cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Filipino Customer’s Preferences of Online Marketing Channels
Creators: name: Landayan, Earl Vincent Z.
name: M., Cañares, Julia Isabelle
name: Samson, Hanz Christian
name: Samson, Martin Gabriel
Publisher: name: figshare
Year: 2022
Subjects: subject: 150505 Marketing Research Methodology
subject: FOS: Economics and business
subject: 150599 Marketing not elsewhere classified

description: Abstract  The world is transitioning from analog to digital, and marketing is everywhere. The usage of digital marketing, social media marketing, and online marketing is growing in parallel with technological advancement. Internet users are rapidly increasing, and digital marketing has benefited the most, because it is mostly dependent on the internet. Consumer buying behavior is changing, and they are more inclined to use digital marketing rather than traditional marketing. The goal of this study is to investigate the influence and experience of digital marketing and how significant it is for both consumers and marketers. This study begins with an introduction to digital marketing before highlighting the mediums of digital marketing, considering the distinction between traditional and digital marketing, as well as the benefits and disadvantages, as well as the expansion of digital marketing today.
Supplementary_Materials_(5) - MAGP2, a Component of Extracellular Matrix, Is Upregulated in Colorectal Cancer and Negatively Modulated by miR-200b-3p
Creators: name: Feifei, Wei
name: Hui, Guo
name: Ruiqiang, Zhao
name: Qunxiang, Jiang
name: Yu’an, Xie
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging
subject: Biochemistry

description: Supplementary_Materials_(5) for MAGP2, a Component of Extracellular Matrix, Is Upregulated in Colorectal Cancer and Negatively Modulated by miR-200b-3p by Wei Feifei, Guo Hui, Zhao Ruiqiang, Jiang Qunxiang and Xie Yu’an in Technology in Cancer Research & Treatment
Defining regulators of hematopoietic stem cell self-renewal to prevent and treat blood cancers.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Nicotine, the addictive compound in tobacco and electronic cigarettes, has been considered the safer alternative to tobacco. However, recent studies have begun to question this assumption and provide clear evidence of its harmful effects on cell functions. Specifically, nicotine has been shown to increase the number of blood stem cells, called hematopoietic stem cells (HSCs). HSCs are responsible for the daily formation of all blood and immune cells, and are essential for life. The number of HSCs must be tightly controlled because too many can lead to cancer, and too few can cause bone marrow failure. One way this is controlled is through the HSC's ability to make more of themselves through a process called self-renewal. I am interested in understanding how HSC self-renewal is normally regulated and how exposure to nicotine affects this unique property of HSCs. Ultimately, I hope to use the new insights gained from this study to develop strategies to more effectively and precisely treat and prevent blood cancers and tobacco-related diseases.
A Study of Environmental Awareness and Environmental Attitude of Pre-service Secondary School Teachers”
Creators: name: Chauhan, Ramesh Singh
Publisher: name: figshare
Year: 2022
Subjects: subject: 50203 Environmental Education and Extension
subject: FOS: Earth and related environmental sciences

description: “Environment is the representative of physical components of the earth where in man is an important factor affecting the environment.” -A. Goudie Our country has 15% of world population and has only 2.4% of land area available. Since we have enough land area to serve our population, we need to know the carrying capacity of our country. Among the carrying capacity there should be the availability of food, water, land, energy and lakes. The condition of these resources is becoming poor due to the loss of natural resources and pollution. These are the peoples who are totally concerned to their life. Industrial revolution is on its rapid rate in India and enjoys the 10th largest nation of the world. These industries produce gases, liquids and some solid form. Which is toxic and hazardous to our life? There is the degradation of the lands and natural calamities due the global warming. This fast deteriorating environment has posed serious threat to life and well being of the people of state. Since last two decades the global environment has become a matter of international concern. More and more people are becoming aware of the urgent need to understand the effects of man’s actions in and on his environment. That’s why Environment has come to occupy the top position in the agenda of all the governments- both developed and developing. The Himalaya is a unique heritage of mankind and it influences our civilization in a variety of ways. This proud full heritage of mankind is in danger due to indiscriminate exploitation and unplanned development. Industrial civilization and unplanned extraction of natural resources which ultimately creates a services which ultimately creates a serious challenge for the environment. Awareness, appreciation and undertaking of the environment are only first steps and do not necessarily lead to effective action. Environmental education should result in the knowledge desire and ability necessary to direct one’s conduct towards improving the quality of life. It should encourage teachers to environmentalism their teaching, stimulate them to engage in exploring their personal assumptions, values and feelings about society and the relationship to these in natural environment. Environmental education therefore must receive adequate importance in India right the primary level to higher education.
Additional file 1 of Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock
Creators: name: Pode-Shakked, Naomi
name: Ceschia, Giovanni
name: Rose, James E.
name: Goldstein, Stuart L.
name: Stanski, Natalja L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 1: Figures and Tables.
Diseases of the heart
Creators: name: Wyatt, Thomas D.
Publisher: name: University of Oregon
Year: 1925
Subjects: subject: Communicable Diseases
subject: Public Health
subject: Rheumatic Fever
subject: Typhoid Fever
subject: Diphtheria
subject: Tuberculosis
subject: Pneumonia, Bacterial
subject: heart health

description: Under this heading only the infectious diseases which are considered to have a direct relationship to heart involvement will be taken up. The diseases will be discussed in order of their frequency, including the following: Rheumatic Fever, Pneumonia, Typhoid, Diphtheria, and Tuberculosis.
Understanding how perinatal nicotine exposure influences immune establishment and function for life
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Nicotine is the compound responsible for tobacco and electronic cigarette’s addictive properties. Recent studies suggest that exposure to nicotine is harmful and has lasting effects on health. Specifically, nicotine exposure during pregnancy has lasting implications on the health and immunity of the fetus and causes increased susceptibility to diseases of the lungs and airways. Additionally, nicotine exposure during fetal development has been shown to increase inflammation and alter immune functions. Hematopoietic stem cells (HSCs) are responsible for the formation of all blood and immune cells, making them a plausible source for altered life-long immunity. I am interested in understanding how nicotine exposure during development affects HSCs and the immune cells they generate. Ultimately, I hope to use the new insights gained from this study to develop novel strategies to impede disease development and improve immune function in nicotine-exposed children.
Human murmuration: Group polarisation as compression in interaction-language dynamics captured by large language models
Creators: name: Durrheim, Kevin
name: Quayle, Michael
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: New technologies enable a social psychology that sees individuals and society as co-constitutive elements of a complex system. Using the metaphor of a murmuration—a loosely organized, locally responsive flock—this paper proposes a “science of movement” focused on trajectories of individual activity within evolving social interactions and language. We illustrate human murmuration by reviewing research on group polarization, showing how conversational joint action shapes opinion and identity. Language evolves in this process, becoming a tool for differentiation through strategic bias articulation. Polarization is understood as compression in the social information system— the medium of human murmuration. We explore how compression, bias and identity appear in large language models, reflecting the dynamic process of human thinking and activity. The paper concludes with a manifesto for social psychology, outlining directions for research that can leverage emerging meth?ods to realize the discipline’s potential in the age of complex systems and computational tools.
Spatial-, neighborhood- and healthcare system-related drivers of lung cancer treatment disparities
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the leading cause of cancer-related death for men and women in the United States. In 2019, it is projected that 228,150 Americans will be diagnosed and 142,670 will die from lung cancer. Smoking is the most common risk factor for lung cancer, contributing to 80%-90% of lung cancer deaths. In 2013, the U.S. Preventative Task Force began recommending lung cancer screening for people at high risk, which has resulted in an earlier stage diagnosis for many tobacco users. However, disparities in who receives screening and appropriate treatment for lung cancer have been observed across different racial/ethnic groups, among socioeconomically disadvantaged populations, and underserved rural populations. Favorable prognosis is highly dependent on a patient’s stage of diagnosis and receipt of proper treatment in a timely manner. California has a highly diverse population with more Hispanics, Asians, and American Indians than any other state, a combined nonwhite population that is the second highest of any state, and one of the highest poverty rates nationwide. The objective of this dissertation is to better understand the mechanisms of disparities in lung cancer patient’s receipt of proper treatment in California. Specifically, to identify factors that explain racial/ethnic disparities in receipt of proper care from three distinct domains: spatial proximity and accessibility of treatment facilities, racial composition and segregation of a patient’s neighborhood, and aspects of the patient-provider relationship within the healthcare system. Several population-based data sources will be used, including geocoded statewide cancer registry data linked with electronic health records from a large healthcare system in Northern California. The fellow will earn a Doctor of Philosophy in Epidemiology, with mentorship and planned training in geospatial analysis, minority health disparities, healthcare delivery, methods for explanation in causal inference, and use of electronic health records for observational research.
Developing a Novel Cell-free DNA Methylation Assay for Noninvasive Early Detection of Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the number one cause of cancer deaths in the world, but it can be cured if it is detected when tumors are small and have not spread. Unfortunately, lung cancer is not usually caught at this early stage, as small tumors such as these remain asymptomatic. Because of this, the survival rate for lung cancer as a whole is bleak. I am interested in developing new ways of detecting lung cancer earlier. An ideal early detection test would be (a) easily accessed by at-risk populations; (b) inexpensive; (c) accurate at detecting the presence of cancer; (d) noninvasive. All of us have short fragments of free-floating DNA in our bloodstreams that is released when cells naturally die and turn over. This DNA is referred to as cell-free DNA, or cfDNA. In a person who has cancer, some fraction of the total cfDNA originates from the tumor cells. Because tumors differ from healthy cells by the presence of mutations, tumor-derived cfDNA can be detected by looking for the presence of these mutations, and my lab has excelled at using these mutations to detect cancer noninvasively. In addition to mutations, tumor cells also differ from healthy cells in the ways they control their genes, a term that can be collectively called their 'epigenome.' The cell-free DNA epigenome has not been extensively studied as a biomarker for cancer early detection, and I am interested in developing a new method that uses the epigenome and mutations together to help detect lung cancers earlier.
supplemental_information - When OK is Not OK: Public Concern About White Nationalism in the U.S. Military
Creators: name: Ralston, Robert
name: Motta, Matthew
name: Spindel, Jennifer
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: Sociology
subject: FOS: Sociology

description: supplemental_information for When OK is Not OK: Public Concern About White Nationalism in the U.S. Military by Robert Ralston, Matthew Motta and Jennifer Spindel in Armed Forces & Society
A Strategic Framework for Supporting Open Access Monographs: Library Acquisitions Principles and Assessment Criteria
Creators: name: Booth, Emma
Publisher: name: Zenodo
Year: 2024
Subjects: open access
libraries
acquisitions

description: This presentation was part of the National Acquistions Group (NAG)'s Webinar Week in November 2024.The webinar shared information about an Operational Project from the University of Manchester Library that was designed to support the implementation of UKRI’s Open Access Policy for Long-Form Research Publications by developing a strategic framework for evaluating and supporting alternative funding models for Open Access monographs. This project aimed to ensure a purposeful and holistic approach to supporting ‘non-BPC’ models for funding OA monographs and their associated infrastructure, such as open metadata, and open dissemination and preservation systems, in order to connect the Library’s altruistic aspirations in support of Open Research and bibliodiversity with realistic and affordable strategic actions.

The focus of the presentation is on the outputs of Work Package 4 of the project: the Library’s ‘Strategic Framework for the Acquisition of OA Monographs,’ and its ‘Assessment Criteria for Supporting Collective Funding Models for OA Monographs and Open Infrastructure.’
Tables_3_to_6_online_appendix_CA – Supplemental material for Preserving Organizational Trust During Disruption
Creators: name: Gustafsson, Stefanie
name: Gillespie, Nicole
name: Searle, Rosalind
name: Hailey, Veronica Hope
name: Dietz, Graham
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, Tables_3_to_6_online_appendix_CA for Preserving Organizational Trust During Disruption by Stefanie Gustafsson, Nicole Gillespie, Rosalind Searle, Veronica Hope Hailey and Graham Dietz in Organization Studies
Supplemental_Table_S1 - Assessing Performance in Simulated Cleft Palate Repair Using a Novel Video Recording Setup
Creators: name: Podolsky, Dale J.
name: Fisher, David M.
name: Riff, Karen W. Wong
name: Zuker, Ronald M.
name: Drake, James M.
name: Forrest, Christopher R.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental_Table_S1 for Assessing Performance in Simulated Cleft Palate Repair Using a Novel Video Recording Setup by Dale J. Podolsky, David M. Fisher, Karen W. Wong Riff, Ronald M. Zuker, James M. Drake and Christopher R. Forrest in The Cleft Palate-Craniofacial Journal
Depression_Interview_Guide_7.16.2015_copy – Supplemental material for Stumbling Into Adulthood: Learning From Depression While Growing Up
Creators: name: Grob, Rachel
name: Schlesinger, Mark
name: Wise, Meg
name: Pandhi, Nancy
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Depression_Interview_Guide_7.16.2015_copy for Stumbling Into Adulthood: Learning From Depression While Growing Up by Rachel Grob, Mark Schlesinger and Nancy Pandhi in Qualitative Health Research
Appendix_1_Cost_categories_with_unit_prices_ – Supplemental material for Economic evaluation of a combined screening and stepped-care treatment program targeting psychological distress in patients with metastatic colorectal cancer: A cluster randomized controlled trial
Creators: name: Alili, Mohamed El
name: Schuurhuizen, Claudia S.E.W
name: Braamse, Annemarie M.J.
name: Aartjan T.F. Beekman
name: Mecheline H. Van Der Linden
name: Konings, Inge R.
name: Dekker, Joost
name: Bosmans, Judith E.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, Appendix_1_Cost_categories_with_unit_prices_ for Economic evaluation of a combined screening and stepped-care treatment program targeting psychological distress in patients with metastatic colorectal cancer: A cluster randomized controlled trial by Mohamed El Alili, Claudia S.E.W Schuurhuizen, Annemarie M.J. Braamse, Aartjan T.F. Beekman, Mecheline H. van der Linden, Inge R. Konings, Joost Dekker and Judith E. Bosmans in Palliative Medicine
Supplemental Material, Appendix_C_MAR_2020 - Comprehension Scores Among Young Neurotypical Children and Children With Autism: Paper and iPad® Storybooks
Creators: name: Marble-Flint, Karissa J.
name: Strattman, Kathy H.
name: Schommer-Aikins, Marlene A.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental Material, Appendix_C_MAR_2020 for Comprehension Scores Among Young Neurotypical Children and Children With Autism: Paper and iPad® Storybooks by Karissa J. Marble-Flint, Kathy H. Strattman and Marlene A. Schommer-Aikins in Journal of Special Education Technology
Supplementary_file – Supplemental material for “Body as a Machine”: How Adolescents With Sickle Cell Disease Construct Their Fatigue Experiences
Creators: name: Poku, Brenda Agyeiwaa
name: Ann-Louise Caress
name: Kirk, Susan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Supplementary_file for “Body as a Machine”: How Adolescents With Sickle Cell Disease Construct Their Fatigue Experiences by Brenda Agyeiwaa Poku, Ann-Louise Caress and Susan Kirk in Qualitative Health Research
Additional file 1 of Accuracy and uncertainty analysis of reduced time point imaging effect on time-integrated activity for 177Lu-DOTATATE PRRT in patients and clinically realistic simulations
Creators: name: Peterson, Avery B.
name: Mirando, David M.
name: Dewaraja, Yuni K.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Virology

description: Additional file 1. Description: Document containing Figs. S1–S5 referred to in the manuscript. Figures are labeled with descriptive captions within the document.
Gestational E-Cigarette Exposure, Transgenerational Asthma, and the Germ Cell Epigenetic Memory
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: There has been a sharp rise in vaping, largely the result of the perception among users that vaping is essentially harmless because it does not contain smoke. The result is increased exposure of developing fetuses to potential harm not just from nicotine, but also from the flavorings in the inhaled vapors. Thus far, there has been little few systematic investigations on the potential adverse health effects of vaping. Our preliminary data in animals show that the effects of nicotine can have harmful effects to subsequent generations of offspring, even though they are never exposed to nicotine. In a well-established animal model, we exposed pregnant dams to nicotine, and found that not only did their offspring develop asthma at a significantly greater rate compared to controls who were naïve to nicotine, but the subsequent generation of offspring were at significantly increased risk as well, despite never having been exposed to nicotine at all. These data led us to wonder whether exposure to vaping via e-cigarettes (e-cigs) might produce the same adverse health effects as well. Here we propose to address questions that naturally arise from these provocative data: Can adverse effects of nicotine delivered by e-cigs impact subsequent generations? What is the role of flavorings in e-cigs? How do e-cigs impact the epigenome of germ cells (eggs and sperm)? How does that influence the development of lung cells (which differentiate from germ cells)? Are they normal, or abnormal? Our studies will address these questions using established models and experienced collaborators. Specifically, we propose to investigate whether vaping effects can be transmitted across generations, and determine the relative impact of inhaled nicotine and flavorings. Furthermore, we will determine the effects of vaping on germ cell viability and epigenetic memory. Our investigation will advance the understanding of how adverse effects of vaping are transmitted to future generations, and will not just inform public policy makers, but will arm them with objective evidence as they work to protect our society and our offspring from the harmful effects of vaping.
Portrayal Characters in Historical Drama: An Analytical and Critical Study
Creators: name: Adway, Abdallah
Publisher: name: figshare
Year: 2022
Subjects: Drama

description: This study seeks to research the portrayal of the historical characters in historical drama, to understand how the Arab and Islamic historical drama deals with these characters through its artistic and dramatic treatments. It aims to explore how historical characters are portrayed as well as to discover the formation of mental images about them in the historical drama that deals with sensitive characters on the religious and social levels. The study used the descriptive analytical method to understand and criticism the reality of historical drama. The study concluded that the historical drama should choose suitable actors whose dramatic background suits historical characters with social and religious sensitivity, such as the characters of the Sahaba and scholars. The dramatic aspect and the performance should not be the only consideration as this is reflected on the mental images that the viewers have about the historical character, so the viewer will see the historical character in the image of the actor whenever they see him/her in another series or movie, hence we must stress the importance of paying attention to the simulation of historical legal characters, and not leaving it up to the discretion of drama producers. Also, portraying the characters requires a link between the historical legacy of the character represented and simulating them and relying on correct information in the dialogue, on the other hand, However, in the absence of it, it is possible to rely on some correct information and maintain a positive image of the character in what depends on the imagination of drama in which sensitive characters are not represented.
Additional file 2 of Predictors of readmission in a medical department of a tertiary university hospital in the Philippines
Creators: name: Balane, Janika Adrienne L.
name: Yap, Celina Daia DG.
name: Villanueva, Cary Amiel G.
name: Palileo-Villanueva, Lia Aileen M.
name: Tamondong-Lachica, Diana R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 2.
Do E-Cigarettes Increase Risk for Sudden Death? Focus on the QT Interval
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The risk of sudden death from tobacco cigarette (TC) smoking is largely independent of smoking burden, and reverts to that of a non-smoker soon after smoking cessation. These observations have led to the hypothesis that smoking-related sudden death is a direct toxic effect of constituent(s) in TC smoke, rather than a consequence of progressive coronary artery disease. Although controversial, electronic cigarettes (ECs) are perceived by many as a safer alternative to lethal TCs. Toxic constituents in EC emissions are orders of magnitude lower than in TC smoke – that is, except for nicotine; comparable plasma nicotine levels are achievable in EC users and TC smokers. Mechanisms of sudden death from smoking TCs are uncertain, but TCs are known to increase adrenaline levels and to change how electrical impulses are conducted in the heart – both risk factors for ventricular arrhythmias. Importantly, in single heart cells, nicotine has been shown to directly alter the electrical impulses in a way that could potentially lead to abnormal heart rhythms. These changes can be detected on the ECG in humans by measuring a segment called the "QT interval." TC smokers are reported to have prolongation of the QT interval on the ECG, indicative of abnormal electrical conduction, and a risk factor for sudden death. In studies in mice, exposure to emissions from ECs have also been reported to significantly increase the QT interval. Interestingly, in this rodent model, QT prolongation was triggered by the solvents in EC emissions, in the absence of nicotine. It is unknown if chronic EC users, like chronic TC smokers, have abnormal electrical conduction. Further, if present, it is unknown if abnormal electrical conduction is attributable to the nicotine, or the non-nicotine constituents in EC emissions. Our central hypothesis is that EC use is associated with abnormal electrical conduction in the heart detectable on the ECG, and that this effect is mediated by the nicotine, not non-nicotine constituents in EC emissions. This hypothesis will be tested in humans using a rigorous crossover design, including ECs with nicotine and without nicotine, and the nicotine inhaler. EC-mediated QT prolongation in humans, if present, is a potential game changer. It would be expected to significantly influence regulations of ECs, and to alter the public’s perception that ECs are harmless.
MSJ917925_supplemental_figure_2 – Supplemental material for Clinical outcomes in patients who discontinue natalizumab therapy after 2 years in the Tysabri® Observational Program (TOP)
Creators: name: Butzkueven, Helmut
name: Trojano, Maria
name: Kappos, Ludwig
name: Spelman, Tim
name: Wiendl, Heinz
name: Rosales, Karen
name: Su, Ray
name: Licata, Stephanie
name: Ho, Pei-Ran
name: Campbell, Nolan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Aged Health Care

description: Supplemental material, MSJ917925_supplemental_figure_2 for Clinical outcomes in patients who discontinue natalizumab therapy after 2 years in the Tysabri® Observational Program (TOP) by Helmut Butzkueven, Maria Trojano, Ludwig Kappos, Tim Spelman, Heinz Wiendl, Karen Rosales, Ray Su, Stephanie Licata, Pei-Ran Ho and Nolan Campbell in Multiple Sclerosis Journal
Implications of stress-induced LPAR4 expression in lung and pancreatic cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: In 2018, lung and pancreatic cancer accounted for approximately 200,000 cancer-related deaths in the United States. A common risk factor for these two cancers is cigarette smoking, which can account for ~80% of lung and ~30% of pancreatic cancers. Although most lung and pancreatic cancers are initially responsive to therapy, these tumors eventually stop responding, allowing them to grow and spread. In order to make tumors more sensitive to therapy and for the effects of therapy to remain effective for longer, it is critical to understand the molecular pathways cancer cells use to evade the effects of therapy. My project focuses on a protein located on the surface of some cancer cells named lysophosphatidic acid receptor 4 (LPAR4). Lung and pancreatic cancer patients with high levels of LPAR4 show shorter survival compared with patients who have low LPAR4 levels. Interestingly, LPAR4 is only detected when the cancer cells are challenged by unfavorable growth conditions, such as poor access to nutrients or treatment with cancer therapy. Once cancer cells gain LPAR4, they become more aggressive, more likely to spread or metastasize, and they are able to ignore the effects of therapy. These findings suggest that targeting LPAR4 might represent a new way to sensitize lung and pancreatic cancers to the effects of therapy. The first goal of my project is to better define how LPAR4 contributes to lung and pancreatic cancer progression. To do this, I will ask how cancer cells turn on LPAR4 as a way to cope with stress, and I will investigate how they take advantage of LPAR4 to become drug resistant. My second goal is to develop and test new anti-cancer strategies targeting LPAR4 as a new way to halt tumor progression and sensitize tumor cells to the effects of therapy. By understanding the functions of LPAR4 in lung and pancreatic cancer cells, my project should identify new therapies for these two cancer types with strong links to cigarette smoking.
Supplemental Material, jm.17.0556-File003 - When Less Is More: How Mindset Influences Consumers’ Responses to Products with Reduced Negative Attributes
Creators: name: Wong, Vincent Chi
name: Su, Lei
name: Lam, Howard Pong-Yuen
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, jm.17.0556-File003 for When Less Is More: How Mindset Influences Consumers’ Responses to Products with Reduced Negative Attributes by Vincent Chi Wong, Lei Su and Howard Pong-Yuen Lam in Journal of Marketing
Targeting nuclear receptors for the treatment of Pancreatic cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Pancreatic cancer is one of those cancers whose survival rate has not improved significantly over last 40 years. Despite the relatively low incidence rate, it has the highest mortality rate among all the cancers. Of particular concern, pancreatic cancer is the only cancer with increasing mortality. Currently, only surgery remains the best chance of cure when detected early, as there are no therapies available to effectively treat this disease. To make condition even worse, even the early identified localized tumors are not operable in number of occasions. On the other end, patients who initially respond to the currently existing gold-standard chemotherapy, often develop resistance and do not respond to the treatment and die due to recurrent disease. These currently existing challenges requires the need for identification of therapeutic options that can efficiently cure this disease in advanced stage, or the development of techniques or tools that can detect this disease at a very early benign stage, along with the measures to prevent the progression of early stage disease to inoperable advanced stages. To offer one possible solution for treatment of pancreatic cancer, our lab proposes to target the “seed” of the cancer, i.e., the cancer stem cells by inhibiting proteins unique to such cells. Our lab have already identified a number of proteins that are unique to the pancreatic cancer stem cells. The outcome of our currently proposed study will reveal if targeting cancer stem cells can prevent the growth and spread of invasive pancreatic cancer to prolong the survival of the pancreatic cancer patients.
DS_10.1177_0363546520914632 – Supplemental material for Predictive Modeling to Determine Functional Outcomes After Arthroscopic Rotator Cuff Repair
Creators: name: Frangiamore, Salvatore
name: Dornan, Grant J.
name: Horan, Marilee P.
name: Mannava, Sandeep
name: Fritz, Erik M.
name: Zaamin B. Hussain
name: Moatshe, Gilbert
name: Godin, Jonathan A.
name: Pogorzelski, Jonas
name: Millett, Peter J.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, DS_10.1177_0363546520914632 for Predictive Modeling to Determine Functional Outcomes After Arthroscopic Rotator Cuff Repair by Salvatore Frangiamore, Grant J. Dornan, Marilee P. Horan, Sandeep Mannava, Erik M. Fritz, Zaamin B. Hussain, Gilbert Moatshe, Jonathan A. Godin, Jonas Pogorzelski and Peter J. Millett in The American Journal of Sports Medicine
Predicting cell-cell interactions in the tumor microenvironment for non-small cell lung carcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Heavy tobacco intake from cigarette smoking and second hand smoke greatly increases people’s chance of being diagnosed with lung cancer. Once people are diagnosed with lung cancer, they have approximately 50% chance of survival within the next five years. Although there are drugs available to treat lung cancer, such as chemotherapy and target treatment, there is still a chance the treatment will not work. To develop more precise and accurate treatment options, we need to better understand genetically what is causing drug resistance. Specifically, how do cancer cells interact with other types of cells in the lung to continue growth and evade drugs? Current studies show that cancer cells interact with surrounding immune cells to turn off their functions, so specific immune cells will not attack the cancer cells. Within the suite of immune cells, some are activated when they are assisting cancer cells and dormant otherwise. There are also many more cell types surrounding the cancer cells, such as blood and connective tissue cells, that also exist in different activated states. We hypothesize that all the surrounding cells in their various states communicate with each other to assist cancer cells with growth. To test this, we obtained data containing measurements of genetic activity in each cell type surrounding the lung cancer cells on a single cell level from a publicly available database. This allows us to peek into the genetic behavior of active and dormant cells from various cell types while they were present near cancer cells. With this data, we will first develop a machine learning algorithm to predict what communication interactions are occurring between the different states of cell types in lung cancer. This will provide insight into what cell behaviors are triggered in the different cell types. Next, we will match existing US Food and Drug Administration (FDA)-approved drugs to the interactions to suggest potential drug combinations that can be used to treat tobacco-related lung disease.
Supplemental Material, Appendix - Knowing Kids Makes a Huge Difference, Part I: Exploring the Principal–Student Relationship
Creators: name: Kudlats, Jamie
name: Brown, Kathleen M.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education

description: Supplemental Material, Appendix for Knowing Kids Makes a Huge Difference, Part I: Exploring the Principal–Student Relationship by Jamie Kudlats and Kathleen M. Brown in Journal of School Leadership
Total Synthesis of Strictosidine, a Precursor to Vinblastine
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the leading cause of cancer related deaths in California and the United States each year. The statistics for are astounding. Almost 160,000 Americans and 12,000 Californians die from lung cancer each year and, within five years of diagnosis, 82% of patients pass away. The link between smoking tobacco and lung cancer is well established and almost all lung cancer cases result from tobacco use. Unfortunately, most lung cancer diagnoses are not treatable by surgery, so chemotherapy has remained the preferred method of treatment. Therefore, it is critical to provide rapid and cost-effective access to lung cancer medications. Vinblastine and vincristine are two frontline anti-cancer therapeutics used to treat multiple cancers, including lung cancer. The industrial production of both of these drugs still relies on isolation from their natural plant source via an expensive and source-dependent process. Thus, vinblastine and vincristine remain some of the most expensive small molecule, off-patent chemotherapeutics on the market. Vinblastine and vincristine could be affordable with an efficient method of production; however, a viable alternative has not been developed. Toward the development of a new and efficient means to access vinblastine and vincristine, I propose to prepare secologanin and strictosidine. These compounds are Nature’s precursors to vinblastine and vincristine. It is envisioned that these studies will lay the foundation for future studies directed toward the conversion of strictosidine to vinblastine and vincristine using enzymes. Thus, the proposed studies would represent a significant milestone toward a scalable and affordable means for the chemoenzymatic production of vinblastine and vincristine.
DS_10.1177_0022034520920577 – Supplemental material for Niche Specific Microbiota-Dependent and Independent Bone Loss around Dental Implants and Teeth
Creators: name: O. Heyman
name: Y. Horev
name: N. Koren
name: O. Barel
name: I. Aizenbud
name: Y. Aizenbud
name: M. Brandwein
name: L. Shapira
name: A.H. Hovav
name: A. Wilensky
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, DS_10.1177_0022034520920577 for Niche Specific Microbiota-Dependent and Independent Bone Loss around Dental Implants and Teeth by O. Heyman, Y. Horev, N. Koren, O. Barel, I. Aizenbud, Y. Aizenbud, M. Brandwein, L. Shapira, A.H. Hovav and A. Wilensky in Journal of Dental Research
Strategic Growth Council Supplements
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: This project provides UCOP with $200,000 from the Strategic Growth Council to award ten additional supplements of $20,000 to California Climate Action Seed and Matching Grant awardees to enhance community engagement efforts that support collaborative approaches to ensure genuine multi-institution and community/end-user engagement. Additionally, this grant provides $50,000 for UCOP to develop a community engagement in climate action platform, furnishing researchers with a suite of useful tools and resources to enhance community engagement in climate action research across the system and the state. The Community-Engaged S/Hero Award Supplements will be awarded based on assessment of: (1) community engagement methods and techniques and the specific roles of all participants throughout the process; (2) the integration of community/end-user knowledge, research expertise, and access to communities, facilities, resources, data, and equipment; (3) emphasis on reciprocal knowledge exchange, solution-oriented alternatives, and the communication of research analysis and findings in ways that can be understood by communities and/or end users. UCOP will stand up and staff an R&I Community Engagement in Climate Action Team made up of a member of the Steering Committee of the UC-wide Community Engagement Network, a member of the UC Global Climate Leadership Council, a member of Agriculture and Natural Resources Community Engagement leadership, a member of UC Health Community Engagement leadership and the advisory members from the Community-Engaged S/Hero awardees and others. This group will advise on and contribute to the Community Engagement in Climate Action Platform that will provide resources to enhance community engagement in climate action research across the system and the state. This platform would include relevant resources/guides for community-partnered scholarship and climate action. The Team will also host R&I Community Engagement in Climate Action Team monthly virtual gatherings addressing key elements of community and host an in-person gathering centered on community engagement in climate action research.
Supplemental Material, Interview_schedule.docx_paper_3 - Patient Feedback on a Warfarin Action Plan Used in a Local Australian Physician Practice Setting
Creators: name: Yiu, Angela W.P.
name: Bajorek, Beata V.
name: Lee, Vincent W.
name: Ng, Kingsley K.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, Interview_schedule.docx_paper_3 for Patient Feedback on a Warfarin Action Plan Used in a Local Australian Physician Practice Setting by Angela W.P. Yiu, Beata V. Bajorek, Vincent W. Lee and Kingsley K. Ng in Therapeutic Innovation & Regulatory Science
Additional file 1 of A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations
Creators: name: Stružinská, Ivana
name: Hájková, Nikola
name: Hojný, Jan
name: Krkavcová, Eva
name: Michálková, Romana
name: Dvořák, Jiří
name: Němejcová, Kristýna
name: Matěj, Radoslav
name: Laco, Jan
name: Drozenová, Jana
name: Fabian, Pavel
name: Hausnerová, Jitka
name: Méhes, Gábor
name: Škapa, Petr
name: Švajdler, Marián
name: Cibula, David
name: Frühauf, Filip
name: Bártů, Michaela Kendall
name: Dundr, Pavel
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Additional file 5 of Genomic signatures of local adaptation in recent invasive Aedes aegypti populations in California
Creators: name: Soudi, Shaghayegh
name: Crepeau, Marc
name: Collier, Travis C.
name: Lee, Yoosook
name: Cornel, Anthony J.
name: Lanzaro, Gregory C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Supplementary Figure 2. a. Heatmap indicating correlation among 25 topo-climate variables collected from ClimateNA. b. Principle component analysis of the topo-climate variables for 12 populations used for the association analysis, with the projection of the correlations on the first PCA plan. The full names of the topo-climate variables are available in supplementary table 2.
Juiparus batus subsp. batus
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Juiparus
Juiparus batus
Juiparus batus batus (linnaeus, 1758)

description: 15. Juiparus batus batus (Linnaeus, 1758)
 Cerambyx batus Linnaeus, 1758: 390.
 Material examinado: Caxias (Perímetro urbano), macho, 01.III.2006, M.J.G. Souza col.; (Reserva Ecológica Inhamum), fêmea, 18.VII.2005, J.J. Souza & M.M.B.G. Jesus Junior col.; (CESC/ UEMA), fêmea, 01-04.II.2006, F. Limeira-de-Oliveira col.
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 234, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
sj-pdf-1-ras-10.1177_0020852320921473 - Supplemental material for Quality of governance and political support in China, Japan, and South Korea
Creators: name: Yida Zhai
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-pdf-1-ras-10.1177_0020852320921473 for Quality of governance and political support in China, Japan, and South Korea by Yida Zhai in International Review of Administrative Sciences