cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EXPERIMENTAL AND NUMERICAL MODELLING OF ENCASED STONE COLUMN.pdf
Creators: name: Ibrahim, Mahmoud
Publisher: name: figshare
Year: 2020
Subjects: subject: 90501 Civil Geotechnical Engineering
subject: FOS: Civil engineering

description: Geosynthetic-Encased sand columns (GECs) provide an effective alternative to
stone columns in very soft soils where stone columns are generally not considered viable.
Coastal and marine zones usually have layers of very soft to soft clays where the use of
GECs can be effective in ground improvement. With increasing depth of very soft to soft
clays (eg. up to 45m in Port Said, Egypt), the use of partially penetrating (i.e. floating)
columns can be cost-effective.
The aim of this study is to investigate the effectiveness of partially penetrating
encased sand columns on the settlement, and bearing capacity. In addition, the
consolidation process, stress transfer mechanism, and developed hoop strains are
investigated through small-scale experimental model tests and numerical modelling.
Very soft clay was brought from the excavation works at the Port Said car tunnel, Port
Said, Egypt. The clay and sand properties were determined through laboratory testing.
The model testing was performed in a 2m long, 1m wide, 1m deep steel tank. The test
bed was prepared by placing the soft clay in layers. In each model test, four 0.05 m
diameter encased sand columns were placed by the displacement method at 0.125 m
spacing. A rigid footing was placed on top of the GECs. Loading was then applied
through a loading frame at constant load increments up to failure. The model tests were
monitored using LVDTs, a load cell, pressure plates, pore pressure transducers, and strain
gauges. The instrumentation was used to measure footing load and settlement, vertical
stresses transferred to the soil and columns, pore pressure generation and dissipation, and
hoop forces developed in the reinforcement. An experimental test for a partially
penetrating GEC was modeled using the 3D finite element program (Plaxis 3D) for
verification purpose. The experimental and numerical models were compared for
settlement, stress concentration, excess pore pressure generation and dissipation, and
hoop strains in the reinforcement.
Using GECs with penetrating length ratios of 1.0, 0.8, and 0.6 resulted in settlement
reductions of 82%, 80%, 68%, respectively, at a vertically applied load of 36 kPa. The
maximum hoop strain was observed at the top of the GECs. It is noticed that hoop strains
along the GEC were similar for the penetration ratios of 0.8 and 1.0, while the hoop
strains increased significantly at a penetration ratio of 0.6. The stress concentration
ratio (ratio of vertical stress on a column to vertical stress on surrounding soil) increases
with the decrease in column-penetrating ratio. Consequently, the developed excess pore
pressures decrease with a reduction in penetration ratio. Good agreement was observed
between the results of the experimental and numerical models.
Phytochemical Screening and GC-MS Analysis of Bioactive Constituents in the Methanolic Extract of Caulerpa racemosa (Forssk.) J. Agardh and Padina boergesenii Allender & Kraft
Creators: name: Cholaraj Ragunath
Publisher: name: King Mongkut's Institute of Technology Ladkrabang
Year: 2020
Subjects: seaweeds, phytocompounds, antimicrobial activity

description: Current Applied Science and Technology, 20, 3, 380-393
Motion-energy-based unequal error protection of H.264/AVC video bitstreams
Creators: name: Thuy, Pham
Publisher: name: Charles Darwin University
Year: 2015

description: Video compression technology is being introduced as one of the main features of the current and next generations of broadband networks. H.264 Advanced Video Coding (AVC) is the most applicable and ecient compression standard. As human eyes are very sensitive to the motion activities, an error occurring in the motion region signicantly degrades the video performance. In recently proposed techniques, the motion activity of frames has been evaluated by the pixel luminance dierence or number of blocks moved between consecutive frames. These techniques have a high complexity, as their calculations must be done at pixel level. In H.264/AVC standard, a video frame is divided into sub-macroblocks, where each sub-macroblock has a number of pixels located in square or rectangular shapes. This thesis proposes a new concept to evaluate the motion activity of video frames, which is called motion energy. It is related to the distance of the sub-macroblock moved between consecutive frames and its size. Indeed, the motion energy concept uses parameters that are directly related to motion activities. Hence, it is more accurate than previously proposed techniques, when luminance is applied in the determination of motion activities. Thesis also introduces new multi-level error protection techniques for the video bitstream formatted by the Group of Pictures (GOP). Frames of a GOP are unequally protected by their motion energies, which are estimated from previous GOPs. The proposed techniques improve the video performance, while maintaining the same overhead existing in other conventional error protection techniques. As delay is not generated in determining the importance of frames by dierent estimation methods, proposed techniques can be applied for real-time video transmission systems.
The organisational politics of taxonomies
Creators: name: Siller, Joy
name: Babikian, Taline
Publisher: name: ISKO UK
Year: 2015
Subjects: taxonomy
taxonomies
organisational politics

description: Taxonomists, system developers and the general information management profession often need to consider the structural principles and design factors that impact organisational taxonomy projects. We suggest that often-overlooked organisational politics can have a significant impact on the structure, content and eventual usability of a taxonomy. Navigating and managing the maze of cultures, behaviours, and attitudes of individuals and groups within organisations can be daunting for anyone. Taxonomists are not necessarily skilled in psychology or focused on organisational behaviour, but they are regularly faced with political situations. They need be aware that these powerful political forces are just as important as any technical issues. This paper aims to assist the taxonomist with this process and add to the body of knowledge on the topic. Theories, case studies and key stakeholders influencing taxonomy projects are discussed, together with the common challenges that can be caused by political power games or resistance. Strategies and tactics to address them are included, where possible.
Piloto para implementar la guía para el desarrollo de la vigilancia comunitaria en albergues, Gramalote, Norte de Santander, 2011
Creators: name: Martínez-Álvarez, Eddier
Publisher: name: figshare
Year: 2014
Subjects: Health Care

description: Durante 2011, el grupo de Análisis de Situación de Salud del INS diseñó una guía para el desarrollo de la vigilancia comunitaria en albergues cuya finalidad es generar alertas tempranas que lleven a la toma de decisiones para brindar una respuesta oportuna a partir del contexto de cada comunidad. En septiembre un equipo del grupo de Análisis de Situación de Salud del INS se desplazó al municipio de Gramalote en el Departamento de Norte de Santander, para realizar la prueba piloto de la guía de vigilancia comunitaria en albergues.
BURDАLАNGАN BETОN LОMINI KОMPLEKS MОDIFIKАTSIYАLАNGАN BETОNLАR TАRKIBIDА TО'LDIRUVCHI VА MINERАL MIKRОTО'LDIRGICH SIFАTIDА ISHLАTISH TEXNОLОGIYАSI
Creators: name: Botirova, Nodira
name: Bozorboyeva, Nozima
name: Muxirboyeva, Zuhra
Publisher: name: Zenodo
Year: 2025

description: Ma’lumki, sementli beton strukturasining shakllanishini uchta davrga ajratsa bo‘ladi: dastlabki davr - ushbu davrda beton qorishmasi betonga aylanadi, keyingi davrda – betonning strukturasi asta-sekin mustahkamlanib boradi, uchinchi davrda – betonning strukturasi stabillashadi va vaqt o‘tishi bilan deyarli o‘zgarmaydi (1.1-rasm.).
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis
Creators: name: Miyoung Lee
name: Venkitaraman, Ashok R
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Defects in the completion of cell division by cytokinesis have long been proposed to foster carcinogenesis by engendering chromosome instability, but few tumor suppressor mechanisms controlling this process have so far been identified. Here, we identify a carboxyl (C)-terminal region of the high-mobility group protein HMG20b that is essential for cytokinesis, and report that it is inactivated by a cancer-associated mutation. We find that a C-terminal region of HMG20b spanning residues 173–317 is necessary and sufficient not only for its localization to cytokinetic structures, but also for its interaction with the tumor suppressor BRCA2, implicated in the abscission step of cytokinesis. Indeed, expression of this C-terminal HMG20b region suffices to restore cytokinesis in HMG20b-depleted cells. The non-conservative substitution of HMG20b residue Ala247 with Pro, reported in human lung cancer, disrupts these activities of HMG20b, impairing cytokinesis in a trans-dominant manner. Our findings provide fresh insight into the mechanism by which the HMG20b-BRCA2 complex controls mitotic cell division, and implicate heterozygous HMG20b mutations affecting cytokinesis regulation in the genesis of human cancers.
Bio-inspired multifunctional zinc oxide nanoparticles by leaf extract of Andrographis serpilifolia and their enhanced antioxidant, antimicrobial, and antidiabetic activity—a 3-in-1 system
Creators: name: Kotakadi, Venkata S.
name: Gaddam, Susmila Aparna
name: Kotha, Peddana
name: Allagadda, Rajesekhar
name: Rao, Appa
name: R., Sai Gopal D. V.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences

description: In this research article, we present a simple and rapid method for synthesis of zinc oxide nanoparticles (ZnONPs) using zinc acetate dehydrate, sodium hydroxide and leaf extract of an important anti-diabetic plant Andrographis serpelifolia (As). The results reveal that UV-visible absorption spectrum indicates peaks at 325 nm which confirms the biosynthesis of ZnONPs. Fourier transform infrared spectroscopy (FT-IR) results indicate the characteristic peak at 511.93 cm−1 for ZnO nanoparticles. EDX analysis revealed the purity of As-ZnONPs and the particle size was between 70 nm and 80 ± 10 nm by both dynamic light scattering analysis (DLS) and Transmission electron microscopy (TEM) analysis. The As-ZnONPs were moderately stable with negative zeta potential value −11.1 mV. Atomic force microscopy (AFM) analysis also revealed the same results as TEM and DLS. The x-ray diffraction (XRD) data revealed that the particles are facets of face-centered cubic crystal structure of ZnO. The As-ZnONPs have exhibited potential antioxidant activity and effective antibacterial activity against gram-positive bacteria. The As-ZnONPs have also potential anti-diabetic activity in vivo (rat model). The antidiabetic activity of As-ZnONPs comparable to that of the standard drug glibenclamide was evidenced by various biochemical parameters like HbA1C, serum lipid profiles, liver and renal functional markers.
A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells
Creators: name: Kurenova, Elena
name: Ucar, Deniz
name: Jianqun Liao
name: Yemma, Michael
name: Gogate, Priyanka
name: Wiam Bshara
name: Ulas Sunar
name: Mukund Seshadri
name: Hochwald, Steven N
name: Cance, William G
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the scaffolding function of tumor related proteins such as focal adhesion kinase (FAK). FAK is overexpressed in most solid tumors and is involved in multiple protein-protein interactions critical for tumor cell survival, tumor neovascularization, progression and metastasis. In this study, we investigated the anticancer activity of the FAK scaffold inhibitor C4, targeted to the FAK-VEGFR-3 complex, against melanomas. We compared C4 inhibitory effects in BRAF mutant vs BRAF wild type melanomas. C4 effectively caused melanoma tumor regression in vivo, when administered alone and sensitized tumors to chemotherapy. The most dramatic effect of C4 was related to reduction of vasculature of both BRAF wild type and V600E mutant xenograft tumors. The in vivo effects of C4 were assessed in xenograft models using non-invasive multimodality imaging in conjunction with histologic and molecular biology methods. C4 inhibited cell viability, adhesion and motility of melanoma and endothelial cells, specifically blocked phosphorylation of VEGFR-3 and FAK and disrupted their complexes. Specificity of in vivo effects for C4 were confirmed by a decrease in tumor FAK and VEGFR-3 phosphorylation, reduction of vasculogenesis and reduced blood flow. Our collective observations provide evidence that a small molecule inhibitor targeted to the FAK protein-protein interaction site successfully inhibits melanoma growth through dual targeting of tumor and endothelial cells and is effective against both BRAF wild type and mutant melanomas.
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis
Creators: name: Miyoung Lee
name: Venkitaraman, Ashok R
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Defects in the completion of cell division by cytokinesis have long been proposed to foster carcinogenesis by engendering chromosome instability, but few tumor suppressor mechanisms controlling this process have so far been identified. Here, we identify a carboxyl (C)-terminal region of the high-mobility group protein HMG20b that is essential for cytokinesis, and report that it is inactivated by a cancer-associated mutation. We find that a C-terminal region of HMG20b spanning residues 173–317 is necessary and sufficient not only for its localization to cytokinetic structures, but also for its interaction with the tumor suppressor BRCA2, implicated in the abscission step of cytokinesis. Indeed, expression of this C-terminal HMG20b region suffices to restore cytokinesis in HMG20b-depleted cells. The non-conservative substitution of HMG20b residue Ala247 with Pro, reported in human lung cancer, disrupts these activities of HMG20b, impairing cytokinesis in a trans-dominant manner. Our findings provide fresh insight into the mechanism by which the HMG20b-BRCA2 complex controls mitotic cell division, and implicate heterozygous HMG20b mutations affecting cytokinesis regulation in the genesis of human cancers.
p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response
Creators: name: Hiroyoshi Hattori
name: Rekin’s Janky
name: Nietfeld, Wilfried
name: Aerts, Stein
name: M Madan Babu
name: Venkitaraman, Ashok R
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been implicated in the DDR, there is as yet no comprehensive description of genome-wide changes in the expression of miRNAs triggered by DNA breakage in human cells. We have used next-generation sequencing (NGS), combined with rigorous integrative computational analyses, to describe genome-wide changes in the expression of miRNAs during the human DDR. The changes affect 150 of 1523 miRNAs known in miRBase v18 from 4–24 h after the induction of DNA breakage, in cell-type dependent patterns. The regulatory regions of the most-highly regulated miRNA species are enriched in conserved binding sites for p53. Indeed, genome-wide changes in miRNA expression during the DDR are markedly altered in TP53-/- cells compared to otherwise isogenic controls. The expression levels of certain damage-induced, p53-regulated miRNAs in cancer samples correlate with patient survival. Our work reveals genome-wide and cell type-specific alterations in miRNA expression during the human DDR, which are regulated by the tumor suppressor protein p53. These findings provide a genomic resource to identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients.
A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells
Creators: name: Kurenova, Elena
name: Ucar, Deniz
name: Jianqun Liao
name: Yemma, Michael
name: Gogate, Priyanka
name: Wiam Bshara
name: Ulas Sunar
name: Mukund Seshadri
name: Hochwald, Steven N
name: Cance, William G
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the scaffolding function of tumor related proteins such as focal adhesion kinase (FAK). FAK is overexpressed in most solid tumors and is involved in multiple protein-protein interactions critical for tumor cell survival, tumor neovascularization, progression and metastasis. In this study, we investigated the anticancer activity of the FAK scaffold inhibitor C4, targeted to the FAK-VEGFR-3 complex, against melanomas. We compared C4 inhibitory effects in BRAF mutant vs BRAF wild type melanomas. C4 effectively caused melanoma tumor regression in vivo, when administered alone and sensitized tumors to chemotherapy. The most dramatic effect of C4 was related to reduction of vasculature of both BRAF wild type and V600E mutant xenograft tumors. The in vivo effects of C4 were assessed in xenograft models using non-invasive multimodality imaging in conjunction with histologic and molecular biology methods. C4 inhibited cell viability, adhesion and motility of melanoma and endothelial cells, specifically blocked phosphorylation of VEGFR-3 and FAK and disrupted their complexes. Specificity of in vivo effects for C4 were confirmed by a decrease in tumor FAK and VEGFR-3 phosphorylation, reduction of vasculogenesis and reduced blood flow. Our collective observations provide evidence that a small molecule inhibitor targeted to the FAK protein-protein interaction site successfully inhibits melanoma growth through dual targeting of tumor and endothelial cells and is effective against both BRAF wild type and mutant melanomas.
p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response
Creators: name: Hiroyoshi Hattori
name: Rekin’s Janky
name: Nietfeld, Wilfried
name: Aerts, Stein
name: M Madan Babu
name: Venkitaraman, Ashok R
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been implicated in the DDR, there is as yet no comprehensive description of genome-wide changes in the expression of miRNAs triggered by DNA breakage in human cells. We have used next-generation sequencing (NGS), combined with rigorous integrative computational analyses, to describe genome-wide changes in the expression of miRNAs during the human DDR. The changes affect 150 of 1523 miRNAs known in miRBase v18 from 4–24 h after the induction of DNA breakage, in cell-type dependent patterns. The regulatory regions of the most-highly regulated miRNA species are enriched in conserved binding sites for p53. Indeed, genome-wide changes in miRNA expression during the DDR are markedly altered in TP53-/- cells compared to otherwise isogenic controls. The expression levels of certain damage-induced, p53-regulated miRNAs in cancer samples correlate with patient survival. Our work reveals genome-wide and cell type-specific alterations in miRNA expression during the human DDR, which are regulated by the tumor suppressor protein p53. These findings provide a genomic resource to identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients.
Species diversity and some aspects of reproductive biology and life history of groupers (Pisces: Serranidae: Epinephelinae) off the central eastern coast of India
Creators: name: Sujatha Kandula
name: Kantimahanti V. L. Shrikanya
name: V. A. Iswarya Deepti
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Physiology

description: Due to increased fishing activity, catches of larger species and individuals decrease. Behaviour, reproductive biology and life history data are fundamental to determine vulnerability to fishing. Groupers (Serranidae: Epinephelinae) are valuable targets for fisheries in many parts of the world but are highly susceptible to heavy and unregulated fishing. For many regions, biological information on groupers necessary for management purposes is still scarce. The North Andhra region, central east coast of India, has been the centre for a variety of fishing activities for a long time. Many species of groupers are landed by a variety of gears at fishing harbours and nearby fishing villages of this region. The present paper incorporates data on species diversity and length groups represented in the catches, results of length-weight relationship studies, length at first maturity, and fecundity of grouper species belonging to two genera, Cephalopholis and Epinephelus, that are represented in the commercial catches of this region. The consideration of length at first maturity and fecundity estimations is a very important prerequisite to prevent exploitation and detrimental effects for these fisheries resources.
Comparative Bioenergetics Modeling of Two Lake Trout Morphotypes
Creators: name: Wagner, Tyler
name: Kepler, Megan V.
name: Sweka, John A.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: Efforts to restore Lake Trout Salvelinus namaycush in the Laurentian Great Lakes have been hampered for decades by several factors, including overfishing and invasive species (e.g., parasitism by Sea Lampreys Petromyzon marinus and reproductive deficiencies associated with consumption of Alewives Alosa pseudoharengus). Restoration efforts are complicated by the presence of multiple body forms (i.e., morphotypes) of Lake Trout that differ in habitat utilization, prey consumption, lipid storage, and spawning preferences. Bioenergetics models constitute one tool that is used to help inform management and restoration decisions; however, bioenergetic differences among morphotypes have not been evaluated. The goal of this research was to investigate bioenergetic differences between two actively stocked morphotypes: lean and humper Lake Trout. We measured consumption and respiration rates across a wide range of temperatures (4–22°C) and size-classes (5–100 g) to develop bioenergetics models for juvenile Lake Trout. Bayesian estimation was used so that uncertainty could be propagated through final growth predictions. Differences between morphotypes were minimal, but when present, the differences were temperature and weight dependent. Basal respiration did not differ between morphotypes at any temperature or size-class. When growth and consumption differed between morphotypes, the differences were not consistent across the size ranges tested. Management scenarios utilizing the temperatures presently found in the Great Lakes (e.g., predicted growth at an average temperature of 11.7°C and 14.4°C during a 30-d period) demonstrated no difference in growth between the two morphotypes. Due to a lack of consistent differences between lean and humper Lake Trout, we developed a model that combined data from both morphotypes. The combined model yielded results similar to those of the morphotype-specific models, suggesting that accounting for morphotype differences may not be necessary in bioenergetics modeling of lean and humper Lake Trout.Received January 6, 2014; accepted August 5, 2014
Foraging and Growth Potential of Juvenile Chinook Salmon after Tidal Restoration of a Large River Delta
Creators: name: Takekawa, John Y.
name: David, Aaron T.
name: Ellings, Christopher S.
name: Woo, Isa
name: Simenstad, Charles A.
name: Turner, Kelley L.
name: Smith, Ashley L.
name: Takekawa, Jean E.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Engineering

description: We evaluated whether restoring tidal flow to previously diked estuarine wetlands also restores foraging and growth opportunities for juvenile Chinook Salmon Oncorhynchus tshawytscha. Several studies have assessed the value of restored tidal wetlands for juvenile Pacific salmon Oncorhynchus spp., but few have used integrative measures of salmon performance, such as habitat-specific growth potential, to evaluate restoration. Our study took place in the Nisqually River delta, Washington, where recent dike removals restored tidal flow to 364 ha of marsh—the largest tidal marsh restoration project in the northwestern contiguous United States. We sampled fish assemblages, water temperatures, and juvenile Chinook Salmon diet composition and consumption rates in two restored and two reference tidal channels during a 3-year period after restoration; these data were used as inputs to a bioenergetics model to compare Chinook Salmon foraging performance and growth potential between the restored and reference channels. We found that foraging performance and growth potential of juvenile Chinook Salmon were similar between restored and reference tidal channels. However, Chinook Salmon densities were significantly lower in the restored channels than in the reference channels, and growth potential was more variable in the restored channels due to their more variable and warmer (2°C) water temperatures. These results indicate that some—but not all—ecosystem attributes that are important for juvenile Pacific salmon can recover rapidly after large-scale tidal marsh restoration.Received April 23, 2014; accepted July 9, 2014
Influence of Forest Road Culverts and Waterfalls on the Fine-Scale Distribution of Brook Trout Genetic Diversity in a Boreal Watershed
Creators: name: Bernatchez, Louis
name: Jean-Baptiste Torterotot
name: Perrier, Charles
name: Bergeron, Normand E.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Marine Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: Habitat fragmentation has become an increasing concern in conservation biology and is of prime importance with the expansion of forest road networks toward boreal and arctic regions. The aim of this study was to evaluate the effects of artificial and natural barriers to fish movement on the fine-scale distribution of genetic diversity in Brook Trout Salvelinus fontinalis. We genotyped 995 individuals sampled from 25 locations in a boreal watershed fragmented by culverts and natural waterfalls. Using a landscape genetics approach, we tested whether the presence of both types of barrier resulted in decreased genetic diversity and increased divergence within isolated locations. Results showed that genetic divergence was enhanced between sites separated by barriers and that genetic diversity was reduced within sites located upstream of barriers. Moreover, the observed changes in levels of divergence and diversity were correlated with the number of barriers. Overall, our results suggested that the effects of culverts and natural waterfalls were similar. To our knowledge, this is the first study illustrating the effects of forest road culverts and natural waterfalls on the distribution of genetic diversity in Brook Trout within a boreal watershed. We discuss our results in the context of boreal forest road network expansion and in light of the need to better understand the potential impacts of road infrastructure on the long-term persistence of fish populations.Received January 24, 2014; accepted July 11, 2014
Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS
Creators: name: Onghena, Matthias
name: Hoeck, Els Van
name: Vervliet, Philippe
name: Scippo, Marie Louise
name: Simon, Coraline
name: Loco, Joris Van
name: Covaci, Adrian
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology

description: In 2011, the European Union prohibited the production of polycarbonate (PC) baby bottles due to the toxic effects of the PC monomer bisphenol-A. Therefore, baby bottles made of alternative materials, e.g. polypropylene (PP) or polyethersulphone (PES), are currently marketed. The principal aim of the study was the identification of major compounds migrating from baby bottles using a liquid–liquid extraction followed by GC/MS analysis. A 50% EtOH in water solution was selected as a simulant for milk. After sterilisation of the bottle, three migration experiments were performed during 2 h at 70°C. A non-targeted liquid–liquid extraction with ethyl acetate–n-hexane (1:1) was performed on the simulant samples. Identification of migrants from 24 baby bottles was done using commercially available WILEY and NIST mass spectra libraries. Differences in the migrating compounds and their intensities were observed between the different types of plastics, but also between the same polymer from a different producer. Differences in the migration patterns were perceived as well between the sterilisation and the migrations and within the different migrations. Silicone, Tritan™ and PP exhibited a wide variety of migrating compounds, whereas PES and polyamide (PA) showed a lower amount of migrants, though sometimes in relatively large concentrations (azacyclotridecan-2-one up to 250 µg kg−1). Alkanes (especially in PP bottles), phthalates (dibutylphthalate in one PP bottle (±40 µg kg−1) and one silicone bottle (±25 µg kg−1); diisobutylphthalate in one PP (±10 µg kg−1), silicone (up to ±80 µg kg−1); and Tritan™ bottle (±30 µg kg−1)), antioxidants (Irgafos 168, degradation products of Irganox 1010 and Irganox 1076), etc. were detected for PP, silicone and Tritan™ bottles. Although the concentrations were relatively low, some compounds not authorised by European Union Regulation No. 10/2011, such as 2,4-di-tert-butylphenol (10–100 µg kg−1) or 2-butoxyethyl acetate (about 300 µg kg−1) were detected. Migrating chemicals were identified as confirmed (using a standard) or as tentative (further confirmation required).
On the brink of the Arctic: Unusual intertidal sub-Arctic kelp associations in the Porsangerfjord, North Norway
Creators: name: Sivertsen, Knut
name: Bjørge, Arne
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences

description: The kelps Laminaria digitata and Saccharina latissima are typically sub-littoral species. It is therefore surprising to find large intertidal kelp beds dominated by these two species in the inner Porsangerfjord, North Norway. The areas of the nine intertidal kelp beds ranged from 0.01 to 3 km2 and covered a total area of 8.3 km2. Both species had a prostrate growth form with short stipes, usually less than 10 cm long, independent of the length of the lamina. The laminae of L. digitata and S. latissima measured 77.0 ± 35.2 cm and 99.4 ± 41.0 cm (mean ± 1 SD), respectively. The associations occurred in sheltered areas with a muddy bottom on wide, flat areas of moraine. The areas are completely drained at low tide. The holdfasts were attached to small pebbles sunk in the mud. The mean biomass density of the two dominant kelp species was 4.1 ± 1.8 kg m−2. The mean biomass of all the algal species in the association was 6.1 ± 2.2 kg m−2. A total of 32 species were identified in the association, of which 16 species were annuals and 16 were perennials. All the species found in the kelp associations are also found in the Arctic. The prostrate growth form of L. digitata and S. latissima, the topography and substrate of the intertidal zone, low summer temperatures, low desiccation and protective sea ice during winter are possible factors contributing to the formation of these unusual intertidal kelp associations.
Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus
Creators: name: Tarus, Bogdan
name: Bertrand, Hélène
name: Zedda, Gloria
name: Primo, Carmelo Di
name: Quideau, Stéphane
name: Slama-Schwok, Anny
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The nucleoprotein (NP) binds the viral RNA genome as oligomers assembled with the polymerase in a ribonucleoprotein complex required for transcription and replication of influenza A virus. Novel antiviral candidates targeting the nucleoprotein either induced higher order oligomers or reduced NP oligomerization by targeting the oligomerization loop and blocking its insertion into adjacent nucleoprotein subunit. In this study, we used a different structure-based approach to stabilize monomers of the nucleoprotein by drugs binding in its RNA-binding groove. We recently identified naproxen as a drug competing with RNA binding to NP with antiinflammatory and antiviral effects against influenza A virus. Here, we designed novel derivatives of naproxen by fragment extension for improved binding to NP. Molecular dynamics simulations suggested that among these derivatives, naproxen A and C0 were most promising. Their chemical synthesis is described. Both derivatives markedly stabilized NP monomer against thermal denaturation. Naproxen C0 bound tighter to NP than naproxen at a binding site predicted by MD simulations and shown by competition experiments using wt NP or single-point mutants as determined by surface plasmon resonance. MD simulations suggested that impeded oligomerization and stabilization of monomeric NP is likely to be achieved by drugs binding in the RNA grove and inducing close to their binding site conformational changes of key residues hosting the oligomerization loop as observed for the naproxen derivatives. Naproxen C0 is a potential antiviral candidate blocking influenza nucleoprotein function.
Exploring Douglas-Peucker Algorithm in the Detection of Epileptic Seizure from Multicategory EEG Signals
Creators: name: Zarei, Roozbeh
name: He, Jing
name: Siuly, Siuly
name: Huang, Guangyan
name: Zhang, Yanchun
Publisher: name: Swinburne
Year: 2024

description: Discovering the concealed patterns of Electroencephalogram (EEG) signals is a crucial part in efficient detection of epileptic seizures. This study develops a new scheme based on Douglas-Peucker algorithm (DP) and principal component analysis (PCA) for extraction of representative and discriminatory information from epileptic EEG data. As the multichannel EEG signals are highly correlated and are in large volumes, the DP algorithm is applied to extract the most representative samples from EEG data. The PCA is utilised to produce uncorrelated variables and to reduce the dimensionality of the DP samples for better recognition. To verify the robustness of the proposed method, four machine learning techniques, random forest classifier (RF), k-nearest neighbour algorithm (k-NN), support vector machine (SVM), and decision tree classifier (DT), are employed on the obtained features. Furthermore, we assess the performance of the proposed methods by comparing it with some recently reported algorithms. The experimental results show that the DP technique effectively extracts the representative samples from EEG signals compressing up to over 47% sample points of EEG signals. The results also indicate that the proposed feature method with the RF classifier achieves the best performance and yields 99.85% of the overall classification accuracy (OCA). The proposed method outperforms the most recently reported methods in terms of OCA in the same epileptic EEG database.
Sequence analysis of mitochondrial DNA hypervariable region I in Thai individuals
Creators: name: Padchanee Sangthong
name: Amporn Jansom
name: Nopparut Chinnabanchonchai
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Plant Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Cell Biology
subject: Engineering

description: Nucleotide sequence analysis of hypervariable region I (HVRI) in human mitochondrial DNA (mtDNA) was investigated in 100 unrelated Thai individuals. A total of 85 variable sites and 423 base substitutions, which consisted of 390 nucleotide transitions and 33 nucleotide transversions were found. The following nucleotide substitutions were found: 48% at 16,223, 31% at 16,304, 30% at 16,332, and 26% at 16,129, respectively. Transition from T to C (43.7%) was the most frequent substitution. The nucleotide insertions were found at two sites with T at position 16,188 and C at position 16,194. Eighty-two haplotypes were investigated of which 72 haplotypes were unique. The most frequent haplotypes (16,108T-16,129A-16,162G-16,172C-16,304C and 16,260T-16,298C-16,355T-16,362C) were observed. From position 16,180 to 16,193, thirteen patterns of polycytosine or C-stretch were observed, whereas 68 Thai individuals were found to be similar to the references. The genetic diversity, random match probability, and discrimination power were estimated to be 0.9943, 0.0156, and 0.9844, respectively.
Effect of CdSe quantum dots doping on the switching time, localised electric field and dielectric parameters of ferroelectric liquid crystal
Creators: name: Shukla, Ravi Kumar
name: Galyametdinov, Yuriy Genadievich
name: Radik Rashitovich Shamilov
name: Haase, Wolfgang
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Biotechnology
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: A systematic study highlighting the effect of cadmium selenide quantum dots (CdSe QDs) with varying concentrations of 0.05, 0.10 and 1.0 wt% doping on the electrooptical and dielectric parameters of ferroelectric liquid crystal (FLC) is presented. No considerable change is observed in phase transition temperature and tilt angle with CdSe QDs doping at lower and higher dopant level. Substantial enhancement of localised electric field at higher doping level (1.0 wt%) of CdSe QDs manifested the ≈48% reduction in the switching response of FLC nanocolloids at 30°C. Reduction in the spontaneous polarisation, dielectric constant and absorption strength could be attributed to the antiparallel correlation among dopant and matrix molecules, ion capturing in the capping additive layer and enhancement of the rotational viscosity of the nanocolloids, respectively. Goldstone mode relaxation frequency is found to be decreased with doping up to 0.10 wt% concentration and showed reverse effect at higher QDs concentration. QDs doping effect on the photoluminescence intensity is also discussed.
Determining the Determined State: A Sizing of Size From Aside/the amassing of mass by a mass.
Creators: name: Kirsh, Marvin
Publisher: name: figshare
Year: 2014
Subjects: subject: General Relativity
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Thermodynamics
subject: Special Relativity
subject: Sociology
subject: FOS: Sociology
subject: Anthropology

description: A philosophical exploration is presented that considers entities such as atoms, electrons, protons, reasoned (in existing physics theories) by induction, to be other than universal building blocks, but artifacts of a sociological struggle that in elemental description is identical with that of all processes of matter and energy. In a universal context both men and materials, when stressed, struggle to accomplish/maintain the free state. The space occupied by cognition, inferred to be the result of the inequality of spaces, is an integral component of both processes and process interpretation; arbitration space, ubiquitous throughout nature, occurred to a vast number of vastnesses, a manifestation of the existence of time dependent mass/number/amount, is argued to be located to the same judging criteria with which principles are determined for sociological purposes: the processes of mind are determined (excuse the pun) to occur as a free state that is reflectively equal to what is construed by the intellect as universe. Scientifically determined states are not free states.
ЎЗБЕКИСТОНДA ШAМОЛ ЭНЕРГИЯСИДAН ФОЙДAЛAНИШНИНГ  ПАРАМЕТРЛАРИНИ ЭКСПЕРИМЕНТАЛ АСОСЛАШ
Creators: name: Очилов, Дилшод
name: Худайназаров, Уткир
name: Юнусов, Обид
Publisher: name: Zenodo
Year: 2024

description: Қишлоқ хўжалиги энергия истеъмолчиларини ишончли энергия билан таъминлаш мақсадида энергия манбаси сифатида шамол электр қурилмаси (ШЭҚ) таклиф қилинган. Мақолада ШЭҚ нинг асосий параметрларидан бири генератор кучланиши ва қувватини паррак айланиши тезлиги билан боғлиқлиги ва турли хил юклама ва шамол тезлигида ШЭҚ қувватини ўзгариш қонуниятларини аниқлаш бўйича ўтказилган экспериментал тадқиқотлар натижалари келтирилган.
Saturating chemical mutagenesis for identification of Francisella genes required for growth
Creators: name: Fisher, Nathan
Publisher: name: figshare
Year: 2014
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This is a funded proposal submitted to the USAMRIID In House Laboratory Innovative Research program in 2009. The bioinformatics sections are especially dated, but the work is ongoing. Please contact me if you find the idea interesting.
SHARE data - Access, documentation and management
Creators: name: RENAUD, Thomas
Publisher: name: Zenodo
Year: 2019
Subjects: SHARE
Survey of Health, Ageing and Retirement in Europe
Metadata

description: The Survey of Health, Ageing and Retirement in Europe (SHARE) is a multidisciplinary and cross-national panel database of micro data on health, socio-economic status and social and family networks of about 140,000 individuals aged 50 or older (around 380,000 interviews). SHARE covers 27 European countries and Israel. SHARE data are available to the entire research community free of charge At the european level, SHARE survey is managed by Munich Economics of Ageing (Max-Planck Institute for social law and social policy, Munich, Germany) and funded by national public organisms at the country level. SHARE website : http://www.share-project.org/
Fe(III)-Catalyzed Cycloaddition Reaction of In Situ Formed Imines With Cyclic Enol Ethers
Creators: name: Behbahani, Farahnaz Kargar
name: Ziaei, Parisa
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Plasma Physics
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Microbiology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Fe(ClO4)3 and silica gel adsorbed Fe(ClO4)3 are reported as catalysts for [4+2] cycloaddition reactions of imines (formed in situ from anilines and enol ethers) with cyclic enol ethers to afford the corresponding pyrano- and furano[3,2-c]quinolines in good to excellent yields. Also, the catalytic activity of Fe(ClO4)3 in different solvents was compared with the other iron catalysts such as FePO4, Fe2(SO4)3.XH2O, (NH4)Fe(SO4)2.12H2O, Fe(acac)3, Fe(DS)3, Fe(OH)3, FeCl3.6H2O, and Fe(NO3)3.9H2O.
Wax worm assay for select agent bacteria
Creators: name: Fisher, Nathan
Publisher: name: figshare
Year: 2014
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This was an internal funding proposal submitted to the USAMRIID In-House Laboratory Innovative Research program in 2009. It was ranked highly but not funded because I had another project that was funded this year (limit of one project per investigator).