cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The burden of disease in early schizophrenia – a systematic literature review
Creators: name: Crespo-Facorro, Benedicto
name: Such, Pedro
name: Nylander, Anna-Greta
name: Madera, Jessica
name: Resemann, Henrike K.
name: Worthington, Emma
name: O’Connor, Mary-Ellen
name: Drane, Emma
name: Steeves, Sara
name: Newton, Richard
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Schizophrenia is a heterogeneous disorder with a burden that can vary greatly depending on the severity and the duration. Previous research has suggested that patients in the earlier stages of schizophrenia (typically first-episode schizophrenia) benefit from effective early treatment, however, a comprehensive review of the burden specifically in this population has not been undertaken. A systematic literature review was therefore conducted to characterize the clinical, economic, and humanistic burden, as reported in naturalistic studies of schizophrenia populations specifically at an early stage of disease in comparison with healthy controls, patients with chronic schizophrenia, and patients with other psychiatric disorders. Methods and Materials: Searches were conducted in MEDLINE, MEDLINE In-Process, Embase, PsycINFO, and EconLit databases for records published between January 2005 and April 2019, and of relevant conference abstracts published between January 2014 and May 2019. Data were extracted from relevant publications and subjected to qualitative evaluation. 52 publications were identified for inclusion and revealed a considerable burden for early schizophrenia with regards to mortality, psychiatric comorbidities such as substance abuse and depression, poor social functioning, and unemployment. Comparisons with chronic schizophrenia suggested a greater burden with longer disease duration, while comparisons with other psychiatric disorders were inconclusive. This review uncovered various gaps in the available literature, including limited or no data on incarcerations, caregiver burden, and costs associated with early schizophrenia. Overall, the burden of schizophrenia is apparent even in the early stages of the disease, although further research is required to quantify the burden with chronic schizophrenia and other psychiatric disorders.
Economic burden of treatment-resistant depression in privately insured US patients with co-occurring anxiety disorder and/or substance use disorder
Creators: name: Zhdanava, Maryia
name: Kuvadia, Harsh
name: Joshi, Kruti
name: Daly, Ella
name: Pilon, Dominic
name: Rossi, Carmine
name: Morrison, Laura
name: Lefebvre, Patrick
name: Nelson, Craig
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: To assess the burden of treatment-resistant depression (TRD) among privately insured patients with anxiety disorder and/or substance use disorders (SUD). Adults <65 years old were identified in the Optum Health Care Solutions Inc. database (July 2009–March 2017). Among those with major depressive disorder (MDD) and antidepressant use, patients who initiated a third antidepressant (index date) after two regimens at adequate dose and duration were classified in the TRD cohort and patients without evidence of TRD were classified in the non-TRD MDD control cohort. The non-MDD control cohort comprised patients without MDD. In the non-TRD MDD and non-MDD cohorts, the index date was imputed to mimic the distribution of time in the TRD cohort from the first antidepressant to the index date or from the start of eligibility to the index date, respectively. Patients with <6 months of continuous insurance eligibility pre-/post-index, psychosis, schizophrenia, bipolar disorder and related conditions, dementia, and development disorders, and/or no baseline anxiety disorder and/or SUD were excluded. Patients with TRD were matched 1:1 to patients with non-TRD MDD and patients without MDD, based on exact matching factors (i.e. availability of work loss data) and propensity scores computed based on characteristics measured pre-index. Outcomes, including healthcare resource use (HRU) and costs, work productivity loss and related costs measured per patient per year ≤24 months post-index were compared between matched TRD, non-TRD MDD and non-MDD cohorts. A total of 3166 patients were identified in the TRD cohort and matched to non-TRD MDD and non-MDD cohorts. Among patients with TRD (mean age 39 years, 60.5% female), 87.3% had an anxiety disorder, 24.1% had SUD. The TRD cohort had higher HRU vs non-TRD MDD and non-MDD cohorts: 0.32 vs 0.20 and 0.14 inpatient admissions, 0.91 vs 0.73 and 0.58 emergency department visits, and 23.8 vs 16.8 and 11.6 outpatient visits, respectively (all p p N = 310/cohort), patients with TRD had more work loss days (54) and higher work loss-related costs ($13,674) vs patients with non-TRD MDD (32 days; $7131) and without MDD (17 days; $4798; all p In patients with an anxiety disorder and/or SUD, TRD was associated with higher HRU, healthcare costs, work loss days and work loss-related costs.
Transforming approaches to treating TRK fusion cancer: historical comparison of larotrectinib and histology-specific therapies
Creators: name: Pollack, Megan
name: Keating, Karen
name: Wissinger, Erika
name: Jackson, Louis
name: Sarnes, Evelyn
name: Cuffel, Brian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The results from basket trials utilized to gain regulatory approval of tumor-agnostic therapies can be difficult to interpret without the context of a comparator arm. We describe the role and efficacy of histology-based treatments to provide a historical comparison with larotrectinib. A systematic literature review (SLR) was conducted on the clinical outcomes of current histology-based standard of care treatments used in non-small cell lung cancer, colorectal cancer, thyroid cancer, gliomas, soft tissue sarcoma, salivary gland cancer, and infantile fibrosarcoma (7 of the 21 tumor histologies in the larotrectinib trials). The review focused on advanced stage/metastatic disease to make a historical comparison with larotrectinib. Larotrectinib provides positive outcomes in both adult and pediatric patients with advanced or metastatic solid tumors known to harbor NTRK gene fusions across a wide range of tumor types. Although the numbers of patients per tumor type are limited, the results of this historical comparison demonstrated that larotrectinib is an efficacious treatment option when naïvely indirectly compared with historical treatments across all 7 reviewed tumor types, especially in comparison to later lines of therapy. Utilizing larotrectinib as a case example across these types of historical comparisons shows that larotrectinib provides positive efficacy outcomes in TRK fusion cancer across tumor histologies known to harbor NTRK gene fusions that may be preferable to historical treatments.
Patient perspectives on the use of half-unit insulin pens by people with type 1 diabetes: a cross-sectional observational study
Creators: name: Oliveira, Carolina Piras De
name: Mitchell, Beth D.
name: Ludi Fan
name: Garey, Colleen
name: Birong Liao
name: Jeoffrey Bispham
name: Vint, Nan
name: Perez-Nieves, Magaly
name: Hughes, Allyson
name: McAuliffe-Fogarty, Alicia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cardiology

description: Half-unit pens offer the ability to dose insulin more precisely. Information about half-unit pen use and evidence of their benefits and drawbacks is limited. This study aims to characterize people with type 1 diabetes (T1D) who have used (current/former = EVER) vs. those who have never used half-unit pens (NEVER users) and to understand their perspective. An observational cross-sectional online survey was administered through T1D Exchange’s online patient community, myGlu.org, to understand the use of half-unit insulin pens. The 278 adult participants (156 EVER, 122 NEVER) had a mean age of 41.8 ± 12.7 years, body mass index of 26.0 ± 3.8 kg/m2, glycated hemoglobin of 6.3% ± 1.0%, and 55% were male. EVER users had T1D for a shorter duration than NEVER users (p p p p N = 131) included prevention of hyperglycemia (40.5%), less anxiety or worry (23.7%), and prevention of hypoglycemia (16.8%). Half-unit insulin pen is perceived as an insulin device that may help people with T1D to avoid hypo- and hyperglycemic events and decrease their level of disease worry and anxiety. This study highlights the need for patients and health care providers to understand the benefits of half-unit pens while considering options for individualized diabetes management.
ОЦЕНКА ПОКАЗАТЕЛЕЙ АНАЛИЗА КОЖНОГО ПОКРОВА У ПАЦИЕНТОВ С ЭЛАСТОЗОМ КОЖИ
Creators: name: Алиев, А.Ш.
name: Хайдарова, Н.
name: Жандарбекова, Ш.
Publisher: name: Zenodo
Year: 2024

description: Изучения состояния кожи пациентов у пациентов с эластозом кожи на сегодняшний день считается одной из актуальных проблем в современной косметологии. Существует множество процедур и методов исследования для определения качества терапии по поводу эластоза кожи, однако не один из них не может полностью удовлетворить исследователя. В нашей статье мы предлагаем для изучения состояния кожи пациентов и оценки эффективности проведенной терапии использовать светодиодный анализатор кожи Mark Vu analizator. В исследованиях мы использовали анализ кожи по определению общего числа морщин, скрытых морщин, показатели фотостарения кожи.
Cost-utility analysis of second-line therapy with rituximab compared to tumour necrosis factor inhibitors in rheumatoid arthritis
Creators: name: Lopatina, Elena
name: Marshall, Deborah A.
name: Coupal, Louis
name: Le Lorier, Jacques
name: Choquette, Denis
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: To compare direct costs and treatment utility associated with the second-line therapy with rituximab and tumour necrosis factor inhibitors (TNFis) (adalimumab, etanercept, and infliximab) in patients with Rheumatoid Arthritis (RA) using data from a prospective registry. Health Assessment Questionnaire Disability Index (HAQ-DI) scores and RA-related healthcare resource utilization data (biologic agents and visits to rheumatologists) were extracted from a registry (Quebec, Canada) for patients with RA (n = 129) who had to discontinue a first-line TNFi and were treated with rituximab, adalimumab, etanercept, or infliximab as the second-line therapy between January 2007 and May 2016. A decision analytic model followed patients for 1 and 6 years. Treatment utility was measured as quality-adjusted life-years (QALYs) gained, which were calculated from HAQ-DI scores observed over the follow-up time. Quebec 2020 unit costs (Canadian Dollars, $) were used to value healthcare resource consumption. A probabilistic sensitivity analysis was performed with 10,000 Monte Carlo simulations to assess uncertainty around point-estimates of cost-utility. Over 1-year, rituximab and etanercept resulted in the effectiveness of 0.80 QALYs gained at the cost of $14,291and $18,880, respectively, and were dominant (i.e., associated with lower costs and more QALYs gained) compared to adalimumab (0.79 QALYs, $18,825) and infliximab (0.76 QALYs, $20,158). Over 6-years, rituximab (4.42 QALYs, $82,402) was dominant compared to adalimumab (4.30 QALYs, $101,420), etanercept (4.02 QALYs, $99,191), and infliximab (3.71 QALYs, $100,396). In the probabilistic analysis, rituximab was dominant over adalimumab, etanercept, and infliximab with the probability of 0.51, 0.62, and 0.65, respectively. Real-world data revealed differences between alternative biologic agents used as the second-line therapy in terms of both treatment costs for the healthcare system and utility of treatment for patients. Therefore, new guidelines on the order of selecting and switching biologic agents should be explored.
Essential oil composition, free radical scavenging activity and polyphenolic content of Gaillonia eriantha Jaub. & Spach from Iran
Creators: name: Atefeh Bahmanzadegan
name: Rowshan, Vahid
name: Faraneh Zareiyan
name: Hatami, Ahmad
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Plant Biology

description: Gaillonia eriantha is a member of family Paederieae (Rubiaceae). The essential oil of G. eriantha growing wild in south of Iran was obtained by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Antioxidante activity and polyphenolic content were identified by DPPH microplate method and HPLC-DAD, respectively. Twenty-two compounds were identified in the oil. The major volatile compounds were camphor (14.8%), octyl formate (14.7%), 1,8-cineole (10.9%), n-decane (8.1%), n-undecane (6.8%), n-dodecane (6.1%), n-nonane(5.4%) and α-agarofuran (5.2%). The antioxidant activity of the extract of G. eriantha was found to be 786.57 μg/mL. It was found that the predominant phenolic constituents were chlorogenic acid (2.23 mg/g), catechin (0.37 mg/g), hesperidin (0.13 mg/g), trans-ferulic acid (0.12 mg/g), caffeic acid (0.051 mg/g), carvacrol (0.028 mg/g) and vanillin (0.021 mg/g), respectively.
Costs of COVID-19 pandemic associated with diabetes in Europe: a health care cost model
Creators: name: Bain, Stephen C.
name: Czernichow, Sebastien
name: Bøgelund, Mette
name: Madsen, Maria Elmegaard
name: Yssing, Cecilie
name: McMillan, Annabell Cajus
name: Hvid, Christian
name: Hettiarachchige, Nadilka
name: Panton, Ulrik Haagen
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 60506 Virology

description: Diabetes is associated with progression to severe COVID-19. The objective of this study was to estimate to what extent the increased risk among people with diabetes could impact the secondary care costs of COVID-19 throughout Europe during the first wave of the COVID-19 pandemic from January to June 2020. Applying a health care cost model based on inputs from data published in international peer-reviewed journals, identified via a rapid literature review this study aimed to estimate the total secondary sector costs of COVID-19. Estimates of unit costs were based on data from Denmark, France, Spain and the UK. We calculated average costs per patient without diabetes and according to four diabetes categories based on risk of hospitalization, admission to intensive care unit, ventilator support and length of hospital stay. The estimated cost per hospital admission during the first wave of COVID-19 in Europe ranged between EUR 25,018 among people with type 2 diabetes in good glycaemic control to EUR 57,244 among people with type 1 diabetes in poor glycaemic control, reflecting higher risk of intensive care, ventilator support and longer hospital stay according to diabetes category, while the corresponding cost for people without diabetes was estimated at EUR 16,993. The total direct costs of secondary care of COVID-19 in Europe were estimated at EUR 13.9 billion. Thus, 23.5% of the total costs accounted for treating people with diabetes. This study highlights the importance of a greater focus on prevention and adequate treatment of diabetes and the need for special attention to avoid infection with COVID-19 to the extent possible among those already diagnosed with diabetes.
Patient perspectives on the use of half-unit insulin pens by people with type 1 diabetes: a cross-sectional observational study
Creators: name: de Oliveira, Carolina Piras
name: Mitchell, Beth D.
name: Fan, Ludi
name: Garey, Colleen
name: Liao, Birong
name: Bispham, Jeoffrey
name: Vint, Nan
name: Perez-Nieves, Magaly
name: Hughes, Allyson
name: McAuliffe-Fogarty, Alicia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cardiology

description: Half-unit pens offer the ability to dose insulin more precisely. Information about half-unit pen use and evidence of their benefits and drawbacks is limited. This study aims to characterize people with type 1 diabetes (T1D) who have used (current/former = EVER) vs. those who have never used half-unit pens (NEVER users) and to understand their perspective. An observational cross-sectional online survey was administered through T1D Exchange’s online patient community, myGlu.org, to understand the use of half-unit insulin pens. The 278 adult participants (156 EVER, 122 NEVER) had a mean age of 41.8 ± 12.7 years, body mass index of 26.0 ± 3.8 kg/m2, glycated hemoglobin of 6.3% ± 1.0%, and 55% were male. EVER users had T1D for a shorter duration than NEVER users (p p p p N = 131) included prevention of hyperglycemia (40.5%), less anxiety or worry (23.7%), and prevention of hypoglycemia (16.8%). Half-unit insulin pen is perceived as an insulin device that may help people with T1D to avoid hypo- and hyperglycemic events and decrease their level of disease worry and anxiety. This study highlights the need for patients and health care providers to understand the benefits of half-unit pens while considering options for individualized diabetes management.
Transforming approaches to treating TRK fusion cancer: historical comparison of Larotrectinib and histology-specific therapies
Creators: name: Pollack, Megan
name: Keating, Karen
name: Wissinger, Erika
name: Jackson, Louis
name: Sarnes, Evelyn
name: Cuffel, Brian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The results from basket trials utilized to gain regulatory approval of tumor-agnostic therapies can be difficult to interpret without the context of a comparator arm. We describe the role and efficacy of histology-based treatments to provide a historical comparison with larotrectinib. A systematic literature review (SLR) was conducted on the clinical outcomes of current histology-based standard of care treatments used in non-small cell lung cancer, colorectal cancer, thyroid cancer, gliomas, soft tissue sarcoma, salivary gland cancer, and infantile fibrosarcoma (6 of the 21 tumor histologies in the larotrectinib trials). The review focused on advanced stage/metastatic disease to make a historical comparison with larotrectinib. Larotrectinib provides positive outcomes in both adult and pediatric patients with advanced or metastatic solid tumors known to harbor NTRK gene fusions across a wide range of tumor types. Although the numbers of patients per tumor type are limited, the results of this historical comparison demonstrated that larotrectinib is an efficacious treatment option when naïvely indirectly compared with historical treatments across all 6 reviewed tumor types, especially in comparison to later lines of therapy. Utilizing larotrectinib as a case example across these types of historical comparisons shows that larotrectinib provides positive efficacy outcomes in TRK fusion cancer across tumor histologies known to harbor NTRK gene fusions that may be preferable to historical treatments.
Novel propanamide analogue and antiproliferative diketopiperazines from mangrove Streptomyces sp. Q24
Creators: name: Xuewei Ye
name: Weiyun Chai
name: Lian, Xiao-Yuan
name: Zhizhen Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A new propanamide analogue (1), along with one known alkaloid (2) and four known diketopiperazines (3–6), was isolated from a cultured broth of the actinomycete Streptomyces sp. Q24 that was obtained from a sample of mangrove soil. The structures of these isolates were characterised as 3-acetylamino-N-2-thienyl-propanamide (1), N-acetyltryptamine (2), cyclo-(l-phenylalanine-l-4-hydroxyproline) (3), cyclo-(l-leucine-l-4-hydroxyproline) (4), cyclo-(l-phenylalanine-d-4-hydroxyproline) (5) and cyclo-(l-leucine-l-proline) (6) based on their NMR and HRESIMS data as well as optical rotation. Three diketopiperazines (3, 4, 6) showed activity in inhibiting the proliferation of human glioma U87-MG and U251 cells. This type of the new propanamide analogue (1) is first found from a nature source and the antiproliferative property of these three diketopiperazines against glioma cells is also reported herein for the first time.
Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii
Creators: name: Jean-Bosco Jouda
name: Judith-Laure Demgne Fopossi
name: Kengne, Francine Mediesse
name: Mbazoa, Céline Djama
name: Golz, Christopher
name: Strohmann, Carsten
name: Fogue, Simeon Kouam
name: Wandji, Jean
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment. The new compounds were screened for their cytotoxic and antibacterial properties; however, the tested compounds displayed no significant activities.
title: OFROM: interview avec unine11b02m
Creators: name: Delafontaine, François
name: Barras, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.3f60h4vw.v2#daedd3a1183d42b2f395062d311d1f7785c7d38a
Costs of COVID-19 pandemic associated with diabetes in Europe: a health care cost model
Creators: name: Bain, Stephen C.
name: Czernichow, Sebastien
name: Bøgelund, Mette
name: Madsen, Maria Elmegaard
name: Yssing, Cecilie
name: McMillan, Annabell Cajus
name: Hvid, Christian
name: Hettiarachchige, Nadilka
name: Panton, Ulrik Haagen
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 60506 Virology

description: Diabetes is associated with progression to severe COVID-19. The objective of this study was to estimate to what extent the increased risk among people with diabetes could impact the secondary care costs of COVID-19 throughout Europe during the first wave of the COVID-19 pandemic from January to June 2020. Applying a health care cost model based on inputs from data published in international peer-reviewed journals, identified via a rapid literature review this study aimed to estimate the total secondary sector costs of COVID-19. Estimates of unit costs were based on data from Denmark, France, Spain and the UK. We calculated average costs per patient without diabetes and according to four diabetes categories based on risk of hospitalisation, admission to intensive care unit, ventilator support and length of hospital stay. The estimated cost per hospital admission during the first wave of COVID-19 in Europe ranged between EUR 25,018 among people with type 2 diabetes in good glycaemic control to EUR 57,244 among people with type 1 diabetes in poor glycaemic control, reflecting higher risk of intensive care, ventilator support and longer hospital stay according to diabetes category, while the corresponding cost for people without diabetes was estimated at EUR 16,993. The total direct costs of secondary care of COVID-19 in Europe were estimated at EUR 13.9 billion. Thus, 23.5% of the total costs accounted for treating people with diabetes. This study highlights the importance of a greater focus on prevention and adequate treatment of diabetes and the need for special attention to avoid infection with COVID-19 to the extent possible among those already diagnosed with diabetes.
Antifungal metabolites from Schinopsis balansae Engl (Anacardiaceae): isolation, identification and evidences of their mode of action on Fusarium graminearum Schwabe
Creators: name: Ficoseco, María Eugenia Aristimuño
name: Sequin, Christian Javier
name: Aceñolaza, Pablo Gilberto
name: Vattuone, Marta Amelia
name: Catalán, Cesar Atilio N.
name: Sampietro, Diego Alejandro
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: An antifungal activity-directed fractionation of leaf constituents from Schinopsis balansae on Fusarium graminearum yielded a fraction mainly made of a mixture of four 3-n-heptadec(en)ylcatechols (PALK). The PALK fraction showed on macroconidia germination a MIC100 value of 500 μg/mL which was twofold higher than that required for prothioconazole (MIC100 = 250 μg/mL). Sublethal concentrations of PALK modify the morphogenesis in germinating macroconidia, and decreased fungal production of H2O2 and deoxynivalenol biosynthesis at early fungal growth. Mixes of PALK and prothioconazole showed a synergic interaction. Our findings suggest that PALK constituents might restrict the adherence of F. graminearum to the surface of its hosts and its virulence on susceptible cereals. They deserve further research as additives of azole fungicides against F. graminearum.
Economic burden of treatment-resistant depression in privately insured US patients with co-occurring anxiety disorder and/or substance use disorder
Creators: name: Zhdanava, Maryia
name: Kuvadia, Harsh
name: Joshi, Kruti
name: Daly, Ella
name: Pilon, Dominic
name: Rossi, Carmine
name: Morrison, Laura
name: Lefebvre, Patrick
name: Nelson, Craig
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: To assess the burden of treatment-resistant depression (TRD) among privately-insured patients with anxiety disorder and/or substance use disorders (SUD). Adults <65 years old were identified in the OptumHealth Care Solutions, Inc. database (07/2009-03/2017). Among those with major depressive disorder (MDD) and antidepressant use, patients who initiated a third antidepressant (index date) after two regimens at adequate dose and duration were classified in the TRD cohort and patients without evidence of TRD were classified in the non-TRD MDD control cohort. The non-MDD control cohort comprised of patients without MDD. In the non-TRD MDD and non-MDD cohorts, the index date was imputed to mimic the distribution of time in the TRD cohort from the first antidepressant to the index date or from the start of eligibility to the index date, respectively. Patients with <6 months of continuous insurance eligibility pre-/post-index, psychosis, schizophrenia, bipolar disorder and related conditions, dementia, and development disorders, and/or no baseline anxiety disorder and/or SUD were excluded. Patients with TRD were matched 1:1 to patients with non-TRD MDD and patients without MDD, based on exact matching factors (i.e., availability of work loss data) and propensity scores computed based on characteristics measured pre-index. Outcomes, including healthcare resource use (HRU) and costs, work productivity loss and related costs measured per-patient-per-year ≤24 months post-index were compared between matched TRD, non-TRD MDD and non-MDD cohorts. A total of 3,166 patients were identified in the TRD cohort and matched to non-TRD MDD and non-MDD cohorts. Among patients with TRD (mean age 39 years, 60.5% female), 87.3% had an anxiety disorder, 24.1% had SUD. The TRD cohort had higher HRU vs non-TRD MDD and non-MDD cohorts: 0.32 vs 0.20 and 0.14 inpatient admissions, 0.91 vs 0.73 and 0.58 emergency department visits, and 23.8 vs 16.8 and 11.6 outpatient visits, respectively (all p In patients with an anxiety disorder and/or SUD, TRD was associated with higher HRU, healthcare costs, work loss days and work loss-related costs.
title: The Effect of Internal vs. External Attributions and Level of Information on Perceptions and Concessions in a Conflict Situation
Creators: name: Docalovich, William Walter
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1988

description: This study investigated predicted concessions and subject impressions of internally vs. externally motivated opponents in a conflict situation. One hundred and twenty undergraduate subjects read brief scenarios that presented opening statements made by opponents in a negotiation involving the division of excess funds in an organization. The opponent asked for 80% of the excess money and either blamed external or internal reasons for not conciliating. Half the subjects were also presented with additional information regarding the opponent's prior behavior along the dimensions of consistency, consensus and distinctiveness. It was hypothesized that attribution would interact with additional information so that external additional information opponents would receive higher concessions and more favorable impressions. The results do not support this hypothesis. Results indicate that external opponents received higher concessions (p<.0001); and more favorable impressions (likeableness, p<.0001; reasonableness, p<.0001; trustworthiness, p<.0001). The results are discussed in relation to the possible redundancy of the variable information with attributions. Discussion also centers on previous published studies (Baron, 1985; Rubin et al.; 1980) that hypothesized a similar pattern of results as found in this study. Each previous study obtained opposite results of those found in this study.
Two 2-dimensional cadmium(II) coordination polymers with 3-amino-5-methylthio-1,2,4-triazolate ligand
Creators: name: Yun-Jian Li
name: Wang, Yu-Ling
name: Xu, Wen-Yuan
name: Han, Chang-Bao
name: Liu, Qing-Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Plant Biology
subject: Computational Biology

description: Reactions of cadmium(II) salts with 3-amino-5-methylthio-1H-1,2,4-triazole (Hamstz) afforded two cadmium(II) coordination polymers, [Cd2(amstz)2Cl2]n (1) and [Cd2(amstz)2(NO3)2]n (2). Compounds 1 and 2 feature 2-D layered structures based on the dinuclear [Cd2(amstz)2] subunits. The cadmium coordination polyhedra are tetrahedral and tetragonal pyramidal in 1 and 2, respectively, due to the presence of different coordinated anions, Cl− and NO3−. Compounds 1 and 2 exhibit photoluminescence emission with maxima at 620 and 621 nm upon excitation at 470 and 472 nm, respectively, which can be attributed to the ligand-to-metal charge transfer emssion.
Two new heteroleptic ruthenium(II) dithiocarbamates: synthesis, characterization, DFT calculation and DNA binding
Creators: name: Hayat, Faisal
name: Zia-Ur-Rehman
name: Khan, Muhammad Haleem
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Two ruthenium(II) dithiocarbamates, cis-[Ru(DMP)2L](BF4), where L = 4-(4-methoxy-phenyl)piperazine-1-carbodithioate (1) and 4-(3-methoxyphenyl)piperazine-1-carbodithioate (2) and DMP = 2,9-dimethyl-1,10-phenanthroline, have been synthesized and characterized. The DNA-binding affinity of these metal complexes was investigated by UV–visible spectrophotometry with DNA-binding constants of 6.2 × 104 M−1 (1) and 1.2 × 105 M−1 (2) and electrostatic binding mode was confirmed by viscometric measurements. For insight into the structural differences, both complexes were studied computationally. B3LYP/LANL2DZ level of Density Functional Theory was used for the computational studies in Gaussian 09. The optimized bond lengths are in agreement with the reported values. Comparative computational studies reveal interesting transformations in bond lengths, angles, Natural Bond Orbital charges, molecular orbitals, Molecular Electro Static Potentials, and global chemical reactivity indices. Based on quantum chemical results a structure–activity relationship has been attempted.
Two new heteroleptic ruthenium(II) dithiocarbamates: Synthesis, characterization, DFT calculation and DNA binding
Creators: name: Hayat, Faisal
name: Zia-Ur Rehman
name: Khan, Muhammad Haleem
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Two ruthenium(II) dithiocarbamates, cis-[Ru(DMP)2L](BF4), where L = 4-(4-methoxy-phenyl)piperazine-1-carbodithioate (1) and 4-(3-methoxyphenyl)piperazine-1-carbodithioate (2) and DMP = 2,9-dimethyl-1,10-phenanthroline, have been synthesized and characterized. The DNA-binding affinity of these metal complexes was investigated by UV-visible spectrophotometry with DNA-binding constants of 6.2×104 M−1 (1) and 1.2×105 M−1 (2) and electrostatic binding mode was confirmed by viscometric measurements. For insight into the structural differences, both complexes were studied computationally. B3LYP/LANL2DZ level of Density Functional Theory (DFT) was used for the computational studies in Gaussian 09. The optimized bond lengths are in agreement with the reported values. Comparative computational studies reveal interesting transformations in bond lengths, angles, Natural Bond Orbital (NBO) charges, molecular orbitals, Molecular Electro Static Potentials (MESP) and global chemical reactivity indices. Based on quantum chemical results a structure-activity relationship has been attempted.
Lesnauderie, Pierre de, La louenge de mariage et recueil des hystoires des bonnes / vertueuses et illustres femmes, [Paris, ca 1532]
Creators: name: de Lesnauderie, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018

description: Source: Bibliothèque nationale de France, département Arsenal, 4-S-599
description: Relation: vignette : https://www.nakala.fr/data/11280/236ec45e
title: Concours de l'Innovation Paysanne
title: Exploiter le potentiel d’innovation des petits agriculteurs
titleType: AlternativeTitle
Creators: name: Baumüller, Heike
name: Wünscher, Tobias
name: Tambo, Justice A.
Publisher: name: Center for Development Research (ZEF)
Year: 2016
Subjects: subject: Innovation
subject: Research & development
subject: Agricultural production
subject: Crops
subject: Livestock
subject: Fisheries
subject: Food processing
subject: Africa
subject: ddc:300
subject: ddc:630

description: La création des innovations agricoles revient traditionnellement aux organismes de recherche. Le potentiel de l’agriculteur à développer des solutions innovantes était largement négligé. Les concours de l’innovation paysanne au Ghana montrent cependant que les agriculteurs peuvent être une source prometteuse en matière d’innovations adaptées aux conditions locales et pouvant être diffusées rapidement et à moindre coût.
title: Exploring the impact of comments on the blog posts search
Creators: name: Qiu, Sukai
Publisher: name: University of Glasgow
Year: 2009
Subjects: subject: comments,, blog posts search, opinion retrieval, topical relevance retrieval, query independent evidence

description: An important aspect which distinguishes blogs from other web pages is the ability of blog readers to respond to blog posts directly by posting comments. In this study, we focus on the comments information in the blogs. In particular, we explore the use of comments in two blog posts search tasks. One task is topical relevance retrieval which aims to retrieve as many on-topic posts as possible; the other is opinion retrieval which targets not only topical relevant posts but also the ones that contain an opinion about the given topic. We mainly investigate two aspects of comments: volume and content, focusing on the volume aspect. For both search tasks, we view the comments volume as a feature for ranking documents before we know the query (such a feature is called a query independent feature) and apply two established techniques to incorporate a query independent feature in document ranking. Furthermore, we explore the effect of noisy comments which are either irrelevant to their corresponding post in terms of content or are spam comments on the retrieval performance for both search tasks. As for the comments content, we investigate its impact for both search tasks from two angles: how the retrieval performance will be changed if we omit comments content during retrieval and what is the contribution of comments content in retrieving relevant (or relevant opinionated) documents. As a necessary step for all the above work, we extract the comments from the TREC Blogs06 test collection and study various comments statistics. In addition, we explore a proximity-based technique for opinion retrieval which measures the degree of opinion in a document by the proximity between the query terms and the subjective terms in the document.

The experimental results show that using the comments volume feature is generally helpful for both search tasks. However, removing the noisy comments is not helpful for both search tasks, even when varying the level of the noise to be considered. Furthermore, the comments content has an impact on the retrieval performance for both search tasks, verified from both angles. Finally, the proximity-based opinion detection technique only works if an appropriate setting is applied.
title: OFROM: interview avec unine11b01m
Creators: name: Delafontaine, François
name: Augsburger, Sylvie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.46246oi4.v2#0c815619ea3c1b9f52ae56e2cbdb9836160e3dd0
title: Das Wort des Herrn in der neuen Welt : Auf den Spuren einer seltenen Ausgabe mit interessanter Provinienzgeschichte
Creators: name: Parschik, Thomas
Publisher: name: Berufsverband Information Bibliothek (BIB)
Year: 2022

description: Germantown ist eine Kleinstadt im US-Bundesstaat Philadelphia. Gegründet wurde sie im Jahre 1683 von deutschen Auswanderern, die unter der Führung von Franz Daniel Pastorius (1651-1719) mit der Galeone »Concord« ins Land gekommen waren. Dort gründete Wilhelm Rettinghaus (1644-1708) im Jahre 1690 die erste Papiermühle. Der Bedarf an Bibeln in der strenggläubigen Gemeinde war groß.
Gordon A Cain Octec and Vision4ce Papers Abstracts 1.pdf
Creators: name: Cain, Gordon
Publisher: name: figshare
Year: 2016
Subjects: subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Various papers on image processing and video tracking with Gordon cain as autor or part author
title: OFROM: interview avec unine11a08m
Creators: name: Delafontaine, François
name: Caillaud, Cécile
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.748dv475.v2#52235a543f42c86af357cd6324b752405c033254
title: OFROM: interview avec unine11a07m
Creators: name: Delafontaine, François
name: Pauchard, Justine
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.7291kpe6.v2#0b59ec33a6cd57c2b42760f09f62207f53d53e4f
title: 03_0496
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Obama Science Advisory Committee
Creators: name: Westneat, Mark
Publisher: name: figshare
Year: 2016
Subjects: subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Behavioral Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Environmental Science
subject: Climate Science
subject: Applied Computer Science
subject: 29999 Physical Sciences not elsewhere classified
subject: Science Policy

description: Report of the Science Policy Advisory Committee for the Campaign to Elect Barack Obama President of the United States
Obama Platform 2008 Science Fact Sheet
Creators: name: Westneat, Mark
Publisher: name: figshare
Year: 2016
Subjects: subject: Space Science
subject: Planetary Science
subject: Behavioral Neuroscience
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Atmospheric Sciences
subject: FOS: Earth and related environmental sciences
subject: Environmental Science
subject: Climate Science
subject: 40305 Marine Geoscience
subject: 110399 Clinical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: Applied Computer Science
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Scientific aims and talking points drafted for the 2008 Obama campaign by the Science Policy Advisory Committee for the Campaign to Elect Barack Obama President of the United States
title: OFROM: interview avec unine11a06m
Creators: name: Delafontaine, François
name: Mathez, Muriel
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.a1844nfc.v2#9ec889cba101d56af9b5c8c1f669db2da64dc96c