cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
English variety: popular theater and the post-consensus novel
Creators: name: Harris, Scott Charles
Publisher: name: No Publisher Supplied
Year: 2021

description: English Variety sets out to explain the late–twentieth-century English’s novel’s interest in a series of performance genres native to an archaic tradition of popular theatrical entertainment. It does so by reading what I call “the novel of variety” in the context of both a renewed critical interest in English national culture, and an urgently felt need to reassess the possibility of postimperial collectivity marked by racial, ethnic, sexual, and cultural difference. As I understand it, the novel’s belated uptake of popular theatrical genres like pantomime, comic monologue, and male impersonation represents a form of generic dynamism that mirrors the social dynamism of popular theatrical enterprise, that is, by simulating the theater’s defining attributes: its variousness, its vulgarity, its topicality, and so forth. Moreover, the novelists at the center of this project—Salman Rushdie, Angela Carter, Sarah Waters, and Ian McEwan—recognize that the theater, unlike the novel, depends upon embodiment, co-presence, and collective enterprise; as such, they strive to adapt the theater’s forms in order to dramatize more clearly the novel’s relationship to the social. In taking on the social and generic features of the popular theater, then, the contemporary novel performs its own commitment to vernacular, populist collectivity, a kind of collectivity that assembles around popular will rather than democratic protocol, and thus becomes a more capacious genre for organizing people and managing difference. In moving away from Benedict Anderson’s “imagined community” as a primary marker of national culture in the novel, English Variety focuses on micropolitical scales in which the collectivity that thrives in spontaneous, even amateurish, entertainment genres substitutes for abstract notions of civic belonging. In short, theatrical variety expands the contemporary novel’s methods for representing the social, and, in the process, helps to diversify Englishness as a demographic category. To this end, I suggest we make space for “the novel of variety” in our critical histories of the late-century British novel.
Seeds Don't Sink: Even Massive Black Hole "Seeds" Cannot Migrate to Galaxy Centers Efficiently
Creators: name: Ma, Linhao
name: Hopkins, Philip F.
name: Ma, Xiangcheng
name: Anglés-Alcázar, Daniel
name: Faucher-Giguère, Claude-André
name: Kelley, Luke Zoltan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Possible formation scenarios of supermassive black holes in the early universe include rapid growth from less massive seed black holes (BHs) via super-Eddington accretion or runaway mergers, yet both of these scenarios would require seed BHs to efficiently sink to and be trapped in the galactic center via dynamical friction. This may not be true for their complicated dynamics in clumpy high-$z$ galaxies. In this work we study this "sinking problem" with state-of-the-art high-resolution cosmological simulations, combined with both direct $N$-body integration of seed BH trajectories and post-processing of randomly generated test particles with a newly developed dynamical friction estimator. We find that seed BHs less massive than $10^8\,M_\odot$ (i.e., all but the already-supermassive seeds) cannot efficiently sink in typical high-$z$ galaxies. We also discuss two possible solutions: dramatically increasing the number of seeds such that one seed can end up trapped in the galactic center by chance, or seed BHs being embedded in dense structures (e.g. star clusters) with effective masses above the mass threshold. We discuss the limitations of both solutions.
description: accepted to MNRAS
GRB efficiency and Possible Physical Processes Shaping the Early Afterglow
Creators: name: Fan, Yizhong
name: Piran, Tsvi
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The discovery by Swift that a good fraction of Gamma Ray Bursts (GRBs) have a slowly decaying X-ray afterglow phase led to the suggestion that energy injection into the blast wave takes place several hundred seconds after the burst. This implies that right after the burst the kinetic energy of the blast wave was very low and in turn the efficiency of production of $γ$-rays during the burst was extremely high, rendering the internal shocks model unlikely. We re-examine the estimates of kinetic energy in GRB afterglows and show that the efficiency of converting the kinetic energy into gamma-rays is moderate and does not challenge the standard internal shock model. We also examine several models, including in particular energy injection, suggested to interpret this slow decay phase. We show that with proper parameters, all these models give rise to a slow decline lasting several hours. However, even those models that fit all X-ray observations, and in particular the energy injection model, cannot account self-consistently for both the X-ray and the optical afterglows of well monitored GRBs such as GRB 050319 and GRB 050401. We speculate about a possible alternative resolution of this puzzle.
description: Accepted for publication in MNRAS, minor revision
Interstate Safety Improvement Program
Creators: name: Pigman, Jerry G.
name: Agent, Kenneth R.
name: Zegeer, Charles V.
Publisher: name: Kentucky Transportation Center, University of Kentucky
Year: 1979
Subjects: subject: Transportation Engineering

description: A previous report dealt with development of procedures for preparation of an Interstate Safety Improvement Program. The purpose of this report was to prepare prioritized rankings of recommended improvements which could be implemented for the Interstate Safety Improvement Program. Together, these two reports include logical and comprehensive procedures for the selection, scheduling, construction, and evaluation of highway safety improvement projects.  Considerable detail is presented which documents analysis procedures used to determine sites, sections, and elements of the roadway in need of improvement. The average number of accidents per interchange, bridge, 1.0-mile (1.6-km) section, and 0.3-mile (0.48-km) spots were summarized for large urban, medium urban, and rural sections of the interstate system. At specified levels of statistical significance, critical numbers of accidents and critical accident rates were calculated to assist in identifying high-accident locations. A limited field inventory of the interstate system was conducted and the results are incorporated into the program. Dynamic programming was utilized as the means of developing prioritized rankings for safety improvements totaling approximately $27,500,000. Example budgets ranging from $5,000,000 to $30,000,000 are also presented.
Dependence of Galaxy Shape on Environment in the Sloan Digital Sky Survey
Creators: name: Kuehn, Frederick
name: Ryden, Barbara S.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Using a sample of galaxies from the Sloan Digital Sky Survey (SDSS) Data Release 4, we study the trends relating surface brightness profile type and apparent axis ratio to the local galaxy environment. We use the SDSS parameter `fracDeV' to quantify the profile type. We find that galaxies with M_r > -18 are mostly described by exponential profiles in all environments. Galaxies with -21 < M_r < -18 mainly have exponential profiles in low density environments and de Vaucouleurs profiles in high density environments. The most luminous galaxies, with M_r < -21, are mostly described by de Vaucouleurs profiles in all environments. For galaxies with M_r < -19, the fraction of de Vaucouleurs galaxies is a monotonically increasing function of local density, while the fraction of exponential galaxies is monotonically decreasing. For a fixed surface brightness profile type, apparent axis ratio is frequently correlated with environment. As the local density of galaxies increases, we find that for -20 < M_r < -18, galaxies of all profile types become slightly rounder, on average; for -22 < M_r < -20, galaxies with exponential profiles tend to become flatter, while galaxies with de Vaucouleurs profiles become rounder; for M_r < -22, galaxies with exponential profiles become flatter, while the de Vaucouleurs galaxies become rounder in their inner regions, yet exhibit no change in their outer regions. We comment on how the observed trends relate to the merger history of galaxies.
description: 23 pages, 7 figures, accepted by ApJ
title: Measuring the value of varsity athletics through student retention and the balanced scorecard strategy
Creators: name: Davidson, Reid E.R.
Publisher: name: VIU Press
Year: 2021
Subjects: subject: College sports
subject: Vancouver Island University--Sports
subject: College athletes

description: This case study attempts to determine the value of student athletic programs at Canadian universities, using Vancouver Island University (VIU) as a reference case. First, the study compares Canadian varsity athletics to American collegiate athletics to consider the relative economic value of collegiate athletics between the two countries. Second, the study assesses graduation rates and retention of student athletes in Canadian varsity programs as an indicator of the academic value of these programs. Graduation rates and ten-year trends were found using data retrieved from VIU records of past athletes and the credentials they received. Finally, the Balanced Scorecard (BSC) strategy was also employed to explore ways for institutions to create more value for their athletic departments. The BSC strategy focuses on four main pillars of business that have unique objectives and measures to ensure goals are completed. These strategies can be used to create value by reliably predicting outcomes. Value can be perceived in several non-financial ways from an institutional standpoint, including student success, athletic reputation, or pride in school culture among students and staff. Using the BSC could help Canadian collegiate athletic programs overcome the many barriers that stand in the way of sustainable operations. In this case study, we discovered that, with the overwhelming difference in resources between the US and Canada, Canadian varsity athletics may need to find new ways to engage stakeholders after a year of low activity due to the pandemic. Moreover, results of the graduation data indicate that VIU, the test institution, has had a dramatic incline in academic success since 2016 and that the strategies that have been set in place have fostered a more nurturing educational environment for its athletes. It will be important to continue this type of research among all institutions in the U-Sport/Canadian Collegiate Athletic Association (CCAA) to refresh the current systems in place that yield little return on investment (ROI) for stakeholders. With the suggested strategies in this case study, user groups and stakeholders should see noticeable improvement from four different perspectives: internal, external, financial, and innovation/learning and growth. The BSC is a great tool because it does not require a massive modification of operations. It is a cost-effective solution to scoping in on one area of need at a time if necessary. The information gained may be incredibly useful for determining how to improve one’s athletic department.
Accounting for object detection bias in weak gravitational lensing studies
Creators: name: Hoekstra, Henk
name: Kannawadi, Arun
name: Kitching, Thomas D.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Weak lensing by large-scale structure is a powerful probe of cosmology if the apparent alignments in the shapes of distant galaxies can be accurately measured. Most studies have therefore focused on improving the fidelity of the shape measurements themselves, but the preceding step of object detection has been largely ignored. In this paper we study the impact of object detection for a Euclid-like survey and show that it leads to biases that exceed requirements for the next generation of cosmic shear surveys. In realistic scenarios, blending of galaxies is an important source of detection bias. We find that MetaDetection is able to account for blending, leading to average multiplicative biases that meet requirements for Stage IV surveys, provided a sufficiently accurate model for the point spread function is available. Further work is needed to estimate the performance for actual surveys. Combined with sufficiently realistic image simulations, this provides a viable way forward towards accurate shear estimates for Stage IV surveys.
description: version accepted by A&A; 24 pages; included reference to companion paper Kannawadi et al. arXiv:2010.04164
title: Statewide Survey of Skid Resistances of Pavements
title: (1978)
titleType: Subtitle
Creators: name: Rizenbergs, Rolands L.
name: Burchett, James L.
Publisher: name: Kentucky Transportation Center, University of Kentucky
Year: 1979
Subjects: subject: Transportation Engineering

description: Statewide survey of skid resistances continued in 1978 with the testing of 2,943 miles (4,736 km) of state primary roads and 2,405 miles (3,870 km) of state secondary roads. About 10 percent of both the state primary mileage and the state secondary mileage had an average skid number of 28 or less. These pavements, in pariticular, should be considered for de-slicking.  In 1977 and 1978, 35 percent of the mileage of rural, state-maintained roads in Kentucky were surveyed. These roads carried 87 percent of all traffic on rural, state-maintained roads.
Identification confusion and blending concealment in the SDSS-DR16 Quasar catalogues -- 40 new quasars and 82 false quasars identified
Creators: name: Flesch, Eric Wim
Publisher: name: arXiv
Year: 2020
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The SDSS-DR16 Quasar Superset and pipeline catalogues are searched for undeclared quasars which were concealed by or confused with other objects, usually due to incomplete deblending. Forty such quasars with redshifts are found and herewith presented. Also, 82 entries in the SDSS-DR16Q main quasar catalogue are shown to be non-quasars, some also due to incomplete deblending, especially "line poachers". Other non-quasars are shown to be star spikes or moving stars or other types, and 7 new quasars are identified from analysis of "unplugged" spectra. These numbers are tiny compared with the millions of DR16 spectra, but highlight some heretofore overlooked systematics. The deblending issue is discussed throughout.
description: Accepted by Monthly Notices of the Royal Astronomical Society. 14 pages, 22 figures, 2 tables
Measurements of $Jψ$ decays into $ωπ^0$, $ωη$, and $ωη'$
Creators: name: Ablikim, M.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Based on $5.8 \times 10^7 Jψ$ events collected with BESII at the Beijing Electron-Positron Collider (BEPC), the decay branching fractions of $Jψ\toωπ^0$, $ωη$, and $ωη'$ are measured using different $η$ and $η'$ decay modes. The results are higher than previous measurements. The $ωπ^0$ electromagnetic form factor is also obtained.
description: 10 pages, 12 figures
Additional file 1 of Survey self-report of rheumatoid arthritis and treatments versus specialist clinician confirmation
Creators: name: Jugnundan, Shamil
name: Schmajuk, Gabriela
name: Trupin, Laura
name: Blanc, Paul D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Supplementary Material 1
title: Lors de décès en soins palliatifs pédiatriques quel accompagnement infirmier proposer à la fratrie ?
title: Lors de décès en soins palliatifs pédiatriques quel accompagnement infirmier proposer à la fratrie ?
titleType: AlternativeTitle
Creators: name: Vuadens, Émilie
name: Cheevers, Jessie Jane
Publisher: name: Unknown
Year: 0
Subjects: subject: fratries
subject: deuil
subject: besoins
subject: soutien aux fratries
subject: deuil compliqué
subject: soins infirmiers
subject: soins palliatifs
subject: soins pédiatriques
subject: hesav TB SI

description: Introduction : En Suisse, près de 500 enfants décèdent chaque année. La moitié d’entre eux succombe à la suite de maladies engageant le pronostic vital. Ces chiffres signifient indirectement que de nombreuses fratries vivent le deuil de leur frère ou de leur sœur. Le deuil de l’enfant se décrit comme complexe ; il est peu considéré par les familles et les professionnels de la santé. Plusieurs études exposent les conséquences psychopathologiques du deuil sur le développement de l’enfant. En revanche, peu de recommandations sont établies et mises en pratique par le personnel infirmier. Objectifs : Identifier les besoins des fratries endeuillées et l’accompagnement infirmier. Méthode : Revue de littérature effectuée à l’aide des bases de données CINAHL et PubMed qui a permis de sélectionner six articles qualitatifs et quantitatifs. Résultats : La revue de littérature expose les besoins des fratries avant, pendant et après le décès de l’enfant. Les facteurs influençant le processus de deuil sont liés aux besoins des fratries. Elles souhaitent être informées de l’état de santé et de l’évolution de la maladie. Les fratries expriment également le besoin d’avoir un soutien et d’être entourées par leur proches et par les professionnels de la santé. Les résultats démontrent que la préparation au décès et la continuité du soutien est indispensable. Être présent pour les fratries, leur offrir un espace de parole et une prise de contact après la mort semblent bénéfique. Conclusion : L’accompagnement des fratries est du ressort des infirmières1. Elles s’assurent des ressources que disposent les fratries face à la maladie et au deuil. L’utilisation du modèle de la systémique familiale de Calgary représente un cadre conceptuel idéal pour la mise en pratique des recommandations.
title: Cell‐Based Optimization of Covalent Reversible Ketoamide Inhibitors Bridging the Unprimed to the Primed Site of the Proteasome β5 Subunit
Creators: name: Stubba, Daniel
name: Bensinger, Dennis
name: Steinbacher, Janika
name: Proskurjakov, Lilia
name: Salcedo Gómez, Álvaro
name: Schmidt, Uwe
name: Roth, Stefan
name: Schmitz, Katja
name: Schmidt, Boris
Publisher: name: Wiley-VCH
Year: 2024

description: The ubiquitin‐proteasome system (UPS) is an established therapeutic target for approved drugs to treat selected hematologic malignancies. While drug discovery targeting the UPS focuses on irreversibly binding epoxyketones and slowly‐reversibly binding boronates, optimization of novel covalent‐reversibly binding warheads remains largely unattended. We previously reported α‐ketoamides to be a promising reversible lead motif, yet the cytotoxic activity required further optimization. This work focuses on the lead optimization of phenoxy‐substituted α‐ketoamides combining the structure‐activity relationships from the primed and the non‐primed site of the proteasome β5 subunit. Our optimization strategy is accompanied by molecular modeling, suggesting occupation of P1′ by a 3‐phenoxy group to increase β5 inhibition and cytotoxic activity in leukemia cell lines. Key compounds were further profiled for time‐dependent inhibition of cellular substrate conversion. Furthermore, the α‐ketoamide lead structure 27 does not affect escape response behavior in Danio rerio embryos, in contrast to bortezomib, which suggests increased target specificity.
Replacing vertical actions by mouse movements: A web-based paradigm for investigating vertical spatial associations
Creators: name: Schütt, Emanuel
name: Mackenzie, Ian G.
name: Kaup, Barbara
name: Dudschig, Carolin
Publisher: name: Zenodo
Year: 2021

description: The folder contains data and code associated with the project "Replacing vertical actions by mouse movements: A web-suited paradigm for investigating vertical spatial associations".
Additional file 2 of Survey self-report of rheumatoid arthritis and treatments versus specialist clinician confirmation
Creators: name: Jugnundan, Shamil
name: Schmajuk, Gabriela
name: Trupin, Laura
name: Blanc, Paul D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Supplementary Material 2
Data-assisted combustion simulations with dynamic submodel assignment using random forests
Creators: name: Chung, Wai Tong
name: Mishra, Aashwin Ananda
name: Perakis, Nikolaos
name: Ihme, Matthias
Publisher: name: arXiv
Year: 2020
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Machine Learning (cs.LG)
subject: Computational Physics (physics.comp-ph)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In this investigation, we outline a data-assisted approach that employs random forest classifiers for local and dynamic combustion submodel assignment in turbulent-combustion simulations. This method is applied in simulations of a single-element GOX/GCH4 rocket combustor; a priori as well as a posteriori assessments are conducted to (i) evaluate the accuracy and adjustability of the classifier for targeting different quantities-of-interest (QoIs), and (ii) assess improvements, resulting from the data-assisted combustion model assignment, in predicting target QoIs during simulation runtime. Results from the a priori study show that random forests, trained with local flow properties as input variables and combustion model errors as training labels, assign three different combustion models - finite-rate chemistry (FRC), flamelet progress variable (FPV) model, and inert mixing (IM) - with reasonable classification performance even when targeting multiple QoIs. Applications in a posteriori studies demonstrate improved predictions from data-assisted simulations, in temperature and CO mass fraction, when compared with monolithic FPV calculations. These results demonstrate that this data-driven framework holds promise for the dynamic combustion submodel assignment in reacting flow simulations.
description: Accepted version; 23 pages, 12 figures
Phase transition in a mean-field model for sympatric speciation
Creators: name: Schwämmle, V.
name: Luz-Burgoa, K.
name: Martins, J. S. Sá
name: de Oliveira, S. Moss
Publisher: name: arXiv
Year: 2005
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: We introduce an analytical model for population dynamics with intra-specific competition, mutation and assortative mating as basic ingredients. The set of equations that describes the time evolution of population size in a mean-field approximation may be decoupled. We find a phase transition leading to sympatric speciation as a parameter that quantifies competition strength is varied. This transition, previously found in a computational model, occurs to be of first order.
description: accepted for Physica A
Gutachten der Wissenschaftlerinnen und Wissenschaftler / Expertises des chercheuses et chercheurs
Creators: name: Redaktion, Die
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2021

description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2019/2020
SNEWS 2.0: A Next-Generation SuperNova Early Warning System for Multi-messenger Astronomy
Creators: name: Kharusi, S. Al
name: BenZvi, S. Y.
name: Bobowski, J. S.
name: Bonivento, W.
name: Brdar, V.
name: Brunner, T.
name: Caden, E.
name: Clark, M.
name: Coleiro, A.
name: Colomer-Molla, M.
name: Crespo-Anadón, J. I.
name: Depoian, A.
name: Dornic, D.
name: Fischer, V.
name: Franco, D.
name: Fulgione, W.
name: Rosso, A. Gallo
name: Geske, M.
name: Griswold, S.
name: Gromov, M.
name: Haggard, D.
name: Habig, A.
name: Halim, O.
name: Higuera, A.
name: Hill, R.
name: Horiuchi, S.
name: Ishidoshiro, K.
name: Kato, C.
name: Katsavounidis, E.
name: Khaitan, D.
name: Kneller, J. P.
name: Kopec, A.
name: Kulikovskiy, V.
name: Lai, M.
name: Lamoureux, M.
name: Lang, R. F.
name: Li, H. L.
name: Lincetto, M.
name: Lunardini, C.
name: Migenda, J.
name: Milisavljevic, D.
name: McCarthy, M. E.
name: O'Connor, E.
name: O'Sullivan, E.
name: Pagliaroli, G.
name: Patel, D.
name: Peres, R.
name: Pointon, B. W.
name: Qin, J.
name: Raj, N.
name: Renshaw, A.
name: Roeth, A.
name: Rumleskie, J.
name: Scholberg, K.
name: Sheshukov, A.
name: Sonley, T.
name: Strait, M.
name: Takhistov, V.
name: Tamborra, I.
name: Tseng, J.
name: Tunnell, C. D.
name: Vasel, J.
name: Vigorito, C. F.
name: Viren, B.
name: Virtue, C. J.
name: Wang, J. S.
name: Wen, L. J.
name: Winslow, L.
name: Wolfs, F. L. H.
name: Xu, X. J.
name: Xu, Y.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The next core-collapse supernova in the Milky Way or its satellites will represent a once-in-a-generation opportunity to obtain detailed information about the explosion of a star and provide significant scientific insight for a variety of fields because of the extreme conditions found within. Supernovae in our galaxy are not only rare on a human timescale but also happen at unscheduled times, so it is crucial to be ready and use all available instruments to capture all possible information from the event. The first indication of a potential stellar explosion will be the arrival of a bright burst of neutrinos. Its observation by multiple detectors worldwide can provide an early warning for the subsequent electromagnetic fireworks, as well as signal to other detectors with significant backgrounds so they can store their recent data. The Supernova Early Warning System (SNEWS) has been operating as a simple coincidence between neutrino experiments in automated mode since 2005. In the current era of multi-messenger astronomy there are new opportunities for SNEWS to optimize sensitivity to science from the next Galactic supernova beyond the simple early alert. This document is the product of a workshop in June 2019 towards design of SNEWS 2.0, an upgraded SNEWS with enhanced capabilities exploiting the unique advantages of prompt neutrino detection to maximize the science gained from such a valuable event.
description: 66 pages, 11 figures
Lehre der Wissenschaftlerinnen und Wissenschaftler / Enseignement des chercheuses et chercheurs
Creators: name: Redaktion, Die
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2021

description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2019/2020
Additional file 1 of Patients with low prognosis in ART: a Delphi consensus to identify potential clinical implications and measure the impact of POSEIDON criteria
Creators: name: Alviggi, Carlo
name: Humaidan, Peter
name: Fischer, Robert
name: Conforti, Alessandro
name: Dahan, Michael H.
name: Marca, Antonio La
name: Orvieto, Raoul
name: Polyzos, Nikolaos P.
name: Roque, Matheus
name: Sunkara, Sesh K.
name: Ubaldi, Filippo Maria
name: Vuong, Lan
name: Yarali, Hakan
name: D’Hooghe, Thomas
name: Longobardi, Salvatore
name: Esteves, Sandro C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Hematology

description: Supplementary Material 1
Cross correlation of Lyman-alpha absorbers with gas-rich galaxies
Creators: name: Ryan-Weber, Emma V.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The HI Parkes All Sky Survey (HIPASS) galaxy catalogue is cross-correlated with known low redshift, low column density (N_HI <10^15 cm^-2) Lyman-alpha absorbers from the literature. The redshift-space correlation is found to be similar in strength to HIPASS galaxy self-clustering (correlation length s_0,ag=6+/-4 and s_0,gg=3.1+/-0.5 h^-1 Mpc respectively). In real-space the cross-correlation is stronger than the galaxy auto-correlation (correlation length r_0,ag=7.2+/-1.4 and r_0,gg=3.5+/-0.7 h^-1 Mpc respectively) on scales from 1-10 h^-1 Mpc, ruling out the mini-halo model for the confinement Lyman-alpha absorbers at the 99 percent confidence level. Provided that the cause of the strong cross-correlation is purely gravitational, the ratio of correlation lengths suggest that absorbers are embedded in dark matter haloes with masses log(M/Msun)=14.2 h^-1, similar to those of galaxy groups. The flattening of the cross-correlation at separations less than ~600 h^-1 kpc could correspond to the thickness of filaments in which absorbers are embedded. This work provides indirect statistical evidence for the notion that galaxy groups and large-scale filaments, particularly those that comprise gas-rich galaxies, are the dominant environments of low column density Lyman-alpha absorbers at z=0.
description: 10 pages, 10 figures, accepted for publication in MNRAS, minor typos fixed and references updated
Formation of GW190521 from stellar evolution: the impact of the hydrogen-rich envelope, dredge-up and $^{12}$C($α$, $γ$)$^{16}$O rate on the pair-instability black hole mass gap
Creators: name: Costa, Guglielmo
name: Bressan, Alessandro
name: Mapelli, Michela
name: Marigo, Paola
name: Iorio, Giuliano
name: Spera, Mario
Publisher: name: arXiv
Year: 2020
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Pair-instability (PI) is expected to open a gap in the mass spectrum of black holes (BHs) between $\approx{}40-65$ M$_\odot$ and $\approx{}120$ M$_\odot$. The existence of the mass gap is currently being challenged by the detection of GW190521, with a primary component mass of $85^{+21}_{-14}$ M$_{\odot}$. Here, we investigate the main uncertainties on the PI mass gap: the $^{12}$C($α$, $γ$)$^{16}$O reaction rate and the H-rich envelope collapse. With the standard $^{12}$C($α$, $γ$)$^{16}$O rate, the lower edge of the mass gap can be 70 M$_\odot$ if we allow for the collapse of the residual H-rich envelope at metallicity $Z\leq{}0.0003$. Adopting the uncertainties given by the STARLIB database, for models computed with the $^{12}$C($α$, $γ$)$^{16}$O rate $-1\, σ$, we find that the PI mass gap ranges between $\approx{}80$ M$_\odot$ and $\approx{}150$ M$_\odot$. Stars with $M_{\rm ZAMS}>110$ M$_\odot$ may experience a deep dredge-up episode during the core helium-burning phase, that extracts matter from the core enriching the envelope. As a consequence of the He-core mass reduction, a star with $M_{\rm ZAMS} =160$ M$_\odot$ may avoid the PI and produce a BH of 150 M$_\odot$. In the $-2\,{}σ$ case, the PI mass gap ranges from 92 M$_\odot$ to 110 M$_\odot$. Finally, in models computed with $^{12}$C($α$, $γ$)$^{16}$O $-3\,{}σ$, the mass gap is completely removed by the dredge-up effect. The onset of this dredge-up is particularly sensitive to the assumed model for convection and mixing. The combined effect of H-rich envelope collapse and low $^{12}$C($α$, $γ$)$^{16}$O rate can lead to the formation of BHs with masses consistent with the primary component of GW190521.
description: 20 pages, 16 figures, accepted for publication in MNRAS
Plastid transformation biotechnology: increasing efficiency and expanding application
Creators: name: LaManna, Lisa
Publisher: name: No Publisher Supplied
Year: 2021

description: Plastid transformation biotechnology holds great potential for many agricultural and pharmaceutical applications, including the development of insect tolerance by expressing dsRNAs, high-level production of bioencapsulated vaccines and antibodies, producing novel metabolic pathways and improving photosynthetic efficiency. However, the plastid transformation technology has yet to become a developed tool in most crop plants.I was part of the group that developed a system for plastid transformation in Arabidopsis thaliana, a Brassicaceae species, that is potentially applicable to other Brassica species including rapa (turnip, napa cabbage, bok choy), oleracea (broccoli, kale, cauliflower, and cabbage), and napus (oilseed), which are major constituents of the vegetables and vegetable-based products consumed globally. Efficient plastid transformation in Arabidopsis is enabled by eliminating a duplicate fatty acid biosynthetic pathway in chloroplasts. Moreover, the use of a robust tissue culture system increases the number of events acquired from each experiment, enhancing the overall efficiency of the Arabidopsis plastid transformation system.Infertility in regenerated Arabidopsis transplastomic shoots disables routine use of the plastid transformation system, but a relative, Brassica napus, holds great potential to overcome this bottleneck. To expand plastid transformation here, I generated the tissue culture protocol and tested the plastid transformation efficiency in the newly developed acc2-knockout lines using new plastid transformation vectors for efficient screening of transformed events. Plastid transformation technology in B. napus has a host of applications, such as the increasing seed oil content in the Westar cultivar, the pedigree line that produces canola vegetable oil.Plastid transformation technology has the potential to greatly impact the pharmaceutical industry. Most therapeutic protein drugs are currently produced on bacterial and yeast platforms, the same basic platforms used since the 1970s. These systems require extensive purification processes and cold storage for transportation, which drive up the costs beyond what is affordable by most people worldwide. The high-level expression platform presented by plastid transformation can overcome many of the manufacturing hurdles incurred by the antiquated systems, while bioencapsulation by the chloroplast presents a system of storage and bioavailability that obviates costly purification processes. Furthermore, a plant production platform for therapeutic drugs can be made available wherever there is need, simply by providing the seeds, and scaled up quickly with straightforward agricultural practices. My project in producing recombinant muscle regulators in tobacco chloroplasts queries the potential of chloroplast transformation for its effectiveness as a competitive therapeutic protein production platform and an alternative to needle-based delivery.
Final report on activities carried out for enhancing excellent scientific research in MILIEU
Creators: name: MILIEU H2020 Project
name: Ruiz Terol, Ingrid
name: Hanninen, Liisa Irene
name: Pavón Mestras, Juan
Publisher: name: Zenodo
Year: 2023

description: D3.2 provides a comprehensive and detailed report on MILIEU activities performed for enhancing scientific excellence and innovation in research capacities in the fields related to inclusion, disability, and women studies within the three partners of the MILIEU consortium, and in particular, within IPS-BAS, with important snowball effects in other academic and research organisations that have been reached through the diverse project actions. The current deliverable is based on the guidelines of the D2.2 Strategic plan for enhancing scientific excellence and D3.1 Visibility and empowerment guidelines which draft the key strategic goals and the specific actions to be implemented to reach the pre-established goals, as well as their estimated timing. This deliverable covers the action taken within WP3 Strengthening the research profile at IPS, in the quest of enhanced scientific excellence. It details the activities carried out within the framework of the MILIEU strategic plan, organised by the following types of action: training courses, qualitative sessions, visibility through networking events and activities, conferences and workshops, joint research project proposals, RRI in project practice, and last but not least, visits and secondments.
The Weak Scale as a Trigger
Creators: name: Arkani-Hamed, Nima
name: D'Agnolo, Raffaele Tito
name: Kim, Hyung Do
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Does the value of the Higgs mass parameter affect the expectation value of local operators in the Standard Model? For essentially all local operators the answer to this question is "no", and this is one of the avatars of the hierarchy problem: nothing is "triggered" when the Higgs mass parameter crosses zero. In this letter, we explore settings in which Higgs mass parameters $can$ act as a "trigger" for some local operators ${\cal O}_T$. In the Standard Model, this happens for ${\cal O}_T = {\rm Tr} (G \tilde G)$. We also introduce a "type-0" two Higgs doublet model, with a $Z_4$ symmetry, for which ${\cal O}_T = H_1 H_2$ is triggered by the Higgs masses, demanding the existence of new Higgs states necessarily comparable to or lighter than the weak scale, with no wiggle room to decouple them whatsoever. Surprisingly, this model is not yet entirely excluded by collider searches, and will be incisively probed by the high-luminosity run of the LHC, as well as future Higgs factories. We also discuss a possibility for using this trigger to explain the origin of the weak scale, invoking a landscape of extremely light, weakly interacting scalars $ϕ_i$, with a coupling to ${\cal O}_T$ needed to make it possible to find vacua with small enough cosmological constant. The weak scale trigger links the tuning of the Higgs mass to that of the cosmological constant, while coherent oscillations of the $ϕ_i$ can constitute dark matter.
description: 23 pages, 9 figures [added references and expanded discussion of 2HDM cosmology]
Development of degradable hydrogel capsules for mesenchymal stem cell expansion
Creators: name: Cabales, Alrick
Publisher: name: No Publisher Supplied
Year: 2021

description: Mesenchymal stem cells have been an attractive cell source for cell-based therapies and regenerative medicines due to their multilineage differentiation and immunomodulatory capabilities; however, the commercial use of these cells is limited by large-scale manufacturing methods of cells. There has been much reported success in designing scale-up approaches to propagating MSCs, such as hollow fiber bioreactors and microcarriers, being able to reduce labor intensity and increase cell yields compared to traditional cell culturing methods. Yet, even these approaches are limited in their scalability and risk damaging the cells. Herein, a hydrogel encapsulation approach is developed as a means to efficiently expand MSCs and overcome the previously reported complications of scale-up approaches. The proposed hydrogel is comprised of polyethylene glycol in addition to naturally derived components native to mammalian extracellular matrix (ECM), namely thiolated gelatin and thiolated hyaluronic acid; cells suspended in the polymer solution are formed into droplets and allowed to polymerize via a thiol-michael addition reaction such that the newly formed polymer spheres can be cultured in suspension. Our results indicate, that although early in design stages, cell proliferation does seem to occur, and with further optimization and quality assurance testing, this system can be transitioned to an industrial setting for the commercial expansion of MSCs and adapted to other adherent cell types.
Vorträge der Wissenschaftlerinnen und Wissenschaftler / Conférences des chercheuses et chercheurs
Creators: name: Redaktion, Die
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2021

description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2019/2020
Bibliografien der Wissenschaftlerinnen und Wissenschaftler / Publications des chercheuses et chercheurs
Creators: name: Redaktion, Die
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2021

description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2019/2020
Análisis preliminar de la potencialidad de las diferentes subregiones genómicas de SARS-Cov-2 para su uso como marcadores filogenéticos
Creators: name: Pupo-Meriño, Mario
name: Jiménez Garí, Jorge A.
name: Castro Martínez, Camila
name: Ramaya Soler, Kamila A
name: Oliva Gregorio, Antonio de Jesus
name: Ramos Bermúdez, Pablo E
name: Rodriguez Cruz, Yasniel
name: Morffi Hidalgo, Lienny
name: González González, Cecilia De La Caridad
Publisher: name: figshare
Year: 2021
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: The use of phylogenetic tools could be key in making decisions in the management of epidemics. Phylogenetic reconstruction requires appropriate markers, which contain the necessary information and allow reconstructing the evolutionary history of the pathogen. For the study of SARS-Cov-2 at the international level, multiple complete genomes of the virus have been sequenced starting from isolates from several countries. This information, available in international databases, has facilitated phylogenomic studies. In the case of Cuba, technological capabilities do not allow complete genomes to be sequenced, which makes it necessary to evaluate the different SARS-Cov-2 genomic regions for their potential use as sources of information. This work describes an analysis, carried out at the beginning of the pandemic, of the genomic regions of SARS-Cov-2, to evaluate their possible use as phylogenetic markers. For this, sequences and public tools were used, taking into account their variability, tendency to saturation and presence of noise, in addition to evaluating their ability to reconstruct the same phylogenetic relationships as those obtained with the analysis of the entire genome. Due to the relatively low evolutionary rate of the virus, and the short time that has elapsed since the beginning of the transmission of SARS-Cov-2 in humans at the time of the study, it is observed that the variability in the individual genomic regions does not contribute the same level of information, that the complete genome, and that the length of the selected segment and the taxonomic sampling are decisive in the resolution capacity of the phylogenetic methods used.
Tätigkeiten der Wissenschaftlerinnen und Wissenschaftler / Activités des chercheuses et chercheurs
Creators: name: Redaktion, Die
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2021

description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2019/2020
title: A discontinuous Galerkin immersed boundary solver for compressible flows: Adaptive local time stepping for artificial viscosity-based shock‐capturing on cut cells
Creators: name: Geisenhofer, Markus
name: Kummer, Florian
name: Müller, Björn
Publisher: name: John Wiley & Sons
Year: 2024

description: We present a higher‐order cut cell immersed boundary method (IBM) for the simulation of high Mach number flows. As a novelty on a cut cell grid, we evaluate an adaptive local time stepping (LTS) scheme in combination with an artificial viscosity–based shock‐capturing approach. The cut cell grid is optimized by a nonintrusive cell agglomeration strategy in order to avoid problems with small or ill‐shaped cut cells. Our approach is based on a discontinuous Galerkin discretization of the compressible Euler equations, where the immersed boundary is implicitly defined by the zero isocontour of a level set function. In flow configurations with high Mach numbers, a numerical shock‐capturing mechanism is crucial in order to prevent unphysical oscillations of the polynomial approximation in the vicinity of shocks. We achieve this by means of a viscous smoothing where the artificial viscosity follows from a modal decay sensor that has been adapted to the IBM. The problem of the severe time step restriction caused by the additional second‐order diffusive term and small nonagglomerated cut cells is addressed by using an adaptive LTS algorithm. The robustness, stability, and accuracy of our approach are verified for several common test cases. Moreover, the results show that our approach lowers the computational costs drastically, especially for unsteady IBM problems with complex geometries.
Tails of the dynamical structure factor of 1D spinless fermions beyond the Tomonaga approximation
Creators: name: Teber, Sofian
Publisher: name: arXiv
Year: 2005
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We consider one-dimensional (1D) interacting spinless fermions with a non-linear spectrum in a clean quantum wire (non-linear bosonization). We compute diagrammatically the 1D dynamical structure factor, $S(\om,q)$, beyond the Tomonaga approximation focusing on it's tails, $|\om| \gg vq$, {\it i.e.} the 2-pair excitation continuum due to forward scattering. Our methodology reveals three classes of diagrams: two "chiral" classes which bring divergent contributions in the limits $\om \to \pm vq$, {\it i.e.} near the single-pair excitation continuum, and a "mixed" class (so-called Aslamasov-Larkin or Altshuler-Shklovskii type diagrams) which is crucial for the f-sum rule to be satisfied. We relate our approach to the T=0 ones present in the literature. We also consider the $T\not=0$ case and show that the 2-pair excitation continuum dominates the single-pair one in the range: $|q|T/k_F \ll \om \mp vq \ll T$ (substantial for $q \ll k_F$). As applications we first derive the small-momentum optical conductivity due to forward scattering: $σ\sim 1/\om$ for $T \ll \om$ and $σ\sim T/\om^2$ for $T \gg \om$. Next, within the $2-$pair excitation continuum, we show that the attenuation rate of a coherent mode of dispersion $Ω_q$ crosses over from $γ_q \propto Ω_q (q/k_F)^2$, {\it e.g.} $γ_q \sim |q|^3$ for an acoustic mode, to $γ_q \propto T (q/k_F)^2$, independent of $Ω_q$, as temperature increases. Finally, we show that the $2-$pair excitation continuum yields subleading curvature corrections to the electron-electron scattering rate: $τ^{-1} \propto V^2 T + V^4 T^3/\eps_F^2$, where $V$ is the dimensionless strength of the interaction.
description: (v4) Published version. Details of calculations given (/ referee's comments). No change in previous results. 13 pages, 4 figures. (v3) Extended version (/ referee's comments and recent literature). No change in previous results. 8 pages, 4 figures. (v2) 4 pages, 4 figures. Submitted version (rapid note in EPJB). Kinetic arguments reduced to a footnote. 2 references added
On sparse perfect powers
Creators: name: Moscariello, Alessio
Publisher: name: arXiv
Year: 2021
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11D41, 11P99

description: This work is devoted to proving that, given an integer $x \ge 2$, there are infinitely many perfect powers, coprime with $x$, having exactly $k \ge 3$ non-zero digits in their base $x$ representation, except for the case $x=2, k=4$, for which a known finiteness result by Corvaja and Zannier holds.
description: 9 pages