cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Aspirin as a potential drug repurposing candidate targeting estrogen receptor alpha in breast cancer: a molecular dynamics and in-vitro study
Creators: name: Kaur, Deepinder
name: Choudhury, Chinmayee
name: Yadav, Reena
name: Kumari, Laxmi
name: Bhatia, Alka
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Estrogen receptor alpha (ERα) is expressed by 70% of breast cancers (BCs). Any deregulation in ERα signaling is crucial for the initiation and progression of BC. Because of development of resistance to anti-estrogenic compounds, repurposing existing drugs is an apt strategy to avoid a long drug-discovery process. Substantial epidemiologic evidence suggests that Aspirin use reduces the risk of different cancers including BC, while its role as an adjuvant or a possible antineoplastic agent in cancer treatment is being investigated. In this study, we attempted to explore possibilities of ERα inhibition by Aspirin which may act through competitive binding to the ligand binding domain (LBD) of ERα. A list of 48 ERα-LBD crystal structures bound with agonists, antagonists, and selective ER modulators (SERMs) was thoroughly analysed to determine interaction patterns specific to each ligand category. Exhaustive docking and 500 ns molecular dynamics (MD) studies were performed on three ERα - Aspirin complexes generated using agonist, antagonist, and SERM-bound crystal structures. Besides, three ERα crystal structures bound to agonist, antagonist, and SERM respectively were also subjected to MD simulations. Aspirin showed good affinity to LBD of ERα. Comparative analyses of binding patterns, conformational changes and molecular interaction profiles from the docking results and MD trajectories suggests that Aspirin was most stable in complex generated using SERM bound crystal structure of ERα and showed interactions with Gly-521, Ala-350, Leu-525 and Thr-347 like SERMs. In addition, in-vitro assays, qPCR, and immunofluorescent assay demonstrated the decline in the expression of ERα in MCF-7 upon treatment with Aspirin. These preliminary bioinformatical and in-vitro findings may form the basis to consider Aspirin as a potential candidate for targeting ERα, especially in tamoxifen-resistant cancers.
The connection between single transverse spin asymmetries and the second moment of $g_2$
Creators: name: Ehrnsperger, B.
name: Schaefer, A.
name: Greiner, W.
name: Mankiewicz, L.
Publisher: name: arXiv
Year: 1993
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We point out that the size of the photon single spin asymmetry in high--energy proton proton collisions with one transversely polarized proton can be related to $d^{(2)}$, the twist three contribution to the second moment of $g_2$. Both quantities should be measured in the near future. The first was analysed by Qiu and Sterman, the second was estimated by Balitsky, Braun, and Kolesnichenko. Both experiments measure effectively the strength of the collective gluon field in the nucleon oriented relative to the nucleon spin. The sum rule results suggest that the single spin asymmetry is rather small for the proton, but could be substantial for the neutron.
description: 6 pages, UFTP preprint 348/1993
Lychnothamnus grambastii Soulie-Marsche 1989
Creators: name: Sanjuan, Josep
name: Martín-Closas, Carles
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Plantae
Charophyta
Charophyceae
Charales
Characeae
Lychnothamnus
Lychnothamnus grambastii

description: Lychnothamnus grambastii (Feist-Castel, 1971) Soulié-Märsche, 1989
(Fig. 8 A-C)
Stephanochara grambastii Feist-Castel, 1971: 166-168, pl. 11, figs. 1-5.
Lychnothamnus grambastii – Soulié-Märsche 1989: 160.
DISTRIBUTION. — Lychnothamnus grambastii was previously reported from its type locality in the Lower to Middle Priabonian of the Alés Basin, southern France (Feist-Castel 1971). In the Ebro Basin, this species has been reported in many samples from the Torre Casanova (Moià) locality (Table 2). Ŋe new data not only widen its distribution to the south but also its biostratigraphic range, reaching now the Upper Priabonian, since it occurs in association with Harrisichara tuberculata.
DESCRIPTION
Medium to large gyrogonite, variable in size, 667- 1000 µm high (mean 850 µm), and 560-859 µm in width (mean 703 µm), normally inversed pearshaped to ellipsoidal with an isopolarity index of 100-144 (mean 120). Spiral cells 100 µm wide, convex and smooth. Eight to ten (frequently nine), convolutions are visible laterally. Apex flat or slightly convex. Spiral cells display marked thinning resulting in a periapical depression. Apex ornamented by tubercles, frequently comma shaped and about 80 M m high and 100 M m wide. Base slightly conical with large basal pore, about 80 µm across, and located within a well-marked funnel.
REMARKS
Lychnothamnusgrambastii showssimilardimensionsand morphology to Lychnothamnus edwardsii (Grambast, 1958) Soulié-Märsche, 1989 with both species having apical nodules and a basal funnel. However, whereas Lychnothamnus grambastii shows a slightly pointed base which finishes in a well-marked and wide funnel, Lychnothamnus edwardsii shows a rounded base with a superficial basal funnel. Also, Lychnothamnus grambastii does not show a periapical constriction which occurs in Lychnothamnus edwardsii.
description: Published as part of Sanjuan, Josep & Martín-Closas, Carles, 2014, Taxonomy and palaeobiogeography of charophytes from the Upper Eocene- Lower Oligocene of the Eastern Ebro Basin (Catalonia, NE Spain), pp. 385-420 in Geodiversitas 36 (3) on pages 402-404, DOI: 10.5252/g2014n3a3, http://zenodo.org/record/4538531
On the Hamiltonian-Krein index for a non-self-adjoint spectral problem
Creators: name: Kostenko, Aleksey
name: Nicolussi, Noema
Publisher: name: arXiv
Year: 2017
Subjects: subject: Spectral Theory (math.SP)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: We investigate the instability index of the spectral problem $$ -c^2y'' + b^2y + V(x)y = -\mathrm{i} z y' $$ on the line $\mathbb{R}$, where $V\in L^1_{\rm loc}(\mathbb{R})$ is real valued and $b,c>0$ are constants. This problem arises in the study of stability of solitons for certain nonlinear equations (e.g., the short pulse equation and the generalized Bullough-Dodd equation). We show how to apply the standard approach in the situation under consideration and as a result we provide a formula for the instability index in terms of certain spectral characteristics of the 1-D Schrödinger operator $H_V=-c^2\frac{d^2}{dx^2}+b^2 +V(x)$.
description: 15 pages; to appear in Proc. Amer. Math. Soc
INTEGRAL discovery of non-thermal hard X-ray emission from the Ophiuchus cluster
Creators: name: Eckert, D.
name: Produit, N.
name: Paltani, S.
name: Neronov, A.
name: Courvoisier, T. J. -L.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of deep observations of the Ophiuchus cluster of galaxies with INTEGRAL in the 3-80 keV band. We analyse 3 Ms of INTEGRAL data on the Ophiuchus cluster with the IBIS/ISGRI hard X-ray imager and the JEM-X X-ray monitor. In the X-ray band using JEM-X, we show that the source is extended, and that the morphology is compatible with the results found by previous missions. Above 20 keV, we show that the size of the source is slightly larger than the PSF of the instrument, and is consistent with the soft X-ray morphology found with JEM-X and ASCA. Thanks to the constraints on the temperature provided by JEM-X, we show that the spectrum of the cluster is not well fitted by a single-temperature thermal Bremsstrahlung model, and that another spectral component is needed to explain the high energy data. We detect the high energy tail with a higher detection significance (6.4 sigma) than the BeppoSAX claim (2 sigma). Because of the imaging capabilities of JEM-X and ISGRI, we are able to exclude the possibility that the excess emission comes from very hot regions or absorbed AGN, which proves that the excess emission is indeed of non-thermal origin. Using the available radio data together with the non-thermal hard X-ray flux, we estimate a magnetic field B ~ 0.1-0.2 mu G.
description: 8 pages, 9 figures, accepted by A&A
Manual wheelchair tilt-rest skill: a cross-sectional survey of awareness and capacity among wheelchair users
Creators: name: R. Lee Kirby
name: Aggour, Amira
name: Chen, Audrey
name: Smith, Cher
name: Theriault, Chris
name: Matheson, Kara
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Purpose: The tilt-rest skill consists of tipping the wheelchair back and allowing it to rest against a solid object with the wheel locks applied (e.g., for pressure redistribution, neck comfort or hands-free activities). The objective of this study was to determine the proportion of experienced manual wheelchair users who are aware of this skill and who can perform it. Materials and methods: We conducted a cross-sectional survey of 49 manual wheelchair users using a questionnaire developed for the purpose. The tilt-rest skill was attempted by those who reported that they were capable of performing it. Results: Participants’ mean (SD) age was 55.1 (18.2) years, 38 (77.6%) were male, their median (IQR) duration of wheelchair use was 2 (7.2) years and their mean (SD) daily time spent in the wheelchair was 9.5 (4.6) hours. Twenty-seven (55.1%) participants were aware of the skill, 19 (38.8%) reported being able to perform the skill and 16 of 47 (34.0%) were able to demonstrate the skill. Multivariate modelling with the question “Can you complete the tilt-rest skill?” as the dependent measure revealed an inverse relationship with age – Odds Ratio (95% Confidence Interval) of 0.476 (0.293, 0.774) (p = .0028) for each 10 year increase in age. Conclusions: Only just over half of manual wheelchair users are aware of the tilt-rest skill and one-third of users can perform it. Older people are less likely to report being able to complete the skill. These findings have implications for wheelchair skills training during the wheelchair-provision process.Implications for RehabilitationOnly just over half of manual wheelchair users are aware of the tilt-rest skill and only about one-third of users can perform it.Older people are less likely to report being able to complete the skill.These findings have clinical implications for wheelchair skills training during the, specifically that clinicians responsible for manual wheelchair-provision process should ensure that appropriate wheelchair users have the opportunity to learn this skill. Only just over half of manual wheelchair users are aware of the tilt-rest skill and only about one-third of users can perform it. Older people are less likely to report being able to complete the skill. These findings have clinical implications for wheelchair skills training during the, specifically that clinicians responsible for manual wheelchair-provision process should ensure that appropriate wheelchair users have the opportunity to learn this skill.
Partition properties of the dense local order and a colored version of Milliken's theorem
Creators: name: Laflamme, C.
name: Van Thé, L. Nguyen
name: Sauer, N. W.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Combinatorics (math.CO)
subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03E02, 05C55, 05D10, 22F05, 22A05

description: We study the finite dimensional partition properties of the countable homogeneous dense local order. Some of our results use ideas borrowed from the partition calculus of the rationals and are obtained thanks to a strengthening of Milliken's theorem on trees.
description: 17 pages, 9 figures. This is the very last version of the paper. Several proofs were simplified and pictures were added
On the Non-Equilibrium Early Universe
Creators: name: Elmfors, P.
name: Enqvist, K.
name: Vilja, I.
Publisher: name: arXiv
Year: 1993
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study non--equilibrium ensemble corrections to particle masses and the effective potential in the early universe, using a uniform momentum distribution as an example. The resulting thermalization temperature is computed assuming \sm degrees of freedom, and it is always found to be below $5\times 10^{14}$ GeV, implying that GUT phase transitions typically take place out of equilibrium. For the abelian Higgs model we find that the phase transition is of second order if it occurs before equilibration, in contrast to the first order equilibrium phase transition.
description: 12 pp. 1 fig, Latex + epsf.sty
Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
Creators: name: Sabt, Ahmed
name: Abdelhafez, Omaima M.
name: El-Haggar, Radwan S.
name: Madkour, Hassan M. F.
name: Wagdy M. Eldehna
name: Ezz El-Din A. M. El-Khrisy
name: Abdel-Rahman, Mohamed A.
name: Laila. A. Rashed
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro evaluation of their growth inhibitory activity towards the proliferation of three cancer cell lines; HepG2 (hepatocellular carcinoma), MCF-7 (breast cancer), and Caco-2 (colon cancer). HepG2 cells were the most sensitive cells to the influence of the target coumarins. Compounds 13a and 15a emerged as the most active members against HepG2 cells (IC50 = 3.48 ± 0.28 and 5.03 ± 0.39 µM, respectively). Compounds 13a and 15a were able to induce apoptosis in HepG2 cells, as assured by the upregulation of the Bax and downregulation of the Bcl-2, besides boosting caspase-3 levels. Besides, compound 13a induced a significant increase in the percentage of cells at Pre-G1 by 6.4-folds, with concurrent significant arrest in the G2-M phase by 5.4-folds compared to control. Also, 13a displayed significant increase in the percentage of annexin V-FITC positive apoptotic cells from 1.75–13.76%. Moreover, QSAR models were established to explore the structural requirements controlling the anti-proliferative activities.
Invariant Amplitudes for Pion Electroproduction
Creators: name: Pasquini, B.
name: Drechsel, D.
name: Tiator, L.
Publisher: name: arXiv
Year: 2007
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The invariant amplitudes for pion electroproduction on the nucleon are evaluated by dispersion relations at constant t with MAID as input for the imaginary parts of these amplitudes. In the threshold region these amplitudes are confronted with the predictions of several low-energy theorems derived in the soft-pion limit. In general agreement with Chiral Perturbation Theory, the dispersive approach yields large corrections to these theorems because of the finite pion mass.
description: 18 pages, 8 figures
Lychnothamnus vectensis Soulie-Marsche 1989
Creators: name: Sanjuan, Josep
name: Martín-Closas, Carles
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Plantae
Charophyta
Charophyceae
Charales
Characeae
Lychnothamnus
Lychnothamnus vectensis

description: Lychnothamnus vectensis (Groves, 1926) Soulié-Märsche, 1989
(Fig. 8 D-G)
Chara vectensis Groves, 1926: 172, pl. 2, figs 2-8.
Stephanochara vectensis – Grambast 1958: 158.
Lychnothamnus vectensis – Soulié-Märsche 1989: 160.
DISTRIBUTION. — Lychnothamnus vectensis has been recorded in the Hampshire (Reid & Groves 1921) and Paris (Riveline 1986) basins.In the Ebro Basin,this species occurs within Uppermost Priabonian-Lower Rupelian deposits in Santpedor, Rubió and Sarral (Tables 3, 4).
DESCRIPTION
Medium sized gyrogonite, variable in size, 580- 760 µm in high (mean 660 µm), and 480-620 µm in width (mean 560 µm), normally ellipsoidal but sometimes ovoidal in shape with an isopolarity index of 103-145 (mean 121). Spiral cells about 90 µm wide, normally flat to convex. Seven to nine (frequently eight), convolutions are visible laterally. Apex flat or slightly convex. Spiral cells do not show constrictions in the apical periphery but display marked thinning in the apical zone, resulting in an apical to periapical depression. In some gyrogonites, the apex is ornamented by tubercles that vary notably in size depending on the specimen. Ŋe base is rounded with a large and superficial basal pore about 70 µm across.
REMARKS
Chara vectensis was first determined by Groves (1926) based on ellipsoidal gyrogonites extremely variable in size, 800-1000 µm in high and 500- 800 µm in width, with 9-10 concave spiral cells usually swollen at the apex and often forming prominent rosettes. Ŋe holotype designated and illustrated by Groves (1926), from the A’Court Smith collection at the Natural History Museum, London, belonged precisely to the few specimens which displayed a prominent apical rosette and this character was further considered as diagnostic of the species, rather than as merely an extreme version of its total morphological variation. Taking into account this range of variation, the main difference between the material from the Ebro Basin and the type material is the size of the gyrogonites, which are about 200 µm smaller in the Ebro Basin. Gyrogonites of this species from the Paris Basin gathered in the collection created by J. Riveline (Laboratoire de Biominéralization et énvironnement sedimentaires, Université Pierre et Marie Curie, Paris) show biometric parameters (mean values of 715 µm high, 595 µm wide, isopolarity index of 115 and 8 convolutions) similar to the type material. Furthermore, most of the gyrogonites from the Paris Basin show a swollen apex and concave spiral cells whilst the presence of prominent apical nodules is not common.
description: Published as part of Sanjuan, Josep & Martín-Closas, Carles, 2014, Taxonomy and palaeobiogeography of charophytes from the Upper Eocene- Lower Oligocene of the Eastern Ebro Basin (Catalonia, NE Spain), pp. 385-420 in Geodiversitas 36 (3) on page 404, DOI: 10.5252/g2014n3a3, http://zenodo.org/record/4538531
Polynomial (chaos) approximation of maximum eigenvalue functions: efficiency and limitations
Creators: name: Fenzi, Luca
name: Michiels, Wim
Publisher: name: arXiv
Year: 2018
Subjects: subject: Numerical Analysis (math.NA)
subject: Dynamical Systems (math.DS)
subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 41A10 (Primary) 65F15, 65D05, 65D32 (Secondary)

description: This paper is concerned with polynomial approximations of the spectral abscissa function (the supremum of the real parts of the eigenvalues) of a parameterized eigenvalue problem, which are closely related to polynomial chaos approximations if the parameters correspond to realizations of random variables. Unlike in existing works, we highlight the major role of the smoothness properties of the spectral abscissa function. Even if the matrices of the eigenvalue problem are analytic functions of the parameters, the spectral abscissa function may not be everywhere differentiable, even not everywhere Lipschitz continuous, which is related to multiple rightmost eigenvalues or rightmost eigenvalues with multiplicity higher than one. The presented analysis demonstrates that the smoothness properties heavily affect the approximation errors of the Galerkin and collocation-based polynomial approximations, and the numerical errors of the evaluation of coefficients with integration methods. A documentation of the experiments, conducted on the benchmark problems through the software Chebfun, is publicly available.
description: This is a pre-print of an article published in Numerical Algorithms. The final authenticated version is available online at: https://doi.org/10.1007/s11075-018-00648-9
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0822
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0822, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0822, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Magnetization switching in the inertial regime
Creators: name: Neeraj, Kumar
name: Pancaldi, Matteo
name: Scalera, Valentino
name: Perna, Salvatore
name: d'Aquino, Massimiliano
name: Serpico, Claudio
name: Bonetti, Stefano
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have numerically solved the Landau-Lifshitz-Gilbert (LLG) equation in its standard and inertial forms to study the magnetization switching dynamics in a $3d$ thin film ferromagnet. The dynamics is triggered by ultrashort magnetic field pulses of varying width and amplitude in the picosecond and Tesla range. We have compared the solutions of the two equations in terms of switching characteristic, speed and energy analysis. Both equations return qualitatively similar switching dynamics, characterized by regions of slower precessional behavior and faster ballistic motion. In case of inertial dynamics, ballistic switching is found in a 25 % wider region in the parameter space given by the magnetic field amplitude and width. The energy analysis of the dynamics is qualitatively different for the standard and inertial LLG equations. In the latter case, an extra energy channel, interpreted as the kinetic energy of the system, is available. Such extra channel is responsible for a resonant energy absorption at THz frequencies, consistent with the occurence of spin nutation.
description: 9 pages, 6 figures
Hydrodynamic Limit for an Anharmonic Chain under Boundary Tension
Creators: name: Marchesani, Stefano
name: Olla, Stefano
Publisher: name: arXiv
Year: 2018
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 82C05, 35L65

description: We study the hydrodynamic limit for the isothermal dynamics of an anharmonic chain under hyperbolic space-time scaling under varying tension. The temperature is kept constant by a contact with a heat bath, realised via a stochastic momentum-preserving noise added to the dynamics. The noise is designed to be large at the microscopic level, but vanishing in the macroscopic scale. Boundary conditions are also considered: one end of the chain is kept fixed, while a time-varying tension is applied to the other end. We show that the volume stretch and momentum converge (in an appropriate sense) to a weak solution of a system of hyperbolic conservation laws (isothermal Euler equations in Lagrangian coordinates) with boundary conditions. This result includes the shock regime of the system. This is proven by adapting the theory of compensated compactness to a stochastic setting, as developed by J. Fritz in \cite{Fritz1} for thesame model without boundary conditions. Finally, changing the external tension allows us to define thermodynamic isothermal transformations between equilibrium states. We use this to deduce the first and the second principle of Thermodynamics for our model.
Additional file 1 of Social support and mental well-being among people with and without chronic illness during the Covid-19 pandemic: evidence from the longitudinal UCL covid survey
Creators: name: Aksoy, Ozan
name: Wu, Alison Fang-Wei
name: Aksoy, Sevgi
name: Rivas, Carol
Publisher: name: figshare
Year: 2024
Subjects: Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Supplementary Material 1
Grappling with complexity: Medical students’ reflective writings about challenging patient encounters as a window into professional identity formation
Creators: name: Wald, Hedy S.
name: White, Jordan
name: Reis, Shmuel P.
name: Esquibel, Angela Y.
name: Anthony, David
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Aim: Clerkship-specific interactive reflective writing (IRW)-enhanced reflection may enhance professional identity formation (PIF), a fundamental goal of medical education. PIF process as revealed in students? reflective writing (RW) has been understudied. Methods: The authors developed an IRW curriculum within a Family Medicine Clerkship (FMC) and analyzed students? reflections about challenging/difficult patient encounters using immersion-crystallization qualitative analysis. Results: The qualitative analysis identified 26 unique emergent themes and five distinct thematic categories (1. Role of emotions, 2. Role of cognition, 3. Behaviorally responding to situational context, 4. Patient factors, and 5. External factors) as well as an emergent PIF model from a directed content analysis. The model describes students? backgrounds, emotions and previous experiences in medicine merging with external factors and processed during student?patient interactions. The RWs also revealed that processing often involves polarities (e.g. empathy/lack of empathy or encouragement/disillusionment) as well as dissonance between idealized visions and lived reality. Conclusions: IRW facilitates and ideally supports grappling with the lived reality of medicine; uncovering a “positive hidden curriculum” within medical education. The authors propose engaging learners in guided critical reflection about complex experiences for meaning-making within a safe learning climate as a valuable way to cultivate reflective, resilient professionals with “prepared” minds and hearts for inevitable challenges of healthcare practice.
JAMIYATDA XOTIN-QIZLARNING BANDLIGINI TA'MINLASHDA DAVLAT SIYOSATINING ROLI
Creators: name: Yusupova, Nigora
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada mamlakatimizda oila va xotin-qizlarni qo‘llab-quvvatlash borasida qabul qilingan me’yoriy-huquqiy hujjatlarda belgilab berilgan ustuvor vazifalar, xususan, xotin-qizlarning huquq va qonuniy manfaatlarini himoya qilish, ularning iqtisodiy, ijtimoiy va siyosiy faolligini oshirish, sog‘lig‘ini saqlash, kasbga o‘qitish va bandligini ta’minlash, tadbirkorlikka keng jalb etish, ehtiyojmand xotin-qizlarni ijtimoiy qo‘llab-quvvatlash, gender tenglikni ta’minlash borasida muhim islohotlar va ularning ahamiyati yoritib beriladi.
Lychnothamnus major
Creators: name: Sanjuan, Josep
name: Martín-Closas, Carles
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Plantae
Charophyta
Charophyceae
Charales
Characeae
Lychnothamnus
Lychnothamnus major

description: Lychnothamnus major(Grambast & Paul, 1965)
Soulié-Märsche, 1989
(Fig. 8 H-K)
Rhabdochara major Grambast & Paul, 1965: 241, 242, pl. 2, figs 1-4.
Lychnothamnus major – Soulié-Märsche 1989: 159.
DISTRIBUTION. — Lychnothamnus major has hitherto been recorded from numerous European sites of various ages within the Rupelian. In France, this species occurs in the Paris (Grambast & Paul 1965; Riveline 1986), Aquitaine (Feist & Ringeade 1977), Provence (Feist-Castel 1977a) and Languedoc (Grambast 1962) basins. In Germany, this species has been documented by Feist-Castel (1977a) and Schwarz (1985). Moreover, Kissling (1974) reported this species in the western sector of the Swiss Molasse and Baciu and Feist (1999) from north-western Romania. In Spain, it has already been described from some localities of the Ebro Basin by Choi (1989) and we found it in Sarral and El Talladell (Table 4).
DESCRIPTION
Gyrogonites very large, 780-1000 µm high (mean 900 µm) and 680-840 µm wide (mean 780 µm), ellipsoidal in shape with an isopolarity index ranging from 105-128, (average 117). Spiral cells in the apical zone show a remarkably constant width, which results in a flat apex. Ŋe base is tapered with a star-shaped basal pore, about 180 µm in diameter. Eight to nine (frequently eight) cells visible laterally. Ŋese are normally concave, about 118 µm in width, non-ornamented and separated by prominent sutures which in some specimens are bicarinate.
REMARK
Many authors have reported that transitional morphotypes occur between L. stockmansi and L. major (Feist-Castel 1977a; Baciu & Feist 1999).
description: Published as part of Sanjuan, Josep & Martín-Closas, Carles, 2014, Taxonomy and palaeobiogeography of charophytes from the Upper Eocene- Lower Oligocene of the Eastern Ebro Basin (Catalonia, NE Spain), pp. 385-420 in Geodiversitas 36 (3) on pages 404-406, DOI: 10.5252/g2014n3a3, http://zenodo.org/record/4538531
The Relevance of the Dipole Penguin Operators in $ε'/ε$
Creators: name: Bertolini, S.
name: Fabbrichesi, M.
name: Gabrielli, E.
Publisher: name: arXiv
Year: 1993
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The standard model contribution to $ε'/ε$ of the magnetic- and electric-dipole penguin operators $Q_{11} = \frac{g_s}{16π^2} \, m_s \: \bar{s}\, σ_{μν} t^a G^{μν}_a (1-γ_5 )\, d $ and $Q_{12} = \frac{eQ_d}{16π^2}\, m_s \: \bar{s}\, σ_{μν} F^{μν} (1-γ_5 )\, d $ is discussed. While the electromagnetic penguin $Q_{12}$ seems to have a vanishingly small matrix element, we find that the gluonic dipole operator $Q_{11}$ may give a contribution to $ε'/ε$ comparable to that of other operators so far considered, and should therefore be consistently included in the analysis.
description: 14 pages, LATEX, CERN-TH.7097/93 and SISSA 174/93/EP, (alternative evaluation of the hadronic matrix element and new tables)
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0715
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0715, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0715, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Classification of handwritten drawings of people with Parkinson's disease by using histograms of oriented gradients and the random forest classifier
Creators: name: Folador, João Paulo
name: Rosebrock, Adrian
name: Pereira, Adriano Alves
name: Vieira, Marcus Fraga
name: Andrade, Adriano Oliveira
Publisher: name: Zenodo
Year: 2019
Subjects: Parkinson's disease
Tremor
Handwritten drawing classification
Random forest classifier
Histograms of oriented gradients

description: Parkinson’s disease (PD) is a neurological disorder that is progressive and causes losses of dopaminergic neurons from the substantia nigra, a region in the human brain. The decrease of dopamine in this area elucidates the presence of motor symptoms, such as tremors, bradykinesia, rigidity, gait impairment, and non-motor symptoms, e.g., depression, loss of cognitive functions, sleep problems, and nerve pain. Among the motor symptoms, tremors can have the most impact on the social activities of people with PD. Furthermore, there is difficulty in diagnosing the underlying disorder that causes tremors. Thus, the study and development of methods to assess tremors and their severity is of paramount relevance for clinical practice. A typical clinical tool to evaluate tremor severity is the analysis of hand drawing shapes (e.g., spirals, circles, meanders, waves). The evaluation of these drawings is dependent on the experience of professionals, yielding a high variability of results. Aiming to contribute to the objective evaluation of hand drawing shapes of people with PD, this research proposes the application of the Random Forest Classifier to classify Histograms of Oriented Gradients (HOG) estimated from sinusoidal patterns collected from healthy individuals (n=12) and from people with PD (n=15). The highest accuracy, sensitivity and specificity classification success rates were of 83%, 85% and 81%, respectively. These results can be relevant for the early detection of pathological tremors, the follow-up of medical treatments and the diagnosis of parkinsonian conditions.
Multimagnon dynamics and thermalization in the $S=1$ easy-axis ferromagnetic chain
Creators: name: Sharma, Prakash
name: Lee, Kyungmin
name: Changlani, Hitesh J.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Quasiparticles are physically motivated mathematical constructs for simplifying the seemingly complicated many-body description of solids. A complete understanding of their dynamics and the nature of the effective interactions between them provides rich information on real material properties at the microscopic level. In this work, we explore the dynamics and interactions of magnon quasiparticles in a ferromagnetic spin-1 Heisenberg chain with easy-axis onsite anisotropy, a model relevant for the explanation of recent terahertz optics experiments on NiNb$_2$O$_6$ [P. Chauhan et al., Phys. Rev. Lett. 124, 037203 (2020)],and nonequilibrium dynamics in ultracold atomic settings [W.C. Chung et al., Phys. Rev. Lett. 126, 163203 (2021)]. We build a picture for the properties of clouds of a few magnons with the help of exact diagonalization and density matrix renormalization group calculations supported by physically motivated Jastrow wavefunctions. We show how the binding energy of magnons effectively reduces with their number and explain how this energy scale is of direct relevance for dynamical magnetic susceptibility measurements. This understanding is used to make predictions for ultracold-atomic platforms which are ideally suited to study the thermalization of multimagnon states. We simulate the nonequilibrium dynamics of these chains using the matrix product state based time-evolution block decimation algorithm and explore the dependence of revivals and thermalization on magnon density and easy-axis onsite anisotropy (which controls the strength of effective magnon interactions). We observe behaviors akin to those reported for many-body quantum scars which we explain with an analytic approximation that is accurate in the limit of small anisotropy.
description: 18 pages, 10 figures. Typos fixed, references added, and referee comments addressed in v2. v2 closely matches the published version
Implementation, Compilation, Optimization of Object-Oriented Languages, Programs and Systems - Report on the Workshop ICOOOLPS'2006 at ECOOP'06
Creators: name: Ducournau, Roland
name: Gagnon, Etienne
name: Krintz, Chandra
name: Mulet, Philippe
name: Vitek, Jan
name: Zendra, Olivier
Publisher: name: arXiv
Year: 2007
Subjects: subject: Performance (cs.PF)
subject: Programming Languages (cs.PL)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: ICOOOLPS'2006 was the first edition of ECOOP-ICOOOLPS workshop. It intended to bring researchers and practitioners both from academia and industry together, with a spirit of openness, to try and identify and begin to address the numerous and very varied issues of optimization. This succeeded, as can be seen from the papers, the attendance and the liveliness of the discussions that took place during and after the workshop, not to mention a few new cooperations or postdoctoral contracts. The 22 talented people from different groups who participated were unanimous to appreciate this first edition and recommend that ICOOOLPS be continued next year. A community is thus beginning to form, and should be reinforced by a second edition next year, with all the improvements this first edition made emerge.
description: The original publication is available at http://www.springerlink.com
Diffusing Up the Hill: Dynamics and Equipartition in Highly Unstable Systems
Creators: name: Šiler, Martin
name: Ornigotti, Luca
name: Brzobohatý, Oto
name: Jákl, Petr
name: Ryabov, Artem
name: Holubec, Viktor
name: Zemánek, Pavel
name: Filip, Radim
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Stochastic motion of particles in a highly unstable potential generates a number of diverging trajectories leading to undefined statistical moments of the particle position. This makes experiments challenging and breaks down a standard statistical analysis of unstable mechanical processes and their applications. A newly proposed approach takes advantage of the local characteristics of the most probable particle motion instead of the divergent averages. We experimentally verify its theoretical predictions for a Brownian particle moving near an inflection in a highly unstable cubic optical potential. The most-likely position of the particle atypically shifts against the force despite the trajectories diverge in the opposite direction. The local uncertainty around the most-likely position saturates even for strong diffusion and enables well-resolved position detection. Remarkably, the measured particle distribution quickly converges to the quasi-stationary one with the same atypical shift for different initial particle positions. The demonstrated experimental confirmation of the theoretical predictions approves the utility of local characteristics for highly unstable systems which can be exploited in thermodynamic processes to uncover energetics of unstable systems.
description: SM as ancillary file
Additional file 1 of Optimizing the Maastricht Work-Related Support intervention in clinical patient care: the value of integrating action research into intervention mapping
Creators: name: Butink, Maarten
name: Hooper, Shari
name: Boonen, Annelies
name: Baadjou, Vera
name: Boymans, Tim
name: Pierik, Marieke
name: de Rijk, Angelique
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified

description: Supplementary Material 1: Interview guide to collect experiences on providing Maastricht Work-Related Support (WRS) in clinical care
Are we SHARP enough? The importance of adequate patient selection in sorafenib treatment for hepatocellular carcinoma
Creators: name: Labeur, Tim A.
name: Cate, David W. G. Ten
name: R. Bart Takkenberg
name: Azahaf, Hicham
name: Oijen, Martijn G. H. Van
name: Delden, Otto M. Van
name: Man, Robert A. De
name: Vugt, Jeroen L. A. Van
name: IJzermans, Jan N. M.
name: Eskens, Ferry A. L. M.
name: Heinz-Josef Klümpen
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Background: Upon FDA/EMEA registration for hepatocellular carcinoma (HCC), sorafenib received a broader therapeutic indication than the eligibility criteria of the landmark SHARP trial. This allowed treatment of SHARP non-eligible patients in daily clinical practice. Aim: To assess sorafenib efficacy and safety in SHARP eligible and non-eligible patients, and determine the validity of the current therapeutic indication as described by the FDA/EMEA. Patients and methods: Consecutive patients treated with sorafenib for advanced HCC at two Dutch tertiary referral centers between 2007 and 2016 were analyzed retrospectively. Primary outcome was overall survival (OS). Secondary outcomes were time to progression (TTP), response rate, adverse events and reasons for discontinuation. Outcomes were compared between SHARP eligible and non-eligible patients. Results: One hundred and ninety-three of 257 (75%) patients were SHARP eligible. SHARP eligible patients (9.5 months, 95% CI 7.7–11.3) had a longer median OS than non-eligible patients (5.4 months, 95% CI 3.6–7.1) (log-rank p p Conclusions: Landmark trial outcomes of sorafenib for HCC are reproducible in daily practice, provided that the SHARP eligibility criteria are respected. Based on the findings of this and previous studies, sorafenib usage should be restricted to Child–Pugh A patients.
A Comprehensive Consistency Check between Synchrotron radiation and the Observed Gamma-ray Burst Spectra
Creators: name: Wang, Dao-Zhou
name: Zhao, Xiao-Hong
name: Zhang, Zhao
name: Zhang, Bin-Bin
name: Peng, Zhao-Yang
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We performed a time-resolved spectral analysis of 53 bright gamma-ray bursts (GRBs) observed by \textit{Fermi}/GBM. Our sample consists of 908 individual spectra extracted from the finest time slices in each GRB. We fitted them with the synchrotron radiation model by considering the electron distributions in five different cases: mono-energetic, single power-law, Maxwellian, traditional fast cooling, and broken power-law. Our results were further qualified through Bayesian Information Criterion (BIC) by comparing with the fit by empirical models, namely the so-called Band function and cut-off power-law models. Our study showed that the synchrotron models, except for the fast-cooling case, can successfully fit most observed spectra, with the single power-law case being the most preferred. We also found that the electron distribution indices for the single power-law synchrotron fit in more than half of our spectra exhibits flux-tracking behavior, i.e., the index increases/decreases with the flux increasing/decreasing, implying that the distribution of the radiating electrons is increasingly narrower with time before the flux peaks and becomes more spreading afterward. Our results indicate that the synchrotron radiation is still feasible as a radiation mechanism of the GRB prompt emission phase.
description: 14 pages, 7 figures. Updated version accepted for publication in ApJ
Isgur-Wise Function from Bethe-Salpeter Amplitude
Creators: name: Kugo, Taichiro
name: Mitchard, Mark G.
name: Yoshida, Yuhsuke
Publisher: name: arXiv
Year: 1993
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We develop the improved ladder approximation to QCD in order to apply it to the heavy quark mesons. The resulting Bethe-Salpeter equation is expanded in powers of the inverse heavy quark mass 1/M, and is shown to be consistent with the heavy quark spin symmetry. We calculate numerically the universal leading order BS amplitude for heavy pseudoscalar and vector mesons, and use this to evaluate the Isgur-Wise function and the decay constant F_B. The resulting Isgur-Wise function predicts a large charge radius, rho^2 = 1.8 - 2.0, which when fitted to the ARGUS data corresponds to the value Vcb = .044 - .050 for the Kobayashi-Maskawa matrix element.
description: 26 pages, Plain TeX, 1 epsf and 6 PostScript files are included, KUNS 1234
Fixed points of circle actions on spaces with rational cohomology of $S^n V S^{2n} V S^{3n}$ or $P^2(n) V S^{3n}$
Creators: name: Singh, Mahender
Publisher: name: arXiv
Year: 2007
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55S17, 55R20

description: Let $X$ be a finitistic space with its rational cohomology isomorphic to that of the wedge sum $P^2(n)\vee S^{3n} $ or $S^{n} \vee S^{2n}\vee S^{3n}$. We study continuous $\mathbb{S}^1$ actions on $X$ and determine the possible fixed point sets up to rational cohomology depending on whether or not $X$ is totally non-homologous to zero in $X_{\mathbb{S}^1}$ in the Borel fibration $X\hookrightarrow X_{\mathbb{S}^1} \longrightarrow B_{\mathbb{S}^1}$. We also give examples realizing the possible cases.
description: 10 pages, appeared in Archiv der Mathematik
Studying the highly bent spectra of FR II-type radio galaxies with the KDA EXT model
Creators: name: Kuligowska, Elżbieta
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences
subject: 85-02

description: The KDA (Kaiser, Dennett-Thorpe & Alexander, 1997) EXT model, that is, the extension of the KDA model of FR (Faranoff & Riley) II-type source evolution, is applied and confronted with the observational data for selected FR II-type radio sources with significantly aged radio spectra. A sample of FR II-type radio galaxies with radio spectra strongly bent at their highest frequencies is used for testing the usefulness of the KDA EXT model.The dynamical evolution of FR II-type sources predicted with the KDA EXT model is briefly presented and discussed. The results are then compared to the ones obtained with the classical KDA approach, assuming the source's continuous injection and self-similarity. The results and corresponding diagrams obtained for the eight sample sources indicate that the KDA EXT model predicts the observed radio spectra significantly better than the best spectral fit provided by the original KDA model.
description: 13 pages, 8 figures