cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ADVANCING PRE-SERVICE MATHEMATICS EDUCATION: DEVELOPING TEACHING TASK AND CONTENT KNOWLEDGE INSTRUMENTS
Creators: name: Maria Clara, Anindita Siregar
Publisher: name: hollex journal
Year: 2025
Subjects: Knowledge of Content and Teaching (KCT), Pre-Service Mathematics Teachers, Mathematics Education, Teaching Task Instruments, Lesson Planning

description: A solid understanding of subject matter is a fundamental requirement for pre-service mathematics teachers as they prepare for effective classroom instruction. To investigate their grasp of mathematical content and teaching skills, the development of valid and reliable assessment instruments is essential. This study focuses on the Knowledge of Content and Teaching (KCT) instrument as a tool to evaluate these competencies. Utilizing the Plomp model for educational design research, the study involved a systematic process of instrument development and validation. The findings indicate that the KCT instruments are valid, reliable, and appropriate for assessing pre-service teachers’ readiness in lesson planning and mathematics instruction. These results suggest that the KCT tools can play a crucial role in teacher education programs by supporting the evaluation and enhancement of pedagogical content knowledge. Future studies are recommended to explore broader applications of the instrument in various educational contexts.
ON BINAURAL SPATIALIZATION AND THE USE OF GPGPU FOR AUDIO PROCESSING
Creators: name: MAURO, DAVIDE ANDREA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: 3D recordings and audio, namely techniques that aim to create the perception of sound sources placed anywhere in 3 dimensional space, are becoming an interesting resource for composers, live performances and augmented reality. This thesis focuses on binaural spatialization techniques. We will tackle the problem from three different perspectives. The first one is related to the implementation of an engine for audio convolution, this is a real implementation problem where we will confront with a number of already available systems trying to achieve better results in terms of performances. General Purpose computing on Graphic Processing Units (GPGPU) is a promising approach to problems where a high parallelization of tasks is desirable. In this thesis the GPGPU approach is applied to both offline and real-time convolution having in mind the spatialization of multiple sound sources which is one of the critical problems in the field. Comparisons between this approach and typical CPU implementations are presented as well as between FFT and time domain approaches. The second aspect is related to the implementation of an augmented reality system having in mind an ``off the shelf'' system available to most home computers without the need of specialized hardware. A system capable of detecting the position of the listener through a head-tracking system and rendering a 3D audio environment by binaural spatialization is presented. Head tracking is performed through face tracking algorithms that use a standard webcam, and the result is presented over headphones, like in other typical binaural applications. With this system users can choose audio files to play, provide virtual positions for sources in an Euclidean space, and then listen as if they are coming from that position. If users move their head, the signals provided by the system change accordingly in real-time, thus providing the realistic effect of a coherent scene. The last aspect covered by this work is within the field of psychoacoustic, long term research where we are interested in understanding how binaural audio and recordings are perceived and how then auralization systems can be efficiently designed. Considerations with regard to the quality and the realism of such sounds in the context of ASA (Auditory Scene Analysis) are proposed.
The C4A Evaluation and the Independent Review of Sport Wales Phase 2 Impact Evaluation: Year 2 Report Thematic Studies 2016/17 “Reporting the Findings, Applying the Lessons”
Creators: name: Bolton, Nicola
name: Church, Sally
name: Dixon, Ruby
name: Frost, Mark
name: Harris, Sandra
name: Martin, Steve
name: Whittington, Liam
Publisher: name: Cardiff Metropolitan University
Year: 2022
Subjects: Sports science and exercise not elsewhere classified
Sport and leisure management

description: Year 1 of the C4A Evaluation was Case Study Focussed. Year 2 has been a Thematic focus. Themes of: Participation Governance and Partnership Value for money This Report feeds back on findings and key themes of the 3 studies Includes outputs from Project and SW Case Officer Workshops on emerging themes Opportunity to apply lessons from the Studies to the final year of the Programme
Biases in physical parameter estimates through differential lensing magnification
Creators: name: Er, Xinzhong
name: Ge, Junqiang
name: Mao, Shude
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the lensing magnification effect on background galaxies. Differential magnification due to different magnifications of different source regions of a galaxy will change the lensed composite spectra. The derived properties of the background galaxies are therefore biased. For simplicity, we model galaxies as a superposition of an axis-symmetric bulge and a face-on disk in order to study the differential magnification effect on the composite spectra. We find that some properties derived from the spectra (e.g., velocity dispersion, star formation rate and metallicity) are modified. Depending on the relative positions of the source and the lens, the inferred results can be either over- or under-estimates of the true values. In general, for an extended source at strong lensing regions with high magnifications, the inferred physical parameters (e.g. metallicity) can be strongly biased. Therefore detailed lens modelling is necessary to obtain the true properties of the lensed galaxies.
description: 5 pages, 4 figures, ApJ accepted
Warning: A global cyberattack is more likely than you think
Creators: name: Diluvio Ghamari
Publisher: name: Zenodo
Year: 2021
Subjects: cyberpandemic
cyberattack
warning
globalisation
virus
great reset
wef
world economic forum
important
global problems
prevention
discussion
attention
censorship
control
communications
internet
2030
agenda
supply-chain
electronic
electricity

description: Warning! Cyberattack! Cyberpandemic! A global cyberpandemic is more likely to happen than you think. Statement: A cyber-pandemic has a significant probability to happen and it should not be ignored. It could be false, planned, and accidental or even the three at the same time in progression, with causes and consequences, direct and indirect. It would still be a problem that someone should take in consideration and leave it in his head in case of prevention, who knows. The most probable time is whether in the nearest times, like some months, or either a decade. Something to know is that the more we approach to 2030 and over, the more big the probability. More details will come after. This global cyberattack will effect internet, electricity, communications and other electronic and non-electronic elements like supply-chains.
MEN, MASCULINITIES AND DIABETES. A QUALITATIVE RESEARCH ON THE EVERYDAY LIFE OF MEN WITH A CHRONIC ILLNESS
Creators: name: QUAGLIA, VALERIA
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: National and international epidemiological data show a general male disadvantage in health, and the dominant explanation for men?s poorer health status usually points to men?s belief and behaviours in relation to health and illness: men, it is suggested, disregard health and mismanage illness in order to fulfil social expectations around masculinity. The present research responds to a call for empirical studies that explore men?s health and illness practices not through biomedical or behavioural explanations, which tend to homogenize and oversimplify men?s experiences, rather with a critical approach that would allow to go beyond the idea that ?masculinity is dangerous to men?s health.? Masculinity is here intended not as a fixed, universal, biological trait, but rather as a configuration of practices that are accomplished in social action and, therefore, can differ according to the specific gender relations existing in different social settings. This critical perspective allowed studying men?s experiences of health and illness by taking into account also its complex relation with gender construction, but also with structural differences and relational contexts. This research explored, through the conduction of 40 in-depth interviews, the experiences of men living with an intrusive chronic illness, autoimmune diabetes. This condition requires a series of self- management practices in everyday life that could be considered as emasculating (e.g. eating healthy, body discipline and self-monitoring) and that may pose specific challenges to dominant assumptions of masculinity such as bodily strength, control of the body and of emotions, independence and resistance to pain, and for this reason it has been considered as particularly appropriate for exploring the complex intertwining of chronic illness and gender. More specifically, the analysis focused on three areas: namely, the impact of chronic illness in the everyday life; the multiple ways of ?doing? masculinity in the context of the ?doing? of autoimmune diabetes; and, lastly, the impact of diabetes and of the medicalization of male sexual health on sexuality and intimacy practices. Overall, the empirical material allowed for great insight into men?s experiences of illness and depicted a complex picture, very different from the monolithic description offered by the majority of studies previously conducted on this issue.
EVALUATING THE EFFICACY OF CURCUMIN IN COUNTERACTING TESTICULAR DAMAGE INDUCED BY KETOCONAZOLE
Creators: name: Onoja, P.O
name: Akunna, G.G
name: Saalu, L.C
Publisher: name: AYDEN JOURNAL
Year: 2024
Subjects: Curcumin, Ketoconazole, Testicular Damage, Male Infertility, Antioxidant, Reproductive Health, Protective Effects.

description: The delicate balance of hormonal, biochemical, and cellular processes governing testicular health is crucial for male fertility and overall well-being. However, pharmaceutical agents like ketoconazole can disrupt this equilibrium, leading to testicular damage and reproductive dysfunction. Curcumin, a bioactive compound known for its antioxidant and anti-inflammatory properties, has shown promise in mitigating drug-induced damage in various organs. Yet, its specific role in safeguarding testicular health against pharmaceutical-induced damage remains relatively unexplored. This study aimed to evaluate the efficacy of curcumin in mitigating ketoconazole-induced testicular damage using animal models. Fifty-four (54) adult male Wistar rats were divided into nine groups and treated with varying doses of ketoconazole and curcumin for twenty-eight (28) days accordingly. Results revealed that ketoconazole administration adversely affected testicular morphology, hormonal profiles, oxidative stress markers, sperm parameters, and histological characteristics. However, curcumin, particularly when administered in combination with ketoconazole, demonstrated protective effects against these adverse outcomes. Notably, curcumin administration before ketoconazole treatment showed promising results in preserving sperm parameters, even surpassing control levels in certain instances. These findings underscore the potential therapeutic utility of curcumin in combating drug-induced testicular damage and highlight avenues for further mechanistic exploration. Understanding the molecular pathways involved in curcumin's protective effects may offer novel strategies for managing male infertility and preserving reproductive function in men undergoing pharmacological treatments
Molecular diffusion between walls with adsorption and desorption
Creators: name: Levesque, Maximilien
name: Bénichou, Olivier
name: Rotenberg, Benjamin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The time dependency of the diffusion coefficient of particles in porous media is an efficient probe of their geometry. The analysis of this quantity, measured e.g. by nuclear magnetic resonance (PGSE-NMR), can provide rich information pertaining to porosity, pore size distribution, permeability and surface-to-volume ratio of porous materials. Nevertheless, in numerous if not all practical situations, transport is confined by walls where adsorption and desorption processes may occur. In this article, we derive explicitly the expression of the time-dependent diffusion coefficient between two confining walls in the presence of adsorption and desorption. We show that they strongly modify the time-dependency of the diffusion coefficient, even in this simple geometry. We finally propose several applications, from sorption rates measurements to the use as a reference for numerical implementations for more complex geometries.
description: 4 pages, 2 figures, 1 supplementary material of 3 pages
title: Вихревые трубы в силовых установках транспортной энергетики
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2017

description: В монографии рассматриваются вопросы использования вихревых труб в силовых установках транспортной энергетики, что является совершенно новым и оригинальным подходом к решению целого ряда важных задач, связанных с совершенствованием этих установок. Рассмотрена эффективность использования вихревых труб при решении вопросов снижения токсичности отработавших газов двигателей внутреннего сгорания, их наддува и ряда других аспектов функционирования двигателей внутреннего сгорания.
WATs Up? Exploring the Impact of Wearable Activity Trackers on Physical Activity and Wellbeing: A Systematic Research Review
Creators: name: Lasikiewicz, Nic
name: Scudds, Annie
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: activity trackers
subject: physical activity
subject: wellbeing

description: The aim of this review is to provide a systematic review and quality assessment of studies that have evaluated the impact of a wrist-based wearable activity tracker (WAT) on physical activity engagement and psychological wellbeing in healthy adults. The psychological outcomes most frequently assessed were identified and discussed in relation to increases in physical activity. Finally, the potential mediating effects of motivation to engage in exercise were reviewed in the resulting papers.
title: Гражданско-правовая защита авторских прав
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2017

description: В монографии рассматриваются проблемы применения форм и способов защиты авторских прав. Особое внимание уделено защите авторских прав организациями, управляющими правами автора на коллективной основе и самозащите авторских прав. В работе проведен анализ проблем взыскания компенсации за нарушение авторских прав в судебном порядке. Исследован вопрос защиты авторских прав в сети Интернет, в том числе проблемы привлечения к гражданско-правовой ответственности информационного посредника. На основе анализа применения института гражданско-правовой защиты авторских прав и сложившейся судебной практики сформулированы выводы и предложения по совершенствованию законодательства. Книга адресована научным сотрудникам, преподавателям, аспирантам, магистрантам и студентам юридических вузов, а также для широкого круга читателей.
Effect of Dresselhaus spin-orbit coupling on spin dephasing in asymmetric and macroscopically symmetric (110)-grown quantum wells
Creators: name: Poshakinskiy, A. V.
name: Tarasenko, S. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We develop the microscopic theory of electron spin dephasing in (110)-grown quantum wells where the electron scattering time is comparable to or exceeds the period of spin precession in the effective magnetic field caused by spin-orbit coupling. Structures with homogeneous and fluctuating Rashba field, which triggers the dephasing of electron spins aligned along the growth direction, are analyzed. We show that the Dresselhaus field, which is always present in zinc-blende-type quantum wells, suppresses the spin dephasing enabling very long spin lifetime of conduction electrons. The dependence of the spin lifetime on the electron mobility is found to be nonmonotonic reaching the minimum in structures where the scattering time is comparable to the period of spin precession in the effective magnetic field.
description: 7 pages, 5 figures
Two-dimensional arrays of superconducting and soft magnetic strips as dc magnetic metamaterials
Creators: name: Mawatari, Yasunori
Publisher: name: arXiv
Year: 2013
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We have theoretically investigated the magnetic response of two-dimensional (2D) arrays of superconducting and soft magnetic strips, which are regarded as models of dc magnetic metamaterials. The anisotropy of the macroscopic permeabilities depends on whether the applied magnetic field is parallel to the wide surface of the strips ($μ_{\parallel}$) or perpendicular ($μ_{\perp}$). For the 2D arrays of superconducting strips, $00$.
description: 21 pages, 14 figures, accepted for publication in Supercond. Sci. Technol
title: Информатика. Информационные технологии
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2017

description: Пособие ориентировано на изучение информатики, информационных технологий. В нем представлены авторские разработки лабораторных работ, включающие краткие теоретические сведения, практический материал, контрольные вопросы и индивидуальные задачи для выполнения. Учебное пособие предназначено для студентов направлений 09.03.02 «Информационные системы и технологии», 38.03.05 «Бизнес-информатика», 08.03.01 «Строительство», 13.03.02 «Электроэнергетика и электротехника», 23.03.01 «Технология транспортных процессов», 38.03.02 «Менеджмент», 38.03.04 «Государственное и муниципальное управление», 38.05.01 «Экономическая безопасность», 38.05.02 «Таможенное дело» при изучении дисциплин, связанных с обработкой информации средствами информационных технологий
Improving Monte Carlo simulations by Dirichlet forms
Creators: name: Bouleau, Nicolas
Publisher: name: arXiv
Year: 2013
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Equipping the probability space with a local Dirichlet form with square field operator Γand generator A allows to improve Monte Carlo simulations of expectations and densities as soon as we are able to simulate a random variable X together with Γ[X] and A[X]. We give examples on the Wiener space, on the Poisson space and on the Monte Carlo space. When X is real-valued we give an explicit formula yielding the density at the speed of the law of large numbers.
Andreev magneto-interferometry in topological hybrid junctions
Creators: name: Carmier, Pierre
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We investigate the influence of the superconducting (S) proximity effect in the quantum Hall (QH) regime by computing the charge conductance flowing through a graphene-based QH/S/QH junction. This situation offers the exciting possibility of studying the fate of topological edge states when they experience tunneling processes through the superconductor. We predict the appearance of conductance peaks at integer values of the Landau level filling factor, as a consequence of the quantum interferences taking place at the junction, and provide a semiclassical analysis allowing for a natural interpretation of these interferences in terms of electron and hole trajectories propagating along the QH/S interfaces. Our results suggest that non-trivial junctions between topologically distinct phases could offer a highly tunable means of partitioning the flow of edge states.
description: 5 pages, 3 figures; changed title and added discussion on topological junctions
title: История государства и права зарубежных стран
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2017

description: Практикум предназначен для обучающихся по направлению 40.03.01 «Юриспруденция» является единым для всех форм обучения, составлен в соответствии с требованиями ФГОС ВО с учетом рекомендаций и ОП ВО по направлению (специальности) и профилю подготовки, рабочей программы дисциплины «История государства и права зарубежных стран». Практические занятия по курсу проводятся в интерактивной форме и базируются на применении проблемного подхода к анализу юридического источника, контекстуализации правовых концепций и норм в рамках глобальных и региональных трендов исторического развития, формулировки определений к юридическим терминам, поиска и верификации найденной информации, использования методик устной и мультимедийной презентации полученных выводов, решения юридических казусов на основе изучаемых источников, анализа научных текстов, метода научной дискуссии.
Classical-Quantum Correspondence and Functional Relations for Painleve Equations
Creators: name: Zabrodin, A.
name: Zotov, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: In the light of the Quantum Painleve-Calogero Correspondence established in our previous papers [1,2], we investigate the inverse problem. We imply that this type of the correspondence (Classical-Quantum Correspondence) holds true and find out what kind of potentials arise from the compatibility conditions of the related linear problems. The latter conditions are written as functional equations for the potentials depending on a choice of a single function - the left-upper element of the Lax connection. The conditions of the Correspondence impose restrictions on this function. In particular, it satisfies the heat equation. It is shown that all natural choices of this function (rational, hyperbolic and elliptic) reproduce exactly the Painleve list of equations. In this sense the Classical-Quantum Correspondence can be regarded as an alternative definition of the Painleve equations.
description: 38 pages, minor corrections
INTEGRATION FACTORS IN STRENGTHENING PEACE AND STABILITY IN THE DEVELOPMENT OF THE NEW UZBEKISTAN
Creators: name: Alijonov, Baxtiyor
Publisher: name: Zenodo
Year: 2023

description: In this article, the spiritual, moral and cultural development of the society, the development of the social development the new Uzbekistan and the processes of consolidation of peace and stability, of course, have a unique partnership with the neighboring countries. In this regard, turning Central Asia into a region of peace, sustainable development and good neighborliness is defined as a priority direction of foreign policy. For example, it was highlighted that the formation of security, stability, harmonious neighborhood environment in the vicinity of Uzbekistan was strengthened as a priority task in the near future.
KEEPING UP APPEARANCES: COLORS AND THEIR LOOKS
Creators: name: PUCKO, KRISTINA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: This thesis concerns the utility of color appearances given the tricky relationship between our visual system, the phenomenology of color experiences and the urge for the ontological status of colors. On the one hand, the color constancy phenomena is generally thought to motivate color realism and on the other hand, so-called impossible color phenomena is generally thought to motivate the irrealist accounts. I show that none of these two gives us grounds to adopt either of the ontological positions. Instead, I argue that color appearances do not give us direct information about the alleged externality or internality of colors. Following this line of thought, I propose to stay agnostic about the ontological status of colors derived from their appearances. Moreover, I argue that the primary function of color vision is to discriminate among rather than detect properties. I conclude by showing that color vision understood as non-primal discriminatory capacity does nevertheless, has important roles in visual perception. Among others, its perquisites are effortlessness and usefulnessness.
On the spectral theory of Gesztesy-Šeba realizations of 1-D Dirac operators with point interactions on a discrete set
Creators: name: Carlone, Raffaele
name: Malamud, Mark
name: Posilicano, Andrea
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 34L05 (Primary), 34L40, 47E05, 47B25, 47B36, 81Q10 (Secondary)

description: We investigate spectral properties of Gesztesy-Šeba realizations D_{X,α} and D_{X,β} of the 1-D Dirac differential expression D with point interactions on a discrete set $X=\{x_n\}_{n=1}^\infty\subset \mathbb{R}.$ Here $α:= \{α_{n}\}_{n=1}^\infty$ and β:=\{β_{n}\}_{n=1}^\infty \subset\mathbb{R}. The Gesztesy-Šeba realizations $D_{X,α}$ and $D_{X,β}$ are the relativistic counterparts of the corresponding Schrödinger operators $H_{X,α}$ and $H_{X,β}$ with $δ$- and $δ'$-interactions, respectively. We define the minimal operator D_X as the direct sum of the minimal Dirac operators on the intervals $(x_{n-1}, x_n)$. Then using the regularization procedure for direct sum of boundary triplets we construct an appropriate boundary triplet for the maximal operator $D_X^*$ in the case $d_*(X):=\inf\{|x_i-x_j| \,, i\not=j\} = 0$. It turns out that the boundary operators $B_{X,α}$ and $B_{X,β}$ parameterizing the realizations D_{X,α} and D_{X,β} are Jacobi matrices. These matrices substantially differ from the ones appearing in spectral theory of Schrödinger operators with point interactions. We show that certain spectral properties of the operators $D_{X,α}$ and $D_{X,β}$ correlate with the corresponding spectral properties of the Jacobi matrices $B_{X,α}$ and $B_{X,β}$, respectively. Using this connection we investigate spectral properties (self-adjointness, discreteness, absolutely continuous and singular spectra) of Gesztesy--{\vS}eba realizations. Moreover, we investigate the non-relativistic limit as the velocity of light $c\to\infty$. Most of our results are new even in the case $d_*(X)> 0.$
description: accepted for publication in Journal of Differential Equations
EOSC Security Operational Baseline 2022
Creators: name: Groep, David Leo
name: Kelsey, David
name: Crooks, David
name: Cornwall, Linda
name: Gabriel, Sven
name: Grenier, Baptiste
name: Kaila, Urpo
name: Koskinen, Pinja
name: Kouřil, Daniel
name: Moens, Alf
name: Neilson, Ian
name: Niederberger, Ralph
name: Viljoen, Matthew
name: Wartel, Romain
Publisher: name: Zenodo
Year: 2022
Subjects: EOSC
ISM
Security

description: This Security Baseline supports these goals by defining minimum expectations and requirements of the behaviour of those offering services to users and communities connected to the EOSC, and of those providing access to services or assembling service components through the EOSC. It aims to establish a sufficient level of trust between all Participants in the Infrastructure to enable reliable and secure Infrastructure operation.
IDENTIFICATION OF EPIGENETIC INHIBITORS OF PHYSIOLOGICAL CELLULAR PLASTICITY AS NOVEL TUMOR SUPPRESSOR
Creators: name: XIERAILI, AOBULI
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: Cellular plasticity, the inter-conversion of cells between differentiated cells and stem cells (SCs), can lead to tissue regeneration and restoration of homeostasis after injury. Conversely, inappropriate induction of cellular plasticity could be involved in tumor initiation and progression, through de-novo generation of cancer stem cells (CSCs) by de-differentiation of normal or non-tumorigenic bulk tumor cells. This intrinsically dangerous potential must be tightly controlled by genetic and epigenetic mechanisms, to prevent unscheduled de-differentiation. However, their systematic identification by large-scale screenings is just beginning to be exploited. In order to identify physiological inhibitors of cell plasticity, that could play a function as tumor suppressors, we performed short-hairpin RNA (shRNA) screens. In the screens, we used pooled lentiviral shRNA libraries targeting 234 epigenetic regulators to identify shRNAs endowing mouse mammary progenitors with the SC-specific ability to regenerate mammary gland tissue upon in vivo orthotopic transplantation. Sequencing of genomic DNA extracted from the regenerated mammary glands led to the identification of 38 hits/genes. We individually validated 7 hits by in vivo regeneration assays, showing that their down-regulation leads to conversion of mammary progenitors into stem cells able to regenerate mammary glands. We performed also in vitro mammosphere and phenotypic cell conversion assays to examine the hits? function in self-renewal and cell plasticity, respectively. Next, among the validated hits, we showed that the inhibition of Cbx5 and Kmt2d induced efficient reprogramming of mammary progenitors. Therefore, we focused to investigate their mechanistic function in reprogramming at the transcriptome level, by RNA sequencing. We identified a specific enrichment for pro-inflammatory signalling pathways as an early transcriptional reprogramming response (ETRR), followed by up-regulation of Myc target genes. Finally, in order to set the basis for further characterization of reprogramming mechanisms induced by the validated shRNAs, we established an organoid assay using MycER, our positive control for mammary progenitors reprogramming, showing that MycER over-expression bestows mouse luminal cells with enhanced self-renewal ability and differentiation capacity. Moreover, we performed a single cell transcriptome analysis in mouse primary mammospheres that revealed considerable heterogeneity as 20 clusters identified and led to the identification of Cd36 (glycoprotein, collagen type I receptor) as a putative mammary SC-specific surface marker. We expect that further analyses of these data, together with single cell transcriptomic analysis of mammospheres interfered for the validated hits, will shed light on the mechanisms involved in physiological cell plasticity.
DEKKERA BRUXELLENSIS: STUDIES ON CARBON AND NITROGEN SOURCES METABOLISM AND ITS RESPONSE TO ACETIC ACID STRESS.
Creators: name: MOKTADUZZAMAN, MD
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The lineages of Dekkera bruxellensis and Saccharomyces cerevisiae separated approximately 200 million years ago, but they share several industrially relevant traits, such as the ability to produce ethanol under aerobic conditions (Crabtree effect), high tolerance towards ethanol and acid, and ability to grow without oxygen. Beside a huge adaptability, D. bruxellensis exhibits a broader spectrum of consumable carbon and nitrogen sources in comparison to S. cerevisiae. This yeast is famous as a spoilage yeast in food and beverage industries and contaminates ethanol production process. Despite its economic importance and physiological interest, D. bruxellensis has not been well studied yet in detail. To characterize its carbon metabolism and regulation, we investigated how galactose is used as carbon source by this yeast. Here we show that in D. bruxellensis under aerobic conditions and on ammonium-based media galactose is a not-fermentable carbon source, in contrast to S. cerevisiae which can ferment also this sugar. The expression of genes involved in different metabolic pathways was also analysed. We report that genes involved in galactose utilization, respiratory metabolism, TCA cycle, glyoxylate cycle and gluconeogenesis are repressed in glucose-based media. These results indicate that in D. bruxellensis glucose repression operates similarly to what occurs in S. cerevisiae. In contrast to Saccharomyces cerevisiae, D. bruxellensis can use nitrate as sole nitrogen source. Our experiments showed that in D. bruxellensis, utilization of nitrate determines a different pattern of fermentation products. Acetic acid, instead of ethanol, became in fact the main product of glucose metabolism under aerobic conditions. We have also demonstrated that under anaerobic conditions, nitrate assimilation abolishes the ??Custers effect??, in this way improving its fermentative metabolism. Acetic acid, due to its toxic effects, is used in food industry as a preservative against microbial spoilage. We investigated how this yeast responds when exposed to acetic acid. A detailed analysis of acetic acid metabolism was performed on three strains which exhibited a different resistance. Our studies show that D. bruxellensis behaves, from a metabolic point of view, more similarly to S. cerevisiae, being unable to metabolize acetic acid in presence of glucose. The presence of acetic acid affected the growth, causing a reduction of growth rate, glucose consumption rate, ethanol production rate as well as biomass and ethanol yield. Interestingly, the cells continued to produce acetic acid.
Magnetic tornadoes and chromospheric swirls -- Definition and classification
Creators: name: Wedemeyer, Sven
name: Scullion, Eamon
name: Steiner, Oskar
name: Rodriguez, Jaime de la Cruz
name: van der Voort, Luc Rouppe
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Chromospheric swirls are the observational signatures of rotating magnetic field structures in the solar atmosphere, also known as magnetic tornadoes. Swirls appear as dark rotating features in the core of the spectral line of singly ionized calcium at a wavelength of 854.2 nm. This signature can be very subtle and difficult to detect given the dynamic changes in the solar chromosphere. Important steps towards a systematic and objective detection method are the compilation and characterization of a statistically significant sample of observed and simulated chromospheric swirls. Here, we provide a more exact definition of the chromospheric swirl phenomenon and also present a first morphological classification of swirls with three types: (I) Ring, (II) Split, (III) Spiral. We also discuss the nature of the magnetic field structures connected to tornadoes and the influence of limited spatial resolution on the appearance of their photospheric footpoints.
description: 8 pages, 4 figures, proceedings article for the conference "Eclipse on the Coral Sea: Cycle 24 Ascending" GONG 2012/LWS/SDO-5/SOHO 27, which has been held in Palm Cove, Australia, in 2012. Accepted version
title: Основы таможенного дела
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2018

description: Учебное пособие предназначено для изучения пропедевтического курса «Основы таможенного дела» и содержит краткие теоретические материалы о таможенной сфере, об ориентирах развития и функциональной деятельности таможенной службы РФ. Данное пособие направлено на приобретение студентами представления о таможенном деле и формированию у них общекультурных и профессиональных компетенций. Содержание учебного пособия соответствует требованиям Федерального государственного образовательного стандарта высшего образования четвертого поколения по специальности 38.05.02 «Таможенное дело». Учебное пособие предназначено для работы студентов, обучающихся по экономическим направлениям и специальностям, освоения курса декларантами, специалистами по таможенным операциям, а также слушателям различных курсов повышения квалификации в области внешнеэкономической деятельности и предпринимателям.
title: Поведение потребителей
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2017

description: Учебное пособие ставит своей целью познакомить обучающихся с основными понятиями, составляющими область исследования потребительского поведения и вооружить их базовыми знаниями об основных механизмах его формирования и регуляции. В нем представлен краткий ретроспективный анализ теоретических исследований и прикладных проблем в области изучения поведения потребителей; подробно рассмотрено влияние на его особенности различных групп социальных и психологических факторов. Учебное пособие предназначено для обучающихся по направлению 38.03.02 «Менеджмент», но также может быть интересно для обучающихся и на других экономических специальностях и направлениях.
BLOCKCHAIN & DATA JUSTICE. THE POLITICAL CULTURE OF TECHNOLOGY
Creators: name: SEMENZIN, SILVIA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Blockchain is a distributed ledger technology arising from the world of Bitcoin and cryptocurrencies, which has been advocated as a disruptive and revolutionary innovation. Because of the peculiarity of its architectural technicalities, in fact, blockchain technology has seen a growth of its social applications in recent years and has gained the attention of a large variety of actors, interested in its potentiality for entering the social domain and enabling the creation of decentralized, horizontal and peer-to-peer networks. This thesis aims at studying the visions of the world surrounding the implementation of blockchain technology, by analyzing narratives and discourses emerging among those who create and use it. Based on a critical understanding of algorithms and technology as non-neutral and as subject to bias and pitfalls, this work focuses on the sociological and political significance of imagining a technology for the social and public good, posing a particular attention to developers and digital entrepreneurs? understanding of sociality. Drawing on a one-year multi-sited fieldwork in Milan, London, Tallinn and the online sphere, this work combines a theoretical analysis with ethnographical insights that arise from participant observation and a number of interviews with individuals from the blockchain scene. By relying on a qualitative study that aims at researching the values and aspirations that are encoded in technology, I argue that blockchain social imaginary is embedded in neoliberal, technocratic visions of the world and that blockchainers? understanding of society and social relations becomes tokenized and subject to mathematical simplifications. My argument develops in three phases: firstly, I show how blockchain works as a floating signifier and thus could be interpreted as a populist buzzword; secondly, I argue that blockchain is surrounded by regimes of truth regarding its disruptive potential that overlooks social dynamics and logics; thirdly, I show that blockchainers? understanding of social good is based on metrics and competition, thereby reinforcing a number of neoliberal myths associated with the Californian Ideology. By showing the importance of integrating more sociological perspectives to the study of digital technology?s potential, this work exits the financial and informatics domain, merging previous studies on blockchain with a human-rights based approach that ground its roots on social justice theory.
title: Страхование
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2017

description: Учебное пособие ставит своей целью познакомить обучающихся с основными понятиями, составляющими область исследования страхования. Учебное пособие предназначено для обучающихся по специальностям 38.05.01 «Экономическая безопасность» и 38.05.02 «Таможенное дело».
Conductance scaling in Kondo correlated quantum dots: role of level asymmetry and charging energy
Creators: name: Merker, L.
name: Kirchner, S.
name: Muñoz, E.
name: Costi, T. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The low temperature electrical conductance through correlated quantum dots provides a sensitive probe of the physics (e.g., of Fermi-liquid vs non-Fermi-liquid behavior) of such systems. Here, we investigate the role of level asymmetry (gate voltage) and local Coulomb repulsion (charging energy) on the low temperature and low field scaling properties of the linear conductance of a quantum dot described by the single level Anderson impurity model. We use the numerical renormalization group to quantify the regime of gate voltages and charging energies where universal Kondo scaling may be observed and also quantify the deviations from this universal behavior with increasing gate voltage away from the Kondo regime and with decreasing charging energy. We also compare our results with those from a recently developed method for linear and non-linear transport, which is based on renormalized perturbation theory using dual fermions, finding excellent agreement at particle-hole symmetry and for all charging energies and reasonable agreement at small finite level asymmetry. Our results could be a useful guide for detailed experiments on conductance scaling in semiconductor and molecular quantum dots exhibiting the Kondo effect.
description: 15 pages, 8 figures
title: Тепловые накопители энергии в силовых установках и теплогенерирующих установках транспортной энергетики
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский институт управления и экономики
Year: 2018

description: В монографии приведены результаты исследований, связанных с использованием тепловых накопителей энергии в различных системах поршневых двигателей внутреннего сгорания, являющихся основным типом силовых установок в транспортной энергетике. В частности, рассмотрены вопросы использования тепловых накопителей на впуске двигателей с наддувом, обеспечивающего повышение мощностных и экономических показателей; на выпуске – для повышения экологической безопасности и обеспечения утилизации тепловых потерь с отработавшими газами, а также положительный эффект от использования тепловых накопителей энергии для обеспечения пуска поршневых двигателей внутреннего сгорания транспортных машин в условиях низких температур окружающей среды. Книга предназначена для специалистов в области транспортной энергетики, а также для преподавателей, аспирантов и студентов соответствующих специальностей.
title: Games with Comparative Utility Functions
Creators: name: Meister, Helmut
Publisher: name: MyCoRe Community
Year: 2020
Subjects: subject: Game Theory
subject: Non-cooperative games
subject: Nash Equilibrium Strategies
subject: Pure Strategy Equilibrium
subject: Preference Scheme
subject: Comparative Expected Utility
subject: 510

description: The central objects of investigation of this paper are games with comparative utility functions. This concept can be considered as a relativistic approach to expected utility theory. The approach covers also the classical idea of utility functions. In some recent research papers the philosophic justification for games of this type has been discussed in more detail. The notion of a Nash Equilibrium also applies to the context of noncooperative games with comparative utility functions for the players. We will show that equilibria in the sense of Nash can be characterized by the solutions of complementarity problems in a very similar way as for classical non-cooperative games. Moreover, the question of existence of pure strategy Nash Equilibrium will be discussed. If the utility functions are realizations of random variables, the frequency of pure strategy equilibrium appearance for games with a large number of options follows the (...)-rule. This behavior has already been derived for classical noncooperative games, but the stochastic properties are somewhat different for comparative games.
Status of detector development for the European XFEL
Creators: name: Sztuk-Dambietz, Jolanta
name: Hauf, Steffen
name: Koch, Andreas
name: Kuster, Markus
name: Turcato, Monica
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The European X-ray Free Electron Laser (XFEL.EU) will provide as-yet-unrivaled peak brilliance and ultra-short pulses of spatially coherent X-rays with a pulse length of less than 100 fs in the energy range between 0.25 and 25 keV. The high radiation intensity and ultra-short pulse duration will open a window for novel scientific techniques and will allow to explore new phenomena in biology, chemistry, material science, as well as matter at high energy density, atomic, ion and molecular physics. The variety of scientific applications and especially the unique XFEL.EU time structure require adequate instrumentation to be developed in order to exploit the full potential of the light source. To make optimal use of the unprecedented capabilities of the European XFEL and master these vast technological challenges, the European XFEL GmbH has started a detector R&D program. The technology concepts of the detector system presently under development are complementary in their performance and will cover the requirements of a large fraction of the scientific applications envisaged for the XFEL.EU facility. The actual status of the detector development projects which includes ultra-fast 2D imaging detectors, low repetition rate 2D detectors as well as strip detectors for e.g. spectroscopy applications and the infrastructure for the detectors' calibration and tests will be presented. Furthermore, an overview of the forthcoming implementation phase of the European XFEL in terms of detector R&D will be given.
description: Prepared for the Proccedings of SPIE Optics + Optoelectronics Conference, Prague, Czech Republic, 15th - 18th April 2013