cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer.
Creators: name: Laidley, Hannah M
name: Noble, David
name: Barnett, Gill C
name: Forman, Julia R
name: Bates, Amy M
name: Benson, Richard J
name: Jefferies, Sarah J
name: Jena, Rajesh
name: Burnet, Neil
Publisher: name: Apollo - University of Cambridge Repository
Year: 2018
Subjects: Spinal Cord
Humans
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Spinal Cord Diseases
Prognosis
Radiotherapy Dosage
Risk Factors
Longitudinal Studies
Follow-Up Studies
Adult
Aged
Middle Aged
Female
Male
Radiotherapy, Intensity-Modulated

description: BACKGROUND L’Hermitte’s sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high. METHODS 117 patients treated with TomoTherapy™ between 2008 and 2015 prospectively completed a side-effect questionnaire (VoxTox Trial Registration: UK CRN ID 13716). Baseline patient and treatment data were collected. Radiotherapy plans were analysed; mean and maximum spinal cord dose and volumes receiving 10, 20, 30 and 40 Gy were recorded. Dose variation across the cord was examined. These data were included in a logistic regression model. RESULTS 42 patients (35.9%) reported LS symptoms. Concurrent weekly cisplatin did not increase LS risk (p = 0.70, OR = 1.23 {95%CI 0.51 – 2.34}). Of 13 diabetic participants (9 taking metformin), only 1 developed LS (p = 0.025, OR = 0.13 {95%CI 0.051 – 3.27}). A refined binary logistic regression model showed that patients receiving unilateral radiation (p = 0.019, OR = 2.06 {95%CI 0.15 – 0.84}) were more likely to develop LS. Higher V40Gy (p = 0.047, OR = 1.06 {95%CI 1.00 – 1.12}), and younger age (mean age 56.6 vs 59.7, p = 0.060, OR = 0.96 {95%CI 0.92 – 1.00}) were associated with elevated risk of LS, with borderline significance. CONCLUSIONS In this cohort, concomitant cisplatin did not increase risk, and LS incidence was lower in diabetic patients. Patient age and dose gradients across the spinal cord may be important factors.
MC$^2$: Boosted AGN and star-formation activity in CIZA J2242.8+5301, a massive post-merger cluster at z=0.19
Creators: name: Sobral, David
name: Stroe, Andra
name: Dawson, William A.
name: Wittman, David
name: Jee, James
name: Röttgering, Huub
name: van Weeren, Reinout J.
name: Brüggen, Marcus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Cluster mergers may play a fundamental role in the formation and evolution of cluster galaxies. Stroe et al. (2014) revealed unexpected over-densities of candidate H$α$ emitters near the ~1 Mpc-wide shock fronts of the massive (~2x10$^{15}$M$_{\odot}$) "Sausage" merging cluster, CIZA J2242.8+5301. We used Keck/DEIMOS and WHT/AF2 to confirm 83 H$α$ emitters in and around the merging cluster. We find that cluster star-forming galaxies in the hottest X-ray gas and/or in the cluster sub-cores (away from the shock fronts) show high [SII]6716/[SII]6761 and high [SII]6716/H$α$, implying very low electron densities (<30x lower than all other star-forming galaxies outside the cluster) and significant contribution from supernovae, respectively. All cluster star-forming galaxies near the cluster centre show evidence of significant outflows (blueshifted Na D~200-300km/s), likely driven by supernovae. Strong outflows are also found for the cluster H$α$ AGN. H$α$ star-forming galaxies in the merging cluster follow the z~0 mass-metallicity relation, showing systematically higher metallicity (~0.15-0.2 dex) than H$α$ emitters outside the cluster (projected R>2.5 Mpc). This suggests that the shock front may have triggered remaining metal-rich gas which galaxies were able to retain into forming stars. Our observations show that the merger of impressively massive (~10$^{15}$M$_\odot$) clusters can provide the conditions for significant star-formation and AGN activity, but, as we witness strong feedback by star-forming galaxies and AGN (and given how massive the merging cluster is), such sources will likely quench in a few 100 Myrs.
description: Accepted for publication in MNRAS; 17 pages, 13 figures
(4208) Alexander Morrison
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Documentation on EU Legal & Regulatory landscape and the safety of alternative proteins for food
Creators: name: Alakomi, Hanna-Leena
name: Hyytiäinen-Pabst, Tiina
name: Shrestha, Marie
name: Agnarsson, Sveinn
name: Smárason, Birgir Örn
name: Trespeuch, Christophe
name: Berzin, Isaac
name: Korpela, Jaakko
name: Ekmay, Ricardo
name: Tillotson, Melissa
name: Schwarze, Ann-Kristin
name: Sveinsdóttir, Kolbrún
name: Paasi, Jaakko
Publisher: name: Zenodo
Year: 2020
Subjects: Food safety, regulation, novel food

description: In order to ensure food safety, it is important to consider the whole food chain from farm to fork. All the aspects and players within the supply chain, starting from the production of animal feed and primary production, through production, distribution and sales of food to the consumers influence food safety. In this open report, which builds on the novel foods regulation, ((EU) 2015/2283) as well as other regulations governing the production, safety and application of alternative proteins for food, knowledge gaps and regulatory safety barriers are highlighted with a focus on the three NextGen Proteins. Part of the work undertaken during writing of Deliverable D1.1 consisted of interviewing the industrial partners involved to gather their view and experiences. Based on these interviews the following main conclusions can be drawn: • Consumer health is the most important and therefore scientific information about e.g. toxicology, allergens, microbiological and chemical safety and quality of the new proteins is needed. • Traceability and labelling of the products (e.g. allergens) is important. • Associations can be beneficial in providing information and training. • Education of consumers and other stakeholders about new protein sources is needed. Information about sustainability, Eco footprint, LCA, safety and nutritional value should be available for these purposes. A formation of a harmonized coalition of alternative protein producers (similar to Sustainable Seafood Coalition, SSC) and stakeholders would be beneficial in sharing of information about sustainability and other relevant facts and data. • Some novel proteins might be more easily accepted by the consumers in feed applications (e.g. aquafeed, broilers, companion animals, pet food) compared to human food. • An organic certificate would benefit the industrial partners in food applications. • In food application the alternative proteins need to fulfil technological properties and specifications for the intended use. • Different retail trade operators can have their internal guidelines where they specify e.g. quality limits and requirements for the products. These can differ from the legislative limits.
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
Creators: name:  Sheahan, T.P.
name: Huang, E.
name: Edwards, C.E.
name: Dinnon, K.H., III
name: Hou, Y.J.
name: Gralinski, L.E.
name: Bryant, M.D.
name: Schäfer, A.
name: Leist, S.R.
name: Martinez, D.R.
name: Gully, K.L.
name: Adams, L.E.
name: West, A.
name: Yount, B.L., Jr
name: Choong, I.C.
name: Montgomery, S.A.
name: Baric, R.S.
name: Brown, A.J.
name: Glenn, J.S.
Publisher: name: Nature Research
Year: 2020

description: Coronaviruses are prone to emergence into new host species most recently evidenced by SARS-CoV-2, the causative agent of the COVID-19 pandemic1. Small animal models that recapitulate SARS-CoV-2 disease are desperately needed to rapidly evaluate medical countermeasures (MCMs)2,3. SARS-CoV-2 cannot infect wildtype laboratory mice due to inefficient interactions between the viral spike (S) protein and the murine ortholog of the human receptor, ACE24. We used reverse genetics5 to remodel the interaction between S and mACE2 resulting in a recombinant virus (SARS-CoV-2 MA) that could utilize mACE2 for entry. SARS-CoV-2 MA replicated in both the upper and lower airways of both young adult and aged BALB/c mice. Importantly, disease was more severe in aged mice, and showed more clinically relevant phenotypes than those seen in HFH4-hACE2 transgenic mice. We then demonstrated the utility of this model through vaccine challenge studies in immune competent mice with native expression of mACE2. Lastly, we show that clinical candidate interferon (IFN) lambda-1a can potently inhibit SARS-CoV-2 replication in primary human airway epithelial cells in vitro, and both prophylactic and therapeutic administration diminished replication in mice. Our mouse-adapted SARS-CoV-2 model demonstrates age-related disease pathogenesis and supports the clinical use of pegylated IFN lambda-1a treatment in human COVID-19 infections.
title: AI3SD Interview with Professor John Overington
Creators: name: Warr, Wendy
Publisher: name: University of Southampton
Year: 2020
Subjects: subject: AI3SD, Interview, Drug Repositioning, COVID-19

description: This interview forms part of our AI3SD Interview Series. Professor John Overington, the CIO of The Medicines Discovery Catapult, and a member of our Advisory Board was interviewed by Dr Wendy Warr in June 2020 as a precursor to his Guest Lecture on: Drug Repositioning for COVID-19
Quantum Holonomy Theory
Creators: name: Aastrup, Johannes
name: Grimstrup, Jesper M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present quantum holonomy theory, which is a non-perturbative theory of quantum gravity coupled to fermionic degrees of freedom. The theory is based on a C*-algebra that involves holonomy-diffeomorphisms on a 3-dimensional manifold and which encodes the canonical commutation relations of canonical quantum gravity formulated in terms of Ashtekar variables. Employing a Dirac type operator on the configuration space of Ashtekar connections we obtain a semi-classical state and a kinematical Hilbert space via its GNS construction. We use the Dirac type operator, which provides a metric structure over the space of Ashtekar connections, to define a scalar curvature operator, from which we obtain a candidate for a Hamilton operator. We show that the classical Hamilton constraint of general relativity emerges from this in a semi-classical limit and we then compute the operator constraint algebra. Also, we find states in the kinematical Hilbert space on which the expectation value of the Dirac type operator gives the Dirac Hamiltonian in a semi-classical limit and thus provides a connection to fermionic quantum field theory. Finally, an almost-commutative algebra emerges from the holonomy-diffeomorphism algebra in the same limit.
description: 76 pages, 6 figures
University Education and the Holistic Empowerment of Female Science Students in Enugu Education Zone, Nigeria
Creators: name: Maduka,, Blessing Chinyere
name: Christian,, Ngozi
name: Osuji,, Gregory Ekene
Publisher: name: GO JOURNAL
Year: 2024
Subjects: University education, female science students, intellectual empowerment, financial empowerment, socio-cultural empowerment, gender equality in education

description: The study investigated the impact of university education on the holistic empowerment of female science students in the Enugu Education Zone, Enugu State, Nigeria. The research was guided by three specific objectives: assessing intellectual empowerment, evaluating financial empowerment, and exploring socio-cultural empowerment among the students. Utilizing a quantitative research paradigm, the study employed a descriptive survey design. A simple random sampling technique was applied to select 480 female science students from the Faculty of Education across three universities. Data were collected using a well-structured questionnaire, validated by two specialists in Science Education and Measurement and Evaluation. The internal consistency of the instrument was confirmed through Cronbach's Alpha. Data analysis was conducted using the Statistical Package for Social Sciences (SPSS). Descriptive statistics, including mean and standard deviation, addressed the research questions, while inferential statistics, specifically an independent t-test, were used to test the hypotheses at a significance level of 0.05. Findings indicated that university education significantly contributes to the intellectual and financial empowerment of female science students but does not substantially enhance their socio-cultural empowerment. This suggests that in the Enugu Education Zone, cultural norms still favour men over women, regardless of educational attainment. The study recommends that female science students be afforded equal opportunities and fair treatment in all aspects of societal life, like their male counterparts
Baryon Cycling in the Low-Redshift Circumgalactic Medium: A Comparison of Simulations to the COS-Halos Survey
Creators: name: Ford, Amanda Brady
name: Werk, Jessica K.
name: Dave, Romeel
name: Tumlinson, Jason
name: Bordoloi, Rongmon
name: Katz, Neal
name: Kollmeier, Juna A.
name: Oppenheimer, Benjamin D.
name: Peeples, Molly S.
name: Prochaska, Jason X.
name: Weinberg, David H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyze the low-redshift (z~0.2) circumgalactic medium by comparing absorption-line data from the COS-Halos Survey to absorption around a matched galaxy sample from two cosmological hydrodynamic simulations. The models include different prescriptions for galactic outflows, namely hybrid energy/momentum driven wind (ezw), and constant winds (cw). We extract for comparison direct observables including equivalent widths, covering factors, ion ratios, and kinematics. Both wind models are generally in good agreement with these observations for HI and certain low ionization metal lines, but show poorer agreement with higher ionization metal lines including SiIII and OVI that are well-observed by COS-Halos. These discrepancies suggest that both wind models predict too much cool, metal-enriched gas and not enough hot gas, and/or that the metals are not sufficiently well-mixed. This may reflect our model assumption of ejecting outflows as cool and unmixing gas. Our ezw simulation includes a heuristic prescription to quench massive galaxies by super-heating its ISM gas, which we show yields sufficient low ionisation absorption to be broadly consistent with observations, but also substantial OVI absorption that is inconsistent with data, suggesting that gas around quenched galaxies in the real Universe does not cool. At impact parameters of <50 kpc, recycling winds dominate the absorption of low ions and even HI, while OVI almost always arises from metals ejected longer than 1 Gyr ago. The similarity between the wind models is surprising, since we show that they differ substantially in their predicted amount and phase distribution of halo gas. We show that this similarity owes mainly to our comparison here at fixed stellar mass rather than at fixed halo mass in our previous works, which suggests that CGM properties are more closely tied to the stellar mass of galaxies rather than halo mass.
description: 21 pages, 11 figures, submitted to MNRAS
Soybeans: Background for 1985 Farm Legislation
Creators: name: Hacklander, Duane
name: Gardiner, Walter
name: Hacklander, Duane
name: Gardiner, Walter
Publisher: name: Unknown
Year: 1984
Subjects: subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: International Relations/Trade
subject: soybeans
subject: meal
subject: oil
subject: farm programs
subject: policies

description: U.S. soybean production has increased rapidly and now ranks as the number two value crop. Much of the growth has come from foreign trade, but the United States faces increasing competition in the world markets for beans, meal, and oil. Soybean meal and oil also face strong competition from other high-protein feed sources and highly substitutable fats and oils in the edible oil market. Soybeans are a relatively new cash crop in the United States and have shifted to new production areas, being free of any acreage or production restrictions. Although soybeans are relatively free from direct Government programs, production levels are affected by other agricultural programs. Soybeans are supported by a loan rate which, in most years, has been below prices received by farmers. Issues for 1985 legislation will probably center on the determination of the support level and trade issues.
Sturnira mistratensis Contreras & Cadena 2000
Creators: name: Wilson, Don E.
name: Mittermeier, Russell A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Phyllostomidae
Sturnira
Sturnira mistratensis

description: 127. Mistratoan Yellow-shouldered Bat Sturnira mistratensis French: Sturnire de Mistrato / German: Mistrato-Gelbschulterfledermaus / Spanish: Sturniro de Mistraté Other common names: Mistrato Yellow-shouldered Bat Taxonomy. Sturnira mistratensis Contreras & Cadena, 2000, “ COLOMBIA. [Depart ment of] RISARALDA: Mistrato, corregimiento Puerto de Oro, 980 m.” This species 1s monotypic. Distribution. Known only from type locality in W Andes Range of C Colombia. Descriptive notes. Head-body 68 mm (tailless), ear 17 mm, hindfoot 16 mm, forearm 42-7 mm; weight 24 g. The Mistratoan Yellow-shouldered Bat is only known from the holotype. It is small and similar to the Little Yellow-shouldered Bat (S. Lilium). Dorsal fur is dark brown, becoming lighter toward side and venter. Dorsal hairs are tricolored, with dark brown base, subterminal whitish band, and dark brown band on tips (each band represents about one-third the hair’s length). It has gray spots on shoulders (epaulettes) from glandular secretions. Dorsal surfaces of femur,tibia, and feet are densely covered with long hairs. Tail membrane is very short and well-furred (long hairs). I' are faintly bicuspidate, and I, are tricuspidate and subequal in height to L,. Lingual cusps (metaconid and entoconid) of M, and M, are well defined and are separated by deep notch. M| also has accessory cuspid (paraconulid) between paraconid and metaconid, a distinctive characteristic. Habitat. Only recorded from type locality near 1000 m along Pacific slope of Western Andes Range. There is no specific information on the habitats at this locality, but it should include pre-montane rainforest. Food and Feeding. As other species of Sturnira, the Mistratoan Yellow-shouldered Bat is expected to be mainly frugivorous, maybe eating some pollen, nectar, and insects. Breeding. No information. Activity patterns. Mistratoan Yellow-shouldered Bats are nocturnal. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Data Deficient on The IUCN Red List. There is limited information about the Mistratoan Yellow-shouldered Bat and uncertainty aboutits relationships to other species of Sturnira. Bibliography. Contreras & Cadena (2000), Gardner (2008g), Pacheco & Patterson (1991), Velazco & Patterson (2013).
description: Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Phyllostomidae, pp. 444-583 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on pages 545-546, DOI: 10.5281/zenodo.6458594
(4203) Henry Beeton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Theoretical Tutorial of Supervised Causality Approach in Conceptual Cognitive Modeling.
Creators: name: Ghodratitoostani, Iman
Publisher: name: Zenodo
Year: 2023
Subjects: Conceptual Cognitive Model
Causality Model
Mediatory Model
Predictive Model

description: This technical report aims to provide the simplified theoretical knowledge needed to interpret and develop new mediatory models by non-experts in statistical modeling relying on their cognitive problems. Multi-mediatory models are employed to reveal the causality relationship between the cognitive conceptual model compartments, which must be supported with rational evidence. The inferential mediatory models can be developed in either IBM-SPSS, SAS, or R platform.
description: Technical Note in Theoretical Statistics
The Influence of Study Attitudes and Study Habits on the Academic Performance of the Students
Creators: name: Jhoselle Tus
Publisher: name: figshare
Year: 2020
Subjects: subject: 170103 Educational Psychology
subject: FOS: Psychology

description: Students' academic performance embodies an essential part of the constellation of factors determinant of student success. Also, it plays a very significant role in education, primarily as a concrete tool to assess the student's learning process. Psychologists and researchers have attempted to comprehend how students vary in processing, retaining, and retrieving learning information and have used various personality, attitudinal, cognitive styles, and ability measures. Thus, this study's primary purpose was to determine the students' study attitudes, study habits, and academic performance. Further, this examined the influence of study attitudes and study habits on their academic performance. The study respondents were the senior high school students in a Catholic School in Bulacan, Philippines. The Descriptive-correlation research method was utilized to describe the respondents' profile in terms of their study attitudes, study habits, and academic performance. A total of one hundred thirty (130) senior high school students participated in this study. The null hypothesis at .05 alpha level of significance was tested to determine the influence of study attitudes and study habits on the students' academic performance. The computed multiple regression analysis results revealed that study attitudes and study habits do not significantly affect senior high school students' academic performance.
MPEC 2023-T246 : 2023 TY10
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 TY10

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile
Creators: name: Sahin, M.
name: Lawrence, M.S.
name: Alexandrescu, S.
name: Getz, G.
name: Nellist, M.
name: Devinsky, O.
name: Zhu, Z.
name: Jozwiak, S.
name: Bongaarts, A.
name: Pisano, W.V.
name: Aronica, E., Amsterdam UMC
name: Kotulska, K.
name: Marron, D.
name: Hebert, Z.
name: Ligon, K.L.
name: Thiele, E.A.
name: Lidov, H.
name: Parker, J.S.
name: Taing, L.
name: Tyburczy, M.E.
name: Ellison, D.W.
name: Kim, J.
name: Godlewski, B.
name: Giannikou, K.
name: Kwiatkowski, D.J.
name: Meredith, D.M.
name: Roszkowski, M.
name: Winden, K.D.
name: Long, H.W.
name: Mandera, M.
Publisher: name: Springer Nature
Year: 2021

description: Subependymal giant-cell astrocytomas (SEGAs) are slow-growing brain tumors that are a hallmark feature seen in 5–10% of patients with Tuberous Sclerosis Complex (TSC). Though histologically benign, they can cause serious neurologic symptoms, leading to death if untreated. SEGAs consistently show biallelic loss of TSC1 or TSC2. Herein, we aimed to define other somatic events beyond TSC1/TSC2 loss and identify potential transcriptional drivers that contribute to SEGA formation. Paired tumor-normal whole-exome sequencing was performed on 21 resected SEGAs from 20 TSC patients. Pathogenic variants in TSC1/TSC2 were identified in 19/21 (90%) SEGAs. Copy neutral loss of heterozygosity (size range: 2.2–46 Mb) was seen in 76% (16/21) of SEGAs (44% chr9q and 56% chr16p). An average of 1.4 other somatic variants (range 0–7) per tumor were identified, unlikely of pathogenic significance. Whole transcriptome RNA-sequencing analyses revealed 190 common differentially expressed genes in SEGA (n = 16, 13 from a prior study) in pairwise comparison to each of: low grade diffuse gliomas (n = 530) and glioblastoma (n = 171) from The Cancer Genome Atlas (TCGA) consortium, ganglioglioma (n = 10), TSC cortical tubers (n = 15), and multiple normal tissues. Among these, homeobox transcription factors (TFs) HMX3, HMX2, VAX1, SIX3; and TFs IRF6 and EOMES were all expressed >12-fold higher in SEGAs (FDR/q-value < 0.05). Immunohistochemistry supported the specificity of IRF6, VAX1, SIX3 for SEGAs in comparison to other tumor entities and normal brain. We conclude that SEGAs have an extremely low somatic mutation rate, suggesting that TSC1/TSC2 loss is sufficient to drive tumor growth. The unique and highly expressed SEGA-specific TFs likely reflect the neuroepithelial cell of origin, and may also contribute to the transcriptional and epigenetic state that enables SEGA growth following two-hit loss of TSC1 or TSC2 and mTORC1 activation.
Improving Housing Instability to Reduce Adverse Health Outcomes for Honorably Discharged Veterans and Their Families Through the Creation of an Accountable Care Community in Cumberland County, North Carolina
Creators: name: Heindel, Gregory
name: Berdiel, Emilio
name: Fernando, Chamara
name: Merritt, Matthew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Housing instability is a well-recognized social determinant of health (SDOH). Housing costs can force individuals to spend large portions of income on housing and lead to issues paying rent, mortgages, overcrowding, and moving frequently and is associated with negative health outcomes. Veterans are at a higher risk of housing instability than the general population. In addition, veterans are overrepresented in the population within Cumberland County. An Accountable Care Community will be established in Cumberland County, to address the SDOH of economic instability which exacerbates housing instability. This will be accomplished through housing support initiatives, as well as mental, physical, and rehabilitative services. This includes direct subsidies to alleviate housing costs and a case management referral program. The ACC partners include, but are not limited to, the Department of Public Health, the Cumberland County Veteran Services Office, Fayetteville City Council, Salvation Army Emergency Shelters, Fayetteville Housing Authority and VA Healthcare Providers.
Une reforme antirepublicaine? Polemiques Autor de la Reforme Bérard (1921-1923)
Creators: name: Verneuil, Yves
Publisher: name: Gli Argonauti. Rivista di Studi Storico-Educativi e Pedagogici
Year: 2025
Subjects: Riforma Bérard; istruzione pubblica; insegnamento secondario; Reform Bérard; instruction publique; enseignement secondaire

description: Nel 1923, il ministro dell’Istruzione pubblica Léon Bérard impose una riforma dell’istruzione secondaria che rendeva obbligatorio il latino nelle prime quattro classi (dalla 6e alla 3e) e il greco nella 4e e nella 3e). Questa riforma consisteva nell’abolizione del corso “moderno” (senza latino) nei primi quattro anni dell’istruzione secondaria. Gli oppositori hanno definito la decisione ministeriale antidemocratica. Da un lato, perché la riforma avrebbe reso difficile il passaggio dall’istruzione primaria a quella secondaria e quindi accentuato la chiusura sociale delle scuole secondarie. Dall’altro, per l’autoritarismo con cui il ministro aveva deciso la riforma. Léon Bérard si difese insistendo sugli aspetti democratici della sua riforma. Secondo lui, i suoi avversari hanno politicizzato il dibattito perché non avevano argomenti pedagogici da proporre. Le misure adottate sono state ispirate dagli insegnanti delle scuole superiori, che sono i migliori giudici di ciò che è necessario per l’istruzione secondaria. Se la loro associazione condannasse infine la sua riforma, sarebbe anche per motivi politici.

En 1923, le ministre de l’Instruction publique Léon Bérard impose une réforme de l’enseignement secondaire qui rend obligatoire le latin dans les quatre premières classes (de la 6e à la 3e) et le grec en 4e et en 3e). Cette réforme revient à supprimer la filière « moderne » (sans latin) des quatre premières années de l’enseignement secondaire. Ses opposants ont qualifié la décision ministérielle d’anti-démocratique. D’une part, parce qu’à leurs yeux la réforme va rendre difficile les passages de l’enseignement primaire vers l’enseignement secondaire et va donc accentuer la fermeture sociale des lycées et des collèges. D’autre part parce qu’ils dénoncent l’autoritarisme avec lequel le ministre aurait décidé cette réforme. Léon Bérard se défend en insistant sur les aspects démocratiques de sa réforme. Selon lui, ses adversaires politisent le débat parce qu’ils n’ont pas d’arguments pédagogiques à lui opposer. Les mesures qu’il a prises lui aurait été inspirées par les professeurs de lycée, les mieux à même de juger de ce qu’il faut pour l’enseignement secondaire. Si leur association a finalement condamné sa réforme, ce serait aussi pour des raisons politiques.
description: Gli Argonauti. Rivista di Studi Storico-Educativi e Pedagogici, V. 4, N. 2 (2024)
HEALTH, OPPORTUNITY, PROSPERITY PROJECT (HOPP): AN ACCOUNTABLE CARE COMMUNITY ADDRESSING ECONOMIC STABILITY IN CUMBERLAND COUNTY, NC
Creators: name: Reardon, Laura
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The poverty rate in Cumberland County, NC is higher than the state average.  Promotion of economic stability among the low-income population in Cumberland County is of utmost importance in promoting health.  The Health, Opportunity, Prosperity, Project (HOPP), Accountable Care Community (ACC) aims to address economic stability with focus on employment and direct health education.  The three components of HOPP include strengthening unemployment insurance, business engagement and employment training and the Expanded Food and Nutrition Education Program (EFNEP).  Key partners involved in this ACC include the Cumberland County Department of Public Health, local businesses and community organizations, community members, policy makers, the NC Office of State Human Resources, NC Works Career Center, NC State University, the US Department of Labor and the NC Division of Employment Security.
Quantum state of the black hole interior
Creators: name: Brustein, Ram
name: Medved, A. J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: If a black hole (BH) is initially in an approximately pure state and it evaporates by a unitary process, then the emitted radiation will be in a highly quantum state. As the purifier of this radiation, the state of the BH interior must also be in some highly quantum state. So that, within the interior region, the mean-field approximation cannot be valid and the state of the BH cannot be described by some semiclassical metric. On this basis, we model the state of the BH interior as a collection of a large number of excitations that are packed into closely spaced but single-occupancy energy levels; a sort-of "Fermi sea" of all light-enough particles. This highly quantum state is surrounded by a semiclassical region that lies close to the horizon and has a non-vanishing energy density. It is shown that such a state looks like a BH from the outside and decays via gravitational pair production in the near-horizon region at a rate that agrees with the Hawking rate. We also consider the fate of a classical object that has passed through to the BH interior and show that, once it has crossed over the near-horizon threshold, the object meets its demise extremely fast. This result cannot be attributed to a "firewall", as the trauma to the in-falling object only begins after it has passed through the near-horizon region and enters a region where semiclassical spacetime ends but the energy density is still parametrically smaller than Planckian.
description: 28 pages, 2 figures
(4204) Robert Halliday Vance
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Inflation in a modified radiative seesaw model
Creators: name: Kashiwase, Shoichi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A radiative seesaw model with an inert doublet dark matter is a promising candidate which could explain the existence of neutrino masses, dark matter and baryon number asymmetry of the Universe, simultaneously. In addition to these issues, inflation should also be explained since the recent CMB observations suggest the existence of the inflationary era at the early stage of the Universe. Thus, we extend it by a complex scalar field with a specific potential. This scaler could also be related to the neutrino mass generation at a TeV scale. We show that the inflation favored by the CMB observations could be realized even if inflaton takes sub-Plankian values during inflation.
description: 4 pages, 3 figures, proceedings of The 2nd Toyama International Workshop on "Higgs as a Probe of New Physics 2015" (HPNP2015)
HEALTH, OPPORTUNITY, PROSPERITY PROJECT (HOPP): AN ACCOUNTABLE CARE COMMUNITY ADDRESSING ECONOMIC STABILITY IN CUMBERLAND COUNTY, NC
Creators: name: Eisenmann, Veronica
name: Reardon, Laura
name: Thompson, Tierra
name: Lee, Grace
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The poverty rate in Cumberland County, NC is higher than the state average.  Promotion of economic stability among the low-income population in Cumberland County is of utmost importance in promoting health.  The Health, Opportunity, Prosperity, Project (HOPP), Accountable Care Community (ACC) aims to address economic stability with focus on employment and direct health education.  The three components of HOPP include strengthening unemployment insurance, business engagement and employment training and the Expanded Food and Nutrition Education Program (EFNEP).  Key partners involved in this ACC include the Cumberland County Department of Public Health, local businesses and community organizations, community members, policy makers, the NC Office of State Human Resources, NC Works Career Center, NC State University, the US Department of Labor and the NC Division of Employment Security.
X-ray Insights into the Nature of PHL 1811 Analogs and Weak Emission-Line Quasars: Unification with a Geometrically Thick Accretion Disk?
Creators: name: Luo, B.
name: Brandt, W. N.
name: Hall, P. B.
name: Wu, Jianfeng
name: Anderson, S. F.
name: Garmire, G. P.
name: Gibson, R. R.
name: Plotkin, R. M.
name: Richards, G. T.
name: Schneider, D. P.
name: Shemmer, O.
name: Shen, Yue
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present an X-ray and multiwavelength study of 33 weak emission-line quasars (WLQs) and 18 quasars that are analogs of the extreme WLQ, PHL 1811, at z ~ 0.5-2.9. New Chandra 1.5-9.5 ks exploratory observations were obtained for 32 objects while the others have archival X-ray observations. Significant fractions of these luminous type 1 quasars are distinctly X-ray weak compared to typical quasars, including 16 (48%) of the WLQs and 17 (94%) of the PHL 1811 analogs with average X-ray weakness factors of 17 and 39, respectively. We measure a relatively hard ($Γ=1.16_{-0.32}^{+0.37}$) effective power-law photon index for a stack of the X-ray weak subsample, suggesting X-ray absorption, and spectral analysis of one PHL 1811 analog, J1521+5202, also indicates significant intrinsic X-ray absorption. We compare composite SDSS spectra for the X-ray weak and X-ray normal populations and find several optical-UV tracers of X-ray weakness; e.g., Fe II rest-frame equivalent width and relative color. We describe how orientation effects under our previously proposed "shielding-gas" scenario can likely unify the X-ray weak and X-ray normal populations. We suggest that the shielding gas may naturally be understood as a geometrically thick inner accretion disk that shields the broad line region from the ionizing continuum. If WLQs and PHL 1811 analogs have very high Eddington ratios, the inner disk could be significantly puffed up (e.g., a slim disk). Shielding of the broad emission-line region by a geometrically thick disk may have a significant role in setting the broad distributions of C IV rest-frame equivalent width and blueshift for quasars more generally.
description: 26 pages, 18 figures. ApJ in press
Health, Opportunity, Prosperity Project (HOPP): An Accountable Care Community Addressing Economic Stability in Cumberland County, NC
Creators: name: Thompson, Tierra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The poverty rate in Cumberland County, NC is higher than the state average. Promotion of economic stability among the low-income population in Cumberland County is of utmost importance in promoting health. The Health, Opportunity, Prosperity, Project (HOPP), Accountable Care Community (ACC) aims to address economic stability with focus on employment and direct health education. The three components of HOPP include strengthening unemployment insurance, business engagement and employment training and the Expanded Food and Nutrition Education Program (EFNEP). Key partners involved in this ACC include the Cumberland County Department of Public Health, local businesses and community organizations, community members, policy makers, the NC Office of State Human Resources, NC Works Career Center, NC State University, the US Department of Labor and the NC Division of Employment Security.
PROJECT KNOWLEDGE IS POWER (KIP): CREATION OF AN ACCOUNTABLE CARE COMMUNITY IN CUMBERLAND COUNTY TO IMPROVE MENTAL HEALTH STATUS BY INCREASING COLLEGE ENROLLMENT
Creators: name: Chiong, Cloie June
name: Griffin, Alexandria
name: Markert, Kellie
name: Kim, Isaiah
name: Krzastek, Donna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Education access and quality is one social determinant of health outlined by Healthy People 2030, with a key objective to increase the proportion of high school graduates in college the October after graduating. Those with a higher level of education have opportunities for jobs that can offer safer work environments and higher income, which can lead to mental stability. Without these opportunities, mental health can suffer due to stress, anxiety, and depression. The Accountable Care Community (ACC) intends to address mental health outcomes in Cumberland County through improving educational attainment via increasing the number of high schoolers who enroll in college after graduation. The priority population will be high school students ages 13-18. To achieve this, we hope to accomplish: 1) Expansion of Cumberland County’s dual enrollment program, the High School Connections; 2) Expansion of the Free Summer Meals program; and 3) Eliminating the SAT requirement.

Keywords: adolescence, mental health, education, Cumberland County, equity, social determinant of health, (SDoH), Accountable Care Community (ACC), food insecurity, high school, college, dual enrollment, SAT testing, Free Lunch
(4205) Samuel Vance
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
PROJECT KNOWLEDGE IS POWER (KIP): CREATION OF AN ACCOUNTABLE CARE COMMUNITY IN CUMBERLAND COUNTY TO IMPROVE MENTAL HEALTH STATUS BY INCREASING COLLEGE ENROLLMENT
Creators: name: Market, Kellie
name: Griffin, Alexandria
name: Isaiah, Kim
name: Krzastek, Donna
name: Chiong, Cloie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Education access and quality is one social determinant of health outlined by Healthy People 2030, with a key objective to increase the proportion of high school graduates in college the October after graduating. Those with a higher level of education have opportunities for jobs that can offer safer work environments and higher income, which can lead to mental stability. Without these opportunities, mental health can suffer due to stress, anxiety, and depression. The Accountable Care Community (ACC) intends to address mental health outcomes in Cumberland County through improving educational attainment via increasing the number of high schoolers who enroll in college after graduation. The priority population will be high school students ages 13-18. To achieve this, we hope to accomplish: 1) Expansion of Cumberland County’s dual enrollment program, the High School Connections; 2) Expansion of the Free Summer Meals program, and 3) Eliminating the SAT requirement.

Keywords: adolescence, mental health, education, Cumberland County, equity, social determinant of health, (SDoH), Accountable Care Community (ACC), food insecurity, high school, college, dual enrollment, SAT testing, Free Lunch
Oats: Background for 1985 Farm Legislation
Creators: name: Leath, Mack
name: Lin, William
name: Leath, Mack
name: Lin, William
Publisher: name: Unknown
Year: 1984
Subjects: subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: Livestock Production/Industries
subject: domestic use
subject: farm programs
subject: farm returns
subject: oats
subject: prices
subject: program effects
subject: world trade

description: Oats acreage has trended downward since the 1950's. Most oats production is fed to livestock on farms where produced, and exports are relatively small. Oats production and demand are in close balance. Price support loans have been available to oats producers since the late 1940's; however, deficiency and diversion payments were not made to them until 1983. Program costs in fiscal year 1983 were $12 million, about 1.3 percent of the 1982 crop value.
Universal targets for homomorphisms of edge-colored graphs
Creators: name: Guśpiel, Grzegorz
name: Gutowski, Grzegorz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: G.2.2
subject: 05C15, 05C60

description: A $k$-edge-colored graph is a finite, simple graph with edges labeled by numbers $1,\ldots,k$. A function from the vertex set of one $k$-edge-colored graph to another is a homomorphism if the endpoints of any edge are mapped to two different vertices connected by an edge of the same color. Given a class $\mathcal{F}$ of graphs, a $k$-edge-colored graph $\mathbb{H}$ (not necessarily with the underlying graph in $\mathcal{F}$) is $k$-universal for $\mathcal{F}$ when any $k$-edge-colored graph with the underlying graph in $\mathcal{F}$ admits a homomorphism to $\mathbb{H}$. We characterize graph classes that admit $k$-universal graphs. For such classes, we establish asymptotically almost tight bounds on the size of the smallest universal graph. For a nonempty graph $G$, the density of $G$ is the maximum ratio of the number of edges to the number of vertices ranging over all nonempty subgraphs of $G$. For a nonempty class $\mathcal{F}$ of graphs, $D(\mathcal{F})$ denotes the density of $\mathcal{F}$, that is the supremum of densities of graphs in $\mathcal{F}$. The main results are the following. The class $\mathcal{F}$ admits $k$-universal graphs for $k\geq2$ if and only if there is an absolute constant that bounds the acyclic chromatic number of any graph in $\mathcal{F}$. For any such class, there exists a constant $c$, such that for any $k \geq 2$, the size of the smallest $k$-universal graph is between $k^{D(\mathcal{F})}$ and $ck^{\lceil D(\mathcal{F})\rceil}$. A connection between the acyclic coloring and the existence of universal graphs was first observed by Alon and Marshall (Journal of Algebraic Combinatorics, 8(1):5-13, 1998). One of their results is that for planar graphs, the size of the smallest $k$-universal graph is between $k^3+3$ and $5k^4$. Our results yield that there exists a constant $c$ such that for all $k$, this size is bounded from above by $ck^3$.