cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Oral history interview with Virendra Dayal, 2002
Publisher: name: Columbia University
Year: 2020
Subjects: Educational equalization--India
Poverty--Government policy--India
Refugees--Bangladesh

description: Early life, family background, youth and activism in Indian institutions; born in India, educated during the time of Independence 1945-47 (St. Stephens Dehli, Oxford University-University College, Indian Rhodes Scholar); impact of the Second World War and the end of the Depression in India, independence; moved by displacement stories when he was young, later involved in Refuge settlement for UN during Bangledeshi Independence 1971; diplomatic stance on development, Independence struggling, picturesque Metrople description, Indian partition imageries; part of the Indian delegation to the World Conference on Human Rights, member of the Carnegie Commission on Preventing Deadly Conflicts, currently the executive director of India's National Human Rights Commission, always a dedicated civil servant of the government of India; focuses on raising questions on democratization of education, poverty and marginalization
Preferences of pregnant women toward a future maternal Group B Streptococcus vaccine in China: A cross-sectional survey with a discrete choice experiment
Creators: name: Du, Jiaxi
name: Ji, Wenjing
name: Zhao, Hang
name: McIver, David J.
name: Zhao, Yifei
name: Chang, Jie
name: Fang, Yu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Group B streptococcus (GBS) is a major cause of neonatal death worldwide. A GBS vaccine for pregnant women is under development and is expected to be available in the near future. The perceptions and preferences of pregnant women in China of GBS vaccines has not been investigated, and this study aimed to investigate pregnant women‘s awareness of GBS and their potential preferences for the GBS vaccine. A discrete choice experiment was conducted among pregnant women in hospitals from Shaanxi, Hunan, and Zhejiang provinces located in Western, Central, and Eastern China, respectively. A conditional logit model was used to analyze the data and calculate willingness to pay values and choice probabilities of different GBS vaccine programs. A total of 354 pregnant women were included in the final analysis, 45.8% of whom were willing to receive a GBS vaccine if it were licensed. Vaccine safety was the most important attribute of a future vaccine, while cost was the least important attribute. Compared with no vaccination, pregnant women had a strong preference for future GBS vaccination (ASC = 1.267, p < .001). Pregnant women’s decisions were highly influenced by those of other pregnant women. Improving the safety, efficacy, and vaccination rate of the GBS vaccine in China is of great significance for future GBS vaccine development and vaccination. Compared to other variable options, the cost of a GBS vaccine was of the least importance among pregnant women in mainland China. These findings can inform public health policy decisions related to GBS vaccination in China.
The safety and efficacy of peroral endoscopic cardial constriction in gastroesophageal reflux disease
Creators: name: Jiang, Wenxi
name: Chen, Guangwu
name: Dong, Caijuan
name: Zhu, Shefeng
name: Pan, Jiaqi
name: Liu, Zhaoxue
name: Li, Meng
name: Yu, Chaohui
name: Shen, Zhe
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Gastroesophageal reflux disease (GERD) is one of the most common digestive disorders, which seriously affects the quality of life and brings a heavy burden to the medical care. Peroral endoscopic cardial constriction (PECC) can narrow the cardia through mucosal ligation to alleviate acid reflux symptoms. This study aims to assess the clinical efficacy of PECC. This was a retrospective case series including patients diagnosed with GERD and undergoing PECC from September 2019 to July 2021. GERD-Q questionnaire and GERD-QOL questionnaire were applied to evaluate the symptom severity and the impact of life because of GERD. A total of 16 patients were included in our study. The mean GERD-Q score was 10.94 ± 2.11 before PECC, while 5.38 ± 3.90 after PECC. The mean GERD-QOL score was 43.60 ± 16.94 before PECC, while 73.65 ± 22.08 after PECC. 62.5% of patients were satisfied with the symptom control and no serious complications were reported in our study. PECC is an efficient and safe minimally invasive endoscopic intervention for GERD. It can significantly improve GERD-related symptoms and quality of life.
title: 01_2058
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Super-resolution from Quantum Metamaterials
Creators: name: Bak, Alexey Olegovich
Publisher: name: Imperial College London
Year: 2014

description: Negative refraction and sub-wavelength resolution have been demonstrated with metamaterials throughout the past decade. This thesis introduces a quantum metamaterial, based on quantum mechanical principles, which exhibits negative refraction and sub-wavelength resolution with reduced absorption compared to non-quantum metamaterials. In particular, this thesis introduces a novel method of achieving sub-wavelength resolution using the quantum metamaterial. This method of superresolution does not require a negative permittivity or permeability, as the predecessors require, but is instead based on a dispersion curve with a high elliptical eccentricity. This thesis uses an effective medium approach to calculate the quantum metamaterial’s permittivity, which is then used to model super-resolution and negative refraction. After considerable design, optimisation and epitaxial growths, a GaAs based quantum metamaterial is fabricated into a superlens. A scanning near-field optical microscope is used to measure the sub-wavelength imaging capability of the quantum metamaterial superlens.
Formosanin C induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR signaling pathway
Creators: name: Chen, Ping
name: Wu, Sungui
name: Dong, Xiaoqing
name: Zhou, Min
name: Xu, Peipei
name: Chen, Bing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Multiple myeloma (MM) is an incurable plasma cell malignancy associated with poor survival. Novel therapeutic drugs are urgently needed to improve MM therapy and patient outcomes. This study aimed to investigate the effect of formosanin C (FC), a Chinese medicine monomer, on MM in vitro and disclose the underlying molecular mechanism. The effect of FC on the viability, proliferation, apoptosis, and autophagy of MM cell lines (NCI-H929 and ARP1) was studied through CCK-8, colony formation, flow cytometry, GFP-LC3, and western blotting assays, respectively. A pharmacological approach and network pharmacology technology were implemented to explore the potential mechanisms of the action of FC on MM cells. FC efficiently suppressed the viability and colony-forming capacity, but promoted the number of autophagic vacuoles with GFP-LC3 localization and the percentage of apoptotic cells in MM cells. Additionally, FC significantly increased the levels of the autophagy-related proteins LC3-Ⅱ and Beclin 1, as well as the apoptosis-related proteins Bax and cleaved caspase-3, but blocked the expression of the proapoptotic protein Bcl-2 in the cells; these effects were reversed by an inhibitor of autophagy, 3-methyladenine. What's more, we found that the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway was involved in the FC-mediated inhibition of MM. Pharmacological inhibition of this pathway dramatically relieved FC-triggered excessive expression of autophagy-related proteins and rescued MM cells from FC-induced apoptosis. Our findings indicate that FC exhibits an anti-MM effect by activating cell autophagy through the PI3K/AKT/mTOR signaling pathway.
Complete pathological remission and tertiary lymphoid structures are associated with the efficacy of resectable NSCLC receiving neoadjuvant chemoimmunotherapy: A double-center retrospective study
Creators: name: Liu, Ying
name: Xiong, Lei
name: Chen, Yue
name: Cai, Ruoxue
name: Xu, Xinyu
name: Wang, Tian
name: Guo, Yiyu
name: Ruan, Luxi
name: Fang, Ying
name: Zhang, Quanan
name: Shen, Bo
name: Ye, Jinjun
name: Zhou, Guoren
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: This study aimed to investigate the relationship between complete pathological remission (PCR), tertiary lymphoid structure (TLS) maturation and expression and clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC) receiving neoadjuvant chemoimmunotherapy. Totally 80 patients with resectable NSCLC (stage IB-IIIB) receiving neoadjuvant chemoimmunotherapy were analyzed. We used the Kaplan-Meier method to plot survival curves and the log-rank test to compare differences. Among all patients included, 45 patients (56.25%) achieved major pathological response (MPR), including 30 patients (37.50%) with PCR. The proportion of patients diagnosed with stage IB, II, IIIA and IIIB was 1.25%, 10.00%, 52.50% and 36.25%, respectively. We divided patients into PCR group and non-PCR group respectively according to whether they achieved PCR. We found that patients achieving PCR had significantly improved disease-free survival (DFS) (mDFS: NR vs. 20.24 months, P = .020). TLS expression was low in 43 cases (53.75%) and high in 37 cases (46.25%). TLS maturation was low in 55 cases (68.75%) and high in 25 cases (31.25%). The DFS of patients with TLS high-maturation (34.07 vs. 22.30 months, P = .024) and TLS high-expression (34.07 vs. 22.30 months, P = .041) was significantly longer. In most subgroups, the PCR, TLS high-maturation and TLS high-expression group respectively achieved a better clinical outcome relative to the non-PCR, TLS low-maturation and TLS low-expression group. In patients with resectable NSCLC receiving neoadjuvant chemoimmunotherapy, the acquirement of PCR may predict better DFS. In addition, high expression and maturation of TLS may be prognostic factors.
The dynamic energy source of the Sun and the duplicity of the stellar energy production
Creators: name: Grandpierre, Attila
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Some possible ways of the energy production with fusion reactions in the Sun was explored theoretically in the first half of this century. Nowadays it is a standard view that the Sun produces its energy on a uniform level. I point out, that in the stellar and solar energy production a dynamic energy source is necessarily present behind the uniform one, and generates a direct connection between the core and the surface layers through tunnels.
description: 14 pages, gzipped postscript file, accepted for Proc. Sixth UN-ESA Workshop of Basic Space Science, ed. H. Haubold, 1998
The cathode tube effect: heavy quarks probing the Glasma in p-Pb collisions
Creators: name: Ruggieri, Marco
name: Das, Santosh K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We study the propagation of charm quarks in the early stage of high energy proton-lead collision, considering the interaction of these quarks with the evolving Glasma by means of the Wong equations. Neglecting quantum fluctuations at the initial time the Glasma is made of longitudinal fields, but the dynamics leads to a quick formation of transverse fields; we estimate such a formation time as $Δt\approx 0.1$ fm/c which is of the same order of the formation time of heavy quark pairs $t_\mathrm{formation}\approx 1/(2m)$. Limiting ourselves to the simple case of a static longitudinal geometry, we find that heavy quarks are accelerated by the strong transverse color fields in the early stage and this leads to a tilting of the $c-$quarks spectrum towards higher $p_T$ states. This average acceleration can be understood in terms of drag and diffusion of $c-$quarks in a hot medium and appears to be similar to the one felt by the electrons ejected by the electron cannon in a cathode tube: we dub this effect as {\it cathode tube effect}. The tilting of the spectrum affects the nuclear modification factor, $R_\mathrm{pPb}$, suppressing this below one at low $p_T$ and making it larger than one at intermediate $p_T$. We compute $R_\mathrm{pPb}(p_T)$ after the evolution of charm quarks in the gluon fields and we find that its shape is in qualitative agreement with the measurements of the same quantity for $D-$mesons in proton-lead collisions.
description: 9 pages, 5 figures. In V2: -) A new figure has been added, new Fig. 3. -) Parameters choice has been explained better. -) Discussion about the effect has been improved: now the reshape of the c-quarks spectrum due to the color fields has been reinterpreted as a diffusion in momentum space
Application of the $O(N)$-Hyperspherical Harmonics to the Study of the Continuum Limits of One-Dimensional $σ$-Models and to the Generation of High-Temperature Expansions in Higher Dimensions
Creators: name: Campostrini, Massimo
name: Cucchieri, Attilio
name: Mendes, Tereza
name: Pelissetto, Andrea
name: Rossi, Paolo
name: Sokal, Alan D.
name: Vicari, Ettore
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: In this talk we present the exact solution of the most general one-dimensional $O(N)$-invariant spin model taking values in the sphere $S^{N-1}$, with nearest-neighbour interactions, and we discuss the possible continuum limits. All these results are obtained using a high-temperature expansion in terms of hyperspherical harmonics. Applications in higher dimensions of the same technique are then discussed.
description: 59208 bytes uuencoded gzip'ed (expands to 135067 bytes Postscript); 4 pages including all figures; contribution to Lattice '95
On the notion of potential in quantum gravity
Creators: name: Kazakov, Kirill A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The problem of consistent definition of the quantum corrected gravitational field is considered in the framework of the $S$-matrix method. Gauge dependence of the one-particle-reducible part of the two-scalar-particle scattering amplitude, with the help of which the potential is usually defined, is investigated at the one-loop approximation. The $1/r^2$-terms in the potential, which are of zero order in the Planck constant $\hbar,$ are shown to be independent of the gauge parameter weighting the gauge condition in the action. However, the $1/r^3$-terms, proportional to $\hbar,$ describing the first proper quantum correction, are proved to be gauge-dependent. With the help of the Slavnov identities, their dependence on the weighting parameter is calculated explicitly. The reason the gauge dependence originates from is briefly discussed.
description: LaTex 2.09, 16 pages, 5 ps figures
GENDERGA OID AUDIT O'TKAZISH METODOLOGIYASI
Creators: name: Saidboboyeva, Bibioliya
Publisher: name: Zenodo
Year: 2024

description: Genderga oid audit o‘tkazish tushunchasi va uning huquqiy asoslariga bugungi kunda ijtimoiy hayotning asosiy sohalarida gender tengligiga erishish hamda uni jamiyatda ta’minlash kun tartibiga qo‘yilayotgan asosiy maqsadlardan biriga aylanib borayotganligini ko‘rish mumkin.
Improving the topological charge density operator on the lattice
Creators: name: Christou, C.
name: Di Giacomo, A.
name: Panagopoulos, H.
name: Vicari, E.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We analyze the properties of a class of improved lattice topological charge density operators, constructed by a smearing-like procedure. By optimizing the choice of the parameters introduced in their definition, we find operators having (i) a much better statistical behavior as estimators of the topological charge density on the lattice, i.e. much less noisy; (ii) a multiplicative renormalization much closer to one; (iii) a large suppression of the perturbative tail in the corresponding lattice topological susceptibility.
description: 4 pages, to be published in the Proceedings of Lattice 95, uuencoded postscript file
Schwinger terms in two-dimensional gravitation and Kallen's method
Creators: name: Bertlmann, R. A.
name: Kohlprath, E.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We evaluate the gravitational Schwinger terms for the specific two-dimensional model of Weyl fermions in a gravitational background field using a technique introduced by Kallen and find a relation which connects the Schwinger terms with the linearized gravitational anomalies.
Safety and immunogenicity of a heterologous booster with an RBD virus-like particle vaccine following two- or three-dose inactivated COVID-19 vaccine
Creators: name: Yong, Xiaolan
name: Liu, Jun
name: Zeng, Ying
name: Nie, Jing
name: Cui, Xuelian
name: Wang, Tao
name: Wang, Yilin
name: Chen, Yiyong
name: Kang, Wei
name: Yang, Zhonghua
name: Liu, Yan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: LYB001 is an innovative recombinant SARS-CoV-2 vaccine that displays a repetitive array of the spike glycoprotein’s receptor-binding domain (RBD) on a virus-like particle (VLP) vector to boost the immune system, produced using Covalink plug-and-display protein binding technology. LYB001’s safety and immunogenicity were assessed in 119 participants receiving a booster with (1) 30 μg LYB001 (I-I-30 L) or CoronaVac (I-I-C), (2) 60 μg LYB001 (I-I-60 L) or CoronaVac in a ratio of 2:1 after two-dose primary series of inactivated COVID-19 vaccine, and (3) 30 μg LYB001 (I-I-I-30 L) after three-dose inactivated COVID-19 vaccine. A well-tolerated reactogenicity profile was observed for LYB001 as a heterologous booster, with adverse reactions being predominantly mild in severity and transient. LYB001 elicited a substantial increase in terms of the neutralizing antibody response against prototype SARS-CoV-2 28 days after booster, with GMT (95%CI) of 1237.8 (747.2, 2050.6), 554.3 (374.6, 820.2), 181.9 (107.6, 307.6), and 1200.2 (831.5, 1732.3) in the I-I-30 L, I-I-60 L, I-I-C, and I-I-I-30 L groups, respectively. LYB001 also elicited a cross-neutralizing antibody response against the BA.4/5 strain, dominant during the study period, with GMT of 201.1 (102.7, 393.7), 63.0 (35.1, 113.1), 29.2 (16.9, 50.3), and 115.3 (63.9, 208.1) in the I-I-30 L, I-I-60 L, I-I-C, and I-I-I-30 L groups, respectively, at 28 days after booster. Additionally, RBD-specific IFN-γ, IL-2, IL-4 secreting T cells dramatically increased at 14 days after a single LYB001 booster. Our data confirmed the favorable safety and immunogenicity profile of LYB001 and supported the continued clinical development of this promising candidate that utilizes the VLP platform to provide protection against COVID-19.
Additional file 1: of Carriage of antibiotic-resistant Gram-negative bacteria after discontinuation of selective decontamination of the digestive tract (SDD) or selective oropharyngeal decontamination (SOD)
Creators: name: E. De Jonge
name: R. De Wilde
name: N. Juffermans
name: E. Oostdijk
name: A. Bernards
name: E. Van Essen
name: E. Kuijper
name: C. Visser
name: J. Kesecioglu
name: M. Bonten
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Table S1. Colonization with resistant Gram-negative bacteria at ICU discharge. (DOCX 17 kb)
Chiral condensate, susceptibilities, critical coupling and indices in QED$_4$
Creators: name: Azcoiti, V.
name: Di Carlo, G.
name: Galante, A.
name: Grillo, A. F.
name: Laliena, V.
name: Piedrafita, C.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We measure chiral susceptibilities in the Coulomb phase of noncompact QED$_4$ in $8^4, 10^4$ and $12^4$ lattices. The MFA approach allows simulations in the chiral limit which are therefore free from arbitrary mass extrapolations. Using the critical couplings extracted from these calculations, we study the critical behaviour of the chiral condensate, which we find in disagreement with the predictions of logarithmically improved scalar Mean Field theory.
description: 7 pages, 4 figures, LaTeX file and postscript figures appended, talk presented at Lattice '95
Construction of lattices for communications and security
Creators: name: Yan, Yanfei
Publisher: name: Imperial College London
Year: 2014

description: In this thesis, we propose a new class of lattices based on polar codes, namely polar lattices. Polar lattices enjoy explicit construction and provable goodness for the additive white Gaussian noise (AWGN) channel, \textit{i.e.}, they are \emph{AWGN-good} lattices, in the sense that the error probability (for infinite lattice coding) vanishes for any fixed volume-to-noise ratio (VNR) greater than $2\pi e$. Our construction is based on the multilevel approach of Forney \textit{et al.}, where on each level we construct a capacity-achieving polar code. We show the component polar codes are naturally nested, thereby fulfilling the requirement of the multilevel lattice construction. We present a more precise analysis of the VNR of the resultant lattice, which is upper-bounded in terms of the flatness factor and the capacity losses of the component codes. The proposed polar lattices are efficiently decodable by using multi-stage decoding. Design examples are presented to demonstrate the superior performance of polar lattices. However, there is no infinite lattice coding in the practical applications. We need to apply the power constraint on the polar lattices which generates the polar lattice codes. We prove polar lattice codes can achieve the capacity $\frac{1}{2}\log(1+\SNR)$ of the power-constrained AWGN channel with a novel shaping scheme. The main idea is that by implementing the lattice Gaussian distribution over the AWGN-good polar lattices, the maximum error-free transmission rate of the resultant coding scheme can be arbitrarily close to the capacity $\frac{1}{2}\log(1+\SNR)$. The shaping technique is based on discrete lattice Gaussian distribution, which leads to a binary asymmetric channel at each level for the multilevel lattice codes. Then it is straightforward to employ multilevel asymmetric polar codes which is a combination of polar lossless source coding and polar channel coding. The construction of polar codes for an asymmetric channel can be converted to that for a related symmetric channel, and it turns out that this symmetric channel is equivalent to an minimum mean-square error (MMSE) scaled $\Lambda/\Lambda'$ channel in lattice coding in terms of polarization, which eventually simplifies our coding design. Finally, we investigate the application of polar lattices in physical layer security. Polar lattice codes are proved to be able to achieve the strong secrecy capacity of the Mod-$\Lambda$ AWGN wiretap channel. The Mod-$\Lambda$ assumption was due to the fact that a practical shaping scheme aiming to achieve the optimum shaping gain was missing. In this thesis, we use our shaping scheme and extend polar lattice coding to the Gaussian wiretap channel. By employing the polar coding technique for asymmetric channels, we manage to construct an AWGN-good lattice and a secrecy-good lattice with optimal shaping simultaneously. Then we prove the resultant wiretap coding scheme can achieve the strong secrecy capacity for the Gaussian wiretap channel.
Chemical tools to validate N-myristoyltransferase as a new target in cancer therapy
Creators: name: Thinon, Emmanuelle
Publisher: name: Imperial College London
Year: 2013

description: N-myristoylation is the irreversible attachment of myristate, a C14-lipid, to the N-terminal glycine of a protein. This modification is catalysed by myristoyl CoA: protein N-myristoyltransferase (NMT). N-myristoylation has been shown to be essential for the viability and survival of many organisms, including plants, parasites and humans. In humans, two isoforms of NMT, HsNMT1 and HsNMT2, were identified and it was suggested that they possess overlapping substrate specificities. NMT was identified as a potential chemotherapeutic target for cancer 18 years ago and subsequent studies showed that NMT was up-regulated in several cancers. However, no study demonstrated that NMT could be a therapeutic target in cancer therapy. In this study, chemically-tagged analogues of myristic acid were synthesised and applied to cancer cell lines to study protein N-myristoylation. The analogues can be incorporated on the N-terminal glycine of NMT substrates. The tag in this system enables a second extremely selective and high-yielding chemical ligation to any reporter of choice, for instance a dye label. Visualisation of the tagged proteins was carried out by in-gel fluorescence. Tagged-proteins could also be enriched and analysed by mass spectrometry-based proteomics. The combination of chemical proteomics with a potent NMT inhibitor is described in this thesis as a new method to identify with high confidence a large number of NMT substrates. In search for novel and potent human NMT inhibitors, various compounds were tested using an in vitro assay and a cell cytotoxicity assay. On-target inhibition of NMT in cells was assessed by in-gel fluorescence using analogues of myristic acid. The best inhibitors were employed as tools to study NMT inhibition in cancer cells. Western blot analysis and flow cytometry were used to assess the phenotype of NMT inhibition. Finally, the substrate specificity of the two isoforms was studied in cells using siRNAs against HsNMT1 or HsNMT2, and in vitro by screening for activity libraries of peptides against NMT1 or NMT2.
Gauge models in modified triplectic quantization
Creators: name: Geyer, Bodo
name: Lavrov, Petr M.
name: Moshin, Pavel Yu.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We apply the modified triplectic formalism for quantizing several popular gauge models - non-abelian antisymmetric tensor field model, W2-gravity and two-dimensional gravity with dynamical torsion. The explicit solutions are obtained for the generating equations of the quantum action and the gauge-fixing functional. Using these solutions we construct the vacuum functional and obtain the corresponding transformations of the extended BRST symmetry.
description: 20 pages, LATEX; Appendix added, some changes of text and addition of references
MOESM2 of Neck circumference and its association with cardiometabolic risk factors: a systematic review and meta-analysis
Creators: name: Ataie-Jafari, Asal
name: Nazli Namazi
name: Djalalinia, Shirin
name: Pouria Chaghamirzayi
name: Abdar, Mohammad
name: Zadehe, Sara
name: Asayesh, Hamid
name: Zarei, Maryam
name: Armita Gorabi
name: Mansourian, Morteza
name: Qorbani, Mostafa
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Figure S2. Forest plot of high neck circumference specificity for predicting metabolic syndrome in E) male, F) female, G) children, H) adult population.
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00064
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00064, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Regulatory B cells in seasonal allergic rhinitis and the influence of grass pollen immunotherapy
Creators: name: Charlesworth, James
Publisher: name: Imperial College London
Year: 2014

description: Introduction: Interleukin (IL)-10-producing B cells (Bregs) regulate immune responses in autoimmune disease; however their role in allergy is unclear. Allergen exposure in predisposed atopic individuals results in the induction of IgE-secreting B cells, crucial in the immunopathophysiology of allergic rhinitis. Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment for allergic rhinitis. AIT results in long-term clinical and immunological tolerance; however, whether Bregs contribute towards AIT-induced tolerance remains unclear. Hypotheses: 1. In vitro induced IL-10-producing B cells regulate allergen-driven Th2 inflammation, 2. Bregs are present in fewer numbers in seasonal grass pollen allergic (SAR) individuals compared with healthy controls, which is restored during AIT. Methods: B cells were isolated and subjected to flow cytometry to detect surface markers and IL-10 capacity following CpG stimulation. FluoroSpot, ELISA or qPCR were used to confirm IL-10. Suppression of T cell proliferation (by CFSE) and cytokine production (by ELISA) were carried out in co-cultures. Regulatory B cells in SAR (n=14), AIT (n=18) and healthy (n=14) donors were compared. Nasal allergen challenge (NAC) was carried out, with blood taken pre and post challenge for flow cytometry. Results: CpG significantly enhanced proportions of Bregs, with enrichment particularly within CD24hiCD27+, CD5hi, PD-L1+ and CD24hiCD38hi populations. Bregs suppressed both polyclonally- and grass pollen allergen-stimulated T cells. Ex vivo, proportions of IL-10+ B cells from SAR and healthy donors matched, but were significantly greater amongst AIT donors (particularly sublingual immunotherapy - SLIT) compared to SAR. Following NAC, proportions of B cells within CD24hiCD38hi, CD5hi, CD24hiCD27hi and CD25+ subsets were significantly increased amongst non-allergic and AIT groups, but not amongst SAR donors. Conclusion: Bregs are capable of suppressing allergen induced, Th2-driven inflammation in vitro and may be involved in the induction of tolerance during allergen immunotherapy in vivo, particularly following SLIT.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Cart. 167 (11 H 67), f. 0057r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0057r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0057r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Tricritical point in strongly coupled U(1) gauge theory with fermions and scalars
Creators: name: Franzki, W.
name: Jersák, J.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We investigate the tricritical point in the lattice fermion--gauge--scalar model with U(1) gauge symmetry. In the vicinity of this point, in the phase with the broken chiral symmetry, we observe the scaling behavior of the chiral condensate and of the masses of composite fermion and composite scalar, indicating the existence of an interesting continuum limit of the model at this point.
description: Contribution to Lattice 95, LaTeX file (4 pages), 5 ps-figures appended (uuencoded)
Oral history interview with Virginia Housholder, 2001
Publisher: name: Columbia University
Year: 2020

description: Early years: Born in Salem, Missouri; raised in Peoria Illinois; 1940 graduated Bradley Polytechnic Institute with degree in History; master's degree in Political Science at University of Wyoming; Career: 1942 intern at National Institute of Public Affairs; 1945 UN Relief and Rehabilitation Administration in Germany; 1947 UN Education, Scientific, and Cultural Organization (UNESCO) in Mexico City and Paris; 1950 State Department Office of International Development; 1966-1968: Program, Planning, and Budgeting (PPB) for State Department Public Health Service; 1968 management analyst at Pan American Health Organization (PAHO); 1977 UN Advisory Committee on Administrative and Budgetary Questions (UNACABQ); 1981-1985 UNESCO Advisory Committee; Themes: poor budget management and organization at UN advocate for reform; author of first report about State Department contributions to international organizations; highlights strong peacekeeping efforts by the UN; United Nations-US cooperation essential
Sindbis virus polyarthritis outbreak signalled by virus prevalence in the mosquito vectors
Creators: name: Lundström, Jan O.
name: Hesson, Jenny C.
name: Schäfer, Martina L.
name: Östman, Örjan
name: Semmler, Torsten
name: Bekaert, Michaël
name: Weidmann, Manfred
name: Lundkvist, Åke
name: Pfeffer, Martin
Publisher: name: Robert Koch-Institut
Year: 2019
Subjects: subject: Mosquitoes
subject: Viral vectors
subject: Flooding
subject: Sweden
subject: Vector-borne diseases
subject: Sindbis virus
subject: DNA sequence analysis
subject: Epidemiology
subject: 610 Medizin und Gesundheit

description: Polyarthritis and rash caused by Sindbis virus (SINV), was first recognised in northern Europe about 50 years ago and is known as Ockelbo disease in Sweden and Pogosta disease in Finland. This mosquito-borne virus occurs mainly in tropical and sub-tropical countries, and in northern Europe it is suggested to cause regularly reoccurring outbreaks. Here a seven-year cycle of SINV outbreaks has been referred to in scientific papers, although the hypothesis is based solely on reported human cases. In the search for a more objective outbreak signal, we evaluated mosquito abundance and SINV prevalence in vector mosquitoes from an endemic area in central Sweden. Vector mosquitoes collected in the River Dalälven floodplains during the years before, during, and after the hypothesised 2002 outbreak year were assayed for virus on cell culture. Obtained isolates were partially sequenced, and the nucleotide sequences analysed using Bayesian maximum clade credibility and median joining network analysis. Only one SINV strain was recovered in 2001, and 4 strains in 2003, while 15 strains were recovered in 2002 with significantly increased infection rates in both the enzootic and the bridge-vectors. In 2002, the Maximum Likelihood Estimated infection rates were 10.0/1000 in the enzootic vectors Culex torrentium/pipiens, and 0.62/1000 in the bridge-vector Aedes cinereus, compared to 4.9/1000 and 0.0/1000 in 2001 and 0.0/1000 and 0.32/1000 in 2003 Sequence analysis showed that all isolates belonged to the SINV genotype I (SINV-I). The genetic analysis revealed local maintenance of four SINV-I clades in the River Dalälven floodplains over the years. Our findings suggest that increased SINV-I prevalence in vector mosquitoes constitutes the most valuable outbreak marker for further scrutinising the hypothesized seven-year cycle of SINV-I outbreaks and the mechanisms behind.
Treatment-prognostication-adjustment a new therapeutic idea by analyzing T cell immune checkpoint in tumor microenvironment by algorithm: A bibliometric analysis
Creators: name: Ma, Shiwei
name: Wu, Xin
name: Wu, Zhongguang
name: Zhao, Qiangqiang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: To evaluate the temporal and spatial distribution of the knowledge network about tumor microenvironment and prognoses and explore new research hot spots and trends. Articles and reviews on tumor microenvironment and prognoses in the Web of Science journal from January 1999 to April 2022 were included. We used the CiteSpace and VOSviewer software to analyze the knowledge network composed of journals, institutions, countries, authors, and keywords. Frontiers in Immunology, Cancers, and Frontiers in Oncology have published more than 10% of articles in this field. China and the United States have contributed the most articles. Fudan University and Sun Yat-Sen University are the most active institutions. The authors in this field work closely; Zhang Wei and Douglas have made outstanding contributions. The three main research areas of tumor microenvironment and prognoses are microenvironment, prognosis, and immunotherapy. Until 2020, the main keywords were endothelial growth factor and adhesion. In the past three years, survival analysis, immune cell infiltration, and prediction model have been used. It can be seen that the focus in this field has shifted from tumor cell behavior and directly related molecules to prognosis prediction and non-tumor cells in the microenvironment. The future research trend may be to study the changes in the tumor microenvironment to predict the prognosis and guide the treatment. VOSviewer, CiteSpace, and Microsoft Excel 2019 were used to conduct a comprehensive visual analysis of the research on tumor environment and prognoses and provide valuable reference materials for researchers.
Non-BPS Branes in a Type I Orbifold
Creators: name: Eyras, E.
name: Panda, S.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyse the spectrum of non-BPS branes in the type I theory on the orbifold $T^4/{\cal I}_4$. We present a detailed analysis of the action of the worldsheet parity $Ω$ on the different D-brane boundary state sectors of type IIB on $T^4/{\cal I}_4$, using the covariant formulation. Using these results we derive the spectrum of branes in the type I orbifold. We find $\Z_2$- and $\Z$- charged non-BPS branes. A study of the stability of these branes in the type I orbifold is also presented. We find that the type I non-BPS D-particle and D-instanton remain stable in the orbifold. The D-particle carries no charge whereas the non-BPS D-instanton can carry twisted R-R charge.
description: 32 pages, LaTeX, no figures. Stability analysis has been corrected: the D-particle is found to be stable
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00471
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00471, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The functionality of a therapeutic antibody candidate restored by a single mutation from proline to threonine in the variable region
Creators: name: Hautiere, Marie
name: Maffucci, Irene
name: Costa, Narciso
name: Herbet, Amaury
name: Essono, Sosthene
name: Padiolleau-Lefevre, Séverine
name: Boquet, Didier
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Medicine
Pharmacology
Biological Sciences not elsewhere classified
Cancer

description: mAbs play an essential role in the therapeutic arsenal. Our laboratory has patented the Rendomab-B49 mAb targeting the endothelin B receptor (ETB). This G protein-coupled receptor plays a driving role in the progression of numerous cancers. We chimerized our mAb (xiRB49) to evaluate its preclinical therapeutic efficacy in different ETB+ tumor models with an antibody drug conjugate approach. As previously reported, the chimerization process of an antibody can alter its functionality. In this article, we present the chimerization of RB49. xiRB49 purified by Protein A remained perfectly soluble and did not aggregate, but it lost all its ability to recognize ETB. A detailed analysis of its variable region using IMGT tools allowed us to identify an unusual proline at position 125. In silico mAb modeling and in vitro experiments were performed for a better understanding of xiRB49 structure-function relationships. Our results show that the proline in position 125 on the heavy chain alters the xiRB49 CDR3 light chain conformation and its mutation to threonine allows complete functional recovery.
Gamorithm
Creators: name: Sipper, Moshe
name: Moore, Jason H.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Other Computer Science (cs.OH)
subject: FOS: Computer and information sciences

description: Examining games from a fresh perspective we present the idea of game-inspired and game-based algorithms, dubbed "gamorithms".
description: IEEE Transactions on Games, 2018