cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Role of Twist1 in Epithelial-mesenchymal Transition
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastasis is a multi-step process that requires epithelial tumor cells to invade through surrounding extracellular matrix, migrate to distant sites, and form a secondary tumor. Tumor cells have been shown to activate a cellular program called Epithelial-Mesenchymal Transition (EMT) to break away from neighboring cells and migrate to distant tissues. EMT is characterized by epithelial cells losing polarity and adhesion, and gaining a more migratory morphology. Studies from our lab demonstrated that Twist1, a transcription factor that induces EMT during development, is essential for the ability of breast tumor cells to metastasize from the mammary gland to the lung in mice. These results suggest that carcinoma cells activate the EMT program to gain motility, invade, and metastasize.

 Despite evidence supporting the role of EMT in tumor metastasis, this process remains controversial due to the limited observation of human carcinoma transitioning from an epithelial to mesenchymal morphology in clinical samples. One model explaining this observation hypothesizes that primary epithelial tumors undergo EMT to disseminate to distant sites; afterwards they undergo a reverse process, called Mesenchymal-Epithelial Transition (MET), to establish secondary tumors in distant organs. However, the role of this reversible EMT process in tumor metastasis in vivo has not been demonstrated.

 To better understand how Twist1 regulates the EMT/MET process during breast tumor progression, we plan the following studies:

 1) Establish a 3-dimensional mammary “organoid culture system” to visualize and study EMT.

 2) Determine the mechanism for Twist1-induced EMT in 3D mammary organoids.

 3) Determine the role of Twist1 on EMT and metastasis during breast tumor progression.

 Using the organoid culture system, we can study how Twist1 influences cell polarity and basement membrane integrity, both important processes during tumor progression. For our breast tumor studies, we will use a mouse breast tumor model that mimics human breast tumors with Her2 amplification, an ideal model to study the role of Twist1 and EMT on tumor metastasis. Understanding the regulation of the EMT/MET process in animal models is critical for discerning how tumor cells spread to distant sites in human disease pathogenesis. This project will develop and use novel preclinical models to better dissect the EMT program to identify biomarkers as potential targets for therapy.
Drosophila reticulata Wheeler 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila reticulata

description: reticulata Wheeler, 1957: 101. Type locality: Colombia, 30 km NW Medellín, 8000 ft. HT M (USNM). NT Distr.: Colombia (Bucaramanga), Venezuela.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 730, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Hemitrygon longicauda
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Hemitrygon
Hemitrygon longicauda

description: Hemitrygon longicauda (Last & White, 2013)
Merauke Stingray
Dasyatis longicauda Last & White, 2013: 3, Figs 1 –6. Holotype: MZB 21462. Type locality: Merauke, West Papua, Indonesia.
Local synonymy: Dasyatis fluviorum— Kailola, 1987: 28 (Port Romilly; Yule Island; Bootless Bay; Orangerie Bay; south of Ramu River mouth). Dasyatis longicauda —Last et al., 2016a: 557 (southern New Guinea). Hemitrygon longicauda— White et al., 2018: 226, figs (PNG).
PNG voucher material: (15 spec.) CSIRO H 7798-01, female 140 mm DW, CSIRO H 7798-02, juvenile male 160 mm DW, CSIRO H 7798-03, juvenile male 140 mm DW, west of Oriomo River, Western Province, 9°4’26.04” S, 143°8’31.9” E, <1 m depth, 25 Oct. 2014; CSIRO H 8020-01, female 250 mm DW, east of Fly River mouth, Gulf of Papua, 8°34’22” S, 144°4’31” E, 9 m depth, 1 Apr. 2015; CSIRO H 8022-01, female 220 mm DW, CSIRO H 8022-02, female 290 mm DW, CSIRO H 8022-03, female 310 mm DW, east of Fly River mouth, Gulf of Papua, 8°13’6” S, 144°7’24” E, 7–10 m depth, 2 Apr. 2015; CSIRO H 8024-01, female 240 mm DW, southwest of Deception Bay, Gulf of Papua, 8°6’39” S, 144°25’45” E, 12–15 m depth, 3 Apr. 2015; KFRS E.645, juvenile male 120 mm DW, east of Fly River mouth, Gulf of Papua, 8°13’6” S, 144°7’24” E, 7–10 m depth, 2 Apr. 2015; KFRS E.685, female 140 mm DW, KFRS E.686, female 140 mm DW, KFRS E.687, female 160 mm DW, KFRS E.688, female 140 mm DW, west of Oriomo River, Western Province, 9°4’26.04” S, 143°8’31.9” E, <1 m depth, 25 Oct. 2014; KFRS E.798, female 258 mm DW, KFRS E.799, juvenile male 137 mm DW, no collection data [no label but probably previously registered specimens collected in the 1960s or 1970s].
Remarks: First recorded in PNG by Kailola (1987), but specimens in the KFRS collection identified as Dasyatis fluviorum, now lost, which are most likely this species were collected in the mid-1960s. Common in very shallow waters in the Western, Gulf and Central Provinces. Previously placed in the genus Dasyatis.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on pages 53-54, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Developing inhibitors of SEVI-enhanced transmission of HIV
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The goal of this research is to test a novel strategy for attenuating transmission of HIV-1 by neutralization of a recently discovered Semen-derived Enhancer of Viral Infection (SEVI). SEVI is an abundant peptide found in semen that aggregates into large amyloid fibrils. These peptides facilitate the attachment and internalization of HIV in cells. This SEVI-mediated process was shown to enhance HIV-1 infection by up to 400,000-fold compared to infection in the absence of aggregated SEVI peptides. We propose that formation of bio-resistive molecular coatings on aggregated SEVI amyloids using amyloid-targeting agents will mitigate the role of these amyloidogenic peptides in HIV-1 infection. The concept of a bio-resistive coating is based on the hypothesis that small molecules that bind to aggregated amyloids with high density and uniformity can exhibit collective functional properties, such as the capability to inhibit the interaction of the aggregated amyloids with other cellular components (in analogy to “Scotch-guarding” or “Teflon-coating” the amyloids). Our group was the first to introduce a bio-resistive coatings strategy to neutralize the toxicity of aggregated amyloid-beta (Abeta) peptides in Alzheimer’s disease. Here, we wish to extend this concept to test whether amyloid-targeting molecules can also be used to attenuate the effects of SEVI-derived amyloids on HIV transmission. Curtailing the spread of HIV is a major concern for residents in the State of California, and, therefore, this research is well within the scope of this California research grant initiative. We have already obtained preliminary results demonstrating that one of our proprietary amyloid-coating molecules reduces, in a dose-dependent manner, SEVI-mediated HIV-1 infection in a variety of target cells. These preliminary results suggest that the proposed bio-resistive coating strategy is a promising approach to help prevent the spread of HIV. In this proposal, we will explore a new design platform for amyloid-targeting molecules that we expect will be more effective for inhibiting SEVI-mediated enhancement of HIV infection compared to our currently available proprietary molecules. The most promising inhibitors of SEVI-mediated HIV transmission resulting from this developmental research will be further evaluated in future studies for biocompatibility and efficacy in animal models for HIV infection. The ultimate goal of this project will be to identify a set of lead microbicide candidates or supplements that can be advanced towards clinical evaluation as soon as possible.
CXCR4 and CXCR7 Signaling in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chemokines are critical mediators of leukocyte cell migration during routine immune surveillance, lymphocyte development and homing, and inflammation. In parallel with their role in controlling cell migration during immune responses, chemokines and their receptors have been implicated in the cancer metastatic process by directing the migration of tumor cells. The chemokine receptors CXCR4 and CXCR7 are not expressed on normal breast epithelia but they are frequently expressed on breast cancer cells, and there is preferential metastasis of breast cancer cells to sites where their ligand, called CXCL12, is constitutively expressed. However, the exact mechanisms of how CXCR4 and CXCR7 enhance metastasis and/or tumor growth and their full implications on disease progression are unknown. Yet it is likely that chemokine receptor signaling may provide more than just a migrational advantage by also helping the metastasized cells establish and survive in secondary environments.

 The goal of the proposed studies is to characterize the mechanisms and functional roles of CXCL12, and its receptors, CXCR4 (Aim 1) and CXCR7 (Aim 2), in breast cancer. In particular, we plan to characterize how these receptors promote the survival, proliferation, and metastasis of these cancer cells. Two breast cancer cell lines (MDA-MB 231 and MCF-7) will be selected for high expression levels of CXCR4 or CXCR7. The selected cells and the starting population compared in terms of their ability to directly or indirectly promote cell proliferation and survival. They will also be studied using a mouse model of tumor metastasis to gain a better understanding of how receptor expression influences tumor growth and rate of metastasis. Cells from the primary breast tumors and subsequent metastatic sites will be collected to more extensively explore how the chemokine receptor levels have changed and how the cells respond to CXCL12 ligand. Specific inhibitors of CXCR4 and CXCR7 will be used to help dissect the individual contributions of these receptors to breast cancer and

 standard survival and proliferation pathways (e.g., Akt, ERK1/2, NF-?B) will be analyzed for their contribution to chemokine-dependent metastasis.

 The research is distinct from the traditional approaches of understanding the genetic mechanisms of breast cancer malignancy as it is aimed at examining the roles of signals from the local environment in metastasis, which has received much less attention. The potential impact of the proposed research is in making current chemotherapies more effective in destroying metastatic lesions, by combining them with molecules that reduce the inherent viability and growth of cancer cells. Such molecule inhibitors of CXCR4, are already in clinical trials for AIDS, and thus there is potential for such drug combinations to be translated rapidly into cancer therapeutics.
Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia
Creators: name: Khavulya, Dmitry
Publisher: name: No Publisher Supplied
Year: 2012

description: The brain is critically dependent on blood flow and oxygen supply for its normal function. Few existing methods allow rapid noninvasive assessment during critical hypoxic events. A novel technique for recording and analyzing brain auditory evoked potential (BAEP) under hypoxic conditions was developed. Experiments were performed on a healthy subject during hyperventilation (HV) and episodes of periodic breath-holding. Surface electrodes were used to measure EEG (electro-encephalogram) and also BAEP in A2-Cz configuration. Auditory stimuli were applied in the form of 0.1 seconds stream of clicks. An analog circuit and data acquisition system was developed for amplifying, filtering and recording the EEG from Cz-A2 position. Data were digitized online. Signal processing techniques were performed to extract and analyze BAEP using Latency Correction (LC), Ensemble Averaging, Continuous Wavelet Transform (CWT), and Principal Component Analysis (PCA). Results showed that the hypoxic conditions caused depolarization and hyperpolarization, producing aggregate potentials or field potentials. BAEPs can be extracted and analyzed under hypoxic conditions with minimum averaging (400 realizations) allowing real time evaluation of the auditory pathway. Increased activity in the auditory pathway directly following depletion of oxygen to the brain was observed.  The hypoxic condition was confirmed when BAEP was used in combination with a near-infrared spectroscopic device for quantifying oxygenation. Thus, the BAEP system designed here can be used for non-invasive, real-time assessment of the auditory pathway, in identifying abnormal breathing and hypoxic events, and in the evaluation of patients suffering from cerebrospinal injury when used in conjunction with near-infrared oxygenation monitoring system.
Drosophila schildi Malloch 1924
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila schildi

description: schildi Malloch, 1924: 10. Type locality: Costa Rica, Alaiuela, San Mateo, Higuito. HT F (USNM). NT Distr.: Costa Rica to Brazil. Refs.: Wheeler, 1957: 86; Wheeler, 1963: 57.
Paramycodrosophila poeciloptera Duda, 1925: 226. Type locality: Costa Rica, Catargo, La Suiza de Turrialba. LT M (HNHM). Lectotype des. and syn. Wheeler, 1963: 57.
poecila Burla & Pavan, 1953: 311. N. n. poeciloptera Duda, 1925. See Wheeler, 1959: 184.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 730, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
HIV Detection Using the Peptide Beacon Architecture
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The detection of HIV is the first step in treatment of AIDS, as well as an important step in minimizing transmission. Current rapid HIV tests are too expensive for large-scale application (e.g. all patients at a hospital or clinic), and slower HIV tests are not as effective for communicating results to patients and preventing unwanted transmission. This research aims to develop a new application for a biosensor technique called peptide beacons. Peptide beacons are used to detect antibodies characteristic of an infection such as HIV. Infection triggers an immune response from the body, which then produces these antibodies in an attempt to fight off infection. Therefore, HIV antibodies are only present in patients who are HIV positive. Peptide beacons detect the presence of these antibodies in a blood sample by a change in the peptide beacon fluorescence upon binding. The detection technique looks for the characteristic change in beacon fluorescence, and from that one can deduce if a patient is HIV positive. Specifically, this research project has three aims: expand the peptide beacon approach for HIV antibodies, use time-resolved fluorescence to allow better detection limits in realistic samples, and apply the peptide beacon approach for direct detection of the HIV virus, rather than an indirect detection of an immune response. The purpose of the first goal is to apply this platform to HIV detection and, when coupled with the second aim, use this detection technique in realistic samples. The third aim is to create a detection scheme that will be able to detect HIV infection before the body has mounted an effective immune response (before production of antibodies). There are a variety of implications of this research for the citizens of California and more generally, society at large. The development of this biosensor technique will have a large impact in the health and safety of California. Affordable, rapid detection of HIV will allow clinics and hospitals to test more patients in less time for less money, benefiting the state of California as well as anywhere HIV detection is needed. This research can also be extended to the detection of other diseases and pathogens, providing further societal benefits.
Himantura Muller & Henle 1837
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Himantura

description: Genus Himantura Müller & Henle, 1837
Whiprays
Himantura Müller & Henle, 1837b: 400. Type species: Raja sephen uarnak Forsskål, 1775, by subsequent designation.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 54, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Wordimage
Creators: name: Keefe, Anne
Publisher: name: No Publisher Supplied
Year: 2012

description: My dissertation challenges how we conceptualize the relationship between verbal and visual within the ekphrastic encounter. Beginning with the modernist lyrics of H.D. and Marianne Moore and extending to the contemporary poetry of Natasha Tretheway, Sharon Dolin, Siri Hustvedt, Mark Doty, and Mei-mei Berssenbrugge, I argue that the voice, form, and content of the ekphrastic lyric is a productive site for understanding the poetics of aesthetic politics. Dominant theories of ekphrasis such as the rivalry between the sister arts and models of confrontation between poet and painter foreclose on the possibilities of the mode as a political space in which the differences between word and image allow poets to engage in new ways with the solitary, embodied, and viewing lyric voice. While feminist and conceptual poetics have privileged the fragmented, multi-vocal poem as the most political form for negotiating subjectivity, my focus on more humanist lyrics engaging fixed forms and lyric selves illuminates an aesthetic for the 21st century in which modern problems connecting vision and identity such as the gaze, the loss of aura, the uncanny double, and viewer passivity, become transformed into opportunities for rethinking subjectivity and desire.
Himantura australis Last, White & Naylor 2016
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Himantura
Himantura australis

description: Himantura australis Last, White & Naylor, 2016f
Australian Whipray
Himantura australis Last, White & Naylor, 2016f: 378, Figs 1 –5. Holotype: CSIRO H 7798-04. Type locality: west of Oriomo River, Western Province.
Local synonymy: Trygon uarnak— Peters, 1877: 853 (Carteret Islands). Himantura uarnak— Munro, 1958: 114 (Carteret Islands); Munro, 1967: 15 (New Guinea); Filewood, 1973: 12 (PNG); Haines, 1979a: 6 (Purari Delta); Haines, 1979b: 94 (Purari Delta); Taniuchi & Shimizu, 1991: 5 (Oriomo River estuary). Himantura fava— Kailola, 1987: 28 (Yule Island). Himantura australis Last et al., 2016f: 378, Figs. 1 –5 (Western Province); Last et al., 2016a: 561 (New Guinea); White et al., 2018: 228, figs (PNG).
PNG voucher material: (11 spec.) CAS SU 28205, juvenile male 277 mm DW, Rabaul, East New Britain, 28 Apr. 1929; CSIRO H 8100-03, juvenile male 237 mm DW, Motupore Island, Bootless Bay, 9°31'19" S, 147°17'2" E, <1 m depth, 15 Sept. 2016; CSIRO H 7798-04 (holotype), juvenile male 415 mm DW, west of Oriomo River, Western Province, 9°04.43’ S, 143°08.53’ E, 25 Oct. 2014; CSIRO H 7839-01 (paratype), juvenile male 333 mm DW, Daru fish market, Western Province, 9°03.91’ S, 143°12.59’ E, 21 Oct. 2014; CSIRO H 7840-01 (paratype), juvenile male 241 mm DW, fishing camp near Daru, Western Province, 9°02.26’ S, 143°11.49’ E, 24 Oct. 2014; KFRS E.123, female 292 mm DW, Yule Island, Central Province, Aug. 1964; KFRS E.615, juvenile male 240 mm DW, Mullins Harbour, 10°26’50” S, 145°56’27” E, <1 m depth, 11 Mar. 2016; KFRS E.768 (paratype, field accession 230247), late-term embryo 300 mm DW (from female 1400 mm DW), south of Purari River, Gulf of Papua, 7°55’S, 145°09’ E, 16–18 m depth, 1 Dec. 2014; KFRS E.769 (paratype, field accession 220349), juvenile female 350 mm DW, Katatai, Western Province, 9°01.25’ S, 143°20.51’ E, 23 Oct. 2014; KFRS E.770 (paratype, field accession 220420), juvenile female 286 mm DW, fishing camp near Daru, Western Province, 9°02.26’ S, 143°11.49’ E, 24 Oct. 2014; USNM 218545, juvenile male 280 mm DW, east side of Daru wharf, Daru, 10 Oct. 1975.
Remarks: First recorded from PNG by Peters (1877) as Trygon uarnak. Previously thought to be conspecific with the wider ranging Himantura uarnak (Gmelin, 1789) but recently separated as a distinct species found in northern Australia and New Guinea; records from northern PNG and the outer islands, e.g. the Carteret Islands, need to be validated as being this species. Common in bycatch of the Gulf of Papua prawn trawl fishery and coastal seine net fisheries during recent surveys.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 54, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Ischemic-hypoxic perinatal conditions and attention deficit hyperactivity disorder
Creators: name: Getahun, Darios
Publisher: name: No Publisher Supplied
Year: 2012

description: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder in the nation affecting 8%-13% of all school-aged children. ADHD diagnoses have reached epidemic proportions in the U.S. with an estimated annual cost of $36 to $52.4 billion, in 2005 dollars.    The etiology of ADHD is largely unknown. Emerging evidence suggests that Ischemic-hypoxic conditions (IHC) have profound effects on fetal brain development that are not apparent in infants. Given that rates of ADHD are increasing and IHC increases the risk of fetal brain injury, we hypothesize that IHCs are important and independent risk factor for ADHD.    In this nested case-control study, we evaluated the risk of ADHD in a cohort of children aged 5-11 years, born at ≥28 weeks of gestation, and cared for at Kaiser Permanente Southern California (KPSC) between 1995-2010 (n =308,634; 4.3% had ADHD). Electronic clinical, laboratory, and pharmacy records were obtained for these children and their mothers. Cases were children with a clinical diagnosis of ADHD (ICD-9 codes 314.x) and positive for at least 2 ADHD prescriptions during the follow-up period. For each case, five controls were matched to cases on child age at diagnosis. IHC was defined based on ICD-9 codes.     Compared to control children, case children were more likely to be male and of white or black race/ethnicity. Mothers of case children were more likely to be older, have ≥12 years education, history of smoking and psychosocial disorders during pregnancy. In contrast to control children, case children were more likely (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.11, 1.21) to experience IHC. Stratified analyses by gestational age revealed that case children than controls were more likely to experience IHC at 28-33 (OR 1.5, 95% CI 1.2, 2.0), 34-36 (OR 1.2, 95% CI 1.1, 1.5), and 37-42 (OR 1.1, 95% CI 1.0, 1.2) weeks of gestation. IHC was associated with increased odds of ADHD across all race/ethnicity groups.    These findings suggest that IHC is an independent risk factor for ADHD, especially in preterm birth. This suggests that events in pregnancy contribute to the etiology of this condition over and above the well-known familial/genetic influences.
Revenge is a dish best served on a broken plate
Creators: name: Gabrielsen, Dag
Publisher: name: No Publisher Supplied
Year: 2012

description: Does an artist create in a vacuum or is there more at stake in a work’sproduction than art for art’s sake? A great deal has been written about The Riteof Spring by Igor Stravinsky and the atonal works of Arnold Schoenberg, much ofwhich has depicted their works as autonomous objects – objects that embodiedan inevitable step in a natural evolution of Western art music. This essayreconsiders these works not as the product of Hegelian evolution, but as socialacts of symbolic violence against cultural establishments in Saint Petersburg andVienna by two remarkably similar personalities. Following an overview of theirsocial and professional development, this essay considers primary sources onStravinsky and Schoenberg in light of recent psychological research on identity.The system of sign and myth outlined by semiologist Roland Barthes is thenbrought to bear on Stravinsky’s Rite and Schoenberg’s Erwartung to furtheranalyze conservative versus radical reception of these works. The essay concludes with a discussion of the concepts of cultural capital, symbolic violence and collective misrecognition proposed by the sociologist Pierre Bourdieu as they relate to theoretical and historical writing on Stravinsky and Schoenberg later in the twentieth-century.
The modern monarch
Creators: name: Florek, Olivia Gruber
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation examines painted, photographic, and printed portraits of Empress Elisabeth of Austria (1837-1898) as sites for the visualization of modern women. A renowned beauty whose images were collected by individuals of every social class across the continent, Elisabeth was both a producer of culture and an instrument in the expression of larger political, psychological, and artistic forces. Pairing visual analysis with archival research, historical contextualization, and theoretical frameworks drawn from visual culture, photography, and the history of psychiatry, Elisabeth’s portraits emerge as active participants in the modernist project.     Chapter 1 situates Elisabeth’s portraiture within the historiography of nineteenth-century modernism. Her simultaneously theatrical and self-protective beauty reveals how the phenomenon of celebrity influenced female portraiture. The second chapter examines how Habsburg artists appropriated Elisabeth’s photographic image to project their own vision of femininity. Inexpensive photolithographs of the imperial family integrate photographs of Elisabeth to create narratives of domestic bliss. I argue that photographic technology was central to the success of these images because the trace of Elisabeth’s body masked the reality of her difficult relationship with her Habsburg relatives and refusal to perform the public duties of empress.  Chapter 3 explores how Elisabeth created her own construction of feminine beauty using carte-de-visite portraits of beautiful women she requested from her foreign ambassadors.  Elisabeth’s beauty albums pair Parisian courtesans with reproduced paintings of the French Empress Eugénie, suggesting an equivalence between empress and entertainer; this sensibility is visualized in Elisabeth’s 1865 state portrait by Franz Xaver Winterhalter.  The fourth chapter links portraits of Elisabeth by Winterhalter and Anton Romako to the visual culture of psychiatry. As a woman who struggled publicly with mental instability, I argue that Elisabeth’s portraits allowed artists to visualize mental illness as an alluring, modern disease.  In identifying portraits of Elisabeth as sites for the development of modernism, this dissertation introduces a sphere of visual and political imagery typically excluded from examinations of avant-garde artwork in the nineteenth century. Additionally, this dissertation undermines the traditional narrative of Vienna 1900 as an abrupt break from the past by revealing mid-century roots for the celebrated art of Viennese modernism.
Drosophila setula Heed & Wheeler 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila setula

description: setula Heed & Wheeler, 1957: 18. Type locality: Colombia, Fusagasugá. HT M (USNM) NT Distr.: Costa Rica to Brazil, Colombia (Cundinamarca).
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 731, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Himantura leoparda Manjaji-Matsumoto & Last 2008
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Himantura
Himantura leoparda

description: Himantura leoparda Manjaji-Matsumoto & Last, 2008
Leopard Whipray
Himantura leoparda Manjaji-Matsumoto & Last, 2008: 294, Figs 1 –4. Holotype: CSIRO H 2903-01. Type locality: northwest of Weipa, Gulf of Carpentaria, Queensland, Australia.
Local synonymy: Himantura leoparda— Manjaji-Matsumoto & Last, 2008: 293 (PNG); White et al., 2018: 230, figs (PNG).
PNG voucher material: (7 spec.) CSIRO H 7614-12, juvenile male 380 mm DW, south of Kerema, Gulf of Papua, 8°3’1.2” S, 145°45’7.2” E, 16–17 m depth, 20 Jun. 2014; CSIRO H 7807-02, juvenile male 420 mm DW, southwest of Kerema, Gulf of Papua, 8°2’22.2” S, 145°37’13.2” E, 15–16 m depth, 15 Jun. 2014; CSIRO H 7809- 0 1, juvenile male 400 mm DW, south of Kerema, Gulf of Papua, 8°1’53.4” S, 145°43’0.6” E, 16–18 m depth, 18 Jun. 2014; CSIRO H 7820-01, juvenile male 400 mm DW, south of Deception Bay, Gulf of Papua, 8°7’ S, 144°29’ E, 18 m depth, 1 Dec. 2014; KFRS E.643, juvenile male 450 mm DW, east of Fly River mouth, Gulf of Papua, 8°34’22” S, 144°4’31” E, 9 m depth, 1 Apr. 2015; KFRS E.722, juvenile male 400 mm DW, south of Kerema, Gulf of Papua, 8°2’9.6” S, 145°42’29.4” E, 14–15 m depth, 17 Jun. 2014; KFRS E.747, female 470 mm DW, east of Fly River mouth, Gulf of Papua, 8°36’ S, 144°1’ E, 11–15 m depth, 11 Dec. 2014.
Remarks: First listed as from PNG in Manjaji-Matsumoto & Last (2008); first confirmed record based on specimens. Common in bycatch of the Gulf of Papua prawn trawl fishery.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 55, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Drosophila starmeri Wasserman, Koepfer & Ward 1973
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila starmeri

description: starmeri Wasserman, Koepfer & Ward, 1973: 1239. Type locality: Venezuela, Lara, 10-15 km W Barquisimeto. HT M?. NT Distr.: Venezuela to Chile. Colombia (La Guajira (Riohacha: Camarones), Magdalena (Santa Marta), Huila (Desierto de la Tatacoa: Rosalia)). Refs.: De Polanco et al., 2008: 106.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 731, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
title: Effect of environmental factors and polyketide synthase gene expression in an usnic acid producing lichen-fungus, Cladonia uncialis in its natural habitat and under controlled laboratory conditions
Creators: name: Watalabbe Gamaralalage, Duleeka Indeewaree Gunawardana
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2025

description: One of the most studied lichen secondary metabolites is usnic acid, which is thought to be linked to harsh environmental conditions and potentially mediated by methylphloracetophenone synthase (mpas) and methylphloracetophenone oxidase (mpao) genes in Cladonia uncialis. Chapter 2 examined the relationship between neighboring lichen species composition and soil pH, soil moisture content associated with C. uncialis in three locations in Newfoundland. Results showed that abundance of C. uncialis, C. stellaris, and C. arbuscula correlated with the soil pH, and Cetraria islandica, C. arbuscula, and C. boryi correlated with the soil moisture content. As this study showed that moisture and pH correlated with the ground cover of C. uncialis, these environmental factors were further examined to test their influence on usnic acid production and gene expression (Chapter 3). Results showed that correlation of percent ground cover of C. uncialis, and significant mpao upregulation by soil pH. Since mpas gene expression did not correlate to soil pH under natural habitat, only mpao, in Chapter 4, I tested the effect of pH and temperature on mpas and mpao gene expression and usnic acid production in C. uncialis under controlled laboratory conditions. Results showed a significant effect of pH levels on usnic acid production and a significant effect of temperature on mpas and mpao upregulation. Both gene expression changes were consistently observed in the second week, while usnic acid was detected in high concentrations only after eight weeks of experiments. Based on these results, chapter 5 investigated mpas and mpao activation with UV-B light, which is known to trigger the usnic acid biosynthesis in lichen fungi. Results showed that UV-B light significantly impacted the upregulation of both mpas and mpao genes. Since the overall experiment was based on only C. uncialis lichen fungi, chapter 6 screened mpas activity in a wide range of lichen species, including usnic acid-producing and non-usnic acid-producing lichen species. Results suggested that species that produce usnic acid showed higher mpas activation, providing evidence to support that mpas is responsible for usnic acid production in lichen fungi other than in C. uncialis. These findings warrant further investigation of usnic acid biosynthesis and advance understanding of the regulation of genes involved in this process.
Maculabatis Last, Naylor & Manjaji-Matsumoto 2016
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Myliobatiformes
Dasyatidae
Maculabatis

description: Genus Maculabatis Last, Naylor & Manjaji-Matsumoto, 2016b
Whiprays
Maculabatis Last, Naylor & Manjaji-Matsumoto, 2016b: 361. Type species Trygon gerrardi Gray, 1851, by original designation.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 55, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Early CTL targeting differs in B57 slow vs. fast progressors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Although our immune systems are able to help us recover from almost every kind of viral infection, HIV is an exception, and if not treated, leads to AIDS disease within 8 years of infection in most people. Intriguingly, a small percentage of people are able to exert effective immune control of the virus and delay illness for much longer, beyond 25 years in some cases. Since the goal of an HIV vaccine is to elicit effective immune responses to the HIV virus, these rare individuals offer an excellent opportunity to identify the features of a successful immune response to HIV. One obstacle to this type of investigation is that the immune responses in the first months after infection are the most critical to long-term disease resistance outcomes; the long lag between infection and evidence of long-term immune control has hampered efforts to link early immune events with successful long-term outcomes. The Multicenter AIDS Cohort Study (MACS) has volunteers from at-risk and HIV-infected American populations who have contributed samples every six months for over 25 years, that have been cryopreserved in a longitudinal archive. In a preliminary correlation study, we have been able to take advantage of these unique samples and go back and compare the early immune responses in those people who have been able to control HIV without medication with the immune responses in those who have not. We were intrigued to find a particular immune response that was common in those who eventually controlled HIV, but rare in those who did not. This correlation suggests that this particular immune response, in which cytotoxic (killer) T cells target of a part of the HIV capsid protein, may directly confer protection. In order to test this hypothesis, we will conduct a pilot study in which we will culture the cytotoxic T cells from the volunteers who have demonstrated long-term immune control, and compare the ability of the cells that target different parts of the HIV capsid protein to (a) control HIV replication in a petri dish and (b) recognize the virus even when its capsid protein mutates. If we find that the cytotoxic T cells we identified in the correlation study have superior antiviral activity in culture, then future studies will investigate both the cellular characteristics that underlie this antiviral effectiveness, and the early events in HIV infection that lead to the production of this type of cytotoxic T cell. By understanding the cellular and molecular mechanisms of natural immune control of HIV, we can try to mimic these mechanisms when designing a vaccine.
Novel functions of Human Immunodeficiency Virus protein Vif
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV encodes viral protein Virion Infectivity Factor (Vif) and it is essential for viral invasion of host innate immunity. In the absence of Vif, the viral replication is restricted by host anti-HIV factor APOBEC3G, which is a cytidine deaminase that induces modification of cytosines to uracils in newly synthesized viral DNA, resulting in non-functional viruses. Previous studies revealed that Vif hijacks host E3 ubiquitin ligase complex to induce degradation of APOBEC3G and counteracts host innate defense to allow continuous viral replication. Recently, two independent studies (Lager et al, Zhang et al, Nature 2012) discovered that Vif also interacts with host factor CBFß, which is crucial for degradation of APOBEC3G. Besides its role in Vif-mediated APOBEC3G degradation, CBFß is also a constitutive binding partner for RUNX proteins. RUNX proteins are key transcription factors for lineage-specific gene expression in several major developmental pathways. Runx1 and Runx3 play key roles in hematopoiesis and multiple stages of T cell differentiation. Both Runx1 and Runx3 are expressed at high level in HIV target cells, including CD4+ T cells and macrophages. Our preliminary data indicate that instead of inducing degradation of Runx proteins, Vif associates with Runx/CBFß complex and is translocated into the nucleus with the transcription complex. Moreover, our experiments suggest Vif modifies Runx/CBFß regulation on its target genes, including IL-2 and IFNg. However, global effects of Vif on Runx target genes, how Vif affects Runx/CBFß transcriptional activity and T cell differentiation is unknown. The proposed study will reveal novel functions of Vif in association with Runx/CBFß complex and provide new insights on viral-host interaction during HIV infection.
Drosophila sticta Wheeler 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila sticta

description: sticta Wheeler, 1957: 96. Type locality: Honduras, Lancetilla. HT M (USNM). NT Distr.: El Salvador to Colombia (Valle del Cauca (Buenaventura, Palmira)). Refs.: Pipkin et al., 1966: 146.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 731, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Graphene and its derivatives
Creators: name: Defino, Juliet L.
Publisher: name: No Publisher Supplied
Year: 2012

description: This thesis is composed of a review on the rapidly growing field of graphene research and an experimental investigation of a synthesis method to produce high quality graphene on insulating substrates via diffusion of carbon through nickel.  The history, synthesis, characterization, properties, and applications of graphene and its derivatives are comprehensively discussed in the review.  Historical milestones span the first theoretical publication on graphene in 1947 to K. S. Novoselov and A. K. Geim’s groundbreaking discovery in 2004.  A variety of physical and chemical synthesis techniques have been discovered, each with their own advantages and disadvantages.  Several forms of microscopy and spectroscopy have been utilized to realize the material’s exceptional structural, electronic, optical, mechanical, and thermal properties.  Together, these qualities have justified graphene thin films’ capability to be integrated into a widespread collection of electronic devices.    The objective of the experimental section is to explore a novel synthesis procedure entailing the spin coating of a carbon solution onto a thermally evaporated 40 nm layer of nickel on a SiO2/Si substrate.  The samples were annealed at 50°C, 100°C, 150°C, 200°C, or 400°C for 4 hours to initiate the diffusion of carbon through the metal and deposition onto the substrate.  Etching of the metal and excess carbon source material took place in a 5:1 HCl and HNO3 solution.  Distinctive D, G, and 2D peaks at around 1350 cm-1, 1580 cm-1, and 2700 cm-1 in the Raman spectra indicated the material was graphitic, but an increasing slope in the Raman shift suggested that the nickel layer was still present.  2D/G integrated intensity area ratios showed a peak somewhere between 100° and 150°C, which implied an ideal growth temperature within that range.  D/G area ratios exhibited unexpected and questionable behavior.  Despite these inconclusive results, a recent paper by Kwak et al proposing a similar growth method did in fact prove that high quality few layer graphene sheets can be successfully produced via this technique.  A brief review of that paper is included.
Epomophorus crypturus Peters 1852
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Pteropodidae
Epomophorus
Epomophorus crypturus

description: Epomophorus crypturus Peters 1852
This species was recorded at seven localities north of the Zambezi River (Appendix I), where it was captured in relatively large numbers (e.g., nine individuals at a single site).
Field measurements: FA (adult male) 83.7 ± 1.11 (82.7–84.9, 3); Bm (adult male) 107.7 ± 2.52 (105–110, 3); FA (adult female) 78.7 ± 3.13 (75.7–81.6, 4); Bm (adult female) 79.0 ± 8.29 (70–89, 4).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on pages 371-391, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
The preliminary examination of the integrationof an indoor-walking DVD in NJ SNAP-Ed and EFNEP nutrition education classes
Creators: name: Corda, Kirsten White
Publisher: name: No Publisher Supplied
Year: 2012

description: Obesity has been identified as a significant cause of death and disease among Americans.  Therefore, increasing the prevalence of physical activity is a public health goal.  The literature has pointed towards the efficacy of walking programs to increase physical activity.  However, there is a need for more-inclusive, theory-driven interventions among larger, more diverse audiences.  Using an indoor-walking digital video disc (DVD) with a diverse cast, this dissertation project aimed to contribute towards closing gap in adult physical activity education research.    The research aim of this project was to assess the viability of using the DVD in NJ SNAP-Ed and EFNEP classes which serve limited-resource, diverse adults.  Study participants’ change in barriers to physical activity, stage of exercise, and dietary intake were tested using a randomized, repeated measures design.  As a result of exposure to the DVD, participants’ barriers to physical activity decreased and exercise habits were maintained without detriment to the primary purpose of nutrition education.  These findings bode well for the future use of the DVD as a strategy to promote sustainable, moderate-intensity, leisure time physical activity among limited-resource adults.
Understanding the Mechanisms of Smoking Induced Squamous Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Premalignant lesions occur in the proximal airway epithelium after smoking injury and are thought to undergo stepwise progression from low-grade to high-grade lesions and ultimately to invasive squamous lung cancer (SLC). However, premalignancy of the airway is poorly understood; most of these premalignant lesions will resolve, and the mechanisms of premalignant lesion formation and resolution are not known. It is also not known which lesions will go on to progress to SLC and how this process occurs. A novel approach to cure patients of lung cancer is to develop a targeted chemoprevention strategy to prevent the formation of premalignant lesions and therefore SLC in the first place. This approach requires a good understanding of the biology of airway premalignant lesions and stepwise progression to SLC. Understanding the gene expression changes within cell populations in the airway, premalignant lesions and SLC will allow us to understand how stepwise progression occurs. We hypothesize that the gene expression profiles of individual cells undergoing transformation to SLC will allow us to understand the cell of origin for premalignant lesions and SLC and the mechanisms involved in stepwise progression to SLC. Understanding this process will allow us to prevent the excessive proliferation of premalignancy and impact the lung cancer field by developing a novel chemoprevention strategy for SLC. We propose to achieve our goal with the following Specific Aims: Specific Aim 1: To identify gene expression profiles of single cells in normal human airway epithelium and SLC cell lines to determine heterogeneity of these cell populations and find common signatures that could be associated with lung carcinogenesis. Specific Aim 2: to perform high throughput single cell sequencing of histologically normal airway epithelium, premalignant lesions and SLC from patients. We will characterize the heterogeneity between subpopulations of cells that associate with the presence of lung cancer.