Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review
Creators: name: Santos, Stéphanie Piacenti dos
name: Morissugui, Sabrina Sayuri
name: Martins, Ana Paula D’Alarme Gimenez
name: de Mendonça Fernandes, Glaucia Maria
name: Russo, Anelise
name: Galbiatti-Dias, Ana Lívia Silva
name: Castanhole-Nunes, Márcia Maria Urbanin
name: Francisco, José Luis Esteves
name: Pavarino, Érika Cristina
name: Goloni-Bertollo, Eny Maria
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: The study was conducted to evaluate the frequency of polymorphisms in <i>GSTM1</i> and <i>GSTT1</i> genes in patients with breast cancer compared with individuals without history of cancer, and the association of these polymorphisms with clinical/epidemiological parameters.There were evaluated 752 women (219 patients and 533 controls). Molecular analysis was performed by the Polymerase Chain Reaction (PCR). Statistical analysis was used multiple logistic regression and descriptive statistics.Age ≥ 50 years (OR = 3.22, 95% CI = 2.30–4.51, <i>p</i> p = 0.008) were associated to the development of breast cancer, while smoking and null genotypes <i>GSTM1</i> and <i>GSTT1</i> presented no association. <i>GSTM1</i> and <i>GSTT1</i> polymorphisms presented no relationship with the clinical and histopathological parameters or molecular subtypes of breast cancer. Ninety-two percent of tumours were invasive ductal, 66% were grade II, 65% were larger than 2 cm, the stages II (35.3%) and III (31.2%) were the most prevalent, and 47.7% were molecular subtype luminal B.Individuals aged ≥ 50 years and alcohol consumers have more chance to developing breast cancer. <i>GSTM1</i> and <i>GSTT1</i> polymorphisms are not associated to the risk of breast cancer. The study was conducted to evaluate the frequency of polymorphisms in <i>GSTM1</i> and <i>GSTT1</i> genes in patients with breast cancer compared with individuals without history of cancer, and the association of these polymorphisms with clinical/epidemiological parameters. There were evaluated 752 women (219 patients and 533 controls). Molecular analysis was performed by the Polymerase Chain Reaction (PCR). Statistical analysis was used multiple logistic regression and descriptive statistics. Age ≥ 50 years (OR = 3.22, 95% CI = 2.30–4.51, <i>p</i> p = 0.008) were associated to the development of breast cancer, while smoking and null genotypes <i>GSTM1</i> and <i>GSTT1</i> presented no association. <i>GSTM1</i> and <i>GSTT1</i> polymorphisms presented no relationship with the clinical and histopathological parameters or molecular subtypes of breast cancer. Ninety-two percent of tumours were invasive ductal, 66% were grade II, 65% were larger than 2 cm, the stages II (35.3%) and III (31.2%) were the most prevalent, and 47.7% were molecular subtype luminal B. Individuals aged ≥ 50 years and alcohol consumers have more chance to developing breast cancer. <i>GSTM1</i> and <i>GSTT1</i> polymorphisms are not associated to the risk of breast cancer.