cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A non-invasive direct nose to brain drug delivery platform vs. invasive brain delivery approach: patient-centered care impact analysis
Creators: name: Kobo-Greenhut, Ayala
name: Frankenthal, Hilel
name: Darawsha, Aziz
name: Karasik, Avraham
name: Beja, Adit Zohar
name: Hur, Tamir Ben
name: Ekstein, Dana
name: Amir, Lisa
name: Shahaf, Daniel
name: Shlomo, Izhar Ben
name: Shichor, Iris
name: Frey, William H.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Current literature lacks structured methodologies for analyzing medical technologies’ impact from the patient-centered care perspective. This study introduces, applies and validates ‘Patient-Centered Care Impact Analysis’ (PCIA) as a method for identifying patient-centered care associated demands and expectations for a particular technology and assessing its compliance with these demands. PCIA involves five stages: (1) demand identification, (2) ranking demands’ impact magnitude, (3) scoring demand compliance (DC), (4) demand priority (DP) assignment based on impact magnitude and compliance, (5) generating a summative impact priority number (IPN). PCIA was performed as a comparative assessment of two central nervous system (CNS) drug-delivery platforms; SipNose, a novel noninvasive Direct-Nose-to-Brain (DNTB), vs. the standard-of-care invasive intrathecal/intracerebroventricular injection (Invasive I/I). Study participants included a ranking team (RT) without experience with the SipNose technology that based their scoring on experimental data; and a validation team (VT) experienced with the SipNose platform. All had experience with, or knowledge of, InvasiveI/I. Demand identification and impact magnitude were performed by one content and one assessment expert. Each participant assessed each technology’s DC. DP scores, IPN’s and IPN DNTB:InvasiveI/I ratios were generated for each technology, for each team, based on DC and summative DP scores, respectively. Both teams assigned DNTB higher DC scores, resulting in higher DNTB DP, IPN scores and DNTB:InvasiveI/I IPN ratios. Lack of difference between team assessments of DP and IPN ratio validate PCIA as an assessment tool capable of predicting patient-centered clinical care quality for a new technology. The significant differences between the platforms highlight SipNose’s patient-care centered advantages as an effective CNS drug-delivery platform.
Gaia Data Release 1: Catalogue validation
Creators: name: Arenou, F.
name: Luri, X.
name: Babusiaux, C.
name: Fabricius, C.
name: Helmi, A.
name: Robin, A. C.
name: Vallenari, A.
name: Blanco-Cuaresma, S.
name: Cantat-Gaudin, T.
name: Findeisen, K.
name: Reylé, C.
name: Ruiz-Dern, L.
name: Sordo, R.
name: Turon, C.
name: Walton, N. A.
name: Shih, I-C.
name: Antiche, E.
name: Barache, C.
name: Barros, M.
name: Breddels, M.
name: Carrasco, J. M.
name: Costigan, G.
name: Diakité, S.
name: Eyer, L.
name: Figueras, F.
name: Galluccio, L.
name: Heu, J.
name: Jordi, C.
name: Krone-Martins, A.
name: Lallement, R.
name: Lambert, S.
name: Leclerc, N.
name: Marrese, P. M.
name: Moitinho, A.
name: Mor, R.
name: Romero-Gómez, M.
name: Sartoretti, P.
name: Soria, S.
name: Soubiran, C.
name: Souchay, J.
name: Veljanoski, J.
name: Ziaeepour, H.
name: Giuffrida, G.
name: Pancino, E.
name: Bragaglia, A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Before the publication of the Gaia Catalogue, the contents of the first data release have undergone multiple dedicated validation tests. These tests aim at analysing in-depth the Catalogue content to detect anomalies, individual problems in specific objects or in overall statistical properties, either to filter them before the public release, or to describe the different caveats of the release for an optimal exploitation of the data. Dedicated methods using either Gaia internal data, external catalogues or models have been developed for the validation processes. They are testing normal stars as well as various populations like open or globular clusters, double stars, variable stars, quasars. Properties of coverage, accuracy and precision of the data are provided by the numerous tests presented here and jointly analysed to assess the data release content. This independent validation confirms the quality of the published data, Gaia DR1 being the most precise all-sky astrometric and photometric catalogue to-date. However, several limitations in terms of completeness, astrometric and photometric quality are identified and described. Figures describing the relevant properties of the release are shown and the testing activities carried out validating the user interfaces are also described. A particular emphasis is made on the statistical use of the data in scientific exploitation.
description: 34 pages, 52 figures, 3 tables. Submitted to A&A on Oct. 14 as part of the Gaia DR1 special issue, accepted with minor revisions on Dec. 19
Second Screen User Profiling and Multi-level Smart Recommendations in the context of Social TVs
Creators: name: Valsamis, Angelos
name: Psychas, Alexandros
name: Aisopos, Fotis
name: Menychtas, Andreas
name: Varvarigou, Theodora
Publisher: name: arXiv
Year: 2017
Subjects: subject: Multimedia (cs.MM)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: In the context of Social TV, the increasing popularity of first and second screen users, interacting and posting content online, illustrates new business opportunities and related technical challenges, in order to enrich user experience on such environments. SAM (Socializing Around Media) project uses Social Media-connected infrastructure to deal with the aforementioned challenges, providing intelligent user context management models and mechanisms capturing social patterns, to apply collaborative filtering techniques and personalized recommendations towards this direction. This paper presents the Context Management mechanism of SAM, running in a Social TV environment to provide smart recommendations for first and second screen content. Work presented is evaluated using real movie rating dataset found online, to validate the SAM's approach in terms of effectiveness as well as efficiency.
description: In: Wu TT., Gennari R., Huang YM., Xie H., Cao Y. (eds) Emerging Technologies for Education. SETE 2016
title: ADCO, Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Cart. 21 (G 125), 71 folios, f. 00038
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00038, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00038, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Cloud based flexibility management system: Flexibility Cloud, phase 1 - D8.1 INVADE H2020
Creators: name: Fisher, Mark
name: Spetaas, Jon E.
name: Ottesen, Stig Ø.
name: Lundby, Terje
Publisher: name: Zenodo
Year: 2018

description: In the INVADE project, a central delivery is the cloud-based Integrated INVADE platform, which will be used by the Flexibility Operator to manage flexibility from flexibility providers and offer this to flexibility customers. The first version of the Integrated INVADE platform will be delivered in June 2018 and implemented at pilots during the autumn 2018. The fundamental parts of the Integrated INVADE platform, namely the asset management, asset control and data repository, is presented in this delivery. It will be followed up with a second delivery, which will focus on the business intelligence in the Integrated INVADE platform. This delivery is due in June 2018.
Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
Creators: name: Murthy, Akula S. N.
name: Das, Sanket
name: Singh, Tejinder
name: Kim, Tae-Wan
name: Sepay, Nasim
name: Jeon, Seob
name: Im, Jungkyun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities. In an attempt to develop a new mitochondria-targeting vector, we synthesized sorbitol-based molecular transporters with multiple guanidines, measured their partition coefficients, compared their targeting efficiency using fluorescent images and Pearson's correlation coefficients, and studied cellular uptake mechanisms. To increase the targeting ability of these molecular transporters to mitochondria, alanine-naphthalene as a lipophilic group was attached to the molecular transporter, which improved translocation across cellular membranes and led to higher accumulation in mitochondria. The molecular transporter was able to form an ionic complex with antibiotics, resulting in low cell viability. These data demonstrate that the molecular transporter with a lipophilic group could be utilized as a potential drug delivery vector for treating mitochondrial dysfunction.
When artificial post-response outcomes did not modulate the Potentiation Effect of Grasping Behaviours
Creators: name: Dru, Vincent
name: Guerineau, Ronan
name: Brouillet Denis
name: Heurley, Loïc P.
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: Cognition and Perception

description: Seeing large (e.g., pears) or small objects (e.g., cherries) potentiates power and precision grip, respectively. According to the motor simulation account, this potentiation effect reflects an automatic access to object representation, including the grip usually associated with the object. Alternatively, this effect might be due to an overlap between magnitude codes used to represent both manipulable objects and response outcomes. In Experiment 1, participants saw objects usually grasped with a power or precision grip and had to mimic these gestures on a specific device. In the corresponding and non-corresponding conditions, each response generated low-pitch or high-pitch tone (i.e., a large vs. small perceptual outcome, respectively). In line with the ideomotor theories according to which voluntary actions are carried out due to the anticipation of their outcomes, each response generated a low-pitch or high-pitch tone. Response times were shorter when the object and the response were compatible than when they were not, independently of the magnitude of the artificial post-response outcome. Our results suggest that the potentiation effect could, under some circumstances, be immune to post-responses outcomes, which could be consistent with both motor simulation and magnitude coding accounts. To further disentangle these explanations, we conducted a second experiment with the device set horizontally to eliminate the grasping component of the responses. As in Heurley et al. (2020), the results revealed a potentiation-like effect, suggesting that the underlying process in our experiments could be better explained by the magnitude coding account.
title: Qualification et quantification des flux de la mine au lagon et de leurs impacts. Rapport synthétique des travaux
Creators: name: Allenbach, Michel
name: Bertand, Mélanie
name: Despinoy, Marc
name: Evrard, Olivier
name: Garcin, Manuel
name: Liébault, Frédéric
name: Navratil, Oldrich
name: Recking, Alain
name: Richard, Didier
name: Rouet, Isabelle
name: Sabinot, Catherine
name: Sellier, Virginie
name: Tessier, Bernadette
name: Thinon, Isabelle
name: Touraivane, T.
name: Worliczek, Élisabeth
Publisher: name: CNRT Nickel et son environnement
Year: 2020
Subjects: subject: FOS: Earth and related environmental sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Programme Immila. [Tome Nickel et Environnement]
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats
Creators: name: Soliman, Sara M.
name: Mosallam, Shaimaa
name: Mamdouh, Mohamed A.
name: Hussein, Mohammed Abdalla
name: El-Halim, Shady M. Abd
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Plant Biology

description: Cranberry extract (CBE) is a major source of the antioxidant polyphenolics but suffers from limited bioavailability. The goal of this research was to encapsulate the nutraceutical (CBE), into bile salt augmented liposomes (BSALs) as a promising oral delivery system to potentiate its hepatoprotective impact against dimethylnitrosamine (DMN) induced liver injury in rats. The inclusion of bile salt in the liposomal structure can enhance their stability within the gastrointestinal tract and promote CBE permeability. CBE loaded BSALs formulations were fabricated utilizing a (23) factorial design to explore the impact of phospholipid type (X1), phospholipid amount (X2), and sodium glycocholate (SGC) amount (X3) on BSALs properties, namely; entrapment efficiency percent, (EE%); vesicle size, (VS); polydispersity index; (PDI); zeta potential, (ZP); and release efficiency percent, (RE%). The optimum formulation (F1) exhibited spherical vesicles with EE% of 71.27 ± 0.32%, VS; 148.60 ± 6.46 nm, PDI; 0.38 ± 0.02, ZP; −18.27 ± 0.67 mV and RE%; 61.96 ± 1.07%. Compared to CBE solution, F1 had attenuated DMN-induced hepatic injury, as evidenced by the significant decrease in serum level of ALT, AST, ALP, MDA, and elevation of GSH level, as well as SOD and GPX activities. Furthermore, F1 exhibited an anti-inflammatory character by suppressing TNF-α, MCP-1, and IL-6, as well as downregulation of VEGF-C, STAT-3, and IFN-γ mRNA levels. This study verified that when CBE was integrated into BSALs, F1, its hepatoprotective effect was significantly potentiated to protect the liver against DMN-induced damage. Therefore, F1 could be deliberated as an antioxidant, antiproliferative, and antifibrotic therapy to slow down the progression of hepatic damage.
Repulsive interactions and their effects on the thermodynamics of hadron gas
Creators: name: Lo, Pok Man
name: Friman, Bengt
name: Marczenko, Michal
name: Redlich, Krzysztof
name: Sasaki, Chihiro
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compare two approaches in modeling repulsive interactions among hadrons: the excluded volume approximation and the S-matrix formalism. These are applied to study the thermodynamics of the $πN Δ$ system. It is shown that the introduction of an extraneous repulsion between pions and nucleons via the excluded volume approach, in addition to the interaction that generates the $Δ$-resonance, is incompatible with the analysis based on the physical phase shift of pion-nucleon scattering in the $P_{33}$ channel. This finding suggests that the repulsive force between hadrons is interaction-channel dependent and is hence unlikely to be captured by a single phenomenological parameter. The S-matrix approach employed here can be used, however, to provide useful estimates of the magnitude of the effective eigenvolume.
description: 6 pages, 2 figures, submitted to phys. rev. c
PREMIS in Rosetta - A Play in 3 Acts
Creators: name: Lindlar, Michelle
Publisher: name: Zenodo
Year: 2018
Subjects: digital preservation
preservation metadata
PREMIS

description: This is the preservation given as part of a nestor expert workshop on preservation metadata in Maintal, Germany on March 15th 2018. The presentation briefly describes TIB's preservation rationale and setup to give background to the implementation (Act 1). shows how the PREMIS semantic entities Object, Event, Agent and Right are implemented in the system and used by TIB (Act 2) and concludes with a brief outlook on shared community and vendor maintenance of a PREMIS implementation (Act 3).
Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer
Creators: name: Wang, Jing
name: Zhang, Yan
name: Zhang, GuangPeng
name: Xiang, Li
name: Pang, HaoWen
name: Xiong, Kang
name: Lu, Yun
name: Li, JianMei
name: Dai, Jie
name: Lin, Sheng
name: Fu, ShaoZhi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Chemotherapy is the primary treatment for advanced non-small-cell lung cancer (NSCLC). However, related dose-dependent toxicity limits its clinical use. Therefore, it is necessary to explore new strategies for improving the clinical outcomes while reducing the side effects of chemotherapy in the treatment of NSCLC. In this study, we designed and synthesized epidermal growth factor (EGF)-modified doxorubicin nanoparticles (EGF@DOX-NPs) that selectively targets the epidermal growth factor receptor (EGFR) overexpressed in lung tumor cells. When administered in combination with low-dose X-ray radiotherapy (RT), the NPs preferentially accumulated at the tumor site due to radiation-induced outburst of the local intra-tumoral blood vessels. Compared with DOX alone, EGF@DOX-NPs significantly decreased the viability and migration and enhanced the apoptosis rates of tumor cells in vitro. Also, the EGF@DOX-NPs significantly inhibited tumor growth in vivo, increasing the survival of the tumor-bearing mice without apparent systemic toxic effects through RT-induced aggregation. The tumor cell proliferation was greatly inhibited in the RT + EGF@DOX-NPs group. Contrarily, the apoptosis of tumor cells was significantly higher in this group. These results confirm the promising clinical application of radiotherapy in combination with EGF@DOX-NPs for lung cancer treatment.
Optical Spectra of Ultracool Dwarfs with the Southern African Large Telescope
Creators: name: Koen, C.
name: Miszalski, B.
name: Väisänen, P.
name: Koen, T.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: New spectra of 81 ultracool dwarfs (spectral types M7 and later) are discussed. Spectral classifications of 49 objects are available in the literature, while 32 objects are newly classified. The known spectral types were used to test an automated classification scheme, which relies primarily on template fitting, supplemented by matching of spectral indices calibrated against the template spectra. An attempt was made to quantify the uncertainty in the spectral types, which is generally better than two subclasses. Objects for which spectral types differ by more than one subclass from the literature classifications are discussed individually. Discrepancies between automated classifications based on respectively template fitting and spectral index matching, may be useful for flagging objects with unusual spectra. Aside from the 32 first-time classifications, alternative classifications are presented for 32 previously classified dwarfs. Very large (equivalent width greater than 130 Å) H$α$ flares are reported for the known ultracool dwarf binary 2MASS J15200224$-$4422419; curiously, the object does not appear to have quiescent emission lines. Non-zero equivalent width measurements are listed for a further 29 objects.
description: Accepted for publication in MNRAS. 33 pages, 12 figures, 6 tables
Cloud based flexibility management system: Flexibility Cloud, phase 2 - D8.2 INVADE H2020
Creators: name: Spetaas, Jon E.
name: Fisher, Mark
name: Eriksen, Susann K.
name: Minh Tran, Hoang
name: Priya Kotu, Lasya
name: Lundby, Terje
Publisher: name: Zenodo
Year: 2018

description: In the INVADE project, a central delivery is the cloud-based Integrated INVADE platform, which will be used by the Flexibility Operator to manage flexibility from flexibility providers and offer this to flexibility customers. The first version of the Integrated INVADE platform will be delivered in June 2018 and implemented at pilots during the autumn 2018. The fundamental parts of the Integrated INVADE platform, namely the asset management, asset control and data repository, was presented in D8.1. This second delivery will focus on the business intelligence in the Integrated INVADE platform covering Contract management, Meter values management, Events and external information, Calculator and scheduling, Predictions Management, Flexibility optimization management, Follow-up and reporting, and finally describe the Control signals management. The delivery focuses on the flexibility services offered to a prosumer; ToU optimization, kWmax control and Self-balancing. To support the three flexibility services listed above, each of the above-mentioned platform functionalities are needed. These can be seen as individual processes and the overall platform functionality consist of these processes and their linkage.
title: Clé de coffre à capucine (Inv. 2003.7.6941.2) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: clé

description: Des dizaines de clés ont été retrouvées à Bibracte  de formes variées. Une large gamme de serrures était disponible  certaines dotées de mécanismes sophistiqués à ressort et adaptées à divers usages : verrouillage de portes  de coffrets  voire de menottes et d entraves. Cette omniprésence témoigne d un souci de préserver ses biens.
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.
Creators: name: De Strooper, Bart
name: Karran, Eric
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Stem Cells
subject: Stem Cells
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Human Biology & Physiology
subject: Human Biology & Physiology
classificationCode: Model organisms
subject: Model organisms
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Cell Biology
subject: Cell Biology

description: Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal, i.e. slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be the optimal therapeutic modality for AD prevention, as we will discuss in the context of the earlier small molecules described as "γ-secretase modulators" (GSM). We review here the structure, function, and pathobiology of γ-secretases, with a focus on how mutations in presenilin genes result in early-onset AD. Significant progress has been made in generating compounds that act in a manner opposite to pathogenic presenilin mutations: they stabilize the proteinase-substrate complex, thereby increasing the processivity of substrate cleavage and altering the size spectrum of Aβ peptides produced. We propose the term "γ-secretase allosteric stabilizers" (GSAS) to distinguish these compounds from the rather heterogenous class of GSM. The GSAS represent, in theory, a precision medicine approach to the prevention of amyloid deposition, as they specifically target a discrete aspect in a complex cell biological signalling mechanism that initiates the pathological processes leading to Alzheimer's disease.
DEVELOPMENT OF ENGLISH COMMUNICATIVE COMPETENCE OF ENGINEERING STUDENTS
Creators: name: Kholmurodova E'zoza Xasanovna
Publisher: name: Zenodo
Year: 2024

description: Abstract: The article justifies the importance of learning a foreign language for engineering students. Concepts such as competence, professional competence, communication skills, and professional ability to communicate in a foreign language are explained. The characteristics of foreign language learning for students of universities of technology are also defined. Various practical classes used by foreign language teachers are described, and new pedagogical technologies are introduced that ensure the effective development of foreign language skills of technical students.

Keywords: qualification, communication skills, foreign language communication skills, professionally oriented literature.
Additional file 1: of Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children
Creators: name: Ubillos, Itziar
name: Ayestaran, Aintzane
name: Nhabomba, Augusto
name: Dosoo, David
name: Vidal, Marta
name: Jiménez, Alfons
name: Jairoce, Chenjerai
name: Sanz, Hèctor
name: Aguilar, Ruth
name: Williams, Nana
name: Díez-Padrisa, Núria
name: Mpina, Maximilian
name: Sorgho, Hermann
name: Agnandji, Selidji
name: Kariuki, Simon
name: Mordmüller, Benjamin
name: Daubenberger, Claudia
name: Asante, Kwaku
name: Owusu-Agyei, Seth
name: Sacarlal, Jahit
name: Aide, Pedro
name: Aponte, John
name: Dutta, Sheetij
name: Gyan, Ben
name: Campo, Joseph
name: Valim, Clarissa
name: Moncunill, Gemma
name: Dobaño, Carlota
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary methods (DOC 11140 kb)
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00491
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00491, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 2 of Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing
Creators: name: Gao, Manman
name: Guo, Peng
name: Liu, Xizhe
name: Zhang, Penghui
name: He, Zhongyuan
name: Wen, Liru
name: Liu, Shaoyu
name: Zhou, Zhiyu
name: Zhu, Weimin
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 2:
Comparison of different bonding techniques for efficient strain transfer using piezoelectric actuators
Creators: name: Ziss, Dorian
name: Martín-Sánchez, Javier
name: Lettner, Thomas
name: Halilovic, Alma
name: Trevisi, Giovanna
name: Trotta, Rinaldo
name: Rastelli, Armando
name: Stangl, Julian
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this paper strain transfer efficiencies from single crystalline piezoelectric lead magnesium niobate-lead titanate (PMN-PT) substrate to a GaAs semiconductor membrane bonded on top are investigated using state-of-the-art x-ray diffraction (XRD) techniques and finite-element-method (FEM) simulations. Two different bonding techniques are studied, namely gold-thermo-compression and polymer-based SU8 bonding. Our results show a much higher strain-transfer for the "soft" SU8 bonding in comparison to the "hard" bonding via gold-thermo-compression. A comparison between the XRD results and FEM simulations allows to explain this unexpected result with the presence of complex interface structures between the different layers.
description: 17 pages, 7 Figures, 1 Table
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment
Creators: name: Ebada, Heba M. K.
name: Nasra, Maha M. A.
name: Nassra, Rasha A.
name: Abdallah, Ossama Y.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology

description: Novel intra-articular nanoreservoirs were implemented employing different cartilage targeting approaches to improve cartilage bioavailability of a chondroprotective drug, cassic acid (CA), for effective amelioration of cartilage deterioration off-targeting CA gastrointestinal disorders. Herein, we compared active cartilage-targeting approach via chondroitin sulfate (CHS) functionalization versus passive targeting using positively charged nanoparticles to target negatively charged cartilage matrix. Firstly, CA integrated nanoreservoirs (CA-NRs) were fabricated based on ionic conjugation between CA and cationic hydrophobic surface modifier octadecylamine (ODA) and were further functionalized with CHS to develop CHS-CA-NRs. Confocal laser microscope was used to visualize the accumulation of nanoparticles into the cartilage tissue. Both targeting approaches promoted CA local cartilage availability and prolonged its residence time. Compared to passive targeted CA-NRs, active targeted CHS-CA-NRs showed higher fluorescence signals in proximity to and inside chondrocytes which lasted for up to 21 days. In MIA-osteoarthritic rats, CHS-CA-NRs showed superior antiosteoarthritic activity, exhibiting highest cartilage repair compared to CA-NRs. Additionally, CHS-CA-NRs significantly inhibited OA inflammatory cytokine, degradation enzyme and oxidative stress and improved cartilage matrix biosynthesis. Conclusively, CHS-CA-NRs improved OA repair showing a superior efficacy for articular cartilage targeting with CHS which could be a potential advance for OA therapy.
Limits on the anomalous speed of gravitational waves from binary pulsars
Creators: name: Velten, Hermano
name: Jiménez, Jose Beltrán
name: Piazza, Federico
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A large class of modified theories of gravity used as models for dark energy predict a propagation speed for gravitational waves which can differ from the speed of light. This difference of propagations speeds for photons and gravitons has an impact in the emission of gravitational waves by binary systems. Thus, we revisit the usual quadrupolar emission of binary system for an arbitrary propagation speed of gravitational waves and obtain the corresponding period decay formula. We then use timing data from the Hulse-Taylor binary pulsar and obtain that the speed of gravitational waves can only differ from the speed of light at the percentage level. This bound places tight constraints on dark energy models featuring an anomalous propagations speed for the gravitational waves.
description: 6 pages, 1 figure, Prepared for the IWARA2016 proceedings
SoMeASL Presentation at HDLS16 (2024)
Creators: name: Occhino, Corrine
name: Hochgesang, Julie A.
Publisher: name: OSF
Year: 2024
Subjects: American Sign Language (ASL)
SoMeASL
deaf
linguistics
phonetics
phonology
social media

description: Presentation slides and notes for "What happens when our articulators are outside of our mouths: Examination of phonological processes when active articulators are occupied" presented at HDLS 16 - November 2024 by Julie A. Hochgesang, Cem Barutcu, & Corrine Occhino
title: 02_1035
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity
Creators: name: Ji, Peng
name: Wang, Xianglong
name: Yin, Jiabing
name: Mou, Yi
name: Huang, Haiqin
name: Ren, Zhenkun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Space Science
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Breast cancer is prevalent and diverse with significantly high incidence and mortality rates. Curcumin (Cur), a polyphenol component of turmeric, has been widely recognized as having strong anti-breast cancer activity. However, its anti-cancer efficiency is largely impaired by some of its concomitant negative properties, including its poor solubility, low cellular uptake, and severe reported side effects. Hence, the necessity arises to develop a novel low-toxic and high-efficiency targeting drug delivery system (DDS). In this study, we developed a pH-sensitive tumor self-targeting DDS (Cur@HFn) based on self-assembled HFn loaded with Cur, in which Cur was encapsulated into HFn cavity by using a disassembly/reassembly strategy, and the Cur@HFn was characterized by ultraviolet–visible (UV–vis), dynamic light scattering (DLS), and transmission electron microscope (TEM). A variety of breast cancer cell models were built to evaluate cytotoxicity, apoptosis, targeting properties, and uptake mechanism of the Cur@HFn. The pharmacodynamics was also evaluated in tumor (4T1) bearing mice after intravenous injection. In vitro release experiments showed that Cur@HFn is pH sensitive and shows sustained drug release under slightly acidic conditions. Compared with Cur, Cur@HFn has stronger cytotoxicity, cellular uptake, and targeting performance. Our study supported that Cur@HFn has a higher in vivo therapeutic effect and lower systemic toxicity. The safety evaluation results indicated that Cur@HFn has no hematotoxicity, hepatotoxicity, and nephrotoxicity. The findings of the present study showed that the Cur@HFn has been successfully prepared and has potential application value in the treatment of breast cancer.
Improving Privacy and Security in Multi-Tenant Cloud ERP Systems
Creators: name: Djamal Ziani
name: Al-Muwayshir, Ruba
Publisher: name: figshare
Year: 2018
Subjects: subject: 80504 Ubiquitous Computing
subject: FOS: Computer and information sciences
subject: Distributed Computing

description: This paper discusses cloud ERP security challenges and their existing solutions. Initially, a set of definitions associated with ERP systems, cloud computing, and multi-tenancy, along with their respective challenges and issues regarding security and privacy, are provided. Next, a set of security challenges is listed, discussed, and mapped to the existing solutions to solve these problems. This thesis aims to build an effective approach to the cloud ERP security management model in terms of data storage, data virtualization, data isolation, and access security in cloud ERP. The following proposed techniques are used to improve the security for multi-tenant SaaS: database virtualization, implementation of data encryption and search functionality on databases and developed systems, distribution of data between tenant and ERP providers, secure application deployment in multi-tenant environments, implementation of the authentication and developed systems together as a two-factor authentication, and improved user access control for multi-tenant ERP clouds.
Analysis of scalar dissipation in terms of vorticity geometry in isotropic turbulence
Creators: name: Gonzalez, Michel
Publisher: name: arXiv
Year: 2016
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The mechanisms promoting scalar dissipation through scalar gradient production are scrutinized in terms of vorticity alignment with respect to strain principal axes. For that purpose, a stochastic Lagrangian model for the velocity gradient tensor and the scalar gradient vector is used. The model results show that the major part of scalar dissipation occurs for stretched vorticity, namely when the vorticity vector aligns with the extensional and intermediate strain eigenvectors. More specifically, it appears that the mean scalar dissipation is well represented by the sample defined by alignment with the extensional strain, while the most intense scalar dissipation is promoted by the set of events for which vorticity aligns with the intermediate strain. This difference is explained by rather subtle mechanisms involving the statistics of both the strain intensities and the scalar gradient alignment resulting from these special alignments of vorticity. The analysis allowing for the local flow structure confirms the latter scenario for both the strain-and rotation-dominated events. However, despite the prevailing role of strain in promoting scalar dissipation, the difference in the level of scalar dissipation when vorticity aligns with either the extensional or the intermediate strain mostly arises from rotation-dominated events.
title: Clé de coffre à capucine (Inv. 2003.7.6941.2)
Creators: name: Paris, Pascal
name: Tisserand, Nicolas
name: Chevrier, Sébastien
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: clé
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Ultra-Flat Galaxies Selected from RFGC Catalog. III. Star Formation Rate
Creators: name: Melnyk, O. V.
name: Karachentseva, V. E.
name: Karachentsev, I. D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We examine the star formation properties of galaxies with very thin disks selected from the Revised Flat Galaxy Catalog (RFGC). The sample contains 333 ultra-flat galaxies (UFG) at high Galactic latitudes, $|b|>10^{\circ}$, with a blue major angular diameter of $a\geq 1.2^{\prime}$, blue and red apparent axial ratios of $(a/b)_b > 10$, $(a/b)_r > 8.5$ and radial velocities within 10000~km s$^{-1}$. As a control sample for them we use a population of 722 more thick RFGC galaxies with $(a/b)_b > 7$, situated in the same volume. The UFG distribution over the sky indicates them as a population of quite isolated galaxies. We found that the specific star formation rate, sSFR FUV, determined via the FUV GALEX flux, increases steadily from the early type to late type disks for both the UFG and RFGC-UFG samples, showing no significant mutual difference within each morphological type T. The population of UFG disks has the average H,I-mass-to-stellar-mass ratio by $(0.25\pm0.03)$ dex higher than that of RFGC--UFG galaxies. Being compared with arbitrary orientated disks of the same type, the ultra-flat edge-on galaxies reveal that their total H,I mass is hidden by self-absorption on the average by approximately 0.20 dex. We demonstrate that using the robust stellar mass estimate via $\langle B-K \rangle$-color and galaxy type T for the thin disks, together with a nowaday accounting for internal extinction, yields their sSFR quantities definitely lying below the limit of $-9.4$ dex,(yr$^{-1}$). The collected observational data on UFG disks imply that their average star formation rate in the past has been approximately three times the current SFR. The UFG galaxies have also sufficient amount of gas to support their observed SFR over the following nearly 9 Gyrs.
description: 22 pages, 10 figures, 2 tables, accepted in Astrophysical Bulletin
Variety awareness, nutrition knowledge and adoption of nutritionally enhanced crop varieties: Evidence from Kenya
Creators: name: Muthini, Davis Nguthi
name: Nzuma, Jonathan Makau
name: Nyikal, Rose Adhiambo
name: Muthini, Davis Nguthi
name: Nzuma, Jonathan Makau
name: Nyikal, Rose Adhiambo
Publisher: name: Unknown
Year: 2019
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: biofortification
subject: adoption
subject: nutrition knowledge
subject: variety awareness
subject: nutrition

description: This paper evaluates the impact of variety awareness and nutrition knowledge on the adoption of biofortified crop varieties using a sample of 661 households from Kisii and Nyamira counties in Kenya. The study employs the average treatment effect (ATE) framework to control for information on the KK15 bean variety and knowledge of its nutritional attributes among small-scale farmers. The results show that farmers who had knowledge of the nutritional attributes of KK15 beans were more likely to adopt relative to those who were only aware of the variety. A nutrition attribute knowledge gap of 8% was estimated, which represents the potential adoption loss due to a lack of knowledge of the nutritional benefits. Adoption of biofortified crops can therefore be improved by disseminating information on the varieties and their nutritional attributes. This can be achieved by entrenching nutrition information in extension packages disseminated to farmers.
Additional file 7: Table S3. of A novel genomic signature predicting FDG uptake in diverse metastatic tumors
Creators: name: Crespo-Jara, Aurora
name: Redal-PeĂąa, Maria
name: Martinez-Navarro, Elena
name: Sureda, Manuel
name: Fernandez-Morejon, Francisco
name: Garcia-Cases, Francisco
name: Manzano, Ramon
name: Brugarolas, Antonio
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Plant Biology
subject: 60506 Virology

description: Characteristics of the patients in the validation set along with their measured and predicted (SUVPLS) SUV values. (DOCX 13Â kb)