cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Numerical assessment and experimental verification of the influence of the Hartmann effect in laser beam welding processes by steady magnetic fields
Creators: name: Bachmann, Marcel
name: Avilov, Vjaceslav
name: Gumenyuk, Andrey
name: Rethmeier, Michael
Publisher: name: Technische Universität Berlin
Year: 2015
Subjects: subject: 621 Angewandte Physik
subject: electromagnetic weld pool control
subject: Hartmann effect
subject: laser beam welding
subject: Lorentz force
subject: Marangoni flow
subject: natural convection
subject: aluminium

description: Controlling the dynamics in the weld pool is a highly demanding challenge in deep-penetration laser beam welding with modern high power laser systems in the multi kilowatt range. An approach to insert braking forces in the melt which is successfully used in large-scaled industrial applications like casting is the so-called Hartmann effect due to externally applied magnetic fields. Therefore, this study deals with its adaptation to a laser beam welding process of much smaller geometric and time scale. In this paper, the contactless mitigation of fluid dynamic processes in the melt by steady magnetic fields was investigated by numerical simulation for partial penetration welding of aluminium. Three-dimensional heat transfer, fluid dynamics including phase transition and electromagnetic field partial differential equations were solved based on temperature-dependent material properties up to evaporation temperature for two different penetration depths of the laser beam. The Marangoni convection in the surface region of the weld pool and the natural convection due to the gravitational forces were identified as main driving forces in the weld pool. Furthermore, the latent heat of solid–liquid phase transition was taken into account and the solidification was modelled by the Carman–Kozeny equation for porous medium morphology. The results show that a characteristic change of the flow pattern in the melt can be achieved by the applied steady magnetic fields depending on the ratio of magnetic induced and viscous drag. Consequently, the weld bead geometry was significantly influenced by the developing Lorentz forces. Welding experiments with a 16 kW disc laser with an applied magnetic flux density of around 500 mT support the numerical results by showing a dissipating effect on the weld pool dynamics.
RAQAMLI MARKETING VA IJTIMOIY TARMOQLARNING TURIZMNI RIVOJLANTIRISHDAGI O'RNI
Creators: name: Xodjayeva, M.S.
name: Tursunboyeva, N.Z.
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqola zamonaviy axborot-kommunikatsiya texnologiyalari taraqqiyoti natijasida shakllanayotgan raqamli marketing va ijtimoiy tarmoqlarning turizm sohasi rivojiga ko‘rsatadigan ta’sirini chuqur tahlil qiladi. Turistik xizmatlar targ‘iboti, mijozlar bilan o‘zaro aloqalar va brend imijini shakllantirishda raqamli vositalar muhim omilga aylangan. Tadqiqot davomida SEO (Search Engine Optimization), kontekstli reklama, ijtimoiy tarmoq strategiyalari, influencer marketing va foydalanuvchi yaratuvchi kontent (UGC) kabi vositalarning turizm marketingidagi o‘rni hamda ulardan foydalanishning samaradorligi ko‘rib chiqiladi. O‘zbekiston tajribasi misolida raqamli texnologiyalarni joriy etishdagi amaliy yondashuvlar ham tahlil qilinadi. Maqola natijalari turizm sohasida raqamli yondashuvlardan samarali foydalanish bo‘yicha ilmiy-nazariy va amaliy tavsiyalarni o‘z ichiga oladi.
Investigation of liquid metal embrittlement of dual phase steel joints by electro-thermomechanical spot-welding simulation
Creators: name: Frei, Julian
name: Biegler, Max
name: Rethmeier, Michael
name: Böhne, Christoph
name: Meschut, Gerson
Publisher: name: Technische Universität Berlin
Year: 2019
Subjects: subject: 670 Industrielle Fertigung
subject: RSW
subject: LME
subject: advanced high strength steel
subject: zinc coated steel
subject: testing method
subject: dual phase steel
subject: cracking
subject: electro-thermomechnical model

description: A 3D electro-thermomechanical model is established in order to investigate liquid metal embrittlement. After calibration to a dual phase steel of the 1000 MPa tensile strength class, it is used to analyse the thermo-mechanical system of an experimental procedure to enforce liquid metal embrittlement during resistance spot welding. In this procedure, a tensile stress level is applied to zinc coated advanced high strength steel samples during welding. Thereby, liquid metal embrittlement formation is enforced, depending on the applied stress level and the selected material. The model is suitable to determine and visualise the corresponding underlying stresses and strains responsible for the occurrence of liquid metal embrittlement. Simulated local stresses and strains show good conformity with experimentally observed surface crack locations.
On the Noise Stability and Robustness of Adversarially Trained Networks on NVM Crossbars
Creators: name: Tao, Chun
name: Roy, Deboleena
name: Chakraborty, Indranil
name: Roy, Kaushik
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Applications based on Deep Neural Networks (DNNs) have grown exponentially in the past decade. To match their increasing computational needs, several Non-Volatile Memory (NVM) crossbar based accelerators have been proposed. Recently, researchers have shown that apart from improved energy efficiency and performance, such approximate hardware also possess intrinsic robustness for defense against adversarial attacks. Prior works quantified this intrinsic robustness for vanilla DNNs trained on unperturbed inputs. However, adversarial training of DNNs is the benchmark technique for robustness, and sole reliance on intrinsic robustness of the hardware may not be sufficient. In this work, we explore the design of robust DNNs through the amalgamation of adversarial training and intrinsic robustness of NVM crossbar-based analog hardware. First, we study the noise stability of such networks on unperturbed inputs and observe that internal activations of adversarially trained networks have lower Signal-to-Noise Ratio (SNR), and are sensitive to noise compared to vanilla networks. As a result, they suffer on average 2x performance degradation due to the approximate computations on analog hardware. Noise stability analyses show the instability of adversarially trained DNNs. On the other hand, for adversarial images generated using Square Black Box attacks, ResNet-10/20 adversarially trained on CIFAR-10/100 display a robustness gain of 20-30%. For adversarial images generated using Projected-Gradient-Descent (PGD) White-Box attacks, adversarially trained DNNs present a 5-10% gain in robust accuracy due to underlying NVM crossbar when $ε_{attack}$ is greater than $ε_{train}$. Our results indicate that implementing adversarially trained networks on analog hardware requires careful calibration between hardware non-idealities and $ε_{train}$ for optimum robustness and performance.
description: 13 pages, 14 figures
Sensitivity analysis of the residual stress state in friction stir welding of high strength aluminum alloy
Sensitivitätsanalyse des Eigenspannungszustandes einer rührreibgeschweißten hochfesten Aluminiumlegierung
Creators: name: Bachmann, Marcel
name: Rethmeier, Michael
name: Wu, Chuan Song
Publisher: name: Technische Universität Berlin
Year: 2016
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: friction stir welding
subject: finite element simulation
subject: residual stress
subject: aluminum alloy
subject: COMSOL Multiphysics

description: In this paper, the friction stir welding process was numerically investigated for 6 mm thick aluminum alloy AA2024-T3. The finite element software COMSOL Multiphysics was used to calculate the transient thermal field during welding and the mechanical reaction depending on different mechanical clamping conditions and hardening models subsequently. A thermal pseudo-mechanical (TPM) heat source was implemented. Softening effects of the material due to precipitation hardening dissolution caused by the frictional heat were accounted for. The transient temperature evolution measured by thermocouple elements at various locations was compared to the numerical results. A good agreement was found for the thermal field. A sensitivity study of the mechanical models showed the strong influence of the clamping conditions and the softening model.
description: In diesem Artikel wird der Rührreibschweißprozess für 6 mm dicke Bleche aus AA2024-T3 numerisch untersucht. Die Finite-Elemente-Software COMSOL Multiphysics wurde eingesetzt, um sowohl das transiente Temperaturfeld während des Schweißvorgangs, als auch die entstehenden mechanischen Spannungen für verschiedene Einspannbedingungen und Verfestigungsmodelle zu berechnen. Dabei wurde eine thermo-pseudo-mechanische (TPM) Wärmequelle genutzt. Entfestigungseffekte des Materials, verursacht durch die Reibwärme bedingte Auflösung der Ausscheidungshärtung beim Rührreibschweißen, wurden berücksichtigt. Die transiente Wärmeausbildung wurde mittels Thermoelementen an verschiedenen Positionen gemessen und mit den numerisch ermittelten Werten verglichen. Dabei wurde eine gute Übereinstimmung für das Temperaturfeld erzielt. Eine Sensitivitätsstudie der genutzten mechanischen Modelle zeigt den starken Einfluss der Einspannbedingungen sowie der Entfestigung.
Graphical abstract for publication: Network analyses reveal new insights into the effects of multicomponent Tr14 in an acute inflammation model
Creators: name: Hoch, Matti
name: Biswas, Suchi
Smita
name: Kunzmann, Moritz
name: Cesnulevicius, Konstantin
name: Lescheid, David
name: Schultz, Myron
name: Wolkenhauer, Olaf
name: K. Gupta, Shailendra
Publisher: name: Heel GmbH
Year: 2023
Subjects: classificationCode: 310114
subject: Systems biology
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 321406
subject: Pharmacogenomics
subject: FOS: Medical biotechnology
classificationCode: 3214
subject: Pharmacology and pharmaceutical sciences

description: This is a graphical abstract of a published peer-reviewed article. It was created by the authors of the original article. For a full list of declarations, including funding and author disclosure statements, please read the full open-access article online.
Culex (Culex) andersoni Edwards
Creators: name: Harbach, Ralph E.
name: Wilkerson, Richard C.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Culicidae
Culex
Culex andersoni

description: Culex (Culex) andersoni Edwards
subspecies abyssinicus Edwards, 1941 —original combination: Culex (Culex) andersoni ssp. abyssinicus. Distribution: Ethiopia (Edwards 1941).
subspecies andersoni Edwards, 1914 —original combination: Culex andersoni. Distribution: Comoros, Democratic Republic of the Congo, Eritrea, Kenya, Malawi, Republic of South Africa, Rwanda, Tanzania, Uganda (Wilkerson et al. 2021).
subspecies bwambanus Edwards, 1941 —original combination: Culex (Culex) andersoni ssp. bwambanus. Distribution: Lesotho, Republic of South Africa, Uganda (Wilkerson et al. 2021).
Edwards (1914) described Culex andersoni from specimens collected at Kabete, located outside the borders of Nairobi in the Central Province of Kenya, based principally on features of the male habitus and male genitalia.
Subspecies abyssinicus is only known from Ethiopia, and according to Edwards (1941) the adult is ornamented differently than the typical form but the male genitalia are essentially the same. Because the treatment of the genitalia is rather superficial, it is likely that some differences might be evident upon closer examination. Based on differences in ornamentation and allopatry, abyssinicus is hereby considered a separate species: Culex (Culex) abyssinicus Edwards, 1941. This species should be added to the species of Culex listed in the Encyclopedia of Life.
Subspecies bwambanus and the nominotypical form are both reported from Uganda, and Edward (1941) indicated that they both occur in the Ruwenzori Mountains. However, Edwards described bwambanus from a Ruwenzori location while recognizing the presence of the typical form elsewhere in the same mountains. Although the Ruwenzori Mountains appear to be the only place where the two forms may be in sympatry, Edwards described bwambanus as a new subspecies because of differences in the pale scaling of the hindfemur of the adults, and nearly “hairless” maxillary palpi (“may be rubbed in the type ”), gonocoxite with a more prominent subapical lobe and a narrower gonostylus in the male. Since the available evidence indicates that bwambanus is morphological distinct in the absence of clinal variation, it is hereby afforded species status: Culex (Culex) bwambanus Edwards, 1941. Culex bwambanus is currently listed as a species in the Encyclopedia of Life.
description: Published as part of Harbach, Ralph E. & Wilkerson, Richard C., 2023, The insupportable validity of mosquito subspecies (Diptera: Culicidae) and their exclusion from culicid classification, pp. 1-184 in Zootaxa 5303 (1) on page 82, DOI: 10.11646/zootaxa.5303.1.1, http://zenodo.org/record/8043342
Graphical abstract: Network analyses reveal new insights into the effects of multicomponent Tr14 in an acute inflammation model
Creators: name: Hoch, Matti
name: Biswas, Suchi
Smita
name: Kunzmann, Moritz
name: Cesnulevicius, Konstantin
name: Lescheid, David
name: Schultz, Myron
name: Wolkenhauer, Olaf
name: K. Gupta, Shailendra
Publisher: name: Heel GmbH
Year: 2023
Subjects: classificationCode: 310114
subject: Systems biology
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 321406
subject: Pharmacogenomics
subject: FOS: Medical biotechnology
classificationCode: 3214
subject: Pharmacology and pharmaceutical sciences

description: This is a graphical abstract of a published peer-reviewed article. It was created by the authors of the original article. For a full list of declarations, including funding and author disclosure statements, please read the full open-access article online.
A Methodological Approach to Designing Circular Economy Indicators for Agriculture: An Application to the Egg Sector
Creators: name: Rukundo, Roger
name: Bergeron, Stéphane
name: Bocoum, Ibrahima
name: Pelletier, Nathan
name: Doyon, Maurice
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Analysing production systems from a circular economy (CE) perspective helps to pinpoint interventions to mitigate the environmental footprint by improving resource use efficiency, waste recovery, and prolonged product usage, recycling and reuse. Few studies exist on the measurement of CE at the micro-level. Additionally, available metrics/indicators address only certain aspects of the CE’s socio-economic metabolism, ignoring important components of the CE concept. Other frameworks propose a single indicator that aggregates and summarizes several facets of CE. This study develops a holistic approach for designing indicators with a structured methodology and an analytical framework to assess CE at the micro (unit of production) level in agriculture. The proposed approach is based on the ECOGRAI method for indicator development, and on validation of the methods with experts and final users via an application to egg production in Canada. Twenty-five performance indicators (PI) were generated for 11 decision variables that were selected as important for the sector. This resulted in a practical tool that proposes fourteen actions to improve the economic circularity (EC) of egg farms. Our methodological approach could be replicated to assess CE performance in other agricultural sectors.
The targum (1923:Jan. 9 - 1923:Jan. 16)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1923

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
title: A mechanism underlying improved dual-task performance after practice: Reviewing evidence for the memory hypothesis
Creators: name: Schubert, Torsten
name: Kübler, Sebastian
name: Strobach, Tilo
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: Dual tasks
subject: Dual-task performance
subject: Dual-task practice
subject: Task coordination
subject: Coordination skills
subject: 150 Psychologie
subject: 610 Medizin und Gesundheit

description: Extensive practice can significantly reduce dual-task costs (i.e., impaired performance under dual-task conditions compared with single-task conditions) and, thus, improve dual-task performance. Among others, these practice effects are attributed to an optimization of executive function skills that are necessary for coordinating tasks that overlap in time. In detail, this optimization of dual-task coordination skills is associated with the efficient instantiation of component task information in working memory at the onset of a dual-task trial. In the present paper, we review empirical findings on three critical predictions of this memory hypothesis. These predictions concern (1) the preconditions for the acquisition and transfer of coordination skills due to practice, (2) the role of task complexity and difficulty, and (3) the impact of age-related decline in working memory capacity on dual-task optimization.
Optimization of the manufacturing process of a pediatric omeprazole enteric pellets suspension: Full Factorial Design
Creators: name: Rouaz-El-Hajoui, Khadija
name: Pérez-Lozano, Pilar
name: Fraschi-Nieto, Àlex
name: Mula-Roldán, Xavier
name: Suñé-Pou, Marc
name: Chiclana-Rodríguez, Blanca
name: Suñé-Negre, Josep María
name: García-Montoya, Encarnación
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: The purpose of the present study was to apply the design of experiments (DoE) to develop an omeprazole enteric pellets suspension for use in the pediatric population. This experimental study employed a Full Factorial Design for drug development, encompassing three factors (Aerosil® R972, cetostearyl alcohol, and Span 80) at two levels (2% and 6% for factor A (Aerosil® R972) and 2% and 4% for factors B and C (cetostearyl alcohol and Span 80, respectively)). Following the statistical optimization, the suspension F10 was formulated and subjected to a stability study for one month. The dissolution test results were suboptimal, achieving only an 22% release. Subsequently, eight additional suspensions were devised using hydrophilic oily vehicles (Labraphac Hydrophile WL 1219, Labrafil M2125 CS, and Labrafil M 1944 CS) and excipients (Gelucire 44/14 and Aerosil® 200) to enhance the dissolution profile. Suspension F17 showed over 75% within 30 min, displaying superior sedimentation time when compared to all other formulations, along with effortless resuspension. The findings suggest that the optimal vehicle for the administration of omeprazole enteric pellets in suspension is the formulation comprising Labrafil M 1944 CS, Span 80, and Aerosil® 200. This study has paved the way for an oily suspension vehicle, opening new avenues of research for developing pediatric omeprazole formulations that fulfill gastro-resistance requirements.
Hoiho tracking: 23 July - 20 August 2020
Creators: name: Mattern, Thomas
Publisher: name: figshare
Year: 2020
Subjects: subject: 60207 Population Ecology
subject: FOS: Biological sciences
subject: 60201 Behavioural Ecology
subject: Ecology
subject: 60205 Marine and Estuarine Ecology (incl. Marine Ichthyology)
subject: Marine Biology

description: Starting on 24 August 2020, several attempts were made to recover the last GPS dive logger deployed on a male hoiho from Haywards Point nine days earlier. Until 30 August a total 42 observer hours were invested to recapture the penguin. Numbers of penguins landing during these six days was highly consistent, with four birds landing between 4.30pm and 7pm every day on the rock platform furthest from the beach, while three birds were seen landing on the first platform where the deployment was carried out. None of the observed birds carried a data logger. From 26 August, two motion triggered trail cameras were trained on the two rock platforms capturing penguins mainly between 6 and 9am in the morning and during the observation hours of 4-7pm at night.
Optimisation of the manufacturing process of a paediatric omeprazole enteric pellets suspension: Full Factorial Design
Creators: name: Rouaz-El-Hajoui, Khadija
name: Pérez-Lozano, Pilar
name: Fraschi-Nieto, Àlex
name: Mula-Roldán, Xavier
name: Suñé-Pou, Marc
name: Chiclana-Rodríguez, Blanca
name: Suñé-Negre, Josep María
name: García-Montoya, Encarnación
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Mental Health

description: The propose of the present study was to apply the design of experiments (DoE) to develop an omeprazole enteric pellets suspension for use in the paediatric population. This experimental study employed a Full Factorial Design for drug development, encompassing three factors (Aerosil® R972, cetostearyl alcohol, and Span 80) at two levels (2% and 6% for factor A (Aerosil® R972) and 2% and 4% for factors B and C (cetostearyl alcohol and Span 80, respectively)). Following the statistical optimization, the suspension F10 was formulated and subjected to a stability study for one month. The dissolution test results were suboptimal, achieving only an 22% release. Subsequently, eight additional suspensions were devised using hydrophilic oily vehicles (Labraphac Hydrophile WL 1219, Labrafil M2125 CS and Labrafil M 1944 CS) and excipients (Gelucire 44/14 and Aerosil® 200) to enhance the dissolution profile. Suspension F17 showed over 75% within 30 minutes, displaying superior sedimentation time when compared to all other formulations, along with effortless resuspension. The findings suggest that the optimal vehicle for the administration of omeprazole enteric pellets in suspension is the formulation comprising Labrafil M 1944 CS, Span 80, and Aerosil® 200. This study has paved the way for an oily suspension vehicle, opening new avenues of research for developing paediatric omeprazole formulations that fulfil gastro-resistance requirements.
Preclinical targeting of leukemia-initiating cells in the development future biologics for acute myeloid leukemia
Creators: name: Dong, Jiaxin
name: Konopleva, Marina
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Leukemia-initiating cells (LICs) are a critical subset of cells driving acute myeloid leukemia (AML) relapse and resistance to therapy. They possess unique properties, including metabolic, epigenetic, and microenvironmental dependencies, making them promising therapeutic targets. This review summarizes preclinical advances in targeting AML LICs, including strategies to exploit metabolic vulnerabilities, such as the reliance on oxidative phosphorylation (OXPHOS), through the use of mitochondrial inhibitors; target epigenetic regulators like DOT1L (Disruptor of Telomeric Silencing 1-like) to disrupt LIC survival mechanisms; develop immunotherapies, including CAR (chimeric antigen receptor) T-cell therapy, and bispecific antibodies; and disrupt LIC interactions with the bone marrow microenvironment by inhibiting supportive niches. LIC-targeted therapies hold significant promise for revolutionizing AML treatment by reducing relapse rates and improving long-term outcomes. However, challenges such as LIC heterogeneity, therapy resistance, and associated toxicity persist. Recent studies have illuminated the distinct biological characteristics of LICs, advancing our understanding of their behavior and vulnerabilities. These insights offer new opportunities to target LICs at earlier disease stages and to explore combination therapies with other targeted treatments, ultimately enhancing therapeutic efficacy and improving patient outcomes.
A national intervention to support frail older adults in primary care: a protocol for an adapted implementation framework
Creators: name: Sims-Gould, Joanie
name: Elliott, Jacobi
name: Tong, Catherine E.
name: Giguère, Anik
name: Mallinson, Sara
name: Stolee, Paul
Publisher: name: BioMed Central
Year: 2021

description: Background Older Canadians are high users of health care services, however the health care system is not well-designed to meet the complex needs of many older adults. Older persons often look to their primary care practitioners to assess their needs and coordinate their care. The intervention seeks to improve primary care for older persons living with frailty and will be implemented in six primary care clinics in three Canadian provinces. Presently, more than 1.6 million older Canadians are living with frailty, and this is projected to increase to 2.5 million within a decade (Canadian Frailty Network, Frailty Matters, 2020). The model will include frailty screening, an online portal to expedite referrals and improve coordination with community services, and several tools and techniques to support patient and family engagement and shared decision-making. Our project is guided by the Consolidated Framework for Implementation Research (CFIR) (Damschroder LJ, et al. Implement Scil, 4, 50, 2009). As others have done, we adapted the CFIR for our work. Our adapted framework combines elements of the socio-ecological model, key concepts from the CFIR, and elements from other implementation science frameworks. Nested within a broader mixed-method implementation study, the focus of this paper is to outline our guiding conceptual framework and qualitative methods protocol. Methods We will use the adapted CFIR framework to inform the data we collect and our analytic approach. Our work is divided into three phases: (1) baseline assessment of ‘usual care’; (2) tailoring and implementing a new primary care model; and (3) evaluation. In each of these phases we will engage in qualitative data collection, including clinical observations, focus groups, in-depth interviews and extensive field notes. At each site we will collect data with health care providers, key informants (e.g., executive directors), and rostered patients ≥ 70 years. We will engage in team-based analysis across multiple sites, three provinces and two languages through regular telephone conferences, a comprehensive analysis codebook, leadership from our Qualitative Working Group and a collective appreciation that “science is a team sport” (Clinical Orthopaedics and Related Research 471, 701-702, 2013). Discussion Outcomes of this research may be used by other research teams who chose to adapt the CFIR framework to reflect the unique contexts of their work, and clinicians seeking to implement our model, or other models of care for frail older patients in primary care. Trial Registration U.S. National Library of Medicine, NCT03442426 . Registered 22 February 2018– Retrospectively registered.
Revealing unforeseen diagnostic image features with deep learning by detecting cardiovascular diseases from apical four-chamber ultrasounds
Creators: name: Cheng, Li-Hsin
name: Bosch, Pablo B. J.
name: Hofman, Rutger F. H.
name: Brakenhoff, Timo B.
name: Bruggemans, Eline F.
name: van der Geest, Rob J.
name: Holman, Eduard R.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Image and Video Processing (eess.IV)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Medical Physics (physics.med-ph)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Background. With the rise of highly portable, wireless, and low-cost ultrasound devices and automatic ultrasound acquisition techniques, an automated interpretation method requiring only a limited set of views as input could make preliminary cardiovascular disease diagnoses more accessible. In this study, we developed a deep learning (DL) method for automated detection of impaired left ventricular (LV) function and aortic valve (AV) regurgitation from apical four-chamber (A4C) ultrasound cineloops and investigated which anatomical structures or temporal frames provided the most relevant information for the DL model to enable disease classification.
 Methods and Results. A4C ultrasounds were extracted from 3,554 echocardiograms of patients with either impaired LV function (n=928), AV regurgitation (n=738), or no significant abnormalities (n=1,888). Two convolutional neural networks (CNNs) were trained separately to classify the respective disease cases against normal cases. The overall classification accuracy of the impaired LV function detection model was 86%, and that of the AV regurgitation detection model was 83%. Feature importance analyses demonstrated that the LV myocardium and mitral valve were important for detecting impaired LV function, while the tip of the mitral valve anterior leaflet, during opening, was considered important for detecting AV regurgitation.
 Conclusion. The proposed method demonstrated the feasibility of a 3D CNN approach in detection of impaired LV function and AV regurgitation using A4C ultrasound cineloops. The current research shows that DL methods can exploit large training data to detect diseases in a different way than conventionally agreed upon methods, and potentially reveal unforeseen diagnostic image features.
Blinded analysis and interpretation of the multi-arm randomised clinical trial: An individually tailored self-management app-based intervention (selfBACK) versus a self-management web-based intervention (e-Help) or usual care in people with low back and neck pain referred to secondary care
Creators: name: Marcuzzi, Anna
name: Nordstoga, Anne Lovise
name: Bach, Kerstin
name: Gismervik, Sigmund
name: Nilsen, Tom Ivar Lund
name: Mork, Paul Jarle
Publisher: name: Zenodo
Year: 2022

description: Blinded analysis and interpretation of the multi-arm randomised clinical trial: An individually tailored self-management app-based intervention (selfBACK) versus a self-management web-based intervention (e-Help) or usual care in people with low back and neck pain referred to secondary care
Video abstract: Atlas of Inflammation Resolution. Overview.
Creators: name: Gupta, Shailendra
name: Hoch, Matti
name: Smita, Suchi
name: Cesnulevicius, Konstantin
name: Lescheid, David
name: Schultz, Myron
name: Wolkenhauer, Olaf
Publisher: name: Heel GmbH
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology

description: This is a tutorial video originally published on the web page "Atlas of Inflammation Resolution". It is part of the tutorials explaining how the Atlas was designed and how it works.Posted with permission of the authors.
title: In-situ observation of the wetting behavior during pw-cw-laser beam brazing
Creators: name: Janthur, F.-L.
name: Seffer, S.
name: Hermsdorf, J.
name: Overmeyer, L.
Publisher: name: TU Clausthal
Year: 2025
Subjects: subject: in-situ process observation
subject: laser beam brazing
subject: ns-pulsed laser deoxidation
subject: 620

description: In flux-free laser beam brazing, the surface oxides of the base material and the filler wire have a significant influence on the wetting behavior. In order to achieve optimal wetting results, the surface oxides must be removed. One approach is to use a ns-pulsed laser beam source to remove them prior to the cw-laser beam brazing process. To further improve wetting, the oxides on the filler wire also need to be removed. Therefore, the pw-beam source is now also used to remove the wire oxides during brazing in a combined pw-cw-laser beam brazing process. The ns-pulsed laser beam is applied in a line and a circle across the filler wire. The novel brazing process is observed using a high-speed camera. The camera's built-in illumination laser enables it to see through the bright process light, allowing in-situ observations of the wetting process. The experiments are conducted using a bead-on-plate brazing technique with aluminum AlSi12 filler wire and a copper Cu-OF base material. The position of the ns-pulsed laser beam is adjusted throughout the process zone, with the pulse energy varying from 120 μJ to 300 μJ. It can be observed that the ns-pulsed laser beam ablates the surface of the molten filler wire and exerts a pressure on the surface of the melt, thereby inducing a forced wetting behavior. The aim of the study is to understand the differences in wetting behavior and to obtain suitable parameters for future flux-free brazing experiments using this novel method.
description: Tagungsband 6. Symposium Materialtechnik: 20. bis 21. Februar 2025
Methanol als potentieller Zukunftskraftstoff für mittelschnelllaufende Großdieselmotoren
Creators: name: Rektorik, Petra
Publisher: name: Universität Rostock
Year: 2024
Subjects: subject: 500 Natural sciences
subject: 620 Engineering & allied operations
subject: 624 Structural and Environmental Engineering

description: Zur Einhaltung der Emissionsvorschriften wird für die Schifffahrtsindustrie Methanol als alternativer Kraftstoff diskutiert. In dieser Arbeit werden die Auswirkungen der chemischen und physikalischen Eigenschaften von Methanol auf das Einspritzsystem und das diffusive Brennverfahren mit Methanol untersucht. Ein neuartiger Hochdruckinjektor zur Direkteinspritzung von Methanol wird hydraulisch analysiert. Des Weiteren wird die Düseninnenströmung und das Strahlbild untersucht. Die Analyse des diffusiven Brennverfahrens mit Methanol wird an einem 32/44-Einzylinderforschungsmotor durchgeführt.
The targum (1923:Feb. 6 - 1923:Feb. 27)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1923

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Good practice guide for the coexistence of time and frequency signals with data traffic in Dense Wavelength Division Multiplexing (DWDM) fibre optic networks
Creators: name: Turza, Krzysztof
name: Smotlacha, Vladimir
name: Krehlik, Przemyslaw
name: Curri, Vittorio
name: Rosenbusch, Peter
Publisher: name: Zenodo
Year: 2022

description: Deliverable D5 of EMPIR project 18SIB06 "Advanced time/frequency comparison and dissemination through optical telecommunication networks", also known as Time and Frequency Over Optical Networks (TiFOON).
description: Funding: European Union (EU), Horizon 2020, EMPIR, 18SIB06, TiFOON, Advanced time/frequency comparison and dissemination through optical telecommunication networks
description: The objective of the work summarised in this paper is to identify good practices for the coexistence of time-frequency (T/F) signals with data traffic in Dense Wavelength Division Multiplexing (DWDM) fibre networks.

This paper focuses mainly on the specific effects associated with the transfer of bidirectional T/F signals multiplexed with unidirectionally transmitted data signals. The experiments carried out were designed to identify the main risks associated with this mode of transmission and to seek ways of reducing the potential negative interactions of the different signal types. In particular, the effects associated with stimulated Brillouin scattering and Rayleigh scattering were investigated. The effect of instability (lasing) of bidirectional amplifiers was explored, in particular in combinations including also Raman amplifiers (the most difficult case).

The information in this report is intended to provide a compendium of engineering knowledge necessary for the design, implementation and maintenance of hybrid networks for the transmission of T/F and data signals in a common DWDM system.
New Avenues for the Treatment of Huntington’s Disease
Creators: name: Kim, Amy
name: Lalonde, Kathryn
name: Truesdell, Aaron
name: Gomes Welter, Priscilla
name: Brocardo, Patricia S.
name: Rosenstock, Tatiana R.
name: Gil-Mohapel, Joana
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum and cortex. The first symptoms usually appear in mid-life and include cognitive deficits and motor disturbances that progress over time. Despite being a genetic disorder with a known cause, several mechanisms are thought to contribute to neurodegeneration in HD, and numerous pre-clinical and clinical studies have been conducted and are currently underway to test the efficacy of therapeutic approaches targeting some of these mechanisms with varying degrees of success. Although current clinical trials may lead to the identification or refinement of treatments that are likely to improve the quality of life of those living with HD, major efforts continue to be invested at the pre-clinical level, with numerous studies testing novel approaches that show promise as disease-modifying strategies. This review offers a detailed overview of the currently approved treatment options for HD and the clinical trials for this neurodegenerative disorder that are underway and concludes by discussing potential disease-modifying treatments that have shown promise in pre-clinical studies, including increasing neurotropic support, modulating autophagy, epigenetic and genetic manipulations, and the use of nanocarriers and stem cells.
Plant-derived active compounds as a potential nucleocapsid protein inhibitor of SARS-CoV-2: an in-silico study
Creators: name: Kashyap, Dharmendra
name: Roy, Rajarshi
name: Kar, Parimal
name: Jha, Hem Chandra
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2. This virus has a high mismatch repair proofreading ability due to its unique exonuclease activity, making it knotty to treat. The nucleocapsid protein can serve as a potential antiviral drug target, as this protein is responsible for multiple captious functions during the viral life cycle. Herein, we have investigated the potential to repurpose active antiviral compounds of plant origins for treating the SARS-CoV-2 infection. In the present study, we followed the molecular docking methodology to screen druggable natural plants’ active compounds against the nucleocapsid protein of SARS-CoV-2. The virtual screening of all 68 compounds revealed that the top seven active compounds, such as withanolide D, hypericin, silymarin, oxyacanthine, withaferin A, Acetyl aleuritolic acid, and rhein, exhibit good binding affinity with druggable ADME properties, toxicity, and Pass prediction. The stability of the docked complexes was studied by conducting molecular simulations of 100 ns. MM-GBSA calculated the binding free energy uncovered that withanolide D, hypericin, and silymarin result in highly stable binding conformations in three different sites of the nucleocapsid protein. However, further investigation is needed in order to validate the candidacy of these inhibitors for clinical trials. HighlightsNatural plants’ active compounds may aid in the inhibition of SARS-CoV-2 replication and COVID-19 therapeutics.Hypericin, silymarin, withanolide D, oxyacanthine, withaferin A, Acetyl aleuritolic acid, and rhein are effective against SARS-CoV-2 N protein.Studied natural plants’ active compounds could be useful against COVID-19 and its associated organs comorbidities.ADMET properties of selected compounds favor these compounds as druggable candidates. Natural plants’ active compounds may aid in the inhibition of SARS-CoV-2 replication and COVID-19 therapeutics. Hypericin, silymarin, withanolide D, oxyacanthine, withaferin A, Acetyl aleuritolic acid, and rhein are effective against SARS-CoV-2 N protein. Studied natural plants’ active compounds could be useful against COVID-19 and its associated organs comorbidities. ADMET properties of selected compounds favor these compounds as druggable candidates. Communicated by Ramaswamy H. Sarma
Culex (Culex) comorensis Brunhes
Creators: name: Harbach, Ralph E.
name: Wilkerson, Richard C.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Culicidae
Culex
Culex comorensis

description: Culex (Culex) comorensis Brunhes
subspecies comorensis Brunhes, 1977 —original combination: Culex (Culex) comorensis. Distribution: Anjouan and Mohéli Islands, Union of the Comoros and Ankaratra Massif, Madagascar (Brunhes 1977).
subspecies kartalae Brunhes, 1977 —original combination: Culex (Culex) comorensis ssp. kartalae. Distribution: Grande Comore [Union of the Comoros], Mayotte [overseas department of France] (Brunhes 1977).
Culex comorensis was described and named from specimens discovered on Anjouan Island, an autonomous high island that forms part of the Union of the Comoros. Brunhes (1977) indicated that it was also found on Mohéli Island and the Ankaratra Massif of Madagascar. Subspecies kartalae was briefly described and named in the same publication from specimens collected on Grande Comore Island. Brunhes pointed out morphological “peculiarities” of the male genitalia and larvae that distinguish the two forms. In the typical form, the subapical lobe of the gonocoxite bears a few minute setae at the bases of setae a-f; in the larva, head seta 13-C is long (0.6 mm), seta 1-S of the siphon usually has 4 pairs of setae on the posterior margin, the pecten consists of 10–14 spines (mean 11.2), and the dorsal and ventral anal papillae are equal in length. In subspecies kartalae, the subapical lobe of the gonocoxite bears a dense cluster of minute setae at the bases of setae a-f; the larva differs in having a short seta 13-C (0.2–0.3 mm), the siphon usually has 5 pairs of seta 1-S on the posterior margin, the pecten consists of 4–10 spines (mean 7.2) and the dorsal pair of anal papillae are longer than the ventral pair. The author, however, overlooked some additional important differences of the male genitalia. Subspecies kartalae differs from the typical form as follows: The ventral arms of the phallosome are longer and more slender, the dorsal arms are more distinctly minutely toothed and more sharply pointed, setae a, b, c and h of the subapical lobe are distinctly longer than seta g, setae a and b are stouter and more distinctly hooked apically and the insertion of seta c is borne mesad of setae a and b whereas it is inserted distal to these two setae in the typical form. The complexity of morphological distinctions and the geographical isolation are a clear indication that kartalae is a distinct species; thus, this form is hereby afforded specific status: Culex (Culex) kartalae Brunhes, 1977. Culex kartalae is currently listed as a species in the Encyclopedia of Life.
description: Published as part of Harbach, Ralph E. & Wilkerson, Richard C., 2023, The insupportable validity of mosquito subspecies (Diptera: Culicidae) and their exclusion from culicid classification, pp. 1-184 in Zootaxa 5303 (1) on page 84, DOI: 10.11646/zootaxa.5303.1.1, http://zenodo.org/record/8043342
การปรับตัวด้านภาษาและวัฒนธรรม ของนักศึกษานานาชาติในมหาวิทยาลัยมหิดล
Creators: name: ธิดาพร บุญเม่น
Publisher: name: วารสารวิพิธพัฒนศิลป์ โครงการบัณฑิตศึกษา สถาบันบัณฑิตพัฒนศิลป์
Year: 2022
Subjects: การปรับตัว
ภาษาและวัฒนธรรม
นักศึกษานานาชาติ

description: วารสารวิพิธพัฒนศิลป์, 2, 1, 52-66