cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
De-black-boxing health AI: demonstrating reproducible machine learning computable phenotypes using the N3C-RECOVER Long COVID model in the All of Us data repository
Creators: name: Kerchberger, V Eric
name: Haendel, Melissa
name: Wei, Wei-Qi
name: Lunt, Chris
name: Harris, Paul A
name: Pfaff, Emily R
name: Gangireddy, Srushti
name: Weiner, Mark
name: Moffitt, Richard A
name: Chute, Christopher G
name: Basford, Melissa
name: Girvin, Andrew T
name: N3C and RECOVER Consortia
name: Crosskey, Miles
name: Master, Hiral
Publisher: name: Oxford University Press
Year: 2023

description: Machine learning (ML)-driven computable phenotypes are among the most challenging to share and reproduce. Despite this difficulty, the urgent public health considerations around Long COVID make it especially important to ensure the rigor and reproducibility of Long COVID phenotyping algorithms such that they can be made available to a broad audience of researchers. As part of the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative, researchers with the National COVID Cohort Collaborative (N3C) devised and trained an ML-based phenotype to identify patients highly probable to have Long COVID. Supported by RECOVER, N3C and NIH’s All of Us study partnered to reproduce the output of N3C’s trained model in the All of Us data enclave, demonstrating model extensibility in multiple environments. This case study in ML-based phenotype reuse illustrates how open-source software best practices and cross-site collaboration can de-black-box phenotyping algorithms, prevent unnecessary rework, and promote open science in informatics.
Roles of Innovation in Education Delivery
Creators: name: Joyner, Pamela U.
name: Beck, Diane E.
name: Riffee, William H.
name: Green, Charles
name: Blouin, Robert A.
name: Persky, Adam M.
name: Pollack, Gary M.
name: Robinson, Evan T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: This paper reviews trends in higher education, characterizing both the current learning environments in pharmacy education as well as a vision for future learning environments, and outlines a strategy for successful implementation of innovations in educational delivery. The following 3 areas of focus are addressed: (1) rejecting the use of the majority of classroom time for the simple transmission of factual information to students; (2) challenging students to think critically, communicate lucidly, and synthesize broadly in order to solve problems; and (3) adopting a philosophy of “evidence-based education” as a core construct of instructional innovation and reform.
Probing the scotogenic model with lepton flavor violating processes
Creators: name: Vicente, Avelino
name: Yaguna, Carlos E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the impact that future lepton flavor violating experiments will have on the viable parameter space of the scotogenic model. Within this model, the dark matter particle is assumed to be the lightest singlet fermion and two cases are considered depending on how its relic density is obtained: via self-annihilations or via coannihilations with the scalars. For each case, a scan over the parameter space of the model is used to obtain a large sample of viable points, which we subsequently analyze. We find that future lepton flavor violating experiments, in particular those searching for $μ\to 3e$ and $μ$-$e$ conversion in nuclei, will probe the parameter space of the scotogenic model in a significant way. They may exclude a large fraction of the models where the dark matter density is determined by coannihilations, and could rule out all the models where it is determined by annihilations.
description: 32 pages v2: Minor changes to figures and text. Matches published version
Sozial-emotionale Kompetenzen in offenen Unterrichtsformen. Effekte auf sozial-emotionale Kompetenzen von offenen Unterrichtsformen mit den Grundmerkmalen der Freiarbeit
Creators: name: Arnold, David
Publisher: name: Zenodo
Year: 2023
Subjects: Sonderpädagogik
Masterarbeit
sozial-emotionale Kompetenz
offener Unterricht

description: Diese Arbeit untersucht die Effekte, die offene Unterrichtsformen auf die sozialemotionalen Kompetenzen von Schülerinnen und Schüler hat. Dazu werden im ersten Teil der Arbeit die Grundmerkmale der Freiarbeit aus verschiedenen Quellen der Literatur herausgearbeitet und schlussendlich definiert. Anschliessend werden verschiedene Formen und Konzepte von offenem Unterricht untersucht und auf ihre Passung bezüglich den Grundmerkmalen der Freiarbeit überprüft. Im zweiten Teil der Arbeit werden empirische und quantitative Studien, die sich mit diesem Thema beschäftigen, ausgewertet und beschrieben. Daraus wird geschlossen, dass offene Unterrichtsformen einen positiven Effekt auf die sozial-emotionalen Kompetenzen der Schülerinnen und Schüler hat. Die Datenlage ist allerdings noch dünn und für ein klareres Bild braucht es mehr Forschungsarbeiten in diesem Feld.
A new quark-hadron hybrid equation of state for astrophysics - I. High-mass twin compact stars
Creators: name: Benic, Sanjin
name: Blaschke, David
name: Alvarez-Castillo, David E.
name: Fischer, Tobias
name: Typel, Stefan
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Aims: We present a new microscopic hadron-quark hybrid equation of state model for astrophysical applications, from which compact hybrid star configurations are constructed. These are composed of a quark core and a hadronic shell with a first-order phase transition at their interface. The resulting mass-radius relations are in accordance with the latest astrophysical constraints. Methods: The quark matter description is based on a quantum chromodynamics (QCD) motivated chiral approach with higher-order quark interactions in the Dirac scalar and vector coupling channels. For hadronic matter we select a relativistic mean-field equation of state with density-dependent couplings. Since the nucleons are treated in the quasi-particle framework, an excluded volume correction has been included for the nuclear equation of state at suprasaturation density which takes into account the finite size of the nucleons. Results: These novel aspects, excluded volume in the hadronic phase and the higher-order repulsive interactions in the quark phase, lead to a strong first-order phase transition with large latent heat, i.e. the energy-density jump at the phase transition, which fulfils a criterion for a disconnected third-family branch of compact stars in the mass-radius relationship. These twin stars appear at high masses ($\sim$ 2 M$_\odot$) that are relevant for current observations of high-mass pulsars. Conclusions: This analysis offers a unique possibility by radius observations of compact stars to probe the QCD phase diagram at zero temperature and large chemical potential and even to support the existence of a critical point in the QCD phase diagram.
description: Accepted for publication in Astron. & Astrophys
Additional file 2: of Facilitators, best practices and barriers to integrating family planning data in Ugandaâ  s health management information system
Creators: name: Wandera, Stephen
name: Kwagala, Betty
name: Nankinga, Olivia
name: Ndugga, Patricia
name: Kabagenyi, Allen
name: Bridgit Adamou
name: Kachero, Benjamin
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Multi-stakeholder (MSD) Workshop Guide. (DOCX 15 kb)
Decision-Making about COVID-19 Vaccines among Health Care Workers and Their Adolescent Children
Creators: name: Choi K.
name: Bronstein D.
name: Chang J.
name: Delgado J.R.
name: Macias M.
name: Munoz-Plaza C.
name: Lewin B.
name: Mansfield L.N.
name: Bruxvoort K.
Publisher: name: SAGE Publications Inc.
Year: 2023

description: Health care workers promote COVID-19 vaccination for adolescent patients, and as parents, may influence their own children to get vaccinated. We conducted virtual, semi-structured qualitative interviews with vaccinated health care workers and their adolescent children to explore their decision-making process for COVID-19 vaccination. In total, 21 health care workers (physicians, nurses, and medical staff) and their adolescent children (N = 17) participated in interviews. The following three themes described parent-adolescent decision-making for COVID-19 vaccination: (1) family anticipation and hesitation about COVID-19 vaccine approval; (2) parents’ or adolescents’ choice: the decision maker for adolescent COVID-19 vaccination; and (3) leveraging one’s vaccination status to encourage others to get vaccinated. Nurses encouraged adolescent autonomy in decisions for COVID-19 vaccination while physicians viewed vaccination as the parent’s decision. Health care workers and their adolescent children used role-modeling to motivate unvaccinated peers and may model their decision-making process for adolescent COVID-19 vaccination with their own children to support their patients’ and parents’ vaccine decisions.
Succession Planning in US Pharmacy Schools
Creators: name: Green, James S.
name: Colbert, James
name: Van Amburgh, Jenny
name: Zatopek, Shara L.
name: Surratt, Christopher K.
name: Gallucci, Randle M.
name: Blouin, Robert A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The deans, associate and assistant deans, and department chairs of a college or school of pharmacy retain historic memories of the institution and share the responsibility for day-to-day operation, sustainability, and future planning. Between the anticipated retirement of baby boomers who are senior administrative faculty members and the steady increase in number of colleges and schools of pharmacy, the academy is facing a shortage of qualified successors. Succession planning involves planning for the effective transition of personnel in leadership positions within an organization. This paper describes the subject of succession planning at a sample population of AACP institutions by obtaining perspectives on the subject from the deans of these institutions via standardized interview instruments. The instruments were utilized with 15 deans; all interview data were blinded and analyzed using analyst triangulation. The majority of deans responded that some level of succession planning was desirable and even necessary; however, none claimed to have a formal succession planning structure in place at his or her home institution. Although widely accepted and well-recognized in the corporate and military sectors, succession planning within pharmacy schools and colleges is neither universally documented nor implemented. Differences exist within the administrative structure of these non-academic and academic institutions that may preclude a uniform succession planning format. While the evidence presented suggests that succession planning is needed within the academy, a concerted effort must be made towards implementing its practice.
Design and approval of the nutritional warnings’ policy in Peru: Milestones, key stakeholders, and policy drivers for its approval
Creators: name: Taillie, Lindsey Smith
name: Diez-Canseco, Francisco
name: Carpentier, Francesca R. Dillman
name: Cavero, Victoria
name: Miranda, J. Jaime
name: Cano, Juan Alvarez
name: Saavedra-Garcia, Lorena
Publisher: name: Public Library of Science
Year: 2023

description: Nutritional warnings are used as a public health strategy to address obesity. Peru approved in 2013 and implemented in 2019 a law requiring nutritional warnings on the marketing and packaging of processed foods high in sugar, sodium, saturated fat, and containing trans-fat. The complexity behind the design and approval of these policies over six years provides unique learnings, that inform the obesity prevention context, especially when proposed policies face strong opposition from powerful stakeholders. Our study aims to describe the milestones and key stakeholders’ roles and stances during the nutritional warnings policy design in Peru, and to identify and analyze the main drivers of policy change that explain its approval. In 2021, interviews were conducted with 25 key informants closely involved in its design. Interviews were analyzed using the Kaleidoscope Model as a theoretical framework. Relevant policy documents and news were also analyzed. Milestones for this policy included the approval of the Law, Regulation, and Manual. Policy supporters were mainly from Congress, civil society advocates, and Health Ministers. Opponents came from Congress, ministries linked to the economic sector, the food industry, and media. Across the years, warnings evolved from a single text, to traffic lights, to the approved black octagons. Main challenges included the strong opposition of powerful stakeholders, the lack of agreement for defining the appropriate evidence supporting nutritional warning parameters and design, and the political instability of the country. Based on the Kaleidoscope Model, the policy successfully targeted a relevant problem (unhealthy eating decisions) and had powerful advocates who effectively used focusing events to reposition the warnings in the policy agenda across the years. Negotiations weakened the policy but led to its approval. Importantly, government veto players were mostly in favor of the policy, which enabled its final approval despite the strong opposition.
The Status of PhD Education in Economic, Social, and Administrative Sciences Between 2005 and 2008
Creators: name: Blalock, Susan J.
name: Farley, Joel F.
name: Wang, Chi-Chuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To describe the funding, education, enrollment, and graduation patterns from economic, social, and administrative sciences PhD programs in colleges and schools of pharmacy in the United States.
Additional file 1: of A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
Creators: name: ServiĂ, Luis
name: Mariona JovĂŠ
name: Sol, Joaquim
name: Pamplona, Reinald
name: Mariona Badia
name: Montserrat, Neus
name: Portero-Otin, Manuel
name: Trujillano, Javier
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Differential metabolites according mortality (full list). Figure S1. Clinical specificity for metabolomics signature. A. PLS-DA analyses shows that metabolome is able to discriminate between those patients who survive and those patients who do not survive. Although the metabolomic profile of survived patients is homogenous, one of the non-surviving patients had a specific metabolomic profile (black arrow). B. Heatmap hierarchical clustering analyses using the 25 metabolites with the lowest p value (T-Student test) confirms that one patient has a specific metabolomic profile (black arrow). PLS-DA cross-validation details (4 components): Accuracy: 0.91, R2: 0.96, Q2: -0.141. The negative value of Q2 means that the model is not all predictive or is overfitted, probably because the low number of not surviving patients. (DOCX 239 kb)
Attachment PCR
Creators: name: Acosta, Kenneth
Publisher: name: figshare
Year: 2023
Subjects: Microbial ecology
Plant biology not elsewhere classified
Microbiology not elsewhere classified

description: The following is a PCR protocol for detecting bacteria associated with duckweed. This PCR protocol uses 2 primer sets: 1) primers from ribosomal intergenic spacer analysis (RISA) to amplify bacteria DNA and 2) primers complementary to the single-copy, plant-specific LEAFY gene to amplify DNA from Lemna minor (LmLFY) or Spirodela polyrhiza (SpLFY). By using both primer sets duckweed-associated bacteria can be detected.
title: Изменения территориально – поселенческой структуры на границе Ярославского и Романовского уездов в конце XV – начале XVI века
Creators: name: Гожалимова, О.
name: Иванов, Л.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье рассматривается территория правого и левого берега Волги в период противостояния великого князя московского Ивана III и князя Андрея Большого Угличского. Примером борьбы служит основание Рыбной и Борисоглебской слобод напротив Усть-Шексны и Романова. На основании письменных источников и археологических исследований очевидна связь организации слобод с экономическим противостоянием князей. Главным объектом противостояния были рыбные ловли, которые после ликвидации удела угличского князя перешли под контроль Ивана III. Организация добычи осетровых на езах требует комплекса ресурсов – мест лова, участков леса для сооружения езов, населения. После присоединения угличского удела к великокняжескому московскому, управление таким комплексом осталось на левом берегу в Романове, о чем свидетельствует документ 1527/28 гг. из дел Тайного приказа и отнесение Рыбной и Борисоглебской слобод к Пошехонью в документах 1563 и 1572 гг.
Notes on quantum weighted projective spaces and multidimensional teardrops
Creators: name: Brzeziński, Tomasz
name: Fairfax, Simon A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 58B32, 58B34

description: It is shown that the coordinate algebra of the quantum $2n+1$-dimensional lens space $\mathcal{O}(L^{2n+1}_q(\prod_{i=0}^n m_i; m_0,\ldots, m_n))$ is a principal $\mathbb{Z}$-comodule algebra or the coordinate algebra of a circle principal bundle over the weighted quantum projective space $\mathbb{WP}^n_q(m_0,\ldots, m_n)$. Furthermore, the weighted $U(1)$-action or the $\mathbb{CZ}$-coaction on the quantum odd dimensional sphere algebra $\mathcal{O}(S^{2n+1}_q)$ that defines $\mathbb{WP}^n_q(1,m_1,\ldots, m_n)$ is free or principal. Analogous results are proven for quantum real weighted projective spaces $\mathbb{RP}^{2n}_q(m_0,\ldots, m_n)$. The $K$-groups of $\mathbb{WP}^n_q(1,\ldots, 1, m)$ and $\mathbb{RP}^{2n}_q(1,\ldots, 1,m)$ and the $K_1$-group of $L^{2n+1}_q(N; m_0,\ldots, m_n)$ are computed
description: 14 pages; v2 minor revisions
HARBIY XIZMATCHI SPORTCHILARNING MUVAFFAQIYATGA ERISHISH MOTIVATSIYASINI SHAKLLANTIRISH
Creators: name: Alimardonov, Z.Sh.
name: Jalolov, B.
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada harbiy xizmatchi sportchilarning maksimal faolligini saqlashga, yuqori va barqaror natijalarga olib keladigan sharoitlarni yaratishga, muvaffaqiyatga erishish motivatsiyasini shakllantirishga, jamoada shakllangan sport an'analari sportchini hamma joyda va har doim o'z Vatani va shu bilan birga, jamoasi sharafini himoya qilishga, mas'uliyat hissini oshirishga va irodali fazilatlarni rivojlantirishga qaratilgan. Shuningdek, harbiy xizmatchi sportchilarning muvaffaqiyatga erishish motivatsiyasini shakllantirish bo'yicha amaliy takliflar bilan yakunlanadi.
title: Товарный отпуск «за свицкой рубеж» по данным таможенной книги Великого Новгорода 1677/78 г.
Creators: name: Раздорский, А.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье на основе сведений, содержащихся в таможенной книге Великого Новгорода 1677/78 г. проанализирован ассортимент, стоимость и объемы товарных партий, отправленных из Великого Новгорода и через таможенную заставу в устье реки Сясь в шведские владения. Рассмотрены сезонные колебания в динамике товарных поставок, географический и социальный состав торговцев. Описан зафиксированный в таможенной книге случай отправки в Швецию товарной партии контрабандой.
Editorial: Live cell imaging: Cell and developmental research bridging education, optical engineering, industry, software, shared facilities
Creators: name: Itano, Michelle S.
name: Kumar, Abhishek
name: Maddox, Paul S.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Optical imaging is one of the original technological pillars of biomedical research, spanning centuries of discovery. Drive for biological understanding has fueled significant progress in imaging tool development, ranging from illumination sources, detectors, and mechanical stages, to novel optical components and analysis strategies. The number and variety of optical imaging tools is now so vast that in some cases cutting-edge technologies require specialized training across a wide set of skills. Considering the exponential growth in imaging tools, fruitful and conducive partnerships between academic researchers, commercial vendors, and instrument facilitators, such as core facility managers and staff, are more important than ever.
Türkischer Islam - eine Herausforderung für Europa?
Creators: name: Şen, Faruk
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 20 Nr. 6 (1991): Internationale katholische Zeitschrift Communio, Band 20, Heft 6
Video Teleconferencing in the Compounding Laboratory Component of a Dual-Campus Doctor of Pharmacy Program
Creators: name: Robertson, Jennifer L.
name: Shrewsbury, Robert P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Objectives. To design, implement, and assess the effectiveness of using a live video teleconferencing system to connect the main campus and a satellite campus during laboratory compounding exercises in a doctor of pharmacy (PharmD) program.
Non-Abelian (Hyperscaling Violating) Lifshitz Black Holes in General Dimensions
Creators: name: Feng, Xing-Hui
name: Geng, Wei-Jian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider Einstein gravities coupled to a cosmological constant and multiple $SU(2)$ Yang-Mills fields in general dimensions and find that the theories admit colored Lifshitz solutions with dynamic exponents $z>1$. We also introduce a Maxwell field and construct exact electric charged black holes that asymptote to the $z=D-1$ colored Lifshitz spacetimes and analyse their thermodynamical first law. Furthermore, we introduce a dilaton to the system and construct Lifshitz spacetimes with hyperscaling violations. After turning on the Maxwell field, we obtain a class of hyperscaling violating Lifshitz black holes when $θ=\frac{2}{D-2}[z-(D-1)]$.
description: Latex, 12 pages, a published version in PLB
A Spanish Language Module in a First-Year Pharmaceutical Care Laboratory Course
Creators: name: Scolaro, Kelly L.
name: Dinkins, Melissa M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Objective. To assess the impact of incorporating Spanish language lectures and activities in a required Pharmaceutical Care Laboratory course on first-year doctor of pharmacy (PharmD) students’ perceptions of and comfort level with Spanish-speaking patients and basic knowledge of Spanish pharmacy terms.
title: Essays in household finance and innovation
Creators: name: Matcham, William Oliver
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2023

description: This thesis consists of two essays on household finance and one essay on innovation. Chapter 1 examines descriptively how UK credit card lenders set credit limits and interest rates for customers. First, I summarize the literature on credit card regulation and lenders’ choices of credit limits and interest rates. Second, I detail the relevant credit card regulation, focusing on how UK credit card lenders are required to advertize a “representative” interest rate for every credit card product they offer. Third, I describe my credit card dataset together with basic summary statistics. Finally, I offer a set of descriptive findings. My main results describe the limited variation in interest rates within credit card products relative to substantial variation in credit limits. In Chapter 2, I build on Chapter 1 by presenting and estimating an economic model of the UK credit card market. The modeling novelty is the link between individuals’ credit limits and lenders’ predictions of customers’ risk. With the estimated model, I examine a counterfactual scenario in which credit card lenders are subject to no costs and constraints in individualizing interest rates and credit limits, which the existing environment precludes. In this case, credit card lenders’ profits increase, consistent with lenders facing costs and constraints that discourage them from individualizing interest rates. In Chapter 3, we develop a dynamic structural model of patent screening incorporating incentives, intrinsic motivation, and multi-round negotiation. We use detailed data on examiner decisions and employ natural language processing to create a new measure of patent distance that enables us to study strategic decisions by applicants and examiners. We find that patent screening is moderately effective, given the existing standards for patentability. Examiners exhibit substantial intrinsic motivation that significantly improves the effectiveness of screening. A reform that limits negotiation rounds strongly increases screening quality. We quantify the annual net social costs of patent screening at $25.5bn, equivalent to 6.5% of U.S. private sector R&D.
Wer sind "wir" - wer ist "der Islam"?
Creators: name: Martini, Carlo Maria
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 20 Nr. 6 (1991): Internationale katholische Zeitschrift Communio, Band 20, Heft 6
Addressing Rural Health Disparities Through Pharmacy Curricula
Creators: name: Joyner, Pamela U.
name: Blouin, Robert A.
name: Thrasher, Kim A.
name: O’Connor, Shanna K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Approximately 75% of the United States is rural.1 While 20% of the US population lives outside of urban areas, only 9% of physicians and 12% of pharmacists practice in rural areas.2,3 This lack of access to primary care is compounded by the significant need for primary care by citizens in rural areas. More than 1 in 3 adults living in rural America is in poor to fair health, with nearly half having at least 1 major chronic illness.4 Individuals in rural areas have higher rates of smoking as well as obesity, diabetes, and other chronic diseases.5 In its 2005 report on rural health care, the Institute of Medicine asserted that many of the challenges faced by those living in rural areas can be attributed to the lack of access to basic health care services. Furthermore, this report described 5 strategies to address the lack of care in rural areas, and 1 strategy was to increase the supply of primary care health professionals in rural areas through improved education and training.4 Although the report did not specify types of providers, specially trained pharmacists may be able to address the health care disparities found in rural areas.
Assessment and Recommendations of Compounding Education in AACP Member Institutions
Creators: name: Nagel, Karen
name: Birnie, Christine
name: Shrewsbury, Robert
name: Ray, Dipan
name: Athay Adams, Jennifer
name: Scolaro, Kelly
name: Augustine, Sam
name: Ruble, James
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In August 2009, the American Association of Colleges of Pharmacy (AACP) Council of Sections established a Task Force to assess the current status of compounding education at its member institutions and to provide recommendations for future direction. The Task Force conducted a survey in late June 2010 of faculty members enrolled in the AACP Pharmaceutics and Pharmacy Practice sections to gain qualitative information of the current state of compounding education. The survey results were then organized around eight curricular topics for which the Task Force members provided interpretations and recommendations. A final report was sent to the AACP Council of Sections on February 15, 2011. This publication provides the information contained in that final report to the professional community.
Additional file 2: of Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue
Creators: name: Brodhagen, Johanna
name: Weikard, Rosemarie
name: Thom, Ulrike
name: Heimes, Annika
name: G체nther, Juliane
name: Hadlich, Frieder
name: Zerbe, Holm
name: Petzl, Wolfgang
name: Meyerholz, Marie
name: Hoedemaker, Martina
name: Hans-Joachim Schuberth
name: Engelmann, Susanne
name: K체hn, Christa
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Correlation plot of gene expression level (in log10 FPKM) between depleted and non-depleted RNA samples within E. coli challenged and non-challenged udder samples of each cow investigated. 0, A, and B represent the non-depleted or the depleted RNA samples (protocol variant A and B), respectively. (PDF 1551 kb)
Editorial: Vision zero: the safe system approach and traffic safety culture
Creators: name: Ward, Nicholas John
name: Baldwin, Shelly
name: Kumfer, Wesley
Publisher: name: Frontiers Media S.A.
Year: 2023

description: According to the World Health Organization, in 2018, traffic crashes killed over 1.35 million people (WHO, 2018). While some nations have seen declining trends in traffic fatalities post-COVID-19, for many nations, especially the United States, traffic fatalities continue to grow at an alarming rate. This rise is especially problematic for the most vulnerable, as pedestrians and bicyclists continue to be killed at disproportionate rates in many countries (ITF, 2022). Thus, for much of the world, a new traffic safety management paradigm is needed.
Effects of COVID-19 vaccination and previous SARS-CoV-2 infection on omicron infection and severe outcomes in children under 12 years of age in the USA: an observational cohort study
Creators: name: Lin, Dan-Yu
name: Wheeler, Bradford
name: Zeng, Donglin
name: Gu, Yu
name: Sunny, Shadia K.
name: Xu, Yangjianchen
name: Young, Hayley
name: Moore, Zack
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Background Data on the protection conferred by COVID-19 vaccination and previous SARS-CoV-2 infection against omicron (B.1.1.529) infection in young children are scarce. We aimed to estimate the time-varying effects of primary and booster COVID-19 vaccination and previous SARS-CoV-2 infection on subsequent omicron infection and severe illness (hospital admission or death) in children younger than 12 years of age. Methods In this observational cohort study, we obtained individual-level records on vaccination with the BNT162b2 and mRNA-1273 vaccines and clinical outcomes from the North Carolina COVID-19 Surveillance System and the COVID-19 Vaccine Management System for 1 368 721 North Carolina residents aged 11 years or younger from Oct 29, 2021 (Oct 29, 2021 for children aged 5–11 years and June 17, 2022 for children aged 0–4 years), to Jan 6, 2023. We used Cox regression to estimate the time-varying effects of primary and booster vaccination and previous infection on the risks of omicron infection, hospital admission, and death. Findings For children 5–11 years of age, the effectiveness of primary vaccination against infection, compared with being unvaccinated, was 59·9% (95% CI 58·5–61·2) at 1 month, 33·7% (32·6–34·8) at 4 months, and 14·9% (95% CI 12·3–17·5) at 10 months after the first dose. Compared with primary vaccination only, the effectiveness of a monovalent booster dose after 1 month was 24·4% (14·4–33·2) and that of a bivalent booster dose was 76·7% (45·7–90·0). The effectiveness of omicron infection against reinfection was 79·9% (78·8–80·9) after 3 months and 53·9% (52·3–55·5) after 6 months. For children 0–4 years of age, the effectiveness of primary vaccination against infection, compared with being unvaccinated, was 63·8% (57·0–69·5) at 2 months and 58·1% (48·3–66·1) at 5 months after the first dose, and the effectiveness of omicron infection against reinfection was 77·3% (75·9–78·6) after 3 months and 64·7% (63·3–66·1) after 6 months. For both age groups, vaccination and previous infection had better effectiveness against severe illness as measured by hospital admission or death as a composite endpoint than against infection. Interpretation The BNT162b2 and mRNA-1273 vaccines were effective against omicron infection and severe outcomes in children younger than 12 years, although the effectiveness decreased over time. Bivalent boosters were more effective than monovalent boosters. Immunity acquired via omicron infection was high and waned gradually over time. These findings can be used to develop effective prevention strategies against COVID-19 in children younger than 12 years.
Prospective Student Pharmacist Interest in a Rural Pharmacy Curriculum
Creators: name: Reichard, Jeffrey S.
name: Joyner, Pamela U.
name: O’Connor, Shanna K.
name: Thrasher, Kim A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Objective. To determine prospective student pharmacists’ interest in a rural pharmacy health curriculum.
Additional file 3: of Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue
Creators: name: Brodhagen, Johanna
name: Weikard, Rosemarie
name: Thom, Ulrike
name: Heimes, Annika
name: G체nther, Juliane
name: Hadlich, Frieder
name: Zerbe, Holm
name: Petzl, Wolfgang
name: Meyerholz, Marie
name: Hoedemaker, Martina
name: Hans-Joachim Schuberth
name: Engelmann, Susanne
name: K체hn, Christa
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Distribution of gene expression level (FPKM) for the depleted and non-depleted RNA samples from non-challenged udder samples. 0, A, and B represent the non-depleted or the depleted RNA samples (protocol variant A and B), respectively. (PDF 283 kb)
SURESOFT: Towards Sustainable Research Software
Creators: name: Linxweiler, Jan
Publisher: name: Zenodo
Year: 2022
Subjects: RSE, Software Development, FAIR4RS, FAIR

description: The research work of many scientists today includes the development and writing of research software. Thus, this software increasingly determines the scientific progress of many research disciplines. The goal of the SURESOFT project at the TU Braunschweig is therefore to support scientists in the development of scientific software and to contribute to the FAIRness of the software.
MULOQOTDA RETSEPTIV VA PRODUKTIV KO'NIKMALARNI SHAKLLANTIRUVCHI INTERFAOL MASHQLAR AHAMIYATI
Creators: name: Sattorova, Feruza
Publisher: name: Zenodo
Year: 2023

description: Interaktiv sharoitda til o'rganishni qo'llab-quvvatlash uchun chet tilida retseptiv va produktiv ko'nikmalarni shakllantiradigan  materiallarni yanada takomillashtirish usullari tanqidiy ko'rib chiqish zarur. Ayniqsa, ushbu maqolada  interfaol mashlar bo'yicha mavjud tadqiqotlarning pragmatik jihatiga e'tibor qaratildi. Shuningdek, hozirgi vaqtda mavjud til materiallari va autentik materiallar o'rtasidagi moslik va nomuvofiqlik muhokama qilindi.
Report of the 2011-2012 Standing Committee on Advocacy: The Relevance of Excellent Research: Strategies for Impacting Public Policy
Creators: name: Lang, William G.
name: Law, Anandi V.
name: Allen, David D.
name: Vanderveen, R. Pete
name: Lauffenburger, Julie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: According to the Bylaws of the American Association of Colleges of Pharmacy (AACP), the Advocacy Committee:
Rural Health in Pharmacy Curricula
Creators: name: Joyner, Pamela U.
name: O’Connor, Shanna K.
name: Thrasher, Kim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The 2010 Patient Protection and Affordable Care Act proposes strategies to address the workforce shortages of primary care practitioners in rural America. This review addresses the question, “What specialized education and training are colleges and schools of pharmacy providing for graduates who wish to enter pharmacy practice in rural health?” All colleges and schools accredited by the Accreditation Council for Pharmacy Education or those in precandidate status as of December 2011 were included in an Internet-based review of Web sites. A wide scope of curricular offerings were found, ranging from no description of courses or experiences in a rural setting to formally developed programs in rural pharmacy. Although the number of pharmacy colleges and schools providing either elective or required courses in rural health is encouraging, more education and training with this focus are needed to help overcome the unmet need for quality pharmacy care for rural populations.
SURESOFT: Introduction to Design Patterns
Creators: name: Linxweiler, Jan
name: Peters, Sören
name: Marcus, Sven
Publisher: name: Zenodo
Year: 2022
Subjects: RSE, Research Software Engineering, Design Patterns, SOLID Principles, Design Principles, OOP

description: As scientists, we don’t have to reinvent the wheel when it comes to software. Instead, we will make use of software design patterns that provide proven solutions for reoccurring problems. Applying design pattern will help us to achieve a higher application quality and rising the level of abstraction in documentation as well as communication with our colleagues. In this workshop, we will walk you through a code example and step by step add new features. Along the way, we will involve you in every design decisions so that you have a good understanding of the pros and cons of our final solution. It is quite possible that we will come across some design patterns along the way.
Effects of T cell leptin signaling on systemic glucose tolerance and T cell responses in obesity
Creators: name: MacIver N.J.
name: Nichols A.G.
name: Kiernan K.
name: Alwarawrah Y.
Publisher: name: Public Library of Science
Year: 2023

description: Background/Objectives Leptin is an adipokine secreted in proportion to adipocyte mass and is therefore increased in obesity. Leptin signaling has been shown to directly promote inflammatory T helper 1 (Th1) and T helper 17 (Th17) cell number and function. Since T cells have a critical role in driving inflammation and systemic glucose intolerance in obesity, we sought to determine the role of leptin signaling in this context. Methods Male and female T cell-specific leptin receptor knockout mice and littermate controls were placed on low-fat diet or high-fat diet to induce obesity for 18 weeks. Weight gain, serum glucose levels, systemic glucose tolerance, T cell metabolism, and T cell differentiation and cytokine production were examined. Results In both male and female mice, T cell-specific leptin receptor deficiency did not reverse impaired glucose tolerance in obesity, although it did prevent impaired fasting glucose levels in obese mice compared to littermate controls, in a sex dependent manner. Despite these minimal effects on systemic metabolism, T cell-specific leptin signaling was required for changes in T cell metabolism, differentiation, and cytokine production observed in mice fed high-fat diet compared to low-fat diet. Specifically, we observed increased T cell oxidative metabolism, increased CD4+ T cell IFN-γ expression, and increased proportion of T regulatory (Treg) cells in control mice fed high-fat diet compared to low-fat diet, which were not observed in the leptin receptor conditional knockout mice, suggesting that leptin receptor signaling is required for some of the inflammatory changes observed in T cells in obesity. Conclusions T cell-specific deficiency of leptin signaling alters T cell metabolism and function in obesity but has minimal effects on obesity-associated systemic metabolism. These results suggest a redundancy in cytokine receptor signaling pathways in response to inflammatory signals in obesity.
Per-Vaginal Delivery of a Congenital Arthrogryposis Foetus in A Graded Murrah Buffalo- A Case Report
Creators: name: Hema Deepthi P1 And Phani Kumar L2
Publisher: name: The Science world a Monthly e magazine
Year: 2023

description:           Arthrogryposis is a congenital musculoskeletal defect characterized by the ankylosis of limbs, often accompanied by other growth deformities such as a cleft palate. When calves are born with arthrogryposis, their joints are fixed in abnormal positions, and they may also exhibit scoliosis, kyphosis, and other deformities. This condition is more commonly observed in the forelimbs than the hind limbs, and the hind limbs are typically unaffected unless the forelimbs are also involved. When arthrogryposis is accompanied by additional deformities like kyphosis, scoliosis, torticollis, or a cleft palate, it is often referred to as Crooked Calf Disease.
Additional file 6: of Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue
Creators: name: Brodhagen, Johanna
name: Weikard, Rosemarie
name: Thom, Ulrike
name: Heimes, Annika
name: G체nther, Juliane
name: Hadlich, Frieder
name: Zerbe, Holm
name: Petzl, Wolfgang
name: Meyerholz, Marie
name: Hoedemaker, Martina
name: Hans-Joachim Schuberth
name: Engelmann, Susanne
name: K체hn, Christa
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Lists of IPA canonical pathways significantly enriched for differentially expressed genes in non-depleted (0) and depleted RNA samples (protocol variants A and B) from pathogen-challenged and non-challenged udder quarters. Pathways are classified for being observed across all protocols (0, A or B) or shared between two or all three protocols. (PDF 214 kb)
Use of SMART Learning Objectives to Introduce Continuing Professional Development Into the Pharmacy Curriculum
Creators: name: Leadon, Kim
name: Tofade, Toyin
name: Khandoobhai, Anand
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Objective. To determine whether a 2-year continuing professional development (CPD) training program improved first-year (P1) and second-year (P2) pharmacy students’ ability to write SMART (specific, measurable, achievable, relevant, and timed) learning objectives.
Additional file 2: of Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models
Creators: name: Sabol, Rachel
name: Bowles, Annie
name: Côté, Alex
name: Wise, Rachel
name: Benjamen O’Donnell
name: Matossian, Margarite
name: Fokhrul Hossain
name: Burks, Hope
name: Valle, Luis
name: Miele, Lucio
name: Collins-Burow, Bridgette
name: Burow, Matthew
name: Bunnell, Bruce
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Figure S2. TNBC xenograft growth is unaffected by ASCs. (A) Histologic analysis of tumors at end point revealed that stem cells had no effect on proliferation (ki67+ cells) or angiogenesis (CD31+ blood vessels). All images in panel were acquired at the same magnification. Scale bar represents 100 μm. (B) Representative images of metastases are shown. Image of lung section with annotation metastases are shown. Black arrows point to annotations on lung sections. All images in this panel were acquired at the same magnification. Scale bar represents 100 μm. Values reported are the mean (n = 5 mice per group). Bars, ± SEM. *p
title: Crown and community in Essex, c.1066-1189.
Creators: name: Titterington, David
Publisher: name: University of Kent
Year: 2022

description: This work explores the development of the Anglo-Norman landed community in Essex and analyses the role of the Crown in the county's contemporary affairs. It covers a period of conquest, settlement, civil war and strengthening royal government. The assessment of the role of the Crown primarily focuses upon the relationship between the king and local landowners. It also concentrates on the maintenance and extension of royal rights, the exploitation of royal justice and forest law, the promotion and retention of peace in the county, and the development and use of royal demesne. Analysis of a community relies upon defining a local group, proving their interest in a locale and subsequently demonstrating community-linked behaviour. Such proof relies upon the use of a number of indices, some of which are drawn from later concepts of County Communities (such as participation in local government and collective identity). Other factors owe their origin to wider anthropological theories (e.g. local custom, familial ties and frequent contact between subjects). The thesis makes use of the principal primary sources for the period (Domesday, Cartae Baronum, monastic chronicles, the Pipe Rolls and extant royal, baronial and ecclesiastical acta). Owing to the greater number of surviving primary documents after 1135, it is easier to assess community ties after that date. A wide range of secondary sources also exists, many of which have been utilised and, in some cases, expanded upon. This research has demonstrated that a community was evident among both the tenants-in-chief and sub-tenants of Essex from the reign of William I and that it advanced during the century that followed his death. This was partially due to the immense tenurial stability of the county at that time. It also shows that royal influence in the county was at a consistently high level, where the Crown normally had more land in Essex than any other individual. This ensured that Essex was one of the most peaceful and prosperous English counties between the accession of William the Conqueror and the death of Henry II.