cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor
Creators: name: Smith, C.C.
name: Sun, C.
name: Vincent, B.G.
name: Dotti, G.
name: Savoldo, B.
name: Metelitsa, L.S.
name: Chen, Y.
name: Landoni, E.
name: Fuca, G.
Publisher: name: American Association for Cancer Research Inc.
Year: 2020

description: T-cell receptor (TCR) gene transfer redirects T cells to target intracellular antigens. However, the potential autoreactivity generated by TCR mispairing and occurrence of graft-versus-host disease in the allogenic setting due to the retention of native TCRs remain major concerns. Natural killer T cells (NKT) have shown promise as a platform for adoptive T-cell therapy in cancer patients. Here, we showed their utility for TCR gene transfer. We successfully engineered and expanded NKTs expressing a functional TCR (TCR NKTs), showing HLA-restricted antitumor activity in xenogeneic mouse models in the absence of graft-versus-mouse reactions. We found that TCR NKTs downregulated the invariant TCR (iTCR), leading to iTCR+TCR+ and iTCR-TCR+ populations. In-depth analyses of these subsets revealed that in iTCR-TCR+ NKTs, the iTCR, although expressed at the mRNA and protein levels, was retained in the cytoplasm. This effect resulted from a competition for binding to CD3 molecules for cell-surface expression by the transgenic TCR. Overall, our results highlight the feasibility and advantages of using NKTs for TCR expression for adoptive cell immunotherapies. NKT-low intrinsic alloreactivity that associated with the observed iTCR displacement by the engineered TCR represents ideal characteristics for “off-the-shelf” products without further TCR gene editing.
Theoretical study of laser intensity noise effect on CW-STED microscopy
Creators: name: Mendoza-Coto, Alejandro
name: Jaime, Danay Manzo
name: Mellor, Ariel Francis Pérez
name: Hernández, Iván Coto
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Spatial resolution of stimulated emission depletion (STED) microscopy varies with sample labeling techniques and microscope components, e.g., lasers, lenses, and photo-detectors. Fluctuations in the intensity of the depletion laser decrease achievable resolution in STED microscopy; the stronger the fluctuations, the higher the average intensity needed to achieve a given resolution. This phenomenon is encountered in every STED measurement. However, a theoretical framework that evaluates the effect of intensity fluctuations on spatial resolution is lacking. This article presents an analytical formulation based on a stochastic model that characterizes the impact of the laser fluctuations and correlation time on the depletion efficiency in the continuous wave (CW) STED microscopy. We compared analytical results with simulations using a wide range of intensity noise conditions and found a high degree of agreement. The stochastic model used considers a colored noise distribution for the laser intensity fluctuations. Simple analytical expressions were obtained in the limit of small and large fluctuations correlation time. These expressions fitted very well the available experimental data. Finally, this work offers a starting point to model other laser noise effects in various microscopy implementations.
description: 6 pages, 4 figures, Accepted as a regular article at JOSAA
Presenting Finite Posets
Creators: name: Mimram, Samuel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We introduce a monoidal category whose morphisms are finite partial orders, with chosen minimal and maximal elements as source and target respectively. After recalling the notion of presentation of a monoidal category by the means of generators and relations, we construct a presentation of our category, which corresponds to a variant of the notion of bialgebra.
description: In Proceedings TERMGRAPH 2014, arXiv:1505.06818
Platyrrhinus ismaeli Velazco 2005
Creators: name: Wilson, Don E.
name: Mittermeier, Russell A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Phyllostomidae
Platyrrhinus
Platyrrhinus ismaeli

description: 181. Ismael’s Broad-nosed Bat Platyrrhinus ismaeli French: Sténoderme d’Ismael / German: Ismael-Breitnasenfledermaus / Spanish: Platirrino de Ismael Taxonomy. Platyrrhinus ismaeli Velazco, 2005, “ 19 km E:of Balsas, 1945 m (6380 ft) in elevation, Province of Chachapoyas, Department of Amazonas, Peru.” Platyrrhinus ismaeli was previously included in P. dorsalis, but morphologic and morphometric analyses proved their distinction. Monotypic. Distribution. SW Colombia, Ecuador, and NC Peru. Descriptive notes. Head-body 79-84 mm (tailless), ear 20-22 mm, hindfoot 13-18 mm, forearm 52-56 mm; weight 30-40 g. Ismael’s Broad-nosed Bat is medium-sized. Dorsal fur is dark brown, ventral furis grayish, and dorsal and ventral hairs are tricolored. Dorsal hairs are long (8-10 mm). Head is robust, snout is short and broad, and facialstrips are darkish, supraocular just a bit brighter than subocular. Dorsalstripe is narrow but brighter than facial ones. Noseleaf is large and spearshaped; its edges are dark, never bright yellowish or cream, and lower rim is free. Folds on ears are absent to poorly marked (this can be variable). Insertion of posterior edge of plagiopatagium occurs on first metatarsal, and third metacarpal is shorter than fifth. Caudal membraneis very short in middle, with deep V-shaped groove; edge has dense fringe of short hairs. Dense and long hair occurs on dorsum offeet. I' converge, are in contact at tips, and are twice as long as I2. P* has two stylar cusps on its posterior face. M' metastyle is present, and protocone is small and blunt. Habitat. Pre-montane and montane humid forests of Andean slopes, secondary forests, and plantations at elevations of 1230-2950 m. Food and Feeding. There is no specific information available for Ismael’s Broad-nosed Bat, but other broad-nosed bats feed heavily on fruits. Breeding. Pregnant Ismael’s Broad-nosed Bat have been found in January and March in eastern Ecuador and February in Colombia. Activity patterns. Ismael’s Broad-nosed Bat is nocturnal. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Near Threatened on The IUCN Red List. Ismael’s Broad-nosed Batis at risk of population decline because habitat quality and extent continue to decline. Natural history information is lacking. Bibliography. Gardner (2008c), Rengifo et al. (2011), Velazco (2005), Velazco & Gardner (2009), Velazco & Patterson (2008), Velazco & Solari (2003).
description: Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Phyllostomidae, pp. 444-583 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on pages 567-568, DOI: 10.5281/zenodo.6458594
(4159) Ruth [Oxley]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Big image of Galois representations associated with finite slope $p$-adic families of modular forms
Creators: name: Conti, Andrea
name: Iovita, Adrian
name: Tilouine, Jacques
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We consider the Galois representation associated with a finite slope $p$-adic family of modular forms. We prove that the Lie algebra of its image contains a congruence Lie subalgebra of a non-trivial level. We describe the largest such level in terms of the congruences of the family with $p$-adic CM forms.
description: 23 pages; revision of Section 2 (see Remark 2.4) and improvement of Proposition 4.14, plus minor changes. Published in "Elliptic Curves, Modular Forms and Iwasawa Theory. In Honour of John H. Coates' 70th Birthday, Cambridge, UK, March 2015", Springer Proceedings in Mathematics & Statistics, Vol. 188, 2016
Fractional Wigner crystal in the helical Luttinger liquid
Creators: name: Ziani, N. Traverso
name: Crépin, F.
name: Trauzettel, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The properties of the strongly interacting edge states of two dimensional topological insulators in the presence of two particle backscattering are investigated. We find an anomalous behavior of the density-density correlation functions, which show oscillations that are neither of Friedel nor of Wigner type: they instead represent a Wigner crystal of fermions of fractional charge e/2, with e the electron charge. By studying the Fermi operator, we show that the state characterized by such fractional oscillations still bears the signatures of spin momentum locking. Finally, we compare the spin-spin correlation functions and the density-density correlation functions to argue that the fractional Wigner crystal is characterized by a non trivial spin texture.
description: 5 pages, 2 figures
Triangularizability of trace-class operators with increasing spectrum
Creators: name: Drnovšek, Roman
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47A15, 47A46, 47B10, 47B34, 47B65

description: For any measurable set $E$ of a measure space $(X, μ)$, let $P_E$ be the (orthogonal) projection on the Hilbert space $L^2(X, μ)$ with the range $ran \, P_E = \{f \in L^2(X, μ) : f = 0 \ \ a.e. \ on \ E^c\}$ that is called a standard subspace of $L^2(X, μ)$. Let $T$ be an operator on $L^2(X, μ)$ having increasing spectrum relative to standard compressions, that is, for any measurable sets $E$ and $F$ with $E \subseteq F$, the spectrum of the operator $P_E T|_{ran \, P_E}$ is contained in the spectrum of the operator $P_F T|_{ran \, P_F}$. In 2009, Marcoux, Mastnak and Radjavi asked whether the operator $T$ has a non-trivial invariant standard subspace. They answered this question affirmatively when either the measure space $(X, μ)$ is discrete or the operator $T$ has finite rank. We study this problem in the case of trace-class kernel operators. We also slightly strengthen the above-mentioned result for finite-rank operators.
Photometric defocus observations of transiting extrasolar planets
Creators: name: Hinse, Tobias C.
name: Han, Wonyong
name: Yoon, Jo-Na
name: Lee, Chung-Uk
name: Kim, Yong-Gi
name: Kim, Chun-Hwey
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We have carried out photometric follow-up observations of bright transiting extrasolar planets using the CbNUOJ 0.6m telescope. We have tested the possibility of obtaining high photometric precision by applying the telescope defocus technique allowing the use of several hundred seconds in exposure time for a single measurement. We demonstrate that this technique is capable of obtaining a root-mean-square scatter of order sub-millimagnitude over several hours for a V $\sim$ 10 host star typical for transiting planets detected from ground-based survey facilities. We compare our results with transit observations with the telescope operated in in-focus mode. High photometric precision is obtained due to the collection of a larger amount of photons resulting in a higher signal compared to other random and systematic noise sources. Accurate telescope tracking is likely to further contribute to lowering systematic noise by probing the same pixels on the CCD. Furthermore, a longer exposure time helps reducing the effect of scintillation noise which otherwise has a significant effect for small-aperture telescopes operated in in-focus mode. Finally we present the results of modelling four light-curves for which a root-mean-square scatter of 0.70 to 2.3 milli-magnitudes have been achieved.
description: 12 pages, 11 figures, 5 tables. Submitted to Journal of Astronomy and Space Sciences (JASS)
(4161) George Percy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Needed Computations Shortcutting Needed Steps
Creators: name: Antoy, Sergio
name: Johannsen, Jacob
name: Libby, Steven
Publisher: name: arXiv
Year: 2015
Subjects: subject: Programming Languages (cs.PL)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: D.3.3;D.3.4;F.4.2;G.2.2

description: We define a compilation scheme for a constructor-based, strongly-sequential, graph rewriting system which shortcuts some needed steps. The object code is another constructor-based graph rewriting system. This system is normalizing for the original system when using an innermost strategy. Consequently, the object code can be easily implemented by eager functions in a variety of programming languages. We modify this object code in a way that avoids total or partial construction of the contracta of some needed steps of a computation. When computing normal forms in this way, both memory consumption and execution time are reduced compared to ordinary rewriting computations in the original system.
description: In Proceedings TERMGRAPH 2014, arXiv:1505.06818
Quantifying and Reducing Model-Form Uncertainties in Reynolds-Averaged Navier-Stokes Simulations: A Data-Driven, Physics-Based Bayesian Approach
Creators: name: Xiao, H.
name: Wu, J. -L.
name: Wang, J. -X.
name: Sun, R.
name: Roy, C. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences
subject: 76F99

description: Despite their well-known limitations, Reynolds-Averaged Navier-Stokes (RANS) models are still the workhorse tools for turbulent flow simulations in today's engineering application. For many practical flows, the turbulence models are by far the largest source of uncertainty. In this work we develop an open-box, physics-informed Bayesian framework for quantifying model-form uncertainties in RANS simulations. Uncertainties are introduced directly to the Reynolds stresses and are represented with compact parameterization accounting for empirical prior knowledge and physical constraints (e.g., realizability, smoothness, and symmetry). An iterative ensemble Kalman method is used to assimilate the prior knowledge and observation data in a Bayesian framework, and to propagate them to posterior distributions of velocities and other Quantities of Interest (QoIs). We use two representative cases, the flow over periodic hills and the flow in a square duct, to evaluate the performance of the proposed framework. Simulation results suggest that, even with very sparse observations, the posterior mean velocities and other QoIs have significantly better agreement with the benchmark data compared to the baseline results. At most locations the posterior distribution adequately captures the true model error within the developed model form uncertainty bounds. The framework is a major improvement over existing black-box, physics-neutral methods for model-form uncertainty quantification, where prior knowledge and details of the models are not exploited. This approach has potential implications in many fields in which the governing equations are well understood but the model uncertainty comes from unresolved physical processes.
description: 53 pages, 15 figures
Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors
Creators: name: Reppel, L.
name: Dotti, G.
name: Landoni, E.
name: Savoldo, B.
name: Fuca, G.
Publisher: name: American Association for Cancer Research Inc.
Year: 2020

description: Chimeric antigen receptor (CAR) T-cell therapy has been acclaimed as a revolution in cancer treatment following the impressive results in hematologic malignancies. Unfortunately, in patients with solid tumors, objectives responses to CAR T cells are still anecdotal, and important issues are driven by on-target but off-tumor activity of CAR T cells and by the extremely complex biology of solid tumors. Here, we will review the recent attempts to challenge the therapeutic impediments to CAR T-cell therapy in solid tumors. We will focus on the most promising strategies of antigen targeting to improve tumor specificity and address the tumor heterogeneity, efforts to circumvent the physical barriers of the tumor architecture such as subverted tumor vasculature, impediments of CAR T-cell trafficking and immune suppressive microenvironment.
U.S. Feed Grains: Background for 1990 Farm Legislation
Creators: name: Hoffman, Linwood
name: Ash, Mark
name: Lin, William
name: Mercier, Stephanie
name: Hoffman, Linwood
name: Ash, Mark
name: Lin, William
name: Mercier, Stephanie
Publisher: name: Unknown
Year: 1990
Subjects: subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: International Relations/Trade
subject: Livestock Production/Industries
subject: feed grains
subject: corn
subject: sorghum
subject: barley
subject: oats
subject: production
subject: domestic use
subject: farm programs
subject: farm returns
subject: prices
subject: program effects
subject: world trade

description: Feed grains (corn, sorghum, barley, and oats) lead all crops in terms of production value and acres planted. During 1988 their value of production totaled $15.3 billion, or 22 percent of all crops grown, while planted area totaled 101.6 million acres or 33 percent of principal crop acres planted. Domestic use accounts for about 73 percent of total disappearance with most going into livestock and poultry feed. Food, seed, and industrial uses claim the remaining domestic share with items such as ethanol, high fructose corn syrup, barley malt, oats bran, and other beverage and food items. Exports claim about 27 percent of total use and are important to corn, sorghum, and barley producers, but not oats. Government income and support programs are periodically vital to feed grain producers as recent government payments equaled nearly 30 percent of the crop value. Likewise, consumers and taxpayers are equally concerned over the cost of these programs. Policy issues for 1990 legislation include the level and flexibility of price and income supports, functioning of the CCC storage program and the farmer-owned reserve, acreage reduction and conservation reserve programs, programs to compensate producers for disaster, programs to enhance exports, conservation and environmental issues, and policy effects on trade, the livestock sector, resources, consumers, and taxpayers.
Relation of classical non-equilibrium dynamics and quantum annealing
Creators: name: Nishimori, Hidetosni
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Non-equilibrium dynamics of the Ising model is a classical stochastic process whereas quantum mechanics has no stochastic elements in the classical sense. Nevertheless, it has been known that there exists a close formal relationship between these two processes. We reformulate this relationship and use it to compare the efficiency of simulated annealing that uses classical stochastic processes and quantum annealing to solve combinatorial optimization problems. It is shown that classical dynamics can be efficiently simulated by quantum-mechanical processes whereas the converse is not necessarily true. This may imply that quantum annealing may be regarded as a more powerful tool than simulated annealing for optimization problems.
description: Proceedings of STATPHYS-KOLKATA VIII
title: War and Its Witnesses: International Criminal Justice and the Legal Recognition of Civilian Victims
Creators: name: Garbett, Claire Joyce
Publisher: name: Goldsmiths, University of London
Year: 2009

description: This thesis examines how international criminal justice mechanisms construct legal recognition, protection and redress of the civilian victims of armed conflict. Using the International Criminal Tribunal for the former Yugoslavia ('ICTY') as a case-study, it explores how the rules and practices of humanitarian law address and redress acts of civilian victimisation. Since the early 1990s, the United Nations has identified international criminal justice mechanisms as central to the prosecution of perpetrators of civilian victimisation. It has also increasingly understood that such mechanisms are important for their provision of 'restorative' justice to victims, including their recognition, participation and redress. This thesis examines the factors that enable or constrain the process of legally recognising civilian victims in light of this changing role of legal mechanisms. Chapters one and two outline the theoretical and methodological frameworks of the thesis. Chapters three and four analyse the protective rules of humanitarian law and the ICTY's prosecutions of civilian victimisation. A central principle of humanitarian law is that all parties to a conflict must distinguish between civilians and combatants. Civilians are all persons who are not combatants. However, this thesis argues that social categories of group membership are drawn upon and evoked during the processes of legally recognising civilian victims. It shows how the legal category of 'civilian' has been historically imbued with particular notions of nation, ethnicity and gender that can act as exclusionary categorisations. This thesis then examines how the ICTY designates 'civilian' status to individuals and collectivities by focusing on trial proceedings. Drawing on fieldwork at the ICTY, chapters five and six show that civilian victim-witnesses rarely conceive of conflict as a solitary experience, but instead view their victimisation in terms of structural and relational harms to themselves and others. However, this thesis argues that the ICTY's current form of legal practices do not establish recognition of all civilian victims nor adequately capture their collective and harmful experiences of victim is at ion in conflict situations.
Anticancer innovative therapy: Highlights from the ninth annual meeting
Creators: name: Di Nicola, M.
name: Pruneri, G.
name: Volpari, T.
name: De Braud, F.
name: Bracken, A.P.
name: Buschbeck, M.
name: Del Vecchio, M.
name: Lisanti, M.P.
name: Massaia, M.
name: De Santis, F.
name: Anichini, A.
name: Pupa, S.M.
name: Dotti, G.
name: Wegner, A.
name: Fortunato, O.
name: Di Cosimo, S.
Publisher: name: Elsevier Ltd
Year: 2020

description: The Ninth Annual Conference of “Anticancer Innovative Therapy”, organized by Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (Fondazione IRCCS INT) and hosted by Hotel Michelangelo, was held in Milan on 25 January 2019. Cutting-edge science was presented in two main scientific sessions: i) pre-clinical evidences and new targets, and ii) clinical translation. The Keynote lecture entitled “Cancer stem cells (CSCs): metabolic strategies for their identification and eradication” presented by M. Lisanti, was one of the highlights of the conference. One key concept of the meeting was how the continuous advances in our knowledge about molecular mechanisms in various fields of research (cancer metabolism reprogramming, epigenetic regulation, transformation/invasiveness, and immunology, among others) are driving cancer research towards more effective personalized antineoplastic strategies. Specifically, recent preclinical data on the following topics were discussed: 1. Polycomb group proteins in cancer; 2. A d16HER2 splice variant is a flag of HER2 addiction across HER2-positive cancers; 3. Studying chromatin as a nexus between translational and basic research; 4. Metabolomic analysis in cancer patients; 5. CDK4-6 cyclin inhibitors: clinical activity and future perspectives as immunotherapy adjuvant; and 6. Cancer stem cells (CSCs): metabolic strategies for their identification and eradication. In terms of clinical translation, several novel approaches were presented: 1. Developing CAR-T cell therapies: an update of preclinical and clinical development at University of North Carolina; 2. Vγ9Vδ2 T-cell activation and immune suppression in multiple myeloma; 3. Predictive biomarkers for real-world immunotherapy: the cancer immunogram model in the clinical arena; and 4. Mechanisms of resistance to immune checkpoint blockade in solid tumors. Overall, the pre-clinical and clinical findings presented could pave the way to identify novel actionable therapeutic targets to significantly enhance the care of persons with cancer.
(4156) Ada Blanche [Iles]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Complexity Analysis of Precedence Terminating Infinite Graph Rewrite Systems
Creators: name: Eguchi, Naohi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Complexity (cs.CC)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: I.2.2;F.1.1;F.1.3;F.4.1;

description: The general form of safe recursion (or ramified recurrence) can be expressed by an infinite graph rewrite system including unfolding graph rewrite rules introduced by Dal Lago, Martini and Zorzi, in which the size of every normal form by innermost rewriting is polynomially bounded. Every unfolding graph rewrite rule is precedence terminating in the sense of Middeldorp, Ohsaki and Zantema. Although precedence terminating infinite rewrite systems cover all the primitive recursive functions, in this paper we consider graph rewrite systems precedence terminating with argument separation, which form a subclass of precedence terminating graph rewrite systems. We show that for any precedence terminating infinite graph rewrite system G with a specific argument separation, both the runtime complexity of G and the size of every normal form in G can be polynomially bounded. As a corollary, we obtain an alternative proof of the original result by Dal Lago et al.
description: In Proceedings TERMGRAPH 2014, arXiv:1505.06818. arXiv admin note: text overlap with arXiv:1404.6196
(4158) Thomas Oxley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(4153) Frances Mary J. Iles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
In vitro elimination of epidermal growth factor receptor-overexpressing cancer cells by CD32A-chimeric receptor T cells in combination with cetuximab or panitumumab
Creators: name: Dotti, G.
name: Cenciarelli, C.
name: Caratelli, S.
name: Arriga, R.
name: Landoni, E.
name: Del Principe, M.I.
name: Venditti, A.
name: Pastore, D.
name: Ferrone, S.
name: Lanzilli, G.
name: Du, H.
name: Ottaviani, A.
name: Lauro, D.
name: Sconocchia, G.
name: Savoldo, B.
name: Sconocchia, T.
Publisher: name: Wiley-Liss Inc.
Year: 2020

description: Cetuximab and panitumumab bind the human epidermal growth factor receptor (EGFR). Although the chimeric cetuximab (IgG1) triggers antibody-dependent-cellular-cytotoxicity (ADCC) of EGFR positive target cells, panitumumab (a human IgG2) does not. The inability of panitumumab to trigger ADCC reflects the poor binding affinity of human IgG2 Fc for the FcγRIII (CD16) on natural killer (NK) cells. However, both human IgG1 and IgG2 bind the FcγRII (CD32A) to a similar extent. Our study compares the ability of T cells, engineered with a novel low-affinity CD32A131R-chimeric receptor (CR), and those engineered with the low-affinity CD16158F-CR T cells, in eliminating EGFR positive epithelial cancer cells (ECCs) in combination with cetuximab or panitumumab. After T-cell transduction, the percentage of CD32A131R-CR T cells was 74 ± 10%, whereas the percentage of CD16158F-CR T cells was 46 ± 15%. Only CD32A131R-CR T cells bound panitumumab. CD32A131R-CR T cells combined with the mAb 8.26 (anti-CD32) and CD16158F-CR T cells combined with the mAb 3g8 (anti-CD16) eliminated colorectal carcinoma (CRC), HCT116FcγR+ cells, in a reverse ADCC assay in vitro. Crosslinking of CD32A131R-CR on T cells by cetuximab or panitumumab and CD16158F-CR T cells by cetuximab induced elimination of triple negative breast cancer (TNBC) MDA-MB-468 cells, and the secretion of interferon gamma and tumor necrosis factor alpha. Neither cetuximab nor panitumumab induced Fcγ-CR T antitumor activity against Kirsten rat sarcoma (KRAS)-mutated HCT116, nonsmall-cell-lung-cancer, A549 and TNBC, MDA-MB-231 cells. The ADCC of Fcγ-CR T cells was associated with the overexpression of EGFR on ECCs. In conclusion, CD32A131R-CR T cells are efficiently redirected by cetuximab or panitumumab against breast cancer cells overexpressing EGFR.
Scaling the Yield of Laser-Driven Electron-Positron Jets to Laboratory Astrophysical Applications
Creators: name: Chen, Hui
name: Fiuza, F.
name: Link, A.
name: Hazi, A.
name: Hill, M.
name: Hoarty, D.
name: James, S.
name: Kerr, S.
name: Meyerhofer, D. D.
name: Myatt, J.
name: Park, J.
name: Sentoku, Y.
name: Williams, G. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report new experimental results obtained on three different laser facilities that show directed laser-driven relativistic electron-positron jets with up to 30 times larger yields than previously obtained and a quadratic (~ E^2) dependence of the positron yield on the laser energy. This favorable scaling stems from a combination of higher energy electrons due to increased laser intensity and the recirculation of MeV electrons in the mm-thick target. Based on this scaling, first principles simulations predict the possibility of using such electron-positron jets, produced at upcoming high-energy laser facilities, to probe the physics of relativistic collisionless shocks in the laboratory.
description: 10 pages, 3 figures. Accepted to be published on Physical Review Letters on April 23, 2015
CD16-158-valine chimeric receptor T cells overcome the resistance of KRAS-mutated colorectal carcinoma cells to cetuximab
Creators: name: Ferrone, S.
name: Lauro, D.
name: Sconocchia, G.
name: Sconocchia, T.
name: Cenciarelli, C.
name: Coppola, A.
name: Dotti, G.
name: Iezzi, G.
name: Roselli, M.
name: Spagnoli, G.C.
name: Ottaviani, A.
name: Caratelli, S.
name: Lanzilli, G.
name: Arriga, R.
Publisher: name: Wiley-Liss Inc.
Year: 2020

description: KRAS mutations hinder therapeutic efficacy of epidermal growth factor receptor (EGFR)-specific monoclonal antibodies cetuximab and panitumumab-based immunotherapy of EGFR+ cancers. Although cetuximab inhibits KRAS-mutated cancer cell growth in vitro by natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), KRAS-mutated colorectal carcinoma (CRC) cells escape NK cell immunosurveillance in vivo. To overcome this limitation, we used cetuximab and panitumumab to redirect Fcγ chimeric receptor (CR) T cells against KRAS-mutated HCT116 colorectal cancer (CRC) cells. We compared four polymorphic Fcγ-CR constructs including CD16158F-CR, CD16158V-CR, CD32131H-CR, and CD32131R-CR transduced into T cells by retroviral vectors. Percentages of transduced T cells expressing CD32131H-CR (83.5 ± 9.5) and CD32131R-CR (77.7 ± 13.2) were significantly higher than those expressing with CD16158F-CR (30.3 ± 10.2) and CD16158V-CR (51.7 ± 13.7) (p < 0.003). CD32131R-CR T cells specifically bound soluble cetuximab and panitumumab. However, only CD16158V-CR T cells released high levels of interferon gamma (IFNγ = 1,145.5 pg/ml ±16.5 pg/ml, p < 0.001) and tumor necrosis factor alpha (TNFα = 614 pg/ml ± 21 pg/ml, p < 0.001) upon incubation with cetuximab-opsonized HCT116 cells. Moreover, only CD16158V-CR T cells combined with cetuximab killed HCT116 cells and A549 KRAS-mutated cells in vitro. CD16158V-CR T cells also effectively controlled subcutaneous growth of HCT116 cells in CB17-SCID mice in vivo. Thus, CD16158V-CR T cells combined with cetuximab represent useful reagents to develop innovative EGFR+KRAS-mutated CRC immunotherapies.
(4154) Amy Kathleen Iles Iles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An Implementation Model for Interaction Nets
Creators: name: Hassan, Abubakar
name: Mackie, Ian
name: Sato, Shinya
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: To study implementations and optimisations of interaction net systems we propose a calculus to allow us to reason about nets, a concrete data-structure that is in close correspondence with the calculus, and a low-level language to create and manipulate this data structure. These work together so that we can describe the compilation process for interaction nets, reason about the behaviours of the implementation, and study the efficiency and properties.
description: In Proceedings TERMGRAPH 2014, arXiv:1505.06818
(4155) William Frederick Blanshard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma
Creators: name: Lulla, P.D.
name: Park, S.I.
name: Savoldo, B.
name: Buchanan, F.B.
name: Brenner, M.K.
name: Shea, T.C.
name: Ivanova, A.
name: Rooney, C.M.
name: Dotti, G.
name: Wang, T.
name: Wu, M.-F.
name: Cheng, C.J
name: Gee, A.P.
name: Mehta, B.
name: Dittus, C.
name: Ramos, C.A.
name: Grover, N.S.
name: Grilley, B.J.
name: Beaven, A.W.
name: Eldridge, P.W.
name: Heslop, H.E.
name: Serody, J.S.
name: Morrison, K.
name: McKay, K.L.
Publisher: name: American Society of Clinical Oncology
Year: 2020

description: PURPOSE Chimeric antigen receptor (CAR) T-cell therapy of B-cell malignancies has proved to be effective. We show how the same approach of CAR T cells specific for CD30 (CD30.CAR-Ts) can be used to treat Hodgkin lymphoma (HL). METHODS We conducted 2 parallel phase I/II studies (ClinicalTrials.gov identifiers: NCT02690545 and NCT02917083) at 2 independent centers involving patients with relapsed or refractory HL and administered CD30.CAR-Ts after lymphodepletion with either bendamustine alone, bendamustine and fludarabine, or cyclophosphamide and fludarabine. The primary end point was safety. RESULTS Forty-one patients received CD30.CAR-Ts. Treated patients had a median of 7 prior lines of therapy (range, 2-23), including brentuximab vedotin, checkpoint inhibitors, and autologous or allogeneic stem cell transplantation. The most common toxicities were grade 3 or higher hematologic adverse events. Cytokine release syndrome was observed in 10 patients, all of which were grade 1. No neurologic toxicity was observed. The overall response rate in the 32 patients with active disease who received fludarabine-based lymphodepletion was 72%, including 19 patients (59%) with complete response. With a median follow-up of 533 days, the 1-year progression-free survival and overall survival for all evaluable patients were 36% (95% CI, 21% to 51%) and 94% (95% CI, 79% to 99%), respectively. CAR-T cell expansion in vivo was cell dose dependent. CONCLUSION Heavily pretreated patients with relapsed or refractory HL who received fludarabine-based lymphodepletion followed by CD30.CAR-Ts had a high rate of durable responses with an excellent safety profile, highlighting the feasibility of extending CAR-T cell therapies beyond canonical B-cell malignancies.
Phase diagram of a frustrated asymmetric ferromagnetic spin ladder
Creators: name: Pan, Lihua
name: Zhang, Depeng
name: Hung, Hsiang-Hsuan
name: Liu, Yong-Jun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We perform a systematic investigation on the ground state of an asymmetric two-leg spin ladder (where exchange couplings of the legs are unequal) with ferromagnetic (FM) nearest-neighbor interaction and diagonal anti-ferromagnetic frustration using the Density Matrix Renormalization Group (DMRG) method. When the ladder is strongly asymmetric with moderate frustration, a magnetic canted state is observed between a FM state and a singlet dimerized state. The phase boundaries are dependent on the asymmetric strength $α_{a}$. On the other hand, when the asymmetric strength is intermediate, a so-called spin-stripe state (spins align parallel on same legs, but antiparallel on rungs) is discovered, and the system experiences a first-order phase transition from the FM state to the spin-stripe state upon increasing frustration. We present numerical evidence to interpret the phase diagram in terms of frustration and the asymmetric strength.
description: 14 pages, 8 figures
Interleukin-23 engineering improves CAR T cell function in solid tumors
Creators: name: Du, H.
name: Porterfield Kren, N.
name: Michaud, D.
name: Ma, X.
name: Pylayeva-Gupta, Y.
name: Savoldo, B.
name: Xu, Y.
name: Ahn, S.
name: Chen, Y.
name: Smith, C.
name: Sun, C.
name: Vincent, B.
name: Zhang, S.
name: Dotti, G.
name: Shou, P.
Publisher: name: Nature Research
Year: 2020

description: Cytokines that stimulate T cell proliferation, such as interleukin (IL)-15, have been explored as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells. However, constitutive cytokine signaling in T cells and activation of bystander cells may cause toxicity. IL-23 is a two-subunit cytokine known to promote proliferation of memory T cells and T helper type 17 cells. We found that, upon T cell antigen receptor (TCR) stimulation, T cells upregulated the IL-23 receptor and the IL-23α p19 subunit, but not the p40 subunit. We engineered expression of the p40 subunit in T cells (p40-Td cells) and obtained selective proliferative activity in activated T cells via autocrine IL-23 signaling. In comparison to CAR T cells, p40-Td CAR T cells showed improved antitumor capacity in vitro, with increased granzyme B and decreased PD-1 expression. In two xenograft and two syngeneic solid tumor mouse models, p40-Td CAR T cells showed superior efficacy in comparison to CAR T cells and attenuated side effects in comparison to CAR T cells expressing IL-18 or IL-15.
(4151) Frances Gertrude Chambers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Guidance for running online training
Creators: name: Sufi, Shoaib
name: Nenadic, Aleksandra
name: Ainsworth, Rachael
name: Michielin, Lucia
name: Crouch, Steve
name: Antonioletti, Mario
name: Peru, Giacomo
Publisher: name: Zenodo
Year: 2020
Subjects: online training
best practise
training
planning
zoom
live coding
software skills

description: The following is guidance based on the Software Sustainability Institute staff and collaborators running online training events which have become more needed due to the lockdown caused by the Covid-19 pandemic
(4149) John Upton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Traveling gravity water waves with critical layers
Creators: name: Aasen, Ailo
name: Varholm, Kristoffer
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35Q31 (Primary), 35B32, 35C07 (Secondary)

description: We establish the existence of small-amplitude uni- and bimodal steady periodic gravity waves with an affine vorticity distribution, using a bifurcation argument that differs slightly from earlier theory. The solutions describe waves with critical layers and an arbitrary number of crests and troughs in each minimal period. An important part of the analysis is a fairly complete description of the local geometry of the so-called kernel equation, and of the small-amplitude solutions. Finally, we investigate the asymptotic behavior of the bifurcating solutions.
description: 31 pages
First-principles calculation of the thermoelectric figure of merit for [2,2]paracyclophane-based single-molecule junctions
Creators: name: Bürkle, Marius
name: Hellmuth, Thomas J.
name: Pauly, Fabian
name: Asai, Yoshihiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Here we present a theoretical study of the thermoelectric transport through {[}2,2{]}para\-cyclo\-phane-based single-molecule junctions. Combining electronic and vibrational structures, obtained from density functional theory (DFT), with nonequilibrium Green's function techniques, allows us to treat both electronic and phononic transport properties at a first-principles level. For the electronic part, we include an approximate self-energy correction, based on the DFT+$Σ$ approach. This enables us to make a reliable prediction of all linear response transport coefficients entering the thermoelectric figure of merit $ZT$. Paracyclophane derivatives offer a great flexibility in tuning their chemical properties by attaching different functional groups. We show that, for the specific molecule, the functional groups mainly influence the thermopower, allowing to tune its sign and absolute value. We predict that the functionalization of the bare paracyclophane leads to a largely enhanced electronic contribution $Z_{\mathrm{el}}T$ to the figure of merit. Nevertheless, the high phononic contribution to the thermal conductance strongly suppresses $ZT$. Our work demonstrates the importance to include the phonon thermal conductance for any realistic estimate of the $ZT$ for off-resonant molecular transport junctions. In addition, it shows the possibility of a chemical tuning of the thermoelectric properties for a series of available molecules, leading to equally performing hole- and electron-conducting junctions based on the same molecular framework.
description: 8 pages, 7 figures