cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Impact of off‐label use regulations on patient care in dermatology – a prospective study of cost‐coverage applications filed by tertiary dermatology clinics throughout Germany
Creators: name: Werner, R.N.
name: Pennitz, A.
name: Eisert, L.
name: Schmidle, P.
name: Zink, A.
name: Abraham, S.
name: Schäkel, K.
name: Wolff, I.
name: Goebeler, M.
name: Plange, J.
name: Sollfrank, L.
name: Zielbauer, S.
name: Koll, P.
name: Amschler, K.
name: Müller, V.
name: Nast, A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: biological products
subject: dermatology
subject: Germany
subject: Janus Kinase Inhibitors
subject: off-label use
subject: patient care
subject: practice patterns, physicians'
subject: prospective studies
subject: rare diseases
classificationCode: 610
subject: Medizin und Gesundheit

description: Background In dermatology, a medical speciality with a relatively high number of rare diseases, physicians often have to resort to off-label treatment options. To avoid claims, physicians in Germany can file a cost-coverage request (off-label application, OL-A). Objectives Our aim was to investigate the extent to which the current regulations affect patient care. Material and methods Prospective cohort study among tertiary dermatology clinics throughout Germany, consecutively including OL-As (05/2019–09/2020) and assessing the follow-up correspondence. We modelled regressions to assess factors associated with cost-coverage decisions and the time needed by health insurers to process the OL-As. Results Thirteen clinics provided data on 121 OL-As, two of which applied for on-label treatments. Of the remaining 119 OL-As, 70 (58.8%) were immediately approved and 44 (37.0%) rejected. Including cases with one or more appeals, 87 of 119 OL-As (73.1%) were finally approved and 26 (21.9%) rejected. There was an association of the final approval rate with (1) the class of medication/treatment, with approval rates being significantly lower for JAK inhibitors than for biologics (OR 0.16, 95%-CI: 0.03–0.82); (2) German state, with approval rates being lower in eastern than in western states (OR 0.30, 95%-CI 0.12–0.76); and (3) cost of the intervention (no linear trend). However, none of these predictors was significant in our multiple logistic regression models. The median health insurer's processing time (first response) was 29 days (IQR 22–38). Our analyses showed no evidence of an association with the predictors we assessed. In cases approved, the median time from the decision to file an OL-A to the actual initiation of the treatment was 65.5 days (IQR 51–92). Conclusions Our study points to substantial delays and inequalities in the provision of timely health care for dermatological patients with rare diseases, often involving treatments for which there is no adequate approved therapy.
On The Gas Temperature of Molecular Cloud Cores
Creators: name: Juvela, M.
name: Ysard, N.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the uncertainties affecting the temperature profiles of dense cores of interstellar clouds. In regions shielded from external ultraviolet radiation, the problem is reduced to the balance between cosmic ray heating, line cooling, and the coupling between gas and dust. We show that variations in the gas phase abundances, the grain size distribution, and the velocity field can each change the predicted core temperatures by one or two degrees. We emphasize the role of non-local radiative transfer effects that often are not taken into account, for example, when modelling the core chemistry. These include the radiative coupling between regions of different temperature and the enhanced line cooling near the cloud surface. The uncertainty of the temperature profiles does not necessarily translate to a significant error in the column density derived from observations. However, depletion processes are very temperature sensitive and a two degree difference can mean that a given molecule no longer traces the physical conditions in the core centre.
description: 13 pages, 10 figures, accepted to ApJ
Dependence of a planet's chaotic zone on particle eccentricity: the shape of debris disc inner edges
Creators: name: Mustill, Alexander J.
name: Wyatt, Mark C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The orbit of a planet is surrounded by a chaotic zone wherein nearby particles' orbits are chaotic and unstable. Wisdom (1980) showed that the chaos is driven by the overlap of mean motion resonances which occurs within a distance (da/a)_chaos = 1.3 mu^2/7 of the planet's orbit. However, the width of mean motion resonances grows with the particles' eccentricity, which will increase the width of the chaotic zone at higher eccentricities. Here we investigate the width of the chaotic zone using the iterated encounter map and N-body integrations. We find that the classical prescription works well for particles on low-eccentricity orbits. However, above a critical eccentricity, dependent upon the mass of the planet, the width of the chaotic zone increases with eccentricity. An extension of Wisdom's analytical arguments then shows that, above the critical eccentricity, the chaotic zone width is given by (da/a)_chaos = 1.8 e^1/5 mu^1/5, which agrees well with the encounter map results. The critical eccentricity is given by e_cr = 0.21 mu^3/7. This extended chaotic zone results in a larger cleared region when a planet sculpts the inner edge of a debris disc comprised of eccentric planetesimals. Hence, the planet mass estimated from the classical chaotic zone may be erroneous. We apply this result to the HR8799 system, showing that the masses of HR8799b inferred from the truncation of the disc may vary by up to 50% depending on the disc particles' eccentricities. With a disc edge at 90AU, the necessary mass of planet b to cause the truncation would be 8-10 Jovian masses if the disc particles have low eccentricities (<0.02), but only 4-8 Jovian masses if the disc particles have higher eccentricities. Our result also has implications for the ability of a planet to feed material into an inner system, a process which may explain metal pollution in White Dwarf atmospheres.
description: 7 pages, 5 figures. Accepted to MNRAS
title: Treatment patterns and outcomes in patients with chronic urticaria during pregnancy: Results of PREG-CU, a UCARE study
Creators: name: Kocatürk, Emek
name: Al‐Ahmad, Mona
name: Krause, Karoline
name: Gimenez‐Arnau, Ana M.
name: Thomsen, Simon Francis
name: Conlon, Niall
name: Marsland, Alexander
name: Savk, Ekin
name: Criado, Roberta F.
name: Danilycheva, Inna
name: Fomina, Daria
name: Godse, Kiran
name: Khoshkhui, Maryam
name: Gelincik, Aslı
name: Degirmentepe, Ece Nur
name: Demir, Semra
name: Ensina, Luis Felipe
name: Kasperska‐Zajac, Alicja
name: Rudenko, Michael
name: Valle, Solange
name: Medina, Iris
name: Bauer, Andrea
name: Zhao, Zuotao
name: Staubach, Petra
name: Bouillet, Laurence
name: Küçük, Özlem Su
name: Baygül, Arzu
name: Maurer, Marcus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: chronic disease
subject: chronic urticaria
subject: female
subject: Histamine H1 Antagonists
subject: infant, newborn
subject: Omalizumab
subject: pregnancy
subject: premature birth
subject: urticaria
classificationCode: 610
subject: Medizin und Gesundheit

description: Background Although chronic urticaria (CU) is a common and primarily affects females, there is little data on how pregnancy interacts with the disease. Objective To analyse the treatment use by CU patients before, during and after pregnancy as well as outcomes of pregnancy. Methods PREG-CU is an international, multicentre study of the Urticaria Centers of Reference and Excellence network. Data were collected via a 47-item-questionnaire completed by CU patients who became pregnant during their disease course. Results Questionnaires from 288 CU patients from 13 countries were analysed. During pregnancy, most patients (60%) used urticaria medication including standard-dose second generation H1-antihistamines (35.1%), first generation H1-antihistamines (7.6%), high-dose second-generation H1-antihistamines (5.6%) and omalizumab (5.6%). The preterm birth rate was 10.2%; rates were similar between patients who did and did not receive treatment during pregnancy (11.6% vs. 8.7%, respectively). Emergency referrals for CU and twin birth were risk factors for preterm birth. The caesarean delivery rate was 51.3%. More than 90% of new-borns were healthy at birth. There was no link between any patient or disease characteristics or treatments and medical problems at birth. Conclusion Most CU patients used treatment during pregnancy especially second-generation antihistamines which seem to be safe during pregnancy regardless of the trimester. The rates of preterm births and medical problems of new-borns in CU patients were similar to population norms and not linked to treatment used during pregnancy. Emergency referrals for CU increased the risk of preterm birth and emphasize the importance of sufficient treatment to keep urticaria under control during pregnancy.
Updatable Queue Protocol Based On TCP For Virtual Reality Environment
Creators: name: Al-Howaide, Ala'a Z.
name: Khaleel, Mohammed I.
name: Salhieh, Ayad M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: The variance in number and types of tasks required to be implemented within Distributed Virtual Environments (DVE) highlights the needs for communication protocols can achieve consistency. In addition, these applications have to handle an increasing number of participants and deal with the difficult problem of scalability. Moreover, the real-time requirements of these applications make the scalability problem more difficult to solve. In this paper, we have implemented Updatable Queue Abstraction protocol (UQA) on TCP (TCP-UQA) and compared it with original TCP, UDP, and Updatable Queue Abstraction based on UDP (UDP-UQA) protocols. Results showed that TCP-UQA was the best in queue management.
description: 11 pages, 13 fugures, 13 reference
Topological T-duality for torus bundles with monodromy
Creators: name: Baraglia, David
Publisher: name: arXiv
Year: 2012
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 53C08, 19L50, 53D18, 53C80

description: We give a simplified definition of topological T-duality that applies to arbitrary torus bundles. The new definition does not involve Chern classes or spectral sequences, only gerbes and morphisms between them. All the familiar topological conditions for T-duals are shown to follow. We determine necessary and sufficient conditions for existence of a T-dual in the case of affine torus bundles. This is general enough to include all principal torus bundles as well as torus bundles with arbitrary monodromy representations. We show that isomorphisms in twisted cohomology, twisted K-theory and of Courant algebroids persist in this general setting. We also give an example where twisted K-theory groups can be computed by iterating T-duality.
description: 49 pages
title: RIOT-ML: toolkit for over-the-air secure updates and performance evaluation of TinyML models
Creators: name: Huang, Zhaolan
name: Zandberg, Koen
name: Schleiser, Kaspar
name: Baccelli, Emmanuel
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: AI
subject: IoT
subject: Machine learning
subject: Low power
subject: Microcontroller
subject: Benchmarks
subject: Software update
subject: MLOps
classificationCode: 004
subject: Datenverarbeitung; Informatik

description: Practitioners in the field of TinyML lack so far a comprehensive, “batteries-included” toolkit to streamline continuous integration, continuous deployment and performance assessments of executing diverse machine learning models on various low-power IoT hardware. Addressing this gap, our paper introduces RIOT-ML, a versatile toolkit crafted to assist IoT designers and researchers in these tasks. To this end, we designed RIOT-ML based on an integration of an array of functionalities from a low-power embedded OS, a universal model transpiler and compiler, a toolkit for TinyML performance measurement, and a low-power over-the-air secure update framework—all of which usable on an open-access IoT testbed available to the community. Our open-source implementation of RIOT-ML and the initial experiments we report on showcase its utility in experimentally evaluating TinyML model performance across fleets of low-power IoT boards under test in the field, featuring a wide spectrum of heterogeneous microcontroller architectures and fleet network connectivity configurations. The existence of an open-source toolkit such as RIOT-ML is essential to expedite research combining artificial intelligence and IoT and to foster the full realization of edge computing’s potential.
title: The Tropical and Zonotopal Geometry of Periodic Timetables
Creators: name: Bortoletto, Enrico
name: Lindner, Niels
name: Masing, Berenike
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Periodic timetabling
subject: Tropical geometry
subject: Polytropes
subject: Zonotopes
subject: Zonotopal tilings
classificationCode: 510
subject: Mathematik

description: The Periodic Event Scheduling Problem (PESP) is the standard mathematical tool for optimizing periodic timetables in public transport. A solution to a PESP instance consists of three parts: a periodic timetable, a periodic tension, and integer offset values. While the space of periodic tensions has received much attention in the past, we explore geometric properties of the other two components. The general aim of this paper is to establish novel connections between periodic timetabling and discrete geometry. Firstly, we study the space of feasible periodic timetables as a disjoint union of polytropes. These are polytopes that are convex both classically and in the sense of tropical geometry. We then study this decomposition and use it to outline a new heuristic for PESP, based on neighbourhood relations of the polytropes. Secondly, we recognize that the space of fractional cycle offsets is in fact a zonotope, and then study its zonotopal tilings. These are related to the hyperrectangle of fractional periodic tensions, as well as the polytropes of the periodic timetable space, and we detail their interplay. To conclude, we also use this new understanding to give tight lower bounds on the minimum width of an integral cycle basis.
Additional file 1 of rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms
Creators: name: Hitomi, Yuki
name: Aiba, Yoshihiro
name: Ueno, Kazuko
name: Nishida, Nao
name: Kawai, Yosuke
name: Kawashima, Minae
name: Tsuiji, Makoto
name: Iwabuchi, Chisato
name: Takada, Sanami
name: Miyake, Noriko
name: Nagasaki, Masao
name: Tokunaga, Katsushi
name: Nakamura, Minoru
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Additional tables and figures.
title: "Trapezoforo, sezione", arte romana, inv. CCXXXXIIa (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Clementi, Jessica
name: Gallleria Borguese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di

Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Evidence of a bisymmetric spiral in the Milky Way
Creators: name: Francis, Charles
name: Anderson, Erik
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context: Because of our viewing point within the Galactic disc, it is extremely difficult to observe the spiral structure of the Milky Way. Aims: To clarify the structure of the Galaxy by re-examination of gas distributions and data from 2MASS; to determine stream memberships among local stars and to show the relationship between streaming motions and spiral structure. Methods: We extend the spiral pattern found from neutral gas towards the Galactic centre using data from 2MASS. We select a population of 23 075 local disc stars for which complete kinematic data is available. We plot eccentricity against the true anomaly for stellar orbits and identify streams as dense regions of the plot. We reconstruct the spiral pattern by replacing each star at a random position of the inward part of its orbit. Results: We find evidence in 2MASS of a bar of length 4.2 \pm 0.1 kpc at angle 30 \pm 10\degree. We extend spiral structure by more than a full turn toward the Galactic centre, and confirm that the Milky Way is a two-armed grand-design bisymmetric spiral with pitch angle 5.56 \pm 0.06\degree. Memberships of kinematic groups are assigned to 98% of local disc stars and it is seen that the large majority of local stars have orbits aligned with this spiral structure.
description: Accepted by MNRAS. 11 pages, 19 figures
title: Imaginative Hope
Creators: name: Huber, Jakob
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: hope
subject: imagination
subject: despair
subject: politics
classificationCode: 102
subject: Verschiedenes

description: While political philosophers often assume that we need to imagine a better future in order to hope for it, philosophers of hope doubt that hope and imagination are constitutively intertwined. In order to solve this puzzle, the article introduces a particular kind of hope in which we imaginatively inhabit a desired future. Combining insights from the philosophy of hope and of imagination, I unpack what imaginative hope is and why it is particularly significant in political contexts. I contend that in cases where we pursue a goal the realization of which requires collective action over a long time-scale (as it is paradigmatically the case in politics), the imagination has the potential to bolster the practical value of hope, i.e., its power to guide and sustain our agency.
Toroidal metrics: gravitational solenoids and static shells
Creators: name: Lynden-Bell, Donald
name: Katz, Joseph
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In electromagnetism a current along a wire tightly wound on a torus makes a solenoid whose magnetic field is confined within the torus. In Einstein's gravity we give a corresponding solution in which a current of matter moves up on the inside of a toroidal shell and down on the outside, rolling around the torus by the short way. The metric is static outside the torus but stationary inside with the gravomagnetic field confined inside the torus, running around it by the long way. This exact solution of Einstein's equations is found by fitting Bonnor's solution for the metric of a light beam, which gives the required toroidal gravomagnetic field inside the torus, to the general Weyl static external metric in toroidal coordinates, which we develop. We deduce the matter tensor on the torus and find when it obeys the energy conditions. We also give the equipotential shells that generate the simple Bach-Weyl metric externally and find which shells obey the energy conditions.
description: To appear in Class. Quantum Grav
title: Medical graphics to improve patient understanding and anxiety in elderly and cognitively impaired patients scheduled for transcatheter aortic valve implantation (TAVI)
Creators: name: Brand, A.
name: Hornig, C.
name: Crayen, Claudia
name: Hamann, A.
name: Martineck, S.
name: Leistner, D. M.
name: Dreger, H.
name: Sündermann, S.
name: Unbehaun, A.
name: Sherif, M.
name: Haghikia, A.
name: Bischoff, S.
name: Lueg, J.
name: Kühnle, Y.
name: Paul, O.
name: Squier, S.
name: Stangl, K.
name: Falk, V.
name: Landmesser, U.
name: Stangl, V.
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Informed consent
subject: TAVI
subject: TAVR
subject: Cognitive dysfunction
subject: Medical graphics
subject: Comic
classificationCode: 610
subject: Medizin und Gesundheit

description: Background Anxiety and limited patient comprehension may pose significant barriers when informing elderly patients about complex procedures such as transcatheter aortic valve implantation (TAVI). Objectives We aimed to evaluate the utility of medical graphics to improve the patient informed consent (IC) before TAVI. Methods In this prospective, randomized dual center study, 301 patients were assigned to a patient brochure containing medical graphics (Comic group, n  = 153) or sham information (Control group, n  = 148) on top of usual IC. Primary outcomes were patient understanding of central IC-related aspects and periprocedural anxiety assessed by the validated Spielberger State Trait Anxiety Inventory (STAI), both analyzed by cognitive status according to the Montreal Cognitive Assessment (MoCA). Results Patient understanding was significantly higher in the Comic group [mean number of correct answers 12.8 (SD 1.2) vs. 11.3 (1.8); mean difference 1.5 (95% CI 1.2–1.8); p  < 0.001]. This effect was more pronounced in the presence of cognitive dysfunction (MoCA < 26) [12.6 (1.2) in the Comic vs. 10.9 (1.6) in the Control group; mean difference 1.8 (1.4–2.2), p  < 0.001]. Mean STAI score declined by 5.7 (95% CI 5.1–6.3; p  < 0.001) in the Comic and 0.8 points (0.2–1.4; p  = 0.015) in the Control group. Finally, mean STAI score decreased in the Comic group by 4.7 (3.8–5.6) in cognitively impaired patients and by 6.6 (95% CI 5.8 to 7.5) in patients with normal cognitive function ( p  < 0.001 each). Conclusions Our results prove beneficial effects for using medical graphics to inform elderly patients about TAVI by improving patient understanding and reducing periprocedural anxiety (DRKS00021661; 23/Oct/2020).
Recent collisional jet from a primitive asteroid
Creators: name: Novakovic, Bojan
name: Dell'Oro, Aldo
name: Cellino, Alberto
name: Knezevic, Zoran
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Here we show an example of a young asteroid cluster located in a dynamically stable region, which was produced by partial disruption of a primitive body about 30 km in size. We estimate its age to be only 1.9 +/- 0.3 Myr, thus its post-impact evolution should have been very limited. The large difference in size between the largest object and the other cluster members means that this was a cratering event. The parent body had a large orbital inclination, and was subject to collisions with typical impact speeds higher by a factor of 2 than in the most common situations encountered in the main belt. For the first time we have at disposal the observable outcome of a very recent event to study high-speed collisions involving primitive asteroids, providing very useful constraints to numerical simulations of these events and to laboratory experiments.
description: Accepted for publication by MNRAS
title: SLAMF7 (CD319) on activated CD8+ T cells transduces environmental cues to initiate cytotoxic effector cell responses
Creators: name: Lingel, Holger
name: Fischer, Laura
name: Remstedt, Sven
name: Kuropka, Benno
name: Philipsen, Lars
name: Han, Irina
name: Sander, Jan-Erik
name: Freund, Christian
name: Arra, Aditya
name: Brunner-Weinzierl, Monika C.
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Acute inflammation
subject: T cells
subject: cytotoxic effector cell
classificationCode: 540
subject: Chemie und zugeordnete Wissenschaften

description: CD8+ T-cell responses are meticulously orchestrated processes regulated by intercellular receptor:ligand interactions. These interactions critically control the dynamics of CD8+ T-cell populations that is crucial to overcome threats such as viral infections or cancer. Yet, the mechanisms governing these dynamics remain incompletely elucidated. Here, we identified a hitherto unknown T-cell referred function of the self-ligating surface receptor SLAMF7 (CD319) on CD8+ T cells during initiation of cytotoxic T-cell responses. According to its cytotoxicity related expression on T effector cells, we found that CD8+ T cells could utilize SLAMF7 to transduce environmental cues into cellular interactions and information exchange. Indeed, SLAMF7 facilitated a dose-dependent formation of stable homotypic contacts that ultimately resulted in stable cell-contacts, quorum populations and commitment to expansion and differentiation. Using pull-down assays and network analyses, we identified novel SLAMF7-binding intracellular signaling molecules including the CRK, CRKL, and Nck adaptors, which are involved in T-cell contact formation and may mediate SLAMF7 functions in sensing and adhesion. Hence, providing SLAMF7 signals during antigen recognition of CD8+ T cells enhanced their overall magnitude, particularly in responses towards low-affinity antigens, resulting in a significant boost in their proliferation and cytotoxic capacity. Overall, we have identified and characterized a potent initiator of the cytotoxic T lymphocyte response program and revealed advanced mechanisms to improve CD8+ T-cell response decisions against weak viral or tumor-associated antigens, thereby strengthening our defense against such adversaries.
Pump-probe coupling of matter wave packets to remote lattice states
Creators: name: Sherson, Jacob F.
name: Park, Sung Jong
name: Pedersen, Poul
name: Winter, Nils
name: Gajdacz, Miroslav
name: Mai, Sune
name: Arlt, Jan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The coherent manipulation of wave packets is an important tool in many areas of physics. We demonstrate the experimental realization of quasi-free wave packets of ultra-cold atoms bound by an external harmonic trap. The wave packets are produced by modulating the intensity of an optical lattice containing a Bose-Einstein condensate. The evolution of these wave packets is monitored in-situ and their reflection on a band gap is observed. In direct analogy with pump-probe spectroscopy, a probe pulse allows for the resonant de-excitation of the wave packet into localized lattice states at a long, controllable distance of more than 100 lattice sites from the main component. This coherent control mechanism for ultra-cold atoms thus enables controlled quantum state preparation, opening exciting perspectives for quantum metrology and simulation.
description: 5 pages, 5 figures
Additional file 1 of A scoping review of perceptions from healthcare professionals on antipsychotic prescribing practices in acute care settings
Creators: name: Jaworska, Natalia
name: Moss, Stephana J.
name: Krewulak, Karla D.
name: Stelfox, Zara
name: Niven, Daniel J.
name: Ismail, Zahinoor
name: Burry, Lisa D.
name: Fiest, Kirsten M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
title: Assessing the Speed–Accuracy Tradeoff in Psychological Testing Using Experimental Manipulations
Creators: name: Alfers, Tobias
name: Gittler, Georg
name: Ulitzsch, Esther
name: Pohl, Steffi
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: speed-accuracy tradeoff
subject: experiment
subject: psychological testing
subject: spatial ability
subject: high-stakes
subject: latent change
classificationCode: 150
subject: Psychologie

description: The speed–accuracy tradeoff (SAT), where increased response speed often leads to decreased accuracy, is well established in experimental psychology. However, its implications for psychological assessments, especially in high-stakes settings, remain less understood. This study presents an experimental approach to investigate the SAT within a high-stakes spatial ability assessment. By manipulating instructions in a within-subjects design to induce speed variations in a large sample (N = 1,305) of applicants for an air traffic controller training program, we demonstrate the feasibility of manipulating working speed. Our findings confirm the presence of the SAT for most participants, suggesting that traditional ability scores may not fully reflect performance in high-stakes assessments. Importantly, we observed individual differences in the SAT, challenging the assumption of uniform SAT functions across test takers. These results highlight the complexity of interpreting high-stakes assessment outcomes and the influence of test conditions on performance dynamics. This study offers a valuable addition to the methodological toolkit for assessing the intraindividual relationship between speed and accuracy in psychological testing (including SAT research), providing a controlled approach while acknowledging the need to address potential confounders. Future research may apply this method across various cognitive domains, populations, and testing contexts to deepen our understanding of the SAT’s broader implications for psychological measurement.
Topics in uniform continuity
Creators: name: Dikranjan, Dikran
name: Repovš, Dušan
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 54E11, 54E40, 54C20, 54E35

description: This paper collects results and open problems concerning several classes of functions that generalize uniform continuity in various ways, including those metric spaces (generalizing Atsuji spaces) where all continuous functions have the property of being close to uniformly continuous.
Symplectic large-N theory of topological heavy-fermion semiconductors
Creators: name: Dzero, Maxim
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: I present a theory of topological heavy-fermion semiconductors based on the large-N symplectic representation for the electron spin. The theory is exact in the limit when the number of spin flavors N=2k is infinite. I find that both weak and strong topological insulating phases exist for k<3. Furthermore, for k>2 the weak topological insulating state fully suppressed while only strong topological and trivial insulator states survive. In addition, using the mean-field theory results, I consider the tunneling into topologically trivial and non-trivial phases of a generic heavy-fermion insulators by calculating the differential tunneling conductance. The implications of the presented results for the existing heavy-fermion semiconductors are discussed.
description: 7 pages, 2 figures
title: Replication code availability over time and across fields: Evidence from the German Socio-Economic Panel
Creators: name: Fink, Lukas
name: Marcus, Jan
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: code availability
subject: journal policies
subject: replication code
subject: reproducibility
subject: SOEP
classificationCode: 330
subject: Wirtschaft

description: Providing replication code is an inexpensive way to facilitate reproducibility. However, little is known about the extent of replication code provision. Therefore, we examine the availability of replication code for over 2500 peer-reviewed articles based on the German Socio-Economic Panel (SOEP), one of the most widely used datasets in economics and other social sciences. We find that only 6% of SOEP-based studies have code available, but that this proportion has increased sharply over time. We provide evidence that the increase in code provision is driven by technological advances, individual researcher initiatives, and journal policies.
Additional file 2 of A scoping review of perceptions from healthcare professionals on antipsychotic prescribing practices in acute care settings
Creators: name: Jaworska, Natalia
name: Moss, Stephana J.
name: Krewulak, Karla D.
name: Stelfox, Zara
name: Niven, Daniel J.
name: Ismail, Zahinoor
name: Burry, Lisa D.
name: Fiest, Kirsten M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2.
title: Not one inconvenient truth, but many: emergency narratives and climate change
Creators: name: Partzsch, Lena
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Authoritarianism
subject: climate change
subject: democracy
subject: emergency narrative
subject: power
classificationCode: 320
subject: Politikwissenschaft

description: A crisis is a decisive moment that can provide an opportunity for a change, but also reaffirm power asymmetries. This conceptual article highlights the Janus-faced character of declaring a climate emergency. More than 2,300 municipalities worldwide have done so. On the one hand, climate crisis and emergency narratives imply a disruption in which the dominant economic system is collectively challenged, enabling citizens to exercise power with others for greater sustainability. On the other hand, climate knowledge is often perceived as conclusive, paving the way for greater power over citizens and towards authoritarianism.
title: National biodiversity data infrastructures: ten essential functions for science, policy, and practice
Creators: name: Güntsch, Anton
name: Overmann, Jörg
name: Ebert, Barbara
name: Bonn, Aletta
name: Le Bras, Yvan
name: Engel, Thore
name: Hovstad, Knut Anders
name: Lange Canhos, Dora Ann
name: Fichtmueller, David
name: Luther, Katja
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: biodiversity data
subject: CBD
subject: data mobilization
subject: open data
subject: biodiversity informatics
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Today, at the international level, powerful data portals are available to biodiversity researchers and policymakers, offering increasingly robust computing and network capacities and capable data services for internationally agreed-on standards. These accelerate individual and complex workflows to map data-driven research processes or even to make them possible for the first time. At the national level, however, and alongside these international developments, national infrastructures are needed to take on tasks that cannot be easily funded or addressed internationally. To avoid gaps, as well as redundancies in the research landscape, national tasks and responsibilities must be clearly defined to align efforts with core priorities. In the present article, we outline 10 essential functions of national biodiversity data infrastructures. They serve as key providers, facilitators, mediators, and platforms for effective biodiversity data management, integration, and analysis that require national efforts to foster biodiversity science, policy, and practice.
On the Calibration of Full-polarization 86GHz Global VLBI Observations
Creators: name: Marti-Vidal, I.
name: Krichbaum, T. P.
name: Marscher, A.
name: Alef, W.
name: Bertarini, A.
name: Bach, U.
name: Schinzel, F. K.
name: Rottmann, H.
name: Anderson, J. M.
name: Zensus, J. A.
name: Bremer, M.
name: Sanchez, S.
name: Lindqvist, M.
name: Mujunen, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report the development of a semi-automatic pipeline for the calibration of 86 GHz full-polarization observations performed with the Global Millimeter-VLBI array (GMVA) and describe the calibration strategy followed in the data reduction. Our calibration pipeline involves non-standard procedures, since VLBI polarimetry at frequencies above 43 GHz is not yet well established. We also present, for the first time, a full-polarization global-VLBI image at 86 GHz (source 3C 345), as an example of the final product of our calibration pipeline, and discuss the effect of instrumental limitations on the fidelity of the polarization images. Our calibration strategy is not exclusive for the GMVA, and could be applied on other VLBI arrays at millimeter wavelengths. The use of this pipeline will allow GMVA observers to get fully-calibrated datasets shortly after the data correlation.
description: 10 pages, 10 figures. Accepted for publication in A&A
title: Efficacy of 0.2% povidone-iodine and 0.1% polyhexamethylene biguanide as preoperative antiseptics in equine ophthalmic procedures
Creators: name: Farkas, Anna
name: Thieme, Katharina
name: Soimala, Tanawan
name: Jensen, Charlotte K.
name: Eule, J. Corinna
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: antisepsis
subject: horse
subject: ocular surface
subject: PI
subject: polyhexanide
subject: preoperative disinfection
classificationCode: 630
subject: Landwirtschaft und verwandte Bereiche

description: Objective This retrospective study evaluates the efficacy of povidone-iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures. Animals Studied Horses that underwent routine ophthalmic surgery and procedures. Procedures Data were collected retrospectively from the medical records of equine patients undergoing ophthalmic procedures. Inclusion criteria were sampling for aerobic microbial culture at three different time points (T0: pre-irrigation, T1: post-irrigation, and T2: postoperatively) and T0 showing bacterial growth. Microbiological outcomes were assessed semi-quantitatively by creating a scoring system to describe the bacterial load. Furthermore, the species detected were evaluated. Poisson regression analysis was performed to evaluate the efficacy of the disinfectants. Results Eighty eyes (75 horses) met the inclusion criteria, with 36 cases being aseptically prepared with PI and 44 with PHMB. Both antiseptics significantly reduced the bacterial load and number of bacterial species (p < .001) between time points T0 and T1, and T0 and T2. PHMB showed a reduction in the bacterial load by 64% (CI: 51%–73%) whereas PI reduced it by 48% (CI: 36%–58%) between time points T0 and T1. The reduction in the number of bacterial species between time points T0 to T1 was significantly greater in the PHMB group (85%, CI: 70%–93%), compared to PI (47%, CI: 26%–62%). Conclusion Both PHMB and PI reduced the bacterial load and number of species on the ocular surface and eyelids significantly, with 0.1% PHMB being superior to 0.2% PI. Therefore, PHMB can be considered as a good alternative in preoperative antisepsis in equine ophthalmic procedures.
Long-term optical variability of PKS 2155-304
Creators: name: Kastendieck, Max A.
name: Ashley, Michael C. B.
name: Horns, Dieter
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Aims: The optical variability of the blazar PKS 2155-304 is investigated to characterise the red noise behaviour at largely different time scales from 20 days to O(>10 yrs). Methods: The long-term optical light curve of PKS 2155-304 is assembled from archival data as well as from so-far unpublished observations mostly carried out with the ROTSE-III and the ASAS robotic telescopes. A forward folding technique is used to determine the best-fit parameters for a model of a power law with a break in the power spectral density function (PSD). The best-fit parameters are estimated using a maximum-likelihood method with simulated light curves in conjunction with the Lomb Scargle Periodogram (LSP) and the first-order Structure Function (SF). In addition, a new approach based upon the so-called Multiple Fragments Variance Function (MFVF) is introduced and compared to the other methods. Simulated light curves have been used to confirm the reliability of these methods as well as to estimate the uncertainties of the best-fit parameters. Results: The light curve is consistent with the assumed broken power-law PSD. All three methods agree within the estimated uncertainties with the MFVF providing the most accurate results. The red-noise behaviour of the PSD in frequency f follows a power law with f^-β, β=1.8 +0.1/-0.2 and a break towards f^0 at frequencies lower than f_min=(2.7 +2.2/-1.6 yrs)^-1.
description: 10 pages, 8 figures, the ROTSE-light curve can be downloaded from http://vizier.cfa.harvard.edu/viz-bin/VizieR?-source=J/A+A/531/A123
Additional file 3 of A scoping review of perceptions from healthcare professionals on antipsychotic prescribing practices in acute care settings
Creators: name: Jaworska, Natalia
name: Moss, Stephana J.
name: Krewulak, Karla D.
name: Stelfox, Zara
name: Niven, Daniel J.
name: Ismail, Zahinoor
name: Burry, Lisa D.
name: Fiest, Kirsten M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Supplementary Table 1. Search strategy used in MEDLINE. Supplementary Table 2. Characteristics of included studies. Supplementary Table 3. Antipsychotic reported outcomes of included studies. Supplementary Table 4. Reportedantipsychotic medication prescribing indications included studies by acute care setting. Supplementary Table 5. Measured and perceived antipsychotics prescribed and prescribing indications reported for included studies, by acutecare setting. Supplementary Table 6. Number of studies reporting on healthcare professional reported perceived antipsychotic prescribing practices in acute care, by acute care setting and antipsychotic type. Supplementary Table 7. Number of studies reporting on measured outcomes of antipsychotic prescribing practices in the acute care setting, by acute care setting and antipsychotic type. Supplementary Table 8. Reported additionally prescribed sedative hypnotic medications for included studies reporting on antipsychotic medication prescribing, by acute care setting. Supplementary Table 9. Reported co-prescribed sedative hypnotic medications with antipsychotic medications for included studies which report on additionally prescribed medications, by acute care setting. Supplementary Table 10. Domains and constructs according to the Theoretical Domains Framework of perspectives on antipsychotic prescribing from healthcare professionals for included studies, by acute care setting. Supplementary Table 11. Deductive thematic analysis using the Theoretical Domains Framework on perceptions on antipsychotic prescribing forincluded studies. Supplementary Table 12. Description of reported antipsychotic deprescribing strategies applied in parallel for included studies reporting on antipsychotic medication prescribing.
Additional file 1 of Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis
Creators: name: Khattab, Ahmed
name: Torkamani, Ali
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Q–Q plots: (A) Diabetic Kidney Disease (DKD). (B) eGFR measurement in T2D. (C) eGFR measurement in non-diabetic (no T1D or T2D) individuals. λ = genomic inflation factor. Figure S2 Tissue enrichment analysis of the diabetic kidney disease (DKD) meta-analysis showing the levels of both up-regulated and down-regulated differentially expressed genes (DEG) in various tissues. Significant enrichment level is Bonferroni corrected P-value ≤ 0.05. Figure S3 GWAS Catalog reported genes: showing genes, from the diabetic kidney disease (DKD) meta-analysis, reported by the GWAS Catalog.
Hypergeometric solutions to Schrödinger equations for the quantum Painlevé equations
Creators: name: Nagoya, Hajime
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider Schrödinger equations for the quantum Painlevé equations. We present hypergeometric solutions of the Schrödinger equations for the quantum Painlevé equations, as particular solutions. We also give a representation theoretic correspondence between Hamiltonians of the Schrödinger equations for the quantum Painlevé equations and those of the KZ equation or the confluent KZ equations.
description: 17 pages; Journal of Mathematical Physics (Vol.52, Issue 8) 2011
Verborgene Wahrheit. Untersuchung des Verhältnisses von QAnon zu Religion auf Twitter
Creators: name: Hartmann, Daria
Publisher: name: Zenodo
Year: 2022
Subjects: QAnon
Religion
Tweitter
Topic Modeling
Netzwerkanalyse
Diskursanalyse

description: Verborgene Wahrheit. Untersuchung des Verhältnisses von QAnon zu Religion auf Twitter
When is region crossing change an unknotting operation?
Creators: name: Cheng, Zhiyun
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In this paper, we prove that region crossing change on a link diagram is an unknotting operation if and only if the link is proper. A description of the behavior of region crossing change on link diagrams is given. Furthermore we also discuss the relation between region crossing change and the Arf invariant of proper links.
description: 10 pages, 7 figures
Long-time series, small-area statistics for sustainable transport
Creators: name: Morgan, M
name: Philips, I
Publisher: name: Zenodo
Year: 2023

description: Transport policy often suffers from a paucity of data on which to build a robust evidence base. Long-time series, small-area transport statistics over a large geographical area can provide insights into the effects of a broad range of transport policies. Unfortunately there are important gaps in the UK’s small-area statistics that limit their usability and effectiveness for answering key policy questions. This paper reviews the state of data in the UK and reports early progress on filling data gaps.
On the entropy of decoherence matrix for quantum walks
Creators: name: Konno, Norio
name: Segawa, Etsuo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The decoherence matrix studied by Gudder and Sorkin (2011) can be considered as a map from the set of all the pairs of $n$-length paths to complex numbers, which is induced by the discrete-time quantum walk. The decoherence matrix is one of the decoherence functionals which present their historical quantum measure theory. In this paper, we compute the von Neumann entropy of the decoherence matrix. To do so, we use the result that the eigensystem of the decoherence matrix can be expressed by a corresponding correlated random walk.
description: 9 pages
title: "Ritratto di Domizia Lucilla, su busto moderno", arte romana, inv. CCXXXXIII (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Ciccarello, Giulia
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di

Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en