cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chemical composition and larvicidal activity of Zanthoxylum armatum against diamondback moth, Plutella xylostella
Creators: name: Vishal Kumar
name: Kumar, Neeraj
name: Singh, Bikram
name: S.G. Eswara Reddy
name: Chauhan, Urvashi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Physics
subject: Biochemistry

description: The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Yponomeutidae) is the most serious pest of cruciferous crops grown in the world causing economic yield loss. Several synthetic insecticides have been used against P. xylostella but satisfactory control was not achieved due to development of resistance to insecticides. Therefore, the present study was carried out to screen different fractions of Zanthoxylum armatum for their insecticidal activities against second instar larvae of P. xylostella. Results indicate, all the fractions showed activity to P. xylostella. However, n-hexane fraction of Z. armatum showed maximum larvicidal activity with minimum LC50 value of 2988.6 ppm followed by ethanol (LC50 = 12779.7 ppm) and methanol fraction (LC50 = 12908.8 ppm) whereas chloroform fraction was least toxic (LC50 = 16750.6 ppm). The GC–MS analysis of n-hexane fraction of leaf extract showed maximum larvicidal activity, which may be due to two major compounds i.e. 2-undecanone (19.75%) and 2-tridecanone (11.76%).
Economy, Type of Government, and Strategic Timing of Elections: Calling Opportunistic Early Elections in OECD Democracies
Creators: name: Riera, Pedro
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Biotechnology

description: Although mainstream models of accountability assume that the election date is exogenously fixed, in almost any parliamentary democracy governments may choose it. This article proposes a theory of the strategic timing of elections that highlights the role of the economy and the type of government. First, incumbents will call early elections when the economy is growing and inflation rates are low. Nevertheless, coalition and majority governments will fall short of the ability and the incentives to do so, respectively. As a result, the effect of the state of the economy on the opportunistic dissolution of the parliament will be stronger when there is only one party in government, and it lacks a majority in the lower house. These patterns are examined by using data from 21 Organisation for Economic Cooperation and Development democracies between 1945 and 2010.
Corrigendum: Effective renormalized multi-body interactions of harmonically confined ultracold neutral bosons (New Journal of Physics (2012) 14 (053037) DOI: 10.1088/1367-2630/14/5/053037)
Creators: name: Johnson, P. R.
name: Blume, D.
name: Yin, Xiangyu
name: Flynn, W. F.
name: Tiesinga, E.
Publisher: name: Swinburne
Year: 2024

description: Abstract not available.
Whole-rock geochemical reference data for Torlesse and Waipapa terranes, North Island, New Zealand
Creators: name: RC Price
name: N Mortimer
name: IEM Smith
name: R Maas
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Physiology

description: Sixteen metasedimentary rocks from the Waipapa and Torlesse composite terranes of New Zealand’s North Island have been analysed for major and trace elements and Sr, Nd and Pb isotope composition. The new data provide a comprehensive analytical dataset that can be used for quantitative trace element and isotopic modelling of the petrogenesis of Neogene North Island volcanic rocks. The major and trace element and isotope data confirm previously recognised systematic compositional differences between Waipapa and older Torlesse (Kaweka Terrane) metasedimentary rocks. Kaweka Terrane samples tend to have higher SiO2, Al2O3, Cs, Rb, Th, U, Hf and total rare earth elements (REE) abundances and chondrite normalised REE patterns characterised by light/heavy REE enrichment. Fe2O3, MgO, Sr and Sc contents are lower in Kaweka samples than those observed in their Waipapa Terrane counterparts. 87Sr/86Sr ratios are lower and 143Nd/144Nd values are higher in Waipapa compared to Kaweka samples, and Pb is isotopically more radiogenic in the Kaweka samples. Younger Torlesse (Pahau Terrane) samples have major and trace element and isotopic compositions that span the Waipapa and Kaweka suites, but overall they are more similar to the former. Mudstones from all terranes converge in bulk composition and there are systematic differences in isotopic composition between mudstones and sandstones from the Kaweka and particularly the Waipapa terranes. Both lithologies need to be considered when estimating the compositions of metasedimentary terranes. Major and trace element and isotope compositions of the metasediments indicate a complex provenance involving subduction-related volcanic and crustal or continental inputs.
Public Discourses of Climate Change in Hong Kong
Creators: name: Lo, Alex Y.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: The changing political environment in Hong Kong is likely to accelerate the transition in environmental policy discourse. Opportunities for critical public involvement are increasing and new environmental discourses are emerging. Yet, previous social surveys did not explore the range of these discourses and few focused on climate change. The paper outlines the public discourses of climate change in Hong Kong. Using Q-methodology, four distinctive discourses were identified, namely Pure Environmentalism, Political Pragmatism, Popular Optimism, and Fair Rationalism. While the first one is climate-centric, the other three are political or social in nature and do not indicate a clear or coherent climate orientation. This suggests that the climate change concern of the Hong Kong public is not tightly embedded into a coherent narrative of social and institutional transformation. Effective climate change governance and policies require strengthening the link between such concern and the public desires for social and institutional transformation. Bringing together the ongoing social movements and environmental campaigns will be instrumental to nurture an active climate citizenry.
Harmonically trapped two-atom systems: Interplay of short-range s -wave interaction and spin-orbit coupling
Creators: name: Yin, Xiangyu
name: Gopalakrishnan, S.
name: Blume, D.
Publisher: name: Swinburne
Year: 2024

description: The coupling between the spin degrees of freedom and the orbital angular momentum has a profound effect on the properties of nuclei, atoms, and condensed-matter systems. Recently, synthetic gauge fields have been realized experimentally in neutral cold-atom systems, giving rise to a spin-orbit coupling term with "strength" kso. This paper investigates the interplay between the single-particle spin-orbit coupling term of Rashba type and the short-range two-body s-wave interaction for cold atoms under external confinement. Specifically, we consider two different harmonically trapped two-atom systems. The first system consists of an atom with spin-orbit coupling that interacts with a structureless particle through a short-range two-body potential. The second system consists of two atoms that both feel the spin-orbit coupling term and that interact through a short-range two-body potential. Treating the spin-orbit term perturbatively, we determine the correction to the ground-state energy for various generic parameter combinations. Selected excited states are also treated. An important aspect of our study is that the perturbative treatment is not limited to small s-wave scattering lengths but provides insights into the system behavior over a wide range of scattering lengths, including the strongly interacting unitary regime. We find that the interplay between the spin-orbit coupling term and the s-wave interaction generically enters, depending on the exact parameter combinations of the s-wave scattering lengths, at order kso2 or kso4 for the ground state and leads to a shift of the energy of either sign. While the absence of a term proportional to kso follows straightforwardly from the functional form of the spin-orbit coupling term, the absence of a term proportional to kso2 for certain parameter combinations is unexpected. The well-known fact that the spin-orbit coupling term couples the relative and center-of-mass degrees of freedom has interesting consequences for the trapped two-particle systems. For example, we find that, for certain parameter combinations, the spin-orbit coupling term turns sharp crossings into avoided crossings with an energy splitting proportional to kso. Our perturbative results are confirmed by numerical calculations that expand the eigenfunctions of the two-particle Hamiltonian in terms of basis functions that contain explicitly correlated Gaussians.
Alteration of iron stores in women of reproductive age with HIV in Abidjan (Côte D’ivoire)
Creators: name: Iqbal, Zahid
name: Soualio Kamagate1
name: Mathieu N. Bleyere1*,
name: Leandre K. Kouakou1
name: Kone Mama1
name: Doumate2, Sylvie
name: Amonkan3, Augustin K.
name: Konan3, André B.
name: Duni Sawadogo4
name: Ehile1, Etienne E.
name: Yapo1, Paul A.
Publisher: name: figshare
Year: 2015
Subjects: subject: Molecular Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biological Engineering
subject: Biological Techniques
subject: Biotechnology
subject: Genetics

description: The aim of this study is to evaluate and to characterize the iron metabolism in women of reproductive age infected by VIH in Abidjan. In order to review the iron stores in women of reproductive age, 180 women were recruited in a specialized center for treatment of HIV (ICBRA) based on the criteria for inclusion and exclusion. The mean age of women was 34.7 ± 0.5 years with extremes of 18 and 45 years. These women were classified into two groups of subjects namely 120 HIV positive women and 60 HIV negative as control women. Blood samples were taken from each of the selected women. Assays of various biological indicators (haematological and biochemical parameters) assessment of iron status were performed by different kits adequate for the automatic COBAS INTEGRA 400 Plus. The results of our investigations have demonstrated that all the searched biological has been degraded in enrolled women. Indeed our study found that for all subjects 79.4 % of women reported an abnormal iron status namely 71.7 % and 83.3 % respectively in control women and women with HIV. Abnormal iron status consisted of iron deficiency, iron deficiency anaemia, inflammatory anaemia and inflammatory anaemia associated with iron deficiency. Among the observed various components of iron status, inflammatory anaemia revealed the high prevalence rates in both groups of subjects (46.7 % vs 67.5 %). Our findings have then indicated that HIV infection has dramatically altered iron stores in women of reproductive especially those living with HIV/AIDS.
Effective renormalized multi-body interactions of harmonically confined ultracold neutral bosons
Creators: name: Johnson, P. R.
name: Blume, D.
name: Yin, Xiangyu
name: Flynn, W. F.
name: Tiesinga, E.
Publisher: name: Swinburne
Year: 2024

description: We calculate the renormalized effective two-, three- and fourbody interactions for N neutral ultracold bosons in the ground state of an isotropic harmonic trap, assuming two-body interactions modeled with the combination of a zero-range and energy-dependent pseudopotential. We work to third-order in the scattering length at(0) defined at zero collision energy, which is necessary to obtain both the leading-order effective fourbody interaction and consistently include corrections for realistic two-body interactions. The leading-order, effective three- and four-body interaction energies are U3 (ω)= -(0.85576...)[at(0)/σ (ω)]2 + 2.7921(1)[at(0)/σ (ω)]3 + O(a4
 t) and U4(ω)= +(2.43317...)[at(0)/σ (ω)]3 +O(a4
 t), where ω and σ(ω) are the harmonic oscillator frequency and length, respectively, and energies are in units of hω. The one-standard deviation error ±0.0001 for the third-order coefficient in U3(ω) is due to numerical uncertainty in estimating a slowly converging sum; the other two coefficients are either analytically or numerically exact. The effective three- and four-body interactions can play an important role in the dynamics of tightly confined and strongly correlated systems. We also performed numerical simulations for a finite-range (FR) boson-boson potential, and it was comparison to the zero-range predictions which revealed that finiterange effects must be taken into account for a realistic third-order treatment. In particular, we show that the energy-dependent pseudopotential accurately captures, through third order, the finite-range physics, and in combination with the multi-body effective interactions gives excellent agreement with the numerical simulations, validating our theoretical analysis and predictions.
Acute toxicity study and effects of sesame (Sesamum radiatum) aqueous leaf extract on rabbit’s electrocardiogram
Creators: name: Iqbal, Zahid
name: B André Konan1
name: KG Marcel Bouafou2
name: N Mathieu Bléyéré3
name: Zannou-Tchoko1, Viviane
name: Amonkan1, Augustin
name: K Raphaël Oussou3
name: Y Jacques Datté1
Publisher: name: figshare
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 60506 Virology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Toxicology
subject: Biological Techniques
subject: Molecular Biology
subject: Genetics

description: Our studies examined the acute toxicity, the natural bioactive compounds contained in the aqueous leaf extract (ESera) and its actions on the electrocardiogram. They were therefore aimed to confirm the use in traditional medicine for the treatment of cardiovascular diseases and childbirth complications. After the revelation of the phytochemical compounds in S. radiatum leaves by general reactions, the determination of LD50 of acute toxicity in mice was achieved after treatment with the aqueous leaf extract (ESera). ESera was administrated intraveinously to the animal via the saphenous vein for ECG registration. The phytochemical analysis revealed the presence of quinones, tannins, alkaloids, sterols, terpens, polyphenols, saponosides and reducing compounds. Short treatments (24 hours) of mice with the leaves aqueous extract gave LD50 values of 169.7 ± 15 mg/kg of b.w. and of 184.2 ± 21 mg/kg of b.w., respectively by the method of Miller and Tainter and the method of Dragstedt and Lang. ESera induced negative inotrope and chronotrope actions on the global electric activity of rabbit. In Conclusion: 1. The aqueous leaf extract has a low toxicity which permits its uses by populations. 2. As shown by the electrocardiac investigation and the phytochemical study of the leaves, S. radiatum could have many pharmacological properties justifying its traditional use to treat many diseases including cardiovascular diseases and childbirth complications.
A cloud-based teaching framework: an introduction
Creators: name: Robab Saadatdoost
Publisher: name: figshare
Year: 2015
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: Education

description: Abstract: One of the most significant discussions in education and information technology is cloud computing. Over the past six years, researchers have shown an increased interest in cloud computing for educational contexts.
However, these rapid changes in information technology have a serious effect on teaching frameworks. Concerns have been raised about how cloud computing can be integrated with teaching frameworks and if it can improve teaching. In this paper, the Danielson Teaching Framework, which focuses on key aspects of teaching, was used. This framework has divided complex teaching activities into components such as communicating with students, students engagement and others which all might be improved by cloud computing; using cloud computing has capability to enhance performance of
teaching. This paper seeks to address the domains of teaching frameworks and introduce an initial version of a cloud-based teaching framework that
considers cloud computing can provides insight to future research on teaching frameworks.
Keywords:
cloud computing; online education; e-learning; teaching framework; cloud-based teaching framework; Danielson teaching framework; management in education.
A NETNOGRAPHY STUDY OF MOOC COMMUNITY
Creators: name: Robab Saadatdoost
Publisher: name: figshare
Year: 2015
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: Education

description: Massive online open courses (MOOC) are one of the widely used groups of online education and have
been thought of as a key factor in future education. In recent years, there has been an increasing
interest in MOOC from education and information systems researchers. In this paper, the aim is to
observe MOOC in their natural setting to examine a particular community of MOOC by drawing on
the concepts of communities of practice as a theoretical lens. One of the most significant current
discussions on MOOC is Coursera. Questions have been raised about the structure of an emergent
type of community within MOOC. However, far too little attention has been paid to study community
of practice in this type of online education. The authors conducted an online ethnographic study on a
sample of discussion forums of Coursera. Discussions were qualitatively content analyzed in order to
understand the structure of an emergent type of community within MOOC. Our ﬁndings suggest that
cohesion in a MOOC community is brought about by the domain of doubts, questions, new knowledge,
experiences and the community of learners who meet people around the world with similar interests;
the practices of documents, information, ideas, stories, experiences and software sharing. The
combination of forces for MOOC community are global, free and online education identity of
community which provides great materials, top professors, mass participation and certificates from
top universities; voting system for warrant; movement of new comers from peripheral to the core of
community by contributing more in discussions.
Product allocation problem for an AS/RS with multiple in-the-aisle pick positions
Creators: name: Faraz Ramtin
name: Pazour, Jennifer A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Biophysics

description: An automated storage/retrieval system with multiple in-the-aisle pick positions is a semi-automated case-level order fulfillment technology that is widely used in distribution centers. We study the impact of product to pick position assignments on the expected throughput for different operating policies, demand profiles, and shape factors. We develop efficient algorithms of complexity O(nlog(n)) that provide the assignment that minimizes the expected travel time. Also, for different operating policies, shape configurations, and demand curves, we explore the structure of the optimal assignment of products to pick positions and quantify the difference between using a simple, practical assignment policy versus the optimal assignment. Finally, we derive closed-form analytical travel time models by approximating the optimal assignment's expected travel time using continuous demand curves and assuming an infinite number of pick positions in the aisle. We illustrate that these continuous models work well in estimating the travel time of a discrete rack and use them to find optimal design configurations.
Abundance, Survival, and Life History Strategies of Juvenile Chinook Salmon in the Skagit River, Washington
Creators: name: Zimmerman, Mara S.
name: Kinsel, Clayton
name: Beamer, Eric
name: Connor, Edward J.
name: Pflug, David E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Marine Biology
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Biophysics

description: To identify potential actions for conserving Chinook Salmon Oncorhynchus tshawytscha in the Skagit River, Washington, we used a 16-year time series of streamflow data, adult escapement, and out-migrant abundance to understand how out-migrant abundance and life history diversity were related to spawner abundance and incubation flows. Three freshwater rearing strategies were distinguished based on body size at out-migration: fry (≤45 mm FL), subyearling parr (46–100 mm FL), and yearling smolts (>100 mm FL). Density-independent and density-dependent processes were hypothesized to influence survival in sequence, with density-independent mechanisms operating during incubation and density-dependent mechanisms operating between emergence and out-migration. A model selection process compared spawner–recruit models with and without different incubation flow metrics. Density-independent models that included measures of flow duration and magnitude were strongly supported (Akaike's information criterion [AIC] difference ≤ 3). Sustained flow events of moderate magnitude (1-year recurrence interval) were an equivalent if not better predictor of freshwater survival than short-duration flow events of high magnitude (peak flows). A second model selection process evaluated density dependence of each life history type. The composition of out-migrants (fry, subyearling parr, and yearling smolts) was a density-dependent function of spawner abundance. Fry out-migrant abundance was density independent, and subyearling parr out-migrant abundance was density dependent. Neither model was supported for yearling smolts. At least one out-migrant life history, subyearling parr, should benefit from continued restoration of freshwater habitats in the Skagit River system. Factors contributing to the yearling smolt life history will benefit from additional study.Received October 12, 2014; accepted February 3, 2015
Product Allocation Problem for an AS/RS with Multiple in-the-Aisle Pick Positions
Creators: name: Faraz Ramtin
name: Pazour, Jennifer A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Biophysics

description: An automated storage/retrieval system (AS/RS) with multiple in-the-aisle pick positions (MIAPP-AS/RS) is a semi-automated case-level order fulfillment technology that is widely used in distribution centers. We study the impact of product to pick position assignments on the expected throughput for different operating policies, demand profiles, and shape factors. We develop efficient algorithms of complexity O(nlog(n)) that provide the assignment that minimizes the expected travel time. Also, for different operating policies, shape configurations, and demand curves, we explore the structure of the optimal assignment of products to pick positions and quantify the difference between using a simple, practical assignment policy versus the optimal assignment. Finally, we derive closed-form analytical travel time models by approximating the optimal assignment's expected travel time using continuous demand curves and assuming an infinite number of pick positions in the aisle. We illustrate that these continuous models work well in estimating the travel time of a discrete rack and use them to find optimal design configurations.
Time wave Interference Theory: Virtual Reality Test V001
Creators: name: Kitchen, Kris
Publisher: name: figshare
Year: 2015
Subjects: subject: 20104 Galactic Astronomy
subject: FOS: Physical sciences
subject: Cosmology
subject: Astrophysics
subject: Special Relativity
subject: Applied Physics
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Computational Physics
subject: Atomic Physics
subject: Applied Computer Science
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Computation Theory and Mathematics
subject: Distributed Computing
subject: Data Format
subject: M-Theory
subject: General Relativity
subject: Applied Psychology
subject: Clinical Psychology
subject: Developmental and Educational Psychology
subject: Neuroscience and Physiological Psychology
subject: Organizational Behavioral Psychology
subject: 20203 Particle Physics
subject: Plasma Physics
subject: Condensed Matter Physics
subject: Mechanics
subject: Thermodynamics
subject: Entropy
subject: Quantum Mechanics
subject: 91308 Solid Mechanics
subject: FOS: Mechanical engineering
subject: Personality, Social and Criminal Psychology
subject: Artificial Intelligence and Image Processing
subject: Extragalactic Astronomy

description: Time wave Interference: Virtual Reality Test V001
Identification and optimization of TDP1 inhibitors from anthraquinone and chalcone derivatives: consensus scoring virtual screening and molecular simulations
Creators: name: Moshawih, Said
name: Goh, Hui Poh
name: Kifli, Nurolaini
name: Darwesh, Mohammed Abd ElFattah
name: Ardianto, Chrismawan
name: Goh, Khang Wen
name: Ming, Long Chiau
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Virtual screening aims to identify and rank compounds with drug/lead-like properties based on their affinity for the protein target. We developed a methodology that integrates structure- and ligand-based screening approaches to enhance hit rates against the TDP1 protein within a database of anthraquinone and chalcone derivatives, followed by evaluation of prioritized compounds through molecular simulations. This technique is particularly useful for training set imbalances. Four screening methods were used: QSAR, pharmacophore, shape similarity, and docking. Each method was individually trained to score compounds, and the scores were fused to create parallel Z-score fusion. The QSAR models exhibited satisfactory R2 values (0.84 to 0.75), whereas the pharmacophoric and shape similarity models demonstrated excellent performance (ROC:0.82–0.88). Docking enrichment analysis identified 6N0D as the optimal TDP1 crystal structure (ROC = 0.73). Remarkably, the consensus scoring method surpassed other screening methods, achieving the highest ROC value of 0.98. Docking screening prioritized compounds with binding modes resembling the co-crystallized ligands, whereas MMGBSA, consensus, and docking produced dynamic simulations that were as stable as the co-crystallized ligands. Additionally, the QSAR-selected compounds exhibited binding modes similar to those of commercially available TDP1 inhibitors. In this study, a strong correlation was found between the inhibitory concentrations and binding energy values of commercialized TDP1 inhibitors, indicating that the top-ranked compounds are expected to have potent inhibitory effects in the nano-/micromolar range. The results of this study establish that consensus scoring can be used as an adaptable mainstay virtual screening methodology, pending subsequent experimental validation for affirmation. Communicated by Ramaswamy H. Sarma
Towards targeting EGFR and COX-2 inhibitors: comprehensive computational studies on the role of chlorine group in novel thienyl-pyrazoline derivative
Creators: name: Wulan, Fia Fathiana
name: Wahyuningsih, Tutik Dwi
name: Astuti, Endang
name: Prasetyo, Niko
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: To enhance the effectiveness of chemotherapy and overcome resistance, scientists must develop novel drugs or scaffolds that have a combined effect, such as the inhibition of EGFR and COX-2. This research employed virtual screening techniques, such as docking, and dynamics simulation, to predict chlorinated thienyl-pyrazoline derivatives that inhibit these proteins. The study proposed eleven (11) ligands with binding energies ranging from −7.8 kcal/mol to −8.7 kcal/mol for EGFR and −6.4 kcal/mol to −8.4 kcal/mol for COX-2. Ligands P1 and P11 exhibited the highest binding affinity for both proteins. The results of RMSD, RMSF, RoG, SASA the number of hydrogen bonds, and BAR free binding energy demonstrated the good stability of ligands P1 and P11 when binding to both proteins over 180 ns simulations. In addition, the absorption, distribution, metabolism, excretion, and toxicity properties of the selected ligands were assessed to predict their toxicity and drug likeliness. Based on the results, these compounds can be proposed for further synthesis and in vitro studies. Communicated by Ramaswamy H. Sarma
Influence of environmental factors on removal of oxides of nitrogen by a photocatalytic coating
Creators: name: Cros, Clement J.
name: Terpeluk, Alexandra L.
name: Crain, Neil E.
name: Juenger, Maria C.G.
name: Corsi, Richard L.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: Nitrogen oxides (NOx) emitted from combustion processes have elevated concentrations in large urban areas. They cause a range of adverse health effects, acid rain, and are precursors to formation of other atmospheric pollutants, such as ozone, peroxyacetyl nitrate, and inorganic aerosols. Photocatalytic materials containing a semi-conductor that can be activated by sunlight, such as titanium dioxide, have been studied for their ability to remove NOx. The study presented herein aims to elucidate the environmental parameters that most influence the NOx removal efficiency of photocatalytic coatings in hot and humid climate conditions. Concrete samples coated with a commercially available photocatalytic coating (a stucco) and an uncoated sample have been tested in a reactor simulating reasonable summertime outdoor sunlight, relative humidity and temperature conditions in southeast Texas. Two-level full factorial experiments were completed on each sample for five parameters. It was found that contact time, relative humidity and temperature significantly influenced both NO and NO2 removal. Elevated concentrations of organic pollutants reduced NO removal by the coating. Ultra-violet light intensity did not significantly influence removal of NO or NO2, however, ultra-violet light intensity was involved in a two-factor interaction that significantly influenced removal of both NO and NO2.Implications: The potential for removal of oxides of NOx in realistic outdoor conditions by a photocatalytic coating (a stucco) applied on concrete was studied through full factorial experimentation. Results suggest that locations offering longer contact time between the pollutant and the reactive surface would lead to greater removal. The presence of elevated relative humidity reduces the NOx removal effectiveness of the coating. Concentrations of organic pollutants in the vicinity of the material did not significantly influence its removal effectiveness, making it potentially suitable as a control strategy for NO2 near roadways, where elevated NO2 levels are observed in combination with volatile organic compounds (VOCs).
H2 optimal signal predictive quantization in oversampled FBs
Creators: name: Li, Shenpeng
name: Zhang, Jingxin
name: Zhang, Cishen
Publisher: name: Swinburne
Year: 2024

description: This paper is concerned with the design of signal predictor in oversampled signal predictive subband coding. Spectral analysis of the prediction error system is used to derive an H2 optimization formulation of the design problem, and an LMI based method is obtained to design the H2 optimal signal predictor that minimizes the variance of quantizer input signals. Simulation examples are presented to demonstrate the obtained design method.
title: Therapeutic efficiency and biomechanical effects of sport insoles in female runners
Creators: name: Baur, Heiner
name: Hirschmüller, Anja
name: Jahn, Michael
name: Müller, Steffen
name: Mayer, Frank
Publisher: name: Universität Potsdam
Year: 2020

description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 624
Frame-theory-based analysis and design of oversampled filter banks: Direct computational method
Creators: name: Chai, Li
name: Zhang, Jingxin
name: Zhang, Cishen
name: Mosca, Edoardo
Publisher: name: Swinburne
Year: 2024

description: This paper studies the frames corresponding to oversampled filter banks (FBs). For this class of FB frames, we present a state-space parameterization of perfect reconstruction FB frames and explicit and numerically efficient formulas to compute the tightest frame bounds, to obtain the dual FB frame, and to construct a tight (paraunitary) FB frame from a given untight (nonparaunitary) FB frame. The derivation uses well-developed techniques from modern control theory, which results in the unified formulas for generic infinite-impulse-response (IIR) and finite-impulse-response (FIR) FBs. These formulas involve only algebraic manipulations of real matrices and can be computed efficiently, reliably, and exactly without the approximation required in the existing methods for generic FBs. The results provide a unified framework for frame-theory-based analysis and systematic design of oversampled filter banks.
Time wave Interference: Virtual Reality Test V001
Creators: name: Kitchen, Kris
Publisher: name: figshare
Year: 2015
Subjects: subject: 20104 Galactic Astronomy
subject: FOS: Physical sciences
subject: Cosmology
subject: Astrophysics
subject: Special Relativity
subject: Applied Physics
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Computational Physics
subject: Atomic Physics
subject: Applied Computer Science
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Computation Theory and Mathematics
subject: Distributed Computing
subject: Data Format
subject: M-Theory
subject: General Relativity
subject: Applied Psychology
subject: Clinical Psychology
subject: Developmental and Educational Psychology
subject: Neuroscience and Physiological Psychology
subject: Organizational Behavioral Psychology
subject: 20203 Particle Physics
subject: Plasma Physics
subject: Condensed Matter Physics
subject: Mechanics
subject: Thermodynamics
subject: Entropy
subject: Quantum Mechanics
subject: 91308 Solid Mechanics
subject: FOS: Mechanical engineering
subject: Personality, Social and Criminal Psychology
subject: Artificial Intelligence and Image Processing
subject: Extragalactic Astronomy

description: Time wave Interference: Virtual Reality Test V001
Genome-wide identification and evolutionary analysis of the FGF gene family in buffalo
Creators: name: Hassan, Faiz-ul
name: Deng, Tingxian
name: Rehman, Muhammad Saif-ur
name: Rehman, Zia-ur
name: Sarfraz, Saad
name: Mushahid, Muhammad
name: Rehman, Saif ur
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Fibroblast growth factors (FGFs) are important polypeptide growth factors that play a critical role in many developmental processes, including differentiation, cell proliferation, and migration in mammals. This study employs in silico analyses to characterize the FGF gene family in buffalo, investigating their genome-wide identification, physicochemical properties, and evolutionary patterns. For this purpose, genomic and proteomic sequences of buffalo, cattle, goat, and sheep were retrieved from NCBI database. We identified a total of 22 FGF genes in buffalo. Physicochemical properties observed through ProtParam tool showed notable features of these proteins including in-vitro instability, thermostability, hydrophilicity, and basic nature. Phylogenetic analysis grouped 22 identified genes into nine sub-families based on evolutionary relationships. Additionally, analysis of gene structure, motif patterns, and conserved domains using TBtools revealed the remarkable conservation of this gene family across selected species throughout the course of evolution. Comparative amino acid analysis performed through ClustalW demonstrated significant conservation between buffalo and cattle FGF proteins. Mutational analysis showed three non-synonymous mutations at positions R103 > G, P7 > L, and E98 > Q in FGF4, FGF6, and FGF19, respectively in buffalo. Duplication events revealed only one segmental duplication (FGF10/FGF22) in buffalo and two in cattle (FGF10/FGF22 and FGF13/FGF13-like) with Ka/Ks values <1 indicating purifying selection pressure for these duplications. Comparison of protein structures of buffalo, goat, and sheep exhibited more similarities in respective structures. In conclusion, our study highlights the conservation of the FGF gene family in buffalo during evolution. Furthermore, the identified non-synonymous mutations may have implications for the selection of animals with better performance. Communicated by Ramaswamy H. Sarma
Influence of environmental factors on removal of oxides of nitrogen by a photocatalytic coating
Creators: name: Cros, Clement J.
name: Terpeluk, Alexandra L.
name: Crain, Neil E.
name: Juenger, Maria C.G.
name: Corsi, Richard L.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: Implications statementThe potential for removal of NOx in realistic outdoor conditions by a photocatalytic coating (a stucco) applied on concrete was studied through full factorial experimentation. Results suggest that locations offering longer contact time between the pollutant and the reactive surface would lead to greater removal. The presence of elevated relative humidity reduces the NOx removal effectiveness of the coating. Concentrations of organic pollutants in the vicinity of the material did not significantly influence its removal effectiveness, making it potentially suitable as a control strategy for NO2 near roadways, where elevated NO2 levels are observed in combination with VOCs.
Mangiferin from Enicostemma littorale Blume with in silico and in vitro anti-inflammatory potential
Creators: name: Kumar, Niraj
name: Tripathi, Nancy
name: Kumar, Sanjeev
name: Kushwaha, Manoj
name: Banerjee, Chiranjib
name: Dey, Swapan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: The bioassay-guided fractionation of the extract of aerial parts of Enicostemma littorale resulted in two fractions 3 and 4 with moderate and potent antioxidant activity, respectively. The purification of fraction 3 gave swertiamarin (1), while the LCMS profile of fraction 4 unveiled the presence of another constituent along with swertiamarin. The extensive purification of fraction 4 led to the unusual isolation of mangiferin (2) from E. littorale. The uncommon isolation of mangiferin from E. littorale motivated us to conduct its in silico and in vitro screening as an anti-inflammatory agent. Both studies have proved mangiferin to be a promising anti-inflammatory molecule with a binding energy of −9.17 kcal/mol against Cyclooxygenase-2 protein and IC50 of 146.07 nanomolar. This study is the first report of the isolation of mangiferin, a xanthone glycoside from E. littorale. Communicated by Ramaswamy H. Sarma
Tissue distribution and persistence of malachite green and leucomalachite green in common carp. Medycyna Weterynaryjna 2008, 64 (8), 1055-1058
Creators: name: Mitrowska, Kamila
name: Posyniak, Andrzej
name: Zmudzki, Jan
Publisher: name: figshare
Year: 2015
Subjects: Pharmacology

description: Malachite green (MG) is a synthetic triphenylmethane dye, which has been used worldwide as fungicide and ectoparasicide in cultured fish eggs, fingerlings and adult fish since 1930s. Due to its potential animal carcinogenicity, mutagenity and teratogenicity, MG is not registered for veterinary use in many countries including the European Union. The aim of this study was to investigate the tissue distribution and persistence of MG and its main metabolite, leucomalachite green (LMG), in carp after therapeutic bath. On day 0, MG concentration in all tissues exceeded the initial concentration in therapeutic water (2 mg/l). The dye was thereafter rapidly and extensively metabolized to LMG, which was slowly eliminated from the tissues. Higher concentrations of MG and LMG were detected in gill, liver and kidney than in the spleen and muscle. The parent compound was more persistent in kidney, liver and spleen (up to 112 days) than in gill and muscle (up to 56 days). LMG concentrations declined more slowly in all tissues being still detectable in kidney and muscle 252 days after treatment.
Insight into novel inhibitors from Sterculia urens against Cholera via pharmacoinformatics and molecular dynamics simulation approaches
Creators: name: Rahman, M. Oliur
name: Ahmed, Sheikh Sunzid
name: Alqahtani, Ali S.
name: Cakilcioğlu, Uğur
name: Akbar, Mohammad Ahsanul
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The underdeveloped countries with large populations are facing a grave global threat in the form of cholera. Vibrio cholerae, the etiologic agent of Cholera has drawn attention recently due to antimicrobial resistance and resulting outbreaks that necessitates establishment of novel medications to counteract virulence and viability of the pathogen. Sterculia urens Roxb. (Malvaceae) is an ethnomedicinally important tree, which harbors a good number of bioactive phytocompounds. In the present study, 53 phytocompounds of S. urens were screened against the promising target ToxT of V. cholerae employing structure-based drug design approach that revealed three lead compounds, viz., 4,4,5,8-Tetramethylchroman-2-ol (−8.2 kcal/mol), Beta-Bisabolol (−8.2 kcal/mol) and Ledol (−8.7 kcal/mol) with satisfactory ADMET properties. Molecular dynamics simulation for 150 ns unveiled notable compactness and structural stability for the lead compounds considering RMSD, RMSF, Rg, MolSA, PSA and protein-ligand contacts parameters. Molecular mechanics-based MM/GBSA binding energy calculation revealed Beta-Bisabolol (−66.74 kcal/mol) to have better scores than 4,4,5,8-Tetramethylchroman-2-ol (−47.42 kcal/mol) and Ledol (−65.79 kcal/mol). Enzymes were mostly found as drug target class, and Nabilone was found as a structurally similar analog for 4,4,5,8-Tetramethylchroman-2-ol. These discoveries could aid in revealing new antibacterial medications targeting ToxT to combat Cholera. Communicated by Ramaswamy H. Sarma
Reasons and consequences of the ban on the use of 5-nitroimidazoles in food producing animals. Medycyna Weterynaryjna 2015 (accepted manuscript)
Creators: name: Mitrowska, Kamila
Publisher: name: figshare
Year: 2015
Subjects: Toxicology

description: Nitroimidazoles have been used for the treatment of anaerobic bacterial and parasitic infections in animals. However, they are believed to possess genotoxic and carcinogenic properties, and this is why their use in food producing animals has been banned in many countries. At present, nitroimidazoles are approved in the European Union to use only in companion animals and human medicine although the reason for the ban of their use in food producing animals was just care about the health of the people. As a consequence of this ban each European Union country and countries wishing to export animal products to the European Union are required to implement a residue monitoring plan for nitroimidazole residues in food of animal origin which helps to ensure the safety and reduce the possible health risks to consumers. In this article the pharmacological and toxicological aspects of the most commonly used 5-nitroimidazoles in veterinary medicine are summarized.
Tissue distribution and persistence of malachite green and leucomalachite green in common carp (in Polish)
Creators: name: Mitrowska, Kamila
name: Posyniak, Andrzej
name: Zmudzki, Jan
Publisher: name: figshare
Year: 2015
Subjects: Pharmacology

description: Malachite green (MG) is a synthetic triphenylmethane dye, which has been used worldwide as fungicide and ectoparasicide in cultured fish eggs, fingerlings and adult fish since 1930s. Due to its potential animal carcinogenicity, mutagenity and teratogenicity, MG is not registered for veterinary use in many countries including the European Union. The aim of this study was to investigate the tissue distribution and persistence of MG and its main metabolite, leucomalachite green (LMG), in carp after therapeutic bath. On day 0, MG concentration in all tissues exceeded the initial concentration in therapeutic water (2 mg/l). The dye was thereafter rapidly and extensively metabolized to LMG, which was slowly eliminated from the tissues. Higher concentrations of MG and LMG were detected in gill, liver and kidney than in the spleen and muscle. The parent compound was more persistent in kidney, liver and spleen (up to 112 days) than in gill and muscle (up to 56 days). LMG concentrations declined more slowly in all tissues being still detectable in kidney and muscle 252 days after treatment.