cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Contribution of Anoctamins to Cell Survival and Cell Death
Creators: name: Kunzelmann, Karl
name: Ousingsawat, Jiraporn
name: Benedetto, Roberta
name: Cabrita, Ines
name: Schreiber, Rainer
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: anoctamin; ANO1; ANO6; TMEM16A; TMEM16F; cancer; proliferation; apoptosis; Ca2+ signaling; inflammation
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1, TMEM16A) was known as DOG1, a marker protein for gastrointestinal stromal tumors (GIST). Meanwhile, ANO1 has been examined in more detail, and the role of ANO1 in cell proliferation and the development of different types of malignomas is now well established. While ANO5, ANO7, and ANO9 may also be relevant for growth of cancers, evidence has been provided for a role of ANO6 (TMEM16F) in regulated cell death. The cellular mechanisms by which anoctamins control cell proliferation and cell death, respectively, are just emerging; however, the pronounced effects of anoctamins on intracellular Ca2+ levels are likely to play a significant role. Recent results suggest that some anoctamins control membrane exocytosis by setting Ca2+i levels near the plasma membrane, and/or by controlling the intracellular Cl− concentration. Exocytosis and increased membrane trafficking induced by ANO1 and ANO6 may enhance membrane expression of other chloride channels, such as CFTR and volume activated chloride channels (VRAC). Notably, ANO6-induced phospholipid scrambling with exposure of phosphatidylserine is pivotal for the sheddase function of disintegrin and metalloproteinase (ADAM). This may support cell death and tumorigenic activity of IL-6 by inducing IL-6 trans-signaling. The reported anticancer effects of the anthelminthic drug niclosamide are probably related to the potent inhibitory effect on ANO1, apart from inducing cell cycle arrest through the Let-7d/CDC34 axis. On the contrary, pronounced activation of ANO6 due to a large increase in intracellular calcium, activation of phospholipase A2 or lipid peroxidation, can lead to ferroptotic death of cancer cells. It therefore appears reasonable to search for both inhibitors and potent activators of TMEM16 in order to interfere with cancer growth and metastasis.
Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus
Creators: name: Enkirch, Theresa
name: Severi, Ettore
name: Vennema, Harry
name: Thornton, Lelia
name: Dean, Jonathan
name: Borg, Maria-Louise
name: Ciccaglione, Anna Rita
name: Bruni, Roberto
name: Christova, Iva
name: Ngui, Siew Lin
name: Balogun, Koye
name: Němeček, Vratislav
name: Kontio, Mia
name: Takács, Mária
name: Hettmann, Andrea
name: Korotinska, Rita
name: Löve, Arthur
name: Avellón, Ana
name: Muñoz-Chimeno, Milagros
name: De Sousa, Rita
name: Janta, Denisa
name: Epštein, Jevgenia
name: Klamer, Sofieke
name: Suin, Vanessa
name: Aberle, Stephan W.
name: Holzmann, Heidemarie
name: Mellou, Kassiani
name: Ederth, Josefine Lundberg
name: Sundqvist, Lena
name: Roque-Afonso, Anne-Marie
name: Filipović, Sanja Kurečić
name: Poljak, Mario
name: Vold, Line
name: Stene-Johansen, Kathrine
name: Midgley, Sofie
name: Fischer, Thea Kølsen
name: Faber, Mirko
name: Wenzel, Jürgen J.
name: Takkinen, Johanna
name: Leitmeyer, Katrin
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: European Union; HAV; capacity building; foodborne diseases; hepatitis A virus; sequence analysis; surveys and questionnaires
subject: 610 Medizin

description: Introduction: Sequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive. Aim: The objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods. Results: Of 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths. Conclusions: While HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.
Transport through quantum spin Hall insulator/metal junctions in graphene ribbons
Creators: name: Prada, Elsa
name: Metalidis, Georgo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Quantum spin Hall insulator/metal interfaces are formed in graphene ribbons with intrinsic spin-orbit coupling by selectively doping two regions creating a potential step. For a clean graphene ribbon, the transmission of the topological edge states through a n-n or p-p junction is perfect irrespective of the ribbon termination, width, and potential step parameters due to the orthogonality of incoming and outgoing edge channels. This is shown numerically for an arbitrary crystallographic orientation of the ribbon and proven analytically for zigzag and metallic armchair boundary conditions. In disordered ribbons, the orthogonality between left- and right-movers is in general destroyed and backscattering sets in. However, transmission approaches one by increasing the ribbon's width, even in the presence of strong edge roughness.
description: 12 pages, 9 figures. Order of authors exchanged. Published version in the special issue of the Journal of Computational Electronics: "Electronic transport in graphene nanostructures and devices"
Posttraumatic stress disorder after minor trauma – A prospective cohort study
Creators: name: Angerpointner, Katharina
name: Weber, Stefanie
name: Tschech, Karen
name: Schubert, Hannah
name: Herbst, Tanja
name: Ernstberger, Antonio
name: Kerschbaum, Maximilian
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: Posttraumatic stress disorder PTSD Anxiety disorder Minor trauma Road traffic accident
subject: 610 Medizin

description: Background: Posttraumatic stress disorder (PTSD) can arise as a reaction to a traumatic experience. While many data concerning PTSD in severely injured patients are available, little is known about this disease in slightly injured patients after road traffic accidents. It is rather assumed that PTSD does not exist after objectively slight injuries. Methods: In total, 36 patients (Injury Severity Score < 16) after road traffic accidents were included in this prospective cohort study. Next to demographic and accident-specific data, the PDI (Peritraumatic Distress Inventory: individual experienced distress directly during or immediately after the traumatic event), THQ (Trauma History Questionnaire) and the BDI-II (Beck Depression Inventory-II: self-report measurement tool to examine the severity of depression) were assessed immediately after trauma (t0). Six weeks (t1) and 3 months (t2) after trauma the Impact of Event Scale – Revised (IES-R), a screening instrument for PTSD, and the BDI-II were collected. Results: Overall 2 patients showed critical measurement values in IES-R after 6 weeks. A strong correlation between PDI and IES-R at t1 and t2 could be detected (p < 0.05). Furthermore, a significant correlation of BDIII and IES-R after 6 weeks and 3 months was found (p < 0.05). Neither age or sex showed a significant correlation to IES-R (p≥0.05). Conclusion: The present study showed that symptoms of PTSD can also occur after minor trauma. Especially high peritraumatic distress is associated with developing a PTSD. The occurrence of PTSD should be considered not only in severely injured patients, but also in slightly injured patients after road traffic accidents.
description: kostenfreier Zugang zum Volltext (final version) beim Verlag über o. a. personalisierten Link (https://authors.elsevier.com/c/1a2-c15pGbzReh) - dieser ist allerdings nur bis 31.12.2019 gültig!!!
title: Стратегия развития промышленно-туристического кластера на базе завода «Алкон»
Creators: name: Донкина, Мария
name: Кузьменко, Светлана
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: В статье раскрываются принципы архитектурно-градостроительного формирования и развития туристического кластера на базе одного из старейших предприятий в России по выпуску русского крепкого алкоголя, основанного в конце XIX века в городе Великий Новгород. Причиной обращения к данной теме послужила мировая и отечественная тенденция развития новых площадок и креативных пространств на базе предприятий, в силу разных причин, утрачивающих свою привлекательность в стремительно развивающейся городской среде. Развитие промышленного туризма при помощи так называемого «эффекта места» позволяет предпринимателям ознакомить гостей и жителей города с их производством, развивая тем самым бренд города. Кластер ориентирован на использование потенциала территории и повышение туристической привлекательности. В
результате исследован опыт проектирования креативных пространств, предприятий в данном регионе и выявлены перспективные направления промышленных зон.
Recent advances in application of pyridinium chlorochromate (PCC) in organic synthesis
Creators: name: Mommahed Heravi, Majid
name: Fazeli, Azadeh
name: Faghihi, Zeinab
Publisher: name: figshare
Year: 2022
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30701 Quantum Chemistry
subject: 39904 Organometallic Chemistry
subject: Organic Chemistry
subject: 30502 Natural Products Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30504 Organic Green Chemistry
subject: 30303 Optical Properties of Materials

description: Pyridinium chlorochromate (PCC) is an important reagent in organic synthesis used primarily for the selective oxidation of alcohols to give carbonyl compounds. Although a variety of related compounds are known with similar reactivity, PCC offers exclusively the advantage of the selective oxidation of alcohols to aldehydes, whereas many other reagents were less selective. Disadvantages of using PCC are the tedious reaction workup and its toxicity, very well compensated by selective oxidation, observed using this reagent as an oxidant. This useful oxidant was first synthesized and used by E. J. Corey and J. William Suggs in 1972.
The issue of avoidance : information avoidance in the context of personal health concerns
Creators: name: Addison, Colleen Victoria
Publisher: name: University of British Columbia
Year: 2017

description: Information is increasingly available at the touch of a button, and yet limits are still present in the ability and willingness of individuals to access that information. These limits can result in information avoidance, a phenomenon in which individuals prefer not to seek or be exposed to information. Nowhere is this phenomenon more evident and more problematic than in health, where information has been linked to better health outcomes, and where the consumer health movement has shifted the responsibility of health information seeking from healthcare professionals to patients. This dissertation examines such health information avoidance, looking in particular at the mechanisms that constitute this phenomenon, and the affective, personality, and information source factors that influence it. Two studies were performed, the first an online survey using the crowdsourcing platform Mechanical Turk for recruitment, and the second a user study in which participants interacted with health information and were then interviewed. Both studies also employed scales such as the Need for Cognition scale, the Threatening Medical Situations Inventory (examining monitoring and blunting styles), and the Positive and Negative Affect short scale. Results indicate that very few people are willing to report practising complete information avoidance. However, numerous participants reported avoiding some information, often through filtering mechanisms such as self-regulation and delegation. This evidence of partial avoidance suggests that information avoidance can be located on a continuum of information seeking behaviours, rather than existing as a simple negation of information seeking. Significant factors that influence the practice of information avoidance were found to include affect such as fear, disgust, and disinterest, all factors that can indicate a threat to the participant. While the personality and information source factors tested were also influential, this work found that for these participants, affective factors often functioned as a primary influence. This work indicates that health information avoidance is a situation-dependent information behaviour, rather than primarily a personality trait as previously claimed. As such, it should be included in models that depict people’s general behavioural patterns with regard to information, such as Wilson’s (1999) General Model of Information Seeking and Johnson’s (1997) Comprehensive Model of Information Seeking.
Boundary effects on the local density of states of one-dimensional Mott insulators and charge density wave states
Creators: name: Schuricht, Dirk
name: Essler, Fabian H. L.
name: Jaefari, Akbar
name: Fradkin, Eduardo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We determine the local density of states (LDOS) for spin-gapped one-dimensional charge density wave (CDW) states and Mott insulators in the presence of a hard-wall boundary. We calculate the boundary contribution to the single-particle Green function in the low-energy limit using field theory techniques and analyze it in terms of its Fourier transform in both time and space. The boundary LDOS in the CDW case exhibits a singularity at momentum 2kF, which is indicative of the pinning of the CDW order at the impurity. We further observe several dispersing features at frequencies above the spin gap, which provide a characteristic signature of spin-charge separation. This demonstrates that the boundary LDOS can be used to infer properties of the underlying bulk system. In presence of a boundary magnetic field mid-gap states localized at the boundary emerge. We investigate the signature of such bound states in the LDOS. We discuss implications of our results on STM experiments on quasi-1D systems such as two-leg ladder materials like Sr14Cu24O41. By exchanging the roles of charge and spin sectors, all our results directly carry over to the case of one-dimensional Mott insulators.
description: 28 pages
Hamiltonian analysis of non-projectable modified F(R) Hořava-Lifshitz gravity
Creators: name: Chaichian, Masud
name: Oksanen, Markku
name: Tureanu, Anca
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study a version of the recently proposed modified $F(R)$ Hořava-Lifshitz gravity that abandons the projectability condition of the lapse variable. We discovered that the projectable version of this theory has a consistent Hamiltonian structure, and that the theory has interesting cosmological solutions which can describe the eras of accelerated expansion of the universe in a unified manner. The usual Hořava-Lifshitz gravity is a special case of our theory. Hamiltonian analysis of the non-projectable theory, however, shows that this theory has serious problems. These problems are compared with those found in the original Hořava-Lifshitz gravity. A general observation on the structure of the Poisson bracket of Hamiltonian constraints in all theories of the Hořava-Lifshitz type is made: in the resulting tertiary constraint the highest order spatial derivative of the lapse $N$ is always of uneven order. Since the vanishing of the lapse (N=0) is required by the preservation of the Hamiltonian constraints under time evolution, we conclude that the non-projectable version of the theory is physically inconsistent.
description: LaTeX 18 pages. v3: Some errors have been corrected
Molecular dynamics simulation of UO2 nanocrystals melting under isolated and periodic boundary conditions
Creators: name: Boyarchenkov, A. S.
name: Potashnikov, S. I.
name: Nekrasov, K. A.
name: Kupryazhkin, A. Ya.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Melting of uranium dioxide (UO2) nanocrystals has been studied by molecular dynamics (MD) simulation. Ten recent and widely used sets of pair potentials were assessed in the rigid ion approximation. Both isolated (in vacuum) and periodic boundary conditions (PBC) were explored. Using barostat under PBC the pressure dependences of melting point were obtained. These curves intersected zero near -20 GPa, saturated near 25 GPa and increased nonlinearly in between. Using simulation of surface under isolated boundary conditions (IBC) recommended melting temperature and density jump were successfully reproduced. However, the heat of fusion is still underestimated. These melting characteristics were calculated for nanocrystals of cubic shape in the range of 768-49 152 particles (volume range of 10-1000 nm^3). The obtained reciprocal size dependences decreased nonlinearly. Linear and parabolic extrapolations to macroscopic values are considered. The parabolic one is found to be better suited for analysis of the data on temperature and heat of melting.
description: 19 pages, 15 figures, 4 tables
Mindfulness-based intervention for tennis players: a quasi-experimental pilot study
Creators: name: Hoja, Sabine
name: Jansen, Petra
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: 796 Sport

description: Objectives Mindfulness-based interventions in the context of sports have been shown to result in higher mindfulness scores and improved physiological and psychological parameters. The goal of this pilot study was to investigate the effects of a newly developed seven-session mindfulness-based intervention, mindful emotions, on German tennis players. Methods The study was conducted in a pre–post test design with an intervention and a control group. Before and after the mindfulness-based stress reduction training the following dependent measurements were assessed: athletic performance (serve accuracy) and psychological performance indicators (mindfulness, stress and competition anxiety). Results The results indicate a better performance of the intervention group for the difference scores between post-test and pre-test in one of the sport-related anxiety factors, the concentration disturbances index. Conclusion In order to further investigate the effects of this mindfulness-based intervention in competitive sports, additional studies with a larger number of participants have to follow.
Sketching with Hardware: A Course for Teaching Interactive Hardware Prototyping to Computer Science Students
Creators: name: Schmid, Andreas
name: Wimmer, Raphael
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: tangible interaction, teaching, prototyping
subject: 004 Informatik

description: Sketching with Hardware is an undergraduate university course with the goal to teach students how to build prototypes for tangible user interfaces. Goals of this course are to create awareness for tangible interaction among students and prepare them to realize advanced projects like bachelor's and master's theses in this field. In this paper, authors share their experience teaching the concepts of tangible interaction, electronics and prototyping to computer science students in a two week course. The course's content, structure and goals are explained, and needed material and infrastructure are described. The long-term effect of the course has been evaluated by conducting a survey among former participants.
Lagrangian blow-ups, blow-downs, and applications to real packing
Creators: name: Rieser, Antonio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics

description: Given a symplectic manifold (M, ω) and a Lagrangian submanifold L, we construct versions of the symplectic blow-up and blow-down which are defined relative to L. Furthermore, we show that if M admits an anti-symplectic involution ϕ and we blow-up an appropriately symmetric embedding of symplectic balls, then there exists an anti-symplectic involution on the blow-up as well. We derive a homological condition which determines when the topology of a real Lagrangian surface L = Fix(ϕ) changes after a blow down, and we use these constructions to study the real packing numbers and packing stability for real, rank-1 symplectic four manifolds which are non-Seiberg-Witten simple.
description: 66 pages, 1 figure
The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT‐HFpEF): Rationale and design
Creators: name: James, Stefan
name: Pol, Tymon
name: Karlström, Patric
name: Fu, Michael
name: Dahlström, Ulf
name: DeVore, Adam D.
name: Oldgren, Jonas
name: Desvigne‐Nickens, Patrice
name: Nygren, Magnus
name: Fleg, Jerome L.
name: Peterson, Eric D.
name: Pitt, Bertram
name: Hage, Camilla
name: Anstrom, Kevin J.
name: Lund, Lars H.
name: Sundström, Johan
name: Östlund, Ollie
name: Held, Claes
name: Fudim, Marat
name: Yang, Song
name: Sapp, Shelly
name: Aaronson, Keith D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: AIMS: Benefits of mineralocorticoid receptor antagonists (MRAs) in heart failure with preserved and mildly reduced ejection fraction (HFpEF/HFmrEF) have not been established. Conventional randomized controlled trials are complex and expensive. The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF) is a unique pragmatic registry-based randomized controlled trial.
METHODS: SPIRRIT-HFpEF is a multicentre, prospective, randomized, open-label, blinded endpoint trial conducted on platforms in the Swedish Heart Failure Registry (SwedeHF) and the United States (US) Trial Innovation Network. Patients with HFpEF/HFmrEF are randomized 1:1 to spironolactone (or eplerenone) in addition to usual care, versus usual care alone. The primary outcome is total number of cardiovascular deaths and hospitalizations for heart failure. Outcomes are collected from Swedish administrative complete coverage registries and a US call centre and subsequently adjudicated. Simple eligibility criteria were based on data available in SwedeHF: heart failure as outpatient or at discharge from hospital, left ventricular ejection fraction ≥40%, N-terminal pro-B-type natriuretic peptide >300 ng/L (in sinus rhythm) or >750 ng/L (in atrial fibrillation), with pre-specified adjustment for elevated body mass index, and chronic loop diuretic use. Power and sample size assessments were based on an event-driven design allowing enrolment over approximately 6 years, and application of hazard ratios from the TOPCAT trial, Americas subset. The final sample size is expected to be approximately 2400 patients.
CONCLUSION: SPIRRIT-HFpEF will be informative on the effectiveness of generic MRAs in HFpEF and HFmrEF, and on the feasibility of conducting pragmatic and registry-based trials in heart failure and other chronic conditions.
Applying Voting Methods in User Research
Creators: name: Sageder, Julia
name: Demleitner, Ariane
name: Irlbacher, Oliver
name: Wimmer, Raphael
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: Likert scales, Likert-type items, ranking, Condorcet voting, Borda count, Schulze method, voting methods
subject: 004 Informatik

description: In usability practice, it is often necessary to find a ‘best’ solution that is most suitable for most users. A common way to do this is to present multiple alternatives to a group of users and let them express their preferences. However, integrating many subjective ratings into one generally valid rating is non-trivial. For such data, voting methods from the field of computational social choice might prove useful. In order to investigate their suitability, we conducted an experiment where participants had to complete a pointing task using four different mouse acceleration values and rank the perceived performance of each option via Likert-type items and also by ranking them. For generating an overall ranking, we calculated arithmetic mean and median as well as Borda count and Schulze method for each of the response sets. All methods resulted in nearly the same overall ranking of options which suggests that they might be equally useful for generating consensus on a ‘best’ option.
title: "Statua di fanciullo con brocca", arte romana, inv. CLXXX (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Ciccarello, Giulia
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di

Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Social dynamics and nationhood in employment politics in the Trepça mining complex in Socialist Kosovo (1960s)
Creators: name: Troch, Pieter
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: Kosovo, Socialist Yugoslavia, employment politics, Trepça, nationhood
subject: 940 Geschichte Europas

description: This article analyses the interconnection of socio-economic divisions and nationhood in Socialist Kosovo through a case-study of employment politics in the Trepça mining complex during the 1960s. The article first describes the shifting cadre politics in Trepça, which aimed to increase the degree of skills of the work collective and to address the dramatic under-representation of Albanians in management and specialist positions. It then analyses the departure of Serb and Montenegrin specialists from the enterprise and the internal dispute over the proportional relevance of socio-economic and national grounds for this trend. The second half of the article situates these developments against two levels of social division in the enterprise: vertical social divisions between manual production workers and specialist cadres and horizontal divisions at the top management level. The article argues that the divisions between low-skilled production workers and management personnel was not politically relevant. Such vertical social divisions were depoliticised and denationalised. The outspoken national dimension of cadre politics for specialist personnel and the pluralist tendencies in the management culture of Yugoslav enterprises during the late 1960s, on the other hand, nationalised and politicised the competition between a new generation of Albanian technically-schooled specialists and the predominantly Serb, politically-appointed managers in function.
description: Embargoed access: Nach Embargo automatisch öffentlich ab 1. Mai 2020
Unitarity in periodic potentials: a renormalization group analysis
Creators: name: Nikolic, Predrag
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We explore the universal properties of interacting fermionic lattice systems, mostly focusing on the development of pairing correlations from attractive interactions. Using renormalization group we identify a large number of fixed points and show that they correspond to resonant scattering in multiple channels. Pairing resonances in finite-density band insulators occur between quasiparticles and quasiholes living at different symmetry-related wavevectors in the Brillouin zone. This allows a BCS-BEC crossover interpretation of both Cooper and particle-hole pairing. We show that in two dimensions the run-away flows of relevant attractive interactions lead to charged-boson-dominated low energy dynamics in the insulating states, and superfluid transitions in bosonic mean-field or XY universality classes. Analogous phenomena in higher dimensions are restricted to the strong coupling limit, while at weak couplings the transition is in the pair-breaking BCS class. The models discussed here can be realized with ultra-cold gases of alkali atoms tuned to a broad Feshbach resonance in an optical lattice, enabling experimental studies of pairing correlations in insulators, especially in their universal regimes. In turn, these simple and tractable models capture the emergence of fluctuation-driven superconducting transitions in fermionic systems, which is of interest in the context of high temperature superconductors.
description: 16 pages, 6 figures, published version
Enhancing credibility of digital evidence through provenance-based incident response handling
Creators: name: Englbrecht, Ludwig
name: Langner, Gregor
name: Pernul, Günther
name: Quirchmayr, Gerald
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: Incident Response, Digital Forensics, Digital evidence credibility, Data Provenance, Cyber Security, Evidence collection
subject: 050 Zeitschriften, fortlaufende Sammelwerke

description: Digital forensics are becoming increasingly important for the investigation of computer-related crimes, white-collar crimes and massive hacker attacks. After an incident has been detected an appropriate incident response is usually initiated with the aim to mitigate the attack and ensure the recovery of the IT systems. Digital Forensics pursues the goal of acquiring evidence that will stand up in court for sentencing and sometimes opposes contradicting objectives of incident response approaches. The concept presented here provides a solution to strengthen the credibility of digital evidence during actions related to incident response. It adapts an approach for data provenance to accurately track the transformation of digital evidence. For this purpose, the affected system and the incident response systems are equipped with a whole system data provenance capturing mechanism and then data provenance is captured simultaneously during an incident response. Context information about the incident response is also documented. An adapted algorithm for sub-graph detection is used to identify similarities between two provenance graphs. By applying the proposed concept to a use case, the advantages are demonstrated and possibilities for further development are presented.
description: Canterbury, CA, United Kingdom — August 26 - 29, 2019
Mechanistic insights into retigabine modulation of neuronal KCNQ channels
Creators: name: Kim, Robin Yongkyu
Publisher: name: University of British Columbia
Year: 2018

description: Epilepsy is among the most prevalent neurological disorders, affecting approximately 1% of the human population. There are many types of epilepsies, with diverse aetiologies, and many therapies that target ion channels as a means to combat neuronal hyper-excitability. However, most anti-epileptic drugs today target a limited number of ion channel types, mainly voltage-gated sodium and calcium channels. Retigabine is a recently approved anti-epileptic drug that operates through a novel mechanism of activating voltage-gated potassium channels. Previous research has established neuronal KCNQ channels as the therapeutic target of retigabine. However, detailed insights regarding the molecular mechanisms of retigabine action are lacking, such as its mode of binding, the factors underlying its ability to stabilize channel opening, and the stoichiometry of its action. A lack of such knowledge hampers the development of more potent and specific channel openers devoid of side effects associated with this first-generation drug. The work presented in this thesis utilizes various research techniques to investigate retigabine pharmacology at a molecular level. In the first objective, retigabine binding to KCNQ3 channels is investigated using unnatural amino-acid mutagenesis. The data pinpoint an essential hydrogen-bonding interaction that likely occurs between an S5 tryptophan residue and a carbonyl oxygen moiety present in most KCNQ activating drugs, providing the highest resolution understanding of the retigabine pharmacophore to date. In the second objective, voltage-clamp fluorometry is used to track conformational changes of the voltage-sensing domain of KCNQ3 channels. The data illustrate a network of interactions between the voltage-sensing and ion conducting regions of the channel protein that is dependent on the anionic membrane phospholipid PIP2; these interactions are not only essential for channel function, but also for retigabine binding to modulate channel voltage sensing downstream of binding in the pore domain. Finally, using iii concatenated KCNQ3 constructs to express channels with variable stoichiometry of retigabine binding sites, we demonstrate that a minimum of one retigabine sensitive channel subunit is required for functional pharmacological effects. Overall, this work provides novel insights applicable to the development of retigabine derivatives with greater therapeutic impact, and improves our understanding of lipid and drug regulation of KCNQ channels.
A (1+1) dimensional example of Quarkyonic matter
Creators: name: Kojo, Toru
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze the (1+1) dimensional QCD (QCD_2) at finite density to consider a number of qualitative issues: confinement in dense quark matter, the chiral symmetry breaking near the Fermi surface, the relation between chiral spirals and quark number density, and a possibility of the spontaneous flavor symmetry breaking. We argue that while the free energy is dominated by perturbative quarks, confined excitations at zero density can persist up to high density. So quark matter in QCD$_2$ is an example of Quarkyonic matter. The non-Abelian bosonization and associated charge-flavor-color separation are mainly used in order to clarify basic structures of QCD_2 at finite density.
description: 32 pages, 9 figures, published version
Class Schema Evolution for Persistent Object-Oriented Software: Model, Empirical Study, and Automated Support
Creators: name: Piccioni, Marco
name: Oriol, Manuel
name: Meyer, Bertrand
Publisher: name: arXiv
Year: 2011
Subjects: subject: Software Engineering (cs.SE)
subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: With the wide support for object serialization in object-oriented programming languages, persistent objects have become common place and most large object-oriented software systems rely on extensive amounts of persistent data. Such systems also evolve over time. Retrieving previously persisted objects from classes whose schema has changed is however difficult, and may lead to invalidating the consistency of the application. The ESCHER framework addresses these issues through an IDE-integrated approach that handles class schema evolution by managing versions of the code and generating transformation functions automatically. The infrastructure also enforces class invariants to prevent the introduction of potentially corrupt objects. This article describes a model for class attribute changes, a measure for class evolution robustness, four empirical studies, and the design and implementation of the ESCHER system.
description: 14 pages, to appear in IEEE Transactions on Software Engineering (TSE)
The superfluid fountain effect in a Bose-Einstein condensate
Creators: name: Karpiuk, Tomasz
name: Gremaud, Benoit
name: Miniatura, Christian
name: Gajda, Mariusz
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We consider a simple experimental setup, based on a harmonic confinement, where a Bose-Einstein condensate and a thermal cloud of weakly interacting alkali atoms are trapped in two different vessels connected by a narrow channel. Using the classical field approximation, as described in J. Phys. B 40, R1 (2007) and optimized in Phys. Rev. A 81, 013629 (2010) for an arbitrary trapping potential, we theoretically investigate the analog of the celebrated superfluid helium fountain effect. We show that this thermo-mechanical effect might indeed be observed in this system. By analyzing the dynamics of the system, we are able to identify the superfluid and normal components of the flow as well as to distinguish the condensate fraction from the superfluid component. We show that the superfluid component can easily flow from the colder vessel to the hotter one while the normal component is practically blocked in the latter.
description: 13 pages, 11 figures, 3 tables
Blood-based biomarkers of asthma
Creators: name: Yang, Chen Xi
Publisher: name: University of British Columbia
Year: 2018

description: Asthma is a chronic inflammatory airway disorder characterized by reversible airway obstruction and hyperresponsiveness. It affects more than 300 million people worldwide but remains poorly understood. Asthma can be induced by a variety triggers, including allergens, substances found in the workplace, cold air and exercises, and greatly diminishes the life quality of patients. In this thesis, I investigated two major categories of asthma: allergic asthma and occupational asthma. Two types of response are involved in allergic asthma. While 50% of the affected individuals only develop an acute early asthmatic response (EAR), the other individuals develop both the EAR and a chronic late asthmatic response (LAR). Those individuals who present an isolated EAR are classified as early responders (ERs) and individuals who present both the EAR and the LAR are classified as dual responders (DRs). In our study, patients with mild asthma were challenged with specific allergens and their blood was collected prior to the challenge. By measuring the gene expression and the protein levels of complement and coagulation molecules, I demonstrated that the complement and coagulation system may play a role in the LAR of allergic asthma. Occupational asthma is caused by sensitivity to specific molecules found in the working environment. Western red cedar asthma (WRCA) is the most common form of occupational asthma in the Pacific Northwest region of North America, including British Columbia. It is due to sensitivity to a low molecular weight molecule, plicatic acid (PA), found in the dust of western red cedar wood. The current diagnosis of WRCA is through multiple bronchial challenges, which are time-consuming, complicated and expensive. Blood samples were collected from individuals who were suspected to have WRCA prior to the bronchial challenges. Gene expression was measured using the NanoString platform. Using a pathway-directed approach of random forest and leave-one-out cross-validation, I identified and validated a blood-based two-gene biomarker panel which may help distinguish patients with WRCA from those with asthma due to non-western red cedar causes at baseline. Having such a biomarker panel may greatly simplify the current diagnosis of WRCA by way of a simple blood test.
Static spectroscopy of a dense superfluid
Creators: name: Villerot, Sophie
name: Castaing, Bernard
name: Chevillard, Laurent
Publisher: name: arXiv
Year: 2011
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Dense Bose superfluids, as HeII, differ from dilute ones by the existence of a roton minimum in their excitation spectrum. It is known that this roton minimum is qualitatively responsible for density oscillations close to any singularity, such as vortex cores, or close to solid boundaries. We show that the period of these oscillations, and their exponential decrease with the distance to the singularity, are fully determined by the position and the width of the roton minimum. Only an overall amplitude factor and a phase shift are shown to depend on the details of the interaction potential. Reciprocally, it allows for determining the characteristics of this roton minimum from static "observations" of a disturbed ground state, in cases where the dynamics is not easily accessible. We focus on the vortex example. Our analysis further shows why the energy of these oscillations is negligible compared to the kinetic energy, which limits their influence on the vortex dynamics, except for high curvatures.
description: 14 pages, 4 figures, extended version, published in J. Low Temp. Phys
Recent Neutrino Data and Type III Seesaw with Discrete Symmetry
Creators: name: Ahn, Y. H.
name: Kim, C. S.
name: Oh, Sechul
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In light of the recent neutrino experiment results from Daya Bay and RENO Collaborations, we study phenomenology of neutrino mixing angles in the Type III seesaw model with an discrete $A_4 \times Z_2$ symmetry, whose spontaneously breaking scale is much higher than the electroweak scale. At tree level, the tri-bimaximal (TBM) form of the lepton mixing matrix can be obtained from leptonic Yukawa interactions in a natural way. We introduce all possible effective dimension-5 operators, invariant under the Standard Model gauge group and $A_4 \times Z_2$, and explicitly show that they induce a deviation of the lepton mixing from the TBM mixing matrix, which can explain a large mixing angle $θ_{13}$ together with small deviations of the solar and atmospheric mixing angles from the TBM. Two possible scenarios are investigated, by taking into account either negligible or sizable contributions from the light charged lepton sector to the lepton mixing matrix. Especially it is found in the latter scenario that all the neutrino experimental data, including the recent best-fit value of $θ_{13} = 8.68^{\circ}$, can be accommodated. The leptonic CP violation characterized by the Jarlskog invariant $J_{CP}$ has a non-vanishing value, indicating a signal of maximal CP violation.
description: 28 pages, 7 figures and references are added
Oscillations in Gas-grain Astrochemical Kinetics
Creators: name: Dufour, Gwenaëlle
name: Charnley, Steven B.
name: Lindberg, Johan E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have studied gas-grain chemical models of interstellar clouds to search for nonlinear dynamical evolution. A prescription is given for producing oscillatory solutions when a bistable solution exists in the gas-phase chemistry and we demonstrate the existence of limit cycle and relaxation oscillation solutions. As the autocatalytic chemical processes underlying these solutions are common to all models of interstellar chemistry, the occurrence of these solutions should be widespread. We briefly discuss the implications for interpreting molecular cloud composition with time-dependent models and some future directions for this approach.
description: 9 pages, 3 figures, 1 table
A Prototypical Photo Sorting Study Design for Comparing Interaction Styles
Creators: name: Hahn, Jürgen
name: Wimmer, Raphael
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: sorting task, user study, user interfaces, digital vs. physical
subject: 004 Informatik

description: We discuss a first version of a extensible study design for a generic image-sorting task. It allows for comparing qualitative and quantitative properties of different interaction styles (e.g., direct manipulation, CLI, tangible interaction), input modalities (e.g., mouse vs. touch screen), output modalities, and UI implementations. Therefore, the study design may be of use for designing reproducible and replicable studies. Study participants are asked to sort a set of 27 photos into five categories where each of the photos depict one distinct topic belonging to only one of the categories. We conducted a first pilot study using this design, comparing a desktop GUI, an interactive tabletop, and physical photos. Task completion time was significantly lower when sorting physical photos than in the other two conditions. The study results may serve as a baseline and show limitations of the preliminary design.
Of Private and Social in Socialist Cities: The Individualizing Turn in Housing in a Medium-Sized City in Socialist Yugoslavia
Creators: name: Troch, Pieter
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: socialist city, Yugoslavia, social and private, housing, smaller city
subject: 940 Geschichte Europas

description: This article contributes to research on reconfiguration of social and private in socialist cities. It presents the case study of Mitrovica, a smaller and peripheral city in Socialist Yugoslavia, to compensate for the focus on big capital cities and socialist new towns in the literature. The article explores local decision-making processes leading to the upgrading of informal private housing and the parallel downgrading of social-sector housing between the 1960s and 1980s. It demonstrates the open-ended nature of socialist urban development as the processual outcome of negotiations between local actors involved in urban planning and housing strategies of individual residents within the structural framework of central-level housing policies and under-urbanization. The article argues that the individualizing discourse of urban modernity was integral to post-Second World War socialist urban development.
Two-Point Vorticity Statistics in the Inverse Turbulent Cascade
Creators: name: Friedrich, R.
name: Voßkuhle, M.
name: Kamps, O.
name: Wilczek, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We present a statistical analysis of the two-point vorticity probability density of the vorticity field generated in the inverse cascade of stationary two-dimensional turbulence.