cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Creators: name: Perou, Charles
name: Watson, Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples from an African-American patient with basal-like breast cancer: peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The metastasis contained two de novo mutations and a large deletion not present in the primary tumour, and was significantly enriched for 20 shared mutations. The xenograft retained all primary tumour mutations and displayed a mutation enrichment pattern that resembled the metastasis. Two overlapping large deletions, encompassing CTNNA1, were present in all three tumour samples. The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour.
The roads to non-individuals (and how not to read their maps)
Creators: name: Arenhart, Jonas R. B.
name: Arroyo, Raoni W.
Publisher: name: arXiv
Year: 2023
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Ever since its beginnings, standard quantum mechanics has been associated with a metaphysical view according to which the theory deals with non-individual objects, i.e., objects deprived of individuality in some sense of the term. We shall examine the grounds of the claim according to which quantum mechanics is so closely connected with a metaphysics of non-individuals. In particular, we discuss the attempts to learn the required `metaphysical lessons' required by quantum mechanics coming from four distinct roads: from the formalism of the theory, treating separately the case of the physics and the underlying logic; from the ontology of the theory, understood as the furniture of the world according to the theory; and, at last, we analyze whether a metaphysics of non-individuals is indispensable from a purely metaphysical point of view. We argue that neither non-individuality nor individuality is not to be found imposed on us in any of these levels so that it should be seen as a metaphysical addition to the theory, rather than as a lesson from it.
description: Forthcoming in J. R. B. Arenhart, R. W. Arroyo (eds.), Non-Reflexive Logics, Non-Individuals, and the Philosophy of Quantum Mechanics: Essays in Honour of the Philosophy of D\'ecio Krause, Springer, Synthese Library 476, https://doi.org/10.1007/978-3-031-31840-5_5
Study design recommendations in guidance documents for high-risk medical devices. A systematic review.d
Creators: name: Schnell-Inderst, Petra
name: Kühne, Felicitas
name: Rochau, Ursula
name: Schmid, Daniela
name: Siebert, Uwe
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: clinical investigation
subject: guidance
subject: medical devices
subject: trial design

description: This review is one of the tasks in the Horizon 2020 project Coordinating Research and Evidence for Medical Devices (CORE-MD), which started in April 2021 and will end in March 2024 (https://www.core-md.eu). Its mission is "Translating expert knowledge into advice for EU regulatory guidance and building expertise in regulatory science in the clinical community". This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. The objectives of this systematic review are firstly to identify guidance on the design, conduct, analysis, and reporting of confirmatory pivotal clinical trials and other clinical investigations for high-risk medical devices, from regulators, international standardization organizations, medical professional associations, academic consortia, and HTA agencies; secondly, to compare their similarities and differences; and thirdly, to identify gaps for further research on trial methodology.
Online Influence Maximization (Extended Version)
Creators: name: Lei, Siyu
name: Maniu, Silviu
name: Mo, Luyi
name: Cheng, Reynold
name: Senellart, Pierre
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: Databases (cs.DB)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Social networks are commonly used for marketing purposes. For example, free samples of a product can be given to a few influential social network users (or "seed nodes"), with the hope that they will convince their friends to buy it. One way to formalize marketers' objective is through influence maximization (or IM), whose goal is to find the best seed nodes to activate under a fixed budget, so that the number of people who get influenced in the end is maximized. Recent solutions to IM rely on the influence probability that a user influences another one. However, this probability information may be unavailable or incomplete. In this paper, we study IM in the absence of complete information on influence probability. We call this problem Online Influence Maximization (OIM) since we learn influence probabilities at the same time we run influence campaigns. To solve OIM, we propose a multiple-trial approach, where (1) some seed nodes are selected based on existing influence information; (2) an influence campaign is started with these seed nodes; and (3) users' feedback is used to update influence information. We adopt the Explore-Exploit strategy, which can select seed nodes using either the current influence probability estimation (exploit), or the confidence bound on the estimation (explore). Any existing IM algorithm can be used in this framework. We also develop an incremental algorithm that can significantly reduce the overhead of handling users' feedback information. Our experiments show that our solution is more effective than traditional IM methods on the partial information.
description: 13 pages. To appear in KDD 2015. Extended version
Depth in classical Coexter groups
Creators: name: Bagno, Eli
name: Biagioli, Riccardo
name: Novick, Mordechai
name: Woo, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The depth statistic was defined by Petersen and Tenner for an element of an arbitrary Coxeter group in terms of factorizations of the element into a product of reflections. It can also be defined as the minimal cost, given certain prescribed edge weights, for a path in the Bruhat graph from the identity to an element. We present algorithms for calculating the depth of an element of a classical Coxeter group that yield simple formulas for this statistic. We use our algorithms to characterize elements having depth equal to length. These are the short-braid-avoiding elements. We also give a characterization of the elements for which the reflection length coincides with both the depth and the length. These are the boolean elements.
Valutazione degli effetti della riforma 2003 della PAC sul mercato fondiario
Creators: name: Gallerani, Vittorio
name: Ghinassi, Andrea
name: Viaggi, Davide
Publisher: name: Aestimum
Year: 2009

description: Aestimum, Atti del XXXVII Incontro di Studio (Ferrara)
Incel Activity on Social Media Linked to Local Mating Ecology
Creators: name: Blake, Khandis
name: Brooks, Robert
name: Russo-Batterham, Daniel
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: behavioral ecology
subject: economic inequality
subject: evolutionary psychology
subject: gender equality
subject: Incels
subject: income inequality
subject: mating markets
subject: sexual selection
subject: social media
subject: Twitplat
subject: twitter

description: Registration of: Brooks, R.C., Russo-Batterham, D., & Blake, K. R. (2022). Incel Activity on Social Media Linked to Local Mating Ecology. Psychological Science. Abstract: Young men with few prospects of attracting a mate have historically threatened internal peace and stability of societies. In some contemporary societies, such involuntary celibate ¬– or Incel – men perpetrate much online misogyny and real-world violence. We test the prediction that online Incel activity arises via local ‘real world’ mating market forces that affect relationship formation. From a database of 4 billion Twitter posts (2012-2018), we geolocated 321 million to 582 commuting zones in the continental U.S.A., of which 3649 tweets used words peculiar to Incels and 3745 were about Incels. We show that such tweets arise disproportionately within places where mating competition among men is likely to be high due to male-biased sex ratios, few single women, high income inequality, and small gender gaps. Our results suggest a role for social media in monitoring and mitigating factors that lead young men toward antisocial behavior in real-world societies.
Stima degli effetti individuali sulla disponibilità a pagare da responsi dicotomici con reiterazione: escursionisti e villeggianti in visita al Parco Nazionale del Gran Paradiso
Creators: name: Scarpa, Riccardo
name: Bravi, Marina
Publisher: name: Aestimum
Year: 2009

description: Numerosi studiosi italiani che si interessano di valori ricreativi stanno prestando una crescente attenzione ai metodi di valutazione basati sulle cosiddette preferenze affermate, e, in special modo, alla valutazione contingente (CV) (esempi recenti sono Tempesta, 1996; Marangon e Tempesta 1998). Questi studi hanno ancora, almeno in parte, obiettivi di tipo sperimentale e mirano ad identificare la performance nel contesto italiano di questa metodologia sviluppata prevalentemente in ambito anglosassone. In tale contesto risultano, ad esempio, di un certo interesse gli studi che tentano una validazione delle stime CV tramite il confronto con altre tecniche, in special modo il metodo costo di viaggio (TC) (cfr. Romano e Carbone 1993; Romano e Rossi 1994). I1 panorama di applicazioni italiane di queste metodologie è esteso ben oltre i semplici valori ricreativi, come è facilmente dimostrabile sfogliando la rassegna di saggi e applicazioni contenuta in Bishop e Romano (1998)
description: Aestimum, Aestimum 38 (1999)
From Disordered Quantum Walk to Physics of Off-diagonal Disorder
Creators: name: Zhao, Qifang
name: Gong, Jiangbin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Systems with purely off-diagonal disorder have peculiar features such as the localization-delocalization transition and long-range correlations in their wavefunctions. To motivate possible experimental studies of the physics of off-diagonal disorder, we study in detail disordered discrete-time quantum walk in a finite chain, where the diagonal disorder can be set to zero by construction. Starting from a transfer matrix approach, we show, both theoretically and computationally, that the dynamics of the quantum walk with disorder manifests all the main features of off-diagonal disorder. We also propose how to prepare a remarkable delocalized zero-mode from a localized and easy-to-prepare initial state using an adiabatic protocol that increases the disorder strength slowly. Numerical experiments are also performed with encouraging results.
description: 15 pages, 10 figures, submitted to PRB
Impact evaluation of training natural leaders during a community-led total sanitation intervention: a cluster-randomized field trial in Ghana
Creators: name: Bartram, Jamie
name: Crocker, Jonny
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We used a cluster-randomized field trial to evaluate training natural leaders (NLs) as an addition to a community-led total sanitation (CLTS) intervention in Ghana. NLs are motivated community members who influence their peers’ behaviors during CLTS. The outcomes were latrine use and quality, which were assessed from surveys and direct observation. From October 2012, Plan International Ghana (Plan) implemented CLTS in 60 villages in three regions in Ghana. After 5 months, Plan trained eight NLs from a randomly selected half of the villages, then continued implementing CLTS in all villages for 12 more months. The NL training led to increased time spent on CLTS by
community members, increased latrine construction, and a 19.9 percentage point reduction in open defecation (p < 0.001). The training had the largest impact in small, remote villages with low exposure to prior water and sanitation projects, and may be most effective in socially cohesive villages. For both interventions, latrines built during CLTS were less likely to be constructed of durable materials than pre-existing latrines, but were equally clean, and more often had handwashing materials. CLTS with NL training contributes to three parts of Goal 6 of the Sustainable Development Goals: eliminating open defecation, expanding capacity-building, and strengthening community participation.
Direct Bandgap Light Emission from Strained Ge Nanowires Coupled with High-Q Optical Cavities
Creators: name: Petykiewicz, Jan
name: Nam, Donguk
name: Sukhdeo, David S.
name: Gupta, Shashank
name: Buckley, Sonia
name: Piggott, Alexander Y.
name: Vučković, Jelena
name: Saraswat, Krishna C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A silicon-compatible light source is the final missing piece for completing high-speed, low-power on-chip optical interconnects. In this paper, we present a germanium-based light emitter that encompasses all the aspects of potential low-threshold lasers: highly strained germanium gain medium, strain-induced pseudo-heterostructure, and high-Q optical cavity. Our light emitting structure presents greatly enhanced photoluminescence into cavity modes with measured quality factors of up to 2,000. The emission wavelength is tuned over more than 400 nm with a single lithography step. We find increased optical gain in optical cavities formed with germanium under high (>2.3%) tensile strain. Through quantitative analysis of gain/loss mechanisms, we find that free carrier absorption from the hole bands dominates the gain, resulting in no net gain even from highly strained, n-type doped germanium.
description: J.P. and D.N. contributed equally to this work
title:  Sostenibilità. Una questione di etica sociale
Creators: name: Moschini  , Laura
Publisher: name: Roma TrE-Press
Year: 2021

description: I temi della sostenibilità e dell’ambiente sono oggi considerati prioritari negli obiet­tivi della strategia europea per un’efficace ripresa post pandemica che guardi anche alle future generazioni e al loro benessere. Se il primato delle tecnologie, e la digitalizzazione viene collegata con la sostenibilità, l’attenzione alla persona e alla sua felicità richiede un forte richiamo a un uso responsabile di esse e alla valutazione dei possibili impatti sulla vita dei singoli individui, delle co­munità e della Terra stessa. Si tratta di una valutazione di carattere etico che può essere assicurata solo da un continuo rapporto tra i saperi, nella consapevolezza che molti e diversi sono gli aspetti da considerare, ma soprattutto si deve indagare il ‘senso’ della direzione verso cui stiamo andando.

The issues of sustainability and the environment are now considered priorities in the objectives of the European strategy for an effective post-pandemic recovery that also looks to future generations and their well-being. If the primacy of technologies, and digitalization, are linked to sustainability, the focus on the individual and his or her happiness requires a strong call for a responsible use of them and an assessment of the possible impacts on the lives of individuals, communities and the Earth itself. This is an ethical assessment, ensured by a continuous relationship between different areas of knowledge, in the understanding that there are many different aspects to be considered, but above all the ‘sense’ of the direction in which we are going must be investigated.
description: B@belonline vol. speciale 2021 Il nuovo atlante di Sophia/ Sophia’s New Atlas
The Contemporary Era: Sustainable Development and the Resurgence of Public Investment Law
Creators: name: Nasirli, Farid
Publisher: name: Zenodo
Year: 2025

description: The resurgence of public investment in the contemporary era is inextricably linked to the evolution of Public Investment Law (PIL), particularly in sustainable development imperatives and the changing dynamics of state-market relations. This article takes a close look at the changes in the law that have affected public investment frameworks in the 21st century. It focuses on how PIL has changed to include environmental, social, and governance (ESG) standards, change the way investors and states interact, and protect the sovereign right to regulate in the public interest. This paper uses comparative legal analyses, international soft law developments, doctrinal theories, and leading jurisprudence to show how national legal systems, international investment law, and sustainable development goals affect each other in complex ways1.
Causal Learning
Creators: name: Leshinskaya, Anna
name: Ranganath, Charan
name: Boorman, Erie
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cognitive Neuroscience
subject: Life Sciences
subject: Cognitive Psychology
subject: Neuroscience and Neurobiology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This is a pre-analysis pre-registration of this project. Some data (n = 7) have been collected but are not yet analyzed. The documents contain a full description of the aims of the projects, the methodological details, and analysis strategy.
Detection of flubromazolam in patients with suspected non-medical drug use attending emergency departments in the United Kingdom
Creators: name: Haden, Mark
name: Cashman, Josephine
name: Ketchin, Andrew
name: Macfarlane, Rebecca
name: Issa, Shabana
name: Eddleston, Michael
name: Hines, Selina
name: Hudson, Simon
name: Hill, Simon L.
name: Thomas, Simon H. L.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Non-medical use of novel benzodiazepines has recently become common. Here, we describe the recent frequent detection of flubromazolam in patients attending United Kingdom emergency departments. Adults presenting to participating hospitals with toxicity after suspected drug misuse were studied between March 2015 and January 2021. Clinical features were recorded using consistent methodology and biological samples analysed using liquid chromatography–tandem mass-spectrometry. Flubromazolam and/or its mono-hydroxylated metabolite were detected in samples from 14 of 957 patients, all presenting since July 2020. Reported clinical features included reduced level of consciousness (10), confusion/agitation (6) and acidosis (5) but multiple other substances were detected in all patients. All patients survived to discharge (length of hospital stay 3.0 to 213 h, median 24.1 h). There was no correlation between admission blood/serum flubromazolam concentrations (range 1.7–480.5 ng/ml, median 7.4 ng/ml) and Glasgow Coma Scale or length of hospital stay. In one patient who needed intubation and ventilation for five days, there was an exponential decline in flubromazolam concentrations with time (calculated half-life 39.8 h). Hydroxyl-flubromazolam was also identified at all time points. Flubromazolam has been detected frequently in drug users presenting to UK emergency departments since July 2020. Prolonged toxicity may occur as a result of the long half-life of flubromazolam and the production of metabolites likely to be active.
השפעת טון דיבור המדריכ.ה בתרגול מיינדפולנס על חרדה מצבית
Creators: name: harambam, ido
name: Berman, Shlomo
name: manovich, sahar
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: anxiety
subject: mindfulness
subject: #psychology
subject: STAI
subject: voice

description: זוהי הרשמה מראש למחקר שלנו במסגרת הקורס "פסיכולוגיה ניסויית" באוניברסיטת תל אביב, שנת תשפ"ב 2022
title: Maintenance and Repair (NWP-2013-199-7, Port of Longview)
titleType: AlternativeTitle
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Port of Longview Routine Repair & Maintenance Projects, Longview, Washington (NWP-2013-199-7)
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2023

description: WCRO-2022-01443
title: Fish Haven 13
titleType: AlternativeTitle
title: Endangered Species Act - Section 7 Consultation Biological Opinion Modification of existing permit for Mississippi Gulf Fishing Banks Artificial Reef – Fish Haven 13
Creators: name: United States. National Marine Fisheries Service. Southeast Region
Publisher: name: United States. National Marine Fisheries Service. Southeast Region
Year: 2023

description: SERO-2022-00868
Locally Supported Wavelets for the Separation of Spherical Vector Fields with Respect to their Sources
Creators: name: Gerhards, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We provide a space domain oriented separation of magnetic fields into parts generated by sources in the exterior and sources in the interior of a given sphere. The separation itself is well-known in geomagnetic modeling, usually in terms of a spherical harmonic analysis or a wavelet analysis that is spherical harmonic based. In contrast to these frequency oriented methods, we use a more spatially oriented approach in this paper. We derive integral representations with explicitly known convolution kernels. Regularizing these singular kernels allows a multiscale representation of the internal and external contributions to the magnetic field with locally supported wavelets. This representation is applied to a set of CHAMP data for crustal field modeling.
Streptacis gundyensis Yoo 1994, n.sp.
Creators: name: Yoo, E. K.
Publisher: name: Zenodo
Year: 1994
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Heterostropha
Streptacididae
Streptacis

description: Streptacis gundyensis n.sp. PI. 23 figs 8-13 Description. Shell minute, high-spired, anomphalous. Protoconch of IV! whorls, deviated. Teleoconch of 5 to 6 smooth, moderately convex whorls, with faint growth lines. Aperture circular to oval, lips thin, no columellar fold. Dimensions. H W NW Holotype (F78522) 2.5 mm 0.9 mm 7 Paratypes (F78528 a) 2.1 0.8 6 (F78528 b)2.7 1.0 8 (F78531) 1.4 0.7 5 Types. Holotype (F78522) and 3 figured paratypes (F78528, 78531). Type locality. 150 m west of 'Marohn' homestead, 4 km south-west of Gundy, NSW (Locality 28). Stratigraphic position. In bioclastic limestone, upper part of the Dangarfield Formation. Geographic distribution. Type locality only. Geological age. Late Tournaisian. Etymology. Referring to the township of Gundy, New South Wales. Remarks. This species is similar to Kimina sp., in having smooth convex whorls with deviated protoconch, but Kimina sp. has a moderate umbilicus and more convex whorls with opisthocline growth lines.
description: Published as part of Yoo, E. K., 1994, Early Carboniferous Gastropoda from the Tamworth Belt, New South Wales, Australia, pp. 63-120 in Records of the Australian Museum 46 (1) on pages 93-94, DOI: 10.3853/j.0067-1975.46.1994.18, http://zenodo.org/record/4654599
title: Eel River Bridge Seismic Retrofit Project
titleType: AlternativeTitle
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson–Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Eel River Bridge Seismic Retrofit Project in Humboldt County, California [EA 01-0A111/EFIS 01-1600-0148]
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2023

description: WCRO-2023-00778
Gli esperimenti di scelta a supporto della pianificazione forestale in Sicilia
Creators: name: De Salvo, Maria
name: Signorello, Giovanni
name: Missiato, Arturo
Publisher: name: Aestimum
Year: 2012

description: This paper reports on main results of a choice experiments carried out to estimate several hypothetical afforestation and forest protection programmes in Sicily. The econometric analysis of data relies on logit models. The best econometric performance is shown by models which take into account heterogeneity in individual preferences. Results reveal that individual preferences can be grouped in discrete latent classes.
description: Aestimum, Aestimum 60 (2012)
Deep neural network improves the estimation of polygenic risk scores for breast cancer
Creators: name: Badré, Adrien
name: Zhang, Li
name: Muchero, Wellington
name: Reynolds, Justin C.
name: Pan, Chongle
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Machine Learning (cs.LG)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Polygenic risk scores (PRS) estimate the genetic risk of an individual for a complex disease based on many genetic variants across the whole genome. In this study, we compared a series of computational models for estimation of breast cancer PRS. A deep neural network (DNN) was found to outperform alternative machine learning techniques and established statistical algorithms, including BLUP, BayesA and LDpred. In the test cohort with 50% prevalence, the Area Under the receiver operating characteristic Curve (AUC) were 67.4% for DNN, 64.2% for BLUP, 64.5% for BayesA, and 62.4% for LDpred. BLUP, BayesA, and LPpred all generated PRS that followed a normal distribution in the case population. However, the PRS generated by DNN in the case population followed a bi-modal distribution composed of two normal distributions with distinctly different means. This suggests that DNN was able to separate the case population into a high-genetic-risk case sub-population with an average PRS significantly higher than the control population and a normal-genetic-risk case sub-population with an average PRS similar to the control population. This allowed DNN to achieve 18.8% recall at 90% precision in the test cohort with 50% prevalence, which can be extrapolated to 65.4% recall at 20% precision in a general population with 12% prevalence. Interpretation of the DNN model identified salient variants that were assigned insignificant p-values by association studies, but were important for DNN prediction. These variants may be associated with the phenotype through non-linear relationships.
description: 28 pages, 7 figures, 2 Tables
Maximal Independent Sets for Pooling in Graph Neural Networks
Creators: name: Stanovic, Stevan
name: Gaüzère, Benoit
name: Brun, Luc
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Convolutional Neural Networks (CNNs) have enabled major advances in image classification through convolution and pooling. In particular, image pooling transforms a connected discrete lattice into a reduced lattice with the same connectivity and allows reduction functions to consider all pixels in an image. However, there is no pooling that satisfies these properties for graphs. In fact, traditional graph pooling methods suffer from at least one of the following drawbacks: Graph disconnection or overconnection, low decimation ratio, and deletion of large parts of graphs. In this paper, we present three pooling methods based on the notion of maximal independent sets that avoid these pitfalls. Our experimental results confirm the relevance of maximal independent set constraints for graph pooling.
Estimation of the risk of local and systemic effects in infants after ingestion of low-concentrated weak acids from descaling products
Creators: name: Koppen, Arjen
name: Hunault, Claudine C.
name: van Kleef, Regina G. D. M.
name: van Velzen, Agnes G.
name: Westerink, Remco H. S.
name: de Vries, Irma
name: de Lange, Dylan W.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: The accidental ingestion of diluted household descaling products by infants is a phenomenon that poison control centers regularly encounter. Feeding infants with baby milk prepared with water from electric kettles still containing descaler is a common way of exposure. This study aimed to determine the risks related to ingestion of (diluted) descalers by infants. pH measurements were performed using acetic acid and three different commercially available electric kettle descalers. The pH of different dilutions was measured in the absence or presence of baby milk powder. In addition, an overview was made of pH values of different electric kettle descalers as given by the product information of the manufacturer. Finally, a simple pharmacokinetic (PK) model was used to predict changes in blood pH in infants after ingestion of acetic acid, which is the most commonly used descaler. Several commercially available electric kettle descalers have a pH <2. Even after diluting such descalers up to 10 times the pH can remain low. The addition of milk powder increases the pH of descalers containing weaker acids, with a pH >1.5, while descalers with stronger acids and pH <1 show little pH increase after the addition of milk powder. Finally, a simple PBPK model for the ingestion of acetic acid predicted that the ingestion of larger amounts of acetic acid (>1000 mg) by an infant could result in relevant changes in blood pH. Commercially available electric kettle descaling products may pose a health risk to infants in case of accidental ingestion since the pH of some of these products can be very low, even when diluted 10-times or in the presence of baby milk powder. Oral exposure of infants to the common descaler acetic acid, after accidental preparation of baby milk with cleaning vinegar, will probably not result in serious local effects, but changes in blood pH cannot be excluded when larger amounts of acetic acid are ingested.
Supplementary document for A portable, smartphone-linked, and miniaturized Photonic Resonator Absorption Microscope (PRAM Mini) for point-of-care diagnostics - 7153281.pdf
Creators: name: Khemtonglang, Kodchakorn
name: Liu, Weinan
name: Lee, Hankeun
name: Wang, Weijing
name: Li, Siyan
name: Li, James
name: Shepherd, Skye
name: Diel, Diego
name: Fang, Ying
name: Cunningham, Brian
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Photonics and Electro-Optical Engineering (excl. Communications)

description: CAD drawings of the optical fixtures, Application user interfaces, Photographs of internal design, Video screenshots of the DDC application, and source codes for camera control and counting algorithm
Variable Reddening and Broad Absorption Lines in the Narrow-line Seyfert 1 Galaxy WPVS 007: an Origin in the Torus
Creators: name: Leighly, Karen M.
name: Cooper, Erin
name: Grupe, Dirk
name: Terndrup, Donald M.
name: Komossa, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the discovery of an occultation event in the low-luminosity narrow-line Seyfert 1 galaxy WPVS 007 in 2015 February and March. In concert with longer timescale variability, these observations place strong constraints on the nature and location of the absorbing material. Swift monitoring has revealed a secular decrease since ~2010 accompanied by flattening of the optical and UV photometry that suggests variable reddening. Analysis of four Hubble Space Telescope COS observations since 2010, including a Director's Discretionary time observation during the occultation, shows that the broad-absorption-line velocity offset and the CIV emission-line width both decrease as the reddening increases. The occultation dynamical timescale, the BAL variability dynamical timescale, and the density of the BAL gas show that both the reddening material and the broad-absorption-line gas are consistent with an origin in the torus. These observations can be explained by a scenario in which the torus is clumpy with variable scale height, and the BAL gas is blown from the torus material like spray from the crest of a wave. As the obscuring material passes into our line of sight, we alternately see high-velocity broad absorption lines and a clear view to the central engine, or low-velocity broad absorption lines and strong reddening. WPVS 007 has a small black hole mass, and correspondingly short timescales, and so we may be observing behavior that is common in BALQSOs, but is not typically observable.
description: Accepted for publication in ApJ Letters
Focal adhesions: A nexus for intracellular signaling and cytoskeletal dynamics
Creators: name: Burridge, Keith
name: Sastry, Sarita K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Focal adhesions (FAs) are specialized sites of cell attachment to the extracellular matrix (ECM) where integrin receptors link the ECM to the actin cytoskeleton. Integrins cluster into supramolecular complexes with structural, cytoskeletal proteins like talin, vinculin, and a-actinin, as well as numerous signaling molecules, including c-Src, FAK, p130cas, and paxillin. The composition and molecular architecture of FAs have been reviewed elsewhere and are beyond the scope of this brief review. FAs serve at least two significant cellular functions: to transmit force or tension at adhesion sites to maintain strong attachments to the underlying ECM and to act as signaling centers from which numerous intracellular pathways emanate to regulate cell growth, survival, and gene expression. FAs are dynamic structures that assemble, disperse, and recycle (turnover) as cells migrate or enter into mitosis. Recent evidence reveals the complexity of these processes. Assembly/disassembly involves the coordinate regulation of Rho family GTPases through cross talk between integrins and numerous adhesion receptors (cadherins, cell adhesion molecules (CAMs), selectins, and syndecans), G-protein-coupled receptors (GPCRs), and receptor tyrosine kinases (RTKs), as well as the interplay between microtubules and actin. It is also apparent that FAs are themselves motile and heterogeneous in composition. Finally, turnover of FAs entails communication with components of vesicle trafficking pathways and microtubules. This review highlights recent findings relating to FA assembly, dynamics, and turnover.
The value spatial component in the Real Estate Market: the Turin case study
Creators: name: Fregonara, Elena
name: Rolando, Diana
name: Semeraro, Patrizia
Publisher: name: Aestimum
Year: 2012

description: In the study of variables affecting the determination of property prices, the spatial component is playing an increasingly significant role. In order to quantify the property value variability due to its location, it is necessary to resort to spatial statistics. The aim of this paper is twofold. On the one hand, we propose a geostatistical model aimed at identifying the incidence of position on housing asking prices. Starting from a geostatistical model we propose a methodology to empirically measure the incidence of a geographical segmentation on asking prices. The purpose of this paper is to test whether appraisers take account of the location in defining the asking prices, that represent the first signal of houses values. The proposed model is tested on a sample of residential properties, listed on the Turin real estate market. On the other hand, staring from the results of the model, the purpose of the present work is to formulate economic-estimative interpretations of the Turin real estate market dynamics.
description: Aestimum, Aestimum 60 (2012)
Detection of flubromazolam in patients with suspected non-medical drug use attending emergency departments in the United Kingdom
Creators: name: Hayden, Mark
name: Cashman, Josephine
name: Ketchin, Andrew
name: Macfarlane, Rebecca
name: Issa, Shabana
name: Eddleston, Michael
name: Hines, Selina
name: Hudson, Simon
name: Hill, Simon L.
name: Thomas, Simon H. L.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Non-medical use of novel benzodiazepines has recently become common. Here, we describe the recent frequent detection of flubromazolam in patients attending United Kingdom emergency departments. Adults presenting to participating hospitals with toxicity after suspected drug misuse were studied between March 2015 and January 2021. Clinical features were recorded using consistent methodology and biological samples analysed using liquid chromatography–tandem mass-spectrometry. Flubromazolam and/or its mono-hydroxylated metabolite were detected in samples from 14 of 957 patients, all presenting since July 2020. Reported clinical features included reduced level of consciousness (10), confusion/agitation (6) and acidosis (5) but multiple other substances were detected in all patients. All patients survived to discharge (length of hospital stay 3.0 to 213 h, median 24.1 h). There was no correlation between admission blood/serum flubromazolam concentrations (range 1.7–480.5 ng/ml, median 7.4 ng/ml) and Glasgow Coma Scale or length of hospital stay. In one patient who needed intubation and ventilation for five days, there was an exponential decline in flubromazolam concentrations with time (calculated half-life 39.8 h). Hydroxyl-flubromazolam was also identified at all time points. Flubromazolam has been detected frequently in drug users presenting to UK emergency departments since July 2020. Prolonged toxicity may occur as a result of the long half-life of flubromazolam and the production of metabolites likely to be active.
Real estate function impact on its value exemplified by the city of Gdańsk
Creators: name: Wojewnik- Filipkowska, Anna
name: Rymarzak, Małgorzata
name: Trojanowski, Dariusz
Publisher: name: Aestimum
Year: 2013

description: Spatial planning is connected with speculations in real estate market, which deepens the process of urban sprawl. Adequate land management supporting free market – both investment decision of businesses and location decisions of households – is necessary if amorphous city growth is to be prevented. A change, or even information about change in the local plan determines decisions in the real estate market. On the basis of the studies conducted it can be said that the factor causing the greatest value increment is the possibility of development. To assess the possible success of investment projects and the value of real estate it is important to identify the changes that have been occurring in the growth of urban areas and their suburban expansion; whether they follow a certain pattern and whether it is possible to foresee them. The article presents city growth stages and models as well as selected concepts of sustainable growth as a response to the adverse process of suburbanisation.
description: Aestimum, Aestimum 61 (2012)
Predictors of noncompliance in patients with schizophrenia
Creators: name: Perkins, Diana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Background: Around 50% of patients with schizophrenia do not fully comply with treatment, and noncompliance is linked to relapse, rehospitalization, poor outcome, and high economic costs. The health belief model views noncompliance as a decision made by the patient, arrived at after weighing the perceived risks and benefits of treatment. Data sources: A MEDLINE search for the years 1980-2002 using combinations of the keywords schizophrenia, compliance, adherence, antipsychotics, tolerability, and side effects was used to identify articles investigating the factors influencing compliance in schizophrenia. Results: Many factors influence compliance, including those that affect patients' beliefs about their illness and the benefits of treatment (e.g., insight into illness, belief that medication can ameliorate symptoms), perceived costs of treatment (e.g., medication side effects), and barriers to treatment (e.g., ease of access to treatment, degree of family or social support). Medication side effects that are distressing to patients and linked to noncompliance include extrapyramidal side effects, neuroleptic dysphoria, akathisia, sexual dysfunction, and weight gain. Compliance can be improved by cognitive-behavioral therapies, such as compliance therapy, and other psychosocial interventions associated with improved social functioning and a lower risk of rehospitalization. Treatment adherence may also be improved by use of atypical antipsychotics with few perceived side effects. Conclusion: By considering the factors leading to noncompliance and adopting a comprehensive strategy for improving compliance, encompassing psychosocial intervention and optimum choice of medication, the management of schizophrenia could be greatly improved.
Analysis of Real Estate market Cycles: an application on Italian data
Creators: name: Festa, Maurizio
name: Ghiraldo, Erika
name: Storniolo, Alessandra
Publisher: name: Aestimum
Year: 2013

description: Using Italian data, on the basis of economic theoretical approach of the honeycomb cycle by Janssen, Kruijt and Needham in 1994, this article proposes a further development in the study of the dynamics of real estate housing market in Italy. Using the market indicators, we plot the “honeycomb cycle” graph for each region and greatest Italian cities. Regions showing similar patterns are grouped using cluster analysis method. This practical work reaches its particular goal examining the national territory in terms of development and its evolution.
description: Aestimum, XLI Meetings Proceedings (Rome)
Development of multicriteria modules for environmental valu- ation in GRASS GIS
Creators: name: Massei, G.
name: Rocchi, L.
name: Paolotti, L.
name: Boggia, A.
Publisher: name: Aestimum
Year: 2014

description: Dealing with spatial decision problems means very often to face a GIS and a multi-criteria decision analysis based problem at the same time. GIS and Multi-criteria Decision Analysis are two well defined research areas, but both can benefit one from each other. In the last twenty years several researches have paid attention to MCDA-GIS integration and to the development of Spatial Decision Support Systems (SDSS), but few papers presented examples of perfect integration. Also in case of perfect integration, they often integrate within GIS only one multicriteria model. Our application is a better contribution in this way. We developed four GRASS modules that permit to implement four different MCDA methods: the Regime, the FUZZY, the ELECTRE and the Dominance-based Rough Set Approach. One of the main advantages of our application over the previous ones is the possibility of a future development in an open-source context. The paper presents an application of the Regime, Electre and Fuzzy modules.
description: Aestimum, Aestimum 63 (2013)
Il futuro ruolo dell’agricoltore nella produzione di energia: prospettive e rischi nella costruzione della filiera
Creators: name: Castellini, Alessandra
name: Pirazzoli, Carlo
name: Ragazzoni, Alessandro
Publisher: name: Aestimum
Year: 2009

description: Aestimum, Atti del XXXVII Incontro di Studio (Ferrara)
Space-time correlations in turbulent flow: A review
Creators: name: Wallace, James M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: This paper reviews some of the principal uses, over almost seven decades, of correlations, in both Eulerian and Lagrangian frames of reference, of properties of turbulent flows at variable spatial locations and variable time instants. Commonly called space--time correlations, they have been fundamental to theories and models of turbulence as well as for the analyses of experimental and direct numerical simulation turbulence data.
description: 16 pages, 7 figures
Survey of biomedical and health care informatics programs in the United States
Creators: name: Kampov-Polevoi, Julia
name: Hemminger, Bradley M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Informatics, in the classic definition, is a science that studies “the representation, processing, and communication of information in natural and artificial systems” or, more pragmatically, “a discipline focused on the acquisition, storage, and use of information in a specific setting or domain”, such as health care or biomedical sciences. Informatics is also increasingly described as a profession that is still at the early stages of development. There is continuing self-identification of different subfields of informatics, particularly those related to biomedicine and health care, both as scientific disciplines and as professions. One aspect of defining a profession or a subspecialty within it is establishing a set of agreed upon competencies and corresponding educational curricula. Yet, while the number of programs “with ‘informatics’ in their names” is growing, these programs vary substantially in level and scope. Our survey attempts to provide a snapshot of the current picture of informatics training programs related to biomedicine and health care in the United States. The purpose of the survey is twofold. First, the survey is intended as a resource for students, educators, and informatics professionals. Second, through compiling detailed information about existing educational opportunities, we attempt to contribute to the definitions of various informatics subspecialties. This is the fifth generation of surveys of informatics programs conducted by our research group; previous surveys were published online. The first three surveys, carried out annually in 2002–2004, focused only on bioinformatics programs. In more recent iterations (2006 and current, 2008, versions), we moved to a biannual schedule, but broadened the survey scope to encompass medical, health, nursing, dental, and other related informatics programs. In the latest survey presented in this paper, we have also significantly expanded the information categories used to describe each program and paid special attention to grouping the program listings to better correspond to the various informatics subdisciplines. A number of web resources provide similar information, such as the International Society for Computational Biology's listing of degree and certificate programs or the American Medical Informatics Association's list of training programs. Our survey differs from such resources in several important ways: It cuts across the diversity of biomedical and health informatics subspecialties; it provides specific and detailed information for each program; and it presents the information in a way that facilitates comparison of programs within and between subspecialties.