cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Studies on the role of formyl peptide receptors in pituitary and adrenal function
Creators: name: Naughton, Vance
Publisher: name: Imperial College London
Year: 2012

description: The mechanism by which glucocorticoids (GCs) achieve negative feedback on the release of hypothalamo-pituitary-adrenal (HPA) axis hormones has long been under investigation. Annexin A1 (ANXA1) is a key mediator of the effects of GCs within the neuroendocrine and immune systems. Previous research suggested the negative feedback effect of the GC-ANXA1 system on the pituitary release of adrenocorticotrophic hormone (ACTH) was mediated via a member of the formyl peptide receptor (Fpr in rodents, FPR in humans) family. The present work tested the hypothesis that specific Fpr/FPR subtypes modulate both pituitary and adrenal function in terms of stress hormone (ACTH and corticosterone) secretion (following exposure to secretagogues CRH and ACTH or the inflammogen LPS in rats), and their tissue distribution (mice and rats) will itself be upregulated following inflammogenic stress (LPS in mice and rats, multiple sclerosis in human tissue). This was achieved through 1) immunohistochemical detection of FPR1, FPR2/ALX, and FPR3 in human anterior pituitary sections, and of green fluorescent protein (GFP) in HPA axis tissues from Fpr2/3-/-, GFP+/+ mice; 2) measurement of basal and stimulated ACTH and GC release from dispersed rat anterior pituitary and adrenal cells, incubated with agonists and antagonists for FPR1, FPR2/ALX and FPR3, namely, formyl-Met-Leu-Phe (fMLF), ANXA1 amino-acetylated peptide (ANXA1Ac2-26), Trp-Lys-Tyr-Met-Val-D-met (WKYMVm), haem-binding protein fragment (F2L), aspirin-triggered lipoxin A4 (15-epi-LXA4), and Trp-Arg-Trp-Trp-Trp-Trp (WRW4). These ligands were found to elicit a range of modulatory, concentration-dependent effects on pituitary ACTH and adrenal GC secretion. Evidence was found for the spatial distribution of: FPR3 and FPR2/ALX within the human anterior pituitary, and GFP (as a surrogate for Fpr2/3) colocalised with ACTH, growth hormone (GH), and prolactin (PRL) within the Fpr2/3-/-, GFP+/+ mouse pituitary. The findings contribute evidence in support of a role of Fpr/FPR subtypes and their ligands as modulators of pituitary and adrenal hormone release.
Phalaena caeruleocephala Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Phalaena
Phalaena caeruleocephala

description: Phalaena caeruleocephala [spec. nov.]
P. Bombyx elinguis cristata, alis deflexis griseis: macula albida duplicato didyma.
Habitat in Pomonae arboribus, florum pestis.
Larva nuda, caerulescens, luteo-lineata, nigro-punctata.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 504, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Abundances in Spiral Galaxies: Evidence for Primary Nitrogen Production
Creators: name: van Zee, L.
name: Salzer, J. J.
name: Haynes, M. P.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of nitrogen and oxygen abundance measurements for 185 HII regions spanning a range of radius in 13 spiral galaxies. As expected, the nitrogen-to-oxygen ratio increases linearly with the oxygen abundance for high metallicity HII regions, indicating that nitrogen is predominately a secondary element. However, the nitrogen-to-oxygen ratio plateaus for oxygen abundances less than 1/3 solar (12+log(O/H) < 8.45), as is also seen in low metallicity dwarf galaxies. This result suggests that the observed trend in dwarf galaxies is not due to outflow of enriched material in a shallow gravitational potential. While the effects of infall of pristine material and delayed nitrogen delivery are still unconstrained, nitrogen does appear to have both a primary and secondary component at low metallicities in all types of galaxies.
description: 10 pages, 2 figures, uses AASTex and psfig. Accepted to ApJL
Astrometric Limits on the Stochastic Gravitational Wave Background
Creators: name: Darling, Jeremy
name: Truebenbach, Alexandra E.
name: Paine, Jennie
Publisher: name: AAS
Year: 2018

description: The canonical methods for gravitational wave detection are ground- and space-based laser interferometry, pulsar timing, and polarization of the cosmic microwave background. But as has been suggested by numerous investigators, astrometry offers an additional path to gravitational wave detection. Gravitational waves deflect light rays of extragalactic objects, creating apparent proper motions in a quadrupolar (and higher-order modes) pattern. Astrometry of extragalactic radio sources is sensitive to gravitational waves with frequencies between roughly 10⁻¹⁸ and 10⁻⁸ Hz (H₀ and 1/3 yr⁻¹), overlapping and bridging the pulsar timing and CMB polarization regimes. We present a methodology for astrometric gravitational wave detection in the presence of large intrinsic uncorrelated proper motions (i.e., radio jets). We obtain 95% confidence limits on the stochastic gravitational wave background using 711 radio sources, ΩGW < 0.0064, and using 508 radio sources combined with the first Gaia data release: ΩGW < 0.011. These limits probe gravitational wave frequencies 6 × 10⁻¹⁸ Hz ≲ f ≲ 1 × 10⁻⁹ Hz. Using a WISE-Gaia catalog of 567,721 AGN, we predict a limit expected from Gaia alone of ΩGW < 0.0006, which is significantly higher than was originally forecast. Incidentally, we detect and report on 22 new examples of optical superluminal motion with redshifts 0.13–3.89.
Nondegenerate Super-Anti-de Sitter Algebra and a Superstring Action
Creators: name: Hatsuda, Machiko
name: Kamimura, Kiyoshi
name: Sakaguchi, Makoto
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct an Anti-de Sitter(AdS) algebra in a nondegenerate superspace. Based on this algebra we construct a covariant kappa-symmetric superstring action, and we examine its dynamics: Although this action reduces to the usual Green-Schwarz superstring action in flat limit, the auxiliary fermionic coordinates of the nondegenerate superspace becomes dynamical in the AdS background.
description: Latex, 12 pages, explanations added, version to be published in Phys. Rev. D
M Theory and P-Branes
Creators: name: Maharana, Jnanadeva
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Ten dimensional type IIA and IIB theories with p-branes are compactified to 8-dimensions. It is shown that resulting branes can be classified according to the representations of $\bf {SL(3,Z) \times SL(2,Z)}$. These p-branes can also be obtained by compactification of M theory on three torus and various wrappings of membrane and five brane of the eleven dimensional theory. It is argued that there is evidence for bound states of the branes in eight dimensions as is the case in the interpretation of $\bf {SL(2,Z)}$ family of string solutions obtained by Schwarz.
description: 12 pages, no figures, revtex
Ionic liquid pretreatment of lignocellulosic biomass
Creators: name: Brandt, Agnieszka
Publisher: name: Imperial College London
Year: 2011

description: This thesis is concerned with the thermal treatment of lignocellulosic biomass using ionic liquids for the purpose of comminution via dissolution, for fractionating the biological composite and for obtaining aqueous solutions of carbohydrate monomers from the pulp via enzymatic hydrolysis. A major focus was the relationship between the choice of the anion and the effectiveness of the treatment. The synthesis of a range of 1-butyl-3-methylimidazolium ionic liquids with strongly hydrogen-bond basic anions was accomplished. Selected, process-relevant physicochemical properties were measured, such as the Kamlet-Taft solvent polarity, hygroscopicity and thermal stability. It was shown that 1-butyl-3-methylimidazolium acetate is not stable at 120°C, while other ionic liquids e.g. 1-butyl-3-methylimidazolium hydrogen sulfate exhibit very good long-term thermal stability. It was shown that hydrogen-bond basic 1-butyl-3-methylimidazolium ionic liquids attract more than stoichiometric quantities of water when exposed to air, suggesting that ionic liquid pretreatment under anhydrous conditions is difficult to achieve. Dissolution of air-dried wood chips in 1-butyl-3-methylimidazolium ionic liquids was attempted. It was shown that the large particle size and the moisture contained in the biomass hamper complete dissolution. The hydrogen-bond basicity of the ionic liquid, described by the Kamlet-Taft parameter ß, was correlated with the ability to expand as well as partially and anisotropically dissolve wood chips. Pretreatment of lignocellulosic biomass with 1-butyl-3- methylimidazolium methyl sulfate, 1-butyl-3-methylimidazolium hydrogen sulfate and 1-butyl-3-methylimidazolium methanesulfonate was explored and high saccharification yields were reported. It was found that successful application of methyl sulfate and hydrogen sulfate ionic liquids requires addition of water and that comparatively high water contents are tolerated. Fractionation of lignocellulose into an insoluble cellulose fraction, a solubilised hemicellulose fraction and a lignin containing precipitate was achieved. The influence of water content, pretreatment time and biomass type on the enzymatic saccharification yield and the extent of hemicellulose solubilisation, hydrolysis and dehydration were examined.
these licence 2021 (1).pdf
Creators: name: Djaafeur Djebbar, Riyadh
Publisher: name: figshare
Year: 2021
Subjects: subject: 90604 Microelectronics and Integrated Circuits
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90603 Industrial Electronics
subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: 20404 Electronic and Magnetic Properties of Condensed Matter; Superconductivity
subject: FOS: Physical sciences
subject: 190203 Electronic Media Art
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 40401 Electrical and Electromagnetic Methods in Geophysics
subject: FOS: Earth and related environmental sciences

description: Oscillateur contrôlé en tension (VCO), d'après le nom lui-même, il est clair que la fréquence du courant instantané de l'oscillateur est contrôlée par la tension d'entrée. C'est un type d'oscillateur qui peut produire une fréquence de signal de sortie sur une large plage (quelques hertz - centaines de gigahertz) en fonction de la tension continue qui lui est donnée.
Interactions of Natural Killer Cells, Dendritic Cells and Chemokines in Mycobacterium bovis Infection
Creators: name: Siddiqui, Nazneen
Publisher: name: Imperial College London
Year: 2011

description: Bovine Tuberculosis (TB), caused by Mycobacterium bovis (M.bovis), has seen a significant rise in incidence in recent years, posing a considerable burden to the UK economy. Protective immunity is associated in part, with rapid IFNγ production and early Th1 polarisation. Natural Killer (NK) cells are known to be a significant source of IFNγ and may therefore play a pivotal role in the innate immune response to mycobacterial infection. This study hypothesised that bovine NK cells participate in the immune response to bovine TB by migrating towards and reciprocally interacting with M.bovis infected dendritic cells (DCs). Bovine NK cells comprise a heterogeneous population characterised by the expression of NKp46 and CD2. Quantitative PCR analyses revealed that blood derived NKp46+ CD2- NK cells transcribed higher levels of important inflammatory and lymphoid homing chemokine receptors and preferentially migrated towards M.bovis infected DCs within in vitro chemotaxis assays when compared with NKp46+ CD2+ NK cells. Furthermore, within co-culture assays, M.bovis infected DCs selectively induced the release of IFNγ from NKp46+ CD2- NK cells with no detectable levels of IFNγ produced by NKp46+ CD2+ cells. This was partially reliant upon IL-12 secreted by M.bovis infected DCs as well as direct cell-cell contact. In addition, NKp46+ CD2- NK cells were able to reciprocally activate infected DCs resulting in up-regulation of cell surface MHC class II. Furthermore, IFNγ expressing NKp46+ CD2- NK cells were detected in the peripheral circulation of cattle as early as two days following experimental infection with M.bovis. This study has provided evidence of reciprocal interactions between CD2- NK cells and mycobacterially infected DCs that could augment both antigen presentation and Th1 biased immune responses. Therefore, this minor blood derived CD2- NK cell subset may be selectively responsible for promoting a protective immune response during the early phases of M.bovis infection and represents a potential target for future vaccination strategies.
Precision analysis for hardware acceleration of numerical algorithms
Creators: name: Boland, David Peter
Publisher: name: Imperial College London
Year: 2011

description: The precision used in an algorithm affects the error and performance of individual computations, the memory usage, and the potential parallelism for a fixed hardware budget. However, when migrating an algorithm onto hardware, the potential improvements that can be obtained by tuning the precision throughout an algorithm to meet a range or error specification are often overlooked; the major reason is that it is hard to choose a number system which can guarantee any such specification can be met. Instead, the problem is mitigated by opting to use IEEE standard double precision arithmetic so as to be ‘no worse’ than a software implementation. However, the flexibility in the number representation is one of the key factors that can be exploited on reconfigurable hardware such as FPGAs, and hence ignoring this potential significantly limits the performance achievable. In order to optimise the performance of hardware reliably, we require a method that can tractably calculate tight bounds for the error or range of any variable within an algorithm, but currently only a handful of methods to calculate such bounds exist, and these either sacrifice tightness or tractability, whilst simulation-based methods cannot guarantee the given error estimate. This thesis presents a new method to calculate these bounds, taking into account both input ranges and finite precision effects, which we show to be, in general, tighter in comparison to existing methods; this in turn can be used to tune the hardware to the algorithm specifications. We demonstrate the use of this software to optimise hardware for various algorithms to accelerate the solution of a system of linear equations, which forms the basis of many problems in engineering and science, and show that significant performance gains can be obtained by using this new approach in conjunction with more traditional hardware optimisations.
Phalaena chrysitis Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Phalaena
Phalaena chrysitis

description: Phalaena chrysitis [spec. nov.]
P. Noctua spirilinguis cristata, alis deflexis: superioribus orichalceis fascia grisea. Fn. svec. 875.
Alb. ins. t. 71.
Habitat in Galeopside, Mentha.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 513, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Conversion of Dioscorea zingiberensis saponins to prosapogenin A by enzymatic hydrolysis
Creators: name: Yang, Chengyu
name: Li, Bo
name: Zhou, Jinwei
name: Chen, Yufei
name: Xia, Guohua
name: Shen, Yuping
name: Chen, Jixuan
name: Shao, Jiali
name: Yang, Yaya
name: Yang, Huan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Prosapogenin A is a secondary saponin in Dioscorea zingiberensis, and it showed remarkable pharmacological effects. Due to very low content and lack of well-developed biotransformation, its preparation was not efficient and clean. This study aims to establish an eco-friendly strategy for preparation of Prosapogenin A from plant material. Physical separation was employed to recycle starch and cellulose, and then D101 resin and polyamide packed-bed column was incorporated for purification of total steroidal saponins (TSS). After these pretreatments, purity of TSS was largely increased to 83.2% with recovery at 87.6%, which was subjected to enzymatic hydrolysis. Optimized reaction system was constructed in 0.20 M HAc-NaAc buffer (pH4.2) containing cellulase/TSS (3:1, w/w), and the hydrolysis was performed at 53 °C for 6 h. Consequently, TSS was almost completely hydrolyzed to Prosapogenin A, while the highest yield reached 5.62%. The newly proposed approach is promising for efficient preparation of Prosapogenin A in industrial applications.
The radio properties of radio-quiet quasars
Creators: name: Kukula, M. J.
name: Dunlop, J. S.
name: Hughes, D. H.
name: Rawlings, S.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Although radio-quiet quasars (RQQs) constitute >90% of optically-identified quasar samples their radio properties are only poorly understood. In this paper we present the results of a multi-frequency VLA study of 27 low-redshift RQQs. We detect radio emission from 20 objects, half of which are unresolved (< 0.24''). In cases where significant structure can be resolved, double, triple and linear radio sources on scales of a few kpc are found. The radio emission (typically) has a steep spectrum (alpha ~ 0.7), and high brightness temperatures (T_B > 10^5 K) are measured in some of the radio components. The RQQs form a natural extension to the radio luminosity - absolute magnitude distribution of nearby Seyfert 1s. We conclude that a significant fraction of the radio emission in RQQs originates in a compact nuclear source directly associated with the quasar. There are no significant differences between the radio properties of RQQs with elliptical hosts and those in disc galaxies within the current sample.
description: 18 pages, 11 postscript figures, uses MN LaTeX style file v1.4, to appear in MNRAS
Fuzzy Cosets and their Gravity Duals
Creators: name: Trivedi, Sandip P.
name: Vaidya, Sachindeo
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Dp-branes placed in a certain external RR (p+4)-form field expand into a transverse fuzzy two-sphere, as shown by Myers. We find that by changing the (p+4)-form background other fuzzy cosets can be obtained. Three new examples, S^2 X S^2, CP^2 and SU(3)/(U(1) X U(1)) are constructed. The first two are four-dimensional while the last is six-dimensional. The dipole and quadrupole moments which result in these configurations are discussed. Finally, the gravity backgrounds dual to these vacua are examined in a leading order approximation. These are multi-centered solutions containing (p+4)- or (p+6)-dimensional brane singularities.
description: 36 pages, harvmac, no figures, two references added
Additional file 1: of Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages
Creators: name: G. Melendez-Torres
name: Armoiry, Xavier
name: Court, Rachel
name: Patterson, Jacoby
name: Kan, Alan
name: Auguste, Peter
name: Madan, Jason
name: Counsell, Carl
name: Ciccarelli, Olga
name: Clarke, Aileen
Publisher: name: figshare
Year: 2018
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Detailed search and data preparation methods. This file includes search strings, grey literature search sources, a sample data extraction form, and additional details on the statistical procedures undertaken to prepare study data for meta-analysis. (DOCX 47 kb)
Extragalactic Proper Motions: Gravitational Waves and Cosmology
Creators: name: Darling, Jeremy
name: Truebenbach, Alexandra
name: Paine, Jennie
Publisher: name: Maryland Shared Open Access Repository
Year: 2018

description: Extragalactic proper motions can reveal a variety of cosmological and local phenomena over a range of angular scales. These include observer-induced proper motions, such as the secular aberration drift caused by the solar acceleration about the Galactic Center and a secular extragalactic parallax resulting from our motion with respect to the cosmic microwave background rest frame. Cosmological effects include anisotropic expansion, transverse peculiar velocities induced by large scale structure, and the real-time evolution of the baryon acoustic oscillation. Long-period gravitational waves can deflect light rays, producing an apparent quadrupolar proper motion signal. We review these effects, their imprints on global correlated extragalactic proper motions, their expected amplitudes, the current best measurements (if any), and predictions for Gaia. Finally, we describe a possible long-baseline ngVLA program to measure or constrain these proper motion signals. In most cases, the ngVLA can surpass or complement the expected end-of-mission performance of the Gaia mission.
Secreted Proteins, Infectivity and Immunity to the Parasitic Nematode Nippostrongylus brasiliensis
Creators: name: Chan, Tsz Yau
Publisher: name: Imperial College London
Year: 2011

description: Comparative analysis of a recent isolate (J) and a laboratory-adapted strain (W) of the parasitic nematode Nippostrongylus brasiliensis found that the former had higher fecundity and gave rise to more persistent infections, although these traits were partially abolished after three years of laboratory passage, suggesting that infection dynamics can be modified by continuous high-dose propagation. Host immune responses to the two strains were similar in mode and magnitude. Proteins secreted by infective larvae (L3) and adult parasites showed some subtle differences between strains, although the activity of enzymes which might impact on persistence such as acetylcholinesterases and nucleotide metabolising enzymes were similar. Activation of N. brasiliensis L3 was not influenced by host serum, but a 37°C temperature cue was sufficient to induce feeding and protein secretion. Rat skin extracts induced chemotaxis of L3 and also induced the secretion of pre-synthesised proteins, although feeding and subsequent protein secretion were unaffected. Analysis of L3 secreted products by two-dimensional immunoblotting revealed differential immune recognition of specific proteins. Analysis of host resistin-like molecules showed that they had no effect on parasite chemotaxis and feeding activities, in contrast to published data. The venom-allergen homologue/ASP-like (VAL) proteins are important therapeutic targets found in all parasitic nematodes studied to date, and eight secreted variants of VALs have been discovered in N. brasiliensis. Although N. brasiliensis VALs (NbVALs) were found to be immunogenic during natural infection, immunisation with recombinant NbVAL-7 did not protect mice against challenge. Moreover, natural infection induced antigen-specific IgE and Type I hypersensitivity reactions to NbVALs, suggesting that this may be an intrinsic property of these proteins which limits their use in immunoprophylaxis of nematode infection.
Unconfirmed Near-Earth Objects
Creators: name: Vereš, Peter
name: Payne, Matthew J.
name: Holman, Matthew J.
name: Farnocchia, Davide
name: Williams, Gareth V.
name: Keys, Sonia
name: Boardman, Ian
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We studied the Near-Earth Asteroid (NEA) candidates posted on the Minor Planet Center's Near-Earth Object Confirmation Page (NEOCP) between years 2013 and 2016. Out of more than 17,000 NEA candidates, while the majority became either new discoveries or were associated with previously known objects, about 11% were unable to be followed-up or confirmed. We further demonstrate that of the unconfirmed candidates, 926+/-50 are likely to be NEAs, representing 18% of discovered NEAs in that period. Only 11% (~93) of the unconfirmed NEA candidates were large (having absolute magnitude H<22). To identify the reasons why these NEAs were not recovered, we analyzed those from the most prolific asteroid surveys: Pan-STARRS, the Catalina Sky Survey, the Dark Energy Survey, and the Space Surveillance Telescope. We examined the influence of plane-of-sky positions and rates of motion, brightnesses, submission delays, and computed absolute magnitudes, as well as correlations with the phase of the moon and seasonal effects. We find that delayed submission of newly discovered NEA candidate to the NEOCP drove a large fraction of the unconfirmed NEA candidates. A high rate of motion was another significant contributing factor. We suggest that prompt submission of suspected NEA discoveries and rapid response to fast moving targets and targets with fast growing ephemeris uncertainty would allow better coordination among dedicated follow-up observers, decrease the number of unconfirmed NEA candidates, and increase the discovery rate of NEAs.
description: 35 pages, 19 figures, 8 tables
Secular Extragalactic Parallax: Measurement Methods and Predictions for Gaia
Creators: name: Paine, Jennie
name: Darling, Jeremy
name: Graziani, Romain
name: Courtois, Hèléne M.
Publisher: name: AAS
Year: 2020

description: Secular extragalactic parallax caused by the solar system's velocity relative to the cosmic microwave background rest frame may be observable as a dipole proper motion field with amplitude 78 μas yr⁻¹ Mpc. Nearby galaxies also exhibit proper motions caused by their transverse peculiar velocities that prevent detection of secular parallax for any single galaxy, although a statistical detection may be made instead. Such a detection could constrain the local Hubble parameter. We present methods to measure secular parallax using correlated extragalactic proper motions and find a first limit on the secular parallax amplitude using proper motions of 232 nearby galaxies from Gaia Data Release 2. The recovered dipole has an insignificant upper limit of 3500 μas yr⁻¹ Mpc. This measurement will be improved by a larger sample size and reduced proper motion uncertainties in future data releases. Using the local peculiar velocity field derived from Cosmicflows-3, we simulate galaxy proper motions and predict that a significant detection (5–10σ) of the secular parallax amplitude will be possible by Gaia's end of mission. The detection does not correspond to a constraint on the Hubble parameter because it depends on nearby (<5 Mpc), bright (G < 15 mag) galaxies and the underlying peculiar motion dipole. We further investigate the implications of our simulations for the study of transverse peculiar velocities. The peculiar velocity field additionally results in low multipole-correlated proper motions on the order of 0.3 μas yr⁻¹ that may be confounded with other cosmological proper motion measurements, such as limits on the gravitational-wave background and the anisotropy of the Hubble expansion.
A Cytomorphometric Analysis of Oral Mucosal Changes in Tobacco Users
Creators: name: Mathew, Anju
Publisher: name: Zenodo
Year: 2021
Subjects: Cytomorphometry
exfoliative cytology
cellular diameter
nuclear diameter
nuclear cytoplasmic ratio

description: Aim: To investigate the effect of tobacco smoking and chewing on the buccal mucosa using cytomorphometry. Materials and Methodology: Oral mucosal cells were collected from 45 subjects divided into three groups: smokers, chewers, and nonsmokers.The cells were stained with Papanicolaou stain and examined under a high magnification microscope. Image J analysis software was used to perform cytomorphometric analyses on the cells in the captured image to determine the Cellular Diameter, Nuclear Diameter, and Nuclear Cytoplasmic Ratio. The statistical test used was ANOVA and p<0.05 was considered significant. Results: From controls to smokers and chewers, cellular diameter decreases while nuclear diameter and nuclear cytoplasmic ratio increase. Conclusion: The findings indicated that chewing tobacco changed the cytomorphology of normal buccal mucosa, and that the degree of change was greater in chewers than in smokers.Oral smears can be analysed cytomorphometrically on a regular basis to detect changes in cellular and nuclear dimensions, particularly among tobacco users.
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00377
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00377, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Phalaena interrogationis Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Phalaena
Phalaena interrogationis

description: Phalaena interrogationis [spec. nov.]
P. Noctua spirilinguis cristata, alis deflexis: superioribus cinereis signo? albo inscriptis.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 513, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
3D Kinematics of Stellar SiO Masers in the Galactic Center
Creators: name: Paine, Jennie
name: Darling, Jeremy
Publisher: name: AAS
Year: 2022

description: We present 3D velocity measurements and acceleration limits for stars within a few parsec of the Galactic Center (GC) black hole, Sgr A*, based on observations of 43 and 86 GHz circumstellar maser emission. Observations were taken with the Very Large Array in 2013, 2014, and 2020 and with the Atacama Large Millimeter/submillimeter Array in 2015 and 2017. We detect 28 masers in total, of which four are new detections. Combining these data with extant maser astrometry, we calculate stellar proper motions and accelerations with uncertainties as low as ∼10 μas yr⁻¹ and 0.5 μas yr⁻², respectively, corresponding to approximately 0.5 km s⁻¹ and 0.04 km s⁻¹ yr⁻¹ at a distance of 8 kpc. We measure radial velocities from maser spectra with ∼0.5 km s⁻¹ uncertainties, though the precision and accuracy of such measurements for deducing the underlying stellar velocities are limited by the complex spectral profiles of some masers. We therefore measure radial acceleration limits with typical uncertainties of ∼0.1 km s⁻¹ yr⁻¹. We analyze the resulting 3D velocities and accelerations with respect to expected motions resulting from models of the mass distribution in the GC.
Regulation of lymphocyte trafficking to the human gut in physiology and disease
Creators: name: Wang, Amu
Publisher: name: Imperial College London
Year: 2011

description: Memory T cell recruitment to the non-lymphoid tissue of the intestine (the gut lamina propria) requires the interactions between integrin a4B7 and its ligand Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1), which is exclusively expressed in the gut microvasculature. T cell homing to small intestine also requires the expression of chemokine receptor CCR9 on T cells, whose ligand - the gut chemokine CCL25 - is abundantly expressed in the small intestine. The a4B7 integrin and chemokine receptor CCR9 are known as the "homing" molecules whose expression is "imprinted" on T cells by intestinal dendritic cells during antigen presentation. In the first part of this thesis, data from in vitro studies showed that other than retinoic acid, soluble tissue-derived factors such as the gut chemokine CCL25 and T cell growth factor IL-2 also contributed to the induction of gut-homing receptor acquisition. Moreover, the expression of a4B7 integrin and CCR9 appeared to be modulated differently. The present study suggests that under the influence of tissue-derived factors, T cell acquisition of a4B7 integrin is the "default" response at steady state, and that only fully activated T cells are able to express high levels of CCR9. In the second part of this thesis, T cell gut homing was investigated in the context of disease, i.e. inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). IBD is characterized by excessive lymphocyte infiltration to the intestine. By quantitatively analyzing peripheral blood and intestinal lymphocyte subsets, proportional changes in the circulating gut-homing T cells (a4B7+) was found to be associated with CD. In addition, my data suggest that downregulation of T cell receptor zeta chain (TcRC) correlates to disease severity in both CD and UC. Measuring TcRC expression may thus provide an additional tool for the monitoring and management of IBD.
An Extended N=1 Fermionic Supercurrent and its Associated N=2 Superconformal Algebra
Creators: name: Pierce, David M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: An extended free fermionic construction of the internal N=1 world sheet supercurrent for four-dimensional superstring theory is given. We show how it can describe theories with massless fermions, and we discuss the corresponding N=2 superconformal algebra. As an intermediate step, we show that an internal N=2 global superconformal invariance occurs in any superstring theory with massless fermions at tree level. To demonstrate this fact, we give the N=2 supercurrents for a model with N=1 space-time supersymmetry and a model without space-time supersymmetry.
description: 10 pages
Topoisomerases inhibitory activities and DNA binding properties of 9-methoxycamptothecin from Nothapodytes nimmoniana (J. Graham) Mabberly
Creators: name: Wang, Haiyan
name: Ao, Mingzhang
name: Liu, Weitu
name: Bai, Yun
name: Zhu, Yuanmin
name: Yu, Longjiang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: We have reported previously that 9-methoxycamptothecin (MCPT) showed significant antitumor activity in vitro. Here, agarose gel electrophoresis experiments were performed to evaluate MCPT’s unwinding ability toward plasmid DNA and inhibitory activities against topoisomerases (Topo) I and II. Binding properties of MCPT to calf thymus DNA (CT-DNA) were evaluated by UV–vis, melting temperature, fluorescence, circular dichroism methodologies and molecular docking technique. Results showed that MCPT at 100 μM inhibited Topo I activity, but had no effect on Topo II. Studies on the binding properties indicated that minor groove binding was the most probable binding mode of MCPT to DNA. The abilities of MCPT to act as Topo I inhibitor and minor groove binding agent may be related to its strong antitumor activity.
Wilson loops in 5d $\mathcal{N}=1$ theories and S-duality
Creators: name: Assel, Benjamin
name: Sciarappa, Antonio
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the action of S-duality on half-BPS Wilson loop operators in 5d $\mathcal{N}=1$ theories. The duality is the statement that different massive deformations of a single 5d SCFT are described by different gauge theories, or equivalently that the SCFT points in parameter space of two gauge theories coincide. The pairs of dual theories that we study are realized by brane webs in type IIB string theory that are S-dual to each other. We focus on $SU(2)$ SQCD theories with $N_f \le 4$ flavors, which are self-dual, and on $SU(3)$ SQCD theories, which are dual to $SU(2)^2$ quiver theories. From string theory engineering we predict that Wilson loops are mapped to dual Wilson loops under S-duality. We confirm the predictions with exact computations of Wilson loop VEVs, which we extract from the 5d half-index in the presence of auxiliary loop operators (also known as higher qq-characters) sourced by D3 branes placed in the brane webs. A special role is played by Wilson loops in tensor products of the (anti)fundamental representation, which provide a natural basis to express the S-duality action. The exact computations also reveal the presence of additional multiplicative factors in the duality map, in the form of background Wilson loops.
description: 43+14 pages, 16 figures
title: Bioelectrical impedance analysis  of body composition Applications in sports science
Creators: name: Marini, Elisabetta
name: Toselli, Stefania
Publisher: name: UNICApress
Year: 2021

description: This book represents the result of an interdisciplinary and international effort to provide an updated overview of the theoretical and methodological principles of bioimpedance, and their applications in sports science.
The structure and the writing style are intended to be useful for scholars and students in a range of academic disciplines, as well as for professionals wishing to expand and consolidate their knowledge in the field.

The first chapter, entitled “Body composition”, describes the variability of body composition in the two sexes, during the life cycle, and in different populations, considering the relationship to life style and health status. It also summarises the relevant models for the analysis of body composition.
The second chapter “Bioelectrical impedance analysis: principles, instruments, and measurement methods” is centred on bioimpedance - the theoretical principles, the advantages and limitations, the measurements and analytical procedures -, illustrating both the conventional procedure based on predictive equations and the alternative ones, such as phase angle and bioelectrical impedance vector analysis (BIVA).
The third chapter “Bioelectrical impedance analysis: Research on body composition in sport science ” discusses the more recent applications of bioimpedance, and of BIVA in particular, in the field of physical training and sport.
Debt Management of Non-Financial Corporations
Creators: name: Laffont, Amandine Claire-Marie
Publisher: name: Imperial College London
Year: 2011

description: Debt management is of high importance for financial professionals and is a complex managerial decision, since the uncertainty of business cashflows may undermine the availability of financing, stress business operations and diminish future growth prospects. Whilst the management of corporate debt has sparked much interest and been widely discussed in the academic literature, none of the existing theories address this problem comprehensively. This thesis considers debt management decisions in non- financial corporations; it tests empirically various existing theories, establishes several stylised facts regarding funding decisions and contributes to the current research by exploring the influence of industry specific factors, financial intermediates and market conditions on debt management. Using U.S. data at the company level, the first study explores the variation of debt maturity across industry. Also, using both European bond and loan aggregate data, the second and third studies are the first ones, which highlight the impact of financial intermediates on both debt issuance and debt maturity timing strategies. The present work therefore offers both a cross-sectional overview of debt management and an analysis of its dynamics over time. The results indicate that (i) in addition to firm's characteristics, the cross-sectional variation of debt maturity can be explained by industry specific factors, which are not captured in the existing literature, (ii) that the agency cost hypothesis appears to be irrelevant for large cap firms, therefore giving more weight to the maturity-matching principle and the signaling hypothesis in explaining debt maturity structure, (iii) that managers tend to time their credit borrowing spread when they issue bonds and switch to the loan market during high interest rate periods, therefore contradicting earlier claims that interest rate timing explains time-series variations of debt issuance and (iv) that while corporates debt maturity mirror government debt maturity when directly placed debt is considered, financial intermediates act as a barrier to corporate debt maturity timing strategy.
The calculation of optical absorption spectra using linear-scaling density-functional theory
Creators: name: Ratcliff, Laura Elizabeth
Publisher: name: Imperial College London
Year: 2011

description: The goal of the work presented in this thesis was to develop and implement a method for calculating optical absorption spectra for large electronic systems within a linear-scaling density-functional theory (LS-DFT) formalism. The key feature of this method was the development of a scheme for optimizing a set of localized orbitals to accurately represent unoccupied Kohn-Sham states, which are not well represented by the localized orbital basis sets used for ground state LS-DFT calculations. Three different schemes were compared for the calculation of unoccupied states using a one-dimensional “toy model” and the most promising of these, based on the use of a projection operator, was implemented in a fully-functional LS-DFT code. Using the toy model, two methods for the calculation of band structures within a localized basis set were investigated and some of the features required by localized basis sets in order to produce accurate band structures were identified. The method was tested by the application to both molecular and extended systems, with calculations of densities of states, band structures and optical absorption spectra. The results for the smaller systems were validated by comparison with a cubic-scaling plane-wave density-functional theory code, with which excellent agreement was achieved. Additionally, the method was shown to be linear-scaling for a conjugated polymer for system sizes up to 1000 atoms. The use of the projection method was shown to be crucial for calculating the above results, as was the implementation of a momentum operator based formalism for the calculation of spectra. Finally, it was shown that the method can be used to identify the transitions responsible for particular peaks in the spectra and is sensitive enough to distinguish between spectra for systems with very similar structures, demonstrating the capabilities of the method to aid the interpretation of experimental results.
OPERAS, l'infrastruttura di ricerca nelle scienze umane e sociali / Università di Macerata
Creators: name: Giglia, Elena
Publisher: name: Zenodo
Year: 2024
Subjects: Open Science
OPERAS
SSH

description: Presentazione dell'infrastruttura OPERAS / Università di Macerata, 20 febbraio 2024

1) OPERAS, la visione e la missione

2) OPERAS nel panorame europeo

3) Un po' di storia e progetti in corso

4) Focus su Diamond e citizen science
Developing a gene targeting technology for Anopheles gambiae mosquitoes
Creators: name: Naujoks, Daniel
Publisher: name: Imperial College London
Year: 2012

description: Studying gene function in the human malaria vector Anopheles gambiae is the key to understanding its biology and vector-parasite interactions. Existing tools to study gene function do not include gene targeting, which would allow insights into gene function by permitting a range of specific modifications to any gene of choice. Based on developments in Drosophila (RONG and GOLIC 2000) this PhD project proposes to establish a method for gene targeting in Anopheles by homologous recombination, using a linear targeting construct generated in vivo. To this end, a transgenic strain was generated that expresses FLP recombinase and I-SceI endonuclease under the control of the germline-specific vasa promoter. Together they were to excise and linearise a targeting molecule from a transgenic “donor” locus. Homology in the targeting construct would enable integration, via recombination in the germline, at a gene of interest, thereby permitting its targeted modification. Expression of vasa-driven I-SceI resulted in high cleavage activity in the germline. A systematic analysis using a variety of transgenic target loci revealed that homologous repair, rather than non-homologous end joining, was the predominant mechanism employed to repair the double stranded breaks generated by I-SceI. These findings offer encouraging prospects for population genetic engineering using homing endonuclease genes (BURT 2003). FLP activity was shown in Anopheles cell culture, yet in vivo excision via FLP at two independent loci in the germline was not observed, precluding the obtainment of a knock-out. After eliminating many possible sources of error, likely causes include antagonistic interference between I-SceI and FLP or unfavourable reaction kinetics of FLP. Examination of the ortholog of Drosophila yellow-g1 as a target gene suggests it is required somatically for female fertility, making it a good candidate for vector population control with a genetic drive system based on homing endonuclease genes. Furthermore, the above finding that recombination is promoted by endonuclease activity driven by the vasa promoter augurs well for its use in mediating efficient drive in such a system.
Rapidity scan in heavy ion collisions at $\sqrt{s_{\rm NN}}=72$~GeV using a viscous hydro + cascade model
Creators: name: Karpenko, Iurii
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: In this note we discuss the rapidity dependence of the initial and final conditions for hydrodynamic evolution as well as the resulting basic hadronic observables in heavy ion collisions at $\sqrt{s_{\rm NN}}=72$ GeV in the framework of a viscous hydro+cascade model vHLLE+UrQMD. The resulting rapidity dependences are driven to a big extent by the initial state, which is simulated with the UrQMD cascade. The results can serve as a prediction for future experiments such as the AFTER@LHC or the BES-II program at STAR.
description: 8 pages, 6 figures