Ahmadi, Emadaldin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.  Interview Guide.  The detailed interview guide used while performing the interviews.
Additional file 1 of User experiences and perceptions of health wearables: an exploratory study in Cambodia
Creators: name: Liverani, Marco
name: Ir, Por
name: Wiseman, Virginia
name: Perel, Pablo
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Survey questionnaires.
The role of mitochondrial (intrinsic) apoptotic pathway in hIAPP mediated β-cell death
Creators: name: Wong, Helen Yunshan
Publisher: name: University of British Columbia
Year: 2018

description: Type 2 diabetes (T2D) is a complex and heterogeneous metabolic disorder characterized by insulin deficiency due to progressive loss of pancreatic β-cell function/mass and insulin resistance in peripheral tissues. Islet amyloid is a common pathologic characteristic of the pancreas in patients with T2D which also forms in cultured and transplanted human islets. Intra- and extra-cellular amyloid formation due to aggregation of the β-cell peptide human islet amyloid polypeptides (hIAPP) contributes to progressive β-cell dysfunction and death in T2D and islet grafts. Our research group previously showed that blocking the amyloid-induced Fas-mediated apoptotic pathway markedly reduces, but does not completely prevent, amyloid toxicity. Since hIAPP aggregates also form intracellularly, we proposed to investigate the potential role of mitochondrial-dependent (intrinsic) apoptotic pathway in amyloid-induced β-cell toxicity. In the present study, we examined if intracellular hIAPP aggregates can initiate the mitochondrial apoptotic pathway and tested if blocking this pathway protects β-cells from toxic hIAPP aggregates. INS-1 transformed rat β-cells and dispersed human islet cells were transduced with an adenovirus that codes for the expression of hIAPP (Ad-prohIAPP; to form intracellular hIAPP aggregates) or non-fibrillogenic rIAPP (Ad-prorIAPP; as control) and cultured with or without the inhibitor of Bax or caspase-9 (to block the intrinsic apoptotic pathway). Adenoviral mediated hIAPP expression and formation of intracellular hIAPP oligomers in both transformed INS-1 β-cells and primary human islet β-cells increased cytochrome c release leading to caspase-9 activation and β-cell apoptosis, both of which were prevented by Bax or caspase-9 inhibitor. We next used mouse islets isolated from CytcKA/KA and BaxBak DKO mice transduced with Ad-prohIAPP, as two models of ex vivo hIAPP aggregation with blocked intrinsic apoptotic pathway. Blocking the pro-apoptotic function of cytochrome c (CytcKA/KA) or activation of Bax and Bak (BaxBak DKO) in islets, prevented activation of the mitochondrial apoptotic pathway mediated by intracellular hIAPP aggregates and enhanced β-cell survival as compared to wild-type islets despite comparable hIAPP aggregation. These data suggest that: 1) intracellular hIAPP aggregates trigger the mitochondrial apoptotic pathway in islet β-cells; 2) blocking the pro-apoptotic function of cytochrome c or deletion of Bax and Bak protects islet β-cells from hIAPP aggregates.
Ergänzendes Material zu: Dekarbonsierung des Verkehrssektors in Berlin – Burger:innengutachten zu wissenschaftlich erstellten Szenarien
Creators: name: Kreuschner, Moritz
name: Schlenther, Tilmann
name: Bonatz, Nora
name: Mostofi, Hamid
name: Dienel, Hans-Liudger
name: Nagel, Kai
Publisher: name: Technische Universität Berlin
Year: 2023
Subjects: subject: 300 Sozialwissenschaften::380 Handel, Kommunikation, Verkehr::388 Verkehr; Landverkehr
subject: 300 Sozialwissenschaften::300 Sozialwissenschaften, Soziologie::303 Gesellschaftliche Prozesse
subject: 000 Informatik, Informationswissenschaft, allgemeine Werke::000 Informatik, Wissen, Systeme::006 Spezielle Computerverfahren
subject: Berlin's transport sector
subject: decarbonization
subject: citizen council
subject: Dekarbonisierung
subject: Bürger:innengutachten
subject: Verkehrssektor
subject: non-fossil scenarios
subject: nicht-fossile Szenarien
subject: Defossilisierung
subject: defossilization
subject: Berlin

description: Diese Forschungsdaten wurden beim Workshop innerhalb des Projekts Bürgerschaftliche Resonanz auf nachhaltige Mobilitäts- und Infrastrukturszenarien für Berlin erhoben. Unterschiedlichen Maßnahmen für eine Dekarbonisierung des Berliner Verkehrssektors wurden in Workshops mit Bürger:innen aus Berlin und Brandenburg, die als Bürgergutachter:innen agieren, kontrovers und alternativ diskutiert und darüber abgestimmt. Dies bildet den Anhang des Preprints Dekarbonsierung des Verkehrssektors in Berlin: Bürger:innengutachten zu wissenschaftlich erstellten Szenarien. Der Preprint ist erreichbar unter DOI: https://doi.org/10.14279/depositonce-18736.
Interpreting narratives of no return : Canadian asylum claim decisions and the emergence of the “anti-refugee”
Creators: name: Demian, Diana Nasr
Publisher: name: University of British Columbia
Year: 2016

description: This thesis argues that, firstly, in reading asylum claim decisions, the search for the claimant’s “narrative” must end and a search for its “interpretation” by adjudicators must begin. In endorsing such an “interpretive turn,” I seek to understand how conceptual and discursive formulations of “the refugee” and “the asylum seeker” — two figures currently imagined in contradistinction to one another through a “myth of difference” — colour how the latter is encountered and subsequently “read” by adjudicators in the hearing room. Accordingly, I engage in a close-reading of asylum claims decisions, focusing on a manifestation of the “asylum seeker” seldom invoked: a woman, fleeing a situation in the Global South not readily identified as being “persecutory,” and who frustrates our attempts at locating the 21st century’s “authentic” refugee. This latter figure is imagined to be a helpless, immobile woman, often with a child or two in tow, who suffers “legitimate” horrors and untold traumas. My reading aims to explore how the female asylum seeker that I briefly profile above tends to be read, to her detriment, against this formidable invocation of the “authentic” refugee in the hearing room.
Converging an Overlay Network to a Gradient Topology
Creators: name: Terelius, Håkan
name: Shi, Guodong
name: Dowling, Jim
name: Payberah, Amir
name: Gattami, Ather
name: Johansson, Karl Henrik
Publisher: name: arXiv
Year: 2011
Subjects: subject: Systems and Control (eess.SY)
subject: Optimization and Control (math.OC)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics

description: In this paper, we investigate the topology convergence problem for the gossip-based Gradient overlay network. In an overlay network where each node has a local utility value, a Gradient overlay network is characterized by the properties that each node has a set of neighbors with the same utility value (a similar view) and a set of neighbors containing higher utility values (gradient neighbor set), such that paths of increasing utilities emerge in the network topology. The Gradient overlay network is built using gossiping and a preference function that samples from nodes using a uniform random peer sampling service. We analyze it using tools from matrix analysis, and we prove both the necessary and sufficient conditions for convergence to a complete gradient structure, as well as estimating the convergence time and providing bounds on worst-case convergence time. Finally, we show in simulations the potential of the Gradient overlay, by building a more efficient live-streaming peer-to-peer (P2P) system than one built using uniform random peer sampling.
description: Submitted to 50th IEEE Conference on Decision and Control (CDC 2011)
Additional file 1 of Valuing child and adolescent health: a qualitative study on different perspectives and priorities taken by the adult general public
Creators: name: Powell, Philip A.
name: Rowen, Donna
name: Rivero-Arias, Oliver
name: Tsuchiya, Aki
name: Brazier, John E.
Publisher: name: figshare
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Appendix A–D.
Prozessstudien der stratosphärischen Chemie und Dynamik mit Hilfe des Chemie-Klima-Modells ECHAM5/MESSy1
Creators: name: Kirner, Oliver
Publisher: name: Karlsruhe
Year: 2008
Subjects: Ozonschicht
Klimaänderung
PSC
Atmosphärenchemie
Meteorologie

description: Im Chemie-Klima-Modell ECHAM5/MESSy1 wurde eine neue Parameterisierung der Polaren Stratosphärischen Wolken (PSC) implementiert und deren Auswirkung auf die polare Ozonchemie untersucht. Der neue PSC-Algorithmus berücksichtigt dabei unter anderem das Wachstum und die Sedimentation von NAT-Partikeln im polaren Wirbel.
An innovative mathematical solution for a time-efficient IVS reference point determination
Creators: name: Lösler Michael
name: Maria, Hennes
Publisher: name: Karlsruhe
Year: 2008

description: The improvement of the local ties between different observation methods (GPS, VLBI, etc.) improves the quality of the ITRF considerably. The IVS reference point of a VLBI radio telescope is defined as the intersection between the azimuth- and elevation-axis or, if they do not intersect, the intersection of the right-angle projection from the elevation-axis onto the azimuth-axis. In the past, these axes have been estimated by fitting 3D circles, e.g. (Eschelbach et al., 2003) or (Dawson et al., 2006). The data acquisition for the determination of the circles requires that the telescope has to be moved into clearly defined positions; therefore, the basic station process (data gathering for the intrinsic telescope task) is disturbed. In this paper we present an alternative mathematical model, which computes the reference point without circle fitting. This algorithm does not need observations from predefined telescope positions and therefore the station's downtime can be reduced. The parameter estimation of this non-linear problem is implemented in two steps. At first we are using the Levenberg-Marquardt-Algorithm for a pre-evaluation to find stable approximate values (Madsen et al., 2004), which we use for the main least-square-model in a second step.
MO analysis of the high statistics Belle results on $γγ\to π^+π^-,π^0π^0$ with chiral constraints
Creators: name: Garcia-Martin, R.
name: Moussallam, B.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We reconsider Muskhelishvili-Omnès (MO) dispersive representations of photon-photon scattering to two pions, motivated by the very high statistics results recently released by the Belle collaboration for charged as well as neutral pion pairs and also by recent progress in the determination of the low-energy $ππ$ scattering amplitude. Applicability of this formalism is extended beyond 1 GeV by taking into account inelasticity due to $K\bar{K}$ . A modified MO representation is derived which has the advantage that all polynomial ambiguities are collected into the subtraction constants and have simple relations to pion polarizabilities. It is obtained by treating differently the exactly known QED Born term and the other components of the left-hand cut. These components are approximated by a sum over resonances. All resonances up to spin two and masses up to $\simeq1.3$ GeV are included. The tensor contributions to the left-hand cut are found to be numerically important. We perform fits to the data imposing chiral constraints, in particular, using a model independent sum rule result on the $p^6$ chiral coupling $c_{34}$. Such theoretical constraints are necessary because the experimental errors are dominantly systematic. Results on further $p^6$ couplings and pion dipole and quadrupole polarizabilities are then derived from the fit. The relevance of the new data for distinguishing between two possible scenarios of isospin breaking in the $f_0(980)$ region is discussed.
description: 44 pages, 12 figures
Radiation driven winds with rotation: The oblate finite disc correction factor
Creators: name: Araya, Ignacio
name: Curé, Michel
name: Granada, Anahí
name: Cidale, Lydia
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have incorporated the oblate distortion of the shape of the star due to the stellar rotation, which modifies the finite disk correction factor (f_D) in the m-CAK hydrodynamical model. We implement a simplified version for the f_D allowing us to solve numerically the non-linear m- CAK momentum equation.We solve this model for a classical Be star in the polar and equatorial directions. The star's oblateness modifies the polar wind, which is now much faster than the spherical one, mainly because the wind receives radiation from a larger (than the spherical) stellar surface. In the equatorial direction we obtain slow solutions, which are even slower and denser than the spherical ones. For the case when the stellar rotational velocity is about the critical velocity, the most remarkable result of our calculations is that the density contrast between the equatorial density and the polar one, is about 100. This result could explain a long-standing problem on Be stars.
description: 2 pages, to appear in the proceedings of the IAUS 272 on "Active OB stars: structure, evolution, mass loss and critical limits" (Paris, July 19-23, 2010), Cambridge University Press. Editors C. Neiner, G. Wade, G. Meynet and G. Peters
Additional file 1 of A novel dosimetric metrics-based risk model to predict local recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy
Creators: name: Liao, Wenjun
name: He, Jinlan
name: Liu, Zijian
name: Tian, Maolang
name: Yang, Jiangping
name: Han, Jiaqi
name: Xiao, Jianghong
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 1: Supplementary Table 1. Univariate analysis of dosimetrics by Cox regression model.
Additional file 2 of A novel dosimetric metrics-based risk model to predict local recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy
Creators: name: Liao, Wenjun
name: He, Jinlan
name: Liu, Zijian
name: Tian, Maolang
name: Yang, Jiangping
name: Han, Jiaqi
name: Xiao, Jianghong
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 2: Supplementary Table 2. Two parameters from multivariate Cox regression analysis were used to develop model.
Additional file 1 of Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital
Creators: name: Shimizu, Norihiro
name: Oshitari, Toshiyuki
name: Yotsukura, Jiro
name: Yokouchi, Hirotaka
name: Baba, Takayuki
name: Yamamoto, Shuichi
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. Graphical illustration of the frequencies of major malignant eyelid tumors.
Characterization of the disease pathogenesis of Schimke immuno-osseous dysplasia
Creators: name: Morimoto, Marie
Publisher: name: University of British Columbia
Year: 2017

description: Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive multisystemic disorder characterized by disproportionate short stature due to skeletal dysplasia, renal disease due to focal segmental glomerulosclerosis (FSGS), T-cell immunodeficiency, and vascular disease. SIOD is caused by mutations in the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin, subfamily A-like 1 (SMARCAL1) gene, which encodes for a DNA annealing helicase with roles in DNA replication, DNA repair, and gene expression. Although SMARCAL1 functions to maintain genomic integrity, it is not known how SMARCAL1 deficiency leads to the various clinical features of SIOD. My aim was therefore to characterize the molecular pathogenesis of the dental, vascular, renal, and immune features. Given that SMARCAL1 has a role in modulating gene expression and that phenotypic changes are typically preceded by changes in gene expression, I hypothesized that SMARCAL1 deficiency pathologically alters the expression of key genes that lead to the clinical features of SIOD. To test this, SIOD patient tissues were studied using molecular biological analyses. With respect to vascular disease, an SIOD aorta had decreased expression of elastin, and both transcriptional and post-transcriptional mechanisms contributed to the elastin deficiency. Elastin is critical for the structural integrity of the arteries and its deficiency is a known cause of vascular disease. With respect to renal disease, SIOD glomeruli have increased expression and activation of the Wnt and Notch signaling pathways. Wnt and Notch signaling are required for kidney development and the postnatal reactivation of these pathways is an established cause of FSGS. With respect to immune disease, SIOD T cells have decreased mRNA and protein expression of interleukin 7 receptor alpha chain (IL7R). IL7R is critical for T-cell development and its deficiency is a known cause of T-cell immunodeficiency. In conclusion, the gene expression alterations detected are known causes of disease and differ among the tissues studied. These findings suggest that SMARCAL1 deficiency may cause each disease feature by tissue-specific gene expression changes. Further studies are required to define the mechanism of how SMARCAL1 deficiency alters the expression of these genes.
Could nanostructure be unspeakable quantum system?
Creators: name: Aristov, V. V.
name: Nikulov, A. V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Physics (physics.gen-ph)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: Heisenberg, Bohr and others were forced to renounce on the description of the objective reality as the aim of physics because of the paradoxical quantum phenomena observed on the atomic level. The contemporary quantum mechanics created on the base of their positivism point of view must divide the world into speakable apparatus which amplifies microscopic events to macroscopic consequences and unspeakable quantum system. Examination of the quantum phenomena corroborates the confidence expressed by creators of quantum theory that the renunciation of realism should not apply on our everyday macroscopic world. Nanostructures may be considered for the present as a boundary of realistic description for all phenomena including the quantum one.
description: 3 pages, 0 figures
Pulse delay via tunable white light cavities using fiber optic resonators
Creators: name: Yum, Honam
name: Jang, Youngjoon
name: Kim, May
name: Liu, Xue
name: Shahriar, Selim
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Previously, we proposed a data buffering system that makes use of a pair of white light cavities. For application to telecommunication systems, it would be convenient to realize such a device using fiber optic resonators. In this paper, we present the design of such a system, where the white light cavity effect is produced by using stimulated Brillouin scattering. The system consists of a pair of fiber optic white light cavities placed in series. As in the original proposal, the delay time can be controlled independently of the bandwidth of the data pulses. Furthermore, we show how the bandwidth of the system can be made as large as several times the Brillouin frequency shift. We also show that the net delay achievable in such a buffer can be significantly larger than what can be achieved using a conventional recirculating loop buffer.
description: 13 pages, 8 figures
Statistical properties of $r$-adic processes and their connections to families of popular fractal curves
Creators: name: Dorfman, J. R.
name: Gilbert, Thomas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Results concerning the statists of $r$-adic processes and their fractal properties are reviewed. The connection between singular eigenstates of the statistical evolution of such processes and popular fractal curves is emphasized.
description: Submitted as part of a volume honoring the memory of Shuichi Tasaki
Influence of flux balance on the generalized chemical potential in mass transport models
Creators: name: Martens, Kirsten
name: Bertin, Eric
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In equilibrium systems, the conservation of the number of particles (or mass) leads to the equalization of the chemical potential throughout the system. Using a non-equilibrium generalization of the notion of chemical potential, we investigate the influence of disorder and of the balance of mass fluxes on the generalized chemical potential in the framework of stochastic mass transport models. We focus specifically on the issue of local mesurements of the chemical potential. We find that while local dynamical disorder does not affect the measurement process, the presence of large-scale geometrical heterogeneities (branching geometry) leads to unequal local measurement results in different points of the system. We interpret these results in terms of mass flux balance, and argue that the conditions for the global definition of the chemical potential still hold, but that local measurements fail to capture the global theoretical value.
description: 14 pages, 7 figures