cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Revealing the cholinergic inhibition mechanism of Alzheimer’s by galantamine: a metadynamics simulation study
Creators: name: Ghosh, Shibaji
name: Jana, Kalyanashis
name: Wakchaure, Padmaja D.
name: Ganguly, Bishwajit
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Galantamine is one of the approved drugs based on the cholinergic hypothesis for the symptomatic treatment of mild to moderate Alzheimer’s disease (AD). The etiology of AD is not fully known; however, the reported cholinergic hypothesis suggests the inadequate synthesis of the neurotransmitter acetylcholine (ACh) is responsible for this disease. The crystal structure of galantamine bound human acetylcholinesterase (hAChE) has been reported; however, the inhibition mechanism of hAChE by galantamine is not well understood. A Well-tempered metadynamics (WTMtD) simulation study has been performed with the crystal structure of galantamine bound hAChE. The reported mechanism for the degradation of ACh is suggested through a proton transfer process from a carboxylic group of Glu334 to the hydroxyl group of Ser203, which attacks ACh for the degradation to acetic acid and choline. Such proton transfer process is lowered in the presence of galantamine due to the separation of catalytic triad inside the gorge of AChE as observed with WTMtD. A docking study has been performed to examine the ACh's binding with the catalytic triad of galantamine bound hAChE. The docking results reveal that the approach of ACh to the catalytic triad is interrupted due to the galantamine's presence in the gorge of the enzyme. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 24559.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.10.1974, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Crucero ARA General Belgrano in memóriam. Linajes político-navales en las memorias de Malvinas
Creators: name: Guber, Rosana
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Guerra de Malvinas/Falklands; Fuerzas Armadas; Memoria Social; Argentina; Siglo XX; War of the Falklands/Malvinas; Armed Forces; Social memory; Argentine; 20th Century

description: Se expone aquí cómo la marinería de la Armada Argentina construyó la memoria del conflicto anglo-argentino por las islas Malvinas (Falklands) en la primera posguerra. Al conmemorarse el décimo aniversario del hundimiento del crucero General Belgrano  (2 de mayo de 1982), el mayor desastre argentino en la contienda bélica se articula con dos hitos de la política interna argentina, poniendo de manifiesto los fundamentos nacionales de las memorias de este conflicto internacional.
Abstract
This paper depicts the foundations of the early postwar Argentine naval memories of the Anglo-Argentine Malvinas/Falklands War. During the tenth anniversary of the sinking of the Belgrano Cruiser (May 2nd 1982), the greatest Argentine disaster is tied to two events in Argentine politics in which the Navy was involved. Such an articulation deploys the national bases underlying the memories of this international war.
description: IBEROAMERICANA, Vol. 8, Núm. 30 (2008)
Imuno-estimulantes na prevenção de infeções respiratórias em crianças
Creators: name: Gil, Joana
name: Costa, João
name: Vaz Carneiro, António
name: M Fernandes, Ricardo
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Sonnenfleckenzeichnung Nr. 24493.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.07.1974, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Ikaros Chatzimanolis & Brunke 2021, gen. nov.
Creators: name: Chatzimanolis, Stylianos
name: Brunke, Adam J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Ikaros

description: Key to the species of Ikaros gen. nov.
1. Arch-like carina present on terga 3–5; stark polygon-shaped microsculpture present on the dorsal surface of the head and thorax; long (macrosetae at least twice as long as antennomeres) crown-like macrosetae on antennomeres ................................................................. I. polygonos gen. et sp. nov.
– Arch-like carina absent on terga 3–5; without stark polygon-shaped microsculpture on the dorsal surface of the head and thorax; crown-like macrosetae on antennomeres not as long, shorter than antennomeres .................................................................................................................................... 2
2. Disc of pronotum with only the few punctures of the dorsal row .............. I. apteros gen. et sp. nov.
– Disc of pronotum with multiple rows of punctures ................................... I. paramo gen. et sp. nov.
description: Published as part of Chatzimanolis, Stylianos & Brunke, Adam J., 2021, A new apterous rove beetle genus (Coleoptera: Staphylinidae) from the Northern Andes with an assessment of its phylogenetic position, pp. 67-82 in European Journal of Taxonomy 744 on page 78, DOI: 10.5852/ejt.2021.744.1303, http://zenodo.org/record/4673914
Computational approach to explore the inhibitory potential of biologically derived compounds against Spodoptera litura vitellogenin receptor (VgR) using structure based virtual screening and molecular dynamics
Creators: name: Aathmanathan, Veeranarayanan Surya
name: Arumugam, Velusamy
name: Krishnan, Muthukalingan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: In the everlasting combat against the pests of agricultural importance, it is essential to come up with a novel strategy for pest control. This can be achieved through understanding the insect pest at cellular and molecular levels. Vitellogenin (Vg) and vitellogenin receptor (VgR) are essential for successful reproduction in insect. The N-terminal Ligand Binding Domain (LBD) of VgR is responsible for the transportation of vital protein (Vg) to the developing oocyte through receptor mediated endocytosis pathway. This can be implemented to various predicaments and betterments for exploitation in pest management, in a target specific and eco-friendly manner. For this, natural metabolites isolated from various biological sources were used as ligand. The purpose of this study was to analyze the inhibitory potential of 14 biologically derived compounds against N-terminal (Ligand Binding Repeats) LBRs of S. litura by computational docking. 3 D structure of LBRs of S. litura was generated by Raptor X software and the structure was refined and validated. The validated structure was docked using autodock vina. Docking results revealed that spinosyn A and milbemycin A4 have inhibitory activity against VgR. Molecular dynamics (MD) simulation confirms the stable binding of the ligand. From the above results, spinosyn A and milbemycin A4 may be exploited for the pest management. Communicated by Ramaswamy H. Sarma
Dual inhibition of SARS-CoV-2 spike and main protease through a repurposed drug, rutin
Creators: name: Kumari, Anchala
name: Rajput, Vikrant Singh
name: Nagpal, Priya
name: Kukrety, Himanshi
name: Grover, Sonam
name: Grover, Abhinav
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The global health emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to alarming numbers of fatalities across the world. So far the researchers worldwide have not been able to discover a breakthrough in the form of a potent drug or an effective vaccine. Therefore, it is imperative to discover drugs to curb the ongoing menace. In silico approaches using FDA approved drugs can expedite the drug discovery process by providing leads that can be pursued. In this report, two drug targets, namely the spike protein and main protease, belonging to structural and non-structural class of proteins respectively, were utilized to carry out drug repurposing based screening. The exposed nature of the spike protein on the viral surface along with its instrumental role in host infection and the involvement of main protease in processing of polyproteins along with no human homologue make these proteins attractive drug targets. Interestingly, the screening identified a common high efficiency binding molecule named rutin. Further, molecular dynamics simulations in explicit solvent affirmed the stable and sturdy binding of rutin with these proteins. The decreased Rg value (4 nm for spike-rutin and 2.23 nm for main protease-rutin) and stagnant SASA analysis (485 nm/S2/N in spike-rutin and 152 nm/S2/N in main protease-rutin) for protein surface and its orientation in the exposed and buried regions suggests a strong binding interaction of the drug. Further, cluster analysis and secondary structure analysis of complex trajectories validated the conformational changes due to binding of rutin. Communicated by Ramaswamy H. Sarma
Additional file 1 of Climate change and heat stress resilient outdoor workers: findings from systematic literature review
Creators: name: Habibi, Peymaneh
name: Razmjouei, Jaleh
name: Moradi, Amirhossein
name: Mahdavi, Farank
name: Fallah-Aliabadi, Saeed
name: Heydari, Ahad
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Sonnenfleckenzeichnung Nr. 24573.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.11.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Una reflexión en torno de la caracterización de las cortes constitucionales
Creators: name: Ansolabehere, Karina
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Cortes Constitucionales; Política; Justicia; Poder

description: ¿Cómo puede definirse el poder de una corte suprema/corte constitucional en una democracia? Éste es el interrogante en el que se enmarca la presente reflexión. El propósito de este trabajo es el desarrollo de una propuesta analítica para caracterizar a las supremas cortes de justicia/tribunales constitucionales, a partir de su sus facultades de control del poder político (poder) y de sus contrapesos (límites a su poder).
description: IBEROAMERICANA, Vol. 8, Núm. 31 (2008)
Sonnenfleckenzeichnung Nr. 24528.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.09.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
La administración de las políticas de justicia en América Latina: nuevos horizontes de reforma
Creators: name: Linares, Sebastián
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Justicia; Administración; América Latina; Reforma; Siglos XX-XXI

description: Los países de América Latina, desde principios de la década de 1990, han implementado numerosas reformas judiciales. Las mismas estuvieron guiadas por el propósito de mejorar la eficiencia de los procesos judiciales, aumentar el acceso a la justicia y promover la independencia judicial. Sin embargo, todavía persisten serios problemas de eficiencia, acceso e independencia. Una de las áreas más problemática es la de la administración de las políticas públicas de justicia.
description: IBEROAMERICANA, Vol. 8, Núm. 31 (2008)
Computational-aided design: minimal peptide sequence to block dengue virus transmission into cells
Creators: name: Arumugam, Aathe Cangaree
name: Agharbaoui, Fatima Ezzahra
name: Khazali, Ahmad Suhail
name: Yusof, Rohana
name: Rahman, Noorsaadah Abd
name: Al Hadi Ahmad Fuaad, Abdullah
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Dengue virus (DV) infection is one of the main public health concerns, affecting approximately 390 million people worldwide, as reported by the World Health Organization. Yet, there is no antiviral treatment for DV infection. Therefore, the development of potent and nontoxic anti-DV, as a complement for the existing treatment strategies, is urgently needed. Herein, we investigate a series of small peptides inhibitors of DV antiviral activity targeting the entry process as the promising strategy to block DV infection. The peptides were designed based on our previously reported peptide sequence, DN58opt (TWWCFYFCRRHHPFWFFYRHN), to identify minimal effective inhibitory sequence through molecular docking and dynamics studies. The in silico designed peptides were synthesized using conventional Fmoc solid-phase peptide synthesis chemistry, purified by RP-HPLC and characterized using LCMS. Later, they were screened for their antiviral activity. One of the peptides, AC 001, was able to reduce about 40% of DV plaque formation. This observation correlates well with the molecular mechanics-Poisson–Boltzmann surface area (MM-PBSA) analysis – AC 001 showed the most favorable binding affinity through 60 ns simulations. Pairwise residue decomposition analysis has revealed four key residues that contributed to the binding of these peptides into the DV2 E protein pocket. This work identifies the minimal peptide sequence required to inhibit DV replication and explains the behavior observed on an atomic level using computational study. Communicated by Ramaswamy H. Sarma
Definição do prognóstico neurológico da prematuridade – estado da arte
Creators: name: Graça, André M
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: Num tempo em que a maioria dos grandes pré-termo sobrevive, a definição do prognóstico neurológico tornou-se crucial neste grupo de doentes. Apesar da intensa investigação na área da Neurologia Neonatal, designadamente nas áreas da monitorização contínua da actividade cerebral e nas técnicas avançadas de ressonância magnética, continua a ser na avaliação clínica, e, sobretudo, na ecografia cerebral, que se baseia a definição do prognóstico neurológico individual para cada grande prematuro. Torna-se, assim, para os próximos anos, crucial investir na formação adequada dos neonatologistas em ecografia cerebral, assim como na realização de ecografias frequentes, de acordo com os protocolos internacionais. Com estes cuidados será possível antecipar a maioria dos casos com prognóstico desfavorável. A realização de ressonância magnética a todos os grandes pré-termo, independentemente do seu grau de imaturidade, não se justifica na medida em que esta técnica ainda não fornece informação inequivocamente superior à ecografia, pondendo inclusivamente fornecer dados de dificil interpretação e com correlação prognóstica duvidosa, contribuindo para um aumento dos níveis de ansiedade parental.
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Poder Judicial, transparencia y participación ciudadana: reformas recientes en Argentina
Creators: name: Herrero, Álvaro
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Poder Judicial; Sociedad Civil; Transparencia; Democracia; América Latina

description: Desde hace más de una década se discute en torno a los problemas de imagen y legitimidad que afectan a gran parte de los poderes judiciales de América Latina. En muchos países de la región –y esto no resulta novedoso– las encuestas indican de manera sostenida que los niveles de confianza de la ciudadanía en el sistema de justicia son preocupantemente bajos (ver informes de Latinobarómetro). Las causas detrás de este diagnóstico son múltiples: falta de independencia de los jueces, obstáculos para el acceso a la justicia, ineficacia del poder judicial para hacer frente a la inseguridad ciudadana y casos de corrupción judicial, entre otras.
description: IBEROAMERICANA, Vol. 8, Núm. 31 (2008)
Sonnenfleckenzeichnung Nr. 24535.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.09.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Pharta Thorell 1891
Creators: name: Benjamin, Suresh P.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Thomisidae
Pharta

description: Genus Pharta Thorell, 1891
Remarks. Pharta is described and diagnosed in Benjamin (2011).
description: Published as part of Benjamin, Suresh P., 2014, Two new species of Pharta Thorell, 1891 with the description of Ibana senagang gen. et sp. nov. (Araneae: Thomisidae), pp. 177-182 in Zootaxa 3894 (1) on page 177, DOI: 10.11646/zootaxa.3894.1.15, http://zenodo.org/record/226402
La justicia electoral y los recuentos de votos en México
Creators: name: Medina Torres, Luis Eduardo
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Justicia Electoral; Votos; México; Política

description: La justicia electoral de México es la instancia que resuelve las demandas presentadas por los partidos políticos con motivo de los resultados de una votación. Este artículo analiza sus funciones a raíz de las elecciones presidenciales de 2006.
description: IBEROAMERICANA, Vol. 8, Núm. 31 (2008)
Sonnenfleckenzeichnung Nr. 24586.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.12.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Epilepsia – mais do que os olhos vêem
Creators: name: Carvalheiro, Irina
name: Faleiro, Joana
name: Monteiro, José Paulo
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: Criança, sexo feminino, sete anos, referenciada aos cinco anos de idade por crises parciais complexas de predomínio nocturno, com dois meses de evolução. Antecedentes pessoais de dificuldades na linguagem e de coordenação motora desde os dois anos e história familiar de epilepsia na linha materna. A observação e o exame neurológico não revelaram alterações. O electroencefalograma mostrou atividade paroxística focal temporal direita e a ressonância crânio-encefálica revelou bandas bilaterais de substância cinzenta interpostas na substância branca entre o córtex e os ventrículos laterais (figuras 1 e 2) compatível com heteropia subcortical em banda. Por apresentar gradiente anteroposterior da heterotopia foi pedido estudo molecular do gene DCX e encontrada a mutação c.814C>T em heterozigotia no exão 5. A avaliação neuropsicológica (WPPI-R realizada aos 6 anos) revelou dificuldades globais nas provas verbais e nas de realização associadas a uma imaturidade emocional. Atualmente controlada com carbamazepina e zonizamida. A mãe, apesar da identificação da mesma mutação, é assintomática e a ressonância não tem lesões estruturais. Apesar da epilepsia relativamente fácil de controlar e da ausência de dismorfias ou sinais focais no exame neurológico, a imagem revelou uma extensa malformação cortical tendo o diagnóstico sido imagiológico e molecular. Palavras-chave: Heterotopia subcortical em banda, Epilepsia, gene DCX
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Los sentidos y las ruinas
Creators: name: Masiello, Francine
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Ruina; Identidad; Nación; Argentina; Siglo XX

description: Camino a Cafayate, al norte de Tucumán, la ciudadela de los indios quilmes me permite el descanso y la reflexión. Escalando lo que en otra época fue la fortaleza de una cultura poderosa, estudio el horizonte, admiro las alturas, intento reconstruir la vida de los indígenas tal como hubiera sido en una época muy lejana. Sin embargo, estos pensamientos no son libres, ni son míos; más bien, el libro de turismo me dice cómo tengo que mirar, me cuenta la historia de la cultura quilmes para que no me quede ninguna sorpresa. Los quilmes, la civilización más grande de la Argentina antes de la llegada de los españoles, primero resistían los avances del imperio incaico y después, durante 130 años, se oponían a los conquistadores. Sabemos por los guías de turismo que los españoles arrancaron a los últimos sobrevivientes a pie a Buenos Aires. La gran mayoría pereció en el camino. También sabemos que las ruinas de los quilmes fueron rehabilitadas durante la última dictadura militar. Imposible, entonces, no captar la ironía del gesto de los militares al recordar a los indígenas desaparecidos mientras seguían desapareciendo al pueblo argentino durante la década de los años setenta.
description: IBEROAMERICANA, Vol. 8, Núm. 30 (2008)
Pharta sudmannorum Benjamin, 2014, sp. nov.
Creators: name: Benjamin, Suresh P.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Thomisidae
Pharta
Pharta sudmannorum

description: Pharta sudmannorum sp. nov.
Figs 1A–C, 1 E, F, 2A–D
Type material: Holotype ♂ from MALAYSIA: Borneo: West Sabah, 6º 06' N 116º 50' E, Mt. Kinabalu national park, Sorinsim, 15 year old adjacent secondary forest, 500–700 m, Loc 50, canopy fogging Vinex pinnata, leg. A. Floren, 12 March 1997; badly preserved (RMNH.ARA.15918).
Other material examined. MALAYSIA: Borneo: 1 female, West coast of Sabah, 6º 02' N 116º 42' E, Poring Hot Springs, Canopy walk, leg. C. L. Deeleman and P. Zaborowski, 0 1 April 1998 (RMNH.ARA.15922). MALAYSIA: Borneo: 1 ♀, West Sabah, 6º 02' N 116º 42' E, Mt. Kinabalu national park, Poring Hot Springs, primary forest, 500–700 m, canopy fogging Aporusa sp., leg. A. Floren, 19–26 March 1996, loc 14 (19 February 1996), epigynum missing (RMNH.ARA.15915). Same data, 1 ♀ (RMNH.ARA.15911).
Etymology. This species is named in honor Heinrich and Marga Sudmann of Bonn, in appreciation of their assistance to me and my family during our visits to Bonn.
Diagnosis. Males of P. sudmannorum sp. nov. can be distinguished from male congeners by the curved conductor with a pointed tip and the presence of two apical tibial apophysis; females by the presences of funnelshaped copulatory ducts and oval spermathecae. Further, in P. sudmannorum sp. nov. and all known female congeners the epigynum is roughly the shape of an ‘8’, with the top half containing the funnel-shaped copulatory ducts and the bottom half the spermathecae. In P. sudmannorum sp. nov. the bottom half is larger than the top half (Figs 1 E, 2D).
Description. Male (holotype): Total length: 2.5; prosoma length: 1.3, width: 1.1. Leg I: femur 1.4, patella 0.4, tibia 1.2, metatarsus 0.9, tarsus 0.5. Coloration and markings as in Fig. 1A. Light to dark yellow, possibly greenish in life. Prosoma and sternum uniformly covered with sub erected, brownish, strong setae (not movable), legs covered with partially paired, moveable spines. (Fig. 1A). ALE> PLE> PME> AME. AER, PER recurved, eyes on brown colored, converging mounds. Palp with a curved conductor with a pointed tip and two apical tibial apophysis (Figs 2A, 2B).
Female: Total length: 3.8; prosoma length: 1.8, width: 2.0. Leg I: femur 2.0, patella 0.8, tibia 2.0, metatarsus 1.4, tarsus 0.8. Leg formula 2143. General description as in male. Coloration and markings as in Figs 1B, C. Epigynum and vulva with funnel-shaped copulatory ducts and oval spermathecae as in Figs 1 E, 1F, 2C, 2D.
Distribution. Known only from the type locality, Mt. Kinabalu National Park.
Remarks. Males and females are grouped based on appearance and should be reassessed when more material is available.
description: Published as part of Benjamin, Suresh P., 2014, Two new species of Pharta Thorell, 1891 with the description of Ibana senagang gen. et sp. nov. (Araneae: Thomisidae), pp. 177-182 in Zootaxa 3894 (1) on pages 179-180, DOI: 10.11646/zootaxa.3894.1.15, http://zenodo.org/record/226402
Novel P,C-orthopalladated complexes containing histidine and phenylalanine amino acids: synthesis, DNA and BSA interactions, in vitro antitumoral activity and molecular docking approach
Creators: name: Hashemi, Sara
name: Karami, Kazem
name: Dehkordi, Zeinab Saberi
name: Momtazi-Borojeni, Amir Abbas
name: Esmaeili, Seyed Alireza
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Novel [Pd(o-CH2C6H4P(o-tolyl)2)(histidine)] (1) and [Pd(o-CH2C6H4P(o tolyl)2)(phenylalanine)] (2) P,C-orthopalladated complexes have been prepared and characterized by elemental analysis, IR and NMR spectroscopy. To study the stability of the compounds in biological media, the complexes were incubated in Tris buffer during 10 days. The absorbance of the compounds remained constant, which confirmed the stability of the complexes in biological media. UV-Vis absorption spectrophotometry, fluorescence spectroscopy and viscosity studies were used to investigate the binding of the complexes with native calf thymus DNA (CT-DNA). These methods along with competitive binding of methylene blue (MB) DNA show that the complexes interact with DNA via groove mode. The UV-Vis absorption spectrophotometry of BSA with complexes has shown an α-helix perturbation induced by a particular interaction between the metal complexes and BSA. In addition, the fluorescence quenching mechanism of BSA with the complexes is a static process, according to the fluorescence spectrometry of bovine serum albumin (BSA). The experimental results of site competitive replacement with specific site markers are clear indications that the complexes bind to site I of BSA. Furthermore, both complexes showed significant selective cytotoxic activity against melanoma B16F0 and colon carcinoma C26 cancer cells as well as normal fibroblast NIH cell line. Ultimately, the binding of Pd(II) complexes to DNA and BSA was verified by molecular docking experiment. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 24585.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.12.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.06.1974, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Dengue em Portugal – Experiência da Região Autónoma da Madeira
Creators: name: Castro, Leonor
name: Marçal, Filipa
name: Gonçalves, Jenny
name: Oliveira, Joana
name: Miranda, Victor
name: Freitas, Cristina
name: Barros, Andreia
name: Freitas, Pedro
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: Introdução: O dengue é uma doença viral, autolimitada, transmitida pelo mosquito do género Aedes. A introdução do vector de transmissão na ilha da Madeira levantou a ameaça de uma epidemia. Apesar da implementação das medidas de controlo do vector,oito anos após a sua detecção verificou-se o primeiro surto de dengue na região. Este estudo tem como objectivo a caracterização dos casos de dengue em idade pediátrica no primeiro surto de dengue desta região. Metodologia: Estudo retrospectivo, observacional e descritivo. Foram incluídas crianças e adolescentes dos 0 aos 14 anos com diagnóstico de dengue confirmado laboratorialmente. Caracterização de variáveis demográficas, clínicas e analíticas, com posterior análise e tratamento estatístico. Resultados: Foram confirmados 182 casos laboratorialmente, verificando-se predomínio do sexo masculino e idade média de 9,6 anos. A taxa de incidência foi de 41,4/10.000 habitantes, com pico de incidência em Novembro 2012. Os sintomas de apresentação mais frequentes foram a febre (98,3%), cefaleias (75,2%), mialgias (66,5%) e exantema (51,6%), sendo que as manifestações hemorrágicas surgiram em 9,9% dos casos. A taxa de internamento foi de 15,9%, com duração média de 3,8 dias, não sendo registados óbitos.Foi identificado somente o serotipo DEN-1. Discussão: A elevada densidade do vector associada à presença de hospedeiros susceptíveis poderá ter originado a explosão do surto, após a introdução do vírus na região. Sendo a imunidade serotipo-específica, a presença de um novo serotipo poderia ter consequências devastadoras, pelo que dada a possibilidade de um novo surto, devem ser mantidas as medidas de controlo entomológico e de protecção individual.
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Cianose Central Neonatal: nem sempre cardíaca, nem sempre pulmonar
Creators: name: Spinola, Ana Isabel Franco
name: Guilherme, Raquel Ferreira
name: Bento, Celeste
name: Relvas, Luís
name: Oliveira, Ana Catarina
name: Neves, José Farela
name: Ribeiro, Maria Letícia
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: A cianose congénita está frequentemente associada a patologias que diminuem a oxigenação da hemoglobina (Hb) ou sua capacidade para libertar o oxigénio (O2). Descritos 3 casos de cianose neonatal que apresentavam baixa saturação tecidular de O2, com fraca resposta à oxigenoterapia e níveis de MetaHb elevados. A cianose diminuiu gradualmente, concomitantemente com a redução dos níveis de MetaHb, sugestivo da presença de uma variante M de Hb resultante de uma mutação nas cadeias globínicas gama. A sequenciação do gene HBG2 identificou a mutação c.85 C>A em heterozigotia. Esta mutação, não descrita na literatura, leva à substituição de um aminoácido valina por metionina, com formação de uma variante M da Hb, designada Hb F-M Viseu dada a origem dos doentes.
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Arguedasmachine: Modernity and Affect in the Andes
Creators: name: Beasley-Murray, Jon
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: José María Arguedas; Novel; Peruvian Literature; 20th Century

description: Peruvian writer José María Arguedas’s final book, an unfinished and posthumously published novel entitled El zorro de arriba y el zorro de abajo, is set in the coastal boomtown of Chimbote during the late 1960s. Rapid industrialization has led to the town being dominated by fish-processing factories belching out smoke, and surrounded by slums in which thousands of recent immigrants from the Andes eke out a living at the margins of this intense capitalist exploitation. The novel’s main concern is with these margins, with the slums or barriadas in which all of Peru’s cultures and languages are thrown together in chaos and misery, if also in vital intercommunication and restless striving. But at the center of the novel is a strange scene of epiphany that takes place at the heart of the industrial enterprise.
description: IBEROAMERICANA, Vol. 8, Núm. 30 (2008)
Tiroidite auto-imune em adolescente - um caso com atingimento multiorgânico
Creators: name: Póvoas, Marta
name: Mateus, Ana
name: Silva, Lia
name: Joaquim, M. Isabel
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: A tiroidite auto-imune é a causa mais frequente de hipotiroidismo primário adquirido na criança. A sintomatologia inicial pode ser subtil, dificultando o diagnóstico e tratamento atempados, essenciais na prevenção de complicações. Apresenta-se um caso raro de tiroidite auto-imune com atingimento multiorgânico numa adolescente de 12 anos com baixa estatura.
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Una crítica acéfala para la modernidad latinoamericana
Creators: name: Antelo, Raúl
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Modernismo; América Latina; Crítica

description: Adorno (1971) consideraba que el modernismo es tan sólo un aspecto, quizás incluso irrelevante, del proyecto moderno y alertaba, a su modo, contra la tentación de sacrificar la parte para salvar el todo, aunque era consciente, sin embargo, del riesgo que comportaba una excesiva o absorbente identificación de la parte con el todo. Criticar el modernismo no necesariamente debe confundirse con negarle validez a la modernidad tout court. Pero, alertados acerca de ese riesgo, se debe, sin duda, emprender una crítica al modernismo porque, no hacerlo, puede abrirle el camino, como lo está abriendo, al más torpe neoconservadurismo –Alain Badiou (2007), con inocultable galocentrismo, nos diría, más bien, al petainismo– de una política que postula sin tregua un retorno acrítico y nostálgico al pasado.
description: IBEROAMERICANA, Vol. 8, Núm. 30 (2008)
Diabetes relacionada com Fibrose Quística: o valor da monitorização contínua da glicose versus prova de tolerância à glicose oral
Creators: name: Santalha, Marta
name: Barbosa, Telma
name: Amaral, Brígida
name: Borges, Teresa
name: Ribeiro, Luís
name: Oliveira, Maria João
name: Cardoso, Helena
name: Senra, Vírgilio
name: Rocha, Herculano
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: A diabetes é uma importante complicação da fibrose quística (FQ) e se não tratada, condiciona deterioração do estado nutricional e pulmonar. Objetivo e métodos: Avaliar o perfil de glicose dos doentes com FQ seguidos num centro pediátrico terciário, através do sistema de monitorização contínua da glicose (MCG); comparar com os resultados obtidos na prova de tolerância à glicose oral (PTGO) e doseamento da HbA1c. Critérios de exclusão: idade inferior a dez anos, terapêutica imunossupressora, corticoterapia sistémica, transplantados ou com o diagnóstico já estabelecido de diabetes. Resultados: Foram incluídos nove doentes, cinco do sexo masculino, com idade média de 14,8 anos. A mutação ?F508 em homozigotia estava presente em três casos. A PTGO foi normal em oito casos, sendo que num caso revelou anomalia da glicemia em jejum. O valor médio da HbA1c foi de5,4 + 0,3% [5,1-5,9%]. Na MCG o valor médio global da glicose, da glicose mínima e máxima foi de 102,7+ 8,2 mg/dl, 63,2+ 13,7 mg/dl e 164,5+ 27 mg/dl, respetivamente. Verificaram-se picos de glicose superiores a 140 mg/dl em sete doentes, um dos quais superior a 200 mg/dl. Em cinco doentes ocorreram hipoglicemias assintomáticas. Conclusão: A maioria dos doentes obteve um perfil de glicose durante a MCG com valores inferiores a 200mg/dl. Contudo, observaram-se valores patológicos em mais de metade dos casos. As hipoglicemias assintomáticas encontradas no estudo podem refletir uma secreção inapropriada de insulina. Os autores consideram que a MCG permite um melhor diagnóstico de distúrbios da glicose nos doentes com FQ, comparativamente à PTGO.
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)
Sonnenfleckenzeichnung Nr. 24547.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.09.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Pharta koponeni Benjamin, 2014, sp. nov.
Creators: name: Benjamin, Suresh P.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Thomisidae
Pharta
Pharta koponeni

description: Pharta koponeni sp. nov.
Figs 1 D, 2E, 2F
Type material: Holotype ♂ from THAILAND: Kanchanaburi Province: Erawan National Park, leg. C. L.
Deeleman & P. R. Deeleman, 16 October 1987, evergreen forest, sweeping (RMNH.ARA.15912). Etymology. This species is named in honor of my colleague Seppo Koponen of Turku, Finland. Diagnosis. Male of P. koponeni sp. nov. can be distinguished from male congeners by the longer, hammer-
shaped conductor. The conductor is shorter and sharply curved in P. sudmannorum sp. nov. Description. Male. Total length: 2.2; prosoma length: 1.1, width: 1.1. Leg I: femur 1.4, patella 0.5, tibia 1.2,
metatarsus 0.9, tarsus 0.5. Leg formula 1243. Coloration and markings as in Fig. 1 D. Light yellow, probably
greenish in life. Opisthosoma roundish. Prosoma uniformly covered with short, brownish spines (Fig. 1A). ALE>
PLE> PME> AME. AER, PER recurved, eyes on brown colored, converging mounds.
Palp with a hammer-shaped conductor as in Figs (2E, 2F).
Female: unknown
Distribution. Known only from the type locality.
description: Published as part of Benjamin, Suresh P., 2014, Two new species of Pharta Thorell, 1891 with the description of Ibana senagang gen. et sp. nov. (Araneae: Thomisidae), pp. 177-182 in Zootaxa 3894 (1) on page 180, DOI: 10.11646/zootaxa.3894.1.15, http://zenodo.org/record/226402
Pensar nuestra globalizada modernidad. Desencantos de la socialidad y reencantamientos de la identidad
Creators: name: Martín-Barbero, Jesús
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Identidad; Izquierdas; Desengaño; Política; Modernidad; América Latina

description: Norbert Lechner (1995) analiza el desencanto de las izquierdas, que se expresa en el “enfriamiento de la política”, como el surgimiento de una nueva sensibilidad marcada por el abandono de las totalizaciones ideológicas, la desacralización de los principios políticos y la resignificación de la utopía en términos de negociación como forma de construcción colectiva del orden. Lo que implica la predominancia de la dimensión contractual y el predominio, en la concepción y la acción política misma, de la racionalidad instrumental y su profesionalización. Es lo que Vázquez Montalbán (1955) resume con su acustumbrada ironía al afirmar que los saberes que el político necesita hoy son dos: el jurídico-administrativo y el comunicacional-publicitario.
description: IBEROAMERICANA, Vol. 8, Núm. 30 (2008)
Estudo clínico-epidemiológico da infeção por Bordetella pertussis num hospital português nível III
Creators: name: Pereira, Joana Grenha
name: Maia, Catarina
name: Fonseca, Jacinta
name: Moreira, Diana
name: João, Anabela
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: Introdução: A incidência da tosse convulsa tem aumentado nos últimos anos sobretudo nos países desenvolvidos, apesar da elevada cobertura vacinal. Os pequenos lactentes são o grupo mais suscetível de complicações. Objetivos: Caracterizar os casos pediátricos de tosse convulsa confirmada laboratorialmente. Determinar fatores clínicos e analíticos preditivos de complicações. Métodos: Estudo retrospetivo observacional por análise dos processos clínicos dos doentes pediátricos internados num hospital português nívelIII com o diagnóstico de tosse convulsa confirmada laboratorialmente de janeirode 2005 asetembro de 2012. Resultados: Identificaram-se 47 casos de infeção por Bordetella pertussis, com dois picos de incidência: em 2008 (25,5%) e em 2012 (29,8%). A mediana da idade foi dois meses, sendo que 76,6% dos casos apresentava idade inferior a três meses. Oito(17%) doentes tinham recebido previamente três ou mais doses de vacina pertussis acelular. Identificou-se a fonte provável de infeção em 42,6% dos casos (pais em 80%). Verificaram-se complicações em 38,3% dos casos, a maioria associada a patologia respiratória. A leucocitose e a linfocitose revelaram-se preditores de tosse convulsa complicada. A reação leucemóide associou-se a elevada morbilidade e mortalidade (um óbito e um caso com sequelas de encefalopatia). Discussão: Neste estudo verificou-se um aumento da incidência da tosse convulsa nos últimos anos, o que questiona a necessidade de adotar estratégias vacinais com o objetivo de diminuir a transmissão da doença. A leucocitose e a linfocitose revelaram-se fatores preditores de complicações. A reação leucemóide cursou com elevada morbi-mortalidade. Palavras-chave: tosse convulsa, pediatria, complicações, leucocitose,linfocitose
description: Portuguese Journal of Pediatrics, Vol. 45 No. 3 (2014)