cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
El papel de la mujer y la figura de autoridad dentro del sistema organizativo arhuaco
Creators: name: Chaparro Mejía, Gunawin
Publisher: name: Universidad Externado de Colombia
Year: 2024
Subjects: subject: Mujeres en el desarrollo social
subject: Liderazgo - Relaciones con mujeres
subject: Comunidad indígena - Aspectos sociales
subject: Ley de origen
subject: Organización arhuaca
subject: Rol de mujeres
subject: Kunsamu

description: Nuestro objetivo con este trabajo ha sido comprender cómo las mujeres participan en la gobernabilidad y cómo perciben su propio rol en el liderazgo y la influencia dentro de esta estructura comunitaria. Es necesario ahondar en estos temas para captar la complejidad del proceso de liderazgo de la mujer en el contexto arhuaco, esto nos permite entender sus puntos de vista y experiencias en nuestras formas de organización, ya entendiendo esto, ampliamos nuestra comprensión de la dinámica de liderazgo, porque reconocemos la importancia de una visión integral que es partiendo desde la Ley de Origen Desde este pensamiento todo se rige por la ley de origen que es un orden preestablecido y sostenido por la fuerza femenina y con ella haciendo posible la existencia del kunsamu como el conocimiento arhuaco dentro de la comunidad, por ello partimos teniendo como base la definición de los mamus, las autoridades, y mujeres lideresas pues ellos dentro de la comunidad desempeñan un papel fundamental.
description: Our objetive with this research project has been to understand how women participate in the governance how they perceive their own role in leadership, and their influence within the community structure. It is necessary to examine these issues in order to understand the complexity of the leadership process of women in the context of the Arhuaco people. This also allows us to understand their opinions and experiences in our organizational structure. With a knowledge of this, we will have a better understanding of the dynamics of leadership because we recognize the importance of an integral vision coming from our Original Law. From this point of view, everything comes from the Original Law, which is a law preestablished and sustained by feminine force, or way of being, and which makes possible the 'kunsamu', (the Arhuaco way of thinking), within the community. Mamus (spiritual leaders) authorities and women leaders are guided by this Law, and they play a fundamental role within the community.
Fuimos eso que no se cuenta, pero vamos a hablarlo. Las semillas y alimentos como base de la vida en Sogromin, Niwi Umuke (Sierra Nevada de Santa Marta) Un relato e investigación familiar en tres generaciones
Creators: name: Torres Chaparro, Gunkeywia
Publisher: name: Universidad Externado de Colombia
Year: 2024
Subjects: subject: Comunidades indígenas - Aspectos sociales
subject: Pueblos - Indígenas
subject: Lugares sagrados - Religión y mitología
subject: Ciclos de vida ikʉ y las semillas
subject: Materialidad y espiritualidad
subject: Colectividad
subject: Kia
subject: Tani

description: Este trabajo recorre las voces y vivencias de los mamʉ y los abuelos, explorando la relación intrínseca entre el hombre y las semillas. Desde la llegada de los curas Capuchinos y otros eventos que marcaron la transformación de vida de las comunidades ikʉ, esta investigación plasma las experiencias de tres generaciones aún presentes, testigos de los modos de vida de otros tiempos. Asimismo, nos permite comprender cómo al perder esta noción de vida, también se está perdiendo la base de la existencia, que funciona de manera colectiva, con un respeto y cuidado mutuo entre las semillas y los alimentos, como un solo ser.
description: This paper journeys through the voices and Life experiences of the Mamʉs and the elders, exploring the intrinsic relationship between people and seeds. Since the arrival of the Capuchin priests, and other events relating to the transformation of life in the Ikʉ communities, this research paper examines the experiences of three generations, still active, and witnesses to the old ways of living. At the same time, it let's us understand that if we lose this way if living, we will also lose the basis of existente. This works in a collective manner, showing respect and mutual care for seeds and other fooddtuffs, as if they were.
Conflictos socioambientales: una mirada a la palma africana o de aceite y su desarrollo histórico en San Alberto, Cesar
Creators: name: Moncada Moncada, Juan Felipe
Publisher: name: Universidad Externado de Colombia
Year: 2024
Subjects: subject: Agricultura - Aspectos socioeconómicos
subject: Cultivos - Aspectos sociales
subject: Política pública - Aspectos ambientales
subject: Conflictos socioambientales
subject: Desarrollo local
subject: Palma africana
subject: Agroindustria
subject: Cesar

description: La palma africana o de aceite ocupa en Colombia uno de los sectores agroindustriales más grandes de nuestro territorio. A nivel nacional en cuanto a producción y beneficios técnicos ha transformado extensos campos que mantenían otros usos agrícolas principalmente, lo que ha generado conflictos socioambientales por sus impactos y consecuencias locales por el acceso a elementos naturales y la protección del empleo y la economía local. El objetivo de la presente investigación es analizar los conflictos socioambientales de cultivos de palma africana en San Alberto, César, población destacada por el trabajo en esta agroindustria. Este estudio, fue realizado teniendo en cuenta como enfoques, una parte histórica y se utilizó una metodología de tipo cualitativa que recogió en campo entrevistas de tipo semiestructurada y de historia de vida, contando con la participación de trabajadores dedicados a la palmicultura y labores técnicas, así como una mesa de diálogo que trajo las voces de la comunidad para presentar propuestas a las futuras potencialidades locales del municipio.
description: The African or oil palm in Colombia occupies one of the largest agroindustrial sectors in our territory. At the national level in terms of production and technical benefits, it has transformed extensive fields that mainly maintained other agricultural uses, which has generated socio-environmental conflicts due to its local impacts and consequences due to access to natural elements and the protection of employment and the local economy. The objective of this research is to analyze the socio-environmental conflicts of African palm crops in San Alberto, César, a town notable for its work in this agroindustry. This study was carried out taking into account a historical part as approaches and a qualitative methodology was used that collected semi-structured and life history interviews in the field, with the participation of workers dedicated to palm cultivation and technical work. as well as a dialogue table that brought the voices of the community to present proposals for the future local potential of the municipality.
Gephi network visualisation
Creators: name: I Watitula Longkumer
Publisher: name: figshare
Year: 2016
Subjects: Digital Humanities

description: This network visualisation shows the result carried out on 3 works of fiction, Easterine Kire When the River Sleeps (2015), Mamang Dai's The Black Hill (2015) and Legends of Pensam (2006) and 9 scholarly articles.
Bilingual language switching costs in auditory comprehension
Creators: name: Olson, Daniel J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Previous research on bilingual language switching and lexical access has demonstrated a consistent reaction time cost associated with producing a switched token. While some studies have shown these costs to be asymmetrical, with bilinguals evidencing a greater delay when producing switches into their dominant language relative to the non-dominant language, others have shown symmetrical costs, depending on individual (e.g. proficiency) and contextual (e.g. language mode) factors. The current study, employing an eye-tracking paradigm, extends this line of research by examining the potential for switch costs during auditory comprehension. Paralleling previous production-oriented research, results of the current study demonstrate flexible switch costs during auditory comprehension. Switch costs were asymmetrical in monolingual mode, with greater costs incurred when switching into the dominant language, and uniformly absent in bilingual mode. Results are discussed with respect to bilingual language selection mechanisms in both production and comprehension.
El negro no es sólo un color: discriminación racial y afectaciones psicosociales en la comunidad estudiantil negra, afro, raizal y palenquera de la Universidad Externado de Colombia
Creators: name: Pereira Vasquez, Camila Andrea
Publisher: name: Universidad Externado de Colombia
Year: 2024
Subjects: subject: Desigualdad cultural - Aspectos sociales
subject: Problemas raciales - Aspectos morales y éticos
subject: Trabajo social con jovenes - Ciudad universitaria
subject: Discriminación racial
subject: Estigma
subject: Estereotipos
subject: Afectaciones psicosociales

description: La tesis de investigación, analiza la discriminación racial en el entorno universitario y su impacto psicosocial en la comunidad Negra, Afrodescendiente, Palenquera y Raizal (NARP). Se estructura en torno a tres ejes conceptuales: la comunidad, la discriminación racial y las afectaciones psicosociales. A través de un enfoque cualitativo, se busca problematizar estas cuestiones y dar voz a las experiencias y percepciones de la comunidad estudiantil. Mediante el análisis de historias de vida, entrevistas y encuesta de caracterización, se exploran las vivencias de discriminación racial y cómo estas afectan el bienestar emocional y psicológico de los estudiantes. El estudio también destaca la importancia de la sensibilización, la educación y la implementación de políticas equitativas para abordar el racismo sistémico en el ámbito universitario de la Universidad Externado.
description: This research article analyzes racial discrimination in the university environment and its psychosocial impact on the Black, Afro-descendant, Palenquera and Raizal (NARP) community. It is structured around three conceptual axes: the community, racial discrimination, and psychosocial effects. Through a qualitative approach, we seek to problematize these issues and give voice to the experiences and perceptions of the student community. Through the analysis of life stories, interviews and a characterization survey, experiences of racial discrimination are explored and how they affect the emotional and psychological well-being of students. The study also highlights the importance of awareness, education, and the implementation of equitable policies to address systemic racism in the university Externado.
Inflectional complexity and experience affect plural processing in younger and older readers of Dutch and German
Creators: name: Reifegerste, Jana
name: Meyer, Antje S.
name: Pienie Zwitserlood
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: According to dual-route models of morphological processing, regular inflections can be retrieved as whole-word forms or decomposed into morphemes. Baayen, Dijkstra, and Schreuder [(1997). Singulars and plurals in Dutch: Evidence for a parallel dual-route model. Journal of Memory and Language, 37, 94–117. doi:10.1006/jmla.1997.2509] proposed a dual-route model in which singular-dominant plurals (“brides”) are decomposed, while plural-dominant plurals (“peas”) are accessed as whole-word units. We report two lexical-decision experiments investigating how plural processing is influenced by participants’ age and morphological complexity of the language (German/Dutch). For all Dutch participants and older German participants, we replicated the interaction between number and dominance reported by Baayen and colleagues. Younger German participants showed a main effect of number, indicating decomposition of all plurals. Access to stored forms seems to depend on morphological richness and experience with word forms. The data pattern fits neither full-decomposition nor full-storage models, but is compatible with dual-route models.
Substrate-induced adjustment of “slipped” π–π stacking: en route to obtain 1D sandwich chain and higher order self-assembly supramolecular structures in solid state
Creators: name: Shen, Meng-Jie
name: Tong-Ling Liang
name: Song, Yue-Qiang
name: Xu, Li-Jin
name: Hao, Xiang
name: Han-Yuan Gong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: ‘Slipped’ π−π stacking between flexible macrocycle 14+ (cyclo[2](2,6-di(1H-imidazol-1-yl)pyridine)[2](1,4-dimethylene benzene)) and neutral small molecules induce one-dimensional (1D) ‘sandwich’ chain self-assembly. Unlike most of the reported π−π stacking system, the 1D “sandwich” chain expands with the direction parallel to stacking π surfaces on 14+ and that on molecule 2, 3, 4 or 5 (2 = p-xylene, 3 = benzene-1,4-diamine, 4 = 4,4′-bipyridine, 5 = [1,1′-biphenyl]-4,4′-diol). Moreover, the π−π stacking modes of 1D self-assembly are seriously small molecule adduct dependent. Combined with the other weak interactions (e.g. intermolecular hydrogen bonding), the new substrate design and control strategy can expand the 1D ‘sandwich’ chain (e.g. [14+·4]n) into higher order structure (e.g. two-dimensional (2D) network [14+·4·6]n, 6 = hydroquinone) even in large scale (~280 mg). This 2D network structure, which keeps stable under 423 K, shows highly selective gas absorption of CO2 over N2.
Trabajo, familia y nuevas formas de explotación susurros de los niños, niñas y adolescentes de las montañas Chirlobirlo del sur de Bogotá - Caracoli
Creators: name: Fernández Espinel, Daniela
Publisher: name: Universidad Externado de Colombia
Year: 2024
Subjects: subject: Familia - Aspectos morales y éticos
subject: Planificación económica - Historia
subject: Trabajo - Aspectos sociales
subject: Territorio – memoria - comunidad
subject: Trabajo
subject: NNAs y familias
subject: Hiperconsumo
subject: Nuevas formas de explotación

description: En esta investigación denominada, Trabajo, familia y nuevas formas de explotación Susurros de los Niños Niñas y Adolescentes de las montañas chirlobirlo del sur de Bogotá - Caracolí. Se centra en el análisis crítico de las complejas implicaciones sociales, económicas y culturales que surgen debido a las nuevas formas de “explotación” no convencional de los NNAs en el barrio Caracolí de Ciudad Bolívar. Esta investigación aborda cuatro ejes temáticos conceptuales que se describen a lo largo de los capítulos de la tesis, estos están construidos de la siguiente manera territorio habitado, los NNAs y sus familias, trabajo - consumo y nuevas formas de explotación , de esta manera, el propósito de esta investigación se justifica en resaltar el papel fundamental que desempeñan las narrativas compartidas en la construcción de la voz de aquellas vivencias y sentidos que se entretejen entre los NNAs, familias y políticas públicas.
description: In this research called, Work, family and new forms of exploitation Whispers of the Boys, Girls and Adolescents of the Chirlobirlo mountains of the south of Bogotá - Caracolí. It focuses on the critical analysis of the complex social, economic and cultural implications that arise due to new forms of unconventional “exploitation” of children and adolescents in the Caracolí neighborhood of Ciudad Bolívar. This research addresses four conceptual thematic axes that are described throughout the chapters of the thesis, these are constructed as follows: inhabited territory, children and adolescents and their families, work - consumption and new forms of exploitation, in this way, the The purpose of this research is justified in highlighting the fundamental role that shared narratives play in the construction of the voice of those experiences and meanings that are interwoven between children, families and public policies.
Maternidad y paternidad en conflicto en el municipio de aguazul
Creators: name: Granados Romero, Laura Katerin
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Hogar - Aspectos socioeconómicos
subject: Maternidad - Aspectos sociales
subject: Trabajo social - Investigaciones
subject: Maternidad
subject: Paternidad
subject: Aguazul
subject: Roles de género
subject: Conflicto familiar

description: "Maternidad y paternidad en conflicto en el municipio de Aguazul" es una tesis que se sumerge en las percepciones de la población local sobre estos roles fundamentales. A través de un análisis profundo, se explorarán las tensiones diarias que surgen en los hogares, centrándose en la distribución de tareas y en los roles asignados a hombres y mujeres. Este estudio pretende arrojar luz sobre cómo estas dinámicas influyen en la crianza de los hijos, así como en la estructura misma de la familia. El objetivo de esta investigación va más allá de lo local, aspira a enriquecer no solo la comprensión dentro de Aguazul sobre la maternidad y la paternidad, sino también a contribuir a los discursos más amplios sobre género y familia en un contexto global en constante cambio. A través de este análisis, se busca abrir puertas al diálogo y la reflexión que puedan impulsar cambios positivos tanto a nivel local como en el panorama más amplio de la sociedad contemporánea.
description: "Motherhood and paternity in conflict in the municipality of Aguazul" is a thesis that delves into the perceptions of the local population about these fundamental roles. Through an in-depth analysis, the daily tensions that arise in homes will be explored, focusing on the distribution of tasks and the roles assigned to men and women. This study aims to shed light on how these dynamics influence parenting, as well as the structure of the family itself. The objective of this research goes beyond the local, it aspires to enrich not only the understanding within Aguazul about motherhood and fatherhood, but also to contribute to broader discourses on gender and family in an everchanging global context. Through this analysis, we seek to open doors to dialogue and reflection that can promote positive changes both at the local level and in the broader panorama of contemporary society.
title: OFROM: interview avec unine11b10m
Creators: name: Delafontaine, François
name: Chételat, Lucile
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.9c0d7wz7.v2#8c7421d9a0e212b2e08892cb3d5e708f9c6bb8cb
Cautious adaptation of defiant components
Creators: name: Maia, Paulo Henrique
name: Vieira, Lucas
name: Chagas, Matheus
name: Yu, Yijun
name: Zisman, Andrea
name: Nuseibeh, Bashar
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 4612
subject: Software engineering

description: Systems-of-systems are formed by the composition of independently created software components. These components are designed to satisfy their individual requirements, rather than the global requirements of the systems-of-systems. We refer to components that cannot be adapted to meet both individual and global requirements as “defiant” components. In this paper, we propose a “cautious” adaptation approach which supports changing the behaviour of such defiant components under exceptional conditions to satisfy global requirements, while continuing to guarantee the satisfaction of the components’ individual requirements. The approach represents both normal and exceptional conditions as scenarios; models the behaviour of exceptional conditions as wrappers implemented using an aspect-oriented technique; and deals with both single and multiple instances of defiant components with different precedence order at runtime. We evaluated an implementation of the approach using drones and boats for an organ delivery application conceived by our industrial partners, in which we assess how the proposed approach helps achieve the system-of-systems’ global requirements while accommodating increased complexity of hybrid aspects such as multiplicity, precedence ordering, openness, and heterogeneity.
Desaparición forzada en Colombia : descripción del ecosistema de datos frente a una necesidad de búsqueda
Creators: name: Moncada Guevara, Daniela
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Personas desaparecidas - Condiciones sociales
subject: Política pública - Aspectos socioeconómicos
subject: Victimas de la guerra - Aspectos sociales
subject: Ecosistema de datos
subject: Desaparición forzada
subject: Trabajo Social
subject: Búsqueda
subject: Política Pública

description: La desaparición forzada en Colombia ha dejado una herida permanente en la sociedad Colombiana. Este trabajo de investigación aborda el complejo ecosistema de datos sobre desaparición forzada en el país, con el objetivo de comprender su alcance, características y potencialidades. A través de un análisis de fuentes de información cuantitativas como informes oficiales, bases de datos gubernamentales y civiles y experiencias de los grupos buscadores, se analiza la calidad, integridad y accesibilidad de los datos que configuran este ecosistema. Se identifican desafíos clave en la recopilación y gestión de datos, la falta de coordinación entre entidades de búsqueda y la estigmatización de las víctimas. Además, se exploran iniciativas y prácticas que podrían mejorar la recopilación y el análisis de datos para abordar esta problemática que hoy más que nunca se encuentra en la lupa política de frente a una posibilidad de política pública. Este trabajo dibuja un panorama integral sobre la producción y manejo de datos de desaparición forzada en el país y ofrece recomendaciones para fortalecer la respuesta institucional y promover la verdad, la justicia y la reparación para las víctimas. Además de abordar el peso y la responsabilidad histórica que trae consigo hablar de desaparición forzada en Colombia.
description: Enforced disappearance in Colombia has left a permanent wound in Colombian society. This research paper addresses the complex ecosystem of data on enforced disappearance in the country, with the objective of understanding its scope, characteristics and potential. Through an analysis of quantitative information sources such as official reports, government and civilian databases and experiences of search groups, the quality, integrity and accessibility of the data that make up this ecosystem are analyzed. It identifies key challenges in data collection and management, the lack of coordination between search entities and the stigmatization of victims. In addition, it explores initiatives and practices that could improve data collection and analysis to address this issue, which today more than ever is in the political spotlight as a public policy possibility. This work paints a comprehensive picture of the production and management of data on enforced disappearance in the country and offers recommendations to strengthen the institutional response and promote truth, justice and reparations for victims. It also addresses the historical weight and responsibility that comes with talking about enforced disappearance in Colombia.
title: OFROM: interview avec unine11b09m
Creators: name: Delafontaine, François
name: Cerdeira, Vanessa
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.345c5m71.v2#96ce8325093d089e418b1d1ba370b3ad72ed7c8b
Comparisons of the Arabidopsis thaliana High-affinity Nitrate Transporter Complex AtNRT2.1/AtNAR2.1 and the Aspergillus nidulans AnNRTA: structure function considerations
Creators: name: Kotur, Zorica
name: Unkles, Shiela E.
name: Glass, Anthony D. M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: The high-affinity nitrate transporter of green plants is composed of two polypeptides, NRT2.1 and NAR2.1, while in fungi it appears that nitrate influx is mediated by NRT2 alone. Another difference between plants and fungi is that the central (cytoplasmic) loop of the 12 membrane spanning regions of NRT is quite large in fungi, consisting of 91 amino acid residues, compared with the relatively short (21 amino acid residues) plant NRT2.1. Here we examine potential amino acid residues involved in the plant NRT2.1:NAR2.1 association by mutation of conserved amino acids in Arabidopsis thaliana AtNRT2.1. Only the replacement of leucine 85 by glutamine disrupted the association between AtNRT2.1 and AtNAR2.1, as examined using the yeast two-hybrid system. Further, to investigate the nitrate-transporting function of AtNRT2.1 in a context free of other members of the NRT2 family, we expressed AtNRT2.1 in Aspergillus nidulans. In the fungal context the plant NRT alone was capable of restoring nitrate transport to a nitrate transport defective mutant, but only when the AtNRT2.1 central loop was replaced by its fungal counterpart.
The Rapid Mood Screener (RMS): a novel and pragmatic screener for bipolar I disorder
Creators: name: McIntyre, Roger S.
name: Patel, Mehul D.
name: Masand, Prakash S.
name: Harrington, Amanda
name: Gillard, Patrick
name: McElroy, Susan L.
name: Sullivan, Kate
name: Montano, C. Brendan
name: Brown, T. Michelle
name: Nelson, Lauren
name: Jain, Rakesh
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Depressive episodes and symptoms of bipolar I disorder are commonly misdiagnosed as major depressive disorder (MDD) in primary care. The novel and pragmatic Rapid Mood Screener (RMS) was developed to screen for manic symptoms and bipolar I disorder features (e.g. age of depression onset) to address this unmet clinical need. A targeted literature search was conducted to select concepts thought to differentiate bipolar I from MDD and screener tool items were drafted. Items were tested and refined in cognitive debriefing interviews with individuals with self-reported bipolar I or MDD (n = 12). An observational study was conducted to evaluate predictive validity. Participants with clinical interview-confirmed bipolar I or MDD diagnoses (n = 139) completed a draft 10-item screening tool and other questionnaires. Data were analyzed to identify the smallest possible subset of items with optimized sensitivity and specificity. Adults with confirmed bipolar I (n = 67) or MDD (n = 72) participated in the observational study. Ten draft screening tool items were reduced to 6 final RMS items based on the item-level analysis. When 4 or more items of the RMS were endorsed (“yes”), sensitivity was 0.88 and specificity was 0.80; positive and negative predictive values were 0.80 and 0.88, respectively. These properties were an improvement over the Mood Disorder Questionnaire in the same analysis sample while using 60% fewer items. The pragmatic 6-item RMS differentiates bipolar I disorder from MDD in patients with depressive symptoms, providing real-world guidance to primary care practitioners on whether a more comprehensive assessment for bipolar I disorder is warranted.
Safety of tapentadol compared with other opioids in chronic pain treatment: network meta-analysis of randomized controlled and withdrawal trials
Creators: name: Freynhagen, R.
name: Elling, C.
name: Radic, T.
name: Sohns, M.
name: Liedgens, H.
name: James, D.
name: McCool, R.
name: Edwards, M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: To assess the relative safety of oral tapentadol PR and other opioid analgesics for moderate or severe chronic pain in adults, we conducted a systematic review and network meta-analysis (NMA). A systematic review was conducted to identify randomized controlled trials (RCTs) and randomized withdrawal trials of tapentadol with other WHO stage II and III opioid analgesics in patients with moderate or severe chronic pain. Searches were conducted in MEDLINE, EMBASE, PubMed, Cochrane databases and trial registries. Feasibility assessment evaluated the trials’ suitability for NMA. Outcomes assessed were overall AEs, overall serious adverse events, constipation, nausea, dizziness, somnolence, headache, and discontinuation due to AEs. Randomized withdrawal trials were analyzed separately to other RCTs. Searches conducted in April 2019 identified 16,604 records. Following screening and feasibility assessment, 29 RCTs and 19 randomized withdrawal trials were identified and included in the NMA. Consistent with existing research, evidence from RCTs suggested that tapentadol is associated with relatively lower odds of adverse events occurring than most active comparators. The withdrawal trial data were less clear, with higher uncertainty around the results, and results that appear to contradict the RCT evidence. There are a number of trial design factors that may be affecting these results. RCT evidence suggests that tapentadol can be a useful treatment option for patients suffering from chronic pain and in need of an opioid analgesic. Opioids should be prescribed by a qualified physician only after other analgesics have been considered, taking side effects and misuse risk into account.
The burden of disease in early schizophrenia – a systematic literature review
Creators: name: Crespo-Facorro, Benedicto
name: Such, Pedro
name: Nylander, Anna-Greta
name: Madera, Jessica
name: Resemann, Henrike K.
name: Worthington, Emma
name: O’Connor, Molly
name: Drane, Emma
name: Steeves, Sara
name: Newton, Richard
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Schizophrenia is a heterogeneous disorder with a burden that can vary greatly depending on the severity and the duration. Previous research has suggested that patients in the earlier stages of schizophrenia (typically first-episode schizophrenia) benefit from effective early treatment, however, a comprehensive review of the burden specifically in this population has not been undertaken. A systematic literature review was therefore conducted to characterize the clinical, economic, and humanistic burden, as reported in naturalistic studies of schizophrenia populations specifically at an early stage of disease in comparison with healthy controls, patients with chronic schizophrenia, and patients with other psychiatric disorders. Searches were conducted in MEDLINE, MEDLINE In-Process, Embase, PsycINFO, and EconLit databases for records published between January 2005 and April 2019, and of relevant conference abstracts published between January 2014 and May 2019. Data were extracted from relevant publications and subjected to qualitative evaluation. Fifty-two publications were identified for inclusion and revealed a considerable burden for early schizophrenia with regards to mortality, psychiatric comorbidities such as substance abuse and depression, poor social functioning, and unemployment. Comparisons with chronic schizophrenia suggested a greater burden with longer disease duration, while comparisons with other psychiatric disorders were inconclusive. This review uncovered various gaps in the available literature, including limited or no data on incarcerations, caregiver burden, and costs associated with early schizophrenia. Overall, the burden of schizophrenia is apparent even in the early stages of the disease, although further research is required to quantify the burden with chronic schizophrenia and other psychiatric disorders.
Cost–utility analysis of second-line therapy with rituximab compared to tumour necrosis factor inhibitors in rheumatoid arthritis
Creators: name: Lopatina, Elena
name: Marshall, Deborah A.
name: Coupal, Louis
name: Le Lorier, Jacques
name: Choquette, Denis
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: To compare direct costs and treatment utility associated with the second-line therapy with rituximab and tumour necrosis factor inhibitors (TNFis) (adalimumab, etanercept, and infliximab) in patients with Rheumatoid Arthritis (RA) using data from a prospective registry. Health Assessment Questionnaire Disability Index (HAQ-DI) scores and RA-related healthcare resource utilization data (biologic agents and visits to rheumatologists) were extracted from a registry (Quebec, Canada) for patients with RA (n = 129) who had to discontinue a first-line TNFi and were treated with rituximab, adalimumab, etanercept, or infliximab as the second-line therapy between January 2007 and May 2016. A decision analytic model followed patients for 1 and 6 years. Treatment utility was measured as quality-adjusted life-years (QALYs) gained, which were calculated from HAQ-DI scores observed over the follow-up time. Quebec 2020 unit costs (Canadian Dollars, $) were used to value healthcare resource consumption. A probabilistic sensitivity analysis was performed with 10,000 Monte Carlo simulations to assess uncertainty around point-estimates of cost-utility. Over 1-year, rituximab and etanercept resulted in the effectiveness of 0.80 QALYs gained at the cost of $14,291and $18,880, respectively, and were dominant (i.e. associated with lower costs and more QALYs gained) compared to adalimumab (0.79 QALYs, $18,825) and infliximab (0.76 QALYs, $20,158). Over 6-years, rituximab (4.42 QALYs, $82,402) was dominant compared to adalimumab (4.30 QALYs, $101,420), etanercept (4.02 QALYs, $99,191), and infliximab (3.71 QALYs, $100,396). In the probabilistic analysis, rituximab was dominant over adalimumab, etanercept, and infliximab with the probability of 0.51, 0.62, and 0.65, respectively. Real-world data revealed differences between alternative biologic agents used as the second-line therapy in terms of both treatment costs for the healthcare system and utility of treatment for patients. Therefore, new guidelines on the order of selecting and switching biologic agents should be explored.
On a Tumulus at Old Parks, Kirkoswald: with some Remarks on One at Aspatria, and also on Cup, Ring, and other Rock Markings in Cumberland and Westmorland.
Creators: name: Ferguson, Richard S
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 13, 389-399
title: OFROM: interview avec unine11b07m
Creators: name: Delafontaine, François
name: Carbotti, Jennifer
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.a5fds43r.v2#c17472445dac19afd95d559a0740af5726bfb935
title: OFROM: interview avec unine11b05m
Creators: name: Delafontaine, François
name: Bolgiani, Marina
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.88bb4t50.v2#4e8f1911cd3b1af0b488917b1729a8c47fd37421
title: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 54
Creators: name: Aubert, Eduardo Henrik
name: Brochard, Pierre
name: Aubert, Eduardo Henrik
name: Brochard, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Laboratoire de médiévistique occidentale de Paris
subject: Semur-en-Auxois
subject: LaMOP

description: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 54

production-software: eScriptorium + Kraken version 3.0.13 (PageXml)
description: Source: https://www.nakala.fr/10.34847/nkl.73b6t1n2
description: Source: https://www.nakala.fr/10.34847/nkl.e905tdea
description: Relation: https://lamop.hypotheses.org/
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
Radiation-induced surge of macrophage foam cell formation, oxidative damage, and cytokine release is attenuated by a nanoformulation of curcumin
Creators: name: Behrooz Soltani
name: Bodaghabadi, Narges
name: Ghaemi, Nasser
name: Sadeghizadeh, Majid
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer

description: Purpose: We examined the potential of a dendrosomal nanoformulation of curcumin (DNC) for intervention of ionizing radiation (IR)-induced damage (particularly leading to atherosclerosis), employing an irradiated THP-1 macrophage model. Materials and methods: Differentiated THP-1 macrophages were irradiated and treated with curcumin or DNC nanoformulation (and oxidized low density lipoprotein, ox-LDL, to promote foam cells). Chemical, biochemical, and genetics tools including viability and apoptosis, multiple ELISA, real-time PCR, Western blotting, enzyme activity, and fluorimetry assays were employed to illustrate IR damage as well as the DNC intervention potential. Results: DNC per se at 10 μM exerted no cytotoxic effects on macrophages. However, it caused apoptosis in 2 Gy-irradiated macrophages which were treated with ox-LDL, chiefly through a caspase-dependent pathway involving caspase-3. Concurrently, 10 μM DNC prevented the IR-induced rise in lipid accumulation (72% decrease compared to IR control, p p p p p Conclusions: DNC treatment suppresses IR-induced oxidative damage, inflammation, and foam cell formation in macrophages through multiple mechanisms.
Neglected dynamics and spatial dependence on panel data: consequences for convergence of the usual static model estimators
Creators: name: Pirotte, Alain
name: Mur, Jesús
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Plant Biology

description: Neglected dynamics and spatial dependence on panel data: consequences for convergence of the usual static model estimators. Spatial Economic Analysis. This article assumes that the estimated model is static, whereas the true model is an autoregressive distributed lag error components model including spatial dependence on the disturbances. We derive the probability limits of the ordinary least squares (OLS), Between and Within estimators of a static model on panel data. The results show that asymptotic biases of these estimators vary mainly according to the degree of spatial autocorrelation, the unobservable individual heterogeneity and the data generating process (DGP) of the explanatory variable. The probability limit of the Between estimator converges to the long-run effects, particularly when the individual unobserved heterogeneity is large, when compared with the idiosyncratic error term, and/or there is a strong time dynamic in the regressors. The interpretation is more contrasted for the OLS and Within estimators. The former can be associated under very restrictive conditions with the long-run effects; the latter with the short-run effects.
Safety of tapentadol compared with other opioids in chronic pain treatment: network meta-analysis of randomized controlled and withdrawal trials
Creators: name: Freynhagen, R
name: Elling, C
name: Radic, T
name: Sohns, M
name: Liedgens, H
name: James, D
name: McCool, R
name: Edwards, M
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To assess the relative safety of oral tapentadol PR and other opioid analgesics for moderate or severe chronic pain in adults, we conducted a systematic review and network meta-analysis (NMA). Methods: A systematic review was conducted to identify randomized controlled trials (RCTs) and randomised withdrawal trials of tapentadol with other WHO stage II and III opioid analgesics in patients with moderate or severe chronic pain. Searches were conducted in MEDLINE, EMBASE, PubMed, Cochrane databases and trial registries. Feasibility assessment evaluated the trials’ suitability for NMA. Outcomes assessed were overall AEs, overall serious adverse events, constipation, nausea, dizziness, somnolence, headache, and discontinuation due to AEs. Randomized withdrawal trials were analysed separately to other RCTs. Results: Searches conducted in April 2019 identified 16,604 records. Following screening and feasibility assessment, 29 RCTs and 19 randomized withdrawal trials were identified and included in the NMA. Consistent with existing research, evidence from RCTs suggested that tapentadol is associated with relatively lower odds of adverse events occurring than most active comparators. The withdrawal trial data were less clear, with higher uncertainty around the results, and results that appear to contradict the RCT evidence. There are a number of trial design factors that may be affecting these results. Conclusions: RCT evidence suggests that tapentadol can be a useful treatment option for patients suffering from chronic pain and in need of an opioid analgesic. Opioids should be prescribed by a qualified physician only after other analgesics have been considered, taking side effects and misuse risk into account.
On the Battle of Ardderyd. , LL.D., F.R.S.E., With Plan and description of the earthworks at Arthuret by T. H. Hodgson,
Creators: name: Barnes, Henry
name: Hodgson
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 8, 236-248
title: OFROM: interview avec unine11b04m
Creators: name: Delafontaine, François
name: Beuret, Sylvine
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.29ee6ptc.v2#79326cbe200378b4178f8415de83c5373ef5c325
Supplementary Material for: The Use of the Linear Mixed Model in Human Genetics
Creators: name: Dandine-Roulland, C.
name: Perdry H
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: We give a short but detailed review of the methods used to deal with linear mixed models (restricted likelihood, AIREML algorithm, best linear unbiased predictors, etc.), with a few original points. Then we describe three common applications of the linear mixed model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability estimates, and correction for population stratification in genome-wide association studies. We also consider the performance of best linear unbiased predictors for prediction in this context, through a simulation study for rare variants in a short genomic region, and through a short theoretical development for genome-wide data. For each of these applications, we discuss the relevance and the impact of modeling genetic effects as random effects.
Neglected Dynamics and Spatial Dependence on Panel Data: Consequences for Convergence of the Usual Static Model Estimators
Creators: name: Pirotte, Alain
name: Mur, Jesús
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: This article assumes that the estimated model is static, whereas the true model is an autoregressive distributed lag error components model including spatial dependence on the disturbances. We derive the probability limits of the ordinary least squares (OLS), Between and Within estimators of a static model on panel data. The results show that asymptotic biases of these estimators vary mainly according to the degree of spatial autocorrelation, the unobservable individual heterogeneity and the data generating process (DGP) of the explanatory variable. The probability limit of the Between estimator converges to the long-run effects, particularly when the individual unobserved heterogeneity is large, when compared with the idiosyncratic error term, and/or there is a strong time dynamic in the regressors. The interpretation is more contrasted for the OLS and Within estimators. The former can be associated under very restrictive conditions with the long-run effects; the latter with the short-run effects.