cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genetic variants in mitochondrial sirtuins associated with brain tumor risk: a case–control study
Creators: name: Haq, Maria Fazal Ul
name: Hussain, Muhammad Zahid
name: Haris, Muhammad Shahbaz
name: Kayani, Mahmood Akhtar
name: Mahjabeen, Ishrat
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Previous studies on brain tumors have been performed on the nuclear genome, but limited studies have been reported on the mitochondrial genome. The mitochondrial sirtuin (SIRT3/SIRT4/SIRT5) has been mutated in different cancers. Limited studies have been performed on brain tumors. Isocitrate dehydrogenase (IDH) is an important marker, and polymorphism in the IDH gene has been reported to differentiate the brain tumor subtypes. The present study was designed to screen mitochondrial sirtuins and IDH polymorphisms in brain tumor patients. One thousand blood samples were collected (500 brain tumor patients and 500 controls). Two SNPs for each gene SIRT3 (rs12226697, rs570591), SIRT4 (rs184496260, 1925909), SIRT5 (rs2841522, rs2841523), and one SNP for IDH (rs11554137) was screened using Tetra-ARMS PCR. Logistic regression showed that the mutant genotype of selected SNPs was associated with increased disease incidence compared to wild type. Haplotype analysis and linkage disequilibrium (LD) showed a strong LD in brain tumor patients. Kaplan–Meier analysis showed that mutant allele frequency was found to be associated with a significant decrease in the survival of brain tumor patients. The present study showed that the mutant allele of selected mitochondrial sirtuins’ SNP was associated with increased brain tumor risk.
มุมมองของนักวิชาชีพต่อคุณสมบัติของนักออกแบบภายในรุ่นใหม่
Creators: name: สิริพร กอบนิธิกุลวงศ์
Publisher: name: Thammasat Printing House
Year: 2017
Subjects: คุณสมบัติของนักออกแบบภายใน
นักออกแบบภายในรุ่นใหม่
มุมมองของนักวิชาชีพออกแบบภายใน
วิชาชีพออกแบบภายใน
วิชาการออกแบบภายใน

description: Journal of Architectural/Planning Research and Studies, 14, 2, 15-30
Species Diversity and Some Ecological Aspects of Chironomus Bloodworm (Order Diptera, Family Chironomidae) in Khon Kaen University during Dry Season
Creators: name: Nisarat Tungpairojwong
Publisher: name: KKU Science Journal
Year: 2024
Subjects: Midge
Biology
Diversity
Standing
Water
Khon Kaen

description: KKU Science Journal, 52, 2, 199-218
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells
Creators: name: Beri, Joshua
name: Herring, Laura E
name: East, Michael P
name: Vaziri, Cyrus
name: Goldfarb, Dennis
name: Wilkerson, Emily M
name: McDonald, Ian M
name: Graves, Lee M
name: Grant, Gavin D
name: Cook, Jeanette Gowen
name: Gilbert, Thomas S K
name: Emanuele, Michael J
Publisher: name: Elsevier
Year: 2020

description: The maternal embryonic leucine zipper kinase (MELK) has been implicated in the regulation of cancer cell proliferation. RNAi-mediated MELK depletion impairs growth and causes G2/M arrest in numerous cancers, but the mechanisms underlying these effects are poorly understood. Furthermore, the MELK inhibitor OTSSP167 has recently been shown to have poor selectivity for MELK, complicating the use of this inhibitor as a tool compound to investigate MELK function. Here, using a cell-based proteomics technique called multiplexed kinase inhibitor beads/mass spectrometry (MIB/MS), we profiled the selectivity of two additional MELK inhibitors, NVS-MELK8a (8a) and HTH-01-091. Our results revealed that 8a is a highly selective MELK inhibitor, which we further used for functional studies. Resazurin and crystal violet assays indicated that 8a decreases triple-negative breast cancer cell viability, and immunoblotting revealed that impaired growth is due to perturbation of cell cycle progression rather than induction of apoptosis. Using double-thymidine synchronization and immunoblotting, we observed that MELK inhibition delays mitotic entry, which was associated with delayed activation of Aurora A, Aurora B, and cyclin-dependent kinase 1 (CDK1). Following this delay, cells entered and completed mitosis. Using live-cell microscopy of cells harboring fluorescent proliferating cell nuclear antigen, we confirmed that 8a significantly and dose-dependently lengthens G2 phase. Collectively, our results provide a rationale for using 8a as a tool compound for functional studies of MELK and indicate that MELK inhibition delays mitotic entry, likely via transient G2/M checkpoint activation.
Extraction and Antioxidant Activity of Bioactive Compounds from Marine Microalgae Tetraselmis gracilis BIMS-PP017
Creators: name: Sunthorn Chooluck
Publisher: name: KKU Science Journal
Year: 2024
Subjects: Marine Microalgae
Bioactive Compound
Antioxidant Activity
Anti-Tyrosinase Activity

description: KKU Science Journal, 52, 2, 219-234
Effects of Salt, Table Sugar and Honey on the Quality of Pickled Makoknam (Elaeocarpus hygrophilus Kurz.)
Creators: name: Supang Ruangchai
Publisher: name: KKU Science Journal
Year: 2024
Subjects: Makoknam
Salt
Table Sugar
Honey
Lactic Acid Bacteria

description: KKU Science Journal, 52, 2, 235-244
Anti-melanogenic Activity of Tecoma stans (L.) Juss. ex Kunth Flower Extract in B16F10 Melanoma Cell Line
Creators: name: Wuttipong Mahakham
Publisher: name: KKU Science Journal
Year: 2024
Subjects: Anti-melanogenesis
Anti-tyrosinase Activity
Melanocytes
Tecoma stans

description: KKU Science Journal, 52, 2, 245-261
Supplemental Material - Construction and Validation of a Novel Immune-Related Gene Pairs-Based Prognostic Model in Lung Adenocarcinoma
Creators: name: Liu, Yafeng
name: Zhou, Jiawei
name: Wu, Jing
name: Zhang, Xin
name: Guo, Jianqiang
name: Xing, Yingru
name: Xie, Jun
name: Bai, Ying
name: Hu, Dong
Publisher: name: SAGE Journals
Year: 2023
Subjects: Oncology and Carcinogenesis not elsewhere classified

description: Supplemental Material for Construction and Validation of a Novel Immune-Related Gene Pairs-Based Prognostic Model in Lung Adenocarcinoma by Yafeng Liu, Jiawei Zhou, Jing Wu, Xin Zhang, Jianqiang Guo, Yingru Xing, Jun Xie, Ying Bai, and Dong Hu in Cancer Control
Baseline anxiety-sensitivity to estradiol fluctuations predicts anxiety symptom response to transdermal estradiol treatment in perimenopausal women - A randomized clinical trial
Creators: name: Neely, Olivia
name: Rubinow, David R
name: Girdler, Susan S
name: Lozza-Fiacco, Serena
name: Schiller, Crystal
name: Gordon, Jennifer Lee
name: Kozik, Rachel Grace
name: Andersen, Elizabeth Helen
name: Munoz, Maria
Publisher: name: Elsevier
Year: 2022

description: BACKGROUND: The menopausal transition (perimenopause) is associated with an increased risk of major depression, characterized by anxiety and anhedonia phenotypes. Greater estradiol (E2) variability predicts the development of perimenopausal depression, especially within the context of stressful life events (SLEs). While transdermal E2 (TE2) reduces perimenopausal depressive symptoms, the mechanisms underlying TE2 efficacy and predictors of TE2 treatment response remain unknown. This study aimed at determining relationships between E2 fluctuations, mood symptoms, and physiologic stress-reactivity (cortisol and interleukin-6) and whether differences in mood-sensitivity to E2 fluctuations predict mood responses to TE2 treatment. METHODS: This randomized, double-blind, placebo-controlled trial investigated medically healthy women (46-60 years) in the early or late menopause transition. Baseline E2-sensitivity strength was calculated from eight weekly individual correlations between week-to-week E2 change and index week anxiety (State-Trait Anxiety Inventory) and anhedonia (Snaith-Hamilton Pleasure Scale). Women then received eight weeks of TE2 or transdermal placebo. RESULTS: Analyses included 73 women (active TE2 n = 35). Greater baseline E2 fluctuations predicted greater anhedonia (p = .002), particularly in women with more SLEs. Greater E2 fluctuations also predicted higher cortisol (p = .012) and blunted interleukin-6 (p = .02) stress-responses. Controlling for baseline symptoms, TE2 was associated with lower post-treatment anxiety (p < .001) and anhedonia (p < .001) versus placebo. However, the efficacy of TE2 for anxiety (p = .007) and also for somatic complaints (p = .05) was strongest in women with greater baseline E2 sensitivity strength. CONCLUSIONS: TE2 treatment reduced perimenopausal anxiety and anhedonia. The ability of baseline mood-sensitivity to E2 fluctuations to predict greater TE2 efficacy has implications for individualized treatment of perimenopausal anxiety disorders.
Additional file 3 of Perioperative, function, and positive surgical margin in extraperitoneal versus transperitoneal single port robot-assisted radical prostatectomy: a systematic review and meta-analysis
Creators: name: Jiang, Yu
name: Liu, Yang
name: Qin, Shize
name: Zhong, Shuting
name: Huang, Xiaohua
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 3. Assessment using funnel plots revealed no evidence of publication bias.
The Berbatek Project For Basque: Promoting A Less-Resourced Language Via Language Technology For Translation, Content Management And Learning
Creators: name: Leturia, Igor
name: Sarasola, Kepa
name: Arregi, Xabier
name: Ilarraza, Arantza Diaz De
name: Navas, Eva
name: Sainz, Iñaki
name: Pozo, Arantza Del
name: Baranda, David
name: Iturraspe, Urtza
Publisher: name: Zenodo
Year: 2018

description: Basque is both a minority language (only a small proportion of the population of the Basque Country speaks it) and also a less-resourced language. Fortunately, the Basque regional government is committed to its recovery, and has adopted policies for funding, among other things, language technologies, a field which a language aiming to survive cannot dispense with. BerbaTek was a 3-year (2009--2011) strategic research project on language, speech and multimedia technologies for Basque carried out by a consortium of five members, all prominent local organizations dedicated to research in the above-mentioned areas, and partially funded by the Departments for Industry and Culture of the Basque Government. Collaboration in BerbaTek allowed to carry out a great amount of both basic and applied research. In addition, various prototypes were developed to show the potential of integrating the developed technologies to the language industry sector.
sj-docx-3-psg-10.1177_22925503231184266 - Supplemental material for A Systematic Review of the Reporting Quality of Qualitative Research in Breast Plastic Surgery
Creators: name: Hircock, Caroline
name: Leveille, Cameron F
name: Chen, Jeffrey
name: Lin, Xue-Wei
name: Lansang, Rafael P
name: Kim, Patrick J
name: Huan, Peter W
name: Gallo, Lucas
name: Thoma, Achilles
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 110323
subject: Surgery

description: Supplemental material, sj-docx-3-psg-10.1177_22925503231184266 for A Systematic Review of the Reporting Quality of Qualitative Research in Breast Plastic Surgery by Caroline Hircock, Cameron F Leveille, Jeffrey Chen, Xue-Wei Lin, Rafael P Lansang, Patrick J Kim, Peter W Huan, Lucas Gallo and Achilles Thoma in Plastic Surgery
BeeToxAI: An artificial intelligence-based web app to assess acute toxicity of chemicals to honey bees
Creators: name: Alves, Vinicius M.
name: Kleinstreuer, Nicole
name: Moreira-Filho, Jose T.
name: Costa, Wesley S.
name: Muratov, Eugene N.
name: Braga, Rodolpho C.
name: Borba, Joyce V.V.B.
name: Lemos, Jade Milhomem
name: Neves, Bruno J.
name: Andrade, Carolina Horta
Publisher: name: Elsevier
Year: 2021

description: Chemically induced toxicity is the leading cause of recent extinction of honey bees. In this regard, we developed an innovative artificial intelligence-based web app (BeeToxAI) for assessing the acute toxicity of chemicals to Apis mellifera. Initially, we developed and externally validated QSAR models for classification (external set accuracy ~91%) through the combination of Random Forest and molecular fingerprints to predict the potential for chemicals to cause acute contact toxicity and acute oral toxicity to honey bees. Then, we developed and externally validated regression QSAR models ( R 2 = 0.75) using Feedforward Neural Networks (FNNs). Afterward, the best models were implemented in the publicly available BeeToxAI web app (http://beetoxai.labmol.com.br/ ). The outputs of BeeToxAI are: toxicity predictions with estimated confidence, applicability domain estimation, and color-coded maps of relative structure fragment contributions to toxicity. As an additional assessment of BeeToxAI performance, we collected an external set of pesticides with known bee toxicity that were not included in our modeling dataset. BeeToxAI classification models were able to predict four out of five pesticides correctly. The acute contact toxicity model correctly predicted all of the eight pesticides. Here we demonstrate that BeeToxAI can be used as a rapid new approach methodology for predicting acute toxicity of chemicals in honey bees.
sj-docx-1-spo-10.1177_17479541231186146 - Supplemental material for Wet bulb globe temperature variability and its implications on heat stress monitoring
Creators: name: Grundstein, Andrew
name: Cooper, Earl
name: Hosokawa, Yuri
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-spo-10.1177_17479541231186146 for Wet bulb globe temperature variability and its implications on heat stress monitoring by Andrew Grundstein, Earl Cooper and Yuri Hosokawa in International Journal of Sports Science & Coaching
66282: Letter: To Marion Scott.
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Includes 'To England - A Note', in Marion Scott's hand / glad that Scott's health has improved / hoping for warmer weather / discusses 'By the Bierside' by John Masefield and Ivor Gurney's setting of it to music / mentions 'For England' and 'February Day' / discusses possible titles: 'Songs Before Dawn' / gives Scott leave to make changes / includes alterations for the 'Preface' to the collected volume / changes for 'To Certain Comrades' / gives Scott leave to deal with punctuation and 'Carol' / working on another sonnet / mentions potential publishers, with Sidgwick and Jackson as the preferred option / a new lyric forming beginning 'Starlight in Water'. | File description(s):Envelope containing letter.
Includes 'To England - A Note', in Marion Scott's hand / glad that Scott's health has improved / hoping for warmer weather / discusses 'By the Bierside' by John Masefield and Ivor Gurney's setting of it to music / mentions 'For England' and 'February Day' / discusses possible titles: 'Songs Before Dawn' / gives Scott leave to make changes / includes alterations for the 'Preface' to the collected volume / changes for 'To Certain Comrades' / gives Scott leave to deal with punctuation and 'Carol' / working on another sonnet / mentions potential publishers, with Sidgwick and Jackson as the preferred option / a new lyric forming beginning 'Starlight in Water'.
Calibration Systems For The Supernemo Experiment
Creators: name: SALAZAR, Ramon
Publisher: name: Zenodo
Year: 2018

description: SuperNEMO is the successor of the NEMO-3 experiment and will search for the hypothetical process of 0νββ by combining tracking and calorimetric measurements. The SuperNEMO calorimeter consists of 712 optical modules made of scintillator blocks directly coupled to photomultiplier tubes. Radioactive 207
^{207}
Bi sources will be used to calibrate the energy scale of the calorimeter in dedicated calibration runs separated by a few weeks. In between these runs, a Light Injection (LI) system will monitor the stability of the calorimetric response to 1%. The LI system injects pulsed LED light into each scintillator block via optical fibers. A reference optical module is used to monitor the light level against a 241
^{241}
Am source. The details of the calibration and monitoring systems are presented.
Promoting access to justice: An exploration of teaching alternative dispute resolution in Australian clinical legal education
Creators: name: Weinberg, Jackie
Publisher: name: Monash University
Year: 2020
Subjects: subject: 180123 Litigation, Adjudication and Dispute Resolution
subject: FOS: Law
subject: 189999 Law and Legal Studies not elsewhere classified

description: This thesis explores alternative dispute resolution (ADR) teaching in Australian clinical legal education. In a university law clinic, clinical legal education teaches students the skills needed for legal practice. With ADR becoming increasingly dominant in Australian legal practice, clinic students need to become knowledgeable about ADR so as to better advise clients about cost effective options for resolving cases without resorting to litigation. This enhanced focus on ADR has a vital ancillary effect of advancing access to justice. This thesis makes recommendations about how dispute resolution teaching can be better incorporated into clinical legal education for enhanced access to justice.
sj-docx-1-ggm-10.1177_23337214231186460 – Supplemental material for Shared-Medical Appointment for Screening and Risk Assessment for Fall Prevention
Creators: name: Moran, Ryan
name: Ramirez, Michelle
name: Woods, Gina
name: Hofflich, Heather
name: Wing, MS, David
name: Nichols, Jeanne
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 110308
subject: Geriatrics and Gerontology

description: Supplemental material, sj-docx-1-ggm-10.1177_23337214231186460 for Shared-Medical Appointment for Screening and Risk Assessment for Fall Prevention by Ryan Moran, Michelle Ramirez, Gina Woods, Heather Hofflich, David Wing, MS and Jeanne Nichols in Gerontology and Geriatric Medicine
Blood Pressure and Incident Atrial Fibrillation in Older Patients Initiating Hemodialysis
Creators: name: Chang, Tara I-Hsin
name: Niu, Jingbo
name: Winkelmayer, Wolfgang C
name: Liu, Sai
name: Turakhia, Mintu P
name: Montez-Rath, Maria E
name: Airy, Medha
name: Flythe, Jennifer E
Publisher: name: Wolters Kluwer
Year: 2019

description: BACKGROUND AND OBJECTIVES: We examined the association of predialysis systolic and diastolic BP and intradialytic hypotension with incident atrial fibrillation in older patients initiating hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used the US Renal Data System linked to the records of a large dialysis provider to identify patients aged ≥67 years initiating hemodialysis between January 2006 and October 2011. We examined quarterly average predialysis systolic BP, diastolic BP, and proportion of sessions with intradialytic hypotension (i.e., nadir systolic BP <90 mm Hg). We applied an extended Cox model to compute adjusted hazard ratios (HRs) of each exposure with incident atrial fibrillation. RESULTS: Among 17,003 patients, 3785 developed atrial fibrillation. When comparing predialysis systolic BP to a fixed reference of 140 mm Hg, lower predialysis systolic BP was associated with a higher hazard of atrial fibrillation, whereas higher systolic BP was associated with a lower hazard of atrial fibrillation. When comparing across a range of systolic BP for two hypothetical patients with similar measured covariates, the association varied by mean systolic BP: at systolic BP 190 mm Hg, each 10 mm Hg lower systolic BP was associated with lower atrial fibrillation hazard (HR, 0.94; 95% confidence interval, 0.90 to 1.00), whereas at systolic BP 140 mm Hg, a 10 mm Hg lower systolic BP was associated with a higher atrial fibrillation hazard (HR, 1.12; 95% confidence interval, 1.10 to 1.14). Lower diastolic BP was associated with higher atrial fibrillation hazards. Intradialytic hypotension was weakly associated with atrial fibrillation. CONCLUSIONS: In this observational study of older patients initiating hemodialysis, lower predialysis systolic BP and diastolic BP were associated with higher incidence of atrial fibrillation.
sj-docx-1-gjh-10.1177_23970022231181142 – Supplemental material for Employer calling: Incidence and worker-level effects of on-call work in Germany
Creators: name: Borah, Melanie
name: Fackler, Daniel
name: Stegmaier, Jens
name: Weigt, Eva
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 150310
subject: Organisation and Management Theory

description: Supplemental material, sj-docx-1-gjh-10.1177_23970022231181142 for Employer calling: Incidence and worker-level effects of on-call work in Germany by Melanie Borah, Daniel Fackler, Jens Stegmaier and Eva Weigt in German Journal of Human Resource Management
sj-docx-1-aut-10.1177_13623613231180266 – Supplemental material for Patterns of equipment use for autistic children in multi-sensory environments: Time spent with sensory equipment varies by sensory profile and intellectual ability
Creators: name: Unwin, Katy L
name: Powell, Georgina
name: Price, Alice
name: Jones, Catherine RG
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 170199
subject: Psychology not elsewhere classified
classificationCode: 110319
subject: Psychiatry (incl. Psychotherapy)
classificationCode: 111799
subject: Public Health and Health Services not elsewhere classified
subject: Education
classificationCode: 130312
subject: Special Education and Disability

description: Supplemental material, sj-docx-1-aut-10.1177_13623613231180266 for Patterns of equipment use for autistic children in multi-sensory environments: Time spent with sensory equipment varies by sensory profile and intellectual ability by Katy L Unwin, Georgina Powell, Alice Price and Catherine RG Jones in Autism
sj-pdf-2-pmj-10.1177_02692163231186177 – Supplemental material for An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice: A systematic review
Creators: name: Rizvi, Farwa
name: Wilding, Helen Elizabeth
name: Rankin, Nicole M
name: Le Gautier, Roslyn
name: Gurren, Lorna
name: Sundararajan, Vijaya
name: Bellingham, Kylee
name: Chua, Joyce
name: Crawford, Gregory B
name: Nowak, Anna K
name: Le, Brian
name: Mitchell, Geoff
name: McLachlan, Sue-Anne
name: Sousa, Tanara Vieira
name: Hudson, Robyn
name: IJzerman, Maarten
name: Collins, Anna
name: Philip, Jennifer
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 110308
subject: Geriatrics and Gerontology
classificationCode: 111702
subject: Aged Health Care

description: Supplemental material, sj-pdf-2-pmj-10.1177_02692163231186177 for An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice: A systematic review by Farwa Rizvi, Helen Elizabeth Wilding, Nicole M Rankin, Roslyn Le Gautier, Lorna Gurren, Vijaya Sundararajan, Kylee Bellingham, Joyce Chua, Gregory B Crawford, Anna K Nowak, Brian Le, Geoff Mitchell, Sue-Anne McLachlan, Tanara Vieira Sousa, Robyn Hudson, Maarten IJzerman, Anna Collins and Jennifer Philip in Palliative Medicine
Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
Creators: name: Sun, Bo
name: Bloomquist, Cameron
name: Mi, Yu
name: Montgomery, Stephanie A.
name: Wagner, Kyle
name: Xia, Youli
name: Zhang, Tian
name: Qi, Yanfei
name: Yang, Feifei
name: Wang, Andrew Z.
Publisher: name: Wiley
Year: 2019

description: Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas or lacking the adequate residence time to prevent adhesions. Herein, the development of a biologically targeted photo-crosslinkable nanopatch (pCNP) is reported that can prevent postsurgical adhesion. It is demonstrated that pCNP can form a compact protective barrier over surfaces with exposed collagen IV. Using a rat parietal peritoneal excision adhesion model, it is showed that pCNP is highly effective and safe in preventing postsurgical adhesions. This work presents a novel approach to preventing peritoneal adhesion with nanomaterials.
sj-docx-1-rsq-10.1177_87568705231179939 – Supplemental material for Career Development in Rural Districts: Opportunities and Limitations Regarding Students With Disabilities
Creators: name: Schutz, Michele A.
name: Travers, Hilary E.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Education
classificationCode: 130312
subject: Special Education and Disability

description: Supplemental material, sj-docx-1-rsq-10.1177_87568705231179939 for Career Development in Rural Districts: Opportunities and Limitations Regarding Students With Disabilities by Michele A. Schutz and Hilary E. Travers in Rural Special Education Quarterly
Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Creators: name: Polkinghorne, Kevan R.
name: Conference Participants
name: Gallagher, Martin P.
name: Jadoul, Michel
name: Lindley, Elizabeth
name: Weiner, Daniel E.
name: Chang, Tara I.
name: Sarafidis, Pantelis A.
name: Winkelmayer, Wolfgang C.
name: Cheung, Michael
name: Wang, Angela Yee-Moon
name: Flythe, Jennifer E.
name: Madero, Magdalena
name: Unruh, Mark L.
Publisher: name: Elsevier
Year: 2020

description: Blood pressure (BP) and volume control are critical components of dialysis care and have substantial impacts on patient symptoms, quality of life, and cardiovascular complications. Yet, developing consensus best practices for BP and volume control have been challenging, given the absence of objective measures of extracellular volume status and the lack of high-quality evidence for many therapeutic interventions. In February of 2019, Kidney Disease: Improving Global Outcomes (KDIGO) held a Controversies Conference titled Blood Pressure and Volume Management in Dialysis to assess the current state of knowledge related to BP and volume management and identify opportunities to improve clinical and patient-reported outcomes among individuals receiving maintenance dialysis. Four major topics were addressed: BP measurement, BP targets, and pharmacologic management of suboptimal BP; dialysis prescriptions as they relate to BP and volume; extracellular volume assessment and management with a focus on technology-based solutions; and volume-related patient symptoms and experiences. The overarching theme resulting from presentations and discussions was that managing BP and volume in dialysis involves weighing multiple clinical factors and risk considerations as well as patient lifestyle and preferences, all within a narrow therapeutic window for avoiding acute or chronic volume-related complications. Striking this challenging balance requires individualizing the dialysis prescription by incorporating comorbid health conditions, treatment hemodynamic patterns, clinical judgment, and patient preferences into decision-making, all within local resource constraints.
Authoring Support For Controlled Language And Machine Translation: A Report From Practice
Creators: name: Siegel, Melanie
Publisher: name: Zenodo
Year: 2018

description: Automatic authoring support for controlled language on the one hand and machine translation on the other have previously been seen as two distinct tools in the text processing process. This paper describes methods for the close integration of both, resulting in better written documents as well as machine translation output of higher quality. The methods were implemented in an existing tool for automatic authoring support.
Brain functional connectivity analysis based on multi-graph fusion
Creators: name: Zhu, Xiaofeng
name: Peng, Ziwen
name: Ma, Junbo
name: Hu, Rongyao
name: Gan, Jiangzhang
name: Wu, Guorong
Publisher: name: Elsevier
Year: 2021

description: In this paper, we propose a framework for functional connectivity network (FCN) analysis, which conducts the brain disease diagnosis on the resting state functional magnetic resonance imaging (rs-fMRI) data, aiming at reducing the influence of the noise, the inter-subject variability, and the heterogeneity across subjects. To this end, our proposed framework investigates a multi-graph fusion method to explore both the common and the complementary information between two FCNs, i.e., a fully-connected FCN and a 1 nearest neighbor (1NN) FCN, whereas previous methods only focus on conducting FCN analysis from a single FCN. Specifically, our framework first conducts the graph fusion to produce the representation of the rs-fMRI data with high discriminative ability, and then employs the L1SVM to jointly conduct brain region selection and disease diagnosis. We further evaluate the effectiveness of the proposed framework on various data sets of the neuro-diseases, i.e., Fronto-Temporal Dementia (FTD), Obsessive-Compulsive Disorder (OCD), and Alzheimers Disease (AD). The experimental results demonstrate that the proposed framework achieves the best diagnosis performance via selecting reasonable brain regions for the classification tasks, compared to state-of-the-art FCN analysis methods.
Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study.
Creators: name: Drummond, M Bradley
name: Liu, Mark C
name: Wise, Robert A
name: Mock, Jason R
name: Burkes, Robert M
name: Sanders, Emily C
name: Hansel, Nadia N
name: Brown, Todd T
Publisher: name: COPD Foundation
Year: 2021

description: INTRODUCTION: Cathelicidin is a vitamin D-regulated, antimicrobial peptide involved in the innate immune response of the airways. Reduced plasma cathelicidin concentrations are independently associated with worse pulmonary outcomes in current and former smokers. This study aimed to determine whether oral vitamin D supplementation in vitamin D-deficient current smokers increases plasma and bronchoalveolar lavage (BAL) cathelicidin levels. METHODS: Vitamin D-deficient (25-hydroxy vitamin D [25-OH vitamin D] <20 ng/ml) smokers (n=17) underwent collection of plasma and BAL for cathelicidin and 25-OH vitamin D measurements before and after 8 weeks of oral supplementation with 50,000 IU vitamin D3 weekly. Differences between baseline and 8-week levels of cathelicidin and 25-OH vitamin D in blood and BAL were assessed along with correlations between serum 25-OH vitamin D, plasma cathelicidin, and BAL cathelicidin. RESULTS: At baseline, there was no correlation between BAL and plasma cathelicidin. There was a significant increase in 25-OH vitamin D (median 17.0 to 43.3 ng/mL, p<0.001) after 8 weeks of vitamin D supplementation. There was no change in plasma cathelicidin (p=0.86), BAL cathelicidin (p=0.31), or BAL 25-OH vitamin D (p=0.89). There was no correlation between serum 25-OH vitamin D and either BAL or plasma cathelicidin post-supplementation. CONCLUSIONS: Oral vitamin D supplementation, while increasing serum 25-OH vitamin D levels, does not increase plasma or BAL cathelicidin levels in vitamin D-deficient, active smokers. The lack of increased BAL cathelicidin may be explained by multiple factors related to dosing, smoking effects, or putative mechanisms of engagement. Future studies are needed to determine the effects of vitamin D supplementation on lung and blood functional activity.
L’ENTREPRISE 2.0 : ENTRE LA RESPONSABILITE SOCIALE ET LA DURABILITE SOCIALE
Creators: name: KARIM, Khaddouj
Publisher: name: Revue Economie, Gestion et Société
Year: 2016

description: La Responsabilité sociale des entreprises (RSE) est l'une des questions les plus stratégiques auxquelles sont confrontées les grandes entreprises aujourd'hui et notamment les entreprises qualifiées 2.0. Notre papier de recherche analyse le passage consacré de la notion de RSE à une nouvelle conception intégrée connue comme la durabilité et la responsabilité. L’entreprise 2.0 objet de notre recherche est qualifiée de structure qui utilise les outils du technologique et informatique du Web en vue d’améliorer sa performance. Notre recherche met en évidence le concept dynamique de responsabilité sociale et insiste sur la nécessité de promouvoir des approches et modèles de recherche dans ce domaine à travers le cas de l’entreprise 2.0.
description: Revue Economie, Gestion et Société, No 4 (2015)
Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome
Creators: name: McCravy, Matthew
name: Drummond, M. Bradley
name: Mock, Jason R.
name: Norton, Dustin L.
name: Carson, Shannon S.
name: Ceppe, Agathe
name: Vincent, Benjamin G.
name: Dang, Hong
name: Doerschuk, Claire M.
name: Tune, Miriya K.
name: Hagan, Robert S.
name: Devlin, Thomas
Publisher: name: Springer Nature
Year: 2020

description: BackgroundFoxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation from mechanical ventilation, have a higher percentage of Tregs amongst CD4+ T cells in either airway, bronchoalveolar lavage (BAL) or peripheral blood samples.MethodsWe prospectively enrolled patients with ARDS requiring mechanical ventilation and collected serial samples, the first within 72 h of ARDS diagnosis (day 0) and the second 48-96 h later (day 3). We analyzed immune cell populations and cytokines in BAL, tracheal aspirates and peripheral blood, as well as cytokines in plasma, obtained at the time of bronchoscopy. The study cohort was divided into fast resolvers (FR; n=8) and slow resolvers (SR; n=5), based on the median number of days until first extubation for all participants (n=13). The primary measure was the percentage of CD4+ T cells that were Tregs.ResultsThe BAL of FR contained more Tregs than SR. This finding did not extend to Tregs in tracheal aspirates or blood. BAL Tregs expressed more of the full-length FOXP3 than a splice variant missing exon 2 compared to Tregs in simultaneously obtained peripheral blood.ConclusionTregs are present in the bronchoalveolar space during ARDS. A greater percentage of CD4+ cells were Tregs in the BAL of FR than SR. Tregs may play a role in the resolution of ARDS, and enhancing their numbers or functions may be a therapeutic target.
Les Technologies de l’Information et de la Communication appliquées à l’Enseignement : ENQUÊTES À PROPOS DES PRATIQUES DANS L’ENSEIGNEMENT UNIVERSITAIRE ET LA FORMATION PROFESSIONNELLE AU MAROC
Creators: name: Bouyzem, Meriem
name: Al Meriouh, Youssef
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Enseignement supérieur, Formation professionnelle, Maroc, TICE.

description: Le système de l’enseignement marocain peut aussi être situé dans la phase de modification selon le modèle SAMR : les étudiants sont assez familiarisés avec l’utilisation de différentes applications et sont, presque, capables d’apprendre grâce à la technologie, notamment grâce aux nombreux tutoriels vidéos disponibles en ligne. Cependant il existe une catégorie d’étudiants dont les conditions de vie sont difficiles et qui ne disposent d’aucune technologie et donc la généralisation de l’utilisation des TIC en dehors des classes constituera une exclusion pour elle, à moins que le système envisage des solutions pour les équiper des technologies nécessaires.
description: Revue Economie, Gestion et Société, No 4 (2015)
Integration Of Machine Translation In On-Line Multilingual Applications: Domain Adaptation
Creators: name: Mirela-Ştefania Duma
name: Vertan, Cristina
Publisher: name: Zenodo
Year: 2018

description: Large amounts of bilingual corpora are used in the training process of statistical

machine translation systems. Usually a general domain is used as the training corpus. When the system is tested using data from the same domain, the obtained

results are satisfactory, but if the test set belongs to a different domain, the trans-

lation quality decreases. This is due to insufficient lexical coverage, wrong choice

in case of polysemous words, and differences in discourse style between the two

domains. Thus, the need to adapt the system is an ongoing research task in ma-

chine translation. Some challenges in performing domain adaptation are to decide

which part of the system requires adaptation and to choose what method needs to

be applied. In this paper, we used language model interpolation as a domain adaptation method and proved that it is a fast state of the art method that can be used in

building adapted translation systems even when sparse domain specific material

is available (i.e. especially in the case of low-resourced language pairs). The best

improvement was of 15 bleu points over the baseline system.
C-H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C-H Bond
Creators: name: Knowles, Robert R.
name: Toa, Zi S. D.
name: Zhu, Qilei
name: Troian-Gautier, Ludovic
name: Alexanian, Erik J.
name: Morton, Carla M.
name: Ripberger, Hunter
Publisher: name: American Chemical Society (ACS)
Year: 2019

description: The direct, site-selective alkylation of unactivated C(sp3)-H bonds in organic substrates is a long-standing goal in synthetic chemistry. General approaches to the activation of strong C-H bonds include radical-mediated processes involving highly reactive intermediates, such as heteroatom-centered radicals. Herein, we describe a catalytic, intermolecular C-H alkylation that circumvents such reactive species via a new elementary step for C-H cleavage involving multisite-proton-coupled electron transfer (multisite-PCET). Mechanistic studies indicate that the reaction is catalyzed by a noncovalent complex formed between an iridium(III) photocatalyst and a monobasic phosphate base. The C-H alkylation proceeds efficiently using diverse hydrocarbons and complex molecules as the limiting reagent and represents a new approach to the catalytic functionalization of unactivated C(sp3)-H bonds.
Principaux déterminants des investissements directs étrangers au Maroc (1980-2012)
Creators: name: AZEROUAL, Mohamed
name: CHERKAOUI, Mouna
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Déterminants des IDE, capital humain, ouverture commerciale, crédit intérieur, taille du marché, taux de change, formation brute du capital fixe, infrastructures, salaire minimum interprofessionnel garanti, qualité des institutions.

description: Cet article analyse empiriquement les principaux déterminants des investissements directs étrangers (IDE) au Maroc en utilisant le test de cointégration et l’estimation du Vector Error Correction Model(VECM) sur la période 1980-2012. Les principaux résultats démontrent qu’à long terme, les variables : capital humain, infrastructures, SMIG, FBCF et taux de change réel ont tous des signes attendus et constituent les principaux déterminants des IDE au Maroc. En revanche, l’ouverture commerciale, la qualité des institutions et le crédit intérieur fourni au secteur privé, affichent des signes négatifs non conformes à ce qui est attendu au moment où la variable PIB réel qui mesure la taille du marché intérieur apparait non significative.
description: Revue Economie, Gestion et Société, No 4 (2015)
Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes
Creators: name: Venditto, Nicholas J.
name: Nicewicz, David A.
Publisher: name: American Chemical Society (ACS)
Year: 2020

description: Nucleophilic aromatic substitution (SNAr) is a common method for arene functionalization; however, reactions of this type are typically limited to electron-deficient aromatic halides. Herein, we describe a mild, metal-free, cation-radical accelerated nucleophilic aromatic substitution (CRA-SNAr) using a potent, highly oxidizing acridinium photoredox catalyst. Selective substitution of arene C-O bonds on a wide array of aryl ether substrates was shown with a variety of primary amine nucleophiles. Mechanistic evidence is also presented that supports the proposed CRA-SNAr pathway.
Multilingual Knowledge In Aligned Wiktionary And Omegawiki For Translation Applications
Creators: name: Matuschek, Michael
name: Meyer, Christian M.
name: Gurevych, Iryna
Publisher: name: Zenodo
Year: 2018

description: Multilingual lexical-semantic resources play an important role in translation applications. However, multilingual resources with sufficient quality and coverage

are rare as the effort of manually constructing such a resource is substantial. In recent years, the emergence of Web 2.0 has opened new possibilities for constructing

large-scale lexical-semantic resources. We identified Wiktionary and OmegaWiki

as two important multilingual initiatives where a community of users (“crowd”)

collaboratively edits and refines the lexical information. They seem especially appropriate in the multilingual domain as users from all languages and cultures can

easily contribute. However, despite their advantages such as open access and coverage of multiple languages, these resources have hardly been systematically investigated and utilized until now. Therefore, the goals of our contribution are threefold: (1) We analyze how these resources emerged and characterize their content

and structure; (2) We propose an alignment at the word sense level to exploit the

complementary information contained in both resources for increased coverage;

(3) We describe a mapping of the resources to a standardized, unified model (uby-lmf) thus creating a large freely available multilingual resource designed for easy

integration into applications such as machine translation or computer-aided translation environments.
Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults
Creators: name: Wu, Aozhou
name: Matsushita, Kunihiro
name: Heiss, Gerardo
name: Selvin, Elizabeth
name: Hoogeveen, Ron C.
name: Ballantyne, Christie M.
name: Tanaka, Hirofumi
name: Meyer, Michelle L.
name: Liu, Shuiqing
name: Cheng, Susan
name: Kim, Esther D.
Publisher: name: Public Library of Science (PLoS)
Year: 2019

description: BACKGROUND: Arterial stiffness independently predicts cardiovascular disease. However, few studies have evaluated the associations of central and peripheral pulse wave velocity (PWV) with biomarkers of both myocardial stress (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin-T [hs-cTnT]) among persons without cardiac disease. METHODS: We examined 3,348 participants (67-90 years) without prevalent cardiac disease in the Atherosclerosis Risk in Communities (ARIC) Study (2011-13). The cross-sectional associations of PWV quartiles for central arterial segments (carotid-femoral, heart-carotid, heart-femoral) and peripheral artery (femoral-ankle) with NT-proBNP and hs-cTnT were evaluated accounting for potential confounders. RESULTS: Most PWV measures demonstrated J- or U-shaped associations with the two cardiac biomarkers. The highest (Q4) vs. second lowest (Q2) quartile of central PWV measures (carotid-femoral, heart-carotid, heart-femoral PWV) were associated with higher levels of NT-proBNP independently of demographic characteristics. The associations were less evident for hs-cTnT. These associations were attenuated after adjusting for traditional cardiovascular risk factors, but the heart-carotid PWV-NT-proBNP relationship remained borderline significant (difference in log-NT-proBNP = 0.08 [-0.01, 0.17] in Q4 vs. Q2, p = 0.07). Peripheral PWV demonstrated inverse associations. Higher values of NT-proBNP were seen in the lowest vs. second lowest quartile of all PWV measures. CONCLUSIONS: Central stiffness measures showed stronger associations with cardiac biomarkers (particularly NT-proBNP) than peripheral measures among older adults without cardiac disease. Our findings are consistent with the concept of ventricular-vascular coupling and suggest that central rather than peripheral arterial hemodynamics are more closely related to myocardial stress rather than damage.
Trade liberalization of harbor sector in Morocco: From the managing to governance rules
Creators: name: BABOUNIA, AZIZ
name: EL IMRANI, OUAIL
Publisher: name: Revue Economie, Gestion et Société
Year: 2015
Subjects: Libéralisation, style de gouvernance, trafic portuaire, le coût de passage portuaire.

description: Les changements économiques et sociaux vécus par le Maroc depuis des années et qui sont motivés par les besoins de développement interne et par des engagements liés à des accords de libre-échange (ALE) et aussi par le nouveau contexte de la mondialisation du commerce, qui a forcé les autorités publiques à un engagement pour le déjeuner un nouveau processus de mise à niveau de l'économie du pays tout entier. Dans ce contexte, le Maroc a pris l'engagement de mettre en oeuvre des mesures sensibles pour contribuer au renforcement et à la modernisation des infrastructures du pays. La libéralisation du secteur portuaire avait regardé depuis 2006, de cette manière. Les objectifs de cette réforme sont variés car ils répondent à la fois la nécessité d'élever le niveau de compétitivité des ports marocains avec internationale 'des services d'adaptation port d'approvisionnement de standards à la demande de trafic et de le rendre accessible à l'économie de les opérateurs, les entreprises nationales, des infrastructures, de l'équipement efficace améliorer leur propre compétitivité. Le tout, comme il est affirmé, vise à atteindre un objectif plus important: La performance des places portuaires (carrés). Donc, quand nous parlons du port marocain secteur un certain nombre de rapports sont impératives: • Le Maroc dans plus de 3500 km de la côte. • Les frontières Algérie- Maroc sont fermées. • Les frontières Maroc -Mauritanie ne proposent pas un grand potentiel en termes de transactions commerciales. • Presque tout le commerce extérieur passe en transit par les ports (roulements): environ 98% des échanges extérieurs (étrangers). • Des investissements très importants ont été réservés au cours des vingt dernières années du siècle dernier pour améliorer et diversifier les installations portuaires. La libéralisation du secteur portuaire a également surgir un objectif clé qui est l'externalisation des services qui ont été historiquement prêté sous contrôle administratif. le soutien des activités du port par les participants privés doit rester un moyen à la disposition des pouvoirs publics pour réaliser les objectifs de l'intérêt général. Les principaux secteurs que nous allons essayer de gérer, en examinant les expériences marocaines, dans le travail de cette recherche sont: • L'histoire de la réforme du secteur portuaire au Maroc. • La mise en oeuvre de la réforme du port au Maroc. • Les implications du nouveau style de gouvernance sur les systèmes financiers, administratifs et sur le commerce extérieur. • Les limites de la situation actuelle. • Les perspectives d'évolution du mode actuel de gouvernance liés à port marocain
description: Revue Economie, Gestion et Société, No 4 (2015)