cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Symbolic execution of LOTOS specifications.
Creators: name: Ashkar, Pierre.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Computer Science.

description: LOTOS (Language Of Temporal Ordering Specification) is a Formal description Technique (FDT) based on the temporal ordering of observational behaviour. It was developed by ISO (International Organization for Standardization) for the specification of OSI (Open System Interconnection) services and protocols. This thesis presents a method of translating a LOTOS specification written in any given style into either of two simpler forms, known as the Monolithic Style Specification and the Parameterized Tree. A method of applying LOTOS expansion theorems to derive an intermediary form, known as the Behaviour Tree, is described first. A Reduction Algorithm, based on a subset of congruence rules, has been developed to provide a means to eliminate superfluous internal events and branches in the Behaviour Tree prior to conversion to either of the two simpler forms. Methods of transforming the reduced Behaviour Tree to either the Monolithic Style Specification ar Parameterized Tree have been developed. A tool has been developed to demonstrate these concepts. To show the application of this tool, we discuss a method for obtaining test cases from a Monolithic Style Specification. Finally, a method to translate such test cases into TTCN form has been outlined.
The Current Landscape of Prenatal Aneuploidy Screening: Perspectives of Genetic Counselors in the United States
Creators: name: Silver, Jamie
Publisher: name: Brandeis University
Year: 2012
Subjects: genetic counseling
maternal serum screening
non-invasive prenatal diagnosis
aneuploidy screening

description: Currently, there are at least eight different methodologies available to expectant parents who wish to screen prenatally for Down syndrome and other aneuploidies. These techniques, which can incorporate serum, ultrasound and most recently free fetal DNA (ffDNA) technologies, have yielded an evolving menu of options with considerable variability in both sensitivity and specificity. The aim of our study was to assess how genetic counselors are utilizing these various methodologies and to solicit their opinions and recommendations regarding fetal aneuploidy screening programs. We recruited currently practicing prenatal counselors via the NSGC listserv to participate in an anonymous online survey. We received 207 eligible responses to our survey, which consisted of questions regarding specific screening methodologies offered at their institutions, experiences and challenges in counseling patients, and required elements for optimal screening programs.\r Our results indicate that there is considerable variability in the prenatal screening methods used. First trimester screening is the most widely used methodology, offered regularly by 82% of respondents. However, 52% of respondents reported that they regularly offer sequential screening, and 57% offer ffDNA screening either routinely or on a limited case-by-case basis. Many counselors expressed concern about the quality of informed consent when undertaken by non-genetics providers. Of note, almost two-thirds (59%) of respondents indicated that they sometimes, often, or always saw patients for discussion of screening results who did not recall consenting to screening. Factors positively correlated with optimal screening programs were the ability to offer CVS, first trimester screening, ffDNA screening, and pre-screening appointments. The landscape of prenatal aneuploidy screening is likely to change drastically in the coming years, and it is imperative that genetic counselors be involved in the development and implementation of screening programs that effectively integrate both current and future methods while optimizing patient comprehension and autonomy.
title: Ð¡ÑÐ´ÐµÐ±Ð½Ð¾-Ð±Ð°Ð»Ð»Ð¸ÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐºÑÐ¿ÐµÑÑÐ¸Ð·Ð° Ð¸ ÐµÐµ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ Ð² Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ°ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐµÑÑÑÐ¿Ð»ÐµÐ½Ð¸Ð¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ°
titleType: Subtitle
title: Forensic ballistics and its investigation opportunities crimes
Creators: name: ÐÐ°ÑÐ°ÐºÑÐ¸Ð½Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÑÐ´ÐµÐ±Ð½Ð°Ñ ÑÐºÑÐ¿ÐµÑÑÐ¸Ð·Ð°
ÑÑÐ´ÐµÐ±Ð½Ð¾-Ð±Ð°Ð»Ð»Ð¸ÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐºÑÐ¿ÐµÑÑÐ¸Ð·Ð°
Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÑÐºÑÐ¿ÐµÑÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹
Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ
forensic examination
forensic ballistic examination
methods of expert research
software

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¾Ð³Ð½ÐµÑÑÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¾ÑÑÐ¶Ð¸Ñ Ð¸ Ð¿Ð°ÑÑÐ¾Ð½Ð¾Ð², Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±Ñ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¸Ñ Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´Ð°Ð½Ð½ÑÑ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¾Ð² Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¸Ðº Ð¸ ÑÑÐµÐ´ÑÑÐ² Ð² ÑÐµÐ»ÑÑ ÑÐ°ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ ÑÐ°ÑÐºÑÑÑÐ¸Ñ Ð¿ÑÐµÑÑÑÐ¿Ð»ÐµÐ½Ð¸Ð¹, Ð¸Ð·ÑÑÐµÐ½Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½ÑÐµ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ, ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²ÑÑÑÐ¸Ðµ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ Ð¾Ð±ÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÑÐºÑÐ¿ÐµÑÑÐ°. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐµ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ ÑÑÐ´ÐµÐ±Ð½Ð¾-Ð±Ð°Ð»Ð»Ð¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐºÑÐ¿ÐµÑÑÐ¸Ð·Ñ Ð½Ð° ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¼ ÑÑÐ°Ð¿Ðµ.
description: In this work, the signs of the use of firearms and cartridges are considered, as well as ways to detect and study these signs using developed techniques and tools for the investigation and disclosure of crimes, software packages that enhance the objectivity and effectiveness of the experts activities are studied. As a result of the research, actual problems of forensic ballistics examination at the present stage have been identified.
BOSHLANG'ICH TA'LIMDA TARBIYA DARSLARINI O'TISHDA INNOVATSIYON YONDASHUNVNING AHAMIYATI
Creators: name: Joʻrayeva, Margʻuba
name: Bovanova, Umida
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada boshlang‘ich sinf o‘quvchilarining o‘qiv faoliyatida, tarbiya darslarini o‘qitishda innovatsion yondashuvlarning ahamiyati ko‘rib chiqiladi. Zamonaviy ta’lim jarayonida o‘quvchilar faqat bilim olish bilan cheklanmay, balki shaxs sifatida rivojlanishlari ham zarur. Innovatsion yondashuvlar, interaktiv o‘yinlar, giyomifikatsiya, loyiha asosida o‘qitish va raqamli texnologiyalarni qo‘llash, o‘quvchilarning qiziqishini oshirish va darslarda faol ishtirok etishlarini ta’minlashga yordam beradi. Innovatsion metodlar orqali tarbiya darslarida o‘quvchilarning ijtimoiy ko‘nikmalarini rivojlantirish, jamoaviy ishga tayyorlash va muammolarni hal qilish qobiliyatini oshirish mumkin. Bunday yondashuvlar nafaqat bilimlarni mustahkamlash, balki o‘z-o‘zini shaxsiy rivojlanishiga ham xizmat qiladi.
A GLIAL CIRCADIAN TRANSCRIPTOME AND METHODOLOGICAL ANALYSIS OF SPARSE RHYTHMIC DETECTION
Creators: name: Rashkover, Teddy
Publisher: name: Brandeis University
Year: 2026
Subjects: Circadian transcriptomcis
Glial transcriptome
Single-cell transcriptomics

description: Following the observation of core circadian gene per expression in both Drosophila clock neurons and glial tissue in 1992, an ensuing vein of research has uncovered networks of circadian protein regulation and associated function.1 One instance found a structural and functional divergence between circadian architectures of glial cells and clock neurons per the glial expression of the cycling protein (and transcript of) Ebony.2 The extent of architectural divergence remains understudied, both between clock neurons and glia as well as between glial cell-types; absent is a comprehensive and corroborated circadian analysis of the glial transcriptome. In this work, I document a 2h, 12-timepoint single-cell RNA-seq transcriptome of adult Drosophila glia, I detail the cell-type specificity of circadian gene regulation, and I suggest corresponding regulatory mechanisms and functions. Notably, I evidence the comparative rhythmic prominence of ensheathing glia, a cell type relatively understudied in a circadian context. In addition, I cross-analyze results of four pertinent sequencing experiments and address two methodological flaws relevant to their limited reproducibility.
Language and the definition of art: Analytic and continental discussion of the nature of art.
Creators: name: Lech-Piwowarczyk, Ewa.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Fine Arts.

description: Art has a definite place in our culture and it plays a significant role there. Yet all the continuing efforts in analytic aesthetics to define art have failed, leading to an impasse. So, we still do not know how to define art. In order to overcome the impasse I argue that a change of philosophical perspective is necessary and I suggest a confrontation between Continental and analytic perspectives on defining art. In Part One I deal with analytic aesthetics. I single out Danto's theory of art as the paradigmatic analytic theory of art. I call attention to the fact that Danto defines art by means of language, a theory of art which is a discourse on the language of art. I show the impact of Danto's theory on the rest of analytic aesthetics. First, I present Dickie's theory of art of and show how he draws from Danto but departs from him later on. Then, I present Tilghman's critique of Danto, and I stress the point that in Tilghman's view the problem with Danto's theory is linguistic in nature. I identify Danto's understanding of language as the source of the problems recent analytic aesthetics has with the definition of art. In this way I locate the current impasse in analytic aesthetics and I claim that the underlying analytic understanding of language is too narrow in order to define art. I show the evolution of Danto's views and I discuss his attempt to enlarge his understanding of language with history. In Part Two I try to suggest a way out of the impasse. I shift the perspective and turn to phenomenology and Ingarden's theory of art. I call attention to the role of language in his philosophy and present his approach as quasi-analytical. Specifically, I interpret Ingarden as the continuator of Twardowski and not of Husserl in his understanding of language. I point to the fact that Ingarden's non-phenomenological view of language is a view that allows of seeing language not only as a container of ideas but also their shaper. I show that Ingarden attributes to language an attentional mode of being, and that he treats it as a means of communication. He exposes its cultural nature and enlarges its understanding with the notion of society. I claim that such a broader understanding of language may help analytic aesthetics overcome the present impasse. In Conclusion, I argue that supplementing the notion of language with the notion of history, as Danto does, or society, as Ingarden does, provides a fuller understanding of language, and consequently of art. Hence, it makes possible the overcoming of the impasse in analytic aesthetics. At the same time, however, I show that the very project of defining art has to be relativized in terms of understanding and responding to the significance of art.
Sage and the city: A case study of identity at an urban Aboriginal organization
Creators: name: Reno, Dorothy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Sociology, Social Structure and Development.
subject: Native American Studies.

description: In the past few decades, Aboriginals in Canada have undergone a steep urban transition. The challenges associated with the city, such as racism, poverty, feelings of dislocation, coping and thriving within the broader Canadian society, and negotiating identity, are all issues which led to the creation of urban cultural centres and organizations. Within the context of these organizations, the communities that are formed are multicultural in the sense of bringing together all Aboriginal peoples from a variety of First Nations, Metis and Inuit backgrounds. On one hand, Aboriginal cultural centres are faced with the challenge of respectfully acknowledging the diverse cultures of Aboriginal peoples, while on the other, identifying, and celebrating the common cultural values shared by all Aboriginals. Cultural centres have also stepped up to offer support for Aboriginal people(s) in the ongoing negotiation with modernity and the healing through the process of cultural reclamation. This study, which is exploratory in nature, examines identity at an urban Aboriginal cultural centre, from both individual, and community perspectives. In true postmodern fashion, this work melts away disciplinary boundaries by taking on theoretical approaches from sociology, anthropology, and political philosophy.
title: ÐÐ¾Ð½ÑÑÐ¸ÑÑÑÐ¸Ð¾Ð½Ð½Ð¾Ðµ ÑÑÐ´Ð¾Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾ Ð² Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Constitutional legal proceeding of Russia Federation
Creators: name: ÐÐ°ÐºÐ°Ð´Ð¶Ð°Ð½Ð¾Ð², Ð¡ÐµÑÐ´Ð°Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐºÐ¾Ð½ÑÑÐ¸ÑÑÑÐ¸Ð¾Ð½Ð½Ð¾Ðµ ÑÑÐ´Ð¾Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾
ÐÐ¾Ð½ÑÑÐ¸ÑÑÑÐ¸Ð¾Ð½Ð½ÑÐ¹ ÑÑÐ´
constitutional legal proceeding of Russia Federation

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð³ÐµÐ½ÐµÐ·Ð¸ÑÑ Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² ÐÐ¾Ð½ÑÑÐ¸ÑÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÑÐ´Ð°, Ð½Ð°ÑÐ¸Ð½Ð°Ñ Ð¾Ñ ÑÐ²Ð¾ÐµÐ³Ð¾ Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð·Ð°ÐºÐ°Ð½ÑÐ¸Ð²Ð°Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ð¼Ð¸ Ð½Ð° ÑÐµÐ³Ð¾Ð´Ð½ÑÑÐ½Ð¸Ð¹ Ð´ÐµÐ½Ñ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐ¼Ð¸ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð°Ð¼Ð¸. Ð ÑÐ¾Ð´Ðµ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð°ÐºÑÑ, ÑÐµÐ³ÑÐ»Ð¸ÑÑÑÑÐ¸Ðµ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² ÐÐ¾Ð½ÑÑÐ¸ÑÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¡ÑÐ´Ð° Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ð¸ Ð½Ð° ÐºÐ°Ð¶Ð´Ð¾Ð¼ ÑÑÐ°Ð¿Ðµ ÐµÐ³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ, Ð²ÑÑÐ²Ð»ÐµÐ½ ÑÑÐ´ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÑ Ð½Ð° ÑÐµÐ³Ð¾Ð´Ð½ÑÑÐ½Ð¸Ð¹ Ð´ÐµÐ½Ñ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð½Ð°Ð¹Ð´ÐµÐ½Ð½ÑÑ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼ Ð±ÑÐ»Ð¸ ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ð½ÑÑ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼.
description: The work is devoted to the genesis and development of the bodies of Constitutional Court, starting from its foundation, ending with the current problems that exist today. In the course of this work, the acts regulating the activities of bodies of the Constitutional Court of the Russian Federation at each stage of its development were analyzed, and several current problems were identified. In the course of the work and analysis of the problems found, proposals were formulated to solve the identified problems.
Infinitival subordination in Spanish: A study of control, raising and ECM constructions in bilingual and non-native acquisition
Creators: name: Perez Tattam, Rocio Simone
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Language, Linguistics.
subject: Language, Modern.

description: This dissertation investigates the acquisition of infinitival clauses by child bilingual (L1 English/L1 Spanish) and adult non-native (L1 English/L2 Spanish) learners in Control, Raising and ECM configurations as shown in examples (i)-(iiii). (i) Juani quiere [PROi ver a Maria] John wants [PROi to see to Mary]; (ii) Juan obligo a Maria i a [PROi tomar una decision] Juan forced Maryi [PROi to decide]; (iii) Juani parece [ti estar cansado] John seems [ti to be tired]; (iv) Juan vio a Maria [regar las plantas] (John saw Mary watering the plants) John believes Mary [to be a friend]. The first part of this dissertation deals with the development of infinitival clauses in natural production data from bilingual children compared to monolingual (L1 English and L1 Spanish) children [ages 2;03-5;01], and the interaction of the relevant formal properties in bilingual grammars where Spanish and English do not match. The second part of this dissertation also deals with interaction regarding their formal and structural properties where L1 and L2 grammars do not match. I study the acceptance and comprehension of infinitival clauses in experimental data from adults learning Spanish in an institutional setting. I statistically compare them to a control group of adult native speakers in order to determine the effect of the L1. I also divide the experimental group into two levels, intermediate and advanced, in order to study the effect of the level of language proficiency. The main goal of this dissertation is to provide more insights on similarities and differences between the bilingual and non-native acquisition processes, particularly regarding transfer of formal properties associated with functional categories and projections related to Control, Raising and ECM constructions (i.e., Tense and the Complementizer system). Ultimately, this dissertation may contribute to a better understanding of the nature of bilingual and L2 grammars, and to the discussion regarding the similarities and differences between L1 and L2 acquisition by looking at factors that can be studied when more than one grammar is available.
title: ÐÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÐºÑÑÐ¿Ð½Ð¾Ð³Ð°Ð±Ð°ÑÐ¸ÑÐ½ÑÑ Ð¸Ð·Ð´ÐµÐ»Ð¸Ð¹ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐµ 3d-Ð¿ÐµÑÐ°ÑÐ¸ Ð¼ÐµÑÐ°Ð»Ð»Ð°Ð¼Ð¸. Ð¡Ð²Ð¾Ð¹ÑÑÐ²Ð° ÐºÐ¾Ð½ÐµÑÐ½Ð¾Ð³Ð¾ Ð¸Ð·Ð´ÐµÐ»Ð¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Predicting the behavior of large-sized products in the process of 3D metal printing. Properties of the final product
Creators: name: ÐÐ°ÑÑÑÐ°ÐºÐ¾Ð², ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: 3D-Ð¿ÐµÑÐ°ÑÑ Ð¼ÐµÑÐ°Ð»Ð»Ð°Ð¼Ð¸
Ð¼ÐµÑÐ¾Ð´ ÑÐµÐ»ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð»Ð°Ð·ÐµÑÐ½Ð¾Ð³Ð¾ Ð¿Ð»Ð°Ð²Ð»ÐµÐ½Ð¸Ñ
Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ 3D-Ð¿ÐµÑÐ°ÑÐ¸
3D printing with metals
selective laser melting method
3D printing prediction

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ð¾ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÐºÑÑÐ¿Ð½Ð¾Ð³Ð°Ð±Ð°ÑÐ¸ÑÐ½ÑÑ Ð¸Ð·Ð´ÐµÐ»Ð¸Ð¹ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐµ 3D-Ð¿ÐµÑÐ°ÑÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð¾ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ Ð´Ð»Ñ Ð·Ð°Ð´Ð°ÑÐ¸ Ð¾ Ð½Ð°Ð³ÑÐµÐ²Ðµ ÑÐ¾Ð½ÐºÐ¾Ð³Ð¾ Ð¸ ÑÐ»Ð¾Ñ Ð¸ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð½Ð° ÐºÐ¾Ð½ÐºÑÐµÑÐ½Ð¾Ð¼ Ð¿ÑÐ¸Ð¼ÐµÑÐµ, ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐ¼Ð¸ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸.
description: This paper describes the behavior of large-sized products during the 3D printing process. An analytical solution for the problem of heating a thin layer is obtained and a comparison of the analytical and numerical solutions is given. A comparative analysis was carried out using a specific example, comparing the numerical solution with experimental data.
An immunochemical analysis of human apolipoprotein B-100 structure-function relationships.
Creators: name: Wang, Xingyu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Molecular.

description: Low density lipoproteins (LDL), the major cholesterol carriers in human plasma contain a single copy of apolipoprotein B-100 (apoB-100), a 4536 residue, water-insoluble polypeptide as their exclusive protein component. ApoB-100-containing lipoproteins (LpB) are secreted from the liver as large triglyceride-rich lipoproteins and are converted in the circulation to smaller cholesteryl ester-rich LDL. As a ligand for the cell surface LDL receptor, apoB-100 has an important role in cholesterol metabolism and elevated apoB-100 levels increase the risk of atherosclerosis. Genetic polymorphism, oxidative modification, non-enzymatic glycation and the lipid environment of apoB-100 can affect its ability to mediate binding to the LDL receptor. In my Ph.D. program, I have produced and employed a panel of anti-apoB-100 monoclonal antibodies (mAbs) to study apoB structure and function. To this end, I developed and evaluated 3 novel immunization strategies to generate apoB-100 isoform-specific mAbs. Immunization of human apoB-100 transgenic mice proved to be an effective method for production of anti-apoB-100 mAbs having unusual specificities. This strategy could also be applied to other antigens. Several mAbs produced by this protocol are shown to be useful probes of apoB-100 conformation. I have characterized the binding specificities of a large panel of anti-apoB-100 mAbs and have analyzed the expression of their corresponding epitopes on LpB as a function of LpB intravascular metabolism. I show that the apoB-100 carboxy-terminus undergoes a major conformational change as large LDL are converted to smaller particles, a conformational change that could allow the particle to become competent to mediate binding to the LDL receptor. Finally, I demonstrate that, when LDL undergoes non-enzymatic glycation, at least 6 sites in apoB-100 are modified, including 2 that flank the apoB LDL receptor-binding site. As the LDL receptor-binding site itself is not modified, the loss of binding activity may be secondary to a change in apoB conformation.
NM-SRNs: 22nd March 2025 - AGI Achieved
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2025

description: Abstract

The pursuit of Artificial General Intelligence (AGI) has been a central goal of computer science since its inception. While recent advances in deep learning, particularly with Large Language Models (LLMs), have showcased impressive capabilities, they remain fundamentally limited by their reliance on statistical correlations, vast datasets, and opaque architectures. This paper announces the achievement of AGI on March 22nd, 2025, through the Neural-Matrix Synaptic Resonance Network (NM-SRN) architecture. NM-SRNs, designed from the outset for general intelligence, represent a paradigm shift, combining the strengths of symbolic and connectionist AI. The Generative Simple Dictionary Transformer (GSDT), a functional implementation of core NM-SRN principles, verifies the viability of this approach, demonstrating robust Natural Language Processing (NLP) capabilities without backpropagation or extensive pre-training. Key breakthroughs include Turing completeness by design, a novel resonance-based computation mechanism (details withheld for proprietary reasons), inherent explainability (XAI), and a modular architecture that promotes scalability and adaptability. This paper presents the NM-SRN framework, highlights the GSDT's significance, and outlines the transformative potential of this AGI achievement across diverse fields.

contact: info@bioneuralai.com
Focus on Nursing, January 2022
Creators: name: Washington State University College Of Nursing
Publisher: name: Washington State University
Year: 2022
Subjects: subject: Newsletters
subject: Nursing
subject: FOS: Health sciences

description: News items include: Diverse group of nursing students bond during pandemic; WSU nursing student selected for
description: mountain rescue team at Beijing Olympics; WSU College of Nursing alumni tell us what they’re doing and how they’re doing; Faculty accomplishments, honors and awards, and research news; Your support helps students succeed; Research on professional identity in nursing, massage for pain management, workplace adjustments to curb burnout rates for nurses and more; Student awards, recognition, and community outreach.
Serve and Tell: An Investigation of Volunteering in a College Context
Creators: name: Parrack, Rynn
Publisher: name: Brandeis University
Year: 2023
Subjects: Volunteers

description: Why do college students volunteer in college? This research investigates who typically volunteers, for how long they volunteer, and why they volunteer in college. Motivations for volunteering in college are complicated by a desire to help the community and to achieve career or other personal goals. Drawing on survey and interview data, I analyzed the motivations of college volunteers through thematic analysis of survey and interview responses. The survey responses show that the majority of volunteers choose to volunteer due to their previous experiences volunteering and their interest in working with a specific population such as children, older adults, and the houseless. The interviews demonstrate that motivation type moderates the level of involvement from volunteers. These findings can be applied to the “leisure constraints model” of volunteering in college, where volunteers choose to volunteer based on their schedules and their need for personal satisfaction - whether they find satisfaction in the act of volunteering or the social benefits of volunteering.
Strategic marketing plan to achieving organizational performance: a case study of Nigerian brewery.
Creators: name: Philip, Lydia
Publisher: name: figshare
Year: 2020
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business
subject: 159999 Commerce, Management, Tourism and Services not elsewhere classified
subject: 150301 Business Information Management (incl. Records, Knowledge and Information Management, and Intelligence)
subject: 150302 Business Information Systems
subject: 150299 Banking, Finance and Investment not elsewhere classified
subject: 150304 Entrepreneurship
subject: 150201 Finance
subject: 150305 Human Resources Management
subject: 150308 International Business
subject: 150503 Marketing Management (incl. Strategy and Customer Relations)

description: The ideal outcome of this thesis is to design strategic marking plan to help the
Nigerian
Breweries become a successfulManufactory and strengthen the brand
image.Quantitative and a qualitative research methods were used in this thesis
research. An internal analysis, PESTEL analysis and SWOT analysis are also presented
in this thesis.
NM-SRNs: 22nd March 2025 - AGI Achieved
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Artificial intelligence
subject: Artificial Intelligence
subject: Machine learning
subject: Machine Learning
subject: Machine Learning/standards

description: Abstract

The pursuit of Artificial General Intelligence (AGI) has been a central goal of computer science since its inception. While recent advances in deep learning, particularly with Large Language Models (LLMs), have showcased impressive capabilities, they remain fundamentally limited by their reliance on statistical correlations, vast datasets, and opaque architectures. This paper announces the achievement of AGI on March 22nd, 2025, through the Neural-Matrix Synaptic Resonance Network (NM-SRN) architecture. NM-SRNs, designed from the outset for general intelligence, represent a paradigm shift, combining the strengths of symbolic and connectionist AI. The Generative Simple Dictionary Transformer (GSDT), a functional implementation of core NM-SRN principles, verifies the viability of this approach, demonstrating robust Natural Language Processing (NLP) capabilities without backpropagation or extensive pre-training. Key breakthroughs include Turing completeness by design, a novel resonance-based computation mechanism (details withheld for proprietary reasons), inherent explainability (XAI), and a modular architecture that promotes scalability and adaptability. This paper presents the NM-SRN framework, highlights the GSDT's significance, and outlines the transformative potential of this AGI achievement across diverse fields.

contact: info@bioneuralai.com
Emerging use of air eDNA and its application to forensic investigations – A review
Creators: name: Goray, M
name: Taylor, D
name: Bibbo, E
name: Fantinato, C
name: Fonneløp, AE
name: Gill, P
name: van Oorschot, Roland
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 3401
subject: Analytical chemistry
classificationCode: 3105
subject: Genetics

description: Biological material is routinely collected at crime scenes and from exhibits and is a key type of evidence during criminal investigations. Improvements in DNA technologies allow collection and profiling of trace samples, comprised of few cells, significantly expanding the types of exhibits targeted for DNA analysis to include touched surfaces. However, success rates from trace and touch DNA samples tend to be poorer compared to other biological materials such as blood. Simultaneously, there have been recent advances in the utility of environmental DNA collection (eDNA) in identification and tracking of different biological organisms and species from bacteria to naked mole rats in different environments, including, soil, ice, snow, air and aquatic. This paper examines the emerging methods and research into eDNA collection, with a special emphasis on the potential forensic applications of human DNA collection from air including challenges and further studies required to progress implementation.
NM-SRNs: 22nd March 2025 - AGI Achieved
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Artificial intelligence
subject: Artificial Intelligence
subject: Machine learning
subject: Machine Learning
subject: Machine Learning/standards

description: Abstract

The pursuit of Artificial General Intelligence (AGI) has been a central goal of computer science since its inception. While recent advances in deep learning, particularly with Large Language Models (LLMs), have showcased impressive capabilities, they remain fundamentally limited by their reliance on statistical correlations, vast datasets, and opaque architectures. This paper announces the achievement of AGI on March 22nd, 2025, through the Neural-Matrix Synaptic Resonance Network (NM-SRN) architecture. NM-SRNs, designed from the outset for general intelligence, represent a paradigm shift, combining the strengths of symbolic and connectionist AI. The Generative Simple Dictionary Transformer (GSDT), a functional implementation of core NM-SRN principles, verifies the viability of this approach, demonstrating robust Natural Language Processing (NLP) capabilities without backpropagation or extensive pre-training. Key breakthroughs include Turing completeness by design, a novel resonance-based computation mechanism (details withheld for proprietary reasons), inherent explainability (XAI), and a modular architecture that promotes scalability and adaptability. This paper presents the NM-SRN framework, highlights the GSDT's significance, and outlines the transformative potential of this AGI achievement across diverse fields.

contact: info@bioneuralai.com
description: NEW Updated MIT Licence added and project weblinks and github.
title: The Relationship Between Maternal Education and Anatomical Connectivity in U.S. and Bangladeshi Children
title: A Cross-Cultural Study
titleType: Subtitle
Creators: name: Mougiou, Angela
Publisher: name: Brandeis University
Year: 2021
Subjects: White Matter
Cross-cultural
FA
ILF
IFOF
SLF
AF
Low-resource Setting
Bangladesh
Children & Youth
Magnetic Resonance Imaging
United States

description: Previous research conducted in high-resource countries suggest correlations between SES factors, such as maternal education, and the structure of white matter and therefore brain connectivity (Ozernov-Palchik et al. 2018; Gullick et al. 2016). However, whether this relationship also holds in other low-resource settings remains unclear. This paper examines if the relationship between maternal education and anatomical connectivity on the brain of U.S. children can also be observed in Bangladeshi children. A similar relationship was expected to be observed in the both groups. To test this hypothesis, diffusion MRI data from two different groups, composed of 55 U.S. and 88 Bangladeshi children, respectively, were analyzed. Based on the results of previous research that examined the relationship between parental education and brain development (Ozernov-Palchik et al. 2018; Gullick et al. 2016), tractography was performed for the following four white matter tracts: the inferior longitudinal fasciculus (ILF), the superior longitudinal fasciculus (SLF), the inferior fronto-occipital fasciculus (IFOF), and the arcuate fasciculus (AF). A trending positive correlation was observed in the right ILF in the U.S. children and a significant negative correlation was observed in the right SLF in the Bangladeshi group of children. These results suggest potential differences in the interactive relationship between maternal education and white matter tract development in children from high-resource settings compared to children from low-resource settings, which should be further examined in future research studies. Further examining the potential cross-cultural presence of the correlation between maternal education and anatomical connectivity would help highlight the importance of women receiving higher levels of education and encourage it in developing countries such as Bangladesh.
The survival of Native territorial sovereignty in Canadian land claims law: Acknowledging and historical fact.
Creators: name: Youssef, Michel.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: History, Canadian.

description: The thesis of this dissertation is that the sovereignty of Natives over their ancestral lands not transferred by treaty or conquest was always recognized by the various colonial Powers who successively claimed Canada. The focus of the paper is legal. The aim is to prove the maintainability at law, and specifically at Canadian law, of Native territorial sovereignty. The paper does not attempt to describe the qualities this legal sovereignty possesses. To prove the thesis, the study takes a primarily historical perspective in determining what was the law of the various Powers at the relevant time as concerns the status of indigenous populations and their territories in newly discovered lands. The dissertation begins in chapter two, by examining international law. Chapters three, four and five then look at the practices, respectively, of Spain and Portugal, of France and of England as the principal Powers involved in the colonial history of Canada. In chapter six, the study turns to the judicial arena and examines Canadian caselaw, and its American influences. It also engages in a comparative review of the caselaw in Australia and New Zealand. Finally, having established that Native sovereignty is at least theoretically part of the law Canada inherited and that the issue has not been judicially foreclosed, chapter seven examines the treaty and comprehensive land claims agreement processes in Canada. To show that vast parts of the country which were occupied by Indians at the time of European contact, remain so today, and are not yet under treaty. These areas constitute territories over which Canadian sovereignty has wrongly been assumed which potentially could be lost to Canada if not secured by treaty. (Abstract shortened by UMI.)
Catalytic Asymmetric Direct Aldol Reaction of alpha-Alkyl Azlactones and Aliphatic Aldehydes for the Synthesis of Protected beta-Hydroxy-alpha-Amino Acids
Creators: name: Zheng, Yang
Publisher: name: Brandeis University
Year: 2015
Subjects: Cinchona Alkaloid
beta-Hydroxy-alpha-Amino Acid
Asymmetric Catalysis
Direct Aldol Reaction
alpha-Alkyl Azlactone
mycestericin natural products
immunosuppressant
sphingosine analogs

description: Optically active beta-hydroxy-alpha-amino acids are an important class of amino acids as they exist as structural components of many biologically active natural products such as vancomycin, katanosins, cyclosporin, ustiloxins, lactacystin, myriocin, mycestericins, threonine and sphingosine. Furthermore, these beta-hydroxy-alpha-amino acids are also useful chiral building blocks in organic synthesis, as illustrated by their transformations into beta-lactams, beta-halo-alpha-amino acids, and aziridines. The catalytic asymmetric synthesis of beta-hydroxy-alpha-amino acids and their derivatives has been realized by different catalytic methods. For the catalytic asymmetric synthesis of beta-hydroxy-alpha-amino acids and their derivatives with tertiary beta-centers and quaternary alpha-centers, there were two unsolved problems: 1) high diastereoselectivity when both tertiary beta-center and quaternary alpha-center have alkyl substituents; 2) high anti-diastereoselectivity. These problems have been solved by our new catalytic asymmetric direct aldol reaction of alpha-alkyl azlactones and aliphatic aldehydes. To the best of our knowledge, this is the first time that a direct aldol reaction of the azlactone and the aldehyde is reported. No similar direct aldol reactions with nucleophilic amino acid equivalents other than azlactones are available for making aldol products with free beta-hydroxy groups. This is also the first time that the protected beta-hydroxy-alpha-amino acid bearing alkyl substituents at both tertiary beta-center and quaternary alpha-center is synthesized by a catalytic asymmetric approach with high enantioselectivity and diastereoselectivity. The high anti-diastereoselectivity obtained for the synthesis of protected beta-hydroxy-alpha-amino acids having tertiary beta-centers and quaternary alpha-centers is unprecedented for a catalytic asymmetric approach with a general scope. This new method has enabled us to achieve an unprecedented scope in the synthesis of protected beta-hydroxy-alpha-amino acids. This promising method could be applied to the synthesis of highly immunosuppressant mycestericin natural products and sphingosine analogs in search of new drug leads.
Identification of potential inhibitors for HCV NS5b of genotype 4a by combining dynamic simulation, protein–ligand interaction fingerprint, 3D pharmacophore, docking and 3D QSAR
Creators: name: El-Hassab, Mahmoud Abd El-Monem
name: El-Bastawissy, Eman Esmat
name: El-Moselhy, Tarek Fathy
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: HCV NS5B polymerase has been one of the most attractive targets for developing new drugs for HCV infection and many drugs were successfully developed, but all of them were designed for targeting Hepatitis C Virus genotype 1 (HCV GT1). Hepatitis C virus genotype 4a (HCV GT4a) dominant in Egypt has paid less attention. Here, we describe our protocol of virtual screening in identification of novel potential potent inhibitors for HCV NS5B polymerase of GT4a using homology modeling, protein–ligand interaction fingerprint (PLIF), docking, pharmacophore, and 3D CoMFA quantitative structure activity relationship (QSAR). Firstly, a high-quality 3D model of HCV NS5B polymerase of GT4a was constructed using crystal structure of HCV NS5B polymerase of GT1 (PDB ID: 3hkw) as a template. Then, both the model and the template were simulated to compare conformational stability. PLIF was generated using five crystal structures of HCV NS5B (PDB ID: 4mia, 4mib, 4mk9, 4mka, and 4mkb), which revealed the most important residues and their interactions with the co-crystalized ligands. After that, a 3D pharmacophore model was developed from the generated PLIF data and then used as a screening filter for 17000328 drug-like zinc database compounds. 900 compounds passed the pharmacophore filter and entered the docking-based virtual screening stage. Finally, a 3D CoMFA QSAR was developed using 42 compounds as a training and 19 compounds as a test set. The 3D CoMFA QSAR was used to design and screen some potential inhibitors, these compounds were further evaluated by the docking stage. The highest ranked five hits from docking result (compounds (p1–p4) and compound q1) were selected for further analysis. Communicated by Ramaswamy H. Sarma
Connecting the Next Generation: A Case Study in Shabbat
Creators: name: Taksar, Evan
Publisher: name: Brandeis University
Year: 2015
Subjects: Shabbat
Hornstein Jewish Professional Leadership
Boston
Jewish Communal Leadership

description: This thesis is the culmination of an eight-month investigation into Jewish young adult\r engagement in the Boston Jewish community. I looked at the history of American Jewish\r identity, and the relevant literature specific to Jewish identity and Jewish Millennials. I identified\r four different organizations in Boston currently providing Shabbat engagement opportunities to\r this demographic. I spent time attending Shabbat programs, as well as speaking with program\r professionals and program participants. This is a qualitative study; through my many\r conversations I hope to identify what makes a Friday evening Shabbat program successful in\r reaching and engaging the Millennial generation. In this thesis I will share the outcome of my\r interviews, and provide recommendations for an organization looking to build a strong young\r adult Shabbat engagement program. Based on my research, there are several important factors\r that contribute to a successful engagement program, including special attention to program\r space, clearly defined program objectives and outcome measurements, and a community organizing\r approach to engagement and empowerment.
Regulating learning and teaching: A case study of Ontario elementary teachers in an era of standards and testing
Creators: name: Chouinard, Jill-Anne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Education, Tests and Measurements.
subject: Education, Elementary.

description: The current trend in Ontario toward greater educational accountability through standardized curriculum and testing appears to be based largely on the hope that compliance with external standards will lead to a more transparent, uniform, and predictable educational system. Through a focus group and individual interviews, this case study explores the experiences and perceptions of three elementary school teachers from one school who are required to implement the Ontario curriculum, as well as to provide annually administered standardized tests to their students in reading, writing and mathematics. The research conducted suggests how specific aspects of the tension between teachers' localized perceptions of classroom life and provincial curricular requirements and Education Quality and Accountability Office (EQAO) testing are redefining the educational realities experienced by students and teachers in one contemporary Ontario school and its classrooms.
Mitogen activated protein kinase-1 and cell division control protein-42 are putative targets for the binding of novel natural lead molecules: a therapeutic intervention against Candida albicans
Creators: name: Dharshini Gopal
name: Muddebihalkar, Aditi G
name: Sinosh Skariyachan
name: Akshay Uttarkar C
name: Prinith Kaveramma
name: Ulluvangada Praveen
name: Roshini Ravi Shankar
name: Tejaswini Venkatesan
name: Niranjan, Vidya
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Candida albicans, fungal yeast causes several lethal infections in immune-suppressed patients and recently emerged as drug-resistant pathogens worldwide. The present study aimed to screen putative drug targets of Candia albicans and to study the binding potential of novel natural lead compounds towards these targets by computational virtual screening and molecular dynamic (MD) simulation. Through extensive analysis of mitogen-activated protein kinase (MAPK) signalling pathways, mitogen-activated protein kinase-1 (HOG1) and cell division control protein-42 (CDC42) genes were prioritized as putative targets based on their virulent functions. The three-dimensional structures of these genes, not available in their native forms, were computationally modeled and validated. 76 lead molecules from various natural sources were screened and their drug likeliness and pharmacokinetic features were predicted. Among these ligands, two lead molecules that demonstrated ideal drug-likeliness and pharmacokinetic features were docked against HOG1 and CDC42 and their binding potential was compared with the binding of conventional drug Fluconazole with their usual target. The prediction was computationally validated by MD simulation. The current study revealed that Cudraxanthone-S present in Cudrania cochinchinensis and Scutifoliamide-B present in Piper scutifolium exhibited ideal drug likeliness, pharmacokinetics and binding potential to the prioritized targets in comparison with the binding of Fluconazole and their usual target. MD simulation showed that CDC42-Cudraxanthone-S and HOG1-Scutifoliamide-B complexes were exhibited stability throughout MD simulation. Thus, the study provides significant insight into employing HOG1 and CDC42 of MAPK as putative drug targets of C. albicans and Cudraxanthone-S and Scutifoliamide-B as potential inhibitors for drug discovery. Communicated by Ramaswamy H. Sarma
Static Search: An Archivable and Sustainable Search Engine for the Digital Humanities
Creators: name: Holmes, Martin
name: Takeda, Joseph
Publisher: name: Zenodo
Year: 2020
Subjects: static websites
archivability
search engines

description: Abstract:The end-goal of the Endings Project—a collaboration between project leaders, programmers, and librarians to address long term sustainability of digital humanities resources—is to have completely static sites: websites composed of only HTML, CSS, and Javascript that have no reliance on server-side processing. Now in the last phase of the grant cycle, the Endings Project successfully converted its major projects—like The Map of Early Modern London, The Robert Graves Diaries, and other HCMC-hosted projects—into static sites, but one final problem remained: search. Most search engines (like Solr) require the use of a server to index content and while Javascript search engines, such as Lunr, do exist, they cannot feasibly handle the vast amounts of data that comprise the standard digital edition.

 This presentation outlines the creation of Static Search: an open-access codebase for creating a completely client-side search engine for static websites. Built using XSLT3, Saxon, and Ant, Static Search creates a JSON file for every distinct stem in a document collection and harvests metadata from each document containing that stem, providing a rapid mechanism for querying a document collection. In its current version, Static Search provides boolean searches (CAN CONTAIN, CANNOT CONTAIN, MUST CONTAIN) as well as exact phrase searching alongside faceted search filters based on document metadata. While currently implemented only for modern English, we are developing methods for querying early modern English as well as early modern and contemporary French as well as adding mechanisms for wildcard searches. Our presentation thus demonstrates both the feasibility of creating a static site with robust search capabilities and the advantages of Static Search for complex digital humanities projects.