cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comparative analysis of biodesulfurization of dibenzothiophene (DBT) and 4,6-dimethyl dibenzothiophene (4,6-DMDBT) by 4S pathway using molecular simulations
Creators: name: Das, Pushpita
name: Umesh
name: Barbora, Lepakshi
name: Moholkar, Vijayanand Suryakant
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: In this paper, we have analyzed biodesulfurization of dibenzothiophene (DBT) and 4,6-dibenzothiophene (4,6-DMDBT) by 4S metabolic pathway using molecular simulations. Docking analysis revealed lower binding energies and inhibition constants (Ki) for 4,6-DMDBT and its metabolic intermediates with DSZ enzymes than DBT and its intermediates. The complexes of substrate and its metabolites with DSZ enzymes had higher stability for 4,6-DMDBT than DBT owing to lower RMSF values than apoprotein. The docking analysis revealed affinity of the inhibitors HBPS and HBP (for DBT) and DMHBPS and DMHBP (for 4,6-DMDBT) toward DSZ enzyme due to negative binding energies. Molecular dynamics simulations showed stability of several enzyme–inhibitor complexes. The inhibitory effect of DMHBPS on DSZC enzyme (Ki = 1.53 µM) and DMHBP on DSZB enzyme (Ki = 3.87 µM) was most marked. The inhibitory effect of HBP on DSZC and DSZB enzymes was moderate due to Ki of 6.36 and 7.93 µM, respectively. The inhibition effect of DMHBP on the DSZA enzyme was insignificant due to high Ki of 53.6 µM. In summary, higher stability of enzyme–substrate complexes and strong inhibition by DMHBPS and DMHBP (due to very low Ki) contribute to slower biodesulfurization of 4,6-DMDBT as compared to DBT.
Development of an attenuated glutamine synthetase (GS) selection system for the stable expression of tissue plasminogen activator in CHO-K1 cells
Creators: name: Raigani, Mozhgan
name: Namdar, Pegah
name: Barkhordari, Farzaneh
name: Seyedjavadi, Sima Sadat
name: Rahimpour, Azam
name: Adeli, Ahmad
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Chinese hamster ovary (CHO) cells represent the most common host system for the expression of high-quality recombinant proteins. The development of stable CHO cell lines used in industrial recombinant protein production often relies on dihydrofolate reductase (DHFR) and glutamine synthetase (GS) amplification systems. Conventional approaches to develop stable cell lines lead to heterogeneous cell populations. Consequently, it is desirable to adopt innovative strategies to increase the efficiency of clone selection to reduce the time and effort invested in the cell line development process. Attenuating the selection marker gene is an effective strategy for isolating high-producing cells. In this study, we evaluated the efficiency of an attenuated glutamine synthetase selection system for the expression of human tissue plasminogen activator (t-PA) in CHO cells. We introduced an AU-rich element (ARE) at the 3’UTR of the glutamine synthetase coding sequence and employed a weak promoter (mSV40) for the expression of this gene. Subsequently, we analyzed the effect of ARE on the GS RNA levels, and recombinant t-PA expression. Our results demonstrate that the use of ARE significantly enhances the detection of high expressing cells compared to the control. Additionally, the t-PA expression level in GS-ARE clones was approximately 900-fold greater than those without the ARE.
تمثلات المُدرسين المغاربة حول مكانة الموارد الجمالية في درس الفلسفة؛ بحث ميداني في سوسيولوجيا التربية
Creators: name: الأندلوسي, حمزة
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Education
subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: ينتمي هذا البحث الميداني إلى حقل سوسيولوجيا التربية، ونَرُومُ من خلاله تقييم مدى حضور الموارد الجمالية والفنية في مُمَارَسَات مُدَرِّسِي مادة الفلسفة في الثانوي التأهيلي بالمغرب، وذلك من أجل النظر فيما إذا كانت الأطر النظرية والمرجعية في مادة الفلسفة قابلة للتطبيق في الفصول التعليمية أم لا؛ إذ تَنُصُّ هذه الأطر النظرية الماثلة في كُتَيِّب توجيهات المادة على أهمية استدعاء الموارد الجمالية والفنية كدعامات بيداغوجية في عملية التدريس. لقد اعتمدنا لأجل هذا الغرض على منهجية كَمِّيَة تَقُومُ على الاستمارة كأداة لمساءلة الأساتذة المبحوثين، وعلى التحليل الإحصائي كأداة لبناء الاستنتاجات والتوصل إلى خلاصات علمية رصينة؛ أما من جهة النتائج، فقد انتهى بحثنا إلى محدودية حضور الموارد الجمالية والفنية في الممارسات الفصلية لأساتذة مادة الفلسفة، ومَرَدُّ ذلك راجع إلى عوائق لوجِستيكية كغياب السبورة الالكترونية الذكية أو غياب العارض الضوئي مثلا، وإلى تمثلات سلبية عند شرائح عريضة من الأساتذة تُجاه الفنون والجماليات، إذ يَعتبر كثير من المبحوثين أن الموارد الفرجوية-الحسية تنزل بمستوى الدرس الفلسفي إلى مرتبة الابتذال والسطحية والشعبوية.
Ultrasound-assisted extraction of Stachys chasmosericea: phytochemical profile, antioxidant potentials via RACI analysis, and enzyme inhibitory activities
Creators: name: Solmaz, Fatma Ozlem Kargin
name: Isitez, Nilay
name: Sarikurkcu, Cengiz
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Understanding the bioactive potential of plant extracts requires detailed evaluations of their chemical composition and bioactivities. This study investigated the chemical profiles, antioxidant properties, and enzyme inhibitory activities of water and methanol extracts of Stachys chasmosericea Ayasligil & P.H.Davis obtained via ultrasound-assisted extraction. The methanol extract displayed significantly higher total phenolic and flavonoid contents compared to the water extract. Chromatographic analysis revealed verbascoside and chlorogenic acid as the dominant compounds in the methanol extract, whereas the water extract contained higher levels of polar compounds like p-coumaric acid. Antioxidant assays demonstrated the methanol extract’s superior activity. Conversely, the water extract excelled in metal chelation. RACI values confirmed the methanol extract’s overall antioxidant superiority (RACI = 0.65) over the water extract (RACI = −0.65). Enzyme inhibition assays revealed the methanol extract’s stronger activity against AChE, BChE, α-amylase, α-glucosidase, and tyrosinase whereas the water extract showed weaker inhibition. Both extracts demonstrated potential for managing oxidative stress and enzyme-related disorders but require further in vivo validation. This study highlights S. chasmosericea, particularly its methanol extract, as a promising source of natural antioxidants and enzyme inhibitors. Future research should focus on isolating individual bioactives and exploring their mechanisms of action in biological systems.
Table_S2_R1 – Supplemental material for People With Parkinson’s Disease Exhibit Reduced Cognitive and Motor Cortical Activity When Undertaking Complex Stepping Tasks Requiring Inhibitory Control
Creators: name: Pelicioni, Paulo H. S.
name: R., Stephen
name: Okubo, Yoshiro
name: Sturnieks, Daina L.
name: Menant, Jasmine C.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, Table_S2_R1 for People With Parkinson’s Disease Exhibit Reduced Cognitive and Motor Cortical Activity When Undertaking Complex Stepping Tasks Requiring Inhibitory Control by Paulo H. S. Pelicioni, Stephen R. Lord, Yoshiro Okubo, Daina L. Sturnieks and Jasmine C. Menant in Neurorehabilitation and Neural Repair
Representations of Moroccan Teachers about the Value of Aesthetic Resources in Philosophy Lessons; a Field Reasearch in the Sociology of Education
Creators: name: Andaloussi, Hamza
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Education
subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: This scientific paper belongs to the field of sociology of education, and through it we aim to evaluate the presence of aesthetic and artistic resources in the practices of teachers of philosophy in the qualifying secondary school in Morocco, in order to consider whether the theoretical and reference frameworks in the subject of philosophy are applicable in educational classrooms or not. These theoretical frameworks present in the Ministerial Directive Book for Philosophy indicates the importance of invoking aesthetic resources as pedagogical supports in the teaching process. For this purpose, we have We have adopted a quantitative methodology based on the questionnaire as a tool for questioning the Teachers, those who are the subject of research, and on statistical analysis as a tool for building conclusions. As for the results, Our research concludes that the presence of aesthetic and artistic resources is limited In the classrooms of philosophy teachers, and this is due to logistical obstacles such as the absence of the Interactive whiteboard or the absence of the projector,… and to negative representations of large segments of teachers towards arts and aesthetics, as Many respondents consider that aesthetic resources cause philosophy lessons to be trite, not serious and shallow.
MSX817577_supp_mat – Supplemental material for Video feedback and the choice of strategies of college-level guitarists during individual practice
Creators: name: Boucher, Mathieu
name: Creech, Andrea
name: Dubé, Francis
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, MSX817577_supp_mat for Video feedback and the choice of strategies of college-level guitarists during individual practice by Mathieu Boucher, Andrea Creech and Francis Dubé in Musicae Scientiae
sj-pdf-1-jla-10.1177_2472630320969147 – Supplemental material for Metabolomic Signatures in Pediatric Crohn’s Disease Patients with Mild or Quiescent Disease Treated with Partial Enteral Nutrition: A Feasibility Study
Creators: name: Marques, Jair Gonzalez
name: Engy Shokry
name: Frivolt, Klara
name: Werkstetter, Katharina Julia
name: Annecarin Brückner
name: Schwerd, Tobias
name: Koletzko, Sibylle
name: Koletzko, Berthold
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-jla-10.1177_2472630320969147 for Metabolomic Signatures in Pediatric Crohn’s Disease Patients with Mild or Quiescent Disease Treated with Partial Enteral Nutrition: A Feasibility Study by Jair Gonzalez Marques, Engy Shokry, Klara Frivolt, Katharina Julia Werkstetter, Annecarin Brückner, Tobias Schwerd, Sibylle Koletzko and Berthold Koletzko in SLAS Technology
ई रुपी आणि अर्थकारण
Creators: name: Rakshit Madan Bagde, Dr.
Publisher: name: Tumbe Group of International Journals
Year: 2022

description: भारताचे माननीय पंतप्रधान श्री नरेंद्र मोदी यांनी वेळोवेळी डिजिटल उपक्रम सुरू केले आहेत. गेल्या काही वर्षांत भारतात एक प्रकारची डिजिटल क्रांती झालेली आपणास दिसून येते आहे. भारतीय नागरिक डिजिटल पेमेंट पद्धतींबद्दल अधिक जागरूक झाले आहेत ज्यामुळे जीवनमानात सुधारणा होत आहे. आर्थिक वर्ष 2023 मध्ये भारत डिजिटल चलन जारी करण्यास सुरुवात करेल, असे अर्थमंत्री निर्मला सीतारामन यांनी अर्थसंकल्पात घोषणा केली होती. 2 ऑगस्ट 2021 रोजी, भारताचे पंतप्रधान श्री नरेंद्र मोदी e-RUPI डिजिटल प्लॅटफॉर्म नावाचे डिजिटल पेमेंट प्लॅटफॉर्म लॉन्च केले आहे. नॅशनल पेमेंट्स कॉर्पोरेशन ऑफ इंडिया (NPCI) ने डिपार्टमेंट ऑफ फायनान्शियल सर्व्हिसेस (DFS), नॅशनल हेल्थ ऑथॉरिटी (NHA), आरोग्य आणि कुटुंब कल्याण मंत्रालय (MoHFW) आणि भागीदार बँकांच्या सहकार्याने हे अभिनव डिजिटल सोल्यूशन लॉन्च केले आहे ज्याला 'ई- RUPI' असे नाव देण्यात आले आहे. या पेपर च्या माध्यमातून ई रुपया काय आहे, त्याची कार्ये आणि भारतीय अर्थव्यवस्थेवरील त्याचा होणारा परिणाम अभ्यासण्यात येणार आहे.
Improved doramectin production based on high-throughput screening and medium optimization in Streptomyces avermitilis
Creators: name: Wang, Yu
name: He, Huan
name: Li, Siqi
name: Ren, Limei
name: Li, Xiaobing
name: Wang, Xiaoru
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Doramectin, a 16-membered macrocyclic lactone that is widely used in the treatment of mammalian parasitic diseases. Doramectin was produced by mutant Streptomyces avermitilis using cyclohexanecarboxylic acid as a precursor. As a semi-synthetic insecticidal agent produced, the production of doramectin was low, which could not be satisfy the demands of industrial fermentation. In this study, a high-yield mutant strain S. avermitilis DA-137 was screened from the starting strain S. avermitilis D-11 through a high-throughput screening strategy. S. avermitilis D-11 was treated with iterative atmospheric and room temperature plasma mutagenesis to induce mutations. Mutation strains were prescreened by spreading on enhanced doramectin-tolerance plates and were rescreened in 24-deep microtiter plates and via microplate readers to obtain high-producing strains. The resulting mutant strain S. avermitilis DA-137 produced 431.5 mg/L doramectin, a 187% increase compared to that of D-11, revealing mutagenesis and doramectin-tolerance screening is an efficient method to enhance doramectin production. Then, fermentation medium was optimized using the response surface method to improve doramectin production. In the optimized fermentation medium, the yield of doramectin was increased to 934.5 mg/L in shake flask. Furthermore, batch culture was carried out in a 50 L fermenter, and the yields of doramectin reached 1217 mg/L at 216 h, which was the highest yield reported to date. This study demonstrates a successful approach for enhancing doramectin production through high-throughput screening strategy and medium optimization, serving as a reference for increasing the yield of other macrocyclic lactone antibiotics.
ई रुपी आणि अर्थकारण
Creators: name: Rakshit Madan Bagde, Dr.
Publisher: name: Humanities Commons
Year: 2022

description: भारताचे माननीय पंतप्रधान श्री नरेंद्र मोदी यांनी वेळोवेळी डिजिटल उपक्रम सुरू केले आहेत. गेल्या काही वर्षांत भारतात एक प्रकारची डिजिटल क्रांती झालेली आपणास दिसून येते आहे. भारतीय नागरिक डिजिटल पेमेंट पद्धतींबद्दल अधिक जागरूक झाले आहेत ज्यामुळे जीवनमानात सुधारणा होत आहे. आर्थिक वर्ष 2023 मध्ये भारत डिजिटल चलन जारी करण्यास सुरुवात करेल, असे अर्थमंत्री निर्मला सीतारामन यांनी अर्थसंकल्पात घोषणा केली होती. 2 ऑगस्ट 2021 रोजी, भारताचे पंतप्रधान श्री नरेंद्र मोदी e-RUPI डिजिटल प्लॅटफॉर्म नावाचे डिजिटल पेमेंट प्लॅटफॉर्म लॉन्च केले आहे. नॅशनल पेमेंट्स कॉर्पोरेशन ऑफ इंडिया (NPCI) ने डिपार्टमेंट ऑफ फायनान्शियल सर्व्हिसेस (DFS), नॅशनल हेल्थ ऑथॉरिटी (NHA), आरोग्य आणि कुटुंब कल्याण मंत्रालय (MoHFW) आणि भागीदार बँकांच्या सहकार्याने हे अभिनव डिजिटल सोल्यूशन लॉन्च केले आहे ज्याला  'ई- RUPI' असे नाव देण्यात आले आहे. या पेपर च्या माध्यमातून ई रुपया काय आहे, त्याची कार्ये आणि भारतीय अर्थव्यवस्थेवरील त्याचा होणारा परिणाम अभ्यासण्यात येणार आहे.
Slides: Epidemiology in the Bhelasaṃhitā: The Chapter on Distinctions According to Land and People
Creators: name: Angermeier, Vitus
Publisher: name: unknown
Year: 2022
Subjects: subject: Malaria
subject: Epidemics
subject: Manuscripts, Sanskrit
subject: Plague
subject: Medicine, Ayurvedic
subject: Fever
subject: Epidemiology
subject: Sanskrit literature
subject: Communicable diseases
subject: Veterinary medicine

description: Presentation in the working group "History of Science in Early South Asia" at https://www.chstm.org/early-south-asia on Dec. 19th 2022.
Slides: Epidemiology in the Bhelasaṃhitā: The Chapter on Distinctions According to Land and People
Creators: name: Angermeier, Vitus
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Medicine, Ayurvedic
subject: Sanskrit literature
subject: Manuscripts, Sanskrit
subject: Epidemics
subject: Epidemiology
subject: Fever
subject: Malaria
subject: Plague
subject: Veterinary medicine
subject: Communicable diseases

description: Presentation in the working group "History of Science in Early South Asia" at https://www.chstm.org/early-south-asia on Dec. 19th 2022.
Molecular dynamics simulation and validation of spiramycin extraction using the thermosensitive polymer NPE-108/water aqueous two-phase system
Creators: name: Zheng, Xiaotong
name: Zheng, Ting
name: Wang, Wen
name: Cao, Xuejun
name: Wan, Junfen
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Spiramycin is a 16-membered macrolide antibiotic widely used in the medical field. Industrial extraction of antibiotics from fermentation broth using organic solvents raises various environmental and health concerns. In this study, a thermosensitive polymer, NPE-108, was used to construct an aqueous two-phase system (ATPS) for the extraction of spiramycin. We used Gromacs software to develop a molecular dynamics simulation model to reveal the distribution mechanism of spiramycin molecules in the NPE-108/water ATPS from a microscopic perspective. Additionally, we examined the effects of volume ratio, temperature, and pH on extraction through experimentation. Under the optimal conditions for forward extraction, the distribution coefficient and extraction efficiency were 25.3 and 89.9%, respectively. Under the optimal conditions for back extraction, the distribution coefficient and extraction efficiency were 6.8 and 81.5%, respectively. Optimization of crystallization conditions resulted in a crystal yield of 88.1% and a purity of 98.4%. The content of both spiramycin components and impurities in the crystalline sample met the requirements of the European Pharmacopeia. The results of this study provided insights into molecular interactions and the extraction process, offering a more environmentally friendly and economically viable alternative for industrial spiramycin production.
Photonics4All - Conduct Photonics For Investment In France And Slovakia
Creators: name: Gerente, Fiona
name: Chorvat, Dusan
Publisher: name: Zenodo
Year: 2017
Subjects: Photonics
Light
B2B
B2C
Investors
entrepreneurs
business angels
start-ups
pitching
matchmaking
innovation support
financing

description: This project deliverable describes the organisation of different Photonics for Investment Events. “Photonics for investments” focuses on the support and investment in innovative ideas and photonics applications. The objective of this project task is to provide the opportunity for Photonics SMEs to present their products or services during pitch presentations to new customers and investors.

The Photonics for Investment events have three main objectives. The first objective is to connect entrepreneurs looking for funds with private investors seeking to invest their money. The second objective is to inform and educate private investors, not only on commercial and financial opportunities related to photonic technologies, but also about their specificities (degree of disruptiveness, R&D maturation, generic technologies, capital intensive, low scalability etc.). The third objective is to enable entrepreneurs to gain experience on the art of the pitch, which is becoming more and more useful for them. The Photonics for Investment events took place in Slovakia and France.
Real-world effectiveness of mepolizumab in asthma: a systematic review and meta-analysis
Creators: name: Di Bona, Danilo
name: Paoletti, Giovanni
name: Carlucci, Palma
name: Spataro, Federico
name: Weng, Stephen
name: Howarth, Peter
name: Canonica, Giorgio W.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Exacerbations and suboptimal disease control are common in severe asthma with an eosinophilic phenotype (SAep). Mepolizumab, an anti-interleukin-5 monoclonal antibody, has demonstrated efficacy and safety in randomized controlled trials (RCTs). We aimed to strengthen the real-world evidence base for mepolizumab in SAep. We analyzed data from Italian participants of REALITI-A, a global, real-world, prospective, observational study (primary outcome: rate of clinically significant exacerbations [CSEs]). Using these data and those from Italian real-world studies of mepolizumab (identified by systematic literature review), we performed a meta-analysis. In the Italian cohort of REALITI-A (n = 244), mean CSE rate was lower 12 months post-mepolizumab initiation versus 12 months pre-mepolizumab (0.67 vs. 3.74 CSEs/patient/year; relative risk [RR], 0.18; 95% confidence interval (CI), 0.15–0.22; p < .001). The meta-analysis included 863 patients. Mean CSE rate decreased from 4.2/patient/year at baseline to 0.71/patient/year post-mepolizumab initiation. Mean oral corticosteroid (OCS) dose reduced by 8.66 mg/day (95% CI, 6.17–11.16 mg/day; p < .0001) from baseline (10.0 mg/day). The RR for OCS maintenance, post- versus pre-mepolizumab, was 0.37 (95% CI, 0.27–0.52; p < .0001). A mean increase in Asthma Control Test score of 6.50 (95% CI, 5.67–7.33; p < .00001) was observed. Proportions of patients reporting adverse events were low. Real-world experience in this unified health care system identifies that mepolizumab has a low adverse event rate and provides consistent clinical benefits. Mepolizumab represents an important treatment option for patients with SAep.
lesser saints, on 23 January in the Martyrologium Hieronymianum: in Mauritania, Rome, Ancyra (Galatia)
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: All evidence related to lesser saints, on 23 January in the Martyrologium Hieronymianum: in Mauritania, Rome, Ancyra (Galatia).
A decision tree analysis to evaluate the optimal approach to screen allergic bronchopulmonary aspergillosis in asthmatic patients
Creators: name: Agarwal, Ritesh
name: Sehgal, Inderpaul Singh
name: Saxena, Puneet
name: Dhooria, Sahajal
name: Muthu, Valliappan
name: Soundappan, Kathirvel
name: Prasad, Kuruswamy Thurai
name: Garg, Mandeep
name: Rudramurthy, Shivaprakash Mandya
name: Aggarwal, Ashutosh Nath
name: Chakrabarti, Arunaloke
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Various methods are available to screen for allergic bronchopulmonary aspergillosis (ABPA) in asthma, but their comparative performance remains uncertain. To identify the optimal screening algorithm for ABPA in asthmatic patients and evaluate the crude cost of various diagnostic approaches. We performed a post hoc analysis of prospectively collected data from consecutive adult asthmatic patients evaluated for ABPA. The diagnosis was based on the revised International Society for Human and Animal Mycology ABPA Working Group criteria. Initial evaluations included measurements of serum Aspergillus fumigatus-IgE (≥0.35 kUA/L), serum total IgE (≥500 IU/mL), serum A. fumigatus-IgG (≥27 mgA/L), blood eosinophil count (BEC ≥500 cells/μL), and chest CT findings. A decision tree was manually constructed using recursive partitioning to identify the most effective diagnostic pathway. Among 543 adult asthmatics, 106 were diagnosed with ABPA. Serum A. fumigatus-IgE was positive in 221 (40.7%) patients, while serum total IgE was elevated (≥500 IU/mL) in 300 (55.3%) patients. The serum total IgE-based approach required 196 additional tests during screening, compared to 115 in the A. fumigatus-IgE method. The BEC-based strategy missed 28 cases of ABPA. Although the CT-directed protocol had the fewest false positives, it required 437 additional screening radiographic procedures and missed eight ABPA cases. The A. fumigatus-IgE pathway emerged as the most cost-effective, whereas imaging-based strategies were the most expensive. Serum A. fumigatus-IgE is the optimal screening test for ABPA in asthma. It minimizes unnecessary testing while maintaining high diagnostic accuracy, making it a preferable approach in clinical practice.
ASTHMAXcel perception: a mobile health application for training in the perception of airflow limitation
Creators: name: Wysocki, Matthew
name: Rodriguez, Juliana
name: Simpson, Talia
name: Malam, Bassit
name: Maewsky, Nicole
name: Bidiwala, Aneela
name: Mowrey, Wenzhu
name: Jariwala, Sunit
name: Reznik, Marina
name: Feldman, Jonathan M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: ASTHMAXcel Perception is an expansion of prior ASTHMAXcel mobile health applications for children with asthma. ASTHMAXcel Perception was evaluated for its ability to improve asthma control and perception of airflow limitation. Patients with asthma ages 15–21 were randomized to receive ASTHMAXcel Perception with peak expiratory flow (PEF) feedback or usual care (UC). A baseline visit was followed by 3 intervention sessions across 6 wk in the intervention group. Assessments in both groups were designed to occur at baseline, 6-week (primary time point), and 3-month follow-up. Self-reported asthma control (primary outcome), asthma quality of life, asthma knowledge, medication adherence, healthcare utilization, app usage, and perception of airflow limitation (measured by comparing self-reported PEF guess to actual PEF) were assessed. 45 patients were enrolled (PEF n = 22, UC n = 23). At 6 wk, the PEF group reported better asthma control than the UC group (18.7 vs 16.7, p < .05). In the PEF group, accurate perception increased from baseline to 6 wk (48% vs 77%, p = 0.01) and from baseline to 3 months (48% vs 74%, p = 0.009). Over-perception decreased from baseline to 6 wk (26% vs 5%, p = 0.041). The number of logins was associated with greater accuracy in perception of airflow limitation from baseline to 2 wk (r = 0.91, p = 0.002) and 2 wk to 4 wk (r = 0.77, p < .05). No significant differences were found in asthma quality of life, asthma knowledge, medication adherence, or healthcare utilization between the two groups. ASTHMAXcel Perception improved asthma control and was associated with greater accuracy in perception of airflow limitation.
Patient experience, understanding and self-management of asthma attacks: a qualitative study
Creators: name: Pradhan, Ashish
name: Jayes, Leah
name: Bains, Manpreet
name: Martin, Matthew J.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Asthma attacks (AA) are potentially life-threatening complications of asthma associated with high levels of morbidity, mortality and rising healthcare costs. Patient experience, impact and understanding of AA is poorly described in the literature. Enhanced understanding will identify unmet needs in asthma care and support the development of improved personalized strategies for managing and preventing attacks. To explore patients’ experiences and understanding of AAs, the impact of AAs on their lives and self-management strategies during attacks. Single center (UK) qualitative semi-structured interview study with 30 patients who recently had asthma attacks (≤4 wk). Data were analyzed using the framework approach. The patient experience and impact of AA varied, including recognizing an impending attack. Variation in patients’ self-management behaviors during AAs was observed and was influenced by prior experience of attacks and care received for these and other life priorities. Several behaviors previously recognized as contributory to asthma deaths, including short-acting β-agonist (SABA) overuse, poor recognition of the risk of adverse outcomes, and delay in seeking medical help were identified and reported. Most patients had a poor understanding of AAs and their management. This study describes the differing impact of AA on patient experiences and understanding of asthma attacks. These differences, combined with healthcare factors and attack characteristics, affect patient self-management approaches. These findings highlight unmet needs in asthma attack care. ClinicalTrials.gov ID NCT04410120
Between universal values and national ties: Western European freemasonries face the challenge of ‘Europe’, 1850–1930
Creators: name: Berger, Joachim
Publisher: name: Humanities Commons
Year: 2011
Subjects: subject: Internationalism
subject: Internationalism--Societies, etc.
subject: Fraternal organizations
subject: Freemasonry
subject: Europe
subject: Civil society
subject: Peace movements

description: How did (Western) European freemasonries on a transnational level came to terms with the idea of a closer union of the European peoples? Concepts of “Europe” and “Europeanness” were the background music of the formation of masonic pan-European networks, building on transnational encounters either by individual freemasons (in the Universala Framasona Ligo or at the international masonic manifestations for peace) or by Grand Lodge representatives (e.g. in the Association maçonnique internationale). Generally, masonic discourse on a transnational level was characterized by a tension between geographically and politically confined ideas of “Europe” on the one hand and the general ideal of humanitarianism and universal brotherhood on the other.  The generally prevailing 'European' sense of superiority until the late 19th century, on the one hand, and the sense of threat and insecurity that grew stronger in the decade before the world war, on the other, overlapped also within Freemasonry. With the First World War, diagnoses of crisis became predominant. These negative scenarios focusing on "Europe" were an alternative mode of expression for Freemasonry that went beyond its positive image of humanity, which assumed the perfectibility of humankind. Speaking about Europe as a spatially conceived entity made it possible to articulate feelings of threat that the universalistic-optimistic talk of a "world brotherhood" had to avoid.
Real-world effectiveness of mepolizumab in asthma: a systematic review and meta-analysis
Creators: name: DiBona, Danilo
name: Paoletti, Giovanni
name: Carlucci, Palma
name: Spataro, Federico
name: Weng, Stephen
name: Howarth, Peter
name: Canonica, Giorgio W.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Objective Exacerbations and suboptimal disease control are common in severe asthma with an eosinophilic phenotype (SAep). Mepolizumab, an anti-interleukin-5 monoclonal antibody, has demonstrated efficacy and safety in randomized controlled trials (RCTs). We aimed to strengthen the real-world evidence base for mepolizumab in SAep. Methods We analyzed data from Italian participants of REALITI-A, a global, real-world, prospective, observational study (primary outcome: rate of clinically significant exacerbations [CSEs]). Using these data and those from Italian real-world studies of mepolizumab (identified by systematic literature review), we performed a meta-analysis. Results In the Italian cohort of REALITI-A (n = 244), mean CSE rate was lower 12 months post-mepolizumab initiation versus 12 months pre-mepolizumab (0.67 vs 3.74 CSEs/patient/year; relative risk [RR], 0.18; 95% confidence interval (CI), 0.15–0.22; P < .001). The meta-analysis included 863 patients. Mean CSE rate decreased from 4.2/patient/year at baseline to 0.71/patient/year post-mepolizumab initiation. Mean oral corticosteroid (OCS) dose reduced by 8.66 mg/day (95% CI, 6.17–11.16 mg/day; P < .0001) from baseline (10.0 mg/day). The RR for OCS maintenance, post- versus pre-mepolizumab, was 0.37 (95% CI, 0.27–0.52; P < .0001). A mean increase in Asthma Control Test score of 6.50 (95% CI, 5.67–7.33; P < .00001) was observed. Proportions of patients reporting adverse events were low. Conclusions Real-world experience in this unified health care system identifies that mepolizumab has a low adverse event rate and provides consistent clinical benefits. Mepolizumab represents an important treatment option for patients with SAep.
ASTHMAXcel Perception: A mobile health application for training in the perception of airflow limitation
Creators: name: Wysocki, Matthew
name: Rodriguez, Juliana
name: Simpson, Talia
name: Malam, Bassit
name: Maewsky, Nicole
name: Bidiwala, Aneela
name: Mowrey, Wenzhu
name: Jariwala, Sunit
name: Reznik, Marina
name: Feldman, Jonathan M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: ASTHMAXcel Perception is an expansion of prior ASTHMAXcel mobile health applications for children with asthma. ASTHMAXcel Perception was evaluated for its ability to improve asthma control and perception of airflow limitation. Patients with asthma ages 15-21 were randomized to receive ASTHMAXcel Perception with peak expiratory flow (PEF) feedback or usual care (UC). A baseline visit was followed by 3 intervention sessions across 6 weeks in the intervention group. Assessments in both groups were designed to occur at baseline, 6-week (primary time point), and 3-month follow-up. Self-reported asthma control (primary outcome), asthma quality of life, asthma knowledge, medication adherence, healthcare utilization, app usage, and perception of airflow limitation (measured by comparing self-reported PEF guess to actual PEF) were assessed. 45 patients were enrolled (PEF n = 22, UC n = 23). At 6 weeks, the PEF group reported better asthma control than the UC group (18.7 vs 16.7, p < .05). In the PEF group, accurate perception increased from baseline to 6-weeks (48% vs 77%, p = 0.01) and from baseline to 3-months (48% vs 74%, p = 0.009). Over-perception decreased from baseline to 6-weeks (26% vs 5%, p = 0.041). The number of logins was associated with greater accuracy in perception of airflow limitation from baseline to 2-weeks (r = 0.91, p = 0.002) and 2-weeks to 4-weeks (r = 0.77, p < .05). No significant differences were found in asthma quality of life, asthma knowledge, medication adherence, or healthcare utilization between the two groups. ASTHMAXcel Perception improved asthma control and was associated with greater accuracy in perception of airflow limitation.
Additional file 2 of Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress
Creators: name: Wang, Ruijie
name: Zhang, Meng
name: Wang, Hui
name: Chen, Liangliang
name: Zhang, Xuexian
name: Guo, Liping
name: Qi, Tingxiang
name: Tang, Huini
name: Shahzad, Kashif
name: Wang, Hailin
name: Qiao, Xiuqin
name: Wu, Jianyong
name: Xing, Chaozhu
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Fig. S1. Experimental validation of the other six cotton circRNAs via PCR amplification and Sanger sequencing. (A) Intergenic circRNA94. (B) Intergenic circRNA177. (C) Intergenic circRNA265. (D) Intergenic circRNA484. (E) Intergenic circRNA86. (F) Exonic circRNA26.
Uncovering the spectrum of healthcare resource utilization and costs across moderate to severe asthma: high-cost subgroups and impact of biologics
Creators: name: Hwee, Jeremiah
name: Fu, Qinggong
name: Benson, Victoria S.
name: Kwiatek, Justin
name: Alfonso-Cristancho, Rafael
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: The healthcare burden of moderate asthma is not as well studied as severe asthma. This study used 2019 US claims data to characterize patients in Global Initiative for Asthma (GINA) steps 3 to 5 (moderate to severe) during the first 90 days of 2019. Patient characteristics, healthcare resource utilization and costs were described for all patients and GINA groups. Patients in GINA 3 accounting for the top 10% and 20% of asthma-related total costs were also analyzed. In the overall asthma population (N = 337 015), mean asthma-related healthcare cost per patient was $12 560; for GINA 3, 4 and 5, costs were $10 265, $12 923, and $22 601, respectively. For the GINA 3 top 10% and 20% cost subgroups, these expenditures were higher than for GINA 5 ($54 549 and $94 386, respectively), driven by outpatient and inpatient costs. The high-cost GINA 3 subgroups were older, more often female and had a higher comorbidity burden versus GINA 4 or 5. An exploratory analysis suggested that biologic initiation significantly increased costs in patients initially in GINA 3 (p < 0.0001), but significantly reduced costs in GINA 3 top 10% and 20% cost subgroups (both p < 0.01). Results indicate patients receiving GINA 3 treatment can have a high disease burden and may benefit from treatment with a biologic.
Regimes of territoriality. Overseas conflicts and inner-European relations, c. 1870–1930
Creators: name: Berger, Joachim
Publisher: name: Humanities Commons
Year: 2015
Subjects: subject: Internationalism
subject: Imperialism
subject: Human territoriality
subject: Freemasonry
subject: South Africa--Transvaal
subject: Internationalism--Societies, etc.

description: This essay focuses on territorial conflicts between European masonic bodies outside Europe, and on the impact of these conflicts on inner-European masonic relations. The period between c. 1870 and c. 1930 marks the height of the European expansion respectively the age of ‘high imperialism’. It also marks the first wave of decolonization. The tides of international masonic relations mirror these overall developments. Bilateral territorial conflicts had a major impact on masonic internationalism around 1900 and in the interwar period. Geopolitical rivalry both deepened and blurred the demarcations between the various ideological ‘camps’ of (European) freemasonries. The ‘Association maçonnique internationale’ made efforts to implement a ‘Code de Droit Maçonnique international’ and to establish itself as a global tribunal of arbitration. By the end of the period, territorial jurisdiction had become a key issue when it came to defining masonic ‘regularity’.
Assessment of the Enterprise Risk Management (ERM) in the Nigerian Banking Industry
Creators: name: Akaninyene Orok, Dr.
name: Udoka, Chris
Publisher: name: Humanities Commons
Year: 2017
Subjects: subject: Corporate governance
subject: Risk management

description: This study aimed at evaluating enterprise risk management practice by Deposit Money Banks in Nigeria. Evolving from the research were three specific objectives which were reconstructed into research hypotheses. The hypotheses investigated the relationship between objections and challenges faced by Nigerian banks, government policy, risk and acceptance of enterprise risk management by Nigerian banks. The study utilized an Ex-Post Facto design. A sample of 374 respondents extracted across six geopolitical zones in Nigeria responded to a re-validated 5 points Likert Scale questionnaire. Data extracted from the collection was evaluated using ordinary least square OLS regression analysis. The study revealed that various challenges of practicing banks significantly influence the level of acceptance and implementation of ERM in Nigeria, the government policies on ERM has a direct and significant relationship on the practice of ERM by players in the industry and that the practice of ERM has positively influenced the performance of the Nigerian banks that have accepted and implemented ERM. The study recommended that apex institutions should devise a strategic plan and framework to help banks in the implementation of enterprise risk management since it has been adjudged to be the industry best practice in line with Basel III accord.
Association and mechanism of montelukast on sleep disorders: insights from NHANES 2005–2018 data analysis and a network pharmacology study
Creators: name: Zhu, Xingke
name: Lv, Qing
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Studies have suggested associations between montelukast and increased risks of sleep disorders, including overall sleeping problems and insomnia. However, the results of observational studies are not consistent. Understanding these associations is crucial, particularly in patients solely diagnosed with allergic rhinitis, where montelukast use remains prevalent. This study aimed to assess whether montelukast exposure is associated with sleep disorders and elucidate the possible molecular mechanism. We conducted a cross-sectional study of 16,520 adults from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Multivariable regression was used to evaluate the association between montelukast exposure and sleep disorder. Network pharmacology was conducted to identify the mechanisms of montelukast on sleep disorders. Montelukast exposure had a higher prevalence of sleep disorders (25.28%). In a multivariable logistic regression model adjusted for sociodemographic, behavioral, and health characteristics, montelukast exposure was associated with sleep disorders (odds ratio [OR]: 1.72; confidence interval [CI]: 1.32–2.26). Network pharmacology was identified 39 intersection targets and 17 core targets of montelukast on sleep disorders. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested montelukast mainly works through multiple pathways in chemical carcinogenesis-receptor activation, cancer, estrogen signaling pathway, etc. The study implies a potential positive association between long-term montelukast exposure and sleep disorders through multi-faceted mechanisms. It is suggested that attention be given to the possibility of sleep disorders in patients undergoing prolonged montelukast therapy.
Interest Rate Policy and the Growth of the Nigerian Economy (1990-2016)
Creators: name: Akaninyene Orok, Dr.
name: John, John
name: Ndifon, Edim
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Intermediation (Finance)
subject: Economic development

description: This study focused on the effect of interest rate policy on the growth of the Nigerian economy. It sought to assess the significance of interest rate, and to suggest measures that could enhance economic growth in Nigeria. To achieve the objective of the research, some macroeconomic indicators in the Nigerian economy, using an ex-post facto research design were applied. The data were analyzed using the Ordinary Least Square (OLS) method. From the examination, it was uncovered that there was a huge connection between financing cost and GDP in Nigeria. It was additionally found that there was a huge connection between rate for currency exchange and total national output in Nigeria. Inflation was likewise found to significantly affect total national output in Nigeria. In light of these discoveries, it is suggested that the Central Bank of Nigeria (CBN) ought to structure policy framework on the rate of interest that will dependably support and encourage culture of savings in the real sector. This can be accomplished by expanding the rate accruing to savings from foreign and local investors. Additionally, aggregate economic output should be seen as the bane of government policy thrust, through bringing down of rate charged to lending and expanding rate to savings, as this improves financial development.