cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
"Sorry for bugging you so much." Exploring Developers' Behavior Towards Privacy-Compliant Implementation
Creators: name: Horstmann, Stefan Albert
name: Hong, Sandy
name: Klein, David
name: Serafini, Raphael
name: Degeling, Martin
name: Johns, Martin
name: Moonsamy, Veelasha
name: Naiakshina, Alena
Publisher: name: arXiv
Year: 2025
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: While protecting user data is essential, software developers often fail to fulfill privacy requirements. However, the reasons why they struggle with privacy-compliant implementation remain unclear. Is it due to a lack of knowledge, or is it because of insufficient support? To provide foundational insights in this field, we conducted a qualitative 5-hour programming study with 30 professional software developers implementing 3 privacy-sensitive programming tasks that were designed with GDPR compliance in mind. To explore if and how developers implement privacy requirements, participants were divided into 3 groups: control, privacy prompted, and privacy expert-supported. After task completion, we conducted follow-up interviews. Alarmingly, almost all participants submitted non-GDPR-compliant solutions (79/90). In particular, none of the 3 tasks were solved privacy-compliant by all 30 participants, with the non-prompted group having the lowest number of 3 out of 30 privacy-compliant solution attempts. Privacy prompting and expert support only slightly improved participants' submissions, with 6/30 and 8/30 privacy-compliant attempts, respectively. In fact, all participants reported severe issues addressing common privacy requirements such as purpose limitation, user consent, or data minimization. Counterintuitively, although most developers exhibited minimal confidence in their solutions, they rarely sought online assistance or contacted the privacy expert, with only 4 out of 10 expert-supported participants explicitly asking for compliance confirmation. Instead, participants often relied on existing implementations and focused on implementing functionality and security first.
Latency-to-lie test without water is a valid objective method for on-farm assessment of walking ability of broilers
Creators: name: Riber, Anja B.
name: Rasmussen, Sigga
name: Wurtz, Kaitlin E.
Publisher: name: Zenodo
Year: 2024
Subjects: broiler
latency-to-lie
gait score
animal-based indicator
welfare

description: This study aimed to evaluate the validity of the Latency-To-Lie (LTL) test without using water. We tested the performance of the LTL test with and without a box to contain the birds using two broiler hybrids, Ross 308 and Rustic Gold. Latencies to lie were negatively correlated with gait scores (P<0.001), with longer standing times indicating better mobility. Within each gait score category, there was no effect of hybrid on latencies to lie for either of the tests. Using a box provided better differentiation between gait scores. The results suggest that the LTL test without water, especially with the use of a box, is a valid, objective, robust and practical method for assessing walking ability of broilers on commercial farms.
Riemann-Hypothesis-and-Shifting-Numbers-from-docx.pdf
Creators: name: Ganguly, Subhajit
Publisher: name: figshare
Year: 2017
Subjects: subject: 10301 Numerical Analysis
subject: FOS: Mathematics
subject: 10399 Numerical and Computational Mathematics not elsewhere classified

description: Posthumous publication - Due to the demise of the author prior to publishing this paper, it is being published by his near and dear ones for the dissemination of knowledge.
An angelic community: the significance of beliefs about angels in the first four centuries of Christianity
Creators: name: Ricklefs, Norman
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: There was no intrinsic reason for angels to survive in early Christian thought: Their mediatorial role was played by Christ; they were also not needed as opponents of demons and demonic magic, as Christ filled that role too. They were, thus, peripheral to mainstream Christian thought in the ante-Nicene period. We do not, therefore, find much discussion of their nature in early Christian writings, and no genuine angelologies before the fourth century. The descriptions of angels which we find are generally couched in the symbolic language of clothing imagery, which was derived from Jewish sources. Yet Christians were interested in lesser heavenly beings, and they survived in popular devotion, until in the fourth century (after Arianism and Nicaea) they became a recognized part of Christian philosophic discourse. Why then did a belief in angels survive at all in Christian thought? Christians remained interested in angels, not primarily as mediators or as demon-fighters, but as models for emulation. This emulation of angels was primarily expressed in Christian ascetic celibacy, in imitation of the angels mentioned by Christ in the synoptic Gospels (Mt 20:30, Mk 12:25, Lk 20:35-6). Angels were models of perfection, they were beings who personified the state of being that many early Christians aspired to. Implicit in this emulation of angelic behaviour is the notion that acting in a particular manner (i.e. imitating heavenly beings) meant something — that it had a result — thus it gave ordinary people some agency, some control over their spiritual state.
Self-conscious emotions among survivors of trauma
Creators: name: Lewis, Lily
Publisher: name: Lancaster University
Year: 2020

description: A literature review, empirical study and critical review were conducted into the role of self-conscious emotions (SCEs) following trauma. SCEs such as shame (evaluation of the self), guilt (evaluation of behaviour) and self-disgust (disgust directed towards the self) can cause significant distress and may be particularly high among survivors of trauma. Research has focused on individual SCEs in isolation, often using terms for the different SCEs interchangeably. Therefore, the literature review synthesised the qualitative literature on experiences of SCEs as a whole, among survivors of childhood sexual abuse. Fourteen papers were identified and synthesised using the thematic synthesis method. Three themes emerged: What the abuse means about me, (Dis)connection from others, and SCEs in the recovery journey. Within each theme was a tension between contrasting positions. The self was experienced as both powerlessly vulnerable and potently bad. Connection with others was both deeply threatening and a haven from SCEs. SCEs were both inescapable and the route to healing. Disclosure was instrumental in recovery but could be either de-shaming or re-shaming depending on the response received. The empirical paper examined the relationships between reluctance to disclose traumatic experiences, posttraumatic stress (PTS) and SCEs. Adults with experience of trauma were recruited online (n=443) and completed psychometrics measuring SCEs, reluctance to disclose and PTS. Shame and self-disgust, but not guilt, were significantly correlated with reluctance to disclose and PTS. Self-disgust but not shame moderated the relationship between reluctance to disclose and PTS. Among participants who reported sexual trauma, both shame and self-disgust moderated the relationship between reluctance to disclose and PTS. Reluctance to disclose predicted PTS at all but the highest levels of self-disgust/shame. The critical review reflected on issues of parallel process with the research, the importance of cultural context in understanding SCEs, and implications for clinical psychologists in practice.
ELT Teaching Quality and Practice in Saudi Arabia: A Case Study of the Perspectives of ESP and EGP Students, Teachers and Managers at the ELC in Umm al-Qura University
Creators: name: Melibari, Ghader
Publisher: name: UH Research Archive
Year: 2016
Subjects: ELT quality
teaching
Perspectives of ESP/EGP students, teachers and managers
Teaching and practice in KSA
ELT in UOU

description: In recent years EFL education within Saudi Arabia has come under increased scrutiny, due to government efforts to reform the broader education system within the country, and the perceived importance of English as a global language of commerce and enterprise. EFL education within Saudi Arabia suffers from a number of problems, including low standards and a tendency within the Saudi education system to rely upon prescriptive and authoritarian teaching paradigms. In addition to this, there is no cohesive national strategy for EFL teacher training and education, and little emphasis on professional development opportunities for teachers within the EFL field. This study focuses attention on EFL teacher quality within Saudi Arabia as a critical component in improving English language education across the country. The study presents a case study of Umm al-Qura University, in Mecca, Saudi Arabia, in which the perspectives of students, teachers and managers were explored in depth in order to shed light on the current mechanisms for ensuring teaching quality in EFL. Adopting a mixed-methods approach, the study engaged in an in-depth case study of the English Language Centre (ELC) at the Umm al-Qura University. A quantitative questionnaire was distributed to students within the ELC, and semi-structured interviews were undertaken with teachers and academic managers, in addition to classroom observations conducted by the researcher. The findings corroborated recent research on educational paradigms within Saudi Arabia, and highlighted a number of cultural factors that impacted upon teacher quality within the ELC. The findings of the study form the basis of a series of recommendations for improving English language teaching quality within the Kingdom of Saudi Arabia.
Vascular Calcification in Rat Cultured Smooth Muscle Cells: a Role for Nitric Oxide
Creators: name: Alsabeelah, Nimer Fehaid N
Publisher: name: UH Research Archive
Year: 2016
Subjects: Vascular calcification
Nitric oxide
Inducible nitric oxide
Vascular smooth muscle cells
Runt-related transcription factor 2

description: The underlying inflammatory storm in renal or diabetic disease may induce expression of inducible nitric oxide synthase (iNOS). Similarly, expression of iNOS or nitric oxide (NO) production in vascular smooth muscle cells (VSMCs) in a calcifying environment, may promote vascular calcification (VC) (Zaragoza et al., 2006). However, emerging data suggests that NO generated by either endothelial nitric oxide synthase (eNOS) or iNOS may protect VSMCs from VC (Kanno et al., 2008). Thus, the role of NO and its associated enzymes in the development of VC is unclear. The aim of this study was to identify whether NO produced by iNOS regulates calcification in VSMCs, and to further understanding of potential mechanisms that may mediate the actions of NO/iNOS. A significant and sustained production of NO by iNOS, which peaked at day 3 and declined thereafter was found in rat aortic smooth muscle cells (RASMCs) that were preactivated with lipopolysaccharide (LPS; 100μg ml-1) and interferon gamma (IFN-γ;100U ml-1) in the presence of calcification buffer (CB) containing calcium chloride (CaCl2; 7mM) and β-glycerophosphate (β-GP; 7mM). This was associated with formation of hydroxyapatite crystals (HA) or calcification plaques, observed via alizarin red staining (ARS) and/or fourier transform infrared (FT-IR) analysis. However, when RASMCs were incubated with the iNOS inhibitor GW274150 at 10 μM, together with LPS + IFN-γ + CB, HA crystal formation was abolished. When RASMCs were pretreated with diethylenetriamine/nitric oxide adduct (NOC 18) at either 30 or 50 μM for an hour prior to addition of CB, to generate NO; calcium levels were elevated leading to form HA crystals. However, the elevation of calcium caused by the presence of NO generated via iNOS, did not result in phosphorylation of mitogen activated protein kinases (p38 MAPK), extracellular signal-regulated kinases (Erks), and protein kinase B. Furthermore, there was a reduction of Runx2 levels (pro-calcific factor) which could be another pro-calcific factor involved in this mechanism. These findings suggest that NO may indeed play a fundamental role in calcification, enhancing mineralisation of smooth muscle cells. Furthermore, the expression of iNOS/ NO appears to be enhanced under conditions that favour calcification and these together may contribute to enhanced calcification with potential detrimental consequences in vivo.
Methods, Goals and Metaphysics in Contemporary Set Theory
Creators: name: Rittberg, Colin Jakob
Publisher: name: UH Research Archive
Year: 2016
Subjects: Philosophy of mathematical practice
set theory
Penelope Maddy
second philosophy
Ultimate-L
Methodology
Mathematical goals

description: This thesis confronts Penelope Maddy's Second Philosophical study of set theory with a philosophical analysis of a part of contemporary set-theoretic practice in order to argue for three features we should demand of our philosophical programmes to study mathematics. In chapter 1, I argue that the identification of such features is a pressing philosophical issue. Chapter 2 presents those parts of the discursive reality the set theorists are currently in which are relevant to my philosophical investigation of set-theoretic practice. In chapter 3, I present Maddy's Second Philosophical programme and her analysis of set-theoretic practice. In chapters 4 and 5, I philosophically investigate contemporary set-theoretic practice. I show that some set theorists are having a debate about the metaphysical status of their discipline{ the pluralism/non-pluralism debate{ and argue that the metaphysical views of some set theorists stand in a reciprocal relationship with the way they practice set theory. As I will show in chapter 6, these two stories are disharmonious with Maddy's Second Philosophical account of set theory. I will use this disharmony to argue for three features that our philosophical programmes to study mathematics should have: they should provide an anthropology of mathematical goals; they should account for the fact that mathematical practices can be metaphysically laden; they should provide us with the means to study contemporary mathematical practices.
title: La forma della continuità. Poetica e pratica del riuso
Creators: name: Capanna, Alessandra
name: Mele, Giampiero
Publisher: name: Sapienza University of Rome
publisherIdentifier: https://ror.org/02be6w209
publisherIdentifierScheme: ROR
Year: 2024

description: La ricerca della “forma della continuità”, tra teoria e pratica del progetto, affida alla misura il compito di conformare il nuovo sulla base dell’antico e prefigurare nuove occasioni urbane a partire da ciò che resta.
Revisiting Shop Stewards and Workplace Bargaining: Opportunities, Resources and Dynamics in Two Case Studies
Creators: name: Joyce, Simon Charles
Publisher: name: UH Research Archive
Year: 2016
Subjects: shop stewards
bargaining
workplace
union
dynamics

description: Recent accounts of workplace union representation have emphasised the exclusion of shop stewards from management decision-making processes, and have posited a shift in shop steward activity away from dealing with collective issues through bargaining, towards dealing with individual issues through casework, as part of the wider decline of union influence. This thesis challenges those accounts by showing that they utilise a problematic conceptual framework and rest upon questionable empirical foundations. An alternative framework is proposed which incorporates a clearly conceptualised definition of bargaining – something missing from previous accounts – and which develops and synthesises conceptual elements from Marxist-influenced sociologies of work, bargaining theory, and industrial relations scholarship. It is shown that efforts to influence management decision making and to restrict managerial prerogatives continue to figure prominently in shop steward activity, even though the reduction of union influence is undeniable and formal arrangements for union-management relations have been recast. Moreover, these efforts are often to some extent successful. This analysis is supported by considerable evidence from two detailed workplace studies, including an innovative use of diaries, which contribute important new insights into the activity of contemporary shop stewards. This thesis argues that the persistence of shop steward bargaining is best understood in relation to underlying dynamics of conflict and exploitation within the employment relationship under capitalism. Bargaining processes are explored in terms of changing patterns of bargaining opportunities and bargaining resources, which are linked to changing management practices. While the form and location of bargaining processes have changed, the prevalence of issues around the effort bargain and frontier of control demonstrate the continuing influence of the dynamics of workplace relations on patterns of shop steward activity. While further research is required, the theoretical and conceptual framework developed in this thesis suggests that similar processes are likely to be found elsewhere.
RA-LPEL: A Resource-Aware Light-Weight Parallel Execution Layer for Reactive Stream Processing Networks on The SCC Many-core Tiled Architecture
Creators: name: Karavadara, Nilesh
Publisher: name: UH Research Archive
Year: 2016
Subjects: RA-LPEL
HALLOC
SCC
Tiled many-core architecture
Memory management
DVFS
Reactive stream programming
Resource-aware execution layer
Power management
S-Net

description: In computing the available computing power has continuously fallen short of the demanded computing performance. As a consequence, performance improvement has been the main focus of processor design. However, due to the phenomenon called “Power Wall” it has become infeasible to build faster processors by just increasing the processor’s clock speed. One of the resulting trends in hardware design is to integrate several simple and power-efficient cores on the same chip. This design shift poses challenges of its own. In the past, with increasing clock frequency the programs became automatically faster as well without modifications. This is no longer true with many-core architectures. To achieve maximum performance the programs have to run concurrently on more than one core, which forces the general computing paradigm to become increasingly parallel to leverage maximum processing power. In this thesis, we will focus on the Reactive Stream Program (RSP). In stream processing, the system consists of computing nodes, which are connected via communication streams. These streams simplify the concurrency management on modern many-core architectures due to their implicit synchronisation. RSP is a stream processing system that implements the reactive system. The RSPs work in tandem with their environment and the load imposed by the environment may vary over time. This provides a unique opportunity to increase performance per watt. In this thesis the research contribution focuses on the design of the execution layer to run RSPs on tiled many-core architectures, using the Intel’s Single-chip Cloud Computer (SCC) processor as a concrete experimentation platform. Further, we have developed a Dynamic Voltage and Frequency Scaling (DVFS) technique for RSP deployed on many-core architectures. In contrast to many other approaches, our DVFS technique does not require the capability of controlling the power settings of individual computing elements, thus making it applicable for modern many-core architectures, with which power can be changed only for power islands. The experimental results confirm that the proposed DVFS technique can effectively improve the energy efficiency, i.e. increase the performance per watt, for RSPs.
Surviving Cardiac Arrest: Patients' Experiences of the In-Hospital Phase of Recovery
Creators: name: Spearpoint, Kenneth
Publisher: name: UH Research Archive
Year: 2017
Subjects: cardiac arrest
resuscitation
survivorship
recovery
coherence
medical gaze

description: In the UK, cardiac arrest affects approximately 30,000 people in the community annually and the incidence of cardiac arrest in hospitals is currently reported as being 1.6 events per 1000 hospital admissions. Whilst survival to hospital discharge is variable, it is likely to be no more than 10% for out-of-hospital cardiac arrest and 19% for in-hospital cardiac arrest. The survivorship literature has suggested that patients experience a range of cognitive, functional and behavioural impairments, however, contemporary outcome data from the UK has indicated that the numbers of severely brain-injured patients surviving cardiac arrest is actually low. Furthermore a review of the literature revealed that little is known about the recovery experiences of those cardiac arrest survivors who were not apparently brain-injured. This research inquiry intended to develop an informed understanding of the patients’ experiences of recovery from cardiac arrest. This included their medical and nursing care, their response and adaptation to the extra-ordinary circumstances of their survival, their worries, fears and anxieties and any other matters that that they chose to illuminate. Accordingly, an in-depth, unstructured, qualitative approach was used to interview sixteen patients during their recovery from cardiac arrest whilst they were still in-hospital patients. Grounded analysis revealed that patients experienced a three-phase recovery process that commenced with (a brief) existentialist phase followed by a calmer, more rational period. During this second phase of recovery patients appeared to develop a coping strategy that followed the salutogenic model (Antonovsky, 1996) that included phase three, the development of recovery milestones which helped them to move away from a position of illness, towards a position of health. The narrative accounts of the patients suggested that the care provision of the medical gaze during the recovery process was variable and inattentive, being that it was principally constructed around its own operational workings, rather than being centred upon the patient.
Imagine an Imageless Imagination
Creators: name: Ahlberg, Joanna
Publisher: name: UH Research Archive
Year: 2017
Subjects: imagination
propositional imagination
phenomenology
cognitive phenomenology
sensory phenomenology
sensory imagination
supposition

description: A trend in contemporary discussion pertaining to the imagination has attempted to theoretically conceptualise a type of qualia-free imagination, commonly referred to as propositional imagination. This paper argues that an act of imagination cannot be an act of imagination without both cognitive and sensory phenomenology. Both sensory and cognitive phenomenology play an important role in “fixing” the content of imaginative thoughts. Sensory phenomenology is what distinguishes imagination as an act of imagination; it is what sets imagination apart from other attitudinal mental states, such as the attitudinal mental state of supposing. Cognitive phenomenology is both proprietary and individuative to conscious thoughts, including imaginings. Each imagining takes as part of its content a distinctive kind of cognitive phenomenology which allows us to identify, differentiate and understand the particular content of a given imagining. I conclude that a type of qualia-free imagination is not, in fact, conceivable – theoretically or otherwise. Propositional imagination has phenomenology.
Solid lipid nanoparticles for delivery of Calendula officinalis extract
Creators: name: Arana, Lide
name: Salado, Clarisa
name: Vega, Sandra
name: Aizpurua-Olaizola, Oier
name: Arada, Igor De La
name: Suarez, Tatiana
name: Aresatz Usobiaga
name: Arrondo, José Luis R.
name: Alonso, Alicia
name: Go˜Ni, Félix M.
name: Alkorta, Itziar
Publisher: name: figshare
Year: 2017
Subjects: Biochemistry

description: Solid lipid nanoparticles (SLN) composed of long-chain fatty acids (palmitic acid, stearic acid or arachidicacid), Epikuron 200 (purified phosphatidylcholine), and bile salts (cholate, taurocholate or taurodeoxy-cholate) have been prepared by dilution of a microemulsion. A total of five different systems wereprepared, and characterized by photon correlation spectroscopy, transmission electron microscopy,differential scanning calorimetry, and infrared spectroscopy. The SLN formulation showing optimal prop-erties (lowest size and polydispersity index and highest zeta potential) was obtained with stearic acidand taurodeoxycholate as cosurfactant. This formulation was loaded with Calendula officinalis extract, anatural compound used on ophthalmic formulations given its anti-inflammatory, emollient, and woundrepairing activity. Calendula-loaded SLN preparations were characterized in order to determine loadingcapacity and entrapment efficiency. In vitro cytotoxicity and wound healing efficacy of Calendula-loadedSLN compared to that of a free plant extract were evaluated on a conjunctival epithelium cell line WKD.Our results suggest that this SLN formulation is a safe and solvent-free Calendula extract delivery sys-tem which could provide a controlled therapeutic alternative for reducing disease-related symptoms andimproving epithelium repair in ocular surface.
Feynman-Kac perturbation of $C^*$ quantum stochastic flows
Creators: name: Belton, Alexander C. R.
name: Wills, Stephen J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Operator Algebras (math.OA)
subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 81S25 (primary), 46L53, 46N50, 47D06, 47L25 (secondary)

description: The method of Feynman-Kac perturbation of quantum stochastic processes has a long pedigree, with the theory usually developed within the framework of processes on von Neumann algebras. In this work, the theory of operator spaces is exploited to enable a broadening of the scope to flows on $C^*$ algebras. Although the hypotheses that need to be verified in the general setting may seem numerous, we provide auxiliary results that enable this to be simplified in many of the cases which arise in practice. A wide variety of examples is provided by way of illustration.
description: 31 pages. To appear in the Indian Journal of Pure and Applied Mathematics
Quantitative Analysis of Bioactive Compounds from Aromatic Plants by Means of Dynamic Headspace Extraction and Multiple Headspace Extraction-Gas Chromatography-Mass Spectrometry
Creators: name: Omar, Jone
name: Olivares, Maitane
name: Alonso, Ibone
name: Vallejo, Asier
name: Aizpurua-Olaizola, Oier
name: Etxebarria, Nestor
Publisher: name: figshare
Year: 2017
Subjects: subject: 30199 Analytical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry

description: Seven monoterpenes in 4 aromatic plants (sage, cardamom, lavender, and rosemary) were quantified in liquidextracts and directly in solid samples by means of dynamic headspace-gas chromatography-mass spectrometry (DHS-GCMS) and multiple headspace extraction-gas chromatography-mass spectrometry (MHSE), respectively. The monoterpenes were 1st extracted by means of supercritical fluid extraction (SFE) and analyzed by an optimized DHS-GC-MS. The optimization of the dynamic extraction step and the desorption/cryo-focusing step were tackled independently by experimental design assays. The best working conditions were set at 30 °C for the incubation temperature, 5 min of incubation time, and 40 mL of purge volume for the dynamic extraction step of these bioactive molecules. The conditions of the desorption/cryo-trapping step from the Tenax TA trap were set at follows: the temperature was increased from 30 to 300 °C at 150 °C/min, although the cryo-trapping was maintained at −70 °C. In order to estimate the efficiency of the SFE process, the analysis of monoterpenes in the 4 aromatic plants was directly carried out by means of MHSE because it did not require any sample preparation. Good linearity (r2 > 0.99) and reproducibility (relative standard deviation % <12) was obtained for solid and liquid quantification approaches, in the ranges of 0.5 to 200 ng and 10 to 500 ng/mL, respectively. The developed methods were applied to analyze the concentration of 7 monoterpenes in aromatic plants obtaining concentrations in the range of 2 to 6000 ng/g and 0.25 to 110 μg/mg, respectively.
In silico scanning of structural and functional deleterious nsSNPs in Arabidopsis thaliana’s SOG1 protein, using molecular dynamic simulation approaches
Creators: name: Khan, Asif
name: Waqas, Muhammad
name: Tufail, Muhammad
name: Halim, Sobia Ahsan
name: Murad, Waheed
name: Ahmad, Syed Umair
name: Faheem, Muhammad
name: Uddin, Jalal
name: Khalid, Asaad
name: Abdalla, Ashraf N.
name: Khan, Ajmal
name: Al-Harrasi, Ahmed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Suppressor of gamma response 1 (SOG1) is a member of the NAC domain family transcription factors of the DNA damage response (DDR) signaling in the plant’s genome. SOG1 is directly involved in transcriptional response to DNA damage, cell cycle checkpoints and ATR or ATM-mediated activation of the DNA damage responses and repair functioning in programmed cell death and regulation of end reduplication. Different mutations in the SOG1 protein lead to severe diseases and, ultimately, cell death. Single nucleotide polymorphisms (SNPs) are an important type of genetic alteration that cause different diseases or programmed cell death. The current study applied different computational approaches to Arabidopsis thaliana L. SOG1 protein to identify the potential deleterious nsSNPs and monitor their impact on the structure, function and protein stability. Various bioinformatics tools were applied to analyze the retrieved 34 nsSNPs and interestingly extracted four deleterious nsSNPs, that is, ensvath13968004 (Q166L), tmp18998388 (P159L), ensvath01103049 (K199N) and tmp18998295 (Y190F). For example, homology modeling, conservation and conformational analysis of the mutant’s models were considered to scrutinize the deviations of these variants from the native SOG1 structure. All atoms molecular dynamic simulation confirmed the significance of these mutations on the protein stability, residual and structural conformation, compactness, surface conformation, dominant motion, Gibbs free energy distribution and dynamic effects. Similarly, protein–protein interaction revealed that SOG1 operates as a hub-linking cluster of various proteins, and any changes in the SOG1 might result in the disassociation of several signal transduction cascades. Communicated by Ramaswamy H. Sarma
Size Acceptance: a Discursive Analysis of Online Blogs
Creators: name: Davenport, Kate
Publisher: name: UH Research Archive
Year: 2017
Subjects: Fat Acceptance
Size Acceptance
Fat studies
Discursive Analysis
Discursive devices
Discourse
Blogging
Fatosphere

description: Traditional views on ‘overweight’ suggest that managing one’s weight is a simple balance of energy for which all individuals have the capacity and affordances to control, as long as they have the willpower to do so. This is problematic because such perspectives are drawn upon as resources for social interaction and can thus translate into deliberate negative actions and discriminatory behaviour. Despite recent evidence suggesting that ‘overweight’ is more complex than first presumed, traditional methods of weight loss remain predominant. Less culturally available perspectives do exist such as those presented by the Size Acceptance (SA) movement. SA has recently developed particular strengths because of the affordances of online blogs, including the potential for wider dissemination of less culturally available perspectives. This research explores the more and less culturally available perspectives around the fat body and how these emerge and are taken up in talk online - specifically by those who engage with SA communities. A discursive thematic analysis is used to explore how SA bloggers construct their position and identities online. Creating an awareness of how language is drawn on to construct fat ‘perspectives’ can help with becoming more resistant to hegemonic power. This research offers a unique contribution in its demonstration of how SA bloggers are positioned in such a way as to provide an alternative claim to “expertise”, which enables their views to be heard as a credible and legitimate alternative to those of more established authority-figures - such as health professionals. Furthermore, the creating of an ‘in-group’ allows for corroboration as a ‘community of experts’ and the de-legitimisation of the ‘out-group’ – that is, again, more established authority-figures, such as health professionals. This has implications for both research and clinical practice in that it can enable professionals working in physical and mental health to better understand why individuals might position themselves in ways such as SA, and what they might give up by accepting more culturally available perspectives as ‘truths’. This can help in gaining an understanding of the resistance fat people can have to professionals and change (i.e. weight loss), which might be experienced in clinical settings. Successful weight loss is deemed unlikely by much of the existing literature and failure to lose weight is associated with poorer mental health, therefore SA online might offer positive implications for mental health (regardless of weight loss) even if not for physical health. It is therefore important for professionals to be mindful of the less culturally available perspectives that exist and what online spaces offer for already-marginalised groups, before making attempts to remove or delegitimise such sites.
Mahatsak txerritzen
Creators: name: Aizpurua-Olaizola, Oier
name: Vallejo, Asier
name: Olivares, Maitane
name: Navarro, Patricia
name: Etxebarria, Nestor
name: Aresatz Usobiaga
Publisher: name: figshare
Year: 2017
Subjects: subject: 30199 Analytical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry

description: Lan honetan, optimizatu egin da bi urratseko jariakin gainkritikoaren bidezko erauzketa (SFE Supercritical Fluid Extraction), ardo hondakinetatik konposatu bioaktiboak lortzeko. Ondorioz, lortu da lehen urratsean gantz azidoak soilik eta bigarren urratsean polifenolak soilik erauztea. Polifenolek egonkortasun eskasa dute ordea. Hori dela eta, zurrusta-bibrazio bidezko mikrokapsularatzea (VNM Vibration Nozzle Microencapsulation) erabili da 150 eta 300 μm-ko zurrustekin kaltzio-alginatozko eta kaltzio-alginato-kitosanezko tamaina ezberdinetako polifenolen mikrokapsulak eratzeko. Prozesu horretan eragina duten aldagaiak optimizatu, kapsulak sortu eta haien egonkortasuna aztertu da 6 hilabetetan zehar hainbat kontserbazio-baldintzatan (4°C-ra ilunpean eta giro-tenperaturan ilunpean eta argipean). Ondorioz, ikusi da kapsulatutako polifenolen egonkortasuna baldintza guztietan kapsulatu gabeena baino askoz ere handiagoa dela.
The 1919 Railway Strike: the Government’s Response
Creators: name: Edgcombe, Joshua
Publisher: name: UH Research Archive
Year: 2018
Subjects: The 1919 Railway Strike
British Strike History
British Labor History
Industrial Relations in Interwar Britain
Railway History
Railway Union History

description: This study aims to rethink the 1919 national British rail strike from the perspective of Lloyd George’s Coalition Government. This dissertation argues that the government were willing to use all in their power to defeat the strike. Prior historians have touched upon how the government combatted the strike, but this study will give a more thorough examination of the emergency measures which were implemented. It draws from government and railway company reports on the strike which became available after 1970. There has been sparingly little research on the 1919 rail dispute since Philp Bagwell’s study in 1963. Bagwell’s classical approach to the strike will be rethought in the light of the newly accessible government and Railway Company records. A new regional approach is included, assessing the local and regional newspapers in the northern Home Counties and the north east of England.
Konposatu bioaktiboen ustiapenerako metodo analitikoen garapena/Development of analytical methods for the exploitation of bioactive compounds
Creators: name: Aizpurua-Olaizola, Oier
Publisher: name: figshare
Year: 2017
Subjects: subject: 30199 Analytical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry

description: Tesi hau bi zutabe nagusitan banatzen da. Lehenengoan ardo hondakinen balioa handitzeko metodologia bat garatu da. Lehenik, ardo hondakinetatik polifenolak eta gantz azidoak bakoitza bere aldetik erauzteko jariakin gainkritiko bidezko erauzketa (SFE) optimizatu da. Polifenolak ez dira oso egonkorrak ordea eta gorputzean bioeskuragarritasun baxua dute. Arazo hauek konpontzeko polifenolak zurrusta-bibrazio bidezko mikrokapsularatzearen (VNM) bidez enkapsulatu dira.
 Bigarren zutabean etorkizun hurbilean kannabisa sendagai bezala erabili ahal izateko 3 urrats eman dira. Alde batetik, landare ezberdinak efektu ezberdinekin lotzea ahalbidetu dezakeen landareen kannabinoideen hatz-marka osatzeko fragmentazio bikoitzeko masa-espektometriari akoplaturiko eraginkortasun handiko likido kromatografia (HPLC-MS/MS) bidezko metodo bat garatu da. Bestalde, gernuan eta plasman kannabinoideak eta euren metabolitoak kuantifikatzeko metodo bat ere garatu da, hidrolisi entzimatiko-alkalino bikoitza eta HPLC-MS/MS analisi teknika erabiliz. Azkenik, konposatu puruen eta landare mota jakinen produkzioa optimizatzeko, kemotipo ezberdineko landareen hazkuntzan zeharreko kannabinoideen eta terpenoen garapena aztertu da
Should we accept the existence of numbers as abstract objects?
Creators: name: O'Sullivan, Jacob
Publisher: name: UH Research Archive
Year: 2018
Subjects: Abstract objects
philosophy of mathematics
metaphysics
indispensability argument
Platonism
mathematical fictionalism

description: This paper argues that we should accept the existence of numbers as abstract objects. I begin by looking at the Indispensability Argument as a positive argument for the existence of mathematical objects. I look at various discussions that challenge the Indispensability Argument, most notably that we can dismiss the doctrine of Confirmational Holism by looking to an argument that we use figurative talk in science, such as idealisations. This is the argument that, like idealisations, mathematical objects are only used in scientific theories figuratively and as such their existence is not confirmed by the success of the scientific theories they are included in. In order for this objection to stand, it needs to explain what figurative uses are and so I look at Mathematical Fictionalism, which aims to explain these uses for mathematical statements. I look at Yablo’s fictionalism, as the strongest argument for explaining this, and explain how he hopes to dismiss our commitment to the existence of mathematical objects by arguing that they are ‘creatures of existential metaphor’. Finally, I raise issues with this explanation and conclude that, without further argument, the fictionalist position does not convincingly dismiss our commitment to the existence of mathematical objects and so we should accept the existence of numbers as abstract objects.
Thomas Ward Blagg and the Abbey Parish Charities Scandal c.1827-1860
Creators: name: Langsdale, Simon
Publisher: name: UH Research Archive
Year: 2018
Subjects: St Albans
Corruption
Bribery
Charity
Charities
The Great Reform Act 1832
The Municipal Corporations Act 1835
The Charity Commission

description: St Albans in the early to mid-nineteenth century suffered from endemic levels of corruption. The borough was well known for the bribery that took place at its borough elections and was the subject of three parliamentary enquiries before it was eventually disfranchised in 1852. However, historians have largely focused on the forms that the bribery took without looking below the surface to identify the underlying causes of the corruption, the networks that allowed it to function or the wider repercussions. By concentrating on the activities of the town clerk Thomas Ward Blagg, I will examine the political and other motivations for corruption and look at how Blagg’s embezzlement of several of the Abbey parish endowment charities helped fund his attempts at controlling the borough. Through this study, it will become clear that key pieces of legislation from the Age of Reform such as the Great Reform Act 1832 and The Municipal Corporations Act 1835 increased levels of corruption in the borough rather than reducing them. What followed was a ‘golden age’ of corruption, which saw competing factions trying to fill the vacuum of power that had been created by the ending of aristocratic patronage. In effect Blagg and his contemporaries were participating in a ‘New Corruption’ that would take the best part of two decades to overcome. It took the combined efforts of leading figures within the Abbey parish and the emergence of legislation from Westminster that gave the authorities unprecedented powers of intervention to bring men like Blagg under control.
Neural Networks Based Domain Adaptation in Spectroscopic Sky Surveys
Creators: name: Podsztavek, Ondřej
Publisher: name: Zenodo
Year: 2020
Subjects: domain adaptation
neural networks
deep learning
astronomical spectroscopy
astronomy

description: We present an analysis of the impact of neural-based domain adaptation in astronomical spectroscopy. Domain adaptation addresses the problem of applying prior knowledge to a new data of interest. Therefore, we selected a problem of quasar identification in the Large Sky Area Multi-Object Fiber Spectroscopic Telescope survey using labelled data from the Sloan Digital Sky Survey. We choose to experiment with four neural models for domain adaptation: Deep Domain Confusion, Deep Correlation Alignment, Domain-Adversarial Network and Deep Reconstruction-Classification Network. However, our experiments reveal that these model cannot improve classification performance in comparison to a convolutional neural network that does not consider domain adaptation. Using dimensionality reduction, statistics of the selected methods and misclassifications, we show that the domain adaptation methods are not robust enough to be applied to the complex and dirty astronomical data.
Supplementary figures from Collective foraging in spatially complex nutritional environments
Creators: name: Lihoreau, Mathieu
name: Charleston, Michael A.
name: Senior, Alistair M.
name: Clissold, Fiona J.
name: Raubenheimer, David
name: Simpson, Stephen J.
name: Buhl, Jerome
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour
subject: Computational Biology

description: Figures S1-S3
Adab Menuntut Ilmu sebagai Landasan Profesionalisme dan Empati dalam Dunia Kesehatan (1).pdf
Creators: name: Anisa, Anisa Dwi Istiqomah
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 300103
subject: Agricultural molecular engineering of nucleic acids and proteins

description: Penelitian ini bertujuan untuk mengkaji konsep adab menuntut ilmu dalam perspektif Islam serta menganalisis kontribusinya dalam membentuk profesionalisme dan empati tenaga kesehatan. Metode yang digunakan adalah studi pustaka, dengan sumber data dari referensi primer seperti Al-Qur'an, hadis, serta kitab klasik seperti Ta'limul Muta'allim, dan literatur kesehatan terkait etika medis dan pelayanan berbasis empati. Hasil penelitian menunjukkan bahwa nilai-nilai adab seperti niat yang ikhlas, tawadhu’, kesabaran, dan penghormatan terhadap guru berperan penting dalam membentuk karakter tenaga kesehatan yang disiplin, berintegritas, dan manusiawi. Implementasi nilai-nilai adab tersebut terbukti memperkuat profesionalisme tenaga kesehatan, serta meningkatkan kemampuan empati dalam memahami kondisi pasien, yang berdampak positif terhadap kualitas pelayanan kesehatan. Kesimpulannya, adab menuntut ilmu bukan hanya kewajiban spiritual, tetapi merupakan fondasi utama dalam membangun tenaga kesehatan yang kompeten secara ilmiah, beretika, dan mampu memberikan pelayanan berbasis nilai-nilai kemanusiaan. Integrasi nilai-nilai adab dalam kurikulum pendidikan kesehatan sangat diperlukan untuk mewujudkan pelayanan medis yang lebih bermartabat, berkeadilan, dan membawa keberkahan.
An Anatomy of a 'Disorderly' Neighbourhood: Rosemary Lane and Rag Fair c.1690-1765
Creators: name: Turner, Janice
Publisher: name: University of Hertfordshire
Year: 2015
Subjects: Disorderly
Makeshift
Rag Fair
Rosemary Lane
Thief-takers

description: This thesis focuses on the experiences of the ‘disorderly’ neighbourhood of Rosemary Lane and Rag Fair in the eastern suburbs of London in c.1690 to 1765. Rosemary Lane and Rag Fair possessed one of the most powerfully articulated reputations for disorder of any London street. In the imagination of both novelists and social investigators it was thought to be squalid, dangerous, dirty - the stereotypical ‘den of iniquity’. Using a wide range of material including parish records, Middlesex session papers, eighteenth century newspapers, and digital sources such as the Old Bailey On-Line and London Lives this thesis will explore the streets and alleyways of Rag Fair. It will go beyond the simple perception of a disorderly neighbourhood, to describe the individual communities and forces which created that disorder. It will show that the poor of Rosemary Lane, generally, did not see themselves as a problem waiting to be solved, they were resourceful and they had their own way of surviving - they were active players in a changing City that was shaking off its medieval roots and embracing the modern. By looking in detail at this community; at its structures and divisions, and at its power relations, its self-identity will be revealed.