title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð»Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾Ð·Ð¾Ð¼ Ð°Ð½ÐºÐ¸Ð»Ð¾Ð·Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ¿Ð¾Ð½Ð´Ð¸Ð»Ð¸ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Study of the cytokine profile of patients diagnosed with ankylosing spondylitis
Creators: name: Ð¨ÐµÐ²Ð°Ð»Ð´Ð¸Ð½Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð°ÑÑÐ¾Ð¸Ð¼Ð¼ÑÐ½Ð½ÑÐµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ
Ð°Ð½ÐºÐ¸Ð»Ð¾Ð·Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐ¿Ð¾Ð½Ð´Ð¸Ð»Ð¸Ñ
Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÐÐµÑ ÑÐµÑÐµÐ²Ð°
ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ñ
Ð¸Ð½ÑÐµÑÐ»ÐµÐ¹ÐºÐ¸Ð½Ñ
Ñ ÐµÐ¼Ð¾ÐºÐ¸Ð½Ñ
Ð³Ð¾ÑÐ¼Ð¾Ð½Ñ
Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑÑ
Ð±ÑÑÐ¸ÑÐ¸Ð»Ñ Ð¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ð°
autoimmune diseases
ankylosing spondylitis
Bekhterevs disease
cytokines
interleukins
chemokine hormones
biomarkers
butyrylcholinesterase
elisa

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description: The present study constitutes a part of a comprehensive investigation aimed at identifying novel markers for the diagnosis and assessment of autoimmune pathologies, specifically ankylosing spondylitis. Ankylosing spondylitis, also known as Bechterevs disease, is a systemic chronic autoimmune inflammatory disorder characterized by the progressive immobilization of intervertebral joints, calcification of spinal ligaments, and involvement of the spinal joints, paravertebral tissues, and sacroiliac joints. The objective of this research was to investigate the hormonal and cytokine profiles, as well as the activity of butyrylcholinesterase in blood plasma. Hormone and cytokine levels were determined using enzyme immunoassay, while butyrylcholinesterase activity was measured utilizing the modified Ellman method. The results revealed significantly elevated levels of cytokines/chemokines, including IL-1Î± (311.90 Â± 146.20 pg/ml), -1Ã (26.03 (12.92; 3042)), -2 (3.25 Â± 1.06), -5 (11.33 Â± 4.14), -15 (48.53 Â± 20.34), -27 (9965.74 Â± 1155.12), M-CSF (78.99 (68.89; 89.20)), MIG (175.4 (126.1; 207.5)), and RANTES (235.57 (187.81; 249.01)), in the blood plasma of patients, as compared to the individuals in the control group. The obtained findings hold significant potential for the development of innovative diagnostic test systems and the progression towards personalized patient-oriented medicine, as well as for further exploration of the molecular pathogenesis underlying Bechterevs disease and other autoimmune rheumatic disorders.