cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CLIL and CALL for a teacher’s expertise: an international training experience
Creators: name: Cinganotto, Letizia
name: Cuccurullo, Daniela
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2016

description: The paper deals with the link between Content and Language Integrated Learning (CLIL) and Computer Assisted Language Learning (CALL), that is the use of ICT to enhance language teaching-learning and the teaching of subject content in a foreign language. Starting from this background, the paper describes an online training initiative promoted by the authors within an international community of peers, made up of teachers, trainers and educators from all over the world, named “Techno-CLIL for EVO 2016”. The initiative was aimed at supporting and guiding participants to discover and experiment digital tools for CLIL lessons, offering the opportunity to share ideas, materials, good practices in an international perspective. Particular attention is devoted to the personal and professional enrichment and growth this training pathway may have helped the 5.000 participants to achieve. CLIL e CALL nell’expertise del docente: un’esperienza di formazione internazionale Il contributo focalizza l’attenzione sulla correlazione tra Content and Language Integrated Learning (CLIL) e Computer Assisted Language Learning (CALL), cioè l’uso delle tecnologie per una maggiore efficacia dell’insegnamento-apprendimento delle lingue o di contenuti disciplinari veicolati in lingua straniera. Partendo da questo background, il contributo descrive una iniziativa di formazione online in lingua inglese promossa dalle autrici all’interno di un contesto internazionale, costituito da una comunità di pratica di docenti, formatori, educatori di tutto il mondo, denominata “Techno-CLIL for EVO 2016”. L’iniziativa mirava a sensibilizzare e guidare i partecipanti nella scoperta e sperimentazione della didattica CLIL in modalità digitale, offrendo l’opportunità di un confronto ed uno scambio di idee, materiali, buone pratiche in una prospettiva internazionale. Particolarmente significative le ricadute che questo percorso ha comportato per i circa 5.000 partecipanti in termini di expertise, competenze professionali e arricchimento personale.
description: Form@re - Open Journal per la formazione in rete, Vol. 16 No. 2 (2016): The teachers' expertise
title: Notaufnahmeübergreifende Datenintegration und Datenharmonisierung digitaler Daten für die Versorgungsforschung im Projekt INDEED
Creators: name: Greiner, Felix
name: Fischer-Rosinský, Antje
name: Slagman, Anna
name: Keil, Thomas
name: Erdmann, Bernadett
name: Walcher, Felix
name: Möckel, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Bei steigenden Fallzahlen und im Kontext aktueller Entwicklungen in Gesundheitspolitik und Selbstverwaltung besteht derzeit ein hoher Bedarf an verlässlichen Daten zur Nutzung von Notaufnahmen. Im Projekt INDEED „Inanspruchnahme und sektorenübergreifende[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Multiple q-Kravchuk polynomials
Creators: name: Arvesú, J.
name: Ramírez-Aberasturis, A. M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 42C05 (Primary) 33C47, 33E99 (Secondary)

description: We study a family of type II multiple orthogonal polynomials. We consider orthogonality conditions with respect to a vector measure, in which each component is a q-analogue of the binomial distribution. The lowering and raising operators as well as the Rodrigues formula for these polynomials are obtained. The difference equation of order r+1 is studied. The connection via limit relation between four types of Kravchuk polynomials is discussed.
description: This is a 2020 preprint (before acceptance) of the 2021 article published in Integral Transformations and Special Functions
Synthesizing Exoplanet Demographics: A Single Population of Long-Period Planetary Companions to M Dwarfs Consistent with Microlensing, Radial Velocity, and Direct Imaging Surveys
Creators: name: Clanton, Christian
name: Gaudi, B. Scott
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the first study to synthesize results from five different exoplanet surveys using three independent detection methods: microlensing, radial velocity, and direct imaging. The constraints derived herein represent the most comprehensive picture of the demographics of large-separation (>~ 2 AU) planets orbiting the most common stars in our Galaxy that has been constructed to date. We assume a simple, joint power-law planet distribution function of the form d^2N_{pl}/[dlog(m_p)dlog(a)] = A(m_p/M_{Sat})^{alpha}(a/2.5 AU)^{beta} with an outer cutoff radius of the separation distribution function of a_{out}. Generating populations of planets from these models and mapping them into the relevant observables for each survey, we use actual or estimated detection sensitivities to determine the expected observations for each survey. Comparing with the reported results, we derive constraints on the parameters {alpha, beta, A, a_{out}} that describe a single population of planets that is simultaneously consistent with the results of microlensing, RV, and direct imaging surveys. We find median and 68% confindence intervals of alpha = -0.86^{+0.21}_{-0.19} (-0.85^{+0.21}_{-0.19}), beta = 1.1^{+1.9}_{-1.4} (1.1^{+1.9}_{-1.3}), A = 0.21^{+0.20}_{-0.15} dex^{-2} (0.21^{+0.20}_{-0.15} dex^{-2}), and a_{out} = 10^{+26}_{-4.7} AU (12^{+50}_{-6.2} AU) assuming "hot-start" ("cold-start") planet evolutionary models. These values are consistent with all current knowledge of planets on orbits beyond ~2 AU around M dwarfs.
description: 33 pages, 30 figures. Submitted to ApJ. Comments welcome
Erratum to: Measurement of differential cross sections and W+/W− cross-section ratios for W boson production in association with jets at s $$ \sqrt{s} $$ = 8 TeV with the ATLAS detector
Creators: name: More Than 100 Authors
Publisher: name: My University
Year: 2020

description: For a complete list of authors, please look at article.
description: Two additions impacting tables 3 and 4 in ref. [1] are presented in the following. No significant impact is found for other results or figures in ref. [1].
Evanescent field trapping and propulsion of Janus particles along optical nanofibers
Creators: name: Tkachenko, Georgiy
name: Truong, Viet Giang
name: Esporlas, Cindy Liza
name: Sanskriti, Isha
name: Nic Chormaic, Síle
Publisher: name: figshare
Year: 2023
Subjects: Other physical sciences not elsewhere classified

description: Source data, videos, and codes for our paper "Evanescent field trapping and propulsion of Janus particles along optical nanofibers".
 - 'Source videos.zip' = zipped collection of source videos of light-induced propulsion of 3um silica microspheres either uncoated or half-coated with a gold layer of thickness d=10nm or d=20nm.
 - MATLAB codes process the videos and plot the experimental results shown in Figs.4-6 of the paper. The codes must be placed in the same folder as 'Fig4ab', 'Fig4cde', 'Fig5de', and 'Fig6' folders which contain the corresponding collections of video files and short text notes.
 - 'Source Data.zip' = zipped collection of the resultant data in Excel spreadsheets.
 -'COMSOL_Model_Janus_particles.mph' = COMSOL model for the simulations.
 - 'Suppl_video1.mp4', 'Suppl_video2.mp4', 'Suppl_video3.mp4' = supplementary video files cited in the paper.
Metamorphosis of the Cosmological Constant and 5D Origin of the Fiducial Metric
Creators: name: Gabadadze, Gregory
name: Yu, Siqing
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In a recently proposed theory, the cosmological constant (CC) does not curve spacetime in our universe, but instead gets absorbed into another universe endowed with its own dynamical metric, nonlocally coupled to ours. Thus, one achieves a long standing goal of removing entirely any cosmological constant from our universe. Dark energy then cannot be due to a cosmological constant, but must be obtained via other mechanisms. Here we focus on the scenario in which dark energy is due to massive gravity and its extensions. We show how the metric of the other universe, that absorbs our CC, also gives rise to the fiducial metric known to be necessary for the diffeomorphism invariant formulation of massive gravity. This is achieved in a framework where the other universe is described by 5D AdS gravity, while our universe lives on its boundary and is endowed with dynamical massive gravity. A non-dynamical pullback of the bulk AdS metric acts as the fiducial metric for massive gravity on the boundary. This framework also removes a difficulty caused by the quantum strongly coupled behavior of massive gravity at the Lambda3 scale: in the present approach, the massive gravity action does not receive any loop-induced counterterms, despite being strongly coupled.
description: 23 latex pages; v2: comments on quantum loops expanded and earlier works cited; old and newer papers on bigravity cited; comments added. v3: further minor comments added, to appear in PRD
Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver–Russell syndrome phenotypes
Creators: name: Berger, Shelley L.
name: Riccio, Andrea
name: Freschi, Andrea
name: Bartolomei, Marisa S.
name: Hur, Stella K.
name: Weller, Angela H.
name: Cerrato, Flavia
name: Luense, Lacey J.
name: Thorvaldsen, Joanne L.
name: Ideraabdullah, Folami
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Genomic imprinting is essential for mammalian development. Curiously, elements that regulate genomic imprinting, the imprinting control regions (ICRs), often diverge across species. To understand whether the diverged ICR sequence plays a species-specific role at the H19/insulin-like growth factor 2 (Igf2) imprinted locus, we generated a mouse in which the human ICR (hIC1) sequence replaced the endogenous mouse ICR. We show that the imprinting mechanism has partially diverged between mouse and human, depending on the parental origin of the hIC1 in mouse. We also suggest that our mouse model is optimal for studying the imprinting disorders Beckwith–Wiedemann syndrome when hIC1 is maternally transmitted, and Silver–Russell syndrome when hIC1 is paternally transmitted.
An experimental approach for science laboratories in the contest of science of primary education degree course
Creators: name: Bozzo, Giacomo
name: De Pietro, Orlando
name: Valenti, Antonella
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2016

description: International literature in science education has shown the importance of introducing scientific studies in primary school, in order to give pupils competences and skills necessary for their life. Consequently, prospective primary teachers need to improve their scientific knowledge and to plan new experimental activities for primary school students. In this context, we have planned an educational learning path for prospective primary teachers, focused on specific conceptual knows of kinematics. The proposed activities are based on an empirical approach, avoiding in the first step any formal introduction of the observed phenomena, which could be difficult to understand, especially for students of science of primary education degree course. In this context, the educational technologies have given a fundamental support, since they have offered to prospective teachers the possibility to focus their attention only on the involved physics concepts and principles. Un approccio sperimentale per i laboratori scientifici nei corsi di laurea in Scienze della Formazione Primaria Studi recenti hanno evidenziato la necessità di introdurre le discipline scientifiche sin dalla scuola primaria, per consentire alle future generazioni di vivere in modo critico e consapevole nel mondo reale. I futuri insegnanti hanno, quindi, la necessità di approfondire le loro conoscenze in ambito scientifico e di progettare valide attività laboratoriali per gli alunni di scuola primaria. In questo contesto si inserisce la nostra azione formativa rivolta agli studenti di Scienze della Formazione Primaria (SFP), mirata ad affrontare alcune difficoltà nell’apprendimento della Fisica, ben note in letteratura. L’attività didattica proposta è basata sull’osservazione diretta dei fenomeni fisici, evitando, nella fase iniziale, ogni genere di introduzione formale che possa risultare di difficile comprensione per gli studenti di SFP. Il supporto delle tecnologie didattiche ha consentito di analizzare in modo semplice e diretto i fenomeni osservati, evitando difficili calcoli o elaborazione dati.
description: Form@re - Open Journal per la formazione in rete, Vol. 16 No. 2 (2016): The teachers' expertise
An ethics instrument in teacher training: the self-assessment model “i-SAPERI”
Creators: name: Loti, Laura
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2016

description: The purpose of this paper is to provide some ideas about the importance of self-assessment process in teacher training and its ethical value, taking as example the self-assessment model “i-SAPERI”. Uno strumento etico e deontologico per la formazione dei docenti: il modello di autovalutazione “i-SAPERI” Questo contributo intende proporre alcuni spunti di riflessione circa l’importanza del processo autovalutativo nel percorso di formazione e crescita professionale dei docenti e la sua valenza etica e deontologica, assumendo come esempio il modello di autovalutazione “i-SAPERI”.
description: Form@re - Open Journal per la formazione in rete, Vol. 16 No. 2 (2016): The teachers' expertise
Towards a real-time release of blends and tablets using NIR and Raman spectroscopy at commercial scales
Creators: name: Khanolkar, Aruna
name: Thorat, Viraj
name: Patil, Bhaskar
name: Samanta, Gautam
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Near Infrared and Raman spectroscopy-based Process Analytical Technology tools were used for monitoring blend uniformity (BU) and content uniformity (CU) for solid oral formulations. A quantitative Partial Least Square model was developed to monitor BU as real-time release testing at a commercial scale. The model having the R2, and root mean square error of 0.9724 and 2.2047, respectively can predict the target concentration of 100% with a 95% confidence interval of 101.85–102.68% even after one year. The tablets from the same blends were investigated for CU using NIR and Raman techniques both in reflection and transmission mode. Raman reflection technique was found to be the best and the PLS model was developed using tablets compressed at different concentrations, hardness, and speed. The model with R2 and RMSE of 0.9766 and 1.9259, respectively was used for the quantification of CU. Both the BU and CU models were validated for accuracy, precision, specificity, linearity, and robustness. The accuracy was proved against the HPLC method with a relative standard deviation of less than 3%. The equivalency for BU by NIR and CU by Raman was evaluated using Schuirmann’s Two One-sided tests and found equivalent to HPLC within a 2% acceptable limit.
The Network of Counterparty Risk: Analysing Correlations in OTC Derivatives
Creators: name: Nanumyan, Vahan
name: Garas, Antonios
name: Schweitzer, Frank
Publisher: name: arXiv
Year: 2015
Subjects: subject: Risk Management (q-fin.RM)
subject: Physics and Society (physics.soc-ph)
subject: General Finance (q-fin.GN)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: Counterparty risk denotes the risk that a party defaults in a bilateral contract. This risk not only depends on the two parties involved, but also on the risk from various other contracts each of these parties holds. In rather informal markets, such as the OTC (over-the-counter) derivative market, institutions only report their aggregated quarterly risk exposure, but no details about their counterparties. Hence, little is known about the diversification of counterparty risk. In this paper, we reconstruct the weighted and time-dependent network of counterparty risk in the OTC derivatives market of the United States between 1998 and 2012. To proxy unknown bilateral exposures, we first study the co-occurrence patterns of institutions based on their quarterly activity and ranking in the official report. The network obtained this way is further analysed by a weighted k-core decomposition, to reveal a core-periphery structure. This allows us to compare the activity-based ranking with a topology-based ranking, to identify the most important institutions and their mutual dependencies. We also analyse correlations in these activities, to show strong similarities in the behavior of the core institutions. Our analysis clearly demonstrates the clustering of counterparty risk in a small set of about a dozen US banks. This not only increases the default risk of the central institutions, but also the default risk of peripheral institutions which have contracts with the central ones. Hence, all institutions indirectly have to bear (part of) the counterparty risk of all others, which needs to be better reflected in the price of OTC derivatives.
description: 36 pages, 18 figures, 2 tables
A Quasi-locally Most powerful Test for Correlation in the conditional Variance of Positive Data
Creators: name: McCabe, Brendan P.M.
name: Martin, Gael
name: Freeland, Keith
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: A test is derived for short-memory correlation in the conditional variance of strictly positive, skewed data. The test is quasi-locally most powerful (QLMP) under the assumption of conditionally gamma data. Analytical asymptotic relative efficiency calculations show that an alternative test, based on the first-order autocorrelation coefficient of the squared data, has negligible relative power to detect correlation in the conditional variance. Finite sample simulation results con.rm the poor performance of the squares-based test for fixed alternatives, as well as demonstrating the poor performance of the test based on the first-order autocorrelation coefficient of the raw (levels) data. Robustness of the QLMP test, both to misspecification of the conditional distribution and misspecification of the dynamics is also demonstrated using simulation. The test is illustrated using financial trade durations data.
CBS News Poll: Trump/Travel Ban/Neil Gorsuch
Creators: name: CBS News
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: President Donald Trump job performance (7); direction of country (1); the economy (1); travel ban from Muslim countries (3); refugee ban (2); Islamic religion (1); Roe vs. Wade, abortion (1); Supreme Court Justice (1); Neil Gorsuch nominated to the U.S. Supreme Court (2); personally know anyone who is Muslim (1); registered to vote (1); vote in the 2016 presidential election (1); personal finances (1); political party preference (2).
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug
Creators: name: Varghese, Sophia
name: Chaudhary, Jai Prakash
name: Thareja, Prachi
name: Ghoroi, Chinmay
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer

description: A newly developed iron-based nano-biocomposite (nano Fe-CNB) impregnated alginate formulation (CA) is proposed to improve drug loading and exhibit pH-responsive behavior of model anti-inflammatory drug-ibuprofen for controlled release applications. The proposed formulation is investigated with conventional β-CD addition in CA. The nano Fe-CNB-based formulations with and without β-CD, (Fe-CNB β-CD CA and Fe-CNB CA) are compared with only CA and β-CD incorporated CA formulations. The results indicate the incorporation of nano-biocomposite or β-CD into CA enhances the drug loading (>40%). However, pH-responsive controlled release behavior is observed for nano Fe-CNB based formulations only. The release studies from Fe-CNB β-CD CA indicate ∼ 45% release in stomach pH (1.2) within 2 h. In contrast, Fe-CNB CA shows ∼20% release only in stomach pH and improved release (∼49%) at colon pH (7.4). The rheology and swelling studies indicate Fe-CNB CA remains intact in stomach pH with a minimal drug release, but it disintegrates at colon pH due to charge reversal behavior of nano-biocomposite and ionization of polymeric chains. Thus, Fe-CNB CA formulation is found to be a potential candidate for targeting colon delivery, inflammatory bowel disease, and post-operative conditions.
Studies on pomegranate seed oil enriched galantamine hydrobromide microemulsion: formulation, in vitro antioxidant and neuroprotective potential
Creators: name: Shrivas, Meenakshee
name: Khunt, Dignesh
name: Shrivas, Meera
name: Misra, Manju
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Neuroscience
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Pomegranate seed oil with its high levels of phenolic compounds is known to exhibit neuroprotective effects. Delivering hydrophilic drugs to the brain is challenging since blood–brain barrier allows only a few lipophilic molecules into the brain, thus posing an additional barrier for drug delivery to the brain in conditions like Alzheimer’s. The present study focuses on the preparation of the stable galantamine hydrobromide (GHBr) microemulsion (ME) using pomegranate seed oil (PSO) as an adjuvant. The developed ME was characterized for various physicochemical properties, cytotoxicity, and protective role against Amyloid Beta (1–42) oligomer-induced toxicity in IMR 32 cell line. GHBr and PSO ratio was optimized based on an in-vitro diffusion study and compatibility study using DSC and FTIR. The ME was prepared by the water titration method and optimized using the one variable at a time (OVAT) strategy. Globule size and PDI of GHBr PSO ME were found to be 200.36 ± 0.01 nm, and 0.219 ± 0.011 nm respectively. GHBr PSO ME showed significantly better results in terms of cell line toxicity, antioxidant activity and protective effect against Aβ induced cell death. The results obtained showed the potential of using PSO as an effective synergistic agent along with the anti-Alzheimer’s drug for the treatment of disease.
G-virial: Gravity-based structure analysis of molecular clouds
Creators: name: Li, Guang-Xing
name: Wyrowski, Friedrich
name: Menten, Karl
name: Megeath, Tom
name: Shi, Xun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the G-virial method (available at http://gxli.github.io/G-virial/) which aims to quantify (1) the importance of gravity in molecular clouds in the position-position-velocity (PPV) space, and (2) properties of the gas condensations in molecular clouds. Different from previous approaches that calculate the virial parameter for different regions, our new method takes gravitational interactions between all the voxels in 3D PPV data cubes into account, and generates maps of the importance of gravity. This map can be combined with the original data cube to derive relations such as the mass-radius relation. Our method is important for several reasons. First, it offers the the ability to quantify the centrally condensed structures in the 3D PPV data cubes, and enables us to compare them in an uniform framework. Second, it allows us to understand the importance of gravity at different locations in the data cube, and provides a global picture of gravity in clouds. Third, it offers a robust approach to decomposing the data into different regions which are gravitationally coherent. To demonstrate the application of our method we identified regions from the Perseus and Ophiuchus molecular clouds, and analyzed their properties. We found an increase in the importance of gravity towards the centers of the individual molecular condensations. We also quantified the properties of the regions in terms of mass-radius and mass-velocity relations. Through evaluating the virial parameters based on the G-virial, we found that all our regions are almost gravitationally bound. Cluster-forming regions appear are more centrally condensed.
description: Accepted by A&A
MAJIS Shutter QM and FM Thermo-vacuum Test Report
Creators: name: STEFANI, STEFANIA
name: PICCIONI, GIUSEPPE
name: BIONDI, David
name: BOCCACCINI, Angelo
Publisher: name: IAPS Roma
Year: 2023

description: This test report provides a summary of the Thermo-Vacuum Test results on the QM and FM shutter units, a mechanical part of the spectrometer MAJIS (Moon And Jupiter Imaging Spectrometer), a payload instrument on board of the JUCE (JUpiter ICy moons Explorer) mission. The shutter actuator is composed by an electromagnetic brushless actuator mounted with an aluminium blade. The aims of the actuator are to maintain the blade in two stable positions (open and closed), to rotate the blade from one position to other in a time less than 300ms and a low power consumption. These tests have been conducted to demonstrate the capability of the shutter to operate according to requirements in vacuum at predefined temperature conditions. The target temperatures for the QM model are Top-Min = 100K and Top-Max = 165K and pressures less than 1 mbar. A total number of thermo-vacuum cycles of 42 are requested, including an extra hot point at 337K but only for the first cycle at the beginning. A slope of 2.7K/min has been agreed and planned for all the cycles. For the life test, performed only on the QM1, selected as reference, a total number of 1500 cycles at the same conditions of T and P are requested. For what concerns the test performed on the FM model, the target temperature is Top-Min = 105K and Top-Max = 160K. A total number of thermo-vacuum cycles of 4 are requested, including an extra hot point at 337K but only for the first cycle at the beginning. A slope of 2.7K/min has been agreed and planned for all the cycles.
In-cell thermodynamics and a new role for protein surfaces
Creators: name: Gorensek, Annelise H.
name: Zhou, Larry Z.
name: Smith, Austin E.
name: Senske, Michael
name: Pielak, Gary J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Understanding protein thermodynamics as it occurs inside cells is a fundamental goal of biophysics, and, from a practical point of view, will facilitate the design and improvement of protein-based drugs and catalysts. By measuring the temperature dependence of protein stability inside Escherichia coli cells, we show, contrary to predictions, that proteins are not necessarily stabilized inside cells compared with buffer alone. We also show that crowding-induced charge–charge interactions slow folding because of preferential interactions with the unfolded ensemble, and reducing these interactions increases protein stability.
Exploiting itraconazole-loaded nanomixed micelles in coated capsules as efficient colon-targeted delivery system for improved antifungal and potential anticancer efficacy
Creators: name: Adel, Shery
name: Fahmy, Rania Hassan
name: Elsayed, Ibrahim
name: Mohamed, Magdy Ibrahim
name: Ibrahim, Reem R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Chronic Inflammatory bowel diseases are usually accompanied by opportunistic colonic fungal infections. Itraconazole (ITZ), is a highly lipophilic broad-spectrum antifungal drug that is superiorly effective against several fungal species. Box-Behnken design was adopted to design ITZ-nanomixed micelles (ITZ-NMMs), aiming to enhance ITZ solubility, using various concentrations of Pluronic® L121, Cremophor EL, and with either sodium-deoxycholate or Pluronic® F68 through thin film hydration technique. Optimized formula composed of 90 % Pl–L121, 9.1% Cremophor EL, 3.127 % ITZ concentration and SDC as the hydrophilic surfactant and its particle size, Polydispersity index, zeta potential, entrapment efficiency, and release extent after 3 h were found to be 17.82 ± 0.189 nm, 0.26 ± 0.014, -6.72 ± 0.725 mV, 66 ± 7.4%, and 96.3 ± 7.22%, respectively. In vitro ITZ release study implied the ability of optimal ITZ-NMMs to enhance ITZ solubility in comparison to ITZ suspension. Also, augmented anti-fungal and anti-cancer activities were proven as ITZ-NMMs IC50 was 16.5 times that of pure ITZ. Afterwards, lyophilized optimal ITZ-NMMs formula was loaded into Eudragit S100-coated capsules where in vitro release and in vivo X-ray imaging ensured protection of ITZ release in either the stomach or intestine and targeting it to the colon. Such results suggested promising ITZ-NMMs system, capable of enhancing ITZ solubility in the intended target site, therefore, can be used not only in the treatment of colon fungal infections but also augments colon cancer therapy.
Train teachers to transform the didactic practices. A case study
Creators: name: Pentucci, Maila
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2016

description: What device for in-service teacher training could significantly and deeply change the didactic practices and their underlying conceptualization? The issue presents a longitudinal case study, made by a team of researchers with a primary school teacher, according to the Recherche Collaborative, Analyse Plurielle and Analyse de Pratique fundamentals (Lenoir, 2012; Vinatier & Altet, 2008). The research shows the transformations emerged both at the level of the transposition and didactic design, both at the level of destructuring and restructuring patterns of action.The recursive co-analysis of didactic action, systematized by a detailed protocol to collect and to investigate the data, allowed the teacher to take a reflective attitude. Following this, she has been able to incorporate, into her professional profile, the reflection on the action. She has put into practice a real type of transformative learning. Formare gli insegnanti per trasformare le pratiche didattiche. Uno studio di caso Quale dispositivo per la formazione in servizio degli insegnanti potrebbe contribuire ad un cambiamento significativo e profondo nelle pratiche didattiche e nelle concettualizzazioni ad esse sottese? L’articolo presenta un caso di studio longitudinale, condotto da un team di ricercatrici con un’insegnante di scuola primaria, secondo i principi della Ricerca Collaborativa (Lenoir, 2012) e dell’Analisi Plurale delle pratiche (Vinatier & Altet, 2008) che mostra i processi di trasformazione emersi sia a livello di trasposizione didattica e di progettazione, sia a livello di destrutturazione e ristrutturazione degli schemi d’azione propri del soggetto. La co-analisi ricorsiva dell’azione, sistematizzata da un protocollo articolato di raccolta e indagine sui dati, ha permesso all’insegnante di assumere una postura riflessiva che le ha consentito di incorporare la riflessione sull’azione nel suo profilo professionale, mettendo in atto un tipo di apprendimento realmente trasformativo.
description: Form@re - Open Journal per la formazione in rete, Vol. 16 No. 2 (2016): The teachers' expertise
Un tema e un plugin Wordpress per i siti web delle strutture INAF
Creators: name: MALASPINA, MARCO
Publisher: name: OAS Bologna
Year: 2023

description: Si ringrazia Amedeo Petrella dell’INAF di Padova per la consulenza fornita sull'uso della API di ePAS.
description: In questo report vengono presentate le funzionalità del tema “Navile” e del plugin “Oasbo”, due pacchetti software per il CMS Wordpress – già utilizzati per i siti di OAS Bologna (www.oasbo.inaf.it) e IRA Bologna (info.ira.inaf.it) – progettati e sviluppati per rispondere alle esigenze comuni a un sito web di una struttura INAF.
Digital Education Research (DER) as a theoretical/empirical bridge between research and training
Creators: name: Parola, Alberto
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2016

description: The article intends to propose an epistemological and methodological approach, called Digital Education Research (DER), which considers the “digital world” as the complexification of reality, suggesting inedited observation and assessment modality as part of educational research and teaching. This approach inevitably borrows issues, paradigms and methods of different disciplines (especially the intersubjectivity concept filtered from the psychological, anthropology and neuroscience theories lenses) applying them to learning situations, which require the use of digital media. In this sense, teacher education needs a restructuration that guides design practices towards teaching to enable them to strengthen their capacity to formulate hypotheses and bring out evidences, in activities related to action research strategies that can accommodate mixed methods research, confirming scientific dignity to the various nature and origin data, unstructured, textual and audiovisual. La Digital Education Research (DER) come ponte teorico/empirico tra ricerca e formazione L’articolo intende proporre un approccio epistemologico e metodologico, denominato digital education research, che considera il “mondo digitale” come una dimensione di complessificazione del reale, suggerendo modalità di osservazione e valutazione inedite nell’ambito della ricerca educativa e nell’insegnamento. Tale approccio inevitabilmente mutua temi, paradigmi e metodi di differenti discipline (in special modo il concetto di “intersoggettività” filtrata dalle lenti di teorie psicologiche, antropologiche e neuroscientifiche) applicandoli ai contesti apprenditivi, che richiedono l’uso dei media digitali. In tal senso, la formazione degli insegnanti necessita di una ristrutturazione che orienta le pratiche progettuali verso una didattica che consenta loro di potenziare le capacità di formulare ipotesi e far emergere evidenze, in attività riferibili a strategie di ricerca-azione che possano accogliere metodi misti di ricerca, confermando dignità scientifica a dati di varia natura e provenienza, strutturati, testuali e audiovisivi.
description: Form@re - Open Journal per la formazione in rete, Vol. 16 No. 2 (2016): The teachers' expertise
Building a doped Mott system by holography
Creators: name: Ling, Yi
name: Liu, Peng
name: Niu, Chao
name: Wu, Jian-Pin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct a holographic model in the framework of Q-lattices whose dual exhibits metal-insulator transitions. By introducing an interacting term between the Q-lattice and the electromagnetic field in bulk geometry, we find such kind of transition can be Mott-like. The evidences are presented as follows. i) The transition from a metallic phase to an insulating phase occurs when the lattice constant becomes larger. ii) A hard gap in the insulating phase can be manifestly observed in the optical conductivity. Nevertheless, in the zero temperature limit this model exhibits novel metallic behavior, featured by a gap as well as a zero-frequency mode with tiny spectral weight. It implies that our model is dual to a doped Mott system in one dimension where umklapp scattering is frozen at zero temperature. The similarity between this model and some organic linear chain conductors is briefly discussed.
description: 14 pages, 6 figures
Additional file 2 of First hip hemiarthroplasty in a Göttingen Minipig; surgical and post-mortem protocol
Creators: name: Hartmann, Katrine Top
name: Odgaard, Anders
name: Knudsen, Ulrik Kragegaard
name: Aalbæk, Bent
name: Kvich, Lasse
name: Birch, Julie Melsted
name: Petersen, Andreas
name: Bjarnsholt, Thomas
name: Jensen, Henrik Elvang
name: Jensen, Louise Kruse
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Supplementary file 2.
Characterization of co-amorphous carvedilol–maleic acid system prepared by solvent evaporation
Creators: name: Furuishi, Takayuki
name: Sato-Hata, Nanami
name: Fukuzawa, Kaori
name: Yonemochi, Etsuo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The aim of this study was to enhance the solubility and stability of the water-insoluble drug carvedilol (CAR) with maleic acid (MLE) to create a co-amorphous system by a solvent evaporation method. Phase diagrams of co-amorphous CAR–MLE, constructed from peak height in the Fourier-transform infrared (FTIR) spectra and the glass transition temperature (Tg) from differential scanning calorimetry (DSC) measurements, revealed that the optimal molar ratio of CAR to MLE was 2:1. The FTIR spectra indicated that the secondary amine-derived peak of CAR and the carboxy group-derived peak of MLE disappeared in the CAR:MLE (2:1) co-amorphous system. DSC measurements showed that the endothermic peaks associated with the melting of CAR and MLE disappeared and a Tg at 43 °C was apparent. Furthermore, the solubility of CAR tested using the shaking flask method for 24 h at 37 °C was 1.2 μg/mL, whereas that of the co-amorphous system was approximately three times higher, at 3.5 μg/mL. Finally, the stability was evaluated by powder- X-ray diffraction at 40 °C; no clear diffraction peaks originating from crystals were observed in the amorphous state until after approximately three months of storage. These results indicate that co-amorphization of CAR with MLE improved the solubility of CAR while maintaining its stability in an amorphous form.
A scale for assessing Italian schools and classes inclusiveness
Creators: name: Cottini, Lucio
name: Fedeli, Daniele
name: Morganti, Annalisa
name: Pascoletti, Stefano
name: Signorelli, Alessia
name: Zanon, Francesca
name: Zoletto, Davide
Publisher: name: Form@re - Open Journal per la formazione in rete
Year: 2016

description: The paper presents in detail the procedures for developing and validating a tool for assessing the inclusive process pertaining to school contexts called “Inclusive Process Assessment Scale”. The Scale, which is the outcome of the joined work of the authors, sets itself both as an assessing and self-assessing tool, useful for allowing on one hand specific types of evaluation and, on the other, promoting thoughts on inclusive education’s quality indicators, thus contributing to the planning and ongoing adjustment of the educational project of the school and the class. The tool, in its computer version as well, allows for the planning of researches that can collect evidences supporting the full inclusion organization of Italian schools. Una scala per valutare l’inclusività delle scuole e delle classi italiane Il contributo presenta in dettaglio le procedure di costruzione e validazione di uno strumento per valutare i processi inclusivi riferiti ai contesti scolastici, chiamato “Scala di Valutazione dei Processi Inclusivi”. Frutto del lavoro congiunto svolto dagli autori, la Scala si pone come uno strumento valutativo e autovalutativo utile a consentire da un lato, la realizzazione di specifiche forme di misurazione e, dall’altro, la promozione di processi di riflessione sugli indicatori di qualità dell’educazione inclusiva, per contribuire alla progettazione e alla regolazione in itinere del progetto educativo della scuola e della classe. Lo strumento, anche nella sua versione digitale, consente di pianificare ricerche, che possono raccogliere evidenze in grado di avvalorare l’organizzazione scolastica italiana di full inclusion.
description: Form@re - Open Journal per la formazione in rete, Vol. 16 No. 2 (2016): The teachers' expertise
A structural equation model of adverse events and length of stay in hospitals
Creators: name: Hauck, Katharina
name: Zhao, Xueyan
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Adverse events in hospitals cause significant morbidity and mortality, and considerable effort has been invested into analysing their incidence and preventability. An unresolved issue in models of medical adverse events is potential endogeneity of length of stay (LOS): whilst the probability of suffering a medical adverse event during the episode is likely to increase as a patient stays longer, there are a range of unobservable patient and hospital factors affecting both the occurrence of adverse events and LOS, such as unobserved patient complexity and hospital management. Therefore, statistical models of adverse events which do not account for the potential endogeneity of LOS may generate biased estimates. Our objective is to examine the effects of risk factors on the incidence of adverse events using structural equation models and accounting for endogeneity of LOS. We estimate separate models for three of the most common and serious types of medical adverse events: adverse drug reactions, hospital acquired infections, and pressure ulcers. We use episode level administrative hospital data from public hospitals in the state of Victoria, Australia, for the years 2004/05 and 2005/06 with detailed information on patients, in particular medical complexity and adverse events suffered during admission. We use days and months of discharge as instruments for LOS. Our research helps assessing the costs and benefits of additional days spent in hospital. For example, it can contribute to identifying the ideal time of discharge of patients, or inform whether 'hospital at home' programs reduce rates of hospital acquired infections.
title: Kommunikation von Unsicherheit in schriftlichen Gesundheitsinformationen: eine randomisierte Studie
Creators: name: Büchter, Roland Brian
name: Betsch, Cornelia
name: Ehrlich, Martina
name: Fechtelpeter, Dennis
name: Grouven, Ulrich
name: Keller, Sabine
name: Meuer, Regina
name: Rossmann, Constanze
name: Waltering, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Unsicherheit ist bei medizinischen Entscheidungen unvermeidlich und gerade bei präferenz-sensitiven Entscheidungen von Bedeutung. Evidenzbasierte Gesundheitsinformationen sollen neben Behandlungseffekten auch damit verbundene Unsicherheiten vermitteln. Wir haben [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: EbM und Digitale Transformation in der Medizin; 20. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Erratum to: Study of B s 0 $$ {\mathrm{B}}_{\mathrm{s}}^0 $$ → J/ψπ+π−K+K− decays
Creators: name: More Than 100 Authors
Publisher: name: My University
Year: 2021

description: For a complete list of authors, please look at article.
description: The original article has been corrected.
title: Stewart Bar Mining Project
titleType: AlternativeTitle
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson–Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Stewart Bar Mining Project on the Middle Fork Eel River
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2023

description: WCRO-2022-01927
Il tour virtuale al Museo La Specola dell'Osservatorio Astronomico di Padova
Creators: name: ZANINI, Valeria
name: DI GIACOMO, FEDERICO
name: DIMA, Marco
Publisher: name: O.A. Padova
Year: 2023

description: Il rapporto descrive la procedura seguita per realizzare il tour virtuale del Museo 'La Specola', sezione museale dell’Osservatorio Astronomico di Padova: si tratta di un percorso museale accessibile a tutti tramite smartphone, tablet e pc. Esso si snoda attraverso sette diverse ‘stanze virtuali’, nelle quali si è accompagnati dalle voci-guida di Valeria Zanini e Federico Di Giacomo, che descrivono gli ambienti e gli strumenti utilizzati dagli astronomi padovani dei secoli passati. Grazie alle didascalie, si possono ottenere informazioni aggiuntive di approfondimento, mentre alcuni video e ricostruzioni 3D permettono di conoscere storie e aneddoti che fanno di questo luogo uno dei principali centri dell’astronomia italiana. Valeria Zanini, responsabile scientifica del patrimonio storico dell’Osservatorio, ha curato il percorso di visita; Federico Di Giacomo è il responsabile della progettazione e della realizzazione grafica del virtual tour; Marco Dima ha realizzato le immagini 360° e video 3D della linea meridiana.
Erratum: Search for new non-resonant phenomena in high-mass dilepton final states with the ATLAS detector
Creators: name: More Than 100 Authors
Publisher: name: My University
Year: 2021

description: For a complete list of authors, please look at article.
description: The Lagrangian in eq. (2.1) of JHEP 11 (2020) 005 has an erroneous factor of 1/2. The analysis code used for the results reported in the paper does not have this factor. The results remain unchanged.
Vertical integration in agribusiness. Is it a bargain?
Creators: name: Carillo, Felicetta
name: Caracciolo, Francesco
name: Cembalo, Luigi
Publisher: name: Italian Review of Agricultural Economics
Year: 2016

description: This paper aims to test whether vertical integrated farms show a significant higher economic performance when compared with those not integrated. The Italian Farm Accountancy Data Network was used, for the years 2008-2011, focusing on farms producing durum wheat. Empirically, a propensity score-matching model was implemented in an attempt to estimate average differences, in some farm performance indexes, including costs and profitability, between vertical integrated and non-integrated farms. The analysis on the effects of a vertical integration showed that supply chain integration increases farms' competiveness and profitability.)
description: Italian Review of Agricultural Economics, Vol 71 No 1 (2016): Vol 71, No 1 (Suppl.) (2016)
SLab Data Manager
Creators: name: CARRARO, Francesco
name: CARLI, CRISTIAN
name: BRUSCHINI, Enrico
Publisher: name: IAPS Roma
Year: 2023

description: The authors acknowledge the support of MELODY: Moon multisEnsor and LabOratory Data analYsis project, PRIN INAF (RIC) 2019, (Fu. Ob.: 1.05.01.85.17, CRA 1.20), P.I. Federico Tosi; the Ol-BODIES project, ASI-INAF n.2018-16-HH.0
description: The SLab Data Manager is a tool developed for helping activities in IAPS SLab structure. The app has the main goal of allowing researchers in processing and saving spectra saved during the acquisition sessions. Several kinds of processing tools have been made available to create a flexible and useful tool. In this user manual it will be explained how to use the application for acquiring spectra, for processing them and saving raw and processed spectra into the SLab database (DB in the following).