cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supplementary Material for: ADULT Phenotype and rs16864880 in the TP63 Gene: Two New Cases and Review of the Literature
Creators: name: Kawasaki De Araujo, T.
name: Lustosa-Mendes, E.
name: Dos Santos, A.P.
name: Coelho Molck, M.
name: Mazzariol Volpe-Aquino, R.
name: Gil-Da-Silva-Lopes, V.L.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: The TP63 gene has been described in 5 overlapping limb malformation disorders, including a rare autosomal dominant ectodermal disorder named acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome. This article describes 2 patients with ectrodactyly and variable features related to ectodermal dysplasia/ADULT syndrome, and the polymorphism rs16864880 in the TP63 gene, which was not present in their parents. The role of this variant in the genesis of this condition is discussed, based upon a review of 40 cases. The results suggested that rs16864880 may not be directly related to ADULT syndrome. However, it is not possible to exclude its participation in gene interactions in the limb development pathway.
Table S2 from Climate predicts which sex acts as helpers among cooperatively breeding bird species
Creators: name: Zhang, Guoyue
name: Zhao, Qingtian
name: Pape Møller, Anders
name: Komdeur, Jan
name: Lu, Xin
Publisher: name: The Royal Society
Year: 2017

description: A summary of Bayesian phylogenetic mixed models showing the significant predictors of sex bias in helping (male-only or both-sex) across 88 cooperatively breeding bird species. Predictor variables were selected following a stepwise forward regression method.
СОЦИАЛЬНЫЙ ПРОЕКТ В СФЕРЕ ОБРАЗОВАНИЯ С ИСПОЛЬЗОВАНИЕМ ПРАКТИКИ ПРОВЕДЕНИЯ ЧЕМПИОНАТОВ JUNIORSKILLS
Creators: name: А. В. Кудинова
name: В. Л. Тищенко
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: профориентация
выбор
квалификация
JuniorSkills
профессия

description: В научной статье рассмотрена одна из актуальнейших для нашего времени тем – профориентация школьников. Проведен анализ данной проблемы и предложена практика использования чемпионатов JuniorSkills, как эффективный способ качественной профориентации. Новое движение охватывает более 80 рабочих профессий, что позволяет школьнику определиться с будущей деятельностью, осознать возможности, склонности и выявить свои таланты. В данной работе профориентационная деятельность рассмотрена на примере V Регионального чемпионата Краснодарского края. Авторами доказано, что данная профориентационнная работа имеет перспективное значение для школьников, является основой для их профессионального развития, формирования у обучающегося понимания будущей профессии, оценки своих возможностей и приоритетов.
Utility values associated with advanced or metastatic non-small cell lung cancer: data needs for economic modeling
Creators: name: Brown, Jacqueline
name: Keziah Cook
name: Adamski, Kelly
name: Lau, Jocelyn
name: Bargo, Danielle
name: Breen, Sarah
name: Chawla, Anita
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Introduction: Cost-effectiveness analyses often inform healthcare reimbursement decisions. The preferred measure of effectiveness is the quality adjusted life year (QALY) gained, where the quality of life adjustment is measured in terms of utility. Areas covered: We assessed the availability and variation of utility values for health states associated with advanced or metastatic non-small cell lung cancer (NSCLC) to identify values appropriate for cost-effectiveness models assessing alternative treatments. Our systematic search of six electronic databases (January 2000 to August 2015) found the current literature to be sparse in terms of utility values associated with NSCLC, identifying 27 studies. Utility values were most frequently reported over time and by treatment type, and less frequently by disease response, stage of disease, adverse events or disease comorbidities. Expert commentary: In response to rising healthcare costs, payers increasingly consider the cost-effectiveness of novel treatments in reimbursement decisions, especially in oncology. As the number of therapies available to treat NSCLC increases, cost-effectiveness analyses will play a key role in reimbursement decisions in this area. Quantifying the relationship between health and quality of life for NSCLC patients via utility values is an important component of assessing the cost effectiveness of novel treatments.
Equilibrium strategies of channel structure and RFID technology deployment in a supply chain with manufacturer encroachment
Creators: name: Zhang, Li-Hao
name: Tian, Lin
name: Chang, Lu-Yu
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: The rapid growth of online marketplaces and the advance of Internet technology have enabled manufacturers to more easily engage in direct selling through their own online stores. However, as any retail channel suffers misplacements, the manufacturer's direct sales channel will also face a critical inventory misplacement problem if it chooses encroachment. Radio-frequency identification (RFID) proven to be the most effective technology to eliminate the inventory misplacement problem. This paper investigates the strategic interaction between manufacturer encroachment and RFID deployment decisions in a supply chain consisting of a manufacturer and a reseller. We find that the manufacturers’ encroachment strategies are determined by channels’ misplacement rates, RFID deployment decisions and channel competition intensity. Specifically, the retail (direct) channel's misplacement problem encourages (discourages) the manufacturer to encroach; in addition, if only the retail (if it is direct) channel employs RFID, the encroachment cost threshold increases (decreases) with the RFID tag price; moreover, the more intense the channel competition is, the less likely the manufacturer will be to encroach. Further, when encroachment has occurred, channel competition will be a crucial factor in the direct channel's RFID deployment decision, but it will not affect the deployment of RFID in the retail channel.
State of the art, conceptual framework and simulation analysis of the ripple effect on supply chains
Creators: name: Llaguno, Arrate
name: Mula, Josefa
name: Campuzano-Bolarin, Francisco
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Supply chains are becoming increasingly sophisticated and vital for many firms’ competetiveness. Nevertheless, their interrelated, complex and global nature also makes them more vulnerable to the risk of their operations being interrupted. This article analyzes the ripple effect on supply chains, which occurs when disruption in one node spreads throughout the supply chain and impacts its performance, design and planning parameters. This article offers a systematic review of the existing literature that covers the ripple effect in the supply chain context. It structures and classifies existing research currents and application areas in this context by presenting and analyzing the obtained results. Based on the conclusions obtained with the literature review, a conceptual framework is proposed and includes the main characteristics and perspectives of the ripple effect on supply chains, and the possible proactive and reactive measures to mitigate its effects and to recover from serious disruptions. The conceptual framework is also analyzed and validated by a system dynamics simulation model.
ЦИФРОВЫЕ ДОКУМЕНТЫ АРХИВНОГО ФОНДА: ПРОБЛЕМЫ И МЕТОДЫ ОБЕСПЕЧЕНИЯ ДОЛГОСРОЧНОЙ ЧИТАЕМОСТИ
Creators: name: Д. В. Ланская
name: Е. С. Яковлева
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: Архивный фонд
цифровая экономика
образ документа
программно-аппаратная платформа
электронный документ
сохранность цифрового документа
механизм комплектования

description: Целью данной статьи является определение тенденций развития архивной отрасли в условиях становления цифровой экономики. В статье рассматриваются проблемы формирования Архивного фонда при трансформации программно – аппаратных платформ. Для достижения поставленной цели были решены следующие задачи: проведен анализ различных вариантов долгосрочного хранения электронных документов как в России, так и за рубежом, выявлены направления и перспективы его применения. Исследование проводилось с использованием методов системного, логического, сравнительного анализа, группировки и обобщения, позволивших обеспечить обоснованность результатов и выводов. Разработан метод долгосрочного хранения электронных документов, даны рекомендации по обеспечению сохранности электронных документов при трансформации программно – аппаратных платформ. Благодаря всеобщей информатизации и цифровизации электронные документы становятся основными единицами хранения. Поэтому актуализируется потребность в исследовании методов и способов обеспечения не только их сохранности, безопасности, но и их живучести. Способность архивов обеспечивать читаемость любого электронного документа в условиях перехода от использования одних программно – аппаратных платформ к другим можно отнести к новым возможностям архивов. Такое свойство на языке теории систем можно назвать эквифинальной читаемостью документа долгосрочного хранения на протяжении всего жизненного цикла.
Integrated optimisation of storage and pre-marshalling moves in a slab warehouse
Creators: name: Ge, Peixin
name: Zhao, Ren
name: Sun, Defeng
name: Dong, Yun
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: In the slab warehouses of iron and steel enterprises, the slabs are stacked on top of others. Thus, some slabs will be blocked by others from being retrieved directly. In this study, we focus on optimising slab storage and pre-marshalling moves in advance so as to minimise the numbers of slabs which may block retrieval slab, the number of stacks occupied by slabs, and the number of required moves. We also address the practical concern of moving no more than two slabs together. To solve this problem, we present an integer linear programming model and further propose valid inequalities to enhance the model. Based on the labelled data from this modelling approach, a self-training technique is applied to train two functions which can predict the optimal following pre-marshalling move and storage move. By combining these functions, heuristics and branch-and-bound algorithm with the dominance rules, a multi-stage hybrid algorithm is proposed to solve practical problems. The experimental results show the effectiveness of the model, the valid inequalities, and the different components of hybrid algorithm which can produce high-quality solutions within seconds.
КОНТУРЫ СОВРЕМЕННОЙ ТАРИФНОЙ ПОЛИТИКИ В СФЕРЕ ВОДОСНАБЖЕНИЯ И ВОДООТВЕДЕНИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Т. В. Мартыненко
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: тариф
тарифная политика
цифровизация
водоснабжение
водоотведение
регулирование
инвестиции

description: В статье рассмотрены современные подходы к тарифной политике в водоснабжении и водоотведении в Российской Федерации, показана противоречивость в ее реализации, связанная с разнонаправленностью интересов. С одной стороны, Правительство РФ демонстрирует свое стремление к социальной справедливости и учету интересов потребителей, пытаясь ограничить рост тарифов. С другой стороны, состояние систем водоснабжения и водоотведения в стране требует модернизации и привлечения значительных инвестиций, что неизбежно ведет к росту тарифов. Раскрыт современный механизм формирования тарифов в условиях цифровизации экономики.
Supplementary Material for: Comparison of pro re nata versus Bimonthly Injection of Intravitreal Aflibercept for Typical Neovascular Age-Related Macular Degeneration
Creators: name: Mori, R.
name: Tanaka, K.
name: Haruyama, M.
name: Kawamura, A.
name: Furuya, K.
name: Yuzawa, M.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Purpose: The aim of this study was to clarify the 1-year outcomes of pro re nata (PRN) and bimonthly intravitreal injections of aflibercept (IVA) for typical neovascular age-related macular degeneration (tAMD) after the initial 3 monthly IVA. Methods: We conducted a prospective, interventional study. Fifty-eight treatment-naïve patients with tAMD were randomly assigned to the PRN (30 patients) or the bimonthly (28 patients) treatment group. Both groups initially received 3 monthly IVA. Visual acuity, central macular retinal thickness (CRT), and central choroidal thickness (CCT) were evaluated at 12 months. Subanalysis was performed to identify factors associated with the best-corrected visual acuity (BCVA). Results: BCVA was significantly improved only in the bimonthly group at 12 months. CRT and CCT were significantly decreased in both groups. Subanalysis showed that the only factor associated with BCVA improvement at 12 months was the existence of pigment epithelial detachment at baseline. Conclusions: BCVA showed significant improvement only in the bimonthly group but not in the PRN group at 12 months.
Bayesian quantile regression for ordinal longitudinal data
Creators: name: Alhamzawi, Rahim
name: Haithem Taha Mohammad Ali
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Since the pioneering work by Koenker and Bassett [27], quantile regression models and its applications have become increasingly popular and important for research in many areas. In this paper, a random effects ordinal quantile regression model is proposed for analysis of longitudinal data with ordinal outcome of interest. An efficient Gibbs sampling algorithm was derived for fitting the model to the data based on a location-scale mixture representation of the skewed double-exponential distribution. The proposed approach is illustrated using simulated data and a real data example. This is the first work to discuss quantile regression for analysis of longitudinal data with ordinal outcome.
Supplementary Information (SI) from Mapping poverty using mobile phone and satellite data
Creators: name: Steele, Jessica
name: Sundsøy, Pål Roe
name: Pezzulo, Carla
name: A. Alegana, Victor
name: Bird, Tomas J.
name: Blumenstock, Joshua
name: Bjelland, Johannes
name: Engø-Monsen, Kenth
name: de Montjoye, Yves-Alexandre
name: Iqbal, Asif M.
name: Hadiuzzaman, Khandakar N.
name: Lu, Xin
name: Wetter, Erik
name: J. Tatem, Andrew
name: Bengtsson, Linus
Publisher: name: The Royal Society
Year: 2017

description: The supplementary information provides a description for all input data used in this study, including their sources, units of measurement, and spatial resolutions. All methodologies used to process and analyse these data are fully referenced and detailed. Model specifications and additional poverty maps are also included with tables comparing covariates for national, urban, and rural models, as well as results comparing BGMs run with and without a spatial component.
ПРОБЛЕМА РАЦИОНАЛЬНОГО РАСПРЕДЕЛЕНИЯ И ИСПОЛЬЗОВАНИЯ ВОДНЫХ РЕСУРСОВ ТРАНСГРАНИЧНЫХ ТЕРРИТОРИЙ
Creators: name: Л. Г. Матвеева
name: О. А. Чернова
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: Водные ресурсы
трансграничные территории
водные бассейны
регионы
рациональное распределение водных ресурсов.

description: В рамках реализуемой в настоящее время в России парадигмы ресурсосбережения и ресурсоэффективности, в том числе в отношении потребления базовых системообразующих ресурсов, применение экономических методов управления ограниченными водными ресурсами трансграничных территорий (расположенных в границах одного водного бассейна) не только эффективно, как и для других природных ресурсов, но имеет принципиальное значение ввиду особой остроты проблемы достижения баланса интересов потребителей. Последнее объясняется объективно существующей дифференциацией трансграничных территорий по показателям состояния и использования их природного и других видов потенциала, а также проводимой социально-экономической политикой и политикой водопотребления. В силу этого решение проблемы рационального распределения ресурсов водного бассейна между трансграничными территориями лежит сразу в нескольких плоскостях – экономической, социальной, природоохранной (экологической) и политической и может быть найдено с использованием адаптивного экономического инструментария управления.
АКТУАЛЬНЫЕ ПРОБЛЕМЫ ОБЕСПЕЧЕНИЯ ИНФОРМАЦИОННОЙ БЕЗОПАСНОСТИ СИСТЕМ ЭЛЕКТРОН- НОГО ДОКУМЕНТООБОРОТА В РАМКАХ ЦИФРОВОЙ ТРАНСФОРМАЦИИ
Creators: name: М. А. Мирошниченко
name: А. А. Бондаренко
name: Е. В. Пиналова
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: защита информации
информационная безопасность
система электронного документооборота
цифровые технологии

description: В статье рассматриваются особенности функционирования системы обеспечения информационной безопасности в современной организации. Внедрение современных цифровых технологий во многие отрасли экономики требует применения инновационных подходов по обеспечению полноценной защиты ценных информационных массивов. Раскрывается сущность понятия информационной безопасности и комплексного подхода к защите информации от несанкционированного доступа. Приводится обоснование необходимости формирования защищенного электронного документооборота в условиях цифровой трансформации, аргументированы направления обеспечения информационной безопасности. Обеспечение комплексной информационной безопасности подразумевает осуществление непрерывного контроля и мгновенное реагирования в режиме реального времени за событиями в области кибербезопасности на протяжении полного жизненного цикла хранения и обработки документной информации. Подобные меры необходимы для минимизации рисков утечки конфиденциальных данных и связанных с ними убытками для компании.
СИСТЕМА УПРАВЛЕНИЯ ЗНАНИЯМИ КАК ОСНОВА ЭФФЕКТИВНОЙ ДЕЯТЕЛЬНОСТИ ЦЕНТРА ГОСУДАРСТВЕННЫХ И МУНИЦИПАЛЬНЫХ УСЛУГ «МОИ ДОКУМЕНТЫ»
Creators: name: М. А. Мирошниченко
name: Т. С. Зотова
name: И. А. Леготин
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: государственные услуги
знания
интеллектуальный капитал
потенциал
цифровая экономика
человеческий капитал.

description: В статье рассмотрена взаимосвязь человеческого капитала и системы управления знаниями. Человеческий капитал – это один из главных факторов развития организации и общества. Так как благодаря ему совершенствуются внутренние процессы, внедряются инновации, оптимизируется структура. Представлен обзор элементов и структуры системы управления знаниями. Аргументировано влияние внутренних качеств человека на формирование корпоративной культуры. На примере центра государственных и муниципальных услуг «Мои документы» рассмотрена структура системы управления знаниями. Описана организация обучения сотрудников, ее необходимые элементы, функции руководителей отделения и такой феномен как институт наставничества. На основе новых возможностей программы «Цифровая экономика» сделан прогноз к 2024 году результатов ее исполнения. Появится возможность реализации основной идеи цифровой экономики для граждан  сделать государство более эффективным и менее заметным, повысить уровень общественной безопасности, проводить время с близкими, не тратя время на государственные услуги.
Diterpenoid alkaloids from the root of Aconitum sinchiangense W. T. Wang with their antitumor and antibacterial activities
Creators: name: Liang, Xiaoxia
name: Chen, Lan
name: Song, Lei
name: Fei, Wenbo
name: He, Min
name: He, Changliang
name: Yin, Zhongqiong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: A phytochemical study of the root barks of Aconitum sinchiangense W. T. Wang, a traditional Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new C19-diterpenoid alkaloid, sinchiangensine A (1), whose structure was determined by spectral methods including 2D NMR. Additionally, sinchiangensine A and its known analogue 3 were first reported as potential antitumor and antibacterial diterpenoid alkaloids, which showed significant antitumor activities against tumour cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC50 comparable to cisplatin, and significant antibacterial activities against Staphylococcus aureus ATCC-25923 with MIC value of 0.147 and 0.144 μmol/mL, respectively.
A review of existing and emerging digital technologies to combat the global trade in fake medicines
Creators: name: Mackey, Tim K.
name: Gaurvika Nayyar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Introduction: The globalization of the pharmaceutical supply chain has introduced new challenges, chief among them, fighting the international criminal trade in fake medicines. As the manufacture, supply, and distribution of drugs becomes more complex, so does the need for innovative technology-based solutions to protect patients globally. Areas covered: We conducted a multidisciplinary review of the science/health, information technology, computer science, and general academic literature with the aim of identifying cutting-edge existing and emerging ‘digital’ solutions to combat fake medicines. Our review identified five distinct categories of technology including mobile, radio frequency identification, advanced computational methods, online verification, and blockchain technology. Expert opinion: Digital fake medicine solutions are unifying platforms that integrate different types of anti-counterfeiting technologies as complementary solutions, improve information sharing and data collection, and are designed to overcome existing barriers of adoption and implementation. Investment in this next generation technology is essential to ensure the future security and integrity of the global drug supply chain.
ИССЛЕДОВАНИЕ РОЛИ УПРАВЛЕНИЯ ЧЕЛОВЕЧЕСКИМ КАПИТАЛОМ В РАМКАХ ОБЕСПЕЧЕНИЯ МЕНЕДЖМЕНТА КАЧЕСТВА ОРГАНИЗАЦИИ В УСЛОВИЯХ ЦИФРОВОЙ ЭКОНОМИКИ И БЕРЕЖЛИВЫХ ИННОВАЦИЙ
Creators: name: М. А. Мирошниченко
name: А. В. Ковтун
name: К. А. Кузнецова
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: бережливые инновации
конкурентоспособность
менеджмент качества
цифровизация
человеческий капитал.

description: В статье аргументировано, что актуальным направлением в области менеджмента качества является развитие человеческого капитала организации. Доказано, что качество человеческого капитала определяет не только качество внутренних процессов компании, но и ее успешное функционирование в целом, сохранение конкурентоспособности и создание уникальных конкурентных преимуществ. Человеческие потенциал определяет инновационную активность компании, а бережливые инновации рассматриваются как инновационное решение, обладающее высокой полезностью и создающее большую коммерческую и социальную ценность для компании. Бережливые инновации и рациональное управление изменениями нацелены на создание самообучающейся организации, достигающей состояния стабильного процветания в динамичном и сложном внешнем мире современности за счет постоянных экспериментов, импровизаций и открытий. Роль человеческого капитала в менеджменте качества очень высока, однако сам процесс управления персоналом требует от менеджеров соблюдения определенных условий и внедрение новейших технологий, в том числе бережливых инноваций в условиях развития цифровой экономики.
РАЗВИТИЕ ПРЕДПРИНИМАТЕЛЬСКИХ СПОСОБНОСТЕЙ НА ОСНОВЕ ИЗУЧЕНИЯ СПЕЦИФИКИ ФЕНОМЕНА ПРЕДПРИНИМАТЕЛЬСТВА
Creators: name: И. В. Мишурова
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: методы подготовки теста; оценка предрасположенности к предпринимательской деятельности

description: Одним из актуальных направлений поддержки и развития предпринимательства является его популяризация. В рамках реализации национального проекта «Малое и среднее предпринимательство и поддержка индивидуальной предпринимательской инициативы» реализовано крупномасштабное тестирование потенциальных и действующих предпринимателей во всех регионах России. На основе анализа отечественного и зарубежного опыта была автором разработана методика оценка предрасположенности к предпринимательской деятельности для тестирования потенциальных и действующих предпринимателей в Ростовской области. В результате исследования было принято решение о тестировании 10 качеств, необходимых предпринимателям: Лидерство; Готовность к риску; Высокая работоспособность; Независимость; Гибкость, адаптивность; Стрессоустойчивость, упорство; Коммуникативные навыки; Инициативность; Мотивация к созданию бизнеса; Благоприятная локальная социальная среда. Пробное тестирование с помощью вопросника, содержащего 30 «закрытых» вопросов, показало достаточно высокую достоверность результатов тестировании. Это позволило протестировать более 15 тысяч потенциальных и действующих предпринимателей и сформулировать предложения по формированию предпринимательских компетенций с использованием технологий бизнесобразования.
Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease
Creators: name: Small, David M.
name: Beetham, Kassia S.
name: Howden, Erin J.
name: Briskey, David R.
name: Johnson, David W.
name: M. Isbel, Nicole
name: Gobe, Glenda C.
name: S. Coombes, Jeff
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology

description: Objectives: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients. Methods: A total of 136 stage 3–4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months. Results: There were no significant differences between groups at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (p = 0.88), GPX (p = 0.87), or TAC (p = 0.56). Patients identified as having high IsoP at baseline (>250 pg/mL) had a greater decrease in IsoP with lifestyle intervention compared to standard care; however, the difference was not statistically significant (p = 0.06). There was no difference in the change in kidney function (eGFR) between standard care and lifestyle intervention (p = 0.33). Discussion: Exercise and lifestyle modification in stage 3–4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care.
ВЛИЯНИЕ ЦИФРОВИЗАЦИИ НА ЭКСПОРТ УСЛУГ
Creators: name: М. А. Морозов
name: М. М. Морозов
Publisher: name: Вестник Академии знаний
Year: 2020
Subjects: экспорт услуг
несырьевой экспорт
глобальная цифровизация
цифровые технологии
конкурентоспособность.

description: Экспортная деятельность является одним из важных показателей конкурентоспособности национальной экономики. В последние годы Российская Федерация уделяет большое внимание развитию экспорта в рамках реализации национального проекта «Международная кооперация и экспорт». Особую значимость приобретает несырьевой экспорт, который также развивается в рамках федерального проекта «Экспорт услуг». Экспорт услуг имеет хорошие перспективы развития в связи с тем, что он может использовать современные цифровые технологии, которые уже сейчас показывают высокую эффективность. В статье рассмотрены современные цифровые технологии, являющиеся базой для создания цифровых площадок экспорта услуг. Изучены возможности наиболее известных цифровых платформ для организации экспорта услуг, рассмотрены перспективы развития экспорта услуг на базе цифровых технологий.
Solvent effect in polymer analysis by MALDI-TOF mass spectrometry
Creators: name: Wu, Ting
name: Zhang, Chuanjing
name: Ren, Hongxin
name: Xi, Yidan
name: Du, Yiping
name: Peng, Yaxin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified

description: Solvent effect is one of the important factors in sample preparation which may affect matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra of synthetic polymers. MALDI imaging, a useful imaging tool for discovering biomarkers in tissues, is applied here for better comprehension of solvent effect in polymer analysis by MALDI-TOF mass spectrometry. Nylon-6 was chosen as a model polymer for the study of solvent effect. Its MALDI mass spectra in different solvents were performed. MALDI imaging analysis was performed for studying the incorporation of analytes into matrix crystals in different solvent combinations. Specifically, the colocalization of matrix and analyte was obtained through Pearson’s correlation (PC) coefficient analysis of their MALDI images. The results demonstrated that satisfactory spectra were obtained in higher PC value conditions. PC decreased along with an increase in the ratio of poor solvent, which suggested that we should minimize the poor solvent ratio to obtain better MALDI spectra.
Vers l'institutionnalisation de la solidarité à Madagascar. Un regard sur le "Conseil du Fampihavanana malagasy" (CFM)
Creators: name: Kneitz, Peter
Publisher: name: Zenodo
Year: 2020
Subjects: Madagascar, solidarity, fihavanana, Conseil de Fampihavanana Malagasy, CFM, politics

description: Since 2013 a new constitutional institution exists in Madagascar. First named “Malagasy Reconciliation Committee” (CRM) or “Filankevitry ny Fampihavanana Malagasy” (FFM), it was recently renamed as part of a restructuring and is now called “Conseil du Fampihavanana Malgasy” (CFM) . The birth of this institution is linked, on the one hand, to the political events since 2009 in Madagascar, and to the structures of reconciliation on the African continent, where they were created after serious crises in a number of countries. At the same time, it seems the expression of a very long and specifically Malagasy development, linked to the idea of fihavanana (solidarity), regularly seen as a central norm by the population and by the actors of the Big Island. With my speech, I would first of all contextualize the CFM by linking it with the history of solidarity in Madagascar, and then develop the institution of the CFM more precisely, i.e. describe their task, their work and then the current changes underway.
Constrained multi-objective optimization using constrained non-dominated sorting combined with an improved hybrid multi-objective evolutionary algorithm
Creators: name: Ning, Weikang
name: Guo, Baolong
name: Yan, Yunyi
name: Wu, Xianxiang
name: Wu, Jinfu
name: Zhao, Dan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Constrained multi-objective optimization problems (cMOPs) are complex because the optimizer should balance not only between exploration and exploitation, but also between feasibility and optimality. This article suggests a parameter-free constraint handling approach called constrained non-dominated sorting (CNS). In CNS, each solution in a population is assigned a constrained non-dominated rank based on its constraint violation degree and Pareto rank. An improved hybrid multi-objective optimization algorithm called cMOEA/H for solving cMOPs is proposed. Additionally, a dynamic resource allocation mechanism is adopted by cMOEA/H to spare more computational efforts for those relatively hard sub-problems. cMOEA/H is first compared with the baseline algorithm using an existing constraint handling mechanism, verifying the advantages of the proposed constraint handling mechanism. Then cMOEA/H is compared with some classic constrained multi-objective optimizers, experimental results indicating that cMOEA/H could be a competitive alternative for solving cMOPs. Finally, the characteristics of cMOEA/H are studied.
A new dimeric stilbene from the lianas of Gnetum parvifolium
Creators: name: Tian, Li-Wen
name: Lv, Jun-Jiang
name: Liu, Yao
name: Song, Lu-Yao
name: Hou, Lian-Bing
name: Zhong, Cheng
name: Xie, Yang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A new dimeric stilbene, gnetifolin P (1), was isolated from the lianas of Gnetum parvifolium, together with seven known compounds 2–8. The structure of compound 1 was determined by extensive NMR and HRESIMS data analyses, and quantum chemical calculations. All the compounds were evaluated for their anti-inflammatory activity. Compounds 1 and 6 inhibited the expression of IL-1β on LPS induced THP-1 cells with the inhibition rate of 35.78 and 64.67%, respectively, at concentration of 25 μg/mL.
Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro
Creators: name: Lu, Ying-Yuan
name: Cheng, Hai-Xu
name: Wang, Xin
name: Wang, Xiao-Wei
name: Liu, Jun-Yi
name: Li, Pu
name: Lou, Ya-Qing
name: Li, Jun
name: Lu, Chuang
name: Zhang, Guo-Liang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: 1. The aim of this study was to identify the hepatic metabolic enzymes, which involved in the biotransformation of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) in rat and human in vitro. 2. The parent drug of W-1 was incubated with rat liver microsomes (RLMs) or recombinant CYPs (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, and CYP3A5, respectively) in the presence or absence of nicotinamide adeninedinucleotide phosphate (NADPH)-regenerating system. The metabolites of W-1 were analyzed with liquid chromatography-ion trap-time of flight-mass spectrometry (LC-IT-TOF-MS). 3. The parent drug of W-1 was metabolized in a NADPH-dependent manner in RLMs. The kinetic parameters of prototype W-1 including Km, Vmax, and CLint were 2.3 μM, 3.3 nmol/min/mg protein, and 1.4 mL/min/mg protein, respectively. Two metabolites M1 and M2 were observed in shorter retention times (2.988 and 3.188 min) with a higher molecular ion at m/z 463.0160 (both M1 and M2) than that of the W-1 parent drug (6.158 min with m/z 447.0218). The CYP selective inhibition and recombinant enzymes also showed that two hydroxyl metabolites M1 and M2 are mainly mediated by CYP2C19 and CYP3A4. 4. The identification of CYPs involved in W-1 biotransformation is important to understand and minimize, if possible, the potential of drug–drug interactions.
Evaluation of genome-wide susceptibility loci for high myopia in a Han Chinese population
Creators: name: Li, Fang
name: Ye, Zimeng
name: Zhai, Yaru
name: Gong, Bo
name: Jiang, Lingxi
name: Wu, Haiyan
name: Lin, Ying
name: Wan, Ling
name: Yang, Zhenglin
name: Shi, Yi
name: Wu, Zhengzheng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Purpose: High myopia (HM) is a common cause of visual impairment worldwide. Previous genome-wide association studies have reported that seven single nucleotide polymorphisms (SNPs), including rs1254319, rs3138144, rs12205363, rs17648524, rs7829127, rs1656404, and rs7084402, are associated with HM in Caucasians. The aim of this study was to investigate the association of these SNPs in Han Chinese. Methods: SNPs were genotyped by SNaPshot method in a Chinese cohort composed of 830 HM patients and 1140 controls. Results: Rs17648524 (C/G) and rs7084402 (A/G) were significantly associated with HM (p = 3.0 × 10−3, OR = 0.43; p = 3.7 × 10−2, OR = 1.25, respectively). The association of rs17648524 was also observed under the heterozygous model (CG vs. GG, p = 7.0 × 10−3, OR = 0.43) and the dominant model (CC + CG vs. GG, p = 4.0 × 10−3, OR = 0.42). The association of rs7084402 was found under the homozygous model (GG vs. AA, p = 4.0 × 10−2, OR = 1.56) and the dominant model (GG+ AG vs. AA, p = 3.8 × 10−2, OR = 1.41). Another SNP, rs7829127 (A/G), was found to be significantly associated with HM under the heterozygous model (AG vs. AA, p = 4.6 × 10−2, OR = 0.67). Furthermore, the associations of rs17648524 and rs7084402 with HM were gender-specific, with significance observed only in females but not in males. As for the other four SNPs, no associations were detected under these genetic models. Conclusions: Our findings suggested rs17648524 (intronic RBFOX1 gene) and rs7084402 (7.5kb 5′ of the BICC1 gene) showed gender-specific associations with high myopia in the Han Chinese.
Mononuclear piano-stool iron 2-ethynylbenzo[b]thiophene complex: Crystal structure and reversible oxidation studied by spectro-electrochemical and DFT methods
Creators: name: Ou, Ya-Ping
name: Zhang, Jing
name: Kuang, Daizhi
name: Zhang, Fuxing
name: Yu, Jiangxi
name: Zhu, Xiaoming
name: Liu, Sheng Hua
name: Hartl, František
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: A mononuclear iron complex with 2-ethynylbenzo[b]thiophene C-coordinated to the (η5-Cp*)(η2-dppe)Fe (Cp* = pentamethylcyclopentadienyl, dppe = 1,2-diphenylphosphinoethane) framework (1) was prepared and characterized by 1H-NMR, elemental analysis and single crystal X-ray diffraction. The redox behavior of 1 was investigated by voltammetric methods and anodic spectroelectrochemistry in the UV-vis-NIR-IR region and compared with reference complexes including 2-ferrocenylbenzo[b]thiophene (2) and the 2-ethynylpyridine derivative of 1. The spin density distribution along the linear molecular backbone in 1+ was analyzed by DFT (BLYP35) and TDDFT calculations of a truncated model complex. The combined experimental and theoretical results revealed an important role of the ethynylene linker in determining the redox properties of this family of complexes and participation of the 2-ethynylbenzo[b]thiophene framework in the largely iron-based anodic electron transfer.
Snow-glide model in LTER Research Site Stubai Valley, Austria
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: The aim of the study was to identify the most important drivers for snow-gliding and to establish a spatial snow glide model (SSGM). The snow-glide measurements were conducted for the Kaserstattalm within the LTER Research Site Stubai Valley. The dataset provides information about the influence variables on snow gliding such as: slope, aspect, tree precence and density, surface rougness, winter precipitation, mean winter temperature,... The measurements were conducted during winter in the period 1997-2002. The dataset also contains a shapefile representing the distribution of the 65 measurement points.
Deposition NH4+ NO3 Renon BOL1
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: The site is located in the Central Alps ca. 12 km due north of Bozen/Bolzano at an altitude of 1.770 m. It consists of a monitoring open-field station situated in a meadow on a W-facing slope open to the westerlies, so that transboundary airborne pollutants (eg. air chemical composition: O3, NO, NO2, depositions, etc.) can be monitored. Dataset provides bulk deposition values from 1985 to 2017.
A implantação do programa de qualidade 5S em uma distribuidora de bebidas no município de Marabá-PA
Creators: name: Santos, Tiago
name: Géssica Santos
name: Lourinho, Jade
name: Corrêa, Fernanda
Publisher: name: figshare
Year: 2017
Subjects: subject: 91301 Acoustics and Noise Control (excl. Architectural Acoustics)
subject: FOS: Mechanical engineering
subject: 91503 Engineering Practice
subject: FOS: Other engineering and technologies

description: Esse artigo foi realizado em uma microempresa, do segmento de distribuição de bebidas, localizadas na região sudeste do Pará no município de Marabá. O estudo tem o propósito de apresentar os benefícios da utilização do programa 5S para a melhoria da qualidade no negócio, pois a ferramenta tem uma grande importância no processo de implementação de um programa de qualidade total. O trabalho caracteriza-se como um estudo exploratório in loco, e com a análise dos dados houve um diagnóstico claro, da situação do empreendimento estudado, evidenciando a necessidade da utilização da metodologia 5S que promove a competitividade no mercado otimizando os lucros e consolidando a estratégia do microempreendimento.
Une analyse dynamique des interactions entre acteurs portuaires et leurs effets sur l’efficience d’un port pétrolier
Creators: name: Belaid, Emna
name: Rigo, Philippe
name: Cools, Mario
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Le port est une entité hétérogène qui regroupe un ensemble d’acteurs dont les objectifs sont parfois contradictoires. L’analyse de leurs interactions permet de comprendre le mécanisme qui régit la gestion portuaire. Ce mécanisme influence la performance du port. Dans cet article, nous analysons l’efficience portuaire selon un modèle dynamique. Ce dernier est basé sur un cadre conceptuel établi selon une analyse systémique. Les simulations effectuées montrent que les paramètres « vitesse de chargement » et « dimension du connecteur » sont les paramètres les plus influents. L’investissement dans des nouvelles installations pour le port de La Skhira (Sfax, Tunisie) est notre principale recommandation.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
title: Interventions non-pharmacologiques permettant la diminution de la douleur et de l’anxiété chez les patients grands brûlés
title: Interventions non-pharmacologiques permettant la diminution de la douleur et de l’anxiété chez les patients grands brûlés
titleType: AlternativeTitle
Creators: name: Bonnefoy, Marion
name: Repond, Estelle
Publisher: name: Unknown
Year: 0
Subjects: subject: Grands brulés
subject: Douleur
subject: Interventions non pharmacologiques

description: Dans le monde, 11 millions de personnes sont victimes de brûlures dont 16’700 en Suisse. Parmi eux, les grands brûlés sont les plus gravement touchés. En plus des conséquences biopsychosociales des brûlures, les patients sont confrontés aux symptômes de la douleur et l’anxiété, notamment lors de la dispensation des soins. Il semble donc pertinent pour une pratique des soins infirmiers de qualité de proposer et réaliser des interventions non-pharmacologiques permettant la diminution de ces deux symptômes.
Mononuclear piano-stool iron 2-ethynylbenzo[b]thiophene complex: crystal structure and reversible oxidation studied by spectro-electrochemical and DFT methods
Creators: name: Ou, Ya-Ping
name: Zhang, Jing
name: Kuang, Daizhi
name: Zhang, Fuxing
name: Yu, Jiangxi
name: Zhu, Xiaoming
name: Liu, Sheng Hua
name: Hartl, František
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: A mononuclear iron complex with 2-ethynylbenzo[b]thiophene C-coordinated to the (η5-Cp*)(η2-dppe)Fe (Cp* = pentamethylcyclopentadienyl, dppe = 1,2-diphenylphosphinoethane) framework (1) was prepared and characterized by 1H NMR, elemental analysis, and single crystal X-ray diffraction. The redox behavior of 1 was investigated by voltammetric methods and anodic spectroelectrochemistry in the UV–vis-NIR-IR region and compared with reference complexes including 2-ferrocenylbenzo[b]thiophene (2) and the 2-ethynylpyridine derivative of 1. The spin density distribution along the linear molecular backbone in 1+ was analyzed by DFT (BLYP35) and TDDFT calculations of a truncated model complex. The combined experimental and theoretical results revealed an important role of the ethynylene linker in determining the redox properties of this family of complexes and participation of the 2-ethynylbenzo[b]thiophene framework in the largely iron-based anodic electron transfer.
Aplicação do estudo de tempos para a determinação da capacidade produtiva em uma pastelaria no município de Marabá - PA
Creators: name: Santos, Tiago
name: Alves, Lucas
Publisher: name: figshare
Year: 2017
Subjects: subject: 99902 Engineering Instrumentation
subject: FOS: Other engineering and technologies
subject: 99999 Engineering not elsewhere classified

description: O artigo apresenta um estudo de caso realizado em uma pastelaria localizada no município de Marabá no suldeste do Pará, onde o objetivo é identificar a capacidade produtiva aplicando-se ferramentas da engenharia de métodos para o encontro de melhorias em parte do tempo de execuções das operações. Para tal, foi realizada uma análise teórica e através dos calculados do tempo normal, do tempo padrão, da capacidade produtiva, obtevese resultados que contribui de grande forma para um aperfeiçoamento da produtividade do micro empreendimento.