cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lasiodiplodia theobromae disease symptom development in young avocado (Persea americana L.) plants depends on the inoculation method
Creators: name: Rodríguez-Gálvez, Edgar R.
name: Haro-Diaz, Cesar
name: Maza-Aguirre, Samir
name: Canahuire-Castillo, Fátima
name: Sullón-Saucedo, Julio
name: Deising, Holger
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 580

description: Lasiodiplodia theobromae is a pathogenic fungus of more than 500 plant species, including avocado (Persea americana Mill.). The global production volume of avocado exceeded 911,000 metric tons in 2023. Although detailed quantitative surveys of yield losses caused by L. theobromae are not available for most avocado-producing regions, estimates indicate that this pathogen is associated with stem-end rot disease in 30-35% of plots located in the Department of Antioquia in Colombia (Ramírez-Gil et al. Heliyon 7: e05905, 2021), suggesting an enormous economic impact. As yield losses strongly depend on the virulence of isolates, a reliable method for determining their aggressiveness is indispensable for initiating disease control measures. In this study, we compared progression of external and internal necrosis caused by the aggressive L. theobromae isolate LA-VLCA3 inoculated into wounded middle parts of the stem and onto excised apices. Irrespective of the inoculation method, internal progression of necrosis preceded that of external necrosis. Spreading of external and internal necrosis was significantly more severe in plants inoculated at the apex than in mid-stem inoculated plants. We conclude that apex inoculation causes stronger symptoms and is therefore better suited to compare virulence of isolates than mid-stem inoculation.
title:  La ricerca sui counselor REICO. Esplorare un campo nuovo con l’aiuto del diamante culturale
Creators: name: Casavecchia, Andrea
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2024

description: Il capitolo illustra l’impostazione teorica e la metodologia utilizzata nella ricerca: La cultura del counseling e il counselor REICO. Una prima ricerca sociologica sul panorama italiano. Nel contesto internazionale il counseling è considerata un’attività per la promozione e la crescita della persona, come afferma Thomas. L’indagine adotta il punto di vista del social behavior approach ispirato a Roger Straus che colloca l’azione del counselor nella prospettiva del facilitatore che aiuta i soggetti a contestualizzare la loro situazione, elaborare una strategia di azione e avviare una sua realizzazione. La metodologia della ricerca utilizza lo strumento del diamante culturale di Wendy Griswold per strutturare le interviste che poi saranno analizzate con il supporto di NVivo. Sono presentate, infine, le caratteristiche sociodemografiche dei counselor intervistati.

The chapter outlines the theoretical framework and methodology used in the research: Counseling culture and the REICO counselor. An initial sociological survey of the Italian landscape. In the international context, counseling is considered an activity for the promotion and growth of the person, as Thomas states. The survey adopts the viewpoint of the social behavior approach inspired by Roger Straus, which places the counselor's action in the perspective of the facilitator who helps subjects contextualize their situation, elaborate an action strategy and initiate its implementation. The research methodology uses Wendy Griswold's cultural diamond tool to structure the interviews, which will then be analyzed with the support of NVivo. Finally, the sociodemographic characteristics of the counselors interviewed are presented.
description: La cultura del counseling e il counselor REICO. Una prima ricerca sociologica sul panorama italiano
Genome size variation and whole-genome duplications in the monocot order Poales
Creators: name: Winterfeld, Grit
name: Tkač, Natalʹja V.
name: Röser, Martin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 580

description: Nuclear genome sizes of 54 representative species from 44 genera of the monocot order Poales were investigated by flow cytometry. Small holoploid genomes with < 2 pg/2C are characteristic of the Poales; only some families have larger 2C values, although this is not consistently the case. The sizes of monoploid genomes as well as mean DNA content per chromosome (MC) show a similar pattern. A comparison of the genome size data with current molecular phylogenetic data suggests that small monoploid genomes (1Cx < 0.4 pg) and small chromosomes (MC ≤ 0.05 pg), as found in some families, are likely the ancestral features of the order Poales. Conspicuous increases in genome size occurred particularly in the Poaceae (grasses) and to a lesser extent in the xyrid clade and the Restionaceae. According to previous phylogenomic studies, the Poaceae are characterized by a whole-genome duplication (WGD) called ρ, which is absent in all other Poales families. However, it is clear from the 1Cx values that the ρ event is not, or no longer, associated with a significant increase in the minimum 1Cx genome sizes of grasses compared to other Poales families. Future studies need to clarify whether the smallest 1Cx values in the Poaceae are due to a secondary reduction of the nuclear genome after the ρ event and whether the relatively large minimal 1Cx values of the xyrid clade were caused by a further WGD within Poales.
sj-docx-1-jpx-10.1177_23743735221113053 - Supplemental material for Assessment of Social Trust in Relatives of Discharged Patients With Personal Consent and Other Relatives of Patients
Creators: name: Bagi, Hamid Reza Moretza
name: Khamnian, Zhila
name: Hatami, Forough
name: Vahdati, Samad Shams
name: Yazdani, Reza
name: Rahnemayan, Sama
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Medicine

description: Supplemental material, sj-docx-1-jpx-10.1177_23743735221113053 for Assessment of Social Trust in Relatives of Discharged Patients With Personal Consent and Other Relatives of Patients by Hamid Reza Moretza Bagi, Zhila Khamnian, Forough Hatami, Samad Shams Vahdati, Reza Yazdani and Sama Rahnemayan in Journal of Patient Experience
Glucagon can increase force of contraction via glucagon receptors in the isolated human atrium
Creators: name: Neumann, Joachim
name: Schmidt, Franziska
name: Hofmann, Britt
name: Gergs, Ulrich
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Glucagon can increase the force of contraction (FOC) in, for example, canine hearts. Currently, whether glucagon can also increase the FOC via cAMP-increasing receptors in the human atrium is controversial discussed. Glucagon alone did not (up to 1 µM) raise the FOC in human right atrial preparations (HAP). Only in the additional presence of the phosphodiesterase (PDE) 3 inhibitor cilostamide (1 µM) or 1 nM isoprenaline did glucagon raise the FOC, starting at 1 µM. The positive inotropic effects of glucagon in HAP were attenuated by a glucagon receptor antagonist (1 µM SC203972), but not by 100 nM exendin(9-39), a glucagon-like peptide-1 receptor (GLP-1R) antagonist. Glucagon (in the presence of cilostamide) demonstrated a reduced efficacy in elevating the FOC in HAP when compared with isoprenaline. In contrast to glucagon, exenatide alone, a GLP-1R agonist, starting at 1 nM, increased the FOC and was more potent and effective than glucagon in raising the FOC in HAP. The effects of exenatide on the FOC were attenuated by exendin(9-39). Hence, glucagon and GLP-1R agonists act functionally via different receptors in the human right atrium. Clinically, these data suggest that endogenous or exogenous glucagon can stimulate glucagon receptors in the human atrium, but only in the presence of PDE inhibitors.
Responsivity of two pea genotypes to the symbiosis with rhizobia and arbuscular mycorrhiza fungi : a proteomics aspect of the "efficiency of interactions with beneficial soil microorganisms" trait
Creators: name: Frolov, Andrej
name: Shumilina, Julia
name: Afshar, Sarah Etemadi
name: Mashkina, Valeria
name: Rhomanovskaya, Ekaterina
name: Lukasheva, Elena
name: Tsarev, Alexander
name: Sulima, Anton S.
name: Shtark, Oksana Y.
name: Ihling, Christian
name: Soboleva, Alena
name: Tichonovič, Igorʹ A.
name: Zhukov, Vladimir A.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 615

description: It is well known that individual pea (Pisum sativum L.) cultivars differ in their symbiotic responsivity. This trait is typically manifested with an increase in seed weights, due to inoculation with rhizobial bacteria and arbuscular mycorrhizal fungi. The aim of this study was to characterize alterations in the root proteome of highly responsive pea genotype k-8274 plants and low responsive genotype k-3358 ones grown in non-sterile soil, which were associated with root colonization with rhizobial bacteria and arbuscular mycorrhizal fungi (in comparison to proteome shifts caused by soil supplementation with mineral nitrogen salts). Our results clearly indicate that supplementation of the soil with mineral nitrogen-containing salts switched the root proteome of both genotypes to assimilation of the available nitrogen, whereas the processes associated with nitrogen fixation were suppressed. Surprisingly, inoculation with rhizobial bacteria had only a minor effect on the root proteomes of both genotypes. The most pronounced response was observed for the highly responsive k-8274 genotype inoculated simultaneously with rhizobial bacteria and arbuscular mycorrhizal fungi. This response involved activation of the proteins related to redox metabolism and suppression of excessive nodule formation. In turn, the low responsive genotype k-3358 demonstrated a pronounced inoculation-induced suppression of protein metabolism and enhanced diverse defense reactions in pea roots under the same soil conditions. The results of the study shed light on the molecular basis of differential symbiotic responsivity in different pea cultivars. The raw data are available in the PRIDE repository under the project accession number PXD058701 and project DOI 10.6019/PXD058701.
sj-doc-4-jpc-10.1177_21501319221112808 – Supplemental material for Healthy Lifestyles Associated With Socioeconomic Determinants in the Older Adult Population
Creators: name: Roldán González, Elizabeth
name: Lerma Castaño, Piedad Rocio
name: Aranda Zemanate, Adriana Yulieth
name: Caicedo Muñoz, Ángela Giovana
name: Bonilla Santos, Gisella
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-doc-4-jpc-10.1177_21501319221112808 for Healthy Lifestyles Associated With Socioeconomic Determinants in the Older Adult Population by Elizabeth Roldán González, Piedad Rocio Lerma Castaño, Adriana Yulieth Aranda Zemanate, Ángela Giovana Caicedo Muñoz and Gisella Bonilla Santos in Journal of Primary Care & Community Health
MIGRATION AND NATAL DISPERSAL IN THE BARN SWALLOW HIRUNDO RUSTICA
Creators: name: SCANDOLARA, CHIARA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The present thesis investigates different aspects of the two main movements of birds - migration and natal dispersal - using the barn swallow Hirundo rustica as an ideal model species.
First, the dissertation provides novel findings about the migration of this long-distance migratory bird, one of the phenomena that have fascinated people since ancient times. I successfully used a new technology, based on light-level ?geolocators?, by which I could gather more information on the migration of barn swallows than it could be collected over more than one century of intense ringing activity of this species. Moreover, the present work also gives an important contribution to the evaluation of possible drawbacks of this technology, for passerines in general, and for aerially insectivorours species, which may be particularly susceptible to geolocator deployment, in particular.
Second, I studied natal dispersal in barn swallows, giving a fundamental contribution to the knowledge of this ecological process from different points of view, and identifying several factors that affect dispersal decisions and that act at different scale and stage of the individual life history.
Both the results on migration and on natal dispersal may have also a great importance in order to plan appropriate conservation measures at the breeding sites and on the wintering grounds. Indeed, several barn swallow geographical populations, including the ones I studied, are declining, probably as a result of diverse factors that act both in breeding and in the wintering areas. The detailed knowledge of the geographical positions and movements in the non-breeding areas and along the migration routes is the first and indispensable step to program interventions of conservation in the wintering areas. In the breeding sites, for instance, I have demonstrated that the presence of livestock is a key factor for the local recruitment of young; so its maintenance in the farms may contribute to buffering the population decline of this species. Hence, my findings on the two topics can have in the future also a practical application for the conservation of the breeding populations of this declining, flagship bird species.
Kramp, Igna Marion, Begegnungen mit den Geheimnissen des Lebens Jesu Christi
Creators: name: Batlogg, Andreas R.
Publisher: name: Theologie und Philosophie
Year: 1970

description: Theologie und Philosophie, Bd. 95 Nr. 4 (2020): Theologie und Philosophie, Band 95, Heft 4
'L'INTERPRETAZIONE GIUDIZIALE DEI TRATTATI INTERNAZIONALI'
Creators: name: COLZANI, EDOARDO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The thesis is devoted to treaty interpretation by international judges. The subject has already been studied in depth by international law?s scholars: this work is an attempt of analysis from the philosophy of law?s perspective. In particular, the thesis focuses on three main topics: the first chapter is devoted to the concept of ?international treaty?, the second chapter is devoted to the question if interpretation is an art or a science and the third chapter concerns the possibility to interpret a treaty using domestic rules of interpretation. These topics allow the author to highlight three different issues:
1) the relationship between international law system and national law systems;
2) the problems related to interpretation of multilingual texts;
3) the problems related to multicultural comunication.
One of the main topic discussed in this work, the more relevant for philosophy of law, concerns the role of article 33 of Vienna Convention on multilingual texts: differently from what international law scholars think, this article, according to the author, is the most important rule of treaty interpretation.
The reason is that the interpreter is obliged to manage/face with languages wich are different from his own native language: in this sense, from the interpretation of a treaty a lot of problems due to linguistic and cultural differences could rise.
Additional file 2 of Complete series method (CSM): a convenient method to reduce daily heterogeneity when evaluating the regeneration time (RT) of insecticide-treated nets (ITNs)
Creators: name: Lugenge, Aidi Galus
name: Odufuwa, Olukayode G.
name: Mseti, Jilly Jackson
name: Swai, Johnson Kyeba
name: Skovmand, Ole
name: Moore, Sarah Jane
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 2. Table S2. Observed regeneration time using WHO procedure: 24-h mortality for Anopheles arabiensis (Kingani strain, resistant) exposed to ITN samples: unwashed longitudinal (UW-L), washed three times longitudinal (WL) and unwashed (UW-C), washed complete series (WC) at 1, 2, 3, 5 and 7 days after washing in cone bioassay.
sj-pdf-1-gpi-10.1177_13684302221108936 – Supplemental material for Positive contact with working-class people reduces personal contribution to inequality
Creators: name: Vázquez, Alexandra
name: Sayans-Jiménez, Pablo
name: López-Rodríguez, Lucía
name: Lois, David
name: Zagefka, Hanna
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-gpi-10.1177_13684302221108936 for Positive contact with working-class people reduces personal contribution to inequality by Alexandra Vázquez, Pablo Sayans-Jiménez, Lucía López-Rodríguez, David Lois and Hanna Zagefka in Group Processes & Intergroup Relations
Supplemental Material - An Analysis of Factors Predicting Post-Traumatic Stress Disorder and Grief Following Comrade Loss
Creators: name: Yehene, Einat
name: Martin, Yossi
name: Goldzweig, Gil
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material for An Analysis of Factors Predicting Post-Traumatic Stress Disorder and Grief Following Comrade Loss by Einat Yehene, Yosef Martin, and Gil Goldzweig in OMEGA - Journal of Death and Dying
ASMA DEL PANIFICATORE: NUOVE STRATEGIE PREVENTIVE, DIAGNOSTICHE E TERAPEUTICHE
Creators: name: MARSILI, CHIARA BEATRICE LUISA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: L'asma da farine � ancora oggi una delle cause pi� frequenti di asma professionale in molti paesi. Si tratta della manifestazione pi� grave negli esposti a farine che possono presentare anche rinite, congiuntivite e dermatite. La polvere di farina, alcuni contaminanti e additivi sono causa delle varie manifestazioni. Ad oggi molti aspetti delle patogenesi restano da chiarire, cos� come nuovi test diagnostici e nuove terapie devono essere validate. Il presente progetto di ricerca di dottorato si � sviluppato su un doppio binario:
1) adozione di tests di provocazione nasale specifici con estratti di farina purificati e standardizzati (Lofarma Allergeni), monitorando le resistenze nasali e la funzionalit� respiratoria. I soggetti per i quali viene formulata una diagnosi di allergopatia respiratoria da farina di frumento sono sottoposti ad immunoterapia sublinguale.
2) Definizione dei polimorfismi genetici dei recettori TLR-4/+896 e CD14/-159 delle endotossine batteriche che sono presenti come contaminanti nelle farine e possono favorire la risposta immunitaria, nonch� il dosaggio delle interleuchine IL6, IL8 e TNF ?, e della frazione espirata di ossido nitrico (FeNO) identificati come markers di infiammazione che possono variare nelle popolazioni di lavoratori esposti a farina di frumento.
Lo studio clinico ha permesso di testare gli estratti di farine impiegati nel test di provocazione nasale specifico, metodica che si � rivelata fondamentale per la diagnosi di alcuni casi di malattia professionale e che in futuro potr� verosimilmente essere utilizzata per la stimolazione bronchiale; l?immunoterapia specifica ha fornito risultati pi� che soddisfacenti in termini di miglioramento dei sintomi e di proseguimento dell?attivit� lavorativa. Lo studio biochimico eseguito su una popolazione di 167 panificatori suddivisi tra malati professionali, atopici e sani ha permesso di chiarire meglio il ruolo delle interleuchine e dei recettori per le endotossine nella patogenesi dell?asma professionale, fornendo spunti interessanti in termini di monitoraggio e prevenzione della patologia.
Long-term social memory of mate copying in Drosophila melanogaster is localized in mushroom bodies
Creators: name: Nöbel, Sabine
name: Danchin, Etienne
name: Isabel, Guillaume
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 590

description: Long-term social memory (LTSM) is a key feature to elicit the cultural inheritance of behaviour independently of genetics. However, the neurobiological basis of LTSM remains largely unknown. We previously used the Drosophila animal model, which is known to perform mate copying through observational learning of the mate choice of conspecifics to show that the expression of the rutabaga gene, a calcium/calmodulin-dependent adenylyl cyclase (AC-Rut+) that acts as a coincidence detector enabling associative learning, is necessary and sufficient in the γ-Kenyon cells (KCs) of the mushroom bodies (MBs). Here, we show that the expression of AC-Rut+ in both the γ- and the α/β-KCs is required for LTSM involving de novo protein synthesis in a mate-copying context, whether using demonstrations involving real flies or involving pictures of copulating conspecifics. Thus, pathways of short- and long-term memory show considerable overlap in the MBs across social vs. asocial learning contexts.
LA RIDEFINIZIONE DEL CONCETTO DI SUBORDINAZIONE IN ITALIA E IN EUROPA
Creators: name: BARBERIS, FILIPPO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: La ridefinizione della nozione di subordinazione nel diritto italiano
Attraverso la ricostruzione del dibattito italiano intorno al concetto di subordinazione nel diritto del lavoro, la presente tesi di ricerca si propone di enucleare i diversi problemi davanti ai quali sia il legislatore sia l?interprete del diritto devono misurarsi nel tentativo di ridefinire l?area del lavoro dipendente nel nostro ordinamento. Questa esigenza di ridefinizione, richiamata da pi� voci, almeno a partire dagli anni Ottanta del secolo scorso, oggi sembra stentare a trovare una forma stabile sulla quale il diritto del lavoro possa svilupparsi negli anni a venire.
Osservare con attenzione l?evoluzione del concetto di subordinazione, l?intenso dibattito dottrinale che introno a questa nozione si � sviluppato nel tempo, gli orientamenti della giurisprudenza, le soluzioni legislative attuate e anche quelle solo proposte, pu� fornire elementi preziosi per leggere criticamente lo stato attuale del dibattito in materia con l?obiettivo di ricercare le soluzioni pi� efficaci ad enucleare un concetto di lavoro dipendente capace di rispondere in maniera adeguata alle esigenze qualificatorie e di tutela dell?attuale mercato del lavoro.
La tesi che in questo lavoro si intende sostenere � la seguente: una ?equilibrata? definizione di subordinazione, capace di resistere alla ?tempesta di interessi? che caratterizza il mercato del lavoro, non pu� poggiare esclusivamente su una valutazione tecnico-giuridica relativa alla scelta degli elementi definitori della fattispecie e al metodo adottato nella qualificazione del rapporto, ma deve tener conto delle conseguenze sociali ed economiche che produrr� nella sua applicazione. Solo attraverso questa valutazione socio-economica dell?impatto della ridefinizione della fattispecie sar� infatti possibile individuare una disciplina applicabile ?sostenibile?, ossia in grado di evitare nella propria applicazione effetti patologici come la ?istituzionalizzazione? delle forme di lavoro precario o, peggio ancora, l?incentivazione del lavoro irregolare.
Una ridefinizione del concetto di subordinazione che produca un?espansione dell?area della disciplina applicabile dovr� cos� confrontarsi con l?esigenza di rimodulare il sistema di protezione del lavoro dipendente, rendendolo pi� flessibile nel rapporto e pi� intenso nel mercato. Maggiori saranno gli elementi di contesto favorevoli al datore di lavoro, pensiamo alle azioni di semplificazione normativa o di riduzione della pressione fiscale da parte del legislatore, maggiore sar� la possibilit� di rendere ?economicamente compatibile? un?efficace assetto di tutele per il lavoratore.
Additional file 4 of The influence of oviposition status on measures of transmission potential in malaria-infected mosquitoes depends on sugar availability
Creators: name: Shiau, Justine C.
name: Garcia-Diaz, Nathan
name: Kyle, Dennis E.
name: Pathak, Ashutosh K.
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 4: Table S2. Pairwise comparisons (post hoc) of the estimated marginal means in sporozoite prevalence predicted by the statistical model in Table 1 (‘y = sporozoite prevalence’) (Fig. 1A). Comparisons were made between each of the four groups (oviposited and nutrient treatments) for the indicated day post-infection. Estimates (‘Est. (= A-B)’) indicate the difference of the predicted mean in group B subtracted from that of group A. Tukey’s method was used to adjust for multiple comparisons.
Effectiveness trade-off between green spaces and built-up land : evaluating trade-off efficiency and its drivers in an expanding city
Creators: name: Dong, Xinyu
name: Ye, Yanmei
name: Zhou, Tao
name: Haase, Dagmar
name: Lausch, Angela
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 550

description: Urban expansion encroaches on green spaces and weakens ecosystem services, potentially leading to a trade-off between ecological conditions and socio-economic growth. Effectively coordinating the two elements is essential for achieving sustainable development goals at the urban scale. However, few studies have measured urban–ecological linkage in terms of trade-off. In this study, we propose a framework by linking the degraded ecological conditions and urban land use efficiency from a return on investment perspective. Taking a rapidly expanding city as a case study, we comprehensively quantified urban–ecological conditions in four aspects: urban heat island, flood regulating service, habitat quality, and carbon sequestration. These conditions were assessed on 1 km2 grids, along with urban land use efficiency at the same spatial scale. We employed the slack-based measure model to evaluate trade-off efficiency and applied the geo-detector method to identify its driving factors. Our findings reveal that while urban–ecological conditions in Zhengzhou’s periphery degraded over the past two decades, the inner city showed improvement in urban heat island and carbon sequestration. Trade-off efficiency exhibited an overall upward trend during 2000–2020, despite initial declines in some inner city areas. Interaction detection demonstrates significant synergistic effects between pairs of drivers, such as the Normalized Difference Vegetation Index and building height, and the number of patches of green spaces and the patch cohesion index of built-up land, with q-values of 0.298 and 0.137, respectively. In light of the spatiotemporal trend of trade-off efficiency and its drivers, we propose adaptive management strategies. The framework could serve as guidance to assist decision-makers and urban planners in monitoring urban–ecological conditions in the context of urban expansion.
CAUSES AND CONSEQUENCES OF REDUCED EXPRESSION OF SNAP-25 IN NEURONAL NETWORKS
Creators: name: DE ASTIS, SILVIA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Synaptosomal-associated protein of 25 kDa (SNAP-25) is a protein that participates in the regulation of synaptic vesicle exocytosis and modulates voltage-gated calcium channels activity. Altered levels of SNAP-25 expression have been associated to different neurological and neuropsychiatric conditions, such as schizophrenia, ADHD, and bipolar disorder, and lower levels of SNAP-25 have been described in patients with schizophrenia. I used Snap-25 heterozygous (Snap-25+/?) mice, expressing reduced levels of SNAP-25, to investigate at which extent the reduction of the protein expression affects neuronal network function and mouse behaviour. Snap-25+/? mice displayed a moderate hyperactivity, which disappeared in the adult animals and showed an impairment in associative learning and recognition memory. Electroencephalographic recordings revealed the occurrence of frequent spikes, suggesting a diffuse network hyperexcitability. Moreover, SNAP-25+/? mice displayed higher susceptibility to kainate-induced seizures. Notably, treatment with antiepileptic drugs improve both EEG profile and cognitive defects. The abnormal EEG profile observed in SNAP-25+/- mice could contribute to the learning and memory defects. Based on the results i have obtained, showing the occurrence of cognitive disabilities in mice expressing reduced levels of SNAP-25 i conducted a functional analysis on SNP rs363050, which associates with low performance IQ and is located on intron 1 of the Snap-25 gene, to investigate whether the presence of the parental or minor allele may affect the expression of SNAP-25. The presence of minor allele resulted in a reduction of the transcription capability, while the parental allele did not increase the basal activity of an heterologous promoter. These results indicate that reduction of SNAP-25 expression is associated to generation of epileptiform discharges and cognitive dysfunctions, which can be effectively treated by antiepileptic drugs and support the evidence that the rs363050 polymorphism might have a role in modulating Snap-25 gene expression levels.
SERVIZI DI INTERESSE ECONOMICO GENERALE E DIRITTO DELLA CONCORRENZA NELL'UNIONE EUROPEA
Creators: name: BOTTI, ELISABETTA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: My dissertation deals with the topic of Services of general economic interest (SGEIs) in the European Union. The research is mainly focused on competition and State aid law aspects, in order to understand whether and to what extent an economic activity carried out by an undertaking entrusted with a public mission can be exempted from the application of competition law rules. The thesis primarily focuses on the definition of ?Services of general economic interest?, which differs from the national concepts of ?public service?. After an analysis of the pertinent case-law, it will be held that such a notion represents a balance between economic and social concerns on one hand, and between national and EU competence on the other. The dissertation then proceeds to examine the State aid rules applicable to SGEIs: it will deal in particular with the conditions of admissibility of public funding in this sector, as set out by the Court's case-law and by the Commission?s decision making practice. Lastly, in the final part of the dissertation, the new Treaty legal basis relating these services will be analyzed, in order to understand whether a greater attention to social aspects has developed (or should develop) in this field.
BioNetLink : an architecture for working with network data
Creators: name: Klapperstück, Matthias
name: Schreiber, Falk
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2014
Subjects: subject: 004

description: The visualization of biological data gained increasing importance in the last years. Thereis a large number of methods and software tools available that visualize biological dataincluding the combination of measured experimental data and biological networks. Withgrowing size of networks their handling and exploration becomes a challenging task forthe user. In addition, scientists also have an interest in not just investigating a single kindof network, but on the combination of different types of networks, such as metabolic, generegulatory and protein interaction networks. Therefore, fast access, abstract and dynamicviews, and intuitive exploratory methods should be provided to search and extract infor-mation from the networks.This paper will introduce a conceptual framework for handling and combining multiplenetwork sources that enables abstract viewing and exploration of large data sets includingadditional experimental data. It will introduce a three-tier structure that links networkdata to multiple network views, discuss a proof of concept implementation, and shows aspecific visualization method for combining metabolic and gene regulatory networks in anexample.
DIFFERENT SCALE MODELING FOR CROWD DYNAMICS AND MULTI-TEMPERATURE GAS MIXTURES
Creators: name: MARTALO', GIORGIO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: In the first part of this work we want to propose a model able to reproduce correctly the dynamics of a crowd in bounded domains (for example rooms and corridors) and in presence of obstacles, and also to discuss the emergence of some behaviors induced by panic. Starting from the analysis of a microscopic description for a small crowd one can deduce some mesoscopic and macroscopic models when the number of agents increases and the crowd is more comparable to gases and fluids. In the second part we want to propose some multi-temperature models for gas mixtures by means of standard tools of kinetic theory. Some descriptions are proposed also in presence of chemical reactions and of an internal structure for molecules to take non-translational degrees of freedom into account. The resulting models are tested on the classical problem of the steady shock wave and the occurence of smooth solutions and sub-shocks is discussed for varying parameters.
Making sense of science in the 21st century: A personal view
Creators: name: Policy Labs, Frontiers
Publisher: name: Frontiers
Year: 2024
Subjects: Science Policy
Research, Science and Technology Policy

description:  
“Making sense” of a particular domain at the level of an individual or a group of individuals is an act that results from a dynamic interaction between related stakeholders, influenced by their socio-economic and political environment. As such, there is room for subjective judgement and differing interpretations, as well as the potential for change over time. 

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sj-docx-1-bbs-10.1177_23727322221144650 - Supplemental material for Data Exclusion in Policy Survey and Questionnaire Data: Aberrant Responses and Missingness
Creators: name: Hong, Maxwell
name: Carter, Matthew
name: Kim, Casey
name: Cheng, Ying
Publisher: name: SAGE Journals
Year: 2023
Subjects: Psychology not elsewhere classified
Public Administration

description: Supplemental material, sj-docx-1-bbs-10.1177_23727322221144650 for Data Exclusion in Policy Survey and Questionnaire Data: Aberrant Responses and Missingness by Maxwell Hong, Matthew Carter, Casey Kim and Ying Cheng in Policy Insights from the Behavioral and Brain Sciences
Additional file 1 of Effect of probiotics on children with autism spectrum disorders: a meta-analysis
Creators: name: Zeng, Ping
name: Zhang, Cheng-zhi
name: Fan, Zhi-xing
name: Yang, Chao-jun
name: Cai, Wan-yin
name: Huang, Yi-fan
name: Xiang, Zu-jin
name: Wu, Jing-yi
name: Zhang, Jing
name: Yang, Jian
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary Material 1
Nutrilyzer : a tool for deciphering atomic stoichiometry of differentially expressed paralogous proteins
Creators: name: Lotz, Katrin
name: Schreiber, Falk
name: Wünschiers, Röbbe
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: 004

description: Organisms try to maintain homeostasis by balanced uptake of nutrients from their envi- ronment. From an atomic perspective this means that, for example, carbon:nitrogen:sulfur ratios are kept within given limits. Upon limitation of, for example, sulfur, its acquisition is triggered. For yeast it was shown that transporters and enzymes involved in sulfur up- take are encoded as paralogous genes that express different isoforms. Sulfur deprivation leads to up-regulation of isoforms that are poor in sulfur-containing amino acids, that is, methinone and cysteine. Accordingly, sulfur-rich isoforms are down-regulated. We developed a web-based software, doped Nutrilyzer, that extracts paralogous protein coding sequences from an annotated genome sequence and evaluates their atomic compo- sition. When fed with gene-expression data for nutrient limited and normal conditions, Nutrilyzer provides a list of genes that are significantly differently expressed and simul- taneously contain significantly different amounts of the limited nutrient in their atomic composition. Its intended use is in the field of ecological stoichiometry. Nutrilyzer is available at http://nutrilyzer.hs-mittweida.de. Here we describe the work flow and results with an example from a whole-genome Ara- bidopsis thaliana gene-expression analysis upon oxygen deprivation. 43 paralogs dis- tributed over 37 homology clusters were found to be significantly differently expressed while containing significantly different amounts of oxygen.
Petzel, Paul / Reck, Norbert (Hrsg.), Von Abba bis Zorn Gottes
Creators: name: Batlogg, Andreas R.
Publisher: name: Theologie und Philosophie
Year: 1970

description: Theologie und Philosophie, Bd. 95 Nr. 4 (2020): Theologie und Philosophie, Band 95, Heft 4
Impactos do TDAH na Aprendizagem e no Desenvolvimento Infantil: Uma Revisão Abrangente
Creators: name: Baptista, Bárbara Cazé
name: Oliveira, Edna Margareth Pereira Rocha Oliveira
name: Tavares, Ivone Maria Bolzan Rodrigues
name: Silva, Maria Elise Barbosa
Publisher: name: Zenodo
Year: 2024

description: O Transtorno do Déficit de Atenção com Hiperatividade (TDAH) é um transtorno neurobiológico que afeta a aprendizagem e o desenvolvimento das crianças. Este artigo revisa os efeitos do TDAH sobre o desempenho acadêmico, as interações sociais e o desenvolvimento emocional. As crianças com TDAH frequentemente enfrentam dificuldades significativas na escola devido à desatenção, hiperatividade e impulsividade, o que compromete sua capacidade de concentração, organização e controle comportamental. Além das dificuldades acadêmicas, essas crianças podem experimentar desafios nas relações sociais, como rejeição e baixa autoestima. Intervenções precoces e adaptadas, como programas de treinamento em habilidades sociais e suporte acadêmico personalizado, têm mostrado eficácia em mitigar esses impactos. A colaboração entre profissionais de saúde, educadores e pais, bem como o uso de tecnologias assistivas, é fundamental para oferecer um suporte abrangente e coordenado. O levantamento bibliográfico foi realizado nas bases de dados eletrônicas: National Library of Medicine (Medicine–PubMed), ScientificElectronic Library Online (SciELO) e Google Acadêmico. Foram utilizados os seguintes descritores: Educação, TDAH, aprendizagem, desenvolvimento infantil , bem como tais descritores em inglês:  

As buscas não foram refinadas para um período específico. Algumas bases permitiam o filtro “texto completo”. Não houve restrição quanto ao idioma de publicação, data de publicação ou local do estudo.
sj-docx-1-ems-10.1177_14690667231164096 - Supplemental material for Exploratory data fusion of untargeted multimodal LC-HRMS with annotation by LCMS-TOF-ion mobility: White wine case study
Creators: name: Mafata, Mpho
name: Stander, Maria
name: Masike, Keabetswe
name: Buica, Astrid
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-ems-10.1177_14690667231164096 for Exploratory data fusion of untargeted multimodal LC-HRMS with annotation by LCMS-TOF-ion mobility: White wine case study by Mpho Mafata, Maria Stander, Keabetswe Masike and Astrid Buica in European Journal of Mass Spectrometry
Cardiac manifestations in adult MELAS syndrome (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome) : a cross-sectional study
Creators: name: Stoevesandt, Dietrich
name: Schlitt, Axel
name: Röntgen, Philipp Konrad
name: Kraya, Torsten
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Backround: Cardiac involvement has been reported in different mitochondrial geno- and phenotypes, including mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like (MELAS) syndrome. However, cardiac manifestations are diverse and not well described. Methods: We prospectively examined cardiac manifestations in 11 adult patients with MELAS syndrome harboring the MTTL1 m.3243A < G-mutation using patient records, cardiac MRI (1.5 Tesla), echocardiography, electrocardiogram (ECG), laboratory tests of cardiac markers (CK, CK-MB, Trop I, BNP), and clinical severity (NMDAS = Newcastle Mitochondrial Disease Scale). Results: Among 11 consecutive patients with MELAS syndrome (73% male, mean age 37.5 ± 10.6 years) cardiac manifestations were found in nine (82%). Pathology was mainly detected using MRI (9 of 11, 82%). Six patients showed diffuse late enhancement in the left ventricle, one a left ventricular ejection fraction (LVEF) below 30%, two with a LVEF in the range of 40–50% in the cardiac MRI, and another five patients presenting diastolic dysfunction as defined by echocardiography. Only one patient with late enhancement on MRI also showed a conduction block in the ECG. There was no correlation between the cardiac manifestations and the NMDAS score or heteroplasmy grade. Conclusions: Cardiac involvement in MELAS syndrome harboring the MTTL1 m.3243A > G mutation mostly entails cardiomyopathy, which was particularly evident in the cardiac MRI. Only one patient (1/11, 9.1%) had conduction defects. Thus, cardiac testing including cardiac MRI, echocardiography and ECG seems to be important for prognosis of MELAS patients.
Identification and characterization of eukaryotic pathogens' sodium and chloride-dependent Gamma-aminobutyric Acid (GABA) transporters
Creators: name: Otarigho Benson
name: Mofolusho O. Falade
Publisher: name: F1000Research
Year: 2017

description: Gamma-aminobutyric Acids (GABAs) are known to function as inhibitory neurotransmitter and excitatory neurotransmitters in most eukaryotic pathogens. However, GABA transporters in most pathogens have not been identified and characterized. The increasing number of sequenced organism genomes has made the identification of chemotherapeutic targets for development of target-based drug designs a possibility. We have explored completed eukaryotic pathogen genomes for GABA transporter proteins, which have been identified as probable targets for drugs. We identified 8 proteins that spread across 4 phyla in 5 different pathogen species, which include Eimeria mitis Houghton, Neospora caninum Liverpool, S. mansoni, S. haematobium and Trichinella spiralis. Sub-cellular localization prediction revealed that these proteins are mostly soluble integral membrane proteins. About 81% of these proteins are non-crystallizable, while 15% are crystallizable. Transmembrane helices predictions show that the GABA transporters have 10, 11, 12 and 14 TMHs. We have identified for the first time parasite GABA transporters from eukaryotic parasite genomes describing their relationship and phylogeny. Our study represents an effort to understand the function and mechanism of action of GABA transporters in these pathogens as well as offer new targets for drug development against parasitic diseases.
title: Antenatal diagnosis of iniencephaly clausus with cystic hygroma
Creators: name: Hosamani, Kavyashree
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Genital (female) imaging
subject: Foetal imaging
subject: Neuroradiology spine
subject: Ultrasound
subject: Foetus
subject: Obstetrics
subject: Clinical Case

description: Clinical History: A 22-year-old primigravida visited the antenatal clinic with complaints of 5 months of amenorrhea. The patient was referred to the Department of Radiodiagnosis for a routine antenatal scan. There was no history of consanguinity, fever, or teratogen exposure in the patient. It was an unplanned pregnancy. The patient is not on folic acid supplementation. The patient had not had any previous antenatal scans.

description: 22 years, female
POST-TRANSCRIPTIONAL REGULATION IN GRAM NEGATIVE BACTERIA
Creators: name: DELVILLANI, FRANCESCO
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Post-transcriptional regulation plays a pivotal role in gene expression control as it ensures a fast response to environmental changes. This is particularly important in unicellular organisms that are exposed to environmental changes. During my PhD, I studied different aspects of this type of regulation in two Gram-negative bacteria: Escherichia coli and the opportunistic pathogen Pseudomonas aeruginosa. In E. coli I investigated the role of the ribosomal protein S1 in the interplay between translation and mRNA decay. In particular we showed that S1 not associated to 30S can sequester and protect mRNA from RNase E, the main endonuclease in E. coli. Another aspect that I considered in my research has been regulation by RNA molecules in P. aeruginosa. In the last decade, it has become clear how RNA-based regulatory mechanisms are important in controlling bacterial gene expression. However, little is known about it in this relevant human pathogen. By RNA deep sequencing we identified more than 150 novel candidate sRNAs in the P. aeruginosa strains PAO1 and PA14, which differ in virulence degree. We confirmed by Northern blotting the expression of 52 new sRNAs, substantially increasing the number of known sRNAs expressed by this bacterium. In this context we developed a genetic screen for the identification of genes post-transcriptionally regulated by RNA determinants and applied this system to the search of RNA thermometers (RNATs), i.e. mRNA determinants that couple translation with temperature changes. We identified four putative RNATs and validated two of them in E. coli. Interestingly, the two are located upstream of genes previously implicated in P. aeruginosa pathogenesis, namely dsbA and ptxS. ptxS RNAT was validated also in P. aeruginosa and represents the first RNAT ever described in this bacterium.