cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BEYOND DEADLY SINS AND VIRGIN IMPAIRMENTS: MEDIEVAL BODIES IN DISABILITY STUDIES
Creators: name: Roders, Dana M
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: British and Irish literature
Literary theory
British history

description: While the medieval lexicon did not include a comprehensive term for disability as we understand it today, images of impaired and disabled bodies proliferate in Middle English texts. This dissertation investigates textual representations of the material body across some of the most popular genres of the later Middle Ages (religious exempla, confessional literature, and hagiography) to demonstrate how medieval authors implement impaired bodies in service of spiritual exploration. I show how impaired medieval bodies that are often excluded from discussions of disability—for instance, personified sins, aging bodies, and martyrs’ bodies—are represented in distinctly material terms, drawing attention to medieval authors’ complex and nuanced explorations of bodily difference. Through sustained close readings and attention to medieval authors’ engagement with their source texts, I find that the impaired body operates as a generative site for engagement with significant ontological questions of the period —and that these textual depictions ultimately reveal the body’s resistance to easy or straightforward categorization. Moreover, my research demonstrates the utility of a more nuanced disability studies approach to medieval literature, intervening in current discussions about the ethics of applying the lens of disability to historical texts.
Additional file 9 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 9.: Metabolism map of AαC A representation of the filtered metabolism map of AαC with chemical structures.
Instrumental variables selection : a comparison between regularization and post-regularization methods
Creators: name: Di Gravio, Chiara
Publisher: name: University of British Columbia
Year: 2015

description: Instrumental variables are commonly used in statistics, econometrics, and epidemiology to obtain consistent parameter estimates in regression models when some of the predictors are correlated with the error term. However, the properties of these estimators are sensitive to the choice of valid instruments. Since in many applications, valid instruments come in a bigger set that includes also weak and possibly irrelevant instruments, the researcher needs to select a smaller subset of variables that are relevant and strongly correlated with the predictors in the model. This thesis reviews part of the instrumental variables literature, examines the problems caused by having many potential instruments, and uses different variables selection methods in order to identify the relevant instruments. Specifically, the performance of different techniques is compared by looking at the number of relevant variables correctly detected, and at the root mean square error of the regression coefficients’ estimate. Simulation studies are conducted to evaluate the performance of the described methods.
Characteristics of transposable element exonization within human and mouse
Creators: name: Sela, Noa
name: Mersch, Britta
name: Hotz-Wagenblatt, Agnes
name: Ast, Gil
Publisher: name: arXiv
Year: 2010
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons, an event called exonization. Elucidation of the evolutionary constraints that have shaped fixation of transposed elements within human and mouse protein coding genes and subsequent exonization is important for understanding of how the exonization process has affected transcriptome and proteome complexities. Here we show that exonization of transposed elements is biased towards the beginning of the coding sequence in both human and mouse genes. Analysis of single nucleotide polymorphisms (SNPs) revealed that exonization of transposed elements can be population-specific, implying that exonizations may enhance divergence and lead to speciation. SNP density analysis revealed differences between Alu and other transposed elements. Finally, we identified cases of primate-specific Alu elements that depend on RNA editing for their exonization. These results shed light on TE fixation and the exonization process within human and mouse genes.
description: 11 pages, 4 figures
The role of hydrology, geochemistry and microbiology in flow and solute transport through highly heterogeneous, unsaturated waste rock at various test scales
Creators: name: Blackmore, Sharon
Publisher: name: University of British Columbia
Year: 2015

description: Drainage chemistries from unsaturated waste rock are affected by a number of hydrological, geochemical and microbiological processes. These processes are generally coupled and reliable prediction of solute loads is a difficult task for most mine sites, making it challenging to provide accurate estimates of future water treatment requirements. An assessment of preferential and matrix flow, geochemical controls and microbially-enhanced weathering is beneficial to provide an improved understanding of the dominant drainage controls. A multi-scale waste rock study was implemented at the Antamina mine (Peru) to assess drainage controls using 10-m high pile experiments, 1-m field barrels and 0.8-m laboratory columns. Observed drainage chemistries show a strong seasonal pattern in response to changes in infiltration rates, with increasing concentrations during the dry season and decreasing concentrations during the wet season. These seasonal fluctuations are less pronounced for finer-grained material, likely due to lower proportions of preferential flow, indicating that hydrological processes provide a key control on observed drainage chemistries. Microbiological analyses show iron-oxidizing neutrophiles are ubiquitous to all rock types, whereas proportions of acidophiles are strongly influenced by lithology. Drainage waters are more acidic and contain higher metal loads with increasing proportions of acidophilic microbes. Breakthrough curves of an externally-applied bromide tracer show that infiltration migrates mostly through matrix materials, with a minor proportion following preferential flow paths. Long tails indicate a portion of mass enters extremely slow matrix flow paths and/or immobile domains. Chloride, originating from blasting residues, was used as an internal tracer. Mean residence times from chloride breakthroughs are longer than bromide values for the same spatially-specific region, suggesting a slow release of chloride from low permeability matrix material. Flow and solute transport processes were successfully modeled using a dual-porosity mobile-immobile approach in HYDRUS1D. This research provides an improved understanding of the governing hydrologic and geochemical processes relevant to Antamina waste rock with implications for the large-scale waste rock dumps at site. Other aspects of this research, such as using blasting residues as an internally-applied tracer and using a dual-domain approach to model flow and solute transport, will be of value to other mines with similar conditions.
Low-temperature photocarrier dynamics in monolayer MoS2
Creators: name: Korn, T.
name: Heydrich, S.
name: Hirmer, M.
name: Schmutzler, J.
name: Schüller, C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The band structure of MoS$_2$ strongly depends on the number of layers, and a transition from indirect to direct-gap semiconductor has been observed recently for a single layer of MoS$_2$. Single-layer MoS$_2$ therefore becomes an efficient emitter of photoluminescence even at room temperature. Here, we report on scanning Raman and on temperature-dependent, as well as time-resolved photoluminescence measurements on single-layer MoS$_2$ flakes prepared by exfoliation. We observe the emergence of two distinct photoluminescence peaks at low temperatures. The photocarrier recombination at low temperatures occurs on the few-picosecond timescale, but with increasing temperatures, a biexponential photoluminescence decay with a longer-lived component is observed.
description: 3 pages, 4 figures
Ohmic Dissipation in the Atmospheres of Hot Jupiters
Creators: name: Perna, Rosalba
name: Menou, Kristen
name: Rauscher, Emily
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Hot Jupiter atmospheres exhibit fast, weakly-ionized winds. The interaction of these winds with the planetary magnetic field generates drag on the winds and leads to ohmic dissipation of the induced electric currents. We study the magnitude of ohmic dissipation in representative, three-dimensional atmospheric circulation models of the hot Jupiter HD 209458b. We find that ohmic dissipation can reach or exceed 1% of the stellar insolation power in the deepest atmospheric layers, in models with and without dragged winds. Such power, dissipated in the deep atmosphere, appears sufficient to slow down planetary contraction and explain the typically inflated radii of hot Jupiters. This atmospheric scenario does not require a top insulating layer or radial currents that penetrate deep in the planetary interior. Circulation in the deepest atmospheric layers may actually be driven by spatially non-uniform ohmic dissipation. A consistent treatment of magnetic drag and ohmic dissipation is required to further elucidate the consequences of magnetic effects for the atmospheres and the contracting interiors of hot Jupiters.
description: Accepted to the Astrophysical Journal
БІЛІМ БЕРУДЕГІ ВИРТУАЛДЫ ШЫНДЫҚ
Creators: name: Абильдинова Г.М.
name: Мухтарқызы К.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: виртуалды шындық
виртуалды орта
VR
білім
конструктивистік
қабылдау және әрекет.

description: Күнделікті оқытуда ең озық технологияларды қолдану маңызды деген ой қазіргі зерттеушілердің ғана емес, барлығымыздың дерлік ойларымыздан кетпейді. Тіл білімі мен психология саласындағы мамандардың пікірінше, жаңа білімді игерудің ең қолайлы шарттары балалық және жасөспірімдік шақ. Бірақ қызығушылықтың жетіспеушілігі, шашыраңқылық және қиын нәрселерге шоғырлана алмау кез келген жаста тиімді білім алуға мүмкіндік бермейді. Қазіргі білім беру жүйесі ойын-сауық саласымен бәсекелес және студенттерді жаңа білімді игеру үдерісіне тартатын қабылдау тетіктерін қажет етеді. Ақыр соңында, тиімді оқыту қызығушылыққа негізделген, оны алдымен қалыптастыру керек, содан кейін оны қолдау қажетекендігін көрсетеді. Тек ХХІ ғасырда студенттерді суреттермен баурап алу, ескі фильмдерді көру немесе тез ескірген әдебиеттерді оқу мүмкін емес. Сондықтан VR және AR қолдауы бар құрылғылар бүгінде білім беруде танымал бола түсуде. Білім берудегі AR және VR форматтары әртүрлі болуы мүмкін, бірақ олардың бетпе-бет оқытудан артықшылығы айқын. Тәжірибе мен суреттерді виртуалды және толықтырылған шындық арқылы беру, ең алдымен, тартудың тиімділігіне, демек, білім беру үдерісін жақсартуға мүмкіндік береді. Мұнда біз мульти-сенсорлық визуалдау мен интерактивтіліктің үйлесімділігін виртуалды шындықты тиімді оқуға қалай сәйкес келтіруге болатынын қарастырамыз және осы тиімділікті тәжірибелерден алынған белсенді оқытудың артықшылықтары тұрғысынан түсіндіруге тырысамыз. Біз сондай-ақ VR-дің білім берудегі кейбір қосымшаларын және осы технологиямен байланысты кемшіліктерін қарастырамыз.
ДОКУМЕНТИРОВАНИЕ ХОЗЯЙСТВЕННЫХ ОПЕРАЦИЙ
Creators: name: Марченко В. Г.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: хозяйственные операции
документы
бухгалтерский учет
реквизиты
первичный учет.

description: В статье рассматривается документирование хозяйственных операций, как основа бухгалтерского учета. Данная тема актуальна, так как от правильного ведения документооборота зависит успех орга-низации. Также акцентируется внимание на Регистрацию свершившихся фактов хозяйственной дея-тельности учреждения, осуществляемая в установленном законом порядке.
Experimental Approaches to Advance Hellbender Headstarting
Creators: name: Royal, Shelby Monet
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Other agricultural, veterinary and food sciences not elsewhere classified

description: The Eastern Hellbender (Cryptobranchus alleganiensis alleganiensis) is a fully aquatic salamander found throughout the eastern United States. Hellbenders require cool, fast-moving rivers and streams with flat rock substrates for shelter. Due to habitat degradation and anthropogenic changes across landscapes, Hellbenders have required intervention programs to reduce extirpation and extinction risks. Over 5000 Hellbenders are found in captive-rearing and breeding programs throughout 15 different states. However, captive-rearing standards vary from facility to facility. Currently, Hellbender captive-rearing programs are based on established zoo guidelines that recommend rearing in traditional glass aquaria until they reach releasable mass (~60 g) at approximately three years of age. To achieve releasable size, the guidelines provide density and food availability requirements based on the amount of available floor space of the enclosure. Unfortunately, because these guidelines lack empirical data, it is unclear whether these recommendations are optimizing captive-rearing efforts for Hellbenders and, therefore, optimizing conservation potential. There is an overall lack of available information on housing conditions and requirements for Hellbenders outside of intraspecies aggression or cannibalism. Because many facilities use different types of housing conditions, there is substantial variation in the time needed to achieve the release size threshold. Our objectives were to: 1) understand how different raceway sizes impact growth rates of juvenile Hellbenders and 2) understand the effects of density and food availability on larval Hellbender growth. Both of these goals will allow us to develop optimal housing and husbandry standards and optimizing conservation potential within rearing facilities. Our study will build on our current knowledge of Hellbender captive-rearing techniques and provide empirical data to create optimal rearing standards nationwide.
Assessment of stiffness in intact cartilage using contrast-enhanced computed tomography (CECT)
Creators: name: Nickmanesh, Reza
Publisher: name: University of British Columbia
Year: 2016

description: Introduction: Osteoarthritis (OA) is the most prevalent joint disease in Canada, affecting millions of people. OA begins with softening of cartilage and is characterized by progressive loss of the tissue resulting in joint impairment. Because cartilage’s primary function is mechanical, and because OA disrupts cartilage’s mechanical function, there is a substantial need for a non-invasive method to assess cartilage mechanics. Contrast-enhanced computed tomography (CECT) using charged contrast agents is an imaging method developed to quantify Glycosaminoglycan (GAG) content of cartilage. Since GAG is a key determinant of cartilage compressive stiffness, CECT measurements may be correlated with cartilage stiffness. The objective of this study was to determine whether CECT using a novel cationic contrast agent (CA4+) is correlated with cartilage stiffness in intact human joint surfaces. Methods: Six human femoral condyle compartments with intact healthy cartilage (ICRS grade 0 or 1) were used. Cartilage stiffness was measured across the surface in a Mach-1 testing system (Biomomentum, Montreal) using an indentation test. The samples were then immersed in CA4+ solution for 48 hours and then scanned at 41μm resolution in a hr-pQCT scanner (Xtreme CT, Scanco, Zurich). The averages of CECT attenuations at the sites of the indentation tests were computed for both superficial cartilage (600μm depth) and for the full thickness of cartilage. Correlations between stiffness and CECT attenuation were assessed with scatter plots and Pearson’s correlation coefficient. Results: A significant and positive correlation was observed between stiffness data and mean CECT attenuations in superficial cartilage across all samples, with correlation coefficients ranging from r=0.4 to 0.72, and p<0.01. When data from all locations were pooled (n=221), the correlation coefficient was r=0.55 and a regression line fitted to the data predicted stiffness from CECT measurements with an error of 20% of the stiffness range. However, correlations between stiffness and CECT attenuations in full-depth cartilage were substantially lower and not significant in half of the tested specimens. CECT identified regions of reduced cartilage stiffness and the expected depth dependent changes in GAG concentration. Conclusion: CECT of superficial cartilage using CA4+ provides a surrogate measure of compressive cartilage stiffness in intact joint surfaces.
Ising model with varying spin strength on a scale-free network: scaling functions and critical amplitude ratios
Creators: name: Krasnytska, M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Recently, a novel model to describe ordering in systems comprising agents which, although matching in their binarity (i.e., maintaining the iconic Ising features of ``+'' or ``-'', ``up'' or ``down'', ``yes'' or ``no''), still differing in their strength was suggested [Krasnytska et al., J. Phys. Complex., 2020, 1, 035008]. The model was analyzed for a particular case when agents are located on sites of a scale-free network and agent strength is a random variable governed by a power-law decaying distribution. For the annealed network, the exact solution shows a rich phase diagram with different types of critical behavior and new universality classes. This paper continues the above studies and addresses the analysis of scaling functions and universal critical amplitude ratios for the model on a scale-free network.
description: 10 pages, 3 figures, 2 tables
3D video quality assessment
Creators: name: Banitalebi Dehkordi, Amin
Publisher: name: University of British Columbia
Year: 2016

description: A key factor in designing 3D systems is to understand how different visual cues and distortions affect the perceptual quality of 3D video. The ultimate way to assess video quality is through subjective tests. However, subjective evaluation is time consuming, expensive, and in most cases not even possible. An alternative solution is objective quality metrics, which attempt to model the Human Visual System (HVS) in order to assess the perceptual quality. The potential of 3D technology to significantly improve the immersiveness of video content has been hampered by the difficulty of objectively assessing Quality of Experience (QoE). A no-reference (NR) objective 3D quality metric, which could help determine capturing parameters and improve playback perceptual quality, would be welcomed by camera and display manufactures. Network providers would embrace a full-reference (FR) 3D quality metric, as they could use it to ensure efficient QoE-based resource management during compression and Quality of Service (QoS) during transmission. In this thesis, we investigate the objective quality assessment of stereoscopic 3D video. First, we propose a full-reference Human-Visual-system based 3D (HV3D) video quality metric, which efficiently takes into account the fusion of the two views as well as depth map quality. Subjective experiments verified the performance of the proposed method. Next, we investigate the No-Reference quality assessment of stereoscopic video. To this end, we investigate the importance of various visual saliency attributes in 3D video. Based on the results gathered from our study, we design a learning based visual saliency prediction model for 3D video. Eye-tracking experiments helped verify the performance of the proposed 3D Visual Attention Model (VAM). A benchmark dataset containing 61 captured stereo videos, their eye fixation data, and performance evaluations of 50 state-of-the-art VAMs is created and made publicly available online. Finally, we incorporate the saliency maps generated by our 3D VAM in the design of the state-of-the- art no-reference (NR) and also full-reference (FR) 3D quality metrics.
On the very high energy spectrum of the Crab pulsar
Creators: name: Chkheidze, N.
name: Machabeli, G.
name: Osmanov, Z.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In the present paper we construct a self-consistent theory, interpreting the observations of the MAGIC Cherenkov Telescope of the very high energy (VHE) pulsed emission from the Crab pulsar. In particular, on the basis of the Vlasov's kinetic equation we study the process of the quasi-linear diffusion(QLD) developed by means of the cyclotron instability. This mechanism provides simultaneous generation of low (radio) and VHE (0.01-25GeV) emission on the light cylinder scales, in one location of the pulsar magnetosphere. A different approach of the synchrotron theory is considered, giving the spectral index of VHE emission ($β=2$) and the exponential cutoff energy (23 GeV) in a good agreement with the observational data.
description: 8 pages, 0 figures
ИННОВАЦИИ В ТУРИЗМЕ. МАРКЕТИНГОВАЯ ПОЛИТИКА
Creators: name: Семёнов Максим Сергеевич
Publisher: name: Colloquium-journal
Year: 2020
Subjects: инновации
туристическая отрасль
инновационная деятельность
маркетинг
инновационная стратегия
предприятия туризма.

description: Статья посвящена изучению особенностей инноваций и инновационной деятельности в сфере ту-ризма. Формулируются факторы, оказывающее влияние на инновационную деятельность в туризме, называются принципы инновационной деятельности туристического предприятия. Как особое направ-ление инноваций в туризме рассматривается маркетинговая политика, которая позволяет сформиро-вать конкурентоспособную инновацию и внедрить её на рынок.
The Weinstein Conjecture for Hamiltonian Fibrations
Creators: name: Hyvrier, Clement
Publisher: name: arXiv
Year: 2011
Subjects: subject: Symplectic Geometry (math.SG)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 57R17, 53D45, 55R10

description: In this note we extend to non trivial Hamiltonian fibrations over symplectically uniruled manifolds a result of Lu's, \cite{Lu}, stating that any trivial symplectic product of two closed symplectic manifolds with one of them being symplectically uniruled verifies the Weinstein Conjecture for closed separating hypersurfaces of contact type, under certain technical conditions. The proof is based on the product formula for Gromov-Witten invariants ($GW$-invariant) of Hamiltonian fibrations derived in \cite{H}.
description: 15 pages
ИНТЕГРАЛЬНАЯ ОЦЕНКА ВНЕШНЕЭКОНОМИЧЕСКОЙ ДЕЯТЕЛЬНОСТИ ПРЕДПРИЯТИЯ
Creators: name: Малахова Ю.А.
name: Ильченко В.Ю.
name: Варварский В. А.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: economic efficiency
foreign economic activity
methods
integrated assessment
integrated indicators.

description: The article considers the methods of a comprehensive assessment of the economic condition of economic entities of different sectors of the economy and identifies their weaknesses and strengths. The obtained infor-mation is the basis for the selection of integrated indicators, assessment, and analysis of the level of efficiency of foreign economic activity of enterprises.
Effective phase description of noise-perturbed and noise-induced oscillations
Creators: name: Schwabedal, Justus T. C.
name: Pikovsky, Arkady
Publisher: name: arXiv
Year: 2010
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: An effective description of a general class of stochastic phase oscillators is presented. For this, the effective phase velocity is defined either by invariant probability density or via first passage times. While the first approach exhibits correct frequency and distribution density, the second one yields proper phase resetting curves. Their discrepancy is most pronounced for noise-induced oscillations and is related to non-monotonicity of the phase fluctuations.
ИСПОЛЬЗОВАНИЕ СОВРЕМЕННЫХ ИНФОРМАЦИОННЫХ ТЕХНОЛОГИЙ В ОБРАЗОВАТЕЛЬНОМ ПРОЦЕССЕ
Creators: name: Варфоломеева Лариса Евгеньевна
name: Круглова Елена Владимировна
Publisher: name: Colloquium-journal
Year: 2020
Subjects: образовательная организация
информационные технологии
дистанционное обучение
студент
система образования
физическая культура.

description: В статье приводятся результаты исследования использования в образовательном процессе по фи-зической культуре в образовательных организациях разного уровня современных информационных тех-нологий, применяемых при дистанционном обучении. Отмечается, что в реализуемой в существующей системе образования, мы наблюдаем существен-ное противоречие между необходимостью разработки новых современных педагогических технологий, способных интегрировать методики дистанционного обучения в существующую традиционную систему профессионального образования, и отсутствием научно-методических исследований и практически ис-пользуемых технологий, позволяющих совершенствовать методику преподавания физической культуры в образовательных заведениях разного уровня, а также отвечающих современным компетенциям и стандартам высшего образования. В образовательных организациях использование системы дистанци-онного обучения в физкультурном образовании студентов является незначительным и происходит очень настороженно. При этом, обучение всем разделам физической культуры осуществляется, преимущественно в рам-ках строго ограниченного количества очных занятий с преподавателем. Отсутствие обратной связи, систематического контроля в межсессионный период приводит к неэффективности самостоятельной работы студентов. Делается вывод о том, что на современном этапе в образовательных организациях в учебном про-цессе современные информационные методики дистанционного образования используются в ограничен-ном объеме, а методика применения комбинированной модели образовательного процесса, сочетающей дистанционные и традиционные формы, показала преобладание над применяемой только традиционной моделью построения образовательного процесса.
Additional file 1 of Mitigating selection bias in organ allocation models
Creators: name: Schnellinger, Erin M.
name: Cantu, Edward
name: Harhay, Michael O.
name: Schaubel, Douglas E.
name: Kimmel, Stephen E.
name: Stephens-Shields, Alisa J.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1.
High Performance Human Face Recognition using Independent High Intensity Gabor Wavelet Responses: A Statistical Approach
Creators: name: Kar, Arindam
name: Bhattacharjee, Debotosh
name: Basu, Dipak Kumar
name: Nasipuri, Mita
name: Kundu, Mahantapas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this paper, we present a technique by which high-intensity feature vectors extracted from the Gabor wavelet transformation of frontal face images, is combined together with Independent Component Analysis (ICA) for enhanced face recognition. Firstly, the high-intensity feature vectors are automatically extracted using the local characteristics of each individual face from the Gabor transformed images. Then ICA is applied on these locally extracted high-intensity feature vectors of the facial images to obtain the independent high intensity feature (IHIF) vectors. These IHIF forms the basis of the work. Finally, the image classification is done using these IHIF vectors, which are considered as representatives of the images. The importance behind implementing ICA along with the high-intensity features of Gabor wavelet transformation is twofold. On the one hand, selecting peaks of the Gabor transformed face images exhibit strong characteristics of spatial locality, scale, and orientation selectivity. Thus these images produce salient local features that are most suitable for face recognition. On the other hand, as the ICA employs locally salient features from the high informative facial parts, it reduces redundancy and represents independent features explicitly. These independent features are most useful for subsequent facial discrimination and associative recall. The efficiency of IHIF method is demonstrated by the experiment on frontal facial images dataset, selected from the FERET, FRAV2D, and the ORL database.
description: Keywords: Feature extraction; Gabor Wavelets; independent high-intensity feature (IHIF); Independent Component Analysis (ICA); Specificity; Sensitivity; Cosine Similarity Measure; E-ISSN: 2044-6004
The search for novel inhibitors of coactivator-associated arginine methyltransferase 1
Creators: name: Sedlock, Shona Anne
Publisher: name: University of British Columbia
Year: 2017

description: Coactivator-associated arginine methyltransferase 1 (CARM1) is a member of the protein arginine methyltransferase (PRMT) family of enzymes, and is also known as PRMT4. PRMTs catalyse the transfer of methyl groups from S-adenosyl-L-methionine (SAM) to the side chain of arginine residues in substrate proteins. The dysregulation of CARM1 contributes to the onset and progression of breast and prostate cancer. For this reason, CARM1 is a target for inhibition, yet CARM1 inhibitors to date either lack selectivity or fail to show anti-proliferative effects in cells. This work aims to identify novel small molecules that can be further developed to inhibit CARM1 activity in cancer cells. Using the crystal structure (2Y1X) of the CARM1 catalytic domain in complex with CMPD-2 and S-adenosyl-L-homocysteine as a model for downstream screening, a computer-aided drug discovery and design (CADD) pipeline was developed, enabling docking to identify novel inhibitors. Over 76,600 compounds alongside known CARM1 inhibitors were screened using the industry standard proprietary software suite Accelrys Discovery Suite 4.5®. LibDock and CDOCKER algorithms were deployed independently and in series. Subsequently, a P81 filter-binding assay assessed the top hits from the in silico screening for CARM1 inhibition in vitro to generate IC50 values. A lead CARM1 inhibitor, Diamine 12 was used as a positive control, which scored highly with LibDock and CDOCKER and had an IC50 value of 1.3±1 µM with the P81 filter-binding assay. Top-ranked hits identified using Accelrys® showed some binding interactions in the arginine-binding cavity yet little to no activity in vitro. The work here fundamentally addresses the development of a workflow that provides a platform for discovery consisting of in vitro and in silico screening methods. Future work will involve expanding on the findings here to identify novel CARM1 inhibitors to be developed into therapeutic agents for the treatment of breast and prostate cancers.
Consensus decision making on a complete graph: complex behaviour from simple assumptions
Creators: name: Sarkanych, P.
name: Sevinchan, Yu.
name: Krasnytska, M.
name: Romanczuk, P.
name: Holovatch, Yu.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this paper we investigate a model of consensus decision making [Hartnett A. T., et al., Phys. Rev. Lett., 2016, 116, 038701] following a statistical physics approach presented in [Sarkanych P., et al., Phys. Biol., 2023, 20, 045005]. Within this approach, the temperature serves as a measure of fluctuations, not considered before in the original model. Here, we discuss the model on a complete graph. The main goal of this paper is to show that an analytical description may lead to a very rich phase behaviour, which is usually not expected for a complete graph. However, the variety of individual agent (spin) features - their inhomogeneity and bias strength - taken into account by the model leads to rather non-trivial collective effects. We show that the latter may emerge in a form of continuous or abrupt phase transitions sometimes accompanied by re-entrant and order-parameter flipping behaviour. In turn, this may lead to appealing interpretations in terms of social decision making. We support analytical predictions by numerical simulation. Moreover, while analytical calculations are performed within an equilibrium statistical physics formalism, the numerical simulations add yet another dynamical feature - local non-linearity or conformity of the individual to the opinion of its surroundings. This feature appears to have a strong impact both on the way in which an equilibrium state is approached as well as on its characteristics.
description: 14 pages, 8 figures
Kinetics of leaching of covellite in ferric-sulfate-sulfuric acid media
Creators: name: Angeles, Carlos
Publisher: name: University of British Columbia
Year: 2015

description: Hydrometallurgy methods to extract copper are becoming more frequently applied in modern industry. However, the leaching kinetics for certain minerals like covellite is poorly understood. This thesis investigates the kinetics of covellite leaching in a ferric-sulfate-sulfuric acid media, with an emphasis first placed on the understanding of the effect of the most common variables such as temperature and redox potential. A natural mineral sample of covellite and an ore sample from the Oyu Tolgoi project in Mongolia were obtained for the leaching studies. The leaching temperature was varied from 20° to 90°C, the total iron concentration varied from 0.1 mol/L to 0.5 mol/L, the Fe+³/Fe+² ratios varied from 0.1 to 10. The leaching results showed that an increase in temperature will result in an increase in the rate and extent of copper extraction. However, the redox potential or Fe+³/Fe+² ratio have little to no effect on the final copper extraction. These factors had only a modest impact on copper leach kinetics. The final copper extractions for covellite from Butte, Montana and covellite containing ore from Oyu Tolgoi at the same temperature were very similar. The key factor to improve copper extraction from covellite containing ores is to maximize the leach temperature. The other factors appear to be much less important. These findings provide the basis for process design and optimization of industrial leaching processes of covellite.
Female representation across mythologies
Creators: name: Janickyj, M.
name: MacCarron, P.
name: Yose, J.
name: Kenna, R.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Social groups have been studied throughout history to understand how different configurations impact those within them. Along with this came the interest in investigating social groups of both fictional and mythological works. Over the last decade these social groups have been studied through the lens of network science allowing for a new level of comparison between these stories. We use this approach to focus on the attributes of the characters within these networks, specifically looking at their gender. With this we review how the female populations within various narratives and to some extent the societies they are based in are portrayed. Through this we find that although there is not a trend of all narratives of the same origin having similar levels of representation some are noticeably better than others. We also observe which narratives overall prioritise important female characters and which do not.
description: 12 pages, 4 tables
КАДРОВАЯ ПОЛИТИКА И ЕЕ ВЛИЯНИЕ НА ЭФФЕКТИВНОСТЬ РАБОТЫ КОМПАНИИ
Creators: name: Буден Д.А.
name: Воробьева Д.И.
name: Буден Е.Е.
name: Кравченко Е.И.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: эффективность
кадровая политика
эффективность работы компании.

description: В работе определены основные моменты понятия кадровая политика и эффективность, а также рассмотрено ее влияние на финансовый результат организации.
Figures of Merit for Testing Standard Models: Application to Dark Energy Experiments in Cosmology
Creators: name: Amara, Adam
name: Kitching, Thomas
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Given a standard model to test, an experiment can be designed to: (i) measure the standard model parameters; (ii) extend the standard model; or (iii) look for evidence of deviations from the standard model. To measure (or extend) the standard model, the Fisher matrix is widely used in cosmology to predict expected parameter errors for future surveys under Gaussian assumptions. In this article, we present a frame- work that can be used to design experiments such that it maximises the chance of finding a deviation from the standard model. Using a simple illustrative example, discussed in the appendix, we show that the optimal experimental configuration can depend dramatically on the optimisation approach chosen. We also show some simple cosmology calculations, where we study Baryonic Acoustic Oscillation and Supernove surveys. In doing so, we also show how external data, such as the positions of the CMB peaks measured by WMAP, and theory priors can be included in the analysis. In the cosmological cases that we have studied (DETF Stage III), we find that the three optimisation approaches yield similar results, which is reassuring and indicates that the choice of optimal experiment is fairly robust at this level. However, this may not be the case as we move to more ambitious future surveys.
description: Submitted to MNRAS. 12 pages, 9 figures
КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ ГИПЕРПАРАТИРЕОЗА И АДЕНОМЫ ПАРАЩИТОВИДНЫХ ЖЕЛЕЗ.
Creators: name: Стяжкина С.Н.
name: Филинова В.С.
name: Исмагилова А.А.
name: Исмагилова А.Д.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: хирургия
заболевание
аденомы
паращитовидные железы
гиперпаратиреоз

description: В данной статье рассматривается случай гиперпаратиреоза и аденомы паращитовидных желез. Гиперпаратиреоз – фиброзная остеодистрофия, заболевание паращитовидных желез, протекабщее с повышением их функции вследствие гиперплазии и опухолевого поражения желез. При ГПТ различного генеза имеет место имеет повышенная секреция паратгормона. Поскольку органами мишенями являют-ся почки и костная ткань, то наблюдается повышение уровня фосфора в моче и повышается уровень кальция в крови. По данным большинства авторов ГПТ встречается с частотой 1 : 1000 человек, жен-щины болеют в 2-3 раза чаще, чем мужчины. ГПТ чаще встречается у людей 20-50 лет. Преимуществен-но причиной ГПТ являются аденомы паращитовидных желез, как одиночная, так и множественная. Аде-нома паращитовидной железы – доброкачественная опухоль паращитовидной железы, вырабатываю-щая паратгормон. При формировании аденомы происходит мутация рецептора на поверхности клеток паращитовидной железы, которая делает рецептор нечувствительным к концентрации ионизированно-го кальция в сыворотке крови. Вследствие подобной мутации рецептор постоянно сигнализирует клет-ке о том, что кальция в крови недостаточно, и клетка паращитовидной железы начинает бесконтроль-но и постоянно вырабатывать паратгормон. Повышение концентрации паратгормона в крови приво-дит к повышению уровня кальция выше нормальных пределов – эта комбинация лабораторных призна-ков является основным симптомом аденомы паращитовидной железы, на основании выявления которой и устанавливается диагноз в большинстве случаев.
НОВЫЕ МЕТОДЫ ЭКСПЕРИМЕНТАЛЬНОЙ ГАЗОГИДРОДИНАМИКИ И ИХ РОЛЬ В РАЗВИТИИ ТЕХНИЧЕСКИХ ИННОВАЦИЙ
Creators: name: Тимур Игоревич Зарубин
name: Ариадна Романовнна Луковникова
Publisher: name: Colloquium-journal
Year: 2020
Subjects: Hydrodynamics
experimental methods
sensors
turbulence
aerospace systems
gas dynamics

description: В статье показывается возможность применения системы прецизионных датчиков, для исследова-ния параметров турбулентного потока сплошной среды, а так же возможности её применения для ре-шения инженерно-прикладных задач проектирования аэрокосмических систем.
Performance assessment of short-term hydrological forecasts in small, coastal watersheds with complex terrain using fully-distributed hydrological and meteorological models
Creators: name: VanWerkhoven, Curtis
Publisher: name: University of British Columbia
Year: 2015

description: Accurate and reliable short-term streamflow forecast systems are beneficial for non-storage hydroelectric operators to minimize costs associated with foregoing electricity market opportunities because of held reserves due to forecast error and those making decisions based on flood risks. Accurate real-time forecasting on hourly and daily intervals with lead times less than three days remains a challenge in small, coastal, mountainous watersheds of the Pacific Northwest. This thesis examines a real-time streamflow forecasting system in which a physically-based, fully-distributed coupled MIKE SHE/MIKE 11 hydrologic model is driven by the distributed output of a 1.3 km gridded high-resolution numerical weather prediction (NWP) model. The model performance in simulating hydrological processes is evaluated in the model calibration and validation phases, and the forecast accuracy and reliability is evaluated in the forecast verification phase. Both performance evaluations are completed with graphical and statistical techniques based on a wide range of statistical metrics. In addition to the performance, the forecast skill is evaluated relative to alternative reference forecasts including persistence and historical climatological forecasts. The hydrologic model and forecasting system are applied to the Coquitlam River above Coquitlam Lake watershed located in the coastal mountains of southwestern British Columbia, Canada. The hydro-climate regime in the watershed is pluvio-nival, flashy, and with negligible glacier melt. High flows have a bi-modal distribution, characterized by high flows in May and June due to snowmelt and in fall (November) due to Pacific frontal systems that can bring significant precipitation. The MIKE SHE/MIKE 11 model performs well during the model calibration and validation phases, demonstrating accuracy and reliability in simulating the hydrological processes in the watershed with a one year calibration period. In addition, the forecast system provides a reliable forecast for hourly and daily mean streamflow with considerable forecast skill in comparison to reference forecasts for lead times of one to three days. MIKE SHE/MIKE 11 is demonstrated as a suitable fully-distributed, physically-based model for river forecasts based on high-resolution NWP models, and that there is the opportunity for short-term forecast skill in small, mountainous, Pacific Northwest watersheds with limited observed data.
On the Topology of Symmetric Semialgebraic Sets
Creators: name: Rosenblum, Alison M
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Algebraic and differential geometry
Mathematical logic, set theory, lattices and universal algebra

description: This work strengthens and extends an algorithm for computing Betti numbers of symmetric semialgebraic sets developed by Basu and Riener in, Vandermonde Varieties, Mirrored Spaces, and the Cohomology of Symmetric Semi-Algebraic Sets. We first adapt a construction of Gabrielov and Vorobjov in, Approximation of Definable Sets by Compact Families, and Upper Bounds on Homotopy and Homology, for replacing arbitrary definable sets by compact ones to the symmetric case. The original construction provided maps from the homotopy and homology groups of the replacement set to those of the original; we show that for sets symmetric relative to the action of some finite reflection group G, we may construct these maps to be equivariant. This modification to the construction for compact replacement allows us to extend Basu and Riener's theorem on which submodules appear in the isotypic decomposition of each cohomology space to sets not necessarily closed and bounded. Furthermore, by utilizing this equivariant compact approximation, we may obtain a precise description of the aforementioned decomposition of each cohomology space, and not merely the final dimension of the space, from Basu and Riener's algorithm.
 Though our equivariant compact replacement holds for G any finite reflection group, Basu and Riener's results only consider the case of the action the of symmetric group, sometimes termed type A. As a first step towards generalizing Basu and Riener's work, we examine the next major class of symmetry: the action of the group of signed permutations (known as type B). We focus our attention on Vandermonde varieties, a key object in Basu and Riener's proofs. We show that the intersection of a type B Vandermonde variety with a fundamental region of type B symmetry is topologically regular. We also prove a result about the intersection of a type B Vandermonde variety with the walls of this fundamental region, leading to the elimination of factors in a different decomposition of the homology spaces.
Modeling branching effects on source-sink relationships of the cotton plant
Creators: name: Li, Dong
name: Letort, Véronique
name: Guo, Yan
name: De Reffye, P.
name: Zhan, Zhigang
Publisher: name: arXiv
Year: 2010
Subjects: subject: Dynamical Systems (math.DS)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Mathematics
subject: FOS: Biological sciences

description: Compared with classical process-based models, the functional-structural plant models provide more efficient tools to explore the impact of changes in plant structures on plant functioning. In this paper we investigated the effects of branches on the sourcesink interaction for the cotton plant (Gossypium hirsutum L.) based on a two-treatment experiment conducted on cotton grown in the field: the singlestem plants and the plants with only two vegetative branches. It was observed that the branched cotton had more organs for the whole plant but the organs on the trunk were smaller than those on the single-stem cotton. The phytomer production of the branches was four or five growth cycles delayed compared with the main stem. The organs on the trunk had similar dynamics of expansion for both treatments. Effects of branches were evaluated by using the functionalstructural model GREENLAB. It allowed estimating the coefficients of sink strength to differentiate the biomass acquisition abilities of organs between different physiological ages. We found that the presence of the two vegetative branches increased the ground projection area of plant leaves and had led to slight changes on the directly measured parameters; the potential relative sink strengths of organs were found similar for the two treatments.
Additional file 2 of Antithrombotic therapy in coronary artery disease patients with atrial fibrillation
Creators: name: Wei, Lili
name: Su, Enyong
name: Liu, Weili
name: Xing, Wenlu
name: Liu, Xinyun
name: Zhang, You
name: Wang, Shan
name: Cheng, Qianqian
name: Qi, Datun
name: Gao, Chuanyu
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: Virology

description: Additional file 2: Supplement Table 2. The incidences of thromboembolism and bleeding events in patients prescribed warfarin or NOAC during follow-up.