cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Erinnerungssysteme zur Erhöhung der Impfrate gegen saisonale Influenza bei Risikopatienten - Eine Befragung niedergelassener Ärzte
Creators: name: Wortberg, S.
name: Walter, Dietmar
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2010
Subjects: subject: Influenzaimpfung
subject: Erinnerungssystem
subject: niedergelassene Ärzte
subject: Risikopatienten
subject: 610 Medizin

description: Hintergrund und Fragestellung: Eine Erkrankung an saisonaler Influenza stellt insbesondere für ältere Menschen und chronisch Kranke eine erhebliche gesundheitliche Bedrohung dar. Die vorliegende Studie untersuchte, in welchem Umfang und welcher Form Erinnerungssysteme bei niedergelassenen Internisten, Allgemeinmedizinern und Pädiatern zur Steigerung der Impfquote gegen Influenza von Risikopatienten eingesetzt werden. Darüber hinaus wurden der Impfstatus der Niedergelassenen, die Einstellungen bezüglich der Gefährlichkeit der Influenza sowie der Effektivität der Influenzaimpfung und mögliche Zusammenhänge zum Einsatz von Erinnerungssystemen untersucht. Methoden: Die Befragung wurde mittels Telefoninterviews durchgeführt. Befragt wurden 700 Ärzte, davon 445 Allgemeinmediziner, 180 Internisten und 75 Pädiater. Ergebnisse: Der Anteil der befragten Ärzte, die ein Erinnerungssystem einsetzen, liegt insgesamt bei 25 % (West 31 %, Ost 12 %). Am verbreitetsten sind telefonische Erinnerungen (40 %), gefolgt von persönlichen Erinnerungen (21 %), schriftlichen Erinnerungen (17 %) und elektronischen Erinnerungen (2 %). Die Mehrheit der befragten Ärzte gibt an, regelmäßig geimpft (70 %) zu sein, 14 % seien unregelmäßig und 16 % nie geimpft. Bei westdeutschen Niedergelassenen besteht ein deutlicher Zusammenhang zwischen Impfstatus und Erinnerungssystem: Ist der Arzt regelmäßig selbst immunisiert, steigt der Anteil der Praxen mit Erinnerungssystem von 18 % (bei Ärzten, die nie gegen Influenza geimpft sind) auf 37 %. 85 % der Ärzte mit Erinnerungssystem sagen, dass die Impfquote der Patienten durch den Einsatz gesteigert wurde. Folgerung: Der vermehrte Einsatz von Erinnerungssystemen in der niedergelassenen Praxis kann dazu beitragen, die Durchimpfung von Risikopatienten gegen saisonale Influenza zu steigern.
Additional file 1 of Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs
Creators: name: Bamford, Emma
name: Berntsson, Hannah
name: Beale, Suzanne
name: Desoysa, Lauren
name: Dias, Joseph
name: Hamer-Kiwacz, Sienna
name: Hind, Daniel
name: Johnson, Nick
name: Loban, Amanda
name: Molloy, Kaye
name: Morvan, Emma
name: Rombach, Ines
name: Selby, Anna
name: Thokala, Praveen
name: Turtle, Chris
name: Walters, Stephen
name: Drummond, Avril
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Additional file 1. FIRST Study Sites
Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?
Creators: name: Denner, Joachim
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin

description: Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs. Xenotransplantation is being developed in order to alleviate the reduced availability of human organs. Despite the fact that PERVs are able to infect certain human cells and cells from other species, transmission of PERVs has not been observed when animals (including non-human primates) were inoculated with PERV preparations or during preclinical xenotransplantations. The data indicate that PERVs were not transmitted because they were not released from the transplant or were inhibited by intracellular restriction factors and innate immunity in the recipient. In a single study in guinea pigs, a transient PERV infection and anti-PERV antibodies were described, indicating that in this case at least, the immune system may also have been involved.
Additional file 2 of Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs
Creators: name: Bamford, Emma
name: Berntsson, Hannah
name: Beale, Suzanne
name: Desoysa, Lauren
name: Dias, Joseph
name: Hamer-Kiwacz, Sienna
name: Hind, Daniel
name: Johnson, Nick
name: Loban, Amanda
name: Molloy, Kaye
name: Morvan, Emma
name: Rombach, Ines
name: Selby, Anna
name: Thokala, Praveen
name: Turtle, Chris
name: Walters, Stephen
name: Drummond, Avril
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Additional file 2.
Characterization of attaching and effacing Escherichia coli (AEEC) isolated from pigs and sheep
Creators: name: Fröhlicher, Erik
name: Krause, Gladys
name: Zweifel, Claudio
name: Beutin, Lothar
name: Stephan, Roger
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2008
Subjects: subject: Animals
subject: DNA
subject: Feces/microbiology
subject: Adhesins
subject: Bacterial/genetics
subject: Disease Reservoirs/veterinary
subject: Escherichia coli/classification
subject: Escherichia coli/genetics
subject: Escherichia coli/isolation & purification
subject: Escherichia coli/pathogenicity
subject: Escherichia coli Infections/microbiology
subject: Escherichia coli Infections/veterinary
subject: Escherichia coli Proteins/genetics
subject: Serotyping
subject: Sheep/microbiology
subject: Sheep Diseases/microbiology
subject: Swine/microbiology
subject: Swine Diseases/microbiology
subject: 610 Medizin

description: Background: Attaching and effacing Escherichia coli (AEEC) are characterized by their ability to cause attaching-and-effacing (A/E) lesions in the gut mucosa of human and animal hosts leading to diarrhoea. The genetic determinants for the production of A/E lesions are located on the locus of enterocyte effacement (LEE), a pathogenicity island that also contains the genes encoding intimin (eae). This study reports data on the occurrence of eae positive E. coli carried by healthy pigs and sheep at the point of slaughter, and on serotypes, intimin variants, and further virulence factors of isolated AEEC strains. Results: Faecal samples from 198 finished pigs and 279 sheep were examined at slaughter. The proportion of eae positive samples was 89% for pigs and 55% for sheep. By colony dot-blot hybridization, AEEC were isolated from 50 and 53 randomly selected porcine and ovine samples and further characterized. Strains of the serotypes O2:H40, O3:H8 and O26:H11 were found in both pigs and sheep. In pigs O2:H40, O2:H49, O108:H9, O145:H28 and in sheep O2:H40, O26:H11, O70:H40, O146:H21 were the most prevalent serotypes among typable strains. Eleven different intimin types were detected, whereas γ2/θ was the most frequent, followed by β1, ε and γ1. All but two ovine strains tested negative for the genes encoding Shiga toxins. All strains tested negative for the bfpA gene and the EAF plasmid. EAST1 (astA) was present in 18 of the isolated strains. Conclusion: Our data show that pigs and sheep are a source of serologically and genetically diverse intimin-harbouring E. coli strains. Most of the strains show characteristics of atypical enteropathogenic E. coli. Nevertheless, there are stx-negative AEEC strains belonging to serotypes and intimin types that are associated with classical enterohaemorrhagic E. coli strains (O26:H11, β1; O145:H28, γ1).
STUDIO DEL CALCIUM SENSING RECEPTOR E POSSIBILE RUOLO NELLA CALCOLOSI RENALE DI CALCIO
Creators: name: ALOIA, ANDREA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Background: The calcium-sensing receptor (CaSR) is a candidate gene of calcium nephrolithiasis. Previously, studies found an association between the CaSR gene region including P1 and P2 promoters and calcium nephrolithiasis. Particularly, the rs7652589 and rs1501899 SNPs, localized up and downstream of promoters, were associated to calcium nephrolithiasis in normocitraturic patients with a p-value of 0.0009 and 0.0004 respectively.
The aims of this study were to identified some other CaSR gene promoter SNPs in CaSR promoter region associated with calcium nephrolithiasis and to test their effects on CaSR expression in tubular kidney tissue. Methods: By bioinformatic approch, SNPs were selected as located in P1 or P2 or modifing transcription factors binding sites. SNPs genotyping was performed by Taqman genotyping assays of rs7648041, rs7648044, rs6776158 and rs1048213 in 167 idiopathic calcium stone formers and 213 healthy controls, matched for age, bodi mass index and gender. In 109 normal kidney medulla tissues CaSR mRNA level was evaluated by real-time PCR and SNPs associated to calcium nephrolithiasis (rs7652589, rs1501899 and rs6776158) were genotyped. The influence of rs6776158 SNP on P1 transcription regulation was tested by luciferase assay. Results: A fine mapping of the CaSR gene promoter region has been performed to identify SNPs with a possible role in CaSR gene regulation. In stone formers and, controls, SNPs localized in CaSR regolatory were genotyped. The data showed that SNP rs6776158, localized in P1 (159 bp upstream the transcription start site), resulted associated with the disease. Particularly, rs6776158 minor allele showed a higher frequency in stone formers than in controls (37.8% vs 26.4%, p=0.00084). The homozygous people for polimorfic allele have a risk to develop the disease 3 times higher than other genotypes (O.R.=2.968). CaSR mRNA was measured in kidney medulla tissues and was related to the kidney stones associated SNPs. A decreased CaSR mRNA was found in homozygous subjects for the minor allele of rs6776158 and rs1501899 vs heterozygous and homozygous for the common allele (rs6776158: n=95, 2.753�0.22 vs n=14, 1.69�0.33, p=0.0157; rs1501899: n=95, 2.753�0.22 vs n=14, 1.69�0.33, p=0.0157). No variation was found with rs7652589. In HEK-293 and HKC-8 cells, luciferase assays confirmed that rs6776158 polimorfic allele decrease the P1 activity. Conclusions: These findings confirmed the association of calcium nephrolithiasis with CaSR promoter region. Particularly, the polimorfic allele rs6776158 was more frequent in stone formers than in controls. Moreover, omozigous subjet for the polimorfic allele have a risk 3 times higher to show the disease and a reduction of kidney CaSR mRNA expression. For this reason we hypothesize that a reduction of CaSR expression can predispose to calcium nephrolithiasis.
Cowpox Virus Outbreak in Banded Mongooses (Mungos mungo) and Jaguarundis (Herpailurus yagouaroundi) with a Time-Delayed Infection to Humans
Creators: name: Kurth, Andreas
name: Straube, Martin
name: Kuczka, Annette
name: Dunsche, Anton Josef
name: Meyer, Hermann
name: Nitsche, Andreas
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2009
Subjects: subject: Humans
subject: Phylogeny
subject: Female
subject: Polymerase Chain Reaction
subject: Disease Outbreaks
subject: Male
subject: Animals
subject: Microscopy
subject: Time Factors
subject: Cowpox/transmission
subject: Zoonoses/epidemiology
subject: Zoonoses/transmission
subject: Risk
subject: Electron
subject: Rats
subject: Cowpox/epidemiology
subject: Cowpox virus/metabolism
subject: Felidae
subject: Herpestidae
subject: 610 Medizin

description: Background: Often described as an extremely rare zoonosis, cowpox virus (CPXV) infections are on the increase in Germany. CPXV is rodent-borne with a broad host range and contains the largest and most complete genome of all poxviruses, including parts with high homology to variola virus (smallpox). So far, most CPXV cases have occurred individually in unvaccinated animals and humans and were caused by genetically distinguishable virus strains. Methodology/Principal Findings: Generalized CPXV infections in banded mongooses (Mungos mungo) and jaguarundis (Herpailurus yagouaroundi) at a Zoological Garden were observed with a prevalence of the affected animal group of 100% and a mortality of 30%. A subsequent serological investigation of other exotic animal species provided evidence of subclinical cases before the onset of the outbreak. Moreover, a time-delayed human cowpox virus infection caused by the identical virus strain occurred in a different geographical area indicating that handling/feeding food rats might be the common source of infection. Conclusions/Significance: Reports on the increased zoonotic transmission of orthopoxviruses have renewed interest in understanding interactions between these viruses and their hosts. The list of animals known to be susceptible to CPXV is still growing. Thus, the likely existence of unknown CPXV hosts and their distribution may present a risk for other exotic animals but also for the general public, as was shown in this outbreak. Animal breeders and suppliers of food rats represent potential multipliers and distributors of CPXV, in the context of increasingly pan-European trading. Taking the cessation of vaccination against smallpox into account, this situation contributes to the increased incidence of CPXV infections in man, particularly in younger age groups, with more complicated courses of clinical infections.
Teorie e pratiche dello storytelling organizzativo. Applicabilit� di modelli di comunicazione narrativa a imprese ed istituzioni: stabilizzazione metodologico-disciplinare e sviluppo operativo
Creators: name: CERUTTI, Dario
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2020

description: La tesi si colloca nel contesto di un Apprendistato di Alta formazione e ricerca, un percorso triennale orientato allo sviluppo sinergico di competenze di ricerca e di competenze operativo-professionali. I caratteri della formula prevedono il coinvolgimento di un soggetto privato proponente e di un?istituzione universitaria, i quali stabiliscono in modo condiviso motivazioni, contenuti ed obiettivi del progetto formativo. Le modalit� di svolgimento rappresentano un presupposto interpretativo utile alla comprensione della vocazione marcatamente operativa del lavoro, che ha il suo obiettivo privilegiato nel tentativo di far convergere sapere (umanistico) e saper-fare.
Oggetto dello studio � un?indagine pratico-teorica sulle strategie e sui meccanismi di comunicazione ad approccio narrativo che le organizzazioni complesse mettono in atto in diverse aree d?intervento e con diverse finalit� strategiche: posizionare un brand, trasmettere valori, suscitare empatia ed emozioni, suggerire comportamenti d?acquisto, gestire le risorse umane?
Tale argomento � di norma associato all?ampia ed inclusiva nozione di Organizational Storytelling, termine nel quale possiamo includere un insieme assai eterogeneo di pratiche creative e performative adottate da imprese o istituzioni e basate su un approccio narrativo alla realt�.
Obiettivo ad ampio raggio del lavoro di tesi pu� essere considerato la stabilizzazione metodologica e concettuale della nozione e la sistematizzazione del suo uso in ambito organizzativo.
Da un punto di vista strutturale, il discorso di tesi appare diviso in due macrosettori complementari: una prima parte di analisi teorico-formale, ed una seconda parte pi� rispondente alla vocazione operativa del progetto, dedicata cio� alla descrizione di casi-studio in cui le proposte formalizzate in precedenza hanno trovato concreta applicazione.
title: Too Pretty for Homework
title: The Academic Correlates of Sexualized Gender Stereotypes Among Adolescent Girls
titleType: Subtitle
Creators: name: Nelson, Andrew A.
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Developmental Psychology
subject: Social Psychology

description: Girls grow up in a culture of ubiquitous female sexualization, and this culture propagates stereotypes that could interfere with their academic outcomes. The current study examined the academic correlates of these sexualized gender stereotypes (SGS) among early adolescent girls. Girls (N = 99) aged 11 to 14 (Mage = 12.4 years, SD = .57 years) completed a survey assessing their academic performance, attitudes, and beliefs. The survey also assessed the degree to which girls believed that boys and girls should act in accordance with these sexualized gender stereotypes. Results indicated that higher endorsement of sexualized gender stereotypes was associated with lower academic performance, more negative academic attitudes, and less adaptive approaches to learning. Implications for girls’ academic trajectories are discussed.
Nasal Colonization of Humans with Methicillin-Resistant Staphylococcus aureus (MRSA) CC398 with and without Exposure to Pigs
Creators: name: Cuny, Christiane
name: Nathaus, Rolf
name: Layer, Franziska
name: Strommenger, Birgit
name: Witte, Wolfgang
name: Altmann, Doris
Publisher: name: Robert Koch-Institut; Robert Koch-Institut, Infektionskrankheiten / Erreger; Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: 610 Medizin

description: Background: Studies in several European countries and in North America revealed a frequent nasal colonization of livestock with MRSA CC398 and also in humans with direct professional exposure to colonized animals. The study presented here addresses the question of further transmission to non exposed humans. Methods: After selecting 47 farms with colonized pigs in different regions of Germany we sampled the nares of 113 humans working daily with pigs and of their 116 non exposed family members. The same was performed in 18 veterinarians attending pig farms and in 44 of their non exposed family members. For investigating transmission beyond families we samples the nares of 462 pupils attending a secondary school in a high density pig farming area. MRSA were detected by direct culture on selective agar. The isolates were typed by means of spa-sequence typing and classification of SCCmec elements. For attribution of spa sequence types to clonal lineages as defined by multi locus sequence typing we used the BURP algorithm. Antibiotic susceptibility testing was performed by microbroth dilution assay. Results: At the farms investigated 86% of humans exposed and only 4.3% of their family members were found to carry MRSA exhibiting spa-types corresponding to clonal complex CC398. Nasal colonization was also found in 45% of veterinarians caring for pig farms and in 9% of their non exposed family members. Multivariate analysis revealed that antibiotic usage prior to sampling beard no risk with respect to colonization. From 462 pupils only 3 were found colonized, all 3 were living on pig farms. Conclusion: These results indicate that so far the dissemination of MRSA CC398 to non exposed humans is infrequent and probably does not reach beyond familial communities.
Towards the Standardization of the Dark/Light Transition Test with Danio rerio embryos - Preliminary Results from an Inter-laboratory Ring Test
Creators: name: Massei, Riccardo
name: Christou, Maria
name: Schroeder, Katja
name: Ottermanns, Richard
name: Domingues, Inês
name: Pavlaki, Maria
name: Monteiro, Marta
name: Zwart, Edwin
name: Hessel, Ellen
name: Johann, Sarah
name: Knapen, Dries
name: Vergauwen, Lucia
name: Huyghe, Kato
name: Kjær, Pernille Ambus
name: Holbech, Henrik
name: Molina, Beatriz
name: Muriana, Arantza
name: Sebire, Marion
name: Lillicrap, Adam
Publisher: name: Zenodo
Year: 2024
Subjects: zebrafish
behaviour
ringtest
OECD
LMR

description: One of the most commonly utilized behavioral assays with zebrafish embryos is the dark/light transition test (DLTT). This test involves recording and quantifying the swimming activities of zebrafish eleutheroembryos under different light conditions. The DLTT lacks standardization, and guidelines have yet to be established. As a result, zebrafish laboratories employ in-house protocols to record the activity of zebrafish eleutheroembryos. Different statistical tests are employed to explain the results and analyze the output. Consequently, comparing the results across different studies becomes a challenging task and poses a potential obstacle to bring these tests to regulators. Prior to developing a universal and standard guideline, it is necessary to characterize and understand the general variation in the DLTT.
Le influenze del fascismo sull?economia aziendale e sulla regolamentazione contabile
Creators: name: AMELIO, Stefano
Publisher: name: Universit� degli studi di Bergamo
Year: 2016

description: ?Economia aziendale? and the consequent debate developed in an Italian political environment continuously characterized by Fascism from 1922 until World War II.
Also the legal rules governing financial statement has been prepared (or revised) during the Fascist period.
On this basis, the objective of the study is to investigate the role of Fascism and of corporative doctrine in the drafting of ?economia aziendale?, discipline that hardly lends itself to be translated.
Simultaneously, accounting regulation could have suffered Fascist-corporative injections worthy of attention.
More precisely, the research questions are two: (1) what are the influences of the Fascist regime and of the corporative doctrine on economia aziendale? (2) what are the influences of the fascist regime and of the corporative doctrine on accounting regulation, and in particular, on the Civil Code rules that govern the drafting of financial statement?
In the research only qualitative research methodologies have been used: literature-based analysis and critique methods and archival/historical studies methods.
The philosophical framework that best explain the answers to the research questions is the Actualism of Giovanni Gentile who presented the concept of business ethics and collective/individual interest, adopted by business administration doctrines and legal doctrines in the development of corporative ?economia aziendale? and Civil law.
The analysis conducted shows that Fascism and corporative doctrine have influenced ?economia aziendale? studies in the years considered in two aspects: (1) the theoretical identification of the company objectives; (2) new business economics areas of research. Various aspects of ?economia aziendale? were therefore influenced in actualistic optical.
In relation to the second research question, the Civil Code of 1942 does not seem to show the marks of the Fascist regime, except for some referrals to special rules in the art. 2424, 2426 and 2428 cc.
Finite Element Modeling of Bond-Zone Behavior in Reinforced Concrete
Creators: name: Seok, Seungwook
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Structural engineering

description: In reinforced concrete (RC) structures, adequate bond between the reinforcement and concrete is required to achieve a true composite system, in which reinforcing steel carries tensile stress, once concrete cracks, and concrete and reinforcing steel carry compression. Determining bond strength and required development length for shear transfer between concrete and reinforcement is an ongoing research subject in the field of reinforced concrete with advances in the concrete and reinforcement materials requiring continuous experimental efforts. Finite element analysis (FEA) provides opportunities to explore structural behavior of RC structures beyond the limitations of experimental testing. However, there is a paucity of research studies employing FEA to investigate the reinforcement-concrete bond-zone behavior and related failure mechanism. Instead, most FEA-based research associated with RC bond has centered on developing a bond (or interface) constitutive model for use in FEA that, by itself, can characterize bond-zone behavior, typically represented by the bond stress-slip displacement relationship. This class of bond models is useful for simulating the global behavior of RC structures but is limited in its ability to simulate local bond resistance for geometries and material properties that differ substantially from those used to calibrate the model. To fill this gap in research, this study proposes a finite element (FE) modeling approach that can simulate local bond-zone behavior in reinforced concrete. The proposed FE model is developed in a physics-based way such that it represents the detailed geometry of the bond-zone, including ribs on the deformed reinforcement, and force transfer mechanisms at the concrete-reinforcement interface. The explicit representation of the bond-zone enables simulation of the local concrete compression due to bearing of ribs against concrete and subsequent hoop tension in the concrete. This causes bond failure either due to local concrete crushing (leading to reinforcement pullout) or global concrete splitting. Accordingly, special attention is given to the selection and calibration of a concrete model to reproduce robust nonlinear response. The power of the proposed modeling approach is its ability to predict bond failure and damage patterns, based only on the physical and material properties of the bond area. Thus, the successful implementation and application of this approach enables the use of FEA simulation to support the development of new design specifications for bond zones that include new and improved materials.
Detection of hepatitis E virus in wild boars of rural and urban regions in Germany and whole genome characterization of an endemic strain
Creators: name: Schielke, Anika
name: Sachs, Katja
name: Lierz, Michael
name: Appel, Bernd
name: Jansen, Andreas
name: Johne, Reimar
Publisher: name: Robert Koch-Institut; Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: Animals
subject: DNA
subject: RNA
subject: Germany
subject: Geography
subject: Prevalence
subject: Molecular Sequence Data
subject: Sequence Analysis
subject: Phylogeny
subject: Genotype
subject: Cluster Analysis
subject: Endemic Diseases/veterinary
subject: Genome
subject: Viral
subject: Hepatitis E/epidemiology
subject: Hepatitis E/veterinary
subject: Hepatitis E/virology
subject: Hepatitis E virus/isolation & purification
subject: Liver/virology
subject: Polymorphism
subject: Genetic
subject: Viral/genetics
subject: Sequence Homology
subject: Nucleic Acid
subject: Sus scrofa/virology
subject: Swine Diseases/epidemiology
subject: Swine Diseases/virology
subject: 610 Medizin

description: Background: Hepatitis E is an increasingly diagnosed human disease in Central Europe. Besides domestic pigs, in which hepatitis E virus (HEV) infection is highly prevalent, wild boars have been identified as a possible source of human infection. In order to assess the distribution of HEV in the wild boar population of Germany, we tested liver samples originating from different geographical regions for the presence of the HEV genome and compared the detected sequences to animal and human HEV strains. Results: A total of 148 wild boar liver samples were tested using real-time RT-PCR resulting in an average HEV detection rate of 14.9% (95% CI 9.6–21.6). HEV was detected in all age classes and all geographical regions. However, the prevalence of HEV infection was significantly higher in rural as compared to urban regions (p < 0.001). Sequencing of the PCR products indicated a high degree of heterogenicity of the detected viruses within genotype 3 and a grouping according to their geographical origin. The whole genome sequence of an HEV isolate (wbGER27) detected in many wild boars in the federal state of Brandenburg was determined. It belongs to genotype 3i and shows 97.9% nucleotide sequence identity to a partial sequence derived from a human hepatitis E patient from Germany. Conclusion: The results indicate that wild boars have to be considered as a reservoir for HEV in Germany and that a risk of HEV transmission to humans is present in rural as well as urban regions.
L?influenza dell?opera di ?echov sulla poetica di N. Ginzburg
Creators: name: GREZINA, Yulia
Publisher: name: Universit� degli studi di Bergamo
Year: 2022

description: Natalia Ginzburg pi� volte ha dichiarato di considerare ?echov come un modello per la propria scrittura, il suo nume. L?attento studio della sua opera rivela diversi punti d?incontro con la poetica cecoviana, tra cui: tipologia dei finali, uso del dettaglio nella caratteristica dei personaggi e nella creazione dei paesaggi e dell?atmosfera, funzionamento delle comparazioni con riferimento al mondo animale, un particolare tipo di metonimie, aspirazione alla semplicit� stilistica e strutturale. In questa sede verr� condotta una breve analisi della ripresa di alcuni motivi cecoviani nell?opera della scrittrice italiana.
Design and optimization of very high voltage magnetic transformer for aerospace applications
Creators: name: Ferrer López, Andrés
Publisher: name: Zenodo
Year: 2024
Subjects: CleanAviation
CAJU
HorizonEurope
EUResearch
EUInnovation
SustainableEurope
hep
hybridelectricregionalaircraft
electricdistributiontechnologies
highvoltage
regionalaircraft
distributiontechnologies
digitaltwin
lifecycleassessment

description: Poster at XVI CEI Annual Meeting "CHALLENGES IN MICROELECTRONIC DESIGN", 9-10/5/24, Madrid, Spain
High genotypic diversity and a novel variant of human cytomegalovirus revealed by combined UL33/UL55 genotyping with broad-range PCR
Creators: name: Deckers, Merlin
name: Hofmann, Jörg
name: Kreuzer, Karl-Anton
name: Reinhard, Henrike
name: Edubio, Abigail
name: Hengel, Hartmut
name: Voigt, Sebastian
name: Ehlers, Bernhard
Publisher: name: Robert Koch-Institut, Stammzellen
Year: 2009
Subjects: subject: Animals
subject: Preschool
subject: Humans
subject: Phylogeny
subject: Sequence Homology
subject: Amino Acid
subject: Cluster Analysis
subject: Child
subject: Sensitivity and Specificity
subject: Viral Proteins/genetics
subject: Genetic Variation
subject: Polymerase Chain Reaction/methods
subject: DNA Primers/genetics
subject: Cytomegalovirus/genetics
subject: Cytomegalovirus/isolation & purification
subject: Cytomegalovirus Infections/virology
subject: Hominidae
subject: Receptors
subject: Chemokine/genetics
subject: Viral Envelope Proteins/genetics
subject: 610 Medizin

description: The known strains of human cytomegalovirus (HCMV) represent genotypic variants of a single species, and HCMV genotypic variability has been studied in order to reveal correlations between different disease patterns and the presence of certain HCMV genotypes, either as single or as multiple infections. The methods used for the detection of HCMV genotypes have not always been sophisticated enough to achieve complete comprehensiveness, mainly because only one genotype is usually detected in a certain specimen, due to primer specificity and genome copy number. To improve detection of variant HCMV genotypes in mixed infections, we developed PCR assays with degenerate primers targeting two variable HCMV genes, glycoprotein B (gB, UL55) and the G-protein-coupled receptor gene UL33. Primers were designed to bind conserved sites in the genomes of HCMV variants and great ape CMVs. To analyse if samples contained one or more HCMV genotypic variants, PCR assays were supplemented with oligonucleotides containing locked nucleic acids. This broad-range PCR methodology and subsequent sequence analysis detected all gB/UL55 and UL33 genotypic variants known to date in primary clinical specimens, but also revealed that many samples contained genotype mixtures. Importantly, a novel UL33 genotypic variant could be discovered in several specimens, and one HCMV isolate was plaque-purified containing the novel UL33 genotype and a so far undescribed variant of gB.
Additional file 1 of Efficient biosynthesis of resveratrol via combining phenylalanine and tyrosine pathways in Saccharomyces cerevisiae
Creators: name: Meng, Lijun
name: Diao, Mengxue
name: Wang, Qingyan
name: Peng, Longyun
name: Li, Jianxiu
name: Xie, Nengzhong
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Resveratrol production in various hosts. Table S2. Plasmids used in this study. Table S3. Primers used in this study. Table S4. Cell densities and resveratrol titers of strains BRT9 and BRT10 cultured in YPD medium. Figure S1. Production of resveratrol in engineered strain BR1. Standards of p-coumaric acid and resveratrol, and samples of strain BR4742 and BR1 were analyzed by HPLC. Standards were dissolved in methanol, and fermentative broths of strain BY4742 and BR1 were mixed with ethanol. Strains were cultured in YPD medium with 0.5 mmol/L p-coumaric acid for 72 h. Figure S2. Time courses of (a) resveratrol production, (b) cell growth, (c) glucose consumption, (d) ethanol concentration and (e) p-coumaric acid concentration of strains BRT2, BRT5 and BRT8 cultured in YPD medium with 20 g/L and 40 g/L glucose respectively. Error bars represent standard deviations from three independent biological experiments. Figure S3. Time courses of (a) resveratrol production, (b) cell growth, (c) glucose consumption, (d) ethanol concentration and (e) p-coumaric acid concentration of strain BRT8 cultured in different media. Error bars represent standard deviations from three independent biological experiments. Figure S4. Time course of resveratrol yield on dry cell weight when strain BRT8 was cultured in YPD or minimal medium. DCW: dry cell weight. Error bars represent standard deviations from three independent biological experiments. Figure S5. Time course of p-coumaric acid concentration of strains BRT8, BRT9 and BRT10 cultured in minimal medium. 0.5 g/L lysine was added in the minimal medium for the growth of strain BRT8 and BRT9. Error bars represent standard deviations from three independent biological experiments. Figure S6. Parameters during the fed-batch fermentation in the bioreactor using the non-auxotrophic strain BRT10 in minimal medium.
L'abbandono mero degli immobili
Creators: name: Bona, Carlo
Publisher: name: Universit� di Trento. Dipartimento di scienze giuridiche
Year: 2017

description: Quello dell?abbandono mero degli immobili, o della rinuncia alla propriet� immobiliare, � un tema divenuto in tempi recenti di prepotente attualit�. Nel saggio si definisce l?istituto; se ne ripercorre l?evoluzione prendendo le mosse dal diritto antico e romano per giungere al diritto moderno dalle prime codificazioni a oggi; si chiariscono i tratti strutturali dell?istituto (abbandono come oggetto di una situazione giuridica e come atto; negozialit� e unilateralit� dell?atto di abbandono; effetti dell?abbandono e loro qualificazione) e ci si interroga sull?attuale configurabilit� dell?istituto; si indaga la disciplina dell?atto d?abbandono (legittimazione all?atto; capacit� richiesta; elementi essenziali e accidentali; invalidit�); si indagano gli effetti dell?abbandono (effetto diretto estintivo; effetti riflessi e consequenziali; effetti lesivi); ci si occupa infine dei profili pubblicitari, distinguendo le formalit� richieste nel sistema codicistico da quelle richieste nel sistema a base reale del libro fondiario.
Matisse in the Playhouse
Creators: name: E. Tavares, Elizabeth
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Shakespeare, William, 1564-1616
subject: English drama
subject: Sixteenth century
subject: Seventeenth century
subject: Dramatists
subject: Theater
subject: History

description: ON MY WAY TO EAST LONDON from a Shakespeare’s Globe perform- ance in August 2017, I noticed an advertisement in one of the Tube stations. Accompanying the billing for the Royal Academy of Arts’ exhibition, Matisse in the Studio, was a quotation from Henri: “a good actor can have a part in ten different plays; an object can play a role in ten different pictures.” It is from Museum Studies that we borrow the word curation: the selection and arrangement of pre- existing art objects for a particular experience. But this notion of curation has now overleaped the bounds of the art world; “content curation” is the stock-in-trade of every major marketing, consult- ing, and Big Data firm—from fashion to Facebook, from American Girl to the American Dream. The concept of curation, which exploded in the 1970s art world and again in the 2000s web-based economy, is much older than Matisse’s nineteenth century, how- ever. In this essay, I argue that curation is a hermeneutic equipped to account for repertory economics that structured the sixteenth- century theater industry. Pre-Shakespearean cases will exemplify how the field of Shakespeare Studies’ approach to troupes could evolve using this transdisciplinary paradigm.
An Analysis of a Pressure Compensated Control System of an Automotive Vane Pump
Creators: name: Jenkins, Ryan P
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Automotive mechatronics and autonomous systems
Mechanical engineering not elsewhere classified
Control engineering, mechatronics and robotics not elsewhere classified

description: Pressure compensated vane pump systems are an attractive solution in many automotive applications to supply hydraulic power required for cooling, lubrication, and actuation of control elements such as transmission clutches. These systems feature variable displacement vane pumps which offer reductions in parasitic loads on the engine and in wasted hydraulic energy at high engine speeds when compared to traditional fixed displacement supply pumps. However, oscillations in a currently available pressure compensation system limits the achievable performance and therefore the application of this solution.This dissertation presents the development and experimental validation of a lumped parameter model in MATLAB/Simulink of a current pressure compensated vane pump system for an automatic transmission oil supply application. An analysis of the performance of this system using the validated pump model and a developed black box control system model reveals that the low cost solenoid valve present in the control circuit to set the regulation pressure limits the achievable bandwidth to 1.84Hz and causes a significant time delay in the response. To address this limitation, as well as eliminate a non-minimum phase zero introduced by the case study’s control circuit architecture, an actively controlled electrohydraulic pressure compensation system is proposed. This proposed system is explored both experimentally and in simulation making use of the accuracy of the presented variable displacement vane pump model. Significant improvements in the achievable system performance are shown with both a simple PI control law (47% reduction in the pressure response time) and an advanced cascaded model following controller based on feedback linearization (58% reduction in the pressure response time). An analysis of these results reveals that implementing the proposed control system with a 5(L/min)/bar proportional valve with a 20Hz at ±100% (60Hz at ±50%) amplitude bandwidth and a PI control law is an economical path to achieving the best performance improvements for this automotive application.
Additional file 3 of Maximizing efficiency in sunflower breeding through historical data optimization
Creators: name: Fernández-González, Javier
name: Haquin, Bertrand
name: Combes, Eliette
name: Bernard, Karine
name: Allard, Alix
name: Isidro y Sánchez, Julio
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology

description: Additional file 3. Additional analyses and results. Note 1, methodology used for calculating the genomic relationship matrices. Note 2, additional optimization methods tested in preliminary analyses and discarded due to poor performance. Note 3, methodology for heritability and variance components calculation. Note 4, additional details of the genomic selection models used. A comparison between the two models explained in the main text and a Bayesian B model with only additive effects fitted with BGLR R package [74] is also included. Note 5, detailed overview on the use of partial least squares for PLS_CDmean. Note 6, description of TrainSel hyperparameters used and detailed discussion about computational time of optimization. Note 7, guidelines for the interpretation of the Pareto front plots in multi-objective implementation and detailed analyses for each scenario not covered in the main text. After Note 7, several figures referenced in the main text were also included.
An SMT-based framework for the formal analysis of Switched Multi-Domain Kirchhoff Networks
Creators: name: Sessa, Mirko
Publisher: name: Universit� degli studi di Trento
Year: 2019

description: Many critical systems are based on the combination of components from different physical domains (e.g. mechanical, electrical, hydraulic), and are mathematically modeled as Switched Multi-Domain Kirchhoff Networks (SMDKN).
In this thesis, we tackle a major obstacle to formal verification of SMDKN, namely devising a global model amenable to verification in the form of a Hybrid Automaton. This requires the combination of the local dynamics of the components, expressed as Differential Algebraic Equations, according to Kirchhoff's laws, depending on the (exponentially many) operation modes of the network.
We propose an automated SMT-based method to analyze networks from multiple physical domains, detecting which modes induce invalid (i.e. inconsistent) constraints, and to produce a Hybrid Automaton model that accurately describes, in terms of Ordinary Differential Equations, the system evolution in the valid modes, catching also the possible non-deterministic behaviors.
The experimental evaluation demonstrates that the proposed approach allows several complex multi-domain systems to be formally analyzed and model checked against various system requirements.
Open Digital Badges: A Solution to Improve Learning Performance and Facilitate Goal-Setting
Creators: name: Cheng, Zui
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Educational technology and computing
Other education not elsewhere classified
Higher education
Teacher education and professional development of educators

description: This dissertation consists of three journal articles about using open digital badges to improve learning performance and facilitate students’ goal setting processes. In the first study, we investigated the impact of instructional ODBs on pre-service teachers’ perceived technology capabilities and their actual learning performance in a large undergraduate technology integration course. A positive relation between using ODBs and academic learning performance was found in the study. The second study conceptually argued that the use of ODBs can positively impact learning because it helps optimize the effects of goal-setting on learning which then indirectly impacts learning performance. In the third study, we explored college students’ experiences of using ODBs as an innovative approach to facilitate their goal-setting processes in a large undergraduate technology integration course. We found that ODBs could support college students’ goal-setting processes by helping students connect different types of goals, improving goal commitment, controlling task complexity and providing prompt personalized feedback.
title: PROFESSIONAL COLLABORATION
title: THE VALUE OF MEANINGFUL CONVERSATION FOR THE STUDIO ART EDUCATOR
titleType: Subtitle
Creators: name: Bryant, Christopher L.
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Art Education

description: This thesis explores the strong support for collaboration in schools’ while synthesizing literature already conducted on the subject. The primary objectives of this thesis is to discuss possible scenarios as to why educators are not collaborating, explore characteristics and implementations of collaboration with three specific groups including colleagues, stakeholders, and practicing professionals, and identify four key benefits of collaboration which include improved health, pedagogy, autonomy, and time. Evidence supports the idea that teachers who work in isolation can hinder growth within their profession. Additional evidence provides conclusive evidence that supports the benefits of collaboration by adding responsibilities to key contributors by holding them accountable for student learning.
sj-pdf-1-anp-10.1177_00048674211025729 – Supplemental material for Life stress, sleep disturbance and depressive symptoms: The moderating role of prefrontal activation during emotion regulation
Creators: name: Lee, Kyung Hwa
name: Lee, Ha Young
name: Park, Inkyung
name: Jeon, Jeong Eun
name: Kim, Nambeom
name: Oh, Seong Min
name: Jeon, Sehyun
name: Kim, Soohyun
name: Lee, Yu Jin
name: Kim, Seog Ju
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-pdf-1-anp-10.1177_00048674211025729 for Life stress, sleep disturbance and depressive symptoms: The moderating role of prefrontal activation during emotion regulation by Kyung Hwa Lee, Ha Young Lee, Inkyung Park, Jeong Eun Jeon, Nambeom Kim, Seong Min Oh, Sehyun Jeon, Soohyun Kim, Yu Jin Lee and Seog Ju Kim in Australian & New Zealand Journal of Psychiatry
Boccaccio, Giovanni: Decameró. Maria Aurèlia Capmany (trad.)
Creators: name: Ardolino, Francesco
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Boccaccio, Giovanni, 1313-1375
subject: Translating and interpreting
subject: Europe--Catalan-speaking regions
subject: Area studies

description: Giovanni Boccaccio, Decameró, translated into Catalan by Maria Aurèlia Capmany
Additional file 1 of Screening for lung cancer with computed tomography: protocol for systematic reviews for the Canadian Task Force on Preventive Health Care
Creators: name: Pillay, Jennifer
name: Rahman, Sholeh
name: Klarenbach, Scott
name: Reynolds, Donna L.
name: Tessier, Laure A.
name: Thériault, Guylène
name: Persaud, Nav
name: Finley, Christian
name: Leighl, Natasha
name: McInnes, Matthew D. F.
name: Garritty, Chantelle
name: Traversy, Gregory
name: Tan, Maria
name: Hartling, Lisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. Responses to stakeholder reviews of the draft protocol.
O'QITUVCHI PORTFOLIOSINI YARATISH USULLARI VA VOSITALARI
Creators: name: Karamatova, Maftuna
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada oʻquv mashgʻulotlarini tashkil etish va oʻtkazishda zamonaviy yondashuvlarning mohiyati yoritilgan. Talaba markazli yondashuv, axborot-kommunikatsiya texnologiyalaridan foydalanish, faol taʼlim metodlari, baholashning yangi usullari va aralash taʼlim konsepsiyasi haqida so‘z yuritiladi. Zamonaviy metodlar o‘quvchilarning faolligini oshiradi, mustaqil fikrlash va amaliy ko‘nikmalarini rivojlantiradi. Maqolada o‘qituvchidan innovatsion fikrlash va texnologik savodxonlik talab etilishi ta’kidlangan. Taʼlim samaradorligini oshirishda ushbu yondashuvlarning ahamiyati keng tahlil etilgan.