cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeted depletion of primary cilia in dopaminoceptive neurons in a preclinical mouse model of Huntington’s disease
Creators: name: Mustafa, Rasem
name: Kreiner, Grzegorz
name: Kamińska, Katarzyna
name: Wood, Amelia-Elise J.
name: Kirsch, Joachim
name: Tucker, Kerry
name: Parlato, Rosanna
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: primary cilium
subject: Huntington’s disease
subject: mTOR
subject: p62
subject: DDC 610 / Medicine & health
subject: Huntington disease
subject: Dopamine
subject: Receptors, Dopamine
subject: Cilia
subject: Huntington-Chorea
subject: Dopamin

description: Multiple pathomechanisms triggered by mutant Huntingtin (mHTT) underlie progressive degeneration of dopaminoceptive striatal neurons in Huntington’s disease (HD). The primary cilium is a membrane compartment that functions as a hub for various pathways that are dysregulated in HD, for example, dopamine (DA) receptor transmission and the mechanistic target of rapamycin (mTOR) pathway. The roles of primary cilia (PC) for the maintenance of striatal neurons and in HD progression remain unknown. Here, we investigated PC defects in vulnerable striatal neurons in a progressive model of HD, the mHTT-expressing knock-in zQ175 mice. We found that PC length is affected in striatal but not in cortical neurons, in association with the accumulation of mHTT. To explore the role of PC, we generated conditional mutant mice lacking IFT88, a component of the anterograde intraflagellar transport-B complex lacking PC in dopaminoceptive neurons. This mutation preserved the expression of the dopamine 1 receptor (D1R), and the survival of striatal neurons, but resulted in a mild increase of DA metabolites in the striatum, suggesting an imbalance of ciliary DA receptor transmission. Conditional loss of PC in zQ175 mice did not trigger astrogliosis, however, mTOR signaling was more active and resulted in a more pronounced accumulation of nuclear inclusions containing mHTT. Further studies will be required of aged mice to determine the role of aberrant ciliary function in more advanced stages of HD.
Evolution of the eukaryotic RNA polymerases
Creators: name: Carter, Robert
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.
subject: Biology, Evolution and Development.

description: All eukaryotes contain at least three homologous RNA polymerases (RNAPI, RNAPII, and RNAPIII), which are directed towards their target genes by interactions with RNAP-specific general transcription factors (GTFs). Although the RNAPs transcribe a subset of nuclear genes, it is unknown if they have evolved altered functionality. An in silico approach to identify putative differences in the three RNAPs was used to identify whether any functional differences likely exist by identifying amino acids that have experienced shifts in evolutionary rates and by identifying length differences between the cleft loops of the RNAPs. The difference in the levels of concerted evolution experienced by the genes transcribed by RNAPs was then exploited to test the molecular coevolution hypothesis of Dover and Flavell (1984. Cell . 38:622-623.). According to the molecular coevolution hypothesis, concertedly evolving DNA increases the evolutionary rate of any interacting proteins. We thus compared the evolutionary rates of the three RNAPs and their GTFs, since their target genes undergo different levels of concerted evolution. Finally, the origins of the 5 subunits that are specific to RNAPIII were examined, since no homologous relationships have been identified thus far for any of these subunits. Several sites that have experienced shifts in substitution rates in the ancestral RNAPs were found in all three enzymes and these sites were clustered near the active sites in all cases. Several cleft loops with different lengths (in amino acids) between the three RNAPs were also identified. The validity of the molecular coevolution hypothesis was largely confirmed via the demonstration that most subunits of RNAPI evolve faster than those of RNAPIII and most subunits of RNAPIII evolve faster than RNAPII. This is consistent with the molecular coevolution hypothesis because RNAPI experiences higher levels of concerted evolution than the target genes of RNAPIII. The evolutionary rates of the GTFs of RNAPI and RNAPIII were also higher than those of RNAPII. Finally, four of the five RNAPIII-specific subunits were identified as homologs of RNAPII GTFs, indicating that several of the GTF paralogs existed in ancestral RNAPIII and were subsequently recruited to the enzyme before the diversification of eukaryotes.
title: Raumforderungen i. R. einer IgG4-assoziierten Erkrankung(IgG4RD) bei vordiagnostizierter Granulomatose mit Polyangiitis (GPA)
Creators: name: Mohr, Ann-Christin
name: Gkanatsas, Yannik
name: Boro, Damir
name: Kötter, Ina
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Insgesamt stellten sich seit 10/2019 zwei Patientinnen mit einer vordiagnostizierten GPA und nun zusätzlicher Weichteil-Raumforderung (s. Tabelle 1 [img:Table 1]) vor. Leitsymptom bei Krankheitsmanifestation: Patientin A stellte sich mit einer schubweise auftretenden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
A retrospective sort of arrangement': Ulysses and the poetics of hypertextuality
Creators: name: Tofts, Darren
Publisher: name: Swinburne
Year: 2024

description: Hypertextuality is a term that we have come to associate with digital connectivity, hypertext and the computer revolution. It is also a term that has, in retrospect, be applied to James Joyce's Ulysses. Indeed, David Gold, in a detailed case study of the text, suggests that Ulysses is 'the perfect hypertext subject.'1 Such a view assumes some kind of correspondence between Ulysses and the emergent electronic architecture of hypertext, an acknowledgment that Ulysses is somehow like hypertext. On the basis of this homology, Ulysses is seen to be eminently eligible for hypertextualisation. However, the relationship between a literary work such as Ulysses and electronic hypertext is a problematic one. While the nomenclature of hypertext and hypertextuality dates back to the late 1960s, it was for many years unknown to literary criticism. Nevertheless, its association with literature as a form of poetics can be traced back to those formative years of hypertext research and development. Ted Nelson, author of Literary Machines and originator of the term hypertext, had clearly defined it in 1965 as a literary phenomenon. The importance for Ulysses scholarship of thinking of the literary in machinic terms, and the broader logic of hypertextual poetics, will hopefully become apparent in this paper.
Supplementary document for Scaling of metal-clad InP nanodisk lasers: optical performance and thermal effects - 4995245.pdf
Creators: name: Tiwari, Preksha
name: Wen, Pengyan
name: Caimi, Daniele
name: Mauthe, Svenja
name: Trivino, Noelia Vico
name: Sousa, Marilyne
name: Moselund, Kirsten
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Lasers and Quantum Electronics
Photonics, Optoelectronics and Optical Communications
Nanophotonics

description: Supplemental Document with Author List and without highlighted text.
Role of tactile noise in the control of digit normal force
Creators: name: Naceri, Abdeldjallil
name: Gultekin, Yasemin B.
name: Moscatelli, Alessandro
name: Ernst, Marc O.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Grasping
subject: Manipulation
subject: Tactile perturbation
subject: Normal force
subject: Tactile object
subject: DDC 150 / Psychology
subject: Motor ability
subject: Human mechanics
subject: Motorik
subject: Handgeschicklichkeit

description: Whenever we grasp and lift an object, our tactile system provides important information on the contact location and the force exerted on our skin. The human brain integrates signals from multiple sites for a coherent representation of object shape, inertia, weight, and other material properties. It is still an open question whether the control of grasp force occurs at the level of individual fingers or whether it is also influenced by the control and the signals from the other fingers of the same hand. In this work, we approached this question by asking participants to lift, transport, and replace a sensorized object, using three- and four-digit grasp. Tactile input was altered by covering participant's fingertips with a rubber thimble, which reduced the reliability of the tactile sensory input. In different experimental conditions, we covered between one and three fingers opposing the thumb. Normal forces at each finger and the thumb were recorded while grasping and holding the object, with and without the thimble. Consistently with previous studies, reducing tactile sensitivity increased the overall grasping force. The gasping force increased in the covered finger, whereas it did not change from baseline in the remaining bare fingers (except the thumb for equilibrium constraints). Digit placement and object tilt were not systematically affected by rubber thimble conditions. Our results suggest that, in each finger opposing thumb, digit normal force is controlled locally in response to the applied tactile perturbation.
La construction d'un problème social et sa mise en forme juridique: Le cas du harcèlement sexuel aux États-Unis
Creators: name: Lamb, Barbara
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Sociology, Criminology and Penology.

description: Dans cette étude, nous retraçons les activités de revendication - prenant place aux États-Unis, entre 1971 et 1981 - qui transformèrent le harcèlement sexuel d'une condition sans nom et sans problématisation, en un problème social faisant l'objet d'un contrôle normatif. Notre démarche s'appuie sur une analyse qualitative des discours revendicateurs, et fut encadrée par deux axes théoriques: (1) la sociologie des problèmes sociaux proposée par Spector et Kitsuse (1977/2001) nous guidera dans nos efforts de reconstituer "la carrière du harcèlement sexuel en tant que problème social", c'est-à-dire, sa transformation d'un problème individuel en un problème social; (2) certains éléments du modèle des illégalismes privilégiés d'Acosta (1988) seront utilisés comme balises à notre analyse de la mise en forme d'une réponse juridique dans un ou plusieurs cadres normatifs appelés à répondre aux demandes soulevées durant les activités de revendications. Nous retracerons l'histoire de la construction du problème social du harcèlement sexuel, à travers des activités de revendications ou participèrent entre autres: (1) des groupes d'intérêts féministes; (2) des plaignantes individuelles et leurs avocats; (3) des juges; (4) des juristes et chercheurs; et (5) le gouvernement fédéral américain. La chronologie de la construction du harcèlement sexuel en tant que problème social démontre que le problème fut créé et défini par tous ces acteurs sociaux qui intéragirent, s'affrontèrent, collaborèrent et négocièrent ensemble jusqu'à ce qu'une définition juridique soit entérinée: le harcèlement sexuel sera donc, en 1980, reconnu comme discrimination fondée sur le sexe en vertu du Title VII, par la proclamation des directives interprétatives sur le harcèlement sexuel émises par l'Equal Employment Opportunity Commission. Or, la prédominance d'une interprétation juridique n'est pas une garantie de son exclusivité: nous examinerons également les discours qui suggèrent la possibilité d'une appréhension des conflits en matière de harcèlement sexuel à partir d'autres cadres normatifs: le droit pénal, le common law, le droit du travail et les contrôles formels non étatiques. Si le harcèlement sexuel est certes primordialement soumis aux contrôles du droit antidiscriminatoire, il semble toutefois disposer d'un réseau de contrôle polysémique qui pourrait être appelé à répondre dans des cas concrets.
A comparative analysis of seismic retrofit techniques for reinforced concrete bridge columns
Creators: name: Sarrazin, Jacques
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Civil.

description: Reinforced concrete bridge columns built prior to 1971 cannot withstand earthquake forces due to insufficient transverse reinforcement, poor detailing, and lap-splices in the plastic hinge area. In order to correct this deficiency, these piers must be reinforced by confinement in the axis perpendicular to the longitudinal bars. Experimental research as well as field experience has shown that there are a significant number of technologies that are effective column retrofit solutions for the thousands of bridges worldwide that are in need of upgrade. There is a significant amount of documented research dealing with the technical effectiveness of individual techniques, however, very little research has compared these techniques for cast effectiveness and functionality. This dissertation addresses this issue by analyzing and conducting feasibility assessments of existing technologies, providing detailed retrofit designs for 6 circular and 6 square columns using four different approaches: steel jackets, FRP wrapping, concrete jackets and external pre-stressing and by pricing all of these designs. From this data, conclusions are drawn concerning the cost effectiveness of the four technologies. This study also analyses bridge assessment techniques.
title: Raynaud-Syndrom bei Hodentumor
Creators: name: Dittert, Philipp
name: Schneider, Udo
name: Biesen, Robert
name: Burmester, Gerd-Rüdiger
name: Krusche, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Anfang September 2019 hatte sich der bis dahin vollständig gesunde, 26-jährige Patient wegen einer schmerzhaften Schwellung des linken Skrotalfaches in der Urologie vorgestellt. Bei palpatorisch und sonografisch Malignom-verdächtigem linken Hoden und deutlich erhöhten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Performance evaluation of neural network-based short-term solar irradiation forecasts
Creators: name: Liebermann, Simon
name: Um, Jung-Sup
name: Hwang, YoungSeok
name: Schlüter, Stephan
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: neural network
subject: solar irradiation
subject: time series forecasting
subject: LSTM
subject: CNN
subject: C45
subject: C53
subject: C58
subject: DDC 000 / Computer science, information & general works
subject: Neural computers
subject: Neuronales Netz

description: Due to the globally increasing share of renewable energy sources like wind and solar power, precise forecasts for weather data are becoming more and more important. To compute such forecasts numerous authors apply neural networks (NN), whereby models became ever more complex recently. Using solar irradiation as an example, we verify if this additional complexity is required in terms of forecasting precision. Different NN models, namely the long-short term (LSTM) neural network, a convolutional neural network (CNN), and combinations of both are benchmarked against each other. The naive forecast is included as a baseline. Various locations across Europe are tested to analyze the models’ performance under different climate conditions. Forecasts up to 24 h in advance are generated and compared using different goodness of fit (GoF) measures. Besides, errors are analyzed in the time domain. As expected, the error of all models increases with rising forecasting horizon. Over all test stations it shows that combining an LSTM network with a CNN yields the best performance. However, regarding the chosen GoF measures, differences to the alternative approaches are fairly small. The hybrid model’s advantage lies not in the improved GoF but in its versatility: contrary to an LSTM or a CNN, it produces good results under all tested weather conditions.
What matters 2017 - Annual Report of the German Environment Agency
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2017
Subjects: subject: Umweltbundesamt
subject: What Matters
subject: agriculture
subject: climate
subject: indoor air quality
subject: Klima | Energie
subject: Luft
subject: Gesundheit
subject: Boden | Fläche

description: Environmental issues in the agricultural sector / Indoor air quality and health / What does the Paris Agreement mean for Germany? In our yearly publication we examine three environmental topics in depth from a scientific point of view. Additionally the publication explores UBA as a workplace and whether art can be used to shape environmental transition. Quelle: https://www.umweltbundesamt.de/
description: Environmental issues in the agricultural sector / Indoor air quality and health / What does the Paris Agreement mean for Germany?In our yearly publication we examine three environmental topics in depth from a scientific point of view. Additionally the publication explores ⁠UBA⁠ as a workplace and whether art can be used to shape environmental transition.
The use of ecologic covariates in cohort mortality studies: A re-analysis of the American Cancer Society study of the health effects of particulate air pollution.
Creators: name: Willis, Alette.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Public Health.

description: Background. Recent studies of long-term exposure to ambient air pollution suggest that particulate matter in urban air is a risk factor for mortality. However, these studies are potentially biased because they have not taken into account spatial processes. This thesis examines the effect of exposure to sulfate air pollution when place-specific covariates, scale and spatial autocorrelation are controlled for. Methods. This thesis builds upon the American Cancer Society (ACS) Study by introducing place-specific covariates into the original Cox models. In addition, a new two-stage analysis using both metropolitan and county scale covariates is employed in the analysis of the ACS data. Finally a method of filtering out spatial autocorrelation is applied to the data. Results. For all-cause mortality, the original ACS Study found a RR of 1.15 (95% confidence interval of 1.09, 1.22) from sulfates. This was reduced to 1.06 (0.99, 1.13) by the inclusion of the place-specific covariate population change. Using the two-stage method to allow for clustering within metropolitan areas, the RR from sulfates increased to 1.25 (1.13, 1.37). When regional trends were controlled for, the RR decreased to 1.19 (1.06, 1.34). When this metropolitan data was filtered to remove spatial autocorrelation, the RR decreased again to 1.09 (1.01, 1.19). However, when counties were used instead the RR increased to 1.50 (1.30, 1.73). Conclusions. Taking into account spatial processes affects the observed association between ambient sulfate air pollution and mortality. That the sulfate effect is larger and more robust to the inclusion of place-specific covariates at the county scale provides further evidence that ambient sulfate air pollution is a population health hazard.
Oltreoceano: rappresentazione e autorappresentazione nelle lettere degli emigranti scozzesi del 19° secolo
Creators: name: Dossena, Marina
Publisher: name: Iperstoria
Year: 2020

description: The study of (self-)representation in nineteenth-century Scottish emigrants’ letters presupposes the use of a range of sources which may prove very complex in their plurality. They are generally documents authored by people whose level of schooling could vary considerably and whose self-education may in fact be perceived in their letters, journals, memoirs and autobiographies. These materials may be supplemented with journal reports, literary travelogues, and emigrants’ guides which purport to describe what emigrants may expect to find upon arrival, but whose reliability is not always guaranteed. In addition, there may be other sources, mostly pertaining to music and painting, in which emigration is portrayed in apparently subjective terms, but which contribute to the creation and maintenance of a collective view of reality, whether veined with nostalgia for ‘the old country’ or enthusiastically encouraging settlement in new territories. In this paper such sources are discussed in order to highlight their main intertextual connections; more specifically, my analysis will focus on emigrants’ correspondence from North America, in an attempt to draw attention to the value of such materials in a study of ‘language history from below’.
description: Iperstoria, No 7 (2016): Old and New West
Dataverse North Metadata Best Practices Guide
Creators: name: Cooper, Alexandra
name: Gagnon, Martine
name: Leahey, Amber
name: Paquette-Bigras, Ève
name: Perrier, Laure
name: Steeleworthy, Michael
name: Taylor, Sally
Publisher: name: The University of British Columbia
Year: 2019

description: The first version of the guide provides users with best practices for creating citation metadata in Dataverse. The guide provides definitions of metadata fields and clarification where needed; distinguishes between required, recommended and optional fields; and illustrates the use of each field with an example. Future editions will provide guidance for disciplinary metadata blocks in Dataverse, namely, Social Sciences and Humanities, Geospatial, Life Sciences, and Astronomy & Astrophysics Metadata.
A complete and terminating execution model for Constraint Handling Rules
Creators: name: Raiser, Frank
name: Betz, Hariolf
name: Frühwirth, Thom
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: CHR
subject: Constraint Handling Rules
subject: DDC 004 / Data processing & computer science
subject: Constraint programming (Computer science)
subject: Declarative programming
subject: Logic programming
subject: Constraint-Programmierung

description: We observe that the various formulations of the operational semantics of Constraint Handling Rules proposed over the years fall into a spectrum ranging from the analytical to the pragmatic. While existing analytical formulations facilitate program analysis and formal proofs of program properties, they cannot be implemented as is. We propose a novel operational semantics, which has a strong analytical foundation, while featuring a terminating execution model. We prove its soundness and completeness with respect to existing analytical formulations and we compare its expressivity to that of various other formulations.
Esploratori, cacciatori e mercanti
Creators: name: Cartosio, Bruno
Publisher: name: Iperstoria
Year: 2020

description: La ‘conquista dell’Ovest’ da parte degli statunitensi ha inizio con la costituzione stessa della nuova nazione. E durante l’intero Ottocento, spesso camuffata sotto le spoglie dell’esplorazione geografica e della ricerca scientifica, la penetrazione delle terre sconosciute sarà finalizzata soprattutto a obiettivi di carattere economico: commerciale, agricolo, minerario, industriale. Dal punto di vista più strettamente istituzionale, nella prima parte del secolo, oltre alle popolazioni indiane, gli antagonisti sono gli imperi spagnolo e britannico; dopo la Guerra civile, saranno soltanto gli indiani.
description: Iperstoria, No 7 (2016): Old and New West
title: Halo-Zeichen bei P(an)-Vaskulitis?
Creators: name: Krusche, Martin
name: Schneider, Udo
name: Holl-Ulrich, Konstanze
name: Burmester, Gerd-Rüdiger
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Ein 60-jähriger Patient wurde im April 2019 mit Verdacht auf Vaskulitis in unsere Abteilung überwiesen. Der Patient berichtete über seit 9 Monate bestehende rezidivierende Cephalgien, Sehstörungen, Schwindel, sowie eine B-Symptomatik mit ungewolltem Gewichtsverlust[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Control of accommodation payments made by transnational corporations.
Creators: name: Jalan, Abhimanyu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Law.

description: This dissertation attempts to shed light on illegal and questionable payments made by the transnational corporations. It commences with a definition of the kinds of payments to be considered, discusses the various elements involved in the making of such payments, and identifies the various parties involved in such transactions. It then goes on to analyze the effects of such payments in detail, highlighting their economic and socio-political impact, in an effort to provide a justification for controlling such payments. Thereafter, the dissertation discusses the benefits of an international code as a means to control such payments and provides a detailed discussion of the international efforts made to date by various international organisations like the United Nations and the Organisation for Economic Cooperation and Development (OECD). The dissertation then outlines the problems which hamper the successful implementation of these international efforts. This section contains a discussion as to the impediment created by the conflicting stance taken by the developed and the developing countries on the matter. After taking all this into consideration, the dissertation focuses on the problems encountered by nations which unilaterally attempt to curb the practice of making illegal and questionable payments, and the experience of the United States of America is discussed in detail. Finally, the dissertation suggests means which might help in controlling and more effectively restraining the transnational corporations and all the parties involved from resorting to illegal or questionable payments in international commercial transactions in the near future.
Tuning p-wave interactions in an ultracold Fermi gas of atoms
Creators: name: Regal, Cindy A.
name: Ticknor, C.
name: Bohn, John L.
name: Jin, Deborah S.
Publisher: name: Swinburne
Year: 2024

description: We have measured a p-wave Feshbach resonance in a single-component, ultracold Fermi gas of K-40 atoms. We have used this resonance to enhance the normally suppressed p-wave collision cross section to values larger than the background s-wave cross section between K-40 atoms in different spin states. In addition to the modification of two-body elastic processes, the resonance dramatically enhances three-body inelastic collisional loss.
title: 30-jährige Patientin mit plötzlich aufgetretenen hämorrhagischen Nekrosen beider Beine
Creators: name: Graßhoff, Hanna
name: Janusch, Heike
name: Sailer, Verena-Wilbeth
name: Arnold, Sabrina
name: Humrich, Jens
name: Riemekasten, Gabriela
name: Lamprecht, Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Aufnahme einer 30-jährigen Patientin mit großflächigen, konfluierenden Ekchymosen beider Beine, die sich im Verlauf weniger Stunden ausgebildet hatten. Vier Jahre zuvor war ein systemischer Lupus erythematodes (SLE) mit Schmetterlingserythem, Coombs-Test positiver hämolytischer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Thermokarst sedimentology of the Tuktoyaktuk Coastlands, Northwest Territories.
Creators: name: Murton, Julian Baird.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Geology.

description: Thermokarst sedimentology is the study of the sedimentary processes and facies associated with thermokarst. Using facies analysis, oxygen isotopes and observations of processes in the Tuktoyaktuk Coastlands, this thesis (1) classifies frozen ground according to its cryostructures and cryofacies; (2) describes thermokarst facies, facies associations and sedimentary structures; (3) examines the sedimentary processes associated with thermokarst; (4) proposes thermokarst facies models; and (5) proposes criteria for identifying thermokarst-modified sediments. The thermokarst sedimentary system of the Tuktoyaktuk Coastlands comprises uplands, slopes and basins. Beneath ice-rich uplands, downwearing thermokarst produces a thick ($\le$c. 2.5m) thaw layer in which sediments melt-out from underlying permafrost. Ice-rich slopes are subdivided into steep icy slopes and retrogressive thaw slumps, the former occurring where the percentage of excess ice in upland materials is less than c. 30-40%, the latter where it exceeds this value. As slopes retreat by backwearing thermokarst, upland materials are redeposited by alluvial and colluvial processes. Thermokarst basins form where back- and downwearing thermokarst coincide. In deep non-oriented basins containing thermokarst lakes, three stages of basin infilling are identified. The first occurs during early and rapid basin expansion, when intense backwearing thermokarst at basin margins transports large quantities of upland materials into the basins. This pulse of resedimentation initiates sublacustrine benches. The second stage beings as the rate of basin expansion diminishes, reducing the influx of clastic sediment into lakes; thus the tops of sublacustrine benches are reworked and the main depositional process changes to suspension settling in basin centres. The final stage, commencing as lakes drain, involves basin infilling by peat accumulation and by gelifluction and aeolian deposition. Two sedimentary structures relating to thermokarst are frost-fissure pseudomorphs and thermokarst involutions. Frost-fissure pseudomorphs develop through thaw-modification processes: slow subsidence, thermal erosion, refreezing, loading, buoyancy, spreading, folding, shearing and mass movement. Thermokarst involutions form primarily by water-escape or by loading and buoyancy. Involutions within a thick palaeothaw layer probably reflect the massive scale of soft-sediment deformation that accompanies regional thermokarst, and they provide a potential analogue for some Pleistocene involutions in the mid-latitudes. Five criteria identify thermokarst-modified sediments in the Tuktoyaktuk Coastlands: (1) organic-rich (and sandy) diamicton; (2) granular mud aggregates in stratified facies; (3) impure sand ($\pm$diamicton); (4) frost-fissure pseudomorphs; and (5) thermokarst involutions.
title: Multisensibel und doch so tückisch
Creators: name: Huber, Melanie
name: Bress, Kirsten
name: Hunfeld, Klaus-Peter
name: Müller-Ladner, Ulf
name: Tarner, Ingo H.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Ein 52-jähriger Patient wurde aufgrund eines Overlap-Syndroms aus ANCA-negativer Kleingefäßvaskulitis (Colonbeteiligung, axonale Polyneuropathie) und RF-positiver rheumatoider Arthritis mit Rituximab und low-dose Prednisolon behandelt. Während einer Umstellung auf [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Photodynamic therapy combined with Bcl-2/Bcl-xL inhibition increases the Noxa/Mcl-1 ratio independent of usp9X and synergistically enhances apoptosis in glioblastoma
Creators: name: Golla, Carolin
name: Bilal, Mayas
name: Dwucet, Annika
name: Bader, Nicolas
name: Anthonymuthu, Jenson
name: Heiland, Tim
name: Pruss, Maximilian
name: Westhoff, Mike-Andrew
name: Siegelin, Markus David
name: Capanni, Felix
name: Wirtz, Christian Rainer
name: Kast, Richard Eric
name: Halatsch, Marc-Eric
name: Karpel-Massler, Georg
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: 5-aminolevulinic acid
subject: photodynamic therapy
subject: ABT-263
subject: navitoclax
subject: Bcl-xL
subject: NAVITOCLAX ABT-263
subject: RAC1
subject: Glioma-cells
subject: DDC 610 / Medicine & health
subject: Glioblastoma; Drug therapy
subject: Pharmacokinetics
subject: Temozolomide
subject: Proto-oncogene proteins c-bcl-2
subject: Photochemotherapy
subject: Glioma
subject: Glioblastom
subject: Pharmakotherapie
subject: Fotodynamische Therapie
subject: BAG-Proteinfamilie

description: The purpose of this study was to assess in vitro whether the biological effects of 5-aminolevulinic acid (5-ALA)-based photodynamic therapy are enhanced by inhibition of the anti-apoptotic Bcl-2 family proteins Bcl-2 and Bcl-xL in different glioblastoma models. Pre-clinical testing of a microcontroller-based device emitting light of 405 nm wavelength in combination with exposure to 5-ALA (PDT) and the Bcl-2/Bcl-xL inhibitor ABT-263 (navitoclax) was performed in human established and primary cultured glioblastoma cells as well as glioma stem-like cells. We applied cell count analyses to assess cellular proliferation and Annexin V/PI staining to examine pro-apoptotic effects. Western blot analyses and specific knockdown experiments using siRNA were used to examine molecular mechanisms of action. Bcl-2/Bcl-xL inhibition synergistically enhanced apoptosis in combination with PDT. This effect was caspase-dependent. On the molecular level, PDT caused an increased Noxa/Mcl-1 ratio, which was even more pronounced when combined with ABT-263 in a Usp9X-independent manner. Our data showed that Bcl-2/Bcl-xL inhibition increases the response of glioblastoma cells toward photodynamic therapy. This effect can be partly attributed to cytotoxicity and is likely related to a pro-apoptotic shift because of an increased Noxa/Mcl-1 ratio. The results of this study warrant further investigation.
Supplementary document for Scaling of metal-clad InP nanodisk lasers: optical performance and thermal effects - 4995245.pdf
Creators: name: Tiwari, Preksha
name: Wen, Pengyan
name: Caimi, Daniele
name: Mauthe, Svenja
name: Trivino, Noelia Vico
name: Sousa, Marilyne
name: Moselund, Kirsten
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Lasers and Quantum Electronics
Photonics, Optoelectronics and Optical Communications
Nanophotonics

description: Supplemental Document with Author List and without highlighted text.
title: Sicca-Symptomatik, Dysphonie und unklare Hautveränderungen – die Histologie ändert die Therapie
Creators: name: Gödecke, Vega
name: Schefzyk, Matthias
name: Spangenberg, Astrid
name: Bräsen, Jan Hinrich
name: Witte, Torsten
name: Kratz, Christian
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Die 63-jährige Patientin stellt sich in der Ambulanz des Zentrums für seltene Erkrankungen der Medizinischen Hochschule Hannover vor. Seit August 2018 besteht nach einer Kehlkopfentzündung eine progrediente Dysphonie und Dysphagie. Im Jahre 2017 ist eine Karpaltunnel-OP[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
A comparison of item parameter estimates and ICCs produced with TESTGRAF and BILOG under different test lengths and sample sizes.
Creators: name: Patsula, Liane.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Education, Tests and Measurements.

description: There are many procedures used to estimate IRT parameters; however, among the most popular techniques are those used in the LOGIST and BILOG computer programs. LOGIST requires large numbers of examinees and items (in the order of 1000 or more examinees and 40 or more items) for stable 3PL model parameter estimates. BILOG is a more recent estimation program and, in general, requires smaller numbers of examinees and items than LOGIST for stable 3PL model parameter estimates. It also has been found that, regardless of sample size and test length, BILOG estimates tend to be uniformly more or at least as accurate as LOGIST estimates. For this reason, BILOG is now used as the standard to which new estimation programs are compared. The purpose of this study was to examine the effects of varying sample size (N = 100, 250, 500, and 1000) and test length (20- and 40-item tests) on the accuracy and consistency of 3PL model item parameter estimates and ICCs obtained from TESTGRAF and BILOG. Overall, TESTGRAF seemed to perform better or just as well as BILOG. Where large bias effect sizes existed, in all but one case, TESTGRAF was more accurate than BILOG. TESTGRAF was slightly less accurate than BILOG in estimating the $P(\theta$)'s at high ability levels. Where large efficiency effect sizes existed, in all but two cases, TESTGRAF was more consistent than BILOG. TESTGRAF was slightly less consistent than BILOG in estimating the a parameter with a sample size of 1000 and in estimating the c parameter at all sample sizes. (Abstract shortened by UMI.)
Determinants of environmental disclosures in a developing country: an application of the stakeholder theory
Creators: name: Elijido-Ten, Evangeline
Publisher: name: Swinburne
Year: 2024

description: This study uses the stakeholder theory to uncover the determinants of environmental disclosures in Malaysian companies. The stakeholder theory is operationalised using Ullman’s (1985) three-dimensional framework that includes stakeholder power, strategic posture and economic performance. Given the current regulatory framework in Malaysia where no mandatory environmental reporting is required and where the companies’ environmental performance is kept confidential, the findings suggest that the main determinants in providing environmental disclosures is the level of environmental concern (EC) by the top management (a measure of strategic posture) and the government’s power (GP) to sanction companies (a measure of stakeholder power). Measures of economic performance showed no significant relation with the level of environmental disclosure. This study also found that the majority of environmental disclosures are still confined to the provision of general or vague descriptions. Hence, there is a lot of room for improvement as to the quality of disclosure.
title: Infektanfälligkeit und Asthma – zwei Seiten derselben Medaille?
Creators: name: Winau, Lea
name: Feist, Jonas
name: Skapenko, Alla
name: Schulze-Koops, Hendrik
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Eine 32-jährige Patientin stellte sich im März 2020 in unserer Ambulanz zur Abklärung einer vermehrten Infektanfälligkeit vor. Die Patientin sei bereits im Kindesalter häufig an Infekten der oberen Atemwege sowie seit dem 12. Lebensjahr an rezidivierende Zystitiden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Topochemical reactions of amines and amides with titanium and vanadium oxychlorides.
Creators: name: Kargina, Irina.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Chemistry, Inorganic.

description: The intercalation of primary, secondary, tertiary, and aromatic amines into layered TiOCl have been investigated by a variety of methods. The intercalation reaction does not appear to be a redox process. A key step for intercalation of amines into host TiOCl is proposed to be a coordination via nitrogen lone electron pair to Ti$\sp{3+}$ metal centres. Subsequent substitution of the interlayer chloride ions of TiOCl by the amine molecules is strongly dependent on the properties of the organic compounds and their ability to form ammonium salts. Based on X-ray diffraction, fluorescence, elemental analysis and thermal analysis, a model for the interaction of amines with TiOCl is proposed. The intercalation of primary, secondary, and tertiary amides into TiOCl and VOCl have been studied. A redox intercalation process is ruled out by using variety of amides with a range of redox potentials. The proposed interaction of intercalated amides with the host is different from that of amines and may dominated by formation of hydrogen bonds between the amides protons and Cl ions of the host.
Adaptive equalization of frequency selective indoor wireless channels.
Creators: name: Chen, Xuan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Engineering, Electronics and Electrical.

description: In this thesis, we examine the performance of adaptive linear, T/2 fractionally spaced, and decision feedback equalizers (LE, FSE and DFE) for digital communication systems over indoor wireless channels affected by frequency selective fading. The channel is modeled as both fixed and time varying channels, and the data transmission rate is 10 M bits/s. The simulation results show that, with differential encoding, the quadrature phase shift keying (DQPSK) modulation scheme outperforms 4-state and 8-state 8PSK-based trellis coded modulations (D8PTCM4 and D8PTCM8), when the DFE with the least-mean-square (LMS) algorithm (DFELMS) is used. While D8PTCM4 has better BER performance than D8PTCM8 with the DFELMS over time varying channels, the reverse conclusion can be obtained over fixed channels. When the recursive least-square (RLS) algorithm is applied instead of the LMS algorithm, the systems with the DFERLS can achieve slightly better bit error rate (BER) performance than those with the DFELMS.
Guide des pratiques exemplaires sur les métadonnées de Dataverse Nord
Creators: name: Cooper, Alexandra
name: Gagnon, Martine
name: Leahey, Amber
name: Paquette-Bigras, Ève
name: Perrier, Laure
name: Steeleworthy, Michael
name: Taylor, Sally
Publisher: name: The University of British Columbia
Year: 2019

description: The first version of the guide provides users with best practices for creating citation metadata in Dataverse. The guide provides definitions of metadata fields and clarification where needed; distinguishes between required, recommended and optional fields; and illustrates the use of each field with an example. Future editions will provide guidance for disciplinary metadata blocks in Dataverse, namely, Social Sciences and Humanities, Geospatial, Life Sciences, and Astronomy & Astrophysics Metadata.
Filtration of non-Newtonian fluids.
Creators: name: Rao, A. R. Koteswara.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1970
Subjects: subject: Engineering, Chemical.

description: In view of increasing usage and importance of non-Newtonian fluids in the chemical industries and in scientific research, an investigation into the filtration of non-Newtonian fluids was undertaken. During the course of the present investigation, filtration equipment was designed and constructed to conduct experiments to substantiate the theoretical analysis for the filtration of incompressible, time independent non-Newtonian fluids. The fundamental relationship formulated for filtration in the course of this investigation, which incorporates recent modifications of Tiller and Shirato and of Shirato et al., accounting for the variation of the superficial velocity of the liquid through the cake and the velocity of the particles of the cake associated with cake compaction, was experimentally verified and confirmed. Also experimental data were obtained to establish the viability and efficiency of an improved method of treatment in which the filtration is considered to be comprised of an initial stage and the main filtration stage yielding a convenient means of characterization of the initial stage of filtration and of its effects on filter medium and cake characteristics. Further, the usefulness of the concepts and relationships developed for filtration in the interpretation and processing of experimental data is demonstrated utilizing the data collected in the constant pressure and constant rate filtration of slurries of calcium carbonate in water and in hydroxyethyl cellulose (Natrosol 250) solutions. The filtration area of the apparatus was 4.51 x 10-2 sq. ft. and the calcium carbonate content of the slurries was 2.5 per cent by weight. The applied filtration pressure and flow rate in the constant pressure and constant rate experiments ranged between 50 to 350 psi and 2. 24 x 10-4 to 3. 29 x 10-3 ft. sec., respectively.
Detecting anomalies in fibre systems using 3-dimensional image data
Creators: name: Dresvyanskiy, Denis
name: Karaseva, Tatiana
name: Makogin, Vitalii
name: Mitrofanov, Sergei
name: Redenbach, Claudia
name: Spodarev, Evgeny
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Anomaly detection
subject: Fibre composite
subject: Directional distribution
subject: SAEM algorithm
subject: DDC 000 / Computer science, information & general works
subject: DDC 510 / Mathematics
subject: Classification
subject: Change-point problems
subject: Entropy
subject: Anomalieerkennung
subject: Klassifikation
subject: Entropie
subject: Signal

description: We consider the problem of detecting anomalies in the directional distribution of fibre materials observed in 3D images. We divide the image into a set of scanning windows and classify them into two clusters: homogeneous material and anomaly. Based on a sample of estimated local fibre directions, for each scanning window we compute several classification attributes, namely the coordinate wise means of local fibre directions, the entropy of the directional distribution, and a combination of them. We also propose a new spatial modification of the Stochastic Approximation Expectation-Maximization (SAEM) algorithm. Besides the clustering we also consider testing the significance of anomalies. To this end, we apply a change point technique for random fields and derive the exact inequalities for tail probabilities of a test statistic. The proposed methodology is first validated on simulated images. Finally, it is applied to a 3D image of a fibre reinforced polymer.
Serena Fusco, Incorporations of Chineseness. Hybridity, Bodies, and Chinese American Literature
Creators: name: Marino, Elisabetta
Publisher: name: Iperstoria
Year: 2020

description: Review of Serena Fusco, Incorporations of Chineseness. Hybridity, Bodies, and Chinese American Literature
description: Iperstoria, No 7 (2016): Old and New West
Using Word Sketch to Investigate the Lexical and Grammatical Environment of Cognates across English and Italian
Creators: name: Stewart, Dominic
Publisher: name: Iperstoria
Year: 2020

description: Word Sketches are automatic, corpus-based summaries – one or two pages in length – of a word’s grammatical and collocational behaviour. Word Sketch is one of the many facilities offered by Sketch Engine and has been extensively adopted by lexicographers in view of its detailed and visually friendly features. However, dictionaries can provide only a limited amount of information and therefore may not necessarily report specific grammatical and/or semantic features – in particular semantic prosodies – of the word in question. This paper offers a critical analysis of examples of Bilingual Word Sketch searches across English and Italian, with particular reference to cognates of the two languages with apparently similar meanings, in an attempt to shed light on the advantages and disadvantages of Word Sketch to investigate cross-language near-synonym differentiation.
description: Iperstoria, No 7 (2016): Old and New West