cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of welfare cheque issue days on a service for those intoxicated in public
Creators: name: Li, Xin
name: Sun, Huiying
name: Marsh, David C.
name: Anis, Aslam H. (Aslam Hayat), 1959-
Publisher: name: BioMed Central
Year: 2015

description: In British Columbia (BC), the Ministry of Human Resources issues welfare cheques to eligible recipients monthly on the last Wednesday of each month. Previous studies have indicated that there are significant increases in hospital admission, ED admission, 911 calls and deaths shortly after the distribution of the monthly welfare cheques. The objective of this analysis was to rigorously examine the impact of welfare cheque issue dates on admission to the Sobering Unit (SU), a service for the publicly intoxicated, in Vancouver, Canada. Data on 1234 consecutive admissions to the SU over a 7-month period were assessed, and the average number of daily admissions on each of the 7 days of the welfare cheque issue week and similar weekdays in other weeks were compared. A Wilcoxon rank-sum test was performed for the comparisons. Our results showed that there were significant increases in the number of admissions on the 3 days starting with "Welfare Wednesday" compared to the similar weekdays in other weeks (Welfare Wednesday vs. other Wednesdays: 8.7 vs. 5.1, p = 0.02; Welfare Thursdays vs. other Thursdays: 9.6 vs. 5.3, p = 0.02; Welfare Fridays vs. other Fridays: 8.6 vs. 5.7, p = 0.04). The demonstrated impact of welfare cheque issue dates is an important consideration for the re-design, staffing and resource allocation of services for withdrawal management and potentially for other services offered to this population.
The effect of a rapid increase in irradiance on domoic acid production and nitrate uptake by Pseudo-nitzschia multiseries
Creators: name: Thessen, Anne
Publisher: name: figshare
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cell Biology

description: This is an unpublished chapter from my thesis.
Knowing is not enough: Organizational Capacity of Developing Countries' Health Professional Associations to Utilize Research
Creators: name: Hamel, Nadia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Public Health.
subject: Sociology, Organizational.
subject: Health Sciences, Health Care Management.

description: The need for effective interfaces to translate research into policy-making is one of the most important challenges in addressing population health in low- and middle-income countries (LMICs). The capacity to acquire, manage and apply research findings in programs' decision-making is essential for all health systems actors, including health professional associations in their roles as civil society organizations. The purpose of this dissertation was to understand better how organizational capacity to utilize research influences the knowledge translation performance of LMICs health professional associations. The research used a mixed methods exploratory sequential design. Phase one was an interview-based case study of the Burkina Faso Public Health Association. Phase two consisted of a survey of all nineteen LMICs health professional associations in a CIDA-funded partnership program focussing on institutional capacity strengthening. Triangulation of data was carried out, applying the concept of organizational "absorptive capacity" to shape the foundations of a framework. The qualitative inquiry identified factors influencing the capacity to utilize research, such as the organizational motivation to utilize research, triggers that persuade an association to invest in this capacity, and the processes to exploit and present the research findings in a useful way. The quantitative inquiry revealed that the utilization of research findings is a priority for these associations. Key organizational elements that underlie associations' organizational capacities to utilize research were identified. For example, half have used evidence from scientific journals and over a third have developed arrangements with researchers. However, associations' capacities are jeopardized by scarcity of resources to ensure that research is accessed, adapted and applied, and to recruit staff for knowledge translation strategies. Finally, the potential relationships among identified determinants were integrated in an operational framework capturing the organizational capacity to utilize research (OCUR). This multi-method study was the first to map institutional capacity needs for research utilization of LMICs health professional associations. The framework provides a guide to investigate associations' organizational capacity to utilize research and can aid in tailoring capacity-building strategies to strengthen associations' knowledge translation potential.
The Fring coin hoard
Creators: name: Gurney, David
name: Chadburn, Amanda
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 41 (2), 218-225
description: A partially-dispersed hoard of 153 silver Iron Age coins of the Iceni tribe were recovered, together with fragments of pottery and textile remains. It is likely that the hoard had originally been contained in the pottery vessel which had been sealed by a piece of cloth, which is described in `The textile remains' by Man-Yee Liu & Elisabeth Crowfoot (220). The deposition of the hoard is dated to the mid first century AD.
Fall-out of a New Political Regime in India
Creators: name: Rothermund, Dietmar
Publisher: name: Asien
Year: 2021

description: Eine "rechte" Koalition geführt von der Bharatiya Janata Party (BJP) hat das "Congress System" abgelöst, das darin bestand, daft sich eine "Zentrumspartei" durch die Polarisation von rechter und linker Opposition an der Macht erhielt. Wahlallianzen der BJP haben regionalen Parteien zu Sitzen verholfen, die früher im Schatten der nationalen Parteien standen. So verschaffte sich die BJP Koalitionspartner. Die Wähler haben der BJP kein überzeugendes Mandat erteilt, dennoch führte sie ihr Programm durch, zu dem die Atomtests gehörten, die dann in der Bevölkerung breite Zustimmung fanden. Die BJP fühlt sich so dazu ermutigt, eine sehr selbstbewußte Außenpolitik zu betreiben. Dazu gehört auch die Betonung der wirtschaftlicnen Eigenständigkeit (Swadeshi). Der am 1.6.1998 vorgelegte Staatshaushalt zeigt kein Entgegenkommen gegenüber ausländischen Investoren. Den angekündigten amerikanischen Sanktionen wurde mit einer Rücklage begegnet und die Verteidigungsausgaben um 14 Prozent erhöht.
description: Asien, Nr. 68 (1998): ASIEN (Juli)
Application of a hybrid wavelet feature selection method in the design of a self-paced brain interface system
Creators: name: Fatourechi, Mehrdad
name: Birch, Gary E.
name: Ward, Rabab Kreidieh
Publisher: name: BioMed Central
Year: 2016

description: Background: Recently, successful applications of the discrete wavelet transform have been reported in brain interface (BI) systems with one or two EEG channels. For a multi-channel BI system, however, the high dimensionality of the generated wavelet features space poses a challenging problem. Methods: In this paper, a feature selection method that effectively reduces the dimensionality of the feature space of a multi-channel, self-paced BI system is proposed. The proposed method uses a two-stage feature selection scheme to select the most suitable movement-related potential features from the feature space. The first stage employs mutual information to filter out the least discriminant features, resulting in a reduced feature space. Then a genetic algorithm is applied to the reduced feature space to further reduce its dimensionality and select the best set of features. Results: An offline analysis of the EEG signals (18 bipolar EEG channels) of four able-bodied subjects showed that the proposed method acquires low false positive rates at a reasonably high true positive rate. The results also show that features selected from different channels varied considerably from one subject to another. Conclusion: The proposed hybrid method effectively reduces the high dimensionality of the feature space. The variability in features among subjects indicates that a user-customized BI system needs to be developed for individual users.
Identification of Candidate Exposure Biomarkers for Toxicants in Complex Environmental Matrices
Creators: name: Osika, Natalie Ann
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Environmental Health.
subject: Chemistry, Analytical.

description: The term "biomarker" refers to an indicator employed to monitor the interactions between a xenobiotic and an individual, provide information of an individual's biologic state, or refer to an individual's susceptibility to a xenobiotic, condition or disease. They are currently employed to assess exposure to, or effects from, environmental toxicants. It is important to have biomarkers that can accurately and precisely assess complex mixture exposures, since environmental exposures to single substances rarely occur outside the laboratory setting, and complex exposures are often associated with specific occupational or environmental settings. This project employed microarray technology and subsequent bioinformatic analyses to identify candidate biomarkers of in vitro exposure to coal tar extract. Murine pulmonary epithelial cells were exposed to coal tar extract and gene expression was assessed using microarrays. The results showed that expression of genes involved in steroidogenesis, cytokine-cytokine interaction, angiogenesis, as well as several genes that code for secreted proteins, were altered by coal tar exposure. The entire work constitutes the initial stages of a project that will ultimately identify gene expression and secretome profiles that are specific to coal tar exposure.
Using Framingham for primary prevention cardiovascular risk assessment
Creators: name: Therapeutics Initiative (University Of British Columbia)
Publisher: name: The University of British Columbia
Year: 2023

description: Therapeutics Letter 63 looks at the use of Framingham for primary prevention cardiovascular risk assessment. As with most calculators, family history and weight are not variables and so clinicians must use clinical judgment when these factors are considered important. Conclusions: If you use Framingham to calculate risk, make sure you know what endpoints are included and over what period of time. Framingham risk assessment has a number of limitations and there is a lack of evidence of its impact on prescribing practice or health outcomes. Risk assessment needs to be studied in RCTs as compared to standard care to determine the impact on prescribing in patient populations with different risks at baseline and to see if patients presented with risk estimates feel more informed and make different treatment decisions.
Applying beetroot as food ingredient in ice-cream production
Creators: name: Evstigneeva, T.
name: Iakovchenko, N.
name: Kuzmicheva, N.
name: Skvortsova, N.
Publisher: name: Agronomy Research
Year: 2020
Subjects: ise cream
beetroot puree
betanines
article

description: The development of new food products with functional ingredients of plant origin is highly promising and relevant direction in food industry. Assortment of products, including ice cream is constantly expanding due to the introduction of various plant ingredients into its composition, enriching the product with health beneficial nutrients. In this study, beetroot (Beta vulgaris) was selected as a plant component for ice cream production. The roots of common beets contain many useful inorganic and organic substances, such as carbohydrates, proteins, organic acids, mineral salts, betalaines, vitamins, folic acid and betaine. The influence of different thermal treatment techniques of beetroots on the content of dry substances and organoleptic properties of beetroot puree have been compared and analyzed. The heat exposure technique recommended for beetroots is microwave processing for 9 minutes at a power of 800 watts. This method of heat treatment ensures the culinary readiness of vegetable raw materials while preserving dry substances in it, including betanine. The effect of the beetroot puree dose on the formation of the ice cream quality was studied. The recommended dose of the beetroot puree was established as 20%.
AXBOROT-KUTUBXONA XIZMATIDA FORUMLARNI TASHKIL ETISH.
Creators: name: Mannonov, Yusup
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada virtual ma’lumot xizmati,  virtual kutubxona, elektron kutubxona,  Axborot-kutubxona xizmatida  forumlarni tashkil etish usul va vositalari tahlili,  forumlarning turlari, forumlarda ishtirok etish tartibi haqida fikr - mulohazalar bayon etilgan.
Deutsch-Koreanische Industrie- und Handelskammer (Hrsg.): Partnerland Korea 1998. Doing Business with Confucius
Creators: name: Schucher, Günter
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 67 (1998): ASIEN (April)
Herrmann-Pillath, Carsten; Michael Lackner (Hrsg.): Länderbericht China. Politik, Wirtschaft und Gesellschaft im chinesischen Kulturraum
Creators: name: Kotzel, Uwe
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 67 (1998): ASIEN (April)
Closed to reason: time for accountability for the International Narcotic Control Board
Creators: name: Small, Dan
name: Drucker, Ernest
Publisher: name: BioMed Central
Year: 2015

description: For more than two decades, the International Narcotic Control Board (INCB) has tried to stop harm reduction and its HIV prevention programs. This posture is based on a fundamental misunderstanding of their responsibilities and of drug addiction itself – i.e. as a public health and clinical care matter made criminal by decree. A recent focal point for the Board's action has been rejecting the use of supervised injection facilities to reduce morbidity and mortality of drug injectors. They single out individual countries and attempt to bully them into rejecting such programs under the banner of the United Nations (falsely) and in the name of international treaties. Their unrelenting and unjustified badgering of signatories to the international treaties that established the INCB is not only unjustified; it is an affront to one of the core purposes of the Board itself: to ensure adequate medical supplies and safe use of controlled substances. The INCB's ill-conceived obsession with intravenousaddiction as a crime flies in the face of the medical view and policies of the World Health Organization and the universally endorsed principles of the General Assembly of the United Nations. The latest target of the INCB is North America's only supervised injection facility, Insite, located in the inner city of Vancouver, Canada. Using the power of their office to meddle in matters of public health for individual nations is without medical, scientific or legal justification. But, most importantly, it is a matter of lifeand death for these most marginalized of citizens. The empirical evidence remains that a significant portion of the continued growth of the AIDS pandemic is due to injecting drug use, and the INCB's intrusion will inevitably result in additional deaths due to preventable HIV infections and drug overdoses. So we are very pleased to call to our readers' attention to a recent report produced by the Canadian HIV/AIDS Legal Network and the International Harm Reduction Development Program (IHRD) joined by former United Nations Special Envoy for HIV/AIDS in Africa, the respected Canadian statesman Stephen Lewis. The full report, "Closed to Reason: The International Narcotics Control Board and HIV/AIDS" is attached along [see Additional file 1] with a Russian translation of the key findings of the authors [see Additional files 2] as well as Russian and Chinese translations of this abstract [see Additional 3 and 4]. As the report makes very clear, the time to inject some accountability and reason into the INCB is now. Howmany times must a man look up Before he can see the sky Yes and how many ears Must one man have Before he can hear people cry? Yes, and how many deaths Will it take till he knows That too many people have died? Bob Dylan
Axial, flexural and torsional rigidities of two-dimensional braided fibre composite medical catheters
Creators: name: Carey, Jason
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Biomedical.
subject: Engineering, Mechanical.

description: The development of a one-piece braided model catheter with the same rigidities as the combined medical catheter-guidewire system presently employed during cardiovascular catheterization procedures is the principal goal of this research. This will result in a significant reduction in the time required to insert a cardiovascular catheter. This is also the first and fundamental step in the development of optimal rigidity cardiovascular catheters. To begin, the axial, torsional and flexural rigidities of existing medical catheters were reviewed and measured. A model to predict the longitudinal tensile and in-plane shear moduli of 2D braided structures, needed for the calculations of the axial, torsional and flexural rigidities of braided tubes, was developed. The sensitivity of the model to key constituent and laminar properties was analysed. It was concluded that accurate values of Efl1, E m and Gm are required for the micromechanical model; the model is not sensitive to the remaining elastic constants (nuf12, nu f23, Gfl2, G23). Oversized braided (Kevlar 49 fibre and thermoset matrix) engineering model composite structures---or model catheters---have been used to verify the model. These model catheters have been produced on an existing braiding machine. Kevlar 49 fibre and epoxy resin have been used primarily because the laminar mechanical properties have been measured in a previous experimental study by Flanagan and Munro [72]. There was good agreement (approximately 6%) between the predicted and measured values of the longitudinal elastic modulus of braided tubes which provided confidence in the model. Shear modulus predictions and the range of experimental results also showed reasonable agreement. The results also show that micromechanical models in which accurate values for important elastic constants (Ef11, Em and G m) are used can accurately predict the experimental results. The preceding experimental work was carried out for full coverage rigid thermoset matrix braided fibre composites. Actual medical catheters require flexible matrix and an open fibre mesh rather than full fibre coverage; therefore, it was necessary to select the appropriate matrix and reinforcement for an actual medical catheter. The proposed CLPT model was used to select the appropriate fibre and resin to obtain rigidities similar to those of the existing medical catheter-guidewire systems. Laminar elastic constants were estimated using micromechanical models. The proposed CLPT model reasonably predicted the longitudinal elastic and shear moduli of model catheters produced with one of the selected elastomeric resins. (Abstract shortened by UMI.)
CAG-encoded polyglutamine length polymorphism in the human genome
Creators: name: Butland, Stefanie L.
name: Devon, Rebecca S.
name: Huang, Yong
name: Mead, Carri-Lyn
name: Meynert, Alison M.
name: Neal, Scott J.
name: Lee, Soo S.
name: Wilkinson, Anna
name: Yang, George S.
name: Yuen, Macaire M.
name: Hayden, Michael R.
name: Holt, Robert A.
name: Leavitt, Blair R.
name: Ouellette, B. F. F.
Publisher: name: BioMed Central
Year: 2016

description: Background: Expansion of polyglutamine-encoding CAG trinucleotide repeats has been identified as the pathogenic mutation in nine different genes associated with neurodegenerative disorders. The majority of individuals clinically diagnosed with spinocerebellar ataxia do not have mutations within known disease genes, and it is likely that additional ataxias or Huntington disease-like disorders will be found to be caused by this common mutational mechanism. We set out to determine the length distributions of CAG-polyglutamine tracts for the entire human genome in a set of healthy individuals in order to characterize the nature of polyglutamine repeat length variation across the human genome, to establish the background against which pathogenic repeat expansions can be detected, and to prioritize candidate genes for repeat expansion disorders. Results: We found that repeats, including those in known disease genes, have unique distributions of glutamine tract lengths, as measured by fragment analysis of PCR-amplified repeat regions. This emphasizes the need to characterize each distribution and avoid making generalizations between loci. The best predictors of known disease genes were occurrence of a long CAG-tract uninterrupted by CAA codons in their reference genome sequence, and high glutamine tract length variance in the normal population. We used these parameters to identify eight priority candidate genes for polyglutamine expansion disorders. Twelve CAG-polyglutamine repeats were invariant and these can likely be excluded as candidates. We outline some confusion in the literature about this type of data, difficulties in comparing such data between publications, and its application to studies of disease prevalence in different populations. Analysis of Gene Ontology-based functions of CAG-polyglutamine-containing genes provided a visual framework for interpretation of these genes' functions. All nine known disease genes were involved in DNA-dependent regulation of transcription or in neurogenesis, as were all of the well-characterized priority candidate genes. Conclusion: This publication makes freely available the normal distributions of CAG-polyglutamine repeats in the human genome. Using these background distributions, against which pathogenic expansions can be identified, we have begun screening for mutations in individuals clinically diagnosed with novel forms of spinocerebellar ataxia or Huntington disease-like disorders who do not have identified mutations within the known disease-associated genes.
Fathering Promotes Child Development in Low- and Middle-Income Countries Through Specific “Active Ingredient” Caregiving Activities
Creators: name: Rothenberg, W. Andrew
name: Bornstein, Marc H.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: Objective. We do not know which specific paternal caregiving practices are associated with more advanced child development in understudied low- and middle-income countries (LMICs). The current investigation attempts to identify such caregiving practices. Design. Maternal reports of six specific paternal caregiving practices which may be uniquely associated with early childhood development were examined in a sample of 159,959 families with 3- to 4-year-old children from 51 LMICs. Both father caregiving practices and early childhood development scores were quantified using measures from UNICEF’s Multiple Indicator Cluster Surveys. Linear regression models examined which paternal caregiving practices were associated with early childhood development after controlling for the contributions of mothers and children’s other caregivers engaging in the same practices as well as father residence in the home and multiple aspects of the physical home environment and national context. Results. When fathers read to their children, named/counted/drew with their children, or sang to their children, their children demonstrated more advanced overall development. When fathers read, named/counted/drew, and told stories to their children, their children also demonstrated more advanced development in literacy/numeracy and approaches to learning. Some effects depended on whether fathers resided in the home. Fathers naming/counting/drawing with their children was associated with more advanced child development in approaches to learning, and fathers reading to their children was associated with more advanced child socioemotional development only if fathers resided in the child’s home. Conclusions. Fathers reading to their children, naming/counting/drawing with their children, and singing to their children appear to be specific “active ingredients” that promote child development in LMICs. Some of these ingredients only actively promote child development when fathers reside in the child’s home environment. These practices should be supported and encouraged in policy and practice. Fathers’ caregiving matters for child development across a wide swath of LMICs in the world.
Excitonic resonances control the temporal dynamics of nonlinear optical wave mixing in monolayer semiconductors
Creators: name: Bauer, Jonas M.
name: Chen, Lijue
name: Wilhelm, Philipp
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Bange, Sebastian
name: Lupton, John M.
name: Lin, Kai-Qiang
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: QUANTUM; PHOTON
subject: 530 Physik

description: Researchers show that resonant coupling of light pulses with excitonic transitions affects the optimal time difference between pulses for sum-frequency generation and four-wave mixing in monolayer WSe2. Monolayer semiconductors are an emerging platform for strong nonlinear light-matter interactions that are enhanced by the giant oscillator strength of tightly bound excitons. Little attention has been paid to the impact of excitonic resonances on the temporal dynamics of such nonlinearities, since harmonic generation and optical wave mixing are generally considered instantaneous processes. We find that a significant time difference, ranging from -40 to +120 fs, is necessary between two light pulses for optimal sum-frequency generation (SFG) and four-wave mixing (FWM) to occur from monolayer WSe2 when one of the pulses is in resonance with an excitonic transition. These resonances involve both band-edge A excitons and high-lying excitons that comprise electrons from conduction bands far above the bandgap. Numerical simulations in the density-matrix formalism rationalize the distinct dynamics of SFG and FWM. The interpulse delays for maximal SFG and FWM are governed primarily by the lifetime of the one-photon and two-photon resonant states, respectively. The method therefore offers an unconventional probe of the dynamics of excitonic states accessible with either one-photon or two-photon transitions. Remarkably, the longest delay times occur at the lowest excitation powers, indicating a strong nonlinearity that offers exploration potential for excitonic quantum nonlinear optics.
Complex distribution of EFL and EF-1α proteins in the green algal lineage
Creators: name: Noble, Geoffrey P.
name: Rogers, Matthew B.
name: Keeling, Patrick J. (Patrick John), 1969-
Publisher: name: BioMed Central
Year: 2015

description: Background: EFL (or elongation factor-like) is a member of the translation superfamily of GTPase proteins. It is restricted to eukaryotes, where it is found in a punctate distribution that is almost mutually exclusive with elongation factor-1 alpha (EF-1α). EF-1α is a core translation factor previously thought to be essential in eukaryotes, so its relationship to EFL has prompted the suggestion that EFL has spread by horizontal or lateral gene transfer (HGT or LGT) and replaced EF-1α multiple times. Among green algae, trebouxiophyceans and chlorophyceans have EFL, but the ulvophycean Acetabularia and the sister group to green algae, land plants, have EF-1α. This distribution singles out green algae as a particularly promising group to understand the origin of EFL and the effects of its presence on EF-1α. Results We have sampled all major lineages of green algae for both EFL and EF-1α. EFL is unexpectedly broad in its distribution, being found in all green algal lineages (chlorophyceans, trebouxiophyceans, ulvophyceans, prasinophyceans, and mesostigmatophyceans), except charophyceans and the genus Acetabularia. The presence of EFL in the genus Mesostigma and EF-1α in Acetabularia are of particular interest, since the opposite is true of all their closest relatives. The phylogeny of EFL is poorly resolved, but the Acetabularia EF-1α is clearly related to homologues from land plants and charophyceans, demonstrating that EF-1α was present in the common ancestor of the green lineage. Conclusion The distribution of EFL and EF-1α in the green lineage is not consistent with the phylogeny of the organisms, indicating a complex history of both genes. Overall, we suggest that after the introduction of EFL (in the ancestor of green algae or earlier), both genes co-existed in green algal genomes for some time before one or the other was lost on multiple occasions.
Gesine Foljanty-Jost; Dieter Rössner (Hrsg.): Gewalt unter Jugendlichen in Deutschland und Japan. Ursachen und Bekämpfung
Creators: name: Banze, Sonja
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 67 (1998): ASIEN (April)
Data sharing in paediatric clinical research – A protocol (conect4children)
Creators: name: Mariagrazia Felisi
name: Bonifazi, Fedele
name: Toma, Maddalena
name: Pansieri, Claudia
name: Leary, Rebecca
name: Hedley, Victoria
name: Cornet, Ronald
name: Reggiardo, Giorgio
name: Landi, Annalisa
name: Canham, Steve
name: Nally, Sinéad
name: Ceci, Adriana
Publisher: name: Zenodo
Year: 2022
Subjects: Data sharing; Clinical Trials; Peadiatrics

description: Conducting clinical trials (CTs) in the paediatric population can be difficult due to ethical, regulatory, methodological, and commercial issues influencing many factors such as procedures, sample size, and company strategies. On one hand, the lack of evidence-based research and the unmet medical needs, and on the other hand, the low investment of pharma companies in paediatric research, are increasingly promoting the use of existing resources. Sharing CTs data offer many potential benefits without conducting new studies. Although strongly recommended, a few initiatives sharing CTs data in the paediatric field still exist. In the framework of Work Package 5 “Data coordinating center and data quality standards”, scouting of initiatives (such as platforms, projects, private and public initiatives of pharma industries or no-profit organization, consortium of Sponsors/Funders, databases of pharma industries, or no-profit organization, etc.) sharing CTs data, with a focus on paediatric data, will be performed following a specific protocol.
Extract from a MS. diary of Peter le Neve, Esq, Norroy king of arms, entitled Memoranda in Heraldry of such entries as relate to the county of Norfolk. (Part 1 - Part 2 on P111 - Part 3 on P369)
Creators: name: Carthew, G A
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 2 (1), 23-34
A new role for human immunodeficiency virus (HIV)-1 protease inhibitors: Suppression of apoptosis
Creators: name: Phenix, Barbara N
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.
subject: Health Sciences, Immunology.

description: Protease inhibitor (PI)-induced improvements in CD4 T cell counts may be in part independent of PI effects on HIV replication. Since HIV-associated CD4 T cell depletion occurs by apoptosis, we analysed the effect of Pis on apoptosis in peripheral blood lymphocytes (PBLs) from HIV-infected patients and in an uninfected T cell line. The in vivo effects of Pis were monitored in an animal model of stroke and in HIV negative patients taking anti-retroviral therapy (ART) in the context of post-exposure prophylaxis (PEP). Patient PBLs and Jurkat T cells were cultured with Pis. Following stimulation, apoptosis was measured by annexin-V, and loss of mitochondrial membrane permeability (Deltapsim) was assessed in cells and isolated mitochondria using DiOC6(3). The mechanism of inhibition was determined at the level of caspase activity, and of protein and messenger ribonucleic acid (mRNA) synthesis of various pro- or antiapoptotic factors. For in vivo experiments, mice were given Pis by gastric lavage at various time points prior to and following transient forebrain ischaemia. Histological analyses were performed on hippocampal sections. Apoptosis of ex vivo peripheral blood mononuclear cells (PBMCs) of patients taking PEP (AZT, lamivudine, nelfinavir) was assessed prior to, on, and post-therapy in response to a variety of stimuli. Results revealed that Pis reduced spontaneous and anti-Fas induced apoptosis both in CD4 and CD8 T cells from HIV patients. Jurkat T cell apoptosis, Deltapsi m, cytochrome c release, and caspase 8 cleavage were also inhibited by Pis. The mechanism responsible for inhibition of apoptosis does not involve modification of caspase activity, protein, or mRNA synthesis. Mitochondrial involvement was confirmed following inhibition of viral protein R (Vpr)- and atractyloside (Atr)-induced Deltapsim of isolated mitochondria. Apoptosis in hippocampal sections of mice having undergone transient forebrain ischaemia was inhibited by PI treatment, as was camptothecin-induced apoptosis in PBMCs from patients taking PEP. In conclusion, Pis inhibit apoptosis in PBLs from HIV-infected patients and in uninfected Jurkat T cells. The mechanism appears to involve mitochondria, as inhibition of Vpr- and Atr-induced Deltapsim of isolated mitochondria was observed. Stroke-induced apoptosis may be inhibited in vivo by Pis, and importantly, survival following anti-Fas challenge may be positively influenced.
Friedrich Fürstenberg, Renate Ruttkowski: Bildung und Beschäftigung in Japan. Steuerungs- und Abstimmungsaspekte
Creators: name: Banze, Sonja
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 67 (1998): ASIEN (April)
Uptake of NO3 on soot and pyrene surfaces.
Creators: name: Mak, Jackson
name: Gross, Simone
name: Bertram, Allan K.
Publisher: name: American Geophysical Union
Year: 2016

description: The reaction of NO3 with methane soot, hexane soot, and solid pyrene was investigated using a flow tube reactor. The uptake of NO3 on fresh soot was fast (uptake coefficient >0.1). Based on this result and an assumed density of reactive sites on soot, the time to process or oxidize 90% of a soot surface in the atmosphere would take only approximately five minutes. This suggests that NO3 chemistry can rapidly oxidize soot surfaces under atmospheric conditions. After exposing soot films to NO3 for approximately 180 minutes in the laboratory, the uptake reaches a steady‐state value. The steady state uptake coefficients (assuming a geometric surface area) were 0.0054 ± 0.0027 and 0.0025 ± 0.0018 for methane and hexane soot, respectively. These numbers are used to show that heterogeneous reactions between NO3 and soot are not likely a significant sink of gas‐phase NO3 under most atmospheric conditions. The uptake of NO3 on fresh pyrene surfaces was also fast (uptake coefficient >0.1), and much faster than previously suggested. We argue that under certain atmospheric conditions reactions between NO3 and surface‐bound polycyclic aromatic hydrocarbons (PAHs) may be an important loss process of PAHs in the atmosphere. An edited version of this paper was published by AGU. Copyright 2007 American Geophysical Union.
LandslideRecoveryModeling
Creators: name: Fang, Zhice
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 401302
subject: Geospatial information systems and geospatial data modelling

description: Data and codes for the manuscript "Data-driven modeling reveals net primary productivity recovery of post-seismic landslides after the 2008 Wenchuan earthquake"
Nuclear import of influenza A viral ribonucleoprotein complexes is mediated by two nuclear localization sequences on viral nucleoprotein
Creators: name: Wu, Winco W
name: Sun, Ying-Hua B
name: Panté, Nelly
Publisher: name: BioMed Central
Year: 2016

description: Background: The influenza A virus replicates in the nucleus of its host cell. Thus, entry of the influenza genome into the cell nucleus is necessary for establishing infection. The genome of the influenza A virus consists of eight single-stranded, negative-sense RNA molecules, individually packed with several copies of the viral nucleoprotein (NP) into ribonucleoprotein particles (vRNPs). These vRNPs are large, rod-shaped complexes containing a core of NP, around which the RNA is helically wrapped. The vRNPs are the entities that enter the nucleus, and their nuclear import must be mediated by nuclear localization sequences (NLSs) exposed on the vRNPs. NP contains at least two putative NLSs, one at the N-terminus (NLS1) and one in the middle (NLS2) of the protein. These NP NLSs have been shown to mediate the nuclear import of recombinant NP molecules. However, it remains to be determined which NLS mediates the nuclear import of influenza vRNP complexes. Results: To directly track the nuclear import of the influenza A genome, we developed an experimental assay based on digitonin-permeabilized cells and fluorescently-labeled vRNPs isolated from the influenza A virus. We used this assay to determine the contribution of the two proposed NLSs on NP to the nuclear import of influenza vRNP complexes. Peptides that mimic each of the two NLSs on NP were used to compete with vRNPs for their nuclear import receptors. In addition, antibodies against the two NP NLSs were used to block the NLSs on the vRNP complexes, and thereby inhibit vRNP nuclear import. Both peptide competition and antibody inhibition of either sequence resulted in decreased nuclear accumulation of vRNPs. The two sequences act independently of each other, as inhibition of only one of the two NLSs still resulted in significant, though diminished, nuclear import of vRNPs. Furthermore, when both sequences were blocked, vRNP nuclear import was almost completely inhibited. Antibody inhibition studies further showed that NLS1 on NP is the main contributor to the nuclear import of vRNPs. Conclusion: Our results demonstrate that both NLS1 and NLS2 on NP can mediate the nuclear uptake of influenza A vRNPs.
Sylvia Bräsel, Mi-He Kim, He-Yong Chong (Hrsg.): "Eines Tages ohne Tränen .." Zeitgenössische Literatur aus Korea.
Creators: name: Rentner, Reta
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 67 (1998): ASIEN (April)
Androgen-regulated genes differentially modulated by the androgen receptor coactivator L-dopa decarboxylase in human prostate cancer cells
Creators: name: Margiotti, Katia
name: Wafa, Latif A.
name: Cheng, Helen
name: Novelli, Giuseppe
name: Nelson, Colleen C.
name: Rennie, Paul S.
Publisher: name: BioMed Central
Year: 2016

description: Background: The androgen receptor is a ligand-induced transcriptional factor, which plays an important role in normal development of the prostate as well as in the progression of prostate cancer to a hormone refractory state. We previously reported the identification of a novel AR coactivator protein, L-dopa decarboxylase (DDC), which can act at the cytoplasmic level to enhance AR activity. We have also shown that DDC is a neuroendocrine (NE) marker of prostate cancer and that its expression is increased after hormone-ablation therapy and progression to androgen independence. In the present study, we generated tetracycline-inducible LNCaP-DDC prostate cancer stable cells to identify DDC downstream target genes by oligonucleotide microarray analysis. Results: Comparison of induced DDC overexpressing cells versus non-induced control cell lines revealed a number of changes in the expression of androgen-regulated transcripts encoding proteins with a variety of molecular functions, including signal transduction, binding and catalytic activities. There were a total of 35 differentially expressed genes, 25 up-regulated and 10 down-regulated, in the DDC overexpressing cell line. In particular, we found a well-known androgen induced gene, TMEPAI, which wasup-regulated in DDC overexpressing cells, supporting its known co-activation function. In addition, DDC also further augmented the transcriptional repression function of AR for a subset of androgen-repressed genes. Changes in cellular gene transcription detected by microarray analysis were confirmed for selected genes by quantitative real-time RT-PCR. Conclusion: Taken together, our results provide evidence for linking DDC action with AR signaling, which may be important for orchestrating molecular changes responsible for prostate cancer progression.
Relay Attack in RFiD Systems Analysis and Modeling
Creators: name: Lima, Jose Augusto
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Engineering, Electronics and Electrical.

description: A relay attack on an RFiD system is carried out by a team of two attackers: one stationed near the victim, and using a rogue Reader to activate the victim's TAG; and another stationed near the legitimate Reader, using a high-speed communication system to relay the communication between the victim's TAG to the legitimate Reader through the attackers in real time. The relay attack is one of the most significant threats to the security of RFiD systems, because it is difficult to detect, is not thwarted by standard challenge-and-response security protocols and is independent of any cryptographic algorithms used to secure the RFiD communication. In this thesis, we present an analysis of the relay attack in an RFiD communication system, including an analysis of the many factors which limit the distance at which the attack may be carried out. A detailed Simulink model of an RFiD communication system was constructed in the IEEE14443 standard, and used to provide a simulation of the attack. The simulations show the feasibility of the relay attack. Finally, three relay attack countermeasures are proposed, together with an estimation of the probability of success for each.
Development guidelines for marketing mix Cultural tourism In Ratchaburi ProvinceIn Ratchaburi Province.
Creators: name: Kanokwan Silaswan
Publisher: name: Faculty of Management Science Nakhon Pathom Rajabhat University
Year: 2019
Subjects: Marketing mix
Cultural tourism, Ratchaburi Province

description: Journal of Management Science Nakhon Pathom Rajabhat University, 6, 2, 131-146
«ОСНОВНЫЕ ПРИНЦИПЫ И ПРАВИЛА РУССКОЙ ДЕЛОВОЙ КОММУНИКАЦИИ»
Creators: name: Уразова, Айзада
Publisher: name: Zenodo
Year: 2024

description: Деловое общение играет важную роль в рабочей среде. Несмотря на кажущуюся простоту, деловые коммуникации отличаются от бытовых и требуют особого подхода. Основы делового общения не только облегчает рабочие процессы, но и формирует позитивное впечатление о вас, как о профессионале. Деловой разговор — это понимаемый в широком смысле устный речевой контакт между людьми, объединяемыми профессиональными деловыми интересами. Деловой разговор ведется между людьми, которые обличены полномочиями для решения деловых вопросов.
Molecular engineering and nanostructuring of polymer networks for high performance gas separation membranes
Creators: name: Kurdi, Jamal
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Chemical.

description: The architecturing and characterization of polymer-based materials at a molecular scale are of great importance in the development of novel rigid polymeric molecular sieves for high performance gas separation membranes. The new rapidly growing field of nanoscience technologies and material nanostructuring offers novel ways for creating nanoengineered material combinations. Intermolecular and supramolecular interactions among different molecules and clusters play an important role in the microscopic behavior of molecular architectures and molecular self-assembly. In this work, the coordination shell number of polyetherimide (PEI) membranes was determined from experimental X-ray diffraction data and found to be a key link between microscopic pair intermolecular interactions and macroscopic scale interactions. This link enabled us to determine the intermolecular force parameters required to understand material structuring at a molecular scale. These physical parameters are required in all models used in the determination of the micropore size distributions from gas adsorption isotherms. Computational chemistry and physicochemical principles were useful to illustrate molecular architecturing and coordinating to form intermediate stable molecular complexes during membrane fabrication. These coordination complexes acted as pore forming templates that could be disrupted and removed after polymer coagulation to open the closed PEI network structure and increase the interconnectivity and accessibility among polymer micropores. Based on nanotechnology concepts, a uniform dispersion of nanoscopically-sized filler particles into a polymer network created novel materials with superior properties and characteristics attributed to the presence of ultra-large interfacial area per unit volume. The adhesive (noncovalent interactions among different molecules) properties of nanoelement surfaces and polymer surfaces were the key for the creation of uniform polymeric molecular sieves. Narrowing the micropore size distribution is also possible when the adhesive energy between nanoparticles and polymer phase exceeds the cohesive energy of the pure polymer. Membranes were prepared using twelve metal-ligand complexes as filler additives that were uniformly dispersed into the PEI polymer solution before membrane casting. Membranes containing cobalt phthalocyanine (CoPc) showed the highest performance for oxygen separation from air. However, the performance was largely decreased upon annealing indicating a low nanostructure stability. (Abstract shortened by UMI.)
Network Management For Academic Works Support To The Community Of Rajabhat Universities In The Western RegionOf Rajabhat Universities In The Western Region
Creators: name: Phattharaporn Jaipheng
Publisher: name: Faculty of Management Science Nakhon Pathom Rajabhat University
Year: 2019
Subjects: network
academic works to the community
Rajabhat university in the western region

description: Journal of Management Science Nakhon Pathom Rajabhat University, 6, 2, 147-161