cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comprehensive safety profile of dipeptidyl peptidase-4 inhibitors: a post-marketing study based on FAERS database using signal detection algorithms
Creators: name: Bansal, Dipika
name: Yoosuf, Beema T
name: Favas, Muhammed
name: Dutta, Pinaki
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) have acquired a foothold in managing type 2 diabetes mellitus, but few concerns have arisen regarding their overall safety profile. The aim of this study is to assess the potential risk of DPP-4 inhibitors by analyzing data from the FDA Adverse Event Reporting System (FAERS) database. This is a retrospective study which explored the FAERS database till March 2023 for the collection of safety reports. The disproportionality analysis was performed using signal detection algorithms (SDAs) incorporating frequentist-based data mining approach such as relative reporting ratio (RRR), reporting odds ratio (ROR) and proportional reporting ratio (PRR) with 95% confidence interval (CI). A total of 14,573 adverse event reports were reported in the FAERS public dashboard associated with all the included DPP-4 inhibitors. The computed PRR, ROR, and RRR indicated positive signals for DPP-4 inhibitors with cardiac failure, pancreatitis, pemphigoid, hypoglycemia, acute kidney injury and lactic acidosis. Saxagliptin showed a higher signal score for cardiac failure, while sitagliptin was more associated with pancreatitis. Moreover, alogliptin exhibited an elevated signal score associated with pancreatic carcinoma. Several significant disproportionality signals were observed with DPP-4 inhibitors. However, clinicians have to consider the comorbidities and concomitant drugs while prescribing these drugs.
Supplementary Table 1
Creators: name: Nascimento, Débora C
name: Costa Neto, João M
name: Solcà, Manuela S
name: Estrela-Lima, Alessandra
name: Barbosa, Vivian F
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Clinical and laboratory variables obtained in the initial evaluation of cats that were victims of trauma associated with or without death
Additional file 1 of Roles of follicle stimulating hormone and sphingosine 1-phosphate co-administered in the process in mouse ovarian vitrification and transplantation
Creators: name: Wang, Fei
name: Tian, Yuan
name: Huang, Liwen
name: Qin, Tian
name: Ma, Wenye
name: Pei, Chengbin
name: Xu, Bo
name: Han, Hang
name: Liu, Xinrui
name: Pan, Pengge
name: Yu, Xiaoli
name: Chang, Qin
name: Wang, Yanrong
name: Zhang, Shuya
name: Pei, Xiuying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 1
Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
Creators: name: Förster, Charlotte
name: Eichert, André
name: Oberthür, Dominik
name: Betzel, Christian
name: Geßner, Reinhard
name: Nitsche, Andreas
name: Fürste, Jens P.
Publisher: name: Robert Koch-Institut
Year: 2012
Subjects: subject: 610 Medizin

description: "Locked nucleic acids" (LNAs) belong to the backbone-modified nucleic acid family. The 2'-O,4'-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability. This renders LNAs powerful tools for diagnostic and therapeutic applications. RNA molecules maintain the overall canonical A-type conformation upon substitution of single or multiple residues/nucleotides by LNA monomers. The structures of "all" LNA homoduplexes, however, exhibit significant differences in their overall geometry, in particular a decreased twist, roll and propeller twist. This results in a widening of the major groove, a decrease in helical winding, and an enlarged helical pitch. Therefore, the LNA duplex structure can no longer be described as a canonical A-type RNA geometry but can rather be brought into proximity to other backbone-modified nucleic acids, like glycol nucleic acids or peptide nucleic acids. LNA-modified nucleic acids provide thus structural and functional features that may be successfully exploited for future application in biotechnology and drug discovery.
STUDENTS’ UNDERSTANDING OF MICHAELIS-MENTEN KINETICS AND ENZYME INHIBITION
Creators: name: Rodriguez, Jon-Marc G
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified
Other education not elsewhere classified
Higher education

description: Currently there is a need for research that explores students’ understanding of advanced topics in order to improve teaching and learning beyond the context of introductory-level courses. This work investigates students’ reasoning about graphs used in enzyme kinetics. Using semi-structured interviews and a think aloud-protocol, 14 second-year students enrolled in a biochemistry course were provided two graphs to prompt their reasoning, a typical Michaelis-Menten graph and a Michaelis-Menten graph involving enzyme inhibition. Student responses were coded using a combination of inductive and deductive analysis, influenced by the resource-based model of cognition. Results involve a discussion regarding how students utilized mathematical resources to reason about chemical kinetics and enzyme kinetics, such as engaging in the use of symbolic/graphical forms and focusing on surface-level features of the equations/graphs. This work also addresses student conceptions of the particulate-level mechanism associated with competitive, noncompetitive, and uncompetitive enzyme inhibition. Based on the findings of this study, suggestions are made regarding the teaching and learning of enzyme kinetics.
sj-pdf-1-pie-10.1177_09544089211022617 - Supplemental material for Minimizing the overall loss coefficient of flat plate solar collector using energy, entropy and exergy analysis
Creators: name: Sathyakala, Ponnusamy
name: Gangadharan, Sai Sundara Krishnan
name: Kalaiarasu, Balaji
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-1-pie-10.1177_09544089211022617 for Minimizing the overall loss coefficient of flat plate solar collector using energy, entropy and exergy analysis by Ponnusamy Sathyakala, Sai Sundara Krishnan Gangadharan and Balaji Kalaiarasu in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Risk factors for sporadic Yersinia enterocolitica infections, Germany 2009–2010
Creators: name: Rosner, Bettina
name: Stark, Klaus
name: Höhle, Michael
name: Werber, Dirk
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2011
Subjects: subject: Yersinia enterocolitica
subject: Infectious disease epidemiology
subject: zoonotic foodborne diseases
subject: 610 Medizin

description: Yersinia enterocolitica is an important cause of acute gastrointestinal disease and post-infectious complications. In Germany, incidence of reported yersiniosis is relatively high compared with other countries of the European Union. Children aged
Additional file 1 of Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
Creators: name: Xie, Xin
name: Zhang, Xiaomin
name: Li, Songze
name: Du, Wei
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Mental Health

description: Supplementary Material 1
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation
Creators: name: Gilsdorf, Andreas
name: Morgan, Dilys
name: Leitmeyer, Katrin
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2012
Subjects: subject: Viral haemorrhagic fever
subject: Lassa fever
subject: Ebola haemorrhagic fever
subject: Marburg haemorrhagic fever
subject: Passenger trace back
subject: Contact tracing
subject: Air travel
subject: 610 Medizin

description: Background: Travel from countries where viral haemorrhagic fevers (VHF) are endemic has increased significantly over the past decades. In several reported VHF events on airplanes, passenger trace back was initiated but the scale of the trace back differed considerably. The absence of guidance documents to help the decision on necessity and scale of the trace back contributed to this variation. This article outlines the recommendations of an expert panel on Lassa fever, Ebola and Marburg haemorrhagic fever to the wider scientific community in order to advise the relevant stakeholders in the decision and scale of a possible passenger trace back. Method: The evidence was collected through review of published literature and through the views of an expert panel. The guidance was agreed by consensus. Results: Only a few events of VHF cases during air travel are reported in literature, with no documented infection in followed up contacts, so that no evidence of transmission of VHF during air travel exists to date. Based on this and the expert opinion, it was recommended that passenger trace back was undertaken only if: the index case had symptoms during the flight; the flight was within 21 days after detection of the event; and for Lassa fever if exposure of body fluid has been reported. The trace back should only be done after confirmation of the index case. Passengers and crew with direct contact, seat neighbours (+/− 1 seat), crew and cleaning personal of the section of the index case should be included in the trace back. Conclusion: No evidence has been found for the transmission of VHF in airplanes. This information should be taken into account, when a trace back decision has to be taken, because such a measure produces an enormous work load. The procedure suggested by the expert group can guide decisions made in future events, where a patient with suspected VHF infection travelled on a plane. However, the actual decision on start and scale of a trace back always lies in the hands of the responsible people taking all relevant information into account.
God’s Preservationists: The Championing of Conformity in Interregnum England, 1649–1660
Creators: name: Lawlor, Padraig A
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Historical studies not elsewhere classified
British history
Christian studies
Religion, society and culture

description: This dissertation examines the preservation of the Church of England in Interregnum England. It incorporates a microhistorical analysis of parish life in four Puritanical counties located in East Anglia, namely Cambridgeshire, Norfolk, Suffolk, and Essex. In the current historiography on the Church of England, scholars of religious history have traditionally associated both Puritan and sectarian activity with the political upheaval, religious reform, and the collapse of cultural norms that accompanied the English Interregnum. Absent from this scholarship, however, are the voices and actions of those devoted parishioners who refused to abandon their parish church after its disestablishment in 1649. These followers, henceforth called “Conformists,” both fostered and maintained a shared cultural system that stabilized their communal interaction in a period exemplified by politico-religious chaos. In a period characterized by bloody conflicts, their instruments were not swords, but sermons. Thus, this project reveals that the perseverance of Conformists amid the persecution of Cromwellian England was not arbitrary, but a disciplined reaction in which spiritual guidance was actively sought and developed. Central to this response were the actions of sequestered Conformist ministers who guided their displaced congregations by administering forbidden sacraments and emboldening communal engagement.
Comparative hepatitis A seroepidemiology in 10 European countries
Creators: name: Kurkela, S.
name: Pebody, Richard
name: Kafatos, G.
name: Andrews, Nick
name: Barbara, C.
name: Bruzzone, B.
name: Butur, D.
name: Caplinskas, S.
name: Davidkin, I.
name: Hatzakis, Angelos
name: Hellenbrand, Wiebke
name: Hesketh, L. M.
name: Nardone, A.
name: Nemecek, V.
name: Pistol, A.
name: Sobotová, Z.
name: Vranckx, R.
name: Anastassopoulou, C. G.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2012
Subjects: subject: Adolescent
subject: Humans
subject: Female
subject: Male
subject: Middle Aged
subject: Prevalence
subject: Hepatitis A/epidemiology
subject: Incidence
subject: Child
subject: Adult
subject: Seroepidemiologic Studies
subject: Europe/epidemiology
subject: Infant
subject: Hepatitis A Antibodies/blood
subject: Age Factors
subject: Young Adult
subject: Child Preschool
subject: Health Policy
subject: Hepatitis A/immunology
subject: Hepatitis A/transmission
subject: Hepatitis A Virus Human/immunology
subject: 610 Medizin

description: The WHO recommends hepatitis A virus (HAV) immunization according to level of transmission and disease burden. We aimed to identify susceptible age groups by standardized serosurveys to inform HAV vaccination policy in participating countries: Belgium, Czech Republic, England, Finland, Germany, Italy, Lithuania, Malta, Romania, and Slovakia. Each country tested national serum banks (n = 1854-6748), collected during 1996-2004, for anti-HAV antibodies. Local laboratory results were standardized to common units. Forty-one per cent of those aged
sj-pdf-4-pie-10.1177_09544089211022617 - Supplemental material for Minimizing the overall loss coefficient of flat plate solar collector using energy, entropy and exergy analysis
Creators: name: Sathyakala, Ponnusamy
name: Gangadharan, Sai Sundara Krishnan
name: Kalaiarasu, Balaji
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-4-pie-10.1177_09544089211022617 for Minimizing the overall loss coefficient of flat plate solar collector using energy, entropy and exergy analysis by Ponnusamy Sathyakala, Sai Sundara Krishnan Gangadharan and Balaji Kalaiarasu in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Use of multilocus variable-number tandem repeat analysis (MLVA) in eight European countries, 2012
Creators: name: Lindstedt, Bjorn-Arne
name: Torpdahl, M.
name: Vergnaud, G.
name: Hello, Simon Le
name: Weill, F. X.
name: Tietze, Erhard
name: Malorny, Burkhard
name: Prendergast, D. M.
name: Ghallchóir, E. N.
name: Lista, R. F.
name: Schouls, L. M.
name: Söderlund, R.
name: Börjesson, S.
name: Åkerström, S.
Publisher: name: Robert Koch-Institut
Year: 2013
Subjects: subject: Humans
subject: Phylogeny
subject: Genotype
subject: Cluster Analysis
subject: Minisatellite Repeats
subject: Genetic Variation
subject: Europe
subject: DNA Bacterial/genetics
subject: Sequence Analysis DNA
subject: Electrophoresis Gel Pulsed-Field
subject: Multilocus Sequence Typing
subject: Gram-Negative Bacteria/classification
subject: Gram-Negative Bacteria/genetics
subject: Gram-Negative Bacteria/isolation & purification
subject: Gram-Positive Bacteria/classification
subject: Gram-Positive Bacteria/genetics
subject: Gram-Positive Bacteria/isolation & purification
subject: 610 Medizin

description: Genotyping of important medical or veterinary prokaryotes has become a very important tool during the last decades. Rapid development of fragment-separation and sequencing technologies has made many new genotyping strategies possible. Among these new methods is multilocus variable-number tandem repeat analysis (MLVA). Here we present an update on the use of MLVA in eight European countries (Denmark, France, Germany, Ireland, Italy, the Netherlands, Norway and Sweden). Researchers in Europe have been active in developing and implementing a large array of different assays. MLVA has been used as a typing tool in several contexts, from aiding in resolving outbreaks of food-borne bacteria to typing organisms that may pose a bioterrorist threat, as well as in scientific studies.
Opportunity for Whom? Sources of Integenerational Mobility in the U.S.
Creators: name: Smith, Timothy M
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Agricultural economics

description: Economists generally consider intergenerational economic mobility to be an important feature of market economies, as it allows people born into poverty to achieve a measure of prosperity in the presence of minimal government intervention or redistribution. The empirical literature on mobility in the U.S. has, however, found evidence that mobility is lower than previously thought, and scholars have responded by developing expansive literatures on many aspects of intergenerational mobility, including studies of its origins. In this dissertation, I contribute to this strand of the literature by reviewing recent trends in the literature, with a particular emphasis on studies aimed at explaining the sources of mobility, and then discussing three empirical studies into specific sources of mobility, using data organized at different geographic and temporal scales. These empirical chapters focus on the role of different aspects of childhood poverty in determining income rank in adulthood, modeling variation in racial mobility gaps across different kinds of communities and local economies, and measuring the relationship between trends in intergenerational mobility and the structural transformation of agriculture in the 20th century U.S..
Surface-associated motility, a common trait of clinical isolates of Acinetobacter baumannii, depends on 1,3-diaminopropane
Creators: name: Skiebe, Evelyn
name: Berardinis, Véronique De
name: Morczinek, Peter
name: Kerrinnes, Tobias
name: Faber, Franziska
name: Lepka, Daniela
name: Hammer, Bettina
name: Zimmermann, Ortrud
name: Ziesing, Stefan
name: Wichelhaus, Thomas A.
name: Hunfeld, Klaus-Peter
name: Borgmann, Stefan
name: Gröbner, Sabine
name: Higgins, Paul G.
name: Seifert, Harald
name: Busse, Hans-Jürgen
name: Witte, Wolfgang
name: Pfeifer, Yvonne
name: Wilharm, Gottfried
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2012
Subjects: subject: Acinetobacter baumannii
subject: Motility
subject: 1
subject: 3-Diaminopropane
subject: dat
subject: ddc
subject: Acinetobacter baylyi
subject: ADP1
subject: Galleria mellonella
subject: 610 Medizin

description: While flagella-independent motility has long been described in representatives of the genus Acinetobacter, the mechanism of motility remains ambiguous. Acinetobacter baumannii, a nosocomial pathogen appearing increasingly multidrug-resistant, may profit from motility during infection or while persisting in the hospital environment. However, data on the frequency of motility skills among clinical A. baumannii isolates is scarce. We have screened a collection of 83 clinical A. baumannii isolates of different origin and found that, with the exception of one isolate, all were motile on wet surfaces albeit to varying degrees and exhibiting differing morphologies. Screening a collection of transposon mutants of strain ATCC 17978 for motility defects, we identified 2 akinetic mutants carrying transposon insertions in the dat and ddc gene, respectively. These neighbouring genes contribute to synthesis of 1,3-diaminopropane (DAP), a polyamine ubiquitously produced in Acinetobacter. Supplementing semi-solid media with DAP cured the motility defect of both mutants. HPLC analyses confirmed that DAP synthesis was abolished in ddc and dat mutants of different A. baumannii isolates and was re-established after genetic complementation. Both, the dat and ddc mutant of ATCC 17978 were attenuated in the Galleria mellonella caterpillar infection model. Taken together, surface-associated motility is a common trait of clinical A. baumannii isolates that requires DAP and may play a role in its virulence.
Espacios de la memoria. Marcel Proust y Juan Benet
Creators: name: Díaz-Navarro, Epicteto
Publisher: name: Peter Lang
Year: 2010
Subjects: subject: Memory
subject: Comparative literature
subject: Twenty-first century
subject: Fiction

description: In recent years it has been recognized that Proust profoundly influences different Spanish narrators (see H. Craig, also for Latin American literature), and in this work it is shown how in the syntax, the type of narrator, the construction of the scene and other aspects in Juan Benet's narrative show the Prustian influence.
sj-docx-2-psp-10.1177_01461672211025945 – Supplemental material for Thanks, but No Thanks: Unpacking the Relationship Between Relative Power and Gratitude
Creators: name: Anicich, Eric M.
name: Lee, Alice J.
name: Liu, Shi
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-2-psp-10.1177_01461672211025945 for Thanks, but No Thanks: Unpacking the Relationship Between Relative Power and Gratitude by Eric M. Anicich, Alice J. Lee and Shi Liu in Personality and Social Psychology Bulletin
Supplemental Material, sj-docx-1-jmx-10.1177_00222429211000068 - Managing the Versioning Decision over an App’s Lifetime
Creators: name: Lee, Seoungwoo
name: Zhang, Jie
name: Wedel, Michel
Publisher: name: SAGE Journals
Year: 2021
Subjects: Hospitality Management

description: Supplemental Material, sj-docx-1-jmx-10.1177_00222429211000068 for Managing the Versioning Decision over an App’s Lifetime by Seoungwoo Lee, Jie Zhang and Michel Wedel in Journal of Marketing
Comparative evaluation of adverse drug reactions for tenofovir alafenamide and tenofovir disoproxil fumarate using the FAERS Database: a disproportionality analysis
Creators: name: Zhu, Meng
name: Jia, Lingjuan
name: Wang, Yike
name: Zhang, Yongsheng
name: Lv, Shengxia
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) are widely used nucleoside reverse transcriptase inhibitors (NRTIs), necessitating a thorough understanding of their safety profiles to ensure optimal patient care and treatment adherence. We employed statistical methods including the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-Item Gamma Poisson Shrinker (MGPS) to compare and evaluate the safety profiles of these NRTIs. TAF was significantly associated with weight increase (ROR: 6.43; 95% CI: 5.93–6.96) and specific psychiatric disorders. TDF showed a notable signal for renal disorders and product-related issues, including product dose omission (ROR: 3.53; 95% CI: 3.22–3.87). Additionally, the study highlighted differences in safety signals related to pregnancy outcomes, with TAF having a higher ROR for maternal exposure (ROR: 7.83; 95% CI: 7.06–8.69) and TDF for fetal exposure (ROR: 4.51; 95% CI: 3.93–5.18), underscoring the need for cautious use in pregnant women. The comparative analysis also identified signals for osteonecrosis (ROR: 108.81; 95% CI: 106.25–111.43) and bone loss (ROR: 714; 95% CI: 685.49–743.68) for TAF and TDF, respectively, highlighting the importance of bone health considerations in treatment plans. These findings underscore the importance of personalized antiviral therapy and patient safety.
sj-docx-1-msj-10.1177_13524585211030212 – Supplemental material for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study
Creators: name: Høgestøl, Einar August
name: Ghezzo, Samuele
name: Nygaard, Gro Owren
name: Espeseth, Thomas
name: Sowa, Piotr
name: Beyer, Mona K
name: Harbo, Hanne Flinstad
name: Westlye, Lars T
name: Hulst, Hanneke E
name: Alnæs, Dag
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-msj-10.1177_13524585211030212 for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study by Einar August Høgestøl, Samuele Ghezzo, Gro Owren Nygaard, Thomas Espeseth, Piotr Sowa, Mona K Beyer, Hanne Flinstad Harbo, Lars T Westlye, Hanneke E Hulst and Dag Alnæs in Multiple Sclerosis Journal
Reliability of case definitions for public health surveillance assessed by Round-Robin test methodology
Creators: name: Krause, Gérard
name: Brodhun, Bonita
name: Altmann, Doris
name: Claus, Hermann
name: Benzler, Justus
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2006
Subjects: subject: Humans
subject: Sensitivity and Specificity
subject: Multivariate Analysis
subject: Attitude of Health Personnel
subject: Communicable Diseases/classification
subject: Consensus
subject: Disease Notification/standards
subject: Germany/epidemiology
subject: Local Government
subject: Population Surveillance/methods
subject: Public Health Administration/standards
subject: Public Health Informatics/standards
subject: Software/standards
subject: State Government
subject: 610 Medizin

description: Background: Case definitions have been recognized to be important elements of public health surveillance systems. They are to assure comparability and consistency of surveillance data and have crucial impact on the sensitivity and the positive predictive value of a surveillance system. The reliability of case definitions has rarely been investigated systematically. Methods: We conducted a Round-Robin test by asking all 425 local health departments (LHD) and the 16 state health departments (SHD) in Germany to classify a selection of 68 case examples using case definitions. By multivariate analysis we investigated factors linked to classification agreement with a gold standard, which was defined by an expert panel. Results: A total of 7870 classifications were done by 396 LHD (93%) and all SHD. Reporting sensitivity was 90.0%, positive predictive value 76.6%. Polio case examples had the lowest reporting precision, salmonellosis case examples the highest (OR = 0.008; CI: 0.005–0.013). Case definitions with a check-list format of clinical criteria resulted in higher reporting precision than case definitions with a narrative description (OR = 3.08; CI: 2.47–3.83). Reporting precision was higher among SHD compared to LHD (OR = 1.52; CI: 1.14–2.02). Conclusion: Our findings led to a systematic revision of the German case definitions and build the basis for general recommendations for the creation of case definitions. These include, among others, that testable yes/no criteria in a check-list format is likely to improve reliability, and that software used for data transmission should be designed in strict accordance with the case definitions. The findings of this study are largely applicable to case definitions in many other countries or international networks as they share the same structural and editorial characteristics of the case definitions evaluated in this study before their revision.
Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters
Creators: name: Kratzel, Christine
name: Mai, Jessica
name: Madela, Kazimierz
name: Beekes, Michael
name: Krüger, Dominique
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2006
Subjects: subject: Animals
subject: Female
subject: Male
subject: Cricetinae
subject: Mesocricetus
subject: Foot
subject: Nitriles/toxicity
subject: Sciatic Nerve/drug effects
subject: Sciatic Nerve/virology
subject: Scrapie/metabolism
subject: 610 Medizin

description: As is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) and leading to a fatal end of the disease. The lack of therapeutic approaches for TSE is partially due to the limited amount of information available on the involvement of host biological compartments and processes in the propagation of the infectious agent. The in vivo model presented here can provide information on the spread of the scrapie agent via the peripheral nerves of hamsters under normal and altered axonal conditions. Syrian hamsters were unilaterally footpad (f.p.) infected with scrapie. The results of the spatiotemporal ultrasensitive immunoblot-detection of scrapie-associated prion protein (PrPSc) in serial nerve segments of both distal sciatic nerves could be interpreted as a centripetal and subsequent centrifugal neural spread of PrPSc for this route of infection. In order to determine whether this propagation is dependent on main components in the axonal cytoskeleton (e.g. neurofilaments, also relevant for the component ‘a’ of slow axonal transport mechanisms), hamsters were treated -in an additional experiment- with the neurotoxin ß,ß’-iminodiproprionitrile (IDPN) around the beginning of the scrapie infection. A comparison of the Western blot signals of PrPSc in the ipsilateral and in the subsequently affected contralateral sciatic nerve segments with the results revealed from IDPN-untreated animals at preclinical and clinical stages of the TSE disease, indicated similar amounts of PrPSc. Furthermore, the mean survival time was unchanged in both groups. This in vivo model, therefore, suggests that the propagation of PrPSc along peripheral nerves is not dependent on an intact neurofilament component of the axonal cytoskeleton. Additionally, the model indicates that the spread of PrPSc is not mediated by the slow component ‘a’ of the axonal transport mechanism.
Additional file 1 of Ultrasensitive and visual detection of Feline herpesvirus type-1 and Feline calicivirus using one-tube dRPA-Cas12a/Cas13a assay
Creators: name: Jiang, Fumei
name: Liu, Yunjia
name: Yang, Xiaonong
name: Li, Yan
name: Huang, Jian
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 1
sj-pdf-1-ajs-10.1177_03635465211008655 – Supplemental material for The Beneficial Effect of an Intra-articular Injection of Losartan on Microfracture-Mediated Cartilage Repair Is Dose Dependent
Creators: name: Logan, Catherine A.
name: Gao, Xueqin
name: Utsunomiya, Hajime
name: Scibetta, Alex C.
name: Talwar, Mika
name: Ravuri, Sudheer K.
name: Ruzbarsky, Joseph J.
name: Arner, Justin W.
name: Zhu, Dandan
name: Lowe, Walter R.
name: Philippon, Marc J.
name: Huard, Johnny
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211008655 for The Beneficial Effect of an Intra-articular Injection of Losartan on Microfracture-Mediated Cartilage Repair Is Dose Dependent by Catherine A. Logan, Xueqin Gao, Hajime Utsunomiya, Alex C. Scibetta, Mika Talwar, Sudheer K. Ravuri, Joseph J. Ruzbarsky, Justin W. Arner, Dandan Zhu, Walter R. Lowe, Marc J. Philippon and Johnny Huard in The American Journal of Sports Medicine
Analysis of adverse events induced by fluconazole based on FAERS database
Creators: name: Su, Tang
name: Jianglin, Li
name: Si, Su
name: Xin, Liu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Fluconazole, a widely used antifungal agent, has been associated with various adverse events (AEs). This study aimed to analyze the safety profiles of fluconazole using the FDA Adverse Event Reporting System (FAERS) database to provide insights for its safe use. Fluconazole-related AEs from 2004 to 2024Q2 were extracted from the FAERS database. The Reporting Odds Ratio (ROR) method was employed to detect and analyze safety signals. Additionally, the impact of COVID-19 on fluconazole safety was also examined. A total of 7,720 AEs were identified, with 40.3% being serious. The most common AEs involved skin, gastrointestinal, and administration site reactions. High doses of fluconazole were linked to increased teratogenic risks. Weekly dosing regimens and doses below 200 mg/day were associated with fewer severe AEs. During the COVID-19 pandemic, there was a notable rise in reports of drug inefficacy and hepatic/renal damage. Additionally, 45 new adverse reactions were identified. The study highlights the importance of monitoring liver, kidney, and cardiovascular functions during fluconazole use, especially in high-risk populations. The findings underscore the need for careful dosing and consideration of drug interactions, particularly during the COVID-19 pandemic, to ensure safe and effective use of fluconazole.
Numerical Simulation for torsional strengths for Helical hollow strand tube products
Creators: name: Devpalli, Dilipkumar Umeshbhai
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Biomedical instrumentation
Mechanical engineering not elsewhere classified

description: Due to reduced pain, shortened hospital stay and recovery, minimally invasive surgery (MIS) is becoming more and more popular in healthcare systems. MIS requires some devices for the motion and force transformation from outside to the inside of the body of a patient, and the strangled cables play a significant role in developing the instrumentations to serve for such purposes. However, current design and selection of a strangled cable is mostly intuitive that depend greatly on designers’ experiences and availability of experimental data, which leads to non-optimized designs and longer design cycles. In this thesis, both of analytical modelling and numerical simulation are proposed to build the relation of applied torque and deflection of part, so that a strangled cable with a given configuration can be characterized in term of its load-deflection relation. The defined relation has its great significance and application potential in the design optimization and precise controls of medical devices for MISs.Besides the various patterns of strangled cables, a Helical hollow strand (HHS®) tube is a special type of strangled cables with single- or multiple- layer configurations., In each layer, each of the helical wires touches its two neighboring helical wires, and it has a coreless hollow at the center. Its primary application is to carry a torsional load in a twisting mode. As an extreme, there is a possibility that all helical wires touch each other, and this forms a statically indeterminate contact obstacle in design analysis. Numerical simulation would predict that contacts occur simultaneously at all possible contacting points under the circumference that the strand is fixed at one end against rotation. In addition, the friction at contacts will affect the torsional deformation; therefore, these contacts must be taken into consideration in the development of analytical and numerical simulation models.This thesis reports the results of the investigation on the characteristics of Helical hollow strand tube (HHS®), more specifically, the relation of torsional deflection and the applied torque over a tube in the clockwise (CW) direction. The numerical simulation approach to predict the torsional deflection of HHS with various design parameters and configurations is emphasized.
sj-pdf-1-trr-10.1177_03611981211025279 – Supplemental material for Travel Mode Choices in a Greening Market: The Impact of Electric Vehicles and Prior Investments
Creators: name: van Dijk, Jeremy
name: Farsi, Mehdi
name: Weber, Sylvain
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-1-trr-10.1177_03611981211025279 for Travel Mode Choices in a Greening Market: The Impact of Electric Vehicles and Prior Investments by Jeremy van Dijk, Mehdi Farsi and Sylvain Weber in Transportation Research Record
Behavioral Factor in the Decision Making of Professional Fund Manager
Creators: name: Shivani Faujdaar
Publisher: name: Zenodo
Year: 2024

description: Behavioural factors play a crucial role in the decision-making process of professional fund managers. Professional fund managers make decisions influenced by various factors, and behavioural factors play a significant role in their decision-making process. These factors encompass various psychological biases and emotional influences that can impact their investment choices. Understanding these behavioural tendencies is essential for comprehending why certain investment decisions are made and their subsequent outcomes in financial markets. By examining how cognitive biases, risk perceptions, and emotional responses influence fund managers, we gain insight into the complexities of investment decision-making and its implications for portfolio performance.
Supplemental Material, sj-pdf-1-cob-10.1177_26335565211032880 - The incidence of multimorbidity and patterns in accumulation of chronic conditions: A systematic review
Creators: name: Kudesia, Prtha
name: Salimarouny, Banafsheh
name: Stanley, Meagan
name: Fortin, Martin
name: Stewart, Moira
name: Terry, Amanda
name: Ryan, Bridget L
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental Material, sj-pdf-1-cob-10.1177_26335565211032880 for The incidence of multimorbidity and patterns in accumulation of chronic conditions: A systematic review by Prtha Kudesia, Banafsheh Salimarouny, Meagan Stanley, Martin Fortin, Moira Stewart, Amanda Terry and Bridget L Ryan in Journal of Comorbidity
Additional file 2 of Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study
Creators: name: Lee, Jun-Hyuk
name: Kwon, Yu-Jin
name: Kim, Sung Jin
name: Joung, Boyoung
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Additional file 2: Table S1. Weighted logistic regression analysis for the risk of normal tension glaucoma and POAG with ocular hypertension according to the presence of metabolic syndrome. Table S2. Weighted logistic regression analysis for ocular hypertension according to the presence of metabolic syndrome. Table S3. Weighted logistic regression analysis for ocular hypertension risk by incremental number of metabolic syndrome components.
Establishing Outcome Parameters for Helicopter Emergency Medical Services Research in The Netherlands: Results of a Mixed-Methods Delphi Consensus Study
Creators: name: Vianen, Niek J.
name: Campfens, J. Reinout
name: Brouwer-Bergsma, Margot
name: Van Ditshuizen, Jan C.
name: Giannakopoulos, Georgios F.
name: Hoogerwerf, Nico
name: Hartog, Dennis den
name: Van Lieshout, Esther M. M.
name: Maissan, Iscander M.
name: Schober, Patrick
name: Venema, Lieneke
name: Verhofstad, Michael H. J.
name: Van Vledder, Mark G.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Physician staffed Helicopter Emergency Medical Services (P-HEMS) care in the Netherlands has transitioned from predominantly trauma management to handling a variety of medical conditions. Relevant outcome parameters for Dutch P-HEMS research have not been previously defined. National consensus was sought to identify relevant long term patient outcome parameters, process outcome parameters and performance outcome parameters for Dutch P-HEMS care. This was a mixed methods Delphi consensus study. A list of potentially relevant outcome parameters was identified using a systematic literature review. These parameters were subsequently surveyed in a Delphi consensus study. Helicopter Emergency Medical Services physicians and relevant stakeholders were invited to participate in this Delphi survey, where they were allowed to suggest additional outcome parameters. Descriptive analysis was performed on all data sets. Forty-nine potential outcome parameters for Dutch P-HEMS care were surveyed. Of 71 invited participants, 53 (75%), 40 (56%), and 20 (28%) participated in the first, second, and third round of the Delphi study, respectively. Consensus was reached on 25 (51%) of 49 outcome parameters as being important. These consisted of seven long term patient related outcome parameters, four short term patient related outcome parameters, five process outcome parameters and nine performance outcome parameters. In conclusion, this study identified 25 outcome parameters relevant for Dutch physician staffed HEMS care. These parameters should be considered when designing future studies and should be routinely collected for each dispatch if possible.
“Giving a Face to the Silenced Victims: Recent Documentaries on Gaza”
Creators: name: A.M. Nashef, Hania
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Middle East--Palestine
subject: Area studies
subject: Motion pictures
subject: Arabs--Social life and customs

description: Often described as an open-air prison, the citizens of the Gaza Strip have long resisted a subaltern existence.  Conditions in Gaza, and specifically since the Second Intifada of 2000, have increasingly worsened.  With the advent of Hamas in 2006-2007, a complete blockade was imposed on the Strip.  A deafening silence by the world has resulted in a marked increase in documentaries from within and has also attracted international filmmakers who want to tell the Gazan story. In these productions, Gazans convey their stories to the outside world and demand that their humanity is acknowledged. My analysis of a number of recent documentaries demonstrates how Gazans emphatically reject the role of victim but rather want to tell their stories and to be heard directly. They want to be tellers of their stories.  Despite their misfortunes, Gazans remain resilient, aspiring for life. This need has become more urgent since the 2014 war.  The documentaries, I discuss, include Gaza (2019) by Garry Keane and Andrew McConnell, Killing Gaza (2018) by Dan Cohen and Max Blumenthal, Ambulance (2016) by Mohamed Jabaly, Born in Gaza (2014) by Argentinian director Hernán Zin, Nitin Sawhney’s Flying Paper (2014), and Fida Qishta’s Where Should the Birds Fly (2013).
Stereocilia Morphogenesis and Maintenance is dependent on the Dynamics of Actin Cytoskeletal Proteins
Creators: name: Roy, Pallabi
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: Age-related hearing loss is an acute health problem affecting people worldwide, often arising due to defects in the proper functioning of sensory hair cells in the inner ear. The apical surface of sensory hair cells contains actin-based protrusions known as stereocilia, which detect sound and head movements. Since hair cells are not regenerated in mammals, it is important to maintain the functioning of stereocilia for the life of an organism to maintain hearing ability. The actin filaments within a stereocilium are extensively crosslinked by various actin crosslinking proteins, which are important for stereocilia development and maintenance. Multiple studies have shown that the stereocilia actin core is exceptionally stable whereas actin is dynamic only at the tips of stereocilia. However, whether the actin crosslinking proteins, which are nearly as abundant as actin itself, are similarly stable or can freely move in and out of the core remains unknown. Loss or mutation of crosslinkers like plastin-1, fascin-2, and XIRP2 causes progressive hearing loss along with stereocilia degeneration while loss of espin prevents stereocilia from even developing properly. Do these phenotypes stem from an unstable stereocilia core? Does crosslinking confer stability to the core? To address these questions, we generated novel transgenic reporter lines to monitor the dynamics of actin in mice carrying fascin-2R109H mutation and espin null mice and also to study the dynamics of actin crosslinkers, in vivo and ex-vivo. We established that actin crosslinkers readily exchange within the highly stable F-actin structure of the stereocilia core. In addition, we determined that stereocilia degeneration in mice carrying fascin-2R109H mutation and espin null mice could possibly occur due to a less stable actin core. These studies suggest that dynamic crosslinks stabilize the core to maintain proper stereocilia functioning. Future work warrants understanding the reason behind the importance of dynamic crosslinks within a stable stereocilia core. Actin stability not only depends on actin crosslinkers, but also on actin filament composition as evident from distinct stereocilia degeneration and progressive hearing loss patterns in hair-cell specific knockout of actin isoforms. Although beta- and gamma- actin polypeptide sequences differ by only 14 four amino acids, whether the latter determine the unique function of each cytoplasmic actin isoform was previously unknown. Here we determined that these four critical amino acids determine the unique functional importance of beta-actin isoform in sensory hair cells. Taken together, our study demonstrates that actin cytoskeletal proteins are important for the morphogenesis and maintenance of stereocilia.