cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Advances in Probabilistic Modelling: Sparse Gaussian Processes, Autoencoders, and Few-shot Learning
Creators: name: Bauer, Matthias
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Machine Learning
Probabilistic Modelling
Gaussian Processes
Variational Autoencoders
Few-shot Learning
Meta-Learning
Transfer Learning
Approximate Bayesian Inference
Variational Inference
Inductive Biases
Amortised Inference
Sparse Gaussian Processes
Invariance

description: Learning is the ability to generalise beyond training examples; but because many generalisations are consistent with a given set of observations, all machine learning methods rely on inductive biases to select certain generalisations over others. This thesis explores how the model structure and priors affect the inductiven biases of probabilistic models, and our ability to learn and make inferences from data. Specifically we present theoretical analyses alongside algorithmic and modelling advances in three areas of probabilistic machine learning: sparse Gaussian process approximations and invariant covariance functions, learning flexible priors for variational autoencoders, and probabilistic approaches for few-shot learning. As inference is rarely tractable, we discuss variational inference methods as a secondary theme. First, we disentangle the theoretical properties and optimisation behaviour of two widely used sparse Gaussian process approximations. We conclude that a variational free energy approximation is more principled and extensible and should be used in practice despite potential optimisation difficulties. We then discuss how general symmetries and invariances can be integrated into Gaussian process priors and can be learned using the marginal likelihood. To make inference tractable, we develop a variational inference scheme that uses unbiased estimates of intractable covariance functions. We then address the mismatch between aggregate posteriors and priors in variational autoencoders and propose a mechanism to define flexible distributions using a form of rejection sampling. We use this approach to define a more flexible prior distribution on the latent space of a variational autoencoder, which generalises to unseen test data and reduces the number of low quality samples from the model in a practical way. Finally, we propose two probabilistic approaches to few-shot learning that achieve state of the art results on benchmarks, building on multi-task probabilistic models with adaptive classifier heads. Our first approach combines a pre-trained deep feature extractor with a simple probabilistic model for the head, and can be linked to automatically regularised softmax regression. The second employs an amortised head model; it can be viewed to meta-learn probabilistic inference for prediction, and can be generalised to other contexts such as few-shot regression.
description: UK Engineering and Physics Research Council (EPSRC) DTA, Qualcomm Studentship in Technology, Max Planck Society
Intermediation der Forschungsinfrastruktur. Ein Rollenmodell für den Umgang mit einer komplexen Infrastrukturlandschaft
Creators: name: Cremer, Fabian
name: Wübbena, Thorsten
Publisher: name: Zenodo
Year: 2020
Subjects: subject: Intermediation
subject: Forschungsinfrastruktur
subject: Wissenschaftsmanagement
subject: http://tadirah.dariah.eu/vocab/?tema=45
subject: http://tadirah.dariah.eu/vocab/?tema=53
subject: http://tadirah.dariah.eu/vocab/?tema=40
subject: http://tadirah.dariah.eu/vocab/?tema=73
subject: http://tadirah.dariah.eu/vocab/?tema=79
subject: http://tadirah.dariah.eu/vocab/?tema=91

description: Der Beitrag beschreibt ein Rollenmodell für das Management einer komplexen Infrastrukturlandschaft aus Sicht geisteswissenschaftlicher Forschungseinrichtungen. Eine Mittelsperson makelt zwischen den Serviceangeboten der Infrastruktureinrichtungen und den Anforderungen der Forschenden. Diese Infrastrukturintermediation komprimiert oder übersetzt nicht nur Informationen, sondern übernimmt Verantwortung für die Konzeption und den Betrieb der Forschungsinfrastruktur sowie die Auswahl von Diensten und Tools, die Organisation des Betriebes und die Moderation der Nutzung. Die Verlagerung dieses Aufgabenbereiches auf ein/e Expert*in eröffnet a) größere Spielräume für die Forschenden, b) Zugänge zu Angeboten für die Forschungseinrichtungen und c) Nutzerkreise für die Infrastrukturanbieter und deren Organisation in Verbünden und Konsortien. Der Beitrag skizziert die Konzepte einer Infrastrukturmediation zweier außeruniversitärer Forschungseinrichtungen, die auch auf andere Strukturen und Wissenschaftseinrichtungen übertragbar sind.
description: {"references": ["W\u00fcbbena, Thorsten, Katrin Neumann, Fabian Cremer, Https://Orcid.Org/0000-0001-8251-9727, and Https://Orcid.Org/0000-0001-8172-6097. \"Intermediation Der Forschungsinfrastruktur. Ein Rollenmodell F\u00fcr Den Umgang Mit Einer Komplexen Infrastrukturlandschaft.\" DARIAH-DE, 2020. https://doi.org/10.20375/0000-000C-C6CC-F."]}
Multistep regulation of TFEB by MTORC1
Creators: name: Vega-Rubin-De-Celis, Silvia
name: Peña-Llopis, Samuel
name: Konda, Meghan
name: Brugarolas, James
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization. However, TFEBS211A localizes diffusely in both cytoplasm and nucleus and, as we show, retains regulation by MTORC1. Here, we report that endogenous TFEB is phosphorylated at S122 in an MTORC1-dependent manner, that S122 is phosphorylated in vitro by recombinant MTOR, and that S122 is important for TFEB regulation by MTORC1. Specifically, nuclear localization following MTORC1 inhibition is blocked by a S122D mutation (despite S211 dephosphorylation). Furthermore, such a mutation inhibits lysosomal biogenesis induced by Torin1. These data reveal a novel mechanism of TFEB regulation by MTORC1 essential for lysosomal biogenesis.
Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide in children with asthma
Creators: name: Park, Young A.
name: Park, Hyun Bin
name: Kim, Yoon Hee
name: Sul, In Sook
name: Yoon, Seo Hee
name: Kim, Hye Ran
name: Kim, Kyung Won
name: Kyu-Earn Kim
name: Sohn, Myung Hyun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Objective: Asthma is characterized by airway hyperresponsiveness (AHR), inflammation, and obstruction. AHR to stimuli that indirectly cause bronchial smooth muscle (BSM) contractions via release of endogenous mediators is thought to better reflect airway inflammation than AHR to stimuli that act directly on BSM. Fractional exhaled nitric oxide (FeNO) is a useful parameter for noninvasive clinical airway inflammation assessments. Accordingly, this study aimed to examine the relationships of mannitol and methacholine challenge test outcomes with FeNO and the influence of inhaled corticosteroid treatment in children with asthma. Methods: One hundred thirty-four asthmatic children (89 males; ages: 5–17 years, median: 9 years) underwent spirometry, FeNO measurement, serum total/specific IgE testing, and blood eosinophil count. All subjects were challenged with mannitol dry powder (MDP; AridolH, Pharmaxis, Australia) and methacholine at 7-day intervals. Data of steroid-treated and steroid-naïve children were compared. Results: Positive responses to MDP and methacholine challenge tests were observed in 74.6% and 67.2% of total subject group, respectively, and 72 children had positive response to both challenge tests. The median FeNO level, response-dose ratio (RDR) of PC20 methacholine, and RDR of PD15 MDP were significantly higher in the steroid-treated group than in the steroid-naïve group (p < 0.001, 0.226, and 0.004, respectively). FeNO levels associated significantly with PD15 MDP and RDR PD15 MDP in total subject populations (p = 0.016 and 0.003, respectively); however, a significant correlation between FeNO and RDR PD15 MDP was observed only in the steroid-naïve group. Conclusions: Compared with AHR to methacholine, AHR to MDP more closely reflected the level of FeNO in steroid-naïve asthmatic children.
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development.
Creators: name: Migale, Roberta
name: Neumann, Michelle
name: Mitter, Richard
name: Rafiee, Mahmoud-Reza
name: Wood, Sophie
name: Olsen, Jessica
name: Lovell-Badge, Robin
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Developmental Biology
subject: Developmental Biology

description: The transcription factor FOXL2 is required in ovarian somatic cells for female fertility. Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to distinctive outcomes, suggesting different roles across development. Here, we comprehensively investigated FOXL2's role through a multi-omics approach to characterize gene expression dynamics and chromatin accessibility changes, coupled with genome-wide identification of FOXL2 targets and on-chromatin interacting partners in somatic cells across ovarian development. We found that FOXL2 regulates more targets postnatally, through interaction with factors regulating primordial follicle formation and steroidogenesis. Deletion of one interactor, ubiquitin-specific protease 7 (Usp7), results in impairment of somatic cell differentiation, germ cell nest breakdown, and ovarian development, leading to sterility. Our datasets constitute a comprehensive resource for exploration of the molecular mechanisms of ovarian development and causes of female infertility.
Phlogothamnus lupias Linnavuori 1969
Creators: name: Hassan, Muhammad Asghar
name: Zhang, Jie
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Phlogothamnus
Phlogothamnus lupias

description: Phlogothamnus lupias Linnavuori, 1969
 Phlogothamnus lupias Linnavuori, 1969: 1179. Type locality: Republic of Congo (Odzala). Holotype male (MNHM).
 Distribution: Afrotropical. Republic of Congo (Odzala) (Linnavuori, 1969; Lemaître et al. 2017).
description: Published as part of Hassan, Muhammad Asghar, Zhang, Jie & Xing, Jichun, 2024, Taxonomic notes on the leafhopper genus Phlogothamnus Ishihara (Hemiptera: Cicadellidae: Deltocephalinae), with description of a new species from China, pp. 289-295 in Zootaxa 5432 (2) on page 291, DOI: 10.11646/zootaxa.5432.2.8, http://zenodo.org/record/10898783
title: Evaluating indoor air quality in buildings
Creators: name: Tang, Yaqin
name: Li, Wenzhuo
name: Marincioni, Valentina
Publisher: name: University of Southampton
Year: 2023

description: Indoor air quality plays a vital role in maintaining the health, comfort and well-being of building occupants. This report compares indoor PM2.5 and CO2 data, outdoor PM2.5 and NO2 data and weather station data against existing guidelines to analyse the differences in air quality between rooms and the potential causes of these conditions, in addition to explaining comparisons between pollutants and the frequency distribution of pollutant concentrations and exploring the possible causes. After illustrating the main findings, the building is modeled using DesignBuilder and the recommended interventions are found, briefly exploring the potential impact of the recommended measures on other aspects such as energy consumption, noise, thermal comfort etc.
Data
Creators: name: Grin, Eduardo José
Publisher: name: OSF Registries
Year: 2023

description: This article analyses how state capacities affect municipal achievements in the implementation of SDGs 3, 4, 6, 8, 13 and 16. This process and its connection with municipal state capacities remains little explored. The work shows how administrative, technical, institutional resources and politicians matters for the sustainable development implemented by Brazilian municipalities. The work argues that the localities that have more state capacity resources present better performances in the Agenda 2030. Still, if state capacities matter, this happens differently, not all of them are relevant in the same way and some do not behave as expected by the literature.
Phlogothamnus luteoguttatus Li 2011
Creators: name: Hassan, Muhammad Asghar
name: Zhang, Jie
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Phlogothamnus
Phlogothamnus luteoguttatus

description: Phlogothamnus luteoguttatus Li, 2011
 Phlogothamnus luteoguttatus Li, 2011 in Li, Dai & Xing, 2011: 182. Type locality: China (Hainan: Dongfang). Holotype male (GUGC).
 Distribution: Oriental. China (Hainan) (Li et al. 2011; Yao et al. 2022).
description: Published as part of Hassan, Muhammad Asghar, Zhang, Jie & Xing, Jichun, 2024, Taxonomic notes on the leafhopper genus Phlogothamnus Ishihara (Hemiptera: Cicadellidae: Deltocephalinae), with description of a new species from China, pp. 289-295 in Zootaxa 5432 (2) on page 291, DOI: 10.11646/zootaxa.5432.2.8, http://zenodo.org/record/10898783
Higher scores in the extraversion personality trait are associated with a functional polymorphism in the PER3 gene in healthy subjects
Creators: name: Jiménez, Karen M.
name: Pereira-Morales, Angela J.
name: Forero, Diego A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A polymorphism in the PER3 (period circadian clock 3) gene has been associated with neuropsychiatric disorders and endophenotypes. We evaluated the possible association of personality domains with the PER3 polymorphism in a sample of healthy subjects: 271 individuals were evaluated with the Big Five Inventory and genotyped for the PER3 Variable Number Tandem Repeat (VNTR) polymorphism. We found a significant association between the PER3 polymorphism and the extraversion personality trait (p = 0.0093). The 5/5 genotype carriers showed higher scores for extraversion. This is the first time that a significant association between the PER3 VNTR polymorphism and extraversion is reported.
Airway Hyperresponsiveness to Mannitol and Methacholine and Exhaled Nitric Oxide in Children with Asthma
Creators: name: Park, Young A
name: Park, Hyun Bin
name: Kim, Yoon Hee
name: Sul, In Sook
name: Yoon, Seo Hee
name: Kim, Hye Ran
name: Kim, Kyung Won
name: Kyu-Earn Kim
name: Sohn, Myung Hyun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology
subject: 60506 Virology

description: Airway Hyperresponsiveness to Mannitol and Methacholine and Exhaled Nitric Oxide in Children with Asthma
Simulation for Power
Creators: name: Prudon, Paul
name: Corbett, Brooklyn
name: Tangen, Jason M
Publisher: name: OSF Registries
Year: 2022

description: This component contains the information for our simulated power analysis. We generated estimated means and standard deviations based on Corbett and Tangen (in preparation), Towler et al., (2021), and Growns et al., (2022).
Reproduction in contaminated waters: impacts of the antidepressant pollutant fluoxetine on sexual selection in fish
Creators: name: de Melo, Gabriela Cavalcante
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 321503
subject: Reproduction
subject: FOS: Medical biotechnology
classificationCode: 310301
subject: Behavioural ecology

description: This thesis examines the environmental impacts of fluoxetine—a widely used antidepressant and environmental pollutant—on reproduction and sexual selection in fish. Fluoxetine (marketed as Prozac) targets the serotonergic system, a neurophysiological pathway conserved across species, that can potentially disrupt key traits in exposed wildlife. Through experiments with guppy populations exposed to environmentally relevant concentrations, this research demonstrates that fluoxetine disturbs male reproductive traits, influences female mate choice, and may have lasting effects even after exposure ends. Overall, these findings underscore the complex ecological and evolutionary implications of pharmaceutical pollution on critical reproductive behaviours and traits in fish.
Europium binding to humic substances extracted from deep underground sedimentary groundwater studied by time-resolved laser fluorescence spectroscopy
Creators: name: Saito, Takumi
name: Aoyagi, Noboru
name: Terashima, Motoki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry

description: Humic substances (HSs) are ubiquitous in various environments including deep underground and play an important role in the speciation and mobility of radionuclides. The binding of Eu3+, a chemical homologue of trivalent actinide ions, to HSs isolated from sedimentary groundwater at −250 m below the surface was studied by time-resolved laser fluorescence spectroscopy combined with parallel factor analysis (PARAFAC) as a function of pH and salt concentration. PARAFAC modeling reveals the presence of multiple factors that correspond to different Eu3+ species. These factors resemble those observed for Eu3+ binding to HSs from surface environments; however, detailed comparison shows that there are some particularities in Eu3+ binding to the deep groundwater HSs. The distribution coefficients (Kd) of Eu3+ binding to the HSs calculated from the PARAFAC modeling exhibits a rather strong salt effect. At 0.01 M NaClO4, the Kd values are relatively large and comparable to those to the surface HSs; they are decreaed at 0.1 M NaClO4 by more than an order of the magnitude. The Kd values are larger for the humic acid fraction of the deep underground HSs than the fulvic acid fraction over the entire range of pH and salt concentration investigated in this study.
Quality of life in long-term and very long-term cancer survivors versus population controls in Germany
Creators: name: Arndt, Volker
name: Koch-Gallenkamp, Lena
name: Jansen, Lina
name: Bertram, Heike
name: Eberle, Andrea
name: Holleczek, Bernd
name: Schmid-Höpfner, Sieglinde
name: Waldmann, Annika
name: Zeissig, Sylke Ruth
name: Brenner, Hermann
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Background: With the increasing number and diversity of cancer survivors, studies of survivors’ physical, emotional, and social health are of growing importance. While there is a growing body of literature on the quality of life (QoL) of cancer patients during the early years past diagnosis, less is known regarding QoL in long-term survivors (LTS) (5 + years past diagnosis) and particularly in very long-term survivors (VLTS) (10 + years past diagnosis). The objective of our study is to: (1) compare QoL of long-term cancer survivors and population norms; and (2) assess whether any deficits in QoL of survivors observed 5–10 years past diagnosis persist beyond the 10th year past diagnosis. Methods: In total 6952 long-term cancer survivors (5–16 years past diagnosis of breast, colorectal, or prostate cancer) from Germany recruited in the context of the population-based CAESAR + study were compared with 1878 population-based controls without a history of cancer. QoL was assessed with the EORTC QLQ-C30. Differences in QoL between survivors and controls were assessed via multiple regression while controlling for age, gender, education, and case mix for survivors 5–9 years and 10 + years past diagnosis separately. Results: Overall QoL in long-term cancer survivors was comparable to population norms but specific deficits in social, role, emotional, cognitive, and physical functioning and symptoms such as insomnia, fatigue, dyspnea, constipation, diarrhea, and financial difficulties were more prevalent in LTSs. Detriments in QoL persisted during the observation period and affected particularly cancer survivors at younger ages (<50 years). Non-significant aggravations in QoL with longer time since diagnosis were observed in very young and very old cancer survivors. Conclusions: Detriments in health-related quality of life persist over more than a decade and affect predominantly younger patients. Improvements both in early and long-term follow-up care of cancer survivors seem warranted.
ETS State Aid Draft Guidelines 2020 - Position paper Università degli studi di Padova, DiPIC – Osservatorio europeo sugli aiuti di Stato - Centro studi di economia e tecnica dell'energia Giorgio Levi Cases
Creators: name: Cortese, Bernardo
Publisher: name: Zenodo
Year: 2020
Subjects: EU Law
State Aid
ETS

description: Consultazione sulla revisione delle linee guida sugli aiuti per il sistema ETS (sistema di scambio delle quote di emissioni di gas a effetto serra) Position paper Università degli studi di Padova, DiPIC – Osservatorio europeo sugli aiuti di Stato - Centro studi di economia e tecnica dell'energia Giorgio Levi Cases
REMODEL/CrD/DisseminationPosters.pdf/jpeg
Creators: name: Yasemin ERTAN
Publisher: name: Zenodo
Year: 2023
Subjects: Dissemination
Communication
REMODEL

description: These posters have been prepared within the scope of work package 5 of the REMODEL Project, funded by the European Union’s Horizon Europe research and innovation program under Grant Agreement No 101079203. The posters are used to support communication activities of REMODEL and give brief information about the REMODEL project's overall methodology, work packages of the REMODEL project, business model innovation laboratory to be established at Bursa Uludağ University (BUU) and actions for BUU research capacity building.
Metacognitive Domains Are Not Aligned along a Dimension of Internal-External Information Source
Creators: name: Arbuzova, Polina
name: Maurer, Lisa K.
name: Filevich, Elisa
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Metacognition
subject: Domain-general
subject: Domain-specific
subject: M-ratio
subject: 610 Medizin und Gesundheit
subject: 150 Psychologie

description: It is still debated whether metacognition, or the ability to monitor our own mental states, relies on processes that are “domain-general” (a single set of processes can account for the monitoring of any mental process) or “domain-specific” (metacognition is accomplished by a collection of multiple monitoring modules, one for each cognitive domain). It has been speculated that two broad categories of metacognitive processes may exist: those that monitor primarily externally generated versus those that monitor primarily internally generated information. To test this proposed division, we measured metacognitive performance (using m-ratio, a signal detection theoretical measure) in four tasks that could be ranked along an internal-external axis of the source of information, namely memory, motor, visuomotor, and visual tasks. We found correlations between m-ratios in visuomotor and motor tasks, but no correlations between m-ratios in visual and visuomotor tasks, or between motor and memory tasks. While we found no correlation in metacognitive ability between visual and memory tasks, and a positive correlation between visuomotor and motor tasks, we found no evidence for a correlation between motor and memory tasks. This pattern of correlations does not support the grouping of domains based on whether the source of information is primarily internal or external. We suggest that other groupings could be more reflective of the nature of metacognition and discuss the need to consider other non-domain task-features when using correlations as a way to test the underlying shared processes between domains.
DNA Methylation Profiling of Trisomy 21 Patients With Breast Cancer
Creators: name: Alresheq, Sara Izzat M. I.
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Down syndrome (DS), also called trisomy 21 (T21) occurs due to an extra full chromosome 21 and is the most common chromosomal anomaly in humans. DS is linked to various phenotypical features, developmental retardation, and medical complications. The malignancy profile in DS is unique, as DS patients have significant lower frequency of developing solid tumors compared to the normal population. Breast cancer (BC), for example, is almost absent in DS patients with a frequency of 0.7% compared to 12.5% in the general population. Epigenetic dysregulation is a driving factor of breast cancer progression. Thus, we hypothesized that novel epigenetic factors are associated with the lower breast cancer frequency observed in women with T21. In order to test our hypothesis, we analyzed the methylation profile of T21 women with breast cancer (T21-BC), T21 women without breast cancer (T21-BCF), and women with normal karyotype diagnosed with breast cancer (NK-BC, n=75). Furthermore, the gene expression changes previously reported in the transcriptomic study performed by Mégarbané et al. were compared to the differentially methylated sites/regions from this study. As a result, on the regional level 5 genes that are differentially expressed in the RNA seq data were identified to have differentially methylated promoters in T21-BCF patients in the context of T21-BC Vs T21-BCF. In addition, an enrichment for the Wnt signalling pathway was observed for the 564 CpG sites differentially methylated and corresponding to differentially expressed genes in the T21-BC vs. T21-BCF analysis.
title: Weidelgras :
title: Richtlinien für die Durchführung der Prüfung auf Unterscheidbarkeit, Homogenität und Beständigkeit.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2006

description: Zweck dieser Richtlinien („Prüfungsrichtlinien“) ist es, die in der Allgemeinen Einführung (Dokument TG/1/3) und deren verbundenen TGP-Dokumenten enthaltenen Grundsätze in detaillierte praktische Anleitung für die harmonisierte Prüfung der Unterscheidbarkeit, der Homogenität und der Beständigkeit (DUS) umzusetzen und insbesondere geeignete Merkmale für die DUS-Prüfung und die Erstellung harmonisierter Sortenbeschreibungen auszuweisen.
Phlogothamnus maculiceps Ishihara 1961
Creators: name: Hassan, Muhammad Asghar
name: Zhang, Jie
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Phlogothamnus
Phlogothamnus maculiceps

description: Phlogothamnus maculiceps Ishihara, 1961
 Phlogothamnus maculiceps Ishihara, 1961: 248. Type locality: Thailand. Holotype male (BMNH).
 Distribution: Oriental. China (Hainan, Sichuan, Yunnan) (Li & Song, 2010; Li et al. 2011; Yao et al. 2022), India (Uttarakhand, Dehradun) (Viraktamath & Yeshwanth 2020; Rajgopal et al. 2022), Thailand (Ishihara, 1961).
description: Published as part of Hassan, Muhammad Asghar, Zhang, Jie & Xing, Jichun, 2024, Taxonomic notes on the leafhopper genus Phlogothamnus Ishihara (Hemiptera: Cicadellidae: Deltocephalinae), with description of a new species from China, pp. 289-295 in Zootaxa 5432 (2) on page 291, DOI: 10.11646/zootaxa.5432.2.8, http://zenodo.org/record/10898783
Dichiarazione attività arruolamento dello studio clinico dal titolo: Impatto di uno score di stratificazione del rischio sull¿outcome di pazienti con trapianto di fegato colonizzati da Enterobatteri resistenti ai carbapenemi: uno studio osservazionale
Creators: name: Agnese, valentina
Publisher: name: Zenodo
Year: 2024

description: Lo studio "Impatto di uno score di stratificazione del rischio sull¿outcome di pazienti con trapianto di fegato colonizzati da Enterobatteri resistenti ai carbapenemi: uno studio osservazionale" è uno studio no profit promosso dall' Alma Mater Studiorum Università degli Studi di Bologna.

L'IRCCS ISMETT partecipa allo studio da aprile 2023 ed ha arruolato finora 10 pazienti.
Strategies to Aid International Students Well-Being: The Use of Education City Multimedia Manual
Creators: name: Bamashmous, Alaa Omar Mohammed
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 44
subject: Human society

description: International students’ well-being is affected by their ability to adapt to their new campus environment. There are different strategies that investigate methods to help international students' adaptation. One of these strategies is to use multimedia tools to assist in adjusting to new environments, especially the use of multimedia manuals as guiding tools. This research project creates a multimedia manual that acts as a guide to Education City (EC) in Qatar for international students, bearing in mind that currently, there is no similar multimedia guide. The researcher began by reviewing literature regarding the use of multimedia tools as guiding methods in different fields. To create the Education City Multimedia Manual (ECMM), an autoethnographic method was used to identify students' concerns and allow them to find answers in the manual. The ECMM is created in a PDF and mp4 format using Canva and Adobe Illustrator tools. A discussion of the manual’s method of delivery is provided, in addition to section descriptions and the EC locations they introduce. This research project contributes to the study of multimedia manuals as a students’ aid to adapting to new environments.
Can the meiotic sex ratio explain the sex ratio bias in adult populations in the dioicous moss Drepanocladus lycopodioides?
Creators: name: Bisang, Irene
name: Hedenäs, Lars
name: Cronberg, Nils
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Sex ratio variation is commonly observed in natural populations of many organisms with separate sexes and genetic sex determination, including bryophytes. Most bryophyte populations exhibit female-skewed expressed adult sex ratios, generally inferred from counts of sexually mature plants. For the rarely sexually reproducing perennial dioicous moss Drepanocladus lycopodioides, we showed that a female bias also exists in the genetic adult sex ratio, using a specifically designed molecular sex-associated marker. Here, we investigated whether the meiotic spore sex ratio contributes to the observed bias in genetic adult sex ratio in natural populations. Earlier attempts to study meiotic sex ratios have involved commonly cultivated ruderals that rapidly express sex in the laboratory. We established single-spore cultures from field-collected sporophytes from these populations and used the marker to assess the sex of individual sporelings. Spore germinability was (near) complete, and mortality among sporelings was virtually absent. The true meiotic sex ratio did not differ from equality, but strongly differed both from the observed genetic sex ratios in the natural adult populations, and from the European scale genetic sex ratio. We conclude that the biased population sex ratios in this species arise at life cycle stages after spore germination. Sexual dimorphism may selectively favour female proliferation during some phase of gametophyte development. Based on methodological progress, we successfully used a perennial study species with rare sexual reproduction, which significantly broadens the life history spectrum investigated in bryophyte sex ratio studies.
Kultgen_Disseration_Final.pdf
Creators: name: Kultgen, Derek William
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 409999
subject: Other engineering not elsewhere classified

description: A 1/28th 350MW scaled High Temperature Gas Reactor test facility was constructed to simulate depressurized loss of forced cooling (DLOFC) accident scenarios. Temperature, pressure, and oxygen concentration data collected during the experimental campaign provided insight to the mixing/stratification phenomena that occurs during the entirety of the DLOFC process. The test facility was replicated with system code and computational fluid dynamics using RELAP5MOD3.3 and COMSOL5.6, respectively. Leveraging boundary conditions and semi-empirical formulations from experiments, the test facility was digitally replicated and simulated results were compared against test data.
Phlogothamnus productus Li & Xing 2011
Creators: name: Hassan, Muhammad Asghar
name: Zhang, Jie
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Phlogothamnus
Phlogothamnus productus

description: Phlogothamnus productus Li & Xing, 2011
 Phlogothamnus productus Li & Xing, 2011 in Li, Dai & Xing, 2011: 183. Type locality: China (Hainan). Holotype male (GUGC).
 Distribution: Oriental. China (Hainan) (Li et al. 2011; Yao et al. 2022).
description: Published as part of Hassan, Muhammad Asghar, Zhang, Jie & Xing, Jichun, 2024, Taxonomic notes on the leafhopper genus Phlogothamnus Ishihara (Hemiptera: Cicadellidae: Deltocephalinae), with description of a new species from China, pp. 289-295 in Zootaxa 5432 (2) on page 292, DOI: 10.11646/zootaxa.5432.2.8, http://zenodo.org/record/10898783
Circadian Modulation on T-wave Alternans Activity in Chronic Heart Failure Patients
Creators: name: Martín-Yebra, Alba
name: Caiani, Enrico G
name: Laguna, Pablo
name: Monasterio, Violeta
name: Martínez, Juan Pablo
Publisher: name: figshare
Year: 2017
Subjects: Biological Engineering

description: Conference paper: Computing in Cardiology 2015; 42:845-848. Alba Martín-Yebra, Enrico G Caiani, Pablo Laguna, Violeta Monasterio, Juan Pablo Martínez
Phlogothamnus pseudorugosus Dietrich, Nguyen & Pham 2020
Creators: name: Hassan, Muhammad Asghar
name: Zhang, Jie
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Phlogothamnus
Phlogothamnus pseudorugosus

description: Phlogothamnus pseudorugosus Dietrich, Nguyen & Pham, 2020
 Phlogothamnus pseudorugosus Dietrich, Nguyen & Pham, 2020: 255. Type locality: Vietnam (Ninh Binh, Cuc Phuong NP center). Holotype male (VNMN).
 Distribution: Oriental. Vietnam (Ninh Binh, Cuc Phuong NP center) (Dietrich et al. 2020; Yao et al. 2022).
description: Published as part of Hassan, Muhammad Asghar, Zhang, Jie & Xing, Jichun, 2024, Taxonomic notes on the leafhopper genus Phlogothamnus Ishihara (Hemiptera: Cicadellidae: Deltocephalinae), with description of a new species from China, pp. 289-295 in Zootaxa 5432 (2) on page 292, DOI: 10.11646/zootaxa.5432.2.8, http://zenodo.org/record/10898783
Simulation optimization applied to production scheduling in the era of industry 4.0: A review and future roadmap
Creators: name: Ghasemi, Amir
name: Farajzadeh, Fatemeh
name: HEAVEY, CATHAL
name: Fowler, John
name: T. Papadopoulos, Chrissoleon
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 40
subject: Engineering

description: Production Scheduling (PS) is an essential paradigm within supply and manufacturing systems and an important element of sustainable development. PS, mainly known for its horizontal effects within the operational decision level, directly impacts both tactical and strategical levels of decision-making. In other words, an optimally designed and utilized PS module could bring efficiency towards the whole supply chain network of many manufacturing systems. Simulation Optimization (SO), as a growing Decision Support Tool (DST), provides a methodology required to drastically improve the efficiency of industrial systems. Thus, in this article, we review the existing research on SO Applied to PS (SOAPS), within the context of wider adaption of Industry 4.0 (known as the fourth industrial revolution). Firstly, relevant articles are examined and reviewed to position the research and develop research questions that enable the highlighting of research gaps. Then, a methodology was created based on: the studied PS problem features, proposed optimization frameworks, executed simulation tools, the SO architectures and the experimentation and validation strategies used. Finally, we investigate how Industry 4.0 could enhance the existing research on SOAPS to provide real-time and efficient SO-based DSTs for PS modules within modern manufacturing systems.
T-wave Alternans Predicts ICD Discharge in MADIT II Patients with Elevated Resting Heart Rate
Creators: name: Monasterio, Violeta
name: Martínez, Juan Pablo
name: McNitt, Scott
name: Laguna, Pablo
name: Moss, Arthur J
name: Zareba, Wojciech
name: Jean-Philippe Couderc
Publisher: name: figshare
Year: 2017
Subjects: subject: Biological Engineering
subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: Conference paper: Violeta Monasterio, Juan Pablo Martínez, Scott McNitt, Pablo Laguna, Arthur J Moss, Wojciech Zareba, Jean-Philippe Couderc.Computing in Cardiology 2013; 40:603-606.
ГЕНОМНОЕ РЕДАКТИРОВАНИЕ: МОРАЛЬНЫЕ АСПЕКТЫ
Creators: name: Зайниддинова, Замира
name: Атамуратова, Феруза
Publisher: name: Zenodo
Year: 2024

description: Чем стремительнее развивается генетика, тем больше этических проблем возникает вокруг ее достижений. В последние годы быстрое развитие генетики и геномики в мире, а именно технологии CRISPR-Cas9, позволяющей модифицировать ДНК организмов с высокой точностью и простотой использования вызывает много вопросов и противоречий как между биологами, генетиками, так и представителями различных гуманитарных наук. Искусственное вторжение в биологию человека актуализирует необходимость исследования этических проблем «совершенствования» человека.
The Role of Purkinje Automaticity as an Arrhythmia Mechanism in Hyperkalaemia
Creators: name: Monasterio, Violeta
name: Carro, Jesús
name: Pueyo, Esther
name: Rodríguez-Matas, José F
Publisher: name: figshare
Year: 2017
Subjects: Biological Engineering

description: Conference paper: Violeta Monasterio, Jesús Carro, Esther Pueyo, José F Rodríguez. Computing in Cardiology 2015; 42:873-876.
title: Analysis of the Similarity between Injection Molding Simulation and Experiment
Creators: name: Knoll, Julia
name: Heim, Hans-Peter
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: injection molding
subject: injection molding flow simulation
subject: Moldflow®
subject: similarity analysis
subject: 600
subject: 670
subject: Spritzgießen
subject: Numerische Strömungssimulation
subject: Moldflow Design
subject: Experiment
subject: Analyse

description: Gefördert durch den Publikationsfonds der Universität Kassel
title: Mass timber carbon solutions - reducing life-cycle carbon emissions with mass timber construction
Creators: name: Anselmo, Agostino
name: Vallejo, Juan A.
Publisher: name: University of Southampton
Year: 2023

description: Mass timber construction is gaining momentum every year, driven by the urgency of reducing carbon emissions in the construction world. Some of its advantages are structural performance, ease of construction, and a variety of options to suit different applications. One of the biggest risks in timber buildings LCAs is confusion over biogenic carbon. LCAs and dynamic thermal simulations were used to compare alternative scenarios focusing on material substitutions: changing the materials of the structure, slabs, external walls and core to certain mass timber solutions can deliver significant embodied and operational carbon reductions. The results show how a careful mass timber design can lead to significant carbon savings.
title: Enhancing Scientific Research Through Instrument Metadata and PIDs – Tackling the “How Might We” Challenges
Creators: name: Habermann, Ted
name: Robinson, Erin
name: Jones, Jamaica
name: Metadata Game Changers (United States)
Publisher: name: DataCite
publisherIdentifier: https://ror.org/04wxnsj81
publisherIdentifierScheme: ROR
Year: 2024

description: The Persistent Identifiers (PIDs) for Instruments Community Dialogue, hosted by DataCite and Metadata Game Changers, brought together a diverse group of experts to explore how PIDs can transform the identification of scientific instruments and the data they collect. With over 45 attendees from life sciences, astronomy, and other domains, the discussion highlighted the shared need for improving reproducibility, traceability, and metadata practices in scientific research and for clarity on roles and responsibilities for building and maintaining capacity.
This blog post summarizes the discussions and focuses on the key "How Might We" themes from the presentations and breakout groups to help focus future efforts. These themes point to practical steps the research community can take to address the challenges of creating and managing connected instrument metadata.
Multitask Quantile Regression Under the Transnormal Model
Creators: name: Jianqing Fan
name: Lingzhou Xue
name: Zou, Hui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: We consider estimating multitask quantile regression under the transnormal model, with focus on high-dimensional setting. We derive a surprisingly simple closed-form solution through rank-based covariance regularization. In particular, we propose the rank-based ℓ1 penalization with positive-definite constraints for estimating sparse covariance matrices, and the rank-based banded Cholesky decomposition regularization for estimating banded precision matrices. By taking advantage of the alternating direction method of multipliers, nearest correlation matrix projection is introduced that inherits sampling properties of the unprojected one. Our work combines strengths of quantile regression and rank-based covariance regularization to simultaneously deal with nonlinearity and nonnormality for high-dimensional regression. Furthermore, the proposed method strikes a good balance between robustness and efficiency, achieves the “oracle”-like convergence rate, and provides the provable prediction interval under the high-dimensional setting. The finite-sample performance of the proposed method is also examined. The performance of our proposed rank-based method is demonstrated in a real application to analyze the protein mass spectroscopy data. Supplementary materials for this article are available online.
A Bayesian Approach to Graphical Record Linkage and Deduplication
Creators: name: Steorts, Rebecca C.
name: Hall, Rob
name: Fienberg, Stephen E.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: We propose an unsupervised approach for linking records across arbitrarily many files, while simultaneously detecting duplicate records within files. Our key innovation involves the representation of the pattern of links between records as a bipartite graph, in which records are directly linked to latent true individuals, and only indirectly linked to other records. This flexible representation of the linkage structure naturally allows us to estimate the attributes of the unique observable people in the population, calculate transitive linkage probabilities across records (and represent this visually), and propagate the uncertainty of record linkage into later analyses. Our method makes it particularly easy to integrate record linkage with post-processing procedures such as logistic regression, capture–recapture, etc. Our linkage structure lends itself to an efficient, linear-time, hybrid Markov chain Monte Carlo algorithm, which overcomes many obstacles encountered by previously record linkage approaches, despite the high-dimensional parameter space. We illustrate our method using longitudinal data from the National Long Term Care Survey and with data from the Italian Survey on Household and Wealth, where we assess the accuracy of our method and show it to be better in terms of error rates and empirical scalability than other approaches in the literature. Supplementary materials for this article are available online.
Phlogothamnus rugosus Li 2011
Creators: name: Hassan, Muhammad Asghar
name: Zhang, Jie
name: Xing, Jichun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Phlogothamnus
Phlogothamnus rugosus

description: Phlogothamnus rugosus Li, 2011
 Phlogothamnus rugosus Li, 2011 in Li, Dai & Xing, 2011: 183. Type locality: China (Guizhou). Holotype male (GUGC).
 Distribution: Oriental. China (Guizhou, Jiangsu) (Li et al. 2011; Yao et al. 2022).
description: Published as part of Hassan, Muhammad Asghar, Zhang, Jie & Xing, Jichun, 2024, Taxonomic notes on the leafhopper genus Phlogothamnus Ishihara (Hemiptera: Cicadellidae: Deltocephalinae), with description of a new species from China, pp. 289-295 in Zootaxa 5432 (2) on page 294, DOI: 10.11646/zootaxa.5432.2.8, http://zenodo.org/record/10898783