cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Penning collisions between supersonically expanded metastable helium atoms and laser-cooled lithium atoms
Creators: name: Grzesiak, Jonas
name: Momose, Takamasa
name: Stienkemeier, Frank
name: Mudrich, Marcel
name: Dulitz, Katrin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We describe an experimental setup comprised of a discharge source for supersonic beams of metastable helium atoms and a magneto-optical trap (MOT) for ultracold lithium atoms that makes it possible to study Penning ionization and associative ionization processes at high ion count rates. The cationic reaction products are analyzed using a novel ion detection scheme which allows for mass selection, a high ion extraction efficiency and a good collision-energy resolution. The influence of elastic He-Li collisions on the steady-state Li atom number in the MOT is described, and the collision data are used to estimate the excitation efficiency of the discharge source. We also show that Penning collisions can be directly used to probe the temperature of the Li cloud without the need for an additional time-resolved absorption or fluorescence detection system.
description: accepted by J. Chem. Phys. (Dec. 2018)
On separate chemical freeze-outs of hadrons and light (anti)nuclei in high energy nuclear collisions
Creators: name: Bugaev, K. A.
name: Grinyuk, B. E.
name: Ivanytskyi, A. I.
name: Sagun, V. V.
name: Savchenko, D. O.
name: Zinovjev, G. M.
name: Nikonov, E. G.
name: Bravina, L. V.
name: Zabrodin, E. E.
name: Blaschke, D. B.
name: Kabana, S.
name: Taranenko, A. V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The multiplicities of light (anti)nuclei were measured recently by the ALICE collaboration in Pb+Pb collisions at the center-of-mass collision energy $\sqrt{s_{NN}} =2.76$ TeV. Surprisingly, the hadron resonance gas model is able to perfectly describe their multiplicities under various assumptions. For instance, one can consider the (anti)nuclei with a vanishing hard-core radius (as the point-like particles) or with the hard-core radius of proton, but the fit quality is the same for these assumptions. In this paper we assume the hard-core radius of nuclei consisting of $A$ baryons or antibaryons to follow the simple law $R(A) = R_b (A)^\frac{1}{3}$, where $R_b$ is the hard-core radius of nucleon. To implement such a relation into the hadron resonance gas model we employ the induced surface tension concept and analyze the hadronic and (anti)nuclei multiplicities measured by the ALICE collaboration. The hadron resonance gas model with the induced surface tension allows us to verify different scenarios of chemical freeze-out of (anti)nuclei. It is shown that the most successful description of hadrons can be achieved at the chemical freeze-out temperature $T_h=150$ MeV, while the one for all (anti)nuclei is $T_A=168.5$ MeV. Possible explanations of this high temperature of (anti)nuclei chemical freeze-out are discussed.
description: 6 pages, 1 figure
title: Continuous Krapcho Dealkoxycarbonylation in API Synthesis
Creators: name: Rehbein, Moritz
name: Husmann, Sascha
name: Wolters, J.
name: Priess, L.
name: Lechner, C.
name: Kunick, Conrad
name: Scholl, Stephan
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Flow synthesis, process intensification, Krapcho dealkoxycarbonylation
subject: 615.19
subject: 660

description: A high pressure and high temperature continuous flow reactor has been used to intensify a Krapcho dealkoxycarbonylation
reaction in the context of API synthesis. The reactor enables operation of the reaction above temperatures
possible in batch and thus significantly increased conversion rates are achieved. Also a broader choice of solvents is
possible by the use of the continuous process. Batch and continuous reaction are compared in terms of operation range
and space-time-yield. Despite lower concentrations of the reactants in the continuous process, space-time-yield exceeds
that of the batch process by more than an order of magnitude due to the higher reaction rates.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Changing predictors of statin initiation in US women over two decades
Creators: name: Glynn, R.J.
name: Kinsey, T.L.
name: Stürmer, T.
name: Poole, C.
name: Rothman, K.J.
Publisher: name: John Wiley and Sons Ltd
Year: 2019

description: Purpose: To describe changing roles of predictors of statin initiation before and after incident coronary heart disease, and before and after publication of National Cholesterol Education Program Adult Treatment Panel-III (ATP-III) guidelines in a cohort of US women. Methods: We identified 34 382 women enrolled into the Women's Health Study from 1993 to 1995 and followed up until 2012. Proportions of previous nonusers initiating statins were described over time. We used multivariable linear regression models to estimate adjusted initiation proportion differences (IPDs) for initiation overall, separately before and after incident coronary heart disease, and separately for ATP-II and ATP-III time periods. Results: Key predictors of initiation overall were self-reported total cholesterol, and previous incident coronary heart disease, cerebrovascular disease, and diabetes. Adjusted IPDs (percentage) for total cholesterol > 240 vs <200 mg/dL were 7.5 (95% confidence interval [CI], 7.0-8.0) and 9.3 (95% CI, 8.7-9.9) during ATP-II and ATP-III time periods, respectively. Adjusted IPDs in women with diabetes were 7.0 (95% CI, 6.3-7.8) and 11.9 (95% CI, 6.7-17.0) for primary and secondary prevention, respectively, and 3.1 (95% CI, 2.1-4.0) and 9.2 (95% CI 8.2-10.2) for before and after ATP-III, respectively. Conclusions: Secular trends reflected evolution toward risk factor-based treatment indications for statin initiation with increased initiation among diabetics and women with normal and borderline cholesterol. The role of serum cholesterol changed over time, though the character was scale (multiplicative vs additive) dependent. In pharmacoepidemiologic studies of statins, strength of confounding by important variables sometimes unmeasured in claims data, such as cholesterol level, may be calendar time dependent.
Ground-State Magnetization in Disordered Systems : Exchange vs. Off-Diagonal Interaction Fluctuations
Creators: name: Jacquod, Philippe
name: Stone, A. Douglas
Publisher: name: arXiv
Year: 2000
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Chaotic Dynamics (nlin.CD)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In a Hartree-Fock picture, itinerant ferromagnetism results from a competition between kinetic and exchange energy, with the magnetized state being favored at large interaction strength. In a recent paper \cite{spings} we showed that in contrast to this average effect, fluctuations of off-diagonal interaction matrix elements systematically reduce the ground-state magnetization. When the interaction dominates, the occurence of a non-zero ground-state magnetization depends on the ratio $λ$ between average exchange energy and the fluctuation amplitude of the off-diagonal matrix elements, and a nonzero critical value $λ_c$ is necessary to magnetize the ground-state. We extend these results by numerical studies of $λ$ for standard tight-binding models which indicate a regime of intermediate disorder where off-diagonal fluctuations should play an important role for ground-state magnetization. We also emphasize the presence of strong correlations between minimal eigenvalues of different magnetization blocks which further reduce the probability of a nonzero ground-state spin.
description: Talk presented at the VIIIth International Conference on "Hopping and Related Phenomena", September 99, Murcia, Spain. Will appear in the proceedings : Phys. Stat. Sol. (2000)
Evidence for coexisting shapes in $^{98}$Zr through lifetime measurements
Creators: name: Singh, Purnima
name: Korten, W.
name: Hagen, T. W.
name: Görgen, A.
name: Grente, L.
name: Salsac, M. -D.
name: Farget, F.
name: Clément, E.
name: de France, G.
name: Braunroth, T.
name: Bruyneel, B.
name: Celikovic, I.
name: Delaune, O.
name: Dewald, A.
name: Dijon, A.
name: Delaroche, J. -P.
name: Girod, M.
name: Hackstein, M.
name: Jacquot, B.
name: Libert, J.
name: Litzinger, J.
name: Ljungvall, J.
name: Louchart, C.
name: Gottardo, A.
name: Michelagnoli, C.
name: Müller-Gatermann, C.
name: Napoli, D. R.
name: Otsuka, T.
name: Pillet, N.
name: Recchia, F.
name: Rother, W.
name: Sahin, E.
name: Siem, S.
name: Sulignano, B.
name: Togashi, T.
name: Tsunoda, Y.
name: Theisen, Ch.
name: Valiente-Dobon, J. J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The lifetimes of first excited 2$^+$, 4$^+$ and 6$^+$ states in $^{98}$Zr were measured with the Recoil-Distance Doppler Shift method in an experiment performed at GANIL. Excited states in $^{98}$Zr were populated using the fission reaction between a 6.2 MeV/u $^{238}$U beam and a $^{9}$Be target. The $γ$ rays were detected with the EXOGAM array in correlation with the fission fragments identified in mass and atomic number in the VAMOS++ spectrometer. Our result shows very small B(E2;2$_1^+$ $\rightarrow$ 0$_1^+$) value in $^{98}$Zr thereby confirming the very sudden onset of collectivity at $N=60$. The experimental results are compared to large-scale Monte Carlo Shell model and beyond mean field calculations. The present results indicate coexistence of two additional deformed shapes in this nucleus along with the spherical ground state.
title: An Avalanche Transistor-Based Pulse Generator Design For Infrared Laser Applications
Creators: name: Lopez, Abraham
Publisher: name: University of Nevada, Las Vegas
publisherIdentifier: https://ror.org/0406gha72
publisherIdentifierScheme: ROR
Year: 2023

description: This thesis details the design and results of a circuit intended for infrared laser applications, specifically for transcranial infrared light simulation (TILS) experiments and for use as a range finder. The circuit itself is comprised of a transistor, high voltage power supply, laser diode, capacitor, resistor, diode, and low voltage pulse. The design of a range finder is also developed. The range finder design is the same as the circuit developed for TILs with the addition of a few more components for receiving the returned light pulse such as a photodiode, op-amp, and comparator. The techniques used for a successful circuit design are described. For the TILS experiments the design must be able to output a very-high amplitude current pulse in a short amount of time, nanoseconds to picoseconds, to the laser diode. It is shown, and discussed, that the size of the capacitor, the value of the high voltage supply, and the switching characteristics of transistor used, determine the characteristics of the circuit’s output pulse. For the second design presented in this thesis, the range finder, the circuit operates by measuring the time difference, using an oscilloscope, between the output of the transmitter circuit and the output of the comparator. The comparator output is a square voltage pulse signifying a received laser pulse from the laser diode once the light reaches the photodiode. Once the time is measured it is used to calculate distance, where it is shown and discussed the range finder’s performance from distances of centimeters to meters.
АКТУАЛЬНОСТЬ ИНТЕРАКТИВНОГО ОБУЧЕНИЯ В ВУЗАХ УЗБЕКИСТАНА
Creators: name: Йулдашева, Гулбахор
Publisher: name: Zenodo
Year: 2025

description: В статье рассматриваются актуальные вопросы внедрения интерактивного обучения в систему высшего образования Республики Узбекистан. Особое внимание уделяется теоретическим и методическим основаниям интерактивных технологий, их значению в формировании профессиональных и надпрофессиональных компетенций студентов, а также результатам внедрения интерактивных методов в педагогический процесс. Представлен анализ нормативных документов, стратегических программ и образовательных реформ, направленных на модернизацию вузовского образования. Раскрыты барьеры и возможности практического применения интерактивных методик, а также обозначены перспективные направления их развития.
Considerations for Pharmacoepidemiological Studies of Drug–Cancer Associations
Creators: name: Friis, S.
name: Pottegård, A.
name: Stürmer, T.
name: Hallas, J.
name: Bahmanyar, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspectives. Aspects of data sources include assessment of complete history of drug use and data on dose and duration of drug use, allowing estimates of cumulative exposure. Outcome data from formal cancer registries are preferable, but cancer data from other sources, for example, patient or pathology registries, medical records or claims are also suitable. The two principal designs for observational studies evaluating drug–cancer associations are the cohort and case–control designs. A key challenge in studies of drug–cancer associations is the exposure assessment due to the typically long period of cancer development. We present methods to examine early and late effects of drug use on cancer development and discuss the need for employing ‘lag-time’ in order to avoid reverse causation. We emphasize that a new-user study design should always be considered. We also underline the need for ‘dose–response’ analyses, as drug–cancer associations are likely to be dose-dependent. Generally, studies of drug–cancer associations should explore risk of site-specific cancer, rather than cancer overall. Additional differentiation may also be crucial for organ-specific cancer with various distinct histological subtypes (e.g., lung or ovary cancer). We also highlight the influence of confounding factors and discuss various methods to address confounding, while emphasizing that the choices of methods depend on the design and specific objectives of the individual study. In some studies, use of active comparator(s) may be preferable. Pharmacoepidemiological studies of drug–cancer associations are expected to evolve considerably in the coming years, due to the increasing availability of long-term data on drug exposures and cancer outcomes, the increasing conduct of multinational studies, allowing studies of rare cancers and subtypes of cancer, and methodological improvements specifically addressing cancer and other long-term outcomes.
Evidence for degenerate mirrorless lasing in alkali metal vapor: forward beam magneto-optical experiment
Creators: name: Papoyan, Aram
name: Shmavonyan, Svetlana
name: Khanbekyan, Aleksandr
name: Azizbekyan, Hrayr
name: Movsisyan, Marina
name: Bao, Guzhi
name: Kanta, Dimitra
name: Wickenbrock, Arne
name: Budker, Dmitry
Publisher: name: arXiv
Year: 2018
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report an experimental observation of degenerate mirrorless lasing in forward direction under excitation of a dilute atomic Rb vapor with a single linearly polarized cw laser light resonant with cycling Fe > Fg atomic D2 transitions. Light polarized orthogonally to the laser light is generated for the input light intensity exceeding a threshold value of about 3 mW/cm^2. Application of a transverse magnetic field directed along the input light polarization reveals a sharp about 20 mG wide magnetic resonance centered at B = 0. Increasing the incident light intensity from 3 to 300 mW/cm^2, the generated light undergoes rapid amplitude increase followed by a decline and resonance broadening. Such nonlinear behavior of the observed magnetic resonance is attributed to the population inversion on optical transitions between magnetic sublevels established under linearly polarized excitation. We present observations that indicate that a combination of nonlinear-optical effects occurs in this system, including degenerate mirrorless lasing and four-wave mixing.
Limnesia (Limnesia) jolova Cook 1986
Creators: name: Smit, Harry
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Limnesiidae
Limnesia
Limnesia jolova

description: Limnesia (Limnesia) jolova Cook, 1986   New record — New South Wales. 2/0/0, Waterfall Creek at Gunulla Flat, Royal NP, 8
Nov. 2001.
 Distribution — Thus far known only from the holotype male collected in Queensland and reported here for the first time from New South Wales.
description: Published as part of Smit, Harry, 2022, New records of water mites of the family Limnesiidae Thor from Australia (Acari: Hydrachnidia), with the description of seven new species, pp. 193-222 in Acarologia 62 (1) on page 201, DOI: 10.24349/yu9v-w0lf, http://zenodo.org/record/7160186
Injection testosterone and adverse cardiovascular events: A case-crossover analysis
Creators: name: Stürmer, T.
name: Meier, C.R.
name: Layton, J.B
name: Li, D.
name: Brookhart, M.A.
name: Sharpless, J.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Context: Exogenous testosterone administration may affect blood clotting, polycythaemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short-term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms. Objective: We sought to evaluate the short-term cardiovascular risk of receiving injection testosterone. Design: We conducted a case-crossover analysis comparing injection testosterone exposure in the 7 days prior to an outcome event to referent windows in the past to estimate the acute association of cardiovascular outcomes with the receipt of testosterone injections. Patients: We identified adult male testosterone users hospitalized with myocardial infarction (MI), stroke or a composite of MI, stroke or unstable angina in US commercial claims (2000-2013) or Medicare (2007-2010) databases. Measurements: We identified testosterone use for the patients from pharmacy dispensing claims or in-office procedure codes in the insurance billing data. Results: We identified 2898 commercially insured men with events and recent testosterone use, and 339 from Medicare. Injected testosterone was associated with an increased risk of adverse events (composite outcome of myocardial infarction, stroke or unstable angina) in the immediate postinjection period for the older, Medicare population only: commercial insurance, odds ratios (OR) = 0.98 (95% confidence intervals [CI]: 0.86-1.12); Medicare, OR = 1.45 (1.07, 1.98). This association was either greatly attenuated or not present when evaluating receipt of any testosterone dosage forms (injection, gel, patch, implant): commercial insurance, OR = 1.01 (0.92, 1.11); Medicare, OR = 1.26 (95% CI: 0.98-1.63). Conclusions: Testosterone injections were uniquely associated with short-term risk of acute cardio- and cerebrovascular events in older adult men following injection receipt.
Extended Drag-Based Model for better predicting the evolution of Coronal Mass Ejections
Creators: name: Rossi, Mattia
name: Guastavino, Sabrina
name: Piana, Michele
name: Massone, Anna Maria
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences
subject: 85-10

description: The solar wind drag-based model is a widely used framework for predicting the propagation of Coronal Mass Ejections (CMEs) through interplanetary space. This model primarily considers the aerodynamic drag exerted by the solar wind on CMEs. However, factors like magnetic forces, pressure gradients, and the internal dynamics within CMEs justify the need of introducing an additional small-scale acceleration term in the game. Indeed, by accounting for this extra acceleration, the extended drag-based model is shown to offer improved accuracy in describing the evolution of CMEs through the heliosphere and, in turn, in forecasting CME trajectories and arrival times at Earth. This enhancement is crucial for better predicting Space Weather events and mitigating their potential impacts on space-based and terrestrial technologies.
title: Influence of amorphous solid Dispersions of Paracetamol and PVP VA 64 on the thermoresponsive Behaviour of the Polymer
Creators: name: Ritters, Lena
name: Reichl, Stephan
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: amorphous solid dispersion, thermoresponsive polymer, dissolution, lower critical solution temperature
subject: 615.19
subject: 660

description: The dissolution of spray-dried amorphous solid dispersions consisting of paracetamol and PVP VA 64 at room
temperature leads to the formation of different systems, depending on the drug/polymer ratio. Aqueous systems at room
temperature with poor paracetamol/PVP VA 64 ratio are transparent solutions, while higher drug loads lead to phase
separation of the solution. PVP VA 64 is known as thermoresponsive polymer. The aim of the study was to investigate
the dissolution behaviour of these amorphous solid dispersions in water and their influence on the thermoresponsive
behaviour of this polymer. Therefore, the demixing temperature was determined using DSC, since a change in the system
constitutes an endothermic process. It could be shown that PVP VA 64 has lower critical solution temperature (LCST)
behaviour around 70 °C, which decreases with increasing content of paracetamol due to the complex formation between
the polymer and paracetamol.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Treating pediatric anxiety: Initial use of SSRIs and other antianxiety prescription medications
Creators: name: Dusetzina, S.B.
name: Gaynes, B.N.
name: Walkup, J.T.
name: Bushnell, G.A.
name: Compton, S.N.
name: Sturmer, T.
name: Brookhart, M.A.
name: Rynn, M.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Objective: Multiple pharmacotherapies for treating anxiety disorders exist, including selective serotonin reuptake inhibitors (SSRIs), the recommended first-line pharmacotherapy for pediatric anxiety. We sought to describe initial antianxiety medication use in children and estimate how long antianxiety medications were continued. Methods: In a large commercial claims database, we identified children (3-17 years) initiating prescription antianxiety medication from 2004 to 2014 with a recent anxiety diagnosis (ICD-9-CM = 293.84, 300.0x, 300.2x, 300.3x, 309.21, 309.81, 313.23). We estimated the proportion of children initiating each medication class across the study period and used multivariable regression to evaluate factors associated with initiation with an SSRI. We evaluated treatment length for each initial medication class. Results: Of 84,500 children initiating antianxiety medication, 70% initiated with an SSRI (63% [95% CI, 62%-63%] SSRI alone, 7% [95% CI, 7%-7%] SSRI + another antianxiety medication). Non-SSRI medications initiated included benzodiazepines (8%), non-SSRI antidepressants (7%), hydroxyzine (4%), and atypical antipsychotics (3%). Anxiety disorder, age, provider type, and comorbid diagnoses were associated with initial medication class. The proportion of children refilling their initial medication ranged from 19% (95% CI, 18%-20%) of hydroxyzine initiators and 25% (95% CI, 24%-26%) of benzodiazepine initiators to 81% (95% CI, 80%-81%) of SSRI initiators. Over half (55%, 95% CI, 55%-56%) of SSRI initiators continued SSRI treatment for 6 months. Conclusions: SSRIs are the most commonly used first-line medication for pediatric anxiety disorders, with about half of SSRI initiators continuing treatment for 6 months. Still, a third began therapy on a non-SSRI medication, for which there is limited evidence of effectiveness for pediatric anxiety, and a notable proportion of children initiated with 2 antianxiety medication classes.
title: Ligands for M-NHC Synthesis: Continuous Flow Di-N-Alkylation of 1H-Benzimidazole in a fixed Bed Reactor
Creators: name: Sauk, Tobias
name: Heiduk, Caroline
name: Henke, L.
name: Xiao, C.
name: Scholl, Stephan
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Continuous flow synthesis, fixed bed reactor, heterogeneous synthesis, 1H-benzimidazole
subject: 615.19
subject: 660

description: The successful transfer from batch to a continuous flow process in a fixed bed reactor of a ligand in metalorganic API
synthesis, the diazolium salt 1,3-methyl-benzoimidazol-3-ium iodide, is presented. Results show similar yields and
conversion rates at corresponding process parameters in batch and continuous mode. By exceeding temperature limitation
of a non-pressurized batch process, the pressurized continuous reactor system shows the potential for outperforming the
batch synthesis regarding space time yield. Hence, process intensification by continuous flow presents itself as a viable
approach for the heterogeneous di-N-alkylation of diazoles. Alternative basic reagents and solvents further enhance the
viability of a continuous approach by addressing limitations such as side reactions and solubility of the reagent.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Approaches to Address Premature Death of Patients When Assessing Patterns of Use of Health Care Services after an Index Event
Creators: name: Simpson, R.J.
name: Brookhart, M.A.
name: Kucharska-Newton, A.
name: Stürmer, T.
name: Fang, G.
name: Bush, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Background: Studies of the use of health care after the onset of disease are important for assessing quality of care, treatment disparities, and guideline compliance. Cohort definition and analysis method are important considerations for the generalizability and validity of study results. We compared different approaches for cohort definition (restriction by survival time vs. comorbidity score) and analysis method [Kaplan-Meier (KM) vs. competing risk] when assessing patterns of guideline adoption in elderly patients. Methods: Medicare beneficiaries aged 65-95 years old who had an acute myocardial infarction (AMI) in 2008 were eligible for this study. Beneficiaries with substantial frailty or an AMI in the prior year were excluded. We compared KM with competing risk estimates of guideline adoption during the first year post-AMI. Results: At 1-year post-AMI, 14.2% [95% confidence interval (CI), 14.0%-14.5%) of beneficiaries overall initiated cardiac rehabilitation when using competing risk analysis and 15.1% (95% CI, 14.8%-15.3%) from the KM analysis. Guideline medication adoption was estimated as 52.3% (95% CI, 52.0%-52.7%) and 53.4% (95% CI, 53.1%-53.8%) for competing risk and KM methods, respectively. Mortality was 17.0% (95%CI, 16.8%-17.3%) at 1 year post-AMI. The difference in cardiac rehabilitation initiation at 1-year post-AMI from the overall population was 0.1%, 1.7%, and 1.9% compared with 30-day survivor, 1-year survivor, and comorbidity-score restricted populations, respectively. Conclusions: In this study, the KM method consistently overestimated the competing risk method. Competing risk approaches avoid unrealistic mortality assumptions and lead to interpretations of estimates that are more meaningful.
On some groupoids of small orders with Bol-Moufang type of identities
Creators: name: Chernov, Vladimir
name: Moldovyan, Alexander
name: Shcherbacov, Victor
Publisher: name: arXiv
Year: 2018
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20N05 20N02

description: We count number of groupoids of order 3 with some Bol-Moufang type identities.
description: 5 pages
title: PEG-ylated parenteral Nanoemulsions as prospective Carriers for enhanced Brain Delivery with Diazepam as a Model Drug - Physicochemical Characterisation
Creators: name: Đoković, J.
name: Konkel, M.
name: Mitrović, J.
name: Savic, S.
name: Watrobska-Swietlikowska, D.
name: Cekić, N.
name: Savić, S.
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: PEGylated nanoemulsions, diazepam, physicochemical characterization, in vitro release
subject: 615.19
subject: 660

description: Parenteral nanoemulsions are regarded as biocompatible drug delivery systems for lypophilic drugs. When it comes to
delivering actives to the brain as a target site, prolonged circulation time is desirable. The objective of this study was to
conduct physicochemical characterization of PEGylated nanoemulsions as prospective carriers for enhanced brain
delivery, using diazepam as a model active substance for brain targeting. Nanoemulsions were prepared by high
pressure homogenization method and characterized regarding droplet size, zeta potential, pH, conductivity, viscosity
and in vitro release profile. PEG2000-DSPE and PEG5000-DPPE were used for PEGylation. All the formulations were
autoclaved and stored at room temperature. After 2 months there were no significant changes in physicochemical
parameters in autoclaved formulations which rendered them as good potential templates to incorporate drugs for brain
targeted delivery.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Directional data analysis using the spherical Cauchy and the Poisson kernel-based distribution
Creators: name: Tsagris, Michail
name: Papastamoulis, Panagiotis
name: Kato, Shogo
Publisher: name: arXiv
Year: 2024
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In 2020, two novel distributions for the analysis of directional data were introduced: the spherical Cauchy distribution and the Poisson kernel-based distribution. This paper provides a detailed exploration of both distributions within various analytical frameworks. To enhance the practical utility of these distributions, alternative parametrizations that offer advantages in numerical stability and parameter estimation are presented, such as implementation of the Newton-Raphson algorithm for parameter estimation, while facilitating a more efficient and simplified approach in the regression framework. Additionally, a two-sample location test based on the log-likelihood ratio test is introduced. This test is designed to assess whether the location parameters of two populations can be assumed equal. The maximum likelihood discriminant analysis framework is developed for classification purposes, and finally, the problem of clustering directional data is addressed, by fitting finite mixtures of Spherical Cauchy or Poisson kernel-based distributions. Empirical validation is conducted through comprehensive simulation studies and real data applications, wherein the performance of the spherical Cauchy and Poisson kernel-based distributions is systematically compared.
Teacher mental health and workplace well-being in a global crisis: Learning from the challenges and supports identified by teachers one year into the COVID-19 pandemic in British Columbia, Canada
Creators: name: Gadermann, Anne M
name: Petteni, Monique Gagné
name: Molyneux, Tonje M
name: Warren, Michael T
name: Thomson, Kimberly C
name: Schonert-Reichl, Kimberly
name: Guhn, Martin
name: Oberle, Eva
Publisher: name: University of Illinois at Chicago
Year: 2024
Subjects: classificationCode: 39
subject: Education
classificationCode: 4203
subject: Health services and systems
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: The COVID-19 pandemic and related school disruptions have led to increased concerns for the mental health of teachers. This study investigated how the challenges and systemic supports perceived by teachers during the COVID-19 pandemic were associated with their mental health and workplace well-being. This cross-sectional, survey-based study was conducted in February 2021, just prior to the third wave of the pandemic in British Columbia (BC), Canada (N = 1,276). Four multivariable linear regression models examined the associations between teachers' pandemic-related challenges (pandemic-related personal stressors, teacher workload, difficulty implementing safety measures, meeting students' needs), systemic supports (education system mental health and well-being support), and four mental health (psychological distress, and quality of life) and workplace well-being outcomes (job-related positive affect, turnover intentions), adjusting for sociodemographic and school characteristics. The Pratt index (d) was used to assess the relative importance of each predictor. A thematic qualitative analysis was conducted on teachers' open-ended responses. Teachers' workplace well-being (job-related positive affect and turnover intentions) was predominantly associated with their perceptions of education system support for their mental health and well-being (d = 46%, d = 41%, respectively). The most important predictor of general mental health (psychological distress and quality of life) was the number of COVID-19 related personal stressors teachers reported (d = 64%, d = 43%, respectively). The qualitative analyses corroborated and expanded upon the quantitative findings. Understanding pandemic-related challenges and supports impacting teacher mental health and workplace well-being equips us to make evidence-informed policy decisions to support teachers now and in future school disruptions.
Almost Non-positive Kähler Manifolds
Creators: name: Zhang, Yuguang
Publisher: name: arXiv
Year: 2024
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: This paper proves that the universal covering of a compact Kähler manifold with small positive sectional curvature in a certain sense is contractible.
Limnesia szalayi K. Viets 1955, syn. nov.
Creators: name: Smit, Harry
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Limnesiidae
Limnesia
Limnesia szalayi

description: Limnesia szalayi K. Viets, 1955 syn. nov.
 Material examined — Limnesia patens. Syntypes: Two males, three deutonymphs, Kratersee Telaga, Buitenzorg, Java, 21.11.1928, (Type, slide 45621, SMF); two males, one female, Sindanglaja Quelle, Buitenzorg, Java, 21.11.1928 (Types, slide 45622, SMF). Limnesia szalayi. Holotype female, Kuranda, N Queensland, Laird coll., 13.6.54 (slide 45696, SMF).
 New record — Queensland. 1/1/0, Spear Creek at crossing with Bypass Road, Cape York Peninsula, 12°03.206′ S 142°39.138′ E, 76 m a.s.l., 23 Oct. 2014.
 Remarks — The specimens from this study match the description of K. Viets (1935) well. K. Viets (1955) described a very similar species from northern Queensland, i.e. L. szalayi. The description of the latter species was based on one female only, and Viets didn′t compare it with other species. Moreover, the holotype of L. szalayi was fixed in ethanol, which makes it often difficult to see the morphological structures well. Cook (1986) noticed the similarity between the two species. When comparing the original descriptions, the only difference I find between the two species is that L. patens has no posteromedial platelet (K. Viets 1935), and in L. szalayi an indistinct platelet should be present (K. Viets 1955). I examined the holotype and only known specimen thus far of L. szalayi, but I do not see a posteromedial platelet. In the shape of palp and genital field the two species are identical. Therefore, I propose to synonymize L. szalayi with L patens.
 Distribution — Limnesia patens is widespread, and has been reported from Java, Indonesia (K. Viets 1935), India (Cook 1967) and Burma (Lundblad 1969). Within Australia known only from Queensland.
description: Published as part of Smit, Harry, 2022, New records of water mites of the family Limnesiidae Thor from Australia (Acari: Hydrachnidia), with the description of seven new species, pp. 193-222 in Acarologia 62 (1) on page 205, DOI: 10.24349/yu9v-w0lf, http://zenodo.org/record/7160186
Examining Parental Medication Adherence as a Predictor of Child Medication Adherence in Pediatric Anxiety Disorders
Creators: name: Dusetzina, S.B.
name: Brookhart, M.A.
name: Gaynes, B.N.
name: Bushnell, G.A.
name: Stürmer, T.
name: Compton, S.N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Background: Selective serotonin reuptake inhibitors (SSRIs) are the recommended first-line pharmacotherapy for pediatric anxiety disorders but adherence remains difficult to predict. Objectives: To estimate SSRI adherence in children with anxiety disorders and determine if prior parental medication adherence is predictive of child high SSRI adherence. Methods: We identified children (3-17 y) initiating SSRI treatment after an anxiety disorder diagnosis in a commercial claims database (2005-2014). We evaluated parent SSRI, statin, and antihypertensive adherence [6-mo proportion days covered (PDC), high adherence=PDC≥0.80] in the year before child SSRI initiation. We estimated risk differences (RD) of child high SSRI adherence (6-mo PDC) stratified by parent adherence and multivariable risk ratios using modified Poisson regression. We estimated change in c-statistic and risk reclassification when adding parent-level covariates with child-level covariates to predict child adherence. Results: In 70,979 children with an anxiety disorder (59%=female, 14=median age), the mean 6-month SSRI PDC was 0.72, with variation by anxiety disorder. Overall 64% of children had high adherence if their parent had high SSRI adherence versus 53% of children with parents with low SSRI adherence (RD, 12%; multivariable risk ratios, 1.17; 95% confidence interval, 1.14-1.20). Findings were similar for parent statin (RD=10%) and antihypertensive adherence (RD=8%) and when stratified by child age and parent sex. There was minor improvement in risk reclassification and the c-statistic after adding parent adherence and parent-level covariates. Conclusions: Parental medication adherence could help providers identify children at risk of nonadherence to inform the treatment decision, reduce unnecessary medication switches, and lead to broader effective interventions.
title: Particle based Cultivation of Lentzea aerocolonigenes in Membrane aerated stirred Bioreactors for increased Rebeccamycin Production
Creators: name: Schrinner, Kathrin
name: Schrader, Marcel
name: Niebusch, Jana
name: Wurzler, Nadine
name: Kwade, Arno
name: Krull, Rainer
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: membrane aeration, filamentous microorganisms, particle enhanced cultivation, mechanical stress
subject: 615.19
subject: 660

description: Filamentous microorganisms represent the majority of natural producers of antibiotics and other active pharmaceutical ingredients (APIs). Lentzea aerocolonigenes is a filamentous actinomycete producing the antitumor antibiotic rebeccamycin. The addition of glass beads (100 g/L, ⌀ = 969 μm) in shake flask cultivations led to a significant increase in rebeccamycin production compared to an unsupplemented cultivation by inducing mechanical stress. To achieve larger amounts of rebeccamycin a scale-up was conducted. A bubble free membrane aeration was chosen to reduce the power input to stirrer and particle induced stress. Glass bead addition (50 g/L, ⌀ = 969 μm) in this membrane aerated stirred bioreactor increased rebeccamycin concentration compared to an unsupplemented cultivation as well. Moreover it reduced biomass growth on the aeration membrane which is a widespread challenge in membrane aerated bioreactors.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Who diagnosed and prescribed what? Using provider details to inform observational research
Creators: name: Stürmer, T.
name: Pate, V.
name: Miller, M.
name: Bushnell, G.A.
name: Mack, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Purpose: To describe how often patients with depression initiating antidepressants receive their depression diagnosis and prescriptions from the same provider and, when simultaneously initiating benzodiazepines, how often both prescriptions come from the same provider. Methods: Using a US healthcare claims database, we created a cohort of adults (18-64 years) with a depression diagnosis who initiated antidepressants. We examined concordance by provider specialty and provider identifier between (a) the first antidepressant prescription fill and most proximal depression diagnosis, and (b) the initial antidepressant and benzodiazepine prescription fills among simultaneous benzodiazepine and antidepressant initiators. Results: Among 245 166 antidepressant initiators with a recent depression diagnosis (female = 67%; median age = 39), the specialty of the provider assigning the depression diagnosis matched the antidepressant prescriber's specialty in 94% of cases with known provider details (provider identifier concordance = 93%). Concordance was higher for adults diagnosed by a general practitioner (98%) or psychiatrist (92%) than for those diagnosed by a psychologist (74%). In simultaneous new users of antidepressants and benzodiazepines (n = 19 371), both prescriptions were issued by the same provider specialty and provider identifier 94% and 93% of the time, respectively. Conclusions: The vast majority of patients who received antidepressant prescriptions and depression diagnoses appear to have received both diagnosis and antidepressants from the same provider, suggesting that when antidepressants are issued around the time a patient is diagnosed with depression, the antidepressant was likely prescribed for depression. In addition, the great majority of patients who simultaneously initiate benzodiazepines appear to do so under the direction of one provider.
The Quantum Modular Group in (2+1)-Dimensional Gravity
Creators: name: Carlip, S.
name: Nelson, J. E.
Publisher: name: arXiv
Year: 1998
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The role of the modular group in the holonomy representation of (2+1)-dimensional quantum gravity is studied. This representation can be viewed as a "Heisenberg picture", and for simple topologies, the transformation to the ADM "Schr{ö}dinger picture" may be found. For spacetimes with the spatial topology of a torus, this transformation and an explicit operator representation of the mapping class group are constructed. It is shown that the quantum modular group splits the holonomy representation Hilbert space into physically equivalent orthogonal ``fundamental regions'' that are interchanged by modular transformations.
description: 23 pages, LaTeX, no figures; minor changes and clarifications in response to referee (basic argument and conclusions unaffected)
ZTF SN Ia DR2: The diversity and relative rates of the thermonuclear SN population
Creators: name: Dimitriadis, G.
name: Burgaz, U.
name: Deckers, M.
name: Maguire, K.
name: Johansson, J.
name: Smith, M.
name: Rigault, M.
name: Frohmaier, C.
name: Sollerman, J.
name: Galbany, L.
name: Kim, Y. -L.
name: Liu, C.
name: Miller, A. A.
name: Nugent, P. E.
name: Alburai, A.
name: Chen, P.
name: Dhawan, S.
name: Ginolin, M.
name: Goobar, A.
name: Groom, S. L.
name: Harvey, L.
name: Kenworthy, W. D.
name: Kulkarni, S. R.
name: Phan, K.
name: Popovic, B.
name: Riddle, R. L.
name: Rusholme, B.
name: Muller-Bravo, T. E.
name: Nordin, J.
name: Terwel, J. H.
name: Townsend, A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Zwicky Transient Facility SN Ia Data Release 2 (ZTF SN Ia DR2) contains more than 3,000 Type Ia supernovae (SNe Ia), providing the largest homogeneous low-redshift sample of SNe Ia. Having at least one spectrum per event, this data collection is ideal for large-scale statistical studies of the photometric, spectroscopic and host-galaxy properties of SNe Ia, particularly of the rarer 'peculiar' sub-classes. In this paper we first present the method we developed to spectroscopically classify the SNe in the sample, and the techniques we used to model their multi-band light curves and explore their photometric properties. We then show a method to distinguish between the peculiar sub-types and the normal SNe Ia. We also explore the properties of their host galaxies and estimate their relative rates, focusing on the peculiar sub-types and their connection to the cosmologically useful SNe Ia. Finally, we discuss the implications of our study with respect to the progenitor systems of the peculiar SN Ia events.
description: 20 pages, 13 figures, final version in Astronomy and Astrophysics
Variation of Acoustic Power with Magnetic Field as seen in Gong+ Data
Creators: name: Venkatakrishnan, P.
name: Kumar, Brajesh
name: Tripathy, S. C.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The acoustic spectra in sunspots are known to be richer in higher frequency power. We have attempted a generalized study of the effect of magnetic fields on the shape of the acoustic spectrum using GONG+ bread-board data (spatial scale of ~ 2 arc-sec per pixel) of 11 May, 2000 and 12 June, 2000. The mean power spectra of the velocity oscillations were obtained by averaging over several spectra for different values of the magnetic field. With increasing magnetic field, the acoustic power increases at higher frequencies and decreases at lower frequencies with a transition at ~= 5 mHz. This behaviour is slightly different from earlier results obtained from SOHO/MDI data.
description: 6 pages, 3 figures, To appear in Solar Physics
title: Parameter Identifiability of Artemisinin Synthesis using Design of Experiments
Creators: name: Schulze, Moritz
name: Triemer, Susann
name: Schenkendorf, René
name: Seidel-Morgenstern, Andreas
name: Krewer, Ulrike
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: parameter identifiability, design of experiments, parameter sensitivities, singular value decomposition, antimalarial artemisinin synthesis
subject: 615.19
subject: 660

description: Artemisinin-based combination therapies are recommended by the World Health Organization to treat malaria, one of
the most abundant infectious diseases in the world. Recently, a novel production route, which combines the extraction
and the catalyzed chemical synthesis, has been shown to be a promising sustainable processing alternative [Triemer,
2018]. To exploit its mechanism, operational settings and limits, mathematical modeling might be beneficial when
thorough system insight is required. In a first step, we consider the catalyzed synthesis step from dihydroartemisinic
acid to artemisinin, and we show that only a subset of the parameters of the considered model is identifiable with the
available sparse data using a singular value decomposition approach. In a second step, within the framework of design
of experiments (DoE), we demonstrate the effect of additional experimental data to overcome the non-identifiability
problem of the model parameters.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research