cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sensorineural hearing loss in Lyme neuroborreliosis
Creators: name: Jensen, Elisa Skovgaard
name: Cayé-Thomasen, Per
name: Bodilsen, Jacob
name: Hansen, Birgitte Rønde
name: Hovmand, Nichlas
name: Winther, Rannvá
name: Kirchmann, Malene
name: Brandt, Christian T.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Sensorineural hearing loss (SNHL) has been suggested to occur in patients with Lyme neuroborreliosis (LNB); however, a clear association has never been documented. The present study prospectively investigated the development of SNHL in patients admitted for treatment of LNB using distortion-product-oto-acoustic emissions (DPOAE) as a measure of cochlear function. DOAE were measured in patients with LNB on the day of diagnosis, during treatment, and 30–60 days after discharge. Frequencies were categorized as Low (1, 1.5, 2 kHz), Mid (3, 4, 5 kHz), Mid-high (6, 7, 8 kHz), and High (9, 10 kHz). Pure Tone Audiometry (PTA3) was performed at discharge and 60 days after. Patients were treated with i.v. ceftriaxone or oral doxycycline for 14 days according to guidelines. DPOAE measurements were obtained in 25 patients with LNB at admission and in 18 patients at follow-up. Median age was 56 years (IQR, 48–64 years), and 16 (67%) were men. Fourteen (78%) of 18 patients showed improvement in Emission Threshold Levels (ETL) from admission to follow-up in low, mid-, and mid-high frequency categories, where ETLs increased by median levels of 3.2 (−4.1 to 8.3), 7.5 (−2.8 to 9.8), and 4.7 dB (−4.3 to 10.1). A decline was observed in the high frequency category, median −3.3 dB (−9.1 to 6.7). SNHL defined by pure tone average (PTA3) >20 dB was present in 11 out of 23 (48%) at discharge and in 9 out of 16 patients (56%) 60 days after discharge, which differed significantly from matched controls (Mann-Whitney test, p = 0.036). LNB can lead to cochlear outer-hair cell dysfunction, resulting in temporary and long-term SNHL.
Trigonopterus Fauvel 1862
Creators: name: Riedel, Alexander
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Trigonopterus

description: Trigonopterus Fauvel 1862
Type-species: Trigonopterus insignis Fauvel, 1862, by monotypy.
Diagnosis. Fully apterous genus of Cryptorhynchinae. Length 1.5–6.0 mm. Rostrum in repose not reaching center of mesocoxa. Scutellum completely absent externally. Mesothoracic receptacle deep, posteriorly closed. Metanepisternum completely absent. Elytra with 9 striae (sometimes superficially effaced). Tarsal claws minute. Usually body largely unclothed, without dense vestiture.
description: Published as part of Riedel, Alexander, 2010, One of a thousand - a new species of Trigonopterus (Coleoptera, Curculionidae, Cryptorhynchinae) from New Guinea, pp. 59-68 in Zootaxa 2403 on page 60, DOI: 10.5281/zenodo.293314
Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis
Creators: name: Huang, Yanping
name: Flentke, George R
name: Smith, Susan M
Publisher: name: Elsevier
Year: 2024

description:
Prenatal alcohol exposure is a leading cause of permanent neurodevelopmental disability and can feature distinctive craniofacial deficits that partly originate from the apoptotic deletion of craniofacial progenitors, a stem cell lineage called the neural crest (NC). We recently demonstrated that alcohol causes nucleolar stress in NC through its suppression of ribosome biogenesis (RBG) and this suppression is causative in their p53/MDM2-mediated apoptosis. Here, we show that this nucleolar stress originates from alcohol's activation of AMPK, which suppresses TORC1 and the p70/S6K-mediated stimulation of RBG. Alcohol-exposed cells of the pluripotent, primary cranial NC line O9-1 were evaluated with respect to their S6K, TORC1, and AMPK activity. The functional impact of these signals with respect to RBG, p53, and apoptosis were assessed using gain-of-function constructs and small molecule mediators. Alcohol rapidly (<2 hr) increased pAMPK, pTSC2, and pRaptor, and reduced both total and pS6K in NC cells. These changes persisted for at least 12 hr to 18 hr following alcohol exposure. Attenuation of these signals via gain- or loss-of-function approaches that targeted AMPK, S6K, or TORC1 prevented alcohol's suppression of rRNA synthesis and the induction of p53-stimulated apoptosis. We conclude that alcohol induces ribosome dysbiogenesis and activates their p53/MDM2-mediated apoptosis via its activation of pAMPK, which in turn activates TSC2 and Raptor to suppress the TORC1/S6K-mediated promotion of ribosome biogenesis. This represents a novel mechanism underlying alcohol's neurotoxicity and is consistent with findings that TORC1/S6K networks are critical for cranial NC survival.
Temnothorax alpinus
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax alpinus

description: 116. T. alpinus (Ruzsky, 1902)
Distribution: W.G.: Mamisoni Pass (Ruzsky, 1905); E.G.: Gudauri (Ruzsky, 1905).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
Temnothorax brauneri
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax brauneri

description: 117. T. brauneri (Ruzsky, 1905)
Distribution: W.G.: Baghdati, Surebi (Ruzsky, 1905); S.G.: Zekari Pass (Ruzsky, 1905).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
Frequency importance for sentence recognition in co-located noise, co-located speech, and spatially separated speech
Creators: name: Calandruccio, Lauren
name: Buss, Emily
name: Wasiuk, Peter A.
name: Bosen, Adam K.
Publisher: name: Acoustical Society of America (ASA)
Year: 2024

description:
Frequency importance functions quantify the contribution of spectral frequencies to perception. Frequency importance has been well-characterized for speech recognition in quiet and steady-state noise. However, it is currently unknown whether frequency importance estimates generalize to more complex conditions such as listening in a multi-talker masker or when targets and maskers are spatially separated. Here, frequency importance was estimated by quantifying associations between local target-to-masker ratios at the output of an auditory filterbank and keyword recognition accuracy for sentences. Unlike traditional methods used to measure frequency importance, this technique estimates frequency importance without modifying the acoustic properties of the target or masker. Frequency importance was compared across sentences in noise and a two-talker masker, as well as sentences in a two-talker masker that was either co-located with or spatially separated from the target. Results indicate that frequency importance depends on masker type and spatial configuration. Frequencies above 5 kHz had lower importance and frequencies between 600 and 1900 Hz had higher importance in the presence of a two-talker masker relative to a noise masker. Spatial separation increased the importance of frequencies between 600 Hz and 5 kHz. Thus, frequency importance functions vary across listening conditions.
Vanderhorstia prochazkai Schwarzhans 2020
Creators: name: Schwarzhans, Werner
name: Klots, Oleksandr
name: Ryabokon, Tamara
name: Kovalchuk, Oleksandr
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gobiidae
Vanderhorstia
Vanderhorstia prochazkai

description: Vanderhorstia prochazkaiSchwarzhans et al.,2020a,
2020b
Figure 6h–j
2020a Vanderhorstia prochazkai —Schwarzhans, Brzobohatý & Radwańska: pl. 7, figs. 12–18.
Material 6 otoliths: 1 specimen, Kozatskyi Yar, NMNHU- P PI 2581; 2 specimens, Mlyntsi, NMB P1223; 3 specimens, Shydlivshchyna, NMNHU-P PI 2582.
Discussion Tese are typical high-bodied and rather thick otoliths of V. prochazkai that are further characterized by a very large subcaudal iugum. Vanderhorstia prochazkai has been described from the late Badenian and early Sarmatian s.s. of the Central Paratethys by Schwarzhans et. al. (2020a). Today, species of the Asterropteryx Lineage live commensal with alpheid shrimps, and it has been suggested that this was also the case in the middle Miocene (Radwańska, 2018; Schwarzhans et al., 2020a).
Vanderhorstia sp.
Figure 6k
Material 2 otoliths, Shydlivshchyna, NMNHU-P PI 2583 and NMB P1224.
Discussion Two specimens differ from V. prochazkai in being distinctly thinner (OH:OT = 3.45 vs. mostly 3.0– 3.3, rarely 3.5) and in showing a narrow subcaudal iugum. It may represent a second species, but the available specimens are not sufficiently well-preserved for a definite assessment.
description: Published as part of Schwarzhans, Werner, Klots, Oleksandr, Ryabokon, Tamara & Kovalchuk, Oleksandr, 2022, A rare window into a back-reef fish community from the middle Miocene (late Badenian) Medobory Hills barrier reef in western Ukraine, reconstructed mostly by means of otoliths, pp. 1-35 in Swiss Journal of Palaeontology (18) (18) 141 (1) on page 17, DOI: 10.1186/s13358-022-00261-3, http://zenodo.org/record/11999827
Polydora Fenzl
Creators: name: Swelankomo, N.
name: Simango, N.
name: Manning, J. C.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Polydora

description: Polydora Fenzl in Flora 27: 312 (1844).
Type: Polydora stoechadifolia Fenzl
Crystallopollen Steetz in Peters, Reise Mossamb. Bot.: 363 (1864).
Type: Crystallopollen angustifolium Steetz = Polydora angustifolia (Steetz) H.Rob.
Mostly annual (rarely perennial) herbs, stem and leaves with L- or asymmetrically T-shaped hairs with short multicellular stem and elongate-attenuate, one-armed cap-cell. Leaves alternate, narrow. Capitula discoid, either solitary and terminal, or in a thyrsoid panicle with corymbose branches. Involucre campanulate; involucral bracts in ±6 or 7 series, imbricate, lanceolate, usually apiculate or mucronte, often with scarious margins, ± pubescent, often black or purple at tips; receptacle epaleate. Florets ± 30 per capitulum, corollas lilac or mauve to purplish; corolla tube long, narrowly funnel-shaped, lobes linear-attenuate, glabrous. Anthers ecaudate, with glabrous apical appendage. Style branches with needle-like sweeping hairs. Cypselas narrowly obconic-turbinate, 5- to 12- ribbed, setose on ribs with twin hairs scarcely divided apically, and gland-dotted between ribs; pappus biseriate, outer series of small fimbriate scales, inner series of barbellate bristles. Pollen lophate and pantoporate (with more than five pores).
The genus includes a handful of species from tropical, subtropical and southern Africa. Species limits in the group are still unclear, and the number of species is likely to be fewer than currently recognised.
description: Published as part of Swelankomo, N., Simango, N. & Manning, J. C., 2018, The genus Polydora Fenzl (Asteraceae: Vernonieae) in southern Africa *, pp. 335-339 in South African Journal of Botany 119 on page 336, DOI: 10.1016/j.sajb.2018.10.002, http://zenodo.org/record/10496560
Sexual health in an aging world: a global call to action for more resilient services for older and disabled adults
Creators: name: Randazzo, Sophia
name: Wu, Dan
name: Gonsalves, Lianne
name: Kritzer, Isabella
name: Zou, Huachun
name: Conyers, Hayley
name: Sakuma, Yoshiko
name: Day, Suzanne
name: Kpokiri, Eneyi E
name: Tucker, Joseph D
Publisher: name: CSIRO Publishing
Year: 2024

description:
Sexual health and well-being are critical for people across all age groups. However, older adults are neglected in sexual health research, programs, and policies. This editorial is a call to action for greater attention to the sexual health of older adults. We welcome all related research on this topic, but are particularly interested in manuscripts related to sexual functioning and co-morbidities, menopause and related topics, sexual health service utilization, research that links sexual activity and health, perspectives from low and middle-income countries, and community-engaged research on sexual health among older adults.
Temnothorax corticalis
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax corticalis

description: 118. T. corticalis (Schenck, 1852)
Distribution: S.G.: Baniskhevi, Mzetamze, Tsaghveri (Jijilashvili, 1997a).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
Efficacy of angiotensin receptor blockers for nocturnal blood pressure reduction: a systematic review and meta-analysis
Creators: name: Liu, Jing
name: Chen, Wei
name: Shao, Shihuan
name: Chen, Yuanyuan
name: Wang, Hongyi
name: Xi, Yang
name: Wang, Luyan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Nocturnal blood pressure (BP) is correlated with an increased risk of cardiovascular events and is an important predictor of cardiovascular death in hypertensive patients. Nocturnal BP control is of great importance for cardiovascular risk reduction. This systematic review and meta-analysis aimed to explore the efficacy of angiotensin receptor blockers (ARBs) for nocturnal BP reduction in patients with mild to moderate hypertension. PICOS design structure was used to formulate the data extraction. All statistical calculations and analyses were performed with R. Seventy-seven studies with 13,314 participants were included. The overall analysis indicated that nocturnal BP drop varied considerably among different ARBs. Allisartan (13.04 [95% CI (−18.41, −7.68)] mmHg), olmesartan (11.67 [95% CI (−14.12, −9.21)] mmHg), telmisartan (11.11 [95% CI (−12.12, −10.11)] mmHg) were associated with greater reduction in nocturnal systolic BP. In the aspect of the nocturnal-diurnal BP drop ratio, only allisartan was greater than 1. While, the variation tendency of last 4–6 h ambulatory BP was basically consistent with nocturnal BP. Additionally, allisartan showed improvement effect in the proportion of patients with dipping BP pattern. This study demonstrates that for patients with mild to moderate hypertension, allisartan, olmesartan and telmisartan have more advantages in nocturnal BP reduction among the ARBs, while allisartan can reduce nighttime BP more than daytime BP and improve the dipping pattern. This meta-analysis explores the efficacy of Angiotensin II AT1 receptor antagonists (ARBs) on nocturnal blood pressure (BP) reduction in mild to moderate hypertension.The results demonstrate that for patients with mild to moderate hypertension, allisartan, olmesartan and telmisartan have more advantages in nocturnal BP reduction among the ARBs.Allisartan can reduce nighttime BP more effectively than daytime BP, which also improve the dipping pattern. This meta-analysis explores the efficacy of Angiotensin II AT1 receptor antagonists (ARBs) on nocturnal blood pressure (BP) reduction in mild to moderate hypertension. The results demonstrate that for patients with mild to moderate hypertension, allisartan, olmesartan and telmisartan have more advantages in nocturnal BP reduction among the ARBs. Allisartan can reduce nighttime BP more effectively than daytime BP, which also improve the dipping pattern.
Assessment of Health Disparities and Sexual Orientation Response Choices Used in Two US National Population-Based Health Surveys, 2020‒2021.
Creators: name: Hernandez, Stephanie M
name: Kahn, Nicole F
name: Halpern, Carolyn T
name: Conron, Kerith J
name: Burshell, Dana R
Publisher: name: American Public Health Association
Year: 2024

description:
Objectives. To (1) compare responses to 2 survey questions designed to measure sexual orientation and (2) understand how variation in responses is associated with mental health. Methods. Data were from the National Longitudinal Study of Adolescent to Adult Health (Add Health) Sexual Orientation/Gender Identity, Socioeconomic Status, and Health Across the Life Course (SOGI-SES) study (2020-2021) in the United States. We used the adjusted Wald test to compare proportions of respondents who were (1) categorized as heterosexual or straight and sexual minorities using the sexual orientation questions designed for the Add Health study and the National Health Interview Survey (NHIS) and (2) diagnosed with depression or anxiety or panic disorder. Results. The Add Health question detected more than twice as many sexual minority respondents as the NHIS question. Those who responded as sexual minorities to the Add Health question but as heterosexual or straight to the NHIS question, primarily "mostly heterosexuals," had mental health outcomes that were more like those who were consistently classified as sexual minorities versus those consistently classified as heterosexual or straight. Conclusions. Current measures of sexual orientation in national-level surveys may underestimate the sexual minority population and sexual orientation‒related health disparities. Public Health Implications. Results illustrate the need for further research to expand measurement of sexual orientation on population-based health surveys. (Am J Public Health. 2024;114(12):1375-1383. https://doi.org/10.2105/AJPH.2024.307839).
Temnothorax exilis
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax exilis

description: 119. T. exilis (Emery, 1869)
Distribution: E.G.: Manglisi, Pasanauri (Ruzsky, 1905).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
An mpox quadrivalent mRNA vaccine elicits sustained and protective immunity in mice against lethal vaccinia virus challenge
Creators: name: Li, Entao
name: Yang, Qiyuan
name: Xie, Wenyu
name: Gong, Qizan
name: Guo, Xiaoping
name: Zhou, Jinge
name: Zhang, Jiachen
name: Chuai, Xia
name: Wang, Yucai
name: Chiu, Sandra
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Assessing the long-term efficacy of MPXV vaccine candidates is crucial for the global response to the ongoing mpox epidemic. Built upon our previous study of the mpox quadrivalent mRNA vaccine, herein we reported that MPXV-1103 could elicit sustained humoral and cellular immunity in mice, including the induction of MPXV A35/B6/A29/M1-specific IgG antibodies, VACV neutralizing antibodies and activated cytotoxic CD8+T cells, which provides 100% protection against lethal VACV challenge even at 280 days after the first vaccination. Our results provide critical insights for orthopoxvirus vaccine development.
Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species
Creators: name: Daigle, Austin
name: Johri, Parul
Publisher: name: Oxford University Press (OUP)
Year: 2024

description:
The accurate estimation of the distribution of fitness effects (DFE) of new mutations is critical for population genetic inference but remains a challenging task. While various methods have been developed for DFE inference using the site frequency spectrum of putatively neutral and selected sites, their applicability in species with diverse life history traits and complex demographic scenarios is not well understood. Selfing is common among eukaryotic species and can lead to decreased effective recombination rates, increasing the effects of selection at linked sites, including interference between selected alleles. We employ forward simulations to investigate the limitations of current DFE estimation approaches in the presence of selfing and other model violations, such as linkage, departures from semidominance, population structure, and uneven sampling. We find that distortions of the site frequency spectrum due to Hill-Robertson interference in highly selfing populations lead to mis-inference of the deleterious DFE of new mutations. Specifically, when inferring the distribution of selection coefficients, there is an overestimation of nearly neutral and strongly deleterious mutations and an underestimation of mildly deleterious mutations when interference between selected alleles is pervasive. In addition, the presence of cryptic population structure with low rates of migration and uneven sampling across subpopulations leads to the false inference of a deleterious DFE skewed towards effectively neutral/mildly deleterious mutations. Finally, the proportion of adaptive substitutions estimated at high rates of selfing is substantially overestimated. Our observations apply broadly to species and genomic regions with little/no recombination and where interference might be pervasive.
Temnothorax korbi
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax korbi

description: 120. T. korbi (Emery, 1924)
Distribution: E.G.: Karsani, Kojori, Nichbisi, surroundings of Gokhnari, Tbilisi (Mtatsminda Park, Tbilisi Botanical Garden), Tetritskaro (Jijilashvili, 1968, 1973, 1974a); S.G.: Tskhratskaro (Jijilashvili, 1974a).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
Contraception Choice Beyond Efficacy
Creators: name: Wilkinson, Tracey A.
name: Hoopes, Andrea J.
name: Allison, Bianca A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2025

description:
To the Editor We were excited to see the recent patient-facing
publication entitled “What Teens Should Know About Choosing
Contraception” by Gray and Thompson.
Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion
Creators: name: Liu, Xinpeng
name: Huang, Lan
name: Ye, Yang
name: Wang, Haiyi
name: Tang, Min
name: He, Fuqiang
name: Xia, Zijing
name: Deng, Shi
name: Zhang, Peng
name: Dai, Ruiwu
name: Liang, Shufang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The resistance of commonly used clinical antibiotics, such as daptomycin (DAP), has become increasingly serious in the fight against Staphylococcus aureus (S. aureus) infection. It is essential to explore key pathogenicity-driven genes/proteins in bacterial infection and antibiotics resistance, which contributes to develop novel therapeutic strategies against S. aureus infections. The nt5 gene of S. aureus, encoding 5’-nucleotidase (NT5), is nearly unknown for its function in drug resistance and bacterial infection. Herein, to reveal nt5 gene role in drug resistance and infection ability of S. aureus, we performed nt5C166T gene mutation using a clustered regulatory interspaced short palindromic repeat ribonucleic acid (RNA)-guided base editing system to investigate the lose-of-function of NT5 protein. Subsequent transcriptome sequencing of the mutant strain revealed that nt5 inactivation caused changes in cell membrane integrity and inhibited nucleotide metabolism, suggesting the nt5 gene may be involved in bacterial drug resistance and virulence. The mutant strain exhibited enhanced tolerance to DAP treatment by attenuating cell membrane potential dissipation and slowing deoxyribonucleic acid release. Moreover, the nt5 mutation alleviated abscess degree of mouse kidneys caused by S. aureus infection byreducing the expression of IL-1β, IL-6, and IL-18. The nt5 mutant strain was easily swallowed by host immune cells, resulting in weak bacterial toxicity of the S. aureus mutant in the bacterial infection process. In summary, nt5 gene mutation confers tolerance to DAP and a lower bacterial capacity to form kidney abscesses through phagocytosis of host immune cells, which indicates the targeted inhibition of NT5 protein would offer a potential new therapeutic strategy against S. aureus infection.
Hypercontact semilattices
Creators: name: Lipparini, Paolo
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Boolean algebras are one of the main algebraic tools in the region-based theory of space. T. Ivanova provided strong motivations for the study of mere semilattices with a contact relation. Another significant motivation for considering an even weaker underlying structure comes from event structures with binary conflict in the theory of concurrent systems in computer science. All the above-hinted notions deal with a binary contact relation. Several authors suggested the more general study of n-ary ‘hypercontact’ relations. A similar evolution occurred in the study of the just mentioned event structures in computer science. To unify the above lines of research, in this paper, we study joining semilattices with a hypercontact relation. We provide representation theorems into Boolean algebras. With a single exception, our proofs are choice-free. We also present several examples and problems; in particular, we briefly discuss some connections with event structures and hypergraphs.
Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis
Creators: name: Wu, Tsai-Shan
name: Wu, Ping-Hsun
name: Lin, Hsiu-Fen
name: Chen, Wen-Ching
name: Huang, Teng-Hui
name: Lin, Ming-Yen
name: Chuang, Yun-Shiuan
name: Yang, Fan-Pei Gloria
name: Chiu, Yi-Wen
name: Chang, Jer-Ming
name: Kuo, Mei-Chuan
name: Lin, Yi-Ting
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Mental Health

description: Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive performance. Therefore, this study investigated the associations between the mini-mental status examination (MMSE), Montreal cognitive assessment (MoCA), cognitive abilities screening instrument (CASI), and Fazekas scale in patients under hemodialysis (HD). The periventricular (PV) WMHs and deep WMHs (DWMHs) in brain magnetic resonance images of 59 patients under dialysis were graded using the Fazekas scale. Three cognition function tests were also performed, then multivariable ordinal regression and logistic regression were used to identify the associations between cognitive performance and the Fazekas scale. There were inverse associations between the three cognitive function tests across the Fazekas scale of PVWMHs (p = .037, .006, and .008 for MMSE, MoCA, and CASI, respectively), but the associations were attenuated in the DWMHs group. In CASI, significant differences were identified in short-term memory, mental manipulation, abstract thinking, language, spatial construction, and name fluency in the PVWMHs group. However, DWMHs were only significantly correlated with abstract thinking and short-term memory. An inverse correlation existed between the Fazekas scale, predominantly in PVWMHs, and cognition in patients undergoing HD. The PVWMHs were associated with cognitive performance assessed by MMSE, MoCA, and CASI, as well as with subdomains of CASI such as memory, language and name fluency in patients undergoing HD. An inverse correlation existed between the Fazekas scale and cognition in patients undergoing hemodialysis, predominantly in periventricular white matter hyperintensities. The periventricular white matter hyperintensities were associated with cognitive performance assessed by mini-mental status examination (MMSE), Montreal cognitive assessment (MoCA), cognitive abilities screening instrument (CASI), as well as with subdomains of CASI such as memory, language and name fluency in patients undergoing HD.
Temnothorax melnikovi
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax melnikovi

description: 121. T. melnikovi (Ruzsky, 1905)
Distribution: S.G.: Akhaltsikhe, Sapara (Jijilashvili, 1974a).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
A Novel Spatio-temporal Hub Identification in Brain Networks by Learning Dynamic Graph Embedding on Grassmannian Manifolds
Creators: name: Chen, Minghan
name: Shen, Hui
name: Yang, Defu
name: Wang, Shuai
name: Chen, Jiazhou
name: Chen, Xueli
name: Wu, Guorong
name: Zhu, Wentao
name: Cai, Hongmin
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2024

description:
Mounting evidence has revealed that functional brain networks are intrinsically dynamic, undergoing changes over time, even in the rest-state environment. Notably, recent studies have highlighted the existence of a small number of critical brain regions within each functional brain network that exhibit a flexible role in adapting the geometric pattern of brain connectivity over time, referred to as "temporal hub" regions. Therefore, the identification of these temporal hubs becomes pivotal for comprehending the mechanisms that underlie the dynamic evolution of brain connectivity. However, existing spatio-temporal hub identification methods rely on static network-based approaches, wherein each temporal hub region is independently inferred from individual time-segmented networks without considering their temporal consistency and consequently fails to align the evolution of hubs with the dynamic changes in brain states. To address this limitation, we propose a novel spatio-temporal hub identification method that fully leverages dynamic graph embedding to distinguish temporal hubs from peripheral nodes, in which dynamic graph embeddings are learned from both spatial and temporal dimensions. Specifically, to preserve the temporal consistency of evolving networks, we model the dynamic graph embedding as a physical model of time, where the network-to-network transition is mathematically expressed as a total variation of dynamic graph embedding with respect to time. Furthermore, a Grassmannian manifold optimization scheme is introduced to enhance graph embedding learning and capture the time-varying topology of brain networks. Experimental results on both synthetic and real fMRI data demonstrate superior temporal consistency in hub identification, surpassing conventional approaches.
Temnothorax nadigi
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax nadigi

description: 122. T. nadigi (Kutter, 1925)
Syn.: Leptothorax caucasicus Arn.
Distribution: E.G.: Kojori (Arnol'di, 1977).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 142
A giant planet transiting a 3-Myr protostar with a misaligned disk
Creators: name: Shporer, Avi
name: Andrews, Sean M.
name: Lopez Murillo, Ana Isabel
name: Espaillat, Catherine
name: Seager, Sara
name: Rodriguez, David R.
name: Pearce, Logan
name: Feinstein, Adina D.
name: Boyle, Andrew W.
name: Palle, Enric
name: Jenkins, Jon M.
name: Ansdell, Megan
name: Krolikowski, Daniel
name: Murgas, Felipe
name: Fields, Matthew
name: Tofflemire, Benjamin M.
name: Thao, Pa Chia
name: Winn, Joshua N.
name: Barber, Madyson G.
name: Dragomir, Diana
name: Latham, David W.
name: Kraus, Adam
name: Sawczynec, Erica
name: Mace, Gregory N.
name: Collins, Karen A.
name: Schwarz, Richard P.
name: Villaseñor, Jesus Noel
name: Essack, Zahra
name: Jaffe, Daniel
name: De Furio, Matthew
name: Mann, Andrew W.
name: Newton, Elisabeth R.
name: Watkins, Cristilyn N.
name: Vanderburg, Andrew
name: Vanderspek, Roland
name: Twicken, Joseph D.
name: Ricker, George
name: Charbonneau, David
Publisher: name: Springer Nature
Year: 2024

description:
Astronomers have found more than a dozen planets transiting stars that are 10–40 million years old1, but younger transiting planets have remained elusive. The lack of such discoveries may be because planets have not fully formed at this age or because our view is blocked by the protoplanetary disk. However, we now know that many outer disks are warped or broken2; provided the inner disk is depleted, transiting planets may thus be visible. Here we report observations of the transiting planet IRAS 04125+2902 b orbiting a 3-million-year-old, 0.7-solar-mass, pre-main-sequence star in the Taurus Molecular Cloud. The host star harbours a nearly face-on (30 degrees inclination) transitional disk3 and a wide binary companion. The planet has a period of 8.83 days, a radius of 10.7 Earth radii (0.96 Jupiter radii) and a 95%-confidence upper limit on its mass of 90 Earth masses (0.3 Jupiter masses) from radial-velocity measurements, making it a possible precursor of the super-Earths and sub-Neptunes frequently found around main-sequence stars. The rotational broadening of the star and the orbit of the wide (4 arcseconds, 635 astronomical units) companion are both consistent with edge-on orientations. Thus, all components of the system are consistent with alignment except the outer disk; the origin of this misalignment is unclear.
Microlaimus de Man 1880
Creators: name: Revkova, Tatiana N.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Adenophorea
Desmodorida
Microlaimidae
Microlaimus

description: Genus Microlaimus de Man, 1880
Diagnosis. (modified from Tchesunov, 2014) Cuticle annulated, in some species also showing punctations or lon- gitudinal bars. Head slightly set off. Spicules usually short and arcuate, seldom long and slender; gubernaculum present, often bent distally but without dorso-caudal apophyses. Papilloid precloacal supplements may be present. Ovaries paired, outstretched.
Type species: M. globiceps de Man, 1880
description: Published as part of Revkova, Tatiana N., 2020, A new species of Microlaimus de Man 1880 (Nematoda: Microlaimidae) from the Black Sea, pp. 183-188 in Zootaxa 4772 (1) on page 184, DOI: 10.11646/zootaxa.4772.1.6, http://zenodo.org/record/3813977
Temnothorax nigriceps
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax nigriceps

description: 123. T. nigriceps (Mayr, 1855)
Distribution: E.G.: Manglisi (Ruzsky, 1905).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 143
Barcoding of viable peripheral blood mononuclear cells with selenium and tellurium isotopes for mass cytometry experiments
Creators: name: McKinnon, Karen
name: Flick, Leah M.
name: Iannone, Marie A.
name: Withers, Tracy A.
name: Savoldo, Barbara
name: Fowler, Ken
name: Seo, Youngran
Publisher: name: Wiley
Year: 2024

description:
Barcoding viable cells combined with pooled sample staining is an effective technique that eliminates batch effects from serial cell staining and facilitates uninterrupted data acquisition. We describe three novel and isotopically pure selenium-containing compounds (SeMals) that are useful cellular labeling tools. The maleimide-functionalized selenophenes (76SeMal, 77SeMal, and 78SeMal) covalently react with cellular sulfhydryl groups and uniquely label cell samples. The SeMal reagents label viable and paraformaldehyde-fixed peripheral blood mononuclear cells (PBMC), are well resolved by the mass cytometer, and have little spill into adjacent channels. They appear non-toxic to viable cells at working concentrations. We used SeMal reagents in combination with four isotopically pure tellurium maleimide reagents (124TeMal, 126TeMal, 128TeMal, and 130TeMal) to label 21 individual PBMC samples with unique combinations of selenium and tellurium isotopes (seven donors with three replicates using a 7 isotope pick 2 combinatorial schema). The individually barcoded samples were pooled, stained with an antibody cocktail as a pool, and acquired on the mass cytometer as a single suspension. The single-cell data were de-barcoded into separate sample-specific files after data acquisition, enabling an uninterrupted instrument run. Each donor sample retained its unique phenotypic profile with excellent replicate reproducibility. Unlike current live cell barcoding methods, this approach does not require antibodies to surface markers, allowing for the labeling of all cells regardless of surface antigen expression. Additionally, since selenium and tellurium isotopes are not currently utilized in CyTOF antibody panels, this method expands barcoding options and frees up commonly used isotopes for more detailed cell profiling.
Research progress of megakaryocytes and platelets in lung injury
Creators: name: Hua, Tianzhen
name: Zhang, Guangliang
name: Yao, Yi
name: Jia, Haoran
name: Liu, Wei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: The lung is an important site of extramedullary platelet formation, and megakaryocytes in the lung participate in immune responses in addition to platelet production. In acute lung injury and chronic lung injury, megakaryocytes and platelets play a promoting or protective role through different mechanisms. The authors reviewed the role of megakaryocytes and platelets in common clinical lung injuries with different course of disease and different pathogenic factors in order to provide new thinking for the diagnosis and treatment of lung injuries. What is the context? Platelets are specialized non-nucleated blood cells produced by cytoplasmic lysis of megakaryocytes. HSCs differentiate into granular mature megakaryocytes and produce platelets. Lung is a reservoir of megakaryocytes and a site where platelets are produced in addition to bone marrow and spleen. Lung injury can be divided into acute lung injury and chronic lung injury, and characterized by different pathogenesis. Platelets and megakaryocytes are involved in hemostasis and regulation of the body ‘s inflammatory response. The disease state of the lung affects the functions of megakaryocytes and platelets. The role of megakaryocytes and platelets in acute and chronic lung injury is poorly studied. What is new? Platelets in the lung are derived not only from the spleen and bone marrow, but also from megakaryocytes in the pulmonary circulation. In this study, we demonstrated that pulmonary megakaryocytes not only produce platelets to play a hemostatic role in lung injury, but also participate in inflammation and immune response with platelets to promote the process of lung injury or play a protective role. Therefore, it was suggested in our analysis that targeting lung megakaryocytes and platelets is currently a new direction for the treatment of a variety of lung injuries. What is the impact? This review intends to explain the relationship between megakaryocytes, platelets and many types of lung injury from the mechanism of platelet production in the lung, and make a prospect in the new progress in the diagnosis and treatment of lung injury.
Titlatehtemozceh huan titlayoltilizceh ica tomacehualtlahtol huan tomacehualtlallamicca: ¿queniuhqui titequitizceh?
Creators: name: de la Cruz, Abelardo
Publisher: name: Wiley
Year: 2024

description:
Ipan cempohualli hueyixihuicahuitl huan naman tonatiuh coyomeh tlen zancapahueli tlalli quichiuhtihualtoqueh tlatehtemoliztli zan ica inintlallamiquiliz campa moixnextihtihualtoc nahuatlahtolli huan macehualtlallamiccayotl. Pan ni amatlahcuilolli nizaniloa queniuhqui macehualmeh tlen naman tiquittah inintequiuh coyomeh tlatehtemoanih tlen tlahcuiloah ica macehualtlallamiccayotl, huan nouhquiya niquihtoa tlen monequi ticchihuazceh macehualmeh tlen Mexcotlalli pan tlatehtemoliztequitl tlen ica titlahtolyoltilizceh nahuatlahtolli. Nouhquiya nizaniloa ica quizaliztli campa ticcauhtehuah toaltepehuan huan quichihua ma tizanilocan ceyoc tlahtolli huan pehuah timoixpatlah. Ica totlamachtiliz tlen ticcuitoqueh naman, nizaniloa ica ce yancuic ohtli campa ticchihuazceh tlatehtemoliztli pan toaltepehuan. Na niquitta quemman macehualmeh ticchihuah ce tequitlatehtemoliztli, achtohui ticcalaquih tiquixmatih tomacehualtlallamicca ica toyoltlallamiquiliz campa timochomoniah ica tlahtolyoltiliztli. Temachtli ticchihuah tequitl ica totlahtol campa tictequihuiah tonantlahtol huan teipan ticpannextiah macehualtlamatiliztli ipan caltlamachtiloyan huan nouhquiya ipan toaltepehuan.
Causes of death and trends in mortality from the year 2000 to 2017 in patients with acute myocardial infarction
Creators: name: Scharlach, David
name: Schmitz, Timo
name: Raake, Philip
name: Linseisen, Jakob
name: Meisinger, Christa
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: To investigate the most common causes of death and trends in cause-specific long-term mortality in patients hospitalized for acute myocardial infarction (AMI). This analysis was based on 10,718 patients, aged 25–74 years, recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. All hospitalized cases of AMI occurring in the study region during this period were included. If a patient died during follow-up (median: 6.6 years, IQR: 2.8–11.2) the death certificate was obtained and coded using the ICD-10 to determine the main cause of death. Cause-specific mortality was calculated for three 6-year periods. Multivariable adjusted Cox regression models stratified by time interval were calculated. The most common cause of death was cardiovascular disease (CVD), more precisely ischemic-heart disease (IHD), followed by cancer. The proportions of CVD deaths and IHD deaths were stable over time. An increasing trend was observed in cancer mortality in post-AMI patients. In male patients, the hazard ratio for cancer mortality was 44.4% higher in 2012–2017 compared to 2000–2005, in female patients, it was more than twice as high in 2006–2012 compared to 2000–2005. This study revealed consistent CVD and IHD long-term mortality and increasing trends in long-term cancer mortality in patients post-AMI. Thus, post-AMI patients should emphasize tertiary prevention of CVD by minimizing risk factors. Furthermore, patients should regularly undergo cancer screening programs. The reasons for the unfavorable development in terms of increasing cancer mortality should be investigated in further studies.
Revealing Long-Range Order in Brush-like Graft Copolymers Through In Situ Measurements of X-Ray Scattering During Deformation
Creators: name: Piryazev, Alexey A.
name: Umarov, Akmal Z.
name: Sheiko, Sergei S.
name: Gordievskaya, Yulia D.
name: Ivanov, Dimitri A.
name: Moutsios, Ioannis
name: Nikitina, Evgeniia A.
name: Kurbatov, Andrey O.
name: Maw, Mitchell R.
name: Dashtimoghadam, Erfan
name: Kramarenko, Elena Yu.
name: Rosenthal, Martin
Publisher: name: MDPI
Year: 2024

description:
Brush-like graft copolymers (A-g-B), in which linear A-blocks are randomly grafted onto the backbone of a brush-like B-block, exhibit intense strain-stiffening and high mechanical strength on par with load-bearing biological tissues such as skin and blood vessels. To elucidate molecular mechanisms underlying this tissue-mimetic behavior, in situ synchrotron X-ray scattering was measured during uniaxial stretching of bottlebrush- and comb-like graft copolymers with varying densities of poly(dimethyl siloxane) and poly(isobutylene) side chains. In an undeformed state, these copolymers revealed a single interference peak corresponding to the average spacing between the domains of linear A-blocks arranged in a disordered, liquid-like configuration. Under uniaxial stretching, the emergence of a distinct four-spot pattern in the small-angle region indicated the development of long-range order within the material. According to the affine deformation of a cubic lattice, the four-spot pattern’s interference maxima correspond to 110 reflections upon stretching along the [111] axis of the body-centered unit cell. The experimental findings were corroborated by computer simulations of dissipative particle dynamics that confirmed the formation of a bcc domain structure.
Temnothorax nigritus
Creators: name: Gratiashvili, N.
name: Barjadze, S.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Temnothorax
Temnothorax nigritus

description: 124. T. nigritus (Emery, 1878)
Distribution: W.G.: Batumi, Kutaisi, Oni (Ruzsky, 1905); S.G.: Zekari Pass (Ruzsky, 1905).
description: Published as part of Gratiashvili, N. & Barjadze, S., 2008, Checklist of the ants (Formicidae Latreille, 1809) of Georgia., pp. 130-146 in Proceedings of the Institute of Zoology 23 on page 143