cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
L’insostenibile leggerezza della laicità italiana
Creators: name: Fiorita, Nicola
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Testo, con la sola aggiunta delle note essenziali, della relazione svolta nella giornata di studio su “La laicità e gli ordinamenti giuridici: principi, valori e regole”, organizzata dall’Università della Calabria in data 5 maggio 2011. Il testo è destinato alla pubblicazione sulla Rivista Diritto e religioni.
description: Stato, Chiese e pluralismo confessionale, 2011: 13 giugno
On adaptive random testing
Creators: name: Kuo, Fei-Ching
Publisher: name: Swinburne
Year: 2024

description: Adaptive random testing (ART) has been proposed as an enhancement to random testing for situations where failure-causing inputs are clustered together. The basic idea of ART is to evenly spread test cases throughout the input domain. It has been shown by simulations and empirical analysis that ART frequently outperforms random testing. However, there are some outstanding issues on the cost-effectiveness and practicality of ART, which are the main foci of this thesis. Firstly, this thesis examines the basic factors that have an impact on the faultdetection effectiveness of adaptive random testing, and identifies favourable and unfavourable conditions for ART. Our study concludes that favourable conditions for ART occur more frequently than unfavourable conditions. Secondly, since all previous studies allow duplicate test cases, there has been a concern whether adaptive random testing performs better than random testing because ART uses fewer duplicate test cases. This thesis confirms that it is the even spread rather than less duplication of test cases which makes ART perform better than RT. Given that the even spread is the main pillar of the success of ART, an investigation has been conducted to study the relevance and appropriateness of several existing metrics of even spreading. Thirdly, the practicality of ART has been challenged for nonnumeric or high dimensional input domains. This thesis provides solutions that address these concerns. Finally, a new problem solving technique, namely, mirroring, has been developed. The integration of mirroring with adaptive random testing has been empirically shown to significantly increase the cost-effectiveness of ART. In summary, this thesis significantly contributes to both the foundation and the practical applications of adaptive random testing.
Scoping Review of Symptoms in Children with Rare, Progressive, Life-Threatening Disorders
Creators: name: Pawliuk, Colleen
name: Widger, Kimberley
name: Dewan, Tammie Joanne
name: Brander, Gina
name: Brown, Helen
name: Hermansen, Anne-Mette
name: Grégoire, Marie-Claude
name: Steele, Rose
name: Siden, Harold
Publisher: name: The University of British Columbia
Year: 2020

description: Background: Q3 conditions are progressive, metabolic, neurological, or chromosomal childhood conditions without a cure. Children with these conditions face an unknown lifespan as well as unstable and uncomfortable symptoms. Clinicians and other health care professionals are challenged by a lack of evidence for symptom management for these conditions. Aims: In this scoping review we systematically identified and mapped the existing literature on symptom management for children with Q3 conditions. We focussed on the most common and distressing symptoms, namely alertness, behavioral problems, bowel incontinence, breathing difficulties, constipation, feeding difficulties, sleep disturbance, temperature regulation, tone and motor problems and urinary incontinence. For children with complex health conditions, good symptom management is pertinent to ensure the highest possible quality of life. Methods: Scoping Review. Electronic database searches in Ovid MEDLINE, Embase and CINAHL and a comprehensive grey literature search. Results: We included 292 studies in our final synthesis. The most commonly reported conditions in the studies were Rett syndrome (n=69), followed by De Lange syndrome (n=25) and tuberous sclerosis (n=16). Tone and motor problems was the most commonly investigated symptom (n=141), followed by behavioral problems (n=82) and sleep disturbance (n=71). Conclusion: The evidence for symptom management in Q3 conditions is concentrated around a few conditions and these studies may not be applicable to other conditions. The evidence is dispersed in the literature and difficult to access, which further challenges health care providers. More research needs to be done in these conditions to provide high quality evidence for the care of these children.
Problemi e modelli di libertà religiosa individuale e collettiva nell’Est Europa: contributo a un nuovo diritto ecclesiastico per l’Unione Europea
Creators: name: Cimbalo, Giovanni
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Contributo destinato alla pubblicazione negli Scritti in onore di Giovanni Barberini,
in corso di stampa.SOMMARIO: 1. Le nuove prospettive del diritto ecclesiastico - 2. Dall’Est il
recupero dell’integrità della memoria - 3. Problemi specifici delle grandi famiglie
religiose dell’Est nei rapporti con lo Stato - 4. La tutela individuale della libertà
religiosa e di coscienza.
description: Stato, Chiese e pluralismo confessionale, 2008: 3 novembre
La laicità contesa. Aspetti della crisi politica turca
Creators: name: Prandi, Matteo
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Il contributo è segnalato dal Prof. Giuseppe Casuscelli.SOMMARIO: 1. Introduzione – 2. Per una prima ricostruzione fattuale della crisipolitica turca nel biennio 2007-2008 – 3. Il giudizio sullo scioglimento del partitoAKP: le argomentazioni delle parti – 4. La sentenza della Corte costituzionale del 30luglio 2008. La Corte tra funzione di equilibrio e difesa del laicismo – 5. Cenniconclusivi, nella prospettiva del diritto ecclesiastico europeo.
description: Stato, Chiese e pluralismo confessionale, 2008: 3 novembre
Libertà religiosa e autonomia confessionale
Creators: name: Cardia, Carlo
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Relazione Convegno di Lugano - 3 novembre 2008SOMMARIO: 1. Normativa internazionale, libertà religiosa, autonomiaistituzionale delle confessioni religiose - 2. Modernità e libertà religiosa. Crollo deltotalitarismo e tramonto del giurisdizionalismo nei rapporti con le Chiese - 3.Forme residue di giurisdizionalismo benevolo. Organismi confessionali creati perlegge statale e condizionamento delle Chiese - 4. Segue. Finanziamento pubblicodelle Chiese, incidenza sulla libertà dei fedeli e sulla autonomia confessionale - 5.Conclusioni. Prospettive riformatrici, diritti dello Stato, diritti delle Chiese.
description: Stato, Chiese e pluralismo confessionale, 2008: 10 novembre
Spectral evolution of the peculiar Ic supernova 1998bw
Creators: name: Stathakis, R. A.
name: Boyle, B. J.
name: Jones, D. H.
name: Bessell, M. S.
name: Galama, T. J.
name: Germany, L. M.
name: Hartley, M.
name: James, D. M.
name: Kouveliotou, C.
name: Lewis, I. J.
name: Parker, Q. A.
name: Russell, K. S.
name: Sadler, E. M.
name: Tinney, C. G.
name: Van Paradijs, J.
name: Vreeswijk, P. M.
Publisher: name: Swinburne
Year: 2024

description: Supernova 1998bw holds the record for the most energetic Type Ic explosion, one of the brightest radio supernovae and probably the first supernova associated with a y-ray burst. In this paper we present spectral observations of SN 1998bw observed in a cooperative monitoring campaign using the Anglo-Australian Telescope, the UK Schmidt Telescope and the Siding Springs Observatories 2.3-m telescope. We investigate the evolution of the spectrum between 7 and 94 d after V-band maximum in comparison with well-studied examples of Type Ic SNe in order to quantify the unusual properties of this supernova event. Though the early spectra differ greatly from observations of classical Ic supernovae (SNe), we find that the evolution from the photospheric to nebular phases is slow but otherwise typical. The spectra differ predominantly in the extensive line blending and blanketing which has been attributed to the high velocity of the ejecta. We find that by day 19, the absorption line minima blueshifts are 10-50 per cent higher than other SNe and on day 94 emission lines are 45 per cent broader, as expected if the progenitor had a massive envelope. However, it is difficult to explain the extent of line blanketing entirely by line broadening, and we argue that an additional contribution from other species is present, indicating unusual relative abundances or physical conditions in the envelope.
The exploration of learning in Second Life : a focused ethnographic study in undergraduate nursing
Creators: name: Irwin, Pauletta Marie
Publisher: name: Southern Cross University
Year: 2020
Subjects: Avatar
Ecology of learning
Educational technology
Focused ethnography
Immersive learning
Inworld
Learning
Qualitative research
Second Life
Simulation
Technology
Tertiary education
Undergraduate nurse
University education
Virtual simulation
Virtual worlds

description: This thesis presents an understanding of the nature of learning in the online environment of Second Life (SL). The research adopts a qualitative approach, and utilises focused ethnography. Within the setting of a tri-campus tertiary education institute, the experiences of the participants were captured through observation, interviews and the collection of artefacts. The participants were undergraduate nurses, academics and Registered Nurses. Significant and unique findings demonstrate that learning in SL can enable the sequential development of experiential skills in a safe environment where peer and learning relationships flourish. Further research will examine if self-created avatar has an impact upon the learning experience
Semantic Network Service - Relaunch after 15 Years
Creators: name: Fock, Joachim
name: Bandholtz, Thomas
name: Jansing, Marc
Publisher: name: My University
Year: 2016
Subjects: Dienstleistung
Internet
Metainformation
Terminologie
Thesaurus
Umweltbundesamt
Umweltinformation

description: Im Juni dieses Jahres (2016) startete das Umweltbundesamt den Semantic Network Service (SNS https://sns.uba.de) neu, ein Dienstprogramm für Beschlagwortung von Texten und Suchunterstützung (Retrieval). Die SNS-Entwicklung begann vor 15 Jahren, um die Umweltterminologie (Umweltthesaurus UMTHES) im Web zugänglich zu machen, die von öffentlichen Informationssystemen genutzt werden kann. Warum jetzt ein Relaunch? Es gibt zwei Hauptgründe: Änderungen der Indexierungsanwendungsmuster und Entwicklung von Technologie und Standards. Wir konzentrieren uns im Beitrag auf Erfahrungen rund um SNS und seine Terminologie, und beschreiben dann kurz die neue Technologie und Standards.
description: In June this year (2016) the German Environment Agency relaunched the Semantic Network Service (SNS https://sns.uba.de), a utility for indexing and retrieval. The SNS development started 15 years ago for making the environmental terminology available on the Web to be used by public information systems. Why now a relaunch? There are two major reasons: changes in indexing application patterns; development of technology and standards. We will focus on such experiences around SNS and its terminology, and then shortly describe the new technology and standards.
Economic outcomes of female immigrant entrepreneurship
Creators: name: Low, Angeline
Publisher: name: Swinburne
Year: 2024

description: The contribution of female immigrant entrepreneurs is not acknowledged in the debates about the economic impact of Australian immigration. Often, the immigration debate is controversial and evolves around the questions, such as: What contributions do immigrants make? Do they add to or take from the country in net economic terms? Do immigrants take jobs from non-immigrants? Do immigrants create jobs? Do immigrants have higher unemployment rates than non-immigrants? Unfortunately, such debates attract anti-immigration views such as: immigrants are highly welfare-dependent and are welfare cheats; immigrants avoid paying taxes; immigrants employ their own kind and harbour other illegal immigrants; immigrants operate in the black economy; immigrants commit crimes; and many other negative expressions that add to the paranoia against immigrants and immigration policies. This paper is interested in engaging in the immigration debate by questioning the economic contributions of a group of Asian-born women entrepreneurs in Sydney. This empirical study shows that they make significant economic contributions to new businesses and to job creation in addition to other non-quantifiable economic benefits to Australia.
title: Empfehlungen für die Erstellung von Hitzeaktionsplänen - Handeln für eine bessere Gesundheitsvorsorge
title: Empfehlungen für die Erstellung von Hitzeaktionsplänen - Handeln für eine bessere Gesundheitsvorsorge
titleType: AlternativeTitle
Creators: name: Mücke, Hans-Guido
name: Straff, Wolfgang
Publisher: name: My University
Year: 2020
Subjects: Gesundheit
Anpassung an den Klimawandel
Klimaänderung
Anpassung

description: Als Effekt des Klimawandels stellen extreme Hitzeereignisse eine zunehmende Gesundheitsgefährdung dar. Hitzeaktionspläne dienen der Etablierung gezielter Interventionsmaßnahmen zum präventiven Gesundheitsschutz. Hierzu wurden 2017 Handlungsempfehlungen publiziert. Sie skizzieren kurz-, mittel- und langfristige Optionen für gesundheitliche Anpassungsmaßnahmen an den Klimawandel für eine zeitnahe Umsetzung regional bzw. lokal angepasster Hitzeaktionspläne. Quelle: https://www.degruyter.com
I reati culturalmente motivati: la cultural defense in alcune sentenze statunitensi
Creators: name: Sorio, Carlo
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Il contributo è segnalato dal Prof. Fabio Basile.SOMMARIO: 1. Cenni preliminari sulla c.d.cultural defense - 2. Sentenze in cui sidà rilievo allacultural defense - 2.1. Assoluzione - 2.1.1. People v. Metallides (1974) -2.1.2. State v. Kargar (1993) - 2.1.3. State v. Krasniqi (1989-1992) - 2.2. Derubricazionedel reato e/o riduzione della pena - 2.2.1. People v. Kimura (1975) - 2.2.2. People v.Poddar (1969-1974) - 2.2.3. People v. Moua (1985) - 2.2.4. People v. Chen (1987) - 3.Sentenze in cui si nega rilievo allacultural defense - 3.1. People v. Romero (1999) -3.2. People v. Rhines (1982) - 3.3. People v. Aphaylath (1986) - 3.4. Siripongs v.Calderon (1994) - 4. Riflessioni conclusive.
description: Stato, Chiese e pluralismo confessionale, 2008: 10 novembre
Social characteristics facilitating entrepreneurship
Creators: name: Dabic, Marina
name: Kovac, Ivana
name: Novak, Ivan
Publisher: name: Swinburne
Year: 2024

description: Paper aims to explore characteristics of students needed to be fostered for development of future entrepreneurs. The emphasis is on the educational part of the entrepreneurial carrier. It is discussed what is expected from the educational system concerning the preparation of the future graduates that will decide to follow up their business ideas and dear to test their strength on the market. Significant connection was found in all categories believed to be characteristics of the entrepreneurs and the measured intention itself. Additional results confirmed the relationship linking the entrepreneurial intention and demand for this type of education. Sample size is 403 graduate students from the Republic of Croatia.
Behaviour of square high-strength concrete columns under load reversals.
Creators: name: Lipien, Wojciech.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Engineering, Civil.

description: Strength and deformation characteristics of 10 square confined high-strength concrete columns were investigated. Properties of columns were selected to allow assessment of the importance of confinement parameters for high-strength concrete columns. The specimens were tested under constant axial compression and incrementally increasing lateral deformation reversals, simulating seismic action. The data indicate that high-strength concrete columns can be confined to behave in a ductile manner. The volumetric ratio of confinement reinforcement required for high strength concrete columns is higher than that required for normal-strength concrete columns, although the spacing requirement does not appear to be a function of concrete strength. Columns confined with higher grade lateral reinforcement require lower volumetric ratios of confinement steel. The arrangement of lateral reinforcement plays an important role on improving deformability. Columns confined with well-distributed longitudinal reinforcement, laterally supported by transverse reinforcement show improved deformability. The volumetric ratio and spacing limitations for these columns need not be as stringent as those required for less favourable steel arrangements. Axial compression reduces column ductility. An analytical investigation was also conducted to assess the applicability of conventional analyses techniques used for normal-strength concrete columns to those made with high-strength concrete. The applicability of a confinement model, based on test data under concentric compression, was verified against experimental data. The results indicate that the confinement model can be employed to columns under combined bending and axial load. Furthermore, moment-curvature relationships obtained by plane section analysis, moment-rotation and force-displacement relationships obtained by integration of curvatures and consideration of column plastic hinging region, as usually done for columns with normal-strength concrete, produce fairly accurate representation of experimentally observed force-deformation relationships. (Abstract shortened by UMI.)
Supply Chain Management in Humanitarian Aid and Disaster Relief
Creators: name: Liu, Mingli
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Supply chain management
Humanitarian aid and disaster relief
Conceptual framework formulation
Inventory prepositioning
Transportation planning
Linear optimization models ev
Charlottetown
Canadian coastal communities

description: Humanitarian aid and disaster relief are delivered in times of crises or natural disasters, such as after a conflict or in response to a hurricane, typhoon, or tsunami. Different from regular aid programs, aid and relief are provided to deal with emergency and immediate local areas, and to shelter affected people and refugees impacted by sudden traumatic events. There is evidence that natural and man-made disasters are increasing in numbers all around the world, affecting hundreds of millions of people every year. In spite of this fact, only in recent years – beginning in 2005 – has management of the supply chain of resources and materials for humanitarian aid and disaster relief been a topic of interest for researchers. Consequently, the academic literature in this field is comparatively new and still sparse, indicating a requirement for more academic studies. As a key part of the C-Change International Community-University Research Alliance (ICURA) project for managing adaptation to environmental change in coastal communities of Canada and the Caribbean, this thesis develops a framework and analytical model for domestic supply chain management in humanitarian aid and disaster relief in the event of severe storm and flooding in the Canadian C-Change community of Charlottetown, Prince Edward Island. In particular, the focus includes quantitative modeling of two specific aspects during the preparedness phase for emergency management: (1) inventory prepositioning and (2) transportation planning. In addition, this thesis proposes and analyses the characteristics of an effective supply chain management framework in practice to assist Canadian coastal communities in improving their preparation and performance in disaster relief efforts. The results indicate Charlottetown system effectiveness and decreased time to assist affected people are improved by distributing central emergency supply among more than one base station.
Appartenenze/credenze di fede e diritto penale: percorsi di laicità
Creators: name: Casuscelli, Giuseppe
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Testo integrale della relazione al Convegno su "" (Messina, 13-14 giugno 2008, Facoltà di Giurisprudenza), senza varianti e con il corredo dei richiami bibliografici e giurisprudenziali di base, destinatoalla pubblicazione negli Atti con le opportune aggiunte e modifiche.  SOMMARIO: 1. Laicità e diritto penale nella prospettiva dell’ecclesiasticista - 2.Laicità “neutrale” e laicità “religiosa”: un dilemma irrisolto – 3. Tutela penale delsentimento religioso e libertà di religione – 4. I risvolti promozionali della tutelapenale di “un” sentimento - 5. Tutela penale del sentimento religioso e dirittogiurisprudenziale - 6. L’esigenza di una riforma organica e profonda del dirittopenale “di religione”.Laicità e Multiculturalismo: Profilipenali ed extrapenali
description: Stato, Chiese e pluralismo confessionale, 2008: 24 novembre
Ossimori impliciti e tautologie esplicite nella disciplina della dispensa da disparitas cultus tra cattolici e islamici
Creators: name: La Camera, Francesco
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Il contributo, segnalato dalla Prof. Sara Domianello, è destinato allapubblicazione nel volume, a cura di V. Tozzi e G. Macrì, "", Edizioni Rubbettino, con il diverso titolo "Ossimori impliciti e tautologie esplicite. La disciplina della dispensadall’impedimento di  disparitas cultus  SOMMARIO: 1. Considerazioni preliminari - 2. La concessione della dispensa: ipoteri dell’Ordinario – 3. La natura dell’impedimento didisparitas cultus - 4. Lepromissiones prestate dai nubendi - 4.1 La dichiarazione di evitare il pericolo diabbandono della fede cattolica - 4.2 La promessa del battesimo e dell’educazionecattolica dei figli - 4.3 L’istruzione sui fini e sulle proprietà essenziali delmatrimonio - 4.4 L’informazione alla parte musulmana - 5. Conclusioni eprospettive future.nel matrimonio tra cattolici ed islamici, tra Codice di diritto canonico e Indicazioni della Presidenza CEI".Europa e Islam. Ridiscutere ifondamenti per la disciplina delle libertà religiose
description: Stato, Chiese e pluralismo confessionale, 2008: 24 novembre
Polymerase ζ is involved in mitochondrial DNA maintenance processes in concert with APE1 activity
Creators: name: Schreier, Heike
name: Wiehe, Rahel Stefanie
name: Ricchetti, Miria
name: Wiesmüller, Lisa
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: polymerase ζ
subject: mitochondrial DNA degradation
subject: oxidative damage
subject: base excision repair
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: DNA, Mitochondrial
subject: Mitochondria
subject: DNA damage
subject: Reactive Oxygen Species
subject: Mitochondriale DNS
subject: DNS-Schädigung
subject: Reaktive Sauerstoffspezies

description: Mitochondrial DNA (mtDNA) damaged by reactive oxygen species (ROS) triggers so far poorly understood processes of mtDNA maintenance that are coordinated by a complex interplay among DNA repair, DNA degradation, and DNA replication. This study was designed to identify the proteins involved in mtDNA maintenance by applying a special long-range PCR, reflecting mtDNA integrity in the minor arc. A siRNA screening of literature-based candidates was performed under conditions of enforced oxidative phosphorylation revealing the functional group of polymerases and therein polymerase ζ (POLZ) as top hits. Thus, POLZ knockdown caused mtDNA accumulation, which required the activity of the base excision repair (BER) nuclease APE1, and was followed by compensatory mtDNA replication determined by the single-cell mitochondrial in situ hybridization protocol (mTRIP). Quenching reactive oxygen species (ROS) in mitochondria unveiled an additional, ROS-independent involvement of POLZ in the formation of a typical deletion in the minor arc region. Together with data demonstrating the localization of POLZ in mitochondria, we suggest that POLZ plays a significant role in mtDNA turnover, particularly under conditions of oxidative stress.
Supplementary document for Quantitative laser speckle auto-inverse covariance imaging for robust estimation of blood flow - 5186031.pdf
Creators: name: Li, Pengcheng
name: hong, jiachi
name: Zhu, Xuan
name: Lu, Jinling
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: dependence of speckle contrast on sample size and cortical spreading depression
Kinderschutz und Schutzkonzepte im klinischen und ambulanten Bereich
Creators: name: Fegert, Jörg M.
name: Hoffmann, Ulrike
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Schutzkonzeptentwicklung
subject: Gewalt
subject: medizinische Institutionen
subject: child protection
subject: development of safeguarding measures
subject: medical-therapeutic institutions
subject: DDC 300 / Social sciences
subject: Child sexual abuse
subject: Violence
subject: Kinderschutz
subject: Sexualisierte Gewalt

description: Zusammenfassung. Die Auseinandersetzung mit Fällen von (sexualisierter) Gewalt gegen Kinder und Jugendliche sowie die Entwicklung von Schutzkonzepten war in den Institutionen des medizinisch-therapeutischen Bereiches über lange Zeit ein eher marginalisiertes Thema. Mit der Verankerung der Verpflichtung zur Erstellung von Schutzkonzepten gegen (sexualisierte) Gewalt in der Qualitätsmanagement-Richtlinie des Gemeinsamen Bundesausschusses (G-BA) müssen sich jedoch nun alle Kliniken und Praxen dieser Thematik stellen. Der vorliegende Themenschwerpunkt gibt einen Überblick über Daten und Zahlen (sexueller) Übergriffe gegen Kinder und Jugendliche in medizinischen Institutionen und beschäftigt sich mit den Ursachen von Übergriffen durch Angehörige der Heilberufe sowie den daraus folgenden notwendigen Interventionen. Weiteres Thema ist die Entwicklung von Schutzkonzepten gegen (sexuelle) Gewalt. Es werden Hinweise zum Aufbau sowie zur praktischen Umsetzung im klinischen und ambulanten Bereich gegeben.
A 70 anni dalla promulgazione della legislazione detta razziale
Creators: name: Fubini, Guido
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Relazione tenuta a Torino il 17 novembre 2008 presso la Fondazione Fulvio Croce
description: Stato, Chiese e pluralismo confessionale, 2008: 24 novembre
Towards Fluorinated Substrate Analogs and N-Acylated 2-Aminopyrimidine Inhibitors of Lipoxygenases
Creators: name: Haycock, Meghan Lynn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Lipoxygenase
Fluorinated Substrate Analogs

description: Cyclooxygenase (COX) and lipoxygenase (LOX) catalyze the rate-determining step in the production of arachidonic acid- derived signaling molecules (eicosanoids) within the body. COX has been extensively investigated, which has enabled the design of non-steroidal inflammatory drugs (NSAIDs) such as aspirin, acetaminophen (ApAP) and ibuprofen. However, there are still fundamental questions surrounding the LOX family of enzymes, which has limited the development of isoform specific inhibitors. The structural basis and regio- and stereoselectivity of the LOX isoforms are not known. Herein, we describe two strategies to develop isoform-specific inhibitors of lipoxygenase. Efforts were focused on the synthesis of unnatural lipid derivatives, in which the methylene hydrogen atoms on the substrate were replaced with a moiety lacking a labile hydrogen atom, such as fluorine. This would allow the LOX enzyme to remain in an active form, while preventing enzyme turnover. This preliminary work will enable the assessment of their activity as inhibitors and attempts at their co-crystallization might provide the first insight into the binding mode of these fatty acid substrates. The preparation of a small library of acylated 2-aminopyrimidines and their efficacy as inhibitors of soybean lipoxygenase-1 was explored. Preliminary studies suggest the mode of action occurs through a bi-dentate coordination of the ferric iron atom. Modifications of the acylated 2-aminopyrimidines to make it more substrate-like and to increase its lipophilicity, yielded inhibitors with low micromolar IC50 values. With further optimization, acyl 2-aminopyrimidines could serve as a useful platform for the discovery of safe and efficient isoform specific inhibitors.
Creative artefact: the taste of translation; and Exegesis: the inner outed
Creators: name: Gambling, Anne
Publisher: name: Swinburne
Year: 2024

description: How is new knowledge produced? For Deleuze & Guattari, 'the new is an outside that exists within this world, and as such it must be constructed' (O’Sullivan & Zepke 2008, p.2). My work demonstrates that practice-led research offers a liberating framework toward such 'production of the new' (O’Sullivan & Zepke 2008, p.2), an opportunity for the intuitive and creative wellspring of heart-knowing to cross-fertilise with the intellectual and reflective reservoir of the mind. Beginning with direct experience of the collective unconscious (Jung 1995), the research question I addressed in this project was: How do I bring inner knowing out onto an external plane? The particularities of my process toward the following research outcomes - an Exegesis titled The Inner Outed and a Creative Artefact, The Taste of Translation - documents how creative practice unlocks intellectual understanding as much as reflective inquiry underpins and enables ongoing creativity. In this way, research and practice coalesce to form a seamless whole. A rhizomatic methodology was used to explore an expanding fabric of interconnections, 'all manner of ‘becomings' (Deleuze & Guattari 2004, p.24), my writing the tool to chart territories explored as they were traversed. The rhizomes of both exegesis and artefact thus form a single 'plane of consistency' (Deleuze & Guattari 2004, p.9), of becoming knowledge, where thematic concepts such as engaging the other, memory, landscape and translation are interrogated together with what it means to love: 'Love is as love does […] We do not have to love. We choose to love' (Peck 1978, p.71). This submission is a small offering to the conversation on peace consciousness in a post-9/11 world which seems to have forgotten how to love according to the perennial philosophy (Huxley 2009) - that different religious traditions may appear to divide but compassion conjoins us all; that we are one humanity with many faces; and that we live in a world where, as Buddhist teachings suggest, love is “at the centre of all things and all things are the same thing' (Kerouac 2008, p.137).
Namensverwaltung und Adressierung in Distributed Shared Memory-Systemen
Creators: name: Lupper, Alfred
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Distributed shared memory systems
subject: Namensverwaltung
subject: DDC 004 / Data processing & computer science
subject: Memory hierarchy (Computer science)
subject: Adressierung

description: Die gegenwärtige Version des Naming-Systems stellt die grundlegenden Funktionen zur Verwaltung von Namen in DSM-Systemen zur Verfügung. Dabei wurde besonders Wert darauf gelegt, die positiven Eigenschaften des DHS zu nutzen. Das vorliegende Naming-System ist völlig ortstransparent und verwaltet somit keine expliziten Replikationen von Namenseinträgen, wie sie zur Steigerung der Zugriffsgeschwindigkeit notwendig sind. Replikation findet transparent auf Basis von Speicherseiten statt und wird von DHS verwaltet. Das Naming-System ist in keiner Weise mit der Konsistenz replizierter Namenseinträge befasst. Da jeder Zugriff auf eine Speicherseite Netzwerk-Transaktionen nach sich ziehen kann, ist darauf zu achten, die Anzahl der zugegriffenen Speicherseiten zu reduzieren. Dabei wird ausgenützt, dass lokal verwendete Namenseinträge mit der Zeit vom Memory Manager zusammen mit anderen lokal benötigten Einträgen in denselben Speicherseiten plaziert werden.
Local volume TiNy titans: Gaseous dwarf-dwarf interactions in the local universe
Creators: name: Pearson, Sarah
name: Besla, Gurtina
name: Putman, Mary E.
name: Lutz, Katharina A.
name: Fernandez, Ximena
name: Stierwalt, Sabrina
name: Patton, David R.
name: Kim, Jinhyub
name: Kallivayalil, Nitya
name: Johnson, Kelsey
name: Sung, Eon-Chang
Publisher: name: Swinburne
Year: 2024

description: In this paper, we introduce the Local Volume TiNy Titans sample (LV-TNT), which is a part of a larger body of work on interacting dwarf galaxies: TNT . This LV-TNT sample consists of 10 dwarf galaxy pairs in the Local Universe (<30 Mpc from MilkyWay), which span mass ratios ofM*,1/M*,2 < 20, projected separations <100 kpc, and pair member masses of log(M*/MŠ™) <9.9. All 10 LV-TNT pairs have resolved synthesis maps of their neutral hydrogen, are located in a range of environments and captured at various interaction stages. This enables us to do a comparative study of the diffuse gas in dwarf-dwarf interactions and disentangle the gas lost due to interactions with haloes of massive galaxies, from the gas lost due to mutual interaction between the dwarfs. We find that the neutral gas is extended in the interacting pairs when compared to non-paired analogues, indicating that gas is tidally pre-processed. Additionally, we find that the environment can shape the HI distributions in the form of trailing tails and that the gas is not unbound and lost to the surroundings unless the dwarf pair is residing near a massive galaxy. We conclude that a nearby, massive host galaxy is what ultimately prevents the gas from being re-accreted. Dwarf-dwarf interactions thus represent an important part of the baryon cycle of low-mass galaxies, enabling the 'parking' of gas at large distances to serve as a continual gas supply channel until accretion by a more massive host. This paper includes archived data obtained through the Australia Telescope Online Archive (http://atoa.atnf.csiro.au).
Le ninfe, i sileni e i centauri della Peonia: alcune considerazioni sulle monetazioni di età arcaica
Creators: name: Cavagna, Alessandro
Publisher: name: Aristonothos. Scritti per il Mediterraneo antico
Year: 2012

description: Forthcoming.
description: Aristonothos. Scritti per il Mediterraneo antico, No 6 (2012): Culti e miti greci in aree periferiche
Eracle a Taso. Iconografia monetale e aspetti del culto
Creators: name: Martinelli, Carmen
Publisher: name: Aristonothos. Scritti per il Mediterraneo antico
Year: 2012

description: Forthcoming.
description: Aristonothos. Scritti per il Mediterraneo antico, No 6 (2012): Culti e miti greci in aree periferiche
Η πορεία των REITs σε διεθνές και εθνικό επίπεδο από το 2015 μέχρι το 2023
Creators: name: Κατσάνου, Σπυριδούλα Ελένη Στέφανου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Α.Ε.Ε.Α.Π.
Brexit
Covid 19
REITs

description: Η παρούσα διπλωματική εργασία διενεργήθηκε στα πλαίσια του μεταπτυχιακού προγράμματος ‘Διοίκηση Επιχειρήσεων (ΜΒΑ)’ του τμήματος Οικονομικών Επιστημών του Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης, με θέμα ‘Η πορεία των REITs σε διεθνές και εθνικό επίπεδο από το 2015 μέχρι το 2023’.Σκοπός αυτής της διπλωματικής εργασίας είναι να εξετάσει την πορεία των Ανώνυμων Εταιριών Επενδύσεων σε Ακίνητη Περιουσία σε παγκόσμιο επίπεδο καθώς επίσης και των αντίστοιχων εταιριών στην Ελλάδα μετά από το 2015, και τους παράγοντες από τους οποίους έχουν επηρεαστεί. Στην εισαγωγή γίνεται μία γενική αναφορά στον ρόλο και τη σημαντικότητα που έχουν αποκτήσει οι επενδύσεις σε ακίνητη περιουσία στην παγκόσμια οικονομία και τις κρίσεις από τις οποίες πέρασαν κατά τη διάρκεια των ετών. Στο δεύτερο κεφάλαιο γίνεται ανάλυση των προϊόντων REITs, από ποιες κατηγορίες αποτελούνται, ποια είναι τα πλεονεκτήματα και τα μειονεκτήματά τους, την ιστορική αναδρομή τους και από ποιες οικονομικές κρίσεις επηρεάστηκαν σημαντικά μετά το 2015. Ακόμη αναλύεται η συσχέτιση που μπορεί να έχουν οι μετοχές των εταιριών που επενδύουν σε ακίνητα με τις υπόλοιπες μετοχές του χρηματιστηρίου. Στο τρίτο κεφάλαιο γίνεται έρευνα για την εξέλιξη των REITs στην Ελλάδα από το 2015 και μετά αναλύοντας την εξέλιξη των τιμών των μετοχών τεσσάρων σημαντικών εταιριών που επενδύουν σε ακίνητα και είναι εισηγμένες στο Χρηματιστήριο Αθηνών. Τέλος γίνεται αναφορά στην απόδοση του Γενικού Δείκτη τιμών του ΧΑ για να συγκριθεί με τις τιμές των Α.Ε.Ε.Α.Π.
description: This thesis was carried out as part of the postgraduate program 'Business Administration (MBA)' of the Department of Economic Sciences of the Aristotle University of Thessaloniki, on the topic 'The course of REITs in an international and national perspective from 2015 to 2023'. The purpose of this thesis is to examine the course of Real Estate Investment Companies at the global level as well as the corresponding companies in Greece after 2015, and the factors by which they have been affected. In the introduction, a general reference is made to the role and importance that real estate investments have acquired in the global economy and the crises they have gone through over the years. The second chapter analyzes the REITs products, what categories they consist of, what are their advantages and disadvantages, their historical background and by which financial crises they were significantly affected after 2015. The correlation that the companies' shares may have is also analyzed that invest in real estate with the rest of the stock market. In the third chapter, research is done on the evolution of REITs in Greece from 2015 onwards by analyzing the evolution of the share prices of four important companies that invest in real estate and are listed on the Athens Stock Exchange. Finally, reference is made to the performance of the General Price Index of the AX to be compared with the prices of REITs.
Supplementary document for Resonance-enhanced high harmonic in metal ions driven by elliptically polarized laser pulses - 5186133.pdf
Creators: name: Lai, Yu Hang
name: RAO, KONDA SRINIVASA
name: Liang, Jingguang
name: Wang, Xu
name: Guo, Chunlei
name: YU, WEILI
name: Li, Wei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplemental document
Understanding design thinking in practice: a qualitative study of design led professionals working with large organisations
Creators: name: Howard, Zaana
Publisher: name: Swinburne
Year: 2024

description: Design thinking is a collaborative and human centred approach to solving problems. This thesis aims to understand how design thinking is applied in practice with large organisations. Ethnographic research methods were adopted across three studies. Findings reveal design thinking in practice is an interdependent relationship between the approach, design led professional and environment in which it is conducted. Further, a design thinking maturity model is proposed, based upon two perspectives of design thinking as a way of work and a way of life. Evidence generated provides a framework for the public and design practitioners to better understand design thinking practice.
EOSC-hub Integration handbook for service providers
Creators: name: Sipos, Gergely
Publisher: name: Zenodo
Year: 2020
Subjects: EOSC Hub

description: The EOSC-hub project operates many of the core elements of the European Open Science Cloud, and acts as the main facilitator of onboarding new providers in EOSC. This handbook provides assistance for service providers who want to share services via EOSC with the use of EOSC-hub services. The document describes the various options for onboarding and service integrations, and points to specific manuals for further details. The handbook is meant to be used as a document to understand the ‘big picture’ of EOSC onboarding and to choose the best approach for integrating into it.
La conciliazione degli opposti. Il culto e il santuario di Artemide Tauropolos ad Anfipoli
Creators: name: Mari, Manuela
Publisher: name: Aristonothos. Scritti per il Mediterraneo antico
Year: 2012

description: Forthcoming.
description: Aristonothos. Scritti per il Mediterraneo antico, No 6 (2012): Culti e miti greci in aree periferiche
High Prognostic Value of mini-laparoscopy for advanced liver disease-related complications in patients with HCV infection
Creators: name: Zizer, Eugen
name: Backhus, Johanna
name: Bohl, Stephan
name: Braun, Anette
name: Baturina, Irina
name: Klass, Dietmar
name: Dikopoulos, Nektarios
name: Seufferlein, Thomas
name: Dollinger, Matthias
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Advanced chronic liver disease
subject: Cirrhosis
subject: HCV
subject: Mini-laparoscopy
subject: DDC 610 / Medicine & health
subject: Liver diseases
subject: Fibrosis
subject: Laparoscopy
subject: Leberkrankheit
subject: Leberzirrhose
subject: Laparoskopie
subject: Hepatitis C

description: Background/Aim: The assessment of advanced chronic liver disease (ACLD) is a prerequisite for therapy and surveillance in patients with chronic hepatitis C infection. Mini-laparoscopy-assisted liver biopsies facilitate both histological and macroscopical evaluation of liver fibrosis. This study is aimed at investigating the prognostic significance of the laparoscopic assessment for the cumulative incidence of ACLD-related events. Patients and Methods: We performed a single center, retrospective analysis of 94 patients with either macroscopically or/and microscopically assessed advanced fibrosis/cirrhosis caused by chronic hepatitis C infection. The patients' data, the respective laboratory results, and follow-up period were evaluated in the outpatient clinic. Results: The group with both macro- and microscopic diagnosed ACLD showed a significantly higher number of decompensating events (n = 7) compared with the other 2 groups (n = 0 in the group with only histological and n = 1 in the group with only laparoscopic diagnosis of advanced liver disease). The results were not affected by the successful treatment of the hepatitis C virus. In the Cox-regression analysis, the spleen size (>120 mm) was significantly associated with the incidence of ACLD-related events. Conclusions: Assessment of ACLD in chronic hepatitis C by mini-laparoscopy-assisted liver biopsies may facilitate the selection of patients with a poor prognosis, irrespective of achieving a sustained virological response following treatment. Follow-up of these patients should be intensified to treat decompensation early. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Questionnaire for the detection of autoimmune associated symptoms and factors
Creators: name: Mack, Axel
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: FAISF
subject: Autoimmunity
subject: Mild encephalitis
subject: Autoimmune diseases
subject: Encephalitis

description: In the study “Familiäre Häufing von Depressionen und Psychosen: eine biographisch medizinische Detailanalyse von autoimmunen und infektiösen Faktoren in einer Familie“ (Familial accumulation of Depression and Psychosis: a biographical medical analysis in Detail of autoimmune and infectious factors in a family) by A. Mack (2017), we designed, tested and applied a new kind of questionnaire to detect early and subclinical signs of autoimmunity in patients with psychiatric diseases and a possible underlying autoimmune disease. Further we constructed and added questions to detect environmental factors, such as infections, toxins and genetic accumulation of psychiatric and autoimmune diseases and embedded these in a self-editable catalogue of questions, similarly structured to a physicians anamnesis. This Questionnaire called “Fragebogen zur Erkennung von autoimmunassoziierten Symptomen und Faktoren“ (Questionnaire for the detection of autoimmune associated symptoms and factors) is now translated in English and published as a supplement.
Hybrid multi-tube concrete columns incorporating advanced composite materials
Creators: name: Sirach, Nicholas
Publisher: name: Southern Cross University
Year: 2022
Subjects: Fibre-reinforced polymer
FRP
Multi-tube concrete column
MTCC
Confinement
Hybrid column
Concrete
Steel

description: A new form of hybrid structural column that can enhance the compressive strength and ultimate strain of concrete is the fibre-reinforced polymer (FRP)-confined multi-tube concrete column (MTCC). MTCCs comprise of an outer FRP tube, multiple internal metallic tubes, and a concrete infill. This column form offers many benefits over existing column forms, such as strength and ductility enhancements, improved corrosion resistance, constructability, and cost-effectiveness. This PhD thesis aims to expand the understanding of the confinement mechanism of MTCCs by investigating the influence that key column parameters have on their axial compressive behaviour. Both experimental and theoretical investigations were undertaken to achieve this objective.
description: The experimental component of this thesis consists of three test programmes. The first experimental programme consisted of monotonic axial compression tests on FRP-confined concrete to gain an improved understanding of the confinement mechanism of normal- and high-strength concrete confined with different FRP jackets. The second experimental programme consisted of monotonic axial compression tests on MTCCs to investigate the influence of several key parameters on their compressive response. The test results show that MTCCs effectively confine the concrete by delaying buckling of the internal tubes, resulting in significant strength and ductility enhancements. The third experimental programme consisted of cyclic axial compression tests on MTCCs. The experimental results show that MTCCs have a large deformation capacity under cyclic axial compression, and the envelope curve resembles the corresponding MTCC subjected to monotonic compression.
description: The theoretical component of this thesis involves the development of models of varying levels of complexity. Firstly, a unified dilation equation was developed for normal- and high-strength concrete confined with FRP composites with rupture strains of up to 9%. This equation can be used in conjunction with existing analysis-oriented stress-strain models for confined concrete. A three-dimensional finite element (FE) model was then developed to understand the complex confinement mechanism of MTCCs with different column parameters and was verified against the experimental results. Using this FE model, a parametric study was undertaken to produce a comprehensive database of stress-strain responses of concrete in MTCCs. This database was then used to develop an analytical stress-strain model for concrete in MTCCs. An existing cyclic stress-strain model developed for FRP-confined concrete columns was used to predict the unloading/reloading curves of concrete in the experimentally tested MTCCs. The existing cyclic model was modified to include the analytical model developed for MTCCs to predict the full cyclic response of the concrete in MTCCs.