cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Two polyphenols with diverse mechanisms towards amyloidosis: differential modulation of the fibrillation pathway of human lysozyme by curcumin and EGCG
Creators: name: Zaidi, Fatima Kamal
name: Bhat, Rajiv
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The effect of two widely used polyphenols, curcumin and EGCG was investigated on the amyloid fibrillogenesis of the well-characterized model protein human lysozyme (HuL), associated with non-neuropathic systemic amyloidosis, towards exploring their efficacy as modulators of HuL amyloid aggregation and toxicity and unravelling their mechanism of action. Curcumin exerts its inhibitory influence towards HuL fibrillation by interacting with the prefibrillar and fibrillar intermediates resulting in complete suppression of fibrillation at ∼200 µM and effectively disaggregates preformed fibrils of HuL. EGCG on the other hand suppresses fibrillation only upto 70% at ∼400 µM, modulates the pathway towards large, β-sheet rich amyloid fibril-like aggregates and modifies the preformed fibrils into similar type of large, clustered aggregate assemblies. The overall surface hydrophobicity and cytotoxicity of HuL is significantly reduced not only in the presence of curcumin but also EGCG, despite the latter forming large agglomerates, which could be accounted for by the dense and highly clustered nature of aggregates rendering their surface less exposed and thus less amenable to interact with cellular entities thereby causing reduced cellular toxicity. This study highlights the differential mechanisms employed by curcumin and ECCG in modulating the fibrillation pathway of HuL and illustrates the importance of overall modulation of fibrillation towards a general reduction in toxicity, rather than specifically focusing only on inhibition of fibrillation. This study also demonstrates how two widely different polyphenols employ disparate mechanisms to modulate the fibrillation pathway of a single protein and yet converge towards a common effect of alleviation of cytotoxicity.
Mitofsky International Poll # 1994-NATELEC: National Election Exit
Creators: name: Mitofsky International
Publisher: name: Roper Center for Public Opinion Research
Year: 2011

description: Factors and issues in deciding House vote (2); Bill Clinton's effect on House vote (1); Senator and Governor vote (2); 1992 presidential vote (1); Clinton job performance (3); women in public office (1); new faces vs. experience in Congress (1); country on right or wrong track (1); confidence in government (1); president and Congress of the same or different parties (1); Clinton at mid-term (1).
NBC News/Wall Street Journal Poll: June, 2009--Recession/Automobile Industry/Health Care
Creators: name: NBC News
name: Wall Street Journal
Publisher: name: Roper Center for Public Opinion Research
Year: 2009

description: Direction of country (1); confidence in future generations (1); Barack Obama job performance (1); Barack Obama handling issues (2); Congressional job performance (1); Opinion of public figures (9); Ben Bernanke as Federal Reserve Board Chairman (1); federal government addressing issues (2); opinion of Barack Obama (8); role of government (1); Sonia Sotomayor (4); satisfaction with economy (1); financial situation (1); economic outlook (1); economic recession (1); economic issues (1); views on president and congress (1); Obama inheriting economic conditions (1); economic stimulus (1); federal budget deficit (1); quality of cars produced (4); buying American car (2); government aid to American automakers (2); Barack Obama's health care plan (3); President/Congress focus on health care (1); health care coverage (1); funding health care plan (6); health care choices (1); likelihood of employer dropping insurance for public option (1); opinion on public health plan (1); Russia (1); Muslims (1); Muslim/American relations (1); North Korea (1); affirmative action (1).
Empirical Analysis of ANN in Pricing Options
Creators: name: Qingcheng Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: The Black-Scholes-Merton (BSM) model and stochastic volatility models like the Heston model
have been extensively used in financial markets over the past decades. Recently, alternative
methods such as Artificial Neural Network (ANN) models have been developed to price the
European vanilla options. These models aim to leverage parameters from both traditional models
to create fast and accurate solutions for analyzing option data. In this research, we delve deeper
into this area by designing and fine-tuning a Multilayer Perceptron (MLP) model, which we
apply to American option data : real-time S&P 500 (SPX) option data from a recent month.
We compare the performance of our MLP model against traditional models, discussing some
limitations in prediction accuracy. Additionally, we explore the impact of incorporating volatility
measurements on the predictive capabilities of our model. For the Heston model, we generated
data and utilized the COS (Fourier-cosine series) method in conjunction with the ANN to test the
efficacy of the ANN model in predicting option prices. This approach allows us to assess the
practicality and effectiveness of neural networks in capturing complex financial dynamics
beyond the scope of conventional models.
Identification of potent human carbonic anhydrase IX inhibitors: a combination of pharmacophore modeling, 3D-QSAR, virtual screening and molecular dynamics simulations
Creators: name: Chahal, Varun
name: Nirwan, Sonam
name: Pathak, Mallika
name: Kakkar, Rita
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Human carbonic anhydrase IX (hCA IX) is a promising target for the development of potential anticancer agents. In the current study, pharmacophore and 3D-QSAR models have been developed using SLC-0111 derivatives. The developed models have been further utilized for the virtual screening process to develop potent hCA IX inhibitors. Thirteen different models have been developed by employing various combinations of training and test set molecules. Based on this, a model, AADDR.135, comprising two H-bond acceptors, two H-bond donors and one aromatic ring, has been found as the best QSAR model. The proposed model exhibits high robustness (R2 = 0.9789), with good predictive ability (Q2 = 0.6872). An external library of drug-like compounds (∼10000 molecules) imported from the ZINC15 database has been screened over the model AADDR.135. In total, 1601 compounds were obtained as hits. Molecular docking studies and molecular dynamics simulations have been performed on the obtained hits and, based on these computations, two unique molecules have been identified as potential hCA IX inhibitors. These show higher binding energies compared to the parent molecule and its most potent analogue. Communicated by Ramaswamy H. Sarma
VRS 1992 Arkansas Election Day Exit Poll
Creators: name: ABC News
name: CBS News
name: CNN
name: NBC News
Publisher: name: Roper Center for Public Opinion Research
Year: 1993

description: 1992 presidential election(1); national economy(1); 1988 presidential election(1); job performance of Governor Bill Clinton(1); 1992 senatorial election(1); Senator Dale Bumper job performance(1).
ABC News/Washington Post Poll: Politics, Federal Spending and Religion
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2014

description: Bill Clinton job performance (4); Clinton versus Republicans in Congress (9); cuts in spending to reduce deficit (18); Newt Gingrich book deal (4); term limits (1); minimum wage (1); OJ Simpson (3); airline safety (5); religion (3); religious beliefs (8); baseball strike (10).
Binding of Folate-G4-PAMAM dendrimer conjugate with indomethacin via ligand diffusion MD simulations
Creators: name: Martínez-Muñoz, Alberto
name: Correa-Basurto, José
name: Bello, Martiniano
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Preceding experimental findings revealed that the release of indomethacin decreased when a folate conjugate G4-PAMAM (folate-G4-PAMAM) dendrimer was used compared with its unconjugated dendrimer (G4-PAMAM). Further, better encapsulation of the conjugated dendrimer was achieved, information useful for elucidating the structural and energetic basis of indomethacin on folate-G4-PAMAM encapsulation. In this study, we employed a ligand diffusion molecular dynamic simulations (LDMDSs) strategy combined with the molecular mechanics-generalized-born surface area (MMGBSA) approach to explore the mechanism by which indomethacin conjugated to folate-G4-PAMAM dendrimer forms complexes better than G4-PAMAM dendrimer. To this, we first constructed and equilibrated the folate-G4-PAMAM dendrimer, then, this system was submitted to docking and molecular dynamics (MD) simulation to evaluate its ability to form a stable complex with the folate receptor (FR). We observed that the folate-G4-PAMAM dendrimer was able to bind FR with higher affinity than free folic acid. Based on these results, we further performed LDMDSs to assess folate-G4-PAMAM dendrimer and G4-PAMAM dendrimer contacts with indomethacin. Our results correlate with experimental data, which confirm that folate-G4-PAMAM dendrimers are capable of most rapidly binding greater numbers of indomethacin molecules than G4-PAMAM, which suggests better loading and slower release occurs when the functionalized G4-PAMAM dendrimer is used. The simulations further revealed that van der Waals interactions govern the affinity. Communicated by Ramaswamy H. Sarma
Additional file 1 of Harnessing energy abundance: sustainable expansion of solar parks in Lower Saxony through harmonized spatial planning
Creators: name: Badelt, Ole
name: Wiehe, Julia
name: von Haaren, Christina
Publisher: name: figshare
Year: 2025
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1. Geodata used in the analysis and classification of their spatial resistance classes. The data contains a detailed description of geodata used in the analysis and an explanation of their classification into spatial resistance classes according to sensitivity, value, legitimacy and specificity.
title: Einflussfaktoren auf das Rauchverhalten von AHS-SchülerInnen
Creators: name: Rainer, Johannes
Year: 2021

description: In dieser Diplomarbeit wurde untersucht, welche Faktoren sich auf das Rauchverhalten von Jugendlichen auswirken. Das Ziel dieser Arbeit war, neben einer Zusammenfassung des aktuellen Forschungsstands im Zuge einer empirischen Untersuchung die Zusammenhänge sowie deren Größe zwischen Meinungen, Lebensumständen sowie dem Gesundheitsbewusstsein der ProbandInnen und deren Konsumverhalten zu erfassen. Zu diesem Zweck wurden Schülerinnen im Alter von 13 bis 19 Jahren an vier Wiener Gymnasien befragt. Die Erhebung der Daten erfolgte mittels eines Fragebogens, der 170 Items umfasst, die sich zum Großteil aus Likert-Skalen sowie Multiple Choice – Fragen zusammensetzen. Insgesamt konnten 434 gültige Fragebögen in die Analyse einfließen. Zum Zweck der statistischen Auswertung wurden die SchülerInnen nach ihrem Konsumverhalten in vier ordinalskalierte Gruppen eingeteilt. Die Studie zeigt, dass in dieser Stichprobe Neugier, der Geschmack sowie die Wirkung gegen Stress die wichtigsten Beweggründe für den Tabakkonsum darstellen, während bei regelmäßigen RaucherInnen vor allem eine mittels Faktoranalyse ermittelte emotionale Komponente für das Konsumverhalten verantwortlich ist. Zudem unterscheiden sich regelmäßige und gelegentliche RaucherInnen hinsichtlich ihrer Entzugserscheinungen, wobei unruhige Gefühle dominieren. Hinsichtlich finanzieller Aspekte weist die Höhe des Taschengelds eine höchst signifikante Assoziation mit dem Rauchverhalten auf, nicht jedoch die Beurteilung des Zigarettenpreises. Als wichtigste Faktoren im Hinblick auf das soziale Umfeld stellen sich im Einklang mit der Literatur das Konsumverhalten des/der beste(n) FreundIn sowie des/der BeziehungspartnerIn dar, gefolgt von der Erlaubnis, zuhause rauchen zu dürfen. Rauchverbote in der Schule sowie das Rauchverhalten der Eltern unterschreiten jedoch nicht die Signifikanzgrenze. 8 In Bezug auf das Gesundheitsbewusstsein korreliert die Einschätzung der Gefahr des aktiven Tabakkonsums erwartungsgemäß negativ mit dem Konsumverhalten, wohingegen sich kein Zusammenhang zwischen letzterem und der Einschätzung des Abhängigkeitspotentials, des Entstehungsrisikos von Krankheiten und der Wahrnehmung von Warnhinweisen in einer abschließenden Regression zeigt.
In-silico screening of bioactive phytopeptides for novel anti-ageing therapeutics
Creators: name: Salekeen, Rahagir
name: Ahmed, Asif
name: Islam, Md Emdadul
name: Billah, Md Morsaline
name: Rahman, Hafizur
name: Islam, Kazi Mohammed Didarul
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: A metabolic network of energy-sensing molecular pathways drives the biological ageing process. Regulating certain network elements can help decelerate the ageing process and ameliorate ageing associated disorders. Bioactive phytopeptides are a prospective avenue for anti-ageing therapeutics and rejuvenation biotechnology. The present study investigates the potential of therapeutic plant peptides against cellular senescence by targeting three key proteins in the ageing network – target of rapamycin (mTOR), adenosine monophosphate-activated protein kinase (AMPK) and sirtuin 1 (SIRT1). This investigation screened a library of reported bioactive peptides using standard cheminformatic methods including in-silico ADMET, molecular docking, molecular dynamics simulation and molecular mechanics calculation. The retrieved simulation data predict 25 diverse phytopeptides as potential safe and drug-like anti-ageing biologics with half-lives >20 h and bioavailability scores >0.40. The best docked peptide, Cycloleonuripeptide B, exhibited strong binding affinity and stable complex formation with mTOR (-17.5 kCal/mol), SIRT1 (-28.54 kCal/mol) and two active sites in AMPK (-41.8 kCal/mol; −36.0 kCal/mol) during molecular dynamics simulations. The computational study acts as a foundation for future laboratory and clinical research into the potential of repurposing therapeutic phytopeptides against cellular senescence and associated pathophysiology. Communicated by Ramaswamy H. Sarma
[Drei auf einer Bank]
Creators: name: Breitinger, Robert
Publisher: name: [Robert Breitinger]
Year: 1897
Subjects: Mann

description: Drei unbekannte Männer sitzen auf einer Bank, im Hintergrund erkennt man die Doppelsäulen vom Zentralhof
description: [Robert Breitinger]
description: Bildtitel gemäss Zettelkatalog der Graphischen Sammlung und des Fotoarchivs und dem Verzeichnis Breitingers
description: Auf der Rückseite oben links Vermerk mit roter Tinte: "4088" (Bildnummer der Visitenkarte). Gemäss dem Verzeichnis Breitingers wurde die Fotografie vermutlich am 27. Mai 1897 aufgenommen
description: Aus der Sammlung Breitinger (1841-1913) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
NBC News/Wall Street Journal Poll: July, 2009--Congress/Health Care
Creators: name: NBC News
name: Wall Street Journal
Publisher: name: Roper Center for Public Opinion Research
Year: 2009

description: Direction of country (1); Barack Obama job performance (4); Congressional job performance (2); opinion of public figures (10); Congressional preference (1); issues (2); confidence in Barack Obama (4); rating Barack Obama (9); Obama proposals (2); Obama handling presidency (1); Sonya Sotomayor nomination (1); parties handling issues (11); goals of Congress (4); criticisms of congress (1); government partisanship (2); economic satisfaction (1); economic outlook (1); job security (1); views of congress (1); economic stimulus (3); economic conditions (1); health care (2); health care legislation (1); public health care (1); health insurance (1); Obama health care plan (1); funding public health care (6); CIA assassins in Al Qaeda (1); possible presidential candidates (2); arrest of Henry Louis Gates (1).
Biology Of Epitrix (Flea Beetle) And Techniques For Detection
Creators: name: Cuthbertson Andrew
Publisher: name: Zenodo
Year: 2015
Subjects: Euphresco, Epitrix, biology, management, attractants, diagnostics, morphological identification key, real-time PCR

description: Success story of the Euphresco project 'Epitrix (flea beetle) species, life cycles and detection method'
description: Project funded through the EUPHRESCO ERA-NET
VRS 1992 Arizona Election Day Exit Poll
Creators: name: ABC News
name: CBS News
name: CNN
name: NBC News
Publisher: name: Roper Center for Public Opinion Research
Year: 2018

description: 1992 presidential election(2); abortion(1); term limits(1); 1992 U.S. senatorial election(3); Martin Luther King Jr. Day(2); national economy (1); 1988 presidential election(1).
Sonnenfleckenzeichnung L-Nr. 2429.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.07.1947, erstellt als Beobachtung im Projektionsverfahren Nr. 833 von Karl Rapp in Locarno-Monti
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1947

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Merz-Refraktor mit 13.5 cm Öffnung und 195 cm Brennweite, vereinzelt andere Instrumente wie Tel. 88x; Sonnenbild D = 25 cm. - Auf der Zeichnung wird zum Teil das Instrument vermerkt bzw. die Zählung der Beobachtungen im Projektionsverfahren fortgesetzt. Sporadisch sind Resultate mehrerer Aufnahmen pro Tag aufgelistet. Zuhanden der späteren statistischen Verarbeitung sind die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Zeichnung aus der Zeit der Beobachtertätigkeit von Ing. Karl Rapp als Privat-Astronom, die er seit den Neunzehnvierziger Jahren für die Eidgenössische Sternwarte Zürich ausführte. Aus den ersten zwei Jahren der freiwilligen Mitarbeit sind nur einzelne Stücke überliefert. Erst zwei Jahre später ist jeweils eine ergänzende Serie in Zürich aufbewahrt worden. Nochmals fünf Jahre später arbeitete Karl Rapp neu auf vertraglicher Basis weiter mit, bis schliesslich nach einem weiteren Jahrzehnt die permanente Beobachtungsstation in Locarno-Monti geschaffen wurde, welche an die langjährige Serie von Karl Rapp anknüpfte
Cone-beam CT during TACE: an useful tool!
Creators: name: Pozzi Mucelli, Fabio
Publisher: name: EURORAD
Year: 2016
Subjects: subject: Abdomen
subject: Interventional vascular
subject: Liver
subject: Vascular
subject: CT
subject: CT-Angiography
subject: Catheter arteriography
subject: Ultrasound
subject: Ablation procedures
subject: Chemoembolisation
subject: Diagnostic procedure
subject: Neoplasia

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 62 years
description: Clinical History: Male, 62 yo. Well-compensated exotoxic chronic liver disease. Diabetes Mellitus. In December 2015 a CT scan revealed a 2.3 cm HCC nodule on the fourth segment (Fig. 1a-c). Due to low visibility at US investigation and to the unfavourable site for thermal ... Final Diagnosis: Hepatocellular carcinoma
Uterine artery pseudoaneurysm : A rare life threatening cause of secondary post partum haemorrhage
Creators: name: NADARAJAN, SREERAJ
Publisher: name: EURORAD
Year: 2016
Subjects: subject: Genital / Reproductive system female
subject: CT-Angiography
subject: Catheter arteriography
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Spectral Doppler
subject: Embolisation
subject: Aneurysms

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 26 years
description: Clinical History: A 26-year-old female who delivered a 2800g male baby was admitted with excessive bleeding per vaginum. She underwent elective C-section 5 weeks back. O/E she was hypotensive, anaemic (Hb 3.8), abdomen was soft with healthy scar. Uterus bulky, os closed. B... Final Diagnosis: Left uterine artery pseudoaneurysm
Additional file 1 of Structural features of somatic and germline retrotransposition events in humans
Creators: name: Nummi, Päivi
name: Cajuso, Tatiana
name: Norri, Tuukka
name: Taira, Aurora
name: Kuisma, Heli
name: Välimäki, Niko
name: Lepistö, Anna
name: Renkonen-Sinisalo, Laura
name: Koskensalo, Selja
name: Seppälä, Toni T.
name: Ristimäki, Ari
name: Tahkola, Kyösti
name: Mattila, Anne
name: Böhm, Jan
name: Mecklin, Jukka-Pekka
name: Siili, Emma
name: Pasanen, Annukka
name: Heikinheimo, Oskari
name: Bützow, Ralf
name: Karhu, Auli
name: Burns, Kathleen H.
name: Palin, Kimmo
name: Aaltonen, Lauri A.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional File 1: Additional methods and additional figures.
NBC News/Wall Street Journal Poll: September, 2009--Government/Economy/Health Care/Afghanistan
Creators: name: NBC News
name: Wall Street Journal
Publisher: name: Roper Center for Public Opinion Research
Year: 2010

description: Direction of country (1); Barack Obama job performance (2); Obama handling issues (3); Congressional job performance (1); opinion of public figures (5); preference for congressional elections (1); reelecting congressional representatives (1); issues proposed for government to address (14); opinion of government (1); opinion of Barack Obama (1); confidence in Obama's goals (2); partisanship in Washington (1); Republicans handling health care reform (1); health care debate in Congress (1); opinion of health care legislation (1); satisfaction with economy (1); opinion of economy (1); job security (1); economic stimulus legislation (3); economic indicators (1); views on President and Congress (1); economic conditions (1); Obama's health care plan (3); goals of health care reform (1); public vs. private health care options (1); favoring federal health care option (1); personal health care coverage (1); health care reform legislation (5); benefits of changes to health care system (1); concerns over changes in health care system (1); blame for failure to pass healthcare reform (1); success of war in Afghanistan (2); withdrawing troops from Afghanistan (2); investing money in war in Afghanistan (1); U.S. relations with Afghanistan (1); race relations (1).
NBC News/Wall Street Journal Poll: October, 2009--Barack Obama/Health Care Reform
Creators: name: NBC News
name: Wall Street Journal
Publisher: name: Roper Center for Public Opinion Research
Year: 2009

description: Direction of country (1); Barack Obama job performance (1); Barack Obama handling issues (3); Congressional job performance (1); Congressional Republicans handling health care reform (1); rating public figures (10); Congressional elections (2); role of government (1); trusting government (1); relating to Barack Obama (1); feelings of Barack Obama (1); rating Obama on certain qualities (14); new independent political party (1); partisanship and cooperation (2); state of economy (1); economic outlook (2); Obama involvement in economic problems (1); economic stimulus (2); unemployment (1); increase in Dow Jones (1); Obama's health care plan (4); reforming health care system (1); focusing health care issues (2); goals of healthcare (1); personal health care coverage (1); federally run public health plan (2); passing health care bill (1); blame for delaying health care bill (4); Afghanistan (7); Iran (1); global warming (2); abortion (1); gay marriage (1); sale of guns (1); legalizing marijuana (1).
Analyzing the Viability of Natural Language Processing for Propaganda Classification Within the Context of the Russia-Ukraine war.
Creators: name: Martin Santiago
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: In this project, I analyze the viability of implementing an NLP model to diagnose propaganda
within the context of the Russia-Ukraine war. To do so, I take two corpora of manually coded
articles (one propagandistic and one non-propagandistic). I then run two tests with different
confidence thresholds and compare the false positives/misclassifications between both corpora.
Here I find two different results, with the less strict threshold of 0.5 validating the model but the
more strict thresholds of 0.25 and 0.75 being unable to do so. Furthermore, I use the TPD Article
Analysis Tool to qualitatively understand the limitations of the model. I conclude based on the
analysis that NLPs are not yet broadly applicable without human oversight but that rapid
developments in the field are grounds to be optimistic about the future
USIA Poll # 1988-I88099: Australia-US Relations
Creators: name: USIA
Publisher: name: Roper Center for Public Opinion Research
Year: 2009

description: Threats to Australia (2); peace and stability in Pacific Islands (5); opinion of certain countries (4); confidence in other countries (3); nuclear arms control (2); Soviet nuclear threat (1); policies linked with United States (1); ANZUS Treaty (4): joint defense facilities (3); American warships in Australian ports (2); influence in Australian economy (1); other countries effecting trade/economy (3); country to buy Australian agriculture (2); policy similarities (2); agricultural policy (2); American/Australian agricultural trade (4); Australia close ally of America (1); partisan opinion (1).
ABC News/Washington Post Poll: First 100 Days of Congress
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2014

description: Bill Clinton job performance (1); performance of political leaders and institutions (6); Republicans in Congress (9); Clinton versus Republicans in Congress (5); Contract with America (3); Congressional job performance (9); Clinton and Newt Gingrich characteristics (10); knowledge of House of Representative actions (8); child tax credits (2);1992 election (3).
Comparison of polyphenols composition between red and white wines of some native Campania region grape varieties
Creators: name:  MASULLO, Mariorosario; ARCONE Rosaria; D’ANGELO Stefania; GELZO Monica; CORSO  Gaetano; DELLO RUSSO Antonio
Publisher: name: International Society of Antioxidants in Nutrition and Health (ISANH)
Year: 2017

description: In this work, we have determined and compared polyphenols and elements compositions of four wines obtained from native Campania region white grape varieties (Greco di Tufo, n = 32; Fiano di Avellino, n = 35) and red grape varieties (Taurasi, n = 15; Irpinia Aglianico, n = 10). The obtained results point to a higher content of resveratrol in red wines than in white ones and a higher levels of other healthy polyphenols, such as coumaric, ferulic and caffeic acid in white wines.
description: Archives of ISANH: Vienna Polyphenols 2017
Additional file 2 of Structural features of somatic and germline retrotransposition events in humans
Creators: name: Nummi, Päivi
name: Cajuso, Tatiana
name: Norri, Tuukka
name: Taira, Aurora
name: Kuisma, Heli
name: Välimäki, Niko
name: Lepistö, Anna
name: Renkonen-Sinisalo, Laura
name: Koskensalo, Selja
name: Seppälä, Toni T.
name: Ristimäki, Ari
name: Tahkola, Kyösti
name: Mattila, Anne
name: Böhm, Jan
name: Mecklin, Jukka-Pekka
name: Siili, Emma
name: Pasanen, Annukka
name: Heikinheimo, Oskari
name: Bützow, Ralf
name: Karhu, Auli
name: Burns, Kathleen H.
name: Palin, Kimmo
name: Aaltonen, Lauri A.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional File 2: Sequence details of 5′-inverted Alu.
[Halbmedaillon der Rosette im südlichen Querarm der Kathedrale Notre-Dame in Lausanne]
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1860
Subjects: Glasmalerei
Lausanne

description: Die Glasmalereien der Rosette stammen aus dem 13. Jahrhundert, dargestellt wird ein Halbmedaillon, das ein Medaillon mit einem der Paradiesflüsse begleitet: ein Vieräugiger mit dem Beinamen Tetracoli
description: [Johann Rudolf Rahn]
description: Die Zeichnung ist vermutlich eine Vorlage zur Abbildung in: Johann Rudolf Rahn, Die Glasgemälde in der Rosette der Kathedrale von Lausanne. Ein Bild der Welt aus dem XIII. Jahrhundert, Zürich: Orell Füssli & Co, 1879, Tafel VII
description: Johann Rudolf Rahn hat die Farbgebung des Halbmedaillons handschriftlich notiert
description: Aus dem Nachlass Johann Rudolf Rahn Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
Mitofsky International Poll # 1994-STELEC-NJ: New Jersey State Election Exit
Creators: name: Mitofsky International
Publisher: name: Roper Center for Public Opinion Research
Year: 1995

description: U.S. Senate vote(5); Christine Todd Whitman job performance(1); standard of living(1); Clinton job performance(1); 1992 Presidential election(1); party affiliation(2); opinion of candidates favoring stricter punishment(1); direction of state(1); 1988 election for U.S. Senate(1); taxes and state services(1).
USIA Poll # 1989-I89064: Australia Alliance/Australian-American Relations
Creators: name: USIA
Publisher: name: Roper Center for Public Opinion Research
Year: 2009

description: United States (2); Soviet Union (2); Mikhail Gorbachev (1); George Bush (1); arms control (2); U.S. military presence (1); U.S. Alliance (1); U.S. military aid (1); joint military defense facilities (3); U.S. military ships in Australian ports (2); agriculture and trade (6); defense facilities as bargaining chip (1).
Fluid Inclusion Analysis and Deformation History of Ordovician Calcareous Turbidites
Creators: name: Geouque, Emiley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: The Sevier Shale outcrop located on Holston Mountain outside of Elizabethton, Tennessee is an outcrop of Ordovician calcareous turbidites and is characterized by several generations of calcite veins, both bedding-parallel and bedding-perpendicular. The relative ages of these veins are difficult to determine as the veins are isolated and do not cross. Fluid inclusion analysis provides accurate trapping temperatures and pressures and allows for relative dating between various veins. Previous estimates of burial depths estimate this outcropping to have been deformed at depths of 2-3 km (Ohlmacher et al., 1997). Fluid inclusion analyses using these temperatures yielded unrealistic geothermal gradients of approximately 100 ºC/km. Extrapolation from the isochores using a realistic geothermal gradient of 30 ºC/km yields burial depth of 11 km which more closely aligns with the structures seen in the field, as cleavage does not form at 2-3 km. Fluid-inclusion analysis paired with field analysis suggests that bedding-parallel veins formed after deposition during a period of horizontal shortening prior to folding at temperatures of 310 ºC to 339 ºC and pressures of 2600 bars to 2900 bars. A folding event occurred with temperatures of around 310 ºC to 340 ºC and 2800 bars to 2900 bars, and after the stresses from this event relaxed, bedding-perpendicular veins formed at temperatures of 249 ºC to 328 ºC and pressures of 2150 bars to 2800 bars.
Additional file 3 of Structural features of somatic and germline retrotransposition events in humans
Creators: name: Nummi, Päivi
name: Cajuso, Tatiana
name: Norri, Tuukka
name: Taira, Aurora
name: Kuisma, Heli
name: Välimäki, Niko
name: Lepistö, Anna
name: Renkonen-Sinisalo, Laura
name: Koskensalo, Selja
name: Seppälä, Toni T.
name: Ristimäki, Ari
name: Tahkola, Kyösti
name: Mattila, Anne
name: Böhm, Jan
name: Mecklin, Jukka-Pekka
name: Siili, Emma
name: Pasanen, Annukka
name: Heikinheimo, Oskari
name: Bützow, Ralf
name: Karhu, Auli
name: Burns, Kathleen H.
name: Palin, Kimmo
name: Aaltonen, Lauri A.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional File 3: Sequence details of Somatic L1 insertion with sequence from nanopore analysis and Sanger sequencing.
U.S.I.A. survey: Australia Alliance
Creators: name: USIA
Publisher: name: Roper Center for Public Opinion Research
Year: 1998

description: Military threats to Australia(18); strongest country economically(2); U.S. influence in Pacific Region(4); Soviet and U.S. ability to solve problems(2); opinion of Mikhail Gorbachev(1); opinion of George Bush(1); U.S. and Australian relations(3); ANZUS treaty(3); American nuclear weapons in Australia(3); economy(4); agricultural export and production(3); world trade talks in Brussels(1); Persian Gulf crisis(3); political ideology(1).
1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
Creators: name: Koçyiğit, Ümit M.
name: Taslimi, Parham
name: Tüzün, Burak
name: Yakan, Hasan
name: Muğlu, Halit
name: Güzel, Emre
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, cancer, and Alzheimer's. In this manner, the preparation and enzyme inhibition activities of peripherally 1,2,3-triazole group substituted metallophthalocyanine derivatives with strong absorption in the visible region were presented. These novel metallophthalocyanine derivatives (2-6) effectively inhibited AChE, with Ki values in the range of 40.11 ± 5.61 to 78.27 ± 15.42 µM. For α-glycosidase, the most effective Ki values of compounds 1 and 2 were with Ki values of 16.11 ± 3.13 and 18.31 ± 2.42 µM, respectively. Also, theoretical calculations were investigated to compare the chemical and biological activities of the ligand (1) and its metal complexes (2–6). Biological activities of 1 and its complexes against acetylcholinesterase for ID 4M0E (AChE) and α-glycosidase for ID 1R47 (α-gly) are calculated. Theoretical calculations were compatible with the experimental results and these 1,2,3-triazole substituted phthalocyanine metal complexes were found to be efficient inhibitors for anticholinesterase and antidiabetic enzymes. Communicated by Ramaswamy H. Sarma
Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis
Creators: name: Sharma, Aditya
name: Saini, Manisha
name: Kundu, Suman
name: Thelma, B. K.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The ARL15 gene (ADP ribosylation factor like protein 15) encodes for an uncharacterized small GTP-binding protein. Its exact role in human physiology remains unknown, but a number of genetic association studies have recognised different variants in this gene to be statistically associated with numerous traits and complex diseases. We have previously reported a novel association of ARL15 with rheumatoid arthritis (RA) based on a genome-wide association study in a north Indian cohort. Subsequent investigations have provided leads for its involvement in RA pathophysiology, especially its potential as a novel therapeutic target. However, the absence of an experimentally determined tertiary structure for ARL15 significantly hinders the understanding of its biochemical and physiological functions, as well as development of potential lead molecules. We, therefore, aimed to derive a high quality, refined model of the three dimensional structure of human ARL15 protein using two different computational protein structure prediction methods – template-based threading and ab initio modelling. The best model each from among the five each derived from both the approaches was selected based on stringent quality assessment and refinement. Molecular dynamics simulations over long timescales revealed the ab initio model to be relatively more stable, and it marginally outperformed the template-based model in the quality assessment as well. A putative GTP-binding site was also predicted using homology for the ARL15 protein, where potential competitive inhibitors can be targeted. This high quality predicted model may provide insights to the biological role(s) of ARL15 and inform and guide further experimental, structural and biochemical characterization efforts. Communicated by Ramaswamy H. Sarma
ABC News/Washington Post Poll: 1996 Election
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2014

description: Bill Clinton job performance (4); Congressional job performance (2); economy (3); Clinton vs. Republicans in Congress (15); federal budget (2); Vietnam (2); OJ Simpson (8); U.S. Supreme Court (6); favorability of political leaders (7); 1996 election (21); flag burning (1); Bosnia (5); abortion (3); speed limit (1); Whitewater (2); Waco incident (2); Newt Gingrich's book contract (3); television violence (5); Republican primary (2); Democratic primary (2); born again (1).
ABC News/Washington Post Poll: 1996 Election/Medicare
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2014

description: Bill Clinton job performance (4); Congressional job performance (1); Clinton v. Republicans in Congress (14); reducing the federal budget deficit (3); 1996 election (10); third party (6); Ross Perot (2); favorability ratings of political leaders (8); abortion (1); the Catholic Church (3); lifestyles of Catholics (7); Medicare (19); Million Man March (10); 1996 Congressional election (2); Republican primary (1).
Elucidating autophagic dependencies for the treatment of pancreatic cancer
Creators: name: Schechter, Elyse
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is characterized by KRAS- and autophagy-dependent growth. We have previously reported that combined inhibition of the RAS-MAPK pathway, and autophagy, via chloroquine (CQ), is effective at inhibiting the growth of PDAC. While CQ remains the only FDA approved autophagy inhibitor, it lacks in specificity and potency. Thus, we endeavored to determine more efficacious anti-autophagy strategies. We conducted a CRISPR-Cas9 loss-of-function screen in the presence of CQ to identify potential therapeutic targets that when lost would improve the efficacy of CQ and identified multiple targets. We performed a counter screen with siRNA oligos and confirmed that loss of PHF23, PIP4K2A, PIP4K2C, and PIK3C3 increased the sensitivity to CQ compared to the control. Furthermore, we confirmed that loss of PIK3C3 blocked RAS-MAPK pathway inhibitor induced autophagic flux which was further enhanced by CQ treatment. 
Our screen also identified novel, potential anti-autophagy therapeutic targets. To identify these targets, we utilized the undrugged condition of the CRISPR-Cas9 screen. Autophagy-related genes that repress growth when depleted in the absence of CQ represent additional, potential anti-autophagy targets. One such gene, was PIKFYVE. We demonstrated that the PIKfyve inhibitor apilimod potently inhibited autophagic flux. Additionally, we showed that PIKfyve depletion and pharmacological inhibition decreased RAS-MAPK pathway inhibition induced autophagy, decreased cell proliferation, and induced apoptosis to a higher degree than CQ. The targets identified in each of these studies contribute to our understanding of autophagy-targeting therapeutic options for patients with PDAC.
Gallup/Newsweek Poll: College Student Survey
Creators: name: Newsweek
Publisher: name: Roper Center for Public Opinion Research
Year: 2010

description: Food service on campus (9); eating habits of college students (10); college health service (9); privacy of health care information (3); physical fitness of college students (2); drug and alcohol use by college students (10); minorities on campus (16); body weight (4).
Phenolic contents of pasteurised and ozonated camel milk
Creators: name: AJLOUNI Said, RHEE Michelle
Publisher: name: International Society of Antioxidants in Nutrition and Health (ISANH)
Year: 2017

description: Due to the negative impact of heat treatment on milk quality, this study examined ozonation as an alternative pasteurisation technique to maintain quality, acceptable shelf life, and high nutritional value of camel milk.
          Total polyphenol content (TPC) reported as Gallic Acid Equivalent (GAE) in Australian raw camel milk was 12.09±;0.4 mg GAE /100 ml. Ozonation for 5 and 10 min at room temperature significantly (P<0.05) reduced the TPC by 0.66 mg GAE/100 ml and 0.72 GAE mg/100 ml, respectively. Similarly, the TPC in pasteurised milk was significant (p<0.05) decreased by 2.62 mg GAE/100 ml. Similar to the effect of ozonation on TPC, the antioxidant activities in camel milk ozonated for 10 min were significantly (P<0.0) reduced by 0.55 mg TE/100 ml and 4.04 mg TE/100ml using DPPH and ABTS methods, respectively. Results showed also that pasteurisation reduced the antioxidant activities by 3.57 mg TE/100 ml (DPPH method), and 5.40 mg TE/100 ml (ABTS method). HPLC and titration methods demonstrated that vitamin C content in raw camel milk were 3.02±;0.21mg/100 ml and 3.29±;0.03mg/100 ml, respectively. Ozonation for 10 minutes had the greatest effect on the vitamin C content, and caused 76.80% reduction.
description: Archives of ISANH: Vienna Polyphenols 2017
Molecular docking and dynamic simulation to identify potential phytocompound inhibitors for EGFR and HER2 as anti-breast cancer agents
Creators: name: Prabhavathi, H.
name: Dasegowda, K. R.
name: Renukananda, K. H.
name: Karunakar, Prashantha
name: Lingaraju, K.
name: Naika, H. Raja
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Breast cancer is the most prevalent cancer in women worldwide. To treat human breast cancer by inhibiting EGFR and HER2 targets is an important therapeutic option. Phytochemicals are found to have beneficial health effects in treating various diseases. An effort has been made to virtually screen phytochemical inhibitor by molecular docking and dynamic simulation in the current studies. The docking scores analysis resulted in a common hit Panaxadiol ligand with a low dock score for EGFR and HER2 targets. The inhibitory action of the phytocompounds was also validated by comparing it with the reference compounds Erlotinib for EGFR and Neratinib for HER2. Molecular dynamic simulation of EGFR and HER2 lead complexes ensure the ligand's appropriate refinement in the dynamic system. The target and ligand complex interaction motif established a high affinity of lead candidates in a dynamic system similar to molecular docking results. This study reveals that Panaxadiol hit molecule can be developed as a novel multi-target EGFR and HER2 target inhibitor with greater potential and low toxicity. Communicated by Ramaswamy H. Sarma
In-silico screening of bioactive phytopeptides for novel anti-Ageing therapeutics
Creators: name: Salekeen, Rahagir
name: Ahmed, Asif
name: Islam, Md Emdadul
name: Billah, Md Morsaline
name: Rahman, Hafizur
name: Islam, Kazi Mohammed Didarul
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: A metabolic network of energy-sensing molecular pathways drives the biological ageing process. Regulating certain network elements can help decelerate the ageing process and ameliorate ageing associated disorders. Bioactive phytopeptides are a prospective avenue for anti-ageing therapeutics and rejuvenation biotechnology. The present study investigates the potential of therapeutic plant peptides against cellular senescence by targeting three key proteins in the ageing network – target of rapamycin (mTOR), adenosine monophosphate-activated protein kinase (AMPK) and sirtuin 1 (SIRT1). This investigation screened a library of reported bioactive peptides using standard cheminformatic methods including in-silico ADMET, molecular docking, molecular dynamics simulation and molecular mechanics calculation. The retrieved simulation data predict 25 diverse phytopeptides as potential safe and drug-like anti-ageing biologics with half-lives >20 h and bioavailability scores >0.40. The best docked peptide, Cycloleonuripeptide B, exhibited strong binding affinity and stable complex formation with mTOR (-17.5 kCal/mol), SIRT1 (-28.54 kCal/mol) and two active sites in AMPK (-41.8 kCal/mol; −36.0 kCal/mol) during molecular dynamics simulations. The computational study acts as a foundation for future laboratory and clinical research into the potential of repurposing therapeutic phytopeptides against cellular senescence and associated pathophysiology. Communicated by Ramaswamy H. Sarma