cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Manipulation and characterization of thin-film interfacial chemistry: sol-gel deposition and single molecule tracking experiments
Creators: name: Barhoum, Moussa
Publisher: name: University of Utah
Year: 2012
Subjects: Interfacial processes
Lipid bilayers
Magneto-optical studies
Single molecule fluorescence
Sol-gel
Thin-deposition

description: Single molecule trajectories of 1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbo -cyanine perchlorate (DiI) fluorophores diffusing on planar supported 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers imaged through total internal reflection fluorescence (TIRF) microscopy at different temperatures are investigated. The spatial resolution limit for detecting molecular motion is evaluated by characterizing the apparent motion which arises from the limited signal-to-noise ratio (S/N) of imaged and simulated stationary DiI molecules. Statistical criteria for reliably distinguishing molecular motion from stationary molecules using F-test statistics, including the computation of local signal-to-noise ratios are then established and used for reliably detecting subdiffraction motion of DiI molecules on DMPC.  The same single molecule tracking concept is used in investigating the temperature dependence of subdiffraction diffusional confinement of single Rhodamine 6G molecules in polymer brushes of poly (N-isopropylacrylamide), pNIPAAm, above and below its lower critical solution temperature (LCST) of 32 °C. Reliably distinguishing subdiffraction molecular motion from stationary events is crucial in validating the application of single molecule tracking experiment in probing nanometer-sized hydrophobic environments of polymer structure.  A versatile and rapid sol-gel technique for the fabrication of high quality one-dimensional photonic bandgap materials was developed. Silica/titania multilayer   materials are fabricated by a sol-gel chemistry route combined with dip-coating onto planar or curved substrate. A shock-cooling step immediately following the thin film heat-treatment process is introduced. The versatility of this sol-gel method is demonstrated by the fabrication of various Bragg stack-type materials with fine-tuned optical properties. Measured optical properties show good agreement with theoretical simulations confirming the high quality of these sol-gel fabricated optical materials.  Finally, magnetic functionalization studies of sol-gel derived Co-ion doped titania thin films using superconducting quantum interference device (SQUID) magnetometry and an attempt to measure their magneto-optical properties using a home-built Faraday rotation setup are discussed. The experimental limitations in reliably measuring magnetization responses of these thin films are introduced and discussed in detail.  The summary and outlook chapters summarize the scientific significance of each research project and briefly introduce ongoing research based on the work and the results presented in this dissertation.
Leishmanicidal and trypanocidal potential of the essential oil of Psidium myrsinites DC.
Creators: name: Vandesmet, Lilian Cortez Sombra
name: de Menezes, Saulo Almeida
name: Portela, Benedito Yago Machado
name: Sampaio, Mariana Gomes Vidal
name: dos Santos, Cícero Ramon Bezerra
name: Lermen, Vilmar Luiz
name: Gomez, Maria Celeste Vega
name: da Silva, Márcia Vanusa
name: de Alencar Menezes, Irwin Rose
name: dos Santos Correia, Maria Tereza
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Neglected tropical diseases (NTDs) are a group of pathologies caused by infectious agents or parasites, including the protozoa Leishmania sp. and Trypanosoma cruzi, which cause leishmaniasis and Chagas disease, respectively. The complications of the treatment regimen indicate the urgent need to search for new strategies and therapeutic agents. Among these is the essential oil of Psidium myrsinites DC. The essential oil of the leaves (PMEO) was evaluated in vitro, and cytotoxic activity was analysed against promastigotes of Leishmania braziliensis and Leishmania infantum and epimastigotes of Trypanosoma cruzi, as well as mammalian cells. The results showed that the PMEO had relevant activity against L. braziliensis, low cytotoxicity and a high selectivity index SI = 6.6. These results suggest that PMEO has antiparasitic potential against L. braziliensis, making this species is a possible alternative therapeutic source, given its effectiveness in the in vitro tests performed, opening the possibility of new biological studies in vivo.
Brief an [Johann III Bernoulli]
Creators: name: Schulze, Johann Karl
Publisher: name: [s.n.]
Year: 1777

description: von J[ohann] C[arl] [Gottlieb] S[chulze]
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 143: Daten der Mondfinsternis vom 10. Sept. 1783
description: Siehe auch: Basel UB, L Ia 686:S.711
Brief an [Johann Friedrich Henkel]
Creators: name: Schroeck, Lucas
Publisher: name: [s.n.]
Year: 1729

description: von L[ukas] Schröck
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Automated QRS detection in the presence of noise.
Creators: name: Adams, Isabelle M.
Publisher: name: University of Utah
Year: 2012
Subjects: Monitoring, Physiologic

description: Accurate QRS detection is essential in online computerized rhythm monitoring systems.  A major cause of error in QRS detection schemes arises from artifacts superimposed on the input signal.  To a lesser extent identification of P or T waves as QRS complexes can represent another source of error.  In an effort to reduce the incidence of false and missed alarms generated by the rhythm monitoring system currently used in the LDS Hospital Coronary Care Unit, a project was undertaken to improve the accuracy and reliability of the QRS detection algorithm, specifically in contaminated single lead electrocardiographic data.  The algorithm uses a dual scan of the sample data combined with a peak detection scheme to locate a reference point on a QRS candidate.  The candidate is then checked for evidence of baseline shift or an excessively low signal-to-noise ratio.  If neither of these criteria is met, the candidate is assumed to be QRS and a fiducial point is located on the complex.  To assess the sensitivity and specificity of the QRS detection algorithm, an off-line evaluation was performed on forty-one patient records collected in the Coronary Care Unit.  Arrhythmias included in the evaluation were fast ventricular and atrial rhythms and heart block.  Over 90 percent of the data base was contaminated with excessive muscle artifacts.  Of a total of 7,205 beats used in the evaluation, and positive predictive accuracy were .9641 and .9573, respectively.  Of the error, 92.16 percent of the false positives and 84.17 percent of the false negatives were due to excessive noise spike superimposition on the data.  None of the false positive error (.0071) was due to P or T wave misidentification of a QRS complex.  These results indicate that a signal-in-noise approach to automated QRS detection is effective in identifying QRS complexes in the contaminated single lead electrocardiogram with minimal error.
Byrsopolis chassaini Soula 2010
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Byrsopolis
Byrsopolis chassaini

description: Byrsopolis chassaini Soula, 2010
Byrsopolis chassaini Soula 2010b: 46 (French Guiana)
Distribution. French Guiana: Soula 2010b: 46; Carvalho and Grossi 2018: 372.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 127, DOI: 10.5281/zenodo.3678492
Effects of methamphetamine on striatal neuropeptide Y function.
Creators: name: Westwood, Scot C
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Striatal
subject: Dopamine: Psychosis
subject: Pharmacology
subject: Toxicology
subject: Neurology
subject: Physiological Psychology

description: Neuropeptide Y (NPY) has been shown to interact with dopamine (DA) systems and may play a role in DA-related psychotic disorders. Because of this association, we determined and compared the effects of psychomimetic drugs on NPY systems in the basal ganglia. We observed that phencyclidine, methamphetamine (METH), (+)methylenedioxymethamphetamine, and cocaine similarly reduced the striatal content of NPY-like immunoreactivity (NPYLI) from 54%â€"74%. METH decreased NPYLI in specific regions of striatum and nucleus accumbens at time points prior to one week after exposure, but at 1 week NPYLI had returned to control levels. There was no effect of METH on NPYLI in the substantia nigra or globus pallidus. The DA D-1 receptor antagonist SCH-23390, but not the DA D-2 receptor antagonist eticlopride, blocked the effects of METH on NPYLI. We also examined the effects of METH treatment on preproNPY mRNA levels in striatum There was no change in the amount of expression of preproNPY mRNA per cell, but there was a significant increase in the number of neurons expressing preproNPY mRNA 3â€"15 hr after exposure to METH. Values returned to normal by 1 week after exposure. The D-1 DA receptor antagonist SCH-23390, but not the D-2 DA receptor antagonist eticlopride, again blocked the effect. These results indicate that the METH-induced changes in NPY in the striatum are mediated by D-1 DA receptors. Because we saw decreased levels of striatal NPYLI, but increases in the number of cells expressing preproNPY, and no evidence for toxicity, we conclude that the most likely explanation for the decreased NPYLI, levels is increased release of NPY from the striatal interneurons. Because NPY has been shown to decrease the release of DA in the striatum the increased release is most likely an attempt of the NPY interneurons to reduce the release of DA from nigrostriatal neurons. Depletion of NPY stores, as reflected by decreased tissue levels of NPYLI, may lead to a nigrostriatal neurons. Depletion of NPY stores, as reflected by decreased tissue levels of NPYLI, may lead to a subsequent inability of NPY neurons to regulate subcortical DA release, leading to DA-induced psychosis.
COMPARATIVE STUDY OF THE PHYTOCHEMICAL AND ANTIBACTERIAL PROPERTIES OF TWO DIFFERENT VARIETIES OF Dioscorea bulbifera TUBERS
Creators: name: Ifeoma Enweani
Publisher: name: figshare
Year: 2020
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The phytochemical composition and the antibacterial potential of two different varieties (edible and wild types) of Dioscorea bulbifera tubers were determined using standard microbiological and physico-chemical methods. Extraction of bioactive compounds of the samples was done using aqueous, ethanol and methanol solvents.
Cytotoxicity, mutagenicity and acute oral toxicity of aqueous Ocotea minarum leaf extracts
Creators: name: da Silva Dantas, Fabiana Gomes
name: de Araújo, Renata Pires
name: de Almeida-Apolonio, Adriana Araújo
name: de Castilho, Pamella Fukuda
name: de Oliveira Galvão, Fernanda
name: Negri, Melyssa
name: Oesterreich, Silvia Aparecida
name: Cardoso, Claudia Andrea Lima
name: de Oliveira, Kelly Mari Pires
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Ocotea minarum (Nees & Mart.) Mez., a native species of Brazil, is used in the treatment of infections and oxidative stress; however, there is no scientific evidence of its toxicological characteristics. We assessed the cytotoxicity, mutagenic activity, and acute oral toxicity of the aqueous extract isolated from O. minarum leaves. The cytotoxicity of this extract was evaluated in tumour and non-tumour cell lines, while the Ames test with a Salmonella Typhimurium was used to determine the mutagenic activity. Wistar rats received a single 2 g/kg dose as part of an LD50 toxicity assessment. Our results showed that the aqueous extract of O. minarum leaves did not present cytotoxic and mutagenic properties and was not toxic, with an LD50 greater than 2 g/kg. Therefore, the O. minarum extracts are pharmacologically safe and can continue to be investigated for the development of new drugs and herbal medicines.
title: Essays in the spatial economic analysis of social interactions
Creators: name: Diemer, Andreas
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2020

description: This thesis examines the role of social interactions in economic geography from several different angles. It draws on and dialogues with literatures in related fields such as spatial and urban economics, regional science, economic sociology, and innovation economics, to explore how the geographical and social spaces are interlinked. The thesis comprises an introduction and three essays, all focused on the United States. The first essay considers the notion of social capital from a territorial perspective and investigates the role of manufacturing decline in its accumulation. It documents a positive relationship between the two, but also highlights significant challenges in the stability and interpretation of this result. The essay thus questions how well the notion of social capital lends itself to measurement and empirical analysis. The second essay uses a direct and broad measure of the social connectedness of regions to examine its role in transferring knowledge across the entire US geography. It uncovers a small yet significant and robust effect of social connection on knowledge flows as proxied by patent citations. The effect matters above and beyond the pre-existing geography of production and the professional networks of inventors. The third and final essay uses US social connectedness data to investigate how plausibly exogenous surges in the local demand for jobs in the oil and gas industry during the ‘fracking boom’ can affect the economy of spatially distant but socially proximate places. Findings support a role for social interaction in the diffusion of local economic shocks. This effect is likely explained by the relocation of transient workers within the industry, providing new aggregate evidence in support of the literature on job information networks. The overriding contribution of this thesis is to underscore with new empirical evidence the importance of social interactions in the spatial distribution of economic activity, not just locally but also over large scale geographies.
Brief an [Johann III Bernoulli]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1785

description: von [Johann] Christian Schneider
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann III Bernoulli]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1786

description: von J[ohann] Ch[ristian] Schneider
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Byrsopolis ferrandi Soula 2010
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Byrsopolis
Byrsopolis ferrandi

description: Byrsopolis ferrandi Soula, 2010
Byrsopolis ferrandi Soula 2010b: 45 (French Guiana)
Distribution. French Guiana: Soula 2010b: 45; Carvalho and Grossi 2018: 372.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 127, DOI: 10.5281/zenodo.3678492
Chemical studies of antibodies and other serum gamma globulins
Creators: name: McFadden, Mary Louise
Publisher: name: University of Utah
Year: 2012
Subjects: Immunoglobulins
Gamma globulins

description: 1.  Eight immune rabbit ?-globulins and three abnormal human myeloma ?-globulins have been characterized by electrophoretic and ultracentrifugal studies.  2. Eight specific pneumococcal polysaccharide-rabbit antibody precipitates as well as normal and hyperimmune rabbit- ?-globulins were prepared.  3. The 2, 4-dinitroflurobenzene technique described by Sanger was used to determine the free amino groups of several rabbit, human, bovine and equine serum globulin preparations.  All the rabbit ?-globulins possess one N-terminal alanine residue and 70 lysine residues.  DNP-aspartic acid isolated from every hydrolysate of DNP-rabbit ?-globulin suggests the presence of a labile bond involving the amino group of an aspartyl residue.  Human ?-globulin II-1, 2 has one N-terminal aspartic acid residue and two N-terminal glutamic acid residues; human ?-globulin II-3, one aspartic and one glutamic acid as N-terminal residues.  These findings suggest that human ?-globulin is a mixture of several different proteins, some composed of two or more polypeptide chains.  The two ?-globulins isolated from the sera of multiple myeloma patients each has two N-terminal glutamic acids.  The lysine content of these proteins, however, differs.  A purified cryoglobulin has approximately 1.5 moles each of N-terminal aspartic and glutamic acid residues indicating that it also is a mixture of at least two ?-globulins.  The hydrolysates of DNP-derivatives of bovine and equine serum globulins as well as a specifically precipitated equine antibody contained several DNP-amino acids each present in less that a molar quantity.  This suggest that bovine and equine serum globulin like human ?-globulin is a mixture of many proteins which differ in the nature of their N-terminal residues.  4. The N-terminal sequence of amino acid residues in four specific rabbit antibodies was determined by methods described by Sanger and Porter.  The sequence alanylleucylvalylaspartylglutamyl which occurs in rabbit antiovalbumin and normal rabbit ?-globulin occurs in each of these antibodies suggesting that only one species of ?-globulin is produced by the rabbit.  5. Amino acids are hydrolyzed from human and rabbit ?-globulins by carboxy-peptidase.  These proteins, therefore, apparently have one or more free ?-carboxyl groups.  6. The amino acid composition of four rabbit antibodies and two human myeloma ?-globulins has been determined mainly by chromatography of hydrolysates of the proteins of columns of Dowex 50.  No difference in the composition of the rabbit antibodies was found.  The abnormal human ?-globulins differ significantly from each other and from normal human ?-globulin,  7. The significance of these data has been discussed in terms of the current theories of antibody formation.
Structural dynamics govern substrate recruitment and catalytic turnover in H/ACA RNP pseudouridylation
Creators: name: Schmidt, Andreas
name: Hanspach, Gerd
name: Hengesbach, Martin
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology
subject: Computational Biology

description: H/ACA ribonucleoproteins catalyse the sequence-dependent pseudouridylation of ribosomal and spliceosomal RNAs. Here, we reconstitute site-specifically fluorophore labelled H/ACA complexes and analyse their structural dynamics using single-molecule FRET spectroscopy. Our results show that the guide RNA is distorted into a substrate-binding competent conformation by specific protein interactions. Analysis of the reaction pathway using atomic mutagenesis establishes a new model how individual protein domains contribute to catalysis. Taken together, these results identify and characterize individual roles for all accessory proteins on the assembly and function of H/ACA RNPs.
Brief an [Johann III Bernoulli]
Creators: name: Schulze, Johann Karl
Publisher: name: [s.n.]
Year: 1776

description: von J[ohann] C[arl] [Gottlieb] Schulze
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 141: Beobachtungen eines Kometen, 25.1.-15.4.1779
Porsenna Mausoleum
Creators: name: FELDMANN, PETER
Publisher: name: Zenodo
Year: 2024
Subjects: porsenna, mausoleum, necropolis, grabmal, tomb, architecture, tumulus, quincunx, phallisch, phallic, chiusi, clusium, computer-archäologie, computer archaeology, new image technology, rekonstruktion, reconstruction, virtual reality, etrusker, etruscans, etruscology, iron-age, albano laziale, fergusson, nintoku, varro, blender

description: New virtual reconstruction made with 3d-freeware blender. Seven slides explain the enigmatic text of Varro describing the tomb of an iron-age war chief in Etruria.
Investigation of the EU27 Member State’s cultural and social habits gender-disaggregated and how these may impact national decarbonising.
Creators: name: Perissi, Ilaria
name: Jones, Aled
Publisher: name: Anglia Ruskin University
Year: 2022
Subjects: Human impacts of climate change and human adaptation

description: Task 1.3 aims to assess the EU27 Member State’s cultural and social habits gender-disaggregated where possibly, and how these may impact national decarbonizing. The study is split into two main steps • Based on Eurostat statistics, evaluation of the energy intensity of the EU 27 household’ activities grouped by “Classification of Individual Consumption According to Purpose (COICOP)”, to highlight which, among these activities, are more energy consuming (no gender disaggregation possible) • Investigations on European citizens' habits based on Eurobarometer surveys to explore policy implementation based on citizens' attitudes (gender-disaggregated).
Quantum mechanics and experimental solid-state nuclear magnetic resonance analysis of strained molecular systems
Creators: name: Halling, Merrill David
Publisher: name: University of Utah
Year: 2012
Subjects: Strained molecular systems
Chemical shift tensors
Density functional theory
DFT
NMR
Nuclear magnetic resonance
Solid-state NMR

description: In this work 13C solid-state NMR and quantum mechanical studies of strained molecular systems are discussed. The chemical shift tensor values reported in this document were obtained using the FIREMAT method. Theoretical analyses of chemical shielding tensors were performed through the computer nodes operated by the Utah Center for High Performance Computing. Analyses were performed on sumanene, indenofluoranthene, tetrathiafulvalene, tetrathiafulvalene dimer, [2,2]paracyclophane, and 1,8-dioxa[8](2,7)pyrenophane.  The FIREMAT data were fit using the TIGER data processing technique. TIGER provides a means to fit the FIREMAT data, accommodating its unique phase and relaxation characteristics. The details of the FIREMAT experiment are discussed in Chapter 1. The experimentally obtained chemical shift data were compared with calculated chemical shielding data. For these molecular systems, density functional theory was used along with the B3LYP exchange and correlation functionals. Multiple basis sets were used and relatively low errors are reported, between 2.0 ppm and 4.2 ppm. The errors reflect the difference between experimental and theoretical results. The relatively small errors are consistent with those of other polycyclic aromatic hydrocarbons (PAHs) and similar molecular systems. Chapter 2 discusses the three-dimensional aspect of tensor error analysis and how it is used in determining the errors associated with comparing two chemical shift tensors, i.e., theoretically derived and experimentally determined tensors. All error values reported and discussed in this dissertation are determined using this error analysis method.  Molecular conformation may be explored by variation in chemical shift tensor principal values. The ring strain in curved polycyclic aromatic hydrocarbons can be associated with downfield shifts in the ?33 component of the chemical shift tensor. This is discussed in Chapters 3 and 5, as it relates to sumanene, indenofluoranthene, [2,2]paracyclophane, 1,8-dioxa[8](2,7)pyrenophane and how they compare to C60. Theoretical energy and NMR calculations, when compared with experimental solid-state NMR data, may also be used to refine X-ray crystal structures. This is useful in predicting the location of Hydrogen atoms in X-ray structures. Long bonding interactions are discussed in Chapter 4 regarding TTF and [TTF]22+ dimers.
Leishmanicidal and trypanocidal potential of the essential oil of Psidium myrsinites DC.
Creators: name: Vandesmet, Lilian Cortez Sombra
name: de Menezes, Saulo Almeida
name: Portela, Benedito Yago Machado
name: Sampaio, Mariana Gomes Vidal
name: Santos, Cícero Ramon Bezerra dos
name: Lermen, Vilmar Luiz
name: Gomez, Maria Celeste Vega
name: da Silva, Márcia Vanusa
name: de Alencar Menezes, Irwin Rose
name: Correia, Maria Tereza dos Santos
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Neglected tropical diseases (NTDs) are a group of pathologies caused by infectious agents or parasites, including the protozoa Leishmania sp. and Trypanosoma cruzi, which cause leishmaniasis and Chagas disease, respectively. The complications of the treatment regimen indicate the urgent need to search for new strategies and therapeutic agents. Among these is the essential oil of Psidium myrsinites DC. The essential oil of the leaves (PMEO) was evaluated in vitro, and cytotoxic activity was analysed against promastigotes of Leishmania braziliensis and Leishmania infantum and epimastigotes of Trypanosoma cruzi, as well as mammalian cells. The results showed that the PMEO had relevant activity against L. braziliensis, low cytotoxicity and a high selectivity index SI = 6.6. These results suggest that PMEO has antiparasitic potential against L. braziliensis, making this species is a possible alternative therapeutic source, given its effectiveness in the in vitro tests performed, opening the possibility of new biological studies in vivo.
Development of a structured selection interview for staff pharmacists
Creators: name: Reitz, Bruce Alan
Publisher: name: University of Utah
Year: 2012
Subjects: Employment interviewing
Pharmacists

description: This study outlined procedures for the development of a structured selection interview that could be used in the hiring of pharmacists.  Steps in the development of the interview included establishment of minimum job requirements and performance of a job analysis of the pharmacist position.   The  preceding were done to determine job duties and their relative importance.  Job-related questions to be used in the selection interview were composed and weight from the data collected in the job analysis.  A system for scoring the interview was developed as well as a set of records for documentation of the interview results.  In addition, a training program was outlined that would instruct interviewers of the selection interview procedure, the position for which they are interviewing, and the essentials of objective data collection techniques.  Of importance, the project produced a  practical ser of procedures that could be followed by pharmacy director in the development of a selection interview, tailored to their particular  department.
Brief an [Johann III Bernoulli]
Creators: name: Schneider, Johann Gottlob
Publisher: name: [s.n.]
Year: 1791

description: von [Johann Gottlob] Schneider
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Cytotoxicity, mutagenicity and acute oral toxicity of aqueous Ocotea minarum leaf extracts
Creators: name: da Silva Dantas, Fabiana Gomes
name: de Pires Araújo, Renata
name: de Almeida-Apolonio, Adriana Araújo
name: de Castilho, Pamella Fukuda
name: de Oliveira Galvão, Fernanda
name: Negri, Melyssa
name: Oesterreich, Silvia Aparecida
name: Cardoso, Claudia Andrea Lima
name: de Oliveira, Kelly Mari Pires
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Ocotea minarum (Nees & Mart.) Mez., a native species of Brazil, is used in the treatment of infections and oxidative stress; however, there is no scientific evidence of its toxicological characteristics. We assessed the cytotoxicity, mutagenic activity, and acute oral toxicity of the aqueous extract isolated from O. minarum leaves. The cytotoxicity of this extract was evaluated in tumour and non-tumour cell lines, while the Ames test with a Salmonella Typhimurium was used to determine the mutagenic activity. Wistar rats received a single 2 g/kg dose as part of an LD50 toxicity assessment. Our results showed that the aqueous extract of O. minarum leaves did not present cytotoxic and mutagenic properties and was not toxic, with an LD50 greater than 2 g/kg. Therefore, the O. minarum extracts are pharmacologically safe and can continue to be investigated for the development of new drugs and herbal medicines.
Brief an [Christfried Kirch]
Creators: name: Schübler, Johann Jacob
Publisher: name: [s.n.]
Year: 1734

description: von J[ohann] J[acob] Schübler
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 72: Specification meiner bereits zum Vorschein gekommenen Bücher
Brief an [Johann III Bernoulli]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1788

description: von J[ohann] Ch[ristian] Schneider
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Factors related to use of internet parent support groups by primary caregivers of a child with special health care needs
Creators: name: Baum, Lynda S.
Publisher: name: University of Utah
Year: 2012
Subjects: Chronically ill children
Family relationships
Parent-Child Relations
Internet

description: The purpose of this study was to explore and describe factors related to use of Internet parent support groups (IPSG) by primary caregivers of a child with special health care needs (CSHCN) at home. The Transactional Model of Stress, Coping and Adaptation was used as a framework for developing an Internet survey which was completed by a sample of 114 primary caregivers, caring for 140 CSHCN, using over 100 different Internet parent support groups. Power analysis for correlations with a moderate effect size required a minimum sample size of 85 (alpha = >.05, beta = .80). Retrospective self-report was in the form of both narrative and Likert type ratings. Outcome variables included perceived satisfaction, social support, change of view, positive and negative emotion, somatic health, physical functioning, family relationships, and wellbeing. The typical participant was a White, well-educated American mother in her late 30s caring for a 3-year-old male with a chronic disability. Participants used a variety of coping strategies, but unusually high optimism scores may have skewed perceptions. The top two motives for seeking online social support were "to get usable ideas" (99%) and "to help others" (94%). The majority not only obtained what they sought, but found more than expected in terms of insight and people to trust. The highest ranking sources of emotional support were family (52%), with IPSGs as a strong second. Strongest relationships (p > .001) with satisfaction were finding people to trust (r > = .44) and improved caregiver-CSHCN relationship (r = .42). Finding people to trust was more powerfully related to positive feelings than any other type of support. The top three things having the most long-lasting effect on wellbeing were finding people with similar circumstances (79%), receiving guidance and information (59%), and understanding and acceptance. The majority agreed their viewpoint changed with IPSG use (64%). IPSGs primarily generated positive feelings, especially hope (87%). They were associated with improved physical functioning (73%), mostly did not interfere with sleep (61%), or result in neglect of the family (68%). Caregivers recommended participating in an IPSG as soon as possible, and many recommended belonging to more than one. It appears that IPSGs may be an important adjunct for social support for primary caregivers of a CSHCN, but further research is needed to establish their efficacy and function.
Antiproliferative activity of semisynthetic xylopic acid derivatives
Creators: name: Soh, Désiré
name: Ernestine, Nkwengoua
name: Satchet, Emmanuella Marthe Tchana
name: Defokou, Ulrich Dzo
name: Schneider, Bernd
name: Giovanni, Vidari
name: Nyassé, Barthélemy
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Two ent-kaurene diterpenoids, ent-15-β-acetyloxy-kaur-16-en-19-oic acid (xylopic acid) 1 and ent-7-oxo-kaur-16-en-19-oic acid 2 were isolated from the fruits of Xylopia aethiopica. Chemical manipulation of xylopic acid yielded ent-kaurane derivatives 3, 4, 5, and 6. Their structures were elucidated by spectroscopic analysis, including 1 D- and 2 D-NMR spectroscopies. The antiproliferative activities of compounds 1, 2, 3, 4, and 6 were tested on breast MCF7 and SkBr3, endometrial Ishikawa, ovarian BG-1, mesothelioma IST-MES1 and hepatocellular HepG2 human tumor cells, and on mammalian MRC-10 fibroblast cells. Ketone 2 showed significant antiproliferative activity against MFC7 human breast cancer cells (IC50 = 3 ± 1 µM) and A549 pulmonary adenocarcinoma (8 ± 1 µM), that was higher than the well-known anti-cancer agent cisplatin (IC50 = 19 ± 3 and 15 ± 4 µM, respectively).
Numero zero
Creators: name: Metro, Antonino
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Giuridiche, Economiche e Politiche
Year: 2018

description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Giuridiche, Economiche e Politiche, Vol 87, No 1 (2018)
APPUNTI PER UNA RICOSTRUZIONE SISTEMATICA NELL’OTTICA DEL DIRITTO PUBBLICO DEGLI EFFETTI CHE DERIVANO DAGLI STATI D’URGENZA E DALL’EMERGENZA SULLA PROTEZIONE DELLE SITUAZIONI GIURIDICHE SOGGETTIVE (AVUTO PARTICOLARE RIGUARDO AI FENOMENI MIGRATORI ED ALLA COSIDDETTA AMMINISTRAZIONE DELL’EMERGENZA)
Creators: name: Astone, Francesco
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Giuridiche, Economiche e Politiche
Year: 2018

description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Giuridiche, Economiche e Politiche, Vol 87, No 1 (2018)
Zinc finger nuclease-induced double-strand breaks mediate targeted mutagenesis in Caenorhabditis elegans
Creators: name: Morton, John Jason
Publisher: name: University of Utah
Year: 2012
Subjects: Chimeric Proteins
Gene Targeting

description: Zinc finger nucleases (ZFNs) are chimeric proteins composed of a DNA-binding domain comprised of several tandem Cys2His2 zinc fingers and a nonspecific endonuclease domain from the Type IIs restriction enzyme FokI.  When expressed in the nematode Caenorhabditis elagans, these molecules bind it's DNA at a sequence specified by the zinc fingers and produces double-strand breaks (DSBs) at this target site in somatic tissues.  These breaks activate the nematode DNA repair mechanisms, which attempt to repair the lesions either by homologous recombination (HR), using an unbroken homologous DNA template, or by nonhomologous end joining (NHEF), by which the broken ends are simply rejoined without regard for sequence conservation.  The latter process will, at some frequency, produce targeted mutations at the break site.  The work present characterizes ZFN-mediated mutagenesis in the somatic tissue of the nematode.  Expression of sets of ZFNs, designed to specifically cleave either a synthetic site on an extrachromosomal array or a genomic target, resulted in a spectrum of NHEJ-medicated target site mutations at a frequency of about 20% of each locus.  Elimination of the canonical NHEJ pathway in the nematode significantly altered the frequency and types of mutations observed, indicating that this process is fundamental in repairing ZFN-induced DSBs.  It is hoped that the information gained from these studies will serve as a guide in the use of ZFNs for germline mutagenesis and gene targeting in the nematode.   Use of this technology together with an introduced altered DNA template to direct HR-mediated DSB repair will herald the arrival of a long-sought method of efficient gene targeting of C. elagans.
Intercrystalline solution ion activity product basis of subsurface dissolution in a hydroxyapatite system.
Creators: name: Bergstrom, David Henry
Publisher: name: University of Utah
Year: 2012
Subjects: Dental enamel
Dental caries
Hydroxyapatite
Fluorides

description: Recognition of the importance of low level solution fluoride on the propensity of bovine enamel to form an intact surface layer with concomitant subsurface dissolution in an in vitro bovine enamel model hydroxyapatite system has led to the development of a comprehensive physical and mathematical model capable of predicting experimental observations over a wide range of solution chemistries and hydrodynamics. It has been found that as bulk solution fluoride diffuses into the enamel matrix it is adsorbed by the hydroxyapatite crystallites in the surface region. Upon saturation of the available adsorption sites in this surface region the intercrystalline solution ion activity product (K(,FAP) = a(,Ca)('10)(.)a(,PO(,4))('6)(.)a(,OH)('2)) is elevated above a critical value (pK(,FAP) = 115.0 (+OR-) 1.0) and further dissolution of this surface region is inhibited. At the same time because of the adsorption/depletion mechanism, dissolution may proceed at a finite rate beyond the advancing fluoride front resulting in subsurface dissolution with simultaneous preservation of the crystallites in the surface region. Consideration of the appropriate diffusion, reaction and chemical equilibria equations has enabled theoretical computer simulation of the subsurface dissolution phenomenon. Calculations have shown that the theoretical model is semi-quantitatively descriptive of the mineral density changes occurring within the hydroxyapatite matrix as a function of time and position.
Anticheira Eschscholtz 1818
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Anticheira

description: ANTICHEIRA Eschscholtz, 1818
Anticheira Eschscholtz 1818: 475
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 127, DOI: 10.5281/zenodo.3678492
LUNGA VITA AI PRODOTTI INDUSTRIALI !
Creators: name: Basile, Massimo
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Giuridiche, Economiche e Politiche
Year: 2018

description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Giuridiche, Economiche e Politiche, Vol 87, No 1 (2018)
Augmented phytotoxic effect of nanoencapsulated ophiobolin A
Creators: name: Vurro, Maurizio
name: Townley, Helen E.
name: Morrison, Rachel
name: Boari, Angela
name: Masi, Marco
name: Evidente, Antonio
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology

description: Ophiobolin A is a secondary phytotoxic metabolite produced by some pathogenic fungal species responsible for severe plant diseases, considered to play a role in disease development and symptom appearance. Herein we investigated whether the phytotoxic activities of ophiobolin A against weed species could be improved by nanoencapsulation. Given the rapid natural degradation of the compound, it was hoped that nanoencapsulation would prolong the phytotoxic effects or enhance the bioactivity, thus leading to improved weed control capabilities. This article presents an assessment of the effectiveness of encapsulated ophiobolin A on 11 commonly found weed species, compared to the pure ophiobolin, to the particle alone, and a combination of mixed particles and ophiobolin A, by applying the solution droplets to both intact or injured leaf surface, on the adaxial or abaxial side. The bioassays showed the improved efficacy of the encapsulated ophiobolin, and the need for leaf lesions to diffuse the particles into the tissues.
Nurse-midwife support at home and success with breast feeding
Creators: name: Ament, Constance Joyce Abell
Publisher: name: University of Utah
Year: 2012
Subjects: Maternity Nursing
Midwifery

description: The purpose of this study was to investigate the influence of professional support on success with breast feeding.  The hypothesis was as follows:  the group with teaching and support by nurse-midwife during the postpartum period will demonstrate a greater degree of success with breast feeding than the group without such teaching and support.  Success was measured by the total number of days breast fed during which supplementation was given less than once in 24 hours and normal infant weight gain was achieved.  Subjects were selected among patients delivered by private obstetricians at a private 570-bed general hospital.  A sample of 24 married primiparas women were used to establish the experimental and control groups.  The experimental group did not breast feed a significantly greater number of days (F ratio = .537, p = .467), However, they did have a greater number of mothers breast feedings at 6 weeks postpartum; 75% of the experimental group were breast feeding at 6 weeks postpartum, in contrast to 58.3% if the control group.  This difference was not statistically significant (F ratio = .710, p = .409), because the difference between the groups was not greater than the difference within the groups.  The experimental group tended to feed less cereal than the control group (F ratio = 2.59, p =  .122); however, no difference was noted in the formula supplementation used by the two groups (F ration = .281, p = .601).  The data from the initial hospital interview form, designed primarily to identify possible intervening variables, indicated five areas of difference between the experimental and the control groups.  The investigator believed the effect of support on the experimental group was suppressed because of this initial difference between the two groups.  A total of 451 needs were identified during 48 contacts with mothers in the experimental group.  The mothers identified 71% of the needs, and the investigator identified the remaining 29%.  The average number of needs of problems identified for each contact was 7.4.  The investigator classified each need as unresolved, partially resolved, or resolved.  Twenty-six percent of the needs identified were classified as unresolved, 48% as partially resolved, and 25.5% as resolved.  Thus 73.5% of the needs either were resolved or showed movement towards resolution.  One of the most interesting findings of this study was that the mother tended either to be settled into breast feedings or to have reacted a decision to wean the baby to a bottle by the eleventh to the eighteenth day postpartum.
Brief an [Johann III Bernoulli]
Creators: name: Schneider, Johann Gottlob
Publisher: name: [s.n.]
Year: 1788

description: von J[ohann] G[ottlob] Schneider
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Development, characterisation, stability study and antileukemic evaluation of nanoemulsions containing Astrocaryum aculeatum extract
Creators: name: Copetti, Priscila Marquezan
name: da Silva Gündel, Samanta
name: de Oliveira, Pablo Sebastian Britto
name: Favarin, Fernanda Reis
name: Ramos, Andiara Prates
name: Pintos, Francieli Guedes
name: Pappis, Lauren
name: Gündel, André
name: Machado, Alencar Kolinski
name: Ourique, Aline Ferreira
name: Sagrillo, Michele Rorato
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characteristics (average size approx. 200 nm, polydispersity index less than 0.3, negative zeta potential and acid pH) maintained stable up to 90 days of storage in refrigeration condition. The nanoformulations did not present protein corona formation. Blank nanoemulsion treatments showed moderate toxicity. Furthermore, the nanoemulsion loaded with extract showed better antileukemic results than the free extract. However, nanoemulsions can be promising carriers of natural compounds, emphasising their biological properties and constituting alternatives in treating diseases.