The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI): Incidence and First-Episode Case–Control Programme
Creators: name: Gayer-Anderson, Charlotte
name: Jongsma, Hannah E.
name: Di Forti, Marta
name: Quattrone, Diego
name: Velthorst, Eva
name: De Haan, Lieuwe
name: Selten, Jean-Paul
name: Szöke, Andrei
name: Llorca, Pierre-Michel
name: Tortelli, Andrea
name: Arango, Celso
name: Bobes, Julio
name: Bernardo, Miguel
name: Sanjuán, Julio
name: Santos, José Luis
name: Arrojo, Manuel
name: Parellada, Mara
name: Tarricone, Ilaria
name: Berardi, Domenico
name: Ruggeri, Mirella
name: Lasalvia, Antonio
name: Ferraro, Laura
name: La Cascia, Caterina
name: La Barbera, Daniele
name: Menezes, Paulo Rossi
name: Del-Ben, Cristina Marta
name: Rutten, Bart P.
name: Van Os, Jim
name: Jones, Peter B.
name: Murray, Robin M.
name: Kirkbride, James B.
name: Morgan, Craig
name: Hubbard, Kathryn
name: Beards, Stephanie
name: Reininghaus, Ulrich
name: Tripoli, Giada
name: Stilo, Simona A.
name: Roldán, Laura
name: López, Gonzalo
name: Matteis, Mario
name: Rapado, Marta
name: González, Emiliano
name: Martínez, Covadonga
name: Cuadrado, Pedro
name: Solano, José Juan Rodríguez
name: Carracedo, Angel
name: Costas, Javier
name: Bernardo, Enrique García
name: Sánchez, Emilio
name: Olmeda, Ma Soledad
name: Cabrera, Bibiana
name: Lorente-Rovira, Esther
name: Garcia-Portilla, Paz
name: Jiménez-López, Estela
name: Franke, Nathalie
name: Van Dam, Daniella
name: Termorshuizen, Fabian
name: Van Der Ven, Elsje
name: Messchaart, Elles
name: Leboyer, Marion
name: Schürhoff, Franck
name: Baudin, Grégoire
name: Ferchiou, Aziz
name: Pignon, Baptiste
name: Jamain, Stéphane
name: Richard, Jean-Romain
name: Charpeaud, Thomas
name: Tronche, Anne-Marie
name: Frijda, Flora
name: Sideli, Lucia
name: Seminerio, Fabio
name: Sartorio, Crocettarachele
name: Marrazzo, Giovanna
name: Loureiro, Camila Marcelino
name: Shuhama, Rosana
name: Tosato, Sarah
name: Bonetto, Chiara
name: Cristofalo, Doriana
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Study Protocols and Samples
Case–control
Environment–environment interactions
EU-GEI
First-episode psychosis
Gene–environment interactions
Incidence

description: Funder: FP7 Ideas: European Research Council; doi: http://dx.doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2010-241909
description: Abstract: Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.