cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Odyssey : a computer program to access medical knowledge
Creators: name: Fan, Chin-Li
Publisher: name: University of Utah
Year: 2012

description: Odyssey is a part of a software package of computing tools designed to aid the third year medical students at the University of Utah while they are on the Internal Medicine clerkship.  The Odyssey program is designed to facilitate students' access to selected knowledge bases of high clinical relevance.  This thesis describes the experience of adapting the Help's (Health Evaluation through Logic Processing) knowledge base and clinical patient data base as a teaching tool.  Odyssey is a free format database management system built on the Macintosh computer.  Odyssey manages a HELP knowledge database and a literature database, using a concept called relations to facilitate data retrieval.  Communication between the Macintosh and Tandem mainframe has been established to let students explore the HELP system through a Macintosh computer.  A relation file can be created to hierarchically group medical concepts together to facilitate the data retrieval.
Cyclocephala modesta Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala modesta

description: § Cyclocephala modesta Burmeister, 1847
Cyclocephala modesta Burmeister 1847: 38 (Brazil - LECTOTYPE)
Distribution. Suriname: Endrödi 1966a: 260; Moore et al. 2018b: 215. French Guiana: Duranton 2011: 14 (?). Brazil: Burmeister 1847: 38; Arrow 1937b: 13; Blackwelder 1944: 252; Endrödi 1966a: 260 (designation LECTOTYPE Cyclocephala modesta); Moore et al. 2018b: 215. Other: Blackwelder 1944: 252 (Argentina); Endrödi 1966a: 260 (Argentina, Bolivia, Paraguay, Uruguay), 1985a: 43, 118 (tropical South America); Ponchel 2011 (not mentioned); Dupuis 2016b (not mentioned); Moore et al. 2018b: 215 (Argentina, Bolivia, Chile, Paraguay, Uruguay).
Note. Endrödi (1966a: 260) records Cyclocephala modesta for Suriname and this record is repeated in Moore et al. (2018b: 215). Duranton (2011: 13) apparently saw no definite specimens from French Guiana, and the species is not mentioned in the checklists for French Guiana by Ponchel (2011) and Dupuis (2016b). There are no recent records from the Guianas and the literature suggests this species has a more southern distribution. We regard this species as not occurring in the research area.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 175, DOI: 10.5281/zenodo.3678492
Mathematical models of mechanisms underlying long-term type 2 diabetes progression
Creators: name: Graham, Erica J.
Publisher: name: University of Utah
Year: 2012
Subjects: Beta-cell dysfunction
Insulin resistance
Mathematical biology
Mathematical modeling
Mathematical physiology
Type 2 diabetes

description: We develop a series of mathematical models incorporating proposed mechanisms underlying the development of two essential features of long-term type 2 diabetes progression: insulin resistance and ¯-cell dysfunction. Reduced insulin-stimulated plasma glucose uptake (insulin resistance) and inadequate insulin production by ¯ cells (¯-cell dysfunction) lead to a number of metabolic irregularities. We study the interaction of oxidative stress and mitochondrial dysfunction in the development of skeletal muscle insulin resistance, focusing on mitochondrial superoxide production and the functional and physical heterogeneities among mitochondria. We explore primary determinants in ¯-cell failure, from the perspective of endoplasmic reticulum stress and the unfolded protein response. We conclude with a basis for age-related insulin resistance, an explanation of the fundamental role of nutrient excess in the decline of metabolic health, and an identification of the interplay of cellular and molecular mechanisms important in metabolic dysregulation.
Safe production model for small mines
Creators: name: Suryanto, Sony Tjahyo
Publisher: name: University of Utah
Year: 2012
Subjects: Mine safety
Mine management

description: A review of MSHA records for 2002-2006 shows that the average fatality injury  rate for small mines (employing fewer than 20 workers) was three times greater than the  fatality injury rate for all US mines. High fatality rates interrupt the continuity of the  mining process and also affect a company's financial situation negatively. In an attempt  to obtain in-depth information, 17 small mines located in the western US have been  inspected as part of this study. A quick review of this information showed that these  mines are facing three common problems: 1) dependency on independent or outside  contractors, 2) multitask assignments, and 3) inadequate training evaluation (identified  through observations). Poor management commitment to safety and limited resources are  the root causes for the recurrence of these problems. To overcome these problems, small  mine operators urgently require a safe production model or a procedure to achieve their  goals and improve their safety records.  In this thesis, eight key safe production elements have been identified:  1) management commitment and leadership, 2) hiring process, 3) training and evaluation,  4) hazard identification and risk assessment, 5) accident investigation, 6) safety policies  and procedures, 7) safety accountability, and 8) communication and participation. These  elements have been used as tools to build a Safe Production Model for Small Mines. This  model involves the following three major activities: developing human resources, adding
Development of a fluorogenic ADAMTS-7 substrate
Creators: name: Santamaria, Salvatore
name: Buemi, Frederic
name: Nuti, Elisa
name: Cuffaro, Doretta
name: De Vita, Elena
name: Tuccinardi, Tiziano
name: Rossello, Armando
name: Howell, Steven
name: Mehmood, Shahid
name: Snijders, Ambrosius P.
name: de Groot, Rens
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology

description: The extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far. Screening of inhibitors has been hindered by the lack of a suitable peptide substrate and, consequently, a convenient activity assay. Here we describe the first fluorescence resonance energy transfer (FRET) substrate for ADAMTS-7, ATS7FP7. ATS7FP7 was used to measure inhibition constants for the endogenous ADAMTS-7 inhibitor, TIMP-4, as well as two hydroxamate-based zinc chelating inhibitors. These inhibition constants match well with IC50 values obtained with our SDS-PAGE assay that uses the N-terminal fragment of latent TGF-β–binding protein 4 (LTBP4S-A) as a substrate. Our novel fluorogenic substrate ATS7FP7 is suitable for high throughput screening of ADAMTS-7 inhibitors, thus accelerating translational studies aiming at inhibition of ADAMTS-7 as a novel treatment for cardiovascular diseases such as atherosclerosis and CAD.
Chemical and biological studies of secondary metabolites from Lissoclinum patella
Creators: name: Richardson, Adam David
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Sea Squits
subject: Physiology
subject: FOS: Biological sciences
subject: Marine Metabolites

description: The investigation of the molecular biology of cancer and the discovery of novel anticancer agents are mutually beneficial research topics. Understanding the biology of cancer leads to improved drug design and target selection while describing new drugs and mechanisms of action may result in an increased knowledge of the workings of cancer. Marine organisms continue to be a source of bioactive secondary metabolites. Investigations of Lissoclinum patella
Cyclocephala munda Kirsch 1871
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala munda

description: Cyclocephala munda Kirsch, 1871
Cyclocephala munda Kirsch 1871: 355 (371) (Peru - LECTOTYPE)
Distribution. Suriname: Endrödi 1985a: 89, 122; Ratcliffe 1992: 183; Moore et al. 2018b: 218. French Guiana: Endrödi 1966a: 263; Duranton 2011: 14; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 218. Brazil (NA): Ratcliffe 1992: 183 (NA); Moore et al. 2018b: 218. Other: Kirsch 1871: 355 (371) (Colombia); Arrow 1937b: 13 (Colombia); Blackwelder 1944: 252 (Colombia); Endrödi 1966a: 263 (Colombia, Peru - designation LECTOTYPE Cyclocephala munda), 1985a: 89, 122 (Colombia, Peru); Ratcliffe 1992: 183 (Colombia, Peru); Moore et al. 2018b: 218 (Colombia, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 175, DOI: 10.5281/zenodo.3678492
Brief an [Johann Andreas Schmidt]
Creators: name: Leibniz, Gottfried Wilhelm
Publisher: name: [s.n.]
Year: 1699

description: von G[ottfried] W[ilhelm] L[eibniz]
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Druck: Leibniz, Gottfried Wilhelm 1646-1716. - G. G. Leibnitii epistolae ad Ioannem Andream Schmidium theologum Helmstadiensem ... / edidit Georgius Veesenmeyer. - Norimbergae, 1788, 74-75
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Interactive digital photography at scale
Creators: name: Summa, Brian Mark
Publisher: name: University of Utah
Year: 2013

description: Interactive editing and manipulation of digital media is a fundamental component in digital content creation. One media in particular, digital imagery, has seen a recent increase in popularity of its large or even massive image formats. Unfortunately, current systems and techniques are rarely concerned with scalability or usability with these large images. Moreover, processing massive (or even large) imagery is assumed to be an off-line, automatic process, although many problems associated with these datasets require human intervention for high quality results. This dissertation details how to design interactive image techniques that scale. In particular, massive imagery is typically constructed as a seamless mosaic of many smaller images. The focus of this work is the creation of new technologies to enable user interaction in the formation of these large mosaics. While an interactive system for all stages of the mosaic creation pipeline is a long-term research goal, this dissertation concentrates on the last phase of the mosaic creation pipeline - the composition of registered images into a seamless composite. The work detailed in this dissertation provides the technologies to fully realize interactive editing in mosaic composition on image collections ranging from the very small to massive in scale.
Brief an J[ohan]n B[ernoulli]
Creators: name: Le Bauld-de-Nans, Claude Étienne
Publisher: name: [s.n.]
Year: 1783

description: von Le Bauld-de Nans
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
A program logic and its application in fully verified software fault isolation
Creators: name: Zhao, Lu
Publisher: name: University of Utah
Year: 2012
Subjects: Software fault isolation
Trusted computing base
TCB
Hoare logic

description: Trusted computing base (TCB) of a computer system comprises components that must be trusted in order to support its security policy. Research communities have identified the well-known minimal TCB principle, namely, the TCB of a system should be as small as possible, so that it can be thoroughly examined and verified. This dissertation is an experiment showing how small the TCB for an isolation service is based on software fault isolation (SFI) for small multitasking embedded systems. The TCB achieved by this dissertation includes just the formal definitions of isolation properties, instruction semantics, program logic, and a proof assistant, besides hardware. There is not a compiler, an assembler, a verifier, a rewriter, or an operating system in the TCB. To the best of my knowledge, this is the smallest TCB that has ever been shown for guaranteeing nontrivial properties of real binary programs on real hardware. This is accomplished by combining SFI techniques and high-confidence formal verification. An SFI implementation inserts dynamic checks before dangerous operations, and these checks provide necessary invariants needed by the formal verification to prove theorems about the isolation properties of ARM binary programs. The high-confidence assurance of the formal verification comes from two facts. First, the verification is based on an existing realistic semantics of the ARM ISA that is independently developed by Cambridge researchers. Second, the verification is conducted in a higher-order proof assistant-the HOL theorem prover, which mechanically checks every verification step by rigorous logic. In addition, the entire verification process, including both specification generation and verification, is automatic. To support proof automation, a novel program logic has been designed, and an automatic reasoning framework for verifying shallow safety properties has been developed. The program logic integrates Hoare-style reasoning and Floyd's inductive assertion reasoning together in a small set of definitions, which overcomes shortcomings of Hoare logic and facilitates proof automation. All inference rules of the logic are proven based on the instruction semantics and the logic definitions. The framework leverages abstract interpretation to automatically find function specifications required by the program logic. The results of the abstract interpretation are used to construct the function specifications automatically, and the specifications are proven without human interaction by utilizing intermediate theorems generated during the abstract interpretation. All these work in concert to create the very small TCB.
Microfluidic techniques for DNA melting analysis and digital polymerase chain reaction
Creators: name: Sundberg, Scott Owen
Publisher: name: University of Utah
Year: 2012
Subjects: Circulating tumor cells
Digital PCR
DNA melting analysis
Microfluidics
PCR

description: Microfluidic methods were applied to nucleic acid mutation identification and quantification. DNA melting analysis interrogation volumes were reduced 4 orders of  magnitude (down to 1 nL volumes) from commercial instrumentation, allowing less reagent consumption while yielding adequate signal for genotyping and scanning of  polymerase chain reaction (PCR) products. A microfluidic instrument was developed for digital PCR applications, using a spinning plastic disk patterned by xurography. Theplatform offers faster thermocycling times (30 cycles in ~12 min), simplified fluid partitioning, and a less expensive disposable when compared to currently available digital PCR platforms. PCR within the disk was validated by quantifying plasmid DNA sample using "on/off" fluorescence interrogation across 1000 wells (30 nL/well) at varying template concentration. A 94% PCR efficiency and product amplification specificity were determined by aggregate real-time PCR and melting analysis. The technique of quasi-digital PCR was also applied within this platform, wherein a single mutation copy was preferentially amplified from a large background of wild-type DNA, to detect and quantify low levels of rare mutations. This method demonstrated a sensitivity of 0.01% (detecting a mutant to wild-type DNA ratio of 43:450000), by mixing known concentrations of an oncogene mutation with thousands of wild-type template copies. Statistic analysis tools were constructed in order to interpret digital PCR data, with results comparing well to DNA absorption measurements.
Cyclocephala ocellata in Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala ocellata

description: Cyclocephala ocellata Burmeister, 1847
Cyclocephala ocellata Burmeister 1847: 40 (Mexico - LECTOTYPE)
Distribution. Suriname: NZCS - NEW COUNTRY RECORD (Suriname. 7-VIII-1952. Geijskes. Savanne.). French Guiana: Dechambre 1979c: 164; Lachaume 1992: 14; Ratcliffe 1992: 184; Duranton 2011: 14; Ponchel 2011: 60; Brûlé et al. 2014: 181; Dupuis 2016b: 109; Moore et al. 2018b: 223. Brazil (NA): Blackwelder 1944: 252; Ratcliffe 1992: 184 (NA); Andreazze and Fonseca 1998: 61 (NA); Moore et al. 2018b: 223. “Amazon Basin”: Arrow 1937b: 14. Other: Burmeister 1847: 40 (Mexico); Endrödi 1966a: 272 (Ecuador, Peru), 1985a: 73, 126 (Ecuador, Peru); Dechambre 1979c: 164 (Ecuador, Peru),
1991: 124 (Mexico - designation LECTOTYPE Cyclocephala ocellata); Lachaume 1992: 14 (Ecuador, Peru); Ratcliffe 1992: 184 (Ecuador, Peru); Moore et al. 2018b: 223 (Colombia, Ecuador, Peru).
Note. The recording of Mexico as the type locality of Cyclocephala ocellata in Burmeister (1847: 40) is an error according to Endrödi (1966a: 272), and the true origin of the lectotype designated in Dechambre (1991: 124) remains unclear. Despite the erroneous type locality of Mexico, the species is not mentioned in the treatment of the Dynastinae of Mexico, Guatemala and Belize by Ratcliffe et al. (2013). Based on the available literature, the species appears to be restricted to parts of northern South America.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 175-176, DOI: 10.5281/zenodo.3678492
Brief an [Johann Bernoulli]
Creators: name: Lauer-Münchhofen, Adolf Julius von
Publisher: name: [s.n.]
Year: 1781

description: von [Julius Adolph] Laur [von Münchhofen]
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
DATA-DRIVEN APPROACHES FOR UNCERTAINTY QUANTIFICATION WITH PHYSICS MODELS
Creators: name: Li, Huiru
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 401799
subject: Mechanical engineering not elsewhere classified
classificationCode: 401706
subject: Numerical modelling and mechanical characterisation
classificationCode: 401704
subject: Mechanical engineering asset management

description: This research aims to address these critical challenges in uncertainty quantification. The objective is to employ data-driven approaches for UQ with physics models.
Multilayer graphene and carbon nanoribbon-based photodetectors: fabrication and photoresponse measurement
Creators: name: Sun, Rujie
Publisher: name: University of Utah
Year: 2014
Subjects: Epitaxial graphene
Graphene
Multilayer graphene
Nanopatterning
Photodetector
Photoresponse

description: The focus of this dissertation is to study the multilayer graphene and carbon nanoribbon-based photodetectors through the fabrication of features like films, islands, mesas, as well as nanoribbons. The corresponding photoresponse was next explored with the realization of photodetecting devices. Graphene-based photodetectors have been fabricated and studied for a long time, and the mechanism of the photoinduced carriers in such photodetectors is still not clear. In addition, the photoresponsivity of graphene photodetectors is still improvable. Based on the research of the photoresponse experiment of multilayer graphene and carbon nanoribbon-based photodetectors, the mechanism for the photodetecting is further discussed and the photoresponsivity is highly improved by different methodologies. Specifically, this dissertation includes the following five chapters of topics: (1) introductions; (2) graphite / multilayer graphene photodetectors; (3) tunable photoresponse of epitaxial graphene on SiC; (4) photoresponse in carbon nanoribbon-based devices; and (5) conclusions. Overall, my dissertation achieves the goal of fundamental discussion of photodetecting in multilayer graphene and carbon nanoribbon-based devices and realizes the improved and tunable photoresponse in the meantime. I hope that this dissertation will help move forward graphene/carbon materialbased research, which is not only limited to the device fabrication and nanopatterning technology but also to achieve a better output of photodetectors.
Brief an die [Redaktion der] Nouvelles de la République des Lettres"
Creators: name: Leibniz, Gottfried Wilhelm
Publisher: name: [s.n.]
Year: 1706

description: von [Gottfried Wilhelm] von L[eibniz]
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Druck: Leibniz, Gottfried Wilhelm 1646-1716. - Mathematische Schriften / Gottfried Wilhelm Leibniz ; hrsg. von C. I. Gerhardt. - Berlin : Asher, 5, 1858, 389-392
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Beyond together: education for the community
Creators: name: Cooke, Adam
name: Sharma, Maya
Publisher: name: University of Manchester
Year: 2022
Subjects: Other education not elsewhere classified

description: A showcase of collaborations between TLS and RACE Centre colleagues in blending expertise of archives, teaching and learning and community partnerships to create a future-proofed education offer. A critical discussion of the goals and structure of our widening access provision for students from underrepresented and global majority communities. With a strong anti-racist pedagogy and commitment to our civic engagement and social responsibility goals. Come and shape the future ambitions of our widening access and success provision for students, educators and community partners.
Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation
Creators: name: Ahmed, Marwa F.
name: Santali, Eman Y.
name: El-Haggar, Radwan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro against 60 human cancer cells lines. Preliminary screening of the examined compounds indicated promising anticancer activity against number of cell lines. The enzyme inhibitory activity against VEGFR-2 was evaluated and IC50 of the tested compounds ranged from 0.57 µM to 1.48 µM. The most potent derivatives Vd and Ve were subjected to further investigations. A cell cycle analysis showed that both compounds mainly arrest HCT-116 cell cycle in the G2/M phase. Annexin V-FITC apoptosis assay showed that Vd and Ve induced an approximately 18.7-fold and 21.2-fold total increase in apoptosis compared to the control. Additionally, molecular docking study was performed against VEGFR (PDB ID: 4ASD) using MOE 2015.10 software and Sorafenib as a reference ligand.
Brief an [Johann Bernoulli]
Creators: name: Laurenz, Johann Daniel
Publisher: name: [s.n.]
Year: 1780

description: von [Johann Daniel] Laurentz
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Druck: Miscellaneen artistischen Inhalts / hrsg. von Johann Georg Meusel. - Erfurt : Keyser, 8, 1781, 122-123
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studies
Creators: name: Tahir, Tehreem
name: Shahzad, Mirza Imran
name: Tabassum, Rukhsana
name: Rafiq, Muhammad
name: Ashfaq, Muhammad
name: Hassan, Mubashir
name: Kotwica-Mojzych, Katarzyna
name: Mojzych, Mariusz
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: In the present study, a series of azo derivatives (TR-1 to TR-9) have been synthesised via the diazo-coupling approach between substituted aromatic amines with phenol or naphthol derivatives. The compounds were evaluated for their therapeutic applications against alpha-glucosidase (anti-diabetic) and pathogenic bacterial strains E. coli (gram-negative), S. aureus (gram-positive), S. aureus (gram-positive) drug-resistant strain, P. aeruginosa (gram-negative), P. aeruginosa (gram-negative) drug-resistant strain and P. vulgaris (gram-negative). The IC50 (µg/mL) of TR-1 was found to be most effective (15.70 ± 1.3 µg/mL) compared to the reference drug acarbose (21.59 ± 1.5 µg/mL), hence, it was further selected for the kinetic studies in order to illustrate the mechanism of inhibition. The enzyme inhibitory kinetics and mode of binding for the most active inhibitor (TR-1) was performed which showed that the compound is a non-competitive inhibitor and effectively inhibits the target enzyme by binding to its binuclear active site reversibly.
Evaluation of the asphalt mixture performance tester (AMPT)
Creators: name: Roberts, Levi A.
Publisher: name: University of Utah
Year: 2012
Subjects: AMPT
Asphalt
Dynamic
Modulus
SPT
Utah

description: Between 2007 and 2008, the Utah Department of Transportation (UDOT) has been collecting field material and testing it using the Asphalt Mixture Performance Tester (AMPT). Thirty-four field mixtures were evaluated as part of this study. The mixtures were produced following UDOT standard volumetric specifications and two binder grades, PG 64-34 and PG 70-28, from three suppliers. Based on the evaluation of the results obtained from these tests, it was found that the AMPT produced data with a coefficient of variation below 15%, indicating good repeatability. Mixtures prepared with different binder grades were easily separated. The dynamic modulus master curves of mixtures prepared using the same binder grade were essentially the same regardless of the aggregate source (same type of mixture was used). Given these results, it was shown that it is possible to obtain asphalt mixture level 1 MEPDG input parameters based on historic data, knowledge of the binder grade used and testing at only 1 temperature. The single temperature test can be used for quality control and to verify that the mixture is of the same kind as the historical data available. This approach can significantly reduce the time and effort required to obtain AMPT data without any loss in performance prediction capacity, thus making adoption of this device more appealing to state DOT's.
Brief an [Johann Bernoulli]
Creators: name: Lauer-Münchhofen, Adolf Julius von
Publisher: name: [s.n.]
Year: 1780

description: von [Julius Adolph] Laur [von Münchhofen]
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Cyclocephala octopunctata Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala octopunctata

description: § Cyclocephala octopunctata Burmeister, 1847
Cyclocephala 8-punctata Burmeister 1847: 65 (Brazil - LECTOTYPE)
Distribution. French Guiana: Burmeister 1847: 65; Endrödi 1966a: 274, 1985a: 79, 136; Dechambre 1991: 124; Duranton 2011: 14 (?); Moore et al. 2018b: 224. “Guianas”: Arrow 1937b: 14; Blackwelder 1944: 252. Brazil: Endrödi 1966a: 274 (designation NEOTYPE Cyclocephala octopunctata), 1985a: 79, 136; Dechambre 1991: 124 (designation LECTOTYPE Cyclocephala octopunctata); Moore et al. 2018b: 224. Other: Endrödi 1966a: 274, 1985a: 79, 136; Moore et al. 2018b: 224.
Note 1. The neotype of Cyclocephala octopunctata designated in Endrödi (1966a: 274) was rendered invalid when type material from Burmeister was recovered and a lectotype was designated in Dechambre (1991: 124). It is unclear to us which reasoning is followed by Dechambre (1991) in designating the Brazilian lectotype, as Burmeister (1847: 65) only mentions French Guiana in the original description. The list of collections through which the lectotype has passed according to Dechambre (1991) does not include the one of Dupont, which contained the material that Burmeister (1847) used for his description. We consider the validity of the lectotype questionable. Regardless of the validity of the lectotype designated by Dechambre (1991), the neotype designated by Endrödi (1966a) remains invalid since it violates several demands of Article 75 of the ICZN (1964: 81), as mentioned by Moore et al. (2018b: 107).
Note 2. Burmeister (1847: 65) describes Cyclocephala octopunctata from French Guiana, and this record is copied in Arrow (1937b: 14), Blackwelder (1944: 252), Endrödi (1966a: 274, 1985a: 79, 136), Dechambre (1991: 124) and Moore et al. (2018b: 224). Duranton (2011: 14) apparently saw no definite specimens from French Guiana, and the species is not mentioned in the checklists for French Guiana by Ponchel (2011) and Dupuis (2016b). We are unaware of any recent reports from the Guianas. Given that this species is otherwise only known from southern Brazil, Bolivia and Peru, we assume that Burmeister’s type specimen was mislabeled and regard this species as not occurring in the research area.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 176, DOI: 10.5281/zenodo.3678492
Hypothetical genetic disease risk moderates the effect of message framing on sunscreen attitudes and intentions
Creators: name: Taber, Jennifer Michelle
Publisher: name: University of Utah
Year: 2012
Subjects: Genetic disease risk
Health behavior

description: Health communications vary in persuasiveness according to whether the costs or benefits of engaging in a health behavior are emphasized. Generally, individuals at population risk engage in higher levels of prevention behaviors after being presented with a gain frame;  however, few studies have examined whether these findings apply to individuals given extremely elevated disease risk estimates, as would be true of high-risk cancer-prone family members. In the present study, 146 undergraduate participants watched a detailed video of a simulated genetic counseling session and were asked to imagine that they were undergoing genetic testing for melanoma.
Cyclocephala ohausiana Hohne 1923
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala ohausiana

description: Cyclocephala ohausiana Höhne, 1923
Cyclocephala ohausiana Höhne 1923b: 362 (Brazil - LECTOTYPE)
Distribution. French Guiana: Brûlé et al. 2011b: 120; Duranton 2011: 14; Ponchel 2011: 60; Dupuis 2016b: 109. Brazil: Höhne 1923b: 362; Arrow 1937b: 14; Blackwelder 1944: 252; Endrödi 1966a: 275 (designation LECTOTYPE Cyclocephala ohausiana), 1985a: 64, 129; Moore et al. 2018b: 224.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 176, DOI: 10.5281/zenodo.3678492
Beyond together: education for the community
Creators: name: Cooke, Adam
Publisher: name: University of Manchester
Year: 2022
Subjects: Other education not elsewhere classified

description: A showcase of collaborations between TLS and RACE Centre colleagues in blending expertise of archives, teaching and learning and community partnerships to create a future-proofed education offer. A critical discussion of the goals and structure of our widening access provision for students from underrepresented and global majority communities. With a strong anti-racist pedagogy and commitment to our civic engagement and social responsibility goals. Come and shape the future ambitions of our widening access and success provision for students, educators and community partners.
Statistically testable parameter drug interaction modeling
Creators: name: Fidler, Matthew Larry
Publisher: name: University of Utah
Year: 2012
Subjects: Mathematical Models
Drug Interactions

description: The purpose of this research is to (1) produce a model allowing statistical tests of interaction behavior, (2) assess the model's difference from classical interactions, (3) compare to previous models, (4) find an experimental design to determine the drug ratio of most interaction, and (5) apply the model to a dataset that samples a scope of data where 50% of one drug is not achieved. The proposed model or STP model gives fits similar in its ability to describe data observed to a polynomial model described by Minto. The model introduces statistically testable summary parameters (STP) for interactions, best ratio for maximum interaction, change in Hill slope, and change in maximum effect. The differences in classification between STP interactions and traditional interactions are small. The STP model can approximate Finney, Single Hill Constant and Minto models. The drug ratio giving the most interaction can be estimated by administering set ratios of drugs to at least 10 patients. Without sampling data including the 50% effect of one drug, interaction statements are difficult to make with the STP model alone. Still, the STP model adequately predicts the interaction surfaces.
Application of Knowledge Discovery in Databases Methodologies for Predictive Models for Pregnancy Adverse Events
Creators: name: Taft, Laritza M.
Publisher: name: University of Utah
Year: 2014

description: In its report To Err is Human, The Institute of Medicine recommended the implementation of internal and external voluntary and mandatory automatic reporting systems to increase detection of adverse events. Knowledge Discovery in Databases (KDD) allows the detection of patterns and trends that would be hidden or less detectable if analyzed by conventional methods. The objective of this study was to examine novel KDD techniques used by other disciplines to create predictive models using healthcare data and validate the results through clinical domain expertise and performance measures. Patient records for the present study were extracted from the enterprise data warehouse (EDW) from Intermountain Healthcare. Patients with reported adverse events were identified from ICD9 codes. A clinical classification of the ICD9 codes was developed, and the clinical categories were analyzed for risk factors for adverse events including adverse drug events. Pharmacy data were categorized and used for detection of drugs administered in temporal sequence with antidote drugs. Data sampling and data boosting algorithms were used as signal amplification techniques. Decision trees, Naïve Bayes, Canonical Correlation Analysis, and Sequence Analysis were used as machine learning algorithms. iv Performance measures of the classification algorithms demonstrated statistically significant improvement after the transformation of the dataset through KDD techniques, data boosting and sampling. Domain expertise was applied to validate clinical significance of the results. KDD methodologies were applied successfully to a complex clinical dataset. The use of these methodologies was empirically proven effective in healthcare data through statistically significant measures and clinical validation. Although more research is required, we demonstrated the usefulness of KDD methodologies in knowledge extraction from complex clinical data.
Brief an [Johann] Bernoulli
Creators: name: Le Bauld-de-Nans, Claude Étienne
Publisher: name: [s.n.]
Year: 1786

description: von Le Bauld-de Nans
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
Creators: name: Khattab, Reham R.
name: Alshamari, Asma K.
name: Hassan, Allam A.
name: Elganzory, Hussein H.
name: El-Sayed, Wael A.
name: Awad, Hanem M.
name: Nossier, Eman S.
name: Hassan, Nasser A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2, 5, 7, and 13–18 was studied against HCT-116 and MCF-7 cell lines by the MTT assay. The triazole glycosides 16 and 18 provided significant cytotoxic activities against HCT-116 cell lines comparable to that of doxorubicin and other studied compounds. The cytotoxic behaviour against MCF-7 exhibited that all the investigated compounds were more potent than doxorubicin. Moreover, all screened targets were evaluated against mutant EGFR kinase type L858R and the results revealed that the acetylated 1,2,3-triazole glycosides 13–18 exhibited excellent EGFR inhibitory activity in comparison with gefitinib. Furthermore, molecular modelling studies were performed to investigate the binding affinity of the most active compounds to EGFR enzyme.
Effects of cellular activation on lymphocyte recirculation
Creators: name: Huang, Kun
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Pertussis Toxin

description: Circulating lymphocytes emigrate from the blood into most secondary lymphoid organs by selective adherence to specialized vascular structures, termed high endothelial venules (HEV), and subsequent active translocation. Besides lymphocyte-HEV recognition and adhesion, which depends on productive interactions between the organ specific lymphocyte homing receptors and the vascular addressins, lymphocytes must possess the capacity to physically penetrate and traverse the endothelium. It has been known that resting and activated lymphocytes exhibit distinct homing patterns, yet the mechanisms responsible for controlling their migration are not fully elucidated.  Exposure of murine lymphocytes to pertussis toxin or phorbol esters before they are transfused into normal syngeneic hosts markedly depress their ability to localize into lymph nodes and Peyer's patches. Mechanisms responsible for the altered homing behavior of these lymphocytes were investigated here. Pertussis toxin-treated lymphocytes were found to express normal levels of peripheral lymph node-specific homing receptor (MEL-14 receptor) and be able to attach to peripheral lymph node HEV. In contrast, phorbol ester-induced protein kinase C activation of lymphocytes caused a marked reduction in phenotypic and functional expression of the MEL-14 receptor. The loss of MEL-14 receptor expression was due to a rapid shedding of the receptor from the activated lymphocytes. Although localization of phorbol ester-treated lymphocytes into Peyer's patches is inhibited, normal levels of Peyer's patch HEV-specific homing receptor were expressed by these cells. Therefore, modulation of the surface expression of lymphocyte homing receptors comprises one of the mechanisms that regulate the homing of activated lymphocytes. However homing receptor expression is insufficient to support lymphocyte extravasation.  The finding that PKC activation of lymphocytes changes their homing behavior and their surface expression of MEL-14 receptor provides a new system for studying the recirculation of activated lymphocytes, and a basis for further experimentation to investigate the molecular mechanisms which mediate the release of the MEL-14 receptor by activated lymphocytes. The observation that the MEL-14 receptor and the Peyer's patch HEV-specific homing receptor are differentially regulated by activated lymphocytes also provide useful information for identifying new receptors with other specificities. The physiological relevance of the downregulation of MEL-14 receptor and differential regulation of distinct homing receptors to the immune functions of activated lymphocytes await to be determined.
Beschreibung seiner Bücher-, Münz- und Bildersammlung
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1743

description: von [Carl Benjamin Lengnich]
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Liste von Mineraliensammlungen etc : in Schweden, Dänemark, Deutschland und Österreich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1702

description: von J. G.
description: Öffentliche Bibliothek der Universität Basel
description: Englisch
description: Verzeichnung=Description=Inventaire Februar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases
Creators: name: Mokhtar, Mohamed
name: Alghamdi, Khadijah S.
name: Ahmed, Nesreen S.
name: Bakhotmah, Dina
name: Saleh, Tamer S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesised under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The new compounds 4b, 4j, 4k, and 4e exhibited the most potent cytotoxic activity of IC50 values (0.002 − 0.004 µM) comparing to Staurosporine of IC50; 0.005 μM. The latter derivatives exhibited a promising safety profile against the normal human WI38 cells of IC50 range 0.0149 − 0.048 µM. Furthermore, the most promising cytotoxic compounds 4b, 4j were evaluated as multi-targeting agents against the RTK protein kinases; EGFR, HER-2, PDGFR-β, and VEGFR-2. Compound 4j showed promising inhibitory activity against HER-2 and PDGFR-β of IC50 values 0.17 × 10−3, 0.07 × 10−3 µM in comparison with the reference drug sorafenib of IC50; 0.28 × 10−3, 0.13 × 10−3 µM, respectively. In addition, 4j induced apoptotic effect and cell cycle arrest at G2/M phase preventing the mitotic cycle in MCF-7 cells.
Cyclocephala olivieri Arrow 1911
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala olivieri

description: Cyclocephala olivieri Arrow, 1911
Cyclocephala olivieri Arrow 1911b: 171 (none)
= Melolontha melanocephala Olivier 1789: 42 (Suriname, French Guiana, Brazil)
= Melolontha nigrocephala Schönherr 1817: 190 (French Guiana, Brazil)
Distribution. Suriname: Olivier 1789: 42 (as Melolontha melanocephala); Moore et al. 2018b: 224. French Guiana: Olivier 1789: 42 (as Melolontha melanocephala); Schönherr 1817: 190 (as Melolontha nigrocephala). “Guianas”: Arrow 1937b: 14; Blackwelder 1944: 252. Brazil: Olivier 1789: 42 (as Melolontha melanocephala); Schönherr 1817: 190 (as Melolontha nigrocephala); Endrödi 1966a: 276, 1985a: 110, 146; Moore et al. 2018b: 224. Venezuela (EO): Endrödi 1966a: 276, 1985a: 110, 146; Moore et al. 2018b: 224 (EO). Other: Arrow 1911b: 171 (none), 1937b: 14 (Colombia); Blackwelder 1944: 252 (Colombia); Endrödi 1966a: 276 (Argentina, Bolivia, Colombia, Paraguay, Trinidad and Tobago), 1985a: 110, 146 (Argentina, Bolivia, Colombia, Paraguay, Trinidad and Tobago); Ponchel 2011 (not mentioned);
Dupuis 2016b (not mentioned); Moore et al. 2018b: 224 (Argentina, Bolivia, Colombia, Paraguay, Trinidad and Tobago, Uruguay).
Note. We are unaware of any recent records of Cyclocephala olivieri from the Guianas and consider its occurrence there in need of confirmation.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 176-177, DOI: 10.5281/zenodo.3678492
Preislisten von Medaillen und Büchern
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1743

description: von [Carl Benjamin Lengnich]
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Februar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog