title: Analysis of 24h Mobil-O-Graph pulse wave analysis measurements in a normative population cohort
Creators: name: Weber, Johannes
Publisher: name: TU Wien
Year: 2016
Subjects: subject: Pulswellenanalyse
subject: Biosignalanalyse
subject: arterielle Steifigkeit
subject: arterieller Druck
subject: pulse wave analysis
subject: biosignal analysis
subject: arterial stiffness
subject: arterial pressure

description: Cardiovascular diseases (CVD) are the number one cause of death worldwide. Hemodynamics describes the fluid dynamics of the blood flow in the cardiovascular system (CVS). There are many different parameters coming from hemodynamics describing the health status of the CVS. In order to earlier and better detect CVDs a new approach is on its way to be established. The well-known ambulatory blood pressure monitoring (ABPM) is combined with pulse wave analysis (PWA). ABPM means recording blood pressure (BP) parameters at regular intervals with an automated device for example over 24 hours. PWA is used to determine the parameters near the heart termed as central or aortic parameters, in contrast to the common peripheral measurements at the upper or lower arm. The aim of this diploma thesis is to contribute to the task of establishing normal values for 24-hour measurements of central hemodynamic parameters, as well as showing an approach for the data evaluation and graphical representation. In Luebeck, Germany, a healthy population cohort consisting of 93 experimentees was recruited. They were advised to wear an automated ambulatory blood pressure monitor for 24 hours. The device used in this study was the Mobil-O-Graph from I.E.M. GmbH, Stolberg, Germany. The Mobil-O-Graph is the first device which combines PWA and ABPM. Thus, additionally to the common 24-hour assessment of peripheral blood pressure, central hemodynamic parameters can be evaluated over 24 hours as well. The data is classified by age, sex, and into day and night intervals. For the data evaluation the mean values of the groups are calculated and with statistical analysis the groups are analysed for differences. The graphical representation consists of 24-hour plots, where the data is smoothed before, and day/night scatter plots over age. The main findings of this thesis are the lower heart rate of men compared to women but the blood pressure parameters are higher of women than of men. The reflection magnitude, augmentation pressure, augmentation index, and augmentation index at 75 min--1 are higher for women than for men. The heart rate, peripheral and central systolic and diastolic BP values, and augmentation index at 75 min--1 are higher during day compared to the night. The reflection magnitude, augmentation pressure, and augmentation index are elevated during the night. A close positive correlation was found between age and pulse wave velocity. There is a strong negative correlation with age of the pulse pressure amplification for the day, but no correlation for the night interval. The reflection magnitude, augmentation pressure, and augmentation index have a high correlation coefficient during the day as well as for the night. The age groups differ most significantly for the pulse wave velocity. The pulse pressure amplification decreases over age, the reflection magnitude, augmentation pressure, augmentation index, and augmentation index at 75 min--1 increase with age. In this thesis one approach is shown for the data evaluation and graphical representation of 24-hour hemodynamic parameters. Nevertheless, still a lot of work has to be done to identify hemodynamic parameters as marker for cardiovascular diseases, as well as to establish characteristic values.