cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation
Creators: name: Huiwen Song
name: Pu, Jun
name: Wang, Lin
name: Lihua Wu
name: Jianmin Xiao
name: Qigong Liu
name: Chen, Jun
name: Zhang, Min
name: Liu, Yang
name: Mingke Ni
name: Jinggang Mo
name: Yunliang Zheng
name: Deli Wan
name: XiongJiu Cai
name: Yaping Cao
name: Weiyi Xiao
name: Ye, Lei
name: Enyuan Tu
name: Zhihai Lin
name: Jianxin Wen
name: Xiaoling Lu
name: He, Jian
name: Peng, Yi
name: Su, Jing
name: Zhang, Heng
name: Yongxiang Zhao
name: Meihua Lin
name: Zhiyong Zhang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecting the formation of autophagosomes, the post-translational modification of ATG16L1 remains elusive. Here, we explored the regulatory mechanism and role of ATG16L1 phosphorylation for autophagy induction in cardiomyocytes. We showed that ATG16L1 was a phosphoprotein, because phosphorylation of ATG16L1 was detected in rat cardiomyocytes during hypoxia/reoxygenation (H/R). We not only demonstrated that CSNK2 (casein kinase 2) phosphorylated ATG16L1, but also identified the highly conserved Ser139 as the critical phosphorylation residue for CSNK2. We further established that ATG16L1 associated with the ATG12-ATG5 complex in a Ser139 phosphorylation-dependent manner. In agreement with this finding, CSNK2 inhibitor disrupted the ATG12-ATG5-ATG16L1 complex. Importantly, phosphorylation of ATG16L1 on Ser139 was responsible for H/R-induced autophagy in cardiomyocytes, which protects cardiomyocytes from apoptosis. Conversely, we determined that wild-type PPP1 (protein phosphatase 1), but not the inactive mutant, associated with ATG16L1 and antagonized CSNK2-mediated phosphorylation of ATG16L1. Interestingly, one RVxF consensus site for PPP1 binding in the C-terminal tail of ATG16L1 was identified; mutation of this site disrupted its association with ATG16L1. Notably, CSNK2 also associated with PPP1, but ATG16L1 depletion impaired the interaction between CSNK2 and PPP1. Collectively, these data identify ATG16L1 as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12-ATG5-ATG16L1 complex and autophagy induction.
Ambiente di apprendimento nelle scuole di specializzazione mediche in Italia: una survey pilota
Creators: name: Olivero, Alberto
name: Cuniberti, Francesco
name: Stefan, Andreea Beatrice
name: Trioni, Jacopo
name: Leombruni, Paolo
Publisher: name: Tutor
Year: 2024

description: Ambiente di apprendimento nelle scuole di specializzazione mediche in Italia: una survey pilota
description: Tutor, V. 23 N. 2
Using the information: Incorporating positive feedback information into the testing process
Creators: name: Chan, Kwok Ping
name: Towey, D.
name: Chen, Tsong
name: Kuo, Fei-Ching
name: Merkel, R.
Publisher: name: Swinburne
Year: 2024

description: Software testing is recognized as an essential part of the software development process. Random testing (RT), the selection of input test cases at random from the input domain, is a simple and efficient method of software testing. RT does not however make use of previously executed test case information; in particular, information about nonfailure-causing test cases is ignored. Intuitively, use of this positive feedback information can improve the failure-finding efficiency of a testing method. Adaptive random testing (ART) makes use of knowledge of general failure pattern types, and information of previously executed test cases, in the selection of new test cases. A failure pattern in a program's input domain is composed of the regions of failure-causing inputs. Previous research has categorized failure patterns broadly into three types: point; strip; and block, and has identified important implications for the failure-finding efficiency of test methods, depending on the failure pattern type. In particular, it has been found that for nonpoint type patterns, the efficiency of RT can be improved upon by simple modification of the basic approach: by ensuring a more even and widespread distribution of test cases over the input domain, the number of test cases required to find the first failure (F-measure) can be reduced dramatically. This insight has motivated several adaptive random testing methods, and produced convincing results. This paper introduces some of the research in this area and suggests areas of interest for future work.
Reproduction of the Western Marsh Harrier Circus aeruginosus at the El Maleh Dam reservoir in north-western Morocco
Creators: name: Rihane, Abdeslam
name: Nahli, Abdelmottalib
name: Hamoumi, Rhimou El
name: Chlaida, Mohamed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The reproduction of the Western Marsh Harrier Circus aeruginosus in submerged and dried up thickets of French tamarisk Tamarix gallica at El Maleh Dam reservoir, Benslimane Province, Morocco, was studied through monitoring nests in three successive years (2017–2019). Systematic field investigation showed that the nests were concentrated exclusively in a narrow and shallow area upstream of the dam. The abundance of tamarisk is a determining factor in the breeding success of the Western Marsh Harrier at this site, by supporting the nests and giving them some protection from predation while the birds are close to agricultural fields, a favourable hunting ground. A study of individual broods revealed a relatively small clutch size (3.5 eggs per nest) and that incubation took 32 days on average. Compared with previous reports for this species elsewhere, the chicks fledged relatively early (33 or 35 days), but with a low fledgling success rate not exceeding 33.9%. The low fledgling success is partly attributable to the structure of the habitat, as the dense dry vegetation above the water level limits the movement of chicks out of nests yet favours the drowning of those that fall from the nest. Breeding success is influenced by a reduction in hunting territory caused by drops in the water level during periods of drought, poor climate conditions, and disturbance caused by human activities in the reservoir lake and riparian farmland. In addition to these environmental factors, nest failure due to nest destruction is related to the experience of the pairs in choosing the nesting site and their ability to weave the nest-building materials. Further study is needed on the characteristics of this highly specific habitat and its state of conservation, the reproduction of coexisting bird populations, and human activities around the breeding site.
Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae
Creators: name: Siriporn Lunprom
name: Pongsanat Pongcharoen
name: Sekito, Takayuki
name: Kawano-Kawada, Miyuki
name: Kakinuma, Yoshimi
name: Akiyama, Koichi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Fusarium oxysporum causes wilt disease in many plant families, and many genes are involved in its development or growth in host plants. A recent study revealed that vacuolar amino acid transporters play an important role in spore formation in Schizosaccharomyces pombe and Saccharomyces cerevisiae. To investigate the role of vacuolar amino acid transporters of this phytopathogenic fungus, the FOXG_11334 (FoAVT3) gene from F. oxysporum was isolated and its function was characterized. Transcription of FoAVT3 was upregulated after rapamycin treatment. A green fluorescent protein fusion of FoAvt3p was localized to vacuolar membranes in both S. cerevisiae and F. oxysporum. Analysis of the amino acid content of the vacuolar fraction and amino acid transport activities using vacuolar membrane vesicles from S. cerevisiae cells heterologously expressing FoAVT3 revealed that FoAvt3p functions as a vacuolar amino acid transporter, exporting neutral amino acids. We conclude that the FoAVT3 gene encodes a vacuolar neutral amino acid transporter. Localization of vacuolar neutral amino acid transporter, GFP-FoAvt3p, in Fusarium oxysporum. FoAvt3p (green) functions as transporter of neutral amino acids from vacuole (blue) to cytosol.
Update on adoption of Wheat Data – Interoperability WG Outputs
Creators: name: Yeumo, Esther Dzalé
Publisher: name: F1000 Research Limited
Year: 2020

description: One prerequisite for the success of community‐based WG is to have at least a sponsor and ideally a sponsor that has legitimacy with regards the community. WDI was supported by the Wheat Initiative (https://www.wheatinitiative.org) and several well recognized and key players of domain of the wheat research.
title: Актуальные проблемы защиты имущественных интересов детей при совершении сделок их родителями
Creators: name: Сочнева, Ольга
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Уровень обеспечения потребностей ребенка в значительной мере зависит от благосостояния его родителей.
Соответственно, распоряжение родителями своим имуществом неизбежно затрагивает и материальное благополучие ребенка. Кроме того, родители могут совершать сделки, непосредственно направленные на обеспечение интересов ребенка (например, соглашения об алиментах, сделки по распоряжению принадлежащим ему имуществом), которые имеют немало особенностей. Вместе с тем правоприменительная практика свидетельствует о том, что действующие нормы, регулирующие указанные виды сделок, не в
полной мере отвечают интересам несовершеннолетних детей, а в ряде случаев приводят к возникновению конфликта интересов последних и третьих лиц. В статье проанализированы положения гражданского и
семейного законодательства, регламентирующие заключение и оспаривание сделок родителей с имуществом детей, алиментных соглашений, а также сделок по отчуждению детям принадлежащего родителям имущества.
Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae
Creators: name: Siriporn Lunprom
name: Pongsanat Pongcharoen
name: Sekito, Takayuki
name: Kawano-Kawada, Miyuki
name: Kakinuma, Yoshimi
name: Akiyama, Koichi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Biochemistry

description: Fusarium oxysporum causes wilt disease in many plant families, and many genes are involved in its development or growth in host plants. A recent study revealed that vacuolar amino acid transporters play an important role in spore formation in Schizosaccharomyces pombe and Saccharomyces cerevisiae. To investigate the role of vacuolar amino acid transporters of this phytopathogenic fungus, the FOXG_11334 (FoAVT3) gene from F. oxysporum was isolated and its function was characterized. Transcription of FoAVT3 was upregulated after rapamycin treatment. A green fluorescent protein fusion of FoAvt3p was localized to vacuolar membranes in both S. cerevisiae and F. oxysporum. Analysis of the amino acid content of the vacuolar fraction and amino acid transport activities using vacuolar membrane vesicles from S. cerevisiae cells heterologously expressing FoAVT3 revealed that FoAvt3p functions as a vacuolar amino acid transporter, exporting neutral amino acids. We conclude that the FoAVT3 gene encodes a vacuolar neutral amino acid transporter.
ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation
Creators: name: Huiwen Song
name: Pu, Jun
name: Wang, Lin
name: Lihua Wu
name: Jianmin Xiao
name: Qigong Liu
name: Chen, Jun
name: Zhang, Min
name: Liu, Yang
name: Mingke Ni
name: Jinggang Mo
name: Yunliang Zheng
name: Deli Wan
name: XiongJiu Cai
name: Yaping Cao
name: Weiyi Xiao
name: Ye, Lei
name: Enyuan Tu
name: Zhihai Lin
name: Jianxin Wen
name: Xiaoling Lu
name: He, Jian
name: Peng, Yi
name: Su, Jing
name: Zhang, Heng
name: Yongxiang Zhao
name: Meihua Lin
name: Zhiyong Zhang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecting the formation of autophagosomes, the post-translational modification of ATG16L1 remains elusive. Here, we explored the regulatory mechanism and role of ATG16L1 phosphorylation for autophagy induction in cardiomyocytes. We showed that ATG16L1 was a phosphoprotein, because phosphorylation of ATG16L1 was detected in rat cardiomyocytes during hypoxia/reoxygenation (H/R). We not only demonstrated that CSNK2 (casein kinase 2) phosphorylated ATG16L1, but also identified the highly conserved Ser139 as the critical phosphorylation residue for CSNK2. We further established that ATG16L1 associated with the ATG12-ATG5 complex in a Ser139 phosphorylation-dependent manner. In agreement with this finding, CSNK2 inhibitor disrupted the ATG12-ATG5-ATG16L1 complex. Importantly, phosphorylation of ATG16L1 on Ser139 was responsible for H/R-induced autophagy in cardiomyocytes, which protects cardiomyocytes from apoptosis. Conversely, we determined that wild-type PPP1 (protein phosphatase 1), but not the inactive mutant, associated with ATG16L1 and antagonized CSNK2-mediated phosphorylation of ATG16L1. Interestingly, one RVxF consensus site for PPP1 binding in the C-terminal tail of ATG16L1 was identified; mutation of this site disrupted its association with ATG16L1. Notably, CSNK2 also associated with PPP1, but ATG16L1 depletion impaired the interaction between CSNK2 and PPP1. Collectively, these data identify ATG16L1 as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12-ATG5-ATG16L1 complex and autophagy induction.
Conservation status and threats to lovebirds: knowledge gaps and research priorities
Creators: name: Dueker, Sascha
name: Willows-Munro, Sandi
name: Perrin, Michael R
name: Abebe, Yilma D
name: Annorbah, Nathaniel ND
name: Mwangi, Esther W
name: Madindou, Ireene R
name: Tekalign, Wondimagegnehu
name: Mori, Emiliano
name: Mzumara, Tiwonge I
name: Brown, Chris
name: Bryson, Ursula
name: Ndithia, Henry
name: Dodman, Tim
name: van der Zwan, Henriette
name: van der Sluis, Rencia
name: Phiri, Chaona R
name: Karimanzira, Abigail
name: Martin, Rowan O
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Lovebirds (genus Agapornis of family Psittaculidae) are a group of small, colourful parrot species endemic to sub-Saharan Africa and Madagascar, two-thirds of which are considered to have declining populations. Effective conservation efforts are hampered by a lack of information, particularly for species occurring in regions that have received little research attention. We combined expert knowledge with a review of the primary and grey literature to identify key knowledge gaps and priority conservation actions for this group of birds. Published studies were found to be largely concentrated on lovebird populations in southern Africa and, to a lesser extent in East Africa, and therefore mostly concern members of the ‘white eye-ring’ clade. Some species, such as the Black-collared Lovebird Agapornis swindernianus, remain very poorly studied, with a lack of even basic information such as georeferenced occurrence records. Several lovebird species were historically taken from the wild in large numbers for the international pet trade, leading to population declines. Although trade in wild lovebirds has been much reduced compared with historical levels, considerable numbers are still captured for local and international trade without any monitoring of the wild populations. Habitat change continues to drive declines in the population and range of some species, particularly those considered habitat specialists, such as the Nyasa Lovebird A. lilianae and the Black-cheeked Lovebird A. nigrigenis. However, changing habitat has also driven range expansions and, in combination with trade, has created numerous novel contact zones between formerly allopatric species, such as between Fischer’s Lovebird A. fischeri and Yellow-collared Lovebird A. personatus. Hybridisation has been widely reported, particularly in East Africa, and studies on the implications of this for conservation, building on recent advances in genetic tools, are urgently needed. We call for more targeted research on lovebirds to inform assessments of their population trends, to understand the drivers of these trends, and to highlight opportunities to leverage existing data and new research tools to advance knowledge to support conservation in this group of birds.
The four major challenges of engineering adaptive software architectures
Creators: name: Han, Jun
name: Colman, Alan
Publisher: name: Swinburne
Year: 2024

description: Building an adaptive software system that can cope with changing requirements and changing environments presents four major challenges. These are (1) to receive, represent and reason about changing requirements and goals; (2) to cope with volatility of the computational context in which it executes; (3) to work with other systems that are heterogeneous and distributed; and (4) to do all of the above without becoming too complex to develop and maintain. These challenges can be addressed by architectures that focus on the adaptivity of relationships rather than entities. Role-Oriented Adaptive Design (ROAD) is presented as such an architecture that addresses the challenges.
Consistency and interoperability checking for component interaction rules
Creators: name: Jin, Yan
name: Han, Jun
Publisher: name: Swinburne
Year: 2024

description: In component-based software development, it is important to ensure interoperability between components based on their unambiguous semantic descriptions, in order to obtain a viable system. A body of recent work has explored the use of formal languages in specifying component interaction protocols for interoperability checking, but lacks the practicality required by software practitioners for daily use. Faced with this, we have developed a lightweight specification approach to component interaction rules, which has the necessary expressiveness and employs event patterns in rule specification for easy adoption by practitioners. In this paper, we present a FSA-based semantic model for such rules and novel studies of rule consistency and system-wide protocol interoperability for components annotated with interaction rules. We also develop incremental approaches and tools to check these properties, which provide an effective means to discover errors in the design of component interaction rules and component-based system architectures.
Character, contact, and stigma reduction: investigating mediated contact and U.S. digital stories of opioid use disorder
Creators: name: Smith, Rachel A.
name: Osoro, Ruth A.
name: Sterner, Glenn
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Communication may play a key role in deconstructing existing stigmas. One popular initiative to reduce the stigma of opioid use disorder (OUD) is to increase contact between people in recovery and the public through digital storytelling. Why do some stories and storytellers make a more powerful impact? We drew upon the theory of character construction to offer new explanations for why mediated intergroup contact can facilitate positive intergroup outcomes. Across two studies (N = 209 and N = 191), exposure to recovery stories increased positive stereotypes and promoted future, interpersonal contact via transportation, intergroup ease, and outgroup variability. Two storyteller perceptions – fluid and multidimensional character – facilitated contact effects. The findings advance our understanding of how story content shapes a form of narrative persuasion, and its ability to improve intergroup relations.
Early Parenting Precursors of Child Developmental Outcomes: What Counts Beyond Parental Sensitivity?
Creators: name: Forrer, Mirte L.
name: de Moor, Marleen H. M.
name: Schuengel, Carlo
name: Oosterman, Mirjam
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Mental Health

description: Objective. Parental sensitivity is a precursor of child developmental outcomes, but other parental behaviors such as warmth, stimulation of cognitive development, intrusiveness, and hostility are also associated with those outcomes. The aim of the current study was to untangle unique linkages among parental sensitivity, other parental behaviors, and outcome domains deemed relevant for child welfare in an ethnically homogenous sample. Design. Data from European American dyads of the NICHD Study of Early Child Care and Youth Development (N = 1,097) across 13 waves from 6 months to 15 years of age were split into two datasets for cross validation. Twelve of 284 outcome measures were selected a priori as domain indicators. Only one measure was eligible for the domain Coping, therefore this measure and domain were omitted. Results. Confirmatory factor analysis revealed acceptable model fit for robust outcome domains of Emotional Regulation Problems, Self-Concept, and Problem Behavior assessed during childhood and adolescence. Using structural equation modeling, parental sensitivity statistically predicted Emotional Regulation Problems during primary school and Problem Behavior throughout primary school and adolescence. However, prediction in adolescence was no longer statistically significant after adding demographic confounders. Stimulation of cognitive development predicted Problem Behavior during primary school over and above parental sensitivity, yet, this effect was no longer statistically significant after adding demographic confounders. Parental intrusiveness and detachment, positive and negative regard, and flatness of affect showed no added predictive value. Conclusions. These findings may guide parsimonious assessment of the quality of the caregiving environment of young children.
title: How to develop Knowledge and Skills for Mechanization in Africa
title: Historical examples from the United States and Germany
titleType: AlternativeTitle
Creators: name: Daum, Thomas
name: Huffman, Wallace E.
name: Birner, Regina
Publisher: name: Center for Development Research (ZEF)
Year: 2018
Subjects: subject: Africa
subject: Skill development
subject: Agricultural production
subject: Crops
subject: Mechanization
subject: ddc:370
subject: ddc:630

description: Agricultural mechanization is now high on the policy agenda of many African countries, yet few of these efforts emphasize the development of knowledge and skills. However, without the appropriate knowledge and skills, using farm machinery is not very profitable. For example, the International Food Policy Research Institute (IFPRI) found that more than 80% of the tractor-owners in Ghana regularly face long breakdowns of their equipment due to a lack of knowledge and skills on adequate operation and maintenance. A look into history shows that fully mechanized countries such as the United States of America and Germany once faced similar problems. This policy brief analyses how the United States and Germany built up the knowledge and skills needed for successful mechanization and derives insights that are relevant for developing countries.
Effects of a Baby Carrier Intervention on Fathers’ Sensitivity, Involvement, and Hormonal Levels: Follow-Up of a Randomized Controlled Study
Creators: name: Witte, Annemieke M.
name: de Moor, Marleen H. M.
name: Verhees, Martine W. F. T.
name: Lotz, Anna M.
name: van IJzendoorn, Marinus H.
name: Bakermans-Kranenburg, Marian J.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Objective. Fathers are of great importance for healthy child development. This randomized controlled study investigated the longer-term effects of an intervention using a soft baby carrier on fathers’ observed sensitive caregiving, involvement, and oxytocin and cortisol levels. Design. First-time fathers were randomly assigned to use a baby carrier (n = 41) or baby seat (n = 39) and were asked to use the carrier or seat for at least 6 h per week for 3 weeks. Pretest (Mchild age = 2.67 months), posttest (Mchild age = 3.99 months), and follow-up (Mchild age = 8.25 months) father data were collected. Results. No intervention effects of baby carrier use on fathers’ sensitivity, involvement, and oxytocin or cortisol levels at follow-up emerged. Unexpectedly, fathers in the baby seat condition reported an increase in the amount of time spent with the infant. Fathers’ sensitivity and oxytocin levels decreased over time, while cortisol levels increased over time, irrespective of condition. Conclusions. This study showed less optimal hormonal levels in fathers over time, suggesting that support during the first months of fatherhood is needed. Furthermore, use of a baby seat may have contributed to fathers enjoying their time with their infant and consequently their involvement in child caregiving.
The origin of Mīmāṃsā as a school of thought: a hypothesis
Creators: name: Bronkhorst, Johannes
Publisher: name: Zenodo
Year: 2001

description: Johannes Bronkhorst, "The origin of Mīmāṃsā as a school of thought: a hypothesis," Vidyārṇavavandanam: Essays in Honour of Asko Parpola, Studia Orientalia 94, edited by Klaus Karttunen and Petteri Koskikallio (Helsinki, 2001): 83-103.
Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of Cannabis sativa
Creators: name: Singh, Ruhi
name: Singh, Bikram
name: Singh, Ajay
name: Rana, Shivani
name: Sharma, Kirti
name: Viswakarma, Pooja
name: Gopu, Boobalan
name: Nalli, Yedukondalu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: A new, canniprene B (4), along with five known (1–3 and 5–6) dihydrostilbenes were isolated from the leaves of Cannabis sativa collected at CSIR – IIIM, Jammu, India. Structures of all isolated compounds were elucidated by spectroscopic data analysis, including 1D and 2D NMR, and HR-ESI-MS. Canniprene B is a new prenylated dihydrostilbenes, a positional isomer of the known compound canniprene (5). The cytotoxic activities of these compounds (1–6) were evaluated using the SRB assay against a panel of five human cancer cell lines. Notably, canniprene B (4) exhibited varying levels of cytotoxicity with IC50 values ranging from 2.5 to 33.52 μM, demonstrating the most potent activity against pancreatic cancer cells.
La gradualità nella formazione in ambito sanitario
Creators: name: Parisi, Giuseppe
Publisher: name: Tutor
Year: 2024

description: Descrizione del simposio


L'attuale carenza di personale sanitario ha portato notevoli cambiamenti nei percorsi di formazione post-laurea, sia nelle specializzazioni universitarie cliniche/chirurgiche e servizi che nei corsi regionali per medicina generale. La necessità di poter avere forza-lavoro in tempi ristretti ha portato ad una contrazione del tempo di formazione classicamente inteso, quello in cui c’era un periodo di tirocini e seminari che avevano il fine di conferire l'acquisizione delle competenze e una gradualità nell’autonomia decisionale delle responsabilità professionali. Oggi, un medico specializzando a partire dal 2° anno può essere assunto durante la specializzazione (gazzetta del 15/06/2023), così come un medico in formazione specifica può già essere incaricato dal SSN dal 1° anno di corso per gestire un ambulatorio di medicina generale (con massimo 1000 pazienti). Questa nuova prassi emergenziale -prassi educativa- ci invita quindi a dover rivalutare gli equilibri gerarchici formazione-lavoro. Dal punto di vista pedagogico è quindi fondamentale chiedersi come applicare il principio di gradualità nello sviluppo professionale e nella certificazione delle competenze del professionista?


 


Obiettivo del simposio:


Discutere e analizzare come dovrebbero cambiare i modelli pedagogici alla luce del cambio radicale dell’esperienza formativa post-laurea da un’esperienza per steps annuali di formazione al lavoro con tutoraggio e certificazione finale che sancisce l’autonomia alle responsabilità specialistiche vs formazione-lavoro nella quale v’è una contrazione del tempo di tutoraggio e un’assunzione di autonomia della responsabilità professionali durante la formazione e prima che venga rilasciato il titolo di specialista.


 
description: Tutor, V. 23 N. 2
Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B
Creators: name: Navarrete, Karen R.
name: Alderete, Joel B.
name: Jiménez, Verónica A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Using molecular modeling, we have investigated the structure and dynamic properties of epothilone B–tubulin complexes with wild-type and mutated tubulin, aimed at identifying the molecular factors involved in the emergence of drug resistance induced by four protein mutations at Phe270Val, Thr274Ile, Arg282Gln, and Gln292Glu. Our results revealed that tubulin mutations render significant changes in the protein conformation in regions involved either in the binding of the ligand or in interdimer contacts that are relevant to the assembly of stable microtubules. In addition, point mutations induce drastic changes in the binding pose of the ligand and in the interaction networks responsible for the epothilone–tubulin association. Large ligand displacements inside the binding pocket and an overall decrease in the strength of drug-receptor polar contacts suggest a looser binding of the ligand in tubulin mutants. These results explain the loss of activity for epothilone B against cancer cells that contain tubulin mutants and provide valuable information to enhance the understanding of the atomic source of epothilones’ activity, which can be helpful to conduct further research on the rational design of more potent therapeutic tubulin-binding agents.
A process framework for characterising security properties of component-based software systems
Creators: name: Khan, Khaled M.
name: Han, Jun
Publisher: name: Swinburne
Year: 2024

description: We present a security characterisation process framework for software components and their compositions in order to address the issue of trust in component based software. The process is based on the idea of publishing trust related properties of software components in machine readable as well as understandable form at the component level and incorporating such properties with runtime composition of the application system. We explore the actual process involved in specifying publishable security properties of atomic components, component certification, reasoning about compositional security contracts, and characterising ultimate systems-level security properties to inspire trust in software components.
Nuevos métodos híbridos de computación flexible para clasificación multietiqueta
Creators: name: Charte, Francisco
Publisher: name: figshare
Year: 2015
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: Computer Engineering
subject: Applied Computer Science

description: This is my Ph.D. thesis / Esta es mi tesis doctoral
Tree species diversity and abundance in coffee farms adjacent to areas of different disturbance histories in Mabira forest system, central Uganda
Creators: name: Gwali, Samson
name: Agaba, Hillary
name: Balitta, Paul
name: Hafashimana, David
name: Nkandu, Joseph
name: Kuria, Anne
name: Pinard, Fabrice
name: Sinclair, Fergus
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Coffee production in Uganda is done on small-scale farms containing a very significant tree component. However, there is little information on how tree species abundance, richness and diversity change in coffee farms as distance from forest changes. The main objectives of this study, therefore, were to assess (a) abundance and (b) diversity of tree species in the coffee production systems in proximity to disturbed and undisturbed forest around Mabira forest, one of Uganda’s Robusta coffee-growing areas. Seventy-nine 0.1 ha plots were established in nine villages close to undisturbed and disturbed forest, and over 5 km from the forest. A total of 875 trees belonging to 63 species were recorded. There was significant similarity in species composition among the three study sites (analysis of similarity R = 0.09, p F3,12 = 0.353, p = 0.79). Non-metric dimensional scaling supported these findings (stress value = 0.224 at k = 2) and showed that tree species composition in the three proximity categories was very similar. These results demonstrate that tree species composition and diversity is similar in coffee farms regardless of their distance from the nearest natural forest and forest exploitation history.
Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modelling study on native and mutated tubulin complexes with epothilone B
Creators: name: Navarrete, Karen R.
name: Alderete, Joel B.
name: Jiménez, Verónica A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Using molecular modelling we have investigated the structure and dynamic properties of epothilone B-tubulin complexes with wild-type and mutated tubulin, aimed at identifying the molecular factors involved in the emergence of drug resistance induced by four protein mutations at Phe270Val, Thr274Ile, Arg282Gln and Gln292Glu. Our results revealed that tubulin mutations render significant changes in the protein conformation in regions involved either in the binding of the ligand or in interdimer contacts that are relevant to the assembly of stable microtubules. In addition, point mutations induce drastic changes in the binding pose of the ligand and in the interaction networks responsible for the epothilone-tubulin association. Large ligands displacements inside the binding pocket and an overall decrease in the strength of drug-receptor polar contacts suggest a looser binding of the ligand in tubulin mutants. These results explain the loss of activity for epothilone B against cancer cells that contain tubulin mutants and provide valuable information to enhance the understanding of the atomic source of epothilones’ activity, which can be helpful to conduct further research on the rational design of more potent therapeutic tubulin-binding agents.
Glaciological and geomorphological map of Glacier Noir and Glacier Blanc, French Alps
Creators: name: Lardeux, Pierre
name: Glasser, Neil
name: Holt, Tom
name: Hubbard, Bryn
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: This paper presents and describes a glaciological and geomorphological map of Glacier Noir and Glacier Blanc, French Alps. Glacier Noir is a debris-covered glacier and is adjacent to Glacier Blanc, a clean-ice (debris-free) glacier. The glaciological and geomorphological evolution of Glacier Blanc is well known, but the evolution of Glacier Noir is poorly understood, as is the case for many debris-covered glaciers globally, despite their importance in a number of mountain ranges around the world (e.g. European and Southern Alps, the Himalayas and the Rockies). The accompanying map was created by manually digitising aerial ortho-images and historical georeferenced photographs from 1952 to 2013. The main glacial and geomorphological features of both glaciers were mapped, including debris cover, crevasses, moraines, hummocky terrain and scree areas. Hydrological features (supra- and pro-glacial streams and meltwater ponds) were also mapped. The map illustrates the key differences between Glacier Noir and Glacier Blanc, and is important for understanding future glaciological and geomorphological changes.
Glaciological and geomorphological map of Glacier Noir and Glacier Blanc, French Alps
Creators: name: Lardeux, Pierre
name: Glasser, Neil
name: Holt, Tom
name: Hubbard, Bryn
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: This paper presents and describes a glaciological and geomorphological map of Glacier Noir and Glacier Blanc, French Alps. Glacier Noir is a debris-covered glacier and is adjacent to Glacier Blanc, a clean-ice (debris-free) glacier. The glaciological and geomorphological evolution of Glacier Blanc is well known, but the evolution of Glacier Noir is poorly understood, as is the case for many debris-covered glaciers globally, despite their importance in a number of mountain ranges around the world (e.g. European and Southern Alps, the Himalayas and the Rockies). The accompanying map was created by manually digitising aerial ortho-images and historical georeferenced photographs from 1952 to 2013. The main glacial and geomorphological features of both glaciers were mapped, including debris cover, crevasses, moraines, hummocky terrain and scree areas. Hydrological features (supra- and pro-glacial streams and meltwater ponds) were also mapped. The map illustrates the key differences between Glacier Noir and Glacier Blanc, and is important for understanding future glaciological and geomorphological changes.
A Security Characterisation Framework for Trustworthy Component Based Software Systems
Creators: name: Khan, Khaled Md
name: Han, Jun
Publisher: name: Swinburne
Year: 2024

description: This paper explores how to characterize security properties of software components, and how to reason about their suitability for a trustworthy compositional contract. Our framework provides an explicit opportunity for software composers as well as software components to test a priori security properties of software components in a system composition. The proposed framework uses logic programming as a tool to represent security properties of atomic components and reason about their compositional matching with other components. This enables software components as well as composers to 'test' possible matches and mismatches between the security properties of the candidate components and the security requirements of the enclosing applications systems.
pH effects of the addition of three biochars to acidic Indonesian mineral soils
Creators: name: V Martinsen
name: V Alling
name: NL Nurida
name: J Mulder
name: SE Hale
name: C Ritz
name: DW Rutherford
name: A Heikens
name: GD Breedveld
name: G Cornelissen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Meta Science
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Soil acidity may severely reduce crop production. Biochar (BC) may increase soil pH and cation exchange capacity (CEC) but reported effects differ substantially. In a systematic approach, using a standardized protocol on a uniquely large number set of 31 acidic soils, we quantified the effect of increasing amounts (0–30%; weight:weight) of three types of field-produced BCs (from cacao (Theobroma cacao. L.) shell, oil palm (Elaeis guineensis. Jacq.) shell and rice (Oryza sativa. L.) husk) on soil pH and CEC. Soils were sampled from croplands at Java, Sumatra and Kalimantan, Indonesia. All BCs caused a significant increase in mean soil pH with a stronger response and a greater maximum increase for the cacao shell BC addition, due to a greater acid neutralizing capacity (ANC) and larger amounts of extractable base cations. At 1% BC addition, corresponding to about 30 tons ha−1, the estimated increase in soil pH from the initial mean pH of 4.7 was about 0.5 units for the cacao shell BC, whereas this was only 0.05 and 0.04 units for the oil palm shell and rice husk BC, respectively. Besides depending on BC type, the increase in soil pH upon the addition of each of the three BCs was mainly dependent on soil CEC (low CEC resulting in stronger pH increase), and to a lesser extent on initial soil pH (higher initial pH resulting in stronger pH increase). Addition of BC also increased the amount of exchangeable base cations (cacao shell ≫ oil palm and rice husk) and CEC. Through this systematic screening of the effect of BC on pH and CEC of acidic soils, we show that a small addition of BC, in particular if made of cacao shell, to acidic agricultural soils increases soil pH and CEC. However, the response is highly dependent on the type, quality and amount of the added BC as well as on intrinsic soil properties, mainly CEC.
Tree species diversity and abundance in coffee farms adjacent to areas of different disturbance histories in Mabira forest system, central Uganda
Creators: name: Gwali, Samson
name: Agaba, Hillary
name: Balitta, Paul
name: Hafashimana, David
name: Nkandu, Joseph
name: Kuria, Anne
name: Pinard, Fabrice
name: Sinclair, Fergus
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences

description: Coffee production in Uganda is done on small-scale farms containing a very significant tree component. However, there is little information on how tree species abundance, richness and diversity change in coffee farms as distance from forest changes. The main objectives of this study, therefore, were to assess (a) abundance and (b) diversity of tree species in the coffee production systems in proximity to disturbed and undisturbed forest around Mabira forest, one of Uganda’s Robusta coffee-growing areas. Seventy-nine 0.1 ha plots were established in nine villages close to undisturbed and disturbed forest, and over 5 km from the forest. A total of 875 trees belonging to 63 species were recorded. There was significant similarity in species composition among the three study sites (analysis of similarity R = 0.09, p F3,12 = 0.353, p = 0.79). Non-metric dimensional scaling supported these findings (stress value = 0.224 at k = 2) and showed that tree species composition in the three proximity categories was very similar. These results demonstrate that tree species composition and diversity is similar in coffee farms regardless of their distance from the nearest natural forest and forest exploitation history.
Servizio di Aiuto Psicologico (SAP) del CdL di Medicina e Chirurgia dell’Università di Torino: primi risultati a 2 anni dall’apertura
Creators: name: Stefan, Andreea Beatrice
name: Trioni, Jacopo
name: Soro, Giovanna
name: Olivero, Alberto
name: Miniotti, Marco
name: Leombruni, Paolo
Publisher: name: Tutor
Year: 2024

description: Servizio di Aiuto Psicologico (SAP) del CdL di Medicina e Chirurgia dell’Università di Torino: primi risultati a 2 anni dall’apertura
description: Tutor, V. 23 N. 2
Evaluation of tomato (Lycopersicon lycopersicum Mill.) for fruit yield and yield components in the southern Guinea Savanna ecology of Nigeria
Creators: name: Iqbal, Zahid
Publisher: name: figshare
Year: 2015
Subjects: subject: Soil Science
subject: Education
subject: Botany
subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: Environmental Science
subject: Genetics
subject: FOS: Biological sciences

description: Field experiments were conducted at the Teaching and Research Farm of the University of Agriculture, Makurdi during the 2010 and 2011 rain fed cropping season with the objective of evaluating the performance of tomato varieties in the Southern Guinea Savanna ecology of Nigeria. The experimental design was a randomised complete block design with three replications while four varieties of tomato namely Roma Savanna VF (an improved variety), two hybrid varieties (F1 Lindo and F1 Jaguar) and a local variety (Local check) constituted the treatments. Highly significant variety effect was observed for all the traits (days to flowering, fruit length, fruit diameter, number of fruit s/plant, weight of fruits/plant and fruit yield) studied, indicating that the varieties evaluated are genetically diverse. The highest values for fruit length, fruit diameter, number of fruit s/plant, weight of fruits/plant and fruit yield observed for Roma Savanna VF is an indication that this variety has the potential for good performance in the southern guinea savanna ecology of Nigeria. Further studies on multi-locational evaluation of Roma savana VF along with more varieties including the local variety (local check) is required prior to the recommendation of Roma savana VF for adoption in the southern Guinea Savanna ecology of Nigeria.